data_8PKN
# 
_entry.id   8PKN 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8PKN         pdb_00008pkn 10.2210/pdb8pkn/pdb 
WWPDB D_1292131384 ?            ?                   
EMDB  EMD-17748    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-01-15 ? 
2  'EM metadata'     1 0 2025-01-15 ? 
3  'Additional map'  1 0 2025-01-15 ? 
4  FSC               1 0 2025-01-15 ? 
5  'Half map'        1 0 2025-01-15 1 
6  'Half map'        1 0 2025-01-15 2 
7  Image             1 0 2025-01-15 ? 
8  Mask              1 0 2025-01-15 ? 
9  'Primary map'     1 0 2025-01-15 ? 
10 'Structure model' 1 1 2025-02-26 ? 
11 'EM metadata'     1 1 2025-02-26 ? 
12 'Structure model' 1 2 2025-03-05 ? 
13 'EM metadata'     1 2 2025-03-05 ? 
14 'Structure model' 1 3 2025-03-12 ? 
15 'EM metadata'     1 3 2025-03-12 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 Mask              repository 'Initial release' ? ? 
9 9 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1  10 'Structure model' 'Data collection'      
2  10 'Structure model' 'Database references'  
3  11 'EM metadata'     'Database references'  
4  11 'EM metadata'     'Experimental summary' 
5  12 'Structure model' 'Data collection'      
6  12 'Structure model' 'Database references'  
7  13 'EM metadata'     'Database references'  
8  13 'EM metadata'     'Experimental summary' 
9  14 'Structure model' 'Data collection'      
10 14 'Structure model' 'Database references'  
11 15 'EM metadata'     'Database references'  
12 15 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1  10 'Structure model' citation        
2  10 'Structure model' em_admin        
3  11 'EM metadata'     citation        
4  11 'EM metadata'     em_admin        
5  12 'Structure model' citation        
6  12 'Structure model' citation_author 
7  12 'Structure model' em_admin        
8  13 'EM metadata'     citation        
9  13 'EM metadata'     citation_author 
10 13 'EM metadata'     em_admin        
11 14 'Structure model' citation        
12 14 'Structure model' em_admin        
13 15 'EM metadata'     citation        
14 15 'EM metadata'     em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  10 'Structure model' '_citation.country'                 
2  10 'Structure model' '_citation.journal_abbrev'          
3  10 'Structure model' '_citation.journal_id_ASTM'         
4  10 'Structure model' '_citation.journal_id_CSD'          
5  10 'Structure model' '_citation.journal_id_ISSN'         
6  10 'Structure model' '_citation.pdbx_database_id_DOI'    
7  10 'Structure model' '_citation.title'                   
8  10 'Structure model' '_citation.year'                    
9  10 'Structure model' '_em_admin.last_update'             
10 11 'EM metadata'     '_citation.country'                 
11 11 'EM metadata'     '_citation.journal_abbrev'          
12 11 'EM metadata'     '_citation.journal_id_ASTM'         
13 11 'EM metadata'     '_citation.journal_id_CSD'          
14 11 'EM metadata'     '_citation.journal_id_ISSN'         
15 11 'EM metadata'     '_citation.pdbx_database_id_DOI'    
16 11 'EM metadata'     '_citation.title'                   
17 11 'EM metadata'     '_citation.year'                    
18 11 'EM metadata'     '_em_admin.last_update'             
19 12 'Structure model' '_citation.pdbx_database_id_PubMed' 
20 12 'Structure model' '_citation.title'                   
21 12 'Structure model' '_citation_author.identifier_ORCID' 
22 12 'Structure model' '_citation_author.name'             
23 12 'Structure model' '_em_admin.last_update'             
24 13 'EM metadata'     '_citation.pdbx_database_id_PubMed' 
25 13 'EM metadata'     '_citation.title'                   
26 13 'EM metadata'     '_citation_author.identifier_ORCID' 
27 13 'EM metadata'     '_citation_author.name'             
28 13 'EM metadata'     '_em_admin.last_update'             
29 14 'Structure model' '_citation.journal_volume'          
30 14 'Structure model' '_citation.page_first'              
31 14 'Structure model' '_citation.page_last'               
32 14 'Structure model' '_em_admin.last_update'             
33 15 'EM metadata'     '_citation.journal_volume'          
34 15 'EM metadata'     '_citation.page_first'              
35 15 'EM metadata'     '_citation.page_last'               
36 15 'EM metadata'     '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8PKN 
_pdbx_database_status.recvd_initial_deposition_date   2023-06-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                                                                 1hwk      unspecified 
EMDB 'CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin' EMD-17748 
'associated EM volume' 
PDB  'Apo enzyme'                                                                                      8S6B      unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jason.van-rooyen@diamond.ac.uk 
_pdbx_contact_author.name_first         Jason 
_pdbx_contact_author.name_last          'van Rooyen' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9485-8494 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Manikandan, K.' 1 0000-0001-5029-7816 
'Van Rooyen, J.' 2 0000-0001-9485-8494 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? US ? ? primary 'Acta Crystallogr.,Sect.F' ACSFEN ?    2053-230X ? ? 81  ? 118  122  
'Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.' 2025 ? 
10.1107/S2053230X25001098 39976191 ? ? 
? ? ? ? ? ? ? US ? ? 1       Science                    SCIEAS 0038 0036-8075 ? ? 292 ? 1160 1164 
'Structural mechanism for statin inhibition of HMG-CoA reductase.'                                        2001 ? 
10.1126/science.1059344   11349148 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Karuppasamy, M.' 1 ? 
primary 'van Rooyen, J.'  2 ? 
1       'Istvan, E.S.'    3 ? 
1       'Deisenhofer, J.' 4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3-hydroxy-3-methylglutaryl-coenzyme A reductase'                                                          
45259.016 1 1.1.1.34 ? ? ? 
2 non-polymer syn '7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID' 
558.640   1 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'HMG-CoA reductase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        
'7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID' 
_pdbx_entity_nonpoly.comp_id     117 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   ARG n 
1 3   GLU n 
1 4   PRO n 
1 5   ARG n 
1 6   PRO n 
1 7   ASN n 
1 8   GLU n 
1 9   GLU n 
1 10  CYS n 
1 11  LEU n 
1 12  GLN n 
1 13  ILE n 
1 14  LEU n 
1 15  GLY n 
1 16  ASN n 
1 17  ALA n 
1 18  GLU n 
1 19  LYS n 
1 20  GLY n 
1 21  ALA n 
1 22  LYS n 
1 23  PHE n 
1 24  LEU n 
1 25  SER n 
1 26  ASP n 
1 27  ALA n 
1 28  GLU n 
1 29  ILE n 
1 30  ILE n 
1 31  GLN n 
1 32  LEU n 
1 33  VAL n 
1 34  ASN n 
1 35  ALA n 
1 36  LYS n 
1 37  HIS n 
1 38  ILE n 
1 39  PRO n 
1 40  ALA n 
1 41  TYR n 
1 42  LYS n 
1 43  LEU n 
1 44  GLU n 
1 45  THR n 
1 46  LEU n 
1 47  MET n 
1 48  GLU n 
1 49  THR n 
1 50  HIS n 
1 51  GLU n 
1 52  ARG n 
1 53  GLY n 
1 54  VAL n 
1 55  SER n 
1 56  ILE n 
1 57  ARG n 
1 58  ARG n 
1 59  GLN n 
1 60  LEU n 
1 61  LEU n 
1 62  SER n 
1 63  LYS n 
1 64  LYS n 
1 65  LEU n 
1 66  SER n 
1 67  GLU n 
1 68  PRO n 
1 69  SER n 
1 70  SER n 
1 71  LEU n 
1 72  GLN n 
1 73  TYR n 
1 74  LEU n 
1 75  PRO n 
1 76  TYR n 
1 77  ARG n 
1 78  ASP n 
1 79  TYR n 
1 80  ASN n 
1 81  TYR n 
1 82  SER n 
1 83  LEU n 
1 84  VAL n 
1 85  MET n 
1 86  GLY n 
1 87  ALA n 
1 88  CYS n 
1 89  CYS n 
1 90  GLU n 
1 91  ASN n 
1 92  VAL n 
1 93  ILE n 
1 94  GLY n 
1 95  TYR n 
1 96  MET n 
1 97  PRO n 
1 98  ILE n 
1 99  PRO n 
1 100 VAL n 
1 101 GLY n 
1 102 VAL n 
1 103 ALA n 
1 104 GLY n 
1 105 PRO n 
1 106 LEU n 
1 107 CYS n 
1 108 LEU n 
1 109 ASP n 
1 110 GLU n 
1 111 LYS n 
1 112 GLU n 
1 113 PHE n 
1 114 GLN n 
1 115 VAL n 
1 116 PRO n 
1 117 MET n 
1 118 ALA n 
1 119 THR n 
1 120 THR n 
1 121 GLU n 
1 122 GLY n 
1 123 CYS n 
1 124 LEU n 
1 125 VAL n 
1 126 ALA n 
1 127 SER n 
1 128 THR n 
1 129 ASN n 
1 130 ARG n 
1 131 GLY n 
1 132 CYS n 
1 133 ARG n 
1 134 ALA n 
1 135 ILE n 
1 136 GLY n 
1 137 LEU n 
1 138 GLY n 
1 139 GLY n 
1 140 GLY n 
1 141 ALA n 
1 142 SER n 
1 143 SER n 
1 144 ARG n 
1 145 VAL n 
1 146 LEU n 
1 147 ALA n 
1 148 ASP n 
1 149 GLY n 
1 150 MET n 
1 151 THR n 
1 152 ARG n 
1 153 GLY n 
1 154 PRO n 
1 155 VAL n 
1 156 VAL n 
1 157 ARG n 
1 158 LEU n 
1 159 PRO n 
1 160 ARG n 
1 161 ALA n 
1 162 CYS n 
1 163 ASP n 
1 164 SER n 
1 165 ALA n 
1 166 GLU n 
1 167 VAL n 
1 168 LYS n 
1 169 ALA n 
1 170 TRP n 
1 171 LEU n 
1 172 GLU n 
1 173 THR n 
1 174 SER n 
1 175 GLU n 
1 176 GLY n 
1 177 PHE n 
1 178 ALA n 
1 179 VAL n 
1 180 ILE n 
1 181 LYS n 
1 182 GLU n 
1 183 ALA n 
1 184 PHE n 
1 185 ASP n 
1 186 SER n 
1 187 THR n 
1 188 SER n 
1 189 ARG n 
1 190 PHE n 
1 191 ALA n 
1 192 ARG n 
1 193 LEU n 
1 194 GLN n 
1 195 LYS n 
1 196 LEU n 
1 197 HIS n 
1 198 THR n 
1 199 SER n 
1 200 ILE n 
1 201 ALA n 
1 202 GLY n 
1 203 ARG n 
1 204 ASN n 
1 205 LEU n 
1 206 TYR n 
1 207 ILE n 
1 208 ARG n 
1 209 PHE n 
1 210 GLN n 
1 211 SER n 
1 212 ARG n 
1 213 SER n 
1 214 GLY n 
1 215 ASP n 
1 216 ALA n 
1 217 MET n 
1 218 GLY n 
1 219 MET n 
1 220 ASN n 
1 221 MET n 
1 222 ILE n 
1 223 SER n 
1 224 LYS n 
1 225 GLY n 
1 226 THR n 
1 227 GLU n 
1 228 LYS n 
1 229 ALA n 
1 230 LEU n 
1 231 SER n 
1 232 LYS n 
1 233 LEU n 
1 234 HIS n 
1 235 GLU n 
1 236 TYR n 
1 237 PHE n 
1 238 PRO n 
1 239 GLU n 
1 240 MET n 
1 241 GLN n 
1 242 ILE n 
1 243 LEU n 
1 244 ALA n 
1 245 VAL n 
1 246 SER n 
1 247 GLY n 
1 248 ASN n 
1 249 TYR n 
1 250 CYS n 
1 251 THR n 
1 252 ASP n 
1 253 LYS n 
1 254 LYS n 
1 255 PRO n 
1 256 ALA n 
1 257 ALA n 
1 258 ILE n 
1 259 ASN n 
1 260 TRP n 
1 261 ILE n 
1 262 GLU n 
1 263 GLY n 
1 264 ARG n 
1 265 GLY n 
1 266 LYS n 
1 267 SER n 
1 268 VAL n 
1 269 VAL n 
1 270 CYS n 
1 271 GLU n 
1 272 ALA n 
1 273 VAL n 
1 274 ILE n 
1 275 PRO n 
1 276 ALA n 
1 277 LYS n 
1 278 VAL n 
1 279 VAL n 
1 280 ARG n 
1 281 GLU n 
1 282 VAL n 
1 283 LEU n 
1 284 LYS n 
1 285 THR n 
1 286 THR n 
1 287 THR n 
1 288 GLU n 
1 289 ALA n 
1 290 MET n 
1 291 ILE n 
1 292 GLU n 
1 293 VAL n 
1 294 ASN n 
1 295 ILE n 
1 296 ASN n 
1 297 LYS n 
1 298 ASN n 
1 299 LEU n 
1 300 VAL n 
1 301 GLY n 
1 302 SER n 
1 303 ALA n 
1 304 MET n 
1 305 ALA n 
1 306 GLY n 
1 307 SER n 
1 308 ILE n 
1 309 GLY n 
1 310 GLY n 
1 311 TYR n 
1 312 ASN n 
1 313 ALA n 
1 314 HIS n 
1 315 ALA n 
1 316 ALA n 
1 317 ASN n 
1 318 ILE n 
1 319 VAL n 
1 320 THR n 
1 321 ALA n 
1 322 ILE n 
1 323 TYR n 
1 324 ILE n 
1 325 ALA n 
1 326 CYS n 
1 327 GLY n 
1 328 GLN n 
1 329 ASP n 
1 330 ALA n 
1 331 ALA n 
1 332 GLN n 
1 333 ASN n 
1 334 VAL n 
1 335 GLY n 
1 336 SER n 
1 337 SER n 
1 338 ASN n 
1 339 CYS n 
1 340 ILE n 
1 341 THR n 
1 342 LEU n 
1 343 MET n 
1 344 GLU n 
1 345 ALA n 
1 346 SER n 
1 347 GLY n 
1 348 PRO n 
1 349 THR n 
1 350 ASN n 
1 351 GLU n 
1 352 ASP n 
1 353 LEU n 
1 354 TYR n 
1 355 ILE n 
1 356 SER n 
1 357 CYS n 
1 358 THR n 
1 359 MET n 
1 360 PRO n 
1 361 SER n 
1 362 ILE n 
1 363 GLU n 
1 364 ILE n 
1 365 GLY n 
1 366 THR n 
1 367 VAL n 
1 368 GLY n 
1 369 GLY n 
1 370 GLY n 
1 371 THR n 
1 372 ASN n 
1 373 LEU n 
1 374 LEU n 
1 375 PRO n 
1 376 GLN n 
1 377 GLN n 
1 378 ALA n 
1 379 CYS n 
1 380 LEU n 
1 381 GLN n 
1 382 MET n 
1 383 LEU n 
1 384 GLY n 
1 385 VAL n 
1 386 GLN n 
1 387 GLY n 
1 388 ALA n 
1 389 CYS n 
1 390 LYS n 
1 391 ASP n 
1 392 ASN n 
1 393 PRO n 
1 394 GLY n 
1 395 GLU n 
1 396 ASN n 
1 397 ALA n 
1 398 ARG n 
1 399 GLN n 
1 400 LEU n 
1 401 ALA n 
1 402 ARG n 
1 403 ILE n 
1 404 VAL n 
1 405 CYS n 
1 406 GLY n 
1 407 THR n 
1 408 VAL n 
1 409 MET n 
1 410 ALA n 
1 411 GLY n 
1 412 GLU n 
1 413 LEU n 
1 414 SER n 
1 415 LEU n 
1 416 MET n 
1 417 ALA n 
1 418 ALA n 
1 419 LEU n 
1 420 ALA n 
1 421 ALA n 
1 422 GLY n 
1 423 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   423 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 HMGCR 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
117 non-polymer         . 
'7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID' ATORVASTATIN 
'C33 H35 F N2 O5' 558.640 
ALA 'L-peptide linking' y ALANINE ?            'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE ?            'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE ?            'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?            'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE ?            'C3 H7 N O2 S'    121.158 
GLN 'L-peptide linking' y GLUTAMINE ?            'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?            'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE ?            'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE ?            'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE ?            'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE ?            'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE ?            'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE ?            'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?            'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE ?            'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE ?            'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE ?            'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?            'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE ?            'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE ?            'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   439 439 PRO PRO A . n 
A 1 2   ARG 2   440 440 ARG ARG A . n 
A 1 3   GLU 3   441 441 GLU GLU A . n 
A 1 4   PRO 4   442 442 PRO PRO A . n 
A 1 5   ARG 5   443 443 ARG ARG A . n 
A 1 6   PRO 6   444 444 PRO PRO A . n 
A 1 7   ASN 7   445 445 ASN ASN A . n 
A 1 8   GLU 8   446 446 GLU GLU A . n 
A 1 9   GLU 9   447 447 GLU GLU A . n 
A 1 10  CYS 10  448 448 CYS CYS A . n 
A 1 11  LEU 11  449 449 LEU LEU A . n 
A 1 12  GLN 12  450 450 GLN GLN A . n 
A 1 13  ILE 13  451 451 ILE ILE A . n 
A 1 14  LEU 14  452 452 LEU LEU A . n 
A 1 15  GLY 15  453 453 GLY GLY A . n 
A 1 16  ASN 16  454 454 ASN ASN A . n 
A 1 17  ALA 17  455 455 ALA ALA A . n 
A 1 18  GLU 18  456 456 GLU GLU A . n 
A 1 19  LYS 19  457 457 LYS LYS A . n 
A 1 20  GLY 20  458 458 GLY GLY A . n 
A 1 21  ALA 21  459 459 ALA ALA A . n 
A 1 22  LYS 22  460 460 LYS LYS A . n 
A 1 23  PHE 23  461 461 PHE PHE A . n 
A 1 24  LEU 24  462 462 LEU LEU A . n 
A 1 25  SER 25  463 463 SER SER A . n 
A 1 26  ASP 26  464 464 ASP ASP A . n 
A 1 27  ALA 27  465 465 ALA ALA A . n 
A 1 28  GLU 28  466 466 GLU GLU A . n 
A 1 29  ILE 29  467 467 ILE ILE A . n 
A 1 30  ILE 30  468 468 ILE ILE A . n 
A 1 31  GLN 31  469 469 GLN GLN A . n 
A 1 32  LEU 32  470 470 LEU LEU A . n 
A 1 33  VAL 33  471 471 VAL VAL A . n 
A 1 34  ASN 34  472 472 ASN ASN A . n 
A 1 35  ALA 35  473 473 ALA ALA A . n 
A 1 36  LYS 36  474 474 LYS LYS A . n 
A 1 37  HIS 37  475 475 HIS HIS A . n 
A 1 38  ILE 38  476 476 ILE ILE A . n 
A 1 39  PRO 39  477 477 PRO PRO A . n 
A 1 40  ALA 40  478 478 ALA ALA A . n 
A 1 41  TYR 41  479 479 TYR TYR A . n 
A 1 42  LYS 42  480 480 LYS LYS A . n 
A 1 43  LEU 43  481 481 LEU LEU A . n 
A 1 44  GLU 44  482 482 GLU GLU A . n 
A 1 45  THR 45  483 483 THR THR A . n 
A 1 46  LEU 46  484 484 LEU LEU A . n 
A 1 47  MET 47  485 485 MET MET A . n 
A 1 48  GLU 48  486 486 GLU GLU A . n 
A 1 49  THR 49  487 487 THR THR A . n 
A 1 50  HIS 50  488 488 HIS HIS A . n 
A 1 51  GLU 51  489 489 GLU GLU A . n 
A 1 52  ARG 52  490 490 ARG ARG A . n 
A 1 53  GLY 53  491 491 GLY GLY A . n 
A 1 54  VAL 54  492 492 VAL VAL A . n 
A 1 55  SER 55  493 493 SER SER A . n 
A 1 56  ILE 56  494 494 ILE ILE A . n 
A 1 57  ARG 57  495 495 ARG ARG A . n 
A 1 58  ARG 58  496 496 ARG ARG A . n 
A 1 59  GLN 59  497 497 GLN GLN A . n 
A 1 60  LEU 60  498 498 LEU LEU A . n 
A 1 61  LEU 61  499 499 LEU LEU A . n 
A 1 62  SER 62  500 500 SER SER A . n 
A 1 63  LYS 63  501 501 LYS LYS A . n 
A 1 64  LYS 64  502 502 LYS LYS A . n 
A 1 65  LEU 65  503 503 LEU LEU A . n 
A 1 66  SER 66  504 504 SER SER A . n 
A 1 67  GLU 67  505 505 GLU GLU A . n 
A 1 68  PRO 68  506 506 PRO PRO A . n 
A 1 69  SER 69  507 507 SER SER A . n 
A 1 70  SER 70  508 508 SER SER A . n 
A 1 71  LEU 71  509 509 LEU LEU A . n 
A 1 72  GLN 72  510 510 GLN GLN A . n 
A 1 73  TYR 73  511 511 TYR TYR A . n 
A 1 74  LEU 74  512 512 LEU LEU A . n 
A 1 75  PRO 75  513 513 PRO PRO A . n 
A 1 76  TYR 76  514 514 TYR TYR A . n 
A 1 77  ARG 77  515 515 ARG ARG A . n 
A 1 78  ASP 78  516 516 ASP ASP A . n 
A 1 79  TYR 79  517 517 TYR TYR A . n 
A 1 80  ASN 80  518 518 ASN ASN A . n 
A 1 81  TYR 81  519 519 TYR TYR A . n 
A 1 82  SER 82  520 520 SER SER A . n 
A 1 83  LEU 83  521 521 LEU LEU A . n 
A 1 84  VAL 84  522 522 VAL VAL A . n 
A 1 85  MET 85  523 523 MET MET A . n 
A 1 86  GLY 86  524 524 GLY GLY A . n 
A 1 87  ALA 87  525 525 ALA ALA A . n 
A 1 88  CYS 88  526 526 CYS CYS A . n 
A 1 89  CYS 89  527 527 CYS CYS A . n 
A 1 90  GLU 90  528 528 GLU GLU A . n 
A 1 91  ASN 91  529 529 ASN ASN A . n 
A 1 92  VAL 92  530 530 VAL VAL A . n 
A 1 93  ILE 93  531 531 ILE ILE A . n 
A 1 94  GLY 94  532 532 GLY GLY A . n 
A 1 95  TYR 95  533 533 TYR TYR A . n 
A 1 96  MET 96  534 534 MET MET A . n 
A 1 97  PRO 97  535 535 PRO PRO A . n 
A 1 98  ILE 98  536 536 ILE ILE A . n 
A 1 99  PRO 99  537 537 PRO PRO A . n 
A 1 100 VAL 100 538 538 VAL VAL A . n 
A 1 101 GLY 101 539 539 GLY GLY A . n 
A 1 102 VAL 102 540 540 VAL VAL A . n 
A 1 103 ALA 103 541 541 ALA ALA A . n 
A 1 104 GLY 104 542 542 GLY GLY A . n 
A 1 105 PRO 105 543 543 PRO PRO A . n 
A 1 106 LEU 106 544 544 LEU LEU A . n 
A 1 107 CYS 107 545 545 CYS CYS A . n 
A 1 108 LEU 108 546 546 LEU LEU A . n 
A 1 109 ASP 109 547 547 ASP ASP A . n 
A 1 110 GLU 110 548 548 GLU GLU A . n 
A 1 111 LYS 111 549 549 LYS LYS A . n 
A 1 112 GLU 112 550 550 GLU GLU A . n 
A 1 113 PHE 113 551 551 PHE PHE A . n 
A 1 114 GLN 114 552 552 GLN GLN A . n 
A 1 115 VAL 115 553 553 VAL VAL A . n 
A 1 116 PRO 116 554 554 PRO PRO A . n 
A 1 117 MET 117 555 555 MET MET A . n 
A 1 118 ALA 118 556 556 ALA ALA A . n 
A 1 119 THR 119 557 557 THR THR A . n 
A 1 120 THR 120 558 558 THR THR A . n 
A 1 121 GLU 121 559 559 GLU GLU A . n 
A 1 122 GLY 122 560 560 GLY GLY A . n 
A 1 123 CYS 123 561 561 CYS CYS A . n 
A 1 124 LEU 124 562 562 LEU LEU A . n 
A 1 125 VAL 125 563 563 VAL VAL A . n 
A 1 126 ALA 126 564 564 ALA ALA A . n 
A 1 127 SER 127 565 565 SER SER A . n 
A 1 128 THR 128 566 566 THR THR A . n 
A 1 129 ASN 129 567 567 ASN ASN A . n 
A 1 130 ARG 130 568 568 ARG ARG A . n 
A 1 131 GLY 131 569 569 GLY GLY A . n 
A 1 132 CYS 132 570 570 CYS CYS A . n 
A 1 133 ARG 133 571 571 ARG ARG A . n 
A 1 134 ALA 134 572 572 ALA ALA A . n 
A 1 135 ILE 135 573 573 ILE ILE A . n 
A 1 136 GLY 136 574 574 GLY GLY A . n 
A 1 137 LEU 137 575 575 LEU LEU A . n 
A 1 138 GLY 138 576 576 GLY GLY A . n 
A 1 139 GLY 139 577 577 GLY GLY A . n 
A 1 140 GLY 140 578 578 GLY GLY A . n 
A 1 141 ALA 141 579 579 ALA ALA A . n 
A 1 142 SER 142 580 580 SER SER A . n 
A 1 143 SER 143 581 581 SER SER A . n 
A 1 144 ARG 144 582 582 ARG ARG A . n 
A 1 145 VAL 145 583 583 VAL VAL A . n 
A 1 146 LEU 146 584 584 LEU LEU A . n 
A 1 147 ALA 147 585 585 ALA ALA A . n 
A 1 148 ASP 148 586 586 ASP ASP A . n 
A 1 149 GLY 149 587 587 GLY GLY A . n 
A 1 150 MET 150 588 588 MET MET A . n 
A 1 151 THR 151 589 589 THR THR A . n 
A 1 152 ARG 152 590 590 ARG ARG A . n 
A 1 153 GLY 153 591 591 GLY GLY A . n 
A 1 154 PRO 154 592 592 PRO PRO A . n 
A 1 155 VAL 155 593 593 VAL VAL A . n 
A 1 156 VAL 156 594 594 VAL VAL A . n 
A 1 157 ARG 157 595 595 ARG ARG A . n 
A 1 158 LEU 158 596 596 LEU LEU A . n 
A 1 159 PRO 159 597 597 PRO PRO A . n 
A 1 160 ARG 160 598 598 ARG ARG A . n 
A 1 161 ALA 161 599 599 ALA ALA A . n 
A 1 162 CYS 162 600 600 CYS CYS A . n 
A 1 163 ASP 163 601 601 ASP ASP A . n 
A 1 164 SER 164 602 602 SER SER A . n 
A 1 165 ALA 165 603 603 ALA ALA A . n 
A 1 166 GLU 166 604 604 GLU GLU A . n 
A 1 167 VAL 167 605 605 VAL VAL A . n 
A 1 168 LYS 168 606 606 LYS LYS A . n 
A 1 169 ALA 169 607 607 ALA ALA A . n 
A 1 170 TRP 170 608 608 TRP TRP A . n 
A 1 171 LEU 171 609 609 LEU LEU A . n 
A 1 172 GLU 172 610 610 GLU GLU A . n 
A 1 173 THR 173 611 611 THR THR A . n 
A 1 174 SER 174 612 612 SER SER A . n 
A 1 175 GLU 175 613 613 GLU GLU A . n 
A 1 176 GLY 176 614 614 GLY GLY A . n 
A 1 177 PHE 177 615 615 PHE PHE A . n 
A 1 178 ALA 178 616 616 ALA ALA A . n 
A 1 179 VAL 179 617 617 VAL VAL A . n 
A 1 180 ILE 180 618 618 ILE ILE A . n 
A 1 181 LYS 181 619 619 LYS LYS A . n 
A 1 182 GLU 182 620 620 GLU GLU A . n 
A 1 183 ALA 183 621 621 ALA ALA A . n 
A 1 184 PHE 184 622 622 PHE PHE A . n 
A 1 185 ASP 185 623 623 ASP ASP A . n 
A 1 186 SER 186 624 624 SER SER A . n 
A 1 187 THR 187 625 625 THR THR A . n 
A 1 188 SER 188 626 626 SER SER A . n 
A 1 189 ARG 189 627 627 ARG ARG A . n 
A 1 190 PHE 190 628 628 PHE PHE A . n 
A 1 191 ALA 191 629 629 ALA ALA A . n 
A 1 192 ARG 192 630 630 ARG ARG A . n 
A 1 193 LEU 193 631 631 LEU LEU A . n 
A 1 194 GLN 194 632 632 GLN GLN A . n 
A 1 195 LYS 195 633 633 LYS LYS A . n 
A 1 196 LEU 196 634 634 LEU LEU A . n 
A 1 197 HIS 197 635 635 HIS HIS A . n 
A 1 198 THR 198 636 636 THR THR A . n 
A 1 199 SER 199 637 637 SER SER A . n 
A 1 200 ILE 200 638 638 ILE ILE A . n 
A 1 201 ALA 201 639 639 ALA ALA A . n 
A 1 202 GLY 202 640 640 GLY GLY A . n 
A 1 203 ARG 203 641 641 ARG ARG A . n 
A 1 204 ASN 204 642 642 ASN ASN A . n 
A 1 205 LEU 205 643 643 LEU LEU A . n 
A 1 206 TYR 206 644 644 TYR TYR A . n 
A 1 207 ILE 207 645 645 ILE ILE A . n 
A 1 208 ARG 208 646 646 ARG ARG A . n 
A 1 209 PHE 209 647 647 PHE PHE A . n 
A 1 210 GLN 210 648 648 GLN GLN A . n 
A 1 211 SER 211 649 649 SER SER A . n 
A 1 212 ARG 212 650 650 ARG ARG A . n 
A 1 213 SER 213 651 651 SER SER A . n 
A 1 214 GLY 214 652 652 GLY GLY A . n 
A 1 215 ASP 215 653 653 ASP ASP A . n 
A 1 216 ALA 216 654 654 ALA ALA A . n 
A 1 217 MET 217 655 655 MET MET A . n 
A 1 218 GLY 218 656 656 GLY GLY A . n 
A 1 219 MET 219 657 657 MET MET A . n 
A 1 220 ASN 220 658 658 ASN ASN A . n 
A 1 221 MET 221 659 659 MET MET A . n 
A 1 222 ILE 222 660 660 ILE ILE A . n 
A 1 223 SER 223 661 661 SER SER A . n 
A 1 224 LYS 224 662 662 LYS LYS A . n 
A 1 225 GLY 225 663 663 GLY GLY A . n 
A 1 226 THR 226 664 664 THR THR A . n 
A 1 227 GLU 227 665 665 GLU GLU A . n 
A 1 228 LYS 228 666 666 LYS LYS A . n 
A 1 229 ALA 229 667 667 ALA ALA A . n 
A 1 230 LEU 230 668 668 LEU LEU A . n 
A 1 231 SER 231 669 669 SER SER A . n 
A 1 232 LYS 232 670 670 LYS LYS A . n 
A 1 233 LEU 233 671 671 LEU LEU A . n 
A 1 234 HIS 234 672 672 HIS HIS A . n 
A 1 235 GLU 235 673 673 GLU GLU A . n 
A 1 236 TYR 236 674 674 TYR TYR A . n 
A 1 237 PHE 237 675 675 PHE PHE A . n 
A 1 238 PRO 238 676 676 PRO PRO A . n 
A 1 239 GLU 239 677 677 GLU GLU A . n 
A 1 240 MET 240 678 678 MET MET A . n 
A 1 241 GLN 241 679 679 GLN GLN A . n 
A 1 242 ILE 242 680 680 ILE ILE A . n 
A 1 243 LEU 243 681 681 LEU LEU A . n 
A 1 244 ALA 244 682 682 ALA ALA A . n 
A 1 245 VAL 245 683 683 VAL VAL A . n 
A 1 246 SER 246 684 684 SER SER A . n 
A 1 247 GLY 247 685 685 GLY GLY A . n 
A 1 248 ASN 248 686 686 ASN ASN A . n 
A 1 249 TYR 249 687 687 TYR TYR A . n 
A 1 250 CYS 250 688 688 CYS CYS A . n 
A 1 251 THR 251 689 689 THR THR A . n 
A 1 252 ASP 252 690 690 ASP ASP A . n 
A 1 253 LYS 253 691 691 LYS LYS A . n 
A 1 254 LYS 254 692 692 LYS LYS A . n 
A 1 255 PRO 255 693 693 PRO PRO A . n 
A 1 256 ALA 256 694 694 ALA ALA A . n 
A 1 257 ALA 257 695 695 ALA ALA A . n 
A 1 258 ILE 258 696 696 ILE ILE A . n 
A 1 259 ASN 259 697 697 ASN ASN A . n 
A 1 260 TRP 260 698 698 TRP TRP A . n 
A 1 261 ILE 261 699 699 ILE ILE A . n 
A 1 262 GLU 262 700 700 GLU GLU A . n 
A 1 263 GLY 263 701 701 GLY GLY A . n 
A 1 264 ARG 264 702 702 ARG ARG A . n 
A 1 265 GLY 265 703 703 GLY GLY A . n 
A 1 266 LYS 266 704 704 LYS LYS A . n 
A 1 267 SER 267 705 705 SER SER A . n 
A 1 268 VAL 268 706 706 VAL VAL A . n 
A 1 269 VAL 269 707 707 VAL VAL A . n 
A 1 270 CYS 270 708 708 CYS CYS A . n 
A 1 271 GLU 271 709 709 GLU GLU A . n 
A 1 272 ALA 272 710 710 ALA ALA A . n 
A 1 273 VAL 273 711 711 VAL VAL A . n 
A 1 274 ILE 274 712 712 ILE ILE A . n 
A 1 275 PRO 275 713 713 PRO PRO A . n 
A 1 276 ALA 276 714 714 ALA ALA A . n 
A 1 277 LYS 277 715 715 LYS LYS A . n 
A 1 278 VAL 278 716 716 VAL VAL A . n 
A 1 279 VAL 279 717 717 VAL VAL A . n 
A 1 280 ARG 280 718 718 ARG ARG A . n 
A 1 281 GLU 281 719 719 GLU GLU A . n 
A 1 282 VAL 282 720 720 VAL VAL A . n 
A 1 283 LEU 283 721 721 LEU LEU A . n 
A 1 284 LYS 284 722 722 LYS LYS A . n 
A 1 285 THR 285 723 723 THR THR A . n 
A 1 286 THR 286 724 724 THR THR A . n 
A 1 287 THR 287 725 725 THR THR A . n 
A 1 288 GLU 288 726 726 GLU GLU A . n 
A 1 289 ALA 289 727 727 ALA ALA A . n 
A 1 290 MET 290 728 728 MET MET A . n 
A 1 291 ILE 291 729 729 ILE ILE A . n 
A 1 292 GLU 292 730 730 GLU GLU A . n 
A 1 293 VAL 293 731 731 VAL VAL A . n 
A 1 294 ASN 294 732 732 ASN ASN A . n 
A 1 295 ILE 295 733 733 ILE ILE A . n 
A 1 296 ASN 296 734 734 ASN ASN A . n 
A 1 297 LYS 297 735 735 LYS LYS A . n 
A 1 298 ASN 298 736 736 ASN ASN A . n 
A 1 299 LEU 299 737 737 LEU LEU A . n 
A 1 300 VAL 300 738 738 VAL VAL A . n 
A 1 301 GLY 301 739 739 GLY GLY A . n 
A 1 302 SER 302 740 740 SER SER A . n 
A 1 303 ALA 303 741 741 ALA ALA A . n 
A 1 304 MET 304 742 742 MET MET A . n 
A 1 305 ALA 305 743 743 ALA ALA A . n 
A 1 306 GLY 306 744 744 GLY GLY A . n 
A 1 307 SER 307 745 745 SER SER A . n 
A 1 308 ILE 308 746 746 ILE ILE A . n 
A 1 309 GLY 309 747 747 GLY GLY A . n 
A 1 310 GLY 310 748 748 GLY GLY A . n 
A 1 311 TYR 311 749 749 TYR TYR A . n 
A 1 312 ASN 312 750 750 ASN ASN A . n 
A 1 313 ALA 313 751 751 ALA ALA A . n 
A 1 314 HIS 314 752 752 HIS HIS A . n 
A 1 315 ALA 315 753 753 ALA ALA A . n 
A 1 316 ALA 316 754 754 ALA ALA A . n 
A 1 317 ASN 317 755 755 ASN ASN A . n 
A 1 318 ILE 318 756 756 ILE ILE A . n 
A 1 319 VAL 319 757 757 VAL VAL A . n 
A 1 320 THR 320 758 758 THR THR A . n 
A 1 321 ALA 321 759 759 ALA ALA A . n 
A 1 322 ILE 322 760 760 ILE ILE A . n 
A 1 323 TYR 323 761 761 TYR TYR A . n 
A 1 324 ILE 324 762 762 ILE ILE A . n 
A 1 325 ALA 325 763 763 ALA ALA A . n 
A 1 326 CYS 326 764 764 CYS CYS A . n 
A 1 327 GLY 327 765 765 GLY GLY A . n 
A 1 328 GLN 328 766 766 GLN GLN A . n 
A 1 329 ASP 329 767 767 ASP ASP A . n 
A 1 330 ALA 330 768 768 ALA ALA A . n 
A 1 331 ALA 331 769 769 ALA ALA A . n 
A 1 332 GLN 332 770 770 GLN GLN A . n 
A 1 333 ASN 333 771 771 ASN ASN A . n 
A 1 334 VAL 334 772 772 VAL VAL A . n 
A 1 335 GLY 335 773 773 GLY GLY A . n 
A 1 336 SER 336 774 774 SER SER A . n 
A 1 337 SER 337 775 775 SER SER A . n 
A 1 338 ASN 338 776 776 ASN ASN A . n 
A 1 339 CYS 339 777 777 CYS CYS A . n 
A 1 340 ILE 340 778 778 ILE ILE A . n 
A 1 341 THR 341 779 779 THR THR A . n 
A 1 342 LEU 342 780 780 LEU LEU A . n 
A 1 343 MET 343 781 781 MET MET A . n 
A 1 344 GLU 344 782 782 GLU GLU A . n 
A 1 345 ALA 345 783 783 ALA ALA A . n 
A 1 346 SER 346 784 784 SER SER A . n 
A 1 347 GLY 347 785 785 GLY GLY A . n 
A 1 348 PRO 348 786 786 PRO PRO A . n 
A 1 349 THR 349 787 787 THR THR A . n 
A 1 350 ASN 350 788 788 ASN ASN A . n 
A 1 351 GLU 351 789 789 GLU GLU A . n 
A 1 352 ASP 352 790 790 ASP ASP A . n 
A 1 353 LEU 353 791 791 LEU LEU A . n 
A 1 354 TYR 354 792 792 TYR TYR A . n 
A 1 355 ILE 355 793 793 ILE ILE A . n 
A 1 356 SER 356 794 794 SER SER A . n 
A 1 357 CYS 357 795 795 CYS CYS A . n 
A 1 358 THR 358 796 796 THR THR A . n 
A 1 359 MET 359 797 797 MET MET A . n 
A 1 360 PRO 360 798 798 PRO PRO A . n 
A 1 361 SER 361 799 799 SER SER A . n 
A 1 362 ILE 362 800 800 ILE ILE A . n 
A 1 363 GLU 363 801 801 GLU GLU A . n 
A 1 364 ILE 364 802 802 ILE ILE A . n 
A 1 365 GLY 365 803 803 GLY GLY A . n 
A 1 366 THR 366 804 804 THR THR A . n 
A 1 367 VAL 367 805 805 VAL VAL A . n 
A 1 368 GLY 368 806 806 GLY GLY A . n 
A 1 369 GLY 369 807 807 GLY GLY A . n 
A 1 370 GLY 370 808 808 GLY GLY A . n 
A 1 371 THR 371 809 809 THR THR A . n 
A 1 372 ASN 372 810 810 ASN ASN A . n 
A 1 373 LEU 373 811 811 LEU LEU A . n 
A 1 374 LEU 374 812 812 LEU LEU A . n 
A 1 375 PRO 375 813 813 PRO PRO A . n 
A 1 376 GLN 376 814 814 GLN GLN A . n 
A 1 377 GLN 377 815 815 GLN GLN A . n 
A 1 378 ALA 378 816 816 ALA ALA A . n 
A 1 379 CYS 379 817 817 CYS CYS A . n 
A 1 380 LEU 380 818 818 LEU LEU A . n 
A 1 381 GLN 381 819 819 GLN GLN A . n 
A 1 382 MET 382 820 820 MET MET A . n 
A 1 383 LEU 383 821 821 LEU LEU A . n 
A 1 384 GLY 384 822 822 GLY GLY A . n 
A 1 385 VAL 385 823 823 VAL VAL A . n 
A 1 386 GLN 386 824 824 GLN GLN A . n 
A 1 387 GLY 387 825 825 GLY GLY A . n 
A 1 388 ALA 388 826 826 ALA ALA A . n 
A 1 389 CYS 389 827 827 CYS CYS A . n 
A 1 390 LYS 390 828 828 LYS LYS A . n 
A 1 391 ASP 391 829 829 ASP ASP A . n 
A 1 392 ASN 392 830 830 ASN ASN A . n 
A 1 393 PRO 393 831 831 PRO PRO A . n 
A 1 394 GLY 394 832 832 GLY GLY A . n 
A 1 395 GLU 395 833 833 GLU GLU A . n 
A 1 396 ASN 396 834 834 ASN ASN A . n 
A 1 397 ALA 397 835 835 ALA ALA A . n 
A 1 398 ARG 398 836 836 ARG ARG A . n 
A 1 399 GLN 399 837 837 GLN GLN A . n 
A 1 400 LEU 400 838 838 LEU LEU A . n 
A 1 401 ALA 401 839 839 ALA ALA A . n 
A 1 402 ARG 402 840 840 ARG ARG A . n 
A 1 403 ILE 403 841 841 ILE ILE A . n 
A 1 404 VAL 404 842 842 VAL VAL A . n 
A 1 405 CYS 405 843 843 CYS CYS A . n 
A 1 406 GLY 406 844 844 GLY GLY A . n 
A 1 407 THR 407 845 845 THR THR A . n 
A 1 408 VAL 408 846 846 VAL VAL A . n 
A 1 409 MET 409 847 847 MET MET A . n 
A 1 410 ALA 410 848 848 ALA ALA A . n 
A 1 411 GLY 411 849 849 GLY GLY A . n 
A 1 412 GLU 412 850 850 GLU GLU A . n 
A 1 413 LEU 413 851 851 LEU LEU A . n 
A 1 414 SER 414 852 852 SER SER A . n 
A 1 415 LEU 415 853 853 LEU LEU A . n 
A 1 416 MET 416 854 854 MET MET A . n 
A 1 417 ALA 417 855 855 ALA ALA A . n 
A 1 418 ALA 418 856 856 ALA ALA A . n 
A 1 419 LEU 419 857 857 LEU LEU A . n 
A 1 420 ALA 420 858 858 ALA ALA A . n 
A 1 421 ALA 421 859 859 ALA ALA A . n 
A 1 422 GLY 422 860 860 GLY GLY A . n 
A 1 423 HIS 423 861 861 HIS HIS A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        117 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   117 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          117 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     901 
_pdbx_nonpoly_scheme.auth_seq_num    901 
_pdbx_nonpoly_scheme.pdb_mon_id      117 
_pdbx_nonpoly_scheme.auth_mon_id     117 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8PKN 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8PKN 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8PKN 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               81.224 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.932 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8PKN 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.260 
_refine.ls_d_res_low                             147.740 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  252368 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.000 
_refine.ls_percent_reflns_R_free                 0.000 
_refine.ls_R_factor_all                          0.316 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.3158 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      0.316 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    NONE 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.082 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             3.345 
_refine.overall_SU_ML                            0.079 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 0.8673 
_refine.pdbx_average_fsc_work                    0.8673 
_refine.pdbx_average_fsc_free                    0.0000 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.007  0.012  3242  ? r_bond_refined_d               ? ? 
'ELECTRON MICROSCOPY' ? 0.000  0.016  3137  ? r_bond_other_d                 ? ? 
'ELECTRON MICROSCOPY' ? 1.305  1.816  4383  ? r_angle_refined_deg            ? ? 
'ELECTRON MICROSCOPY' ? 0.431  1.738  7229  ? r_angle_other_deg              ? ? 
'ELECTRON MICROSCOPY' ? 5.496  5.000  422   ? r_dihedral_angle_1_deg         ? ? 
'ELECTRON MICROSCOPY' ? 26.816 5.000  26    ? r_dihedral_angle_2_deg         ? ? 
'ELECTRON MICROSCOPY' ? 17.151 10.000 561   ? r_dihedral_angle_3_deg         ? ? 
'ELECTRON MICROSCOPY' ? 15.632 10.000 125   ? r_dihedral_angle_6_deg         ? ? 
'ELECTRON MICROSCOPY' ? 0.063  0.200  499   ? r_chiral_restr                 ? ? 
'ELECTRON MICROSCOPY' ? 0.006  0.020  3839  ? r_gen_planes_refined           ? ? 
'ELECTRON MICROSCOPY' ? 0.001  0.020  703   ? r_gen_planes_other             ? ? 
'ELECTRON MICROSCOPY' ? 0.233  0.200  712   ? r_nbd_refined                  ? ? 
'ELECTRON MICROSCOPY' ? 0.205  0.200  2906  ? r_symmetry_nbd_other           ? ? 
'ELECTRON MICROSCOPY' ? 0.184  0.200  1673  ? r_nbtor_refined                ? ? 
'ELECTRON MICROSCOPY' ? 0.079  0.200  1872  ? r_symmetry_nbtor_other         ? ? 
'ELECTRON MICROSCOPY' ? 0.204  0.200  47    ? r_xyhbond_nbd_refined          ? ? 
'ELECTRON MICROSCOPY' ? 0.035  0.200  1     ? r_symmetry_xyhbond_nbd_other   ? ? 
'ELECTRON MICROSCOPY' ? 0.196  0.200  26    ? r_symmetry_nbd_refined         ? ? 
'ELECTRON MICROSCOPY' ? 0.155  0.200  170   ? r_nbd_other                    ? ? 
'ELECTRON MICROSCOPY' ? 0.165  0.200  16    ? r_symmetry_xyhbond_nbd_refined ? ? 
'ELECTRON MICROSCOPY' ? 5.902  7.693  1691  ? r_mcbond_it                    ? ? 
'ELECTRON MICROSCOPY' ? 5.894  7.692  1691  ? r_mcbond_other                 ? ? 
'ELECTRON MICROSCOPY' ? 7.444  13.844 2112  ? r_mcangle_it                   ? ? 
'ELECTRON MICROSCOPY' ? 7.447  13.848 2113  ? r_mcangle_other                ? ? 
'ELECTRON MICROSCOPY' ? 7.895  8.617  1551  ? r_scbond_it                    ? ? 
'ELECTRON MICROSCOPY' ? 7.892  8.616  1552  ? r_scbond_other                 ? ? 
'ELECTRON MICROSCOPY' ? 10.940 15.438 2271  ? r_scangle_it                   ? ? 
'ELECTRON MICROSCOPY' ? 10.937 15.436 2272  ? r_scangle_other                ? ? 
'ELECTRON MICROSCOPY' ? 12.382 94.523 13515 ? r_lrange_it                    ? ? 
'ELECTRON MICROSCOPY' ? 12.382 94.520 13516 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'ELECTRON MICROSCOPY' 2.260  2.319   18744 . 0 18744 100.0000 . 2.543 . . 2.543 . . . . . 2.543 . 20 . 0.529 . . 
'ELECTRON MICROSCOPY' 2.319  2.382   18227 . 0 18227 100.0000 . 1.719 . . 1.719 . . . . . 1.719 . 20 . 0.701 . . 
'ELECTRON MICROSCOPY' 2.382  2.451   17711 . 0 17711 100.0000 . 1.489 . . 1.489 . . . . . 1.489 . 20 . 0.776 . . 
'ELECTRON MICROSCOPY' 2.451  2.527   17162 . 0 17162 100.0000 . 1.278 . . 1.278 . . . . . 1.278 . 20 . 0.830 . . 
'ELECTRON MICROSCOPY' 2.527  2.610   16619 . 0 16619 100.0000 . 1.057 . . 1.057 . . . . . 1.057 . 20 . 0.876 . . 
'ELECTRON MICROSCOPY' 2.610  2.701   16048 . 0 16048 100.0000 . 0.870 . . 0.870 . . . . . 0.870 . 20 . 0.904 . . 
'ELECTRON MICROSCOPY' 2.701  2.803   15642 . 0 15642 100.0000 . 0.638 . . 0.638 . . . . . 0.638 . 20 . 0.928 . . 
'ELECTRON MICROSCOPY' 2.803  2.917   14924 . 0 14924 100.0000 . 0.491 . . 0.491 . . . . . 0.491 . 20 . 0.939 . . 
'ELECTRON MICROSCOPY' 2.917  3.047   14332 . 0 14332 100.0000 . 0.343 . . 0.343 . . . . . 0.343 . 20 . 0.942 . . 
'ELECTRON MICROSCOPY' 3.047  3.196   13751 . 0 13751 100.0000 . 0.260 . . 0.260 . . . . . 0.260 . 20 . 0.949 . . 
'ELECTRON MICROSCOPY' 3.196  3.369   13028 . 0 13028 100.0000 . 0.215 . . 0.215 . . . . . 0.215 . 20 . 0.954 . . 
'ELECTRON MICROSCOPY' 3.369  3.573   12313 . 0 12313 100.0000 . 0.204 . . 0.204 . . . . . 0.204 . 20 . 0.955 . . 
'ELECTRON MICROSCOPY' 3.573  3.819   11587 . 0 11587 100.0000 . 0.229 . . 0.229 . . . . . 0.229 . 20 . 0.956 . . 
'ELECTRON MICROSCOPY' 3.819  4.125   10771 . 0 10771 100.0000 . 0.235 . . 0.235 . . . . . 0.235 . 20 . 0.955 . . 
'ELECTRON MICROSCOPY' 4.125  4.518   9899  . 0 9899  100.0000 . 0.251 . . 0.251 . . . . . 0.251 . 20 . 0.953 . . 
'ELECTRON MICROSCOPY' 4.518  5.051   9021  . 0 9021  100.0000 . 0.252 . . 0.252 . . . . . 0.252 . 20 . 0.942 . . 
'ELECTRON MICROSCOPY' 5.051  5.831   7896  . 0 7896  100.0000 . 0.271 . . 0.271 . . . . . 0.271 . 20 . 0.915 . . 
'ELECTRON MICROSCOPY' 5.831  7.139   6704  . 0 6704  100.0000 . 0.302 . . 0.302 . . . . . 0.302 . 20 . 0.890 . . 
'ELECTRON MICROSCOPY' 7.139  10.085  5156  . 0 5156  100.0000 . 0.286 . . 0.286 . . . . . 0.286 . 20 . 0.905 . . 
'ELECTRON MICROSCOPY' 10.085 147.740 2834  . 0 2834  100.0000 . 0.390 . . 0.390 . . . . . 0.390 . 20 . 0.960 . . 
# 
loop_
_struct_ncs_oper.id 
_struct_ncs_oper.code 
_struct_ncs_oper.matrix[1][1] 
_struct_ncs_oper.matrix[1][2] 
_struct_ncs_oper.matrix[1][3] 
_struct_ncs_oper.vector[1] 
_struct_ncs_oper.matrix[2][1] 
_struct_ncs_oper.matrix[2][2] 
_struct_ncs_oper.matrix[2][3] 
_struct_ncs_oper.vector[2] 
_struct_ncs_oper.matrix[3][1] 
_struct_ncs_oper.matrix[3][2] 
_struct_ncs_oper.matrix[3][3] 
_struct_ncs_oper.vector[3] 
_struct_ncs_oper.details 
1 given    1  0 0 0     0 1  0 0     0 0 1  0     ? 
2 generate -1 0 0 199.2 0 -1 0 199.2 0 0 1  0     ? 
3 generate 1  0 0 0     0 -1 0 199.2 0 0 -1 199.2 ? 
4 generate -1 0 0 199.2 0 1  0 0     0 0 -1 199.2 ? 
# 
_struct.entry_id                     8PKN 
_struct.title                        
'CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8PKN 
_struct_keywords.text            'reductase, cholesterol biosynthesis, lipitor, atorvastatin, statins, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HMDH_HUMAN 
_struct_ref.pdbx_db_accession          P04035 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;PREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYN
YSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPR
ACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEM
QILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVT
AIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQL
ARIVCGTVMAGELSLMAALAAGH
;
_struct_ref.pdbx_align_begin           439 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8PKN 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 423 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P04035 
_struct_ref_seq.db_align_beg                  439 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  861 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       439 
_struct_ref_seq.pdbx_auth_seq_align_end       861 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3,4 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z 1.0  0.0 0.0 0.0   0.0 1.0  0.0 0.0   0.0 0.0 1.0  0.0   
2 'point symmetry operation' ?     ?     -1.0 0.0 0.0 199.2 0.0 -1.0 0.0 199.2 0.0 0.0 1.0  0.0   
3 'point symmetry operation' ?     ?     1.0  0.0 0.0 0.0   0.0 -1.0 0.0 199.2 0.0 0.0 -1.0 199.2 
4 'point symmetry operation' ?     ?     -1.0 0.0 0.0 199.2 0.0 1.0  0.0 0.0   0.0 0.0 -1.0 199.2 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 CYS A 10  ? ASN A 16  ? CYS A 448 ASN A 454 1 ? 7  
HELX_P HELX_P2  AA2 SER A 25  ? ALA A 35  ? SER A 463 ALA A 473 1 ? 11 
HELX_P HELX_P3  AA3 PRO A 39  ? LEU A 43  ? PRO A 477 LEU A 481 5 ? 5  
HELX_P HELX_P4  AA4 THR A 49  ? LYS A 64  ? THR A 487 LYS A 502 1 ? 16 
HELX_P HELX_P5  AA5 SER A 69  ? LEU A 74  ? SER A 507 LEU A 512 5 ? 6  
HELX_P HELX_P6  AA6 CYS A 123 ? GLY A 138 ? CYS A 561 GLY A 576 1 ? 16 
HELX_P HELX_P7  AA7 ARG A 160 ? THR A 173 ? ARG A 598 THR A 611 1 ? 14 
HELX_P HELX_P8  AA8 THR A 173 ? SER A 186 ? THR A 611 SER A 624 1 ? 14 
HELX_P HELX_P9  AA9 GLY A 218 ? PHE A 237 ? GLY A 656 PHE A 675 1 ? 20 
HELX_P HELX_P10 AB1 ALA A 256 ? GLY A 263 ? ALA A 694 GLY A 701 1 ? 8  
HELX_P HELX_P11 AB2 PRO A 275 ? VAL A 282 ? PRO A 713 VAL A 720 1 ? 8  
HELX_P HELX_P12 AB3 THR A 286 ? LEU A 299 ? THR A 724 LEU A 737 1 ? 14 
HELX_P HELX_P13 AB4 LEU A 299 ? ALA A 305 ? LEU A 737 ALA A 743 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 314 ? CYS A 326 ? HIS A 752 CYS A 764 1 ? 13 
HELX_P HELX_P15 AB6 ASP A 329 ? ALA A 331 ? ASP A 767 ALA A 769 5 ? 3  
HELX_P HELX_P16 AB7 GLN A 332 ? SER A 337 ? GLN A 770 SER A 775 1 ? 6  
HELX_P HELX_P17 AB8 GLY A 368 ? ASN A 372 ? GLY A 806 ASN A 810 5 ? 5  
HELX_P HELX_P18 AB9 LEU A 373 ? LEU A 383 ? LEU A 811 LEU A 821 1 ? 11 
HELX_P HELX_P19 AC1 GLY A 394 ? GLY A 422 ? GLY A 832 GLY A 860 1 ? 29 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 104 A . ? GLY 542 A PRO 105 A ? PRO 543 A 1 1.68  
2 CYS 250 A . ? CYS 688 A THR 251 A ? THR 689 A 1 -2.34 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 4 ? 
AA3 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 100 ? LEU A 108 ? VAL A 538 LEU A 546 
AA1 2 LYS A 111 ? ALA A 118 ? LYS A 549 ALA A 556 
AA2 1 ARG A 192 ? LEU A 193 ? ARG A 630 LEU A 631 
AA2 2 ASN A 204 ? ARG A 212 ? ASN A 642 ARG A 650 
AA2 3 VAL A 155 ? ARG A 157 ? VAL A 593 ARG A 595 
AA2 4 GLN A 241 ? ALA A 244 ? GLN A 679 ALA A 682 
AA3 1 HIS A 197 ? ALA A 201 ? HIS A 635 ALA A 639 
AA3 2 ASN A 204 ? ARG A 212 ? ASN A 642 ARG A 650 
AA3 3 SER A 142 ? ARG A 152 ? SER A 580 ARG A 590 
AA3 4 GLY A 265 ? ILE A 274 ? GLY A 703 ILE A 712 
AA3 5 ASP A 352 ? ILE A 362 ? ASP A 790 ILE A 800 
AA3 6 CYS A 339 ? SER A 346 ? CYS A 777 SER A 784 
AA3 7 GLY A 310 ? TYR A 311 ? GLY A 748 TYR A 749 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 101 ? N GLY A 539 O MET A 117 ? O MET A 555 
AA2 1 2 O ARG A 192 ? O ARG A 630 N ARG A 212 ? N ARG A 650 
AA2 2 3 O LEU A 205 ? O LEU A 643 N VAL A 156 ? N VAL A 594 
AA2 3 4 N ARG A 157 ? N ARG A 595 O GLN A 241 ? O GLN A 679 
AA3 1 2 N SER A 199 ? N SER A 637 O TYR A 206 ? O TYR A 644 
AA3 2 3 O PHE A 209 ? O PHE A 647 N ARG A 152 ? N ARG A 590 
AA3 3 4 N LEU A 146 ? N LEU A 584 O SER A 267 ? O SER A 705 
AA3 4 5 N LYS A 266 ? N LYS A 704 O ILE A 362 ? O ILE A 800 
AA3 5 6 O SER A 356 ? O SER A 794 N LEU A 342 ? N LEU A 780 
AA3 6 7 O THR A 341 ? O THR A 779 N TYR A 311 ? N TYR A 749 
# 
_pdbx_entry_details.entry_id                   8PKN 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 444 ? ? -47.39  163.13 
2 1 CYS A 448 ? ? 75.71   -16.94 
3 1 LYS A 460 ? ? 81.96   -9.49  
4 1 ALA A 525 ? ? -133.93 -44.54 
5 1 CYS A 561 ? ? 84.41   -7.92  
6 1 SER A 651 ? ? -143.19 34.33  
7 1 LEU A 737 ? ? -96.64  -63.67 
8 1 TYR A 749 ? ? -95.38  57.02  
9 1 HIS A 752 ? ? -151.79 43.47  
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     595 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.223 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8PKN 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1hwk 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1hwk 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    8PKN 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.26 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               404712 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Catalytic part of hHMGCoA reductase' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8PKN 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           105000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8PKN 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8PKN 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8PKN 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        D2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
117 C17  C Y N 1   
117 C12  C Y N 2   
117 C13  C Y N 3   
117 C14  C Y N 4   
117 C15  C Y N 5   
117 C16  C Y N 6   
117 C83  C Y N 7   
117 C82  C Y N 8   
117 C81  C Y N 9   
117 C86  C Y N 10  
117 C85  C Y N 11  
117 C84  C Y N 12  
117 F1   F N N 13  
117 C8   C Y N 14  
117 C19  C Y N 15  
117 C20  C Y N 16  
117 C21  C Y N 17  
117 C22  C Y N 18  
117 C23  C Y N 19  
117 C24  C Y N 20  
117 O1B  O N N 21  
117 O1A  O N N 22  
117 O3   O N N 23  
117 C1   C N N 24  
117 C2   C N N 25  
117 C3   C N R 26  
117 C4   C N N 27  
117 C5   C N R 28  
117 C6   C N N 29  
117 C7   C N N 30  
117 N1   N Y N 31  
117 C10  C Y N 32  
117 C11  C Y N 33  
117 C18  C N N 34  
117 N2   N N N 35  
117 O18  O N N 36  
117 C9   C Y N 37  
117 C91  C N N 38  
117 C93  C N N 39  
117 C92  C N N 40  
117 O5   O N N 41  
117 H17  H N N 42  
117 H13  H N N 43  
117 H14  H N N 44  
117 H15  H N N 45  
117 H16  H N N 46  
117 H83  H N N 47  
117 H82  H N N 48  
117 H86  H N N 49  
117 H85  H N N 50  
117 H20  H N N 51  
117 H21  H N N 52  
117 H22  H N N 53  
117 H23  H N N 54  
117 H24  H N N 55  
117 H1B  H N N 56  
117 HO3  H N N 57  
117 H21A H N N 58  
117 H22A H N N 59  
117 H3   H N N 60  
117 H41  H N N 61  
117 H42  H N N 62  
117 H5   H N N 63  
117 H61  H N N 64  
117 H62  H N N 65  
117 H71  H N N 66  
117 H72  H N N 67  
117 HN2  H N N 68  
117 H91  H N N 69  
117 H931 H N N 70  
117 H932 H N N 71  
117 H933 H N N 72  
117 H921 H N N 73  
117 H922 H N N 74  
117 H923 H N N 75  
117 HO5  H N N 76  
ALA N    N N N 77  
ALA CA   C N S 78  
ALA C    C N N 79  
ALA O    O N N 80  
ALA CB   C N N 81  
ALA OXT  O N N 82  
ALA H    H N N 83  
ALA H2   H N N 84  
ALA HA   H N N 85  
ALA HB1  H N N 86  
ALA HB2  H N N 87  
ALA HB3  H N N 88  
ALA HXT  H N N 89  
ARG N    N N N 90  
ARG CA   C N S 91  
ARG C    C N N 92  
ARG O    O N N 93  
ARG CB   C N N 94  
ARG CG   C N N 95  
ARG CD   C N N 96  
ARG NE   N N N 97  
ARG CZ   C N N 98  
ARG NH1  N N N 99  
ARG NH2  N N N 100 
ARG OXT  O N N 101 
ARG H    H N N 102 
ARG H2   H N N 103 
ARG HA   H N N 104 
ARG HB2  H N N 105 
ARG HB3  H N N 106 
ARG HG2  H N N 107 
ARG HG3  H N N 108 
ARG HD2  H N N 109 
ARG HD3  H N N 110 
ARG HE   H N N 111 
ARG HH11 H N N 112 
ARG HH12 H N N 113 
ARG HH21 H N N 114 
ARG HH22 H N N 115 
ARG HXT  H N N 116 
ASN N    N N N 117 
ASN CA   C N S 118 
ASN C    C N N 119 
ASN O    O N N 120 
ASN CB   C N N 121 
ASN CG   C N N 122 
ASN OD1  O N N 123 
ASN ND2  N N N 124 
ASN OXT  O N N 125 
ASN H    H N N 126 
ASN H2   H N N 127 
ASN HA   H N N 128 
ASN HB2  H N N 129 
ASN HB3  H N N 130 
ASN HD21 H N N 131 
ASN HD22 H N N 132 
ASN HXT  H N N 133 
ASP N    N N N 134 
ASP CA   C N S 135 
ASP C    C N N 136 
ASP O    O N N 137 
ASP CB   C N N 138 
ASP CG   C N N 139 
ASP OD1  O N N 140 
ASP OD2  O N N 141 
ASP OXT  O N N 142 
ASP H    H N N 143 
ASP H2   H N N 144 
ASP HA   H N N 145 
ASP HB2  H N N 146 
ASP HB3  H N N 147 
ASP HD2  H N N 148 
ASP HXT  H N N 149 
CYS N    N N N 150 
CYS CA   C N R 151 
CYS C    C N N 152 
CYS O    O N N 153 
CYS CB   C N N 154 
CYS SG   S N N 155 
CYS OXT  O N N 156 
CYS H    H N N 157 
CYS H2   H N N 158 
CYS HA   H N N 159 
CYS HB2  H N N 160 
CYS HB3  H N N 161 
CYS HG   H N N 162 
CYS HXT  H N N 163 
GLN N    N N N 164 
GLN CA   C N S 165 
GLN C    C N N 166 
GLN O    O N N 167 
GLN CB   C N N 168 
GLN CG   C N N 169 
GLN CD   C N N 170 
GLN OE1  O N N 171 
GLN NE2  N N N 172 
GLN OXT  O N N 173 
GLN H    H N N 174 
GLN H2   H N N 175 
GLN HA   H N N 176 
GLN HB2  H N N 177 
GLN HB3  H N N 178 
GLN HG2  H N N 179 
GLN HG3  H N N 180 
GLN HE21 H N N 181 
GLN HE22 H N N 182 
GLN HXT  H N N 183 
GLU N    N N N 184 
GLU CA   C N S 185 
GLU C    C N N 186 
GLU O    O N N 187 
GLU CB   C N N 188 
GLU CG   C N N 189 
GLU CD   C N N 190 
GLU OE1  O N N 191 
GLU OE2  O N N 192 
GLU OXT  O N N 193 
GLU H    H N N 194 
GLU H2   H N N 195 
GLU HA   H N N 196 
GLU HB2  H N N 197 
GLU HB3  H N N 198 
GLU HG2  H N N 199 
GLU HG3  H N N 200 
GLU HE2  H N N 201 
GLU HXT  H N N 202 
GLY N    N N N 203 
GLY CA   C N N 204 
GLY C    C N N 205 
GLY O    O N N 206 
GLY OXT  O N N 207 
GLY H    H N N 208 
GLY H2   H N N 209 
GLY HA2  H N N 210 
GLY HA3  H N N 211 
GLY HXT  H N N 212 
HIS N    N N N 213 
HIS CA   C N S 214 
HIS C    C N N 215 
HIS O    O N N 216 
HIS CB   C N N 217 
HIS CG   C Y N 218 
HIS ND1  N Y N 219 
HIS CD2  C Y N 220 
HIS CE1  C Y N 221 
HIS NE2  N Y N 222 
HIS OXT  O N N 223 
HIS H    H N N 224 
HIS H2   H N N 225 
HIS HA   H N N 226 
HIS HB2  H N N 227 
HIS HB3  H N N 228 
HIS HD1  H N N 229 
HIS HD2  H N N 230 
HIS HE1  H N N 231 
HIS HE2  H N N 232 
HIS HXT  H N N 233 
ILE N    N N N 234 
ILE CA   C N S 235 
ILE C    C N N 236 
ILE O    O N N 237 
ILE CB   C N S 238 
ILE CG1  C N N 239 
ILE CG2  C N N 240 
ILE CD1  C N N 241 
ILE OXT  O N N 242 
ILE H    H N N 243 
ILE H2   H N N 244 
ILE HA   H N N 245 
ILE HB   H N N 246 
ILE HG12 H N N 247 
ILE HG13 H N N 248 
ILE HG21 H N N 249 
ILE HG22 H N N 250 
ILE HG23 H N N 251 
ILE HD11 H N N 252 
ILE HD12 H N N 253 
ILE HD13 H N N 254 
ILE HXT  H N N 255 
LEU N    N N N 256 
LEU CA   C N S 257 
LEU C    C N N 258 
LEU O    O N N 259 
LEU CB   C N N 260 
LEU CG   C N N 261 
LEU CD1  C N N 262 
LEU CD2  C N N 263 
LEU OXT  O N N 264 
LEU H    H N N 265 
LEU H2   H N N 266 
LEU HA   H N N 267 
LEU HB2  H N N 268 
LEU HB3  H N N 269 
LEU HG   H N N 270 
LEU HD11 H N N 271 
LEU HD12 H N N 272 
LEU HD13 H N N 273 
LEU HD21 H N N 274 
LEU HD22 H N N 275 
LEU HD23 H N N 276 
LEU HXT  H N N 277 
LYS N    N N N 278 
LYS CA   C N S 279 
LYS C    C N N 280 
LYS O    O N N 281 
LYS CB   C N N 282 
LYS CG   C N N 283 
LYS CD   C N N 284 
LYS CE   C N N 285 
LYS NZ   N N N 286 
LYS OXT  O N N 287 
LYS H    H N N 288 
LYS H2   H N N 289 
LYS HA   H N N 290 
LYS HB2  H N N 291 
LYS HB3  H N N 292 
LYS HG2  H N N 293 
LYS HG3  H N N 294 
LYS HD2  H N N 295 
LYS HD3  H N N 296 
LYS HE2  H N N 297 
LYS HE3  H N N 298 
LYS HZ1  H N N 299 
LYS HZ2  H N N 300 
LYS HZ3  H N N 301 
LYS HXT  H N N 302 
MET N    N N N 303 
MET CA   C N S 304 
MET C    C N N 305 
MET O    O N N 306 
MET CB   C N N 307 
MET CG   C N N 308 
MET SD   S N N 309 
MET CE   C N N 310 
MET OXT  O N N 311 
MET H    H N N 312 
MET H2   H N N 313 
MET HA   H N N 314 
MET HB2  H N N 315 
MET HB3  H N N 316 
MET HG2  H N N 317 
MET HG3  H N N 318 
MET HE1  H N N 319 
MET HE2  H N N 320 
MET HE3  H N N 321 
MET HXT  H N N 322 
PHE N    N N N 323 
PHE CA   C N S 324 
PHE C    C N N 325 
PHE O    O N N 326 
PHE CB   C N N 327 
PHE CG   C Y N 328 
PHE CD1  C Y N 329 
PHE CD2  C Y N 330 
PHE CE1  C Y N 331 
PHE CE2  C Y N 332 
PHE CZ   C Y N 333 
PHE OXT  O N N 334 
PHE H    H N N 335 
PHE H2   H N N 336 
PHE HA   H N N 337 
PHE HB2  H N N 338 
PHE HB3  H N N 339 
PHE HD1  H N N 340 
PHE HD2  H N N 341 
PHE HE1  H N N 342 
PHE HE2  H N N 343 
PHE HZ   H N N 344 
PHE HXT  H N N 345 
PRO N    N N N 346 
PRO CA   C N S 347 
PRO C    C N N 348 
PRO O    O N N 349 
PRO CB   C N N 350 
PRO CG   C N N 351 
PRO CD   C N N 352 
PRO OXT  O N N 353 
PRO H    H N N 354 
PRO HA   H N N 355 
PRO HB2  H N N 356 
PRO HB3  H N N 357 
PRO HG2  H N N 358 
PRO HG3  H N N 359 
PRO HD2  H N N 360 
PRO HD3  H N N 361 
PRO HXT  H N N 362 
SER N    N N N 363 
SER CA   C N S 364 
SER C    C N N 365 
SER O    O N N 366 
SER CB   C N N 367 
SER OG   O N N 368 
SER OXT  O N N 369 
SER H    H N N 370 
SER H2   H N N 371 
SER HA   H N N 372 
SER HB2  H N N 373 
SER HB3  H N N 374 
SER HG   H N N 375 
SER HXT  H N N 376 
THR N    N N N 377 
THR CA   C N S 378 
THR C    C N N 379 
THR O    O N N 380 
THR CB   C N R 381 
THR OG1  O N N 382 
THR CG2  C N N 383 
THR OXT  O N N 384 
THR H    H N N 385 
THR H2   H N N 386 
THR HA   H N N 387 
THR HB   H N N 388 
THR HG1  H N N 389 
THR HG21 H N N 390 
THR HG22 H N N 391 
THR HG23 H N N 392 
THR HXT  H N N 393 
TRP N    N N N 394 
TRP CA   C N S 395 
TRP C    C N N 396 
TRP O    O N N 397 
TRP CB   C N N 398 
TRP CG   C Y N 399 
TRP CD1  C Y N 400 
TRP CD2  C Y N 401 
TRP NE1  N Y N 402 
TRP CE2  C Y N 403 
TRP CE3  C Y N 404 
TRP CZ2  C Y N 405 
TRP CZ3  C Y N 406 
TRP CH2  C Y N 407 
TRP OXT  O N N 408 
TRP H    H N N 409 
TRP H2   H N N 410 
TRP HA   H N N 411 
TRP HB2  H N N 412 
TRP HB3  H N N 413 
TRP HD1  H N N 414 
TRP HE1  H N N 415 
TRP HE3  H N N 416 
TRP HZ2  H N N 417 
TRP HZ3  H N N 418 
TRP HH2  H N N 419 
TRP HXT  H N N 420 
TYR N    N N N 421 
TYR CA   C N S 422 
TYR C    C N N 423 
TYR O    O N N 424 
TYR CB   C N N 425 
TYR CG   C Y N 426 
TYR CD1  C Y N 427 
TYR CD2  C Y N 428 
TYR CE1  C Y N 429 
TYR CE2  C Y N 430 
TYR CZ   C Y N 431 
TYR OH   O N N 432 
TYR OXT  O N N 433 
TYR H    H N N 434 
TYR H2   H N N 435 
TYR HA   H N N 436 
TYR HB2  H N N 437 
TYR HB3  H N N 438 
TYR HD1  H N N 439 
TYR HD2  H N N 440 
TYR HE1  H N N 441 
TYR HE2  H N N 442 
TYR HH   H N N 443 
TYR HXT  H N N 444 
VAL N    N N N 445 
VAL CA   C N S 446 
VAL C    C N N 447 
VAL O    O N N 448 
VAL CB   C N N 449 
VAL CG1  C N N 450 
VAL CG2  C N N 451 
VAL OXT  O N N 452 
VAL H    H N N 453 
VAL H2   H N N 454 
VAL HA   H N N 455 
VAL HB   H N N 456 
VAL HG11 H N N 457 
VAL HG12 H N N 458 
VAL HG13 H N N 459 
VAL HG21 H N N 460 
VAL HG22 H N N 461 
VAL HG23 H N N 462 
VAL HXT  H N N 463 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
117 C17 C12  doub Y N 1   
117 C17 C16  sing Y N 2   
117 C17 H17  sing N N 3   
117 C12 C13  sing Y N 4   
117 C12 C10  sing Y N 5   
117 C13 C14  doub Y N 6   
117 C13 H13  sing N N 7   
117 C14 C15  sing Y N 8   
117 C14 H14  sing N N 9   
117 C15 C16  doub Y N 10  
117 C15 H15  sing N N 11  
117 C16 H16  sing N N 12  
117 C83 C82  doub Y N 13  
117 C83 C84  sing Y N 14  
117 C83 H83  sing N N 15  
117 C82 C81  sing Y N 16  
117 C82 H82  sing N N 17  
117 C81 C86  doub Y N 18  
117 C81 C8   sing Y N 19  
117 C86 C85  sing Y N 20  
117 C86 H86  sing N N 21  
117 C85 C84  doub Y N 22  
117 C85 H85  sing N N 23  
117 C84 F1   sing N N 24  
117 C8  N1   sing Y N 25  
117 C8  C10  doub Y N 26  
117 C19 C20  doub Y N 27  
117 C19 C24  sing Y N 28  
117 C19 N2   sing N N 29  
117 C20 C21  sing Y N 30  
117 C20 H20  sing N N 31  
117 C21 C22  doub Y N 32  
117 C21 H21  sing N N 33  
117 C22 C23  sing Y N 34  
117 C22 H22  sing N N 35  
117 C23 C24  doub Y N 36  
117 C23 H23  sing N N 37  
117 C24 H24  sing N N 38  
117 O1B C1   sing N N 39  
117 O1B H1B  sing N N 40  
117 O1A C1   doub N N 41  
117 O3  C3   sing N N 42  
117 O3  HO3  sing N N 43  
117 C1  C2   sing N N 44  
117 C2  C3   sing N N 45  
117 C2  H21A sing N N 46  
117 C2  H22A sing N N 47  
117 C3  C4   sing N N 48  
117 C3  H3   sing N N 49  
117 C4  C5   sing N N 50  
117 C4  H41  sing N N 51  
117 C4  H42  sing N N 52  
117 C5  C6   sing N N 53  
117 C5  O5   sing N N 54  
117 C5  H5   sing N N 55  
117 C6  C7   sing N N 56  
117 C6  H61  sing N N 57  
117 C6  H62  sing N N 58  
117 C7  N1   sing N N 59  
117 C7  H71  sing N N 60  
117 C7  H72  sing N N 61  
117 N1  C9   sing Y N 62  
117 C10 C11  sing Y N 63  
117 C11 C18  sing N N 64  
117 C11 C9   doub Y N 65  
117 C18 N2   sing N N 66  
117 C18 O18  doub N N 67  
117 N2  HN2  sing N N 68  
117 C9  C91  sing N N 69  
117 C91 C93  sing N N 70  
117 C91 C92  sing N N 71  
117 C91 H91  sing N N 72  
117 C93 H931 sing N N 73  
117 C93 H932 sing N N 74  
117 C93 H933 sing N N 75  
117 C92 H921 sing N N 76  
117 C92 H922 sing N N 77  
117 C92 H923 sing N N 78  
117 O5  HO5  sing N N 79  
ALA N   CA   sing N N 80  
ALA N   H    sing N N 81  
ALA N   H2   sing N N 82  
ALA CA  C    sing N N 83  
ALA CA  CB   sing N N 84  
ALA CA  HA   sing N N 85  
ALA C   O    doub N N 86  
ALA C   OXT  sing N N 87  
ALA CB  HB1  sing N N 88  
ALA CB  HB2  sing N N 89  
ALA CB  HB3  sing N N 90  
ALA OXT HXT  sing N N 91  
ARG N   CA   sing N N 92  
ARG N   H    sing N N 93  
ARG N   H2   sing N N 94  
ARG CA  C    sing N N 95  
ARG CA  CB   sing N N 96  
ARG CA  HA   sing N N 97  
ARG C   O    doub N N 98  
ARG C   OXT  sing N N 99  
ARG CB  CG   sing N N 100 
ARG CB  HB2  sing N N 101 
ARG CB  HB3  sing N N 102 
ARG CG  CD   sing N N 103 
ARG CG  HG2  sing N N 104 
ARG CG  HG3  sing N N 105 
ARG CD  NE   sing N N 106 
ARG CD  HD2  sing N N 107 
ARG CD  HD3  sing N N 108 
ARG NE  CZ   sing N N 109 
ARG NE  HE   sing N N 110 
ARG CZ  NH1  sing N N 111 
ARG CZ  NH2  doub N N 112 
ARG NH1 HH11 sing N N 113 
ARG NH1 HH12 sing N N 114 
ARG NH2 HH21 sing N N 115 
ARG NH2 HH22 sing N N 116 
ARG OXT HXT  sing N N 117 
ASN N   CA   sing N N 118 
ASN N   H    sing N N 119 
ASN N   H2   sing N N 120 
ASN CA  C    sing N N 121 
ASN CA  CB   sing N N 122 
ASN CA  HA   sing N N 123 
ASN C   O    doub N N 124 
ASN C   OXT  sing N N 125 
ASN CB  CG   sing N N 126 
ASN CB  HB2  sing N N 127 
ASN CB  HB3  sing N N 128 
ASN CG  OD1  doub N N 129 
ASN CG  ND2  sing N N 130 
ASN ND2 HD21 sing N N 131 
ASN ND2 HD22 sing N N 132 
ASN OXT HXT  sing N N 133 
ASP N   CA   sing N N 134 
ASP N   H    sing N N 135 
ASP N   H2   sing N N 136 
ASP CA  C    sing N N 137 
ASP CA  CB   sing N N 138 
ASP CA  HA   sing N N 139 
ASP C   O    doub N N 140 
ASP C   OXT  sing N N 141 
ASP CB  CG   sing N N 142 
ASP CB  HB2  sing N N 143 
ASP CB  HB3  sing N N 144 
ASP CG  OD1  doub N N 145 
ASP CG  OD2  sing N N 146 
ASP OD2 HD2  sing N N 147 
ASP OXT HXT  sing N N 148 
CYS N   CA   sing N N 149 
CYS N   H    sing N N 150 
CYS N   H2   sing N N 151 
CYS CA  C    sing N N 152 
CYS CA  CB   sing N N 153 
CYS CA  HA   sing N N 154 
CYS C   O    doub N N 155 
CYS C   OXT  sing N N 156 
CYS CB  SG   sing N N 157 
CYS CB  HB2  sing N N 158 
CYS CB  HB3  sing N N 159 
CYS SG  HG   sing N N 160 
CYS OXT HXT  sing N N 161 
GLN N   CA   sing N N 162 
GLN N   H    sing N N 163 
GLN N   H2   sing N N 164 
GLN CA  C    sing N N 165 
GLN CA  CB   sing N N 166 
GLN CA  HA   sing N N 167 
GLN C   O    doub N N 168 
GLN C   OXT  sing N N 169 
GLN CB  CG   sing N N 170 
GLN CB  HB2  sing N N 171 
GLN CB  HB3  sing N N 172 
GLN CG  CD   sing N N 173 
GLN CG  HG2  sing N N 174 
GLN CG  HG3  sing N N 175 
GLN CD  OE1  doub N N 176 
GLN CD  NE2  sing N N 177 
GLN NE2 HE21 sing N N 178 
GLN NE2 HE22 sing N N 179 
GLN OXT HXT  sing N N 180 
GLU N   CA   sing N N 181 
GLU N   H    sing N N 182 
GLU N   H2   sing N N 183 
GLU CA  C    sing N N 184 
GLU CA  CB   sing N N 185 
GLU CA  HA   sing N N 186 
GLU C   O    doub N N 187 
GLU C   OXT  sing N N 188 
GLU CB  CG   sing N N 189 
GLU CB  HB2  sing N N 190 
GLU CB  HB3  sing N N 191 
GLU CG  CD   sing N N 192 
GLU CG  HG2  sing N N 193 
GLU CG  HG3  sing N N 194 
GLU CD  OE1  doub N N 195 
GLU CD  OE2  sing N N 196 
GLU OE2 HE2  sing N N 197 
GLU OXT HXT  sing N N 198 
GLY N   CA   sing N N 199 
GLY N   H    sing N N 200 
GLY N   H2   sing N N 201 
GLY CA  C    sing N N 202 
GLY CA  HA2  sing N N 203 
GLY CA  HA3  sing N N 204 
GLY C   O    doub N N 205 
GLY C   OXT  sing N N 206 
GLY OXT HXT  sing N N 207 
HIS N   CA   sing N N 208 
HIS N   H    sing N N 209 
HIS N   H2   sing N N 210 
HIS CA  C    sing N N 211 
HIS CA  CB   sing N N 212 
HIS CA  HA   sing N N 213 
HIS C   O    doub N N 214 
HIS C   OXT  sing N N 215 
HIS CB  CG   sing N N 216 
HIS CB  HB2  sing N N 217 
HIS CB  HB3  sing N N 218 
HIS CG  ND1  sing Y N 219 
HIS CG  CD2  doub Y N 220 
HIS ND1 CE1  doub Y N 221 
HIS ND1 HD1  sing N N 222 
HIS CD2 NE2  sing Y N 223 
HIS CD2 HD2  sing N N 224 
HIS CE1 NE2  sing Y N 225 
HIS CE1 HE1  sing N N 226 
HIS NE2 HE2  sing N N 227 
HIS OXT HXT  sing N N 228 
ILE N   CA   sing N N 229 
ILE N   H    sing N N 230 
ILE N   H2   sing N N 231 
ILE CA  C    sing N N 232 
ILE CA  CB   sing N N 233 
ILE CA  HA   sing N N 234 
ILE C   O    doub N N 235 
ILE C   OXT  sing N N 236 
ILE CB  CG1  sing N N 237 
ILE CB  CG2  sing N N 238 
ILE CB  HB   sing N N 239 
ILE CG1 CD1  sing N N 240 
ILE CG1 HG12 sing N N 241 
ILE CG1 HG13 sing N N 242 
ILE CG2 HG21 sing N N 243 
ILE CG2 HG22 sing N N 244 
ILE CG2 HG23 sing N N 245 
ILE CD1 HD11 sing N N 246 
ILE CD1 HD12 sing N N 247 
ILE CD1 HD13 sing N N 248 
ILE OXT HXT  sing N N 249 
LEU N   CA   sing N N 250 
LEU N   H    sing N N 251 
LEU N   H2   sing N N 252 
LEU CA  C    sing N N 253 
LEU CA  CB   sing N N 254 
LEU CA  HA   sing N N 255 
LEU C   O    doub N N 256 
LEU C   OXT  sing N N 257 
LEU CB  CG   sing N N 258 
LEU CB  HB2  sing N N 259 
LEU CB  HB3  sing N N 260 
LEU CG  CD1  sing N N 261 
LEU CG  CD2  sing N N 262 
LEU CG  HG   sing N N 263 
LEU CD1 HD11 sing N N 264 
LEU CD1 HD12 sing N N 265 
LEU CD1 HD13 sing N N 266 
LEU CD2 HD21 sing N N 267 
LEU CD2 HD22 sing N N 268 
LEU CD2 HD23 sing N N 269 
LEU OXT HXT  sing N N 270 
LYS N   CA   sing N N 271 
LYS N   H    sing N N 272 
LYS N   H2   sing N N 273 
LYS CA  C    sing N N 274 
LYS CA  CB   sing N N 275 
LYS CA  HA   sing N N 276 
LYS C   O    doub N N 277 
LYS C   OXT  sing N N 278 
LYS CB  CG   sing N N 279 
LYS CB  HB2  sing N N 280 
LYS CB  HB3  sing N N 281 
LYS CG  CD   sing N N 282 
LYS CG  HG2  sing N N 283 
LYS CG  HG3  sing N N 284 
LYS CD  CE   sing N N 285 
LYS CD  HD2  sing N N 286 
LYS CD  HD3  sing N N 287 
LYS CE  NZ   sing N N 288 
LYS CE  HE2  sing N N 289 
LYS CE  HE3  sing N N 290 
LYS NZ  HZ1  sing N N 291 
LYS NZ  HZ2  sing N N 292 
LYS NZ  HZ3  sing N N 293 
LYS OXT HXT  sing N N 294 
MET N   CA   sing N N 295 
MET N   H    sing N N 296 
MET N   H2   sing N N 297 
MET CA  C    sing N N 298 
MET CA  CB   sing N N 299 
MET CA  HA   sing N N 300 
MET C   O    doub N N 301 
MET C   OXT  sing N N 302 
MET CB  CG   sing N N 303 
MET CB  HB2  sing N N 304 
MET CB  HB3  sing N N 305 
MET CG  SD   sing N N 306 
MET CG  HG2  sing N N 307 
MET CG  HG3  sing N N 308 
MET SD  CE   sing N N 309 
MET CE  HE1  sing N N 310 
MET CE  HE2  sing N N 311 
MET CE  HE3  sing N N 312 
MET OXT HXT  sing N N 313 
PHE N   CA   sing N N 314 
PHE N   H    sing N N 315 
PHE N   H2   sing N N 316 
PHE CA  C    sing N N 317 
PHE CA  CB   sing N N 318 
PHE CA  HA   sing N N 319 
PHE C   O    doub N N 320 
PHE C   OXT  sing N N 321 
PHE CB  CG   sing N N 322 
PHE CB  HB2  sing N N 323 
PHE CB  HB3  sing N N 324 
PHE CG  CD1  doub Y N 325 
PHE CG  CD2  sing Y N 326 
PHE CD1 CE1  sing Y N 327 
PHE CD1 HD1  sing N N 328 
PHE CD2 CE2  doub Y N 329 
PHE CD2 HD2  sing N N 330 
PHE CE1 CZ   doub Y N 331 
PHE CE1 HE1  sing N N 332 
PHE CE2 CZ   sing Y N 333 
PHE CE2 HE2  sing N N 334 
PHE CZ  HZ   sing N N 335 
PHE OXT HXT  sing N N 336 
PRO N   CA   sing N N 337 
PRO N   CD   sing N N 338 
PRO N   H    sing N N 339 
PRO CA  C    sing N N 340 
PRO CA  CB   sing N N 341 
PRO CA  HA   sing N N 342 
PRO C   O    doub N N 343 
PRO C   OXT  sing N N 344 
PRO CB  CG   sing N N 345 
PRO CB  HB2  sing N N 346 
PRO CB  HB3  sing N N 347 
PRO CG  CD   sing N N 348 
PRO CG  HG2  sing N N 349 
PRO CG  HG3  sing N N 350 
PRO CD  HD2  sing N N 351 
PRO CD  HD3  sing N N 352 
PRO OXT HXT  sing N N 353 
SER N   CA   sing N N 354 
SER N   H    sing N N 355 
SER N   H2   sing N N 356 
SER CA  C    sing N N 357 
SER CA  CB   sing N N 358 
SER CA  HA   sing N N 359 
SER C   O    doub N N 360 
SER C   OXT  sing N N 361 
SER CB  OG   sing N N 362 
SER CB  HB2  sing N N 363 
SER CB  HB3  sing N N 364 
SER OG  HG   sing N N 365 
SER OXT HXT  sing N N 366 
THR N   CA   sing N N 367 
THR N   H    sing N N 368 
THR N   H2   sing N N 369 
THR CA  C    sing N N 370 
THR CA  CB   sing N N 371 
THR CA  HA   sing N N 372 
THR C   O    doub N N 373 
THR C   OXT  sing N N 374 
THR CB  OG1  sing N N 375 
THR CB  CG2  sing N N 376 
THR CB  HB   sing N N 377 
THR OG1 HG1  sing N N 378 
THR CG2 HG21 sing N N 379 
THR CG2 HG22 sing N N 380 
THR CG2 HG23 sing N N 381 
THR OXT HXT  sing N N 382 
TRP N   CA   sing N N 383 
TRP N   H    sing N N 384 
TRP N   H2   sing N N 385 
TRP CA  C    sing N N 386 
TRP CA  CB   sing N N 387 
TRP CA  HA   sing N N 388 
TRP C   O    doub N N 389 
TRP C   OXT  sing N N 390 
TRP CB  CG   sing N N 391 
TRP CB  HB2  sing N N 392 
TRP CB  HB3  sing N N 393 
TRP CG  CD1  doub Y N 394 
TRP CG  CD2  sing Y N 395 
TRP CD1 NE1  sing Y N 396 
TRP CD1 HD1  sing N N 397 
TRP CD2 CE2  doub Y N 398 
TRP CD2 CE3  sing Y N 399 
TRP NE1 CE2  sing Y N 400 
TRP NE1 HE1  sing N N 401 
TRP CE2 CZ2  sing Y N 402 
TRP CE3 CZ3  doub Y N 403 
TRP CE3 HE3  sing N N 404 
TRP CZ2 CH2  doub Y N 405 
TRP CZ2 HZ2  sing N N 406 
TRP CZ3 CH2  sing Y N 407 
TRP CZ3 HZ3  sing N N 408 
TRP CH2 HH2  sing N N 409 
TRP OXT HXT  sing N N 410 
TYR N   CA   sing N N 411 
TYR N   H    sing N N 412 
TYR N   H2   sing N N 413 
TYR CA  C    sing N N 414 
TYR CA  CB   sing N N 415 
TYR CA  HA   sing N N 416 
TYR C   O    doub N N 417 
TYR C   OXT  sing N N 418 
TYR CB  CG   sing N N 419 
TYR CB  HB2  sing N N 420 
TYR CB  HB3  sing N N 421 
TYR CG  CD1  doub Y N 422 
TYR CG  CD2  sing Y N 423 
TYR CD1 CE1  sing Y N 424 
TYR CD1 HD1  sing N N 425 
TYR CD2 CE2  doub Y N 426 
TYR CD2 HD2  sing N N 427 
TYR CE1 CZ   doub Y N 428 
TYR CE1 HE1  sing N N 429 
TYR CE2 CZ   sing Y N 430 
TYR CE2 HE2  sing N N 431 
TYR CZ  OH   sing N N 432 
TYR OH  HH   sing N N 433 
TYR OXT HXT  sing N N 434 
VAL N   CA   sing N N 435 
VAL N   H    sing N N 436 
VAL N   H2   sing N N 437 
VAL CA  C    sing N N 438 
VAL CA  CB   sing N N 439 
VAL CA  HA   sing N N 440 
VAL C   O    doub N N 441 
VAL C   OXT  sing N N 442 
VAL CB  CG1  sing N N 443 
VAL CB  CG2  sing N N 444 
VAL CB  HB   sing N N 445 
VAL CG1 HG11 sing N N 446 
VAL CG1 HG12 sing N N 447 
VAL CG1 HG13 sing N N 448 
VAL CG2 HG21 sing N N 449 
VAL CG2 HG22 sing N N 450 
VAL CG2 HG23 sing N N 451 
VAL OXT HXT  sing N N 452 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-06-27 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           8PKN 
_em_admin.last_update        2025-03-12 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              'CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                KILODALTONS/NANOMETER 
_em_entity_assembly_molwt.value                214 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         42 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     18337 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   3061130 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? Topaz  0.2.4 
'IMAGE ACQUISITION'             ? 2  ? ? 1 EPU    3.5   
MASKING                         ? 3  ? ? ? ?      ?     
'CTF CORRECTION'                ? 4  1 ? ? RELION 4.0   
'LAYERLINE INDEXING'            ? 5  ? ? ? ?      ?     
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?      ?     
'MODEL FITTING'                 ? 7  ? 1 ? Coot   0.8.9 
OTHER                           ? 8  ? ? ? ?      ?     
'INITIAL EULER ASSIGNMENT'      ? 9  1 ? ? RELION 4.0   
'FINAL EULER ASSIGNMENT'        ? 10 1 ? ? RELION 4.0   
CLASSIFICATION                  ? 11 1 ? ? RELION 4.0   
RECONSTRUCTION                  ? 12 1 ? ? RELION 4.0   
'MODEL REFINEMENT'              ? 13 ? 1 ? REFMAC ?     
'VOLUME SELECTION'              ? 14 1 1 1 ?      ?     
'SERIES ALIGNMENT'              ? 15 1 1 1 ?      ?     
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?      ?     
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?      ?     
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?      ?     
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?      ?     
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Diamond Light Source' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1hwk 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8PKN 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
F ?  ?  ?       ?       ?      ?       ?      ?       ?      ?       ?        
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 0.8669   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 1   ? 163.455 77.337  88.984  1 137.546 ? 439 PRO A N   1 
ATOM   2    C CA  . PRO A 1 1   ? 162     77.152  89.306  1 140.97  ? 439 PRO A CA  1 
ATOM   3    C C   . PRO A 1 1   ? 161.819 76.048  90.346  1 154.143 ? 439 PRO A C   1 
ATOM   4    O O   . PRO A 1 1   ? 162.729 75.761  91.127  1 159.83  ? 439 PRO A O   1 
ATOM   5    C CB  . PRO A 1 1   ? 161.362 76.799  87.96   1 139.126 ? 439 PRO A CB  1 
ATOM   6    C CG  . PRO A 1 1   ? 162.169 77.649  86.985  1 144.666 ? 439 PRO A CG  1 
ATOM   7    C CD  . PRO A 1 1   ? 163.578 77.677  87.523  1 137.679 ? 439 PRO A CD  1 
ATOM   8    N N   . ARG A 1 2   ? 160.626 75.44   90.356  1 145.254 ? 440 ARG A N   1 
ATOM   9    C CA  . ARG A 1 2   ? 160.34  74.333  91.255  1 140.073 ? 440 ARG A CA  1 
ATOM   10   C C   . ARG A 1 2   ? 159.084 73.615  90.764  1 143.828 ? 440 ARG A C   1 
ATOM   11   O O   . ARG A 1 2   ? 158.35  74.14   89.923  1 147.965 ? 440 ARG A O   1 
ATOM   12   C CB  . ARG A 1 2   ? 160.121 74.84   92.685  1 136.984 ? 440 ARG A CB  1 
ATOM   13   C CG  . ARG A 1 2   ? 160.361 73.8    93.77   1 144.444 ? 440 ARG A CG  1 
ATOM   14   C CD  . ARG A 1 2   ? 161.722 73.993  94.431  1 151.169 ? 440 ARG A CD  1 
ATOM   15   N NE  . ARG A 1 2   ? 161.953 72.995  95.481  1 146.461 ? 440 ARG A NE  1 
ATOM   16   C CZ  . ARG A 1 2   ? 161.292 72.927  96.636  1 157.921 ? 440 ARG A CZ  1 
ATOM   17   N NH1 . ARG A 1 2   ? 160.371 73.832  96.948  1 146.074 ? 440 ARG A NH1 1 
ATOM   18   N NH2 . ARG A 1 2   ? 161.584 71.957  97.49   1 153.445 ? 440 ARG A NH2 1 
ATOM   19   N N   . GLU A 1 3   ? 158.848 72.412  91.298  1 133.928 ? 441 GLU A N   1 
ATOM   20   C CA  . GLU A 1 3   ? 157.686 71.628  90.915  1 140.8   ? 441 GLU A CA  1 
ATOM   21   C C   . GLU A 1 3   ? 156.983 71.113  92.168  1 140.806 ? 441 GLU A C   1 
ATOM   22   O O   . GLU A 1 3   ? 157.628 70.829  93.181  1 137.134 ? 441 GLU A O   1 
ATOM   23   C CB  . GLU A 1 3   ? 158.057 70.442  90.024  1 140.845 ? 441 GLU A CB  1 
ATOM   24   C CG  . GLU A 1 3   ? 159.155 70.756  89.009  1 149.663 ? 441 GLU A CG  1 
ATOM   25   C CD  . GLU A 1 3   ? 160.556 70.622  89.591  1 160.084 ? 441 GLU A CD  1 
ATOM   26   O OE1 . GLU A 1 3   ? 160.868 71.361  90.557  1 133.385 ? 441 GLU A OE1 1 
ATOM   27   O OE2 . GLU A 1 3   ? 161.323 69.756  89.093  1 152.474 ? 441 GLU A OE2 1 
ATOM   28   N N   . PRO A 1 4   ? 155.639 70.978  92.139  1 127.296 ? 442 PRO A N   1 
ATOM   29   C CA  . PRO A 1 4   ? 154.911 70.459  93.287  1 130.384 ? 442 PRO A CA  1 
ATOM   30   C C   . PRO A 1 4   ? 155.407 69.084  93.724  1 132.077 ? 442 PRO A C   1 
ATOM   31   O O   . PRO A 1 4   ? 155.741 68.243  92.89   1 135.048 ? 442 PRO A O   1 
ATOM   32   C CB  . PRO A 1 4   ? 153.458 70.383  92.806  1 127.204 ? 442 PRO A CB  1 
ATOM   33   C CG  . PRO A 1 4   ? 153.403 71.379  91.658  1 129.644 ? 442 PRO A CG  1 
ATOM   34   C CD  . PRO A 1 4   ? 154.76  71.335  91.013  1 132.506 ? 442 PRO A CD  1 
ATOM   35   N N   . ARG A 1 5   ? 155.441 68.877  95.043  1 125.156 ? 443 ARG A N   1 
ATOM   36   C CA  . ARG A 1 5   ? 155.769 67.585  95.615  1 117.373 ? 443 ARG A CA  1 
ATOM   37   C C   . ARG A 1 5   ? 154.505 66.735  95.689  1 125.884 ? 443 ARG A C   1 
ATOM   38   O O   . ARG A 1 5   ? 153.393 67.263  95.67   1 125.621 ? 443 ARG A O   1 
ATOM   39   C CB  . ARG A 1 5   ? 156.347 67.782  97.018  1 130.767 ? 443 ARG A CB  1 
ATOM   40   C CG  . ARG A 1 5   ? 157.388 68.896  97.075  1 126.545 ? 443 ARG A CG  1 
ATOM   41   C CD  . ARG A 1 5   ? 158.371 68.685  98.217  1 125.323 ? 443 ARG A CD  1 
ATOM   42   N NE  . ARG A 1 5   ? 158.07  69.482  99.41   1 138.602 ? 443 ARG A NE  1 
ATOM   43   C CZ  . ARG A 1 5   ? 158.367 70.772  99.549  1 139.764 ? 443 ARG A CZ  1 
ATOM   44   N NH1 . ARG A 1 5   ? 158.923 71.446  98.55   1 136.037 ? 443 ARG A NH1 1 
ATOM   45   N NH2 . ARG A 1 5   ? 158.114 71.384  100.694 1 137.456 ? 443 ARG A NH2 1 
ATOM   46   N N   . PRO A 1 6   ? 154.624 65.389  95.741  1 129.818 ? 444 PRO A N   1 
ATOM   47   C CA  . PRO A 1 6   ? 153.447 64.535  95.866  1 126.858 ? 444 PRO A CA  1 
ATOM   48   C C   . PRO A 1 6   ? 152.469 64.986  96.95   1 128.316 ? 444 PRO A C   1 
ATOM   49   O O   . PRO A 1 6   ? 152.815 65.758  97.845  1 117.486 ? 444 PRO A O   1 
ATOM   50   C CB  . PRO A 1 6   ? 154.01  63.145  96.173  1 132.062 ? 444 PRO A CB  1 
ATOM   51   C CG  . PRO A 1 6   ? 155.53  63.262  96.086  1 133.569 ? 444 PRO A CG  1 
ATOM   52   C CD  . PRO A 1 6   ? 155.876 64.633  95.567  1 127.274 ? 444 PRO A CD  1 
ATOM   53   N N   . ASN A 1 7   ? 151.244 64.46   96.862  1 130.563 ? 445 ASN A N   1 
ATOM   54   C CA  . ASN A 1 7   ? 150.176 64.832  97.777  1 130.925 ? 445 ASN A CA  1 
ATOM   55   C C   . ASN A 1 7   ? 150.355 64.181  99.149  1 146.278 ? 445 ASN A C   1 
ATOM   56   O O   . ASN A 1 7   ? 150.011 64.795  100.16  1 148.86  ? 445 ASN A O   1 
ATOM   57   C CB  . ASN A 1 7   ? 148.801 64.477  97.219  1 132.784 ? 445 ASN A CB  1 
ATOM   58   C CG  . ASN A 1 7   ? 148.124 65.653  96.553  1 141.027 ? 445 ASN A CG  1 
ATOM   59   O OD1 . ASN A 1 7   ? 148.762 66.678  96.27   1 136.312 ? 445 ASN A OD1 1 
ATOM   60   N ND2 . ASN A 1 7   ? 146.834 65.514  96.282  1 124.079 ? 445 ASN A ND2 1 
ATOM   61   N N   . GLU A 1 8   ? 150.834 62.929  99.188  1 130.762 ? 446 GLU A N   1 
ATOM   62   C CA  . GLU A 1 8   ? 151.008 62.235  100.458 1 133.574 ? 446 GLU A CA  1 
ATOM   63   C C   . GLU A 1 8   ? 152.012 62.992  101.329 1 132.387 ? 446 GLU A C   1 
ATOM   64   O O   . GLU A 1 8   ? 151.81  63.145  102.537 1 128.697 ? 446 GLU A O   1 
ATOM   65   C CB  . GLU A 1 8   ? 151.467 60.793  100.233 1 136.22  ? 446 GLU A CB  1 
ATOM   66   C CG  . GLU A 1 8   ? 150.421 59.924  99.536  1 136.828 ? 446 GLU A CG  1 
ATOM   67   C CD  . GLU A 1 8   ? 149.444 59.197  100.451 1 148.935 ? 446 GLU A CD  1 
ATOM   68   O OE1 . GLU A 1 8   ? 148.391 58.743  99.927  1 136.366 ? 446 GLU A OE1 1 
ATOM   69   O OE2 . GLU A 1 8   ? 149.736 59.038  101.663 1 136.674 ? 446 GLU A OE2 1 
ATOM   70   N N   . GLU A 1 9   ? 153.11  63.44   100.707 1 124.404 ? 447 GLU A N   1 
ATOM   71   C CA  . GLU A 1 9   ? 153.98  64.43   101.318 1 121.995 ? 447 GLU A CA  1 
ATOM   72   C C   . GLU A 1 9   ? 153.208 65.746  101.3   1 141.386 ? 447 GLU A C   1 
ATOM   73   O O   . GLU A 1 9   ? 152.053 65.77   100.877 1 146.142 ? 447 GLU A O   1 
ATOM   74   C CB  . GLU A 1 9   ? 155.312 64.459  100.566 1 133.663 ? 447 GLU A CB  1 
ATOM   75   C CG  . GLU A 1 9   ? 156.233 65.609  100.968 1 129.042 ? 447 GLU A CG  1 
ATOM   76   C CD  . GLU A 1 9   ? 157.682 65.367  100.589 1 146.905 ? 447 GLU A CD  1 
ATOM   77   O OE1 . GLU A 1 9   ? 157.945 65.051  99.401  1 150.564 ? 447 GLU A OE1 1 
ATOM   78   O OE2 . GLU A 1 9   ? 158.546 65.488  101.494 1 142.072 ? 447 GLU A OE2 1 
ATOM   79   N N   . CYS A 1 10  ? 153.805 66.829  101.808 1 130.4   ? 448 CYS A N   1 
ATOM   80   C CA  . CYS A 1 10  ? 153.158 68.131  101.766 1 127.738 ? 448 CYS A CA  1 
ATOM   81   C C   . CYS A 1 10  ? 152.052 68.219  102.816 1 131.883 ? 448 CYS A C   1 
ATOM   82   O O   . CYS A 1 10  ? 151.609 69.317  103.139 1 141.917 ? 448 CYS A O   1 
ATOM   83   C CB  . CYS A 1 10  ? 152.592 68.46   100.387 1 125.84  ? 448 CYS A CB  1 
ATOM   84   S SG  . CYS A 1 10  ? 153.696 69.508  99.405  1 134.38  ? 448 CYS A SG  1 
ATOM   85   N N   . LEU A 1 11  ? 151.603 67.074  103.343 1 128.622 ? 449 LEU A N   1 
ATOM   86   C CA  . LEU A 1 11  ? 150.795 67.077  104.552 1 131.082 ? 449 LEU A CA  1 
ATOM   87   C C   . LEU A 1 11  ? 151.698 66.919  105.775 1 141.214 ? 449 LEU A C   1 
ATOM   88   O O   . LEU A 1 11  ? 151.367 67.413  106.853 1 149.882 ? 449 LEU A O   1 
ATOM   89   C CB  . LEU A 1 11  ? 149.766 65.956  104.485 1 125.705 ? 449 LEU A CB  1 
ATOM   90   C CG  . LEU A 1 11  ? 148.683 66.122  103.417 1 135.07  ? 449 LEU A CG  1 
ATOM   91   C CD1 . LEU A 1 11  ? 148.019 64.779  103.13  1 141.532 ? 449 LEU A CD1 1 
ATOM   92   C CD2 . LEU A 1 11  ? 147.643 67.146  103.851 1 135.406 ? 449 LEU A CD2 1 
ATOM   93   N N   . GLN A 1 12  ? 152.813 66.196  105.611 1 127.294 ? 450 GLN A N   1 
ATOM   94   C CA  . GLN A 1 12  ? 153.858 66.158  106.624 1 126.707 ? 450 GLN A CA  1 
ATOM   95   C C   . GLN A 1 12  ? 154.278 67.584  106.979 1 132.512 ? 450 GLN A C   1 
ATOM   96   O O   . GLN A 1 12  ? 154.314 67.963  108.155 1 147.255 ? 450 GLN A O   1 
ATOM   97   C CB  . GLN A 1 12  ? 155.077 65.371  106.131 1 127.372 ? 450 GLN A CB  1 
ATOM   98   C CG  . GLN A 1 12  ? 155.125 63.931  106.628 1 134.305 ? 450 GLN A CG  1 
ATOM   99   C CD  . GLN A 1 12  ? 155.963 63.038  105.736 1 152.288 ? 450 GLN A CD  1 
ATOM   100  O OE1 . GLN A 1 12  ? 157.097 63.376  105.366 1 141.663 ? 450 GLN A OE1 1 
ATOM   101  N NE2 . GLN A 1 12  ? 155.403 61.891  105.364 1 141.576 ? 450 GLN A NE2 1 
ATOM   102  N N   . ILE A 1 13  ? 154.61  68.371  105.95  1 119.82  ? 451 ILE A N   1 
ATOM   103  C CA  . ILE A 1 13  ? 155.078 69.73   106.17  1 120.833 ? 451 ILE A CA  1 
ATOM   104  C C   . ILE A 1 13  ? 153.94  70.575  106.74  1 128.963 ? 451 ILE A C   1 
ATOM   105  O O   . ILE A 1 13  ? 154.143 71.369  107.655 1 136.587 ? 451 ILE A O   1 
ATOM   106  C CB  . ILE A 1 13  ? 155.644 70.324  104.87  1 121.339 ? 451 ILE A CB  1 
ATOM   107  C CG1 . ILE A 1 13  ? 156.855 69.521  104.378 1 123.046 ? 451 ILE A CG1 1 
ATOM   108  C CG2 . ILE A 1 13  ? 155.992 71.798  105.044 1 121.3   ? 451 ILE A CG2 1 
ATOM   109  C CD1 . ILE A 1 13  ? 156.528 68.507  103.295 1 126.139 ? 451 ILE A CD1 1 
ATOM   110  N N   . LEU A 1 14  ? 152.724 70.386  106.217 1 130.856 ? 452 LEU A N   1 
ATOM   111  C CA  . LEU A 1 14  ? 151.585 71.17   106.677 1 129.774 ? 452 LEU A CA  1 
ATOM   112  C C   . LEU A 1 14  ? 151.383 70.941  108.176 1 137.058 ? 452 LEU A C   1 
ATOM   113  O O   . LEU A 1 14  ? 151.149 71.885  108.931 1 141.205 ? 452 LEU A O   1 
ATOM   114  C CB  . LEU A 1 14  ? 150.355 70.775  105.856 1 132.64  ? 452 LEU A CB  1 
ATOM   115  C CG  . LEU A 1 14  ? 149.064 71.581  106.062 1 129.485 ? 452 LEU A CG  1 
ATOM   116  C CD1 . LEU A 1 14  ? 148.205 70.989  107.179 1 134.636 ? 452 LEU A CD1 1 
ATOM   117  C CD2 . LEU A 1 14  ? 149.334 73.063  106.326 1 122.707 ? 452 LEU A CD2 1 
ATOM   118  N N   . GLY A 1 15  ? 151.511 69.677  108.601 1 154.949 ? 453 GLY A N   1 
ATOM   119  C CA  . GLY A 1 15  ? 151.308 69.291  109.992 1 161.525 ? 453 GLY A CA  1 
ATOM   120  C C   . GLY A 1 15  ? 152.412 69.804  110.92  1 163.354 ? 453 GLY A C   1 
ATOM   121  O O   . GLY A 1 15  ? 152.123 70.258  112.031 1 150.129 ? 453 GLY A O   1 
ATOM   122  N N   . ASN A 1 16  ? 153.673 69.708  110.473 1 148.409 ? 454 ASN A N   1 
ATOM   123  C CA  . ASN A 1 16  ? 154.811 70.02   111.326 1 151.743 ? 454 ASN A CA  1 
ATOM   124  C C   . ASN A 1 16  ? 154.642 71.396  111.968 1 148.181 ? 454 ASN A C   1 
ATOM   125  O O   . ASN A 1 16  ? 154.365 72.379  111.281 1 146.206 ? 454 ASN A O   1 
ATOM   126  C CB  . ASN A 1 16  ? 156.126 69.955  110.553 1 157.938 ? 454 ASN A CB  1 
ATOM   127  C CG  . ASN A 1 16  ? 156.706 68.561  110.551 1 154.765 ? 454 ASN A CG  1 
ATOM   128  O OD1 . ASN A 1 16  ? 156.813 67.941  111.616 1 154.147 ? 454 ASN A OD1 1 
ATOM   129  N ND2 . ASN A 1 16  ? 157.084 68.054  109.384 1 163.68  ? 454 ASN A ND2 1 
ATOM   130  N N   . ALA A 1 17  ? 154.872 71.466  113.287 1 143.779 ? 455 ALA A N   1 
ATOM   131  C CA  . ALA A 1 17  ? 154.69  72.708  114.025 1 141.051 ? 455 ALA A CA  1 
ATOM   132  C C   . ALA A 1 17  ? 155.704 73.76   113.573 1 141.981 ? 455 ALA A C   1 
ATOM   133  O O   . ALA A 1 17  ? 155.376 74.943  113.49  1 151.632 ? 455 ALA A O   1 
ATOM   134  C CB  . ALA A 1 17  ? 154.801 72.445  115.511 1 142.812 ? 455 ALA A CB  1 
ATOM   135  N N   . GLU A 1 18  ? 156.941 73.335  113.296 1 139.729 ? 456 GLU A N   1 
ATOM   136  C CA  . GLU A 1 18  ? 157.991 74.282  112.938 1 146.525 ? 456 GLU A CA  1 
ATOM   137  C C   . GLU A 1 18  ? 158.01  74.458  111.42  1 151.86  ? 456 GLU A C   1 
ATOM   138  O O   . GLU A 1 18  ? 158.063 75.581  110.91  1 164.701 ? 456 GLU A O   1 
ATOM   139  C CB  . GLU A 1 18  ? 159.349 73.817  113.47  1 153.289 ? 456 GLU A CB  1 
ATOM   140  C CG  . GLU A 1 18  ? 160.429 74.901  113.455 1 157.339 ? 456 GLU A CG  1 
ATOM   141  C CD  . GLU A 1 18  ? 160.866 75.363  112.069 1 176.629 ? 456 GLU A CD  1 
ATOM   142  O OE1 . GLU A 1 18  ? 160.465 74.725  111.061 1 155.794 ? 456 GLU A OE1 1 
ATOM   143  O OE2 . GLU A 1 18  ? 161.607 76.376  111.993 1 171.692 ? 456 GLU A OE2 1 
ATOM   144  N N   . LYS A 1 19  ? 157.99  73.33   110.698 1 149.55  ? 457 LYS A N   1 
ATOM   145  C CA  . LYS A 1 19  ? 158.096 73.35   109.246 1 146.078 ? 457 LYS A CA  1 
ATOM   146  C C   . LYS A 1 19  ? 156.695 73.34   108.636 1 141.521 ? 457 LYS A C   1 
ATOM   147  O O   . LYS A 1 19  ? 156.306 72.382  107.965 1 141.086 ? 457 LYS A O   1 
ATOM   148  C CB  . LYS A 1 19  ? 158.936 72.16   108.77  1 136.371 ? 457 LYS A CB  1 
ATOM   149  C CG  . LYS A 1 19  ? 159.377 72.273  107.313 1 142.996 ? 457 LYS A CG  1 
ATOM   150  C CD  . LYS A 1 19  ? 159.674 70.943  106.629 1 142.178 ? 457 LYS A CD  1 
ATOM   151  C CE  . LYS A 1 19  ? 161.111 70.51   106.703 1 141.348 ? 457 LYS A CE  1 
ATOM   152  N NZ  . LYS A 1 19  ? 161.313 69.284  105.919 1 149.969 ? 457 LYS A NZ  1 
ATOM   153  N N   . GLY A 1 20  ? 155.953 74.432  108.858 1 133.689 ? 458 GLY A N   1 
ATOM   154  C CA  . GLY A 1 20  ? 154.56  74.514  108.439 1 138.082 ? 458 GLY A CA  1 
ATOM   155  C C   . GLY A 1 20  ? 154.424 75.133  107.047 1 131.113 ? 458 GLY A C   1 
ATOM   156  O O   . GLY A 1 20  ? 155.318 75.008  106.209 1 125.135 ? 458 GLY A O   1 
ATOM   157  N N   . ALA A 1 21  ? 153.286 75.794  106.798 1 119.703 ? 459 ALA A N   1 
ATOM   158  C CA  . ALA A 1 21  ? 153.147 76.603  105.597 1 120.648 ? 459 ALA A CA  1 
ATOM   159  C C   . ALA A 1 21  ? 154.193 77.719  105.639 1 118.417 ? 459 ALA A C   1 
ATOM   160  O O   . ALA A 1 21  ? 154.865 77.914  106.653 1 119.742 ? 459 ALA A O   1 
ATOM   161  C CB  . ALA A 1 21  ? 151.742 77.143  105.488 1 129.676 ? 459 ALA A CB  1 
ATOM   162  N N   . LYS A 1 22  ? 154.336 78.435  104.522 1 111.404 ? 460 LYS A N   1 
ATOM   163  C CA  . LYS A 1 22  ? 155.469 79.324  104.314 1 115.283 ? 460 LYS A CA  1 
ATOM   164  C C   . LYS A 1 22  ? 156.67  78.512  103.829 1 126.505 ? 460 LYS A C   1 
ATOM   165  O O   . LYS A 1 22  ? 157.676 79.089  103.406 1 130.032 ? 460 LYS A O   1 
ATOM   166  C CB  . LYS A 1 22  ? 155.856 80.107  105.572 1 117.317 ? 460 LYS A CB  1 
ATOM   167  C CG  . LYS A 1 22  ? 156.787 81.289  105.305 1 124.838 ? 460 LYS A CG  1 
ATOM   168  C CD  . LYS A 1 22  ? 157.795 81.514  106.427 1 129.81  ? 460 LYS A CD  1 
ATOM   169  C CE  . LYS A 1 22  ? 157.161 81.868  107.748 1 135.151 ? 460 LYS A CE  1 
ATOM   170  N NZ  . LYS A 1 22  ? 156.852 83.3    107.863 1 140.862 ? 460 LYS A NZ  1 
ATOM   171  N N   . PHE A 1 23  ? 156.554 77.173  103.871 1 111.908 ? 461 PHE A N   1 
ATOM   172  C CA  . PHE A 1 23  ? 157.519 76.298  103.216 1 123.803 ? 461 PHE A CA  1 
ATOM   173  C C   . PHE A 1 23  ? 156.919 75.642  101.974 1 126.604 ? 461 PHE A C   1 
ATOM   174  O O   . PHE A 1 23  ? 157.654 75.288  101.05  1 128.035 ? 461 PHE A O   1 
ATOM   175  C CB  . PHE A 1 23  ? 158.001 75.208  104.172 1 124.75  ? 461 PHE A CB  1 
ATOM   176  C CG  . PHE A 1 23  ? 158.879 75.753  105.284 1 132.13  ? 461 PHE A CG  1 
ATOM   177  C CD1 . PHE A 1 23  ? 160.212 76.069  105.037 1 137.521 ? 461 PHE A CD1 1 
ATOM   178  C CD2 . PHE A 1 23  ? 158.37  75.95   106.563 1 131.474 ? 461 PHE A CD2 1 
ATOM   179  C CE1 . PHE A 1 23  ? 161.02  76.564  106.053 1 145.627 ? 461 PHE A CE1 1 
ATOM   180  C CE2 . PHE A 1 23  ? 159.183 76.438  107.579 1 148.393 ? 461 PHE A CE2 1 
ATOM   181  C CZ  . PHE A 1 23  ? 160.502 76.757  107.32  1 145.498 ? 461 PHE A CZ  1 
ATOM   182  N N   . LEU A 1 24  ? 155.595 75.438  101.972 1 116.726 ? 462 LEU A N   1 
ATOM   183  C CA  . LEU A 1 24  ? 154.896 75.019  100.767 1 110.932 ? 462 LEU A CA  1 
ATOM   184  C C   . LEU A 1 24  ? 154.757 76.209  99.825  1 105.729 ? 462 LEU A C   1 
ATOM   185  O O   . LEU A 1 24  ? 154.878 77.36   100.24  1 117.182 ? 462 LEU A O   1 
ATOM   186  C CB  . LEU A 1 24  ? 153.527 74.465  101.133 1 103.703 ? 462 LEU A CB  1 
ATOM   187  C CG  . LEU A 1 24  ? 153.537 73.294  102.115 1 104.93  ? 462 LEU A CG  1 
ATOM   188  C CD1 . LEU A 1 24  ? 152.348 73.361  103.034 1 107.132 ? 462 LEU A CD1 1 
ATOM   189  C CD2 . LEU A 1 24  ? 153.544 71.981  101.352 1 119.162 ? 462 LEU A CD2 1 
ATOM   190  N N   . SER A 1 25  ? 154.497 75.909  98.551  1 107.654 ? 463 SER A N   1 
ATOM   191  C CA  . SER A 1 25  ? 154.29  76.946  97.553  1 117.466 ? 463 SER A CA  1 
ATOM   192  C C   . SER A 1 25  ? 152.799 77.051  97.223  1 119.377 ? 463 SER A C   1 
ATOM   193  O O   . SER A 1 25  ? 151.994 76.213  97.643  1 110.765 ? 463 SER A O   1 
ATOM   194  C CB  . SER A 1 25  ? 155.11  76.684  96.317  1 118.797 ? 463 SER A CB  1 
ATOM   195  O OG  . SER A 1 25  ? 154.415 75.827  95.42   1 110.345 ? 463 SER A OG  1 
ATOM   196  N N   . ASP A 1 26  ? 152.442 78.085  96.451  1 101.594 ? 464 ASP A N   1 
ATOM   197  C CA  . ASP A 1 26  ? 151.047 78.321  96.108  1 112.004 ? 464 ASP A CA  1 
ATOM   198  C C   . ASP A 1 26  ? 150.473 77.133  95.343  1 110.482 ? 464 ASP A C   1 
ATOM   199  O O   . ASP A 1 26  ? 149.366 76.69   95.648  1 102.661 ? 464 ASP A O   1 
ATOM   200  C CB  . ASP A 1 26  ? 150.877 79.605  95.32   1 113.288 ? 464 ASP A CB  1 
ATOM   201  C CG  . ASP A 1 26  ? 150.986 80.862  96.168  1 130.473 ? 464 ASP A CG  1 
ATOM   202  O OD1 . ASP A 1 26  ? 151.062 81.966  95.573  1 125.873 ? 464 ASP A OD1 1 
ATOM   203  O OD2 . ASP A 1 26  ? 150.992 80.72   97.418  1 114.404 ? 464 ASP A OD2 1 
ATOM   204  N N   . ALA A 1 27  ? 151.227 76.611  94.367  1 107.688 ? 465 ALA A N   1 
ATOM   205  C CA  . ALA A 1 27  ? 150.764 75.472  93.583  1 117.091 ? 465 ALA A CA  1 
ATOM   206  C C   . ALA A 1 27  ? 150.511 74.254  94.473  1 111.964 ? 465 ALA A C   1 
ATOM   207  O O   . ALA A 1 27  ? 149.579 73.49   94.222  1 118.081 ? 465 ALA A O   1 
ATOM   208  C CB  . ALA A 1 27  ? 151.764 75.142  92.495  1 113.617 ? 465 ALA A CB  1 
ATOM   209  N N   . GLU A 1 28  ? 151.336 74.081  95.51   1 104.182 ? 466 GLU A N   1 
ATOM   210  C CA  . GLU A 1 28  ? 151.198 72.951  96.419  1 112.158 ? 466 GLU A CA  1 
ATOM   211  C C   . GLU A 1 28  ? 149.9   73.063  97.216  1 111.212 ? 466 GLU A C   1 
ATOM   212  O O   . GLU A 1 28  ? 149.184 72.074  97.381  1 113.159 ? 466 GLU A O   1 
ATOM   213  C CB  . GLU A 1 28  ? 152.406 72.889  97.352  1 119.721 ? 466 GLU A CB  1 
ATOM   214  C CG  . GLU A 1 28  ? 153.731 73.068  96.611  1 131.613 ? 466 GLU A CG  1 
ATOM   215  C CD  . GLU A 1 28  ? 154.91  72.335  97.234  1 144.027 ? 466 GLU A CD  1 
ATOM   216  O OE1 . GLU A 1 28  ? 156.018 72.365  96.639  1 129.096 ? 466 GLU A OE1 1 
ATOM   217  O OE2 . GLU A 1 28  ? 154.713 71.731  98.314  1 134.671 ? 466 GLU A OE2 1 
ATOM   218  N N   . ILE A 1 29  ? 149.599 74.271  97.713  1 107.712 ? 467 ILE A N   1 
ATOM   219  C CA  . ILE A 1 29  ? 148.343 74.492  98.414  1 102.108 ? 467 ILE A CA  1 
ATOM   220  C C   . ILE A 1 29  ? 147.177 74.249  97.454  1 107.917 ? 467 ILE A C   1 
ATOM   221  O O   . ILE A 1 29  ? 146.16  73.672  97.838  1 104.565 ? 467 ILE A O   1 
ATOM   222  C CB  . ILE A 1 29  ? 148.272 75.904  99.01   1 103.919 ? 467 ILE A CB  1 
ATOM   223  C CG1 . ILE A 1 29  ? 149.515 76.25   99.831  1 106.802 ? 467 ILE A CG1 1 
ATOM   224  C CG2 . ILE A 1 29  ? 146.992 76.057  99.83   1 104.292 ? 467 ILE A CG2 1 
ATOM   225  C CD1 . ILE A 1 29  ? 149.694 75.383  101.058 1 103.505 ? 467 ILE A CD1 1 
ATOM   226  N N   . ILE A 1 30  ? 147.317 74.704  96.204  1 96.787  ? 468 ILE A N   1 
ATOM   227  C CA  . ILE A 1 30  ? 146.272 74.511  95.211  1 98.819  ? 468 ILE A CA  1 
ATOM   228  C C   . ILE A 1 30  ? 146.001 73.019  95.047  1 101.568 ? 468 ILE A C   1 
ATOM   229  O O   . ILE A 1 30  ? 144.846 72.595  95.006  1 103.701 ? 468 ILE A O   1 
ATOM   230  C CB  . ILE A 1 30  ? 146.664 75.187  93.886  1 103.057 ? 468 ILE A CB  1 
ATOM   231  C CG1 . ILE A 1 30  ? 146.328 76.674  93.918  1 100.926 ? 468 ILE A CG1 1 
ATOM   232  C CG2 . ILE A 1 30  ? 146.015 74.493  92.687  1 108.004 ? 468 ILE A CG2 1 
ATOM   233  C CD1 . ILE A 1 30  ? 147.209 77.514  93.008  1 105.84  ? 468 ILE A CD1 1 
ATOM   234  N N   . GLN A 1 31  ? 147.075 72.23   94.942  1 100.988 ? 469 GLN A N   1 
ATOM   235  C CA  . GLN A 1 31  ? 146.956 70.788  94.767  1 109.212 ? 469 GLN A CA  1 
ATOM   236  C C   . GLN A 1 31  ? 146.24  70.162  95.964  1 106.369 ? 469 GLN A C   1 
ATOM   237  O O   . GLN A 1 31  ? 145.33  69.345  95.8    1 108.531 ? 469 GLN A O   1 
ATOM   238  C CB  . GLN A 1 31  ? 148.35  70.187  94.591  1 114.416 ? 469 GLN A CB  1 
ATOM   239  C CG  . GLN A 1 31  ? 148.411 69.046  93.581  1 121.323 ? 469 GLN A CG  1 
ATOM   240  C CD  . GLN A 1 31  ? 149.816 68.831  93.058  1 127.996 ? 469 GLN A CD  1 
ATOM   241  O OE1 . GLN A 1 31  ? 150.777 68.738  93.835  1 103.625 ? 469 GLN A OE1 1 
ATOM   242  N NE2 . GLN A 1 31  ? 149.948 68.792  91.737  1 123.82  ? 469 GLN A NE2 1 
ATOM   243  N N   . LEU A 1 32  ? 146.639 70.569  97.174  1 99.977  ? 470 LEU A N   1 
ATOM   244  C CA  . LEU A 1 32  ? 146.029 70.027  98.377  1 109.277 ? 470 LEU A CA  1 
ATOM   245  C C   . LEU A 1 32  ? 144.545 70.382  98.44   1 116.275 ? 470 LEU A C   1 
ATOM   246  O O   . LEU A 1 32  ? 143.73  69.55   98.836  1 121.162 ? 470 LEU A O   1 
ATOM   247  C CB  . LEU A 1 32  ? 146.759 70.497  99.633  1 113.909 ? 470 LEU A CB  1 
ATOM   248  C CG  . LEU A 1 32  ? 148.051 69.748  99.971  1 119.86  ? 470 LEU A CG  1 
ATOM   249  C CD1 . LEU A 1 32  ? 148.618 70.253  101.295 1 121.691 ? 470 LEU A CD1 1 
ATOM   250  C CD2 . LEU A 1 32  ? 147.79  68.249  100.034 1 119.496 ? 470 LEU A CD2 1 
ATOM   251  N N   . VAL A 1 33  ? 144.181 71.604  98.044  1 109.577 ? 471 VAL A N   1 
ATOM   252  C CA  . VAL A 1 33  ? 142.778 71.989  98.064  1 108.732 ? 471 VAL A CA  1 
ATOM   253  C C   . VAL A 1 33  ? 142     71.162  97.038  1 109.471 ? 471 VAL A C   1 
ATOM   254  O O   . VAL A 1 33  ? 140.924 70.644  97.339  1 109.871 ? 471 VAL A O   1 
ATOM   255  C CB  . VAL A 1 33  ? 142.592 73.497  97.838  1 100.125 ? 471 VAL A CB  1 
ATOM   256  C CG1 . VAL A 1 33  ? 141.116 73.854  97.74   1 105.618 ? 471 VAL A CG1 1 
ATOM   257  C CG2 . VAL A 1 33  ? 143.252 74.319  98.941  1 98.285  ? 471 VAL A CG2 1 
ATOM   258  N N   . ASN A 1 34  ? 142.55  71.017  95.829  1 108.167 ? 472 ASN A N   1 
ATOM   259  C CA  . ASN A 1 34  ? 141.863 70.273  94.78   1 115.566 ? 472 ASN A CA  1 
ATOM   260  C C   . ASN A 1 34  ? 141.702 68.797  95.142  1 120.097 ? 472 ASN A C   1 
ATOM   261  O O   . ASN A 1 34  ? 140.807 68.141  94.614  1 132.882 ? 472 ASN A O   1 
ATOM   262  C CB  . ASN A 1 34  ? 142.577 70.401  93.441  1 116.108 ? 472 ASN A CB  1 
ATOM   263  C CG  . ASN A 1 34  ? 142.546 71.823  92.93   1 114.266 ? 472 ASN A CG  1 
ATOM   264  O OD1 . ASN A 1 34  ? 143.596 72.421  92.665  1 110.465 ? 472 ASN A OD1 1 
ATOM   265  N ND2 . ASN A 1 34  ? 141.353 72.38   92.788  1 114.446 ? 472 ASN A ND2 1 
ATOM   266  N N   . ALA A 1 35  ? 142.554 68.27   96.033  1 126.276 ? 473 ALA A N   1 
ATOM   267  C CA  . ALA A 1 35  ? 142.471 66.865  96.424  1 121.324 ? 473 ALA A CA  1 
ATOM   268  C C   . ALA A 1 35  ? 141.543 66.645  97.622  1 124.841 ? 473 ALA A C   1 
ATOM   269  O O   . ALA A 1 35  ? 141.381 65.506  98.065  1 129.593 ? 473 ALA A O   1 
ATOM   270  C CB  . ALA A 1 35  ? 143.857 66.329  96.727  1 117.545 ? 473 ALA A CB  1 
ATOM   271  N N   . LYS A 1 36  ? 140.949 67.722  98.156  1 118.509 ? 474 LYS A N   1 
ATOM   272  C CA  . LYS A 1 36  ? 140.037 67.641  99.291  1 109.682 ? 474 LYS A CA  1 
ATOM   273  C C   . LYS A 1 36  ? 140.784 67.472  100.616 1 116.602 ? 474 LYS A C   1 
ATOM   274  O O   . LYS A 1 36  ? 140.158 67.28   101.66  1 117.594 ? 474 LYS A O   1 
ATOM   275  C CB  . LYS A 1 36  ? 139.028 66.501  99.135  1 119.51  ? 474 LYS A CB  1 
ATOM   276  C CG  . LYS A 1 36  ? 138.337 66.43   97.776  1 123.324 ? 474 LYS A CG  1 
ATOM   277  C CD  . LYS A 1 36  ? 137.846 67.791  97.288  1 131.211 ? 474 LYS A CD  1 
ATOM   278  C CE  . LYS A 1 36  ? 136.591 67.666  96.469  1 142.728 ? 474 LYS A CE  1 
ATOM   279  N NZ  . LYS A 1 36  ? 136.706 66.707  95.361  1 145.33  ? 474 LYS A NZ  1 
ATOM   280  N N   . HIS A 1 37  ? 142.112 67.595  100.598 1 111.948 ? 475 HIS A N   1 
ATOM   281  C CA  . HIS A 1 37  ? 142.874 67.497  101.834 1 118.716 ? 475 HIS A CA  1 
ATOM   282  C C   . HIS A 1 37  ? 142.706 68.755  102.688 1 129.069 ? 475 HIS A C   1 
ATOM   283  O O   . HIS A 1 37  ? 142.953 68.719  103.893 1 131.784 ? 475 HIS A O   1 
ATOM   284  C CB  . HIS A 1 37  ? 144.347 67.233  101.525 1 118.685 ? 475 HIS A CB  1 
ATOM   285  C CG  . HIS A 1 37  ? 144.561 65.937  100.815 1 140.658 ? 475 HIS A CG  1 
ATOM   286  N ND1 . HIS A 1 37  ? 143.934 64.774  101.217 1 140.144 ? 475 HIS A ND1 1 
ATOM   287  C CD2 . HIS A 1 37  ? 145.312 65.613  99.748  1 143.314 ? 475 HIS A CD2 1 
ATOM   288  C CE1 . HIS A 1 37  ? 144.307 63.779  100.419 1 153.415 ? 475 HIS A CE1 1 
ATOM   289  N NE2 . HIS A 1 37  ? 145.141 64.264  99.516  1 151.388 ? 475 HIS A NE2 1 
ATOM   290  N N   . ILE A 1 38  ? 142.329 69.874  102.058 1 126.119 ? 476 ILE A N   1 
ATOM   291  C CA  . ILE A 1 38  ? 141.989 71.083  102.79  1 124.963 ? 476 ILE A CA  1 
ATOM   292  C C   . ILE A 1 38  ? 140.601 71.53   102.352 1 129.884 ? 476 ILE A C   1 
ATOM   293  O O   . ILE A 1 38  ? 140.245 71.404  101.182 1 134.234 ? 476 ILE A O   1 
ATOM   294  C CB  . ILE A 1 38  ? 143.025 72.188  102.536 1 123.329 ? 476 ILE A CB  1 
ATOM   295  C CG1 . ILE A 1 38  ? 144.438 71.728  102.906 1 124.738 ? 476 ILE A CG1 1 
ATOM   296  C CG2 . ILE A 1 38  ? 142.638 73.467  103.28  1 135.229 ? 476 ILE A CG2 1 
ATOM   297  C CD1 . ILE A 1 38  ? 145.532 72.494  102.182 1 121.003 ? 476 ILE A CD1 1 
ATOM   298  N N   . PRO A 1 39  ? 139.761 72.063  103.265 1 116.03  ? 477 PRO A N   1 
ATOM   299  C CA  . PRO A 1 39  ? 138.567 72.776  102.838 1 115.49  ? 477 PRO A CA  1 
ATOM   300  C C   . PRO A 1 39  ? 138.884 74.238  102.55  1 108.226 ? 477 PRO A C   1 
ATOM   301  O O   . PRO A 1 39  ? 139.474 74.912  103.395 1 110.329 ? 477 PRO A O   1 
ATOM   302  C CB  . PRO A 1 39  ? 137.613 72.577  104.004 1 115.046 ? 477 PRO A CB  1 
ATOM   303  C CG  . PRO A 1 39  ? 138.542 72.465  105.215 1 115.87  ? 477 PRO A CG  1 
ATOM   304  C CD  . PRO A 1 39  ? 139.89  71.981  104.729 1 116.145 ? 477 PRO A CD  1 
ATOM   305  N N   . ALA A 1 40  ? 138.489 74.718  101.363 1 104.945 ? 478 ALA A N   1 
ATOM   306  C CA  . ALA A 1 40  ? 138.848 76.063  100.923 1 102.755 ? 478 ALA A CA  1 
ATOM   307  C C   . ALA A 1 40  ? 138.341 77.126  101.894 1 102.833 ? 478 ALA A C   1 
ATOM   308  O O   . ALA A 1 40  ? 138.969 78.176  102.043 1 104.878 ? 478 ALA A O   1 
ATOM   309  C CB  . ALA A 1 40  ? 138.322 76.33   99.533  1 106.13  ? 478 ALA A CB  1 
ATOM   310  N N   . TYR A 1 41  ? 137.206 76.869  102.556 1 107.564 ? 479 TYR A N   1 
ATOM   311  C CA  . TYR A 1 41  ? 136.619 77.884  103.419 1 114.682 ? 479 TYR A CA  1 
ATOM   312  C C   . TYR A 1 41  ? 137.519 78.161  104.624 1 103.34  ? 479 TYR A C   1 
ATOM   313  O O   . TYR A 1 41  ? 137.37  79.193  105.279 1 114.489 ? 479 TYR A O   1 
ATOM   314  C CB  . TYR A 1 41  ? 135.215 77.477  103.873 1 122.687 ? 479 TYR A CB  1 
ATOM   315  C CG  . TYR A 1 41  ? 135.19  76.424  104.969 1 123.904 ? 479 TYR A CG  1 
ATOM   316  C CD1 . TYR A 1 41  ? 135.345 76.779  106.304 1 122.758 ? 479 TYR A CD1 1 
ATOM   317  C CD2 . TYR A 1 41  ? 134.99  75.083  104.664 1 128.14  ? 479 TYR A CD2 1 
ATOM   318  C CE1 . TYR A 1 41  ? 135.319 75.822  107.305 1 142.097 ? 479 TYR A CE1 1 
ATOM   319  C CE2 . TYR A 1 41  ? 134.95  74.117  105.657 1 126.761 ? 479 TYR A CE2 1 
ATOM   320  C CZ  . TYR A 1 41  ? 135.117 74.488  106.983 1 139.478 ? 479 TYR A CZ  1 
ATOM   321  O OH  . TYR A 1 41  ? 135.09  73.549  107.978 1 141.285 ? 479 TYR A OH  1 
ATOM   322  N N   . LYS A 1 42  ? 138.458 77.248  104.909 1 105.656 ? 480 LYS A N   1 
ATOM   323  C CA  . LYS A 1 42  ? 139.326 77.368  106.074 1 110.631 ? 480 LYS A CA  1 
ATOM   324  C C   . LYS A 1 42  ? 140.69  77.953  105.704 1 108.669 ? 480 LYS A C   1 
ATOM   325  O O   . LYS A 1 42  ? 141.551 78.058  106.571 1 107.732 ? 480 LYS A O   1 
ATOM   326  C CB  . LYS A 1 42  ? 139.52  75.966  106.665 1 122.238 ? 480 LYS A CB  1 
ATOM   327  C CG  . LYS A 1 42  ? 139.243 75.828  108.15  1 136.323 ? 480 LYS A CG  1 
ATOM   328  C CD  . LYS A 1 42  ? 139.379 74.375  108.603 1 134.067 ? 480 LYS A CD  1 
ATOM   329  C CE  . LYS A 1 42  ? 139.126 74.179  110.072 1 134.854 ? 480 LYS A CE  1 
ATOM   330  N NZ  . LYS A 1 42  ? 140.18  74.78   110.901 1 132.637 ? 480 LYS A NZ  1 
ATOM   331  N N   . LEU A 1 43  ? 140.89  78.342  104.439 1 99.29   ? 481 LEU A N   1 
ATOM   332  C CA  . LEU A 1 43  ? 142.209 78.713  103.946 1 99.122  ? 481 LEU A CA  1 
ATOM   333  C C   . LEU A 1 43  ? 142.818 79.875  104.727 1 100.767 ? 481 LEU A C   1 
ATOM   334  O O   . LEU A 1 43  ? 144.032 80.041  104.719 1 108.606 ? 481 LEU A O   1 
ATOM   335  C CB  . LEU A 1 43  ? 142.146 79.065  102.46  1 97.996  ? 481 LEU A CB  1 
ATOM   336  C CG  . LEU A 1 43  ? 142.25  77.887  101.489 1 109.168 ? 481 LEU A CG  1 
ATOM   337  C CD1 . LEU A 1 43  ? 141.919 78.316  100.066 1 110.967 ? 481 LEU A CD1 1 
ATOM   338  C CD2 . LEU A 1 43  ? 143.646 77.289  101.562 1 100.784 ? 481 LEU A CD2 1 
ATOM   339  N N   . GLU A 1 44  ? 141.995 80.714  105.355 1 99.672  ? 482 GLU A N   1 
ATOM   340  C CA  . GLU A 1 44  ? 142.514 81.906  106.014 1 101.438 ? 482 GLU A CA  1 
ATOM   341  C C   . GLU A 1 44  ? 143.076 81.58   107.401 1 111.125 ? 482 GLU A C   1 
ATOM   342  O O   . GLU A 1 44  ? 143.796 82.401  107.969 1 110.648 ? 482 GLU A O   1 
ATOM   343  C CB  . GLU A 1 44  ? 141.429 82.98   106.12  1 110.754 ? 482 GLU A CB  1 
ATOM   344  C CG  . GLU A 1 44  ? 140.535 83.056  104.883 1 119.669 ? 482 GLU A CG  1 
ATOM   345  C CD  . GLU A 1 44  ? 140.091 84.465  104.555 1 120.8   ? 482 GLU A CD  1 
ATOM   346  O OE1 . GLU A 1 44  ? 140.218 84.835  103.365 1 132.894 ? 482 GLU A OE1 1 
ATOM   347  O OE2 . GLU A 1 44  ? 139.652 85.205  105.477 1 123.517 ? 482 GLU A OE2 1 
ATOM   348  N N   . THR A 1 45  ? 142.736 80.411  107.965 1 107.102 ? 483 THR A N   1 
ATOM   349  C CA  . THR A 1 45  ? 143.27  80.005  109.263 1 115.684 ? 483 THR A CA  1 
ATOM   350  C C   . THR A 1 45  ? 144.438 79.031  109.087 1 123.322 ? 483 THR A C   1 
ATOM   351  O O   . THR A 1 45  ? 145.473 79.196  109.732 1 128.693 ? 483 THR A O   1 
ATOM   352  C CB  . THR A 1 45  ? 142.174 79.387  110.126 1 118.678 ? 483 THR A CB  1 
ATOM   353  O OG1 . THR A 1 45  ? 141.867 78.093  109.612 1 104.748 ? 483 THR A OG1 1 
ATOM   354  C CG2 . THR A 1 45  ? 140.925 80.25   110.148 1 136.452 ? 483 THR A CG2 1 
ATOM   355  N N   . LEU A 1 46  ? 144.267 78.012  108.232 1 113.171 ? 484 LEU A N   1 
ATOM   356  C CA  . LEU A 1 46  ? 145.3   77.01   108.001 1 114.048 ? 484 LEU A CA  1 
ATOM   357  C C   . LEU A 1 46  ? 146.368 77.533  107.044 1 108.918 ? 484 LEU A C   1 
ATOM   358  O O   . LEU A 1 46  ? 146.749 76.832  106.108 1 114.975 ? 484 LEU A O   1 
ATOM   359  C CB  . LEU A 1 46  ? 144.663 75.734  107.445 1 118.645 ? 484 LEU A CB  1 
ATOM   360  C CG  . LEU A 1 46  ? 144.168 74.719  108.479 1 124.821 ? 484 LEU A CG  1 
ATOM   361  C CD1 . LEU A 1 46  ? 143.476 75.385  109.661 1 119.162 ? 484 LEU A CD1 1 
ATOM   362  C CD2 . LEU A 1 46  ? 143.233 73.726  107.786 1 134.025 ? 484 LEU A CD2 1 
ATOM   363  N N   . MET A 1 47  ? 146.897 78.726  107.32  1 103.743 ? 485 MET A N   1 
ATOM   364  C CA  . MET A 1 47  ? 147.804 79.387  106.395 1 106.228 ? 485 MET A CA  1 
ATOM   365  C C   . MET A 1 47  ? 148.541 80.475  107.172 1 104.736 ? 485 MET A C   1 
ATOM   366  O O   . MET A 1 47  ? 147.987 81.05   108.109 1 113.078 ? 485 MET A O   1 
ATOM   367  C CB  . MET A 1 47  ? 147.004 79.989  105.236 1 110.26  ? 485 MET A CB  1 
ATOM   368  C CG  . MET A 1 47  ? 147.821 80.496  104.067 1 118.444 ? 485 MET A CG  1 
ATOM   369  S SD  . MET A 1 47  ? 148.424 79.232  102.928 1 111.134 ? 485 MET A SD  1 
ATOM   370  C CE  . MET A 1 47  ? 147.433 77.776  103.291 1 116.498 ? 485 MET A CE  1 
ATOM   371  N N   . GLU A 1 48  ? 149.8   80.721  106.806 1 103.553 ? 486 GLU A N   1 
ATOM   372  C CA  . GLU A 1 48  ? 150.691 81.525  107.632 1 112.968 ? 486 GLU A CA  1 
ATOM   373  C C   . GLU A 1 48  ? 150.042 82.865  107.982 1 108.532 ? 486 GLU A C   1 
ATOM   374  O O   . GLU A 1 48  ? 150.169 83.325  109.118 1 118.626 ? 486 GLU A O   1 
ATOM   375  C CB  . GLU A 1 48  ? 152.064 81.742  106.993 1 110.164 ? 486 GLU A CB  1 
ATOM   376  C CG  . GLU A 1 48  ? 152.019 82.128  105.518 1 110.021 ? 486 GLU A CG  1 
ATOM   377  C CD  . GLU A 1 48  ? 151.883 80.941  104.576 1 137.374 ? 486 GLU A CD  1 
ATOM   378  O OE1 . GLU A 1 48  ? 151.182 79.956  104.925 1 129.469 ? 486 GLU A OE1 1 
ATOM   379  O OE2 . GLU A 1 48  ? 152.495 81.013  103.485 1 140.81  ? 486 GLU A OE2 1 
ATOM   380  N N   . THR A 1 49  ? 149.365 83.488  107.004 1 103.503 ? 487 THR A N   1 
ATOM   381  C CA  . THR A 1 49  ? 148.619 84.72   107.246 1 107.795 ? 487 THR A CA  1 
ATOM   382  C C   . THR A 1 49  ? 147.262 84.661  106.545 1 98.705  ? 487 THR A C   1 
ATOM   383  O O   . THR A 1 49  ? 147.019 83.802  105.699 1 105.29  ? 487 THR A O   1 
ATOM   384  C CB  . THR A 1 49  ? 149.424 85.939  106.796 1 111.045 ? 487 THR A CB  1 
ATOM   385  O OG1 . THR A 1 49  ? 149.182 86.138  105.406 1 113.707 ? 487 THR A OG1 1 
ATOM   386  C CG2 . THR A 1 49  ? 150.908 85.773  107.071 1 120.328 ? 487 THR A CG2 1 
ATOM   387  N N   . HIS A 1 50  ? 146.373 85.591  106.909 1 101.012 ? 488 HIS A N   1 
ATOM   388  C CA  . HIS A 1 50  ? 145.029 85.626  106.349 1 88.385  ? 488 HIS A CA  1 
ATOM   389  C C   . HIS A 1 50  ? 145.063 86.096  104.896 1 79.336  ? 488 HIS A C   1 
ATOM   390  O O   . HIS A 1 50  ? 144.354 85.564  104.054 1 86.55   ? 488 HIS A O   1 
ATOM   391  C CB  . HIS A 1 50  ? 144.134 86.53   107.198 1 94.846  ? 488 HIS A CB  1 
ATOM   392  C CG  . HIS A 1 50  ? 144.159 86.179  108.647 1 107.401 ? 488 HIS A CG  1 
ATOM   393  N ND1 . HIS A 1 50  ? 144.017 84.89   109.117 1 109.962 ? 488 HIS A ND1 1 
ATOM   394  C CD2 . HIS A 1 50  ? 144.312 86.957  109.731 1 115.429 ? 488 HIS A CD2 1 
ATOM   395  C CE1 . HIS A 1 50  ? 144.084 84.898  110.445 1 117.106 ? 488 HIS A CE1 1 
ATOM   396  N NE2 . HIS A 1 50  ? 144.255 86.146  110.841 1 119.092 ? 488 HIS A NE2 1 
ATOM   397  N N   . GLU A 1 51  ? 145.907 87.088  104.611 1 86.322  ? 489 GLU A N   1 
ATOM   398  C CA  . GLU A 1 51  ? 146.044 87.624  103.267 1 82.738  ? 489 GLU A CA  1 
ATOM   399  C C   . GLU A 1 51  ? 146.406 86.504  102.293 1 96.192  ? 489 GLU A C   1 
ATOM   400  O O   . GLU A 1 51  ? 145.888 86.466  101.179 1 103.956 ? 489 GLU A O   1 
ATOM   401  C CB  . GLU A 1 51  ? 147.12  88.702  103.294 1 83.453  ? 489 GLU A CB  1 
ATOM   402  C CG  . GLU A 1 51  ? 147.253 89.508  102.009 1 86.449  ? 489 GLU A CG  1 
ATOM   403  C CD  . GLU A 1 51  ? 148.314 90.584  102.136 1 101.306 ? 489 GLU A CD  1 
ATOM   404  O OE1 . GLU A 1 51  ? 148.972 90.682  103.209 1 112.439 ? 489 GLU A OE1 1 
ATOM   405  O OE2 . GLU A 1 51  ? 148.497 91.334  101.158 1 103.798 ? 489 GLU A OE2 1 
ATOM   406  N N   . ARG A 1 52  ? 147.29  85.591  102.711 1 87.493  ? 490 ARG A N   1 
ATOM   407  C CA  . ARG A 1 52  ? 147.718 84.505  101.847 1 95.393  ? 490 ARG A CA  1 
ATOM   408  C C   . ARG A 1 52  ? 146.549 83.56   101.582 1 90.405  ? 490 ARG A C   1 
ATOM   409  O O   . ARG A 1 52  ? 146.437 83.002  100.495 1 92.857  ? 490 ARG A O   1 
ATOM   410  C CB  . ARG A 1 52  ? 148.906 83.781  102.489 1 102.147 ? 490 ARG A CB  1 
ATOM   411  C CG  . ARG A 1 52  ? 149.301 82.445  101.879 1 107.36  ? 490 ARG A CG  1 
ATOM   412  C CD  . ARG A 1 52  ? 150.656 82.469  101.225 1 114.926 ? 490 ARG A CD  1 
ATOM   413  N NE  . ARG A 1 52  ? 150.842 81.238  100.45  1 125.644 ? 490 ARG A NE  1 
ATOM   414  C CZ  . ARG A 1 52  ? 151.94  80.49   100.406 1 129.142 ? 490 ARG A CZ  1 
ATOM   415  N NH1 . ARG A 1 52  ? 153.025 80.828  101.09  1 128.271 ? 490 ARG A NH1 1 
ATOM   416  N NH2 . ARG A 1 52  ? 151.951 79.409  99.644  1 123.422 ? 490 ARG A NH2 1 
ATOM   417  N N   . GLY A 1 53  ? 145.681 83.369  102.575 1 91.001  ? 491 GLY A N   1 
ATOM   418  C CA  . GLY A 1 53  ? 144.508 82.533  102.378 1 86.263  ? 491 GLY A CA  1 
ATOM   419  C C   . GLY A 1 53  ? 143.58  83.1    101.301 1 87.256  ? 491 GLY A C   1 
ATOM   420  O O   . GLY A 1 53  ? 143.118 82.372  100.422 1 86.445  ? 491 GLY A O   1 
ATOM   421  N N   . VAL A 1 54  ? 143.331 84.405  101.357 1 76.108  ? 492 VAL A N   1 
ATOM   422  C CA  . VAL A 1 54  ? 142.479 85.03   100.358 1 90.048  ? 492 VAL A CA  1 
ATOM   423  C C   . VAL A 1 54  ? 143.175 84.996  98.996  1 90.989  ? 492 VAL A C   1 
ATOM   424  O O   . VAL A 1 54  ? 142.513 84.861  97.964  1 89.078  ? 492 VAL A O   1 
ATOM   425  C CB  . VAL A 1 54  ? 142.017 86.437  100.767 1 82.226  ? 492 VAL A CB  1 
ATOM   426  C CG1 . VAL A 1 54  ? 142.73  86.936  101.998 1 99.249  ? 492 VAL A CG1 1 
ATOM   427  C CG2 . VAL A 1 54  ? 142.128 87.445  99.638  1 80.663  ? 492 VAL A CG2 1 
ATOM   428  N N   . SER A 1 55  ? 144.504 85.101  98.988  1 86.258  ? 493 SER A N   1 
ATOM   429  C CA  . SER A 1 55  ? 145.273 84.94   97.755  1 85.383  ? 493 SER A CA  1 
ATOM   430  C C   . SER A 1 55  ? 145.041 83.559  97.131  1 76.537  ? 493 SER A C   1 
ATOM   431  O O   . SER A 1 55  ? 144.815 83.438  95.928  1 79.57   ? 493 SER A O   1 
ATOM   432  C CB  . SER A 1 55  ? 146.743 85.172  97.994  1 85.234  ? 493 SER A CB  1 
ATOM   433  O OG  . SER A 1 55  ? 147.383 85.547  96.782  1 89.824  ? 493 SER A OG  1 
ATOM   434  N N   . ILE A 1 56  ? 145.109 82.51   97.955  1 77.423  ? 494 ILE A N   1 
ATOM   435  C CA  . ILE A 1 56  ? 144.909 81.158  97.459  1 79.011  ? 494 ILE A CA  1 
ATOM   436  C C   . ILE A 1 56  ? 143.498 81.032  96.892  1 82.821  ? 494 ILE A C   1 
ATOM   437  O O   . ILE A 1 56  ? 143.302 80.455  95.824  1 85.148  ? 494 ILE A O   1 
ATOM   438  C CB  . ILE A 1 56  ? 145.164 80.118  98.564  1 91.486  ? 494 ILE A CB  1 
ATOM   439  C CG1 . ILE A 1 56  ? 146.612 80.145  99.058  1 97.373  ? 494 ILE A CG1 1 
ATOM   440  C CG2 . ILE A 1 56  ? 144.776 78.718  98.086  1 88.794  ? 494 ILE A CG2 1 
ATOM   441  C CD1 . ILE A 1 56  ? 147.633 80.152  97.939  1 98.562  ? 494 ILE A CD1 1 
ATOM   442  N N   . ARG A 1 57  ? 142.508 81.544  97.628  1 82.891  ? 495 ARG A N   1 
ATOM   443  C CA  . ARG A 1 57  ? 141.128 81.487  97.175  1 80.494  ? 495 ARG A CA  1 
ATOM   444  C C   . ARG A 1 57  ? 141.008 82.183  95.822  1 72.844  ? 495 ARG A C   1 
ATOM   445  O O   . ARG A 1 57  ? 140.321 81.677  94.932  1 74.19   ? 495 ARG A O   1 
ATOM   446  C CB  . ARG A 1 57  ? 140.18  82.111  98.213  1 86.644  ? 495 ARG A CB  1 
ATOM   447  C CG  . ARG A 1 57  ? 138.717 81.821  97.926  1 86.733  ? 495 ARG A CG  1 
ATOM   448  C CD  . ARG A 1 57  ? 137.761 82.368  98.971  1 93.148  ? 495 ARG A CD  1 
ATOM   449  N NE  . ARG A 1 57  ? 137.857 81.637  100.24  1 90.407  ? 495 ARG A NE  1 
ATOM   450  C CZ  . ARG A 1 57  ? 138.508 82.057  101.319 1 87.151  ? 495 ARG A CZ  1 
ATOM   451  N NH1 . ARG A 1 57  ? 139.098 83.245  101.35  1 80.323  ? 495 ARG A NH1 1 
ATOM   452  N NH2 . ARG A 1 57  ? 138.609 81.254  102.362 1 94.275  ? 495 ARG A NH2 1 
ATOM   453  N N   . ARG A 1 58  ? 141.662 83.346  95.681  1 74.049  ? 496 ARG A N   1 
ATOM   454  C CA  . ARG A 1 58  ? 141.612 84.094  94.436  1 74.775  ? 496 ARG A CA  1 
ATOM   455  C C   . ARG A 1 58  ? 142.182 83.272  93.279  1 81.113  ? 496 ARG A C   1 
ATOM   456  O O   . ARG A 1 58  ? 141.624 83.27   92.188  1 83.68   ? 496 ARG A O   1 
ATOM   457  C CB  . ARG A 1 58  ? 142.363 85.418  94.556  1 75.594  ? 496 ARG A CB  1 
ATOM   458  C CG  . ARG A 1 58  ? 141.64  86.462  95.396  1 77.494  ? 496 ARG A CG  1 
ATOM   459  C CD  . ARG A 1 58  ? 142.55  87.625  95.689  1 75.083  ? 496 ARG A CD  1 
ATOM   460  N NE  . ARG A 1 58  ? 142.994 88.256  94.442  1 69.229  ? 496 ARG A NE  1 
ATOM   461  C CZ  . ARG A 1 58  ? 142.539 89.407  93.961  1 71.863  ? 496 ARG A CZ  1 
ATOM   462  N NH1 . ARG A 1 58  ? 141.571 90.094  94.561  1 72.436  ? 496 ARG A NH1 1 
ATOM   463  N NH2 . ARG A 1 58  ? 143.03  89.885  92.838  1 68.217  ? 496 ARG A NH2 1 
ATOM   464  N N   . GLN A 1 59  ? 143.312 82.595  93.494  1 82.816  ? 497 GLN A N   1 
ATOM   465  C CA  . GLN A 1 59  ? 143.932 81.817  92.428  1 85.689  ? 497 GLN A CA  1 
ATOM   466  C C   . GLN A 1 59  ? 143.033 80.655  92.009  1 82.19   ? 497 GLN A C   1 
ATOM   467  O O   . GLN A 1 59  ? 142.824 80.425  90.811  1 87.967  ? 497 GLN A O   1 
ATOM   468  C CB  . GLN A 1 59  ? 145.311 81.332  92.853  1 83.481  ? 497 GLN A CB  1 
ATOM   469  C CG  . GLN A 1 59  ? 146.374 82.414  92.724  1 94.111  ? 497 GLN A CG  1 
ATOM   470  C CD  . GLN A 1 59  ? 147.568 82.145  93.609  1 102.626 ? 497 GLN A CD  1 
ATOM   471  O OE1 . GLN A 1 59  ? 148.294 81.161  93.433  1 108.415 ? 497 GLN A OE1 1 
ATOM   472  N NE2 . GLN A 1 59  ? 147.759 83.005  94.596  1 106.715 ? 497 GLN A NE2 1 
ATOM   473  N N   . LEU A 1 60  ? 142.458 79.968  93.004  1 78.776  ? 498 LEU A N   1 
ATOM   474  C CA  . LEU A 1 60  ? 141.516 78.899  92.722  1 80.839  ? 498 LEU A CA  1 
ATOM   475  C C   . LEU A 1 60  ? 140.357 79.427  91.877  1 86.35   ? 498 LEU A C   1 
ATOM   476  O O   . LEU A 1 60  ? 139.988 78.812  90.88   1 95.918  ? 498 LEU A O   1 
ATOM   477  C CB  . LEU A 1 60  ? 141.001 78.28   94.015  1 84.775  ? 498 LEU A CB  1 
ATOM   478  C CG  . LEU A 1 60  ? 142.003 77.469  94.834  1 90.619  ? 498 LEU A CG  1 
ATOM   479  C CD1 . LEU A 1 60  ? 141.316 76.795  96.003  1 93.27   ? 498 LEU A CD1 1 
ATOM   480  C CD2 . LEU A 1 60  ? 142.673 76.427  93.97   1 95.428  ? 498 LEU A CD2 1 
ATOM   481  N N   . LEU A 1 61  ? 139.779 80.559  92.289  1 83.339  ? 499 LEU A N   1 
ATOM   482  C CA  . LEU A 1 61  ? 138.641 81.125  91.587  1 83.576  ? 499 LEU A CA  1 
ATOM   483  C C   . LEU A 1 61  ? 139.056 81.477  90.163  1 80.568  ? 499 LEU A C   1 
ATOM   484  O O   . LEU A 1 61  ? 138.313 81.244  89.212  1 91.176  ? 499 LEU A O   1 
ATOM   485  C CB  . LEU A 1 61  ? 138.1   82.344  92.344  1 75.293  ? 499 LEU A CB  1 
ATOM   486  C CG  . LEU A 1 61  ? 137.006 83.145  91.63   1 82.841  ? 499 LEU A CG  1 
ATOM   487  C CD1 . LEU A 1 61  ? 135.817 82.259  91.328  1 83.013  ? 499 LEU A CD1 1 
ATOM   488  C CD2 . LEU A 1 61  ? 136.558 84.349  92.441  1 83.005  ? 499 LEU A CD2 1 
ATOM   489  N N   . SER A 1 62  ? 140.221 82.104  90.01   1 88.605  ? 500 SER A N   1 
ATOM   490  C CA  . SER A 1 62  ? 140.667 82.54   88.695  1 90.251  ? 500 SER A CA  1 
ATOM   491  C C   . SER A 1 62  ? 140.726 81.361  87.728  1 86.976  ? 500 SER A C   1 
ATOM   492  O O   . SER A 1 62  ? 140.375 81.49   86.558  1 101.803 ? 500 SER A O   1 
ATOM   493  C CB  . SER A 1 62  ? 141.984 83.235  88.776  1 88.51   ? 500 SER A CB  1 
ATOM   494  O OG  . SER A 1 62  ? 141.809 84.574  89.232  1 100.582 ? 500 SER A OG  1 
ATOM   495  N N   . LYS A 1 63  ? 141.166 80.203  88.207  1 86.07   ? 501 LYS A N   1 
ATOM   496  C CA  . LYS A 1 63  ? 141.277 79.056  87.327  1 93.343  ? 501 LYS A CA  1 
ATOM   497  C C   . LYS A 1 63  ? 139.917 78.694  86.711  1 98.611  ? 501 LYS A C   1 
ATOM   498  O O   . LYS A 1 63  ? 139.867 78.202  85.589  1 106.953 ? 501 LYS A O   1 
ATOM   499  C CB  . LYS A 1 63  ? 141.883 77.883  88.103  1 102.759 ? 501 LYS A CB  1 
ATOM   500  C CG  . LYS A 1 63  ? 142.62  76.85   87.26   1 116.588 ? 501 LYS A CG  1 
ATOM   501  C CD  . LYS A 1 63  ? 143.533 77.451  86.194  1 127.335 ? 501 LYS A CD  1 
ATOM   502  C CE  . LYS A 1 63  ? 144.507 76.44   85.631  1 140.098 ? 501 LYS A CE  1 
ATOM   503  N NZ  . LYS A 1 63  ? 143.825 75.245  85.117  1 133.3   ? 501 LYS A NZ  1 
ATOM   504  N N   . LYS A 1 64  ? 138.812 78.951  87.423  1 96.958  ? 502 LYS A N   1 
ATOM   505  C CA  . LYS A 1 64  ? 137.487 78.549  86.966  1 94.242  ? 502 LYS A CA  1 
ATOM   506  C C   . LYS A 1 64  ? 136.771 79.635  86.158  1 90.23   ? 502 LYS A C   1 
ATOM   507  O O   . LYS A 1 64  ? 135.635 79.43   85.742  1 100.914 ? 502 LYS A O   1 
ATOM   508  C CB  . LYS A 1 64  ? 136.585 78.193  88.153  1 91.964  ? 502 LYS A CB  1 
ATOM   509  C CG  . LYS A 1 64  ? 137.014 76.946  88.879  1 101.391 ? 502 LYS A CG  1 
ATOM   510  C CD  . LYS A 1 64  ? 136.15  76.598  90.081  1 104.6   ? 502 LYS A CD  1 
ATOM   511  C CE  . LYS A 1 64  ? 136.211 77.622  91.162  1 105.841 ? 502 LYS A CE  1 
ATOM   512  N NZ  . LYS A 1 64  ? 136.116 77.011  92.495  1 112.944 ? 502 LYS A NZ  1 
ATOM   513  N N   . LEU A 1 65  ? 137.408 80.782  85.923  1 88.553  ? 503 LEU A N   1 
ATOM   514  C CA  . LEU A 1 65  ? 136.745 81.865  85.211  1 86.511  ? 503 LEU A CA  1 
ATOM   515  C C   . LEU A 1 65  ? 137.045 81.764  83.72   1 92.862  ? 503 LEU A C   1 
ATOM   516  O O   . LEU A 1 65  ? 138.09  81.264  83.307  1 105.215 ? 503 LEU A O   1 
ATOM   517  C CB  . LEU A 1 65  ? 137.2   83.222  85.75   1 83.774  ? 503 LEU A CB  1 
ATOM   518  C CG  . LEU A 1 65  ? 136.755 83.557  87.177  1 89.876  ? 503 LEU A CG  1 
ATOM   519  C CD1 . LEU A 1 65  ? 137.504 84.778  87.67   1 90.821  ? 503 LEU A CD1 1 
ATOM   520  C CD2 . LEU A 1 65  ? 135.246 83.771  87.272  1 93.417  ? 503 LEU A CD2 1 
ATOM   521  N N   . SER A 1 66  ? 136.118 82.282  82.913  1 95.468  ? 504 SER A N   1 
ATOM   522  C CA  . SER A 1 66  ? 136.278 82.276  81.469  1 93.232  ? 504 SER A CA  1 
ATOM   523  C C   . SER A 1 66  ? 137.338 83.294  81.063  1 101.27  ? 504 SER A C   1 
ATOM   524  O O   . SER A 1 66  ? 137.962 83.161  80.01   1 107.132 ? 504 SER A O   1 
ATOM   525  C CB  . SER A 1 66  ? 134.979 82.554  80.756  1 102.369 ? 504 SER A CB  1 
ATOM   526  O OG  . SER A 1 66  ? 134.791 83.952  80.566  1 106.025 ? 504 SER A OG  1 
ATOM   527  N N   . GLU A 1 67  ? 137.517 84.328  81.891  1 101.098 ? 505 GLU A N   1 
ATOM   528  C CA  . GLU A 1 67  ? 138.593 85.284  81.692  1 102.497 ? 505 GLU A CA  1 
ATOM   529  C C   . GLU A 1 67  ? 139.469 85.262  82.938  1 95.768  ? 505 GLU A C   1 
ATOM   530  O O   . GLU A 1 67  ? 139.188 85.966  83.903  1 96.905  ? 505 GLU A O   1 
ATOM   531  C CB  . GLU A 1 67  ? 138.027 86.673  81.397  1 108.128 ? 505 GLU A CB  1 
ATOM   532  C CG  . GLU A 1 67  ? 139.094 87.75   81.224  1 116.675 ? 505 GLU A CG  1 
ATOM   533  C CD  . GLU A 1 67  ? 140.342 87.274  80.488  1 135.192 ? 505 GLU A CD  1 
ATOM   534  O OE1 . GLU A 1 67  ? 140.592 87.763  79.352  1 139.499 ? 505 GLU A OE1 1 
ATOM   535  O OE2 . GLU A 1 67  ? 141.078 86.432  81.062  1 110.443 ? 505 GLU A OE2 1 
ATOM   536  N N   . PRO A 1 68  ? 140.544 84.439  82.968  1 100.442 ? 506 PRO A N   1 
ATOM   537  C CA  . PRO A 1 68  ? 141.36  84.278  84.171  1 90.978  ? 506 PRO A CA  1 
ATOM   538  C C   . PRO A 1 68  ? 141.885 85.569  84.798  1 82.47   ? 506 PRO A C   1 
ATOM   539  O O   . PRO A 1 68  ? 142.246 85.582  85.973  1 91.648  ? 506 PRO A O   1 
ATOM   540  C CB  . PRO A 1 68  ? 142.529 83.424  83.691  1 100.314 ? 506 PRO A CB  1 
ATOM   541  C CG  . PRO A 1 68  ? 141.919 82.618  82.562  1 101.704 ? 506 PRO A CG  1 
ATOM   542  C CD  . PRO A 1 68  ? 140.991 83.569  81.868  1 98.592  ? 506 PRO A CD  1 
ATOM   543  N N   . SER A 1 69  ? 141.931 86.654  84.024  1 85.963  ? 507 SER A N   1 
ATOM   544  C CA  . SER A 1 69  ? 142.507 87.899  84.506  1 87.902  ? 507 SER A CA  1 
ATOM   545  C C   . SER A 1 69  ? 141.451 88.821  85.135  1 82.752  ? 507 SER A C   1 
ATOM   546  O O   . SER A 1 69  ? 141.737 89.989  85.388  1 85.388  ? 507 SER A O   1 
ATOM   547  C CB  . SER A 1 69  ? 143.223 88.589  83.369  1 92.065  ? 507 SER A CB  1 
ATOM   548  O OG  . SER A 1 69  ? 143.63  89.896  83.754  1 101.971 ? 507 SER A OG  1 
ATOM   549  N N   . SER A 1 70  ? 140.238 88.319  85.383  1 74.28   ? 508 SER A N   1 
ATOM   550  C CA  . SER A 1 70  ? 139.139 89.156  85.853  1 84.465  ? 508 SER A CA  1 
ATOM   551  C C   . SER A 1 70  ? 139.456 89.829  87.192  1 78.244  ? 508 SER A C   1 
ATOM   552  O O   . SER A 1 70  ? 139.145 91.008  87.366  1 81.535  ? 508 SER A O   1 
ATOM   553  C CB  . SER A 1 70  ? 137.863 88.365  85.959  1 83.254  ? 508 SER A CB  1 
ATOM   554  O OG  . SER A 1 70  ? 137.611 87.671  84.747  1 92.145  ? 508 SER A OG  1 
ATOM   555  N N   . LEU A 1 71  ? 140.103 89.098  88.115  1 71.444  ? 509 LEU A N   1 
ATOM   556  C CA  . LEU A 1 71  ? 140.351 89.61   89.453  1 76.571  ? 509 LEU A CA  1 
ATOM   557  C C   . LEU A 1 71  ? 141.498 90.614  89.519  1 78.615  ? 509 LEU A C   1 
ATOM   558  O O   . LEU A 1 71  ? 141.822 91.071  90.601  1 85.494  ? 509 LEU A O   1 
ATOM   559  C CB  . LEU A 1 71  ? 140.609 88.457  90.413  1 77.928  ? 509 LEU A CB  1 
ATOM   560  C CG  . LEU A 1 71  ? 139.482 87.429  90.514  1 79.283  ? 509 LEU A CG  1 
ATOM   561  C CD1 . LEU A 1 71  ? 139.746 86.473  91.654  1 88.303  ? 509 LEU A CD1 1 
ATOM   562  C CD2 . LEU A 1 71  ? 138.159 88.129  90.676  1 86.034  ? 509 LEU A CD2 1 
ATOM   563  N N   . GLN A 1 72  ? 142.121 90.976  88.402  1 85.225  ? 510 GLN A N   1 
ATOM   564  C CA  . GLN A 1 72  ? 143.379 91.708  88.471  1 82.895  ? 510 GLN A CA  1 
ATOM   565  C C   . GLN A 1 72  ? 143.216 93.014  89.248  1 79.047  ? 510 GLN A C   1 
ATOM   566  O O   . GLN A 1 72  ? 144.067 93.364  90.058  1 88.447  ? 510 GLN A O   1 
ATOM   567  C CB  . GLN A 1 72  ? 143.873 91.955  87.052  1 86.239  ? 510 GLN A CB  1 
ATOM   568  C CG  . GLN A 1 72  ? 145.073 92.883  86.946  1 107.249 ? 510 GLN A CG  1 
ATOM   569  C CD  . GLN A 1 72  ? 145.41  93.192  85.502  1 118.149 ? 510 GLN A CD  1 
ATOM   570  O OE1 . GLN A 1 72  ? 144.93  92.529  84.574  1 108.98  ? 510 GLN A OE1 1 
ATOM   571  N NE2 . GLN A 1 72  ? 146.211 94.228  85.294  1 130.878 ? 510 GLN A NE2 1 
ATOM   572  N N   . TYR A 1 73  ? 142.133 93.743  88.988  1 75.367  ? 511 TYR A N   1 
ATOM   573  C CA  . TYR A 1 73  ? 141.923 95.047  89.589  1 71.504  ? 511 TYR A CA  1 
ATOM   574  C C   . TYR A 1 73  ? 140.978 94.991  90.79   1 69.275  ? 511 TYR A C   1 
ATOM   575  O O   . TYR A 1 73  ? 140.605 96.042  91.309  1 80.304  ? 511 TYR A O   1 
ATOM   576  C CB  . TYR A 1 73  ? 141.397 96.029  88.545  1 74.985  ? 511 TYR A CB  1 
ATOM   577  C CG  . TYR A 1 73  ? 142.422 96.4    87.491  1 91.345  ? 511 TYR A CG  1 
ATOM   578  C CD1 . TYR A 1 73  ? 143.519 97.197  87.814  1 102.819 ? 511 TYR A CD1 1 
ATOM   579  C CD2 . TYR A 1 73  ? 142.286 95.972  86.175  1 92.777  ? 511 TYR A CD2 1 
ATOM   580  C CE1 . TYR A 1 73  ? 144.459 97.548  86.857  1 102.265 ? 511 TYR A CE1 1 
ATOM   581  C CE2 . TYR A 1 73  ? 143.212 96.326  85.207  1 101.216 ? 511 TYR A CE2 1 
ATOM   582  C CZ  . TYR A 1 73  ? 144.304 97.108  85.55   1 110.978 ? 511 TYR A CZ  1 
ATOM   583  O OH  . TYR A 1 73  ? 145.212 97.428  84.58   1 120.207 ? 511 TYR A OH  1 
ATOM   584  N N   . LEU A 1 74  ? 140.634 93.796  91.274  1 68.083  ? 512 LEU A N   1 
ATOM   585  C CA  . LEU A 1 74  ? 139.948 93.669  92.55   1 71.663  ? 512 LEU A CA  1 
ATOM   586  C C   . LEU A 1 74  ? 140.989 93.691  93.664  1 70.478  ? 512 LEU A C   1 
ATOM   587  O O   . LEU A 1 74  ? 141.72  92.722  93.821  1 82.183  ? 512 LEU A O   1 
ATOM   588  C CB  . LEU A 1 74  ? 139.134 92.375  92.596  1 71.256  ? 512 LEU A CB  1 
ATOM   589  C CG  . LEU A 1 74  ? 138.313 92.152  93.875  1 75.613  ? 512 LEU A CG  1 
ATOM   590  C CD1 . LEU A 1 74  ? 137.218 93.174  94.006  1 76.409  ? 512 LEU A CD1 1 
ATOM   591  C CD2 . LEU A 1 74  ? 137.734 90.763  93.951  1 78.854  ? 512 LEU A CD2 1 
ATOM   592  N N   . PRO A 1 75  ? 141.082 94.749  94.496  1 69.567  ? 513 PRO A N   1 
ATOM   593  C CA  . PRO A 1 75  ? 142.14  94.826  95.49   1 66.212  ? 513 PRO A CA  1 
ATOM   594  C C   . PRO A 1 75  ? 141.915 93.87   96.652  1 72.935  ? 513 PRO A C   1 
ATOM   595  O O   . PRO A 1 75  ? 140.78  93.691  97.091  1 91.312  ? 513 PRO A O   1 
ATOM   596  C CB  . PRO A 1 75  ? 142.091 96.263  95.965  1 73.898  ? 513 PRO A CB  1 
ATOM   597  C CG  . PRO A 1 75  ? 140.976 96.937  95.198  1 79.911  ? 513 PRO A CG  1 
ATOM   598  C CD  . PRO A 1 75  ? 140.134 95.863  94.606  1 70.683  ? 513 PRO A CD  1 
ATOM   599  N N   . TYR A 1 76  ? 142.983 93.26   97.16   1 80.128  ? 514 TYR A N   1 
ATOM   600  C CA  . TYR A 1 76  ? 142.849 92.402  98.325  1 81.352  ? 514 TYR A CA  1 
ATOM   601  C C   . TYR A 1 76  ? 143.968 92.556  99.351  1 78.925  ? 514 TYR A C   1 
ATOM   602  O O   . TYR A 1 76  ? 143.824 92.066  100.468 1 82.066  ? 514 TYR A O   1 
ATOM   603  C CB  . TYR A 1 76  ? 142.772 90.949  97.879  1 82.837  ? 514 TYR A CB  1 
ATOM   604  C CG  . TYR A 1 76  ? 144.087 90.369  97.401  1 90.556  ? 514 TYR A CG  1 
ATOM   605  C CD1 . TYR A 1 76  ? 144.604 90.689  96.153  1 90.727  ? 514 TYR A CD1 1 
ATOM   606  C CD2 . TYR A 1 76  ? 144.794 89.484  98.203  1 92.727  ? 514 TYR A CD2 1 
ATOM   607  C CE1 . TYR A 1 76  ? 145.802 90.15   95.717  1 92.804  ? 514 TYR A CE1 1 
ATOM   608  C CE2 . TYR A 1 76  ? 145.993 88.94   97.777  1 91.625  ? 514 TYR A CE2 1 
ATOM   609  C CZ  . TYR A 1 76  ? 146.494 89.272  96.532  1 87.085  ? 514 TYR A CZ  1 
ATOM   610  O OH  . TYR A 1 76  ? 147.683 88.737  96.132  1 103.914 ? 514 TYR A OH  1 
ATOM   611  N N   . ARG A 1 77  ? 145.063 93.241  99.015  1 85.016  ? 515 ARG A N   1 
ATOM   612  C CA  . ARG A 1 77  ? 146.235 93.262  99.887  1 88.81   ? 515 ARG A CA  1 
ATOM   613  C C   . ARG A 1 77  ? 146.195 94.446  100.853 1 86.538  ? 515 ARG A C   1 
ATOM   614  O O   . ARG A 1 77  ? 145.57  95.466  100.575 1 89.667  ? 515 ARG A O   1 
ATOM   615  C CB  . ARG A 1 77  ? 147.509 93.29   99.034  1 83.602  ? 515 ARG A CB  1 
ATOM   616  C CG  . ARG A 1 77  ? 147.727 91.952  98.329  1 99.101  ? 515 ARG A CG  1 
ATOM   617  C CD  . ARG A 1 77  ? 148.562 92.07   97.075  1 99.235  ? 515 ARG A CD  1 
ATOM   618  N NE  . ARG A 1 77  ? 149.655 93.036  97.167  1 105.806 ? 515 ARG A NE  1 
ATOM   619  C CZ  . ARG A 1 77  ? 150.275 93.552  96.105  1 136.86  ? 515 ARG A CZ  1 
ATOM   620  N NH1 . ARG A 1 77  ? 149.954 93.15   94.882  1 134.992 ? 515 ARG A NH1 1 
ATOM   621  N NH2 . ARG A 1 77  ? 151.224 94.466  96.269  1 141.991 ? 515 ARG A NH2 1 
ATOM   622  N N   . ASP A 1 78  ? 146.886 94.286  101.989 1 90.364  ? 516 ASP A N   1 
ATOM   623  C CA  . ASP A 1 78  ? 147.027 95.327  103.002 1 96.699  ? 516 ASP A CA  1 
ATOM   624  C C   . ASP A 1 78  ? 145.67  95.693  103.602 1 92.11   ? 516 ASP A C   1 
ATOM   625  O O   . ASP A 1 78  ? 145.383 96.861  103.858 1 112.371 ? 516 ASP A O   1 
ATOM   626  C CB  . ASP A 1 78  ? 147.725 96.559  102.453 1 98.064  ? 516 ASP A CB  1 
ATOM   627  C CG  . ASP A 1 78  ? 149.1   96.288  101.858 1 124.299 ? 516 ASP A CG  1 
ATOM   628  O OD1 . ASP A 1 78  ? 149.615 95.161  102.071 1 123.022 ? 516 ASP A OD1 1 
ATOM   629  O OD2 . ASP A 1 78  ? 149.641 97.199  101.176 1 129.186 ? 516 ASP A OD2 1 
ATOM   630  N N   . TYR A 1 79  ? 144.84  94.677  103.82  1 83.862  ? 517 TYR A N   1 
ATOM   631  C CA  . TYR A 1 79  ? 143.529 94.847  104.417 1 74.565  ? 517 TYR A CA  1 
ATOM   632  C C   . TYR A 1 79  ? 143.462 93.905  105.608 1 79.007  ? 517 TYR A C   1 
ATOM   633  O O   . TYR A 1 79  ? 144.011 92.807  105.561 1 91.007  ? 517 TYR A O   1 
ATOM   634  C CB  . TYR A 1 79  ? 142.397 94.525  103.438 1 82.449  ? 517 TYR A CB  1 
ATOM   635  C CG  . TYR A 1 79  ? 141.015 94.726  104.04  1 77.663  ? 517 TYR A CG  1 
ATOM   636  C CD1 . TYR A 1 79  ? 140.452 95.985  104.082 1 75.694  ? 517 TYR A CD1 1 
ATOM   637  C CD2 . TYR A 1 79  ? 140.303 93.668  104.599 1 85.872  ? 517 TYR A CD2 1 
ATOM   638  C CE1 . TYR A 1 79  ? 139.229 96.206  104.681 1 79.295  ? 517 TYR A CE1 1 
ATOM   639  C CE2 . TYR A 1 79  ? 139.062 93.867  105.173 1 87.508  ? 517 TYR A CE2 1 
ATOM   640  C CZ  . TYR A 1 79  ? 138.521 95.143  105.209 1 88.079  ? 517 TYR A CZ  1 
ATOM   641  O OH  . TYR A 1 79  ? 137.312 95.404  105.783 1 90.091  ? 517 TYR A OH  1 
ATOM   642  N N   . ASN A 1 80  ? 142.813 94.356  106.682 1 82.053  ? 518 ASN A N   1 
ATOM   643  C CA  . ASN A 1 80  ? 142.749 93.565  107.898 1 85.36   ? 518 ASN A CA  1 
ATOM   644  C C   . ASN A 1 80  ? 141.592 92.58   107.797 1 77.645  ? 518 ASN A C   1 
ATOM   645  O O   . ASN A 1 80  ? 140.45  92.953  108.047 1 94.263  ? 518 ASN A O   1 
ATOM   646  C CB  . ASN A 1 80  ? 142.591 94.459  109.123 1 93.109  ? 518 ASN A CB  1 
ATOM   647  C CG  . ASN A 1 80  ? 142.827 93.686  110.392 1 101.554 ? 518 ASN A CG  1 
ATOM   648  O OD1 . ASN A 1 80  ? 141.887 93.457  111.161 1 116.11  ? 518 ASN A OD1 1 
ATOM   649  N ND2 . ASN A 1 80  ? 144.061 93.244  110.606 1 127.682 ? 518 ASN A ND2 1 
ATOM   650  N N   . TYR A 1 81  ? 141.896 91.332  107.454 1 78.827  ? 519 TYR A N   1 
ATOM   651  C CA  . TYR A 1 81  ? 140.877 90.312  107.31  1 81.133  ? 519 TYR A CA  1 
ATOM   652  C C   . TYR A 1 81  ? 140.528 89.666  108.646 1 86.612  ? 519 TYR A C   1 
ATOM   653  O O   . TYR A 1 81  ? 139.525 88.968  108.725 1 93.272  ? 519 TYR A O   1 
ATOM   654  C CB  . TYR A 1 81  ? 141.312 89.205  106.345 1 77.261  ? 519 TYR A CB  1 
ATOM   655  C CG  . TYR A 1 81  ? 141.422 89.72   104.926 1 81.371  ? 519 TYR A CG  1 
ATOM   656  C CD1 . TYR A 1 81  ? 140.278 89.94   104.168 1 77.237  ? 519 TYR A CD1 1 
ATOM   657  C CD2 . TYR A 1 81  ? 142.659 90.001  104.359 1 79.256  ? 519 TYR A CD2 1 
ATOM   658  C CE1 . TYR A 1 81  ? 140.361 90.424  102.875 1 82.692  ? 519 TYR A CE1 1 
ATOM   659  C CE2 . TYR A 1 81  ? 142.753 90.492  103.07  1 82.453  ? 519 TYR A CE2 1 
ATOM   660  C CZ  . TYR A 1 81  ? 141.6   90.707  102.33  1 78.157  ? 519 TYR A CZ  1 
ATOM   661  O OH  . TYR A 1 81  ? 141.672 91.187  101.064 1 77.185  ? 519 TYR A OH  1 
ATOM   662  N N   . SER A 1 82  ? 141.341 89.865  109.683 1 86.179  ? 520 SER A N   1 
ATOM   663  C CA  . SER A 1 82  ? 141.086 89.231  110.971 1 87.382  ? 520 SER A CA  1 
ATOM   664  C C   . SER A 1 82  ? 139.725 89.645  111.531 1 90.373  ? 520 SER A C   1 
ATOM   665  O O   . SER A 1 82  ? 139.072 88.849  112.197 1 100.139 ? 520 SER A O   1 
ATOM   666  C CB  . SER A 1 82  ? 142.171 89.551  111.96  1 88.3    ? 520 SER A CB  1 
ATOM   667  O OG  . SER A 1 82  ? 142.017 90.868  112.466 1 96.325  ? 520 SER A OG  1 
ATOM   668  N N   . LEU A 1 83  ? 139.302 90.886  111.261 1 81.205  ? 521 LEU A N   1 
ATOM   669  C CA  . LEU A 1 83  ? 138.034 91.378  111.778 1 86.9    ? 521 LEU A CA  1 
ATOM   670  C C   . LEU A 1 83  ? 136.847 90.922  110.933 1 88.765  ? 521 LEU A C   1 
ATOM   671  O O   . LEU A 1 83  ? 135.717 91.098  111.361 1 96.256  ? 521 LEU A O   1 
ATOM   672  C CB  . LEU A 1 83  ? 138.049 92.899  111.883 1 89.826  ? 521 LEU A CB  1 
ATOM   673  C CG  . LEU A 1 83  ? 138.812 93.488  113.075 1 89.986  ? 521 LEU A CG  1 
ATOM   674  C CD1 . LEU A 1 83  ? 138.587 94.983  113.167 1 93.107  ? 521 LEU A CD1 1 
ATOM   675  C CD2 . LEU A 1 83  ? 138.395 92.827  114.374 1 93.815  ? 521 LEU A CD2 1 
ATOM   676  N N   . VAL A 1 84  ? 137.089 90.366  109.741 1 88.923  ? 522 VAL A N   1 
ATOM   677  C CA  . VAL A 1 84  ? 136.011 89.983  108.842 1 83.533  ? 522 VAL A CA  1 
ATOM   678  C C   . VAL A 1 84  ? 135.692 88.499  108.986 1 87.28   ? 522 VAL A C   1 
ATOM   679  O O   . VAL A 1 84  ? 134.541 88.088  108.838 1 86.086  ? 522 VAL A O   1 
ATOM   680  C CB  . VAL A 1 84  ? 136.366 90.347  107.386 1 86.192  ? 522 VAL A CB  1 
ATOM   681  C CG1 . VAL A 1 84  ? 135.402 89.716  106.391 1 90.26   ? 522 VAL A CG1 1 
ATOM   682  C CG2 . VAL A 1 84  ? 136.397 91.858  107.208 1 82.992  ? 522 VAL A CG2 1 
ATOM   683  N N   . MET A 1 85  ? 136.723 87.692  109.24  1 88.448  ? 523 MET A N   1 
ATOM   684  C CA  . MET A 1 85  ? 136.551 86.258  109.371 1 87.139  ? 523 MET A CA  1 
ATOM   685  C C   . MET A 1 85  ? 135.61  85.918  110.52  1 88.717  ? 523 MET A C   1 
ATOM   686  O O   . MET A 1 85  ? 135.708 86.466  111.617 1 92.592  ? 523 MET A O   1 
ATOM   687  C CB  . MET A 1 85  ? 137.898 85.595  109.641 1 99.225  ? 523 MET A CB  1 
ATOM   688  C CG  . MET A 1 85  ? 138.746 85.506  108.394 1 107.863 ? 523 MET A CG  1 
ATOM   689  S SD  . MET A 1 85  ? 140.217 84.523  108.731 1 127.774 ? 523 MET A SD  1 
ATOM   690  C CE  . MET A 1 85  ? 141.047 85.766  109.727 1 112.203 ? 523 MET A CE  1 
ATOM   691  N N   . GLY A 1 86  ? 134.679 85.008  110.247 1 87.815  ? 524 GLY A N   1 
ATOM   692  C CA  . GLY A 1 86  ? 133.784 84.527  111.282 1 92.483  ? 524 GLY A CA  1 
ATOM   693  C C   . GLY A 1 86  ? 132.846 85.623  111.792 1 96.868  ? 524 GLY A C   1 
ATOM   694  O O   . GLY A 1 86  ? 132.144 85.396  112.775 1 112.877 ? 524 GLY A O   1 
ATOM   695  N N   . ALA A 1 87  ? 132.804 86.783  111.122 1 89.83   ? 525 ALA A N   1 
ATOM   696  C CA  . ALA A 1 87  ? 131.959 87.87   111.597 1 97.703  ? 525 ALA A CA  1 
ATOM   697  C C   . ALA A 1 87  ? 131.145 88.507  110.47  1 90.991  ? 525 ALA A C   1 
ATOM   698  O O   . ALA A 1 87  ? 129.972 88.811  110.661 1 105.6   ? 525 ALA A O   1 
ATOM   699  C CB  . ALA A 1 87  ? 132.793 88.923  112.293 1 90.277  ? 525 ALA A CB  1 
ATOM   700  N N   . CYS A 1 88  ? 131.776 88.767  109.324 1 90.946  ? 526 CYS A N   1 
ATOM   701  C CA  . CYS A 1 88  ? 131.25  89.743  108.378 1 87.314  ? 526 CYS A CA  1 
ATOM   702  C C   . CYS A 1 88  ? 131.111 89.204  106.957 1 86.112  ? 526 CYS A C   1 
ATOM   703  O O   . CYS A 1 88  ? 130.233 89.663  106.234 1 85.792  ? 526 CYS A O   1 
ATOM   704  C CB  . CYS A 1 88  ? 132.112 90.993  108.332 1 89.789  ? 526 CYS A CB  1 
ATOM   705  S SG  . CYS A 1 88  ? 131.726 92.129  109.694 1 101.923 ? 526 CYS A SG  1 
ATOM   706  N N   . CYS A 1 89  ? 131.986 88.28   106.541 1 89.011  ? 527 CYS A N   1 
ATOM   707  C CA  . CYS A 1 89  ? 131.898 87.752  105.191 1 81.16   ? 527 CYS A CA  1 
ATOM   708  C C   . CYS A 1 89  ? 132.562 86.384  105.143 1 78.761  ? 527 CYS A C   1 
ATOM   709  O O   . CYS A 1 89  ? 133.396 86.066  105.986 1 93.271  ? 527 CYS A O   1 
ATOM   710  C CB  . CYS A 1 89  ? 132.516 88.744  104.213 1 87.239  ? 527 CYS A CB  1 
ATOM   711  S SG  . CYS A 1 89  ? 132.005 88.527  102.484 1 79.477  ? 527 CYS A SG  1 
ATOM   712  N N   . GLU A 1 90  ? 132.187 85.591  104.137 1 78.429  ? 528 GLU A N   1 
ATOM   713  C CA  . GLU A 1 90  ? 132.765 84.274  103.92  1 74.176  ? 528 GLU A CA  1 
ATOM   714  C C   . GLU A 1 90  ? 133.232 84.161  102.468 1 70.49   ? 528 GLU A C   1 
ATOM   715  O O   . GLU A 1 90  ? 132.799 84.949  101.622 1 74.059  ? 528 GLU A O   1 
ATOM   716  C CB  . GLU A 1 90  ? 131.763 83.152  104.198 1 80.374  ? 528 GLU A CB  1 
ATOM   717  C CG  . GLU A 1 90  ? 131.113 83.21   105.577 1 87.258  ? 528 GLU A CG  1 
ATOM   718  C CD  . GLU A 1 90  ? 129.975 84.212  105.717 1 95.675  ? 528 GLU A CD  1 
ATOM   719  O OE1 . GLU A 1 90  ? 129.065 84.239  104.857 1 85.365  ? 528 GLU A OE1 1 
ATOM   720  O OE2 . GLU A 1 90  ? 129.999 84.983  106.706 1 96.362  ? 528 GLU A OE2 1 
ATOM   721  N N   . ASN A 1 91  ? 134.102 83.171  102.199 1 75.638  ? 529 ASN A N   1 
ATOM   722  C CA  . ASN A 1 91  ? 134.732 82.977  100.905 1 68.384  ? 529 ASN A CA  1 
ATOM   723  C C   . ASN A 1 91  ? 135.274 84.298  100.357 1 64.754  ? 529 ASN A C   1 
ATOM   724  O O   . ASN A 1 91  ? 135.008 84.657  99.209  1 76.479  ? 529 ASN A O   1 
ATOM   725  C CB  . ASN A 1 91  ? 133.733 82.423  99.899  1 80.706  ? 529 ASN A CB  1 
ATOM   726  C CG  . ASN A 1 91  ? 133.078 81.151  100.374 1 90.167  ? 529 ASN A CG  1 
ATOM   727  O OD1 . ASN A 1 91  ? 131.857 81.017  100.272 1 95.338  ? 529 ASN A OD1 1 
ATOM   728  N ND2 . ASN A 1 91  ? 133.862 80.191  100.845 1 106.752 ? 529 ASN A ND2 1 
ATOM   729  N N   . VAL A 1 92  ? 136.055 84.997  101.168 1 62.761  ? 530 VAL A N   1 
ATOM   730  C CA  . VAL A 1 92  ? 136.504 86.332  100.824 1 74.316  ? 530 VAL A CA  1 
ATOM   731  C C   . VAL A 1 92  ? 137.585 86.279  99.747  1 72.653  ? 530 VAL A C   1 
ATOM   732  O O   . VAL A 1 92  ? 138.515 85.479  99.825  1 77.314  ? 530 VAL A O   1 
ATOM   733  C CB  . VAL A 1 92  ? 137.009 87.043  102.09  1 67.294  ? 530 VAL A CB  1 
ATOM   734  C CG1 . VAL A 1 92  ? 137.66  88.372  101.763 1 72.522  ? 530 VAL A CG1 1 
ATOM   735  C CG2 . VAL A 1 92  ? 135.869 87.258  103.055 1 71.237  ? 530 VAL A CG2 1 
ATOM   736  N N   . ILE A 1 93  ? 137.461 87.17   98.764  1 65.95   ? 531 ILE A N   1 
ATOM   737  C CA  . ILE A 1 93  ? 138.405 87.224  97.656  1 74.88   ? 531 ILE A CA  1 
ATOM   738  C C   . ILE A 1 93  ? 138.904 88.647  97.459  1 63.484  ? 531 ILE A C   1 
ATOM   739  O O   . ILE A 1 93  ? 139.51  88.937  96.445  1 65.356  ? 531 ILE A O   1 
ATOM   740  C CB  . ILE A 1 93  ? 137.774 86.693  96.361  1 70.263  ? 531 ILE A CB  1 
ATOM   741  C CG1 . ILE A 1 93  ? 136.626 87.597  95.929  1 77.134  ? 531 ILE A CG1 1 
ATOM   742  C CG2 . ILE A 1 93  ? 137.321 85.246  96.543  1 78.063  ? 531 ILE A CG2 1 
ATOM   743  C CD1 . ILE A 1 93  ? 136.491 87.737  94.435  1 82.991  ? 531 ILE A CD1 1 
ATOM   744  N N   . GLY A 1 94  ? 138.681 89.515  98.445  1 64.811  ? 532 GLY A N   1 
ATOM   745  C CA  . GLY A 1 94  ? 139.141 90.883  98.38   1 60.689  ? 532 GLY A CA  1 
ATOM   746  C C   . GLY A 1 94  ? 138.102 91.821  98.974  1 66.965  ? 532 GLY A C   1 
ATOM   747  O O   . GLY A 1 94  ? 137.26  91.399  99.761  1 70.927  ? 532 GLY A O   1 
ATOM   748  N N   . TYR A 1 95  ? 138.174 93.091  98.58   1 60.608  ? 533 TYR A N   1 
ATOM   749  C CA  . TYR A 1 95  ? 137.23  94.082  99.041  1 65.301  ? 533 TYR A CA  1 
ATOM   750  C C   . TYR A 1 95  ? 136.89  95.045  97.911  1 63.145  ? 533 TYR A C   1 
ATOM   751  O O   . TYR A 1 95  ? 137.675 95.251  97.018  1 63.142  ? 533 TYR A O   1 
ATOM   752  C CB  . TYR A 1 95  ? 137.799 94.852  100.237 1 70.248  ? 533 TYR A CB  1 
ATOM   753  C CG  . TYR A 1 95  ? 139.139 95.504  99.969  1 68.38   ? 533 TYR A CG  1 
ATOM   754  C CD1 . TYR A 1 95  ? 140.32  94.789  100.159 1 75.369  ? 533 TYR A CD1 1 
ATOM   755  C CD2 . TYR A 1 95  ? 139.221 96.807  99.505  1 69.776  ? 533 TYR A CD2 1 
ATOM   756  C CE1 . TYR A 1 95  ? 141.553 95.368  99.937  1 70.707  ? 533 TYR A CE1 1 
ATOM   757  C CE2 . TYR A 1 95  ? 140.455 97.411  99.288  1 67.531  ? 533 TYR A CE2 1 
ATOM   758  C CZ  . TYR A 1 95  ? 141.617 96.683  99.504  1 74.88   ? 533 TYR A CZ  1 
ATOM   759  O OH  . TYR A 1 95  ? 142.825 97.28   99.256  1 87.632  ? 533 TYR A OH  1 
ATOM   760  N N   . MET A 1 96  ? 135.728 95.682  98.009  1 67.074  ? 534 MET A N   1 
ATOM   761  C CA  . MET A 1 96  ? 135.265 96.617  97.005  1 67.841  ? 534 MET A CA  1 
ATOM   762  C C   . MET A 1 96  ? 135.396 98.025  97.557  1 65.806  ? 534 MET A C   1 
ATOM   763  O O   . MET A 1 96  ? 134.693 98.397  98.496  1 74.587  ? 534 MET A O   1 
ATOM   764  C CB  . MET A 1 96  ? 133.799 96.337  96.639  1 69.516  ? 534 MET A CB  1 
ATOM   765  C CG  . MET A 1 96  ? 133.26  97.24   95.528  1 74.95   ? 534 MET A CG  1 
ATOM   766  S SD  . MET A 1 96  ? 134.211 97.086  94      1 67.868  ? 534 MET A SD  1 
ATOM   767  C CE  . MET A 1 96  ? 134.305 95.309  93.802  1 67.029  ? 534 MET A CE  1 
ATOM   768  N N   . PRO A 1 97  ? 136.293 98.867  97.011  1 72.044  ? 535 PRO A N   1 
ATOM   769  C CA  . PRO A 1 97  ? 136.4   100.24  97.478  1 62.932  ? 535 PRO A CA  1 
ATOM   770  C C   . PRO A 1 97  ? 135.225 101.106 97.019  1 66.993  ? 535 PRO A C   1 
ATOM   771  O O   . PRO A 1 97  ? 134.902 101.141 95.839  1 67.715  ? 535 PRO A O   1 
ATOM   772  C CB  . PRO A 1 97  ? 137.719 100.74  96.86   1 67.481  ? 535 PRO A CB  1 
ATOM   773  C CG  . PRO A 1 97  ? 138.333 99.547  96.158  1 66.436  ? 535 PRO A CG  1 
ATOM   774  C CD  . PRO A 1 97  ? 137.246 98.542  95.938  1 70.417  ? 535 PRO A CD  1 
ATOM   775  N N   . ILE A 1 98  ? 134.585 101.805 97.954  1 67.774  ? 536 ILE A N   1 
ATOM   776  C CA  . ILE A 1 98  ? 133.533 102.748 97.62   1 62.983  ? 536 ILE A CA  1 
ATOM   777  C C   . ILE A 1 98  ? 134.043 104.141 97.951  1 67.109  ? 536 ILE A C   1 
ATOM   778  O O   . ILE A 1 98  ? 134.375 104.415 99.104  1 67.956  ? 536 ILE A O   1 
ATOM   779  C CB  . ILE A 1 98  ? 132.231 102.431 98.384  1 67.371  ? 536 ILE A CB  1 
ATOM   780  C CG1 . ILE A 1 98  ? 131.879 100.957 98.342  1 67.844  ? 536 ILE A CG1 1 
ATOM   781  C CG2 . ILE A 1 98  ? 131.087 103.3   97.879  1 67.335  ? 536 ILE A CG2 1 
ATOM   782  C CD1 . ILE A 1 98  ? 131.646 100.441 96.956  1 66.873  ? 536 ILE A CD1 1 
ATOM   783  N N   . PRO A 1 99  ? 134.114 105.078 96.983  1 65.897  ? 537 PRO A N   1 
ATOM   784  C CA  . PRO A 1 99  ? 134.6   106.41  97.297  1 65.957  ? 537 PRO A CA  1 
ATOM   785  C C   . PRO A 1 99  ? 133.761 107.043 98.401  1 72.122  ? 537 PRO A C   1 
ATOM   786  O O   . PRO A 1 99  ? 132.535 106.896 98.415  1 72.537  ? 537 PRO A O   1 
ATOM   787  C CB  . PRO A 1 99  ? 134.452 107.177 95.975  1 68.55   ? 537 PRO A CB  1 
ATOM   788  C CG  . PRO A 1 99  ? 134.365 106.106 94.916  1 70.286  ? 537 PRO A CG  1 
ATOM   789  C CD  . PRO A 1 99  ? 133.717 104.923 95.575  1 66.904  ? 537 PRO A CD  1 
ATOM   790  N N   . VAL A 1 100 ? 134.414 107.798 99.28   1 67.227  ? 538 VAL A N   1 
ATOM   791  C CA  . VAL A 1 100 ? 133.74  108.443 100.387 1 65.821  ? 538 VAL A CA  1 
ATOM   792  C C   . VAL A 1 100 ? 133.94  109.94  100.268 1 64.334  ? 538 VAL A C   1 
ATOM   793  O O   . VAL A 1 100 ? 135.068 110.402 100.306 1 67.827  ? 538 VAL A O   1 
ATOM   794  C CB  . VAL A 1 100 ? 134.252 107.939 101.751 1 68.855  ? 538 VAL A CB  1 
ATOM   795  C CG1 . VAL A 1 100 ? 133.606 108.699 102.9   1 74.71   ? 538 VAL A CG1 1 
ATOM   796  C CG2 . VAL A 1 100 ? 134.044 106.457 101.9   1 68.407  ? 538 VAL A CG2 1 
ATOM   797  N N   . GLY A 1 101 ? 132.824 110.666 100.143 1 61.972  ? 539 GLY A N   1 
ATOM   798  C CA  . GLY A 1 101 ? 132.825 112.111 100.168 1 65.881  ? 539 GLY A CA  1 
ATOM   799  C C   . GLY A 1 101 ? 132.261 112.599 101.492 1 64.639  ? 539 GLY A C   1 
ATOM   800  O O   . GLY A 1 101 ? 131.815 111.804 102.318 1 74.889  ? 539 GLY A O   1 
ATOM   801  N N   . VAL A 1 102 ? 132.301 113.905 101.702 1 60.123  ? 540 VAL A N   1 
ATOM   802  C CA  . VAL A 1 102 ? 131.857 114.479 102.954 1 67.256  ? 540 VAL A CA  1 
ATOM   803  C C   . VAL A 1 102 ? 130.894 115.616 102.641 1 65.694  ? 540 VAL A C   1 
ATOM   804  O O   . VAL A 1 102 ? 131.234 116.526 101.888 1 71.799  ? 540 VAL A O   1 
ATOM   805  C CB  . VAL A 1 102 ? 133.03  114.937 103.853 1 69.906  ? 540 VAL A CB  1 
ATOM   806  C CG1 . VAL A 1 102 ? 134.04  115.778 103.101 1 84.905  ? 540 VAL A CG1 1 
ATOM   807  C CG2 . VAL A 1 102 ? 132.528 115.725 105.055 1 74.778  ? 540 VAL A CG2 1 
ATOM   808  N N   . ALA A 1 103 ? 129.696 115.552 103.236 1 65.694  ? 541 ALA A N   1 
ATOM   809  C CA  . ALA A 1 103 ? 128.751 116.661 103.164 1 73.608  ? 541 ALA A CA  1 
ATOM   810  C C   . ALA A 1 103 ? 128.696 117.37  104.507 1 71.627  ? 541 ALA A C   1 
ATOM   811  O O   . ALA A 1 103 ? 128.595 116.727 105.545 1 87.736  ? 541 ALA A O   1 
ATOM   812  C CB  . ALA A 1 103 ? 127.382 116.154 102.779 1 73.904  ? 541 ALA A CB  1 
ATOM   813  N N   . GLY A 1 104 ? 128.778 118.693 104.494 1 75.988  ? 542 GLY A N   1 
ATOM   814  C CA  . GLY A 1 104 ? 128.682 119.425 105.734 1 76.436  ? 542 GLY A CA  1 
ATOM   815  C C   . GLY A 1 104 ? 129.426 120.741 105.672 1 72.919  ? 542 GLY A C   1 
ATOM   816  O O   . GLY A 1 104 ? 129.927 121.127 104.62  1 88.975  ? 542 GLY A O   1 
ATOM   817  N N   . PRO A 1 105 ? 129.471 121.496 106.789 1 76.631  ? 543 PRO A N   1 
ATOM   818  C CA  . PRO A 1 105 ? 128.87  121.09  108.058 1 81.481  ? 543 PRO A CA  1 
ATOM   819  C C   . PRO A 1 105 ? 127.332 121.08  108.057 1 72.783  ? 543 PRO A C   1 
ATOM   820  O O   . PRO A 1 105 ? 126.704 121.982 107.54  1 77.602  ? 543 PRO A O   1 
ATOM   821  C CB  . PRO A 1 105 ? 129.389 122.163 109.02  1 75.341  ? 543 PRO A CB  1 
ATOM   822  C CG  . PRO A 1 105 ? 129.519 123.38  108.118 1 73.414  ? 543 PRO A CG  1 
ATOM   823  C CD  . PRO A 1 105 ? 130.083 122.826 106.855 1 73.723  ? 543 PRO A CD  1 
ATOM   824  N N   . LEU A 1 106 ? 126.73  120.048 108.642 1 71.97   ? 544 LEU A N   1 
ATOM   825  C CA  . LEU A 1 106 ? 125.299 120.022 108.882 1 72.57   ? 544 LEU A CA  1 
ATOM   826  C C   . LEU A 1 106 ? 125.021 120.576 110.278 1 69.16   ? 544 LEU A C   1 
ATOM   827  O O   . LEU A 1 106 ? 125.508 120.039 111.263 1 73.646  ? 544 LEU A O   1 
ATOM   828  C CB  . LEU A 1 106 ? 124.771 118.597 108.735 1 72.253  ? 544 LEU A CB  1 
ATOM   829  C CG  . LEU A 1 106 ? 123.266 118.419 108.946 1 76.545  ? 544 LEU A CG  1 
ATOM   830  C CD1 . LEU A 1 106 ? 122.515 119.192 107.896 1 81.688  ? 544 LEU A CD1 1 
ATOM   831  C CD2 . LEU A 1 106 ? 122.855 116.972 108.958 1 84.563  ? 544 LEU A CD2 1 
ATOM   832  N N   . CYS A 1 107 ? 124.298 121.694 110.345 1 68.808  ? 545 CYS A N   1 
ATOM   833  C CA  . CYS A 1 107 ? 123.985 122.342 111.609 1 73.887  ? 545 CYS A CA  1 
ATOM   834  C C   . CYS A 1 107 ? 122.699 121.743 112.166 1 72.009  ? 545 CYS A C   1 
ATOM   835  O O   . CYS A 1 107 ? 121.624 122.076 111.696 1 74.963  ? 545 CYS A O   1 
ATOM   836  C CB  . CYS A 1 107 ? 123.795 123.842 111.429 1 75.274  ? 545 CYS A CB  1 
ATOM   837  S SG  . CYS A 1 107 ? 125.216 124.633 110.622 1 102.969 ? 545 CYS A SG  1 
ATOM   838  N N   . LEU A 1 108 ? 122.825 120.858 113.149 1 70.88   ? 546 LEU A N   1 
ATOM   839  C CA  . LEU A 1 108 ? 121.711 120.085 113.65  1 73.765  ? 546 LEU A CA  1 
ATOM   840  C C   . LEU A 1 108 ? 121.711 120.15  115.176 1 76.242  ? 546 LEU A C   1 
ATOM   841  O O   . LEU A 1 108 ? 122.704 119.849 115.815 1 77.922  ? 546 LEU A O   1 
ATOM   842  C CB  . LEU A 1 108 ? 121.816 118.646 113.145 1 72.935  ? 546 LEU A CB  1 
ATOM   843  C CG  . LEU A 1 108 ? 120.804 117.656 113.721 1 76.179  ? 546 LEU A CG  1 
ATOM   844  C CD1 . LEU A 1 108 ? 119.42  117.98  113.232 1 85.182  ? 546 LEU A CD1 1 
ATOM   845  C CD2 . LEU A 1 108 ? 121.154 116.233 113.372 1 86.001  ? 546 LEU A CD2 1 
ATOM   846  N N   . ASP A 1 109 ? 120.567 120.542 115.744 1 79.869  ? 547 ASP A N   1 
ATOM   847  C CA  . ASP A 1 109 ? 120.372 120.612 117.186 1 78.804  ? 547 ASP A CA  1 
ATOM   848  C C   . ASP A 1 109 ? 121.535 121.326 117.868 1 69.883  ? 547 ASP A C   1 
ATOM   849  O O   . ASP A 1 109 ? 122.029 120.858 118.884 1 83.906  ? 547 ASP A O   1 
ATOM   850  C CB  . ASP A 1 109 ? 120.135 119.225 117.755 1 77.604  ? 547 ASP A CB  1 
ATOM   851  C CG  . ASP A 1 109 ? 118.946 118.51  117.12  1 89.417  ? 547 ASP A CG  1 
ATOM   852  O OD1 . ASP A 1 109 ? 117.826 119.045 117.268 1 85.068  ? 547 ASP A OD1 1 
ATOM   853  O OD2 . ASP A 1 109 ? 119.137 117.442 116.479 1 81.069  ? 547 ASP A OD2 1 
ATOM   854  N N   . GLU A 1 110 ? 121.952 122.456 117.292 1 82.927  ? 548 GLU A N   1 
ATOM   855  C CA  . GLU A 1 110 ? 122.943 123.36  117.864 1 82.178  ? 548 GLU A CA  1 
ATOM   856  C C   . GLU A 1 110 ? 124.364 122.807 117.785 1 84.381  ? 548 GLU A C   1 
ATOM   857  O O   . GLU A 1 110 ? 125.283 123.396 118.346 1 99.523  ? 548 GLU A O   1 
ATOM   858  C CB  . GLU A 1 110 ? 122.6   123.732 119.308 1 91.622  ? 548 GLU A CB  1 
ATOM   859  C CG  . GLU A 1 110 ? 121.266 124.46  119.459 1 94.495  ? 548 GLU A CG  1 
ATOM   860  C CD  . GLU A 1 110 ? 121.12  125.706 118.603 1 115.456 ? 548 GLU A CD  1 
ATOM   861  O OE1 . GLU A 1 110 ? 120.026 126.32  118.628 1 136.575 ? 548 GLU A OE1 1 
ATOM   862  O OE2 . GLU A 1 110 ? 122.092 126.055 117.894 1 122.403 ? 548 GLU A OE2 1 
ATOM   863  N N   . LYS A 1 111 ? 124.562 121.705 117.058 1 87.237  ? 549 LYS A N   1 
ATOM   864  C CA  . LYS A 1 111 ? 125.884 121.143 116.837 1 79.502  ? 549 LYS A CA  1 
ATOM   865  C C   . LYS A 1 111 ? 126.181 121.127 115.339 1 77.667  ? 549 LYS A C   1 
ATOM   866  O O   . LYS A 1 111 ? 125.306 121.416 114.529 1 94.352  ? 549 LYS A O   1 
ATOM   867  C CB  . LYS A 1 111 ? 125.957 119.739 117.435 1 79.945  ? 549 LYS A CB  1 
ATOM   868  C CG  . LYS A 1 111 ? 126.032 119.721 118.939 1 96.255  ? 549 LYS A CG  1 
ATOM   869  C CD  . LYS A 1 111 ? 126.265 118.333 119.513 1 108.674 ? 549 LYS A CD  1 
ATOM   870  C CE  . LYS A 1 111 ? 125.055 117.759 120.17  1 117.579 ? 549 LYS A CE  1 
ATOM   871  N NZ  . LYS A 1 111 ? 123.898 117.729 119.273 1 122.532 ? 549 LYS A NZ  1 
ATOM   872  N N   . GLU A 1 112 ? 127.427 120.816 114.98  1 76.692  ? 550 GLU A N   1 
ATOM   873  C CA  . GLU A 1 112 ? 127.836 120.742 113.588 1 74.168  ? 550 GLU A CA  1 
ATOM   874  C C   . GLU A 1 112 ? 128.412 119.36  113.335 1 77.719  ? 550 GLU A C   1 
ATOM   875  O O   . GLU A 1 112 ? 129.179 118.844 114.138 1 94.559  ? 550 GLU A O   1 
ATOM   876  C CB  . GLU A 1 112 ? 128.868 121.786 113.197 1 80.194  ? 550 GLU A CB  1 
ATOM   877  C CG  . GLU A 1 112 ? 128.48  123.184 113.656 1 90.182  ? 550 GLU A CG  1 
ATOM   878  C CD  . GLU A 1 112 ? 128.679 124.194 112.56  1 110.242 ? 550 GLU A CD  1 
ATOM   879  O OE1 . GLU A 1 112 ? 127.86  124.075 111.625 1 126.296 ? 550 GLU A OE1 1 
ATOM   880  O OE2 . GLU A 1 112 ? 129.596 125.054 112.604 1 128.707 ? 550 GLU A OE2 1 
ATOM   881  N N   . PHE A 1 113 ? 127.998 118.751 112.229 1 75.619  ? 551 PHE A N   1 
ATOM   882  C CA  . PHE A 1 113 ? 128.473 117.438 111.865 1 69.185  ? 551 PHE A CA  1 
ATOM   883  C C   . PHE A 1 113 ? 129.08  117.478 110.471 1 65.049  ? 551 PHE A C   1 
ATOM   884  O O   . PHE A 1 113 ? 128.726 118.309 109.657 1 67.622  ? 551 PHE A O   1 
ATOM   885  C CB  . PHE A 1 113 ? 127.325 116.437 111.898 1 73.555  ? 551 PHE A CB  1 
ATOM   886  C CG  . PHE A 1 113 ? 126.741 116.255 113.278 1 75.899  ? 551 PHE A CG  1 
ATOM   887  C CD1 . PHE A 1 113 ? 127.294 115.341 114.161 1 71.668  ? 551 PHE A CD1 1 
ATOM   888  C CD2 . PHE A 1 113 ? 125.657 117.018 113.688 1 78.743  ? 551 PHE A CD2 1 
ATOM   889  C CE1 . PHE A 1 113 ? 126.747 115.176 115.416 1 73.606  ? 551 PHE A CE1 1 
ATOM   890  C CE2 . PHE A 1 113 ? 125.131 116.859 114.952 1 78.239  ? 551 PHE A CE2 1 
ATOM   891  C CZ  . PHE A 1 113 ? 125.673 115.934 115.811 1 77.164  ? 551 PHE A CZ  1 
ATOM   892  N N   . GLN A 1 114 ? 129.996 116.551 110.212 1 71.362  ? 552 GLN A N   1 
ATOM   893  C CA  . GLN A 1 114 ? 130.571 116.334 108.901 1 67.695  ? 552 GLN A CA  1 
ATOM   894  C C   . GLN A 1 114 ? 130.196 114.915 108.514 1 65.77   ? 552 GLN A C   1 
ATOM   895  O O   . GLN A 1 114 ? 130.671 113.955 109.105 1 70.594  ? 552 GLN A O   1 
ATOM   896  C CB  . GLN A 1 114 ? 132.09  116.52  108.945 1 75.188  ? 552 GLN A CB  1 
ATOM   897  C CG  . GLN A 1 114 ? 132.534 117.895 109.437 1 71.273  ? 552 GLN A CG  1 
ATOM   898  C CD  . GLN A 1 114 ? 132.296 118.982 108.418 1 81.277  ? 552 GLN A CD  1 
ATOM   899  O OE1 . GLN A 1 114 ? 132.046 118.706 107.24  1 88.588  ? 552 GLN A OE1 1 
ATOM   900  N NE2 . GLN A 1 114 ? 132.347 120.232 108.858 1 86.995  ? 552 GLN A NE2 1 
ATOM   901  N N   . VAL A 1 115 ? 129.297 114.787 107.532 1 68.669  ? 553 VAL A N   1 
ATOM   902  C CA  . VAL A 1 115 ? 128.627 113.518 107.297 1 67.55   ? 553 VAL A CA  1 
ATOM   903  C C   . VAL A 1 115 ? 129.352 112.795 106.169 1 66.095  ? 553 VAL A C   1 
ATOM   904  O O   . VAL A 1 115 ? 129.456 113.325 105.075 1 70.358  ? 553 VAL A O   1 
ATOM   905  C CB  . VAL A 1 115 ? 127.136 113.748 106.978 1 65.496  ? 553 VAL A CB  1 
ATOM   906  C CG1 . VAL A 1 115 ? 126.362 112.431 106.925 1 59.483  ? 553 VAL A CG1 1 
ATOM   907  C CG2 . VAL A 1 115 ? 126.536 114.713 107.986 1 64.092  ? 553 VAL A CG2 1 
ATOM   908  N N   . PRO A 1 116 ? 129.929 111.61  106.405 1 64.389  ? 554 PRO A N   1 
ATOM   909  C CA  . PRO A 1 116 ? 130.52  110.845 105.317 1 72.653  ? 554 PRO A CA  1 
ATOM   910  C C   . PRO A 1 116 ? 129.47  110.123 104.478 1 67.722  ? 554 PRO A C   1 
ATOM   911  O O   . PRO A 1 116 ? 128.536 109.545 105.018 1 65.091  ? 554 PRO A O   1 
ATOM   912  C CB  . PRO A 1 116 ? 131.451 109.853 106.029 1 63.338  ? 554 PRO A CB  1 
ATOM   913  C CG  . PRO A 1 116 ? 130.776 109.643 107.367 1 71.897  ? 554 PRO A CG  1 
ATOM   914  C CD  . PRO A 1 116 ? 130.113 110.972 107.718 1 69.192  ? 554 PRO A CD  1 
ATOM   915  N N   . MET A 1 117 ? 129.636 110.166 103.158 1 66.334  ? 555 MET A N   1 
ATOM   916  C CA  . MET A 1 117 ? 128.715 109.536 102.233 1 63.406  ? 555 MET A CA  1 
ATOM   917  C C   . MET A 1 117 ? 129.527 108.707 101.241 1 62.594  ? 555 MET A C   1 
ATOM   918  O O   . MET A 1 117 ? 130.336 109.246 100.504 1 65.282  ? 555 MET A O   1 
ATOM   919  C CB  . MET A 1 117 ? 127.869 110.585 101.511 1 59.401  ? 555 MET A CB  1 
ATOM   920  C CG  . MET A 1 117 ? 127.013 111.43  102.448 1 68.786  ? 555 MET A CG  1 
ATOM   921  S SD  . MET A 1 117 ? 126.105 112.798 101.689 1 73.554  ? 555 MET A SD  1 
ATOM   922  C CE  . MET A 1 117 ? 125.032 111.977 100.517 1 75.285  ? 555 MET A CE  1 
ATOM   923  N N   . ALA A 1 118 ? 129.301 107.396 101.255 1 61.138  ? 556 ALA A N   1 
ATOM   924  C CA  . ALA A 1 118 ? 129.938 106.486 100.339 1 66.827  ? 556 ALA A CA  1 
ATOM   925  C C   . ALA A 1 118 ? 129.022 106.251 99.149  1 67.045  ? 556 ALA A C   1 
ATOM   926  O O   . ALA A 1 118 ? 128.083 105.474 99.239  1 81.188  ? 556 ALA A O   1 
ATOM   927  C CB  . ALA A 1 118 ? 130.263 105.194 101.044 1 58.81   ? 556 ALA A CB  1 
ATOM   928  N N   . THR A 1 119 ? 129.364 106.822 98.003  1 70.266  ? 557 THR A N   1 
ATOM   929  C CA  . THR A 1 119 ? 128.509 106.703 96.835  1 81.402  ? 557 THR A CA  1 
ATOM   930  C C   . THR A 1 119 ? 129.345 106.618 95.564  1 75.258  ? 557 THR A C   1 
ATOM   931  O O   . THR A 1 119 ? 130.449 107.153 95.523  1 76.958  ? 557 THR A O   1 
ATOM   932  C CB  . THR A 1 119 ? 127.555 107.903 96.821  1 81.863  ? 557 THR A CB  1 
ATOM   933  O OG1 . THR A 1 119 ? 126.864 107.904 95.575  1 88.887  ? 557 THR A OG1 1 
ATOM   934  C CG2 . THR A 1 119 ? 128.275 109.225 97.003  1 78.41   ? 557 THR A CG2 1 
ATOM   935  N N   . THR A 1 120 ? 128.739 106.048 94.512  1 71.227  ? 558 THR A N   1 
ATOM   936  C CA  . THR A 1 120 ? 129.284 106.187 93.163  1 79.151  ? 558 THR A CA  1 
ATOM   937  C C   . THR A 1 120 ? 128.39  107.047 92.271  1 69.496  ? 558 THR A C   1 
ATOM   938  O O   . THR A 1 120 ? 128.563 107.062 91.057  1 83.113  ? 558 THR A O   1 
ATOM   939  C CB  . THR A 1 120 ? 129.531 104.824 92.522  1 77.461  ? 558 THR A CB  1 
ATOM   940  O OG1 . THR A 1 120 ? 128.294 104.113 92.485  1 77.459  ? 558 THR A OG1 1 
ATOM   941  C CG2 . THR A 1 120 ? 130.535 103.998 93.304  1 77.602  ? 558 THR A CG2 1 
ATOM   942  N N   . GLU A 1 121 ? 127.443 107.765 92.863  1 68.505  ? 559 GLU A N   1 
ATOM   943  C CA  . GLU A 1 121 ? 126.507 108.571 92.104  1 73.942  ? 559 GLU A CA  1 
ATOM   944  C C   . GLU A 1 121 ? 127.025 109.996 92.047  1 70.932  ? 559 GLU A C   1 
ATOM   945  O O   . GLU A 1 121 ? 127.077 110.663 93.076  1 80.327  ? 559 GLU A O   1 
ATOM   946  C CB  . GLU A 1 121 ? 125.107 108.511 92.705  1 78.166  ? 559 GLU A CB  1 
ATOM   947  C CG  . GLU A 1 121 ? 124.149 109.48  92.031  1 87.41   ? 559 GLU A CG  1 
ATOM   948  C CD  . GLU A 1 121 ? 122.722 109.392 92.525  1 98.366  ? 559 GLU A CD  1 
ATOM   949  O OE1 . GLU A 1 121 ? 121.859 109.917 91.789  1 98.389  ? 559 GLU A OE1 1 
ATOM   950  O OE2 . GLU A 1 121 ? 122.478 108.826 93.618  1 114.561 ? 559 GLU A OE2 1 
ATOM   951  N N   . GLY A 1 122 ? 127.362 110.458 90.838  1 71.39   ? 560 GLY A N   1 
ATOM   952  C CA  . GLY A 1 122 ? 127.925 111.787 90.646  1 72.971  ? 560 GLY A CA  1 
ATOM   953  C C   . GLY A 1 122 ? 126.947 112.886 91.066  1 69.593  ? 560 GLY A C   1 
ATOM   954  O O   . GLY A 1 122 ? 125.769 112.841 90.74   1 79.676  ? 560 GLY A O   1 
ATOM   955  N N   . CYS A 1 123 ? 127.459 113.866 91.802  1 62.46   ? 561 CYS A N   1 
ATOM   956  C CA  . CYS A 1 123 ? 126.732 115.06  92.171  1 64.512  ? 561 CYS A CA  1 
ATOM   957  C C   . CYS A 1 123 ? 125.87  114.875 93.413  1 60.035  ? 561 CYS A C   1 
ATOM   958  O O   . CYS A 1 123 ? 125.349 115.852 93.914  1 67.541  ? 561 CYS A O   1 
ATOM   959  C CB  . CYS A 1 123 ? 125.87  115.562 91.026  1 77.462  ? 561 CYS A CB  1 
ATOM   960  S SG  . CYS A 1 123 ? 126.831 115.903 89.532  1 95.851  ? 561 CYS A SG  1 
ATOM   961  N N   . LEU A 1 124 ? 125.73  113.657 93.933  1 59.227  ? 562 LEU A N   1 
ATOM   962  C CA  . LEU A 1 124 ? 124.944 113.465 95.132  1 61.056  ? 562 LEU A CA  1 
ATOM   963  C C   . LEU A 1 124 ? 125.525 114.249 96.312  1 67.119  ? 562 LEU A C   1 
ATOM   964  O O   . LEU A 1 124 ? 124.808 114.954 97.021  1 68.396  ? 562 LEU A O   1 
ATOM   965  C CB  . LEU A 1 124 ? 124.828 111.983 95.432  1 63.503  ? 562 LEU A CB  1 
ATOM   966  C CG  . LEU A 1 124 ? 124.13  111.618 96.742  1 69.983  ? 562 LEU A CG  1 
ATOM   967  C CD1 . LEU A 1 124 ? 122.693 112.108 96.735  1 69.166  ? 562 LEU A CD1 1 
ATOM   968  C CD2 . LEU A 1 124 ? 124.234 110.124 96.949  1 68.236  ? 562 LEU A CD2 1 
ATOM   969  N N   . VAL A 1 125 ? 126.826 114.152 96.521  1 67.101  ? 563 VAL A N   1 
ATOM   970  C CA  . VAL A 1 125 ? 127.453 114.823 97.646  1 58.38   ? 563 VAL A CA  1 
ATOM   971  C C   . VAL A 1 125 ? 127.365 116.333 97.499  1 64.451  ? 563 VAL A C   1 
ATOM   972  O O   . VAL A 1 125 ? 127.088 117.033 98.475  1 63.043  ? 563 VAL A O   1 
ATOM   973  C CB  . VAL A 1 125 ? 128.907 114.355 97.824  1 67.15   ? 563 VAL A CB  1 
ATOM   974  C CG1 . VAL A 1 125 ? 129.646 115.201 98.833  1 66.702  ? 563 VAL A CG1 1 
ATOM   975  C CG2 . VAL A 1 125 ? 128.968 112.885 98.222  1 67.737  ? 563 VAL A CG2 1 
ATOM   976  N N   . ALA A 1 126 ? 127.588 116.841 96.287  1 62.629  ? 564 ALA A N   1 
ATOM   977  C CA  . ALA A 1 126 ? 127.517 118.273 96.062  1 67.547  ? 564 ALA A CA  1 
ATOM   978  C C   . ALA A 1 126 ? 126.107 118.815 96.335  1 67.853  ? 564 ALA A C   1 
ATOM   979  O O   . ALA A 1 126 ? 125.95  119.877 96.934  1 71.037  ? 564 ALA A O   1 
ATOM   980  C CB  . ALA A 1 126 ? 127.955 118.562 94.646  1 72.4    ? 564 ALA A CB  1 
ATOM   981  N N   . SER A 1 127 ? 125.075 118.084 95.892  1 68.303  ? 565 SER A N   1 
ATOM   982  C CA  . SER A 1 127 ? 123.697 118.487 96.116  1 69.038  ? 565 SER A CA  1 
ATOM   983  C C   . SER A 1 127 ? 123.38  118.489 97.611  1 64.096  ? 565 SER A C   1 
ATOM   984  O O   . SER A 1 127 ? 122.806 119.44  98.131  1 62.219  ? 565 SER A O   1 
ATOM   985  C CB  . SER A 1 127 ? 122.748 117.59  95.363  1 76.329  ? 565 SER A CB  1 
ATOM   986  O OG  . SER A 1 127 ? 121.428 118.128 95.399  1 76.969  ? 565 SER A OG  1 
ATOM   987  N N   . THR A 1 128 ? 123.792 117.419 98.307  1 61.007  ? 566 THR A N   1 
ATOM   988  C CA  . THR A 1 128 ? 123.59  117.374 99.746  1 69.286  ? 566 THR A CA  1 
ATOM   989  C C   . THR A 1 128 ? 124.302 118.556 100.414 1 67.85   ? 566 THR A C   1 
ATOM   990  O O   . THR A 1 128 ? 123.79  119.134 101.371 1 66.97   ? 566 THR A O   1 
ATOM   991  C CB  . THR A 1 128 ? 124.06  116.051 100.325 1 67.862  ? 566 THR A CB  1 
ATOM   992  O OG1 . THR A 1 128 ? 123.517 115.004 99.524  1 69.026  ? 566 THR A OG1 1 
ATOM   993  C CG2 . THR A 1 128 ? 123.628 115.883 101.764 1 68.654  ? 566 THR A CG2 1 
ATOM   994  N N   . ASN A 1 129 ? 125.492 118.903 99.923  1 66.508  ? 567 ASN A N   1 
ATOM   995  C CA  . ASN A 1 129 ? 126.252 120.009 100.479 1 66.394  ? 567 ASN A CA  1 
ATOM   996  C C   . ASN A 1 129 ? 125.509 121.328 100.327 1 61.124  ? 567 ASN A C   1 
ATOM   997  O O   . ASN A 1 129 ? 125.491 122.151 101.236 1 63.496  ? 567 ASN A O   1 
ATOM   998  C CB  . ASN A 1 129 ? 127.633 120.126 99.851  1 70.831  ? 567 ASN A CB  1 
ATOM   999  C CG  . ASN A 1 129 ? 128.714 119.726 100.815 1 77.586  ? 567 ASN A CG  1 
ATOM   1000 O OD1 . ASN A 1 129 ? 128.829 120.333 101.886 1 85.909  ? 567 ASN A OD1 1 
ATOM   1001 N ND2 . ASN A 1 129 ? 129.498 118.716 100.461 1 95.796  ? 567 ASN A ND2 1 
ATOM   1002 N N   . ARG A 1 130 ? 124.905 121.544 99.165  1 63.611  ? 568 ARG A N   1 
ATOM   1003 C CA  . ARG A 1 130 ? 124.156 122.765 98.96   1 60.992  ? 568 ARG A CA  1 
ATOM   1004 C C   . ARG A 1 130 ? 122.974 122.818 99.929  1 67.059  ? 568 ARG A C   1 
ATOM   1005 O O   . ARG A 1 130 ? 122.659 123.843 100.515 1 62.82   ? 568 ARG A O   1 
ATOM   1006 C CB  . ARG A 1 130 ? 123.71  122.844 97.501  1 64.761  ? 568 ARG A CB  1 
ATOM   1007 C CG  . ARG A 1 130 ? 122.979 124.14  97.2    1 67.253  ? 568 ARG A CG  1 
ATOM   1008 C CD  . ARG A 1 130 ? 122.66  124.243 95.735  1 73.251  ? 568 ARG A CD  1 
ATOM   1009 N NE  . ARG A 1 130 ? 121.53  123.415 95.304  1 74.834  ? 568 ARG A NE  1 
ATOM   1010 C CZ  . ARG A 1 130 ? 120.627 123.818 94.415  1 77.95   ? 568 ARG A CZ  1 
ATOM   1011 N NH1 . ARG A 1 130 ? 120.75  124.991 93.817  1 73.103  ? 568 ARG A NH1 1 
ATOM   1012 N NH2 . ARG A 1 130 ? 119.62  123.023 94.099  1 68.423  ? 568 ARG A NH2 1 
ATOM   1013 N N   . GLY A 1 131 ? 122.288 121.69  100.098 1 70.059  ? 569 GLY A N   1 
ATOM   1014 C CA  . GLY A 1 131 ? 121.227 121.654 101.078 1 70.465  ? 569 GLY A CA  1 
ATOM   1015 C C   . GLY A 1 131 ? 121.714 121.976 102.495 1 67.467  ? 569 GLY A C   1 
ATOM   1016 O O   . GLY A 1 131 ? 121.065 122.705 103.232 1 60.286  ? 569 GLY A O   1 
ATOM   1017 N N   . CYS A 1 132 ? 122.847 121.393 102.893 1 65.312  ? 570 CYS A N   1 
ATOM   1018 C CA  . CYS A 1 132 ? 123.445 121.667 104.189 1 66.203  ? 570 CYS A CA  1 
ATOM   1019 C C   . CYS A 1 132 ? 123.735 123.153 104.355 1 59.863  ? 570 CYS A C   1 
ATOM   1020 O O   . CYS A 1 132 ? 123.466 123.736 105.402 1 66.894  ? 570 CYS A O   1 
ATOM   1021 C CB  . CYS A 1 132 ? 124.736 120.885 104.39  1 67.307  ? 570 CYS A CB  1 
ATOM   1022 S SG  . CYS A 1 132 ? 124.482 119.128 104.708 1 74.825  ? 570 CYS A SG  1 
ATOM   1023 N N   . ARG A 1 133 ? 124.245 123.781 103.304 1 67.62   ? 571 ARG A N   1 
ATOM   1024 C CA  . ARG A 1 133 ? 124.556 125.198 103.372 1 64.562  ? 571 ARG A CA  1 
ATOM   1025 C C   . ARG A 1 133 ? 123.292 126.032 103.561 1 75.17   ? 571 ARG A C   1 
ATOM   1026 O O   . ARG A 1 133 ? 123.265 126.98  104.343 1 71.182  ? 571 ARG A O   1 
ATOM   1027 C CB  . ARG A 1 133 ? 125.266 125.6   102.087 1 68.808  ? 571 ARG A CB  1 
ATOM   1028 C CG  . ARG A 1 133 ? 125.619 127.079 102.057 1 77.813  ? 571 ARG A CG  1 
ATOM   1029 C CD  . ARG A 1 133 ? 126.853 127.266 101.204 1 84.138  ? 571 ARG A CD  1 
ATOM   1030 N NE  . ARG A 1 133 ? 126.53  127.503 99.798  1 90.023  ? 571 ARG A NE  1 
ATOM   1031 C CZ  . ARG A 1 133 ? 126.24  128.705 99.318  1 107.207 ? 571 ARG A CZ  1 
ATOM   1032 N NH1 . ARG A 1 133 ? 126.232 129.767 100.124 1 103.778 ? 571 ARG A NH1 1 
ATOM   1033 N NH2 . ARG A 1 133 ? 125.967 128.839 98.028  1 103.225 ? 571 ARG A NH2 1 
ATOM   1034 N N   . ALA A 1 134 ? 122.234 125.689 102.822 1 76.076  ? 572 ALA A N   1 
ATOM   1035 C CA  . ALA A 1 134 ? 120.982 126.417 102.949 1 75.447  ? 572 ALA A CA  1 
ATOM   1036 C C   . ALA A 1 134 ? 120.455 126.313 104.381 1 69.174  ? 572 ALA A C   1 
ATOM   1037 O O   . ALA A 1 134 ? 120.074 127.307 104.992 1 64.949  ? 572 ALA A O   1 
ATOM   1038 C CB  . ALA A 1 134 ? 119.976 125.886 101.952 1 74.509  ? 572 ALA A CB  1 
ATOM   1039 N N   . ILE A 1 135 ? 120.463 125.092 104.924 1 67.431  ? 573 ILE A N   1 
ATOM   1040 C CA  . ILE A 1 135 ? 119.979 124.882 106.276 1 71.102  ? 573 ILE A CA  1 
ATOM   1041 C C   . ILE A 1 135 ? 120.816 125.68  107.274 1 69.897  ? 573 ILE A C   1 
ATOM   1042 O O   . ILE A 1 135 ? 120.273 126.296 108.195 1 77.761  ? 573 ILE A O   1 
ATOM   1043 C CB  . ILE A 1 135 ? 119.951 123.389 106.611 1 66.447  ? 573 ILE A CB  1 
ATOM   1044 C CG1 . ILE A 1 135 ? 118.856 122.657 105.854 1 67.437  ? 573 ILE A CG1 1 
ATOM   1045 C CG2 . ILE A 1 135 ? 119.833 123.186 108.113 1 63.587  ? 573 ILE A CG2 1 
ATOM   1046 C CD1 . ILE A 1 135 ? 118.96  121.146 105.985 1 70.896  ? 573 ILE A CD1 1 
ATOM   1047 N N   . GLY A 1 136 ? 122.135 125.666 107.093 1 74.88   ? 574 GLY A N   1 
ATOM   1048 C CA  . GLY A 1 136 ? 123.034 126.372 107.993 1 75.762  ? 574 GLY A CA  1 
ATOM   1049 C C   . GLY A 1 136 ? 122.76  127.868 108.004 1 72.029  ? 574 GLY A C   1 
ATOM   1050 O O   . GLY A 1 136 ? 122.727 128.481 109.066 1 85.432  ? 574 GLY A O   1 
ATOM   1051 N N   . LEU A 1 137 ? 122.546 128.447 106.819 1 75.963  ? 575 LEU A N   1 
ATOM   1052 C CA  . LEU A 1 137 ? 122.236 129.864 106.715 1 73.688  ? 575 LEU A CA  1 
ATOM   1053 C C   . LEU A 1 137 ? 120.853 130.144 107.291 1 79.806  ? 575 LEU A C   1 
ATOM   1054 O O   . LEU A 1 137 ? 120.535 131.264 107.658 1 83.389  ? 575 LEU A O   1 
ATOM   1055 C CB  . LEU A 1 137 ? 122.324 130.316 105.26  1 76.601  ? 575 LEU A CB  1 
ATOM   1056 C CG  . LEU A 1 137 ? 123.738 130.569 104.732 1 81.639  ? 575 LEU A CG  1 
ATOM   1057 C CD1 . LEU A 1 137 ? 123.713 130.806 103.24  1 77.306  ? 575 LEU A CD1 1 
ATOM   1058 C CD2 . LEU A 1 137 ? 124.373 131.748 105.463 1 80.491  ? 575 LEU A CD2 1 
ATOM   1059 N N   . GLY A 1 138 ? 120.019 129.107 107.347 1 91.563  ? 576 GLY A N   1 
ATOM   1060 C CA  . GLY A 1 138 ? 118.673 129.249 107.868 1 85.916  ? 576 GLY A CA  1 
ATOM   1061 C C   . GLY A 1 138 ? 118.58  129.204 109.391 1 84.895  ? 576 GLY A C   1 
ATOM   1062 O O   . GLY A 1 138 ? 117.479 129.3   109.925 1 96.525  ? 576 GLY A O   1 
ATOM   1063 N N   . GLY A 1 139 ? 119.703 129.039 110.096 1 80.974  ? 577 GLY A N   1 
ATOM   1064 C CA  . GLY A 1 139 ? 119.666 128.96  111.546 1 80.541  ? 577 GLY A CA  1 
ATOM   1065 C C   . GLY A 1 139 ? 119.621 127.527 112.08  1 73.67   ? 577 GLY A C   1 
ATOM   1066 O O   . GLY A 1 139 ? 119.294 127.309 113.242 1 85.575  ? 577 GLY A O   1 
ATOM   1067 N N   . GLY A 1 140 ? 119.979 126.555 111.243 1 73.682  ? 578 GLY A N   1 
ATOM   1068 C CA  . GLY A 1 140 ? 120.155 125.196 111.701 1 70.265  ? 578 GLY A CA  1 
ATOM   1069 C C   . GLY A 1 140 ? 118.843 124.427 111.732 1 68.75   ? 578 GLY A C   1 
ATOM   1070 O O   . GLY A 1 140 ? 117.763 124.992 111.667 1 78.233  ? 578 GLY A O   1 
ATOM   1071 N N   . ALA A 1 141 ? 118.972 123.115 111.857 1 66.052  ? 579 ALA A N   1 
ATOM   1072 C CA  . ALA A 1 141 ? 117.833 122.239 111.927 1 68.201  ? 579 ALA A CA  1 
ATOM   1073 C C   . ALA A 1 141 ? 117.65  121.711 113.346 1 68.639  ? 579 ALA A C   1 
ATOM   1074 O O   . ALA A 1 141 ? 118.497 121.864 114.214 1 78.153  ? 579 ALA A O   1 
ATOM   1075 C CB  . ALA A 1 141 ? 118.009 121.11  110.925 1 68.312  ? 579 ALA A CB  1 
ATOM   1076 N N   . SER A 1 142 ? 116.488 121.106 113.573 1 72.896  ? 580 SER A N   1 
ATOM   1077 C CA  . SER A 1 142 ? 116.111 120.549 114.863 1 70.308  ? 580 SER A CA  1 
ATOM   1078 C C   . SER A 1 142 ? 115.514 119.18  114.609 1 66.047  ? 580 SER A C   1 
ATOM   1079 O O   . SER A 1 142 ? 114.852 118.985 113.597 1 75.968  ? 580 SER A O   1 
ATOM   1080 C CB  . SER A 1 142 ? 115.112 121.422 115.592 1 71.632  ? 580 SER A CB  1 
ATOM   1081 O OG  . SER A 1 142 ? 115.692 122.648 116.015 1 87.281  ? 580 SER A OG  1 
ATOM   1082 N N   . SER A 1 143 ? 115.74  118.251 115.53  1 64.174  ? 581 SER A N   1 
ATOM   1083 C CA  . SER A 1 143 ? 115.263 116.902 115.368 1 66.41   ? 581 SER A CA  1 
ATOM   1084 C C   . SER A 1 143 ? 114.864 116.313 116.71  1 66.688  ? 581 SER A C   1 
ATOM   1085 O O   . SER A 1 143 ? 115.321 116.76  117.749 1 71.126  ? 581 SER A O   1 
ATOM   1086 C CB  . SER A 1 143 ? 116.299 116.028 114.673 1 77.582  ? 581 SER A CB  1 
ATOM   1087 O OG  . SER A 1 143 ? 117.449 115.867 115.483 1 83.073  ? 581 SER A OG  1 
ATOM   1088 N N   . ARG A 1 144 ? 114.029 115.269 116.653 1 65.483  ? 582 ARG A N   1 
ATOM   1089 C CA  . ARG A 1 144 ? 113.599 114.55  117.834 1 57.339  ? 582 ARG A CA  1 
ATOM   1090 C C   . ARG A 1 144 ? 113.45  113.092 117.474 1 61.515  ? 582 ARG A C   1 
ATOM   1091 O O   . ARG A 1 144 ? 112.907 112.764 116.437 1 70.189  ? 582 ARG A O   1 
ATOM   1092 C CB  . ARG A 1 144 ? 112.271 115.073 118.395 1 65.242  ? 582 ARG A CB  1 
ATOM   1093 C CG  . ARG A 1 144 ? 112.265 116.515 118.887 1 68.07   ? 582 ARG A CG  1 
ATOM   1094 C CD  . ARG A 1 144 ? 112.945 116.621 120.234 1 69.525  ? 582 ARG A CD  1 
ATOM   1095 N NE  . ARG A 1 144 ? 112.945 118     120.733 1 78.354  ? 582 ARG A NE  1 
ATOM   1096 C CZ  . ARG A 1 144 ? 113.729 118.972 120.3   1 73.437  ? 582 ARG A CZ  1 
ATOM   1097 N NH1 . ARG A 1 144 ? 114.651 118.719 119.401 1 76.835  ? 582 ARG A NH1 1 
ATOM   1098 N NH2 . ARG A 1 144 ? 113.567 120.208 120.727 1 78.746  ? 582 ARG A NH2 1 
ATOM   1099 N N   . VAL A 1 145 ? 113.896 112.216 118.359 1 65.096  ? 583 VAL A N   1 
ATOM   1100 C CA  . VAL A 1 145 ? 113.522 110.827 118.318 1 63.787  ? 583 VAL A CA  1 
ATOM   1101 C C   . VAL A 1 145 ? 112.154 110.666 118.977 1 67.544  ? 583 VAL A C   1 
ATOM   1102 O O   . VAL A 1 145 ? 111.961 111.031 120.124 1 84.343  ? 583 VAL A O   1 
ATOM   1103 C CB  . VAL A 1 145 ? 114.608 109.975 118.98  1 61.869  ? 583 VAL A CB  1 
ATOM   1104 C CG1 . VAL A 1 145 ? 114.272 108.496 118.95  1 63.372  ? 583 VAL A CG1 1 
ATOM   1105 C CG2 . VAL A 1 145 ? 115.957 110.197 118.318 1 65.067  ? 583 VAL A CG2 1 
ATOM   1106 N N   . LEU A 1 146 ? 111.217 110.054 118.247 1 65.505  ? 584 LEU A N   1 
ATOM   1107 C CA  . LEU A 1 146 ? 109.833 109.932 118.682 1 69.474  ? 584 LEU A CA  1 
ATOM   1108 C C   . LEU A 1 146 ? 109.583 108.55  119.285 1 61.845  ? 584 LEU A C   1 
ATOM   1109 O O   . LEU A 1 146 ? 108.783 108.407 120.186 1 77.672  ? 584 LEU A O   1 
ATOM   1110 C CB  . LEU A 1 146 ? 108.917 110.176 117.485 1 67.268  ? 584 LEU A CB  1 
ATOM   1111 C CG  . LEU A 1 146 ? 109.211 111.448 116.689 1 72.467  ? 584 LEU A CG  1 
ATOM   1112 C CD1 . LEU A 1 146 ? 108.459 111.46  115.393 1 71.823  ? 584 LEU A CD1 1 
ATOM   1113 C CD2 . LEU A 1 146 ? 108.914 112.699 117.484 1 68.785  ? 584 LEU A CD2 1 
ATOM   1114 N N   . ALA A 1 147 ? 110.213 107.52  118.742 1 63.618  ? 585 ALA A N   1 
ATOM   1115 C CA  . ALA A 1 147 ? 110.034 106.161 119.212 1 66.966  ? 585 ALA A CA  1 
ATOM   1116 C C   . ALA A 1 147 ? 111.302 105.389 118.907 1 62.933  ? 585 ALA A C   1 
ATOM   1117 O O   . ALA A 1 147 ? 112.043 105.746 117.997 1 71.464  ? 585 ALA A O   1 
ATOM   1118 C CB  . ALA A 1 147 ? 108.847 105.485 118.554 1 57.968  ? 585 ALA A CB  1 
ATOM   1119 N N   . ASP A 1 148 ? 111.516 104.311 119.647 1 66.708  ? 586 ASP A N   1 
ATOM   1120 C CA  . ASP A 1 148 ? 112.746 103.561 119.518 1 68.207  ? 586 ASP A CA  1 
ATOM   1121 C C   . ASP A 1 148 ? 112.495 102.13  119.956 1 64.359  ? 586 ASP A C   1 
ATOM   1122 O O   . ASP A 1 148 ? 112.254 101.866 121.117 1 77.652  ? 586 ASP A O   1 
ATOM   1123 C CB  . ASP A 1 148 ? 113.856 104.196 120.326 1 72.438  ? 586 ASP A CB  1 
ATOM   1124 C CG  . ASP A 1 148 ? 115.156 103.411 120.355 1 98.779  ? 586 ASP A CG  1 
ATOM   1125 O OD1 . ASP A 1 148 ? 115.262 102.398 119.62  1 108.364 ? 586 ASP A OD1 1 
ATOM   1126 O OD2 . ASP A 1 148 ? 116.058 103.823 121.123 1 112.392 ? 586 ASP A OD2 1 
ATOM   1127 N N   . GLY A 1 149 ? 112.584 101.206 119.008 1 65.107  ? 587 GLY A N   1 
ATOM   1128 C CA  . GLY A 1 149 ? 112.666 99.796  119.321 1 60.387  ? 587 GLY A CA  1 
ATOM   1129 C C   . GLY A 1 149 ? 112.708 98.965  118.056 1 62.676  ? 587 GLY A C   1 
ATOM   1130 O O   . GLY A 1 149 ? 111.907 99.176  117.156 1 68.007  ? 587 GLY A O   1 
ATOM   1131 N N   . MET A 1 150 ? 113.621 98.001  118.016 1 59.529  ? 588 MET A N   1 
ATOM   1132 C CA  . MET A 1 150 ? 113.705 97.064  116.924 1 59.926  ? 588 MET A CA  1 
ATOM   1133 C C   . MET A 1 150 ? 112.67  95.962  117.164 1 65.175  ? 588 MET A C   1 
ATOM   1134 O O   . MET A 1 150 ? 112.311 95.665  118.305 1 63.678  ? 588 MET A O   1 
ATOM   1135 C CB  . MET A 1 150 ? 115.128 96.498  116.862 1 67.251  ? 588 MET A CB  1 
ATOM   1136 C CG  . MET A 1 150 ? 115.346 95.34   115.943 1 74.329  ? 588 MET A CG  1 
ATOM   1137 S SD  . MET A 1 150 ? 114.834 95.688  114.262 1 76.872  ? 588 MET A SD  1 
ATOM   1138 C CE  . MET A 1 150 ? 115.441 97.328  113.896 1 69.897  ? 588 MET A CE  1 
ATOM   1139 N N   . THR A 1 151 ? 112.233 95.307  116.082 1 55.761  ? 589 THR A N   1 
ATOM   1140 C CA  . THR A 1 151 ? 111.13  94.353  116.196 1 62.99   ? 589 THR A CA  1 
ATOM   1141 C C   . THR A 1 151 ? 111.512 93.044  115.521 1 57.854  ? 589 THR A C   1 
ATOM   1142 O O   . THR A 1 151 ? 112.331 93.04   114.61  1 62.939  ? 589 THR A O   1 
ATOM   1143 C CB  . THR A 1 151 ? 109.809 94.902  115.633 1 63.37   ? 589 THR A CB  1 
ATOM   1144 O OG1 . THR A 1 151 ? 109.881 94.922  114.212 1 61.261  ? 589 THR A OG1 1 
ATOM   1145 C CG2 . THR A 1 151 ? 109.465 96.301  116.111 1 59.527  ? 589 THR A CG2 1 
ATOM   1146 N N   . ARG A 1 152 ? 110.894 91.952  115.98  1 58.556  ? 590 ARG A N   1 
ATOM   1147 C CA  . ARG A 1 152 ? 110.914 90.669  115.308 1 60.791  ? 590 ARG A CA  1 
ATOM   1148 C C   . ARG A 1 152 ? 109.493 90.083  115.291 1 66.681  ? 590 ARG A C   1 
ATOM   1149 O O   . ARG A 1 152 ? 108.835 90.02   116.313 1 67.513  ? 590 ARG A O   1 
ATOM   1150 C CB  . ARG A 1 152 ? 111.927 89.743  115.981 1 68.445  ? 590 ARG A CB  1 
ATOM   1151 C CG  . ARG A 1 152 ? 112.027 88.342  115.403 1 75.165  ? 590 ARG A CG  1 
ATOM   1152 C CD  . ARG A 1 152 ? 112.37  88.323  113.922 1 77.182  ? 590 ARG A CD  1 
ATOM   1153 N NE  . ARG A 1 152 ? 113.744 88.736  113.654 1 77.908  ? 590 ARG A NE  1 
ATOM   1154 C CZ  . ARG A 1 152 ? 114.284 88.923  112.451 1 79.177  ? 590 ARG A CZ  1 
ATOM   1155 N NH1 . ARG A 1 152 ? 113.556 88.843  111.345 1 78.266  ? 590 ARG A NH1 1 
ATOM   1156 N NH2 . ARG A 1 152 ? 115.571 89.176  112.374 1 87.694  ? 590 ARG A NH2 1 
ATOM   1157 N N   . GLY A 1 153 ? 109.013 89.673  114.115 1 68.214  ? 591 GLY A N   1 
ATOM   1158 C CA  . GLY A 1 153 ? 107.635 89.226  113.914 1 60.6    ? 591 GLY A CA  1 
ATOM   1159 C C   . GLY A 1 153 ? 107.541 87.725  113.657 1 63.046  ? 591 GLY A C   1 
ATOM   1160 O O   . GLY A 1 153 ? 107.319 87.284  112.526 1 67.238  ? 591 GLY A O   1 
ATOM   1161 N N   . PRO A 1 154 ? 107.72  86.849  114.674 1 60.942  ? 592 PRO A N   1 
ATOM   1162 C CA  . PRO A 1 154 ? 107.511 85.428  114.462 1 56.904  ? 592 PRO A CA  1 
ATOM   1163 C C   . PRO A 1 154 ? 106.061 85.092  114.073 1 63.233  ? 592 PRO A C   1 
ATOM   1164 O O   . PRO A 1 154 ? 105.123 85.825  114.409 1 60.867  ? 592 PRO A O   1 
ATOM   1165 C CB  . PRO A 1 154 ? 107.914 84.814  115.805 1 62.31   ? 592 PRO A CB  1 
ATOM   1166 C CG  . PRO A 1 154 ? 107.68  85.947  116.769 1 63.391  ? 592 PRO A CG  1 
ATOM   1167 C CD  . PRO A 1 154 ? 108.157 87.147  116.035 1 63.436  ? 592 PRO A CD  1 
ATOM   1168 N N   . VAL A 1 155 ? 105.898 83.934  113.445 1 58.494  ? 593 VAL A N   1 
ATOM   1169 C CA  . VAL A 1 155 ? 104.603 83.349  113.178 1 57.967  ? 593 VAL A CA  1 
ATOM   1170 C C   . VAL A 1 155 ? 104.524 81.969  113.815 1 58.184  ? 593 VAL A C   1 
ATOM   1171 O O   . VAL A 1 155 ? 105.39  81.111  113.576 1 60.354  ? 593 VAL A O   1 
ATOM   1172 C CB  . VAL A 1 155 ? 104.285 83.265  111.676 1 66.938  ? 593 VAL A CB  1 
ATOM   1173 C CG1 . VAL A 1 155 ? 105.305 82.419  110.912 1 63.594  ? 593 VAL A CG1 1 
ATOM   1174 C CG2 . VAL A 1 155 ? 102.837 82.808  111.472 1 69.235  ? 593 VAL A CG2 1 
ATOM   1175 N N   . VAL A 1 156 ? 103.456 81.772  114.593 1 56.991  ? 594 VAL A N   1 
ATOM   1176 C CA  . VAL A 1 156 ? 103.194 80.491  115.24  1 63.96   ? 594 VAL A CA  1 
ATOM   1177 C C   . VAL A 1 156 ? 101.834 79.992  114.77  1 58.751  ? 594 VAL A C   1 
ATOM   1178 O O   . VAL A 1 156 ? 101.025 80.751  114.249 1 61.362  ? 594 VAL A O   1 
ATOM   1179 C CB  . VAL A 1 156 ? 103.24  80.567  116.777 1 66.764  ? 594 VAL A CB  1 
ATOM   1180 C CG1 . VAL A 1 156 ? 104.559 81.162  117.26  1 68.102  ? 594 VAL A CG1 1 
ATOM   1181 C CG2 . VAL A 1 156 ? 102.074 81.365  117.347 1 64.66   ? 594 VAL A CG2 1 
ATOM   1182 N N   . ARG A 1 157 ? 101.597 78.702  114.918 1 61.244  ? 595 ARG A N   1 
ATOM   1183 C CA  . ARG A 1 157 ? 100.364 78.111  114.419 1 66.367  ? 595 ARG A CA  1 
ATOM   1184 C C   . ARG A 1 157 ? 99.718  77.238  115.49  1 70.339  ? 595 ARG A C   1 
ATOM   1185 O O   . ARG A 1 157 ? 100.414 76.469  116.156 1 68.378  ? 595 ARG A O   1 
ATOM   1186 C CB  . ARG A 1 157 ? 100.675 77.27   113.174 1 72.983  ? 595 ARG A CB  1 
ATOM   1187 C CG  . ARG A 1 157 ? 99.455  76.788  112.43  1 86.621  ? 595 ARG A CG  1 
ATOM   1188 C CD  . ARG A 1 157 ? 99.861  75.872  111.252 1 96.999  ? 595 ARG A CD  1 
ATOM   1189 N NE  . ARG A 1 157 ? 99.92   76.693  110.049 1 90.961  ? 595 ARG A NE  1 
ATOM   1190 C CZ  . ARG A 1 157 ? 99.085  76.548  109.044 1 89.864  ? 595 ARG A CZ  1 
ATOM   1191 N NH1 . ARG A 1 157 ? 99.042  75.405  108.398 1 114.712 ? 595 ARG A NH1 1 
ATOM   1192 N NH2 . ARG A 1 157 ? 98.508  77.629  108.56  1 80.697  ? 595 ARG A NH2 1 
ATOM   1193 N N   . LEU A 1 158 ? 98.389  77.365  115.624 1 63.089  ? 596 LEU A N   1 
ATOM   1194 C CA  . LEU A 1 158 ? 97.597  76.578  116.563 1 66.042  ? 596 LEU A CA  1 
ATOM   1195 C C   . LEU A 1 158 ? 96.725  75.588  115.811 1 62.241  ? 596 LEU A C   1 
ATOM   1196 O O   . LEU A 1 158 ? 96.518  75.726  114.62  1 64.325  ? 596 LEU A O   1 
ATOM   1197 C CB  . LEU A 1 158 ? 96.722  77.474  117.417 1 73.274  ? 596 LEU A CB  1 
ATOM   1198 C CG  . LEU A 1 158 ? 97.37   78.094  118.655 1 76.031  ? 596 LEU A CG  1 
ATOM   1199 C CD1 . LEU A 1 158 ? 97.821  77.008  119.614 1 78.581  ? 596 LEU A CD1 1 
ATOM   1200 C CD2 . LEU A 1 158 ? 98.524  79.037  118.298 1 73.721  ? 596 LEU A CD2 1 
ATOM   1201 N N   . PRO A 1 159 ? 96.217  74.526  116.464 1 70.49   ? 597 PRO A N   1 
ATOM   1202 C CA  . PRO A 1 159 ? 95.367  73.57   115.768 1 75.169  ? 597 PRO A CA  1 
ATOM   1203 C C   . PRO A 1 159 ? 94.132  74.205  115.143 1 69.866  ? 597 PRO A C   1 
ATOM   1204 O O   . PRO A 1 159 ? 93.699  73.763  114.093 1 83.836  ? 597 PRO A O   1 
ATOM   1205 C CB  . PRO A 1 159 ? 94.979  72.56   116.845 1 75.728  ? 597 PRO A CB  1 
ATOM   1206 C CG  . PRO A 1 159 ? 96.074  72.732  117.882 1 76.501  ? 597 PRO A CG  1 
ATOM   1207 C CD  . PRO A 1 159 ? 96.429  74.18   117.876 1 69.802  ? 597 PRO A CD  1 
ATOM   1208 N N   . ARG A 1 160 ? 93.569  75.234  115.783 1 70.749  ? 598 ARG A N   1 
ATOM   1209 C CA  . ARG A 1 160 ? 92.337  75.855  115.321 1 71.959  ? 598 ARG A CA  1 
ATOM   1210 C C   . ARG A 1 160 ? 92.424  77.359  115.519 1 70.916  ? 598 ARG A C   1 
ATOM   1211 O O   . ARG A 1 160 ? 93.179  77.835  116.361 1 77.872  ? 598 ARG A O   1 
ATOM   1212 C CB  . ARG A 1 160 ? 91.125  75.32   116.1   1 76.15   ? 598 ARG A CB  1 
ATOM   1213 C CG  . ARG A 1 160 ? 90.669  73.931  115.689 1 83.712  ? 598 ARG A CG  1 
ATOM   1214 C CD  . ARG A 1 160 ? 89.543  73.447  116.567 1 98.745  ? 598 ARG A CD  1 
ATOM   1215 N NE  . ARG A 1 160 ? 89.898  73.613  117.977 1 107.141 ? 598 ARG A NE  1 
ATOM   1216 C CZ  . ARG A 1 160 ? 89.084  74.081  118.917 1 124.458 ? 598 ARG A CZ  1 
ATOM   1217 N NH1 . ARG A 1 160 ? 87.825  74.378  118.627 1 132.598 ? 598 ARG A NH1 1 
ATOM   1218 N NH2 . ARG A 1 160 ? 89.533  74.232  120.154 1 114.372 ? 598 ARG A NH2 1 
ATOM   1219 N N   . ALA A 1 161 ? 91.646  78.108  114.738 1 68.573  ? 599 ALA A N   1 
ATOM   1220 C CA  . ALA A 1 161 ? 91.625  79.555  114.855 1 73.151  ? 599 ALA A CA  1 
ATOM   1221 C C   . ALA A 1 161 ? 91.074  79.999  116.213 1 72.347  ? 599 ALA A C   1 
ATOM   1222 O O   . ALA A 1 161 ? 91.459  81.041  116.733 1 72.005  ? 599 ALA A O   1 
ATOM   1223 C CB  . ALA A 1 161 ? 90.845  80.167  113.725 1 73.444  ? 599 ALA A CB  1 
ATOM   1224 N N   . CYS A 1 162 ? 90.221  79.188  116.818 1 67.64   ? 600 CYS A N   1 
ATOM   1225 C CA  . CYS A 1 162 ? 89.754  79.462  118.171 1 74.583  ? 600 CYS A CA  1 
ATOM   1226 C C   . CYS A 1 162 ? 90.901  79.401  119.181 1 69.955  ? 600 CYS A C   1 
ATOM   1227 O O   . CYS A 1 162 ? 90.971  80.225  120.094 1 73.372  ? 600 CYS A O   1 
ATOM   1228 C CB  . CYS A 1 162 ? 88.642  78.485  118.55  1 82.99   ? 600 CYS A CB  1 
ATOM   1229 S SG  . CYS A 1 162 ? 87.096  78.914  117.704 1 104.406 ? 600 CYS A SG  1 
ATOM   1230 N N   . ASP A 1 163 ? 91.815  78.44   119.003 1 70.123  ? 601 ASP A N   1 
ATOM   1231 C CA  . ASP A 1 163 ? 93      78.351  119.846 1 71.013  ? 601 ASP A CA  1 
ATOM   1232 C C   . ASP A 1 163 ? 93.91   79.559  119.649 1 73.507  ? 601 ASP A C   1 
ATOM   1233 O O   . ASP A 1 163 ? 94.502  80.078  120.599 1 75.248  ? 601 ASP A O   1 
ATOM   1234 C CB  . ASP A 1 163 ? 93.727  77.055  119.577 1 76.089  ? 601 ASP A CB  1 
ATOM   1235 C CG  . ASP A 1 163 ? 92.855  75.841  119.828 1 90.721  ? 601 ASP A CG  1 
ATOM   1236 O OD1 . ASP A 1 163 ? 92.132  75.849  120.853 1 105.717 ? 601 ASP A OD1 1 
ATOM   1237 O OD2 . ASP A 1 163 ? 92.92   74.896  119.028 1 101.895 ? 601 ASP A OD2 1 
ATOM   1238 N N   . SER A 1 164 ? 94.027  80.014  118.398 1 69.584  ? 602 SER A N   1 
ATOM   1239 C CA  . SER A 1 164 ? 94.823  81.198  118.135 1 71.676  ? 602 SER A CA  1 
ATOM   1240 C C   . SER A 1 164 ? 94.224  82.393  118.857 1 69.586  ? 602 SER A C   1 
ATOM   1241 O O   . SER A 1 164 ? 94.97   83.231  119.39  1 65.767  ? 602 SER A O   1 
ATOM   1242 C CB  . SER A 1 164 ? 94.958  81.456  116.659 1 73.947  ? 602 SER A CB  1 
ATOM   1243 O OG  . SER A 1 164 ? 95.412  80.275  116.024 1 87.27   ? 602 SER A OG  1 
ATOM   1244 N N   . ALA A 1 165 ? 92.885  82.502  118.818 1 65.261  ? 603 ALA A N   1 
ATOM   1245 C CA  . ALA A 1 165 ? 92.211  83.579  119.523 1 70.645  ? 603 ALA A CA  1 
ATOM   1246 C C   . ALA A 1 165 ? 92.506  83.487  121.023 1 62.154  ? 603 ALA A C   1 
ATOM   1247 O O   . ALA A 1 165 ? 92.721  84.492  121.689 1 62.23   ? 603 ALA A O   1 
ATOM   1248 C CB  . ALA A 1 165 ? 90.732  83.538  119.24  1 71.876  ? 603 ALA A CB  1 
ATOM   1249 N N   . GLU A 1 166 ? 92.492  82.275  121.572 1 68.358  ? 604 GLU A N   1 
ATOM   1250 C CA  . GLU A 1 166 ? 92.768  82.105  122.99  1 68.978  ? 604 GLU A CA  1 
ATOM   1251 C C   . GLU A 1 166 ? 94.176  82.6    123.33  1 68.202  ? 604 GLU A C   1 
ATOM   1252 O O   . GLU A 1 166 ? 94.376  83.314  124.308 1 68.335  ? 604 GLU A O   1 
ATOM   1253 C CB  . GLU A 1 166 ? 92.608  80.649  123.392 1 66.474  ? 604 GLU A CB  1 
ATOM   1254 C CG  . GLU A 1 166 ? 92.75   80.431  124.888 1 85.627  ? 604 GLU A CG  1 
ATOM   1255 C CD  . GLU A 1 166 ? 92.716  78.965  125.292 1 96.102  ? 604 GLU A CD  1 
ATOM   1256 O OE1 . GLU A 1 166 ? 92.399  78.125  124.42  1 104.702 ? 604 GLU A OE1 1 
ATOM   1257 O OE2 . GLU A 1 166 ? 93.02   78.664  126.477 1 102.696 ? 604 GLU A OE2 1 
ATOM   1258 N N   . VAL A 1 167 ? 95.167  82.221  122.514 1 66.337  ? 605 VAL A N   1 
ATOM   1259 C CA  . VAL A 1 167 ? 96.525  82.661  122.752 1 64.369  ? 605 VAL A CA  1 
ATOM   1260 C C   . VAL A 1 167 ? 96.643  84.182  122.648 1 66.103  ? 605 VAL A C   1 
ATOM   1261 O O   . VAL A 1 167 ? 97.332  84.822  123.44  1 65.287  ? 605 VAL A O   1 
ATOM   1262 C CB  . VAL A 1 167 ? 97.507  81.964  121.806 1 69.449  ? 605 VAL A CB  1 
ATOM   1263 C CG1 . VAL A 1 167 ? 98.925  82.495  122.001 1 67.996  ? 605 VAL A CG1 1 
ATOM   1264 C CG2 . VAL A 1 167 ? 97.461  80.461  122.011 1 60.629  ? 605 VAL A CG2 1 
ATOM   1265 N N   . LYS A 1 168 ? 95.974  84.773  121.665 1 67.816  ? 606 LYS A N   1 
ATOM   1266 C CA  . LYS A 1 168 ? 96.012  86.215  121.511 1 67.846  ? 606 LYS A CA  1 
ATOM   1267 C C   . LYS A 1 168 ? 95.447  86.907  122.751 1 69.878  ? 606 LYS A C   1 
ATOM   1268 O O   . LYS A 1 168 ? 96.033  87.868  123.262 1 67.107  ? 606 LYS A O   1 
ATOM   1269 C CB  . LYS A 1 168 ? 95.262  86.622  120.239 1 63.404  ? 606 LYS A CB  1 
ATOM   1270 C CG  . LYS A 1 168 ? 95.233  88.091  119.966 1 63.086  ? 606 LYS A CG  1 
ATOM   1271 C CD  . LYS A 1 168 ? 94.295  88.483  118.839 1 72.138  ? 606 LYS A CD  1 
ATOM   1272 C CE  . LYS A 1 168 ? 94.75   89.706  118.13  1 76.07   ? 606 LYS A CE  1 
ATOM   1273 N NZ  . LYS A 1 168 ? 94.505  90.839  118.989 1 79.574  ? 606 LYS A NZ  1 
ATOM   1274 N N   . ALA A 1 169 ? 94.293  86.417  123.227 1 70.224  ? 607 ALA A N   1 
ATOM   1275 C CA  . ALA A 1 169 ? 93.658  86.975  124.414 1 64.058  ? 607 ALA A CA  1 
ATOM   1276 C C   . ALA A 1 169 ? 94.589  86.87   125.62  1 65.242  ? 607 ALA A C   1 
ATOM   1277 O O   . ALA A 1 169 ? 94.717  87.823  126.389 1 69.189  ? 607 ALA A O   1 
ATOM   1278 C CB  . ALA A 1 169 ? 92.359  86.281  124.699 1 64.041  ? 607 ALA A CB  1 
ATOM   1279 N N   . TRP A 1 170 ? 95.245  85.716  125.772 1 61.568  ? 608 TRP A N   1 
ATOM   1280 C CA  . TRP A 1 170 ? 96.138  85.5    126.896 1 63.918  ? 608 TRP A CA  1 
ATOM   1281 C C   . TRP A 1 170 ? 97.342  86.435  126.822 1 76.864  ? 608 TRP A C   1 
ATOM   1282 O O   . TRP A 1 170 ? 97.756  86.965  127.845 1 76.302  ? 608 TRP A O   1 
ATOM   1283 C CB  . TRP A 1 170 ? 96.59   84.047  126.915 1 65.195  ? 608 TRP A CB  1 
ATOM   1284 C CG  . TRP A 1 170 ? 97.409  83.68   128.115 1 82.036  ? 608 TRP A CG  1 
ATOM   1285 C CD1 . TRP A 1 170 ? 96.956  83.205  129.309 1 90.463  ? 608 TRP A CD1 1 
ATOM   1286 C CD2 . TRP A 1 170 ? 98.846  83.67   128.195 1 87.631  ? 608 TRP A CD2 1 
ATOM   1287 N NE1 . TRP A 1 170 ? 98.009  82.912  130.13  1 93.99   ? 608 TRP A NE1 1 
ATOM   1288 C CE2 . TRP A 1 170 ? 99.178  83.184  129.477 1 90.503  ? 608 TRP A CE2 1 
ATOM   1289 C CE3 . TRP A 1 170 ? 99.874  84.028  127.316 1 84.585  ? 608 TRP A CE3 1 
ATOM   1290 C CZ2 . TRP A 1 170 ? 100.496 83.058  129.903 1 87.246  ? 608 TRP A CZ2 1 
ATOM   1291 C CZ3 . TRP A 1 170 ? 101.178 83.908  127.741 1 86.617  ? 608 TRP A CZ3 1 
ATOM   1292 C CH2 . TRP A 1 170 ? 101.484 83.413  129.015 1 85.081  ? 608 TRP A CH2 1 
ATOM   1293 N N   . LEU A 1 171 ? 97.883  86.658  125.613 1 73.718  ? 609 LEU A N   1 
ATOM   1294 C CA  . LEU A 1 171 ? 98.978  87.611  125.44  1 74.243  ? 609 LEU A CA  1 
ATOM   1295 C C   . LEU A 1 171 ? 98.53   89.02   125.794 1 67.425  ? 609 LEU A C   1 
ATOM   1296 O O   . LEU A 1 171 ? 99.348  89.853  126.156 1 80.345  ? 609 LEU A O   1 
ATOM   1297 C CB  . LEU A 1 171 ? 99.549  87.572  124.025 1 65.175  ? 609 LEU A CB  1 
ATOM   1298 C CG  . LEU A 1 171 ? 100.389 86.333  123.697 1 67.612  ? 609 LEU A CG  1 
ATOM   1299 C CD1 . LEU A 1 171 ? 100.654 86.254  122.217 1 74.997  ? 609 LEU A CD1 1 
ATOM   1300 C CD2 . LEU A 1 171 ? 101.685 86.294  124.47  1 66.331  ? 609 LEU A CD2 1 
ATOM   1301 N N   . GLU A 1 172 ? 97.242  89.322  125.627 1 77.955  ? 610 GLU A N   1 
ATOM   1302 C CA  . GLU A 1 172 ? 96.76   90.678  125.861 1 76.183  ? 610 GLU A CA  1 
ATOM   1303 C C   . GLU A 1 172 ? 96.527  90.977  127.346 1 74.494  ? 610 GLU A C   1 
ATOM   1304 O O   . GLU A 1 172 ? 96.386  92.133  127.708 1 84.203  ? 610 GLU A O   1 
ATOM   1305 C CB  . GLU A 1 172 ? 95.457  90.904  125.108 1 77.072  ? 610 GLU A CB  1 
ATOM   1306 C CG  . GLU A 1 172 ? 95.599  91.87   123.944 1 95.376  ? 610 GLU A CG  1 
ATOM   1307 C CD  . GLU A 1 172 ? 94.581  91.597  122.844 1 97.267  ? 610 GLU A CD  1 
ATOM   1308 O OE1 . GLU A 1 172 ? 94.845  92.02   121.699 1 95.282  ? 610 GLU A OE1 1 
ATOM   1309 O OE2 . GLU A 1 172 ? 93.538  90.957  123.123 1 101.375 ? 610 GLU A OE2 1 
ATOM   1310 N N   . THR A 1 173 ? 96.473  89.961  128.21  1 75.676  ? 611 THR A N   1 
ATOM   1311 C CA  . THR A 1 173 ? 96.285  90.197  129.637 1 75.226  ? 611 THR A CA  1 
ATOM   1312 C C   . THR A 1 173 ? 97.604  90.627  130.275 1 80.938  ? 611 THR A C   1 
ATOM   1313 O O   . THR A 1 173 ? 98.687  90.448  129.71  1 80.296  ? 611 THR A O   1 
ATOM   1314 C CB  . THR A 1 173 ? 95.751  88.964  130.353 1 71.779  ? 611 THR A CB  1 
ATOM   1315 O OG1 . THR A 1 173 ? 96.784  87.987  130.428 1 74.818  ? 611 THR A OG1 1 
ATOM   1316 C CG2 . THR A 1 173 ? 94.568  88.342  129.643 1 78.06   ? 611 THR A CG2 1 
ATOM   1317 N N   . SER A 1 174 ? 97.505  91.204  131.475 1 85.221  ? 612 SER A N   1 
ATOM   1318 C CA  . SER A 1 174 ? 98.672  91.732  132.162 1 80.68   ? 612 SER A CA  1 
ATOM   1319 C C   . SER A 1 174 ? 99.572  90.596  132.66  1 81.586  ? 612 SER A C   1 
ATOM   1320 O O   . SER A 1 174 ? 100.797 90.722  132.62  1 78.932  ? 612 SER A O   1 
ATOM   1321 C CB  . SER A 1 174 ? 98.274  92.64   133.268 1 85.876  ? 612 SER A CB  1 
ATOM   1322 O OG  . SER A 1 174 ? 97.892  91.884  134.41  1 94.313  ? 612 SER A OG  1 
ATOM   1323 N N   . GLU A 1 175 ? 98.961  89.479  133.068 1 75.674  ? 613 GLU A N   1 
ATOM   1324 C CA  . GLU A 1 175 ? 99.713  88.361  133.613 1 81.546  ? 613 GLU A CA  1 
ATOM   1325 C C   . GLU A 1 175 ? 100.515 87.662  132.511 1 85.688  ? 613 GLU A C   1 
ATOM   1326 O O   . GLU A 1 175 ? 101.699 87.37   132.686 1 93.982  ? 613 GLU A O   1 
ATOM   1327 C CB  . GLU A 1 175 ? 98.784  87.358  134.298 1 88.321  ? 613 GLU A CB  1 
ATOM   1328 C CG  . GLU A 1 175 ? 97.838  88.004  135.308 1 105.67  ? 613 GLU A CG  1 
ATOM   1329 C CD  . GLU A 1 175 ? 96.578  88.59   134.678 1 119.417 ? 613 GLU A CD  1 
ATOM   1330 O OE1 . GLU A 1 175 ? 95.868  87.845  133.965 1 106.6   ? 613 GLU A OE1 1 
ATOM   1331 O OE2 . GLU A 1 175 ? 96.299  89.791  134.897 1 117.536 ? 613 GLU A OE2 1 
ATOM   1332 N N   . GLY A 1 176 ? 99.854  87.353  131.388 1 75.332  ? 614 GLY A N   1 
ATOM   1333 C CA  . GLY A 1 176 ? 100.521 86.724  130.26  1 75.939  ? 614 GLY A CA  1 
ATOM   1334 C C   . GLY A 1 176 ? 101.649 87.591  129.704 1 73.841  ? 614 GLY A C   1 
ATOM   1335 O O   . GLY A 1 176 ? 102.765 87.121  129.465 1 77.812  ? 614 GLY A O   1 
ATOM   1336 N N   . PHE A 1 177 ? 101.361 88.877  129.554 1 69.73   ? 615 PHE A N   1 
ATOM   1337 C CA  . PHE A 1 177 ? 102.387 89.789  129.098 1 80.719  ? 615 PHE A CA  1 
ATOM   1338 C C   . PHE A 1 177 ? 103.549 89.843  130.091 1 82.969  ? 615 PHE A C   1 
ATOM   1339 O O   . PHE A 1 177 ? 104.704 89.942  129.669 1 82.212  ? 615 PHE A O   1 
ATOM   1340 C CB  . PHE A 1 177 ? 101.865 91.195  128.85  1 69.647  ? 615 PHE A CB  1 
ATOM   1341 C CG  . PHE A 1 177 ? 102.952 92.116  128.327 1 73.728  ? 615 PHE A CG  1 
ATOM   1342 C CD1 . PHE A 1 177 ? 103.385 92.063  127.002 1 85.496  ? 615 PHE A CD1 1 
ATOM   1343 C CD2 . PHE A 1 177 ? 103.567 93.013  129.179 1 79.152  ? 615 PHE A CD2 1 
ATOM   1344 C CE1 . PHE A 1 177 ? 104.366 92.933  126.538 1 82.862  ? 615 PHE A CE1 1 
ATOM   1345 C CE2 . PHE A 1 177 ? 104.559 93.862  128.72  1 78.21   ? 615 PHE A CE2 1 
ATOM   1346 C CZ  . PHE A 1 177 ? 104.963 93.813  127.398 1 82.495  ? 615 PHE A CZ  1 
ATOM   1347 N N   . ALA A 1 178 ? 103.257 89.785  131.394 1 77.195  ? 616 ALA A N   1 
ATOM   1348 C CA  . ALA A 1 178 ? 104.317 89.816  132.397 1 73.981  ? 616 ALA A CA  1 
ATOM   1349 C C   . ALA A 1 178 ? 105.228 88.596  132.265 1 68.847  ? 616 ALA A C   1 
ATOM   1350 O O   . ALA A 1 178 ? 106.448 88.717  132.297 1 79.867  ? 616 ALA A O   1 
ATOM   1351 C CB  . ALA A 1 178 ? 103.738 89.923  133.779 1 72.004  ? 616 ALA A CB  1 
ATOM   1352 N N   . VAL A 1 179 ? 104.632 87.424  132.082 1 66.863  ? 617 VAL A N   1 
ATOM   1353 C CA  . VAL A 1 179 ? 105.41  86.206  131.96  1 72.786  ? 617 VAL A CA  1 
ATOM   1354 C C   . VAL A 1 179 ? 106.304 86.283  130.721 1 75.353  ? 617 VAL A C   1 
ATOM   1355 O O   . VAL A 1 179 ? 107.487 85.962  130.775 1 81.347  ? 617 VAL A O   1 
ATOM   1356 C CB  . VAL A 1 179 ? 104.47  84.984  131.915 1 77.098  ? 617 VAL A CB  1 
ATOM   1357 C CG1 . VAL A 1 179 ? 105.16  83.752  131.361 1 82.854  ? 617 VAL A CG1 1 
ATOM   1358 C CG2 . VAL A 1 179 ? 103.91  84.685  133.29  1 81.572  ? 617 VAL A CG2 1 
ATOM   1359 N N   . ILE A 1 180 ? 105.724 86.702  129.594 1 76.842  ? 618 ILE A N   1 
ATOM   1360 C CA  . ILE A 1 180 ? 106.459 86.773  128.344 1 73.524  ? 618 ILE A CA  1 
ATOM   1361 C C   . ILE A 1 180 ? 107.567 87.822  128.459 1 72.458  ? 618 ILE A C   1 
ATOM   1362 O O   . ILE A 1 180 ? 108.676 87.602  127.985 1 66.12   ? 618 ILE A O   1 
ATOM   1363 C CB  . ILE A 1 180 ? 105.498 87.075  127.176 1 79.915  ? 618 ILE A CB  1 
ATOM   1364 C CG1 . ILE A 1 180 ? 104.509 85.958  126.96  1 73.421  ? 618 ILE A CG1 1 
ATOM   1365 C CG2 . ILE A 1 180 ? 106.247 87.393  125.888 1 72.677  ? 618 ILE A CG2 1 
ATOM   1366 C CD1 . ILE A 1 180 ? 105.141 84.597  126.847 1 80.21   ? 618 ILE A CD1 1 
ATOM   1367 N N   . LYS A 1 181 ? 107.258 88.959  129.077 1 66.953  ? 619 LYS A N   1 
ATOM   1368 C CA  . LYS A 1 181 ? 108.245 90.005  129.265 1 70.233  ? 619 LYS A CA  1 
ATOM   1369 C C   . LYS A 1 181 ? 109.423 89.503  130.11  1 81.451  ? 619 LYS A C   1 
ATOM   1370 O O   . LYS A 1 181 ? 110.573 89.801  129.806 1 83.017  ? 619 LYS A O   1 
ATOM   1371 C CB  . LYS A 1 181 ? 107.591 91.222  129.91  1 69.029  ? 619 LYS A CB  1 
ATOM   1372 C CG  . LYS A 1 181 ? 108.551 92.326  130.251 1 73.833  ? 619 LYS A CG  1 
ATOM   1373 C CD  . LYS A 1 181 ? 107.858 93.659  130.463 1 78.127  ? 619 LYS A CD  1 
ATOM   1374 C CE  . LYS A 1 181 ? 108.76  94.746  130.932 1 86.258  ? 619 LYS A CE  1 
ATOM   1375 N NZ  . LYS A 1 181 ? 109.891 94.954  130.017 1 89.252  ? 619 LYS A NZ  1 
ATOM   1376 N N   . GLU A 1 182 ? 109.152 88.751  131.171 1 73.613  ? 620 GLU A N   1 
ATOM   1377 C CA  . GLU A 1 182 ? 110.227 88.235  132.004 1 83.226  ? 620 GLU A CA  1 
ATOM   1378 C C   . GLU A 1 182 ? 111.127 87.295  131.203 1 77.309  ? 620 GLU A C   1 
ATOM   1379 O O   . GLU A 1 182 ? 112.351 87.433  131.212 1 86.019  ? 620 GLU A O   1 
ATOM   1380 C CB  . GLU A 1 182 ? 109.647 87.538  133.233 1 81.31   ? 620 GLU A CB  1 
ATOM   1381 C CG  . GLU A 1 182 ? 110.584 86.485  133.799 1 95.657  ? 620 GLU A CG  1 
ATOM   1382 C CD  . GLU A 1 182 ? 110.278 86.128  135.245 1 116.269 ? 620 GLU A CD  1 
ATOM   1383 O OE1 . GLU A 1 182 ? 109.08  86.037  135.616 1 112.677 ? 620 GLU A OE1 1 
ATOM   1384 O OE2 . GLU A 1 182 ? 111.256 85.893  135.997 1 132.97  ? 620 GLU A OE2 1 
ATOM   1385 N N   . ALA A 1 183 ? 110.509 86.343  130.504 1 72.38   ? 621 ALA A N   1 
ATOM   1386 C CA  . ALA A 1 183 ? 111.266 85.402  129.69  1 67.384  ? 621 ALA A CA  1 
ATOM   1387 C C   . ALA A 1 183 ? 112.115 86.142  128.65  1 79.863  ? 621 ALA A C   1 
ATOM   1388 O O   . ALA A 1 183 ? 113.276 85.818  128.443 1 88.706  ? 621 ALA A O   1 
ATOM   1389 C CB  . ALA A 1 183 ? 110.339 84.407  129.034 1 67.086  ? 621 ALA A CB  1 
ATOM   1390 N N   . PHE A 1 184 ? 111.536 87.143  127.989 1 69.854  ? 622 PHE A N   1 
ATOM   1391 C CA  . PHE A 1 184 ? 112.232 87.864  126.945 1 69.793  ? 622 PHE A CA  1 
ATOM   1392 C C   . PHE A 1 184 ? 113.393 88.66   127.532 1 75.138  ? 622 PHE A C   1 
ATOM   1393 O O   . PHE A 1 184 ? 114.485 88.666  126.975 1 75.43   ? 622 PHE A O   1 
ATOM   1394 C CB  . PHE A 1 184 ? 111.25  88.798  126.246 1 69.286  ? 622 PHE A CB  1 
ATOM   1395 C CG  . PHE A 1 184 ? 111.846 89.607  125.118 1 67.297  ? 622 PHE A CG  1 
ATOM   1396 C CD1 . PHE A 1 184 ? 112.464 90.827  125.357 1 69.001  ? 622 PHE A CD1 1 
ATOM   1397 C CD2 . PHE A 1 184 ? 111.759 89.135  123.819 1 74.792  ? 622 PHE A CD2 1 
ATOM   1398 C CE1 . PHE A 1 184 ? 113.015 91.552  124.316 1 71.512  ? 622 PHE A CE1 1 
ATOM   1399 C CE2 . PHE A 1 184 ? 112.271 89.881  122.767 1 73.79   ? 622 PHE A CE2 1 
ATOM   1400 C CZ  . PHE A 1 184 ? 112.898 91.085  123.015 1 73.317  ? 622 PHE A CZ  1 
ATOM   1401 N N   . ASP A 1 185 ? 113.148 89.341  128.653 1 78.04   ? 623 ASP A N   1 
ATOM   1402 C CA  . ASP A 1 185 ? 114.129 90.235  129.239 1 77.41   ? 623 ASP A CA  1 
ATOM   1403 C C   . ASP A 1 185 ? 115.289 89.486  129.886 1 74.088  ? 623 ASP A C   1 
ATOM   1404 O O   . ASP A 1 185 ? 116.36  90.053  130.066 1 102.613 ? 623 ASP A O   1 
ATOM   1405 C CB  . ASP A 1 185 ? 113.476 91.177  130.225 1 81.372  ? 623 ASP A CB  1 
ATOM   1406 C CG  . ASP A 1 185 ? 112.538 92.186  129.573 1 87.401  ? 623 ASP A CG  1 
ATOM   1407 O OD1 . ASP A 1 185 ? 112.075 93.097  130.276 1 95.71   ? 623 ASP A OD1 1 
ATOM   1408 O OD2 . ASP A 1 185 ? 112.274 92.071  128.35  1 90.426  ? 623 ASP A OD2 1 
ATOM   1409 N N   . SER A 1 186 ? 115.109 88.209  130.195 1 84.16   ? 624 SER A N   1 
ATOM   1410 C CA  . SER A 1 186 ? 116.158 87.451  130.86  1 86.131  ? 624 SER A CA  1 
ATOM   1411 C C   . SER A 1 186 ? 117.369 87.207  129.951 1 91.655  ? 624 SER A C   1 
ATOM   1412 O O   . SER A 1 186 ? 118.405 86.765  130.437 1 108.783 ? 624 SER A O   1 
ATOM   1413 C CB  . SER A 1 186 ? 115.619 86.151  131.367 1 83.965  ? 624 SER A CB  1 
ATOM   1414 O OG  . SER A 1 186 ? 115.703 85.147  130.363 1 87.535  ? 624 SER A OG  1 
ATOM   1415 N N   . THR A 1 187 ? 117.262 87.474  128.642 1 82.087  ? 625 THR A N   1 
ATOM   1416 C CA  . THR A 1 187 ? 118.269 87.018  127.688 1 79.861  ? 625 THR A CA  1 
ATOM   1417 C C   . THR A 1 187 ? 119.375 88.047  127.457 1 72.32   ? 625 THR A C   1 
ATOM   1418 O O   . THR A 1 187 ? 120.365 87.733  126.802 1 76.617  ? 625 THR A O   1 
ATOM   1419 C CB  . THR A 1 187 ? 117.641 86.669  126.339 1 84.55   ? 625 THR A CB  1 
ATOM   1420 O OG1 . THR A 1 187 ? 117.039 87.854  125.822 1 79.364  ? 625 THR A OG1 1 
ATOM   1421 C CG2 . THR A 1 187 ? 116.637 85.538  126.445 1 83.116  ? 625 THR A CG2 1 
ATOM   1422 N N   . SER A 1 188 ? 119.214 89.27   127.96  1 75.243  ? 626 SER A N   1 
ATOM   1423 C CA  . SER A 1 188 ? 120.246 90.274  127.809 1 73.367  ? 626 SER A CA  1 
ATOM   1424 C C   . SER A 1 188 ? 119.891 91.496  128.647 1 80.539  ? 626 SER A C   1 
ATOM   1425 O O   . SER A 1 188 ? 118.738 91.66   129.035 1 87.878  ? 626 SER A O   1 
ATOM   1426 C CB  . SER A 1 188 ? 120.437 90.628  126.351 1 90.847  ? 626 SER A CB  1 
ATOM   1427 O OG  . SER A 1 188 ? 120.37  92.036  126.145 1 90.792  ? 626 SER A OG  1 
ATOM   1428 N N   . ARG A 1 189 ? 120.879 92.361  128.904 1 75.71   ? 627 ARG A N   1 
ATOM   1429 C CA  . ARG A 1 189 ? 120.668 93.486  129.807 1 86.957  ? 627 ARG A CA  1 
ATOM   1430 C C   . ARG A 1 189 ? 119.898 94.611  129.128 1 84.592  ? 627 ARG A C   1 
ATOM   1431 O O   . ARG A 1 189 ? 119.343 95.469  129.81  1 90.582  ? 627 ARG A O   1 
ATOM   1432 C CB  . ARG A 1 189 ? 121.971 94.084  130.347 1 95.251  ? 627 ARG A CB  1 
ATOM   1433 C CG  . ARG A 1 189 ? 122.889 94.623  129.261 1 97.386  ? 627 ARG A CG  1 
ATOM   1434 C CD  . ARG A 1 189 ? 124.266 94.977  129.783 1 111.654 ? 627 ARG A CD  1 
ATOM   1435 N NE  . ARG A 1 189 ? 124.349 96.376  130.211 1 108.561 ? 627 ARG A NE  1 
ATOM   1436 C CZ  . ARG A 1 189 ? 125.242 97.258  129.756 1 132.271 ? 627 ARG A CZ  1 
ATOM   1437 N NH1 . ARG A 1 189 ? 126.178 96.881  128.894 1 130.247 ? 627 ARG A NH1 1 
ATOM   1438 N NH2 . ARG A 1 189 ? 125.195 98.524  130.161 1 125.717 ? 627 ARG A NH2 1 
ATOM   1439 N N   . PHE A 1 190 ? 119.904 94.648  127.792 1 90.489  ? 628 PHE A N   1 
ATOM   1440 C CA  . PHE A 1 190 ? 119.171 95.68   127.068 1 88.727  ? 628 PHE A CA  1 
ATOM   1441 C C   . PHE A 1 190 ? 117.791 95.193  126.617 1 85.037  ? 628 PHE A C   1 
ATOM   1442 O O   . PHE A 1 190 ? 117.004 96.002  126.142 1 98.964  ? 628 PHE A O   1 
ATOM   1443 C CB  . PHE A 1 190 ? 119.982 96.113  125.849 1 82.074  ? 628 PHE A CB  1 
ATOM   1444 C CG  . PHE A 1 190 ? 121.31  96.744  126.212 1 86.54   ? 628 PHE A CG  1 
ATOM   1445 C CD1 . PHE A 1 190 ? 121.366 97.801  127.111 1 91.851  ? 628 PHE A CD1 1 
ATOM   1446 C CD2 . PHE A 1 190 ? 122.49  96.267  125.661 1 87.551  ? 628 PHE A CD2 1 
ATOM   1447 C CE1 . PHE A 1 190 ? 122.581 98.379  127.431 1 93.302  ? 628 PHE A CE1 1 
ATOM   1448 C CE2 . PHE A 1 190 ? 123.703 96.841  126.002 1 85.623  ? 628 PHE A CE2 1 
ATOM   1449 C CZ  . PHE A 1 190 ? 123.744 97.894  126.881 1 82.034  ? 628 PHE A CZ  1 
ATOM   1450 N N   . ALA A 1 191 ? 117.502 93.893  126.753 1 80.775  ? 629 ALA A N   1 
ATOM   1451 C CA  . ALA A 1 191 ? 116.227 93.342  126.314 1 84.054  ? 629 ALA A CA  1 
ATOM   1452 C C   . ALA A 1 191 ? 115.11  93.741  127.272 1 79.298  ? 629 ALA A C   1 
ATOM   1453 O O   . ALA A 1 191 ? 114.971 93.138  128.321 1 94.503  ? 629 ALA A O   1 
ATOM   1454 C CB  . ALA A 1 191 ? 116.321 91.849  126.206 1 75.998  ? 629 ALA A CB  1 
ATOM   1455 N N   . ARG A 1 192 ? 114.333 94.757  126.904 1 76.776  ? 630 ARG A N   1 
ATOM   1456 C CA  . ARG A 1 192 ? 113.229 95.246  127.708 1 77.371  ? 630 ARG A CA  1 
ATOM   1457 C C   . ARG A 1 192 ? 111.977 95.268  126.83  1 73.869  ? 630 ARG A C   1 
ATOM   1458 O O   . ARG A 1 192 ? 111.726 96.222  126.1   1 81.917  ? 630 ARG A O   1 
ATOM   1459 C CB  . ARG A 1 192 ? 113.533 96.631  128.288 1 81.5    ? 630 ARG A CB  1 
ATOM   1460 C CG  . ARG A 1 192 ? 114.704 96.676  129.26  1 96.674  ? 630 ARG A CG  1 
ATOM   1461 C CD  . ARG A 1 192 ? 114.605 95.614  130.355 1 102.2   ? 630 ARG A CD  1 
ATOM   1462 N NE  . ARG A 1 192 ? 115.539 95.814  131.468 1 114.366 ? 630 ARG A NE  1 
ATOM   1463 C CZ  . ARG A 1 192 ? 115.506 96.872  132.283 1 131.11  ? 630 ARG A CZ  1 
ATOM   1464 N NH1 . ARG A 1 192 ? 114.601 97.827  132.112 1 131.022 ? 630 ARG A NH1 1 
ATOM   1465 N NH2 . ARG A 1 192 ? 116.374 96.969  133.279 1 133.032 ? 630 ARG A NH2 1 
ATOM   1466 N N   . LEU A 1 193 ? 111.211 94.185  126.891 1 74.695  ? 631 LEU A N   1 
ATOM   1467 C CA  . LEU A 1 193 ? 110.051 94.018  126.037 1 73.227  ? 631 LEU A CA  1 
ATOM   1468 C C   . LEU A 1 193 ? 109.057 95.165  126.242 1 71.903  ? 631 LEU A C   1 
ATOM   1469 O O   . LEU A 1 193 ? 108.689 95.483  127.364 1 86.809  ? 631 LEU A O   1 
ATOM   1470 C CB  . LEU A 1 193 ? 109.392 92.676  126.343 1 74.439  ? 631 LEU A CB  1 
ATOM   1471 C CG  . LEU A 1 193 ? 108.347 92.175  125.34  1 73.314  ? 631 LEU A CG  1 
ATOM   1472 C CD1 . LEU A 1 193 ? 108.976 92.057  123.967 1 75.225  ? 631 LEU A CD1 1 
ATOM   1473 C CD2 . LEU A 1 193 ? 107.817 90.816  125.769 1 72.545  ? 631 LEU A CD2 1 
ATOM   1474 N N   . GLN A 1 194 ? 108.627 95.769  125.135 1 73.284  ? 632 GLN A N   1 
ATOM   1475 C CA  . GLN A 1 194 ? 107.544 96.737  125.115 1 74.341  ? 632 GLN A CA  1 
ATOM   1476 C C   . GLN A 1 194 ? 106.257 96.049  124.657 1 66.087  ? 632 GLN A C   1 
ATOM   1477 O O   . GLN A 1 194 ? 106.219 94.848  124.405 1 75.998  ? 632 GLN A O   1 
ATOM   1478 C CB  . GLN A 1 194 ? 107.902 97.873  124.168 1 72.412  ? 632 GLN A CB  1 
ATOM   1479 C CG  . GLN A 1 194 ? 109.286 98.464  124.373 1 74.869  ? 632 GLN A CG  1 
ATOM   1480 C CD  . GLN A 1 194 ? 109.646 99.466  123.283 1 81.933  ? 632 GLN A CD  1 
ATOM   1481 O OE1 . GLN A 1 194 ? 108.822 99.81   122.431 1 86.828  ? 632 GLN A OE1 1 
ATOM   1482 N NE2 . GLN A 1 194 ? 110.887 99.929  123.257 1 77.589  ? 632 GLN A NE2 1 
ATOM   1483 N N   . LYS A 1 195 ? 105.177 96.806  124.569 1 81.702  ? 633 LYS A N   1 
ATOM   1484 C CA  . LYS A 1 195 ? 103.864 96.23   124.311 1 90.165  ? 633 LYS A CA  1 
ATOM   1485 C C   . LYS A 1 195 ? 103.882 95.423  123.015 1 82.885  ? 633 LYS A C   1 
ATOM   1486 O O   . LYS A 1 195 ? 104.47  95.854  122.032 1 98.646  ? 633 LYS A O   1 
ATOM   1487 C CB  . LYS A 1 195 ? 102.792 97.322  124.226 1 90.605  ? 633 LYS A CB  1 
ATOM   1488 C CG  . LYS A 1 195 ? 102.85  98.184  122.975 1 108.773 ? 633 LYS A CG  1 
ATOM   1489 C CD  . LYS A 1 195 ? 101.714 99.202  122.853 1 118.495 ? 633 LYS A CD  1 
ATOM   1490 C CE  . LYS A 1 195 ? 101.385 99.909  124.137 1 124.935 ? 633 LYS A CE  1 
ATOM   1491 N NZ  . LYS A 1 195 ? 102.576 100.487 124.772 1 135.846 ? 633 LYS A NZ  1 
ATOM   1492 N N   . LEU A 1 196 ? 103.211 94.264  123.046 1 81.335  ? 634 LEU A N   1 
ATOM   1493 C CA  . LEU A 1 196 ? 103.158 93.343  121.926 1 73.09   ? 634 LEU A CA  1 
ATOM   1494 C C   . LEU A 1 196 ? 102.057 93.753  120.96  1 72.954  ? 634 LEU A C   1 
ATOM   1495 O O   . LEU A 1 196 ? 101.071 94.371  121.344 1 91.647  ? 634 LEU A O   1 
ATOM   1496 C CB  . LEU A 1 196 ? 102.913 91.917  122.393 1 66.97   ? 634 LEU A CB  1 
ATOM   1497 C CG  . LEU A 1 196 ? 104.102 91.166  122.98  1 76.622  ? 634 LEU A CG  1 
ATOM   1498 C CD1 . LEU A 1 196 ? 103.539 89.899  123.612 1 81.718  ? 634 LEU A CD1 1 
ATOM   1499 C CD2 . LEU A 1 196 ? 105.177 90.852  121.94  1 82.27   ? 634 LEU A CD2 1 
ATOM   1500 N N   . HIS A 1 197 ? 102.242 93.372  119.697 1 69.894  ? 635 HIS A N   1 
ATOM   1501 C CA  . HIS A 1 197 ? 101.271 93.603  118.647 1 65.482  ? 635 HIS A CA  1 
ATOM   1502 C C   . HIS A 1 197 ? 101.038 92.276  117.955 1 61.706  ? 635 HIS A C   1 
ATOM   1503 O O   . HIS A 1 197 ? 101.954 91.681  117.427 1 76.336  ? 635 HIS A O   1 
ATOM   1504 C CB  . HIS A 1 197 ? 101.72  94.723  117.705 1 75.313  ? 635 HIS A CB  1 
ATOM   1505 C CG  . HIS A 1 197 ? 100.655 95.151  116.761 1 87.236  ? 635 HIS A CG  1 
ATOM   1506 N ND1 . HIS A 1 197 ? 99.994  94.29   115.913 1 95.619  ? 635 HIS A ND1 1 
ATOM   1507 C CD2 . HIS A 1 197 ? 100.097 96.35   116.562 1 99.942  ? 635 HIS A CD2 1 
ATOM   1508 C CE1 . HIS A 1 197 ? 99.093  94.972  115.213 1 89.031  ? 635 HIS A CE1 1 
ATOM   1509 N NE2 . HIS A 1 197 ? 99.131  96.215  115.594 1 85.422  ? 635 HIS A NE2 1 
ATOM   1510 N N   . THR A 1 198 ? 99.799  91.813  117.985 1 67.059  ? 636 THR A N   1 
ATOM   1511 C CA  . THR A 1 198 ? 99.44   90.524  117.443 1 65.598  ? 636 THR A CA  1 
ATOM   1512 C C   . THR A 1 198 ? 98.517  90.721  116.252 1 62.766  ? 636 THR A C   1 
ATOM   1513 O O   . THR A 1 198 ? 97.816  91.72   116.144 1 71.326  ? 636 THR A O   1 
ATOM   1514 C CB  . THR A 1 198 ? 98.78   89.64   118.506 1 73.368  ? 636 THR A CB  1 
ATOM   1515 O OG1 . THR A 1 198 ? 97.808  90.404  119.221 1 86.128  ? 636 THR A OG1 1 
ATOM   1516 C CG2 . THR A 1 198 ? 99.81   89.084  119.467 1 78.817  ? 636 THR A CG2 1 
ATOM   1517 N N   . SER A 1 199 ? 98.506  89.717  115.377 1 64.176  ? 637 SER A N   1 
ATOM   1518 C CA  . SER A 1 199 ? 97.575  89.676  114.264 1 62.452  ? 637 SER A CA  1 
ATOM   1519 C C   . SER A 1 199 ? 97.262  88.221  113.989 1 57.416  ? 637 SER A C   1 
ATOM   1520 O O   . SER A 1 199 ? 98.152  87.404  113.895 1 64.571  ? 637 SER A O   1 
ATOM   1521 C CB  . SER A 1 199 ? 98.157  90.38   113.065 1 65.311  ? 637 SER A CB  1 
ATOM   1522 O OG  . SER A 1 199 ? 97.333  90.293  111.919 1 77.166  ? 637 SER A OG  1 
ATOM   1523 N N   . ILE A 1 200 ? 95.989  87.895  113.874 1 62.242  ? 638 ILE A N   1 
ATOM   1524 C CA  . ILE A 1 200 ? 95.572  86.55   113.561 1 60.266  ? 638 ILE A CA  1 
ATOM   1525 C C   . ILE A 1 200 ? 95.257  86.47   112.076 1 60.362  ? 638 ILE A C   1 
ATOM   1526 O O   . ILE A 1 200 ? 94.725  87.407  111.491 1 62.664  ? 638 ILE A O   1 
ATOM   1527 C CB  . ILE A 1 200 ? 94.387  86.125  114.456 1 67.102  ? 638 ILE A CB  1 
ATOM   1528 C CG1 . ILE A 1 200 ? 94.893  85.571  115.776 1 75.938  ? 638 ILE A CG1 1 
ATOM   1529 C CG2 . ILE A 1 200 ? 93.513  85.097  113.768 1 65.639  ? 638 ILE A CG2 1 
ATOM   1530 C CD1 . ILE A 1 200 ? 93.84   85.009  116.7   1 85.989  ? 638 ILE A CD1 1 
ATOM   1531 N N   . ALA A 1 201 ? 95.536  85.306  111.486 1 55.343  ? 639 ALA A N   1 
ATOM   1532 C CA  . ALA A 1 201 ? 95.007  84.95   110.186 1 62      ? 639 ALA A CA  1 
ATOM   1533 C C   . ALA A 1 201 ? 94.669  83.472  110.212 1 60.656  ? 639 ALA A C   1 
ATOM   1534 O O   . ALA A 1 201 ? 95.552  82.637  110.147 1 63.966  ? 639 ALA A O   1 
ATOM   1535 C CB  . ALA A 1 201 ? 95.989  85.281  109.087 1 67.373  ? 639 ALA A CB  1 
ATOM   1536 N N   . GLY A 1 202 ? 93.391  83.163  110.429 1 58.738  ? 640 GLY A N   1 
ATOM   1537 C CA  . GLY A 1 202 ? 92.998  81.782  110.641 1 63.821  ? 640 GLY A CA  1 
ATOM   1538 C C   . GLY A 1 202 ? 93.685  81.247  111.882 1 60.497  ? 640 GLY A C   1 
ATOM   1539 O O   . GLY A 1 202 ? 93.668  81.906  112.914 1 71.31   ? 640 GLY A O   1 
ATOM   1540 N N   . ARG A 1 203 ? 94.343  80.105  111.757 1 66.379  ? 641 ARG A N   1 
ATOM   1541 C CA  . ARG A 1 203 ? 95.066  79.538  112.875 1 76.752  ? 641 ARG A CA  1 
ATOM   1542 C C   . ARG A 1 203 ? 96.533  79.979  112.914 1 75.534  ? 641 ARG A C   1 
ATOM   1543 O O   . ARG A 1 203 ? 97.312  79.439  113.667 1 72.321  ? 641 ARG A O   1 
ATOM   1544 C CB  . ARG A 1 203 ? 94.916  78.022  112.839 1 78.535  ? 641 ARG A CB  1 
ATOM   1545 C CG  . ARG A 1 203 ? 95.538  77.331  111.652 1 74.845  ? 641 ARG A CG  1 
ATOM   1546 C CD  . ARG A 1 203 ? 94.763  76.018  111.477 1 71.343  ? 641 ARG A CD  1 
ATOM   1547 N NE  . ARG A 1 203 ? 95.539  74.954  110.83  1 86.059  ? 641 ARG A NE  1 
ATOM   1548 C CZ  . ARG A 1 203 ? 96.46   74.188  111.428 1 89.794  ? 641 ARG A CZ  1 
ATOM   1549 N NH1 . ARG A 1 203 ? 96.771  74.342  112.692 1 88.213  ? 641 ARG A NH1 1 
ATOM   1550 N NH2 . ARG A 1 203 ? 97.065  73.231  110.757 1 100.908 ? 641 ARG A NH2 1 
ATOM   1551 N N   . ASN A 1 204 ? 96.908  80.994  112.15  1 69.606  ? 642 ASN A N   1 
ATOM   1552 C CA  . ASN A 1 204 ? 98.232  81.561  112.258 1 64.549  ? 642 ASN A CA  1 
ATOM   1553 C C   . ASN A 1 204 ? 98.163  82.765  113.182 1 66.164  ? 642 ASN A C   1 
ATOM   1554 O O   . ASN A 1 204 ? 97.34   83.644  112.984 1 71.781  ? 642 ASN A O   1 
ATOM   1555 C CB  . ASN A 1 204 ? 98.76   82.033  110.906 1 65.514  ? 642 ASN A CB  1 
ATOM   1556 C CG  . ASN A 1 204 ? 99      80.889  109.961 1 66.842  ? 642 ASN A CG  1 
ATOM   1557 O OD1 . ASN A 1 204 ? 99.049  79.734  110.402 1 84.355  ? 642 ASN A OD1 1 
ATOM   1558 N ND2 . ASN A 1 204 ? 99.184  81.186  108.689 1 78.81   ? 642 ASN A ND2 1 
ATOM   1559 N N   . LEU A 1 205 ? 99.086  82.828  114.141 1 61.514  ? 643 LEU A N   1 
ATOM   1560 C CA  . LEU A 1 205 ? 99.214  83.993  114.99  1 64.211  ? 643 LEU A CA  1 
ATOM   1561 C C   . LEU A 1 205 ? 100.578 84.634  114.74  1 59.692  ? 643 LEU A C   1 
ATOM   1562 O O   . LEU A 1 205 ? 101.606 83.99   114.91  1 67.481  ? 643 LEU A O   1 
ATOM   1563 C CB  . LEU A 1 205 ? 99.028  83.55   116.444 1 64.094  ? 643 LEU A CB  1 
ATOM   1564 C CG  . LEU A 1 205 ? 99.274  84.636  117.488 1 66.229  ? 643 LEU A CG  1 
ATOM   1565 C CD1 . LEU A 1 205 ? 98.407  85.814  117.198 1 63.99   ? 643 LEU A CD1 1 
ATOM   1566 C CD2 . LEU A 1 205 ? 99.02   84.125  118.868 1 68.003  ? 643 LEU A CD2 1 
ATOM   1567 N N   . TYR A 1 206 ? 100.567 85.897  114.381 1 52.045  ? 644 TYR A N   1 
ATOM   1568 C CA  . TYR A 1 206 ? 101.771 86.656  114.118 1 57.361  ? 644 TYR A CA  1 
ATOM   1569 C C   . TYR A 1 206 ? 101.995 87.575  115.31  1 57.045  ? 644 TYR A C   1 
ATOM   1570 O O   . TYR A 1 206 ? 101.085 88.319  115.681 1 61.087  ? 644 TYR A O   1 
ATOM   1571 C CB  . TYR A 1 206 ? 101.64  87.499  112.823 1 53.826  ? 644 TYR A CB  1 
ATOM   1572 C CG  . TYR A 1 206 ? 101.483 86.642  111.583 1 62.839  ? 644 TYR A CG  1 
ATOM   1573 C CD1 . TYR A 1 206 ? 100.236 86.119  111.259 1 61.853  ? 644 TYR A CD1 1 
ATOM   1574 C CD2 . TYR A 1 206 ? 102.586 86.28   110.794 1 57.083  ? 644 TYR A CD2 1 
ATOM   1575 C CE1 . TYR A 1 206 ? 100.088 85.277  110.168 1 60.939  ? 644 TYR A CE1 1 
ATOM   1576 C CE2 . TYR A 1 206 ? 102.438 85.46   109.688 1 53.459  ? 644 TYR A CE2 1 
ATOM   1577 C CZ  . TYR A 1 206 ? 101.188 84.952  109.384 1 58.958  ? 644 TYR A CZ  1 
ATOM   1578 O OH  . TYR A 1 206 ? 101.049 84.106  108.336 1 56.922  ? 644 TYR A OH  1 
ATOM   1579 N N   . ILE A 1 207 ? 103.187 87.501  115.914 1 62.53   ? 645 ILE A N   1 
ATOM   1580 C CA  . ILE A 1 207 ? 103.47  88.269  117.119 1 61.655  ? 645 ILE A CA  1 
ATOM   1581 C C   . ILE A 1 207 ? 104.661 89.162  116.821 1 59.734  ? 645 ILE A C   1 
ATOM   1582 O O   . ILE A 1 207 ? 105.681 88.665  116.377 1 62.418  ? 645 ILE A O   1 
ATOM   1583 C CB  . ILE A 1 207 ? 103.746 87.358  118.329 1 61.67   ? 645 ILE A CB  1 
ATOM   1584 C CG1 . ILE A 1 207 ? 102.588 86.4    118.563 1 68.353  ? 645 ILE A CG1 1 
ATOM   1585 C CG2 . ILE A 1 207 ? 104.028 88.217  119.569 1 65.739  ? 645 ILE A CG2 1 
ATOM   1586 C CD1 . ILE A 1 207 ? 102.979 85.113  119.235 1 69.127  ? 645 ILE A CD1 1 
ATOM   1587 N N   . ARG A 1 208 ? 104.513 90.452  117.074 1 54.373  ? 646 ARG A N   1 
ATOM   1588 C CA  . ARG A 1 208 ? 105.563 91.422  116.846 1 62.546  ? 646 ARG A CA  1 
ATOM   1589 C C   . ARG A 1 208 ? 106.168 91.839  118.191 1 61.499  ? 646 ARG A C   1 
ATOM   1590 O O   . ARG A 1 208 ? 105.63  92.672  118.892 1 65.799  ? 646 ARG A O   1 
ATOM   1591 C CB  . ARG A 1 208 ? 104.973 92.589  116.047 1 54.168  ? 646 ARG A CB  1 
ATOM   1592 C CG  . ARG A 1 208 ? 105.98  93.543  115.417 1 63.385  ? 646 ARG A CG  1 
ATOM   1593 C CD  . ARG A 1 208 ? 105.266 94.592  114.592 1 61.725  ? 646 ARG A CD  1 
ATOM   1594 N NE  . ARG A 1 208 ? 106.155 95.358  113.729 1 59.805  ? 646 ARG A NE  1 
ATOM   1595 C CZ  . ARG A 1 208 ? 106.509 96.587  113.914 1 55.744  ? 646 ARG A CZ  1 
ATOM   1596 N NH1 . ARG A 1 208 ? 106.097 97.218  114.979 1 63.938  ? 646 ARG A NH1 1 
ATOM   1597 N NH2 . ARG A 1 208 ? 107.332 97.18   113.065 1 65.373  ? 646 ARG A NH2 1 
ATOM   1598 N N   . PHE A 1 209 ? 107.32  91.274  118.529 1 66.238  ? 647 PHE A N   1 
ATOM   1599 C CA  . PHE A 1 209 ? 108.077 91.685  119.704 1 60.612  ? 647 PHE A CA  1 
ATOM   1600 C C   . PHE A 1 209 ? 108.878 92.936  119.366 1 60.798  ? 647 PHE A C   1 
ATOM   1601 O O   . PHE A 1 209 ? 109.516 93.011  118.32  1 68.88   ? 647 PHE A O   1 
ATOM   1602 C CB  . PHE A 1 209 ? 109.063 90.591  120.11  1 61.932  ? 647 PHE A CB  1 
ATOM   1603 C CG  . PHE A 1 209 ? 108.399 89.294  120.508 1 60.709  ? 647 PHE A CG  1 
ATOM   1604 C CD1 . PHE A 1 209 ? 107.917 88.412  119.548 1 68.398  ? 647 PHE A CD1 1 
ATOM   1605 C CD2 . PHE A 1 209 ? 108.25  88.96   121.847 1 66.103  ? 647 PHE A CD2 1 
ATOM   1606 C CE1 . PHE A 1 209 ? 107.287 87.235  119.927 1 64.273  ? 647 PHE A CE1 1 
ATOM   1607 C CE2 . PHE A 1 209 ? 107.627 87.791  122.216 1 64.474  ? 647 PHE A CE2 1 
ATOM   1608 C CZ  . PHE A 1 209 ? 107.159 86.925  121.257 1 65.821  ? 647 PHE A CZ  1 
ATOM   1609 N N   . GLN A 1 210 ? 108.803 93.941  120.231 1 58.37   ? 648 GLN A N   1 
ATOM   1610 C CA  . GLN A 1 210 ? 109.553 95.164  120.057 1 62.822  ? 648 GLN A CA  1 
ATOM   1611 C C   . GLN A 1 210 ? 110.366 95.482  121.309 1 65.148  ? 648 GLN A C   1 
ATOM   1612 O O   . GLN A 1 210 ? 109.917 95.242  122.411 1 69.88   ? 648 GLN A O   1 
ATOM   1613 C CB  . GLN A 1 210 ? 108.632 96.332  119.746 1 63.158  ? 648 GLN A CB  1 
ATOM   1614 C CG  . GLN A 1 210 ? 109.391 97.63   119.522 1 71.177  ? 648 GLN A CG  1 
ATOM   1615 C CD  . GLN A 1 210 ? 108.547 98.633  118.785 1 71.894  ? 648 GLN A CD  1 
ATOM   1616 O OE1 . GLN A 1 210 ? 107.319 98.567  118.859 1 81.386  ? 648 GLN A OE1 1 
ATOM   1617 N NE2 . GLN A 1 210 ? 109.198 99.547  118.075 1 78.485  ? 648 GLN A NE2 1 
ATOM   1618 N N   . SER A 1 211 ? 111.576 96.003  121.132 1 68.797  ? 649 SER A N   1 
ATOM   1619 C CA  . SER A 1 211 ? 112.429 96.344  122.256 1 68.714  ? 649 SER A CA  1 
ATOM   1620 C C   . SER A 1 211 ? 113.594 97.226  121.829 1 67.131  ? 649 SER A C   1 
ATOM   1621 O O   . SER A 1 211 ? 114.091 97.11   120.717 1 70.154  ? 649 SER A O   1 
ATOM   1622 C CB  . SER A 1 211 ? 112.938 95.117  122.925 1 76.182  ? 649 SER A CB  1 
ATOM   1623 O OG  . SER A 1 211 ? 113.983 95.436  123.831 1 72.78   ? 649 SER A OG  1 
ATOM   1624 N N   . ARG A 1 212 ? 114.025 98.107  122.732 1 69.76   ? 650 ARG A N   1 
ATOM   1625 C CA  . ARG A 1 212 ? 115.297 98.804  122.614 1 64.976  ? 650 ARG A CA  1 
ATOM   1626 C C   . ARG A 1 212 ? 116.438 97.811  122.792 1 60.275  ? 650 ARG A C   1 
ATOM   1627 O O   . ARG A 1 212 ? 116.275 96.751  123.384 1 72.864  ? 650 ARG A O   1 
ATOM   1628 C CB  . ARG A 1 212 ? 115.387 99.886  123.685 1 70.572  ? 650 ARG A CB  1 
ATOM   1629 C CG  . ARG A 1 212 ? 114.778 101.205 123.261 1 80.732  ? 650 ARG A CG  1 
ATOM   1630 C CD  . ARG A 1 212 ? 114.037 101.839 124.378 1 96.773  ? 650 ARG A CD  1 
ATOM   1631 N NE  . ARG A 1 212 ? 113.928 103.29  124.222 1 104.983 ? 650 ARG A NE  1 
ATOM   1632 C CZ  . ARG A 1 212 ? 114.885 104.159 124.546 1 111.922 ? 650 ARG A CZ  1 
ATOM   1633 N NH1 . ARG A 1 212 ? 116.053 103.745 125.021 1 113.462 ? 650 ARG A NH1 1 
ATOM   1634 N NH2 . ARG A 1 212 ? 114.655 105.457 124.407 1 113.032 ? 650 ARG A NH2 1 
ATOM   1635 N N   . SER A 1 213 ? 117.611 98.16   122.265 1 64.854  ? 651 SER A N   1 
ATOM   1636 C CA  . SER A 1 213 ? 118.714 97.203  122.209 1 71.995  ? 651 SER A CA  1 
ATOM   1637 C C   . SER A 1 213 ? 120.056 97.878  122.455 1 68.069  ? 651 SER A C   1 
ATOM   1638 O O   . SER A 1 213 ? 121.071 97.465  121.917 1 75.857  ? 651 SER A O   1 
ATOM   1639 C CB  . SER A 1 213 ? 118.74  96.467  120.873 1 71.915  ? 651 SER A CB  1 
ATOM   1640 O OG  . SER A 1 213 ? 118.788 97.389  119.798 1 70.007  ? 651 SER A OG  1 
ATOM   1641 N N   . GLY A 1 214 ? 120.085 98.894  123.307 1 71.381  ? 652 GLY A N   1 
ATOM   1642 C CA  . GLY A 1 214 ? 121.336 99.58   123.56  1 67.674  ? 652 GLY A CA  1 
ATOM   1643 C C   . GLY A 1 214 ? 121.738 100.404 122.34  1 71.509  ? 652 GLY A C   1 
ATOM   1644 O O   . GLY A 1 214 ? 120.941 101.14  121.781 1 88.074  ? 652 GLY A O   1 
ATOM   1645 N N   . ASP A 1 215 ? 122.978 100.236 121.91  1 67.55   ? 653 ASP A N   1 
ATOM   1646 C CA  . ASP A 1 215 ? 123.506 100.927 120.751 1 68.558  ? 653 ASP A CA  1 
ATOM   1647 C C   . ASP A 1 215 ? 123.638 99.981  119.56  1 62.587  ? 653 ASP A C   1 
ATOM   1648 O O   . ASP A 1 215 ? 124.042 100.417 118.497 1 64.04   ? 653 ASP A O   1 
ATOM   1649 C CB  . ASP A 1 215 ? 124.864 101.547 121.028 1 73.062  ? 653 ASP A CB  1 
ATOM   1650 C CG  . ASP A 1 215 ? 124.768 102.844 121.812 1 68.96   ? 653 ASP A CG  1 
ATOM   1651 O OD1 . ASP A 1 215 ? 124.403 103.815 121.187 1 78.612  ? 653 ASP A OD1 1 
ATOM   1652 O OD2 . ASP A 1 215 ? 125.05  102.857 123.038 1 82.381  ? 653 ASP A OD2 1 
ATOM   1653 N N   . ALA A 1 216 ? 123.331 98.698  119.733 1 63.62   ? 654 ALA A N   1 
ATOM   1654 C CA  . ALA A 1 216 ? 123.346 97.768  118.623 1 68.788  ? 654 ALA A CA  1 
ATOM   1655 C C   . ALA A 1 216 ? 122.093 97.99   117.786 1 73.831  ? 654 ALA A C   1 
ATOM   1656 O O   . ALA A 1 216 ? 121.116 98.583  118.238 1 84.95   ? 654 ALA A O   1 
ATOM   1657 C CB  . ALA A 1 216 ? 123.423 96.355  119.116 1 66.314  ? 654 ALA A CB  1 
ATOM   1658 N N   . MET A 1 217 ? 122.132 97.52   116.546 1 74.378  ? 655 MET A N   1 
ATOM   1659 C CA  . MET A 1 217 ? 120.97  97.595  115.68  1 76.976  ? 655 MET A CA  1 
ATOM   1660 C C   . MET A 1 217 ? 119.865 96.699  116.245 1 69.935  ? 655 MET A C   1 
ATOM   1661 O O   . MET A 1 217 ? 118.71  97.087  116.227 1 66.953  ? 655 MET A O   1 
ATOM   1662 C CB  . MET A 1 217 ? 121.339 97.193  114.252 1 74.26   ? 655 MET A CB  1 
ATOM   1663 C CG  . MET A 1 217 ? 120.308 97.578  113.234 1 78.187  ? 655 MET A CG  1 
ATOM   1664 S SD  . MET A 1 217 ? 119.227 96.191  112.856 1 86.94   ? 655 MET A SD  1 
ATOM   1665 C CE  . MET A 1 217 ? 120.32  95.012  112.061 1 87.81   ? 655 MET A CE  1 
ATOM   1666 N N   . GLY A 1 218 ? 120.206 95.518  116.753 1 70.565  ? 656 GLY A N   1 
ATOM   1667 C CA  . GLY A 1 218 ? 119.292 94.814  117.637 1 70.732  ? 656 GLY A CA  1 
ATOM   1668 C C   . GLY A 1 218 ? 118.767 93.486  117.109 1 73.531  ? 656 GLY A C   1 
ATOM   1669 O O   . GLY A 1 218 ? 118.104 92.76   117.847 1 74.137  ? 656 GLY A O   1 
ATOM   1670 N N   . MET A 1 219 ? 119.009 93.165  115.837 1 79.478  ? 657 MET A N   1 
ATOM   1671 C CA  . MET A 1 219 ? 118.342 92.015  115.246 1 80.984  ? 657 MET A CA  1 
ATOM   1672 C C   . MET A 1 219 ? 118.711 90.737  115.993 1 75.773  ? 657 MET A C   1 
ATOM   1673 O O   . MET A 1 219 ? 117.837 89.922  116.314 1 78.107  ? 657 MET A O   1 
ATOM   1674 C CB  . MET A 1 219 ? 118.666 91.875  113.756 1 86.704  ? 657 MET A CB  1 
ATOM   1675 C CG  . MET A 1 219 ? 117.782 92.737  112.875 1 103.325 ? 657 MET A CG  1 
ATOM   1676 S SD  . MET A 1 219 ? 116.234 91.918  112.455 1 103.961 ? 657 MET A SD  1 
ATOM   1677 C CE  . MET A 1 219 ? 115.301 92.173  113.974 1 107.83  ? 657 MET A CE  1 
ATOM   1678 N N   . ASN A 1 220 ? 120.002 90.535  116.247 1 73.61   ? 658 ASN A N   1 
ATOM   1679 C CA  . ASN A 1 220 ? 120.44  89.306  116.889 1 77.426  ? 658 ASN A CA  1 
ATOM   1680 C C   . ASN A 1 220 ? 119.845 89.212  118.291 1 74.699  ? 658 ASN A C   1 
ATOM   1681 O O   . ASN A 1 220 ? 119.312 88.178  118.677 1 78.781  ? 658 ASN A O   1 
ATOM   1682 C CB  . ASN A 1 220 ? 121.96  89.199  116.921 1 89.065  ? 658 ASN A CB  1 
ATOM   1683 C CG  . ASN A 1 220 ? 122.52  88.835  115.565 1 111.331 ? 658 ASN A CG  1 
ATOM   1684 O OD1 . ASN A 1 220 ? 123.328 89.58   114.996 1 123.741 ? 658 ASN A OD1 1 
ATOM   1685 N ND2 . ASN A 1 220 ? 122.118 87.69   115.031 1 126.643 ? 658 ASN A ND2 1 
ATOM   1686 N N   . MET A 1 221 ? 119.92  90.31   119.046 1 71.54   ? 659 MET A N   1 
ATOM   1687 C CA  . MET A 1 221 ? 119.445 90.325  120.414 1 73.576  ? 659 MET A CA  1 
ATOM   1688 C C   . MET A 1 221 ? 117.929 90.121  120.463 1 72.509  ? 659 MET A C   1 
ATOM   1689 O O   . MET A 1 221 ? 117.425 89.343  121.263 1 67.556  ? 659 MET A O   1 
ATOM   1690 C CB  . MET A 1 221 ? 119.832 91.65   121.072 1 72.04   ? 659 MET A CB  1 
ATOM   1691 C CG  . MET A 1 221 ? 119.478 91.723  122.517 1 87.717  ? 659 MET A CG  1 
ATOM   1692 S SD  . MET A 1 221 ? 117.912 92.548  122.867 1 103.11  ? 659 MET A SD  1 
ATOM   1693 C CE  . MET A 1 221 ? 118.616 93.985  123.68  1 112.191 ? 659 MET A CE  1 
ATOM   1694 N N   . ILE A 1 222 ? 117.199 90.826  119.591 1 70.662  ? 660 ILE A N   1 
ATOM   1695 C CA  . ILE A 1 222 ? 115.756 90.707  119.563 1 75.237  ? 660 ILE A CA  1 
ATOM   1696 C C   . ILE A 1 222 ? 115.365 89.277  119.187 1 65.18   ? 660 ILE A C   1 
ATOM   1697 O O   . ILE A 1 222 ? 114.436 88.724  119.76  1 76.129  ? 660 ILE A O   1 
ATOM   1698 C CB  . ILE A 1 222 ? 115.13  91.732  118.611 1 82.473  ? 660 ILE A CB  1 
ATOM   1699 C CG1 . ILE A 1 222 ? 115.496 93.15   118.983 1 94.106  ? 660 ILE A CG1 1 
ATOM   1700 C CG2 . ILE A 1 222 ? 113.619 91.536  118.564 1 85.013  ? 660 ILE A CG2 1 
ATOM   1701 C CD1 . ILE A 1 222 ? 114.538 93.782  119.935 1 99.268  ? 660 ILE A CD1 1 
ATOM   1702 N N   . SER A 1 223 ? 116.082 88.664  118.245 1 69.424  ? 661 SER A N   1 
ATOM   1703 C CA  . SER A 1 223 ? 115.78  87.302  117.83  1 69.019  ? 661 SER A CA  1 
ATOM   1704 C C   . SER A 1 223 ? 115.994 86.326  118.979 1 73.654  ? 661 SER A C   1 
ATOM   1705 O O   . SER A 1 223 ? 115.195 85.41   119.179 1 75.761  ? 661 SER A O   1 
ATOM   1706 C CB  . SER A 1 223 ? 116.584 86.895  116.621 1 71.137  ? 661 SER A CB  1 
ATOM   1707 O OG  . SER A 1 223 ? 116.15  87.578  115.453 1 77.165  ? 661 SER A OG  1 
ATOM   1708 N N   . LYS A 1 224 ? 117.076 86.52   119.732 1 77.408  ? 662 LYS A N   1 
ATOM   1709 C CA  . LYS A 1 224 ? 117.375 85.65   120.858 1 75.726  ? 662 LYS A CA  1 
ATOM   1710 C C   . LYS A 1 224 ? 116.259 85.743  121.901 1 70.13   ? 662 LYS A C   1 
ATOM   1711 O O   . LYS A 1 224 ? 115.728 84.729  122.359 1 75.451  ? 662 LYS A O   1 
ATOM   1712 C CB  . LYS A 1 224 ? 118.723 86.061  121.456 1 82.217  ? 662 LYS A CB  1 
ATOM   1713 C CG  . LYS A 1 224 ? 119.633 84.904  121.779 1 103.095 ? 662 LYS A CG  1 
ATOM   1714 C CD  . LYS A 1 224 ? 120.213 84.274  120.516 1 117.438 ? 662 LYS A CD  1 
ATOM   1715 C CE  . LYS A 1 224 ? 120.973 83.007  120.816 1 132.409 ? 662 LYS A CE  1 
ATOM   1716 N NZ  . LYS A 1 224 ? 122.058 83.203  121.793 1 126.172 ? 662 LYS A NZ  1 
ATOM   1717 N N   . GLY A 1 225 ? 115.889 86.975  122.255 1 66.394  ? 663 GLY A N   1 
ATOM   1718 C CA  . GLY A 1 225 ? 114.807 87.207  123.2   1 67.074  ? 663 GLY A CA  1 
ATOM   1719 C C   . GLY A 1 225 ? 113.496 86.579  122.711 1 75.968  ? 663 GLY A C   1 
ATOM   1720 O O   . GLY A 1 225 ? 112.763 85.974  123.481 1 67.914  ? 663 GLY A O   1 
ATOM   1721 N N   . THR A 1 226 ? 113.216 86.724  121.408 1 72.083  ? 664 THR A N   1 
ATOM   1722 C CA  . THR A 1 226 ? 111.995 86.197  120.816 1 70.293  ? 664 THR A CA  1 
ATOM   1723 C C   . THR A 1 226 ? 111.953 84.684  120.963 1 67.831  ? 664 THR A C   1 
ATOM   1724 O O   . THR A 1 226 ? 110.904 84.104  121.248 1 72.011  ? 664 THR A O   1 
ATOM   1725 C CB  . THR A 1 226 ? 111.886 86.619  119.353 1 69.967  ? 664 THR A CB  1 
ATOM   1726 O OG1 . THR A 1 226 ? 111.695 88.028  119.329 1 62.785  ? 664 THR A OG1 1 
ATOM   1727 C CG2 . THR A 1 226 ? 110.735 85.934  118.636 1 71.848  ? 664 THR A CG2 1 
ATOM   1728 N N   . GLU A 1 227 ? 113.086 84.031  120.722 1 73.424  ? 665 GLU A N   1 
ATOM   1729 C CA  . GLU A 1 227 ? 113.141 82.583  120.825 1 76.324  ? 665 GLU A CA  1 
ATOM   1730 C C   . GLU A 1 227 ? 112.841 82.13   122.255 1 74.56   ? 665 GLU A C   1 
ATOM   1731 O O   . GLU A 1 227 ? 112.063 81.205  122.489 1 79.024  ? 665 GLU A O   1 
ATOM   1732 C CB  . GLU A 1 227 ? 114.506 82.107  120.344 1 88.194  ? 665 GLU A CB  1 
ATOM   1733 C CG  . GLU A 1 227 ? 114.541 80.63   119.976 1 107.841 ? 665 GLU A CG  1 
ATOM   1734 C CD  . GLU A 1 227 ? 115.141 80.374  118.594 1 141.389 ? 665 GLU A CD  1 
ATOM   1735 O OE1 . GLU A 1 227 ? 115.444 79.187  118.288 1 146.498 ? 665 GLU A OE1 1 
ATOM   1736 O OE2 . GLU A 1 227 ? 115.266 81.345  117.801 1 117.998 ? 665 GLU A OE2 1 
ATOM   1737 N N   . LYS A 1 228 ? 113.441 82.803  123.222 1 73.517  ? 666 LYS A N   1 
ATOM   1738 C CA  . LYS A 1 228 ? 113.219 82.459  124.616 1 76.096  ? 666 LYS A CA  1 
ATOM   1739 C C   . LYS A 1 228 ? 111.756 82.672  125.005 1 77.806  ? 666 LYS A C   1 
ATOM   1740 O O   . LYS A 1 228 ? 111.151 81.819  125.655 1 78.798  ? 666 LYS A O   1 
ATOM   1741 C CB  . LYS A 1 228 ? 114.145 83.316  125.475 1 74.685  ? 666 LYS A CB  1 
ATOM   1742 C CG  . LYS A 1 228 ? 113.951 83.174  126.951 1 85.504  ? 666 LYS A CG  1 
ATOM   1743 C CD  . LYS A 1 228 ? 114.339 81.788  127.444 1 94.528  ? 666 LYS A CD  1 
ATOM   1744 C CE  . LYS A 1 228 ? 115.67  81.345  126.944 1 113.218 ? 666 LYS A CE  1 
ATOM   1745 N NZ  . LYS A 1 228 ? 116.189 80.214  127.734 1 122.972 ? 666 LYS A NZ  1 
ATOM   1746 N N   . ALA A 1 229 ? 111.184 83.802  124.578 1 72.757  ? 667 ALA A N   1 
ATOM   1747 C CA  . ALA A 1 229 ? 109.795 84.106  124.876 1 73.818  ? 667 ALA A CA  1 
ATOM   1748 C C   . ALA A 1 229 ? 108.854 83.084  124.231 1 74.808  ? 667 ALA A C   1 
ATOM   1749 O O   . ALA A 1 229 ? 107.847 82.702  124.819 1 68.468  ? 667 ALA A O   1 
ATOM   1750 C CB  . ALA A 1 229 ? 109.466 85.505  124.428 1 71.656  ? 667 ALA A CB  1 
ATOM   1751 N N   . LEU A 1 230 ? 109.185 82.623  123.022 1 70.112  ? 668 LEU A N   1 
ATOM   1752 C CA  . LEU A 1 230 ? 108.34  81.653  122.361 1 69.016  ? 668 LEU A CA  1 
ATOM   1753 C C   . LEU A 1 230 ? 108.402 80.31   123.079 1 72.624  ? 668 LEU A C   1 
ATOM   1754 O O   . LEU A 1 230 ? 107.41  79.581  123.097 1 72.221  ? 668 LEU A O   1 
ATOM   1755 C CB  . LEU A 1 230 ? 108.698 81.525  120.882 1 71.998  ? 668 LEU A CB  1 
ATOM   1756 C CG  . LEU A 1 230 ? 108.269 82.705  120.004 1 77.425  ? 668 LEU A CG  1 
ATOM   1757 C CD1 . LEU A 1 230 ? 108.61  82.431  118.56  1 80.568  ? 668 LEU A CD1 1 
ATOM   1758 C CD2 . LEU A 1 230 ? 106.789 82.997  120.152 1 76.779  ? 668 LEU A CD2 1 
ATOM   1759 N N   . SER A 1 231 ? 109.558 79.949  123.642 1 71.157  ? 669 SER A N   1 
ATOM   1760 C CA  . SER A 1 231 ? 109.634 78.725  124.437 1 73.032  ? 669 SER A CA  1 
ATOM   1761 C C   . SER A 1 231 ? 108.722 78.834  125.658 1 71.313  ? 669 SER A C   1 
ATOM   1762 O O   . SER A 1 231 ? 107.963 77.918  125.995 1 76.518  ? 669 SER A O   1 
ATOM   1763 C CB  . SER A 1 231 ? 111.042 78.419  124.852 1 74.949  ? 669 SER A CB  1 
ATOM   1764 O OG  . SER A 1 231 ? 111.802 77.996  123.732 1 89.528  ? 669 SER A OG  1 
ATOM   1765 N N   . LYS A 1 232 ? 108.777 79.989  126.313 1 63.96   ? 670 LYS A N   1 
ATOM   1766 C CA  . LYS A 1 232 ? 107.932 80.2    127.466 1 69.023  ? 670 LYS A CA  1 
ATOM   1767 C C   . LYS A 1 232 ? 106.462 80.085  127.068 1 81.457  ? 670 LYS A C   1 
ATOM   1768 O O   . LYS A 1 232 ? 105.675 79.461  127.774 1 74.603  ? 670 LYS A O   1 
ATOM   1769 C CB  . LYS A 1 232 ? 108.239 81.553  128.11  1 72.647  ? 670 LYS A CB  1 
ATOM   1770 C CG  . LYS A 1 232 ? 107.306 81.927  129.235 1 83.066  ? 670 LYS A CG  1 
ATOM   1771 C CD  . LYS A 1 232 ? 107.258 80.896  130.351 1 85.149  ? 670 LYS A CD  1 
ATOM   1772 C CE  . LYS A 1 232 ? 108.483 80.941  131.216 1 95.691  ? 670 LYS A CE  1 
ATOM   1773 N NZ  . LYS A 1 232 ? 108.791 79.632  131.802 1 98.18   ? 670 LYS A NZ  1 
ATOM   1774 N N   . LEU A 1 233 ? 106.093 80.71   125.94  1 81.229  ? 671 LEU A N   1 
ATOM   1775 C CA  . LEU A 1 233 ? 104.722 80.661  125.452 1 77.108  ? 671 LEU A CA  1 
ATOM   1776 C C   . LEU A 1 233 ? 104.314 79.223  125.173 1 73.994  ? 671 LEU A C   1 
ATOM   1777 O O   . LEU A 1 233 ? 103.199 78.836  125.493 1 72.741  ? 671 LEU A O   1 
ATOM   1778 C CB  . LEU A 1 233 ? 104.553 81.516  124.2   1 80.935  ? 671 LEU A CB  1 
ATOM   1779 C CG  . LEU A 1 233 ? 103.134 81.637  123.644 1 78.01   ? 671 LEU A CG  1 
ATOM   1780 C CD1 . LEU A 1 233 ? 102.181 82.187  124.695 1 79.222  ? 671 LEU A CD1 1 
ATOM   1781 C CD2 . LEU A 1 233 ? 103.136 82.548  122.424 1 83.81   ? 671 LEU A CD2 1 
ATOM   1782 N N   . HIS A 1 234 ? 105.219 78.437  124.59  1 74.888  ? 672 HIS A N   1 
ATOM   1783 C CA  . HIS A 1 234 ? 104.935 77.039  124.327 1 79.392  ? 672 HIS A CA  1 
ATOM   1784 C C   . HIS A 1 234 ? 104.621 76.286  125.613 1 79.118  ? 672 HIS A C   1 
ATOM   1785 O O   . HIS A 1 234 ? 103.851 75.339  125.601 1 89.526  ? 672 HIS A O   1 
ATOM   1786 C CB  . HIS A 1 234 ? 106.103 76.356  123.623 1 78.794  ? 672 HIS A CB  1 
ATOM   1787 C CG  . HIS A 1 234 ? 105.752 75.016  123.099 1 83.001  ? 672 HIS A CG  1 
ATOM   1788 N ND1 . HIS A 1 234 ? 106.209 73.865  123.707 1 105.695 ? 672 HIS A ND1 1 
ATOM   1789 C CD2 . HIS A 1 234 ? 105.016 74.626  122.043 1 90.61   ? 672 HIS A CD2 1 
ATOM   1790 C CE1 . HIS A 1 234 ? 105.762 72.809  123.031 1 115.259 ? 672 HIS A CE1 1 
ATOM   1791 N NE2 . HIS A 1 234 ? 105.028 73.249  122.016 1 103.939 ? 672 HIS A NE2 1 
ATOM   1792 N N   . GLU A 1 235 ? 105.198 76.698  126.734 1 83.691  ? 673 GLU A N   1 
ATOM   1793 C CA  . GLU A 1 235 ? 104.923 75.997  127.982 1 84.156  ? 673 GLU A CA  1 
ATOM   1794 C C   . GLU A 1 235 ? 103.437 76.07   128.34  1 76.972  ? 673 GLU A C   1 
ATOM   1795 O O   . GLU A 1 235 ? 102.885 75.123  128.879 1 89.393  ? 673 GLU A O   1 
ATOM   1796 C CB  . GLU A 1 235 ? 105.748 76.559  129.135 1 85.86   ? 673 GLU A CB  1 
ATOM   1797 C CG  . GLU A 1 235 ? 107.227 76.219  129.011 1 92.762  ? 673 GLU A CG  1 
ATOM   1798 C CD  . GLU A 1 235 ? 108.034 76.707  130.202 1 109.092 ? 673 GLU A CD  1 
ATOM   1799 O OE1 . GLU A 1 235 ? 107.464 77.395  131.09  1 102.662 ? 673 GLU A OE1 1 
ATOM   1800 O OE2 . GLU A 1 235 ? 109.249 76.394  130.223 1 115.483 ? 673 GLU A OE2 1 
ATOM   1801 N N   . TYR A 1 236 ? 102.782 77.195  128.058 1 77.967  ? 674 TYR A N   1 
ATOM   1802 C CA  . TYR A 1 236 ? 101.38  77.347  128.413 1 78.175  ? 674 TYR A CA  1 
ATOM   1803 C C   . TYR A 1 236 ? 100.447 76.744  127.358 1 83.264  ? 674 TYR A C   1 
ATOM   1804 O O   . TYR A 1 236 ? 99.342  76.32   127.686 1 88.224  ? 674 TYR A O   1 
ATOM   1805 C CB  . TYR A 1 236 ? 101.031 78.812  128.62  1 72.145  ? 674 TYR A CB  1 
ATOM   1806 C CG  . TYR A 1 236 ? 101.572 79.393  129.912 1 84.285  ? 674 TYR A CG  1 
ATOM   1807 C CD1 . TYR A 1 236 ? 102.927 79.659  130.07  1 89.995  ? 674 TYR A CD1 1 
ATOM   1808 C CD2 . TYR A 1 236 ? 100.721 79.69   130.969 1 88.088  ? 674 TYR A CD2 1 
ATOM   1809 C CE1 . TYR A 1 236 ? 103.421 80.193  131.248 1 97.423  ? 674 TYR A CE1 1 
ATOM   1810 C CE2 . TYR A 1 236 ? 101.202 80.239  132.146 1 92.188  ? 674 TYR A CE2 1 
ATOM   1811 C CZ  . TYR A 1 236 ? 102.556 80.489  132.287 1 98.709  ? 674 TYR A CZ  1 
ATOM   1812 O OH  . TYR A 1 236 ? 103.031 81.006  133.453 1 100.061 ? 674 TYR A OH  1 
ATOM   1813 N N   . PHE A 1 237 ? 100.886 76.699  126.095 1 82.421  ? 675 PHE A N   1 
ATOM   1814 C CA  . PHE A 1 237 ? 100.089 76.155  125.01  1 75.087  ? 675 PHE A CA  1 
ATOM   1815 C C   . PHE A 1 237 ? 100.889 75.086  124.293 1 73.732  ? 675 PHE A C   1 
ATOM   1816 O O   . PHE A 1 237 ? 101.433 75.339  123.223 1 76.885  ? 675 PHE A O   1 
ATOM   1817 C CB  . PHE A 1 237 ? 99.668  77.257  124.034 1 68.897  ? 675 PHE A CB  1 
ATOM   1818 C CG  . PHE A 1 237 ? 98.86   78.349  124.701 1 67.432  ? 675 PHE A CG  1 
ATOM   1819 C CD1 . PHE A 1 237 ? 97.494  78.21   124.911 1 70.766  ? 675 PHE A CD1 1 
ATOM   1820 C CD2 . PHE A 1 237 ? 99.488  79.488  125.173 1 67.099  ? 675 PHE A CD2 1 
ATOM   1821 C CE1 . PHE A 1 237 ? 96.775  79.206  125.56  1 68.202  ? 675 PHE A CE1 1 
ATOM   1822 C CE2 . PHE A 1 237 ? 98.772  80.481  125.815 1 69.792  ? 675 PHE A CE2 1 
ATOM   1823 C CZ  . PHE A 1 237 ? 97.418  80.336  126.023 1 72.038  ? 675 PHE A CZ  1 
ATOM   1824 N N   . PRO A 1 238 ? 100.99  73.858  124.849 1 79.322  ? 676 PRO A N   1 
ATOM   1825 C CA  . PRO A 1 238 ? 101.843 72.839  124.254 1 76.419  ? 676 PRO A CA  1 
ATOM   1826 C C   . PRO A 1 238 ? 101.471 72.457  122.829 1 75.409  ? 676 PRO A C   1 
ATOM   1827 O O   . PRO A 1 238 ? 102.284 71.891  122.104 1 95.3    ? 676 PRO A O   1 
ATOM   1828 C CB  . PRO A 1 238 ? 101.738 71.658  125.211 1 76.333  ? 676 PRO A CB  1 
ATOM   1829 C CG  . PRO A 1 238 ? 100.504 71.934  126.021 1 77.799  ? 676 PRO A CG  1 
ATOM   1830 C CD  . PRO A 1 238 ? 100.331 73.408  126.085 1 75.378  ? 676 PRO A CD  1 
ATOM   1831 N N   . GLU A 1 239 ? 100.254 72.769  122.409 1 85.638  ? 677 GLU A N   1 
ATOM   1832 C CA  . GLU A 1 239 ? 99.852  72.475  121.04  1 84.972  ? 677 GLU A CA  1 
ATOM   1833 C C   . GLU A 1 239 ? 100.38  73.509  120.04  1 70.926  ? 677 GLU A C   1 
ATOM   1834 O O   . GLU A 1 239 ? 100.314 73.278  118.845 1 80.204  ? 677 GLU A O   1 
ATOM   1835 C CB  . GLU A 1 239 ? 98.333  72.441  120.937 1 87.572  ? 677 GLU A CB  1 
ATOM   1836 C CG  . GLU A 1 239 ? 97.719  71.271  121.691 1 99.865  ? 677 GLU A CG  1 
ATOM   1837 C CD  . GLU A 1 239 ? 97.84   69.979  120.913 1 126.712 ? 677 GLU A CD  1 
ATOM   1838 O OE1 . GLU A 1 239 ? 98.94   69.373  120.936 1 126.614 ? 677 GLU A OE1 1 
ATOM   1839 O OE2 . GLU A 1 239 ? 96.832  69.603  120.254 1 132.259 ? 677 GLU A OE2 1 
ATOM   1840 N N   . MET A 1 240 ? 100.923 74.623  120.505 1 69.475  ? 678 MET A N   1 
ATOM   1841 C CA  . MET A 1 240 ? 101.462 75.619  119.596 1 73.023  ? 678 MET A CA  1 
ATOM   1842 C C   . MET A 1 240 ? 102.654 75.055  118.821 1 76.328  ? 678 MET A C   1 
ATOM   1843 O O   . MET A 1 240 ? 103.474 74.317  119.363 1 81.367  ? 678 MET A O   1 
ATOM   1844 C CB  . MET A 1 240 ? 101.907 76.859  120.36  1 72.99   ? 678 MET A CB  1 
ATOM   1845 C CG  . MET A 1 240 ? 102.207 78.017  119.473 1 89.245  ? 678 MET A CG  1 
ATOM   1846 S SD  . MET A 1 240 ? 102.348 79.533  120.422 1 94.664  ? 678 MET A SD  1 
ATOM   1847 C CE  . MET A 1 240 ? 103.968 79.316  121.159 1 92.966  ? 678 MET A CE  1 
ATOM   1848 N N   . GLN A 1 241 ? 102.696 75.385  117.528 1 68.638  ? 679 GLN A N   1 
ATOM   1849 C CA  . GLN A 1 241 ? 103.807 75.062  116.654 1 73.789  ? 679 GLN A CA  1 
ATOM   1850 C C   . GLN A 1 241 ? 104.484 76.357  116.23  1 68.104  ? 679 GLN A C   1 
ATOM   1851 O O   . GLN A 1 241 ? 103.84  77.247  115.692 1 74.948  ? 679 GLN A O   1 
ATOM   1852 C CB  . GLN A 1 241 ? 103.3   74.294  115.445 1 73.712  ? 679 GLN A CB  1 
ATOM   1853 C CG  . GLN A 1 241 ? 104.36  74.037  114.383 1 97.482  ? 679 GLN A CG  1 
ATOM   1854 C CD  . GLN A 1 241 ? 103.799 73.455  113.104 1 118.3   ? 679 GLN A CD  1 
ATOM   1855 O OE1 . GLN A 1 241 ? 102.592 73.201  112.982 1 136.297 ? 679 GLN A OE1 1 
ATOM   1856 N NE2 . GLN A 1 241 ? 104.682 73.232  112.14  1 113.915 ? 679 GLN A NE2 1 
ATOM   1857 N N   . ILE A 1 242 ? 105.766 76.511  116.544 1 73.163  ? 680 ILE A N   1 
ATOM   1858 C CA  . ILE A 1 242 ? 106.497 77.675  116.072 1 73.734  ? 680 ILE A CA  1 
ATOM   1859 C C   . ILE A 1 242 ? 106.871 77.431  114.616 1 69.455  ? 680 ILE A C   1 
ATOM   1860 O O   . ILE A 1 242 ? 107.728 76.616  114.318 1 77.962  ? 680 ILE A O   1 
ATOM   1861 C CB  . ILE A 1 242 ? 107.74  77.973  116.924 1 77.122  ? 680 ILE A CB  1 
ATOM   1862 C CG1 . ILE A 1 242 ? 107.35  78.347  118.344 1 81.324  ? 680 ILE A CG1 1 
ATOM   1863 C CG2 . ILE A 1 242 ? 108.531 79.085  116.244 1 74.262  ? 680 ILE A CG2 1 
ATOM   1864 C CD1 . ILE A 1 242 ? 108.284 77.811  119.397 1 87.023  ? 680 ILE A CD1 1 
ATOM   1865 N N   . LEU A 1 243 ? 106.212 78.146  113.712 1 69.422  ? 681 LEU A N   1 
ATOM   1866 C CA  . LEU A 1 243 ? 106.383 77.906  112.29  1 70.662  ? 681 LEU A CA  1 
ATOM   1867 C C   . LEU A 1 243 ? 107.631 78.622  111.781 1 69.045  ? 681 LEU A C   1 
ATOM   1868 O O   . LEU A 1 243 ? 108.44  78.017  111.098 1 76.824  ? 681 LEU A O   1 
ATOM   1869 C CB  . LEU A 1 243 ? 105.118 78.368  111.578 1 78.861  ? 681 LEU A CB  1 
ATOM   1870 C CG  . LEU A 1 243 ? 104.906 77.922  110.13  1 85.734  ? 681 LEU A CG  1 
ATOM   1871 C CD1 . LEU A 1 243 ? 105.745 78.716  109.17  1 104.639 ? 681 LEU A CD1 1 
ATOM   1872 C CD2 . LEU A 1 243 ? 105.201 76.461  109.929 1 86.146  ? 681 LEU A CD2 1 
ATOM   1873 N N   . ALA A 1 244 ? 107.809 79.895  112.118 1 68.941  ? 682 ALA A N   1 
ATOM   1874 C CA  . ALA A 1 244 ? 109.031 80.584  111.76  1 67.856  ? 682 ALA A CA  1 
ATOM   1875 C C   . ALA A 1 244 ? 109.289 81.711  112.75  1 69.127  ? 682 ALA A C   1 
ATOM   1876 O O   . ALA A 1 244 ? 108.376 82.439  113.135 1 77.342  ? 682 ALA A O   1 
ATOM   1877 C CB  . ALA A 1 244 ? 108.95  81.156  110.331 1 69.277  ? 682 ALA A CB  1 
ATOM   1878 N N   . VAL A 1 245 ? 110.561 81.881  113.092 1 62.012  ? 683 VAL A N   1 
ATOM   1879 C CA  . VAL A 1 245 ? 110.976 82.906  114.022 1 68.933  ? 683 VAL A CA  1 
ATOM   1880 C C   . VAL A 1 245 ? 110.779 84.279  113.392 1 61.881  ? 683 VAL A C   1 
ATOM   1881 O O   . VAL A 1 245 ? 110.549 85.256  114.101 1 68.807  ? 683 VAL A O   1 
ATOM   1882 C CB  . VAL A 1 245 ? 112.414 82.691  114.513 1 74.674  ? 683 VAL A CB  1 
ATOM   1883 C CG1 . VAL A 1 245 ? 112.846 83.819  115.424 1 81.843  ? 683 VAL A CG1 1 
ATOM   1884 C CG2 . VAL A 1 245 ? 112.509 81.394  115.295 1 80.632  ? 683 VAL A CG2 1 
ATOM   1885 N N   . SER A 1 246 ? 110.808 84.332  112.064 1 64.701  ? 684 SER A N   1 
ATOM   1886 C CA  . SER A 1 246 ? 110.367 85.514  111.337 1 66.166  ? 684 SER A CA  1 
ATOM   1887 C C   . SER A 1 246 ? 109.217 85.141  110.4   1 65.719  ? 684 SER A C   1 
ATOM   1888 O O   . SER A 1 246 ? 109.358 84.26   109.553 1 64.427  ? 684 SER A O   1 
ATOM   1889 C CB  . SER A 1 246 ? 111.511 86.128  110.585 1 69.764  ? 684 SER A CB  1 
ATOM   1890 O OG  . SER A 1 246 ? 111.052 87.16   109.727 1 70.183  ? 684 SER A OG  1 
ATOM   1891 N N   . GLY A 1 247 ? 108.077 85.81   110.565 1 63.248  ? 685 GLY A N   1 
ATOM   1892 C CA  . GLY A 1 247 ? 106.905 85.575  109.731 1 61.984  ? 685 GLY A CA  1 
ATOM   1893 C C   . GLY A 1 247 ? 106.656 86.755  108.799 1 59.237  ? 685 GLY A C   1 
ATOM   1894 O O   . GLY A 1 247 ? 105.528 86.985  108.395 1 68.285  ? 685 GLY A O   1 
ATOM   1895 N N   . ASN A 1 248 ? 107.685 87.547  108.507 1 59.367  ? 686 ASN A N   1 
ATOM   1896 C CA  . ASN A 1 248 ? 107.544 88.748  107.697 1 56.072  ? 686 ASN A CA  1 
ATOM   1897 C C   . ASN A 1 248 ? 106.62  89.739  108.354 1 58.403  ? 686 ASN A C   1 
ATOM   1898 O O   . ASN A 1 248 ? 106.156 90.672  107.704 1 61.132  ? 686 ASN A O   1 
ATOM   1899 C CB  . ASN A 1 248 ? 107.088 88.507  106.267 1 58.318  ? 686 ASN A CB  1 
ATOM   1900 C CG  . ASN A 1 248 ? 108.16  87.869  105.422 1 62.158  ? 686 ASN A CG  1 
ATOM   1901 O OD1 . ASN A 1 248 ? 109.266 87.588  105.915 1 74.333  ? 686 ASN A OD1 1 
ATOM   1902 N ND2 . ASN A 1 248 ? 107.836 87.624  104.158 1 62.983  ? 686 ASN A ND2 1 
ATOM   1903 N N   . TYR A 1 249 ? 106.463 89.616  109.671 1 64.529  ? 687 TYR A N   1 
ATOM   1904 C CA  . TYR A 1 249 ? 105.616 90.55   110.391 1 61.747  ? 687 TYR A CA  1 
ATOM   1905 C C   . TYR A 1 249 ? 106.445 91.597  111.149 1 62.156  ? 687 TYR A C   1 
ATOM   1906 O O   . TYR A 1 249 ? 105.872 92.385  111.888 1 68.448  ? 687 TYR A O   1 
ATOM   1907 C CB  . TYR A 1 249 ? 104.718 89.705  111.299 1 68.87   ? 687 TYR A CB  1 
ATOM   1908 C CG  . TYR A 1 249 ? 103.537 90.473  111.843 1 63.262  ? 687 TYR A CG  1 
ATOM   1909 C CD1 . TYR A 1 249 ? 102.632 91.084  110.977 1 72.334  ? 687 TYR A CD1 1 
ATOM   1910 C CD2 . TYR A 1 249 ? 103.376 90.639  113.212 1 67.356  ? 687 TYR A CD2 1 
ATOM   1911 C CE1 . TYR A 1 249 ? 101.557 91.811  111.455 1 69.699  ? 687 TYR A CE1 1 
ATOM   1912 C CE2 . TYR A 1 249 ? 102.298 91.35   113.712 1 70.6    ? 687 TYR A CE2 1 
ATOM   1913 C CZ  . TYR A 1 249 ? 101.401 91.933  112.827 1 74.659  ? 687 TYR A CZ  1 
ATOM   1914 O OH  . TYR A 1 249 ? 100.35  92.626  113.307 1 74.549  ? 687 TYR A OH  1 
ATOM   1915 N N   . CYS A 1 250 ? 107.771 91.611  110.975 1 64.643  ? 688 CYS A N   1 
ATOM   1916 C CA  . CYS A 1 250 ? 108.66  92.51   111.709 1 65.092  ? 688 CYS A CA  1 
ATOM   1917 C C   . CYS A 1 250 ? 108.441 93.977  111.33  1 60.897  ? 688 CYS A C   1 
ATOM   1918 O O   . CYS A 1 250 ? 108.106 94.781  112.188 1 66.429  ? 688 CYS A O   1 
ATOM   1919 C CB  . CYS A 1 250 ? 110.137 92.138  111.556 1 62.326  ? 688 CYS A CB  1 
ATOM   1920 S SG  . CYS A 1 250 ? 110.308 90.337  111.324 1 67.345  ? 688 CYS A SG  1 
ATOM   1921 N N   . THR A 1 251 ? 108.576 94.377  110.057 1 60.23   ? 689 THR A N   1 
ATOM   1922 C CA  . THR A 1 251 ? 108.97  93.573  108.91  1 66.876  ? 689 THR A CA  1 
ATOM   1923 C C   . THR A 1 251 ? 110.399 94.007  108.538 1 63.774  ? 689 THR A C   1 
ATOM   1924 O O   . THR A 1 251 ? 110.72  95.184  108.456 1 62.027  ? 689 THR A O   1 
ATOM   1925 C CB  . THR A 1 251 ? 108.02  93.808  107.724 1 71.624  ? 689 THR A CB  1 
ATOM   1926 O OG1 . THR A 1 251 ? 106.737 93.269  107.996 1 66.874  ? 689 THR A OG1 1 
ATOM   1927 C CG2 . THR A 1 251 ? 108.49  93.12   106.458 1 69.904  ? 689 THR A CG2 1 
ATOM   1928 N N   . ASP A 1 252 ? 111.239 93.023  108.309 1 67.044  ? 690 ASP A N   1 
ATOM   1929 C CA  . ASP A 1 252 ? 112.644 93.251  108.066 1 65.422  ? 690 ASP A CA  1 
ATOM   1930 C C   . ASP A 1 252 ? 112.969 93.179  106.563 1 59.899  ? 690 ASP A C   1 
ATOM   1931 O O   . ASP A 1 252 ? 112.752 92.16   105.917 1 63.902  ? 690 ASP A O   1 
ATOM   1932 C CB  . ASP A 1 252 ? 113.445 92.186  108.79  1 65.524  ? 690 ASP A CB  1 
ATOM   1933 C CG  . ASP A 1 252 ? 114.934 92.456  108.721 1 73.494  ? 690 ASP A CG  1 
ATOM   1934 O OD1 . ASP A 1 252 ? 115.315 93.646  108.724 1 62.879  ? 690 ASP A OD1 1 
ATOM   1935 O OD2 . ASP A 1 252 ? 115.686 91.473  108.707 1 96.965  ? 690 ASP A OD2 1 
ATOM   1936 N N   . LYS A 1 253 ? 113.469 94.287  106.011 1 61.351  ? 691 LYS A N   1 
ATOM   1937 C CA  . LYS A 1 253 ? 114.04  94.336  104.666 1 72.965  ? 691 LYS A CA  1 
ATOM   1938 C C   . LYS A 1 253 ? 113.022 94.039  103.569 1 71.328  ? 691 LYS A C   1 
ATOM   1939 O O   . LYS A 1 253 ? 113.335 93.411  102.569 1 68.838  ? 691 LYS A O   1 
ATOM   1940 C CB  . LYS A 1 253 ? 115.227 93.373  104.584 1 62.688  ? 691 LYS A CB  1 
ATOM   1941 C CG  . LYS A 1 253 ? 116.431 93.895  105.351 1 66.617  ? 691 LYS A CG  1 
ATOM   1942 C CD  . LYS A 1 253 ? 117.515 92.835  105.397 1 64.571  ? 691 LYS A CD  1 
ATOM   1943 C CE  . LYS A 1 253 ? 118.649 93.233  106.263 1 63.235  ? 691 LYS A CE  1 
ATOM   1944 N NZ  . LYS A 1 253 ? 119.546 92.085  106.452 1 70.942  ? 691 LYS A NZ  1 
ATOM   1945 N N   . LYS A 1 254 ? 111.785 94.453  103.787 1 73.951  ? 692 LYS A N   1 
ATOM   1946 C CA  . LYS A 1 254 ? 110.763 94.419  102.758 1 63.199  ? 692 LYS A CA  1 
ATOM   1947 C C   . LYS A 1 254 ? 109.91  95.656  102.971 1 63.826  ? 692 LYS A C   1 
ATOM   1948 O O   . LYS A 1 254 ? 109.791 96.136  104.103 1 78.955  ? 692 LYS A O   1 
ATOM   1949 C CB  . LYS A 1 254 ? 109.879 93.181  102.855 1 68.275  ? 692 LYS A CB  1 
ATOM   1950 C CG  . LYS A 1 254 ? 110.368 91.943  102.172 1 60.012  ? 692 LYS A CG  1 
ATOM   1951 C CD  . LYS A 1 254 ? 111.24  91.012  103.015 1 65.303  ? 692 LYS A CD  1 
ATOM   1952 C CE  . LYS A 1 254 ? 110.505 90.451  104.155 1 69.483  ? 692 LYS A CE  1 
ATOM   1953 N NZ  . LYS A 1 254 ? 111.301 89.55   104.988 1 59.691  ? 692 LYS A NZ  1 
ATOM   1954 N N   . PRO A 1 255 ? 109.322 96.234  101.903 1 66.838  ? 693 PRO A N   1 
ATOM   1955 C CA  . PRO A 1 255 ? 108.34  97.293  102.095 1 66.537  ? 693 PRO A CA  1 
ATOM   1956 C C   . PRO A 1 255 ? 107.105 96.722  102.789 1 67.883  ? 693 PRO A C   1 
ATOM   1957 O O   . PRO A 1 255 ? 106.565 95.692  102.359 1 65.746  ? 693 PRO A O   1 
ATOM   1958 C CB  . PRO A 1 255 ? 108.095 97.79   100.675 1 63.452  ? 693 PRO A CB  1 
ATOM   1959 C CG  . PRO A 1 255 ? 108.367 96.562  99.816  1 62.172  ? 693 PRO A CG  1 
ATOM   1960 C CD  . PRO A 1 255 ? 109.503 95.855  100.487 1 62.357  ? 693 PRO A CD  1 
ATOM   1961 N N   . ALA A 1 256 ? 106.685 97.369  103.873 1 59.933  ? 694 ALA A N   1 
ATOM   1962 C CA  . ALA A 1 256 ? 105.501 96.936  104.599 1 62.343  ? 694 ALA A CA  1 
ATOM   1963 C C   . ALA A 1 256 ? 104.842 98.148  105.243 1 59.288  ? 694 ALA A C   1 
ATOM   1964 O O   . ALA A 1 256 ? 105.515 98.987  105.818 1 63.911  ? 694 ALA A O   1 
ATOM   1965 C CB  . ALA A 1 256 ? 105.857 95.898  105.633 1 63.447  ? 694 ALA A CB  1 
ATOM   1966 N N   . ALA A 1 257 ? 103.519 98.212  105.18  1 57.96   ? 695 ALA A N   1 
ATOM   1967 C CA  . ALA A 1 257 ? 102.778 99.277  105.824 1 62.045  ? 695 ALA A CA  1 
ATOM   1968 C C   . ALA A 1 257 ? 102.953 99.238  107.343 1 58.906  ? 695 ALA A C   1 
ATOM   1969 O O   . ALA A 1 257 ? 102.832 100.282 107.992 1 56.083  ? 695 ALA A O   1 
ATOM   1970 C CB  . ALA A 1 257 ? 101.314 99.165  105.442 1 60.214  ? 695 ALA A CB  1 
ATOM   1971 N N   . ILE A 1 258 ? 103.199 98.048  107.912 1 56.578  ? 696 ILE A N   1 
ATOM   1972 C CA  . ILE A 1 258 ? 103.355 97.95   109.354 1 60.981  ? 696 ILE A CA  1 
ATOM   1973 C C   . ILE A 1 258 ? 104.537 98.781  109.887 1 60.609  ? 696 ILE A C   1 
ATOM   1974 O O   . ILE A 1 258 ? 104.412 99.439  110.911 1 59.385  ? 696 ILE A O   1 
ATOM   1975 C CB  . ILE A 1 258 ? 103.436 96.501  109.827 1 60.977  ? 696 ILE A CB  1 
ATOM   1976 C CG1 . ILE A 1 258 ? 103.16  96.466  111.331 1 60.138  ? 696 ILE A CG1 1 
ATOM   1977 C CG2 . ILE A 1 258 ? 104.754 95.823  109.44  1 64.391  ? 696 ILE A CG2 1 
ATOM   1978 C CD1 . ILE A 1 258 ? 102.715 95.114  111.842 1 59.002  ? 696 ILE A CD1 1 
ATOM   1979 N N   . ASN A 1 259 ? 105.657 98.799  109.184 1 60.823  ? 697 ASN A N   1 
ATOM   1980 C CA  . ASN A 1 259 ? 106.781 99.645  109.564 1 58.87   ? 697 ASN A CA  1 
ATOM   1981 C C   . ASN A 1 259 ? 106.416 101.112 109.464 1 55.751  ? 697 ASN A C   1 
ATOM   1982 O O   . ASN A 1 259 ? 106.774 101.905 110.313 1 60.405  ? 697 ASN A O   1 
ATOM   1983 C CB  . ASN A 1 259 ? 108.044 99.337  108.764 1 60.356  ? 697 ASN A CB  1 
ATOM   1984 C CG  . ASN A 1 259 ? 108.537 97.923  108.947 1 56.479  ? 697 ASN A CG  1 
ATOM   1985 O OD1 . ASN A 1 259 ? 108.18  97.225  109.903 1 65.851  ? 697 ASN A OD1 1 
ATOM   1986 N ND2 . ASN A 1 259 ? 109.265 97.417  107.973 1 67.976  ? 697 ASN A ND2 1 
ATOM   1987 N N   . TRP A 1 260 ? 105.657 101.479 108.441 1 62.201  ? 698 TRP A N   1 
ATOM   1988 C CA  . TRP A 1 260 ? 105.242 102.856 108.274 1 54.203  ? 698 TRP A CA  1 
ATOM   1989 C C   . TRP A 1 260 ? 104.316 103.321 109.393 1 56.936  ? 698 TRP A C   1 
ATOM   1990 O O   . TRP A 1 260 ? 104.431 104.429 109.882 1 59.34   ? 698 TRP A O   1 
ATOM   1991 C CB  . TRP A 1 260 ? 104.564 102.972 106.917 1 58.437  ? 698 TRP A CB  1 
ATOM   1992 C CG  . TRP A 1 260 ? 104.07  104.343 106.585 1 56.815  ? 698 TRP A CG  1 
ATOM   1993 C CD1 . TRP A 1 260 ? 102.768 104.736 106.469 1 56.958  ? 698 TRP A CD1 1 
ATOM   1994 C CD2 . TRP A 1 260 ? 104.879 105.487 106.289 1 60.86   ? 698 TRP A CD2 1 
ATOM   1995 N NE1 . TRP A 1 260 ? 102.714 106.049 106.081 1 57.654  ? 698 TRP A NE1 1 
ATOM   1996 C CE2 . TRP A 1 260 ? 103.986 106.54  105.974 1 56.064  ? 698 TRP A CE2 1 
ATOM   1997 C CE3 . TRP A 1 260 ? 106.252 105.736 106.259 1 59.389  ? 698 TRP A CE3 1 
ATOM   1998 C CZ2 . TRP A 1 260 ? 104.438 107.811 105.655 1 59.542  ? 698 TRP A CZ2 1 
ATOM   1999 C CZ3 . TRP A 1 260 ? 106.698 106.993 105.907 1 56.27   ? 698 TRP A CZ3 1 
ATOM   2000 C CH2 . TRP A 1 260 ? 105.805 108.012 105.626 1 64.223  ? 698 TRP A CH2 1 
ATOM   2001 N N   . ILE A 1 261 ? 103.397 102.459 109.81  1 61.077  ? 699 ILE A N   1 
ATOM   2002 C CA  . ILE A 1 261 ? 102.335 102.865 110.716 1 62.184  ? 699 ILE A CA  1 
ATOM   2003 C C   . ILE A 1 261 ? 102.776 102.707 112.168 1 57.614  ? 699 ILE A C   1 
ATOM   2004 O O   . ILE A 1 261 ? 102.552 103.586 112.976 1 64.897  ? 699 ILE A O   1 
ATOM   2005 C CB  . ILE A 1 261 ? 101.056 102.054 110.404 1 74.115  ? 699 ILE A CB  1 
ATOM   2006 C CG1 . ILE A 1 261 ? 100.378 102.58  109.135 1 69.851  ? 699 ILE A CG1 1 
ATOM   2007 C CG2 . ILE A 1 261 ? 100.079 102.05  111.578 1 73.479  ? 699 ILE A CG2 1 
ATOM   2008 C CD1 . ILE A 1 261 ? 99.611  101.52  108.395 1 70.581  ? 699 ILE A CD1 1 
ATOM   2009 N N   . GLU A 1 262 ? 103.416 101.595 112.501 1 59.744  ? 700 GLU A N   1 
ATOM   2010 C CA  . GLU A 1 262 ? 103.841 101.366 113.873 1 65.914  ? 700 GLU A CA  1 
ATOM   2011 C C   . GLU A 1 262 ? 105.278 101.793 114.179 1 61.203  ? 700 GLU A C   1 
ATOM   2012 O O   . GLU A 1 262 ? 105.606 101.92  115.34  1 74.196  ? 700 GLU A O   1 
ATOM   2013 C CB  . GLU A 1 262 ? 103.775 99.897  114.229 1 58.374  ? 700 GLU A CB  1 
ATOM   2014 C CG  . GLU A 1 262 ? 102.461 99.233  113.88  1 76.554  ? 700 GLU A CG  1 
ATOM   2015 C CD  . GLU A 1 262 ? 101.358 99.408  114.892 1 97.414  ? 700 GLU A CD  1 
ATOM   2016 O OE1 . GLU A 1 262 ? 101.356 100.365 115.709 1 101.691 ? 700 GLU A OE1 1 
ATOM   2017 O OE2 . GLU A 1 262 ? 100.488 98.519  114.832 1 102.997 ? 700 GLU A OE2 1 
ATOM   2018 N N   . GLY A 1 263 ? 106.112 102.024 113.16  1 68.782  ? 701 GLY A N   1 
ATOM   2019 C CA  . GLY A 1 263 ? 107.527 102.3   113.363 1 61.08   ? 701 GLY A CA  1 
ATOM   2020 C C   . GLY A 1 263 ? 108.351 101.02  113.501 1 54.806  ? 701 GLY A C   1 
ATOM   2021 O O   . GLY A 1 263 ? 107.846 99.944  113.822 1 64.855  ? 701 GLY A O   1 
ATOM   2022 N N   . ARG A 1 264 ? 109.643 101.149 113.261 1 57.706  ? 702 ARG A N   1 
ATOM   2023 C CA  . ARG A 1 264 ? 110.593 100.058 113.428 1 60.088  ? 702 ARG A CA  1 
ATOM   2024 C C   . ARG A 1 264 ? 111.961 100.711 113.616 1 62.227  ? 702 ARG A C   1 
ATOM   2025 O O   . ARG A 1 264 ? 112.33  101.604 112.855 1 66.961  ? 702 ARG A O   1 
ATOM   2026 C CB  . ARG A 1 264 ? 110.601 99.12   112.221 1 61.124  ? 702 ARG A CB  1 
ATOM   2027 C CG  . ARG A 1 264 ? 111.461 97.876  112.363 1 60.614  ? 702 ARG A CG  1 
ATOM   2028 C CD  . ARG A 1 264 ? 111.024 96.785  111.445 1 63.349  ? 702 ARG A CD  1 
ATOM   2029 N NE  . ARG A 1 264 ? 111.635 95.513  111.835 1 72.631  ? 702 ARG A NE  1 
ATOM   2030 C CZ  . ARG A 1 264 ? 112.799 95.042  111.382 1 68.831  ? 702 ARG A CZ  1 
ATOM   2031 N NH1 . ARG A 1 264 ? 113.479 95.679  110.464 1 68.046  ? 702 ARG A NH1 1 
ATOM   2032 N NH2 . ARG A 1 264 ? 113.263 93.908  111.829 1 58.864  ? 702 ARG A NH2 1 
ATOM   2033 N N   . GLY A 1 265 ? 112.718 100.279 114.626 1 60.729  ? 703 GLY A N   1 
ATOM   2034 C CA  . GLY A 1 265 ? 113.965 100.935 114.95  1 58.805  ? 703 GLY A CA  1 
ATOM   2035 C C   . GLY A 1 265 ? 113.663 102.301 115.531 1 58.906  ? 703 GLY A C   1 
ATOM   2036 O O   . GLY A 1 265 ? 112.882 102.398 116.455 1 71.809  ? 703 GLY A O   1 
ATOM   2037 N N   . LYS A 1 266 ? 114.194 103.361 114.932 1 57.095  ? 704 LYS A N   1 
ATOM   2038 C CA  . LYS A 1 266 ? 113.988 104.699 115.455 1 61.965  ? 704 LYS A CA  1 
ATOM   2039 C C   . LYS A 1 266 ? 113.084 105.507 114.528 1 62.08   ? 704 LYS A C   1 
ATOM   2040 O O   . LYS A 1 266 ? 113.211 105.45  113.315 1 65.454  ? 704 LYS A O   1 
ATOM   2041 C CB  . LYS A 1 266 ? 115.346 105.398 115.607 1 64.276  ? 704 LYS A CB  1 
ATOM   2042 C CG  . LYS A 1 266 ? 116.147 104.796 116.745 1 68.736  ? 704 LYS A CG  1 
ATOM   2043 C CD  . LYS A 1 266 ? 117.622 105.028 116.64  1 83.125  ? 704 LYS A CD  1 
ATOM   2044 C CE  . LYS A 1 266 ? 118.36  104.335 117.729 1 86.157  ? 704 LYS A CE  1 
ATOM   2045 N NZ  . LYS A 1 266 ? 118.108 102.908 117.703 1 67.491  ? 704 LYS A NZ  1 
ATOM   2046 N N   . SER A 1 267 ? 112.189 106.278 115.139 1 58.352  ? 705 SER A N   1 
ATOM   2047 C CA  . SER A 1 267 ? 111.312 107.189 114.45  1 59.531  ? 705 SER A CA  1 
ATOM   2048 C C   . SER A 1 267 ? 111.78  108.601 114.728 1 57.204  ? 705 SER A C   1 
ATOM   2049 O O   . SER A 1 267 ? 111.921 108.982 115.881 1 62.444  ? 705 SER A O   1 
ATOM   2050 C CB  . SER A 1 267 ? 109.887 107.025 114.891 1 60.786  ? 705 SER A CB  1 
ATOM   2051 O OG  . SER A 1 267 ? 109.451 105.69  114.695 1 64.746  ? 705 SER A OG  1 
ATOM   2052 N N   . VAL A 1 268 ? 112.02  109.365 113.67  1 57.487  ? 706 VAL A N   1 
ATOM   2053 C CA  . VAL A 1 268 ? 112.645 110.665 113.817 1 59.309  ? 706 VAL A CA  1 
ATOM   2054 C C   . VAL A 1 268 ? 111.846 111.683 113.021 1 56.92   ? 706 VAL A C   1 
ATOM   2055 O O   . VAL A 1 268 ? 111.227 111.37  112.015 1 60.04   ? 706 VAL A O   1 
ATOM   2056 C CB  . VAL A 1 268 ? 114.126 110.628 113.376 1 61.807  ? 706 VAL A CB  1 
ATOM   2057 C CG1 . VAL A 1 268 ? 114.848 111.922 113.649 1 66.322  ? 706 VAL A CG1 1 
ATOM   2058 C CG2 . VAL A 1 268 ? 114.888 109.537 114.095 1 66.408  ? 706 VAL A CG2 1 
ATOM   2059 N N   . VAL A 1 269 ? 111.888 112.919 113.496 1 60.659  ? 707 VAL A N   1 
ATOM   2060 C CA  . VAL A 1 269 ? 111.391 114.052 112.757 1 58.35   ? 707 VAL A CA  1 
ATOM   2061 C C   . VAL A 1 269 ? 112.451 115.149 112.809 1 61.941  ? 707 VAL A C   1 
ATOM   2062 O O   . VAL A 1 269 ? 112.992 115.433 113.864 1 61.997  ? 707 VAL A O   1 
ATOM   2063 C CB  . VAL A 1 269 ? 110.048 114.538 113.341 1 61.337  ? 707 VAL A CB  1 
ATOM   2064 C CG1 . VAL A 1 269 ? 110.172 114.977 114.797 1 59.39   ? 707 VAL A CG1 1 
ATOM   2065 C CG2 . VAL A 1 269 ? 109.46  115.669 112.507 1 58.81   ? 707 VAL A CG2 1 
ATOM   2066 N N   . CYS A 1 270 ? 112.664 115.821 111.691 1 59.663  ? 708 CYS A N   1 
ATOM   2067 C CA  . CYS A 1 270 ? 113.59  116.938 111.622 1 65.689  ? 708 CYS A CA  1 
ATOM   2068 C C   . CYS A 1 270 ? 112.882 118.08  110.903 1 61.013  ? 708 CYS A C   1 
ATOM   2069 O O   . CYS A 1 270 ? 112.036 117.853 110.047 1 72.157  ? 708 CYS A O   1 
ATOM   2070 C CB  . CYS A 1 270 ? 114.852 116.545 110.844 1 70.498  ? 708 CYS A CB  1 
ATOM   2071 S SG  . CYS A 1 270 ? 116.113 117.841 110.83  1 93.989  ? 708 CYS A SG  1 
ATOM   2072 N N   . GLU A 1 271 ? 113.258 119.301 111.228 1 61.982  ? 709 GLU A N   1 
ATOM   2073 C CA  . GLU A 1 271 ? 112.656 120.456 110.61  1 67.291  ? 709 GLU A CA  1 
ATOM   2074 C C   . GLU A 1 271 ? 113.676 121.583 110.513 1 64.895  ? 709 GLU A C   1 
ATOM   2075 O O   . GLU A 1 271 ? 114.663 121.601 111.227 1 68.353  ? 709 GLU A O   1 
ATOM   2076 C CB  . GLU A 1 271 ? 111.433 120.899 111.407 1 72.492  ? 709 GLU A CB  1 
ATOM   2077 C CG  . GLU A 1 271 ? 111.768 121.354 112.82  1 82.127  ? 709 GLU A CG  1 
ATOM   2078 C CD  . GLU A 1 271 ? 110.562 121.731 113.647 1 99.108  ? 709 GLU A CD  1 
ATOM   2079 O OE1 . GLU A 1 271 ? 109.598 122.296 113.066 1 102.25  ? 709 GLU A OE1 1 
ATOM   2080 O OE2 . GLU A 1 271 ? 110.612 121.481 114.881 1 93.255  ? 709 GLU A OE2 1 
ATOM   2081 N N   . ALA A 1 272 ? 113.393 122.527 109.625 1 61.898  ? 710 ALA A N   1 
ATOM   2082 C CA  . ALA A 1 272 ? 114.152 123.753 109.516 1 64.085  ? 710 ALA A CA  1 
ATOM   2083 C C   . ALA A 1 272 ? 113.266 124.825 108.883 1 66.436  ? 710 ALA A C   1 
ATOM   2084 O O   . ALA A 1 272 ? 112.231 124.52  108.283 1 75.667  ? 710 ALA A O   1 
ATOM   2085 C CB  . ALA A 1 272 ? 115.4   123.499 108.714 1 62.683  ? 710 ALA A CB  1 
ATOM   2086 N N   . VAL A 1 273 ? 113.685 126.069 109.036 1 61.786  ? 711 VAL A N   1 
ATOM   2087 C CA  . VAL A 1 273 ? 113.102 127.195 108.342 1 69.884  ? 711 VAL A CA  1 
ATOM   2088 C C   . VAL A 1 273 ? 114.188 127.903 107.533 1 68.559  ? 711 VAL A C   1 
ATOM   2089 O O   . VAL A 1 273 ? 115.181 128.333 108.093 1 73.901  ? 711 VAL A O   1 
ATOM   2090 C CB  . VAL A 1 273 ? 112.427 128.165 109.326 1 70.502  ? 711 VAL A CB  1 
ATOM   2091 C CG1 . VAL A 1 273 ? 111.85  129.363 108.605 1 73.255  ? 711 VAL A CG1 1 
ATOM   2092 C CG2 . VAL A 1 273 ? 111.311 127.501 110.102 1 76.255  ? 711 VAL A CG2 1 
ATOM   2093 N N   . ILE A 1 274 ? 113.971 128.026 106.225 1 68.044  ? 712 ILE A N   1 
ATOM   2094 C CA  . ILE A 1 274 ? 114.903 128.65  105.308 1 71.084  ? 712 ILE A CA  1 
ATOM   2095 C C   . ILE A 1 274 ? 114.385 130.043 104.983 1 72.609  ? 712 ILE A C   1 
ATOM   2096 O O   . ILE A 1 274 ? 113.293 130.179 104.447 1 75.088  ? 712 ILE A O   1 
ATOM   2097 C CB  . ILE A 1 274 ? 115.064 127.815 104.027 1 68.253  ? 712 ILE A CB  1 
ATOM   2098 C CG1 . ILE A 1 274 ? 115.151 126.327 104.32  1 71.216  ? 712 ILE A CG1 1 
ATOM   2099 C CG2 . ILE A 1 274 ? 116.248 128.297 103.194 1 68.932  ? 712 ILE A CG2 1 
ATOM   2100 C CD1 . ILE A 1 274 ? 116.275 125.947 105.258 1 76.585  ? 712 ILE A CD1 1 
ATOM   2101 N N   . PRO A 1 275 ? 115.116 131.126 105.315 1 75.513  ? 713 PRO A N   1 
ATOM   2102 C CA  . PRO A 1 275 ? 114.676 132.465 104.941 1 79.469  ? 713 PRO A CA  1 
ATOM   2103 C C   . PRO A 1 275 ? 114.47  132.6   103.439 1 72.964  ? 713 PRO A C   1 
ATOM   2104 O O   . PRO A 1 275 ? 115.137 131.929 102.658 1 74.921  ? 713 PRO A O   1 
ATOM   2105 C CB  . PRO A 1 275 ? 115.809 133.376 105.424 1 76.033  ? 713 PRO A CB  1 
ATOM   2106 C CG  . PRO A 1 275 ? 116.444 132.573 106.543 1 78.56   ? 713 PRO A CG  1 
ATOM   2107 C CD  . PRO A 1 275 ? 116.352 131.131 106.11  1 73.858  ? 713 PRO A CD  1 
ATOM   2108 N N   . ALA A 1 276 ? 113.554 133.487 103.047 1 70.204  ? 714 ALA A N   1 
ATOM   2109 C CA  . ALA A 1 276 ? 113.238 133.718 101.646 1 73.399  ? 714 ALA A CA  1 
ATOM   2110 C C   . ALA A 1 276 ? 114.481 134.087 100.842 1 79.897  ? 714 ALA A C   1 
ATOM   2111 O O   . ALA A 1 276 ? 114.686 133.581 99.738  1 86.583  ? 714 ALA A O   1 
ATOM   2112 C CB  . ALA A 1 276 ? 112.203 134.805 101.532 1 75.834  ? 714 ALA A CB  1 
ATOM   2113 N N   . LYS A 1 277 ? 115.313 134.957 101.411 1 79.663  ? 715 LYS A N   1 
ATOM   2114 C CA  . LYS A 1 277 ? 116.499 135.428 100.721 1 83.27   ? 715 LYS A CA  1 
ATOM   2115 C C   . LYS A 1 277 ? 117.443 134.261 100.456 1 84.084  ? 715 LYS A C   1 
ATOM   2116 O O   . LYS A 1 277 ? 118.03  134.154 99.389  1 77.558  ? 715 LYS A O   1 
ATOM   2117 C CB  . LYS A 1 277 ? 117.162 136.526 101.548 1 86.039  ? 715 LYS A CB  1 
ATOM   2118 C CG  . LYS A 1 277 ? 118.625 136.761 101.271 1 95.943  ? 715 LYS A CG  1 
ATOM   2119 C CD  . LYS A 1 277 ? 119.182 137.897 102.13  1 108.594 ? 715 LYS A CD  1 
ATOM   2120 C CE  . LYS A 1 277 ? 120.68  138.044 102.081 1 110.622 ? 715 LYS A CE  1 
ATOM   2121 N NZ  . LYS A 1 277 ? 121.146 138.393 100.735 1 106.755 ? 715 LYS A NZ  1 
ATOM   2122 N N   . VAL A 1 278 ? 117.58  133.377 101.436 1 79.173  ? 716 VAL A N   1 
ATOM   2123 C CA  . VAL A 1 278 ? 118.445 132.225 101.276 1 76.228  ? 716 VAL A CA  1 
ATOM   2124 C C   . VAL A 1 278 ? 117.866 131.281 100.231 1 79.408  ? 716 VAL A C   1 
ATOM   2125 O O   . VAL A 1 278 ? 118.6   130.68  99.459  1 78.351  ? 716 VAL A O   1 
ATOM   2126 C CB  . VAL A 1 278 ? 118.638 131.527 102.627 1 78.551  ? 716 VAL A CB  1 
ATOM   2127 C CG1 . VAL A 1 278 ? 119.41  130.233 102.491 1 74.896  ? 716 VAL A CG1 1 
ATOM   2128 C CG2 . VAL A 1 278 ? 119.322 132.472 103.607 1 71.501  ? 716 VAL A CG2 1 
ATOM   2129 N N   . VAL A 1 279 ? 116.546 131.126 100.203 1 83.232  ? 717 VAL A N   1 
ATOM   2130 C CA  . VAL A 1 279 ? 115.935 130.295 99.184  1 83.799  ? 717 VAL A CA  1 
ATOM   2131 C C   . VAL A 1 279 ? 116.222 130.892 97.806  1 71.1    ? 717 VAL A C   1 
ATOM   2132 O O   . VAL A 1 279 ? 116.432 130.161 96.851  1 81.02   ? 717 VAL A O   1 
ATOM   2133 C CB  . VAL A 1 279 ? 114.426 130.119 99.438  1 83.732  ? 717 VAL A CB  1 
ATOM   2134 C CG1 . VAL A 1 279 ? 113.748 129.445 98.272  1 74.933  ? 717 VAL A CG1 1 
ATOM   2135 C CG2 . VAL A 1 279 ? 114.144 129.326 100.702 1 81.922  ? 717 VAL A CG2 1 
ATOM   2136 N N   . ARG A 1 280 ? 116.22  132.207 97.686  1 72.469  ? 718 ARG A N   1 
ATOM   2137 C CA  . ARG A 1 280 ? 116.515 132.846 96.405  1 77.102  ? 718 ARG A CA  1 
ATOM   2138 C C   . ARG A 1 280 ? 117.98  132.661 95.991  1 79.119  ? 718 ARG A C   1 
ATOM   2139 O O   . ARG A 1 280 ? 118.26  132.279 94.863  1 86.248  ? 718 ARG A O   1 
ATOM   2140 C CB  . ARG A 1 280 ? 116.198 134.342 96.457  1 83.161  ? 718 ARG A CB  1 
ATOM   2141 C CG  . ARG A 1 280 ? 114.777 134.655 96.028  1 98.699  ? 718 ARG A CG  1 
ATOM   2142 C CD  . ARG A 1 280 ? 114.534 136.149 95.948  1 104.072 ? 718 ARG A CD  1 
ATOM   2143 N NE  . ARG A 1 280 ? 114.226 136.706 97.269  1 103.628 ? 718 ARG A NE  1 
ATOM   2144 C CZ  . ARG A 1 280 ? 114.993 137.545 97.952  1 104.858 ? 718 ARG A CZ  1 
ATOM   2145 N NH1 . ARG A 1 280 ? 116.175 137.925 97.48   1 115.783 ? 718 ARG A NH1 1 
ATOM   2146 N NH2 . ARG A 1 280 ? 114.569 138.007 99.117  1 101.52  ? 718 ARG A NH2 1 
ATOM   2147 N N   . GLU A 1 281 ? 118.922 132.913 96.899  1 80.214  ? 719 GLU A N   1 
ATOM   2148 C CA  . GLU A 1 281 ? 120.325 133.045 96.532  1 83.695  ? 719 GLU A CA  1 
ATOM   2149 C C   . GLU A 1 281 ? 121.072 131.716 96.516  1 90.446  ? 719 GLU A C   1 
ATOM   2150 O O   . GLU A 1 281 ? 121.932 131.512 95.665  1 99.058  ? 719 GLU A O   1 
ATOM   2151 C CB  . GLU A 1 281 ? 121.032 133.992 97.488  1 78.886  ? 719 GLU A CB  1 
ATOM   2152 C CG  . GLU A 1 281 ? 120.974 135.426 96.985  1 97.816  ? 719 GLU A CG  1 
ATOM   2153 C CD  . GLU A 1 281 ? 120.933 136.414 98.12   1 106.99  ? 719 GLU A CD  1 
ATOM   2154 O OE1 . GLU A 1 281 ? 120.179 137.404 97.977  1 118.84  ? 719 GLU A OE1 1 
ATOM   2155 O OE2 . GLU A 1 281 ? 121.632 136.179 99.137  1 108.061 ? 719 GLU A OE2 1 
ATOM   2156 N N   . VAL A 1 282 ? 120.774 130.829 97.462  1 75.733  ? 720 VAL A N   1 
ATOM   2157 C CA  . VAL A 1 282 ? 121.464 129.56  97.525  1 76.757  ? 720 VAL A CA  1 
ATOM   2158 C C   . VAL A 1 282 ? 120.732 128.507 96.697  1 76.206  ? 720 VAL A C   1 
ATOM   2159 O O   . VAL A 1 282 ? 121.365 127.735 95.99   1 85.236  ? 720 VAL A O   1 
ATOM   2160 C CB  . VAL A 1 282 ? 121.599 129.129 98.991  1 78.783  ? 720 VAL A CB  1 
ATOM   2161 C CG1 . VAL A 1 282 ? 122.19  127.739 99.108  1 75.594  ? 720 VAL A CG1 1 
ATOM   2162 C CG2 . VAL A 1 282 ? 122.405 130.147 99.782  1 77.3    ? 720 VAL A CG2 1 
ATOM   2163 N N   . LEU A 1 283 ? 119.403 128.45  96.811  1 74.875  ? 721 LEU A N   1 
ATOM   2164 C CA  . LEU A 1 283 ? 118.627 127.416 96.152  1 79.319  ? 721 LEU A CA  1 
ATOM   2165 C C   . LEU A 1 283 ? 118.15  127.855 94.776  1 73.122  ? 721 LEU A C   1 
ATOM   2166 O O   . LEU A 1 283 ? 117.672 127.022 94.017  1 72.134  ? 721 LEU A O   1 
ATOM   2167 C CB  . LEU A 1 283 ? 117.468 127.012 97.054  1 73.309  ? 721 LEU A CB  1 
ATOM   2168 C CG  . LEU A 1 283 ? 117.892 126.508 98.433  1 75.402  ? 721 LEU A CG  1 
ATOM   2169 C CD1 . LEU A 1 283 ? 116.714 126.13  99.308  1 72.293  ? 721 LEU A CD1 1 
ATOM   2170 C CD2 . LEU A 1 283 ? 118.827 125.338 98.282  1 71.836  ? 721 LEU A CD2 1 
ATOM   2171 N N   . LYS A 1 284 ? 118.267 129.146 94.452  1 75.971  ? 722 LYS A N   1 
ATOM   2172 C CA  . LYS A 1 284 ? 117.981 129.641 93.105  1 75.977  ? 722 LYS A CA  1 
ATOM   2173 C C   . LYS A 1 284 ? 116.523 129.386 92.729  1 74.518  ? 722 LYS A C   1 
ATOM   2174 O O   . LYS A 1 284 ? 116.229 129.03  91.592  1 91.046  ? 722 LYS A O   1 
ATOM   2175 C CB  . LYS A 1 284 ? 118.89  128.99  92.052  1 78.219  ? 722 LYS A CB  1 
ATOM   2176 C CG  . LYS A 1 284 ? 120.383 129.144 92.29   1 79.583  ? 722 LYS A CG  1 
ATOM   2177 C CD  . LYS A 1 284 ? 120.823 130.59  92.306  1 91.065  ? 722 LYS A CD  1 
ATOM   2178 C CE  . LYS A 1 284 ? 122.311 130.745 92.312  1 99.884  ? 722 LYS A CE  1 
ATOM   2179 N NZ  . LYS A 1 284 ? 122.902 130.241 93.545  1 95.745  ? 722 LYS A NZ  1 
ATOM   2180 N N   . THR A 1 285 ? 115.609 129.571 93.685  1 77.199  ? 723 THR A N   1 
ATOM   2181 C CA  . THR A 1 285 ? 114.189 129.404 93.422  1 76.785  ? 723 THR A CA  1 
ATOM   2182 C C   . THR A 1 285 ? 113.405 130.322 94.358  1 75.379  ? 723 THR A C   1 
ATOM   2183 O O   . THR A 1 285 ? 113.968 131.266 94.906  1 89.583  ? 723 THR A O   1 
ATOM   2184 C CB  . THR A 1 285 ? 113.827 127.918 93.565  1 81.655  ? 723 THR A CB  1 
ATOM   2185 O OG1 . THR A 1 285 ? 112.462 127.72  93.226  1 80.222  ? 723 THR A OG1 1 
ATOM   2186 C CG2 . THR A 1 285 ? 114.015 127.398 94.972  1 80.227  ? 723 THR A CG2 1 
ATOM   2187 N N   . THR A 1 286 ? 112.113 130.033 94.546  1 70.598  ? 724 THR A N   1 
ATOM   2188 C CA  . THR A 1 286 ? 111.28  130.764 95.491  1 72.526  ? 724 THR A CA  1 
ATOM   2189 C C   . THR A 1 286 ? 110.525 129.769 96.36   1 73.609  ? 724 THR A C   1 
ATOM   2190 O O   . THR A 1 286 ? 110.397 128.588 96.018  1 77.277  ? 724 THR A O   1 
ATOM   2191 C CB  . THR A 1 286 ? 110.302 131.713 94.793  1 81.982  ? 724 THR A CB  1 
ATOM   2192 O OG1 . THR A 1 286 ? 109.256 130.95  94.203  1 81.932  ? 724 THR A OG1 1 
ATOM   2193 C CG2 . THR A 1 286 ? 110.96  132.539 93.703  1 83.914  ? 724 THR A CG2 1 
ATOM   2194 N N   . THR A 1 287 ? 110.002 130.263 97.485  1 68.726  ? 725 THR A N   1 
ATOM   2195 C CA  . THR A 1 287 ? 109.279 129.426 98.429  1 73.333  ? 725 THR A CA  1 
ATOM   2196 C C   . THR A 1 287 ? 108.02  128.849 97.775  1 80.038  ? 725 THR A C   1 
ATOM   2197 O O   . THR A 1 287 ? 107.698 127.673 98.002  1 63.661  ? 725 THR A O   1 
ATOM   2198 C CB  . THR A 1 287 ? 108.909 130.225 99.679  1 75.407  ? 725 THR A CB  1 
ATOM   2199 O OG1 . THR A 1 287 ? 110.104 130.432 100.418 1 76.675  ? 725 THR A OG1 1 
ATOM   2200 C CG2 . THR A 1 287 ? 107.903 129.503 100.558 1 71.623  ? 725 THR A CG2 1 
ATOM   2201 N N   . GLU A 1 288 ? 107.32  129.685 96.992  1 70.229  ? 726 GLU A N   1 
ATOM   2202 C CA  . GLU A 1 288 ? 106.068 129.269 96.378  1 75.37   ? 726 GLU A CA  1 
ATOM   2203 C C   . GLU A 1 288 ? 106.301 128.098 95.42   1 69.98   ? 726 GLU A C   1 
ATOM   2204 O O   . GLU A 1 288 ? 105.559 127.113 95.44   1 76.335  ? 726 GLU A O   1 
ATOM   2205 C CB  . GLU A 1 288 ? 105.381 130.426 95.663  1 81.793  ? 726 GLU A CB  1 
ATOM   2206 C CG  . GLU A 1 288 ? 105.107 131.607 96.59   1 103.415 ? 726 GLU A CG  1 
ATOM   2207 C CD  . GLU A 1 288 ? 106.341 132.375 97.062  1 121.735 ? 726 GLU A CD  1 
ATOM   2208 O OE1 . GLU A 1 288 ? 107.364 132.391 96.341  1 111.407 ? 726 GLU A OE1 1 
ATOM   2209 O OE2 . GLU A 1 288 ? 106.288 132.931 98.181  1 120.874 ? 726 GLU A OE2 1 
ATOM   2210 N N   . ALA A 1 289 ? 107.337 128.199 94.587  1 67.109  ? 727 ALA A N   1 
ATOM   2211 C CA  . ALA A 1 289 ? 107.66  127.13  93.658  1 65.233  ? 727 ALA A CA  1 
ATOM   2212 C C   . ALA A 1 289 ? 108.025 125.849 94.398  1 69.346  ? 727 ALA A C   1 
ATOM   2213 O O   . ALA A 1 289 ? 107.63  124.758 93.972  1 70.085  ? 727 ALA A O   1 
ATOM   2214 C CB  . ALA A 1 289 ? 108.762 127.552 92.74   1 61.049  ? 727 ALA A CB  1 
ATOM   2215 N N   . MET A 1 290 ? 108.769 125.987 95.5    1 63.877  ? 728 MET A N   1 
ATOM   2216 C CA  . MET A 1 290 ? 109.178 124.83  96.27   1 65.912  ? 728 MET A CA  1 
ATOM   2217 C C   . MET A 1 290 ? 107.948 124.122 96.828  1 66.739  ? 728 MET A C   1 
ATOM   2218 O O   . MET A 1 290 ? 107.851 122.894 96.764  1 63.169  ? 728 MET A O   1 
ATOM   2219 C CB  . MET A 1 290 ? 110.144 125.21  97.397  1 70.546  ? 728 MET A CB  1 
ATOM   2220 C CG  . MET A 1 290 ? 111.569 125.491 96.897  1 72.037  ? 728 MET A CG  1 
ATOM   2221 S SD  . MET A 1 290 ? 112.42  123.962 96.49   1 81.425  ? 728 MET A SD  1 
ATOM   2222 C CE  . MET A 1 290 ? 113.02  123.523 98.126  1 79.113  ? 728 MET A CE  1 
ATOM   2223 N N   . ILE A 1 291 ? 106.999 124.885 97.368  1 65.662  ? 729 ILE A N   1 
ATOM   2224 C CA  . ILE A 1 291 ? 105.809 124.281 97.934  1 69.687  ? 729 ILE A CA  1 
ATOM   2225 C C   . ILE A 1 291 ? 104.983 123.601 96.838  1 70.568  ? 729 ILE A C   1 
ATOM   2226 O O   . ILE A 1 291 ? 104.448 122.506 97.036  1 64.395  ? 729 ILE A O   1 
ATOM   2227 C CB  . ILE A 1 291 ? 104.983 125.31  98.718  1 74.579  ? 729 ILE A CB  1 
ATOM   2228 C CG1 . ILE A 1 291 ? 105.731 125.762 99.975  1 73.196  ? 729 ILE A CG1 1 
ATOM   2229 C CG2 . ILE A 1 291 ? 103.617 124.699 99.061  1 66.779  ? 729 ILE A CG2 1 
ATOM   2230 C CD1 . ILE A 1 291 ? 105.372 127.154 100.417 1 69.083  ? 729 ILE A CD1 1 
ATOM   2231 N N   . GLU A 1 292 ? 104.845 124.264 95.69   1 63.906  ? 730 GLU A N   1 
ATOM   2232 C CA  . GLU A 1 292 ? 104.093 123.696 94.586  1 67.854  ? 730 GLU A CA  1 
ATOM   2233 C C   . GLU A 1 292 ? 104.689 122.345 94.178  1 66.181  ? 730 GLU A C   1 
ATOM   2234 O O   . GLU A 1 292 ? 103.976 121.343 94.051  1 69.742  ? 730 GLU A O   1 
ATOM   2235 C CB  . GLU A 1 292 ? 104.07  124.673 93.416  1 71.098  ? 730 GLU A CB  1 
ATOM   2236 C CG  . GLU A 1 292 ? 103.044 124.309 92.346  1 89.068  ? 730 GLU A CG  1 
ATOM   2237 C CD  . GLU A 1 292 ? 103.062 125.206 91.114  1 107.453 ? 730 GLU A CD  1 
ATOM   2238 O OE1 . GLU A 1 292 ? 102.078 125.147 90.334  1 116.778 ? 730 GLU A OE1 1 
ATOM   2239 O OE2 . GLU A 1 292 ? 104.051 125.951 90.916  1 115.065 ? 730 GLU A OE2 1 
ATOM   2240 N N   . VAL A 1 293 ? 106.007 122.303 94.026  1 63.94   ? 731 VAL A N   1 
ATOM   2241 C CA  . VAL A 1 293 ? 106.654 121.079 93.606  1 64.894  ? 731 VAL A CA  1 
ATOM   2242 C C   . VAL A 1 293 ? 106.501 120.006 94.685  1 64.388  ? 731 VAL A C   1 
ATOM   2243 O O   . VAL A 1 293 ? 106.238 118.852 94.391  1 63.035  ? 731 VAL A O   1 
ATOM   2244 C CB  . VAL A 1 293 ? 108.125 121.329 93.239  1 67.541  ? 731 VAL A CB  1 
ATOM   2245 C CG1 . VAL A 1 293 ? 108.848 120.033 92.921  1 80.881  ? 731 VAL A CG1 1 
ATOM   2246 C CG2 . VAL A 1 293 ? 108.245 122.254 92.052  1 74.434  ? 731 VAL A CG2 1 
ATOM   2247 N N   . ASN A 1 294 ? 106.686 120.376 95.937  1 55.447  ? 732 ASN A N   1 
ATOM   2248 C CA  . ASN A 1 294 ? 106.552 119.43  97.023  1 60.425  ? 732 ASN A CA  1 
ATOM   2249 C C   . ASN A 1 294 ? 105.158 118.799 97.021  1 58.47   ? 732 ASN A C   1 
ATOM   2250 O O   . ASN A 1 294 ? 105.005 117.581 97.065  1 56.149  ? 732 ASN A O   1 
ATOM   2251 C CB  . ASN A 1 294 ? 106.881 120.088 98.363  1 64      ? 732 ASN A CB  1 
ATOM   2252 C CG  . ASN A 1 294 ? 106.856 119.086 99.488  1 70.083  ? 732 ASN A CG  1 
ATOM   2253 O OD1 . ASN A 1 294 ? 107.733 118.232 99.559  1 70.714  ? 732 ASN A OD1 1 
ATOM   2254 N ND2 . ASN A 1 294 ? 105.869 119.166 100.364 1 82.82   ? 732 ASN A ND2 1 
ATOM   2255 N N   . ILE A 1 295 ? 104.121 119.611 96.95   1 58.136  ? 733 ILE A N   1 
ATOM   2256 C CA  . ILE A 1 295 ? 102.777 119.067 96.947  1 62.804  ? 733 ILE A CA  1 
ATOM   2257 C C   . ILE A 1 295 ? 102.566 118.134 95.754  1 60.199  ? 733 ILE A C   1 
ATOM   2258 O O   . ILE A 1 295 ? 102.083 117.014 95.898  1 57.467  ? 733 ILE A O   1 
ATOM   2259 C CB  . ILE A 1 295 ? 101.717 120.178 96.977  1 71.092  ? 733 ILE A CB  1 
ATOM   2260 C CG1 . ILE A 1 295 ? 101.635 120.826 98.36   1 69.31   ? 733 ILE A CG1 1 
ATOM   2261 C CG2 . ILE A 1 295 ? 100.362 119.597 96.563  1 65.231  ? 733 ILE A CG2 1 
ATOM   2262 C CD1 . ILE A 1 295 ? 101.096 122.231 98.331  1 73.552  ? 733 ILE A CD1 1 
ATOM   2263 N N   . ASN A 1 296 ? 102.916 118.586 94.563  1 58.492  ? 734 ASN A N   1 
ATOM   2264 C CA  . ASN A 1 296 ? 102.508 117.897 93.35   1 62.615  ? 734 ASN A CA  1 
ATOM   2265 C C   . ASN A 1 296 ? 103.459 116.772 92.969  1 61.784  ? 734 ASN A C   1 
ATOM   2266 O O   . ASN A 1 296 ? 103.142 116.023 92.059  1 65.789  ? 734 ASN A O   1 
ATOM   2267 C CB  . ASN A 1 296 ? 102.331 118.905 92.215  1 65.054  ? 734 ASN A CB  1 
ATOM   2268 C CG  . ASN A 1 296 ? 101.181 119.842 92.523  1 62.067  ? 734 ASN A CG  1 
ATOM   2269 O OD1 . ASN A 1 296 ? 100.103 119.351 92.825  1 61.344  ? 734 ASN A OD1 1 
ATOM   2270 N ND2 . ASN A 1 296 ? 101.362 121.152 92.49   1 68.687  ? 734 ASN A ND2 1 
ATOM   2271 N N   . LYS A 1 297 ? 104.599 116.641 93.66   1 63.245  ? 735 LYS A N   1 
ATOM   2272 C CA  . LYS A 1 297 ? 105.508 115.534 93.43   1 57.08   ? 735 LYS A CA  1 
ATOM   2273 C C   . LYS A 1 297 ? 105.503 114.57  94.617  1 58.434  ? 735 LYS A C   1 
ATOM   2274 O O   . LYS A 1 297 ? 105.289 113.378 94.426  1 58.488  ? 735 LYS A O   1 
ATOM   2275 C CB  . LYS A 1 297 ? 106.907 116.069 93.1    1 58.263  ? 735 LYS A CB  1 
ATOM   2276 C CG  . LYS A 1 297 ? 108.006 115.015 93.054  1 61.738  ? 735 LYS A CG  1 
ATOM   2277 C CD  . LYS A 1 297 ? 109.409 115.594 93.079  1 61.894  ? 735 LYS A CD  1 
ATOM   2278 C CE  . LYS A 1 297 ? 110.535 114.607 93.176  1 60.456  ? 735 LYS A CE  1 
ATOM   2279 N NZ  . LYS A 1 297 ? 110.537 113.603 92.107  1 61.799  ? 735 LYS A NZ  1 
ATOM   2280 N N   . ASN A 1 298 ? 105.792 115.055 95.823  1 58.305  ? 736 ASN A N   1 
ATOM   2281 C CA  . ASN A 1 298 ? 106.039 114.162 96.945  1 63.147  ? 736 ASN A CA  1 
ATOM   2282 C C   . ASN A 1 298 ? 104.732 113.637 97.534  1 61.875  ? 736 ASN A C   1 
ATOM   2283 O O   . ASN A 1 298 ? 104.726 112.545 98.109  1 62.073  ? 736 ASN A O   1 
ATOM   2284 C CB  . ASN A 1 298 ? 106.902 114.833 98.01   1 61.139  ? 736 ASN A CB  1 
ATOM   2285 C CG  . ASN A 1 298 ? 108.347 114.924 97.563  1 74.871  ? 736 ASN A CG  1 
ATOM   2286 O OD1 . ASN A 1 298 ? 108.813 114.102 96.759  1 67.903  ? 736 ASN A OD1 1 
ATOM   2287 N ND2 . ASN A 1 298 ? 109.079 115.891 98.092  1 65.767  ? 736 ASN A ND2 1 
ATOM   2288 N N   . LEU A 1 299 ? 103.647 114.418 97.427  1 58.52   ? 737 LEU A N   1 
ATOM   2289 C CA  . LEU A 1 299 ? 102.351 113.991 97.921  1 58.597  ? 737 LEU A CA  1 
ATOM   2290 C C   . LEU A 1 299 ? 101.522 113.402 96.793  1 61.133  ? 737 LEU A C   1 
ATOM   2291 O O   . LEU A 1 299 ? 101.157 112.245 96.865  1 57.822  ? 737 LEU A O   1 
ATOM   2292 C CB  . LEU A 1 299 ? 101.639 115.163 98.595  1 59.952  ? 737 LEU A CB  1 
ATOM   2293 C CG  . LEU A 1 299 ? 102.396 115.805 99.759  1 63.3    ? 737 LEU A CG  1 
ATOM   2294 C CD1 . LEU A 1 299 ? 101.516 116.803 100.48  1 63.708  ? 737 LEU A CD1 1 
ATOM   2295 C CD2 . LEU A 1 299 ? 102.897 114.765 100.743 1 70.173  ? 737 LEU A CD2 1 
ATOM   2296 N N   . VAL A 1 300 ? 101.174 114.203 95.78   1 56.617  ? 738 VAL A N   1 
ATOM   2297 C CA  . VAL A 1 300 ? 100.215 113.763 94.781  1 54.394  ? 738 VAL A CA  1 
ATOM   2298 C C   . VAL A 1 300 ? 100.859 112.748 93.849  1 55.989  ? 738 VAL A C   1 
ATOM   2299 O O   . VAL A 1 300 ? 100.292 111.693 93.608  1 60.304  ? 738 VAL A O   1 
ATOM   2300 C CB  . VAL A 1 300 ? 99.639  114.954 94      1 57.584  ? 738 VAL A CB  1 
ATOM   2301 C CG1 . VAL A 1 300 ? 98.618  114.494 92.985  1 57.706  ? 738 VAL A CG1 1 
ATOM   2302 C CG2 . VAL A 1 300 ? 99.026  115.979 94.932  1 55.763  ? 738 VAL A CG2 1 
ATOM   2303 N N   . GLY A 1 301 ? 102.059 113.012 93.358  1 53.934  ? 739 GLY A N   1 
ATOM   2304 C CA  . GLY A 1 301 ? 102.724 112.035 92.504  1 52.844  ? 739 GLY A CA  1 
ATOM   2305 C C   . GLY A 1 301 ? 102.945 110.698 93.183  1 51.197  ? 739 GLY A C   1 
ATOM   2306 O O   . GLY A 1 301 ? 102.747 109.66  92.583  1 58.389  ? 739 GLY A O   1 
ATOM   2307 N N   . SER A 1 302 ? 103.363 110.699 94.444  1 60.818  ? 740 SER A N   1 
ATOM   2308 C CA  . SER A 1 302 ? 103.536 109.452 95.173  1 55.415  ? 740 SER A CA  1 
ATOM   2309 C C   . SER A 1 302 ? 102.197 108.744 95.347  1 52.177  ? 740 SER A C   1 
ATOM   2310 O O   . SER A 1 302 ? 102.132 107.515 95.259  1 54.073  ? 740 SER A O   1 
ATOM   2311 C CB  . SER A 1 302 ? 104.204 109.705 96.512  1 57.727  ? 740 SER A CB  1 
ATOM   2312 O OG  . SER A 1 302 ? 105.518 110.196 96.335  1 64.254  ? 740 SER A OG  1 
ATOM   2313 N N   . ALA A 1 303 ? 101.134 109.5   95.641  1 51.27   ? 741 ALA A N   1 
ATOM   2314 C CA  . ALA A 1 303 ? 99.781  108.943 95.759  1 55.445  ? 741 ALA A CA  1 
ATOM   2315 C C   . ALA A 1 303 ? 99.321  108.286 94.456  1 54.067  ? 741 ALA A C   1 
ATOM   2316 O O   . ALA A 1 303 ? 98.839  107.166 94.471  1 51.793  ? 741 ALA A O   1 
ATOM   2317 C CB  . ALA A 1 303 ? 98.805  110.032 96.19   1 54.069  ? 741 ALA A CB  1 
ATOM   2318 N N   . MET A 1 304 ? 99.558  108.94  93.311  1 56.386  ? 742 MET A N   1 
ATOM   2319 C CA  . MET A 1 304 ? 99.158  108.375 92.025  1 53.804  ? 742 MET A CA  1 
ATOM   2320 C C   . MET A 1 304 ? 99.984  107.132 91.695  1 55.299  ? 742 MET A C   1 
ATOM   2321 O O   . MET A 1 304 ? 99.514  106.255 91.004  1 65.004  ? 742 MET A O   1 
ATOM   2322 C CB  . MET A 1 304 ? 99.314  109.39  90.898  1 58.319  ? 742 MET A CB  1 
ATOM   2323 C CG  . MET A 1 304 ? 98.561  110.686 91.104  1 60.074  ? 742 MET A CG  1 
ATOM   2324 S SD  . MET A 1 304 ? 96.83   110.543 91.61   1 68.578  ? 742 MET A SD  1 
ATOM   2325 C CE  . MET A 1 304 ? 96.175  109.402 90.399  1 67.573  ? 742 MET A CE  1 
ATOM   2326 N N   . ALA A 1 305 ? 101.223 107.044 92.173  1 58.871  ? 743 ALA A N   1 
ATOM   2327 C CA  . ALA A 1 305 ? 102.049 105.862 91.961  1 54.922  ? 743 ALA A CA  1 
ATOM   2328 C C   . ALA A 1 305 ? 101.679 104.743 92.921  1 55.92   ? 743 ALA A C   1 
ATOM   2329 O O   . ALA A 1 305 ? 102.192 103.63  92.78   1 49.768  ? 743 ALA A O   1 
ATOM   2330 C CB  . ALA A 1 305 ? 103.517 106.22  92.148  1 57.485  ? 743 ALA A CB  1 
ATOM   2331 N N   . GLY A 1 306 ? 100.814 105.019 93.902  1 55.511  ? 744 GLY A N   1 
ATOM   2332 C CA  . GLY A 1 306 ? 100.46  103.968 94.844  1 57.693  ? 744 GLY A CA  1 
ATOM   2333 C C   . GLY A 1 306 ? 101.603 103.655 95.809  1 58.179  ? 744 GLY A C   1 
ATOM   2334 O O   . GLY A 1 306 ? 101.942 102.498 96.04   1 65.195  ? 744 GLY A O   1 
ATOM   2335 N N   . SER A 1 307 ? 102.235 104.698 96.325  1 65.265  ? 745 SER A N   1 
ATOM   2336 C CA  . SER A 1 307 ? 103.315 104.549 97.29   1 69.313  ? 745 SER A CA  1 
ATOM   2337 C C   . SER A 1 307 ? 102.801 104.432 98.725  1 68.831  ? 745 SER A C   1 
ATOM   2338 O O   . SER A 1 307 ? 101.928 105.182 99.14   1 76.576  ? 745 SER A O   1 
ATOM   2339 C CB  . SER A 1 307 ? 104.257 105.683 97.195  1 65.455  ? 745 SER A CB  1 
ATOM   2340 O OG  . SER A 1 307 ? 105.433 105.386 97.92   1 70.016  ? 745 SER A OG  1 
ATOM   2341 N N   . ILE A 1 308 ? 103.366 103.49  99.482  1 70.996  ? 746 ILE A N   1 
ATOM   2342 C CA  . ILE A 1 308 ? 103.246 103.464 100.928 1 64.714  ? 746 ILE A CA  1 
ATOM   2343 C C   . ILE A 1 308 ? 104.585 103.88  101.525 1 63.068  ? 746 ILE A C   1 
ATOM   2344 O O   . ILE A 1 308 ? 105.559 103.149 101.421 1 71.956  ? 746 ILE A O   1 
ATOM   2345 C CB  . ILE A 1 308 ? 102.876 102.066 101.434 1 75.282  ? 746 ILE A CB  1 
ATOM   2346 C CG1 . ILE A 1 308 ? 101.581 101.552 100.815 1 85.714  ? 746 ILE A CG1 1 
ATOM   2347 C CG2 . ILE A 1 308 ? 102.844 102.066 102.964 1 70.114  ? 746 ILE A CG2 1 
ATOM   2348 C CD1 . ILE A 1 308 ? 100.335 102.223 101.342 1 82.352  ? 746 ILE A CD1 1 
ATOM   2349 N N   . GLY A 1 309 ? 104.645 105.055 102.126 1 66.912  ? 747 GLY A N   1 
ATOM   2350 C CA  . GLY A 1 309 ? 105.848 105.488 102.812 1 68.136  ? 747 GLY A CA  1 
ATOM   2351 C C   . GLY A 1 309 ? 106.883 106.14  101.892 1 62.848  ? 747 GLY A C   1 
ATOM   2352 O O   . GLY A 1 309 ? 107.92  106.577 102.354 1 67.136  ? 747 GLY A O   1 
ATOM   2353 N N   . GLY A 1 310 ? 106.58  106.302 100.61  1 66.402  ? 748 GLY A N   1 
ATOM   2354 C CA  . GLY A 1 310 ? 107.526 106.893 99.672  1 57.523  ? 748 GLY A CA  1 
ATOM   2355 C C   . GLY A 1 310 ? 107.157 108.319 99.281  1 55.299  ? 748 GLY A C   1 
ATOM   2356 O O   . GLY A 1 310 ? 107.288 108.695 98.133  1 66.11   ? 748 GLY A O   1 
ATOM   2357 N N   . TYR A 1 311 ? 106.806 109.147 100.255 1 57.422  ? 749 TYR A N   1 
ATOM   2358 C CA  . TYR A 1 311 ? 106.371 110.505 99.996  1 53.982  ? 749 TYR A CA  1 
ATOM   2359 C C   . TYR A 1 311 ? 107.516 111.499 100.126 1 58.208  ? 749 TYR A C   1 
ATOM   2360 O O   . TYR A 1 311 ? 107.438 112.459 100.906 1 54.592  ? 749 TYR A O   1 
ATOM   2361 C CB  . TYR A 1 311 ? 105.228 110.828 100.96  1 57.322  ? 749 TYR A CB  1 
ATOM   2362 C CG  . TYR A 1 311 ? 104.015 109.943 100.768 1 56.036  ? 749 TYR A CG  1 
ATOM   2363 C CD1 . TYR A 1 311 ? 103.893 108.749 101.456 1 63.146  ? 749 TYR A CD1 1 
ATOM   2364 C CD2 . TYR A 1 311 ? 103.038 110.29  99.841  1 60.519  ? 749 TYR A CD2 1 
ATOM   2365 C CE1 . TYR A 1 311 ? 102.809 107.914 101.236 1 67.395  ? 749 TYR A CE1 1 
ATOM   2366 C CE2 . TYR A 1 311 ? 101.95  109.47  99.626  1 70.076  ? 749 TYR A CE2 1 
ATOM   2367 C CZ  . TYR A 1 311 ? 101.841 108.281 100.317 1 64.836  ? 749 TYR A CZ  1 
ATOM   2368 O OH  . TYR A 1 311 ? 100.735 107.525 100.088 1 85.73   ? 749 TYR A OH  1 
ATOM   2369 N N   . ASN A 1 312 ? 108.567 111.258 99.34   1 56.483  ? 750 ASN A N   1 
ATOM   2370 C CA  . ASN A 1 312 ? 109.779 112.064 99.401  1 62.793  ? 750 ASN A CA  1 
ATOM   2371 C C   . ASN A 1 312 ? 110.473 112.024 98.043  1 59.411  ? 750 ASN A C   1 
ATOM   2372 O O   . ASN A 1 312 ? 110.109 111.241 97.16   1 56.527  ? 750 ASN A O   1 
ATOM   2373 C CB  . ASN A 1 312 ? 110.743 111.546 100.466 1 57.751  ? 750 ASN A CB  1 
ATOM   2374 C CG  . ASN A 1 312 ? 111.183 110.126 100.189 1 55.634  ? 750 ASN A CG  1 
ATOM   2375 O OD1 . ASN A 1 312 ? 112.195 109.882 99.529  1 53.018  ? 750 ASN A OD1 1 
ATOM   2376 N ND2 . ASN A 1 312 ? 110.425 109.142 100.651 1 56.207  ? 750 ASN A ND2 1 
ATOM   2377 N N   . ALA A 1 313 ? 111.482 112.867 97.879  1 60.351  ? 751 ALA A N   1 
ATOM   2378 C CA  . ALA A 1 313 ? 112.206 112.945 96.617  1 62.397  ? 751 ALA A CA  1 
ATOM   2379 C C   . ALA A 1 313 ? 113.228 111.81  96.49   1 66.954  ? 751 ALA A C   1 
ATOM   2380 O O   . ALA A 1 313 ? 113.077 110.967 95.603  1 71.04   ? 751 ALA A O   1 
ATOM   2381 C CB  . ALA A 1 313 ? 112.814 114.301 96.46   1 59.996  ? 751 ALA A CB  1 
ATOM   2382 N N   . HIS A 1 314 ? 114.27  111.757 97.341  1 60.859  ? 752 HIS A N   1 
ATOM   2383 C CA  . HIS A 1 314 ? 115.296 110.73  97.164  1 64.532  ? 752 HIS A CA  1 
ATOM   2384 C C   . HIS A 1 314 ? 115.959 110.363 98.488  1 61.46   ? 752 HIS A C   1 
ATOM   2385 O O   . HIS A 1 314 ? 117.164 110.194 98.554  1 63.933  ? 752 HIS A O   1 
ATOM   2386 C CB  . HIS A 1 314 ? 116.381 111.172 96.174  1 62.749  ? 752 HIS A CB  1 
ATOM   2387 C CG  . HIS A 1 314 ? 117.167 112.368 96.611  1 59.569  ? 752 HIS A CG  1 
ATOM   2388 N ND1 . HIS A 1 314 ? 118.502 112.491 96.302  1 62.498  ? 752 HIS A ND1 1 
ATOM   2389 C CD2 . HIS A 1 314 ? 116.856 113.454 97.28   1 62.621  ? 752 HIS A CD2 1 
ATOM   2390 C CE1 . HIS A 1 314 ? 118.961 113.644 96.756  1 55.599  ? 752 HIS A CE1 1 
ATOM   2391 N NE2 . HIS A 1 314 ? 117.981 114.256 97.363  1 61.593  ? 752 HIS A NE2 1 
ATOM   2392 N N   . ALA A 1 315 ? 115.179 110.202 99.546  1 57.767  ? 753 ALA A N   1 
ATOM   2393 C CA  . ALA A 1 315 ? 115.731 109.836 100.839 1 56.267  ? 753 ALA A CA  1 
ATOM   2394 C C   . ALA A 1 315 ? 116.62  108.584 100.768 1 56.539  ? 753 ALA A C   1 
ATOM   2395 O O   . ALA A 1 315 ? 117.602 108.484 101.469 1 59.092  ? 753 ALA A O   1 
ATOM   2396 C CB  . ALA A 1 315 ? 114.594 109.669 101.814 1 56.278  ? 753 ALA A CB  1 
ATOM   2397 N N   . ALA A 1 316 ? 116.312 107.638 99.893  1 57.7    ? 754 ALA A N   1 
ATOM   2398 C CA  . ALA A 1 316 ? 117.083 106.421 99.754  1 56.754  ? 754 ALA A CA  1 
ATOM   2399 C C   . ALA A 1 316 ? 118.532 106.693 99.345  1 60.176  ? 754 ALA A C   1 
ATOM   2400 O O   . ALA A 1 316 ? 119.422 105.989 99.802  1 63.414  ? 754 ALA A O   1 
ATOM   2401 C CB  . ALA A 1 316 ? 116.436 105.468 98.776  1 50.527  ? 754 ALA A CB  1 
ATOM   2402 N N   . ASN A 1 317 ? 118.773 107.721 98.53   1 59.16   ? 755 ASN A N   1 
ATOM   2403 C CA  . ASN A 1 317 ? 120.134 108.065 98.148  1 61.414  ? 755 ASN A CA  1 
ATOM   2404 C C   . ASN A 1 317 ? 120.994 108.38  99.371  1 57.281  ? 755 ASN A C   1 
ATOM   2405 O O   . ASN A 1 317 ? 122.039 107.772 99.581  1 64.327  ? 755 ASN A O   1 
ATOM   2406 C CB  . ASN A 1 317 ? 120.165 109.256 97.201  1 56.741  ? 755 ASN A CB  1 
ATOM   2407 C CG  . ASN A 1 317 ? 120.006 108.878 95.751  1 59.419  ? 755 ASN A CG  1 
ATOM   2408 O OD1 . ASN A 1 317 ? 120.263 107.736 95.359  1 67.49   ? 755 ASN A OD1 1 
ATOM   2409 N ND2 . ASN A 1 317 ? 119.607 109.845 94.943  1 63.168  ? 755 ASN A ND2 1 
ATOM   2410 N N   . ILE A 1 318 ? 120.507 109.302 100.207 1 62.817  ? 756 ILE A N   1 
ATOM   2411 C CA  . ILE A 1 318 ? 121.251 109.764 101.356 1 58.417  ? 756 ILE A CA  1 
ATOM   2412 C C   . ILE A 1 318 ? 121.404 108.618 102.342 1 61.949  ? 756 ILE A C   1 
ATOM   2413 O O   . ILE A 1 318 ? 122.488 108.381 102.884 1 65.709  ? 756 ILE A O   1 
ATOM   2414 C CB  . ILE A 1 318 ? 120.619 111.021 101.97  1 68.121  ? 756 ILE A CB  1 
ATOM   2415 C CG1 . ILE A 1 318 ? 120.947 112.272 101.164 1 69.517  ? 756 ILE A CG1 1 
ATOM   2416 C CG2 . ILE A 1 318 ? 121.078 111.197 103.425 1 62.373  ? 756 ILE A CG2 1 
ATOM   2417 C CD1 . ILE A 1 318 ? 120.307 112.357 99.801  1 78.933  ? 756 ILE A CD1 1 
ATOM   2418 N N   . VAL A 1 319 ? 120.303 107.9   102.569 1 59.786  ? 757 VAL A N   1 
ATOM   2419 C CA  . VAL A 1 319 ? 120.304 106.839 103.539 1 56.716  ? 757 VAL A CA  1 
ATOM   2420 C C   . VAL A 1 319 ? 121.336 105.791 103.138 1 64.528  ? 757 VAL A C   1 
ATOM   2421 O O   . VAL A 1 319 ? 122.1   105.314 103.976 1 58.116  ? 757 VAL A O   1 
ATOM   2422 C CB  . VAL A 1 319 ? 118.899 106.234 103.743 1 61.485  ? 757 VAL A CB  1 
ATOM   2423 C CG1 . VAL A 1 319 ? 118.966 104.943 104.53  1 56.506  ? 757 VAL A CG1 1 
ATOM   2424 C CG2 . VAL A 1 319 ? 117.955 107.207 104.455 1 62.888  ? 757 VAL A CG2 1 
ATOM   2425 N N   . THR A 1 320 ? 121.336 105.399 101.857 1 63.725  ? 758 THR A N   1 
ATOM   2426 C CA  . THR A 1 320 ? 122.218 104.338 101.398 1 63.481  ? 758 THR A CA  1 
ATOM   2427 C C   . THR A 1 320 ? 123.675 104.783 101.52  1 55.693  ? 758 THR A C   1 
ATOM   2428 O O   . THR A 1 320 ? 124.516 104.018 101.984 1 54.647  ? 758 THR A O   1 
ATOM   2429 C CB  . THR A 1 320 ? 121.913 103.949 99.954  1 65.119  ? 758 THR A CB  1 
ATOM   2430 O OG1 . THR A 1 320 ? 120.561 103.538 99.912  1 65.126  ? 758 THR A OG1 1 
ATOM   2431 C CG2 . THR A 1 320 ? 122.805 102.822 99.464  1 60.657  ? 758 THR A CG2 1 
ATOM   2432 N N   . ALA A 1 321 ? 123.955 106.016 101.112 1 51.324  ? 759 ALA A N   1 
ATOM   2433 C CA  . ALA A 1 321 ? 125.321 106.516 101.175 1 56.104  ? 759 ALA A CA  1 
ATOM   2434 C C   . ALA A 1 321 ? 125.845 106.512 102.613 1 64.713  ? 759 ALA A C   1 
ATOM   2435 O O   . ALA A 1 321 ? 126.921 105.975 102.878 1 61.968  ? 759 ALA A O   1 
ATOM   2436 C CB  . ALA A 1 321 ? 125.391 107.892 100.573 1 53.789  ? 759 ALA A CB  1 
ATOM   2437 N N   . ILE A 1 322 ? 125.068 107.063 103.557 1 66.855  ? 760 ILE A N   1 
ATOM   2438 C CA  . ILE A 1 322 ? 125.498 107.099 104.946 1 60.571  ? 760 ILE A CA  1 
ATOM   2439 C C   . ILE A 1 322 ? 125.643 105.675 105.482 1 60.982  ? 760 ILE A C   1 
ATOM   2440 O O   . ILE A 1 322 ? 126.593 105.388 106.205 1 56.685  ? 760 ILE A O   1 
ATOM   2441 C CB  . ILE A 1 322 ? 124.562 107.951 105.824 1 60.313  ? 760 ILE A CB  1 
ATOM   2442 C CG1 . ILE A 1 322 ? 124.531 109.381 105.372 1 61.269  ? 760 ILE A CG1 1 
ATOM   2443 C CG2 . ILE A 1 322 ? 124.949 107.851 107.298 1 65.755  ? 760 ILE A CG2 1 
ATOM   2444 C CD1 . ILE A 1 322 ? 123.547 110.265 106.121 1 61.124  ? 760 ILE A CD1 1 
ATOM   2445 N N   . TYR A 1 323 ? 124.678 104.801 105.166 1 59.455  ? 761 TYR A N   1 
ATOM   2446 C CA  . TYR A 1 323 ? 124.685 103.461 105.715 1 60.809  ? 761 TYR A CA  1 
ATOM   2447 C C   . TYR A 1 323 ? 125.957 102.741 105.285 1 64.21   ? 761 TYR A C   1 
ATOM   2448 O O   . TYR A 1 323 ? 126.558 102.023 106.08  1 70.32   ? 761 TYR A O   1 
ATOM   2449 C CB  . TYR A 1 323 ? 123.451 102.661 105.28  1 59.899  ? 761 TYR A CB  1 
ATOM   2450 C CG  . TYR A 1 323 ? 122.269 102.791 106.213 1 63.135  ? 761 TYR A CG  1 
ATOM   2451 C CD1 . TYR A 1 323 ? 122.026 103.958 106.931 1 65.29   ? 761 TYR A CD1 1 
ATOM   2452 C CD2 . TYR A 1 323 ? 121.382 101.741 106.353 1 66.187  ? 761 TYR A CD2 1 
ATOM   2453 C CE1 . TYR A 1 323 ? 120.935 104.06  107.781 1 68.128  ? 761 TYR A CE1 1 
ATOM   2454 C CE2 . TYR A 1 323 ? 120.294 101.823 107.205 1 67.13   ? 761 TYR A CE2 1 
ATOM   2455 C CZ  . TYR A 1 323 ? 120.073 102.984 107.921 1 65.694  ? 761 TYR A CZ  1 
ATOM   2456 O OH  . TYR A 1 323 ? 118.996 103.055 108.738 1 69.507  ? 761 TYR A OH  1 
ATOM   2457 N N   . ILE A 1 324 ? 126.319 102.858 104.005 1 65.944  ? 762 ILE A N   1 
ATOM   2458 C CA  . ILE A 1 324 ? 127.507 102.182 103.506 1 70.583  ? 762 ILE A CA  1 
ATOM   2459 C C   . ILE A 1 324 ? 128.75  102.8   104.143 1 62.271  ? 762 ILE A C   1 
ATOM   2460 O O   . ILE A 1 324 ? 129.676 102.089 104.492 1 64.536  ? 762 ILE A O   1 
ATOM   2461 C CB  . ILE A 1 324 ? 127.567 102.219 101.97  1 70.751  ? 762 ILE A CB  1 
ATOM   2462 C CG1 . ILE A 1 324 ? 126.515 101.289 101.383 1 72.215  ? 762 ILE A CG1 1 
ATOM   2463 C CG2 . ILE A 1 324 ? 128.974 101.854 101.486 1 69.053  ? 762 ILE A CG2 1 
ATOM   2464 C CD1 . ILE A 1 324 ? 126.269 101.474 99.898  1 67.856  ? 762 ILE A CD1 1 
ATOM   2465 N N   . ALA A 1 325 ? 128.78  104.128 104.289 1 64.373  ? 763 ALA A N   1 
ATOM   2466 C CA  . ALA A 1 325 ? 129.936 104.761 104.918 1 70.03   ? 763 ALA A CA  1 
ATOM   2467 C C   . ALA A 1 325 ? 130.129 104.268 106.361 1 75.352  ? 763 ALA A C   1 
ATOM   2468 O O   . ALA A 1 325 ? 131.252 104.034 106.787 1 73.813  ? 763 ALA A O   1 
ATOM   2469 C CB  . ALA A 1 325 ? 129.825 106.247 104.881 1 68.066  ? 763 ALA A CB  1 
ATOM   2470 N N   . CYS A 1 326 ? 129.043 104.087 107.12  1 72.465  ? 764 CYS A N   1 
ATOM   2471 C CA  . CYS A 1 326 ? 129.115 103.895 108.562 1 70.038  ? 764 CYS A CA  1 
ATOM   2472 C C   . CYS A 1 326 ? 128.942 102.437 108.977 1 62.246  ? 764 CYS A C   1 
ATOM   2473 O O   . CYS A 1 326 ? 128.656 102.16  110.129 1 68.8    ? 764 CYS A O   1 
ATOM   2474 C CB  . CYS A 1 326 ? 128.049 104.736 109.266 1 67.43   ? 764 CYS A CB  1 
ATOM   2475 S SG  . CYS A 1 326 ? 128.38  106.509 109.078 1 80.089  ? 764 CYS A SG  1 
ATOM   2476 N N   . GLY A 1 327 ? 129.075 101.495 108.059 1 55.406  ? 765 GLY A N   1 
ATOM   2477 C CA  . GLY A 1 327 ? 129.063 100.097 108.457 1 57.616  ? 765 GLY A CA  1 
ATOM   2478 C C   . GLY A 1 327 ? 127.68  99.528  108.754 1 64.727  ? 765 GLY A C   1 
ATOM   2479 O O   . GLY A 1 327 ? 127.581 98.465  109.355 1 67.412  ? 765 GLY A O   1 
ATOM   2480 N N   . GLN A 1 328 ? 126.613 100.218 108.337 1 64.125  ? 766 GLN A N   1 
ATOM   2481 C CA  . GLN A 1 328 ? 125.267 99.705  108.549 1 62.058  ? 766 GLN A CA  1 
ATOM   2482 C C   . GLN A 1 328 ? 124.957 98.623  107.519 1 62.855  ? 766 GLN A C   1 
ATOM   2483 O O   . GLN A 1 328 ? 125.596 98.506  106.478 1 74.182  ? 766 GLN A O   1 
ATOM   2484 C CB  . GLN A 1 328 ? 124.247 100.826 108.425 1 62.156  ? 766 GLN A CB  1 
ATOM   2485 C CG  . GLN A 1 328 ? 124.628 102.075 109.202 1 66.81   ? 766 GLN A CG  1 
ATOM   2486 C CD  . GLN A 1 328 ? 124.842 101.779 110.665 1 62.445  ? 766 GLN A CD  1 
ATOM   2487 O OE1 . GLN A 1 328 ? 124.055 101.047 111.248 1 61.16   ? 766 GLN A OE1 1 
ATOM   2488 N NE2 . GLN A 1 328 ? 125.896 102.324 111.249 1 70.638  ? 766 GLN A NE2 1 
ATOM   2489 N N   . ASP A 1 329 ? 123.968 97.807  107.818 1 66.392  ? 767 ASP A N   1 
ATOM   2490 C CA  . ASP A 1 329 ? 123.489 96.831  106.854 1 70.355  ? 767 ASP A CA  1 
ATOM   2491 C C   . ASP A 1 329 ? 122.701 97.536  105.745 1 74.004  ? 767 ASP A C   1 
ATOM   2492 O O   . ASP A 1 329 ? 121.614 98.047  105.988 1 76.185  ? 767 ASP A O   1 
ATOM   2493 C CB  . ASP A 1 329 ? 122.614 95.838  107.578 1 78.249  ? 767 ASP A CB  1 
ATOM   2494 C CG  . ASP A 1 329 ? 122.007 94.794  106.678 1 91.6    ? 767 ASP A CG  1 
ATOM   2495 O OD1 . ASP A 1 329 ? 122.56  94.572  105.563 1 106.03  ? 767 ASP A OD1 1 
ATOM   2496 O OD2 . ASP A 1 329 ? 121     94.225  107.113 1 97.666  ? 767 ASP A OD2 1 
ATOM   2497 N N   . ALA A 1 330 ? 123.258 97.602  104.536 1 71.913  ? 768 ALA A N   1 
ATOM   2498 C CA  . ALA A 1 330 ? 122.721 98.469  103.49  1 71.292  ? 768 ALA A CA  1 
ATOM   2499 C C   . ALA A 1 330 ? 121.364 97.988  102.943 1 64.687  ? 768 ALA A C   1 
ATOM   2500 O O   . ALA A 1 330 ? 120.534 98.796  102.562 1 65.583  ? 768 ALA A O   1 
ATOM   2501 C CB  . ALA A 1 330 ? 123.703 98.595  102.36  1 76.764  ? 768 ALA A CB  1 
ATOM   2502 N N   . ALA A 1 331 ? 121.091 96.683  102.988 1 63.457  ? 769 ALA A N   1 
ATOM   2503 C CA  . ALA A 1 331 ? 119.784 96.184  102.611 1 63.911  ? 769 ALA A CA  1 
ATOM   2504 C C   . ALA A 1 331 ? 118.663 96.859  103.42  1 74.607  ? 769 ALA A C   1 
ATOM   2505 O O   . ALA A 1 331 ? 117.57  97.103  102.907 1 71.444  ? 769 ALA A O   1 
ATOM   2506 C CB  . ALA A 1 331 ? 119.758 94.693  102.752 1 60.25   ? 769 ALA A CB  1 
ATOM   2507 N N   . GLN A 1 332 ? 118.961 97.229  104.662 1 62.723  ? 770 GLN A N   1 
ATOM   2508 C CA  . GLN A 1 332 ? 117.974 97.819  105.545 1 70.436  ? 770 GLN A CA  1 
ATOM   2509 C C   . GLN A 1 332 ? 117.469 99.151  105.029 1 66.451  ? 770 GLN A C   1 
ATOM   2510 O O   . GLN A 1 332 ? 116.426 99.63   105.473 1 69.091  ? 770 GLN A O   1 
ATOM   2511 C CB  . GLN A 1 332 ? 118.473 97.905  106.986 1 72.605  ? 770 GLN A CB  1 
ATOM   2512 C CG  . GLN A 1 332 ? 118.761 96.508  107.535 1 88.453  ? 770 GLN A CG  1 
ATOM   2513 C CD  . GLN A 1 332 ? 118.609 96.405  109.03  1 94.58   ? 770 GLN A CD  1 
ATOM   2514 O OE1 . GLN A 1 332 ? 117.754 95.681  109.54  1 86.043  ? 770 GLN A OE1 1 
ATOM   2515 N NE2 . GLN A 1 332 ? 119.456 97.127  109.751 1 100.159 ? 770 GLN A NE2 1 
ATOM   2516 N N   . ASN A 1 333 ? 118.161 99.719  104.053 1 64.906  ? 771 ASN A N   1 
ATOM   2517 C CA  . ASN A 1 333 ? 117.67  100.952 103.475 1 71.93   ? 771 ASN A CA  1 
ATOM   2518 C C   . ASN A 1 333 ? 116.254 100.779 102.927 1 67.686  ? 771 ASN A C   1 
ATOM   2519 O O   . ASN A 1 333 ? 115.451 101.705 102.979 1 71.755  ? 771 ASN A O   1 
ATOM   2520 C CB  . ASN A 1 333 ? 118.619 101.473 102.414 1 73.303  ? 771 ASN A CB  1 
ATOM   2521 C CG  . ASN A 1 333 ? 118.559 100.681 101.143 1 92.448  ? 771 ASN A CG  1 
ATOM   2522 O OD1 . ASN A 1 333 ? 118.393 99.45   101.156 1 88.395  ? 771 ASN A OD1 1 
ATOM   2523 N ND2 . ASN A 1 333 ? 118.646 101.4   100.033 1 95.612  ? 771 ASN A ND2 1 
ATOM   2524 N N   . VAL A 1 334 ? 115.954 99.577  102.465 1 62.56   ? 772 VAL A N   1 
ATOM   2525 C CA  . VAL A 1 334 ? 114.62  99.249  102.008 1 73.127  ? 772 VAL A CA  1 
ATOM   2526 C C   . VAL A 1 334 ? 113.58  99.764  103.004 1 79.699  ? 772 VAL A C   1 
ATOM   2527 O O   . VAL A 1 334 ? 112.655 100.489 102.648 1 82.697  ? 772 VAL A O   1 
ATOM   2528 C CB  . VAL A 1 334 ? 114.468 97.74   101.77  1 76.247  ? 772 VAL A CB  1 
ATOM   2529 C CG1 . VAL A 1 334 ? 113.03  97.297  101.864 1 85.524  ? 772 VAL A CG1 1 
ATOM   2530 C CG2 . VAL A 1 334 ? 115.024 97.306  100.428 1 76.446  ? 772 VAL A CG2 1 
ATOM   2531 N N   . GLY A 1 335 ? 113.718 99.413  104.269 1 74.708  ? 773 GLY A N   1 
ATOM   2532 C CA  . GLY A 1 335 ? 112.789 99.972  105.23  1 68.766  ? 773 GLY A CA  1 
ATOM   2533 C C   . GLY A 1 335 ? 113.189 101.335 105.778 1 68.079  ? 773 GLY A C   1 
ATOM   2534 O O   . GLY A 1 335 ? 112.32  102.12  106.152 1 77.405  ? 773 GLY A O   1 
ATOM   2535 N N   . SER A 1 336 ? 114.478 101.646 105.82  1 64.351  ? 774 SER A N   1 
ATOM   2536 C CA  . SER A 1 336 ? 114.908 102.831 106.548 1 62.998  ? 774 SER A CA  1 
ATOM   2537 C C   . SER A 1 336 ? 114.687 104.108 105.758 1 59.884  ? 774 SER A C   1 
ATOM   2538 O O   . SER A 1 336 ? 114.751 105.19  106.32  1 69.962  ? 774 SER A O   1 
ATOM   2539 C CB  . SER A 1 336 ? 116.373 102.722 106.94  1 63.899  ? 774 SER A CB  1 
ATOM   2540 O OG  . SER A 1 336 ? 116.607 101.569 107.738 1 59.557  ? 774 SER A OG  1 
ATOM   2541 N N   . SER A 1 337 ? 114.47  104.014 104.448 1 61.95   ? 775 SER A N   1 
ATOM   2542 C CA  . SER A 1 337 ? 114.315 105.21  103.646 1 64.113  ? 775 SER A CA  1 
ATOM   2543 C C   . SER A 1 337 ? 112.872 105.737 103.652 1 57.808  ? 775 SER A C   1 
ATOM   2544 O O   . SER A 1 337 ? 112.605 106.749 103.019 1 64.9    ? 775 SER A O   1 
ATOM   2545 C CB  . SER A 1 337 ? 114.821 104.91  102.237 1 62.766  ? 775 SER A CB  1 
ATOM   2546 O OG  . SER A 1 337 ? 114.422 103.611 101.807 1 79.698  ? 775 SER A OG  1 
ATOM   2547 N N   . ASN A 1 338 ? 111.927 105.03  104.26  1 51.783  ? 776 ASN A N   1 
ATOM   2548 C CA  . ASN A 1 338 ? 110.562 105.523 104.397 1 54.13   ? 776 ASN A CA  1 
ATOM   2549 C C   . ASN A 1 338 ? 110.588 106.924 104.984 1 57.432  ? 776 ASN A C   1 
ATOM   2550 O O   . ASN A 1 338 ? 111.168 107.176 106.045 1 69.373  ? 776 ASN A O   1 
ATOM   2551 C CB  . ASN A 1 338 ? 109.707 104.656 105.321 1 60.429  ? 776 ASN A CB  1 
ATOM   2552 C CG  . ASN A 1 338 ? 109.325 103.319 104.747 1 66.448  ? 776 ASN A CG  1 
ATOM   2553 O OD1 . ASN A 1 338 ? 109.483 103.062 103.543 1 69.685  ? 776 ASN A OD1 1 
ATOM   2554 N ND2 . ASN A 1 338 ? 108.799 102.468 105.62  1 69.497  ? 776 ASN A ND2 1 
ATOM   2555 N N   . CYS A 1 339 ? 109.973 107.855 104.27  1 50.531  ? 777 CYS A N   1 
ATOM   2556 C CA  . CYS A 1 339 ? 110.05  109.24  104.67  1 59.658  ? 777 CYS A CA  1 
ATOM   2557 C C   . CYS A 1 339 ? 108.905 110.002 104.028 1 55.255  ? 777 CYS A C   1 
ATOM   2558 O O   . CYS A 1 339 ? 108.516 109.7   102.911 1 62.548  ? 777 CYS A O   1 
ATOM   2559 C CB  . CYS A 1 339 ? 111.4   109.859 104.287 1 58.665  ? 777 CYS A CB  1 
ATOM   2560 S SG  . CYS A 1 339 ? 111.495 111.656 104.454 1 65.491  ? 777 CYS A SG  1 
ATOM   2561 N N   . ILE A 1 340 ? 108.425 111.008 104.741 1 48.871  ? 778 ILE A N   1 
ATOM   2562 C CA  . ILE A 1 340 ? 107.519 111.976 104.183 1 52.779  ? 778 ILE A CA  1 
ATOM   2563 C C   . ILE A 1 340 ? 108.12  113.359 104.378 1 52.219  ? 778 ILE A C   1 
ATOM   2564 O O   . ILE A 1 340 ? 108.559 113.687 105.473 1 56.205  ? 778 ILE A O   1 
ATOM   2565 C CB  . ILE A 1 340 ? 106.105 111.894 104.795 1 61.875  ? 778 ILE A CB  1 
ATOM   2566 C CG1 . ILE A 1 340 ? 105.218 112.979 104.165 1 61.356  ? 778 ILE A CG1 1 
ATOM   2567 C CG2 . ILE A 1 340 ? 106.104 111.987 106.337 1 59.292  ? 778 ILE A CG2 1 
ATOM   2568 C CD1 . ILE A 1 340 ? 103.73  112.696 104.248 1 65.271  ? 778 ILE A CD1 1 
ATOM   2569 N N   . THR A 1 341 ? 108.171 114.117 103.287 1 54.691  ? 779 THR A N   1 
ATOM   2570 C CA  . THR A 1 341 ? 108.749 115.452 103.265 1 59.06   ? 779 THR A CA  1 
ATOM   2571 C C   . THR A 1 341 ? 107.62  116.457 103.094 1 55.19   ? 779 THR A C   1 
ATOM   2572 O O   . THR A 1 341 ? 106.845 116.34  102.152 1 63.072  ? 779 THR A O   1 
ATOM   2573 C CB  . THR A 1 341 ? 109.731 115.578 102.092 1 68.873  ? 779 THR A CB  1 
ATOM   2574 O OG1 . THR A 1 341 ? 110.79  114.641 102.259 1 67.409  ? 779 THR A OG1 1 
ATOM   2575 C CG2 . THR A 1 341 ? 110.344 116.963 102.014 1 71.926  ? 779 THR A CG2 1 
ATOM   2576 N N   . LEU A 1 342 ? 107.552 117.445 103.983 1 57.123  ? 780 LEU A N   1 
ATOM   2577 C CA  . LEU A 1 342 ? 106.514 118.463 103.927 1 59.971  ? 780 LEU A CA  1 
ATOM   2578 C C   . LEU A 1 342 ? 107.153 119.835 103.877 1 60.735  ? 780 LEU A C   1 
ATOM   2579 O O   . LEU A 1 342 ? 108.116 120.101 104.598 1 68.941  ? 780 LEU A O   1 
ATOM   2580 C CB  . LEU A 1 342 ? 105.566 118.354 105.119 1 62.571  ? 780 LEU A CB  1 
ATOM   2581 C CG  . LEU A 1 342 ? 104.822 117.021 105.231 1 62.271  ? 780 LEU A CG  1 
ATOM   2582 C CD1 . LEU A 1 342 ? 103.969 117.017 106.442 1 63.749  ? 780 LEU A CD1 1 
ATOM   2583 C CD2 . LEU A 1 342 ? 103.981 116.73  103.98  1 71.492  ? 780 LEU A CD2 1 
ATOM   2584 N N   . MET A 1 343 ? 106.611 120.687 103.009 1 60.802  ? 781 MET A N   1 
ATOM   2585 C CA  . MET A 1 343 ? 107.058 122.058 102.892 1 62.672  ? 781 MET A CA  1 
ATOM   2586 C C   . MET A 1 343 ? 105.869 123     103.025 1 65.645  ? 781 MET A C   1 
ATOM   2587 O O   . MET A 1 343 ? 104.813 122.741 102.467 1 84.24   ? 781 MET A O   1 
ATOM   2588 C CB  . MET A 1 343 ? 107.767 122.283 101.559 1 66.428  ? 781 MET A CB  1 
ATOM   2589 C CG  . MET A 1 343 ? 108.902 121.317 101.306 1 72.138  ? 781 MET A CG  1 
ATOM   2590 S SD  . MET A 1 343 ? 109.878 121.814 99.871  1 76.117  ? 781 MET A SD  1 
ATOM   2591 C CE  . MET A 1 343 ? 110.924 120.357 99.702  1 84.383  ? 781 MET A CE  1 
ATOM   2592 N N   . GLU A 1 344 ? 106.062 124.107 103.739 1 67.348  ? 782 GLU A N   1 
ATOM   2593 C CA  . GLU A 1 344 ? 105.012 125.093 103.906 1 70.995  ? 782 GLU A CA  1 
ATOM   2594 C C   . GLU A 1 344 ? 105.624 126.49  103.899 1 65.453  ? 782 GLU A C   1 
ATOM   2595 O O   . GLU A 1 344 ? 106.83  126.648 103.993 1 70.096  ? 782 GLU A O   1 
ATOM   2596 C CB  . GLU A 1 344 ? 104.216 124.934 105.202 1 70.264  ? 782 GLU A CB  1 
ATOM   2597 C CG  . GLU A 1 344 ? 103.854 123.495 105.554 1 90.188  ? 782 GLU A CG  1 
ATOM   2598 C CD  . GLU A 1 344 ? 103.282 123.342 106.96  1 106.014 ? 782 GLU A CD  1 
ATOM   2599 O OE1 . GLU A 1 344 ? 102.936 124.372 107.593 1 101.929 ? 782 GLU A OE1 1 
ATOM   2600 O OE2 . GLU A 1 344 ? 103.209 122.181 107.437 1 104.301 ? 782 GLU A OE2 1 
ATOM   2601 N N   . ALA A 1 345 ? 104.763 127.496 103.743 1 71.609  ? 783 ALA A N   1 
ATOM   2602 C CA  . ALA A 1 345 ? 105.163 128.879 103.892 1 76.965  ? 783 ALA A CA  1 
ATOM   2603 C C   . ALA A 1 345 ? 105.185 129.211 105.375 1 71.71   ? 783 ALA A C   1 
ATOM   2604 O O   . ALA A 1 345 ? 104.431 128.648 106.161 1 83.718  ? 783 ALA A O   1 
ATOM   2605 C CB  . ALA A 1 345 ? 104.245 129.811 103.136 1 78.281  ? 783 ALA A CB  1 
ATOM   2606 N N   . SER A 1 346 ? 106.058 130.147 105.747 1 73.615  ? 784 SER A N   1 
ATOM   2607 C CA  . SER A 1 346 ? 106.217 130.491 107.143 1 72.415  ? 784 SER A CA  1 
ATOM   2608 C C   . SER A 1 346 ? 106.823 131.879 107.246 1 71.274  ? 784 SER A C   1 
ATOM   2609 O O   . SER A 1 346 ? 107.282 132.441 106.253 1 75.27   ? 784 SER A O   1 
ATOM   2610 C CB  . SER A 1 346 ? 107.031 129.446 107.871 1 83.288  ? 784 SER A CB  1 
ATOM   2611 O OG  . SER A 1 346 ? 108.404 129.775 107.864 1 83.081  ? 784 SER A OG  1 
ATOM   2612 N N   . GLY A 1 347 ? 106.807 132.409 108.471 1 83.205  ? 785 GLY A N   1 
ATOM   2613 C CA  . GLY A 1 347 ? 107.303 133.746 108.743 1 84.109  ? 785 GLY A CA  1 
ATOM   2614 C C   . GLY A 1 347 ? 106.157 134.743 108.808 1 92.647  ? 785 GLY A C   1 
ATOM   2615 O O   . GLY A 1 347 ? 105.013 134.421 108.5   1 97.77   ? 785 GLY A O   1 
ATOM   2616 N N   . PRO A 1 348 ? 106.435 135.998 109.218 1 106.553 ? 786 PRO A N   1 
ATOM   2617 C CA  . PRO A 1 348 ? 105.409 137.029 109.271 1 101.728 ? 786 PRO A CA  1 
ATOM   2618 C C   . PRO A 1 348 ? 104.825 137.417 107.915 1 105.294 ? 786 PRO A C   1 
ATOM   2619 O O   . PRO A 1 348 ? 103.832 138.14  107.868 1 121.786 ? 786 PRO A O   1 
ATOM   2620 C CB  . PRO A 1 348 ? 106.147 138.202 109.909 1 106.887 ? 786 PRO A CB  1 
ATOM   2621 C CG  . PRO A 1 348 ? 107.585 137.959 109.501 1 104.787 ? 786 PRO A CG  1 
ATOM   2622 C CD  . PRO A 1 348 ? 107.755 136.492 109.645 1 103.581 ? 786 PRO A CD  1 
ATOM   2623 N N   . THR A 1 349 ? 105.43  136.941 106.817 1 102.104 ? 787 THR A N   1 
ATOM   2624 C CA  . THR A 1 349 ? 104.984 137.314 105.479 1 96.902  ? 787 THR A CA  1 
ATOM   2625 C C   . THR A 1 349 ? 104.65  136.083 104.622 1 95.088  ? 787 THR A C   1 
ATOM   2626 O O   . THR A 1 349 ? 104.253 136.225 103.469 1 94.002  ? 787 THR A O   1 
ATOM   2627 C CB  . THR A 1 349 ? 106.076 138.178 104.844 1 112.433 ? 787 THR A CB  1 
ATOM   2628 O OG1 . THR A 1 349 ? 105.937 139.506 105.355 1 110.434 ? 787 THR A OG1 1 
ATOM   2629 C CG2 . THR A 1 349 ? 105.975 138.256 103.331 1 127.197 ? 787 THR A CG2 1 
ATOM   2630 N N   . ASN A 1 350 ? 104.779 134.874 105.18  1 94.211  ? 788 ASN A N   1 
ATOM   2631 C CA  . ASN A 1 350 ? 104.582 133.65  104.416 1 93.245  ? 788 ASN A CA  1 
ATOM   2632 C C   . ASN A 1 350 ? 105.592 133.563 103.278 1 87.211  ? 788 ASN A C   1 
ATOM   2633 O O   . ASN A 1 350 ? 105.317 132.93  102.258 1 94.579  ? 788 ASN A O   1 
ATOM   2634 C CB  . ASN A 1 350 ? 103.16  133.521 103.872 1 93.461  ? 788 ASN A CB  1 
ATOM   2635 C CG  . ASN A 1 350 ? 102.188 133.058 104.928 1 93.369  ? 788 ASN A CG  1 
ATOM   2636 O OD1 . ASN A 1 350 ? 101.483 133.882 105.519 1 118.457 ? 788 ASN A OD1 1 
ATOM   2637 N ND2 . ASN A 1 350 ? 102.147 131.761 105.191 1 106.062 ? 788 ASN A ND2 1 
ATOM   2638 N N   . GLU A 1 351 ? 106.778 134.146 103.477 1 79.428  ? 789 GLU A N   1 
ATOM   2639 C CA  . GLU A 1 351 ? 107.8   134.122 102.444 1 82.039  ? 789 GLU A CA  1 
ATOM   2640 C C   . GLU A 1 351 ? 108.902 133.093 102.713 1 72.714  ? 789 GLU A C   1 
ATOM   2641 O O   . GLU A 1 351 ? 109.601 132.713 101.784 1 76.717  ? 789 GLU A O   1 
ATOM   2642 C CB  . GLU A 1 351 ? 108.425 135.502 102.283 1 100.001 ? 789 GLU A CB  1 
ATOM   2643 C CG  . GLU A 1 351 ? 107.991 136.229 101.013 1 118.76  ? 789 GLU A CG  1 
ATOM   2644 C CD  . GLU A 1 351 ? 108.958 137.362 100.668 1 146.567 ? 789 GLU A CD  1 
ATOM   2645 O OE1 . GLU A 1 351 ? 109.422 137.459 99.498  1 125.429 ? 789 GLU A OE1 1 
ATOM   2646 O OE2 . GLU A 1 351 ? 109.286 138.135 101.605 1 142.42  ? 789 GLU A OE2 1 
ATOM   2647 N N   . ASP A 1 352 ? 109.07  132.645 103.961 1 69.759  ? 790 ASP A N   1 
ATOM   2648 C CA  . ASP A 1 352 ? 110.124 131.705 104.301 1 73.339  ? 790 ASP A CA  1 
ATOM   2649 C C   . ASP A 1 352 ? 109.635 130.276 104.114 1 71.543  ? 790 ASP A C   1 
ATOM   2650 O O   . ASP A 1 352 ? 108.445 130.009 104.173 1 73.076  ? 790 ASP A O   1 
ATOM   2651 C CB  . ASP A 1 352 ? 110.605 131.92  105.721 1 71.478  ? 790 ASP A CB  1 
ATOM   2652 C CG  . ASP A 1 352 ? 110.818 133.384 106.066 1 87.14   ? 790 ASP A CG  1 
ATOM   2653 O OD1 . ASP A 1 352 ? 111.406 134.105 105.226 1 85.771  ? 790 ASP A OD1 1 
ATOM   2654 O OD2 . ASP A 1 352 ? 110.391 133.798 107.167 1 103.237 ? 790 ASP A OD2 1 
ATOM   2655 N N   . LEU A 1 353 ? 110.575 129.359 103.916 1 64.064  ? 791 LEU A N   1 
ATOM   2656 C CA  . LEU A 1 353 ? 110.255 127.986 103.617 1 66.476  ? 791 LEU A CA  1 
ATOM   2657 C C   . LEU A 1 353 ? 110.447 127.149 104.87  1 71.047  ? 791 LEU A C   1 
ATOM   2658 O O   . LEU A 1 353 ? 111.571 126.913 105.281 1 78.581  ? 791 LEU A O   1 
ATOM   2659 C CB  . LEU A 1 353 ? 111.133 127.466 102.476 1 64.837  ? 791 LEU A CB  1 
ATOM   2660 C CG  . LEU A 1 353 ? 110.899 126.01  102.09  1 71.076  ? 791 LEU A CG  1 
ATOM   2661 C CD1 . LEU A 1 353 ? 109.522 125.869 101.462 1 76.262  ? 791 LEU A CD1 1 
ATOM   2662 C CD2 . LEU A 1 353 ? 111.997 125.517 101.187 1 72.559  ? 791 LEU A CD2 1 
ATOM   2663 N N   . TYR A 1 354 ? 109.354 126.631 105.419 1 66.802  ? 792 TYR A N   1 
ATOM   2664 C CA  . TYR A 1 354 ? 109.441 125.621 106.449 1 63.194  ? 792 TYR A CA  1 
ATOM   2665 C C   . TYR A 1 354 ? 109.503 124.253 105.783 1 62.866  ? 792 TYR A C   1 
ATOM   2666 O O   . TYR A 1 354 ? 108.723 123.976 104.884 1 70.662  ? 792 TYR A O   1 
ATOM   2667 C CB  . TYR A 1 354 ? 108.24  125.711 107.38  1 70.084  ? 792 TYR A CB  1 
ATOM   2668 C CG  . TYR A 1 354 ? 108.094 124.513 108.294 1 72.222  ? 792 TYR A CG  1 
ATOM   2669 C CD1 . TYR A 1 354 ? 108.747 124.476 109.516 1 78.891  ? 792 TYR A CD1 1 
ATOM   2670 C CD2 . TYR A 1 354 ? 107.325 123.421 107.931 1 81.241  ? 792 TYR A CD2 1 
ATOM   2671 C CE1 . TYR A 1 354 ? 108.609 123.398 110.369 1 74.288  ? 792 TYR A CE1 1 
ATOM   2672 C CE2 . TYR A 1 354 ? 107.177 122.337 108.777 1 78.041  ? 792 TYR A CE2 1 
ATOM   2673 C CZ  . TYR A 1 354 ? 107.82  122.326 110.002 1 77.884  ? 792 TYR A CZ  1 
ATOM   2674 O OH  . TYR A 1 354 ? 107.714 121.245 110.834 1 85.88   ? 792 TYR A OH  1 
ATOM   2675 N N   . ILE A 1 355 ? 110.436 123.413 106.227 1 58.107  ? 793 ILE A N   1 
ATOM   2676 C CA  . ILE A 1 355 ? 110.57  122.068 105.705 1 58.29   ? 793 ILE A CA  1 
ATOM   2677 C C   . ILE A 1 355 ? 110.701 121.118 106.89  1 60.227  ? 793 ILE A C   1 
ATOM   2678 O O   . ILE A 1 355 ? 111.233 121.478 107.924 1 71.406  ? 793 ILE A O   1 
ATOM   2679 C CB  . ILE A 1 355 ? 111.766 121.894 104.756 1 62.727  ? 793 ILE A CB  1 
ATOM   2680 C CG1 . ILE A 1 355 ? 111.857 120.459 104.25  1 64.98   ? 793 ILE A CG1 1 
ATOM   2681 C CG2 . ILE A 1 355 ? 113.08  122.313 105.424 1 64.911  ? 793 ILE A CG2 1 
ATOM   2682 C CD1 . ILE A 1 355 ? 112.872 120.232 103.148 1 70.427  ? 793 ILE A CD1 1 
ATOM   2683 N N   . SER A 1 356 ? 110.131 119.935 106.733 1 57.848  ? 794 SER A N   1 
ATOM   2684 C CA  . SER A 1 356 ? 110.237 118.886 107.715 1 65.795  ? 794 SER A CA  1 
ATOM   2685 C C   . SER A 1 356 ? 110.319 117.539 107.006 1 58.187  ? 794 SER A C   1 
ATOM   2686 O O   . SER A 1 356 ? 109.703 117.333 105.966 1 67.441  ? 794 SER A O   1 
ATOM   2687 C CB  . SER A 1 356 ? 109.116 118.92  108.702 1 64.319  ? 794 SER A CB  1 
ATOM   2688 O OG  . SER A 1 356 ? 107.892 118.604 108.067 1 69.007  ? 794 SER A OG  1 
ATOM   2689 N N   . CYS A 1 357 ? 111.128 116.652 107.583 1 58.115  ? 795 CYS A N   1 
ATOM   2690 C CA  . CYS A 1 357 ? 111.221 115.28  107.142 1 59.44   ? 795 CYS A CA  1 
ATOM   2691 C C   . CYS A 1 357 ? 110.83  114.392 108.316 1 58.123  ? 795 CYS A C   1 
ATOM   2692 O O   . CYS A 1 357 ? 111.255 114.628 109.433 1 60.359  ? 795 CYS A O   1 
ATOM   2693 C CB  . CYS A 1 357 ? 112.62  114.966 106.597 1 69.985  ? 795 CYS A CB  1 
ATOM   2694 S SG  . CYS A 1 357 ? 112.872 115.529 104.887 1 80.721  ? 795 CYS A SG  1 
ATOM   2695 N N   . THR A 1 358 ? 110.026 113.365 108.047 1 59.046  ? 796 THR A N   1 
ATOM   2696 C CA  . THR A 1 358 ? 109.625 112.417 109.068 1 56.583  ? 796 THR A CA  1 
ATOM   2697 C C   . THR A 1 358 ? 109.932 111.023 108.563 1 56.979  ? 796 THR A C   1 
ATOM   2698 O O   . THR A 1 358 ? 109.523 110.651 107.444 1 61.802  ? 796 THR A O   1 
ATOM   2699 C CB  . THR A 1 358 ? 108.135 112.513 109.397 1 63.119  ? 796 THR A CB  1 
ATOM   2700 O OG1 . THR A 1 358 ? 107.812 113.876 109.607 1 62.462  ? 796 THR A OG1 1 
ATOM   2701 C CG2 . THR A 1 358 ? 107.773 111.726 110.638 1 66.022  ? 796 THR A CG2 1 
ATOM   2702 N N   . MET A 1 359 ? 110.694 110.285 109.378 1 56.103  ? 797 MET A N   1 
ATOM   2703 C CA  . MET A 1 359 ? 111.184 108.976 109.01  1 57.71   ? 797 MET A CA  1 
ATOM   2704 C C   . MET A 1 359 ? 110.888 108.039 110.158 1 57.885  ? 797 MET A C   1 
ATOM   2705 O O   . MET A 1 359 ? 111.605 108.028 111.145 1 64.494  ? 797 MET A O   1 
ATOM   2706 C CB  . MET A 1 359 ? 112.692 108.992 108.71  1 57.859  ? 797 MET A CB  1 
ATOM   2707 C CG  . MET A 1 359 ? 113.113 110.134 107.812 1 64.318  ? 797 MET A CG  1 
ATOM   2708 S SD  . MET A 1 359 ? 114.768 109.978 107.106 1 66.882  ? 797 MET A SD  1 
ATOM   2709 C CE  . MET A 1 359 ? 114.76  108.39  106.282 1 61.395  ? 797 MET A CE  1 
ATOM   2710 N N   . PRO A 1 360 ? 109.828 107.22  110.078 1 60.888  ? 798 PRO A N   1 
ATOM   2711 C CA  . PRO A 1 360 ? 109.427 106.426 111.222 1 61.179  ? 798 PRO A CA  1 
ATOM   2712 C C   . PRO A 1 360 ? 110.156 105.121 111.441 1 54.738  ? 798 PRO A C   1 
ATOM   2713 O O   . PRO A 1 360 ? 109.942 104.513 112.478 1 63.569  ? 798 PRO A O   1 
ATOM   2714 C CB  . PRO A 1 360 ? 107.93  106.173 110.953 1 63.16   ? 798 PRO A CB  1 
ATOM   2715 C CG  . PRO A 1 360 ? 107.874 106.133 109.481 1 72.64   ? 798 PRO A CG  1 
ATOM   2716 C CD  . PRO A 1 360 ? 108.868 107.148 108.97  1 63.662  ? 798 PRO A CD  1 
ATOM   2717 N N   . SER A 1 361 ? 110.968 104.661 110.488 1 54.331  ? 799 SER A N   1 
ATOM   2718 C CA  . SER A 1 361 ? 111.526 103.324 110.561 1 56.894  ? 799 SER A CA  1 
ATOM   2719 C C   . SER A 1 361 ? 113.026 103.318 110.256 1 54.816  ? 799 SER A C   1 
ATOM   2720 O O   . SER A 1 361 ? 113.491 102.509 109.461 1 57.77   ? 799 SER A O   1 
ATOM   2721 C CB  . SER A 1 361 ? 110.787 102.343 109.672 1 60.284  ? 799 SER A CB  1 
ATOM   2722 O OG  . SER A 1 361 ? 110.384 102.96  108.462 1 71.061  ? 799 SER A OG  1 
ATOM   2723 N N   . ILE A 1 362 ? 113.796 104.186 110.9   1 56.769  ? 800 ILE A N   1 
ATOM   2724 C CA  . ILE A 1 362 ? 115.242 104.187 110.708 1 62.108  ? 800 ILE A CA  1 
ATOM   2725 C C   . ILE A 1 362 ? 115.886 103.048 111.518 1 65.413  ? 800 ILE A C   1 
ATOM   2726 O O   . ILE A 1 362 ? 115.949 103.102 112.733 1 67.259  ? 800 ILE A O   1 
ATOM   2727 C CB  . ILE A 1 362 ? 115.84  105.543 111.094 1 67.477  ? 800 ILE A CB  1 
ATOM   2728 C CG1 . ILE A 1 362 ? 115.352 106.631 110.167 1 64.646  ? 800 ILE A CG1 1 
ATOM   2729 C CG2 . ILE A 1 362 ? 117.373 105.466 111.131 1 71.167  ? 800 ILE A CG2 1 
ATOM   2730 C CD1 . ILE A 1 362 ? 116.012 107.969 110.4   1 69.502  ? 800 ILE A CD1 1 
ATOM   2731 N N   . GLU A 1 363 ? 116.325 101.998 110.824 1 67.674  ? 801 GLU A N   1 
ATOM   2732 C CA  . GLU A 1 363 ? 116.986 100.848 111.427 1 69.77   ? 801 GLU A CA  1 
ATOM   2733 C C   . GLU A 1 363 ? 118.497 101.074 111.406 1 73.261  ? 801 GLU A C   1 
ATOM   2734 O O   . GLU A 1 363 ? 119.089 101.189 110.336 1 78.433  ? 801 GLU A O   1 
ATOM   2735 C CB  . GLU A 1 363 ? 116.655 99.573  110.655 1 73.187  ? 801 GLU A CB  1 
ATOM   2736 C CG  . GLU A 1 363 ? 115.155 99.325  110.498 1 90.453  ? 801 GLU A CG  1 
ATOM   2737 C CD  . GLU A 1 363 ? 114.664 99.211  109.049 1 108.125 ? 801 GLU A CD  1 
ATOM   2738 O OE1 . GLU A 1 363 ? 113.478 99.526  108.787 1 123.859 ? 801 GLU A OE1 1 
ATOM   2739 O OE2 . GLU A 1 363 ? 115.438 98.813  108.157 1 106.007 ? 801 GLU A OE2 1 
ATOM   2740 N N   . ILE A 1 364 ? 119.11  101.206 112.581 1 68.252  ? 802 ILE A N   1 
ATOM   2741 C CA  . ILE A 1 364 ? 120.463 101.718 112.661 1 66.265  ? 802 ILE A CA  1 
ATOM   2742 C C   . ILE A 1 364 ? 121.095 101.387 114.015 1 69.715  ? 802 ILE A C   1 
ATOM   2743 O O   . ILE A 1 364 ? 120.413 101.255 115.015 1 76.115  ? 802 ILE A O   1 
ATOM   2744 C CB  . ILE A 1 364 ? 120.495 103.22  112.384 1 75.058  ? 802 ILE A CB  1 
ATOM   2745 C CG1 . ILE A 1 364 ? 121.783 103.635 111.699 1 83.831  ? 802 ILE A CG1 1 
ATOM   2746 C CG2 . ILE A 1 364 ? 120.251 104.009 113.667 1 76.264  ? 802 ILE A CG2 1 
ATOM   2747 C CD1 . ILE A 1 364 ? 121.742 105.062 111.208 1 85.097  ? 802 ILE A CD1 1 
ATOM   2748 N N   . GLY A 1 365 ? 122.413 101.227 114.018 1 67.001  ? 803 GLY A N   1 
ATOM   2749 C CA  . GLY A 1 365 ? 123.184 100.879 115.202 1 72.087  ? 803 GLY A CA  1 
ATOM   2750 C C   . GLY A 1 365 ? 124.627 101.371 115.078 1 67.522  ? 803 GLY A C   1 
ATOM   2751 O O   . GLY A 1 365 ? 125.04  101.812 114.013 1 73.612  ? 803 GLY A O   1 
ATOM   2752 N N   . THR A 1 366 ? 125.364 101.369 116.188 1 67.651  ? 804 THR A N   1 
ATOM   2753 C CA  . THR A 1 366 ? 126.761 101.796 116.195 1 67.961  ? 804 THR A CA  1 
ATOM   2754 C C   . THR A 1 366 ? 127.655 100.762 116.868 1 66.794  ? 804 THR A C   1 
ATOM   2755 O O   . THR A 1 366 ? 128.786 101.045 117.163 1 72.651  ? 804 THR A O   1 
ATOM   2756 C CB  . THR A 1 366 ? 126.912 103.149 116.882 1 71.383  ? 804 THR A CB  1 
ATOM   2757 O OG1 . THR A 1 366 ? 126.544 103.021 118.248 1 68.581  ? 804 THR A OG1 1 
ATOM   2758 C CG2 . THR A 1 366 ? 126.089 104.221 116.19  1 70.497  ? 804 THR A CG2 1 
ATOM   2759 N N   . VAL A 1 367 ? 127.159 99.542  117.047 1 69.518  ? 805 VAL A N   1 
ATOM   2760 C CA  . VAL A 1 367 ? 127.923 98.446  117.601 1 70.859  ? 805 VAL A CA  1 
ATOM   2761 C C   . VAL A 1 367 ? 127.485 97.188  116.862 1 69.908  ? 805 VAL A C   1 
ATOM   2762 O O   . VAL A 1 367 ? 126.311 97.014  116.53  1 82.131  ? 805 VAL A O   1 
ATOM   2763 C CB  . VAL A 1 367 ? 127.636 98.311  119.111 1 80.299  ? 805 VAL A CB  1 
ATOM   2764 C CG1 . VAL A 1 367 ? 128.135 97.005  119.689 1 85.808  ? 805 VAL A CG1 1 
ATOM   2765 C CG2 . VAL A 1 367 ? 128.206 99.474  119.878 1 84.974  ? 805 VAL A CG2 1 
ATOM   2766 N N   . GLY A 1 368 ? 128.445 96.301  116.651 1 73.759  ? 806 GLY A N   1 
ATOM   2767 C CA  . GLY A 1 368 ? 128.17  95.022  116.038 1 75.741  ? 806 GLY A CA  1 
ATOM   2768 C C   . GLY A 1 368 ? 128.083 95.123  114.524 1 78.339  ? 806 GLY A C   1 
ATOM   2769 O O   . GLY A 1 368 ? 127.958 96.208  113.951 1 71.75   ? 806 GLY A O   1 
ATOM   2770 N N   . GLY A 1 369 ? 128.189 93.957  113.883 1 83.916  ? 807 GLY A N   1 
ATOM   2771 C CA  . GLY A 1 369 ? 128.13  93.879  112.437 1 76.575  ? 807 GLY A CA  1 
ATOM   2772 C C   . GLY A 1 369 ? 129.246 94.703  111.796 1 77.792  ? 807 GLY A C   1 
ATOM   2773 O O   . GLY A 1 369 ? 130.375 94.759  112.28  1 81.83   ? 807 GLY A O   1 
ATOM   2774 N N   . GLY A 1 370 ? 128.903 95.361  110.694 1 69.234  ? 808 GLY A N   1 
ATOM   2775 C CA  . GLY A 1 370 ? 129.853 96.132  109.926 1 65.777  ? 808 GLY A CA  1 
ATOM   2776 C C   . GLY A 1 370 ? 130.51  97.244  110.735 1 68.89   ? 808 GLY A C   1 
ATOM   2777 O O   . GLY A 1 370 ? 131.572 97.681  110.36  1 71.418  ? 808 GLY A O   1 
ATOM   2778 N N   . THR A 1 371 ? 129.92  97.691  111.842 1 71.349  ? 809 THR A N   1 
ATOM   2779 C CA  . THR A 1 371 ? 130.53  98.737  112.652 1 74.71   ? 809 THR A CA  1 
ATOM   2780 C C   . THR A 1 371 ? 131.739 98.212  113.425 1 66.817  ? 809 THR A C   1 
ATOM   2781 O O   . THR A 1 371 ? 132.353 98.991  114.141 1 69.913  ? 809 THR A O   1 
ATOM   2782 C CB  . THR A 1 371 ? 129.544 99.357  113.651 1 74.43   ? 809 THR A CB  1 
ATOM   2783 O OG1 . THR A 1 371 ? 129.442 98.526  114.8   1 73.23   ? 809 THR A OG1 1 
ATOM   2784 C CG2 . THR A 1 371 ? 128.151 99.47   113.107 1 84.358  ? 809 THR A CG2 1 
ATOM   2785 N N   . ASN A 1 372 ? 132.078 96.928  113.314 1 72.411  ? 810 ASN A N   1 
ATOM   2786 C CA  . ASN A 1 372 ? 133.258 96.396  113.984 1 77.729  ? 810 ASN A CA  1 
ATOM   2787 C C   . ASN A 1 372 ? 134.542 96.566  113.165 1 79.126  ? 810 ASN A C   1 
ATOM   2788 O O   . ASN A 1 372 ? 135.609 96.205  113.651 1 95.419  ? 810 ASN A O   1 
ATOM   2789 C CB  . ASN A 1 372 ? 133.086 94.914  114.316 1 87.897  ? 810 ASN A CB  1 
ATOM   2790 C CG  . ASN A 1 372 ? 132.068 94.679  115.406 1 90.552  ? 810 ASN A CG  1 
ATOM   2791 O OD1 . ASN A 1 372 ? 131.932 95.51   116.312 1 105.415 ? 810 ASN A OD1 1 
ATOM   2792 N ND2 . ASN A 1 372 ? 131.346 93.566  115.346 1 96.065  ? 810 ASN A ND2 1 
ATOM   2793 N N   . LEU A 1 373 ? 134.464 97.086  111.933 1 78.9    ? 811 LEU A N   1 
ATOM   2794 C CA  . LEU A 1 373 ? 135.634 97.235  111.077 1 72.812  ? 811 LEU A CA  1 
ATOM   2795 C C   . LEU A 1 373 ? 136.169 98.657  111.206 1 65.738  ? 811 LEU A C   1 
ATOM   2796 O O   . LEU A 1 373 ? 135.411 99.618  111.293 1 71.735  ? 811 LEU A O   1 
ATOM   2797 C CB  . LEU A 1 373 ? 135.265 96.923  109.63  1 68.634  ? 811 LEU A CB  1 
ATOM   2798 C CG  . LEU A 1 373 ? 134.446 95.647  109.42  1 72.055  ? 811 LEU A CG  1 
ATOM   2799 C CD1 . LEU A 1 373 ? 134.054 95.459  107.969 1 74.598  ? 811 LEU A CD1 1 
ATOM   2800 C CD2 . LEU A 1 373 ? 135.2   94.442  109.91  1 73.625  ? 811 LEU A CD2 1 
ATOM   2801 N N   . LEU A 1 374 ? 137.494 98.793  111.162 1 69.827  ? 812 LEU A N   1 
ATOM   2802 C CA  . LEU A 1 374 ? 138.125 100.059 111.492 1 68.778  ? 812 LEU A CA  1 
ATOM   2803 C C   . LEU A 1 374 ? 137.742 101.142 110.497 1 69.317  ? 812 LEU A C   1 
ATOM   2804 O O   . LEU A 1 374 ? 137.484 102.279 110.891 1 77.89   ? 812 LEU A O   1 
ATOM   2805 C CB  . LEU A 1 374 ? 139.639 99.91   111.571 1 76.702  ? 812 LEU A CB  1 
ATOM   2806 C CG  . LEU A 1 374 ? 140.156 98.984  112.678 1 82.088  ? 812 LEU A CG  1 
ATOM   2807 C CD1 . LEU A 1 374 ? 141.663 99.065  112.769 1 85.181  ? 812 LEU A CD1 1 
ATOM   2808 C CD2 . LEU A 1 374 ? 139.554 99.324  114.007 1 82.53   ? 812 LEU A CD2 1 
ATOM   2809 N N   . PRO A 1 375 ? 137.735 100.886 109.174 1 64.861  ? 813 PRO A N   1 
ATOM   2810 C CA  . PRO A 1 375 ? 137.371 101.951 108.249 1 69.881  ? 813 PRO A CA  1 
ATOM   2811 C C   . PRO A 1 375 ? 135.968 102.501 108.499 1 69.162  ? 813 PRO A C   1 
ATOM   2812 O O   . PRO A 1 375 ? 135.779 103.707 108.514 1 65.399  ? 813 PRO A O   1 
ATOM   2813 C CB  . PRO A 1 375 ? 137.535 101.314 106.874 1 64.974  ? 813 PRO A CB  1 
ATOM   2814 C CG  . PRO A 1 375 ? 138.461 100.127 107.13  1 59.705  ? 813 PRO A CG  1 
ATOM   2815 C CD  . PRO A 1 375 ? 138.106 99.635  108.496 1 61.702  ? 813 PRO A CD  1 
ATOM   2816 N N   . GLN A 1 376 ? 134.983 101.626 108.743 1 65.482  ? 814 GLN A N   1 
ATOM   2817 C CA  . GLN A 1 376 ? 133.652 102.106 109.069 1 66.218  ? 814 GLN A CA  1 
ATOM   2818 C C   . GLN A 1 376 ? 133.613 102.813 110.422 1 67.076  ? 814 GLN A C   1 
ATOM   2819 O O   . GLN A 1 376 ? 132.866 103.783 110.616 1 68.29   ? 814 GLN A O   1 
ATOM   2820 C CB  . GLN A 1 376 ? 132.633 100.977 109.032 1 69.741  ? 814 GLN A CB  1 
ATOM   2821 C CG  . GLN A 1 376 ? 132.364 100.43  107.641 1 68.08   ? 814 GLN A CG  1 
ATOM   2822 C CD  . GLN A 1 376 ? 133.47  99.55   107.118 1 67.355  ? 814 GLN A CD  1 
ATOM   2823 O OE1 . GLN A 1 376 ? 134.625 99.597  107.58  1 76.278  ? 814 GLN A OE1 1 
ATOM   2824 N NE2 . GLN A 1 376 ? 133.099 98.759  106.126 1 65.366  ? 814 GLN A NE2 1 
ATOM   2825 N N   . GLN A 1 377 ? 134.419 102.323 111.365 1 67.242  ? 815 GLN A N   1 
ATOM   2826 C CA  . GLN A 1 377 ? 134.536 102.972 112.663 1 67.418  ? 815 GLN A CA  1 
ATOM   2827 C C   . GLN A 1 377 ? 135.059 104.389 112.525 1 66.752  ? 815 GLN A C   1 
ATOM   2828 O O   . GLN A 1 377 ? 134.687 105.254 113.312 1 75.248  ? 815 GLN A O   1 
ATOM   2829 C CB  . GLN A 1 377 ? 135.399 102.166 113.618 1 68.545  ? 815 GLN A CB  1 
ATOM   2830 C CG  . GLN A 1 377 ? 134.597 101.128 114.378 1 73.586  ? 815 GLN A CG  1 
ATOM   2831 C CD  . GLN A 1 377 ? 135.4   100.396 115.411 1 71.851  ? 815 GLN A CD  1 
ATOM   2832 O OE1 . GLN A 1 377 ? 136.336 100.944 116.004 1 86.919  ? 815 GLN A OE1 1 
ATOM   2833 N NE2 . GLN A 1 377 ? 134.98  99.176  115.666 1 69.133  ? 815 GLN A NE2 1 
ATOM   2834 N N   . ALA A 1 378 ? 135.901 104.64  111.521 1 64.048  ? 816 ALA A N   1 
ATOM   2835 C CA  . ALA A 1 378 ? 136.428 105.982 111.302 1 63.972  ? 816 ALA A CA  1 
ATOM   2836 C C   . ALA A 1 378 ? 135.303 106.944 110.939 1 66.85   ? 816 ALA A C   1 
ATOM   2837 O O   . ALA A 1 378 ? 135.255 108.077 111.408 1 73.866  ? 816 ALA A O   1 
ATOM   2838 C CB  . ALA A 1 378 ? 137.483 105.962 110.209 1 60.888  ? 816 ALA A CB  1 
ATOM   2839 N N   . CYS A 1 379 ? 134.412 106.495 110.052 1 70.279  ? 817 CYS A N   1 
ATOM   2840 C CA  . CYS A 1 379 ? 133.295 107.317 109.635 1 70.993  ? 817 CYS A CA  1 
ATOM   2841 C C   . CYS A 1 379 ? 132.345 107.545 110.806 1 69.711  ? 817 CYS A C   1 
ATOM   2842 O O   . CYS A 1 379 ? 131.819 108.638 110.968 1 63.98   ? 817 CYS A O   1 
ATOM   2843 C CB  . CYS A 1 379 ? 132.587 106.664 108.456 1 78.707  ? 817 CYS A CB  1 
ATOM   2844 S SG  . CYS A 1 379 ? 133.482 106.873 106.889 1 80.363  ? 817 CYS A SG  1 
ATOM   2845 N N   . LEU A 1 380 ? 132.117 106.511 111.624 1 64.807  ? 818 LEU A N   1 
ATOM   2846 C CA  . LEU A 1 380 ? 131.349 106.711 112.844 1 66.47   ? 818 LEU A CA  1 
ATOM   2847 C C   . LEU A 1 380 ? 132.033 107.705 113.781 1 69.558  ? 818 LEU A C   1 
ATOM   2848 O O   . LEU A 1 380 ? 131.377 108.547 114.376 1 71.735  ? 818 LEU A O   1 
ATOM   2849 C CB  . LEU A 1 380 ? 131.102 105.391 113.547 1 66.153  ? 818 LEU A CB  1 
ATOM   2850 C CG  . LEU A 1 380 ? 130.18  104.405 112.835 1 73.222  ? 818 LEU A CG  1 
ATOM   2851 C CD1 . LEU A 1 380 ? 130.39  103.077 113.468 1 72.634  ? 818 LEU A CD1 1 
ATOM   2852 C CD2 . LEU A 1 380 ? 128.727 104.821 112.905 1 75.243  ? 818 LEU A CD2 1 
ATOM   2853 N N   . GLN A 1 381 ? 133.351 107.641 113.897 1 75.334  ? 819 GLN A N   1 
ATOM   2854 C CA  . GLN A 1 381 ? 134.096 108.508 114.809 1 72.1    ? 819 GLN A CA  1 
ATOM   2855 C C   . GLN A 1 381 ? 134.072 109.969 114.379 1 65.218  ? 819 GLN A C   1 
ATOM   2856 O O   . GLN A 1 381 ? 133.932 110.849 115.223 1 77.263  ? 819 GLN A O   1 
ATOM   2857 C CB  . GLN A 1 381 ? 135.553 108.079 114.934 1 76.412  ? 819 GLN A CB  1 
ATOM   2858 C CG  . GLN A 1 381 ? 135.825 107.282 116.202 1 85.726  ? 819 GLN A CG  1 
ATOM   2859 C CD  . GLN A 1 381 ? 136.941 106.275 116.051 1 91.83   ? 819 GLN A CD  1 
ATOM   2860 O OE1 . GLN A 1 381 ? 137.829 106.406 115.21  1 82.899  ? 819 GLN A OE1 1 
ATOM   2861 N NE2 . GLN A 1 381 ? 136.903 105.24  116.876 1 118.525 ? 819 GLN A NE2 1 
ATOM   2862 N N   . MET A 1 382 ? 134.128 110.248 113.078 1 71.361  ? 820 MET A N   1 
ATOM   2863 C CA  . MET A 1 382 ? 134.08  111.637 112.646 1 78.457  ? 820 MET A CA  1 
ATOM   2864 C C   . MET A 1 382 ? 132.725 112.278 112.934 1 78.49   ? 820 MET A C   1 
ATOM   2865 O O   . MET A 1 382 ? 132.613 113.504 112.906 1 75.269  ? 820 MET A O   1 
ATOM   2866 C CB  . MET A 1 382 ? 134.442 111.811 111.17  1 83.952  ? 820 MET A CB  1 
ATOM   2867 C CG  . MET A 1 382 ? 133.522 111.186 110.186 1 97.722  ? 820 MET A CG  1 
ATOM   2868 S SD  . MET A 1 382 ? 134.226 111.202 108.51  1 94.016  ? 820 MET A SD  1 
ATOM   2869 C CE  . MET A 1 382 ? 133.59  112.75  107.88  1 87.464  ? 820 MET A CE  1 
ATOM   2870 N N   . LEU A 1 383 ? 131.703 111.453 113.195 1 70.365  ? 821 LEU A N   1 
ATOM   2871 C CA  . LEU A 1 383 ? 130.408 111.945 113.629 1 73.363  ? 821 LEU A CA  1 
ATOM   2872 C C   . LEU A 1 383 ? 130.32  112.069 115.15  1 80.099  ? 821 LEU A C   1 
ATOM   2873 O O   . LEU A 1 383 ? 129.437 112.763 115.631 1 86.128  ? 821 LEU A O   1 
ATOM   2874 C CB  . LEU A 1 383 ? 129.308 111.023 113.114 1 75.322  ? 821 LEU A CB  1 
ATOM   2875 C CG  . LEU A 1 383 ? 129.024 111.111 111.615 1 74.315  ? 821 LEU A CG  1 
ATOM   2876 C CD1 . LEU A 1 383 ? 128.066 110.041 111.173 1 74.168  ? 821 LEU A CD1 1 
ATOM   2877 C CD2 . LEU A 1 383 ? 128.489 112.467 111.211 1 73.833  ? 821 LEU A CD2 1 
ATOM   2878 N N   . GLY A 1 384 ? 131.194 111.384 115.897 1 70.929  ? 822 GLY A N   1 
ATOM   2879 C CA  . GLY A 1 384 ? 131.173 111.452 117.342 1 64.134  ? 822 GLY A CA  1 
ATOM   2880 C C   . GLY A 1 384 ? 130.244 110.405 117.981 1 66.907  ? 822 GLY A C   1 
ATOM   2881 O O   . GLY A 1 384 ? 129.859 110.557 119.132 1 79.256  ? 822 GLY A O   1 
ATOM   2882 N N   . VAL A 1 385 ? 129.894 109.337 117.267 1 63.996  ? 823 VAL A N   1 
ATOM   2883 C CA  . VAL A 1 385 ? 128.891 108.405 117.752 1 68.025  ? 823 VAL A CA  1 
ATOM   2884 C C   . VAL A 1 385 ? 129.42  106.983 117.711 1 62.182  ? 823 VAL A C   1 
ATOM   2885 O O   . VAL A 1 385 ? 128.65  106.054 117.829 1 73.787  ? 823 VAL A O   1 
ATOM   2886 C CB  . VAL A 1 385 ? 127.599 108.509 116.909 1 66.575  ? 823 VAL A CB  1 
ATOM   2887 C CG1 . VAL A 1 385 ? 127.103 109.94  116.806 1 70.354  ? 823 VAL A CG1 1 
ATOM   2888 C CG2 . VAL A 1 385 ? 127.801 107.962 115.495 1 67.442  ? 823 VAL A CG2 1 
ATOM   2889 N N   . GLN A 1 386 ? 130.72  106.788 117.588 1 69.754  ? 824 GLN A N   1 
ATOM   2890 C CA  . GLN A 1 386 ? 131.264 105.448 117.461 1 68.927  ? 824 GLN A CA  1 
ATOM   2891 C C   . GLN A 1 386 ? 131.092 104.652 118.753 1 68.213  ? 824 GLN A C   1 
ATOM   2892 O O   . GLN A 1 386 ? 131.35  105.127 119.842 1 76.166  ? 824 GLN A O   1 
ATOM   2893 C CB  . GLN A 1 386 ? 132.728 105.534 117.054 1 70.374  ? 824 GLN A CB  1 
ATOM   2894 C CG  . GLN A 1 386 ? 133.345 104.205 116.662 1 72.987  ? 824 GLN A CG  1 
ATOM   2895 C CD  . GLN A 1 386 ? 133.825 103.409 117.856 1 72.077  ? 824 GLN A CD  1 
ATOM   2896 O OE1 . GLN A 1 386 ? 134.437 103.953 118.78  1 85.742  ? 824 GLN A OE1 1 
ATOM   2897 N NE2 . GLN A 1 386 ? 133.555 102.119 117.858 1 70.65   ? 824 GLN A NE2 1 
ATOM   2898 N N   . GLY A 1 387 ? 130.685 103.4   118.603 1 69.09   ? 825 GLY A N   1 
ATOM   2899 C CA  . GLY A 1 387 ? 130.636 102.451 119.693 1 68.165  ? 825 GLY A CA  1 
ATOM   2900 C C   . GLY A 1 387 ? 129.5   102.726 120.684 1 76.731  ? 825 GLY A C   1 
ATOM   2901 O O   . GLY A 1 387 ? 128.623 103.56  120.444 1 76.766  ? 825 GLY A O   1 
ATOM   2902 N N   . ALA A 1 388 ? 129.55  102.012 121.817 1 72.143  ? 826 ALA A N   1 
ATOM   2903 C CA  . ALA A 1 388 ? 128.565 102.136 122.883 1 79.229  ? 826 ALA A CA  1 
ATOM   2904 C C   . ALA A 1 388 ? 128.813 103.39  123.711 1 80.426  ? 826 ALA A C   1 
ATOM   2905 O O   . ALA A 1 388 ? 129.951 103.777 123.95  1 96.877  ? 826 ALA A O   1 
ATOM   2906 C CB  . ALA A 1 388 ? 128.596 100.927 123.77  1 74.469  ? 826 ALA A CB  1 
ATOM   2907 N N   . CYS A 1 389 ? 127.719 104.03  124.12  1 86.88   ? 827 CYS A N   1 
ATOM   2908 C CA  . CYS A 1 389 ? 127.764 105.181 125.007 1 89.974  ? 827 CYS A CA  1 
ATOM   2909 C C   . CYS A 1 389 ? 127.503 104.712 126.436 1 82.519  ? 827 CYS A C   1 
ATOM   2910 O O   . CYS A 1 389 ? 126.365 104.441 126.79  1 94.918  ? 827 CYS A O   1 
ATOM   2911 C CB  . CYS A 1 389 ? 126.735 106.208 124.557 1 85.925  ? 827 CYS A CB  1 
ATOM   2912 S SG  . CYS A 1 389 ? 126.42  107.489 125.793 1 102.626 ? 827 CYS A SG  1 
ATOM   2913 N N   . LYS A 1 390 ? 128.555 104.585 127.247 1 100.124 ? 828 LYS A N   1 
ATOM   2914 C CA  . LYS A 1 390 ? 128.453 103.878 128.519 1 102.539 ? 828 LYS A CA  1 
ATOM   2915 C C   . LYS A 1 390 ? 127.485 104.581 129.474 1 95.995  ? 828 LYS A C   1 
ATOM   2916 O O   . LYS A 1 390 ? 126.733 103.918 130.19  1 101.456 ? 828 LYS A O   1 
ATOM   2917 C CB  . LYS A 1 390 ? 129.83  103.749 129.174 1 107.062 ? 828 LYS A CB  1 
ATOM   2918 C CG  . LYS A 1 390 ? 129.844 102.777 130.354 1 118.165 ? 828 LYS A CG  1 
ATOM   2919 C CD  . LYS A 1 390 ? 131.235 102.333 130.8   1 128.718 ? 828 LYS A CD  1 
ATOM   2920 C CE  . LYS A 1 390 ? 132.077 101.798 129.667 1 133.968 ? 828 LYS A CE  1 
ATOM   2921 N NZ  . LYS A 1 390 ? 131.312 100.904 128.786 1 136.889 ? 828 LYS A NZ  1 
ATOM   2922 N N   . ASP A 1 391 ? 127.502 105.919 129.485 1 88.452  ? 829 ASP A N   1 
ATOM   2923 C CA  . ASP A 1 391 ? 126.664 106.664 130.413 1 98.657  ? 829 ASP A CA  1 
ATOM   2924 C C   . ASP A 1 391 ? 125.185 106.431 130.121 1 103.214 ? 829 ASP A C   1 
ATOM   2925 O O   . ASP A 1 391 ? 124.419 106.077 131.016 1 117.361 ? 829 ASP A O   1 
ATOM   2926 C CB  . ASP A 1 391 ? 126.951 108.153 130.352 1 112.537 ? 829 ASP A CB  1 
ATOM   2927 C CG  . ASP A 1 391 ? 128.218 108.575 131.076 1 131.544 ? 829 ASP A CG  1 
ATOM   2928 O OD1 . ASP A 1 391 ? 128.775 107.727 131.819 1 124.477 ? 829 ASP A OD1 1 
ATOM   2929 O OD2 . ASP A 1 391 ? 128.635 109.745 130.887 1 133.349 ? 829 ASP A OD2 1 
ATOM   2930 N N   . ASN A 1 392 ? 124.792 106.635 128.857 1 102.124 ? 830 ASN A N   1 
ATOM   2931 C CA  . ASN A 1 392 ? 123.389 106.69  128.474 1 88.257  ? 830 ASN A CA  1 
ATOM   2932 C C   . ASN A 1 392 ? 123.134 105.721 127.322 1 88.164  ? 830 ASN A C   1 
ATOM   2933 O O   . ASN A 1 392 ? 123.063 106.128 126.163 1 81.996  ? 830 ASN A O   1 
ATOM   2934 C CB  . ASN A 1 392 ? 123.029 108.116 128.084 1 84.492  ? 830 ASN A CB  1 
ATOM   2935 C CG  . ASN A 1 392 ? 121.575 108.267 127.714 1 93.962  ? 830 ASN A CG  1 
ATOM   2936 O OD1 . ASN A 1 392 ? 120.768 107.344 127.903 1 94.495  ? 830 ASN A OD1 1 
ATOM   2937 N ND2 . ASN A 1 392 ? 121.225 109.431 127.189 1 100.45  ? 830 ASN A ND2 1 
ATOM   2938 N N   . PRO A 1 393 ? 122.985 104.407 127.589 1 87.729  ? 831 PRO A N   1 
ATOM   2939 C CA  . PRO A 1 393 ? 122.948 103.418 126.52  1 78.455  ? 831 PRO A CA  1 
ATOM   2940 C C   . PRO A 1 393 ? 121.935 103.728 125.431 1 86.499  ? 831 PRO A C   1 
ATOM   2941 O O   . PRO A 1 393 ? 120.812 104.144 125.715 1 79.826  ? 831 PRO A O   1 
ATOM   2942 C CB  . PRO A 1 393 ? 122.571 102.132 127.243 1 88.636  ? 831 PRO A CB  1 
ATOM   2943 C CG  . PRO A 1 393 ? 123.168 102.361 128.627 1 80.972  ? 831 PRO A CG  1 
ATOM   2944 C CD  . PRO A 1 393 ? 122.835 103.792 128.918 1 86.361  ? 831 PRO A CD  1 
ATOM   2945 N N   . GLY A 1 394 ? 122.368 103.563 124.181 1 84.016  ? 832 GLY A N   1 
ATOM   2946 C CA  . GLY A 1 394 ? 121.533 103.861 123.038 1 74.33   ? 832 GLY A CA  1 
ATOM   2947 C C   . GLY A 1 394 ? 121.646 105.305 122.566 1 68.237  ? 832 GLY A C   1 
ATOM   2948 O O   . GLY A 1 394 ? 121.115 105.629 121.512 1 75.965  ? 832 GLY A O   1 
ATOM   2949 N N   . GLU A 1 395 ? 122.337 106.17  123.303 1 74.495  ? 833 GLU A N   1 
ATOM   2950 C CA  . GLU A 1 395 ? 122.398 107.575 122.92  1 70.429  ? 833 GLU A CA  1 
ATOM   2951 C C   . GLU A 1 395 ? 123.13  107.788 121.587 1 75.673  ? 833 GLU A C   1 
ATOM   2952 O O   . GLU A 1 395 ? 122.75  108.632 120.781 1 70.268  ? 833 GLU A O   1 
ATOM   2953 C CB  . GLU A 1 395 ? 123.063 108.385 124.018 1 73.243  ? 833 GLU A CB  1 
ATOM   2954 C CG  . GLU A 1 395 ? 123.135 109.874 123.703 1 89.179  ? 833 GLU A CG  1 
ATOM   2955 C CD  . GLU A 1 395 ? 121.807 110.466 123.242 1 103.858 ? 833 GLU A CD  1 
ATOM   2956 O OE1 . GLU A 1 395 ? 120.757 110.044 123.775 1 106.309 ? 833 GLU A OE1 1 
ATOM   2957 O OE2 . GLU A 1 395 ? 121.814 111.343 122.349 1 118.396 ? 833 GLU A OE2 1 
ATOM   2958 N N   . ASN A 1 396 ? 124.181 107.018 121.332 1 71.053  ? 834 ASN A N   1 
ATOM   2959 C CA  . ASN A 1 396 ? 124.932 107.155 120.094 1 69.587  ? 834 ASN A CA  1 
ATOM   2960 C C   . ASN A 1 396 ? 124.108 106.72  118.884 1 68.678  ? 834 ASN A C   1 
ATOM   2961 O O   . ASN A 1 396 ? 124.106 107.393 117.854 1 64.458  ? 834 ASN A O   1 
ATOM   2962 C CB  . ASN A 1 396 ? 126.215 106.339 120.151 1 73.234  ? 834 ASN A CB  1 
ATOM   2963 C CG  . ASN A 1 396 ? 127.322 107.027 120.91  1 67.066  ? 834 ASN A CG  1 
ATOM   2964 O OD1 . ASN A 1 396 ? 127.228 108.21  121.242 1 73.499  ? 834 ASN A OD1 1 
ATOM   2965 N ND2 . ASN A 1 396 ? 128.374 106.288 121.201 1 67.732  ? 834 ASN A ND2 1 
ATOM   2966 N N   . ALA A 1 397 ? 123.352 105.632 119.02  1 59.935  ? 835 ALA A N   1 
ATOM   2967 C CA  . ALA A 1 397 ? 122.484 105.194 117.938 1 62.413  ? 835 ALA A CA  1 
ATOM   2968 C C   . ALA A 1 397 ? 121.406 106.243 117.657 1 70.956  ? 835 ALA A C   1 
ATOM   2969 O O   . ALA A 1 397 ? 121.115 106.53  116.488 1 67.952  ? 835 ALA A O   1 
ATOM   2970 C CB  . ALA A 1 397 ? 121.883 103.863 118.248 1 68.581  ? 835 ALA A CB  1 
ATOM   2971 N N   . ARG A 1 398 ? 120.849 106.841 118.719 1 63.591  ? 836 ARG A N   1 
ATOM   2972 C CA  . ARG A 1 398 ? 119.839 107.869 118.551 1 68.425  ? 836 ARG A CA  1 
ATOM   2973 C C   . ARG A 1 398 ? 120.417 109.083 117.84  1 67.76   ? 836 ARG A C   1 
ATOM   2974 O O   . ARG A 1 398 ? 119.775 109.672 116.958 1 70.644  ? 836 ARG A O   1 
ATOM   2975 C CB  . ARG A 1 398 ? 119.229 108.291 119.891 1 70.978  ? 836 ARG A CB  1 
ATOM   2976 C CG  . ARG A 1 398 ? 118.255 107.245 120.418 1 75.693  ? 836 ARG A CG  1 
ATOM   2977 C CD  . ARG A 1 398 ? 117.61  107.689 121.727 1 79.031  ? 836 ARG A CD  1 
ATOM   2978 N NE  . ARG A 1 398 ? 118.084 106.829 122.813 1 83.945  ? 836 ARG A NE  1 
ATOM   2979 C CZ  . ARG A 1 398 ? 118.738 107.219 123.895 1 102.981 ? 836 ARG A CZ  1 
ATOM   2980 N NH1 . ARG A 1 398 ? 119.052 108.496 124.107 1 101.049 ? 836 ARG A NH1 1 
ATOM   2981 N NH2 . ARG A 1 398 ? 119.08  106.304 124.781 1 92.428  ? 836 ARG A NH2 1 
ATOM   2982 N N   . GLN A 1 399 ? 121.636 109.463 118.221 1 61.912  ? 837 GLN A N   1 
ATOM   2983 C CA  . GLN A 1 399 ? 122.267 110.61  117.592 1 60.124  ? 837 GLN A CA  1 
ATOM   2984 C C   . GLN A 1 399 ? 122.509 110.326 116.105 1 59.129  ? 837 GLN A C   1 
ATOM   2985 O O   . GLN A 1 399 ? 122.318 111.197 115.259 1 59.338  ? 837 GLN A O   1 
ATOM   2986 C CB  . GLN A 1 399 ? 123.569 110.94  118.316 1 61.568  ? 837 GLN A CB  1 
ATOM   2987 C CG  . GLN A 1 399 ? 124.342 112.079 117.685 1 64.934  ? 837 GLN A CG  1 
ATOM   2988 C CD  . GLN A 1 399 ? 123.576 113.367 117.761 1 75.163  ? 837 GLN A CD  1 
ATOM   2989 O OE1 . GLN A 1 399 ? 123.654 114.097 118.754 1 93.348  ? 837 GLN A OE1 1 
ATOM   2990 N NE2 . GLN A 1 399 ? 122.855 113.674 116.69  1 86.827  ? 837 GLN A NE2 1 
ATOM   2991 N N   . LEU A 1 400 ? 122.963 109.121 115.793 1 55.871  ? 838 LEU A N   1 
ATOM   2992 C CA  . LEU A 1 400 ? 123.186 108.759 114.407 1 62.236  ? 838 LEU A CA  1 
ATOM   2993 C C   . LEU A 1 400 ? 121.872 108.804 113.613 1 62.212  ? 838 LEU A C   1 
ATOM   2994 O O   . LEU A 1 400 ? 121.844 109.243 112.463 1 65.012  ? 838 LEU A O   1 
ATOM   2995 C CB  . LEU A 1 400 ? 123.837 107.375 114.317 1 60.169  ? 838 LEU A CB  1 
ATOM   2996 C CG  . LEU A 1 400 ? 124.174 106.938 112.888 1 66.736  ? 838 LEU A CG  1 
ATOM   2997 C CD1 . LEU A 1 400 ? 125.004 107.982 112.165 1 65.988  ? 838 LEU A CD1 1 
ATOM   2998 C CD2 . LEU A 1 400 ? 124.882 105.609 112.856 1 61.518  ? 838 LEU A CD2 1 
ATOM   2999 N N   . ALA A 1 401 ? 120.77  108.361 114.221 1 65.514  ? 839 ALA A N   1 
ATOM   3000 C CA  . ALA A 1 401 ? 119.471 108.434 113.56  1 67.498  ? 839 ALA A CA  1 
ATOM   3001 C C   . ALA A 1 401 ? 119.063 109.874 113.282 1 59.028  ? 839 ALA A C   1 
ATOM   3002 O O   . ALA A 1 401 ? 118.585 110.182 112.19  1 64.738  ? 839 ALA A O   1 
ATOM   3003 C CB  . ALA A 1 401 ? 118.42  107.718 114.359 1 66.8    ? 839 ALA A CB  1 
ATOM   3004 N N   . ARG A 1 402 ? 119.306 110.755 114.245 1 61.153  ? 840 ARG A N   1 
ATOM   3005 C CA  . ARG A 1 402 ? 119.012 112.166 114.065 1 62.074  ? 840 ARG A CA  1 
ATOM   3006 C C   . ARG A 1 402 ? 119.828 112.739 112.909 1 68.461  ? 840 ARG A C   1 
ATOM   3007 O O   . ARG A 1 402 ? 119.312 113.513 112.105 1 66.114  ? 840 ARG A O   1 
ATOM   3008 C CB  . ARG A 1 402 ? 119.25  112.945 115.361 1 64.039  ? 840 ARG A CB  1 
ATOM   3009 C CG  . ARG A 1 402 ? 118.243 112.594 116.449 1 69.659  ? 840 ARG A CG  1 
ATOM   3010 C CD  . ARG A 1 402 ? 118.654 113.004 117.843 1 75.58   ? 840 ARG A CD  1 
ATOM   3011 N NE  . ARG A 1 402 ? 118.497 114.43  118.068 1 76.717  ? 840 ARG A NE  1 
ATOM   3012 C CZ  . ARG A 1 402 ? 117.825 114.989 119.076 1 101.066 ? 840 ARG A CZ  1 
ATOM   3013 N NH1 . ARG A 1 402 ? 117.126 114.25  119.929 1 123.337 ? 840 ARG A NH1 1 
ATOM   3014 N NH2 . ARG A 1 402 ? 117.793 116.307 119.204 1 93.521  ? 840 ARG A NH2 1 
ATOM   3015 N N   . ILE A 1 403 ? 121.109 112.382 112.832 1 67.512  ? 841 ILE A N   1 
ATOM   3016 C CA  . ILE A 1 403 ? 121.975 112.902 111.78  1 67.52   ? 841 ILE A CA  1 
ATOM   3017 C C   . ILE A 1 403 ? 121.477 112.385 110.427 1 63.676  ? 841 ILE A C   1 
ATOM   3018 O O   . ILE A 1 403 ? 121.477 113.098 109.441 1 54.793  ? 841 ILE A O   1 
ATOM   3019 C CB  . ILE A 1 403 ? 123.439 112.493 112.037 1 73.53   ? 841 ILE A CB  1 
ATOM   3020 C CG1 . ILE A 1 403 ? 124.054 113.315 113.184 1 69.305  ? 841 ILE A CG1 1 
ATOM   3021 C CG2 . ILE A 1 403 ? 124.29  112.623 110.774 1 67.663  ? 841 ILE A CG2 1 
ATOM   3022 C CD1 . ILE A 1 403 ? 125.23  112.612 113.846 1 64.759  ? 841 ILE A CD1 1 
ATOM   3023 N N   . VAL A 1 404 ? 121.063 111.123 110.38  1 59.023  ? 842 VAL A N   1 
ATOM   3024 C CA  . VAL A 1 404 ? 120.55  110.572 109.147 1 64.857  ? 842 VAL A CA  1 
ATOM   3025 C C   . VAL A 1 404 ? 119.334 111.363 108.67  1 68.088  ? 842 VAL A C   1 
ATOM   3026 O O   . VAL A 1 404 ? 119.252 111.762 107.505 1 63.374  ? 842 VAL A O   1 
ATOM   3027 C CB  . VAL A 1 404 ? 120.243 109.082 109.282 1 63.342  ? 842 VAL A CB  1 
ATOM   3028 C CG1 . VAL A 1 404 ? 119.325 108.628 108.169 1 66.319  ? 842 VAL A CG1 1 
ATOM   3029 C CG2 . VAL A 1 404 ? 121.535 108.26  109.299 1 66.642  ? 842 VAL A CG2 1 
ATOM   3030 N N   . CYS A 1 405 ? 118.399 111.63  109.58  1 69.358  ? 843 CYS A N   1 
ATOM   3031 C CA  . CYS A 1 405 ? 117.207 112.372 109.223 1 64.572  ? 843 CYS A CA  1 
ATOM   3032 C C   . CYS A 1 405 ? 117.558 113.777 108.747 1 56.964  ? 843 CYS A C   1 
ATOM   3033 O O   . CYS A 1 405 ? 116.987 114.273 107.772 1 60.35   ? 843 CYS A O   1 
ATOM   3034 C CB  . CYS A 1 405 ? 116.209 112.387 110.373 1 78.655  ? 843 CYS A CB  1 
ATOM   3035 S SG  . CYS A 1 405 ? 114.519 112.87  109.885 1 73.884  ? 843 CYS A SG  1 
ATOM   3036 N N   . GLY A 1 406 ? 118.473 114.45  109.445 1 59.982  ? 844 GLY A N   1 
ATOM   3037 C CA  . GLY A 1 406 ? 118.865 115.796 109.065 1 58.63   ? 844 GLY A CA  1 
ATOM   3038 C C   . GLY A 1 406 ? 119.538 115.856 107.688 1 60.232  ? 844 GLY A C   1 
ATOM   3039 O O   . GLY A 1 406 ? 119.274 116.747 106.891 1 65.623  ? 844 GLY A O   1 
ATOM   3040 N N   . THR A 1 407 ? 120.404 114.892 107.405 1 59.944  ? 845 THR A N   1 
ATOM   3041 C CA  . THR A 1 407 ? 121.068 114.837 106.114 1 63.633  ? 845 THR A CA  1 
ATOM   3042 C C   . THR A 1 407 ? 120.037 114.556 105.018 1 63.767  ? 845 THR A C   1 
ATOM   3043 O O   . THR A 1 407 ? 120.126 115.115 103.931 1 54.737  ? 845 THR A O   1 
ATOM   3044 C CB  . THR A 1 407 ? 122.145 113.744 106.115 1 66.715  ? 845 THR A CB  1 
ATOM   3045 O OG1 . THR A 1 407 ? 122.92  113.878 107.305 1 59.948  ? 845 THR A OG1 1 
ATOM   3046 C CG2 . THR A 1 407 ? 123.07  113.864 104.92  1 69.811  ? 845 THR A CG2 1 
ATOM   3047 N N   . VAL A 1 408 ? 119.093 113.634 105.277 1 61.616  ? 846 VAL A N   1 
ATOM   3048 C CA  . VAL A 1 408 ? 118.033 113.371 104.32  1 58.952  ? 846 VAL A CA  1 
ATOM   3049 C C   . VAL A 1 408 ? 117.302 114.684 104.024 1 59.651  ? 846 VAL A C   1 
ATOM   3050 O O   . VAL A 1 408 ? 116.975 114.999 102.881 1 61.679  ? 846 VAL A O   1 
ATOM   3051 C CB  . VAL A 1 408 ? 117.067 112.278 104.817 1 58.932  ? 846 VAL A CB  1 
ATOM   3052 C CG1 . VAL A 1 408 ? 115.714 112.38  104.149 1 56.649  ? 846 VAL A CG1 1 
ATOM   3053 C CG2 . VAL A 1 408 ? 117.645 110.893 104.648 1 62.268  ? 846 VAL A CG2 1 
ATOM   3054 N N   . MET A 1 409 ? 117.013 115.456 105.061 1 59.837  ? 847 MET A N   1 
ATOM   3055 C CA  . MET A 1 409 ? 116.306 116.707 104.862 1 61.949  ? 847 MET A CA  1 
ATOM   3056 C C   . MET A 1 409 ? 117.099 117.679 103.989 1 67.374  ? 847 MET A C   1 
ATOM   3057 O O   . MET A 1 409 ? 116.526 118.329 103.113 1 65.508  ? 847 MET A O   1 
ATOM   3058 C CB  . MET A 1 409 ? 115.992 117.336 106.216 1 64.391  ? 847 MET A CB  1 
ATOM   3059 C CG  . MET A 1 409 ? 114.864 118.311 106.203 1 69.261  ? 847 MET A CG  1 
ATOM   3060 S SD  . MET A 1 409 ? 114.46  118.971 107.831 1 81.155  ? 847 MET A SD  1 
ATOM   3061 C CE  . MET A 1 409 ? 115.756 120.193 107.949 1 77.945  ? 847 MET A CE  1 
ATOM   3062 N N   . ALA A 1 410 ? 118.41  117.804 104.217 1 63.449  ? 848 ALA A N   1 
ATOM   3063 C CA  . ALA A 1 410 ? 119.246 118.664 103.376 1 66.813  ? 848 ALA A CA  1 
ATOM   3064 C C   . ALA A 1 410 ? 119.216 118.202 101.909 1 66.419  ? 848 ALA A C   1 
ATOM   3065 O O   . ALA A 1 410 ? 119.095 119.005 100.999 1 71.536  ? 848 ALA A O   1 
ATOM   3066 C CB  . ALA A 1 410 ? 120.671 118.65  103.911 1 64.797  ? 848 ALA A CB  1 
ATOM   3067 N N   . GLY A 1 411 ? 119.319 116.895 101.686 1 61.162  ? 849 GLY A N   1 
ATOM   3068 C CA  . GLY A 1 411 ? 119.232 116.339 100.352 1 68.124  ? 849 GLY A CA  1 
ATOM   3069 C C   . GLY A 1 411 ? 117.894 116.645 99.674  1 62.304  ? 849 GLY A C   1 
ATOM   3070 O O   . GLY A 1 411 ? 117.855 117.006 98.505  1 71.459  ? 849 GLY A O   1 
ATOM   3071 N N   . GLU A 1 412 ? 116.797 116.513 100.427 1 68.234  ? 850 GLU A N   1 
ATOM   3072 C CA  . GLU A 1 412 ? 115.48  116.828 99.912  1 66.44   ? 850 GLU A CA  1 
ATOM   3073 C C   . GLU A 1 412 ? 115.451 118.294 99.487  1 63.466  ? 850 GLU A C   1 
ATOM   3074 O O   . GLU A 1 412 ? 114.984 118.624 98.407  1 61.517  ? 850 GLU A O   1 
ATOM   3075 C CB  . GLU A 1 412 ? 114.374 116.546 100.924 1 67.77   ? 850 GLU A CB  1 
ATOM   3076 C CG  . GLU A 1 412 ? 114.198 115.063 101.236 1 73.561  ? 850 GLU A CG  1 
ATOM   3077 C CD  . GLU A 1 412 ? 113.607 114.285 100.077 1 80.717  ? 850 GLU A CD  1 
ATOM   3078 O OE1 . GLU A 1 412 ? 112.419 114.547 99.735  1 94.403  ? 850 GLU A OE1 1 
ATOM   3079 O OE2 . GLU A 1 412 ? 114.325 113.42  99.508  1 88.738  ? 850 GLU A OE2 1 
ATOM   3080 N N   . LEU A 1 413 ? 115.936 119.169 100.357 1 62.478  ? 851 LEU A N   1 
ATOM   3081 C CA  . LEU A 1 413 ? 115.909 120.589 100.08  1 66.383  ? 851 LEU A CA  1 
ATOM   3082 C C   . LEU A 1 413 ? 116.61  120.865 98.753  1 71.752  ? 851 LEU A C   1 
ATOM   3083 O O   . LEU A 1 413 ? 116.062 121.525 97.874  1 71.333  ? 851 LEU A O   1 
ATOM   3084 C CB  . LEU A 1 413 ? 116.574 121.319 101.243 1 66.356  ? 851 LEU A CB  1 
ATOM   3085 C CG  . LEU A 1 413 ? 116.382 122.831 101.307 1 77.735  ? 851 LEU A CG  1 
ATOM   3086 C CD1 . LEU A 1 413 ? 114.91  123.21  101.227 1 69.265  ? 851 LEU A CD1 1 
ATOM   3087 C CD2 . LEU A 1 413 ? 117.039 123.335 102.599 1 77.514  ? 851 LEU A CD2 1 
ATOM   3088 N N   . SER A 1 414 ? 117.813 120.317 98.588  1 66.866  ? 852 SER A N   1 
ATOM   3089 C CA  . SER A 1 414 ? 118.61  120.612 97.413  1 69.671  ? 852 SER A CA  1 
ATOM   3090 C C   . SER A 1 414 ? 117.958 120.056 96.14   1 63.906  ? 852 SER A C   1 
ATOM   3091 O O   . SER A 1 414 ? 117.825 120.769 95.153  1 63.263  ? 852 SER A O   1 
ATOM   3092 C CB  . SER A 1 414 ? 119.999 120.092 97.596  1 66.265  ? 852 SER A CB  1 
ATOM   3093 O OG  . SER A 1 414 ? 120.854 120.533 96.558  1 61.142  ? 852 SER A OG  1 
ATOM   3094 N N   . LEU A 1 415 ? 117.571 118.785 96.15   1 56.57   ? 853 LEU A N   1 
ATOM   3095 C CA  . LEU A 1 415 ? 117.028 118.17  94.949  1 60.151  ? 853 LEU A CA  1 
ATOM   3096 C C   . LEU A 1 415 ? 115.704 118.83  94.562  1 67.086  ? 853 LEU A C   1 
ATOM   3097 O O   . LEU A 1 415 ? 115.43  119.037 93.377  1 63.037  ? 853 LEU A O   1 
ATOM   3098 C CB  . LEU A 1 415 ? 116.852 116.669 95.121  1 65.32   ? 853 LEU A CB  1 
ATOM   3099 C CG  . LEU A 1 415 ? 116.145 115.941 93.973  1 68.062  ? 853 LEU A CG  1 
ATOM   3100 C CD1 . LEU A 1 415 ? 116.894 116.188 92.637  1 67.435  ? 853 LEU A CD1 1 
ATOM   3101 C CD2 . LEU A 1 415 ? 116.013 114.428 94.26   1 67.879  ? 853 LEU A CD2 1 
ATOM   3102 N N   . MET A 1 416 ? 114.884 119.167 95.561  1 67.338  ? 854 MET A N   1 
ATOM   3103 C CA  . MET A 1 416 ? 113.612 119.809 95.293  1 66.419  ? 854 MET A CA  1 
ATOM   3104 C C   . MET A 1 416 ? 113.839 121.177 94.661  1 67.151  ? 854 MET A C   1 
ATOM   3105 O O   . MET A 1 416 ? 113.113 121.554 93.745  1 62.241  ? 854 MET A O   1 
ATOM   3106 C CB  . MET A 1 416 ? 112.752 119.908 96.554  1 66.629  ? 854 MET A CB  1 
ATOM   3107 C CG  . MET A 1 416 ? 112.265 118.542 97.052  1 80.902  ? 854 MET A CG  1 
ATOM   3108 S SD  . MET A 1 416 ? 111.214 117.673 95.869  1 76.607  ? 854 MET A SD  1 
ATOM   3109 C CE  . MET A 1 416 ? 109.789 118.754 96.112  1 82.442  ? 854 MET A CE  1 
ATOM   3110 N N   . ALA A 1 417 ? 114.816 121.928 95.169  1 64.068  ? 855 ALA A N   1 
ATOM   3111 C CA  . ALA A 1 417 ? 115.147 123.213 94.581  1 62.965  ? 855 ALA A CA  1 
ATOM   3112 C C   . ALA A 1 417 ? 115.586 123.028 93.125  1 60.885  ? 855 ALA A C   1 
ATOM   3113 O O   . ALA A 1 417 ? 115.177 123.765 92.25   1 59.156  ? 855 ALA A O   1 
ATOM   3114 C CB  . ALA A 1 417 ? 116.202 123.908 95.393  1 62.676  ? 855 ALA A CB  1 
ATOM   3115 N N   . ALA A 1 418 ? 116.425 122.034 92.851  1 59.999  ? 856 ALA A N   1 
ATOM   3116 C CA  . ALA A 1 418 ? 116.895 121.813 91.496  1 61.168  ? 856 ALA A CA  1 
ATOM   3117 C C   . ALA A 1 418 ? 115.712 121.501 90.571  1 71.892  ? 856 ALA A C   1 
ATOM   3118 O O   . ALA A 1 418 ? 115.643 122.018 89.471  1 71.487  ? 856 ALA A O   1 
ATOM   3119 C CB  . ALA A 1 418 ? 117.906 120.674 91.481  1 63.682  ? 856 ALA A CB  1 
ATOM   3120 N N   . LEU A 1 419 ? 114.797 120.614 90.995  1 68.962  ? 857 LEU A N   1 
ATOM   3121 C CA  . LEU A 1 419 ? 113.63  120.279 90.192  1 65.353  ? 857 LEU A CA  1 
ATOM   3122 C C   . LEU A 1 419 ? 112.723 121.488 89.98   1 61.155  ? 857 LEU A C   1 
ATOM   3123 O O   . LEU A 1 419 ? 112.188 121.667 88.899  1 68.771  ? 857 LEU A O   1 
ATOM   3124 C CB  . LEU A 1 419 ? 112.838 119.148 90.833  1 66.668  ? 857 LEU A CB  1 
ATOM   3125 C CG  . LEU A 1 419 ? 113.547 117.807 90.805  1 68.197  ? 857 LEU A CG  1 
ATOM   3126 C CD1 . LEU A 1 419 ? 112.864 116.856 91.748  1 68.821  ? 857 LEU A CD1 1 
ATOM   3127 C CD2 . LEU A 1 419 ? 113.632 117.256 89.383  1 67.471  ? 857 LEU A CD2 1 
ATOM   3128 N N   . ALA A 1 420 ? 112.549 122.321 90.999  1 67.007  ? 858 ALA A N   1 
ATOM   3129 C CA  . ALA A 1 420 ? 111.665 123.464 90.885  1 67.634  ? 858 ALA A CA  1 
ATOM   3130 C C   . ALA A 1 420 ? 112.251 124.521 89.961  1 71.383  ? 858 ALA A C   1 
ATOM   3131 O O   . ALA A 1 420 ? 111.513 125.191 89.249  1 94.391  ? 858 ALA A O   1 
ATOM   3132 C CB  . ALA A 1 420 ? 111.352 124.039 92.242  1 68.242  ? 858 ALA A CB  1 
ATOM   3133 N N   . ALA A 1 421 ? 113.568 124.693 89.981  1 81.701  ? 859 ALA A N   1 
ATOM   3134 C CA  . ALA A 1 421 ? 114.222 125.728 89.191  1 77.587  ? 859 ALA A CA  1 
ATOM   3135 C C   . ALA A 1 421 ? 114.316 125.346 87.718  1 81.379  ? 859 ALA A C   1 
ATOM   3136 O O   . ALA A 1 421 ? 114.54  126.218 86.884  1 100.385 ? 859 ALA A O   1 
ATOM   3137 C CB  . ALA A 1 421 ? 115.6   125.996 89.745  1 76.349  ? 859 ALA A CB  1 
ATOM   3138 N N   . GLY A 1 422 ? 114.18  124.048 87.396  1 91.444  ? 860 GLY A N   1 
ATOM   3139 C CA  . GLY A 1 422 ? 114.459 123.551 86.056  1 97.881  ? 860 GLY A CA  1 
ATOM   3140 C C   . GLY A 1 422 ? 115.966 123.511 85.797  1 114.543 ? 860 GLY A C   1 
ATOM   3141 O O   . GLY A 1 422 ? 116.781 123.644 86.717  1 113.811 ? 860 GLY A O   1 
ATOM   3142 N N   . HIS A 1 423 ? 116.342 123.318 84.53   1 124.743 ? 861 HIS A N   1 
ATOM   3143 C CA  . HIS A 1 423 ? 117.751 123.213 84.182  1 134.532 ? 861 HIS A CA  1 
ATOM   3144 C C   . HIS A 1 423 ? 118.362 124.61  84.009  1 147.803 ? 861 HIS A C   1 
ATOM   3145 O O   . HIS A 1 423 ? 117.653 125.514 83.493  1 160.749 ? 861 HIS A O   1 
ATOM   3146 C CB  . HIS A 1 423 ? 117.955 122.334 82.942  1 143.596 ? 861 HIS A CB  1 
ATOM   3147 C CG  . HIS A 1 423 ? 118.459 120.964 83.265  1 141.537 ? 861 HIS A CG  1 
ATOM   3148 N ND1 . HIS A 1 423 ? 119.714 120.771 83.807  1 148.788 ? 861 HIS A ND1 1 
ATOM   3149 C CD2 . HIS A 1 423 ? 117.919 119.737 83.138  1 154.167 ? 861 HIS A CD2 1 
ATOM   3150 C CE1 . HIS A 1 423 ? 119.923 119.467 83.987  1 152.144 ? 861 HIS A CE1 1 
ATOM   3151 N NE2 . HIS A 1 423 ? 118.844 118.819 83.592  1 145.202 ? 861 HIS A NE2 1 
HETATM 3152 C C17 . 117 B 2 .   ? 117.252 81.441  110.154 1 69.686  ? 901 117 A C17 1 
HETATM 3153 C C12 . 117 B 2 .   ? 118.623 81.688  110.026 1 70.068  ? 901 117 A C12 1 
HETATM 3154 C C13 . 117 B 2 .   ? 119.489 80.858  110.729 1 72.663  ? 901 117 A C13 1 
HETATM 3155 C C14 . 117 B 2 .   ? 119.01  79.777  111.455 1 74.616  ? 901 117 A C14 1 
HETATM 3156 C C15 . 117 B 2 .   ? 117.656 79.537  111.536 1 73.346  ? 901 117 A C15 1 
HETATM 3157 C C16 . 117 B 2 .   ? 116.781 80.397  110.923 1 69.186  ? 901 117 A C16 1 
HETATM 3158 C C83 . 117 B 2 .   ? 117.37  85.398  112.823 1 99.731  ? 901 117 A C83 1 
HETATM 3159 C C82 . 117 B 2 .   ? 118.25  84.905  111.89  1 93.606  ? 901 117 A C82 1 
HETATM 3160 C C81 . 117 B 2 .   ? 117.874 84.772  110.556 1 79.169  ? 901 117 A C81 1 
HETATM 3161 C C86 . 117 B 2 .   ? 116.536 85.05   110.21  1 80.957  ? 901 117 A C86 1 
HETATM 3162 C C85 . 117 B 2 .   ? 115.658 85.594  111.134 1 92.919  ? 901 117 A C85 1 
HETATM 3163 C C84 . 117 B 2 .   ? 116.103 85.738  112.428 1 99.918  ? 901 117 A C84 1 
HETATM 3164 F F1  . 117 B 2 .   ? 115.294 86.293  113.361 1 94.983  ? 901 117 A F1  1 
HETATM 3165 C C8  . 117 B 2 .   ? 118.816 84.185  109.576 1 70.545  ? 901 117 A C8  1 
HETATM 3166 C C19 . 117 B 2 .   ? 122.557 80.306  107.327 1 82.276  ? 901 117 A C19 1 
HETATM 3167 C C20 . 117 B 2 .   ? 123.887 80.635  107.523 1 88.46   ? 901 117 A C20 1 
HETATM 3168 C C21 . 117 B 2 .   ? 124.874 79.807  107.002 1 87.596  ? 901 117 A C21 1 
HETATM 3169 C C22 . 117 B 2 .   ? 124.542 78.676  106.294 1 80.69   ? 901 117 A C22 1 
HETATM 3170 C C23 . 117 B 2 .   ? 123.218 78.348  106.108 1 92.251  ? 901 117 A C23 1 
HETATM 3171 C C24 . 117 B 2 .   ? 122.215 79.156  106.626 1 83.691  ? 901 117 A C24 1 
HETATM 3172 O O1B . 117 B 2 .   ? 112.963 87.029  107.446 1 63.996  ? 901 117 A O1B 1 
HETATM 3173 O O1A . 117 B 2 .   ? 112.099 89.056  107.794 1 99.596  ? 901 117 A O1A 1 
HETATM 3174 O O3  . 117 B 2 .   ? 115.444 88.37   108.739 1 78.664  ? 901 117 A O3  1 
HETATM 3175 C C1  . 117 B 2 .   ? 113.022 88.275  107.377 1 86.189  ? 901 117 A C1  1 
HETATM 3176 C C2  . 117 B 2 .   ? 114.272 88.9    106.764 1 79.758  ? 901 117 A C2  1 
HETATM 3177 C C3  . 117 B 2 .   ? 115.513 88.253  107.338 1 77.368  ? 901 117 A C3  1 
HETATM 3178 C C4  . 117 B 2 .   ? 116.842 88.84   106.869 1 72.043  ? 901 117 A C4  1 
HETATM 3179 C C5  . 117 B 2 .   ? 118.048 88.428  107.722 1 67.246  ? 901 117 A C5  1 
HETATM 3180 C C6  . 117 B 2 .   ? 118.367 86.964  107.581 1 65.453  ? 901 117 A C6  1 
HETATM 3181 C C7  . 117 B 2 .   ? 119.354 86.449  108.61  1 63.017  ? 901 117 A C7  1 
HETATM 3182 N N1  . 117 B 2 .   ? 119.439 84.985  108.627 1 59.22   ? 901 117 A N1  1 
HETATM 3183 C C10 . 117 B 2 .   ? 119.197 82.875  109.343 1 62.72   ? 901 117 A C10 1 
HETATM 3184 C C11 . 117 B 2 .   ? 119.984 82.848  108.141 1 75.156  ? 901 117 A C11 1 
HETATM 3185 C C18 . 117 B 2 .   ? 120.551 81.691  107.441 1 73.485  ? 901 117 A C18 1 
HETATM 3186 N N2  . 117 B 2 .   ? 121.665 81.185  107.963 1 75.751  ? 901 117 A N2  1 
HETATM 3187 O O18 . 117 B 2 .   ? 119.979 81.214  106.459 1 84.243  ? 901 117 A O18 1 
HETATM 3188 C C9  . 117 B 2 .   ? 120.22  84.171  107.787 1 72.111  ? 901 117 A C9  1 
HETATM 3189 C C91 . 117 B 2 .   ? 121.025 84.755  106.647 1 74.438  ? 901 117 A C91 1 
HETATM 3190 C C93 . 117 B 2 .   ? 122.504 84.398  106.826 1 84.888  ? 901 117 A C93 1 
HETATM 3191 C C92 . 117 B 2 .   ? 120.504 84.325  105.266 1 72.658  ? 901 117 A C92 1 
HETATM 3192 O O5  . 117 B 2 .   ? 119.197 89.224  107.364 1 68.085  ? 901 117 A O5  1 
# 
