data_9OR7
# 
_entry.id   9OR7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9OR7         pdb_00009or7 10.2210/pdb9or7/pdb 
WWPDB D_1000296156 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9OR7 
_pdbx_database_status.recvd_initial_deposition_date   2025-05-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Same protein in apo-form'                    9OQE unspecified 
PDB 'Same protein co-crystallized with avibactam' 9OR3 unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jrodriguez@mbi.ucla.edu 
_pdbx_contact_author.name_first         Jose 
_pdbx_contact_author.name_last          Rodriguez 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0248-4964 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Vlahakis, N.W.'  1 ? 
'Rodriguez, J.A.' 2 ? 
'Jacobs, L.M.C.'  3 ? 
'Chen, Y.'        4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Vlahakis, N.W.'  1  ? 
primary 'Flowers, C.W.'   2  ? 
primary 'Liu, M.'         3  ? 
primary 'Agdanowski, M.'  4  ? 
primary 'Johnson, S.'     5  ? 
primary 'Summers, J.A.'   6  ? 
primary 'Jacobs, L.M.C.'  7  ? 
primary 'Keyser, C.'      8  ? 
primary 'Russell, P.'     9  ? 
primary 'Rose, S.'        10 ? 
primary 'Orlans, J.'      11 ? 
primary 'Adhami, N.'      12 ? 
primary 'Chen, Y.'        13 ? 
primary 'Sawaya, M.R.'    14 ? 
primary 'Basu, S.'        15 ? 
primary 'De Sanctis, D.'  16 ? 
primary 'Chen, Y.'        17 ? 
primary 'Wakatsuki, S.'   18 ? 
primary 'Nelson, H.M.'    19 ? 
primary 'Loo, J.A.'       20 ? 
primary 'Tang, Y.'        21 ? 
primary 'Rodriguez, J.A.' 22 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Beta-lactamase                                                 28000.547 2   3.5.2.6 ? 'UNP residues 23-284' ? 
2 non-polymer syn '(2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide' 267.260   2   ?       ? ?                     ? 
3 non-polymer syn 'PHOSPHATE ION'                                                94.971    3   ?       ? ?                     ? 
4 water       nat water                                                          18.015    667 ?       ? ?                     ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide' NXL 
3 'PHOSPHATE ION'                                                PO4 
4 water                                                          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   THR n 
1 3   SER n 
1 4   ALA n 
1 5   VAL n 
1 6   GLN n 
1 7   GLN n 
1 8   LYS n 
1 9   LEU n 
1 10  ALA n 
1 11  ALA n 
1 12  LEU n 
1 13  GLU n 
1 14  LYS n 
1 15  SER n 
1 16  SER n 
1 17  GLY n 
1 18  GLY n 
1 19  ARG n 
1 20  LEU n 
1 21  GLY n 
1 22  VAL n 
1 23  ALA n 
1 24  LEU n 
1 25  ILE n 
1 26  ASP n 
1 27  THR n 
1 28  ALA n 
1 29  ASP n 
1 30  ASN n 
1 31  THR n 
1 32  GLN n 
1 33  VAL n 
1 34  LEU n 
1 35  TYR n 
1 36  ARG n 
1 37  GLY n 
1 38  ASP n 
1 39  GLU n 
1 40  ARG n 
1 41  PHE n 
1 42  PRO n 
1 43  MET n 
1 44  CYS n 
1 45  SER n 
1 46  THR n 
1 47  SER n 
1 48  LYS n 
1 49  VAL n 
1 50  MET n 
1 51  ALA n 
1 52  ALA n 
1 53  ALA n 
1 54  ALA n 
1 55  VAL n 
1 56  LEU n 
1 57  LYS n 
1 58  GLN n 
1 59  SER n 
1 60  GLU n 
1 61  THR n 
1 62  GLN n 
1 63  LYS n 
1 64  GLN n 
1 65  LEU n 
1 66  LEU n 
1 67  ASN n 
1 68  GLN n 
1 69  PRO n 
1 70  VAL n 
1 71  GLU n 
1 72  ILE n 
1 73  LYS n 
1 74  PRO n 
1 75  ALA n 
1 76  ASP n 
1 77  LEU n 
1 78  VAL n 
1 79  ASN n 
1 80  TYR n 
1 81  ASN n 
1 82  PRO n 
1 83  ILE n 
1 84  ALA n 
1 85  GLU n 
1 86  LYS n 
1 87  HIS n 
1 88  VAL n 
1 89  ASN n 
1 90  GLY n 
1 91  THR n 
1 92  MET n 
1 93  THR n 
1 94  LEU n 
1 95  ALA n 
1 96  GLU n 
1 97  LEU n 
1 98  SER n 
1 99  ALA n 
1 100 ALA n 
1 101 ALA n 
1 102 LEU n 
1 103 GLN n 
1 104 TYR n 
1 105 SER n 
1 106 ASP n 
1 107 ASN n 
1 108 THR n 
1 109 ALA n 
1 110 MET n 
1 111 ASN n 
1 112 LYS n 
1 113 LEU n 
1 114 ILE n 
1 115 ALA n 
1 116 GLN n 
1 117 LEU n 
1 118 GLY n 
1 119 GLY n 
1 120 PRO n 
1 121 GLY n 
1 122 GLY n 
1 123 VAL n 
1 124 THR n 
1 125 ALA n 
1 126 PHE n 
1 127 ALA n 
1 128 ARG n 
1 129 ALA n 
1 130 ILE n 
1 131 GLY n 
1 132 ASP n 
1 133 GLU n 
1 134 THR n 
1 135 PHE n 
1 136 ARG n 
1 137 LEU n 
1 138 ASP n 
1 139 ARG n 
1 140 THR n 
1 141 GLU n 
1 142 PRO n 
1 143 THR n 
1 144 LEU n 
1 145 ASN n 
1 146 THR n 
1 147 ALA n 
1 148 ILE n 
1 149 PRO n 
1 150 GLY n 
1 151 ASP n 
1 152 PRO n 
1 153 ARG n 
1 154 ASP n 
1 155 THR n 
1 156 THR n 
1 157 THR n 
1 158 PRO n 
1 159 ARG n 
1 160 ALA n 
1 161 MET n 
1 162 ALA n 
1 163 GLN n 
1 164 THR n 
1 165 LEU n 
1 166 ARG n 
1 167 GLN n 
1 168 LEU n 
1 169 THR n 
1 170 LEU n 
1 171 GLY n 
1 172 HIS n 
1 173 ALA n 
1 174 LEU n 
1 175 GLY n 
1 176 GLU n 
1 177 THR n 
1 178 GLN n 
1 179 ARG n 
1 180 ALA n 
1 181 GLN n 
1 182 LEU n 
1 183 VAL n 
1 184 THR n 
1 185 TRP n 
1 186 LEU n 
1 187 LYS n 
1 188 GLY n 
1 189 ASN n 
1 190 THR n 
1 191 THR n 
1 192 GLY n 
1 193 ALA n 
1 194 ALA n 
1 195 SER n 
1 196 ILE n 
1 197 ARG n 
1 198 ALA n 
1 199 GLY n 
1 200 LEU n 
1 201 PRO n 
1 202 THR n 
1 203 SER n 
1 204 TRP n 
1 205 THR n 
1 206 VAL n 
1 207 GLY n 
1 208 ASP n 
1 209 LYS n 
1 210 THR n 
1 211 GLY n 
1 212 SER n 
1 213 GLY n 
1 214 ASP n 
1 215 TYR n 
1 216 GLY n 
1 217 THR n 
1 218 THR n 
1 219 ASN n 
1 220 ASP n 
1 221 ILE n 
1 222 ALA n 
1 223 VAL n 
1 224 ILE n 
1 225 TRP n 
1 226 PRO n 
1 227 GLN n 
1 228 GLY n 
1 229 ARG n 
1 230 ALA n 
1 231 PRO n 
1 232 LEU n 
1 233 VAL n 
1 234 LEU n 
1 235 VAL n 
1 236 THR n 
1 237 TYR n 
1 238 PHE n 
1 239 THR n 
1 240 GLN n 
1 241 PRO n 
1 242 GLN n 
1 243 GLN n 
1 244 ASN n 
1 245 ALA n 
1 246 GLU n 
1 247 SER n 
1 248 ARG n 
1 249 ARG n 
1 250 ASP n 
1 251 VAL n 
1 252 LEU n 
1 253 ALA n 
1 254 SER n 
1 255 ALA n 
1 256 ALA n 
1 257 ARG n 
1 258 ILE n 
1 259 ILE n 
1 260 ALA n 
1 261 GLU n 
1 262 GLY n 
1 263 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   263 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 
;blaCTX-M-14, beta-lactamase CTX-M-14, bla, bla CTX-M-14, bla-CTX-M-14a, blaCTX-M, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, AM340_28340, AM465_01285, AM465_06510, AM465_23360, APT94_14605, BEN53_26220, BJJ90_27545, BK334_27290, BOH76_00730, BON63_16015, BON65_15195, BON66_01305, BON69_22545, BON72_03470, BON75_10525, BON76_14325, BON83_15455, BON86_08515, BON91_02075, BON92_04750, BON94_23850, BON95_01680, BON96_03940, BON98_23175, BXT93_06855, C5N07_28500, CDL37_21060, CR538_26855, DW236_20870, E4K51_21070, EIA08_25160, EIA21_26975, ELT23_05930, ELV24_09995, ELX61_24095, EST51_15935, EST51_18575, EST51_22260, EST51_22365, ETN48_p0088, FNJ69_13810, FTV90_03295, GE096_24920, GE096_25355, GQE36_23945, HGR36_01450, HGR36_27140, HHH24_004455, HHH24_005319, HJI79_003882, HJI79_004995, HK427_004976, HK427_005087, HL152_24835, HL152_25835, HL563_21800, HL563_23665, HLT96_25270, HLT96_28700, HLU13_27785, HLY53_18605, HLY53_26190, HLZ85_26065, HMW26_20895, HMW26_29355, HNC73_28650, HNC75_27190, HNC75_29165, HNC80_26145, HNC80_27675, HNC88_26185, HNC88_27880, HND23_26750, HND23_28285, HNV91_23425, HNV91_24920, HNV94_24095, HNV94_27845, pCT_085, pHK01_011, RCS103_P0010, RCS30_P0082, RCS56_P0085, RCS60_P0031, RCS63_P0006, RCS65_P0008, RCS66_P0053, SAMEA4362930_00013, SAMEA4363083_00099, SAMEA4370290_00046, WP4S18E07_P40650, WP7S17E01_P10270, WP7S18E09_37980
;
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     562 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                        ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                       ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                     ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                       ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                      ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                        ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                      ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                          ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                     ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                        ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                         ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                     ? 'C5 H11 N O2 S'  149.211 
NXL non-polymer         . '(2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide' 
'avibactam, bound form; NXL104, bound form' 'C7 H13 N3 O6 S' 267.260 
PHE 'L-peptide linking' y PHENYLALANINE                                                  ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                        ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                         ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                      ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                     ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                       ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                         ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   25  ?   ?   ?   A . n 
A 1 2   THR 2   26  ?   ?   ?   A . n 
A 1 3   SER 3   27  27  SER SER A . n 
A 1 4   ALA 4   28  28  ALA ALA A . n 
A 1 5   VAL 5   29  29  VAL VAL A . n 
A 1 6   GLN 6   30  30  GLN GLN A . n 
A 1 7   GLN 7   31  31  GLN GLN A . n 
A 1 8   LYS 8   32  32  LYS LYS A . n 
A 1 9   LEU 9   33  33  LEU LEU A . n 
A 1 10  ALA 10  34  34  ALA ALA A . n 
A 1 11  ALA 11  35  35  ALA ALA A . n 
A 1 12  LEU 12  36  36  LEU LEU A . n 
A 1 13  GLU 13  37  37  GLU GLU A . n 
A 1 14  LYS 14  38  38  LYS LYS A . n 
A 1 15  SER 15  39  39  SER SER A . n 
A 1 16  SER 16  40  40  SER SER A . n 
A 1 17  GLY 17  41  41  GLY GLY A . n 
A 1 18  GLY 18  42  42  GLY GLY A . n 
A 1 19  ARG 19  43  43  ARG ARG A . n 
A 1 20  LEU 20  44  44  LEU LEU A . n 
A 1 21  GLY 21  45  45  GLY GLY A . n 
A 1 22  VAL 22  46  46  VAL VAL A . n 
A 1 23  ALA 23  47  47  ALA ALA A . n 
A 1 24  LEU 24  48  48  LEU LEU A . n 
A 1 25  ILE 25  49  49  ILE ILE A . n 
A 1 26  ASP 26  50  50  ASP ASP A . n 
A 1 27  THR 27  51  51  THR THR A . n 
A 1 28  ALA 28  52  52  ALA ALA A . n 
A 1 29  ASP 29  53  53  ASP ASP A . n 
A 1 30  ASN 30  54  54  ASN ASN A . n 
A 1 31  THR 31  55  55  THR THR A . n 
A 1 32  GLN 32  56  56  GLN GLN A . n 
A 1 33  VAL 33  57  57  VAL VAL A . n 
A 1 34  LEU 34  59  59  LEU LEU A . n 
A 1 35  TYR 35  60  60  TYR TYR A . n 
A 1 36  ARG 36  61  61  ARG ARG A . n 
A 1 37  GLY 37  62  62  GLY GLY A . n 
A 1 38  ASP 38  63  63  ASP ASP A . n 
A 1 39  GLU 39  64  64  GLU GLU A . n 
A 1 40  ARG 40  65  65  ARG ARG A . n 
A 1 41  PHE 41  66  66  PHE PHE A . n 
A 1 42  PRO 42  67  67  PRO PRO A . n 
A 1 43  MET 43  68  68  MET MET A . n 
A 1 44  CYS 44  69  69  CYS CYS A . n 
A 1 45  SER 45  70  70  SER SER A . n 
A 1 46  THR 46  71  71  THR THR A . n 
A 1 47  SER 47  72  72  SER SER A . n 
A 1 48  LYS 48  73  73  LYS LYS A . n 
A 1 49  VAL 49  74  74  VAL VAL A . n 
A 1 50  MET 50  75  75  MET MET A . n 
A 1 51  ALA 51  76  76  ALA ALA A . n 
A 1 52  ALA 52  77  77  ALA ALA A . n 
A 1 53  ALA 53  78  78  ALA ALA A . n 
A 1 54  ALA 54  79  79  ALA ALA A . n 
A 1 55  VAL 55  80  80  VAL VAL A . n 
A 1 56  LEU 56  81  81  LEU LEU A . n 
A 1 57  LYS 57  82  82  LYS LYS A . n 
A 1 58  GLN 58  83  83  GLN GLN A . n 
A 1 59  SER 59  84  84  SER SER A . n 
A 1 60  GLU 60  85  85  GLU GLU A . n 
A 1 61  THR 61  86  86  THR THR A . n 
A 1 62  GLN 62  87  87  GLN GLN A . n 
A 1 63  LYS 63  88  88  LYS LYS A . n 
A 1 64  GLN 64  89  89  GLN GLN A . n 
A 1 65  LEU 65  90  90  LEU LEU A . n 
A 1 66  LEU 66  91  91  LEU LEU A . n 
A 1 67  ASN 67  92  92  ASN ASN A . n 
A 1 68  GLN 68  93  93  GLN GLN A . n 
A 1 69  PRO 69  94  94  PRO PRO A . n 
A 1 70  VAL 70  95  95  VAL VAL A . n 
A 1 71  GLU 71  96  96  GLU GLU A . n 
A 1 72  ILE 72  97  97  ILE ILE A . n 
A 1 73  LYS 73  98  98  LYS LYS A . n 
A 1 74  PRO 74  99  99  PRO PRO A . n 
A 1 75  ALA 75  100 100 ALA ALA A . n 
A 1 76  ASP 76  101 101 ASP ASP A . n 
A 1 77  LEU 77  102 102 LEU LEU A . n 
A 1 78  VAL 78  103 103 VAL VAL A . n 
A 1 79  ASN 79  104 104 ASN ASN A . n 
A 1 80  TYR 80  105 105 TYR TYR A . n 
A 1 81  ASN 81  106 106 ASN ASN A . n 
A 1 82  PRO 82  107 107 PRO PRO A . n 
A 1 83  ILE 83  108 108 ILE ILE A . n 
A 1 84  ALA 84  109 109 ALA ALA A . n 
A 1 85  GLU 85  110 110 GLU GLU A . n 
A 1 86  LYS 86  111 111 LYS LYS A . n 
A 1 87  HIS 87  112 112 HIS HIS A . n 
A 1 88  VAL 88  113 113 VAL VAL A . n 
A 1 89  ASN 89  114 114 ASN ASN A . n 
A 1 90  GLY 90  115 115 GLY GLY A . n 
A 1 91  THR 91  116 116 THR THR A . n 
A 1 92  MET 92  117 117 MET MET A . n 
A 1 93  THR 93  118 118 THR THR A . n 
A 1 94  LEU 94  119 119 LEU LEU A . n 
A 1 95  ALA 95  120 120 ALA ALA A . n 
A 1 96  GLU 96  121 121 GLU GLU A . n 
A 1 97  LEU 97  122 122 LEU LEU A . n 
A 1 98  SER 98  123 123 SER SER A . n 
A 1 99  ALA 99  124 124 ALA ALA A . n 
A 1 100 ALA 100 125 125 ALA ALA A . n 
A 1 101 ALA 101 126 126 ALA ALA A . n 
A 1 102 LEU 102 127 127 LEU LEU A . n 
A 1 103 GLN 103 128 128 GLN GLN A . n 
A 1 104 TYR 104 129 129 TYR TYR A . n 
A 1 105 SER 105 130 130 SER SER A . n 
A 1 106 ASP 106 131 131 ASP ASP A . n 
A 1 107 ASN 107 132 132 ASN ASN A . n 
A 1 108 THR 108 133 133 THR THR A . n 
A 1 109 ALA 109 134 134 ALA ALA A . n 
A 1 110 MET 110 135 135 MET MET A . n 
A 1 111 ASN 111 136 136 ASN ASN A . n 
A 1 112 LYS 112 137 137 LYS LYS A . n 
A 1 113 LEU 113 138 138 LEU LEU A . n 
A 1 114 ILE 114 139 139 ILE ILE A . n 
A 1 115 ALA 115 140 140 ALA ALA A . n 
A 1 116 GLN 116 141 141 GLN GLN A . n 
A 1 117 LEU 117 142 142 LEU LEU A . n 
A 1 118 GLY 118 143 143 GLY GLY A . n 
A 1 119 GLY 119 144 144 GLY GLY A . n 
A 1 120 PRO 120 145 145 PRO PRO A . n 
A 1 121 GLY 121 146 146 GLY GLY A . n 
A 1 122 GLY 122 147 147 GLY GLY A . n 
A 1 123 VAL 123 148 148 VAL VAL A . n 
A 1 124 THR 124 149 149 THR THR A . n 
A 1 125 ALA 125 150 150 ALA ALA A . n 
A 1 126 PHE 126 151 151 PHE PHE A . n 
A 1 127 ALA 127 152 152 ALA ALA A . n 
A 1 128 ARG 128 153 153 ARG ARG A . n 
A 1 129 ALA 129 154 154 ALA ALA A . n 
A 1 130 ILE 130 155 155 ILE ILE A . n 
A 1 131 GLY 131 156 156 GLY GLY A . n 
A 1 132 ASP 132 157 157 ASP ASP A . n 
A 1 133 GLU 133 158 158 GLU GLU A . n 
A 1 134 THR 134 159 159 THR THR A . n 
A 1 135 PHE 135 160 160 PHE PHE A . n 
A 1 136 ARG 136 161 161 ARG ARG A . n 
A 1 137 LEU 137 162 162 LEU LEU A . n 
A 1 138 ASP 138 163 163 ASP ASP A . n 
A 1 139 ARG 139 164 164 ARG ARG A . n 
A 1 140 THR 140 165 165 THR THR A . n 
A 1 141 GLU 141 166 166 GLU GLU A . n 
A 1 142 PRO 142 167 167 PRO PRO A . n 
A 1 143 THR 143 168 168 THR THR A . n 
A 1 144 LEU 144 169 169 LEU LEU A . n 
A 1 145 ASN 145 170 170 ASN ASN A . n 
A 1 146 THR 146 171 171 THR THR A . n 
A 1 147 ALA 147 172 172 ALA ALA A . n 
A 1 148 ILE 148 173 173 ILE ILE A . n 
A 1 149 PRO 149 174 174 PRO PRO A . n 
A 1 150 GLY 150 175 175 GLY GLY A . n 
A 1 151 ASP 151 176 176 ASP ASP A . n 
A 1 152 PRO 152 177 177 PRO PRO A . n 
A 1 153 ARG 153 178 178 ARG ARG A . n 
A 1 154 ASP 154 179 179 ASP ASP A . n 
A 1 155 THR 155 180 180 THR THR A . n 
A 1 156 THR 156 181 181 THR THR A . n 
A 1 157 THR 157 182 182 THR THR A . n 
A 1 158 PRO 158 183 183 PRO PRO A . n 
A 1 159 ARG 159 184 184 ARG ARG A . n 
A 1 160 ALA 160 185 185 ALA ALA A . n 
A 1 161 MET 161 186 186 MET MET A . n 
A 1 162 ALA 162 187 187 ALA ALA A . n 
A 1 163 GLN 163 188 188 GLN GLN A . n 
A 1 164 THR 164 189 189 THR THR A . n 
A 1 165 LEU 165 190 190 LEU LEU A . n 
A 1 166 ARG 166 191 191 ARG ARG A . n 
A 1 167 GLN 167 192 192 GLN GLN A . n 
A 1 168 LEU 168 193 193 LEU LEU A . n 
A 1 169 THR 169 194 194 THR THR A . n 
A 1 170 LEU 170 195 195 LEU LEU A . n 
A 1 171 GLY 171 196 196 GLY GLY A . n 
A 1 172 HIS 172 197 197 HIS HIS A . n 
A 1 173 ALA 173 198 198 ALA ALA A . n 
A 1 174 LEU 174 199 199 LEU LEU A . n 
A 1 175 GLY 175 200 200 GLY GLY A . n 
A 1 176 GLU 176 201 201 GLU GLU A . n 
A 1 177 THR 177 202 202 THR THR A . n 
A 1 178 GLN 178 203 203 GLN GLN A . n 
A 1 179 ARG 179 204 204 ARG ARG A . n 
A 1 180 ALA 180 205 205 ALA ALA A . n 
A 1 181 GLN 181 206 206 GLN GLN A . n 
A 1 182 LEU 182 207 207 LEU LEU A . n 
A 1 183 VAL 183 208 208 VAL VAL A . n 
A 1 184 THR 184 209 209 THR THR A . n 
A 1 185 TRP 185 210 210 TRP TRP A . n 
A 1 186 LEU 186 211 211 LEU LEU A . n 
A 1 187 LYS 187 212 212 LYS LYS A . n 
A 1 188 GLY 188 213 213 GLY GLY A . n 
A 1 189 ASN 189 214 214 ASN ASN A . n 
A 1 190 THR 190 215 215 THR THR A . n 
A 1 191 THR 191 216 216 THR THR A . n 
A 1 192 GLY 192 217 217 GLY GLY A . n 
A 1 193 ALA 193 218 218 ALA ALA A . n 
A 1 194 ALA 194 219 219 ALA ALA A . n 
A 1 195 SER 195 220 220 SER SER A . n 
A 1 196 ILE 196 221 221 ILE ILE A . n 
A 1 197 ARG 197 222 222 ARG ARG A . n 
A 1 198 ALA 198 223 223 ALA ALA A . n 
A 1 199 GLY 199 224 224 GLY GLY A . n 
A 1 200 LEU 200 225 225 LEU LEU A . n 
A 1 201 PRO 201 226 226 PRO PRO A . n 
A 1 202 THR 202 227 227 THR THR A . n 
A 1 203 SER 203 228 228 SER SER A . n 
A 1 204 TRP 204 229 229 TRP TRP A . n 
A 1 205 THR 205 230 230 THR THR A . n 
A 1 206 VAL 206 231 231 VAL VAL A . n 
A 1 207 GLY 207 232 232 GLY GLY A . n 
A 1 208 ASP 208 233 233 ASP ASP A . n 
A 1 209 LYS 209 234 234 LYS LYS A . n 
A 1 210 THR 210 235 235 THR THR A . n 
A 1 211 GLY 211 236 236 GLY GLY A . n 
A 1 212 SER 212 237 237 SER SER A . n 
A 1 213 GLY 213 238 238 GLY GLY A . n 
A 1 214 ASP 214 240 240 ASP ASP A . n 
A 1 215 TYR 215 241 241 TYR TYR A . n 
A 1 216 GLY 216 242 242 GLY GLY A . n 
A 1 217 THR 217 243 243 THR THR A . n 
A 1 218 THR 218 244 244 THR THR A . n 
A 1 219 ASN 219 245 245 ASN ASN A . n 
A 1 220 ASP 220 246 246 ASP ASP A . n 
A 1 221 ILE 221 247 247 ILE ILE A . n 
A 1 222 ALA 222 248 248 ALA ALA A . n 
A 1 223 VAL 223 249 249 VAL VAL A . n 
A 1 224 ILE 224 250 250 ILE ILE A . n 
A 1 225 TRP 225 251 251 TRP TRP A . n 
A 1 226 PRO 226 252 252 PRO PRO A . n 
A 1 227 GLN 227 254 254 GLN GLN A . n 
A 1 228 GLY 228 255 255 GLY GLY A . n 
A 1 229 ARG 229 256 256 ARG ARG A . n 
A 1 230 ALA 230 257 257 ALA ALA A . n 
A 1 231 PRO 231 258 258 PRO PRO A . n 
A 1 232 LEU 232 259 259 LEU LEU A . n 
A 1 233 VAL 233 260 260 VAL VAL A . n 
A 1 234 LEU 234 261 261 LEU LEU A . n 
A 1 235 VAL 235 262 262 VAL VAL A . n 
A 1 236 THR 236 263 263 THR THR A . n 
A 1 237 TYR 237 264 264 TYR TYR A . n 
A 1 238 PHE 238 265 265 PHE PHE A . n 
A 1 239 THR 239 266 266 THR THR A . n 
A 1 240 GLN 240 267 267 GLN GLN A . n 
A 1 241 PRO 241 268 268 PRO PRO A . n 
A 1 242 GLN 242 269 269 GLN GLN A . n 
A 1 243 GLN 243 270 270 GLN GLN A . n 
A 1 244 ASN 244 271 271 ASN ASN A . n 
A 1 245 ALA 245 272 272 ALA ALA A . n 
A 1 246 GLU 246 273 273 GLU GLU A . n 
A 1 247 SER 247 274 274 SER SER A . n 
A 1 248 ARG 248 275 275 ARG ARG A . n 
A 1 249 ARG 249 276 276 ARG ARG A . n 
A 1 250 ASP 250 277 277 ASP ASP A . n 
A 1 251 VAL 251 278 278 VAL VAL A . n 
A 1 252 LEU 252 279 279 LEU LEU A . n 
A 1 253 ALA 253 280 280 ALA ALA A . n 
A 1 254 SER 254 281 281 SER SER A . n 
A 1 255 ALA 255 282 282 ALA ALA A . n 
A 1 256 ALA 256 283 283 ALA ALA A . n 
A 1 257 ARG 257 284 284 ARG ARG A . n 
A 1 258 ILE 258 285 285 ILE ILE A . n 
A 1 259 ILE 259 286 286 ILE ILE A . n 
A 1 260 ALA 260 287 287 ALA ALA A . n 
A 1 261 GLU 261 288 288 GLU GLU A . n 
A 1 262 GLY 262 289 289 GLY GLY A . n 
A 1 263 LEU 263 290 290 LEU LEU A . n 
B 1 1   GLN 1   25  25  GLN GLN B . n 
B 1 2   THR 2   26  26  THR THR B . n 
B 1 3   SER 3   27  27  SER SER B . n 
B 1 4   ALA 4   28  28  ALA ALA B . n 
B 1 5   VAL 5   29  29  VAL VAL B . n 
B 1 6   GLN 6   30  30  GLN GLN B . n 
B 1 7   GLN 7   31  31  GLN GLN B . n 
B 1 8   LYS 8   32  32  LYS LYS B . n 
B 1 9   LEU 9   33  33  LEU LEU B . n 
B 1 10  ALA 10  34  34  ALA ALA B . n 
B 1 11  ALA 11  35  35  ALA ALA B . n 
B 1 12  LEU 12  36  36  LEU LEU B . n 
B 1 13  GLU 13  37  37  GLU GLU B . n 
B 1 14  LYS 14  38  38  LYS LYS B . n 
B 1 15  SER 15  39  39  SER SER B . n 
B 1 16  SER 16  40  40  SER SER B . n 
B 1 17  GLY 17  41  41  GLY GLY B . n 
B 1 18  GLY 18  42  42  GLY GLY B . n 
B 1 19  ARG 19  43  43  ARG ARG B . n 
B 1 20  LEU 20  44  44  LEU LEU B . n 
B 1 21  GLY 21  45  45  GLY GLY B . n 
B 1 22  VAL 22  46  46  VAL VAL B . n 
B 1 23  ALA 23  47  47  ALA ALA B . n 
B 1 24  LEU 24  48  48  LEU LEU B . n 
B 1 25  ILE 25  49  49  ILE ILE B . n 
B 1 26  ASP 26  50  50  ASP ASP B . n 
B 1 27  THR 27  51  51  THR THR B . n 
B 1 28  ALA 28  52  52  ALA ALA B . n 
B 1 29  ASP 29  53  53  ASP ASP B . n 
B 1 30  ASN 30  54  54  ASN ASN B . n 
B 1 31  THR 31  55  55  THR THR B . n 
B 1 32  GLN 32  56  56  GLN GLN B . n 
B 1 33  VAL 33  57  57  VAL VAL B . n 
B 1 34  LEU 34  59  59  LEU LEU B . n 
B 1 35  TYR 35  60  60  TYR TYR B . n 
B 1 36  ARG 36  61  61  ARG ARG B . n 
B 1 37  GLY 37  62  62  GLY GLY B . n 
B 1 38  ASP 38  63  63  ASP ASP B . n 
B 1 39  GLU 39  64  64  GLU GLU B . n 
B 1 40  ARG 40  65  65  ARG ARG B . n 
B 1 41  PHE 41  66  66  PHE PHE B . n 
B 1 42  PRO 42  67  67  PRO PRO B . n 
B 1 43  MET 43  68  68  MET MET B . n 
B 1 44  CYS 44  69  69  CYS CYS B . n 
B 1 45  SER 45  70  70  SER SER B . n 
B 1 46  THR 46  71  71  THR THR B . n 
B 1 47  SER 47  72  72  SER SER B . n 
B 1 48  LYS 48  73  73  LYS LYS B . n 
B 1 49  VAL 49  74  74  VAL VAL B . n 
B 1 50  MET 50  75  75  MET MET B . n 
B 1 51  ALA 51  76  76  ALA ALA B . n 
B 1 52  ALA 52  77  77  ALA ALA B . n 
B 1 53  ALA 53  78  78  ALA ALA B . n 
B 1 54  ALA 54  79  79  ALA ALA B . n 
B 1 55  VAL 55  80  80  VAL VAL B . n 
B 1 56  LEU 56  81  81  LEU LEU B . n 
B 1 57  LYS 57  82  82  LYS LYS B . n 
B 1 58  GLN 58  83  83  GLN GLN B . n 
B 1 59  SER 59  84  84  SER SER B . n 
B 1 60  GLU 60  85  85  GLU GLU B . n 
B 1 61  THR 61  86  86  THR THR B . n 
B 1 62  GLN 62  87  87  GLN GLN B . n 
B 1 63  LYS 63  88  88  LYS LYS B . n 
B 1 64  GLN 64  89  89  GLN GLN B . n 
B 1 65  LEU 65  90  90  LEU LEU B . n 
B 1 66  LEU 66  91  91  LEU LEU B . n 
B 1 67  ASN 67  92  92  ASN ASN B . n 
B 1 68  GLN 68  93  93  GLN GLN B . n 
B 1 69  PRO 69  94  94  PRO PRO B . n 
B 1 70  VAL 70  95  95  VAL VAL B . n 
B 1 71  GLU 71  96  96  GLU GLU B . n 
B 1 72  ILE 72  97  97  ILE ILE B . n 
B 1 73  LYS 73  98  98  LYS LYS B . n 
B 1 74  PRO 74  99  99  PRO PRO B . n 
B 1 75  ALA 75  100 100 ALA ALA B . n 
B 1 76  ASP 76  101 101 ASP ASP B . n 
B 1 77  LEU 77  102 102 LEU LEU B . n 
B 1 78  VAL 78  103 103 VAL VAL B . n 
B 1 79  ASN 79  104 104 ASN ASN B . n 
B 1 80  TYR 80  105 105 TYR TYR B . n 
B 1 81  ASN 81  106 106 ASN ASN B . n 
B 1 82  PRO 82  107 107 PRO PRO B . n 
B 1 83  ILE 83  108 108 ILE ILE B . n 
B 1 84  ALA 84  109 109 ALA ALA B . n 
B 1 85  GLU 85  110 110 GLU GLU B . n 
B 1 86  LYS 86  111 111 LYS LYS B . n 
B 1 87  HIS 87  112 112 HIS HIS B . n 
B 1 88  VAL 88  113 113 VAL VAL B . n 
B 1 89  ASN 89  114 114 ASN ASN B . n 
B 1 90  GLY 90  115 115 GLY GLY B . n 
B 1 91  THR 91  116 116 THR THR B . n 
B 1 92  MET 92  117 117 MET MET B . n 
B 1 93  THR 93  118 118 THR THR B . n 
B 1 94  LEU 94  119 119 LEU LEU B . n 
B 1 95  ALA 95  120 120 ALA ALA B . n 
B 1 96  GLU 96  121 121 GLU GLU B . n 
B 1 97  LEU 97  122 122 LEU LEU B . n 
B 1 98  SER 98  123 123 SER SER B . n 
B 1 99  ALA 99  124 124 ALA ALA B . n 
B 1 100 ALA 100 125 125 ALA ALA B . n 
B 1 101 ALA 101 126 126 ALA ALA B . n 
B 1 102 LEU 102 127 127 LEU LEU B . n 
B 1 103 GLN 103 128 128 GLN GLN B . n 
B 1 104 TYR 104 129 129 TYR TYR B . n 
B 1 105 SER 105 130 130 SER SER B . n 
B 1 106 ASP 106 131 131 ASP ASP B . n 
B 1 107 ASN 107 132 132 ASN ASN B . n 
B 1 108 THR 108 133 133 THR THR B . n 
B 1 109 ALA 109 134 134 ALA ALA B . n 
B 1 110 MET 110 135 135 MET MET B . n 
B 1 111 ASN 111 136 136 ASN ASN B . n 
B 1 112 LYS 112 137 137 LYS LYS B . n 
B 1 113 LEU 113 138 138 LEU LEU B . n 
B 1 114 ILE 114 139 139 ILE ILE B . n 
B 1 115 ALA 115 140 140 ALA ALA B . n 
B 1 116 GLN 116 141 141 GLN GLN B . n 
B 1 117 LEU 117 142 142 LEU LEU B . n 
B 1 118 GLY 118 143 143 GLY GLY B . n 
B 1 119 GLY 119 144 144 GLY GLY B . n 
B 1 120 PRO 120 145 145 PRO PRO B . n 
B 1 121 GLY 121 146 146 GLY GLY B . n 
B 1 122 GLY 122 147 147 GLY GLY B . n 
B 1 123 VAL 123 148 148 VAL VAL B . n 
B 1 124 THR 124 149 149 THR THR B . n 
B 1 125 ALA 125 150 150 ALA ALA B . n 
B 1 126 PHE 126 151 151 PHE PHE B . n 
B 1 127 ALA 127 152 152 ALA ALA B . n 
B 1 128 ARG 128 153 153 ARG ARG B . n 
B 1 129 ALA 129 154 154 ALA ALA B . n 
B 1 130 ILE 130 155 155 ILE ILE B . n 
B 1 131 GLY 131 156 156 GLY GLY B . n 
B 1 132 ASP 132 157 157 ASP ASP B . n 
B 1 133 GLU 133 158 158 GLU GLU B . n 
B 1 134 THR 134 159 159 THR THR B . n 
B 1 135 PHE 135 160 160 PHE PHE B . n 
B 1 136 ARG 136 161 161 ARG ARG B . n 
B 1 137 LEU 137 162 162 LEU LEU B . n 
B 1 138 ASP 138 163 163 ASP ASP B . n 
B 1 139 ARG 139 164 164 ARG ARG B . n 
B 1 140 THR 140 165 165 THR THR B . n 
B 1 141 GLU 141 166 166 GLU GLU B . n 
B 1 142 PRO 142 167 167 PRO PRO B . n 
B 1 143 THR 143 168 168 THR THR B . n 
B 1 144 LEU 144 169 169 LEU LEU B . n 
B 1 145 ASN 145 170 170 ASN ASN B . n 
B 1 146 THR 146 171 171 THR THR B . n 
B 1 147 ALA 147 172 172 ALA ALA B . n 
B 1 148 ILE 148 173 173 ILE ILE B . n 
B 1 149 PRO 149 174 174 PRO PRO B . n 
B 1 150 GLY 150 175 175 GLY GLY B . n 
B 1 151 ASP 151 176 176 ASP ASP B . n 
B 1 152 PRO 152 177 177 PRO PRO B . n 
B 1 153 ARG 153 178 178 ARG ARG B . n 
B 1 154 ASP 154 179 179 ASP ASP B . n 
B 1 155 THR 155 180 180 THR THR B . n 
B 1 156 THR 156 181 181 THR THR B . n 
B 1 157 THR 157 182 182 THR THR B . n 
B 1 158 PRO 158 183 183 PRO PRO B . n 
B 1 159 ARG 159 184 184 ARG ARG B . n 
B 1 160 ALA 160 185 185 ALA ALA B . n 
B 1 161 MET 161 186 186 MET MET B . n 
B 1 162 ALA 162 187 187 ALA ALA B . n 
B 1 163 GLN 163 188 188 GLN GLN B . n 
B 1 164 THR 164 189 189 THR THR B . n 
B 1 165 LEU 165 190 190 LEU LEU B . n 
B 1 166 ARG 166 191 191 ARG ARG B . n 
B 1 167 GLN 167 192 192 GLN GLN B . n 
B 1 168 LEU 168 193 193 LEU LEU B . n 
B 1 169 THR 169 194 194 THR THR B . n 
B 1 170 LEU 170 195 195 LEU LEU B . n 
B 1 171 GLY 171 196 196 GLY GLY B . n 
B 1 172 HIS 172 197 197 HIS HIS B . n 
B 1 173 ALA 173 198 198 ALA ALA B . n 
B 1 174 LEU 174 199 199 LEU LEU B . n 
B 1 175 GLY 175 200 200 GLY GLY B . n 
B 1 176 GLU 176 201 201 GLU GLU B . n 
B 1 177 THR 177 202 202 THR THR B . n 
B 1 178 GLN 178 203 203 GLN GLN B . n 
B 1 179 ARG 179 204 204 ARG ARG B . n 
B 1 180 ALA 180 205 205 ALA ALA B . n 
B 1 181 GLN 181 206 206 GLN GLN B . n 
B 1 182 LEU 182 207 207 LEU LEU B . n 
B 1 183 VAL 183 208 208 VAL VAL B . n 
B 1 184 THR 184 209 209 THR THR B . n 
B 1 185 TRP 185 210 210 TRP TRP B . n 
B 1 186 LEU 186 211 211 LEU LEU B . n 
B 1 187 LYS 187 212 212 LYS LYS B . n 
B 1 188 GLY 188 213 213 GLY GLY B . n 
B 1 189 ASN 189 214 214 ASN ASN B . n 
B 1 190 THR 190 215 215 THR THR B . n 
B 1 191 THR 191 216 216 THR THR B . n 
B 1 192 GLY 192 217 217 GLY GLY B . n 
B 1 193 ALA 193 218 218 ALA ALA B . n 
B 1 194 ALA 194 219 219 ALA ALA B . n 
B 1 195 SER 195 220 220 SER SER B . n 
B 1 196 ILE 196 221 221 ILE ILE B . n 
B 1 197 ARG 197 222 222 ARG ARG B . n 
B 1 198 ALA 198 223 223 ALA ALA B . n 
B 1 199 GLY 199 224 224 GLY GLY B . n 
B 1 200 LEU 200 225 225 LEU LEU B . n 
B 1 201 PRO 201 226 226 PRO PRO B . n 
B 1 202 THR 202 227 227 THR THR B . n 
B 1 203 SER 203 228 228 SER SER B . n 
B 1 204 TRP 204 229 229 TRP TRP B . n 
B 1 205 THR 205 230 230 THR THR B . n 
B 1 206 VAL 206 231 231 VAL VAL B . n 
B 1 207 GLY 207 232 232 GLY GLY B . n 
B 1 208 ASP 208 233 233 ASP ASP B . n 
B 1 209 LYS 209 234 234 LYS LYS B . n 
B 1 210 THR 210 235 235 THR THR B . n 
B 1 211 GLY 211 236 236 GLY GLY B . n 
B 1 212 SER 212 237 237 SER SER B . n 
B 1 213 GLY 213 238 238 GLY GLY B . n 
B 1 214 ASP 214 240 240 ASP ASP B . n 
B 1 215 TYR 215 241 241 TYR TYR B . n 
B 1 216 GLY 216 242 242 GLY GLY B . n 
B 1 217 THR 217 243 243 THR THR B . n 
B 1 218 THR 218 244 244 THR THR B . n 
B 1 219 ASN 219 245 245 ASN ASN B . n 
B 1 220 ASP 220 246 246 ASP ASP B . n 
B 1 221 ILE 221 247 247 ILE ILE B . n 
B 1 222 ALA 222 248 248 ALA ALA B . n 
B 1 223 VAL 223 249 249 VAL VAL B . n 
B 1 224 ILE 224 250 250 ILE ILE B . n 
B 1 225 TRP 225 251 251 TRP TRP B . n 
B 1 226 PRO 226 252 252 PRO PRO B . n 
B 1 227 GLN 227 254 254 GLN GLN B . n 
B 1 228 GLY 228 255 255 GLY GLY B . n 
B 1 229 ARG 229 256 256 ARG ARG B . n 
B 1 230 ALA 230 257 257 ALA ALA B . n 
B 1 231 PRO 231 258 258 PRO PRO B . n 
B 1 232 LEU 232 259 259 LEU LEU B . n 
B 1 233 VAL 233 260 260 VAL VAL B . n 
B 1 234 LEU 234 261 261 LEU LEU B . n 
B 1 235 VAL 235 262 262 VAL VAL B . n 
B 1 236 THR 236 263 263 THR THR B . n 
B 1 237 TYR 237 264 264 TYR TYR B . n 
B 1 238 PHE 238 265 265 PHE PHE B . n 
B 1 239 THR 239 266 266 THR THR B . n 
B 1 240 GLN 240 267 267 GLN GLN B . n 
B 1 241 PRO 241 268 268 PRO PRO B . n 
B 1 242 GLN 242 269 269 GLN GLN B . n 
B 1 243 GLN 243 270 270 GLN GLN B . n 
B 1 244 ASN 244 271 271 ASN ASN B . n 
B 1 245 ALA 245 272 272 ALA ALA B . n 
B 1 246 GLU 246 273 273 GLU GLU B . n 
B 1 247 SER 247 274 274 SER SER B . n 
B 1 248 ARG 248 275 275 ARG ARG B . n 
B 1 249 ARG 249 276 276 ARG ARG B . n 
B 1 250 ASP 250 277 277 ASP ASP B . n 
B 1 251 VAL 251 278 278 VAL VAL B . n 
B 1 252 LEU 252 279 279 LEU LEU B . n 
B 1 253 ALA 253 280 280 ALA ALA B . n 
B 1 254 SER 254 281 281 SER SER B . n 
B 1 255 ALA 255 282 282 ALA ALA B . n 
B 1 256 ALA 256 283 283 ALA ALA B . n 
B 1 257 ARG 257 284 284 ARG ARG B . n 
B 1 258 ILE 258 285 285 ILE ILE B . n 
B 1 259 ILE 259 286 286 ILE ILE B . n 
B 1 260 ALA 260 287 287 ALA ALA B . n 
B 1 261 GLU 261 288 288 GLU GLU B . n 
B 1 262 GLY 262 289 289 GLY GLY B . n 
B 1 263 LEU 263 290 290 LEU LEU B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NXL 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NXL 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 NXL 1   301 301 NXL LIG A . 
D 3 PO4 1   302 1   PO4 PO4 A . 
E 2 NXL 1   301 301 NXL LIG B . 
F 3 PO4 1   302 2   PO4 PO4 B . 
G 3 PO4 1   303 3   PO4 PO4 B . 
H 4 HOH 1   401 225 HOH HOH A . 
H 4 HOH 2   402 171 HOH HOH A . 
H 4 HOH 3   403 475 HOH HOH A . 
H 4 HOH 4   404 575 HOH HOH A . 
H 4 HOH 5   405 149 HOH HOH A . 
H 4 HOH 6   406 457 HOH HOH A . 
H 4 HOH 7   407 547 HOH HOH A . 
H 4 HOH 8   408 599 HOH HOH A . 
H 4 HOH 9   409 465 HOH HOH A . 
H 4 HOH 10  410 560 HOH HOH A . 
H 4 HOH 11  411 485 HOH HOH A . 
H 4 HOH 12  412 166 HOH HOH A . 
H 4 HOH 13  413 92  HOH HOH A . 
H 4 HOH 14  414 529 HOH HOH A . 
H 4 HOH 15  415 334 HOH HOH A . 
H 4 HOH 16  416 657 HOH HOH A . 
H 4 HOH 17  417 60  HOH HOH A . 
H 4 HOH 18  418 160 HOH HOH A . 
H 4 HOH 19  419 14  HOH HOH A . 
H 4 HOH 20  420 669 HOH HOH A . 
H 4 HOH 21  421 635 HOH HOH A . 
H 4 HOH 22  422 505 HOH HOH A . 
H 4 HOH 23  423 650 HOH HOH A . 
H 4 HOH 24  424 210 HOH HOH A . 
H 4 HOH 25  425 340 HOH HOH A . 
H 4 HOH 26  426 307 HOH HOH A . 
H 4 HOH 27  427 279 HOH HOH A . 
H 4 HOH 28  428 572 HOH HOH A . 
H 4 HOH 29  429 198 HOH HOH A . 
H 4 HOH 30  430 147 HOH HOH A . 
H 4 HOH 31  431 430 HOH HOH A . 
H 4 HOH 32  432 142 HOH HOH A . 
H 4 HOH 33  433 690 HOH HOH A . 
H 4 HOH 34  434 78  HOH HOH A . 
H 4 HOH 35  435 461 HOH HOH A . 
H 4 HOH 36  436 151 HOH HOH A . 
H 4 HOH 37  437 443 HOH HOH A . 
H 4 HOH 38  438 368 HOH HOH A . 
H 4 HOH 39  439 674 HOH HOH A . 
H 4 HOH 40  440 619 HOH HOH A . 
H 4 HOH 41  441 518 HOH HOH A . 
H 4 HOH 42  442 1   HOH HOH A . 
H 4 HOH 43  443 51  HOH HOH A . 
H 4 HOH 44  444 126 HOH HOH A . 
H 4 HOH 45  445 308 HOH HOH A . 
H 4 HOH 46  446 466 HOH HOH A . 
H 4 HOH 47  447 77  HOH HOH A . 
H 4 HOH 48  448 327 HOH HOH A . 
H 4 HOH 49  449 69  HOH HOH A . 
H 4 HOH 50  450 174 HOH HOH A . 
H 4 HOH 51  451 516 HOH HOH A . 
H 4 HOH 52  452 429 HOH HOH A . 
H 4 HOH 53  453 373 HOH HOH A . 
H 4 HOH 54  454 57  HOH HOH A . 
H 4 HOH 55  455 435 HOH HOH A . 
H 4 HOH 56  456 405 HOH HOH A . 
H 4 HOH 57  457 577 HOH HOH A . 
H 4 HOH 58  458 207 HOH HOH A . 
H 4 HOH 59  459 41  HOH HOH A . 
H 4 HOH 60  460 317 HOH HOH A . 
H 4 HOH 61  461 61  HOH HOH A . 
H 4 HOH 62  462 427 HOH HOH A . 
H 4 HOH 63  463 227 HOH HOH A . 
H 4 HOH 64  464 454 HOH HOH A . 
H 4 HOH 65  465 244 HOH HOH A . 
H 4 HOH 66  466 562 HOH HOH A . 
H 4 HOH 67  467 488 HOH HOH A . 
H 4 HOH 68  468 286 HOH HOH A . 
H 4 HOH 69  469 97  HOH HOH A . 
H 4 HOH 70  470 136 HOH HOH A . 
H 4 HOH 71  471 522 HOH HOH A . 
H 4 HOH 72  472 594 HOH HOH A . 
H 4 HOH 73  473 157 HOH HOH A . 
H 4 HOH 74  474 524 HOH HOH A . 
H 4 HOH 75  475 490 HOH HOH A . 
H 4 HOH 76  476 36  HOH HOH A . 
H 4 HOH 77  477 29  HOH HOH A . 
H 4 HOH 78  478 19  HOH HOH A . 
H 4 HOH 79  479 240 HOH HOH A . 
H 4 HOH 80  480 510 HOH HOH A . 
H 4 HOH 81  481 120 HOH HOH A . 
H 4 HOH 82  482 452 HOH HOH A . 
H 4 HOH 83  483 447 HOH HOH A . 
H 4 HOH 84  484 37  HOH HOH A . 
H 4 HOH 85  485 132 HOH HOH A . 
H 4 HOH 86  486 4   HOH HOH A . 
H 4 HOH 87  487 163 HOH HOH A . 
H 4 HOH 88  488 44  HOH HOH A . 
H 4 HOH 89  489 162 HOH HOH A . 
H 4 HOH 90  490 91  HOH HOH A . 
H 4 HOH 91  491 200 HOH HOH A . 
H 4 HOH 92  492 456 HOH HOH A . 
H 4 HOH 93  493 109 HOH HOH A . 
H 4 HOH 94  494 428 HOH HOH A . 
H 4 HOH 95  495 671 HOH HOH A . 
H 4 HOH 96  496 148 HOH HOH A . 
H 4 HOH 97  497 568 HOH HOH A . 
H 4 HOH 98  498 649 HOH HOH A . 
H 4 HOH 99  499 172 HOH HOH A . 
H 4 HOH 100 500 73  HOH HOH A . 
H 4 HOH 101 501 346 HOH HOH A . 
H 4 HOH 102 502 604 HOH HOH A . 
H 4 HOH 103 503 191 HOH HOH A . 
H 4 HOH 104 504 258 HOH HOH A . 
H 4 HOH 105 505 83  HOH HOH A . 
H 4 HOH 106 506 96  HOH HOH A . 
H 4 HOH 107 507 54  HOH HOH A . 
H 4 HOH 108 508 297 HOH HOH A . 
H 4 HOH 109 509 7   HOH HOH A . 
H 4 HOH 110 510 530 HOH HOH A . 
H 4 HOH 111 511 519 HOH HOH A . 
H 4 HOH 112 512 21  HOH HOH A . 
H 4 HOH 113 513 23  HOH HOH A . 
H 4 HOH 114 514 472 HOH HOH A . 
H 4 HOH 115 515 66  HOH HOH A . 
H 4 HOH 116 516 155 HOH HOH A . 
H 4 HOH 117 517 481 HOH HOH A . 
H 4 HOH 118 518 502 HOH HOH A . 
H 4 HOH 119 519 433 HOH HOH A . 
H 4 HOH 120 520 591 HOH HOH A . 
H 4 HOH 121 521 546 HOH HOH A . 
H 4 HOH 122 522 672 HOH HOH A . 
H 4 HOH 123 523 641 HOH HOH A . 
H 4 HOH 124 524 188 HOH HOH A . 
H 4 HOH 125 525 528 HOH HOH A . 
H 4 HOH 126 526 332 HOH HOH A . 
H 4 HOH 127 527 113 HOH HOH A . 
H 4 HOH 128 528 632 HOH HOH A . 
H 4 HOH 129 529 551 HOH HOH A . 
H 4 HOH 130 530 449 HOH HOH A . 
H 4 HOH 131 531 385 HOH HOH A . 
H 4 HOH 132 532 135 HOH HOH A . 
H 4 HOH 133 533 458 HOH HOH A . 
H 4 HOH 134 534 26  HOH HOH A . 
H 4 HOH 135 535 11  HOH HOH A . 
H 4 HOH 136 536 123 HOH HOH A . 
H 4 HOH 137 537 329 HOH HOH A . 
H 4 HOH 138 538 446 HOH HOH A . 
H 4 HOH 139 539 436 HOH HOH A . 
H 4 HOH 140 540 254 HOH HOH A . 
H 4 HOH 141 541 324 HOH HOH A . 
H 4 HOH 142 542 62  HOH HOH A . 
H 4 HOH 143 543 213 HOH HOH A . 
H 4 HOH 144 544 598 HOH HOH A . 
H 4 HOH 145 545 150 HOH HOH A . 
H 4 HOH 146 546 115 HOH HOH A . 
H 4 HOH 147 547 305 HOH HOH A . 
H 4 HOH 148 548 566 HOH HOH A . 
H 4 HOH 149 549 438 HOH HOH A . 
H 4 HOH 150 550 28  HOH HOH A . 
H 4 HOH 151 551 497 HOH HOH A . 
H 4 HOH 152 552 640 HOH HOH A . 
H 4 HOH 153 553 625 HOH HOH A . 
H 4 HOH 154 554 550 HOH HOH A . 
H 4 HOH 155 555 687 HOH HOH A . 
H 4 HOH 156 556 116 HOH HOH A . 
H 4 HOH 157 557 228 HOH HOH A . 
H 4 HOH 158 558 440 HOH HOH A . 
H 4 HOH 159 559 33  HOH HOH A . 
H 4 HOH 160 560 280 HOH HOH A . 
H 4 HOH 161 561 504 HOH HOH A . 
H 4 HOH 162 562 611 HOH HOH A . 
H 4 HOH 163 563 101 HOH HOH A . 
H 4 HOH 164 564 104 HOH HOH A . 
H 4 HOH 165 565 326 HOH HOH A . 
H 4 HOH 166 566 434 HOH HOH A . 
H 4 HOH 167 567 467 HOH HOH A . 
H 4 HOH 168 568 190 HOH HOH A . 
H 4 HOH 169 569 601 HOH HOH A . 
H 4 HOH 170 570 521 HOH HOH A . 
H 4 HOH 171 571 224 HOH HOH A . 
H 4 HOH 172 572 362 HOH HOH A . 
H 4 HOH 173 573 330 HOH HOH A . 
H 4 HOH 174 574 545 HOH HOH A . 
H 4 HOH 175 575 366 HOH HOH A . 
H 4 HOH 176 576 84  HOH HOH A . 
H 4 HOH 177 577 161 HOH HOH A . 
H 4 HOH 178 578 459 HOH HOH A . 
H 4 HOH 179 579 201 HOH HOH A . 
H 4 HOH 180 580 513 HOH HOH A . 
H 4 HOH 181 581 608 HOH HOH A . 
H 4 HOH 182 582 662 HOH HOH A . 
H 4 HOH 183 583 676 HOH HOH A . 
H 4 HOH 184 584 559 HOH HOH A . 
H 4 HOH 185 585 637 HOH HOH A . 
H 4 HOH 186 586 448 HOH HOH A . 
H 4 HOH 187 587 80  HOH HOH A . 
H 4 HOH 188 588 276 HOH HOH A . 
H 4 HOH 189 589 63  HOH HOH A . 
H 4 HOH 190 590 352 HOH HOH A . 
H 4 HOH 191 591 306 HOH HOH A . 
H 4 HOH 192 592 205 HOH HOH A . 
H 4 HOH 193 593 474 HOH HOH A . 
H 4 HOH 194 594 140 HOH HOH A . 
H 4 HOH 195 595 89  HOH HOH A . 
H 4 HOH 196 596 218 HOH HOH A . 
H 4 HOH 197 597 581 HOH HOH A . 
H 4 HOH 198 598 310 HOH HOH A . 
H 4 HOH 199 599 260 HOH HOH A . 
H 4 HOH 200 600 302 HOH HOH A . 
H 4 HOH 201 601 473 HOH HOH A . 
H 4 HOH 202 602 548 HOH HOH A . 
H 4 HOH 203 603 523 HOH HOH A . 
H 4 HOH 204 604 268 HOH HOH A . 
H 4 HOH 205 605 347 HOH HOH A . 
H 4 HOH 206 606 143 HOH HOH A . 
H 4 HOH 207 607 87  HOH HOH A . 
H 4 HOH 208 608 668 HOH HOH A . 
H 4 HOH 209 609 556 HOH HOH A . 
H 4 HOH 210 610 407 HOH HOH A . 
H 4 HOH 211 611 555 HOH HOH A . 
H 4 HOH 212 612 18  HOH HOH A . 
H 4 HOH 213 613 453 HOH HOH A . 
H 4 HOH 214 614 168 HOH HOH A . 
H 4 HOH 215 615 527 HOH HOH A . 
H 4 HOH 216 616 331 HOH HOH A . 
H 4 HOH 217 617 665 HOH HOH A . 
H 4 HOH 218 618 426 HOH HOH A . 
H 4 HOH 219 619 328 HOH HOH A . 
H 4 HOH 220 620 689 HOH HOH A . 
H 4 HOH 221 621 364 HOH HOH A . 
H 4 HOH 222 622 353 HOH HOH A . 
H 4 HOH 223 623 22  HOH HOH A . 
H 4 HOH 224 624 600 HOH HOH A . 
H 4 HOH 225 625 651 HOH HOH A . 
H 4 HOH 226 626 451 HOH HOH A . 
H 4 HOH 227 627 673 HOH HOH A . 
H 4 HOH 228 628 444 HOH HOH A . 
H 4 HOH 229 629 606 HOH HOH A . 
H 4 HOH 230 630 520 HOH HOH A . 
H 4 HOH 231 631 370 HOH HOH A . 
H 4 HOH 232 632 514 HOH HOH A . 
H 4 HOH 233 633 241 HOH HOH A . 
H 4 HOH 234 634 539 HOH HOH A . 
H 4 HOH 235 635 337 HOH HOH A . 
H 4 HOH 236 636 643 HOH HOH A . 
H 4 HOH 237 637 46  HOH HOH A . 
H 4 HOH 238 638 517 HOH HOH A . 
H 4 HOH 239 639 406 HOH HOH A . 
H 4 HOH 240 640 445 HOH HOH A . 
H 4 HOH 241 641 656 HOH HOH A . 
H 4 HOH 242 642 501 HOH HOH A . 
H 4 HOH 243 643 680 HOH HOH A . 
H 4 HOH 244 644 376 HOH HOH A . 
H 4 HOH 245 645 411 HOH HOH A . 
H 4 HOH 246 646 325 HOH HOH A . 
H 4 HOH 247 647 585 HOH HOH A . 
H 4 HOH 248 648 342 HOH HOH A . 
H 4 HOH 249 649 70  HOH HOH A . 
H 4 HOH 250 650 589 HOH HOH A . 
H 4 HOH 251 651 236 HOH HOH A . 
H 4 HOH 252 652 580 HOH HOH A . 
H 4 HOH 253 653 634 HOH HOH A . 
H 4 HOH 254 654 496 HOH HOH A . 
H 4 HOH 255 655 403 HOH HOH A . 
H 4 HOH 256 656 152 HOH HOH A . 
H 4 HOH 257 657 561 HOH HOH A . 
H 4 HOH 258 658 471 HOH HOH A . 
H 4 HOH 259 659 658 HOH HOH A . 
H 4 HOH 260 660 131 HOH HOH A . 
H 4 HOH 261 661 283 HOH HOH A . 
H 4 HOH 262 662 413 HOH HOH A . 
H 4 HOH 263 663 642 HOH HOH A . 
H 4 HOH 264 664 531 HOH HOH A . 
H 4 HOH 265 665 667 HOH HOH A . 
H 4 HOH 266 666 420 HOH HOH A . 
H 4 HOH 267 667 573 HOH HOH A . 
H 4 HOH 268 668 402 HOH HOH A . 
H 4 HOH 269 669 494 HOH HOH A . 
H 4 HOH 270 670 549 HOH HOH A . 
H 4 HOH 271 671 491 HOH HOH A . 
H 4 HOH 272 672 654 HOH HOH A . 
H 4 HOH 273 673 455 HOH HOH A . 
H 4 HOH 274 674 442 HOH HOH A . 
H 4 HOH 275 675 393 HOH HOH A . 
H 4 HOH 276 676 622 HOH HOH A . 
H 4 HOH 277 677 681 HOH HOH A . 
H 4 HOH 278 678 633 HOH HOH A . 
H 4 HOH 279 679 100 HOH HOH A . 
H 4 HOH 280 680 626 HOH HOH A . 
H 4 HOH 281 681 437 HOH HOH A . 
H 4 HOH 282 682 515 HOH HOH A . 
H 4 HOH 283 683 614 HOH HOH A . 
H 4 HOH 284 684 486 HOH HOH A . 
H 4 HOH 285 685 232 HOH HOH A . 
H 4 HOH 286 686 554 HOH HOH A . 
H 4 HOH 287 687 441 HOH HOH A . 
H 4 HOH 288 688 235 HOH HOH A . 
H 4 HOH 289 689 484 HOH HOH A . 
H 4 HOH 290 690 597 HOH HOH A . 
H 4 HOH 291 691 578 HOH HOH A . 
H 4 HOH 292 692 252 HOH HOH A . 
H 4 HOH 293 693 660 HOH HOH A . 
H 4 HOH 294 694 356 HOH HOH A . 
H 4 HOH 295 695 538 HOH HOH A . 
H 4 HOH 296 696 595 HOH HOH A . 
H 4 HOH 297 697 267 HOH HOH A . 
H 4 HOH 298 698 536 HOH HOH A . 
H 4 HOH 299 699 563 HOH HOH A . 
H 4 HOH 300 700 418 HOH HOH A . 
H 4 HOH 301 701 226 HOH HOH A . 
H 4 HOH 302 702 617 HOH HOH A . 
H 4 HOH 303 703 607 HOH HOH A . 
H 4 HOH 304 704 543 HOH HOH A . 
H 4 HOH 305 705 289 HOH HOH A . 
H 4 HOH 306 706 613 HOH HOH A . 
H 4 HOH 307 707 487 HOH HOH A . 
H 4 HOH 308 708 450 HOH HOH A . 
H 4 HOH 309 709 374 HOH HOH A . 
H 4 HOH 310 710 401 HOH HOH A . 
H 4 HOH 311 711 679 HOH HOH A . 
H 4 HOH 312 712 677 HOH HOH A . 
H 4 HOH 313 713 360 HOH HOH A . 
H 4 HOH 314 714 237 HOH HOH A . 
H 4 HOH 315 715 620 HOH HOH A . 
H 4 HOH 316 716 503 HOH HOH A . 
H 4 HOH 317 717 628 HOH HOH A . 
H 4 HOH 318 718 223 HOH HOH A . 
H 4 HOH 319 719 609 HOH HOH A . 
H 4 HOH 320 720 480 HOH HOH A . 
H 4 HOH 321 721 678 HOH HOH A . 
H 4 HOH 322 722 492 HOH HOH A . 
H 4 HOH 323 723 691 HOH HOH A . 
H 4 HOH 324 724 612 HOH HOH A . 
H 4 HOH 325 725 439 HOH HOH A . 
H 4 HOH 326 726 271 HOH HOH A . 
H 4 HOH 327 727 181 HOH HOH A . 
H 4 HOH 328 728 295 HOH HOH A . 
H 4 HOH 329 729 377 HOH HOH A . 
I 4 HOH 1   401 212 HOH HOH B . 
I 4 HOH 2   402 629 HOH HOH B . 
I 4 HOH 3   403 558 HOH HOH B . 
I 4 HOH 4   404 323 HOH HOH B . 
I 4 HOH 5   405 43  HOH HOH B . 
I 4 HOH 6   406 624 HOH HOH B . 
I 4 HOH 7   407 105 HOH HOH B . 
I 4 HOH 8   408 615 HOH HOH B . 
I 4 HOH 9   409 85  HOH HOH B . 
I 4 HOH 10  410 638 HOH HOH B . 
I 4 HOH 11  411 684 HOH HOH B . 
I 4 HOH 12  412 483 HOH HOH B . 
I 4 HOH 13  413 552 HOH HOH B . 
I 4 HOH 14  414 462 HOH HOH B . 
I 4 HOH 15  415 644 HOH HOH B . 
I 4 HOH 16  416 134 HOH HOH B . 
I 4 HOH 17  417 312 HOH HOH B . 
I 4 HOH 18  418 64  HOH HOH B . 
I 4 HOH 19  419 541 HOH HOH B . 
I 4 HOH 20  420 247 HOH HOH B . 
I 4 HOH 21  421 431 HOH HOH B . 
I 4 HOH 22  422 12  HOH HOH B . 
I 4 HOH 23  423 17  HOH HOH B . 
I 4 HOH 24  424 124 HOH HOH B . 
I 4 HOH 25  425 338 HOH HOH B . 
I 4 HOH 26  426 482 HOH HOH B . 
I 4 HOH 27  427 355 HOH HOH B . 
I 4 HOH 28  428 65  HOH HOH B . 
I 4 HOH 29  429 372 HOH HOH B . 
I 4 HOH 30  430 173 HOH HOH B . 
I 4 HOH 31  431 477 HOH HOH B . 
I 4 HOH 32  432 512 HOH HOH B . 
I 4 HOH 33  433 245 HOH HOH B . 
I 4 HOH 34  434 253 HOH HOH B . 
I 4 HOH 35  435 371 HOH HOH B . 
I 4 HOH 36  436 141 HOH HOH B . 
I 4 HOH 37  437 378 HOH HOH B . 
I 4 HOH 38  438 309 HOH HOH B . 
I 4 HOH 39  439 313 HOH HOH B . 
I 4 HOH 40  440 246 HOH HOH B . 
I 4 HOH 41  441 316 HOH HOH B . 
I 4 HOH 42  442 52  HOH HOH B . 
I 4 HOH 43  443 71  HOH HOH B . 
I 4 HOH 44  444 2   HOH HOH B . 
I 4 HOH 45  445 154 HOH HOH B . 
I 4 HOH 46  446 25  HOH HOH B . 
I 4 HOH 47  447 369 HOH HOH B . 
I 4 HOH 48  448 257 HOH HOH B . 
I 4 HOH 49  449 652 HOH HOH B . 
I 4 HOH 50  450 666 HOH HOH B . 
I 4 HOH 51  451 110 HOH HOH B . 
I 4 HOH 52  452 8   HOH HOH B . 
I 4 HOH 53  453 605 HOH HOH B . 
I 4 HOH 54  454 5   HOH HOH B . 
I 4 HOH 55  455 99  HOH HOH B . 
I 4 HOH 56  456 618 HOH HOH B . 
I 4 HOH 57  457 489 HOH HOH B . 
I 4 HOH 58  458 179 HOH HOH B . 
I 4 HOH 59  459 571 HOH HOH B . 
I 4 HOH 60  460 106 HOH HOH B . 
I 4 HOH 61  461 590 HOH HOH B . 
I 4 HOH 62  462 202 HOH HOH B . 
I 4 HOH 63  463 137 HOH HOH B . 
I 4 HOH 64  464 564 HOH HOH B . 
I 4 HOH 65  465 623 HOH HOH B . 
I 4 HOH 66  466 47  HOH HOH B . 
I 4 HOH 67  467 395 HOH HOH B . 
I 4 HOH 68  468 164 HOH HOH B . 
I 4 HOH 69  469 133 HOH HOH B . 
I 4 HOH 70  470 269 HOH HOH B . 
I 4 HOH 71  471 42  HOH HOH B . 
I 4 HOH 72  472 204 HOH HOH B . 
I 4 HOH 73  473 298 HOH HOH B . 
I 4 HOH 74  474 187 HOH HOH B . 
I 4 HOH 75  475 9   HOH HOH B . 
I 4 HOH 76  476 34  HOH HOH B . 
I 4 HOH 77  477 663 HOH HOH B . 
I 4 HOH 78  478 31  HOH HOH B . 
I 4 HOH 79  479 464 HOH HOH B . 
I 4 HOH 80  480 38  HOH HOH B . 
I 4 HOH 81  481 363 HOH HOH B . 
I 4 HOH 82  482 367 HOH HOH B . 
I 4 HOH 83  483 76  HOH HOH B . 
I 4 HOH 84  484 375 HOH HOH B . 
I 4 HOH 85  485 59  HOH HOH B . 
I 4 HOH 86  486 72  HOH HOH B . 
I 4 HOH 87  487 582 HOH HOH B . 
I 4 HOH 88  488 380 HOH HOH B . 
I 4 HOH 89  489 194 HOH HOH B . 
I 4 HOH 90  490 178 HOH HOH B . 
I 4 HOH 91  491 256 HOH HOH B . 
I 4 HOH 92  492 15  HOH HOH B . 
I 4 HOH 93  493 102 HOH HOH B . 
I 4 HOH 94  494 189 HOH HOH B . 
I 4 HOH 95  495 55  HOH HOH B . 
I 4 HOH 96  496 195 HOH HOH B . 
I 4 HOH 97  497 167 HOH HOH B . 
I 4 HOH 98  498 322 HOH HOH B . 
I 4 HOH 99  499 130 HOH HOH B . 
I 4 HOH 100 500 27  HOH HOH B . 
I 4 HOH 101 501 424 HOH HOH B . 
I 4 HOH 102 502 6   HOH HOH B . 
I 4 HOH 103 503 350 HOH HOH B . 
I 4 HOH 104 504 40  HOH HOH B . 
I 4 HOH 105 505 192 HOH HOH B . 
I 4 HOH 106 506 296 HOH HOH B . 
I 4 HOH 107 507 153 HOH HOH B . 
I 4 HOH 108 508 158 HOH HOH B . 
I 4 HOH 109 509 122 HOH HOH B . 
I 4 HOH 110 510 107 HOH HOH B . 
I 4 HOH 111 511 270 HOH HOH B . 
I 4 HOH 112 512 50  HOH HOH B . 
I 4 HOH 113 513 56  HOH HOH B . 
I 4 HOH 114 514 144 HOH HOH B . 
I 4 HOH 115 515 647 HOH HOH B . 
I 4 HOH 116 516 230 HOH HOH B . 
I 4 HOH 117 517 682 HOH HOH B . 
I 4 HOH 118 518 45  HOH HOH B . 
I 4 HOH 119 519 336 HOH HOH B . 
I 4 HOH 120 520 583 HOH HOH B . 
I 4 HOH 121 521 499 HOH HOH B . 
I 4 HOH 122 522 661 HOH HOH B . 
I 4 HOH 123 523 108 HOH HOH B . 
I 4 HOH 124 524 432 HOH HOH B . 
I 4 HOH 125 525 354 HOH HOH B . 
I 4 HOH 126 526 112 HOH HOH B . 
I 4 HOH 127 527 186 HOH HOH B . 
I 4 HOH 128 528 291 HOH HOH B . 
I 4 HOH 129 529 93  HOH HOH B . 
I 4 HOH 130 530 53  HOH HOH B . 
I 4 HOH 131 531 664 HOH HOH B . 
I 4 HOH 132 532 311 HOH HOH B . 
I 4 HOH 133 533 243 HOH HOH B . 
I 4 HOH 134 534 231 HOH HOH B . 
I 4 HOH 135 535 321 HOH HOH B . 
I 4 HOH 136 536 13  HOH HOH B . 
I 4 HOH 137 537 75  HOH HOH B . 
I 4 HOH 138 538 576 HOH HOH B . 
I 4 HOH 139 539 222 HOH HOH B . 
I 4 HOH 140 540 193 HOH HOH B . 
I 4 HOH 141 541 263 HOH HOH B . 
I 4 HOH 142 542 175 HOH HOH B . 
I 4 HOH 143 543 95  HOH HOH B . 
I 4 HOH 144 544 98  HOH HOH B . 
I 4 HOH 145 545 208 HOH HOH B . 
I 4 HOH 146 546 129 HOH HOH B . 
I 4 HOH 147 547 32  HOH HOH B . 
I 4 HOH 148 548 655 HOH HOH B . 
I 4 HOH 149 549 82  HOH HOH B . 
I 4 HOH 150 550 146 HOH HOH B . 
I 4 HOH 151 551 648 HOH HOH B . 
I 4 HOH 152 552 249 HOH HOH B . 
I 4 HOH 153 553 156 HOH HOH B . 
I 4 HOH 154 554 182 HOH HOH B . 
I 4 HOH 155 555 293 HOH HOH B . 
I 4 HOH 156 556 250 HOH HOH B . 
I 4 HOH 157 557 509 HOH HOH B . 
I 4 HOH 158 558 314 HOH HOH B . 
I 4 HOH 159 559 242 HOH HOH B . 
I 4 HOH 160 560 169 HOH HOH B . 
I 4 HOH 161 561 460 HOH HOH B . 
I 4 HOH 162 562 88  HOH HOH B . 
I 4 HOH 163 563 20  HOH HOH B . 
I 4 HOH 164 564 81  HOH HOH B . 
I 4 HOH 165 565 419 HOH HOH B . 
I 4 HOH 166 566 3   HOH HOH B . 
I 4 HOH 167 567 636 HOH HOH B . 
I 4 HOH 168 568 303 HOH HOH B . 
I 4 HOH 169 569 199 HOH HOH B . 
I 4 HOH 170 570 121 HOH HOH B . 
I 4 HOH 171 571 685 HOH HOH B . 
I 4 HOH 172 572 219 HOH HOH B . 
I 4 HOH 173 573 48  HOH HOH B . 
I 4 HOH 174 574 344 HOH HOH B . 
I 4 HOH 175 575 196 HOH HOH B . 
I 4 HOH 176 576 292 HOH HOH B . 
I 4 HOH 177 577 203 HOH HOH B . 
I 4 HOH 178 578 197 HOH HOH B . 
I 4 HOH 179 579 30  HOH HOH B . 
I 4 HOH 180 580 35  HOH HOH B . 
I 4 HOH 181 581 570 HOH HOH B . 
I 4 HOH 182 582 24  HOH HOH B . 
I 4 HOH 183 583 266 HOH HOH B . 
I 4 HOH 184 584 384 HOH HOH B . 
I 4 HOH 185 585 86  HOH HOH B . 
I 4 HOH 186 586 383 HOH HOH B . 
I 4 HOH 187 587 315 HOH HOH B . 
I 4 HOH 188 588 74  HOH HOH B . 
I 4 HOH 189 589 184 HOH HOH B . 
I 4 HOH 190 590 183 HOH HOH B . 
I 4 HOH 191 591 10  HOH HOH B . 
I 4 HOH 192 592 125 HOH HOH B . 
I 4 HOH 193 593 58  HOH HOH B . 
I 4 HOH 194 594 281 HOH HOH B . 
I 4 HOH 195 595 117 HOH HOH B . 
I 4 HOH 196 596 220 HOH HOH B . 
I 4 HOH 197 597 251 HOH HOH B . 
I 4 HOH 198 598 79  HOH HOH B . 
I 4 HOH 199 599 39  HOH HOH B . 
I 4 HOH 200 600 540 HOH HOH B . 
I 4 HOH 201 601 239 HOH HOH B . 
I 4 HOH 202 602 233 HOH HOH B . 
I 4 HOH 203 603 145 HOH HOH B . 
I 4 HOH 204 604 94  HOH HOH B . 
I 4 HOH 205 605 351 HOH HOH B . 
I 4 HOH 206 606 209 HOH HOH B . 
I 4 HOH 207 607 284 HOH HOH B . 
I 4 HOH 208 608 508 HOH HOH B . 
I 4 HOH 209 609 653 HOH HOH B . 
I 4 HOH 210 610 511 HOH HOH B . 
I 4 HOH 211 611 278 HOH HOH B . 
I 4 HOH 212 612 596 HOH HOH B . 
I 4 HOH 213 613 493 HOH HOH B . 
I 4 HOH 214 614 422 HOH HOH B . 
I 4 HOH 215 615 67  HOH HOH B . 
I 4 HOH 216 616 90  HOH HOH B . 
I 4 HOH 217 617 586 HOH HOH B . 
I 4 HOH 218 618 542 HOH HOH B . 
I 4 HOH 219 619 553 HOH HOH B . 
I 4 HOH 220 620 215 HOH HOH B . 
I 4 HOH 221 621 255 HOH HOH B . 
I 4 HOH 222 622 537 HOH HOH B . 
I 4 HOH 223 623 686 HOH HOH B . 
I 4 HOH 224 624 294 HOH HOH B . 
I 4 HOH 225 625 138 HOH HOH B . 
I 4 HOH 226 626 111 HOH HOH B . 
I 4 HOH 227 627 498 HOH HOH B . 
I 4 HOH 228 628 526 HOH HOH B . 
I 4 HOH 229 629 414 HOH HOH B . 
I 4 HOH 230 630 567 HOH HOH B . 
I 4 HOH 231 631 463 HOH HOH B . 
I 4 HOH 232 632 631 HOH HOH B . 
I 4 HOH 233 633 565 HOH HOH B . 
I 4 HOH 234 634 349 HOH HOH B . 
I 4 HOH 235 635 318 HOH HOH B . 
I 4 HOH 236 636 603 HOH HOH B . 
I 4 HOH 237 637 114 HOH HOH B . 
I 4 HOH 238 638 359 HOH HOH B . 
I 4 HOH 239 639 381 HOH HOH B . 
I 4 HOH 240 640 621 HOH HOH B . 
I 4 HOH 241 641 335 HOH HOH B . 
I 4 HOH 242 642 357 HOH HOH B . 
I 4 HOH 243 643 579 HOH HOH B . 
I 4 HOH 244 644 532 HOH HOH B . 
I 4 HOH 245 645 119 HOH HOH B . 
I 4 HOH 246 646 675 HOH HOH B . 
I 4 HOH 247 647 229 HOH HOH B . 
I 4 HOH 248 648 506 HOH HOH B . 
I 4 HOH 249 649 299 HOH HOH B . 
I 4 HOH 250 650 610 HOH HOH B . 
I 4 HOH 251 651 587 HOH HOH B . 
I 4 HOH 252 652 688 HOH HOH B . 
I 4 HOH 253 653 391 HOH HOH B . 
I 4 HOH 254 654 400 HOH HOH B . 
I 4 HOH 255 655 574 HOH HOH B . 
I 4 HOH 256 656 333 HOH HOH B . 
I 4 HOH 257 657 379 HOH HOH B . 
I 4 HOH 258 658 206 HOH HOH B . 
I 4 HOH 259 659 238 HOH HOH B . 
I 4 HOH 260 660 290 HOH HOH B . 
I 4 HOH 261 661 410 HOH HOH B . 
I 4 HOH 262 662 683 HOH HOH B . 
I 4 HOH 263 663 217 HOH HOH B . 
I 4 HOH 264 664 300 HOH HOH B . 
I 4 HOH 265 665 630 HOH HOH B . 
I 4 HOH 266 666 592 HOH HOH B . 
I 4 HOH 267 667 264 HOH HOH B . 
I 4 HOH 268 668 423 HOH HOH B . 
I 4 HOH 269 669 221 HOH HOH B . 
I 4 HOH 270 670 396 HOH HOH B . 
I 4 HOH 271 671 388 HOH HOH B . 
I 4 HOH 272 672 544 HOH HOH B . 
I 4 HOH 273 673 588 HOH HOH B . 
I 4 HOH 274 674 602 HOH HOH B . 
I 4 HOH 275 675 248 HOH HOH B . 
I 4 HOH 276 676 415 HOH HOH B . 
I 4 HOH 277 677 645 HOH HOH B . 
I 4 HOH 278 678 593 HOH HOH B . 
I 4 HOH 279 679 185 HOH HOH B . 
I 4 HOH 280 680 557 HOH HOH B . 
I 4 HOH 281 681 234 HOH HOH B . 
I 4 HOH 282 682 139 HOH HOH B . 
I 4 HOH 283 683 127 HOH HOH B . 
I 4 HOH 284 684 159 HOH HOH B . 
I 4 HOH 285 685 320 HOH HOH B . 
I 4 HOH 286 686 469 HOH HOH B . 
I 4 HOH 287 687 365 HOH HOH B . 
I 4 HOH 288 688 476 HOH HOH B . 
I 4 HOH 289 689 627 HOH HOH B . 
I 4 HOH 290 690 470 HOH HOH B . 
I 4 HOH 291 691 392 HOH HOH B . 
I 4 HOH 292 692 262 HOH HOH B . 
I 4 HOH 293 693 16  HOH HOH B . 
I 4 HOH 294 694 421 HOH HOH B . 
I 4 HOH 295 695 525 HOH HOH B . 
I 4 HOH 296 696 165 HOH HOH B . 
I 4 HOH 297 697 177 HOH HOH B . 
I 4 HOH 298 698 535 HOH HOH B . 
I 4 HOH 299 699 659 HOH HOH B . 
I 4 HOH 300 700 259 HOH HOH B . 
I 4 HOH 301 701 646 HOH HOH B . 
I 4 HOH 302 702 261 HOH HOH B . 
I 4 HOH 303 703 288 HOH HOH B . 
I 4 HOH 304 704 398 HOH HOH B . 
I 4 HOH 305 705 416 HOH HOH B . 
I 4 HOH 306 706 394 HOH HOH B . 
I 4 HOH 307 707 128 HOH HOH B . 
I 4 HOH 308 708 345 HOH HOH B . 
I 4 HOH 309 709 468 HOH HOH B . 
I 4 HOH 310 710 404 HOH HOH B . 
I 4 HOH 311 711 273 HOH HOH B . 
I 4 HOH 312 712 478 HOH HOH B . 
I 4 HOH 313 713 479 HOH HOH B . 
I 4 HOH 314 714 214 HOH HOH B . 
I 4 HOH 315 715 584 HOH HOH B . 
I 4 HOH 316 716 397 HOH HOH B . 
I 4 HOH 317 717 103 HOH HOH B . 
I 4 HOH 318 718 417 HOH HOH B . 
I 4 HOH 319 719 639 HOH HOH B . 
I 4 HOH 320 720 358 HOH HOH B . 
I 4 HOH 321 721 386 HOH HOH B . 
I 4 HOH 322 722 180 HOH HOH B . 
I 4 HOH 323 723 287 HOH HOH B . 
I 4 HOH 324 724 49  HOH HOH B . 
I 4 HOH 325 725 265 HOH HOH B . 
I 4 HOH 326 726 670 HOH HOH B . 
I 4 HOH 327 727 399 HOH HOH B . 
I 4 HOH 328 728 274 HOH HOH B . 
I 4 HOH 329 729 569 HOH HOH B . 
I 4 HOH 330 730 211 HOH HOH B . 
I 4 HOH 331 731 272 HOH HOH B . 
I 4 HOH 332 732 216 HOH HOH B . 
I 4 HOH 333 733 339 HOH HOH B . 
I 4 HOH 334 734 507 HOH HOH B . 
I 4 HOH 335 735 348 HOH HOH B . 
I 4 HOH 336 736 382 HOH HOH B . 
I 4 HOH 337 737 408 HOH HOH B . 
I 4 HOH 338 738 534 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 ? 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XSCALE      ? ? ? .           ? 2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .           ? 3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .           ? 4 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? .           ? 5 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.98 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9OR7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.290 
_cell.length_a_esd                 ? 
_cell.length_b                     106.820 
_cell.length_b_esd                 ? 
_cell.length_c                     47.980 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9OR7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9OR7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.04 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.58 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.9 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.4 M potassium phosphate pH 7.9' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         RIGAKU 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2025-05-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-E+' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9OR7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.5 
_reflns.d_resolution_low                               46.94 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     137873 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.51 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.84 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.042 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.5 
_reflns_shell.d_res_low                                     1.6 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           6.62 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             24033 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.44 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.951 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          97 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.233 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9OR7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.50 
_refine.ls_d_res_low                             46.94 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     70630 
_refine.ls_number_reflns_R_free                  3530 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.19 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1887 
_refine.ls_R_factor_R_free                       0.2203 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1871 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.40 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.50 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.16 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.50 
_refine_hist.d_res_low                        46.94 
_refine_hist.number_atoms_solvent             667 
_refine_hist.number_atoms_total               4630 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3948 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         15 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006 ? 4144 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 0.979 ? 5662 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 7.138 ? 613  ? f_dihedral_angle_d ? ? ? 
'X-RAY DIFFRACTION' ? 0.085 ? 663  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.009 ? 753  ? f_plane_restr      ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.50 1.52  . . 138 2627 98.00  . . . . 0.2037 . . . . . . . . . . . . . . . 0.2505 
'X-RAY DIFFRACTION' 1.52 1.54  . . 142 2692 99.00  . . . . 0.1871 . . . . . . . . . . . . . . . 0.2483 
'X-RAY DIFFRACTION' 1.54 1.57  . . 138 2625 99.00  . . . . 0.1829 . . . . . . . . . . . . . . . 0.2307 
'X-RAY DIFFRACTION' 1.57 1.59  . . 140 2664 99.00  . . . . 0.2019 . . . . . . . . . . . . . . . 0.2170 
'X-RAY DIFFRACTION' 1.59 1.62  . . 142 2689 99.00  . . . . 0.2039 . . . . . . . . . . . . . . . 0.2627 
'X-RAY DIFFRACTION' 1.62 1.64  . . 139 2650 99.00  . . . . 0.2344 . . . . . . . . . . . . . . . 0.3073 
'X-RAY DIFFRACTION' 1.64 1.67  . . 143 2716 99.00  . . . . 0.2356 . . . . . . . . . . . . . . . 0.2463 
'X-RAY DIFFRACTION' 1.67 1.71  . . 141 2664 100.00 . . . . 0.2019 . . . . . . . . . . . . . . . 0.2352 
'X-RAY DIFFRACTION' 1.71 1.74  . . 142 2707 100.00 . . . . 0.1864 . . . . . . . . . . . . . . . 0.2395 
'X-RAY DIFFRACTION' 1.74 1.78  . . 142 2694 100.00 . . . . 0.1690 . . . . . . . . . . . . . . . 0.2399 
'X-RAY DIFFRACTION' 1.78 1.82  . . 142 2699 100.00 . . . . 0.1584 . . . . . . . . . . . . . . . 0.2218 
'X-RAY DIFFRACTION' 1.82 1.87  . . 141 2684 100.00 . . . . 0.1628 . . . . . . . . . . . . . . . 0.1958 
'X-RAY DIFFRACTION' 1.87 1.92  . . 135 2571 95.00  . . . . 0.2999 . . . . . . . . . . . . . . . 0.3243 
'X-RAY DIFFRACTION' 1.92 1.97  . . 142 2691 99.00  . . . . 0.2665 . . . . . . . . . . . . . . . 0.3200 
'X-RAY DIFFRACTION' 1.97 2.04  . . 141 2689 100.00 . . . . 0.1715 . . . . . . . . . . . . . . . 0.2140 
'X-RAY DIFFRACTION' 2.04 2.11  . . 141 2689 100.00 . . . . 0.1640 . . . . . . . . . . . . . . . 0.2088 
'X-RAY DIFFRACTION' 2.11 2.19  . . 144 2723 100.00 . . . . 0.1594 . . . . . . . . . . . . . . . 0.1898 
'X-RAY DIFFRACTION' 2.19 2.29  . . 136 2597 96.00  . . . . 0.2976 . . . . . . . . . . . . . . . 0.3614 
'X-RAY DIFFRACTION' 2.29 2.41  . . 142 2703 100.00 . . . . 0.1698 . . . . . . . . . . . . . . . 0.2155 
'X-RAY DIFFRACTION' 2.41 2.56  . . 142 2704 100.00 . . . . 0.1832 . . . . . . . . . . . . . . . 0.2096 
'X-RAY DIFFRACTION' 2.56 2.76  . . 141 2695 100.00 . . . . 0.1631 . . . . . . . . . . . . . . . 0.2214 
'X-RAY DIFFRACTION' 2.76 3.04  . . 145 2742 100.00 . . . . 0.1612 . . . . . . . . . . . . . . . 0.1819 
'X-RAY DIFFRACTION' 3.04 3.48  . . 143 2721 100.00 . . . . 0.1528 . . . . . . . . . . . . . . . 0.1432 
'X-RAY DIFFRACTION' 3.48 4.38  . . 143 2712 100.00 . . . . 0.1501 . . . . . . . . . . . . . . . 0.1655 
'X-RAY DIFFRACTION' 4.38 46.94 . . 145 2752 100.00 . . . . 0.1447 . . . . . . . . . . . . . . . 0.1589 
# 
_struct.entry_id                     9OR7 
_struct.title                        'X-ray diffraction structure of CTX-M-14 beta-lactamase soaked with avibactam' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9OR7 
_struct_keywords.text            'hydrolase, enzyme, beta-lactamase, inhibitor, complex' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9L5C7_ECOLX 
_struct_ref.pdbx_db_accession          Q9L5C7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_struct_ref.pdbx_align_begin           29 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9OR7 A 1 ? 263 ? Q9L5C7 29 ? 291 ? 25 290 
2 1 9OR7 B 1 ? 263 ? Q9L5C7 29 ? 291 ? 25 290 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA monomeric 1 
2 author_and_software_defined_assembly PISA monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,H   
2 1 B,E,F,G,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 4   ? GLY A 17  ? ALA A 28  GLY A 41  1 ? 14 
HELX_P HELX_P2  AA2 CYS A 44  ? THR A 46  ? CYS A 69  THR A 71  5 ? 3  
HELX_P HELX_P3  AA3 SER A 47  ? SER A 59  ? SER A 72  SER A 84  1 ? 13 
HELX_P HELX_P4  AA4 GLN A 64  ? ASN A 67  ? GLN A 89  ASN A 92  5 ? 4  
HELX_P HELX_P5  AA5 LYS A 73  ? LEU A 77  ? LYS A 98  LEU A 102 5 ? 5  
HELX_P HELX_P6  AA6 ILE A 83  ? HIS A 87  ? ILE A 108 HIS A 112 5 ? 5  
HELX_P HELX_P7  AA7 LEU A 94  ? TYR A 104 ? LEU A 119 TYR A 129 1 ? 11 
HELX_P HELX_P8  AA8 ASP A 106 ? LEU A 117 ? ASP A 131 LEU A 142 1 ? 12 
HELX_P HELX_P9  AA9 GLY A 119 ? ILE A 130 ? GLY A 144 ILE A 155 1 ? 12 
HELX_P HELX_P10 AB1 PRO A 142 ? THR A 146 ? PRO A 167 THR A 171 5 ? 5  
HELX_P HELX_P11 AB2 THR A 157 ? LEU A 170 ? THR A 182 LEU A 195 1 ? 14 
HELX_P HELX_P12 AB3 GLY A 175 ? GLY A 188 ? GLY A 200 GLY A 213 1 ? 14 
HELX_P HELX_P13 AB4 SER A 195 ? LEU A 200 ? SER A 220 LEU A 225 5 ? 6  
HELX_P HELX_P14 AB5 ARG A 248 ? GLY A 262 ? ARG A 275 GLY A 289 1 ? 15 
HELX_P HELX_P15 AB6 SER B 3   ? GLY B 17  ? SER B 27  GLY B 41  1 ? 15 
HELX_P HELX_P16 AB7 CYS B 44  ? THR B 46  ? CYS B 69  THR B 71  5 ? 3  
HELX_P HELX_P17 AB8 SER B 47  ? GLU B 60  ? SER B 72  GLU B 85  1 ? 14 
HELX_P HELX_P18 AB9 GLN B 64  ? ASN B 67  ? GLN B 89  ASN B 92  5 ? 4  
HELX_P HELX_P19 AC1 LYS B 73  ? LEU B 77  ? LYS B 98  LEU B 102 5 ? 5  
HELX_P HELX_P20 AC2 ILE B 83  ? VAL B 88  ? ILE B 108 VAL B 113 5 ? 6  
HELX_P HELX_P21 AC3 LEU B 94  ? TYR B 104 ? LEU B 119 TYR B 129 1 ? 11 
HELX_P HELX_P22 AC4 ASP B 106 ? LEU B 117 ? ASP B 131 LEU B 142 1 ? 12 
HELX_P HELX_P23 AC5 GLY B 119 ? ILE B 130 ? GLY B 144 ILE B 155 1 ? 12 
HELX_P HELX_P24 AC6 PRO B 142 ? THR B 146 ? PRO B 167 THR B 171 5 ? 5  
HELX_P HELX_P25 AC7 THR B 157 ? LEU B 170 ? THR B 182 LEU B 195 1 ? 14 
HELX_P HELX_P26 AC8 GLY B 175 ? GLY B 188 ? GLY B 200 GLY B 213 1 ? 14 
HELX_P HELX_P27 AC9 SER B 195 ? LEU B 200 ? SER B 220 LEU B 225 5 ? 6  
HELX_P HELX_P28 AD1 ARG B 248 ? GLY B 262 ? ARG B 275 GLY B 289 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A SER 45 OG ? ? ? 1_555 C NXL . CAN ? ? A SER 70 A NXL 301 1_555 ? ? ? ? ? ? ? 1.382 ? ? 
covale2 covale none ? B SER 45 OG ? ? ? 1_555 E NXL . CAN ? ? B SER 70 B NXL 301 1_555 ? ? ? ? ? ? ? 1.381 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NXL C . ? SER A 45 ? NXL A 301 ? 1_555 SER A 70 ? 1_555 CAN OG SER 2 NXL None 'Covalent chemical modification' 
2 NXL E . ? SER B 45 ? NXL B 301 ? 1_555 SER B 70 ? 1_555 CAN OG SER 2 NXL None 'Covalent chemical modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 141 A . ? GLU 166 A PRO 142 A ? PRO 167 A 1 5.13 
2 GLU 141 B . ? GLU 166 B PRO 142 B ? PRO 167 B 1 8.40 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 32  ? TYR A 35  ? GLN A 56  TYR A 60  
AA1 2 ARG A 19  ? ASP A 26  ? ARG A 43  ASP A 50  
AA1 3 LEU A 232 ? THR A 239 ? LEU A 259 THR A 266 
AA1 4 THR A 217 ? TRP A 225 ? THR A 243 TRP A 251 
AA1 5 THR A 205 ? GLY A 213 ? THR A 230 GLY A 238 
AA2 1 PHE A 41  ? PRO A 42  ? PHE A 66  PRO A 67  
AA2 2 THR A 155 ? THR A 156 ? THR A 180 THR A 181 
AA3 1 PRO A 69  ? ILE A 72  ? PRO A 94  ILE A 97  
AA3 2 GLY A 90  ? THR A 93  ? GLY A 115 THR A 118 
AA4 1 GLN B 32  ? TYR B 35  ? GLN B 56  TYR B 60  
AA4 2 ARG B 19  ? ASP B 26  ? ARG B 43  ASP B 50  
AA4 3 LEU B 232 ? THR B 239 ? LEU B 259 THR B 266 
AA4 4 THR B 217 ? TRP B 225 ? THR B 243 TRP B 251 
AA4 5 THR B 205 ? GLY B 213 ? THR B 230 GLY B 238 
AA5 1 PHE B 41  ? PRO B 42  ? PHE B 66  PRO B 67  
AA5 2 THR B 155 ? THR B 156 ? THR B 180 THR B 181 
AA6 1 PRO B 69  ? ILE B 72  ? PRO B 94  ILE B 97  
AA6 2 GLY B 90  ? THR B 93  ? GLY B 115 THR B 118 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 33  ? O VAL A 57  N LEU A 24  ? N LEU A 48  
AA1 2 3 N ARG A 19  ? N ARG A 43  O THR A 239 ? O THR A 266 
AA1 3 4 O LEU A 232 ? O LEU A 259 N ILE A 224 ? N ILE A 250 
AA1 4 5 O TRP A 225 ? O TRP A 251 N THR A 205 ? N THR A 230 
AA2 1 2 N PHE A 41  ? N PHE A 66  O THR A 156 ? O THR A 181 
AA3 1 2 N ILE A 72  ? N ILE A 97  O GLY A 90  ? O GLY A 115 
AA4 1 2 O VAL B 33  ? O VAL B 57  N LEU B 24  ? N LEU B 48  
AA4 2 3 N GLY B 21  ? N GLY B 45  O TYR B 237 ? O TYR B 264 
AA4 3 4 O LEU B 232 ? O LEU B 259 N ILE B 224 ? N ILE B 250 
AA4 4 5 O TRP B 225 ? O TRP B 251 N THR B 205 ? N THR B 230 
AA5 1 2 N PHE B 41  ? N PHE B 66  O THR B 156 ? O THR B 181 
AA6 1 2 N ILE B 72  ? N ILE B 97  O GLY B 90  ? O GLY B 115 
# 
_pdbx_entry_details.entry_id                   9OR7 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 69  ? ? 49.92   -135.14 
2 1 VAL A 103 ? ? -116.55 -136.35 
3 1 SER A 220 ? ? -106.26 -123.53 
4 1 CYS B 69  ? ? 49.38   -136.23 
5 1 VAL B 103 ? ? -119.87 -132.72 
6 1 ASN B 106 ? ? -152.29 62.49   
7 1 SER B 220 ? ? -105.88 -128.69 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 729 ? 6.41 . 
2 1 O ? B HOH 738 ? 5.85 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLN 25 ? A GLN 1 
2 1 Y 1 A THR 26 ? A THR 2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NXL OAC  O N N 250 
NXL CAN  C N N 251 
NXL N    N N N 252 
NXL CAJ  C N N 253 
NXL CA   C N S 254 
NXL C    C N N 255 
NXL O    O N N 256 
NXL NAA  N N N 257 
NXL CB   C N N 258 
NXL CAH  C N N 259 
NXL CAO  C N R 260 
NXL NAK  N N N 261 
NXL OAL  O N N 262 
NXL SAR  S N N 263 
NXL OAD  O N N 264 
NXL OAE  O N N 265 
NXL OAG  O N N 266 
NXL H1   H N N 267 
NXL H2   H N N 268 
NXL H3   H N N 269 
NXL H4   H N N 270 
NXL H5   H N N 271 
NXL H6   H N N 272 
NXL H7   H N N 273 
NXL H8   H N N 274 
NXL H9   H N N 275 
NXL H10  H N N 276 
NXL H11  H N N 277 
NXL H12  H N N 278 
NXL H13  H N N 279 
PHE N    N N N 280 
PHE CA   C N S 281 
PHE C    C N N 282 
PHE O    O N N 283 
PHE CB   C N N 284 
PHE CG   C Y N 285 
PHE CD1  C Y N 286 
PHE CD2  C Y N 287 
PHE CE1  C Y N 288 
PHE CE2  C Y N 289 
PHE CZ   C Y N 290 
PHE OXT  O N N 291 
PHE H    H N N 292 
PHE H2   H N N 293 
PHE HA   H N N 294 
PHE HB2  H N N 295 
PHE HB3  H N N 296 
PHE HD1  H N N 297 
PHE HD2  H N N 298 
PHE HE1  H N N 299 
PHE HE2  H N N 300 
PHE HZ   H N N 301 
PHE HXT  H N N 302 
PO4 P    P N N 303 
PO4 O1   O N N 304 
PO4 O2   O N N 305 
PO4 O3   O N N 306 
PO4 O4   O N N 307 
PRO N    N N N 308 
PRO CA   C N S 309 
PRO C    C N N 310 
PRO O    O N N 311 
PRO CB   C N N 312 
PRO CG   C N N 313 
PRO CD   C N N 314 
PRO OXT  O N N 315 
PRO H    H N N 316 
PRO HA   H N N 317 
PRO HB2  H N N 318 
PRO HB3  H N N 319 
PRO HG2  H N N 320 
PRO HG3  H N N 321 
PRO HD2  H N N 322 
PRO HD3  H N N 323 
PRO HXT  H N N 324 
SER N    N N N 325 
SER CA   C N S 326 
SER C    C N N 327 
SER O    O N N 328 
SER CB   C N N 329 
SER OG   O N N 330 
SER OXT  O N N 331 
SER H    H N N 332 
SER H2   H N N 333 
SER HA   H N N 334 
SER HB2  H N N 335 
SER HB3  H N N 336 
SER HG   H N N 337 
SER HXT  H N N 338 
THR N    N N N 339 
THR CA   C N S 340 
THR C    C N N 341 
THR O    O N N 342 
THR CB   C N R 343 
THR OG1  O N N 344 
THR CG2  C N N 345 
THR OXT  O N N 346 
THR H    H N N 347 
THR H2   H N N 348 
THR HA   H N N 349 
THR HB   H N N 350 
THR HG1  H N N 351 
THR HG21 H N N 352 
THR HG22 H N N 353 
THR HG23 H N N 354 
THR HXT  H N N 355 
TRP N    N N N 356 
TRP CA   C N S 357 
TRP C    C N N 358 
TRP O    O N N 359 
TRP CB   C N N 360 
TRP CG   C Y N 361 
TRP CD1  C Y N 362 
TRP CD2  C Y N 363 
TRP NE1  N Y N 364 
TRP CE2  C Y N 365 
TRP CE3  C Y N 366 
TRP CZ2  C Y N 367 
TRP CZ3  C Y N 368 
TRP CH2  C Y N 369 
TRP OXT  O N N 370 
TRP H    H N N 371 
TRP H2   H N N 372 
TRP HA   H N N 373 
TRP HB2  H N N 374 
TRP HB3  H N N 375 
TRP HD1  H N N 376 
TRP HE1  H N N 377 
TRP HE3  H N N 378 
TRP HZ2  H N N 379 
TRP HZ3  H N N 380 
TRP HH2  H N N 381 
TRP HXT  H N N 382 
TYR N    N N N 383 
TYR CA   C N S 384 
TYR C    C N N 385 
TYR O    O N N 386 
TYR CB   C N N 387 
TYR CG   C Y N 388 
TYR CD1  C Y N 389 
TYR CD2  C Y N 390 
TYR CE1  C Y N 391 
TYR CE2  C Y N 392 
TYR CZ   C Y N 393 
TYR OH   O N N 394 
TYR OXT  O N N 395 
TYR H    H N N 396 
TYR H2   H N N 397 
TYR HA   H N N 398 
TYR HB2  H N N 399 
TYR HB3  H N N 400 
TYR HD1  H N N 401 
TYR HD2  H N N 402 
TYR HE1  H N N 403 
TYR HE2  H N N 404 
TYR HH   H N N 405 
TYR HXT  H N N 406 
VAL N    N N N 407 
VAL CA   C N S 408 
VAL C    C N N 409 
VAL O    O N N 410 
VAL CB   C N N 411 
VAL CG1  C N N 412 
VAL CG2  C N N 413 
VAL OXT  O N N 414 
VAL H    H N N 415 
VAL H2   H N N 416 
VAL HA   H N N 417 
VAL HB   H N N 418 
VAL HG11 H N N 419 
VAL HG12 H N N 420 
VAL HG13 H N N 421 
VAL HG21 H N N 422 
VAL HG22 H N N 423 
VAL HG23 H N N 424 
VAL HXT  H N N 425 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NXL NAK CAO  sing N N 237 
NXL CAJ CAO  sing N N 238 
NXL CAJ N    sing N N 239 
NXL OAL SAR  sing N N 240 
NXL CAO CAH  sing N N 241 
NXL CAN N    sing N N 242 
NXL CAN OAC  doub N N 243 
NXL OAG SAR  doub N N 244 
NXL N   CA   sing N N 245 
NXL SAR OAE  doub N N 246 
NXL SAR OAD  sing N N 247 
NXL O   C    doub N N 248 
NXL CAH CB   sing N N 249 
NXL CA  C    sing N N 250 
NXL CA  CB   sing N N 251 
NXL C   NAA  sing N N 252 
NXL NAK OAL  sing N N 253 
NXL CAN H1   sing N N 254 
NXL CAJ H2   sing N N 255 
NXL CAJ H3   sing N N 256 
NXL CA  H4   sing N N 257 
NXL NAA H5   sing N N 258 
NXL NAA H6   sing N N 259 
NXL CB  H7   sing N N 260 
NXL CB  H8   sing N N 261 
NXL CAH H9   sing N N 262 
NXL CAH H10  sing N N 263 
NXL CAO H11  sing N N 264 
NXL NAK H12  sing N N 265 
NXL OAD H13  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PO4 P   O1   doub N N 290 
PO4 P   O2   sing N N 291 
PO4 P   O3   sing N N 292 
PO4 P   O4   sing N N 293 
PRO N   CA   sing N N 294 
PRO N   CD   sing N N 295 
PRO N   H    sing N N 296 
PRO CA  C    sing N N 297 
PRO CA  CB   sing N N 298 
PRO CA  HA   sing N N 299 
PRO C   O    doub N N 300 
PRO C   OXT  sing N N 301 
PRO CB  CG   sing N N 302 
PRO CB  HB2  sing N N 303 
PRO CB  HB3  sing N N 304 
PRO CG  CD   sing N N 305 
PRO CG  HG2  sing N N 306 
PRO CG  HG3  sing N N 307 
PRO CD  HD2  sing N N 308 
PRO CD  HD3  sing N N 309 
PRO OXT HXT  sing N N 310 
SER N   CA   sing N N 311 
SER N   H    sing N N 312 
SER N   H2   sing N N 313 
SER CA  C    sing N N 314 
SER CA  CB   sing N N 315 
SER CA  HA   sing N N 316 
SER C   O    doub N N 317 
SER C   OXT  sing N N 318 
SER CB  OG   sing N N 319 
SER CB  HB2  sing N N 320 
SER CB  HB3  sing N N 321 
SER OG  HG   sing N N 322 
SER OXT HXT  sing N N 323 
THR N   CA   sing N N 324 
THR N   H    sing N N 325 
THR N   H2   sing N N 326 
THR CA  C    sing N N 327 
THR CA  CB   sing N N 328 
THR CA  HA   sing N N 329 
THR C   O    doub N N 330 
THR C   OXT  sing N N 331 
THR CB  OG1  sing N N 332 
THR CB  CG2  sing N N 333 
THR CB  HB   sing N N 334 
THR OG1 HG1  sing N N 335 
THR CG2 HG21 sing N N 336 
THR CG2 HG22 sing N N 337 
THR CG2 HG23 sing N N 338 
THR OXT HXT  sing N N 339 
TRP N   CA   sing N N 340 
TRP N   H    sing N N 341 
TRP N   H2   sing N N 342 
TRP CA  C    sing N N 343 
TRP CA  CB   sing N N 344 
TRP CA  HA   sing N N 345 
TRP C   O    doub N N 346 
TRP C   OXT  sing N N 347 
TRP CB  CG   sing N N 348 
TRP CB  HB2  sing N N 349 
TRP CB  HB3  sing N N 350 
TRP CG  CD1  doub Y N 351 
TRP CG  CD2  sing Y N 352 
TRP CD1 NE1  sing Y N 353 
TRP CD1 HD1  sing N N 354 
TRP CD2 CE2  doub Y N 355 
TRP CD2 CE3  sing Y N 356 
TRP NE1 CE2  sing Y N 357 
TRP NE1 HE1  sing N N 358 
TRP CE2 CZ2  sing Y N 359 
TRP CE3 CZ3  doub Y N 360 
TRP CE3 HE3  sing N N 361 
TRP CZ2 CH2  doub Y N 362 
TRP CZ2 HZ2  sing N N 363 
TRP CZ3 CH2  sing Y N 364 
TRP CZ3 HZ3  sing N N 365 
TRP CH2 HH2  sing N N 366 
TRP OXT HXT  sing N N 367 
TYR N   CA   sing N N 368 
TYR N   H    sing N N 369 
TYR N   H2   sing N N 370 
TYR CA  C    sing N N 371 
TYR CA  CB   sing N N 372 
TYR CA  HA   sing N N 373 
TYR C   O    doub N N 374 
TYR C   OXT  sing N N 375 
TYR CB  CG   sing N N 376 
TYR CB  HB2  sing N N 377 
TYR CB  HB3  sing N N 378 
TYR CG  CD1  doub Y N 379 
TYR CG  CD2  sing Y N 380 
TYR CD1 CE1  sing Y N 381 
TYR CD1 HD1  sing N N 382 
TYR CD2 CE2  doub Y N 383 
TYR CD2 HD2  sing N N 384 
TYR CE1 CZ   doub Y N 385 
TYR CE1 HE1  sing N N 386 
TYR CE2 CZ   sing Y N 387 
TYR CE2 HE2  sing N N 388 
TYR CZ  OH   sing N N 389 
TYR OH  HH   sing N N 390 
TYR OXT HXT  sing N N 391 
VAL N   CA   sing N N 392 
VAL N   H    sing N N 393 
VAL N   H2   sing N N 394 
VAL CA  C    sing N N 395 
VAL CA  CB   sing N N 396 
VAL CA  HA   sing N N 397 
VAL C   O    doub N N 398 
VAL C   OXT  sing N N 399 
VAL CB  CG1  sing N N 400 
VAL CB  CG2  sing N N 401 
VAL CB  HB   sing N N 402 
VAL CG1 HG11 sing N N 403 
VAL CG1 HG12 sing N N 404 
VAL CG1 HG13 sing N N 405 
VAL CG2 HG21 sing N N 406 
VAL CG2 HG22 sing N N 407 
VAL CG2 HG23 sing N N 408 
VAL OXT HXT  sing N N 409 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Howard Hughes Medical Institute (HHMI)'           'United States' HHMI-EPI          1 
'National Science Foundation (NSF, United States)' 'United States' DMR-1548924       2 
'Department of Energy (DOE, United States)'        'United States' DE-FC02-02ER63421 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1YLT 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9OR7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022080 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004685 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009362 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021306 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 3   ? -29.836 -3.644  -31.124 1.00 35.15 ? 27  SER A N   1 
ATOM   2    C CA  . SER A 1 3   ? -30.080 -3.893  -32.541 1.00 44.41 ? 27  SER A CA  1 
ATOM   3    C C   . SER A 1 3   ? -28.779 -3.833  -33.342 1.00 38.31 ? 27  SER A C   1 
ATOM   4    O O   . SER A 1 3   ? -28.020 -2.864  -33.239 1.00 34.64 ? 27  SER A O   1 
ATOM   5    C CB  . SER A 1 3   ? -31.102 -2.896  -33.102 1.00 31.47 ? 27  SER A CB  1 
ATOM   6    O OG  . SER A 1 3   ? -30.585 -2.190  -34.217 1.00 45.33 ? 27  SER A OG  1 
ATOM   7    N N   . ALA A 1 4   ? -28.530 -4.882  -34.131 1.00 35.24 ? 28  ALA A N   1 
ATOM   8    C CA  . ALA A 1 4   ? -27.358 -4.957  -35.003 1.00 22.86 ? 28  ALA A CA  1 
ATOM   9    C C   . ALA A 1 4   ? -26.051 -4.901  -34.210 1.00 21.03 ? 28  ALA A C   1 
ATOM   10   O O   . ALA A 1 4   ? -25.071 -4.286  -34.637 1.00 17.37 ? 28  ALA A O   1 
ATOM   11   C CB  . ALA A 1 4   ? -27.395 -3.886  -36.097 1.00 25.13 ? 28  ALA A CB  1 
ATOM   12   N N   . VAL A 1 5   ? -26.024 -5.574  -33.056 1.00 22.44 ? 29  VAL A N   1 
ATOM   13   C CA  . VAL A 1 5   ? -24.895 -5.425  -32.140 1.00 19.61 ? 29  VAL A CA  1 
ATOM   14   C C   . VAL A 1 5   ? -23.601 -5.961  -32.739 1.00 19.96 ? 29  VAL A C   1 
ATOM   15   O O   . VAL A 1 5   ? -22.517 -5.417  -32.478 1.00 17.23 ? 29  VAL A O   1 
ATOM   16   C CB  . VAL A 1 5   ? -25.212 -6.045  -30.768 1.00 16.59 ? 29  VAL A CB  1 
ATOM   17   C CG1 . VAL A 1 5   ? -25.326 -7.562  -30.871 1.00 20.46 ? 29  VAL A CG1 1 
ATOM   18   C CG2 . VAL A 1 5   ? -24.144 -5.665  -29.754 1.00 15.47 ? 29  VAL A CG2 1 
ATOM   19   N N   . GLN A 1 6   ? -23.678 -7.018  -33.551 1.00 17.34 ? 30  GLN A N   1 
ATOM   20   C CA  . GLN A 1 6   ? -22.463 -7.574  -34.140 1.00 16.79 ? 30  GLN A CA  1 
ATOM   21   C C   . GLN A 1 6   ? -21.877 -6.656  -35.202 1.00 17.40 ? 30  GLN A C   1 
ATOM   22   O O   . GLN A 1 6   ? -20.650 -6.503  -35.284 1.00 20.17 ? 30  GLN A O   1 
ATOM   23   C CB  . GLN A 1 6   ? -22.710 -8.976  -34.699 1.00 27.77 ? 30  GLN A CB  1 
ATOM   24   C CG  . GLN A 1 6   ? -23.027 -9.980  -33.623 1.00 17.28 ? 30  GLN A CG  1 
ATOM   25   C CD  . GLN A 1 6   ? -21.810 -10.333 -32.796 1.00 20.20 ? 30  GLN A CD  1 
ATOM   26   O OE1 . GLN A 1 6   ? -20.671 -10.285 -33.275 1.00 24.64 ? 30  GLN A OE1 1 
ATOM   27   N NE2 . GLN A 1 6   ? -22.037 -10.617 -31.527 1.00 19.47 ? 30  GLN A NE2 1 
ATOM   28   N N   . GLN A 1 7   ? -22.728 -6.055  -36.042 1.00 22.42 ? 31  GLN A N   1 
ATOM   29   C CA  . GLN A 1 7   ? -22.230 -5.058  -36.981 1.00 20.72 ? 31  GLN A CA  1 
ATOM   30   C C   . GLN A 1 7   ? -21.512 -3.938  -36.241 1.00 19.65 ? 31  GLN A C   1 
ATOM   31   O O   . GLN A 1 7   ? -20.418 -3.518  -36.642 1.00 16.79 ? 31  GLN A O   1 
ATOM   32   C CB  . GLN A 1 7   ? -23.370 -4.500  -37.849 1.00 21.41 ? 31  GLN A CB  1 
ATOM   33   C CG  . GLN A 1 7   ? -23.950 -5.507  -38.869 1.00 20.36 ? 31  GLN A CG  1 
ATOM   34   C CD  . GLN A 1 7   ? -25.301 -5.070  -39.462 1.00 23.54 ? 31  GLN A CD  1 
ATOM   35   O OE1 . GLN A 1 7   ? -26.339 -5.145  -38.801 1.00 22.54 ? 31  GLN A OE1 1 
ATOM   36   N NE2 . GLN A 1 7   ? -25.285 -4.629  -40.719 1.00 20.97 ? 31  GLN A NE2 1 
ATOM   37   N N   . LYS A 1 8   ? -22.097 -3.475  -35.131 1.00 15.83 ? 32  LYS A N   1 
ATOM   38   C CA  . LYS A 1 8   ? -21.544 -2.319  -34.432 1.00 13.17 ? 32  LYS A CA  1 
ATOM   39   C C   . LYS A 1 8   ? -20.219 -2.648  -33.757 1.00 16.39 ? 32  LYS A C   1 
ATOM   40   O O   . LYS A 1 8   ? -19.266 -1.859  -33.821 1.00 14.33 ? 32  LYS A O   1 
ATOM   41   C CB  . LYS A 1 8   ? -22.560 -1.785  -33.429 1.00 16.08 ? 32  LYS A CB  1 
ATOM   42   C CG  . LYS A 1 8   ? -23.776 -1.123  -34.097 1.00 18.90 ? 32  LYS A CG  1 
ATOM   43   C CD  . LYS A 1 8   ? -24.835 -0.750  -33.076 1.00 24.74 ? 32  LYS A CD  1 
ATOM   44   C CE  . LYS A 1 8   ? -26.007 -0.021  -33.733 1.00 30.09 ? 32  LYS A CE  1 
ATOM   45   N NZ  . LYS A 1 8   ? -25.571 1.206   -34.464 1.00 36.72 ? 32  LYS A NZ  1 
ATOM   46   N N   . LEU A 1 9   ? -20.130 -3.815  -33.125 1.00 15.02 ? 33  LEU A N   1 
ATOM   47   C CA  . LEU A 1 9   ? -18.873 -4.199  -32.508 1.00 12.79 ? 33  LEU A CA  1 
ATOM   48   C C   . LEU A 1 9   ? -17.784 -4.413  -33.555 1.00 14.00 ? 33  LEU A C   1 
ATOM   49   O O   . LEU A 1 9   ? -16.635 -3.999  -33.355 1.00 12.12 ? 33  LEU A O   1 
ATOM   50   C CB  . LEU A 1 9   ? -19.071 -5.423  -31.616 1.00 16.21 ? 33  LEU A CB  1 
ATOM   51   C CG  . LEU A 1 9   ? -19.874 -5.139  -30.338 1.00 10.37 ? 33  LEU A CG  1 
ATOM   52   C CD1 . LEU A 1 9   ? -20.215 -6.439  -29.644 1.00 14.33 ? 33  LEU A CD1 1 
ATOM   53   C CD2 . LEU A 1 9   ? -19.107 -4.219  -29.397 1.00 13.12 ? 33  LEU A CD2 1 
ATOM   54   N N   . ALA A 1 10  ? -18.128 -5.027  -34.693 1.00 13.15 ? 34  ALA A N   1 
ATOM   55   C CA  . ALA A 1 10  ? -17.124 -5.238  -35.734 1.00 13.00 ? 34  ALA A CA  1 
ATOM   56   C C   . ALA A 1 10  ? -16.629 -3.912  -36.302 1.00 12.69 ? 34  ALA A C   1 
ATOM   57   O O   . ALA A 1 10  ? -15.438 -3.758  -36.611 1.00 13.34 ? 34  ALA A O   1 
ATOM   58   C CB  . ALA A 1 10  ? -17.700 -6.127  -36.842 1.00 12.40 ? 34  ALA A CB  1 
ATOM   59   N N   . ALA A 1 11  ? -17.538 -2.942  -36.448 1.00 11.83 ? 35  ALA A N   1 
ATOM   60   C CA  . ALA A 1 11  ? -17.154 -1.646  -36.995 1.00 13.25 ? 35  ALA A CA  1 
ATOM   61   C C   . ALA A 1 11  ? -16.282 -0.880  -36.013 1.00 12.57 ? 35  ALA A C   1 
ATOM   62   O O   . ALA A 1 11  ? -15.331 -0.201  -36.419 1.00 13.07 ? 35  ALA A O   1 
ATOM   63   C CB  . ALA A 1 11  ? -18.408 -0.850  -37.338 1.00 14.03 ? 35  ALA A CB  1 
ATOM   64   N N   . LEU A 1 12  ? -16.590 -0.982  -34.717 1.00 10.34 ? 36  LEU A N   1 
ATOM   65   C CA  . LEU A 1 12  ? -15.729 -0.364  -33.718 1.00 10.05 ? 36  LEU A CA  1 
ATOM   66   C C   . LEU A 1 12  ? -14.330 -0.952  -33.782 1.00 10.06 ? 36  LEU A C   1 
ATOM   67   O O   . LEU A 1 12  ? -13.335 -0.222  -33.797 1.00 13.04 ? 36  LEU A O   1 
ATOM   68   C CB  . LEU A 1 12  ? -16.319 -0.557  -32.324 1.00 11.92 ? 36  LEU A CB  1 
ATOM   69   C CG  . LEU A 1 12  ? -15.410 -0.180  -31.157 1.00 11.75 ? 36  LEU A CG  1 
ATOM   70   C CD1 . LEU A 1 12  ? -15.111 1.324   -31.169 1.00 14.05 ? 36  LEU A CD1 1 
ATOM   71   C CD2 . LEU A 1 12  ? -16.063 -0.622  -29.843 1.00 13.10 ? 36  LEU A CD2 1 
ATOM   72   N N   . GLU A 1 13  ? -14.236 -2.281  -33.848 1.00 11.97 ? 37  GLU A N   1 
ATOM   73   C CA  . GLU A 1 13  ? -12.929 -2.918  -33.940 1.00 11.80 ? 37  GLU A CA  1 
ATOM   74   C C   . GLU A 1 13  ? -12.167 -2.453  -35.181 1.00 12.43 ? 37  GLU A C   1 
ATOM   75   O O   . GLU A 1 13  ? -10.990 -2.094  -35.094 1.00 13.64 ? 37  GLU A O   1 
ATOM   76   C CB  . GLU A 1 13  ? -13.083 -4.436  -33.931 1.00 12.96 ? 37  GLU A CB  1 
ATOM   77   C CG  . GLU A 1 13  ? -11.760 -5.150  -34.023 1.00 11.97 ? 37  GLU A CG  1 
ATOM   78   C CD  . GLU A 1 13  ? -11.913 -6.638  -34.097 1.00 11.46 ? 37  GLU A CD  1 
ATOM   79   O OE1 . GLU A 1 13  ? -12.507 -7.131  -35.074 1.00 12.14 ? 37  GLU A OE1 1 
ATOM   80   O OE2 . GLU A 1 13  ? -11.448 -7.314  -33.165 1.00 13.17 ? 37  GLU A OE2 1 
ATOM   81   N N   . LYS A 1 14  ? -12.824 -2.456  -36.348 1.00 12.48 ? 38  LYS A N   1 
ATOM   82   C CA  . LYS A 1 14  ? -12.126 -2.062  -37.571 1.00 13.27 ? 38  LYS A CA  1 
ATOM   83   C C   . LYS A 1 14  ? -11.625 -0.626  -37.477 1.00 12.88 ? 38  LYS A C   1 
ATOM   84   O O   . LYS A 1 14  ? -10.492 -0.326  -37.873 1.00 16.52 ? 38  LYS A O   1 
ATOM   85   C CB  . LYS A 1 14  ? -13.034 -2.258  -38.789 1.00 16.52 ? 38  LYS A CB  1 
ATOM   86   C CG  . LYS A 1 14  ? -12.350 -1.948  -40.115 1.00 20.04 ? 38  LYS A CG  1 
ATOM   87   C CD  . LYS A 1 14  ? -13.319 -2.103  -41.280 1.00 34.01 ? 38  LYS A CD  1 
ATOM   88   C CE  . LYS A 1 14  ? -14.158 -3.364  -41.148 1.00 37.12 ? 38  LYS A CE  1 
ATOM   89   N NZ  . LYS A 1 14  ? -14.687 -3.822  -42.468 1.00 41.30 ? 38  LYS A NZ  1 
ATOM   90   N N   . SER A 1 15  ? -12.444 0.272   -36.914 1.00 13.74 ? 39  SER A N   1 
ATOM   91   C CA  . SER A 1 15  ? -12.028 1.662   -36.783 1.00 14.27 ? 39  SER A CA  1 
ATOM   92   C C   . SER A 1 15  ? -10.831 1.788   -35.838 1.00 14.15 ? 39  SER A C   1 
ATOM   93   O O   . SER A 1 15  ? -9.935  2.615   -36.056 1.00 15.95 ? 39  SER A O   1 
ATOM   94   C CB  . SER A 1 15  ? -13.212 2.492   -36.286 1.00 15.93 ? 39  SER A CB  1 
ATOM   95   O OG  . SER A 1 15  ? -12.814 3.817   -36.000 1.00 19.11 ? 39  SER A OG  1 
ATOM   96   N N   . SER A 1 16  ? -10.784 0.948   -34.803 1.00 14.14 ? 40  SER A N   1 
ATOM   97   C CA  . SER A 1 16  ? -9.728  1.017   -33.798 1.00 12.55 ? 40  SER A CA  1 
ATOM   98   C C   . SER A 1 16  ? -8.385  0.522   -34.305 1.00 13.96 ? 40  SER A C   1 
ATOM   99   O O   . SER A 1 16  ? -7.355  0.880   -33.730 1.00 16.73 ? 40  SER A O   1 
ATOM   100  C CB  . SER A 1 16  ? -10.128 0.174   -32.589 1.00 14.21 ? 40  SER A CB  1 
ATOM   101  O OG  . SER A 1 16  ? -9.834  -1.201  -32.802 1.00 13.16 ? 40  SER A OG  1 
ATOM   102  N N   . GLY A 1 17  ? -8.371  -0.319  -35.335 1.00 14.84 ? 41  GLY A N   1 
ATOM   103  C CA  . GLY A 1 17  ? -7.149  -0.926  -35.815 1.00 14.74 ? 41  GLY A CA  1 
ATOM   104  C C   . GLY A 1 17  ? -6.635  -2.097  -35.007 1.00 14.78 ? 41  GLY A C   1 
ATOM   105  O O   . GLY A 1 17  ? -5.632  -2.702  -35.405 1.00 19.09 ? 41  GLY A O   1 
ATOM   106  N N   . GLY A 1 18  ? -7.283  -2.446  -33.894 1.00 12.67 ? 42  GLY A N   1 
ATOM   107  C CA  . GLY A 1 18  ? -6.789  -3.530  -33.072 1.00 11.54 ? 42  GLY A CA  1 
ATOM   108  C C   . GLY A 1 18  ? -7.669  -4.762  -33.018 1.00 10.90 ? 42  GLY A C   1 
ATOM   109  O O   . GLY A 1 18  ? -8.376  -5.064  -33.981 1.00 13.31 ? 42  GLY A O   1 
ATOM   110  N N   . ARG A 1 19  ? -7.601  -5.493  -31.903 1.00 10.62 ? 43  ARG A N   1 
ATOM   111  C CA  . ARG A 1 19  ? -8.340  -6.734  -31.707 1.00 11.12 ? 43  ARG A CA  1 
ATOM   112  C C   . ARG A 1 19  ? -9.161  -6.603  -30.431 1.00 8.55  ? 43  ARG A C   1 
ATOM   113  O O   . ARG A 1 19  ? -8.603  -6.411  -29.340 1.00 10.05 ? 43  ARG A O   1 
ATOM   114  C CB  . ARG A 1 19  ? -7.384  -7.935  -31.636 1.00 9.98  ? 43  ARG A CB  1 
ATOM   115  C CG  . ARG A 1 19  ? -8.103  -9.293  -31.596 1.00 8.19  ? 43  ARG A CG  1 
ATOM   116  C CD  . ARG A 1 19  ? -7.104  -10.454 -31.703 1.00 9.07  ? 43  ARG A CD  1 
ATOM   117  N NE  . ARG A 1 19  ? -6.166  -10.542 -30.586 1.00 12.44 ? 43  ARG A NE  1 
ATOM   118  C CZ  . ARG A 1 19  ? -6.297  -11.353 -29.543 1.00 10.40 ? 43  ARG A CZ  1 
ATOM   119  N NH1 . ARG A 1 19  ? -7.331  -12.168 -29.426 1.00 11.60 ? 43  ARG A NH1 1 
ATOM   120  N NH2 . ARG A 1 19  ? -5.363  -11.343 -28.587 1.00 11.08 ? 43  ARG A NH2 1 
ATOM   121  N N   . LEU A 1 20  ? -10.474 -6.704  -30.577 1.00 10.32 ? 44  LEU A N   1 
ATOM   122  C CA  . LEU A 1 20  ? -11.435 -6.429  -29.520 1.00 9.78  ? 44  LEU A CA  1 
ATOM   123  C C   . LEU A 1 20  ? -12.108 -7.721  -29.092 1.00 9.07  ? 44  LEU A C   1 
ATOM   124  O O   . LEU A 1 20  ? -12.537 -8.517  -29.940 1.00 10.13 ? 44  LEU A O   1 
ATOM   125  C CB  . LEU A 1 20  ? -12.509 -5.472  -30.041 1.00 10.88 ? 44  LEU A CB  1 
ATOM   126  C CG  . LEU A 1 20  ? -13.649 -5.105  -29.090 1.00 11.96 ? 44  LEU A CG  1 
ATOM   127  C CD1 . LEU A 1 20  ? -13.115 -4.323  -27.878 1.00 10.80 ? 44  LEU A CD1 1 
ATOM   128  C CD2 . LEU A 1 20  ? -14.733 -4.310  -29.828 1.00 14.62 ? 44  LEU A CD2 1 
ATOM   129  N N   . GLY A 1 21  ? -12.213 -7.921  -27.777 1.00 8.29  ? 45  GLY A N   1 
ATOM   130  C CA  . GLY A 1 21  ? -12.935 -9.059  -27.241 1.00 8.63  ? 45  GLY A CA  1 
ATOM   131  C C   . GLY A 1 21  ? -13.971 -8.626  -26.223 1.00 10.85 ? 45  GLY A C   1 
ATOM   132  O O   . GLY A 1 21  ? -13.654 -7.891  -25.279 1.00 10.26 ? 45  GLY A O   1 
ATOM   133  N N   . VAL A 1 22  ? -15.207 -9.066  -26.399 1.00 9.78  ? 46  VAL A N   1 
ATOM   134  C CA  . VAL A 1 22  ? -16.329 -8.626  -25.576 1.00 10.06 ? 46  VAL A CA  1 
ATOM   135  C C   . VAL A 1 22  ? -17.097 -9.860  -25.123 1.00 10.91 ? 46  VAL A C   1 
ATOM   136  O O   . VAL A 1 22  ? -17.349 -10.775 -25.915 1.00 10.76 ? 46  VAL A O   1 
ATOM   137  C CB  . VAL A 1 22  ? -17.278 -7.684  -26.352 1.00 9.70  ? 46  VAL A CB  1 
ATOM   138  C CG1 . VAL A 1 22  ? -18.514 -7.337  -25.521 1.00 12.50 ? 46  VAL A CG1 1 
ATOM   139  C CG2 . VAL A 1 22  ? -16.569 -6.423  -26.828 1.00 8.79  ? 46  VAL A CG2 1 
ATOM   140  N N   . ALA A 1 23  ? -17.468 -9.900  -23.848 1.00 7.96  ? 47  ALA A N   1 
ATOM   141  C CA  . ALA A 1 23  ? -18.419 -10.899 -23.387 1.00 6.49  ? 47  ALA A CA  1 
ATOM   142  C C   . ALA A 1 23  ? -19.342 -10.231 -22.382 1.00 10.12 ? 47  ALA A C   1 
ATOM   143  O O   . ALA A 1 23  ? -18.870 -9.705  -21.371 1.00 10.14 ? 47  ALA A O   1 
ATOM   144  C CB  . ALA A 1 23  ? -17.720 -12.107 -22.761 1.00 11.60 ? 47  ALA A CB  1 
ATOM   145  N N   . LEU A 1 24  ? -20.644 -10.214 -22.685 1.00 9.45  ? 48  LEU A N   1 
ATOM   146  C CA  . LEU A 1 24  ? -21.669 -9.742  -21.768 1.00 9.82  ? 48  LEU A CA  1 
ATOM   147  C C   . LEU A 1 24  ? -22.491 -10.925 -21.291 1.00 9.84  ? 48  LEU A C   1 
ATOM   148  O O   . LEU A 1 24  ? -22.806 -11.817 -22.080 1.00 10.88 ? 48  LEU A O   1 
ATOM   149  C CB  . LEU A 1 24  ? -22.612 -8.763  -22.471 1.00 13.39 ? 48  LEU A CB  1 
ATOM   150  C CG  . LEU A 1 24  ? -23.909 -8.356  -21.759 1.00 12.81 ? 48  LEU A CG  1 
ATOM   151  C CD1 . LEU A 1 24  ? -23.646 -7.319  -20.678 1.00 15.79 ? 48  LEU A CD1 1 
ATOM   152  C CD2 . LEU A 1 24  ? -24.943 -7.838  -22.757 1.00 20.32 ? 48  LEU A CD2 1 
ATOM   153  N N   . ILE A 1 25  ? -22.826 -10.935 -20.002 1.00 10.13 ? 49  ILE A N   1 
ATOM   154  C CA  . ILE A 1 25  ? -23.876 -11.790 -19.454 1.00 8.53  ? 49  ILE A CA  1 
ATOM   155  C C   . ILE A 1 25  ? -24.933 -10.864 -18.879 1.00 10.83 ? 49  ILE A C   1 
ATOM   156  O O   . ILE A 1 25  ? -24.633 -10.059 -17.988 1.00 10.70 ? 49  ILE A O   1 
ATOM   157  C CB  . ILE A 1 25  ? -23.346 -12.717 -18.345 1.00 9.48  ? 49  ILE A CB  1 
ATOM   158  C CG1 . ILE A 1 25  ? -22.274 -13.672 -18.862 1.00 11.46 ? 49  ILE A CG1 1 
ATOM   159  C CG2 . ILE A 1 25  ? -24.476 -13.520 -17.720 1.00 13.38 ? 49  ILE A CG2 1 
ATOM   160  C CD1 . ILE A 1 25  ? -21.511 -14.373 -17.726 1.00 12.89 ? 49  ILE A CD1 1 
ATOM   161  N N   . ASP A 1 26  ? -26.164 -10.969 -19.383 1.00 12.22 ? 50  ASP A N   1 
ATOM   162  C CA  . ASP A 1 26  ? -27.299 -10.246 -18.816 1.00 10.79 ? 50  ASP A CA  1 
ATOM   163  C C   . ASP A 1 26  ? -28.021 -11.215 -17.888 1.00 12.12 ? 50  ASP A C   1 
ATOM   164  O O   . ASP A 1 26  ? -28.628 -12.180 -18.356 1.00 15.66 ? 50  ASP A O   1 
ATOM   165  C CB  . ASP A 1 26  ? -28.214 -9.742  -19.934 1.00 13.28 ? 50  ASP A CB  1 
ATOM   166  C CG  . ASP A 1 26  ? -29.327 -8.840  -19.421 1.00 15.71 ? 50  ASP A CG  1 
ATOM   167  O OD1 . ASP A 1 26  ? -29.593 -8.871  -18.207 1.00 16.21 ? 50  ASP A OD1 1 
ATOM   168  O OD2 . ASP A 1 26  ? -29.968 -8.134  -20.235 1.00 20.93 ? 50  ASP A OD2 1 
ATOM   169  N N   . THR A 1 27  ? -27.946 -10.974 -16.575 1.00 11.35 ? 51  THR A N   1 
ATOM   170  C CA  . THR A 1 27  ? -28.528 -11.918 -15.622 1.00 13.49 ? 51  THR A CA  1 
ATOM   171  C C   . THR A 1 27  ? -30.043 -11.803 -15.510 1.00 16.07 ? 51  THR A C   1 
ATOM   172  O O   . THR A 1 27  ? -30.653 -12.608 -14.799 1.00 22.38 ? 51  THR A O   1 
ATOM   173  C CB  . THR A 1 27  ? -27.873 -11.827 -14.229 1.00 17.09 ? 51  THR A CB  1 
ATOM   174  O OG1 . THR A 1 27  ? -28.301 -10.627 -13.555 1.00 15.78 ? 51  THR A OG1 1 
ATOM   175  C CG2 . THR A 1 27  ? -26.340 -11.856 -14.335 1.00 17.11 ? 51  THR A CG2 1 
ATOM   176  N N   . ALA A 1 28  ? -30.666 -10.828 -16.178 1.00 17.69 ? 52  ALA A N   1 
ATOM   177  C CA  . ALA A 1 28  ? -32.127 -10.774 -16.196 1.00 14.77 ? 52  ALA A CA  1 
ATOM   178  C C   . ALA A 1 28  ? -32.712 -11.975 -16.933 1.00 24.96 ? 52  ALA A C   1 
ATOM   179  O O   . ALA A 1 28  ? -33.724 -12.541 -16.503 1.00 20.73 ? 52  ALA A O   1 
ATOM   180  C CB  . ALA A 1 28  ? -32.604 -9.462  -16.818 1.00 19.66 ? 52  ALA A CB  1 
ATOM   181  N N   . ASP A 1 29  ? -32.071 -12.399 -18.029 1.00 22.15 ? 53  ASP A N   1 
ATOM   182  C CA  . ASP A 1 29  ? -32.597 -13.485 -18.848 1.00 21.31 ? 53  ASP A CA  1 
ATOM   183  C C   . ASP A 1 29  ? -31.525 -14.480 -19.277 1.00 17.78 ? 53  ASP A C   1 
ATOM   184  O O   . ASP A 1 29  ? -31.811 -15.357 -20.108 1.00 22.95 ? 53  ASP A O   1 
ATOM   185  C CB  . ASP A 1 29  ? -33.276 -12.933 -20.099 1.00 26.22 ? 53  ASP A CB  1 
ATOM   186  C CG  . ASP A 1 29  ? -32.461 -11.847 -20.761 1.00 24.43 ? 53  ASP A CG  1 
ATOM   187  O OD1 . ASP A 1 29  ? -31.217 -11.836 -20.571 1.00 26.04 ? 53  ASP A OD1 1 
ATOM   188  O OD2 . ASP A 1 29  ? -33.049 -11.024 -21.488 1.00 30.36 ? 53  ASP A OD2 1 
ATOM   189  N N   . ASN A 1 30  ? -30.304 -14.367 -18.762 1.00 16.05 ? 54  ASN A N   1 
ATOM   190  C CA  . ASN A 1 30  ? -29.190 -15.262 -19.059 1.00 19.21 ? 54  ASN A CA  1 
ATOM   191  C C   . ASN A 1 30  ? -28.700 -15.132 -20.494 1.00 19.95 ? 54  ASN A C   1 
ATOM   192  O O   . ASN A 1 30  ? -27.952 -15.995 -20.971 1.00 23.66 ? 54  ASN A O   1 
ATOM   193  C CB  . ASN A 1 30  ? -29.508 -16.725 -18.735 1.00 21.97 ? 54  ASN A CB  1 
ATOM   194  C CG  . ASN A 1 30  ? -29.253 -17.061 -17.285 1.00 36.84 ? 54  ASN A CG  1 
ATOM   195  O OD1 . ASN A 1 30  ? -29.890 -17.951 -16.721 1.00 35.79 ? 54  ASN A OD1 1 
ATOM   196  N ND2 . ASN A 1 30  ? -28.363 -16.311 -16.654 1.00 33.97 ? 54  ASN A ND2 1 
ATOM   197  N N   . THR A 1 31  ? -29.092 -14.081 -21.201 1.00 18.80 ? 55  THR A N   1 
ATOM   198  C CA  . THR A 1 31  ? -28.592 -13.888 -22.550 1.00 15.06 ? 55  THR A CA  1 
ATOM   199  C C   . THR A 1 31  ? -27.145 -13.398 -22.527 1.00 15.31 ? 55  THR A C   1 
ATOM   200  O O   . THR A 1 31  ? -26.615 -12.941 -21.500 1.00 15.55 ? 55  THR A O   1 
ATOM   201  C CB  . THR A 1 31  ? -29.483 -12.929 -23.339 1.00 17.59 ? 55  THR A CB  1 
ATOM   202  O OG1 . THR A 1 31  ? -29.566 -11.672 -22.659 1.00 18.99 ? 55  THR A OG1 1 
ATOM   203  C CG2 . THR A 1 31  ? -30.881 -13.516 -23.534 1.00 17.84 ? 55  THR A CG2 1 
ATOM   204  N N   . GLN A 1 32  ? -26.502 -13.512 -23.684 1.00 13.04 ? 56  GLN A N   1 
ATOM   205  C CA  . GLN A 1 32  ? -25.109 -13.129 -23.838 1.00 11.71 ? 56  GLN A CA  1 
ATOM   206  C C   . GLN A 1 32  ? -24.885 -12.398 -25.148 1.00 12.61 ? 56  GLN A C   1 
ATOM   207  O O   . GLN A 1 32  ? -25.585 -12.625 -26.137 1.00 15.90 ? 56  GLN A O   1 
ATOM   208  C CB  . GLN A 1 32  ? -24.107 -14.293 -23.764 1.00 14.78 ? 56  GLN A CB  1 
ATOM   209  C CG  . GLN A 1 32  ? -24.199 -15.155 -22.543 1.00 12.61 ? 56  GLN A CG  1 
ATOM   210  C CD  . GLN A 1 32  ? -23.622 -16.539 -22.757 1.00 15.51 ? 56  GLN A CD  1 
ATOM   211  O OE1 . GLN A 1 32  ? -24.329 -17.494 -23.069 1.00 14.45 ? 56  GLN A OE1 1 
ATOM   212  N NE2 . GLN A 1 32  ? -22.310 -16.648 -22.575 1.00 14.88 ? 56  GLN A NE2 1 
ATOM   213  N N   . VAL A 1 33  ? -23.884 -11.522 -25.137 1.00 13.08 ? 57  VAL A N   1 
ATOM   214  C CA  . VAL A 1 33  ? -23.327 -10.936 -26.344 1.00 11.48 ? 57  VAL A CA  1 
ATOM   215  C C   . VAL A 1 33  ? -21.836 -11.238 -26.327 1.00 9.95  ? 57  VAL A C   1 
ATOM   216  O O   . VAL A 1 33  ? -21.147 -10.937 -25.342 1.00 11.16 ? 57  VAL A O   1 
ATOM   217  C CB  . VAL A 1 33  ? -23.588 -9.419  -26.416 1.00 13.17 ? 57  VAL A CB  1 
ATOM   218  C CG1 . VAL A 1 33  ? -22.809 -8.804  -27.585 1.00 16.68 ? 57  VAL A CG1 1 
ATOM   219  C CG2 . VAL A 1 33  ? -25.074 -9.131  -26.534 1.00 18.41 ? 57  VAL A CG2 1 
ATOM   220  N N   . LEU A 1 34  ? -21.344 -11.836 -27.403 1.00 11.75 ? 59  LEU A N   1 
ATOM   221  C CA  . LEU A 1 34  ? -19.966 -12.283 -27.499 1.00 11.66 ? 59  LEU A CA  1 
ATOM   222  C C   . LEU A 1 34  ? -19.351 -11.742 -28.782 1.00 13.22 ? 59  LEU A C   1 
ATOM   223  O O   . LEU A 1 34  ? -19.988 -11.754 -29.845 1.00 12.84 ? 59  LEU A O   1 
ATOM   224  C CB  . LEU A 1 34  ? -19.941 -13.808 -27.534 1.00 13.39 ? 59  LEU A CB  1 
ATOM   225  C CG  . LEU A 1 34  ? -20.380 -14.449 -26.223 1.00 11.92 ? 59  LEU A CG  1 
ATOM   226  C CD1 . LEU A 1 34  ? -21.251 -15.670 -26.488 1.00 16.84 ? 59  LEU A CD1 1 
ATOM   227  C CD2 . LEU A 1 34  ? -19.198 -14.782 -25.318 1.00 16.99 ? 59  LEU A CD2 1 
ATOM   228  N N   . TYR A 1 35  ? -18.117 -11.253 -28.677 1.00 10.59 ? 60  TYR A N   1 
ATOM   229  C CA  . TYR A 1 35  ? -17.343 -10.848 -29.842 1.00 9.16  ? 60  TYR A CA  1 
ATOM   230  C C   . TYR A 1 35  ? -15.912 -11.278 -29.583 1.00 9.88  ? 60  TYR A C   1 
ATOM   231  O O   . TYR A 1 35  ? -15.298 -10.831 -28.605 1.00 9.22  ? 60  TYR A O   1 
ATOM   232  C CB  . TYR A 1 35  ? -17.428 -9.326  -30.083 1.00 10.52 ? 60  TYR A CB  1 
ATOM   233  C CG  . TYR A 1 35  ? -16.781 -8.907  -31.389 1.00 9.91  ? 60  TYR A CG  1 
ATOM   234  C CD1 . TYR A 1 35  ? -17.509 -8.893  -32.572 1.00 14.27 ? 60  TYR A CD1 1 
ATOM   235  C CD2 . TYR A 1 35  ? -15.436 -8.565  -31.443 1.00 12.28 ? 60  TYR A CD2 1 
ATOM   236  C CE1 . TYR A 1 35  ? -16.921 -8.549  -33.770 1.00 14.70 ? 60  TYR A CE1 1 
ATOM   237  C CE2 . TYR A 1 35  ? -14.832 -8.219  -32.645 1.00 13.37 ? 60  TYR A CE2 1 
ATOM   238  C CZ  . TYR A 1 35  ? -15.580 -8.205  -33.801 1.00 15.30 ? 60  TYR A CZ  1 
ATOM   239  O OH  . TYR A 1 35  ? -14.983 -7.873  -34.996 1.00 16.21 ? 60  TYR A OH  1 
ATOM   240  N N   . ARG A 1 36  ? -15.388 -12.165 -30.431 1.00 10.38 ? 61  ARG A N   1 
ATOM   241  C CA  . ARG A 1 36  ? -14.131 -12.863 -30.154 1.00 7.38  ? 61  ARG A CA  1 
ATOM   242  C C   . ARG A 1 36  ? -14.121 -13.424 -28.737 1.00 9.11  ? 61  ARG A C   1 
ATOM   243  O O   . ARG A 1 36  ? -13.110 -13.371 -28.033 1.00 9.50  ? 61  ARG A O   1 
ATOM   244  C CB  . ARG A 1 36  ? -12.921 -11.967 -30.410 1.00 10.00 ? 61  ARG A CB  1 
ATOM   245  C CG  . ARG A 1 36  ? -12.875 -11.413 -31.823 1.00 12.23 ? 61  ARG A CG  1 
ATOM   246  C CD  . ARG A 1 36  ? -11.549 -10.735 -32.120 1.00 10.46 ? 61  ARG A CD  1 
ATOM   247  N NE  . ARG A 1 36  ? -11.592 -10.032 -33.394 1.00 11.24 ? 61  ARG A NE  1 
ATOM   248  C CZ  . ARG A 1 36  ? -11.532 -10.638 -34.572 1.00 12.34 ? 61  ARG A CZ  1 
ATOM   249  N NH1 . ARG A 1 36  ? -11.387 -11.952 -34.665 1.00 14.53 ? 61  ARG A NH1 1 
ATOM   250  N NH2 . ARG A 1 36  ? -11.623 -9.914  -35.682 1.00 13.41 ? 61  ARG A NH2 1 
ATOM   251  N N   . GLY A 1 37  ? -15.277 -13.949 -28.306 1.00 10.04 ? 62  GLY A N   1 
ATOM   252  C CA  . GLY A 1 37  ? -15.456 -14.369 -26.925 1.00 8.80  ? 62  GLY A CA  1 
ATOM   253  C C   . GLY A 1 37  ? -14.615 -15.557 -26.520 1.00 10.24 ? 62  GLY A C   1 
ATOM   254  O O   . GLY A 1 37  ? -14.403 -15.770 -25.318 1.00 9.83  ? 62  GLY A O   1 
ATOM   255  N N   . ASP A 1 38  ? -14.124 -16.326 -27.497 1.00 9.81  ? 63  ASP A N   1 
ATOM   256  C CA  . ASP A 1 38  ? -13.318 -17.507 -27.236 1.00 8.67  ? 63  ASP A CA  1 
ATOM   257  C C   . ASP A 1 38  ? -11.850 -17.345 -27.629 1.00 9.61  ? 63  ASP A C   1 
ATOM   258  O O   . ASP A 1 38  ? -11.104 -18.331 -27.580 1.00 11.80 ? 63  ASP A O   1 
ATOM   259  C CB  . ASP A 1 38  ? -13.936 -18.738 -27.917 1.00 10.76 ? 63  ASP A CB  1 
ATOM   260  C CG  . ASP A 1 38  ? -15.289 -19.077 -27.351 1.00 13.40 ? 63  ASP A CG  1 
ATOM   261  O OD1 . ASP A 1 38  ? -15.387 -19.313 -26.130 1.00 13.46 ? 63  ASP A OD1 1 
ATOM   262  O OD2 . ASP A 1 38  ? -16.265 -19.089 -28.116 1.00 12.57 ? 63  ASP A OD2 1 
ATOM   263  N N   . GLU A 1 39  ? -11.409 -16.134 -28.003 1.00 8.61  ? 64  GLU A N   1 
ATOM   264  C CA  . GLU A 1 39  ? -9.992  -15.884 -28.221 1.00 10.72 ? 64  GLU A CA  1 
ATOM   265  C C   . GLU A 1 39  ? -9.307  -15.501 -26.910 1.00 10.18 ? 64  GLU A C   1 
ATOM   266  O O   . GLU A 1 39  ? -9.906  -14.878 -26.029 1.00 10.29 ? 64  GLU A O   1 
ATOM   267  C CB  . GLU A 1 39  ? -9.783  -14.772 -29.252 1.00 9.42  ? 64  GLU A CB  1 
ATOM   268  C CG  . GLU A 1 39  ? -10.393 -15.089 -30.592 1.00 10.40 ? 64  GLU A CG  1 
ATOM   269  C CD  . GLU A 1 39  ? -10.139 -14.031 -31.651 1.00 10.73 ? 64  GLU A CD  1 
ATOM   270  O OE1 . GLU A 1 39  ? -9.112  -13.303 -31.582 1.00 12.39 ? 64  GLU A OE1 1 
ATOM   271  O OE2 . GLU A 1 39  ? -10.976 -13.933 -32.572 1.00 10.49 ? 64  GLU A OE2 1 
ATOM   272  N N   . ARG A 1 40  ? -8.047  -15.889 -26.789 1.00 10.85 ? 65  ARG A N   1 
ATOM   273  C CA  . ARG A 1 40  ? -7.258  -15.498 -25.634 1.00 9.81  ? 65  ARG A CA  1 
ATOM   274  C C   . ARG A 1 40  ? -6.792  -14.054 -25.776 1.00 12.76 ? 65  ARG A C   1 
ATOM   275  O O   . ARG A 1 40  ? -6.504  -13.582 -26.885 1.00 10.86 ? 65  ARG A O   1 
ATOM   276  C CB  . ARG A 1 40  ? -6.067  -16.443 -25.470 1.00 9.92  ? 65  ARG A CB  1 
ATOM   277  C CG  . ARG A 1 40  ? -6.487  -17.770 -24.879 1.00 12.02 ? 65  ARG A CG  1 
ATOM   278  C CD  . ARG A 1 40  ? -5.329  -18.680 -24.575 1.00 13.29 ? 65  ARG A CD  1 
ATOM   279  N NE  . ARG A 1 40  ? -5.818  -19.873 -23.892 1.00 14.20 ? 65  ARG A NE  1 
ATOM   280  C CZ  . ARG A 1 40  ? -6.053  -19.964 -22.588 1.00 12.28 ? 65  ARG A CZ  1 
ATOM   281  N NH1 . ARG A 1 40  ? -5.780  -18.965 -21.758 1.00 10.45 ? 65  ARG A NH1 1 
ATOM   282  N NH2 . ARG A 1 40  ? -6.575  -21.092 -22.102 1.00 13.95 ? 65  ARG A NH2 1 
ATOM   283  N N   . PHE A 1 41  ? -6.756  -13.343 -24.648 1.00 8.66  ? 66  PHE A N   1 
ATOM   284  C CA  . PHE A 1 41  ? -6.282  -11.969 -24.551 1.00 7.43  ? 66  PHE A CA  1 
ATOM   285  C C   . PHE A 1 41  ? -5.422  -11.855 -23.302 1.00 10.98 ? 66  PHE A C   1 
ATOM   286  O O   . PHE A 1 41  ? -5.700  -12.520 -22.295 1.00 10.54 ? 66  PHE A O   1 
ATOM   287  C CB  . PHE A 1 41  ? -7.419  -10.934 -24.413 1.00 9.33  ? 66  PHE A CB  1 
ATOM   288  C CG  . PHE A 1 41  ? -8.224  -10.697 -25.663 1.00 8.54  ? 66  PHE A CG  1 
ATOM   289  C CD1 . PHE A 1 41  ? -9.214  -11.572 -26.024 1.00 7.22  ? 66  PHE A CD1 1 
ATOM   290  C CD2 . PHE A 1 41  ? -8.012  -9.582  -26.462 1.00 12.77 ? 66  PHE A CD2 1 
ATOM   291  C CE1 . PHE A 1 41  ? -9.986  -11.353 -27.169 1.00 12.35 ? 66  PHE A CE1 1 
ATOM   292  C CE2 . PHE A 1 41  ? -8.784  -9.350  -27.614 1.00 9.08  ? 66  PHE A CE2 1 
ATOM   293  C CZ  . PHE A 1 41  ? -9.774  -10.236 -27.956 1.00 9.82  ? 66  PHE A CZ  1 
ATOM   294  N N   . PRO A 1 42  ? -4.376  -11.023 -23.331 1.00 10.75 ? 67  PRO A N   1 
ATOM   295  C CA  . PRO A 1 42  ? -3.601  -10.776 -22.109 1.00 9.90  ? 67  PRO A CA  1 
ATOM   296  C C   . PRO A 1 42  ? -4.436  -10.037 -21.071 1.00 10.49 ? 67  PRO A C   1 
ATOM   297  O O   . PRO A 1 42  ? -5.049  -9.005  -21.363 1.00 12.99 ? 67  PRO A O   1 
ATOM   298  C CB  . PRO A 1 42  ? -2.415  -9.932  -22.585 1.00 14.02 ? 67  PRO A CB  1 
ATOM   299  C CG  . PRO A 1 42  ? -2.565  -9.743  -24.030 1.00 13.93 ? 67  PRO A CG  1 
ATOM   300  C CD  . PRO A 1 42  ? -3.881  -10.253 -24.480 1.00 10.75 ? 67  PRO A CD  1 
ATOM   301  N N   . MET A 1 43  ? -4.440  -10.566 -19.848 1.00 9.09  ? 68  MET A N   1 
ATOM   302  C CA  . MET A 1 43  ? -5.351  -10.075 -18.823 1.00 9.78  ? 68  MET A CA  1 
ATOM   303  C C   . MET A 1 43  ? -4.794  -8.801  -18.180 1.00 9.45  ? 68  MET A C   1 
ATOM   304  O O   . MET A 1 43  ? -5.562  -7.921  -17.764 1.00 10.50 ? 68  MET A O   1 
ATOM   305  C CB  . MET A 1 43  ? -5.374  -11.156 -17.753 1.00 9.43  ? 68  MET A CB  1 
ATOM   306  C CG  . MET A 1 43  ? -6.284  -12.314 -18.109 1.00 12.72 ? 68  MET A CG  1 
ATOM   307  S SD  . MET A 1 43  ? -6.548  -13.422 -16.746 1.00 10.53 ? 68  MET A SD  1 
ATOM   308  C CE  . MET A 1 43  ? -5.070  -14.404 -16.839 1.00 11.36 ? 68  MET A CE  1 
ATOM   309  N N   . CYS A 1 44  ? -3.467  -8.678  -18.096 1.00 9.49  ? 69  CYS A N   1 
ATOM   310  C CA  . CYS A 1 44  ? -2.781  -7.591  -17.382 1.00 8.70  ? 69  CYS A CA  1 
ATOM   311  C C   . CYS A 1 44  ? -3.374  -7.466  -15.981 1.00 8.00  ? 69  CYS A C   1 
ATOM   312  O O   . CYS A 1 44  ? -3.568  -8.496  -15.321 1.00 10.05 ? 69  CYS A O   1 
ATOM   313  C CB  . CYS A 1 44  ? -2.735  -6.311  -18.196 1.00 10.52 ? 69  CYS A CB  1 
ATOM   314  S SG  . CYS A 1 44  ? -1.942  -6.535  -19.808 1.00 12.23 ? 69  CYS A SG  1 
ATOM   315  N N   . SER A 1 45  ? -3.663  -6.253  -15.506 1.00 9.01  ? 70  SER A N   1 
ATOM   316  C CA  . SER A 1 45  ? -4.078  -6.049  -14.122 1.00 8.53  ? 70  SER A CA  1 
ATOM   317  C C   . SER A 1 45  ? -5.452  -6.636  -13.825 1.00 7.55  ? 70  SER A C   1 
ATOM   318  O O   . SER A 1 45  ? -5.810  -6.747  -12.647 1.00 9.24  ? 70  SER A O   1 
ATOM   319  C CB  . SER A 1 45  ? -4.114  -4.557  -13.800 1.00 9.74  ? 70  SER A CB  1 
ATOM   320  O OG  . SER A 1 45  ? -2.808  -4.028  -13.584 1.00 11.76 ? 70  SER A OG  1 
ATOM   321  N N   . THR A 1 46  ? -6.251  -6.997  -14.849 1.00 7.51  ? 71  THR A N   1 
ATOM   322  C CA  . THR A 1 46  ? -7.529  -7.643  -14.542 1.00 10.26 ? 71  THR A CA  1 
ATOM   323  C C   . THR A 1 46  ? -7.358  -9.002  -13.874 1.00 10.60 ? 71  THR A C   1 
ATOM   324  O O   . THR A 1 46  ? -8.307  -9.491  -13.250 1.00 10.93 ? 71  THR A O   1 
ATOM   325  C CB  . THR A 1 46  ? -8.456  -7.753  -15.766 1.00 9.53  ? 71  THR A CB  1 
ATOM   326  O OG1 . THR A 1 46  ? -7.969  -8.729  -16.698 1.00 11.07 ? 71  THR A OG1 1 
ATOM   327  C CG2 . THR A 1 46  ? -8.617  -6.390  -16.453 1.00 9.10  ? 71  THR A CG2 1 
ATOM   328  N N   . SER A 1 47  ? -6.171  -9.611  -13.987 1.00 10.06 ? 72  SER A N   1 
ATOM   329  C CA  . SER A 1 47  ? -5.893  -10.863 -13.299 1.00 9.83  ? 72  SER A CA  1 
ATOM   330  C C   . SER A 1 47  ? -5.892  -10.704 -11.781 1.00 10.49 ? 72  SER A C   1 
ATOM   331  O O   . SER A 1 47  ? -6.009  -11.707 -11.065 1.00 11.02 ? 72  SER A O   1 
ATOM   332  C CB  . SER A 1 47  ? -4.553  -11.423 -13.784 1.00 10.68 ? 72  SER A CB  1 
ATOM   333  O OG  . SER A 1 47  ? -3.505  -10.560 -13.395 1.00 11.86 ? 72  SER A OG  1 
ATOM   334  N N   . LYS A 1 48  ? -5.775  -9.475  -11.277 1.00 10.64 ? 73  LYS A N   1 
ATOM   335  C CA  . LYS A 1 48  ? -5.764  -9.238  -9.834  1.00 9.25  ? 73  LYS A CA  1 
ATOM   336  C C   . LYS A 1 48  ? -7.083  -9.636  -9.169  1.00 8.32  ? 73  LYS A C   1 
ATOM   337  O O   . LYS A 1 48  ? -7.097  -9.972  -7.977  1.00 10.37 ? 73  LYS A O   1 
ATOM   338  C CB  . LYS A 1 48  ? -5.412  -7.773  -9.555  1.00 10.54 ? 73  LYS A CB  1 
ATOM   339  C CG  . LYS A 1 48  ? -4.004  -7.407  -9.994  1.00 10.24 ? 73  LYS A CG  1 
ATOM   340  C CD  . LYS A 1 48  ? -3.757  -5.929  -9.830  1.00 9.39  ? 73  LYS A CD  1 
ATOM   341  C CE  . LYS A 1 48  ? -2.370  -5.572  -10.359 1.00 10.67 ? 73  LYS A CE  1 
ATOM   342  N NZ  . LYS A 1 48  ? -2.106  -4.117  -10.248 1.00 11.98 ? 73  LYS A NZ  1 
ATOM   343  N N   . VAL A 1 49  ? -8.201  -9.629  -9.911  1.00 9.28  ? 74  VAL A N   1 
ATOM   344  C CA  . VAL A 1 49  ? -9.469  -10.104 -9.333  1.00 8.08  ? 74  VAL A CA  1 
ATOM   345  C C   . VAL A 1 49  ? -9.365  -11.574 -8.922  1.00 8.32  ? 74  VAL A C   1 
ATOM   346  O O   . VAL A 1 49  ? -9.809  -11.962 -7.837  1.00 10.36 ? 74  VAL A O   1 
ATOM   347  C CB  . VAL A 1 49  ? -10.645 -9.865  -10.297 1.00 8.91  ? 74  VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 49  ? -11.941 -10.464 -9.723  1.00 11.52 ? 74  VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 49  ? -10.812 -8.383  -10.579 1.00 12.82 ? 74  VAL A CG2 1 
ATOM   350  N N   . MET A 1 50  ? -8.810  -12.421 -9.796  1.00 8.56  ? 75  MET A N   1 
ATOM   351  C CA  . MET A 1 50  ? -8.624  -13.829 -9.448  1.00 9.93  ? 75  MET A CA  1 
ATOM   352  C C   . MET A 1 50  ? -7.735  -14.001 -8.225  1.00 8.68  ? 75  MET A C   1 
ATOM   353  O O   . MET A 1 50  ? -8.004  -14.860 -7.373  1.00 9.55  ? 75  MET A O   1 
ATOM   354  C CB  . MET A 1 50  ? -7.996  -14.584 -10.614 1.00 11.28 ? 75  MET A CB  1 
ATOM   355  C CG  . MET A 1 50  ? -8.276  -16.089 -10.679 1.00 13.45 ? 75  MET A CG  1 
ATOM   356  S SD  . MET A 1 50  ? -9.952  -16.742 -10.688 1.00 12.65 ? 75  MET A SD  1 
ATOM   357  C CE  . MET A 1 50  ? -10.187 -16.840 -12.456 1.00 13.51 ? 75  MET A CE  1 
ATOM   358  N N   . ALA A 1 51  ? -6.642  -13.223 -8.144  1.00 7.37  ? 76  ALA A N   1 
ATOM   359  C CA  . ALA A 1 51  ? -5.702  -13.387 -7.043  1.00 8.47  ? 76  ALA A CA  1 
ATOM   360  C C   . ALA A 1 51  ? -6.316  -12.938 -5.721  1.00 8.71  ? 76  ALA A C   1 
ATOM   361  O O   . ALA A 1 51  ? -6.182  -13.629 -4.708  1.00 10.11 ? 76  ALA A O   1 
ATOM   362  C CB  . ALA A 1 51  ? -4.406  -12.619 -7.320  1.00 9.82  ? 76  ALA A CB  1 
ATOM   363  N N   . ALA A 1 52  ? -7.040  -11.814 -5.721  1.00 9.58  ? 77  ALA A N   1 
ATOM   364  C CA  . ALA A 1 52  ? -7.718  -11.374 -4.502  1.00 8.78  ? 77  ALA A CA  1 
ATOM   365  C C   . ALA A 1 52  ? -8.825  -12.344 -4.092  1.00 8.65  ? 77  ALA A C   1 
ATOM   366  O O   . ALA A 1 52  ? -9.009  -12.622 -2.901  1.00 9.79  ? 77  ALA A O   1 
ATOM   367  C CB  . ALA A 1 52  ? -8.285  -9.959  -4.693  1.00 10.06 ? 77  ALA A CB  1 
ATOM   368  N N   . ALA A 1 53  ? -9.591  -12.852 -5.061  1.00 8.29  ? 78  ALA A N   1 
ATOM   369  C CA  . ALA A 1 53  ? -10.636 -13.820 -4.751  1.00 11.13 ? 78  ALA A CA  1 
ATOM   370  C C   . ALA A 1 53  ? -10.047 -15.098 -4.167  1.00 9.00  ? 78  ALA A C   1 
ATOM   371  O O   . ALA A 1 53  ? -10.649 -15.715 -3.280  1.00 8.92  ? 78  ALA A O   1 
ATOM   372  C CB  . ALA A 1 53  ? -11.437 -14.117 -6.016  1.00 10.67 ? 78  ALA A CB  1 
ATOM   373  N N   . ALA A 1 54  ? -8.863  -15.498 -4.642  1.00 9.37  ? 79  ALA A N   1 
ATOM   374  C CA  . ALA A 1 54  ? -8.251  -16.719 -4.137  1.00 8.55  ? 79  ALA A CA  1 
ATOM   375  C C   . ALA A 1 54  ? -7.825  -16.558 -2.683  1.00 8.83  ? 79  ALA A C   1 
ATOM   376  O O   . ALA A 1 54  ? -7.974  -17.484 -1.880  1.00 10.54 ? 79  ALA A O   1 
ATOM   377  C CB  . ALA A 1 54  ? -7.053  -17.094 -5.007  1.00 9.12  ? 79  ALA A CB  1 
ATOM   378  N N   . VAL A 1 55  ? -7.305  -15.381 -2.317  1.00 9.65  ? 80  VAL A N   1 
ATOM   379  C CA  . VAL A 1 55  ? -6.974  -15.123 -0.920  1.00 9.16  ? 80  VAL A CA  1 
ATOM   380  C C   . VAL A 1 55  ? -8.243  -15.037 -0.071  1.00 10.74 ? 80  VAL A C   1 
ATOM   381  O O   . VAL A 1 55  ? -8.283  -15.535 1.062   1.00 9.48  ? 80  VAL A O   1 
ATOM   382  C CB  . VAL A 1 55  ? -6.092  -13.866 -0.810  1.00 7.94  ? 80  VAL A CB  1 
ATOM   383  C CG1 . VAL A 1 55  ? -5.889  -13.469 0.648   1.00 11.28 ? 80  VAL A CG1 1 
ATOM   384  C CG2 . VAL A 1 55  ? -4.736  -14.125 -1.463  1.00 10.24 ? 80  VAL A CG2 1 
ATOM   385  N N   . LEU A 1 56  ? -9.298  -14.407 -0.602  1.00 9.34  ? 81  LEU A N   1 
ATOM   386  C CA  . LEU A 1 56  ? -10.582 -14.417 0.092   1.00 10.91 ? 81  LEU A CA  1 
ATOM   387  C C   . LEU A 1 56  ? -11.052 -15.839 0.367   1.00 9.01  ? 81  LEU A C   1 
ATOM   388  O O   . LEU A 1 56  ? -11.532 -16.138 1.464   1.00 9.96  ? 81  LEU A O   1 
ATOM   389  C CB  . LEU A 1 56  ? -11.634 -13.645 -0.712  1.00 8.14  ? 81  LEU A CB  1 
ATOM   390  C CG  . LEU A 1 56  ? -11.632 -12.115 -0.570  1.00 8.66  ? 81  LEU A CG  1 
ATOM   391  C CD1 . LEU A 1 56  ? -12.598 -11.508 -1.570  1.00 10.58 ? 81  LEU A CD1 1 
ATOM   392  C CD2 . LEU A 1 56  ? -11.989 -11.653 0.832   1.00 11.65 ? 81  LEU A CD2 1 
ATOM   393  N N   . LYS A 1 57  ? -10.938 -16.736 -0.625  1.00 10.32 ? 82  LYS A N   1 
ATOM   394  C CA  . LYS A 1 57  ? -11.337 -18.123 -0.385  1.00 9.56  ? 82  LYS A CA  1 
ATOM   395  C C   . LYS A 1 57  ? -10.476 -18.767 0.700   1.00 9.08  ? 82  LYS A C   1 
ATOM   396  O O   . LYS A 1 57  ? -10.993 -19.503 1.547   1.00 9.58  ? 82  LYS A O   1 
ATOM   397  C CB  . LYS A 1 57  ? -11.313 -18.926 -1.692  1.00 8.85  ? 82  LYS A CB  1 
ATOM   398  C CG  . LYS A 1 57  ? -11.551 -20.452 -1.544  1.00 11.24 ? 82  LYS A CG  1 
ATOM   399  C CD  . LYS A 1 57  ? -12.927 -20.833 -0.955  1.00 12.67 ? 82  LYS A CD  1 
ATOM   400  C CE  . LYS A 1 57  ? -14.063 -20.465 -1.930  1.00 15.14 ? 82  LYS A CE  1 
ATOM   401  N NZ  . LYS A 1 57  ? -15.427 -20.841 -1.390  1.00 11.91 ? 82  LYS A NZ  1 
ATOM   402  N N   . GLN A 1 58  ? -9.165  -18.479 0.714   1.00 9.25  ? 83  GLN A N   1 
ATOM   403  C CA  . GLN A 1 58  ? -8.320  -19.029 1.774   1.00 9.05  ? 83  GLN A CA  1 
ATOM   404  C C   . GLN A 1 58  ? -8.779  -18.553 3.143   1.00 8.66  ? 83  GLN A C   1 
ATOM   405  O O   . GLN A 1 58  ? -8.785  -19.331 4.105   1.00 8.69  ? 83  GLN A O   1 
ATOM   406  C CB  . GLN A 1 58  ? -6.851  -18.664 1.561   1.00 9.20  ? 83  GLN A CB  1 
ATOM   407  C CG  . GLN A 1 58  ? -6.219  -19.393 0.384   1.00 8.33  ? 83  GLN A CG  1 
ATOM   408  C CD  . GLN A 1 58  ? -4.716  -19.280 0.396   1.00 15.05 ? 83  GLN A CD  1 
ATOM   409  O OE1 . GLN A 1 58  ? -4.176  -18.291 0.872   1.00 15.32 ? 83  GLN A OE1 1 
ATOM   410  N NE2 . GLN A 1 58  ? -4.033  -20.288 -0.136  1.00 15.74 ? 83  GLN A NE2 1 
ATOM   411  N N   . SER A 1 59  ? -9.189  -17.286 3.243   1.00 10.49 ? 84  SER A N   1 
ATOM   412  C CA  . SER A 1 59  ? -9.649  -16.726 4.513   1.00 8.58  ? 84  SER A CA  1 
ATOM   413  C C   . SER A 1 59  ? -10.946 -17.359 5.017   1.00 10.60 ? 84  SER A C   1 
ATOM   414  O O   . SER A 1 59  ? -11.323 -17.127 6.172   1.00 9.58  ? 84  SER A O   1 
ATOM   415  C CB  . SER A 1 59  ? -9.740  -15.193 4.412   1.00 9.96  ? 84  SER A CB  1 
ATOM   416  O OG  . SER A 1 59  ? -10.912 -14.763 3.731   1.00 9.64  ? 84  SER A OG  1 
ATOM   417  N N   . GLU A 1 60  ? -11.642 -18.149 4.187   1.00 9.30  ? 85  GLU A N   1 
ATOM   418  C CA  . GLU A 1 60  ? -12.830 -18.848 4.681   1.00 10.14 ? 85  GLU A CA  1 
ATOM   419  C C   . GLU A 1 60  ? -12.468 -19.917 5.701   1.00 9.33  ? 85  GLU A C   1 
ATOM   420  O O   . GLU A 1 60  ? -13.301 -20.260 6.544   1.00 12.52 ? 85  GLU A O   1 
ATOM   421  C CB  . GLU A 1 60  ? -13.632 -19.466 3.532   1.00 8.93  ? 85  GLU A CB  1 
ATOM   422  C CG  . GLU A 1 60  ? -14.185 -18.416 2.554   1.00 9.35  ? 85  GLU A CG  1 
ATOM   423  C CD  . GLU A 1 60  ? -15.047 -18.974 1.444   1.00 12.24 ? 85  GLU A CD  1 
ATOM   424  O OE1 . GLU A 1 60  ? -15.699 -20.030 1.614   1.00 12.24 ? 85  GLU A OE1 1 
ATOM   425  O OE2 . GLU A 1 60  ? -15.048 -18.338 0.372   1.00 11.29 ? 85  GLU A OE2 1 
ATOM   426  N N   . THR A 1 61  ? -11.248 -20.459 5.639   1.00 9.41  ? 86  THR A N   1 
ATOM   427  C CA  . THR A 1 61  ? -10.819 -21.485 6.581   1.00 9.45  ? 86  THR A CA  1 
ATOM   428  C C   . THR A 1 61  ? -9.643  -21.069 7.453   1.00 10.50 ? 86  THR A C   1 
ATOM   429  O O   . THR A 1 61  ? -9.508  -21.601 8.560   1.00 14.13 ? 86  THR A O   1 
ATOM   430  C CB  . THR A 1 61  ? -10.479 -22.800 5.857   1.00 11.80 ? 86  THR A CB  1 
ATOM   431  O OG1 . THR A 1 61  ? -9.497  -22.538 4.840   1.00 12.67 ? 86  THR A OG1 1 
ATOM   432  C CG2 . THR A 1 61  ? -11.739 -23.407 5.198   1.00 9.84  ? 86  THR A CG2 1 
ATOM   433  N N   . GLN A 1 62  ? -8.782  -20.152 6.987   1.00 12.96 ? 87  GLN A N   1 
ATOM   434  C CA  . GLN A 1 62  ? -7.760  -19.501 7.820   1.00 10.83 ? 87  GLN A CA  1 
ATOM   435  C C   . GLN A 1 62  ? -8.372  -18.174 8.248   1.00 12.50 ? 87  GLN A C   1 
ATOM   436  O O   . GLN A 1 62  ? -8.254  -17.159 7.562   1.00 13.40 ? 87  GLN A O   1 
ATOM   437  C CB  . GLN A 1 62  ? -6.463  -19.302 7.039   1.00 11.78 ? 87  GLN A CB  1 
ATOM   438  C CG  . GLN A 1 62  ? -5.818  -20.594 6.550   1.00 11.44 ? 87  GLN A CG  1 
ATOM   439  C CD  . GLN A 1 62  ? -4.649  -20.314 5.637   1.00 12.15 ? 87  GLN A CD  1 
ATOM   440  O OE1 . GLN A 1 62  ? -4.758  -20.457 4.414   1.00 13.36 ? 87  GLN A OE1 1 
ATOM   441  N NE2 . GLN A 1 62  ? -3.516  -19.939 6.219   1.00 14.92 ? 87  GLN A NE2 1 
ATOM   442  N N   . LYS A 1 63  ? -9.039  -18.193 9.404   1.00 13.48 ? 88  LYS A N   1 
ATOM   443  C CA  . LYS A 1 63  ? -10.026 -17.170 9.719   1.00 12.94 ? 88  LYS A CA  1 
ATOM   444  C C   . LYS A 1 63  ? -9.422  -15.810 10.035  1.00 12.57 ? 88  LYS A C   1 
ATOM   445  O O   . LYS A 1 63  ? -10.134 -14.801 9.941   1.00 15.03 ? 88  LYS A O   1 
ATOM   446  C CB  . LYS A 1 63  ? -10.915 -17.654 10.865  1.00 13.86 ? 88  LYS A CB  1 
ATOM   447  C CG  . LYS A 1 63  ? -11.987 -18.634 10.413  1.00 14.79 ? 88  LYS A CG  1 
ATOM   448  C CD  . LYS A 1 63  ? -12.468 -18.286 9.002   1.00 27.67 ? 88  LYS A CD  1 
ATOM   449  C CE  . LYS A 1 63  ? -13.482 -17.127 9.007   1.00 32.89 ? 88  LYS A CE  1 
ATOM   450  N NZ  . LYS A 1 63  ? -13.492 -16.317 7.732   1.00 19.70 ? 88  LYS A NZ  1 
ATOM   451  N N   . GLN A 1 64  ? -8.143  -15.755 10.396  1.00 14.14 ? 89  GLN A N   1 
ATOM   452  C CA  . GLN A 1 64  ? -7.453  -14.498 10.636  1.00 15.72 ? 89  GLN A CA  1 
ATOM   453  C C   . GLN A 1 64  ? -6.501  -14.128 9.509   1.00 17.78 ? 89  GLN A C   1 
ATOM   454  O O   . GLN A 1 64  ? -5.727  -13.173 9.655   1.00 13.87 ? 89  GLN A O   1 
ATOM   455  C CB  . GLN A 1 64  ? -6.707  -14.541 11.974  1.00 15.64 ? 89  GLN A CB  1 
ATOM   456  C CG  . GLN A 1 64  ? -7.492  -15.203 13.110  1.00 23.07 ? 89  GLN A CG  1 
ATOM   457  C CD  . GLN A 1 64  ? -8.837  -14.541 13.325  1.00 22.27 ? 89  GLN A CD  1 
ATOM   458  O OE1 . GLN A 1 64  ? -8.957  -13.319 13.228  1.00 23.80 ? 89  GLN A OE1 1 
ATOM   459  N NE2 . GLN A 1 64  ? -9.861  -15.343 13.601  1.00 19.73 ? 89  GLN A NE2 1 
ATOM   460  N N   . LEU A 1 65  ? -6.565  -14.838 8.374   1.00 12.55 ? 90  LEU A N   1 
ATOM   461  C CA  . LEU A 1 65  ? -5.579  -14.635 7.317   1.00 13.04 ? 90  LEU A CA  1 
ATOM   462  C C   . LEU A 1 65  ? -5.529  -13.181 6.847   1.00 12.21 ? 90  LEU A C   1 
ATOM   463  O O   . LEU A 1 65  ? -4.440  -12.639 6.619   1.00 12.85 ? 90  LEU A O   1 
ATOM   464  C CB  . LEU A 1 65  ? -5.882  -15.565 6.140   1.00 13.79 ? 90  LEU A CB  1 
ATOM   465  C CG  . LEU A 1 65  ? -4.859  -15.493 5.008   1.00 10.48 ? 90  LEU A CG  1 
ATOM   466  C CD1 . LEU A 1 65  ? -3.507  -15.920 5.534   1.00 12.98 ? 90  LEU A CD1 1 
ATOM   467  C CD2 . LEU A 1 65  ? -5.294  -16.383 3.861   1.00 12.23 ? 90  LEU A CD2 1 
ATOM   468  N N   . LEU A 1 66  ? -6.688  -12.528 6.693   1.00 10.67 ? 91  LEU A N   1 
ATOM   469  C CA  . LEU A 1 66  ? -6.671  -11.183 6.118   1.00 11.72 ? 91  LEU A CA  1 
ATOM   470  C C   . LEU A 1 66  ? -5.961  -10.166 7.006   1.00 13.18 ? 91  LEU A C   1 
ATOM   471  O O   . LEU A 1 66  ? -5.522  -9.128  6.501   1.00 12.72 ? 91  LEU A O   1 
ATOM   472  C CB  . LEU A 1 66  ? -8.082  -10.715 5.765   1.00 11.82 ? 91  LEU A CB  1 
ATOM   473  C CG  . LEU A 1 66  ? -8.770  -11.524 4.663   1.00 14.51 ? 91  LEU A CG  1 
ATOM   474  C CD1 . LEU A 1 66  ? -10.112 -10.926 4.330   1.00 14.92 ? 91  LEU A CD1 1 
ATOM   475  C CD2 . LEU A 1 66  ? -7.893  -11.617 3.413   1.00 16.77 ? 91  LEU A CD2 1 
ATOM   476  N N   A ASN A 1 67  ? -5.824  -10.445 8.298   0.59 14.08 ? 92  ASN A N   1 
ATOM   477  N N   B ASN A 1 67  ? -5.830  -10.421 8.309   0.41 14.12 ? 92  ASN A N   1 
ATOM   478  C CA  A ASN A 1 67  ? -5.156  -9.515  9.198   0.59 14.76 ? 92  ASN A CA  1 
ATOM   479  C CA  B ASN A 1 67  ? -5.136  -9.469  9.173   0.41 14.82 ? 92  ASN A CA  1 
ATOM   480  C C   A ASN A 1 67  ? -3.674  -9.814  9.389   0.59 15.36 ? 92  ASN A C   1 
ATOM   481  C C   B ASN A 1 67  ? -3.655  -9.789  9.366   0.41 15.41 ? 92  ASN A C   1 
ATOM   482  O O   A ASN A 1 67  ? -3.011  -9.110  10.160  0.59 17.77 ? 92  ASN A O   1 
ATOM   483  O O   B ASN A 1 67  ? -2.979  -9.090  10.130  0.41 17.71 ? 92  ASN A O   1 
ATOM   484  C CB  A ASN A 1 67  ? -5.893  -9.456  10.538  0.59 19.00 ? 92  ASN A CB  1 
ATOM   485  C CB  B ASN A 1 67  ? -5.847  -9.298  10.525  0.41 18.98 ? 92  ASN A CB  1 
ATOM   486  C CG  A ASN A 1 67  ? -7.396  -9.355  10.357  0.59 17.54 ? 92  ASN A CG  1 
ATOM   487  C CG  B ASN A 1 67  ? -6.042  -10.606 11.264  0.41 19.28 ? 92  ASN A CG  1 
ATOM   488  O OD1 A ASN A 1 67  ? -7.885  -8.459  9.670   0.59 23.39 ? 92  ASN A OD1 1 
ATOM   489  O OD1 B ASN A 1 67  ? -5.076  -11.271 11.632  0.41 19.14 ? 92  ASN A OD1 1 
ATOM   490  N ND2 A ASN A 1 67  ? -8.136  -10.273 10.972  0.59 26.27 ? 92  ASN A ND2 1 
ATOM   491  N ND2 B ASN A 1 67  ? -7.299  -10.970 11.507  0.41 26.33 ? 92  ASN A ND2 1 
ATOM   492  N N   . GLN A 1 68  ? -3.132  -10.794 8.674   1.00 13.08 ? 93  GLN A N   1 
ATOM   493  C CA  . GLN A 1 68  ? -1.746  -11.198 8.873   1.00 16.44 ? 93  GLN A CA  1 
ATOM   494  C C   . GLN A 1 68  ? -0.805  -10.183 8.231   1.00 16.33 ? 93  GLN A C   1 
ATOM   495  O O   . GLN A 1 68  ? -0.977  -9.843  7.060   1.00 15.67 ? 93  GLN A O   1 
ATOM   496  C CB  . GLN A 1 68  ? -1.538  -12.576 8.252   1.00 18.96 ? 93  GLN A CB  1 
ATOM   497  C CG  . GLN A 1 68  ? -0.090  -12.986 8.058   1.00 22.63 ? 93  GLN A CG  1 
ATOM   498  C CD  . GLN A 1 68  ? 0.032   -14.177 7.134   1.00 32.05 ? 93  GLN A CD  1 
ATOM   499  O OE1 . GLN A 1 68  ? -0.635  -15.194 7.332   1.00 34.33 ? 93  GLN A OE1 1 
ATOM   500  N NE2 . GLN A 1 68  ? 0.872   -14.056 6.110   1.00 37.25 ? 93  GLN A NE2 1 
ATOM   501  N N   . PRO A 1 69  ? 0.184   -9.676  8.958   1.00 16.86 ? 94  PRO A N   1 
ATOM   502  C CA  . PRO A 1 69  ? 1.123   -8.719  8.358   1.00 16.53 ? 94  PRO A CA  1 
ATOM   503  C C   . PRO A 1 69  ? 2.097   -9.392  7.400   1.00 14.75 ? 94  PRO A C   1 
ATOM   504  O O   . PRO A 1 69  ? 2.475   -10.554 7.567   1.00 16.20 ? 94  PRO A O   1 
ATOM   505  C CB  . PRO A 1 69  ? 1.838   -8.121  9.575   1.00 19.40 ? 94  PRO A CB  1 
ATOM   506  C CG  . PRO A 1 69  ? 1.786   -9.205  10.595  1.00 25.44 ? 94  PRO A CG  1 
ATOM   507  C CD  . PRO A 1 69  ? 0.433   -9.869  10.397  1.00 16.85 ? 94  PRO A CD  1 
ATOM   508  N N   . VAL A 1 70  ? 2.469   -8.649  6.358   1.00 12.15 ? 95  VAL A N   1 
ATOM   509  C CA  . VAL A 1 70  ? 3.413   -9.084  5.334   1.00 15.26 ? 95  VAL A CA  1 
ATOM   510  C C   . VAL A 1 70  ? 4.459   -7.988  5.170   1.00 11.11 ? 95  VAL A C   1 
ATOM   511  O O   . VAL A 1 70  ? 4.110   -6.815  5.000   1.00 13.81 ? 95  VAL A O   1 
ATOM   512  C CB  . VAL A 1 70  ? 2.712   -9.362  3.987   1.00 14.35 ? 95  VAL A CB  1 
ATOM   513  C CG1 . VAL A 1 70  ? 3.731   -9.712  2.927   1.00 14.93 ? 95  VAL A CG1 1 
ATOM   514  C CG2 . VAL A 1 70  ? 1.691   -10.484 4.137   1.00 13.61 ? 95  VAL A CG2 1 
ATOM   515  N N   . GLU A 1 71  ? 5.731   -8.369  5.240   1.00 12.89 ? 96  GLU A N   1 
ATOM   516  C CA  . GLU A 1 71  ? 6.821   -7.410  5.091   1.00 13.13 ? 96  GLU A CA  1 
ATOM   517  C C   . GLU A 1 71  ? 6.883   -6.836  3.678   1.00 12.08 ? 96  GLU A C   1 
ATOM   518  O O   . GLU A 1 71  ? 6.808   -7.565  2.685   1.00 13.75 ? 96  GLU A O   1 
ATOM   519  C CB  . GLU A 1 71  ? 8.163   -8.078  5.398   1.00 15.17 ? 96  GLU A CB  1 
ATOM   520  C CG  . GLU A 1 71  ? 8.342   -8.514  6.846   1.00 18.72 ? 96  GLU A CG  1 
ATOM   521  C CD  . GLU A 1 71  ? 9.726   -9.064  7.118   1.00 32.40 ? 96  GLU A CD  1 
ATOM   522  O OE1 . GLU A 1 71  ? 10.563  -9.051  6.190   1.00 34.25 ? 96  GLU A OE1 1 
ATOM   523  O OE2 . GLU A 1 71  ? 9.990   -9.466  8.271   1.00 34.97 ? 96  GLU A OE2 1 
ATOM   524  N N   . ILE A 1 72  ? 7.052   -5.516  3.597   1.00 11.06 ? 97  ILE A N   1 
ATOM   525  C CA  . ILE A 1 72  ? 7.294   -4.803  2.346   1.00 13.44 ? 97  ILE A CA  1 
ATOM   526  C C   . ILE A 1 72  ? 8.718   -4.262  2.390   1.00 13.66 ? 97  ILE A C   1 
ATOM   527  O O   . ILE A 1 72  ? 9.012   -3.342  3.165   1.00 12.43 ? 97  ILE A O   1 
ATOM   528  C CB  . ILE A 1 72  ? 6.310   -3.643  2.160   1.00 15.30 ? 97  ILE A CB  1 
ATOM   529  C CG1 . ILE A 1 72  ? 4.856   -4.070  2.443   1.00 12.35 ? 97  ILE A CG1 1 
ATOM   530  C CG2 . ILE A 1 72  ? 6.457   -3.069  0.771   1.00 13.72 ? 97  ILE A CG2 1 
ATOM   531  C CD1 . ILE A 1 72  ? 4.310   -5.142  1.520   1.00 16.03 ? 97  ILE A CD1 1 
ATOM   532  N N   . LYS A 1 73  ? 9.596   -4.788  1.533   1.00 13.23 ? 98  LYS A N   1 
ATOM   533  C CA  . LYS A 1 73  ? 10.995  -4.353  1.537   1.00 10.82 ? 98  LYS A CA  1 
ATOM   534  C C   . LYS A 1 73  ? 11.290  -3.502  0.309   1.00 11.33 ? 98  LYS A C   1 
ATOM   535  O O   . LYS A 1 73  ? 10.596  -3.618  -0.705  1.00 13.00 ? 98  LYS A O   1 
ATOM   536  C CB  . LYS A 1 73  ? 11.914  -5.576  1.484   1.00 13.57 ? 98  LYS A CB  1 
ATOM   537  C CG  . LYS A 1 73  ? 11.620  -6.648  2.508   1.00 20.60 ? 98  LYS A CG  1 
ATOM   538  C CD  . LYS A 1 73  ? 12.864  -7.459  2.826   1.00 31.04 ? 98  LYS A CD  1 
ATOM   539  C CE  . LYS A 1 73  ? 12.624  -8.405  3.987   1.00 37.55 ? 98  LYS A CE  1 
ATOM   540  N NZ  . LYS A 1 73  ? 13.890  -8.987  4.521   1.00 34.57 ? 98  LYS A NZ  1 
ATOM   541  N N   . PRO A 1 74  ? 12.298  -2.622  0.358   1.00 13.05 ? 99  PRO A N   1 
ATOM   542  C CA  . PRO A 1 74  ? 12.608  -1.816  -0.836  1.00 15.08 ? 99  PRO A CA  1 
ATOM   543  C C   . PRO A 1 74  ? 12.837  -2.636  -2.093  1.00 14.44 ? 99  PRO A C   1 
ATOM   544  O O   . PRO A 1 74  ? 12.463  -2.196  -3.191  1.00 15.36 ? 99  PRO A O   1 
ATOM   545  C CB  . PRO A 1 74  ? 13.856  -1.016  -0.432  1.00 17.83 ? 99  PRO A CB  1 
ATOM   546  C CG  . PRO A 1 74  ? 13.930  -1.101  1.051   1.00 17.82 ? 99  PRO A CG  1 
ATOM   547  C CD  . PRO A 1 74  ? 13.128  -2.267  1.526   1.00 12.72 ? 99  PRO A CD  1 
ATOM   548  N N   . ALA A 1 75  ? 13.437  -3.820  -1.967  1.00 13.31 ? 100 ALA A N   1 
ATOM   549  C CA  . ALA A 1 75  ? 13.704  -4.650  -3.135  1.00 12.92 ? 100 ALA A CA  1 
ATOM   550  C C   . ALA A 1 75  ? 12.428  -5.240  -3.732  1.00 19.18 ? 100 ALA A C   1 
ATOM   551  O O   . ALA A 1 75  ? 12.451  -5.715  -4.878  1.00 21.31 ? 100 ALA A O   1 
ATOM   552  C CB  . ALA A 1 75  ? 14.658  -5.782  -2.760  1.00 17.50 ? 100 ALA A CB  1 
ATOM   553  N N   . ASP A 1 76  ? 11.314  -5.215  -2.991  1.00 15.35 ? 101 ASP A N   1 
ATOM   554  C CA  . ASP A 1 76  ? 10.061  -5.766  -3.494  1.00 15.57 ? 101 ASP A CA  1 
ATOM   555  C C   . ASP A 1 76  ? 9.358   -4.829  -4.460  1.00 13.97 ? 101 ASP A C   1 
ATOM   556  O O   . ASP A 1 76  ? 8.449   -5.264  -5.176  1.00 15.59 ? 101 ASP A O   1 
ATOM   557  C CB  . ASP A 1 76  ? 9.086   -6.020  -2.342  1.00 12.24 ? 101 ASP A CB  1 
ATOM   558  C CG  . ASP A 1 76  ? 9.569   -7.067  -1.374  1.00 14.37 ? 101 ASP A CG  1 
ATOM   559  O OD1 . ASP A 1 76  ? 10.454  -7.867  -1.740  1.00 22.51 ? 101 ASP A OD1 1 
ATOM   560  O OD2 . ASP A 1 76  ? 9.051   -7.084  -0.234  1.00 18.90 ? 101 ASP A OD2 1 
ATOM   561  N N   . LEU A 1 77  ? 9.723   -3.548  -4.477  1.00 11.39 ? 102 LEU A N   1 
ATOM   562  C CA  . LEU A 1 77  ? 9.009   -2.595  -5.315  1.00 10.98 ? 102 LEU A CA  1 
ATOM   563  C C   . LEU A 1 77  ? 9.267   -2.877  -6.791  1.00 13.52 ? 102 LEU A C   1 
ATOM   564  O O   . LEU A 1 77  ? 10.391  -3.195  -7.191  1.00 15.32 ? 102 LEU A O   1 
ATOM   565  C CB  . LEU A 1 77  ? 9.451   -1.171  -4.976  1.00 12.24 ? 102 LEU A CB  1 
ATOM   566  C CG  . LEU A 1 77  ? 9.103   -0.711  -3.554  1.00 16.19 ? 102 LEU A CG  1 
ATOM   567  C CD1 . LEU A 1 77  ? 9.401   0.770   -3.408  1.00 17.67 ? 102 LEU A CD1 1 
ATOM   568  C CD2 . LEU A 1 77  ? 7.645   -1.018  -3.214  1.00 12.04 ? 102 LEU A CD2 1 
ATOM   569  N N   . VAL A 1 78  ? 8.214   -2.753  -7.603  1.00 14.87 ? 103 VAL A N   1 
ATOM   570  C CA  . VAL A 1 78  ? 8.301   -2.971  -9.049  1.00 12.11 ? 103 VAL A CA  1 
ATOM   571  C C   . VAL A 1 78  ? 7.985   -1.676  -9.798  1.00 12.09 ? 103 VAL A C   1 
ATOM   572  O O   . VAL A 1 78  ? 8.486   -0.615  -9.418  1.00 14.58 ? 103 VAL A O   1 
ATOM   573  C CB  . VAL A 1 78  ? 7.518   -4.211  -9.542  1.00 10.38 ? 103 VAL A CB  1 
ATOM   574  C CG1 . VAL A 1 78  ? 8.226   -5.476  -9.067  1.00 14.90 ? 103 VAL A CG1 1 
ATOM   575  C CG2 . VAL A 1 78  ? 6.081   -4.207  -9.064  1.00 14.13 ? 103 VAL A CG2 1 
ATOM   576  N N   . ASN A 1 79  ? 7.185   -1.740  -10.869 1.00 14.20 ? 104 ASN A N   1 
ATOM   577  C CA  . ASN A 1 79  ? 6.990   -0.584  -11.746 1.00 13.09 ? 104 ASN A CA  1 
ATOM   578  C C   . ASN A 1 79  ? 5.890   0.373   -11.301 1.00 14.30 ? 104 ASN A C   1 
ATOM   579  O O   . ASN A 1 79  ? 5.893   1.534   -11.731 1.00 19.30 ? 104 ASN A O   1 
ATOM   580  C CB  . ASN A 1 79  ? 6.673   -1.029  -13.174 1.00 13.54 ? 104 ASN A CB  1 
ATOM   581  C CG  . ASN A 1 79  ? 5.450   -1.906  -13.245 1.00 11.86 ? 104 ASN A CG  1 
ATOM   582  O OD1 . ASN A 1 79  ? 5.271   -2.807  -12.431 1.00 12.80 ? 104 ASN A OD1 1 
ATOM   583  N ND2 . ASN A 1 79  ? 4.578   -1.630  -14.206 1.00 19.31 ? 104 ASN A ND2 1 
ATOM   584  N N   . TYR A 1 80  ? 4.937   -0.069  -10.483 1.00 12.72 ? 105 TYR A N   1 
ATOM   585  C CA  . TYR A 1 80  ? 3.797   0.778   -10.116 1.00 8.85  ? 105 TYR A CA  1 
ATOM   586  C C   . TYR A 1 80  ? 3.320   0.343   -8.731  1.00 12.80 ? 105 TYR A C   1 
ATOM   587  O O   . TYR A 1 80  ? 2.641   -0.681  -8.595  1.00 13.61 ? 105 TYR A O   1 
ATOM   588  C CB  . TYR A 1 80  ? 2.682   0.678   -11.148 1.00 13.35 ? 105 TYR A CB  1 
ATOM   589  C CG  . TYR A 1 80  ? 1.575   1.659   -10.867 1.00 14.99 ? 105 TYR A CG  1 
ATOM   590  C CD1 . TYR A 1 80  ? 1.805   3.023   -10.977 1.00 16.28 ? 105 TYR A CD1 1 
ATOM   591  C CD2 . TYR A 1 80  ? 0.323   1.232   -10.440 1.00 15.32 ? 105 TYR A CD2 1 
ATOM   592  C CE1 . TYR A 1 80  ? 0.819   3.939   -10.718 1.00 14.99 ? 105 TYR A CE1 1 
ATOM   593  C CE2 . TYR A 1 80  ? -0.683  2.150   -10.154 1.00 13.33 ? 105 TYR A CE2 1 
ATOM   594  C CZ  . TYR A 1 80  ? -0.421  3.500   -10.301 1.00 17.69 ? 105 TYR A CZ  1 
ATOM   595  O OH  . TYR A 1 80  ? -1.387  4.429   -10.039 1.00 16.64 ? 105 TYR A OH  1 
ATOM   596  N N   . ASN A 1 81  ? 3.664   1.131   -7.713  1.00 12.62 ? 106 ASN A N   1 
ATOM   597  C CA  . ASN A 1 81  ? 3.503   0.735   -6.316  1.00 11.47 ? 106 ASN A CA  1 
ATOM   598  C C   . ASN A 1 81  ? 2.972   1.896   -5.482  1.00 15.24 ? 106 ASN A C   1 
ATOM   599  O O   . ASN A 1 81  ? 3.555   2.212   -4.438  1.00 13.65 ? 106 ASN A O   1 
ATOM   600  C CB  . ASN A 1 81  ? 4.870   0.332   -5.744  1.00 17.80 ? 106 ASN A CB  1 
ATOM   601  C CG  . ASN A 1 81  ? 5.803   -0.260  -6.795  1.00 13.85 ? 106 ASN A CG  1 
ATOM   602  O OD1 . ASN A 1 81  ? 5.603   -1.378  -7.274  1.00 15.07 ? 106 ASN A OD1 1 
ATOM   603  N ND2 . ASN A 1 81  ? 6.807   0.509   -7.185  1.00 17.71 ? 106 ASN A ND2 1 
ATOM   604  N N   . PRO A 1 82  ? 1.864   2.530   -5.874  1.00 11.45 ? 107 PRO A N   1 
ATOM   605  C CA  . PRO A 1 82  ? 1.435   3.746   -5.161  1.00 11.49 ? 107 PRO A CA  1 
ATOM   606  C C   . PRO A 1 82  ? 1.168   3.529   -3.686  1.00 16.32 ? 107 PRO A C   1 
ATOM   607  O O   . PRO A 1 82  ? 1.423   4.432   -2.880  1.00 19.33 ? 107 PRO A O   1 
ATOM   608  C CB  . PRO A 1 82  ? 0.169   4.169   -5.916  1.00 15.87 ? 107 PRO A CB  1 
ATOM   609  C CG  . PRO A 1 82  ? -0.365  2.900   -6.499  1.00 16.08 ? 107 PRO A CG  1 
ATOM   610  C CD  . PRO A 1 82  ? 0.868   2.094   -6.866  1.00 13.07 ? 107 PRO A CD  1 
ATOM   611  N N   . ILE A 1 83  ? 0.676   2.359   -3.295  1.00 12.04 ? 108 ILE A N   1 
ATOM   612  C CA  . ILE A 1 83  ? 0.380   2.099   -1.889  1.00 12.07 ? 108 ILE A CA  1 
ATOM   613  C C   . ILE A 1 83  ? 1.561   1.466   -1.189  1.00 13.08 ? 108 ILE A C   1 
ATOM   614  O O   . ILE A 1 83  ? 1.961   1.875   -0.094  1.00 10.75 ? 108 ILE A O   1 
ATOM   615  C CB  . ILE A 1 83  ? -0.883  1.230   -1.746  1.00 10.49 ? 108 ILE A CB  1 
ATOM   616  C CG1 . ILE A 1 83  ? -2.033  1.781   -2.604  1.00 12.10 ? 108 ILE A CG1 1 
ATOM   617  C CG2 . ILE A 1 83  ? -1.271  1.111   -0.287  1.00 12.44 ? 108 ILE A CG2 1 
ATOM   618  C CD1 . ILE A 1 83  ? -2.431  3.261   -2.334  1.00 12.86 ? 108 ILE A CD1 1 
ATOM   619  N N   . ALA A 1 84  ? 2.150   0.449   -1.813  1.00 10.49 ? 109 ALA A N   1 
ATOM   620  C CA  . ALA A 1 84  ? 3.236   -0.258  -1.156  1.00 9.04  ? 109 ALA A CA  1 
ATOM   621  C C   . ALA A 1 84  ? 4.421   0.650   -0.849  1.00 13.02 ? 109 ALA A C   1 
ATOM   622  O O   . ALA A 1 84  ? 5.098   0.440   0.162   1.00 12.18 ? 109 ALA A O   1 
ATOM   623  C CB  . ALA A 1 84  ? 3.661   -1.455  -2.008  1.00 13.23 ? 109 ALA A CB  1 
ATOM   624  N N   A GLU A 1 85  ? 4.685   1.667   -1.680  0.52 11.21 ? 110 GLU A N   1 
ATOM   625  N N   B GLU A 1 85  ? 4.666   1.666   -1.689  0.48 11.22 ? 110 GLU A N   1 
ATOM   626  C CA  A GLU A 1 85  ? 5.818   2.547   -1.393  0.52 15.00 ? 110 GLU A CA  1 
ATOM   627  C CA  B GLU A 1 85  ? 5.762   2.604   -1.448  0.48 15.00 ? 110 GLU A CA  1 
ATOM   628  C C   A GLU A 1 85  ? 5.625   3.344   -0.108  0.52 16.66 ? 110 GLU A C   1 
ATOM   629  C C   B GLU A 1 85  ? 5.617   3.314   -0.109  0.48 16.63 ? 110 GLU A C   1 
ATOM   630  O O   A GLU A 1 85  ? 6.613   3.805   0.476   0.52 17.56 ? 110 GLU A O   1 
ATOM   631  O O   B GLU A 1 85  ? 6.620   3.682   0.513   0.48 17.54 ? 110 GLU A O   1 
ATOM   632  C CB  A GLU A 1 85  ? 6.129   3.494   -2.557  0.52 17.07 ? 110 GLU A CB  1 
ATOM   633  C CB  B GLU A 1 85  ? 5.837   3.633   -2.579  0.48 16.65 ? 110 GLU A CB  1 
ATOM   634  C CG  A GLU A 1 85  ? 5.070   4.536   -2.830  0.52 13.92 ? 110 GLU A CG  1 
ATOM   635  C CG  B GLU A 1 85  ? 6.935   3.348   -3.590  0.48 18.70 ? 110 GLU A CG  1 
ATOM   636  C CD  A GLU A 1 85  ? 5.307   5.281   -4.140  0.52 19.65 ? 110 GLU A CD  1 
ATOM   637  C CD  B GLU A 1 85  ? 6.627   3.881   -4.979  0.48 18.97 ? 110 GLU A CD  1 
ATOM   638  O OE1 A GLU A 1 85  ? 6.300   4.969   -4.833  0.52 24.68 ? 110 GLU A OE1 1 
ATOM   639  O OE1 B GLU A 1 85  ? 5.990   4.952   -5.083  0.48 24.93 ? 110 GLU A OE1 1 
ATOM   640  O OE2 A GLU A 1 85  ? 4.491   6.164   -4.483  0.52 24.65 ? 110 GLU A OE2 1 
ATOM   641  O OE2 B GLU A 1 85  ? 7.037   3.232   -5.968  0.48 16.72 ? 110 GLU A OE2 1 
ATOM   642  N N   . LYS A 1 86  ? 4.385   3.515   0.352   1.00 13.25 ? 111 LYS A N   1 
ATOM   643  C CA  . LYS A 1 86  ? 4.166   4.198   1.621   1.00 15.58 ? 111 LYS A CA  1 
ATOM   644  C C   . LYS A 1 86  ? 4.530   3.329   2.813   1.00 16.20 ? 111 LYS A C   1 
ATOM   645  O O   . LYS A 1 86  ? 4.782   3.863   3.901   1.00 15.42 ? 111 LYS A O   1 
ATOM   646  C CB  . LYS A 1 86  ? 2.704   4.640   1.729   1.00 20.87 ? 111 LYS A CB  1 
ATOM   647  C CG  . LYS A 1 86  ? 2.308   5.672   0.691   0.73 19.28 ? 111 LYS A CG  1 
ATOM   648  C CD  . LYS A 1 86  ? 0.873   6.124   0.865   0.50 23.88 ? 111 LYS A CD  1 
ATOM   649  C CE  . LYS A 1 86  ? 0.086   5.934   -0.423  0.59 21.69 ? 111 LYS A CE  1 
ATOM   650  N NZ  . LYS A 1 86  ? -1.386  5.969   -0.207  1.00 32.51 ? 111 LYS A NZ  1 
ATOM   651  N N   . HIS A 1 87  ? 4.577   2.006   2.629   1.00 13.51 ? 112 HIS A N   1 
ATOM   652  C CA  . HIS A 1 87  ? 4.774   1.064   3.722   1.00 12.13 ? 112 HIS A CA  1 
ATOM   653  C C   . HIS A 1 87  ? 6.075   0.288   3.610   1.00 12.57 ? 112 HIS A C   1 
ATOM   654  O O   . HIS A 1 87  ? 6.275   -0.678  4.363   1.00 14.49 ? 112 HIS A O   1 
ATOM   655  C CB  . HIS A 1 87  ? 3.578   0.114   3.791   1.00 13.19 ? 112 HIS A CB  1 
ATOM   656  C CG  . HIS A 1 87  ? 2.285   0.838   3.941   1.00 14.98 ? 112 HIS A CG  1 
ATOM   657  N ND1 . HIS A 1 87  ? 1.856   1.333   5.154   1.00 24.90 ? 112 HIS A ND1 1 
ATOM   658  C CD2 . HIS A 1 87  ? 1.364   1.225   3.028   1.00 13.60 ? 112 HIS A CD2 1 
ATOM   659  C CE1 . HIS A 1 87  ? 0.709   1.966   4.986   1.00 24.78 ? 112 HIS A CE1 1 
ATOM   660  N NE2 . HIS A 1 87  ? 0.390   1.916   3.705   1.00 19.71 ? 112 HIS A NE2 1 
ATOM   661  N N   . VAL A 1 88  ? 6.974   0.678   2.703   1.00 12.63 ? 113 VAL A N   1 
ATOM   662  C CA  . VAL A 1 88  ? 8.273   0.019   2.647   1.00 12.00 ? 113 VAL A CA  1 
ATOM   663  C C   . VAL A 1 88  ? 8.972   0.110   4.003   1.00 14.85 ? 113 VAL A C   1 
ATOM   664  O O   . VAL A 1 88  ? 8.834   1.091   4.746   1.00 13.25 ? 113 VAL A O   1 
ATOM   665  C CB  . VAL A 1 88  ? 9.169   0.608   1.543   1.00 15.59 ? 113 VAL A CB  1 
ATOM   666  C CG1 . VAL A 1 88  ? 8.690   0.184   0.179   1.00 18.97 ? 113 VAL A CG1 1 
ATOM   667  C CG2 . VAL A 1 88  ? 9.217   2.110   1.664   1.00 19.59 ? 113 VAL A CG2 1 
ATOM   668  N N   . ASN A 1 89  ? 9.749   -0.923  4.314   1.00 11.11 ? 114 ASN A N   1 
ATOM   669  C CA  . ASN A 1 89  ? 10.411  -1.098  5.611   1.00 11.84 ? 114 ASN A CA  1 
ATOM   670  C C   . ASN A 1 89  ? 9.424   -1.279  6.762   1.00 14.54 ? 114 ASN A C   1 
ATOM   671  O O   . ASN A 1 89  ? 9.797   -1.146  7.934   1.00 17.12 ? 114 ASN A O   1 
ATOM   672  C CB  . ASN A 1 89  ? 11.498  -0.054  5.914   1.00 10.61 ? 114 ASN A CB  1 
ATOM   673  C CG  . ASN A 1 89  ? 12.639  -0.093  4.904   1.00 10.68 ? 114 ASN A CG  1 
ATOM   674  O OD1 . ASN A 1 89  ? 13.242  -1.153  4.698   1.00 15.34 ? 114 ASN A OD1 1 
ATOM   675  N ND2 . ASN A 1 89  ? 12.976  1.060   4.311   1.00 9.07  ? 114 ASN A ND2 1 
ATOM   676  N N   . GLY A 1 90  ? 8.182   -1.618  6.437   1.00 12.94 ? 115 GLY A N   1 
ATOM   677  C CA  . GLY A 1 90  ? 7.190   -2.020  7.414   1.00 13.16 ? 115 GLY A CA  1 
ATOM   678  C C   . GLY A 1 90  ? 6.349   -3.160  6.871   1.00 11.58 ? 115 GLY A C   1 
ATOM   679  O O   . GLY A 1 90  ? 6.826   -3.946  6.050   1.00 12.58 ? 115 GLY A O   1 
ATOM   680  N N   . THR A 1 91  ? 5.083   -3.232  7.280   1.00 14.07 ? 116 THR A N   1 
ATOM   681  C CA  . THR A 1 91  ? 4.199   -4.312  6.874   1.00 11.87 ? 116 THR A CA  1 
ATOM   682  C C   . THR A 1 91  ? 2.849   -3.771  6.408   1.00 14.68 ? 116 THR A C   1 
ATOM   683  O O   . THR A 1 91  ? 2.465   -2.624  6.680   1.00 15.10 ? 116 THR A O   1 
ATOM   684  C CB  . THR A 1 91  ? 3.973   -5.316  8.014   1.00 18.56 ? 116 THR A CB  1 
ATOM   685  O OG1 . THR A 1 91  ? 3.362   -4.645  9.120   1.00 16.58 ? 116 THR A OG1 1 
ATOM   686  C CG2 . THR A 1 91  ? 5.294   -5.950  8.460   1.00 16.93 ? 116 THR A CG2 1 
ATOM   687  N N   . MET A 1 92  ? 2.124   -4.640  5.697   1.00 11.90 ? 117 MET A N   1 
ATOM   688  C CA  . MET A 1 92  ? 0.779   -4.375  5.211   1.00 14.17 ? 117 MET A CA  1 
ATOM   689  C C   . MET A 1 92  ? 0.043   -5.685  5.444   1.00 9.08  ? 117 MET A C   1 
ATOM   690  O O   . MET A 1 92  ? 0.656   -6.748  5.338   1.00 11.64 ? 117 MET A O   1 
ATOM   691  C CB  . MET A 1 92  ? 0.933   -4.119  3.716   1.00 15.04 ? 117 MET A CB  1 
ATOM   692  C CG  . MET A 1 92  ? 1.239   -2.669  3.386   1.00 13.61 ? 117 MET A CG  1 
ATOM   693  S SD  . MET A 1 92  ? 1.179   -2.334  1.615   1.00 13.43 ? 117 MET A SD  1 
ATOM   694  C CE  . MET A 1 92  ? -0.578  -2.236  1.267   1.00 14.40 ? 117 MET A CE  1 
ATOM   695  N N   . THR A 1 93  ? -1.237  -5.630  5.826   1.00 11.76 ? 118 THR A N   1 
ATOM   696  C CA  . THR A 1 93  ? -1.958  -6.890  5.982   1.00 11.46 ? 118 THR A CA  1 
ATOM   697  C C   . THR A 1 93  ? -2.451  -7.400  4.630   1.00 10.31 ? 118 THR A C   1 
ATOM   698  O O   . THR A 1 93  ? -2.475  -6.675  3.637   1.00 11.26 ? 118 THR A O   1 
ATOM   699  C CB  . THR A 1 93  ? -3.169  -6.747  6.908   1.00 9.87  ? 118 THR A CB  1 
ATOM   700  O OG1 . THR A 1 93  ? -4.127  -5.900  6.268   1.00 10.17 ? 118 THR A OG1 1 
ATOM   701  C CG2 . THR A 1 93  ? -2.773  -6.153  8.244   1.00 13.20 ? 118 THR A CG2 1 
ATOM   702  N N   . LEU A 1 94  ? -2.812  -8.689  4.592   1.00 10.74 ? 119 LEU A N   1 
ATOM   703  C CA  . LEU A 1 94  ? -3.334  -9.256  3.353   1.00 10.83 ? 119 LEU A CA  1 
ATOM   704  C C   . LEU A 1 94  ? -4.607  -8.567  2.888   1.00 10.25 ? 119 LEU A C   1 
ATOM   705  O O   . LEU A 1 94  ? -4.818  -8.426  1.676   1.00 9.14  ? 119 LEU A O   1 
ATOM   706  C CB  . LEU A 1 94  ? -3.529  -10.759 3.490   1.00 10.27 ? 119 LEU A CB  1 
ATOM   707  C CG  . LEU A 1 94  ? -2.198  -11.501 3.329   1.00 11.19 ? 119 LEU A CG  1 
ATOM   708  C CD1 . LEU A 1 94  ? -2.341  -12.936 3.811   1.00 20.93 ? 119 LEU A CD1 1 
ATOM   709  C CD2 . LEU A 1 94  ? -1.702  -11.452 1.893   1.00 11.47 ? 119 LEU A CD2 1 
ATOM   710  N N   . ALA A 1 95  ? -5.457  -8.116  3.820   1.00 10.24 ? 120 ALA A N   1 
ATOM   711  C CA  . ALA A 1 95  ? -6.601  -7.294  3.433   1.00 9.49  ? 120 ALA A CA  1 
ATOM   712  C C   . ALA A 1 95  ? -6.163  -5.976  2.804   1.00 10.92 ? 120 ALA A C   1 
ATOM   713  O O   . ALA A 1 95  ? -6.705  -5.566  1.771   1.00 11.72 ? 120 ALA A O   1 
ATOM   714  C CB  . ALA A 1 95  ? -7.503  -7.026  4.640   1.00 11.71 ? 120 ALA A CB  1 
ATOM   715  N N   . GLU A 1 96  ? -5.182  -5.301  3.407   1.00 11.55 ? 121 GLU A N   1 
ATOM   716  C CA  . GLU A 1 96  ? -4.695  -4.046  2.840   1.00 9.92  ? 121 GLU A CA  1 
ATOM   717  C C   . GLU A 1 96  ? -4.053  -4.261  1.481   1.00 10.68 ? 121 GLU A C   1 
ATOM   718  O O   . GLU A 1 96  ? -4.169  -3.399  0.599   1.00 12.20 ? 121 GLU A O   1 
ATOM   719  C CB  . GLU A 1 96  ? -3.754  -3.356  3.825   1.00 10.49 ? 121 GLU A CB  1 
ATOM   720  C CG  . GLU A 1 96  ? -4.471  -2.948  5.112   1.00 11.97 ? 121 GLU A CG  1 
ATOM   721  C CD  . GLU A 1 96  ? -3.531  -2.626  6.269   1.00 16.49 ? 121 GLU A CD  1 
ATOM   722  O OE1 . GLU A 1 96  ? -2.326  -2.938  6.179   1.00 13.58 ? 121 GLU A OE1 1 
ATOM   723  O OE2 . GLU A 1 96  ? -4.027  -2.101  7.295   1.00 22.36 ? 121 GLU A OE2 1 
ATOM   724  N N   . LEU A 1 97  ? -3.380  -5.400  1.291   1.00 11.06 ? 122 LEU A N   1 
ATOM   725  C CA  . LEU A 1 97  ? -2.762  -5.693  0.003   1.00 10.78 ? 122 LEU A CA  1 
ATOM   726  C C   . LEU A 1 97  ? -3.819  -5.997  -1.047  1.00 10.35 ? 122 LEU A C   1 
ATOM   727  O O   . LEU A 1 97  ? -3.688  -5.594  -2.207  1.00 9.11  ? 122 LEU A O   1 
ATOM   728  C CB  . LEU A 1 97  ? -1.787  -6.864  0.152   1.00 9.03  ? 122 LEU A CB  1 
ATOM   729  C CG  . LEU A 1 97  ? -0.533  -6.469  0.945   1.00 9.03  ? 122 LEU A CG  1 
ATOM   730  C CD1 . LEU A 1 97  ? 0.105   -7.643  1.655   1.00 10.39 ? 122 LEU A CD1 1 
ATOM   731  C CD2 . LEU A 1 97  ? 0.466   -5.800  0.044   1.00 9.36  ? 122 LEU A CD2 1 
ATOM   732  N N   . SER A 1 98  ? -4.864  -6.734  -0.665  1.00 10.95 ? 123 SER A N   1 
ATOM   733  C CA  . SER A 1 98  ? -5.956  -7.010  -1.596  1.00 9.85  ? 123 SER A CA  1 
ATOM   734  C C   . SER A 1 98  ? -6.628  -5.721  -2.051  1.00 10.50 ? 123 SER A C   1 
ATOM   735  O O   . SER A 1 98  ? -6.863  -5.516  -3.247  1.00 10.78 ? 123 SER A O   1 
ATOM   736  C CB  . SER A 1 98  ? -6.974  -7.940  -0.940  1.00 10.52 ? 123 SER A CB  1 
ATOM   737  O OG  . SER A 1 98  ? -6.400  -9.190  -0.574  1.00 10.12 ? 123 SER A OG  1 
ATOM   738  N N   . ALA A 1 99  ? -6.927  -4.819  -1.105  1.00 10.76 ? 124 ALA A N   1 
ATOM   739  C CA  . ALA A 1 99  ? -7.556  -3.553  -1.459  1.00 8.90  ? 124 ALA A CA  1 
ATOM   740  C C   . ALA A 1 99  ? -6.637  -2.695  -2.320  1.00 10.59 ? 124 ALA A C   1 
ATOM   741  O O   . ALA A 1 99  ? -7.089  -2.053  -3.272  1.00 11.42 ? 124 ALA A O   1 
ATOM   742  C CB  . ALA A 1 99  ? -7.970  -2.791  -0.194  1.00 12.48 ? 124 ALA A CB  1 
ATOM   743  N N   . ALA A 1 100 ? -5.338  -2.675  -2.006  1.00 10.66 ? 125 ALA A N   1 
ATOM   744  C CA  . ALA A 1 100 ? -4.401  -1.911  -2.826  1.00 9.91  ? 125 ALA A CA  1 
ATOM   745  C C   . ALA A 1 100 ? -4.311  -2.472  -4.242  1.00 10.50 ? 125 ALA A C   1 
ATOM   746  O O   . ALA A 1 100 ? -4.298  -1.712  -5.216  1.00 11.41 ? 125 ALA A O   1 
ATOM   747  C CB  . ALA A 1 100 ? -3.025  -1.871  -2.154  1.00 9.85  ? 125 ALA A CB  1 
ATOM   748  N N   . ALA A 1 101 ? -4.249  -3.799  -4.373  1.00 10.61 ? 126 ALA A N   1 
ATOM   749  C CA  . ALA A 1 101 ? -4.189  -4.416  -5.697  1.00 8.75  ? 126 ALA A CA  1 
ATOM   750  C C   . ALA A 1 101 ? -5.445  -4.126  -6.506  1.00 9.99  ? 126 ALA A C   1 
ATOM   751  O O   . ALA A 1 101 ? -5.360  -3.844  -7.705  1.00 10.45 ? 126 ALA A O   1 
ATOM   752  C CB  . ALA A 1 101 ? -3.979  -5.927  -5.566  1.00 9.99  ? 126 ALA A CB  1 
ATOM   753  N N   . LEU A 1 102 ? -6.621  -4.188  -5.870  1.00 10.36 ? 127 LEU A N   1 
ATOM   754  C CA  . LEU A 1 102 ? -7.859  -4.013  -6.624  1.00 10.64 ? 127 LEU A CA  1 
ATOM   755  C C   . LEU A 1 102 ? -8.177  -2.550  -6.889  1.00 8.71  ? 127 LEU A C   1 
ATOM   756  O O   . LEU A 1 102 ? -8.549  -2.184  -8.009  1.00 9.72  ? 127 LEU A O   1 
ATOM   757  C CB  . LEU A 1 102 ? -9.019  -4.682  -5.891  1.00 9.93  ? 127 LEU A CB  1 
ATOM   758  C CG  . LEU A 1 102 ? -8.987  -6.209  -5.896  1.00 9.88  ? 127 LEU A CG  1 
ATOM   759  C CD1 . LEU A 1 102 ? -10.194 -6.709  -5.146  1.00 11.07 ? 127 LEU A CD1 1 
ATOM   760  C CD2 . LEU A 1 102 ? -8.960  -6.733  -7.333  1.00 10.82 ? 127 LEU A CD2 1 
ATOM   761  N N   . GLN A 1 103 ? -8.057  -1.694  -5.871  1.00 9.29  ? 128 GLN A N   1 
ATOM   762  C CA  . GLN A 1 103 ? -8.611  -0.355  -6.022  1.00 8.43  ? 128 GLN A CA  1 
ATOM   763  C C   . GLN A 1 103 ? -7.609  0.658   -6.537  1.00 8.39  ? 128 GLN A C   1 
ATOM   764  O O   . GLN A 1 103 ? -8.019  1.682   -7.074  1.00 10.74 ? 128 GLN A O   1 
ATOM   765  C CB  . GLN A 1 103 ? -9.201  0.127   -4.707  1.00 10.67 ? 128 GLN A CB  1 
ATOM   766  C CG  . GLN A 1 103 ? -10.231 -0.831  -4.125  1.00 10.57 ? 128 GLN A CG  1 
ATOM   767  C CD  . GLN A 1 103 ? -10.952 -0.239  -2.940  1.00 10.60 ? 128 GLN A CD  1 
ATOM   768  O OE1 . GLN A 1 103 ? -10.325 0.373   -2.067  1.00 15.41 ? 128 GLN A OE1 1 
ATOM   769  N NE2 . GLN A 1 103 ? -12.252 -0.484  -2.849  1.00 9.46  ? 128 GLN A NE2 1 
ATOM   770  N N   . TYR A 1 104 ? -6.319  0.401   -6.369  1.00 8.80  ? 129 TYR A N   1 
ATOM   771  C CA  . TYR A 1 104 ? -5.264  1.270   -6.867  1.00 11.01 ? 129 TYR A CA  1 
ATOM   772  C C   . TYR A 1 104 ? -4.393  0.575   -7.899  1.00 12.39 ? 129 TYR A C   1 
ATOM   773  O O   . TYR A 1 104 ? -3.481  1.203   -8.453  1.00 12.62 ? 129 TYR A O   1 
ATOM   774  C CB  . TYR A 1 104 ? -4.401  1.777   -5.702  1.00 11.47 ? 129 TYR A CB  1 
ATOM   775  C CG  . TYR A 1 104 ? -5.195  2.664   -4.768  1.00 11.49 ? 129 TYR A CG  1 
ATOM   776  C CD1 . TYR A 1 104 ? -5.935  2.117   -3.734  1.00 11.91 ? 129 TYR A CD1 1 
ATOM   777  C CD2 . TYR A 1 104 ? -5.264  4.028   -4.974  1.00 12.44 ? 129 TYR A CD2 1 
ATOM   778  C CE1 . TYR A 1 104 ? -6.692  2.904   -2.894  1.00 13.12 ? 129 TYR A CE1 1 
ATOM   779  C CE2 . TYR A 1 104 ? -6.014  4.842   -4.125  1.00 13.31 ? 129 TYR A CE2 1 
ATOM   780  C CZ  . TYR A 1 104 ? -6.727  4.267   -3.092  1.00 13.09 ? 129 TYR A CZ  1 
ATOM   781  O OH  . TYR A 1 104 ? -7.487  5.062   -2.252  1.00 14.99 ? 129 TYR A OH  1 
ATOM   782  N N   . SER A 1 105 ? -4.632  -0.706  -8.162  1.00 9.45  ? 130 SER A N   1 
ATOM   783  C CA  . SER A 1 105 ? -3.814  -1.475  -9.105  1.00 11.44 ? 130 SER A CA  1 
ATOM   784  C C   . SER A 1 105 ? -2.336  -1.463  -8.732  1.00 11.11 ? 130 SER A C   1 
ATOM   785  O O   . SER A 1 105 ? -1.463  -1.326  -9.591  1.00 12.00 ? 130 SER A O   1 
ATOM   786  C CB  . SER A 1 105 ? -4.024  -1.073  -10.567 1.00 12.54 ? 130 SER A CB  1 
ATOM   787  O OG  . SER A 1 105 ? -3.973  -2.228  -11.381 1.00 10.91 ? 130 SER A OG  1 
ATOM   788  N N   . ASP A 1 106 ? -2.065  -1.636  -7.441  1.00 10.59 ? 131 ASP A N   1 
ATOM   789  C CA  . ASP A 1 106 ? -0.691  -1.721  -6.963  1.00 10.29 ? 131 ASP A CA  1 
ATOM   790  C C   . ASP A 1 106 ? -0.068  -3.068  -7.343  1.00 9.52  ? 131 ASP A C   1 
ATOM   791  O O   . ASP A 1 106 ? -0.548  -4.129  -6.922  1.00 9.78  ? 131 ASP A O   1 
ATOM   792  C CB  . ASP A 1 106 ? -0.665  -1.512  -5.448  1.00 8.98  ? 131 ASP A CB  1 
ATOM   793  C CG  . ASP A 1 106 ? 0.748   -1.340  -4.898  1.00 10.81 ? 131 ASP A CG  1 
ATOM   794  O OD1 . ASP A 1 106 ? 1.599   -2.232  -5.077  1.00 10.64 ? 131 ASP A OD1 1 
ATOM   795  O OD2 . ASP A 1 106 ? 1.034   -0.291  -4.295  1.00 13.13 ? 131 ASP A OD2 1 
ATOM   796  N N   . ASN A 1 107 ? 1.022   -3.021  -8.120  1.00 9.32  ? 132 ASN A N   1 
ATOM   797  C CA  . ASN A 1 107 ? 1.658   -4.247  -8.599  1.00 11.02 ? 132 ASN A CA  1 
ATOM   798  C C   . ASN A 1 107 ? 2.477   -4.946  -7.521  1.00 11.54 ? 132 ASN A C   1 
ATOM   799  O O   . ASN A 1 107 ? 2.610   -6.172  -7.558  1.00 10.61 ? 132 ASN A O   1 
ATOM   800  C CB  . ASN A 1 107 ? 2.561   -3.965  -9.797  1.00 10.86 ? 132 ASN A CB  1 
ATOM   801  C CG  . ASN A 1 107 ? 1.812   -3.980  -11.113 1.00 10.39 ? 132 ASN A CG  1 
ATOM   802  O OD1 . ASN A 1 107 ? 0.650   -4.376  -11.183 1.00 12.01 ? 132 ASN A OD1 1 
ATOM   803  N ND2 . ASN A 1 107 ? 2.495   -3.572  -12.176 1.00 11.61 ? 132 ASN A ND2 1 
ATOM   804  N N   . THR A 1 108 ? 3.047   -4.214  -6.564  1.00 8.76  ? 133 THR A N   1 
ATOM   805  C CA  . THR A 1 108 ? 3.713   -4.896  -5.458  1.00 11.83 ? 133 THR A CA  1 
ATOM   806  C C   . THR A 1 108 ? 2.694   -5.639  -4.610  1.00 9.73  ? 133 THR A C   1 
ATOM   807  O O   . THR A 1 108 ? 2.933   -6.775  -4.184  1.00 10.30 ? 133 THR A O   1 
ATOM   808  C CB  . THR A 1 108 ? 4.517   -3.907  -4.611  1.00 12.92 ? 133 THR A CB  1 
ATOM   809  O OG1 . THR A 1 108 ? 5.563   -3.340  -5.402  1.00 12.94 ? 133 THR A OG1 1 
ATOM   810  C CG2 . THR A 1 108 ? 5.140   -4.598  -3.397  1.00 15.17 ? 133 THR A CG2 1 
ATOM   811  N N   . ALA A 1 109 ? 1.543   -5.020  -4.362  1.00 8.29  ? 134 ALA A N   1 
ATOM   812  C CA  . ALA A 1 109 ? 0.487   -5.721  -3.635  1.00 8.67  ? 134 ALA A CA  1 
ATOM   813  C C   . ALA A 1 109 ? 0.079   -6.996  -4.360  1.00 8.24  ? 134 ALA A C   1 
ATOM   814  O O   . ALA A 1 109 ? -0.049  -8.057  -3.734  1.00 10.36 ? 134 ALA A O   1 
ATOM   815  C CB  . ALA A 1 109 ? -0.722  -4.802  -3.436  1.00 11.56 ? 134 ALA A CB  1 
ATOM   816  N N   . MET A 1 110 ? -0.150  -6.909  -5.678  1.00 10.16 ? 135 MET A N   1 
ATOM   817  C CA  . MET A 1 110 ? -0.360  -8.111  -6.493  1.00 8.05  ? 135 MET A CA  1 
ATOM   818  C C   . MET A 1 110 ? 0.669   -9.198  -6.244  1.00 6.55  ? 135 MET A C   1 
ATOM   819  O O   . MET A 1 110 ? 0.311   -10.367 -6.040  1.00 8.38  ? 135 MET A O   1 
ATOM   820  C CB  . MET A 1 110 ? -0.471  -7.770  -7.977  1.00 11.24 ? 135 MET A CB  1 
ATOM   821  C CG  . MET A 1 110 ? -0.865  -8.934  -8.906  1.00 11.46 ? 135 MET A CG  1 
ATOM   822  S SD  . MET A 1 110 ? -2.121  -10.122 -8.471  1.00 10.75 ? 135 MET A SD  1 
ATOM   823  C CE  . MET A 1 110 ? -2.182  -11.088 -9.982  1.00 14.18 ? 135 MET A CE  1 
ATOM   824  N N   . ASN A 1 111 ? 1.953   -8.850  -6.269  1.00 10.44 ? 136 ASN A N   1 
ATOM   825  C CA  . ASN A 1 111 ? 2.965   -9.879  -6.069  1.00 8.77  ? 136 ASN A CA  1 
ATOM   826  C C   . ASN A 1 111 ? 2.853   -10.511 -4.688  1.00 10.56 ? 136 ASN A C   1 
ATOM   827  O O   . ASN A 1 111 ? 3.115   -11.708 -4.539  1.00 11.74 ? 136 ASN A O   1 
ATOM   828  C CB  . ASN A 1 111 ? 4.366   -9.315  -6.318  1.00 8.94  ? 136 ASN A CB  1 
ATOM   829  C CG  . ASN A 1 111 ? 4.712   -9.249  -7.792  1.00 10.37 ? 136 ASN A CG  1 
ATOM   830  O OD1 . ASN A 1 111 ? 4.005   -9.820  -8.629  1.00 13.43 ? 136 ASN A OD1 1 
ATOM   831  N ND2 . ASN A 1 111 ? 5.791   -8.543  -8.126  1.00 12.67 ? 136 ASN A ND2 1 
ATOM   832  N N   . LYS A 1 112 ? 2.454   -9.744  -3.666  1.00 9.62  ? 137 LYS A N   1 
ATOM   833  C CA  . LYS A 1 112 ? 2.279   -10.363 -2.355  1.00 8.50  ? 137 LYS A CA  1 
ATOM   834  C C   . LYS A 1 112 ? 1.087   -11.309 -2.347  1.00 10.31 ? 137 LYS A C   1 
ATOM   835  O O   . LYS A 1 112 ? 1.121   -12.337 -1.656  1.00 13.03 ? 137 LYS A O   1 
ATOM   836  C CB  . LYS A 1 112 ? 2.150   -9.296  -1.255  1.00 9.22  ? 137 LYS A CB  1 
ATOM   837  C CG  . LYS A 1 112 ? 3.365   -8.399  -1.067  1.00 9.89  ? 137 LYS A CG  1 
ATOM   838  C CD  . LYS A 1 112 ? 4.637   -9.194  -0.899  1.00 10.55 ? 137 LYS A CD  1 
ATOM   839  C CE  . LYS A 1 112 ? 5.774   -8.252  -0.535  1.00 14.26 ? 137 LYS A CE  1 
ATOM   840  N NZ  . LYS A 1 112 ? 7.067   -8.974  -0.344  1.00 16.63 ? 137 LYS A NZ  1 
ATOM   841  N N   . LEU A 1 113 ? 0.035   -11.000 -3.115  1.00 9.66  ? 138 LEU A N   1 
ATOM   842  C CA  . LEU A 1 113 ? -1.088  -11.932 -3.202  1.00 10.58 ? 138 LEU A CA  1 
ATOM   843  C C   . LEU A 1 113 ? -0.644  -13.221 -3.874  1.00 11.86 ? 138 LEU A C   1 
ATOM   844  O O   . LEU A 1 113 ? -0.931  -14.320 -3.388  1.00 9.62  ? 138 LEU A O   1 
ATOM   845  C CB  . LEU A 1 113 ? -2.243  -11.307 -3.985  1.00 12.00 ? 138 LEU A CB  1 
ATOM   846  C CG  . LEU A 1 113 ? -2.848  -10.019 -3.442  1.00 8.27  ? 138 LEU A CG  1 
ATOM   847  C CD1 . LEU A 1 113 ? -3.996  -9.604  -4.337  1.00 8.98  ? 138 LEU A CD1 1 
ATOM   848  C CD2 . LEU A 1 113 ? -3.324  -10.237 -2.009  1.00 12.16 ? 138 LEU A CD2 1 
ATOM   849  N N   . ILE A 1 114 ? 0.076   -13.091 -4.992  1.00 10.65 ? 139 ILE A N   1 
ATOM   850  C CA  . ILE A 1 114 ? 0.616   -14.251 -5.696  1.00 9.76  ? 139 ILE A CA  1 
ATOM   851  C C   . ILE A 1 114 ? 1.501   -15.084 -4.775  1.00 9.64  ? 139 ILE A C   1 
ATOM   852  O O   . ILE A 1 114 ? 1.413   -16.316 -4.759  1.00 10.91 ? 139 ILE A O   1 
ATOM   853  C CB  . ILE A 1 114 ? 1.367   -13.793 -6.959  1.00 8.82  ? 139 ILE A CB  1 
ATOM   854  C CG1 . ILE A 1 114 ? 0.408   -13.133 -7.962  1.00 9.59  ? 139 ILE A CG1 1 
ATOM   855  C CG2 . ILE A 1 114 ? 2.087   -14.990 -7.580  1.00 10.51 ? 139 ILE A CG2 1 
ATOM   856  C CD1 . ILE A 1 114 ? 1.102   -12.547 -9.199  1.00 10.09 ? 139 ILE A CD1 1 
ATOM   857  N N   . ALA A 1 115 ? 2.380   -14.435 -4.005  1.00 9.93  ? 140 ALA A N   1 
ATOM   858  C CA  . ALA A 1 115 ? 3.260   -15.188 -3.111  1.00 12.13 ? 140 ALA A CA  1 
ATOM   859  C C   . ALA A 1 115 ? 2.467   -15.929 -2.035  1.00 11.77 ? 140 ALA A C   1 
ATOM   860  O O   . ALA A 1 115 ? 2.745   -17.096 -1.741  1.00 12.04 ? 140 ALA A O   1 
ATOM   861  C CB  . ALA A 1 115 ? 4.329   -14.271 -2.508  1.00 12.94 ? 140 ALA A CB  1 
ATOM   862  N N   . GLN A 1 116 ? 1.460   -15.280 -1.454  1.00 10.24 ? 141 GLN A N   1 
ATOM   863  C CA  . GLN A 1 116 ? 0.615   -15.956 -0.471  1.00 9.61  ? 141 GLN A CA  1 
ATOM   864  C C   . GLN A 1 116 ? 0.011   -17.233 -1.041  1.00 11.00 ? 141 GLN A C   1 
ATOM   865  O O   . GLN A 1 116 ? -0.181  -18.215 -0.310  1.00 13.13 ? 141 GLN A O   1 
ATOM   866  C CB  . GLN A 1 116 ? -0.478  -14.996 -0.003  1.00 9.23  ? 141 GLN A CB  1 
ATOM   867  C CG  . GLN A 1 116 ? -1.611  -15.635 0.795   1.00 10.28 ? 141 GLN A CG  1 
ATOM   868  C CD  . GLN A 1 116 ? -1.169  -16.330 2.057   1.00 10.11 ? 141 GLN A CD  1 
ATOM   869  O OE1 . GLN A 1 116 ? -0.205  -15.934 2.692   1.00 13.11 ? 141 GLN A OE1 1 
ATOM   870  N NE2 . GLN A 1 116 ? -1.887  -17.379 2.431   1.00 12.47 ? 141 GLN A NE2 1 
ATOM   871  N N   . LEU A 1 117 ? -0.271  -17.247 -2.340  1.00 9.77  ? 142 LEU A N   1 
ATOM   872  C CA  . LEU A 1 117 ? -0.921  -18.377 -2.981  1.00 9.42  ? 142 LEU A CA  1 
ATOM   873  C C   . LEU A 1 117 ? 0.061   -19.430 -3.470  1.00 13.16 ? 142 LEU A C   1 
ATOM   874  O O   . LEU A 1 117 ? -0.371  -20.458 -4.010  1.00 13.99 ? 142 LEU A O   1 
ATOM   875  C CB  . LEU A 1 117 ? -1.788  -17.871 -4.124  1.00 10.29 ? 142 LEU A CB  1 
ATOM   876  C CG  . LEU A 1 117 ? -2.904  -16.950 -3.624  1.00 12.12 ? 142 LEU A CG  1 
ATOM   877  C CD1 . LEU A 1 117 ? -3.515  -16.186 -4.784  1.00 11.85 ? 142 LEU A CD1 1 
ATOM   878  C CD2 . LEU A 1 117 ? -3.959  -17.763 -2.898  1.00 12.70 ? 142 LEU A CD2 1 
ATOM   879  N N   . GLY A 1 118 ? 1.357   -19.210 -3.261  1.00 9.28  ? 143 GLY A N   1 
ATOM   880  C CA  . GLY A 1 118 ? 2.380   -20.143 -3.668  1.00 11.42 ? 143 GLY A CA  1 
ATOM   881  C C   . GLY A 1 118 ? 2.965   -19.892 -5.035  1.00 14.96 ? 143 GLY A C   1 
ATOM   882  O O   . GLY A 1 118 ? 3.688   -20.755 -5.551  1.00 18.31 ? 143 GLY A O   1 
ATOM   883  N N   . GLY A 1 119 ? 2.683   -18.741 -5.639  1.00 12.38 ? 144 GLY A N   1 
ATOM   884  C CA  . GLY A 1 119 ? 3.143   -18.453 -6.973  1.00 10.52 ? 144 GLY A CA  1 
ATOM   885  C C   . GLY A 1 119 ? 1.982   -18.391 -7.944  1.00 11.95 ? 144 GLY A C   1 
ATOM   886  O O   . GLY A 1 119 ? 0.831   -18.680 -7.597  1.00 10.85 ? 144 GLY A O   1 
ATOM   887  N N   . PRO A 1 120 ? 2.274   -17.998 -9.184  1.00 10.33 ? 145 PRO A N   1 
ATOM   888  C CA  . PRO A 1 120 ? 1.210   -17.887 -10.202 1.00 13.52 ? 145 PRO A CA  1 
ATOM   889  C C   . PRO A 1 120 ? 0.354   -19.142 -10.331 1.00 12.60 ? 145 PRO A C   1 
ATOM   890  O O   . PRO A 1 120 ? -0.873  -19.038 -10.494 1.00 12.95 ? 145 PRO A O   1 
ATOM   891  C CB  . PRO A 1 120 ? 1.991   -17.562 -11.485 1.00 12.48 ? 145 PRO A CB  1 
ATOM   892  C CG  . PRO A 1 120 ? 3.273   -16.883 -10.979 1.00 12.38 ? 145 PRO A CG  1 
ATOM   893  C CD  . PRO A 1 120 ? 3.597   -17.597 -9.690  1.00 11.20 ? 145 PRO A CD  1 
ATOM   894  N N   . GLY A 1 121 ? 0.965   -20.332 -10.229 1.00 11.45 ? 146 GLY A N   1 
ATOM   895  C CA  . GLY A 1 121 ? 0.199   -21.567 -10.295 1.00 11.51 ? 146 GLY A CA  1 
ATOM   896  C C   . GLY A 1 121 ? -0.887  -21.661 -9.239  1.00 11.77 ? 146 GLY A C   1 
ATOM   897  O O   . GLY A 1 121 ? -1.913  -22.317 -9.455  1.00 13.59 ? 146 GLY A O   1 
ATOM   898  N N   . GLY A 1 122 ? -0.676  -21.035 -8.079  1.00 12.07 ? 147 GLY A N   1 
ATOM   899  C CA  . GLY A 1 122 ? -1.701  -21.047 -7.048  1.00 10.60 ? 147 GLY A CA  1 
ATOM   900  C C   . GLY A 1 122 ? -2.928  -20.250 -7.430  1.00 11.91 ? 147 GLY A C   1 
ATOM   901  O O   . GLY A 1 122 ? -4.049  -20.599 -7.039  1.00 12.19 ? 147 GLY A O   1 
ATOM   902  N N   . VAL A 1 123 ? -2.740  -19.169 -8.190  1.00 12.19 ? 148 VAL A N   1 
ATOM   903  C CA  . VAL A 1 123 ? -3.876  -18.422 -8.718  1.00 11.88 ? 148 VAL A CA  1 
ATOM   904  C C   . VAL A 1 123 ? -4.639  -19.274 -9.732  1.00 13.31 ? 148 VAL A C   1 
ATOM   905  O O   . VAL A 1 123 ? -5.877  -19.348 -9.703  1.00 10.72 ? 148 VAL A O   1 
ATOM   906  C CB  . VAL A 1 123 ? -3.423  -17.072 -9.311  1.00 10.95 ? 148 VAL A CB  1 
ATOM   907  C CG1 . VAL A 1 123 ? -4.625  -16.202 -9.654  1.00 10.46 ? 148 VAL A CG1 1 
ATOM   908  C CG2 . VAL A 1 123 ? -2.503  -16.310 -8.364  1.00 12.86 ? 148 VAL A CG2 1 
ATOM   909  N N   . THR A 1 124 ? -3.908  -19.943 -10.629 1.00 11.98 ? 149 THR A N   1 
ATOM   910  C CA  . THR A 1 124 ? -4.545  -20.817 -11.609 1.00 10.93 ? 149 THR A CA  1 
ATOM   911  C C   . THR A 1 124 ? -5.298  -21.946 -10.930 1.00 9.46  ? 149 THR A C   1 
ATOM   912  O O   . THR A 1 124 ? -6.407  -22.296 -11.345 1.00 9.77  ? 149 THR A O   1 
ATOM   913  C CB  . THR A 1 124 ? -3.493  -21.382 -12.561 1.00 7.65  ? 149 THR A CB  1 
ATOM   914  O OG1 . THR A 1 124 ? -2.729  -20.301 -13.091 1.00 11.48 ? 149 THR A OG1 1 
ATOM   915  C CG2 . THR A 1 124 ? -4.167  -22.118 -13.712 1.00 12.39 ? 149 THR A CG2 1 
ATOM   916  N N   . ALA A 1 125 ? -4.726  -22.504 -9.856  1.00 10.55 ? 150 ALA A N   1 
ATOM   917  C CA  . ALA A 1 125 ? -5.391  -23.593 -9.149  1.00 12.04 ? 150 ALA A CA  1 
ATOM   918  C C   . ALA A 1 125 ? -6.723  -23.132 -8.570  1.00 12.68 ? 150 ALA A C   1 
ATOM   919  O O   . ALA A 1 125 ? -7.711  -23.875 -8.604  1.00 12.39 ? 150 ALA A O   1 
ATOM   920  C CB  . ALA A 1 125 ? -4.480  -24.160 -8.061  1.00 12.23 ? 150 ALA A CB  1 
ATOM   921  N N   . PHE A 1 126 ? -6.772  -21.913 -8.031  1.00 10.63 ? 151 PHE A N   1 
ATOM   922  C CA  . PHE A 1 126 ? -8.045  -21.385 -7.560  1.00 9.70  ? 151 PHE A CA  1 
ATOM   923  C C   . PHE A 1 126 ? -9.050  -21.261 -8.701  1.00 10.56 ? 151 PHE A C   1 
ATOM   924  O O   . PHE A 1 126 ? -10.215 -21.642 -8.551  1.00 11.11 ? 151 PHE A O   1 
ATOM   925  C CB  . PHE A 1 126 ? -7.858  -20.046 -6.853  1.00 8.28  ? 151 PHE A CB  1 
ATOM   926  C CG  . PHE A 1 126 ? -9.158  -19.367 -6.525  1.00 10.23 ? 151 PHE A CG  1 
ATOM   927  C CD1 . PHE A 1 126 ? -9.981  -19.882 -5.532  1.00 9.97  ? 151 PHE A CD1 1 
ATOM   928  C CD2 . PHE A 1 126 ? -9.591  -18.258 -7.233  1.00 10.03 ? 151 PHE A CD2 1 
ATOM   929  C CE1 . PHE A 1 126 ? -11.203 -19.285 -5.223  1.00 12.41 ? 151 PHE A CE1 1 
ATOM   930  C CE2 . PHE A 1 126 ? -10.813 -17.646 -6.921  1.00 13.57 ? 151 PHE A CE2 1 
ATOM   931  C CZ  . PHE A 1 126 ? -11.616 -18.165 -5.924  1.00 11.08 ? 151 PHE A CZ  1 
ATOM   932  N N   . ALA A 1 127 ? -8.622  -20.733 -9.854  1.00 10.17 ? 152 ALA A N   1 
ATOM   933  C CA  . ALA A 1 127 ? -9.515  -20.681 -11.013 1.00 9.46  ? 152 ALA A CA  1 
ATOM   934  C C   . ALA A 1 127 ? -10.093 -22.055 -11.331 1.00 10.40 ? 152 ALA A C   1 
ATOM   935  O O   . ALA A 1 127 ? -11.298 -22.195 -11.583 1.00 10.53 ? 152 ALA A O   1 
ATOM   936  C CB  . ALA A 1 127 ? -8.760  -20.143 -12.231 1.00 10.46 ? 152 ALA A CB  1 
ATOM   937  N N   . ARG A 1 128 ? -9.237  -23.083 -11.330 1.00 9.22  ? 153 ARG A N   1 
ATOM   938  C CA  . ARG A 1 128 ? -9.721  -24.429 -11.617 1.00 10.08 ? 153 ARG A CA  1 
ATOM   939  C C   . ARG A 1 128 ? -10.723 -24.893 -10.564 1.00 10.02 ? 153 ARG A C   1 
ATOM   940  O O   . ARG A 1 128 ? -11.714 -25.557 -10.897 1.00 12.45 ? 153 ARG A O   1 
ATOM   941  C CB  . ARG A 1 128 ? -8.554  -25.403 -11.712 1.00 11.33 ? 153 ARG A CB  1 
ATOM   942  C CG  . ARG A 1 128 ? -7.613  -25.115 -12.864 1.00 9.43  ? 153 ARG A CG  1 
ATOM   943  C CD  . ARG A 1 128 ? -8.254  -25.334 -14.263 1.00 10.13 ? 153 ARG A CD  1 
ATOM   944  N NE  . ARG A 1 128 ? -7.244  -25.043 -15.274 1.00 11.81 ? 153 ARG A NE  1 
ATOM   945  C CZ  . ARG A 1 128 ? -6.958  -23.830 -15.730 1.00 10.91 ? 153 ARG A CZ  1 
ATOM   946  N NH1 . ARG A 1 128 ? -7.710  -22.782 -15.434 1.00 10.53 ? 153 ARG A NH1 1 
ATOM   947  N NH2 . ARG A 1 128 ? -5.870  -23.656 -16.475 1.00 13.06 ? 153 ARG A NH2 1 
ATOM   948  N N   . ALA A 1 129 ? -10.487 -24.542 -9.292  1.00 10.07 ? 154 ALA A N   1 
ATOM   949  C CA  . ALA A 1 129 ? -11.379 -24.944 -8.206  1.00 10.61 ? 154 ALA A CA  1 
ATOM   950  C C   . ALA A 1 129 ? -12.758 -24.285 -8.254  1.00 15.15 ? 154 ALA A C   1 
ATOM   951  O O   . ALA A 1 129 ? -13.686 -24.797 -7.610  1.00 16.88 ? 154 ALA A O   1 
ATOM   952  C CB  . ALA A 1 129 ? -10.709 -24.669 -6.854  1.00 12.73 ? 154 ALA A CB  1 
ATOM   953  N N   . ILE A 1 130 ? -12.926 -23.167 -8.971  1.00 11.50 ? 155 ILE A N   1 
ATOM   954  C CA  . ILE A 1 130 ? -14.234 -22.542 -9.147  1.00 10.99 ? 155 ILE A CA  1 
ATOM   955  C C   . ILE A 1 130 ? -14.798 -22.769 -10.548 1.00 10.23 ? 155 ILE A C   1 
ATOM   956  O O   . ILE A 1 130 ? -15.755 -22.092 -10.945 1.00 16.13 ? 155 ILE A O   1 
ATOM   957  C CB  . ILE A 1 130 ? -14.256 -21.057 -8.739  1.00 11.88 ? 155 ILE A CB  1 
ATOM   958  C CG1 . ILE A 1 130 ? -13.368 -20.210 -9.660  1.00 11.49 ? 155 ILE A CG1 1 
ATOM   959  C CG2 . ILE A 1 130 ? -13.828 -20.922 -7.273  1.00 12.98 ? 155 ILE A CG2 1 
ATOM   960  C CD1 . ILE A 1 130 ? -13.602 -18.686 -9.528  1.00 14.00 ? 155 ILE A CD1 1 
ATOM   961  N N   . GLY A 1 131 ? -14.232 -23.711 -11.300 1.00 10.67 ? 156 GLY A N   1 
ATOM   962  C CA  . GLY A 1 131 ? -14.799 -24.107 -12.577 1.00 11.01 ? 156 GLY A CA  1 
ATOM   963  C C   . GLY A 1 131 ? -14.272 -23.392 -13.796 1.00 11.75 ? 156 GLY A C   1 
ATOM   964  O O   . GLY A 1 131 ? -14.812 -23.598 -14.890 1.00 13.75 ? 156 GLY A O   1 
ATOM   965  N N   . ASP A 1 132 ? -13.241 -22.566 -13.655 1.00 11.38 ? 157 ASP A N   1 
ATOM   966  C CA  . ASP A 1 132 ? -12.640 -21.859 -14.785 1.00 8.49  ? 157 ASP A CA  1 
ATOM   967  C C   . ASP A 1 132 ? -11.460 -22.682 -15.289 1.00 9.97  ? 157 ASP A C   1 
ATOM   968  O O   . ASP A 1 132 ? -10.413 -22.750 -14.635 1.00 12.19 ? 157 ASP A O   1 
ATOM   969  C CB  . ASP A 1 132 ? -12.206 -20.457 -14.361 1.00 7.98  ? 157 ASP A CB  1 
ATOM   970  C CG  . ASP A 1 132 ? -11.783 -19.589 -15.540 1.00 11.06 ? 157 ASP A CG  1 
ATOM   971  O OD1 . ASP A 1 132 ? -11.274 -20.126 -16.555 1.00 12.32 ? 157 ASP A OD1 1 
ATOM   972  O OD2 . ASP A 1 132 ? -11.933 -18.348 -15.446 1.00 11.69 ? 157 ASP A OD2 1 
ATOM   973  N N   . GLU A 1 133 ? -11.629 -23.294 -16.461 1.00 9.98  ? 158 GLU A N   1 
ATOM   974  C CA  . GLU A 1 133 ? -10.623 -24.151 -17.065 1.00 10.95 ? 158 GLU A CA  1 
ATOM   975  C C   . GLU A 1 133 ? -9.787  -23.418 -18.102 1.00 11.97 ? 158 GLU A C   1 
ATOM   976  O O   . GLU A 1 133 ? -8.932  -24.036 -18.746 1.00 14.52 ? 158 GLU A O   1 
ATOM   977  C CB  . GLU A 1 133 ? -11.284 -25.369 -17.714 1.00 11.28 ? 158 GLU A CB  1 
ATOM   978  C CG  . GLU A 1 133 ? -11.946 -26.334 -16.751 1.00 12.38 ? 158 GLU A CG  1 
ATOM   979  C CD  . GLU A 1 133 ? -12.616 -27.473 -17.504 1.00 34.04 ? 158 GLU A CD  1 
ATOM   980  O OE1 . GLU A 1 133 ? -11.890 -28.361 -18.008 1.00 31.15 ? 158 GLU A OE1 1 
ATOM   981  O OE2 . GLU A 1 133 ? -13.863 -27.466 -17.625 1.00 34.54 ? 158 GLU A OE2 1 
ATOM   982  N N   . THR A 1 134 ? -10.011 -22.122 -18.273 1.00 10.40 ? 159 THR A N   1 
ATOM   983  C CA  . THR A 1 134 ? -9.389  -21.328 -19.321 1.00 12.84 ? 159 THR A CA  1 
ATOM   984  C C   . THR A 1 134 ? -8.332  -20.364 -18.805 1.00 13.21 ? 159 THR A C   1 
ATOM   985  O O   . THR A 1 134 ? -7.245  -20.279 -19.387 1.00 11.73 ? 159 THR A O   1 
ATOM   986  C CB  . THR A 1 134 ? -10.485 -20.549 -20.059 1.00 11.73 ? 159 THR A CB  1 
ATOM   987  O OG1 . THR A 1 134 ? -11.359 -21.490 -20.699 1.00 12.15 ? 159 THR A OG1 1 
ATOM   988  C CG2 . THR A 1 134 ? -9.889  -19.598 -21.103 1.00 10.56 ? 159 THR A CG2 1 
ATOM   989  N N   . PHE A 1 135 ? -8.626  -19.646 -17.716 1.00 10.25 ? 160 PHE A N   1 
ATOM   990  C CA  . PHE A 1 135 ? -7.678  -18.729 -17.086 1.00 9.16  ? 160 PHE A CA  1 
ATOM   991  C C   . PHE A 1 135 ? -6.334  -19.405 -16.824 1.00 11.08 ? 160 PHE A C   1 
ATOM   992  O O   . PHE A 1 135 ? -6.270  -20.544 -16.349 1.00 10.63 ? 160 PHE A O   1 
ATOM   993  C CB  . PHE A 1 135 ? -8.297  -18.283 -15.748 1.00 11.20 ? 160 PHE A CB  1 
ATOM   994  C CG  . PHE A 1 135 ? -7.396  -17.417 -14.877 1.00 11.26 ? 160 PHE A CG  1 
ATOM   995  C CD1 . PHE A 1 135 ? -6.372  -17.969 -14.118 1.00 9.55  ? 160 PHE A CD1 1 
ATOM   996  C CD2 . PHE A 1 135 ? -7.632  -16.058 -14.779 1.00 11.62 ? 160 PHE A CD2 1 
ATOM   997  C CE1 . PHE A 1 135 ? -5.556  -17.173 -13.321 1.00 9.74  ? 160 PHE A CE1 1 
ATOM   998  C CE2 . PHE A 1 135 ? -6.830  -15.255 -13.974 1.00 10.51 ? 160 PHE A CE2 1 
ATOM   999  C CZ  . PHE A 1 135 ? -5.789  -15.820 -13.243 1.00 7.93  ? 160 PHE A CZ  1 
ATOM   1000 N N   . ARG A 1 136 ? -5.245  -18.674 -17.075 1.00 10.74 ? 161 ARG A N   1 
ATOM   1001 C CA  . ARG A 1 136 ? -3.932  -19.104 -16.593 1.00 9.24  ? 161 ARG A CA  1 
ATOM   1002 C C   . ARG A 1 136 ? -3.117  -17.895 -16.163 1.00 7.38  ? 161 ARG A C   1 
ATOM   1003 O O   . ARG A 1 136 ? -3.057  -16.895 -16.887 1.00 10.86 ? 161 ARG A O   1 
ATOM   1004 C CB  . ARG A 1 136 ? -3.144  -19.921 -17.644 1.00 10.59 ? 161 ARG A CB  1 
ATOM   1005 C CG  . ARG A 1 136 ? -3.053  -19.254 -19.023 1.00 10.62 ? 161 ARG A CG  1 
ATOM   1006 C CD  . ARG A 1 136 ? -2.404  -20.159 -20.063 1.00 11.85 ? 161 ARG A CD  1 
ATOM   1007 N NE  . ARG A 1 136 ? -0.986  -20.360 -19.790 1.00 11.22 ? 161 ARG A NE  1 
ATOM   1008 C CZ  . ARG A 1 136 ? -0.180  -21.116 -20.524 1.00 11.95 ? 161 ARG A CZ  1 
ATOM   1009 N NH1 . ARG A 1 136 ? -0.631  -21.818 -21.550 1.00 13.77 ? 161 ARG A NH1 1 
ATOM   1010 N NH2 . ARG A 1 136 ? 1.119   -21.145 -20.241 1.00 14.90 ? 161 ARG A NH2 1 
ATOM   1011 N N   . LEU A 1 137 ? -2.501  -17.983 -14.979 1.00 9.44  ? 162 LEU A N   1 
ATOM   1012 C CA  . LEU A 1 137 ? -1.469  -17.049 -14.548 1.00 9.19  ? 162 LEU A CA  1 
ATOM   1013 C C   . LEU A 1 137 ? -0.142  -17.788 -14.532 1.00 10.51 ? 162 LEU A C   1 
ATOM   1014 O O   . LEU A 1 137 ? -0.034  -18.874 -13.952 1.00 11.88 ? 162 LEU A O   1 
ATOM   1015 C CB  . LEU A 1 137 ? -1.771  -16.462 -13.167 1.00 11.10 ? 162 LEU A CB  1 
ATOM   1016 C CG  . LEU A 1 137 ? -1.036  -15.137 -12.942 1.00 11.95 ? 162 LEU A CG  1 
ATOM   1017 C CD1 . LEU A 1 137 ? -1.601  -14.081 -13.887 1.00 14.09 ? 162 LEU A CD1 1 
ATOM   1018 C CD2 . LEU A 1 137 ? -1.161  -14.676 -11.499 1.00 16.16 ? 162 LEU A CD2 1 
ATOM   1019 N N   . ASP A 1 138 ? 0.856   -17.188 -15.166 1.00 11.51 ? 163 ASP A N   1 
ATOM   1020 C CA  . ASP A 1 138 ? 2.153   -17.803 -15.382 1.00 8.85  ? 163 ASP A CA  1 
ATOM   1021 C C   . ASP A 1 138 ? 3.299   -17.022 -14.777 1.00 10.93 ? 163 ASP A C   1 
ATOM   1022 O O   . ASP A 1 138 ? 4.295   -17.629 -14.375 1.00 12.90 ? 163 ASP A O   1 
ATOM   1023 C CB  . ASP A 1 138 ? 2.405   -17.937 -16.884 1.00 9.86  ? 163 ASP A CB  1 
ATOM   1024 C CG  . ASP A 1 138 ? 1.426   -18.878 -17.541 1.00 10.88 ? 163 ASP A CG  1 
ATOM   1025 O OD1 . ASP A 1 138 ? 1.741   -20.084 -17.596 1.00 13.57 ? 163 ASP A OD1 1 
ATOM   1026 O OD2 . ASP A 1 138 ? 0.344   -18.437 -17.972 1.00 9.98  ? 163 ASP A OD2 1 
ATOM   1027 N N   . ARG A 1 139 ? 3.175   -15.700 -14.682 1.00 12.49 ? 164 ARG A N   1 
ATOM   1028 C CA  . ARG A 1 139 ? 4.260   -14.832 -14.251 1.00 11.17 ? 164 ARG A CA  1 
ATOM   1029 C C   . ARG A 1 139 ? 3.765   -13.859 -13.190 1.00 11.28 ? 164 ARG A C   1 
ATOM   1030 O O   . ARG A 1 139 ? 2.563   -13.657 -12.999 1.00 13.43 ? 164 ARG A O   1 
ATOM   1031 C CB  . ARG A 1 139 ? 4.858   -14.054 -15.438 1.00 9.92  ? 164 ARG A CB  1 
ATOM   1032 C CG  . ARG A 1 139 ? 5.605   -14.944 -16.428 1.00 10.16 ? 164 ARG A CG  1 
ATOM   1033 C CD  . ARG A 1 139 ? 5.925   -14.216 -17.734 1.00 9.77  ? 164 ARG A CD  1 
ATOM   1034 N NE  . ARG A 1 139 ? 4.709   -13.904 -18.481 1.00 12.07 ? 164 ARG A NE  1 
ATOM   1035 C CZ  . ARG A 1 139 ? 4.662   -13.193 -19.599 1.00 12.34 ? 164 ARG A CZ  1 
ATOM   1036 N NH1 . ARG A 1 139 ? 5.759   -12.737 -20.181 1.00 13.21 ? 164 ARG A NH1 1 
ATOM   1037 N NH2 . ARG A 1 139 ? 3.478   -12.912 -20.138 1.00 11.18 ? 164 ARG A NH2 1 
ATOM   1038 N N   . THR A 1 140 ? 4.728   -13.249 -12.503 1.00 10.07 ? 165 THR A N   1 
ATOM   1039 C CA  . THR A 1 140 ? 4.475   -12.195 -11.540 1.00 10.78 ? 165 THR A CA  1 
ATOM   1040 C C   . THR A 1 140 ? 4.464   -10.832 -12.232 1.00 10.57 ? 165 THR A C   1 
ATOM   1041 O O   . THR A 1 140 ? 4.653   -10.713 -13.445 1.00 10.73 ? 165 THR A O   1 
ATOM   1042 C CB  . THR A 1 140 ? 5.567   -12.212 -10.478 1.00 12.88 ? 165 THR A CB  1 
ATOM   1043 O OG1 . THR A 1 140 ? 6.845   -12.059 -11.114 1.00 12.75 ? 165 THR A OG1 1 
ATOM   1044 C CG2 . THR A 1 140 ? 5.528   -13.516 -9.715  1.00 13.30 ? 165 THR A CG2 1 
ATOM   1045 N N   . GLU A 1 141 ? 4.230   -9.776  -11.439 1.00 11.45 ? 166 GLU A N   1 
ATOM   1046 C CA  . GLU A 1 141 ? 4.395   -8.410  -11.928 1.00 11.16 ? 166 GLU A CA  1 
ATOM   1047 C C   . GLU A 1 141 ? 5.874   -8.044  -11.933 1.00 7.96  ? 166 GLU A C   1 
ATOM   1048 O O   . GLU A 1 141 ? 6.590   -8.379  -10.987 1.00 12.49 ? 166 GLU A O   1 
ATOM   1049 C CB  . GLU A 1 141 ? 3.685   -7.428  -11.002 1.00 13.71 ? 166 GLU A CB  1 
ATOM   1050 C CG  . GLU A 1 141 ? 2.202   -7.666  -10.888 1.00 9.67  ? 166 GLU A CG  1 
ATOM   1051 C CD  . GLU A 1 141 ? 1.461   -7.264  -12.131 1.00 12.13 ? 166 GLU A CD  1 
ATOM   1052 O OE1 . GLU A 1 141 ? 2.099   -6.720  -13.063 1.00 12.23 ? 166 GLU A OE1 1 
ATOM   1053 O OE2 . GLU A 1 141 ? 0.226   -7.499  -12.179 1.00 13.34 ? 166 GLU A OE2 1 
ATOM   1054 N N   . PRO A 1 142 ? 6.349   -7.333  -12.964 1.00 8.63  ? 167 PRO A N   1 
ATOM   1055 C CA  . PRO A 1 142 ? 5.591   -6.750  -14.085 1.00 11.08 ? 167 PRO A CA  1 
ATOM   1056 C C   . PRO A 1 142 ? 5.573   -7.577  -15.373 1.00 12.00 ? 167 PRO A C   1 
ATOM   1057 O O   . PRO A 1 142 ? 4.932   -7.170  -16.348 1.00 11.85 ? 167 PRO A O   1 
ATOM   1058 C CB  . PRO A 1 142 ? 6.333   -5.430  -14.318 1.00 10.68 ? 167 PRO A CB  1 
ATOM   1059 C CG  . PRO A 1 142 ? 7.785   -5.778  -14.006 1.00 13.92 ? 167 PRO A CG  1 
ATOM   1060 C CD  . PRO A 1 142 ? 7.752   -6.871  -12.954 1.00 11.18 ? 167 PRO A CD  1 
ATOM   1061 N N   . THR A 1 143 ? 6.227   -8.742  -15.428 1.00 10.97 ? 168 THR A N   1 
ATOM   1062 C CA  . THR A 1 143 ? 6.359   -9.430  -16.710 1.00 11.33 ? 168 THR A CA  1 
ATOM   1063 C C   . THR A 1 143 ? 5.050   -10.049 -17.189 1.00 10.64 ? 168 THR A C   1 
ATOM   1064 O O   . THR A 1 143 ? 4.924   -10.321 -18.388 1.00 11.86 ? 168 THR A O   1 
ATOM   1065 C CB  . THR A 1 143 ? 7.485   -10.473 -16.703 1.00 10.15 ? 168 THR A CB  1 
ATOM   1066 O OG1 . THR A 1 143 ? 7.205   -11.503 -15.755 1.00 13.80 ? 168 THR A OG1 1 
ATOM   1067 C CG2 . THR A 1 143 ? 8.848   -9.826  -16.394 1.00 13.89 ? 168 THR A CG2 1 
ATOM   1068 N N   . LEU A 1 144 ? 4.050   -10.226 -16.314 1.00 10.89 ? 169 LEU A N   1 
ATOM   1069 C CA  . LEU A 1 144 ? 2.762   -10.725 -16.809 1.00 12.12 ? 169 LEU A CA  1 
ATOM   1070 C C   . LEU A 1 144 ? 2.071   -9.785  -17.799 1.00 13.80 ? 169 LEU A C   1 
ATOM   1071 O O   . LEU A 1 144 ? 1.087   -10.202 -18.429 1.00 12.41 ? 169 LEU A O   1 
ATOM   1072 C CB  . LEU A 1 144 ? 1.811   -11.138 -15.668 1.00 12.16 ? 169 LEU A CB  1 
ATOM   1073 C CG  . LEU A 1 144 ? 1.287   -10.049 -14.733 1.00 10.64 ? 169 LEU A CG  1 
ATOM   1074 C CD1 . LEU A 1 144 ? 0.057   -9.322  -15.282 1.00 12.09 ? 169 LEU A CD1 1 
ATOM   1075 C CD2 . LEU A 1 144 ? 0.942   -10.645 -13.389 1.00 11.00 ? 169 LEU A CD2 1 
ATOM   1076 N N   . ASN A 1 145 ? 2.576   -8.566  -17.992 1.00 11.75 ? 170 ASN A N   1 
ATOM   1077 C CA  . ASN A 1 145 ? 1.940   -7.574  -18.856 1.00 11.89 ? 170 ASN A CA  1 
ATOM   1078 C C   . ASN A 1 145 ? 2.571   -7.463  -20.242 1.00 11.35 ? 170 ASN A C   1 
ATOM   1079 O O   . ASN A 1 145 ? 2.244   -6.522  -20.978 1.00 12.18 ? 170 ASN A O   1 
ATOM   1080 C CB  . ASN A 1 145 ? 1.969   -6.197  -18.189 1.00 13.27 ? 170 ASN A CB  1 
ATOM   1081 C CG  . ASN A 1 145 ? 1.317   -6.208  -16.840 1.00 11.57 ? 170 ASN A CG  1 
ATOM   1082 O OD1 . ASN A 1 145 ? 0.102   -6.329  -16.732 1.00 14.74 ? 170 ASN A OD1 1 
ATOM   1083 N ND2 . ASN A 1 145 ? 2.127   -6.123  -15.790 1.00 13.09 ? 170 ASN A ND2 1 
ATOM   1084 N N   . THR A 1 146 ? 3.450   -8.398  -20.626 1.00 10.24 ? 171 THR A N   1 
ATOM   1085 C CA  . THR A 1 146 ? 4.154   -8.259  -21.906 1.00 14.11 ? 171 THR A CA  1 
ATOM   1086 C C   . THR A 1 146 ? 3.214   -8.299  -23.111 1.00 12.49 ? 171 THR A C   1 
ATOM   1087 O O   . THR A 1 146 ? 3.505   -7.671  -24.138 1.00 12.66 ? 171 THR A O   1 
ATOM   1088 C CB  . THR A 1 146 ? 5.269   -9.300  -22.053 1.00 12.76 ? 171 THR A CB  1 
ATOM   1089 O OG1 . THR A 1 146 ? 4.763   -10.611 -21.790 1.00 14.14 ? 171 THR A OG1 1 
ATOM   1090 C CG2 . THR A 1 146 ? 6.399   -8.996  -21.085 1.00 15.37 ? 171 THR A CG2 1 
ATOM   1091 N N   . ALA A 1 147 ? 2.107   -9.044  -23.023 1.00 9.84  ? 172 ALA A N   1 
ATOM   1092 C CA  . ALA A 1 147 ? 1.025   -8.971  -24.009 1.00 10.27 ? 172 ALA A CA  1 
ATOM   1093 C C   . ALA A 1 147 ? 1.488   -9.306  -25.432 1.00 13.71 ? 172 ALA A C   1 
ATOM   1094 O O   . ALA A 1 147 ? 0.994   -8.745  -26.413 1.00 14.59 ? 172 ALA A O   1 
ATOM   1095 C CB  . ALA A 1 147 ? 0.320   -7.614  -23.947 1.00 12.48 ? 172 ALA A CB  1 
ATOM   1096 N N   . ILE A 1 148 ? 2.420   -10.241 -25.555 1.00 13.49 ? 173 ILE A N   1 
ATOM   1097 C CA  . ILE A 1 148 ? 2.971   -10.578 -26.877 1.00 16.83 ? 173 ILE A CA  1 
ATOM   1098 C C   . ILE A 1 148 ? 1.936   -11.356 -27.683 1.00 17.01 ? 173 ILE A C   1 
ATOM   1099 O O   . ILE A 1 148 ? 1.349   -12.322 -27.165 1.00 14.82 ? 173 ILE A O   1 
ATOM   1100 C CB  . ILE A 1 148 ? 4.261   -11.384 -26.721 1.00 16.92 ? 173 ILE A CB  1 
ATOM   1101 C CG1 . ILE A 1 148 ? 5.339   -10.546 -26.036 1.00 16.84 ? 173 ILE A CG1 1 
ATOM   1102 C CG2 . ILE A 1 148 ? 4.743   -11.892 -28.082 1.00 17.97 ? 173 ILE A CG2 1 
ATOM   1103 C CD1 . ILE A 1 148 ? 6.454   -11.369 -25.428 1.00 18.11 ? 173 ILE A CD1 1 
ATOM   1104 N N   . PRO A 1 149 ? 1.706   -11.006 -28.950 1.00 17.76 ? 174 PRO A N   1 
ATOM   1105 C CA  . PRO A 1 149 ? 0.695   -11.709 -29.750 1.00 16.12 ? 174 PRO A CA  1 
ATOM   1106 C C   . PRO A 1 149 ? 1.014   -13.192 -29.877 1.00 16.47 ? 174 PRO A C   1 
ATOM   1107 O O   . PRO A 1 149 ? 2.148   -13.577 -30.170 1.00 20.06 ? 174 PRO A O   1 
ATOM   1108 C CB  . PRO A 1 149 ? 0.788   -11.007 -31.113 1.00 22.80 ? 174 PRO A CB  1 
ATOM   1109 C CG  . PRO A 1 149 ? 1.330   -9.649  -30.807 1.00 23.56 ? 174 PRO A CG  1 
ATOM   1110 C CD  . PRO A 1 149 ? 2.307   -9.875  -29.686 1.00 19.48 ? 174 PRO A CD  1 
ATOM   1111 N N   . GLY A 1 150 ? -0.008  -14.025 -29.665 1.00 15.34 ? 175 GLY A N   1 
ATOM   1112 C CA  . GLY A 1 150 ? 0.137   -15.468 -29.738 1.00 17.81 ? 175 GLY A CA  1 
ATOM   1113 C C   . GLY A 1 150 ? 0.638   -16.130 -28.473 1.00 16.82 ? 175 GLY A C   1 
ATOM   1114 O O   . GLY A 1 150 ? 0.563   -17.362 -28.361 1.00 19.73 ? 175 GLY A O   1 
ATOM   1115 N N   . ASP A 1 151 ? 1.141   -15.366 -27.521 1.00 16.81 ? 176 ASP A N   1 
ATOM   1116 C CA  . ASP A 1 151 ? 1.659   -15.926 -26.285 1.00 14.35 ? 176 ASP A CA  1 
ATOM   1117 C C   . ASP A 1 151 ? 0.499   -16.269 -25.354 1.00 12.66 ? 176 ASP A C   1 
ATOM   1118 O O   . ASP A 1 151 ? -0.273  -15.377 -24.988 1.00 12.37 ? 176 ASP A O   1 
ATOM   1119 C CB  . ASP A 1 151 ? 2.584   -14.895 -25.654 1.00 11.69 ? 176 ASP A CB  1 
ATOM   1120 C CG  . ASP A 1 151 ? 3.305   -15.399 -24.435 1.00 14.22 ? 176 ASP A CG  1 
ATOM   1121 O OD1 . ASP A 1 151 ? 3.016   -16.508 -23.936 1.00 14.29 ? 176 ASP A OD1 1 
ATOM   1122 O OD2 . ASP A 1 151 ? 4.188   -14.654 -23.973 1.00 17.72 ? 176 ASP A OD2 1 
ATOM   1123 N N   . PRO A 1 152 ? 0.321   -17.536 -24.968 1.00 13.09 ? 177 PRO A N   1 
ATOM   1124 C CA  . PRO A 1 152 ? -0.814  -17.884 -24.098 1.00 11.59 ? 177 PRO A CA  1 
ATOM   1125 C C   . PRO A 1 152 ? -0.594  -17.551 -22.630 1.00 12.93 ? 177 PRO A C   1 
ATOM   1126 O O   . PRO A 1 152 ? -1.540  -17.662 -21.837 1.00 10.85 ? 177 PRO A O   1 
ATOM   1127 C CB  . PRO A 1 152 ? -0.959  -19.397 -24.290 1.00 13.55 ? 177 PRO A CB  1 
ATOM   1128 C CG  . PRO A 1 152 ? 0.396   -19.859 -24.677 1.00 16.80 ? 177 PRO A CG  1 
ATOM   1129 C CD  . PRO A 1 152 ? 1.107   -18.721 -25.359 1.00 12.22 ? 177 PRO A CD  1 
ATOM   1130 N N   . ARG A 1 153 ? 0.614   -17.167 -22.245 1.00 12.40 ? 178 ARG A N   1 
ATOM   1131 C CA  . ARG A 1 153 ? 0.885   -16.883 -20.843 1.00 9.69  ? 178 ARG A CA  1 
ATOM   1132 C C   . ARG A 1 153 ? 0.023   -15.723 -20.360 1.00 9.76  ? 178 ARG A C   1 
ATOM   1133 O O   . ARG A 1 153 ? -0.162  -14.721 -21.061 1.00 11.76 ? 178 ARG A O   1 
ATOM   1134 C CB  . ARG A 1 153 ? 2.361   -16.560 -20.654 1.00 10.69 ? 178 ARG A CB  1 
ATOM   1135 C CG  . ARG A 1 153 ? 3.224   -17.796 -20.817 1.00 12.67 ? 178 ARG A CG  1 
ATOM   1136 C CD  . ARG A 1 153 ? 4.660   -17.471 -20.538 1.00 12.17 ? 178 ARG A CD  1 
ATOM   1137 N NE  . ARG A 1 153 ? 5.190   -16.581 -21.559 1.00 14.68 ? 178 ARG A NE  1 
ATOM   1138 C CZ  . ARG A 1 153 ? 6.400   -16.044 -21.536 1.00 11.92 ? 178 ARG A CZ  1 
ATOM   1139 N NH1 . ARG A 1 153 ? 7.261   -16.314 -20.568 1.00 14.22 ? 178 ARG A NH1 1 
ATOM   1140 N NH2 . ARG A 1 153 ? 6.764   -15.228 -22.521 1.00 16.50 ? 178 ARG A NH2 1 
ATOM   1141 N N   . ASP A 1 154 ? -0.535  -15.876 -19.162 1.00 11.39 ? 179 ASP A N   1 
ATOM   1142 C CA  . ASP A 1 154 ? -1.245  -14.779 -18.504 1.00 9.26  ? 179 ASP A CA  1 
ATOM   1143 C C   . ASP A 1 154 ? -2.434  -14.290 -19.330 1.00 10.26 ? 179 ASP A C   1 
ATOM   1144 O O   . ASP A 1 154 ? -2.709  -13.093 -19.416 1.00 10.70 ? 179 ASP A O   1 
ATOM   1145 C CB  . ASP A 1 154 ? -0.280  -13.651 -18.148 1.00 11.56 ? 179 ASP A CB  1 
ATOM   1146 C CG  . ASP A 1 154 ? 0.949   -14.172 -17.420 1.00 12.69 ? 179 ASP A CG  1 
ATOM   1147 O OD1 . ASP A 1 154 ? 0.802   -14.670 -16.266 1.00 11.56 ? 179 ASP A OD1 1 
ATOM   1148 O OD2 . ASP A 1 154 ? 2.059   -14.113 -18.021 1.00 12.43 ? 179 ASP A OD2 1 
ATOM   1149 N N   . THR A 1 155 ? -3.166  -15.232 -19.921 1.00 10.74 ? 180 THR A N   1 
ATOM   1150 C CA  . THR A 1 155 ? -4.310  -14.916 -20.758 1.00 9.55  ? 180 THR A CA  1 
ATOM   1151 C C   . THR A 1 155 ? -5.553  -15.635 -20.255 1.00 9.30  ? 180 THR A C   1 
ATOM   1152 O O   . THR A 1 155 ? -5.483  -16.597 -19.477 1.00 10.11 ? 180 THR A O   1 
ATOM   1153 C CB  . THR A 1 155 ? -4.082  -15.314 -22.226 1.00 8.89  ? 180 THR A CB  1 
ATOM   1154 O OG1 . THR A 1 155 ? -3.958  -16.739 -22.333 1.00 10.93 ? 180 THR A OG1 1 
ATOM   1155 C CG2 . THR A 1 155 ? -2.866  -14.640 -22.826 1.00 9.87  ? 180 THR A CG2 1 
ATOM   1156 N N   . THR A 1 156 ? -6.695  -15.140 -20.728 1.00 9.26  ? 181 THR A N   1 
ATOM   1157 C CA  . THR A 1 156 ? -7.963  -15.852 -20.657 1.00 8.52  ? 181 THR A CA  1 
ATOM   1158 C C   . THR A 1 156 ? -8.823  -15.407 -21.833 1.00 9.24  ? 181 THR A C   1 
ATOM   1159 O O   . THR A 1 156 ? -8.426  -14.552 -22.629 1.00 10.11 ? 181 THR A O   1 
ATOM   1160 C CB  . THR A 1 156 ? -8.649  -15.612 -19.308 1.00 9.30  ? 181 THR A CB  1 
ATOM   1161 O OG1 . THR A 1 156 ? -9.674  -16.601 -19.114 1.00 10.93 ? 181 THR A OG1 1 
ATOM   1162 C CG2 . THR A 1 156 ? -9.261  -14.223 -19.239 1.00 10.16 ? 181 THR A CG2 1 
ATOM   1163 N N   . THR A 1 157 ? -10.002 -15.990 -21.930 1.00 9.87  ? 182 THR A N   1 
ATOM   1164 C CA  . THR A 1 157 ? -10.951 -15.544 -22.941 1.00 10.12 ? 182 THR A CA  1 
ATOM   1165 C C   . THR A 1 157 ? -12.034 -14.673 -22.304 1.00 9.18  ? 182 THR A C   1 
ATOM   1166 O O   . THR A 1 157 ? -12.323 -14.802 -21.102 1.00 9.66  ? 182 THR A O   1 
ATOM   1167 C CB  . THR A 1 157 ? -11.646 -16.729 -23.632 1.00 8.39  ? 182 THR A CB  1 
ATOM   1168 O OG1 . THR A 1 157 ? -12.494 -17.402 -22.689 1.00 10.06 ? 182 THR A OG1 1 
ATOM   1169 C CG2 . THR A 1 157 ? -10.631 -17.713 -24.218 1.00 10.22 ? 182 THR A CG2 1 
ATOM   1170 N N   . PRO A 1 158 ? -12.657 -13.777 -23.086 1.00 8.60  ? 183 PRO A N   1 
ATOM   1171 C CA  . PRO A 1 158 ? -13.758 -12.970 -22.525 1.00 8.42  ? 183 PRO A CA  1 
ATOM   1172 C C   . PRO A 1 158 ? -14.891 -13.814 -21.968 1.00 10.59 ? 183 PRO A C   1 
ATOM   1173 O O   . PRO A 1 158 ? -15.455 -13.482 -20.915 1.00 10.71 ? 183 PRO A O   1 
ATOM   1174 C CB  . PRO A 1 158 ? -14.198 -12.110 -23.717 1.00 11.66 ? 183 PRO A CB  1 
ATOM   1175 C CG  . PRO A 1 158 ? -12.928 -11.983 -24.566 1.00 10.56 ? 183 PRO A CG  1 
ATOM   1176 C CD  . PRO A 1 158 ? -12.271 -13.323 -24.438 1.00 8.57  ? 183 PRO A CD  1 
ATOM   1177 N N   . ARG A 1 159 ? -15.267 -14.884 -22.672 1.00 8.74  ? 184 ARG A N   1 
ATOM   1178 C CA  . ARG A 1 159 ? -16.363 -15.738 -22.206 1.00 10.19 ? 184 ARG A CA  1 
ATOM   1179 C C   . ARG A 1 159 ? -16.049 -16.329 -20.842 1.00 10.60 ? 184 ARG A C   1 
ATOM   1180 O O   . ARG A 1 159 ? -16.882 -16.301 -19.927 1.00 9.96  ? 184 ARG A O   1 
ATOM   1181 C CB  . ARG A 1 159 ? -16.635 -16.856 -23.216 1.00 9.38  ? 184 ARG A CB  1 
ATOM   1182 C CG  . ARG A 1 159 ? -17.893 -17.675 -22.942 1.00 9.05  ? 184 ARG A CG  1 
ATOM   1183 C CD  . ARG A 1 159 ? -17.890 -19.013 -23.697 1.00 10.12 ? 184 ARG A CD  1 
ATOM   1184 N NE  . ARG A 1 159 ? -17.918 -18.822 -25.140 1.00 11.45 ? 184 ARG A NE  1 
ATOM   1185 C CZ  . ARG A 1 159 ? -19.011 -18.691 -25.875 1.00 11.71 ? 184 ARG A CZ  1 
ATOM   1186 N NH1 . ARG A 1 159 ? -20.222 -18.718 -25.335 1.00 13.30 ? 184 ARG A NH1 1 
ATOM   1187 N NH2 . ARG A 1 159 ? -18.886 -18.540 -27.190 1.00 12.52 ? 184 ARG A NH2 1 
ATOM   1188 N N   . ALA A 1 160 ? -14.846 -16.883 -20.692 1.00 10.42 ? 185 ALA A N   1 
ATOM   1189 C CA  . ALA A 1 160 ? -14.469 -17.467 -19.413 1.00 10.92 ? 185 ALA A CA  1 
ATOM   1190 C C   . ALA A 1 160 ? -14.435 -16.419 -18.319 1.00 10.01 ? 185 ALA A C   1 
ATOM   1191 O O   . ALA A 1 160 ? -14.859 -16.680 -17.180 1.00 10.68 ? 185 ALA A O   1 
ATOM   1192 C CB  . ALA A 1 160 ? -13.107 -18.141 -19.536 1.00 11.82 ? 185 ALA A CB  1 
ATOM   1193 N N   . MET A 1 161 ? -13.938 -15.219 -18.625 1.00 8.83  ? 186 MET A N   1 
ATOM   1194 C CA  . MET A 1 161 ? -13.652 -14.377 -17.483 1.00 10.45 ? 186 MET A CA  1 
ATOM   1195 C C   . MET A 1 161 ? -14.967 -13.699 -17.067 1.00 10.37 ? 186 MET A C   1 
ATOM   1196 O O   . MET A 1 161 ? -15.174 -13.387 -15.889 1.00 10.26 ? 186 MET A O   1 
ATOM   1197 C CB  . MET A 1 161 ? -12.613 -13.325 -17.886 1.00 11.31 ? 186 MET A CB  1 
ATOM   1198 C CG  . MET A 1 161 ? -12.306 -12.237 -16.867 1.00 10.79 ? 186 MET A CG  1 
ATOM   1199 S SD  . MET A 1 161 ? -11.460 -13.126 -15.484 1.00 12.77 ? 186 MET A SD  1 
ATOM   1200 C CE  . MET A 1 161 ? -9.875  -12.301 -15.599 1.00 24.61 ? 186 MET A CE  1 
ATOM   1201 N N   . ALA A 1 162 ? -15.913 -13.537 -18.006 1.00 7.89  ? 187 ALA A N   1 
ATOM   1202 C CA  . ALA A 1 162 ? -17.240 -13.048 -17.624 1.00 10.48 ? 187 ALA A CA  1 
ATOM   1203 C C   . ALA A 1 162 ? -17.986 -14.076 -16.779 1.00 9.67  ? 187 ALA A C   1 
ATOM   1204 O O   . ALA A 1 162 ? -18.648 -13.719 -15.796 1.00 10.08 ? 187 ALA A O   1 
ATOM   1205 C CB  . ALA A 1 162 ? -18.061 -12.678 -18.860 1.00 10.00 ? 187 ALA A CB  1 
ATOM   1206 N N   . GLN A 1 163 ? -17.905 -15.358 -17.161 1.00 10.42 ? 188 GLN A N   1 
ATOM   1207 C CA  . GLN A 1 163 ? -18.526 -16.399 -16.350 1.00 9.65  ? 188 GLN A CA  1 
ATOM   1208 C C   . GLN A 1 163 ? -17.909 -16.459 -14.953 1.00 11.56 ? 188 GLN A C   1 
ATOM   1209 O O   . GLN A 1 163 ? -18.630 -16.591 -13.959 1.00 10.38 ? 188 GLN A O   1 
ATOM   1210 C CB  . GLN A 1 163 ? -18.415 -17.746 -17.064 1.00 11.18 ? 188 GLN A CB  1 
ATOM   1211 C CG  . GLN A 1 163 ? -18.986 -18.933 -16.281 1.00 11.83 ? 188 GLN A CG  1 
ATOM   1212 C CD  . GLN A 1 163 ? -20.449 -18.754 -15.897 1.00 12.41 ? 188 GLN A CD  1 
ATOM   1213 O OE1 . GLN A 1 163 ? -20.883 -19.225 -14.841 1.00 19.69 ? 188 GLN A OE1 1 
ATOM   1214 N NE2 . GLN A 1 163 ? -21.215 -18.072 -16.746 1.00 13.97 ? 188 GLN A NE2 1 
ATOM   1215 N N   . THR A 1 164 ? -16.576 -16.345 -14.857 1.00 9.76  ? 189 THR A N   1 
ATOM   1216 C CA  . THR A 1 164 ? -15.933 -16.376 -13.543 1.00 10.81 ? 189 THR A CA  1 
ATOM   1217 C C   . THR A 1 164 ? -16.290 -15.151 -12.704 1.00 11.31 ? 189 THR A C   1 
ATOM   1218 O O   . THR A 1 164 ? -16.589 -15.277 -11.506 1.00 11.14 ? 189 THR A O   1 
ATOM   1219 C CB  . THR A 1 164 ? -14.421 -16.536 -13.703 1.00 14.37 ? 189 THR A CB  1 
ATOM   1220 O OG1 . THR A 1 164 ? -14.150 -17.852 -14.184 1.00 14.51 ? 189 THR A OG1 1 
ATOM   1221 C CG2 . THR A 1 164 ? -13.731 -16.349 -12.369 1.00 18.72 ? 189 THR A CG2 1 
ATOM   1222 N N   . LEU A 1 165 ? -16.288 -13.962 -13.310 1.00 9.15  ? 190 LEU A N   1 
ATOM   1223 C CA  . LEU A 1 165 ? -16.661 -12.768 -12.560 1.00 9.39  ? 190 LEU A CA  1 
ATOM   1224 C C   . LEU A 1 165 ? -18.099 -12.864 -12.069 1.00 8.76  ? 190 LEU A C   1 
ATOM   1225 O O   . LEU A 1 165 ? -18.407 -12.438 -10.943 1.00 9.42  ? 190 LEU A O   1 
ATOM   1226 C CB  . LEU A 1 165 ? -16.443 -11.515 -13.412 1.00 10.18 ? 190 LEU A CB  1 
ATOM   1227 C CG  . LEU A 1 165 ? -16.583 -10.172 -12.682 1.00 9.81  ? 190 LEU A CG  1 
ATOM   1228 C CD1 . LEU A 1 165 ? -15.549 -10.038 -11.561 1.00 12.50 ? 190 LEU A CD1 1 
ATOM   1229 C CD2 . LEU A 1 165 ? -16.455 -9.014  -13.666 1.00 12.65 ? 190 LEU A CD2 1 
ATOM   1230 N N   . ARG A 1 166 ? -18.995 -13.439 -12.883 1.00 8.61  ? 191 ARG A N   1 
ATOM   1231 C CA  . ARG A 1 166 ? -20.359 -13.664 -12.402 1.00 10.73 ? 191 ARG A CA  1 
ATOM   1232 C C   . ARG A 1 166 ? -20.371 -14.602 -11.193 1.00 12.60 ? 191 ARG A C   1 
ATOM   1233 O O   . ARG A 1 166 ? -21.000 -14.307 -10.170 1.00 10.68 ? 191 ARG A O   1 
ATOM   1234 C CB  . ARG A 1 166 ? -21.285 -14.165 -13.517 1.00 13.53 ? 191 ARG A CB  1 
ATOM   1235 C CG  . ARG A 1 166 ? -22.651 -14.577 -12.964 1.00 12.30 ? 191 ARG A CG  1 
ATOM   1236 C CD  . ARG A 1 166 ? -23.555 -15.263 -13.955 1.00 16.58 ? 191 ARG A CD  1 
ATOM   1237 N NE  . ARG A 1 166 ? -24.926 -15.240 -13.450 1.00 15.11 ? 191 ARG A NE  1 
ATOM   1238 C CZ  . ARG A 1 166 ? -25.994 -15.538 -14.173 1.00 12.61 ? 191 ARG A CZ  1 
ATOM   1239 N NH1 . ARG A 1 166 ? -25.886 -15.911 -15.437 1.00 16.53 ? 191 ARG A NH1 1 
ATOM   1240 N NH2 . ARG A 1 166 ? -27.196 -15.471 -13.609 1.00 16.87 ? 191 ARG A NH2 1 
ATOM   1241 N N   . GLN A 1 167 ? -19.662 -15.729 -11.285 1.00 10.45 ? 192 GLN A N   1 
ATOM   1242 C CA  . GLN A 1 167 ? -19.626 -16.668 -10.161 1.00 10.12 ? 192 GLN A CA  1 
ATOM   1243 C C   . GLN A 1 167 ? -19.053 -16.026 -8.901  1.00 10.50 ? 192 GLN A C   1 
ATOM   1244 O O   . GLN A 1 167 ? -19.550 -16.275 -7.797  1.00 11.46 ? 192 GLN A O   1 
ATOM   1245 C CB  . GLN A 1 167 ? -18.832 -17.919 -10.532 1.00 12.52 ? 192 GLN A CB  1 
ATOM   1246 C CG  . GLN A 1 167 ? -19.435 -18.720 -11.658 1.00 13.11 ? 192 GLN A CG  1 
ATOM   1247 C CD  . GLN A 1 167 ? -20.680 -19.439 -11.217 1.00 28.88 ? 192 GLN A CD  1 
ATOM   1248 O OE1 . GLN A 1 167 ? -20.674 -20.138 -10.204 1.00 32.41 ? 192 GLN A OE1 1 
ATOM   1249 N NE2 . GLN A 1 167 ? -21.766 -19.257 -11.956 1.00 29.54 ? 192 GLN A NE2 1 
ATOM   1250 N N   . LEU A 1 168 ? -18.027 -15.177 -9.053  1.00 9.20  ? 193 LEU A N   1 
ATOM   1251 C CA  . LEU A 1 168 ? -17.351 -14.582 -7.905  1.00 10.55 ? 193 LEU A CA  1 
ATOM   1252 C C   . LEU A 1 168 ? -18.189 -13.498 -7.248  1.00 11.10 ? 193 LEU A C   1 
ATOM   1253 O O   . LEU A 1 168 ? -18.162 -13.357 -6.020  1.00 13.11 ? 193 LEU A O   1 
ATOM   1254 C CB  . LEU A 1 168 ? -16.007 -13.987 -8.317  1.00 9.13  ? 193 LEU A CB  1 
ATOM   1255 C CG  . LEU A 1 168 ? -14.871 -14.933 -8.683  1.00 11.01 ? 193 LEU A CG  1 
ATOM   1256 C CD1 . LEU A 1 168 ? -13.686 -14.094 -9.121  1.00 11.65 ? 193 LEU A CD1 1 
ATOM   1257 C CD2 . LEU A 1 168 ? -14.522 -15.834 -7.482  1.00 11.68 ? 193 LEU A CD2 1 
ATOM   1258 N N   . THR A 1 169 ? -18.919 -12.707 -8.036  1.00 10.53 ? 194 THR A N   1 
ATOM   1259 C CA  . THR A 1 169 ? -19.588 -11.517 -7.500  1.00 10.96 ? 194 THR A CA  1 
ATOM   1260 C C   . THR A 1 169 ? -21.088 -11.685 -7.316  1.00 10.32 ? 194 THR A C   1 
ATOM   1261 O O   . THR A 1 169 ? -21.672 -10.981 -6.487  1.00 12.45 ? 194 THR A O   1 
ATOM   1262 C CB  . THR A 1 169 ? -19.363 -10.294 -8.401  1.00 9.85  ? 194 THR A CB  1 
ATOM   1263 O OG1 . THR A 1 169 ? -19.914 -10.547 -9.705  1.00 10.94 ? 194 THR A OG1 1 
ATOM   1264 C CG2 . THR A 1 169 ? -17.871 -9.946  -8.508  1.00 13.81 ? 194 THR A CG2 1 
ATOM   1265 N N   . LEU A 1 170 ? -21.737 -12.564 -8.092  1.00 9.20  ? 195 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 170 ? -23.177 -12.768 -7.987  1.00 11.93 ? 195 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 170 ? -23.572 -14.203 -7.671  1.00 11.99 ? 195 LEU A C   1 
ATOM   1268 O O   . LEU A 1 170 ? -24.723 -14.440 -7.284  1.00 15.56 ? 195 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 170 ? -23.869 -12.341 -9.293  1.00 10.95 ? 195 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 170 ? -23.603 -10.908 -9.760  1.00 13.16 ? 195 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 170 ? -24.113 -10.714 -11.174 1.00 13.98 ? 195 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 170 ? -24.255 -9.895  -8.831  1.00 12.87 ? 195 LEU A CD2 1 
ATOM   1273 N N   . GLY A 1 171 ? -22.669 -15.157 -7.840  1.00 10.48 ? 196 GLY A N   1 
ATOM   1274 C CA  . GLY A 1 171 ? -22.920 -16.541 -7.515  1.00 11.56 ? 196 GLY A CA  1 
ATOM   1275 C C   . GLY A 1 171 ? -22.288 -16.946 -6.198  1.00 9.71  ? 196 GLY A C   1 
ATOM   1276 O O   . GLY A 1 171 ? -22.182 -16.153 -5.256  1.00 11.32 ? 196 GLY A O   1 
ATOM   1277 N N   . HIS A 1 172 ? -21.862 -18.200 -6.127  1.00 11.56 ? 197 HIS A N   1 
ATOM   1278 C CA  . HIS A 1 172 ? -21.455 -18.790 -4.860  1.00 6.74  ? 197 HIS A CA  1 
ATOM   1279 C C   . HIS A 1 172 ? -20.078 -19.434 -4.936  1.00 9.47  ? 197 HIS A C   1 
ATOM   1280 O O   . HIS A 1 172 ? -19.783 -20.386 -4.207  1.00 13.01 ? 197 HIS A O   1 
ATOM   1281 C CB  . HIS A 1 172 ? -22.545 -19.718 -4.310  1.00 10.71 ? 197 HIS A CB  1 
ATOM   1282 C CG  . HIS A 1 172 ? -23.744 -18.951 -3.875  1.00 11.20 ? 197 HIS A CG  1 
ATOM   1283 N ND1 . HIS A 1 172 ? -23.804 -18.324 -2.652  1.00 14.26 ? 197 HIS A ND1 1 
ATOM   1284 C CD2 . HIS A 1 172 ? -24.880 -18.618 -4.530  1.00 17.16 ? 197 HIS A CD2 1 
ATOM   1285 C CE1 . HIS A 1 172 ? -24.943 -17.662 -2.558  1.00 19.38 ? 197 HIS A CE1 1 
ATOM   1286 N NE2 . HIS A 1 172 ? -25.611 -17.822 -3.686  1.00 16.70 ? 197 HIS A NE2 1 
ATOM   1287 N N   . ALA A 1 173 ? -19.202 -18.892 -5.786  1.00 8.17  ? 198 ALA A N   1 
ATOM   1288 C CA  . ALA A 1 173 ? -17.810 -19.326 -5.771  1.00 9.10  ? 198 ALA A CA  1 
ATOM   1289 C C   . ALA A 1 173 ? -17.138 -18.961 -4.455  1.00 11.33 ? 198 ALA A C   1 
ATOM   1290 O O   . ALA A 1 173 ? -16.223 -19.665 -4.017  1.00 10.49 ? 198 ALA A O   1 
ATOM   1291 C CB  . ALA A 1 173 ? -17.035 -18.723 -6.946  1.00 10.75 ? 198 ALA A CB  1 
ATOM   1292 N N   . LEU A 1 174 ? -17.570 -17.871 -3.818  1.00 9.80  ? 199 LEU A N   1 
ATOM   1293 C CA  . LEU A 1 174 ? -17.039 -17.443 -2.530  1.00 8.79  ? 199 LEU A CA  1 
ATOM   1294 C C   . LEU A 1 174 ? -18.146 -17.527 -1.484  1.00 9.70  ? 199 LEU A C   1 
ATOM   1295 O O   . LEU A 1 174 ? -19.337 -17.556 -1.811  1.00 10.26 ? 199 LEU A O   1 
ATOM   1296 C CB  . LEU A 1 174 ? -16.551 -15.986 -2.605  1.00 8.69  ? 199 LEU A CB  1 
ATOM   1297 C CG  . LEU A 1 174 ? -15.328 -15.720 -3.477  1.00 11.58 ? 199 LEU A CG  1 
ATOM   1298 C CD1 . LEU A 1 174 ? -15.036 -14.232 -3.579  1.00 12.75 ? 199 LEU A CD1 1 
ATOM   1299 C CD2 . LEU A 1 174 ? -14.128 -16.472 -2.918  1.00 10.88 ? 199 LEU A CD2 1 
ATOM   1300 N N   . GLY A 1 175 ? -17.747 -17.569 -0.216  1.00 9.28  ? 200 GLY A N   1 
ATOM   1301 C CA  . GLY A 1 175 ? -18.721 -17.449 0.855   1.00 8.44  ? 200 GLY A CA  1 
ATOM   1302 C C   . GLY A 1 175 ? -19.369 -16.074 0.887   1.00 10.17 ? 200 GLY A C   1 
ATOM   1303 O O   . GLY A 1 175 ? -18.845 -15.092 0.352   1.00 10.31 ? 200 GLY A O   1 
ATOM   1304 N N   . GLU A 1 176 ? -20.526 -16.003 1.553   1.00 9.44  ? 201 GLU A N   1 
ATOM   1305 C CA  . GLU A 1 176 ? -21.343 -14.789 1.541   1.00 15.43 ? 201 GLU A CA  1 
ATOM   1306 C C   . GLU A 1 176 ? -20.542 -13.541 1.907   1.00 10.46 ? 201 GLU A C   1 
ATOM   1307 O O   . GLU A 1 176 ? -20.583 -12.536 1.182   1.00 13.12 ? 201 GLU A O   1 
ATOM   1308 C CB  . GLU A 1 176 ? -22.528 -14.939 2.497   1.00 17.11 ? 201 GLU A CB  1 
ATOM   1309 C CG  . GLU A 1 176 ? -23.455 -13.716 2.495   1.00 20.73 ? 201 GLU A CG  1 
ATOM   1310 C CD  . GLU A 1 176 ? -24.750 -13.943 3.254   1.00 34.70 ? 201 GLU A CD  1 
ATOM   1311 O OE1 . GLU A 1 176 ? -24.693 -13.953 4.503   1.00 28.09 ? 201 GLU A OE1 1 
ATOM   1312 O OE2 . GLU A 1 176 ? -25.817 -14.093 2.613   1.00 35.89 ? 201 GLU A OE2 1 
ATOM   1313 N N   . THR A 1 177 ? -19.830 -13.571 3.045   1.00 10.81 ? 202 THR A N   1 
ATOM   1314 C CA  . THR A 1 177 ? -19.088 -12.387 3.484   1.00 11.08 ? 202 THR A CA  1 
ATOM   1315 C C   . THR A 1 177 ? -17.979 -12.049 2.498   1.00 12.25 ? 202 THR A C   1 
ATOM   1316 O O   . THR A 1 177 ? -17.697 -10.870 2.236   1.00 11.08 ? 202 THR A O   1 
ATOM   1317 C CB  . THR A 1 177 ? -18.487 -12.637 4.874   1.00 13.79 ? 202 THR A CB  1 
ATOM   1318 O OG1 . THR A 1 177 ? -19.547 -12.827 5.808   1.00 21.04 ? 202 THR A OG1 1 
ATOM   1319 C CG2 . THR A 1 177 ? -17.648 -11.452 5.329   1.00 17.40 ? 202 THR A CG2 1 
ATOM   1320 N N   . GLN A 1 178 ? -17.350 -13.076 1.933   1.00 10.40 ? 203 GLN A N   1 
ATOM   1321 C CA  . GLN A 1 178 ? -16.217 -12.849 1.046   1.00 10.14 ? 203 GLN A CA  1 
ATOM   1322 C C   . GLN A 1 178 ? -16.671 -12.281 -0.291  1.00 9.58  ? 203 GLN A C   1 
ATOM   1323 O O   . GLN A 1 178 ? -16.025 -11.381 -0.840  1.00 9.51  ? 203 GLN A O   1 
ATOM   1324 C CB  . GLN A 1 178 ? -15.461 -14.162 0.871   1.00 8.03  ? 203 GLN A CB  1 
ATOM   1325 C CG  . GLN A 1 178 ? -14.772 -14.652 2.133   1.00 10.02 ? 203 GLN A CG  1 
ATOM   1326 C CD  . GLN A 1 178 ? -15.722 -15.272 3.165   1.00 11.34 ? 203 GLN A CD  1 
ATOM   1327 O OE1 . GLN A 1 178 ? -16.785 -15.813 2.832   1.00 9.52  ? 203 GLN A OE1 1 
ATOM   1328 N NE2 . GLN A 1 178 ? -15.332 -15.187 4.433   1.00 11.76 ? 203 GLN A NE2 1 
ATOM   1329 N N   . ARG A 1 179 ? -17.785 -12.788 -0.823  1.00 10.75 ? 204 ARG A N   1 
ATOM   1330 C CA  . ARG A 1 179 ? -18.390 -12.200 -2.013  1.00 9.00  ? 204 ARG A CA  1 
ATOM   1331 C C   . ARG A 1 179 ? -18.706 -10.731 -1.780  1.00 9.82  ? 204 ARG A C   1 
ATOM   1332 O O   . ARG A 1 179 ? -18.425 -9.887  -2.636  1.00 9.20  ? 204 ARG A O   1 
ATOM   1333 C CB  . ARG A 1 179 ? -19.650 -12.986 -2.383  1.00 10.09 ? 204 ARG A CB  1 
ATOM   1334 C CG  . ARG A 1 179 ? -20.371 -12.460 -3.625  1.00 11.58 ? 204 ARG A CG  1 
ATOM   1335 C CD  . ARG A 1 179 ? -21.620 -13.262 -3.939  1.00 13.08 ? 204 ARG A CD  1 
ATOM   1336 N NE  . ARG A 1 179 ? -22.655 -13.048 -2.933  1.00 17.61 ? 204 ARG A NE  1 
ATOM   1337 C CZ  . ARG A 1 179 ? -23.895 -13.520 -3.011  1.00 19.96 ? 204 ARG A CZ  1 
ATOM   1338 N NH1 . ARG A 1 179 ? -24.291 -14.265 -4.030  1.00 16.82 ? 204 ARG A NH1 1 
ATOM   1339 N NH2 . ARG A 1 179 ? -24.756 -13.245 -2.035  1.00 20.29 ? 204 ARG A NH2 1 
ATOM   1340 N N   . ALA A 1 180 ? -19.287 -10.407 -0.619  1.00 11.12 ? 205 ALA A N   1 
ATOM   1341 C CA  . ALA A 1 180 ? -19.621 -9.014  -0.332  1.00 11.08 ? 205 ALA A CA  1 
ATOM   1342 C C   . ALA A 1 180 ? -18.366 -8.163  -0.269  1.00 9.72  ? 205 ALA A C   1 
ATOM   1343 O O   . ALA A 1 180 ? -18.347 -7.028  -0.764  1.00 12.67 ? 205 ALA A O   1 
ATOM   1344 C CB  . ALA A 1 180 ? -20.419 -8.914  0.969   1.00 10.84 ? 205 ALA A CB  1 
ATOM   1345 N N   . GLN A 1 181 ? -17.297 -8.704  0.322   1.00 8.13  ? 206 GLN A N   1 
ATOM   1346 C CA  . GLN A 1 181 ? -16.043 -7.976  0.385   1.00 9.67  ? 206 GLN A CA  1 
ATOM   1347 C C   . GLN A 1 181 ? -15.482 -7.733  -1.011  1.00 10.99 ? 206 GLN A C   1 
ATOM   1348 O O   . GLN A 1 181 ? -15.001 -6.631  -1.309  1.00 10.43 ? 206 GLN A O   1 
ATOM   1349 C CB  . GLN A 1 181 ? -15.039 -8.746  1.245   1.00 9.83  ? 206 GLN A CB  1 
ATOM   1350 C CG  . GLN A 1 181 ? -13.688 -8.057  1.376   1.00 11.47 ? 206 GLN A CG  1 
ATOM   1351 C CD  . GLN A 1 181 ? -13.784 -6.710  2.047   1.00 10.59 ? 206 GLN A CD  1 
ATOM   1352 O OE1 . GLN A 1 181 ? -13.931 -5.669  1.390   1.00 16.69 ? 206 GLN A OE1 1 
ATOM   1353 N NE2 . GLN A 1 181 ? -13.692 -6.713  3.361   1.00 11.57 ? 206 GLN A NE2 1 
ATOM   1354 N N   . LEU A 1 182 ? -15.531 -8.746  -1.882  1.00 10.52 ? 207 LEU A N   1 
ATOM   1355 C CA  . LEU A 1 182 ? -15.042 -8.551  -3.240  1.00 10.91 ? 207 LEU A CA  1 
ATOM   1356 C C   . LEU A 1 182 ? -15.843 -7.467  -3.959  1.00 9.40  ? 207 LEU A C   1 
ATOM   1357 O O   . LEU A 1 182 ? -15.266 -6.584  -4.611  1.00 10.72 ? 207 LEU A O   1 
ATOM   1358 C CB  . LEU A 1 182 ? -15.080 -9.875  -4.008  1.00 10.20 ? 207 LEU A CB  1 
ATOM   1359 C CG  . LEU A 1 182 ? -14.597 -9.780  -5.456  1.00 8.79  ? 207 LEU A CG  1 
ATOM   1360 C CD1 . LEU A 1 182 ? -13.178 -9.247  -5.512  1.00 10.41 ? 207 LEU A CD1 1 
ATOM   1361 C CD2 . LEU A 1 182 ? -14.674 -11.130 -6.152  1.00 12.02 ? 207 LEU A CD2 1 
ATOM   1362 N N   . VAL A 1 183 ? -17.172 -7.498  -3.821  1.00 8.40  ? 208 VAL A N   1 
ATOM   1363 C CA  . VAL A 1 183 ? -18.025 -6.504  -4.469  1.00 8.47  ? 208 VAL A CA  1 
ATOM   1364 C C   . VAL A 1 183 ? -17.726 -5.104  -3.932  1.00 9.79  ? 208 VAL A C   1 
ATOM   1365 O O   . VAL A 1 183 ? -17.620 -4.136  -4.693  1.00 10.58 ? 208 VAL A O   1 
ATOM   1366 C CB  . VAL A 1 183 ? -19.509 -6.893  -4.326  1.00 9.89  ? 208 VAL A CB  1 
ATOM   1367 C CG1 . VAL A 1 183 ? -20.409 -5.716  -4.710  1.00 11.18 ? 208 VAL A CG1 1 
ATOM   1368 C CG2 . VAL A 1 183 ? -19.825 -8.126  -5.201  1.00 12.12 ? 208 VAL A CG2 1 
ATOM   1369 N N   . THR A 1 184 ? -17.596 -4.975  -2.612  1.00 8.77  ? 209 THR A N   1 
ATOM   1370 C CA  . THR A 1 184 ? -17.204 -3.696  -2.012  1.00 9.81  ? 209 THR A CA  1 
ATOM   1371 C C   . THR A 1 184 ? -15.902 -3.173  -2.601  1.00 9.88  ? 209 THR A C   1 
ATOM   1372 O O   . THR A 1 184 ? -15.787 -1.992  -2.941  1.00 11.08 ? 209 THR A O   1 
ATOM   1373 C CB  . THR A 1 184 ? -17.068 -3.891  -0.503  1.00 10.93 ? 209 THR A CB  1 
ATOM   1374 O OG1 . THR A 1 184 ? -18.357 -4.188  0.051   1.00 16.87 ? 209 THR A OG1 1 
ATOM   1375 C CG2 . THR A 1 184 ? -16.513 -2.632  0.168   1.00 13.32 ? 209 THR A CG2 1 
ATOM   1376 N N   . TRP A 1 185 ? -14.898 -4.034  -2.721  1.00 8.85  ? 210 TRP A N   1 
ATOM   1377 C CA  . TRP A 1 185 ? -13.628 -3.584  -3.277  1.00 8.33  ? 210 TRP A CA  1 
ATOM   1378 C C   . TRP A 1 185 ? -13.791 -3.104  -4.721  1.00 10.22 ? 210 TRP A C   1 
ATOM   1379 O O   . TRP A 1 185 ? -13.321 -2.019  -5.071  1.00 11.06 ? 210 TRP A O   1 
ATOM   1380 C CB  . TRP A 1 185 ? -12.583 -4.700  -3.182  1.00 9.37  ? 210 TRP A CB  1 
ATOM   1381 C CG  . TRP A 1 185 ? -11.943 -4.846  -1.821  1.00 13.32 ? 210 TRP A CG  1 
ATOM   1382 C CD1 . TRP A 1 185 ? -11.781 -3.869  -0.861  1.00 12.29 ? 210 TRP A CD1 1 
ATOM   1383 C CD2 . TRP A 1 185 ? -11.389 -6.043  -1.266  1.00 11.77 ? 210 TRP A CD2 1 
ATOM   1384 N NE1 . TRP A 1 185 ? -11.149 -4.396  0.244   1.00 11.95 ? 210 TRP A NE1 1 
ATOM   1385 C CE2 . TRP A 1 185 ? -10.890 -5.721  0.017   1.00 10.22 ? 210 TRP A CE2 1 
ATOM   1386 C CE3 . TRP A 1 185 ? -11.251 -7.356  -1.733  1.00 13.42 ? 210 TRP A CE3 1 
ATOM   1387 C CZ2 . TRP A 1 185 ? -10.288 -6.672  0.840   1.00 11.30 ? 210 TRP A CZ2 1 
ATOM   1388 C CZ3 . TRP A 1 185 ? -10.641 -8.297  -0.915  1.00 13.24 ? 210 TRP A CZ3 1 
ATOM   1389 C CH2 . TRP A 1 185 ? -10.170 -7.947  0.353   1.00 13.31 ? 210 TRP A CH2 1 
ATOM   1390 N N   . LEU A 1 186 ? -14.444 -3.910  -5.577  1.00 9.16  ? 211 LEU A N   1 
ATOM   1391 C CA  . LEU A 1 186 ? -14.638 -3.524  -6.980  1.00 8.45  ? 211 LEU A CA  1 
ATOM   1392 C C   . LEU A 1 186 ? -15.410 -2.219  -7.104  1.00 12.10 ? 211 LEU A C   1 
ATOM   1393 O O   . LEU A 1 186 ? -15.071 -1.368  -7.936  1.00 10.14 ? 211 LEU A O   1 
ATOM   1394 C CB  . LEU A 1 186 ? -15.367 -4.630  -7.739  1.00 9.04  ? 211 LEU A CB  1 
ATOM   1395 C CG  . LEU A 1 186 ? -14.649 -5.966  -7.898  1.00 9.43  ? 211 LEU A CG  1 
ATOM   1396 C CD1 . LEU A 1 186 ? -15.607 -6.977  -8.457  1.00 11.03 ? 211 LEU A CD1 1 
ATOM   1397 C CD2 . LEU A 1 186 ? -13.455 -5.819  -8.822  1.00 12.59 ? 211 LEU A CD2 1 
ATOM   1398 N N   . LYS A 1 187 ? -16.471 -2.053  -6.302  1.00 10.37 ? 212 LYS A N   1 
ATOM   1399 C CA  . LYS A 1 187 ? -17.268 -0.828  -6.354  1.00 10.14 ? 212 LYS A CA  1 
ATOM   1400 C C   . LYS A 1 187 ? -16.452 0.401   -5.967  1.00 10.89 ? 212 LYS A C   1 
ATOM   1401 O O   . LYS A 1 187 ? -16.772 1.517   -6.390  1.00 11.65 ? 212 LYS A O   1 
ATOM   1402 C CB  . LYS A 1 187 ? -18.498 -0.956  -5.450  1.00 10.02 ? 212 LYS A CB  1 
ATOM   1403 C CG  . LYS A 1 187 ? -19.650 -1.743  -6.047  1.00 11.77 ? 212 LYS A CG  1 
ATOM   1404 C CD  . LYS A 1 187 ? -20.792 -1.795  -5.034  1.00 11.70 ? 212 LYS A CD  1 
ATOM   1405 C CE  . LYS A 1 187 ? -21.977 -2.577  -5.580  1.00 14.34 ? 212 LYS A CE  1 
ATOM   1406 N NZ  . LYS A 1 187 ? -23.155 -2.467  -4.660  1.00 19.90 ? 212 LYS A NZ  1 
ATOM   1407 N N   . GLY A 1 188 ? -15.410 0.226   -5.162  1.00 7.85  ? 213 GLY A N   1 
ATOM   1408 C CA  . GLY A 1 188 ? -14.576 1.337   -4.745  1.00 9.32  ? 213 GLY A CA  1 
ATOM   1409 C C   . GLY A 1 188 ? -13.340 1.523   -5.596  1.00 9.29  ? 213 GLY A C   1 
ATOM   1410 O O   . GLY A 1 188 ? -12.404 2.227   -5.202  1.00 9.94  ? 213 GLY A O   1 
ATOM   1411 N N   . ASN A 1 189 ? -13.309 0.907   -6.769  1.00 8.78  ? 214 ASN A N   1 
ATOM   1412 C CA  . ASN A 1 189 ? -12.157 1.073   -7.643  1.00 7.84  ? 214 ASN A CA  1 
ATOM   1413 C C   . ASN A 1 189 ? -11.953 2.546   -7.991  1.00 10.23 ? 214 ASN A C   1 
ATOM   1414 O O   . ASN A 1 189 ? -12.916 3.289   -8.205  1.00 9.35  ? 214 ASN A O   1 
ATOM   1415 C CB  . ASN A 1 189 ? -12.378 0.275   -8.928  1.00 8.93  ? 214 ASN A CB  1 
ATOM   1416 C CG  . ASN A 1 189 ? -11.218 0.400   -9.872  1.00 10.58 ? 214 ASN A CG  1 
ATOM   1417 O OD1 . ASN A 1 189 ? -10.070 0.515   -9.437  1.00 12.58 ? 214 ASN A OD1 1 
ATOM   1418 N ND2 . ASN A 1 189 ? -11.497 0.410   -11.171 1.00 11.24 ? 214 ASN A ND2 1 
ATOM   1419 N N   . THR A 1 190 ? -10.685 2.977   -8.022  1.00 9.50  ? 215 THR A N   1 
ATOM   1420 C CA  . THR A 1 190 ? -10.358 4.360   -8.350  1.00 10.34 ? 215 THR A CA  1 
ATOM   1421 C C   . THR A 1 190 ? -10.017 4.570   -9.821  1.00 11.72 ? 215 THR A C   1 
ATOM   1422 O O   . THR A 1 190 ? -9.979  5.717   -10.269 1.00 11.65 ? 215 THR A O   1 
ATOM   1423 C CB  . THR A 1 190 ? -9.190  4.888   -7.490  1.00 9.61  ? 215 THR A CB  1 
ATOM   1424 O OG1 . THR A 1 190 ? -7.955  4.272   -7.886  1.00 10.81 ? 215 THR A OG1 1 
ATOM   1425 C CG2 . THR A 1 190 ? -9.439  4.652   -6.000  1.00 10.21 ? 215 THR A CG2 1 
ATOM   1426 N N   . THR A 1 191 ? -9.779  3.507   -10.583 1.00 10.65 ? 216 THR A N   1 
ATOM   1427 C CA  . THR A 1 191 ? -9.161  3.639   -11.898 1.00 11.01 ? 216 THR A CA  1 
ATOM   1428 C C   . THR A 1 191 ? -10.120 3.498   -13.077 1.00 10.62 ? 216 THR A C   1 
ATOM   1429 O O   . THR A 1 191 ? -9.652  3.516   -14.223 1.00 11.29 ? 216 THR A O   1 
ATOM   1430 C CB  . THR A 1 191 ? -8.052  2.596   -12.078 1.00 8.10  ? 216 THR A CB  1 
ATOM   1431 O OG1 . THR A 1 191 ? -8.647  1.290   -12.167 1.00 11.90 ? 216 THR A OG1 1 
ATOM   1432 C CG2 . THR A 1 191 ? -7.076  2.610   -10.925 1.00 11.47 ? 216 THR A CG2 1 
ATOM   1433 N N   . GLY A 1 192 ? -11.429 3.369   -12.847 1.00 8.55  ? 217 GLY A N   1 
ATOM   1434 C CA  . GLY A 1 192 ? -12.309 2.899   -13.904 1.00 9.82  ? 217 GLY A CA  1 
ATOM   1435 C C   . GLY A 1 192 ? -13.156 3.892   -14.679 1.00 11.46 ? 217 GLY A C   1 
ATOM   1436 O O   . GLY A 1 192 ? -13.848 3.476   -15.609 1.00 12.18 ? 217 GLY A O   1 
ATOM   1437 N N   . ALA A 1 193 ? -13.129 5.187   -14.350 1.00 9.72  ? 218 ALA A N   1 
ATOM   1438 C CA  . ALA A 1 193 ? -14.136 6.099   -14.889 1.00 9.63  ? 218 ALA A CA  1 
ATOM   1439 C C   . ALA A 1 193 ? -14.020 6.324   -16.391 1.00 12.70 ? 218 ALA A C   1 
ATOM   1440 O O   . ALA A 1 193 ? -14.978 6.810   -16.996 1.00 12.91 ? 218 ALA A O   1 
ATOM   1441 C CB  . ALA A 1 193 ? -14.084 7.451   -14.168 1.00 11.02 ? 218 ALA A CB  1 
ATOM   1442 N N   . ALA A 1 194 ? -12.884 6.005   -17.006 1.00 10.05 ? 219 ALA A N   1 
ATOM   1443 C CA  . ALA A 1 194 ? -12.694 6.218   -18.435 1.00 11.41 ? 219 ALA A CA  1 
ATOM   1444 C C   . ALA A 1 194 ? -12.965 4.971   -19.256 1.00 11.60 ? 219 ALA A C   1 
ATOM   1445 O O   . ALA A 1 194 ? -12.898 5.028   -20.489 1.00 12.58 ? 219 ALA A O   1 
ATOM   1446 C CB  . ALA A 1 194 ? -11.270 6.727   -18.721 1.00 10.91 ? 219 ALA A CB  1 
ATOM   1447 N N   . SER A 1 195 ? -13.274 3.851   -18.610 1.00 11.38 ? 220 SER A N   1 
ATOM   1448 C CA  . SER A 1 195 ? -13.371 2.586   -19.328 1.00 9.51  ? 220 SER A CA  1 
ATOM   1449 C C   . SER A 1 195 ? -14.843 2.195   -19.466 1.00 10.28 ? 220 SER A C   1 
ATOM   1450 O O   . SER A 1 195 ? -15.633 2.995   -19.979 1.00 9.84  ? 220 SER A O   1 
ATOM   1451 C CB  . SER A 1 195 ? -12.452 1.540   -18.687 1.00 10.19 ? 220 SER A CB  1 
ATOM   1452 O OG  . SER A 1 195 ? -11.121 2.055   -18.647 1.00 11.10 ? 220 SER A OG  1 
ATOM   1453 N N   . ILE A 1 196 ? -15.242 1.007   -18.994 1.00 11.26 ? 221 ILE A N   1 
ATOM   1454 C CA  . ILE A 1 196 ? -16.626 0.564   -19.180 1.00 14.50 ? 221 ILE A CA  1 
ATOM   1455 C C   . ILE A 1 196 ? -17.613 1.610   -18.653 1.00 10.86 ? 221 ILE A C   1 
ATOM   1456 O O   . ILE A 1 196 ? -18.592 1.956   -19.333 1.00 11.61 ? 221 ILE A O   1 
ATOM   1457 C CB  . ILE A 1 196 ? -16.839 -0.835  -18.565 1.00 9.55  ? 221 ILE A CB  1 
ATOM   1458 C CG1 . ILE A 1 196 ? -16.192 -1.898  -19.460 1.00 9.93  ? 221 ILE A CG1 1 
ATOM   1459 C CG2 . ILE A 1 196 ? -18.312 -1.125  -18.417 1.00 11.23 ? 221 ILE A CG2 1 
ATOM   1460 C CD1 . ILE A 1 196 ? -16.117 -3.321  -18.837 1.00 9.63  ? 221 ILE A CD1 1 
ATOM   1461 N N   A ARG A 1 197 ? -17.353 2.148   -17.456 0.54 10.50 ? 222 ARG A N   1 
ATOM   1462 N N   B ARG A 1 197 ? -17.336 2.148   -17.458 0.46 10.51 ? 222 ARG A N   1 
ATOM   1463 C CA  A ARG A 1 197 ? -18.264 3.117   -16.842 0.54 12.06 ? 222 ARG A CA  1 
ATOM   1464 C CA  B ARG A 1 197 ? -18.200 3.133   -16.806 0.46 12.16 ? 222 ARG A CA  1 
ATOM   1465 C C   A ARG A 1 197 ? -18.579 4.273   -17.777 0.54 13.68 ? 222 ARG A C   1 
ATOM   1466 C C   B ARG A 1 197 ? -18.550 4.283   -17.736 0.46 13.70 ? 222 ARG A C   1 
ATOM   1467 O O   A ARG A 1 197 ? -19.708 4.776   -17.794 0.54 14.52 ? 222 ARG A O   1 
ATOM   1468 O O   B ARG A 1 197 ? -19.682 4.783   -17.720 0.46 14.48 ? 222 ARG A O   1 
ATOM   1469 C CB  A ARG A 1 197 ? -17.646 3.691   -15.563 0.54 13.48 ? 222 ARG A CB  1 
ATOM   1470 C CB  B ARG A 1 197 ? -17.471 3.696   -15.577 0.46 13.32 ? 222 ARG A CB  1 
ATOM   1471 C CG  A ARG A 1 197 ? -17.554 2.724   -14.417 0.54 23.61 ? 222 ARG A CG  1 
ATOM   1472 C CG  B ARG A 1 197 ? -18.357 4.077   -14.404 0.46 19.00 ? 222 ARG A CG  1 
ATOM   1473 C CD  A ARG A 1 197 ? -16.637 3.274   -13.353 0.54 19.12 ? 222 ARG A CD  1 
ATOM   1474 C CD  B ARG A 1 197 ? -17.514 4.296   -13.159 0.46 15.60 ? 222 ARG A CD  1 
ATOM   1475 N NE  A ARG A 1 197 ? -16.176 2.234   -12.448 0.54 23.22 ? 222 ARG A NE  1 
ATOM   1476 N NE  B ARG A 1 197 ? -17.685 5.633   -12.602 0.46 26.58 ? 222 ARG A NE  1 
ATOM   1477 C CZ  A ARG A 1 197 ? -16.627 2.060   -11.216 0.54 15.34 ? 222 ARG A CZ  1 
ATOM   1478 C CZ  B ARG A 1 197 ? -18.479 5.919   -11.579 0.46 17.00 ? 222 ARG A CZ  1 
ATOM   1479 N NH1 A ARG A 1 197 ? -17.522 2.880   -10.687 0.54 19.39 ? 222 ARG A NH1 1 
ATOM   1480 N NH1 B ARG A 1 197 ? -19.149 4.974   -10.940 0.46 25.38 ? 222 ARG A NH1 1 
ATOM   1481 N NH2 A ARG A 1 197 ? -16.161 1.048   -10.494 0.54 18.68 ? 222 ARG A NH2 1 
ATOM   1482 N NH2 B ARG A 1 197 ? -18.607 7.183   -11.190 0.46 21.52 ? 222 ARG A NH2 1 
ATOM   1483 N N   . ALA A 1 198 ? -17.585 4.731   -18.541 1.00 12.34 ? 223 ALA A N   1 
ATOM   1484 C CA  . ALA A 1 198 ? -17.788 5.910   -19.374 1.00 14.55 ? 223 ALA A CA  1 
ATOM   1485 C C   . ALA A 1 198 ? -18.817 5.683   -20.471 1.00 15.29 ? 223 ALA A C   1 
ATOM   1486 O O   . ALA A 1 198 ? -19.340 6.659   -21.024 1.00 16.36 ? 223 ALA A O   1 
ATOM   1487 C CB  . ALA A 1 198 ? -16.464 6.370   -19.983 1.00 10.91 ? 223 ALA A CB  1 
ATOM   1488 N N   . GLY A 1 199 ? -19.107 4.432   -20.812 1.00 12.73 ? 224 GLY A N   1 
ATOM   1489 C CA  . GLY A 1 199 ? -20.081 4.136   -21.838 1.00 10.80 ? 224 GLY A CA  1 
ATOM   1490 C C   . GLY A 1 199 ? -21.467 3.841   -21.321 1.00 13.15 ? 224 GLY A C   1 
ATOM   1491 O O   . GLY A 1 199 ? -22.344 3.509   -22.122 1.00 15.98 ? 224 GLY A O   1 
ATOM   1492 N N   . LEU A 1 200 ? -21.697 3.953   -20.009 1.00 14.97 ? 225 LEU A N   1 
ATOM   1493 C CA  . LEU A 1 200 ? -22.950 3.591   -19.369 1.00 13.44 ? 225 LEU A CA  1 
ATOM   1494 C C   . LEU A 1 200 ? -23.632 4.818   -18.776 1.00 13.28 ? 225 LEU A C   1 
ATOM   1495 O O   . LEU A 1 200 ? -22.965 5.796   -18.423 1.00 17.48 ? 225 LEU A O   1 
ATOM   1496 C CB  . LEU A 1 200 ? -22.702 2.572   -18.248 1.00 14.47 ? 225 LEU A CB  1 
ATOM   1497 C CG  . LEU A 1 200 ? -22.034 1.285   -18.727 1.00 16.51 ? 225 LEU A CG  1 
ATOM   1498 C CD1 . LEU A 1 200 ? -21.839 0.355   -17.542 1.00 17.60 ? 225 LEU A CD1 1 
ATOM   1499 C CD2 . LEU A 1 200 ? -22.865 0.635   -19.828 1.00 16.34 ? 225 LEU A CD2 1 
ATOM   1500 N N   . PRO A 1 201 ? -24.961 4.798   -18.658 1.00 16.04 ? 226 PRO A N   1 
ATOM   1501 C CA  . PRO A 1 201 ? -25.656 5.900   -17.984 1.00 18.41 ? 226 PRO A CA  1 
ATOM   1502 C C   . PRO A 1 201 ? -25.092 6.104   -16.588 1.00 15.93 ? 226 PRO A C   1 
ATOM   1503 O O   . PRO A 1 201 ? -24.798 5.146   -15.871 1.00 19.01 ? 226 PRO A O   1 
ATOM   1504 C CB  . PRO A 1 201 ? -27.114 5.420   -17.925 1.00 14.90 ? 226 PRO A CB  1 
ATOM   1505 C CG  . PRO A 1 201 ? -27.237 4.417   -19.007 1.00 14.36 ? 226 PRO A CG  1 
ATOM   1506 C CD  . PRO A 1 201 ? -25.883 3.763   -19.148 1.00 14.85 ? 226 PRO A CD  1 
ATOM   1507 N N   . THR A 1 202 ? -24.946 7.371   -16.201 1.00 18.46 ? 227 THR A N   1 
ATOM   1508 C CA  . THR A 1 202 ? -24.323 7.665   -14.920 1.00 17.21 ? 227 THR A CA  1 
ATOM   1509 C C   . THR A 1 202 ? -25.132 7.137   -13.744 1.00 21.56 ? 227 THR A C   1 
ATOM   1510 O O   . THR A 1 202 ? -24.569 6.936   -12.663 1.00 25.30 ? 227 THR A O   1 
ATOM   1511 C CB  . THR A 1 202 ? -24.046 9.164   -14.788 1.00 26.25 ? 227 THR A CB  1 
ATOM   1512 O OG1 . THR A 1 202 ? -25.253 9.890   -15.036 1.00 39.65 ? 227 THR A OG1 1 
ATOM   1513 C CG2 . THR A 1 202 ? -22.980 9.595   -15.794 1.00 30.08 ? 227 THR A CG2 1 
ATOM   1514 N N   . SER A 1 203 ? -26.426 6.866   -13.936 1.00 15.68 ? 228 SER A N   1 
ATOM   1515 C CA  . SER A 1 203 ? -27.256 6.385   -12.836 1.00 22.94 ? 228 SER A CA  1 
ATOM   1516 C C   . SER A 1 203 ? -26.966 4.935   -12.458 1.00 20.78 ? 228 SER A C   1 
ATOM   1517 O O   . SER A 1 203 ? -27.370 4.500   -11.373 1.00 20.77 ? 228 SER A O   1 
ATOM   1518 C CB  . SER A 1 203 ? -28.736 6.555   -13.181 1.00 22.44 ? 228 SER A CB  1 
ATOM   1519 O OG  . SER A 1 203 ? -29.125 5.690   -14.237 1.00 19.63 ? 228 SER A OG  1 
ATOM   1520 N N   . TRP A 1 204 ? -26.287 4.178   -13.317 1.00 18.00 ? 229 TRP A N   1 
ATOM   1521 C CA  . TRP A 1 204 ? -26.004 2.777   -13.038 1.00 17.93 ? 229 TRP A CA  1 
ATOM   1522 C C   . TRP A 1 204 ? -24.806 2.646   -12.108 1.00 16.97 ? 229 TRP A C   1 
ATOM   1523 O O   . TRP A 1 204 ? -23.913 3.490   -12.094 1.00 18.93 ? 229 TRP A O   1 
ATOM   1524 C CB  . TRP A 1 204 ? -25.707 2.021   -14.334 1.00 14.82 ? 229 TRP A CB  1 
ATOM   1525 C CG  . TRP A 1 204 ? -26.835 2.002   -15.345 1.00 14.23 ? 229 TRP A CG  1 
ATOM   1526 C CD1 . TRP A 1 204 ? -27.953 2.791   -15.354 1.00 19.75 ? 229 TRP A CD1 1 
ATOM   1527 C CD2 . TRP A 1 204 ? -26.923 1.172   -16.510 1.00 13.97 ? 229 TRP A CD2 1 
ATOM   1528 N NE1 . TRP A 1 204 ? -28.739 2.485   -16.436 1.00 19.11 ? 229 TRP A NE1 1 
ATOM   1529 C CE2 . TRP A 1 204 ? -28.129 1.501   -17.166 1.00 15.81 ? 229 TRP A CE2 1 
ATOM   1530 C CE3 . TRP A 1 204 ? -26.106 0.175   -17.059 1.00 17.11 ? 229 TRP A CE3 1 
ATOM   1531 C CZ2 . TRP A 1 204 ? -28.542 0.862   -18.339 1.00 19.37 ? 229 TRP A CZ2 1 
ATOM   1532 C CZ3 . TRP A 1 204 ? -26.516 -0.456  -18.230 1.00 19.86 ? 229 TRP A CZ3 1 
ATOM   1533 C CH2 . TRP A 1 204 ? -27.726 -0.111  -18.853 1.00 21.62 ? 229 TRP A CH2 1 
ATOM   1534 N N   . THR A 1 205 ? -24.802 1.585   -11.310 1.00 13.05 ? 230 THR A N   1 
ATOM   1535 C CA  . THR A 1 205 ? -23.708 1.313   -10.381 1.00 11.64 ? 230 THR A CA  1 
ATOM   1536 C C   . THR A 1 205 ? -22.763 0.286   -10.981 1.00 12.64 ? 230 THR A C   1 
ATOM   1537 O O   . THR A 1 205 ? -23.205 -0.762  -11.458 1.00 15.32 ? 230 THR A O   1 
ATOM   1538 C CB  . THR A 1 205 ? -24.229 0.801   -9.040  1.00 14.51 ? 230 THR A CB  1 
ATOM   1539 O OG1 . THR A 1 205 ? -25.135 1.754   -8.471  1.00 23.83 ? 230 THR A OG1 1 
ATOM   1540 C CG2 . THR A 1 205 ? -23.067 0.512   -8.069  1.00 14.66 ? 230 THR A CG2 1 
ATOM   1541 N N   . VAL A 1 206 ? -21.463 0.579   -10.927 1.00 12.18 ? 231 VAL A N   1 
ATOM   1542 C CA  . VAL A 1 206 ? -20.432 -0.268  -11.522 1.00 10.88 ? 231 VAL A CA  1 
ATOM   1543 C C   . VAL A 1 206 ? -19.370 -0.619  -10.482 1.00 9.49  ? 231 VAL A C   1 
ATOM   1544 O O   . VAL A 1 206 ? -18.933 0.239   -9.703  1.00 14.12 ? 231 VAL A O   1 
ATOM   1545 C CB  . VAL A 1 206 ? -19.777 0.431   -12.738 1.00 11.84 ? 231 VAL A CB  1 
ATOM   1546 C CG1 . VAL A 1 206 ? -18.689 -0.451  -13.338 1.00 14.61 ? 231 VAL A CG1 1 
ATOM   1547 C CG2 . VAL A 1 206 ? -20.819 0.759   -13.785 1.00 12.91 ? 231 VAL A CG2 1 
ATOM   1548 N N   . GLY A 1 207 ? -18.950 -1.877  -10.486 1.00 10.84 ? 232 GLY A N   1 
ATOM   1549 C CA  . GLY A 1 207 ? -17.684 -2.284  -9.882  1.00 11.12 ? 232 GLY A CA  1 
ATOM   1550 C C   . GLY A 1 207 ? -16.805 -2.874  -10.967 1.00 7.97  ? 232 GLY A C   1 
ATOM   1551 O O   . GLY A 1 207 ? -17.284 -3.635  -11.804 1.00 11.81 ? 232 GLY A O   1 
ATOM   1552 N N   . ASP A 1 208 ? -15.530 -2.492  -10.990 1.00 9.59  ? 233 ASP A N   1 
ATOM   1553 C CA  . ASP A 1 208 ? -14.708 -2.925  -12.114 1.00 11.71 ? 233 ASP A CA  1 
ATOM   1554 C C   . ASP A 1 208 ? -13.244 -3.060  -11.718 1.00 9.98  ? 233 ASP A C   1 
ATOM   1555 O O   . ASP A 1 208 ? -12.811 -2.592  -10.658 1.00 9.97  ? 233 ASP A O   1 
ATOM   1556 C CB  . ASP A 1 208 ? -14.856 -1.978  -13.316 1.00 12.05 ? 233 ASP A CB  1 
ATOM   1557 C CG  . ASP A 1 208 ? -13.941 -0.758  -13.213 1.00 12.12 ? 233 ASP A CG  1 
ATOM   1558 O OD1 . ASP A 1 208 ? -14.158 0.070   -12.302 1.00 12.52 ? 233 ASP A OD1 1 
ATOM   1559 O OD2 . ASP A 1 208 ? -12.989 -0.638  -14.021 1.00 12.13 ? 233 ASP A OD2 1 
ATOM   1560 N N   . LYS A 1 209 ? -12.482 -3.737  -12.581 1.00 8.90  ? 234 LYS A N   1 
ATOM   1561 C CA  . LYS A 1 209 ? -11.020 -3.730  -12.505 1.00 8.84  ? 234 LYS A CA  1 
ATOM   1562 C C   . LYS A 1 209 ? -10.457 -3.544  -13.909 1.00 8.43  ? 234 LYS A C   1 
ATOM   1563 O O   . LYS A 1 209 ? -10.762 -4.342  -14.806 1.00 9.22  ? 234 LYS A O   1 
ATOM   1564 C CB  . LYS A 1 209 ? -10.486 -5.042  -11.925 1.00 10.11 ? 234 LYS A CB  1 
ATOM   1565 C CG  . LYS A 1 209 ? -8.956  -5.125  -11.847 1.00 10.15 ? 234 LYS A CG  1 
ATOM   1566 C CD  . LYS A 1 209 ? -8.428  -4.237  -10.717 1.00 9.65  ? 234 LYS A CD  1 
ATOM   1567 C CE  . LYS A 1 209 ? -6.919  -4.006  -10.812 1.00 9.93  ? 234 LYS A CE  1 
ATOM   1568 N NZ  . LYS A 1 209 ? -6.623  -2.921  -11.804 1.00 10.57 ? 234 LYS A NZ  1 
ATOM   1569 N N   . THR A 1 210 ? -9.618  -2.523  -14.082 1.00 10.31 ? 235 THR A N   1 
ATOM   1570 C CA  . THR A 1 210 ? -8.963  -2.188  -15.338 1.00 7.91  ? 235 THR A CA  1 
ATOM   1571 C C   . THR A 1 210 ? -7.643  -2.950  -15.499 1.00 9.96  ? 235 THR A C   1 
ATOM   1572 O O   . THR A 1 210 ? -7.121  -3.572  -14.570 1.00 10.88 ? 235 THR A O   1 
ATOM   1573 C CB  . THR A 1 210 ? -8.710  -0.679  -15.406 1.00 8.66  ? 235 THR A CB  1 
ATOM   1574 O OG1 . THR A 1 210 ? -8.047  -0.282  -14.204 1.00 11.20 ? 235 THR A OG1 1 
ATOM   1575 C CG2 . THR A 1 210 ? -10.015 0.098   -15.511 1.00 13.11 ? 235 THR A CG2 1 
ATOM   1576 N N   . GLY A 1 211 ? -7.084  -2.873  -16.704 1.00 10.10 ? 236 GLY A N   1 
ATOM   1577 C CA  . GLY A 1 211 ? -5.741  -3.371  -16.952 1.00 11.79 ? 236 GLY A CA  1 
ATOM   1578 C C   . GLY A 1 211 ? -5.145  -2.699  -18.166 1.00 9.09  ? 236 GLY A C   1 
ATOM   1579 O O   . GLY A 1 211 ? -5.866  -2.230  -19.052 1.00 10.24 ? 236 GLY A O   1 
ATOM   1580 N N   . SER A 1 212 ? -3.813  -2.645  -18.201 1.00 10.53 ? 237 SER A N   1 
ATOM   1581 C CA  . SER A 1 212 ? -3.082  -2.072  -19.321 1.00 10.20 ? 237 SER A CA  1 
ATOM   1582 C C   . SER A 1 212 ? -1.784  -2.849  -19.498 1.00 9.12  ? 237 SER A C   1 
ATOM   1583 O O   . SER A 1 212 ? -1.242  -3.402  -18.534 1.00 11.03 ? 237 SER A O   1 
ATOM   1584 C CB  . SER A 1 212 ? -2.763  -0.594  -19.049 1.00 18.32 ? 237 SER A CB  1 
ATOM   1585 O OG  . SER A 1 212 ? -1.525  -0.214  -19.624 1.00 33.38 ? 237 SER A OG  1 
ATOM   1586 N N   . GLY A 1 213 ? -1.281  -2.884  -20.727 1.00 11.04 ? 238 GLY A N   1 
ATOM   1587 C CA  . GLY A 1 213 ? -0.004  -3.534  -20.941 1.00 11.14 ? 238 GLY A CA  1 
ATOM   1588 C C   . GLY A 1 213 ? 0.640   -3.100  -22.237 1.00 10.89 ? 238 GLY A C   1 
ATOM   1589 O O   . GLY A 1 213 ? 0.190   -2.160  -22.891 1.00 14.50 ? 238 GLY A O   1 
ATOM   1590 N N   . ASP A 1 214 ? 1.707   -3.807  -22.610 1.00 13.22 ? 240 ASP A N   1 
ATOM   1591 C CA  . ASP A 1 214 ? 2.321   -3.548  -23.905 1.00 15.71 ? 240 ASP A CA  1 
ATOM   1592 C C   . ASP A 1 214 ? 1.332   -3.897  -25.022 1.00 15.82 ? 240 ASP A C   1 
ATOM   1593 O O   . ASP A 1 214 ? 0.250   -4.451  -24.792 1.00 13.23 ? 240 ASP A O   1 
ATOM   1594 C CB  . ASP A 1 214 ? 3.606   -4.365  -24.069 1.00 12.13 ? 240 ASP A CB  1 
ATOM   1595 C CG  . ASP A 1 214 ? 4.753   -3.873  -23.190 1.00 18.34 ? 240 ASP A CG  1 
ATOM   1596 O OD1 . ASP A 1 214 ? 4.649   -2.793  -22.565 1.00 20.79 ? 240 ASP A OD1 1 
ATOM   1597 O OD2 . ASP A 1 214 ? 5.768   -4.590  -23.113 1.00 17.95 ? 240 ASP A OD2 1 
ATOM   1598 N N   . TYR A 1 215 ? 1.715   -3.557  -26.252 1.00 15.81 ? 241 TYR A N   1 
ATOM   1599 C CA  . TYR A 1 215 ? 0.841   -3.707  -27.418 1.00 10.90 ? 241 TYR A CA  1 
ATOM   1600 C C   . TYR A 1 215 ? -0.450  -2.907  -27.252 1.00 14.53 ? 241 TYR A C   1 
ATOM   1601 O O   . TYR A 1 215 ? -1.498  -3.267  -27.793 1.00 13.15 ? 241 TYR A O   1 
ATOM   1602 C CB  . TYR A 1 215 ? 0.612   -5.182  -27.805 1.00 13.27 ? 241 TYR A CB  1 
ATOM   1603 C CG  . TYR A 1 215 ? 1.877   -5.816  -28.349 1.00 13.25 ? 241 TYR A CG  1 
ATOM   1604 C CD1 . TYR A 1 215 ? 2.828   -6.363  -27.496 1.00 12.24 ? 241 TYR A CD1 1 
ATOM   1605 C CD2 . TYR A 1 215 ? 2.137   -5.819  -29.710 1.00 15.61 ? 241 TYR A CD2 1 
ATOM   1606 C CE1 . TYR A 1 215 ? 4.007   -6.909  -27.981 1.00 15.17 ? 241 TYR A CE1 1 
ATOM   1607 C CE2 . TYR A 1 215 ? 3.317   -6.371  -30.213 1.00 15.71 ? 241 TYR A CE2 1 
ATOM   1608 C CZ  . TYR A 1 215 ? 4.243   -6.908  -29.344 1.00 18.76 ? 241 TYR A CZ  1 
ATOM   1609 O OH  . TYR A 1 215 ? 5.408   -7.453  -29.831 1.00 19.92 ? 241 TYR A OH  1 
ATOM   1610 N N   . GLY A 1 216 ? -0.357  -1.776  -26.547 1.00 10.29 ? 242 GLY A N   1 
ATOM   1611 C CA  . GLY A 1 216 ? -1.509  -0.923  -26.304 1.00 11.84 ? 242 GLY A CA  1 
ATOM   1612 C C   . GLY A 1 216 ? -2.689  -1.653  -25.693 1.00 11.60 ? 242 GLY A C   1 
ATOM   1613 O O   . GLY A 1 216 ? -3.844  -1.299  -25.938 1.00 11.85 ? 242 GLY A O   1 
ATOM   1614 N N   . THR A 1 217 ? -2.406  -2.673  -24.891 1.00 11.57 ? 243 THR A N   1 
ATOM   1615 C CA  . THR A 1 217 ? -3.471  -3.493  -24.327 1.00 10.84 ? 243 THR A CA  1 
ATOM   1616 C C   . THR A 1 217 ? -4.237  -2.674  -23.308 1.00 10.28 ? 243 THR A C   1 
ATOM   1617 O O   . THR A 1 217 ? -3.638  -2.048  -22.430 1.00 10.68 ? 243 THR A O   1 
ATOM   1618 C CB  . THR A 1 217 ? -2.883  -4.748  -23.688 1.00 11.62 ? 243 THR A CB  1 
ATOM   1619 O OG1 . THR A 1 217 ? -2.253  -5.526  -24.708 1.00 12.02 ? 243 THR A OG1 1 
ATOM   1620 C CG2 . THR A 1 217 ? -3.976  -5.590  -23.043 1.00 12.22 ? 243 THR A CG2 1 
ATOM   1621 N N   . THR A 1 218 ? -5.565  -2.676  -23.436 1.00 9.43  ? 244 THR A N   1 
ATOM   1622 C CA  . THR A 1 218 ? -6.447  -1.826  -22.640 1.00 10.71 ? 244 THR A CA  1 
ATOM   1623 C C   . THR A 1 218 ? -7.646  -2.680  -22.268 1.00 9.17  ? 244 THR A C   1 
ATOM   1624 O O   . THR A 1 218 ? -8.408  -3.064  -23.151 1.00 9.25  ? 244 THR A O   1 
ATOM   1625 C CB  . THR A 1 218 ? -6.907  -0.620  -23.465 1.00 10.37 ? 244 THR A CB  1 
ATOM   1626 O OG1 . THR A 1 218 ? -5.780  -0.007  -24.105 1.00 12.40 ? 244 THR A OG1 1 
ATOM   1627 C CG2 . THR A 1 218 ? -7.565  0.416   -22.586 1.00 12.73 ? 244 THR A CG2 1 
ATOM   1628 N N   . ASN A 1 219 ? -7.819  -2.968  -20.978 1.00 10.49 ? 245 ASN A N   1 
ATOM   1629 C CA  . ASN A 1 219 ? -8.803  -3.941  -20.524 1.00 8.86  ? 245 ASN A CA  1 
ATOM   1630 C C   . ASN A 1 219 ? -9.689  -3.374  -19.425 1.00 10.37 ? 245 ASN A C   1 
ATOM   1631 O O   . ASN A 1 219 ? -9.317  -2.442  -18.710 1.00 9.24  ? 245 ASN A O   1 
ATOM   1632 C CB  . ASN A 1 219 ? -8.111  -5.171  -19.929 1.00 8.78  ? 245 ASN A CB  1 
ATOM   1633 C CG  . ASN A 1 219 ? -7.286  -5.949  -20.938 1.00 9.21  ? 245 ASN A CG  1 
ATOM   1634 O OD1 . ASN A 1 219 ? -7.524  -5.888  -22.148 1.00 10.38 ? 245 ASN A OD1 1 
ATOM   1635 N ND2 . ASN A 1 219 ? -6.337  -6.726  -20.434 1.00 11.19 ? 245 ASN A ND2 1 
ATOM   1636 N N   . ASP A 1 220 ? -10.843 -4.010  -19.244 1.00 10.61 ? 246 ASP A N   1 
ATOM   1637 C CA  . ASP A 1 220 ? -11.718 -3.692  -18.120 1.00 8.93  ? 246 ASP A CA  1 
ATOM   1638 C C   . ASP A 1 220 ? -12.690 -4.847  -17.945 1.00 9.89  ? 246 ASP A C   1 
ATOM   1639 O O   . ASP A 1 220 ? -13.171 -5.409  -18.934 1.00 9.66  ? 246 ASP A O   1 
ATOM   1640 C CB  . ASP A 1 220 ? -12.479 -2.376  -18.355 1.00 8.51  ? 246 ASP A CB  1 
ATOM   1641 C CG  . ASP A 1 220 ? -13.039 -1.767  -17.066 1.00 11.17 ? 246 ASP A CG  1 
ATOM   1642 O OD1 . ASP A 1 220 ? -12.628 -2.139  -15.957 1.00 8.73  ? 246 ASP A OD1 1 
ATOM   1643 O OD2 . ASP A 1 220 ? -13.899 -0.886  -17.160 1.00 11.03 ? 246 ASP A OD2 1 
ATOM   1644 N N   . ILE A 1 221 ? -12.946 -5.233  -16.693 1.00 8.57  ? 247 ILE A N   1 
ATOM   1645 C CA  . ILE A 1 221 ? -13.949 -6.249  -16.383 1.00 8.99  ? 247 ILE A CA  1 
ATOM   1646 C C   . ILE A 1 221 ? -14.858 -5.687  -15.302 1.00 8.86  ? 247 ILE A C   1 
ATOM   1647 O O   . ILE A 1 221 ? -14.376 -5.061  -14.352 1.00 11.18 ? 247 ILE A O   1 
ATOM   1648 C CB  . ILE A 1 221 ? -13.349 -7.634  -16.010 1.00 9.45  ? 247 ILE A CB  1 
ATOM   1649 C CG1 . ILE A 1 221 ? -12.644 -7.660  -14.641 1.00 9.78  ? 247 ILE A CG1 1 
ATOM   1650 C CG2 . ILE A 1 221 ? -12.396 -8.118  -17.076 1.00 11.03 ? 247 ILE A CG2 1 
ATOM   1651 C CD1 . ILE A 1 221 ? -12.149 -9.063  -14.267 1.00 10.47 ? 247 ILE A CD1 1 
ATOM   1652 N N   . ALA A 1 222 ? -16.169 -5.849  -15.474 1.00 8.57  ? 248 ALA A N   1 
ATOM   1653 C CA  . ALA A 1 222 ? -17.105 -5.093  -14.655 1.00 8.61  ? 248 ALA A CA  1 
ATOM   1654 C C   . ALA A 1 222 ? -18.363 -5.889  -14.325 1.00 12.48 ? 248 ALA A C   1 
ATOM   1655 O O   . ALA A 1 222 ? -18.858 -6.694  -15.122 1.00 10.13 ? 248 ALA A O   1 
ATOM   1656 C CB  . ALA A 1 222 ? -17.533 -3.800  -15.356 1.00 8.99  ? 248 ALA A CB  1 
ATOM   1657 N N   . VAL A 1 223 ? -18.901 -5.616  -13.142 1.00 11.06 ? 249 VAL A N   1 
ATOM   1658 C CA  . VAL A 1 223 ? -20.253 -6.004  -12.785 1.00 9.53  ? 249 VAL A CA  1 
ATOM   1659 C C   . VAL A 1 223 ? -21.051 -4.717  -12.663 1.00 8.94  ? 249 VAL A C   1 
ATOM   1660 O O   . VAL A 1 223 ? -20.573 -3.733  -12.083 1.00 11.96 ? 249 VAL A O   1 
ATOM   1661 C CB  . VAL A 1 223 ? -20.277 -6.807  -11.477 1.00 11.94 ? 249 VAL A CB  1 
ATOM   1662 C CG1 . VAL A 1 223 ? -21.708 -7.239  -11.124 1.00 15.27 ? 249 VAL A CG1 1 
ATOM   1663 C CG2 . VAL A 1 223 ? -19.365 -7.994  -11.585 1.00 15.05 ? 249 VAL A CG2 1 
ATOM   1664 N N   . ILE A 1 224 ? -22.241 -4.707  -13.247 1.00 10.76 ? 250 ILE A N   1 
ATOM   1665 C CA  . ILE A 1 224 ? -23.011 -3.495  -13.481 1.00 10.69 ? 250 ILE A CA  1 
ATOM   1666 C C   . ILE A 1 224 ? -24.407 -3.711  -12.928 1.00 11.91 ? 250 ILE A C   1 
ATOM   1667 O O   . ILE A 1 224 ? -25.034 -4.737  -13.204 1.00 13.15 ? 250 ILE A O   1 
ATOM   1668 C CB  . ILE A 1 224 ? -23.102 -3.193  -14.988 1.00 10.14 ? 250 ILE A CB  1 
ATOM   1669 C CG1 . ILE A 1 224 ? -21.712 -3.049  -15.617 1.00 13.20 ? 250 ILE A CG1 1 
ATOM   1670 C CG2 . ILE A 1 224 ? -23.991 -1.967  -15.236 1.00 11.78 ? 250 ILE A CG2 1 
ATOM   1671 C CD1 . ILE A 1 224 ? -21.701 -3.304  -17.129 1.00 13.89 ? 250 ILE A CD1 1 
ATOM   1672 N N   . TRP A 1 225 ? -24.899 -2.745  -12.159 1.00 12.04 ? 251 TRP A N   1 
ATOM   1673 C CA  . TRP A 1 225 ? -26.260 -2.775  -11.634 1.00 12.33 ? 251 TRP A CA  1 
ATOM   1674 C C   . TRP A 1 225 ? -27.062 -1.666  -12.302 1.00 15.58 ? 251 TRP A C   1 
ATOM   1675 O O   . TRP A 1 225 ? -27.065 -0.516  -11.830 1.00 15.66 ? 251 TRP A O   1 
ATOM   1676 C CB  . TRP A 1 225 ? -26.242 -2.598  -10.117 1.00 16.08 ? 251 TRP A CB  1 
ATOM   1677 C CG  . TRP A 1 225 ? -25.721 -3.798  -9.389  1.00 14.73 ? 251 TRP A CG  1 
ATOM   1678 C CD1 . TRP A 1 225 ? -26.460 -4.834  -8.887  1.00 14.35 ? 251 TRP A CD1 1 
ATOM   1679 C CD2 . TRP A 1 225 ? -24.356 -4.093  -9.081  1.00 11.22 ? 251 TRP A CD2 1 
ATOM   1680 N NE1 . TRP A 1 225 ? -25.640 -5.756  -8.296  1.00 19.18 ? 251 TRP A NE1 1 
ATOM   1681 C CE2 . TRP A 1 225 ? -24.343 -5.324  -8.390  1.00 15.78 ? 251 TRP A CE2 1 
ATOM   1682 C CE3 . TRP A 1 225 ? -23.143 -3.439  -9.321  1.00 12.74 ? 251 TRP A CE3 1 
ATOM   1683 C CZ2 . TRP A 1 225 ? -23.166 -5.909  -7.931  1.00 16.25 ? 251 TRP A CZ2 1 
ATOM   1684 C CZ3 . TRP A 1 225 ? -21.972 -4.024  -8.857  1.00 14.26 ? 251 TRP A CZ3 1 
ATOM   1685 C CH2 . TRP A 1 225 ? -21.996 -5.247  -8.174  1.00 15.02 ? 251 TRP A CH2 1 
ATOM   1686 N N   . PRO A 1 226 ? -27.738 -1.947  -13.411 1.00 13.96 ? 252 PRO A N   1 
ATOM   1687 C CA  . PRO A 1 226 ? -28.515 -0.902  -14.083 1.00 14.39 ? 252 PRO A CA  1 
ATOM   1688 C C   . PRO A 1 226 ? -29.699 -0.491  -13.228 1.00 17.76 ? 252 PRO A C   1 
ATOM   1689 O O   . PRO A 1 226 ? -30.126 -1.202  -12.316 1.00 22.82 ? 252 PRO A O   1 
ATOM   1690 C CB  . PRO A 1 226 ? -28.985 -1.575  -15.376 1.00 17.71 ? 252 PRO A CB  1 
ATOM   1691 C CG  . PRO A 1 226 ? -28.152 -2.823  -15.510 1.00 17.47 ? 252 PRO A CG  1 
ATOM   1692 C CD  . PRO A 1 226 ? -27.818 -3.237  -14.112 1.00 16.22 ? 252 PRO A CD  1 
ATOM   1693 N N   . GLN A 1 227 ? -30.234 0.683   -13.536 1.00 20.73 ? 254 GLN A N   1 
ATOM   1694 C CA  . GLN A 1 227 ? -31.380 1.184   -12.794 1.00 23.18 ? 254 GLN A CA  1 
ATOM   1695 C C   . GLN A 1 227 ? -32.597 0.306   -13.077 1.00 16.07 ? 254 GLN A C   1 
ATOM   1696 O O   . GLN A 1 227 ? -32.971 0.104   -14.235 1.00 18.91 ? 254 GLN A O   1 
ATOM   1697 C CB  . GLN A 1 227 ? -31.660 2.628   -13.199 1.00 21.99 ? 254 GLN A CB  1 
ATOM   1698 C CG  . GLN A 1 227 ? -32.205 3.481   -12.068 1.00 35.46 ? 254 GLN A CG  1 
ATOM   1699 C CD  . GLN A 1 227 ? -31.283 3.501   -10.856 1.00 38.41 ? 254 GLN A CD  1 
ATOM   1700 O OE1 . GLN A 1 227 ? -31.633 3.000   -9.788  1.00 32.52 ? 254 GLN A OE1 1 
ATOM   1701 N NE2 . GLN A 1 227 ? -30.101 4.094   -11.016 1.00 34.14 ? 254 GLN A NE2 1 
ATOM   1702 N N   . GLY A 1 228 ? -33.201 -0.231  -12.019 1.00 16.58 ? 255 GLY A N   1 
ATOM   1703 C CA  . GLY A 1 228 ? -34.464 -0.932  -12.166 1.00 14.90 ? 255 GLY A CA  1 
ATOM   1704 C C   . GLY A 1 228 ? -34.409 -2.330  -12.752 1.00 19.35 ? 255 GLY A C   1 
ATOM   1705 O O   . GLY A 1 228 ? -35.457 -2.871  -13.124 1.00 20.63 ? 255 GLY A O   1 
ATOM   1706 N N   . ARG A 1 229 ? -33.234 -2.947  -12.841 1.00 18.06 ? 256 ARG A N   1 
ATOM   1707 C CA  . ARG A 1 229 ? -33.151 -4.246  -13.499 1.00 20.88 ? 256 ARG A CA  1 
ATOM   1708 C C   . ARG A 1 229 ? -31.943 -5.022  -12.989 1.00 14.44 ? 256 ARG A C   1 
ATOM   1709 O O   . ARG A 1 229 ? -31.051 -4.477  -12.337 1.00 16.79 ? 256 ARG A O   1 
ATOM   1710 C CB  . ARG A 1 229 ? -33.156 -4.085  -15.023 1.00 29.63 ? 256 ARG A CB  1 
ATOM   1711 C CG  . ARG A 1 229 ? -32.080 -3.153  -15.520 1.00 22.39 ? 256 ARG A CG  1 
ATOM   1712 C CD  . ARG A 1 229 ? -31.790 -3.311  -17.000 1.00 30.75 ? 256 ARG A CD  1 
ATOM   1713 N NE  . ARG A 1 229 ? -31.889 -4.690  -17.457 1.00 35.92 ? 256 ARG A NE  1 
ATOM   1714 C CZ  . ARG A 1 229 ? -32.266 -5.043  -18.679 1.00 36.72 ? 256 ARG A CZ  1 
ATOM   1715 N NH1 . ARG A 1 229 ? -32.645 -4.140  -19.575 1.00 35.35 ? 256 ARG A NH1 1 
ATOM   1716 N NH2 . ARG A 1 229 ? -32.275 -6.332  -19.007 1.00 38.26 ? 256 ARG A NH2 1 
ATOM   1717 N N   . ALA A 1 230 ? -31.935 -6.314  -13.311 1.00 15.97 ? 257 ALA A N   1 
ATOM   1718 C CA  . ALA A 1 230 ? -30.948 -7.251  -12.809 1.00 12.13 ? 257 ALA A CA  1 
ATOM   1719 C C   . ALA A 1 230 ? -29.549 -6.911  -13.325 1.00 11.50 ? 257 ALA A C   1 
ATOM   1720 O O   . ALA A 1 230 ? -29.400 -6.252  -14.357 1.00 12.47 ? 257 ALA A O   1 
ATOM   1721 C CB  . ALA A 1 230 ? -31.334 -8.670  -13.232 1.00 13.47 ? 257 ALA A CB  1 
ATOM   1722 N N   . PRO A 1 231 ? -28.509 -7.347  -12.616 1.00 11.61 ? 258 PRO A N   1 
ATOM   1723 C CA  . PRO A 1 231 ? -27.143 -6.957  -12.990 1.00 11.51 ? 258 PRO A CA  1 
ATOM   1724 C C   . PRO A 1 231 ? -26.639 -7.599  -14.272 1.00 10.52 ? 258 PRO A C   1 
ATOM   1725 O O   . PRO A 1 231 ? -27.151 -8.611  -14.765 1.00 12.51 ? 258 PRO A O   1 
ATOM   1726 C CB  . PRO A 1 231 ? -26.285 -7.393  -11.795 1.00 14.37 ? 258 PRO A CB  1 
ATOM   1727 C CG  . PRO A 1 231 ? -27.138 -8.306  -10.995 1.00 19.24 ? 258 PRO A CG  1 
ATOM   1728 C CD  . PRO A 1 231 ? -28.564 -7.946  -11.272 1.00 10.47 ? 258 PRO A CD  1 
ATOM   1729 N N   . LEU A 1 232 ? -25.609 -6.954  -14.817 1.00 9.99  ? 259 LEU A N   1 
ATOM   1730 C CA  . LEU A 1 232 ? -24.876 -7.422  -15.982 1.00 11.23 ? 259 LEU A CA  1 
ATOM   1731 C C   . LEU A 1 232 ? -23.431 -7.654  -15.585 1.00 10.33 ? 259 LEU A C   1 
ATOM   1732 O O   . LEU A 1 232 ? -22.924 -7.046  -14.640 1.00 11.80 ? 259 LEU A O   1 
ATOM   1733 C CB  . LEU A 1 232 ? -24.861 -6.392  -17.118 1.00 11.28 ? 259 LEU A CB  1 
ATOM   1734 C CG  . LEU A 1 232 ? -26.108 -5.562  -17.428 1.00 13.89 ? 259 LEU A CG  1 
ATOM   1735 C CD1 . LEU A 1 232 ? -25.760 -4.413  -18.348 1.00 15.73 ? 259 LEU A CD1 1 
ATOM   1736 C CD2 . LEU A 1 232 ? -27.166 -6.433  -18.057 1.00 17.35 ? 259 LEU A CD2 1 
ATOM   1737 N N   . VAL A 1 233 ? -22.772 -8.552  -16.312 1.00 10.57 ? 260 VAL A N   1 
ATOM   1738 C CA  . VAL A 1 233 ? -21.337 -8.754  -16.198 1.00 9.58  ? 260 VAL A CA  1 
ATOM   1739 C C   . VAL A 1 233 ? -20.753 -8.501  -17.579 1.00 10.10 ? 260 VAL A C   1 
ATOM   1740 O O   . VAL A 1 233 ? -21.282 -9.003  -18.579 1.00 12.37 ? 260 VAL A O   1 
ATOM   1741 C CB  . VAL A 1 233 ? -21.021 -10.170 -15.690 1.00 13.14 ? 260 VAL A CB  1 
ATOM   1742 C CG1 . VAL A 1 233 ? -19.514 -10.396 -15.604 1.00 12.62 ? 260 VAL A CG1 1 
ATOM   1743 C CG2 . VAL A 1 233 ? -21.695 -10.405 -14.326 1.00 14.36 ? 260 VAL A CG2 1 
ATOM   1744 N N   . LEU A 1 234 ? -19.699 -7.688  -17.646 1.00 9.79  ? 261 LEU A N   1 
ATOM   1745 C CA  . LEU A 1 234 ? -19.161 -7.276  -18.937 1.00 10.70 ? 261 LEU A CA  1 
ATOM   1746 C C   . LEU A 1 234 ? -17.643 -7.304  -18.897 1.00 11.52 ? 261 LEU A C   1 
ATOM   1747 O O   . LEU A 1 234 ? -17.035 -6.692  -18.012 1.00 10.42 ? 261 LEU A O   1 
ATOM   1748 C CB  . LEU A 1 234 ? -19.649 -5.868  -19.306 1.00 11.28 ? 261 LEU A CB  1 
ATOM   1749 C CG  . LEU A 1 234 ? -19.179 -5.338  -20.654 1.00 9.11  ? 261 LEU A CG  1 
ATOM   1750 C CD1 . LEU A 1 234 ? -19.661 -6.240  -21.792 1.00 9.34  ? 261 LEU A CD1 1 
ATOM   1751 C CD2 . LEU A 1 234 ? -19.671 -3.909  -20.850 1.00 10.22 ? 261 LEU A CD2 1 
ATOM   1752 N N   . VAL A 1 235 ? -17.038 -8.016  -19.853 1.00 8.57  ? 262 VAL A N   1 
ATOM   1753 C CA  . VAL A 1 235 ? -15.595 -8.031  -20.071 1.00 8.23  ? 262 VAL A CA  1 
ATOM   1754 C C   . VAL A 1 235 ? -15.316 -7.375  -21.420 1.00 9.31  ? 262 VAL A C   1 
ATOM   1755 O O   . VAL A 1 235 ? -15.925 -7.745  -22.430 1.00 8.64  ? 262 VAL A O   1 
ATOM   1756 C CB  . VAL A 1 235 ? -15.055 -9.471  -20.068 1.00 11.36 ? 262 VAL A CB  1 
ATOM   1757 C CG1 . VAL A 1 235 ? -13.609 -9.506  -20.610 1.00 14.41 ? 262 VAL A CG1 1 
ATOM   1758 C CG2 . VAL A 1 235 ? -15.155 -10.097 -18.679 1.00 11.57 ? 262 VAL A CG2 1 
ATOM   1759 N N   . THR A 1 236 ? -14.418 -6.382  -21.437 1.00 8.69  ? 263 THR A N   1 
ATOM   1760 C CA  . THR A 1 236 ? -13.961 -5.729  -22.661 1.00 10.30 ? 263 THR A CA  1 
ATOM   1761 C C   . THR A 1 236 ? -12.438 -5.786  -22.663 1.00 9.25  ? 263 THR A C   1 
ATOM   1762 O O   . THR A 1 236 ? -11.782 -5.144  -21.832 1.00 9.77  ? 263 THR A O   1 
ATOM   1763 C CB  . THR A 1 236 ? -14.441 -4.279  -22.752 1.00 8.85  ? 263 THR A CB  1 
ATOM   1764 O OG1 . THR A 1 236 ? -14.013 -3.544  -21.599 1.00 10.52 ? 263 THR A OG1 1 
ATOM   1765 C CG2 . THR A 1 236 ? -15.963 -4.200  -22.882 1.00 9.53  ? 263 THR A CG2 1 
ATOM   1766 N N   . TYR A 1 237 ? -11.878 -6.581  -23.570 1.00 9.43  ? 264 TYR A N   1 
ATOM   1767 C CA  . TYR A 1 237 ? -10.439 -6.722  -23.723 1.00 9.30  ? 264 TYR A CA  1 
ATOM   1768 C C   . TYR A 1 237 ? -10.018 -6.152  -25.077 1.00 8.92  ? 264 TYR A C   1 
ATOM   1769 O O   . TYR A 1 237 ? -10.763 -6.254  -26.056 1.00 10.11 ? 264 TYR A O   1 
ATOM   1770 C CB  . TYR A 1 237 ? -10.081 -8.206  -23.629 1.00 12.88 ? 264 TYR A CB  1 
ATOM   1771 C CG  . TYR A 1 237 ? -10.001 -8.796  -22.224 1.00 10.10 ? 264 TYR A CG  1 
ATOM   1772 C CD1 . TYR A 1 237 ? -9.911  -7.990  -21.092 1.00 15.65 ? 264 TYR A CD1 1 
ATOM   1773 C CD2 . TYR A 1 237 ? -9.998  -10.179 -22.038 1.00 13.94 ? 264 TYR A CD2 1 
ATOM   1774 C CE1 . TYR A 1 237 ? -9.813  -8.538  -19.826 1.00 16.05 ? 264 TYR A CE1 1 
ATOM   1775 C CE2 . TYR A 1 237 ? -9.899  -10.736 -20.767 1.00 13.47 ? 264 TYR A CE2 1 
ATOM   1776 C CZ  . TYR A 1 237 ? -9.803  -9.904  -19.666 1.00 13.19 ? 264 TYR A CZ  1 
ATOM   1777 O OH  . TYR A 1 237 ? -9.699  -10.434 -18.390 1.00 12.72 ? 264 TYR A OH  1 
ATOM   1778 N N   . PHE A 1 238 ? -8.846  -5.517  -25.141 1.00 9.78  ? 265 PHE A N   1 
ATOM   1779 C CA  . PHE A 1 238 ? -8.443  -4.860  -26.385 1.00 9.62  ? 265 PHE A CA  1 
ATOM   1780 C C   . PHE A 1 238 ? -6.929  -4.862  -26.487 1.00 11.49 ? 265 PHE A C   1 
ATOM   1781 O O   . PHE A 1 238 ? -6.251  -4.485  -25.531 1.00 11.31 ? 265 PHE A O   1 
ATOM   1782 C CB  . PHE A 1 238 ? -8.965  -3.412  -26.443 1.00 11.20 ? 265 PHE A CB  1 
ATOM   1783 C CG  . PHE A 1 238 ? -8.625  -2.694  -27.721 1.00 9.11  ? 265 PHE A CG  1 
ATOM   1784 C CD1 . PHE A 1 238 ? -9.149  -3.128  -28.929 1.00 11.02 ? 265 PHE A CD1 1 
ATOM   1785 C CD2 . PHE A 1 238 ? -7.788  -1.579  -27.722 1.00 10.82 ? 265 PHE A CD2 1 
ATOM   1786 C CE1 . PHE A 1 238 ? -8.846  -2.481  -30.106 1.00 13.23 ? 265 PHE A CE1 1 
ATOM   1787 C CE2 . PHE A 1 238 ? -7.501  -0.926  -28.898 1.00 13.57 ? 265 PHE A CE2 1 
ATOM   1788 C CZ  . PHE A 1 238 ? -8.034  -1.385  -30.097 1.00 11.53 ? 265 PHE A CZ  1 
ATOM   1789 N N   . THR A 1 239 ? -6.398  -5.258  -27.646 1.00 9.39  ? 266 THR A N   1 
ATOM   1790 C CA  . THR A 1 239 ? -4.956  -5.209  -27.853 1.00 10.53 ? 266 THR A CA  1 
ATOM   1791 C C   . THR A 1 239 ? -4.668  -4.812  -29.301 1.00 10.46 ? 266 THR A C   1 
ATOM   1792 O O   . THR A 1 239 ? -5.543  -4.864  -30.167 1.00 12.84 ? 266 THR A O   1 
ATOM   1793 C CB  . THR A 1 239 ? -4.293  -6.519  -27.386 1.00 13.59 ? 266 THR A CB  1 
ATOM   1794 O OG1 . THR A 1 239 ? -2.877  -6.350  -27.264 1.00 12.81 ? 266 THR A OG1 1 
ATOM   1795 C CG2 . THR A 1 239 ? -4.613  -7.670  -28.343 1.00 12.92 ? 266 THR A CG2 1 
ATOM   1796 N N   . GLN A 1 240 ? -3.449  -4.363  -29.554 1.00 12.21 ? 267 GLN A N   1 
ATOM   1797 C CA  . GLN A 1 240 ? -3.113  -3.660  -30.783 1.00 14.51 ? 267 GLN A CA  1 
ATOM   1798 C C   . GLN A 1 240 ? -1.870  -4.236  -31.439 1.00 13.33 ? 267 GLN A C   1 
ATOM   1799 O O   . GLN A 1 240 ? -1.117  -4.990  -30.817 1.00 13.39 ? 267 GLN A O   1 
ATOM   1800 C CB  . GLN A 1 240 ? -2.927  -2.168  -30.464 1.00 14.20 ? 267 GLN A CB  1 
ATOM   1801 C CG  . GLN A 1 240 ? -4.165  -1.561  -29.846 1.00 13.28 ? 267 GLN A CG  1 
ATOM   1802 C CD  . GLN A 1 240 ? -4.051  -0.085  -29.639 1.00 12.31 ? 267 GLN A CD  1 
ATOM   1803 O OE1 . GLN A 1 240 ? -4.044  0.687   -30.591 1.00 15.09 ? 267 GLN A OE1 1 
ATOM   1804 N NE2 . GLN A 1 240 ? -3.997  0.327   -28.375 1.00 13.28 ? 267 GLN A NE2 1 
ATOM   1805 N N   . PRO A 1 241 ? -1.627  -3.904  -32.715 1.00 14.09 ? 268 PRO A N   1 
ATOM   1806 C CA  . PRO A 1 241 ? -0.506  -4.546  -33.432 1.00 15.85 ? 268 PRO A CA  1 
ATOM   1807 C C   . PRO A 1 241 ? 0.894   -4.076  -33.040 1.00 14.52 ? 268 PRO A C   1 
ATOM   1808 O O   . PRO A 1 241 ? 1.840   -4.866  -33.137 1.00 17.69 ? 268 PRO A O   1 
ATOM   1809 C CB  . PRO A 1 241 ? -0.802  -4.255  -34.912 1.00 18.59 ? 268 PRO A CB  1 
ATOM   1810 C CG  . PRO A 1 241 ? -2.198  -3.700  -34.968 1.00 18.97 ? 268 PRO A CG  1 
ATOM   1811 C CD  . PRO A 1 241 ? -2.546  -3.185  -33.621 1.00 17.34 ? 268 PRO A CD  1 
ATOM   1812 N N   A GLN A 1 242 ? 1.063   -2.836  -32.599 0.64 17.29 ? 269 GLN A N   1 
ATOM   1813 N N   B GLN A 1 242 ? 1.066   -2.821  -32.638 0.36 17.27 ? 269 GLN A N   1 
ATOM   1814 C CA  A GLN A 1 242 ? 2.388   -2.283  -32.348 0.64 14.90 ? 269 GLN A CA  1 
ATOM   1815 C CA  B GLN A 1 242 ? 2.391   -2.293  -32.341 0.36 14.96 ? 269 GLN A CA  1 
ATOM   1816 C C   A GLN A 1 242 ? 2.719   -2.398  -30.867 0.64 16.49 ? 269 GLN A C   1 
ATOM   1817 C C   B GLN A 1 242 ? 2.703   -2.443  -30.860 0.36 16.46 ? 269 GLN A C   1 
ATOM   1818 O O   A GLN A 1 242 ? 1.892   -2.054  -30.019 0.64 14.73 ? 269 GLN A O   1 
ATOM   1819 O O   B GLN A 1 242 ? 1.856   -2.166  -30.008 0.36 14.80 ? 269 GLN A O   1 
ATOM   1820 C CB  A GLN A 1 242 ? 2.454   -0.821  -32.794 0.64 14.48 ? 269 GLN A CB  1 
ATOM   1821 C CB  B GLN A 1 242 ? 2.488   -0.819  -32.736 0.36 14.54 ? 269 GLN A CB  1 
ATOM   1822 C CG  A GLN A 1 242 ? 1.868   -0.558  -34.184 0.64 19.01 ? 269 GLN A CG  1 
ATOM   1823 C CG  B GLN A 1 242 ? 2.041   -0.517  -34.156 0.36 18.78 ? 269 GLN A CG  1 
ATOM   1824 C CD  A GLN A 1 242 ? 0.343   -0.419  -34.192 0.64 20.48 ? 269 GLN A CD  1 
ATOM   1825 C CD  B GLN A 1 242 ? 2.691   -1.424  -35.177 0.36 19.51 ? 269 GLN A CD  1 
ATOM   1826 O OE1 A GLN A 1 242 ? -0.304  -0.354  -33.137 0.64 15.26 ? 269 GLN A OE1 1 
ATOM   1827 O OE1 B GLN A 1 242 ? 2.018   -2.012  -36.027 0.36 24.87 ? 269 GLN A OE1 1 
ATOM   1828 N NE2 A GLN A 1 242 ? -0.237  -0.380  -35.393 0.64 21.58 ? 269 GLN A NE2 1 
ATOM   1829 N NE2 B GLN A 1 242 ? 4.012   -1.546  -35.099 0.36 19.23 ? 269 GLN A NE2 1 
ATOM   1830 N N   . GLN A 1 243 ? 3.931   -2.877  -30.560 1.00 14.85 ? 270 GLN A N   1 
ATOM   1831 C CA  . GLN A 1 243 ? 4.329   -3.062  -29.166 1.00 13.18 ? 270 GLN A CA  1 
ATOM   1832 C C   . GLN A 1 243 ? 4.199   -1.781  -28.344 1.00 13.67 ? 270 GLN A C   1 
ATOM   1833 O O   . GLN A 1 243 ? 3.848   -1.845  -27.161 1.00 14.78 ? 270 GLN A O   1 
ATOM   1834 C CB  . GLN A 1 243 ? 5.768   -3.579  -29.093 1.00 16.42 ? 270 GLN A CB  1 
ATOM   1835 C CG  . GLN A 1 243 ? 6.303   -3.758  -27.664 1.00 19.45 ? 270 GLN A CG  1 
ATOM   1836 C CD  . GLN A 1 243 ? 7.491   -4.678  -27.598 1.00 23.27 ? 270 GLN A CD  1 
ATOM   1837 O OE1 . GLN A 1 243 ? 7.446   -5.743  -26.979 1.00 32.88 ? 270 GLN A OE1 1 
ATOM   1838 N NE2 . GLN A 1 243 ? 8.564   -4.286  -28.270 1.00 25.30 ? 270 GLN A NE2 1 
ATOM   1839 N N   . ASN A 1 244 ? 4.469   -0.616  -28.939 1.00 16.55 ? 271 ASN A N   1 
ATOM   1840 C CA  . ASN A 1 244 ? 4.439   0.651   -28.210 1.00 17.80 ? 271 ASN A CA  1 
ATOM   1841 C C   . ASN A 1 244 ? 3.122   1.412   -28.374 1.00 15.94 ? 271 ASN A C   1 
ATOM   1842 O O   . ASN A 1 244 ? 3.076   2.622   -28.102 1.00 18.57 ? 271 ASN A O   1 
ATOM   1843 C CB  . ASN A 1 244 ? 5.603   1.550   -28.633 1.00 19.14 ? 271 ASN A CB  1 
ATOM   1844 C CG  . ASN A 1 244 ? 5.655   1.765   -30.140 1.00 27.44 ? 271 ASN A CG  1 
ATOM   1845 O OD1 . ASN A 1 244 ? 4.933   1.114   -30.896 1.00 31.21 ? 271 ASN A OD1 1 
ATOM   1846 N ND2 . ASN A 1 244 ? 6.495   2.705   -30.581 1.00 31.60 ? 271 ASN A ND2 1 
ATOM   1847 N N   . ALA A 1 245 ? 2.051   0.740   -28.799 1.00 16.32 ? 272 ALA A N   1 
ATOM   1848 C CA  . ALA A 1 245 ? 0.797   1.430   -29.080 1.00 13.46 ? 272 ALA A CA  1 
ATOM   1849 C C   . ALA A 1 245 ? 0.253   2.149   -27.844 1.00 13.87 ? 272 ALA A C   1 
ATOM   1850 O O   . ALA A 1 245 ? 0.480   1.738   -26.706 1.00 14.75 ? 272 ALA A O   1 
ATOM   1851 C CB  . ALA A 1 245 ? -0.247  0.437   -29.598 1.00 12.99 ? 272 ALA A CB  1 
ATOM   1852 N N   A GLU A 1 246 ? -0.468  3.236   -28.094 0.55 15.99 ? 273 GLU A N   1 
ATOM   1853 N N   B GLU A 1 246 ? -0.472  3.238   -28.083 0.45 16.02 ? 273 GLU A N   1 
ATOM   1854 C CA  A GLU A 1 246 ? -1.108  4.009   -27.039 0.55 18.23 ? 273 GLU A CA  1 
ATOM   1855 C CA  B GLU A 1 246 ? -1.088  4.000   -27.005 0.45 18.23 ? 273 GLU A CA  1 
ATOM   1856 C C   A GLU A 1 246 ? -2.336  3.280   -26.509 0.55 16.54 ? 273 GLU A C   1 
ATOM   1857 C C   B GLU A 1 246 ? -2.318  3.271   -26.468 0.45 16.56 ? 273 GLU A C   1 
ATOM   1858 O O   A GLU A 1 246 ? -2.969  2.492   -27.212 0.55 17.13 ? 273 GLU A O   1 
ATOM   1859 O O   B GLU A 1 246 ? -2.930  2.448   -27.150 0.45 17.12 ? 273 GLU A O   1 
ATOM   1860 C CB  A GLU A 1 246 ? -1.570  5.348   -27.606 0.55 23.74 ? 273 GLU A CB  1 
ATOM   1861 C CB  B GLU A 1 246 ? -1.542  5.365   -27.521 0.45 23.72 ? 273 GLU A CB  1 
ATOM   1862 C CG  A GLU A 1 246 ? -1.775  5.324   -29.116 0.55 24.86 ? 273 GLU A CG  1 
ATOM   1863 C CG  B GLU A 1 246 ? -0.432  6.383   -27.731 0.45 21.12 ? 273 GLU A CG  1 
ATOM   1864 C CD  A GLU A 1 246 ? -3.086  5.949   -29.555 0.55 26.75 ? 273 GLU A CD  1 
ATOM   1865 C CD  B GLU A 1 246 ? -0.976  7.758   -28.077 0.45 36.01 ? 273 GLU A CD  1 
ATOM   1866 O OE1 A GLU A 1 246 ? -3.405  7.065   -29.092 0.55 24.93 ? 273 GLU A OE1 1 
ATOM   1867 O OE1 B GLU A 1 246 ? -2.113  7.833   -28.596 0.45 31.44 ? 273 GLU A OE1 1 
ATOM   1868 O OE2 A GLU A 1 246 ? -3.785  5.333   -30.385 0.55 28.75 ? 273 GLU A OE2 1 
ATOM   1869 O OE2 B GLU A 1 246 ? -0.275  8.763   -27.823 0.45 33.55 ? 273 GLU A OE2 1 
ATOM   1870 N N   A SER A 1 247 ? -2.689  3.571   -25.258 0.55 15.92 ? 274 SER A N   1 
ATOM   1871 N N   B SER A 1 247 ? -2.692  3.598   -25.231 0.45 15.87 ? 274 SER A N   1 
ATOM   1872 C CA  A SER A 1 247 ? -3.890  2.992   -24.675 0.55 13.05 ? 274 SER A CA  1 
ATOM   1873 C CA  B SER A 1 247 ? -3.900  3.021   -24.651 0.45 13.09 ? 274 SER A CA  1 
ATOM   1874 C C   A SER A 1 247 ? -5.138  3.582   -25.324 0.55 13.79 ? 274 SER A C   1 
ATOM   1875 C C   B SER A 1 247 ? -5.144  3.591   -25.323 0.45 13.81 ? 274 SER A C   1 
ATOM   1876 O O   A SER A 1 247 ? -5.149  4.729   -25.776 0.55 16.44 ? 274 SER A O   1 
ATOM   1877 O O   B SER A 1 247 ? -5.157  4.730   -25.795 0.45 16.43 ? 274 SER A O   1 
ATOM   1878 C CB  A SER A 1 247 ? -3.929  3.270   -23.175 0.55 16.60 ? 274 SER A CB  1 
ATOM   1879 C CB  B SER A 1 247 ? -3.966  3.302   -23.149 0.45 16.57 ? 274 SER A CB  1 
ATOM   1880 O OG  A SER A 1 247 ? -4.018  4.664   -22.949 0.55 21.27 ? 274 SER A OG  1 
ATOM   1881 O OG  B SER A 1 247 ? -2.919  2.650   -22.458 0.45 13.29 ? 274 SER A OG  1 
ATOM   1882 N N   . ARG A 1 248 ? -6.210  2.785   -25.353 1.00 11.56 ? 275 ARG A N   1 
ATOM   1883 C CA  . ARG A 1 248 ? -7.467  3.162   -26.006 1.00 12.60 ? 275 ARG A CA  1 
ATOM   1884 C C   . ARG A 1 248 ? -8.644  2.825   -25.086 1.00 12.28 ? 275 ARG A C   1 
ATOM   1885 O O   . ARG A 1 248 ? -9.469  1.970   -25.414 1.00 12.09 ? 275 ARG A O   1 
ATOM   1886 C CB  . ARG A 1 248 ? -7.626  2.459   -27.361 1.00 11.40 ? 275 ARG A CB  1 
ATOM   1887 C CG  . ARG A 1 248 ? -6.624  2.907   -28.400 1.00 14.52 ? 275 ARG A CG  1 
ATOM   1888 C CD  . ARG A 1 248 ? -6.844  4.358   -28.781 1.00 13.26 ? 275 ARG A CD  1 
ATOM   1889 N NE  . ARG A 1 248 ? -8.191  4.633   -29.255 1.00 14.94 ? 275 ARG A NE  1 
ATOM   1890 C CZ  . ARG A 1 248 ? -8.587  4.504   -30.516 1.00 12.48 ? 275 ARG A CZ  1 
ATOM   1891 N NH1 . ARG A 1 248 ? -7.776  4.026   -31.450 1.00 15.16 ? 275 ARG A NH1 1 
ATOM   1892 N NH2 . ARG A 1 248 ? -9.827  4.864   -30.849 1.00 14.30 ? 275 ARG A NH2 1 
ATOM   1893 N N   . ARG A 1 249 ? -8.737  3.520   -23.948 1.00 11.20 ? 276 ARG A N   1 
ATOM   1894 C CA  . ARG A 1 249 ? -9.873  3.298   -23.052 1.00 9.13  ? 276 ARG A CA  1 
ATOM   1895 C C   . ARG A 1 249 ? -11.195 3.695   -23.701 1.00 12.41 ? 276 ARG A C   1 
ATOM   1896 O O   . ARG A 1 249 ? -12.252 3.149   -23.340 1.00 12.58 ? 276 ARG A O   1 
ATOM   1897 C CB  . ARG A 1 249 ? -9.657  4.007   -21.712 1.00 12.00 ? 276 ARG A CB  1 
ATOM   1898 C CG  . ARG A 1 249 ? -8.547  3.376   -20.863 1.00 15.45 ? 276 ARG A CG  1 
ATOM   1899 C CD  . ARG A 1 249 ? -8.227  4.139   -19.589 1.00 20.15 ? 276 ARG A CD  1 
ATOM   1900 N NE  . ARG A 1 249 ? -6.904  3.762   -19.102 1.00 32.03 ? 276 ARG A NE  1 
ATOM   1901 C CZ  . ARG A 1 249 ? -5.772  4.361   -19.457 1.00 30.36 ? 276 ARG A CZ  1 
ATOM   1902 N NH1 . ARG A 1 249 ? -5.763  5.388   -20.289 1.00 25.00 ? 276 ARG A NH1 1 
ATOM   1903 N NH2 . ARG A 1 249 ? -4.617  3.907   -18.975 1.00 34.20 ? 276 ARG A NH2 1 
ATOM   1904 N N   . ASP A 1 250 ? -11.155 4.651   -24.642 1.00 12.59 ? 277 ASP A N   1 
ATOM   1905 C CA  . ASP A 1 250 ? -12.348 5.047   -25.394 1.00 12.18 ? 277 ASP A CA  1 
ATOM   1906 C C   . ASP A 1 250 ? -12.969 3.878   -26.146 1.00 9.96  ? 277 ASP A C   1 
ATOM   1907 O O   . ASP A 1 250 ? -14.187 3.856   -26.361 1.00 13.04 ? 277 ASP A O   1 
ATOM   1908 C CB  . ASP A 1 250 ? -11.995 6.162   -26.389 1.00 13.55 ? 277 ASP A CB  1 
ATOM   1909 C CG  . ASP A 1 250 ? -11.030 5.688   -27.478 1.00 16.01 ? 277 ASP A CG  1 
ATOM   1910 O OD1 . ASP A 1 250 ? -9.884  5.343   -27.143 1.00 16.59 ? 277 ASP A OD1 1 
ATOM   1911 O OD2 . ASP A 1 250 ? -11.418 5.666   -28.665 1.00 21.18 ? 277 ASP A OD2 1 
ATOM   1912 N N   . VAL A 1 251 ? -12.155 2.907   -26.562 1.00 9.91  ? 278 VAL A N   1 
ATOM   1913 C CA  . VAL A 1 251 ? -12.698 1.742   -27.251 1.00 14.10 ? 278 VAL A CA  1 
ATOM   1914 C C   . VAL A 1 251 ? -13.511 0.882   -26.292 1.00 9.82  ? 278 VAL A C   1 
ATOM   1915 O O   . VAL A 1 251 ? -14.590 0.386   -26.638 1.00 11.41 ? 278 VAL A O   1 
ATOM   1916 C CB  . VAL A 1 251 ? -11.576 0.964   -27.958 1.00 11.69 ? 278 VAL A CB  1 
ATOM   1917 C CG1 . VAL A 1 251 ? -12.071 -0.400  -28.454 1.00 13.54 ? 278 VAL A CG1 1 
ATOM   1918 C CG2 . VAL A 1 251 ? -11.033 1.776   -29.125 1.00 12.93 ? 278 VAL A CG2 1 
ATOM   1919 N N   . LEU A 1 252 ? -13.028 0.723   -25.058 1.00 10.63 ? 279 LEU A N   1 
ATOM   1920 C CA  . LEU A 1 252 ? -13.799 -0.010  -24.059 1.00 10.90 ? 279 LEU A CA  1 
ATOM   1921 C C   . LEU A 1 252 ? -15.120 0.684   -23.760 1.00 10.49 ? 279 LEU A C   1 
ATOM   1922 O O   . LEU A 1 252 ? -16.164 0.031   -23.640 1.00 12.74 ? 279 LEU A O   1 
ATOM   1923 C CB  . LEU A 1 252 ? -12.971 -0.174  -22.779 1.00 11.99 ? 279 LEU A CB  1 
ATOM   1924 C CG  . LEU A 1 252 ? -11.559 -0.742  -22.959 1.00 9.34  ? 279 LEU A CG  1 
ATOM   1925 C CD1 . LEU A 1 252 ? -10.949 -1.030  -21.616 1.00 9.57  ? 279 LEU A CD1 1 
ATOM   1926 C CD2 . LEU A 1 252 ? -11.545 -1.993  -23.859 1.00 11.32 ? 279 LEU A CD2 1 
ATOM   1927 N N   . ALA A 1 253 ? -15.081 2.006   -23.568 1.00 11.91 ? 280 ALA A N   1 
ATOM   1928 C CA  . ALA A 1 253 ? -16.308 2.749   -23.299 1.00 9.63  ? 280 ALA A CA  1 
ATOM   1929 C C   . ALA A 1 253 ? -17.282 2.643   -24.471 1.00 15.38 ? 280 ALA A C   1 
ATOM   1930 O O   . ALA A 1 253 ? -18.497 2.510   -24.268 1.00 11.99 ? 280 ALA A O   1 
ATOM   1931 C CB  . ALA A 1 253 ? -15.962 4.210   -23.023 1.00 11.26 ? 280 ALA A CB  1 
ATOM   1932 N N   . SER A 1 254 ? -16.762 2.691   -25.705 1.00 12.06 ? 281 SER A N   1 
ATOM   1933 C CA  . SER A 1 254 ? -17.620 2.558   -26.881 1.00 13.74 ? 281 SER A CA  1 
ATOM   1934 C C   . SER A 1 254 ? -18.262 1.181   -26.954 1.00 13.14 ? 281 SER A C   1 
ATOM   1935 O O   . SER A 1 254 ? -19.438 1.060   -27.321 1.00 12.42 ? 281 SER A O   1 
ATOM   1936 C CB  . SER A 1 254 ? -16.796 2.808   -28.138 1.00 12.11 ? 281 SER A CB  1 
ATOM   1937 O OG  . SER A 1 254 ? -16.440 4.171   -28.242 1.00 20.43 ? 281 SER A OG  1 
ATOM   1938 N N   . ALA A 1 255 ? -17.500 0.126   -26.645 1.00 11.01 ? 282 ALA A N   1 
ATOM   1939 C CA  . ALA A 1 255 ? -18.081 -1.214  -26.616 1.00 13.41 ? 282 ALA A CA  1 
ATOM   1940 C C   . ALA A 1 255 ? -19.194 -1.316  -25.586 1.00 10.09 ? 282 ALA A C   1 
ATOM   1941 O O   . ALA A 1 255 ? -20.258 -1.888  -25.869 1.00 14.10 ? 282 ALA A O   1 
ATOM   1942 C CB  . ALA A 1 255 ? -16.993 -2.250  -26.335 1.00 11.60 ? 282 ALA A CB  1 
ATOM   1943 N N   . ALA A 1 256 ? -18.975 -0.758  -24.388 1.00 13.73 ? 283 ALA A N   1 
ATOM   1944 C CA  . ALA A 1 256 ? -20.009 -0.773  -23.356 1.00 9.14  ? 283 ALA A CA  1 
ATOM   1945 C C   . ALA A 1 256 ? -21.231 0.019   -23.795 1.00 13.64 ? 283 ALA A C   1 
ATOM   1946 O O   . ALA A 1 256 ? -22.369 -0.370  -23.501 1.00 15.30 ? 283 ALA A O   1 
ATOM   1947 C CB  . ALA A 1 256 ? -19.449 -0.203  -22.056 1.00 11.60 ? 283 ALA A CB  1 
ATOM   1948 N N   . ARG A 1 257 ? -21.007 1.139   -24.498 1.00 12.59 ? 284 ARG A N   1 
ATOM   1949 C CA  . ARG A 1 257 ? -22.106 1.976   -24.966 1.00 14.04 ? 284 ARG A CA  1 
ATOM   1950 C C   . ARG A 1 257 ? -22.950 1.230   -25.992 1.00 16.05 ? 284 ARG A C   1 
ATOM   1951 O O   . ARG A 1 257 ? -24.183 1.297   -25.953 1.00 14.44 ? 284 ARG A O   1 
ATOM   1952 C CB  . ARG A 1 257 ? -21.540 3.269   -25.562 1.00 13.41 ? 284 ARG A CB  1 
ATOM   1953 C CG  . ARG A 1 257 ? -22.573 4.332   -25.933 1.00 16.68 ? 284 ARG A CG  1 
ATOM   1954 C CD  . ARG A 1 257 ? -21.898 5.662   -26.282 1.00 20.64 ? 284 ARG A CD  1 
ATOM   1955 N NE  . ARG A 1 257 ? -21.143 6.228   -25.165 1.00 22.85 ? 284 ARG A NE  1 
ATOM   1956 C CZ  . ARG A 1 257 ? -19.823 6.375   -25.132 1.00 24.26 ? 284 ARG A CZ  1 
ATOM   1957 N NH1 . ARG A 1 257 ? -19.060 6.049   -26.165 1.00 23.04 ? 284 ARG A NH1 1 
ATOM   1958 N NH2 . ARG A 1 257 ? -19.252 6.871   -24.036 1.00 28.84 ? 284 ARG A NH2 1 
ATOM   1959 N N   . ILE A 1 258 ? -22.297 0.498   -26.901 1.00 12.05 ? 285 ILE A N   1 
ATOM   1960 C CA  . ILE A 1 258 ? -23.023 -0.338  -27.851 1.00 12.04 ? 285 ILE A CA  1 
ATOM   1961 C C   . ILE A 1 258 ? -23.862 -1.374  -27.118 1.00 16.65 ? 285 ILE A C   1 
ATOM   1962 O O   . ILE A 1 258 ? -25.023 -1.624  -27.467 1.00 18.35 ? 285 ILE A O   1 
ATOM   1963 C CB  . ILE A 1 258 ? -22.024 -1.008  -28.813 1.00 12.17 ? 285 ILE A CB  1 
ATOM   1964 C CG1 . ILE A 1 258 ? -21.410 0.018   -29.764 1.00 13.05 ? 285 ILE A CG1 1 
ATOM   1965 C CG2 . ILE A 1 258 ? -22.684 -2.158  -29.570 1.00 13.43 ? 285 ILE A CG2 1 
ATOM   1966 C CD1 . ILE A 1 258 ? -20.171 -0.496  -30.464 1.00 14.94 ? 285 ILE A CD1 1 
ATOM   1967 N N   . ILE A 1 259 ? -23.276 -2.001  -26.102 1.00 18.77 ? 286 ILE A N   1 
ATOM   1968 C CA  . ILE A 1 259 ? -23.955 -3.049  -25.357 1.00 19.25 ? 286 ILE A CA  1 
ATOM   1969 C C   . ILE A 1 259 ? -25.146 -2.473  -24.605 1.00 22.63 ? 286 ILE A C   1 
ATOM   1970 O O   . ILE A 1 259 ? -26.214 -3.095  -24.532 1.00 23.61 ? 286 ILE A O   1 
ATOM   1971 C CB  . ILE A 1 259 ? -22.929 -3.732  -24.431 1.00 21.36 ? 286 ILE A CB  1 
ATOM   1972 C CG1 . ILE A 1 259 ? -22.164 -4.805  -25.208 1.00 27.05 ? 286 ILE A CG1 1 
ATOM   1973 C CG2 . ILE A 1 259 ? -23.591 -4.302  -23.177 1.00 31.00 ? 286 ILE A CG2 1 
ATOM   1974 C CD1 . ILE A 1 259 ? -22.883 -6.106  -25.303 1.00 28.01 ? 286 ILE A CD1 1 
ATOM   1975 N N   . ALA A 1 260 ? -24.992 -1.258  -24.065 1.00 19.76 ? 287 ALA A N   1 
ATOM   1976 C CA  . ALA A 1 260 ? -26.048 -0.649  -23.267 1.00 26.40 ? 287 ALA A CA  1 
ATOM   1977 C C   . ALA A 1 260 ? -27.223 -0.179  -24.117 1.00 21.21 ? 287 ALA A C   1 
ATOM   1978 O O   . ALA A 1 260 ? -28.351 -0.122  -23.616 1.00 28.06 ? 287 ALA A O   1 
ATOM   1979 C CB  . ALA A 1 260 ? -25.487 0.502   -22.428 1.00 21.43 ? 287 ALA A CB  1 
ATOM   1980 N N   . GLU A 1 261 ? -26.996 0.175   -25.389 1.00 20.64 ? 288 GLU A N   1 
ATOM   1981 C CA  . GLU A 1 261 ? -28.134 0.555   -26.227 1.00 24.02 ? 288 GLU A CA  1 
ATOM   1982 C C   . GLU A 1 261 ? -28.885 -0.667  -26.745 1.00 38.29 ? 288 GLU A C   1 
ATOM   1983 O O   . GLU A 1 261 ? -30.098 -0.594  -26.968 1.00 36.02 ? 288 GLU A O   1 
ATOM   1984 C CB  . GLU A 1 261 ? -27.728 1.490   -27.379 1.00 30.74 ? 288 GLU A CB  1 
ATOM   1985 C CG  . GLU A 1 261 ? -26.489 1.089   -28.176 1.00 33.73 ? 288 GLU A CG  1 
ATOM   1986 C CD  . GLU A 1 261 ? -26.554 1.520   -29.642 1.00 35.13 ? 288 GLU A CD  1 
ATOM   1987 O OE1 . GLU A 1 261 ? -27.512 1.132   -30.344 1.00 46.51 ? 288 GLU A OE1 1 
ATOM   1988 O OE2 . GLU A 1 261 ? -25.632 2.229   -30.102 1.00 39.05 ? 288 GLU A OE2 1 
ATOM   1989 N N   . GLY A 1 262 ? -28.192 -1.794  -26.919 1.00 44.17 ? 289 GLY A N   1 
ATOM   1990 C CA  . GLY A 1 262 ? -28.809 -3.025  -27.385 1.00 42.25 ? 289 GLY A CA  1 
ATOM   1991 C C   . GLY A 1 262 ? -29.663 -3.737  -26.355 1.00 48.98 ? 289 GLY A C   1 
ATOM   1992 O O   . GLY A 1 262 ? -30.353 -4.700  -26.713 1.00 47.83 ? 289 GLY A O   1 
ATOM   1993 N N   . LEU A 1 263 ? -29.622 -3.304  -25.097 1.00 44.67 ? 290 LEU A N   1 
ATOM   1994 C CA  . LEU A 1 263 ? -30.520 -3.830  -24.073 1.00 45.48 ? 290 LEU A CA  1 
ATOM   1995 C C   . LEU A 1 263 ? -31.778 -2.980  -24.058 1.00 50.17 ? 290 LEU A C   1 
ATOM   1996 O O   . LEU A 1 263 ? -32.526 -2.934  -25.035 1.00 50.68 ? 290 LEU A O   1 
ATOM   1997 C CB  . LEU A 1 263 ? -29.874 -3.789  -22.686 1.00 36.40 ? 290 LEU A CB  1 
ATOM   1998 C CG  . LEU A 1 263 ? -28.498 -4.427  -22.498 1.00 35.35 ? 290 LEU A CG  1 
ATOM   1999 C CD1 . LEU A 1 263 ? -27.767 -3.742  -21.362 1.00 32.62 ? 290 LEU A CD1 1 
ATOM   2000 C CD2 . LEU A 1 263 ? -28.615 -5.920  -22.237 1.00 40.36 ? 290 LEU A CD2 1 
ATOM   2001 O OXT . LEU A 1 263 ? -32.059 -2.308  -23.065 1.00 51.58 ? 290 LEU A OXT 1 
ATOM   2002 N N   . GLN B 1 1   ? 2.043   39.230  -22.048 1.00 43.97 ? 25  GLN B N   1 
ATOM   2003 C CA  . GLN B 1 1   ? 1.937   38.437  -20.830 1.00 18.13 ? 25  GLN B CA  1 
ATOM   2004 C C   . GLN B 1 1   ? 1.128   37.164  -21.081 1.00 24.23 ? 25  GLN B C   1 
ATOM   2005 O O   . GLN B 1 1   ? 0.335   36.748  -20.229 1.00 24.90 ? 25  GLN B O   1 
ATOM   2006 C CB  . GLN B 1 1   ? 1.301   39.267  -19.713 1.00 24.61 ? 25  GLN B CB  1 
ATOM   2007 C CG  . GLN B 1 1   ? 2.161   39.410  -18.469 1.00 31.69 ? 25  GLN B CG  1 
ATOM   2008 C CD  . GLN B 1 1   ? 1.752   40.598  -17.614 1.00 44.09 ? 25  GLN B CD  1 
ATOM   2009 O OE1 . GLN B 1 1   ? 0.621   41.078  -17.698 1.00 51.16 ? 25  GLN B OE1 1 
ATOM   2010 N NE2 . GLN B 1 1   ? 2.670   41.072  -16.777 1.00 50.30 ? 25  GLN B NE2 1 
ATOM   2011 N N   . THR B 1 2   ? 1.327   36.560  -22.258 1.00 16.69 ? 26  THR B N   1 
ATOM   2012 C CA  . THR B 1 2   ? 0.749   35.264  -22.606 1.00 16.25 ? 26  THR B CA  1 
ATOM   2013 C C   . THR B 1 2   ? 1.891   34.273  -22.792 1.00 17.82 ? 26  THR B C   1 
ATOM   2014 O O   . THR B 1 2   ? 2.746   34.459  -23.666 1.00 18.09 ? 26  THR B O   1 
ATOM   2015 C CB  . THR B 1 2   ? -0.082  35.347  -23.892 1.00 19.64 ? 26  THR B CB  1 
ATOM   2016 O OG1 . THR B 1 2   ? -1.077  36.375  -23.771 1.00 23.15 ? 26  THR B OG1 1 
ATOM   2017 C CG2 . THR B 1 2   ? -0.777  34.018  -24.163 1.00 15.81 ? 26  THR B CG2 1 
ATOM   2018 N N   . SER B 1 3   ? 1.912   33.230  -21.969 1.00 14.17 ? 27  SER B N   1 
ATOM   2019 C CA  . SER B 1 3   ? 2.947   32.218  -22.043 1.00 13.89 ? 27  SER B CA  1 
ATOM   2020 C C   . SER B 1 3   ? 2.602   31.163  -23.093 1.00 15.75 ? 27  SER B C   1 
ATOM   2021 O O   . SER B 1 3   ? 1.471   31.076  -23.586 1.00 17.63 ? 27  SER B O   1 
ATOM   2022 C CB  . SER B 1 3   ? 3.088   31.524  -20.694 1.00 18.73 ? 27  SER B CB  1 
ATOM   2023 O OG  . SER B 1 3   ? 1.931   30.735  -20.444 1.00 17.16 ? 27  SER B OG  1 
ATOM   2024 N N   . ALA B 1 4   ? 3.593   30.322  -23.408 1.00 17.31 ? 28  ALA B N   1 
ATOM   2025 C CA  . ALA B 1 4   ? 3.367   29.230  -24.351 1.00 15.10 ? 28  ALA B CA  1 
ATOM   2026 C C   . ALA B 1 4   ? 2.282   28.284  -23.850 1.00 12.79 ? 28  ALA B C   1 
ATOM   2027 O O   . ALA B 1 4   ? 1.429   27.831  -24.629 1.00 15.13 ? 28  ALA B O   1 
ATOM   2028 C CB  . ALA B 1 4   ? 4.670   28.464  -24.575 1.00 22.68 ? 28  ALA B CB  1 
ATOM   2029 N N   . VAL B 1 5   ? 2.301   27.976  -22.550 1.00 13.55 ? 29  VAL B N   1 
ATOM   2030 C CA  . VAL B 1 5   ? 1.261   27.130  -21.969 1.00 13.16 ? 29  VAL B CA  1 
ATOM   2031 C C   . VAL B 1 5   ? -0.104  27.794  -22.100 1.00 14.98 ? 29  VAL B C   1 
ATOM   2032 O O   . VAL B 1 5   ? -1.091  27.141  -22.462 1.00 12.48 ? 29  VAL B O   1 
ATOM   2033 C CB  . VAL B 1 5   ? 1.603   26.773  -20.509 1.00 15.30 ? 29  VAL B CB  1 
ATOM   2034 C CG1 . VAL B 1 5   ? 0.386   26.203  -19.802 1.00 14.55 ? 29  VAL B CG1 1 
ATOM   2035 C CG2 . VAL B 1 5   ? 2.761   25.779  -20.461 1.00 20.52 ? 29  VAL B CG2 1 
ATOM   2036 N N   . GLN B 1 6   ? -0.186  29.102  -21.817 1.00 13.51 ? 30  GLN B N   1 
ATOM   2037 C CA  . GLN B 1 6   ? -1.457  29.808  -21.959 1.00 9.95  ? 30  GLN B CA  1 
ATOM   2038 C C   . GLN B 1 6   ? -1.929  29.829  -23.407 1.00 13.99 ? 30  GLN B C   1 
ATOM   2039 O O   . GLN B 1 6   ? -3.135  29.749  -23.670 1.00 13.03 ? 30  GLN B O   1 
ATOM   2040 C CB  . GLN B 1 6   ? -1.351  31.229  -21.405 1.00 14.07 ? 30  GLN B CB  1 
ATOM   2041 C CG  . GLN B 1 6   ? -1.186  31.298  -19.891 1.00 13.41 ? 30  GLN B CG  1 
ATOM   2042 C CD  . GLN B 1 6   ? -0.878  32.685  -19.420 1.00 16.86 ? 30  GLN B CD  1 
ATOM   2043 O OE1 . GLN B 1 6   ? -0.040  33.376  -20.002 1.00 18.90 ? 30  GLN B OE1 1 
ATOM   2044 N NE2 . GLN B 1 6   ? -1.549  33.115  -18.352 1.00 19.35 ? 30  GLN B NE2 1 
ATOM   2045 N N   A GLN B 1 7   ? -1.000  29.938  -24.360 0.47 12.36 ? 31  GLN B N   1 
ATOM   2046 N N   B GLN B 1 7   ? -0.998  29.957  -24.356 0.53 12.36 ? 31  GLN B N   1 
ATOM   2047 C CA  A GLN B 1 7   ? -1.387  29.899  -25.766 0.47 14.53 ? 31  GLN B CA  1 
ATOM   2048 C CA  B GLN B 1 7   ? -1.363  29.887  -25.767 0.53 14.53 ? 31  GLN B CA  1 
ATOM   2049 C C   A GLN B 1 7   ? -1.955  28.536  -26.144 0.47 12.14 ? 31  GLN B C   1 
ATOM   2050 C C   B GLN B 1 7   ? -1.977  28.539  -26.107 0.53 12.13 ? 31  GLN B C   1 
ATOM   2051 O O   A GLN B 1 7   ? -2.919  28.449  -26.911 0.47 14.72 ? 31  GLN B O   1 
ATOM   2052 O O   B GLN B 1 7   ? -2.985  28.465  -26.817 0.53 14.68 ? 31  GLN B O   1 
ATOM   2053 C CB  A GLN B 1 7   ? -0.194  30.257  -26.656 0.47 16.86 ? 31  GLN B CB  1 
ATOM   2054 C CB  B GLN B 1 7   ? -0.127  30.124  -26.633 0.53 17.01 ? 31  GLN B CB  1 
ATOM   2055 C CG  A GLN B 1 7   ? 0.098   31.750  -26.778 0.47 17.05 ? 31  GLN B CG  1 
ATOM   2056 C CG  B GLN B 1 7   ? -0.421  30.674  -28.014 0.53 16.03 ? 31  GLN B CG  1 
ATOM   2057 C CD  A GLN B 1 7   ? 1.576   32.046  -27.003 0.47 22.39 ? 31  GLN B CD  1 
ATOM   2058 C CD  B GLN B 1 7   ? 0.832   31.205  -28.698 0.53 24.94 ? 31  GLN B CD  1 
ATOM   2059 O OE1 A GLN B 1 7   ? 2.269   31.302  -27.696 0.47 28.23 ? 31  GLN B OE1 1 
ATOM   2060 O OE1 B GLN B 1 7   ? 1.803   31.576  -28.035 0.53 32.70 ? 31  GLN B OE1 1 
ATOM   2061 N NE2 A GLN B 1 7   ? 2.058   33.148  -26.432 0.47 19.89 ? 31  GLN B NE2 1 
ATOM   2062 N NE2 B GLN B 1 7   ? 0.819   31.234  -30.026 0.53 26.74 ? 31  GLN B NE2 1 
ATOM   2063 N N   . LYS B 1 8   ? -1.380  27.459  -25.607 1.00 11.52 ? 32  LYS B N   1 
ATOM   2064 C CA  . LYS B 1 8   ? -1.897  26.131  -25.909 1.00 10.30 ? 32  LYS B CA  1 
ATOM   2065 C C   . LYS B 1 8   ? -3.278  25.925  -25.304 1.00 10.68 ? 32  LYS B C   1 
ATOM   2066 O O   . LYS B 1 8   ? -4.155  25.312  -25.926 1.00 12.63 ? 32  LYS B O   1 
ATOM   2067 C CB  . LYS B 1 8   ? -0.914  25.097  -25.383 1.00 13.32 ? 32  LYS B CB  1 
ATOM   2068 C CG  . LYS B 1 8   ? 0.297   24.916  -26.290 1.00 12.19 ? 32  LYS B CG  1 
ATOM   2069 C CD  . LYS B 1 8   ? 1.368   24.148  -25.572 1.00 15.71 ? 32  LYS B CD  1 
ATOM   2070 C CE  . LYS B 1 8   ? 2.513   23.777  -26.496 1.00 30.90 ? 32  LYS B CE  1 
ATOM   2071 N NZ  . LYS B 1 8   ? 3.467   24.898  -26.637 1.00 32.14 ? 32  LYS B NZ  1 
ATOM   2072 N N   . LEU B 1 9   ? -3.499  26.433  -24.093 1.00 12.71 ? 33  LEU B N   1 
ATOM   2073 C CA  . LEU B 1 9   ? -4.821  26.311  -23.488 1.00 12.31 ? 33  LEU B CA  1 
ATOM   2074 C C   . LEU B 1 9   ? -5.855  27.097  -24.276 1.00 10.78 ? 33  LEU B C   1 
ATOM   2075 O O   . LEU B 1 9   ? -7.003  26.663  -24.407 1.00 13.03 ? 33  LEU B O   1 
ATOM   2076 C CB  . LEU B 1 9   ? -4.786  26.775  -22.032 1.00 11.96 ? 33  LEU B CB  1 
ATOM   2077 C CG  . LEU B 1 9   ? -3.934  25.874  -21.130 1.00 10.97 ? 33  LEU B CG  1 
ATOM   2078 C CD1 . LEU B 1 9   ? -3.708  26.531  -19.776 1.00 10.15 ? 33  LEU B CD1 1 
ATOM   2079 C CD2 . LEU B 1 9   ? -4.577  24.490  -20.977 1.00 11.41 ? 33  LEU B CD2 1 
ATOM   2080 N N   . ALA B 1 10  ? -5.466  28.250  -24.814 1.00 11.15 ? 34  ALA B N   1 
ATOM   2081 C CA  . ALA B 1 10  ? -6.390  29.021  -25.636 1.00 11.70 ? 34  ALA B CA  1 
ATOM   2082 C C   . ALA B 1 10  ? -6.752  28.275  -26.914 1.00 10.82 ? 34  ALA B C   1 
ATOM   2083 O O   . ALA B 1 10  ? -7.908  28.315  -27.353 1.00 11.95 ? 34  ALA B O   1 
ATOM   2084 C CB  . ALA B 1 10  ? -5.770  30.377  -25.968 1.00 10.86 ? 34  ALA B CB  1 
ATOM   2085 N N   . ALA B 1 11  ? -5.779  27.584  -27.522 1.00 10.30 ? 35  ALA B N   1 
ATOM   2086 C CA  . ALA B 1 11  ? -6.073  26.805  -28.721 1.00 9.68  ? 35  ALA B CA  1 
ATOM   2087 C C   . ALA B 1 11  ? -6.987  25.633  -28.395 1.00 10.81 ? 35  ALA B C   1 
ATOM   2088 O O   . ALA B 1 11  ? -7.900  25.307  -29.164 1.00 12.88 ? 35  ALA B O   1 
ATOM   2089 C CB  . ALA B 1 11  ? -4.770  26.307  -29.352 1.00 10.97 ? 35  ALA B CB  1 
ATOM   2090 N N   . LEU B 1 12  ? -6.750  24.984  -27.257 1.00 11.03 ? 36  LEU B N   1 
ATOM   2091 C CA  . LEU B 1 12  ? -7.628  23.913  -26.823 1.00 10.84 ? 36  LEU B CA  1 
ATOM   2092 C C   . LEU B 1 12  ? -9.038  24.442  -26.640 1.00 9.35  ? 36  LEU B C   1 
ATOM   2093 O O   . LEU B 1 12  ? -10.000 23.860  -27.152 1.00 9.54  ? 36  LEU B O   1 
ATOM   2094 C CB  . LEU B 1 12  ? -7.089  23.308  -25.527 1.00 10.42 ? 36  LEU B CB  1 
ATOM   2095 C CG  . LEU B 1 12  ? -8.022  22.391  -24.748 1.00 9.27  ? 36  LEU B CG  1 
ATOM   2096 C CD1 . LEU B 1 12  ? -8.372  21.136  -25.543 1.00 12.31 ? 36  LEU B CD1 1 
ATOM   2097 C CD2 . LEU B 1 12  ? -7.440  22.047  -23.367 1.00 10.79 ? 36  LEU B CD2 1 
ATOM   2098 N N   . GLU B 1 13  ? -9.175  25.572  -25.939 1.00 13.50 ? 37  GLU B N   1 
ATOM   2099 C CA  . GLU B 1 13  ? -10.493 26.144  -25.711 1.00 9.11  ? 37  GLU B CA  1 
ATOM   2100 C C   . GLU B 1 13  ? -11.177 26.480  -27.030 1.00 12.40 ? 37  GLU B C   1 
ATOM   2101 O O   . GLU B 1 13  ? -12.378 26.229  -27.200 1.00 12.53 ? 37  GLU B O   1 
ATOM   2102 C CB  . GLU B 1 13  ? -10.377 27.376  -24.814 1.00 11.33 ? 37  GLU B CB  1 
ATOM   2103 C CG  . GLU B 1 13  ? -11.698 28.093  -24.611 1.00 10.79 ? 37  GLU B CG  1 
ATOM   2104 C CD  . GLU B 1 13  ? -11.522 29.387  -23.858 1.00 10.95 ? 37  GLU B CD  1 
ATOM   2105 O OE1 . GLU B 1 13  ? -10.836 30.285  -24.377 1.00 10.86 ? 37  GLU B OE1 1 
ATOM   2106 O OE2 . GLU B 1 13  ? -12.045 29.484  -22.734 1.00 11.33 ? 37  GLU B OE2 1 
ATOM   2107 N N   . LYS B 1 14  ? -10.426 27.030  -27.988 1.00 11.41 ? 38  LYS B N   1 
ATOM   2108 C CA  . LYS B 1 14  ? -11.041 27.420  -29.251 1.00 12.84 ? 38  LYS B CA  1 
ATOM   2109 C C   . LYS B 1 14  ? -11.633 26.217  -29.980 1.00 13.59 ? 38  LYS B C   1 
ATOM   2110 O O   . LYS B 1 14  ? -12.727 26.308  -30.548 1.00 15.73 ? 38  LYS B O   1 
ATOM   2111 C CB  . LYS B 1 14  ? -10.045 28.181  -30.132 1.00 16.22 ? 38  LYS B CB  1 
ATOM   2112 C CG  . LYS B 1 14  ? -10.629 28.557  -31.493 1.00 21.79 ? 38  LYS B CG  1 
ATOM   2113 C CD  . LYS B 1 14  ? -9.628  29.304  -32.359 1.00 24.33 ? 38  LYS B CD  1 
ATOM   2114 C CE  . LYS B 1 14  ? -10.058 29.307  -33.826 1.00 29.72 ? 38  LYS B CE  1 
ATOM   2115 N NZ  . LYS B 1 14  ? -11.128 28.297  -34.105 1.00 35.59 ? 38  LYS B NZ  1 
ATOM   2116 N N   . SER B 1 15  ? -10.940 25.074  -29.955 1.00 12.85 ? 39  SER B N   1 
ATOM   2117 C CA  . SER B 1 15  ? -11.449 23.869  -30.600 1.00 11.57 ? 39  SER B CA  1 
ATOM   2118 C C   . SER B 1 15  ? -12.524 23.161  -29.788 1.00 13.88 ? 39  SER B C   1 
ATOM   2119 O O   . SER B 1 15  ? -13.097 22.180  -30.269 1.00 23.98 ? 39  SER B O   1 
ATOM   2120 C CB  . SER B 1 15  ? -10.310 22.875  -30.858 1.00 16.62 ? 39  SER B CB  1 
ATOM   2121 O OG  . SER B 1 15  ? -9.145  23.520  -31.328 1.00 17.40 ? 39  SER B OG  1 
ATOM   2122 N N   . SER B 1 16  ? -12.809 23.619  -28.571 1.00 12.80 ? 40  SER B N   1 
ATOM   2123 C CA  . SER B 1 16  ? -13.752 22.945  -27.692 1.00 12.23 ? 40  SER B CA  1 
ATOM   2124 C C   . SER B 1 16  ? -15.159 23.513  -27.795 1.00 15.22 ? 40  SER B C   1 
ATOM   2125 O O   . SER B 1 16  ? -16.116 22.823  -27.430 1.00 24.05 ? 40  SER B O   1 
ATOM   2126 C CB  . SER B 1 16  ? -13.277 23.069  -26.239 1.00 12.04 ? 40  SER B CB  1 
ATOM   2127 O OG  . SER B 1 16  ? -13.670 24.326  -25.675 1.00 12.77 ? 40  SER B OG  1 
ATOM   2128 N N   . GLY B 1 17  ? -15.292 24.753  -28.260 1.00 18.61 ? 41  GLY B N   1 
ATOM   2129 C CA  . GLY B 1 17  ? -16.562 25.445  -28.289 1.00 22.09 ? 41  GLY B CA  1 
ATOM   2130 C C   . GLY B 1 17  ? -16.996 26.054  -26.973 1.00 23.80 ? 41  GLY B C   1 
ATOM   2131 O O   . GLY B 1 17  ? -17.911 26.892  -26.968 1.00 25.02 ? 41  GLY B O   1 
ATOM   2132 N N   . GLY B 1 18  ? -16.362 25.685  -25.858 1.00 16.57 ? 42  GLY B N   1 
ATOM   2133 C CA  . GLY B 1 18  ? -16.771 26.123  -24.547 1.00 12.15 ? 42  GLY B CA  1 
ATOM   2134 C C   . GLY B 1 18  ? -15.837 27.156  -23.950 1.00 10.46 ? 42  GLY B C   1 
ATOM   2135 O O   . GLY B 1 18  ? -15.048 27.806  -24.649 1.00 16.28 ? 42  GLY B O   1 
ATOM   2136 N N   . ARG B 1 19  ? -15.945 27.324  -22.635 1.00 9.29  ? 43  ARG B N   1 
ATOM   2137 C CA  . ARG B 1 19  ? -15.126 28.253  -21.869 1.00 9.91  ? 43  ARG B CA  1 
ATOM   2138 C C   . ARG B 1 19  ? -14.365 27.442  -20.834 1.00 10.68 ? 43  ARG B C   1 
ATOM   2139 O O   . ARG B 1 19  ? -14.976 26.719  -20.036 1.00 9.46  ? 43  ARG B O   1 
ATOM   2140 C CB  . ARG B 1 19  ? -15.992 29.326  -21.195 1.00 10.49 ? 43  ARG B CB  1 
ATOM   2141 C CG  . ARG B 1 19  ? -15.186 30.375  -20.439 1.00 8.51  ? 43  ARG B CG  1 
ATOM   2142 C CD  . ARG B 1 19  ? -16.010 31.584  -19.966 1.00 10.16 ? 43  ARG B CD  1 
ATOM   2143 N NE  . ARG B 1 19  ? -17.127 31.210  -19.102 1.00 11.12 ? 43  ARG B NE  1 
ATOM   2144 C CZ  . ARG B 1 19  ? -17.128 31.362  -17.784 1.00 10.11 ? 43  ARG B CZ  1 
ATOM   2145 N NH1 . ARG B 1 19  ? -16.108 31.928  -17.148 1.00 10.60 ? 43  ARG B NH1 1 
ATOM   2146 N NH2 . ARG B 1 19  ? -18.174 30.933  -17.085 1.00 12.77 ? 43  ARG B NH2 1 
ATOM   2147 N N   . LEU B 1 20  ? -13.042 27.566  -20.855 1.00 9.45  ? 44  LEU B N   1 
ATOM   2148 C CA  . LEU B 1 20  ? -12.131 26.764  -20.044 1.00 7.60  ? 44  LEU B CA  1 
ATOM   2149 C C   . LEU B 1 20  ? -11.442 27.650  -19.014 1.00 10.71 ? 44  LEU B C   1 
ATOM   2150 O O   . LEU B 1 20  ? -10.953 28.735  -19.351 1.00 11.74 ? 44  LEU B O   1 
ATOM   2151 C CB  . LEU B 1 20  ? -11.066 26.153  -20.953 1.00 9.23  ? 44  LEU B CB  1 
ATOM   2152 C CG  . LEU B 1 20  ? -9.933  25.357  -20.303 1.00 9.59  ? 44  LEU B CG  1 
ATOM   2153 C CD1 . LEU B 1 20  ? -10.466 24.104  -19.590 1.00 11.05 ? 44  LEU B CD1 1 
ATOM   2154 C CD2 . LEU B 1 20  ? -8.902  24.972  -21.367 1.00 11.01 ? 44  LEU B CD2 1 
ATOM   2155 N N   . GLY B 1 21  ? -11.384 27.175  -17.766 1.00 10.85 ? 45  GLY B N   1 
ATOM   2156 C CA  . GLY B 1 21  ? -10.666 27.886  -16.721 1.00 10.36 ? 45  GLY B CA  1 
ATOM   2157 C C   . GLY B 1 21  ? -9.681  26.973  -16.031 1.00 9.45  ? 45  GLY B C   1 
ATOM   2158 O O   . GLY B 1 21  ? -10.051 25.857  -15.678 1.00 10.28 ? 45  GLY B O   1 
ATOM   2159 N N   . VAL B 1 22  ? -8.435  27.412  -15.849 1.00 8.96  ? 46  VAL B N   1 
ATOM   2160 C CA  . VAL B 1 22  ? -7.357  26.580  -15.315 1.00 8.26  ? 46  VAL B CA  1 
ATOM   2161 C C   . VAL B 1 22  ? -6.581  27.381  -14.278 1.00 9.67  ? 46  VAL B C   1 
ATOM   2162 O O   . VAL B 1 22  ? -6.289  28.567  -14.479 1.00 9.46  ? 46  VAL B O   1 
ATOM   2163 C CB  . VAL B 1 22  ? -6.403  26.084  -16.426 1.00 11.15 ? 46  VAL B CB  1 
ATOM   2164 C CG1 . VAL B 1 22  ? -5.229  25.253  -15.841 1.00 9.23  ? 46  VAL B CG1 1 
ATOM   2165 C CG2 . VAL B 1 22  ? -7.167  25.298  -17.520 1.00 9.86  ? 46  VAL B CG2 1 
ATOM   2166 N N   . ALA B 1 23  ? -6.229  26.729  -13.174 1.00 8.48  ? 47  ALA B N   1 
ATOM   2167 C CA  . ALA B 1 23  ? -5.304  27.282  -12.185 1.00 7.69  ? 47  ALA B CA  1 
ATOM   2168 C C   . ALA B 1 23  ? -4.411  26.169  -11.668 1.00 8.44  ? 47  ALA B C   1 
ATOM   2169 O O   . ALA B 1 23  ? -4.901  25.165  -11.131 1.00 10.50 ? 47  ALA B O   1 
ATOM   2170 C CB  . ALA B 1 23  ? -6.032  27.969  -11.026 1.00 8.82  ? 47  ALA B CB  1 
ATOM   2171 N N   . LEU B 1 24  ? -3.106  26.344  -11.847 1.00 9.59  ? 48  LEU B N   1 
ATOM   2172 C CA  . LEU B 1 24  ? -2.094  25.461  -11.289 1.00 8.96  ? 48  LEU B CA  1 
ATOM   2173 C C   . LEU B 1 24  ? -1.294  26.202  -10.231 1.00 10.85 ? 48  LEU B C   1 
ATOM   2174 O O   . LEU B 1 24  ? -0.961  27.378  -10.407 1.00 12.01 ? 48  LEU B O   1 
ATOM   2175 C CB  . LEU B 1 24  ? -1.121  25.014  -12.393 1.00 13.13 ? 48  LEU B CB  1 
ATOM   2176 C CG  . LEU B 1 24  ? 0.199   24.375  -11.930 1.00 11.52 ? 48  LEU B CG  1 
ATOM   2177 C CD1 . LEU B 1 24  ? -0.027  22.959  -11.429 1.00 13.93 ? 48  LEU B CD1 1 
ATOM   2178 C CD2 . LEU B 1 24  ? 1.265   24.415  -13.036 1.00 15.26 ? 48  LEU B CD2 1 
ATOM   2179 N N   . ILE B 1 25  ? -1.004  25.523  -9.124  1.00 10.21 ? 49  ILE B N   1 
ATOM   2180 C CA  . ILE B 1 25  ? 0.039   25.936  -8.187  1.00 11.80 ? 49  ILE B CA  1 
ATOM   2181 C C   . ILE B 1 25  ? 1.062   24.818  -8.130  1.00 10.59 ? 49  ILE B C   1 
ATOM   2182 O O   . ILE B 1 25  ? 0.707   23.665  -7.850  1.00 11.62 ? 49  ILE B O   1 
ATOM   2183 C CB  . ILE B 1 25  ? -0.511  26.212  -6.782  1.00 11.03 ? 49  ILE B CB  1 
ATOM   2184 C CG1 . ILE B 1 25  ? -1.627  27.258  -6.830  1.00 12.52 ? 49  ILE B CG1 1 
ATOM   2185 C CG2 . ILE B 1 25  ? 0.619   26.616  -5.841  1.00 11.83 ? 49  ILE B CG2 1 
ATOM   2186 C CD1 . ILE B 1 25  ? -2.364  27.403  -5.525  1.00 13.97 ? 49  ILE B CD1 1 
ATOM   2187 N N   . ASP B 1 26  ? 2.329   25.152  -8.383  1.00 10.69 ? 50  ASP B N   1 
ATOM   2188 C CA  . ASP B 1 26  ? 3.444   24.211  -8.270  1.00 11.15 ? 50  ASP B CA  1 
ATOM   2189 C C   . ASP B 1 26  ? 4.099   24.489  -6.930  1.00 15.46 ? 50  ASP B C   1 
ATOM   2190 O O   . ASP B 1 26  ? 4.734   25.534  -6.756  1.00 14.61 ? 50  ASP B O   1 
ATOM   2191 C CB  . ASP B 1 26  ? 4.436   24.436  -9.411  1.00 13.83 ? 50  ASP B CB  1 
ATOM   2192 C CG  . ASP B 1 26  ? 5.575   23.419  -9.428  1.00 19.00 ? 50  ASP B CG  1 
ATOM   2193 O OD1 . ASP B 1 26  ? 5.759   22.675  -8.435  1.00 20.63 ? 50  ASP B OD1 1 
ATOM   2194 O OD2 . ASP B 1 26  ? 6.295   23.368  -10.459 1.00 23.10 ? 50  ASP B OD2 1 
ATOM   2195 N N   . THR B 1 27  ? 3.928   23.573  -5.971  1.00 12.41 ? 51  THR B N   1 
ATOM   2196 C CA  . THR B 1 27  ? 4.508   23.815  -4.647  1.00 12.63 ? 51  THR B CA  1 
ATOM   2197 C C   . THR B 1 27  ? 6.019   23.630  -4.605  1.00 16.35 ? 51  THR B C   1 
ATOM   2198 O O   . THR B 1 27  ? 6.599   23.835  -3.538  1.00 23.33 ? 51  THR B O   1 
ATOM   2199 C CB  . THR B 1 27  ? 3.831   23.007  -3.535  1.00 13.37 ? 51  THR B CB  1 
ATOM   2200 O OG1 . THR B 1 27  ? 4.209   21.618  -3.626  1.00 15.26 ? 51  THR B OG1 1 
ATOM   2201 C CG2 . THR B 1 27  ? 2.310   23.134  -3.606  1.00 16.77 ? 51  THR B CG2 1 
ATOM   2202 N N   . ALA B 1 28  ? 6.666   23.277  -5.724  1.00 16.81 ? 52  ALA B N   1 
ATOM   2203 C CA  . ALA B 1 28  ? 8.129   23.233  -5.753  1.00 17.06 ? 52  ALA B CA  1 
ATOM   2204 C C   . ALA B 1 28  ? 8.729   24.629  -5.713  1.00 21.42 ? 52  ALA B C   1 
ATOM   2205 O O   . ALA B 1 28  ? 9.851   24.806  -5.220  1.00 19.88 ? 52  ALA B O   1 
ATOM   2206 C CB  . ALA B 1 28  ? 8.620   22.494  -6.995  1.00 20.51 ? 52  ALA B CB  1 
ATOM   2207 N N   . ASP B 1 29  ? 8.009   25.627  -6.243  1.00 16.97 ? 53  ASP B N   1 
ATOM   2208 C CA  . ASP B 1 29  ? 8.450   27.014  -6.207  1.00 16.78 ? 53  ASP B CA  1 
ATOM   2209 C C   . ASP B 1 29  ? 7.320   27.998  -5.935  1.00 15.06 ? 53  ASP B C   1 
ATOM   2210 O O   . ASP B 1 29  ? 7.563   29.212  -5.963  1.00 13.91 ? 53  ASP B O   1 
ATOM   2211 C CB  . ASP B 1 29  ? 9.151   27.385  -7.524  1.00 17.11 ? 53  ASP B CB  1 
ATOM   2212 C CG  . ASP B 1 29  ? 8.305   27.075  -8.737  1.00 19.27 ? 53  ASP B CG  1 
ATOM   2213 O OD1 . ASP B 1 29  ? 7.100   26.764  -8.558  1.00 18.15 ? 53  ASP B OD1 1 
ATOM   2214 O OD2 . ASP B 1 29  ? 8.850   27.150  -9.867  1.00 20.44 ? 53  ASP B OD2 1 
ATOM   2215 N N   . ASN B 1 30  ? 6.094   27.521  -5.710  1.00 12.36 ? 54  ASN B N   1 
ATOM   2216 C CA  . ASN B 1 30  ? 4.907   28.333  -5.449  1.00 14.21 ? 54  ASN B CA  1 
ATOM   2217 C C   . ASN B 1 30  ? 4.412   29.109  -6.662  1.00 11.78 ? 54  ASN B C   1 
ATOM   2218 O O   . ASN B 1 30  ? 3.518   29.967  -6.520  1.00 14.10 ? 54  ASN B O   1 
ATOM   2219 C CB  . ASN B 1 30  ? 5.068   29.254  -4.237  1.00 13.98 ? 54  ASN B CB  1 
ATOM   2220 C CG  . ASN B 1 30  ? 5.531   28.514  -3.026  1.00 19.09 ? 54  ASN B CG  1 
ATOM   2221 O OD1 . ASN B 1 30  ? 5.050   27.421  -2.741  1.00 20.62 ? 54  ASN B OD1 1 
ATOM   2222 N ND2 . ASN B 1 30  ? 6.495   29.087  -2.308  1.00 22.28 ? 54  ASN B ND2 1 
ATOM   2223 N N   . THR B 1 31  ? 4.933   28.826  -7.852  1.00 12.47 ? 55  THR B N   1 
ATOM   2224 C CA  . THR B 1 31  ? 4.508   29.571  -9.018  1.00 12.17 ? 55  THR B CA  1 
ATOM   2225 C C   . THR B 1 31  ? 3.136   29.105  -9.478  1.00 13.57 ? 55  THR B C   1 
ATOM   2226 O O   . THR B 1 31  ? 2.646   28.027  -9.117  1.00 14.54 ? 55  THR B O   1 
ATOM   2227 C CB  . THR B 1 31  ? 5.497   29.423  -10.171 1.00 14.49 ? 55  THR B CB  1 
ATOM   2228 O OG1 . THR B 1 31  ? 5.649   28.039  -10.497 1.00 17.51 ? 55  THR B OG1 1 
ATOM   2229 C CG2 . THR B 1 31  ? 6.847   30.014  -9.780  1.00 16.42 ? 55  THR B CG2 1 
ATOM   2230 N N   . GLN B 1 32  ? 2.529   29.931  -10.305 1.00 17.76 ? 56  GLN B N   1 
ATOM   2231 C CA  . GLN B 1 32  ? 1.152   29.744  -10.702 1.00 15.08 ? 56  GLN B CA  1 
ATOM   2232 C C   . GLN B 1 32  ? 1.060   29.854  -12.213 1.00 17.71 ? 56  GLN B C   1 
ATOM   2233 O O   . GLN B 1 32  ? 1.808   30.605  -12.845 1.00 22.86 ? 56  GLN B O   1 
ATOM   2234 C CB  . GLN B 1 32  ? 0.298   30.804  -10.027 1.00 16.47 ? 56  GLN B CB  1 
ATOM   2235 C CG  . GLN B 1 32  ? 0.031   30.464  -8.577  1.00 23.76 ? 56  GLN B CG  1 
ATOM   2236 C CD  . GLN B 1 32  ? -0.803  31.493  -7.871  1.00 28.87 ? 56  GLN B CD  1 
ATOM   2237 O OE1 . GLN B 1 32  ? -1.825  31.941  -8.384  1.00 22.38 ? 56  GLN B OE1 1 
ATOM   2238 N NE2 . GLN B 1 32  ? -0.371  31.876  -6.674  1.00 30.25 ? 56  GLN B NE2 1 
ATOM   2239 N N   . VAL B 1 33  ? 0.164   29.059  -12.785 1.00 12.77 ? 57  VAL B N   1 
ATOM   2240 C CA  . VAL B 1 33  ? -0.232  29.168  -14.181 1.00 13.70 ? 57  VAL B CA  1 
ATOM   2241 C C   . VAL B 1 33  ? -1.745  29.263  -14.194 1.00 12.70 ? 57  VAL B C   1 
ATOM   2242 O O   . VAL B 1 33  ? -2.424  28.418  -13.600 1.00 13.52 ? 57  VAL B O   1 
ATOM   2243 C CB  . VAL B 1 33  ? 0.228   27.950  -15.001 1.00 21.58 ? 57  VAL B CB  1 
ATOM   2244 C CG1 . VAL B 1 33  ? -0.310  28.039  -16.429 1.00 21.58 ? 57  VAL B CG1 1 
ATOM   2245 C CG2 . VAL B 1 33  ? 1.740   27.845  -14.977 1.00 20.14 ? 57  VAL B CG2 1 
ATOM   2246 N N   . LEU B 1 34  ? -2.271  30.282  -14.867 1.00 13.37 ? 59  LEU B N   1 
ATOM   2247 C CA  . LEU B 1 34  ? -3.685  30.615  -14.837 1.00 12.93 ? 59  LEU B CA  1 
ATOM   2248 C C   . LEU B 1 34  ? -4.173  30.795  -16.267 1.00 15.74 ? 59  LEU B C   1 
ATOM   2249 O O   . LEU B 1 34  ? -3.485  31.392  -17.100 1.00 14.41 ? 59  LEU B O   1 
ATOM   2250 C CB  . LEU B 1 34  ? -3.877  31.932  -14.085 1.00 17.24 ? 59  LEU B CB  1 
ATOM   2251 C CG  . LEU B 1 34  ? -3.471  31.990  -12.610 1.00 18.01 ? 59  LEU B CG  1 
ATOM   2252 C CD1 . LEU B 1 34  ? -3.570  33.417  -12.190 1.00 25.05 ? 59  LEU B CD1 1 
ATOM   2253 C CD2 . LEU B 1 34  ? -4.385  31.141  -11.759 1.00 17.08 ? 59  LEU B CD2 1 
ATOM   2254 N N   . TYR B 1 35  ? -5.366  30.278  -16.547 1.00 11.06 ? 60  TYR B N   1 
ATOM   2255 C CA  . TYR B 1 35  ? -6.087  30.588  -17.773 1.00 10.27 ? 60  TYR B CA  1 
ATOM   2256 C C   . TYR B 1 35  ? -7.513  30.913  -17.368 1.00 10.65 ? 60  TYR B C   1 
ATOM   2257 O O   . TYR B 1 35  ? -8.197  30.067  -16.785 1.00 9.50  ? 60  TYR B O   1 
ATOM   2258 C CB  . TYR B 1 35  ? -6.083  29.410  -18.756 1.00 10.58 ? 60  TYR B CB  1 
ATOM   2259 C CG  . TYR B 1 35  ? -6.698  29.787  -20.085 1.00 11.20 ? 60  TYR B CG  1 
ATOM   2260 C CD1 . TYR B 1 35  ? -5.986  30.552  -20.992 1.00 11.30 ? 60  TYR B CD1 1 
ATOM   2261 C CD2 . TYR B 1 35  ? -8.007  29.420  -20.414 1.00 11.93 ? 60  TYR B CD2 1 
ATOM   2262 C CE1 . TYR B 1 35  ? -6.541  30.933  -22.184 1.00 13.83 ? 60  TYR B CE1 1 
ATOM   2263 C CE2 . TYR B 1 35  ? -8.571  29.801  -21.611 1.00 11.88 ? 60  TYR B CE2 1 
ATOM   2264 C CZ  . TYR B 1 35  ? -7.826  30.541  -22.501 1.00 13.55 ? 60  TYR B CZ  1 
ATOM   2265 O OH  . TYR B 1 35  ? -8.380  30.930  -23.695 1.00 13.43 ? 60  TYR B OH  1 
ATOM   2266 N N   . ARG B 1 36  ? -7.968  32.125  -17.684 1.00 10.39 ? 61  ARG B N   1 
ATOM   2267 C CA  . ARG B 1 36  ? -9.243  32.630  -17.158 1.00 10.23 ? 61  ARG B CA  1 
ATOM   2268 C C   . ARG B 1 36  ? -9.328  32.441  -15.642 1.00 11.32 ? 61  ARG B C   1 
ATOM   2269 O O   . ARG B 1 36  ? -10.378 32.080  -15.091 1.00 10.91 ? 61  ARG B O   1 
ATOM   2270 C CB  . ARG B 1 36  ? -10.444 32.006  -17.866 1.00 8.93  ? 61  ARG B CB  1 
ATOM   2271 C CG  . ARG B 1 36  ? -10.467 32.286  -19.355 1.00 10.94 ? 61  ARG B CG  1 
ATOM   2272 C CD  . ARG B 1 36  ? -11.804 31.948  -20.004 1.00 11.44 ? 61  ARG B CD  1 
ATOM   2273 N NE  . ARG B 1 36  ? -11.706 31.988  -21.460 1.00 10.71 ? 61  ARG B NE  1 
ATOM   2274 C CZ  . ARG B 1 36  ? -11.669 33.104  -22.176 1.00 11.73 ? 61  ARG B CZ  1 
ATOM   2275 N NH1 . ARG B 1 36  ? -11.826 34.291  -21.612 1.00 11.94 ? 61  ARG B NH1 1 
ATOM   2276 N NH2 . ARG B 1 36  ? -11.441 33.028  -23.484 1.00 11.46 ? 61  ARG B NH2 1 
ATOM   2277 N N   . GLY B 1 37  ? -8.202  32.696  -14.963 1.00 11.03 ? 62  GLY B N   1 
ATOM   2278 C CA  . GLY B 1 37  ? -8.080  32.354  -13.554 1.00 11.10 ? 62  GLY B CA  1 
ATOM   2279 C C   . GLY B 1 37  ? -8.994  33.133  -12.636 1.00 10.99 ? 62  GLY B C   1 
ATOM   2280 O O   . GLY B 1 37  ? -9.329  32.653  -11.546 1.00 11.84 ? 62  GLY B O   1 
ATOM   2281 N N   . ASP B 1 38  ? -9.424  34.321  -13.057 1.00 10.80 ? 63  ASP B N   1 
ATOM   2282 C CA  . ASP B 1 38  ? -10.280 35.161  -12.233 1.00 10.59 ? 63  ASP B CA  1 
ATOM   2283 C C   . ASP B 1 38  ? -11.711 35.251  -12.751 1.00 9.38  ? 63  ASP B C   1 
ATOM   2284 O O   . ASP B 1 38  ? -12.494 36.075  -12.261 1.00 11.17 ? 63  ASP B O   1 
ATOM   2285 C CB  . ASP B 1 38  ? -9.643  36.541  -12.050 1.00 11.82 ? 63  ASP B CB  1 
ATOM   2286 C CG  . ASP B 1 38  ? -8.339  36.456  -11.314 1.00 14.78 ? 63  ASP B CG  1 
ATOM   2287 O OD1 . ASP B 1 38  ? -8.320  35.868  -10.204 1.00 14.28 ? 63  ASP B OD1 1 
ATOM   2288 O OD2 . ASP B 1 38  ? -7.326  36.949  -11.859 1.00 22.85 ? 63  ASP B OD2 1 
ATOM   2289 N N   . GLU B 1 39  ? -12.078 34.409  -13.719 1.00 11.54 ? 64  GLU B N   1 
ATOM   2290 C CA  . GLU B 1 39  ? -13.456 34.321  -14.180 1.00 8.19  ? 64  GLU B CA  1 
ATOM   2291 C C   . GLU B 1 39  ? -14.215 33.302  -13.329 1.00 11.03 ? 64  GLU B C   1 
ATOM   2292 O O   . GLU B 1 39  ? -13.648 32.315  -12.840 1.00 10.49 ? 64  GLU B O   1 
ATOM   2293 C CB  . GLU B 1 39  ? -13.508 33.901  -15.650 1.00 9.47  ? 64  GLU B CB  1 
ATOM   2294 C CG  . GLU B 1 39  ? -12.843 34.898  -16.625 1.00 10.97 ? 64  GLU B CG  1 
ATOM   2295 C CD  . GLU B 1 39  ? -13.117 34.577  -18.102 1.00 10.82 ? 64  GLU B CD  1 
ATOM   2296 O OE1 . GLU B 1 39  ? -14.090 33.858  -18.406 1.00 10.95 ? 64  GLU B OE1 1 
ATOM   2297 O OE2 . GLU B 1 39  ? -12.343 35.063  -18.959 1.00 12.35 ? 64  GLU B OE2 1 
ATOM   2298 N N   . ARG B 1 40  ? -15.509 33.543  -13.167 1.00 10.16 ? 65  ARG B N   1 
ATOM   2299 C CA  . ARG B 1 40  ? -16.355 32.676  -12.360 1.00 11.57 ? 65  ARG B CA  1 
ATOM   2300 C C   . ARG B 1 40  ? -16.903 31.512  -13.175 1.00 10.38 ? 65  ARG B C   1 
ATOM   2301 O O   . ARG B 1 40  ? -17.240 31.653  -14.358 1.00 10.81 ? 65  ARG B O   1 
ATOM   2302 C CB  . ARG B 1 40  ? -17.514 33.466  -11.742 1.00 8.94  ? 65  ARG B CB  1 
ATOM   2303 C CG  . ARG B 1 40  ? -17.080 34.243  -10.516 1.00 18.65 ? 65  ARG B CG  1 
ATOM   2304 C CD  . ARG B 1 40  ? -18.247 34.818  -9.727  1.00 14.91 ? 65  ARG B CD  1 
ATOM   2305 N NE  . ARG B 1 40  ? -17.753 35.494  -8.536  1.00 20.38 ? 65  ARG B NE  1 
ATOM   2306 C CZ  . ARG B 1 40  ? -17.543 34.922  -7.356  1.00 13.51 ? 65  ARG B CZ  1 
ATOM   2307 N NH1 . ARG B 1 40  ? -17.913 33.671  -7.110  1.00 10.44 ? 65  ARG B NH1 1 
ATOM   2308 N NH2 . ARG B 1 40  ? -16.969 35.633  -6.390  1.00 20.57 ? 65  ARG B NH2 1 
ATOM   2309 N N   . PHE B 1 41  ? -16.988 30.357  -12.526 1.00 9.19  ? 66  PHE B N   1 
ATOM   2310 C CA  . PHE B 1 41  ? -17.494 29.124  -13.109 1.00 8.96  ? 66  PHE B CA  1 
ATOM   2311 C C   . PHE B 1 41  ? -18.394 28.434  -12.094 1.00 9.41  ? 66  PHE B C   1 
ATOM   2312 O O   . PHE B 1 41  ? -18.156 28.535  -10.879 1.00 10.23 ? 66  PHE B O   1 
ATOM   2313 C CB  . PHE B 1 41  ? -16.345 28.147  -13.438 1.00 9.67  ? 66  PHE B CB  1 
ATOM   2314 C CG  . PHE B 1 41  ? -15.449 28.594  -14.565 1.00 7.87  ? 66  PHE B CG  1 
ATOM   2315 C CD1 . PHE B 1 41  ? -14.423 29.508  -14.357 1.00 9.96  ? 66  PHE B CD1 1 
ATOM   2316 C CD2 . PHE B 1 41  ? -15.622 28.066  -15.844 1.00 11.13 ? 66  PHE B CD2 1 
ATOM   2317 C CE1 . PHE B 1 41  ? -13.601 29.912  -15.429 1.00 9.13  ? 66  PHE B CE1 1 
ATOM   2318 C CE2 . PHE B 1 41  ? -14.801 28.457  -16.913 1.00 10.23 ? 66  PHE B CE2 1 
ATOM   2319 C CZ  . PHE B 1 41  ? -13.797 29.375  -16.702 1.00 9.23  ? 66  PHE B CZ  1 
ATOM   2320 N N   . PRO B 1 42  ? -19.410 27.698  -12.547 1.00 8.31  ? 67  PRO B N   1 
ATOM   2321 C CA  . PRO B 1 42  ? -20.225 26.925  -11.594 1.00 12.82 ? 67  PRO B CA  1 
ATOM   2322 C C   . PRO B 1 42  ? -19.438 25.741  -11.057 1.00 10.14 ? 67  PRO B C   1 
ATOM   2323 O O   . PRO B 1 42  ? -18.884 24.956  -11.831 1.00 14.32 ? 67  PRO B O   1 
ATOM   2324 C CB  . PRO B 1 42  ? -21.427 26.456  -12.424 1.00 12.73 ? 67  PRO B CB  1 
ATOM   2325 C CG  . PRO B 1 42  ? -21.221 26.934  -13.816 1.00 16.37 ? 67  PRO B CG  1 
ATOM   2326 C CD  . PRO B 1 42  ? -19.851 27.543  -13.946 1.00 13.30 ? 67  PRO B CD  1 
ATOM   2327 N N   . MET B 1 43  ? -19.425 25.593  -9.725  1.00 9.58  ? 68  MET B N   1 
ATOM   2328 C CA  . MET B 1 43  ? -18.625 24.524  -9.113  1.00 9.44  ? 68  MET B CA  1 
ATOM   2329 C C   . MET B 1 43  ? -19.228 23.138  -9.270  1.00 10.23 ? 68  MET B C   1 
ATOM   2330 O O   . MET B 1 43  ? -18.479 22.156  -9.368  1.00 10.34 ? 68  MET B O   1 
ATOM   2331 C CB  . MET B 1 43  ? -18.309 24.769  -7.640  1.00 11.45 ? 68  MET B CB  1 
ATOM   2332 C CG  . MET B 1 43  ? -17.632 26.070  -7.335  1.00 8.99  ? 68  MET B CG  1 
ATOM   2333 S SD  . MET B 1 43  ? -17.444 26.315  -5.556  1.00 10.76 ? 68  MET B SD  1 
ATOM   2334 C CE  . MET B 1 43  ? -19.021 27.069  -5.128  1.00 9.38  ? 68  MET B CE  1 
ATOM   2335 N N   . CYS B 1 44  ? -20.551 23.032  -9.266  1.00 9.28  ? 69  CYS B N   1 
ATOM   2336 C CA  . CYS B 1 44  ? -21.214 21.736  -9.218  1.00 9.33  ? 69  CYS B CA  1 
ATOM   2337 C C   . CYS B 1 44  ? -20.619 20.885  -8.095  1.00 10.01 ? 69  CYS B C   1 
ATOM   2338 O O   . CYS B 1 44  ? -20.375 21.405  -7.000  1.00 9.41  ? 69  CYS B O   1 
ATOM   2339 C CB  . CYS B 1 44  ? -21.194 21.063  -10.596 1.00 8.74  ? 69  CYS B CB  1 
ATOM   2340 S SG  . CYS B 1 44  ? -21.954 22.082  -11.898 1.00 11.26 ? 69  CYS B SG  1 
ATOM   2341 N N   . SER B 1 45  ? -20.353 19.597  -8.344  1.00 9.36  ? 70  SER B N   1 
ATOM   2342 C CA  . SER B 1 45  ? -19.948 18.682  -7.271  1.00 10.80 ? 70  SER B CA  1 
ATOM   2343 C C   . SER B 1 45  ? -18.574 18.993  -6.690  1.00 8.21  ? 70  SER B C   1 
ATOM   2344 O O   . SER B 1 45  ? -18.253 18.487  -5.607  1.00 8.48  ? 70  SER B O   1 
ATOM   2345 C CB  . SER B 1 45  ? -19.953 17.224  -7.753  1.00 7.79  ? 70  SER B CB  1 
ATOM   2346 O OG  . SER B 1 45  ? -21.270 16.697  -7.916  1.00 10.05 ? 70  SER B OG  1 
ATOM   2347 N N   . THR B 1 46  ? -17.750 19.809  -7.360  1.00 8.18  ? 71  THR B N   1 
ATOM   2348 C CA  . THR B 1 46  ? -16.479 20.174  -6.741  1.00 8.87  ? 71  THR B CA  1 
ATOM   2349 C C   . THR B 1 46  ? -16.678 20.970  -5.451  1.00 8.64  ? 71  THR B C   1 
ATOM   2350 O O   . THR B 1 46  ? -15.760 21.017  -4.628  1.00 11.02 ? 71  THR B O   1 
ATOM   2351 C CB  . THR B 1 46  ? -15.552 20.943  -7.696  1.00 10.13 ? 71  THR B CB  1 
ATOM   2352 O OG1 . THR B 1 46  ? -16.091 22.247  -7.987  1.00 10.73 ? 71  THR B OG1 1 
ATOM   2353 C CG2 . THR B 1 46  ? -15.327 20.166  -8.985  1.00 9.06  ? 71  THR B CG2 1 
ATOM   2354 N N   . SER B 1 47  ? -17.856 21.568  -5.246  1.00 8.45  ? 72  SER B N   1 
ATOM   2355 C CA  . SER B 1 47  ? -18.137 22.279  -3.999  1.00 9.36  ? 72  SER B CA  1 
ATOM   2356 C C   . SER B 1 47  ? -18.136 21.355  -2.788  1.00 7.27  ? 72  SER B C   1 
ATOM   2357 O O   . SER B 1 47  ? -18.038 21.832  -1.650  1.00 10.05 ? 72  SER B O   1 
ATOM   2358 C CB  . SER B 1 47  ? -19.491 23.002  -4.090  1.00 7.93  ? 72  SER B CB  1 
ATOM   2359 O OG  . SER B 1 47  ? -20.562 22.100  -4.301  1.00 11.06 ? 72  SER B OG  1 
ATOM   2360 N N   . LYS B 1 48  ? -18.251 20.047  -3.002  1.00 7.68  ? 73  LYS B N   1 
ATOM   2361 C CA  . LYS B 1 48  ? -18.324 19.100  -1.891  1.00 8.65  ? 73  LYS B CA  1 
ATOM   2362 C C   . LYS B 1 48  ? -17.040 19.062  -1.076  1.00 9.30  ? 73  LYS B C   1 
ATOM   2363 O O   . LYS B 1 48  ? -17.080 18.732  0.116   1.00 10.45 ? 73  LYS B O   1 
ATOM   2364 C CB  . LYS B 1 48  ? -18.673 17.709  -2.419  1.00 9.34  ? 73  LYS B CB  1 
ATOM   2365 C CG  . LYS B 1 48  ? -20.054 17.629  -3.056  1.00 8.73  ? 73  LYS B CG  1 
ATOM   2366 C CD  . LYS B 1 48  ? -20.334 16.268  -3.618  1.00 8.93  ? 73  LYS B CD  1 
ATOM   2367 C CE  . LYS B 1 48  ? -21.700 16.264  -4.294  1.00 10.38 ? 73  LYS B CE  1 
ATOM   2368 N NZ  . LYS B 1 48  ? -21.906 14.978  -4.974  1.00 10.71 ? 73  LYS B NZ  1 
ATOM   2369 N N   . VAL B 1 49  ? -15.901 19.407  -1.685  1.00 8.24  ? 74  VAL B N   1 
ATOM   2370 C CA  . VAL B 1 49  ? -14.654 19.468  -0.931  1.00 9.07  ? 74  VAL B CA  1 
ATOM   2371 C C   . VAL B 1 49  ? -14.736 20.522  0.167   1.00 8.96  ? 74  VAL B C   1 
ATOM   2372 O O   . VAL B 1 49  ? -14.277 20.298  1.295   1.00 9.48  ? 74  VAL B O   1 
ATOM   2373 C CB  . VAL B 1 49  ? -13.461 19.704  -1.869  1.00 8.46  ? 74  VAL B CB  1 
ATOM   2374 C CG1 . VAL B 1 49  ? -12.180 19.865  -1.031  1.00 11.19 ? 74  VAL B CG1 1 
ATOM   2375 C CG2 . VAL B 1 49  ? -13.326 18.579  -2.872  1.00 9.31  ? 74  VAL B CG2 1 
ATOM   2376 N N   . MET B 1 50  ? -15.297 21.689  -0.144  1.00 9.69  ? 75  MET B N   1 
ATOM   2377 C CA  . MET B 1 50  ? -15.394 22.724  0.882   1.00 9.98  ? 75  MET B CA  1 
ATOM   2378 C C   . MET B 1 50  ? -16.324 22.292  2.009   1.00 10.13 ? 75  MET B C   1 
ATOM   2379 O O   . MET B 1 50  ? -16.052 22.571  3.189   1.00 10.76 ? 75  MET B O   1 
ATOM   2380 C CB  . MET B 1 50  ? -15.896 24.027  0.256   1.00 9.04  ? 75  MET B CB  1 
ATOM   2381 C CG  . MET B 1 50  ? -15.755 25.233  1.143   1.00 9.84  ? 75  MET B CG  1 
ATOM   2382 S SD  . MET B 1 50  ? -14.059 25.856  1.361   1.00 12.50 ? 75  MET B SD  1 
ATOM   2383 C CE  . MET B 1 50  ? -13.863 26.709  -0.205  1.00 15.90 ? 75  MET B CE  1 
ATOM   2384 N N   . ALA B 1 51  ? -17.442 21.645  1.663   1.00 9.93  ? 76  ALA B N   1 
ATOM   2385 C CA  . ALA B 1 51  ? -18.390 21.203  2.676   1.00 8.50  ? 76  ALA B CA  1 
ATOM   2386 C C   . ALA B 1 51  ? -17.791 20.119  3.561   1.00 9.64  ? 76  ALA B C   1 
ATOM   2387 O O   . ALA B 1 51  ? -17.898 20.187  4.790   1.00 11.05 ? 76  ALA B O   1 
ATOM   2388 C CB  . ALA B 1 51  ? -19.683 20.727  2.021   1.00 10.69 ? 76  ALA B CB  1 
ATOM   2389 N N   . ALA B 1 52  ? -17.157 19.102  2.961   1.00 10.02 ? 77  ALA B N   1 
ATOM   2390 C CA  . ALA B 1 52  ? -16.510 18.078  3.781   1.00 7.66  ? 77  ALA B CA  1 
ATOM   2391 C C   . ALA B 1 52  ? -15.419 18.676  4.668   1.00 9.30  ? 77  ALA B C   1 
ATOM   2392 O O   . ALA B 1 52  ? -15.289 18.302  5.844   1.00 10.23 ? 77  ALA B O   1 
ATOM   2393 C CB  . ALA B 1 52  ? -15.972 16.946  2.903   1.00 10.62 ? 77  ALA B CB  1 
ATOM   2394 N N   . ALA B 1 53  ? -14.645 19.624  4.133   1.00 9.14  ? 78  ALA B N   1 
ATOM   2395 C CA  . ALA B 1 53  ? -13.585 20.246  4.916   1.00 9.21  ? 78  ALA B CA  1 
ATOM   2396 C C   . ALA B 1 53  ? -14.156 21.064  6.063   1.00 9.00  ? 78  ALA B C   1 
ATOM   2397 O O   . ALA B 1 53  ? -13.567 21.115  7.152   1.00 10.60 ? 78  ALA B O   1 
ATOM   2398 C CB  . ALA B 1 53  ? -12.713 21.115  4.016   1.00 12.58 ? 78  ALA B CB  1 
ATOM   2399 N N   . ALA B 1 54  ? -15.309 21.695  5.845   1.00 9.64  ? 79  ALA B N   1 
ATOM   2400 C CA  . ALA B 1 54  ? -15.924 22.481  6.904   1.00 8.44  ? 79  ALA B CA  1 
ATOM   2401 C C   . ALA B 1 54  ? -16.370 21.592  8.061   1.00 8.89  ? 79  ALA B C   1 
ATOM   2402 O O   . ALA B 1 54  ? -16.250 21.984  9.229   1.00 10.42 ? 79  ALA B O   1 
ATOM   2403 C CB  . ALA B 1 54  ? -17.090 23.289  6.344   1.00 9.22  ? 79  ALA B CB  1 
ATOM   2404 N N   . VAL B 1 55  ? -16.855 20.385  7.762   1.00 8.94  ? 80  VAL B N   1 
ATOM   2405 C CA  . VAL B 1 55  ? -17.229 19.448  8.815   1.00 11.01 ? 80  VAL B CA  1 
ATOM   2406 C C   . VAL B 1 55  ? -15.984 18.902  9.505   1.00 13.10 ? 80  VAL B C   1 
ATOM   2407 O O   . VAL B 1 55  ? -15.964 18.711  10.732  1.00 11.11 ? 80  VAL B O   1 
ATOM   2408 C CB  . VAL B 1 55  ? -18.141 18.343  8.245   1.00 9.71  ? 80  VAL B CB  1 
ATOM   2409 C CG1 . VAL B 1 55  ? -18.415 17.245  9.291   1.00 9.42  ? 80  VAL B CG1 1 
ATOM   2410 C CG2 . VAL B 1 55  ? -19.446 18.954  7.707   1.00 12.75 ? 80  VAL B CG2 1 
ATOM   2411 N N   . LEU B 1 56  ? -14.916 18.659  8.741   1.00 8.67  ? 81  LEU B N   1 
ATOM   2412 C CA  . LEU B 1 56  ? -13.662 18.258  9.372   1.00 8.86  ? 81  LEU B CA  1 
ATOM   2413 C C   . LEU B 1 56  ? -13.184 19.310  10.365  1.00 9.89  ? 81  LEU B C   1 
ATOM   2414 O O   . LEU B 1 56  ? -12.670 18.971  11.438  1.00 11.37 ? 81  LEU B O   1 
ATOM   2415 C CB  . LEU B 1 56  ? -12.595 17.985  8.313   1.00 10.05 ? 81  LEU B CB  1 
ATOM   2416 C CG  . LEU B 1 56  ? -12.701 16.651  7.573   1.00 8.67  ? 81  LEU B CG  1 
ATOM   2417 C CD1 . LEU B 1 56  ? -11.703 16.656  6.416   1.00 11.68 ? 81  LEU B CD1 1 
ATOM   2418 C CD2 . LEU B 1 56  ? -12.448 15.457  8.491   1.00 12.61 ? 81  LEU B CD2 1 
ATOM   2419 N N   . LYS B 1 57  ? -13.331 20.598  10.021  1.00 8.95  ? 82  LYS B N   1 
ATOM   2420 C CA  . LYS B 1 57  ? -12.906 21.648  10.946  1.00 7.90  ? 82  LYS B CA  1 
ATOM   2421 C C   . LYS B 1 57  ? -13.758 21.631  12.214  1.00 12.06 ? 82  LYS B C   1 
ATOM   2422 O O   . LYS B 1 57  ? -13.223 21.760  13.319  1.00 10.80 ? 82  LYS B O   1 
ATOM   2423 C CB  . LYS B 1 57  ? -12.932 23.012  10.255  1.00 10.52 ? 82  LYS B CB  1 
ATOM   2424 C CG  . LYS B 1 57  ? -12.686 24.224  11.172  1.00 10.14 ? 82  LYS B CG  1 
ATOM   2425 C CD  . LYS B 1 57  ? -11.328 24.191  11.862  1.00 11.82 ? 82  LYS B CD  1 
ATOM   2426 C CE  . LYS B 1 57  ? -10.191 24.321  10.846  1.00 12.64 ? 82  LYS B CE  1 
ATOM   2427 N NZ  . LYS B 1 57  ? -8.855  24.420  11.516  1.00 12.49 ? 82  LYS B NZ  1 
ATOM   2428 N N   . GLN B 1 58  ? -15.077 21.434  12.078  1.00 11.20 ? 83  GLN B N   1 
ATOM   2429 C CA  . GLN B 1 58  ? -15.930 21.267  13.256  1.00 13.42 ? 83  GLN B CA  1 
ATOM   2430 C C   . GLN B 1 58  ? -15.458 20.096  14.107  1.00 11.18 ? 83  GLN B C   1 
ATOM   2431 O O   . GLN B 1 58  ? -15.461 20.178  15.339  1.00 11.44 ? 83  GLN B O   1 
ATOM   2432 C CB  . GLN B 1 58  ? -17.383 21.020  12.839  1.00 9.21  ? 83  GLN B CB  1 
ATOM   2433 C CG  . GLN B 1 58  ? -18.171 22.210  12.296  1.00 10.08 ? 83  GLN B CG  1 
ATOM   2434 C CD  . GLN B 1 58  ? -19.562 21.773  11.895  1.00 11.12 ? 83  GLN B CD  1 
ATOM   2435 O OE1 . GLN B 1 58  ? -19.735 20.664  11.392  1.00 13.04 ? 83  GLN B OE1 1 
ATOM   2436 N NE2 . GLN B 1 58  ? -20.563 22.634  12.105  1.00 14.49 ? 83  GLN B NE2 1 
ATOM   2437 N N   . SER B 1 59  ? -15.031 18.996  13.467  1.00 10.77 ? 84  SER B N   1 
ATOM   2438 C CA  . SER B 1 59  ? -14.613 17.824  14.230  1.00 9.44  ? 84  SER B CA  1 
ATOM   2439 C C   . SER B 1 59  ? -13.352 18.066  15.045  1.00 12.79 ? 84  SER B C   1 
ATOM   2440 O O   . SER B 1 59  ? -13.074 17.282  15.954  1.00 11.77 ? 84  SER B O   1 
ATOM   2441 C CB  . SER B 1 59  ? -14.418 16.614  13.309  1.00 12.32 ? 84  SER B CB  1 
ATOM   2442 O OG  . SER B 1 59  ? -13.201 16.699  12.590  1.00 13.59 ? 84  SER B OG  1 
ATOM   2443 N N   . GLU B 1 60  ? -12.586 19.123  14.757  1.00 10.09 ? 85  GLU B N   1 
ATOM   2444 C CA  . GLU B 1 60  ? -11.371 19.365  15.534  1.00 11.57 ? 85  GLU B CA  1 
ATOM   2445 C C   . GLU B 1 60  ? -11.681 19.632  16.999  1.00 13.67 ? 85  GLU B C   1 
ATOM   2446 O O   . GLU B 1 60  ? -10.835 19.385  17.862  1.00 14.25 ? 85  GLU B O   1 
ATOM   2447 C CB  . GLU B 1 60  ? -10.565 20.519  14.939  1.00 11.37 ? 85  GLU B CB  1 
ATOM   2448 C CG  . GLU B 1 60  ? -10.006 20.188  13.587  1.00 11.08 ? 85  GLU B CG  1 
ATOM   2449 C CD  . GLU B 1 60  ? -9.282  21.332  12.924  1.00 14.01 ? 85  GLU B CD  1 
ATOM   2450 O OE1 . GLU B 1 60  ? -8.847  22.288  13.619  1.00 17.06 ? 85  GLU B OE1 1 
ATOM   2451 O OE2 . GLU B 1 60  ? -9.187  21.284  11.682  1.00 15.46 ? 85  GLU B OE2 1 
ATOM   2452 N N   . THR B 1 61  ? -12.873 20.133  17.307  1.00 11.52 ? 86  THR B N   1 
ATOM   2453 C CA  . THR B 1 61  ? -13.248 20.370  18.698  1.00 14.67 ? 86  THR B CA  1 
ATOM   2454 C C   . THR B 1 61  ? -14.289 19.381  19.211  1.00 11.41 ? 86  THR B C   1 
ATOM   2455 O O   . THR B 1 61  ? -14.842 19.594  20.293  1.00 12.61 ? 86  THR B O   1 
ATOM   2456 C CB  . THR B 1 61  ? -13.676 21.832  18.917  1.00 9.41  ? 86  THR B CB  1 
ATOM   2457 O OG1 . THR B 1 61  ? -14.691 22.192  17.965  1.00 13.05 ? 86  THR B OG1 1 
ATOM   2458 C CG2 . THR B 1 61  ? -12.482 22.770  18.756  1.00 13.74 ? 86  THR B CG2 1 
ATOM   2459 N N   . GLN B 1 62  ? -14.554 18.300  18.467  1.00 13.18 ? 87  GLN B N   1 
ATOM   2460 C CA  . GLN B 1 62  ? -15.564 17.300  18.833  1.00 13.61 ? 87  GLN B CA  1 
ATOM   2461 C C   . GLN B 1 62  ? -15.039 15.950  18.347  1.00 14.45 ? 87  GLN B C   1 
ATOM   2462 O O   . GLN B 1 62  ? -15.251 15.589  17.183  1.00 14.80 ? 87  GLN B O   1 
ATOM   2463 C CB  . GLN B 1 62  ? -16.896 17.620  18.174  1.00 12.66 ? 87  GLN B CB  1 
ATOM   2464 C CG  . GLN B 1 62  ? -17.649 18.795  18.749  1.00 13.85 ? 87  GLN B CG  1 
ATOM   2465 C CD  . GLN B 1 62  ? -19.022 18.954  18.121  1.00 14.52 ? 87  GLN B CD  1 
ATOM   2466 O OE1 . GLN B 1 62  ? -19.259 19.856  17.303  1.00 14.61 ? 87  GLN B OE1 1 
ATOM   2467 N NE2 . GLN B 1 62  ? -19.920 18.058  18.470  1.00 15.19 ? 87  GLN B NE2 1 
ATOM   2468 N N   . LYS B 1 63  ? -14.388 15.197  19.244  1.00 15.43 ? 88  LYS B N   1 
ATOM   2469 C CA  . LYS B 1 63  ? -13.730 13.950  18.846  1.00 14.90 ? 88  LYS B CA  1 
ATOM   2470 C C   . LYS B 1 63  ? -14.704 12.900  18.315  1.00 16.64 ? 88  LYS B C   1 
ATOM   2471 O O   . LYS B 1 63  ? -14.302 12.040  17.515  1.00 19.08 ? 88  LYS B O   1 
ATOM   2472 C CB  . LYS B 1 63  ? -12.832 13.442  19.990  1.00 17.37 ? 88  LYS B CB  1 
ATOM   2473 C CG  . LYS B 1 63  ? -12.526 11.935  20.028  1.00 20.54 ? 88  LYS B CG  1 
ATOM   2474 C CD  . LYS B 1 63  ? -12.222 11.494  21.461  1.00 30.04 ? 88  LYS B CD  1 
ATOM   2475 C CE  . LYS B 1 63  ? -12.905 10.187  21.841  1.00 33.46 ? 88  LYS B CE  1 
ATOM   2476 N NZ  . LYS B 1 63  ? -12.128 9.007   21.376  1.00 42.25 ? 88  LYS B NZ  1 
ATOM   2477 N N   . GLN B 1 64  ? -15.980 12.977  18.678  1.00 15.20 ? 89  GLN B N   1 
ATOM   2478 C CA  . GLN B 1 64  ? -16.968 12.006  18.232  1.00 15.43 ? 89  GLN B CA  1 
ATOM   2479 C C   . GLN B 1 64  ? -17.891 12.526  17.132  1.00 15.55 ? 89  GLN B C   1 
ATOM   2480 O O   . GLN B 1 64  ? -18.841 11.822  16.764  1.00 17.52 ? 89  GLN B O   1 
ATOM   2481 C CB  . GLN B 1 64  ? -17.798 11.486  19.411  1.00 16.90 ? 89  GLN B CB  1 
ATOM   2482 C CG  . GLN B 1 64  ? -17.005 10.613  20.379  1.00 25.15 ? 89  GLN B CG  1 
ATOM   2483 C CD  . GLN B 1 64  ? -16.543 9.307   19.750  1.00 23.83 ? 89  GLN B CD  1 
ATOM   2484 O OE1 . GLN B 1 64  ? -15.362 8.959   19.818  1.00 43.98 ? 89  GLN B OE1 1 
ATOM   2485 N NE2 . GLN B 1 64  ? -17.470 8.580   19.131  1.00 29.15 ? 89  GLN B NE2 1 
ATOM   2486 N N   . LEU B 1 65  ? -17.627 13.717  16.581  1.00 14.48 ? 90  LEU B N   1 
ATOM   2487 C CA  . LEU B 1 65  ? -18.538 14.285  15.585  1.00 14.29 ? 90  LEU B CA  1 
ATOM   2488 C C   . LEU B 1 65  ? -18.643 13.398  14.349  1.00 12.19 ? 90  LEU B C   1 
ATOM   2489 O O   . LEU B 1 65  ? -19.743 13.178  13.829  1.00 12.92 ? 90  LEU B O   1 
ATOM   2490 C CB  . LEU B 1 65  ? -18.103 15.701  15.196  1.00 12.44 ? 90  LEU B CB  1 
ATOM   2491 C CG  . LEU B 1 65  ? -18.967 16.391  14.138  1.00 11.18 ? 90  LEU B CG  1 
ATOM   2492 C CD1 . LEU B 1 65  ? -20.365 16.588  14.665  1.00 15.29 ? 90  LEU B CD1 1 
ATOM   2493 C CD2 . LEU B 1 65  ? -18.338 17.724  13.772  1.00 13.39 ? 90  LEU B CD2 1 
ATOM   2494 N N   . LEU B 1 66  ? -17.512 12.889  13.857  1.00 13.12 ? 91  LEU B N   1 
ATOM   2495 C CA  . LEU B 1 66  ? -17.548 12.074  12.649  1.00 11.26 ? 91  LEU B CA  1 
ATOM   2496 C C   . LEU B 1 66  ? -18.321 10.771  12.851  1.00 11.66 ? 91  LEU B C   1 
ATOM   2497 O O   . LEU B 1 66  ? -18.757 10.164  11.867  1.00 11.72 ? 91  LEU B O   1 
ATOM   2498 C CB  . LEU B 1 66  ? -16.129 11.829  12.139  1.00 12.36 ? 91  LEU B CB  1 
ATOM   2499 C CG  . LEU B 1 66  ? -15.453 13.093  11.593  1.00 11.96 ? 91  LEU B CG  1 
ATOM   2500 C CD1 . LEU B 1 66  ? -14.094 12.763  10.991  1.00 19.33 ? 91  LEU B CD1 1 
ATOM   2501 C CD2 . LEU B 1 66  ? -16.352 13.746  10.551  1.00 16.25 ? 91  LEU B CD2 1 
ATOM   2502 N N   . ASN B 1 67  ? -18.530 10.344  14.093  1.00 11.71 ? 92  ASN B N   1 
ATOM   2503 C CA  . ASN B 1 67  ? -19.325 9.157   14.365  1.00 11.64 ? 92  ASN B CA  1 
ATOM   2504 C C   . ASN B 1 67  ? -20.784 9.459   14.670  1.00 12.82 ? 92  ASN B C   1 
ATOM   2505 O O   . ASN B 1 67  ? -21.536 8.539   15.003  1.00 15.96 ? 92  ASN B O   1 
ATOM   2506 C CB  . ASN B 1 67  ? -18.703 8.344   15.504  1.00 12.43 ? 92  ASN B CB  1 
ATOM   2507 C CG  . ASN B 1 67  ? -17.321 7.835   15.158  1.00 15.63 ? 92  ASN B CG  1 
ATOM   2508 O OD1 . ASN B 1 67  ? -17.046 7.458   14.013  1.00 17.07 ? 92  ASN B OD1 1 
ATOM   2509 N ND2 . ASN B 1 67  ? -16.439 7.823   16.142  1.00 24.15 ? 92  ASN B ND2 1 
ATOM   2510 N N   . GLN B 1 68  ? -21.206 10.701  14.556  1.00 12.32 ? 93  GLN B N   1 
ATOM   2511 C CA  . GLN B 1 68  ? -22.563 11.057  14.939  1.00 14.15 ? 93  GLN B CA  1 
ATOM   2512 C C   . GLN B 1 68  ? -23.535 10.629  13.841  1.00 14.46 ? 93  GLN B C   1 
ATOM   2513 O O   . GLN B 1 68  ? -23.286 10.901  12.664  1.00 13.27 ? 93  GLN B O   1 
ATOM   2514 C CB  . GLN B 1 68  ? -22.610 12.569  15.168  1.00 16.23 ? 93  GLN B CB  1 
ATOM   2515 C CG  . GLN B 1 68  ? -23.960 13.199  15.406  1.00 21.10 ? 93  GLN B CG  1 
ATOM   2516 C CD  . GLN B 1 68  ? -23.809 14.665  15.762  1.00 15.02 ? 93  GLN B CD  1 
ATOM   2517 O OE1 . GLN B 1 68  ? -22.990 15.020  16.616  1.00 19.04 ? 93  GLN B OE1 1 
ATOM   2518 N NE2 . GLN B 1 68  ? -24.569 15.521  15.089  1.00 23.00 ? 93  GLN B NE2 1 
ATOM   2519 N N   . PRO B 1 69  ? -24.616 9.930   14.177  1.00 14.14 ? 94  PRO B N   1 
ATOM   2520 C CA  . PRO B 1 69  ? -25.552 9.477   13.142  1.00 14.74 ? 94  PRO B CA  1 
ATOM   2521 C C   . PRO B 1 69  ? -26.444 10.599  12.648  1.00 13.57 ? 94  PRO B C   1 
ATOM   2522 O O   . PRO B 1 69  ? -26.803 11.519  13.387  1.00 17.72 ? 94  PRO B O   1 
ATOM   2523 C CB  . PRO B 1 69  ? -26.414 8.428   13.857  1.00 15.45 ? 94  PRO B CB  1 
ATOM   2524 C CG  . PRO B 1 69  ? -25.969 8.385   15.259  1.00 31.22 ? 94  PRO B CG  1 
ATOM   2525 C CD  . PRO B 1 69  ? -24.718 9.157   15.422  1.00 20.41 ? 94  PRO B CD  1 
ATOM   2526 N N   . VAL B 1 70  ? -26.808 10.496  11.367  1.00 13.10 ? 95  VAL B N   1 
ATOM   2527 C CA  . VAL B 1 70  ? -27.727 11.417  10.705  1.00 13.68 ? 95  VAL B CA  1 
ATOM   2528 C C   . VAL B 1 70  ? -28.807 10.580  10.029  1.00 12.90 ? 95  VAL B C   1 
ATOM   2529 O O   . VAL B 1 70  ? -28.492 9.646   9.281   1.00 12.88 ? 95  VAL B O   1 
ATOM   2530 C CB  . VAL B 1 70  ? -26.983 12.295  9.678   1.00 10.39 ? 95  VAL B CB  1 
ATOM   2531 C CG1 . VAL B 1 70  ? -27.964 13.149  8.893   1.00 12.68 ? 95  VAL B CG1 1 
ATOM   2532 C CG2 . VAL B 1 70  ? -25.978 13.174  10.383  1.00 13.19 ? 95  VAL B CG2 1 
ATOM   2533 N N   . GLU B 1 71  ? -30.074 10.889  10.310  1.00 12.16 ? 96  GLU B N   1 
ATOM   2534 C CA  . GLU B 1 71  ? -31.158 10.118  9.711   1.00 13.27 ? 96  GLU B CA  1 
ATOM   2535 C C   . GLU B 1 71  ? -31.322 10.433  8.228   1.00 10.42 ? 96  GLU B C   1 
ATOM   2536 O O   . GLU B 1 71  ? -31.285 11.596  7.808   1.00 12.94 ? 96  GLU B O   1 
ATOM   2537 C CB  . GLU B 1 71  ? -32.489 10.353  10.428  1.00 14.56 ? 96  GLU B CB  1 
ATOM   2538 C CG  . GLU B 1 71  ? -32.493 9.992   11.889  1.00 19.50 ? 96  GLU B CG  1 
ATOM   2539 C CD  . GLU B 1 71  ? -33.799 10.378  12.565  1.00 32.44 ? 96  GLU B CD  1 
ATOM   2540 O OE1 . GLU B 1 71  ? -34.623 11.069  11.924  1.00 37.61 ? 96  GLU B OE1 1 
ATOM   2541 O OE2 . GLU B 1 71  ? -34.006 9.984   13.731  1.00 36.39 ? 96  GLU B OE2 1 
ATOM   2542 N N   . ILE B 1 72  ? -31.498 9.380   7.433   1.00 13.33 ? 97  ILE B N   1 
ATOM   2543 C CA  . ILE B 1 72  ? -31.818 9.478   6.012   1.00 12.75 ? 97  ILE B CA  1 
ATOM   2544 C C   . ILE B 1 72  ? -33.263 9.038   5.842   1.00 11.96 ? 97  ILE B C   1 
ATOM   2545 O O   . ILE B 1 72  ? -33.617 7.914   6.216   1.00 14.00 ? 97  ILE B O   1 
ATOM   2546 C CB  . ILE B 1 72  ? -30.906 8.586   5.156   1.00 10.31 ? 97  ILE B CB  1 
ATOM   2547 C CG1 . ILE B 1 72  ? -29.435 8.694   5.572   1.00 17.13 ? 97  ILE B CG1 1 
ATOM   2548 C CG2 . ILE B 1 72  ? -31.088 8.901   3.672   1.00 14.15 ? 97  ILE B CG2 1 
ATOM   2549 C CD1 . ILE B 1 72  ? -28.827 10.054  5.390   1.00 13.51 ? 97  ILE B CD1 1 
ATOM   2550 N N   . LYS B 1 73  ? -34.084 9.900   5.261   1.00 15.86 ? 98  LYS B N   1 
ATOM   2551 C CA  . LYS B 1 73  ? -35.493 9.638   5.025   1.00 14.04 ? 98  LYS B CA  1 
ATOM   2552 C C   . LYS B 1 73  ? -35.785 9.607   3.529   1.00 17.14 ? 98  LYS B C   1 
ATOM   2553 O O   . LYS B 1 73  ? -35.031 10.171  2.728   1.00 16.32 ? 98  LYS B O   1 
ATOM   2554 C CB  . LYS B 1 73  ? -36.343 10.726  5.693   1.00 13.71 ? 98  LYS B CB  1 
ATOM   2555 C CG  . LYS B 1 73  ? -36.298 10.722  7.213   1.00 18.43 ? 98  LYS B CG  1 
ATOM   2556 C CD  . LYS B 1 73  ? -36.450 9.320   7.798   1.00 30.12 ? 98  LYS B CD  1 
ATOM   2557 C CE  . LYS B 1 73  ? -36.759 9.396   9.298   1.00 30.77 ? 98  LYS B CE  1 
ATOM   2558 N NZ  . LYS B 1 73  ? -36.558 8.097   9.996   1.00 25.40 ? 98  LYS B NZ  1 
ATOM   2559 N N   . PRO B 1 74  ? -36.872 8.949   3.116   1.00 17.91 ? 99  PRO B N   1 
ATOM   2560 C CA  . PRO B 1 74  ? -37.209 8.924   1.684   1.00 18.71 ? 99  PRO B CA  1 
ATOM   2561 C C   . PRO B 1 74  ? -37.237 10.294  1.027   1.00 17.13 ? 99  PRO B C   1 
ATOM   2562 O O   . PRO B 1 74  ? -36.748 10.434  -0.099  1.00 19.28 ? 99  PRO B O   1 
ATOM   2563 C CB  . PRO B 1 74  ? -38.581 8.243   1.667   1.00 19.12 ? 99  PRO B CB  1 
ATOM   2564 C CG  . PRO B 1 74  ? -38.557 7.356   2.852   1.00 23.45 ? 99  PRO B CG  1 
ATOM   2565 C CD  . PRO B 1 74  ? -37.797 8.122   3.912   1.00 16.50 ? 99  PRO B CD  1 
ATOM   2566 N N   . ALA B 1 75  ? -37.771 11.319  1.705   1.00 17.22 ? 100 ALA B N   1 
ATOM   2567 C CA  . ALA B 1 75  ? -37.807 12.655  1.120   1.00 21.97 ? 100 ALA B CA  1 
ATOM   2568 C C   . ALA B 1 75  ? -36.419 13.256  0.899   1.00 17.55 ? 100 ALA B C   1 
ATOM   2569 O O   . ALA B 1 75  ? -36.291 14.225  0.145   1.00 22.59 ? 100 ALA B O   1 
ATOM   2570 C CB  . ALA B 1 75  ? -38.659 13.585  1.985   1.00 20.64 ? 100 ALA B CB  1 
ATOM   2571 N N   . ASP B 1 76  ? -35.372 12.717  1.535   1.00 16.26 ? 101 ASP B N   1 
ATOM   2572 C CA  . ASP B 1 76  ? -34.036 13.286  1.383   1.00 13.96 ? 101 ASP B CA  1 
ATOM   2573 C C   . ASP B 1 76  ? -33.363 12.871  0.089   1.00 13.16 ? 101 ASP B C   1 
ATOM   2574 O O   . ASP B 1 76  ? -32.324 13.449  -0.258  1.00 15.36 ? 101 ASP B O   1 
ATOM   2575 C CB  . ASP B 1 76  ? -33.120 12.813  2.509   1.00 13.45 ? 101 ASP B CB  1 
ATOM   2576 C CG  . ASP B 1 76  ? -33.579 13.270  3.869   1.00 15.71 ? 101 ASP B CG  1 
ATOM   2577 O OD1 . ASP B 1 76  ? -34.271 14.299  3.950   1.00 21.18 ? 101 ASP B OD1 1 
ATOM   2578 O OD2 . ASP B 1 76  ? -33.271 12.584  4.857   1.00 14.04 ? 101 ASP B OD2 1 
ATOM   2579 N N   . LEU B 1 77  ? -33.877 11.852  -0.591  1.00 12.01 ? 102 LEU B N   1 
ATOM   2580 C CA  . LEU B 1 77  ? -33.250 11.424  -1.831  1.00 10.80 ? 102 LEU B CA  1 
ATOM   2581 C C   . LEU B 1 77  ? -33.494 12.473  -2.908  1.00 11.76 ? 102 LEU B C   1 
ATOM   2582 O O   . LEU B 1 77  ? -34.577 13.056  -2.996  1.00 17.26 ? 102 LEU B O   1 
ATOM   2583 C CB  . LEU B 1 77  ? -33.789 10.061  -2.250  1.00 14.96 ? 102 LEU B CB  1 
ATOM   2584 C CG  . LEU B 1 77  ? -33.553 8.936   -1.240  1.00 14.32 ? 102 LEU B CG  1 
ATOM   2585 C CD1 . LEU B 1 77  ? -34.018 7.625   -1.849  1.00 14.71 ? 102 LEU B CD1 1 
ATOM   2586 C CD2 . LEU B 1 77  ? -32.097 8.840   -0.799  1.00 13.39 ? 102 LEU B CD2 1 
ATOM   2587 N N   . VAL B 1 78  ? -32.453 12.740  -3.698  1.00 13.16 ? 103 VAL B N   1 
ATOM   2588 C CA  . VAL B 1 78  ? -32.502 13.721  -4.778  1.00 10.38 ? 103 VAL B CA  1 
ATOM   2589 C C   . VAL B 1 78  ? -32.207 13.024  -6.105  1.00 14.65 ? 103 VAL B C   1 
ATOM   2590 O O   . VAL B 1 78  ? -32.776 11.964  -6.381  1.00 18.73 ? 103 VAL B O   1 
ATOM   2591 C CB  . VAL B 1 78  ? -31.602 14.939  -4.480  1.00 10.07 ? 103 VAL B CB  1 
ATOM   2592 C CG1 . VAL B 1 78  ? -32.254 15.787  -3.412  1.00 14.21 ? 103 VAL B CG1 1 
ATOM   2593 C CG2 . VAL B 1 78  ? -30.213 14.515  -4.038  1.00 14.27 ? 103 VAL B CG2 1 
ATOM   2594 N N   . ASN B 1 79  ? -31.319 13.593  -6.935  1.00 14.50 ? 104 ASN B N   1 
ATOM   2595 C CA  . ASN B 1 79  ? -31.122 13.104  -8.301  1.00 13.62 ? 104 ASN B CA  1 
ATOM   2596 C C   . ASN B 1 79  ? -30.038 12.041  -8.435  1.00 14.37 ? 104 ASN B C   1 
ATOM   2597 O O   . ASN B 1 79  ? -30.065 11.273  -9.400  1.00 17.88 ? 104 ASN B O   1 
ATOM   2598 C CB  . ASN B 1 79  ? -30.776 14.266  -9.237  1.00 9.96  ? 104 ASN B CB  1 
ATOM   2599 C CG  . ASN B 1 79  ? -29.480 14.950  -8.854  1.00 13.70 ? 104 ASN B CG  1 
ATOM   2600 O OD1 . ASN B 1 79  ? -29.244 15.239  -7.687  1.00 11.58 ? 104 ASN B OD1 1 
ATOM   2601 N ND2 . ASN B 1 79  ? -28.640 15.237  -9.848  1.00 18.05 ? 104 ASN B ND2 1 
ATOM   2602 N N   . TYR B 1 80  ? -29.085 11.983  -7.513  1.00 11.81 ? 105 TYR B N   1 
ATOM   2603 C CA  . TYR B 1 80  ? -27.999 11.014  -7.591  1.00 14.16 ? 105 TYR B CA  1 
ATOM   2604 C C   . TYR B 1 80  ? -27.561 10.723  -6.166  1.00 12.35 ? 105 TYR B C   1 
ATOM   2605 O O   . TYR B 1 80  ? -26.946 11.580  -5.515  1.00 14.86 ? 105 TYR B O   1 
ATOM   2606 C CB  . TYR B 1 80  ? -26.830 11.536  -8.429  1.00 13.27 ? 105 TYR B CB  1 
ATOM   2607 C CG  . TYR B 1 80  ? -25.787 10.474  -8.611  1.00 16.23 ? 105 TYR B CG  1 
ATOM   2608 C CD1 . TYR B 1 80  ? -26.041 9.380   -9.432  1.00 20.49 ? 105 TYR B CD1 1 
ATOM   2609 C CD2 . TYR B 1 80  ? -24.545 10.569  -7.999  1.00 14.03 ? 105 TYR B CD2 1 
ATOM   2610 C CE1 . TYR B 1 80  ? -25.109 8.387   -9.606  1.00 24.06 ? 105 TYR B CE1 1 
ATOM   2611 C CE2 . TYR B 1 80  ? -23.588 9.582   -8.178  1.00 12.63 ? 105 TYR B CE2 1 
ATOM   2612 C CZ  . TYR B 1 80  ? -23.883 8.491   -8.979  1.00 19.12 ? 105 TYR B CZ  1 
ATOM   2613 O OH  . TYR B 1 80  ? -22.970 7.485   -9.178  1.00 17.44 ? 105 TYR B OH  1 
ATOM   2614 N N   . ASN B 1 81  ? -27.879 9.533   -5.677  1.00 14.40 ? 106 ASN B N   1 
ATOM   2615 C CA  . ASN B 1 81  ? -27.579 9.237   -4.278  1.00 12.73 ? 106 ASN B CA  1 
ATOM   2616 C C   . ASN B 1 81  ? -27.370 7.742   -4.112  1.00 12.67 ? 106 ASN B C   1 
ATOM   2617 O O   . ASN B 1 81  ? -28.122 7.088   -3.376  1.00 13.91 ? 106 ASN B O   1 
ATOM   2618 C CB  . ASN B 1 81  ? -28.733 9.693   -3.377  1.00 17.48 ? 106 ASN B CB  1 
ATOM   2619 C CG  . ASN B 1 81  ? -30.036 9.868   -4.132  1.00 16.89 ? 106 ASN B CG  1 
ATOM   2620 O OD1 . ASN B 1 81  ? -30.445 10.985  -4.422  1.00 21.82 ? 106 ASN B OD1 1 
ATOM   2621 N ND2 . ASN B 1 81  ? -30.701 8.763   -4.434  1.00 24.23 ? 106 ASN B ND2 1 
ATOM   2622 N N   . PRO B 1 82  ? -26.356 7.165   -4.766  1.00 10.97 ? 107 PRO B N   1 
ATOM   2623 C CA  . PRO B 1 82  ? -26.175 5.707   -4.695  1.00 14.98 ? 107 PRO B CA  1 
ATOM   2624 C C   . PRO B 1 82  ? -25.888 5.170   -3.304  1.00 13.24 ? 107 PRO B C   1 
ATOM   2625 O O   . PRO B 1 82  ? -26.245 4.019   -3.025  1.00 15.22 ? 107 PRO B O   1 
ATOM   2626 C CB  . PRO B 1 82  ? -25.016 5.447   -5.663  1.00 18.30 ? 107 PRO B CB  1 
ATOM   2627 C CG  . PRO B 1 82  ? -24.247 6.717   -5.661  1.00 14.80 ? 107 PRO B CG  1 
ATOM   2628 C CD  . PRO B 1 82  ? -25.284 7.819   -5.534  1.00 11.74 ? 107 PRO B CD  1 
ATOM   2629 N N   . ILE B 1 83  ? -25.278 5.949   -2.416  1.00 10.45 ? 108 ILE B N   1 
ATOM   2630 C CA  . ILE B 1 83  ? -24.973 5.446   -1.078  1.00 10.15 ? 108 ILE B CA  1 
ATOM   2631 C C   . ILE B 1 83  ? -26.126 5.692   -0.117  1.00 10.83 ? 108 ILE B C   1 
ATOM   2632 O O   . ILE B 1 83  ? -26.551 4.779   0.605   1.00 10.59 ? 108 ILE B O   1 
ATOM   2633 C CB  . ILE B 1 83  ? -23.652 6.025   -0.543  1.00 9.95  ? 108 ILE B CB  1 
ATOM   2634 C CG1 . ILE B 1 83  ? -22.526 5.901   -1.571  1.00 9.81  ? 108 ILE B CG1 1 
ATOM   2635 C CG2 . ILE B 1 83  ? -23.282 5.379   0.785   1.00 9.57  ? 108 ILE B CG2 1 
ATOM   2636 C CD1 . ILE B 1 83  ? -22.269 4.472   -2.126  1.00 11.79 ? 108 ILE B CD1 1 
ATOM   2637 N N   . ALA B 1 84  ? -26.660 6.919   -0.107  1.00 11.47 ? 109 ALA B N   1 
ATOM   2638 C CA  . ALA B 1 84  ? -27.710 7.270   0.843   1.00 9.43  ? 109 ALA B CA  1 
ATOM   2639 C C   . ALA B 1 84  ? -28.979 6.448   0.644   1.00 11.76 ? 109 ALA B C   1 
ATOM   2640 O O   . ALA B 1 84  ? -29.674 6.158   1.627   1.00 12.32 ? 109 ALA B O   1 
ATOM   2641 C CB  . ALA B 1 84  ? -28.042 8.764   0.766   1.00 12.15 ? 109 ALA B CB  1 
ATOM   2642 N N   . GLU B 1 85  ? -29.302 6.059   -0.597  1.00 12.36 ? 110 GLU B N   1 
ATOM   2643 C CA  . GLU B 1 85  ? -30.535 5.298   -0.775  1.00 11.24 ? 110 GLU B CA  1 
ATOM   2644 C C   . GLU B 1 85  ? -30.460 3.928   -0.117  1.00 12.14 ? 110 GLU B C   1 
ATOM   2645 O O   . GLU B 1 85  ? -31.508 3.358   0.216   1.00 14.03 ? 110 GLU B O   1 
ATOM   2646 C CB  . GLU B 1 85  ? -30.931 5.177   -2.251  1.00 13.98 ? 110 GLU B CB  1 
ATOM   2647 C CG  . GLU B 1 85  ? -29.950 4.411   -3.088  1.00 15.75 ? 110 GLU B CG  1 
ATOM   2648 C CD  . GLU B 1 85  ? -30.299 4.434   -4.568  1.00 22.40 ? 110 GLU B CD  1 
ATOM   2649 O OE1 . GLU B 1 85  ? -31.189 5.210   -4.960  1.00 20.69 ? 110 GLU B OE1 1 
ATOM   2650 O OE2 . GLU B 1 85  ? -29.664 3.685   -5.340  1.00 21.38 ? 110 GLU B OE2 1 
ATOM   2651 N N   . LYS B 1 86  ? -29.252 3.393   0.095   1.00 11.02 ? 111 LYS B N   1 
ATOM   2652 C CA  . LYS B 1 86  ? -29.107 2.144   0.835   1.00 12.65 ? 111 LYS B CA  1 
ATOM   2653 C C   . LYS B 1 86  ? -29.419 2.300   2.321   1.00 11.34 ? 111 LYS B C   1 
ATOM   2654 O O   . LYS B 1 86  ? -29.606 1.291   3.013   1.00 12.33 ? 111 LYS B O   1 
ATOM   2655 C CB  . LYS B 1 86  ? -27.672 1.649   0.714   1.00 13.52 ? 111 LYS B CB  1 
ATOM   2656 C CG  . LYS B 1 86  ? -27.267 1.173   -0.652  1.00 17.01 ? 111 LYS B CG  1 
ATOM   2657 C CD  . LYS B 1 86  ? -25.946 0.470   -0.477  0.75 23.87 ? 111 LYS B CD  1 
ATOM   2658 C CE  . LYS B 1 86  ? -24.794 1.303   -0.983  1.00 20.55 ? 111 LYS B CE  1 
ATOM   2659 N NZ  . LYS B 1 86  ? -23.774 0.476   -1.690  1.00 19.89 ? 111 LYS B NZ  1 
ATOM   2660 N N   . HIS B 1 87  ? -29.494 3.530   2.822   1.00 12.45 ? 112 HIS B N   1 
ATOM   2661 C CA  . HIS B 1 87  ? -29.666 3.796   4.240   1.00 10.18 ? 112 HIS B CA  1 
ATOM   2662 C C   . HIS B 1 87  ? -30.953 4.542   4.541   1.00 12.23 ? 112 HIS B C   1 
ATOM   2663 O O   . HIS B 1 87  ? -31.113 5.062   5.656   1.00 12.94 ? 112 HIS B O   1 
ATOM   2664 C CB  . HIS B 1 87  ? -28.460 4.576   4.763   1.00 11.05 ? 112 HIS B CB  1 
ATOM   2665 C CG  . HIS B 1 87  ? -27.166 3.856   4.551   1.00 13.29 ? 112 HIS B CG  1 
ATOM   2666 N ND1 . HIS B 1 87  ? -26.781 2.785   5.328   1.00 26.72 ? 112 HIS B ND1 1 
ATOM   2667 C CD2 . HIS B 1 87  ? -26.187 4.026   3.633   1.00 12.73 ? 112 HIS B CD2 1 
ATOM   2668 C CE1 . HIS B 1 87  ? -25.608 2.341   4.911   1.00 27.35 ? 112 HIS B CE1 1 
ATOM   2669 N NE2 . HIS B 1 87  ? -25.225 3.078   3.884   1.00 17.12 ? 112 HIS B NE2 1 
ATOM   2670 N N   . VAL B 1 88  ? -31.882 4.591   3.579   1.00 9.88  ? 113 VAL B N   1 
ATOM   2671 C CA  . VAL B 1 88  ? -33.161 5.248   3.811   1.00 10.32 ? 113 VAL B CA  1 
ATOM   2672 C C   . VAL B 1 88  ? -33.902 4.526   4.928   1.00 14.12 ? 113 VAL B C   1 
ATOM   2673 O O   . VAL B 1 88  ? -33.918 3.288   4.998   1.00 12.80 ? 113 VAL B O   1 
ATOM   2674 C CB  . VAL B 1 88  ? -33.976 5.255   2.506   1.00 14.99 ? 113 VAL B CB  1 
ATOM   2675 C CG1 . VAL B 1 88  ? -35.393 5.708   2.772   1.00 22.94 ? 113 VAL B CG1 1 
ATOM   2676 C CG2 . VAL B 1 88  ? -33.327 6.180   1.501   1.00 16.43 ? 113 VAL B CG2 1 
ATOM   2677 N N   . ASN B 1 89  ? -34.522 5.305   5.814   1.00 13.97 ? 114 ASN B N   1 
ATOM   2678 C CA  . ASN B 1 89  ? -35.118 4.840   7.061   1.00 13.43 ? 114 ASN B CA  1 
ATOM   2679 C C   . ASN B 1 89  ? -34.081 4.399   8.076   1.00 16.58 ? 114 ASN B C   1 
ATOM   2680 O O   . ASN B 1 89  ? -34.433 3.829   9.114   1.00 17.87 ? 114 ASN B O   1 
ATOM   2681 C CB  . ASN B 1 89  ? -36.213 3.789   6.849   1.00 15.69 ? 114 ASN B CB  1 
ATOM   2682 C CG  . ASN B 1 89  ? -37.360 4.334   6.069   1.00 12.28 ? 114 ASN B CG  1 
ATOM   2683 O OD1 . ASN B 1 89  ? -37.812 5.453   6.322   1.00 18.60 ? 114 ASN B OD1 1 
ATOM   2684 N ND2 . ASN B 1 89  ? -37.828 3.573   5.082   1.00 14.69 ? 114 ASN B ND2 1 
ATOM   2685 N N   . GLY B 1 90  ? -32.812 4.688   7.820   1.00 15.32 ? 115 GLY B N   1 
ATOM   2686 C CA  . GLY B 1 90  ? -31.716 4.401   8.714   1.00 12.29 ? 115 GLY B CA  1 
ATOM   2687 C C   . GLY B 1 90  ? -30.878 5.648   8.930   1.00 10.18 ? 115 GLY B C   1 
ATOM   2688 O O   . GLY B 1 90  ? -31.367 6.769   8.841   1.00 16.84 ? 115 GLY B O   1 
ATOM   2689 N N   . THR B 1 91  ? -29.602 5.430   9.241   1.00 13.18 ? 116 THR B N   1 
ATOM   2690 C CA  . THR B 1 91  ? -28.694 6.532   9.516   1.00 12.69 ? 116 THR B CA  1 
ATOM   2691 C C   . THR B 1 91  ? -27.357 6.291   8.844   1.00 14.94 ? 116 THR B C   1 
ATOM   2692 O O   . THR B 1 91  ? -27.011 5.174   8.429   1.00 13.45 ? 116 THR B O   1 
ATOM   2693 C CB  . THR B 1 91  ? -28.409 6.713   11.012  1.00 16.64 ? 116 THR B CB  1 
ATOM   2694 O OG1 . THR B 1 91  ? -27.899 5.493   11.550  1.00 14.83 ? 116 THR B OG1 1 
ATOM   2695 C CG2 . THR B 1 91  ? -29.674 7.098   11.765  1.00 16.70 ? 116 THR B CG2 1 
ATOM   2696 N N   . MET B 1 92  ? -26.570 7.359   8.826   1.00 16.08 ? 117 MET B N   1 
ATOM   2697 C CA  . MET B 1 92  ? -25.269 7.367   8.192   1.00 12.36 ? 117 MET B CA  1 
ATOM   2698 C C   . MET B 1 92  ? -24.486 8.322   9.071   1.00 11.76 ? 117 MET B C   1 
ATOM   2699 O O   . MET B 1 92  ? -25.039 9.333   9.505   1.00 13.17 ? 117 MET B O   1 
ATOM   2700 C CB  . MET B 1 92  ? -25.549 7.957   6.811   1.00 17.64 ? 117 MET B CB  1 
ATOM   2701 C CG  . MET B 1 92  ? -25.860 6.911   5.739   1.00 12.48 ? 117 MET B CG  1 
ATOM   2702 S SD  . MET B 1 92  ? -25.659 7.542   4.077   1.00 14.10 ? 117 MET B SD  1 
ATOM   2703 C CE  . MET B 1 92  ? -23.880 7.750   4.015   1.00 15.84 ? 117 MET B CE  1 
ATOM   2704 N N   . THR B 1 93  ? -23.246 7.976   9.408   1.00 11.01 ? 118 THR B N   1 
ATOM   2705 C CA  . THR B 1 93  ? -22.459 8.899   10.218  1.00 9.78  ? 118 THR B CA  1 
ATOM   2706 C C   . THR B 1 93  ? -21.927 10.037  9.354   1.00 12.12 ? 118 THR B C   1 
ATOM   2707 O O   . THR B 1 93  ? -21.928 9.969   8.124   1.00 11.47 ? 118 THR B O   1 
ATOM   2708 C CB  . THR B 1 93  ? -21.294 8.199   10.906  1.00 10.33 ? 118 THR B CB  1 
ATOM   2709 O OG1 . THR B 1 93  ? -20.332 7.791   9.924   1.00 11.90 ? 118 THR B OG1 1 
ATOM   2710 C CG2 . THR B 1 93  ? -21.780 6.990   11.714  1.00 12.81 ? 118 THR B CG2 1 
ATOM   2711 N N   . LEU B 1 94  ? -21.458 11.094  10.018  1.00 10.59 ? 119 LEU B N   1 
ATOM   2712 C CA  . LEU B 1 94  ? -20.886 12.212  9.285   1.00 9.98  ? 119 LEU B CA  1 
ATOM   2713 C C   . LEU B 1 94  ? -19.639 11.796  8.508   1.00 10.06 ? 119 LEU B C   1 
ATOM   2714 O O   . LEU B 1 94  ? -19.408 12.297  7.403   1.00 9.97  ? 119 LEU B O   1 
ATOM   2715 C CB  . LEU B 1 94  ? -20.646 13.407  10.205  1.00 11.32 ? 119 LEU B CB  1 
ATOM   2716 C CG  . LEU B 1 94  ? -21.919 14.219  10.483  1.00 8.56  ? 119 LEU B CG  1 
ATOM   2717 C CD1 . LEU B 1 94  ? -21.705 15.189  11.632  1.00 11.84 ? 119 LEU B CD1 1 
ATOM   2718 C CD2 . LEU B 1 94  ? -22.370 14.967  9.263   1.00 11.39 ? 119 LEU B CD2 1 
ATOM   2719 N N   . ALA B 1 95  ? -18.834 10.866  9.046   1.00 8.81  ? 120 ALA B N   1 
ATOM   2720 C CA  . ALA B 1 95  ? -17.752 10.320  8.230   1.00 9.95  ? 120 ALA B CA  1 
ATOM   2721 C C   . ALA B 1 95  ? -18.295 9.590   7.005   1.00 9.71  ? 120 ALA B C   1 
ATOM   2722 O O   . ALA B 1 95  ? -17.757 9.740   5.901   1.00 11.60 ? 120 ALA B O   1 
ATOM   2723 C CB  . ALA B 1 95  ? -16.849 9.395   9.046   1.00 11.62 ? 120 ALA B CB  1 
ATOM   2724 N N   . GLU B 1 96  ? -19.346 8.784   7.182   1.00 10.60 ? 121 GLU B N   1 
ATOM   2725 C CA  . GLU B 1 96  ? -19.899 8.042   6.052   1.00 12.53 ? 121 GLU B CA  1 
ATOM   2726 C C   . GLU B 1 96  ? -20.464 8.990   5.003   1.00 10.38 ? 121 GLU B C   1 
ATOM   2727 O O   . GLU B 1 96  ? -20.317 8.763   3.797   1.00 11.93 ? 121 GLU B O   1 
ATOM   2728 C CB  . GLU B 1 96  ? -20.995 7.105   6.555   1.00 9.58  ? 121 GLU B CB  1 
ATOM   2729 C CG  . GLU B 1 96  ? -20.476 5.858   7.242   1.00 10.88 ? 121 GLU B CG  1 
ATOM   2730 C CD  . GLU B 1 96  ? -21.590 4.925   7.652   1.00 17.38 ? 121 GLU B CD  1 
ATOM   2731 O OE1 . GLU B 1 96  ? -22.419 5.332   8.493   1.00 15.59 ? 121 GLU B OE1 1 
ATOM   2732 O OE2 . GLU B 1 96  ? -21.645 3.793   7.127   1.00 17.25 ? 121 GLU B OE2 1 
ATOM   2733 N N   . LEU B 1 97  ? -21.123 10.059  5.450   1.00 10.64 ? 122 LEU B N   1 
ATOM   2734 C CA  . LEU B 1 97  ? -21.653 11.043  4.519   1.00 7.50  ? 122 LEU B CA  1 
ATOM   2735 C C   . LEU B 1 97  ? -20.529 11.772  3.790   1.00 8.34  ? 122 LEU B C   1 
ATOM   2736 O O   . LEU B 1 97  ? -20.616 12.013  2.577   1.00 9.74  ? 122 LEU B O   1 
ATOM   2737 C CB  . LEU B 1 97  ? -22.542 12.017  5.282   1.00 9.34  ? 122 LEU B CB  1 
ATOM   2738 C CG  . LEU B 1 97  ? -23.805 11.338  5.799   1.00 7.61  ? 122 LEU B CG  1 
ATOM   2739 C CD1 . LEU B 1 97  ? -24.380 12.122  6.963   1.00 10.24 ? 122 LEU B CD1 1 
ATOM   2740 C CD2 . LEU B 1 97  ? -24.803 11.240  4.660   1.00 8.17  ? 122 LEU B CD2 1 
ATOM   2741 N N   . SER B 1 98  ? -19.462 12.121  4.510   1.00 9.96  ? 123 SER B N   1 
ATOM   2742 C CA  . SER B 1 98  ? -18.311 12.770  3.886   1.00 10.49 ? 123 SER B CA  1 
ATOM   2743 C C   . SER B 1 98  ? -17.678 11.879  2.824   1.00 9.94  ? 123 SER B C   1 
ATOM   2744 O O   . SER B 1 98  ? -17.370 12.330  1.712   1.00 10.24 ? 123 SER B O   1 
ATOM   2745 C CB  . SER B 1 98  ? -17.293 13.101  4.968   1.00 8.80  ? 123 SER B CB  1 
ATOM   2746 O OG  . SER B 1 98  ? -17.801 14.052  5.874   1.00 11.59 ? 123 SER B OG  1 
ATOM   2747 N N   . ALA B 1 99  ? -17.442 10.618  3.165   1.00 8.90  ? 124 ALA B N   1 
ATOM   2748 C CA  . ALA B 1 99  ? -16.831 9.698   2.210   1.00 9.93  ? 124 ALA B CA  1 
ATOM   2749 C C   . ALA B 1 99  ? -17.739 9.475   1.011   1.00 12.51 ? 124 ALA B C   1 
ATOM   2750 O O   . ALA B 1 99  ? -17.263 9.423   -0.132  1.00 9.47  ? 124 ALA B O   1 
ATOM   2751 C CB  . ALA B 1 99  ? -16.518 8.376   2.908   1.00 11.60 ? 124 ALA B CB  1 
ATOM   2752 N N   . ALA B 1 100 ? -19.054 9.336   1.250   1.00 8.47  ? 125 ALA B N   1 
ATOM   2753 C CA  . ALA B 1 100 ? -19.976 9.137   0.139   1.00 11.05 ? 125 ALA B CA  1 
ATOM   2754 C C   . ALA B 1 100 ? -20.036 10.371  -0.752  1.00 10.49 ? 125 ALA B C   1 
ATOM   2755 O O   . ALA B 1 100 ? -20.024 10.248  -1.985  1.00 9.66  ? 125 ALA B O   1 
ATOM   2756 C CB  . ALA B 1 100 ? -21.359 8.752   0.661   1.00 8.01  ? 125 ALA B CB  1 
ATOM   2757 N N   . ALA B 1 101 ? -20.061 11.566  -0.142  1.00 8.04  ? 126 ALA B N   1 
ATOM   2758 C CA  . ALA B 1 101 ? -20.062 12.813  -0.906  1.00 9.95  ? 126 ALA B CA  1 
ATOM   2759 C C   . ALA B 1 101 ? -18.820 12.936  -1.783  1.00 8.93  ? 126 ALA B C   1 
ATOM   2760 O O   . ALA B 1 101 ? -18.916 13.300  -2.958  1.00 9.31  ? 126 ALA B O   1 
ATOM   2761 C CB  . ALA B 1 101 ? -20.170 14.013  0.030   1.00 10.23 ? 126 ALA B CB  1 
ATOM   2762 N N   . LEU B 1 102 ? -17.642 12.647  -1.227  1.00 9.42  ? 127 LEU B N   1 
ATOM   2763 C CA  . LEU B 1 102 ? -16.392 12.893  -1.947  1.00 8.54  ? 127 LEU B CA  1 
ATOM   2764 C C   . LEU B 1 102 ? -16.058 11.775  -2.937  1.00 8.98  ? 127 LEU B C   1 
ATOM   2765 O O   . LEU B 1 102 ? -15.627 12.043  -4.065  1.00 9.99  ? 127 LEU B O   1 
ATOM   2766 C CB  . LEU B 1 102 ? -15.253 13.109  -0.946  1.00 10.05 ? 127 LEU B CB  1 
ATOM   2767 C CG  . LEU B 1 102 ? -15.306 14.379  -0.092  1.00 9.19  ? 127 LEU B CG  1 
ATOM   2768 C CD1 . LEU B 1 102 ? -14.114 14.371  0.861   1.00 13.81 ? 127 LEU B CD1 1 
ATOM   2769 C CD2 . LEU B 1 102 ? -15.305 15.643  -0.965  1.00 12.83 ? 127 LEU B CD2 1 
ATOM   2770 N N   . GLN B 1 103 ? -16.257 10.522  -2.549  1.00 9.97  ? 128 GLN B N   1 
ATOM   2771 C CA  . GLN B 1 103 ? -15.716 9.431   -3.349  1.00 10.04 ? 128 GLN B CA  1 
ATOM   2772 C C   . GLN B 1 103 ? -16.713 8.850   -4.327  1.00 7.75  ? 128 GLN B C   1 
ATOM   2773 O O   . GLN B 1 103 ? -16.294 8.326   -5.362  1.00 10.60 ? 128 GLN B O   1 
ATOM   2774 C CB  . GLN B 1 103 ? -15.157 8.315   -2.461  1.00 10.25 ? 128 GLN B CB  1 
ATOM   2775 C CG  . GLN B 1 103 ? -14.168 8.794   -1.402  1.00 8.32  ? 128 GLN B CG  1 
ATOM   2776 C CD  . GLN B 1 103 ? -13.524 7.657   -0.648  1.00 11.92 ? 128 GLN B CD  1 
ATOM   2777 O OE1 . GLN B 1 103 ? -14.196 6.699   -0.235  1.00 13.96 ? 128 GLN B OE1 1 
ATOM   2778 N NE2 . GLN B 1 103 ? -12.221 7.757   -0.441  1.00 10.83 ? 128 GLN B NE2 1 
ATOM   2779 N N   . TYR B 1 104 ? -18.020 8.971   -4.044  1.00 9.39  ? 129 TYR B N   1 
ATOM   2780 C CA  . TYR B 1 104 ? -19.085 8.543   -4.942  1.00 10.08 ? 129 TYR B CA  1 
ATOM   2781 C C   . TYR B 1 104 ? -19.932 9.703   -5.434  1.00 12.10 ? 129 TYR B C   1 
ATOM   2782 O O   . TYR B 1 104 ? -20.815 9.495   -6.275  1.00 13.33 ? 129 TYR B O   1 
ATOM   2783 C CB  . TYR B 1 104 ? -19.959 7.481   -4.262  1.00 11.22 ? 129 TYR B CB  1 
ATOM   2784 C CG  . TYR B 1 104 ? -19.187 6.217   -3.973  1.00 10.86 ? 129 TYR B CG  1 
ATOM   2785 C CD1 . TYR B 1 104 ? -18.461 6.067   -2.799  1.00 12.22 ? 129 TYR B CD1 1 
ATOM   2786 C CD2 . TYR B 1 104 ? -19.185 5.169   -4.881  1.00 12.48 ? 129 TYR B CD2 1 
ATOM   2787 C CE1 . TYR B 1 104 ? -17.746 4.932   -2.547  1.00 11.93 ? 129 TYR B CE1 1 
ATOM   2788 C CE2 . TYR B 1 104 ? -18.483 4.018   -4.624  1.00 10.99 ? 129 TYR B CE2 1 
ATOM   2789 C CZ  . TYR B 1 104 ? -17.764 3.907   -3.458  1.00 11.38 ? 129 TYR B CZ  1 
ATOM   2790 O OH  . TYR B 1 104 ? -17.047 2.759   -3.191  1.00 17.74 ? 129 TYR B OH  1 
ATOM   2791 N N   . SER B 1 105 ? -19.673 10.920  -4.952  1.00 10.02 ? 130 SER B N   1 
ATOM   2792 C CA  . SER B 1 105 ? -20.403 12.121  -5.365  1.00 11.40 ? 130 SER B CA  1 
ATOM   2793 C C   . SER B 1 105 ? -21.898 11.999  -5.077  1.00 11.58 ? 130 SER B C   1 
ATOM   2794 O O   . SER B 1 105 ? -22.744 12.372  -5.897  1.00 10.38 ? 130 SER B O   1 
ATOM   2795 C CB  . SER B 1 105 ? -20.132 12.523  -6.818  1.00 10.86 ? 130 SER B CB  1 
ATOM   2796 O OG  . SER B 1 105 ? -20.212 13.939  -6.953  1.00 10.86 ? 130 SER B OG  1 
ATOM   2797 N N   . ASP B 1 106 ? -22.223 11.483  -3.895  1.00 9.12  ? 131 ASP B N   1 
ATOM   2798 C CA  . ASP B 1 106 ? -23.608 11.322  -3.471  1.00 9.35  ? 131 ASP B CA  1 
ATOM   2799 C C   . ASP B 1 106 ? -24.162 12.685  -3.067  1.00 8.60  ? 131 ASP B C   1 
ATOM   2800 O O   . ASP B 1 106 ? -23.623 13.334  -2.163  1.00 10.03 ? 131 ASP B O   1 
ATOM   2801 C CB  . ASP B 1 106 ? -23.647 10.335  -2.299  1.00 9.51  ? 131 ASP B CB  1 
ATOM   2802 C CG  . ASP B 1 106 ? -25.068 9.931   -1.911  1.00 9.75  ? 131 ASP B CG  1 
ATOM   2803 O OD1 . ASP B 1 106 ? -25.874 10.830  -1.585  1.00 9.28  ? 131 ASP B OD1 1 
ATOM   2804 O OD2 . ASP B 1 106 ? -25.385 8.717   -1.932  1.00 10.05 ? 131 ASP B OD2 1 
ATOM   2805 N N   . ASN B 1 107 ? -25.243 13.109  -3.729  1.00 8.78  ? 132 ASN B N   1 
ATOM   2806 C CA  . ASN B 1 107 ? -25.805 14.443  -3.518  1.00 7.97  ? 132 ASN B CA  1 
ATOM   2807 C C   . ASN B 1 107 ? -26.660 14.527  -2.254  1.00 10.26 ? 132 ASN B C   1 
ATOM   2808 O O   . ASN B 1 107 ? -26.766 15.613  -1.665  1.00 9.20  ? 132 ASN B O   1 
ATOM   2809 C CB  . ASN B 1 107 ? -26.658 14.845  -4.724  1.00 8.97  ? 132 ASN B CB  1 
ATOM   2810 C CG  . ASN B 1 107 ? -25.852 15.500  -5.834  1.00 10.09 ? 132 ASN B CG  1 
ATOM   2811 O OD1 . ASN B 1 107 ? -24.693 15.883  -5.648  1.00 10.88 ? 132 ASN B OD1 1 
ATOM   2812 N ND2 . ASN B 1 107 ? -26.476 15.633  -7.010  1.00 11.12 ? 132 ASN B ND2 1 
ATOM   2813 N N   . THR B 1 108 ? -27.300 13.423  -1.843  1.00 9.64  ? 133 THR B N   1 
ATOM   2814 C CA  . THR B 1 108 ? -27.983 13.432  -0.553  1.00 9.97  ? 133 THR B CA  1 
ATOM   2815 C C   . THR B 1 108 ? -26.982 13.585  0.576   1.00 7.53  ? 133 THR B C   1 
ATOM   2816 O O   . THR B 1 108 ? -27.206 14.357  1.516   1.00 9.63  ? 133 THR B O   1 
ATOM   2817 C CB  . THR B 1 108 ? -28.802 12.158  -0.361  1.00 9.19  ? 133 THR B CB  1 
ATOM   2818 O OG1 . THR B 1 108 ? -29.869 12.141  -1.311  1.00 12.84 ? 133 THR B OG1 1 
ATOM   2819 C CG2 . THR B 1 108 ? -29.392 12.098  1.038   1.00 11.19 ? 133 THR B CG2 1 
ATOM   2820 N N   . ALA B 1 109 ? -25.868 12.856  0.500   1.00 9.32  ? 134 ALA B N   1 
ATOM   2821 C CA  . ALA B 1 109 ? -24.807 13.036  1.483   1.00 9.85  ? 134 ALA B CA  1 
ATOM   2822 C C   . ALA B 1 109 ? -24.338 14.480  1.538   1.00 9.36  ? 134 ALA B C   1 
ATOM   2823 O O   . ALA B 1 109 ? -24.120 15.025  2.626   1.00 9.42  ? 134 ALA B O   1 
ATOM   2824 C CB  . ALA B 1 109 ? -23.637 12.117  1.153   1.00 10.57 ? 134 ALA B CB  1 
ATOM   2825 N N   . MET B 1 110 ? -24.172 15.123  0.379   1.00 10.01 ? 135 MET B N   1 
ATOM   2826 C CA  . MET B 1 110 ? -23.736 16.509  0.418   1.00 9.24  ? 135 MET B CA  1 
ATOM   2827 C C   . MET B 1 110 ? -24.768 17.388  1.107   1.00 9.56  ? 135 MET B C   1 
ATOM   2828 O O   . MET B 1 110 ? -24.402 18.276  1.887   1.00 10.66 ? 135 MET B O   1 
ATOM   2829 C CB  . MET B 1 110 ? -23.337 17.028  -0.973  1.00 11.39 ? 135 MET B CB  1 
ATOM   2830 C CG  . MET B 1 110 ? -23.439 18.542  -1.123  1.00 9.22  ? 135 MET B CG  1 
ATOM   2831 S SD  . MET B 1 110 ? -21.981 19.250  -0.298  1.00 10.57 ? 135 MET B SD  1 
ATOM   2832 C CE  . MET B 1 110 ? -21.690 20.740  -1.243  1.00 10.19 ? 135 MET B CE  1 
ATOM   2833 N N   . ASN B 1 111 ? -26.062 17.133  0.873   1.00 8.64  ? 136 ASN B N   1 
ATOM   2834 C CA  . ASN B 1 111 ? -27.091 17.902  1.569   1.00 8.78  ? 136 ASN B CA  1 
ATOM   2835 C C   . ASN B 1 111 ? -27.012 17.731  3.080   1.00 8.40  ? 136 ASN B C   1 
ATOM   2836 O O   . ASN B 1 111 ? -27.305 18.678  3.824   1.00 10.40 ? 136 ASN B O   1 
ATOM   2837 C CB  . ASN B 1 111 ? -28.490 17.583  1.035   1.00 7.81  ? 136 ASN B CB  1 
ATOM   2838 C CG  . ASN B 1 111 ? -28.805 18.350  -0.236  1.00 10.51 ? 136 ASN B CG  1 
ATOM   2839 O OD1 . ASN B 1 111 ? -28.024 19.214  -0.668  1.00 10.48 ? 136 ASN B OD1 1 
ATOM   2840 N ND2 . ASN B 1 111 ? -29.932 18.021  -0.860  1.00 11.54 ? 136 ASN B ND2 1 
ATOM   2841 N N   . LYS B 1 112 ? -26.626 16.547  3.565   1.00 8.41  ? 137 LYS B N   1 
ATOM   2842 C CA  . LYS B 1 112 ? -26.480 16.397  5.011   1.00 9.90  ? 137 LYS B CA  1 
ATOM   2843 C C   . LYS B 1 112 ? -25.262 17.148  5.543   1.00 9.32  ? 137 LYS B C   1 
ATOM   2844 O O   . LYS B 1 112 ? -25.308 17.671  6.662   1.00 9.99  ? 137 LYS B O   1 
ATOM   2845 C CB  . LYS B 1 112 ? -26.439 14.923  5.423   1.00 11.46 ? 137 LYS B CB  1 
ATOM   2846 C CG  . LYS B 1 112 ? -27.705 14.116  5.101   1.00 8.79  ? 137 LYS B CG  1 
ATOM   2847 C CD  . LYS B 1 112 ? -28.962 14.741  5.717   1.00 13.38 ? 137 LYS B CD  1 
ATOM   2848 C CE  . LYS B 1 112 ? -30.180 13.875  5.410   1.00 16.77 ? 137 LYS B CE  1 
ATOM   2849 N NZ  . LYS B 1 112 ? -31.415 14.348  6.103   1.00 22.67 ? 137 LYS B NZ  1 
ATOM   2850 N N   . LEU B 1 113 ? -24.177 17.229  4.769   1.00 8.91  ? 138 LEU B N   1 
ATOM   2851 C CA  . LEU B 1 113 ? -23.059 18.083  5.166   1.00 8.65  ? 138 LEU B CA  1 
ATOM   2852 C C   . LEU B 1 113 ? -23.492 19.546  5.235   1.00 8.06  ? 138 LEU B C   1 
ATOM   2853 O O   . LEU B 1 113 ? -23.194 20.246  6.210   1.00 10.15 ? 138 LEU B O   1 
ATOM   2854 C CB  . LEU B 1 113 ? -21.892 17.911  4.190   1.00 11.12 ? 138 LEU B CB  1 
ATOM   2855 C CG  . LEU B 1 113 ? -21.352 16.491  4.024   1.00 10.31 ? 138 LEU B CG  1 
ATOM   2856 C CD1 . LEU B 1 113 ? -20.250 16.442  2.975   1.00 11.81 ? 138 LEU B CD1 1 
ATOM   2857 C CD2 . LEU B 1 113 ? -20.867 15.931  5.357   1.00 11.89 ? 138 LEU B CD2 1 
ATOM   2858 N N   . ILE B 1 114 ? -24.198 20.024  4.206   1.00 10.36 ? 139 ILE B N   1 
ATOM   2859 C CA  . ILE B 1 114 ? -24.661 21.408  4.191   1.00 9.55  ? 139 ILE B CA  1 
ATOM   2860 C C   . ILE B 1 114 ? -25.548 21.682  5.397   1.00 11.12 ? 139 ILE B C   1 
ATOM   2861 O O   . ILE B 1 114 ? -25.408 22.710  6.069   1.00 10.37 ? 139 ILE B O   1 
ATOM   2862 C CB  . ILE B 1 114 ? -25.384 21.719  2.869   1.00 8.15  ? 139 ILE B CB  1 
ATOM   2863 C CG1 . ILE B 1 114 ? -24.420 21.648  1.683   1.00 9.68  ? 139 ILE B CG1 1 
ATOM   2864 C CG2 . ILE B 1 114 ? -26.037 23.082  2.941   1.00 8.26  ? 139 ILE B CG2 1 
ATOM   2865 C CD1 . ILE B 1 114 ? -25.139 21.721  0.362   1.00 9.59  ? 139 ILE B CD1 1 
ATOM   2866 N N   . ALA B 1 115 ? -26.464 20.760  5.691   1.00 10.37 ? 140 ALA B N   1 
ATOM   2867 C CA  . ALA B 1 115 ? -27.340 20.923  6.848   1.00 12.04 ? 140 ALA B CA  1 
ATOM   2868 C C   . ALA B 1 115 ? -26.549 20.969  8.157   1.00 9.65  ? 140 ALA B C   1 
ATOM   2869 O O   . ALA B 1 115 ? -26.838 21.795  9.032   1.00 12.28 ? 140 ALA B O   1 
ATOM   2870 C CB  . ALA B 1 115 ? -28.386 19.809  6.872   1.00 12.32 ? 140 ALA B CB  1 
ATOM   2871 N N   . GLN B 1 116 ? -25.538 20.105  8.305   1.00 10.89 ? 141 GLN B N   1 
ATOM   2872 C CA  . GLN B 1 116 ? -24.706 20.117  9.505   1.00 12.36 ? 141 GLN B CA  1 
ATOM   2873 C C   . GLN B 1 116 ? -24.014 21.464  9.699   1.00 11.03 ? 141 GLN B C   1 
ATOM   2874 O O   . GLN B 1 116 ? -23.725 21.853  10.836  1.00 12.60 ? 141 GLN B O   1 
ATOM   2875 C CB  . GLN B 1 116 ? -23.712 18.949  9.446   1.00 10.64 ? 141 GLN B CB  1 
ATOM   2876 C CG  . GLN B 1 116 ? -22.537 18.998  10.427  1.00 11.30 ? 141 GLN B CG  1 
ATOM   2877 C CD  . GLN B 1 116 ? -22.936 18.917  11.904  1.00 16.46 ? 141 GLN B CD  1 
ATOM   2878 O OE1 . GLN B 1 116 ? -24.006 18.410  12.260  1.00 15.25 ? 141 GLN B OE1 1 
ATOM   2879 N NE2 . GLN B 1 116 ? -22.046 19.389  12.773  1.00 13.50 ? 141 GLN B NE2 1 
ATOM   2880 N N   . LEU B 1 117 ? -23.792 22.211  8.617   1.00 9.59  ? 142 LEU B N   1 
ATOM   2881 C CA  . LEU B 1 117 ? -23.139 23.511  8.678   1.00 10.17 ? 142 LEU B CA  1 
ATOM   2882 C C   . LEU B 1 117 ? -24.139 24.663  8.731   1.00 10.01 ? 142 LEU B C   1 
ATOM   2883 O O   . LEU B 1 117 ? -23.725 25.830  8.723   1.00 12.90 ? 142 LEU B O   1 
ATOM   2884 C CB  . LEU B 1 117 ? -22.183 23.684  7.493   1.00 11.83 ? 142 LEU B CB  1 
ATOM   2885 C CG  . LEU B 1 117 ? -21.123 22.587  7.399   1.00 12.06 ? 142 LEU B CG  1 
ATOM   2886 C CD1 . LEU B 1 117 ? -20.542 22.534  5.970   1.00 10.95 ? 142 LEU B CD1 1 
ATOM   2887 C CD2 . LEU B 1 117 ? -20.056 22.825  8.432   1.00 12.70 ? 142 LEU B CD2 1 
ATOM   2888 N N   . GLY B 1 118 ? -25.431 24.358  8.801   1.00 10.16 ? 143 GLY B N   1 
ATOM   2889 C CA  . GLY B 1 118 ? -26.461 25.374  8.918   1.00 10.85 ? 143 GLY B CA  1 
ATOM   2890 C C   . GLY B 1 118 ? -26.975 25.948  7.619   1.00 14.88 ? 143 GLY B C   1 
ATOM   2891 O O   . GLY B 1 118 ? -27.622 27.000  7.645   1.00 15.74 ? 143 GLY B O   1 
ATOM   2892 N N   . GLY B 1 119 ? -26.717 25.295  6.486   1.00 12.39 ? 144 GLY B N   1 
ATOM   2893 C CA  . GLY B 1 119 ? -27.199 25.749  5.206   1.00 9.61  ? 144 GLY B CA  1 
ATOM   2894 C C   . GLY B 1 119 ? -26.047 26.164  4.314   1.00 9.86  ? 144 GLY B C   1 
ATOM   2895 O O   . GLY B 1 119 ? -24.885 26.190  4.735   1.00 9.14  ? 144 GLY B O   1 
ATOM   2896 N N   . PRO B 1 120 ? -26.346 26.494  3.064   1.00 8.60  ? 145 PRO B N   1 
ATOM   2897 C CA  . PRO B 1 120 ? -25.265 26.836  2.121   1.00 9.05  ? 145 PRO B CA  1 
ATOM   2898 C C   . PRO B 1 120 ? -24.326 27.930  2.624   1.00 9.47  ? 145 PRO B C   1 
ATOM   2899 O O   . PRO B 1 120 ? -23.100 27.833  2.448   1.00 10.50 ? 145 PRO B O   1 
ATOM   2900 C CB  . PRO B 1 120 ? -26.039 27.228  0.851   1.00 10.31 ? 145 PRO B CB  1 
ATOM   2901 C CG  . PRO B 1 120 ? -27.313 26.397  0.930   1.00 12.62 ? 145 PRO B CG  1 
ATOM   2902 C CD  . PRO B 1 120 ? -27.664 26.395  2.402   1.00 11.41 ? 145 PRO B CD  1 
ATOM   2903 N N   . GLY B 1 121 ? -24.867 28.943  3.314   1.00 8.88  ? 146 GLY B N   1 
ATOM   2904 C CA  . GLY B 1 121 ? -24.040 30.007  3.854   1.00 9.01  ? 146 GLY B CA  1 
ATOM   2905 C C   . GLY B 1 121 ? -23.045 29.549  4.900   1.00 8.04  ? 146 GLY B C   1 
ATOM   2906 O O   . GLY B 1 121 ? -22.029 30.216  5.102   1.00 11.50 ? 146 GLY B O   1 
ATOM   2907 N N   . GLY B 1 122 ? -23.316 28.429  5.573   1.00 9.46  ? 147 GLY B N   1 
ATOM   2908 C CA  . GLY B 1 122 ? -22.336 27.874  6.489   1.00 10.14 ? 147 GLY B CA  1 
ATOM   2909 C C   . GLY B 1 122 ? -21.105 27.376  5.765   1.00 11.47 ? 147 GLY B C   1 
ATOM   2910 O O   . GLY B 1 122 ? -19.992 27.423  6.304   1.00 11.81 ? 147 GLY B O   1 
ATOM   2911 N N   . VAL B 1 123 ? -21.276 26.915  4.530   1.00 11.44 ? 148 VAL B N   1 
ATOM   2912 C CA  . VAL B 1 123 ? -20.135 26.515  3.721   1.00 10.22 ? 148 VAL B CA  1 
ATOM   2913 C C   . VAL B 1 123 ? -19.340 27.745  3.302   1.00 9.44  ? 148 VAL B C   1 
ATOM   2914 O O   . VAL B 1 123 ? -18.112 27.787  3.438   1.00 11.14 ? 148 VAL B O   1 
ATOM   2915 C CB  . VAL B 1 123 ? -20.584 25.664  2.512   1.00 7.19  ? 148 VAL B CB  1 
ATOM   2916 C CG1 . VAL B 1 123 ? -19.377 25.041  1.862   1.00 11.41 ? 148 VAL B CG1 1 
ATOM   2917 C CG2 . VAL B 1 123 ? -21.566 24.575  2.948   1.00 10.83 ? 148 VAL B CG2 1 
ATOM   2918 N N   . THR B 1 124 ? -20.035 28.768  2.798   1.00 9.35  ? 149 THR B N   1 
ATOM   2919 C CA  . THR B 1 124 ? -19.376 30.017  2.441   1.00 8.99  ? 149 THR B CA  1 
ATOM   2920 C C   . THR B 1 124 ? -18.633 30.601  3.637   1.00 9.26  ? 149 THR B C   1 
ATOM   2921 O O   . THR B 1 124 ? -17.508 31.088  3.493   1.00 10.23 ? 149 THR B O   1 
ATOM   2922 C CB  . THR B 1 124 ? -20.425 31.001  1.923   1.00 9.75  ? 149 THR B CB  1 
ATOM   2923 O OG1 . THR B 1 124 ? -21.188 30.394  0.868   1.00 9.47  ? 149 THR B OG1 1 
ATOM   2924 C CG2 . THR B 1 124 ? -19.779 32.281  1.413   1.00 11.64 ? 149 THR B CG2 1 
ATOM   2925 N N   . ALA B 1 125 ? -19.242 30.549  4.826   1.00 9.78  ? 150 ALA B N   1 
ATOM   2926 C CA  . ALA B 1 125 ? -18.582 31.100  6.013   1.00 7.51  ? 150 ALA B CA  1 
ATOM   2927 C C   . ALA B 1 125 ? -17.272 30.383  6.311   1.00 11.09 ? 150 ALA B C   1 
ATOM   2928 O O   . ALA B 1 125 ? -16.273 31.020  6.667   1.00 10.87 ? 150 ALA B O   1 
ATOM   2929 C CB  . ALA B 1 125 ? -19.525 31.041  7.213   1.00 11.73 ? 150 ALA B CB  1 
ATOM   2930 N N   . PHE B 1 126 ? -17.248 29.063  6.158   1.00 9.65  ? 151 PHE B N   1 
ATOM   2931 C CA  . PHE B 1 126 ? -16.000 28.341  6.347   1.00 9.10  ? 151 PHE B CA  1 
ATOM   2932 C C   . PHE B 1 126 ? -14.961 28.799  5.337   1.00 9.63  ? 151 PHE B C   1 
ATOM   2933 O O   . PHE B 1 126 ? -13.793 29.017  5.686   1.00 10.93 ? 151 PHE B O   1 
ATOM   2934 C CB  . PHE B 1 126 ? -16.231 26.837  6.234   1.00 11.22 ? 151 PHE B CB  1 
ATOM   2935 C CG  . PHE B 1 126 ? -14.959 26.048  6.243   1.00 7.84  ? 151 PHE B CG  1 
ATOM   2936 C CD1 . PHE B 1 126 ? -14.219 25.905  7.402   1.00 11.47 ? 151 PHE B CD1 1 
ATOM   2937 C CD2 . PHE B 1 126 ? -14.473 25.484  5.075   1.00 10.16 ? 151 PHE B CD2 1 
ATOM   2938 C CE1 . PHE B 1 126 ? -13.037 25.208  7.401   1.00 14.83 ? 151 PHE B CE1 1 
ATOM   2939 C CE2 . PHE B 1 126 ? -13.294 24.764  5.078   1.00 11.83 ? 151 PHE B CE2 1 
ATOM   2940 C CZ  . PHE B 1 126 ? -12.576 24.627  6.234   1.00 13.61 ? 151 PHE B CZ  1 
ATOM   2941 N N   . ALA B 1 127 ? -15.366 28.931  4.069   1.00 8.80  ? 152 ALA B N   1 
ATOM   2942 C CA  . ALA B 1 127 ? -14.445 29.413  3.047   1.00 9.07  ? 152 ALA B CA  1 
ATOM   2943 C C   . ALA B 1 127 ? -13.832 30.740  3.457   1.00 12.24 ? 152 ALA B C   1 
ATOM   2944 O O   . ALA B 1 127 ? -12.613 30.929  3.344   1.00 9.25  ? 152 ALA B O   1 
ATOM   2945 C CB  . ALA B 1 127 ? -15.157 29.542  1.696   1.00 11.37 ? 152 ALA B CB  1 
ATOM   2946 N N   . ARG B 1 128 ? -14.658 31.653  3.989   1.00 10.65 ? 153 ARG B N   1 
ATOM   2947 C CA  . ARG B 1 128 ? -14.128 32.940  4.429   1.00 10.25 ? 153 ARG B CA  1 
ATOM   2948 C C   . ARG B 1 128 ? -13.135 32.766  5.569   1.00 10.09 ? 153 ARG B C   1 
ATOM   2949 O O   . ARG B 1 128 ? -12.110 33.463  5.622   1.00 11.47 ? 153 ARG B O   1 
ATOM   2950 C CB  . ARG B 1 128 ? -15.269 33.874  4.838   1.00 9.02  ? 153 ARG B CB  1 
ATOM   2951 C CG  . ARG B 1 128 ? -16.241 34.212  3.718   1.00 10.74 ? 153 ARG B CG  1 
ATOM   2952 C CD  . ARG B 1 128 ? -15.595 35.083  2.625   1.00 8.80  ? 153 ARG B CD  1 
ATOM   2953 N NE  . ARG B 1 128 ? -16.569 35.398  1.587   1.00 11.04 ? 153 ARG B NE  1 
ATOM   2954 C CZ  . ARG B 1 128 ? -16.875 34.585  0.584   1.00 9.63  ? 153 ARG B CZ  1 
ATOM   2955 N NH1 . ARG B 1 128 ? -16.234 33.441  0.404   1.00 9.18  ? 153 ARG B NH1 1 
ATOM   2956 N NH2 . ARG B 1 128 ? -17.840 34.931  -0.263  1.00 12.34 ? 153 ARG B NH2 1 
ATOM   2957 N N   . ALA B 1 129 ? -13.411 31.833  6.482   1.00 11.58 ? 154 ALA B N   1 
ATOM   2958 C CA  . ALA B 1 129 ? -12.544 31.667  7.642   1.00 10.62 ? 154 ALA B CA  1 
ATOM   2959 C C   . ALA B 1 129 ? -11.181 31.112  7.264   1.00 10.54 ? 154 ALA B C   1 
ATOM   2960 O O   . ALA B 1 129 ? -10.220 31.296  8.020   1.00 17.62 ? 154 ALA B O   1 
ATOM   2961 C CB  . ALA B 1 129 ? -13.224 30.778  8.687   1.00 12.05 ? 154 ALA B CB  1 
ATOM   2962 N N   . ILE B 1 130 ? -11.059 30.457  6.111   1.00 12.45 ? 155 ILE B N   1 
ATOM   2963 C CA  . ILE B 1 130 ? -9.768  29.949  5.667   1.00 14.84 ? 155 ILE B CA  1 
ATOM   2964 C C   . ILE B 1 130 ? -9.161  30.808  4.564   1.00 12.17 ? 155 ILE B C   1 
ATOM   2965 O O   . ILE B 1 130 ? -8.235  30.360  3.876   1.00 14.44 ? 155 ILE B O   1 
ATOM   2966 C CB  . ILE B 1 130 ? -9.807  28.456  5.291   1.00 16.70 ? 155 ILE B CB  1 
ATOM   2967 C CG1 . ILE B 1 130 ? -10.646 28.214  4.035   1.00 12.81 ? 155 ILE B CG1 1 
ATOM   2968 C CG2 . ILE B 1 130 ? -10.316 27.608  6.462   1.00 14.35 ? 155 ILE B CG2 1 
ATOM   2969 C CD1 . ILE B 1 130 ? -10.450 26.804  3.431   1.00 15.23 ? 155 ILE B CD1 1 
ATOM   2970 N N   . GLY B 1 131 ? -9.676  32.022  4.363   1.00 10.97 ? 156 GLY B N   1 
ATOM   2971 C CA  . GLY B 1 131 ? -9.066  32.981  3.460   1.00 10.29 ? 156 GLY B CA  1 
ATOM   2972 C C   . GLY B 1 131 ? -9.607  33.008  2.047   1.00 10.54 ? 156 GLY B C   1 
ATOM   2973 O O   . GLY B 1 131 ? -9.016  33.684  1.191   1.00 16.67 ? 156 GLY B O   1 
ATOM   2974 N N   . ASP B 1 132 ? -10.705 32.315  1.774   1.00 12.25 ? 157 ASP B N   1 
ATOM   2975 C CA  . ASP B 1 132 ? -11.297 32.294  0.445   1.00 14.80 ? 157 ASP B CA  1 
ATOM   2976 C C   . ASP B 1 132 ? -12.432 33.302  0.447   1.00 10.42 ? 157 ASP B C   1 
ATOM   2977 O O   . ASP B 1 132 ? -13.490 33.046  1.032   1.00 10.87 ? 157 ASP B O   1 
ATOM   2978 C CB  . ASP B 1 132 ? -11.815 30.896  0.124   1.00 10.91 ? 157 ASP B CB  1 
ATOM   2979 C CG  . ASP B 1 132 ? -12.181 30.730  -1.343  1.00 11.95 ? 157 ASP B CG  1 
ATOM   2980 O OD1 . ASP B 1 132 ? -12.631 31.707  -1.990  1.00 12.55 ? 157 ASP B OD1 1 
ATOM   2981 O OD2 . ASP B 1 132 ? -12.025 29.605  -1.862  1.00 13.18 ? 157 ASP B OD2 1 
ATOM   2982 N N   . GLU B 1 133 ? -12.208 34.435  -0.223  1.00 12.26 ? 158 GLU B N   1 
ATOM   2983 C CA  . GLU B 1 133 ? -13.175 35.519  -0.328  1.00 9.54  ? 158 GLU B CA  1 
ATOM   2984 C C   . GLU B 1 133 ? -14.006 35.432  -1.598  1.00 12.03 ? 158 GLU B C   1 
ATOM   2985 O O   . GLU B 1 133 ? -14.830 36.314  -1.847  1.00 15.02 ? 158 GLU B O   1 
ATOM   2986 C CB  . GLU B 1 133 ? -12.438 36.864  -0.298  1.00 17.10 ? 158 GLU B CB  1 
ATOM   2987 C CG  . GLU B 1 133 ? -11.951 37.303  1.083   1.00 15.22 ? 158 GLU B CG  1 
ATOM   2988 C CD  . GLU B 1 133 ? -13.082 37.602  2.049   1.00 21.29 ? 158 GLU B CD  1 
ATOM   2989 O OE1 . GLU B 1 133 ? -14.124 38.101  1.583   1.00 21.06 ? 158 GLU B OE1 1 
ATOM   2990 O OE2 . GLU B 1 133 ? -12.918 37.374  3.269   1.00 21.93 ? 158 GLU B OE2 1 
ATOM   2991 N N   . THR B 1 134 ? -13.843 34.365  -2.382  1.00 11.24 ? 159 THR B N   1 
ATOM   2992 C CA  . THR B 1 134 ? -14.447 34.232  -3.703  1.00 11.54 ? 159 THR B CA  1 
ATOM   2993 C C   . THR B 1 134 ? -15.551 33.184  -3.754  1.00 9.94  ? 159 THR B C   1 
ATOM   2994 O O   . THR B 1 134 ? -16.616 33.417  -4.333  1.00 10.83 ? 159 THR B O   1 
ATOM   2995 C CB  . THR B 1 134 ? -13.326 33.852  -4.685  1.00 11.08 ? 159 THR B CB  1 
ATOM   2996 O OG1 . THR B 1 134 ? -12.271 34.826  -4.602  1.00 13.15 ? 159 THR B OG1 1 
ATOM   2997 C CG2 . THR B 1 134 ? -13.840 33.736  -6.120  1.00 10.15 ? 159 THR B CG2 1 
ATOM   2998 N N   . PHE B 1 135 ? -15.288 32.009  -3.195  1.00 10.89 ? 160 PHE B N   1 
ATOM   2999 C CA  . PHE B 1 135 ? -16.241 30.909  -3.153  1.00 9.99  ? 160 PHE B CA  1 
ATOM   3000 C C   . PHE B 1 135 ? -17.588 31.387  -2.626  1.00 10.03 ? 160 PHE B C   1 
ATOM   3001 O O   . PHE B 1 135 ? -17.655 32.141  -1.657  1.00 9.64  ? 160 PHE B O   1 
ATOM   3002 C CB  . PHE B 1 135 ? -15.655 29.848  -2.208  1.00 7.51  ? 160 PHE B CB  1 
ATOM   3003 C CG  . PHE B 1 135 ? -16.578 28.699  -1.900  1.00 8.07  ? 160 PHE B CG  1 
ATOM   3004 C CD1 . PHE B 1 135 ? -17.614 28.828  -0.967  1.00 7.67  ? 160 PHE B CD1 1 
ATOM   3005 C CD2 . PHE B 1 135 ? -16.404 27.477  -2.524  1.00 11.07 ? 160 PHE B CD2 1 
ATOM   3006 C CE1 . PHE B 1 135 ? -18.465 27.764  -0.695  1.00 7.69  ? 160 PHE B CE1 1 
ATOM   3007 C CE2 . PHE B 1 135 ? -17.250 26.408  -2.241  1.00 9.80  ? 160 PHE B CE2 1 
ATOM   3008 C CZ  . PHE B 1 135 ? -18.267 26.550  -1.322  1.00 11.52 ? 160 PHE B CZ  1 
ATOM   3009 N N   . ARG B 1 136 ? -18.671 30.939  -3.258  1.00 10.05 ? 161 ARG B N   1 
ATOM   3010 C CA  . ARG B 1 136 ? -19.983 31.100  -2.642  1.00 8.67  ? 161 ARG B CA  1 
ATOM   3011 C C   . ARG B 1 136 ? -20.826 29.864  -2.898  1.00 10.15 ? 161 ARG B C   1 
ATOM   3012 O O   . ARG B 1 136 ? -20.902 29.397  -4.038  1.00 10.62 ? 161 ARG B O   1 
ATOM   3013 C CB  . ARG B 1 136 ? -20.719 32.357  -3.144  1.00 12.29 ? 161 ARG B CB  1 
ATOM   3014 C CG  . ARG B 1 136 ? -20.790 32.522  -4.668  1.00 9.81  ? 161 ARG B CG  1 
ATOM   3015 C CD  . ARG B 1 136 ? -21.368 33.864  -5.060  1.00 11.00 ? 161 ARG B CD  1 
ATOM   3016 N NE  . ARG B 1 136 ? -22.800 33.903  -4.807  1.00 11.21 ? 161 ARG B NE  1 
ATOM   3017 C CZ  . ARG B 1 136 ? -23.538 34.987  -4.971  1.00 9.52  ? 161 ARG B CZ  1 
ATOM   3018 N NH1 . ARG B 1 136 ? -23.005 36.119  -5.402  1.00 11.53 ? 161 ARG B NH1 1 
ATOM   3019 N NH2 . ARG B 1 136 ? -24.839 34.927  -4.710  1.00 9.94  ? 161 ARG B NH2 1 
ATOM   3020 N N   . LEU B 1 137 ? -21.470 29.353  -1.845  1.00 6.86  ? 162 LEU B N   1 
ATOM   3021 C CA  . LEU B 1 137 ? -22.509 28.343  -1.980  1.00 6.20  ? 162 LEU B CA  1 
ATOM   3022 C C   . LEU B 1 137 ? -23.838 28.969  -1.575  1.00 8.55  ? 162 LEU B C   1 
ATOM   3023 O O   . LEU B 1 137 ? -23.963 29.510  -0.472  1.00 10.30 ? 162 LEU B O   1 
ATOM   3024 C CB  . LEU B 1 137 ? -22.200 27.098  -1.141  1.00 8.35  ? 162 LEU B CB  1 
ATOM   3025 C CG  . LEU B 1 137 ? -22.942 25.844  -1.629  1.00 9.80  ? 162 LEU B CG  1 
ATOM   3026 C CD1 . LEU B 1 137 ? -22.412 25.422  -3.002  1.00 13.23 ? 162 LEU B CD1 1 
ATOM   3027 C CD2 . LEU B 1 137 ? -22.860 24.688  -0.619  1.00 11.93 ? 162 LEU B CD2 1 
ATOM   3028 N N   . ASP B 1 138 ? -24.814 28.892  -2.478  1.00 8.47  ? 163 ASP B N   1 
ATOM   3029 C CA  . ASP B 1 138 ? -26.097 29.564  -2.319  1.00 9.39  ? 163 ASP B CA  1 
ATOM   3030 C C   . ASP B 1 138 ? -27.283 28.618  -2.237  1.00 9.50  ? 163 ASP B C   1 
ATOM   3031 O O   . ASP B 1 138 ? -28.324 28.999  -1.680  1.00 10.08 ? 163 ASP B O   1 
ATOM   3032 C CB  . ASP B 1 138 ? -26.317 30.555  -3.476  1.00 8.75  ? 163 ASP B CB  1 
ATOM   3033 C CG  . ASP B 1 138 ? -25.213 31.599  -3.564  1.00 12.42 ? 163 ASP B CG  1 
ATOM   3034 O OD1 . ASP B 1 138 ? -25.334 32.605  -2.844  1.00 14.93 ? 163 ASP B OD1 1 
ATOM   3035 O OD2 . ASP B 1 138 ? -24.204 31.395  -4.282  1.00 9.13  ? 163 ASP B OD2 1 
ATOM   3036 N N   . ARG B 1 139 ? -27.153 27.399  -2.752  1.00 9.89  ? 164 ARG B N   1 
ATOM   3037 C CA  . ARG B 1 139 ? -28.266 26.470  -2.845  1.00 10.20 ? 164 ARG B CA  1 
ATOM   3038 C C   . ARG B 1 139 ? -27.802 25.085  -2.409  1.00 10.31 ? 164 ARG B C   1 
ATOM   3039 O O   . ARG B 1 139 ? -26.604 24.818  -2.267  1.00 11.08 ? 164 ARG B O   1 
ATOM   3040 C CB  . ARG B 1 139 ? -28.824 26.441  -4.276  1.00 9.21  ? 164 ARG B CB  1 
ATOM   3041 C CG  . ARG B 1 139 ? -29.549 27.729  -4.652  1.00 7.55  ? 164 ARG B CG  1 
ATOM   3042 C CD  . ARG B 1 139 ? -29.905 27.745  -6.134  1.00 9.01  ? 164 ARG B CD  1 
ATOM   3043 N NE  . ARG B 1 139 ? -28.692 27.831  -6.935  1.00 11.39 ? 164 ARG B NE  1 
ATOM   3044 C CZ  . ARG B 1 139 ? -28.636 27.678  -8.250  1.00 9.93  ? 164 ARG B CZ  1 
ATOM   3045 N NH1 . ARG B 1 139 ? -29.734 27.513  -8.973  1.00 10.65 ? 164 ARG B NH1 1 
ATOM   3046 N NH2 . ARG B 1 139 ? -27.445 27.662  -8.848  1.00 12.03 ? 164 ARG B NH2 1 
ATOM   3047 N N   . THR B 1 140 ? -28.778 24.209  -2.172  1.00 8.18  ? 165 THR B N   1 
ATOM   3048 C CA  . THR B 1 140 ? -28.525 22.811  -1.866  1.00 10.65 ? 165 THR B CA  1 
ATOM   3049 C C   . THR B 1 140 ? -28.515 21.995  -3.164  1.00 8.88  ? 165 THR B C   1 
ATOM   3050 O O   . THR B 1 140 ? -28.707 22.517  -4.264  1.00 9.68  ? 165 THR B O   1 
ATOM   3051 C CB  . THR B 1 140 ? -29.625 22.284  -0.938  1.00 10.63 ? 165 THR B CB  1 
ATOM   3052 O OG1 . THR B 1 140 ? -30.898 22.467  -1.582  1.00 12.98 ? 165 THR B OG1 1 
ATOM   3053 C CG2 . THR B 1 140 ? -29.636 23.043  0.357   1.00 10.40 ? 165 THR B CG2 1 
ATOM   3054 N N   . GLU B 1 141 ? -28.278 20.689  -3.034  1.00 10.71 ? 166 GLU B N   1 
ATOM   3055 C CA  . GLU B 1 141 ? -28.417 19.761  -4.155  1.00 10.23 ? 166 GLU B CA  1 
ATOM   3056 C C   . GLU B 1 141 ? -29.899 19.483  -4.392  1.00 8.89  ? 166 GLU B C   1 
ATOM   3057 O O   . GLU B 1 141 ? -30.642 19.265  -3.436  1.00 11.19 ? 166 GLU B O   1 
ATOM   3058 C CB  . GLU B 1 141 ? -27.739 18.437  -3.824  1.00 9.66  ? 166 GLU B CB  1 
ATOM   3059 C CG  . GLU B 1 141 ? -26.259 18.533  -3.517  1.00 11.78 ? 166 GLU B CG  1 
ATOM   3060 C CD  . GLU B 1 141 ? -25.419 18.797  -4.765  1.00 12.75 ? 166 GLU B CD  1 
ATOM   3061 O OE1 . GLU B 1 141 ? -26.006 18.877  -5.869  1.00 12.14 ? 166 GLU B OE1 1 
ATOM   3062 O OE2 . GLU B 1 141 ? -24.177 18.907  -4.644  1.00 13.31 ? 166 GLU B OE2 1 
ATOM   3063 N N   . PRO B 1 142 ? -30.349 19.422  -5.649  1.00 9.43  ? 167 PRO B N   1 
ATOM   3064 C CA  . PRO B 1 142 ? -29.567 19.424  -6.885  1.00 11.35 ? 167 PRO B CA  1 
ATOM   3065 C C   . PRO B 1 142 ? -29.531 20.772  -7.581  1.00 9.98  ? 167 PRO B C   1 
ATOM   3066 O O   . PRO B 1 142 ? -28.883 20.908  -8.614  1.00 11.81 ? 167 PRO B O   1 
ATOM   3067 C CB  . PRO B 1 142 ? -30.338 18.409  -7.747  1.00 13.23 ? 167 PRO B CB  1 
ATOM   3068 C CG  . PRO B 1 142 ? -31.754 18.682  -7.383  1.00 13.91 ? 167 PRO B CG  1 
ATOM   3069 C CD  . PRO B 1 142 ? -31.712 18.906  -5.887  1.00 11.65 ? 167 PRO B CD  1 
ATOM   3070 N N   . THR B 1 143 ? -30.213 21.788  -7.051  1.00 8.18  ? 168 THR B N   1 
ATOM   3071 C CA  . THR B 1 143 ? -30.288 23.039  -7.794  1.00 10.18 ? 168 THR B CA  1 
ATOM   3072 C C   . THR B 1 143 ? -28.959 23.780  -7.857  1.00 9.81  ? 168 THR B C   1 
ATOM   3073 O O   . THR B 1 143 ? -28.789 24.599  -8.759  1.00 11.78 ? 168 THR B O   1 
ATOM   3074 C CB  . THR B 1 143 ? -31.424 23.954  -7.316  1.00 8.91  ? 168 THR B CB  1 
ATOM   3075 O OG1 . THR B 1 143 ? -31.176 24.416  -5.977  1.00 11.60 ? 168 THR B OG1 1 
ATOM   3076 C CG2 . THR B 1 143 ? -32.783 23.219  -7.393  1.00 8.79  ? 168 THR B CG2 1 
ATOM   3077 N N   . LEU B 1 144 ? -28.003 23.479  -6.972  1.00 8.99  ? 169 LEU B N   1 
ATOM   3078 C CA  . LEU B 1 144 ? -26.700 24.127  -7.104  1.00 9.56  ? 169 LEU B CA  1 
ATOM   3079 C C   . LEU B 1 144 ? -25.984 23.787  -8.417  1.00 9.66  ? 169 LEU B C   1 
ATOM   3080 O O   . LEU B 1 144 ? -24.972 24.423  -8.712  1.00 11.85 ? 169 LEU B O   1 
ATOM   3081 C CB  . LEU B 1 144 ? -25.804 23.898  -5.872  1.00 7.03  ? 169 LEU B CB  1 
ATOM   3082 C CG  . LEU B 1 144 ? -25.308 22.484  -5.563  1.00 8.29  ? 169 LEU B CG  1 
ATOM   3083 C CD1 . LEU B 1 144 ? -24.058 22.174  -6.371  1.00 12.53 ? 169 LEU B CD1 1 
ATOM   3084 C CD2 . LEU B 1 144 ? -24.972 22.411  -4.095  1.00 11.43 ? 169 LEU B CD2 1 
ATOM   3085 N N   . ASN B 1 145 ? -26.482 22.836  -9.213  1.00 11.14 ? 170 ASN B N   1 
ATOM   3086 C CA  . ASN B 1 145 ? -25.845 22.421  -10.459 1.00 8.36  ? 170 ASN B CA  1 
ATOM   3087 C C   . ASN B 1 145 ? -26.462 23.044  -11.717 1.00 10.59 ? 170 ASN B C   1 
ATOM   3088 O O   . ASN B 1 145 ? -26.137 22.598  -12.829 1.00 12.12 ? 170 ASN B O   1 
ATOM   3089 C CB  . ASN B 1 145 ? -25.885 20.888  -10.582 1.00 10.63 ? 170 ASN B CB  1 
ATOM   3090 C CG  . ASN B 1 145 ? -25.286 20.185  -9.373  1.00 14.22 ? 170 ASN B CG  1 
ATOM   3091 O OD1 . ASN B 1 145 ? -24.070 20.171  -9.172  1.00 12.95 ? 170 ASN B OD1 1 
ATOM   3092 N ND2 . ASN B 1 145 ? -26.155 19.600  -8.546  1.00 12.18 ? 170 ASN B ND2 1 
ATOM   3093 N N   . THR B 1 146 ? -27.349 24.041  -11.586 1.00 8.47  ? 171 THR B N   1 
ATOM   3094 C CA  . THR B 1 146 ? -28.017 24.585  -12.776 1.00 10.47 ? 171 THR B CA  1 
ATOM   3095 C C   . THR B 1 146 ? -27.029 25.210  -13.751 1.00 10.80 ? 171 THR B C   1 
ATOM   3096 O O   . THR B 1 146 ? -27.273 25.209  -14.968 1.00 13.06 ? 171 THR B O   1 
ATOM   3097 C CB  . THR B 1 146 ? -29.119 25.587  -12.415 1.00 12.17 ? 171 THR B CB  1 
ATOM   3098 O OG1 . THR B 1 146 ? -28.620 26.573  -11.497 1.00 10.85 ? 171 THR B OG1 1 
ATOM   3099 C CG2 . THR B 1 146 ? -30.324 24.879  -11.799 1.00 12.78 ? 171 THR B CG2 1 
ATOM   3100 N N   . ALA B 1 147 ? -25.940 25.785  -13.237 1.00 10.47 ? 172 ALA B N   1 
ATOM   3101 C CA  . ALA B 1 147 ? -24.781 26.179  -14.047 1.00 11.40 ? 172 ALA B CA  1 
ATOM   3102 C C   . ALA B 1 147 ? -25.127 27.188  -15.137 1.00 10.05 ? 172 ALA B C   1 
ATOM   3103 O O   . ALA B 1 147 ? -24.539 27.161  -16.217 1.00 11.84 ? 172 ALA B O   1 
ATOM   3104 C CB  . ALA B 1 147 ? -24.075 24.958  -14.652 1.00 9.14  ? 172 ALA B CB  1 
ATOM   3105 N N   . ILE B 1 148 ? -26.065 28.082  -14.864 1.00 9.59  ? 173 ILE B N   1 
ATOM   3106 C CA  . ILE B 1 148 ? -26.540 29.018  -15.895 1.00 10.19 ? 173 ILE B CA  1 
ATOM   3107 C C   . ILE B 1 148 ? -25.453 30.041  -16.200 1.00 11.65 ? 173 ILE B C   1 
ATOM   3108 O O   . ILE B 1 148 ? -24.897 30.640  -15.267 1.00 11.73 ? 173 ILE B O   1 
ATOM   3109 C CB  . ILE B 1 148 ? -27.818 29.708  -15.420 1.00 10.30 ? 173 ILE B CB  1 
ATOM   3110 C CG1 . ILE B 1 148 ? -28.931 28.672  -15.194 1.00 12.54 ? 173 ILE B CG1 1 
ATOM   3111 C CG2 . ILE B 1 148 ? -28.262 30.767  -16.431 1.00 11.88 ? 173 ILE B CG2 1 
ATOM   3112 C CD1 . ILE B 1 148 ? -30.155 29.217  -14.489 1.00 13.26 ? 173 ILE B CD1 1 
ATOM   3113 N N   . PRO B 1 149 ? -25.143 30.321  -17.469 1.00 10.54 ? 174 PRO B N   1 
ATOM   3114 C CA  . PRO B 1 149 ? -24.131 31.351  -17.756 1.00 8.77  ? 174 PRO B CA  1 
ATOM   3115 C C   . PRO B 1 149 ? -24.534 32.691  -17.157 1.00 10.64 ? 174 PRO B C   1 
ATOM   3116 O O   . PRO B 1 149 ? -25.699 33.096  -17.225 1.00 12.29 ? 174 PRO B O   1 
ATOM   3117 C CB  . PRO B 1 149 ? -24.100 31.407  -19.289 1.00 10.16 ? 174 PRO B CB  1 
ATOM   3118 C CG  . PRO B 1 149 ? -24.577 30.036  -19.719 1.00 13.80 ? 174 PRO B CG  1 
ATOM   3119 C CD  . PRO B 1 149 ? -25.626 29.653  -18.692 1.00 15.62 ? 174 PRO B CD  1 
ATOM   3120 N N   . GLY B 1 150 ? -23.560 33.360  -16.541 1.00 11.95 ? 175 GLY B N   1 
ATOM   3121 C CA  . GLY B 1 150 ? -23.775 34.661  -15.928 1.00 11.29 ? 175 GLY B CA  1 
ATOM   3122 C C   . GLY B 1 150 ? -24.359 34.626  -14.532 1.00 13.80 ? 175 GLY B C   1 
ATOM   3123 O O   . GLY B 1 150 ? -24.435 35.681  -13.883 1.00 14.12 ? 175 GLY B O   1 
ATOM   3124 N N   . ASP B 1 151 ? -24.782 33.454  -14.057 1.00 11.34 ? 176 ASP B N   1 
ATOM   3125 C CA  . ASP B 1 151 ? -25.355 33.306  -12.725 1.00 11.08 ? 176 ASP B CA  1 
ATOM   3126 C C   . ASP B 1 151 ? -24.232 33.210  -11.699 1.00 11.36 ? 176 ASP B C   1 
ATOM   3127 O O   . ASP B 1 151 ? -23.375 32.323  -11.810 1.00 11.48 ? 176 ASP B O   1 
ATOM   3128 C CB  . ASP B 1 151 ? -26.220 32.042  -12.691 1.00 10.17 ? 176 ASP B CB  1 
ATOM   3129 C CG  . ASP B 1 151 ? -27.077 31.927  -11.437 1.00 10.59 ? 176 ASP B CG  1 
ATOM   3130 O OD1 . ASP B 1 151 ? -26.918 32.680  -10.454 1.00 11.55 ? 176 ASP B OD1 1 
ATOM   3131 O OD2 . ASP B 1 151 ? -27.956 31.052  -11.446 1.00 17.05 ? 176 ASP B OD2 1 
ATOM   3132 N N   . PRO B 1 152 ? -24.180 34.100  -10.709 1.00 10.45 ? 177 PRO B N   1 
ATOM   3133 C CA  . PRO B 1 152 ? -23.120 34.017  -9.697  1.00 10.58 ? 177 PRO B CA  1 
ATOM   3134 C C   . PRO B 1 152 ? -23.345 32.950  -8.645  1.00 9.41  ? 177 PRO B C   1 
ATOM   3135 O O   . PRO B 1 152 ? -22.408 32.658  -7.886  1.00 9.91  ? 177 PRO B O   1 
ATOM   3136 C CB  . PRO B 1 152 ? -23.145 35.406  -9.046  1.00 11.92 ? 177 PRO B CB  1 
ATOM   3137 C CG  . PRO B 1 152 ? -24.486 35.938  -9.303  1.00 17.03 ? 177 PRO B CG  1 
ATOM   3138 C CD  . PRO B 1 152 ? -25.039 35.285  -10.545 1.00 12.31 ? 177 PRO B CD  1 
ATOM   3139 N N   . ARG B 1 153 ? -24.535 32.371  -8.551  1.00 9.20  ? 178 ARG B N   1 
ATOM   3140 C CA  . ARG B 1 153 ? -24.788 31.426  -7.473  1.00 8.14  ? 178 ARG B CA  1 
ATOM   3141 C C   . ARG B 1 153 ? -23.925 30.190  -7.623  1.00 10.38 ? 178 ARG B C   1 
ATOM   3142 O O   . ARG B 1 153 ? -23.739 29.674  -8.726  1.00 10.68 ? 178 ARG B O   1 
ATOM   3143 C CB  . ARG B 1 153 ? -26.265 31.033  -7.447  1.00 9.23  ? 178 ARG B CB  1 
ATOM   3144 C CG  . ARG B 1 153 ? -27.194 32.205  -7.110  1.00 9.40  ? 178 ARG B CG  1 
ATOM   3145 C CD  . ARG B 1 153 ? -28.651 31.788  -7.186  1.00 9.48  ? 178 ARG B CD  1 
ATOM   3146 N NE  . ARG B 1 153 ? -29.013 31.478  -8.564  1.00 9.93  ? 178 ARG B NE  1 
ATOM   3147 C CZ  . ARG B 1 153 ? -30.183 30.985  -8.940  1.00 10.73 ? 178 ARG B CZ  1 
ATOM   3148 N NH1 . ARG B 1 153 ? -31.174 30.822  -8.077  1.00 11.76 ? 178 ARG B NH1 1 
ATOM   3149 N NH2 . ARG B 1 153 ? -30.362 30.635  -10.212 1.00 11.17 ? 178 ARG B NH2 1 
ATOM   3150 N N   . ASP B 1 154 ? -23.361 29.738  -6.505  1.00 8.07  ? 179 ASP B N   1 
ATOM   3151 C CA  . ASP B 1 154 ? -22.669 28.457  -6.478  1.00 8.80  ? 179 ASP B CA  1 
ATOM   3152 C C   . ASP B 1 154 ? -21.462 28.464  -7.415  1.00 8.98  ? 179 ASP B C   1 
ATOM   3153 O O   . ASP B 1 154 ? -21.198 27.496  -8.137  1.00 10.60 ? 179 ASP B O   1 
ATOM   3154 C CB  . ASP B 1 154 ? -23.648 27.320  -6.784  1.00 11.10 ? 179 ASP B CB  1 
ATOM   3155 C CG  . ASP B 1 154 ? -24.885 27.394  -5.898  1.00 8.93  ? 179 ASP B CG  1 
ATOM   3156 O OD1 . ASP B 1 154 ? -24.710 27.282  -4.668  1.00 9.37  ? 179 ASP B OD1 1 
ATOM   3157 O OD2 . ASP B 1 154 ? -26.011 27.610  -6.420  1.00 10.19 ? 179 ASP B OD2 1 
ATOM   3158 N N   . THR B 1 155 ? -20.723 29.574  -7.415  1.00 8.07  ? 180 THR B N   1 
ATOM   3159 C CA  . THR B 1 155 ? -19.561 29.719  -8.277  1.00 11.78 ? 180 THR B CA  1 
ATOM   3160 C C   . THR B 1 155 ? -18.304 30.015  -7.474  1.00 10.86 ? 180 THR B C   1 
ATOM   3161 O O   . THR B 1 155 ? -18.350 30.412  -6.307  1.00 9.49  ? 180 THR B O   1 
ATOM   3162 C CB  . THR B 1 155 ? -19.731 30.845  -9.316  1.00 9.36  ? 180 THR B CB  1 
ATOM   3163 O OG1 . THR B 1 155 ? -19.925 32.104  -8.654  1.00 10.18 ? 180 THR B OG1 1 
ATOM   3164 C CG2 . THR B 1 155 ? -20.875 30.571  -10.260 1.00 9.63  ? 180 THR B CG2 1 
ATOM   3165 N N   . THR B 1 156 ? -17.169 29.832  -8.143  1.00 10.21 ? 181 THR B N   1 
ATOM   3166 C CA  . THR B 1 156 ? -15.891 30.342  -7.682  1.00 8.06  ? 181 THR B CA  1 
ATOM   3167 C C   . THR B 1 156 ? -15.019 30.606  -8.909  1.00 8.94  ? 181 THR B C   1 
ATOM   3168 O O   . THR B 1 156 ? -15.457 30.429  -10.042 1.00 9.80  ? 181 THR B O   1 
ATOM   3169 C CB  . THR B 1 156 ? -15.257 29.399  -6.647  1.00 9.04  ? 181 THR B CB  1 
ATOM   3170 O OG1 . THR B 1 156 ? -14.232 30.124  -5.941  1.00 11.64 ? 181 THR B OG1 1 
ATOM   3171 C CG2 . THR B 1 156 ? -14.661 28.137  -7.301  1.00 10.03 ? 181 THR B CG2 1 
ATOM   3172 N N   . THR B 1 157 ? -13.790 31.021  -8.681  1.00 9.29  ? 182 THR B N   1 
ATOM   3173 C CA  . THR B 1 157 ? -12.806 31.174  -9.746  1.00 9.13  ? 182 THR B CA  1 
ATOM   3174 C C   . THR B 1 157 ? -11.727 30.100  -9.636  1.00 8.59  ? 182 THR B C   1 
ATOM   3175 O O   . THR B 1 157 ? -11.478 29.556  -8.551  1.00 9.14  ? 182 THR B O   1 
ATOM   3176 C CB  . THR B 1 157 ? -12.105 32.538  -9.704  1.00 10.11 ? 182 THR B CB  1 
ATOM   3177 O OG1 . THR B 1 157 ? -11.316 32.633  -8.507  1.00 11.27 ? 182 THR B OG1 1 
ATOM   3178 C CG2 . THR B 1 157 ? -13.122 33.709  -9.765  1.00 11.72 ? 182 THR B CG2 1 
ATOM   3179 N N   . PRO B 1 158 ? -11.070 29.762  -10.749 1.00 7.36  ? 183 PRO B N   1 
ATOM   3180 C CA  . PRO B 1 158 ? -9.981  28.778  -10.665 1.00 10.03 ? 183 PRO B CA  1 
ATOM   3181 C C   . PRO B 1 158 ? -8.879  29.180  -9.699  1.00 11.11 ? 183 PRO B C   1 
ATOM   3182 O O   . PRO B 1 158 ? -8.403  28.329  -8.932  1.00 12.26 ? 183 PRO B O   1 
ATOM   3183 C CB  . PRO B 1 158 ? -9.504  28.675  -12.119 1.00 10.74 ? 183 PRO B CB  1 
ATOM   3184 C CG  . PRO B 1 158 ? -10.711 29.047  -12.942 1.00 9.65  ? 183 PRO B CG  1 
ATOM   3185 C CD  . PRO B 1 158 ? -11.370 30.143  -12.142 1.00 8.76  ? 183 PRO B CD  1 
ATOM   3186 N N   . ARG B 1 159 ? -8.487  30.460  -9.682  1.00 8.47  ? 184 ARG B N   1 
ATOM   3187 C CA  . ARG B 1 159 ? -7.410  30.890  -8.795  1.00 11.17 ? 184 ARG B CA  1 
ATOM   3188 C C   . ARG B 1 159 ? -7.786  30.668  -7.337  1.00 12.27 ? 184 ARG B C   1 
ATOM   3189 O O   . ARG B 1 159 ? -6.993  30.140  -6.545  1.00 11.40 ? 184 ARG B O   1 
ATOM   3190 C CB  . ARG B 1 159 ? -7.084  32.365  -9.052  1.00 11.72 ? 184 ARG B CB  1 
ATOM   3191 C CG  . ARG B 1 159 ? -5.903  32.859  -8.223  1.00 11.67 ? 184 ARG B CG  1 
ATOM   3192 C CD  . ARG B 1 159 ? -5.869  34.368  -8.019  1.00 13.63 ? 184 ARG B CD  1 
ATOM   3193 N NE  . ARG B 1 159 ? -5.833  35.112  -9.273  1.00 18.59 ? 184 ARG B NE  1 
ATOM   3194 C CZ  . ARG B 1 159 ? -4.713  35.484  -9.879  1.00 29.62 ? 184 ARG B CZ  1 
ATOM   3195 N NH1 . ARG B 1 159 ? -3.525  35.135  -9.406  1.00 24.58 ? 184 ARG B NH1 1 
ATOM   3196 N NH2 . ARG B 1 159 ? -4.786  36.198  -11.002 1.00 30.45 ? 184 ARG B NH2 1 
ATOM   3197 N N   . ALA B 1 160 ? -8.999  31.070  -6.956  1.00 9.89  ? 185 ALA B N   1 
ATOM   3198 C CA  . ALA B 1 160 ? -9.425  30.896  -5.576  1.00 9.27  ? 185 ALA B CA  1 
ATOM   3199 C C   . ALA B 1 160 ? -9.517  29.427  -5.192  1.00 10.92 ? 185 ALA B C   1 
ATOM   3200 O O   . ALA B 1 160 ? -9.114  29.054  -4.084  1.00 10.99 ? 185 ALA B O   1 
ATOM   3201 C CB  . ALA B 1 160 ? -10.765 31.600  -5.346  1.00 9.42  ? 185 ALA B CB  1 
ATOM   3202 N N   . MET B 1 161 ? -10.065 28.579  -6.072  1.00 8.83  ? 186 MET B N   1 
ATOM   3203 C CA  . MET B 1 161 ? -10.277 27.190  -5.673  1.00 10.00 ? 186 MET B CA  1 
ATOM   3204 C C   . MET B 1 161 ? -8.933  26.471  -5.563  1.00 10.62 ? 186 MET B C   1 
ATOM   3205 O O   . MET B 1 161 ? -8.743  25.622  -4.684  1.00 10.97 ? 186 MET B O   1 
ATOM   3206 C CB  . MET B 1 161 ? -11.164 26.484  -6.710  1.00 8.97  ? 186 MET B CB  1 
ATOM   3207 C CG  . MET B 1 161 ? -11.773 25.144  -6.267  1.00 12.23 ? 186 MET B CG  1 
ATOM   3208 S SD  . MET B 1 161 ? -12.523 25.164  -4.593  1.00 12.17 ? 186 MET B SD  1 
ATOM   3209 C CE  . MET B 1 161 ? -14.232 24.996  -5.106  1.00 26.72 ? 186 MET B CE  1 
ATOM   3210 N N   . ALA B 1 162 ? -7.971  26.816  -6.434  1.00 9.61  ? 187 ALA B N   1 
ATOM   3211 C CA  . ALA B 1 162 ? -6.650  26.193  -6.330  1.00 9.73  ? 187 ALA B CA  1 
ATOM   3212 C C   . ALA B 1 162 ? -5.946  26.590  -5.036  1.00 9.26  ? 187 ALA B C   1 
ATOM   3213 O O   . ALA B 1 162 ? -5.332  25.743  -4.369  1.00 10.09 ? 187 ALA B O   1 
ATOM   3214 C CB  . ALA B 1 162 ? -5.788  26.544  -7.543  1.00 10.12 ? 187 ALA B CB  1 
ATOM   3215 N N   A GLN B 1 163 ? -6.036  27.868  -4.656  0.63 8.84  ? 188 GLN B N   1 
ATOM   3216 N N   B GLN B 1 163 ? -6.043  27.865  -4.649  0.37 8.90  ? 188 GLN B N   1 
ATOM   3217 C CA  A GLN B 1 163 ? -5.445  28.316  -3.396  0.63 11.27 ? 188 GLN B CA  1 
ATOM   3218 C CA  B GLN B 1 163 ? -5.427  28.297  -3.397  0.37 11.27 ? 188 GLN B CA  1 
ATOM   3219 C C   A GLN B 1 163 ? -6.075  27.593  -2.213  0.63 10.55 ? 188 GLN B C   1 
ATOM   3220 C C   B GLN B 1 163 ? -6.073  27.605  -2.202  0.37 10.57 ? 188 GLN B C   1 
ATOM   3221 O O   A GLN B 1 163 ? -5.372  27.102  -1.322  0.63 10.93 ? 188 GLN B O   1 
ATOM   3222 O O   B GLN B 1 163 ? -5.375  27.150  -1.288  0.37 10.97 ? 188 GLN B O   1 
ATOM   3223 C CB  A GLN B 1 163 ? -5.613  29.829  -3.248  0.63 11.17 ? 188 GLN B CB  1 
ATOM   3224 C CB  B GLN B 1 163 ? -5.519  29.816  -3.243  0.37 11.21 ? 188 GLN B CB  1 
ATOM   3225 C CG  A GLN B 1 163 ? -5.001  30.454  -1.986  0.63 6.87  ? 188 GLN B CG  1 
ATOM   3226 C CG  B GLN B 1 163 ? -4.824  30.624  -4.331  0.37 11.87 ? 188 GLN B CG  1 
ATOM   3227 C CD  A GLN B 1 163 ? -3.529  30.137  -1.802  0.63 15.53 ? 188 GLN B CD  1 
ATOM   3228 C CD  B GLN B 1 163 ? -3.313  30.601  -4.239  0.37 15.33 ? 188 GLN B CD  1 
ATOM   3229 O OE1 A GLN B 1 163 ? -2.793  29.959  -2.772  0.63 16.59 ? 188 GLN B OE1 1 
ATOM   3230 O OE1 B GLN B 1 163 ? -2.620  30.970  -5.191  0.37 15.29 ? 188 GLN B OE1 1 
ATOM   3231 N NE2 A GLN B 1 163 ? -3.075  30.139  -0.546  0.63 12.80 ? 188 GLN B NE2 1 
ATOM   3232 N NE2 B GLN B 1 163 ? -2.792  30.182  -3.094  0.37 17.05 ? 188 GLN B NE2 1 
ATOM   3233 N N   . THR B 1 164 ? -7.405  27.511  -2.194  1.00 10.61 ? 189 THR B N   1 
ATOM   3234 C CA  . THR B 1 164 ? -8.090  26.839  -1.099  1.00 10.44 ? 189 THR B CA  1 
ATOM   3235 C C   . THR B 1 164 ? -7.738  25.359  -1.043  1.00 10.12 ? 189 THR B C   1 
ATOM   3236 O O   . THR B 1 164 ? -7.425  24.830  0.032   1.00 11.68 ? 189 THR B O   1 
ATOM   3237 C CB  . THR B 1 164 ? -9.584  27.049  -1.262  1.00 12.97 ? 189 THR B CB  1 
ATOM   3238 O OG1 . THR B 1 164 ? -9.869  28.417  -0.948  1.00 16.02 ? 189 THR B OG1 1 
ATOM   3239 C CG2 . THR B 1 164 ? -10.357 26.115  -0.347  1.00 18.46 ? 189 THR B CG2 1 
ATOM   3240 N N   . LEU B 1 165 ? -7.713  24.687  -2.192  1.00 7.82  ? 190 LEU B N   1 
ATOM   3241 C CA  . LEU B 1 165 ? -7.387  23.266  -2.176  1.00 8.75  ? 190 LEU B CA  1 
ATOM   3242 C C   . LEU B 1 165 ? -5.977  23.043  -1.650  1.00 9.95  ? 190 LEU B C   1 
ATOM   3243 O O   . LEU B 1 165 ? -5.742  22.095  -0.894  1.00 10.67 ? 190 LEU B O   1 
ATOM   3244 C CB  . LEU B 1 165 ? -7.555  22.652  -3.566  1.00 9.64  ? 190 LEU B CB  1 
ATOM   3245 C CG  . LEU B 1 165 ? -7.483  21.128  -3.662  1.00 7.98  ? 190 LEU B CG  1 
ATOM   3246 C CD1 . LEU B 1 165 ? -8.525  20.489  -2.769  1.00 11.03 ? 190 LEU B CD1 1 
ATOM   3247 C CD2 . LEU B 1 165 ? -7.757  20.741  -5.100  1.00 10.15 ? 190 LEU B CD2 1 
ATOM   3248 N N   . ARG B 1 166 ? -5.034  23.928  -2.004  1.00 9.22  ? 191 ARG B N   1 
ATOM   3249 C CA  . ARG B 1 166 ? -3.683  23.820  -1.462  1.00 9.52  ? 191 ARG B CA  1 
ATOM   3250 C C   . ARG B 1 166 ? -3.693  23.946  0.055   1.00 10.65 ? 191 ARG B C   1 
ATOM   3251 O O   . ARG B 1 166 ? -3.134  23.100  0.763   1.00 9.83  ? 191 ARG B O   1 
ATOM   3252 C CB  . ARG B 1 166 ? -2.730  24.852  -2.074  1.00 10.75 ? 191 ARG B CB  1 
ATOM   3253 C CG  . ARG B 1 166 ? -1.347  24.776  -1.414  1.00 11.00 ? 191 ARG B CG  1 
ATOM   3254 C CD  . ARG B 1 166 ? -0.442  25.917  -1.752  1.00 17.32 ? 191 ARG B CD  1 
ATOM   3255 N NE  . ARG B 1 166 ? 0.909   25.613  -1.286  1.00 16.77 ? 191 ARG B NE  1 
ATOM   3256 C CZ  . ARG B 1 166 ? 1.984   26.325  -1.589  1.00 16.89 ? 191 ARG B CZ  1 
ATOM   3257 N NH1 . ARG B 1 166 ? 1.907   27.398  -2.361  1.00 18.88 ? 191 ARG B NH1 1 
ATOM   3258 N NH2 . ARG B 1 166 ? 3.168   25.943  -1.112  1.00 15.91 ? 191 ARG B NH2 1 
ATOM   3259 N N   . GLN B 1 167 ? -4.348  24.982  0.575   1.00 10.34 ? 192 GLN B N   1 
ATOM   3260 C CA  . GLN B 1 167 ? -4.349  25.201  2.021   1.00 11.97 ? 192 GLN B CA  1 
ATOM   3261 C C   . GLN B 1 167 ? -5.009  24.050  2.773   1.00 11.19 ? 192 GLN B C   1 
ATOM   3262 O O   . GLN B 1 167 ? -4.586  23.711  3.884   1.00 11.43 ? 192 GLN B O   1 
ATOM   3263 C CB  . GLN B 1 167 ? -5.021  26.534  2.363   1.00 10.77 ? 192 GLN B CB  1 
ATOM   3264 C CG  . GLN B 1 167 ? -4.331  27.762  1.777   1.00 11.90 ? 192 GLN B CG  1 
ATOM   3265 C CD  . GLN B 1 167 ? -2.945  28.010  2.356   1.00 19.36 ? 192 GLN B CD  1 
ATOM   3266 O OE1 . GLN B 1 167 ? -2.002  27.248  2.111   1.00 25.27 ? 192 GLN B OE1 1 
ATOM   3267 N NE2 . GLN B 1 167 ? -2.806  29.099  3.099   1.00 20.62 ? 192 GLN B NE2 1 
ATOM   3268 N N   . LEU B 1 168 ? -6.033  23.432  2.182   1.00 10.22 ? 193 LEU B N   1 
ATOM   3269 C CA  . LEU B 1 168 ? -6.772  22.359  2.840   1.00 12.60 ? 193 LEU B CA  1 
ATOM   3270 C C   . LEU B 1 168 ? -6.001  21.045  2.839   1.00 9.94  ? 193 LEU B C   1 
ATOM   3271 O O   . LEU B 1 168 ? -6.075  20.285  3.815   1.00 12.15 ? 193 LEU B O   1 
ATOM   3272 C CB  . LEU B 1 168 ? -8.120  22.152  2.146   1.00 9.84  ? 193 LEU B CB  1 
ATOM   3273 C CG  . LEU B 1 168 ? -9.220  23.194  2.358   1.00 12.60 ? 193 LEU B CG  1 
ATOM   3274 C CD1 . LEU B 1 168 ? -10.403 22.827  1.492   1.00 12.28 ? 193 LEU B CD1 1 
ATOM   3275 C CD2 . LEU B 1 168 ? -9.631  23.229  3.831   1.00 11.24 ? 193 LEU B CD2 1 
ATOM   3276 N N   . THR B 1 169 ? -5.282  20.740  1.757   1.00 9.55  ? 194 THR B N   1 
ATOM   3277 C CA  . THR B 1 169 ? -4.665  19.420  1.603   1.00 11.22 ? 194 THR B CA  1 
ATOM   3278 C C   . THR B 1 169 ? -3.168  19.400  1.857   1.00 14.18 ? 194 THR B C   1 
ATOM   3279 O O   . THR B 1 169 ? -2.626  18.344  2.188   1.00 15.71 ? 194 THR B O   1 
ATOM   3280 C CB  . THR B 1 169 ? -4.892  18.864  0.193   1.00 11.52 ? 194 THR B CB  1 
ATOM   3281 O OG1 . THR B 1 169 ? -4.289  19.744  -0.761  1.00 12.60 ? 194 THR B OG1 1 
ATOM   3282 C CG2 . THR B 1 169 ? -6.381  18.696  -0.108  1.00 12.86 ? 194 THR B CG2 1 
ATOM   3283 N N   . LEU B 1 170 ? -2.481  20.512  1.659   1.00 11.31 ? 195 LEU B N   1 
ATOM   3284 C CA  . LEU B 1 170 ? -1.042  20.570  1.839   1.00 12.17 ? 195 LEU B CA  1 
ATOM   3285 C C   . LEU B 1 170 ? -0.629  21.590  2.876   1.00 13.07 ? 195 LEU B C   1 
ATOM   3286 O O   . LEU B 1 170 ? 0.428   21.436  3.487   1.00 17.85 ? 195 LEU B O   1 
ATOM   3287 C CB  . LEU B 1 170 ? -0.365  20.913  0.503   1.00 12.41 ? 195 LEU B CB  1 
ATOM   3288 C CG  . LEU B 1 170 ? -0.638  19.947  -0.660  1.00 13.26 ? 195 LEU B CG  1 
ATOM   3289 C CD1 . LEU B 1 170 ? -0.149  20.552  -1.969  1.00 12.27 ? 195 LEU B CD1 1 
ATOM   3290 C CD2 . LEU B 1 170 ? 0.025   18.600  -0.430  1.00 15.37 ? 195 LEU B CD2 1 
ATOM   3291 N N   . GLY B 1 171 ? -1.435  22.621  3.090   1.00 11.56 ? 196 GLY B N   1 
ATOM   3292 C CA  . GLY B 1 171 ? -1.189  23.629  4.105   1.00 15.36 ? 196 GLY B CA  1 
ATOM   3293 C C   . GLY B 1 171 ? -1.866  23.302  5.419   1.00 13.26 ? 196 GLY B C   1 
ATOM   3294 O O   . GLY B 1 171 ? -2.142  22.136  5.731   1.00 15.00 ? 196 GLY B O   1 
ATOM   3295 N N   . HIS B 1 172 ? -2.168  24.348  6.192   1.00 11.08 ? 197 HIS B N   1 
ATOM   3296 C CA  . HIS B 1 172 ? -2.594  24.178  7.576   1.00 11.89 ? 197 HIS B CA  1 
ATOM   3297 C C   . HIS B 1 172 ? -3.968  24.786  7.861   1.00 16.11 ? 197 HIS B C   1 
ATOM   3298 O O   . HIS B 1 172 ? -4.236  25.235  8.979   1.00 16.72 ? 197 HIS B O   1 
ATOM   3299 C CB  . HIS B 1 172 ? -1.525  24.712  8.526   1.00 18.03 ? 197 HIS B CB  1 
ATOM   3300 C CG  . HIS B 1 172 ? -0.334  23.815  8.626   1.00 25.55 ? 197 HIS B CG  1 
ATOM   3301 N ND1 . HIS B 1 172 ? -0.291  22.720  9.464   1.00 34.43 ? 197 HIS B ND1 1 
ATOM   3302 C CD2 . HIS B 1 172 ? 0.846   23.827  7.963   1.00 28.90 ? 197 HIS B CD2 1 
ATOM   3303 C CE1 . HIS B 1 172 ? 0.871   22.107  9.323   1.00 35.97 ? 197 HIS B CE1 1 
ATOM   3304 N NE2 . HIS B 1 172 ? 1.580   22.760  8.419   1.00 32.55 ? 197 HIS B NE2 1 
ATOM   3305 N N   . ALA B 1 173 ? -4.868  24.787  6.866   1.00 12.96 ? 198 ALA B N   1 
ATOM   3306 C CA  . ALA B 1 173 ? -6.234  25.239  7.119   1.00 9.59  ? 198 ALA B CA  1 
ATOM   3307 C C   . ALA B 1 173 ? -6.990  24.258  8.011   1.00 12.13 ? 198 ALA B C   1 
ATOM   3308 O O   . ALA B 1 173 ? -7.927  24.650  8.715   1.00 12.57 ? 198 ALA B O   1 
ATOM   3309 C CB  . ALA B 1 173 ? -6.983  25.456  5.804   1.00 14.93 ? 198 ALA B CB  1 
ATOM   3310 N N   . LEU B 1 174 ? -6.598  22.992  7.993   1.00 12.94 ? 199 LEU B N   1 
ATOM   3311 C CA  . LEU B 1 174 ? -7.122  21.979  8.894   1.00 10.53 ? 199 LEU B CA  1 
ATOM   3312 C C   . LEU B 1 174 ? -6.020  21.487  9.823   1.00 12.08 ? 199 LEU B C   1 
ATOM   3313 O O   . LEU B 1 174 ? -4.826  21.630  9.543   1.00 11.94 ? 199 LEU B O   1 
ATOM   3314 C CB  . LEU B 1 174 ? -7.644  20.790  8.081   1.00 10.71 ? 199 LEU B CB  1 
ATOM   3315 C CG  . LEU B 1 174 ? -8.775  21.086  7.101   1.00 10.57 ? 199 LEU B CG  1 
ATOM   3316 C CD1 . LEU B 1 174 ? -9.097  19.829  6.318   1.00 11.93 ? 199 LEU B CD1 1 
ATOM   3317 C CD2 . LEU B 1 174 ? -9.996  21.616  7.820   1.00 12.47 ? 199 LEU B CD2 1 
ATOM   3318 N N   . GLY B 1 175 ? -6.442  20.868  10.929  1.00 12.19 ? 200 GLY B N   1 
ATOM   3319 C CA  . GLY B 1 175 ? -5.510  20.142  11.768  1.00 10.68 ? 200 GLY B CA  1 
ATOM   3320 C C   . GLY B 1 175 ? -4.865  18.997  11.013  1.00 12.95 ? 200 GLY B C   1 
ATOM   3321 O O   . GLY B 1 175 ? -5.343  18.569  9.967   1.00 13.40 ? 200 GLY B O   1 
ATOM   3322 N N   A GLU B 1 176 ? -3.767  18.480  11.568  0.55 13.09 ? 201 GLU B N   1 
ATOM   3323 N N   B GLU B 1 176 ? -3.770  18.485  11.582  0.45 13.11 ? 201 GLU B N   1 
ATOM   3324 C CA  A GLU B 1 176 ? -2.968  17.496  10.840  0.55 12.89 ? 201 GLU B CA  1 
ATOM   3325 C CA  B GLU B 1 176 ? -2.946  17.495  10.892  0.45 12.96 ? 201 GLU B CA  1 
ATOM   3326 C C   A GLU B 1 176 ? -3.760  16.227  10.547  0.55 13.57 ? 201 GLU B C   1 
ATOM   3327 C C   B GLU B 1 176 ? -3.737  16.232  10.566  0.45 13.59 ? 201 GLU B C   1 
ATOM   3328 O O   A GLU B 1 176 ? -3.703  15.689  9.433   0.55 12.41 ? 201 GLU B O   1 
ATOM   3329 O O   B GLU B 1 176 ? -3.661  15.709  9.447   0.45 12.44 ? 201 GLU B O   1 
ATOM   3330 C CB  A GLU B 1 176 ? -1.694  17.167  11.618  0.55 16.58 ? 201 GLU B CB  1 
ATOM   3331 C CB  B GLU B 1 176 ? -1.726  17.154  11.750  0.45 16.54 ? 201 GLU B CB  1 
ATOM   3332 C CG  A GLU B 1 176 ? -0.831  16.110  10.937  0.55 19.28 ? 201 GLU B CG  1 
ATOM   3333 C CG  B GLU B 1 176 ? -0.827  16.079  11.152  0.45 19.08 ? 201 GLU B CG  1 
ATOM   3334 C CD  A GLU B 1 176 ? -0.706  16.344  9.440   0.55 22.74 ? 201 GLU B CD  1 
ATOM   3335 C CD  B GLU B 1 176 ? 0.413   15.806  11.987  0.45 21.81 ? 201 GLU B CD  1 
ATOM   3336 O OE1 A GLU B 1 176 ? -0.311  17.460  9.055   0.55 28.39 ? 201 GLU B OE1 1 
ATOM   3337 O OE1 B GLU B 1 176 ? 0.370   16.013  13.218  0.45 27.34 ? 201 GLU B OE1 1 
ATOM   3338 O OE2 A GLU B 1 176 ? -1.012  15.422  8.653   0.55 27.45 ? 201 GLU B OE2 1 
ATOM   3339 O OE2 B GLU B 1 176 ? 1.433   15.380  11.406  0.45 27.00 ? 201 GLU B OE2 1 
ATOM   3340 N N   . THR B 1 177 ? -4.480  15.710  11.543  1.00 12.57 ? 202 THR B N   1 
ATOM   3341 C CA  . THR B 1 177 ? -5.255  14.496  11.307  1.00 11.66 ? 202 THR B CA  1 
ATOM   3342 C C   . THR B 1 177 ? -6.387  14.750  10.312  1.00 11.01 ? 202 THR B C   1 
ATOM   3343 O O   . THR B 1 177 ? -6.679  13.898  9.460   1.00 14.86 ? 202 THR B O   1 
ATOM   3344 C CB  . THR B 1 177 ? -5.770  13.910  12.623  1.00 16.63 ? 202 THR B CB  1 
ATOM   3345 O OG1 . THR B 1 177 ? -6.472  14.910  13.356  1.00 23.69 ? 202 THR B OG1 1 
ATOM   3346 C CG2 . THR B 1 177 ? -4.602  13.429  13.478  1.00 17.86 ? 202 THR B CG2 1 
ATOM   3347 N N   . GLN B 1 178 ? -7.017  15.923  10.381  1.00 12.72 ? 203 GLN B N   1 
ATOM   3348 C CA  . GLN B 1 178 ? -8.104  16.225  9.458   1.00 11.67 ? 203 GLN B CA  1 
ATOM   3349 C C   . GLN B 1 178 ? -7.585  16.399  8.034   1.00 12.96 ? 203 GLN B C   1 
ATOM   3350 O O   . GLN B 1 178 ? -8.219  15.940  7.079   1.00 10.52 ? 203 GLN B O   1 
ATOM   3351 C CB  . GLN B 1 178 ? -8.843  17.473  9.938   1.00 10.99 ? 203 GLN B CB  1 
ATOM   3352 C CG  . GLN B 1 178 ? -9.655  17.251  11.221  1.00 10.62 ? 203 GLN B CG  1 
ATOM   3353 C CD  . GLN B 1 178 ? -8.800  17.180  12.487  1.00 11.47 ? 203 GLN B CD  1 
ATOM   3354 O OE1 . GLN B 1 178 ? -7.744  17.810  12.582  1.00 13.62 ? 203 GLN B OE1 1 
ATOM   3355 N NE2 . GLN B 1 178 ? -9.275  16.428  13.471  1.00 14.71 ? 203 GLN B NE2 1 
ATOM   3356 N N   . ARG B 1 179 ? -6.443  17.070  7.872   1.00 12.65 ? 204 ARG B N   1 
ATOM   3357 C CA  . ARG B 1 179 ? -5.827  17.193  6.553   1.00 11.55 ? 204 ARG B CA  1 
ATOM   3358 C C   . ARG B 1 179 ? -5.543  15.817  5.964   1.00 11.95 ? 204 ARG B C   1 
ATOM   3359 O O   . ARG B 1 179 ? -5.859  15.544  4.803   1.00 10.81 ? 204 ARG B O   1 
ATOM   3360 C CB  . ARG B 1 179 ? -4.547  18.017  6.659   1.00 13.09 ? 204 ARG B CB  1 
ATOM   3361 C CG  . ARG B 1 179 ? -3.678  18.014  5.412   1.00 15.69 ? 204 ARG B CG  1 
ATOM   3362 C CD  . ARG B 1 179 ? -2.446  18.897  5.582   1.00 15.12 ? 204 ARG B CD  1 
ATOM   3363 N NE  . ARG B 1 179 ? -1.364  18.255  6.321   1.00 24.70 ? 204 ARG B NE  1 
ATOM   3364 C CZ  . ARG B 1 179 ? -0.178  18.814  6.539   1.00 26.72 ? 204 ARG B CZ  1 
ATOM   3365 N NH1 . ARG B 1 179 ? 0.106   20.031  6.103   1.00 26.21 ? 204 ARG B NH1 1 
ATOM   3366 N NH2 . ARG B 1 179 ? 0.745   18.136  7.221   1.00 22.60 ? 204 ARG B NH2 1 
ATOM   3367 N N   . ALA B 1 180 ? -4.960  14.928  6.768   1.00 11.50 ? 205 ALA B N   1 
ATOM   3368 C CA  . ALA B 1 180 ? -4.676  13.574  6.306   1.00 11.82 ? 205 ALA B CA  1 
ATOM   3369 C C   . ALA B 1 180 ? -5.952  12.833  5.922   1.00 11.68 ? 205 ALA B C   1 
ATOM   3370 O O   . ALA B 1 180 ? -5.970  12.111  4.919   1.00 10.46 ? 205 ALA B O   1 
ATOM   3371 C CB  . ALA B 1 180 ? -3.866  12.817  7.363   1.00 12.32 ? 205 ALA B CB  1 
ATOM   3372 N N   . GLN B 1 181 ? -7.033  13.006  6.699   1.00 9.90  ? 206 GLN B N   1 
ATOM   3373 C CA  . GLN B 1 181 ? -8.308  12.379  6.350   1.00 9.32  ? 206 GLN B CA  1 
ATOM   3374 C C   . GLN B 1 181 ? -8.840  12.896  5.013   1.00 10.08 ? 206 GLN B C   1 
ATOM   3375 O O   . GLN B 1 181 ? -9.336  12.117  4.187   1.00 11.44 ? 206 GLN B O   1 
ATOM   3376 C CB  . GLN B 1 181 ? -9.338  12.606  7.464   1.00 9.95  ? 206 GLN B CB  1 
ATOM   3377 C CG  . GLN B 1 181 ? -10.732 12.012  7.199   1.00 11.56 ? 206 GLN B CG  1 
ATOM   3378 C CD  . GLN B 1 181 ? -10.720 10.505  7.081   1.00 12.41 ? 206 GLN B CD  1 
ATOM   3379 O OE1 . GLN B 1 181 ? -10.863 9.798   8.073   1.00 17.69 ? 206 GLN B OE1 1 
ATOM   3380 N NE2 . GLN B 1 181 ? -10.547 10.006  5.870   1.00 11.93 ? 206 GLN B NE2 1 
ATOM   3381 N N   . LEU B 1 182 ? -8.746  14.203  4.779   1.00 10.29 ? 207 LEU B N   1 
ATOM   3382 C CA  . LEU B 1 182 ? -9.228  14.764  3.524   1.00 9.12  ? 207 LEU B CA  1 
ATOM   3383 C C   . LEU B 1 182 ? -8.435  14.219  2.350   1.00 9.25  ? 207 LEU B C   1 
ATOM   3384 O O   . LEU B 1 182 ? -9.010  13.849  1.317   1.00 10.22 ? 207 LEU B O   1 
ATOM   3385 C CB  . LEU B 1 182 ? -9.120  16.284  3.567   1.00 10.02 ? 207 LEU B CB  1 
ATOM   3386 C CG  . LEU B 1 182 ? -9.603  16.977  2.292   1.00 7.62  ? 207 LEU B CG  1 
ATOM   3387 C CD1 . LEU B 1 182 ? -11.017 16.561  1.941   1.00 12.09 ? 207 LEU B CD1 1 
ATOM   3388 C CD2 . LEU B 1 182 ? -9.510  18.493  2.462   1.00 11.69 ? 207 LEU B CD2 1 
ATOM   3389 N N   . VAL B 1 183 ? -7.109  14.140  2.503   1.00 10.96 ? 208 VAL B N   1 
ATOM   3390 C CA  . VAL B 1 183 ? -6.249  13.613  1.446   1.00 9.18  ? 208 VAL B CA  1 
ATOM   3391 C C   . VAL B 1 183 ? -6.577  12.153  1.154   1.00 10.97 ? 208 VAL B C   1 
ATOM   3392 O O   . VAL B 1 183 ? -6.701  11.757  -0.013  1.00 9.69  ? 208 VAL B O   1 
ATOM   3393 C CB  . VAL B 1 183 ? -4.767  13.827  1.815   1.00 10.77 ? 208 VAL B CB  1 
ATOM   3394 C CG1 . VAL B 1 183 ? -3.880  12.961  0.967   1.00 11.87 ? 208 VAL B CG1 1 
ATOM   3395 C CG2 . VAL B 1 183 ? -4.389  15.301  1.665   1.00 11.75 ? 208 VAL B CG2 1 
ATOM   3396 N N   . THR B 1 184 ? -6.764  11.344  2.208   1.00 11.35 ? 209 THR B N   1 
ATOM   3397 C CA  . THR B 1 184 ? -7.152  9.946   2.030   1.00 13.01 ? 209 THR B CA  1 
ATOM   3398 C C   . THR B 1 184 ? -8.458  9.836   1.256   1.00 10.56 ? 209 THR B C   1 
ATOM   3399 O O   . THR B 1 184 ? -8.590  8.993   0.355   1.00 11.47 ? 209 THR B O   1 
ATOM   3400 C CB  . THR B 1 184 ? -7.296  9.268   3.400   1.00 13.00 ? 209 THR B CB  1 
ATOM   3401 O OG1 . THR B 1 184 ? -6.036  9.236   4.085   1.00 15.78 ? 209 THR B OG1 1 
ATOM   3402 C CG2 . THR B 1 184 ? -7.812  7.835   3.254   1.00 14.38 ? 209 THR B CG2 1 
ATOM   3403 N N   . TRP B 1 185 ? -9.436  10.691  1.571   1.00 9.78  ? 210 TRP B N   1 
ATOM   3404 C CA  . TRP B 1 185 ? -10.714 10.616  0.865   1.00 9.20  ? 210 TRP B CA  1 
ATOM   3405 C C   . TRP B 1 185 ? -10.545 10.962  -0.616  1.00 10.46 ? 210 TRP B C   1 
ATOM   3406 O O   . TRP B 1 185 ? -11.048 10.252  -1.497  1.00 10.94 ? 210 TRP B O   1 
ATOM   3407 C CB  . TRP B 1 185 ? -11.743 11.546  1.510   1.00 8.57  ? 210 TRP B CB  1 
ATOM   3408 C CG  . TRP B 1 185 ? -12.433 10.992  2.764   1.00 9.91  ? 210 TRP B CG  1 
ATOM   3409 C CD1 . TRP B 1 185 ? -12.665 9.680   3.079   1.00 11.56 ? 210 TRP B CD1 1 
ATOM   3410 C CD2 . TRP B 1 185 ? -12.967 11.763  3.852   1.00 9.42  ? 210 TRP B CD2 1 
ATOM   3411 N NE1 . TRP B 1 185 ? -13.311 9.595   4.288   1.00 13.49 ? 210 TRP B NE1 1 
ATOM   3412 C CE2 . TRP B 1 185 ? -13.501 10.857  4.787   1.00 11.81 ? 210 TRP B CE2 1 
ATOM   3413 C CE3 . TRP B 1 185 ? -13.040 13.137  4.122   1.00 11.01 ? 210 TRP B CE3 1 
ATOM   3414 C CZ2 . TRP B 1 185 ? -14.106 11.273  5.972   1.00 12.70 ? 210 TRP B CZ2 1 
ATOM   3415 C CZ3 . TRP B 1 185 ? -13.637 13.553  5.300   1.00 11.27 ? 210 TRP B CZ3 1 
ATOM   3416 C CH2 . TRP B 1 185 ? -14.163 12.625  6.212   1.00 8.60  ? 210 TRP B CH2 1 
ATOM   3417 N N   . LEU B 1 186 ? -9.817  12.045  -0.907  1.00 9.58  ? 211 LEU B N   1 
ATOM   3418 C CA  . LEU B 1 186 ? -9.620  12.476  -2.291  1.00 8.54  ? 211 LEU B CA  1 
ATOM   3419 C C   . LEU B 1 186 ? -8.858  11.430  -3.094  1.00 9.56  ? 211 LEU B C   1 
ATOM   3420 O O   . LEU B 1 186 ? -9.185  11.179  -4.260  1.00 10.17 ? 211 LEU B O   1 
ATOM   3421 C CB  . LEU B 1 186 ? -8.854  13.797  -2.314  1.00 10.57 ? 211 LEU B CB  1 
ATOM   3422 C CG  . LEU B 1 186 ? -9.564  15.020  -1.747  1.00 8.83  ? 211 LEU B CG  1 
ATOM   3423 C CD1 . LEU B 1 186 ? -8.570  16.147  -1.695  1.00 12.03 ? 211 LEU B CD1 1 
ATOM   3424 C CD2 . LEU B 1 186 ? -10.724 15.376  -2.638  1.00 14.40 ? 211 LEU B CD2 1 
ATOM   3425 N N   . LYS B 1 187 ? -7.823  10.833  -2.495  1.00 11.54 ? 212 LYS B N   1 
ATOM   3426 C CA  . LYS B 1 187 ? -7.046  9.805   -3.171  1.00 9.96  ? 212 LYS B CA  1 
ATOM   3427 C C   . LYS B 1 187 ? -7.891  8.577   -3.490  1.00 9.51  ? 212 LYS B C   1 
ATOM   3428 O O   . LYS B 1 187 ? -7.587  7.859   -4.448  1.00 11.47 ? 212 LYS B O   1 
ATOM   3429 C CB  . LYS B 1 187 ? -5.830  9.432   -2.316  1.00 11.68 ? 212 LYS B CB  1 
ATOM   3430 C CG  . LYS B 1 187 ? -4.630  10.345  -2.494  1.00 13.57 ? 212 LYS B CG  1 
ATOM   3431 C CD  . LYS B 1 187 ? -3.471  9.789   -1.678  1.00 10.63 ? 212 LYS B CD  1 
ATOM   3432 C CE  . LYS B 1 187 ? -2.387  10.804  -1.476  1.00 16.35 ? 212 LYS B CE  1 
ATOM   3433 N NZ  . LYS B 1 187 ? -1.355  10.187  -0.594  1.00 22.63 ? 212 LYS B NZ  1 
ATOM   3434 N N   . GLY B 1 188 ? -8.963  8.341   -2.735  1.00 9.53  ? 213 GLY B N   1 
ATOM   3435 C CA  . GLY B 1 188 ? -9.885  7.245   -2.953  1.00 9.62  ? 213 GLY B CA  1 
ATOM   3436 C C   . GLY B 1 188 ? -11.066 7.559   -3.841  1.00 8.81  ? 213 GLY B C   1 
ATOM   3437 O O   . GLY B 1 188 ? -11.977 6.739   -3.939  1.00 9.81  ? 213 GLY B O   1 
ATOM   3438 N N   . ASN B 1 189 ? -11.087 8.717   -4.504  1.00 8.46  ? 214 ASN B N   1 
ATOM   3439 C CA  . ASN B 1 189 ? -12.182 9.031   -5.412  1.00 8.02  ? 214 ASN B CA  1 
ATOM   3440 C C   . ASN B 1 189 ? -12.374 7.937   -6.457  1.00 9.45  ? 214 ASN B C   1 
ATOM   3441 O O   . ASN B 1 189 ? -11.406 7.379   -6.975  1.00 10.14 ? 214 ASN B O   1 
ATOM   3442 C CB  . ASN B 1 189 ? -11.893 10.356  -6.121  1.00 9.73  ? 214 ASN B CB  1 
ATOM   3443 C CG  . ASN B 1 189 ? -13.038 10.777  -6.997  1.00 11.16 ? 214 ASN B CG  1 
ATOM   3444 O OD1 . ASN B 1 189 ? -14.182 10.454  -6.699  1.00 13.62 ? 214 ASN B OD1 1 
ATOM   3445 N ND2 . ASN B 1 189 ? -12.751 11.468  -8.096  1.00 10.38 ? 214 ASN B ND2 1 
ATOM   3446 N N   . THR B 1 190 ? -13.639 7.643   -6.784  1.00 10.17 ? 215 THR B N   1 
ATOM   3447 C CA  . THR B 1 190 ? -13.925 6.665   -7.827  1.00 8.35  ? 215 THR B CA  1 
ATOM   3448 C C   . THR B 1 190 ? -14.215 7.278   -9.195  1.00 10.63 ? 215 THR B C   1 
ATOM   3449 O O   . THR B 1 190 ? -14.261 6.543   -10.183 1.00 10.18 ? 215 THR B O   1 
ATOM   3450 C CB  . THR B 1 190 ? -15.110 5.777   -7.433  1.00 8.47  ? 215 THR B CB  1 
ATOM   3451 O OG1 . THR B 1 190 ? -16.322 6.544   -7.473  1.00 11.05 ? 215 THR B OG1 1 
ATOM   3452 C CG2 . THR B 1 190 ? -14.899 5.145   -6.043  1.00 11.89 ? 215 THR B CG2 1 
ATOM   3453 N N   . THR B 1 191 ? -14.403 8.590   -9.291  1.00 10.20 ? 216 THR B N   1 
ATOM   3454 C CA  . THR B 1 191 ? -15.026 9.194   -10.462 1.00 11.12 ? 216 THR B CA  1 
ATOM   3455 C C   . THR B 1 191 ? -14.059 9.936   -11.371 1.00 9.64  ? 216 THR B C   1 
ATOM   3456 O O   . THR B 1 191 ? -14.513 10.556  -12.345 1.00 10.61 ? 216 THR B O   1 
ATOM   3457 C CB  . THR B 1 191 ? -16.143 10.157  -10.047 1.00 8.63  ? 216 THR B CB  1 
ATOM   3458 O OG1 . THR B 1 191 ? -15.568 11.292  -9.386  1.00 11.33 ? 216 THR B OG1 1 
ATOM   3459 C CG2 . THR B 1 191 ? -17.164 9.463   -9.139  1.00 13.09 ? 216 THR B CG2 1 
ATOM   3460 N N   . GLY B 1 192 ? -12.755 9.881   -11.108 1.00 9.91  ? 217 GLY B N   1 
ATOM   3461 C CA  . GLY B 1 192 ? -11.883 10.872  -11.711 1.00 8.77  ? 217 GLY B CA  1 
ATOM   3462 C C   . GLY B 1 192 ? -10.939 10.443  -12.821 1.00 9.01  ? 217 GLY B C   1 
ATOM   3463 O O   . GLY B 1 192 ? -10.226 11.285  -13.370 1.00 10.06 ? 217 GLY B O   1 
ATOM   3464 N N   . ALA B 1 193 ? -10.936 9.161   -13.192 1.00 10.05 ? 218 ALA B N   1 
ATOM   3465 C CA  . ALA B 1 193 ? -9.912  8.658   -14.103 1.00 9.90  ? 218 ALA B CA  1 
ATOM   3466 C C   . ALA B 1 193 ? -10.016 9.196   -15.534 1.00 10.61 ? 218 ALA B C   1 
ATOM   3467 O O   . ALA B 1 193 ? -9.042  9.071   -16.285 1.00 13.63 ? 218 ALA B O   1 
ATOM   3468 C CB  . ALA B 1 193 ? -9.906  7.121   -14.105 1.00 13.35 ? 218 ALA B CB  1 
ATOM   3469 N N   . ALA B 1 194 ? -11.157 9.759   -15.937 1.00 10.63 ? 219 ALA B N   1 
ATOM   3470 C CA  . ALA B 1 194 ? -11.324 10.316  -17.277 1.00 11.44 ? 219 ALA B CA  1 
ATOM   3471 C C   . ALA B 1 194 ? -11.032 11.806  -17.332 1.00 10.84 ? 219 ALA B C   1 
ATOM   3472 O O   . ALA B 1 194 ? -11.055 12.385  -18.421 1.00 11.33 ? 219 ALA B O   1 
ATOM   3473 C CB  . ALA B 1 194 ? -12.742 10.041  -17.808 1.00 10.09 ? 219 ALA B CB  1 
ATOM   3474 N N   . SER B 1 195 ? -10.723 12.425  -16.203 1.00 9.08  ? 220 SER B N   1 
ATOM   3475 C CA  . SER B 1 195 ? -10.630 13.881  -16.089 1.00 10.62 ? 220 SER B CA  1 
ATOM   3476 C C   . SER B 1 195 ? -9.158  14.293  -16.003 1.00 8.66  ? 220 SER B C   1 
ATOM   3477 O O   . SER B 1 195 ? -8.384  13.886  -16.875 1.00 10.40 ? 220 SER B O   1 
ATOM   3478 C CB  . SER B 1 195 ? -11.551 14.376  -14.986 1.00 10.19 ? 220 SER B CB  1 
ATOM   3479 O OG  . SER B 1 195 ? -12.885 14.033  -15.321 1.00 9.95  ? 220 SER B OG  1 
ATOM   3480 N N   . ILE B 1 196 ? -8.745  15.103  -15.015 1.00 9.41  ? 221 ILE B N   1 
ATOM   3481 C CA  . ILE B 1 196 ? -7.344  15.533  -14.922 1.00 9.06  ? 221 ILE B CA  1 
ATOM   3482 C C   . ILE B 1 196 ? -6.384  14.349  -15.021 1.00 11.33 ? 221 ILE B C   1 
ATOM   3483 O O   . ILE B 1 196 ? -5.381  14.409  -15.743 1.00 12.07 ? 221 ILE B O   1 
ATOM   3484 C CB  . ILE B 1 196 ? -7.113  16.357  -13.639 1.00 9.75  ? 221 ILE B CB  1 
ATOM   3485 C CG1 . ILE B 1 196 ? -7.687  17.765  -13.785 1.00 10.03 ? 221 ILE B CG1 1 
ATOM   3486 C CG2 . ILE B 1 196 ? -5.610  16.397  -13.268 1.00 11.08 ? 221 ILE B CG2 1 
ATOM   3487 C CD1 . ILE B 1 196 ? -7.801  18.538  -12.459 1.00 9.80  ? 221 ILE B CD1 1 
ATOM   3488 N N   . ARG B 1 197 ? -6.693  13.254  -14.312 1.00 11.56 ? 222 ARG B N   1 
ATOM   3489 C CA  . ARG B 1 197 ? -5.800  12.097  -14.263 1.00 13.39 ? 222 ARG B CA  1 
ATOM   3490 C C   . ARG B 1 197 ? -5.492  11.551  -15.654 1.00 11.48 ? 222 ARG B C   1 
ATOM   3491 O O   . ARG B 1 197 ? -4.368  11.087  -15.901 1.00 12.57 ? 222 ARG B O   1 
ATOM   3492 C CB  . ARG B 1 197 ? -6.422  11.011  -13.384 1.00 12.12 ? 222 ARG B CB  1 
ATOM   3493 C CG  . ARG B 1 197 ? -5.803  9.625   -13.529 1.00 15.90 ? 222 ARG B CG  1 
ATOM   3494 C CD  . ARG B 1 197 ? -6.077  8.783   -12.286 1.00 27.20 ? 222 ARG B CD  1 
ATOM   3495 N NE  . ARG B 1 197 ? -5.346  7.519   -12.282 1.00 27.52 ? 222 ARG B NE  1 
ATOM   3496 C CZ  . ARG B 1 197 ? -5.431  6.606   -11.323 1.00 19.77 ? 222 ARG B CZ  1 
ATOM   3497 N NH1 . ARG B 1 197 ? -6.146  6.817   -10.228 1.00 26.24 ? 222 ARG B NH1 1 
ATOM   3498 N NH2 . ARG B 1 197 ? -4.773  5.454   -11.459 1.00 21.54 ? 222 ARG B NH2 1 
ATOM   3499 N N   . ALA B 1 198 ? -6.455  11.620  -16.571 1.00 11.80 ? 223 ALA B N   1 
ATOM   3500 C CA  . ALA B 1 198 ? -6.282  11.064  -17.911 1.00 12.84 ? 223 ALA B CA  1 
ATOM   3501 C C   . ALA B 1 198 ? -5.236  11.816  -18.718 1.00 13.51 ? 223 ALA B C   1 
ATOM   3502 O O   . ALA B 1 198 ? -4.727  11.273  -19.704 1.00 15.01 ? 223 ALA B O   1 
ATOM   3503 C CB  . ALA B 1 198 ? -7.612  11.066  -18.668 1.00 11.61 ? 223 ALA B CB  1 
ATOM   3504 N N   . GLY B 1 199 ? -4.909  13.047  -18.337 1.00 11.96 ? 224 GLY B N   1 
ATOM   3505 C CA  . GLY B 1 199 ? -3.899  13.806  -19.035 1.00 10.78 ? 224 GLY B CA  1 
ATOM   3506 C C   . GLY B 1 199 ? -2.514  13.746  -18.436 1.00 13.70 ? 224 GLY B C   1 
ATOM   3507 O O   . GLY B 1 199 ? -1.604  14.384  -18.971 1.00 15.37 ? 224 GLY B O   1 
ATOM   3508 N N   . LEU B 1 200 ? -2.322  12.999  -17.349 1.00 13.93 ? 225 LEU B N   1 
ATOM   3509 C CA  . LEU B 1 200 ? -1.081  12.923  -16.597 1.00 18.57 ? 225 LEU B CA  1 
ATOM   3510 C C   . LEU B 1 200 ? -0.387  11.580  -16.793 1.00 12.21 ? 225 LEU B C   1 
ATOM   3511 O O   . LEU B 1 200 ? -1.027  10.573  -17.118 1.00 14.70 ? 225 LEU B O   1 
ATOM   3512 C CB  . LEU B 1 200 ? -1.383  13.099  -15.104 1.00 13.61 ? 225 LEU B CB  1 
ATOM   3513 C CG  . LEU B 1 200 ? -2.056  14.420  -14.713 1.00 14.25 ? 225 LEU B CG  1 
ATOM   3514 C CD1 . LEU B 1 200 ? -2.312  14.475  -13.220 1.00 13.67 ? 225 LEU B CD1 1 
ATOM   3515 C CD2 . LEU B 1 200 ? -1.237  15.622  -15.177 1.00 17.49 ? 225 LEU B CD2 1 
ATOM   3516 N N   . PRO B 1 201 ? 0.930   11.524  -16.595 1.00 14.01 ? 226 PRO B N   1 
ATOM   3517 C CA  . PRO B 1 201 ? 1.611   10.226  -16.632 1.00 16.60 ? 226 PRO B CA  1 
ATOM   3518 C C   . PRO B 1 201 ? 1.086   9.320   -15.530 1.00 17.80 ? 226 PRO B C   1 
ATOM   3519 O O   . PRO B 1 201 ? 0.728   9.773   -14.441 1.00 16.96 ? 226 PRO B O   1 
ATOM   3520 C CB  . PRO B 1 201 ? 3.086   10.586  -16.404 1.00 17.21 ? 226 PRO B CB  1 
ATOM   3521 C CG  . PRO B 1 201 ? 3.204   12.044  -16.756 1.00 16.76 ? 226 PRO B CG  1 
ATOM   3522 C CD  . PRO B 1 201 ? 1.864   12.652  -16.402 1.00 18.33 ? 226 PRO B CD  1 
ATOM   3523 N N   . THR B 1 202 ? 1.056   8.016   -15.813 1.00 17.73 ? 227 THR B N   1 
ATOM   3524 C CA  . THR B 1 202 ? 0.471   7.085   -14.851 1.00 18.30 ? 227 THR B CA  1 
ATOM   3525 C C   . THR B 1 202 ? 1.245   7.068   -13.539 1.00 22.86 ? 227 THR B C   1 
ATOM   3526 O O   . THR B 1 202 ? 0.663   6.797   -12.484 1.00 22.45 ? 227 THR B O   1 
ATOM   3527 C CB  . THR B 1 202 ? 0.392   5.677   -15.443 1.00 38.99 ? 227 THR B CB  1 
ATOM   3528 O OG1 . THR B 1 202 ? 1.715   5.170   -15.650 1.00 35.99 ? 227 THR B OG1 1 
ATOM   3529 C CG2 . THR B 1 202 ? -0.347  5.696   -16.769 1.00 30.40 ? 227 THR B CG2 1 
ATOM   3530 N N   . SER B 1 203 ? 2.544   7.374   -13.577 1.00 17.57 ? 228 SER B N   1 
ATOM   3531 C CA  . SER B 1 203 ? 3.349   7.338   -12.361 1.00 27.17 ? 228 SER B CA  1 
ATOM   3532 C C   . SER B 1 203 ? 2.939   8.412   -11.363 1.00 28.71 ? 228 SER B C   1 
ATOM   3533 O O   . SER B 1 203 ? 3.267   8.292   -10.177 1.00 31.10 ? 228 SER B O   1 
ATOM   3534 C CB  . SER B 1 203 ? 4.834   7.497   -12.696 1.00 24.43 ? 228 SER B CB  1 
ATOM   3535 O OG  . SER B 1 203 ? 5.096   8.800   -13.181 1.00 29.14 ? 228 SER B OG  1 
ATOM   3536 N N   . TRP B 1 204 ? 2.234   9.451   -11.814 1.00 17.63 ? 229 TRP B N   1 
ATOM   3537 C CA  . TRP B 1 204 ? 1.829   10.546  -10.943 1.00 19.06 ? 229 TRP B CA  1 
ATOM   3538 C C   . TRP B 1 204 ? 0.574   10.156  -10.172 1.00 23.21 ? 229 TRP B C   1 
ATOM   3539 O O   . TRP B 1 204 ? -0.397  9.673   -10.760 1.00 23.02 ? 229 TRP B O   1 
ATOM   3540 C CB  . TRP B 1 204 ? 1.540   11.809  -11.757 1.00 19.55 ? 229 TRP B CB  1 
ATOM   3541 C CG  . TRP B 1 204 ? 2.721   12.369  -12.505 1.00 17.39 ? 229 TRP B CG  1 
ATOM   3542 C CD1 . TRP B 1 204 ? 3.899   11.730  -12.794 1.00 22.64 ? 229 TRP B CD1 1 
ATOM   3543 C CD2 . TRP B 1 204 ? 2.852   13.696  -13.015 1.00 16.15 ? 229 TRP B CD2 1 
ATOM   3544 N NE1 . TRP B 1 204 ? 4.743   12.580  -13.472 1.00 21.27 ? 229 TRP B NE1 1 
ATOM   3545 C CE2 . TRP B 1 204 ? 4.122   13.791  -13.623 1.00 18.50 ? 229 TRP B CE2 1 
ATOM   3546 C CE3 . TRP B 1 204 ? 2.015   14.816  -13.025 1.00 15.81 ? 229 TRP B CE3 1 
ATOM   3547 C CZ2 . TRP B 1 204 ? 4.576   14.964  -14.234 1.00 19.13 ? 229 TRP B CZ2 1 
ATOM   3548 C CZ3 . TRP B 1 204 ? 2.461   15.976  -13.632 1.00 18.78 ? 229 TRP B CZ3 1 
ATOM   3549 C CH2 . TRP B 1 204 ? 3.737   16.044  -14.227 1.00 20.28 ? 229 TRP B CH2 1 
ATOM   3550 N N   . THR B 1 205 ? 0.589   10.384  -8.861  1.00 13.16 ? 230 THR B N   1 
ATOM   3551 C CA  . THR B 1 205 ? -0.550  10.071  -8.003  1.00 15.99 ? 230 THR B CA  1 
ATOM   3552 C C   . THR B 1 205 ? -1.485  11.272  -7.911  1.00 14.51 ? 230 THR B C   1 
ATOM   3553 O O   . THR B 1 205 ? -1.038  12.419  -7.833  1.00 13.78 ? 230 THR B O   1 
ATOM   3554 C CB  . THR B 1 205 ? -0.053  9.660   -6.610  1.00 15.18 ? 230 THR B CB  1 
ATOM   3555 O OG1 . THR B 1 205 ? 0.596   8.386   -6.704  1.00 21.84 ? 230 THR B OG1 1 
ATOM   3556 C CG2 . THR B 1 205 ? -1.190  9.534   -5.608  1.00 16.71 ? 230 THR B CG2 1 
ATOM   3557 N N   . VAL B 1 206 ? -2.790  11.000  -7.950  1.00 12.35 ? 231 VAL B N   1 
ATOM   3558 C CA  . VAL B 1 206 ? -3.817  12.036  -7.977  1.00 12.11 ? 231 VAL B CA  1 
ATOM   3559 C C   . VAL B 1 206 ? -4.875  11.769  -6.913  1.00 12.26 ? 231 VAL B C   1 
ATOM   3560 O O   . VAL B 1 206 ? -5.327  10.631  -6.734  1.00 13.41 ? 231 VAL B O   1 
ATOM   3561 C CB  . VAL B 1 206 ? -4.470  12.106  -9.369  1.00 12.22 ? 231 VAL B CB  1 
ATOM   3562 C CG1 . VAL B 1 206 ? -5.618  13.122  -9.392  1.00 13.55 ? 231 VAL B CG1 1 
ATOM   3563 C CG2 . VAL B 1 206 ? -3.428  12.494  -10.399 1.00 15.69 ? 231 VAL B CG2 1 
ATOM   3564 N N   . GLY B 1 207 ? -5.289  12.831  -6.233  1.00 9.45  ? 232 GLY B N   1 
ATOM   3565 C CA  . GLY B 1 207 ? -6.538  12.836  -5.486  1.00 10.95 ? 232 GLY B CA  1 
ATOM   3566 C C   . GLY B 1 207 ? -7.398  13.959  -6.020  1.00 10.43 ? 232 GLY B C   1 
ATOM   3567 O O   . GLY B 1 207 ? -6.890  15.064  -6.228  1.00 12.96 ? 232 GLY B O   1 
ATOM   3568 N N   . ASP B 1 208 ? -8.676  13.716  -6.298  1.00 9.91  ? 233 ASP B N   1 
ATOM   3569 C CA  . ASP B 1 208 ? -9.445  14.727  -7.011  1.00 9.43  ? 233 ASP B CA  1 
ATOM   3570 C C   . ASP B 1 208 ? -10.919 14.650  -6.637  1.00 8.51  ? 233 ASP B C   1 
ATOM   3571 O O   . ASP B 1 208 ? -11.390 13.686  -6.028  1.00 10.61 ? 233 ASP B O   1 
ATOM   3572 C CB  . ASP B 1 208 ? -9.292  14.591  -8.527  1.00 11.10 ? 233 ASP B CB  1 
ATOM   3573 C CG  . ASP B 1 208 ? -10.201 13.517  -9.101  1.00 11.84 ? 233 ASP B CG  1 
ATOM   3574 O OD1 . ASP B 1 208 ? -10.047 12.361  -8.689  1.00 10.90 ? 233 ASP B OD1 1 
ATOM   3575 O OD2 . ASP B 1 208 ? -11.059 13.823  -9.953  1.00 10.76 ? 233 ASP B OD2 1 
ATOM   3576 N N   . LYS B 1 209 ? -11.648 15.696  -7.023  1.00 8.59  ? 234 LYS B N   1 
ATOM   3577 C CA  . LYS B 1 209 ? -13.103 15.709  -6.975  1.00 6.19  ? 234 LYS B CA  1 
ATOM   3578 C C   . LYS B 1 209 ? -13.622 16.305  -8.270  1.00 8.20  ? 234 LYS B C   1 
ATOM   3579 O O   . LYS B 1 209 ? -13.269 17.438  -8.618  1.00 9.69  ? 234 LYS B O   1 
ATOM   3580 C CB  . LYS B 1 209 ? -13.608 16.536  -5.789  1.00 7.74  ? 234 LYS B CB  1 
ATOM   3581 C CG  . LYS B 1 209 ? -15.125 16.567  -5.718  1.00 8.36  ? 234 LYS B CG  1 
ATOM   3582 C CD  . LYS B 1 209 ? -15.702 15.237  -5.273  1.00 9.59  ? 234 LYS B CD  1 
ATOM   3583 C CE  . LYS B 1 209 ? -17.191 15.139  -5.518  1.00 10.57 ? 234 LYS B CE  1 
ATOM   3584 N NZ  . LYS B 1 209 ? -17.561 14.731  -6.899  1.00 9.64  ? 234 LYS B NZ  1 
ATOM   3585 N N   . THR B 1 210 ? -14.463 15.550  -8.970  1.00 9.64  ? 235 THR B N   1 
ATOM   3586 C CA  . THR B 1 210 ? -15.063 15.966  -10.227 1.00 8.55  ? 235 THR B CA  1 
ATOM   3587 C C   . THR B 1 210 ? -16.384 16.682  -9.992  1.00 11.53 ? 235 THR B C   1 
ATOM   3588 O O   . THR B 1 210 ? -16.949 16.678  -8.897  1.00 9.93  ? 235 THR B O   1 
ATOM   3589 C CB  . THR B 1 210 ? -15.345 14.752  -11.103 1.00 10.51 ? 235 THR B CB  1 
ATOM   3590 O OG1 . THR B 1 210 ? -16.015 13.758  -10.320 1.00 11.25 ? 235 THR B OG1 1 
ATOM   3591 C CG2 . THR B 1 210 ? -14.062 14.162  -11.678 1.00 11.85 ? 235 THR B CG2 1 
ATOM   3592 N N   . GLY B 1 211 ? -16.906 17.265  -11.065 1.00 8.83  ? 236 GLY B N   1 
ATOM   3593 C CA  . GLY B 1 211 ? -18.260 17.775  -11.018 1.00 11.26 ? 236 GLY B CA  1 
ATOM   3594 C C   . GLY B 1 211 ? -18.810 17.927  -12.413 1.00 10.12 ? 236 GLY B C   1 
ATOM   3595 O O   . GLY B 1 211 ? -18.066 17.967  -13.392 1.00 9.98  ? 236 GLY B O   1 
ATOM   3596 N N   . SER B 1 212 ? -20.138 17.967  -12.497 1.00 8.98  ? 237 SER B N   1 
ATOM   3597 C CA  . SER B 1 212 ? -20.790 18.211  -13.773 1.00 8.59  ? 237 SER B CA  1 
ATOM   3598 C C   . SER B 1 212 ? -22.153 18.833  -13.534 1.00 10.19 ? 237 SER B C   1 
ATOM   3599 O O   . SER B 1 212 ? -22.729 18.723  -12.454 1.00 10.98 ? 237 SER B O   1 
ATOM   3600 C CB  . SER B 1 212 ? -20.859 16.949  -14.636 1.00 12.57 ? 237 SER B CB  1 
ATOM   3601 O OG  . SER B 1 212 ? -21.571 15.916  -14.004 1.00 21.32 ? 237 SER B OG  1 
ATOM   3602 N N   . GLY B 1 213 ? -22.651 19.512  -14.557 1.00 9.86  ? 238 GLY B N   1 
ATOM   3603 C CA  . GLY B 1 213 ? -23.959 20.106  -14.431 1.00 11.79 ? 238 GLY B CA  1 
ATOM   3604 C C   . GLY B 1 213 ? -24.546 20.418  -15.787 1.00 10.73 ? 238 GLY B C   1 
ATOM   3605 O O   . GLY B 1 213 ? -24.058 19.958  -16.822 1.00 11.44 ? 238 GLY B O   1 
ATOM   3606 N N   . ASP B 1 214 ? -25.606 21.217  -15.767 1.00 9.67  ? 240 ASP B N   1 
ATOM   3607 C CA  . ASP B 1 214 ? -26.177 21.687  -17.011 1.00 8.63  ? 240 ASP B CA  1 
ATOM   3608 C C   . ASP B 1 214 ? -25.150 22.554  -17.746 1.00 9.41  ? 240 ASP B C   1 
ATOM   3609 O O   . ASP B 1 214 ? -24.080 22.884  -17.223 1.00 10.37 ? 240 ASP B O   1 
ATOM   3610 C CB  . ASP B 1 214 ? -27.450 22.491  -16.748 1.00 11.90 ? 240 ASP B CB  1 
ATOM   3611 C CG  . ASP B 1 214 ? -28.663 21.610  -16.439 1.00 16.82 ? 240 ASP B CG  1 
ATOM   3612 O OD1 . ASP B 1 214 ? -28.549 20.367  -16.500 1.00 16.79 ? 240 ASP B OD1 1 
ATOM   3613 O OD2 . ASP B 1 214 ? -29.752 22.174  -16.166 1.00 15.67 ? 240 ASP B OD2 1 
ATOM   3614 N N   . TYR B 1 215 ? -25.477 22.898  -18.993 1.00 10.20 ? 241 TYR B N   1 
ATOM   3615 C CA  . TYR B 1 215 ? -24.569 23.660  -19.855 1.00 8.66  ? 241 TYR B CA  1 
ATOM   3616 C C   . TYR B 1 215 ? -23.272 22.900  -20.126 1.00 8.96  ? 241 TYR B C   1 
ATOM   3617 O O   . TYR B 1 215 ? -22.214 23.494  -20.348 1.00 11.12 ? 241 TYR B O   1 
ATOM   3618 C CB  . TYR B 1 215 ? -24.335 25.087  -19.339 1.00 10.09 ? 241 TYR B CB  1 
ATOM   3619 C CG  . TYR B 1 215 ? -25.634 25.866  -19.418 1.00 9.84  ? 241 TYR B CG  1 
ATOM   3620 C CD1 . TYR B 1 215 ? -26.582 25.797  -18.397 1.00 10.79 ? 241 TYR B CD1 1 
ATOM   3621 C CD2 . TYR B 1 215 ? -25.952 26.597  -20.558 1.00 9.90  ? 241 TYR B CD2 1 
ATOM   3622 C CE1 . TYR B 1 215 ? -27.783 26.466  -18.492 1.00 10.96 ? 241 TYR B CE1 1 
ATOM   3623 C CE2 . TYR B 1 215 ? -27.156 27.270  -20.666 1.00 12.35 ? 241 TYR B CE2 1 
ATOM   3624 C CZ  . TYR B 1 215 ? -28.066 27.220  -19.633 1.00 12.41 ? 241 TYR B CZ  1 
ATOM   3625 O OH  . TYR B 1 215 ? -29.283 27.881  -19.756 1.00 15.52 ? 241 TYR B OH  1 
ATOM   3626 N N   . GLY B 1 216 ? -23.356 21.574  -20.142 1.00 11.14 ? 242 GLY B N   1 
ATOM   3627 C CA  . GLY B 1 216 ? -22.180 20.755  -20.391 1.00 9.77  ? 242 GLY B CA  1 
ATOM   3628 C C   . GLY B 1 216 ? -21.043 21.043  -19.442 1.00 10.34 ? 242 GLY B C   1 
ATOM   3629 O O   . GLY B 1 216 ? -19.877 20.873  -19.807 1.00 9.81  ? 242 GLY B O   1 
ATOM   3630 N N   . THR B 1 217 ? -21.357 21.497  -18.231 1.00 10.83 ? 243 THR B N   1 
ATOM   3631 C CA  . THR B 1 217 ? -20.328 21.845  -17.263 1.00 7.98  ? 243 THR B CA  1 
ATOM   3632 C C   . THR B 1 217 ? -19.588 20.595  -16.818 1.00 8.51  ? 243 THR B C   1 
ATOM   3633 O O   . THR B 1 217 ? -20.201 19.602  -16.419 1.00 11.17 ? 243 THR B O   1 
ATOM   3634 C CB  . THR B 1 217 ? -20.964 22.598  -16.094 1.00 7.97  ? 243 THR B CB  1 
ATOM   3635 O OG1 . THR B 1 217 ? -21.582 23.788  -16.623 1.00 10.26 ? 243 THR B OG1 1 
ATOM   3636 C CG2 . THR B 1 217 ? -19.912 23.014  -15.096 1.00 10.86 ? 243 THR B CG2 1 
ATOM   3637 N N   . THR B 1 218 ? -18.264 20.649  -16.910 1.00 7.56  ? 244 THR B N   1 
ATOM   3638 C CA  . THR B 1 218 ? -17.391 19.509  -16.664 1.00 8.64  ? 244 THR B CA  1 
ATOM   3639 C C   . THR B 1 218 ? -16.193 20.042  -15.898 1.00 7.37  ? 244 THR B C   1 
ATOM   3640 O O   . THR B 1 218 ? -15.440 20.858  -16.437 1.00 9.67  ? 244 THR B O   1 
ATOM   3641 C CB  . THR B 1 218 ? -16.931 18.904  -18.000 1.00 10.59 ? 244 THR B CB  1 
ATOM   3642 O OG1 . THR B 1 218 ? -18.046 18.799  -18.904 1.00 10.34 ? 244 THR B OG1 1 
ATOM   3643 C CG2 . THR B 1 218 ? -16.381 17.512  -17.784 1.00 12.86 ? 244 THR B CG2 1 
ATOM   3644 N N   . ASN B 1 219 ? -16.019 19.580  -14.651 1.00 8.12  ? 245 ASN B N   1 
ATOM   3645 C CA  . ASN B 1 219 ? -15.077 20.153  -13.705 1.00 7.78  ? 245 ASN B CA  1 
ATOM   3646 C C   . ASN B 1 219 ? -14.241 19.073  -13.023 1.00 9.07  ? 245 ASN B C   1 
ATOM   3647 O O   . ASN B 1 219 ? -14.677 17.931  -12.833 1.00 8.66  ? 245 ASN B O   1 
ATOM   3648 C CB  . ASN B 1 219 ? -15.803 20.920  -12.596 1.00 8.83  ? 245 ASN B CB  1 
ATOM   3649 C CG  . ASN B 1 219 ? -16.592 22.107  -13.104 1.00 8.05  ? 245 ASN B CG  1 
ATOM   3650 O OD1 . ASN B 1 219 ? -16.318 22.660  -14.173 1.00 8.90  ? 245 ASN B OD1 1 
ATOM   3651 N ND2 . ASN B 1 219 ? -17.591 22.514  -12.324 1.00 10.30 ? 245 ASN B ND2 1 
ATOM   3652 N N   . ASP B 1 220 ? -13.064 19.482  -12.558 1.00 9.21  ? 246 ASP B N   1 
ATOM   3653 C CA  . ASP B 1 220 ? -12.217 18.611  -11.749 1.00 8.05  ? 246 ASP B CA  1 
ATOM   3654 C C   . ASP B 1 220 ? -11.252 19.483  -10.968 1.00 8.74  ? 246 ASP B C   1 
ATOM   3655 O O   . ASP B 1 220 ? -10.702 20.448  -11.512 1.00 9.66  ? 246 ASP B O   1 
ATOM   3656 C CB  . ASP B 1 220 ? -11.444 17.625  -12.640 1.00 9.62  ? 246 ASP B CB  1 
ATOM   3657 C CG  . ASP B 1 220 ? -10.915 16.412  -11.880 1.00 9.07  ? 246 ASP B CG  1 
ATOM   3658 O OD1 . ASP B 1 220 ? -11.342 16.190  -10.729 1.00 11.39 ? 246 ASP B OD1 1 
ATOM   3659 O OD2 . ASP B 1 220 ? -10.066 15.682  -12.455 1.00 9.39  ? 246 ASP B OD2 1 
ATOM   3660 N N   . ILE B 1 221 ? -11.055 19.159  -9.690  1.00 8.43  ? 247 ILE B N   1 
ATOM   3661 C CA  . ILE B 1 221 ? -10.044 19.823  -8.873  1.00 10.35 ? 247 ILE B CA  1 
ATOM   3662 C C   . ILE B 1 221 ? -9.175  18.745  -8.243  1.00 11.12 ? 247 ILE B C   1 
ATOM   3663 O O   . ILE B 1 221 ? -9.696  17.743  -7.740  1.00 11.16 ? 247 ILE B O   1 
ATOM   3664 C CB  . ILE B 1 221 ? -10.647 20.789  -7.827  1.00 9.77  ? 247 ILE B CB  1 
ATOM   3665 C CG1 . ILE B 1 221 ? -11.413 20.059  -6.714  1.00 10.68 ? 247 ILE B CG1 1 
ATOM   3666 C CG2 . ILE B 1 221 ? -11.576 21.807  -8.508  1.00 9.80  ? 247 ILE B CG2 1 
ATOM   3667 C CD1 . ILE B 1 221 ? -11.933 21.041  -5.662  1.00 11.68 ? 247 ILE B CD1 1 
ATOM   3668 N N   . ALA B 1 222 ? -7.854  18.923  -8.314  1.00 8.65  ? 248 ALA B N   1 
ATOM   3669 C CA  . ALA B 1 222 ? -6.942  17.833  -8.000  1.00 9.33  ? 248 ALA B CA  1 
ATOM   3670 C C   . ALA B 1 222 ? -5.724  18.296  -7.217  1.00 9.98  ? 248 ALA B C   1 
ATOM   3671 O O   . ALA B 1 222 ? -5.185  19.383  -7.444  1.00 9.43  ? 248 ALA B O   1 
ATOM   3672 C CB  . ALA B 1 222 ? -6.431  17.166  -9.280  1.00 10.09 ? 248 ALA B CB  1 
ATOM   3673 N N   . VAL B 1 223 ? -5.268  17.437  -6.319  1.00 10.00 ? 249 VAL B N   1 
ATOM   3674 C CA  . VAL B 1 223 ? -3.918  17.514  -5.786  1.00 10.75 ? 249 VAL B CA  1 
ATOM   3675 C C   . VAL B 1 223 ? -3.135  16.387  -6.438  1.00 11.58 ? 249 VAL B C   1 
ATOM   3676 O O   . VAL B 1 223 ? -3.644  15.269  -6.581  1.00 11.70 ? 249 VAL B O   1 
ATOM   3677 C CB  . VAL B 1 223 ? -3.908  17.421  -4.250  1.00 11.96 ? 249 VAL B CB  1 
ATOM   3678 C CG1 . VAL B 1 223 ? -2.486  17.570  -3.701  1.00 11.60 ? 249 VAL B CG1 1 
ATOM   3679 C CG2 . VAL B 1 223 ? -4.786  18.497  -3.668  1.00 17.19 ? 249 VAL B CG2 1 
ATOM   3680 N N   . ILE B 1 224 ? -1.924  16.689  -6.893  1.00 11.87 ? 250 ILE B N   1 
ATOM   3681 C CA  . ILE B 1 224 ? -1.132  15.769  -7.701  1.00 11.36 ? 250 ILE B CA  1 
ATOM   3682 C C   . ILE B 1 224 ? 0.222   15.589  -7.036  1.00 11.95 ? 250 ILE B C   1 
ATOM   3683 O O   . ILE B 1 224 ? 0.882   16.573  -6.684  1.00 12.11 ? 250 ILE B O   1 
ATOM   3684 C CB  . ILE B 1 224 ? -0.936  16.283  -9.144  1.00 11.82 ? 250 ILE B CB  1 
ATOM   3685 C CG1 . ILE B 1 224 ? -2.276  16.469  -9.849  1.00 12.80 ? 250 ILE B CG1 1 
ATOM   3686 C CG2 . ILE B 1 224 ? -0.003  15.344  -9.923  1.00 15.68 ? 250 ILE B CG2 1 
ATOM   3687 C CD1 . ILE B 1 224 ? -2.225  17.492  -10.986 1.00 12.67 ? 250 ILE B CD1 1 
ATOM   3688 N N   . TRP B 1 225 ? 0.652   14.337  -6.885  1.00 13.48 ? 251 TRP B N   1 
ATOM   3689 C CA  . TRP B 1 225 ? 2.000   14.034  -6.414  1.00 15.26 ? 251 TRP B CA  1 
ATOM   3690 C C   . TRP B 1 225 ? 2.803   13.471  -7.583  1.00 14.42 ? 251 TRP B C   1 
ATOM   3691 O O   . TRP B 1 225 ? 2.785   12.254  -7.833  1.00 17.35 ? 251 TRP B O   1 
ATOM   3692 C CB  . TRP B 1 225 ? 1.948   13.041  -5.250  1.00 14.63 ? 251 TRP B CB  1 
ATOM   3693 C CG  . TRP B 1 225 ? 1.352   13.624  -4.005  1.00 15.85 ? 251 TRP B CG  1 
ATOM   3694 C CD1 . TRP B 1 225 ? 2.028   14.157  -2.940  1.00 16.62 ? 251 TRP B CD1 1 
ATOM   3695 C CD2 . TRP B 1 225 ? -0.045  13.746  -3.696  1.00 13.99 ? 251 TRP B CD2 1 
ATOM   3696 N NE1 . TRP B 1 225 ? 1.135   14.597  -1.989  1.00 22.16 ? 251 TRP B NE1 1 
ATOM   3697 C CE2 . TRP B 1 225 ? -0.142  14.354  -2.426  1.00 18.21 ? 251 TRP B CE2 1 
ATOM   3698 C CE3 . TRP B 1 225 ? -1.224  13.394  -4.368  1.00 15.00 ? 251 TRP B CE3 1 
ATOM   3699 C CZ2 . TRP B 1 225 ? -1.371  14.624  -1.818  1.00 17.74 ? 251 TRP B CZ2 1 
ATOM   3700 C CZ3 . TRP B 1 225 ? -2.449  13.659  -3.753  1.00 15.10 ? 251 TRP B CZ3 1 
ATOM   3701 C CH2 . TRP B 1 225 ? -2.508  14.262  -2.495  1.00 18.49 ? 251 TRP B CH2 1 
ATOM   3702 N N   . PRO B 1 226 ? 3.496   14.314  -8.348  1.00 15.87 ? 252 PRO B N   1 
ATOM   3703 C CA  . PRO B 1 226 ? 4.228   13.822  -9.521  1.00 18.35 ? 252 PRO B CA  1 
ATOM   3704 C C   . PRO B 1 226 ? 5.423   12.979  -9.124  1.00 22.00 ? 252 PRO B C   1 
ATOM   3705 O O   . PRO B 1 226 ? 6.002   13.138  -8.048  1.00 19.58 ? 252 PRO B O   1 
ATOM   3706 C CB  . PRO B 1 226 ? 4.703   15.104  -10.218 1.00 17.63 ? 252 PRO B CB  1 
ATOM   3707 C CG  . PRO B 1 226 ? 3.986   16.238  -9.550  1.00 16.26 ? 252 PRO B CG  1 
ATOM   3708 C CD  . PRO B 1 226 ? 3.662   15.764  -8.161  1.00 15.03 ? 252 PRO B CD  1 
ATOM   3709 N N   . GLN B 1 227 ? 5.806   12.082  -10.029 1.00 24.33 ? 254 GLN B N   1 
ATOM   3710 C CA  . GLN B 1 227 ? 7.020   11.310  -9.826  1.00 28.14 ? 254 GLN B CA  1 
ATOM   3711 C C   . GLN B 1 227 ? 8.210   12.261  -9.849  1.00 19.95 ? 254 GLN B C   1 
ATOM   3712 O O   . GLN B 1 227 ? 8.414   12.995  -10.822 1.00 25.15 ? 254 GLN B O   1 
ATOM   3713 C CB  . GLN B 1 227 ? 7.153   10.233  -10.903 1.00 30.65 ? 254 GLN B CB  1 
ATOM   3714 C CG  . GLN B 1 227 ? 8.542   9.604   -11.003 1.00 30.34 ? 254 GLN B CG  1 
ATOM   3715 C CD  . GLN B 1 227 ? 9.097   9.588   -12.411 1.00 43.91 ? 254 GLN B CD  1 
ATOM   3716 O OE1 . GLN B 1 227 ? 8.569   8.902   -13.291 1.00 41.65 ? 254 GLN B OE1 1 
ATOM   3717 N NE2 . GLN B 1 227 ? 10.171  10.336  -12.632 1.00 41.98 ? 254 GLN B NE2 1 
ATOM   3718 N N   . GLY B 1 228 ? 8.962   12.283  -8.752  1.00 16.64 ? 255 GLY B N   1 
ATOM   3719 C CA  . GLY B 1 228 ? 10.183  13.050  -8.656  1.00 18.83 ? 255 GLY B CA  1 
ATOM   3720 C C   . GLY B 1 228 ? 10.026  14.524  -8.349  1.00 21.75 ? 255 GLY B C   1 
ATOM   3721 O O   . GLY B 1 228 ? 11.040  15.235  -8.322  1.00 18.39 ? 255 GLY B O   1 
ATOM   3722 N N   A ARG B 1 229 ? 8.806   15.003  -8.102  0.41 19.02 ? 256 ARG B N   1 
ATOM   3723 N N   B ARG B 1 229 ? 8.804   15.006  -8.101  0.59 19.01 ? 256 ARG B N   1 
ATOM   3724 C CA  A ARG B 1 229 ? 8.542   16.424  -7.921  0.41 19.98 ? 256 ARG B CA  1 
ATOM   3725 C CA  B ARG B 1 229 ? 8.526   16.431  -7.956  0.59 20.00 ? 256 ARG B CA  1 
ATOM   3726 C C   A ARG B 1 229 ? 7.742   16.675  -6.649  0.41 16.18 ? 256 ARG B C   1 
ATOM   3727 C C   B ARG B 1 229 ? 7.681   16.694  -6.712  0.59 16.15 ? 256 ARG B C   1 
ATOM   3728 O O   A ARG B 1 229 ? 7.125   15.771  -6.082  0.41 19.21 ? 256 ARG B O   1 
ATOM   3729 O O   B ARG B 1 229 ? 6.974   15.814  -6.219  0.59 18.70 ? 256 ARG B O   1 
ATOM   3730 C CB  A ARG B 1 229 ? 7.744   17.013  -9.093  0.41 17.15 ? 256 ARG B CB  1 
ATOM   3731 C CB  B ARG B 1 229 ? 7.765   16.982  -9.176  0.59 17.09 ? 256 ARG B CB  1 
ATOM   3732 C CG  A ARG B 1 229 ? 8.339   16.799  -10.466 0.41 22.62 ? 256 ARG B CG  1 
ATOM   3733 C CG  B ARG B 1 229 ? 8.370   16.638  -10.531 0.59 22.78 ? 256 ARG B CG  1 
ATOM   3734 C CD  A ARG B 1 229 ? 7.561   17.614  -11.475 0.41 25.52 ? 256 ARG B CD  1 
ATOM   3735 C CD  B ARG B 1 229 ? 7.496   17.163  -11.659 0.59 25.43 ? 256 ARG B CD  1 
ATOM   3736 N NE  A ARG B 1 229 ? 7.460   19.008  -11.058 0.41 24.51 ? 256 ARG B NE  1 
ATOM   3737 N NE  B ARG B 1 229 ? 8.109   16.984  -12.971 0.59 26.32 ? 256 ARG B NE  1 
ATOM   3738 C CZ  A ARG B 1 229 ? 7.936   20.032  -11.751 0.41 28.06 ? 256 ARG B CZ  1 
ATOM   3739 C CZ  B ARG B 1 229 ? 8.735   17.943  -13.641 0.59 21.83 ? 256 ARG B CZ  1 
ATOM   3740 N NH1 A ARG B 1 229 ? 8.528   19.857  -12.920 0.41 26.99 ? 256 ARG B NH1 1 
ATOM   3741 N NH1 B ARG B 1 229 ? 8.870   19.160  -13.141 0.59 30.70 ? 256 ARG B NH1 1 
ATOM   3742 N NH2 A ARG B 1 229 ? 7.807   21.263  -11.263 0.41 29.67 ? 256 ARG B NH2 1 
ATOM   3743 N NH2 B ARG B 1 229 ? 9.236   17.673  -14.844 0.59 23.55 ? 256 ARG B NH2 1 
ATOM   3744 N N   . ALA B 1 230 ? 7.749   17.936  -6.222  1.00 19.17 ? 257 ALA B N   1 
ATOM   3745 C CA  . ALA B 1 230 ? 6.886   18.375  -5.133  1.00 16.29 ? 257 ALA B CA  1 
ATOM   3746 C C   . ALA B 1 230 ? 5.447   18.450  -5.642  1.00 14.43 ? 257 ALA B C   1 
ATOM   3747 O O   . ALA B 1 230 ? 5.218   18.575  -6.844  1.00 15.40 ? 257 ALA B O   1 
ATOM   3748 C CB  . ALA B 1 230 ? 7.334   19.753  -4.634  1.00 14.71 ? 257 ALA B CB  1 
ATOM   3749 N N   . PRO B 1 231 ? 4.457   18.371  -4.756  1.00 11.14 ? 258 PRO B N   1 
ATOM   3750 C CA  . PRO B 1 231 ? 3.072   18.289  -5.232  1.00 13.18 ? 258 PRO B CA  1 
ATOM   3751 C C   . PRO B 1 231 ? 2.587   19.535  -5.957  1.00 14.00 ? 258 PRO B C   1 
ATOM   3752 O O   . PRO B 1 231 ? 3.118   20.642  -5.813  1.00 12.90 ? 258 PRO B O   1 
ATOM   3753 C CB  . PRO B 1 231 ? 2.246   18.023  -3.970  1.00 15.28 ? 258 PRO B CB  1 
ATOM   3754 C CG  . PRO B 1 231 ? 3.160   18.192  -2.830  1.00 18.39 ? 258 PRO B CG  1 
ATOM   3755 C CD  . PRO B 1 231 ? 4.567   18.001  -3.336  1.00 15.40 ? 258 PRO B CD  1 
ATOM   3756 N N   . LEU B 1 232 ? 1.554   19.310  -6.769  1.00 11.37 ? 259 LEU B N   1 
ATOM   3757 C CA  . LEU B 1 232 ? 0.870   20.346  -7.528  1.00 9.92  ? 259 LEU B CA  1 
ATOM   3758 C C   . LEU B 1 232 ? -0.598  20.360  -7.142  1.00 11.33 ? 259 LEU B C   1 
ATOM   3759 O O   . LEU B 1 232 ? -1.159  19.355  -6.708  1.00 11.92 ? 259 LEU B O   1 
ATOM   3760 C CB  . LEU B 1 232 ? 0.908   20.065  -9.040  1.00 11.19 ? 259 LEU B CB  1 
ATOM   3761 C CG  . LEU B 1 232 ? 2.189   19.543  -9.680  1.00 11.28 ? 259 LEU B CG  1 
ATOM   3762 C CD1 . LEU B 1 232 ? 1.896   19.108  -11.101 1.00 15.82 ? 259 LEU B CD1 1 
ATOM   3763 C CD2 . LEU B 1 232 ? 3.244   20.649  -9.644  1.00 13.41 ? 259 LEU B CD2 1 
ATOM   3764 N N   A VAL B 1 233 ? -1.216  21.518  -7.343  0.66 9.53  ? 260 VAL B N   1 
ATOM   3765 N N   B VAL B 1 233 ? -1.225  21.519  -7.265  0.34 9.57  ? 260 VAL B N   1 
ATOM   3766 C CA  A VAL B 1 233 ? -2.653  21.697  -7.213  0.66 9.74  ? 260 VAL B CA  1 
ATOM   3767 C CA  B VAL B 1 233 ? -2.676  21.601  -7.218  0.34 9.81  ? 260 VAL B CA  1 
ATOM   3768 C C   A VAL B 1 233 ? -3.156  22.181  -8.565  0.66 10.84 ? 260 VAL B C   1 
ATOM   3769 C C   B VAL B 1 233 ? -3.153  22.151  -8.552  0.34 10.79 ? 260 VAL B C   1 
ATOM   3770 O O   A VAL B 1 233 ? -2.575  23.107  -9.144  0.66 11.11 ? 260 VAL B O   1 
ATOM   3771 O O   B VAL B 1 233 ? -2.536  23.061  -9.118  0.34 11.04 ? 260 VAL B O   1 
ATOM   3772 C CB  A VAL B 1 233 ? -2.983  22.720  -6.115  0.66 9.20  ? 260 VAL B CB  1 
ATOM   3773 C CB  B VAL B 1 233 ? -3.226  22.389  -6.008  0.34 10.28 ? 260 VAL B CB  1 
ATOM   3774 C CG1 A VAL B 1 233 ? -4.483  22.900  -6.031  0.66 7.60  ? 260 VAL B CG1 1 
ATOM   3775 C CG1 B VAL B 1 233 ? -2.508  21.970  -4.728  0.34 12.29 ? 260 VAL B CG1 1 
ATOM   3776 C CG2 A VAL B 1 233 ? -2.392  22.274  -4.767  0.66 13.19 ? 260 VAL B CG2 1 
ATOM   3777 C CG2 B VAL B 1 233 ? -3.112  23.873  -6.221  0.34 8.32  ? 260 VAL B CG2 1 
ATOM   3778 N N   . LEU B 1 234 ? -4.213  21.551  -9.082  1.00 9.28  ? 261 LEU B N   1 
ATOM   3779 C CA  . LEU B 1 234 ? -4.706  21.878  -10.419 1.00 6.79  ? 261 LEU B CA  1 
ATOM   3780 C C   . LEU B 1 234 ? -6.223  21.901  -10.424 1.00 10.15 ? 261 LEU B C   1 
ATOM   3781 O O   . LEU B 1 234 ? -6.868  20.940  -9.998  1.00 8.61  ? 261 LEU B O   1 
ATOM   3782 C CB  . LEU B 1 234 ? -4.216  20.870  -11.455 1.00 9.09  ? 261 LEU B CB  1 
ATOM   3783 C CG  . LEU B 1 234 ? -4.633  21.121  -12.906 1.00 9.99  ? 261 LEU B CG  1 
ATOM   3784 C CD1 . LEU B 1 234 ? -4.099  22.484  -13.409 1.00 9.55  ? 261 LEU B CD1 1 
ATOM   3785 C CD2 . LEU B 1 234 ? -4.134  19.975  -13.764 1.00 13.11 ? 261 LEU B CD2 1 
ATOM   3786 N N   . VAL B 1 235 ? -6.785  23.006  -10.891 1.00 9.22  ? 262 VAL B N   1 
ATOM   3787 C CA  . VAL B 1 235 ? -8.220  23.160  -11.087 1.00 9.44  ? 262 VAL B CA  1 
ATOM   3788 C C   . VAL B 1 235 ? -8.468  23.328  -12.579 1.00 12.11 ? 262 VAL B C   1 
ATOM   3789 O O   . VAL B 1 235 ? -7.819  24.161  -13.226 1.00 10.03 ? 262 VAL B O   1 
ATOM   3790 C CB  . VAL B 1 235 ? -8.740  24.377  -10.302 1.00 10.44 ? 262 VAL B CB  1 
ATOM   3791 C CG1 . VAL B 1 235 ? -10.173 24.728  -10.725 1.00 17.53 ? 262 VAL B CG1 1 
ATOM   3792 C CG2 . VAL B 1 235 ? -8.596  24.150  -8.800  1.00 13.24 ? 262 VAL B CG2 1 
ATOM   3793 N N   . THR B 1 236 ? -9.392  22.535  -13.128 1.00 9.35  ? 263 THR B N   1 
ATOM   3794 C CA  . THR B 1 236 ? -9.846  22.683  -14.509 1.00 8.65  ? 263 THR B CA  1 
ATOM   3795 C C   . THR B 1 236 ? -11.365 22.762  -14.507 1.00 9.62  ? 263 THR B C   1 
ATOM   3796 O O   . THR B 1 236 ? -12.035 21.800  -14.116 1.00 9.56  ? 263 THR B O   1 
ATOM   3797 C CB  . THR B 1 236 ? -9.358  21.524  -15.406 1.00 7.24  ? 263 THR B CB  1 
ATOM   3798 O OG1 . THR B 1 236 ? -9.885  20.279  -14.932 1.00 9.62  ? 263 THR B OG1 1 
ATOM   3799 C CG2 . THR B 1 236 ? -7.843  21.427  -15.409 1.00 9.62  ? 263 THR B CG2 1 
ATOM   3800 N N   . TYR B 1 237 ? -11.908 23.890  -14.965 1.00 9.38  ? 264 TYR B N   1 
ATOM   3801 C CA  . TYR B 1 237 ? -13.344 24.129  -15.041 1.00 9.60  ? 264 TYR B CA  1 
ATOM   3802 C C   . TYR B 1 237 ? -13.711 24.379  -16.498 1.00 9.45  ? 264 TYR B C   1 
ATOM   3803 O O   . TYR B 1 237 ? -12.952 25.025  -17.230 1.00 9.92  ? 264 TYR B O   1 
ATOM   3804 C CB  . TYR B 1 237 ? -13.688 25.378  -14.206 1.00 8.71  ? 264 TYR B CB  1 
ATOM   3805 C CG  . TYR B 1 237 ? -13.764 25.146  -12.699 1.00 10.51 ? 264 TYR B CG  1 
ATOM   3806 C CD1 . TYR B 1 237 ? -13.962 23.875  -12.180 1.00 14.93 ? 264 TYR B CD1 1 
ATOM   3807 C CD2 . TYR B 1 237 ? -13.714 26.216  -11.806 1.00 14.68 ? 264 TYR B CD2 1 
ATOM   3808 C CE1 . TYR B 1 237 ? -14.078 23.663  -10.810 1.00 14.39 ? 264 TYR B CE1 1 
ATOM   3809 C CE2 . TYR B 1 237 ? -13.830 26.010  -10.430 1.00 15.26 ? 264 TYR B CE2 1 
ATOM   3810 C CZ  . TYR B 1 237 ? -14.023 24.732  -9.950  1.00 11.48 ? 264 TYR B CZ  1 
ATOM   3811 O OH  . TYR B 1 237 ? -14.151 24.526  -8.591  1.00 16.29 ? 264 TYR B OH  1 
ATOM   3812 N N   . PHE B 1 238 ? -14.870 23.876  -16.926 1.00 8.66  ? 265 PHE B N   1 
ATOM   3813 C CA  . PHE B 1 238 ? -15.270 23.970  -18.327 1.00 8.14  ? 265 PHE B CA  1 
ATOM   3814 C C   . PHE B 1 238 ? -16.787 24.052  -18.417 1.00 10.42 ? 265 PHE B C   1 
ATOM   3815 O O   . PHE B 1 238 ? -17.495 23.291  -17.753 1.00 9.51  ? 265 PHE B O   1 
ATOM   3816 C CB  . PHE B 1 238 ? -14.761 22.749  -19.107 1.00 7.55  ? 265 PHE B CB  1 
ATOM   3817 C CG  . PHE B 1 238 ? -15.040 22.814  -20.581 1.00 9.86  ? 265 PHE B CG  1 
ATOM   3818 C CD1 . PHE B 1 238 ? -14.386 23.743  -21.387 1.00 10.82 ? 265 PHE B CD1 1 
ATOM   3819 C CD2 . PHE B 1 238 ? -15.965 21.948  -21.169 1.00 10.21 ? 265 PHE B CD2 1 
ATOM   3820 C CE1 . PHE B 1 238 ? -14.654 23.796  -22.760 1.00 8.58  ? 265 PHE B CE1 1 
ATOM   3821 C CE2 . PHE B 1 238 ? -16.220 22.002  -22.530 1.00 10.83 ? 265 PHE B CE2 1 
ATOM   3822 C CZ  . PHE B 1 238 ? -15.572 22.941  -23.314 1.00 7.50  ? 265 PHE B CZ  1 
ATOM   3823 N N   . THR B 1 239 ? -17.290 24.973  -19.240 1.00 8.36  ? 266 THR B N   1 
ATOM   3824 C CA  . THR B 1 239 ? -18.732 25.140  -19.381 1.00 10.72 ? 266 THR B CA  1 
ATOM   3825 C C   . THR B 1 239 ? -19.047 25.606  -20.797 1.00 10.69 ? 266 THR B C   1 
ATOM   3826 O O   . THR B 1 239 ? -18.206 26.215  -21.458 1.00 11.03 ? 266 THR B O   1 
ATOM   3827 C CB  . THR B 1 239 ? -19.268 26.094  -18.302 1.00 10.23 ? 266 THR B CB  1 
ATOM   3828 O OG1 . THR B 1 239 ? -20.698 26.012  -18.237 1.00 12.27 ? 266 THR B OG1 1 
ATOM   3829 C CG2 . THR B 1 239 ? -18.823 27.525  -18.570 1.00 9.86  ? 266 THR B CG2 1 
ATOM   3830 N N   . GLN B 1 240 ? -20.258 25.308  -21.253 1.00 10.20 ? 267 GLN B N   1 
ATOM   3831 C CA  . GLN B 1 240 ? -20.643 25.432  -22.650 1.00 11.03 ? 267 GLN B CA  1 
ATOM   3832 C C   . GLN B 1 240 ? -21.907 26.269  -22.804 1.00 10.02 ? 267 GLN B C   1 
ATOM   3833 O O   . GLN B 1 240 ? -22.634 26.505  -21.831 1.00 12.11 ? 267 GLN B O   1 
ATOM   3834 C CB  . GLN B 1 240 ? -20.804 24.036  -23.272 1.00 10.57 ? 267 GLN B CB  1 
ATOM   3835 C CG  . GLN B 1 240 ? -19.512 23.212  -23.184 1.00 12.00 ? 267 GLN B CG  1 
ATOM   3836 C CD  . GLN B 1 240 ? -19.671 21.801  -23.688 1.00 11.73 ? 267 GLN B CD  1 
ATOM   3837 O OE1 . GLN B 1 240 ? -19.766 21.567  -24.891 1.00 15.05 ? 267 GLN B OE1 1 
ATOM   3838 N NE2 . GLN B 1 240 ? -19.708 20.842  -22.764 1.00 10.53 ? 267 GLN B NE2 1 
ATOM   3839 N N   . PRO B 1 241 ? -22.188 26.763  -24.018 1.00 10.16 ? 268 PRO B N   1 
ATOM   3840 C CA  . PRO B 1 241 ? -23.268 27.757  -24.163 1.00 9.57  ? 268 PRO B CA  1 
ATOM   3841 C C   . PRO B 1 241 ? -24.680 27.205  -24.149 1.00 12.09 ? 268 PRO B C   1 
ATOM   3842 O O   . PRO B 1 241 ? -25.613 27.972  -23.866 1.00 14.75 ? 268 PRO B O   1 
ATOM   3843 C CB  . PRO B 1 241 ? -22.971 28.407  -25.531 1.00 15.32 ? 268 PRO B CB  1 
ATOM   3844 C CG  . PRO B 1 241 ? -21.596 27.971  -25.888 1.00 16.95 ? 268 PRO B CG  1 
ATOM   3845 C CD  . PRO B 1 241 ? -21.421 26.635  -25.271 1.00 17.46 ? 268 PRO B CD  1 
ATOM   3846 N N   . GLN B 1 242 ? -24.882 25.932  -24.470 1.00 13.35 ? 269 GLN B N   1 
ATOM   3847 C CA  . GLN B 1 242 ? -26.220 25.365  -24.555 1.00 13.60 ? 269 GLN B CA  1 
ATOM   3848 C C   . GLN B 1 242 ? -26.529 24.492  -23.346 1.00 10.86 ? 269 GLN B C   1 
ATOM   3849 O O   . GLN B 1 242 ? -25.691 23.700  -22.889 1.00 11.83 ? 269 GLN B O   1 
ATOM   3850 C CB  . GLN B 1 242 ? -26.390 24.568  -25.844 1.00 18.35 ? 269 GLN B CB  1 
ATOM   3851 C CG  . GLN B 1 242 ? -26.115 25.413  -27.076 1.00 20.45 ? 269 GLN B CG  1 
ATOM   3852 C CD  . GLN B 1 242 ? -27.310 25.526  -27.982 1.00 27.96 ? 269 GLN B CD  1 
ATOM   3853 O OE1 . GLN B 1 242 ? -28.403 25.079  -27.643 1.00 37.97 ? 269 GLN B OE1 1 
ATOM   3854 N NE2 . GLN B 1 242 ? -27.115 26.143  -29.141 1.00 33.96 ? 269 GLN B NE2 1 
ATOM   3855 N N   . GLN B 1 243 ? -27.758 24.629  -22.848 1.00 13.10 ? 270 GLN B N   1 
ATOM   3856 C CA  . GLN B 1 243 ? -28.142 23.979  -21.596 1.00 13.34 ? 270 GLN B CA  1 
ATOM   3857 C C   . GLN B 1 243 ? -27.949 22.470  -21.653 1.00 11.85 ? 270 GLN B C   1 
ATOM   3858 O O   . GLN B 1 243 ? -27.584 21.853  -20.647 1.00 12.37 ? 270 GLN B O   1 
ATOM   3859 C CB  . GLN B 1 243 ? -29.596 24.321  -21.245 1.00 13.03 ? 270 GLN B CB  1 
ATOM   3860 C CG  . GLN B 1 243 ? -29.954 23.962  -19.800 1.00 19.02 ? 270 GLN B CG  1 
ATOM   3861 C CD  . GLN B 1 243 ? -31.435 24.105  -19.518 1.00 23.73 ? 270 GLN B CD  1 
ATOM   3862 O OE1 . GLN B 1 243 ? -32.250 24.161  -20.438 1.00 23.38 ? 270 GLN B OE1 1 
ATOM   3863 N NE2 . GLN B 1 243 ? -31.790 24.193  -18.240 1.00 34.55 ? 270 GLN B NE2 1 
ATOM   3864 N N   A ASN B 1 244 ? -28.198 21.851  -22.808 0.44 13.84 ? 271 ASN B N   1 
ATOM   3865 N N   B ASN B 1 244 ? -28.191 21.862  -22.819 0.56 13.84 ? 271 ASN B N   1 
ATOM   3866 C CA  A ASN B 1 244 ? -28.128 20.400  -22.930 0.44 12.50 ? 271 ASN B CA  1 
ATOM   3867 C CA  B ASN B 1 244 ? -28.155 20.415  -22.991 0.56 12.48 ? 271 ASN B CA  1 
ATOM   3868 C C   A ASN B 1 244 ? -26.839 19.918  -23.584 0.44 12.90 ? 271 ASN B C   1 
ATOM   3869 C C   B ASN B 1 244 ? -26.822 19.887  -23.508 0.56 12.88 ? 271 ASN B C   1 
ATOM   3870 O O   A ASN B 1 244 ? -26.814 18.835  -24.176 0.44 14.50 ? 271 ASN B O   1 
ATOM   3871 O O   B ASN B 1 244 ? -26.761 18.732  -23.939 0.56 14.53 ? 271 ASN B O   1 
ATOM   3872 C CB  A ASN B 1 244 ? -29.356 19.850  -23.654 0.44 13.28 ? 271 ASN B CB  1 
ATOM   3873 C CB  B ASN B 1 244 ? -29.294 19.947  -23.908 0.56 13.79 ? 271 ASN B CB  1 
ATOM   3874 C CG  A ASN B 1 244 ? -30.646 20.295  -23.012 0.44 15.46 ? 271 ASN B CG  1 
ATOM   3875 C CG  B ASN B 1 244 ? -29.246 20.588  -25.297 0.56 19.50 ? 271 ASN B CG  1 
ATOM   3876 O OD1 A ASN B 1 244 ? -30.787 20.254  -21.786 0.44 17.81 ? 271 ASN B OD1 1 
ATOM   3877 O OD1 B ASN B 1 244 ? -28.182 20.943  -25.814 0.56 18.41 ? 271 ASN B OD1 1 
ATOM   3878 N ND2 A ASN B 1 244 ? -31.600 20.723  -23.831 0.44 18.64 ? 271 ASN B ND2 1 
ATOM   3879 N ND2 B ASN B 1 244 ? -30.414 20.708  -25.919 0.56 30.89 ? 271 ASN B ND2 1 
ATOM   3880 N N   . ALA B 1 245 ? -25.764 20.697  -23.479 1.00 12.04 ? 272 ALA B N   1 
ATOM   3881 C CA  . ALA B 1 245 ? -24.486 20.275  -24.035 1.00 13.26 ? 272 ALA B CA  1 
ATOM   3882 C C   . ALA B 1 245 ? -23.962 19.035  -23.323 1.00 14.02 ? 272 ALA B C   1 
ATOM   3883 O O   . ALA B 1 245 ? -24.221 18.808  -22.138 1.00 12.69 ? 272 ALA B O   1 
ATOM   3884 C CB  . ALA B 1 245 ? -23.457 21.399  -23.905 1.00 13.63 ? 272 ALA B CB  1 
ATOM   3885 N N   A GLU B 1 246 ? -23.202 18.236  -24.065 0.45 15.92 ? 273 GLU B N   1 
ATOM   3886 N N   B GLU B 1 246 ? -23.205 18.230  -24.060 0.55 15.92 ? 273 GLU B N   1 
ATOM   3887 C CA  A GLU B 1 246 ? -22.649 17.005  -23.532 0.45 16.33 ? 273 GLU B CA  1 
ATOM   3888 C CA  B GLU B 1 246 ? -22.671 16.995  -23.517 0.55 16.33 ? 273 GLU B CA  1 
ATOM   3889 C C   A GLU B 1 246 ? -21.423 17.290  -22.670 0.45 13.59 ? 273 GLU B C   1 
ATOM   3890 C C   B GLU B 1 246 ? -21.390 17.249  -22.728 0.55 13.57 ? 273 GLU B C   1 
ATOM   3891 O O   A GLU B 1 246 ? -20.770 18.329  -22.788 0.45 14.93 ? 273 GLU B O   1 
ATOM   3892 O O   B GLU B 1 246 ? -20.667 18.223  -22.956 0.55 14.66 ? 273 GLU B O   1 
ATOM   3893 C CB  A GLU B 1 246 ? -22.250 16.067  -24.674 0.45 16.95 ? 273 GLU B CB  1 
ATOM   3894 C CB  B GLU B 1 246 ? -22.382 16.007  -24.647 0.55 17.15 ? 273 GLU B CB  1 
ATOM   3895 C CG  A GLU B 1 246 ? -20.809 16.229  -25.138 0.45 22.77 ? 273 GLU B CG  1 
ATOM   3896 C CG  B GLU B 1 246 ? -23.374 16.071  -25.795 0.55 19.81 ? 273 GLU B CG  1 
ATOM   3897 C CD  A GLU B 1 246 ? -20.683 16.625  -26.597 0.45 25.19 ? 273 GLU B CD  1 
ATOM   3898 C CD  B GLU B 1 246 ? -24.542 15.128  -25.601 0.55 24.76 ? 273 GLU B CD  1 
ATOM   3899 O OE1 A GLU B 1 246 ? -21.210 17.690  -26.979 0.45 29.46 ? 273 GLU B OE1 1 
ATOM   3900 O OE1 B GLU B 1 246 ? -24.335 14.041  -25.023 0.55 31.72 ? 273 GLU B OE1 1 
ATOM   3901 O OE2 A GLU B 1 246 ? -20.044 15.866  -27.358 0.45 20.85 ? 273 GLU B OE2 1 
ATOM   3902 O OE2 B GLU B 1 246 ? -25.663 15.472  -26.034 0.55 30.33 ? 273 GLU B OE2 1 
ATOM   3903 N N   . SER B 1 247 ? -21.110 16.336  -21.801 1.00 13.60 ? 274 SER B N   1 
ATOM   3904 C CA  . SER B 1 247 ? -19.922 16.440  -20.965 1.00 13.04 ? 274 SER B CA  1 
ATOM   3905 C C   . SER B 1 247 ? -18.658 16.335  -21.811 1.00 12.85 ? 274 SER B C   1 
ATOM   3906 O O   . SER B 1 247 ? -18.630 15.662  -22.847 1.00 13.39 ? 274 SER B O   1 
ATOM   3907 C CB  . SER B 1 247 ? -19.911 15.306  -19.940 1.00 13.79 ? 274 SER B CB  1 
ATOM   3908 O OG  . SER B 1 247 ? -20.965 15.452  -18.996 1.00 19.59 ? 274 SER B OG  1 
ATOM   3909 N N   . ARG B 1 248 ? -17.589 17.002  -21.352 1.00 11.74 ? 275 ARG B N   1 
ATOM   3910 C CA  . ARG B 1 248 ? -16.312 17.027  -22.077 1.00 12.44 ? 275 ARG B CA  1 
ATOM   3911 C C   . ARG B 1 248 ? -15.150 16.781  -21.110 1.00 11.61 ? 275 ARG B C   1 
ATOM   3912 O O   . ARG B 1 248 ? -14.278 17.629  -20.917 1.00 11.31 ? 275 ARG B O   1 
ATOM   3913 C CB  . ARG B 1 248 ? -16.116 18.333  -22.846 1.00 10.81 ? 275 ARG B CB  1 
ATOM   3914 C CG  . ARG B 1 248 ? -17.104 18.585  -23.992 1.00 11.56 ? 275 ARG B CG  1 
ATOM   3915 C CD  . ARG B 1 248 ? -17.048 17.555  -25.105 1.00 13.63 ? 275 ARG B CD  1 
ATOM   3916 N NE  . ARG B 1 248 ? -15.703 17.391  -25.639 1.00 13.91 ? 275 ARG B NE  1 
ATOM   3917 C CZ  . ARG B 1 248 ? -15.218 17.974  -26.729 1.00 14.19 ? 275 ARG B CZ  1 
ATOM   3918 N NH1 . ARG B 1 248 ? -15.938 18.822  -27.449 1.00 14.72 ? 275 ARG B NH1 1 
ATOM   3919 N NH2 . ARG B 1 248 ? -13.980 17.677  -27.123 1.00 16.01 ? 275 ARG B NH2 1 
ATOM   3920 N N   . ARG B 1 249 ? -15.126 15.592  -20.506 1.00 11.02 ? 276 ARG B N   1 
ATOM   3921 C CA  . ARG B 1 249 ? -14.019 15.242  -19.624 1.00 10.41 ? 276 ARG B CA  1 
ATOM   3922 C C   . ARG B 1 249 ? -12.698 15.204  -20.377 1.00 11.42 ? 276 ARG B C   1 
ATOM   3923 O O   . ARG B 1 249 ? -11.649 15.506  -19.797 1.00 10.89 ? 276 ARG B O   1 
ATOM   3924 C CB  . ARG B 1 249 ? -14.314 13.920  -18.921 1.00 13.89 ? 276 ARG B CB  1 
ATOM   3925 C CG  . ARG B 1 249 ? -15.401 14.068  -17.859 1.00 11.62 ? 276 ARG B CG  1 
ATOM   3926 C CD  . ARG B 1 249 ? -15.750 12.776  -17.143 1.00 16.32 ? 276 ARG B CD  1 
ATOM   3927 N NE  . ARG B 1 249 ? -16.142 11.724  -18.075 1.00 29.97 ? 276 ARG B NE  1 
ATOM   3928 C CZ  . ARG B 1 249 ? -16.476 10.490  -17.720 1.00 37.81 ? 276 ARG B CZ  1 
ATOM   3929 N NH1 . ARG B 1 249 ? -16.485 10.113  -16.450 1.00 37.21 ? 276 ARG B NH1 1 
ATOM   3930 N NH2 . ARG B 1 249 ? -16.804 9.610   -18.664 1.00 30.25 ? 276 ARG B NH2 1 
ATOM   3931 N N   . ASP B 1 250 ? -12.739 14.892  -21.679 1.00 11.76 ? 277 ASP B N   1 
ATOM   3932 C CA  . ASP B 1 250 ? -11.521 14.886  -22.478 1.00 10.08 ? 277 ASP B CA  1 
ATOM   3933 C C   . ASP B 1 250 ? -10.871 16.261  -22.535 1.00 11.80 ? 277 ASP B C   1 
ATOM   3934 O O   . ASP B 1 250 ? -9.647  16.356  -22.680 1.00 12.68 ? 277 ASP B O   1 
ATOM   3935 C CB  . ASP B 1 250 ? -11.837 14.395  -23.892 1.00 13.14 ? 277 ASP B CB  1 
ATOM   3936 C CG  . ASP B 1 250 ? -12.695 15.370  -24.656 1.00 17.52 ? 277 ASP B CG  1 
ATOM   3937 O OD1 . ASP B 1 250 ? -13.845 15.610  -24.241 1.00 14.32 ? 277 ASP B OD1 1 
ATOM   3938 O OD2 . ASP B 1 250 ? -12.192 15.938  -25.650 1.00 23.27 ? 277 ASP B OD2 1 
ATOM   3939 N N   . VAL B 1 251 ? -11.665 17.336  -22.451 1.00 10.98 ? 278 VAL B N   1 
ATOM   3940 C CA  . VAL B 1 251 ? -11.079 18.675  -22.478 1.00 11.77 ? 278 VAL B CA  1 
ATOM   3941 C C   . VAL B 1 251 ? -10.288 18.939  -21.205 1.00 10.31 ? 278 VAL B C   1 
ATOM   3942 O O   . VAL B 1 251 ? -9.227  19.571  -21.237 1.00 9.98  ? 278 VAL B O   1 
ATOM   3943 C CB  . VAL B 1 251 ? -12.160 19.740  -22.741 1.00 11.84 ? 278 VAL B CB  1 
ATOM   3944 C CG1 . VAL B 1 251 ? -11.615 21.162  -22.538 1.00 9.48  ? 278 VAL B CG1 1 
ATOM   3945 C CG2 . VAL B 1 251 ? -12.724 19.562  -24.135 1.00 13.56 ? 278 VAL B CG2 1 
ATOM   3946 N N   . LEU B 1 252 ? -10.772 18.437  -20.065 1.00 10.74 ? 279 LEU B N   1 
ATOM   3947 C CA  . LEU B 1 252 ? -10.003 18.576  -18.836 1.00 8.16  ? 279 LEU B CA  1 
ATOM   3948 C C   . LEU B 1 252 ? -8.713  17.770  -18.900 1.00 9.35  ? 279 LEU B C   1 
ATOM   3949 O O   . LEU B 1 252 ? -7.662  18.238  -18.459 1.00 10.17 ? 279 LEU B O   1 
ATOM   3950 C CB  . LEU B 1 252 ? -10.850 18.124  -17.640 1.00 9.27  ? 279 LEU B CB  1 
ATOM   3951 C CG  . LEU B 1 252 ? -12.255 18.730  -17.566 1.00 9.89  ? 279 LEU B CG  1 
ATOM   3952 C CD1 . LEU B 1 252 ? -12.894 18.287  -16.265 1.00 10.68 ? 279 LEU B CD1 1 
ATOM   3953 C CD2 . LEU B 1 252 ? -12.175 20.245  -17.641 1.00 12.01 ? 279 LEU B CD2 1 
ATOM   3954 N N   . ALA B 1 253 ? -8.785  16.544  -19.423 1.00 8.92  ? 280 ALA B N   1 
ATOM   3955 C CA  . ALA B 1 253 ? -7.571  15.759  -19.608 1.00 11.28 ? 280 ALA B CA  1 
ATOM   3956 C C   . ALA B 1 253 ? -6.583  16.482  -20.517 1.00 11.03 ? 280 ALA B C   1 
ATOM   3957 O O   . ALA B 1 253 ? -5.379  16.499  -20.241 1.00 12.36 ? 280 ALA B O   1 
ATOM   3958 C CB  . ALA B 1 253 ? -7.930  14.389  -20.172 1.00 12.16 ? 280 ALA B CB  1 
ATOM   3959 N N   . SER B 1 254 ? -7.079  17.104  -21.595 1.00 10.03 ? 281 SER B N   1 
ATOM   3960 C CA  . SER B 1 254 ? -6.202  17.826  -22.511 1.00 10.14 ? 281 SER B CA  1 
ATOM   3961 C C   . SER B 1 254 ? -5.542  19.018  -21.833 1.00 11.25 ? 281 SER B C   1 
ATOM   3962 O O   . SER B 1 254 ? -4.364  19.313  -22.089 1.00 10.82 ? 281 SER B O   1 
ATOM   3963 C CB  . SER B 1 254 ? -6.983  18.280  -23.743 1.00 10.18 ? 281 SER B CB  1 
ATOM   3964 O OG  . SER B 1 254 ? -7.382  17.159  -24.509 1.00 13.59 ? 281 SER B OG  1 
ATOM   3965 N N   . ALA B 1 255 ? -6.289  19.729  -20.977 1.00 9.94  ? 282 ALA B N   1 
ATOM   3966 C CA  . ALA B 1 255 ? -5.704  20.849  -20.255 1.00 10.08 ? 282 ALA B CA  1 
ATOM   3967 C C   . ALA B 1 255 ? -4.630  20.370  -19.294 1.00 10.90 ? 282 ALA B C   1 
ATOM   3968 O O   . ALA B 1 255 ? -3.560  20.982  -19.198 1.00 11.32 ? 282 ALA B O   1 
ATOM   3969 C CB  . ALA B 1 255 ? -6.791  21.615  -19.499 1.00 10.75 ? 282 ALA B CB  1 
ATOM   3970 N N   . ALA B 1 256 ? -4.902  19.275  -18.579 1.00 10.58 ? 283 ALA B N   1 
ATOM   3971 C CA  . ALA B 1 256 ? -3.925  18.728  -17.647 1.00 9.46  ? 283 ALA B CA  1 
ATOM   3972 C C   . ALA B 1 256 ? -2.667  18.287  -18.381 1.00 11.98 ? 283 ALA B C   1 
ATOM   3973 O O   . ALA B 1 256 ? -1.554  18.508  -17.896 1.00 11.30 ? 283 ALA B O   1 
ATOM   3974 C CB  . ALA B 1 256 ? -4.537  17.546  -16.902 1.00 9.80  ? 283 ALA B CB  1 
ATOM   3975 N N   . ARG B 1 257 ? -2.832  17.686  -19.564 1.00 10.09 ? 284 ARG B N   1 
ATOM   3976 C CA  . ARG B 1 257 ? -1.693  17.267  -20.373 1.00 11.34 ? 284 ARG B CA  1 
ATOM   3977 C C   . ARG B 1 257 ? -0.824  18.456  -20.759 1.00 14.07 ? 284 ARG B C   1 
ATOM   3978 O O   . ARG B 1 257 ? 0.398   18.391  -20.658 1.00 13.04 ? 284 ARG B O   1 
ATOM   3979 C CB  . ARG B 1 257 ? -2.167  16.490  -21.604 1.00 11.13 ? 284 ARG B CB  1 
ATOM   3980 C CG  . ARG B 1 257 ? -1.024  16.044  -22.515 1.00 18.30 ? 284 ARG B CG  1 
ATOM   3981 C CD  . ARG B 1 257 ? -1.488  15.059  -23.580 1.00 15.41 ? 284 ARG B CD  1 
ATOM   3982 N NE  . ARG B 1 257 ? -1.815  13.769  -22.994 1.00 19.19 ? 284 ARG B NE  1 
ATOM   3983 C CZ  . ARG B 1 257 ? -3.046  13.351  -22.730 1.00 32.32 ? 284 ARG B CZ  1 
ATOM   3984 N NH1 . ARG B 1 257 ? -4.105  14.099  -23.004 1.00 30.89 ? 284 ARG B NH1 1 
ATOM   3985 N NH2 . ARG B 1 257 ? -3.219  12.148  -22.187 1.00 33.24 ? 284 ARG B NH2 1 
ATOM   3986 N N   . ILE B 1 258 ? -1.438  19.556  -21.196 1.00 10.95 ? 285 ILE B N   1 
ATOM   3987 C CA  . ILE B 1 258 ? -0.664  20.761  -21.511 1.00 9.99  ? 285 ILE B CA  1 
ATOM   3988 C C   . ILE B 1 258 ? 0.074   21.274  -20.281 1.00 12.47 ? 285 ILE B C   1 
ATOM   3989 O O   . ILE B 1 258 ? 1.255   21.640  -20.357 1.00 11.13 ? 285 ILE B O   1 
ATOM   3990 C CB  . ILE B 1 258 ? -1.587  21.840  -22.102 1.00 11.01 ? 285 ILE B CB  1 
ATOM   3991 C CG1 . ILE B 1 258 ? -2.024  21.455  -23.513 1.00 9.76  ? 285 ILE B CG1 1 
ATOM   3992 C CG2 . ILE B 1 258 ? -0.932  23.240  -22.040 1.00 12.34 ? 285 ILE B CG2 1 
ATOM   3993 C CD1 . ILE B 1 258 ? -3.307  22.140  -23.936 1.00 11.19 ? 285 ILE B CD1 1 
ATOM   3994 N N   . ILE B 1 259 ? -0.608  21.305  -19.129 1.00 10.23 ? 286 ILE B N   1 
ATOM   3995 C CA  . ILE B 1 259 ? 0.029   21.743  -17.888 1.00 10.20 ? 286 ILE B CA  1 
ATOM   3996 C C   . ILE B 1 259 ? 1.247   20.884  -17.577 1.00 13.18 ? 286 ILE B C   1 
ATOM   3997 O O   . ILE B 1 259 ? 2.313   21.402  -17.223 1.00 14.54 ? 286 ILE B O   1 
ATOM   3998 C CB  . ILE B 1 259 ? -0.986  21.754  -16.726 1.00 11.73 ? 286 ILE B CB  1 
ATOM   3999 C CG1 . ILE B 1 259 ? -1.956  22.933  -16.858 1.00 13.70 ? 286 ILE B CG1 1 
ATOM   4000 C CG2 . ILE B 1 259 ? -0.265  21.822  -15.381 1.00 16.46 ? 286 ILE B CG2 1 
ATOM   4001 C CD1 . ILE B 1 259 ? -1.312  24.287  -16.740 1.00 17.40 ? 286 ILE B CD1 1 
ATOM   4002 N N   . ALA B 1 260 ? 1.109   19.559  -17.708 1.00 12.46 ? 287 ALA B N   1 
ATOM   4003 C CA  . ALA B 1 260 ? 2.208   18.655  -17.367 1.00 14.50 ? 287 ALA B CA  1 
ATOM   4004 C C   . ALA B 1 260 ? 3.401   18.843  -18.292 1.00 16.70 ? 287 ALA B C   1 
ATOM   4005 O O   . ALA B 1 260 ? 4.549   18.829  -17.834 1.00 19.61 ? 287 ALA B O   1 
ATOM   4006 C CB  . ALA B 1 260 ? 1.734   17.208  -17.399 1.00 14.51 ? 287 ALA B CB  1 
ATOM   4007 N N   . GLU B 1 261 ? 3.151   19.013  -19.594 1.00 15.92 ? 288 GLU B N   1 
ATOM   4008 C CA  . GLU B 1 261 ? 4.244   19.198  -20.550 1.00 17.87 ? 288 GLU B CA  1 
ATOM   4009 C C   . GLU B 1 261 ? 4.966   20.522  -20.363 1.00 18.62 ? 288 GLU B C   1 
ATOM   4010 O O   . GLU B 1 261 ? 6.132   20.637  -20.754 1.00 25.65 ? 288 GLU B O   1 
ATOM   4011 C CB  . GLU B 1 261 ? 3.750   18.996  -21.993 1.00 17.75 ? 288 GLU B CB  1 
ATOM   4012 C CG  . GLU B 1 261 ? 2.681   17.919  -22.079 1.00 27.70 ? 288 GLU B CG  1 
ATOM   4013 C CD  . GLU B 1 261 ? 2.489   17.259  -23.434 1.00 35.53 ? 288 GLU B CD  1 
ATOM   4014 O OE1 . GLU B 1 261 ? 2.309   17.982  -24.437 1.00 38.80 ? 288 GLU B OE1 1 
ATOM   4015 O OE2 . GLU B 1 261 ? 2.453   16.008  -23.479 1.00 27.13 ? 288 GLU B OE2 1 
ATOM   4016 N N   . GLY B 1 262 ? 4.314   21.507  -19.754 1.00 18.06 ? 289 GLY B N   1 
ATOM   4017 C CA  . GLY B 1 262 ? 4.931   22.793  -19.506 1.00 20.53 ? 289 GLY B CA  1 
ATOM   4018 C C   . GLY B 1 262 ? 5.827   22.860  -18.290 1.00 27.33 ? 289 GLY B C   1 
ATOM   4019 O O   . GLY B 1 262 ? 6.518   23.868  -18.105 1.00 28.43 ? 289 GLY B O   1 
ATOM   4020 N N   . LEU B 1 263 ? 5.830   21.830  -17.450 1.00 21.35 ? 290 LEU B N   1 
ATOM   4021 C CA  . LEU B 1 263 ? 6.676   21.847  -16.263 1.00 25.66 ? 290 LEU B CA  1 
ATOM   4022 C C   . LEU B 1 263 ? 8.135   21.695  -16.668 1.00 30.52 ? 290 LEU B C   1 
ATOM   4023 O O   . LEU B 1 263 ? 8.457   20.839  -17.491 1.00 36.57 ? 290 LEU B O   1 
ATOM   4024 C CB  . LEU B 1 263 ? 6.302   20.718  -15.309 1.00 21.13 ? 290 LEU B CB  1 
ATOM   4025 C CG  . LEU B 1 263 ? 4.905   20.812  -14.703 1.00 21.71 ? 290 LEU B CG  1 
ATOM   4026 C CD1 . LEU B 1 263 ? 4.543   19.500  -14.013 1.00 26.72 ? 290 LEU B CD1 1 
ATOM   4027 C CD2 . LEU B 1 263 ? 4.829   21.976  -13.735 1.00 31.69 ? 290 LEU B CD2 1 
ATOM   4028 O OXT . LEU B 1 263 ? 9.012   22.410  -16.178 1.00 46.90 ? 290 LEU B OXT 1 
HETATM 4029 O OAC . NXL C 2 .   ? -2.656  -3.795  -15.808 0.87 7.99  ? 301 NXL A OAC 1 
HETATM 4030 C CAN . NXL C 2 .   ? -2.203  -3.505  -14.711 0.87 9.09  ? 301 NXL A CAN 1 
HETATM 4031 N N   . NXL C 2 .   ? -1.196  -2.638  -14.505 0.87 11.56 ? 301 NXL A N   1 
HETATM 4032 C CAJ . NXL C 2 .   ? -0.860  -2.148  -13.164 0.87 10.58 ? 301 NXL A CAJ 1 
HETATM 4033 C CA  . NXL C 2 .   ? -0.481  -2.051  -15.651 0.87 10.52 ? 301 NXL A CA  1 
HETATM 4034 C C   . NXL C 2 .   ? 0.998   -2.486  -15.783 0.87 11.98 ? 301 NXL A C   1 
HETATM 4035 O O   . NXL C 2 .   ? 1.565   -2.509  -16.877 0.87 16.12 ? 301 NXL A O   1 
HETATM 4036 N NAA . NXL C 2 .   ? 1.619   -2.833  -14.674 0.87 13.44 ? 301 NXL A NAA 1 
HETATM 4037 C CB  . NXL C 2 .   ? -0.663  -0.536  -15.617 0.87 12.84 ? 301 NXL A CB  1 
HETATM 4038 C CAH . NXL C 2 .   ? -0.476  0.065   -14.224 0.87 17.64 ? 301 NXL A CAH 1 
HETATM 4039 C CAO . NXL C 2 .   ? -1.319  -0.691  -13.202 0.87 11.79 ? 301 NXL A CAO 1 
HETATM 4040 N NAK . NXL C 2 .   ? -2.714  -0.874  -13.645 0.87 21.23 ? 301 NXL A NAK 1 
HETATM 4041 O OAL . NXL C 2 .   ? -3.417  0.381   -13.687 0.87 17.70 ? 301 NXL A OAL 1 
HETATM 4042 S SAR . NXL C 2 .   ? -4.746  0.238   -14.616 0.87 19.08 ? 301 NXL A SAR 1 
HETATM 4043 O OAD . NXL C 2 .   ? -5.464  -0.889  -14.072 0.87 19.12 ? 301 NXL A OAD 1 
HETATM 4044 O OAE . NXL C 2 .   ? -4.289  0.056   -15.975 0.87 20.38 ? 301 NXL A OAE 1 
HETATM 4045 O OAG . NXL C 2 .   ? -5.339  1.531   -14.348 0.87 19.68 ? 301 NXL A OAG 1 
HETATM 4046 P P   . PO4 D 3 .   ? -27.933 -14.927 -3.338  1.00 25.63 ? 302 PO4 A P   1 
HETATM 4047 O O1  . PO4 D 3 .   ? -27.036 -13.737 -3.587  1.00 31.11 ? 302 PO4 A O1  1 
HETATM 4048 O O2  . PO4 D 3 .   ? -29.383 -14.507 -3.500  1.00 25.80 ? 302 PO4 A O2  1 
HETATM 4049 O O3  . PO4 D 3 .   ? -27.598 -16.002 -4.352  1.00 29.73 ? 302 PO4 A O3  1 
HETATM 4050 O O4  . PO4 D 3 .   ? -27.692 -15.459 -1.941  1.00 28.85 ? 302 PO4 A O4  1 
HETATM 4051 O OAC . NXL E 2 .   ? -21.365 17.606  -9.941  0.87 8.57  ? 301 NXL B OAC 1 
HETATM 4052 C CAN . NXL E 2 .   ? -21.904 16.880  -9.129  0.87 8.66  ? 301 NXL B CAN 1 
HETATM 4053 N N   . NXL E 2 .   ? -22.912 16.051  -9.409  0.87 10.43 ? 301 NXL B N   1 
HETATM 4054 C CAJ . NXL E 2 .   ? -23.262 14.919  -8.543  0.87 9.76  ? 301 NXL B CAJ 1 
HETATM 4055 C CA  . NXL E 2 .   ? -23.604 16.184  -10.699 0.87 9.74  ? 301 NXL B CA  1 
HETATM 4056 C C   . NXL E 2 .   ? -25.079 16.599  -10.536 0.87 13.45 ? 301 NXL B C   1 
HETATM 4057 O O   . NXL E 2 .   ? -25.723 16.348  -9.520  0.87 13.40 ? 301 NXL B O   1 
HETATM 4058 N NAA . NXL E 2 .   ? -25.605 17.247  -11.565 0.87 14.62 ? 301 NXL B NAA 1 
HETATM 4059 C CB  . NXL E 2 .   ? -23.394 14.896  -11.489 0.87 11.50 ? 301 NXL B CB  1 
HETATM 4060 C CAH . NXL E 2 .   ? -23.629 13.644  -10.643 0.87 14.10 ? 301 NXL B CAH 1 
HETATM 4061 C CAO . NXL E 2 .   ? -22.800 13.713  -9.363  0.87 9.92  ? 301 NXL B CAO 1 
HETATM 4062 N NAK . NXL E 2 .   ? -21.391 14.059  -9.646  0.87 14.59 ? 301 NXL B NAK 1 
HETATM 4063 O OAL . NXL E 2 .   ? -20.718 12.960  -10.286 0.87 14.13 ? 301 NXL B OAL 1 
HETATM 4064 S SAR . NXL E 2 .   ? -19.378 13.506  -11.040 0.87 17.73 ? 301 NXL B SAR 1 
HETATM 4065 O OAD . NXL E 2 .   ? -18.684 14.312  -10.061 0.87 17.83 ? 301 NXL B OAD 1 
HETATM 4066 O OAE . NXL E 2 .   ? -19.866 14.250  -12.179 0.87 19.49 ? 301 NXL B OAE 1 
HETATM 4067 O OAG . NXL E 2 .   ? -18.735 12.252  -11.357 0.87 18.71 ? 301 NXL B OAG 1 
HETATM 4068 P P   . PO4 F 3 .   ? -28.016 38.547  -8.041  1.00 33.54 ? 302 PO4 B P   1 
HETATM 4069 O O1  . PO4 F 3 .   ? -27.147 39.766  -8.248  1.00 34.32 ? 302 PO4 B O1  1 
HETATM 4070 O O2  . PO4 F 3 .   ? -29.450 39.000  -7.832  1.00 28.77 ? 302 PO4 B O2  1 
HETATM 4071 O O3  . PO4 F 3 .   ? -27.937 37.628  -9.246  1.00 26.58 ? 302 PO4 B O3  1 
HETATM 4072 O O4  . PO4 F 3 .   ? -27.545 37.809  -6.808  1.00 32.06 ? 302 PO4 B O4  1 
HETATM 4073 P P   . PO4 G 3 .   ? -24.448 -2.767  0.914   1.00 43.73 ? 303 PO4 B P   1 
HETATM 4074 O O1  . PO4 G 3 .   ? -23.959 -2.146  -0.376  1.00 29.20 ? 303 PO4 B O1  1 
HETATM 4075 O O2  . PO4 G 3 .   ? -25.404 -3.891  0.584   1.00 37.89 ? 303 PO4 B O2  1 
HETATM 4076 O O3  . PO4 G 3 .   ? -23.265 -3.316  1.681   1.00 45.00 ? 303 PO4 B O3  1 
HETATM 4077 O O4  . PO4 G 3 .   ? -25.142 -1.720  1.763   1.00 40.90 ? 303 PO4 B O4  1 
HETATM 4078 O O   . HOH H 4 .   ? -15.565 -25.936 -17.945 1.00 23.25 ? 401 HOH A O   1 
HETATM 4079 O O   . HOH H 4 .   ? -2.939  9.672   -29.913 1.00 25.98 ? 402 HOH A O   1 
HETATM 4080 O O   . HOH H 4 .   ? -21.660 -20.251 -7.967  1.00 24.70 ? 403 HOH A O   1 
HETATM 4081 O O   . HOH H 4 .   ? -2.738  -7.142  11.621  1.00 29.44 ? 404 HOH A O   1 
HETATM 4082 O O   . HOH H 4 .   ? -20.915 3.401   -10.161 1.00 19.78 ? 405 HOH A O   1 
HETATM 4083 O O   . HOH H 4 .   ? 11.497  -6.119  -7.148  1.00 19.09 ? 406 HOH A O   1 
HETATM 4084 O O   . HOH H 4 .   ? -2.371  -13.431 -29.087 1.00 30.07 ? 407 HOH A O   1 
HETATM 4085 O O   . HOH H 4 .   ? -0.367  2.108   -32.679 1.00 32.04 ? 408 HOH A O   1 
HETATM 4086 O O   . HOH H 4 .   ? -26.143 -15.813 -0.003  1.00 23.00 ? 409 HOH A O   1 
HETATM 4087 O O   . HOH H 4 .   ? -29.084 -4.206  -10.807 1.00 25.05 ? 410 HOH A O   1 
HETATM 4088 O O   . HOH H 4 .   ? 1.394   -0.633  7.764   1.00 26.12 ? 411 HOH A O   1 
HETATM 4089 O O   . HOH H 4 .   ? -30.488 -6.703  -16.848 1.00 17.15 ? 412 HOH A O   1 
HETATM 4090 O O   . HOH H 4 .   ? -3.727  3.801   -9.247  1.00 20.25 ? 413 HOH A O   1 
HETATM 4091 O O   . HOH H 4 .   ? 3.430   -0.530  -22.561 1.00 25.83 ? 414 HOH A O   1 
HETATM 4092 O O   . HOH H 4 .   ? -36.180 -13.293 -16.696 1.00 24.94 ? 415 HOH A O   1 
HETATM 4093 O O   . HOH H 4 .   ? -32.440 -8.430  -20.919 1.00 34.09 ? 416 HOH A O   1 
HETATM 4094 O O   . HOH H 4 .   ? -26.898 -17.694 -23.277 1.00 23.32 ? 417 HOH A O   1 
HETATM 4095 O O   . HOH H 4 .   ? -16.291 -18.639 -30.673 1.00 18.77 ? 418 HOH A O   1 
HETATM 4096 O O   . HOH H 4 .   ? -11.000 -16.278 -16.732 1.00 12.62 ? 419 HOH A O   1 
HETATM 4097 O O   . HOH H 4 .   ? -14.099 4.360   -29.386 1.00 32.86 ? 420 HOH A O   1 
HETATM 4098 O O   . HOH H 4 .   ? -8.721  -1.434  -39.447 1.00 29.12 ? 421 HOH A O   1 
HETATM 4099 O O   . HOH H 4 .   ? -8.224  3.217   -37.942 1.00 24.50 ? 422 HOH A O   1 
HETATM 4100 O O   . HOH H 4 .   ? 6.808   -5.205  -20.786 1.00 32.27 ? 423 HOH A O   1 
HETATM 4101 O O   . HOH H 4 .   ? -22.730 5.601   -11.083 1.00 20.41 ? 424 HOH A O   1 
HETATM 4102 O O   . HOH H 4 .   ? -1.961  0.331   -23.228 1.00 18.30 ? 425 HOH A O   1 
HETATM 4103 O O   . HOH H 4 .   ? -28.446 0.893   -10.079 1.00 25.98 ? 426 HOH A O   1 
HETATM 4104 O O   . HOH H 4 .   ? 4.163   -21.113 -17.370 1.00 26.70 ? 427 HOH A O   1 
HETATM 4105 O O   . HOH H 4 .   ? -31.506 -17.084 -22.086 1.00 24.68 ? 428 HOH A O   1 
HETATM 4106 O O   . HOH H 4 .   ? -12.889 -15.746 -32.795 1.00 17.32 ? 429 HOH A O   1 
HETATM 4107 O O   . HOH H 4 .   ? -0.767  -6.079  -14.178 1.00 15.80 ? 430 HOH A O   1 
HETATM 4108 O O   . HOH H 4 .   ? 6.064   -6.734  -24.638 1.00 14.28 ? 431 HOH A O   1 
HETATM 4109 O O   . HOH H 4 .   ? -18.745 5.872   -8.482  1.00 22.67 ? 432 HOH A O   1 
HETATM 4110 O O   . HOH H 4 .   ? -3.296  -13.213 11.364  1.00 32.41 ? 433 HOH A O   1 
HETATM 4111 O O   . HOH H 4 .   ? -14.384 -27.322 -7.200  1.00 15.03 ? 434 HOH A O   1 
HETATM 4112 O O   . HOH H 4 .   ? -21.213 -17.538 -19.345 1.00 18.38 ? 435 HOH A O   1 
HETATM 4113 O O   . HOH H 4 .   ? -1.127  -20.595 0.388   1.00 20.12 ? 436 HOH A O   1 
HETATM 4114 O O   . HOH H 4 .   ? 7.399   -7.619  -5.812  1.00 15.91 ? 437 HOH A O   1 
HETATM 4115 O O   . HOH H 4 .   ? -21.204 -14.786 6.495   1.00 25.43 ? 438 HOH A O   1 
HETATM 4116 O O   . HOH H 4 .   ? -25.282 -3.189  -6.109  1.00 28.13 ? 439 HOH A O   1 
HETATM 4117 O O   . HOH H 4 .   ? 10.772  -0.008  -8.159  1.00 33.12 ? 440 HOH A O   1 
HETATM 4118 O O   B HOH H 4 .   ? -15.661 2.596   -8.578  0.84 11.38 ? 441 HOH A O   1 
HETATM 4119 O O   . HOH H 4 .   ? 0.792   0.453   -22.848 1.00 9.16  ? 442 HOH A O   1 
HETATM 4120 O O   . HOH H 4 .   ? -0.496  -12.718 -25.258 1.00 14.33 ? 443 HOH A O   1 
HETATM 4121 O O   . HOH H 4 .   ? -8.751  -19.524 -27.084 1.00 19.74 ? 444 HOH A O   1 
HETATM 4122 O O   . HOH H 4 .   ? -28.637 -11.416 -11.002 1.00 28.30 ? 445 HOH A O   1 
HETATM 4123 O O   . HOH H 4 .   ? -6.351  -5.652  7.769   1.00 19.83 ? 446 HOH A O   1 
HETATM 4124 O O   . HOH H 4 .   ? -24.913 4.302   -22.322 1.00 23.70 ? 447 HOH A O   1 
HETATM 4125 O O   . HOH H 4 .   ? -23.827 -17.398 -16.734 1.00 22.71 ? 448 HOH A O   1 
HETATM 4126 O O   . HOH H 4 .   ? -13.013 7.165   -22.132 1.00 20.35 ? 449 HOH A O   1 
HETATM 4127 O O   . HOH H 4 .   ? 0.529   -12.739 -22.757 1.00 15.41 ? 450 HOH A O   1 
HETATM 4128 O O   . HOH H 4 .   ? -6.615  -1.392  7.581   1.00 27.28 ? 451 HOH A O   1 
HETATM 4129 O O   . HOH H 4 .   ? 3.216   -12.200 -23.402 1.00 13.14 ? 452 HOH A O   1 
HETATM 4130 O O   . HOH H 4 .   ? -26.895 -16.259 -6.947  1.00 25.78 ? 453 HOH A O   1 
HETATM 4131 O O   . HOH H 4 .   ? -1.174  -8.380  -27.984 1.00 16.05 ? 454 HOH A O   1 
HETATM 4132 O O   . HOH H 4 .   ? -12.969 -13.516 4.963   1.00 16.47 ? 455 HOH A O   1 
HETATM 4133 O O   . HOH H 4 .   ? 7.740   -10.407 -13.340 1.00 12.84 ? 456 HOH A O   1 
HETATM 4134 O O   . HOH H 4 .   ? -23.535 -9.779  -4.935  1.00 24.98 ? 457 HOH A O   1 
HETATM 4135 O O   . HOH H 4 .   ? -9.022  -12.060 -12.780 1.00 18.34 ? 458 HOH A O   1 
HETATM 4136 O O   . HOH H 4 .   ? 1.862   -0.228  -25.458 1.00 14.58 ? 459 HOH A O   1 
HETATM 4137 O O   . HOH H 4 .   ? 1.986   -7.447  -33.952 1.00 27.03 ? 460 HOH A O   1 
HETATM 4138 O O   . HOH H 4 .   ? 1.166   -10.782 -21.076 1.00 14.85 ? 461 HOH A O   1 
HETATM 4139 O O   . HOH H 4 .   ? -12.778 -14.214 9.806   1.00 25.58 ? 462 HOH A O   1 
HETATM 4140 O O   . HOH H 4 .   ? -6.892  -24.081 -20.535 1.00 25.96 ? 463 HOH A O   1 
HETATM 4141 O O   . HOH H 4 .   ? 0.672   -4.892  8.847   1.00 18.09 ? 464 HOH A O   1 
HETATM 4142 O O   . HOH H 4 .   ? -13.304 -5.774  -37.290 1.00 18.62 ? 465 HOH A O   1 
HETATM 4143 O O   . HOH H 4 .   ? -26.725 -7.900  -7.014  1.00 24.92 ? 466 HOH A O   1 
HETATM 4144 O O   . HOH H 4 .   ? -1.402  -7.698  -30.735 1.00 22.91 ? 467 HOH A O   1 
HETATM 4145 O O   . HOH H 4 .   ? -4.688  -22.228 -4.946  1.00 21.09 ? 468 HOH A O   1 
HETATM 4146 O O   . HOH H 4 .   ? -13.810 -21.606 -19.496 1.00 20.36 ? 469 HOH A O   1 
HETATM 4147 O O   . HOH H 4 .   ? -1.587  -10.646 -18.945 1.00 14.79 ? 470 HOH A O   1 
HETATM 4148 O O   . HOH H 4 .   ? 9.003   -11.682 -9.477  1.00 20.17 ? 471 HOH A O   1 
HETATM 4149 O O   . HOH H 4 .   ? 3.553   -21.034 -9.663  1.00 26.29 ? 472 HOH A O   1 
HETATM 4150 O O   . HOH H 4 .   ? -8.756  -3.962  -36.465 1.00 17.95 ? 473 HOH A O   1 
HETATM 4151 O O   B HOH H 4 .   ? -12.175 -26.561 -13.409 0.85 20.73 ? 474 HOH A O   1 
HETATM 4152 O O   . HOH H 4 .   ? -13.855 -8.975  4.908   1.00 22.63 ? 475 HOH A O   1 
HETATM 4153 O O   . HOH H 4 .   ? -9.030  0.317   -19.044 1.00 13.78 ? 476 HOH A O   1 
HETATM 4154 O O   . HOH H 4 .   ? -10.685 4.148   -16.690 1.00 12.43 ? 477 HOH A O   1 
HETATM 4155 O O   . HOH H 4 .   ? -7.620  -26.598 -8.243  1.00 15.92 ? 478 HOH A O   1 
HETATM 4156 O O   . HOH H 4 .   ? -5.078  3.276   -31.670 1.00 21.15 ? 479 HOH A O   1 
HETATM 4157 O O   . HOH H 4 .   ? 1.845   -14.098 2.722   1.00 24.22 ? 480 HOH A O   1 
HETATM 4158 O O   . HOH H 4 .   ? -18.279 -20.924 -1.961  1.00 12.69 ? 481 HOH A O   1 
HETATM 4159 O O   . HOH H 4 .   ? 8.542   5.492   -0.542  1.00 16.41 ? 482 HOH A O   1 
HETATM 4160 O O   . HOH H 4 .   ? -4.635  -0.822  1.466   1.00 15.18 ? 483 HOH A O   1 
HETATM 4161 O O   . HOH H 4 .   ? -19.308 1.950   -7.571  1.00 21.93 ? 484 HOH A O   1 
HETATM 4162 O O   . HOH H 4 .   ? -7.778  -0.822  -10.432 1.00 14.46 ? 485 HOH A O   1 
HETATM 4163 O O   . HOH H 4 .   ? -13.849 -19.524 -23.843 1.00 10.77 ? 486 HOH A O   1 
HETATM 4164 O O   . HOH H 4 .   ? 4.765   3.650   -8.022  1.00 20.85 ? 487 HOH A O   1 
HETATM 4165 O O   . HOH H 4 .   ? -12.237 4.075   -3.146  1.00 11.89 ? 488 HOH A O   1 
HETATM 4166 O O   . HOH H 4 .   ? -7.199  5.740   -23.314 1.00 23.86 ? 489 HOH A O   1 
HETATM 4167 O O   . HOH H 4 .   ? -13.445 3.676   -10.903 1.00 11.70 ? 490 HOH A O   1 
HETATM 4168 O O   . HOH H 4 .   ? -7.866  0.637   -0.805  1.00 20.52 ? 491 HOH A O   1 
HETATM 4169 O O   . HOH H 4 .   ? -0.571  -2.713  8.333   1.00 21.89 ? 492 HOH A O   1 
HETATM 4170 O O   . HOH H 4 .   ? -7.092  -21.579 3.381   1.00 14.06 ? 493 HOH A O   1 
HETATM 4171 O O   . HOH H 4 .   ? -10.401 -22.156 2.176   1.00 12.68 ? 494 HOH A O   1 
HETATM 4172 O O   . HOH H 4 .   ? -7.045  3.209   -15.784 1.00 32.07 ? 495 HOH A O   1 
HETATM 4173 O O   . HOH H 4 .   ? -4.819  -0.242  -33.114 1.00 21.16 ? 496 HOH A O   1 
HETATM 4174 O O   . HOH H 4 .   ? -16.385 -25.874 -15.313 1.00 28.29 ? 497 HOH A O   1 
HETATM 4175 O O   . HOH H 4 .   ? -4.509  -1.993  -37.869 1.00 32.30 ? 498 HOH A O   1 
HETATM 4176 O O   . HOH H 4 .   ? -20.995 7.014   -16.654 1.00 19.06 ? 499 HOH A O   1 
HETATM 4177 O O   . HOH H 4 .   ? -19.553 -15.575 -20.365 1.00 14.68 ? 500 HOH A O   1 
HETATM 4178 O O   . HOH H 4 .   ? -4.559  1.024   -20.870 1.00 31.23 ? 501 HOH A O   1 
HETATM 4179 O O   . HOH H 4 .   ? -26.609 -5.700  -25.492 1.00 30.77 ? 502 HOH A O   1 
HETATM 4180 O O   . HOH H 4 .   ? -22.723 -11.445 -0.269  1.00 22.19 ? 503 HOH A O   1 
HETATM 4181 O O   . HOH H 4 .   ? -6.851  -14.964 -31.502 1.00 15.91 ? 504 HOH A O   1 
HETATM 4182 O O   . HOH H 4 .   ? -21.601 -18.940 -0.896  1.00 11.43 ? 505 HOH A O   1 
HETATM 4183 O O   . HOH H 4 .   ? -30.554 -2.419  -9.823  1.00 17.91 ? 506 HOH A O   1 
HETATM 4184 O O   . HOH H 4 .   ? -15.320 1.032   -15.683 1.00 11.02 ? 507 HOH A O   1 
HETATM 4185 O O   . HOH H 4 .   ? -25.441 -14.612 -28.116 1.00 21.28 ? 508 HOH A O   1 
HETATM 4186 O O   . HOH H 4 .   ? -8.181  -12.812 -34.186 1.00 15.72 ? 509 HOH A O   1 
HETATM 4187 O O   . HOH H 4 .   ? 12.534  -3.865  4.882   1.00 23.89 ? 510 HOH A O   1 
HETATM 4188 O O   . HOH H 4 .   ? -2.660  -21.343 2.767   1.00 18.18 ? 511 HOH A O   1 
HETATM 4189 O O   . HOH H 4 .   ? -16.104 -22.399 -4.661  1.00 14.68 ? 512 HOH A O   1 
HETATM 4190 O O   . HOH H 4 .   ? -15.414 0.877   -39.017 1.00 16.44 ? 513 HOH A O   1 
HETATM 4191 O O   . HOH H 4 .   ? 12.849  -2.478  -6.021  1.00 20.11 ? 514 HOH A O   1 
HETATM 4192 O O   . HOH H 4 .   ? -11.189 -3.204  -8.438  1.00 12.93 ? 515 HOH A O   1 
HETATM 4193 O O   . HOH H 4 .   ? -25.218 -15.564 -10.664 1.00 27.04 ? 516 HOH A O   1 
HETATM 4194 O O   . HOH H 4 .   ? -19.560 -1.775  0.887   1.00 26.66 ? 517 HOH A O   1 
HETATM 4195 O O   . HOH H 4 .   ? 7.304   -17.831 -18.184 1.00 23.05 ? 518 HOH A O   1 
HETATM 4196 O O   . HOH H 4 .   ? 2.586   -12.439 0.764   1.00 17.22 ? 519 HOH A O   1 
HETATM 4197 O O   . HOH H 4 .   ? -8.486  -11.101 -0.470  1.00 21.27 ? 520 HOH A O   1 
HETATM 4198 O O   . HOH H 4 .   ? 7.081   -10.487 2.051   1.00 25.25 ? 521 HOH A O   1 
HETATM 4199 O O   . HOH H 4 .   ? 6.523   -1.098  -21.279 1.00 35.61 ? 522 HOH A O   1 
HETATM 4200 O O   . HOH H 4 .   ? -5.307  -21.459 -2.387  1.00 30.30 ? 523 HOH A O   1 
HETATM 4201 O O   . HOH H 4 .   ? -11.495 -23.540 9.160   1.00 16.48 ? 524 HOH A O   1 
HETATM 4202 O O   . HOH H 4 .   ? -26.665 -12.599 -6.164  1.00 23.02 ? 525 HOH A O   1 
HETATM 4203 O O   . HOH H 4 .   ? -34.185 -12.084 -13.734 1.00 36.60 ? 526 HOH A O   1 
HETATM 4204 O O   . HOH H 4 .   ? -34.229 -7.476  -14.526 1.00 13.87 ? 527 HOH A O   1 
HETATM 4205 O O   . HOH H 4 .   ? -2.454  -21.891 -2.705  1.00 30.21 ? 528 HOH A O   1 
HETATM 4206 O O   . HOH H 4 .   ? -19.676 -3.948  -39.355 1.00 27.10 ? 529 HOH A O   1 
HETATM 4207 O O   . HOH H 4 .   ? 0.424   -16.949 5.358   1.00 24.88 ? 530 HOH A O   1 
HETATM 4208 O O   . HOH H 4 .   ? -34.086 -17.062 -19.951 1.00 32.97 ? 531 HOH A O   1 
HETATM 4209 O O   . HOH H 4 .   ? -25.768 0.931   -5.819  1.00 23.40 ? 532 HOH A O   1 
HETATM 4210 O O   . HOH H 4 .   ? -12.098 -29.312 -20.685 1.00 19.20 ? 533 HOH A O   1 
HETATM 4211 O O   . HOH H 4 .   ? -0.412  -21.693 -14.129 1.00 21.06 ? 534 HOH A O   1 
HETATM 4212 O O   . HOH H 4 .   ? -0.109  -22.053 -16.676 1.00 18.83 ? 535 HOH A O   1 
HETATM 4213 O O   . HOH H 4 .   ? -1.768  -24.605 -11.156 1.00 18.96 ? 536 HOH A O   1 
HETATM 4214 O O   . HOH H 4 .   ? 0.815   -22.767 -5.200  1.00 23.09 ? 537 HOH A O   1 
HETATM 4215 O O   . HOH H 4 .   ? -18.148 -8.372  3.544   1.00 16.61 ? 538 HOH A O   1 
HETATM 4216 O O   . HOH H 4 .   ? 9.205   -8.925  -9.977  1.00 17.67 ? 539 HOH A O   1 
HETATM 4217 O O   . HOH H 4 .   ? 12.010  -3.468  -9.529  1.00 23.34 ? 540 HOH A O   1 
HETATM 4218 O O   . HOH H 4 .   ? 5.791   -3.822  -32.512 1.00 20.54 ? 541 HOH A O   1 
HETATM 4219 O O   . HOH H 4 .   ? -8.178  4.190   -34.440 1.00 17.50 ? 542 HOH A O   1 
HETATM 4220 O O   . HOH H 4 .   ? -14.317 -23.547 -17.707 1.00 17.36 ? 543 HOH A O   1 
HETATM 4221 O O   . HOH H 4 .   ? 3.353   3.454   -25.378 1.00 27.29 ? 544 HOH A O   1 
HETATM 4222 O O   . HOH H 4 .   ? -24.725 -11.443 -30.996 1.00 23.76 ? 545 HOH A O   1 
HETATM 4223 O O   . HOH H 4 .   ? -6.819  -16.800 -29.210 1.00 18.74 ? 546 HOH A O   1 
HETATM 4224 O O   . HOH H 4 .   ? -25.284 -16.473 5.729   1.00 23.08 ? 547 HOH A O   1 
HETATM 4225 O O   . HOH H 4 .   ? -25.986 3.312   -25.003 1.00 25.65 ? 548 HOH A O   1 
HETATM 4226 O O   . HOH H 4 .   ? 5.177   -18.434 -2.467  1.00 26.68 ? 549 HOH A O   1 
HETATM 4227 O O   . HOH H 4 .   ? -5.933  -27.578 -15.582 1.00 27.21 ? 550 HOH A O   1 
HETATM 4228 O O   . HOH H 4 .   ? 6.336   -11.132 5.734   1.00 21.44 ? 551 HOH A O   1 
HETATM 4229 O O   . HOH H 4 .   ? -23.111 -21.571 -9.696  1.00 27.84 ? 552 HOH A O   1 
HETATM 4230 O O   . HOH H 4 .   ? 6.769   -17.152 -12.992 1.00 28.06 ? 553 HOH A O   1 
HETATM 4231 O O   . HOH H 4 .   ? -27.915 8.417   -15.847 1.00 33.62 ? 554 HOH A O   1 
HETATM 4232 O O   . HOH H 4 .   ? -19.152 -13.587 -31.899 1.00 30.32 ? 555 HOH A O   1 
HETATM 4233 O O   . HOH H 4 .   ? -21.123 -19.269 -22.643 1.00 16.78 ? 556 HOH A O   1 
HETATM 4234 O O   . HOH H 4 .   ? -14.528 0.224   -1.234  1.00 19.09 ? 557 HOH A O   1 
HETATM 4235 O O   . HOH H 4 .   ? 5.212   -12.919 -6.097  1.00 19.61 ? 558 HOH A O   1 
HETATM 4236 O O   . HOH H 4 .   ? -19.266 -15.688 -4.732  1.00 10.43 ? 559 HOH A O   1 
HETATM 4237 O O   . HOH H 4 .   ? -19.840 0.960   -34.042 1.00 21.63 ? 560 HOH A O   1 
HETATM 4238 O O   . HOH H 4 .   ? 5.704   -3.072  -36.869 1.00 27.26 ? 561 HOH A O   1 
HETATM 4239 O O   . HOH H 4 .   ? 7.078   -11.723 -1.235  1.00 26.83 ? 562 HOH A O   1 
HETATM 4240 O O   . HOH H 4 .   ? -16.146 -22.074 -25.737 1.00 18.34 ? 563 HOH A O   1 
HETATM 4241 O O   . HOH H 4 .   ? -7.621  -20.235 -2.715  1.00 15.80 ? 564 HOH A O   1 
HETATM 4242 O O   . HOH H 4 .   ? -3.264  -22.325 -22.652 1.00 23.42 ? 565 HOH A O   1 
HETATM 4243 O O   . HOH H 4 .   ? -9.416  -13.019 7.766   1.00 17.10 ? 566 HOH A O   1 
HETATM 4244 O O   . HOH H 4 .   ? -14.085 -3.133  2.794   1.00 21.05 ? 567 HOH A O   1 
HETATM 4245 O O   . HOH H 4 .   ? -22.034 4.361   -15.436 1.00 24.94 ? 568 HOH A O   1 
HETATM 4246 O O   . HOH H 4 .   ? -1.323  -0.508  4.939   1.00 26.38 ? 569 HOH A O   1 
HETATM 4247 O O   B HOH H 4 .   ? -0.674  4.061   -30.866 0.94 21.19 ? 570 HOH A O   1 
HETATM 4248 O O   . HOH H 4 .   ? -31.771 -0.096  -9.489  1.00 31.65 ? 571 HOH A O   1 
HETATM 4249 O O   . HOH H 4 .   ? 3.481   -21.229 -21.950 1.00 29.97 ? 572 HOH A O   1 
HETATM 4250 O O   . HOH H 4 .   ? -12.631 -15.761 14.423  1.00 24.77 ? 573 HOH A O   1 
HETATM 4251 O O   . HOH H 4 .   ? -25.633 -7.018  -36.663 1.00 25.32 ? 574 HOH A O   1 
HETATM 4252 O O   . HOH H 4 .   ? -36.568 -2.710  -15.834 1.00 22.86 ? 575 HOH A O   1 
HETATM 4253 O O   . HOH H 4 .   ? -5.563  3.077   -34.505 1.00 18.61 ? 576 HOH A O   1 
HETATM 4254 O O   . HOH H 4 .   ? -2.528  -10.559 -28.575 1.00 19.65 ? 577 HOH A O   1 
HETATM 4255 O O   . HOH H 4 .   ? 4.276   -3.231  -17.766 1.00 24.28 ? 578 HOH A O   1 
HETATM 4256 O O   . HOH H 4 .   ? -13.826 -23.870 -4.819  1.00 16.43 ? 579 HOH A O   1 
HETATM 4257 O O   . HOH H 4 .   ? -10.649 -3.398  2.973   1.00 26.40 ? 580 HOH A O   1 
HETATM 4258 O O   . HOH H 4 .   ? 6.036   -5.239  -18.287 1.00 25.59 ? 581 HOH A O   1 
HETATM 4259 O O   . HOH H 4 .   ? -3.097  0.206   -34.954 1.00 34.04 ? 582 HOH A O   1 
HETATM 4260 O O   . HOH H 4 .   ? 3.251   -12.191 9.900   1.00 26.96 ? 583 HOH A O   1 
HETATM 4261 O O   B HOH H 4 .   ? 3.224   6.716   -3.405  1.00 27.85 ? 584 HOH A O   1 
HETATM 4262 O O   . HOH H 4 .   ? 13.022  -9.391  7.795   1.00 34.72 ? 585 HOH A O   1 
HETATM 4263 O O   . HOH H 4 .   ? -1.108  -19.150 4.667   1.00 16.68 ? 586 HOH A O   1 
HETATM 4264 O O   . HOH H 4 .   ? -20.880 -14.070 -22.290 1.00 12.23 ? 587 HOH A O   1 
HETATM 4265 O O   . HOH H 4 .   ? -6.217  -7.899  -23.886 1.00 19.03 ? 588 HOH A O   1 
HETATM 4266 O O   . HOH H 4 .   ? -17.438 -14.900 -30.099 1.00 14.19 ? 589 HOH A O   1 
HETATM 4267 O O   . HOH H 4 .   ? -5.008  -22.424 -19.031 1.00 24.52 ? 590 HOH A O   1 
HETATM 4268 O O   . HOH H 4 .   ? -16.883 -13.401 -32.678 1.00 23.51 ? 591 HOH A O   1 
HETATM 4269 O O   . HOH H 4 .   ? -1.724  6.425   -7.865  1.00 24.26 ? 592 HOH A O   1 
HETATM 4270 O O   . HOH H 4 .   ? -5.993  -17.807 10.338  1.00 20.92 ? 593 HOH A O   1 
HETATM 4271 O O   . HOH H 4 .   ? -20.891 -5.499  -0.932  1.00 20.53 ? 594 HOH A O   1 
HETATM 4272 O O   . HOH H 4 .   ? -15.921 6.281   -26.208 1.00 17.01 ? 595 HOH A O   1 
HETATM 4273 O O   . HOH H 4 .   ? -8.707  -7.733  -35.260 1.00 22.29 ? 596 HOH A O   1 
HETATM 4274 O O   . HOH H 4 .   ? -28.181 -7.624  -32.780 1.00 32.82 ? 597 HOH A O   1 
HETATM 4275 O O   . HOH H 4 .   ? -3.601  -9.184  -31.327 1.00 22.02 ? 598 HOH A O   1 
HETATM 4276 O O   A HOH H 4 .   ? -11.341 -11.873 -37.933 0.43 23.08 ? 599 HOH A O   1 
HETATM 4277 O O   B HOH H 4 .   ? -12.611 -14.128 -38.441 0.57 18.65 ? 599 HOH A O   1 
HETATM 4278 O O   . HOH H 4 .   ? -10.410 3.219   -1.128  1.00 36.25 ? 600 HOH A O   1 
HETATM 4279 O O   . HOH H 4 .   ? -18.080 -5.983  2.440   1.00 18.64 ? 601 HOH A O   1 
HETATM 4280 O O   . HOH H 4 .   ? 4.490   -1.321  9.517   1.00 27.78 ? 602 HOH A O   1 
HETATM 4281 O O   . HOH H 4 .   ? -8.729  -20.508 11.305  1.00 23.57 ? 603 HOH A O   1 
HETATM 4282 O O   . HOH H 4 .   ? -11.685 3.898   -33.205 1.00 21.02 ? 604 HOH A O   1 
HETATM 4283 O O   A HOH H 4 .   ? -3.012  -20.083 9.189   0.61 18.78 ? 605 HOH A O   1 
HETATM 4284 O O   B HOH H 4 .   ? -3.647  -20.908 10.975  0.39 15.55 ? 605 HOH A O   1 
HETATM 4285 O O   . HOH H 4 .   ? -4.318  -6.219  -32.569 1.00 23.34 ? 606 HOH A O   1 
HETATM 4286 O O   . HOH H 4 .   ? -23.347 -13.097 -29.277 1.00 17.34 ? 607 HOH A O   1 
HETATM 4287 O O   . HOH H 4 .   ? -11.837 -4.773  4.749   1.00 35.34 ? 608 HOH A O   1 
HETATM 4288 O O   . HOH H 4 .   ? 3.824   -5.765  11.889  1.00 29.81 ? 609 HOH A O   1 
HETATM 4289 O O   . HOH H 4 .   ? 8.660   -12.889 -19.328 1.00 19.89 ? 610 HOH A O   1 
HETATM 4290 O O   . HOH H 4 .   ? -20.283 3.295   -29.188 1.00 22.67 ? 611 HOH A O   1 
HETATM 4291 O O   . HOH H 4 .   ? 13.116  0.751   -3.495  1.00 21.14 ? 612 HOH A O   1 
HETATM 4292 O O   . HOH H 4 .   ? 7.357   -14.640 -13.112 1.00 18.74 ? 613 HOH A O   1 
HETATM 4293 O O   . HOH H 4 .   ? -26.097 9.504   -18.034 1.00 25.58 ? 614 HOH A O   1 
HETATM 4294 O O   . HOH H 4 .   ? -27.898 -15.074 -25.902 1.00 21.03 ? 615 HOH A O   1 
HETATM 4295 O O   . HOH H 4 .   ? -6.459  0.756   -18.753 1.00 26.11 ? 616 HOH A O   1 
HETATM 4296 O O   . HOH H 4 .   ? 6.766   1.245   7.000   1.00 26.94 ? 617 HOH A O   1 
HETATM 4297 O O   . HOH H 4 .   ? -35.687 -10.409 -19.980 1.00 23.51 ? 618 HOH A O   1 
HETATM 4298 O O   . HOH H 4 .   ? 0.749   2.806   -23.808 1.00 27.53 ? 619 HOH A O   1 
HETATM 4299 O O   . HOH H 4 .   ? -31.059 -19.850 -18.899 1.00 28.12 ? 620 HOH A O   1 
HETATM 4300 O O   . HOH H 4 .   ? 1.548   -23.464 -23.078 1.00 33.58 ? 621 HOH A O   1 
HETATM 4301 O O   . HOH H 4 .   ? -4.455  6.005   -0.932  1.00 25.30 ? 622 HOH A O   1 
HETATM 4302 O O   . HOH H 4 .   ? -14.540 -16.412 -30.622 1.00 15.33 ? 623 HOH A O   1 
HETATM 4303 O O   . HOH H 4 .   ? -2.430  2.952   2.700   1.00 31.86 ? 624 HOH A O   1 
HETATM 4304 O O   . HOH H 4 .   ? 6.028   -19.237 -16.489 1.00 35.29 ? 625 HOH A O   1 
HETATM 4305 O O   . HOH H 4 .   ? 15.286  -4.751  0.446   1.00 19.23 ? 626 HOH A O   1 
HETATM 4306 O O   . HOH H 4 .   ? 13.738  -8.618  -5.531  1.00 27.35 ? 627 HOH A O   1 
HETATM 4307 O O   . HOH H 4 .   ? 7.476   -9.258  -3.557  1.00 23.19 ? 628 HOH A O   1 
HETATM 4308 O O   . HOH H 4 .   ? -34.897 -6.633  -17.086 1.00 27.22 ? 629 HOH A O   1 
HETATM 4309 O O   B HOH H 4 .   ? -7.922  -7.772  8.354   1.00 22.58 ? 630 HOH A O   1 
HETATM 4310 O O   . HOH H 4 .   ? -0.277  -25.128 -8.576  1.00 34.03 ? 631 HOH A O   1 
HETATM 4311 O O   . HOH H 4 .   ? -8.066  -3.289  3.856   1.00 26.01 ? 632 HOH A O   1 
HETATM 4312 O O   . HOH H 4 .   ? -2.744  -12.452 -26.762 1.00 19.89 ? 633 HOH A O   1 
HETATM 4313 O O   . HOH H 4 .   ? -35.945 -10.496 -23.158 1.00 28.79 ? 634 HOH A O   1 
HETATM 4314 O O   . HOH H 4 .   ? -10.533 7.769   -23.412 1.00 25.68 ? 635 HOH A O   1 
HETATM 4315 O O   . HOH H 4 .   ? 5.654   -4.536  -35.054 1.00 31.17 ? 636 HOH A O   1 
HETATM 4316 O O   . HOH H 4 .   ? -21.471 -14.640 -31.052 1.00 22.46 ? 637 HOH A O   1 
HETATM 4317 O O   . HOH H 4 .   ? 0.023   -3.442  -38.474 1.00 29.99 ? 638 HOH A O   1 
HETATM 4318 O O   . HOH H 4 .   ? -22.641 -9.616  -2.346  1.00 20.06 ? 639 HOH A O   1 
HETATM 4319 O O   . HOH H 4 .   ? -34.066 -7.926  -11.074 1.00 27.48 ? 640 HOH A O   1 
HETATM 4320 O O   . HOH H 4 .   ? -35.056 -8.293  -19.807 1.00 29.72 ? 641 HOH A O   1 
HETATM 4321 O O   . HOH H 4 .   ? -2.800  0.540   3.235   1.00 22.58 ? 642 HOH A O   1 
HETATM 4322 O O   . HOH H 4 .   ? 6.579   -1.242  -17.110 1.00 27.83 ? 643 HOH A O   1 
HETATM 4323 O O   . HOH H 4 .   ? -17.176 -3.513  -39.958 1.00 27.07 ? 644 HOH A O   1 
HETATM 4324 O O   . HOH H 4 .   ? -14.943 -26.385 -4.653  1.00 20.52 ? 645 HOH A O   1 
HETATM 4325 O O   . HOH H 4 .   ? -17.071 -19.884 -20.009 1.00 20.32 ? 646 HOH A O   1 
HETATM 4326 O O   . HOH H 4 .   ? -4.593  7.742   -17.843 1.00 29.29 ? 647 HOH A O   1 
HETATM 4327 O O   . HOH H 4 .   ? -3.691  -11.433 -33.043 1.00 26.00 ? 648 HOH A O   1 
HETATM 4328 O O   . HOH H 4 .   ? -8.048  -10.253 -35.329 1.00 18.08 ? 649 HOH A O   1 
HETATM 4329 O O   . HOH H 4 .   ? -23.822 -17.310 -19.363 1.00 27.40 ? 650 HOH A O   1 
HETATM 4330 O O   . HOH H 4 .   ? -7.666  -23.322 -4.824  1.00 18.46 ? 651 HOH A O   1 
HETATM 4331 O O   . HOH H 4 .   ? -16.289 -4.240  4.102   1.00 31.35 ? 652 HOH A O   1 
HETATM 4332 O O   . HOH H 4 .   ? 2.076   -24.683 -20.407 1.00 33.46 ? 653 HOH A O   1 
HETATM 4333 O O   . HOH H 4 .   ? 15.059  -4.163  -6.963  1.00 27.74 ? 654 HOH A O   1 
HETATM 4334 O O   . HOH H 4 .   ? -5.226  0.729   -0.588  1.00 13.70 ? 655 HOH A O   1 
HETATM 4335 O O   . HOH H 4 .   ? -4.284  -25.646 -11.769 1.00 25.67 ? 656 HOH A O   1 
HETATM 4336 O O   . HOH H 4 .   ? -15.290 7.680   -28.616 1.00 27.77 ? 657 HOH A O   1 
HETATM 4337 O O   A HOH H 4 .   ? -12.548 -21.852 -24.210 0.54 14.18 ? 658 HOH A O   1 
HETATM 4338 O O   B HOH H 4 .   ? -10.288 -22.646 -23.200 0.46 10.22 ? 658 HOH A O   1 
HETATM 4339 O O   . HOH H 4 .   ? -14.308 -11.139 3.761   1.00 27.21 ? 659 HOH A O   1 
HETATM 4340 O O   . HOH H 4 .   ? -2.307  -23.430 -18.137 1.00 19.63 ? 660 HOH A O   1 
HETATM 4341 O O   . HOH H 4 .   ? -30.193 -5.804  -8.926  1.00 25.52 ? 661 HOH A O   1 
HETATM 4342 O O   . HOH H 4 .   ? -4.342  -13.872 -31.203 1.00 19.53 ? 662 HOH A O   1 
HETATM 4343 O O   . HOH H 4 .   ? -11.532 -31.824 -19.481 1.00 34.07 ? 663 HOH A O   1 
HETATM 4344 O O   . HOH H 4 .   ? -19.786 -16.300 -30.118 1.00 24.80 ? 664 HOH A O   1 
HETATM 4345 O O   . HOH H 4 .   ? 1.608   -23.897 -17.353 1.00 30.48 ? 665 HOH A O   1 
HETATM 4346 O O   . HOH H 4 .   ? -0.602  -25.306 -19.885 1.00 26.71 ? 666 HOH A O   1 
HETATM 4347 O O   . HOH H 4 .   ? -14.532 -27.616 -13.819 1.00 28.50 ? 667 HOH A O   1 
HETATM 4348 O O   . HOH H 4 .   ? -10.803 -5.211  -38.175 1.00 21.37 ? 668 HOH A O   1 
HETATM 4349 O O   . HOH H 4 .   ? 16.836  -2.204  -2.915  1.00 24.38 ? 669 HOH A O   1 
HETATM 4350 O O   . HOH H 4 .   ? -10.419 -8.503  13.591  1.00 24.79 ? 670 HOH A O   1 
HETATM 4351 O O   . HOH H 4 .   ? -16.567 -7.935  5.724   1.00 22.66 ? 671 HOH A O   1 
HETATM 4352 O O   . HOH H 4 .   ? -30.206 -8.247  -35.255 1.00 31.54 ? 672 HOH A O   1 
HETATM 4353 O O   . HOH H 4 .   ? 8.374   -8.187  -24.014 1.00 20.82 ? 673 HOH A O   1 
HETATM 4354 O O   . HOH H 4 .   ? 9.662   -8.435  -7.303  1.00 23.76 ? 674 HOH A O   1 
HETATM 4355 O O   . HOH H 4 .   ? -4.861  3.388   0.306   1.00 19.54 ? 675 HOH A O   1 
HETATM 4356 O O   . HOH H 4 .   ? -6.109  -20.235 11.277  1.00 29.01 ? 676 HOH A O   1 
HETATM 4357 O O   . HOH H 4 .   ? -13.511 -0.324  0.980   1.00 34.79 ? 677 HOH A O   1 
HETATM 4358 O O   . HOH H 4 .   ? -28.997 -1.350  -8.385  1.00 35.92 ? 678 HOH A O   1 
HETATM 4359 O O   . HOH H 4 .   ? -15.428 -20.732 -21.830 1.00 15.52 ? 679 HOH A O   1 
HETATM 4360 O O   . HOH H 4 .   ? -32.597 -6.933  -9.328  1.00 35.57 ? 680 HOH A O   1 
HETATM 4361 O O   . HOH H 4 .   ? 5.360   -15.737 -6.519  1.00 15.73 ? 681 HOH A O   1 
HETATM 4362 O O   . HOH H 4 .   ? -7.793  -3.623  6.547   1.00 25.95 ? 682 HOH A O   1 
HETATM 4363 O O   . HOH H 4 .   ? -11.975 -12.365 7.150   1.00 27.87 ? 683 HOH A O   1 
HETATM 4364 O O   . HOH H 4 .   ? -19.873 -19.721 -20.318 1.00 21.60 ? 684 HOH A O   1 
HETATM 4365 O O   . HOH H 4 .   ? -26.475 -18.939 -7.609  1.00 24.39 ? 685 HOH A O   1 
HETATM 4366 O O   . HOH H 4 .   ? -8.692  0.450   1.776   1.00 25.74 ? 686 HOH A O   1 
HETATM 4367 O O   . HOH H 4 .   ? 7.382   -12.119 -6.611  1.00 31.19 ? 687 HOH A O   1 
HETATM 4368 O O   . HOH H 4 .   ? -15.913 -20.943 -17.963 1.00 26.35 ? 688 HOH A O   1 
HETATM 4369 O O   . HOH H 4 .   ? 6.485   -17.377 -4.378  1.00 21.69 ? 689 HOH A O   1 
HETATM 4370 O O   . HOH H 4 .   ? 15.668  -4.201  3.044   1.00 31.10 ? 690 HOH A O   1 
HETATM 4371 O O   . HOH H 4 .   ? -26.090 -10.078 -5.503  1.00 28.50 ? 691 HOH A O   1 
HETATM 4372 O O   . HOH H 4 .   ? -5.713  -27.373 -9.945  1.00 27.04 ? 692 HOH A O   1 
HETATM 4373 O O   . HOH H 4 .   ? -30.383 -19.418 -21.621 1.00 29.94 ? 693 HOH A O   1 
HETATM 4374 O O   . HOH H 4 .   ? -7.235  3.323   1.649   1.00 32.44 ? 694 HOH A O   1 
HETATM 4375 O O   . HOH H 4 .   ? -9.271  0.261   -41.942 1.00 27.14 ? 695 HOH A O   1 
HETATM 4376 O O   . HOH H 4 .   ? -11.929 -7.872  11.031  1.00 32.56 ? 696 HOH A O   1 
HETATM 4377 O O   . HOH H 4 .   ? -12.838 -17.663 15.678  1.00 31.00 ? 697 HOH A O   1 
HETATM 4378 O O   B HOH H 4 .   ? -9.983  -28.803 -13.176 0.99 28.74 ? 698 HOH A O   1 
HETATM 4379 O O   . HOH H 4 .   ? 5.320   -12.738 0.935   1.00 25.12 ? 699 HOH A O   1 
HETATM 4380 O O   . HOH H 4 .   ? -18.522 2.610   -31.720 1.00 27.05 ? 700 HOH A O   1 
HETATM 4381 O O   . HOH H 4 .   ? -15.095 -28.285 -11.043 1.00 34.78 ? 701 HOH A O   1 
HETATM 4382 O O   . HOH H 4 .   ? -6.798  0.545   5.222   1.00 31.41 ? 702 HOH A O   1 
HETATM 4383 O O   . HOH H 4 .   ? 11.540  -9.773  -6.191  1.00 31.28 ? 703 HOH A O   1 
HETATM 4384 O O   . HOH H 4 .   ? -35.780 -6.441  -21.614 1.00 26.26 ? 704 HOH A O   1 
HETATM 4385 O O   . HOH H 4 .   ? -14.496 7.661   -24.174 1.00 23.50 ? 705 HOH A O   1 
HETATM 4386 O O   . HOH H 4 .   ? 0.598   -21.736 -27.728 1.00 33.22 ? 706 HOH A O   1 
HETATM 4387 O O   . HOH H 4 .   ? -20.660 -8.658  4.834   1.00 21.90 ? 707 HOH A O   1 
HETATM 4388 O O   . HOH H 4 .   ? -6.894  -0.818  3.017   1.00 18.98 ? 708 HOH A O   1 
HETATM 4389 O O   . HOH H 4 .   ? -2.999  -24.384 -4.863  1.00 26.25 ? 709 HOH A O   1 
HETATM 4390 O O   . HOH H 4 .   ? 10.343  -9.789  -13.015 1.00 15.93 ? 710 HOH A O   1 
HETATM 4391 O O   . HOH H 4 .   ? -0.954  -24.416 -13.458 1.00 31.13 ? 711 HOH A O   1 
HETATM 4392 O O   . HOH H 4 .   ? -0.451  -5.428  11.391  1.00 26.50 ? 712 HOH A O   1 
HETATM 4393 O O   . HOH H 4 .   ? -5.329  -12.674 -34.517 1.00 31.87 ? 713 HOH A O   1 
HETATM 4394 O O   . HOH H 4 .   ? -12.403 2.736   1.245   1.00 26.18 ? 714 HOH A O   1 
HETATM 4395 O O   . HOH H 4 .   ? 7.031   -17.750 -10.707 1.00 29.74 ? 715 HOH A O   1 
HETATM 4396 O O   . HOH H 4 .   ? -22.824 -6.969  -1.774  1.00 23.46 ? 716 HOH A O   1 
HETATM 4397 O O   . HOH H 4 .   ? -0.911  -23.239 -25.939 1.00 30.00 ? 717 HOH A O   1 
HETATM 4398 O O   . HOH H 4 .   ? -4.051  -17.045 -28.963 1.00 28.78 ? 718 HOH A O   1 
HETATM 4399 O O   . HOH H 4 .   ? -12.390 -9.395  7.008   1.00 29.46 ? 719 HOH A O   1 
HETATM 4400 O O   . HOH H 4 .   ? -17.962 -0.285  2.673   1.00 24.96 ? 720 HOH A O   1 
HETATM 4401 O O   . HOH H 4 .   ? -6.619  -28.771 -12.387 1.00 33.10 ? 721 HOH A O   1 
HETATM 4402 O O   . HOH H 4 .   ? 15.871  -7.368  0.073   1.00 23.45 ? 722 HOH A O   1 
HETATM 4403 O O   . HOH H 4 .   ? 9.153   -14.866 -8.029  1.00 36.07 ? 723 HOH A O   1 
HETATM 4404 O O   . HOH H 4 .   ? 3.034   -21.350 -27.049 1.00 26.64 ? 724 HOH A O   1 
HETATM 4405 O O   . HOH H 4 .   ? 6.999   -16.651 -8.347  1.00 22.04 ? 725 HOH A O   1 
HETATM 4406 O O   . HOH H 4 .   ? -11.776 -23.925 -2.970  1.00 22.13 ? 726 HOH A O   1 
HETATM 4407 O O   . HOH H 4 .   ? -9.200  -22.576 -2.726  1.00 20.47 ? 727 HOH A O   1 
HETATM 4408 O O   . HOH H 4 .   ? -10.457 -26.515 -3.617  1.00 25.30 ? 728 HOH A O   1 
HETATM 4409 O O   . HOH H 4 .   ? -10.642 2.646   3.920   1.00 41.95 ? 729 HOH A O   1 
HETATM 4410 O O   . HOH I 4 .   ? -20.852 7.462   -8.157  1.00 23.87 ? 401 HOH B O   1 
HETATM 4411 O O   . HOH I 4 .   ? 6.775   25.227  -11.845 1.00 34.68 ? 402 HOH B O   1 
HETATM 4412 O O   . HOH I 4 .   ? -37.087 8.380   12.366  1.00 33.03 ? 403 HOH B O   1 
HETATM 4413 O O   . HOH I 4 .   ? -1.739  6.278   -12.376 1.00 23.47 ? 404 HOH B O   1 
HETATM 4414 O O   . HOH I 4 .   ? -25.651 16.761  11.373  1.00 21.01 ? 405 HOH B O   1 
HETATM 4415 O O   . HOH I 4 .   ? -32.807 9.472   -6.601  1.00 31.76 ? 406 HOH B O   1 
HETATM 4416 O O   . HOH I 4 .   ? -11.203 35.640  3.886   1.00 20.42 ? 407 HOH B O   1 
HETATM 4417 O O   . HOH I 4 .   ? -31.397 28.540  -18.516 1.00 31.47 ? 408 HOH B O   1 
HETATM 4418 O O   . HOH I 4 .   ? -23.210 18.761  -6.996  1.00 13.94 ? 409 HOH B O   1 
HETATM 4419 O O   . HOH I 4 .   ? -14.252 37.462  5.441   1.00 29.51 ? 410 HOH B O   1 
HETATM 4420 O O   . HOH I 4 .   ? -14.418 40.342  0.390   1.00 31.72 ? 411 HOH B O   1 
HETATM 4421 O O   . HOH I 4 .   ? -22.946 2.326   3.001   1.00 22.01 ? 412 HOH B O   1 
HETATM 4422 O O   . HOH I 4 .   ? -0.714  38.897  -23.549 1.00 30.67 ? 413 HOH B O   1 
HETATM 4423 O O   . HOH I 4 .   ? -22.899 1.598   6.716   1.00 19.81 ? 414 HOH B O   1 
HETATM 4424 O O   . HOH I 4 .   ? -12.676 26.258  -33.976 1.00 31.09 ? 415 HOH B O   1 
HETATM 4425 O O   . HOH I 4 .   ? -10.138 36.218  -18.347 1.00 17.01 ? 416 HOH B O   1 
HETATM 4426 O O   . HOH I 4 .   ? -7.803  25.626  -31.919 1.00 26.50 ? 417 HOH B O   1 
HETATM 4427 O O   . HOH I 4 .   ? -26.391 37.479  -4.529  1.00 12.61 ? 418 HOH B O   1 
HETATM 4428 O O   . HOH I 4 .   ? -9.367  23.658  15.742  1.00 25.18 ? 419 HOH B O   1 
HETATM 4429 O O   . HOH I 4 .   ? 2.444   19.931  2.916   1.00 24.64 ? 420 HOH B O   1 
HETATM 4430 O O   . HOH I 4 .   ? -27.761 2.192   -4.437  1.00 13.20 ? 421 HOH B O   1 
HETATM 4431 O O   . HOH I 4 .   ? -29.776 24.751  -15.933 1.00 12.51 ? 422 HOH B O   1 
HETATM 4432 O O   . HOH I 4 .   ? -13.028 28.597  -4.031  1.00 14.20 ? 423 HOH B O   1 
HETATM 4433 O O   . HOH I 4 .   ? -5.514  5.466   -8.104  1.00 16.46 ? 424 HOH B O   1 
HETATM 4434 O O   . HOH I 4 .   ? -15.754 2.402   -0.967  1.00 21.00 ? 425 HOH B O   1 
HETATM 4435 O O   . HOH I 4 .   ? -21.680 -1.257  1.585   1.00 33.40 ? 426 HOH B O   1 
HETATM 4436 O O   . HOH I 4 .   ? -33.158 24.828  -22.786 1.00 34.80 ? 427 HOH B O   1 
HETATM 4437 O O   . HOH I 4 .   ? -28.735 35.612  -6.068  1.00 17.05 ? 428 HOH B O   1 
HETATM 4438 O O   . HOH I 4 .   ? -0.308  29.173  -2.849  1.00 21.87 ? 429 HOH B O   1 
HETATM 4439 O O   . HOH I 4 .   ? -23.708 0.263   -4.295  1.00 18.05 ? 430 HOH B O   1 
HETATM 4440 O O   . HOH I 4 .   ? -28.920 27.911  9.734   1.00 22.17 ? 431 HOH B O   1 
HETATM 4441 O O   . HOH I 4 .   ? 2.174   20.600  -24.661 1.00 21.03 ? 432 HOH B O   1 
HETATM 4442 O O   . HOH I 4 .   ? -2.552  20.577  8.736   1.00 24.31 ? 433 HOH B O   1 
HETATM 4443 O O   . HOH I 4 .   ? -7.304  7.337   -17.241 1.00 27.39 ? 434 HOH B O   1 
HETATM 4444 O O   . HOH I 4 .   ? 4.710   26.668  -12.542 1.00 37.85 ? 435 HOH B O   1 
HETATM 4445 O O   . HOH I 4 .   ? -11.529 14.689  12.920  1.00 17.31 ? 436 HOH B O   1 
HETATM 4446 O O   . HOH I 4 .   ? -29.974 28.700  -22.169 1.00 23.72 ? 437 HOH B O   1 
HETATM 4447 O O   . HOH I 4 .   ? -9.737  17.469  -25.681 1.00 17.93 ? 438 HOH B O   1 
HETATM 4448 O O   . HOH I 4 .   ? -3.531  29.982  -28.984 1.00 26.08 ? 439 HOH B O   1 
HETATM 4449 O O   . HOH I 4 .   ? -14.661 22.793  -2.996  1.00 19.23 ? 440 HOH B O   1 
HETATM 4450 O O   . HOH I 4 .   ? -31.278 14.368  8.752   1.00 25.97 ? 441 HOH B O   1 
HETATM 4451 O O   . HOH I 4 .   ? -23.148 30.040  -13.363 1.00 13.75 ? 442 HOH B O   1 
HETATM 4452 O O   . HOH I 4 .   ? -14.788 15.767  -14.649 1.00 11.92 ? 443 HOH B O   1 
HETATM 4453 O O   . HOH I 4 .   ? -24.664 17.790  -18.241 1.00 8.81  ? 444 HOH B O   1 
HETATM 4454 O O   A HOH I 4 .   ? -21.840 13.713  18.629  0.49 16.55 ? 445 HOH B O   1 
HETATM 4455 O O   B HOH I 4 .   ? -20.355 14.507  19.616  0.51 21.18 ? 445 HOH B O   1 
HETATM 4456 O O   . HOH I 4 .   ? -2.845  8.845   -16.199 1.00 14.29 ? 446 HOH B O   1 
HETATM 4457 O O   . HOH I 4 .   ? -37.059 11.792  -2.381  1.00 25.48 ? 447 HOH B O   1 
HETATM 4458 O O   . HOH I 4 .   ? -32.800 21.024  -0.377  1.00 18.04 ? 448 HOH B O   1 
HETATM 4459 O O   . HOH I 4 .   ? 5.703   12.536  -5.458  1.00 26.73 ? 449 HOH B O   1 
HETATM 4460 O O   . HOH I 4 .   ? -17.795 29.561  -26.773 1.00 33.05 ? 450 HOH B O   1 
HETATM 4461 O O   . HOH I 4 .   ? -26.982 32.519  -0.733  1.00 12.04 ? 451 HOH B O   1 
HETATM 4462 O O   . HOH I 4 .   ? -26.983 28.618  -12.132 1.00 9.87  ? 452 HOH B O   1 
HETATM 4463 O O   . HOH I 4 .   ? -27.399 18.086  -17.367 1.00 28.14 ? 453 HOH B O   1 
HETATM 4464 O O   . HOH I 4 .   ? -24.422 28.932  -11.230 1.00 15.22 ? 454 HOH B O   1 
HETATM 4465 O O   . HOH I 4 .   ? 6.762   20.167  -8.444  1.00 17.26 ? 455 HOH B O   1 
HETATM 4466 O O   . HOH I 4 .   ? -10.458 34.508  -2.621  1.00 27.37 ? 456 HOH B O   1 
HETATM 4467 O O   . HOH I 4 .   ? -33.910 7.128   9.689   1.00 24.96 ? 457 HOH B O   1 
HETATM 4468 O O   . HOH I 4 .   ? -24.872 18.294  14.820  1.00 23.22 ? 458 HOH B O   1 
HETATM 4469 O O   . HOH I 4 .   ? -25.341 -2.863  -2.591  1.00 26.92 ? 459 HOH B O   1 
HETATM 4470 O O   . HOH I 4 .   ? -15.915 38.481  -0.634  1.00 19.90 ? 460 HOH B O   1 
HETATM 4471 O O   . HOH I 4 .   ? -2.747  8.575   -11.547 1.00 28.04 ? 461 HOH B O   1 
HETATM 4472 O O   . HOH I 4 .   ? -16.624 5.818   0.595   1.00 15.59 ? 462 HOH B O   1 
HETATM 4473 O O   . HOH I 4 .   ? -22.356 25.078  -9.012  1.00 14.07 ? 463 HOH B O   1 
HETATM 4474 O O   . HOH I 4 .   ? 4.972   14.994  -4.581  1.00 24.70 ? 464 HOH B O   1 
HETATM 4475 O O   . HOH I 4 .   ? -33.868 1.383   10.145  1.00 33.60 ? 465 HOH B O   1 
HETATM 4476 O O   . HOH I 4 .   ? -33.208 19.265  -2.549  1.00 15.71 ? 466 HOH B O   1 
HETATM 4477 O O   . HOH I 4 .   ? -23.559 31.708  1.071   1.00 14.06 ? 467 HOH B O   1 
HETATM 4478 O O   . HOH I 4 .   ? -22.401 17.777  17.398  1.00 16.12 ? 468 HOH B O   1 
HETATM 4479 O O   . HOH I 4 .   ? -25.217 26.374  -10.588 1.00 12.31 ? 469 HOH B O   1 
HETATM 4480 O O   . HOH I 4 .   ? 1.047   13.918  -19.347 1.00 23.61 ? 470 HOH B O   1 
HETATM 4481 O O   . HOH I 4 .   ? -9.911  30.487  -26.927 1.00 17.29 ? 471 HOH B O   1 
HETATM 4482 O O   . HOH I 4 .   ? -29.012 7.594   -7.213  1.00 20.66 ? 472 HOH B O   1 
HETATM 4483 O O   . HOH I 4 .   ? -29.256 9.419   -11.220 1.00 23.85 ? 473 HOH B O   1 
HETATM 4484 O O   . HOH I 4 .   ? -17.502 14.675  20.163  1.00 18.98 ? 474 HOH B O   1 
HETATM 4485 O O   . HOH I 4 .   ? -31.697 22.238  -4.423  1.00 11.90 ? 475 HOH B O   1 
HETATM 4486 O O   . HOH I 4 .   ? -10.897 11.415  -20.965 1.00 15.22 ? 476 HOH B O   1 
HETATM 4487 O O   . HOH I 4 .   ? -40.231 6.461   5.565   1.00 32.12 ? 477 HOH B O   1 
HETATM 4488 O O   . HOH I 4 .   ? -10.104 35.059  -8.209  1.00 15.76 ? 478 HOH B O   1 
HETATM 4489 O O   . HOH I 4 .   ? -6.919  9.111   -8.968  1.00 19.71 ? 479 HOH B O   1 
HETATM 4490 O O   . HOH I 4 .   ? -8.245  18.620  17.446  1.00 19.99 ? 480 HOH B O   1 
HETATM 4491 O O   . HOH I 4 .   ? -27.210 42.243  -9.407  1.00 30.45 ? 481 HOH B O   1 
HETATM 4492 O O   . HOH I 4 .   ? -17.448 7.634   -15.809 1.00 22.95 ? 482 HOH B O   1 
HETATM 4493 O O   . HOH I 4 .   ? -17.145 21.806  16.757  1.00 14.83 ? 483 HOH B O   1 
HETATM 4494 O O   . HOH I 4 .   ? -2.736  34.089  -6.947  1.00 30.77 ? 484 HOH B O   1 
HETATM 4495 O O   . HOH I 4 .   ? -11.199 15.594  17.029  1.00 20.17 ? 485 HOH B O   1 
HETATM 4496 O O   . HOH I 4 .   ? -8.734  13.308  -12.108 1.00 9.78  ? 486 HOH B O   1 
HETATM 4497 O O   . HOH I 4 .   ? 2.649   17.259  -27.063 1.00 31.53 ? 487 HOH B O   1 
HETATM 4498 O O   . HOH I 4 .   ? 11.098  16.496  -5.880  1.00 21.46 ? 488 HOH B O   1 
HETATM 4499 O O   . HOH I 4 .   ? 1.511   30.621  -4.757  1.00 19.41 ? 489 HOH B O   1 
HETATM 4500 O O   . HOH I 4 .   ? -0.773  16.512  3.076   1.00 22.26 ? 490 HOH B O   1 
HETATM 4501 O O   . HOH I 4 .   ? 2.549   24.124  -16.879 1.00 24.83 ? 491 HOH B O   1 
HETATM 4502 O O   . HOH I 4 .   ? -13.319 11.260  -14.726 1.00 11.10 ? 492 HOH B O   1 
HETATM 4503 O O   . HOH I 4 .   ? -5.257  7.716   -5.914  1.00 16.32 ? 493 HOH B O   1 
HETATM 4504 O O   . HOH I 4 .   ? -8.185  36.298  0.904   1.00 38.48 ? 494 HOH B O   1 
HETATM 4505 O O   . HOH I 4 .   ? -13.466 18.422  22.377  1.00 16.12 ? 495 HOH B O   1 
HETATM 4506 O O   . HOH I 4 .   ? -25.735 19.628  -19.981 1.00 14.23 ? 496 HOH B O   1 
HETATM 4507 O O   . HOH I 4 .   ? -10.616 10.919  10.584  1.00 21.75 ? 497 HOH B O   1 
HETATM 4508 O O   A HOH I 4 .   ? -4.271  29.973  -6.990  0.76 17.39 ? 498 HOH B O   1 
HETATM 4509 O O   . HOH I 4 .   ? -18.191 6.700   11.291  1.00 18.01 ? 499 HOH B O   1 
HETATM 4510 O O   . HOH I 4 .   ? -12.123 6.608   -11.938 1.00 9.88  ? 500 HOH B O   1 
HETATM 4511 O O   . HOH I 4 .   ? -35.905 15.324  -3.864  1.00 20.73 ? 501 HOH B O   1 
HETATM 4512 O O   . HOH I 4 .   ? -29.346 29.872  0.740   1.00 11.05 ? 502 HOH B O   1 
HETATM 4513 O O   . HOH I 4 .   ? -16.882 37.771  -3.006  1.00 22.67 ? 503 HOH B O   1 
HETATM 4514 O O   . HOH I 4 .   ? -13.743 23.332  15.542  1.00 14.13 ? 504 HOH B O   1 
HETATM 4515 O O   . HOH I 4 .   ? -8.959  26.532  13.310  1.00 25.13 ? 505 HOH B O   1 
HETATM 4516 O O   . HOH I 4 .   ? -18.040 20.522  -26.821 1.00 23.18 ? 506 HOH B O   1 
HETATM 4517 O O   . HOH I 4 .   ? -11.935 19.835  -31.212 1.00 15.81 ? 507 HOH B O   1 
HETATM 4518 O O   . HOH I 4 .   ? -14.956 20.135  -29.942 1.00 16.00 ? 508 HOH B O   1 
HETATM 4519 O O   . HOH I 4 .   ? -16.476 33.200  8.386   1.00 16.69 ? 509 HOH B O   1 
HETATM 4520 O O   . HOH I 4 .   ? -31.716 16.047  0.539   1.00 15.89 ? 510 HOH B O   1 
HETATM 4521 O O   . HOH I 4 .   ? -33.407 1.977   -1.285  1.00 17.35 ? 511 HOH B O   1 
HETATM 4522 O O   . HOH I 4 .   ? -12.967 13.000  -3.835  1.00 13.78 ? 512 HOH B O   1 
HETATM 4523 O O   . HOH I 4 .   ? -16.444 12.178  -6.832  1.00 14.61 ? 513 HOH B O   1 
HETATM 4524 O O   . HOH I 4 .   ? -22.227 28.194  -17.385 1.00 13.80 ? 514 HOH B O   1 
HETATM 4525 O O   . HOH I 4 .   ? -28.238 4.760   -7.483  1.00 28.07 ? 515 HOH B O   1 
HETATM 4526 O O   . HOH I 4 .   ? 5.387   34.592  -22.767 1.00 24.35 ? 516 HOH B O   1 
HETATM 4527 O O   . HOH I 4 .   ? -37.102 11.005  13.220  1.00 42.69 ? 517 HOH B O   1 
HETATM 4528 O O   . HOH I 4 .   ? -27.473 34.782  -15.855 1.00 19.08 ? 518 HOH B O   1 
HETATM 4529 O O   . HOH I 4 .   ? -13.005 37.396  -5.454  1.00 25.62 ? 519 HOH B O   1 
HETATM 4530 O O   . HOH I 4 .   ? -11.660 26.912  -36.488 1.00 30.50 ? 520 HOH B O   1 
HETATM 4531 O O   . HOH I 4 .   ? -28.585 34.950  -9.786  1.00 19.99 ? 521 HOH B O   1 
HETATM 4532 O O   . HOH I 4 .   ? -21.039 10.568  17.981  1.00 29.45 ? 522 HOH B O   1 
HETATM 4533 O O   . HOH I 4 .   ? -4.618  16.036  -24.976 1.00 15.26 ? 523 HOH B O   1 
HETATM 4534 O O   . HOH I 4 .   ? -8.666  8.240   -7.017  1.00 13.69 ? 524 HOH B O   1 
HETATM 4535 O O   . HOH I 4 .   ? -19.335 27.814  9.014   1.00 20.32 ? 525 HOH B O   1 
HETATM 4536 O O   . HOH I 4 .   ? -21.886 -3.070  -2.048  1.00 18.87 ? 526 HOH B O   1 
HETATM 4537 O O   . HOH I 4 .   ? -26.221 38.546  -11.287 1.00 22.01 ? 527 HOH B O   1 
HETATM 4538 O O   . HOH I 4 .   ? -17.109 12.364  -13.664 1.00 25.24 ? 528 HOH B O   1 
HETATM 4539 O O   . HOH I 4 .   ? -19.997 6.031   3.153   1.00 14.47 ? 529 HOH B O   1 
HETATM 4540 O O   . HOH I 4 .   ? -8.101  27.352  9.525   1.00 15.98 ? 530 HOH B O   1 
HETATM 4541 O O   . HOH I 4 .   ? -27.936 -1.460  2.143   1.00 31.87 ? 531 HOH B O   1 
HETATM 4542 O O   . HOH I 4 .   ? -28.223 29.055  -24.067 1.00 24.44 ? 532 HOH B O   1 
HETATM 4543 O O   A HOH I 4 .   ? -30.854 21.392  -13.671 0.47 15.39 ? 533 HOH B O   1 
HETATM 4544 O O   B HOH I 4 .   ? -29.460 21.187  -11.702 0.53 16.06 ? 533 HOH B O   1 
HETATM 4545 O O   . HOH I 4 .   ? -14.955 13.632  14.838  1.00 16.85 ? 534 HOH B O   1 
HETATM 4546 O O   . HOH I 4 .   ? -15.839 15.688  7.110   1.00 16.56 ? 535 HOH B O   1 
HETATM 4547 O O   . HOH I 4 .   ? -33.150 26.434  -5.669  1.00 11.44 ? 536 HOH B O   1 
HETATM 4548 O O   . HOH I 4 .   ? -30.612 13.170  11.914  1.00 20.93 ? 537 HOH B O   1 
HETATM 4549 O O   . HOH I 4 .   ? -26.906 16.591  -22.072 1.00 29.25 ? 538 HOH B O   1 
HETATM 4550 O O   . HOH I 4 .   ? -0.765  26.672  5.340   1.00 27.92 ? 539 HOH B O   1 
HETATM 4551 O O   . HOH I 4 .   ? 11.464  26.054  -10.121 1.00 18.16 ? 540 HOH B O   1 
HETATM 4552 O O   . HOH I 4 .   ? -35.417 14.423  6.552   1.00 34.03 ? 541 HOH B O   1 
HETATM 4553 O O   . HOH I 4 .   ? -10.802 8.547   -9.525  1.00 13.87 ? 542 HOH B O   1 
HETATM 4554 O O   . HOH I 4 .   ? -29.192 20.685  3.103   1.00 15.96 ? 543 HOH B O   1 
HETATM 4555 O O   . HOH I 4 .   ? -13.045 7.971   8.237   1.00 28.18 ? 544 HOH B O   1 
HETATM 4556 O O   . HOH I 4 .   ? -6.165  11.095  9.555   1.00 20.15 ? 545 HOH B O   1 
HETATM 4557 O O   . HOH I 4 .   ? -10.085 6.243   0.692   1.00 20.59 ? 546 HOH B O   1 
HETATM 4558 O O   . HOH I 4 .   ? -4.955  21.540  6.165   1.00 12.20 ? 547 HOH B O   1 
HETATM 4559 O O   . HOH I 4 .   ? -30.712 1.858   -7.268  1.00 34.45 ? 548 HOH B O   1 
HETATM 4560 O O   . HOH I 4 .   ? -30.269 30.824  -2.700  1.00 13.44 ? 549 HOH B O   1 
HETATM 4561 O O   . HOH I 4 .   ? -14.796 28.509  -27.409 1.00 23.12 ? 550 HOH B O   1 
HETATM 4562 O O   . HOH I 4 .   ? -6.805  6.779   0.030   1.00 26.46 ? 551 HOH B O   1 
HETATM 4563 O O   . HOH I 4 .   ? -6.245  9.581   6.919   1.00 21.94 ? 552 HOH B O   1 
HETATM 4564 O O   . HOH I 4 .   ? -36.732 4.971   10.384  1.00 33.73 ? 553 HOH B O   1 
HETATM 4565 O O   . HOH I 4 .   ? -25.049 5.684   11.824  1.00 20.45 ? 554 HOH B O   1 
HETATM 4566 O O   . HOH I 4 .   ? -18.470 35.441  -3.496  1.00 21.68 ? 555 HOH B O   1 
HETATM 4567 O O   . HOH I 4 .   ? -22.027 18.052  -18.401 1.00 15.68 ? 556 HOH B O   1 
HETATM 4568 O O   . HOH I 4 .   ? -17.516 25.227  -14.649 1.00 19.13 ? 557 HOH B O   1 
HETATM 4569 O O   . HOH I 4 .   ? -8.639  30.888  -1.750  1.00 20.74 ? 558 HOH B O   1 
HETATM 4570 O O   . HOH I 4 .   ? -20.925 32.609  -15.657 1.00 19.50 ? 559 HOH B O   1 
HETATM 4571 O O   . HOH I 4 .   ? -29.402 23.065  9.357   1.00 28.15 ? 560 HOH B O   1 
HETATM 4572 O O   . HOH I 4 .   ? 2.566   22.544  -22.757 1.00 16.51 ? 561 HOH B O   1 
HETATM 4573 O O   . HOH I 4 .   ? -14.005 7.321   5.916   1.00 19.78 ? 562 HOH B O   1 
HETATM 4574 O O   . HOH I 4 .   ? -6.323  34.052  -19.064 1.00 18.80 ? 563 HOH B O   1 
HETATM 4575 O O   . HOH I 4 .   ? -13.709 3.939   -0.925  1.00 21.77 ? 564 HOH B O   1 
HETATM 4576 O O   . HOH I 4 .   ? -19.136 2.853   6.051   1.00 23.57 ? 565 HOH B O   1 
HETATM 4577 O O   . HOH I 4 .   ? -27.537 29.943  2.856   1.00 12.05 ? 566 HOH B O   1 
HETATM 4578 O O   . HOH I 4 .   ? 8.031   24.770  -20.394 1.00 36.24 ? 567 HOH B O   1 
HETATM 4579 O O   . HOH I 4 .   ? -6.092  23.145  13.758  1.00 25.17 ? 568 HOH B O   1 
HETATM 4580 O O   . HOH I 4 .   ? -2.966  29.496  -9.430  1.00 16.45 ? 569 HOH B O   1 
HETATM 4581 O O   . HOH I 4 .   ? -5.970  24.458  11.261  1.00 18.40 ? 570 HOH B O   1 
HETATM 4582 O O   . HOH I 4 .   ? -7.125  32.332  -0.540  1.00 30.90 ? 571 HOH B O   1 
HETATM 4583 O O   . HOH I 4 .   ? -16.902 35.520  -14.772 1.00 19.17 ? 572 HOH B O   1 
HETATM 4584 O O   . HOH I 4 .   ? -3.595  8.292   -8.628  1.00 17.11 ? 573 HOH B O   1 
HETATM 4585 O O   B HOH I 4 .   ? 4.564   31.619  -27.127 0.91 32.24 ? 574 HOH B O   1 
HETATM 4586 O O   . HOH I 4 .   ? 2.227   34.406  -18.502 1.00 26.63 ? 575 HOH B O   1 
HETATM 4587 O O   . HOH I 4 .   ? -6.431  18.361  15.117  1.00 28.57 ? 576 HOH B O   1 
HETATM 4588 O O   . HOH I 4 .   ? -34.058 5.190   -4.487  1.00 28.74 ? 577 HOH B O   1 
HETATM 4589 O O   . HOH I 4 .   ? -3.398  11.035  4.088   1.00 20.42 ? 578 HOH B O   1 
HETATM 4590 O O   . HOH I 4 .   ? -21.026 33.751  -12.765 1.00 15.37 ? 579 HOH B O   1 
HETATM 4591 O O   . HOH I 4 .   ? -26.985 16.659  8.818   1.00 16.45 ? 580 HOH B O   1 
HETATM 4592 O O   . HOH I 4 .   ? -39.553 11.093  4.011   1.00 26.29 ? 581 HOH B O   1 
HETATM 4593 O O   . HOH I 4 .   ? -27.757 33.875  -3.876  1.00 13.51 ? 582 HOH B O   1 
HETATM 4594 O O   . HOH I 4 .   ? -7.823  14.306  -24.044 1.00 17.87 ? 583 HOH B O   1 
HETATM 4595 O O   . HOH I 4 .   ? 12.130  17.019  -10.371 1.00 21.76 ? 584 HOH B O   1 
HETATM 4596 O O   . HOH I 4 .   ? -32.658 29.634  -11.733 1.00 17.03 ? 585 HOH B O   1 
HETATM 4597 O O   . HOH I 4 .   ? -2.652  22.716  11.200  1.00 24.97 ? 586 HOH B O   1 
HETATM 4598 O O   . HOH I 4 .   ? -2.671  9.512   1.936   1.00 23.86 ? 587 HOH B O   1 
HETATM 4599 O O   . HOH I 4 .   ? -19.431 28.519  -22.795 1.00 15.18 ? 588 HOH B O   1 
HETATM 4600 O O   . HOH I 4 .   ? -7.723  29.849  1.024   1.00 19.28 ? 589 HOH B O   1 
HETATM 4601 O O   . HOH I 4 .   ? -7.741  33.552  -24.890 1.00 25.00 ? 590 HOH B O   1 
HETATM 4602 O O   . HOH I 4 .   ? -32.570 27.455  -8.157  1.00 12.95 ? 591 HOH B O   1 
HETATM 4603 O O   . HOH I 4 .   ? 10.198  19.577  -6.370  1.00 18.18 ? 592 HOH B O   1 
HETATM 4604 O O   . HOH I 4 .   ? -5.928  34.316  -15.923 1.00 18.03 ? 593 HOH B O   1 
HETATM 4605 O O   . HOH I 4 .   ? -20.764 30.478  -18.428 1.00 20.03 ? 594 HOH B O   1 
HETATM 4606 O O   . HOH I 4 .   ? -22.072 4.506   4.289   1.00 16.79 ? 595 HOH B O   1 
HETATM 4607 O O   . HOH I 4 .   ? -2.157  9.622   -13.768 1.00 27.63 ? 596 HOH B O   1 
HETATM 4608 O O   . HOH I 4 .   ? -8.405  16.336  16.313  1.00 23.82 ? 597 HOH B O   1 
HETATM 4609 O O   . HOH I 4 .   ? -31.576 25.334  -2.018  1.00 16.33 ? 598 HOH B O   1 
HETATM 4610 O O   . HOH I 4 .   ? -23.460 34.664  -1.783  1.00 12.20 ? 599 HOH B O   1 
HETATM 4611 O O   . HOH I 4 .   ? -8.875  10.124  -10.271 1.00 22.93 ? 600 HOH B O   1 
HETATM 4612 O O   . HOH I 4 .   ? -16.540 24.785  10.216  1.00 19.08 ? 601 HOH B O   1 
HETATM 4613 O O   . HOH I 4 .   ? -16.992 13.281  -20.850 1.00 19.63 ? 602 HOH B O   1 
HETATM 4614 O O   . HOH I 4 .   ? -27.177 36.815  -13.513 1.00 18.20 ? 603 HOH B O   1 
HETATM 4615 O O   . HOH I 4 .   ? -2.475  19.868  13.897  1.00 24.88 ? 604 HOH B O   1 
HETATM 4616 O O   . HOH I 4 .   ? 3.592   21.217  -0.719  1.00 25.98 ? 605 HOH B O   1 
HETATM 4617 O O   . HOH I 4 .   ? -29.736 26.581  -23.998 1.00 27.19 ? 606 HOH B O   1 
HETATM 4618 O O   . HOH I 4 .   ? -29.355 2.432   9.135   1.00 28.68 ? 607 HOH B O   1 
HETATM 4619 O O   . HOH I 4 .   ? -28.296 18.545  -11.937 1.00 23.29 ? 608 HOH B O   1 
HETATM 4620 O O   . HOH I 4 .   ? -15.540 37.482  -9.007  1.00 32.11 ? 609 HOH B O   1 
HETATM 4621 O O   . HOH I 4 .   ? -9.688  20.840  20.247  1.00 20.73 ? 610 HOH B O   1 
HETATM 4622 O O   . HOH I 4 .   ? -10.741 6.997   5.572   1.00 21.52 ? 611 HOH B O   1 
HETATM 4623 O O   . HOH I 4 .   ? -3.642  27.771  10.548  1.00 31.60 ? 612 HOH B O   1 
HETATM 4624 O O   . HOH I 4 .   ? -28.114 -2.899  -0.410  1.00 28.18 ? 613 HOH B O   1 
HETATM 4625 O O   . HOH I 4 .   ? -11.515 29.464  -36.904 1.00 25.85 ? 614 HOH B O   1 
HETATM 4626 O O   . HOH I 4 .   ? -0.430  32.688  -15.372 1.00 18.71 ? 615 HOH B O   1 
HETATM 4627 O O   . HOH I 4 .   ? -9.311  35.843  -15.728 1.00 16.84 ? 616 HOH B O   1 
HETATM 4628 O O   . HOH I 4 .   ? 10.970  23.417  -2.711  1.00 31.19 ? 617 HOH B O   1 
HETATM 4629 O O   . HOH I 4 .   ? -3.877  32.736  -23.771 1.00 26.08 ? 618 HOH B O   1 
HETATM 4630 O O   . HOH I 4 .   ? -9.845  25.419  -33.649 1.00 23.40 ? 619 HOH B O   1 
HETATM 4631 O O   . HOH I 4 .   ? -18.176 21.329  -29.173 1.00 26.29 ? 620 HOH B O   1 
HETATM 4632 O O   . HOH I 4 .   ? -21.630 29.333  -21.116 1.00 24.56 ? 621 HOH B O   1 
HETATM 4633 O O   . HOH I 4 .   ? 6.434   30.632  -22.222 1.00 20.84 ? 622 HOH B O   1 
HETATM 4634 O O   . HOH I 4 .   ? -7.034  36.749  -14.950 1.00 30.97 ? 623 HOH B O   1 
HETATM 4635 O O   . HOH I 4 .   ? -0.057  12.219  1.383   1.00 26.67 ? 624 HOH B O   1 
HETATM 4636 O O   . HOH I 4 .   ? -21.842 1.602   0.496   1.00 21.02 ? 625 HOH B O   1 
HETATM 4637 O O   . HOH I 4 .   ? -23.020 4.446   -8.435  1.00 28.29 ? 626 HOH B O   1 
HETATM 4638 O O   A HOH I 4 .   ? -29.836 23.242  -25.093 0.99 21.61 ? 627 HOH B O   1 
HETATM 4639 O O   . HOH I 4 .   ? 4.529   7.175   -16.014 1.00 27.56 ? 628 HOH B O   1 
HETATM 4640 O O   . HOH I 4 .   ? -15.727 30.877  -24.409 1.00 30.30 ? 629 HOH B O   1 
HETATM 4641 O O   . HOH I 4 .   ? -22.104 12.513  -18.707 1.00 36.12 ? 630 HOH B O   1 
HETATM 4642 O O   . HOH I 4 .   ? 4.773   28.411  -20.611 1.00 25.67 ? 631 HOH B O   1 
HETATM 4643 O O   . HOH I 4 .   ? -5.200  31.262  1.529   1.00 25.01 ? 632 HOH B O   1 
HETATM 4644 O O   . HOH I 4 .   ? 4.779   26.002  -16.482 1.00 30.70 ? 633 HOH B O   1 
HETATM 4645 O O   . HOH I 4 .   ? 3.537   29.750  -0.919  1.00 25.72 ? 634 HOH B O   1 
HETATM 4646 O O   . HOH I 4 .   ? -23.489 6.017   14.697  1.00 31.15 ? 635 HOH B O   1 
HETATM 4647 O O   . HOH I 4 .   ? -12.457 38.937  -13.710 1.00 31.92 ? 636 HOH B O   1 
HETATM 4648 O O   . HOH I 4 .   ? 5.906   30.212  0.641   1.00 25.80 ? 637 HOH B O   1 
HETATM 4649 O O   . HOH I 4 .   ? 2.700   16.151  0.358   1.00 29.12 ? 638 HOH B O   1 
HETATM 4650 O O   . HOH I 4 .   ? -24.033 29.010  9.215   1.00 33.29 ? 639 HOH B O   1 
HETATM 4651 O O   . HOH I 4 .   ? -15.332 13.152  -22.754 1.00 31.42 ? 640 HOH B O   1 
HETATM 4652 O O   . HOH I 4 .   ? -37.860 7.740   -1.515  1.00 24.68 ? 641 HOH B O   1 
HETATM 4653 O O   . HOH I 4 .   ? -17.528 14.985  -14.562 1.00 22.79 ? 642 HOH B O   1 
HETATM 4654 O O   . HOH I 4 .   ? -14.591 9.381   -21.065 1.00 24.93 ? 643 HOH B O   1 
HETATM 4655 O O   . HOH I 4 .   ? -8.655  21.825  18.118  1.00 24.66 ? 644 HOH B O   1 
HETATM 4656 O O   . HOH I 4 .   ? -20.727 35.569  -1.714  1.00 18.27 ? 645 HOH B O   1 
HETATM 4657 O O   . HOH I 4 .   ? -1.738  29.269  -30.817 1.00 33.01 ? 646 HOH B O   1 
HETATM 4658 O O   . HOH I 4 .   ? -20.105 1.480   -2.607  1.00 26.15 ? 647 HOH B O   1 
HETATM 4659 O O   . HOH I 4 .   ? -16.833 28.891  9.501   1.00 24.53 ? 648 HOH B O   1 
HETATM 4660 O O   . HOH I 4 .   ? -20.989 30.101  -15.417 1.00 20.52 ? 649 HOH B O   1 
HETATM 4661 O O   . HOH I 4 .   ? -19.559 13.362  -16.710 1.00 34.23 ? 650 HOH B O   1 
HETATM 4662 O O   . HOH I 4 .   ? -0.921  26.743  -29.084 1.00 24.65 ? 651 HOH B O   1 
HETATM 4663 O O   . HOH I 4 .   ? -28.658 18.531  -19.686 1.00 33.64 ? 652 HOH B O   1 
HETATM 4664 O O   . HOH I 4 .   ? -1.637  15.075  5.003   1.00 26.53 ? 653 HOH B O   1 
HETATM 4665 O O   . HOH I 4 .   ? -31.383 16.315  3.244   1.00 23.54 ? 654 HOH B O   1 
HETATM 4666 O O   . HOH I 4 .   ? -34.235 17.079  0.285   1.00 28.74 ? 655 HOH B O   1 
HETATM 4667 O O   . HOH I 4 .   ? -10.169 28.700  10.402  1.00 26.93 ? 656 HOH B O   1 
HETATM 4668 O O   . HOH I 4 .   ? -0.977  18.417  -25.643 1.00 19.23 ? 657 HOH B O   1 
HETATM 4669 O O   . HOH I 4 .   ? -33.419 5.671   11.952  1.00 30.73 ? 658 HOH B O   1 
HETATM 4670 O O   . HOH I 4 .   ? -9.796  13.423  11.075  1.00 23.56 ? 659 HOH B O   1 
HETATM 4671 O O   . HOH I 4 .   ? -16.634 6.433   6.499   1.00 19.38 ? 660 HOH B O   1 
HETATM 4672 O O   . HOH I 4 .   ? -31.677 17.790  6.915   1.00 39.14 ? 661 HOH B O   1 
HETATM 4673 O O   . HOH I 4 .   ? 1.454   11.309  -20.103 1.00 31.46 ? 662 HOH B O   1 
HETATM 4674 O O   . HOH I 4 .   ? 9.133   29.922  -0.068  1.00 23.78 ? 663 HOH B O   1 
HETATM 4675 O O   . HOH I 4 .   ? -15.751 24.627  13.581  1.00 21.13 ? 664 HOH B O   1 
HETATM 4676 O O   . HOH I 4 .   ? -4.380  7.145   1.648   1.00 24.48 ? 665 HOH B O   1 
HETATM 4677 O O   A HOH I 4 .   ? -12.762 12.535  14.259  0.44 21.16 ? 666 HOH B O   1 
HETATM 4678 O O   B HOH I 4 .   ? -11.373 13.071  15.636  0.56 25.14 ? 666 HOH B O   1 
HETATM 4679 O O   . HOH I 4 .   ? -13.465 11.388  -22.415 1.00 24.42 ? 667 HOH B O   1 
HETATM 4680 O O   A HOH I 4 .   ? -17.479 8.467   -12.885 0.94 25.98 ? 668 HOH B O   1 
HETATM 4681 O O   . HOH I 4 .   ? 10.878  19.531  -9.799  1.00 25.00 ? 669 HOH B O   1 
HETATM 4682 O O   . HOH I 4 .   ? -19.359 5.727   0.539   1.00 13.19 ? 670 HOH B O   1 
HETATM 4683 O O   . HOH I 4 .   ? -18.988 25.713  10.795  1.00 21.83 ? 671 HOH B O   1 
HETATM 4684 O O   . HOH I 4 .   ? -10.800 15.958  19.880  1.00 28.51 ? 672 HOH B O   1 
HETATM 4685 O O   . HOH I 4 .   ? 1.530   26.660  -29.289 1.00 32.99 ? 673 HOH B O   1 
HETATM 4686 O O   . HOH I 4 .   ? -7.459  34.206  6.424   1.00 33.83 ? 674 HOH B O   1 
HETATM 4687 O O   . HOH I 4 .   ? -32.011 25.839  -14.889 1.00 19.70 ? 675 HOH B O   1 
HETATM 4688 O O   . HOH I 4 .   ? -25.704 30.722  7.321   1.00 24.88 ? 676 HOH B O   1 
HETATM 4689 O O   . HOH I 4 .   ? -2.807  9.302   6.100   1.00 35.32 ? 677 HOH B O   1 
HETATM 4690 O O   . HOH I 4 .   ? -20.506 37.808  -9.789  1.00 27.85 ? 678 HOH B O   1 
HETATM 4691 O O   . HOH I 4 .   ? -6.408  27.336  11.781  1.00 21.90 ? 679 HOH B O   1 
HETATM 4692 O O   . HOH I 4 .   ? 4.926   34.496  -19.993 1.00 29.15 ? 680 HOH B O   1 
HETATM 4693 O O   . HOH I 4 .   ? -31.495 20.077  1.970   1.00 23.49 ? 681 HOH B O   1 
HETATM 4694 O O   . HOH I 4 .   ? 10.962  21.242  -4.348  1.00 17.40 ? 682 HOH B O   1 
HETATM 4695 O O   . HOH I 4 .   ? 1.905   32.252  -16.890 1.00 27.38 ? 683 HOH B O   1 
HETATM 4696 O O   . HOH I 4 .   ? -14.288 34.846  8.709   1.00 25.62 ? 684 HOH B O   1 
HETATM 4697 O O   . HOH I 4 .   ? -27.560 17.959  15.054  1.00 35.37 ? 685 HOH B O   1 
HETATM 4698 O O   . HOH I 4 .   ? -32.343 21.317  -10.329 1.00 23.59 ? 686 HOH B O   1 
HETATM 4699 O O   . HOH I 4 .   ? -26.806 -0.985  6.266   1.00 24.78 ? 687 HOH B O   1 
HETATM 4700 O O   . HOH I 4 .   ? -29.592 0.073   -3.864  1.00 23.33 ? 688 HOH B O   1 
HETATM 4701 O O   . HOH I 4 .   ? 4.273   28.812  -17.926 1.00 33.71 ? 689 HOH B O   1 
HETATM 4702 O O   . HOH I 4 .   ? 11.795  23.406  -13.562 1.00 27.86 ? 690 HOH B O   1 
HETATM 4703 O O   . HOH I 4 .   ? -29.402 23.117  4.339   1.00 15.10 ? 691 HOH B O   1 
HETATM 4704 O O   . HOH I 4 .   ? -20.014 -0.921  -1.722  1.00 22.36 ? 692 HOH B O   1 
HETATM 4705 O O   . HOH I 4 .   ? 12.103  27.255  -2.925  1.00 15.15 ? 693 HOH B O   1 
HETATM 4706 O O   . HOH I 4 .   ? -30.950 37.835  -11.938 1.00 26.74 ? 694 HOH B O   1 
HETATM 4707 O O   . HOH I 4 .   ? -4.356  33.944  -21.178 1.00 25.39 ? 695 HOH B O   1 
HETATM 4708 O O   . HOH I 4 .   ? -20.804 36.537  -12.247 1.00 21.63 ? 696 HOH B O   1 
HETATM 4709 O O   . HOH I 4 .   ? -19.702 3.008   -0.095  1.00 18.32 ? 697 HOH B O   1 
HETATM 4710 O O   . HOH I 4 .   ? 6.370   25.964  -21.612 1.00 32.41 ? 698 HOH B O   1 
HETATM 4711 O O   . HOH I 4 .   ? -11.847 37.360  -7.789  1.00 27.15 ? 699 HOH B O   1 
HETATM 4712 O O   . HOH I 4 .   ? 9.830   26.945  -1.221  1.00 30.67 ? 700 HOH B O   1 
HETATM 4713 O O   . HOH I 4 .   ? -8.863  36.811  3.969   1.00 36.04 ? 701 HOH B O   1 
HETATM 4714 O O   A HOH I 4 .   ? -6.814  28.949  7.625   0.67 19.33 ? 702 HOH B O   1 
HETATM 4715 O O   B HOH I 4 .   ? -5.957  28.630  5.422   0.33 14.33 ? 702 HOH B O   1 
HETATM 4716 O O   . HOH I 4 .   ? -2.753  6.519   -5.084  1.00 24.18 ? 703 HOH B O   1 
HETATM 4717 O O   . HOH I 4 .   ? -32.910 27.839  -16.551 1.00 27.17 ? 704 HOH B O   1 
HETATM 4718 O O   . HOH I 4 .   ? -29.539 19.054  10.663  1.00 32.84 ? 705 HOH B O   1 
HETATM 4719 O O   . HOH I 4 .   ? -30.428 23.379  6.800   1.00 17.95 ? 706 HOH B O   1 
HETATM 4720 O O   . HOH I 4 .   ? -17.130 31.709  10.710  1.00 29.29 ? 707 HOH B O   1 
HETATM 4721 O O   . HOH I 4 .   ? -8.144  35.715  -20.164 1.00 25.30 ? 708 HOH B O   1 
HETATM 4722 O O   . HOH I 4 .   ? 11.306  23.612  -11.068 1.00 20.81 ? 709 HOH B O   1 
HETATM 4723 O O   . HOH I 4 .   ? -16.756 5.629   9.119   1.00 18.51 ? 710 HOH B O   1 
HETATM 4724 O O   . HOH I 4 .   ? -35.082 4.031   -2.014  1.00 20.89 ? 711 HOH B O   1 
HETATM 4725 O O   . HOH I 4 .   ? -16.086 4.259   2.722   1.00 23.38 ? 712 HOH B O   1 
HETATM 4726 O O   . HOH I 4 .   ? -17.383 2.260   1.041   1.00 21.60 ? 713 HOH B O   1 
HETATM 4727 O O   . HOH I 4 .   ? -32.023 26.007  0.554   1.00 26.15 ? 714 HOH B O   1 
HETATM 4728 O O   . HOH I 4 .   ? -11.661 25.060  15.611  1.00 28.08 ? 715 HOH B O   1 
HETATM 4729 O O   . HOH I 4 .   ? -31.935 28.756  0.667   1.00 15.13 ? 716 HOH B O   1 
HETATM 4730 O O   . HOH I 4 .   ? -32.605 29.634  -1.764  1.00 13.47 ? 717 HOH B O   1 
HETATM 4731 O O   A HOH I 4 .   ? 9.655   27.756  -14.107 0.59 22.69 ? 718 HOH B O   1 
HETATM 4732 O O   B HOH I 4 .   ? 8.108   27.278  -12.740 0.41 21.83 ? 718 HOH B O   1 
HETATM 4733 O O   . HOH I 4 .   ? -16.814 38.596  -11.450 1.00 31.53 ? 719 HOH B O   1 
HETATM 4734 O O   . HOH I 4 .   ? -18.346 30.673  -24.088 1.00 21.93 ? 720 HOH B O   1 
HETATM 4735 O O   . HOH I 4 .   ? -29.468 17.090  8.942   1.00 21.83 ? 721 HOH B O   1 
HETATM 4736 O O   . HOH I 4 .   ? 12.235  27.321  -12.739 1.00 21.93 ? 722 HOH B O   1 
HETATM 4737 O O   . HOH I 4 .   ? -21.381 1.836   -5.179  1.00 22.51 ? 723 HOH B O   1 
HETATM 4738 O O   . HOH I 4 .   ? -9.133  11.955  -23.054 1.00 16.40 ? 724 HOH B O   1 
HETATM 4739 O O   . HOH I 4 .   ? -10.550 5.761   3.200   1.00 32.24 ? 725 HOH B O   1 
HETATM 4740 O O   . HOH I 4 .   ? -33.230 31.111  -13.703 1.00 32.13 ? 726 HOH B O   1 
HETATM 4741 O O   . HOH I 4 .   ? -17.922 4.801   4.638   1.00 16.54 ? 727 HOH B O   1 
HETATM 4742 O O   . HOH I 4 .   ? -3.769  10.450  10.413  1.00 23.42 ? 728 HOH B O   1 
HETATM 4743 O O   . HOH I 4 .   ? -1.457  12.662  3.875   1.00 24.92 ? 729 HOH B O   1 
HETATM 4744 O O   . HOH I 4 .   ? -9.831  8.765   -21.200 1.00 26.25 ? 730 HOH B O   1 
HETATM 4745 O O   . HOH I 4 .   ? -18.353 37.368  -13.188 1.00 22.98 ? 731 HOH B O   1 
HETATM 4746 O O   . HOH I 4 .   ? -31.065 24.958  2.912   1.00 16.71 ? 732 HOH B O   1 
HETATM 4747 O O   . HOH I 4 .   ? 3.645   18.836  0.526   1.00 28.08 ? 733 HOH B O   1 
HETATM 4748 O O   . HOH I 4 .   ? -15.256 27.245  10.478  1.00 26.95 ? 734 HOH B O   1 
HETATM 4749 O O   . HOH I 4 .   ? -13.053 26.852  13.804  1.00 37.26 ? 735 HOH B O   1 
HETATM 4750 O O   . HOH I 4 .   ? -29.247 15.935  12.113  1.00 42.07 ? 736 HOH B O   1 
HETATM 4751 O O   . HOH I 4 .   ? -12.830 27.908  11.351  1.00 27.62 ? 737 HOH B O   1 
HETATM 4752 O O   . HOH I 4 .   ? -34.911 25.949  0.867   1.00 28.69 ? 738 HOH B O   1 
# 
