data_9OQE
# 
_entry.id   9OQE 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9OQE         pdb_00009oqe 10.2210/pdb9oqe/pdb 
WWPDB D_1000296119 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-18 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9OQE 
_pdbx_database_status.recvd_initial_deposition_date   2025-05-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'MicroED structure of same protein' 
_pdbx_database_related.db_id          9ORG 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              jrodriguez@mbi.ucla.edu 
_pdbx_contact_author.name_first         Jose 
_pdbx_contact_author.name_last          Rodriguez 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0248-4964 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Vlahakis, N.W.'  1 0000-0002-5092-0265 
'Rodriguez, J.A.' 2 0000-0002-0248-4964 
'Jacobs, L.M.C.'  3 ?                   
'Chen, Y.'        4 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Vlahakis, N.W.'  1  ? 
primary 'Flowers, C.W.'   2  ? 
primary 'Liu, M.'         3  ? 
primary 'Agdanowski, M.'  4  ? 
primary 'Johnson, S.'     5  ? 
primary 'Summers, J.A.'   6  ? 
primary 'Jacobs, L.M.C.'  7  ? 
primary 'Keyser, C.'      8  ? 
primary 'Russell, P.'     9  ? 
primary 'Rose, S.'        10 ? 
primary 'Orlans, J.'      11 ? 
primary 'Adhami, N.'      12 ? 
primary 'Chen, Y.'        13 ? 
primary 'Sawaya, M.R.'    14 ? 
primary 'Basu, S.'        15 ? 
primary 'De Sanctis, D.'  16 ? 
primary 'Chen, Y.'        17 ? 
primary 'Wakatsuki, S.'   18 ? 
primary 'Nelson, H.M.'    19 ? 
primary 'Loo, J.A.'       20 ? 
primary 'Tang, Y.'        21 ? 
primary 'Rodriguez, J.A.' 22 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Beta-lactamase  28000.547 2   3.5.2.6 ? 'UNP residues 23-284' ? 
2 non-polymer syn 'PHOSPHATE ION' 94.971    5   ?       ? ?                     ? 
3 non-polymer syn 'POTASSIUM ION' 39.098    2   ?       ? ?                     ? 
4 water       nat water           18.015    774 ?       ? ?                     ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PHOSPHATE ION' PO4 
3 'POTASSIUM ION' K   
4 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   THR n 
1 3   SER n 
1 4   ALA n 
1 5   VAL n 
1 6   GLN n 
1 7   GLN n 
1 8   LYS n 
1 9   LEU n 
1 10  ALA n 
1 11  ALA n 
1 12  LEU n 
1 13  GLU n 
1 14  LYS n 
1 15  SER n 
1 16  SER n 
1 17  GLY n 
1 18  GLY n 
1 19  ARG n 
1 20  LEU n 
1 21  GLY n 
1 22  VAL n 
1 23  ALA n 
1 24  LEU n 
1 25  ILE n 
1 26  ASP n 
1 27  THR n 
1 28  ALA n 
1 29  ASP n 
1 30  ASN n 
1 31  THR n 
1 32  GLN n 
1 33  VAL n 
1 34  LEU n 
1 35  TYR n 
1 36  ARG n 
1 37  GLY n 
1 38  ASP n 
1 39  GLU n 
1 40  ARG n 
1 41  PHE n 
1 42  PRO n 
1 43  MET n 
1 44  CYS n 
1 45  SER n 
1 46  THR n 
1 47  SER n 
1 48  LYS n 
1 49  VAL n 
1 50  MET n 
1 51  ALA n 
1 52  ALA n 
1 53  ALA n 
1 54  ALA n 
1 55  VAL n 
1 56  LEU n 
1 57  LYS n 
1 58  GLN n 
1 59  SER n 
1 60  GLU n 
1 61  THR n 
1 62  GLN n 
1 63  LYS n 
1 64  GLN n 
1 65  LEU n 
1 66  LEU n 
1 67  ASN n 
1 68  GLN n 
1 69  PRO n 
1 70  VAL n 
1 71  GLU n 
1 72  ILE n 
1 73  LYS n 
1 74  PRO n 
1 75  ALA n 
1 76  ASP n 
1 77  LEU n 
1 78  VAL n 
1 79  ASN n 
1 80  TYR n 
1 81  ASN n 
1 82  PRO n 
1 83  ILE n 
1 84  ALA n 
1 85  GLU n 
1 86  LYS n 
1 87  HIS n 
1 88  VAL n 
1 89  ASN n 
1 90  GLY n 
1 91  THR n 
1 92  MET n 
1 93  THR n 
1 94  LEU n 
1 95  ALA n 
1 96  GLU n 
1 97  LEU n 
1 98  SER n 
1 99  ALA n 
1 100 ALA n 
1 101 ALA n 
1 102 LEU n 
1 103 GLN n 
1 104 TYR n 
1 105 SER n 
1 106 ASP n 
1 107 ASN n 
1 108 THR n 
1 109 ALA n 
1 110 MET n 
1 111 ASN n 
1 112 LYS n 
1 113 LEU n 
1 114 ILE n 
1 115 ALA n 
1 116 GLN n 
1 117 LEU n 
1 118 GLY n 
1 119 GLY n 
1 120 PRO n 
1 121 GLY n 
1 122 GLY n 
1 123 VAL n 
1 124 THR n 
1 125 ALA n 
1 126 PHE n 
1 127 ALA n 
1 128 ARG n 
1 129 ALA n 
1 130 ILE n 
1 131 GLY n 
1 132 ASP n 
1 133 GLU n 
1 134 THR n 
1 135 PHE n 
1 136 ARG n 
1 137 LEU n 
1 138 ASP n 
1 139 ARG n 
1 140 THR n 
1 141 GLU n 
1 142 PRO n 
1 143 THR n 
1 144 LEU n 
1 145 ASN n 
1 146 THR n 
1 147 ALA n 
1 148 ILE n 
1 149 PRO n 
1 150 GLY n 
1 151 ASP n 
1 152 PRO n 
1 153 ARG n 
1 154 ASP n 
1 155 THR n 
1 156 THR n 
1 157 THR n 
1 158 PRO n 
1 159 ARG n 
1 160 ALA n 
1 161 MET n 
1 162 ALA n 
1 163 GLN n 
1 164 THR n 
1 165 LEU n 
1 166 ARG n 
1 167 GLN n 
1 168 LEU n 
1 169 THR n 
1 170 LEU n 
1 171 GLY n 
1 172 HIS n 
1 173 ALA n 
1 174 LEU n 
1 175 GLY n 
1 176 GLU n 
1 177 THR n 
1 178 GLN n 
1 179 ARG n 
1 180 ALA n 
1 181 GLN n 
1 182 LEU n 
1 183 VAL n 
1 184 THR n 
1 185 TRP n 
1 186 LEU n 
1 187 LYS n 
1 188 GLY n 
1 189 ASN n 
1 190 THR n 
1 191 THR n 
1 192 GLY n 
1 193 ALA n 
1 194 ALA n 
1 195 SER n 
1 196 ILE n 
1 197 ARG n 
1 198 ALA n 
1 199 GLY n 
1 200 LEU n 
1 201 PRO n 
1 202 THR n 
1 203 SER n 
1 204 TRP n 
1 205 THR n 
1 206 VAL n 
1 207 GLY n 
1 208 ASP n 
1 209 LYS n 
1 210 THR n 
1 211 GLY n 
1 212 SER n 
1 213 GLY n 
1 214 ASP n 
1 215 TYR n 
1 216 GLY n 
1 217 THR n 
1 218 THR n 
1 219 ASN n 
1 220 ASP n 
1 221 ILE n 
1 222 ALA n 
1 223 VAL n 
1 224 ILE n 
1 225 TRP n 
1 226 PRO n 
1 227 GLN n 
1 228 GLY n 
1 229 ARG n 
1 230 ALA n 
1 231 PRO n 
1 232 LEU n 
1 233 VAL n 
1 234 LEU n 
1 235 VAL n 
1 236 THR n 
1 237 TYR n 
1 238 PHE n 
1 239 THR n 
1 240 GLN n 
1 241 PRO n 
1 242 GLN n 
1 243 GLN n 
1 244 ASN n 
1 245 ALA n 
1 246 GLU n 
1 247 SER n 
1 248 ARG n 
1 249 ARG n 
1 250 ASP n 
1 251 VAL n 
1 252 LEU n 
1 253 ALA n 
1 254 SER n 
1 255 ALA n 
1 256 ALA n 
1 257 ARG n 
1 258 ILE n 
1 259 ILE n 
1 260 ALA n 
1 261 GLU n 
1 262 GLY n 
1 263 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   263 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 
;blaCTX-M-14, beta-lactamase CTX-M-14, bla, bla CTX-M-14, bla-CTX-M-14a, blaCTX-M, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, AM340_28340, AM465_01285, AM465_06510, AM465_23360, APT94_14605, BEN53_26220, BJJ90_27545, BK334_27290, BOH76_00730, BON63_16015, BON65_15195, BON66_01305, BON69_22545, BON72_03470, BON75_10525, BON76_14325, BON83_15455, BON86_08515, BON91_02075, BON92_04750, BON94_23850, BON95_01680, BON96_03940, BON98_23175, BXT93_06855, C5N07_28500, CDL37_21060, CR538_26855, DW236_20870, E4K51_21070, EIA08_25160, EIA21_26975, ELT23_05930, ELV24_09995, ELX61_24095, EST51_15935, EST51_18575, EST51_22260, EST51_22365, ETN48_p0088, FNJ69_13810, FTV90_03295, GE096_24920, GE096_25355, GQE36_23945, HGR36_01450, HGR36_27140, HHH24_004455, HHH24_005319, HJI79_003882, HJI79_004995, HK427_004976, HK427_005087, HL152_24835, HL152_25835, HL563_21800, HL563_23665, HLT96_25270, HLT96_28700, HLU13_27785, HLY53_18605, HLY53_26190, HLZ85_26065, HMW26_20895, HMW26_29355, HNC73_28650, HNC75_27190, HNC75_29165, HNC80_26145, HNC80_27675, HNC88_26185, HNC88_27880, HND23_26750, HND23_28285, HNV91_23425, HNV91_24920, HNV94_24095, HNV94_27845, pCT_085, pHK01_011, RCS103_P0010, RCS30_P0082, RCS56_P0085, RCS60_P0031, RCS63_P0006, RCS65_P0008, RCS66_P0053, SAMEA4362930_00013, SAMEA4363083_00099, SAMEA4370290_00046, WP4S18E07_P40650, WP7S17E01_P10270, WP7S18E09_37980
;
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     562 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION' ? 'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   25  ?   ?   ?   A . n 
A 1 2   THR 2   26  ?   ?   ?   A . n 
A 1 3   SER 3   27  27  SER SER A . n 
A 1 4   ALA 4   28  28  ALA ALA A . n 
A 1 5   VAL 5   29  29  VAL VAL A . n 
A 1 6   GLN 6   30  30  GLN GLN A . n 
A 1 7   GLN 7   31  31  GLN GLN A . n 
A 1 8   LYS 8   32  32  LYS LYS A . n 
A 1 9   LEU 9   33  33  LEU LEU A . n 
A 1 10  ALA 10  34  34  ALA ALA A . n 
A 1 11  ALA 11  35  35  ALA ALA A . n 
A 1 12  LEU 12  36  36  LEU LEU A . n 
A 1 13  GLU 13  37  37  GLU GLU A . n 
A 1 14  LYS 14  38  38  LYS LYS A . n 
A 1 15  SER 15  39  39  SER SER A . n 
A 1 16  SER 16  40  40  SER SER A . n 
A 1 17  GLY 17  41  41  GLY GLY A . n 
A 1 18  GLY 18  42  42  GLY GLY A . n 
A 1 19  ARG 19  43  43  ARG ARG A . n 
A 1 20  LEU 20  44  44  LEU LEU A . n 
A 1 21  GLY 21  45  45  GLY GLY A . n 
A 1 22  VAL 22  46  46  VAL VAL A . n 
A 1 23  ALA 23  47  47  ALA ALA A . n 
A 1 24  LEU 24  48  48  LEU LEU A . n 
A 1 25  ILE 25  49  49  ILE ILE A . n 
A 1 26  ASP 26  50  50  ASP ASP A . n 
A 1 27  THR 27  51  51  THR THR A . n 
A 1 28  ALA 28  52  52  ALA ALA A . n 
A 1 29  ASP 29  53  53  ASP ASP A . n 
A 1 30  ASN 30  54  54  ASN ASN A . n 
A 1 31  THR 31  55  55  THR THR A . n 
A 1 32  GLN 32  56  56  GLN GLN A . n 
A 1 33  VAL 33  57  57  VAL VAL A . n 
A 1 34  LEU 34  59  59  LEU LEU A . n 
A 1 35  TYR 35  60  60  TYR TYR A . n 
A 1 36  ARG 36  61  61  ARG ARG A . n 
A 1 37  GLY 37  62  62  GLY GLY A . n 
A 1 38  ASP 38  63  63  ASP ASP A . n 
A 1 39  GLU 39  64  64  GLU GLU A . n 
A 1 40  ARG 40  65  65  ARG ARG A . n 
A 1 41  PHE 41  66  66  PHE PHE A . n 
A 1 42  PRO 42  67  67  PRO PRO A . n 
A 1 43  MET 43  68  68  MET MET A . n 
A 1 44  CYS 44  69  69  CYS CYS A . n 
A 1 45  SER 45  70  70  SER SER A . n 
A 1 46  THR 46  71  71  THR THR A . n 
A 1 47  SER 47  72  72  SER SER A . n 
A 1 48  LYS 48  73  73  LYS LYS A . n 
A 1 49  VAL 49  74  74  VAL VAL A . n 
A 1 50  MET 50  75  75  MET MET A . n 
A 1 51  ALA 51  76  76  ALA ALA A . n 
A 1 52  ALA 52  77  77  ALA ALA A . n 
A 1 53  ALA 53  78  78  ALA ALA A . n 
A 1 54  ALA 54  79  79  ALA ALA A . n 
A 1 55  VAL 55  80  80  VAL VAL A . n 
A 1 56  LEU 56  81  81  LEU LEU A . n 
A 1 57  LYS 57  82  82  LYS LYS A . n 
A 1 58  GLN 58  83  83  GLN GLN A . n 
A 1 59  SER 59  84  84  SER SER A . n 
A 1 60  GLU 60  85  85  GLU GLU A . n 
A 1 61  THR 61  86  86  THR THR A . n 
A 1 62  GLN 62  87  87  GLN GLN A . n 
A 1 63  LYS 63  88  88  LYS LYS A . n 
A 1 64  GLN 64  89  89  GLN GLN A . n 
A 1 65  LEU 65  90  90  LEU LEU A . n 
A 1 66  LEU 66  91  91  LEU LEU A . n 
A 1 67  ASN 67  92  92  ASN ASN A . n 
A 1 68  GLN 68  93  93  GLN GLN A . n 
A 1 69  PRO 69  94  94  PRO PRO A . n 
A 1 70  VAL 70  95  95  VAL VAL A . n 
A 1 71  GLU 71  96  96  GLU GLU A . n 
A 1 72  ILE 72  97  97  ILE ILE A . n 
A 1 73  LYS 73  98  98  LYS LYS A . n 
A 1 74  PRO 74  99  99  PRO PRO A . n 
A 1 75  ALA 75  100 100 ALA ALA A . n 
A 1 76  ASP 76  101 101 ASP ASP A . n 
A 1 77  LEU 77  102 102 LEU LEU A . n 
A 1 78  VAL 78  103 103 VAL VAL A . n 
A 1 79  ASN 79  104 104 ASN ASN A . n 
A 1 80  TYR 80  105 105 TYR TYR A . n 
A 1 81  ASN 81  106 106 ASN ASN A . n 
A 1 82  PRO 82  107 107 PRO PRO A . n 
A 1 83  ILE 83  108 108 ILE ILE A . n 
A 1 84  ALA 84  109 109 ALA ALA A . n 
A 1 85  GLU 85  110 110 GLU GLU A . n 
A 1 86  LYS 86  111 111 LYS LYS A . n 
A 1 87  HIS 87  112 112 HIS HIS A . n 
A 1 88  VAL 88  113 113 VAL VAL A . n 
A 1 89  ASN 89  114 114 ASN ASN A . n 
A 1 90  GLY 90  115 115 GLY GLY A . n 
A 1 91  THR 91  116 116 THR THR A . n 
A 1 92  MET 92  117 117 MET MET A . n 
A 1 93  THR 93  118 118 THR THR A . n 
A 1 94  LEU 94  119 119 LEU LEU A . n 
A 1 95  ALA 95  120 120 ALA ALA A . n 
A 1 96  GLU 96  121 121 GLU GLU A . n 
A 1 97  LEU 97  122 122 LEU LEU A . n 
A 1 98  SER 98  123 123 SER SER A . n 
A 1 99  ALA 99  124 124 ALA ALA A . n 
A 1 100 ALA 100 125 125 ALA ALA A . n 
A 1 101 ALA 101 126 126 ALA ALA A . n 
A 1 102 LEU 102 127 127 LEU LEU A . n 
A 1 103 GLN 103 128 128 GLN GLN A . n 
A 1 104 TYR 104 129 129 TYR TYR A . n 
A 1 105 SER 105 130 130 SER SER A . n 
A 1 106 ASP 106 131 131 ASP ASP A . n 
A 1 107 ASN 107 132 132 ASN ASN A . n 
A 1 108 THR 108 133 133 THR THR A . n 
A 1 109 ALA 109 134 134 ALA ALA A . n 
A 1 110 MET 110 135 135 MET MET A . n 
A 1 111 ASN 111 136 136 ASN ASN A . n 
A 1 112 LYS 112 137 137 LYS LYS A . n 
A 1 113 LEU 113 138 138 LEU LEU A . n 
A 1 114 ILE 114 139 139 ILE ILE A . n 
A 1 115 ALA 115 140 140 ALA ALA A . n 
A 1 116 GLN 116 141 141 GLN GLN A . n 
A 1 117 LEU 117 142 142 LEU LEU A . n 
A 1 118 GLY 118 143 143 GLY GLY A . n 
A 1 119 GLY 119 144 144 GLY GLY A . n 
A 1 120 PRO 120 145 145 PRO PRO A . n 
A 1 121 GLY 121 146 146 GLY GLY A . n 
A 1 122 GLY 122 147 147 GLY GLY A . n 
A 1 123 VAL 123 148 148 VAL VAL A . n 
A 1 124 THR 124 149 149 THR THR A . n 
A 1 125 ALA 125 150 150 ALA ALA A . n 
A 1 126 PHE 126 151 151 PHE PHE A . n 
A 1 127 ALA 127 152 152 ALA ALA A . n 
A 1 128 ARG 128 153 153 ARG ARG A . n 
A 1 129 ALA 129 154 154 ALA ALA A . n 
A 1 130 ILE 130 155 155 ILE ILE A . n 
A 1 131 GLY 131 156 156 GLY GLY A . n 
A 1 132 ASP 132 157 157 ASP ASP A . n 
A 1 133 GLU 133 158 158 GLU GLU A . n 
A 1 134 THR 134 159 159 THR THR A . n 
A 1 135 PHE 135 160 160 PHE PHE A . n 
A 1 136 ARG 136 161 161 ARG ARG A . n 
A 1 137 LEU 137 162 162 LEU LEU A . n 
A 1 138 ASP 138 163 163 ASP ASP A . n 
A 1 139 ARG 139 164 164 ARG ARG A . n 
A 1 140 THR 140 165 165 THR THR A . n 
A 1 141 GLU 141 166 166 GLU GLU A . n 
A 1 142 PRO 142 167 167 PRO PRO A . n 
A 1 143 THR 143 168 168 THR THR A . n 
A 1 144 LEU 144 169 169 LEU LEU A . n 
A 1 145 ASN 145 170 170 ASN ASN A . n 
A 1 146 THR 146 171 171 THR THR A . n 
A 1 147 ALA 147 172 172 ALA ALA A . n 
A 1 148 ILE 148 173 173 ILE ILE A . n 
A 1 149 PRO 149 174 174 PRO PRO A . n 
A 1 150 GLY 150 175 175 GLY GLY A . n 
A 1 151 ASP 151 176 176 ASP ASP A . n 
A 1 152 PRO 152 177 177 PRO PRO A . n 
A 1 153 ARG 153 178 178 ARG ARG A . n 
A 1 154 ASP 154 179 179 ASP ASP A . n 
A 1 155 THR 155 180 180 THR THR A . n 
A 1 156 THR 156 181 181 THR THR A . n 
A 1 157 THR 157 182 182 THR THR A . n 
A 1 158 PRO 158 183 183 PRO PRO A . n 
A 1 159 ARG 159 184 184 ARG ARG A . n 
A 1 160 ALA 160 185 185 ALA ALA A . n 
A 1 161 MET 161 186 186 MET MET A . n 
A 1 162 ALA 162 187 187 ALA ALA A . n 
A 1 163 GLN 163 188 188 GLN GLN A . n 
A 1 164 THR 164 189 189 THR THR A . n 
A 1 165 LEU 165 190 190 LEU LEU A . n 
A 1 166 ARG 166 191 191 ARG ARG A . n 
A 1 167 GLN 167 192 192 GLN GLN A . n 
A 1 168 LEU 168 193 193 LEU LEU A . n 
A 1 169 THR 169 194 194 THR THR A . n 
A 1 170 LEU 170 195 195 LEU LEU A . n 
A 1 171 GLY 171 196 196 GLY GLY A . n 
A 1 172 HIS 172 197 197 HIS HIS A . n 
A 1 173 ALA 173 198 198 ALA ALA A . n 
A 1 174 LEU 174 199 199 LEU LEU A . n 
A 1 175 GLY 175 200 200 GLY GLY A . n 
A 1 176 GLU 176 201 201 GLU GLU A . n 
A 1 177 THR 177 202 202 THR THR A . n 
A 1 178 GLN 178 203 203 GLN GLN A . n 
A 1 179 ARG 179 204 204 ARG ARG A . n 
A 1 180 ALA 180 205 205 ALA ALA A . n 
A 1 181 GLN 181 206 206 GLN GLN A . n 
A 1 182 LEU 182 207 207 LEU LEU A . n 
A 1 183 VAL 183 208 208 VAL VAL A . n 
A 1 184 THR 184 209 209 THR THR A . n 
A 1 185 TRP 185 210 210 TRP TRP A . n 
A 1 186 LEU 186 211 211 LEU LEU A . n 
A 1 187 LYS 187 212 212 LYS LYS A . n 
A 1 188 GLY 188 213 213 GLY GLY A . n 
A 1 189 ASN 189 214 214 ASN ASN A . n 
A 1 190 THR 190 215 215 THR THR A . n 
A 1 191 THR 191 216 216 THR THR A . n 
A 1 192 GLY 192 217 217 GLY GLY A . n 
A 1 193 ALA 193 218 218 ALA ALA A . n 
A 1 194 ALA 194 219 219 ALA ALA A . n 
A 1 195 SER 195 220 220 SER SER A . n 
A 1 196 ILE 196 221 221 ILE ILE A . n 
A 1 197 ARG 197 222 222 ARG ARG A . n 
A 1 198 ALA 198 223 223 ALA ALA A . n 
A 1 199 GLY 199 224 224 GLY GLY A . n 
A 1 200 LEU 200 225 225 LEU LEU A . n 
A 1 201 PRO 201 226 226 PRO PRO A . n 
A 1 202 THR 202 227 227 THR THR A . n 
A 1 203 SER 203 228 228 SER SER A . n 
A 1 204 TRP 204 229 229 TRP TRP A . n 
A 1 205 THR 205 230 230 THR THR A . n 
A 1 206 VAL 206 231 231 VAL VAL A . n 
A 1 207 GLY 207 232 232 GLY GLY A . n 
A 1 208 ASP 208 233 233 ASP ASP A . n 
A 1 209 LYS 209 234 234 LYS LYS A . n 
A 1 210 THR 210 235 235 THR THR A . n 
A 1 211 GLY 211 236 236 GLY GLY A . n 
A 1 212 SER 212 237 237 SER SER A . n 
A 1 213 GLY 213 238 238 GLY GLY A . n 
A 1 214 ASP 214 240 240 ASP ASP A . n 
A 1 215 TYR 215 241 241 TYR TYR A . n 
A 1 216 GLY 216 242 242 GLY GLY A . n 
A 1 217 THR 217 243 243 THR THR A . n 
A 1 218 THR 218 244 244 THR THR A . n 
A 1 219 ASN 219 245 245 ASN ASN A . n 
A 1 220 ASP 220 246 246 ASP ASP A . n 
A 1 221 ILE 221 247 247 ILE ILE A . n 
A 1 222 ALA 222 248 248 ALA ALA A . n 
A 1 223 VAL 223 249 249 VAL VAL A . n 
A 1 224 ILE 224 250 250 ILE ILE A . n 
A 1 225 TRP 225 251 251 TRP TRP A . n 
A 1 226 PRO 226 252 252 PRO PRO A . n 
A 1 227 GLN 227 254 254 GLN GLN A . n 
A 1 228 GLY 228 255 255 GLY GLY A . n 
A 1 229 ARG 229 256 256 ARG ARG A . n 
A 1 230 ALA 230 257 257 ALA ALA A . n 
A 1 231 PRO 231 258 258 PRO PRO A . n 
A 1 232 LEU 232 259 259 LEU LEU A . n 
A 1 233 VAL 233 260 260 VAL VAL A . n 
A 1 234 LEU 234 261 261 LEU LEU A . n 
A 1 235 VAL 235 262 262 VAL VAL A . n 
A 1 236 THR 236 263 263 THR THR A . n 
A 1 237 TYR 237 264 264 TYR TYR A . n 
A 1 238 PHE 238 265 265 PHE PHE A . n 
A 1 239 THR 239 266 266 THR THR A . n 
A 1 240 GLN 240 267 267 GLN GLN A . n 
A 1 241 PRO 241 268 268 PRO PRO A . n 
A 1 242 GLN 242 269 269 GLN GLN A . n 
A 1 243 GLN 243 270 270 GLN GLN A . n 
A 1 244 ASN 244 271 271 ASN ASN A . n 
A 1 245 ALA 245 272 272 ALA ALA A . n 
A 1 246 GLU 246 273 273 GLU GLU A . n 
A 1 247 SER 247 274 274 SER SER A . n 
A 1 248 ARG 248 275 275 ARG ARG A . n 
A 1 249 ARG 249 276 276 ARG ARG A . n 
A 1 250 ASP 250 277 277 ASP ASP A . n 
A 1 251 VAL 251 278 278 VAL VAL A . n 
A 1 252 LEU 252 279 279 LEU LEU A . n 
A 1 253 ALA 253 280 280 ALA ALA A . n 
A 1 254 SER 254 281 281 SER SER A . n 
A 1 255 ALA 255 282 282 ALA ALA A . n 
A 1 256 ALA 256 283 283 ALA ALA A . n 
A 1 257 ARG 257 284 284 ARG ARG A . n 
A 1 258 ILE 258 285 285 ILE ILE A . n 
A 1 259 ILE 259 286 286 ILE ILE A . n 
A 1 260 ALA 260 287 287 ALA ALA A . n 
A 1 261 GLU 261 288 288 GLU GLU A . n 
A 1 262 GLY 262 289 289 GLY GLY A . n 
A 1 263 LEU 263 290 290 LEU LEU A . n 
B 1 1   GLN 1   25  25  GLN GLN B . n 
B 1 2   THR 2   26  26  THR THR B . n 
B 1 3   SER 3   27  27  SER SER B . n 
B 1 4   ALA 4   28  28  ALA ALA B . n 
B 1 5   VAL 5   29  29  VAL VAL B . n 
B 1 6   GLN 6   30  30  GLN GLN B . n 
B 1 7   GLN 7   31  31  GLN GLN B . n 
B 1 8   LYS 8   32  32  LYS LYS B . n 
B 1 9   LEU 9   33  33  LEU LEU B . n 
B 1 10  ALA 10  34  34  ALA ALA B . n 
B 1 11  ALA 11  35  35  ALA ALA B . n 
B 1 12  LEU 12  36  36  LEU LEU B . n 
B 1 13  GLU 13  37  37  GLU GLU B . n 
B 1 14  LYS 14  38  38  LYS LYS B . n 
B 1 15  SER 15  39  39  SER SER B . n 
B 1 16  SER 16  40  40  SER SER B . n 
B 1 17  GLY 17  41  41  GLY GLY B . n 
B 1 18  GLY 18  42  42  GLY GLY B . n 
B 1 19  ARG 19  43  43  ARG ARG B . n 
B 1 20  LEU 20  44  44  LEU LEU B . n 
B 1 21  GLY 21  45  45  GLY GLY B . n 
B 1 22  VAL 22  46  46  VAL VAL B . n 
B 1 23  ALA 23  47  47  ALA ALA B . n 
B 1 24  LEU 24  48  48  LEU LEU B . n 
B 1 25  ILE 25  49  49  ILE ILE B . n 
B 1 26  ASP 26  50  50  ASP ASP B . n 
B 1 27  THR 27  51  51  THR THR B . n 
B 1 28  ALA 28  52  52  ALA ALA B . n 
B 1 29  ASP 29  53  53  ASP ASP B . n 
B 1 30  ASN 30  54  54  ASN ASN B . n 
B 1 31  THR 31  55  55  THR THR B . n 
B 1 32  GLN 32  56  56  GLN GLN B . n 
B 1 33  VAL 33  57  57  VAL VAL B . n 
B 1 34  LEU 34  59  59  LEU LEU B . n 
B 1 35  TYR 35  60  60  TYR TYR B . n 
B 1 36  ARG 36  61  61  ARG ARG B . n 
B 1 37  GLY 37  62  62  GLY GLY B . n 
B 1 38  ASP 38  63  63  ASP ASP B . n 
B 1 39  GLU 39  64  64  GLU GLU B . n 
B 1 40  ARG 40  65  65  ARG ARG B . n 
B 1 41  PHE 41  66  66  PHE PHE B . n 
B 1 42  PRO 42  67  67  PRO PRO B . n 
B 1 43  MET 43  68  68  MET MET B . n 
B 1 44  CYS 44  69  69  CYS CYS B . n 
B 1 45  SER 45  70  70  SER SER B . n 
B 1 46  THR 46  71  71  THR THR B . n 
B 1 47  SER 47  72  72  SER SER B . n 
B 1 48  LYS 48  73  73  LYS LYS B . n 
B 1 49  VAL 49  74  74  VAL VAL B . n 
B 1 50  MET 50  75  75  MET MET B . n 
B 1 51  ALA 51  76  76  ALA ALA B . n 
B 1 52  ALA 52  77  77  ALA ALA B . n 
B 1 53  ALA 53  78  78  ALA ALA B . n 
B 1 54  ALA 54  79  79  ALA ALA B . n 
B 1 55  VAL 55  80  80  VAL VAL B . n 
B 1 56  LEU 56  81  81  LEU LEU B . n 
B 1 57  LYS 57  82  82  LYS LYS B . n 
B 1 58  GLN 58  83  83  GLN GLN B . n 
B 1 59  SER 59  84  84  SER SER B . n 
B 1 60  GLU 60  85  85  GLU GLU B . n 
B 1 61  THR 61  86  86  THR THR B . n 
B 1 62  GLN 62  87  87  GLN GLN B . n 
B 1 63  LYS 63  88  88  LYS LYS B . n 
B 1 64  GLN 64  89  89  GLN GLN B . n 
B 1 65  LEU 65  90  90  LEU LEU B . n 
B 1 66  LEU 66  91  91  LEU LEU B . n 
B 1 67  ASN 67  92  92  ASN ASN B . n 
B 1 68  GLN 68  93  93  GLN GLN B . n 
B 1 69  PRO 69  94  94  PRO PRO B . n 
B 1 70  VAL 70  95  95  VAL VAL B . n 
B 1 71  GLU 71  96  96  GLU GLU B . n 
B 1 72  ILE 72  97  97  ILE ILE B . n 
B 1 73  LYS 73  98  98  LYS LYS B . n 
B 1 74  PRO 74  99  99  PRO PRO B . n 
B 1 75  ALA 75  100 100 ALA ALA B . n 
B 1 76  ASP 76  101 101 ASP ASP B . n 
B 1 77  LEU 77  102 102 LEU LEU B . n 
B 1 78  VAL 78  103 103 VAL VAL B . n 
B 1 79  ASN 79  104 104 ASN ASN B . n 
B 1 80  TYR 80  105 105 TYR TYR B . n 
B 1 81  ASN 81  106 106 ASN ASN B . n 
B 1 82  PRO 82  107 107 PRO PRO B . n 
B 1 83  ILE 83  108 108 ILE ILE B . n 
B 1 84  ALA 84  109 109 ALA ALA B . n 
B 1 85  GLU 85  110 110 GLU GLU B . n 
B 1 86  LYS 86  111 111 LYS LYS B . n 
B 1 87  HIS 87  112 112 HIS HIS B . n 
B 1 88  VAL 88  113 113 VAL VAL B . n 
B 1 89  ASN 89  114 114 ASN ASN B . n 
B 1 90  GLY 90  115 115 GLY GLY B . n 
B 1 91  THR 91  116 116 THR THR B . n 
B 1 92  MET 92  117 117 MET MET B . n 
B 1 93  THR 93  118 118 THR THR B . n 
B 1 94  LEU 94  119 119 LEU LEU B . n 
B 1 95  ALA 95  120 120 ALA ALA B . n 
B 1 96  GLU 96  121 121 GLU GLU B . n 
B 1 97  LEU 97  122 122 LEU LEU B . n 
B 1 98  SER 98  123 123 SER SER B . n 
B 1 99  ALA 99  124 124 ALA ALA B . n 
B 1 100 ALA 100 125 125 ALA ALA B . n 
B 1 101 ALA 101 126 126 ALA ALA B . n 
B 1 102 LEU 102 127 127 LEU LEU B . n 
B 1 103 GLN 103 128 128 GLN GLN B . n 
B 1 104 TYR 104 129 129 TYR TYR B . n 
B 1 105 SER 105 130 130 SER SER B . n 
B 1 106 ASP 106 131 131 ASP ASP B . n 
B 1 107 ASN 107 132 132 ASN ASN B . n 
B 1 108 THR 108 133 133 THR THR B . n 
B 1 109 ALA 109 134 134 ALA ALA B . n 
B 1 110 MET 110 135 135 MET MET B . n 
B 1 111 ASN 111 136 136 ASN ASN B . n 
B 1 112 LYS 112 137 137 LYS LYS B . n 
B 1 113 LEU 113 138 138 LEU LEU B . n 
B 1 114 ILE 114 139 139 ILE ILE B . n 
B 1 115 ALA 115 140 140 ALA ALA B . n 
B 1 116 GLN 116 141 141 GLN GLN B . n 
B 1 117 LEU 117 142 142 LEU LEU B . n 
B 1 118 GLY 118 143 143 GLY GLY B . n 
B 1 119 GLY 119 144 144 GLY GLY B . n 
B 1 120 PRO 120 145 145 PRO PRO B . n 
B 1 121 GLY 121 146 146 GLY GLY B . n 
B 1 122 GLY 122 147 147 GLY GLY B . n 
B 1 123 VAL 123 148 148 VAL VAL B . n 
B 1 124 THR 124 149 149 THR THR B . n 
B 1 125 ALA 125 150 150 ALA ALA B . n 
B 1 126 PHE 126 151 151 PHE PHE B . n 
B 1 127 ALA 127 152 152 ALA ALA B . n 
B 1 128 ARG 128 153 153 ARG ARG B . n 
B 1 129 ALA 129 154 154 ALA ALA B . n 
B 1 130 ILE 130 155 155 ILE ILE B . n 
B 1 131 GLY 131 156 156 GLY GLY B . n 
B 1 132 ASP 132 157 157 ASP ASP B . n 
B 1 133 GLU 133 158 158 GLU GLU B . n 
B 1 134 THR 134 159 159 THR THR B . n 
B 1 135 PHE 135 160 160 PHE PHE B . n 
B 1 136 ARG 136 161 161 ARG ARG B . n 
B 1 137 LEU 137 162 162 LEU LEU B . n 
B 1 138 ASP 138 163 163 ASP ASP B . n 
B 1 139 ARG 139 164 164 ARG ARG B . n 
B 1 140 THR 140 165 165 THR THR B . n 
B 1 141 GLU 141 166 166 GLU GLU B . n 
B 1 142 PRO 142 167 167 PRO PRO B . n 
B 1 143 THR 143 168 168 THR THR B . n 
B 1 144 LEU 144 169 169 LEU LEU B . n 
B 1 145 ASN 145 170 170 ASN ASN B . n 
B 1 146 THR 146 171 171 THR THR B . n 
B 1 147 ALA 147 172 172 ALA ALA B . n 
B 1 148 ILE 148 173 173 ILE ILE B . n 
B 1 149 PRO 149 174 174 PRO PRO B . n 
B 1 150 GLY 150 175 175 GLY GLY B . n 
B 1 151 ASP 151 176 176 ASP ASP B . n 
B 1 152 PRO 152 177 177 PRO PRO B . n 
B 1 153 ARG 153 178 178 ARG ARG B . n 
B 1 154 ASP 154 179 179 ASP ASP B . n 
B 1 155 THR 155 180 180 THR THR B . n 
B 1 156 THR 156 181 181 THR THR B . n 
B 1 157 THR 157 182 182 THR THR B . n 
B 1 158 PRO 158 183 183 PRO PRO B . n 
B 1 159 ARG 159 184 184 ARG ARG B . n 
B 1 160 ALA 160 185 185 ALA ALA B . n 
B 1 161 MET 161 186 186 MET MET B . n 
B 1 162 ALA 162 187 187 ALA ALA B . n 
B 1 163 GLN 163 188 188 GLN GLN B . n 
B 1 164 THR 164 189 189 THR THR B . n 
B 1 165 LEU 165 190 190 LEU LEU B . n 
B 1 166 ARG 166 191 191 ARG ARG B . n 
B 1 167 GLN 167 192 192 GLN GLN B . n 
B 1 168 LEU 168 193 193 LEU LEU B . n 
B 1 169 THR 169 194 194 THR THR B . n 
B 1 170 LEU 170 195 195 LEU LEU B . n 
B 1 171 GLY 171 196 196 GLY GLY B . n 
B 1 172 HIS 172 197 197 HIS HIS B . n 
B 1 173 ALA 173 198 198 ALA ALA B . n 
B 1 174 LEU 174 199 199 LEU LEU B . n 
B 1 175 GLY 175 200 200 GLY GLY B . n 
B 1 176 GLU 176 201 201 GLU GLU B . n 
B 1 177 THR 177 202 202 THR THR B . n 
B 1 178 GLN 178 203 203 GLN GLN B . n 
B 1 179 ARG 179 204 204 ARG ARG B . n 
B 1 180 ALA 180 205 205 ALA ALA B . n 
B 1 181 GLN 181 206 206 GLN GLN B . n 
B 1 182 LEU 182 207 207 LEU LEU B . n 
B 1 183 VAL 183 208 208 VAL VAL B . n 
B 1 184 THR 184 209 209 THR THR B . n 
B 1 185 TRP 185 210 210 TRP TRP B . n 
B 1 186 LEU 186 211 211 LEU LEU B . n 
B 1 187 LYS 187 212 212 LYS LYS B . n 
B 1 188 GLY 188 213 213 GLY GLY B . n 
B 1 189 ASN 189 214 214 ASN ASN B . n 
B 1 190 THR 190 215 215 THR THR B . n 
B 1 191 THR 191 216 216 THR THR B . n 
B 1 192 GLY 192 217 217 GLY GLY B . n 
B 1 193 ALA 193 218 218 ALA ALA B . n 
B 1 194 ALA 194 219 219 ALA ALA B . n 
B 1 195 SER 195 220 220 SER SER B . n 
B 1 196 ILE 196 221 221 ILE ILE B . n 
B 1 197 ARG 197 222 222 ARG ARG B . n 
B 1 198 ALA 198 223 223 ALA ALA B . n 
B 1 199 GLY 199 224 224 GLY GLY B . n 
B 1 200 LEU 200 225 225 LEU LEU B . n 
B 1 201 PRO 201 226 226 PRO PRO B . n 
B 1 202 THR 202 227 227 THR THR B . n 
B 1 203 SER 203 228 228 SER SER B . n 
B 1 204 TRP 204 229 229 TRP TRP B . n 
B 1 205 THR 205 230 230 THR THR B . n 
B 1 206 VAL 206 231 231 VAL VAL B . n 
B 1 207 GLY 207 232 232 GLY GLY B . n 
B 1 208 ASP 208 233 233 ASP ASP B . n 
B 1 209 LYS 209 234 234 LYS LYS B . n 
B 1 210 THR 210 235 235 THR THR B . n 
B 1 211 GLY 211 236 236 GLY GLY B . n 
B 1 212 SER 212 237 237 SER SER B . n 
B 1 213 GLY 213 238 238 GLY GLY B . n 
B 1 214 ASP 214 240 240 ASP ASP B . n 
B 1 215 TYR 215 241 241 TYR TYR B . n 
B 1 216 GLY 216 242 242 GLY GLY B . n 
B 1 217 THR 217 243 243 THR THR B . n 
B 1 218 THR 218 244 244 THR THR B . n 
B 1 219 ASN 219 245 245 ASN ASN B . n 
B 1 220 ASP 220 246 246 ASP ASP B . n 
B 1 221 ILE 221 247 247 ILE ILE B . n 
B 1 222 ALA 222 248 248 ALA ALA B . n 
B 1 223 VAL 223 249 249 VAL VAL B . n 
B 1 224 ILE 224 250 250 ILE ILE B . n 
B 1 225 TRP 225 251 251 TRP TRP B . n 
B 1 226 PRO 226 252 252 PRO PRO B . n 
B 1 227 GLN 227 254 254 GLN GLN B . n 
B 1 228 GLY 228 255 255 GLY GLY B . n 
B 1 229 ARG 229 256 256 ARG ARG B . n 
B 1 230 ALA 230 257 257 ALA ALA B . n 
B 1 231 PRO 231 258 258 PRO PRO B . n 
B 1 232 LEU 232 259 259 LEU LEU B . n 
B 1 233 VAL 233 260 260 VAL VAL B . n 
B 1 234 LEU 234 261 261 LEU LEU B . n 
B 1 235 VAL 235 262 262 VAL VAL B . n 
B 1 236 THR 236 263 263 THR THR B . n 
B 1 237 TYR 237 264 264 TYR TYR B . n 
B 1 238 PHE 238 265 265 PHE PHE B . n 
B 1 239 THR 239 266 266 THR THR B . n 
B 1 240 GLN 240 267 267 GLN GLN B . n 
B 1 241 PRO 241 268 268 PRO PRO B . n 
B 1 242 GLN 242 269 269 GLN GLN B . n 
B 1 243 GLN 243 270 270 GLN GLN B . n 
B 1 244 ASN 244 271 271 ASN ASN B . n 
B 1 245 ALA 245 272 272 ALA ALA B . n 
B 1 246 GLU 246 273 273 GLU GLU B . n 
B 1 247 SER 247 274 274 SER SER B . n 
B 1 248 ARG 248 275 275 ARG ARG B . n 
B 1 249 ARG 249 276 276 ARG ARG B . n 
B 1 250 ASP 250 277 277 ASP ASP B . n 
B 1 251 VAL 251 278 278 VAL VAL B . n 
B 1 252 LEU 252 279 279 LEU LEU B . n 
B 1 253 ALA 253 280 280 ALA ALA B . n 
B 1 254 SER 254 281 281 SER SER B . n 
B 1 255 ALA 255 282 282 ALA ALA B . n 
B 1 256 ALA 256 283 283 ALA ALA B . n 
B 1 257 ARG 257 284 284 ARG ARG B . n 
B 1 258 ILE 258 285 285 ILE ILE B . n 
B 1 259 ILE 259 286 286 ILE ILE B . n 
B 1 260 ALA 260 287 287 ALA ALA B . n 
B 1 261 GLU 261 288 288 GLU GLU B . n 
B 1 262 GLY 262 289 289 GLY GLY B . n 
B 1 263 LEU 263 290 290 LEU LEU B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 PO4 1   301 1   PO4 PO4 A . 
D 2 PO4 1   302 3   PO4 PO4 A . 
E 3 K   1   303 1   K   K   A . 
F 2 PO4 1   301 2   PO4 PO4 B . 
G 2 PO4 1   302 4   PO4 PO4 B . 
H 2 PO4 1   303 5   PO4 PO4 B . 
I 3 K   1   304 2   K   K   B . 
J 4 HOH 1   401 788 HOH HOH A . 
J 4 HOH 2   402 493 HOH HOH A . 
J 4 HOH 3   403 348 HOH HOH A . 
J 4 HOH 4   404 538 HOH HOH A . 
J 4 HOH 5   405 567 HOH HOH A . 
J 4 HOH 6   406 766 HOH HOH A . 
J 4 HOH 7   407 761 HOH HOH A . 
J 4 HOH 8   408 373 HOH HOH A . 
J 4 HOH 9   409 525 HOH HOH A . 
J 4 HOH 10  410 271 HOH HOH A . 
J 4 HOH 11  411 646 HOH HOH A . 
J 4 HOH 12  412 208 HOH HOH A . 
J 4 HOH 13  413 227 HOH HOH A . 
J 4 HOH 14  414 239 HOH HOH A . 
J 4 HOH 15  415 712 HOH HOH A . 
J 4 HOH 16  416 446 HOH HOH A . 
J 4 HOH 17  417 774 HOH HOH A . 
J 4 HOH 18  418 165 HOH HOH A . 
J 4 HOH 19  419 343 HOH HOH A . 
J 4 HOH 20  420 465 HOH HOH A . 
J 4 HOH 21  421 11  HOH HOH A . 
J 4 HOH 22  422 247 HOH HOH A . 
J 4 HOH 23  423 478 HOH HOH A . 
J 4 HOH 24  424 382 HOH HOH A . 
J 4 HOH 25  425 174 HOH HOH A . 
J 4 HOH 26  426 40  HOH HOH A . 
J 4 HOH 27  427 274 HOH HOH A . 
J 4 HOH 28  428 276 HOH HOH A . 
J 4 HOH 29  429 545 HOH HOH A . 
J 4 HOH 30  430 302 HOH HOH A . 
J 4 HOH 31  431 320 HOH HOH A . 
J 4 HOH 32  432 574 HOH HOH A . 
J 4 HOH 33  433 686 HOH HOH A . 
J 4 HOH 34  434 469 HOH HOH A . 
J 4 HOH 35  435 709 HOH HOH A . 
J 4 HOH 36  436 555 HOH HOH A . 
J 4 HOH 37  437 550 HOH HOH A . 
J 4 HOH 38  438 84  HOH HOH A . 
J 4 HOH 39  439 15  HOH HOH A . 
J 4 HOH 40  440 575 HOH HOH A . 
J 4 HOH 41  441 294 HOH HOH A . 
J 4 HOH 42  442 80  HOH HOH A . 
J 4 HOH 43  443 447 HOH HOH A . 
J 4 HOH 44  444 770 HOH HOH A . 
J 4 HOH 45  445 220 HOH HOH A . 
J 4 HOH 46  446 454 HOH HOH A . 
J 4 HOH 47  447 755 HOH HOH A . 
J 4 HOH 48  448 532 HOH HOH A . 
J 4 HOH 49  449 222 HOH HOH A . 
J 4 HOH 50  450 233 HOH HOH A . 
J 4 HOH 51  451 51  HOH HOH A . 
J 4 HOH 52  452 65  HOH HOH A . 
J 4 HOH 53  453 735 HOH HOH A . 
J 4 HOH 54  454 181 HOH HOH A . 
J 4 HOH 55  455 448 HOH HOH A . 
J 4 HOH 56  456 639 HOH HOH A . 
J 4 HOH 57  457 667 HOH HOH A . 
J 4 HOH 58  458 89  HOH HOH A . 
J 4 HOH 59  459 505 HOH HOH A . 
J 4 HOH 60  460 309 HOH HOH A . 
J 4 HOH 61  461 282 HOH HOH A . 
J 4 HOH 62  462 236 HOH HOH A . 
J 4 HOH 63  463 416 HOH HOH A . 
J 4 HOH 64  464 136 HOH HOH A . 
J 4 HOH 65  465 524 HOH HOH A . 
J 4 HOH 66  466 483 HOH HOH A . 
J 4 HOH 67  467 418 HOH HOH A . 
J 4 HOH 68  468 435 HOH HOH A . 
J 4 HOH 69  469 189 HOH HOH A . 
J 4 HOH 70  470 32  HOH HOH A . 
J 4 HOH 71  471 16  HOH HOH A . 
J 4 HOH 72  472 564 HOH HOH A . 
J 4 HOH 73  473 47  HOH HOH A . 
J 4 HOH 74  474 644 HOH HOH A . 
J 4 HOH 75  475 444 HOH HOH A . 
J 4 HOH 76  476 29  HOH HOH A . 
J 4 HOH 77  477 141 HOH HOH A . 
J 4 HOH 78  478 116 HOH HOH A . 
J 4 HOH 79  479 645 HOH HOH A . 
J 4 HOH 80  480 90  HOH HOH A . 
J 4 HOH 81  481 466 HOH HOH A . 
J 4 HOH 82  482 681 HOH HOH A . 
J 4 HOH 83  483 134 HOH HOH A . 
J 4 HOH 84  484 66  HOH HOH A . 
J 4 HOH 85  485 102 HOH HOH A . 
J 4 HOH 86  486 67  HOH HOH A . 
J 4 HOH 87  487 398 HOH HOH A . 
J 4 HOH 88  488 315 HOH HOH A . 
J 4 HOH 89  489 588 HOH HOH A . 
J 4 HOH 90  490 760 HOH HOH A . 
J 4 HOH 91  491 618 HOH HOH A . 
J 4 HOH 92  492 296 HOH HOH A . 
J 4 HOH 93  493 537 HOH HOH A . 
J 4 HOH 94  494 180 HOH HOH A . 
J 4 HOH 95  495 290 HOH HOH A . 
J 4 HOH 96  496 722 HOH HOH A . 
J 4 HOH 97  497 449 HOH HOH A . 
J 4 HOH 98  498 359 HOH HOH A . 
J 4 HOH 99  499 59  HOH HOH A . 
J 4 HOH 100 500 318 HOH HOH A . 
J 4 HOH 101 501 361 HOH HOH A . 
J 4 HOH 102 502 151 HOH HOH A . 
J 4 HOH 103 503 19  HOH HOH A . 
J 4 HOH 104 504 573 HOH HOH A . 
J 4 HOH 105 505 68  HOH HOH A . 
J 4 HOH 106 506 128 HOH HOH A . 
J 4 HOH 107 507 437 HOH HOH A . 
J 4 HOH 108 508 307 HOH HOH A . 
J 4 HOH 109 509 154 HOH HOH A . 
J 4 HOH 110 510 638 HOH HOH A . 
J 4 HOH 111 511 48  HOH HOH A . 
J 4 HOH 112 512 70  HOH HOH A . 
J 4 HOH 113 513 187 HOH HOH A . 
J 4 HOH 114 514 103 HOH HOH A . 
J 4 HOH 115 515 49  HOH HOH A . 
J 4 HOH 116 516 20  HOH HOH A . 
J 4 HOH 117 517 104 HOH HOH A . 
J 4 HOH 118 518 438 HOH HOH A . 
J 4 HOH 119 519 464 HOH HOH A . 
J 4 HOH 120 520 5   HOH HOH A . 
J 4 HOH 121 521 439 HOH HOH A . 
J 4 HOH 122 522 23  HOH HOH A . 
J 4 HOH 123 523 62  HOH HOH A . 
J 4 HOH 124 524 163 HOH HOH A . 
J 4 HOH 125 525 641 HOH HOH A . 
J 4 HOH 126 526 266 HOH HOH A . 
J 4 HOH 127 527 441 HOH HOH A . 
J 4 HOH 128 528 642 HOH HOH A . 
J 4 HOH 129 529 633 HOH HOH A . 
J 4 HOH 130 530 330 HOH HOH A . 
J 4 HOH 131 531 109 HOH HOH A . 
J 4 HOH 132 532 191 HOH HOH A . 
J 4 HOH 133 533 490 HOH HOH A . 
J 4 HOH 134 534 203 HOH HOH A . 
J 4 HOH 135 535 115 HOH HOH A . 
J 4 HOH 136 536 445 HOH HOH A . 
J 4 HOH 137 537 178 HOH HOH A . 
J 4 HOH 138 538 534 HOH HOH A . 
J 4 HOH 139 539 510 HOH HOH A . 
J 4 HOH 140 540 252 HOH HOH A . 
J 4 HOH 141 541 251 HOH HOH A . 
J 4 HOH 142 542 262 HOH HOH A . 
J 4 HOH 143 543 131 HOH HOH A . 
J 4 HOH 144 544 1   HOH HOH A . 
J 4 HOH 145 545 530 HOH HOH A . 
J 4 HOH 146 546 100 HOH HOH A . 
J 4 HOH 147 547 692 HOH HOH A . 
J 4 HOH 148 548 436 HOH HOH A . 
J 4 HOH 149 549 612 HOH HOH A . 
J 4 HOH 150 550 121 HOH HOH A . 
J 4 HOH 151 551 150 HOH HOH A . 
J 4 HOH 152 552 758 HOH HOH A . 
J 4 HOH 153 553 803 HOH HOH A . 
J 4 HOH 154 554 140 HOH HOH A . 
J 4 HOH 155 555 643 HOH HOH A . 
J 4 HOH 156 556 801 HOH HOH A . 
J 4 HOH 157 557 589 HOH HOH A . 
J 4 HOH 158 558 329 HOH HOH A . 
J 4 HOH 159 559 634 HOH HOH A . 
J 4 HOH 160 560 355 HOH HOH A . 
J 4 HOH 161 561 167 HOH HOH A . 
J 4 HOH 162 562 442 HOH HOH A . 
J 4 HOH 163 563 527 HOH HOH A . 
J 4 HOH 164 564 487 HOH HOH A . 
J 4 HOH 165 565 69  HOH HOH A . 
J 4 HOH 166 566 583 HOH HOH A . 
J 4 HOH 167 567 749 HOH HOH A . 
J 4 HOH 168 568 120 HOH HOH A . 
J 4 HOH 169 569 605 HOH HOH A . 
J 4 HOH 170 570 652 HOH HOH A . 
J 4 HOH 171 571 509 HOH HOH A . 
J 4 HOH 172 572 531 HOH HOH A . 
J 4 HOH 173 573 341 HOH HOH A . 
J 4 HOH 174 574 591 HOH HOH A . 
J 4 HOH 175 575 106 HOH HOH A . 
J 4 HOH 176 576 21  HOH HOH A . 
J 4 HOH 177 577 56  HOH HOH A . 
J 4 HOH 178 578 396 HOH HOH A . 
J 4 HOH 179 579 482 HOH HOH A . 
J 4 HOH 180 580 456 HOH HOH A . 
J 4 HOH 181 581 156 HOH HOH A . 
J 4 HOH 182 582 458 HOH HOH A . 
J 4 HOH 183 583 188 HOH HOH A . 
J 4 HOH 184 584 808 HOH HOH A . 
J 4 HOH 185 585 138 HOH HOH A . 
J 4 HOH 186 586 716 HOH HOH A . 
J 4 HOH 187 587 662 HOH HOH A . 
J 4 HOH 188 588 270 HOH HOH A . 
J 4 HOH 189 589 54  HOH HOH A . 
J 4 HOH 190 590 64  HOH HOH A . 
J 4 HOH 191 591 305 HOH HOH A . 
J 4 HOH 192 592 411 HOH HOH A . 
J 4 HOH 193 593 76  HOH HOH A . 
J 4 HOH 194 594 285 HOH HOH A . 
J 4 HOH 195 595 314 HOH HOH A . 
J 4 HOH 196 596 79  HOH HOH A . 
J 4 HOH 197 597 600 HOH HOH A . 
J 4 HOH 198 598 86  HOH HOH A . 
J 4 HOH 199 599 383 HOH HOH A . 
J 4 HOH 200 600 345 HOH HOH A . 
J 4 HOH 201 601 289 HOH HOH A . 
J 4 HOH 202 602 459 HOH HOH A . 
J 4 HOH 203 603 25  HOH HOH A . 
J 4 HOH 204 604 205 HOH HOH A . 
J 4 HOH 205 605 204 HOH HOH A . 
J 4 HOH 206 606 440 HOH HOH A . 
J 4 HOH 207 607 674 HOH HOH A . 
J 4 HOH 208 608 328 HOH HOH A . 
J 4 HOH 209 609 173 HOH HOH A . 
J 4 HOH 210 610 261 HOH HOH A . 
J 4 HOH 211 611 184 HOH HOH A . 
J 4 HOH 212 612 623 HOH HOH A . 
J 4 HOH 213 613 477 HOH HOH A . 
J 4 HOH 214 614 680 HOH HOH A . 
J 4 HOH 215 615 698 HOH HOH A . 
J 4 HOH 216 616 306 HOH HOH A . 
J 4 HOH 217 617 82  HOH HOH A . 
J 4 HOH 218 618 500 HOH HOH A . 
J 4 HOH 219 619 253 HOH HOH A . 
J 4 HOH 220 620 72  HOH HOH A . 
J 4 HOH 221 621 632 HOH HOH A . 
J 4 HOH 222 622 297 HOH HOH A . 
J 4 HOH 223 623 514 HOH HOH A . 
J 4 HOH 224 624 679 HOH HOH A . 
J 4 HOH 225 625 468 HOH HOH A . 
J 4 HOH 226 626 717 HOH HOH A . 
J 4 HOH 227 627 71  HOH HOH A . 
J 4 HOH 228 628 358 HOH HOH A . 
J 4 HOH 229 629 127 HOH HOH A . 
J 4 HOH 230 630 705 HOH HOH A . 
J 4 HOH 231 631 107 HOH HOH A . 
J 4 HOH 232 632 700 HOH HOH A . 
J 4 HOH 233 633 804 HOH HOH A . 
J 4 HOH 234 634 122 HOH HOH A . 
J 4 HOH 235 635 443 HOH HOH A . 
J 4 HOH 236 636 650 HOH HOH A . 
J 4 HOH 237 637 255 HOH HOH A . 
J 4 HOH 238 638 648 HOH HOH A . 
J 4 HOH 239 639 17  HOH HOH A . 
J 4 HOH 240 640 488 HOH HOH A . 
J 4 HOH 241 641 463 HOH HOH A . 
J 4 HOH 242 642 746 HOH HOH A . 
J 4 HOH 243 643 614 HOH HOH A . 
J 4 HOH 244 644 453 HOH HOH A . 
J 4 HOH 245 645 105 HOH HOH A . 
J 4 HOH 246 646 452 HOH HOH A . 
J 4 HOH 247 647 551 HOH HOH A . 
J 4 HOH 248 648 471 HOH HOH A . 
J 4 HOH 249 649 277 HOH HOH A . 
J 4 HOH 250 650 338 HOH HOH A . 
J 4 HOH 251 651 777 HOH HOH A . 
J 4 HOH 252 652 687 HOH HOH A . 
J 4 HOH 253 653 675 HOH HOH A . 
J 4 HOH 254 654 269 HOH HOH A . 
J 4 HOH 255 655 360 HOH HOH A . 
J 4 HOH 256 656 569 HOH HOH A . 
J 4 HOH 257 657 428 HOH HOH A . 
J 4 HOH 258 658 625 HOH HOH A . 
J 4 HOH 259 659 357 HOH HOH A . 
J 4 HOH 260 660 596 HOH HOH A . 
J 4 HOH 261 661 322 HOH HOH A . 
J 4 HOH 262 662 108 HOH HOH A . 
J 4 HOH 263 663 432 HOH HOH A . 
J 4 HOH 264 664 570 HOH HOH A . 
J 4 HOH 265 665 139 HOH HOH A . 
J 4 HOH 266 666 794 HOH HOH A . 
J 4 HOH 267 667 391 HOH HOH A . 
J 4 HOH 268 668 699 HOH HOH A . 
J 4 HOH 269 669 665 HOH HOH A . 
J 4 HOH 270 670 326 HOH HOH A . 
J 4 HOH 271 671 772 HOH HOH A . 
J 4 HOH 272 672 647 HOH HOH A . 
J 4 HOH 273 673 603 HOH HOH A . 
J 4 HOH 274 674 734 HOH HOH A . 
J 4 HOH 275 675 659 HOH HOH A . 
J 4 HOH 276 676 235 HOH HOH A . 
J 4 HOH 277 677 672 HOH HOH A . 
J 4 HOH 278 678 286 HOH HOH A . 
J 4 HOH 279 679 486 HOH HOH A . 
J 4 HOH 280 680 135 HOH HOH A . 
J 4 HOH 281 681 593 HOH HOH A . 
J 4 HOH 282 682 585 HOH HOH A . 
J 4 HOH 283 683 685 HOH HOH A . 
J 4 HOH 284 684 581 HOH HOH A . 
J 4 HOH 285 685 744 HOH HOH A . 
J 4 HOH 286 686 663 HOH HOH A . 
J 4 HOH 287 687 571 HOH HOH A . 
J 4 HOH 288 688 753 HOH HOH A . 
J 4 HOH 289 689 542 HOH HOH A . 
J 4 HOH 290 690 750 HOH HOH A . 
J 4 HOH 291 691 415 HOH HOH A . 
J 4 HOH 292 692 273 HOH HOH A . 
J 4 HOH 293 693 684 HOH HOH A . 
J 4 HOH 294 694 792 HOH HOH A . 
J 4 HOH 295 695 543 HOH HOH A . 
J 4 HOH 296 696 472 HOH HOH A . 
J 4 HOH 297 697 791 HOH HOH A . 
J 4 HOH 298 698 757 HOH HOH A . 
J 4 HOH 299 699 264 HOH HOH A . 
J 4 HOH 300 700 616 HOH HOH A . 
J 4 HOH 301 701 144 HOH HOH A . 
J 4 HOH 302 702 694 HOH HOH A . 
J 4 HOH 303 703 349 HOH HOH A . 
J 4 HOH 304 704 725 HOH HOH A . 
J 4 HOH 305 705 676 HOH HOH A . 
J 4 HOH 306 706 420 HOH HOH A . 
J 4 HOH 307 707 324 HOH HOH A . 
J 4 HOH 308 708 754 HOH HOH A . 
J 4 HOH 309 709 299 HOH HOH A . 
J 4 HOH 310 710 461 HOH HOH A . 
J 4 HOH 311 711 547 HOH HOH A . 
J 4 HOH 312 712 688 HOH HOH A . 
J 4 HOH 313 713 654 HOH HOH A . 
J 4 HOH 314 714 599 HOH HOH A . 
J 4 HOH 315 715 783 HOH HOH A . 
J 4 HOH 316 716 572 HOH HOH A . 
J 4 HOH 317 717 740 HOH HOH A . 
J 4 HOH 318 718 549 HOH HOH A . 
J 4 HOH 319 719 212 HOH HOH A . 
J 4 HOH 320 720 419 HOH HOH A . 
J 4 HOH 321 721 210 HOH HOH A . 
J 4 HOH 322 722 759 HOH HOH A . 
J 4 HOH 323 723 615 HOH HOH A . 
J 4 HOH 324 724 789 HOH HOH A . 
J 4 HOH 325 725 703 HOH HOH A . 
J 4 HOH 326 726 683 HOH HOH A . 
J 4 HOH 327 727 539 HOH HOH A . 
J 4 HOH 328 728 238 HOH HOH A . 
J 4 HOH 329 729 291 HOH HOH A . 
J 4 HOH 330 730 516 HOH HOH A . 
J 4 HOH 331 731 481 HOH HOH A . 
J 4 HOH 332 732 426 HOH HOH A . 
J 4 HOH 333 733 385 HOH HOH A . 
J 4 HOH 334 734 669 HOH HOH A . 
J 4 HOH 335 735 611 HOH HOH A . 
J 4 HOH 336 736 479 HOH HOH A . 
J 4 HOH 337 737 498 HOH HOH A . 
J 4 HOH 338 738 762 HOH HOH A . 
J 4 HOH 339 739 624 HOH HOH A . 
J 4 HOH 340 740 413 HOH HOH A . 
J 4 HOH 341 741 201 HOH HOH A . 
J 4 HOH 342 742 771 HOH HOH A . 
J 4 HOH 343 743 776 HOH HOH A . 
J 4 HOH 344 744 657 HOH HOH A . 
J 4 HOH 345 745 196 HOH HOH A . 
J 4 HOH 346 746 97  HOH HOH A . 
J 4 HOH 347 747 560 HOH HOH A . 
J 4 HOH 348 748 219 HOH HOH A . 
J 4 HOH 349 749 737 HOH HOH A . 
J 4 HOH 350 750 224 HOH HOH A . 
J 4 HOH 351 751 293 HOH HOH A . 
J 4 HOH 352 752 409 HOH HOH A . 
J 4 HOH 353 753 677 HOH HOH A . 
J 4 HOH 354 754 606 HOH HOH A . 
J 4 HOH 355 755 327 HOH HOH A . 
J 4 HOH 356 756 412 HOH HOH A . 
J 4 HOH 357 757 484 HOH HOH A . 
J 4 HOH 358 758 528 HOH HOH A . 
J 4 HOH 359 759 673 HOH HOH A . 
J 4 HOH 360 760 515 HOH HOH A . 
J 4 HOH 361 761 607 HOH HOH A . 
J 4 HOH 362 762 424 HOH HOH A . 
J 4 HOH 363 763 334 HOH HOH A . 
J 4 HOH 364 764 177 HOH HOH A . 
J 4 HOH 365 765 434 HOH HOH A . 
J 4 HOH 366 766 283 HOH HOH A . 
J 4 HOH 367 767 631 HOH HOH A . 
J 4 HOH 368 768 786 HOH HOH A . 
J 4 HOH 369 769 541 HOH HOH A . 
J 4 HOH 370 770 576 HOH HOH A . 
J 4 HOH 371 771 407 HOH HOH A . 
J 4 HOH 372 772 566 HOH HOH A . 
J 4 HOH 373 773 714 HOH HOH A . 
J 4 HOH 374 774 748 HOH HOH A . 
J 4 HOH 375 775 473 HOH HOH A . 
J 4 HOH 376 776 767 HOH HOH A . 
J 4 HOH 377 777 496 HOH HOH A . 
J 4 HOH 378 778 406 HOH HOH A . 
J 4 HOH 379 779 568 HOH HOH A . 
J 4 HOH 380 780 470 HOH HOH A . 
J 4 HOH 381 781 739 HOH HOH A . 
J 4 HOH 382 782 346 HOH HOH A . 
J 4 HOH 383 783 506 HOH HOH A . 
J 4 HOH 384 784 475 HOH HOH A . 
J 4 HOH 385 785 536 HOH HOH A . 
J 4 HOH 386 786 608 HOH HOH A . 
J 4 HOH 387 787 696 HOH HOH A . 
J 4 HOH 388 788 145 HOH HOH A . 
J 4 HOH 389 789 504 HOH HOH A . 
J 4 HOH 390 790 724 HOH HOH A . 
J 4 HOH 391 791 431 HOH HOH A . 
J 4 HOH 392 792 602 HOH HOH A . 
J 4 HOH 393 793 429 HOH HOH A . 
J 4 HOH 394 794 723 HOH HOH A . 
J 4 HOH 395 795 367 HOH HOH A . 
J 4 HOH 396 796 381 HOH HOH A . 
J 4 HOH 397 797 752 HOH HOH A . 
J 4 HOH 398 798 257 HOH HOH A . 
J 4 HOH 399 799 433 HOH HOH A . 
K 4 HOH 1   401 802 HOH HOH B . 
K 4 HOH 2   402 211 HOH HOH B . 
K 4 HOH 3   403 664 HOH HOH B . 
K 4 HOH 4   404 790 HOH HOH B . 
K 4 HOH 5   405 317 HOH HOH B . 
K 4 HOH 6   406 95  HOH HOH B . 
K 4 HOH 7   407 362 HOH HOH B . 
K 4 HOH 8   408 129 HOH HOH B . 
K 4 HOH 9   409 710 HOH HOH B . 
K 4 HOH 10  410 240 HOH HOH B . 
K 4 HOH 11  411 548 HOH HOH B . 
K 4 HOH 12  412 485 HOH HOH B . 
K 4 HOH 13  413 195 HOH HOH B . 
K 4 HOH 14  414 194 HOH HOH B . 
K 4 HOH 15  415 300 HOH HOH B . 
K 4 HOH 16  416 92  HOH HOH B . 
K 4 HOH 17  417 695 HOH HOH B . 
K 4 HOH 18  418 28  HOH HOH B . 
K 4 HOH 19  419 132 HOH HOH B . 
K 4 HOH 20  420 656 HOH HOH B . 
K 4 HOH 21  421 50  HOH HOH B . 
K 4 HOH 22  422 497 HOH HOH B . 
K 4 HOH 23  423 379 HOH HOH B . 
K 4 HOH 24  424 745 HOH HOH B . 
K 4 HOH 25  425 347 HOH HOH B . 
K 4 HOH 26  426 193 HOH HOH B . 
K 4 HOH 27  427 370 HOH HOH B . 
K 4 HOH 28  428 511 HOH HOH B . 
K 4 HOH 29  429 161 HOH HOH B . 
K 4 HOH 30  430 215 HOH HOH B . 
K 4 HOH 31  431 620 HOH HOH B . 
K 4 HOH 32  432 87  HOH HOH B . 
K 4 HOH 33  433 691 HOH HOH B . 
K 4 HOH 34  434 91  HOH HOH B . 
K 4 HOH 35  435 706 HOH HOH B . 
K 4 HOH 36  436 101 HOH HOH B . 
K 4 HOH 37  437 629 HOH HOH B . 
K 4 HOH 38  438 287 HOH HOH B . 
K 4 HOH 39  439 718 HOH HOH B . 
K 4 HOH 40  440 133 HOH HOH B . 
K 4 HOH 41  441 147 HOH HOH B . 
K 4 HOH 42  442 351 HOH HOH B . 
K 4 HOH 43  443 304 HOH HOH B . 
K 4 HOH 44  444 371 HOH HOH B . 
K 4 HOH 45  445 797 HOH HOH B . 
K 4 HOH 46  446 399 HOH HOH B . 
K 4 HOH 47  447 81  HOH HOH B . 
K 4 HOH 48  448 342 HOH HOH B . 
K 4 HOH 49  449 690 HOH HOH B . 
K 4 HOH 50  450 756 HOH HOH B . 
K 4 HOH 51  451 323 HOH HOH B . 
K 4 HOH 52  452 113 HOH HOH B . 
K 4 HOH 53  453 7   HOH HOH B . 
K 4 HOH 54  454 13  HOH HOH B . 
K 4 HOH 55  455 558 HOH HOH B . 
K 4 HOH 56  456 170 HOH HOH B . 
K 4 HOH 57  457 225 HOH HOH B . 
K 4 HOH 58  458 176 HOH HOH B . 
K 4 HOH 59  459 6   HOH HOH B . 
K 4 HOH 60  460 88  HOH HOH B . 
K 4 HOH 61  461 41  HOH HOH B . 
K 4 HOH 62  462 451 HOH HOH B . 
K 4 HOH 63  463 353 HOH HOH B . 
K 4 HOH 64  464 313 HOH HOH B . 
K 4 HOH 65  465 171 HOH HOH B . 
K 4 HOH 66  466 38  HOH HOH B . 
K 4 HOH 67  467 701 HOH HOH B . 
K 4 HOH 68  468 60  HOH HOH B . 
K 4 HOH 69  469 356 HOH HOH B . 
K 4 HOH 70  470 53  HOH HOH B . 
K 4 HOH 71  471 321 HOH HOH B . 
K 4 HOH 72  472 43  HOH HOH B . 
K 4 HOH 73  473 609 HOH HOH B . 
K 4 HOH 74  474 231 HOH HOH B . 
K 4 HOH 75  475 502 HOH HOH B . 
K 4 HOH 76  476 405 HOH HOH B . 
K 4 HOH 77  477 58  HOH HOH B . 
K 4 HOH 78  478 535 HOH HOH B . 
K 4 HOH 79  479 552 HOH HOH B . 
K 4 HOH 80  480 198 HOH HOH B . 
K 4 HOH 81  481 214 HOH HOH B . 
K 4 HOH 82  482 258 HOH HOH B . 
K 4 HOH 83  483 31  HOH HOH B . 
K 4 HOH 84  484 74  HOH HOH B . 
K 4 HOH 85  485 24  HOH HOH B . 
K 4 HOH 86  486 268 HOH HOH B . 
K 4 HOH 87  487 671 HOH HOH B . 
K 4 HOH 88  488 8   HOH HOH B . 
K 4 HOH 89  489 344 HOH HOH B . 
K 4 HOH 90  490 77  HOH HOH B . 
K 4 HOH 91  491 114 HOH HOH B . 
K 4 HOH 92  492 61  HOH HOH B . 
K 4 HOH 93  493 169 HOH HOH B . 
K 4 HOH 94  494 42  HOH HOH B . 
K 4 HOH 95  495 221 HOH HOH B . 
K 4 HOH 96  496 288 HOH HOH B . 
K 4 HOH 97  497 182 HOH HOH B . 
K 4 HOH 98  498 33  HOH HOH B . 
K 4 HOH 99  499 10  HOH HOH B . 
K 4 HOH 100 500 640 HOH HOH B . 
K 4 HOH 101 501 732 HOH HOH B . 
K 4 HOH 102 502 380 HOH HOH B . 
K 4 HOH 103 503 518 HOH HOH B . 
K 4 HOH 104 504 308 HOH HOH B . 
K 4 HOH 105 505 36  HOH HOH B . 
K 4 HOH 106 506 34  HOH HOH B . 
K 4 HOH 107 507 152 HOH HOH B . 
K 4 HOH 108 508 256 HOH HOH B . 
K 4 HOH 109 509 244 HOH HOH B . 
K 4 HOH 110 510 4   HOH HOH B . 
K 4 HOH 111 511 340 HOH HOH B . 
K 4 HOH 112 512 228 HOH HOH B . 
K 4 HOH 113 513 727 HOH HOH B . 
K 4 HOH 114 514 46  HOH HOH B . 
K 4 HOH 115 515 168 HOH HOH B . 
K 4 HOH 116 516 126 HOH HOH B . 
K 4 HOH 117 517 460 HOH HOH B . 
K 4 HOH 118 518 720 HOH HOH B . 
K 4 HOH 119 519 30  HOH HOH B . 
K 4 HOH 120 520 400 HOH HOH B . 
K 4 HOH 121 521 526 HOH HOH B . 
K 4 HOH 122 522 206 HOH HOH B . 
K 4 HOH 123 523 162 HOH HOH B . 
K 4 HOH 124 524 781 HOH HOH B . 
K 4 HOH 125 525 27  HOH HOH B . 
K 4 HOH 126 526 259 HOH HOH B . 
K 4 HOH 127 527 192 HOH HOH B . 
K 4 HOH 128 528 733 HOH HOH B . 
K 4 HOH 129 529 14  HOH HOH B . 
K 4 HOH 130 530 637 HOH HOH B . 
K 4 HOH 131 531 63  HOH HOH B . 
K 4 HOH 132 532 26  HOH HOH B . 
K 4 HOH 133 533 806 HOH HOH B . 
K 4 HOH 134 534 260 HOH HOH B . 
K 4 HOH 135 535 272 HOH HOH B . 
K 4 HOH 136 536 316 HOH HOH B . 
K 4 HOH 137 537 249 HOH HOH B . 
K 4 HOH 138 538 649 HOH HOH B . 
K 4 HOH 139 539 731 HOH HOH B . 
K 4 HOH 140 540 55  HOH HOH B . 
K 4 HOH 141 541 263 HOH HOH B . 
K 4 HOH 142 542 190 HOH HOH B . 
K 4 HOH 143 543 372 HOH HOH B . 
K 4 HOH 144 544 332 HOH HOH B . 
K 4 HOH 145 545 112 HOH HOH B . 
K 4 HOH 146 546 124 HOH HOH B . 
K 4 HOH 147 547 298 HOH HOH B . 
K 4 HOH 148 548 119 HOH HOH B . 
K 4 HOH 149 549 499 HOH HOH B . 
K 4 HOH 150 550 507 HOH HOH B . 
K 4 HOH 151 551 495 HOH HOH B . 
K 4 HOH 152 552 562 HOH HOH B . 
K 4 HOH 153 553 35  HOH HOH B . 
K 4 HOH 154 554 729 HOH HOH B . 
K 4 HOH 155 555 146 HOH HOH B . 
K 4 HOH 156 556 503 HOH HOH B . 
K 4 HOH 157 557 376 HOH HOH B . 
K 4 HOH 158 558 175 HOH HOH B . 
K 4 HOH 159 559 12  HOH HOH B . 
K 4 HOH 160 560 160 HOH HOH B . 
K 4 HOH 161 561 93  HOH HOH B . 
K 4 HOH 162 562 557 HOH HOH B . 
K 4 HOH 163 563 565 HOH HOH B . 
K 4 HOH 164 564 185 HOH HOH B . 
K 4 HOH 165 565 590 HOH HOH B . 
K 4 HOH 166 566 111 HOH HOH B . 
K 4 HOH 167 567 595 HOH HOH B . 
K 4 HOH 168 568 795 HOH HOH B . 
K 4 HOH 169 569 57  HOH HOH B . 
K 4 HOH 170 570 78  HOH HOH B . 
K 4 HOH 171 571 18  HOH HOH B . 
K 4 HOH 172 572 179 HOH HOH B . 
K 4 HOH 173 573 186 HOH HOH B . 
K 4 HOH 174 574 234 HOH HOH B . 
K 4 HOH 175 575 601 HOH HOH B . 
K 4 HOH 176 576 769 HOH HOH B . 
K 4 HOH 177 577 117 HOH HOH B . 
K 4 HOH 178 578 230 HOH HOH B . 
K 4 HOH 179 579 157 HOH HOH B . 
K 4 HOH 180 580 137 HOH HOH B . 
K 4 HOH 181 581 199 HOH HOH B . 
K 4 HOH 182 582 98  HOH HOH B . 
K 4 HOH 183 583 563 HOH HOH B . 
K 4 HOH 184 584 697 HOH HOH B . 
K 4 HOH 185 585 284 HOH HOH B . 
K 4 HOH 186 586 9   HOH HOH B . 
K 4 HOH 187 587 368 HOH HOH B . 
K 4 HOH 188 588 303 HOH HOH B . 
K 4 HOH 189 589 118 HOH HOH B . 
K 4 HOH 190 590 44  HOH HOH B . 
K 4 HOH 191 591 148 HOH HOH B . 
K 4 HOH 192 592 22  HOH HOH B . 
K 4 HOH 193 593 207 HOH HOH B . 
K 4 HOH 194 594 197 HOH HOH B . 
K 4 HOH 195 595 582 HOH HOH B . 
K 4 HOH 196 596 519 HOH HOH B . 
K 4 HOH 197 597 742 HOH HOH B . 
K 4 HOH 198 598 45  HOH HOH B . 
K 4 HOH 199 599 216 HOH HOH B . 
K 4 HOH 200 600 248 HOH HOH B . 
K 4 HOH 201 601 743 HOH HOH B . 
K 4 HOH 202 602 142 HOH HOH B . 
K 4 HOH 203 603 94  HOH HOH B . 
K 4 HOH 204 604 166 HOH HOH B . 
K 4 HOH 205 605 73  HOH HOH B . 
K 4 HOH 206 606 217 HOH HOH B . 
K 4 HOH 207 607 736 HOH HOH B . 
K 4 HOH 208 608 159 HOH HOH B . 
K 4 HOH 209 609 807 HOH HOH B . 
K 4 HOH 210 610 636 HOH HOH B . 
K 4 HOH 211 611 226 HOH HOH B . 
K 4 HOH 212 612 123 HOH HOH B . 
K 4 HOH 213 613 183 HOH HOH B . 
K 4 HOH 214 614 280 HOH HOH B . 
K 4 HOH 215 615 704 HOH HOH B . 
K 4 HOH 216 616 52  HOH HOH B . 
K 4 HOH 217 617 237 HOH HOH B . 
K 4 HOH 218 618 693 HOH HOH B . 
K 4 HOH 219 619 702 HOH HOH B . 
K 4 HOH 220 620 586 HOH HOH B . 
K 4 HOH 221 621 278 HOH HOH B . 
K 4 HOH 222 622 513 HOH HOH B . 
K 4 HOH 223 623 310 HOH HOH B . 
K 4 HOH 224 624 377 HOH HOH B . 
K 4 HOH 225 625 747 HOH HOH B . 
K 4 HOH 226 626 155 HOH HOH B . 
K 4 HOH 227 627 39  HOH HOH B . 
K 4 HOH 228 628 604 HOH HOH B . 
K 4 HOH 229 629 265 HOH HOH B . 
K 4 HOH 230 630 798 HOH HOH B . 
K 4 HOH 231 631 292 HOH HOH B . 
K 4 HOH 232 632 765 HOH HOH B . 
K 4 HOH 233 633 243 HOH HOH B . 
K 4 HOH 234 634 301 HOH HOH B . 
K 4 HOH 235 635 520 HOH HOH B . 
K 4 HOH 236 636 579 HOH HOH B . 
K 4 HOH 237 637 350 HOH HOH B . 
K 4 HOH 238 638 628 HOH HOH B . 
K 4 HOH 239 639 779 HOH HOH B . 
K 4 HOH 240 640 529 HOH HOH B . 
K 4 HOH 241 641 796 HOH HOH B . 
K 4 HOH 242 642 476 HOH HOH B . 
K 4 HOH 243 643 728 HOH HOH B . 
K 4 HOH 244 644 246 HOH HOH B . 
K 4 HOH 245 645 279 HOH HOH B . 
K 4 HOH 246 646 489 HOH HOH B . 
K 4 HOH 247 647 462 HOH HOH B . 
K 4 HOH 248 648 425 HOH HOH B . 
K 4 HOH 249 649 275 HOH HOH B . 
K 4 HOH 250 650 339 HOH HOH B . 
K 4 HOH 251 651 587 HOH HOH B . 
K 4 HOH 252 652 711 HOH HOH B . 
K 4 HOH 253 653 713 HOH HOH B . 
K 4 HOH 254 654 626 HOH HOH B . 
K 4 HOH 255 655 202 HOH HOH B . 
K 4 HOH 256 656 577 HOH HOH B . 
K 4 HOH 257 657 467 HOH HOH B . 
K 4 HOH 258 658 556 HOH HOH B . 
K 4 HOH 259 659 768 HOH HOH B . 
K 4 HOH 260 660 751 HOH HOH B . 
K 4 HOH 261 661 627 HOH HOH B . 
K 4 HOH 262 662 775 HOH HOH B . 
K 4 HOH 263 663 267 HOH HOH B . 
K 4 HOH 264 664 229 HOH HOH B . 
K 4 HOH 265 665 658 HOH HOH B . 
K 4 HOH 266 666 621 HOH HOH B . 
K 4 HOH 267 667 508 HOH HOH B . 
K 4 HOH 268 668 125 HOH HOH B . 
K 4 HOH 269 669 337 HOH HOH B . 
K 4 HOH 270 670 782 HOH HOH B . 
K 4 HOH 271 671 540 HOH HOH B . 
K 4 HOH 272 672 787 HOH HOH B . 
K 4 HOH 273 673 149 HOH HOH B . 
K 4 HOH 274 674 544 HOH HOH B . 
K 4 HOH 275 675 501 HOH HOH B . 
K 4 HOH 276 676 617 HOH HOH B . 
K 4 HOH 277 677 661 HOH HOH B . 
K 4 HOH 278 678 546 HOH HOH B . 
K 4 HOH 279 679 312 HOH HOH B . 
K 4 HOH 280 680 352 HOH HOH B . 
K 4 HOH 281 681 805 HOH HOH B . 
K 4 HOH 282 682 553 HOH HOH B . 
K 4 HOH 283 683 763 HOH HOH B . 
K 4 HOH 284 684 331 HOH HOH B . 
K 4 HOH 285 685 417 HOH HOH B . 
K 4 HOH 286 686 721 HOH HOH B . 
K 4 HOH 287 687 250 HOH HOH B . 
K 4 HOH 288 688 218 HOH HOH B . 
K 4 HOH 289 689 242 HOH HOH B . 
K 4 HOH 290 690 630 HOH HOH B . 
K 4 HOH 291 691 655 HOH HOH B . 
K 4 HOH 292 692 153 HOH HOH B . 
K 4 HOH 293 693 773 HOH HOH B . 
K 4 HOH 294 694 635 HOH HOH B . 
K 4 HOH 295 695 610 HOH HOH B . 
K 4 HOH 296 696 386 HOH HOH B . 
K 4 HOH 297 697 384 HOH HOH B . 
K 4 HOH 298 698 404 HOH HOH B . 
K 4 HOH 299 699 213 HOH HOH B . 
K 4 HOH 300 700 281 HOH HOH B . 
K 4 HOH 301 701 209 HOH HOH B . 
K 4 HOH 302 702 457 HOH HOH B . 
K 4 HOH 303 703 378 HOH HOH B . 
K 4 HOH 304 704 653 HOH HOH B . 
K 4 HOH 305 705 799 HOH HOH B . 
K 4 HOH 306 706 245 HOH HOH B . 
K 4 HOH 307 707 764 HOH HOH B . 
K 4 HOH 308 708 578 HOH HOH B . 
K 4 HOH 309 709 254 HOH HOH B . 
K 4 HOH 310 710 668 HOH HOH B . 
K 4 HOH 311 711 401 HOH HOH B . 
K 4 HOH 312 712 719 HOH HOH B . 
K 4 HOH 313 713 96  HOH HOH B . 
K 4 HOH 314 714 584 HOH HOH B . 
K 4 HOH 315 715 678 HOH HOH B . 
K 4 HOH 316 716 738 HOH HOH B . 
K 4 HOH 317 717 164 HOH HOH B . 
K 4 HOH 318 718 597 HOH HOH B . 
K 4 HOH 319 719 707 HOH HOH B . 
K 4 HOH 320 720 726 HOH HOH B . 
K 4 HOH 321 721 421 HOH HOH B . 
K 4 HOH 322 722 784 HOH HOH B . 
K 4 HOH 323 723 295 HOH HOH B . 
K 4 HOH 324 724 708 HOH HOH B . 
K 4 HOH 325 725 335 HOH HOH B . 
K 4 HOH 326 726 408 HOH HOH B . 
K 4 HOH 327 727 594 HOH HOH B . 
K 4 HOH 328 728 223 HOH HOH B . 
K 4 HOH 329 729 402 HOH HOH B . 
K 4 HOH 330 730 522 HOH HOH B . 
K 4 HOH 331 731 660 HOH HOH B . 
K 4 HOH 332 732 517 HOH HOH B . 
K 4 HOH 333 733 670 HOH HOH B . 
K 4 HOH 334 734 561 HOH HOH B . 
K 4 HOH 335 735 715 HOH HOH B . 
K 4 HOH 336 736 365 HOH HOH B . 
K 4 HOH 337 737 200 HOH HOH B . 
K 4 HOH 338 738 580 HOH HOH B . 
K 4 HOH 339 739 130 HOH HOH B . 
K 4 HOH 340 740 427 HOH HOH B . 
K 4 HOH 341 741 554 HOH HOH B . 
K 4 HOH 342 742 158 HOH HOH B . 
K 4 HOH 343 743 730 HOH HOH B . 
K 4 HOH 344 744 319 HOH HOH B . 
K 4 HOH 345 745 521 HOH HOH B . 
K 4 HOH 346 746 422 HOH HOH B . 
K 4 HOH 347 747 682 HOH HOH B . 
K 4 HOH 348 748 369 HOH HOH B . 
K 4 HOH 349 749 800 HOH HOH B . 
K 4 HOH 350 750 533 HOH HOH B . 
K 4 HOH 351 751 99  HOH HOH B . 
K 4 HOH 352 752 75  HOH HOH B . 
K 4 HOH 353 753 403 HOH HOH B . 
K 4 HOH 354 754 480 HOH HOH B . 
K 4 HOH 355 755 512 HOH HOH B . 
K 4 HOH 356 756 741 HOH HOH B . 
K 4 HOH 357 757 241 HOH HOH B . 
K 4 HOH 358 758 172 HOH HOH B . 
K 4 HOH 359 759 780 HOH HOH B . 
K 4 HOH 360 760 232 HOH HOH B . 
K 4 HOH 361 761 375 HOH HOH B . 
K 4 HOH 362 762 778 HOH HOH B . 
K 4 HOH 363 763 494 HOH HOH B . 
K 4 HOH 364 764 85  HOH HOH B . 
K 4 HOH 365 765 785 HOH HOH B . 
K 4 HOH 366 766 388 HOH HOH B . 
K 4 HOH 367 767 622 HOH HOH B . 
K 4 HOH 368 768 387 HOH HOH B . 
K 4 HOH 369 769 793 HOH HOH B . 
K 4 HOH 370 770 336 HOH HOH B . 
K 4 HOH 371 771 414 HOH HOH B . 
K 4 HOH 372 772 523 HOH HOH B . 
K 4 HOH 373 773 363 HOH HOH B . 
K 4 HOH 374 774 559 HOH HOH B . 
K 4 HOH 375 775 689 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 ? 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XSCALE      ? ? ? .           ? 2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .           ? 3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .           ? 4 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? .           ? 5 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.32 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9OQE 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.180 
_cell.length_a_esd                 ? 
_cell.length_b                     106.610 
_cell.length_b_esd                 ? 
_cell.length_c                     47.710 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9OQE 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9OQE 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.01 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.95 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.9 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.4 M potassium phosphate, pH 7.9' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     'IMAGE PLATE' 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         RIGAKU 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2025-05-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.5418 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-E+' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.5418 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9OQE 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.5 
_reflns.d_resolution_low                               46.61 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     138574 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.34 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.10 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.989 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.112 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.5 
_reflns_shell.d_res_low                                     1.6 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             24441 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.36 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.73 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.586 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9OQE 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.50 
_refine.ls_d_res_low                             46.61 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     70245 
_refine.ls_number_reflns_R_free                  3508 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.84 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1493 
_refine.ls_R_factor_R_free                       0.1803 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1477 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.41 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.03 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.16 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.50 
_refine_hist.d_res_low                        46.61 
_refine_hist.number_atoms_solvent             774 
_refine_hist.number_atoms_total               4715 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3914 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         27 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.006 ? 4235 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 0.872 ? 5801 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 6.958 ? 618  ? f_dihedral_angle_d ? ? ? 
'X-RAY DIFFRACTION' ? 0.055 ? 672  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.010 ? 780  ? f_plane_restr      ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.50 1.52  . . 139 2637 100.00 . . . . 0.1961 . . . . . . . . . . . . . . . 0.2152 
'X-RAY DIFFRACTION' 1.52 1.54  . . 141 2675 100.00 . . . . 0.1854 . . . . . . . . . . . . . . . 0.2159 
'X-RAY DIFFRACTION' 1.54 1.57  . . 139 2653 100.00 . . . . 0.1786 . . . . . . . . . . . . . . . 0.2531 
'X-RAY DIFFRACTION' 1.57 1.59  . . 141 2671 100.00 . . . . 0.1858 . . . . . . . . . . . . . . . 0.2375 
'X-RAY DIFFRACTION' 1.59 1.62  . . 141 2673 100.00 . . . . 0.1961 . . . . . . . . . . . . . . . 0.2572 
'X-RAY DIFFRACTION' 1.62 1.64  . . 139 2670 100.00 . . . . 0.1926 . . . . . . . . . . . . . . . 0.2607 
'X-RAY DIFFRACTION' 1.64 1.67  . . 140 2653 100.00 . . . . 0.1783 . . . . . . . . . . . . . . . 0.2184 
'X-RAY DIFFRACTION' 1.67 1.71  . . 139 2663 100.00 . . . . 0.1676 . . . . . . . . . . . . . . . 0.1736 
'X-RAY DIFFRACTION' 1.71 1.74  . . 141 2671 100.00 . . . . 0.1664 . . . . . . . . . . . . . . . 0.2001 
'X-RAY DIFFRACTION' 1.74 1.78  . . 140 2661 100.00 . . . . 0.1580 . . . . . . . . . . . . . . . 0.2074 
'X-RAY DIFFRACTION' 1.78 1.82  . . 139 2704 100.00 . . . . 0.1512 . . . . . . . . . . . . . . . 0.1990 
'X-RAY DIFFRACTION' 1.82 1.87  . . 139 2643 100.00 . . . . 0.1474 . . . . . . . . . . . . . . . 0.1802 
'X-RAY DIFFRACTION' 1.87 1.92  . . 139 2660 100.00 . . . . 0.1533 . . . . . . . . . . . . . . . 0.1906 
'X-RAY DIFFRACTION' 1.92 1.97  . . 140 2660 99.00  . . . . 0.1559 . . . . . . . . . . . . . . . 0.1639 
'X-RAY DIFFRACTION' 1.97 2.04  . . 138 2629 100.00 . . . . 0.1589 . . . . . . . . . . . . . . . 0.1786 
'X-RAY DIFFRACTION' 2.04 2.11  . . 141 2676 100.00 . . . . 0.1454 . . . . . . . . . . . . . . . 0.1806 
'X-RAY DIFFRACTION' 2.11 2.19  . . 140 2660 99.00  . . . . 0.1439 . . . . . . . . . . . . . . . 0.1815 
'X-RAY DIFFRACTION' 2.19 2.29  . . 140 2674 100.00 . . . . 0.1439 . . . . . . . . . . . . . . . 0.1725 
'X-RAY DIFFRACTION' 2.29 2.41  . . 141 2666 100.00 . . . . 0.1467 . . . . . . . . . . . . . . . 0.1943 
'X-RAY DIFFRACTION' 2.41 2.56  . . 140 2670 100.00 . . . . 0.1501 . . . . . . . . . . . . . . . 0.1774 
'X-RAY DIFFRACTION' 2.56 2.76  . . 142 2686 100.00 . . . . 0.1486 . . . . . . . . . . . . . . . 0.2077 
'X-RAY DIFFRACTION' 2.76 3.04  . . 141 2685 100.00 . . . . 0.1392 . . . . . . . . . . . . . . . 0.1668 
'X-RAY DIFFRACTION' 3.04 3.48  . . 141 2678 100.00 . . . . 0.1320 . . . . . . . . . . . . . . . 0.1552 
'X-RAY DIFFRACTION' 3.48 4.38  . . 142 2692 100.00 . . . . 0.1139 . . . . . . . . . . . . . . . 0.1515 
'X-RAY DIFFRACTION' 4.39 46.61 . . 145 2727 100.00 . . . . 0.1393 . . . . . . . . . . . . . . . 0.1429 
# 
_struct.entry_id                     9OQE 
_struct.title                        'X-ray diffraction structure of apo-form CTX-M-14 beta-lactamase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9OQE 
_struct_keywords.text            'Enzyme, hydrolase, beta-lactamase' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 3 ? 
J N N 4 ? 
K N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9L5C7_ECOLX 
_struct_ref.pdbx_db_accession          Q9L5C7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNY
NPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRA
MAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQ
PQQNAESRRDVLASAARIIAEGL
;
_struct_ref.pdbx_align_begin           29 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9OQE A 1 ? 263 ? Q9L5C7 29 ? 291 ? 25 290 
2 1 9OQE B 1 ? 263 ? Q9L5C7 29 ? 291 ? 25 290 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,J   
2 1 B,F,G,H,I,K 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 4   ? GLY A 17  ? ALA A 28  GLY A 41  1 ? 14 
HELX_P HELX_P2  AA2 CYS A 44  ? THR A 46  ? CYS A 69  THR A 71  5 ? 3  
HELX_P HELX_P3  AA3 SER A 47  ? GLU A 60  ? SER A 72  GLU A 85  1 ? 14 
HELX_P HELX_P4  AA4 GLN A 64  ? ASN A 67  ? GLN A 89  ASN A 92  5 ? 4  
HELX_P HELX_P5  AA5 LYS A 73  ? LEU A 77  ? LYS A 98  LEU A 102 5 ? 5  
HELX_P HELX_P6  AA6 ILE A 83  ? VAL A 88  ? ILE A 108 VAL A 113 5 ? 6  
HELX_P HELX_P7  AA7 LEU A 94  ? SER A 105 ? LEU A 119 SER A 130 1 ? 12 
HELX_P HELX_P8  AA8 ASP A 106 ? LEU A 117 ? ASP A 131 LEU A 142 1 ? 12 
HELX_P HELX_P9  AA9 GLY A 119 ? ILE A 130 ? GLY A 144 ILE A 155 1 ? 12 
HELX_P HELX_P10 AB1 PRO A 142 ? THR A 146 ? PRO A 167 THR A 171 5 ? 5  
HELX_P HELX_P11 AB2 THR A 157 ? LEU A 170 ? THR A 182 LEU A 195 1 ? 14 
HELX_P HELX_P12 AB3 GLY A 175 ? GLY A 188 ? GLY A 200 GLY A 213 1 ? 14 
HELX_P HELX_P13 AB4 SER A 195 ? LEU A 200 ? SER A 220 LEU A 225 5 ? 6  
HELX_P HELX_P14 AB5 ARG A 248 ? GLY A 262 ? ARG A 275 GLY A 289 1 ? 15 
HELX_P HELX_P15 AB6 SER B 3   ? GLY B 17  ? SER B 27  GLY B 41  1 ? 15 
HELX_P HELX_P16 AB7 THR B 46  ? GLU B 60  ? THR B 71  GLU B 85  1 ? 15 
HELX_P HELX_P17 AB8 GLN B 64  ? ASN B 67  ? GLN B 89  ASN B 92  5 ? 4  
HELX_P HELX_P18 AB9 LYS B 73  ? LEU B 77  ? LYS B 98  LEU B 102 5 ? 5  
HELX_P HELX_P19 AC1 ILE B 83  ? VAL B 88  ? ILE B 108 VAL B 113 5 ? 6  
HELX_P HELX_P20 AC2 LEU B 94  ? SER B 105 ? LEU B 119 SER B 130 1 ? 12 
HELX_P HELX_P21 AC3 ASP B 106 ? LEU B 117 ? ASP B 131 LEU B 142 1 ? 12 
HELX_P HELX_P22 AC4 GLY B 119 ? ILE B 130 ? GLY B 144 ILE B 155 1 ? 12 
HELX_P HELX_P23 AC5 PRO B 142 ? THR B 146 ? PRO B 167 THR B 171 5 ? 5  
HELX_P HELX_P24 AC6 THR B 157 ? LEU B 170 ? THR B 182 LEU B 195 1 ? 14 
HELX_P HELX_P25 AC7 GLY B 175 ? GLY B 188 ? GLY B 200 GLY B 213 1 ? 14 
HELX_P HELX_P26 AC8 SER B 195 ? LEU B 200 ? SER B 220 LEU B 225 5 ? 6  
HELX_P HELX_P27 AC9 ARG B 248 ? GLY B 262 ? ARG B 275 GLY B 289 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A GLY 213 O ? ? ? 1_555 E K   . K ? ? A GLY 238 A K   303 1_555 ? ? ? ? ? ? ? 2.604 ? ? 
metalc2  metalc ? ? E K   .   K ? ? ? 1_555 J HOH . O ? ? A K   303 A HOH 450 1_555 ? ? ? ? ? ? ? 2.676 ? ? 
metalc3  metalc ? ? E K   .   K ? ? ? 1_555 J HOH . O ? ? A K   303 A HOH 470 1_555 ? ? ? ? ? ? ? 2.974 ? ? 
metalc4  metalc ? ? E K   .   K ? ? ? 1_555 J HOH . O ? ? A K   303 A HOH 504 1_555 ? ? ? ? ? ? ? 2.776 ? ? 
metalc5  metalc ? ? E K   .   K ? ? ? 1_555 J HOH . O ? ? A K   303 A HOH 604 1_555 ? ? ? ? ? ? ? 2.541 ? ? 
metalc6  metalc ? ? B GLY 213 O ? ? ? 1_555 I K   . K ? ? B GLY 238 B K   304 1_555 ? ? ? ? ? ? ? 2.654 ? ? 
metalc7  metalc ? ? I K   .   K ? ? ? 1_555 K HOH . O ? ? B K   304 B HOH 441 1_555 ? ? ? ? ? ? ? 2.728 ? ? 
metalc8  metalc ? ? I K   .   K ? ? ? 1_555 K HOH . O ? ? B K   304 B HOH 473 1_555 ? ? ? ? ? ? ? 2.715 ? ? 
metalc9  metalc ? ? I K   .   K ? ? ? 1_555 K HOH . O ? ? B K   304 B HOH 494 1_555 ? ? ? ? ? ? ? 2.940 ? ? 
metalc10 metalc ? ? I K   .   K ? ? ? 1_555 K HOH . O ? ? B K   304 B HOH 635 1_555 ? ? ? ? ? ? ? 2.593 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O ? A GLY 213 ? A GLY 238 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 450 ? 1_555 73.1  ? 
2  O ? A GLY 213 ? A GLY 238 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 470 ? 1_555 80.2  ? 
3  O ? J HOH .   ? A HOH 450 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 470 ? 1_555 104.1 ? 
4  O ? A GLY 213 ? A GLY 238 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 504 ? 1_555 76.1  ? 
5  O ? J HOH .   ? A HOH 450 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 504 ? 1_555 143.8 ? 
6  O ? J HOH .   ? A HOH 470 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 504 ? 1_555 88.6  ? 
7  O ? A GLY 213 ? A GLY 238 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 604 ? 1_555 147.5 ? 
8  O ? J HOH .   ? A HOH 450 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 604 ? 1_555 86.3  ? 
9  O ? J HOH .   ? A HOH 470 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 604 ? 1_555 80.8  ? 
10 O ? J HOH .   ? A HOH 504 ? 1_555 K ? E K . ? A K 303 ? 1_555 O ? J HOH . ? A HOH 604 ? 1_555 129.5 ? 
11 O ? B GLY 213 ? B GLY 238 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 441 ? 1_555 72.2  ? 
12 O ? B GLY 213 ? B GLY 238 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 473 ? 1_555 78.6  ? 
13 O ? K HOH .   ? B HOH 441 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 473 ? 1_555 145.6 ? 
14 O ? B GLY 213 ? B GLY 238 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 494 ? 1_555 79.8  ? 
15 O ? K HOH .   ? B HOH 441 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 494 ? 1_555 102.7 ? 
16 O ? K HOH .   ? B HOH 473 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 494 ? 1_555 89.5  ? 
17 O ? B GLY 213 ? B GLY 238 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 635 ? 1_555 149.9 ? 
18 O ? K HOH .   ? B HOH 441 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 635 ? 1_555 90.3  ? 
19 O ? K HOH .   ? B HOH 473 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 635 ? 1_555 123.7 ? 
20 O ? K HOH .   ? B HOH 494 ? 1_555 K ? I K . ? B K 304 ? 1_555 O ? K HOH . ? B HOH 635 ? 1_555 80.5  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 141 A . ? GLU 166 A PRO 142 A ? PRO 167 A 1 6.47 
2 GLU 141 B . ? GLU 166 B PRO 142 B ? PRO 167 B 1 5.54 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 32  ? TYR A 35  ? GLN A 56  TYR A 60  
AA1 2 ARG A 19  ? ASP A 26  ? ARG A 43  ASP A 50  
AA1 3 LEU A 232 ? THR A 239 ? LEU A 259 THR A 266 
AA1 4 THR A 217 ? TRP A 225 ? THR A 243 TRP A 251 
AA1 5 THR A 205 ? GLY A 213 ? THR A 230 GLY A 238 
AA2 1 PHE A 41  ? PRO A 42  ? PHE A 66  PRO A 67  
AA2 2 THR A 155 ? THR A 156 ? THR A 180 THR A 181 
AA3 1 PRO A 69  ? ILE A 72  ? PRO A 94  ILE A 97  
AA3 2 GLY A 90  ? THR A 93  ? GLY A 115 THR A 118 
AA4 1 GLN B 32  ? TYR B 35  ? GLN B 56  TYR B 60  
AA4 2 ARG B 19  ? ASP B 26  ? ARG B 43  ASP B 50  
AA4 3 LEU B 232 ? THR B 239 ? LEU B 259 THR B 266 
AA4 4 THR B 217 ? TRP B 225 ? THR B 243 TRP B 251 
AA4 5 THR B 205 ? GLY B 213 ? THR B 230 GLY B 238 
AA5 1 PHE B 41  ? PRO B 42  ? PHE B 66  PRO B 67  
AA5 2 THR B 155 ? THR B 156 ? THR B 180 THR B 181 
AA6 1 PRO B 69  ? ILE B 72  ? PRO B 94  ILE B 97  
AA6 2 GLY B 90  ? THR B 93  ? GLY B 115 THR B 118 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 33  ? O VAL A 57  N LEU A 24  ? N LEU A 48  
AA1 2 3 N GLY A 21  ? N GLY A 45  O TYR A 237 ? O TYR A 264 
AA1 3 4 O LEU A 232 ? O LEU A 259 N ILE A 224 ? N ILE A 250 
AA1 4 5 O TRP A 225 ? O TRP A 251 N THR A 205 ? N THR A 230 
AA2 1 2 N PHE A 41  ? N PHE A 66  O THR A 156 ? O THR A 181 
AA3 1 2 N ILE A 72  ? N ILE A 97  O GLY A 90  ? O GLY A 115 
AA4 1 2 O TYR B 35  ? O TYR B 60  N VAL B 22  ? N VAL B 46  
AA4 2 3 N GLY B 21  ? N GLY B 45  O TYR B 237 ? O TYR B 264 
AA4 3 4 O LEU B 232 ? O LEU B 259 N ILE B 224 ? N ILE B 250 
AA4 4 5 O TRP B 225 ? O TRP B 251 N THR B 205 ? N THR B 230 
AA5 1 2 N PHE B 41  ? N PHE B 66  O THR B 156 ? O THR B 181 
AA6 1 2 N ILE B 72  ? N ILE B 97  O GLY B 90  ? O GLY B 115 
# 
_pdbx_entry_details.entry_id                   9OQE 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 69  ? ? 49.95   -136.91 
2 1 VAL A 103 ? ? -109.46 -133.15 
3 1 SER A 220 ? ? -105.79 -127.93 
4 1 CYS B 69  ? ? 47.02   -135.46 
5 1 VAL B 103 ? ? -113.14 -132.52 
6 1 SER B 220 ? ? -106.20 -126.56 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       775 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.07 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLN 25 ? A GLN 1 
2 1 Y 1 A THR 26 ? A THR 2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
K   K    K N N 183 
LEU N    N N N 184 
LEU CA   C N S 185 
LEU C    C N N 186 
LEU O    O N N 187 
LEU CB   C N N 188 
LEU CG   C N N 189 
LEU CD1  C N N 190 
LEU CD2  C N N 191 
LEU OXT  O N N 192 
LEU H    H N N 193 
LEU H2   H N N 194 
LEU HA   H N N 195 
LEU HB2  H N N 196 
LEU HB3  H N N 197 
LEU HG   H N N 198 
LEU HD11 H N N 199 
LEU HD12 H N N 200 
LEU HD13 H N N 201 
LEU HD21 H N N 202 
LEU HD22 H N N 203 
LEU HD23 H N N 204 
LEU HXT  H N N 205 
LYS N    N N N 206 
LYS CA   C N S 207 
LYS C    C N N 208 
LYS O    O N N 209 
LYS CB   C N N 210 
LYS CG   C N N 211 
LYS CD   C N N 212 
LYS CE   C N N 213 
LYS NZ   N N N 214 
LYS OXT  O N N 215 
LYS H    H N N 216 
LYS H2   H N N 217 
LYS HA   H N N 218 
LYS HB2  H N N 219 
LYS HB3  H N N 220 
LYS HG2  H N N 221 
LYS HG3  H N N 222 
LYS HD2  H N N 223 
LYS HD3  H N N 224 
LYS HE2  H N N 225 
LYS HE3  H N N 226 
LYS HZ1  H N N 227 
LYS HZ2  H N N 228 
LYS HZ3  H N N 229 
LYS HXT  H N N 230 
MET N    N N N 231 
MET CA   C N S 232 
MET C    C N N 233 
MET O    O N N 234 
MET CB   C N N 235 
MET CG   C N N 236 
MET SD   S N N 237 
MET CE   C N N 238 
MET OXT  O N N 239 
MET H    H N N 240 
MET H2   H N N 241 
MET HA   H N N 242 
MET HB2  H N N 243 
MET HB3  H N N 244 
MET HG2  H N N 245 
MET HG3  H N N 246 
MET HE1  H N N 247 
MET HE2  H N N 248 
MET HE3  H N N 249 
MET HXT  H N N 250 
PHE N    N N N 251 
PHE CA   C N S 252 
PHE C    C N N 253 
PHE O    O N N 254 
PHE CB   C N N 255 
PHE CG   C Y N 256 
PHE CD1  C Y N 257 
PHE CD2  C Y N 258 
PHE CE1  C Y N 259 
PHE CE2  C Y N 260 
PHE CZ   C Y N 261 
PHE OXT  O N N 262 
PHE H    H N N 263 
PHE H2   H N N 264 
PHE HA   H N N 265 
PHE HB2  H N N 266 
PHE HB3  H N N 267 
PHE HD1  H N N 268 
PHE HD2  H N N 269 
PHE HE1  H N N 270 
PHE HE2  H N N 271 
PHE HZ   H N N 272 
PHE HXT  H N N 273 
PO4 P    P N N 274 
PO4 O1   O N N 275 
PO4 O2   O N N 276 
PO4 O3   O N N 277 
PO4 O4   O N N 278 
PRO N    N N N 279 
PRO CA   C N S 280 
PRO C    C N N 281 
PRO O    O N N 282 
PRO CB   C N N 283 
PRO CG   C N N 284 
PRO CD   C N N 285 
PRO OXT  O N N 286 
PRO H    H N N 287 
PRO HA   H N N 288 
PRO HB2  H N N 289 
PRO HB3  H N N 290 
PRO HG2  H N N 291 
PRO HG3  H N N 292 
PRO HD2  H N N 293 
PRO HD3  H N N 294 
PRO HXT  H N N 295 
SER N    N N N 296 
SER CA   C N S 297 
SER C    C N N 298 
SER O    O N N 299 
SER CB   C N N 300 
SER OG   O N N 301 
SER OXT  O N N 302 
SER H    H N N 303 
SER H2   H N N 304 
SER HA   H N N 305 
SER HB2  H N N 306 
SER HB3  H N N 307 
SER HG   H N N 308 
SER HXT  H N N 309 
THR N    N N N 310 
THR CA   C N S 311 
THR C    C N N 312 
THR O    O N N 313 
THR CB   C N R 314 
THR OG1  O N N 315 
THR CG2  C N N 316 
THR OXT  O N N 317 
THR H    H N N 318 
THR H2   H N N 319 
THR HA   H N N 320 
THR HB   H N N 321 
THR HG1  H N N 322 
THR HG21 H N N 323 
THR HG22 H N N 324 
THR HG23 H N N 325 
THR HXT  H N N 326 
TRP N    N N N 327 
TRP CA   C N S 328 
TRP C    C N N 329 
TRP O    O N N 330 
TRP CB   C N N 331 
TRP CG   C Y N 332 
TRP CD1  C Y N 333 
TRP CD2  C Y N 334 
TRP NE1  N Y N 335 
TRP CE2  C Y N 336 
TRP CE3  C Y N 337 
TRP CZ2  C Y N 338 
TRP CZ3  C Y N 339 
TRP CH2  C Y N 340 
TRP OXT  O N N 341 
TRP H    H N N 342 
TRP H2   H N N 343 
TRP HA   H N N 344 
TRP HB2  H N N 345 
TRP HB3  H N N 346 
TRP HD1  H N N 347 
TRP HE1  H N N 348 
TRP HE3  H N N 349 
TRP HZ2  H N N 350 
TRP HZ3  H N N 351 
TRP HH2  H N N 352 
TRP HXT  H N N 353 
TYR N    N N N 354 
TYR CA   C N S 355 
TYR C    C N N 356 
TYR O    O N N 357 
TYR CB   C N N 358 
TYR CG   C Y N 359 
TYR CD1  C Y N 360 
TYR CD2  C Y N 361 
TYR CE1  C Y N 362 
TYR CE2  C Y N 363 
TYR CZ   C Y N 364 
TYR OH   O N N 365 
TYR OXT  O N N 366 
TYR H    H N N 367 
TYR H2   H N N 368 
TYR HA   H N N 369 
TYR HB2  H N N 370 
TYR HB3  H N N 371 
TYR HD1  H N N 372 
TYR HD2  H N N 373 
TYR HE1  H N N 374 
TYR HE2  H N N 375 
TYR HH   H N N 376 
TYR HXT  H N N 377 
VAL N    N N N 378 
VAL CA   C N S 379 
VAL C    C N N 380 
VAL O    O N N 381 
VAL CB   C N N 382 
VAL CG1  C N N 383 
VAL CG2  C N N 384 
VAL OXT  O N N 385 
VAL H    H N N 386 
VAL H2   H N N 387 
VAL HA   H N N 388 
VAL HB   H N N 389 
VAL HG11 H N N 390 
VAL HG12 H N N 391 
VAL HG13 H N N 392 
VAL HG21 H N N 393 
VAL HG22 H N N 394 
VAL HG23 H N N 395 
VAL HXT  H N N 396 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PO4 P   O1   doub N N 260 
PO4 P   O2   sing N N 261 
PO4 P   O3   sing N N 262 
PO4 P   O4   sing N N 263 
PRO N   CA   sing N N 264 
PRO N   CD   sing N N 265 
PRO N   H    sing N N 266 
PRO CA  C    sing N N 267 
PRO CA  CB   sing N N 268 
PRO CA  HA   sing N N 269 
PRO C   O    doub N N 270 
PRO C   OXT  sing N N 271 
PRO CB  CG   sing N N 272 
PRO CB  HB2  sing N N 273 
PRO CB  HB3  sing N N 274 
PRO CG  CD   sing N N 275 
PRO CG  HG2  sing N N 276 
PRO CG  HG3  sing N N 277 
PRO CD  HD2  sing N N 278 
PRO CD  HD3  sing N N 279 
PRO OXT HXT  sing N N 280 
SER N   CA   sing N N 281 
SER N   H    sing N N 282 
SER N   H2   sing N N 283 
SER CA  C    sing N N 284 
SER CA  CB   sing N N 285 
SER CA  HA   sing N N 286 
SER C   O    doub N N 287 
SER C   OXT  sing N N 288 
SER CB  OG   sing N N 289 
SER CB  HB2  sing N N 290 
SER CB  HB3  sing N N 291 
SER OG  HG   sing N N 292 
SER OXT HXT  sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Howard Hughes Medical Institute (HHMI)'           'United States' HHMI-EPI          1 
'National Science Foundation (NSF, United States)' 'United States' DMR-1548924       2 
'Department of Energy (DOE, United States)'        'United States' DE-FC02-02ER63421 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1YLT 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9OQE 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022134 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004834 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009380 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021454 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
K 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 3   ? -29.721 -3.691  -31.090 1.00 38.14 ? 27  SER A N   1 
ATOM   2    C CA  . SER A 1 3   ? -29.906 -3.828  -32.533 1.00 41.73 ? 27  SER A CA  1 
ATOM   3    C C   . SER A 1 3   ? -28.584 -3.713  -33.294 1.00 41.76 ? 27  SER A C   1 
ATOM   4    O O   . SER A 1 3   ? -27.872 -2.712  -33.170 1.00 39.35 ? 27  SER A O   1 
ATOM   5    C CB  . SER A 1 3   ? -30.891 -2.775  -33.046 1.00 33.46 ? 27  SER A CB  1 
ATOM   6    O OG  . SER A 1 3   ? -32.116 -2.835  -32.335 1.00 54.05 ? 27  SER A OG  1 
ATOM   7    N N   . ALA A 1 4   ? -28.268 -4.747  -34.080 1.00 25.52 ? 28  ALA A N   1 
ATOM   8    C CA  . ALA A 1 4   ? -27.071 -4.765  -34.923 1.00 20.45 ? 28  ALA A CA  1 
ATOM   9    C C   . ALA A 1 4   ? -25.792 -4.686  -34.089 1.00 16.49 ? 28  ALA A C   1 
ATOM   10   O O   . ALA A 1 4   ? -24.787 -4.109  -34.516 1.00 16.93 ? 28  ALA A O   1 
ATOM   11   C CB  . ALA A 1 4   ? -27.116 -3.640  -35.961 1.00 26.68 ? 28  ALA A CB  1 
ATOM   12   N N   . VAL A 1 5   ? -25.807 -5.320  -32.911 1.00 16.45 ? 29  VAL A N   1 
ATOM   13   C CA  . VAL A 1 5   ? -24.695 -5.166  -31.975 1.00 17.33 ? 29  VAL A CA  1 
ATOM   14   C C   . VAL A 1 5   ? -23.408 -5.716  -32.578 1.00 14.86 ? 29  VAL A C   1 
ATOM   15   O O   . VAL A 1 5   ? -22.325 -5.142  -32.397 1.00 14.51 ? 29  VAL A O   1 
ATOM   16   C CB  . VAL A 1 5   ? -25.026 -5.825  -30.620 1.00 15.22 ? 29  VAL A CB  1 
ATOM   17   C CG1 . VAL A 1 5   ? -25.303 -7.327  -30.767 1.00 22.00 ? 29  VAL A CG1 1 
ATOM   18   C CG2 . VAL A 1 5   ? -23.906 -5.575  -29.616 1.00 14.46 ? 29  VAL A CG2 1 
ATOM   19   N N   . GLN A 1 6   ? -23.506 -6.816  -33.330 1.00 14.82 ? 30  GLN A N   1 
ATOM   20   C CA  . GLN A 1 6   ? -22.322 -7.391  -33.962 1.00 13.42 ? 30  GLN A CA  1 
ATOM   21   C C   . GLN A 1 6   ? -21.716 -6.439  -34.985 1.00 15.79 ? 30  GLN A C   1 
ATOM   22   O O   . GLN A 1 6   ? -20.490 -6.276  -35.051 1.00 17.29 ? 30  GLN A O   1 
ATOM   23   C CB  . GLN A 1 6   ? -22.684 -8.718  -34.634 1.00 14.93 ? 30  GLN A CB  1 
ATOM   24   C CG  . GLN A 1 6   ? -22.877 -9.878  -33.667 1.00 14.54 ? 30  GLN A CG  1 
ATOM   25   C CD  . GLN A 1 6   ? -21.662 -10.126 -32.804 1.00 18.62 ? 30  GLN A CD  1 
ATOM   26   O OE1 . GLN A 1 6   ? -20.527 -10.116 -33.289 1.00 20.65 ? 30  GLN A OE1 1 
ATOM   27   N NE2 . GLN A 1 6   ? -21.893 -10.369 -31.525 1.00 17.69 ? 30  GLN A NE2 1 
ATOM   28   N N   . GLN A 1 7   ? -22.557 -5.862  -35.843 1.00 15.62 ? 31  GLN A N   1 
ATOM   29   C CA  . GLN A 1 7   ? -22.077 -4.880  -36.807 1.00 15.71 ? 31  GLN A CA  1 
ATOM   30   C C   . GLN A 1 7   ? -21.370 -3.726  -36.105 1.00 15.38 ? 31  GLN A C   1 
ATOM   31   O O   . GLN A 1 7   ? -20.297 -3.284  -36.541 1.00 14.26 ? 31  GLN A O   1 
ATOM   32   C CB  . GLN A 1 7   ? -23.248 -4.361  -37.646 1.00 18.70 ? 31  GLN A CB  1 
ATOM   33   C CG  . GLN A 1 7   ? -23.685 -5.295  -38.778 1.00 19.26 ? 31  GLN A CG  1 
ATOM   34   C CD  . GLN A 1 7   ? -25.077 -4.942  -39.300 1.00 18.08 ? 31  GLN A CD  1 
ATOM   35   O OE1 . GLN A 1 7   ? -26.059 -5.000  -38.562 1.00 21.20 ? 31  GLN A OE1 1 
ATOM   36   N NE2 . GLN A 1 7   ? -25.156 -4.553  -40.570 1.00 17.92 ? 31  GLN A NE2 1 
ATOM   37   N N   . LYS A 1 8   ? -21.936 -3.252  -34.996 1.00 14.74 ? 32  LYS A N   1 
ATOM   38   C CA  . LYS A 1 8   ? -21.382 -2.072  -34.342 1.00 13.86 ? 32  LYS A CA  1 
ATOM   39   C C   . LYS A 1 8   ? -20.051 -2.381  -33.664 1.00 14.65 ? 32  LYS A C   1 
ATOM   40   O O   . LYS A 1 8   ? -19.105 -1.578  -33.730 1.00 12.83 ? 32  LYS A O   1 
ATOM   41   C CB  . LYS A 1 8   ? -22.387 -1.521  -33.339 1.00 14.47 ? 32  LYS A CB  1 
ATOM   42   C CG  . LYS A 1 8   ? -23.684 -1.001  -33.993 1.00 14.05 ? 32  LYS A CG  1 
ATOM   43   C CD  . LYS A 1 8   ? -24.774 -0.776  -32.950 1.00 21.28 ? 32  LYS A CD  1 
ATOM   44   C CE  . LYS A 1 8   ? -25.786 0.275   -33.398 1.00 28.56 ? 32  LYS A CE  1 
ATOM   45   N NZ  . LYS A 1 8   ? -25.164 1.402   -34.155 1.00 37.43 ? 32  LYS A NZ  1 
ATOM   46   N N   . LEU A 1 9   ? -19.956 -3.542  -33.012 1.00 12.24 ? 33  LEU A N   1 
ATOM   47   C CA  . LEU A 1 9   ? -18.700 -3.915  -32.377 1.00 12.35 ? 33  LEU A CA  1 
ATOM   48   C C   . LEU A 1 9   ? -17.607 -4.155  -33.409 1.00 11.53 ? 33  LEU A C   1 
ATOM   49   O O   . LEU A 1 9   ? -16.460 -3.737  -33.212 1.00 11.81 ? 33  LEU A O   1 
ATOM   50   C CB  . LEU A 1 9   ? -18.898 -5.152  -31.499 1.00 13.60 ? 33  LEU A CB  1 
ATOM   51   C CG  . LEU A 1 9   ? -19.745 -4.896  -30.255 1.00 9.35  ? 33  LEU A CG  1 
ATOM   52   C CD1 . LEU A 1 9   ? -20.009 -6.227  -29.547 1.00 9.28  ? 33  LEU A CD1 1 
ATOM   53   C CD2 . LEU A 1 9   ? -19.048 -3.918  -29.301 1.00 12.25 ? 33  LEU A CD2 1 
ATOM   54   N N   . ALA A 1 10  ? -17.943 -4.821  -34.521 1.00 11.95 ? 34  ALA A N   1 
ATOM   55   C CA  . ALA A 1 10  ? -16.965 -5.014  -35.586 1.00 11.15 ? 34  ALA A CA  1 
ATOM   56   C C   . ALA A 1 10  ? -16.502 -3.680  -36.154 1.00 10.88 ? 34  ALA A C   1 
ATOM   57   O O   . ALA A 1 10  ? -15.309 -3.503  -36.443 1.00 11.46 ? 34  ALA A O   1 
ATOM   58   C CB  . ALA A 1 10  ? -17.559 -5.881  -36.697 1.00 13.59 ? 34  ALA A CB  1 
ATOM   59   N N   . ALA A 1 11  ? -17.432 -2.732  -36.305 1.00 12.22 ? 35  ALA A N   1 
ATOM   60   C CA  . ALA A 1 11  ? -17.072 -1.420  -36.838 1.00 14.38 ? 35  ALA A CA  1 
ATOM   61   C C   . ALA A 1 11  ? -16.180 -0.670  -35.864 1.00 14.33 ? 35  ALA A C   1 
ATOM   62   O O   . ALA A 1 11  ? -15.208 -0.019  -36.271 1.00 14.59 ? 35  ALA A O   1 
ATOM   63   C CB  . ALA A 1 11  ? -18.330 -0.616  -37.143 1.00 15.28 ? 35  ALA A CB  1 
ATOM   64   N N   . LEU A 1 12  ? -16.493 -0.764  -34.565 1.00 11.79 ? 36  LEU A N   1 
ATOM   65   C CA  . LEU A 1 12  ? -15.638 -0.130  -33.569 1.00 10.84 ? 36  LEU A CA  1 
ATOM   66   C C   . LEU A 1 12  ? -14.230 -0.707  -33.609 1.00 10.80 ? 36  LEU A C   1 
ATOM   67   O O   . LEU A 1 12  ? -13.247 0.038   -33.605 1.00 11.60 ? 36  LEU A O   1 
ATOM   68   C CB  . LEU A 1 12  ? -16.243 -0.299  -32.182 1.00 10.68 ? 36  LEU A CB  1 
ATOM   69   C CG  . LEU A 1 12  ? -15.342 0.070   -31.010 1.00 9.60  ? 36  LEU A CG  1 
ATOM   70   C CD1 . LEU A 1 12  ? -15.039 1.569   -31.018 1.00 11.34 ? 36  LEU A CD1 1 
ATOM   71   C CD2 . LEU A 1 12  ? -16.015 -0.333  -29.697 1.00 13.30 ? 36  LEU A CD2 1 
ATOM   72   N N   . GLU A 1 13  ? -14.115 -2.041  -33.690 1.00 10.70 ? 37  GLU A N   1 
ATOM   73   C CA  . GLU A 1 13  ? -12.797 -2.660  -33.760 1.00 12.33 ? 37  GLU A CA  1 
ATOM   74   C C   . GLU A 1 13  ? -12.029 -2.205  -34.998 1.00 10.41 ? 37  GLU A C   1 
ATOM   75   O O   . GLU A 1 13  ? -10.832 -1.913  -34.923 1.00 10.48 ? 37  GLU A O   1 
ATOM   76   C CB  . GLU A 1 13  ? -12.940 -4.180  -33.748 1.00 11.15 ? 37  GLU A CB  1 
ATOM   77   C CG  . GLU A 1 13  ? -11.626 -4.900  -33.903 1.00 11.22 ? 37  GLU A CG  1 
ATOM   78   C CD  . GLU A 1 13  ? -11.815 -6.389  -33.982 1.00 13.48 ? 37  GLU A CD  1 
ATOM   79   O OE1 . GLU A 1 13  ? -12.478 -6.859  -34.938 1.00 14.40 ? 37  GLU A OE1 1 
ATOM   80   O OE2 . GLU A 1 13  ? -11.333 -7.076  -33.059 1.00 13.06 ? 37  GLU A OE2 1 
ATOM   81   N N   . LYS A 1 14  ? -12.696 -2.163  -36.153 1.00 12.16 ? 38  LYS A N   1 
ATOM   82   C CA  . LYS A 1 14  ? -12.006 -1.767  -37.376 1.00 12.21 ? 38  LYS A CA  1 
ATOM   83   C C   . LYS A 1 14  ? -11.500 -0.338  -37.270 1.00 13.94 ? 38  LYS A C   1 
ATOM   84   O O   . LYS A 1 14  ? -10.364 -0.039  -37.664 1.00 14.83 ? 38  LYS A O   1 
ATOM   85   C CB  . LYS A 1 14  ? -12.944 -1.931  -38.573 1.00 15.29 ? 38  LYS A CB  1 
ATOM   86   C CG  . LYS A 1 14  ? -12.217 -2.122  -39.898 1.00 23.93 ? 38  LYS A CG  1 
ATOM   87   C CD  . LYS A 1 14  ? -13.138 -1.846  -41.076 1.00 33.77 ? 38  LYS A CD  1 
ATOM   88   C CE  . LYS A 1 14  ? -12.422 -1.014  -42.133 1.00 39.13 ? 38  LYS A CE  1 
ATOM   89   N NZ  . LYS A 1 14  ? -11.589 -1.871  -43.026 1.00 50.37 ? 38  LYS A NZ  1 
ATOM   90   N N   . SER A 1 15  ? -12.315 0.549   -36.696 1.00 12.46 ? 39  SER A N   1 
ATOM   91   C CA  . SER A 1 15  ? -11.889 1.936   -36.560 1.00 11.38 ? 39  SER A CA  1 
ATOM   92   C C   . SER A 1 15  ? -10.725 2.055   -35.585 1.00 12.39 ? 39  SER A C   1 
ATOM   93   O O   . SER A 1 15  ? -9.809  2.860   -35.797 1.00 13.90 ? 39  SER A O   1 
ATOM   94   C CB  . SER A 1 15  ? -13.073 2.784   -36.120 1.00 15.05 ? 39  SER A CB  1 
ATOM   95   O OG  . SER A 1 15  ? -12.656 4.062   -35.696 1.00 15.12 ? 39  SER A OG  1 
ATOM   96   N N   . SER A 1 16  ? -10.721 1.220   -34.538 1.00 11.04 ? 40  SER A N   1 
ATOM   97   C CA  . SER A 1 16  ? -9.674  1.244   -33.517 1.00 11.53 ? 40  SER A CA  1 
ATOM   98   C C   . SER A 1 16  ? -8.321  0.753   -34.017 1.00 11.31 ? 40  SER A C   1 
ATOM   99   O O   . SER A 1 16  ? -7.294  1.093   -33.418 1.00 12.80 ? 40  SER A O   1 
ATOM   100  C CB  . SER A 1 16  ? -10.089 0.380   -32.324 1.00 9.00  ? 40  SER A CB  1 
ATOM   101  O OG  . SER A 1 16  ? -9.866  -1.004  -32.623 1.00 10.95 ? 40  SER A OG  1 
ATOM   102  N N   . GLY A 1 17  ? -8.291  -0.069  -35.063 1.00 12.08 ? 41  GLY A N   1 
ATOM   103  C CA  . GLY A 1 17  ? -7.054  -0.644  -35.556 1.00 13.11 ? 41  GLY A CA  1 
ATOM   104  C C   . GLY A 1 17  ? -6.524  -1.829  -34.773 1.00 12.28 ? 41  GLY A C   1 
ATOM   105  O O   . GLY A 1 17  ? -5.493  -2.401  -35.162 1.00 16.79 ? 41  GLY A O   1 
ATOM   106  N N   . GLY A 1 18  ? -7.175  -2.208  -33.678 1.00 11.50 ? 42  GLY A N   1 
ATOM   107  C CA  . GLY A 1 18  ? -6.692  -3.304  -32.864 1.00 11.87 ? 42  GLY A CA  1 
ATOM   108  C C   . GLY A 1 18  ? -7.613  -4.510  -32.829 1.00 12.10 ? 42  GLY A C   1 
ATOM   109  O O   . GLY A 1 18  ? -8.344  -4.767  -33.790 1.00 11.58 ? 42  GLY A O   1 
ATOM   110  N N   . ARG A 1 19  ? -7.562  -5.267  -31.731 1.00 9.14  ? 43  ARG A N   1 
ATOM   111  C CA  . ARG A 1 19  ? -8.307  -6.511  -31.568 1.00 9.49  ? 43  ARG A CA  1 
ATOM   112  C C   . ARG A 1 19  ? -9.138  -6.392  -30.295 1.00 7.91  ? 43  ARG A C   1 
ATOM   113  O O   . ARG A 1 19  ? -8.586  -6.186  -29.206 1.00 9.73  ? 43  ARG A O   1 
ATOM   114  C CB  . ARG A 1 19  ? -7.364  -7.719  -31.513 1.00 10.39 ? 43  ARG A CB  1 
ATOM   115  C CG  . ARG A 1 19  ? -8.061  -9.069  -31.422 1.00 7.80  ? 43  ARG A CG  1 
ATOM   116  C CD  . ARG A 1 19  ? -7.095  -10.231 -31.562 1.00 9.47  ? 43  ARG A CD  1 
ATOM   117  N NE  . ARG A 1 19  ? -6.111  -10.327 -30.487 1.00 11.27 ? 43  ARG A NE  1 
ATOM   118  C CZ  . ARG A 1 19  ? -6.232  -11.139 -29.444 1.00 10.24 ? 43  ARG A CZ  1 
ATOM   119  N NH1 . ARG A 1 19  ? -7.287  -11.929 -29.301 1.00 10.76 ? 43  ARG A NH1 1 
ATOM   120  N NH2 . ARG A 1 19  ? -5.282  -11.149 -28.510 1.00 9.02  ? 43  ARG A NH2 1 
ATOM   121  N N   . LEU A 1 20  ? -10.447 -6.496  -30.445 1.00 7.81  ? 44  LEU A N   1 
ATOM   122  C CA  . LEU A 1 20  ? -11.411 -6.226  -29.387 1.00 7.45  ? 44  LEU A CA  1 
ATOM   123  C C   . LEU A 1 20  ? -12.099 -7.518  -28.980 1.00 9.89  ? 44  LEU A C   1 
ATOM   124  O O   . LEU A 1 20  ? -12.549 -8.281  -29.845 1.00 8.96  ? 44  LEU A O   1 
ATOM   125  C CB  . LEU A 1 20  ? -12.456 -5.217  -29.874 1.00 10.06 ? 44  LEU A CB  1 
ATOM   126  C CG  . LEU A 1 20  ? -13.607 -4.881  -28.925 1.00 9.21  ? 44  LEU A CG  1 
ATOM   127  C CD1 . LEU A 1 20  ? -13.128 -4.151  -27.665 1.00 8.85  ? 44  LEU A CD1 1 
ATOM   128  C CD2 . LEU A 1 20  ? -14.715 -4.091  -29.662 1.00 14.20 ? 44  LEU A CD2 1 
ATOM   129  N N   . GLY A 1 21  ? -12.204 -7.745  -27.668 1.00 8.97  ? 45  GLY A N   1 
ATOM   130  C CA  . GLY A 1 21  ? -12.934 -8.888  -27.149 1.00 8.53  ? 45  GLY A CA  1 
ATOM   131  C C   . GLY A 1 21  ? -13.973 -8.453  -26.148 1.00 9.39  ? 45  GLY A C   1 
ATOM   132  O O   . GLY A 1 21  ? -13.656 -7.697  -25.228 1.00 10.07 ? 45  GLY A O   1 
ATOM   133  N N   . VAL A 1 22  ? -15.219 -8.882  -26.329 1.00 6.17  ? 46  VAL A N   1 
ATOM   134  C CA  . VAL A 1 22  ? -16.324 -8.455  -25.481 1.00 7.48  ? 46  VAL A CA  1 
ATOM   135  C C   . VAL A 1 22  ? -17.076 -9.694  -25.027 1.00 8.37  ? 46  VAL A C   1 
ATOM   136  O O   . VAL A 1 22  ? -17.347 -10.595 -25.828 1.00 8.47  ? 46  VAL A O   1 
ATOM   137  C CB  . VAL A 1 22  ? -17.288 -7.498  -26.221 1.00 8.55  ? 46  VAL A CB  1 
ATOM   138  C CG1 . VAL A 1 22  ? -18.480 -7.119  -25.320 1.00 10.95 ? 46  VAL A CG1 1 
ATOM   139  C CG2 . VAL A 1 22  ? -16.555 -6.255  -26.714 1.00 8.84  ? 46  VAL A CG2 1 
ATOM   140  N N   . ALA A 1 23  ? -17.420 -9.751  -23.743 1.00 8.42  ? 47  ALA A N   1 
ATOM   141  C CA  . ALA A 1 23  ? -18.395 -10.731 -23.278 1.00 6.92  ? 47  ALA A CA  1 
ATOM   142  C C   . ALA A 1 23  ? -19.328 -10.064 -22.284 1.00 8.58  ? 47  ALA A C   1 
ATOM   143  O O   . ALA A 1 23  ? -18.885 -9.590  -21.234 1.00 9.60  ? 47  ALA A O   1 
ATOM   144  C CB  . ALA A 1 23  ? -17.722 -11.943 -22.642 1.00 12.10 ? 47  ALA A CB  1 
ATOM   145  N N   . LEU A 1 24  ? -20.613 -10.057 -22.609 1.00 7.37  ? 48  LEU A N   1 
ATOM   146  C CA  . LEU A 1 24  ? -21.669 -9.604  -21.716 1.00 11.40 ? 48  LEU A CA  1 
ATOM   147  C C   . LEU A 1 24  ? -22.464 -10.804 -21.217 1.00 10.48 ? 48  LEU A C   1 
ATOM   148  O O   . LEU A 1 24  ? -22.780 -11.707 -22.000 1.00 11.21 ? 48  LEU A O   1 
ATOM   149  C CB  . LEU A 1 24  ? -22.619 -8.636  -22.438 1.00 11.08 ? 48  LEU A CB  1 
ATOM   150  C CG  . LEU A 1 24  ? -23.943 -8.338  -21.720 1.00 13.61 ? 48  LEU A CG  1 
ATOM   151  C CD1 . LEU A 1 24  ? -23.741 -7.383  -20.536 1.00 14.91 ? 48  LEU A CD1 1 
ATOM   152  C CD2 . LEU A 1 24  ? -24.971 -7.787  -22.701 1.00 15.99 ? 48  LEU A CD2 1 
ATOM   153  N N   . ILE A 1 25  ? -22.804 -10.806 -19.924 1.00 10.00 ? 49  ILE A N   1 
ATOM   154  C CA  . ILE A 1 25  ? -23.851 -11.667 -19.376 1.00 9.04  ? 49  ILE A CA  1 
ATOM   155  C C   . ILE A 1 25  ? -24.915 -10.757 -18.783 1.00 12.01 ? 49  ILE A C   1 
ATOM   156  O O   . ILE A 1 25  ? -24.626 -9.963  -17.881 1.00 11.49 ? 49  ILE A O   1 
ATOM   157  C CB  . ILE A 1 25  ? -23.333 -12.636 -18.301 1.00 10.84 ? 49  ILE A CB  1 
ATOM   158  C CG1 . ILE A 1 25  ? -22.234 -13.543 -18.839 1.00 10.85 ? 49  ILE A CG1 1 
ATOM   159  C CG2 . ILE A 1 25  ? -24.464 -13.500 -17.760 1.00 12.49 ? 49  ILE A CG2 1 
ATOM   160  C CD1 . ILE A 1 25  ? -21.514 -14.289 -17.715 1.00 11.73 ? 49  ILE A CD1 1 
ATOM   161  N N   . ASP A 1 26  ? -26.136 -10.854 -19.290 1.00 12.22 ? 50  ASP A N   1 
ATOM   162  C CA  . ASP A 1 26  ? -27.263 -10.127 -18.728 1.00 14.78 ? 50  ASP A CA  1 
ATOM   163  C C   . ASP A 1 26  ? -27.991 -11.101 -17.815 1.00 17.50 ? 50  ASP A C   1 
ATOM   164  O O   . ASP A 1 26  ? -28.614 -12.048 -18.300 1.00 17.57 ? 50  ASP A O   1 
ATOM   165  C CB  . ASP A 1 26  ? -28.172 -9.612  -19.839 1.00 14.34 ? 50  ASP A CB  1 
ATOM   166  C CG  . ASP A 1 26  ? -29.318 -8.780  -19.314 1.00 21.79 ? 50  ASP A CG  1 
ATOM   167  O OD1 . ASP A 1 26  ? -29.548 -8.782  -18.086 1.00 19.11 ? 50  ASP A OD1 1 
ATOM   168  O OD2 . ASP A 1 26  ? -29.996 -8.136  -20.141 1.00 22.19 ? 50  ASP A OD2 1 
ATOM   169  N N   . THR A 1 27  ? -27.908 -10.885 -16.498 1.00 13.37 ? 51  THR A N   1 
ATOM   170  C CA  . THR A 1 27  ? -28.488 -11.863 -15.581 1.00 17.55 ? 51  THR A CA  1 
ATOM   171  C C   . THR A 1 27  ? -30.000 -11.721 -15.460 1.00 16.34 ? 51  THR A C   1 
ATOM   172  O O   . THR A 1 27  ? -30.621 -12.533 -14.769 1.00 22.84 ? 51  THR A O   1 
ATOM   173  C CB  . THR A 1 27  ? -27.852 -11.792 -14.182 1.00 17.30 ? 51  THR A CB  1 
ATOM   174  O OG1 . THR A 1 27  ? -28.288 -10.609 -13.490 1.00 16.74 ? 51  THR A OG1 1 
ATOM   175  C CG2 . THR A 1 27  ? -26.319 -11.818 -14.251 1.00 17.61 ? 51  THR A CG2 1 
ATOM   176  N N   . ALA A 1 28  ? -30.599 -10.727 -16.119 1.00 17.69 ? 52  ALA A N   1 
ATOM   177  C CA  . ALA A 1 28  ? -32.056 -10.655 -16.170 1.00 19.29 ? 52  ALA A CA  1 
ATOM   178  C C   . ALA A 1 28  ? -32.635 -11.892 -16.840 1.00 29.39 ? 52  ALA A C   1 
ATOM   179  O O   . ALA A 1 28  ? -33.671 -12.412 -16.413 1.00 23.96 ? 52  ALA A O   1 
ATOM   180  C CB  . ALA A 1 28  ? -32.502 -9.394  -16.907 1.00 21.49 ? 52  ALA A CB  1 
ATOM   181  N N   . ASP A 1 29  ? -31.962 -12.389 -17.880 1.00 23.20 ? 53  ASP A N   1 
ATOM   182  C CA  . ASP A 1 29  ? -32.471 -13.500 -18.674 1.00 21.84 ? 53  ASP A CA  1 
ATOM   183  C C   . ASP A 1 29  ? -31.366 -14.441 -19.142 1.00 22.07 ? 53  ASP A C   1 
ATOM   184  O O   . ASP A 1 29  ? -31.635 -15.316 -19.980 1.00 22.08 ? 53  ASP A O   1 
ATOM   185  C CB  . ASP A 1 29  ? -33.234 -12.970 -19.883 1.00 22.91 ? 53  ASP A CB  1 
ATOM   186  C CG  . ASP A 1 29  ? -32.456 -11.916 -20.642 1.00 30.82 ? 53  ASP A CG  1 
ATOM   187  O OD1 . ASP A 1 29  ? -31.216 -11.826 -20.453 1.00 25.45 ? 53  ASP A OD1 1 
ATOM   188  O OD2 . ASP A 1 29  ? -33.079 -11.178 -21.431 1.00 32.17 ? 53  ASP A OD2 1 
ATOM   189  N N   . ASN A 1 30  ? -30.139 -14.278 -18.643 1.00 16.42 ? 54  ASN A N   1 
ATOM   190  C CA  . ASN A 1 30  ? -28.985 -15.102 -18.991 1.00 19.58 ? 54  ASN A CA  1 
ATOM   191  C C   . ASN A 1 30  ? -28.583 -14.965 -20.453 1.00 20.18 ? 54  ASN A C   1 
ATOM   192  O O   . ASN A 1 30  ? -27.855 -15.817 -20.978 1.00 25.56 ? 54  ASN A O   1 
ATOM   193  C CB  . ASN A 1 30  ? -29.222 -16.579 -18.648 1.00 22.06 ? 54  ASN A CB  1 
ATOM   194  C CG  . ASN A 1 30  ? -29.244 -16.829 -17.153 1.00 30.76 ? 54  ASN A CG  1 
ATOM   195  O OD1 . ASN A 1 30  ? -28.611 -16.107 -16.376 1.00 29.55 ? 54  ASN A OD1 1 
ATOM   196  N ND2 . ASN A 1 30  ? -29.962 -17.870 -16.739 1.00 36.26 ? 54  ASN A ND2 1 
ATOM   197  N N   . THR A 1 31  ? -29.018 -13.910 -21.135 1.00 16.72 ? 55  THR A N   1 
ATOM   198  C CA  . THR A 1 31  ? -28.546 -13.729 -22.496 1.00 17.93 ? 55  THR A CA  1 
ATOM   199  C C   . THR A 1 31  ? -27.112 -13.212 -22.492 1.00 17.41 ? 55  THR A C   1 
ATOM   200  O O   . THR A 1 31  ? -26.594 -12.710 -21.485 1.00 14.48 ? 55  THR A O   1 
ATOM   201  C CB  . THR A 1 31  ? -29.443 -12.772 -23.275 1.00 17.85 ? 55  THR A CB  1 
ATOM   202  O OG1 . THR A 1 31  ? -29.485 -11.520 -22.588 1.00 19.40 ? 55  THR A OG1 1 
ATOM   203  C CG2 . THR A 1 31  ? -30.855 -13.349 -23.396 1.00 25.29 ? 55  THR A CG2 1 
ATOM   204  N N   . GLN A 1 32  ? -26.461 -13.365 -23.636 1.00 13.73 ? 56  GLN A N   1 
ATOM   205  C CA  . GLN A 1 32  ? -25.064 -12.984 -23.772 1.00 11.29 ? 56  GLN A CA  1 
ATOM   206  C C   . GLN A 1 32  ? -24.848 -12.250 -25.078 1.00 18.06 ? 56  GLN A C   1 
ATOM   207  O O   . GLN A 1 32  ? -25.562 -12.463 -26.064 1.00 17.95 ? 56  GLN A O   1 
ATOM   208  C CB  . GLN A 1 32  ? -24.120 -14.185 -23.731 1.00 15.35 ? 56  GLN A CB  1 
ATOM   209  C CG  . GLN A 1 32  ? -24.234 -15.041 -22.508 1.00 15.09 ? 56  GLN A CG  1 
ATOM   210  C CD  . GLN A 1 32  ? -23.593 -16.387 -22.726 1.00 19.31 ? 56  GLN A CD  1 
ATOM   211  O OE1 . GLN A 1 32  ? -24.275 -17.363 -23.003 1.00 17.06 ? 56  GLN A OE1 1 
ATOM   212  N NE2 . GLN A 1 32  ? -22.274 -16.446 -22.595 1.00 16.69 ? 56  GLN A NE2 1 
ATOM   213  N N   . VAL A 1 33  ? -23.835 -11.393 -25.077 1.00 11.78 ? 57  VAL A N   1 
ATOM   214  C CA  . VAL A 1 33  ? -23.294 -10.818 -26.292 1.00 12.29 ? 57  VAL A CA  1 
ATOM   215  C C   . VAL A 1 33  ? -21.809 -11.112 -26.268 1.00 12.58 ? 57  VAL A C   1 
ATOM   216  O O   . VAL A 1 33  ? -21.134 -10.812 -25.276 1.00 11.10 ? 57  VAL A O   1 
ATOM   217  C CB  . VAL A 1 33  ? -23.554 -9.304  -26.396 1.00 14.20 ? 57  VAL A CB  1 
ATOM   218  C CG1 . VAL A 1 33  ? -22.864 -8.741  -27.630 1.00 16.73 ? 57  VAL A CG1 1 
ATOM   219  C CG2 . VAL A 1 33  ? -25.047 -9.028  -26.443 1.00 18.23 ? 57  VAL A CG2 1 
ATOM   220  N N   . LEU A 1 34  ? -21.310 -11.715 -27.341 1.00 11.82 ? 59  LEU A N   1 
ATOM   221  C CA  . LEU A 1 34  ? -19.925 -12.144 -27.430 1.00 10.64 ? 59  LEU A CA  1 
ATOM   222  C C   . LEU A 1 34  ? -19.319 -11.615 -28.714 1.00 10.63 ? 59  LEU A C   1 
ATOM   223  O O   . LEU A 1 34  ? -19.951 -11.652 -29.776 1.00 12.62 ? 59  LEU A O   1 
ATOM   224  C CB  . LEU A 1 34  ? -19.836 -13.667 -27.393 1.00 10.73 ? 59  LEU A CB  1 
ATOM   225  C CG  . LEU A 1 34  ? -20.384 -14.246 -26.087 1.00 15.30 ? 59  LEU A CG  1 
ATOM   226  C CD1 . LEU A 1 34  ? -21.168 -15.495 -26.355 1.00 16.51 ? 59  LEU A CD1 1 
ATOM   227  C CD2 . LEU A 1 34  ? -19.217 -14.522 -25.155 1.00 14.44 ? 59  LEU A CD2 1 
ATOM   228  N N   . TYR A 1 35  ? -18.097 -11.112 -28.608 1.00 9.27  ? 60  TYR A N   1 
ATOM   229  C CA  . TYR A 1 35  ? -17.330 -10.678 -29.767 1.00 9.58  ? 60  TYR A CA  1 
ATOM   230  C C   . TYR A 1 35  ? -15.895 -11.108 -29.515 1.00 9.50  ? 60  TYR A C   1 
ATOM   231  O O   . TYR A 1 35  ? -15.275 -10.650 -28.550 1.00 9.19  ? 60  TYR A O   1 
ATOM   232  C CB  . TYR A 1 35  ? -17.427 -9.151  -29.992 1.00 11.30 ? 60  TYR A CB  1 
ATOM   233  C CG  . TYR A 1 35  ? -16.783 -8.709  -31.289 1.00 9.35  ? 60  TYR A CG  1 
ATOM   234  C CD1 . TYR A 1 35  ? -17.492 -8.738  -32.482 1.00 12.06 ? 60  TYR A CD1 1 
ATOM   235  C CD2 . TYR A 1 35  ? -15.456 -8.315  -31.322 1.00 8.76  ? 60  TYR A CD2 1 
ATOM   236  C CE1 . TYR A 1 35  ? -16.890 -8.370  -33.679 1.00 14.18 ? 60  TYR A CE1 1 
ATOM   237  C CE2 . TYR A 1 35  ? -14.842 -7.937  -32.518 1.00 10.47 ? 60  TYR A CE2 1 
ATOM   238  C CZ  . TYR A 1 35  ? -15.575 -7.969  -33.685 1.00 14.65 ? 60  TYR A CZ  1 
ATOM   239  O OH  . TYR A 1 35  ? -14.977 -7.624  -34.872 1.00 14.40 ? 60  TYR A OH  1 
ATOM   240  N N   . ARG A 1 36  ? -15.376 -12.014 -30.352 1.00 9.81  ? 61  ARG A N   1 
ATOM   241  C CA  . ARG A 1 36  ? -14.096 -12.666 -30.077 1.00 8.09  ? 61  ARG A CA  1 
ATOM   242  C C   . ARG A 1 36  ? -14.101 -13.241 -28.664 1.00 8.93  ? 61  ARG A C   1 
ATOM   243  O O   . ARG A 1 36  ? -13.103 -13.226 -27.945 1.00 8.89  ? 61  ARG A O   1 
ATOM   244  C CB  . ARG A 1 36  ? -12.932 -11.708 -30.303 1.00 9.17  ? 61  ARG A CB  1 
ATOM   245  C CG  . ARG A 1 36  ? -12.863 -11.166 -31.738 1.00 8.14  ? 61  ARG A CG  1 
ATOM   246  C CD  . ARG A 1 36  ? -11.510 -10.527 -32.026 1.00 9.33  ? 61  ARG A CD  1 
ATOM   247  N NE  . ARG A 1 36  ? -11.503 -9.815  -33.304 1.00 10.75 ? 61  ARG A NE  1 
ATOM   248  C CZ  . ARG A 1 36  ? -11.424 -10.405 -34.490 1.00 11.82 ? 61  ARG A CZ  1 
ATOM   249  N NH1 . ARG A 1 36  ? -11.292 -11.719 -34.604 1.00 12.57 ? 61  ARG A NH1 1 
ATOM   250  N NH2 . ARG A 1 36  ? -11.472 -9.656  -35.588 1.00 14.39 ? 61  ARG A NH2 1 
ATOM   251  N N   . GLY A 1 37  ? -15.260 -13.760 -28.267 1.00 9.60  ? 62  GLY A N   1 
ATOM   252  C CA  . GLY A 1 37  ? -15.443 -14.179 -26.889 1.00 8.90  ? 62  GLY A CA  1 
ATOM   253  C C   . GLY A 1 37  ? -14.602 -15.365 -26.479 1.00 9.15  ? 62  GLY A C   1 
ATOM   254  O O   . GLY A 1 37  ? -14.386 -15.565 -25.279 1.00 9.43  ? 62  GLY A O   1 
ATOM   255  N N   . ASP A 1 38  ? -14.108 -16.149 -27.441 1.00 7.39  ? 63  ASP A N   1 
ATOM   256  C CA  . ASP A 1 38  ? -13.287 -17.315 -27.141 1.00 9.63  ? 63  ASP A CA  1 
ATOM   257  C C   . ASP A 1 38  ? -11.833 -17.130 -27.541 1.00 7.82  ? 63  ASP A C   1 
ATOM   258  O O   . ASP A 1 38  ? -11.052 -18.086 -27.450 1.00 9.73  ? 63  ASP A O   1 
ATOM   259  C CB  . ASP A 1 38  ? -13.865 -18.562 -27.809 1.00 11.54 ? 63  ASP A CB  1 
ATOM   260  C CG  . ASP A 1 38  ? -15.236 -18.895 -27.288 1.00 12.14 ? 63  ASP A CG  1 
ATOM   261  O OD1 . ASP A 1 38  ? -15.375 -19.101 -26.062 1.00 12.92 ? 63  ASP A OD1 1 
ATOM   262  O OD2 . ASP A 1 38  ? -16.191 -18.924 -28.082 1.00 14.03 ? 63  ASP A OD2 1 
ATOM   263  N N   . GLU A 1 39  ? -11.431 -15.921 -27.947 1.00 8.71  ? 64  GLU A N   1 
ATOM   264  C CA  . GLU A 1 39  ? -10.014 -15.663 -28.171 1.00 7.44  ? 64  GLU A CA  1 
ATOM   265  C C   . GLU A 1 39  ? -9.318  -15.287 -26.868 1.00 8.90  ? 64  GLU A C   1 
ATOM   266  O O   . GLU A 1 39  ? -9.914  -14.673 -25.976 1.00 8.49  ? 64  GLU A O   1 
ATOM   267  C CB  . GLU A 1 39  ? -9.813  -14.546 -29.207 1.00 8.91  ? 64  GLU A CB  1 
ATOM   268  C CG  . GLU A 1 39  ? -10.296 -14.920 -30.592 1.00 9.19  ? 64  GLU A CG  1 
ATOM   269  C CD  . GLU A 1 39  ? -10.080 -13.826 -31.612 1.00 10.23 ? 64  GLU A CD  1 
ATOM   270  O OE1 . GLU A 1 39  ? -9.064  -13.097 -31.493 1.00 12.19 ? 64  GLU A OE1 1 
ATOM   271  O OE2 . GLU A 1 39  ? -10.917 -13.718 -32.548 1.00 10.23 ? 64  GLU A OE2 1 
ATOM   272  N N   . ARG A 1 40  ? -8.050  -15.669 -26.759 1.00 9.35  ? 65  ARG A N   1 
ATOM   273  C CA  . ARG A 1 40  ? -7.254  -15.300 -25.599 1.00 8.34  ? 65  ARG A CA  1 
ATOM   274  C C   . ARG A 1 40  ? -6.777  -13.866 -25.738 1.00 8.27  ? 65  ARG A C   1 
ATOM   275  O O   . ARG A 1 40  ? -6.447  -13.408 -26.836 1.00 10.18 ? 65  ARG A O   1 
ATOM   276  C CB  . ARG A 1 40  ? -6.057  -16.233 -25.426 1.00 9.36  ? 65  ARG A CB  1 
ATOM   277  C CG  . ARG A 1 40  ? -6.474  -17.549 -24.798 1.00 11.46 ? 65  ARG A CG  1 
ATOM   278  C CD  . ARG A 1 40  ? -5.322  -18.479 -24.547 1.00 12.50 ? 65  ARG A CD  1 
ATOM   279  N NE  . ARG A 1 40  ? -5.758  -19.699 -23.878 1.00 11.01 ? 65  ARG A NE  1 
ATOM   280  C CZ  . ARG A 1 40  ? -5.973  -19.799 -22.572 1.00 10.48 ? 65  ARG A CZ  1 
ATOM   281  N NH1 . ARG A 1 40  ? -5.711  -18.798 -21.746 1.00 9.76  ? 65  ARG A NH1 1 
ATOM   282  N NH2 . ARG A 1 40  ? -6.476  -20.931 -22.082 1.00 12.03 ? 65  ARG A NH2 1 
ATOM   283  N N   . PHE A 1 41  ? -6.754  -13.153 -24.615 1.00 7.42  ? 66  PHE A N   1 
ATOM   284  C CA  . PHE A 1 41  ? -6.238  -11.798 -24.496 1.00 9.53  ? 66  PHE A CA  1 
ATOM   285  C C   . PHE A 1 41  ? -5.339  -11.721 -23.270 1.00 8.30  ? 66  PHE A C   1 
ATOM   286  O O   . PHE A 1 41  ? -5.608  -12.390 -22.262 1.00 8.62  ? 66  PHE A O   1 
ATOM   287  C CB  . PHE A 1 41  ? -7.364  -10.765 -24.341 1.00 9.37  ? 66  PHE A CB  1 
ATOM   288  C CG  . PHE A 1 41  ? -8.205  -10.558 -25.579 1.00 8.58  ? 66  PHE A CG  1 
ATOM   289  C CD1 . PHE A 1 41  ? -9.201  -11.452 -25.916 1.00 9.17  ? 66  PHE A CD1 1 
ATOM   290  C CD2 . PHE A 1 41  ? -8.002  -9.439  -26.387 1.00 8.97  ? 66  PHE A CD2 1 
ATOM   291  C CE1 . PHE A 1 41  ? -9.998  -11.240 -27.044 1.00 8.38  ? 66  PHE A CE1 1 
ATOM   292  C CE2 . PHE A 1 41  ? -8.787  -9.210  -27.498 1.00 8.43  ? 66  PHE A CE2 1 
ATOM   293  C CZ  . PHE A 1 41  ? -9.786  -10.108 -27.840 1.00 9.12  ? 66  PHE A CZ  1 
ATOM   294  N N   . PRO A 1 42  ? -4.295  -10.895 -23.306 1.00 10.25 ? 67  PRO A N   1 
ATOM   295  C CA  . PRO A 1 42  ? -3.510  -10.648 -22.087 1.00 9.87  ? 67  PRO A CA  1 
ATOM   296  C C   . PRO A 1 42  ? -4.370  -9.928  -21.054 1.00 8.44  ? 67  PRO A C   1 
ATOM   297  O O   . PRO A 1 42  ? -4.950  -8.881  -21.341 1.00 12.48 ? 67  PRO A O   1 
ATOM   298  C CB  . PRO A 1 42  ? -2.351  -9.761  -22.562 1.00 10.92 ? 67  PRO A CB  1 
ATOM   299  C CG  . PRO A 1 42  ? -2.534  -9.563  -24.023 1.00 12.29 ? 67  PRO A CG  1 
ATOM   300  C CD  . PRO A 1 42  ? -3.827  -10.118 -24.468 1.00 11.41 ? 67  PRO A CD  1 
ATOM   301  N N   . MET A 1 43  ? -4.424  -10.485 -19.841 1.00 7.83  ? 68  MET A N   1 
ATOM   302  C CA  . MET A 1 43  ? -5.280  -9.930  -18.788 1.00 10.10 ? 68  MET A CA  1 
ATOM   303  C C   . MET A 1 43  ? -4.722  -8.665  -18.161 1.00 12.93 ? 68  MET A C   1 
ATOM   304  O O   . MET A 1 43  ? -5.504  -7.797  -17.737 1.00 10.93 ? 68  MET A O   1 
ATOM   305  C CB  . MET A 1 43  ? -5.499  -10.969 -17.690 1.00 11.95 ? 68  MET A CB  1 
ATOM   306  C CG  . MET A 1 43  ? -6.188  -12.233 -18.150 1.00 10.49 ? 68  MET A CG  1 
ATOM   307  S SD  . MET A 1 43  ? -6.457  -13.312 -16.749 1.00 11.32 ? 68  MET A SD  1 
ATOM   308  C CE  . MET A 1 43  ? -4.828  -14.084 -16.634 1.00 11.73 ? 68  MET A CE  1 
ATOM   309  N N   . CYS A 1 44  ? -3.396  -8.565  -18.061 1.00 10.88 ? 69  CYS A N   1 
ATOM   310  C CA  . CYS A 1 44  ? -2.744  -7.490  -17.322 1.00 11.62 ? 69  CYS A CA  1 
ATOM   311  C C   . CYS A 1 44  ? -3.377  -7.389  -15.938 1.00 9.33  ? 69  CYS A C   1 
ATOM   312  O O   . CYS A 1 44  ? -3.630  -8.424  -15.319 1.00 10.22 ? 69  CYS A O   1 
ATOM   313  C CB  . CYS A 1 44  ? -2.816  -6.184  -18.118 1.00 8.97  ? 69  CYS A CB  1 
ATOM   314  S SG  . CYS A 1 44  ? -1.970  -6.330  -19.730 1.00 13.19 ? 69  CYS A SG  1 
ATOM   315  N N   . SER A 1 45  ? -3.660  -6.186  -15.435 1.00 8.60  ? 70  SER A N   1 
ATOM   316  C CA  . SER A 1 45  ? -4.070  -6.098  -14.039 1.00 7.73  ? 70  SER A CA  1 
ATOM   317  C C   . SER A 1 45  ? -5.476  -6.612  -13.772 1.00 7.45  ? 70  SER A C   1 
ATOM   318  O O   . SER A 1 45  ? -5.866  -6.666  -12.601 1.00 7.82  ? 70  SER A O   1 
ATOM   319  C CB  . SER A 1 45  ? -3.959  -4.662  -13.545 1.00 7.80  ? 70  SER A CB  1 
ATOM   320  O OG  . SER A 1 45  ? -2.603  -4.386  -13.206 1.00 9.51  ? 70  SER A OG  1 
ATOM   321  N N   . THR A 1 46  ? -6.262  -6.988  -14.791 1.00 7.25  ? 71  THR A N   1 
ATOM   322  C CA  . THR A 1 46  ? -7.547  -7.610  -14.477 1.00 8.68  ? 71  THR A CA  1 
ATOM   323  C C   . THR A 1 46  ? -7.366  -8.948  -13.772 1.00 8.91  ? 71  THR A C   1 
ATOM   324  O O   . THR A 1 46  ? -8.290  -9.397  -13.081 1.00 10.02 ? 71  THR A O   1 
ATOM   325  C CB  . THR A 1 46  ? -8.434  -7.778  -15.726 1.00 8.68  ? 71  THR A CB  1 
ATOM   326  O OG1 . THR A 1 46  ? -7.873  -8.738  -16.635 1.00 9.08  ? 71  THR A OG1 1 
ATOM   327  C CG2 . THR A 1 46  ? -8.627  -6.436  -16.443 1.00 10.02 ? 71  THR A CG2 1 
ATOM   328  N N   . SER A 1 47  ? -6.174  -9.546  -13.865 1.00 9.27  ? 72  SER A N   1 
ATOM   329  C CA  . SER A 1 47  ? -5.903  -10.771 -13.128 1.00 9.93  ? 72  SER A CA  1 
ATOM   330  C C   . SER A 1 47  ? -5.858  -10.542 -11.621 1.00 9.82  ? 72  SER A C   1 
ATOM   331  O O   . SER A 1 47  ? -5.899  -11.515 -10.869 1.00 8.24  ? 72  SER A O   1 
ATOM   332  C CB  . SER A 1 47  ? -4.585  -11.390 -13.617 1.00 10.74 ? 72  SER A CB  1 
ATOM   333  O OG  . SER A 1 47  ? -3.487  -10.533 -13.359 1.00 11.47 ? 72  SER A OG  1 
ATOM   334  N N   . LYS A 1 48  ? -5.765  -9.290  -11.167 1.00 7.91  ? 73  LYS A N   1 
ATOM   335  C CA  . LYS A 1 48  ? -5.776  -9.006  -9.733  1.00 8.84  ? 73  LYS A CA  1 
ATOM   336  C C   . LYS A 1 48  ? -7.087  -9.430  -9.087  1.00 7.95  ? 73  LYS A C   1 
ATOM   337  O O   . LYS A 1 48  ? -7.108  -9.758  -7.899  1.00 9.59  ? 73  LYS A O   1 
ATOM   338  C CB  . LYS A 1 48  ? -5.505  -7.516  -9.500  1.00 7.51  ? 73  LYS A CB  1 
ATOM   339  C CG  . LYS A 1 48  ? -4.043  -7.112  -9.774  1.00 9.93  ? 73  LYS A CG  1 
ATOM   340  C CD  . LYS A 1 48  ? -3.886  -5.593  -9.726  1.00 9.43  ? 73  LYS A CD  1 
ATOM   341  C CE  . LYS A 1 48  ? -2.449  -5.140  -9.597  1.00 14.72 ? 73  LYS A CE  1 
ATOM   342  N NZ  . LYS A 1 48  ? -1.688  -5.460  -10.791 1.00 15.08 ? 73  LYS A NZ  1 
ATOM   343  N N   . VAL A 1 49  ? -8.183  -9.458  -9.847  1.00 8.20  ? 74  VAL A N   1 
ATOM   344  C CA  . VAL A 1 49  ? -9.446  -9.941  -9.288  1.00 7.29  ? 74  VAL A CA  1 
ATOM   345  C C   . VAL A 1 49  ? -9.327  -11.405 -8.891  1.00 7.86  ? 74  VAL A C   1 
ATOM   346  O O   . VAL A 1 49  ? -9.788  -11.813 -7.820  1.00 9.08  ? 74  VAL A O   1 
ATOM   347  C CB  . VAL A 1 49  ? -10.593 -9.722  -10.288 1.00 6.58  ? 74  VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 49  ? -11.891 -10.328 -9.748  1.00 11.31 ? 74  VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 49  ? -10.785 -8.233  -10.562 1.00 9.86  ? 74  VAL A CG2 1 
ATOM   350  N N   . MET A 1 50  ? -8.695  -12.214 -9.737  1.00 8.44  ? 75  MET A N   1 
ATOM   351  C CA  . MET A 1 50  ? -8.629  -13.637 -9.432  1.00 8.41  ? 75  MET A CA  1 
ATOM   352  C C   . MET A 1 50  ? -7.725  -13.856 -8.220  1.00 8.30  ? 75  MET A C   1 
ATOM   353  O O   . MET A 1 50  ? -8.001  -14.708 -7.367  1.00 8.69  ? 75  MET A O   1 
ATOM   354  C CB  . MET A 1 50  ? -8.079  -14.394 -10.639 1.00 7.90  ? 75  MET A CB  1 
ATOM   355  C CG  . MET A 1 50  ? -8.167  -15.931 -10.594 1.00 10.06 ? 75  MET A CG  1 
ATOM   356  S SD  . MET A 1 50  ? -9.879  -16.560 -10.629 1.00 11.94 ? 75  MET A SD  1 
ATOM   357  C CE  . MET A 1 50  ? -10.041 -16.651 -12.415 1.00 12.23 ? 75  MET A CE  1 
ATOM   358  N N   . ALA A 1 51  ? -6.617  -13.101 -8.128  1.00 7.71  ? 76  ALA A N   1 
ATOM   359  C CA  . ALA A 1 51  ? -5.709  -13.262 -6.993  1.00 7.50  ? 76  ALA A CA  1 
ATOM   360  C C   . ALA A 1 51  ? -6.352  -12.798 -5.693  1.00 8.04  ? 76  ALA A C   1 
ATOM   361  O O   . ALA A 1 51  ? -6.247  -13.477 -4.665  1.00 9.16  ? 76  ALA A O   1 
ATOM   362  C CB  . ALA A 1 51  ? -4.403  -12.507 -7.239  1.00 10.54 ? 76  ALA A CB  1 
ATOM   363  N N   . ALA A 1 52  ? -6.983  -11.624 -5.699  1.00 7.61  ? 77  ALA A N   1 
ATOM   364  C CA  . ALA A 1 52  ? -7.672  -11.177 -4.491  1.00 9.65  ? 77  ALA A CA  1 
ATOM   365  C C   . ALA A 1 52  ? -8.757  -12.159 -4.080  1.00 9.06  ? 77  ALA A C   1 
ATOM   366  O O   . ALA A 1 52  ? -8.903  -12.461 -2.889  1.00 8.29  ? 77  ALA A O   1 
ATOM   367  C CB  . ALA A 1 52  ? -8.273  -9.780  -4.679  1.00 8.87  ? 77  ALA A CB  1 
ATOM   368  N N   . ALA A 1 53  ? -9.526  -12.672 -5.048  1.00 7.97  ? 78  ALA A N   1 
ATOM   369  C CA  . ALA A 1 53  ? -10.586 -13.625 -4.724  1.00 8.38  ? 78  ALA A CA  1 
ATOM   370  C C   . ALA A 1 53  ? -10.009 -14.918 -4.154  1.00 8.93  ? 78  ALA A C   1 
ATOM   371  O O   . ALA A 1 53  ? -10.588 -15.508 -3.234  1.00 7.58  ? 78  ALA A O   1 
ATOM   372  C CB  . ALA A 1 53  ? -11.439 -13.906 -5.965  1.00 8.71  ? 78  ALA A CB  1 
ATOM   373  N N   . ALA A 1 54  ? -8.855  -15.360 -4.669  1.00 7.95  ? 79  ALA A N   1 
ATOM   374  C CA  . ALA A 1 54  ? -8.225  -16.569 -4.141  1.00 6.45  ? 79  ALA A CA  1 
ATOM   375  C C   . ALA A 1 54  ? -7.838  -16.396 -2.679  1.00 9.02  ? 79  ALA A C   1 
ATOM   376  O O   . ALA A 1 54  ? -7.980  -17.330 -1.879  1.00 7.95  ? 79  ALA A O   1 
ATOM   377  C CB  . ALA A 1 54  ? -6.991  -16.928 -4.974  1.00 8.31  ? 79  ALA A CB  1 
ATOM   378  N N   . VAL A 1 55  ? -7.324  -15.215 -2.309  1.00 9.22  ? 80  VAL A N   1 
ATOM   379  C CA  . VAL A 1 55  ? -6.973  -14.964 -0.914  1.00 9.32  ? 80  VAL A CA  1 
ATOM   380  C C   . VAL A 1 55  ? -8.232  -14.851 -0.056  1.00 8.83  ? 80  VAL A C   1 
ATOM   381  O O   . VAL A 1 55  ? -8.264  -15.339 1.085   1.00 8.84  ? 80  VAL A O   1 
ATOM   382  C CB  . VAL A 1 55  ? -6.088  -13.715 -0.807  1.00 7.55  ? 80  VAL A CB  1 
ATOM   383  C CG1 . VAL A 1 55  ? -5.889  -13.324 0.659   1.00 8.95  ? 80  VAL A CG1 1 
ATOM   384  C CG2 . VAL A 1 55  ? -4.728  -13.989 -1.487  1.00 6.70  ? 80  VAL A CG2 1 
ATOM   385  N N   . LEU A 1 56  ? -9.302  -14.242 -0.594  1.00 6.55  ? 81  LEU A N   1 
ATOM   386  C CA  . LEU A 1 56  ? -10.580 -14.235 0.107   1.00 8.20  ? 81  LEU A CA  1 
ATOM   387  C C   . LEU A 1 56  ? -11.061 -15.655 0.369   1.00 7.43  ? 81  LEU A C   1 
ATOM   388  O O   . LEU A 1 56  ? -11.516 -15.964 1.473   1.00 8.75  ? 81  LEU A O   1 
ATOM   389  C CB  . LEU A 1 56  ? -11.641 -13.463 -0.691  1.00 7.66  ? 81  LEU A CB  1 
ATOM   390  C CG  . LEU A 1 56  ? -11.592 -11.934 -0.599  1.00 6.20  ? 81  LEU A CG  1 
ATOM   391  C CD1 . LEU A 1 56  ? -12.540 -11.359 -1.628  1.00 9.12  ? 81  LEU A CD1 1 
ATOM   392  C CD2 . LEU A 1 56  ? -11.898 -11.414 0.815   1.00 9.09  ? 81  LEU A CD2 1 
ATOM   393  N N   . LYS A 1 57  ? -10.948 -16.543 -0.623  1.00 8.24  ? 82  LYS A N   1 
ATOM   394  C CA  . LYS A 1 57  ? -11.354 -17.927 -0.393  1.00 8.32  ? 82  LYS A CA  1 
ATOM   395  C C   . LYS A 1 57  ? -10.504 -18.575 0.693   1.00 9.16  ? 82  LYS A C   1 
ATOM   396  O O   . LYS A 1 57  ? -11.034 -19.285 1.556   1.00 9.73  ? 82  LYS A O   1 
ATOM   397  C CB  . LYS A 1 57  ? -11.285 -18.718 -1.702  1.00 7.71  ? 82  LYS A CB  1 
ATOM   398  C CG  . LYS A 1 57  ? -11.491 -20.246 -1.570  1.00 8.54  ? 82  LYS A CG  1 
ATOM   399  C CD  . LYS A 1 57  ? -12.854 -20.632 -0.991  1.00 12.99 ? 82  LYS A CD  1 
ATOM   400  C CE  . LYS A 1 57  ? -13.993 -20.283 -1.955  1.00 12.36 ? 82  LYS A CE  1 
ATOM   401  N NZ  . LYS A 1 57  ? -15.359 -20.662 -1.411  1.00 11.08 ? 82  LYS A NZ  1 
ATOM   402  N N   . GLN A 1 58  ? -9.188  -18.320 0.691   1.00 9.02  ? 83  GLN A N   1 
ATOM   403  C CA  . GLN A 1 58  ? -8.346  -18.857 1.758   1.00 9.76  ? 83  GLN A CA  1 
ATOM   404  C C   . GLN A 1 58  ? -8.826  -18.383 3.124   1.00 9.30  ? 83  GLN A C   1 
ATOM   405  O O   . GLN A 1 58  ? -8.829  -19.155 4.090   1.00 8.95  ? 83  GLN A O   1 
ATOM   406  C CB  . GLN A 1 58  ? -6.882  -18.467 1.532   1.00 8.96  ? 83  GLN A CB  1 
ATOM   407  C CG  . GLN A 1 58  ? -6.208  -19.219 0.380   1.00 8.10  ? 83  GLN A CG  1 
ATOM   408  C CD  . GLN A 1 58  ? -4.707  -19.060 0.395   1.00 12.79 ? 83  GLN A CD  1 
ATOM   409  O OE1 . GLN A 1 58  ? -4.191  -18.070 0.889   1.00 14.22 ? 83  GLN A OE1 1 
ATOM   410  N NE2 . GLN A 1 58  ? -3.999  -20.031 -0.178  1.00 14.94 ? 83  GLN A NE2 1 
ATOM   411  N N   . SER A 1 59  ? -9.242  -17.122 3.227   1.00 9.38  ? 84  SER A N   1 
ATOM   412  C CA  . SER A 1 59  ? -9.666  -16.565 4.507   1.00 8.43  ? 84  SER A CA  1 
ATOM   413  C C   . SER A 1 59  ? -10.985 -17.161 5.001   1.00 11.98 ? 84  SER A C   1 
ATOM   414  O O   . SER A 1 59  ? -11.338 -16.952 6.168   1.00 10.37 ? 84  SER A O   1 
ATOM   415  C CB  . SER A 1 59  ? -9.748  -15.029 4.407   1.00 8.75  ? 84  SER A CB  1 
ATOM   416  O OG  . SER A 1 59  ? -10.919 -14.597 3.735   1.00 9.50  ? 84  SER A OG  1 
ATOM   417  N N   . GLU A 1 60  ? -11.708 -17.914 4.157   1.00 8.53  ? 85  GLU A N   1 
ATOM   418  C CA  . GLU A 1 60  ? -12.888 -18.627 4.645   1.00 9.32  ? 85  GLU A CA  1 
ATOM   419  C C   . GLU A 1 60  ? -12.512 -19.710 5.632   1.00 10.26 ? 85  GLU A C   1 
ATOM   420  O O   . GLU A 1 60  ? -13.341 -20.082 6.462   1.00 9.49  ? 85  GLU A O   1 
ATOM   421  C CB  . GLU A 1 60  ? -13.684 -19.247 3.500   1.00 9.36  ? 85  GLU A CB  1 
ATOM   422  C CG  . GLU A 1 60  ? -14.188 -18.214 2.512   1.00 10.62 ? 85  GLU A CG  1 
ATOM   423  C CD  . GLU A 1 60  ? -15.023 -18.794 1.382   1.00 12.93 ? 85  GLU A CD  1 
ATOM   424  O OE1 . GLU A 1 60  ? -15.674 -19.865 1.555   1.00 13.50 ? 85  GLU A OE1 1 
ATOM   425  O OE2 . GLU A 1 60  ? -15.022 -18.157 0.304   1.00 12.10 ? 85  GLU A OE2 1 
ATOM   426  N N   . THR A 1 61  ? -11.287 -20.239 5.558   1.00 8.77  ? 86  THR A N   1 
ATOM   427  C CA  . THR A 1 61  ? -10.872 -21.271 6.504   1.00 9.17  ? 86  THR A CA  1 
ATOM   428  C C   . THR A 1 61  ? -9.687  -20.885 7.379   1.00 11.86 ? 86  THR A C   1 
ATOM   429  O O   . THR A 1 61  ? -9.572  -21.416 8.490   1.00 13.27 ? 86  THR A O   1 
ATOM   430  C CB  . THR A 1 61  ? -10.553 -22.587 5.777   1.00 9.92  ? 86  THR A CB  1 
ATOM   431  O OG1 . THR A 1 61  ? -9.567  -22.346 4.764   1.00 12.12 ? 86  THR A OG1 1 
ATOM   432  C CG2 . THR A 1 61  ? -11.820 -23.176 5.134   1.00 9.07  ? 86  THR A CG2 1 
ATOM   433  N N   . GLN A 1 62  ? -8.802  -19.993 6.921   1.00 10.21 ? 87  GLN A N   1 
ATOM   434  C CA  . GLN A 1 62  ? -7.826  -19.309 7.781   1.00 10.08 ? 87  GLN A CA  1 
ATOM   435  C C   . GLN A 1 62  ? -8.457  -17.983 8.179   1.00 11.36 ? 87  GLN A C   1 
ATOM   436  O O   . GLN A 1 62  ? -8.284  -16.968 7.518   1.00 10.71 ? 87  GLN A O   1 
ATOM   437  C CB  . GLN A 1 62  ? -6.497  -19.116 7.058   1.00 8.61  ? 87  GLN A CB  1 
ATOM   438  C CG  . GLN A 1 62  ? -5.964  -20.382 6.402   1.00 12.42 ? 87  GLN A CG  1 
ATOM   439  C CD  . GLN A 1 62  ? -4.743  -20.121 5.546   1.00 11.06 ? 87  GLN A CD  1 
ATOM   440  O OE1 . GLN A 1 62  ? -4.804  -20.257 4.331   1.00 13.57 ? 87  GLN A OE1 1 
ATOM   441  N NE2 . GLN A 1 62  ? -3.618  -19.800 6.178   1.00 13.59 ? 87  GLN A NE2 1 
ATOM   442  N N   A LYS A 1 63  ? -9.180  -17.991 9.299   0.54 13.28 ? 88  LYS A N   1 
ATOM   443  N N   B LYS A 1 63  ? -9.188  -17.995 9.295   0.46 13.28 ? 88  LYS A N   1 
ATOM   444  C CA  A LYS A 1 63  ? -10.155 -16.940 9.571   0.54 12.28 ? 88  LYS A CA  1 
ATOM   445  C CA  B LYS A 1 63  ? -10.159 -16.942 9.575   0.46 12.29 ? 88  LYS A CA  1 
ATOM   446  C C   A LYS A 1 63  ? -9.532  -15.579 9.848   0.54 9.79  ? 88  LYS A C   1 
ATOM   447  C C   B LYS A 1 63  ? -9.533  -15.580 9.849   0.46 9.82  ? 88  LYS A C   1 
ATOM   448  O O   A LYS A 1 63  ? -10.211 -14.563 9.670   0.54 14.89 ? 88  LYS A O   1 
ATOM   449  O O   B LYS A 1 63  ? -10.210 -14.563 9.668   0.46 14.89 ? 88  LYS A O   1 
ATOM   450  C CB  A LYS A 1 63  ? -11.047 -17.350 10.742  0.54 16.00 ? 88  LYS A CB  1 
ATOM   451  C CB  B LYS A 1 63  ? -11.044 -17.353 10.752  0.46 16.01 ? 88  LYS A CB  1 
ATOM   452  C CG  A LYS A 1 63  ? -11.969 -18.519 10.429  0.54 13.59 ? 88  LYS A CG  1 
ATOM   453  C CG  B LYS A 1 63  ? -11.914 -18.571 10.468  0.46 13.69 ? 88  LYS A CG  1 
ATOM   454  C CD  A LYS A 1 63  ? -12.573 -18.413 9.042   0.54 17.57 ? 88  LYS A CD  1 
ATOM   455  C CD  B LYS A 1 63  ? -13.080 -18.654 11.447  0.46 18.55 ? 88  LYS A CD  1 
ATOM   456  C CE  A LYS A 1 63  ? -13.983 -17.822 9.080   0.54 26.84 ? 88  LYS A CE  1 
ATOM   457  C CE  B LYS A 1 63  ? -13.830 -19.968 11.313  0.46 21.52 ? 88  LYS A CE  1 
ATOM   458  N NZ  A LYS A 1 63  ? -14.828 -18.188 7.888   0.54 7.92  ? 88  LYS A NZ  1 
ATOM   459  N NZ  B LYS A 1 63  ? -14.719 -20.248 12.487  0.46 21.64 ? 88  LYS A NZ  1 
ATOM   460  N N   . GLN A 1 64  ? -8.272  -15.520 10.276  1.00 11.71 ? 89  GLN A N   1 
ATOM   461  C CA  . GLN A 1 64  ? -7.610  -14.241 10.502  1.00 12.13 ? 89  GLN A CA  1 
ATOM   462  C C   . GLN A 1 64  ? -6.602  -13.905 9.414   1.00 14.85 ? 89  GLN A C   1 
ATOM   463  O O   . GLN A 1 64  ? -5.782  -12.998 9.599   1.00 12.83 ? 89  GLN A O   1 
ATOM   464  C CB  . GLN A 1 64  ? -6.929  -14.210 11.872  1.00 14.76 ? 89  GLN A CB  1 
ATOM   465  C CG  . GLN A 1 64  ? -7.698  -14.955 12.929  1.00 22.11 ? 89  GLN A CG  1 
ATOM   466  C CD  . GLN A 1 64  ? -9.055  -14.330 13.159  1.00 18.73 ? 89  GLN A CD  1 
ATOM   467  O OE1 . GLN A 1 64  ? -9.227  -13.118 13.013  1.00 21.90 ? 89  GLN A OE1 1 
ATOM   468  N NE2 . GLN A 1 64  ? -10.044 -15.162 13.437  1.00 18.39 ? 89  GLN A NE2 1 
ATOM   469  N N   . LEU A 1 65  ? -6.660  -14.602 8.276   1.00 11.78 ? 90  LEU A N   1 
ATOM   470  C CA  . LEU A 1 65  ? -5.641  -14.415 7.249   1.00 9.53  ? 90  LEU A CA  1 
ATOM   471  C C   . LEU A 1 65  ? -5.577  -12.974 6.757   1.00 11.37 ? 90  LEU A C   1 
ATOM   472  O O   . LEU A 1 65  ? -4.485  -12.465 6.472   1.00 11.61 ? 90  LEU A O   1 
ATOM   473  C CB  . LEU A 1 65  ? -5.903  -15.367 6.083   1.00 10.35 ? 90  LEU A CB  1 
ATOM   474  C CG  . LEU A 1 65  ? -4.905  -15.334 4.934   1.00 10.18 ? 90  LEU A CG  1 
ATOM   475  C CD1 . LEU A 1 65  ? -3.512  -15.749 5.411   1.00 11.43 ? 90  LEU A CD1 1 
ATOM   476  C CD2 . LEU A 1 65  ? -5.394  -16.237 3.802   1.00 9.81  ? 90  LEU A CD2 1 
ATOM   477  N N   . LEU A 1 66  ? -6.728  -12.305 6.618   1.00 10.68 ? 91  LEU A N   1 
ATOM   478  C CA  . LEU A 1 66  ? -6.692  -10.974 6.020   1.00 12.31 ? 91  LEU A CA  1 
ATOM   479  C C   . LEU A 1 66  ? -6.002  -9.954  6.916   1.00 13.19 ? 91  LEU A C   1 
ATOM   480  O O   . LEU A 1 66  ? -5.592  -8.897  6.419   1.00 12.49 ? 91  LEU A O   1 
ATOM   481  C CB  . LEU A 1 66  ? -8.102  -10.511 5.670   1.00 10.79 ? 91  LEU A CB  1 
ATOM   482  C CG  . LEU A 1 66  ? -8.844  -11.344 4.618   1.00 11.35 ? 91  LEU A CG  1 
ATOM   483  C CD1 . LEU A 1 66  ? -10.168 -10.698 4.277   1.00 11.74 ? 91  LEU A CD1 1 
ATOM   484  C CD2 . LEU A 1 66  ? -8.001  -11.523 3.375   1.00 13.84 ? 91  LEU A CD2 1 
ATOM   485  N N   . ASN A 1 67  ? -5.832  -10.248 8.207   1.00 14.18 ? 92  ASN A N   1 
ATOM   486  C CA  . ASN A 1 67  ? -5.114  -9.350  9.107   1.00 12.32 ? 92  ASN A CA  1 
ATOM   487  C C   . ASN A 1 67  ? -3.632  -9.673  9.229   1.00 16.51 ? 92  ASN A C   1 
ATOM   488  O O   . ASN A 1 67  ? -2.937  -9.009  10.006  1.00 18.88 ? 92  ASN A O   1 
ATOM   489  C CB  . ASN A 1 67  ? -5.737  -9.380  10.504  1.00 18.59 ? 92  ASN A CB  1 
ATOM   490  C CG  . ASN A 1 67  ? -7.235  -9.315  10.465  1.00 26.26 ? 92  ASN A CG  1 
ATOM   491  O OD1 . ASN A 1 67  ? -7.815  -8.593  9.652   1.00 36.22 ? 92  ASN A OD1 1 
ATOM   492  N ND2 . ASN A 1 67  ? -7.883  -10.079 11.343  1.00 31.58 ? 92  ASN A ND2 1 
ATOM   493  N N   A GLN A 1 68  ? -3.134  -10.659 8.492   0.52 12.87 ? 93  GLN A N   1 
ATOM   494  N N   B GLN A 1 68  ? -3.144  -10.664 8.492   0.48 12.90 ? 93  GLN A N   1 
ATOM   495  C CA  A GLN A 1 68  ? -1.754  -11.096 8.659   0.52 16.28 ? 93  GLN A CA  1 
ATOM   496  C CA  B GLN A 1 68  ? -1.757  -11.095 8.611   0.48 16.29 ? 93  GLN A CA  1 
ATOM   497  C C   A GLN A 1 68  ? -0.798  -10.074 8.054   0.52 15.57 ? 93  GLN A C   1 
ATOM   498  C C   B GLN A 1 68  ? -0.820  -10.029 8.054   0.48 15.53 ? 93  GLN A C   1 
ATOM   499  O O   A GLN A 1 68  ? -0.943  -9.714  6.882   0.52 15.20 ? 93  GLN A O   1 
ATOM   500  O O   B GLN A 1 68  ? -0.998  -9.595  6.912   0.48 15.12 ? 93  GLN A O   1 
ATOM   501  C CB  A GLN A 1 68  ? -1.553  -12.463 8.008   0.52 16.45 ? 93  GLN A CB  1 
ATOM   502  C CB  B GLN A 1 68  ? -1.563  -12.408 7.857   0.48 16.07 ? 93  GLN A CB  1 
ATOM   503  C CG  A GLN A 1 68  ? -0.105  -12.898 7.877   0.52 20.17 ? 93  GLN A CG  1 
ATOM   504  C CG  B GLN A 1 68  ? -0.125  -12.753 7.544   0.48 20.96 ? 93  GLN A CG  1 
ATOM   505  C CD  A GLN A 1 68  ? 0.050   -14.407 7.858   0.52 27.30 ? 93  GLN A CD  1 
ATOM   506  C CD  B GLN A 1 68  ? 0.576   -13.387 8.721   0.48 19.60 ? 93  GLN A CD  1 
ATOM   507  O OE1 A GLN A 1 68  ? -0.906  -15.137 7.601   0.52 25.94 ? 93  GLN A OE1 1 
ATOM   508  O OE1 B GLN A 1 68  ? 0.110   -14.388 9.263   0.48 21.35 ? 93  GLN A OE1 1 
ATOM   509  N NE2 A GLN A 1 68  ? 1.262   -14.881 8.125   0.52 34.51 ? 93  GLN A NE2 1 
ATOM   510  N NE2 B GLN A 1 68  ? 1.702   -12.812 9.123   0.48 23.48 ? 93  GLN A NE2 1 
ATOM   511  N N   . PRO A 1 69  ? 0.179   -9.586  8.813   1.00 16.22 ? 94  PRO A N   1 
ATOM   512  C CA  . PRO A 1 69  ? 1.137   -8.614  8.261   1.00 15.85 ? 94  PRO A CA  1 
ATOM   513  C C   . PRO A 1 69  ? 2.093   -9.255  7.269   1.00 13.24 ? 94  PRO A C   1 
ATOM   514  O O   . PRO A 1 69  ? 2.520   -10.401 7.427   1.00 16.16 ? 94  PRO A O   1 
ATOM   515  C CB  . PRO A 1 69  ? 1.886   -8.111  9.501   1.00 15.92 ? 94  PRO A CB  1 
ATOM   516  C CG  . PRO A 1 69  ? 0.943   -8.434  10.668  1.00 22.51 ? 94  PRO A CG  1 
ATOM   517  C CD  . PRO A 1 69  ? 0.343   -9.758  10.266  1.00 14.92 ? 94  PRO A CD  1 
ATOM   518  N N   . VAL A 1 70  ? 2.426   -8.493  6.235   1.00 10.62 ? 95  VAL A N   1 
ATOM   519  C CA  . VAL A 1 70  ? 3.358   -8.907  5.196   1.00 14.95 ? 95  VAL A CA  1 
ATOM   520  C C   . VAL A 1 70  ? 4.430   -7.829  5.074   1.00 11.98 ? 95  VAL A C   1 
ATOM   521  O O   . VAL A 1 70  ? 4.107   -6.645  4.944   1.00 12.70 ? 95  VAL A O   1 
ATOM   522  C CB  . VAL A 1 70  ? 2.645   -9.122  3.846   1.00 15.90 ? 95  VAL A CB  1 
ATOM   523  C CG1 . VAL A 1 70  ? 3.628   -9.536  2.782   1.00 17.12 ? 95  VAL A CG1 1 
ATOM   524  C CG2 . VAL A 1 70  ? 1.506   -10.150 3.985   1.00 13.71 ? 95  VAL A CG2 1 
ATOM   525  N N   . GLU A 1 71  ? 5.698   -8.238  5.129   1.00 14.19 ? 96  GLU A N   1 
ATOM   526  C CA  . GLU A 1 71  ? 6.804   -7.289  5.031   1.00 13.06 ? 96  GLU A CA  1 
ATOM   527  C C   . GLU A 1 71  ? 6.892   -6.701  3.627   1.00 11.49 ? 96  GLU A C   1 
ATOM   528  O O   . GLU A 1 71  ? 6.877   -7.434  2.636   1.00 13.86 ? 96  GLU A O   1 
ATOM   529  C CB  . GLU A 1 71  ? 8.127   -7.975  5.387   1.00 15.46 ? 96  GLU A CB  1 
ATOM   530  C CG  . GLU A 1 71  ? 8.302   -8.311  6.873   1.00 18.02 ? 96  GLU A CG  1 
ATOM   531  C CD  . GLU A 1 71  ? 9.712   -8.787  7.187   1.00 32.42 ? 96  GLU A CD  1 
ATOM   532  O OE1 . GLU A 1 71  ? 10.525  -8.903  6.243   1.00 42.58 ? 96  GLU A OE1 1 
ATOM   533  O OE2 . GLU A 1 71  ? 10.017  -9.029  8.372   1.00 29.65 ? 96  GLU A OE2 1 
ATOM   534  N N   . ILE A 1 72  ? 7.011   -5.378  3.541   1.00 11.10 ? 97  ILE A N   1 
ATOM   535  C CA  . ILE A 1 72  ? 7.263   -4.675  2.283   1.00 12.65 ? 97  ILE A CA  1 
ATOM   536  C C   . ILE A 1 72  ? 8.698   -4.170  2.326   1.00 12.58 ? 97  ILE A C   1 
ATOM   537  O O   . ILE A 1 72  ? 9.012   -3.256  3.101   1.00 13.40 ? 97  ILE A O   1 
ATOM   538  C CB  . ILE A 1 72  ? 6.288   -3.509  2.064   1.00 11.06 ? 97  ILE A CB  1 
ATOM   539  C CG1 . ILE A 1 72  ? 4.838   -3.918  2.348   1.00 14.03 ? 97  ILE A CG1 1 
ATOM   540  C CG2 . ILE A 1 72  ? 6.433   -2.958  0.651   1.00 15.14 ? 97  ILE A CG2 1 
ATOM   541  C CD1 . ILE A 1 72  ? 4.330   -5.011  1.435   1.00 18.23 ? 97  ILE A CD1 1 
ATOM   542  N N   . LYS A 1 73  ? 9.571   -4.737  1.489   1.00 11.33 ? 98  LYS A N   1 
ATOM   543  C CA  . LYS A 1 73  ? 10.972  -4.327  1.475   1.00 11.81 ? 98  LYS A CA  1 
ATOM   544  C C   . LYS A 1 73  ? 11.283  -3.464  0.262   1.00 13.86 ? 98  LYS A C   1 
ATOM   545  O O   . LYS A 1 73  ? 10.609  -3.547  -0.768  1.00 13.09 ? 98  LYS A O   1 
ATOM   546  C CB  . LYS A 1 73  ? 11.892  -5.553  1.479   1.00 14.54 ? 98  LYS A CB  1 
ATOM   547  C CG  . LYS A 1 73  ? 11.679  -6.476  2.661   1.00 18.74 ? 98  LYS A CG  1 
ATOM   548  C CD  . LYS A 1 73  ? 12.878  -7.392  2.857   1.00 33.55 ? 98  LYS A CD  1 
ATOM   549  C CE  . LYS A 1 73  ? 12.512  -8.604  3.700   1.00 42.93 ? 98  LYS A CE  1 
ATOM   550  N NZ  . LYS A 1 73  ? 13.698  -9.216  4.361   1.00 37.77 ? 98  LYS A NZ  1 
ATOM   551  N N   . PRO A 1 74  ? 12.312  -2.610  0.346   1.00 15.57 ? 99  PRO A N   1 
ATOM   552  C CA  . PRO A 1 74  ? 12.671  -1.798  -0.824  1.00 14.77 ? 99  PRO A CA  1 
ATOM   553  C C   . PRO A 1 74  ? 12.837  -2.619  -2.087  1.00 13.37 ? 99  PRO A C   1 
ATOM   554  O O   . PRO A 1 74  ? 12.390  -2.194  -3.160  1.00 17.52 ? 99  PRO A O   1 
ATOM   555  C CB  . PRO A 1 74  ? 13.997  -1.156  -0.395  1.00 19.81 ? 99  PRO A CB  1 
ATOM   556  C CG  . PRO A 1 74  ? 13.874  -1.021  1.079   1.00 15.80 ? 99  PRO A CG  1 
ATOM   557  C CD  . PRO A 1 74  ? 13.076  -2.226  1.548   1.00 15.31 ? 99  PRO A CD  1 
ATOM   558  N N   . ALA A 1 75  ? 13.442  -3.806  -1.985  1.00 14.73 ? 100 ALA A N   1 
ATOM   559  C CA  . ALA A 1 75  ? 13.687  -4.618  -3.169  1.00 22.04 ? 100 ALA A CA  1 
ATOM   560  C C   . ALA A 1 75  ? 12.416  -5.230  -3.740  1.00 17.30 ? 100 ALA A C   1 
ATOM   561  O O   . ALA A 1 75  ? 12.456  -5.759  -4.857  1.00 19.22 ? 100 ALA A O   1 
ATOM   562  C CB  . ALA A 1 75  ? 14.695  -5.724  -2.852  1.00 22.40 ? 100 ALA A CB  1 
ATOM   563  N N   . ASP A 1 76  ? 11.296  -5.174  -3.009  1.00 16.53 ? 101 ASP A N   1 
ATOM   564  C CA  . ASP A 1 76  ? 10.029  -5.704  -3.500  1.00 15.14 ? 101 ASP A CA  1 
ATOM   565  C C   . ASP A 1 76  ? 9.321   -4.758  -4.451  1.00 17.68 ? 101 ASP A C   1 
ATOM   566  O O   . ASP A 1 76  ? 8.428   -5.197  -5.182  1.00 16.31 ? 101 ASP A O   1 
ATOM   567  C CB  . ASP A 1 76  ? 9.069   -5.997  -2.341  1.00 16.30 ? 101 ASP A CB  1 
ATOM   568  C CG  . ASP A 1 76  ? 9.628   -6.995  -1.360  1.00 21.84 ? 101 ASP A CG  1 
ATOM   569  O OD1 . ASP A 1 76  ? 10.579  -7.714  -1.732  1.00 22.96 ? 101 ASP A OD1 1 
ATOM   570  O OD2 . ASP A 1 76  ? 9.110   -7.068  -0.223  1.00 19.87 ? 101 ASP A OD2 1 
ATOM   571  N N   . LEU A 1 77  ? 9.662   -3.474  -4.432  1.00 14.58 ? 102 LEU A N   1 
ATOM   572  C CA  . LEU A 1 77  ? 8.976   -2.508  -5.274  1.00 14.88 ? 102 LEU A CA  1 
ATOM   573  C C   . LEU A 1 77  ? 9.263   -2.780  -6.745  1.00 16.43 ? 102 LEU A C   1 
ATOM   574  O O   . LEU A 1 77  ? 10.419  -2.975  -7.141  1.00 19.04 ? 102 LEU A O   1 
ATOM   575  C CB  . LEU A 1 77  ? 9.405   -1.087  -4.903  1.00 13.78 ? 102 LEU A CB  1 
ATOM   576  C CG  . LEU A 1 77  ? 9.032   -0.601  -3.504  1.00 17.78 ? 102 LEU A CG  1 
ATOM   577  C CD1 . LEU A 1 77  ? 9.375   0.889   -3.368  1.00 20.32 ? 102 LEU A CD1 1 
ATOM   578  C CD2 . LEU A 1 77  ? 7.547   -0.853  -3.234  1.00 17.10 ? 102 LEU A CD2 1 
ATOM   579  N N   . VAL A 1 78  ? 8.210   -2.794  -7.555  1.00 15.22 ? 103 VAL A N   1 
ATOM   580  C CA  . VAL A 1 78  ? 8.364   -2.989  -8.991  1.00 15.28 ? 103 VAL A CA  1 
ATOM   581  C C   . VAL A 1 78  ? 8.050   -1.669  -9.690  1.00 13.63 ? 103 VAL A C   1 
ATOM   582  O O   . VAL A 1 78  ? 8.533   -0.615  -9.270  1.00 17.00 ? 103 VAL A O   1 
ATOM   583  C CB  . VAL A 1 78  ? 7.509   -4.168  -9.505  1.00 11.75 ? 103 VAL A CB  1 
ATOM   584  C CG1 . VAL A 1 78  ? 8.154   -5.494  -9.099  1.00 17.95 ? 103 VAL A CG1 1 
ATOM   585  C CG2 . VAL A 1 78  ? 6.082   -4.122  -8.962  1.00 12.07 ? 103 VAL A CG2 1 
ATOM   586  N N   . ASN A 1 79  ? 7.242   -1.697  -10.745 1.00 14.27 ? 104 ASN A N   1 
ATOM   587  C CA  . ASN A 1 79  ? 7.140   -0.541  -11.628 1.00 16.57 ? 104 ASN A CA  1 
ATOM   588  C C   . ASN A 1 79  ? 5.976   0.391   -11.317 1.00 18.97 ? 104 ASN A C   1 
ATOM   589  O O   . ASN A 1 79  ? 5.923   1.490   -11.877 1.00 25.70 ? 104 ASN A O   1 
ATOM   590  C CB  . ASN A 1 79  ? 7.028   -0.998  -13.083 1.00 15.71 ? 104 ASN A CB  1 
ATOM   591  C CG  . ASN A 1 79  ? 5.769   -1.799  -13.345 1.00 17.43 ? 104 ASN A CG  1 
ATOM   592  O OD1 . ASN A 1 79  ? 5.329   -2.594  -12.504 1.00 15.40 ? 104 ASN A OD1 1 
ATOM   593  N ND2 . ASN A 1 79  ? 5.173   -1.588  -14.510 1.00 24.04 ? 104 ASN A ND2 1 
ATOM   594  N N   . TYR A 1 80  ? 5.035   -0.006  -10.463 1.00 14.43 ? 105 TYR A N   1 
ATOM   595  C CA  . TYR A 1 80  ? 3.876   0.840   -10.186 1.00 13.55 ? 105 TYR A CA  1 
ATOM   596  C C   . TYR A 1 80  ? 3.358   0.431   -8.807  1.00 14.98 ? 105 TYR A C   1 
ATOM   597  O O   . TYR A 1 80  ? 2.650   -0.574  -8.680  1.00 16.21 ? 105 TYR A O   1 
ATOM   598  C CB  . TYR A 1 80  ? 2.799   0.698   -11.249 1.00 16.41 ? 105 TYR A CB  1 
ATOM   599  C CG  . TYR A 1 80  ? 1.670   1.658   -11.004 1.00 18.08 ? 105 TYR A CG  1 
ATOM   600  C CD1 . TYR A 1 80  ? 1.901   3.024   -11.037 1.00 21.70 ? 105 TYR A CD1 1 
ATOM   601  C CD2 . TYR A 1 80  ? 0.392   1.209   -10.680 1.00 16.32 ? 105 TYR A CD2 1 
ATOM   602  C CE1 . TYR A 1 80  ? 0.896   3.929   -10.794 1.00 26.54 ? 105 TYR A CE1 1 
ATOM   603  C CE2 . TYR A 1 80  ? -0.638  2.117   -10.432 1.00 19.38 ? 105 TYR A CE2 1 
ATOM   604  C CZ  . TYR A 1 80  ? -0.370  3.479   -10.492 1.00 29.02 ? 105 TYR A CZ  1 
ATOM   605  O OH  . TYR A 1 80  ? -1.353  4.413   -10.250 1.00 24.80 ? 105 TYR A OH  1 
ATOM   606  N N   A ASN A 1 81  ? 3.740   1.188   -7.785  0.19 13.59 ? 106 ASN A N   1 
ATOM   607  N N   B ASN A 1 81  ? 3.688   1.231   -7.796  0.81 13.49 ? 106 ASN A N   1 
ATOM   608  C CA  A ASN A 1 81  ? 3.443   0.835   -6.397  0.19 11.75 ? 106 ASN A CA  1 
ATOM   609  C CA  B ASN A 1 81  ? 3.464   0.847   -6.401  0.81 11.57 ? 106 ASN A CA  1 
ATOM   610  C C   A ASN A 1 81  ? 2.920   2.050   -5.642  0.19 13.60 ? 106 ASN A C   1 
ATOM   611  C C   B ASN A 1 81  ? 2.895   2.017   -5.605  0.81 13.55 ? 106 ASN A C   1 
ATOM   612  O O   A ASN A 1 81  ? 3.547   2.522   -4.691  0.19 14.86 ? 106 ASN A O   1 
ATOM   613  O O   B ASN A 1 81  ? 3.447   2.404   -4.573  0.81 14.43 ? 106 ASN A O   1 
ATOM   614  C CB  A ASN A 1 81  ? 4.688   0.265   -5.720  0.19 16.75 ? 106 ASN A CB  1 
ATOM   615  C CB  B ASN A 1 81  ? 4.777   0.364   -5.781  0.81 17.01 ? 106 ASN A CB  1 
ATOM   616  C CG  A ASN A 1 81  ? 5.970   0.838   -6.292  0.19 16.94 ? 106 ASN A CG  1 
ATOM   617  C CG  B ASN A 1 81  ? 5.773   -0.125  -6.821  0.81 13.80 ? 106 ASN A CG  1 
ATOM   618  O OD1 A ASN A 1 81  ? 6.390   1.933   -5.924  0.19 18.83 ? 106 ASN A OD1 1 
ATOM   619  O OD1 B ASN A 1 81  ? 5.631   -1.214  -7.368  0.81 14.18 ? 106 ASN A OD1 1 
ATOM   620  N ND2 A ASN A 1 81  ? 6.596   0.099   -7.201  0.19 14.80 ? 106 ASN A ND2 1 
ATOM   621  N ND2 B ASN A 1 81  ? 6.777   0.689   -7.108  0.81 15.74 ? 106 ASN A ND2 1 
ATOM   622  N N   . PRO A 1 82  ? 1.752   2.570   -6.029  1.00 13.39 ? 107 PRO A N   1 
ATOM   623  C CA  . PRO A 1 82  ? 1.235   3.787   -5.364  1.00 12.67 ? 107 PRO A CA  1 
ATOM   624  C C   . PRO A 1 82  ? 0.962   3.631   -3.881  1.00 13.05 ? 107 PRO A C   1 
ATOM   625  O O   . PRO A 1 82  ? 1.069   4.616   -3.134  1.00 16.05 ? 107 PRO A O   1 
ATOM   626  C CB  . PRO A 1 82  ? -0.057  4.080   -6.140  1.00 16.50 ? 107 PRO A CB  1 
ATOM   627  C CG  . PRO A 1 82  ? -0.467  2.763   -6.701  1.00 15.59 ? 107 PRO A CG  1 
ATOM   628  C CD  . PRO A 1 82  ? 0.831   2.092   -7.074  1.00 14.30 ? 107 PRO A CD  1 
ATOM   629  N N   . ILE A 1 83  ? 0.619   2.438   -3.415  1.00 11.02 ? 108 ILE A N   1 
ATOM   630  C CA  . ILE A 1 83  ? 0.317   2.223   -2.011  1.00 12.06 ? 108 ILE A CA  1 
ATOM   631  C C   . ILE A 1 83  ? 1.488   1.585   -1.291  1.00 13.34 ? 108 ILE A C   1 
ATOM   632  O O   . ILE A 1 83  ? 1.865   2.011   -0.196  1.00 12.80 ? 108 ILE A O   1 
ATOM   633  C CB  . ILE A 1 83  ? -0.967  1.377   -1.843  1.00 9.58  ? 108 ILE A CB  1 
ATOM   634  C CG1 . ILE A 1 83  ? -2.124  1.953   -2.662  1.00 13.58 ? 108 ILE A CG1 1 
ATOM   635  C CG2 . ILE A 1 83  ? -1.354  1.277   -0.377  1.00 13.92 ? 108 ILE A CG2 1 
ATOM   636  C CD1 . ILE A 1 83  ? -2.455  3.399   -2.330  1.00 15.50 ? 108 ILE A CD1 1 
ATOM   637  N N   . ALA A 1 84  ? 2.086   0.560   -1.901  1.00 10.86 ? 109 ALA A N   1 
ATOM   638  C CA  . ALA A 1 84  ? 3.172   -0.149  -1.234  1.00 10.17 ? 109 ALA A CA  1 
ATOM   639  C C   . ALA A 1 84  ? 4.367   0.751   -0.948  1.00 14.06 ? 109 ALA A C   1 
ATOM   640  O O   . ALA A 1 84  ? 5.080   0.530   0.038   1.00 13.54 ? 109 ALA A O   1 
ATOM   641  C CB  . ALA A 1 84  ? 3.596   -1.355  -2.075  1.00 11.30 ? 109 ALA A CB  1 
ATOM   642  N N   A GLU A 1 85  ? 4.616   1.758   -1.789  0.54 13.03 ? 110 GLU A N   1 
ATOM   643  N N   B GLU A 1 85  ? 4.596   1.768   -1.781  0.46 13.04 ? 110 GLU A N   1 
ATOM   644  C CA  A GLU A 1 85  ? 5.757   2.637   -1.544  0.54 14.86 ? 110 GLU A CA  1 
ATOM   645  C CA  B GLU A 1 85  ? 5.727   2.661   -1.551  0.46 14.88 ? 110 GLU A CA  1 
ATOM   646  C C   A GLU A 1 85  ? 5.599   3.430   -0.252  0.54 14.22 ? 110 GLU A C   1 
ATOM   647  C C   B GLU A 1 85  ? 5.571   3.432   -0.246  0.46 14.21 ? 110 GLU A C   1 
ATOM   648  O O   A GLU A 1 85  ? 6.606   3.817   0.350   0.54 18.05 ? 110 GLU A O   1 
ATOM   649  O O   B GLU A 1 85  ? 6.573   3.810   0.373   0.46 18.00 ? 110 GLU A O   1 
ATOM   650  C CB  A GLU A 1 85  ? 5.976   3.583   -2.733  0.54 16.73 ? 110 GLU A CB  1 
ATOM   651  C CB  B GLU A 1 85  ? 5.893   3.615   -2.738  0.46 16.75 ? 110 GLU A CB  1 
ATOM   652  C CG  A GLU A 1 85  ? 4.924   4.665   -2.902  0.54 13.64 ? 110 GLU A CG  1 
ATOM   653  C CG  B GLU A 1 85  ? 6.550   2.952   -3.946  0.46 23.74 ? 110 GLU A CG  1 
ATOM   654  C CD  A GLU A 1 85  ? 5.118   5.495   -4.162  0.54 18.18 ? 110 GLU A CD  1 
ATOM   655  C CD  B GLU A 1 85  ? 6.747   3.889   -5.128  0.46 25.73 ? 110 GLU A CD  1 
ATOM   656  O OE1 A GLU A 1 85  ? 6.021   5.170   -4.961  0.54 26.12 ? 110 GLU A OE1 1 
ATOM   657  O OE1 B GLU A 1 85  ? 6.202   5.013   -5.100  0.46 26.10 ? 110 GLU A OE1 1 
ATOM   658  O OE2 A GLU A 1 85  ? 4.371   6.477   -4.351  0.54 26.85 ? 110 GLU A OE2 1 
ATOM   659  O OE2 B GLU A 1 85  ? 7.439   3.488   -6.095  0.46 20.00 ? 110 GLU A OE2 1 
ATOM   660  N N   A LYS A 1 86  ? 4.362   3.645   0.204   0.54 14.24 ? 111 LYS A N   1 
ATOM   661  N N   B LYS A 1 86  ? 4.332   3.644   0.208   0.46 14.23 ? 111 LYS A N   1 
ATOM   662  C CA  A LYS A 1 86  ? 4.125   4.312   1.479   0.54 15.72 ? 111 LYS A CA  1 
ATOM   663  C CA  B LYS A 1 86  ? 4.110   4.315   1.484   0.46 15.73 ? 111 LYS A CA  1 
ATOM   664  C C   A LYS A 1 86  ? 4.530   3.450   2.670   0.54 14.58 ? 111 LYS A C   1 
ATOM   665  C C   B LYS A 1 86  ? 4.489   3.448   2.679   0.46 14.61 ? 111 LYS A C   1 
ATOM   666  O O   A LYS A 1 86  ? 4.803   3.992   3.746   0.54 15.48 ? 111 LYS A O   1 
ATOM   667  O O   B LYS A 1 86  ? 4.683   3.986   3.774   0.46 15.23 ? 111 LYS A O   1 
ATOM   668  C CB  A LYS A 1 86  ? 2.642   4.691   1.589   0.54 15.20 ? 111 LYS A CB  1 
ATOM   669  C CB  B LYS A 1 86  ? 2.641   4.731   1.628   0.46 15.16 ? 111 LYS A CB  1 
ATOM   670  C CG  A LYS A 1 86  ? 2.203   5.306   2.914   0.54 17.37 ? 111 LYS A CG  1 
ATOM   671  C CG  B LYS A 1 86  ? 2.050   5.485   0.441   0.46 18.21 ? 111 LYS A CG  1 
ATOM   672  C CD  A LYS A 1 86  ? 0.810   5.924   2.788   0.54 15.77 ? 111 LYS A CD  1 
ATOM   673  C CD  B LYS A 1 86  ? 0.524   5.356   0.446   0.46 21.83 ? 111 LYS A CD  1 
ATOM   674  C CE  A LYS A 1 86  ? 0.317   6.450   4.127   0.54 22.34 ? 111 LYS A CE  1 
ATOM   675  C CE  B LYS A 1 86  ? -0.138  6.315   -0.529  0.46 22.81 ? 111 LYS A CE  1 
ATOM   676  N NZ  A LYS A 1 86  ? -0.647  7.572   3.956   0.54 20.76 ? 111 LYS A NZ  1 
ATOM   677  N NZ  B LYS A 1 86  ? -1.598  6.472   -0.262  0.46 24.25 ? 111 LYS A NZ  1 
ATOM   678  N N   . HIS A 1 87  ? 4.579   2.126   2.506   1.00 11.91 ? 112 HIS A N   1 
ATOM   679  C CA  . HIS A 1 87  ? 4.790   1.214   3.625   1.00 12.01 ? 112 HIS A CA  1 
ATOM   680  C C   . HIS A 1 87  ? 6.076   0.412   3.515   1.00 11.82 ? 112 HIS A C   1 
ATOM   681  O O   . HIS A 1 87  ? 6.265   -0.551  4.271   1.00 14.88 ? 112 HIS A O   1 
ATOM   682  C CB  . HIS A 1 87  ? 3.578   0.287   3.747   1.00 14.76 ? 112 HIS A CB  1 
ATOM   683  C CG  . HIS A 1 87  ? 2.291   1.033   3.876   1.00 15.70 ? 112 HIS A CG  1 
ATOM   684  N ND1 . HIS A 1 87  ? 1.893   1.627   5.055   1.00 21.35 ? 112 HIS A ND1 1 
ATOM   685  C CD2 . HIS A 1 87  ? 1.342   1.339   2.962   1.00 15.65 ? 112 HIS A CD2 1 
ATOM   686  C CE1 . HIS A 1 87  ? 0.740   2.245   4.867   1.00 18.29 ? 112 HIS A CE1 1 
ATOM   687  N NE2 . HIS A 1 87  ? 0.384   2.086   3.606   1.00 20.15 ? 112 HIS A NE2 1 
ATOM   688  N N   . VAL A 1 88  ? 6.962   0.787   2.594   1.00 11.66 ? 113 VAL A N   1 
ATOM   689  C CA  . VAL A 1 88  ? 8.278   0.168   2.501   1.00 12.85 ? 113 VAL A CA  1 
ATOM   690  C C   . VAL A 1 88  ? 8.969   0.242   3.857   1.00 12.03 ? 113 VAL A C   1 
ATOM   691  O O   . VAL A 1 88  ? 8.797   1.205   4.612   1.00 12.67 ? 113 VAL A O   1 
ATOM   692  C CB  . VAL A 1 88  ? 9.100   0.861   1.399   1.00 17.39 ? 113 VAL A CB  1 
ATOM   693  C CG1 . VAL A 1 88  ? 10.514  0.294   1.318   1.00 25.27 ? 113 VAL A CG1 1 
ATOM   694  C CG2 . VAL A 1 88  ? 8.409   0.725   0.065   1.00 19.96 ? 113 VAL A CG2 1 
ATOM   695  N N   . ASN A 1 89  ? 9.727   -0.809  4.178   1.00 13.73 ? 114 ASN A N   1 
ATOM   696  C CA  . ASN A 1 89  ? 10.395  -1.003  5.469   1.00 11.74 ? 114 ASN A CA  1 
ATOM   697  C C   . ASN A 1 89  ? 9.407   -1.138  6.614   1.00 16.43 ? 114 ASN A C   1 
ATOM   698  O O   . ASN A 1 89  ? 9.775   -0.981  7.781   1.00 16.16 ? 114 ASN A O   1 
ATOM   699  C CB  . ASN A 1 89  ? 11.407  0.108   5.758   1.00 13.14 ? 114 ASN A CB  1 
ATOM   700  C CG  . ASN A 1 89  ? 12.583  0.043   4.827   1.00 13.31 ? 114 ASN A CG  1 
ATOM   701  O OD1 . ASN A 1 89  ? 13.132  -1.029  4.617   1.00 13.59 ? 114 ASN A OD1 1 
ATOM   702  N ND2 . ASN A 1 89  ? 12.963  1.172   4.250   1.00 14.46 ? 114 ASN A ND2 1 
ATOM   703  N N   . GLY A 1 90  ? 8.160   -1.440  6.288   1.00 12.51 ? 115 GLY A N   1 
ATOM   704  C CA  . GLY A 1 90  ? 7.159   -1.779  7.274   1.00 12.42 ? 115 GLY A CA  1 
ATOM   705  C C   . GLY A 1 90  ? 6.316   -2.923  6.754   1.00 11.65 ? 115 GLY A C   1 
ATOM   706  O O   . GLY A 1 90  ? 6.796   -3.718  5.946   1.00 12.41 ? 115 GLY A O   1 
ATOM   707  N N   . THR A 1 91  ? 5.058   -3.008  7.175   1.00 12.81 ? 116 THR A N   1 
ATOM   708  C CA  . THR A 1 91  ? 4.196   -4.105  6.764   1.00 11.19 ? 116 THR A CA  1 
ATOM   709  C C   . THR A 1 91  ? 2.852   -3.560  6.290   1.00 9.71  ? 116 THR A C   1 
ATOM   710  O O   . THR A 1 91  ? 2.460   -2.435  6.605   1.00 12.10 ? 116 THR A O   1 
ATOM   711  C CB  . THR A 1 91  ? 3.952   -5.118  7.907   1.00 15.42 ? 116 THR A CB  1 
ATOM   712  O OG1 . THR A 1 91  ? 3.353   -4.456  9.032   1.00 15.18 ? 116 THR A OG1 1 
ATOM   713  C CG2 . THR A 1 91  ? 5.258   -5.751  8.361   1.00 18.56 ? 116 THR A CG2 1 
ATOM   714  N N   . MET A 1 92  ? 2.165   -4.379  5.491   1.00 9.32  ? 117 MET A N   1 
ATOM   715  C CA  . MET A 1 92  ? 0.746   -4.239  5.171   1.00 13.89 ? 117 MET A CA  1 
ATOM   716  C C   . MET A 1 92  ? 0.029   -5.561  5.396   1.00 9.00  ? 117 MET A C   1 
ATOM   717  O O   . MET A 1 92  ? 0.625   -6.629  5.255   1.00 12.49 ? 117 MET A O   1 
ATOM   718  C CB  . MET A 1 92  ? 0.507   -3.748  3.735   1.00 12.79 ? 117 MET A CB  1 
ATOM   719  C CG  . MET A 1 92  ? 1.448   -2.670  3.267   1.00 13.06 ? 117 MET A CG  1 
ATOM   720  S SD  . MET A 1 92  ? 1.183   -2.184  1.533   1.00 13.08 ? 117 MET A SD  1 
ATOM   721  C CE  . MET A 1 92  ? -0.589  -1.958  1.396   1.00 14.03 ? 117 MET A CE  1 
ATOM   722  N N   . THR A 1 93  ? -1.251  -5.487  5.752   1.00 10.36 ? 118 THR A N   1 
ATOM   723  C CA  . THR A 1 93  ? -1.984  -6.735  5.921   1.00 9.95  ? 118 THR A CA  1 
ATOM   724  C C   . THR A 1 93  ? -2.460  -7.254  4.569   1.00 10.87 ? 118 THR A C   1 
ATOM   725  O O   . THR A 1 93  ? -2.478  -6.538  3.569   1.00 10.40 ? 118 THR A O   1 
ATOM   726  C CB  . THR A 1 93  ? -3.184  -6.562  6.846   1.00 12.52 ? 118 THR A CB  1 
ATOM   727  O OG1 . THR A 1 93  ? -4.166  -5.742  6.205   1.00 10.56 ? 118 THR A OG1 1 
ATOM   728  C CG2 . THR A 1 93  ? -2.759  -5.928  8.166   1.00 12.43 ? 118 THR A CG2 1 
ATOM   729  N N   . LEU A 1 94  ? -2.846  -8.523  4.535   1.00 10.33 ? 119 LEU A N   1 
ATOM   730  C CA  . LEU A 1 94  ? -3.337  -9.052  3.267   1.00 8.49  ? 119 LEU A CA  1 
ATOM   731  C C   . LEU A 1 94  ? -4.612  -8.353  2.809   1.00 9.97  ? 119 LEU A C   1 
ATOM   732  O O   . LEU A 1 94  ? -4.833  -8.216  1.605   1.00 10.80 ? 119 LEU A O   1 
ATOM   733  C CB  . LEU A 1 94  ? -3.554  -10.557 3.365   1.00 10.16 ? 119 LEU A CB  1 
ATOM   734  C CG  . LEU A 1 94  ? -2.262  -11.357 3.256   1.00 8.21  ? 119 LEU A CG  1 
ATOM   735  C CD1 . LEU A 1 94  ? -2.531  -12.805 3.652   1.00 11.95 ? 119 LEU A CD1 1 
ATOM   736  C CD2 . LEU A 1 94  ? -1.665  -11.293 1.843   1.00 9.91  ? 119 LEU A CD2 1 
ATOM   737  N N   . ALA A 1 95  ? -5.449  -7.877  3.741   1.00 10.03 ? 120 ALA A N   1 
ATOM   738  C CA  . ALA A 1 95  ? -6.597  -7.078  3.331   1.00 8.86  ? 120 ALA A CA  1 
ATOM   739  C C   . ALA A 1 95  ? -6.157  -5.759  2.714   1.00 10.75 ? 120 ALA A C   1 
ATOM   740  O O   . ALA A 1 95  ? -6.701  -5.335  1.686   1.00 10.90 ? 120 ALA A O   1 
ATOM   741  C CB  . ALA A 1 95  ? -7.521  -6.818  4.519   1.00 12.39 ? 120 ALA A CB  1 
ATOM   742  N N   . GLU A 1 96  ? -5.166  -5.107  3.323   1.00 10.66 ? 121 GLU A N   1 
ATOM   743  C CA  . GLU A 1 96  ? -4.647  -3.856  2.771   1.00 9.80  ? 121 GLU A CA  1 
ATOM   744  C C   . GLU A 1 96  ? -4.005  -4.075  1.404   1.00 8.60  ? 121 GLU A C   1 
ATOM   745  O O   . GLU A 1 96  ? -4.146  -3.235  0.505   1.00 10.59 ? 121 GLU A O   1 
ATOM   746  C CB  . GLU A 1 96  ? -3.657  -3.236  3.754   1.00 10.93 ? 121 GLU A CB  1 
ATOM   747  C CG  . GLU A 1 96  ? -4.377  -2.616  4.957   1.00 10.85 ? 121 GLU A CG  1 
ATOM   748  C CD  . GLU A 1 96  ? -3.488  -2.461  6.181   1.00 18.67 ? 121 GLU A CD  1 
ATOM   749  O OE1 . GLU A 1 96  ? -2.284  -2.752  6.095   1.00 13.15 ? 121 GLU A OE1 1 
ATOM   750  O OE2 . GLU A 1 96  ? -4.012  -2.051  7.245   1.00 22.22 ? 121 GLU A OE2 1 
ATOM   751  N N   . LEU A 1 97  ? -3.323  -5.205  1.224   1.00 8.06  ? 122 LEU A N   1 
ATOM   752  C CA  . LEU A 1 97  ? -2.718  -5.518  -0.066  1.00 9.01  ? 122 LEU A CA  1 
ATOM   753  C C   . LEU A 1 97  ? -3.785  -5.817  -1.113  1.00 7.44  ? 122 LEU A C   1 
ATOM   754  O O   . LEU A 1 97  ? -3.652  -5.400  -2.269  1.00 8.27  ? 122 LEU A O   1 
ATOM   755  C CB  . LEU A 1 97  ? -1.761  -6.694  0.100   1.00 8.04  ? 122 LEU A CB  1 
ATOM   756  C CG  . LEU A 1 97  ? -0.497  -6.334  0.885   1.00 8.10  ? 122 LEU A CG  1 
ATOM   757  C CD1 . LEU A 1 97  ? 0.128   -7.556  1.535   1.00 9.54  ? 122 LEU A CD1 1 
ATOM   758  C CD2 . LEU A 1 97  ? 0.500   -5.595  -0.004  1.00 11.53 ? 122 LEU A CD2 1 
ATOM   759  N N   . SER A 1 98  ? -4.852  -6.525  -0.722  1.00 8.83  ? 123 SER A N   1 
ATOM   760  C CA  . SER A 1 98  ? -5.943  -6.808  -1.653  1.00 8.98  ? 123 SER A CA  1 
ATOM   761  C C   . SER A 1 98  ? -6.613  -5.525  -2.112  1.00 8.54  ? 123 SER A C   1 
ATOM   762  O O   . SER A 1 98  ? -6.873  -5.334  -3.306  1.00 8.22  ? 123 SER A O   1 
ATOM   763  C CB  . SER A 1 98  ? -6.965  -7.739  -1.007  1.00 10.28 ? 123 SER A CB  1 
ATOM   764  O OG  . SER A 1 98  ? -6.394  -9.001  -0.718  1.00 11.93 ? 123 SER A OG  1 
ATOM   765  N N   . ALA A 1 99  ? -6.893  -4.621  -1.169  1.00 8.56  ? 124 ALA A N   1 
ATOM   766  C CA  . ALA A 1 99  ? -7.513  -3.349  -1.520  1.00 8.31  ? 124 ALA A CA  1 
ATOM   767  C C   . ALA A 1 99  ? -6.595  -2.502  -2.401  1.00 10.67 ? 124 ALA A C   1 
ATOM   768  O O   . ALA A 1 99  ? -7.064  -1.851  -3.345  1.00 10.23 ? 124 ALA A O   1 
ATOM   769  C CB  . ALA A 1 99  ? -7.898  -2.599  -0.238  1.00 9.93  ? 124 ALA A CB  1 
ATOM   770  N N   . ALA A 1 100 ? -5.289  -2.485  -2.103  1.00 9.10  ? 125 ALA A N   1 
ATOM   771  C CA  . ALA A 1 100 ? -4.349  -1.722  -2.925  1.00 6.82  ? 125 ALA A CA  1 
ATOM   772  C C   . ALA A 1 100 ? -4.279  -2.277  -4.339  1.00 9.35  ? 125 ALA A C   1 
ATOM   773  O O   . ALA A 1 100 ? -4.274  -1.514  -5.312  1.00 9.34  ? 125 ALA A O   1 
ATOM   774  C CB  . ALA A 1 100 ? -2.956  -1.730  -2.289  1.00 8.32  ? 125 ALA A CB  1 
ATOM   775  N N   . ALA A 1 101 ? -4.215  -3.604  -4.471  1.00 7.80  ? 126 ALA A N   1 
ATOM   776  C CA  . ALA A 1 101 ? -4.211  -4.217  -5.792  1.00 5.90  ? 126 ALA A CA  1 
ATOM   777  C C   . ALA A 1 101 ? -5.476  -3.873  -6.566  1.00 10.22 ? 126 ALA A C   1 
ATOM   778  O O   . ALA A 1 101 ? -5.417  -3.470  -7.733  1.00 8.93  ? 126 ALA A O   1 
ATOM   779  C CB  . ALA A 1 101 ? -4.063  -5.734  -5.665  1.00 7.36  ? 126 ALA A CB  1 
ATOM   780  N N   . LEU A 1 102 ? -6.629  -4.040  -5.942  1.00 8.88  ? 127 LEU A N   1 
ATOM   781  C CA  . LEU A 1 102 ? -7.869  -3.889  -6.691  1.00 8.48  ? 127 LEU A CA  1 
ATOM   782  C C   . LEU A 1 102 ? -8.199  -2.426  -6.962  1.00 8.21  ? 127 LEU A C   1 
ATOM   783  O O   . LEU A 1 102 ? -8.627  -2.082  -8.068  1.00 10.79 ? 127 LEU A O   1 
ATOM   784  C CB  . LEU A 1 102 ? -9.019  -4.553  -5.939  1.00 8.18  ? 127 LEU A CB  1 
ATOM   785  C CG  . LEU A 1 102 ? -8.975  -6.077  -5.874  1.00 7.82  ? 127 LEU A CG  1 
ATOM   786  C CD1 . LEU A 1 102 ? -10.101 -6.543  -5.013  1.00 10.98 ? 127 LEU A CD1 1 
ATOM   787  C CD2 . LEU A 1 102 ? -9.046  -6.692  -7.286  1.00 11.50 ? 127 LEU A CD2 1 
ATOM   788  N N   . GLN A 1 103 ? -8.006  -1.542  -5.980  1.00 7.77  ? 128 GLN A N   1 
ATOM   789  C CA  . GLN A 1 103 ? -8.534  -0.196  -6.136  1.00 7.81  ? 128 GLN A CA  1 
ATOM   790  C C   . GLN A 1 103 ? -7.516  0.800   -6.659  1.00 8.64  ? 128 GLN A C   1 
ATOM   791  O O   . GLN A 1 103 ? -7.915  1.855   -7.163  1.00 9.86  ? 128 GLN A O   1 
ATOM   792  C CB  . GLN A 1 103 ? -9.103  0.304   -4.803  1.00 10.11 ? 128 GLN A CB  1 
ATOM   793  C CG  . GLN A 1 103 ? -10.114 -0.650  -4.208  1.00 7.57  ? 128 GLN A CG  1 
ATOM   794  C CD  . GLN A 1 103 ? -10.814 -0.070  -3.008  1.00 8.73  ? 128 GLN A CD  1 
ATOM   795  O OE1 . GLN A 1 103 ? -10.171 0.562   -2.158  1.00 12.64 ? 128 GLN A OE1 1 
ATOM   796  N NE2 . GLN A 1 103 ? -12.121 -0.295  -2.911  1.00 8.52  ? 128 GLN A NE2 1 
ATOM   797  N N   . TYR A 1 104 ? -6.224  0.487   -6.559  1.00 6.85  ? 129 TYR A N   1 
ATOM   798  C CA  . TYR A 1 104 ? -5.170  1.344   -7.091  1.00 10.85 ? 129 TYR A CA  1 
ATOM   799  C C   . TYR A 1 104 ? -4.300  0.645   -8.120  1.00 9.06  ? 129 TYR A C   1 
ATOM   800  O O   . TYR A 1 104 ? -3.390  1.277   -8.682  1.00 11.52 ? 129 TYR A O   1 
ATOM   801  C CB  . TYR A 1 104 ? -4.298  1.875   -5.940  1.00 9.77  ? 129 TYR A CB  1 
ATOM   802  C CG  . TYR A 1 104 ? -5.103  2.755   -5.014  1.00 10.28 ? 129 TYR A CG  1 
ATOM   803  C CD1 . TYR A 1 104 ? -5.833  2.209   -3.970  1.00 13.16 ? 129 TYR A CD1 1 
ATOM   804  C CD2 . TYR A 1 104 ? -5.161  4.132   -5.214  1.00 9.84  ? 129 TYR A CD2 1 
ATOM   805  C CE1 . TYR A 1 104 ? -6.592  3.006   -3.138  1.00 11.16 ? 129 TYR A CE1 1 
ATOM   806  C CE2 . TYR A 1 104 ? -5.929  4.945   -4.387  1.00 12.03 ? 129 TYR A CE2 1 
ATOM   807  C CZ  . TYR A 1 104 ? -6.636  4.377   -3.354  1.00 11.75 ? 129 TYR A CZ  1 
ATOM   808  O OH  . TYR A 1 104 ? -7.394  5.170   -2.520  1.00 14.55 ? 129 TYR A OH  1 
ATOM   809  N N   . SER A 1 105 ? -4.560  -0.632  -8.395  1.00 8.04  ? 130 SER A N   1 
ATOM   810  C CA  . SER A 1 105 ? -3.791  -1.414  -9.363  1.00 9.31  ? 130 SER A CA  1 
ATOM   811  C C   . SER A 1 105 ? -2.316  -1.478  -8.976  1.00 10.22 ? 130 SER A C   1 
ATOM   812  O O   . SER A 1 105 ? -1.427  -1.496  -9.832  1.00 11.75 ? 130 SER A O   1 
ATOM   813  C CB  . SER A 1 105 ? -3.963  -0.887  -10.787 1.00 11.90 ? 130 SER A CB  1 
ATOM   814  O OG  . SER A 1 105 ? -3.945  -1.983  -11.690 1.00 11.19 ? 130 SER A OG  1 
ATOM   815  N N   . ASP A 1 106 ? -2.064  -1.564  -7.670  1.00 8.77  ? 131 ASP A N   1 
ATOM   816  C CA  . ASP A 1 106 ? -0.701  -1.639  -7.154  1.00 8.40  ? 131 ASP A CA  1 
ATOM   817  C C   . ASP A 1 106 ? -0.051  -2.985  -7.494  1.00 9.66  ? 131 ASP A C   1 
ATOM   818  O O   . ASP A 1 106 ? -0.538  -4.046  -7.087  1.00 9.33  ? 131 ASP A O   1 
ATOM   819  C CB  . ASP A 1 106 ? -0.735  -1.392  -5.640  1.00 8.10  ? 131 ASP A CB  1 
ATOM   820  C CG  . ASP A 1 106 ? 0.652   -1.237  -5.032  1.00 10.15 ? 131 ASP A CG  1 
ATOM   821  O OD1 . ASP A 1 106 ? 1.495   -2.136  -5.195  1.00 11.04 ? 131 ASP A OD1 1 
ATOM   822  O OD2 . ASP A 1 106 ? 0.909   -0.207  -4.375  1.00 11.79 ? 131 ASP A OD2 1 
ATOM   823  N N   . ASN A 1 107 ? 1.078   -2.933  -8.212  1.00 8.38  ? 132 ASN A N   1 
ATOM   824  C CA  . ASN A 1 107 ? 1.720   -4.146  -8.710  1.00 10.20 ? 132 ASN A CA  1 
ATOM   825  C C   . ASN A 1 107 ? 2.536   -4.853  -7.639  1.00 10.56 ? 132 ASN A C   1 
ATOM   826  O O   . ASN A 1 107 ? 2.666   -6.082  -7.683  1.00 9.10  ? 132 ASN A O   1 
ATOM   827  C CB  . ASN A 1 107 ? 2.622   -3.806  -9.900  1.00 8.33  ? 132 ASN A CB  1 
ATOM   828  C CG  . ASN A 1 107 ? 1.837   -3.587  -11.172 1.00 13.21 ? 132 ASN A CG  1 
ATOM   829  O OD1 . ASN A 1 107 ? 0.648   -3.866  -11.229 1.00 12.30 ? 132 ASN A OD1 1 
ATOM   830  N ND2 . ASN A 1 107 ? 2.503   -3.067  -12.205 1.00 14.79 ? 132 ASN A ND2 1 
ATOM   831  N N   . THR A 1 108 ? 3.108   -4.114  -6.683  1.00 9.20  ? 133 THR A N   1 
ATOM   832  C CA  . THR A 1 108 ? 3.756   -4.784  -5.560  1.00 11.05 ? 133 THR A CA  1 
ATOM   833  C C   . THR A 1 108 ? 2.725   -5.522  -4.719  1.00 9.93  ? 133 THR A C   1 
ATOM   834  O O   . THR A 1 108 ? 2.972   -6.648  -4.266  1.00 9.72  ? 133 THR A O   1 
ATOM   835  C CB  . THR A 1 108 ? 4.535   -3.785  -4.699  1.00 13.31 ? 133 THR A CB  1 
ATOM   836  O OG1 . THR A 1 108 ? 5.603   -3.226  -5.467  1.00 13.51 ? 133 THR A OG1 1 
ATOM   837  C CG2 . THR A 1 108 ? 5.137   -4.488  -3.490  1.00 12.21 ? 133 THR A CG2 1 
ATOM   838  N N   . ALA A 1 109 ? 1.558   -4.911  -4.511  1.00 8.33  ? 134 ALA A N   1 
ATOM   839  C CA  . ALA A 1 109 ? 0.505   -5.594  -3.767  1.00 8.24  ? 134 ALA A CA  1 
ATOM   840  C C   . ALA A 1 109 ? 0.107   -6.895  -4.461  1.00 8.73  ? 134 ALA A C   1 
ATOM   841  O O   . ALA A 1 109 ? -0.026  -7.939  -3.813  1.00 10.54 ? 134 ALA A O   1 
ATOM   842  C CB  . ALA A 1 109 ? -0.701  -4.667  -3.581  1.00 8.14  ? 134 ALA A CB  1 
ATOM   843  N N   . MET A 1 110 ? -0.089  -6.853  -5.783  1.00 9.15  ? 135 MET A N   1 
ATOM   844  C CA  . MET A 1 110 ? -0.292  -8.087  -6.544  1.00 7.99  ? 135 MET A CA  1 
ATOM   845  C C   . MET A 1 110 ? 0.743   -9.149  -6.245  1.00 11.34 ? 135 MET A C   1 
ATOM   846  O O   . MET A 1 110 ? 0.398   -10.318 -6.020  1.00 9.68  ? 135 MET A O   1 
ATOM   847  C CB  . MET A 1 110 ? -0.340  -7.812  -8.047  1.00 7.98  ? 135 MET A CB  1 
ATOM   848  C CG  . MET A 1 110 ? -0.571  -9.112  -8.824  1.00 8.34  ? 135 MET A CG  1 
ATOM   849  S SD  . MET A 1 110 ? -2.063  -10.060 -8.465  1.00 9.53  ? 135 MET A SD  1 
ATOM   850  C CE  . MET A 1 110 ? -2.327  -10.806 -10.075 1.00 10.18 ? 135 MET A CE  1 
ATOM   851  N N   . ASN A 1 111 ? 2.015   -8.774  -6.264  1.00 7.78  ? 136 ASN A N   1 
ATOM   852  C CA  . ASN A 1 111 ? 3.051   -9.778  -6.073  1.00 9.05  ? 136 ASN A CA  1 
ATOM   853  C C   . ASN A 1 111 ? 2.962   -10.409 -4.697  1.00 10.16 ? 136 ASN A C   1 
ATOM   854  O O   . ASN A 1 111 ? 3.240   -11.603 -4.554  1.00 10.92 ? 136 ASN A O   1 
ATOM   855  C CB  . ASN A 1 111 ? 4.433   -9.171  -6.332  1.00 8.89  ? 136 ASN A CB  1 
ATOM   856  C CG  . ASN A 1 111 ? 4.756   -9.105  -7.814  1.00 11.73 ? 136 ASN A CG  1 
ATOM   857  O OD1 . ASN A 1 111 ? 4.031   -9.675  -8.646  1.00 12.41 ? 136 ASN A OD1 1 
ATOM   858  N ND2 . ASN A 1 111 ? 5.822   -8.392  -8.163  1.00 10.54 ? 136 ASN A ND2 1 
ATOM   859  N N   . LYS A 1 112 ? 2.543   -9.645  -3.682  1.00 9.17  ? 137 LYS A N   1 
ATOM   860  C CA  . LYS A 1 112 ? 2.346   -10.232 -2.357  1.00 9.14  ? 137 LYS A CA  1 
ATOM   861  C C   . LYS A 1 112 ? 1.158   -11.187 -2.342  1.00 9.20  ? 137 LYS A C   1 
ATOM   862  O O   . LYS A 1 112 ? 1.199   -12.223 -1.666  1.00 11.39 ? 137 LYS A O   1 
ATOM   863  C CB  . LYS A 1 112 ? 2.159   -9.134  -1.308  1.00 10.08 ? 137 LYS A CB  1 
ATOM   864  C CG  . LYS A 1 112 ? 3.359   -8.213  -1.133  1.00 10.81 ? 137 LYS A CG  1 
ATOM   865  C CD  . LYS A 1 112 ? 4.624   -9.014  -0.851  1.00 13.83 ? 137 LYS A CD  1 
ATOM   866  C CE  . LYS A 1 112 ? 5.774   -8.103  -0.409  1.00 15.32 ? 137 LYS A CE  1 
ATOM   867  N NZ  . LYS A 1 112 ? 7.099   -8.766  -0.544  1.00 20.66 ? 137 LYS A NZ  1 
ATOM   868  N N   . LEU A 1 113 ? 0.091   -10.865 -3.077  1.00 8.76  ? 138 LEU A N   1 
ATOM   869  C CA  . LEU A 1 113 ? -1.025  -11.805 -3.184  1.00 8.80  ? 138 LEU A CA  1 
ATOM   870  C C   . LEU A 1 113 ? -0.571  -13.091 -3.862  1.00 9.55  ? 138 LEU A C   1 
ATOM   871  O O   . LEU A 1 113 ? -0.881  -14.195 -3.403  1.00 9.50  ? 138 LEU A O   1 
ATOM   872  C CB  . LEU A 1 113 ? -2.177  -11.180 -3.966  1.00 9.88  ? 138 LEU A CB  1 
ATOM   873  C CG  . LEU A 1 113 ? -2.739  -9.886  -3.379  1.00 8.44  ? 138 LEU A CG  1 
ATOM   874  C CD1 . LEU A 1 113 ? -3.884  -9.418  -4.243  1.00 9.42  ? 138 LEU A CD1 1 
ATOM   875  C CD2 . LEU A 1 113 ? -3.209  -10.116 -1.935  1.00 9.88  ? 138 LEU A CD2 1 
ATOM   876  N N   . ILE A 1 114 ? 0.177   -12.957 -4.963  1.00 8.74  ? 139 ILE A N   1 
ATOM   877  C CA  . ILE A 1 114 ? 0.676   -14.130 -5.676  1.00 9.59  ? 139 ILE A CA  1 
ATOM   878  C C   . ILE A 1 114 ? 1.542   -14.976 -4.757  1.00 10.31 ? 139 ILE A C   1 
ATOM   879  O O   . ILE A 1 114 ? 1.399   -16.206 -4.705  1.00 10.71 ? 139 ILE A O   1 
ATOM   880  C CB  . ILE A 1 114 ? 1.432   -13.702 -6.947  1.00 8.36  ? 139 ILE A CB  1 
ATOM   881  C CG1 . ILE A 1 114 ? 0.471   -13.088 -7.978  1.00 9.30  ? 139 ILE A CG1 1 
ATOM   882  C CG2 . ILE A 1 114 ? 2.169   -14.895 -7.566  1.00 8.71  ? 139 ILE A CG2 1 
ATOM   883  C CD1 . ILE A 1 114 ? 1.199   -12.424 -9.155  1.00 8.32  ? 139 ILE A CD1 1 
ATOM   884  N N   . ALA A 1 115 ? 2.427   -14.331 -3.990  1.00 11.56 ? 140 ALA A N   1 
ATOM   885  C CA  . ALA A 1 115 ? 3.302   -15.080 -3.094  1.00 13.09 ? 140 ALA A CA  1 
ATOM   886  C C   . ALA A 1 115 ? 2.504   -15.806 -2.018  1.00 13.27 ? 140 ALA A C   1 
ATOM   887  O O   . ALA A 1 115 ? 2.818   -16.955 -1.675  1.00 11.47 ? 140 ALA A O   1 
ATOM   888  C CB  . ALA A 1 115 ? 4.338   -14.147 -2.465  1.00 12.34 ? 140 ALA A CB  1 
ATOM   889  N N   . GLN A 1 116 ? 1.460   -15.161 -1.477  1.00 10.56 ? 141 GLN A N   1 
ATOM   890  C CA  . GLN A 1 116 ? 0.629   -15.813 -0.469  1.00 9.48  ? 141 GLN A CA  1 
ATOM   891  C C   . GLN A 1 116 ? 0.009   -17.096 -1.003  1.00 9.25  ? 141 GLN A C   1 
ATOM   892  O O   . GLN A 1 116 ? -0.152  -18.077 -0.260  1.00 11.95 ? 141 GLN A O   1 
ATOM   893  C CB  . GLN A 1 116 ? -0.447  -14.840 0.013   1.00 8.79  ? 141 GLN A CB  1 
ATOM   894  C CG  . GLN A 1 116 ? -1.607  -15.441 0.831   1.00 9.55  ? 141 GLN A CG  1 
ATOM   895  C CD  . GLN A 1 116 ? -1.149  -16.173 2.065   1.00 9.35  ? 141 GLN A CD  1 
ATOM   896  O OE1 . GLN A 1 116 ? -0.147  -15.802 2.688   1.00 12.89 ? 141 GLN A OE1 1 
ATOM   897  N NE2 . GLN A 1 116 ? -1.877  -17.219 2.434   1.00 11.52 ? 141 GLN A NE2 1 
ATOM   898  N N   . LEU A 1 117 ? -0.313  -17.124 -2.289  1.00 10.29 ? 142 LEU A N   1 
ATOM   899  C CA  . LEU A 1 117 ? -0.929  -18.271 -2.936  1.00 8.99  ? 142 LEU A CA  1 
ATOM   900  C C   . LEU A 1 117 ? 0.077   -19.295 -3.434  1.00 12.43 ? 142 LEU A C   1 
ATOM   901  O O   . LEU A 1 117 ? -0.334  -20.310 -4.018  1.00 14.19 ? 142 LEU A O   1 
ATOM   902  C CB  . LEU A 1 117 ? -1.787  -17.791 -4.106  1.00 12.51 ? 142 LEU A CB  1 
ATOM   903  C CG  . LEU A 1 117 ? -2.881  -16.822 -3.654  1.00 11.54 ? 142 LEU A CG  1 
ATOM   904  C CD1 . LEU A 1 117 ? -3.466  -16.079 -4.844  1.00 11.86 ? 142 LEU A CD1 1 
ATOM   905  C CD2 . LEU A 1 117 ? -3.975  -17.541 -2.899  1.00 11.54 ? 142 LEU A CD2 1 
ATOM   906  N N   . GLY A 1 118 ? 1.373   -19.062 -3.212  1.00 11.02 ? 143 GLY A N   1 
ATOM   907  C CA  . GLY A 1 118 ? 2.420   -19.990 -3.593  1.00 12.99 ? 143 GLY A CA  1 
ATOM   908  C C   . GLY A 1 118 ? 3.000   -19.784 -4.972  1.00 12.36 ? 143 GLY A C   1 
ATOM   909  O O   . GLY A 1 118 ? 3.700   -20.677 -5.472  1.00 16.23 ? 143 GLY A O   1 
ATOM   910  N N   . GLY A 1 119 ? 2.742   -18.645 -5.606  1.00 10.86 ? 144 GLY A N   1 
ATOM   911  C CA  . GLY A 1 119 ? 3.227   -18.405 -6.942  1.00 10.52 ? 144 GLY A CA  1 
ATOM   912  C C   . GLY A 1 119 ? 2.069   -18.299 -7.904  1.00 10.28 ? 144 GLY A C   1 
ATOM   913  O O   . GLY A 1 119 ? 0.913   -18.553 -7.536  1.00 11.53 ? 144 GLY A O   1 
ATOM   914  N N   . PRO A 1 120 ? 2.356   -17.886 -9.150  1.00 10.02 ? 145 PRO A N   1 
ATOM   915  C CA  . PRO A 1 120 ? 1.274   -17.732 -10.142 1.00 10.10 ? 145 PRO A CA  1 
ATOM   916  C C   . PRO A 1 120 ? 0.410   -18.978 -10.296 1.00 11.94 ? 145 PRO A C   1 
ATOM   917  O O   . PRO A 1 120 ? -0.808  -18.864 -10.479 1.00 13.36 ? 145 PRO A O   1 
ATOM   918  C CB  . PRO A 1 120 ? 2.035   -17.397 -11.436 1.00 11.42 ? 145 PRO A CB  1 
ATOM   919  C CG  . PRO A 1 120 ? 3.326   -16.749 -10.961 1.00 10.87 ? 145 PRO A CG  1 
ATOM   920  C CD  . PRO A 1 120 ? 3.675   -17.497 -9.686  1.00 10.56 ? 145 PRO A CD  1 
ATOM   921  N N   . GLY A 1 121 ? 1.007   -20.168 -10.200 1.00 11.59 ? 146 GLY A N   1 
ATOM   922  C CA  . GLY A 1 121 ? 0.228   -21.391 -10.292 1.00 11.56 ? 146 GLY A CA  1 
ATOM   923  C C   . GLY A 1 121 ? -0.836  -21.518 -9.219  1.00 11.42 ? 146 GLY A C   1 
ATOM   924  O O   . GLY A 1 121 ? -1.837  -22.207 -9.414  1.00 12.25 ? 146 GLY A O   1 
ATOM   925  N N   . GLY A 1 122 ? -0.632  -20.875 -8.066  1.00 11.66 ? 147 GLY A N   1 
ATOM   926  C CA  . GLY A 1 122 ? -1.652  -20.881 -7.033  1.00 10.06 ? 147 GLY A CA  1 
ATOM   927  C C   . GLY A 1 122 ? -2.884  -20.083 -7.410  1.00 11.13 ? 147 GLY A C   1 
ATOM   928  O O   . GLY A 1 122 ? -3.999  -20.424 -7.000  1.00 11.42 ? 147 GLY A O   1 
ATOM   929  N N   . VAL A 1 123 ? -2.708  -19.015 -8.192  1.00 10.73 ? 148 VAL A N   1 
ATOM   930  C CA  . VAL A 1 123 ? -3.863  -18.278 -8.701  1.00 9.19  ? 148 VAL A CA  1 
ATOM   931  C C   . VAL A 1 123 ? -4.622  -19.123 -9.724  1.00 9.86  ? 148 VAL A C   1 
ATOM   932  O O   . VAL A 1 123 ? -5.862  -19.190 -9.697  1.00 9.26  ? 148 VAL A O   1 
ATOM   933  C CB  . VAL A 1 123 ? -3.432  -16.917 -9.290  1.00 9.93  ? 148 VAL A CB  1 
ATOM   934  C CG1 . VAL A 1 123 ? -4.652  -16.104 -9.705  1.00 10.05 ? 148 VAL A CG1 1 
ATOM   935  C CG2 . VAL A 1 123 ? -2.620  -16.102 -8.292  1.00 11.96 ? 148 VAL A CG2 1 
ATOM   936  N N   . THR A 1 124 ? -3.894  -19.769 -10.643 1.00 9.13  ? 149 THR A N   1 
ATOM   937  C CA  . THR A 1 124 ? -4.521  -20.661 -11.616 1.00 9.62  ? 149 THR A CA  1 
ATOM   938  C C   . THR A 1 124 ? -5.269  -21.790 -10.929 1.00 8.03  ? 149 THR A C   1 
ATOM   939  O O   . THR A 1 124 ? -6.378  -22.141 -11.337 1.00 8.61  ? 149 THR A O   1 
ATOM   940  C CB  . THR A 1 124 ? -3.473  -21.238 -12.559 1.00 9.57  ? 149 THR A CB  1 
ATOM   941  O OG1 . THR A 1 124 ? -2.715  -20.171 -13.132 1.00 11.17 ? 149 THR A OG1 1 
ATOM   942  C CG2 . THR A 1 124 ? -4.160  -22.026 -13.666 1.00 10.42 ? 149 THR A CG2 1 
ATOM   943  N N   . ALA A 1 125 ? -4.692  -22.338 -9.857  1.00 9.73  ? 150 ALA A N   1 
ATOM   944  C CA  . ALA A 1 125 ? -5.346  -23.431 -9.148  1.00 9.50  ? 150 ALA A CA  1 
ATOM   945  C C   . ALA A 1 125 ? -6.679  -22.993 -8.557  1.00 11.00 ? 150 ALA A C   1 
ATOM   946  O O   . ALA A 1 125 ? -7.649  -23.764 -8.564  1.00 10.79 ? 150 ALA A O   1 
ATOM   947  C CB  . ALA A 1 125 ? -4.435  -23.974 -8.048  1.00 12.00 ? 150 ALA A CB  1 
ATOM   948  N N   . PHE A 1 126 ? -6.750  -21.767 -8.033  1.00 9.54  ? 151 PHE A N   1 
ATOM   949  C CA  . PHE A 1 126 ? -8.034  -21.278 -7.541  1.00 8.75  ? 151 PHE A CA  1 
ATOM   950  C C   . PHE A 1 126 ? -9.035  -21.134 -8.683  1.00 7.74  ? 151 PHE A C   1 
ATOM   951  O O   . PHE A 1 126 ? -10.219 -21.470 -8.534  1.00 8.12  ? 151 PHE A O   1 
ATOM   952  C CB  . PHE A 1 126 ? -7.856  -19.936 -6.814  1.00 9.21  ? 151 PHE A CB  1 
ATOM   953  C CG  . PHE A 1 126 ? -9.162  -19.250 -6.504  1.00 7.85  ? 151 PHE A CG  1 
ATOM   954  C CD1 . PHE A 1 126 ? -9.988  -19.750 -5.523  1.00 7.05  ? 151 PHE A CD1 1 
ATOM   955  C CD2 . PHE A 1 126 ? -9.567  -18.130 -7.210  1.00 9.58  ? 151 PHE A CD2 1 
ATOM   956  C CE1 . PHE A 1 126 ? -11.210 -19.138 -5.231  1.00 10.22 ? 151 PHE A CE1 1 
ATOM   957  C CE2 . PHE A 1 126 ? -10.779 -17.499 -6.927  1.00 11.29 ? 151 PHE A CE2 1 
ATOM   958  C CZ  . PHE A 1 126 ? -11.605 -18.007 -5.941  1.00 9.07  ? 151 PHE A CZ  1 
ATOM   959  N N   . ALA A 1 127 ? -8.587  -20.609 -9.827  1.00 8.62  ? 152 ALA A N   1 
ATOM   960  C CA  . ALA A 1 127 ? -9.465  -20.542 -10.989 1.00 8.44  ? 152 ALA A CA  1 
ATOM   961  C C   . ALA A 1 127 ? -10.047 -21.914 -11.312 1.00 8.28  ? 152 ALA A C   1 
ATOM   962  O O   . ALA A 1 127 ? -11.258 -22.055 -11.521 1.00 8.53  ? 152 ALA A O   1 
ATOM   963  C CB  . ALA A 1 127 ? -8.691  -19.974 -12.182 1.00 9.28  ? 152 ALA A CB  1 
ATOM   964  N N   . ARG A 1 128 ? -9.196  -22.945 -11.332 1.00 9.53  ? 153 ARG A N   1 
ATOM   965  C CA  . ARG A 1 128 ? -9.703  -24.286 -11.618 1.00 9.87  ? 153 ARG A CA  1 
ATOM   966  C C   . ARG A 1 128 ? -10.696 -24.744 -10.556 1.00 10.53 ? 153 ARG A C   1 
ATOM   967  O O   . ARG A 1 128 ? -11.685 -25.421 -10.870 1.00 13.06 ? 153 ARG A O   1 
ATOM   968  C CB  . ARG A 1 128 ? -8.544  -25.271 -11.723 1.00 10.90 ? 153 ARG A CB  1 
ATOM   969  C CG  . ARG A 1 128 ? -7.551  -24.969 -12.837 1.00 8.98  ? 153 ARG A CG  1 
ATOM   970  C CD  . ARG A 1 128 ? -8.127  -25.168 -14.243 1.00 10.49 ? 153 ARG A CD  1 
ATOM   971  N NE  . ARG A 1 128 ? -7.117  -24.864 -15.251 1.00 11.12 ? 153 ARG A NE  1 
ATOM   972  C CZ  . ARG A 1 128 ? -6.876  -23.646 -15.716 1.00 12.94 ? 153 ARG A CZ  1 
ATOM   973  N NH1 . ARG A 1 128 ? -7.663  -22.622 -15.418 1.00 10.89 ? 153 ARG A NH1 1 
ATOM   974  N NH2 . ARG A 1 128 ? -5.795  -23.436 -16.462 1.00 12.84 ? 153 ARG A NH2 1 
ATOM   975  N N   . ALA A 1 129 ? -10.458 -24.367 -9.299  1.00 9.55  ? 154 ALA A N   1 
ATOM   976  C CA  . ALA A 1 129 ? -11.336 -24.787 -8.216  1.00 9.35  ? 154 ALA A CA  1 
ATOM   977  C C   . ALA A 1 129 ? -12.724 -24.171 -8.318  1.00 12.76 ? 154 ALA A C   1 
ATOM   978  O O   . ALA A 1 129 ? -13.684 -24.745 -7.792  1.00 17.07 ? 154 ALA A O   1 
ATOM   979  C CB  . ALA A 1 129 ? -10.704 -24.440 -6.867  1.00 11.51 ? 154 ALA A CB  1 
ATOM   980  N N   . ILE A 1 130 ? -12.866 -23.011 -8.957  1.00 10.93 ? 155 ILE A N   1 
ATOM   981  C CA  . ILE A 1 130 ? -14.174 -22.398 -9.122  1.00 11.62 ? 155 ILE A CA  1 
ATOM   982  C C   . ILE A 1 130 ? -14.714 -22.593 -10.541 1.00 13.28 ? 155 ILE A C   1 
ATOM   983  O O   . ILE A 1 130 ? -15.663 -21.913 -10.942 1.00 15.72 ? 155 ILE A O   1 
ATOM   984  C CB  . ILE A 1 130 ? -14.158 -20.915 -8.722  1.00 11.93 ? 155 ILE A CB  1 
ATOM   985  C CG1 . ILE A 1 130 ? -13.238 -20.104 -9.633  1.00 14.72 ? 155 ILE A CG1 1 
ATOM   986  C CG2 . ILE A 1 130 ? -13.706 -20.764 -7.264  1.00 14.00 ? 155 ILE A CG2 1 
ATOM   987  C CD1 . ILE A 1 130 ? -13.466 -18.611 -9.527  1.00 15.91 ? 155 ILE A CD1 1 
ATOM   988  N N   . GLY A 1 131 ? -14.139 -23.525 -11.298 1.00 12.29 ? 156 GLY A N   1 
ATOM   989  C CA  . GLY A 1 131 ? -14.709 -23.953 -12.560 1.00 11.44 ? 156 GLY A CA  1 
ATOM   990  C C   . GLY A 1 131 ? -14.205 -23.236 -13.785 1.00 10.82 ? 156 GLY A C   1 
ATOM   991  O O   . GLY A 1 131 ? -14.789 -23.405 -14.865 1.00 13.38 ? 156 GLY A O   1 
ATOM   992  N N   . ASP A 1 132 ? -13.156 -22.442 -13.654 1.00 9.99  ? 157 ASP A N   1 
ATOM   993  C CA  . ASP A 1 132 ? -12.566 -21.710 -14.769 1.00 9.79  ? 157 ASP A CA  1 
ATOM   994  C C   . ASP A 1 132 ? -11.388 -22.528 -15.273 1.00 9.08  ? 157 ASP A C   1 
ATOM   995  O O   . ASP A 1 132 ? -10.346 -22.590 -14.619 1.00 9.61  ? 157 ASP A O   1 
ATOM   996  C CB  . ASP A 1 132 ? -12.116 -20.314 -14.330 1.00 7.81  ? 157 ASP A CB  1 
ATOM   997  C CG  . ASP A 1 132 ? -11.684 -19.437 -15.491 1.00 11.24 ? 157 ASP A CG  1 
ATOM   998  O OD1 . ASP A 1 132 ? -11.137 -19.954 -16.503 1.00 11.84 ? 157 ASP A OD1 1 
ATOM   999  O OD2 . ASP A 1 132 ? -11.857 -18.204 -15.373 1.00 11.00 ? 157 ASP A OD2 1 
ATOM   1000 N N   A GLU A 1 133 ? -11.558 -23.138 -16.446 0.54 8.64  ? 158 GLU A N   1 
ATOM   1001 N N   B GLU A 1 133 ? -11.552 -23.159 -16.437 0.46 8.68  ? 158 GLU A N   1 
ATOM   1002 C CA  A GLU A 1 133 ? -10.566 -24.010 -17.056 0.54 10.98 ? 158 GLU A CA  1 
ATOM   1003 C CA  B GLU A 1 133 ? -10.522 -24.004 -17.030 0.46 11.01 ? 158 GLU A CA  1 
ATOM   1004 C C   A GLU A 1 133 ? -9.714  -23.281 -18.087 0.54 10.24 ? 158 GLU A C   1 
ATOM   1005 C C   B GLU A 1 133 ? -9.679  -23.267 -18.061 0.46 10.24 ? 158 GLU A C   1 
ATOM   1006 O O   A GLU A 1 133 ? -8.854  -23.902 -18.725 0.54 12.33 ? 158 GLU A O   1 
ATOM   1007 O O   B GLU A 1 133 ? -8.795  -23.874 -18.679 0.46 12.28 ? 158 GLU A O   1 
ATOM   1008 C CB  A GLU A 1 133 ? -11.275 -25.207 -17.704 0.54 10.36 ? 158 GLU A CB  1 
ATOM   1009 C CB  B GLU A 1 133 ? -11.161 -25.237 -17.677 0.46 10.40 ? 158 GLU A CB  1 
ATOM   1010 C CG  A GLU A 1 133 ? -11.916 -26.177 -16.706 0.54 13.31 ? 158 GLU A CG  1 
ATOM   1011 C CG  B GLU A 1 133 ? -11.800 -26.204 -16.698 0.46 13.41 ? 158 GLU A CG  1 
ATOM   1012 C CD  A GLU A 1 133 ? -10.896 -26.977 -15.928 0.54 16.56 ? 158 GLU A CD  1 
ATOM   1013 C CD  B GLU A 1 133 ? -12.386 -27.411 -17.399 0.46 13.65 ? 158 GLU A CD  1 
ATOM   1014 O OE1 A GLU A 1 133 ? -9.917  -27.436 -16.544 0.54 15.67 ? 158 GLU A OE1 1 
ATOM   1015 O OE1 B GLU A 1 133 ? -11.630 -28.131 -18.085 0.46 22.30 ? 158 GLU A OE1 1 
ATOM   1016 O OE2 A GLU A 1 133 ? -11.066 -27.150 -14.699 0.54 22.78 ? 158 GLU A OE2 1 
ATOM   1017 O OE2 B GLU A 1 133 ? -13.606 -27.633 -17.269 0.46 21.66 ? 158 GLU A OE2 1 
ATOM   1018 N N   . THR A 1 134 ? -9.932  -21.978 -18.258 1.00 8.55  ? 159 THR A N   1 
ATOM   1019 C CA  . THR A 1 134 ? -9.306  -21.182 -19.306 1.00 9.59  ? 159 THR A CA  1 
ATOM   1020 C C   . THR A 1 134 ? -8.252  -20.219 -18.780 1.00 9.75  ? 159 THR A C   1 
ATOM   1021 O O   . THR A 1 134 ? -7.176  -20.105 -19.368 1.00 10.14 ? 159 THR A O   1 
ATOM   1022 C CB  . THR A 1 134 ? -10.405 -20.409 -20.046 1.00 10.50 ? 159 THR A CB  1 
ATOM   1023 O OG1 . THR A 1 134 ? -11.328 -21.348 -20.626 1.00 12.44 ? 159 THR A OG1 1 
ATOM   1024 C CG2 . THR A 1 134 ? -9.847  -19.483 -21.123 1.00 8.72  ? 159 THR A CG2 1 
ATOM   1025 N N   . PHE A 1 135 ? -8.556  -19.516 -17.690 1.00 9.10  ? 160 PHE A N   1 
ATOM   1026 C CA  . PHE A 1 135 ? -7.610  -18.609 -17.048 1.00 8.75  ? 160 PHE A CA  1 
ATOM   1027 C C   . PHE A 1 135 ? -6.258  -19.270 -16.802 1.00 8.82  ? 160 PHE A C   1 
ATOM   1028 O O   . PHE A 1 135 ? -6.187  -20.411 -16.336 1.00 10.19 ? 160 PHE A O   1 
ATOM   1029 C CB  . PHE A 1 135 ? -8.227  -18.156 -15.716 1.00 10.60 ? 160 PHE A CB  1 
ATOM   1030 C CG  . PHE A 1 135 ? -7.319  -17.306 -14.848 1.00 9.22  ? 160 PHE A CG  1 
ATOM   1031 C CD1 . PHE A 1 135 ? -6.335  -17.874 -14.055 1.00 8.13  ? 160 PHE A CD1 1 
ATOM   1032 C CD2 . PHE A 1 135 ? -7.498  -15.931 -14.806 1.00 9.70  ? 160 PHE A CD2 1 
ATOM   1033 C CE1 . PHE A 1 135 ? -5.517  -17.087 -13.248 1.00 8.91  ? 160 PHE A CE1 1 
ATOM   1034 C CE2 . PHE A 1 135 ? -6.707  -15.134 -13.988 1.00 8.42  ? 160 PHE A CE2 1 
ATOM   1035 C CZ  . PHE A 1 135 ? -5.707  -15.704 -13.223 1.00 8.07  ? 160 PHE A CZ  1 
ATOM   1036 N N   . ARG A 1 136 ? -5.177  -18.534 -17.067 1.00 8.37  ? 161 ARG A N   1 
ATOM   1037 C CA  . ARG A 1 136 ? -3.867  -18.961 -16.584 1.00 9.27  ? 161 ARG A CA  1 
ATOM   1038 C C   . ARG A 1 136 ? -3.059  -17.745 -16.167 1.00 7.35  ? 161 ARG A C   1 
ATOM   1039 O O   . ARG A 1 136 ? -3.015  -16.746 -16.892 1.00 9.57  ? 161 ARG A O   1 
ATOM   1040 C CB  . ARG A 1 136 ? -3.094  -19.771 -17.648 1.00 9.88  ? 161 ARG A CB  1 
ATOM   1041 C CG  . ARG A 1 136 ? -3.024  -19.123 -19.012 1.00 8.81  ? 161 ARG A CG  1 
ATOM   1042 C CD  . ARG A 1 136 ? -2.377  -20.051 -20.015 1.00 11.96 ? 161 ARG A CD  1 
ATOM   1043 N NE  . ARG A 1 136 ? -0.953  -20.207 -19.756 1.00 10.45 ? 161 ARG A NE  1 
ATOM   1044 C CZ  . ARG A 1 136 ? -0.147  -20.963 -20.487 1.00 12.95 ? 161 ARG A CZ  1 
ATOM   1045 N NH1 . ARG A 1 136 ? -0.600  -21.660 -21.521 1.00 13.86 ? 161 ARG A NH1 1 
ATOM   1046 N NH2 . ARG A 1 136 ? 1.146   -21.012 -20.180 1.00 14.16 ? 161 ARG A NH2 1 
ATOM   1047 N N   . LEU A 1 137 ? -2.447  -17.824 -14.988 1.00 8.92  ? 162 LEU A N   1 
ATOM   1048 C CA  . LEU A 1 137 ? -1.448  -16.861 -14.555 1.00 11.10 ? 162 LEU A CA  1 
ATOM   1049 C C   . LEU A 1 137 ? -0.116  -17.581 -14.526 1.00 11.20 ? 162 LEU A C   1 
ATOM   1050 O O   . LEU A 1 137 ? -0.002  -18.655 -13.924 1.00 10.76 ? 162 LEU A O   1 
ATOM   1051 C CB  . LEU A 1 137 ? -1.768  -16.274 -13.178 1.00 9.86  ? 162 LEU A CB  1 
ATOM   1052 C CG  . LEU A 1 137 ? -0.947  -15.010 -12.869 1.00 12.86 ? 162 LEU A CG  1 
ATOM   1053 C CD1 . LEU A 1 137 ? -1.349  -13.858 -13.786 1.00 12.77 ? 162 LEU A CD1 1 
ATOM   1054 C CD2 . LEU A 1 137 ? -1.106  -14.591 -11.407 1.00 13.03 ? 162 LEU A CD2 1 
ATOM   1055 N N   . ASP A 1 138 ? 0.863   -17.014 -15.212 1.00 10.12 ? 163 ASP A N   1 
ATOM   1056 C CA  . ASP A 1 138 ? 2.161   -17.624 -15.408 1.00 9.70  ? 163 ASP A CA  1 
ATOM   1057 C C   . ASP A 1 138 ? 3.304   -16.845 -14.806 1.00 11.08 ? 163 ASP A C   1 
ATOM   1058 O O   . ASP A 1 138 ? 4.331   -17.441 -14.463 1.00 14.32 ? 163 ASP A O   1 
ATOM   1059 C CB  . ASP A 1 138 ? 2.415   -17.793 -16.910 1.00 9.54  ? 163 ASP A CB  1 
ATOM   1060 C CG  . ASP A 1 138 ? 1.444   -18.742 -17.535 1.00 13.61 ? 163 ASP A CG  1 
ATOM   1061 O OD1 . ASP A 1 138 ? 1.773   -19.947 -17.547 1.00 13.78 ? 163 ASP A OD1 1 
ATOM   1062 O OD2 . ASP A 1 138 ? 0.368   -18.303 -17.995 1.00 10.03 ? 163 ASP A OD2 1 
ATOM   1063 N N   . ARG A 1 139 ? 3.168   -15.529 -14.692 1.00 10.85 ? 164 ARG A N   1 
ATOM   1064 C CA  . ARG A 1 139 ? 4.264   -14.680 -14.272 1.00 10.05 ? 164 ARG A CA  1 
ATOM   1065 C C   . ARG A 1 139 ? 3.788   -13.716 -13.199 1.00 10.47 ? 164 ARG A C   1 
ATOM   1066 O O   . ARG A 1 139 ? 2.589   -13.527 -12.978 1.00 12.31 ? 164 ARG A O   1 
ATOM   1067 C CB  . ARG A 1 139 ? 4.852   -13.905 -15.463 1.00 8.95  ? 164 ARG A CB  1 
ATOM   1068 C CG  . ARG A 1 139 ? 5.622   -14.822 -16.405 1.00 8.19  ? 164 ARG A CG  1 
ATOM   1069 C CD  . ARG A 1 139 ? 5.997   -14.120 -17.709 1.00 9.58  ? 164 ARG A CD  1 
ATOM   1070 N NE  . ARG A 1 139 ? 4.797   -13.864 -18.490 1.00 11.42 ? 164 ARG A NE  1 
ATOM   1071 C CZ  . ARG A 1 139 ? 4.748   -13.129 -19.591 1.00 10.99 ? 164 ARG A CZ  1 
ATOM   1072 N NH1 . ARG A 1 139 ? 5.846   -12.664 -20.163 1.00 13.15 ? 164 ARG A NH1 1 
ATOM   1073 N NH2 . ARG A 1 139 ? 3.565   -12.850 -20.127 1.00 11.39 ? 164 ARG A NH2 1 
ATOM   1074 N N   . THR A 1 140 ? 4.761   -13.118 -12.527 1.00 9.00  ? 165 THR A N   1 
ATOM   1075 C CA  . THR A 1 140 ? 4.520   -12.059 -11.565 1.00 9.07  ? 165 THR A CA  1 
ATOM   1076 C C   . THR A 1 140 ? 4.500   -10.697 -12.264 1.00 8.37  ? 165 THR A C   1 
ATOM   1077 O O   . THR A 1 140 ? 4.688   -10.576 -13.482 1.00 9.63  ? 165 THR A O   1 
ATOM   1078 C CB  . THR A 1 140 ? 5.603   -12.077 -10.490 1.00 9.03  ? 165 THR A CB  1 
ATOM   1079 O OG1 . THR A 1 140 ? 6.879   -11.895 -11.123 1.00 11.82 ? 165 THR A OG1 1 
ATOM   1080 C CG2 . THR A 1 140 ? 5.600   -13.398 -9.719  1.00 11.78 ? 165 THR A CG2 1 
ATOM   1081 N N   . GLU A 1 141 ? 4.263   -9.638  -11.465 1.00 9.67  ? 166 GLU A N   1 
ATOM   1082 C CA  . GLU A 1 141 ? 4.437   -8.270  -11.950 1.00 8.81  ? 166 GLU A CA  1 
ATOM   1083 C C   . GLU A 1 141 ? 5.922   -7.908  -11.961 1.00 8.61  ? 166 GLU A C   1 
ATOM   1084 O O   . GLU A 1 141 ? 6.635   -8.212  -11.007 1.00 10.88 ? 166 GLU A O   1 
ATOM   1085 C CB  . GLU A 1 141 ? 3.695   -7.283  -11.058 1.00 10.25 ? 166 GLU A CB  1 
ATOM   1086 C CG  . GLU A 1 141 ? 2.191   -7.447  -11.055 1.00 9.32  ? 166 GLU A CG  1 
ATOM   1087 C CD  . GLU A 1 141 ? 1.539   -6.933  -12.315 1.00 12.68 ? 166 GLU A CD  1 
ATOM   1088 O OE1 . GLU A 1 141 ? 2.244   -6.410  -13.195 1.00 14.04 ? 166 GLU A OE1 1 
ATOM   1089 O OE2 . GLU A 1 141 ? 0.289   -7.046  -12.428 1.00 15.30 ? 166 GLU A OE2 1 
ATOM   1090 N N   . PRO A 1 142 ? 6.407   -7.207  -13.001 1.00 9.08  ? 167 PRO A N   1 
ATOM   1091 C CA  . PRO A 1 142 ? 5.662   -6.607  -14.114 1.00 10.55 ? 167 PRO A CA  1 
ATOM   1092 C C   . PRO A 1 142 ? 5.621   -7.432  -15.394 1.00 15.08 ? 167 PRO A C   1 
ATOM   1093 O O   . PRO A 1 142 ? 4.979   -6.996  -16.352 1.00 11.45 ? 167 PRO A O   1 
ATOM   1094 C CB  . PRO A 1 142 ? 6.436   -5.302  -14.347 1.00 13.41 ? 167 PRO A CB  1 
ATOM   1095 C CG  . PRO A 1 142 ? 7.862   -5.731  -14.125 1.00 13.08 ? 167 PRO A CG  1 
ATOM   1096 C CD  . PRO A 1 142 ? 7.789   -6.688  -12.944 1.00 11.39 ? 167 PRO A CD  1 
ATOM   1097 N N   . THR A 1 143 ? 6.261   -8.603  -15.454 1.00 9.62  ? 168 THR A N   1 
ATOM   1098 C CA  . THR A 1 143 ? 6.393   -9.274  -16.744 1.00 11.28 ? 168 THR A CA  1 
ATOM   1099 C C   . THR A 1 143 ? 5.084   -9.892  -17.221 1.00 12.91 ? 168 THR A C   1 
ATOM   1100 O O   . THR A 1 143 ? 4.969   -10.182 -18.412 1.00 12.89 ? 168 THR A O   1 
ATOM   1101 C CB  . THR A 1 143 ? 7.505   -10.346 -16.737 1.00 10.37 ? 168 THR A CB  1 
ATOM   1102 O OG1 . THR A 1 143 ? 7.223   -11.370 -15.776 1.00 12.44 ? 168 THR A OG1 1 
ATOM   1103 C CG2 . THR A 1 143 ? 8.897   -9.736  -16.473 1.00 13.18 ? 168 THR A CG2 1 
ATOM   1104 N N   . LEU A 1 144 ? 4.081   -10.079 -16.351 1.00 8.56  ? 169 LEU A N   1 
ATOM   1105 C CA  . LEU A 1 144 ? 2.799   -10.582 -16.862 1.00 10.35 ? 169 LEU A CA  1 
ATOM   1106 C C   . LEU A 1 144 ? 2.128   -9.619  -17.842 1.00 10.96 ? 169 LEU A C   1 
ATOM   1107 O O   . LEU A 1 144 ? 1.141   -10.009 -18.484 1.00 14.28 ? 169 LEU A O   1 
ATOM   1108 C CB  . LEU A 1 144 ? 1.836   -10.920 -15.715 1.00 9.84  ? 169 LEU A CB  1 
ATOM   1109 C CG  . LEU A 1 144 ? 1.421   -9.820  -14.744 1.00 10.32 ? 169 LEU A CG  1 
ATOM   1110 C CD1 . LEU A 1 144 ? 0.189   -9.106  -15.261 1.00 13.34 ? 169 LEU A CD1 1 
ATOM   1111 C CD2 . LEU A 1 144 ? 1.116   -10.431 -13.391 1.00 13.52 ? 169 LEU A CD2 1 
ATOM   1112 N N   . ASN A 1 145 ? 2.642   -8.396  -17.997 1.00 10.67 ? 170 ASN A N   1 
ATOM   1113 C CA  . ASN A 1 145 ? 2.063   -7.396  -18.888 1.00 11.23 ? 170 ASN A CA  1 
ATOM   1114 C C   . ASN A 1 145 ? 2.709   -7.330  -20.269 1.00 10.92 ? 170 ASN A C   1 
ATOM   1115 O O   . ASN A 1 145 ? 2.424   -6.382  -21.014 1.00 10.60 ? 170 ASN A O   1 
ATOM   1116 C CB  . ASN A 1 145 ? 2.139   -6.014  -18.245 1.00 12.18 ? 170 ASN A CB  1 
ATOM   1117 C CG  . ASN A 1 145 ? 1.474   -5.976  -16.915 1.00 17.56 ? 170 ASN A CG  1 
ATOM   1118 O OD1 . ASN A 1 145 ? 0.259   -6.100  -16.835 1.00 15.42 ? 170 ASN A OD1 1 
ATOM   1119 N ND2 . ASN A 1 145 ? 2.259   -5.818  -15.849 1.00 16.42 ? 170 ASN A ND2 1 
ATOM   1120 N N   . THR A 1 146 ? 3.550   -8.302  -20.652 1.00 9.48  ? 171 THR A N   1 
ATOM   1121 C CA  . THR A 1 146 ? 4.253   -8.147  -21.929 1.00 10.13 ? 171 THR A CA  1 
ATOM   1122 C C   . THR A 1 146 ? 3.305   -8.229  -23.122 1.00 11.75 ? 171 THR A C   1 
ATOM   1123 O O   . THR A 1 146 ? 3.578   -7.619  -24.160 1.00 10.19 ? 171 THR A O   1 
ATOM   1124 C CB  . THR A 1 146 ? 5.373   -9.179  -22.096 1.00 12.72 ? 171 THR A CB  1 
ATOM   1125 O OG1 . THR A 1 146 ? 4.903   -10.503 -21.818 1.00 11.04 ? 171 THR A OG1 1 
ATOM   1126 C CG2 . THR A 1 146 ? 6.536   -8.854  -21.157 1.00 14.14 ? 171 THR A CG2 1 
ATOM   1127 N N   . ALA A 1 147 ? 2.203   -8.977  -23.005 1.00 9.72  ? 172 ALA A N   1 
ATOM   1128 C CA  . ALA A 1 147 ? 1.089   -8.903  -23.958 1.00 9.75  ? 172 ALA A CA  1 
ATOM   1129 C C   . ALA A 1 147 ? 1.526   -9.224  -25.392 1.00 15.69 ? 172 ALA A C   1 
ATOM   1130 O O   . ALA A 1 147 ? 1.024   -8.643  -26.362 1.00 12.43 ? 172 ALA A O   1 
ATOM   1131 C CB  . ALA A 1 147 ? 0.429   -7.528  -23.896 1.00 12.31 ? 172 ALA A CB  1 
ATOM   1132 N N   . ILE A 1 148 ? 2.452   -10.163 -25.530 1.00 12.84 ? 173 ILE A N   1 
ATOM   1133 C CA  . ILE A 1 148 ? 2.997   -10.473 -26.858 1.00 13.05 ? 173 ILE A CA  1 
ATOM   1134 C C   . ILE A 1 148 ? 1.961   -11.238 -27.673 1.00 15.44 ? 173 ILE A C   1 
ATOM   1135 O O   . ILE A 1 148 ? 1.400   -12.237 -27.182 1.00 13.13 ? 173 ILE A O   1 
ATOM   1136 C CB  . ILE A 1 148 ? 4.292   -11.265 -26.725 1.00 13.48 ? 173 ILE A CB  1 
ATOM   1137 C CG1 . ILE A 1 148 ? 5.300   -10.439 -25.928 1.00 15.86 ? 173 ILE A CG1 1 
ATOM   1138 C CG2 . ILE A 1 148 ? 4.835   -11.621 -28.110 1.00 17.37 ? 173 ILE A CG2 1 
ATOM   1139 C CD1 . ILE A 1 148 ? 6.449   -11.231 -25.377 1.00 19.53 ? 173 ILE A CD1 1 
ATOM   1140 N N   . PRO A 1 149 ? 1.689   -10.834 -28.913 1.00 14.93 ? 174 PRO A N   1 
ATOM   1141 C CA  . PRO A 1 149 ? 0.668   -11.525 -29.706 1.00 13.53 ? 174 PRO A CA  1 
ATOM   1142 C C   . PRO A 1 149 ? 1.020   -12.997 -29.875 1.00 14.59 ? 174 PRO A C   1 
ATOM   1143 O O   . PRO A 1 149 ? 2.166   -13.345 -30.171 1.00 17.22 ? 174 PRO A O   1 
ATOM   1144 C CB  . PRO A 1 149 ? 0.701   -10.778 -31.045 1.00 21.75 ? 174 PRO A CB  1 
ATOM   1145 C CG  . PRO A 1 149 ? 1.257   -9.416  -30.703 1.00 23.06 ? 174 PRO A CG  1 
ATOM   1146 C CD  . PRO A 1 149 ? 2.276   -9.688  -29.632 1.00 15.78 ? 174 PRO A CD  1 
ATOM   1147 N N   . GLY A 1 150 ? 0.025   -13.863 -29.659 1.00 13.92 ? 175 GLY A N   1 
ATOM   1148 C CA  . GLY A 1 150 ? 0.205   -15.304 -29.751 1.00 18.00 ? 175 GLY A CA  1 
ATOM   1149 C C   . GLY A 1 150 ? 0.745   -15.996 -28.511 1.00 19.97 ? 175 GLY A C   1 
ATOM   1150 O O   . GLY A 1 150 ? 0.751   -17.235 -28.467 1.00 18.36 ? 175 GLY A O   1 
ATOM   1151 N N   . ASP A 1 151 ? 1.215   -15.244 -27.520 1.00 14.54 ? 176 ASP A N   1 
ATOM   1152 C CA  . ASP A 1 151 ? 1.706   -15.799 -26.263 1.00 11.88 ? 176 ASP A CA  1 
ATOM   1153 C C   . ASP A 1 151 ? 0.526   -16.158 -25.362 1.00 12.27 ? 176 ASP A C   1 
ATOM   1154 O O   . ASP A 1 151 ? -0.247  -15.266 -24.996 1.00 13.43 ? 176 ASP A O   1 
ATOM   1155 C CB  . ASP A 1 151 ? 2.593   -14.750 -25.588 1.00 11.00 ? 176 ASP A CB  1 
ATOM   1156 C CG  . ASP A 1 151 ? 3.374   -15.279 -24.404 1.00 12.77 ? 176 ASP A CG  1 
ATOM   1157 O OD1 . ASP A 1 151 ? 3.091   -16.380 -23.901 1.00 13.20 ? 176 ASP A OD1 1 
ATOM   1158 O OD2 . ASP A 1 151 ? 4.258   -14.542 -23.931 1.00 12.78 ? 176 ASP A OD2 1 
ATOM   1159 N N   . PRO A 1 152 ? 0.348   -17.427 -24.978 1.00 12.33 ? 177 PRO A N   1 
ATOM   1160 C CA  . PRO A 1 152 ? -0.780  -17.775 -24.097 1.00 13.79 ? 177 PRO A CA  1 
ATOM   1161 C C   . PRO A 1 152 ? -0.560  -17.415 -22.642 1.00 11.29 ? 177 PRO A C   1 
ATOM   1162 O O   . PRO A 1 152 ? -1.514  -17.519 -21.852 1.00 10.55 ? 177 PRO A O   1 
ATOM   1163 C CB  . PRO A 1 152 ? -0.901  -19.297 -24.253 1.00 14.16 ? 177 PRO A CB  1 
ATOM   1164 C CG  . PRO A 1 152 ? 0.477   -19.749 -24.621 1.00 13.37 ? 177 PRO A CG  1 
ATOM   1165 C CD  . PRO A 1 152 ? 1.158   -18.604 -25.347 1.00 13.82 ? 177 PRO A CD  1 
ATOM   1166 N N   . ARG A 1 153 ? 0.652   -17.022 -22.254 1.00 9.69  ? 178 ARG A N   1 
ATOM   1167 C CA  . ARG A 1 153 ? 0.913   -16.753 -20.847 1.00 10.42 ? 178 ARG A CA  1 
ATOM   1168 C C   . ARG A 1 153 ? 0.072   -15.586 -20.345 1.00 8.04  ? 178 ARG A C   1 
ATOM   1169 O O   . ARG A 1 153 ? -0.065  -14.562 -21.013 1.00 8.80  ? 178 ARG A O   1 
ATOM   1170 C CB  . ARG A 1 153 ? 2.393   -16.464 -20.618 1.00 11.74 ? 178 ARG A CB  1 
ATOM   1171 C CG  . ARG A 1 153 ? 3.267   -17.722 -20.722 1.00 10.30 ? 178 ARG A CG  1 
ATOM   1172 C CD  . ARG A 1 153 ? 4.736   -17.409 -20.600 1.00 12.22 ? 178 ARG A CD  1 
ATOM   1173 N NE  . ARG A 1 153 ? 5.175   -16.421 -21.571 1.00 12.24 ? 178 ARG A NE  1 
ATOM   1174 C CZ  . ARG A 1 153 ? 6.383   -15.887 -21.585 1.00 11.80 ? 178 ARG A CZ  1 
ATOM   1175 N NH1 . ARG A 1 153 ? 7.270   -16.164 -20.646 1.00 14.73 ? 178 ARG A NH1 1 
ATOM   1176 N NH2 . ARG A 1 153 ? 6.707   -15.056 -22.568 1.00 13.56 ? 178 ARG A NH2 1 
ATOM   1177 N N   . ASP A 1 154 ? -0.488  -15.750 -19.145 1.00 8.18  ? 179 ASP A N   1 
ATOM   1178 C CA  . ASP A 1 154 ? -1.207  -14.668 -18.468 1.00 8.92  ? 179 ASP A CA  1 
ATOM   1179 C C   . ASP A 1 154 ? -2.386  -14.161 -19.299 1.00 10.07 ? 179 ASP A C   1 
ATOM   1180 O O   . ASP A 1 154 ? -2.642  -12.958 -19.395 1.00 10.10 ? 179 ASP A O   1 
ATOM   1181 C CB  . ASP A 1 154 ? -0.241  -13.532 -18.125 1.00 10.43 ? 179 ASP A CB  1 
ATOM   1182 C CG  . ASP A 1 154 ? 1.000   -14.041 -17.422 1.00 11.69 ? 179 ASP A CG  1 
ATOM   1183 O OD1 . ASP A 1 154 ? 0.869   -14.571 -16.302 1.00 12.21 ? 179 ASP A OD1 1 
ATOM   1184 O OD2 . ASP A 1 154 ? 2.102   -13.958 -18.003 1.00 12.37 ? 179 ASP A OD2 1 
ATOM   1185 N N   . THR A 1 155 ? -3.130  -15.089 -19.885 1.00 7.92  ? 180 THR A N   1 
ATOM   1186 C CA  . THR A 1 155 ? -4.280  -14.769 -20.714 1.00 8.28  ? 180 THR A CA  1 
ATOM   1187 C C   . THR A 1 155 ? -5.534  -15.473 -20.203 1.00 9.39  ? 180 THR A C   1 
ATOM   1188 O O   . THR A 1 155 ? -5.475  -16.451 -19.448 1.00 7.93  ? 180 THR A O   1 
ATOM   1189 C CB  . THR A 1 155 ? -4.073  -15.171 -22.187 1.00 8.87  ? 180 THR A CB  1 
ATOM   1190 O OG1 . THR A 1 155 ? -3.929  -16.592 -22.264 1.00 9.54  ? 180 THR A OG1 1 
ATOM   1191 C CG2 . THR A 1 155 ? -2.854  -14.489 -22.821 1.00 8.66  ? 180 THR A CG2 1 
ATOM   1192 N N   . THR A 1 156 ? -6.680  -14.958 -20.641 1.00 8.51  ? 181 THR A N   1 
ATOM   1193 C CA  . THR A 1 156 ? -7.935  -15.692 -20.582 1.00 7.35  ? 181 THR A CA  1 
ATOM   1194 C C   . THR A 1 156 ? -8.793  -15.255 -21.761 1.00 8.01  ? 181 THR A C   1 
ATOM   1195 O O   . THR A 1 156 ? -8.369  -14.442 -22.593 1.00 10.18 ? 181 THR A O   1 
ATOM   1196 C CB  . THR A 1 156 ? -8.636  -15.478 -19.242 1.00 10.14 ? 181 THR A CB  1 
ATOM   1197 O OG1 . THR A 1 156 ? -9.684  -16.449 -19.097 1.00 11.00 ? 181 THR A OG1 1 
ATOM   1198 C CG2 . THR A 1 156 ? -9.212  -14.081 -19.167 1.00 10.63 ? 181 THR A CG2 1 
ATOM   1199 N N   . THR A 1 157 ? -9.999  -15.820 -21.852 1.00 8.73  ? 182 THR A N   1 
ATOM   1200 C CA  . THR A 1 157 ? -10.926 -15.378 -22.882 1.00 6.99  ? 182 THR A CA  1 
ATOM   1201 C C   . THR A 1 157 ? -11.996 -14.505 -22.264 1.00 8.72  ? 182 THR A C   1 
ATOM   1202 O O   . THR A 1 157 ? -12.282 -14.614 -21.070 1.00 9.30  ? 182 THR A O   1 
ATOM   1203 C CB  . THR A 1 157 ? -11.586 -16.570 -23.580 1.00 7.43  ? 182 THR A CB  1 
ATOM   1204 O OG1 . THR A 1 157 ? -12.433 -17.252 -22.647 1.00 9.54  ? 182 THR A OG1 1 
ATOM   1205 C CG2 . THR A 1 157 ? -10.528 -17.530 -24.120 1.00 10.03 ? 182 THR A CG2 1 
ATOM   1206 N N   . PRO A 1 158 ? -12.606 -13.611 -23.042 1.00 6.34  ? 183 PRO A N   1 
ATOM   1207 C CA  . PRO A 1 158 ? -13.697 -12.799 -22.473 1.00 8.72  ? 183 PRO A CA  1 
ATOM   1208 C C   . PRO A 1 158 ? -14.829 -13.636 -21.916 1.00 8.82  ? 183 PRO A C   1 
ATOM   1209 O O   . PRO A 1 158 ? -15.376 -13.310 -20.854 1.00 9.35  ? 183 PRO A O   1 
ATOM   1210 C CB  . PRO A 1 158 ? -14.151 -11.947 -23.664 1.00 8.74  ? 183 PRO A CB  1 
ATOM   1211 C CG  . PRO A 1 158 ? -12.910 -11.816 -24.500 1.00 8.90  ? 183 PRO A CG  1 
ATOM   1212 C CD  . PRO A 1 158 ? -12.209 -13.153 -24.384 1.00 8.54  ? 183 PRO A CD  1 
ATOM   1213 N N   . ARG A 1 159 ? -15.209 -14.703 -22.618 1.00 8.14  ? 184 ARG A N   1 
ATOM   1214 C CA  . ARG A 1 159 ? -16.297 -15.556 -22.150 1.00 7.25  ? 184 ARG A CA  1 
ATOM   1215 C C   . ARG A 1 159 ? -15.978 -16.150 -20.789 1.00 8.76  ? 184 ARG A C   1 
ATOM   1216 O O   . ARG A 1 159 ? -16.811 -16.123 -19.870 1.00 9.04  ? 184 ARG A O   1 
ATOM   1217 C CB  . ARG A 1 159 ? -16.561 -16.680 -23.158 1.00 8.25  ? 184 ARG A CB  1 
ATOM   1218 C CG  . ARG A 1 159 ? -17.804 -17.522 -22.825 1.00 7.99  ? 184 ARG A CG  1 
ATOM   1219 C CD  . ARG A 1 159 ? -17.791 -18.875 -23.554 1.00 8.27  ? 184 ARG A CD  1 
ATOM   1220 N NE  . ARG A 1 159 ? -17.789 -18.729 -25.002 1.00 10.07 ? 184 ARG A NE  1 
ATOM   1221 C CZ  . ARG A 1 159 ? -18.874 -18.590 -25.750 1.00 10.99 ? 184 ARG A CZ  1 
ATOM   1222 N NH1 . ARG A 1 159 ? -20.088 -18.556 -25.214 1.00 13.75 ? 184 ARG A NH1 1 
ATOM   1223 N NH2 . ARG A 1 159 ? -18.739 -18.484 -27.072 1.00 11.63 ? 184 ARG A NH2 1 
ATOM   1224 N N   . ALA A 1 160 ? -14.771 -16.690 -20.639 1.00 9.54  ? 185 ALA A N   1 
ATOM   1225 C CA  . ALA A 1 160 ? -14.411 -17.319 -19.379 1.00 11.28 ? 185 ALA A CA  1 
ATOM   1226 C C   . ALA A 1 160 ? -14.332 -16.298 -18.260 1.00 7.15  ? 185 ALA A C   1 
ATOM   1227 O O   . ALA A 1 160 ? -14.763 -16.577 -17.131 1.00 9.40  ? 185 ALA A O   1 
ATOM   1228 C CB  . ALA A 1 160 ? -13.080 -18.053 -19.516 1.00 9.91  ? 185 ALA A CB  1 
ATOM   1229 N N   A MET A 1 161 ? -13.765 -15.119 -18.538 0.61 7.84  ? 186 MET A N   1 
ATOM   1230 N N   B MET A 1 161 ? -13.776 -15.115 -18.538 0.39 7.85  ? 186 MET A N   1 
ATOM   1231 C CA  A MET A 1 161 ? -13.622 -14.124 -17.479 0.61 8.91  ? 186 MET A CA  1 
ATOM   1232 C CA  B MET A 1 161 ? -13.620 -14.129 -17.472 0.39 8.92  ? 186 MET A CA  1 
ATOM   1233 C C   A MET A 1 161 ? -14.976 -13.587 -17.037 0.61 9.10  ? 186 MET A C   1 
ATOM   1234 C C   B MET A 1 161 ? -14.966 -13.563 -17.040 0.39 9.07  ? 186 MET A C   1 
ATOM   1235 O O   A MET A 1 161 ? -15.192 -13.337 -15.842 0.61 8.30  ? 186 MET A O   1 
ATOM   1236 O O   B MET A 1 161 ? -15.171 -13.275 -15.853 0.39 8.33  ? 186 MET A O   1 
ATOM   1237 C CB  A MET A 1 161 ? -12.723 -12.975 -17.926 0.61 7.95  ? 186 MET A CB  1 
ATOM   1238 C CB  B MET A 1 161 ? -12.680 -13.004 -17.904 0.39 8.01  ? 186 MET A CB  1 
ATOM   1239 C CG  A MET A 1 161 ? -12.288 -12.074 -16.759 0.61 9.87  ? 186 MET A CG  1 
ATOM   1240 C CG  B MET A 1 161 ? -12.218 -12.131 -16.729 0.39 9.95  ? 186 MET A CG  1 
ATOM   1241 S SD  A MET A 1 161 ? -11.515 -12.959 -15.371 0.61 11.23 ? 186 MET A SD  1 
ATOM   1242 S SD  B MET A 1 161 ? -11.249 -13.030 -15.485 0.39 10.67 ? 186 MET A SD  1 
ATOM   1243 C CE  A MET A 1 161 ? -9.820  -12.415 -15.579 0.61 14.17 ? 186 MET A CE  1 
ATOM   1244 C CE  B MET A 1 161 ? -12.341 -12.954 -14.065 0.39 11.07 ? 186 MET A CE  1 
ATOM   1245 N N   . ALA A 1 162 ? -15.905 -13.405 -17.980 1.00 7.66  ? 187 ALA A N   1 
ATOM   1246 C CA  . ALA A 1 162 ? -17.229 -12.919 -17.604 1.00 7.84  ? 187 ALA A CA  1 
ATOM   1247 C C   . ALA A 1 162 ? -17.956 -13.941 -16.737 1.00 6.83  ? 187 ALA A C   1 
ATOM   1248 O O   . ALA A 1 162 ? -18.575 -13.581 -15.731 1.00 8.75  ? 187 ALA A O   1 
ATOM   1249 C CB  . ALA A 1 162 ? -18.064 -12.586 -18.839 1.00 9.06  ? 187 ALA A CB  1 
ATOM   1250 N N   . GLN A 1 163 ? -17.878 -15.221 -17.110 1.00 8.53  ? 188 GLN A N   1 
ATOM   1251 C CA  . GLN A 1 163 ? -18.485 -16.279 -16.312 1.00 8.13  ? 188 GLN A CA  1 
ATOM   1252 C C   . GLN A 1 163 ? -17.889 -16.333 -14.913 1.00 8.57  ? 188 GLN A C   1 
ATOM   1253 O O   . GLN A 1 163 ? -18.620 -16.421 -13.915 1.00 9.50  ? 188 GLN A O   1 
ATOM   1254 C CB  . GLN A 1 163 ? -18.298 -17.612 -17.032 1.00 8.18  ? 188 GLN A CB  1 
ATOM   1255 C CG  . GLN A 1 163 ? -18.781 -18.794 -16.259 1.00 13.19 ? 188 GLN A CG  1 
ATOM   1256 C CD  . GLN A 1 163 ? -20.245 -18.684 -15.928 1.00 15.20 ? 188 GLN A CD  1 
ATOM   1257 O OE1 . GLN A 1 163 ? -21.009 -18.010 -16.630 1.00 21.17 ? 188 GLN A OE1 1 
ATOM   1258 N NE2 . GLN A 1 163 ? -20.653 -19.341 -14.853 1.00 25.70 ? 188 GLN A NE2 1 
ATOM   1259 N N   . THR A 1 164 ? -16.566 -16.238 -14.816 1.00 8.59  ? 189 THR A N   1 
ATOM   1260 C CA  . THR A 1 164 ? -15.921 -16.255 -13.503 1.00 7.26  ? 189 THR A CA  1 
ATOM   1261 C C   . THR A 1 164 ? -16.287 -15.019 -12.690 1.00 6.55  ? 189 THR A C   1 
ATOM   1262 O O   . THR A 1 164 ? -16.536 -15.115 -11.480 1.00 9.46  ? 189 THR A O   1 
ATOM   1263 C CB  . THR A 1 164 ? -14.411 -16.365 -13.680 1.00 11.91 ? 189 THR A CB  1 
ATOM   1264 O OG1 . THR A 1 164 ? -14.102 -17.694 -14.116 1.00 11.74 ? 189 THR A OG1 1 
ATOM   1265 C CG2 . THR A 1 164 ? -13.702 -16.082 -12.359 1.00 18.42 ? 189 THR A CG2 1 
ATOM   1266 N N   . LEU A 1 165 ? -16.327 -13.845 -13.322 1.00 8.03  ? 190 LEU A N   1 
ATOM   1267 C CA  . LEU A 1 165 ? -16.663 -12.657 -12.546 1.00 6.97  ? 190 LEU A CA  1 
ATOM   1268 C C   . LEU A 1 165 ? -18.100 -12.738 -12.046 1.00 9.27  ? 190 LEU A C   1 
ATOM   1269 O O   . LEU A 1 165 ? -18.393 -12.327 -10.912 1.00 7.39  ? 190 LEU A O   1 
ATOM   1270 C CB  . LEU A 1 165 ? -16.438 -11.401 -13.386 1.00 8.73  ? 190 LEU A CB  1 
ATOM   1271 C CG  . LEU A 1 165 ? -16.589 -10.069 -12.638 1.00 8.92  ? 190 LEU A CG  1 
ATOM   1272 C CD1 . LEU A 1 165 ? -15.563 -9.943  -11.493 1.00 10.89 ? 190 LEU A CD1 1 
ATOM   1273 C CD2 . LEU A 1 165 ? -16.450 -8.893  -13.616 1.00 9.53  ? 190 LEU A CD2 1 
ATOM   1274 N N   . ARG A 1 166 ? -18.993 -13.322 -12.844 1.00 8.24  ? 191 ARG A N   1 
ATOM   1275 C CA  . ARG A 1 166 ? -20.352 -13.550 -12.362 1.00 6.67  ? 191 ARG A CA  1 
ATOM   1276 C C   . ARG A 1 166 ? -20.350 -14.474 -11.150 1.00 9.73  ? 191 ARG A C   1 
ATOM   1277 O O   . ARG A 1 166 ? -20.980 -14.174 -10.135 1.00 9.68  ? 191 ARG A O   1 
ATOM   1278 C CB  . ARG A 1 166 ? -21.227 -14.124 -13.473 1.00 9.40  ? 191 ARG A CB  1 
ATOM   1279 C CG  . ARG A 1 166 ? -22.671 -14.344 -12.998 1.00 11.33 ? 191 ARG A CG  1 
ATOM   1280 C CD  . ARG A 1 166 ? -23.490 -15.227 -13.907 1.00 15.30 ? 191 ARG A CD  1 
ATOM   1281 N NE  . ARG A 1 166 ? -24.888 -15.220 -13.484 1.00 13.36 ? 191 ARG A NE  1 
ATOM   1282 C CZ  . ARG A 1 166 ? -25.918 -15.488 -14.272 1.00 16.30 ? 191 ARG A CZ  1 
ATOM   1283 N NH1 . ARG A 1 166 ? -25.750 -15.832 -15.537 1.00 19.45 ? 191 ARG A NH1 1 
ATOM   1284 N NH2 . ARG A 1 166 ? -27.150 -15.416 -13.773 1.00 19.13 ? 191 ARG A NH2 1 
ATOM   1285 N N   . GLN A 1 167 ? -19.620 -15.592 -11.223 1.00 8.40  ? 192 GLN A N   1 
ATOM   1286 C CA  . GLN A 1 167 ? -19.622 -16.527 -10.101 1.00 10.26 ? 192 GLN A CA  1 
ATOM   1287 C C   . GLN A 1 167 ? -19.023 -15.892 -8.853  1.00 9.88  ? 192 GLN A C   1 
ATOM   1288 O O   . GLN A 1 167 ? -19.482 -16.152 -7.737  1.00 9.37  ? 192 GLN A O   1 
ATOM   1289 C CB  . GLN A 1 167 ? -18.864 -17.802 -10.474 1.00 12.64 ? 192 GLN A CB  1 
ATOM   1290 C CG  . GLN A 1 167 ? -19.495 -18.581 -11.625 1.00 14.14 ? 192 GLN A CG  1 
ATOM   1291 C CD  . GLN A 1 167 ? -20.880 -19.091 -11.289 1.00 32.14 ? 192 GLN A CD  1 
ATOM   1292 O OE1 . GLN A 1 167 ? -21.886 -18.487 -11.667 1.00 41.48 ? 192 GLN A OE1 1 
ATOM   1293 N NE2 . GLN A 1 167 ? -20.943 -20.208 -10.575 1.00 44.17 ? 192 GLN A NE2 1 
ATOM   1294 N N   . LEU A 1 168 ? -18.005 -15.039 -9.021  1.00 8.91  ? 193 LEU A N   1 
ATOM   1295 C CA  . LEU A 1 168 ? -17.336 -14.431 -7.872  1.00 9.35  ? 193 LEU A CA  1 
ATOM   1296 C C   . LEU A 1 168 ? -18.199 -13.360 -7.216  1.00 9.28  ? 193 LEU A C   1 
ATOM   1297 O O   . LEU A 1 168 ? -18.222 -13.248 -5.986  1.00 12.33 ? 193 LEU A O   1 
ATOM   1298 C CB  . LEU A 1 168 ? -16.002 -13.824 -8.291  1.00 7.64  ? 193 LEU A CB  1 
ATOM   1299 C CG  . LEU A 1 168 ? -14.884 -14.809 -8.648  1.00 7.84  ? 193 LEU A CG  1 
ATOM   1300 C CD1 . LEU A 1 168 ? -13.675 -14.054 -9.195  1.00 11.43 ? 193 LEU A CD1 1 
ATOM   1301 C CD2 . LEU A 1 168 ? -14.519 -15.627 -7.422  1.00 8.60  ? 193 LEU A CD2 1 
ATOM   1302 N N   . THR A 1 169 ? -18.884 -12.542 -8.013  1.00 8.48  ? 194 THR A N   1 
ATOM   1303 C CA  . THR A 1 169 ? -19.541 -11.351 -7.474  1.00 10.30 ? 194 THR A CA  1 
ATOM   1304 C C   . THR A 1 169 ? -21.040 -11.511 -7.278  1.00 10.30 ? 194 THR A C   1 
ATOM   1305 O O   . THR A 1 169 ? -21.614 -10.785 -6.459  1.00 13.00 ? 194 THR A O   1 
ATOM   1306 C CB  . THR A 1 169 ? -19.320 -10.133 -8.382  1.00 8.31  ? 194 THR A CB  1 
ATOM   1307 O OG1 . THR A 1 169 ? -19.872 -10.383 -9.686  1.00 11.43 ? 194 THR A OG1 1 
ATOM   1308 C CG2 . THR A 1 169 ? -17.832 -9.787  -8.485  1.00 10.97 ? 194 THR A CG2 1 
ATOM   1309 N N   . LEU A 1 170 ? -21.684 -12.426 -8.011  1.00 10.27 ? 195 LEU A N   1 
ATOM   1310 C CA  . LEU A 1 170 ? -23.127 -12.601 -7.960  1.00 8.73  ? 195 LEU A CA  1 
ATOM   1311 C C   . LEU A 1 170 ? -23.545 -14.019 -7.626  1.00 10.52 ? 195 LEU A C   1 
ATOM   1312 O O   . LEU A 1 170 ? -24.686 -14.224 -7.201  1.00 13.44 ? 195 LEU A O   1 
ATOM   1313 C CB  . LEU A 1 170 ? -23.761 -12.207 -9.304  1.00 11.22 ? 195 LEU A CB  1 
ATOM   1314 C CG  . LEU A 1 170 ? -23.470 -10.780 -9.767  1.00 9.20  ? 195 LEU A CG  1 
ATOM   1315 C CD1 . LEU A 1 170 ? -23.985 -10.586 -11.173 1.00 12.95 ? 195 LEU A CD1 1 
ATOM   1316 C CD2 . LEU A 1 170 ? -24.089 -9.778  -8.802  1.00 11.59 ? 195 LEU A CD2 1 
ATOM   1317 N N   . GLY A 1 171 ? -22.668 -14.991 -7.802  1.00 9.84  ? 196 GLY A N   1 
ATOM   1318 C CA  . GLY A 1 171 ? -22.948 -16.373 -7.483  1.00 8.81  ? 196 GLY A CA  1 
ATOM   1319 C C   . GLY A 1 171 ? -22.279 -16.772 -6.191  1.00 10.14 ? 196 GLY A C   1 
ATOM   1320 O O   . GLY A 1 171 ? -22.151 -15.970 -5.258  1.00 10.09 ? 196 GLY A O   1 
ATOM   1321 N N   . HIS A 1 172 ? -21.842 -18.027 -6.128  1.00 9.02  ? 197 HIS A N   1 
ATOM   1322 C CA  . HIS A 1 172 ? -21.441 -18.604 -4.853  1.00 8.69  ? 197 HIS A CA  1 
ATOM   1323 C C   . HIS A 1 172 ? -20.071 -19.270 -4.916  1.00 10.62 ? 197 HIS A C   1 
ATOM   1324 O O   . HIS A 1 172 ? -19.796 -20.218 -4.179  1.00 12.31 ? 197 HIS A O   1 
ATOM   1325 C CB  . HIS A 1 172 ? -22.530 -19.548 -4.349  1.00 9.60  ? 197 HIS A CB  1 
ATOM   1326 C CG  . HIS A 1 172 ? -23.752 -18.801 -3.923  1.00 11.58 ? 197 HIS A CG  1 
ATOM   1327 N ND1 . HIS A 1 172 ? -23.813 -18.132 -2.721  1.00 14.32 ? 197 HIS A ND1 1 
ATOM   1328 C CD2 . HIS A 1 172 ? -24.907 -18.519 -4.570  1.00 15.84 ? 197 HIS A CD2 1 
ATOM   1329 C CE1 . HIS A 1 172 ? -24.972 -17.504 -2.626  1.00 24.24 ? 197 HIS A CE1 1 
ATOM   1330 N NE2 . HIS A 1 172 ? -25.651 -17.719 -3.737  1.00 16.49 ? 197 HIS A NE2 1 
ATOM   1331 N N   . ALA A 1 173 ? -19.187 -18.755 -5.768  1.00 9.34  ? 198 ALA A N   1 
ATOM   1332 C CA  . ALA A 1 173 ? -17.801 -19.204 -5.751  1.00 8.74  ? 198 ALA A CA  1 
ATOM   1333 C C   . ALA A 1 173 ? -17.119 -18.841 -4.443  1.00 9.90  ? 198 ALA A C   1 
ATOM   1334 O O   . ALA A 1 173 ? -16.201 -19.549 -4.018  1.00 10.75 ? 198 ALA A O   1 
ATOM   1335 C CB  . ALA A 1 173 ? -17.022 -18.598 -6.921  1.00 10.34 ? 198 ALA A CB  1 
ATOM   1336 N N   . LEU A 1 174 ? -17.526 -17.729 -3.822  1.00 7.99  ? 199 LEU A N   1 
ATOM   1337 C CA  . LEU A 1 174 ? -17.045 -17.266 -2.528  1.00 7.85  ? 199 LEU A CA  1 
ATOM   1338 C C   . LEU A 1 174 ? -18.157 -17.376 -1.494  1.00 8.31  ? 199 LEU A C   1 
ATOM   1339 O O   . LEU A 1 174 ? -19.342 -17.386 -1.835  1.00 10.35 ? 199 LEU A O   1 
ATOM   1340 C CB  . LEU A 1 174 ? -16.574 -15.807 -2.602  1.00 9.31  ? 199 LEU A CB  1 
ATOM   1341 C CG  . LEU A 1 174 ? -15.388 -15.577 -3.541  1.00 7.84  ? 199 LEU A CG  1 
ATOM   1342 C CD1 . LEU A 1 174 ? -15.106 -14.080 -3.633  1.00 11.34 ? 199 LEU A CD1 1 
ATOM   1343 C CD2 . LEU A 1 174 ? -14.157 -16.304 -3.030  1.00 12.10 ? 199 LEU A CD2 1 
ATOM   1344 N N   . GLY A 1 175 ? -17.756 -17.423 -0.219  1.00 8.60  ? 200 GLY A N   1 
ATOM   1345 C CA  . GLY A 1 175 ? -18.717 -17.295 0.867   1.00 8.51  ? 200 GLY A CA  1 
ATOM   1346 C C   . GLY A 1 175 ? -19.353 -15.920 0.891   1.00 9.75  ? 200 GLY A C   1 
ATOM   1347 O O   . GLY A 1 175 ? -18.829 -14.971 0.326   1.00 9.96  ? 200 GLY A O   1 
ATOM   1348 N N   . GLU A 1 176 ? -20.497 -15.808 1.580   1.00 9.05  ? 201 GLU A N   1 
ATOM   1349 C CA  . GLU A 1 176 ? -21.301 -14.588 1.505   1.00 15.43 ? 201 GLU A CA  1 
ATOM   1350 C C   . GLU A 1 176 ? -20.507 -13.345 1.905   1.00 9.67  ? 201 GLU A C   1 
ATOM   1351 O O   . GLU A 1 176 ? -20.523 -12.332 1.189   1.00 10.85 ? 201 GLU A O   1 
ATOM   1352 C CB  . GLU A 1 176 ? -22.558 -14.730 2.372   1.00 14.23 ? 201 GLU A CB  1 
ATOM   1353 C CG  . GLU A 1 176 ? -23.540 -13.574 2.215   1.00 23.68 ? 201 GLU A CG  1 
ATOM   1354 C CD  . GLU A 1 176 ? -24.825 -13.784 3.000   1.00 44.75 ? 201 GLU A CD  1 
ATOM   1355 O OE1 . GLU A 1 176 ? -25.880 -14.020 2.370   1.00 55.56 ? 201 GLU A OE1 1 
ATOM   1356 O OE2 . GLU A 1 176 ? -24.780 -13.711 4.247   1.00 51.63 ? 201 GLU A OE2 1 
ATOM   1357 N N   . THR A 1 177 ? -19.813 -13.391 3.044   1.00 9.50  ? 202 THR A N   1 
ATOM   1358 C CA  . THR A 1 177 ? -19.045 -12.226 3.486   1.00 12.00 ? 202 THR A CA  1 
ATOM   1359 C C   . THR A 1 177 ? -17.932 -11.898 2.496   1.00 8.39  ? 202 THR A C   1 
ATOM   1360 O O   . THR A 1 177 ? -17.649 -10.721 2.221   1.00 9.43  ? 202 THR A O   1 
ATOM   1361 C CB  . THR A 1 177 ? -18.468 -12.501 4.877   1.00 12.35 ? 202 THR A CB  1 
ATOM   1362 O OG1 . THR A 1 177 ? -19.552 -12.650 5.800   1.00 16.73 ? 202 THR A OG1 1 
ATOM   1363 C CG2 . THR A 1 177 ? -17.572 -11.356 5.345   1.00 16.30 ? 202 THR A CG2 1 
ATOM   1364 N N   . GLN A 1 178 ? -17.329 -12.929 1.910   1.00 9.62  ? 203 GLN A N   1 
ATOM   1365 C CA  . GLN A 1 178 ? -16.193 -12.717 1.024   1.00 8.95  ? 203 GLN A CA  1 
ATOM   1366 C C   . GLN A 1 178 ? -16.655 -12.150 -0.308  1.00 8.64  ? 203 GLN A C   1 
ATOM   1367 O O   . GLN A 1 178 ? -16.002 -11.260 -0.865  1.00 7.89  ? 203 GLN A O   1 
ATOM   1368 C CB  . GLN A 1 178 ? -15.451 -14.038 0.840   1.00 7.77  ? 203 GLN A CB  1 
ATOM   1369 C CG  . GLN A 1 178 ? -14.719 -14.522 2.092   1.00 11.06 ? 203 GLN A CG  1 
ATOM   1370 C CD  . GLN A 1 178 ? -15.644 -15.130 3.143   1.00 10.28 ? 203 GLN A CD  1 
ATOM   1371 O OE1 . GLN A 1 178 ? -16.733 -15.649 2.830   1.00 9.14  ? 203 GLN A OE1 1 
ATOM   1372 N NE2 . GLN A 1 178 ? -15.229 -15.033 4.408   1.00 12.67 ? 203 GLN A NE2 1 
ATOM   1373 N N   . ARG A 1 179 ? -17.799 -12.628 -0.813  1.00 9.48  ? 204 ARG A N   1 
ATOM   1374 C CA  . ARG A 1 179 ? -18.383 -12.049 -2.015  1.00 7.25  ? 204 ARG A CA  1 
ATOM   1375 C C   . ARG A 1 179 ? -18.673 -10.574 -1.799  1.00 7.99  ? 204 ARG A C   1 
ATOM   1376 O O   . ARG A 1 179 ? -18.370 -9.737  -2.654  1.00 8.12  ? 204 ARG A O   1 
ATOM   1377 C CB  . ARG A 1 179 ? -19.664 -12.803 -2.388  1.00 8.99  ? 204 ARG A CB  1 
ATOM   1378 C CG  . ARG A 1 179 ? -20.381 -12.260 -3.608  1.00 8.95  ? 204 ARG A CG  1 
ATOM   1379 C CD  . ARG A 1 179 ? -21.634 -13.054 -3.912  1.00 12.51 ? 204 ARG A CD  1 
ATOM   1380 N NE  . ARG A 1 179 ? -22.697 -12.826 -2.936  1.00 16.28 ? 204 ARG A NE  1 
ATOM   1381 C CZ  . ARG A 1 179 ? -23.928 -13.322 -3.039  1.00 16.52 ? 204 ARG A CZ  1 
ATOM   1382 N NH1 . ARG A 1 179 ? -24.264 -14.148 -4.020  1.00 15.92 ? 204 ARG A NH1 1 
ATOM   1383 N NH2 . ARG A 1 179 ? -24.842 -12.982 -2.134  1.00 21.04 ? 204 ARG A NH2 1 
ATOM   1384 N N   . ALA A 1 180 ? -19.301 -10.242 -0.667  1.00 9.72  ? 205 ALA A N   1 
ATOM   1385 C CA  . ALA A 1 180 ? -19.597 -8.848  -0.376  1.00 8.71  ? 205 ALA A CA  1 
ATOM   1386 C C   . ALA A 1 180 ? -18.325 -8.013  -0.296  1.00 10.58 ? 205 ALA A C   1 
ATOM   1387 O O   . ALA A 1 180 ? -18.302 -6.859  -0.740  1.00 10.57 ? 205 ALA A O   1 
ATOM   1388 C CB  . ALA A 1 180 ? -20.392 -8.750  0.928   1.00 8.98  ? 205 ALA A CB  1 
ATOM   1389 N N   . GLN A 1 181 ? -17.264 -8.569  0.282   1.00 7.89  ? 206 GLN A N   1 
ATOM   1390 C CA  . GLN A 1 181 ? -16.004 -7.833  0.369   1.00 7.69  ? 206 GLN A CA  1 
ATOM   1391 C C   . GLN A 1 181 ? -15.417 -7.569  -1.013  1.00 8.43  ? 206 GLN A C   1 
ATOM   1392 O O   . GLN A 1 181 ? -14.966 -6.449  -1.304  1.00 9.21  ? 206 GLN A O   1 
ATOM   1393 C CB  . GLN A 1 181 ? -15.013 -8.587  1.250   1.00 8.74  ? 206 GLN A CB  1 
ATOM   1394 C CG  . GLN A 1 181 ? -13.663 -7.875  1.399   1.00 10.47 ? 206 GLN A CG  1 
ATOM   1395 C CD  . GLN A 1 181 ? -13.759 -6.564  2.147   1.00 13.18 ? 206 GLN A CD  1 
ATOM   1396 O OE1 . GLN A 1 181 ? -13.677 -6.542  3.373   1.00 14.97 ? 206 GLN A OE1 1 
ATOM   1397 N NE2 . GLN A 1 181 ? -13.890 -5.457  1.415   1.00 11.31 ? 206 GLN A NE2 1 
ATOM   1398 N N   . LEU A 1 182 ? -15.434 -8.578  -1.886  1.00 9.55  ? 207 LEU A N   1 
ATOM   1399 C CA  . LEU A 1 182 ? -14.954 -8.375  -3.248  1.00 8.92  ? 207 LEU A CA  1 
ATOM   1400 C C   . LEU A 1 182 ? -15.756 -7.294  -3.952  1.00 9.63  ? 207 LEU A C   1 
ATOM   1401 O O   . LEU A 1 182 ? -15.184 -6.415  -4.615  1.00 8.72  ? 207 LEU A O   1 
ATOM   1402 C CB  . LEU A 1 182 ? -15.029 -9.687  -4.028  1.00 7.16  ? 207 LEU A CB  1 
ATOM   1403 C CG  . LEU A 1 182 ? -14.541 -9.583  -5.475  1.00 6.84  ? 207 LEU A CG  1 
ATOM   1404 C CD1 . LEU A 1 182 ? -13.090 -9.105  -5.513  1.00 10.37 ? 207 LEU A CD1 1 
ATOM   1405 C CD2 . LEU A 1 182 ? -14.671 -10.923 -6.190  1.00 9.69  ? 207 LEU A CD2 1 
ATOM   1406 N N   . VAL A 1 183 ? -17.081 -7.345  -3.820  1.00 7.89  ? 208 VAL A N   1 
ATOM   1407 C CA  . VAL A 1 183 ? -17.943 -6.358  -4.466  1.00 9.09  ? 208 VAL A CA  1 
ATOM   1408 C C   . VAL A 1 183 ? -17.660 -4.966  -3.916  1.00 7.96  ? 208 VAL A C   1 
ATOM   1409 O O   . VAL A 1 183 ? -17.603 -3.988  -4.670  1.00 9.13  ? 208 VAL A O   1 
ATOM   1410 C CB  . VAL A 1 183 ? -19.428 -6.747  -4.300  1.00 7.81  ? 208 VAL A CB  1 
ATOM   1411 C CG1 . VAL A 1 183 ? -20.328 -5.563  -4.653  1.00 14.96 ? 208 VAL A CG1 1 
ATOM   1412 C CG2 . VAL A 1 183 ? -19.775 -7.959  -5.180  1.00 10.01 ? 208 VAL A CG2 1 
ATOM   1413 N N   . THR A 1 184 ? -17.497 -4.853  -2.594  1.00 7.85  ? 209 THR A N   1 
ATOM   1414 C CA  . THR A 1 184 ? -17.167 -3.564  -1.985  1.00 8.34  ? 209 THR A CA  1 
ATOM   1415 C C   . THR A 1 184 ? -15.873 -3.017  -2.561  1.00 8.21  ? 209 THR A C   1 
ATOM   1416 O O   . THR A 1 184 ? -15.793 -1.839  -2.923  1.00 9.37  ? 209 THR A O   1 
ATOM   1417 C CB  . THR A 1 184 ? -17.064 -3.729  -0.466  1.00 9.65  ? 209 THR A CB  1 
ATOM   1418 O OG1 . THR A 1 184 ? -18.364 -4.043  0.061   1.00 12.22 ? 209 THR A OG1 1 
ATOM   1419 C CG2 . THR A 1 184 ? -16.557 -2.447  0.195   1.00 11.12 ? 209 THR A CG2 1 
ATOM   1420 N N   . TRP A 1 185 ? -14.850 -3.865  -2.683  1.00 9.03  ? 210 TRP A N   1 
ATOM   1421 C CA  . TRP A 1 185 ? -13.580 -3.413  -3.238  1.00 9.18  ? 210 TRP A CA  1 
ATOM   1422 C C   . TRP A 1 185 ? -13.732 -2.941  -4.684  1.00 9.54  ? 210 TRP A C   1 
ATOM   1423 O O   . TRP A 1 185 ? -13.215 -1.878  -5.059  1.00 9.75  ? 210 TRP A O   1 
ATOM   1424 C CB  . TRP A 1 185 ? -12.537 -4.531  -3.144  1.00 8.41  ? 210 TRP A CB  1 
ATOM   1425 C CG  . TRP A 1 185 ? -11.908 -4.681  -1.773  1.00 8.99  ? 210 TRP A CG  1 
ATOM   1426 C CD1 . TRP A 1 185 ? -11.764 -3.711  -0.819  1.00 10.58 ? 210 TRP A CD1 1 
ATOM   1427 C CD2 . TRP A 1 185 ? -11.350 -5.879  -1.210  1.00 8.53  ? 210 TRP A CD2 1 
ATOM   1428 N NE1 . TRP A 1 185 ? -11.139 -4.230  0.295   1.00 11.13 ? 210 TRP A NE1 1 
ATOM   1429 C CE2 . TRP A 1 185 ? -10.881 -5.558  0.080   1.00 8.95  ? 210 TRP A CE2 1 
ATOM   1430 C CE3 . TRP A 1 185 ? -11.216 -7.193  -1.666  1.00 10.15 ? 210 TRP A CE3 1 
ATOM   1431 C CZ2 . TRP A 1 185 ? -10.267 -6.503  0.910   1.00 10.26 ? 210 TRP A CZ2 1 
ATOM   1432 C CZ3 . TRP A 1 185 ? -10.607 -8.127  -0.843  1.00 10.53 ? 210 TRP A CZ3 1 
ATOM   1433 C CH2 . TRP A 1 185 ? -10.154 -7.776  0.437   1.00 10.12 ? 210 TRP A CH2 1 
ATOM   1434 N N   . LEU A 1 186 ? -14.423 -3.730  -5.518  1.00 8.54  ? 211 LEU A N   1 
ATOM   1435 C CA  . LEU A 1 186 ? -14.591 -3.361  -6.922  1.00 7.23  ? 211 LEU A CA  1 
ATOM   1436 C C   . LEU A 1 186 ? -15.361 -2.054  -7.069  1.00 9.16  ? 211 LEU A C   1 
ATOM   1437 O O   . LEU A 1 186 ? -15.032 -1.219  -7.921  1.00 8.56  ? 211 LEU A O   1 
ATOM   1438 C CB  . LEU A 1 186 ? -15.307 -4.482  -7.671  1.00 10.25 ? 211 LEU A CB  1 
ATOM   1439 C CG  . LEU A 1 186 ? -14.577 -5.802  -7.858  1.00 9.94  ? 211 LEU A CG  1 
ATOM   1440 C CD1 . LEU A 1 186 ? -15.533 -6.830  -8.429  1.00 10.99 ? 211 LEU A CD1 1 
ATOM   1441 C CD2 . LEU A 1 186 ? -13.382 -5.597  -8.782  1.00 10.72 ? 211 LEU A CD2 1 
ATOM   1442 N N   . LYS A 1 187 ? -16.388 -1.854  -6.233  1.00 9.05  ? 212 LYS A N   1 
ATOM   1443 C CA  . LYS A 1 187 ? -17.183 -0.638  -6.320  1.00 8.58  ? 212 LYS A CA  1 
ATOM   1444 C C   . LYS A 1 187 ? -16.372 0.587   -5.927  1.00 9.49  ? 212 LYS A C   1 
ATOM   1445 O O   . LYS A 1 187 ? -16.695 1.703   -6.345  1.00 10.03 ? 212 LYS A O   1 
ATOM   1446 C CB  . LYS A 1 187 ? -18.415 -0.765  -5.423  1.00 8.10  ? 212 LYS A CB  1 
ATOM   1447 C CG  . LYS A 1 187 ? -19.557 -1.534  -6.029  1.00 10.27 ? 212 LYS A CG  1 
ATOM   1448 C CD  . LYS A 1 187 ? -20.753 -1.479  -5.076  1.00 12.20 ? 212 LYS A CD  1 
ATOM   1449 C CE  . LYS A 1 187 ? -21.844 -2.434  -5.462  1.00 14.95 ? 212 LYS A CE  1 
ATOM   1450 N NZ  . LYS A 1 187 ? -22.952 -2.315  -4.458  1.00 18.36 ? 212 LYS A NZ  1 
ATOM   1451 N N   . GLY A 1 188 ? -15.333 0.405   -5.125  1.00 7.44  ? 213 GLY A N   1 
ATOM   1452 C CA  . GLY A 1 188 ? -14.471 1.484   -4.698  1.00 7.19  ? 213 GLY A CA  1 
ATOM   1453 C C   . GLY A 1 188 ? -13.250 1.683   -5.572  1.00 6.35  ? 213 GLY A C   1 
ATOM   1454 O O   . GLY A 1 188 ? -12.326 2.402   -5.185  1.00 8.93  ? 213 GLY A O   1 
ATOM   1455 N N   . ASN A 1 189 ? -13.198 1.035   -6.734  1.00 7.74  ? 214 ASN A N   1 
ATOM   1456 C CA  . ASN A 1 189 ? -12.070 1.227   -7.637  1.00 8.34  ? 214 ASN A CA  1 
ATOM   1457 C C   . ASN A 1 189 ? -11.860 2.704   -7.963  1.00 7.26  ? 214 ASN A C   1 
ATOM   1458 O O   . ASN A 1 189 ? -12.818 3.446   -8.184  1.00 8.40  ? 214 ASN A O   1 
ATOM   1459 C CB  . ASN A 1 189 ? -12.293 0.447   -8.938  1.00 8.37  ? 214 ASN A CB  1 
ATOM   1460 C CG  . ASN A 1 189 ? -11.116 0.555   -9.865  1.00 7.55  ? 214 ASN A CG  1 
ATOM   1461 O OD1 . ASN A 1 189 ? -9.978  0.671   -9.414  1.00 10.04 ? 214 ASN A OD1 1 
ATOM   1462 N ND2 . ASN A 1 189 ? -11.376 0.532   -11.174 1.00 11.65 ? 214 ASN A ND2 1 
ATOM   1463 N N   . THR A 1 190 ? -10.591 3.124   -8.012  1.00 6.84  ? 215 THR A N   1 
ATOM   1464 C CA  . THR A 1 190 ? -10.274 4.504   -8.374  1.00 7.98  ? 215 THR A CA  1 
ATOM   1465 C C   . THR A 1 190 ? -9.904  4.677   -9.840  1.00 10.35 ? 215 THR A C   1 
ATOM   1466 O O   . THR A 1 190 ? -9.825  5.816   -10.297 1.00 9.94  ? 215 THR A O   1 
ATOM   1467 C CB  . THR A 1 190 ? -9.122  5.059   -7.522  1.00 8.65  ? 215 THR A CB  1 
ATOM   1468 O OG1 . THR A 1 190 ? -7.882  4.430   -7.887  1.00 9.44  ? 215 THR A OG1 1 
ATOM   1469 C CG2 . THR A 1 190 ? -9.393  4.865   -6.039  1.00 9.96  ? 215 THR A CG2 1 
ATOM   1470 N N   . THR A 1 191 ? -9.681  3.592   -10.588 1.00 9.14  ? 216 THR A N   1 
ATOM   1471 C CA  . THR A 1 191 ? -9.054  3.670   -11.906 1.00 9.85  ? 216 THR A CA  1 
ATOM   1472 C C   . THR A 1 191 ? -10.028 3.547   -13.067 1.00 6.89  ? 216 THR A C   1 
ATOM   1473 O O   . THR A 1 191 ? -9.578  3.543   -14.219 1.00 10.37 ? 216 THR A O   1 
ATOM   1474 C CB  . THR A 1 191 ? -7.979  2.589   -12.073 1.00 9.37  ? 216 THR A CB  1 
ATOM   1475 O OG1 . THR A 1 191 ? -8.601  1.297   -12.166 1.00 10.16 ? 216 THR A OG1 1 
ATOM   1476 C CG2 . THR A 1 191 ? -6.971  2.609   -10.941 1.00 9.47  ? 216 THR A CG2 1 
ATOM   1477 N N   . GLY A 1 192 ? -11.334 3.501   -12.816 1.00 7.87  ? 217 GLY A N   1 
ATOM   1478 C CA  . GLY A 1 192 ? -12.261 3.029   -13.829 1.00 8.43  ? 217 GLY A CA  1 
ATOM   1479 C C   . GLY A 1 192 ? -13.134 4.014   -14.580 1.00 9.15  ? 217 GLY A C   1 
ATOM   1480 O O   . GLY A 1 192 ? -13.823 3.611   -15.514 1.00 9.57  ? 217 GLY A O   1 
ATOM   1481 N N   . ALA A 1 193 ? -13.112 5.304   -14.226 1.00 8.16  ? 218 ALA A N   1 
ATOM   1482 C CA  . ALA A 1 193 ? -14.092 6.239   -14.768 1.00 9.03  ? 218 ALA A CA  1 
ATOM   1483 C C   . ALA A 1 193 ? -13.991 6.458   -16.281 1.00 8.55  ? 218 ALA A C   1 
ATOM   1484 O O   . ALA A 1 193 ? -14.983 6.908   -16.875 1.00 12.26 ? 218 ALA A O   1 
ATOM   1485 C CB  . ALA A 1 193 ? -13.975 7.586   -14.050 1.00 9.53  ? 218 ALA A CB  1 
ATOM   1486 N N   . ALA A 1 194 ? -12.838 6.182   -16.913 1.00 9.42  ? 219 ALA A N   1 
ATOM   1487 C CA  . ALA A 1 194 ? -12.664 6.381   -18.349 1.00 10.12 ? 219 ALA A CA  1 
ATOM   1488 C C   . ALA A 1 194 ? -12.982 5.141   -19.171 1.00 8.10  ? 219 ALA A C   1 
ATOM   1489 O O   . ALA A 1 194 ? -12.957 5.214   -20.404 1.00 9.77  ? 219 ALA A O   1 
ATOM   1490 C CB  . ALA A 1 194 ? -11.225 6.828   -18.662 1.00 9.46  ? 219 ALA A CB  1 
ATOM   1491 N N   . SER A 1 195 ? -13.266 4.013   -18.536 1.00 7.78  ? 220 SER A N   1 
ATOM   1492 C CA  . SER A 1 195 ? -13.348 2.723   -19.224 1.00 9.25  ? 220 SER A CA  1 
ATOM   1493 C C   . SER A 1 195 ? -14.820 2.317   -19.350 1.00 9.55  ? 220 SER A C   1 
ATOM   1494 O O   . SER A 1 195 ? -15.614 3.126   -19.851 1.00 9.13  ? 220 SER A O   1 
ATOM   1495 C CB  . SER A 1 195 ? -12.437 1.726   -18.517 1.00 8.23  ? 220 SER A CB  1 
ATOM   1496 O OG  . SER A 1 195 ? -11.094 2.199   -18.567 1.00 7.95  ? 220 SER A OG  1 
ATOM   1497 N N   . ILE A 1 196 ? -15.219 1.109   -18.935 1.00 8.42  ? 221 ILE A N   1 
ATOM   1498 C CA  . ILE A 1 196 ? -16.611 0.677   -19.114 1.00 9.50  ? 221 ILE A CA  1 
ATOM   1499 C C   . ILE A 1 196 ? -17.584 1.724   -18.570 1.00 10.90 ? 221 ILE A C   1 
ATOM   1500 O O   . ILE A 1 196 ? -18.565 2.075   -19.229 1.00 11.45 ? 221 ILE A O   1 
ATOM   1501 C CB  . ILE A 1 196 ? -16.834 -0.707  -18.473 1.00 6.07  ? 221 ILE A CB  1 
ATOM   1502 C CG1 . ILE A 1 196 ? -16.233 -1.793  -19.371 1.00 8.71  ? 221 ILE A CG1 1 
ATOM   1503 C CG2 . ILE A 1 196 ? -18.318 -0.957  -18.244 1.00 10.67 ? 221 ILE A CG2 1 
ATOM   1504 C CD1 . ILE A 1 196 ? -16.102 -3.162  -18.690 1.00 9.38  ? 221 ILE A CD1 1 
ATOM   1505 N N   A ARG A 1 197 ? -17.313 2.241   -17.364 0.59 9.22  ? 222 ARG A N   1 
ATOM   1506 N N   B ARG A 1 197 ? -17.303 2.244   -17.369 0.41 9.29  ? 222 ARG A N   1 
ATOM   1507 C CA  A ARG A 1 197 ? -18.182 3.236   -16.731 0.59 11.61 ? 222 ARG A CA  1 
ATOM   1508 C CA  B ARG A 1 197 ? -18.162 3.236   -16.722 0.41 11.66 ? 222 ARG A CA  1 
ATOM   1509 C C   A ARG A 1 197 ? -18.518 4.395   -17.659 0.59 12.25 ? 222 ARG A C   1 
ATOM   1510 C C   B ARG A 1 197 ? -18.507 4.400   -17.642 0.41 12.24 ? 222 ARG A C   1 
ATOM   1511 O O   A ARG A 1 197 ? -19.648 4.899   -17.649 0.59 13.29 ? 222 ARG A O   1 
ATOM   1512 O O   B ARG A 1 197 ? -19.635 4.909   -17.614 0.41 13.30 ? 222 ARG A O   1 
ATOM   1513 C CB  A ARG A 1 197 ? -17.513 3.788   -15.473 0.59 14.71 ? 222 ARG A CB  1 
ATOM   1514 C CB  B ARG A 1 197 ? -17.473 3.768   -15.465 0.41 14.70 ? 222 ARG A CB  1 
ATOM   1515 C CG  A ARG A 1 197 ? -17.497 2.861   -14.288 0.59 22.28 ? 222 ARG A CG  1 
ATOM   1516 C CG  B ARG A 1 197 ? -18.385 3.999   -14.282 0.41 24.03 ? 222 ARG A CG  1 
ATOM   1517 C CD  A ARG A 1 197 ? -16.595 3.437   -13.226 0.59 17.32 ? 222 ARG A CD  1 
ATOM   1518 C CD  B ARG A 1 197 ? -17.559 4.379   -13.070 0.41 16.82 ? 222 ARG A CD  1 
ATOM   1519 N NE  A ARG A 1 197 ? -16.094 2.420   -12.317 0.59 17.69 ? 222 ARG A NE  1 
ATOM   1520 N NE  B ARG A 1 197 ? -17.200 5.790   -13.098 0.41 27.38 ? 222 ARG A NE  1 
ATOM   1521 C CZ  A ARG A 1 197 ? -16.518 2.271   -11.072 0.59 17.80 ? 222 ARG A CZ  1 
ATOM   1522 C CZ  B ARG A 1 197 ? -17.704 6.699   -12.276 0.41 16.49 ? 222 ARG A CZ  1 
ATOM   1523 N NH1 A ARG A 1 197 ? -17.444 3.067   -10.557 0.59 16.85 ? 222 ARG A NH1 1 
ATOM   1524 N NH1 B ARG A 1 197 ? -18.541 6.361   -11.308 0.41 14.39 ? 222 ARG A NH1 1 
ATOM   1525 N NH2 A ARG A 1 197 ? -16.002 1.302   -10.325 0.59 16.95 ? 222 ARG A NH2 1 
ATOM   1526 N NH2 B ARG A 1 197 ? -17.360 7.974   -12.429 0.41 14.07 ? 222 ARG A NH2 1 
ATOM   1527 N N   . ALA A 1 198 ? -17.550 4.845   -18.456 1.00 10.67 ? 223 ALA A N   1 
ATOM   1528 C CA  . ALA A 1 198 ? -17.776 6.032   -19.282 1.00 11.97 ? 223 ALA A CA  1 
ATOM   1529 C C   . ALA A 1 198 ? -18.806 5.800   -20.379 1.00 14.19 ? 223 ALA A C   1 
ATOM   1530 O O   . ALA A 1 198 ? -19.375 6.771   -20.892 1.00 16.69 ? 223 ALA A O   1 
ATOM   1531 C CB  . ALA A 1 198 ? -16.464 6.512   -19.895 1.00 10.68 ? 223 ALA A CB  1 
ATOM   1532 N N   . GLY A 1 199 ? -19.045 4.554   -20.770 1.00 11.14 ? 224 GLY A N   1 
ATOM   1533 C CA  . GLY A 1 199 ? -20.053 4.274   -21.767 1.00 12.76 ? 224 GLY A CA  1 
ATOM   1534 C C   . GLY A 1 199 ? -21.424 3.970   -21.224 1.00 13.20 ? 224 GLY A C   1 
ATOM   1535 O O   . GLY A 1 199 ? -22.345 3.682   -22.000 1.00 14.97 ? 224 GLY A O   1 
ATOM   1536 N N   . LEU A 1 200 ? -21.603 4.042   -19.908 1.00 13.62 ? 225 LEU A N   1 
ATOM   1537 C CA  . LEU A 1 200 ? -22.858 3.660   -19.277 1.00 11.56 ? 225 LEU A CA  1 
ATOM   1538 C C   . LEU A 1 200 ? -23.544 4.869   -18.656 1.00 16.29 ? 225 LEU A C   1 
ATOM   1539 O O   . LEU A 1 200 ? -22.882 5.837   -18.286 1.00 14.21 ? 225 LEU A O   1 
ATOM   1540 C CB  . LEU A 1 200 ? -22.625 2.607   -18.186 1.00 12.98 ? 225 LEU A CB  1 
ATOM   1541 C CG  . LEU A 1 200 ? -21.904 1.336   -18.633 1.00 14.10 ? 225 LEU A CG  1 
ATOM   1542 C CD1 . LEU A 1 200 ? -21.731 0.411   -17.443 1.00 15.00 ? 225 LEU A CD1 1 
ATOM   1543 C CD2 . LEU A 1 200 ? -22.685 0.641   -19.739 1.00 15.28 ? 225 LEU A CD2 1 
ATOM   1544 N N   . PRO A 1 201 ? -24.868 4.833   -18.507 1.00 15.31 ? 226 PRO A N   1 
ATOM   1545 C CA  . PRO A 1 201 ? -25.562 5.919   -17.803 1.00 17.35 ? 226 PRO A CA  1 
ATOM   1546 C C   . PRO A 1 201 ? -24.979 6.129   -16.414 1.00 14.15 ? 226 PRO A C   1 
ATOM   1547 O O   . PRO A 1 201 ? -24.646 5.174   -15.712 1.00 16.84 ? 226 PRO A O   1 
ATOM   1548 C CB  . PRO A 1 201 ? -27.011 5.424   -17.733 1.00 16.34 ? 226 PRO A CB  1 
ATOM   1549 C CG  . PRO A 1 201 ? -27.145 4.490   -18.891 1.00 18.93 ? 226 PRO A CG  1 
ATOM   1550 C CD  . PRO A 1 201 ? -25.799 3.821   -19.030 1.00 18.36 ? 226 PRO A CD  1 
ATOM   1551 N N   . THR A 1 202 ? -24.892 7.399   -16.008 1.00 17.42 ? 227 THR A N   1 
ATOM   1552 C CA  . THR A 1 202 ? -24.245 7.736   -14.745 1.00 18.76 ? 227 THR A CA  1 
ATOM   1553 C C   . THR A 1 202 ? -25.008 7.172   -13.553 1.00 20.34 ? 227 THR A C   1 
ATOM   1554 O O   . THR A 1 202 ? -24.401 6.854   -12.523 1.00 24.86 ? 227 THR A O   1 
ATOM   1555 C CB  . THR A 1 202 ? -24.088 9.257   -14.642 1.00 28.10 ? 227 THR A CB  1 
ATOM   1556 O OG1 . THR A 1 202 ? -22.968 9.663   -15.439 1.00 39.38 ? 227 THR A OG1 1 
ATOM   1557 C CG2 . THR A 1 202 ? -23.848 9.700   -13.199 1.00 30.61 ? 227 THR A CG2 1 
ATOM   1558 N N   . SER A 1 203 ? -26.322 6.995   -13.685 1.00 16.34 ? 228 SER A N   1 
ATOM   1559 C CA  . SER A 1 203 ? -27.115 6.494   -12.574 1.00 19.10 ? 228 SER A CA  1 
ATOM   1560 C C   . SER A 1 203 ? -26.841 5.031   -12.260 1.00 20.11 ? 228 SER A C   1 
ATOM   1561 O O   . SER A 1 203 ? -27.244 4.560   -11.191 1.00 22.85 ? 228 SER A O   1 
ATOM   1562 C CB  . SER A 1 203 ? -28.603 6.698   -12.872 1.00 21.55 ? 228 SER A CB  1 
ATOM   1563 O OG  . SER A 1 203 ? -29.003 5.917   -13.986 1.00 22.66 ? 228 SER A OG  1 
ATOM   1564 N N   . TRP A 1 204 ? -26.178 4.301   -13.150 1.00 16.81 ? 229 TRP A N   1 
ATOM   1565 C CA  . TRP A 1 204 ? -25.904 2.893   -12.899 1.00 16.16 ? 229 TRP A CA  1 
ATOM   1566 C C   . TRP A 1 204 ? -24.710 2.730   -11.972 1.00 16.54 ? 229 TRP A C   1 
ATOM   1567 O O   . TRP A 1 204 ? -23.774 3.531   -11.979 1.00 21.05 ? 229 TRP A O   1 
ATOM   1568 C CB  . TRP A 1 204 ? -25.630 2.135   -14.200 1.00 13.61 ? 229 TRP A CB  1 
ATOM   1569 C CG  . TRP A 1 204 ? -26.752 2.146   -15.205 1.00 17.02 ? 229 TRP A CG  1 
ATOM   1570 C CD1 . TRP A 1 204 ? -27.913 2.862   -15.143 1.00 18.76 ? 229 TRP A CD1 1 
ATOM   1571 C CD2 . TRP A 1 204 ? -26.834 1.347   -16.392 1.00 15.88 ? 229 TRP A CD2 1 
ATOM   1572 N NE1 . TRP A 1 204 ? -28.699 2.583   -16.236 1.00 19.65 ? 229 TRP A NE1 1 
ATOM   1573 C CE2 . TRP A 1 204 ? -28.059 1.655   -17.018 1.00 16.85 ? 229 TRP A CE2 1 
ATOM   1574 C CE3 . TRP A 1 204 ? -25.983 0.413   -16.997 1.00 15.85 ? 229 TRP A CE3 1 
ATOM   1575 C CZ2 . TRP A 1 204 ? -28.455 1.063   -18.218 1.00 20.79 ? 229 TRP A CZ2 1 
ATOM   1576 C CZ3 . TRP A 1 204 ? -26.380 -0.179  -18.189 1.00 19.75 ? 229 TRP A CZ3 1 
ATOM   1577 C CH2 . TRP A 1 204 ? -27.608 0.149   -18.785 1.00 20.13 ? 229 TRP A CH2 1 
ATOM   1578 N N   . THR A 1 205 ? -24.742 1.664   -11.180 1.00 14.02 ? 230 THR A N   1 
ATOM   1579 C CA  . THR A 1 205 ? -23.682 1.373   -10.223 1.00 11.55 ? 230 THR A CA  1 
ATOM   1580 C C   . THR A 1 205 ? -22.731 0.363   -10.835 1.00 13.38 ? 230 THR A C   1 
ATOM   1581 O O   . THR A 1 205 ? -23.174 -0.663  -11.353 1.00 14.22 ? 230 THR A O   1 
ATOM   1582 C CB  . THR A 1 205 ? -24.254 0.815   -8.922  1.00 17.64 ? 230 THR A CB  1 
ATOM   1583 O OG1 . THR A 1 205 ? -25.113 1.793   -8.322  1.00 23.72 ? 230 THR A OG1 1 
ATOM   1584 C CG2 . THR A 1 205 ? -23.126 0.456   -7.959  1.00 14.07 ? 230 THR A CG2 1 
ATOM   1585 N N   . VAL A 1 206 ? -21.434 0.654   -10.770 1.00 10.68 ? 231 VAL A N   1 
ATOM   1586 C CA  . VAL A 1 206 ? -20.417 -0.170  -11.410 1.00 11.06 ? 231 VAL A CA  1 
ATOM   1587 C C   . VAL A 1 206 ? -19.332 -0.528  -10.399 1.00 10.42 ? 231 VAL A C   1 
ATOM   1588 O O   . VAL A 1 206 ? -18.888 0.318   -9.612  1.00 11.27 ? 231 VAL A O   1 
ATOM   1589 C CB  . VAL A 1 206 ? -19.794 0.549   -12.626 1.00 10.66 ? 231 VAL A CB  1 
ATOM   1590 C CG1 . VAL A 1 206 ? -18.709 -0.319  -13.241 1.00 13.38 ? 231 VAL A CG1 1 
ATOM   1591 C CG2 . VAL A 1 206 ? -20.865 0.889   -13.655 1.00 14.21 ? 231 VAL A CG2 1 
ATOM   1592 N N   . GLY A 1 207 ? -18.924 -1.790  -10.406 1.00 8.88  ? 232 GLY A N   1 
ATOM   1593 C CA  . GLY A 1 207 ? -17.681 -2.188  -9.773  1.00 9.36  ? 232 GLY A CA  1 
ATOM   1594 C C   . GLY A 1 207 ? -16.790 -2.782  -10.844 1.00 7.71  ? 232 GLY A C   1 
ATOM   1595 O O   . GLY A 1 207 ? -17.270 -3.601  -11.632 1.00 10.20 ? 232 GLY A O   1 
ATOM   1596 N N   . ASP A 1 208 ? -15.530 -2.365  -10.941 1.00 7.14  ? 233 ASP A N   1 
ATOM   1597 C CA  . ASP A 1 208 ? -14.716 -2.803  -12.071 1.00 7.42  ? 233 ASP A CA  1 
ATOM   1598 C C   . ASP A 1 208 ? -13.257 -2.940  -11.663 1.00 7.99  ? 233 ASP A C   1 
ATOM   1599 O O   . ASP A 1 208 ? -12.815 -2.443  -10.616 1.00 7.64  ? 233 ASP A O   1 
ATOM   1600 C CB  . ASP A 1 208 ? -14.831 -1.838  -13.268 1.00 8.45  ? 233 ASP A CB  1 
ATOM   1601 C CG  . ASP A 1 208 ? -13.924 -0.629  -13.128 1.00 11.97 ? 233 ASP A CG  1 
ATOM   1602 O OD1 . ASP A 1 208 ? -14.171 0.191   -12.218 1.00 11.22 ? 233 ASP A OD1 1 
ATOM   1603 O OD2 . ASP A 1 208 ? -12.950 -0.499  -13.908 1.00 10.67 ? 233 ASP A OD2 1 
ATOM   1604 N N   . LYS A 1 209 ? -12.502 -3.624  -12.523 1.00 6.73  ? 234 LYS A N   1 
ATOM   1605 C CA  . LYS A 1 209 ? -11.046 -3.649  -12.430 1.00 5.84  ? 234 LYS A CA  1 
ATOM   1606 C C   . LYS A 1 209 ? -10.467 -3.445  -13.815 1.00 9.01  ? 234 LYS A C   1 
ATOM   1607 O O   . LYS A 1 209 ? -10.778 -4.216  -14.731 1.00 7.30  ? 234 LYS A O   1 
ATOM   1608 C CB  . LYS A 1 209 ? -10.547 -4.976  -11.857 1.00 8.15  ? 234 LYS A CB  1 
ATOM   1609 C CG  . LYS A 1 209 ? -9.020  -5.092  -11.792 1.00 8.48  ? 234 LYS A CG  1 
ATOM   1610 C CD  . LYS A 1 209 ? -8.502  -4.185  -10.681 1.00 8.58  ? 234 LYS A CD  1 
ATOM   1611 C CE  . LYS A 1 209 ? -6.997  -3.978  -10.776 1.00 7.28  ? 234 LYS A CE  1 
ATOM   1612 N NZ  . LYS A 1 209 ? -6.671  -2.857  -11.730 1.00 9.37  ? 234 LYS A NZ  1 
ATOM   1613 N N   . THR A 1 210 ? -9.609  -2.436  -13.959 1.00 8.66  ? 235 THR A N   1 
ATOM   1614 C CA  . THR A 1 210 ? -8.972  -2.127  -15.226 1.00 6.61  ? 235 THR A CA  1 
ATOM   1615 C C   . THR A 1 210 ? -7.674  -2.911  -15.381 1.00 9.00  ? 235 THR A C   1 
ATOM   1616 O O   . THR A 1 210 ? -7.157  -3.502  -14.433 1.00 9.33  ? 235 THR A O   1 
ATOM   1617 C CB  . THR A 1 210 ? -8.677  -0.631  -15.332 1.00 9.16  ? 235 THR A CB  1 
ATOM   1618 O OG1 . THR A 1 210 ? -7.846  -0.240  -14.226 1.00 11.90 ? 235 THR A OG1 1 
ATOM   1619 C CG2 . THR A 1 210 ? -9.981  0.186   -15.308 1.00 10.69 ? 235 THR A CG2 1 
ATOM   1620 N N   . GLY A 1 211 ? -7.146  -2.898  -16.599 1.00 7.95  ? 236 GLY A N   1 
ATOM   1621 C CA  . GLY A 1 211 ? -5.801  -3.397  -16.842 1.00 9.66  ? 236 GLY A CA  1 
ATOM   1622 C C   . GLY A 1 211 ? -5.177  -2.674  -18.011 1.00 8.91  ? 236 GLY A C   1 
ATOM   1623 O O   . GLY A 1 211 ? -5.873  -2.215  -18.923 1.00 10.26 ? 236 GLY A O   1 
ATOM   1624 N N   . SER A 1 212 ? -3.849  -2.578  -17.985 1.00 8.56  ? 237 SER A N   1 
ATOM   1625 C CA  . SER A 1 212 ? -3.123  -2.038  -19.121 1.00 9.20  ? 237 SER A CA  1 
ATOM   1626 C C   . SER A 1 212 ? -1.768  -2.714  -19.217 1.00 9.40  ? 237 SER A C   1 
ATOM   1627 O O   . SER A 1 212 ? -1.231  -3.201  -18.224 1.00 11.82 ? 237 SER A O   1 
ATOM   1628 C CB  . SER A 1 212 ? -2.959  -0.521  -19.005 1.00 17.63 ? 237 SER A CB  1 
ATOM   1629 O OG  . SER A 1 212 ? -2.225  -0.189  -17.847 1.00 23.83 ? 237 SER A OG  1 
ATOM   1630 N N   . GLY A 1 213 ? -1.227  -2.740  -20.425 1.00 9.61  ? 238 GLY A N   1 
ATOM   1631 C CA  . GLY A 1 213 ? 0.097   -3.284  -20.609 1.00 12.19 ? 238 GLY A CA  1 
ATOM   1632 C C   . GLY A 1 213 ? 0.657   -2.924  -21.960 1.00 10.91 ? 238 GLY A C   1 
ATOM   1633 O O   . GLY A 1 213 ? 0.187   -1.995  -22.625 1.00 12.51 ? 238 GLY A O   1 
ATOM   1634 N N   . ASP A 1 214 ? 1.681   -3.676  -22.351 1.00 11.39 ? 240 ASP A N   1 
ATOM   1635 C CA  . ASP A 1 214 ? 2.335   -3.440  -23.627 1.00 10.49 ? 240 ASP A CA  1 
ATOM   1636 C C   . ASP A 1 214 ? 1.362   -3.740  -24.762 1.00 10.55 ? 240 ASP A C   1 
ATOM   1637 O O   . ASP A 1 214 ? 0.263   -4.261  -24.555 1.00 10.37 ? 240 ASP A O   1 
ATOM   1638 C CB  . ASP A 1 214 ? 3.587   -4.304  -23.755 1.00 13.14 ? 240 ASP A CB  1 
ATOM   1639 C CG  . ASP A 1 214 ? 4.730   -3.823  -22.877 1.00 20.64 ? 240 ASP A CG  1 
ATOM   1640 O OD1 . ASP A 1 214 ? 4.655   -2.699  -22.333 1.00 20.37 ? 240 ASP A OD1 1 
ATOM   1641 O OD2 . ASP A 1 214 ? 5.706   -4.586  -22.719 1.00 20.03 ? 240 ASP A OD2 1 
ATOM   1642 N N   . TYR A 1 215 ? 1.775   -3.396  -25.980 1.00 10.63 ? 241 TYR A N   1 
ATOM   1643 C CA  . TYR A 1 215 ? 0.917   -3.495  -27.162 1.00 8.78  ? 241 TYR A CA  1 
ATOM   1644 C C   . TYR A 1 215 ? -0.394  -2.722  -26.976 1.00 9.44  ? 241 TYR A C   1 
ATOM   1645 O O   . TYR A 1 215 ? -1.431  -3.085  -27.539 1.00 11.17 ? 241 TYR A O   1 
ATOM   1646 C CB  . TYR A 1 215 ? 0.668   -4.962  -27.547 1.00 11.39 ? 241 TYR A CB  1 
ATOM   1647 C CG  . TYR A 1 215 ? 1.903   -5.592  -28.145 1.00 13.03 ? 241 TYR A CG  1 
ATOM   1648 C CD1 . TYR A 1 215 ? 2.869   -6.175  -27.338 1.00 10.22 ? 241 TYR A CD1 1 
ATOM   1649 C CD2 . TYR A 1 215 ? 2.123   -5.549  -29.509 1.00 11.61 ? 241 TYR A CD2 1 
ATOM   1650 C CE1 . TYR A 1 215 ? 4.027   -6.740  -27.884 1.00 14.07 ? 241 TYR A CE1 1 
ATOM   1651 C CE2 . TYR A 1 215 ? 3.277   -6.098  -30.071 1.00 12.49 ? 241 TYR A CE2 1 
ATOM   1652 C CZ  . TYR A 1 215 ? 4.220   -6.690  -29.253 1.00 17.85 ? 241 TYR A CZ  1 
ATOM   1653 O OH  . TYR A 1 215 ? 5.355   -7.230  -29.839 1.00 22.46 ? 241 TYR A OH  1 
ATOM   1654 N N   . GLY A 1 216 ? -0.327  -1.607  -26.243 1.00 8.36  ? 242 GLY A N   1 
ATOM   1655 C CA  . GLY A 1 216 ? -1.495  -0.780  -26.011 1.00 11.94 ? 242 GLY A CA  1 
ATOM   1656 C C   . GLY A 1 216 ? -2.666  -1.546  -25.438 1.00 8.23  ? 242 GLY A C   1 
ATOM   1657 O O   . GLY A 1 216 ? -3.831  -1.218  -25.701 1.00 10.84 ? 242 GLY A O   1 
ATOM   1658 N N   . THR A 1 217 ? -2.368  -2.579  -24.658 1.00 10.71 ? 243 THR A N   1 
ATOM   1659 C CA  . THR A 1 217 ? -3.433  -3.395  -24.100 1.00 10.46 ? 243 THR A CA  1 
ATOM   1660 C C   . THR A 1 217 ? -4.211  -2.569  -23.088 1.00 7.93  ? 243 THR A C   1 
ATOM   1661 O O   . THR A 1 217 ? -3.627  -1.916  -22.215 1.00 10.15 ? 243 THR A O   1 
ATOM   1662 C CB  . THR A 1 217 ? -2.859  -4.666  -23.469 1.00 8.87  ? 243 THR A CB  1 
ATOM   1663 O OG1 . THR A 1 217 ? -2.199  -5.435  -24.486 1.00 10.48 ? 243 THR A OG1 1 
ATOM   1664 C CG2 . THR A 1 217 ? -3.971  -5.506  -22.901 1.00 11.51 ? 243 THR A CG2 1 
ATOM   1665 N N   . THR A 1 218 ? -5.530  -2.550  -23.251 1.00 6.26  ? 244 THR A N   1 
ATOM   1666 C CA  . THR A 1 218 ? -6.411  -1.708  -22.448 1.00 7.74  ? 244 THR A CA  1 
ATOM   1667 C C   . THR A 1 218 ? -7.629  -2.558  -22.124 1.00 9.37  ? 244 THR A C   1 
ATOM   1668 O O   . THR A 1 218 ? -8.379  -2.922  -23.032 1.00 7.71  ? 244 THR A O   1 
ATOM   1669 C CB  . THR A 1 218 ? -6.807  -0.434  -23.208 1.00 8.87  ? 244 THR A CB  1 
ATOM   1670 O OG1 . THR A 1 218 ? -5.654  0.137   -23.848 1.00 9.91  ? 244 THR A OG1 1 
ATOM   1671 C CG2 . THR A 1 218 ? -7.370  0.576   -22.264 1.00 9.10  ? 244 THR A CG2 1 
ATOM   1672 N N   . ASN A 1 219 ? -7.824  -2.885  -20.845 1.00 9.49  ? 245 ASN A N   1 
ATOM   1673 C CA  . ASN A 1 219 ? -8.831  -3.849  -20.421 1.00 7.77  ? 245 ASN A CA  1 
ATOM   1674 C C   . ASN A 1 219 ? -9.707  -3.281  -19.310 1.00 8.13  ? 245 ASN A C   1 
ATOM   1675 O O   . ASN A 1 219 ? -9.300  -2.384  -18.564 1.00 7.58  ? 245 ASN A O   1 
ATOM   1676 C CB  . ASN A 1 219 ? -8.191  -5.145  -19.891 1.00 7.77  ? 245 ASN A CB  1 
ATOM   1677 C CG  . ASN A 1 219 ? -7.319  -5.853  -20.911 1.00 9.66  ? 245 ASN A CG  1 
ATOM   1678 O OD1 . ASN A 1 219 ? -7.542  -5.778  -22.123 1.00 10.23 ? 245 ASN A OD1 1 
ATOM   1679 N ND2 . ASN A 1 219 ? -6.303  -6.553  -20.414 1.00 9.64  ? 245 ASN A ND2 1 
ATOM   1680 N N   . ASP A 1 220 ? -10.901 -3.858  -19.170 1.00 9.15  ? 246 ASP A N   1 
ATOM   1681 C CA  . ASP A 1 220 ? -11.752 -3.565  -18.024 1.00 8.03  ? 246 ASP A CA  1 
ATOM   1682 C C   . ASP A 1 220 ? -12.730 -4.718  -17.847 1.00 10.14 ? 246 ASP A C   1 
ATOM   1683 O O   . ASP A 1 220 ? -13.254 -5.251  -18.830 1.00 9.61  ? 246 ASP A O   1 
ATOM   1684 C CB  . ASP A 1 220 ? -12.523 -2.246  -18.229 1.00 6.73  ? 246 ASP A CB  1 
ATOM   1685 C CG  . ASP A 1 220 ? -13.056 -1.645  -16.932 1.00 10.40 ? 246 ASP A CG  1 
ATOM   1686 O OD1 . ASP A 1 220 ? -12.647 -2.067  -15.837 1.00 10.42 ? 246 ASP A OD1 1 
ATOM   1687 O OD2 . ASP A 1 220 ? -13.882 -0.719  -17.023 1.00 10.27 ? 246 ASP A OD2 1 
ATOM   1688 N N   . ILE A 1 221 ? -12.956 -5.124  -16.600 1.00 7.47  ? 247 ILE A N   1 
ATOM   1689 C CA  . ILE A 1 221 ? -13.961 -6.141  -16.298 1.00 9.66  ? 247 ILE A CA  1 
ATOM   1690 C C   . ILE A 1 221 ? -14.864 -5.586  -15.205 1.00 8.49  ? 247 ILE A C   1 
ATOM   1691 O O   . ILE A 1 221 ? -14.374 -4.991  -14.240 1.00 8.65  ? 247 ILE A O   1 
ATOM   1692 C CB  . ILE A 1 221 ? -13.335 -7.510  -15.919 1.00 8.05  ? 247 ILE A CB  1 
ATOM   1693 C CG1 . ILE A 1 221 ? -12.532 -7.494  -14.602 1.00 9.24  ? 247 ILE A CG1 1 
ATOM   1694 C CG2 . ILE A 1 221 ? -12.428 -8.023  -17.057 1.00 7.42  ? 247 ILE A CG2 1 
ATOM   1695 C CD1 . ILE A 1 221 ? -12.098 -8.907  -14.171 1.00 11.72 ? 247 ILE A CD1 1 
ATOM   1696 N N   . ALA A 1 222 ? -16.179 -5.725  -15.382 1.00 7.30  ? 248 ALA A N   1 
ATOM   1697 C CA  . ALA A 1 222 ? -17.122 -4.984  -14.556 1.00 8.49  ? 248 ALA A CA  1 
ATOM   1698 C C   . ALA A 1 222 ? -18.369 -5.789  -14.213 1.00 9.36  ? 248 ALA A C   1 
ATOM   1699 O O   . ALA A 1 222 ? -18.856 -6.596  -15.005 1.00 9.23  ? 248 ALA A O   1 
ATOM   1700 C CB  . ALA A 1 222 ? -17.568 -3.687  -15.268 1.00 8.83  ? 248 ALA A CB  1 
ATOM   1701 N N   A VAL A 1 223 ? -18.901 -5.549  -13.017 0.46 8.82  ? 249 VAL A N   1 
ATOM   1702 N N   B VAL A 1 223 ? -18.886 -5.549  -13.013 0.54 8.84  ? 249 VAL A N   1 
ATOM   1703 C CA  A VAL A 1 223 ? -20.256 -5.953  -12.665 0.46 9.37  ? 249 VAL A CA  1 
ATOM   1704 C CA  B VAL A 1 223 ? -20.246 -5.912  -12.649 0.54 9.38  ? 249 VAL A CA  1 
ATOM   1705 C C   A VAL A 1 223 ? -21.080 -4.679  -12.511 0.46 9.40  ? 249 VAL A C   1 
ATOM   1706 C C   B VAL A 1 223 ? -21.047 -4.622  -12.595 0.54 9.32  ? 249 VAL A C   1 
ATOM   1707 O O   A VAL A 1 223 ? -20.645 -3.721  -11.862 0.46 9.59  ? 249 VAL A O   1 
ATOM   1708 O O   B VAL A 1 223 ? -20.571 -3.600  -12.089 0.54 9.23  ? 249 VAL A O   1 
ATOM   1709 C CB  A VAL A 1 223 ? -20.288 -6.838  -11.403 0.46 9.33  ? 249 VAL A CB  1 
ATOM   1710 C CB  B VAL A 1 223 ? -20.307 -6.668  -11.310 0.54 9.34  ? 249 VAL A CB  1 
ATOM   1711 C CG1 A VAL A 1 223 ? -19.532 -6.198  -10.242 0.46 8.98  ? 249 VAL A CG1 1 
ATOM   1712 C CG1 B VAL A 1 223 ? -21.731 -7.193  -11.043 0.54 12.54 ? 249 VAL A CG1 1 
ATOM   1713 C CG2 A VAL A 1 223 ? -21.737 -7.180  -11.009 0.46 12.51 ? 249 VAL A CG2 1 
ATOM   1714 C CG2 B VAL A 1 223 ? -19.314 -7.794  -11.323 0.54 11.04 ? 249 VAL A CG2 1 
ATOM   1715 N N   . ILE A 1 224 ? -22.250 -4.659  -13.147 1.00 11.17 ? 250 ILE A N   1 
ATOM   1716 C CA  . ILE A 1 224 ? -23.014 -3.445  -13.391 1.00 11.73 ? 250 ILE A CA  1 
ATOM   1717 C C   . ILE A 1 224 ? -24.406 -3.651  -12.839 1.00 12.16 ? 250 ILE A C   1 
ATOM   1718 O O   . ILE A 1 224 ? -25.049 -4.658  -13.144 1.00 13.51 ? 250 ILE A O   1 
ATOM   1719 C CB  . ILE A 1 224 ? -23.094 -3.122  -14.894 1.00 12.32 ? 250 ILE A CB  1 
ATOM   1720 C CG1 . ILE A 1 224 ? -21.699 -2.959  -15.510 1.00 9.87  ? 250 ILE A CG1 1 
ATOM   1721 C CG2 . ILE A 1 224 ? -23.958 -1.876  -15.131 1.00 13.56 ? 250 ILE A CG2 1 
ATOM   1722 C CD1 . ILE A 1 224 ? -21.683 -3.283  -16.993 1.00 13.82 ? 250 ILE A CD1 1 
ATOM   1723 N N   . TRP A 1 225 ? -24.874 -2.702  -12.035 1.00 13.25 ? 251 TRP A N   1 
ATOM   1724 C CA  . TRP A 1 225 ? -26.248 -2.724  -11.539 1.00 14.45 ? 251 TRP A CA  1 
ATOM   1725 C C   . TRP A 1 225 ? -27.022 -1.599  -12.209 1.00 14.80 ? 251 TRP A C   1 
ATOM   1726 O O   . TRP A 1 225 ? -26.972 -0.443  -11.753 1.00 17.05 ? 251 TRP A O   1 
ATOM   1727 C CB  . TRP A 1 225 ? -26.284 -2.581  -10.019 1.00 16.03 ? 251 TRP A CB  1 
ATOM   1728 C CG  . TRP A 1 225 ? -25.768 -3.780  -9.301  1.00 15.87 ? 251 TRP A CG  1 
ATOM   1729 C CD1 . TRP A 1 225 ? -26.505 -4.818  -8.820  1.00 19.95 ? 251 TRP A CD1 1 
ATOM   1730 C CD2 . TRP A 1 225 ? -24.399 -4.073  -8.985  1.00 12.92 ? 251 TRP A CD2 1 
ATOM   1731 N NE1 . TRP A 1 225 ? -25.688 -5.741  -8.221  1.00 20.01 ? 251 TRP A NE1 1 
ATOM   1732 C CE2 . TRP A 1 225 ? -24.389 -5.310  -8.306  1.00 15.28 ? 251 TRP A CE2 1 
ATOM   1733 C CE3 . TRP A 1 225 ? -23.189 -3.412  -9.206  1.00 15.01 ? 251 TRP A CE3 1 
ATOM   1734 C CZ2 . TRP A 1 225 ? -23.220 -5.892  -7.838  1.00 16.12 ? 251 TRP A CZ2 1 
ATOM   1735 C CZ3 . TRP A 1 225 ? -22.019 -3.998  -8.744  1.00 15.69 ? 251 TRP A CZ3 1 
ATOM   1736 C CH2 . TRP A 1 225 ? -22.049 -5.227  -8.070  1.00 14.97 ? 251 TRP A CH2 1 
ATOM   1737 N N   . PRO A 1 226 ? -27.714 -1.864  -13.310 1.00 13.47 ? 252 PRO A N   1 
ATOM   1738 C CA  . PRO A 1 226 ? -28.452 -0.799  -13.980 1.00 16.82 ? 252 PRO A CA  1 
ATOM   1739 C C   . PRO A 1 226 ? -29.646 -0.401  -13.140 1.00 19.22 ? 252 PRO A C   1 
ATOM   1740 O O   . PRO A 1 226 ? -30.155 -1.175  -12.328 1.00 19.71 ? 252 PRO A O   1 
ATOM   1741 C CB  . PRO A 1 226 ? -28.899 -1.442  -15.298 1.00 19.72 ? 252 PRO A CB  1 
ATOM   1742 C CG  . PRO A 1 226 ? -28.055 -2.684  -15.433 1.00 17.99 ? 252 PRO A CG  1 
ATOM   1743 C CD  . PRO A 1 226 ? -27.871 -3.142  -14.025 1.00 13.31 ? 252 PRO A CD  1 
ATOM   1744 N N   . GLN A 1 227 ? -30.091 0.831   -13.351 1.00 21.87 ? 254 GLN A N   1 
ATOM   1745 C CA  . GLN A 1 227 ? -31.255 1.319   -12.632 1.00 25.40 ? 254 GLN A CA  1 
ATOM   1746 C C   . GLN A 1 227 ? -32.466 0.440   -12.920 1.00 21.19 ? 254 GLN A C   1 
ATOM   1747 O O   . GLN A 1 227 ? -32.890 0.303   -14.072 1.00 25.97 ? 254 GLN A O   1 
ATOM   1748 C CB  . GLN A 1 227 ? -31.535 2.768   -13.018 1.00 33.63 ? 254 GLN A CB  1 
ATOM   1749 C CG  . GLN A 1 227 ? -30.558 3.755   -12.403 1.00 40.31 ? 254 GLN A CG  1 
ATOM   1750 C CD  . GLN A 1 227 ? -30.851 4.040   -10.941 1.00 50.62 ? 254 GLN A CD  1 
ATOM   1751 O OE1 . GLN A 1 227 ? -31.964 3.814   -10.463 1.00 61.87 ? 254 GLN A OE1 1 
ATOM   1752 N NE2 . GLN A 1 227 ? -29.856 4.559   -10.226 1.00 38.16 ? 254 GLN A NE2 1 
ATOM   1753 N N   . GLY A 1 228 ? -32.988 -0.185  -11.872 1.00 17.71 ? 255 GLY A N   1 
ATOM   1754 C CA  . GLY A 1 228 ? -34.249 -0.893  -11.941 1.00 20.07 ? 255 GLY A CA  1 
ATOM   1755 C C   . GLY A 1 228 ? -34.211 -2.261  -12.584 1.00 35.77 ? 255 GLY A C   1 
ATOM   1756 O O   . GLY A 1 228 ? -35.275 -2.805  -12.904 1.00 28.15 ? 255 GLY A O   1 
ATOM   1757 N N   . ARG A 1 229 ? -33.035 -2.847  -12.786 1.00 24.50 ? 256 ARG A N   1 
ATOM   1758 C CA  . ARG A 1 229 ? -32.989 -4.165  -13.399 1.00 24.52 ? 256 ARG A CA  1 
ATOM   1759 C C   . ARG A 1 229 ? -31.834 -4.990  -12.849 1.00 14.00 ? 256 ARG A C   1 
ATOM   1760 O O   . ARG A 1 229 ? -30.992 -4.508  -12.088 1.00 16.29 ? 256 ARG A O   1 
ATOM   1761 C CB  . ARG A 1 229 ? -32.887 -4.081  -14.917 1.00 25.17 ? 256 ARG A CB  1 
ATOM   1762 C CG  . ARG A 1 229 ? -32.213 -2.847  -15.467 1.00 31.17 ? 256 ARG A CG  1 
ATOM   1763 C CD  . ARG A 1 229 ? -31.767 -3.167  -16.864 1.00 41.02 ? 256 ARG A CD  1 
ATOM   1764 N NE  . ARG A 1 229 ? -30.983 -4.390  -16.760 1.00 46.56 ? 256 ARG A NE  1 
ATOM   1765 C CZ  . ARG A 1 229 ? -31.244 -5.536  -17.372 1.00 43.85 ? 256 ARG A CZ  1 
ATOM   1766 N NH1 . ARG A 1 229 ? -32.208 -5.637  -18.277 1.00 41.20 ? 256 ARG A NH1 1 
ATOM   1767 N NH2 . ARG A 1 229 ? -30.535 -6.612  -17.043 1.00 19.38 ? 256 ARG A NH2 1 
ATOM   1768 N N   . ALA A 1 230 ? -31.826 -6.262  -13.244 1.00 14.41 ? 257 ALA A N   1 
ATOM   1769 C CA  . ALA A 1 230 ? -30.848 -7.213  -12.740 1.00 13.99 ? 257 ALA A CA  1 
ATOM   1770 C C   . ALA A 1 230 ? -29.444 -6.872  -13.239 1.00 9.17  ? 257 ALA A C   1 
ATOM   1771 O O   . ALA A 1 230 ? -29.285 -6.244  -14.291 1.00 12.69 ? 257 ALA A O   1 
ATOM   1772 C CB  . ALA A 1 230 ? -31.212 -8.630  -13.173 1.00 14.72 ? 257 ALA A CB  1 
ATOM   1773 N N   . PRO A 1 231 ? -28.415 -7.272  -12.503 1.00 12.07 ? 258 PRO A N   1 
ATOM   1774 C CA  . PRO A 1 231 ? -27.049 -6.886  -12.874 1.00 10.87 ? 258 PRO A CA  1 
ATOM   1775 C C   . PRO A 1 231 ? -26.570 -7.527  -14.159 1.00 12.16 ? 258 PRO A C   1 
ATOM   1776 O O   . PRO A 1 231 ? -27.059 -8.567  -14.617 1.00 12.09 ? 258 PRO A O   1 
ATOM   1777 C CB  . PRO A 1 231 ? -26.205 -7.349  -11.677 1.00 13.50 ? 258 PRO A CB  1 
ATOM   1778 C CG  . PRO A 1 231 ? -27.018 -8.368  -11.002 1.00 20.57 ? 258 PRO A CG  1 
ATOM   1779 C CD  . PRO A 1 231 ? -28.451 -7.932  -11.191 1.00 11.93 ? 258 PRO A CD  1 
ATOM   1780 N N   . LEU A 1 232 ? -25.584 -6.856  -14.741 1.00 12.38 ? 259 LEU A N   1 
ATOM   1781 C CA  . LEU A 1 232 ? -24.843 -7.329  -15.894 1.00 9.45  ? 259 LEU A CA  1 
ATOM   1782 C C   . LEU A 1 232 ? -23.407 -7.593  -15.476 1.00 10.31 ? 259 LEU A C   1 
ATOM   1783 O O   . LEU A 1 232 ? -22.898 -7.002  -14.519 1.00 10.86 ? 259 LEU A O   1 
ATOM   1784 C CB  . LEU A 1 232 ? -24.845 -6.299  -17.027 1.00 11.17 ? 259 LEU A CB  1 
ATOM   1785 C CG  . LEU A 1 232 ? -26.122 -5.503  -17.295 1.00 15.47 ? 259 LEU A CG  1 
ATOM   1786 C CD1 . LEU A 1 232 ? -25.835 -4.321  -18.204 1.00 16.95 ? 259 LEU A CD1 1 
ATOM   1787 C CD2 . LEU A 1 232 ? -27.139 -6.419  -17.918 1.00 18.16 ? 259 LEU A CD2 1 
ATOM   1788 N N   . VAL A 1 233 ? -22.752 -8.479  -16.209 1.00 8.76  ? 260 VAL A N   1 
ATOM   1789 C CA  . VAL A 1 233 ? -21.312 -8.651  -16.127 1.00 7.29  ? 260 VAL A CA  1 
ATOM   1790 C C   . VAL A 1 233 ? -20.762 -8.350  -17.510 1.00 10.51 ? 260 VAL A C   1 
ATOM   1791 O O   . VAL A 1 233 ? -21.300 -8.837  -18.516 1.00 9.82  ? 260 VAL A O   1 
ATOM   1792 C CB  . VAL A 1 233 ? -20.946 -10.072 -15.668 1.00 9.78  ? 260 VAL A CB  1 
ATOM   1793 C CG1 . VAL A 1 233 ? -19.451 -10.254 -15.617 1.00 13.12 ? 260 VAL A CG1 1 
ATOM   1794 C CG2 . VAL A 1 233 ? -21.553 -10.346 -14.294 1.00 13.30 ? 260 VAL A CG2 1 
ATOM   1795 N N   . LEU A 1 234 ? -19.720 -7.525  -17.570 1.00 8.14  ? 261 LEU A N   1 
ATOM   1796 C CA  . LEU A 1 234 ? -19.177 -7.107  -18.858 1.00 7.14  ? 261 LEU A CA  1 
ATOM   1797 C C   . LEU A 1 234 ? -17.664 -7.145  -18.815 1.00 9.36  ? 261 LEU A C   1 
ATOM   1798 O O   . LEU A 1 234 ? -17.045 -6.553  -17.924 1.00 8.31  ? 261 LEU A O   1 
ATOM   1799 C CB  . LEU A 1 234 ? -19.656 -5.700  -19.228 1.00 7.46  ? 261 LEU A CB  1 
ATOM   1800 C CG  . LEU A 1 234 ? -19.198 -5.153  -20.567 1.00 7.60  ? 261 LEU A CG  1 
ATOM   1801 C CD1 . LEU A 1 234 ? -19.681 -6.045  -21.713 1.00 8.37  ? 261 LEU A CD1 1 
ATOM   1802 C CD2 . LEU A 1 234 ? -19.681 -3.721  -20.744 1.00 10.31 ? 261 LEU A CD2 1 
ATOM   1803 N N   . VAL A 1 235 ? -17.078 -7.827  -19.796 1.00 8.13  ? 262 VAL A N   1 
ATOM   1804 C CA  . VAL A 1 235 ? -15.634 -7.862  -19.993 1.00 6.69  ? 262 VAL A CA  1 
ATOM   1805 C C   . VAL A 1 235 ? -15.341 -7.202  -21.331 1.00 9.11  ? 262 VAL A C   1 
ATOM   1806 O O   . VAL A 1 235 ? -15.971 -7.545  -22.337 1.00 8.12  ? 262 VAL A O   1 
ATOM   1807 C CB  . VAL A 1 235 ? -15.103 -9.304  -19.967 1.00 8.31  ? 262 VAL A CB  1 
ATOM   1808 C CG1 . VAL A 1 235 ? -13.664 -9.383  -20.521 1.00 13.62 ? 262 VAL A CG1 1 
ATOM   1809 C CG2 . VAL A 1 235 ? -15.195 -9.843  -18.547 1.00 10.77 ? 262 VAL A CG2 1 
ATOM   1810 N N   . THR A 1 236 ? -14.401 -6.248  -21.343 1.00 7.55  ? 263 THR A N   1 
ATOM   1811 C CA  . THR A 1 236 ? -13.943 -5.603  -22.571 1.00 8.35  ? 263 THR A CA  1 
ATOM   1812 C C   . THR A 1 236 ? -12.425 -5.656  -22.565 1.00 9.26  ? 263 THR A C   1 
ATOM   1813 O O   . THR A 1 236 ? -11.777 -4.991  -21.746 1.00 9.00  ? 263 THR A O   1 
ATOM   1814 C CB  . THR A 1 236 ? -14.419 -4.150  -22.694 1.00 7.41  ? 263 THR A CB  1 
ATOM   1815 O OG1 . THR A 1 236 ? -14.017 -3.395  -21.542 1.00 9.06  ? 263 THR A OG1 1 
ATOM   1816 C CG2 . THR A 1 236 ? -15.936 -4.059  -22.801 1.00 10.11 ? 263 THR A CG2 1 
ATOM   1817 N N   . TYR A 1 237 ? -11.863 -6.434  -23.483 1.00 8.47  ? 264 TYR A N   1 
ATOM   1818 C CA  . TYR A 1 237 ? -10.428 -6.594  -23.632 1.00 8.05  ? 264 TYR A CA  1 
ATOM   1819 C C   . TYR A 1 237 ? -10.005 -5.990  -24.967 1.00 8.79  ? 264 TYR A C   1 
ATOM   1820 O O   . TYR A 1 237 ? -10.730 -6.095  -25.956 1.00 10.06 ? 264 TYR A O   1 
ATOM   1821 C CB  . TYR A 1 237 ? -10.048 -8.075  -23.575 1.00 9.73  ? 264 TYR A CB  1 
ATOM   1822 C CG  . TYR A 1 237 ? -9.984  -8.671  -22.180 1.00 8.93  ? 264 TYR A CG  1 
ATOM   1823 C CD1 . TYR A 1 237 ? -9.901  -7.862  -21.054 1.00 16.26 ? 264 TYR A CD1 1 
ATOM   1824 C CD2 . TYR A 1 237 ? -9.956  -10.046 -21.999 1.00 17.27 ? 264 TYR A CD2 1 
ATOM   1825 C CE1 . TYR A 1 237 ? -9.811  -8.414  -19.781 1.00 17.05 ? 264 TYR A CE1 1 
ATOM   1826 C CE2 . TYR A 1 237 ? -9.862  -10.602 -20.734 1.00 16.71 ? 264 TYR A CE2 1 
ATOM   1827 C CZ  . TYR A 1 237 ? -9.783  -9.777  -19.638 1.00 13.47 ? 264 TYR A CZ  1 
ATOM   1828 O OH  . TYR A 1 237 ? -9.694  -10.318 -18.368 1.00 12.99 ? 264 TYR A OH  1 
ATOM   1829 N N   . PHE A 1 238 ? -8.836  -5.359  -25.003 1.00 6.93  ? 265 PHE A N   1 
ATOM   1830 C CA  . PHE A 1 238 ? -8.405  -4.691  -26.227 1.00 7.98  ? 265 PHE A CA  1 
ATOM   1831 C C   . PHE A 1 238 ? -6.891  -4.686  -26.311 1.00 8.32  ? 265 PHE A C   1 
ATOM   1832 O O   . PHE A 1 238 ? -6.215  -4.363  -25.333 1.00 9.49  ? 265 PHE A O   1 
ATOM   1833 C CB  . PHE A 1 238 ? -8.942  -3.248  -26.278 1.00 9.73  ? 265 PHE A CB  1 
ATOM   1834 C CG  . PHE A 1 238 ? -8.596  -2.516  -27.554 1.00 8.66  ? 265 PHE A CG  1 
ATOM   1835 C CD1 . PHE A 1 238 ? -9.133  -2.922  -28.776 1.00 9.58  ? 265 PHE A CD1 1 
ATOM   1836 C CD2 . PHE A 1 238 ? -7.755  -1.410  -27.534 1.00 9.16  ? 265 PHE A CD2 1 
ATOM   1837 C CE1 . PHE A 1 238 ? -8.822  -2.245  -29.948 1.00 11.96 ? 265 PHE A CE1 1 
ATOM   1838 C CE2 . PHE A 1 238 ? -7.446  -0.724  -28.710 1.00 13.29 ? 265 PHE A CE2 1 
ATOM   1839 C CZ  . PHE A 1 238 ? -7.985  -1.144  -29.915 1.00 11.01 ? 265 PHE A CZ  1 
ATOM   1840 N N   . THR A 1 239 ? -6.360  -5.020  -27.485 1.00 9.05  ? 266 THR A N   1 
ATOM   1841 C CA  . THR A 1 239 ? -4.912  -4.991  -27.662 1.00 8.24  ? 266 THR A CA  1 
ATOM   1842 C C   . THR A 1 239 ? -4.594  -4.596  -29.106 1.00 8.22  ? 266 THR A C   1 
ATOM   1843 O O   . THR A 1 239 ? -5.449  -4.659  -29.988 1.00 10.67 ? 266 THR A O   1 
ATOM   1844 C CB  . THR A 1 239 ? -4.294  -6.336  -27.229 1.00 9.59  ? 266 THR A CB  1 
ATOM   1845 O OG1 . THR A 1 239 ? -2.876  -6.198  -27.101 1.00 11.04 ? 266 THR A OG1 1 
ATOM   1846 C CG2 . THR A 1 239 ? -4.605  -7.437  -28.225 1.00 11.38 ? 266 THR A CG2 1 
ATOM   1847 N N   . GLN A 1 240 ? -3.372  -4.132  -29.338 1.00 9.76  ? 267 GLN A N   1 
ATOM   1848 C CA  . GLN A 1 240 ? -3.050  -3.403  -30.556 1.00 11.77 ? 267 GLN A CA  1 
ATOM   1849 C C   . GLN A 1 240 ? -1.791  -3.953  -31.201 1.00 14.36 ? 267 GLN A C   1 
ATOM   1850 O O   . GLN A 1 240 ? -1.044  -4.719  -30.586 1.00 14.13 ? 267 GLN A O   1 
ATOM   1851 C CB  . GLN A 1 240 ? -2.911  -1.901  -30.242 1.00 11.58 ? 267 GLN A CB  1 
ATOM   1852 C CG  . GLN A 1 240 ? -4.156  -1.302  -29.575 1.00 9.11  ? 267 GLN A CG  1 
ATOM   1853 C CD  . GLN A 1 240 ? -4.006  0.167   -29.336 1.00 13.22 ? 267 GLN A CD  1 
ATOM   1854 O OE1 . GLN A 1 240 ? -3.938  0.949   -30.288 1.00 14.68 ? 267 GLN A OE1 1 
ATOM   1855 N NE2 . GLN A 1 240 ? -3.907  0.559   -28.066 1.00 11.03 ? 267 GLN A NE2 1 
ATOM   1856 N N   . PRO A 1 241 ? -1.542  -3.614  -32.485 1.00 13.22 ? 268 PRO A N   1 
ATOM   1857 C CA  . PRO A 1 241 ? -0.435  -4.263  -33.203 1.00 17.06 ? 268 PRO A CA  1 
ATOM   1858 C C   . PRO A 1 241 ? 0.961   -3.795  -32.821 1.00 12.53 ? 268 PRO A C   1 
ATOM   1859 O O   . PRO A 1 241 ? 1.918   -4.557  -32.989 1.00 15.98 ? 268 PRO A O   1 
ATOM   1860 C CB  . PRO A 1 241 ? -0.727  -3.939  -34.677 1.00 19.88 ? 268 PRO A CB  1 
ATOM   1861 C CG  . PRO A 1 241 ? -2.104  -3.401  -34.736 1.00 17.06 ? 268 PRO A CG  1 
ATOM   1862 C CD  . PRO A 1 241 ? -2.461  -2.893  -33.387 1.00 15.68 ? 268 PRO A CD  1 
ATOM   1863 N N   A GLN A 1 242 ? 1.099   -2.583  -32.295 0.59 13.41 ? 269 GLN A N   1 
ATOM   1864 N N   B GLN A 1 242 ? 1.116   -2.566  -32.339 0.41 13.47 ? 269 GLN A N   1 
ATOM   1865 C CA  A GLN A 1 242 ? 2.396   -1.977  -32.025 0.59 14.66 ? 269 GLN A CA  1 
ATOM   1866 C CA  B GLN A 1 242 ? 2.439   -2.022  -32.056 0.41 14.65 ? 269 GLN A CA  1 
ATOM   1867 C C   A GLN A 1 242 ? 2.753   -2.135  -30.551 0.59 15.49 ? 269 GLN A C   1 
ATOM   1868 C C   B GLN A 1 242 ? 2.756   -2.156  -30.572 0.41 15.45 ? 269 GLN A C   1 
ATOM   1869 O O   A GLN A 1 242 ? 1.945   -1.797  -29.679 0.59 14.76 ? 269 GLN A O   1 
ATOM   1870 O O   B GLN A 1 242 ? 1.921   -1.830  -29.722 0.41 14.80 ? 269 GLN A O   1 
ATOM   1871 C CB  A GLN A 1 242 ? 2.370   -0.496  -32.411 0.59 17.24 ? 269 GLN A CB  1 
ATOM   1872 C CB  B GLN A 1 242 ? 2.541   -0.560  -32.491 0.41 17.22 ? 269 GLN A CB  1 
ATOM   1873 C CG  A GLN A 1 242 ? 1.727   -0.199  -33.769 0.59 23.27 ? 269 GLN A CG  1 
ATOM   1874 C CG  B GLN A 1 242 ? 2.440   -0.359  -33.994 0.41 17.35 ? 269 GLN A CG  1 
ATOM   1875 C CD  A GLN A 1 242 ? 0.203   -0.080  -33.744 0.59 23.58 ? 269 GLN A CD  1 
ATOM   1876 C CD  B GLN A 1 242 ? 3.508   -1.114  -34.758 0.41 21.41 ? 269 GLN A CD  1 
ATOM   1877 O OE1 A GLN A 1 242 ? -0.436  -0.132  -32.690 0.59 13.43 ? 269 GLN A OE1 1 
ATOM   1878 O OE1 B GLN A 1 242 ? 4.665   -1.173  -34.338 0.41 27.58 ? 269 GLN A OE1 1 
ATOM   1879 N NE2 A GLN A 1 242 ? -0.385  0.079   -34.927 0.59 24.99 ? 269 GLN A NE2 1 
ATOM   1880 N NE2 B GLN A 1 242 ? 3.122   -1.706  -35.883 0.41 25.41 ? 269 GLN A NE2 1 
ATOM   1881 N N   . GLN A 1 243 ? 3.974   -2.618  -30.275 1.00 16.08 ? 270 GLN A N   1 
ATOM   1882 C CA  . GLN A 1 243 ? 4.385   -2.861  -28.887 1.00 13.51 ? 270 GLN A CA  1 
ATOM   1883 C C   . GLN A 1 243 ? 4.235   -1.630  -27.996 1.00 13.63 ? 270 GLN A C   1 
ATOM   1884 O O   . GLN A 1 243 ? 3.885   -1.750  -26.814 1.00 16.08 ? 270 GLN A O   1 
ATOM   1885 C CB  . GLN A 1 243 ? 5.833   -3.348  -28.845 1.00 19.39 ? 270 GLN A CB  1 
ATOM   1886 C CG  . GLN A 1 243 ? 6.291   -3.772  -27.455 1.00 17.12 ? 270 GLN A CG  1 
ATOM   1887 C CD  . GLN A 1 243 ? 7.679   -4.366  -27.472 1.00 26.08 ? 270 GLN A CD  1 
ATOM   1888 O OE1 . GLN A 1 243 ? 8.565   -3.871  -28.170 1.00 27.71 ? 270 GLN A OE1 1 
ATOM   1889 N NE2 . GLN A 1 243 ? 7.883   -5.420  -26.696 1.00 26.32 ? 270 GLN A NE2 1 
ATOM   1890 N N   A ASN A 1 244 ? 4.521   -0.443  -28.517 0.48 15.84 ? 271 ASN A N   1 
ATOM   1891 N N   B ASN A 1 244 ? 4.503   -0.440  -28.541 0.52 15.82 ? 271 ASN A N   1 
ATOM   1892 C CA  A ASN A 1 244 ? 4.455   0.759   -27.697 0.48 15.44 ? 271 ASN A CA  1 
ATOM   1893 C CA  B ASN A 1 244 ? 4.496   0.799   -27.773 0.52 15.50 ? 271 ASN A CA  1 
ATOM   1894 C C   A ASN A 1 244 ? 3.234   1.610   -28.033 0.48 15.32 ? 271 ASN A C   1 
ATOM   1895 C C   B ASN A 1 244 ? 3.211   1.598   -27.956 0.52 15.38 ? 271 ASN A C   1 
ATOM   1896 O O   A ASN A 1 244 ? 3.260   2.839   -27.905 0.48 16.82 ? 271 ASN A O   1 
ATOM   1897 O O   B ASN A 1 244 ? 3.188   2.801   -27.658 0.52 15.77 ? 271 ASN A O   1 
ATOM   1898 C CB  A ASN A 1 244 ? 5.755   1.554   -27.817 0.48 21.49 ? 271 ASN A CB  1 
ATOM   1899 C CB  B ASN A 1 244 ? 5.704   1.664   -28.146 0.52 20.49 ? 271 ASN A CB  1 
ATOM   1900 C CG  A ASN A 1 244 ? 6.915   0.866   -27.108 0.48 20.36 ? 271 ASN A CG  1 
ATOM   1901 C CG  B ASN A 1 244 ? 5.914   1.763   -29.645 0.52 25.11 ? 271 ASN A CG  1 
ATOM   1902 O OD1 A ASN A 1 244 ? 6.748   0.300   -26.022 0.48 19.23 ? 271 ASN A OD1 1 
ATOM   1903 O OD1 B ASN A 1 244 ? 4.959   1.863   -30.417 0.52 22.46 ? 271 ASN A OD1 1 
ATOM   1904 N ND2 A ASN A 1 244 ? 8.092   0.905   -27.721 0.48 25.68 ? 271 ASN A ND2 1 
ATOM   1905 N ND2 B ASN A 1 244 ? 7.175   1.746   -30.065 0.52 31.61 ? 271 ASN A ND2 1 
ATOM   1906 N N   . ALA A 1 245 ? 2.142   0.955   -28.423 1.00 14.16 ? 272 ALA A N   1 
ATOM   1907 C CA  . ALA A 1 245 ? 0.896   1.658   -28.691 1.00 12.83 ? 272 ALA A CA  1 
ATOM   1908 C C   . ALA A 1 245 ? 0.354   2.338   -27.437 1.00 15.69 ? 272 ALA A C   1 
ATOM   1909 O O   . ALA A 1 245 ? 0.588   1.898   -26.308 1.00 16.59 ? 272 ALA A O   1 
ATOM   1910 C CB  . ALA A 1 245 ? -0.160  0.693   -29.242 1.00 13.86 ? 272 ALA A CB  1 
ATOM   1911 N N   . GLU A 1 246 ? -0.380  3.425   -27.663 1.00 17.37 ? 273 GLU A N   1 
ATOM   1912 C CA  . GLU A 1 246 ? -1.023  4.188   -26.608 1.00 17.74 ? 273 GLU A CA  1 
ATOM   1913 C C   . GLU A 1 246 ? -2.244  3.439   -26.072 1.00 14.71 ? 273 GLU A C   1 
ATOM   1914 O O   . GLU A 1 246 ? -2.847  2.612   -26.756 1.00 15.38 ? 273 GLU A O   1 
ATOM   1915 C CB  . GLU A 1 246 ? -1.481  5.544   -27.149 1.00 21.13 ? 273 GLU A CB  1 
ATOM   1916 C CG  . GLU A 1 246 ? -2.831  5.446   -27.870 1.00 28.42 ? 273 GLU A CG  1 
ATOM   1917 C CD  . GLU A 1 246 ? -2.951  6.316   -29.101 1.00 38.94 ? 273 GLU A CD  1 
ATOM   1918 O OE1 . GLU A 1 246 ? -3.075  7.547   -28.945 1.00 38.08 ? 273 GLU A OE1 1 
ATOM   1919 O OE2 . GLU A 1 246 ? -2.949  5.760   -30.224 1.00 42.40 ? 273 GLU A OE2 1 
ATOM   1920 N N   A SER A 1 247 ? -2.608  3.748   -24.830 0.70 14.57 ? 274 SER A N   1 
ATOM   1921 N N   B SER A 1 247 ? -2.611  3.758   -24.834 0.30 14.64 ? 274 SER A N   1 
ATOM   1922 C CA  A SER A 1 247 ? -3.825  3.188   -24.257 0.70 14.24 ? 274 SER A CA  1 
ATOM   1923 C CA  B SER A 1 247 ? -3.829  3.211   -24.253 0.30 14.28 ? 274 SER A CA  1 
ATOM   1924 C C   A SER A 1 247 ? -5.058  3.754   -24.954 0.70 13.31 ? 274 SER A C   1 
ATOM   1925 C C   B SER A 1 247 ? -5.056  3.751   -24.978 0.30 13.35 ? 274 SER A C   1 
ATOM   1926 O O   A SER A 1 247 ? -5.060  4.885   -25.449 0.70 14.67 ? 274 SER A O   1 
ATOM   1927 O O   B SER A 1 247 ? -5.050  4.863   -25.515 0.30 14.69 ? 274 SER A O   1 
ATOM   1928 C CB  A SER A 1 247 ? -3.898  3.473   -22.756 0.70 17.55 ? 274 SER A CB  1 
ATOM   1929 C CB  B SER A 1 247 ? -3.915  3.557   -22.768 0.30 17.54 ? 274 SER A CB  1 
ATOM   1930 O OG  A SER A 1 247 ? -2.973  2.678   -22.032 0.70 20.66 ? 274 SER A OG  1 
ATOM   1931 O OG  B SER A 1 247 ? -4.041  4.957   -22.588 0.30 18.42 ? 274 SER A OG  1 
ATOM   1932 N N   . ARG A 1 248 ? -6.123  2.952   -24.987 1.00 11.59 ? 275 ARG A N   1 
ATOM   1933 C CA  . ARG A 1 248 ? -7.364  3.321   -25.670 1.00 9.58  ? 275 ARG A CA  1 
ATOM   1934 C C   . ARG A 1 248 ? -8.579  2.990   -24.798 1.00 11.51 ? 275 ARG A C   1 
ATOM   1935 O O   . ARG A 1 248 ? -9.449  2.208   -25.166 1.00 10.24 ? 275 ARG A O   1 
ATOM   1936 C CB  . ARG A 1 248 ? -7.462  2.633   -27.031 1.00 8.60  ? 275 ARG A CB  1 
ATOM   1937 C CG  . ARG A 1 248 ? -6.431  3.143   -28.052 1.00 11.90 ? 275 ARG A CG  1 
ATOM   1938 C CD  . ARG A 1 248 ? -6.691  4.605   -28.439 1.00 12.13 ? 275 ARG A CD  1 
ATOM   1939 N NE  . ARG A 1 248 ? -8.036  4.823   -28.967 1.00 12.37 ? 275 ARG A NE  1 
ATOM   1940 C CZ  . ARG A 1 248 ? -8.393  4.673   -30.237 1.00 12.65 ? 275 ARG A CZ  1 
ATOM   1941 N NH1 . ARG A 1 248 ? -7.541  4.246   -31.153 1.00 14.80 ? 275 ARG A NH1 1 
ATOM   1942 N NH2 . ARG A 1 248 ? -9.645  4.955   -30.597 1.00 13.09 ? 275 ARG A NH2 1 
ATOM   1943 N N   A ARG A 1 249 ? -8.648  3.620   -23.626 0.45 10.04 ? 276 ARG A N   1 
ATOM   1944 N N   B ARG A 1 249 ? -8.651  3.614   -23.618 0.55 10.03 ? 276 ARG A N   1 
ATOM   1945 C CA  A ARG A 1 249 ? -9.788  3.382   -22.746 0.45 9.48  ? 276 ARG A CA  1 
ATOM   1946 C CA  B ARG A 1 249 ? -9.797  3.388   -22.738 0.55 9.45  ? 276 ARG A CA  1 
ATOM   1947 C C   A ARG A 1 249 ? -11.097 3.824   -23.388 0.45 10.46 ? 276 ARG A C   1 
ATOM   1948 C C   B ARG A 1 249 ? -11.102 3.808   -23.405 0.55 10.45 ? 276 ARG A C   1 
ATOM   1949 O O   A ARG A 1 249 ? -12.160 3.292   -23.043 0.45 10.66 ? 276 ARG A O   1 
ATOM   1950 O O   B ARG A 1 249 ? -12.167 3.258   -23.092 0.55 10.61 ? 276 ARG A O   1 
ATOM   1951 C CB  A ARG A 1 249 ? -9.551  4.083   -21.402 0.45 10.19 ? 276 ARG A CB  1 
ATOM   1952 C CB  B ARG A 1 249 ? -9.590  4.123   -21.406 0.55 10.15 ? 276 ARG A CB  1 
ATOM   1953 C CG  A ARG A 1 249 ? -8.274  3.592   -20.711 0.45 11.08 ? 276 ARG A CG  1 
ATOM   1954 C CG  B ARG A 1 249 ? -8.551  3.459   -20.486 0.55 11.86 ? 276 ARG A CG  1 
ATOM   1955 C CD  A ARG A 1 249 ? -8.070  4.201   -19.337 0.45 12.99 ? 276 ARG A CD  1 
ATOM   1956 C CD  B ARG A 1 249 ? -8.206  4.332   -19.275 0.55 13.10 ? 276 ARG A CD  1 
ATOM   1957 N NE  A ARG A 1 249 ? -7.737  5.615   -19.438 0.45 12.24 ? 276 ARG A NE  1 
ATOM   1958 N NE  B ARG A 1 249 ? -7.706  3.561   -18.142 0.55 24.72 ? 276 ARG A NE  1 
ATOM   1959 C CZ  A ARG A 1 249 ? -7.561  6.417   -18.397 0.45 17.83 ? 276 ARG A CZ  1 
ATOM   1960 C CZ  B ARG A 1 249 ? -7.447  4.069   -16.943 0.55 21.85 ? 276 ARG A CZ  1 
ATOM   1961 N NH1 A ARG A 1 249 ? -7.624  5.964   -17.156 0.45 22.48 ? 276 ARG A NH1 1 
ATOM   1962 N NH1 B ARG A 1 249 ? -7.544  5.368   -16.707 0.55 23.24 ? 276 ARG A NH1 1 
ATOM   1963 N NH2 A ARG A 1 249 ? -7.308  7.705   -18.606 0.45 21.82 ? 276 ARG A NH2 1 
ATOM   1964 N NH2 B ARG A 1 249 ? -7.083  3.254   -15.956 0.55 9.19  ? 276 ARG A NH2 1 
ATOM   1965 N N   . ASP A 1 250 ? -11.038 4.760   -24.341 1.00 10.31 ? 277 ASP A N   1 
ATOM   1966 C CA  . ASP A 1 250 ? -12.243 5.188   -25.053 1.00 10.84 ? 277 ASP A CA  1 
ATOM   1967 C C   . ASP A 1 250 ? -12.875 4.059   -25.855 1.00 11.90 ? 277 ASP A C   1 
ATOM   1968 O O   . ASP A 1 250 ? -14.093 4.062   -26.066 1.00 10.84 ? 277 ASP A O   1 
ATOM   1969 C CB  . ASP A 1 250 ? -11.907 6.343   -25.994 1.00 12.02 ? 277 ASP A CB  1 
ATOM   1970 C CG  . ASP A 1 250 ? -10.981 5.910   -27.134 1.00 18.83 ? 277 ASP A CG  1 
ATOM   1971 O OD1 . ASP A 1 250 ? -9.820  5.544   -26.856 1.00 15.02 ? 277 ASP A OD1 1 
ATOM   1972 O OD2 . ASP A 1 250 ? -11.417 5.923   -28.308 1.00 23.65 ? 277 ASP A OD2 1 
ATOM   1973 N N   . VAL A 1 251 ? -12.069 3.112   -26.340 1.00 12.39 ? 278 VAL A N   1 
ATOM   1974 C CA  . VAL A 1 251 ? -12.618 1.972   -27.067 1.00 11.63 ? 278 VAL A CA  1 
ATOM   1975 C C   . VAL A 1 251 ? -13.447 1.099   -26.133 1.00 8.13  ? 278 VAL A C   1 
ATOM   1976 O O   . VAL A 1 251 ? -14.512 0.588   -26.508 1.00 9.70  ? 278 VAL A O   1 
ATOM   1977 C CB  . VAL A 1 251 ? -11.481 1.181   -27.735 1.00 10.04 ? 278 VAL A CB  1 
ATOM   1978 C CG1 . VAL A 1 251 ? -11.990 -0.147  -28.312 1.00 10.31 ? 278 VAL A CG1 1 
ATOM   1979 C CG2 . VAL A 1 251 ? -10.810 2.032   -28.812 1.00 12.84 ? 278 VAL A CG2 1 
ATOM   1980 N N   . LEU A 1 252 ? -12.986 0.932   -24.891 1.00 9.65  ? 279 LEU A N   1 
ATOM   1981 C CA  . LEU A 1 252 ? -13.767 0.170   -23.922 1.00 9.84  ? 279 LEU A CA  1 
ATOM   1982 C C   . LEU A 1 252 ? -15.074 0.877   -23.588 1.00 10.62 ? 279 LEU A C   1 
ATOM   1983 O O   . LEU A 1 252 ? -16.129 0.239   -23.500 1.00 10.76 ? 279 LEU A O   1 
ATOM   1984 C CB  . LEU A 1 252 ? -12.953 -0.063  -22.646 1.00 9.44  ? 279 LEU A CB  1 
ATOM   1985 C CG  . LEU A 1 252 ? -11.533 -0.610  -22.842 1.00 8.44  ? 279 LEU A CG  1 
ATOM   1986 C CD1 . LEU A 1 252 ? -10.911 -0.903  -21.481 1.00 8.97  ? 279 LEU A CD1 1 
ATOM   1987 C CD2 . LEU A 1 252 ? -11.511 -1.867  -23.727 1.00 9.78  ? 279 LEU A CD2 1 
ATOM   1988 N N   . ALA A 1 253 ? -15.023 2.204   -23.406 1.00 9.88  ? 280 ALA A N   1 
ATOM   1989 C CA  . ALA A 1 253 ? -16.245 2.958   -23.171 1.00 8.60  ? 280 ALA A CA  1 
ATOM   1990 C C   . ALA A 1 253 ? -17.196 2.849   -24.358 1.00 9.04  ? 280 ALA A C   1 
ATOM   1991 O O   . ALA A 1 253 ? -18.412 2.713   -24.178 1.00 10.05 ? 280 ALA A O   1 
ATOM   1992 C CB  . ALA A 1 253 ? -15.901 4.423   -22.896 1.00 10.26 ? 280 ALA A CB  1 
ATOM   1993 N N   A SER A 1 254 ? -16.655 2.898   -25.576 0.78 10.71 ? 281 SER A N   1 
ATOM   1994 N N   B SER A 1 254 ? -16.657 2.897   -25.578 0.22 10.73 ? 281 SER A N   1 
ATOM   1995 C CA  A SER A 1 254 ? -17.491 2.786   -26.769 0.78 11.83 ? 281 SER A CA  1 
ATOM   1996 C CA  B SER A 1 254 ? -17.500 2.785   -26.764 0.22 11.79 ? 281 SER A CA  1 
ATOM   1997 C C   A SER A 1 254 ? -18.141 1.414   -26.870 0.78 11.98 ? 281 SER A C   1 
ATOM   1998 C C   B SER A 1 254 ? -18.147 1.410   -26.857 0.22 11.93 ? 281 SER A C   1 
ATOM   1999 O O   A SER A 1 254 ? -19.305 1.303   -27.279 0.78 11.80 ? 281 SER A O   1 
ATOM   2000 O O   B SER A 1 254 ? -19.318 1.295   -27.239 0.22 11.84 ? 281 SER A O   1 
ATOM   2001 C CB  A SER A 1 254 ? -16.659 3.062   -28.020 0.78 9.42  ? 281 SER A CB  1 
ATOM   2002 C CB  B SER A 1 254 ? -16.682 3.069   -28.020 0.22 9.58  ? 281 SER A CB  1 
ATOM   2003 O OG  A SER A 1 254 ? -16.397 4.452   -28.159 0.78 13.96 ? 281 SER A OG  1 
ATOM   2004 O OG  B SER A 1 254 ? -17.482 2.918   -29.178 0.22 10.12 ? 281 SER A OG  1 
ATOM   2005 N N   . ALA A 1 255 ? -17.397 0.354   -26.531 1.00 10.81 ? 282 ALA A N   1 
ATOM   2006 C CA  . ALA A 1 255 ? -17.981 -0.987  -26.507 1.00 12.62 ? 282 ALA A CA  1 
ATOM   2007 C C   . ALA A 1 255 ? -19.103 -1.076  -25.479 1.00 10.33 ? 282 ALA A C   1 
ATOM   2008 O O   . ALA A 1 255 ? -20.175 -1.628  -25.759 1.00 11.79 ? 282 ALA A O   1 
ATOM   2009 C CB  . ALA A 1 255 ? -16.906 -2.035  -26.211 1.00 11.77 ? 282 ALA A CB  1 
ATOM   2010 N N   . ALA A 1 256 ? -18.875 -0.539  -24.275 1.00 9.06  ? 283 ALA A N   1 
ATOM   2011 C CA  . ALA A 1 256 ? -19.915 -0.568  -23.249 1.00 9.92  ? 283 ALA A CA  1 
ATOM   2012 C C   . ALA A 1 256 ? -21.149 0.203   -23.696 1.00 10.95 ? 283 ALA A C   1 
ATOM   2013 O O   . ALA A 1 256 ? -22.280 -0.222  -23.434 1.00 14.38 ? 283 ALA A O   1 
ATOM   2014 C CB  . ALA A 1 256 ? -19.378 0.012   -21.940 1.00 10.47 ? 283 ALA A CB  1 
ATOM   2015 N N   . ARG A 1 257 ? -20.948 1.326   -24.395 1.00 9.77  ? 284 ARG A N   1 
ATOM   2016 C CA  . ARG A 1 257 ? -22.073 2.148   -24.827 1.00 12.25 ? 284 ARG A CA  1 
ATOM   2017 C C   . ARG A 1 257 ? -22.903 1.413   -25.872 1.00 13.81 ? 284 ARG A C   1 
ATOM   2018 O O   . ARG A 1 257 ? -24.139 1.461   -25.839 1.00 13.50 ? 284 ARG A O   1 
ATOM   2019 C CB  . ARG A 1 257 ? -21.543 3.484   -25.359 1.00 14.39 ? 284 ARG A CB  1 
ATOM   2020 C CG  . ARG A 1 257 ? -22.599 4.476   -25.832 1.00 16.50 ? 284 ARG A CG  1 
ATOM   2021 C CD  . ARG A 1 257 ? -21.930 5.810   -26.205 1.00 24.49 ? 284 ARG A CD  1 
ATOM   2022 N NE  . ARG A 1 257 ? -21.123 6.360   -25.114 1.00 23.79 ? 284 ARG A NE  1 
ATOM   2023 C CZ  . ARG A 1 257 ? -19.801 6.487   -25.130 1.00 34.56 ? 284 ARG A CZ  1 
ATOM   2024 N NH1 . ARG A 1 257 ? -19.077 6.104   -26.172 1.00 24.42 ? 284 ARG A NH1 1 
ATOM   2025 N NH2 . ARG A 1 257 ? -19.187 7.002   -24.068 1.00 29.86 ? 284 ARG A NH2 1 
ATOM   2026 N N   . ILE A 1 258 ? -22.239 0.694   -26.781 1.00 12.42 ? 285 ILE A N   1 
ATOM   2027 C CA  . ILE A 1 258 ? -22.949 -0.138  -27.750 1.00 11.42 ? 285 ILE A CA  1 
ATOM   2028 C C   . ILE A 1 258 ? -23.769 -1.204  -27.039 1.00 15.57 ? 285 ILE A C   1 
ATOM   2029 O O   . ILE A 1 258 ? -24.938 -1.442  -27.367 1.00 16.41 ? 285 ILE A O   1 
ATOM   2030 C CB  . ILE A 1 258 ? -21.948 -0.767  -28.732 1.00 11.42 ? 285 ILE A CB  1 
ATOM   2031 C CG1 . ILE A 1 258 ? -21.425 0.287   -29.704 1.00 13.94 ? 285 ILE A CG1 1 
ATOM   2032 C CG2 . ILE A 1 258 ? -22.581 -1.971  -29.456 1.00 16.10 ? 285 ILE A CG2 1 
ATOM   2033 C CD1 . ILE A 1 258 ? -20.127 -0.111  -30.375 1.00 13.77 ? 285 ILE A CD1 1 
ATOM   2034 N N   . ILE A 1 259 ? -23.161 -1.863  -26.056 1.00 16.15 ? 286 ILE A N   1 
ATOM   2035 C CA  . ILE A 1 259 ? -23.843 -2.917  -25.317 1.00 20.85 ? 286 ILE A CA  1 
ATOM   2036 C C   . ILE A 1 259 ? -25.057 -2.356  -24.587 1.00 17.73 ? 286 ILE A C   1 
ATOM   2037 O O   . ILE A 1 259 ? -26.131 -2.975  -24.565 1.00 22.41 ? 286 ILE A O   1 
ATOM   2038 C CB  . ILE A 1 259 ? -22.845 -3.596  -24.357 1.00 17.72 ? 286 ILE A CB  1 
ATOM   2039 C CG1 . ILE A 1 259 ? -21.855 -4.455  -25.151 1.00 25.59 ? 286 ILE A CG1 1 
ATOM   2040 C CG2 . ILE A 1 259 ? -23.569 -4.405  -23.291 1.00 26.94 ? 286 ILE A CG2 1 
ATOM   2041 C CD1 . ILE A 1 259 ? -22.443 -5.745  -25.680 1.00 23.94 ? 286 ILE A CD1 1 
ATOM   2042 N N   . ALA A 1 260 ? -24.917 -1.160  -23.997 1.00 15.69 ? 287 ALA A N   1 
ATOM   2043 C CA  . ALA A 1 260 ? -26.029 -0.572  -23.253 1.00 20.90 ? 287 ALA A CA  1 
ATOM   2044 C C   . ALA A 1 260 ? -27.157 -0.120  -24.175 1.00 26.73 ? 287 ALA A C   1 
ATOM   2045 O O   . ALA A 1 260 ? -28.318 -0.093  -23.752 1.00 34.42 ? 287 ALA A O   1 
ATOM   2046 C CB  . ALA A 1 260 ? -25.538 0.601   -22.409 1.00 18.81 ? 287 ALA A CB  1 
ATOM   2047 N N   . GLU A 1 261 ? -26.838 0.250   -25.420 1.00 22.14 ? 288 GLU A N   1 
ATOM   2048 C CA  . GLU A 1 261 ? -27.877 0.562   -26.402 1.00 29.19 ? 288 GLU A CA  1 
ATOM   2049 C C   . GLU A 1 261 ? -28.700 -0.674  -26.740 1.00 37.01 ? 288 GLU A C   1 
ATOM   2050 O O   . GLU A 1 261 ? -29.932 -0.669  -26.628 1.00 40.14 ? 288 GLU A O   1 
ATOM   2051 C CB  . GLU A 1 261 ? -27.260 1.131   -27.684 1.00 24.92 ? 288 GLU A CB  1 
ATOM   2052 C CG  . GLU A 1 261 ? -26.709 2.534   -27.605 1.00 44.68 ? 288 GLU A CG  1 
ATOM   2053 C CD  . GLU A 1 261 ? -25.809 2.853   -28.791 1.00 43.87 ? 288 GLU A CD  1 
ATOM   2054 O OE1 . GLU A 1 261 ? -25.753 2.028   -29.733 1.00 39.34 ? 288 GLU A OE1 1 
ATOM   2055 O OE2 . GLU A 1 261 ? -25.157 3.922   -28.781 1.00 48.04 ? 288 GLU A OE2 1 
ATOM   2056 N N   . GLY A 1 262 ? -28.029 -1.747  -27.166 1.00 39.29 ? 289 GLY A N   1 
ATOM   2057 C CA  . GLY A 1 262 ? -28.692 -2.970  -27.580 1.00 39.00 ? 289 GLY A CA  1 
ATOM   2058 C C   . GLY A 1 262 ? -29.390 -3.674  -26.436 1.00 49.09 ? 289 GLY A C   1 
ATOM   2059 O O   . GLY A 1 262 ? -29.998 -4.736  -26.613 1.00 47.63 ? 289 GLY A O   1 
ATOM   2060 N N   . LEU A 1 263 ? -29.303 -3.077  -25.254 1.00 46.98 ? 290 LEU A N   1 
ATOM   2061 C CA  . LEU A 1 263 ? -29.935 -3.597  -24.055 1.00 48.76 ? 290 LEU A CA  1 
ATOM   2062 C C   . LEU A 1 263 ? -31.178 -2.756  -23.769 1.00 53.56 ? 290 LEU A C   1 
ATOM   2063 O O   . LEU A 1 263 ? -31.262 -2.033  -22.778 1.00 56.14 ? 290 LEU A O   1 
ATOM   2064 C CB  . LEU A 1 263 ? -28.942 -3.564  -22.889 1.00 39.93 ? 290 LEU A CB  1 
ATOM   2065 C CG  . LEU A 1 263 ? -29.313 -4.073  -21.502 1.00 40.72 ? 290 LEU A CG  1 
ATOM   2066 C CD1 . LEU A 1 263 ? -28.737 -5.460  -21.316 1.00 42.99 ? 290 LEU A CD1 1 
ATOM   2067 C CD2 . LEU A 1 263 ? -28.784 -3.129  -20.442 1.00 43.00 ? 290 LEU A CD2 1 
ATOM   2068 O OXT . LEU A 1 263 ? -32.129 -2.760  -24.554 1.00 50.46 ? 290 LEU A OXT 1 
ATOM   2069 N N   . GLN B 1 1   ? 2.349   39.295  -21.707 1.00 49.04 ? 25  GLN B N   1 
ATOM   2070 C CA  . GLN B 1 1   ? 2.311   38.435  -20.538 1.00 18.64 ? 25  GLN B CA  1 
ATOM   2071 C C   . GLN B 1 1   ? 1.425   37.232  -20.810 1.00 21.83 ? 25  GLN B C   1 
ATOM   2072 O O   . GLN B 1 1   ? 0.518   36.912  -20.033 1.00 22.75 ? 25  GLN B O   1 
ATOM   2073 C CB  . GLN B 1 1   ? 1.822   39.219  -19.323 1.00 20.41 ? 25  GLN B CB  1 
ATOM   2074 C CG  . GLN B 1 1   ? 2.759   39.161  -18.143 1.00 29.54 ? 25  GLN B CG  1 
ATOM   2075 C CD  . GLN B 1 1   ? 2.241   39.950  -16.958 1.00 50.34 ? 25  GLN B CD  1 
ATOM   2076 O OE1 . GLN B 1 1   ? 1.266   40.695  -17.077 1.00 59.54 ? 25  GLN B OE1 1 
ATOM   2077 N NE2 . GLN B 1 1   ? 2.892   39.797  -15.807 1.00 56.85 ? 25  GLN B NE2 1 
ATOM   2078 N N   . THR B 1 2   ? 1.678   36.581  -21.941 1.00 19.46 ? 26  THR B N   1 
ATOM   2079 C CA  . THR B 1 2   ? 1.026   35.331  -22.293 1.00 18.80 ? 26  THR B CA  1 
ATOM   2080 C C   . THR B 1 2   ? 2.124   34.299  -22.507 1.00 20.27 ? 26  THR B C   1 
ATOM   2081 O O   . THR B 1 2   ? 2.967   34.453  -23.398 1.00 20.25 ? 26  THR B O   1 
ATOM   2082 C CB  . THR B 1 2   ? 0.170   35.474  -23.551 1.00 18.87 ? 26  THR B CB  1 
ATOM   2083 O OG1 . THR B 1 2   ? -0.945  36.338  -23.281 1.00 28.20 ? 26  THR B OG1 1 
ATOM   2084 C CG2 . THR B 1 2   ? -0.398  34.122  -23.894 1.00 19.67 ? 26  THR B CG2 1 
ATOM   2085 N N   . SER B 1 3   ? 2.129   33.264  -21.680 1.00 16.09 ? 27  SER B N   1 
ATOM   2086 C CA  . SER B 1 3   ? 3.154   32.242  -21.749 1.00 15.19 ? 27  SER B CA  1 
ATOM   2087 C C   . SER B 1 3   ? 2.810   31.199  -22.815 1.00 15.52 ? 27  SER B C   1 
ATOM   2088 O O   . SER B 1 3   ? 1.690   31.144  -23.339 1.00 16.67 ? 27  SER B O   1 
ATOM   2089 C CB  . SER B 1 3   ? 3.316   31.576  -20.385 1.00 16.08 ? 27  SER B CB  1 
ATOM   2090 O OG  . SER B 1 3   ? 2.193   30.750  -20.118 1.00 17.02 ? 27  SER B OG  1 
ATOM   2091 N N   . ALA B 1 4   ? 3.798   30.354  -23.128 1.00 17.85 ? 28  ALA B N   1 
ATOM   2092 C CA  . ALA B 1 4   ? 3.566   29.256  -24.064 1.00 14.06 ? 28  ALA B CA  1 
ATOM   2093 C C   . ALA B 1 4   ? 2.440   28.350  -23.581 1.00 15.13 ? 28  ALA B C   1 
ATOM   2094 O O   . ALA B 1 4   ? 1.580   27.940  -24.372 1.00 13.70 ? 28  ALA B O   1 
ATOM   2095 C CB  . ALA B 1 4   ? 4.846   28.444  -24.257 1.00 20.26 ? 28  ALA B CB  1 
ATOM   2096 N N   . VAL B 1 5   ? 2.429   28.035  -22.280 1.00 13.57 ? 29  VAL B N   1 
ATOM   2097 C CA  . VAL B 1 5   ? 1.382   27.191  -21.710 1.00 14.67 ? 29  VAL B CA  1 
ATOM   2098 C C   . VAL B 1 5   ? 0.028   27.875  -21.818 1.00 9.39  ? 29  VAL B C   1 
ATOM   2099 O O   . VAL B 1 5   ? -0.979  27.245  -22.166 1.00 11.02 ? 29  VAL B O   1 
ATOM   2100 C CB  . VAL B 1 5   ? 1.721   26.839  -20.250 1.00 14.59 ? 29  VAL B CB  1 
ATOM   2101 C CG1 . VAL B 1 5   ? 0.506   26.266  -19.552 1.00 14.77 ? 29  VAL B CG1 1 
ATOM   2102 C CG2 . VAL B 1 5   ? 2.878   25.849  -20.198 1.00 17.59 ? 29  VAL B CG2 1 
ATOM   2103 N N   . GLN B 1 6   ? -0.026  29.176  -21.513 1.00 11.03 ? 30  GLN B N   1 
ATOM   2104 C CA  . GLN B 1 6   ? -1.288  29.895  -21.658 1.00 10.51 ? 30  GLN B CA  1 
ATOM   2105 C C   . GLN B 1 6   ? -1.765  29.889  -23.108 1.00 11.11 ? 30  GLN B C   1 
ATOM   2106 O O   . GLN B 1 6   ? -2.970  29.795  -23.371 1.00 12.79 ? 30  GLN B O   1 
ATOM   2107 C CB  . GLN B 1 6   ? -1.148  31.325  -21.132 1.00 14.08 ? 30  GLN B CB  1 
ATOM   2108 C CG  . GLN B 1 6   ? -1.022  31.398  -19.609 1.00 12.87 ? 30  GLN B CG  1 
ATOM   2109 C CD  . GLN B 1 6   ? -0.727  32.796  -19.120 1.00 19.96 ? 30  GLN B CD  1 
ATOM   2110 O OE1 . GLN B 1 6   ? 0.127   33.483  -19.675 1.00 18.13 ? 30  GLN B OE1 1 
ATOM   2111 N NE2 . GLN B 1 6   ? -1.413  33.218  -18.063 1.00 18.47 ? 30  GLN B NE2 1 
ATOM   2112 N N   A GLN B 1 7   ? -0.836  29.980  -24.066 0.63 11.87 ? 31  GLN B N   1 
ATOM   2113 N N   B GLN B 1 7   ? -0.835  30.001  -24.063 0.37 11.89 ? 31  GLN B N   1 
ATOM   2114 C CA  A GLN B 1 7   ? -1.234  29.943  -25.472 0.63 12.51 ? 31  GLN B CA  1 
ATOM   2115 C CA  B GLN B 1 7   ? -1.220  29.941  -25.471 0.37 12.56 ? 31  GLN B CA  1 
ATOM   2116 C C   A GLN B 1 7   ? -1.794  28.578  -25.860 0.63 10.70 ? 31  GLN B C   1 
ATOM   2117 C C   B GLN B 1 7   ? -1.817  28.585  -25.825 0.37 10.78 ? 31  GLN B C   1 
ATOM   2118 O O   A GLN B 1 7   ? -2.763  28.492  -26.626 0.63 12.49 ? 31  GLN B O   1 
ATOM   2119 O O   B GLN B 1 7   ? -2.820  28.508  -26.546 0.37 12.46 ? 31  GLN B O   1 
ATOM   2120 C CB  A GLN B 1 7   ? -0.047  30.319  -26.357 0.63 14.60 ? 31  GLN B CB  1 
ATOM   2121 C CB  B GLN B 1 7   ? -0.017  30.235  -26.363 0.37 14.61 ? 31  GLN B CB  1 
ATOM   2122 C CG  A GLN B 1 7   ? 0.291   31.785  -26.226 0.63 15.48 ? 31  GLN B CG  1 
ATOM   2123 C CG  B GLN B 1 7   ? -0.392  30.839  -27.707 0.37 16.68 ? 31  GLN B CG  1 
ATOM   2124 C CD  A GLN B 1 7   ? 1.528   32.211  -26.973 0.63 27.38 ? 31  GLN B CD  1 
ATOM   2125 C CD  B GLN B 1 7   ? 0.745   31.634  -28.329 0.37 23.53 ? 31  GLN B CD  1 
ATOM   2126 O OE1 A GLN B 1 7   ? 2.417   31.405  -27.249 0.63 29.80 ? 31  GLN B OE1 1 
ATOM   2127 O OE1 B GLN B 1 7   ? 1.397   32.434  -27.658 0.37 32.75 ? 31  GLN B OE1 1 
ATOM   2128 N NE2 A GLN B 1 7   ? 1.604   33.502  -27.288 0.63 27.59 ? 31  GLN B NE2 1 
ATOM   2129 N NE2 B GLN B 1 7   ? 0.986   31.417  -29.617 0.37 26.59 ? 31  GLN B NE2 1 
ATOM   2130 N N   . LYS B 1 8   ? -1.213  27.504  -25.328 1.00 10.09 ? 32  LYS B N   1 
ATOM   2131 C CA  . LYS B 1 8   ? -1.734  26.173  -25.621 1.00 8.83  ? 32  LYS B CA  1 
ATOM   2132 C C   . LYS B 1 8   ? -3.109  25.964  -25.001 1.00 8.37  ? 32  LYS B C   1 
ATOM   2133 O O   . LYS B 1 8   ? -3.996  25.377  -25.634 1.00 10.31 ? 32  LYS B O   1 
ATOM   2134 C CB  . LYS B 1 8   ? -0.757  25.107  -25.136 1.00 11.87 ? 32  LYS B CB  1 
ATOM   2135 C CG  . LYS B 1 8   ? 0.579   25.161  -25.869 1.00 11.85 ? 32  LYS B CG  1 
ATOM   2136 C CD  . LYS B 1 8   ? 1.545   24.132  -25.299 1.00 17.27 ? 32  LYS B CD  1 
ATOM   2137 C CE  . LYS B 1 8   ? 2.837   24.052  -26.094 1.00 30.43 ? 32  LYS B CE  1 
ATOM   2138 N NZ  . LYS B 1 8   ? 2.734   24.774  -27.387 1.00 45.57 ? 32  LYS B NZ  1 
ATOM   2139 N N   . LEU B 1 9   ? -3.318  26.466  -23.783 1.00 9.57  ? 33  LEU B N   1 
ATOM   2140 C CA  . LEU B 1 9   ? -4.642  26.351  -23.164 1.00 10.30 ? 33  LEU B CA  1 
ATOM   2141 C C   . LEU B 1 9   ? -5.688  27.129  -23.954 1.00 7.56  ? 33  LEU B C   1 
ATOM   2142 O O   . LEU B 1 9   ? -6.845  26.697  -24.074 1.00 10.38 ? 33  LEU B O   1 
ATOM   2143 C CB  . LEU B 1 9   ? -4.589  26.845  -21.715 1.00 9.72  ? 33  LEU B CB  1 
ATOM   2144 C CG  . LEU B 1 9   ? -3.770  25.961  -20.781 1.00 8.91  ? 33  LEU B CG  1 
ATOM   2145 C CD1 . LEU B 1 9   ? -3.524  26.620  -19.419 1.00 10.50 ? 33  LEU B CD1 1 
ATOM   2146 C CD2 . LEU B 1 9   ? -4.459  24.616  -20.619 1.00 9.36  ? 33  LEU B CD2 1 
ATOM   2147 N N   . ALA B 1 10  ? -5.302  28.291  -24.495 1.00 9.96  ? 34  ALA B N   1 
ATOM   2148 C CA  . ALA B 1 10  ? -6.226  29.058  -25.320 1.00 11.98 ? 34  ALA B CA  1 
ATOM   2149 C C   . ALA B 1 10  ? -6.574  28.320  -26.609 1.00 9.81  ? 34  ALA B C   1 
ATOM   2150 O O   . ALA B 1 10  ? -7.728  28.364  -27.055 1.00 11.30 ? 34  ALA B O   1 
ATOM   2151 C CB  . ALA B 1 10  ? -5.629  30.425  -25.634 1.00 11.63 ? 34  ALA B CB  1 
ATOM   2152 N N   . ALA B 1 11  ? -5.595  27.627  -27.203 1.00 10.34 ? 35  ALA B N   1 
ATOM   2153 C CA  . ALA B 1 11  ? -5.875  26.834  -28.399 1.00 10.23 ? 35  ALA B CA  1 
ATOM   2154 C C   . ALA B 1 11  ? -6.784  25.662  -28.074 1.00 12.34 ? 35  ALA B C   1 
ATOM   2155 O O   . ALA B 1 11  ? -7.703  25.340  -28.840 1.00 13.19 ? 35  ALA B O   1 
ATOM   2156 C CB  . ALA B 1 11  ? -4.570  26.334  -29.022 1.00 11.31 ? 35  ALA B CB  1 
ATOM   2157 N N   . LEU B 1 12  ? -6.555  25.022  -26.927 1.00 10.77 ? 36  LEU B N   1 
ATOM   2158 C CA  . LEU B 1 12  ? -7.447  23.958  -26.500 1.00 10.82 ? 36  LEU B CA  1 
ATOM   2159 C C   . LEU B 1 12  ? -8.861  24.495  -26.328 1.00 10.36 ? 36  LEU B C   1 
ATOM   2160 O O   . LEU B 1 12  ? -9.835  23.900  -26.805 1.00 11.45 ? 36  LEU B O   1 
ATOM   2161 C CB  . LEU B 1 12  ? -6.929  23.356  -25.198 1.00 9.63  ? 36  LEU B CB  1 
ATOM   2162 C CG  . LEU B 1 12  ? -7.909  22.474  -24.438 1.00 8.46  ? 36  LEU B CG  1 
ATOM   2163 C CD1 . LEU B 1 12  ? -8.302  21.251  -25.255 1.00 10.26 ? 36  LEU B CD1 1 
ATOM   2164 C CD2 . LEU B 1 12  ? -7.266  22.085  -23.122 1.00 10.36 ? 36  LEU B CD2 1 
ATOM   2165 N N   . GLU B 1 13  ? -8.987  25.642  -25.655 1.00 9.66  ? 37  GLU B N   1 
ATOM   2166 C CA  . GLU B 1 13  ? -10.306 26.212  -25.427 1.00 8.60  ? 37  GLU B CA  1 
ATOM   2167 C C   . GLU B 1 13  ? -10.993 26.530  -26.750 1.00 10.10 ? 37  GLU B C   1 
ATOM   2168 O O   . GLU B 1 13  ? -12.186 26.266  -26.916 1.00 10.34 ? 37  GLU B O   1 
ATOM   2169 C CB  . GLU B 1 13  ? -10.182 27.467  -24.570 1.00 8.17  ? 37  GLU B CB  1 
ATOM   2170 C CG  . GLU B 1 13  ? -11.504 28.128  -24.304 1.00 8.42  ? 37  GLU B CG  1 
ATOM   2171 C CD  . GLU B 1 13  ? -11.345 29.435  -23.558 1.00 11.66 ? 37  GLU B CD  1 
ATOM   2172 O OE1 . GLU B 1 13  ? -10.679 30.347  -24.091 1.00 10.30 ? 37  GLU B OE1 1 
ATOM   2173 O OE2 . GLU B 1 13  ? -11.876 29.548  -22.437 1.00 10.86 ? 37  GLU B OE2 1 
ATOM   2174 N N   . LYS B 1 14  ? -10.252 27.103  -27.700 1.00 11.32 ? 38  LYS B N   1 
ATOM   2175 C CA  . LYS B 1 14  ? -10.853 27.498  -28.969 1.00 12.69 ? 38  LYS B CA  1 
ATOM   2176 C C   . LYS B 1 14  ? -11.473 26.305  -29.682 1.00 13.83 ? 38  LYS B C   1 
ATOM   2177 O O   . LYS B 1 14  ? -12.555 26.419  -30.269 1.00 16.21 ? 38  LYS B O   1 
ATOM   2178 C CB  . LYS B 1 14  ? -9.805  28.165  -29.860 1.00 15.43 ? 38  LYS B CB  1 
ATOM   2179 C CG  . LYS B 1 14  ? -10.267 28.379  -31.294 1.00 21.98 ? 38  LYS B CG  1 
ATOM   2180 C CD  . LYS B 1 14  ? -9.602  29.595  -31.926 1.00 29.11 ? 38  LYS B CD  1 
ATOM   2181 C CE  . LYS B 1 14  ? -8.762  29.187  -33.134 1.00 45.41 ? 38  LYS B CE  1 
ATOM   2182 N NZ  . LYS B 1 14  ? -8.224  30.355  -33.892 1.00 42.73 ? 38  LYS B NZ  1 
ATOM   2183 N N   A SER B 1 15  ? -10.812 25.150  -29.647 0.48 12.42 ? 39  SER B N   1 
ATOM   2184 N N   B SER B 1 15  ? -10.814 25.147  -29.612 0.52 12.43 ? 39  SER B N   1 
ATOM   2185 C CA  A SER B 1 15  ? -11.377 23.988  -30.322 0.48 13.36 ? 39  SER B CA  1 
ATOM   2186 C CA  B SER B 1 15  ? -11.268 23.918  -30.253 0.52 13.61 ? 39  SER B CA  1 
ATOM   2187 C C   A SER B 1 15  ? -12.463 23.292  -29.512 0.48 13.95 ? 39  SER B C   1 
ATOM   2188 C C   B SER B 1 15  ? -12.272 23.137  -29.418 0.52 13.82 ? 39  SER B C   1 
ATOM   2189 O O   A SER B 1 15  ? -13.196 22.472  -30.076 0.48 19.54 ? 39  SER B O   1 
ATOM   2190 O O   B SER B 1 15  ? -12.743 22.082  -29.860 0.52 15.36 ? 39  SER B O   1 
ATOM   2191 C CB  A SER B 1 15  ? -10.271 22.984  -30.667 0.48 15.21 ? 39  SER B CB  1 
ATOM   2192 C CB  B SER B 1 15  ? -10.067 23.015  -30.553 0.52 15.14 ? 39  SER B CB  1 
ATOM   2193 O OG  A SER B 1 15  ? -9.643  22.484  -29.501 0.48 20.87 ? 39  SER B OG  1 
ATOM   2194 O OG  B SER B 1 15  ? -9.147  23.660  -31.409 0.52 19.80 ? 39  SER B OG  1 
ATOM   2195 N N   . SER B 1 16  ? -12.603 23.611  -28.219 1.00 12.94 ? 40  SER B N   1 
ATOM   2196 C CA  . SER B 1 16  ? -13.524 22.891  -27.345 1.00 12.66 ? 40  SER B CA  1 
ATOM   2197 C C   . SER B 1 16  ? -14.960 23.359  -27.475 1.00 14.80 ? 40  SER B C   1 
ATOM   2198 O O   . SER B 1 16  ? -15.869 22.644  -27.047 1.00 22.43 ? 40  SER B O   1 
ATOM   2199 C CB  . SER B 1 16  ? -13.115 23.072  -25.883 1.00 11.76 ? 40  SER B CB  1 
ATOM   2200 O OG  . SER B 1 16  ? -13.469 24.378  -25.431 1.00 11.58 ? 40  SER B OG  1 
ATOM   2201 N N   . GLY B 1 17  ? -15.166 24.559  -27.999 1.00 16.60 ? 41  GLY B N   1 
ATOM   2202 C CA  . GLY B 1 17  ? -16.461 25.185  -28.016 1.00 25.51 ? 41  GLY B CA  1 
ATOM   2203 C C   . GLY B 1 17  ? -16.826 25.940  -26.758 1.00 29.39 ? 41  GLY B C   1 
ATOM   2204 O O   . GLY B 1 17  ? -17.689 26.821  -26.817 1.00 25.43 ? 41  GLY B O   1 
ATOM   2205 N N   . GLY B 1 18  ? -16.181 25.653  -25.623 1.00 11.61 ? 42  GLY B N   1 
ATOM   2206 C CA  . GLY B 1 18  ? -16.612 26.170  -24.350 1.00 11.37 ? 42  GLY B CA  1 
ATOM   2207 C C   . GLY B 1 18  ? -15.642 27.163  -23.747 1.00 10.80 ? 42  GLY B C   1 
ATOM   2208 O O   . GLY B 1 18  ? -14.815 27.772  -24.438 1.00 15.48 ? 42  GLY B O   1 
ATOM   2209 N N   . ARG B 1 19  ? -15.760 27.342  -22.432 1.00 8.01  ? 43  ARG B N   1 
ATOM   2210 C CA  . ARG B 1 19  ? -14.936 28.259  -21.663 1.00 10.56 ? 43  ARG B CA  1 
ATOM   2211 C C   . ARG B 1 19  ? -14.182 27.466  -20.608 1.00 9.10  ? 43  ARG B C   1 
ATOM   2212 O O   . ARG B 1 19  ? -14.800 26.733  -19.822 1.00 8.55  ? 43  ARG B O   1 
ATOM   2213 C CB  . ARG B 1 19  ? -15.797 29.341  -21.001 1.00 9.48  ? 43  ARG B CB  1 
ATOM   2214 C CG  . ARG B 1 19  ? -14.978 30.358  -20.205 1.00 7.01  ? 43  ARG B CG  1 
ATOM   2215 C CD  . ARG B 1 19  ? -15.757 31.592  -19.777 1.00 11.07 ? 43  ARG B CD  1 
ATOM   2216 N NE  . ARG B 1 19  ? -16.884 31.277  -18.913 1.00 10.72 ? 43  ARG B NE  1 
ATOM   2217 C CZ  . ARG B 1 19  ? -16.890 31.426  -17.593 1.00 9.16  ? 43  ARG B CZ  1 
ATOM   2218 N NH1 . ARG B 1 19  ? -15.859 31.957  -16.949 1.00 10.01 ? 43  ARG B NH1 1 
ATOM   2219 N NH2 . ARG B 1 19  ? -17.944 31.000  -16.899 1.00 10.43 ? 43  ARG B NH2 1 
ATOM   2220 N N   . LEU B 1 20  ? -12.862 27.633  -20.593 1.00 9.28  ? 44  LEU B N   1 
ATOM   2221 C CA  . LEU B 1 20  ? -11.931 26.844  -19.795 1.00 7.27  ? 44  LEU B CA  1 
ATOM   2222 C C   . LEU B 1 20  ? -11.258 27.733  -18.758 1.00 9.29  ? 44  LEU B C   1 
ATOM   2223 O O   . LEU B 1 20  ? -10.813 28.838  -19.081 1.00 8.56  ? 44  LEU B O   1 
ATOM   2224 C CB  . LEU B 1 20  ? -10.872 26.207  -20.704 1.00 8.46  ? 44  LEU B CB  1 
ATOM   2225 C CG  . LEU B 1 20  ? -9.730  25.416  -20.040 1.00 7.07  ? 44  LEU B CG  1 
ATOM   2226 C CD1 . LEU B 1 20  ? -10.239 24.137  -19.379 1.00 10.15 ? 44  LEU B CD1 1 
ATOM   2227 C CD2 . LEU B 1 20  ? -8.659  25.074  -21.060 1.00 11.17 ? 44  LEU B CD2 1 
ATOM   2228 N N   . GLY B 1 21  ? -11.181 27.246  -17.516 1.00 7.94  ? 45  GLY B N   1 
ATOM   2229 C CA  . GLY B 1 21  ? -10.474 27.944  -16.459 1.00 9.16  ? 45  GLY B CA  1 
ATOM   2230 C C   . GLY B 1 21  ? -9.478  27.031  -15.782 1.00 7.31  ? 45  GLY B C   1 
ATOM   2231 O O   . GLY B 1 21  ? -9.833  25.909  -15.412 1.00 9.35  ? 45  GLY B O   1 
ATOM   2232 N N   . VAL B 1 22  ? -8.239  27.481  -15.610 1.00 8.82  ? 46  VAL B N   1 
ATOM   2233 C CA  . VAL B 1 22  ? -7.167  26.652  -15.069 1.00 9.41  ? 46  VAL B CA  1 
ATOM   2234 C C   . VAL B 1 22  ? -6.393  27.453  -14.036 1.00 10.57 ? 46  VAL B C   1 
ATOM   2235 O O   . VAL B 1 22  ? -6.074  28.627  -14.253 1.00 8.43  ? 46  VAL B O   1 
ATOM   2236 C CB  . VAL B 1 22  ? -6.215  26.155  -16.180 1.00 7.92  ? 46  VAL B CB  1 
ATOM   2237 C CG1 . VAL B 1 22  ? -5.103  25.267  -15.599 1.00 9.28  ? 46  VAL B CG1 1 
ATOM   2238 C CG2 . VAL B 1 22  ? -6.991  25.414  -17.278 1.00 7.89  ? 46  VAL B CG2 1 
ATOM   2239 N N   . ALA B 1 23  ? -6.078  26.817  -12.910 1.00 8.12  ? 47  ALA B N   1 
ATOM   2240 C CA  . ALA B 1 23  ? -5.101  27.357  -11.970 1.00 7.41  ? 47  ALA B CA  1 
ATOM   2241 C C   . ALA B 1 23  ? -4.225  26.231  -11.459 1.00 7.52  ? 47  ALA B C   1 
ATOM   2242 O O   . ALA B 1 23  ? -4.727  25.245  -10.909 1.00 9.04  ? 47  ALA B O   1 
ATOM   2243 C CB  . ALA B 1 23  ? -5.786  28.064  -10.797 1.00 9.45  ? 47  ALA B CB  1 
ATOM   2244 N N   . LEU B 1 24  ? -2.922  26.374  -11.665 1.00 6.99  ? 48  LEU B N   1 
ATOM   2245 C CA  . LEU B 1 24  ? -1.896  25.499  -11.121 1.00 8.29  ? 48  LEU B CA  1 
ATOM   2246 C C   . LEU B 1 24  ? -1.100  26.235  -10.060 1.00 10.22 ? 48  LEU B C   1 
ATOM   2247 O O   . LEU B 1 24  ? -0.741  27.400  -10.253 1.00 10.57 ? 48  LEU B O   1 
ATOM   2248 C CB  . LEU B 1 24  ? -0.923  25.041  -12.217 1.00 9.55  ? 48  LEU B CB  1 
ATOM   2249 C CG  . LEU B 1 24  ? 0.403   24.425  -11.740 1.00 8.81  ? 48  LEU B CG  1 
ATOM   2250 C CD1 . LEU B 1 24  ? 0.164   23.001  -11.271 1.00 12.71 ? 48  LEU B CD1 1 
ATOM   2251 C CD2 . LEU B 1 24  ? 1.512   24.473  -12.818 1.00 15.67 ? 48  LEU B CD2 1 
ATOM   2252 N N   . ILE B 1 25  ? -0.845  25.574  -8.933  1.00 8.74  ? 49  ILE B N   1 
ATOM   2253 C CA  . ILE B 1 25  ? 0.194   26.002  -7.996  1.00 7.80  ? 49  ILE B CA  1 
ATOM   2254 C C   . ILE B 1 25  ? 1.235   24.900  -7.937  1.00 9.70  ? 49  ILE B C   1 
ATOM   2255 O O   . ILE B 1 25  ? 0.907   23.747  -7.630  1.00 9.51  ? 49  ILE B O   1 
ATOM   2256 C CB  . ILE B 1 25  ? -0.353  26.292  -6.592  1.00 7.83  ? 49  ILE B CB  1 
ATOM   2257 C CG1 . ILE B 1 25  ? -1.482  27.323  -6.638  1.00 9.72  ? 49  ILE B CG1 1 
ATOM   2258 C CG2 . ILE B 1 25  ? 0.788   26.739  -5.672  1.00 9.70  ? 49  ILE B CG2 1 
ATOM   2259 C CD1 . ILE B 1 25  ? -2.185  27.473  -5.314  1.00 10.52 ? 49  ILE B CD1 1 
ATOM   2260 N N   . ASP B 1 26  ? 2.483   25.234  -8.260  1.00 8.49  ? 50  ASP B N   1 
ATOM   2261 C CA  . ASP B 1 26  ? 3.590   24.297  -8.114  1.00 9.55  ? 50  ASP B CA  1 
ATOM   2262 C C   . ASP B 1 26  ? 4.231   24.591  -6.764  1.00 14.23 ? 50  ASP B C   1 
ATOM   2263 O O   . ASP B 1 26  ? 4.837   25.646  -6.589  1.00 15.85 ? 50  ASP B O   1 
ATOM   2264 C CB  . ASP B 1 26  ? 4.590   24.455  -9.257  1.00 11.76 ? 50  ASP B CB  1 
ATOM   2265 C CG  . ASP B 1 26  ? 5.728   23.448  -9.185  1.00 17.49 ? 50  ASP B CG  1 
ATOM   2266 O OD1 . ASP B 1 26  ? 5.888   22.778  -8.144  1.00 20.25 ? 50  ASP B OD1 1 
ATOM   2267 O OD2 . ASP B 1 26  ? 6.468   23.336  -10.190 1.00 24.02 ? 50  ASP B OD2 1 
ATOM   2268 N N   . THR B 1 27  ? 4.084   23.681  -5.797  1.00 12.63 ? 51  THR B N   1 
ATOM   2269 C CA  . THR B 1 27  ? 4.649   23.961  -4.476  1.00 13.67 ? 51  THR B CA  1 
ATOM   2270 C C   . THR B 1 27  ? 6.162   23.759  -4.429  1.00 15.74 ? 51  THR B C   1 
ATOM   2271 O O   . THR B 1 27  ? 6.758   23.977  -3.370  1.00 29.53 ? 51  THR B O   1 
ATOM   2272 C CB  . THR B 1 27  ? 3.974   23.130  -3.376  1.00 14.07 ? 51  THR B CB  1 
ATOM   2273 O OG1 . THR B 1 27  ? 4.361   21.748  -3.472  1.00 16.16 ? 51  THR B OG1 1 
ATOM   2274 C CG2 . THR B 1 27  ? 2.460   23.250  -3.462  1.00 14.32 ? 51  THR B CG2 1 
ATOM   2275 N N   . ALA B 1 28  ? 6.792   23.397  -5.551  1.00 18.38 ? 52  ALA B N   1 
ATOM   2276 C CA  . ALA B 1 28  ? 8.256   23.371  -5.605  1.00 21.38 ? 52  ALA B CA  1 
ATOM   2277 C C   . ALA B 1 28  ? 8.834   24.777  -5.509  1.00 25.34 ? 52  ALA B C   1 
ATOM   2278 O O   . ALA B 1 28  ? 9.893   24.978  -4.904  1.00 27.95 ? 52  ALA B O   1 
ATOM   2279 C CB  . ALA B 1 28  ? 8.735   22.695  -6.892  1.00 26.13 ? 52  ALA B CB  1 
ATOM   2280 N N   . ASP B 1 29  ? 8.151   25.759  -6.105  1.00 17.02 ? 53  ASP B N   1 
ATOM   2281 C CA  . ASP B 1 29  ? 8.594   27.150  -6.101  1.00 16.46 ? 53  ASP B CA  1 
ATOM   2282 C C   . ASP B 1 29  ? 7.464   28.132  -5.811  1.00 14.98 ? 53  ASP B C   1 
ATOM   2283 O O   . ASP B 1 29  ? 7.704   29.349  -5.827  1.00 13.40 ? 53  ASP B O   1 
ATOM   2284 C CB  . ASP B 1 29  ? 9.260   27.502  -7.449  1.00 15.02 ? 53  ASP B CB  1 
ATOM   2285 C CG  . ASP B 1 29  ? 8.388   27.178  -8.650  1.00 16.48 ? 53  ASP B CG  1 
ATOM   2286 O OD1 . ASP B 1 29  ? 7.167   26.952  -8.480  1.00 17.46 ? 53  ASP B OD1 1 
ATOM   2287 O OD2 . ASP B 1 29  ? 8.929   27.148  -9.781  1.00 19.20 ? 53  ASP B OD2 1 
ATOM   2288 N N   . ASN B 1 30  ? 6.242   27.645  -5.565  1.00 12.37 ? 54  ASN B N   1 
ATOM   2289 C CA  . ASN B 1 30  ? 5.035   28.431  -5.313  1.00 12.23 ? 54  ASN B CA  1 
ATOM   2290 C C   . ASN B 1 30  ? 4.562   29.215  -6.528  1.00 10.49 ? 54  ASN B C   1 
ATOM   2291 O O   . ASN B 1 30  ? 3.668   30.076  -6.388  1.00 13.69 ? 54  ASN B O   1 
ATOM   2292 C CB  . ASN B 1 30  ? 5.206   29.386  -4.126  1.00 14.48 ? 54  ASN B CB  1 
ATOM   2293 C CG  . ASN B 1 30  ? 5.752   28.683  -2.909  1.00 21.11 ? 54  ASN B CG  1 
ATOM   2294 O OD1 . ASN B 1 30  ? 5.270   27.615  -2.535  1.00 21.17 ? 54  ASN B OD1 1 
ATOM   2295 N ND2 . ASN B 1 30  ? 6.762   29.274  -2.281  1.00 24.09 ? 54  ASN B ND2 1 
ATOM   2296 N N   . THR B 1 31  ? 5.113   28.944  -7.712  1.00 12.63 ? 55  THR B N   1 
ATOM   2297 C CA  . THR B 1 31  ? 4.682   29.652  -8.904  1.00 12.53 ? 55  THR B CA  1 
ATOM   2298 C C   . THR B 1 31  ? 3.310   29.167  -9.351  1.00 15.29 ? 55  THR B C   1 
ATOM   2299 O O   . THR B 1 31  ? 2.852   28.066  -9.017  1.00 15.37 ? 55  THR B O   1 
ATOM   2300 C CB  . THR B 1 31  ? 5.668   29.483  -10.058 1.00 16.01 ? 55  THR B CB  1 
ATOM   2301 O OG1 . THR B 1 31  ? 5.849   28.091  -10.349 1.00 20.75 ? 55  THR B OG1 1 
ATOM   2302 C CG2 . THR B 1 31  ? 6.999   30.106  -9.697  1.00 13.81 ? 55  THR B CG2 1 
ATOM   2303 N N   . GLN B 1 32  ? 2.666   30.008  -10.138 1.00 15.29 ? 56  GLN B N   1 
ATOM   2304 C CA  . GLN B 1 32  ? 1.302   29.771  -10.558 1.00 14.71 ? 56  GLN B CA  1 
ATOM   2305 C C   . GLN B 1 32  ? 1.199   29.868  -12.067 1.00 16.89 ? 56  GLN B C   1 
ATOM   2306 O O   . GLN B 1 32  ? 1.907   30.657  -12.699 1.00 20.79 ? 56  GLN B O   1 
ATOM   2307 C CB  . GLN B 1 32  ? 0.355   30.766  -9.900  1.00 14.75 ? 56  GLN B CB  1 
ATOM   2308 C CG  . GLN B 1 32  ? 0.201   30.516  -8.422  1.00 20.25 ? 56  GLN B CG  1 
ATOM   2309 C CD  . GLN B 1 32  ? -0.658  31.540  -7.747  1.00 19.24 ? 56  GLN B CD  1 
ATOM   2310 O OE1 . GLN B 1 32  ? -1.593  32.071  -8.344  1.00 20.92 ? 56  GLN B OE1 1 
ATOM   2311 N NE2 . GLN B 1 32  ? -0.378  31.797  -6.475  1.00 25.11 ? 56  GLN B NE2 1 
ATOM   2312 N N   . VAL B 1 33  ? 0.327   29.049  -12.639 1.00 11.69 ? 57  VAL B N   1 
ATOM   2313 C CA  . VAL B 1 33  ? -0.092  29.182  -14.028 1.00 12.15 ? 57  VAL B CA  1 
ATOM   2314 C C   . VAL B 1 33  ? -1.600  29.341  -14.009 1.00 12.11 ? 57  VAL B C   1 
ATOM   2315 O O   . VAL B 1 33  ? -2.307  28.501  -13.438 1.00 12.18 ? 57  VAL B O   1 
ATOM   2316 C CB  . VAL B 1 33  ? 0.316   27.973  -14.881 1.00 14.09 ? 57  VAL B CB  1 
ATOM   2317 C CG1 . VAL B 1 33  ? -0.301  28.076  -16.280 1.00 19.37 ? 57  VAL B CG1 1 
ATOM   2318 C CG2 . VAL B 1 33  ? 1.828   27.861  -14.953 1.00 23.19 ? 57  VAL B CG2 1 
ATOM   2319 N N   . LEU B 1 34  ? -2.089  30.417  -14.605 1.00 11.18 ? 59  LEU B N   1 
ATOM   2320 C CA  . LEU B 1 34  ? -3.497  30.777  -14.574 1.00 12.07 ? 59  LEU B CA  1 
ATOM   2321 C C   . LEU B 1 34  ? -4.011  30.934  -15.995 1.00 13.50 ? 59  LEU B C   1 
ATOM   2322 O O   . LEU B 1 34  ? -3.320  31.483  -16.854 1.00 14.26 ? 59  LEU B O   1 
ATOM   2323 C CB  . LEU B 1 34  ? -3.689  32.080  -13.804 1.00 14.12 ? 59  LEU B CB  1 
ATOM   2324 C CG  . LEU B 1 34  ? -3.190  32.110  -12.362 1.00 15.34 ? 59  LEU B CG  1 
ATOM   2325 C CD1 . LEU B 1 34  ? -3.434  33.471  -11.785 1.00 22.69 ? 59  LEU B CD1 1 
ATOM   2326 C CD2 . LEU B 1 34  ? -3.998  31.117  -11.581 1.00 17.66 ? 59  LEU B CD2 1 
ATOM   2327 N N   . TYR B 1 35  ? -5.211  30.430  -16.249 1.00 8.97  ? 60  TYR B N   1 
ATOM   2328 C CA  . TYR B 1 35  ? -5.908  30.696  -17.501 1.00 8.26  ? 60  TYR B CA  1 
ATOM   2329 C C   . TYR B 1 35  ? -7.348  31.004  -17.132 1.00 10.46 ? 60  TYR B C   1 
ATOM   2330 O O   . TYR B 1 35  ? -8.027  30.148  -16.559 1.00 8.21  ? 60  TYR B O   1 
ATOM   2331 C CB  . TYR B 1 35  ? -5.841  29.513  -18.476 1.00 9.81  ? 60  TYR B CB  1 
ATOM   2332 C CG  . TYR B 1 35  ? -6.473  29.869  -19.801 1.00 8.13  ? 60  TYR B CG  1 
ATOM   2333 C CD1 . TYR B 1 35  ? -5.775  30.634  -20.724 1.00 9.86  ? 60  TYR B CD1 1 
ATOM   2334 C CD2 . TYR B 1 35  ? -7.789  29.523  -20.104 1.00 8.69  ? 60  TYR B CD2 1 
ATOM   2335 C CE1 . TYR B 1 35  ? -6.348  31.019  -21.919 1.00 12.46 ? 60  TYR B CE1 1 
ATOM   2336 C CE2 . TYR B 1 35  ? -8.373  29.916  -21.296 1.00 9.07  ? 60  TYR B CE2 1 
ATOM   2337 C CZ  . TYR B 1 35  ? -7.641  30.655  -22.208 1.00 10.64 ? 60  TYR B CZ  1 
ATOM   2338 O OH  . TYR B 1 35  ? -8.215  31.043  -23.396 1.00 13.48 ? 60  TYR B OH  1 
ATOM   2339 N N   . ARG B 1 36  ? -7.803  32.225  -17.425 1.00 8.96  ? 61  ARG B N   1 
ATOM   2340 C CA  . ARG B 1 36  ? -9.072  32.725  -16.893 1.00 9.37  ? 61  ARG B CA  1 
ATOM   2341 C C   . ARG B 1 36  ? -9.136  32.523  -15.381 1.00 10.93 ? 61  ARG B C   1 
ATOM   2342 O O   . ARG B 1 36  ? -10.172 32.150  -14.820 1.00 10.33 ? 61  ARG B O   1 
ATOM   2343 C CB  . ARG B 1 36  ? -10.262 32.061  -17.587 1.00 8.01  ? 61  ARG B CB  1 
ATOM   2344 C CG  . ARG B 1 36  ? -10.287 32.295  -19.092 1.00 9.18  ? 61  ARG B CG  1 
ATOM   2345 C CD  . ARG B 1 36  ? -11.637 31.990  -19.715 1.00 11.40 ? 61  ARG B CD  1 
ATOM   2346 N NE  . ARG B 1 36  ? -11.525 32.038  -21.170 1.00 10.51 ? 61  ARG B NE  1 
ATOM   2347 C CZ  . ARG B 1 36  ? -11.470 33.160  -21.872 1.00 11.67 ? 61  ARG B CZ  1 
ATOM   2348 N NH1 . ARG B 1 36  ? -11.585 34.343  -21.290 1.00 10.86 ? 61  ARG B NH1 1 
ATOM   2349 N NH2 . ARG B 1 36  ? -11.291 33.093  -23.192 1.00 11.18 ? 61  ARG B NH2 1 
ATOM   2350 N N   . GLY B 1 37  ? -8.004  32.773  -14.715 1.00 10.48 ? 62  GLY B N   1 
ATOM   2351 C CA  . GLY B 1 37  ? -7.877  32.453  -13.300 1.00 8.24  ? 62  GLY B CA  1 
ATOM   2352 C C   . GLY B 1 37  ? -8.813  33.237  -12.400 1.00 11.59 ? 62  GLY B C   1 
ATOM   2353 O O   . GLY B 1 37  ? -9.137  32.776  -11.301 1.00 10.39 ? 62  GLY B O   1 
ATOM   2354 N N   . ASP B 1 38  ? -9.269  34.403  -12.841 1.00 10.95 ? 63  ASP B N   1 
ATOM   2355 C CA  . ASP B 1 38  ? -10.111 35.253  -12.018 1.00 9.98  ? 63  ASP B CA  1 
ATOM   2356 C C   . ASP B 1 38  ? -11.537 35.350  -12.545 1.00 10.04 ? 63  ASP B C   1 
ATOM   2357 O O   . ASP B 1 38  ? -12.304 36.202  -12.090 1.00 12.82 ? 63  ASP B O   1 
ATOM   2358 C CB  . ASP B 1 38  ? -9.478  36.642  -11.890 1.00 11.15 ? 63  ASP B CB  1 
ATOM   2359 C CG  . ASP B 1 38  ? -8.166  36.601  -11.152 1.00 19.83 ? 63  ASP B CG  1 
ATOM   2360 O OD1 . ASP B 1 38  ? -8.135  36.073  -10.015 1.00 14.48 ? 63  ASP B OD1 1 
ATOM   2361 O OD2 . ASP B 1 38  ? -7.156  37.071  -11.725 1.00 21.65 ? 63  ASP B OD2 1 
ATOM   2362 N N   . GLU B 1 39  ? -11.910 34.493  -13.490 1.00 8.21  ? 64  GLU B N   1 
ATOM   2363 C CA  . GLU B 1 39  ? -13.291 34.406  -13.945 1.00 8.15  ? 64  GLU B CA  1 
ATOM   2364 C C   . GLU B 1 39  ? -14.048 33.392  -13.093 1.00 8.98  ? 64  GLU B C   1 
ATOM   2365 O O   . GLU B 1 39  ? -13.487 32.382  -12.656 1.00 10.17 ? 64  GLU B O   1 
ATOM   2366 C CB  . GLU B 1 39  ? -13.352 33.995  -15.416 1.00 10.99 ? 64  GLU B CB  1 
ATOM   2367 C CG  . GLU B 1 39  ? -12.655 34.961  -16.358 1.00 9.22  ? 64  GLU B CG  1 
ATOM   2368 C CD  . GLU B 1 39  ? -12.948 34.662  -17.820 1.00 9.03  ? 64  GLU B CD  1 
ATOM   2369 O OE1 . GLU B 1 39  ? -13.972 33.993  -18.094 1.00 12.41 ? 64  GLU B OE1 1 
ATOM   2370 O OE2 . GLU B 1 39  ? -12.144 35.093  -18.685 1.00 12.38 ? 64  GLU B OE2 1 
ATOM   2371 N N   . ARG B 1 40  ? -15.337 33.653  -12.875 1.00 8.86  ? 65  ARG B N   1 
ATOM   2372 C CA  . ARG B 1 40  ? -16.149 32.736  -12.078 1.00 8.92  ? 65  ARG B CA  1 
ATOM   2373 C C   . ARG B 1 40  ? -16.637 31.572  -12.926 1.00 9.15  ? 65  ARG B C   1 
ATOM   2374 O O   . ARG B 1 40  ? -16.948 31.729  -14.111 1.00 9.79  ? 65  ARG B O   1 
ATOM   2375 C CB  . ARG B 1 40  ? -17.349 33.456  -11.459 1.00 10.07 ? 65  ARG B CB  1 
ATOM   2376 C CG  . ARG B 1 40  ? -16.956 34.229  -10.215 1.00 15.47 ? 65  ARG B CG  1 
ATOM   2377 C CD  . ARG B 1 40  ? -18.123 34.822  -9.474  1.00 13.11 ? 65  ARG B CD  1 
ATOM   2378 N NE  . ARG B 1 40  ? -17.639 35.518  -8.284  1.00 16.08 ? 65  ARG B NE  1 
ATOM   2379 C CZ  . ARG B 1 40  ? -17.379 34.942  -7.117  1.00 15.47 ? 65  ARG B CZ  1 
ATOM   2380 N NH1 . ARG B 1 40  ? -17.647 33.663  -6.898  1.00 11.13 ? 65  ARG B NH1 1 
ATOM   2381 N NH2 . ARG B 1 40  ? -16.845 35.672  -6.140  1.00 14.42 ? 65  ARG B NH2 1 
ATOM   2382 N N   . PHE B 1 41  ? -16.708 30.397  -12.308 1.00 9.21  ? 66  PHE B N   1 
ATOM   2383 C CA  . PHE B 1 41  ? -17.225 29.178  -12.911 1.00 9.02  ? 66  PHE B CA  1 
ATOM   2384 C C   . PHE B 1 41  ? -18.144 28.494  -11.908 1.00 7.99  ? 66  PHE B C   1 
ATOM   2385 O O   . PHE B 1 41  ? -17.912 28.587  -10.697 1.00 9.58  ? 66  PHE B O   1 
ATOM   2386 C CB  . PHE B 1 41  ? -16.100 28.196  -13.290 1.00 8.47  ? 66  PHE B CB  1 
ATOM   2387 C CG  . PHE B 1 41  ? -15.209 28.659  -14.410 1.00 6.69  ? 66  PHE B CG  1 
ATOM   2388 C CD1 . PHE B 1 41  ? -14.201 29.591  -14.180 1.00 9.72  ? 66  PHE B CD1 1 
ATOM   2389 C CD2 . PHE B 1 41  ? -15.354 28.128  -15.687 1.00 7.57  ? 66  PHE B CD2 1 
ATOM   2390 C CE1 . PHE B 1 41  ? -13.353 30.001  -15.222 1.00 10.38 ? 66  PHE B CE1 1 
ATOM   2391 C CE2 . PHE B 1 41  ? -14.522 28.543  -16.724 1.00 9.09  ? 66  PHE B CE2 1 
ATOM   2392 C CZ  . PHE B 1 41  ? -13.524 29.478  -16.486 1.00 10.84 ? 66  PHE B CZ  1 
ATOM   2393 N N   . PRO B 1 42  ? -19.181 27.790  -12.373 1.00 8.61  ? 67  PRO B N   1 
ATOM   2394 C CA  . PRO B 1 42  ? -19.997 26.986  -11.449 1.00 9.12  ? 67  PRO B CA  1 
ATOM   2395 C C   . PRO B 1 42  ? -19.196 25.803  -10.925 1.00 9.75  ? 67  PRO B C   1 
ATOM   2396 O O   . PRO B 1 42  ? -18.565 25.073  -11.693 1.00 12.69 ? 67  PRO B O   1 
ATOM   2397 C CB  . PRO B 1 42  ? -21.187 26.524  -12.302 1.00 12.16 ? 67  PRO B CB  1 
ATOM   2398 C CG  . PRO B 1 42  ? -20.932 26.991  -13.696 1.00 13.33 ? 67  PRO B CG  1 
ATOM   2399 C CD  . PRO B 1 42  ? -19.569 27.608  -13.784 1.00 12.97 ? 67  PRO B CD  1 
ATOM   2400 N N   . MET B 1 43  ? -19.229 25.617  -9.603  1.00 9.80  ? 68  MET B N   1 
ATOM   2401 C CA  . MET B 1 43  ? -18.418 24.596  -8.938  1.00 11.40 ? 68  MET B CA  1 
ATOM   2402 C C   . MET B 1 43  ? -18.979 23.195  -9.104  1.00 8.93  ? 68  MET B C   1 
ATOM   2403 O O   . MET B 1 43  ? -18.207 22.227  -9.197  1.00 8.48  ? 68  MET B O   1 
ATOM   2404 C CB  . MET B 1 43  ? -18.355 24.937  -7.457  1.00 11.61 ? 68  MET B CB  1 
ATOM   2405 C CG  . MET B 1 43  ? -17.594 26.208  -7.180  1.00 10.50 ? 68  MET B CG  1 
ATOM   2406 S SD  . MET B 1 43  ? -17.274 26.386  -5.420  1.00 11.00 ? 68  MET B SD  1 
ATOM   2407 C CE  . MET B 1 43  ? -18.876 27.050  -4.928  1.00 11.21 ? 68  MET B CE  1 
ATOM   2408 N N   . CYS B 1 44  ? -20.314 23.073  -9.131  1.00 9.46  ? 69  CYS B N   1 
ATOM   2409 C CA  . CYS B 1 44  ? -20.990 21.781  -9.057  1.00 8.70  ? 69  CYS B CA  1 
ATOM   2410 C C   . CYS B 1 44  ? -20.380 20.960  -7.925  1.00 10.50 ? 69  CYS B C   1 
ATOM   2411 O O   . CYS B 1 44  ? -20.151 21.513  -6.846  1.00 11.09 ? 69  CYS B O   1 
ATOM   2412 C CB  . CYS B 1 44  ? -20.959 21.069  -10.421 1.00 9.73  ? 69  CYS B CB  1 
ATOM   2413 S SG  . CYS B 1 44  ? -21.725 22.126  -11.726 1.00 13.10 ? 69  CYS B SG  1 
ATOM   2414 N N   . SER B 1 45  ? -20.100 19.675  -8.138  1.00 9.77  ? 70  SER B N   1 
ATOM   2415 C CA  . SER B 1 45  ? -19.734 18.841  -6.993  1.00 9.21  ? 70  SER B CA  1 
ATOM   2416 C C   . SER B 1 45  ? -18.337 19.118  -6.455  1.00 8.26  ? 70  SER B C   1 
ATOM   2417 O O   . SER B 1 45  ? -17.993 18.574  -5.406  1.00 7.86  ? 70  SER B O   1 
ATOM   2418 C CB  . SER B 1 45  ? -19.857 17.356  -7.337  1.00 8.77  ? 70  SER B CB  1 
ATOM   2419 O OG  . SER B 1 45  ? -21.210 16.945  -7.254  1.00 12.46 ? 70  SER B OG  1 
ATOM   2420 N N   . THR B 1 46  ? -17.518 19.946  -7.114  1.00 6.89  ? 71  THR B N   1 
ATOM   2421 C CA  . THR B 1 46  ? -16.245 20.292  -6.474  1.00 8.57  ? 71  THR B CA  1 
ATOM   2422 C C   . THR B 1 46  ? -16.453 21.072  -5.174  1.00 7.82  ? 71  THR B C   1 
ATOM   2423 O O   . THR B 1 46  ? -15.556 21.091  -4.322  1.00 8.89  ? 71  THR B O   1 
ATOM   2424 C CB  . THR B 1 46  ? -15.324 21.081  -7.423  1.00 7.96  ? 71  THR B CB  1 
ATOM   2425 O OG1 . THR B 1 46  ? -15.858 22.387  -7.694  1.00 8.91  ? 71  THR B OG1 1 
ATOM   2426 C CG2 . THR B 1 46  ? -15.079 20.315  -8.733  1.00 9.11  ? 71  THR B CG2 1 
ATOM   2427 N N   . SER B 1 47  ? -17.630 21.677  -4.974  1.00 8.58  ? 72  SER B N   1 
ATOM   2428 C CA  . SER B 1 47  ? -17.942 22.317  -3.704  1.00 9.74  ? 72  SER B CA  1 
ATOM   2429 C C   . SER B 1 47  ? -18.027 21.330  -2.548  1.00 10.13 ? 72  SER B C   1 
ATOM   2430 O O   . SER B 1 47  ? -17.990 21.751  -1.385  1.00 9.74  ? 72  SER B O   1 
ATOM   2431 C CB  . SER B 1 47  ? -19.266 23.081  -3.814  1.00 9.75  ? 72  SER B CB  1 
ATOM   2432 O OG  . SER B 1 47  ? -20.340 22.222  -4.142  1.00 11.17 ? 72  SER B OG  1 
ATOM   2433 N N   . LYS B 1 48  ? -18.115 20.031  -2.826  1.00 8.69  ? 73  LYS B N   1 
ATOM   2434 C CA  . LYS B 1 48  ? -18.188 19.053  -1.747  1.00 7.22  ? 73  LYS B CA  1 
ATOM   2435 C C   . LYS B 1 48  ? -16.908 19.041  -0.931  1.00 8.20  ? 73  LYS B C   1 
ATOM   2436 O O   . LYS B 1 48  ? -16.937 18.703  0.250   1.00 8.09  ? 73  LYS B O   1 
ATOM   2437 C CB  . LYS B 1 48  ? -18.478 17.663  -2.317  1.00 8.21  ? 73  LYS B CB  1 
ATOM   2438 C CG  . LYS B 1 48  ? -19.893 17.515  -2.838  1.00 8.15  ? 73  LYS B CG  1 
ATOM   2439 C CD  . LYS B 1 48  ? -20.028 16.177  -3.563  1.00 10.48 ? 73  LYS B CD  1 
ATOM   2440 C CE  . LYS B 1 48  ? -21.467 15.807  -3.859  1.00 13.97 ? 73  LYS B CE  1 
ATOM   2441 N NZ  . LYS B 1 48  ? -22.164 16.857  -4.600  1.00 16.28 ? 73  LYS B NZ  1 
ATOM   2442 N N   . VAL B 1 49  ? -15.780 19.432  -1.533  1.00 6.64  ? 74  VAL B N   1 
ATOM   2443 C CA  . VAL B 1 49  ? -14.536 19.503  -0.775  1.00 6.51  ? 74  VAL B CA  1 
ATOM   2444 C C   . VAL B 1 49  ? -14.639 20.550  0.324   1.00 8.42  ? 74  VAL B C   1 
ATOM   2445 O O   . VAL B 1 49  ? -14.227 20.312  1.465   1.00 8.41  ? 74  VAL B O   1 
ATOM   2446 C CB  . VAL B 1 49  ? -13.339 19.781  -1.703  1.00 6.25  ? 74  VAL B CB  1 
ATOM   2447 C CG1 . VAL B 1 49  ? -12.078 19.941  -0.870  1.00 10.62 ? 74  VAL B CG1 1 
ATOM   2448 C CG2 . VAL B 1 49  ? -13.156 18.644  -2.701  1.00 7.78  ? 74  VAL B CG2 1 
ATOM   2449 N N   . MET B 1 50  ? -15.204 21.717  0.013   1.00 7.81  ? 75  MET B N   1 
ATOM   2450 C CA  . MET B 1 50  ? -15.291 22.748  1.041   1.00 8.10  ? 75  MET B CA  1 
ATOM   2451 C C   . MET B 1 50  ? -16.232 22.327  2.159   1.00 9.07  ? 75  MET B C   1 
ATOM   2452 O O   . MET B 1 50  ? -15.950 22.582  3.336   1.00 9.44  ? 75  MET B O   1 
ATOM   2453 C CB  . MET B 1 50  ? -15.704 24.086  0.414   1.00 8.45  ? 75  MET B CB  1 
ATOM   2454 C CG  . MET B 1 50  ? -15.608 25.229  1.404   1.00 8.99  ? 75  MET B CG  1 
ATOM   2455 S SD  . MET B 1 50  ? -13.915 25.893  1.498   1.00 12.19 ? 75  MET B SD  1 
ATOM   2456 C CE  . MET B 1 50  ? -13.733 26.677  -0.104  1.00 12.79 ? 75  MET B CE  1 
ATOM   2457 N N   . ALA B 1 51  ? -17.338 21.666  1.820   1.00 7.81  ? 76  ALA B N   1 
ATOM   2458 C CA  . ALA B 1 51  ? -18.276 21.224  2.844   1.00 6.85  ? 76  ALA B CA  1 
ATOM   2459 C C   . ALA B 1 51  ? -17.669 20.140  3.729   1.00 9.24  ? 76  ALA B C   1 
ATOM   2460 O O   . ALA B 1 51  ? -17.804 20.183  4.958   1.00 9.33  ? 76  ALA B O   1 
ATOM   2461 C CB  . ALA B 1 51  ? -19.561 20.726  2.187   1.00 10.17 ? 76  ALA B CB  1 
ATOM   2462 N N   . ALA B 1 52  ? -17.015 19.143  3.130   1.00 8.92  ? 77  ALA B N   1 
ATOM   2463 C CA  . ALA B 1 52  ? -16.373 18.117  3.944   1.00 9.10  ? 77  ALA B CA  1 
ATOM   2464 C C   . ALA B 1 52  ? -15.291 18.721  4.826   1.00 9.46  ? 77  ALA B C   1 
ATOM   2465 O O   . ALA B 1 52  ? -15.180 18.364  6.004   1.00 9.24  ? 77  ALA B O   1 
ATOM   2466 C CB  . ALA B 1 52  ? -15.789 17.016  3.053   1.00 9.11  ? 77  ALA B CB  1 
ATOM   2467 N N   . ALA B 1 53  ? -14.500 19.660  4.285   1.00 9.63  ? 78  ALA B N   1 
ATOM   2468 C CA  . ALA B 1 53  ? -13.451 20.286  5.085   1.00 8.25  ? 78  ALA B CA  1 
ATOM   2469 C C   . ALA B 1 53  ? -14.034 21.102  6.235   1.00 9.19  ? 78  ALA B C   1 
ATOM   2470 O O   . ALA B 1 53  ? -13.467 21.126  7.335   1.00 9.24  ? 78  ALA B O   1 
ATOM   2471 C CB  . ALA B 1 53  ? -12.566 21.155  4.193   1.00 7.90  ? 78  ALA B CB  1 
ATOM   2472 N N   . ALA B 1 54  ? -15.187 21.741  6.018   1.00 8.34  ? 79  ALA B N   1 
ATOM   2473 C CA  . ALA B 1 54  ? -15.799 22.522  7.089   1.00 7.63  ? 79  ALA B CA  1 
ATOM   2474 C C   . ALA B 1 54  ? -16.232 21.624  8.239   1.00 9.28  ? 79  ALA B C   1 
ATOM   2475 O O   . ALA B 1 54  ? -16.091 21.993  9.416   1.00 9.35  ? 79  ALA B O   1 
ATOM   2476 C CB  . ALA B 1 54  ? -16.995 23.299  6.547   1.00 8.03  ? 79  ALA B CB  1 
ATOM   2477 N N   . VAL B 1 55  ? -16.763 20.440  7.921   1.00 7.63  ? 80  VAL B N   1 
ATOM   2478 C CA  . VAL B 1 55  ? -17.150 19.486  8.960   1.00 8.71  ? 80  VAL B CA  1 
ATOM   2479 C C   . VAL B 1 55  ? -15.911 18.922  9.650   1.00 9.59  ? 80  VAL B C   1 
ATOM   2480 O O   . VAL B 1 55  ? -15.900 18.734  10.873  1.00 9.72  ? 80  VAL B O   1 
ATOM   2481 C CB  . VAL B 1 55  ? -18.030 18.379  8.350   1.00 8.59  ? 80  VAL B CB  1 
ATOM   2482 C CG1 . VAL B 1 55  ? -18.273 17.257  9.362   1.00 9.52  ? 80  VAL B CG1 1 
ATOM   2483 C CG2 . VAL B 1 55  ? -19.359 18.952  7.855   1.00 10.70 ? 80  VAL B CG2 1 
ATOM   2484 N N   . LEU B 1 56  ? -14.849 18.643  8.889   1.00 7.34  ? 81  LEU B N   1 
ATOM   2485 C CA  . LEU B 1 56  ? -13.584 18.270  9.521   1.00 5.61  ? 81  LEU B CA  1 
ATOM   2486 C C   . LEU B 1 56  ? -13.122 19.340  10.506  1.00 7.79  ? 81  LEU B C   1 
ATOM   2487 O O   . LEU B 1 56  ? -12.639 19.018  11.599  1.00 11.69 ? 81  LEU B O   1 
ATOM   2488 C CB  . LEU B 1 56  ? -12.525 18.008  8.447   1.00 9.16  ? 81  LEU B CB  1 
ATOM   2489 C CG  . LEU B 1 56  ? -12.634 16.656  7.732   1.00 6.98  ? 81  LEU B CG  1 
ATOM   2490 C CD1 . LEU B 1 56  ? -11.680 16.638  6.542   1.00 8.90  ? 81  LEU B CD1 1 
ATOM   2491 C CD2 . LEU B 1 56  ? -12.359 15.468  8.664   1.00 11.56 ? 81  LEU B CD2 1 
ATOM   2492 N N   . LYS B 1 57  ? -13.252 20.620  10.145  1.00 8.42  ? 82  LYS B N   1 
ATOM   2493 C CA  . LYS B 1 57  ? -12.858 21.669  11.078  1.00 8.21  ? 82  LYS B CA  1 
ATOM   2494 C C   . LYS B 1 57  ? -13.716 21.626  12.342  1.00 9.86  ? 82  LYS B C   1 
ATOM   2495 O O   . LYS B 1 57  ? -13.196 21.752  13.454  1.00 11.05 ? 82  LYS B O   1 
ATOM   2496 C CB  . LYS B 1 57  ? -12.935 23.032  10.393  1.00 8.58  ? 82  LYS B CB  1 
ATOM   2497 C CG  . LYS B 1 57  ? -12.709 24.241  11.333  1.00 9.61  ? 82  LYS B CG  1 
ATOM   2498 C CD  . LYS B 1 57  ? -11.359 24.205  12.041  1.00 11.92 ? 82  LYS B CD  1 
ATOM   2499 C CE  . LYS B 1 57  ? -10.224 24.338  11.048  1.00 12.35 ? 82  LYS B CE  1 
ATOM   2500 N NZ  . LYS B 1 57  ? -8.883  24.427  11.730  1.00 13.09 ? 82  LYS B NZ  1 
ATOM   2501 N N   . GLN B 1 58  ? -15.021 21.399  12.192  1.00 9.38  ? 83  GLN B N   1 
ATOM   2502 C CA  . GLN B 1 58  ? -15.875 21.259  13.371  1.00 7.42  ? 83  GLN B CA  1 
ATOM   2503 C C   . GLN B 1 58  ? -15.408 20.115  14.251  1.00 9.53  ? 83  GLN B C   1 
ATOM   2504 O O   . GLN B 1 58  ? -15.435 20.220  15.485  1.00 9.55  ? 83  GLN B O   1 
ATOM   2505 C CB  . GLN B 1 58  ? -17.315 21.028  12.944  1.00 7.76  ? 83  GLN B CB  1 
ATOM   2506 C CG  . GLN B 1 58  ? -18.047 22.209  12.379  1.00 8.67  ? 83  GLN B CG  1 
ATOM   2507 C CD  . GLN B 1 58  ? -19.464 21.809  12.011  1.00 13.21 ? 83  GLN B CD  1 
ATOM   2508 O OE1 . GLN B 1 58  ? -19.703 20.677  11.564  1.00 13.39 ? 83  GLN B OE1 1 
ATOM   2509 N NE2 . GLN B 1 58  ? -20.400 22.711  12.203  1.00 14.95 ? 83  GLN B NE2 1 
ATOM   2510 N N   . SER B 1 59  ? -14.964 19.013  13.639  1.00 9.59  ? 84  SER B N   1 
ATOM   2511 C CA  . SER B 1 59  ? -14.559 17.843  14.411  1.00 9.41  ? 84  SER B CA  1 
ATOM   2512 C C   . SER B 1 59  ? -13.291 18.079  15.218  1.00 13.67 ? 84  SER B C   1 
ATOM   2513 O O   . SER B 1 59  ? -12.991 17.283  16.114  1.00 12.75 ? 84  SER B O   1 
ATOM   2514 C CB  . SER B 1 59  ? -14.385 16.640  13.481  1.00 11.20 ? 84  SER B CB  1 
ATOM   2515 O OG  . SER B 1 59  ? -13.149 16.711  12.797  1.00 11.49 ? 84  SER B OG  1 
ATOM   2516 N N   . GLU B 1 60  ? -12.549 19.155  14.945  1.00 9.33  ? 85  GLU B N   1 
ATOM   2517 C CA  . GLU B 1 60  ? -11.352 19.428  15.733  1.00 10.05 ? 85  GLU B CA  1 
ATOM   2518 C C   . GLU B 1 60  ? -11.698 19.775  17.165  1.00 12.82 ? 85  GLU B C   1 
ATOM   2519 O O   . GLU B 1 60  ? -10.870 19.571  18.062  1.00 16.11 ? 85  GLU B O   1 
ATOM   2520 C CB  . GLU B 1 60  ? -10.535 20.554  15.110  1.00 11.42 ? 85  GLU B CB  1 
ATOM   2521 C CG  . GLU B 1 60  ? -10.026 20.194  13.745  1.00 11.92 ? 85  GLU B CG  1 
ATOM   2522 C CD  . GLU B 1 60  ? -9.263  21.313  13.066  1.00 13.47 ? 85  GLU B CD  1 
ATOM   2523 O OE1 . GLU B 1 60  ? -8.801  22.266  13.739  1.00 16.13 ? 85  GLU B OE1 1 
ATOM   2524 O OE2 . GLU B 1 60  ? -9.135  21.229  11.833  1.00 13.18 ? 85  GLU B OE2 1 
ATOM   2525 N N   . THR B 1 61  ? -12.900 20.281  17.414  1.00 10.54 ? 86  THR B N   1 
ATOM   2526 C CA  . THR B 1 61  ? -13.298 20.563  18.786  1.00 10.41 ? 86  THR B CA  1 
ATOM   2527 C C   . THR B 1 61  ? -14.380 19.603  19.279  1.00 15.53 ? 86  THR B C   1 
ATOM   2528 O O   . THR B 1 61  ? -14.950 19.825  20.356  1.00 14.28 ? 86  THR B O   1 
ATOM   2529 C CB  . THR B 1 61  ? -13.747 22.023  18.924  1.00 12.10 ? 86  THR B CB  1 
ATOM   2530 O OG1 . THR B 1 61  ? -14.719 22.353  17.923  1.00 13.69 ? 86  THR B OG1 1 
ATOM   2531 C CG2 . THR B 1 61  ? -12.551 22.970  18.803  1.00 13.22 ? 86  THR B CG2 1 
ATOM   2532 N N   . GLN B 1 62  ? -14.647 18.529  18.531  1.00 13.98 ? 87  GLN B N   1 
ATOM   2533 C CA  . GLN B 1 62  ? -15.616 17.485  18.892  1.00 18.38 ? 87  GLN B CA  1 
ATOM   2534 C C   . GLN B 1 62  ? -15.062 16.151  18.405  1.00 17.51 ? 87  GLN B C   1 
ATOM   2535 O O   . GLN B 1 62  ? -15.273 15.775  17.244  1.00 18.68 ? 87  GLN B O   1 
ATOM   2536 C CB  . GLN B 1 62  ? -16.982 17.729  18.279  1.00 12.78 ? 87  GLN B CB  1 
ATOM   2537 C CG  . GLN B 1 62  ? -17.668 18.995  18.680  1.00 14.35 ? 87  GLN B CG  1 
ATOM   2538 C CD  . GLN B 1 62  ? -19.053 19.043  18.096  1.00 17.43 ? 87  GLN B CD  1 
ATOM   2539 O OE1 . GLN B 1 62  ? -19.904 18.231  18.444  1.00 17.15 ? 87  GLN B OE1 1 
ATOM   2540 N NE2 . GLN B 1 62  ? -19.281 19.974  17.182  1.00 15.82 ? 87  GLN B NE2 1 
ATOM   2541 N N   . LYS B 1 63  ? -14.396 15.427  19.301  1.00 20.24 ? 88  LYS B N   1 
ATOM   2542 C CA  . LYS B 1 63  ? -13.655 14.237  18.892  1.00 23.28 ? 88  LYS B CA  1 
ATOM   2543 C C   . LYS B 1 63  ? -14.571 13.165  18.309  1.00 23.25 ? 88  LYS B C   1 
ATOM   2544 O O   . LYS B 1 63  ? -14.140 12.378  17.456  1.00 35.14 ? 88  LYS B O   1 
ATOM   2545 C CB  . LYS B 1 63  ? -12.862 13.694  20.085  1.00 21.93 ? 88  LYS B CB  1 
ATOM   2546 C CG  . LYS B 1 63  ? -12.302 12.291  19.905  1.00 43.88 ? 88  LYS B CG  1 
ATOM   2547 C CD  . LYS B 1 63  ? -11.491 11.863  21.122  1.00 49.77 ? 88  LYS B CD  1 
ATOM   2548 C CE  . LYS B 1 63  ? -10.527 10.739  20.774  1.00 54.87 ? 88  LYS B CE  1 
ATOM   2549 N NZ  . LYS B 1 63  ? -9.678  11.104  19.602  1.00 53.82 ? 88  LYS B NZ  1 
ATOM   2550 N N   . GLN B 1 64  ? -15.833 13.125  18.726  1.00 17.66 ? 89  GLN B N   1 
ATOM   2551 C CA  . GLN B 1 64  ? -16.762 12.103  18.260  1.00 17.54 ? 89  GLN B CA  1 
ATOM   2552 C C   . GLN B 1 64  ? -17.688 12.588  17.153  1.00 18.09 ? 89  GLN B C   1 
ATOM   2553 O O   . GLN B 1 64  ? -18.623 11.866  16.793  1.00 17.84 ? 89  GLN B O   1 
ATOM   2554 C CB  . GLN B 1 64  ? -17.599 11.579  19.434  1.00 26.81 ? 89  GLN B CB  1 
ATOM   2555 C CG  . GLN B 1 64  ? -16.868 10.585  20.340  1.00 41.75 ? 89  GLN B CG  1 
ATOM   2556 C CD  . GLN B 1 64  ? -16.035 9.560   19.583  1.00 43.16 ? 89  GLN B CD  1 
ATOM   2557 O OE1 . GLN B 1 64  ? -14.806 9.625   19.586  1.00 37.07 ? 89  GLN B OE1 1 
ATOM   2558 N NE2 . GLN B 1 64  ? -16.700 8.572   18.984  1.00 34.44 ? 89  GLN B NE2 1 
ATOM   2559 N N   . LEU B 1 65  ? -17.448 13.779  16.591  1.00 15.39 ? 90  LEU B N   1 
ATOM   2560 C CA  . LEU B 1 65  ? -18.406 14.342  15.639  1.00 16.11 ? 90  LEU B CA  1 
ATOM   2561 C C   . LEU B 1 65  ? -18.567 13.450  14.418  1.00 11.74 ? 90  LEU B C   1 
ATOM   2562 O O   . LEU B 1 65  ? -19.687 13.241  13.931  1.00 13.08 ? 90  LEU B O   1 
ATOM   2563 C CB  . LEU B 1 65  ? -17.981 15.750  15.210  1.00 14.89 ? 90  LEU B CB  1 
ATOM   2564 C CG  . LEU B 1 65  ? -18.927 16.418  14.205  1.00 10.56 ? 90  LEU B CG  1 
ATOM   2565 C CD1 . LEU B 1 65  ? -20.307 16.632  14.828  1.00 11.84 ? 90  LEU B CD1 1 
ATOM   2566 C CD2 . LEU B 1 65  ? -18.358 17.730  13.716  1.00 12.24 ? 90  LEU B CD2 1 
ATOM   2567 N N   . LEU B 1 66  ? -17.462 12.937  13.889  1.00 14.55 ? 91  LEU B N   1 
ATOM   2568 C CA  . LEU B 1 66  ? -17.549 12.153  12.666  1.00 11.24 ? 91  LEU B CA  1 
ATOM   2569 C C   . LEU B 1 66  ? -18.275 10.831  12.875  1.00 12.13 ? 91  LEU B C   1 
ATOM   2570 O O   . LEU B 1 66  ? -18.648 10.190  11.891  1.00 11.33 ? 91  LEU B O   1 
ATOM   2571 C CB  . LEU B 1 66  ? -16.148 11.908  12.101  1.00 12.36 ? 91  LEU B CB  1 
ATOM   2572 C CG  . LEU B 1 66  ? -15.415 13.174  11.632  1.00 13.07 ? 91  LEU B CG  1 
ATOM   2573 C CD1 . LEU B 1 66  ? -14.058 12.813  11.074  1.00 17.47 ? 91  LEU B CD1 1 
ATOM   2574 C CD2 . LEU B 1 66  ? -16.220 13.913  10.581  1.00 20.17 ? 91  LEU B CD2 1 
ATOM   2575 N N   . ASN B 1 67  ? -18.507 10.415  14.118  1.00 11.79 ? 92  ASN B N   1 
ATOM   2576 C CA  . ASN B 1 67  ? -19.294 9.221   14.384  1.00 10.41 ? 92  ASN B CA  1 
ATOM   2577 C C   . ASN B 1 67  ? -20.748 9.541   14.695  1.00 11.94 ? 92  ASN B C   1 
ATOM   2578 O O   . ASN B 1 67  ? -21.526 8.623   14.967  1.00 15.65 ? 92  ASN B O   1 
ATOM   2579 C CB  . ASN B 1 67  ? -18.685 8.420   15.541  1.00 12.40 ? 92  ASN B CB  1 
ATOM   2580 C CG  . ASN B 1 67  ? -17.315 7.884   15.209  1.00 14.35 ? 92  ASN B CG  1 
ATOM   2581 O OD1 . ASN B 1 67  ? -17.007 7.611   14.049  1.00 16.58 ? 92  ASN B OD1 1 
ATOM   2582 N ND2 . ASN B 1 67  ? -16.480 7.727   16.223  1.00 20.24 ? 92  ASN B ND2 1 
ATOM   2583 N N   . GLN B 1 68  ? -21.127 10.811  14.634  1.00 12.30 ? 93  GLN B N   1 
ATOM   2584 C CA  . GLN B 1 68  ? -22.491 11.216  14.930  1.00 15.15 ? 93  GLN B CA  1 
ATOM   2585 C C   . GLN B 1 68  ? -23.443 10.739  13.839  1.00 12.77 ? 93  GLN B C   1 
ATOM   2586 O O   . GLN B 1 68  ? -23.218 11.024  12.655  1.00 13.69 ? 93  GLN B O   1 
ATOM   2587 C CB  . GLN B 1 68  ? -22.539 12.736  15.056  1.00 18.91 ? 93  GLN B CB  1 
ATOM   2588 C CG  . GLN B 1 68  ? -23.847 13.304  15.555  1.00 20.96 ? 93  GLN B CG  1 
ATOM   2589 C CD  . GLN B 1 68  ? -23.750 14.804  15.805  1.00 18.58 ? 93  GLN B CD  1 
ATOM   2590 O OE1 . GLN B 1 68  ? -24.424 15.601  15.146  1.00 23.24 ? 93  GLN B OE1 1 
ATOM   2591 N NE2 . GLN B 1 68  ? -22.897 15.189  16.752  1.00 17.40 ? 93  GLN B NE2 1 
ATOM   2592 N N   . PRO B 1 69  ? -24.523 10.056  14.188  1.00 12.97 ? 94  PRO B N   1 
ATOM   2593 C CA  . PRO B 1 69  ? -25.468 9.585   13.176  1.00 16.41 ? 94  PRO B CA  1 
ATOM   2594 C C   . PRO B 1 69  ? -26.383 10.691  12.684  1.00 16.89 ? 94  PRO B C   1 
ATOM   2595 O O   . PRO B 1 69  ? -26.762 11.604  13.422  1.00 16.84 ? 94  PRO B O   1 
ATOM   2596 C CB  . PRO B 1 69  ? -26.267 8.514   13.926  1.00 17.47 ? 94  PRO B CB  1 
ATOM   2597 C CG  . PRO B 1 69  ? -26.299 9.053   15.325  1.00 23.00 ? 94  PRO B CG  1 
ATOM   2598 C CD  . PRO B 1 69  ? -24.920 9.643   15.541  1.00 12.27 ? 94  PRO B CD  1 
ATOM   2599 N N   . VAL B 1 70  ? -26.750 10.579  11.410  1.00 14.22 ? 95  VAL B N   1 
ATOM   2600 C CA  . VAL B 1 70  ? -27.663 11.495  10.737  1.00 15.49 ? 95  VAL B CA  1 
ATOM   2601 C C   . VAL B 1 70  ? -28.743 10.653  10.077  1.00 13.61 ? 95  VAL B C   1 
ATOM   2602 O O   . VAL B 1 70  ? -28.425 9.717   9.336   1.00 12.73 ? 95  VAL B O   1 
ATOM   2603 C CB  . VAL B 1 70  ? -26.924 12.342  9.682   1.00 12.12 ? 95  VAL B CB  1 
ATOM   2604 C CG1 . VAL B 1 70  ? -27.885 13.240  8.957   1.00 14.36 ? 95  VAL B CG1 1 
ATOM   2605 C CG2 . VAL B 1 70  ? -25.795 13.129  10.325  1.00 16.70 ? 95  VAL B CG2 1 
ATOM   2606 N N   . GLU B 1 71  ? -30.010 10.960  10.349  1.00 15.21 ? 96  GLU B N   1 
ATOM   2607 C CA  . GLU B 1 71  ? -31.075 10.178  9.732   1.00 13.06 ? 96  GLU B CA  1 
ATOM   2608 C C   . GLU B 1 71  ? -31.216 10.502  8.253   1.00 14.36 ? 96  GLU B C   1 
ATOM   2609 O O   . GLU B 1 71  ? -31.154 11.665  7.837   1.00 13.67 ? 96  GLU B O   1 
ATOM   2610 C CB  . GLU B 1 71  ? -32.420 10.390  10.430  1.00 16.63 ? 96  GLU B CB  1 
ATOM   2611 C CG  . GLU B 1 71  ? -32.401 10.384  11.934  1.00 22.37 ? 96  GLU B CG  1 
ATOM   2612 C CD  . GLU B 1 71  ? -33.796 10.550  12.511  1.00 39.12 ? 96  GLU B CD  1 
ATOM   2613 O OE1 . GLU B 1 71  ? -34.148 9.790   13.438  1.00 38.83 ? 96  GLU B OE1 1 
ATOM   2614 O OE2 . GLU B 1 71  ? -34.553 11.410  12.013  1.00 42.57 ? 96  GLU B OE2 1 
ATOM   2615 N N   . ILE B 1 72  ? -31.403 9.450   7.459   1.00 13.58 ? 97  ILE B N   1 
ATOM   2616 C CA  . ILE B 1 72  ? -31.695 9.540   6.033   1.00 14.99 ? 97  ILE B CA  1 
ATOM   2617 C C   . ILE B 1 72  ? -33.144 9.121   5.828   1.00 11.49 ? 97  ILE B C   1 
ATOM   2618 O O   . ILE B 1 72  ? -33.513 7.984   6.140   1.00 16.42 ? 97  ILE B O   1 
ATOM   2619 C CB  . ILE B 1 72  ? -30.765 8.646   5.197   1.00 12.15 ? 97  ILE B CB  1 
ATOM   2620 C CG1 . ILE B 1 72  ? -29.299 8.814   5.614   1.00 14.72 ? 97  ILE B CG1 1 
ATOM   2621 C CG2 . ILE B 1 72  ? -30.990 8.910   3.717   1.00 13.76 ? 97  ILE B CG2 1 
ATOM   2622 C CD1 . ILE B 1 72  ? -28.791 10.211  5.467   1.00 13.11 ? 97  ILE B CD1 1 
ATOM   2623 N N   . LYS B 1 73  ? -33.953 10.017  5.302   1.00 15.13 ? 98  LYS B N   1 
ATOM   2624 C CA  . LYS B 1 73  ? -35.359 9.745   5.067   1.00 16.26 ? 98  LYS B CA  1 
ATOM   2625 C C   . LYS B 1 73  ? -35.660 9.732   3.573   1.00 17.70 ? 98  LYS B C   1 
ATOM   2626 O O   . LYS B 1 73  ? -34.936 10.341  2.779   1.00 15.62 ? 98  LYS B O   1 
ATOM   2627 C CB  . LYS B 1 73  ? -36.221 10.806  5.764   1.00 20.62 ? 98  LYS B CB  1 
ATOM   2628 C CG  . LYS B 1 73  ? -36.207 10.709  7.279   1.00 23.82 ? 98  LYS B CG  1 
ATOM   2629 C CD  . LYS B 1 73  ? -37.019 9.519   7.771   1.00 39.94 ? 98  LYS B CD  1 
ATOM   2630 C CE  . LYS B 1 73  ? -37.023 9.432   9.294   1.00 45.92 ? 98  LYS B CE  1 
ATOM   2631 N NZ  . LYS B 1 73  ? -36.389 8.172   9.790   1.00 35.08 ? 98  LYS B NZ  1 
ATOM   2632 N N   . PRO B 1 74  ? -36.722 9.037   3.146   1.00 23.16 ? 99  PRO B N   1 
ATOM   2633 C CA  . PRO B 1 74  ? -37.058 9.031   1.711   1.00 23.45 ? 99  PRO B CA  1 
ATOM   2634 C C   . PRO B 1 74  ? -37.116 10.414  1.088   1.00 19.61 ? 99  PRO B C   1 
ATOM   2635 O O   . PRO B 1 74  ? -36.663 10.588  -0.050  1.00 22.01 ? 99  PRO B O   1 
ATOM   2636 C CB  . PRO B 1 74  ? -38.425 8.338   1.689   1.00 24.12 ? 99  PRO B CB  1 
ATOM   2637 C CG  . PRO B 1 74  ? -38.381 7.431   2.845   1.00 21.62 ? 99  PRO B CG  1 
ATOM   2638 C CD  . PRO B 1 74  ? -37.640 8.185   3.923   1.00 20.62 ? 99  PRO B CD  1 
ATOM   2639 N N   . ALA B 1 75  ? -37.639 11.411  1.810   1.00 18.50 ? 100 ALA B N   1 
ATOM   2640 C CA  . ALA B 1 75  ? -37.703 12.769  1.281   1.00 21.02 ? 100 ALA B CA  1 
ATOM   2641 C C   . ALA B 1 75  ? -36.326 13.390  1.066   1.00 21.59 ? 100 ALA B C   1 
ATOM   2642 O O   . ALA B 1 75  ? -36.213 14.363  0.314   1.00 25.08 ? 100 ALA B O   1 
ATOM   2643 C CB  . ALA B 1 75  ? -38.527 13.659  2.212   1.00 28.25 ? 100 ALA B CB  1 
ATOM   2644 N N   . ASP B 1 76  ? -35.283 12.859  1.707   1.00 18.23 ? 101 ASP B N   1 
ATOM   2645 C CA  . ASP B 1 76  ? -33.948 13.437  1.575   1.00 14.90 ? 101 ASP B CA  1 
ATOM   2646 C C   . ASP B 1 76  ? -33.252 13.057  0.282   1.00 18.08 ? 101 ASP B C   1 
ATOM   2647 O O   . ASP B 1 76  ? -32.239 13.682  -0.059  1.00 17.14 ? 101 ASP B O   1 
ATOM   2648 C CB  . ASP B 1 76  ? -33.047 13.001  2.729   1.00 17.93 ? 101 ASP B CB  1 
ATOM   2649 C CG  . ASP B 1 76  ? -33.565 13.442  4.068   1.00 23.66 ? 101 ASP B CG  1 
ATOM   2650 O OD1 . ASP B 1 76  ? -34.296 14.451  4.120   1.00 31.55 ? 101 ASP B OD1 1 
ATOM   2651 O OD2 . ASP B 1 76  ? -33.240 12.776  5.069   1.00 19.70 ? 101 ASP B OD2 1 
ATOM   2652 N N   . LEU B 1 77  ? -33.728 12.028  -0.414  1.00 17.51 ? 102 LEU B N   1 
ATOM   2653 C CA  . LEU B 1 77  ? -33.062 11.601  -1.635  1.00 12.66 ? 102 LEU B CA  1 
ATOM   2654 C C   . LEU B 1 77  ? -33.273 12.627  -2.736  1.00 16.43 ? 102 LEU B C   1 
ATOM   2655 O O   . LEU B 1 77  ? -34.380 13.136  -2.932  1.00 21.99 ? 102 LEU B O   1 
ATOM   2656 C CB  . LEU B 1 77  ? -33.569 10.233  -2.085  1.00 14.88 ? 102 LEU B CB  1 
ATOM   2657 C CG  . LEU B 1 77  ? -33.380 9.103   -1.090  1.00 16.42 ? 102 LEU B CG  1 
ATOM   2658 C CD1 . LEU B 1 77  ? -33.949 7.808   -1.669  1.00 20.08 ? 102 LEU B CD1 1 
ATOM   2659 C CD2 . LEU B 1 77  ? -31.891 8.956   -0.754  1.00 15.44 ? 102 LEU B CD2 1 
ATOM   2660 N N   . VAL B 1 78  ? -32.194 12.948  -3.445  1.00 13.50 ? 103 VAL B N   1 
ATOM   2661 C CA  . VAL B 1 78  ? -32.295 13.886  -4.556  1.00 15.33 ? 103 VAL B CA  1 
ATOM   2662 C C   . VAL B 1 78  ? -32.015 13.126  -5.853  1.00 19.71 ? 103 VAL B C   1 
ATOM   2663 O O   . VAL B 1 78  ? -32.579 12.048  -6.071  1.00 23.48 ? 103 VAL B O   1 
ATOM   2664 C CB  . VAL B 1 78  ? -31.382 15.109  -4.330  1.00 15.89 ? 103 VAL B CB  1 
ATOM   2665 C CG1 . VAL B 1 78  ? -32.032 16.019  -3.266  1.00 16.40 ? 103 VAL B CG1 1 
ATOM   2666 C CG2 . VAL B 1 78  ? -29.999 14.703  -3.869  1.00 16.53 ? 103 VAL B CG2 1 
ATOM   2667 N N   . ASN B 1 79  ? -31.164 13.658  -6.728  1.00 19.16 ? 104 ASN B N   1 
ATOM   2668 C CA  . ASN B 1 79  ? -31.086 13.106  -8.076  1.00 20.68 ? 104 ASN B CA  1 
ATOM   2669 C C   . ASN B 1 79  ? -29.991 12.065  -8.260  1.00 25.80 ? 104 ASN B C   1 
ATOM   2670 O O   . ASN B 1 79  ? -30.067 11.274  -9.209  1.00 32.71 ? 104 ASN B O   1 
ATOM   2671 C CB  . ASN B 1 79  ? -30.875 14.221  -9.102  1.00 19.96 ? 104 ASN B CB  1 
ATOM   2672 C CG  . ASN B 1 79  ? -29.631 15.014  -8.839  1.00 20.63 ? 104 ASN B CG  1 
ATOM   2673 O OD1 . ASN B 1 79  ? -29.233 15.200  -7.686  1.00 17.56 ? 104 ASN B OD1 1 
ATOM   2674 N ND2 . ASN B 1 79  ? -29.004 15.498  -9.900  1.00 28.38 ? 104 ASN B ND2 1 
ATOM   2675 N N   . TYR B 1 80  ? -28.978 12.047  -7.398  1.00 18.26 ? 105 TYR B N   1 
ATOM   2676 C CA  . TYR B 1 80  ? -27.882 11.084  -7.522  1.00 14.11 ? 105 TYR B CA  1 
ATOM   2677 C C   . TYR B 1 80  ? -27.384 10.774  -6.113  1.00 16.67 ? 105 TYR B C   1 
ATOM   2678 O O   . TYR B 1 80  ? -26.663 11.580  -5.520  1.00 18.73 ? 105 TYR B O   1 
ATOM   2679 C CB  . TYR B 1 80  ? -26.748 11.621  -8.381  1.00 15.05 ? 105 TYR B CB  1 
ATOM   2680 C CG  . TYR B 1 80  ? -25.670 10.586  -8.582  1.00 18.32 ? 105 TYR B CG  1 
ATOM   2681 C CD1 . TYR B 1 80  ? -25.945 9.413   -9.267  1.00 24.41 ? 105 TYR B CD1 1 
ATOM   2682 C CD2 . TYR B 1 80  ? -24.408 10.740  -8.019  1.00 16.89 ? 105 TYR B CD2 1 
ATOM   2683 C CE1 . TYR B 1 80  ? -24.987 8.444   -9.434  1.00 20.02 ? 105 TYR B CE1 1 
ATOM   2684 C CE2 . TYR B 1 80  ? -23.428 9.773   -8.190  1.00 17.40 ? 105 TYR B CE2 1 
ATOM   2685 C CZ  . TYR B 1 80  ? -23.733 8.625   -8.899  1.00 22.17 ? 105 TYR B CZ  1 
ATOM   2686 O OH  . TYR B 1 80  ? -22.793 7.643   -9.079  1.00 21.47 ? 105 TYR B OH  1 
ATOM   2687 N N   . ASN B 1 81  ? -27.748 9.608   -5.592  1.00 12.43 ? 106 ASN B N   1 
ATOM   2688 C CA  . ASN B 1 81  ? -27.487 9.278   -4.188  1.00 11.35 ? 106 ASN B CA  1 
ATOM   2689 C C   . ASN B 1 81  ? -27.166 7.798   -4.064  1.00 13.70 ? 106 ASN B C   1 
ATOM   2690 O O   . ASN B 1 81  ? -27.869 7.057   -3.377  1.00 12.76 ? 106 ASN B O   1 
ATOM   2691 C CB  . ASN B 1 81  ? -28.688 9.624   -3.303  1.00 23.30 ? 106 ASN B CB  1 
ATOM   2692 C CG  . ASN B 1 81  ? -29.828 10.274  -4.062  1.00 21.95 ? 106 ASN B CG  1 
ATOM   2693 O OD1 . ASN B 1 81  ? -29.836 11.480  -4.279  1.00 26.12 ? 106 ASN B OD1 1 
ATOM   2694 N ND2 . ASN B 1 81  ? -30.802 9.474   -4.460  1.00 28.92 ? 106 ASN B ND2 1 
ATOM   2695 N N   . PRO B 1 82  ? -26.092 7.329   -4.709  1.00 9.83  ? 107 PRO B N   1 
ATOM   2696 C CA  . PRO B 1 82  ? -25.838 5.880   -4.721  1.00 15.94 ? 107 PRO B CA  1 
ATOM   2697 C C   . PRO B 1 82  ? -25.566 5.298   -3.348  1.00 14.52 ? 107 PRO B C   1 
ATOM   2698 O O   . PRO B 1 82  ? -25.905 4.131   -3.110  1.00 16.57 ? 107 PRO B O   1 
ATOM   2699 C CB  . PRO B 1 82  ? -24.619 5.747   -5.645  1.00 18.84 ? 107 PRO B CB  1 
ATOM   2700 C CG  . PRO B 1 82  ? -23.936 7.046   -5.559  1.00 15.18 ? 107 PRO B CG  1 
ATOM   2701 C CD  . PRO B 1 82  ? -25.035 8.072   -5.417  1.00 11.72 ? 107 PRO B CD  1 
ATOM   2702 N N   . ILE B 1 83  ? -24.972 6.058   -2.431  1.00 9.44  ? 108 ILE B N   1 
ATOM   2703 C CA  . ILE B 1 83  ? -24.707 5.535   -1.093  1.00 7.64  ? 108 ILE B CA  1 
ATOM   2704 C C   . ILE B 1 83  ? -25.887 5.790   -0.160  1.00 9.91  ? 108 ILE B C   1 
ATOM   2705 O O   . ILE B 1 83  ? -26.345 4.880   0.547   1.00 10.94 ? 108 ILE B O   1 
ATOM   2706 C CB  . ILE B 1 83  ? -23.401 6.138   -0.532  1.00 9.79  ? 108 ILE B CB  1 
ATOM   2707 C CG1 . ILE B 1 83  ? -22.266 6.023   -1.550  1.00 9.09  ? 108 ILE B CG1 1 
ATOM   2708 C CG2 . ILE B 1 83  ? -23.003 5.458   0.769   1.00 9.43  ? 108 ILE B CG2 1 
ATOM   2709 C CD1 . ILE B 1 83  ? -22.050 4.604   -2.086  1.00 12.10 ? 108 ILE B CD1 1 
ATOM   2710 N N   . ALA B 1 84  ? -26.408 7.023   -0.157  1.00 10.45 ? 109 ALA B N   1 
ATOM   2711 C CA  . ALA B 1 84  ? -27.458 7.362   0.795   1.00 8.38  ? 109 ALA B CA  1 
ATOM   2712 C C   . ALA B 1 84  ? -28.726 6.552   0.563   1.00 11.86 ? 109 ALA B C   1 
ATOM   2713 O O   . ALA B 1 84  ? -29.460 6.278   1.519   1.00 12.27 ? 109 ALA B O   1 
ATOM   2714 C CB  . ALA B 1 84  ? -27.766 8.862   0.738   1.00 12.52 ? 109 ALA B CB  1 
ATOM   2715 N N   A GLU B 1 85  ? -29.017 6.149   -0.677  0.74 13.08 ? 110 GLU B N   1 
ATOM   2716 N N   B GLU B 1 85  ? -29.001 6.168   -0.691  0.26 13.03 ? 110 GLU B N   1 
ATOM   2717 C CA  A GLU B 1 85  ? -30.269 5.422   -0.855  0.74 12.13 ? 110 GLU B CA  1 
ATOM   2718 C CA  B GLU B 1 85  ? -30.192 5.375   -0.986  0.26 12.46 ? 110 GLU B CA  1 
ATOM   2719 C C   A GLU B 1 85  ? -30.220 4.036   -0.215  0.74 12.84 ? 110 GLU B C   1 
ATOM   2720 C C   B GLU B 1 85  ? -30.201 4.070   -0.202  0.26 12.88 ? 110 GLU B C   1 
ATOM   2721 O O   A GLU B 1 85  ? -31.281 3.466   0.079   0.74 15.90 ? 110 GLU B O   1 
ATOM   2722 O O   B GLU B 1 85  ? -31.270 3.584   0.189   0.26 15.69 ? 110 GLU B O   1 
ATOM   2723 C CB  A GLU B 1 85  ? -30.634 5.321   -2.334  0.74 13.59 ? 110 GLU B CB  1 
ATOM   2724 C CB  B GLU B 1 85  ? -30.270 5.080   -2.485  0.26 15.27 ? 110 GLU B CB  1 
ATOM   2725 C CG  A GLU B 1 85  ? -29.759 4.389   -3.127  0.74 12.41 ? 110 GLU B CG  1 
ATOM   2726 C CG  B GLU B 1 85  ? -30.894 6.185   -3.316  0.26 17.40 ? 110 GLU B CG  1 
ATOM   2727 C CD  A GLU B 1 85  ? -30.132 4.376   -4.598  0.74 18.28 ? 110 GLU B CD  1 
ATOM   2728 C CD  B GLU B 1 85  ? -30.652 5.998   -4.801  0.26 16.88 ? 110 GLU B CD  1 
ATOM   2729 O OE1 A GLU B 1 85  ? -31.106 5.065   -4.972  0.74 20.61 ? 110 GLU B OE1 1 
ATOM   2730 O OE1 B GLU B 1 85  ? -30.028 4.982   -5.180  0.26 20.64 ? 110 GLU B OE1 1 
ATOM   2731 O OE2 A GLU B 1 85  ? -29.448 3.688   -5.374  0.74 19.97 ? 110 GLU B OE2 1 
ATOM   2732 O OE2 B GLU B 1 85  ? -31.080 6.867   -5.590  0.26 22.39 ? 110 GLU B OE2 1 
ATOM   2733 N N   . LYS B 1 86  ? -29.022 3.498   0.044   1.00 11.41 ? 111 LYS B N   1 
ATOM   2734 C CA  . LYS B 1 86  ? -28.924 2.235   0.768   1.00 12.39 ? 111 LYS B CA  1 
ATOM   2735 C C   . LYS B 1 86  ? -29.265 2.380   2.244   1.00 13.55 ? 111 LYS B C   1 
ATOM   2736 O O   . LYS B 1 86  ? -29.482 1.368   2.923   1.00 13.34 ? 111 LYS B O   1 
ATOM   2737 C CB  . LYS B 1 86  ? -27.513 1.674   0.653   1.00 14.29 ? 111 LYS B CB  1 
ATOM   2738 C CG  . LYS B 1 86  ? -27.085 1.287   -0.736  1.00 18.55 ? 111 LYS B CG  1 
ATOM   2739 C CD  . LYS B 1 86  ? -25.792 0.529   -0.594  0.86 32.11 ? 111 LYS B CD  1 
ATOM   2740 C CE  . LYS B 1 86  ? -24.625 1.358   -1.052  1.00 24.79 ? 111 LYS B CE  1 
ATOM   2741 N NZ  . LYS B 1 86  ? -23.490 0.491   -1.427  1.00 20.28 ? 111 LYS B NZ  1 
ATOM   2742 N N   . HIS B 1 87  ? -29.285 3.608   2.763   1.00 12.66 ? 112 HIS B N   1 
ATOM   2743 C CA  . HIS B 1 87  ? -29.499 3.857   4.183   1.00 13.93 ? 112 HIS B CA  1 
ATOM   2744 C C   . HIS B 1 87  ? -30.781 4.614   4.478   1.00 13.97 ? 112 HIS B C   1 
ATOM   2745 O O   . HIS B 1 87  ? -30.945 5.117   5.598   1.00 16.04 ? 112 HIS B O   1 
ATOM   2746 C CB  . HIS B 1 87  ? -28.300 4.600   4.784   1.00 15.36 ? 112 HIS B CB  1 
ATOM   2747 C CG  . HIS B 1 87  ? -26.991 3.953   4.478   1.00 15.46 ? 112 HIS B CG  1 
ATOM   2748 N ND1 . HIS B 1 87  ? -26.452 2.969   5.279   1.00 29.63 ? 112 HIS B ND1 1 
ATOM   2749 C CD2 . HIS B 1 87  ? -26.115 4.134   3.465   1.00 13.17 ? 112 HIS B CD2 1 
ATOM   2750 C CE1 . HIS B 1 87  ? -25.301 2.569   4.768   1.00 37.13 ? 112 HIS B CE1 1 
ATOM   2751 N NE2 . HIS B 1 87  ? -25.072 3.263   3.668   1.00 23.39 ? 112 HIS B NE2 1 
ATOM   2752 N N   A VAL B 1 88  ? -31.698 4.711   3.515   0.62 10.71 ? 113 VAL B N   1 
ATOM   2753 N N   B VAL B 1 88  ? -31.697 4.711   3.513   0.38 10.79 ? 113 VAL B N   1 
ATOM   2754 C CA  A VAL B 1 88  ? -32.969 5.377   3.768   0.62 12.66 ? 113 VAL B CA  1 
ATOM   2755 C CA  B VAL B 1 88  ? -32.974 5.358   3.777   0.38 12.71 ? 113 VAL B CA  1 
ATOM   2756 C C   A VAL B 1 88  ? -33.707 4.651   4.885   0.62 12.02 ? 113 VAL B C   1 
ATOM   2757 C C   B VAL B 1 88  ? -33.669 4.646   4.926   0.38 12.07 ? 113 VAL B C   1 
ATOM   2758 O O   A VAL B 1 88  ? -33.698 3.414   4.958   0.62 13.91 ? 113 VAL B O   1 
ATOM   2759 O O   B VAL B 1 88  ? -33.583 3.418   5.068   0.38 14.06 ? 113 VAL B O   1 
ATOM   2760 C CB  A VAL B 1 88  ? -33.798 5.430   2.474   0.62 13.77 ? 113 VAL B CB  1 
ATOM   2761 C CB  B VAL B 1 88  ? -33.850 5.372   2.514   0.38 13.88 ? 113 VAL B CB  1 
ATOM   2762 C CG1 A VAL B 1 88  ? -35.193 5.965   2.746   0.62 16.45 ? 113 VAL B CG1 1 
ATOM   2763 C CG1 B VAL B 1 88  ? -33.239 6.273   1.470   0.38 22.39 ? 113 VAL B CG1 1 
ATOM   2764 C CG2 A VAL B 1 88  ? -33.098 6.288   1.456   0.62 23.02 ? 113 VAL B CG2 1 
ATOM   2765 C CG2 B VAL B 1 88  ? -34.032 3.963   1.975   0.38 13.39 ? 113 VAL B CG2 1 
ATOM   2766 N N   . ASN B 1 89  ? -34.345 5.429   5.768   1.00 16.64 ? 114 ASN B N   1 
ATOM   2767 C CA  . ASN B 1 89  ? -34.985 4.984   7.007   1.00 13.19 ? 114 ASN B CA  1 
ATOM   2768 C C   . ASN B 1 89  ? -33.975 4.506   8.041   1.00 18.23 ? 114 ASN B C   1 
ATOM   2769 O O   . ASN B 1 89  ? -34.363 3.956   9.073   1.00 18.99 ? 114 ASN B O   1 
ATOM   2770 C CB  . ASN B 1 89  ? -36.049 3.901   6.761   1.00 16.16 ? 114 ASN B CB  1 
ATOM   2771 C CG  . ASN B 1 89  ? -37.231 4.429   5.997   1.00 13.60 ? 114 ASN B CG  1 
ATOM   2772 O OD1 . ASN B 1 89  ? -37.737 5.516   6.292   1.00 18.01 ? 114 ASN B OD1 1 
ATOM   2773 N ND2 . ASN B 1 89  ? -37.661 3.688   4.971   1.00 16.03 ? 114 ASN B ND2 1 
ATOM   2774 N N   . GLY B 1 90  ? -32.681 4.728   7.804   1.00 16.52 ? 115 GLY B N   1 
ATOM   2775 C CA  . GLY B 1 90  ? -31.613 4.431   8.729   1.00 14.08 ? 115 GLY B CA  1 
ATOM   2776 C C   . GLY B 1 90  ? -30.770 5.673   8.965   1.00 9.75  ? 115 GLY B C   1 
ATOM   2777 O O   . GLY B 1 90  ? -31.252 6.804   8.862   1.00 15.00 ? 115 GLY B O   1 
ATOM   2778 N N   . THR B 1 91  ? -29.499 5.447   9.305   1.00 13.16 ? 116 THR B N   1 
ATOM   2779 C CA  . THR B 1 91  ? -28.589 6.551   9.581   1.00 14.84 ? 116 THR B CA  1 
ATOM   2780 C C   . THR B 1 91  ? -27.256 6.335   8.885   1.00 12.25 ? 116 THR B C   1 
ATOM   2781 O O   . THR B 1 91  ? -26.909 5.229   8.466   1.00 14.07 ? 116 THR B O   1 
ATOM   2782 C CB  . THR B 1 91  ? -28.318 6.743   11.083  1.00 16.32 ? 116 THR B CB  1 
ATOM   2783 O OG1 . THR B 1 91  ? -27.753 5.547   11.636  1.00 17.84 ? 116 THR B OG1 1 
ATOM   2784 C CG2 . THR B 1 91  ? -29.601 7.106   11.829  1.00 17.05 ? 116 THR B CG2 1 
ATOM   2785 N N   . MET B 1 92  ? -26.511 7.429   8.777   1.00 12.74 ? 117 MET B N   1 
ATOM   2786 C CA  . MET B 1 92  ? -25.148 7.449   8.274   1.00 10.30 ? 117 MET B CA  1 
ATOM   2787 C C   . MET B 1 92  ? -24.385 8.397   9.186   1.00 11.15 ? 117 MET B C   1 
ATOM   2788 O O   . MET B 1 92  ? -24.932 9.425   9.588   1.00 12.07 ? 117 MET B O   1 
ATOM   2789 C CB  . MET B 1 92  ? -25.136 7.961   6.825   1.00 13.21 ? 117 MET B CB  1 
ATOM   2790 C CG  . MET B 1 92  ? -25.487 6.905   5.784   1.00 10.88 ? 117 MET B CG  1 
ATOM   2791 S SD  . MET B 1 92  ? -25.515 7.608   4.131   1.00 12.90 ? 117 MET B SD  1 
ATOM   2792 C CE  . MET B 1 92  ? -23.766 7.774   3.771   1.00 12.71 ? 117 MET B CE  1 
ATOM   2793 N N   . THR B 1 93  ? -23.149 8.061   9.543   1.00 9.90  ? 118 THR B N   1 
ATOM   2794 C CA  . THR B 1 93  ? -22.371 9.015   10.324  1.00 10.65 ? 118 THR B CA  1 
ATOM   2795 C C   . THR B 1 93  ? -21.842 10.138  9.436   1.00 10.56 ? 118 THR B C   1 
ATOM   2796 O O   . THR B 1 93  ? -21.812 10.032  8.209   1.00 9.31  ? 118 THR B O   1 
ATOM   2797 C CB  . THR B 1 93  ? -21.190 8.355   11.018  1.00 8.74  ? 118 THR B CB  1 
ATOM   2798 O OG1 . THR B 1 93  ? -20.221 7.951   10.031  1.00 10.98 ? 118 THR B OG1 1 
ATOM   2799 C CG2 . THR B 1 93  ? -21.646 7.150   11.834  1.00 12.04 ? 118 THR B CG2 1 
ATOM   2800 N N   . LEU B 1 94  ? -21.406 11.227  10.073  1.00 8.25  ? 119 LEU B N   1 
ATOM   2801 C CA  . LEU B 1 94  ? -20.839 12.321  9.291   1.00 7.83  ? 119 LEU B CA  1 
ATOM   2802 C C   . LEU B 1 94  ? -19.584 11.887  8.544   1.00 9.33  ? 119 LEU B C   1 
ATOM   2803 O O   . LEU B 1 94  ? -19.318 12.399  7.451   1.00 8.70  ? 119 LEU B O   1 
ATOM   2804 C CB  . LEU B 1 94  ? -20.553 13.531  10.183  1.00 9.89  ? 119 LEU B CB  1 
ATOM   2805 C CG  . LEU B 1 94  ? -21.819 14.321  10.503  1.00 8.75  ? 119 LEU B CG  1 
ATOM   2806 C CD1 . LEU B 1 94  ? -21.543 15.311  11.632  1.00 11.15 ? 119 LEU B CD1 1 
ATOM   2807 C CD2 . LEU B 1 94  ? -22.350 15.048  9.276   1.00 10.75 ? 119 LEU B CD2 1 
ATOM   2808 N N   . ALA B 1 95  ? -18.809 10.939  9.085   1.00 8.68  ? 120 ALA B N   1 
ATOM   2809 C CA  . ALA B 1 95  ? -17.684 10.420  8.312   1.00 9.45  ? 120 ALA B CA  1 
ATOM   2810 C C   . ALA B 1 95  ? -18.174 9.670   7.075   1.00 10.26 ? 120 ALA B C   1 
ATOM   2811 O O   . ALA B 1 95  ? -17.631 9.844   5.977   1.00 8.82  ? 120 ALA B O   1 
ATOM   2812 C CB  . ALA B 1 95  ? -16.813 9.517   9.183   1.00 10.41 ? 120 ALA B CB  1 
ATOM   2813 N N   . GLU B 1 96  ? -19.210 8.845   7.232   1.00 10.22 ? 121 GLU B N   1 
ATOM   2814 C CA  . GLU B 1 96  ? -19.757 8.114   6.093   1.00 9.77  ? 121 GLU B CA  1 
ATOM   2815 C C   . GLU B 1 96  ? -20.316 9.065   5.044   1.00 10.68 ? 121 GLU B C   1 
ATOM   2816 O O   . GLU B 1 96  ? -20.162 8.833   3.838   1.00 9.73  ? 121 GLU B O   1 
ATOM   2817 C CB  . GLU B 1 96  ? -20.862 7.173   6.565   1.00 8.20  ? 121 GLU B CB  1 
ATOM   2818 C CG  . GLU B 1 96  ? -20.392 5.947   7.331   1.00 8.84  ? 121 GLU B CG  1 
ATOM   2819 C CD  . GLU B 1 96  ? -21.549 5.044   7.727   1.00 13.01 ? 121 GLU B CD  1 
ATOM   2820 O OE1 . GLU B 1 96  ? -22.361 5.443   8.586   1.00 13.69 ? 121 GLU B OE1 1 
ATOM   2821 O OE2 . GLU B 1 96  ? -21.668 3.948   7.140   1.00 16.22 ? 121 GLU B OE2 1 
ATOM   2822 N N   . LEU B 1 97  ? -21.026 10.109  5.488   1.00 8.59  ? 122 LEU B N   1 
ATOM   2823 C CA  . LEU B 1 97  ? -21.541 11.110  4.559   1.00 5.57  ? 122 LEU B CA  1 
ATOM   2824 C C   . LEU B 1 97  ? -20.409 11.854  3.847   1.00 8.20  ? 122 LEU B C   1 
ATOM   2825 O O   . LEU B 1 97  ? -20.485 12.106  2.638   1.00 7.70  ? 122 LEU B O   1 
ATOM   2826 C CB  . LEU B 1 97  ? -22.442 12.081  5.309   1.00 7.29  ? 122 LEU B CB  1 
ATOM   2827 C CG  . LEU B 1 97  ? -23.719 11.421  5.796   1.00 6.31  ? 122 LEU B CG  1 
ATOM   2828 C CD1 . LEU B 1 97  ? -24.315 12.196  6.961   1.00 10.86 ? 122 LEU B CD1 1 
ATOM   2829 C CD2 . LEU B 1 97  ? -24.715 11.345  4.646   1.00 9.56  ? 122 LEU B CD2 1 
ATOM   2830 N N   . SER B 1 98  ? -19.349 12.209  4.575   1.00 7.35  ? 123 SER B N   1 
ATOM   2831 C CA  . SER B 1 98  ? -18.199 12.859  3.942   1.00 8.62  ? 123 SER B CA  1 
ATOM   2832 C C   . SER B 1 98  ? -17.566 11.961  2.891   1.00 8.37  ? 123 SER B C   1 
ATOM   2833 O O   . SER B 1 98  ? -17.271 12.405  1.774   1.00 9.16  ? 123 SER B O   1 
ATOM   2834 C CB  . SER B 1 98  ? -17.175 13.243  5.002   1.00 10.00 ? 123 SER B CB  1 
ATOM   2835 O OG  . SER B 1 98  ? -17.702 14.198  5.911   1.00 9.73  ? 123 SER B OG  1 
ATOM   2836 N N   . ALA B 1 99  ? -17.340 10.691  3.233   1.00 8.18  ? 124 ALA B N   1 
ATOM   2837 C CA  . ALA B 1 99  ? -16.731 9.769   2.279   1.00 8.08  ? 124 ALA B CA  1 
ATOM   2838 C C   . ALA B 1 99  ? -17.627 9.562   1.067   1.00 8.94  ? 124 ALA B C   1 
ATOM   2839 O O   . ALA B 1 99  ? -17.141 9.505   -0.068  1.00 9.35  ? 124 ALA B O   1 
ATOM   2840 C CB  . ALA B 1 99  ? -16.437 8.433   2.966   1.00 9.38  ? 124 ALA B CB  1 
ATOM   2841 N N   . ALA B 1 100 ? -18.938 9.452   1.280   1.00 6.78  ? 125 ALA B N   1 
ATOM   2842 C CA  . ALA B 1 100 ? -19.840 9.240   0.153   1.00 7.30  ? 125 ALA B CA  1 
ATOM   2843 C C   . ALA B 1 100 ? -19.914 10.463  -0.750  1.00 8.13  ? 125 ALA B C   1 
ATOM   2844 O O   . ALA B 1 100 ? -19.941 10.336  -1.986  1.00 8.51  ? 125 ALA B O   1 
ATOM   2845 C CB  . ALA B 1 100 ? -21.228 8.870   0.671   1.00 8.84  ? 125 ALA B CB  1 
ATOM   2846 N N   . ALA B 1 101 ? -19.961 11.656  -0.153  1.00 7.28  ? 126 ALA B N   1 
ATOM   2847 C CA  . ALA B 1 101 ? -19.951 12.879  -0.949  1.00 6.84  ? 126 ALA B CA  1 
ATOM   2848 C C   . ALA B 1 101 ? -18.676 12.981  -1.773  1.00 7.91  ? 126 ALA B C   1 
ATOM   2849 O O   . ALA B 1 101 ? -18.728 13.269  -2.970  1.00 8.65  ? 126 ALA B O   1 
ATOM   2850 C CB  . ALA B 1 101 ? -20.106 14.104  -0.045  1.00 8.77  ? 126 ALA B CB  1 
ATOM   2851 N N   . LEU B 1 102 ? -17.517 12.742  -1.150  1.00 7.72  ? 127 LEU B N   1 
ATOM   2852 C CA  . LEU B 1 102 ? -16.253 13.004  -1.836  1.00 7.28  ? 127 LEU B CA  1 
ATOM   2853 C C   . LEU B 1 102 ? -15.911 11.897  -2.821  1.00 8.63  ? 127 LEU B C   1 
ATOM   2854 O O   . LEU B 1 102 ? -15.441 12.174  -3.934  1.00 9.34  ? 127 LEU B O   1 
ATOM   2855 C CB  . LEU B 1 102 ? -15.120 13.174  -0.813  1.00 8.21  ? 127 LEU B CB  1 
ATOM   2856 C CG  . LEU B 1 102 ? -15.129 14.430  0.068   1.00 6.27  ? 127 LEU B CG  1 
ATOM   2857 C CD1 . LEU B 1 102 ? -13.982 14.393  1.079   1.00 10.45 ? 127 LEU B CD1 1 
ATOM   2858 C CD2 . LEU B 1 102 ? -15.060 15.696  -0.792  1.00 9.59  ? 127 LEU B CD2 1 
ATOM   2859 N N   . GLN B 1 103 ? -16.121 10.637  -2.437  1.00 8.72  ? 128 GLN B N   1 
ATOM   2860 C CA  . GLN B 1 103 ? -15.605 9.550   -3.258  1.00 9.88  ? 128 GLN B CA  1 
ATOM   2861 C C   . GLN B 1 103 ? -16.607 9.024   -4.272  1.00 8.35  ? 128 GLN B C   1 
ATOM   2862 O O   . GLN B 1 103 ? -16.184 8.425   -5.270  1.00 9.45  ? 128 GLN B O   1 
ATOM   2863 C CB  . GLN B 1 103 ? -15.115 8.409   -2.371  1.00 10.63 ? 128 GLN B CB  1 
ATOM   2864 C CG  . GLN B 1 103 ? -14.048 8.851   -1.378  1.00 10.02 ? 128 GLN B CG  1 
ATOM   2865 C CD  . GLN B 1 103 ? -13.407 7.687   -0.651  1.00 9.64  ? 128 GLN B CD  1 
ATOM   2866 O OE1 . GLN B 1 103 ? -14.085 6.730   -0.275  1.00 11.21 ? 128 GLN B OE1 1 
ATOM   2867 N NE2 . GLN B 1 103 ? -12.094 7.766   -0.435  1.00 8.76  ? 128 GLN B NE2 1 
ATOM   2868 N N   . TYR B 1 104 ? -17.911 9.230   -4.047  1.00 9.04  ? 129 TYR B N   1 
ATOM   2869 C CA  . TYR B 1 104 ? -18.942 8.808   -4.980  1.00 9.17  ? 129 TYR B CA  1 
ATOM   2870 C C   . TYR B 1 104 ? -19.773 9.965   -5.503  1.00 11.87 ? 129 TYR B C   1 
ATOM   2871 O O   . TYR B 1 104 ? -20.645 9.750   -6.352  1.00 12.54 ? 129 TYR B O   1 
ATOM   2872 C CB  . TYR B 1 104 ? -19.844 7.765   -4.306  1.00 13.23 ? 129 TYR B CB  1 
ATOM   2873 C CG  . TYR B 1 104 ? -19.097 6.486   -4.006  1.00 10.95 ? 129 TYR B CG  1 
ATOM   2874 C CD1 . TYR B 1 104 ? -18.397 6.316   -2.819  1.00 10.23 ? 129 TYR B CD1 1 
ATOM   2875 C CD2 . TYR B 1 104 ? -19.071 5.456   -4.934  1.00 12.39 ? 129 TYR B CD2 1 
ATOM   2876 C CE1 . TYR B 1 104 ? -17.692 5.152   -2.565  1.00 10.06 ? 129 TYR B CE1 1 
ATOM   2877 C CE2 . TYR B 1 104 ? -18.397 4.301   -4.681  1.00 9.59  ? 129 TYR B CE2 1 
ATOM   2878 C CZ  . TYR B 1 104 ? -17.707 4.151   -3.499  1.00 10.26 ? 129 TYR B CZ  1 
ATOM   2879 O OH  . TYR B 1 104 ? -17.014 2.982   -3.249  1.00 15.74 ? 129 TYR B OH  1 
ATOM   2880 N N   . SER B 1 105 ? -19.528 11.179  -5.013  1.00 9.61  ? 130 SER B N   1 
ATOM   2881 C CA  . SER B 1 105 ? -20.243 12.386  -5.433  1.00 10.47 ? 130 SER B CA  1 
ATOM   2882 C C   . SER B 1 105 ? -21.729 12.284  -5.086  1.00 9.18  ? 130 SER B C   1 
ATOM   2883 O O   . SER B 1 105 ? -22.594 12.741  -5.834  1.00 11.16 ? 130 SER B O   1 
ATOM   2884 C CB  . SER B 1 105 ? -20.032 12.687  -6.919  1.00 11.24 ? 130 SER B CB  1 
ATOM   2885 O OG  . SER B 1 105 ? -20.076 14.097  -7.098  1.00 11.27 ? 130 SER B OG  1 
ATOM   2886 N N   . ASP B 1 106 ? -22.025 11.671  -3.932  1.00 8.36  ? 131 ASP B N   1 
ATOM   2887 C CA  . ASP B 1 106 ? -23.400 11.484  -3.472  1.00 8.05  ? 131 ASP B CA  1 
ATOM   2888 C C   . ASP B 1 106 ? -24.013 12.824  -3.059  1.00 8.72  ? 131 ASP B C   1 
ATOM   2889 O O   . ASP B 1 106 ? -23.495 13.514  -2.172  1.00 9.72  ? 131 ASP B O   1 
ATOM   2890 C CB  . ASP B 1 106 ? -23.420 10.477  -2.318  1.00 8.31  ? 131 ASP B CB  1 
ATOM   2891 C CG  . ASP B 1 106 ? -24.837 10.066  -1.905  1.00 10.28 ? 131 ASP B CG  1 
ATOM   2892 O OD1 . ASP B 1 106 ? -25.634 10.948  -1.551  1.00 8.67  ? 131 ASP B OD1 1 
ATOM   2893 O OD2 . ASP B 1 106 ? -25.128 8.843   -1.905  1.00 11.92 ? 131 ASP B OD2 1 
ATOM   2894 N N   . ASN B 1 107 ? -25.123 13.188  -3.696  1.00 8.81  ? 132 ASN B N   1 
ATOM   2895 C CA  . ASN B 1 107 ? -25.714 14.513  -3.495  1.00 7.93  ? 132 ASN B CA  1 
ATOM   2896 C C   . ASN B 1 107 ? -26.540 14.603  -2.221  1.00 9.85  ? 132 ASN B C   1 
ATOM   2897 O O   . ASN B 1 107 ? -26.607 15.676  -1.609  1.00 8.89  ? 132 ASN B O   1 
ATOM   2898 C CB  . ASN B 1 107 ? -26.589 14.875  -4.688  1.00 8.26  ? 132 ASN B CB  1 
ATOM   2899 C CG  . ASN B 1 107 ? -25.790 15.327  -5.880  1.00 10.68 ? 132 ASN B CG  1 
ATOM   2900 O OD1 . ASN B 1 107 ? -24.581 15.590  -5.785  1.00 12.85 ? 132 ASN B OD1 1 
ATOM   2901 N ND2 . ASN B 1 107 ? -26.458 15.407  -7.036  1.00 14.34 ? 132 ASN B ND2 1 
ATOM   2902 N N   . THR B 1 108 ? -27.206 13.517  -1.826  1.00 9.28  ? 133 THR B N   1 
ATOM   2903 C CA  . THR B 1 108 ? -27.874 13.515  -0.534  1.00 10.27 ? 133 THR B CA  1 
ATOM   2904 C C   . THR B 1 108 ? -26.855 13.687  0.582   1.00 7.67  ? 133 THR B C   1 
ATOM   2905 O O   . THR B 1 108 ? -27.090 14.429  1.544   1.00 8.58  ? 133 THR B O   1 
ATOM   2906 C CB  . THR B 1 108 ? -28.665 12.217  -0.348  1.00 11.12 ? 133 THR B CB  1 
ATOM   2907 O OG1 . THR B 1 108 ? -29.705 12.152  -1.332  1.00 12.26 ? 133 THR B OG1 1 
ATOM   2908 C CG2 . THR B 1 108 ? -29.273 12.155  1.047   1.00 10.38 ? 133 THR B CG2 1 
ATOM   2909 N N   . ALA B 1 109 ? -25.704 13.013  0.466   1.00 7.64  ? 134 ALA B N   1 
ATOM   2910 C CA  . ALA B 1 109 ? -24.671 13.152  1.485   1.00 8.13  ? 134 ALA B CA  1 
ATOM   2911 C C   . ALA B 1 109 ? -24.185 14.592  1.580   1.00 7.62  ? 134 ALA B C   1 
ATOM   2912 O O   . ALA B 1 109 ? -24.033 15.127  2.686   1.00 9.00  ? 134 ALA B O   1 
ATOM   2913 C CB  . ALA B 1 109 ? -23.513 12.199  1.182   1.00 8.10  ? 134 ALA B CB  1 
ATOM   2914 N N   . MET B 1 110 ? -23.979 15.252  0.433   1.00 7.63  ? 135 MET B N   1 
ATOM   2915 C CA  . MET B 1 110 ? -23.649 16.672  0.436   1.00 8.02  ? 135 MET B CA  1 
ATOM   2916 C C   . MET B 1 110 ? -24.678 17.477  1.215   1.00 10.47 ? 135 MET B C   1 
ATOM   2917 O O   . MET B 1 110 ? -24.318 18.346  2.020   1.00 9.11  ? 135 MET B O   1 
ATOM   2918 C CB  . MET B 1 110 ? -23.555 17.205  -1.005  1.00 6.94  ? 135 MET B CB  1 
ATOM   2919 C CG  . MET B 1 110 ? -23.245 18.711  -1.125  1.00 8.40  ? 135 MET B CG  1 
ATOM   2920 S SD  . MET B 1 110 ? -21.857 19.342  -0.137  1.00 9.37  ? 135 MET B SD  1 
ATOM   2921 C CE  . MET B 1 110 ? -21.475 20.798  -1.116  1.00 9.96  ? 135 MET B CE  1 
ATOM   2922 N N   . ASN B 1 111 ? -25.976 17.219  0.977   1.00 6.98  ? 136 ASN B N   1 
ATOM   2923 C CA  . ASN B 1 111 ? -26.997 18.017  1.655   1.00 7.00  ? 136 ASN B CA  1 
ATOM   2924 C C   . ASN B 1 111 ? -26.945 17.825  3.162   1.00 8.80  ? 136 ASN B C   1 
ATOM   2925 O O   . ASN B 1 111 ? -27.252 18.764  3.917   1.00 10.89 ? 136 ASN B O   1 
ATOM   2926 C CB  . ASN B 1 111 ? -28.386 17.700  1.096   1.00 8.05  ? 136 ASN B CB  1 
ATOM   2927 C CG  . ASN B 1 111 ? -28.653 18.428  -0.220  1.00 9.11  ? 136 ASN B CG  1 
ATOM   2928 O OD1 . ASN B 1 111 ? -27.852 19.265  -0.646  1.00 9.70  ? 136 ASN B OD1 1 
ATOM   2929 N ND2 . ASN B 1 111 ? -29.756 18.096  -0.873  1.00 11.22 ? 136 ASN B ND2 1 
ATOM   2930 N N   . LYS B 1 112 ? -26.537 16.644  3.630   1.00 8.22  ? 137 LYS B N   1 
ATOM   2931 C CA  . LYS B 1 112 ? -26.393 16.449  5.071   1.00 9.46  ? 137 LYS B CA  1 
ATOM   2932 C C   . LYS B 1 112 ? -25.188 17.209  5.617   1.00 9.29  ? 137 LYS B C   1 
ATOM   2933 O O   . LYS B 1 112 ? -25.238 17.735  6.736   1.00 8.71  ? 137 LYS B O   1 
ATOM   2934 C CB  . LYS B 1 112 ? -26.285 14.958  5.396   1.00 9.28  ? 137 LYS B CB  1 
ATOM   2935 C CG  . LYS B 1 112 ? -27.556 14.151  5.139   1.00 8.87  ? 137 LYS B CG  1 
ATOM   2936 C CD  . LYS B 1 112 ? -28.789 14.819  5.731   1.00 12.92 ? 137 LYS B CD  1 
ATOM   2937 C CE  . LYS B 1 112 ? -30.035 13.994  5.404   1.00 15.89 ? 137 LYS B CE  1 
ATOM   2938 N NZ  . LYS B 1 112 ? -31.185 14.351  6.287   1.00 24.77 ? 137 LYS B NZ  1 
ATOM   2939 N N   . LEU B 1 113 ? -24.102 17.299  4.845   1.00 7.75  ? 138 LEU B N   1 
ATOM   2940 C CA  . LEU B 1 113 ? -22.977 18.140  5.266   1.00 7.48  ? 138 LEU B CA  1 
ATOM   2941 C C   . LEU B 1 113 ? -23.399 19.604  5.333   1.00 8.12  ? 138 LEU B C   1 
ATOM   2942 O O   . LEU B 1 113 ? -23.080 20.308  6.301   1.00 9.35  ? 138 LEU B O   1 
ATOM   2943 C CB  . LEU B 1 113 ? -21.786 17.982  4.313   1.00 8.01  ? 138 LEU B CB  1 
ATOM   2944 C CG  . LEU B 1 113 ? -21.237 16.564  4.126   1.00 7.82  ? 138 LEU B CG  1 
ATOM   2945 C CD1 . LEU B 1 113 ? -20.125 16.548  3.108   1.00 10.30 ? 138 LEU B CD1 1 
ATOM   2946 C CD2 . LEU B 1 113 ? -20.765 15.953  5.444   1.00 10.79 ? 138 LEU B CD2 1 
ATOM   2947 N N   . ILE B 1 114 ? -24.129 20.078  4.321   1.00 8.32  ? 139 ILE B N   1 
ATOM   2948 C CA  . ILE B 1 114 ? -24.580 21.466  4.317   1.00 8.72  ? 139 ILE B CA  1 
ATOM   2949 C C   . ILE B 1 114 ? -25.476 21.737  5.524   1.00 8.14  ? 139 ILE B C   1 
ATOM   2950 O O   . ILE B 1 114 ? -25.342 22.771  6.197   1.00 9.22  ? 139 ILE B O   1 
ATOM   2951 C CB  . ILE B 1 114 ? -25.298 21.793  2.988   1.00 7.46  ? 139 ILE B CB  1 
ATOM   2952 C CG1 . ILE B 1 114 ? -24.343 21.698  1.800   1.00 8.36  ? 139 ILE B CG1 1 
ATOM   2953 C CG2 . ILE B 1 114 ? -25.890 23.195  3.023   1.00 9.19  ? 139 ILE B CG2 1 
ATOM   2954 C CD1 . ILE B 1 114 ? -25.053 21.726  0.454   1.00 11.52 ? 139 ILE B CD1 1 
ATOM   2955 N N   . ALA B 1 115 ? -26.387 20.811  5.831   1.00 9.48  ? 140 ALA B N   1 
ATOM   2956 C CA  . ALA B 1 115 ? -27.277 21.015  6.975   1.00 8.59  ? 140 ALA B CA  1 
ATOM   2957 C C   . ALA B 1 115 ? -26.492 21.046  8.286   1.00 9.98  ? 140 ALA B C   1 
ATOM   2958 O O   . ALA B 1 115 ? -26.804 21.841  9.188   1.00 9.88  ? 140 ALA B O   1 
ATOM   2959 C CB  . ALA B 1 115 ? -28.346 19.923  7.017   1.00 10.92 ? 140 ALA B CB  1 
ATOM   2960 N N   . GLN B 1 116 ? -25.469 20.193  8.408   1.00 10.16 ? 141 GLN B N   1 
ATOM   2961 C CA  . GLN B 1 116 ? -24.604 20.189  9.587   1.00 9.80  ? 141 GLN B CA  1 
ATOM   2962 C C   . GLN B 1 116 ? -23.882 21.516  9.769   1.00 11.01 ? 141 GLN B C   1 
ATOM   2963 O O   . GLN B 1 116 ? -23.519 21.868  10.899  1.00 13.49 ? 141 GLN B O   1 
ATOM   2964 C CB  . GLN B 1 116 ? -23.617 19.017  9.484   1.00 10.86 ? 141 GLN B CB  1 
ATOM   2965 C CG  . GLN B 1 116 ? -22.436 19.005  10.485  1.00 9.36  ? 141 GLN B CG  1 
ATOM   2966 C CD  . GLN B 1 116 ? -22.870 18.957  11.939  1.00 12.45 ? 141 GLN B CD  1 
ATOM   2967 O OE1 . GLN B 1 116 ? -23.971 18.505  12.271  1.00 12.05 ? 141 GLN B OE1 1 
ATOM   2968 N NE2 . GLN B 1 116 ? -21.982 19.402  12.819  1.00 13.89 ? 141 GLN B NE2 1 
ATOM   2969 N N   . LEU B 1 117 ? -23.716 22.292  8.699   1.00 7.65  ? 142 LEU B N   1 
ATOM   2970 C CA  . LEU B 1 117 ? -23.050 23.584  8.761   1.00 10.12 ? 142 LEU B CA  1 
ATOM   2971 C C   . LEU B 1 117 ? -24.037 24.737  8.837   1.00 9.14  ? 142 LEU B C   1 
ATOM   2972 O O   . LEU B 1 117 ? -23.616 25.892  8.853   1.00 12.33 ? 142 LEU B O   1 
ATOM   2973 C CB  . LEU B 1 117 ? -22.122 23.749  7.556   1.00 9.33  ? 142 LEU B CB  1 
ATOM   2974 C CG  . LEU B 1 117 ? -21.076 22.626  7.487   1.00 13.56 ? 142 LEU B CG  1 
ATOM   2975 C CD1 . LEU B 1 117 ? -20.468 22.504  6.071   1.00 10.67 ? 142 LEU B CD1 1 
ATOM   2976 C CD2 . LEU B 1 117 ? -19.989 22.857  8.508   1.00 13.11 ? 142 LEU B CD2 1 
ATOM   2977 N N   . GLY B 1 118 ? -25.336 24.451  8.898   1.00 9.64  ? 143 GLY B N   1 
ATOM   2978 C CA  . GLY B 1 118 ? -26.323 25.500  9.031   1.00 11.69 ? 143 GLY B CA  1 
ATOM   2979 C C   . GLY B 1 118 ? -26.878 26.037  7.731   1.00 17.93 ? 143 GLY B C   1 
ATOM   2980 O O   . GLY B 1 118 ? -27.569 27.065  7.745   1.00 19.35 ? 143 GLY B O   1 
ATOM   2981 N N   . GLY B 1 119 ? -26.606 25.381  6.612   1.00 12.26 ? 144 GLY B N   1 
ATOM   2982 C CA  . GLY B 1 119 ? -27.074 25.850  5.335   1.00 8.83  ? 144 GLY B CA  1 
ATOM   2983 C C   . GLY B 1 119 ? -25.913 26.230  4.439   1.00 8.01  ? 144 GLY B C   1 
ATOM   2984 O O   . GLY B 1 119 ? -24.752 26.258  4.868   1.00 8.55  ? 144 GLY B O   1 
ATOM   2985 N N   . PRO B 1 120 ? -26.200 26.537  3.174   1.00 8.41  ? 145 PRO B N   1 
ATOM   2986 C CA  . PRO B 1 120 ? -25.108 26.875  2.241   1.00 9.39  ? 145 PRO B CA  1 
ATOM   2987 C C   . PRO B 1 120 ? -24.175 27.966  2.753   1.00 8.75  ? 145 PRO B C   1 
ATOM   2988 O O   . PRO B 1 120 ? -22.943 27.857  2.598   1.00 9.64  ? 145 PRO B O   1 
ATOM   2989 C CB  . PRO B 1 120 ? -25.874 27.291  0.971   1.00 10.59 ? 145 PRO B CB  1 
ATOM   2990 C CG  . PRO B 1 120 ? -27.157 26.474  1.037   1.00 11.02 ? 145 PRO B CG  1 
ATOM   2991 C CD  . PRO B 1 120 ? -27.515 26.454  2.509   1.00 8.84  ? 145 PRO B CD  1 
ATOM   2992 N N   . GLY B 1 121 ? -24.729 29.000  3.398   1.00 9.06  ? 146 GLY B N   1 
ATOM   2993 C CA  . GLY B 1 121 ? -23.935 30.074  3.974   1.00 8.59  ? 146 GLY B CA  1 
ATOM   2994 C C   . GLY B 1 121 ? -22.961 29.622  5.039   1.00 9.85  ? 146 GLY B C   1 
ATOM   2995 O O   . GLY B 1 121 ? -21.949 30.293  5.267   1.00 11.34 ? 146 GLY B O   1 
ATOM   2996 N N   . GLY B 1 122 ? -23.227 28.487  5.693   1.00 10.00 ? 147 GLY B N   1 
ATOM   2997 C CA  . GLY B 1 122 ? -22.243 27.942  6.610   1.00 10.38 ? 147 GLY B CA  1 
ATOM   2998 C C   . GLY B 1 122 ? -21.015 27.432  5.891   1.00 11.91 ? 147 GLY B C   1 
ATOM   2999 O O   . GLY B 1 122 ? -19.901 27.483  6.427   1.00 10.15 ? 147 GLY B O   1 
ATOM   3000 N N   . VAL B 1 123 ? -21.189 26.939  4.667   1.00 10.99 ? 148 VAL B N   1 
ATOM   3001 C CA  . VAL B 1 123 ? -20.033 26.532  3.884   1.00 8.59  ? 148 VAL B CA  1 
ATOM   3002 C C   . VAL B 1 123 ? -19.237 27.761  3.455   1.00 9.21  ? 148 VAL B C   1 
ATOM   3003 O O   . VAL B 1 123 ? -18.010 27.798  3.578   1.00 10.04 ? 148 VAL B O   1 
ATOM   3004 C CB  . VAL B 1 123 ? -20.472 25.684  2.674   1.00 9.61  ? 148 VAL B CB  1 
ATOM   3005 C CG1 . VAL B 1 123 ? -19.258 25.141  1.951   1.00 9.72  ? 148 VAL B CG1 1 
ATOM   3006 C CG2 . VAL B 1 123 ? -21.384 24.531  3.115   1.00 11.05 ? 148 VAL B CG2 1 
ATOM   3007 N N   . THR B 1 124 ? -19.933 28.788  2.958   1.00 9.38  ? 149 THR B N   1 
ATOM   3008 C CA  . THR B 1 124 ? -19.285 30.045  2.604   1.00 7.64  ? 149 THR B CA  1 
ATOM   3009 C C   . THR B 1 124 ? -18.541 30.637  3.794   1.00 8.85  ? 149 THR B C   1 
ATOM   3010 O O   . THR B 1 124 ? -17.413 31.129  3.647   1.00 10.34 ? 149 THR B O   1 
ATOM   3011 C CB  . THR B 1 124 ? -20.328 31.027  2.088   1.00 8.27  ? 149 THR B CB  1 
ATOM   3012 O OG1 . THR B 1 124 ? -21.061 30.419  1.015   1.00 9.83  ? 149 THR B OG1 1 
ATOM   3013 C CG2 . THR B 1 124 ? -19.650 32.307  1.616   1.00 9.27  ? 149 THR B CG2 1 
ATOM   3014 N N   . ALA B 1 125 ? -19.156 30.587  4.982   1.00 9.00  ? 150 ALA B N   1 
ATOM   3015 C CA  . ALA B 1 125 ? -18.502 31.129  6.170   1.00 8.51  ? 150 ALA B CA  1 
ATOM   3016 C C   . ALA B 1 125 ? -17.195 30.412  6.477   1.00 11.10 ? 150 ALA B C   1 
ATOM   3017 O O   . ALA B 1 125 ? -16.206 31.044  6.869   1.00 11.12 ? 150 ALA B O   1 
ATOM   3018 C CB  . ALA B 1 125 ? -19.443 31.038  7.370   1.00 8.64  ? 150 ALA B CB  1 
ATOM   3019 N N   . PHE B 1 126 ? -17.167 29.087  6.327   1.00 10.14 ? 151 PHE B N   1 
ATOM   3020 C CA  . PHE B 1 126 ? -15.909 28.375  6.523   1.00 9.59  ? 151 PHE B CA  1 
ATOM   3021 C C   . PHE B 1 126 ? -14.873 28.809  5.499   1.00 11.10 ? 151 PHE B C   1 
ATOM   3022 O O   . PHE B 1 126 ? -13.696 28.986  5.833   1.00 10.45 ? 151 PHE B O   1 
ATOM   3023 C CB  . PHE B 1 126 ? -16.130 26.864  6.451   1.00 9.13  ? 151 PHE B CB  1 
ATOM   3024 C CG  . PHE B 1 126 ? -14.855 26.080  6.431   1.00 8.93  ? 151 PHE B CG  1 
ATOM   3025 C CD1 . PHE B 1 126 ? -14.080 25.974  7.580   1.00 9.24  ? 151 PHE B CD1 1 
ATOM   3026 C CD2 . PHE B 1 126 ? -14.417 25.461  5.264   1.00 9.06  ? 151 PHE B CD2 1 
ATOM   3027 C CE1 . PHE B 1 126 ? -12.894 25.273  7.568   1.00 9.74  ? 151 PHE B CE1 1 
ATOM   3028 C CE2 . PHE B 1 126 ? -13.224 24.751  5.254   1.00 9.44  ? 151 PHE B CE2 1 
ATOM   3029 C CZ  . PHE B 1 126 ? -12.469 24.653  6.409   1.00 11.69 ? 151 PHE B CZ  1 
ATOM   3030 N N   . ALA B 1 127 ? -15.284 28.978  4.241   1.00 9.24  ? 152 ALA B N   1 
ATOM   3031 C CA  . ALA B 1 127 ? -14.343 29.454  3.235   1.00 8.54  ? 152 ALA B CA  1 
ATOM   3032 C C   . ALA B 1 127 ? -13.728 30.788  3.647   1.00 9.18  ? 152 ALA B C   1 
ATOM   3033 O O   . ALA B 1 127 ? -12.509 30.975  3.551   1.00 8.15  ? 152 ALA B O   1 
ATOM   3034 C CB  . ALA B 1 127 ? -15.045 29.565  1.879   1.00 9.72  ? 152 ALA B CB  1 
ATOM   3035 N N   . ARG B 1 128 ? -14.555 31.721  4.141   1.00 9.15  ? 153 ARG B N   1 
ATOM   3036 C CA  . ARG B 1 128 ? -14.014 33.002  4.589   1.00 8.67  ? 153 ARG B CA  1 
ATOM   3037 C C   . ARG B 1 128 ? -13.034 32.813  5.742   1.00 9.51  ? 153 ARG B C   1 
ATOM   3038 O O   . ARG B 1 128 ? -11.990 33.475  5.794   1.00 11.63 ? 153 ARG B O   1 
ATOM   3039 C CB  . ARG B 1 128 ? -15.144 33.945  5.004   1.00 8.08  ? 153 ARG B CB  1 
ATOM   3040 C CG  . ARG B 1 128 ? -16.100 34.312  3.883   1.00 10.07 ? 153 ARG B CG  1 
ATOM   3041 C CD  . ARG B 1 128 ? -15.419 35.132  2.767   1.00 7.86  ? 153 ARG B CD  1 
ATOM   3042 N NE  . ARG B 1 128 ? -16.399 35.439  1.737   1.00 9.61  ? 153 ARG B NE  1 
ATOM   3043 C CZ  . ARG B 1 128 ? -16.714 34.617  0.744   1.00 12.63 ? 153 ARG B CZ  1 
ATOM   3044 N NH1 . ARG B 1 128 ? -16.037 33.498  0.536   1.00 10.48 ? 153 ARG B NH1 1 
ATOM   3045 N NH2 . ARG B 1 128 ? -17.740 34.915  -0.045  1.00 10.99 ? 153 ARG B NH2 1 
ATOM   3046 N N   . ALA B 1 129 ? -13.342 31.894  6.666   1.00 9.78  ? 154 ALA B N   1 
ATOM   3047 C CA  . ALA B 1 129 ? -12.479 31.693  7.822   1.00 9.63  ? 154 ALA B CA  1 
ATOM   3048 C C   . ALA B 1 129 ? -11.107 31.148  7.452   1.00 10.45 ? 154 ALA B C   1 
ATOM   3049 O O   . ALA B 1 129 ? -10.169 31.294  8.243   1.00 16.70 ? 154 ALA B O   1 
ATOM   3050 C CB  . ALA B 1 129 ? -13.149 30.758  8.829   1.00 12.17 ? 154 ALA B CB  1 
ATOM   3051 N N   . ILE B 1 130 ? -10.950 30.534  6.281   1.00 10.17 ? 155 ILE B N   1 
ATOM   3052 C CA  . ILE B 1 130 ? -9.638  30.045  5.873   1.00 11.36 ? 155 ILE B CA  1 
ATOM   3053 C C   . ILE B 1 130 ? -9.050  30.896  4.752   1.00 12.04 ? 155 ILE B C   1 
ATOM   3054 O O   . ILE B 1 130 ? -8.107  30.463  4.062   1.00 16.02 ? 155 ILE B O   1 
ATOM   3055 C CB  . ILE B 1 130 ? -9.670  28.553  5.497   1.00 10.38 ? 155 ILE B CB  1 
ATOM   3056 C CG1 . ILE B 1 130 ? -10.605 28.288  4.318   1.00 11.94 ? 155 ILE B CG1 1 
ATOM   3057 C CG2 . ILE B 1 130 ? -10.093 27.713  6.707   1.00 13.79 ? 155 ILE B CG2 1 
ATOM   3058 C CD1 . ILE B 1 130 ? -10.410 26.892  3.683   1.00 15.45 ? 155 ILE B CD1 1 
ATOM   3059 N N   . GLY B 1 131 ? -9.565  32.113  4.578   1.00 11.68 ? 156 GLY B N   1 
ATOM   3060 C CA  . GLY B 1 131 ? -8.938  33.085  3.710   1.00 13.39 ? 156 GLY B CA  1 
ATOM   3061 C C   . GLY B 1 131 ? -9.452  33.126  2.294   1.00 13.83 ? 156 GLY B C   1 
ATOM   3062 O O   . GLY B 1 131 ? -8.834  33.786  1.449   1.00 14.58 ? 156 GLY B O   1 
ATOM   3063 N N   . ASP B 1 132 ? -10.550 32.439  2.004   1.00 10.79 ? 157 ASP B N   1 
ATOM   3064 C CA  . ASP B 1 132 ? -11.116 32.385  0.660   1.00 11.72 ? 157 ASP B CA  1 
ATOM   3065 C C   . ASP B 1 132 ? -12.263 33.381  0.613   1.00 9.30  ? 157 ASP B C   1 
ATOM   3066 O O   . ASP B 1 132 ? -13.327 33.138  1.188   1.00 11.05 ? 157 ASP B O   1 
ATOM   3067 C CB  . ASP B 1 132 ? -11.583 30.972  0.321   1.00 9.98  ? 157 ASP B CB  1 
ATOM   3068 C CG  . ASP B 1 132 ? -11.987 30.812  -1.134  1.00 12.37 ? 157 ASP B CG  1 
ATOM   3069 O OD1 . ASP B 1 132 ? -12.497 31.770  -1.752  1.00 11.97 ? 157 ASP B OD1 1 
ATOM   3070 O OD2 . ASP B 1 132 ? -11.799 29.699  -1.674  1.00 13.07 ? 157 ASP B OD2 1 
ATOM   3071 N N   . GLU B 1 133 ? -12.028 34.503  -0.056  1.00 10.95 ? 158 GLU B N   1 
ATOM   3072 C CA  . GLU B 1 133 ? -12.991 35.585  -0.174  1.00 10.97 ? 158 GLU B CA  1 
ATOM   3073 C C   . GLU B 1 133 ? -13.863 35.468  -1.417  1.00 9.77  ? 158 GLU B C   1 
ATOM   3074 O O   . GLU B 1 133 ? -14.699 36.346  -1.659  1.00 13.31 ? 158 GLU B O   1 
ATOM   3075 C CB  . GLU B 1 133 ? -12.246 36.927  -0.184  1.00 17.54 ? 158 GLU B CB  1 
ATOM   3076 C CG  . GLU B 1 133 ? -11.777 37.413  1.196   1.00 16.73 ? 158 GLU B CG  1 
ATOM   3077 C CD  . GLU B 1 133 ? -12.921 37.656  2.170   1.00 24.80 ? 158 GLU B CD  1 
ATOM   3078 O OE1 . GLU B 1 133 ? -13.968 38.180  1.733   1.00 28.51 ? 158 GLU B OE1 1 
ATOM   3079 O OE2 . GLU B 1 133 ? -12.764 37.366  3.376   1.00 27.67 ? 158 GLU B OE2 1 
ATOM   3080 N N   . THR B 1 134 ? -13.704 34.395  -2.193  1.00 8.91  ? 159 THR B N   1 
ATOM   3081 C CA  . THR B 1 134 ? -14.288 34.278  -3.520  1.00 9.54  ? 159 THR B CA  1 
ATOM   3082 C C   . THR B 1 134 ? -15.390 33.235  -3.587  1.00 9.08  ? 159 THR B C   1 
ATOM   3083 O O   . THR B 1 134 ? -16.457 33.475  -4.174  1.00 10.02 ? 159 THR B O   1 
ATOM   3084 C CB  . THR B 1 134 ? -13.181 33.931  -4.529  1.00 11.43 ? 159 THR B CB  1 
ATOM   3085 O OG1 . THR B 1 134 ? -12.116 34.894  -4.435  1.00 13.22 ? 159 THR B OG1 1 
ATOM   3086 C CG2 . THR B 1 134 ? -13.711 33.874  -5.970  1.00 11.65 ? 159 THR B CG2 1 
ATOM   3087 N N   . PHE B 1 135 ? -15.135 32.070  -2.992  1.00 9.15  ? 160 PHE B N   1 
ATOM   3088 C CA  . PHE B 1 135 ? -16.090 30.972  -2.946  1.00 7.87  ? 160 PHE B CA  1 
ATOM   3089 C C   . PHE B 1 135 ? -17.442 31.447  -2.437  1.00 9.56  ? 160 PHE B C   1 
ATOM   3090 O O   . PHE B 1 135 ? -17.529 32.179  -1.450  1.00 9.62  ? 160 PHE B O   1 
ATOM   3091 C CB  . PHE B 1 135 ? -15.518 29.886  -2.020  1.00 9.59  ? 160 PHE B CB  1 
ATOM   3092 C CG  . PHE B 1 135 ? -16.440 28.724  -1.747  1.00 6.73  ? 160 PHE B CG  1 
ATOM   3093 C CD1 . PHE B 1 135 ? -17.461 28.805  -0.805  1.00 7.44  ? 160 PHE B CD1 1 
ATOM   3094 C CD2 . PHE B 1 135 ? -16.246 27.531  -2.398  1.00 8.57  ? 160 PHE B CD2 1 
ATOM   3095 C CE1 . PHE B 1 135 ? -18.300 27.723  -0.547  1.00 8.81  ? 160 PHE B CE1 1 
ATOM   3096 C CE2 . PHE B 1 135 ? -17.054 26.437  -2.140  1.00 9.66  ? 160 PHE B CE2 1 
ATOM   3097 C CZ  . PHE B 1 135 ? -18.097 26.530  -1.217  1.00 8.06  ? 160 PHE B CZ  1 
ATOM   3098 N N   . ARG B 1 136 ? -18.508 30.998  -3.084  1.00 7.98  ? 161 ARG B N   1 
ATOM   3099 C CA  . ARG B 1 136 ? -19.823 31.167  -2.478  1.00 8.18  ? 161 ARG B CA  1 
ATOM   3100 C C   . ARG B 1 136 ? -20.664 29.935  -2.761  1.00 8.58  ? 161 ARG B C   1 
ATOM   3101 O O   . ARG B 1 136 ? -20.711 29.457  -3.903  1.00 9.52  ? 161 ARG B O   1 
ATOM   3102 C CB  . ARG B 1 136 ? -20.521 32.439  -2.981  1.00 9.30  ? 161 ARG B CB  1 
ATOM   3103 C CG  . ARG B 1 136 ? -20.567 32.570  -4.485  1.00 9.14  ? 161 ARG B CG  1 
ATOM   3104 C CD  . ARG B 1 136 ? -21.132 33.911  -4.905  1.00 10.92 ? 161 ARG B CD  1 
ATOM   3105 N NE  . ARG B 1 136 ? -22.569 33.977  -4.668  1.00 8.85  ? 161 ARG B NE  1 
ATOM   3106 C CZ  . ARG B 1 136 ? -23.296 35.063  -4.874  1.00 11.39 ? 161 ARG B CZ  1 
ATOM   3107 N NH1 . ARG B 1 136 ? -22.739 36.184  -5.302  1.00 10.93 ? 161 ARG B NH1 1 
ATOM   3108 N NH2 . ARG B 1 136 ? -24.605 35.024  -4.637  1.00 11.13 ? 161 ARG B NH2 1 
ATOM   3109 N N   . LEU B 1 137 ? -21.321 29.428  -1.719  1.00 8.22  ? 162 LEU B N   1 
ATOM   3110 C CA  . LEU B 1 137 ? -22.335 28.396  -1.865  1.00 7.50  ? 162 LEU B CA  1 
ATOM   3111 C C   . LEU B 1 137 ? -23.664 29.022  -1.469  1.00 7.94  ? 162 LEU B C   1 
ATOM   3112 O O   . LEU B 1 137 ? -23.793 29.580  -0.369  1.00 10.04 ? 162 LEU B O   1 
ATOM   3113 C CB  . LEU B 1 137 ? -22.023 27.163  -1.011  1.00 10.86 ? 162 LEU B CB  1 
ATOM   3114 C CG  . LEU B 1 137 ? -22.813 25.927  -1.454  1.00 9.62  ? 162 LEU B CG  1 
ATOM   3115 C CD1 . LEU B 1 137 ? -22.341 25.429  -2.808  1.00 10.99 ? 162 LEU B CD1 1 
ATOM   3116 C CD2 . LEU B 1 137 ? -22.732 24.812  -0.419  1.00 11.07 ? 162 LEU B CD2 1 
ATOM   3117 N N   . ASP B 1 138 ? -24.636 28.946  -2.375  1.00 7.46  ? 163 ASP B N   1 
ATOM   3118 C CA  . ASP B 1 138 ? -25.919 29.613  -2.216  1.00 8.31  ? 163 ASP B CA  1 
ATOM   3119 C C   . ASP B 1 138 ? -27.101 28.665  -2.145  1.00 10.41 ? 163 ASP B C   1 
ATOM   3120 O O   . ASP B 1 138 ? -28.143 29.041  -1.584  1.00 9.30  ? 163 ASP B O   1 
ATOM   3121 C CB  . ASP B 1 138 ? -26.149 30.597  -3.377  1.00 9.89  ? 163 ASP B CB  1 
ATOM   3122 C CG  . ASP B 1 138 ? -25.096 31.681  -3.422  1.00 11.58 ? 163 ASP B CG  1 
ATOM   3123 O OD1 . ASP B 1 138 ? -25.288 32.701  -2.737  1.00 13.98 ? 163 ASP B OD1 1 
ATOM   3124 O OD2 . ASP B 1 138 ? -24.060 31.503  -4.100  1.00 8.05  ? 163 ASP B OD2 1 
ATOM   3125 N N   . ARG B 1 139 ? -26.981 27.463  -2.690  1.00 9.32  ? 164 ARG B N   1 
ATOM   3126 C CA  . ARG B 1 139 ? -28.090 26.524  -2.755  1.00 9.48  ? 164 ARG B CA  1 
ATOM   3127 C C   . ARG B 1 139 ? -27.613 25.144  -2.332  1.00 9.48  ? 164 ARG B C   1 
ATOM   3128 O O   . ARG B 1 139 ? -26.417 24.885  -2.197  1.00 9.03  ? 164 ARG B O   1 
ATOM   3129 C CB  . ARG B 1 139 ? -28.697 26.477  -4.169  1.00 10.17 ? 164 ARG B CB  1 
ATOM   3130 C CG  . ARG B 1 139 ? -29.406 27.772  -4.548  1.00 9.47  ? 164 ARG B CG  1 
ATOM   3131 C CD  . ARG B 1 139 ? -29.732 27.846  -6.033  1.00 7.97  ? 164 ARG B CD  1 
ATOM   3132 N NE  . ARG B 1 139 ? -28.515 27.945  -6.821  1.00 9.32  ? 164 ARG B NE  1 
ATOM   3133 C CZ  . ARG B 1 139 ? -28.469 27.798  -8.137  1.00 9.49  ? 164 ARG B CZ  1 
ATOM   3134 N NH1 . ARG B 1 139 ? -29.576 27.649  -8.853  1.00 9.48  ? 164 ARG B NH1 1 
ATOM   3135 N NH2 . ARG B 1 139 ? -27.287 27.788  -8.742  1.00 8.94  ? 164 ARG B NH2 1 
ATOM   3136 N N   . THR B 1 140 ? -28.575 24.264  -2.109  1.00 8.56  ? 165 THR B N   1 
ATOM   3137 C CA  . THR B 1 140 ? -28.326 22.860  -1.835  1.00 7.13  ? 165 THR B CA  1 
ATOM   3138 C C   . THR B 1 140 ? -28.306 22.062  -3.139  1.00 9.83  ? 165 THR B C   1 
ATOM   3139 O O   . THR B 1 140 ? -28.496 22.599  -4.235  1.00 9.96  ? 165 THR B O   1 
ATOM   3140 C CB  . THR B 1 140 ? -29.411 22.301  -0.913  1.00 7.80  ? 165 THR B CB  1 
ATOM   3141 O OG1 . THR B 1 140 ? -30.690 22.476  -1.545  1.00 11.27 ? 165 THR B OG1 1 
ATOM   3142 C CG2 . THR B 1 140 ? -29.414 23.034  0.399   1.00 12.36 ? 165 THR B CG2 1 
ATOM   3143 N N   . GLU B 1 141 ? -28.063 20.739  -3.024  1.00 8.98  ? 166 GLU B N   1 
ATOM   3144 C CA  . GLU B 1 141 ? -28.268 19.827  -4.144  1.00 7.91  ? 166 GLU B CA  1 
ATOM   3145 C C   . GLU B 1 141 ? -29.759 19.572  -4.352  1.00 9.73  ? 166 GLU B C   1 
ATOM   3146 O O   . GLU B 1 141 ? -30.497 19.403  -3.379  1.00 10.98 ? 166 GLU B O   1 
ATOM   3147 C CB  . GLU B 1 141 ? -27.578 18.490  -3.881  1.00 9.57  ? 166 GLU B CB  1 
ATOM   3148 C CG  . GLU B 1 141 ? -26.076 18.549  -3.735  1.00 11.03 ? 166 GLU B CG  1 
ATOM   3149 C CD  . GLU B 1 141 ? -25.376 18.725  -5.055  1.00 12.77 ? 166 GLU B CD  1 
ATOM   3150 O OE1 . GLU B 1 141 ? -26.071 18.778  -6.088  1.00 13.27 ? 166 GLU B OE1 1 
ATOM   3151 O OE2 . GLU B 1 141 ? -24.123 18.787  -5.075  1.00 15.50 ? 166 GLU B OE2 1 
ATOM   3152 N N   . PRO B 1 142 ? -30.226 19.486  -5.604  1.00 9.89  ? 167 PRO B N   1 
ATOM   3153 C CA  . PRO B 1 142 ? -29.460 19.497  -6.845  1.00 10.47 ? 167 PRO B CA  1 
ATOM   3154 C C   . PRO B 1 142 ? -29.384 20.845  -7.530  1.00 10.90 ? 167 PRO B C   1 
ATOM   3155 O O   . PRO B 1 142 ? -28.682 20.969  -8.544  1.00 11.79 ? 167 PRO B O   1 
ATOM   3156 C CB  . PRO B 1 142 ? -30.229 18.485  -7.703  1.00 10.22 ? 167 PRO B CB  1 
ATOM   3157 C CG  . PRO B 1 142 ? -31.645 18.741  -7.332  1.00 12.53 ? 167 PRO B CG  1 
ATOM   3158 C CD  . PRO B 1 142 ? -31.617 19.071  -5.843  1.00 12.34 ? 167 PRO B CD  1 
ATOM   3159 N N   . THR B 1 143 ? -30.038 21.886  -7.007  1.00 8.65  ? 168 THR B N   1 
ATOM   3160 C CA  . THR B 1 143 ? -30.119 23.120  -7.783  1.00 9.14  ? 168 THR B CA  1 
ATOM   3161 C C   . THR B 1 143 ? -28.800 23.883  -7.837  1.00 10.59 ? 168 THR B C   1 
ATOM   3162 O O   . THR B 1 143 ? -28.631 24.723  -8.721  1.00 10.23 ? 168 THR B O   1 
ATOM   3163 C CB  . THR B 1 143 ? -31.241 24.040  -7.267  1.00 9.35  ? 168 THR B CB  1 
ATOM   3164 O OG1 . THR B 1 143 ? -30.997 24.461  -5.914  1.00 10.54 ? 168 THR B OG1 1 
ATOM   3165 C CG2 . THR B 1 143 ? -32.603 23.358  -7.359  1.00 10.86 ? 168 THR B CG2 1 
ATOM   3166 N N   . LEU B 1 144 ? -27.841 23.593  -6.959  1.00 7.96  ? 169 LEU B N   1 
ATOM   3167 C CA  . LEU B 1 144 ? -26.542 24.247  -7.107  1.00 9.17  ? 169 LEU B CA  1 
ATOM   3168 C C   . LEU B 1 144 ? -25.826 23.868  -8.404  1.00 8.41  ? 169 LEU B C   1 
ATOM   3169 O O   . LEU B 1 144 ? -24.778 24.459  -8.700  1.00 12.06 ? 169 LEU B O   1 
ATOM   3170 C CB  . LEU B 1 144 ? -25.641 23.952  -5.897  1.00 9.67  ? 169 LEU B CB  1 
ATOM   3171 C CG  . LEU B 1 144 ? -25.234 22.508  -5.587  1.00 10.32 ? 169 LEU B CG  1 
ATOM   3172 C CD1 . LEU B 1 144 ? -24.057 22.075  -6.434  1.00 12.91 ? 169 LEU B CD1 1 
ATOM   3173 C CD2 . LEU B 1 144 ? -24.804 22.423  -4.127  1.00 13.13 ? 169 LEU B CD2 1 
ATOM   3174 N N   . ASN B 1 145 ? -26.358 22.920  -9.190  1.00 8.64  ? 170 ASN B N   1 
ATOM   3175 C CA  . ASN B 1 145 ? -25.757 22.498  -10.453 1.00 6.99  ? 170 ASN B CA  1 
ATOM   3176 C C   . ASN B 1 145 ? -26.368 23.151  -11.691 1.00 11.78 ? 170 ASN B C   1 
ATOM   3177 O O   . ASN B 1 145 ? -26.041 22.734  -12.809 1.00 9.77  ? 170 ASN B O   1 
ATOM   3178 C CB  . ASN B 1 145 ? -25.862 20.980  -10.600 1.00 9.22  ? 170 ASN B CB  1 
ATOM   3179 C CG  . ASN B 1 145 ? -25.187 20.264  -9.474  1.00 14.94 ? 170 ASN B CG  1 
ATOM   3180 O OD1 . ASN B 1 145 ? -23.966 20.338  -9.334  1.00 13.17 ? 170 ASN B OD1 1 
ATOM   3181 N ND2 . ASN B 1 145 ? -25.972 19.593  -8.635  1.00 15.62 ? 170 ASN B ND2 1 
ATOM   3182 N N   . THR B 1 146 ? -27.242 24.152  -11.536 1.00 8.72  ? 171 THR B N   1 
ATOM   3183 C CA  . THR B 1 146 ? -27.881 24.733  -12.715 1.00 8.10  ? 171 THR B CA  1 
ATOM   3184 C C   . THR B 1 146 ? -26.874 25.389  -13.651 1.00 9.55  ? 171 THR B C   1 
ATOM   3185 O O   . THR B 1 146 ? -27.111 25.437  -14.865 1.00 10.62 ? 171 THR B O   1 
ATOM   3186 C CB  . THR B 1 146 ? -28.959 25.743  -12.323 1.00 8.69  ? 171 THR B CB  1 
ATOM   3187 O OG1 . THR B 1 146 ? -28.441 26.708  -11.392 1.00 9.37  ? 171 THR B OG1 1 
ATOM   3188 C CG2 . THR B 1 146 ? -30.128 25.023  -11.694 1.00 10.37 ? 171 THR B CG2 1 
ATOM   3189 N N   . ALA B 1 147 ? -25.777 25.939  -13.108 1.00 8.86  ? 172 ALA B N   1 
ATOM   3190 C CA  . ALA B 1 147 ? -24.615 26.350  -13.900 1.00 8.16  ? 172 ALA B CA  1 
ATOM   3191 C C   . ALA B 1 147 ? -24.966 27.344  -15.006 1.00 8.70  ? 172 ALA B C   1 
ATOM   3192 O O   . ALA B 1 147 ? -24.378 27.321  -16.089 1.00 10.43 ? 172 ALA B O   1 
ATOM   3193 C CB  . ALA B 1 147 ? -23.912 25.120  -14.481 1.00 9.21  ? 172 ALA B CB  1 
ATOM   3194 N N   . ILE B 1 148 ? -25.909 28.234  -14.730 1.00 9.33  ? 173 ILE B N   1 
ATOM   3195 C CA  . ILE B 1 148 ? -26.395 29.175  -15.752 1.00 11.17 ? 173 ILE B CA  1 
ATOM   3196 C C   . ILE B 1 148 ? -25.300 30.193  -16.052 1.00 9.67  ? 173 ILE B C   1 
ATOM   3197 O O   . ILE B 1 148 ? -24.713 30.758  -15.112 1.00 10.40 ? 173 ILE B O   1 
ATOM   3198 C CB  . ILE B 1 148 ? -27.669 29.872  -15.266 1.00 11.35 ? 173 ILE B CB  1 
ATOM   3199 C CG1 . ILE B 1 148 ? -28.788 28.852  -15.010 1.00 11.35 ? 173 ILE B CG1 1 
ATOM   3200 C CG2 . ILE B 1 148 ? -28.082 30.976  -16.256 1.00 12.42 ? 173 ILE B CG2 1 
ATOM   3201 C CD1 . ILE B 1 148 ? -29.945 29.368  -14.168 1.00 14.64 ? 173 ILE B CD1 1 
ATOM   3202 N N   . PRO B 1 149 ? -24.986 30.484  -17.313 1.00 9.88  ? 174 PRO B N   1 
ATOM   3203 C CA  . PRO B 1 149 ? -23.917 31.459  -17.574 1.00 9.09  ? 174 PRO B CA  1 
ATOM   3204 C C   . PRO B 1 149 ? -24.278 32.813  -16.982 1.00 9.33  ? 174 PRO B C   1 
ATOM   3205 O O   . PRO B 1 149 ? -25.431 33.242  -17.043 1.00 11.03 ? 174 PRO B O   1 
ATOM   3206 C CB  . PRO B 1 149 ? -23.840 31.507  -19.104 1.00 10.08 ? 174 PRO B CB  1 
ATOM   3207 C CG  . PRO B 1 149 ? -24.354 30.149  -19.537 1.00 14.47 ? 174 PRO B CG  1 
ATOM   3208 C CD  . PRO B 1 149 ? -25.462 29.835  -18.547 1.00 13.03 ? 174 PRO B CD  1 
ATOM   3209 N N   . GLY B 1 150 ? -23.285 33.464  -16.379 1.00 11.36 ? 175 GLY B N   1 
ATOM   3210 C CA  . GLY B 1 150 ? -23.476 34.767  -15.761 1.00 10.39 ? 175 GLY B CA  1 
ATOM   3211 C C   . GLY B 1 150 ? -24.040 34.738  -14.361 1.00 13.26 ? 175 GLY B C   1 
ATOM   3212 O O   . GLY B 1 150 ? -24.100 35.791  -13.712 1.00 12.36 ? 175 GLY B O   1 
ATOM   3213 N N   . ASP B 1 151 ? -24.460 33.576  -13.876 1.00 11.22 ? 176 ASP B N   1 
ATOM   3214 C CA  . ASP B 1 151 ? -25.081 33.450  -12.567 1.00 9.64  ? 176 ASP B CA  1 
ATOM   3215 C C   . ASP B 1 151 ? -23.985 33.307  -11.521 1.00 11.88 ? 176 ASP B C   1 
ATOM   3216 O O   . ASP B 1 151 ? -23.167 32.389  -11.623 1.00 11.16 ? 176 ASP B O   1 
ATOM   3217 C CB  . ASP B 1 151 ? -26.002 32.239  -12.559 1.00 10.59 ? 176 ASP B CB  1 
ATOM   3218 C CG  . ASP B 1 151 ? -26.817 32.100  -11.294 1.00 10.83 ? 176 ASP B CG  1 
ATOM   3219 O OD1 . ASP B 1 151 ? -26.594 32.828  -10.300 1.00 10.99 ? 176 ASP B OD1 1 
ATOM   3220 O OD2 . ASP B 1 151 ? -27.710 31.234  -11.317 1.00 17.53 ? 176 ASP B OD2 1 
ATOM   3221 N N   . PRO B 1 152 ? -23.913 34.189  -10.521 1.00 9.50  ? 177 PRO B N   1 
ATOM   3222 C CA  . PRO B 1 152 ? -22.833 34.089  -9.530  1.00 11.32 ? 177 PRO B CA  1 
ATOM   3223 C C   . PRO B 1 152 ? -23.066 33.026  -8.471  1.00 8.47  ? 177 PRO B C   1 
ATOM   3224 O O   . PRO B 1 152 ? -22.124 32.699  -7.735  1.00 9.50  ? 177 PRO B O   1 
ATOM   3225 C CB  . PRO B 1 152 ? -22.820 35.481  -8.890  1.00 13.13 ? 177 PRO B CB  1 
ATOM   3226 C CG  . PRO B 1 152 ? -24.191 35.989  -9.053  1.00 16.18 ? 177 PRO B CG  1 
ATOM   3227 C CD  . PRO B 1 152 ? -24.790 35.348  -10.283 1.00 12.17 ? 177 PRO B CD  1 
ATOM   3228 N N   . ARG B 1 153 ? -24.279 32.491  -8.364  1.00 7.49  ? 178 ARG B N   1 
ATOM   3229 C CA  . ARG B 1 153 ? -24.561 31.525  -7.314  1.00 6.28  ? 178 ARG B CA  1 
ATOM   3230 C C   . ARG B 1 153 ? -23.714 30.272  -7.489  1.00 7.47  ? 178 ARG B C   1 
ATOM   3231 O O   . ARG B 1 153 ? -23.549 29.754  -8.595  1.00 8.82  ? 178 ARG B O   1 
ATOM   3232 C CB  . ARG B 1 153 ? -26.039 31.168  -7.325  1.00 8.64  ? 178 ARG B CB  1 
ATOM   3233 C CG  . ARG B 1 153 ? -26.951 32.351  -6.969  1.00 7.96  ? 178 ARG B CG  1 
ATOM   3234 C CD  . ARG B 1 153 ? -28.410 31.925  -7.044  1.00 9.72  ? 178 ARG B CD  1 
ATOM   3235 N NE  . ARG B 1 153 ? -28.755 31.620  -8.431  1.00 8.20  ? 178 ARG B NE  1 
ATOM   3236 C CZ  . ARG B 1 153 ? -29.909 31.110  -8.835  1.00 8.90  ? 178 ARG B CZ  1 
ATOM   3237 N NH1 . ARG B 1 153 ? -30.913 30.905  -7.992  1.00 11.77 ? 178 ARG B NH1 1 
ATOM   3238 N NH2 . ARG B 1 153 ? -30.048 30.753  -10.109 1.00 11.36 ? 178 ARG B NH2 1 
ATOM   3239 N N   . ASP B 1 154 ? -23.165 29.796  -6.379  1.00 6.10  ? 179 ASP B N   1 
ATOM   3240 C CA  . ASP B 1 154 ? -22.481 28.508  -6.346  1.00 7.14  ? 179 ASP B CA  1 
ATOM   3241 C C   . ASP B 1 154 ? -21.291 28.502  -7.299  1.00 6.79  ? 179 ASP B C   1 
ATOM   3242 O O   . ASP B 1 154 ? -21.039 27.523  -8.014  1.00 8.85  ? 179 ASP B O   1 
ATOM   3243 C CB  . ASP B 1 154 ? -23.461 27.380  -6.650  1.00 9.06  ? 179 ASP B CB  1 
ATOM   3244 C CG  . ASP B 1 154 ? -24.689 27.464  -5.764  1.00 7.00  ? 179 ASP B CG  1 
ATOM   3245 O OD1 . ASP B 1 154 ? -24.512 27.351  -4.527  1.00 9.55  ? 179 ASP B OD1 1 
ATOM   3246 O OD2 . ASP B 1 154 ? -25.796 27.698  -6.286  1.00 10.28 ? 179 ASP B OD2 1 
ATOM   3247 N N   . THR B 1 155 ? -20.530 29.589  -7.277  1.00 7.67  ? 180 THR B N   1 
ATOM   3248 C CA  . THR B 1 155 ? -19.358 29.747  -8.126  1.00 7.24  ? 180 THR B CA  1 
ATOM   3249 C C   . THR B 1 155 ? -18.110 30.030  -7.305  1.00 9.75  ? 180 THR B C   1 
ATOM   3250 O O   . THR B 1 155 ? -18.169 30.446  -6.143  1.00 8.82  ? 180 THR B O   1 
ATOM   3251 C CB  . THR B 1 155 ? -19.507 30.892  -9.148  1.00 7.70  ? 180 THR B CB  1 
ATOM   3252 O OG1 . THR B 1 155 ? -19.674 32.141  -8.455  1.00 9.91  ? 180 THR B OG1 1 
ATOM   3253 C CG2 . THR B 1 155 ? -20.679 30.677  -10.077 1.00 10.52 ? 180 THR B CG2 1 
ATOM   3254 N N   . THR B 1 156 ? -16.967 29.836  -7.958  1.00 7.49  ? 181 THR B N   1 
ATOM   3255 C CA  . THR B 1 156 ? -15.695 30.389  -7.497  1.00 8.82  ? 181 THR B CA  1 
ATOM   3256 C C   . THR B 1 156 ? -14.813 30.652  -8.715  1.00 9.66  ? 181 THR B C   1 
ATOM   3257 O O   . THR B 1 156 ? -15.238 30.467  -9.855  1.00 9.69  ? 181 THR B O   1 
ATOM   3258 C CB  . THR B 1 156 ? -15.030 29.463  -6.468  1.00 10.03 ? 181 THR B CB  1 
ATOM   3259 O OG1 . THR B 1 156 ? -13.982 30.183  -5.799  1.00 10.26 ? 181 THR B OG1 1 
ATOM   3260 C CG2 . THR B 1 156 ? -14.488 28.205  -7.123  1.00 8.39  ? 181 THR B CG2 1 
ATOM   3261 N N   . THR B 1 157 ? -13.577 31.086  -8.476  1.00 7.64  ? 182 THR B N   1 
ATOM   3262 C CA  . THR B 1 157 ? -12.592 31.253  -9.540  1.00 8.99  ? 182 THR B CA  1 
ATOM   3263 C C   . THR B 1 157 ? -11.518 30.175  -9.451  1.00 9.25  ? 182 THR B C   1 
ATOM   3264 O O   . THR B 1 157 ? -11.284 29.601  -8.382  1.00 8.15  ? 182 THR B O   1 
ATOM   3265 C CB  . THR B 1 157 ? -11.902 32.625  -9.495  1.00 10.51 ? 182 THR B CB  1 
ATOM   3266 O OG1 . THR B 1 157 ? -11.070 32.716  -8.324  1.00 9.59  ? 182 THR B OG1 1 
ATOM   3267 C CG2 . THR B 1 157 ? -12.916 33.763  -9.521  1.00 10.87 ? 182 THR B CG2 1 
ATOM   3268 N N   . PRO B 1 158 ? -10.843 29.859  -10.558 1.00 8.57  ? 183 PRO B N   1 
ATOM   3269 C CA  . PRO B 1 158 ? -9.768  28.851  -10.465 1.00 9.45  ? 183 PRO B CA  1 
ATOM   3270 C C   . PRO B 1 158 ? -8.678  29.245  -9.485  1.00 8.85  ? 183 PRO B C   1 
ATOM   3271 O O   . PRO B 1 158 ? -8.244  28.399  -8.684  1.00 9.81  ? 183 PRO B O   1 
ATOM   3272 C CB  . PRO B 1 158 ? -9.264  28.752  -11.914 1.00 10.23 ? 183 PRO B CB  1 
ATOM   3273 C CG  . PRO B 1 158 ? -10.473 29.112  -12.739 1.00 8.26  ? 183 PRO B CG  1 
ATOM   3274 C CD  . PRO B 1 158 ? -11.133 30.231  -11.956 1.00 9.46  ? 183 PRO B CD  1 
ATOM   3275 N N   . ARG B 1 159 ? -8.281  30.525  -9.479  1.00 8.55  ? 184 ARG B N   1 
ATOM   3276 C CA  . ARG B 1 159 ? -7.235  30.984  -8.571  1.00 10.17 ? 184 ARG B CA  1 
ATOM   3277 C C   . ARG B 1 159 ? -7.642  30.758  -7.129  1.00 11.21 ? 184 ARG B C   1 
ATOM   3278 O O   . ARG B 1 159 ? -6.866  30.229  -6.333  1.00 9.04  ? 184 ARG B O   1 
ATOM   3279 C CB  . ARG B 1 159 ? -6.930  32.462  -8.829  1.00 10.47 ? 184 ARG B CB  1 
ATOM   3280 C CG  . ARG B 1 159 ? -5.644  32.945  -8.135  1.00 13.46 ? 184 ARG B CG  1 
ATOM   3281 C CD  . ARG B 1 159 ? -5.712  34.439  -7.808  1.00 16.23 ? 184 ARG B CD  1 
ATOM   3282 N NE  . ARG B 1 159 ? -5.639  35.268  -9.005  1.00 18.42 ? 184 ARG B NE  1 
ATOM   3283 C CZ  . ARG B 1 159 ? -4.505  35.711  -9.537  1.00 33.37 ? 184 ARG B CZ  1 
ATOM   3284 N NH1 . ARG B 1 159 ? -3.327  35.374  -9.035  1.00 31.05 ? 184 ARG B NH1 1 
ATOM   3285 N NH2 . ARG B 1 159 ? -4.553  36.500  -10.608 1.00 32.39 ? 184 ARG B NH2 1 
ATOM   3286 N N   . ALA B 1 160 ? -8.871  31.141  -6.775  1.00 8.99  ? 185 ALA B N   1 
ATOM   3287 C CA  . ALA B 1 160 ? -9.279  30.994  -5.386  1.00 8.97  ? 185 ALA B CA  1 
ATOM   3288 C C   . ALA B 1 160 ? -9.358  29.532  -4.978  1.00 10.37 ? 185 ALA B C   1 
ATOM   3289 O O   . ALA B 1 160 ? -8.943  29.178  -3.869  1.00 9.99  ? 185 ALA B O   1 
ATOM   3290 C CB  . ALA B 1 160 ? -10.615 31.687  -5.149  1.00 11.15 ? 185 ALA B CB  1 
ATOM   3291 N N   A MET B 1 161 ? -9.885  28.663  -5.847  0.62 7.73  ? 186 MET B N   1 
ATOM   3292 N N   B MET B 1 161 ? -9.888  28.667  -5.848  0.38 7.77  ? 186 MET B N   1 
ATOM   3293 C CA  A MET B 1 161 ? -10.054 27.280  -5.426  0.62 8.52  ? 186 MET B CA  1 
ATOM   3294 C CA  B MET B 1 161 ? -10.056 27.274  -5.456  0.38 8.53  ? 186 MET B CA  1 
ATOM   3295 C C   A MET B 1 161 ? -8.719  26.553  -5.354  0.62 8.19  ? 186 MET B C   1 
ATOM   3296 C C   B MET B 1 161 ? -8.715  26.565  -5.346  0.38 8.21  ? 186 MET B C   1 
ATOM   3297 O O   A MET B 1 161 ? -8.549  25.675  -4.504  0.62 9.28  ? 186 MET B O   1 
ATOM   3298 O O   B MET B 1 161 ? -8.534  25.710  -4.473  0.38 9.24  ? 186 MET B O   1 
ATOM   3299 C CB  A MET B 1 161 ? -11.027 26.540  -6.342  0.62 9.80  ? 186 MET B CB  1 
ATOM   3300 C CB  B MET B 1 161 ? -10.971 26.538  -6.433  0.38 9.74  ? 186 MET B CB  1 
ATOM   3301 C CG  A MET B 1 161 ? -11.325 25.143  -5.819  0.62 9.79  ? 186 MET B CG  1 
ATOM   3302 C CG  B MET B 1 161 ? -11.413 25.189  -5.885  0.38 9.85  ? 186 MET B CG  1 
ATOM   3303 S SD  A MET B 1 161 ? -12.332 25.192  -4.312  0.62 11.40 ? 186 MET B SD  1 
ATOM   3304 S SD  B MET B 1 161 ? -12.438 25.371  -4.406  0.38 10.70 ? 186 MET B SD  1 
ATOM   3305 C CE  A MET B 1 161 ? -13.969 24.872  -4.965  0.62 12.65 ? 186 MET B CE  1 
ATOM   3306 C CE  B MET B 1 161 ? -11.365 24.680  -3.148  0.38 14.07 ? 186 MET B CE  1 
ATOM   3307 N N   . ALA B 1 162 ? -7.759  26.902  -6.217  1.00 8.91  ? 187 ALA B N   1 
ATOM   3308 C CA  . ALA B 1 162 ? -6.438  26.290  -6.114  1.00 6.50  ? 187 ALA B CA  1 
ATOM   3309 C C   . ALA B 1 162 ? -5.749  26.680  -4.811  1.00 8.35  ? 187 ALA B C   1 
ATOM   3310 O O   . ALA B 1 162 ? -5.194  25.822  -4.112  1.00 8.12  ? 187 ALA B O   1 
ATOM   3311 C CB  . ALA B 1 162 ? -5.577  26.679  -7.317  1.00 8.48  ? 187 ALA B CB  1 
ATOM   3312 N N   . GLN B 1 163 ? -5.828  27.964  -4.435  1.00 8.72  ? 188 GLN B N   1 
ATOM   3313 C CA  . GLN B 1 163 ? -5.227  28.406  -3.184  1.00 8.95  ? 188 GLN B CA  1 
ATOM   3314 C C   . GLN B 1 163 ? -5.876  27.717  -1.989  1.00 9.03  ? 188 GLN B C   1 
ATOM   3315 O O   . GLN B 1 163 ? -5.185  27.221  -1.091  1.00 9.93  ? 188 GLN B O   1 
ATOM   3316 C CB  . GLN B 1 163 ? -5.331  29.927  -3.079  1.00 9.01  ? 188 GLN B CB  1 
ATOM   3317 C CG  . GLN B 1 163 ? -4.809  30.504  -1.774  1.00 17.65 ? 188 GLN B CG  1 
ATOM   3318 C CD  . GLN B 1 163 ? -3.320  30.317  -1.579  1.00 28.50 ? 188 GLN B CD  1 
ATOM   3319 O OE1 . GLN B 1 163 ? -2.560  30.204  -2.543  1.00 22.81 ? 188 GLN B OE1 1 
ATOM   3320 N NE2 . GLN B 1 163 ? -2.888  30.317  -0.317  1.00 25.87 ? 188 GLN B NE2 1 
ATOM   3321 N N   . THR B 1 164 ? -7.206  27.645  -1.977  1.00 9.13  ? 189 THR B N   1 
ATOM   3322 C CA  . THR B 1 164 ? -7.894  26.981  -0.877  1.00 8.49  ? 189 THR B CA  1 
ATOM   3323 C C   . THR B 1 164 ? -7.560  25.500  -0.821  1.00 7.39  ? 189 THR B C   1 
ATOM   3324 O O   . THR B 1 164 ? -7.292  24.956  0.257   1.00 9.07  ? 189 THR B O   1 
ATOM   3325 C CB  . THR B 1 164 ? -9.394  27.178  -1.027  1.00 10.86 ? 189 THR B CB  1 
ATOM   3326 O OG1 . THR B 1 164 ? -9.688  28.561  -0.817  1.00 13.66 ? 189 THR B OG1 1 
ATOM   3327 C CG2 . THR B 1 164 ? -10.137 26.349  0.007   1.00 23.95 ? 189 THR B CG2 1 
ATOM   3328 N N   . LEU B 1 165 ? -7.545  24.824  -1.972  1.00 8.81  ? 190 LEU B N   1 
ATOM   3329 C CA  . LEU B 1 165 ? -7.224  23.400  -1.940  1.00 8.18  ? 190 LEU B CA  1 
ATOM   3330 C C   . LEU B 1 165 ? -5.815  23.170  -1.411  1.00 8.77  ? 190 LEU B C   1 
ATOM   3331 O O   . LEU B 1 165 ? -5.581  22.213  -0.665  1.00 9.59  ? 190 LEU B O   1 
ATOM   3332 C CB  . LEU B 1 165 ? -7.387  22.774  -3.324  1.00 9.21  ? 190 LEU B CB  1 
ATOM   3333 C CG  . LEU B 1 165 ? -7.330  21.248  -3.403  1.00 8.62  ? 190 LEU B CG  1 
ATOM   3334 C CD1 . LEU B 1 165 ? -8.446  20.638  -2.570  1.00 11.53 ? 190 LEU B CD1 1 
ATOM   3335 C CD2 . LEU B 1 165 ? -7.462  20.820  -4.865  1.00 9.54  ? 190 LEU B CD2 1 
ATOM   3336 N N   . ARG B 1 166 ? -4.865  24.035  -1.779  1.00 10.22 ? 191 ARG B N   1 
ATOM   3337 C CA  . ARG B 1 166 ? -3.521  23.913  -1.220  1.00 7.06  ? 191 ARG B CA  1 
ATOM   3338 C C   . ARG B 1 166 ? -3.555  24.066  0.297   1.00 10.02 ? 191 ARG B C   1 
ATOM   3339 O O   . ARG B 1 166 ? -2.995  23.242  1.029   1.00 11.36 ? 191 ARG B O   1 
ATOM   3340 C CB  . ARG B 1 166 ? -2.571  24.935  -1.858  1.00 9.74  ? 191 ARG B CB  1 
ATOM   3341 C CG  . ARG B 1 166 ? -1.141  24.801  -1.329  1.00 10.10 ? 191 ARG B CG  1 
ATOM   3342 C CD  . ARG B 1 166 ? -0.284  26.017  -1.562  1.00 15.76 ? 191 ARG B CD  1 
ATOM   3343 N NE  . ARG B 1 166 ? 1.073   25.741  -1.093  1.00 16.14 ? 191 ARG B NE  1 
ATOM   3344 C CZ  . ARG B 1 166 ? 2.144   26.440  -1.438  1.00 13.50 ? 191 ARG B CZ  1 
ATOM   3345 N NH1 . ARG B 1 166 ? 2.052   27.502  -2.222  1.00 19.68 ? 191 ARG B NH1 1 
ATOM   3346 N NH2 . ARG B 1 166 ? 3.342   26.055  -0.994  1.00 14.52 ? 191 ARG B NH2 1 
ATOM   3347 N N   . GLN B 1 167 ? -4.254  25.086  0.793   1.00 8.99  ? 192 GLN B N   1 
ATOM   3348 C CA  . GLN B 1 167 ? -4.288  25.314  2.236   1.00 10.00 ? 192 GLN B CA  1 
ATOM   3349 C C   . GLN B 1 167 ? -4.951  24.157  2.981   1.00 11.46 ? 192 GLN B C   1 
ATOM   3350 O O   . GLN B 1 167 ? -4.535  23.805  4.090   1.00 10.60 ? 192 GLN B O   1 
ATOM   3351 C CB  . GLN B 1 167 ? -5.025  26.615  2.534   1.00 11.92 ? 192 GLN B CB  1 
ATOM   3352 C CG  . GLN B 1 167 ? -4.322  27.895  2.081   1.00 11.78 ? 192 GLN B CG  1 
ATOM   3353 C CD  . GLN B 1 167 ? -2.989  28.147  2.773   1.00 23.40 ? 192 GLN B CD  1 
ATOM   3354 O OE1 . GLN B 1 167 ? -2.079  27.317  2.745   1.00 29.13 ? 192 GLN B OE1 1 
ATOM   3355 N NE2 . GLN B 1 167 ? -2.873  29.309  3.403   1.00 19.18 ? 192 GLN B NE2 1 
ATOM   3356 N N   . LEU B 1 168 ? -5.975  23.552  2.385   1.00 8.01  ? 193 LEU B N   1 
ATOM   3357 C CA  . LEU B 1 168 ? -6.676  22.437  3.027   1.00 10.94 ? 193 LEU B CA  1 
ATOM   3358 C C   . LEU B 1 168 ? -5.838  21.164  3.039   1.00 10.33 ? 193 LEU B C   1 
ATOM   3359 O O   . LEU B 1 168 ? -5.855  20.414  4.024   1.00 11.49 ? 193 LEU B O   1 
ATOM   3360 C CB  . LEU B 1 168 ? -7.992  22.171  2.303   1.00 8.83  ? 193 LEU B CB  1 
ATOM   3361 C CG  . LEU B 1 168 ? -9.078  23.224  2.515   1.00 10.28 ? 193 LEU B CG  1 
ATOM   3362 C CD1 . LEU B 1 168 ? -10.280 22.921  1.634   1.00 11.53 ? 193 LEU B CD1 1 
ATOM   3363 C CD2 . LEU B 1 168 ? -9.493  23.262  3.993   1.00 9.46  ? 193 LEU B CD2 1 
ATOM   3364 N N   . THR B 1 169 ? -5.156  20.860  1.938   1.00 8.54  ? 194 THR B N   1 
ATOM   3365 C CA  . THR B 1 169 ? -4.540  19.538  1.785   1.00 9.59  ? 194 THR B CA  1 
ATOM   3366 C C   . THR B 1 169 ? -3.050  19.502  2.070   1.00 11.43 ? 194 THR B C   1 
ATOM   3367 O O   . THR B 1 169 ? -2.533  18.434  2.412   1.00 12.78 ? 194 THR B O   1 
ATOM   3368 C CB  . THR B 1 169 ? -4.751  18.992  0.372   1.00 9.90  ? 194 THR B CB  1 
ATOM   3369 O OG1 . THR B 1 169 ? -4.124  19.868  -0.578  1.00 10.93 ? 194 THR B OG1 1 
ATOM   3370 C CG2 . THR B 1 169 ? -6.235  18.838  0.062   1.00 9.69  ? 194 THR B CG2 1 
ATOM   3371 N N   . LEU B 1 170 ? -2.341  20.620  1.889   1.00 11.18 ? 195 LEU B N   1 
ATOM   3372 C CA  . LEU B 1 170 ? -0.905  20.685  2.101   1.00 11.14 ? 195 LEU B CA  1 
ATOM   3373 C C   . LEU B 1 170 ? -0.518  21.684  3.169   1.00 14.79 ? 195 LEU B C   1 
ATOM   3374 O O   . LEU B 1 170 ? 0.543   21.528  3.780   1.00 17.48 ? 195 LEU B O   1 
ATOM   3375 C CB  . LEU B 1 170 ? -0.185  21.036  0.784   1.00 10.70 ? 195 LEU B CB  1 
ATOM   3376 C CG  . LEU B 1 170 ? -0.477  20.101  -0.393  1.00 10.04 ? 195 LEU B CG  1 
ATOM   3377 C CD1 . LEU B 1 170 ? 0.076   20.683  -1.676  1.00 12.79 ? 195 LEU B CD1 1 
ATOM   3378 C CD2 . LEU B 1 170 ? 0.085   18.700  -0.137  1.00 15.46 ? 195 LEU B CD2 1 
ATOM   3379 N N   . GLY B 1 171 ? -1.348  22.682  3.424   1.00 11.06 ? 196 GLY B N   1 
ATOM   3380 C CA  . GLY B 1 171 ? -1.113  23.691  4.438   1.00 12.31 ? 196 GLY B CA  1 
ATOM   3381 C C   . GLY B 1 171 ? -1.794  23.372  5.752   1.00 15.84 ? 196 GLY B C   1 
ATOM   3382 O O   . GLY B 1 171 ? -2.033  22.207  6.097   1.00 14.53 ? 196 GLY B O   1 
ATOM   3383 N N   . HIS B 1 172 ? -2.125  24.420  6.495   1.00 10.75 ? 197 HIS B N   1 
ATOM   3384 C CA  . HIS B 1 172 ? -2.523  24.270  7.891   1.00 11.07 ? 197 HIS B CA  1 
ATOM   3385 C C   . HIS B 1 172 ? -3.916  24.832  8.155   1.00 14.41 ? 197 HIS B C   1 
ATOM   3386 O O   . HIS B 1 172 ? -4.231  25.257  9.275   1.00 15.07 ? 197 HIS B O   1 
ATOM   3387 C CB  . HIS B 1 172 ? -1.486  24.928  8.801   1.00 19.58 ? 197 HIS B CB  1 
ATOM   3388 C CG  . HIS B 1 172 ? -0.198  24.168  8.876   1.00 22.71 ? 197 HIS B CG  1 
ATOM   3389 N ND1 . HIS B 1 172 ? -0.099  22.926  9.466   1.00 33.78 ? 197 HIS B ND1 1 
ATOM   3390 C CD2 . HIS B 1 172 ? 1.041   24.467  8.418   1.00 39.31 ? 197 HIS B CD2 1 
ATOM   3391 C CE1 . HIS B 1 172 ? 1.147   22.496  9.376   1.00 38.51 ? 197 HIS B CE1 1 
ATOM   3392 N NE2 . HIS B 1 172 ? 1.859   23.413  8.746   1.00 35.70 ? 197 HIS B NE2 1 
ATOM   3393 N N   . ALA B 1 173 ? -4.778  24.818  7.136   1.00 10.44 ? 198 ALA B N   1 
ATOM   3394 C CA  . ALA B 1 173 ? -6.150  25.258  7.339   1.00 10.21 ? 198 ALA B CA  1 
ATOM   3395 C C   . ALA B 1 173 ? -6.915  24.289  8.226   1.00 12.55 ? 198 ALA B C   1 
ATOM   3396 O O   . ALA B 1 173 ? -7.832  24.698  8.939   1.00 14.44 ? 198 ALA B O   1 
ATOM   3397 C CB  . ALA B 1 173 ? -6.848  25.418  5.988   1.00 11.43 ? 198 ALA B CB  1 
ATOM   3398 N N   . LEU B 1 174 ? -6.547  23.015  8.194   1.00 10.44 ? 199 LEU B N   1 
ATOM   3399 C CA  . LEU B 1 174 ? -7.070  21.996  9.086   1.00 8.69  ? 199 LEU B CA  1 
ATOM   3400 C C   . LEU B 1 174 ? -5.979  21.507  10.028  1.00 10.10 ? 199 LEU B C   1 
ATOM   3401 O O   . LEU B 1 174 ? -4.779  21.657  9.759   1.00 11.91 ? 199 LEU B O   1 
ATOM   3402 C CB  . LEU B 1 174 ? -7.611  20.811  8.282   1.00 11.97 ? 199 LEU B CB  1 
ATOM   3403 C CG  . LEU B 1 174 ? -8.733  21.111  7.293   1.00 7.92  ? 199 LEU B CG  1 
ATOM   3404 C CD1 . LEU B 1 174 ? -9.030  19.839  6.492   1.00 8.55  ? 199 LEU B CD1 1 
ATOM   3405 C CD2 . LEU B 1 174 ? -9.972  21.578  8.003   1.00 12.40 ? 199 LEU B CD2 1 
ATOM   3406 N N   . GLY B 1 175 ? -6.406  20.875  11.122  1.00 10.84 ? 200 GLY B N   1 
ATOM   3407 C CA  . GLY B 1 175 ? -5.462  20.144  11.952  1.00 11.87 ? 200 GLY B CA  1 
ATOM   3408 C C   . GLY B 1 175 ? -4.828  18.989  11.199  1.00 11.86 ? 200 GLY B C   1 
ATOM   3409 O O   . GLY B 1 175 ? -5.332  18.528  10.185  1.00 10.71 ? 200 GLY B O   1 
ATOM   3410 N N   . GLU B 1 176 ? -3.684  18.521  11.704  1.00 12.85 ? 201 GLU B N   1 
ATOM   3411 C CA  . GLU B 1 176 ? -2.904  17.512  10.982  1.00 12.57 ? 201 GLU B CA  1 
ATOM   3412 C C   . GLU B 1 176 ? -3.715  16.248  10.708  1.00 14.64 ? 201 GLU B C   1 
ATOM   3413 O O   . GLU B 1 176 ? -3.671  15.702  9.599   1.00 14.02 ? 201 GLU B O   1 
ATOM   3414 C CB  . GLU B 1 176 ? -1.642  17.162  11.773  1.00 17.44 ? 201 GLU B CB  1 
ATOM   3415 C CG  . GLU B 1 176 ? -0.355  17.259  10.977  1.00 40.64 ? 201 GLU B CG  1 
ATOM   3416 C CD  . GLU B 1 176 ? 0.830   17.659  11.832  1.00 58.32 ? 201 GLU B CD  1 
ATOM   3417 O OE1 . GLU B 1 176 ? 1.389   18.757  11.604  1.00 53.60 ? 201 GLU B OE1 1 
ATOM   3418 O OE2 . GLU B 1 176 ? 1.197   16.872  12.734  1.00 57.40 ? 201 GLU B OE2 1 
ATOM   3419 N N   . THR B 1 177 ? -4.430  15.748  11.719  1.00 14.76 ? 202 THR B N   1 
ATOM   3420 C CA  . THR B 1 177 ? -5.231  14.538  11.544  1.00 11.17 ? 202 THR B CA  1 
ATOM   3421 C C   . THR B 1 177 ? -6.341  14.762  10.519  1.00 11.67 ? 202 THR B C   1 
ATOM   3422 O O   . THR B 1 177 ? -6.640  13.882  9.697   1.00 12.74 ? 202 THR B O   1 
ATOM   3423 C CB  . THR B 1 177 ? -5.822  14.118  12.892  1.00 20.70 ? 202 THR B CB  1 
ATOM   3424 O OG1 . THR B 1 177 ? -4.766  13.684  13.762  1.00 27.35 ? 202 THR B OG1 1 
ATOM   3425 C CG2 . THR B 1 177 ? -6.842  12.999  12.718  1.00 29.18 ? 202 THR B CG2 1 
ATOM   3426 N N   . GLN B 1 178 ? -6.956  15.942  10.553  1.00 11.76 ? 203 GLN B N   1 
ATOM   3427 C CA  . GLN B 1 178 ? -8.050  16.243  9.639   1.00 9.85  ? 203 GLN B CA  1 
ATOM   3428 C C   . GLN B 1 178 ? -7.547  16.426  8.216   1.00 12.55 ? 203 GLN B C   1 
ATOM   3429 O O   . GLN B 1 178 ? -8.188  15.966  7.265   1.00 10.91 ? 203 GLN B O   1 
ATOM   3430 C CB  . GLN B 1 178 ? -8.780  17.499  10.121  1.00 10.89 ? 203 GLN B CB  1 
ATOM   3431 C CG  . GLN B 1 178 ? -9.581  17.281  11.401  1.00 9.70  ? 203 GLN B CG  1 
ATOM   3432 C CD  . GLN B 1 178 ? -8.724  17.212  12.663  1.00 9.90  ? 203 GLN B CD  1 
ATOM   3433 O OE1 . GLN B 1 178 ? -7.654  17.806  12.738  1.00 11.89 ? 203 GLN B OE1 1 
ATOM   3434 N NE2 . GLN B 1 178 ? -9.202  16.476  13.660  1.00 14.84 ? 203 GLN B NE2 1 
ATOM   3435 N N   . ARG B 1 179 ? -6.408  17.104  8.055   1.00 11.26 ? 204 ARG B N   1 
ATOM   3436 C CA  . ARG B 1 179 ? -5.774  17.221  6.744   1.00 9.94  ? 204 ARG B CA  1 
ATOM   3437 C C   . ARG B 1 179 ? -5.479  15.848  6.163   1.00 10.46 ? 204 ARG B C   1 
ATOM   3438 O O   . ARG B 1 179 ? -5.736  15.599  4.980   1.00 10.92 ? 204 ARG B O   1 
ATOM   3439 C CB  . ARG B 1 179 ? -4.490  18.042  6.858   1.00 10.66 ? 204 ARG B CB  1 
ATOM   3440 C CG  . ARG B 1 179 ? -3.668  18.090  5.582   1.00 12.84 ? 204 ARG B CG  1 
ATOM   3441 C CD  . ARG B 1 179 ? -2.429  18.935  5.757   1.00 14.54 ? 204 ARG B CD  1 
ATOM   3442 N NE  . ARG B 1 179 ? -1.482  18.331  6.685   1.00 19.38 ? 204 ARG B NE  1 
ATOM   3443 C CZ  . ARG B 1 179 ? -0.271  18.805  6.942   1.00 26.02 ? 204 ARG B CZ  1 
ATOM   3444 N NH1 . ARG B 1 179 ? 0.146   19.950  6.426   1.00 21.56 ? 204 ARG B NH1 1 
ATOM   3445 N NH2 . ARG B 1 179 ? 0.541   18.114  7.740   1.00 26.93 ? 204 ARG B NH2 1 
ATOM   3446 N N   . ALA B 1 180 ? -4.951  14.937  6.987   1.00 12.21 ? 205 ALA B N   1 
ATOM   3447 C CA  . ALA B 1 180 ? -4.661  13.588  6.515   1.00 9.78  ? 205 ALA B CA  1 
ATOM   3448 C C   . ALA B 1 180 ? -5.938  12.875  6.091   1.00 11.11 ? 205 ALA B C   1 
ATOM   3449 O O   . ALA B 1 180 ? -5.949  12.155  5.084   1.00 10.47 ? 205 ALA B O   1 
ATOM   3450 C CB  . ALA B 1 180 ? -3.930  12.801  7.600   1.00 11.20 ? 205 ALA B CB  1 
ATOM   3451 N N   . GLN B 1 181 ? -7.023  13.052  6.853   1.00 9.11  ? 206 GLN B N   1 
ATOM   3452 C CA  . GLN B 1 181 ? -8.286  12.417  6.494   1.00 7.41  ? 206 GLN B CA  1 
ATOM   3453 C C   . GLN B 1 181 ? -8.802  12.939  5.159   1.00 10.15 ? 206 GLN B C   1 
ATOM   3454 O O   . GLN B 1 181 ? -9.286  12.164  4.325   1.00 10.51 ? 206 GLN B O   1 
ATOM   3455 C CB  . GLN B 1 181 ? -9.315  12.652  7.598   1.00 9.84  ? 206 GLN B CB  1 
ATOM   3456 C CG  . GLN B 1 181 ? -10.693 12.028  7.332   1.00 9.83  ? 206 GLN B CG  1 
ATOM   3457 C CD  . GLN B 1 181 ? -10.643 10.515  7.232   1.00 13.69 ? 206 GLN B CD  1 
ATOM   3458 O OE1 . GLN B 1 181 ? -10.740 9.820   8.242   1.00 16.61 ? 206 GLN B OE1 1 
ATOM   3459 N NE2 . GLN B 1 181 ? -10.501 9.996   6.019   1.00 12.20 ? 206 GLN B NE2 1 
ATOM   3460 N N   . LEU B 1 182 ? -8.734  14.257  4.951   1.00 11.08 ? 207 LEU B N   1 
ATOM   3461 C CA  . LEU B 1 182 ? -9.171  14.820  3.677   1.00 8.10  ? 207 LEU B CA  1 
ATOM   3462 C C   . LEU B 1 182 ? -8.342  14.276  2.521   1.00 9.48  ? 207 LEU B C   1 
ATOM   3463 O O   . LEU B 1 182 ? -8.891  13.903  1.482   1.00 10.12 ? 207 LEU B O   1 
ATOM   3464 C CB  . LEU B 1 182 ? -9.101  16.346  3.726   1.00 7.32  ? 207 LEU B CB  1 
ATOM   3465 C CG  . LEU B 1 182 ? -9.545  17.056  2.443   1.00 7.34  ? 207 LEU B CG  1 
ATOM   3466 C CD1 . LEU B 1 182 ? -10.995 16.669  2.133   1.00 12.00 ? 207 LEU B CD1 1 
ATOM   3467 C CD2 . LEU B 1 182 ? -9.396  18.576  2.542   1.00 9.10  ? 207 LEU B CD2 1 
ATOM   3468 N N   . VAL B 1 183 ? -7.022  14.211  2.688   1.00 8.38  ? 208 VAL B N   1 
ATOM   3469 C CA  . VAL B 1 183 ? -6.175  13.675  1.625   1.00 8.11  ? 208 VAL B CA  1 
ATOM   3470 C C   . VAL B 1 183 ? -6.519  12.212  1.351   1.00 9.75  ? 208 VAL B C   1 
ATOM   3471 O O   . VAL B 1 183 ? -6.635  11.797  0.191   1.00 9.75  ? 208 VAL B O   1 
ATOM   3472 C CB  . VAL B 1 183 ? -4.689  13.864  1.981   1.00 9.67  ? 208 VAL B CB  1 
ATOM   3473 C CG1 . VAL B 1 183 ? -3.816  13.021  1.073   1.00 10.75 ? 208 VAL B CG1 1 
ATOM   3474 C CG2 . VAL B 1 183 ? -4.310  15.346  1.881   1.00 10.87 ? 208 VAL B CG2 1 
ATOM   3475 N N   . THR B 1 184 ? -6.708  11.415  2.409   1.00 11.58 ? 209 THR B N   1 
ATOM   3476 C CA  . THR B 1 184 ? -7.099  10.016  2.239   1.00 12.27 ? 209 THR B CA  1 
ATOM   3477 C C   . THR B 1 184 ? -8.383  9.899   1.428   1.00 7.66  ? 209 THR B C   1 
ATOM   3478 O O   . THR B 1 184 ? -8.477  9.085   0.502   1.00 10.72 ? 209 THR B O   1 
ATOM   3479 C CB  . THR B 1 184 ? -7.276  9.352   3.607   1.00 11.92 ? 209 THR B CB  1 
ATOM   3480 O OG1 . THR B 1 184 ? -5.997  9.221   4.240   1.00 13.92 ? 209 THR B OG1 1 
ATOM   3481 C CG2 . THR B 1 184 ? -7.929  7.972   3.455   1.00 13.20 ? 209 THR B CG2 1 
ATOM   3482 N N   . TRP B 1 185 ? -9.391  10.708  1.765   1.00 8.86  ? 210 TRP B N   1 
ATOM   3483 C CA  . TRP B 1 185 ? -10.646 10.654  1.025   1.00 7.75  ? 210 TRP B CA  1 
ATOM   3484 C C   . TRP B 1 185 ? -10.441 11.017  -0.446  1.00 10.33 ? 210 TRP B C   1 
ATOM   3485 O O   . TRP B 1 185 ? -10.936 10.324  -1.343  1.00 9.90  ? 210 TRP B O   1 
ATOM   3486 C CB  . TRP B 1 185 ? -11.667 11.584  1.675   1.00 8.23  ? 210 TRP B CB  1 
ATOM   3487 C CG  . TRP B 1 185 ? -12.322 11.032  2.923   1.00 8.23  ? 210 TRP B CG  1 
ATOM   3488 C CD1 . TRP B 1 185 ? -12.537 9.713   3.235   1.00 10.94 ? 210 TRP B CD1 1 
ATOM   3489 C CD2 . TRP B 1 185 ? -12.877 11.792  4.005   1.00 9.19  ? 210 TRP B CD2 1 
ATOM   3490 N NE1 . TRP B 1 185 ? -13.179 9.616   4.453   1.00 12.07 ? 210 TRP B NE1 1 
ATOM   3491 C CE2 . TRP B 1 185 ? -13.398 10.878  4.940   1.00 12.90 ? 210 TRP B CE2 1 
ATOM   3492 C CE3 . TRP B 1 185 ? -12.977 13.167  4.274   1.00 9.90  ? 210 TRP B CE3 1 
ATOM   3493 C CZ2 . TRP B 1 185 ? -14.012 11.289  6.117   1.00 11.34 ? 210 TRP B CZ2 1 
ATOM   3494 C CZ3 . TRP B 1 185 ? -13.589 13.572  5.445   1.00 10.87 ? 210 TRP B CZ3 1 
ATOM   3495 C CH2 . TRP B 1 185 ? -14.096 12.638  6.352   1.00 8.96  ? 210 TRP B CH2 1 
ATOM   3496 N N   . LEU B 1 186 ? -9.726  12.115  -0.713  1.00 8.71  ? 211 LEU B N   1 
ATOM   3497 C CA  . LEU B 1 186 ? -9.511  12.558  -2.090  1.00 8.41  ? 211 LEU B CA  1 
ATOM   3498 C C   . LEU B 1 186 ? -8.754  11.519  -2.894  1.00 8.43  ? 211 LEU B C   1 
ATOM   3499 O O   . LEU B 1 186 ? -9.079  11.276  -4.063  1.00 7.87  ? 211 LEU B O   1 
ATOM   3500 C CB  . LEU B 1 186 ? -8.748  13.881  -2.113  1.00 9.67  ? 211 LEU B CB  1 
ATOM   3501 C CG  . LEU B 1 186 ? -9.514  15.064  -1.528  1.00 10.29 ? 211 LEU B CG  1 
ATOM   3502 C CD1 . LEU B 1 186 ? -8.556  16.227  -1.420  1.00 11.40 ? 211 LEU B CD1 1 
ATOM   3503 C CD2 . LEU B 1 186 ? -10.736 15.396  -2.384  1.00 12.78 ? 211 LEU B CD2 1 
ATOM   3504 N N   . LYS B 1 187 ? -7.737  10.889  -2.286  1.00 10.02 ? 212 LYS B N   1 
ATOM   3505 C CA  . LYS B 1 187 ? -7.000  9.872   -3.032  1.00 8.20  ? 212 LYS B CA  1 
ATOM   3506 C C   . LYS B 1 187 ? -7.843  8.653   -3.351  1.00 10.90 ? 212 LYS B C   1 
ATOM   3507 O O   . LYS B 1 187 ? -7.562  7.976   -4.349  1.00 11.70 ? 212 LYS B O   1 
ATOM   3508 C CB  . LYS B 1 187 ? -5.715  9.404   -2.342  1.00 12.14 ? 212 LYS B CB  1 
ATOM   3509 C CG  . LYS B 1 187 ? -4.580  10.427  -2.223  1.00 12.86 ? 212 LYS B CG  1 
ATOM   3510 C CD  . LYS B 1 187 ? -3.598  9.986   -1.135  1.00 17.55 ? 212 LYS B CD  1 
ATOM   3511 C CE  . LYS B 1 187 ? -2.335  10.828  -1.149  1.00 21.54 ? 212 LYS B CE  1 
ATOM   3512 N NZ  . LYS B 1 187 ? -1.376  10.348  -0.110  1.00 37.06 ? 212 LYS B NZ  1 
ATOM   3513 N N   . GLY B 1 188 ? -8.887  8.386   -2.578  1.00 8.62  ? 213 GLY B N   1 
ATOM   3514 C CA  . GLY B 1 188 ? -9.780  7.284   -2.867  1.00 8.20  ? 213 GLY B CA  1 
ATOM   3515 C C   . GLY B 1 188 ? -10.978 7.626   -3.725  1.00 6.39  ? 213 GLY B C   1 
ATOM   3516 O O   . GLY B 1 188 ? -11.900 6.815   -3.842  1.00 8.74  ? 213 GLY B O   1 
ATOM   3517 N N   . ASN B 1 189 ? -10.990 8.797   -4.366  1.00 7.14  ? 214 ASN B N   1 
ATOM   3518 C CA  . ASN B 1 189 ? -12.083 9.132   -5.262  1.00 6.57  ? 214 ASN B CA  1 
ATOM   3519 C C   . ASN B 1 189 ? -12.264 8.076   -6.354  1.00 6.81  ? 214 ASN B C   1 
ATOM   3520 O O   . ASN B 1 189 ? -11.289 7.562   -6.917  1.00 9.45  ? 214 ASN B O   1 
ATOM   3521 C CB  . ASN B 1 189 ? -11.826 10.491  -5.911  1.00 8.25  ? 214 ASN B CB  1 
ATOM   3522 C CG  . ASN B 1 189 ? -12.938 10.881  -6.841  1.00 7.87  ? 214 ASN B CG  1 
ATOM   3523 O OD1 . ASN B 1 189 ? -14.101 10.550  -6.604  1.00 9.69  ? 214 ASN B OD1 1 
ATOM   3524 N ND2 . ASN B 1 189 ? -12.596 11.591  -7.916  1.00 9.18  ? 214 ASN B ND2 1 
ATOM   3525 N N   . THR B 1 190 ? -13.531 7.743   -6.647  1.00 7.83  ? 215 THR B N   1 
ATOM   3526 C CA  . THR B 1 190 ? -13.803 6.773   -7.702  1.00 7.09  ? 215 THR B CA  1 
ATOM   3527 C C   . THR B 1 190 ? -14.086 7.404   -9.055  1.00 9.54  ? 215 THR B C   1 
ATOM   3528 O O   . THR B 1 190 ? -14.139 6.676   -10.046 1.00 9.56  ? 215 THR B O   1 
ATOM   3529 C CB  . THR B 1 190 ? -14.987 5.873   -7.333  1.00 7.93  ? 215 THR B CB  1 
ATOM   3530 O OG1 . THR B 1 190 ? -16.216 6.625   -7.333  1.00 9.90  ? 215 THR B OG1 1 
ATOM   3531 C CG2 . THR B 1 190 ? -14.747 5.217   -5.965  1.00 11.13 ? 215 THR B CG2 1 
ATOM   3532 N N   . THR B 1 191 ? -14.258 8.721   -9.139  1.00 8.01  ? 216 THR B N   1 
ATOM   3533 C CA  . THR B 1 191 ? -14.872 9.327   -10.320 1.00 9.54  ? 216 THR B CA  1 
ATOM   3534 C C   . THR B 1 191 ? -13.887 10.056  -11.209 1.00 8.15  ? 216 THR B C   1 
ATOM   3535 O O   . THR B 1 191 ? -14.318 10.694  -12.173 1.00 9.43  ? 216 THR B O   1 
ATOM   3536 C CB  . THR B 1 191 ? -15.976 10.318  -9.920  1.00 10.31 ? 216 THR B CB  1 
ATOM   3537 O OG1 . THR B 1 191 ? -15.388 11.461  -9.282  1.00 10.62 ? 216 THR B OG1 1 
ATOM   3538 C CG2 . THR B 1 191 ? -16.992 9.678   -8.991  1.00 11.56 ? 216 THR B CG2 1 
ATOM   3539 N N   . GLY B 1 192 ? -12.589 9.991   -10.923 1.00 7.12  ? 217 GLY B N   1 
ATOM   3540 C CA  . GLY B 1 192 ? -11.647 10.923  -11.514 1.00 8.40  ? 217 GLY B CA  1 
ATOM   3541 C C   . GLY B 1 192 ? -10.756 10.455  -12.651 1.00 7.62  ? 217 GLY B C   1 
ATOM   3542 O O   . GLY B 1 192 ? -10.010 11.277  -13.196 1.00 9.63  ? 217 GLY B O   1 
ATOM   3543 N N   . ALA B 1 193 ? -10.815 9.186   -13.059 1.00 7.00  ? 218 ALA B N   1 
ATOM   3544 C CA  . ALA B 1 193 ? -9.776  8.677   -13.952 1.00 9.73  ? 218 ALA B CA  1 
ATOM   3545 C C   . ALA B 1 193 ? -9.819  9.269   -15.357 1.00 10.62 ? 218 ALA B C   1 
ATOM   3546 O O   . ALA B 1 193 ? -8.828  9.134   -16.083 1.00 11.48 ? 218 ALA B O   1 
ATOM   3547 C CB  . ALA B 1 193 ? -9.864  7.149   -14.056 1.00 9.48  ? 218 ALA B CB  1 
ATOM   3548 N N   . ALA B 1 194 ? -10.943 9.864   -15.777 1.00 9.44  ? 219 ALA B N   1 
ATOM   3549 C CA  . ALA B 1 194 ? -11.056 10.438  -17.114 1.00 10.02 ? 219 ALA B CA  1 
ATOM   3550 C C   . ALA B 1 194 ? -10.739 11.925  -17.150 1.00 8.25  ? 219 ALA B C   1 
ATOM   3551 O O   . ALA B 1 194 ? -10.742 12.519  -18.232 1.00 10.04 ? 219 ALA B O   1 
ATOM   3552 C CB  . ALA B 1 194 ? -12.469 10.217  -17.676 1.00 9.57  ? 219 ALA B CB  1 
ATOM   3553 N N   . SER B 1 195 ? -10.467 12.539  -16.012 1.00 8.31  ? 220 SER B N   1 
ATOM   3554 C CA  . SER B 1 195 ? -10.369 13.994  -15.908 1.00 9.19  ? 220 SER B CA  1 
ATOM   3555 C C   . SER B 1 195 ? -8.892  14.376  -15.765 1.00 6.38  ? 220 SER B C   1 
ATOM   3556 O O   . SER B 1 195 ? -8.100  13.958  -16.610 1.00 8.78  ? 220 SER B O   1 
ATOM   3557 C CB  . SER B 1 195 ? -11.276 14.473  -14.790 1.00 7.64  ? 220 SER B CB  1 
ATOM   3558 O OG  . SER B 1 195 ? -12.604 14.147  -15.134 1.00 8.66  ? 220 SER B OG  1 
ATOM   3559 N N   . ILE B 1 196 ? -8.492  15.149  -14.747 1.00 9.13  ? 221 ILE B N   1 
ATOM   3560 C CA  . ILE B 1 196 ? -7.096  15.569  -14.616 1.00 10.73 ? 221 ILE B CA  1 
ATOM   3561 C C   . ILE B 1 196 ? -6.154  14.369  -14.664 1.00 11.65 ? 221 ILE B C   1 
ATOM   3562 O O   . ILE B 1 196 ? -5.116  14.398  -15.343 1.00 12.55 ? 221 ILE B O   1 
ATOM   3563 C CB  . ILE B 1 196 ? -6.916  16.382  -13.316 1.00 8.75  ? 221 ILE B CB  1 
ATOM   3564 C CG1 . ILE B 1 196 ? -7.450  17.803  -13.500 1.00 9.08  ? 221 ILE B CG1 1 
ATOM   3565 C CG2 . ILE B 1 196 ? -5.423  16.442  -12.913 1.00 10.51 ? 221 ILE B CG2 1 
ATOM   3566 C CD1 . ILE B 1 196 ? -7.575  18.585  -12.186 1.00 9.34  ? 221 ILE B CD1 1 
ATOM   3567 N N   A ARG B 1 197 ? -6.507  13.298  -13.943 0.52 12.03 ? 222 ARG B N   1 
ATOM   3568 N N   B ARG B 1 197 ? -6.507  13.293  -13.954 0.48 12.04 ? 222 ARG B N   1 
ATOM   3569 C CA  A ARG B 1 197 ? -5.694  12.084  -13.897 0.52 12.87 ? 222 ARG B CA  1 
ATOM   3570 C CA  B ARG B 1 197 ? -5.664  12.098  -13.903 0.48 12.84 ? 222 ARG B CA  1 
ATOM   3571 C C   A ARG B 1 197 ? -5.304  11.598  -15.288 0.52 13.36 ? 222 ARG B C   1 
ATOM   3572 C C   B ARG B 1 197 ? -5.301  11.584  -15.292 0.48 13.36 ? 222 ARG B C   1 
ATOM   3573 O O   A ARG B 1 197 ? -4.179  11.129  -15.501 0.52 13.38 ? 222 ARG B O   1 
ATOM   3574 O O   B ARG B 1 197 ? -4.191  11.084  -15.508 0.48 13.39 ? 222 ARG B O   1 
ATOM   3575 C CB  A ARG B 1 197 ? -6.467  10.982  -13.170 0.52 12.68 ? 222 ARG B CB  1 
ATOM   3576 C CB  B ARG B 1 197 ? -6.382  11.004  -13.114 0.48 12.69 ? 222 ARG B CB  1 
ATOM   3577 C CG  A ARG B 1 197 ? -6.293  10.922  -11.662 0.52 19.96 ? 222 ARG B CG  1 
ATOM   3578 C CG  B ARG B 1 197 ? -5.492  9.864   -12.647 0.48 21.28 ? 222 ARG B CG  1 
ATOM   3579 C CD  A ARG B 1 197 ? -7.388  10.047  -11.066 0.52 19.38 ? 222 ARG B CD  1 
ATOM   3580 C CD  B ARG B 1 197 ? -6.339  8.728   -12.092 0.48 20.38 ? 222 ARG B CD  1 
ATOM   3581 N NE  A ARG B 1 197 ? -7.871  10.524  -9.776  0.52 20.08 ? 222 ARG B NE  1 
ATOM   3582 N NE  B ARG B 1 197 ? -5.704  7.428   -12.282 0.48 26.82 ? 222 ARG B NE  1 
ATOM   3583 C CZ  A ARG B 1 197 ? -7.519  10.004  -8.609  0.52 14.84 ? 222 ARG B CZ  1 
ATOM   3584 C CZ  B ARG B 1 197 ? -5.496  6.552   -11.309 0.48 22.78 ? 222 ARG B CZ  1 
ATOM   3585 N NH1 A ARG B 1 197 ? -6.690  8.973   -8.534  0.52 19.24 ? 222 ARG B NH1 1 
ATOM   3586 N NH1 B ARG B 1 197 ? -5.912  6.778   -10.074 0.48 22.33 ? 222 ARG B NH1 1 
ATOM   3587 N NH2 A ARG B 1 197 ? -8.020  10.521  -7.489  0.52 14.91 ? 222 ARG B NH2 1 
ATOM   3588 N NH2 B ARG B 1 197 ? -4.868  5.411   -11.586 0.48 28.40 ? 222 ARG B NH2 1 
ATOM   3589 N N   . ALA B 1 198 ? -6.223  11.700  -16.246 1.00 10.23 ? 223 ALA B N   1 
ATOM   3590 C CA  . ALA B 1 198 ? -5.993  11.152  -17.578 1.00 11.25 ? 223 ALA B CA  1 
ATOM   3591 C C   . ALA B 1 198 ? -4.931  11.919  -18.356 1.00 12.97 ? 223 ALA B C   1 
ATOM   3592 O O   . ALA B 1 198 ? -4.379  11.379  -19.321 1.00 17.14 ? 223 ALA B O   1 
ATOM   3593 C CB  . ALA B 1 198 ? -7.303  11.126  -18.361 1.00 14.29 ? 223 ALA B CB  1 
ATOM   3594 N N   . GLY B 1 199 ? -4.639  13.157  -17.974 1.00 10.86 ? 224 GLY B N   1 
ATOM   3595 C CA  . GLY B 1 199 ? -3.623  13.921  -18.660 1.00 9.98  ? 224 GLY B CA  1 
ATOM   3596 C C   . GLY B 1 199 ? -2.256  13.860  -18.040 1.00 11.87 ? 224 GLY B C   1 
ATOM   3597 O O   . GLY B 1 199 ? -1.332  14.477  -18.575 1.00 14.32 ? 224 GLY B O   1 
ATOM   3598 N N   . LEU B 1 200 ? -2.084  13.123  -16.943 1.00 11.89 ? 225 LEU B N   1 
ATOM   3599 C CA  . LEU B 1 200 ? -0.841  13.088  -16.190 1.00 15.66 ? 225 LEU B CA  1 
ATOM   3600 C C   . LEU B 1 200 ? -0.143  11.743  -16.341 1.00 17.87 ? 225 LEU B C   1 
ATOM   3601 O O   . LEU B 1 200 ? -0.783  10.731  -16.646 1.00 18.89 ? 225 LEU B O   1 
ATOM   3602 C CB  . LEU B 1 200 ? -1.114  13.358  -14.704 1.00 17.71 ? 225 LEU B CB  1 
ATOM   3603 C CG  . LEU B 1 200 ? -1.803  14.688  -14.380 1.00 16.42 ? 225 LEU B CG  1 
ATOM   3604 C CD1 . LEU B 1 200 ? -2.061  14.802  -12.878 1.00 17.47 ? 225 LEU B CD1 1 
ATOM   3605 C CD2 . LEU B 1 200 ? -0.959  15.855  -14.898 1.00 16.98 ? 225 LEU B CD2 1 
ATOM   3606 N N   . PRO B 1 201 ? 1.174   11.695  -16.133 1.00 19.79 ? 226 PRO B N   1 
ATOM   3607 C CA  . PRO B 1 201 ? 1.861   10.397  -16.108 1.00 22.30 ? 226 PRO B CA  1 
ATOM   3608 C C   . PRO B 1 201 ? 1.223   9.480   -15.074 1.00 26.72 ? 226 PRO B C   1 
ATOM   3609 O O   . PRO B 1 201 ? 0.881   9.902   -13.968 1.00 21.75 ? 226 PRO B O   1 
ATOM   3610 C CB  . PRO B 1 201 ? 3.301   10.761  -15.729 1.00 21.23 ? 226 PRO B CB  1 
ATOM   3611 C CG  . PRO B 1 201 ? 3.460   12.187  -16.143 1.00 24.60 ? 226 PRO B CG  1 
ATOM   3612 C CD  . PRO B 1 201 ? 2.100   12.829  -15.986 1.00 20.68 ? 226 PRO B CD  1 
ATOM   3613 N N   . THR B 1 202 ? 1.046   8.212   -15.447 1.00 26.30 ? 227 THR B N   1 
ATOM   3614 C CA  . THR B 1 202 ? 0.351   7.293   -14.553 1.00 26.77 ? 227 THR B CA  1 
ATOM   3615 C C   . THR B 1 202 ? 1.107   7.062   -13.249 1.00 22.29 ? 227 THR B C   1 
ATOM   3616 O O   . THR B 1 202 ? 0.481   6.713   -12.247 1.00 26.82 ? 227 THR B O   1 
ATOM   3617 C CB  . THR B 1 202 ? 0.087   5.964   -15.261 1.00 38.59 ? 227 THR B CB  1 
ATOM   3618 O OG1 . THR B 1 202 ? 1.322   5.423   -15.744 1.00 44.77 ? 227 THR B OG1 1 
ATOM   3619 C CG2 . THR B 1 202 ? -0.882  6.160   -16.421 1.00 30.33 ? 227 THR B CG2 1 
ATOM   3620 N N   . SER B 1 203 ? 2.425   7.288   -13.225 1.00 21.81 ? 228 SER B N   1 
ATOM   3621 C CA  . SER B 1 203 ? 3.182   7.115   -11.987 1.00 26.90 ? 228 SER B CA  1 
ATOM   3622 C C   . SER B 1 203 ? 2.836   8.166   -10.940 1.00 26.07 ? 228 SER B C   1 
ATOM   3623 O O   . SER B 1 203 ? 3.113   7.953   -9.753  1.00 26.29 ? 228 SER B O   1 
ATOM   3624 C CB  . SER B 1 203 ? 4.687   7.169   -12.256 1.00 20.88 ? 228 SER B CB  1 
ATOM   3625 O OG  . SER B 1 203 ? 5.046   8.385   -12.884 1.00 31.68 ? 228 SER B OG  1 
ATOM   3626 N N   . TRP B 1 204 ? 2.250   9.293   -11.345 1.00 21.86 ? 229 TRP B N   1 
ATOM   3627 C CA  . TRP B 1 204 ? 1.948   10.366  -10.413 1.00 21.97 ? 229 TRP B CA  1 
ATOM   3628 C C   . TRP B 1 204 ? 0.722   9.984   -9.584  1.00 20.43 ? 229 TRP B C   1 
ATOM   3629 O O   . TRP B 1 204 ? -0.194  9.317   -10.071 1.00 25.43 ? 229 TRP B O   1 
ATOM   3630 C CB  . TRP B 1 204 ? 1.675   11.671  -11.166 1.00 19.95 ? 229 TRP B CB  1 
ATOM   3631 C CG  . TRP B 1 204 ? 2.876   12.257  -11.879 1.00 21.14 ? 229 TRP B CG  1 
ATOM   3632 C CD1 . TRP B 1 204 ? 4.074   11.638  -12.124 1.00 30.31 ? 229 TRP B CD1 1 
ATOM   3633 C CD2 . TRP B 1 204 ? 2.990   13.577  -12.435 1.00 16.41 ? 229 TRP B CD2 1 
ATOM   3634 N NE1 . TRP B 1 204 ? 4.916   12.485  -12.806 1.00 20.32 ? 229 TRP B NE1 1 
ATOM   3635 C CE2 . TRP B 1 204 ? 4.277   13.679  -13.013 1.00 18.42 ? 229 TRP B CE2 1 
ATOM   3636 C CE3 . TRP B 1 204 ? 2.129   14.680  -12.505 1.00 17.81 ? 229 TRP B CE3 1 
ATOM   3637 C CZ2 . TRP B 1 204 ? 4.722   14.840  -13.639 1.00 21.04 ? 229 TRP B CZ2 1 
ATOM   3638 C CZ3 . TRP B 1 204 ? 2.573   15.826  -13.135 1.00 22.76 ? 229 TRP B CZ3 1 
ATOM   3639 C CH2 . TRP B 1 204 ? 3.858   15.899  -13.692 1.00 26.55 ? 229 TRP B CH2 1 
ATOM   3640 N N   . THR B 1 205 ? 0.710   10.405  -8.325  1.00 15.07 ? 230 THR B N   1 
ATOM   3641 C CA  . THR B 1 205 ? -0.398  10.120  -7.418  1.00 19.17 ? 230 THR B CA  1 
ATOM   3642 C C   . THR B 1 205 ? -1.328  11.327  -7.356  1.00 16.68 ? 230 THR B C   1 
ATOM   3643 O O   . THR B 1 205 ? -0.868  12.468  -7.256  1.00 17.35 ? 230 THR B O   1 
ATOM   3644 C CB  . THR B 1 205 ? 0.117   9.771   -6.018  1.00 15.86 ? 230 THR B CB  1 
ATOM   3645 O OG1 . THR B 1 205 ? 0.745   8.483   -6.057  1.00 25.83 ? 230 THR B OG1 1 
ATOM   3646 C CG2 . THR B 1 205 ? -1.023  9.718   -5.006  1.00 19.29 ? 230 THR B CG2 1 
ATOM   3647 N N   . VAL B 1 206 ? -2.636  11.077  -7.431  1.00 16.31 ? 231 VAL B N   1 
ATOM   3648 C CA  . VAL B 1 206 ? -3.628  12.145  -7.517  1.00 13.03 ? 231 VAL B CA  1 
ATOM   3649 C C   . VAL B 1 206 ? -4.731  11.919  -6.494  1.00 11.60 ? 231 VAL B C   1 
ATOM   3650 O O   . VAL B 1 206 ? -5.238  10.802  -6.340  1.00 13.83 ? 231 VAL B O   1 
ATOM   3651 C CB  . VAL B 1 206 ? -4.235  12.231  -8.929  1.00 11.91 ? 231 VAL B CB  1 
ATOM   3652 C CG1 . VAL B 1 206 ? -5.316  13.341  -9.002  1.00 12.86 ? 231 VAL B CG1 1 
ATOM   3653 C CG2 . VAL B 1 206 ? -3.143  12.443  -9.967  1.00 16.81 ? 231 VAL B CG2 1 
ATOM   3654 N N   . GLY B 1 207 ? -5.113  12.992  -5.807  1.00 9.90  ? 232 GLY B N   1 
ATOM   3655 C CA  . GLY B 1 207 ? -6.367  13.022  -5.073  1.00 9.70  ? 232 GLY B CA  1 
ATOM   3656 C C   . GLY B 1 207 ? -7.208  14.112  -5.697  1.00 12.02 ? 232 GLY B C   1 
ATOM   3657 O O   . GLY B 1 207 ? -6.694  15.210  -5.927  1.00 13.50 ? 232 GLY B O   1 
ATOM   3658 N N   . ASP B 1 208 ? -8.476  13.851  -6.007  1.00 8.33  ? 233 ASP B N   1 
ATOM   3659 C CA  . ASP B 1 208 ? -9.230  14.832  -6.775  1.00 10.33 ? 233 ASP B CA  1 
ATOM   3660 C C   . ASP B 1 208 ? -10.705 14.758  -6.417  1.00 9.10  ? 233 ASP B C   1 
ATOM   3661 O O   . ASP B 1 208 ? -11.180 13.785  -5.822  1.00 7.99  ? 233 ASP B O   1 
ATOM   3662 C CB  . ASP B 1 208 ? -9.053  14.634  -8.298  1.00 9.03  ? 233 ASP B CB  1 
ATOM   3663 C CG  . ASP B 1 208 ? -9.985  13.561  -8.861  1.00 11.81 ? 233 ASP B CG  1 
ATOM   3664 O OD1 . ASP B 1 208 ? -9.790  12.380  -8.521  1.00 11.10 ? 233 ASP B OD1 1 
ATOM   3665 O OD2 . ASP B 1 208 ? -10.935 13.889  -9.628  1.00 9.45  ? 233 ASP B OD2 1 
ATOM   3666 N N   . LYS B 1 209 ? -11.428 15.802  -6.809  1.00 7.10  ? 234 LYS B N   1 
ATOM   3667 C CA  . LYS B 1 209 ? -12.881 15.809  -6.743  1.00 4.96  ? 234 LYS B CA  1 
ATOM   3668 C C   . LYS B 1 209 ? -13.418 16.387  -8.036  1.00 6.54  ? 234 LYS B C   1 
ATOM   3669 O O   . LYS B 1 209 ? -13.064 17.515  -8.401  1.00 6.62  ? 234 LYS B O   1 
ATOM   3670 C CB  . LYS B 1 209 ? -13.368 16.632  -5.552  1.00 6.26  ? 234 LYS B CB  1 
ATOM   3671 C CG  . LYS B 1 209 ? -14.892 16.685  -5.464  1.00 8.29  ? 234 LYS B CG  1 
ATOM   3672 C CD  . LYS B 1 209 ? -15.487 15.333  -5.023  1.00 8.32  ? 234 LYS B CD  1 
ATOM   3673 C CE  . LYS B 1 209 ? -16.990 15.275  -5.294  1.00 9.14  ? 234 LYS B CE  1 
ATOM   3674 N NZ  . LYS B 1 209 ? -17.274 14.822  -6.706  1.00 9.40  ? 234 LYS B NZ  1 
ATOM   3675 N N   . THR B 1 210 ? -14.250 15.617  -8.731  1.00 6.87  ? 235 THR B N   1 
ATOM   3676 C CA  . THR B 1 210 ? -14.864 16.049  -9.978  1.00 7.05  ? 235 THR B CA  1 
ATOM   3677 C C   . THR B 1 210 ? -16.166 16.799  -9.715  1.00 8.48  ? 235 THR B C   1 
ATOM   3678 O O   . THR B 1 210 ? -16.722 16.775  -8.617  1.00 8.04  ? 235 THR B O   1 
ATOM   3679 C CB  . THR B 1 210 ? -15.168 14.850  -10.873 1.00 10.65 ? 235 THR B CB  1 
ATOM   3680 O OG1 . THR B 1 210 ? -16.015 13.961  -10.142 1.00 9.65  ? 235 THR B OG1 1 
ATOM   3681 C CG2 . THR B 1 210 ? -13.889 14.105  -11.302 1.00 8.74  ? 235 THR B CG2 1 
ATOM   3682 N N   . GLY B 1 211 ? -16.659 17.463  -10.749 1.00 7.86  ? 236 GLY B N   1 
ATOM   3683 C CA  . GLY B 1 211 ? -18.000 18.025  -10.708 1.00 9.51  ? 236 GLY B CA  1 
ATOM   3684 C C   . GLY B 1 211 ? -18.578 18.042  -12.103 1.00 7.63  ? 236 GLY B C   1 
ATOM   3685 O O   . GLY B 1 211 ? -17.852 18.156  -13.095 1.00 10.34 ? 236 GLY B O   1 
ATOM   3686 N N   . SER B 1 212 ? -19.899 17.937  -12.178 1.00 10.14 ? 237 SER B N   1 
ATOM   3687 C CA  . SER B 1 212 ? -20.574 18.049  -13.457 1.00 10.07 ? 237 SER B CA  1 
ATOM   3688 C C   . SER B 1 212 ? -21.924 18.695  -13.215 1.00 10.44 ? 237 SER B C   1 
ATOM   3689 O O   . SER B 1 212 ? -22.491 18.581  -12.122 1.00 11.97 ? 237 SER B O   1 
ATOM   3690 C CB  . SER B 1 212 ? -20.736 16.682  -14.127 1.00 17.71 ? 237 SER B CB  1 
ATOM   3691 O OG  . SER B 1 212 ? -21.536 15.837  -13.334 1.00 22.70 ? 237 SER B OG  1 
ATOM   3692 N N   . GLY B 1 213 ? -22.417 19.405  -14.220 1.00 9.32  ? 238 GLY B N   1 
ATOM   3693 C CA  . GLY B 1 213 ? -23.692 20.066  -14.090 1.00 9.74  ? 238 GLY B CA  1 
ATOM   3694 C C   . GLY B 1 213 ? -24.275 20.407  -15.443 1.00 10.65 ? 238 GLY B C   1 
ATOM   3695 O O   . GLY B 1 213 ? -23.783 19.965  -16.483 1.00 11.49 ? 238 GLY B O   1 
ATOM   3696 N N   . ASP B 1 214 ? -25.339 21.209  -15.415 1.00 8.97  ? 240 ASP B N   1 
ATOM   3697 C CA  . ASP B 1 214 ? -25.925 21.696  -16.654 1.00 7.61  ? 240 ASP B CA  1 
ATOM   3698 C C   . ASP B 1 214 ? -24.911 22.568  -17.406 1.00 8.27  ? 240 ASP B C   1 
ATOM   3699 O O   . ASP B 1 214 ? -23.810 22.870  -16.916 1.00 10.11 ? 240 ASP B O   1 
ATOM   3700 C CB  . ASP B 1 214 ? -27.202 22.487  -16.366 1.00 7.90  ? 240 ASP B CB  1 
ATOM   3701 C CG  . ASP B 1 214 ? -28.373 21.608  -15.944 1.00 14.52 ? 240 ASP B CG  1 
ATOM   3702 O OD1 . ASP B 1 214 ? -28.251 20.362  -15.970 1.00 17.07 ? 240 ASP B OD1 1 
ATOM   3703 O OD2 . ASP B 1 214 ? -29.439 22.182  -15.590 1.00 17.61 ? 240 ASP B OD2 1 
ATOM   3704 N N   . TYR B 1 215 ? -25.280 22.935  -18.636 1.00 8.19  ? 241 TYR B N   1 
ATOM   3705 C CA  . TYR B 1 215 ? -24.399 23.653  -19.559 1.00 8.98  ? 241 TYR B CA  1 
ATOM   3706 C C   . TYR B 1 215 ? -23.108 22.875  -19.807 1.00 9.47  ? 241 TYR B C   1 
ATOM   3707 O O   . TYR B 1 215 ? -22.041 23.448  -20.036 1.00 9.40  ? 241 TYR B O   1 
ATOM   3708 C CB  . TYR B 1 215 ? -24.143 25.093  -19.078 1.00 9.56  ? 241 TYR B CB  1 
ATOM   3709 C CG  . TYR B 1 215 ? -25.433 25.899  -19.197 1.00 8.76  ? 241 TYR B CG  1 
ATOM   3710 C CD1 . TYR B 1 215 ? -26.382 25.907  -18.171 1.00 10.42 ? 241 TYR B CD1 1 
ATOM   3711 C CD2 . TYR B 1 215 ? -25.737 26.589  -20.371 1.00 9.82  ? 241 TYR B CD2 1 
ATOM   3712 C CE1 . TYR B 1 215 ? -27.568 26.606  -18.300 1.00 12.64 ? 241 TYR B CE1 1 
ATOM   3713 C CE2 . TYR B 1 215 ? -26.925 27.285  -20.508 1.00 10.45 ? 241 TYR B CE2 1 
ATOM   3714 C CZ  . TYR B 1 215 ? -27.834 27.300  -19.473 1.00 15.04 ? 241 TYR B CZ  1 
ATOM   3715 O OH  . TYR B 1 215 ? -29.021 27.995  -19.616 1.00 16.53 ? 241 TYR B OH  1 
ATOM   3716 N N   . GLY B 1 216 ? -23.197 21.545  -19.780 1.00 10.09 ? 242 GLY B N   1 
ATOM   3717 C CA  . GLY B 1 216 ? -22.019 20.725  -20.034 1.00 12.22 ? 242 GLY B CA  1 
ATOM   3718 C C   . GLY B 1 216 ? -20.876 21.012  -19.095 1.00 8.37  ? 242 GLY B C   1 
ATOM   3719 O O   . GLY B 1 216 ? -19.702 20.853  -19.469 1.00 8.08  ? 242 GLY B O   1 
ATOM   3720 N N   . THR B 1 217 ? -21.187 21.463  -17.883 1.00 8.96  ? 243 THR B N   1 
ATOM   3721 C CA  . THR B 1 217 ? -20.151 21.871  -16.948 1.00 7.86  ? 243 THR B CA  1 
ATOM   3722 C C   . THR B 1 217 ? -19.388 20.643  -16.475 1.00 7.13  ? 243 THR B C   1 
ATOM   3723 O O   . THR B 1 217 ? -19.985 19.649  -16.047 1.00 8.35  ? 243 THR B O   1 
ATOM   3724 C CB  . THR B 1 217 ? -20.767 22.653  -15.792 1.00 8.86  ? 243 THR B CB  1 
ATOM   3725 O OG1 . THR B 1 217 ? -21.346 23.850  -16.332 1.00 10.45 ? 243 THR B OG1 1 
ATOM   3726 C CG2 . THR B 1 217 ? -19.685 23.041  -14.760 1.00 9.55  ? 243 THR B CG2 1 
ATOM   3727 N N   . THR B 1 218 ? -18.065 20.701  -16.607 1.00 7.40  ? 244 THR B N   1 
ATOM   3728 C CA  . THR B 1 218 ? -17.192 19.551  -16.380 1.00 7.30  ? 244 THR B CA  1 
ATOM   3729 C C   . THR B 1 218 ? -15.980 20.071  -15.620 1.00 7.00  ? 244 THR B C   1 
ATOM   3730 O O   . THR B 1 218 ? -15.208 20.863  -16.165 1.00 8.04  ? 244 THR B O   1 
ATOM   3731 C CB  . THR B 1 218 ? -16.779 18.897  -17.710 1.00 8.55  ? 244 THR B CB  1 
ATOM   3732 O OG1 . THR B 1 218 ? -17.929 18.738  -18.565 1.00 9.28  ? 244 THR B OG1 1 
ATOM   3733 C CG2 . THR B 1 218 ? -16.153 17.544  -17.472 1.00 10.63 ? 244 THR B CG2 1 
ATOM   3734 N N   . ASN B 1 219 ? -15.823 19.654  -14.364 1.00 10.10 ? 245 ASN B N   1 
ATOM   3735 C CA  . ASN B 1 219 ? -14.837 20.240  -13.466 1.00 7.85  ? 245 ASN B CA  1 
ATOM   3736 C C   . ASN B 1 219 ? -13.988 19.168  -12.790 1.00 8.08  ? 245 ASN B C   1 
ATOM   3737 O O   . ASN B 1 219 ? -14.397 18.014  -12.639 1.00 7.61  ? 245 ASN B O   1 
ATOM   3738 C CB  . ASN B 1 219 ? -15.498 21.058  -12.360 1.00 6.79  ? 245 ASN B CB  1 
ATOM   3739 C CG  . ASN B 1 219 ? -16.328 22.216  -12.874 1.00 7.50  ? 245 ASN B CG  1 
ATOM   3740 O OD1 . ASN B 1 219 ? -16.077 22.785  -13.939 1.00 8.12  ? 245 ASN B OD1 1 
ATOM   3741 N ND2 . ASN B 1 219 ? -17.320 22.603  -12.083 1.00 9.34  ? 245 ASN B ND2 1 
ATOM   3742 N N   . ASP B 1 220 ? -12.816 19.581  -12.309 1.00 6.59  ? 246 ASP B N   1 
ATOM   3743 C CA  . ASP B 1 220 ? -11.972 18.694  -11.510 1.00 7.35  ? 246 ASP B CA  1 
ATOM   3744 C C   . ASP B 1 220 ? -11.007 19.565  -10.725 1.00 8.06  ? 246 ASP B C   1 
ATOM   3745 O O   . ASP B 1 220 ? -10.475 20.539  -11.265 1.00 9.21  ? 246 ASP B O   1 
ATOM   3746 C CB  . ASP B 1 220 ? -11.203 17.697  -12.390 1.00 6.62  ? 246 ASP B CB  1 
ATOM   3747 C CG  . ASP B 1 220 ? -10.720 16.476  -11.630 1.00 8.05  ? 246 ASP B CG  1 
ATOM   3748 O OD1 . ASP B 1 220 ? -11.161 16.241  -10.483 1.00 9.56  ? 246 ASP B OD1 1 
ATOM   3749 O OD2 . ASP B 1 220 ? -9.895  15.738  -12.192 1.00 9.44  ? 246 ASP B OD2 1 
ATOM   3750 N N   . ILE B 1 221 ? -10.816 19.249  -9.446  1.00 7.29  ? 247 ILE B N   1 
ATOM   3751 C CA  . ILE B 1 221 ? -9.811  19.923  -8.630  1.00 8.99  ? 247 ILE B CA  1 
ATOM   3752 C C   . ILE B 1 221 ? -8.940  18.858  -7.972  1.00 8.02  ? 247 ILE B C   1 
ATOM   3753 O O   . ILE B 1 221 ? -9.451  17.863  -7.450  1.00 8.97  ? 247 ILE B O   1 
ATOM   3754 C CB  . ILE B 1 221 ? -10.438 20.891  -7.596  1.00 9.30  ? 247 ILE B CB  1 
ATOM   3755 C CG1 . ILE B 1 221 ? -11.198 20.176  -6.466  1.00 7.68  ? 247 ILE B CG1 1 
ATOM   3756 C CG2 . ILE B 1 221 ? -11.353 21.910  -8.306  1.00 10.11 ? 247 ILE B CG2 1 
ATOM   3757 C CD1 . ILE B 1 221 ? -11.710 21.150  -5.371  1.00 10.43 ? 247 ILE B CD1 1 
ATOM   3758 N N   . ALA B 1 222 ? -7.628  19.040  -8.031  1.00 9.34  ? 248 ALA B N   1 
ATOM   3759 C CA  . ALA B 1 222 ? -6.741  17.942  -7.691  1.00 8.07  ? 248 ALA B CA  1 
ATOM   3760 C C   . ALA B 1 222 ? -5.514  18.407  -6.931  1.00 10.21 ? 248 ALA B C   1 
ATOM   3761 O O   . ALA B 1 222 ? -4.986  19.500  -7.155  1.00 9.70  ? 248 ALA B O   1 
ATOM   3762 C CB  . ALA B 1 222 ? -6.267  17.191  -8.948  1.00 8.68  ? 248 ALA B CB  1 
ATOM   3763 N N   A VAL B 1 223 ? -5.048  17.548  -6.032  0.54 8.35  ? 249 VAL B N   1 
ATOM   3764 N N   B VAL B 1 223 ? -5.077  17.556  -6.017  0.46 8.38  ? 249 VAL B N   1 
ATOM   3765 C CA  A VAL B 1 223 ? -3.720  17.663  -5.444  0.54 9.36  ? 249 VAL B CA  1 
ATOM   3766 C CA  B VAL B 1 223 ? -3.733  17.613  -5.465  0.46 9.36  ? 249 VAL B CA  1 
ATOM   3767 C C   A VAL B 1 223 ? -2.909  16.489  -5.974  0.54 11.44 ? 249 VAL B C   1 
ATOM   3768 C C   B VAL B 1 223 ? -2.955  16.496  -6.124  0.46 11.39 ? 249 VAL B C   1 
ATOM   3769 O O   A VAL B 1 223 ? -3.383  15.348  -5.962  0.54 11.13 ? 249 VAL B O   1 
ATOM   3770 O O   B VAL B 1 223 ? -3.479  15.394  -6.332  0.46 10.01 ? 249 VAL B O   1 
ATOM   3771 C CB  A VAL B 1 223 ? -3.774  17.711  -3.904  0.54 11.28 ? 249 VAL B CB  1 
ATOM   3772 C CB  B VAL B 1 223 ? -3.737  17.469  -3.935  0.46 10.78 ? 249 VAL B CB  1 
ATOM   3773 C CG1 A VAL B 1 223 ? -4.625  16.585  -3.323  0.54 10.46 ? 249 VAL B CG1 1 
ATOM   3774 C CG1 B VAL B 1 223 ? -2.338  17.672  -3.378  0.46 11.96 ? 249 VAL B CG1 1 
ATOM   3775 C CG2 A VAL B 1 223 ? -2.374  17.715  -3.307  0.54 11.91 ? 249 VAL B CG2 1 
ATOM   3776 C CG2 B VAL B 1 223 ? -4.680  18.469  -3.349  0.46 9.71  ? 249 VAL B CG2 1 
ATOM   3777 N N   . ILE B 1 224 ? -1.719  16.782  -6.498  1.00 11.80 ? 250 ILE B N   1 
ATOM   3778 C CA  . ILE B 1 224 ? -0.938  15.853  -7.304  1.00 13.66 ? 250 ILE B CA  1 
ATOM   3779 C C   . ILE B 1 224 ? 0.418   15.675  -6.652  1.00 14.59 ? 250 ILE B C   1 
ATOM   3780 O O   . ILE B 1 224 ? 1.061   16.657  -6.278  1.00 14.92 ? 250 ILE B O   1 
ATOM   3781 C CB  . ILE B 1 224 ? -0.772  16.365  -8.746  1.00 11.83 ? 250 ILE B CB  1 
ATOM   3782 C CG1 . ILE B 1 224 ? -2.124  16.570  -9.426  1.00 13.15 ? 250 ILE B CG1 1 
ATOM   3783 C CG2 . ILE B 1 224 ? 0.098   15.421  -9.560  1.00 16.80 ? 250 ILE B CG2 1 
ATOM   3784 C CD1 . ILE B 1 224 ? -2.099  17.621  -10.517 1.00 13.98 ? 250 ILE B CD1 1 
ATOM   3785 N N   . TRP B 1 225 ? 0.849   14.424  -6.511  1.00 13.98 ? 251 TRP B N   1 
ATOM   3786 C CA  . TRP B 1 225 ? 2.173   14.108  -5.990  1.00 15.95 ? 251 TRP B CA  1 
ATOM   3787 C C   . TRP B 1 225 ? 2.977   13.511  -7.135  1.00 15.97 ? 251 TRP B C   1 
ATOM   3788 O O   . TRP B 1 225 ? 2.947   12.290  -7.350  1.00 18.40 ? 251 TRP B O   1 
ATOM   3789 C CB  . TRP B 1 225 ? 2.080   13.142  -4.807  1.00 15.26 ? 251 TRP B CB  1 
ATOM   3790 C CG  . TRP B 1 225 ? 1.517   13.765  -3.573  1.00 16.21 ? 251 TRP B CG  1 
ATOM   3791 C CD1 . TRP B 1 225 ? 2.221   14.335  -2.550  1.00 18.39 ? 251 TRP B CD1 1 
ATOM   3792 C CD2 . TRP B 1 225 ? 0.131   13.880  -3.217  1.00 12.29 ? 251 TRP B CD2 1 
ATOM   3793 N NE1 . TRP B 1 225 ? 1.364   14.795  -1.583  1.00 23.25 ? 251 TRP B NE1 1 
ATOM   3794 C CE2 . TRP B 1 225 ? 0.075   14.534  -1.970  1.00 21.37 ? 251 TRP B CE2 1 
ATOM   3795 C CE3 . TRP B 1 225 ? -1.067  13.500  -3.835  1.00 18.73 ? 251 TRP B CE3 1 
ATOM   3796 C CZ2 . TRP B 1 225 ? -1.124  14.811  -1.324  1.00 19.60 ? 251 TRP B CZ2 1 
ATOM   3797 C CZ3 . TRP B 1 225 ? -2.267  13.779  -3.186  1.00 16.69 ? 251 TRP B CZ3 1 
ATOM   3798 C CH2 . TRP B 1 225 ? -2.283  14.426  -1.944  1.00 18.75 ? 251 TRP B CH2 1 
ATOM   3799 N N   . PRO B 1 226 ? 3.668   14.328  -7.925  1.00 17.06 ? 252 PRO B N   1 
ATOM   3800 C CA  . PRO B 1 226 ? 4.408   13.793  -9.067  1.00 19.41 ? 252 PRO B CA  1 
ATOM   3801 C C   . PRO B 1 226 ? 5.586   12.967  -8.596  1.00 17.59 ? 252 PRO B C   1 
ATOM   3802 O O   . PRO B 1 226 ? 6.117   13.164  -7.502  1.00 23.24 ? 252 PRO B O   1 
ATOM   3803 C CB  . PRO B 1 226 ? 4.879   15.046  -9.819  1.00 21.40 ? 252 PRO B CB  1 
ATOM   3804 C CG  . PRO B 1 226 ? 4.113   16.204  -9.207  1.00 18.58 ? 252 PRO B CG  1 
ATOM   3805 C CD  . PRO B 1 226 ? 3.823   15.788  -7.802  1.00 18.15 ? 252 PRO B CD  1 
ATOM   3806 N N   . GLN B 1 227 ? 5.977   12.016  -9.436  1.00 26.95 ? 254 GLN B N   1 
ATOM   3807 C CA  . GLN B 1 227 ? 7.194   11.262  -9.185  1.00 28.02 ? 254 GLN B CA  1 
ATOM   3808 C C   . GLN B 1 227 ? 8.383   12.208  -9.276  1.00 26.30 ? 254 GLN B C   1 
ATOM   3809 O O   . GLN B 1 227 ? 8.604   12.841  -10.315 1.00 26.07 ? 254 GLN B O   1 
ATOM   3810 C CB  . GLN B 1 227 ? 7.321   10.117  -10.187 1.00 35.35 ? 254 GLN B CB  1 
ATOM   3811 C CG  . GLN B 1 227 ? 8.747   9.698   -10.494 1.00 48.33 ? 254 GLN B CG  1 
ATOM   3812 C CD  . GLN B 1 227 ? 8.815   8.368   -11.222 1.00 57.24 ? 254 GLN B CD  1 
ATOM   3813 O OE1 . GLN B 1 227 ? 8.623   8.301   -12.438 1.00 61.71 ? 254 GLN B OE1 1 
ATOM   3814 N NE2 . GLN B 1 227 ? 9.079   7.299   -10.478 1.00 61.94 ? 254 GLN B NE2 1 
ATOM   3815 N N   . GLY B 1 228 ? 9.107   12.348  -8.171  1.00 29.50 ? 255 GLY B N   1 
ATOM   3816 C CA  . GLY B 1 228 ? 10.351  13.083  -8.156  1.00 30.38 ? 255 GLY B CA  1 
ATOM   3817 C C   . GLY B 1 228 ? 10.251  14.580  -7.970  1.00 30.94 ? 255 GLY B C   1 
ATOM   3818 O O   . GLY B 1 228 ? 11.263  15.270  -8.144  1.00 27.65 ? 255 GLY B O   1 
ATOM   3819 N N   A ARG B 1 229 ? 9.094   15.117  -7.603  0.46 28.89 ? 256 ARG B N   1 
ATOM   3820 N N   B ARG B 1 229 ? 9.064   15.098  -7.635  0.54 28.84 ? 256 ARG B N   1 
ATOM   3821 C CA  A ARG B 1 229 ? 9.038   16.552  -7.374  0.46 23.78 ? 256 ARG B CA  1 
ATOM   3822 C CA  B ARG B 1 229 ? 8.807   16.531  -7.532  0.54 24.65 ? 256 ARG B CA  1 
ATOM   3823 C C   A ARG B 1 229 ? 7.899   16.880  -6.422  0.46 20.64 ? 256 ARG B C   1 
ATOM   3824 C C   B ARG B 1 229 ? 7.972   16.828  -6.288  0.54 21.07 ? 256 ARG B C   1 
ATOM   3825 O O   A ARG B 1 229 ? 7.010   16.064  -6.169  0.46 19.19 ? 256 ARG B O   1 
ATOM   3826 O O   B ARG B 1 229 ? 7.357   15.936  -5.697  0.54 21.13 ? 256 ARG B O   1 
ATOM   3827 C CB  A ARG B 1 229 ? 8.899   17.321  -8.689  0.46 25.60 ? 256 ARG B CB  1 
ATOM   3828 C CB  B ARG B 1 229 ? 8.065   17.072  -8.768  0.54 23.15 ? 256 ARG B CB  1 
ATOM   3829 C CG  A ARG B 1 229 ? 7.510   17.294  -9.265  0.46 20.66 ? 256 ARG B CG  1 
ATOM   3830 C CG  B ARG B 1 229 ? 8.628   16.668  -10.129 0.54 20.18 ? 256 ARG B CG  1 
ATOM   3831 C CD  A ARG B 1 229 ? 7.477   17.910  -10.649 0.46 29.95 ? 256 ARG B CD  1 
ATOM   3832 C CD  B ARG B 1 229 ? 7.907   17.427  -11.241 0.54 26.66 ? 256 ARG B CD  1 
ATOM   3833 N NE  A ARG B 1 229 ? 7.517   19.366  -10.593 0.46 27.18 ? 256 ARG B NE  1 
ATOM   3834 N NE  B ARG B 1 229 ? 7.940   16.748  -12.532 0.54 21.87 ? 256 ARG B NE  1 
ATOM   3835 C CZ  A ARG B 1 229 ? 8.287   20.121  -11.362 0.46 26.03 ? 256 ARG B CZ  1 
ATOM   3836 C CZ  B ARG B 1 229 ? 8.458   17.272  -13.634 0.54 28.18 ? 256 ARG B CZ  1 
ATOM   3837 N NH1 A ARG B 1 229 ? 9.072   19.590  -12.287 0.46 27.65 ? 256 ARG B NH1 1 
ATOM   3838 N NH1 B ARG B 1 229 ? 9.040   18.460  -13.625 0.54 28.26 ? 256 ARG B NH1 1 
ATOM   3839 N NH2 A ARG B 1 229 ? 8.261   21.442  -11.209 0.46 33.51 ? 256 ARG B NH2 1 
ATOM   3840 N NH2 B ARG B 1 229 ? 8.391   16.589  -14.773 0.54 39.70 ? 256 ARG B NH2 1 
ATOM   3841 N N   . ALA B 1 230 ? 7.952   18.105  -5.895  1.00 21.52 ? 257 ALA B N   1 
ATOM   3842 C CA  . ALA B 1 230 ? 7.040   18.551  -4.853  1.00 18.30 ? 257 ALA B CA  1 
ATOM   3843 C C   . ALA B 1 230 ? 5.606   18.551  -5.380  1.00 11.85 ? 257 ALA B C   1 
ATOM   3844 O O   . ALA B 1 230 ? 5.382   18.609  -6.590  1.00 15.43 ? 257 ALA B O   1 
ATOM   3845 C CB  . ALA B 1 230 ? 7.426   19.951  -4.370  1.00 15.68 ? 257 ALA B CB  1 
ATOM   3846 N N   . PRO B 1 231 ? 4.618   18.480  -4.487  1.00 12.57 ? 258 PRO B N   1 
ATOM   3847 C CA  . PRO B 1 231 ? 3.223   18.386  -4.946  1.00 12.08 ? 258 PRO B CA  1 
ATOM   3848 C C   . PRO B 1 231 ? 2.756   19.616  -5.715  1.00 10.68 ? 258 PRO B C   1 
ATOM   3849 O O   . PRO B 1 231 ? 3.282   20.726  -5.571  1.00 12.69 ? 258 PRO B O   1 
ATOM   3850 C CB  . PRO B 1 231 ? 2.421   18.199  -3.650  1.00 15.25 ? 258 PRO B CB  1 
ATOM   3851 C CG  . PRO B 1 231 ? 3.368   18.428  -2.528  1.00 21.43 ? 258 PRO B CG  1 
ATOM   3852 C CD  . PRO B 1 231 ? 4.752   18.178  -3.054  1.00 13.69 ? 258 PRO B CD  1 
ATOM   3853 N N   . LEU B 1 232 ? 1.747   19.383  -6.560  1.00 12.67 ? 259 LEU B N   1 
ATOM   3854 C CA  . LEU B 1 232 ? 1.053   20.414  -7.321  1.00 11.17 ? 259 LEU B CA  1 
ATOM   3855 C C   . LEU B 1 232 ? -0.400  20.461  -6.886  1.00 11.35 ? 259 LEU B C   1 
ATOM   3856 O O   . LEU B 1 232 ? -0.953  19.458  -6.439  1.00 11.70 ? 259 LEU B O   1 
ATOM   3857 C CB  . LEU B 1 232 ? 1.084   20.137  -8.829  1.00 13.28 ? 259 LEU B CB  1 
ATOM   3858 C CG  . LEU B 1 232 ? 2.371   19.597  -9.452  1.00 13.39 ? 259 LEU B CG  1 
ATOM   3859 C CD1 . LEU B 1 232 ? 2.118   19.063  -10.848 1.00 14.35 ? 259 LEU B CD1 1 
ATOM   3860 C CD2 . LEU B 1 232 ? 3.415   20.701  -9.486  1.00 15.49 ? 259 LEU B CD2 1 
ATOM   3861 N N   . VAL B 1 233 ? -1.020  21.625  -7.038  1.00 8.21  ? 260 VAL B N   1 
ATOM   3862 C CA  . VAL B 1 233 ? -2.463  21.768  -6.934  1.00 6.55  ? 260 VAL B CA  1 
ATOM   3863 C C   . VAL B 1 233 ? -2.956  22.241  -8.289  1.00 9.45  ? 260 VAL B C   1 
ATOM   3864 O O   . VAL B 1 233 ? -2.388  23.179  -8.859  1.00 8.93  ? 260 VAL B O   1 
ATOM   3865 C CB  . VAL B 1 233 ? -2.861  22.747  -5.813  1.00 9.96  ? 260 VAL B CB  1 
ATOM   3866 C CG1 . VAL B 1 233 ? -4.373  22.927  -5.789  1.00 10.54 ? 260 VAL B CG1 1 
ATOM   3867 C CG2 . VAL B 1 233 ? -2.334  22.240  -4.475  1.00 12.07 ? 260 VAL B CG2 1 
ATOM   3868 N N   . LEU B 1 234 ? -3.988  21.586  -8.824  1.00 8.44  ? 261 LEU B N   1 
ATOM   3869 C CA  . LEU B 1 234 ? -4.468  21.936  -10.157 1.00 7.01  ? 261 LEU B CA  1 
ATOM   3870 C C   . LEU B 1 234 ? -5.986  21.962  -10.170 1.00 8.06  ? 261 LEU B C   1 
ATOM   3871 O O   . LEU B 1 234 ? -6.632  20.994  -9.753  1.00 8.66  ? 261 LEU B O   1 
ATOM   3872 C CB  . LEU B 1 234 ? -3.970  20.940  -11.210 1.00 7.41  ? 261 LEU B CB  1 
ATOM   3873 C CG  . LEU B 1 234 ? -4.502  21.188  -12.617 1.00 6.99  ? 261 LEU B CG  1 
ATOM   3874 C CD1 . LEU B 1 234 ? -4.076  22.550  -13.128 1.00 12.15 ? 261 LEU B CD1 1 
ATOM   3875 C CD2 . LEU B 1 234 ? -4.015  20.097  -13.550 1.00 9.39  ? 261 LEU B CD2 1 
ATOM   3876 N N   . VAL B 1 235 ? -6.551  23.064  -10.649 1.00 6.91  ? 262 VAL B N   1 
ATOM   3877 C CA  . VAL B 1 235 ? -7.990  23.212  -10.821 1.00 7.91  ? 262 VAL B CA  1 
ATOM   3878 C C   . VAL B 1 235 ? -8.267  23.372  -12.313 1.00 8.99  ? 262 VAL B C   1 
ATOM   3879 O O   . VAL B 1 235 ? -7.622  24.190  -12.983 1.00 8.89  ? 262 VAL B O   1 
ATOM   3880 C CB  . VAL B 1 235 ? -8.518  24.424  -10.027 1.00 10.36 ? 262 VAL B CB  1 
ATOM   3881 C CG1 . VAL B 1 235 ? -9.920  24.820  -10.493 1.00 17.70 ? 262 VAL B CG1 1 
ATOM   3882 C CG2 . VAL B 1 235 ? -8.437  24.153  -8.513  1.00 11.44 ? 262 VAL B CG2 1 
ATOM   3883 N N   . THR B 1 236 ? -9.214  22.595  -12.837 1.00 8.14  ? 263 THR B N   1 
ATOM   3884 C CA  . THR B 1 236 ? -9.640  22.724  -14.231 1.00 7.44  ? 263 THR B CA  1 
ATOM   3885 C C   . THR B 1 236 ? -11.154 22.806  -14.254 1.00 7.53  ? 263 THR B C   1 
ATOM   3886 O O   . THR B 1 236 ? -11.838 21.850  -13.867 1.00 9.85  ? 263 THR B O   1 
ATOM   3887 C CB  . THR B 1 236 ? -9.176  21.564  -15.112 1.00 7.87  ? 263 THR B CB  1 
ATOM   3888 O OG1 . THR B 1 236 ? -9.669  20.329  -14.581 1.00 9.42  ? 263 THR B OG1 1 
ATOM   3889 C CG2 . THR B 1 236 ? -7.657  21.501  -15.183 1.00 8.38  ? 263 THR B CG2 1 
ATOM   3890 N N   . TYR B 1 237 ? -11.673 23.936  -14.705 1.00 7.20  ? 264 TYR B N   1 
ATOM   3891 C CA  . TYR B 1 237 ? -13.103 24.184  -14.784 1.00 7.32  ? 264 TYR B CA  1 
ATOM   3892 C C   . TYR B 1 237 ? -13.479 24.402  -16.241 1.00 9.10  ? 264 TYR B C   1 
ATOM   3893 O O   . TYR B 1 237 ? -12.732 25.039  -16.992 1.00 9.46  ? 264 TYR B O   1 
ATOM   3894 C CB  . TYR B 1 237 ? -13.466 25.434  -13.966 1.00 8.39  ? 264 TYR B CB  1 
ATOM   3895 C CG  . TYR B 1 237 ? -13.563 25.214  -12.469 1.00 9.79  ? 264 TYR B CG  1 
ATOM   3896 C CD1 . TYR B 1 237 ? -13.624 23.929  -11.931 1.00 16.97 ? 264 TYR B CD1 1 
ATOM   3897 C CD2 . TYR B 1 237 ? -13.659 26.291  -11.598 1.00 17.82 ? 264 TYR B CD2 1 
ATOM   3898 C CE1 . TYR B 1 237 ? -13.752 23.727  -10.557 1.00 16.53 ? 264 TYR B CE1 1 
ATOM   3899 C CE2 . TYR B 1 237 ? -13.777 26.094  -10.223 1.00 17.66 ? 264 TYR B CE2 1 
ATOM   3900 C CZ  . TYR B 1 237 ? -13.828 24.810  -9.721  1.00 15.00 ? 264 TYR B CZ  1 
ATOM   3901 O OH  . TYR B 1 237 ? -13.956 24.600  -8.357  1.00 17.26 ? 264 TYR B OH  1 
ATOM   3902 N N   . PHE B 1 238 ? -14.645 23.906  -16.638 1.00 8.15  ? 265 PHE B N   1 
ATOM   3903 C CA  . PHE B 1 238 ? -15.059 23.991  -18.035 1.00 6.89  ? 265 PHE B CA  1 
ATOM   3904 C C   . PHE B 1 238 ? -16.576 24.067  -18.122 1.00 7.37  ? 265 PHE B C   1 
ATOM   3905 O O   . PHE B 1 238 ? -17.282 23.291  -17.468 1.00 8.89  ? 265 PHE B O   1 
ATOM   3906 C CB  . PHE B 1 238 ? -14.545 22.779  -18.819 1.00 6.42  ? 265 PHE B CB  1 
ATOM   3907 C CG  . PHE B 1 238 ? -14.858 22.831  -20.290 1.00 9.14  ? 265 PHE B CG  1 
ATOM   3908 C CD1 . PHE B 1 238 ? -14.206 23.730  -21.103 1.00 9.41  ? 265 PHE B CD1 1 
ATOM   3909 C CD2 . PHE B 1 238 ? -15.809 21.981  -20.858 1.00 8.38  ? 265 PHE B CD2 1 
ATOM   3910 C CE1 . PHE B 1 238 ? -14.482 23.784  -22.481 1.00 9.70  ? 265 PHE B CE1 1 
ATOM   3911 C CE2 . PHE B 1 238 ? -16.077 22.019  -22.224 1.00 8.66  ? 265 PHE B CE2 1 
ATOM   3912 C CZ  . PHE B 1 238 ? -15.420 22.939  -23.038 1.00 9.23  ? 265 PHE B CZ  1 
ATOM   3913 N N   . THR B 1 239 ? -17.086 24.989  -18.935 1.00 8.55  ? 266 THR B N   1 
ATOM   3914 C CA  . THR B 1 239 ? -18.531 25.121  -19.067 1.00 7.90  ? 266 THR B CA  1 
ATOM   3915 C C   . THR B 1 239 ? -18.845 25.570  -20.491 1.00 9.75  ? 266 THR B C   1 
ATOM   3916 O O   . THR B 1 239 ? -17.990 26.128  -21.178 1.00 10.15 ? 266 THR B O   1 
ATOM   3917 C CB  . THR B 1 239 ? -19.088 26.079  -17.991 1.00 7.68  ? 266 THR B CB  1 
ATOM   3918 O OG1 . THR B 1 239 ? -20.527 25.991  -17.933 1.00 12.17 ? 266 THR B OG1 1 
ATOM   3919 C CG2 . THR B 1 239 ? -18.641 27.516  -18.261 1.00 9.32  ? 266 THR B CG2 1 
ATOM   3920 N N   . GLN B 1 240 ? -20.064 25.301  -20.945 1.00 7.27  ? 267 GLN B N   1 
ATOM   3921 C CA  . GLN B 1 240 ? -20.404 25.391  -22.358 1.00 8.58  ? 267 GLN B CA  1 
ATOM   3922 C C   . GLN B 1 240 ? -21.658 26.230  -22.542 1.00 10.20 ? 267 GLN B C   1 
ATOM   3923 O O   . GLN B 1 240 ? -22.395 26.478  -21.582 1.00 10.15 ? 267 GLN B O   1 
ATOM   3924 C CB  . GLN B 1 240 ? -20.592 23.986  -22.956 1.00 8.88  ? 267 GLN B CB  1 
ATOM   3925 C CG  . GLN B 1 240 ? -19.320 23.134  -22.850 1.00 12.51 ? 267 GLN B CG  1 
ATOM   3926 C CD  . GLN B 1 240 ? -19.506 21.699  -23.330 1.00 11.69 ? 267 GLN B CD  1 
ATOM   3927 O OE1 . GLN B 1 240 ? -19.647 21.433  -24.531 1.00 13.08 ? 267 GLN B OE1 1 
ATOM   3928 N NE2 . GLN B 1 240 ? -19.542 20.770  -22.388 1.00 8.85  ? 267 GLN B NE2 1 
ATOM   3929 N N   . PRO B 1 241 ? -21.918 26.710  -23.768 1.00 10.24 ? 268 PRO B N   1 
ATOM   3930 C CA  . PRO B 1 241 ? -22.991 27.700  -23.952 1.00 11.20 ? 268 PRO B CA  1 
ATOM   3931 C C   . PRO B 1 241 ? -24.405 27.154  -23.928 1.00 12.00 ? 268 PRO B C   1 
ATOM   3932 O O   . PRO B 1 241 ? -25.320 27.945  -23.678 1.00 15.28 ? 268 PRO B O   1 
ATOM   3933 C CB  . PRO B 1 241 ? -22.689 28.314  -25.334 1.00 13.77 ? 268 PRO B CB  1 
ATOM   3934 C CG  . PRO B 1 241 ? -21.367 27.787  -25.753 1.00 14.12 ? 268 PRO B CG  1 
ATOM   3935 C CD  . PRO B 1 241 ? -21.128 26.521  -25.002 1.00 13.55 ? 268 PRO B CD  1 
ATOM   3936 N N   . GLN B 1 242 ? -24.624 25.864  -24.190 1.00 13.99 ? 269 GLN B N   1 
ATOM   3937 C CA  . GLN B 1 242 ? -25.971 25.305  -24.283 1.00 15.10 ? 269 GLN B CA  1 
ATOM   3938 C C   . GLN B 1 242 ? -26.289 24.461  -23.053 1.00 12.34 ? 269 GLN B C   1 
ATOM   3939 O O   . GLN B 1 242 ? -25.441 23.696  -22.569 1.00 11.52 ? 269 GLN B O   1 
ATOM   3940 C CB  . GLN B 1 242 ? -26.128 24.459  -25.550 1.00 22.37 ? 269 GLN B CB  1 
ATOM   3941 C CG  . GLN B 1 242 ? -26.039 25.257  -26.854 1.00 24.20 ? 269 GLN B CG  1 
ATOM   3942 C CD  . GLN B 1 242 ? -27.375 25.832  -27.297 1.00 31.04 ? 269 GLN B CD  1 
ATOM   3943 O OE1 . GLN B 1 242 ? -27.443 26.637  -28.231 1.00 29.27 ? 269 GLN B OE1 1 
ATOM   3944 N NE2 . GLN B 1 242 ? -28.446 25.424  -26.624 1.00 29.13 ? 269 GLN B NE2 1 
ATOM   3945 N N   . GLN B 1 243 ? -27.526 24.594  -22.562 1.00 12.76 ? 270 GLN B N   1 
ATOM   3946 C CA  . GLN B 1 243 ? -27.905 23.977  -21.291 1.00 9.99  ? 270 GLN B CA  1 
ATOM   3947 C C   . GLN B 1 243 ? -27.745 22.465  -21.309 1.00 10.97 ? 270 GLN B C   1 
ATOM   3948 O O   . GLN B 1 243 ? -27.422 21.868  -20.275 1.00 11.66 ? 270 GLN B O   1 
ATOM   3949 C CB  . GLN B 1 243 ? -29.355 24.316  -20.955 1.00 10.50 ? 270 GLN B CB  1 
ATOM   3950 C CG  . GLN B 1 243 ? -29.727 23.963  -19.533 1.00 11.98 ? 270 GLN B CG  1 
ATOM   3951 C CD  . GLN B 1 243 ? -31.151 24.331  -19.205 1.00 18.66 ? 270 GLN B CD  1 
ATOM   3952 O OE1 . GLN B 1 243 ? -31.433 24.879  -18.135 1.00 27.46 ? 270 GLN B OE1 1 
ATOM   3953 N NE2 . GLN B 1 243 ? -32.063 24.039  -20.124 1.00 24.82 ? 270 GLN B NE2 1 
ATOM   3954 N N   A ASN B 1 244 ? -27.990 21.822  -22.456 0.52 11.62 ? 271 ASN B N   1 
ATOM   3955 N N   B ASN B 1 244 ? -27.983 21.828  -22.455 0.48 11.63 ? 271 ASN B N   1 
ATOM   3956 C CA  A ASN B 1 244 ? -27.965 20.367  -22.548 0.52 13.16 ? 271 ASN B CA  1 
ATOM   3957 C CA  B ASN B 1 244 ? -27.955 20.376  -22.554 0.48 13.17 ? 271 ASN B CA  1 
ATOM   3958 C C   A ASN B 1 244 ? -26.645 19.830  -23.092 0.52 13.56 ? 271 ASN B C   1 
ATOM   3959 C C   B ASN B 1 244 ? -26.657 19.858  -23.155 0.48 13.51 ? 271 ASN B C   1 
ATOM   3960 O O   A ASN B 1 244 ? -26.591 18.675  -23.530 0.52 15.23 ? 271 ASN B O   1 
ATOM   3961 O O   B ASN B 1 244 ? -26.629 18.745  -23.692 0.48 15.38 ? 271 ASN B O   1 
ATOM   3962 C CB  A ASN B 1 244 ? -29.127 19.855  -23.408 0.52 16.32 ? 271 ASN B CB  1 
ATOM   3963 C CB  B ASN B 1 244 ? -29.154 19.887  -23.363 0.48 16.39 ? 271 ASN B CB  1 
ATOM   3964 C CG  A ASN B 1 244 ? -29.057 20.332  -24.851 0.52 23.61 ? 271 ASN B CG  1 
ATOM   3965 C CG  B ASN B 1 244 ? -30.457 20.144  -22.651 0.48 15.24 ? 271 ASN B CG  1 
ATOM   3966 O OD1 A ASN B 1 244 ? -28.218 21.154  -25.214 0.52 20.67 ? 271 ASN B OD1 1 
ATOM   3967 O OD1 B ASN B 1 244 ? -30.484 20.287  -21.429 0.48 23.59 ? 271 ASN B OD1 1 
ATOM   3968 N ND2 A ASN B 1 244 ? -29.954 19.815  -25.684 0.52 28.61 ? 271 ASN B ND2 1 
ATOM   3969 N ND2 B ASN B 1 244 ? -31.548 20.205  -23.406 0.48 25.67 ? 271 ASN B ND2 1 
ATOM   3970 N N   . ALA B 1 245 ? -25.582 20.634  -23.054 1.00 12.28 ? 272 ALA B N   1 
ATOM   3971 C CA  . ALA B 1 245 ? -24.292 20.213  -23.586 1.00 10.92 ? 272 ALA B CA  1 
ATOM   3972 C C   . ALA B 1 245 ? -23.782 18.963  -22.875 1.00 12.09 ? 272 ALA B C   1 
ATOM   3973 O O   . ALA B 1 245 ? -24.043 18.738  -21.691 1.00 13.64 ? 272 ALA B O   1 
ATOM   3974 C CB  . ALA B 1 245 ? -23.274 21.345  -23.454 1.00 11.62 ? 272 ALA B CB  1 
ATOM   3975 N N   A GLU B 1 246 ? -23.026 18.159  -23.615 0.54 15.48 ? 273 GLU B N   1 
ATOM   3976 N N   B GLU B 1 246 ? -23.069 18.130  -23.628 0.46 15.52 ? 273 GLU B N   1 
ATOM   3977 C CA  A GLU B 1 246 ? -22.463 16.930  -23.092 0.54 14.53 ? 273 GLU B CA  1 
ATOM   3978 C CA  B GLU B 1 246 ? -22.514 16.905  -23.082 0.46 14.49 ? 273 GLU B CA  1 
ATOM   3979 C C   A GLU B 1 246 ? -21.220 17.219  -22.255 0.54 11.64 ? 273 GLU B C   1 
ATOM   3980 C C   B GLU B 1 246 ? -21.252 17.208  -22.280 0.46 11.73 ? 273 GLU B C   1 
ATOM   3981 O O   A GLU B 1 246 ? -20.546 18.236  -22.428 0.54 14.36 ? 273 GLU B O   1 
ATOM   3982 O O   B GLU B 1 246 ? -20.571 18.211  -22.501 0.46 14.23 ? 273 GLU B O   1 
ATOM   3983 C CB  A GLU B 1 246 ? -22.104 15.985  -24.242 0.54 19.30 ? 273 GLU B CB  1 
ATOM   3984 C CB  B GLU B 1 246 ? -22.179 15.910  -24.198 0.46 19.39 ? 273 GLU B CB  1 
ATOM   3985 C CG  A GLU B 1 246 ? -20.843 16.392  -25.003 0.54 19.45 ? 273 GLU B CG  1 
ATOM   3986 C CG  B GLU B 1 246 ? -23.364 15.398  -25.006 0.46 25.67 ? 273 GLU B CG  1 
ATOM   3987 C CD  A GLU B 1 246 ? -21.114 17.346  -26.158 0.54 27.10 ? 273 GLU B CD  1 
ATOM   3988 C CD  B GLU B 1 246 ? -24.417 14.724  -24.153 0.46 24.06 ? 273 GLU B CD  1 
ATOM   3989 O OE1 A GLU B 1 246 ? -22.207 17.960  -26.198 0.54 26.78 ? 273 GLU B OE1 1 
ATOM   3990 O OE1 B GLU B 1 246 ? -24.050 14.007  -23.196 0.46 32.35 ? 273 GLU B OE1 1 
ATOM   3991 O OE2 A GLU B 1 246 ? -20.224 17.478  -27.032 0.54 25.11 ? 273 GLU B OE2 1 
ATOM   3992 O OE2 B GLU B 1 246 ? -25.617 14.892  -24.451 0.46 31.75 ? 273 GLU B OE2 1 
ATOM   3993 N N   A SER B 1 247 ? -20.920 16.295  -21.342 0.54 12.82 ? 274 SER B N   1 
ATOM   3994 N N   B SER B 1 247 ? -20.944 16.310  -21.347 0.46 12.84 ? 274 SER B N   1 
ATOM   3995 C CA  A SER B 1 247 ? -19.714 16.399  -20.532 0.54 11.75 ? 274 SER B CA  1 
ATOM   3996 C CA  B SER B 1 247 ? -19.723 16.430  -20.563 0.46 11.81 ? 274 SER B CA  1 
ATOM   3997 C C   A SER B 1 247 ? -18.470 16.260  -21.407 0.54 11.87 ? 274 SER B C   1 
ATOM   3998 C C   B SER B 1 247 ? -18.495 16.332  -21.461 0.46 11.86 ? 274 SER B C   1 
ATOM   3999 O O   A SER B 1 247 ? -18.457 15.522  -22.397 0.54 13.66 ? 274 SER B O   1 
ATOM   4000 O O   B SER B 1 247 ? -18.512 15.683  -22.511 0.46 13.92 ? 274 SER B O   1 
ATOM   4001 C CB  A SER B 1 247 ? -19.707 15.329  -19.439 0.54 13.40 ? 274 SER B CB  1 
ATOM   4002 C CB  B SER B 1 247 ? -19.672 15.342  -19.496 0.46 13.33 ? 274 SER B CB  1 
ATOM   4003 O OG  A SER B 1 247 ? -20.611 15.643  -18.385 0.54 12.79 ? 274 SER B OG  1 
ATOM   4004 O OG  B SER B 1 247 ? -19.616 14.062  -20.098 0.46 18.59 ? 274 SER B OG  1 
ATOM   4005 N N   . ARG B 1 248 ? -17.413 16.981  -21.034 1.00 11.55 ? 275 ARG B N   1 
ATOM   4006 C CA  . ARG B 1 248 ? -16.163 16.980  -21.789 1.00 8.54  ? 275 ARG B CA  1 
ATOM   4007 C C   . ARG B 1 248 ? -14.969 16.758  -20.861 1.00 9.98  ? 275 ARG B C   1 
ATOM   4008 O O   . ARG B 1 248 ? -14.102 17.606  -20.716 1.00 8.81  ? 275 ARG B O   1 
ATOM   4009 C CB  . ARG B 1 248 ? -15.994 18.285  -22.566 1.00 11.14 ? 275 ARG B CB  1 
ATOM   4010 C CG  . ARG B 1 248 ? -16.983 18.471  -23.729 1.00 10.04 ? 275 ARG B CG  1 
ATOM   4011 C CD  . ARG B 1 248 ? -16.813 17.416  -24.839 1.00 10.88 ? 275 ARG B CD  1 
ATOM   4012 N NE  . ARG B 1 248 ? -15.456 17.349  -25.369 1.00 11.70 ? 275 ARG B NE  1 
ATOM   4013 C CZ  . ARG B 1 248 ? -15.026 18.026  -26.425 1.00 12.84 ? 275 ARG B CZ  1 
ATOM   4014 N NH1 . ARG B 1 248 ? -15.815 18.868  -27.068 1.00 13.51 ? 275 ARG B NH1 1 
ATOM   4015 N NH2 . ARG B 1 248 ? -13.777 17.839  -26.853 1.00 15.06 ? 275 ARG B NH2 1 
ATOM   4016 N N   . ARG B 1 249 ? -14.915 15.588  -20.220 1.00 10.35 ? 276 ARG B N   1 
ATOM   4017 C CA  . ARG B 1 249 ? -13.796 15.314  -19.327 1.00 8.08  ? 276 ARG B CA  1 
ATOM   4018 C C   . ARG B 1 249 ? -12.483 15.270  -20.094 1.00 8.65  ? 276 ARG B C   1 
ATOM   4019 O O   . ARG B 1 249 ? -11.423 15.551  -19.528 1.00 9.20  ? 276 ARG B O   1 
ATOM   4020 C CB  . ARG B 1 249 ? -14.048 14.015  -18.564 1.00 11.91 ? 276 ARG B CB  1 
ATOM   4021 C CG  . ARG B 1 249 ? -15.183 14.152  -17.556 1.00 9.43  ? 276 ARG B CG  1 
ATOM   4022 C CD  . ARG B 1 249 ? -15.500 12.860  -16.839 1.00 13.04 ? 276 ARG B CD  1 
ATOM   4023 N NE  . ARG B 1 249 ? -15.935 11.824  -17.764 1.00 21.27 ? 276 ARG B NE  1 
ATOM   4024 C CZ  . ARG B 1 249 ? -16.464 10.663  -17.396 1.00 34.80 ? 276 ARG B CZ  1 
ATOM   4025 N NH1 . ARG B 1 249 ? -16.707 10.384  -16.121 1.00 20.13 ? 276 ARG B NH1 1 
ATOM   4026 N NH2 . ARG B 1 249 ? -16.738 9.753   -18.328 1.00 28.90 ? 276 ARG B NH2 1 
ATOM   4027 N N   . ASP B 1 250 ? -12.537 14.950  -21.389 1.00 10.14 ? 277 ASP B N   1 
ATOM   4028 C CA  . ASP B 1 250 ? -11.324 14.936  -22.196 1.00 9.07  ? 277 ASP B CA  1 
ATOM   4029 C C   . ASP B 1 250 ? -10.675 16.311  -22.273 1.00 10.63 ? 277 ASP B C   1 
ATOM   4030 O O   . ASP B 1 250 ? -9.454  16.399  -22.408 1.00 11.37 ? 277 ASP B O   1 
ATOM   4031 C CB  . ASP B 1 250 ? -11.643 14.432  -23.605 1.00 11.60 ? 277 ASP B CB  1 
ATOM   4032 C CG  . ASP B 1 250 ? -12.546 15.382  -24.359 1.00 19.31 ? 277 ASP B CG  1 
ATOM   4033 O OD1 . ASP B 1 250 ? -13.718 15.555  -23.943 1.00 12.86 ? 277 ASP B OD1 1 
ATOM   4034 O OD2 . ASP B 1 250 ? -12.068 15.981  -25.347 1.00 21.13 ? 277 ASP B OD2 1 
ATOM   4035 N N   . VAL B 1 251 ? -11.467 17.389  -22.207 1.00 9.11  ? 278 VAL B N   1 
ATOM   4036 C CA  . VAL B 1 251 ? -10.888 18.733  -22.213 1.00 9.11  ? 278 VAL B CA  1 
ATOM   4037 C C   . VAL B 1 251 ? -10.085 18.971  -20.943 1.00 8.94  ? 278 VAL B C   1 
ATOM   4038 O O   . VAL B 1 251 ? -9.006  19.576  -20.973 1.00 9.32  ? 278 VAL B O   1 
ATOM   4039 C CB  . VAL B 1 251 ? -11.999 19.792  -22.388 1.00 8.18  ? 278 VAL B CB  1 
ATOM   4040 C CG1 . VAL B 1 251 ? -11.444 21.221  -22.193 1.00 9.77  ? 278 VAL B CG1 1 
ATOM   4041 C CG2 . VAL B 1 251 ? -12.683 19.646  -23.754 1.00 11.86 ? 278 VAL B CG2 1 
ATOM   4042 N N   . LEU B 1 252 ? -10.572 18.462  -19.810 1.00 8.36  ? 279 LEU B N   1 
ATOM   4043 C CA  . LEU B 1 252 ? -9.813  18.596  -18.573 1.00 8.03  ? 279 LEU B CA  1 
ATOM   4044 C C   . LEU B 1 252 ? -8.526  17.795  -18.640 1.00 9.35  ? 279 LEU B C   1 
ATOM   4045 O O   . LEU B 1 252 ? -7.470  18.262  -18.198 1.00 9.75  ? 279 LEU B O   1 
ATOM   4046 C CB  . LEU B 1 252 ? -10.648 18.137  -17.377 1.00 7.10  ? 279 LEU B CB  1 
ATOM   4047 C CG  . LEU B 1 252 ? -12.040 18.764  -17.276 1.00 7.52  ? 279 LEU B CG  1 
ATOM   4048 C CD1 . LEU B 1 252 ? -12.700 18.324  -15.971 1.00 10.84 ? 279 LEU B CD1 1 
ATOM   4049 C CD2 . LEU B 1 252 ? -11.966 20.285  -17.345 1.00 8.30  ? 279 LEU B CD2 1 
ATOM   4050 N N   . ALA B 1 253 ? -8.607  16.569  -19.165 1.00 8.43  ? 280 ALA B N   1 
ATOM   4051 C CA  . ALA B 1 253 ? -7.394  15.780  -19.369 1.00 8.10  ? 280 ALA B CA  1 
ATOM   4052 C C   . ALA B 1 253 ? -6.398  16.511  -20.266 1.00 8.67  ? 280 ALA B C   1 
ATOM   4053 O O   . ALA B 1 253 ? -5.202  16.551  -19.965 1.00 9.61  ? 280 ALA B O   1 
ATOM   4054 C CB  . ALA B 1 253 ? -7.752  14.425  -19.971 1.00 9.72  ? 280 ALA B CB  1 
ATOM   4055 N N   . SER B 1 254 ? -6.887  17.126  -21.349 1.00 9.98  ? 281 SER B N   1 
ATOM   4056 C CA  . SER B 1 254 ? -6.001  17.854  -22.247 1.00 10.77 ? 281 SER B CA  1 
ATOM   4057 C C   . SER B 1 254 ? -5.348  19.040  -21.551 1.00 10.58 ? 281 SER B C   1 
ATOM   4058 O O   . SER B 1 254 ? -4.156  19.308  -21.759 1.00 10.54 ? 281 SER B O   1 
ATOM   4059 C CB  . SER B 1 254 ? -6.779  18.315  -23.476 1.00 8.18  ? 281 SER B CB  1 
ATOM   4060 O OG  . SER B 1 254 ? -7.090  17.204  -24.296 1.00 12.67 ? 281 SER B OG  1 
ATOM   4061 N N   . ALA B 1 255 ? -6.104  19.746  -20.707 1.00 8.03  ? 282 ALA B N   1 
ATOM   4062 C CA  . ALA B 1 255 ? -5.534  20.861  -19.963 1.00 8.10  ? 282 ALA B CA  1 
ATOM   4063 C C   . ALA B 1 255 ? -4.448  20.381  -19.012 1.00 10.08 ? 282 ALA B C   1 
ATOM   4064 O O   . ALA B 1 255 ? -3.385  21.004  -18.896 1.00 9.82  ? 282 ALA B O   1 
ATOM   4065 C CB  . ALA B 1 255 ? -6.636  21.582  -19.186 1.00 9.61  ? 282 ALA B CB  1 
ATOM   4066 N N   . ALA B 1 256 ? -4.715  19.283  -18.300 1.00 8.85  ? 283 ALA B N   1 
ATOM   4067 C CA  . ALA B 1 256 ? -3.726  18.752  -17.372 1.00 9.67  ? 283 ALA B CA  1 
ATOM   4068 C C   . ALA B 1 256 ? -2.465  18.325  -18.107 1.00 12.10 ? 283 ALA B C   1 
ATOM   4069 O O   . ALA B 1 256 ? -1.351  18.534  -17.611 1.00 9.88  ? 283 ALA B O   1 
ATOM   4070 C CB  . ALA B 1 256 ? -4.316  17.578  -16.594 1.00 11.77 ? 283 ALA B CB  1 
ATOM   4071 N N   . ARG B 1 257 ? -2.620  17.748  -19.305 1.00 9.83  ? 284 ARG B N   1 
ATOM   4072 C CA  . ARG B 1 257 ? -1.458  17.315  -20.073 1.00 10.81 ? 284 ARG B CA  1 
ATOM   4073 C C   . ARG B 1 257 ? -0.615  18.510  -20.508 1.00 13.44 ? 284 ARG B C   1 
ATOM   4074 O O   . ARG B 1 257 ? 0.615   18.452  -20.456 1.00 12.81 ? 284 ARG B O   1 
ATOM   4075 C CB  . ARG B 1 257 ? -1.898  16.472  -21.271 1.00 11.31 ? 284 ARG B CB  1 
ATOM   4076 C CG  . ARG B 1 257 ? -0.819  16.239  -22.313 1.00 18.77 ? 284 ARG B CG  1 
ATOM   4077 C CD  . ARG B 1 257 ? -1.195  15.150  -23.309 1.00 17.87 ? 284 ARG B CD  1 
ATOM   4078 N NE  . ARG B 1 257 ? -1.545  13.888  -22.665 1.00 31.76 ? 284 ARG B NE  1 
ATOM   4079 C CZ  . ARG B 1 257 ? -2.782  13.445  -22.473 1.00 47.75 ? 284 ARG B CZ  1 
ATOM   4080 N NH1 . ARG B 1 257 ? -3.837  14.128  -22.891 1.00 41.01 ? 284 ARG B NH1 1 
ATOM   4081 N NH2 . ARG B 1 257 ? -2.963  12.282  -21.851 1.00 47.16 ? 284 ARG B NH2 1 
ATOM   4082 N N   . ILE B 1 258 ? -1.257  19.603  -20.923 1.00 8.96  ? 285 ILE B N   1 
ATOM   4083 C CA  . ILE B 1 258 ? -0.521  20.821  -21.266 1.00 10.61 ? 285 ILE B CA  1 
ATOM   4084 C C   . ILE B 1 258 ? 0.235   21.344  -20.051 1.00 13.95 ? 285 ILE B C   1 
ATOM   4085 O O   . ILE B 1 258 ? 1.417   21.708  -20.140 1.00 12.50 ? 285 ILE B O   1 
ATOM   4086 C CB  . ILE B 1 258 ? -1.484  21.880  -21.831 1.00 9.94  ? 285 ILE B CB  1 
ATOM   4087 C CG1 . ILE B 1 258 ? -1.924  21.504  -23.254 1.00 8.89  ? 285 ILE B CG1 1 
ATOM   4088 C CG2 . ILE B 1 258 ? -0.852  23.287  -21.791 1.00 12.31 ? 285 ILE B CG2 1 
ATOM   4089 C CD1 . ILE B 1 258 ? -3.209  22.200  -23.690 1.00 10.64 ? 285 ILE B CD1 1 
ATOM   4090 N N   . ILE B 1 259 ? -0.438  21.382  -18.893 1.00 9.54  ? 286 ILE B N   1 
ATOM   4091 C CA  . ILE B 1 259 ? 0.210   21.839  -17.664 1.00 9.83  ? 286 ILE B CA  1 
ATOM   4092 C C   . ILE B 1 259 ? 1.428   20.978  -17.337 1.00 15.70 ? 286 ILE B C   1 
ATOM   4093 O O   . ILE B 1 259 ? 2.495   21.501  -16.992 1.00 16.50 ? 286 ILE B O   1 
ATOM   4094 C CB  . ILE B 1 259 ? -0.804  21.866  -16.504 1.00 13.66 ? 286 ILE B CB  1 
ATOM   4095 C CG1 . ILE B 1 259 ? -1.812  22.997  -16.723 1.00 12.35 ? 286 ILE B CG1 1 
ATOM   4096 C CG2 . ILE B 1 259 ? -0.092  21.967  -15.159 1.00 18.08 ? 286 ILE B CG2 1 
ATOM   4097 C CD1 . ILE B 1 259 ? -1.285  24.380  -16.464 1.00 14.13 ? 286 ILE B CD1 1 
ATOM   4098 N N   . ALA B 1 260 ? 1.298   19.647  -17.445 1.00 12.98 ? 287 ALA B N   1 
ATOM   4099 C CA  . ALA B 1 260 ? 2.415   18.766  -17.095 1.00 12.99 ? 287 ALA B CA  1 
ATOM   4100 C C   . ALA B 1 260 ? 3.573   18.906  -18.071 1.00 18.18 ? 287 ALA B C   1 
ATOM   4101 O O   . ALA B 1 260 ? 4.742   18.821  -17.672 1.00 17.24 ? 287 ALA B O   1 
ATOM   4102 C CB  . ALA B 1 260 ? 1.954   17.315  -17.058 1.00 13.86 ? 287 ALA B CB  1 
ATOM   4103 N N   A GLU B 1 261 ? 3.269   19.106  -19.354 0.49 15.64 ? 288 GLU B N   1 
ATOM   4104 N N   B GLU B 1 261 ? 3.269   19.087  -19.359 0.51 15.63 ? 288 GLU B N   1 
ATOM   4105 C CA  A GLU B 1 261 ? 4.312   19.270  -20.357 0.49 17.37 ? 288 GLU B CA  1 
ATOM   4106 C CA  B GLU B 1 261 ? 4.321   19.290  -20.350 0.51 17.38 ? 288 GLU B CA  1 
ATOM   4107 C C   A GLU B 1 261 ? 4.988   20.635  -20.279 0.49 18.63 ? 288 GLU B C   1 
ATOM   4108 C C   B GLU B 1 261 ? 5.109   20.561  -20.067 0.51 18.55 ? 288 GLU B C   1 
ATOM   4109 O O   A GLU B 1 261 ? 6.005   20.840  -20.950 0.49 22.56 ? 288 GLU B O   1 
ATOM   4110 O O   B GLU B 1 261 ? 6.308   20.635  -20.368 0.51 17.50 ? 288 GLU B O   1 
ATOM   4111 C CB  A GLU B 1 261 ? 3.728   19.029  -21.756 0.49 16.33 ? 288 GLU B CB  1 
ATOM   4112 C CB  B GLU B 1 261 ? 3.712   19.333  -21.758 0.51 17.50 ? 288 GLU B CB  1 
ATOM   4113 C CG  A GLU B 1 261 ? 3.710   17.557  -22.155 0.49 18.32 ? 288 GLU B CG  1 
ATOM   4114 C CG  B GLU B 1 261 ? 4.176   20.506  -22.629 0.51 27.57 ? 288 GLU B CG  1 
ATOM   4115 C CD  A GLU B 1 261 ? 2.648   17.207  -23.190 0.49 17.56 ? 288 GLU B CD  1 
ATOM   4116 C CD  B GLU B 1 261 ? 3.019   21.338  -23.178 0.51 26.26 ? 288 GLU B CD  1 
ATOM   4117 O OE1 A GLU B 1 261 ? 2.013   18.124  -23.758 0.49 17.57 ? 288 GLU B OE1 1 
ATOM   4118 O OE1 B GLU B 1 261 ? 2.421   20.913  -24.204 0.51 15.41 ? 288 GLU B OE1 1 
ATOM   4119 O OE2 A GLU B 1 261 ? 2.454   15.998  -23.437 0.49 22.33 ? 288 GLU B OE2 1 
ATOM   4120 O OE2 B GLU B 1 261 ? 2.728   22.415  -22.587 0.51 10.72 ? 288 GLU B OE2 1 
ATOM   4121 N N   . GLY B 1 262 ? 4.463   21.557  -19.473 1.00 17.56 ? 289 GLY B N   1 
ATOM   4122 C CA  . GLY B 1 262 ? 5.069   22.847  -19.229 1.00 18.52 ? 289 GLY B CA  1 
ATOM   4123 C C   . GLY B 1 262 ? 5.876   22.960  -17.958 1.00 23.93 ? 289 GLY B C   1 
ATOM   4124 O O   . GLY B 1 262 ? 6.425   24.033  -17.687 1.00 28.38 ? 289 GLY B O   1 
ATOM   4125 N N   . LEU B 1 263 ? 5.955   21.896  -17.163 1.00 22.14 ? 290 LEU B N   1 
ATOM   4126 C CA  . LEU B 1 263 ? 6.704   21.910  -15.907 1.00 24.67 ? 290 LEU B CA  1 
ATOM   4127 C C   . LEU B 1 263 ? 8.204   21.875  -16.168 1.00 39.27 ? 290 LEU B C   1 
ATOM   4128 O O   . LEU B 1 263 ? 8.659   21.134  -17.037 1.00 34.06 ? 290 LEU B O   1 
ATOM   4129 C CB  . LEU B 1 263 ? 6.311   20.720  -15.032 1.00 27.83 ? 290 LEU B CB  1 
ATOM   4130 C CG  . LEU B 1 263 ? 4.902   20.711  -14.446 1.00 27.12 ? 290 LEU B CG  1 
ATOM   4131 C CD1 . LEU B 1 263 ? 4.663   19.418  -13.680 1.00 23.48 ? 290 LEU B CD1 1 
ATOM   4132 C CD2 . LEU B 1 263 ? 4.676   21.921  -13.555 1.00 26.67 ? 290 LEU B CD2 1 
ATOM   4133 O OXT . LEU B 1 263 ? 8.985   22.568  -15.513 1.00 45.28 ? 290 LEU B OXT 1 
HETATM 4134 P P   . PO4 C 2 .   ? -4.261  -0.130  -14.831 1.00 18.32 ? 301 PO4 A P   1 
HETATM 4135 O O1  . PO4 C 2 .   ? -3.281  0.675   -15.657 1.00 24.39 ? 301 PO4 A O1  1 
HETATM 4136 O O2  . PO4 C 2 .   ? -5.522  -0.343  -15.638 1.00 19.16 ? 301 PO4 A O2  1 
HETATM 4137 O O3  . PO4 C 2 .   ? -3.595  -1.425  -14.379 1.00 19.32 ? 301 PO4 A O3  1 
HETATM 4138 O O4  . PO4 C 2 .   ? -4.626  0.698   -13.620 1.00 28.81 ? 301 PO4 A O4  1 
HETATM 4139 P P   . PO4 D 2 .   ? -27.950 -14.755 -3.478  1.00 29.80 ? 302 PO4 A P   1 
HETATM 4140 O O1  . PO4 D 2 .   ? -27.058 -13.566 -3.762  1.00 40.30 ? 302 PO4 A O1  1 
HETATM 4141 O O2  . PO4 D 2 .   ? -29.412 -14.361 -3.556  1.00 27.47 ? 302 PO4 A O2  1 
HETATM 4142 O O3  . PO4 D 2 .   ? -27.658 -15.840 -4.489  1.00 30.02 ? 302 PO4 A O3  1 
HETATM 4143 O O4  . PO4 D 2 .   ? -27.676 -15.275 -2.084  1.00 34.63 ? 302 PO4 A O4  1 
HETATM 4144 K K   . K   E 3 .   ? 0.817   0.527   -22.473 1.00 24.71 ? 303 K   A K   1 
HETATM 4145 P P   . PO4 F 2 .   ? -19.613 14.229  -10.727 1.00 22.06 ? 301 PO4 B P   1 
HETATM 4146 O O1  . PO4 F 2 .   ? -18.359 14.910  -11.239 1.00 20.53 ? 301 PO4 B O1  1 
HETATM 4147 O O2  . PO4 F 2 .   ? -20.574 14.035  -11.881 1.00 26.92 ? 301 PO4 B O2  1 
HETATM 4148 O O3  . PO4 F 2 .   ? -19.232 12.856  -10.194 1.00 30.29 ? 301 PO4 B O3  1 
HETATM 4149 O O4  . PO4 F 2 .   ? -20.343 15.031  -9.645  1.00 22.43 ? 301 PO4 B O4  1 
HETATM 4150 P P   . PO4 G 2 .   ? -27.693 38.528  -7.978  1.00 43.15 ? 302 PO4 B P   1 
HETATM 4151 O O1  . PO4 G 2 .   ? -26.609 39.584  -8.024  1.00 44.86 ? 302 PO4 B O1  1 
HETATM 4152 O O2  . PO4 G 2 .   ? -29.050 39.193  -8.075  1.00 46.71 ? 302 PO4 B O2  1 
HETATM 4153 O O3  . PO4 G 2 .   ? -27.494 37.572  -9.134  1.00 26.84 ? 302 PO4 B O3  1 
HETATM 4154 O O4  . PO4 G 2 .   ? -27.620 37.752  -6.682  1.00 36.02 ? 302 PO4 B O4  1 
HETATM 4155 P P   . PO4 H 2 .   ? -23.749 -2.307  0.973   1.00 66.60 ? 303 PO4 B P   1 
HETATM 4156 O O1  . PO4 H 2 .   ? -22.544 -2.882  1.682   1.00 51.24 ? 303 PO4 B O1  1 
HETATM 4157 O O2  . PO4 H 2 .   ? -23.339 -1.801  -0.392  1.00 33.34 ? 303 PO4 B O2  1 
HETATM 4158 O O3  . PO4 H 2 .   ? -24.805 -3.375  0.800   1.00 44.18 ? 303 PO4 B O3  1 
HETATM 4159 O O4  . PO4 H 2 .   ? -24.316 -1.165  1.789   1.00 54.35 ? 303 PO4 B O4  1 
HETATM 4160 K K   . K   I 3 .   ? -24.508 17.726  -17.710 1.00 23.03 ? 304 K   B K   1 
HETATM 4161 O O   . HOH J 4 .   ? 3.855   2.684   -32.150 1.00 41.32 ? 401 HOH A O   1 
HETATM 4162 O O   . HOH J 4 .   ? -14.937 -28.893 -18.588 1.00 26.17 ? 402 HOH A O   1 
HETATM 4163 O O   . HOH J 4 .   ? -3.834  2.530   -12.504 1.00 31.02 ? 403 HOH A O   1 
HETATM 4164 O O   . HOH J 4 .   ? -26.323 -15.585 -0.238  1.00 25.76 ? 404 HOH A O   1 
HETATM 4165 O O   . HOH J 4 .   ? -15.986 -19.136 14.086  1.00 31.97 ? 405 HOH A O   1 
HETATM 4166 O O   . HOH J 4 .   ? -32.892 -3.925  -19.814 1.00 42.01 ? 406 HOH A O   1 
HETATM 4167 O O   . HOH J 4 .   ? -23.465 -18.901 -13.480 1.00 42.34 ? 407 HOH A O   1 
HETATM 4168 O O   . HOH J 4 .   ? -9.885  -28.651 -13.155 1.00 31.61 ? 408 HOH A O   1 
HETATM 4169 O O   . HOH J 4 .   ? -23.987 -17.574 -10.753 1.00 32.04 ? 409 HOH A O   1 
HETATM 4170 O O   . HOH J 4 .   ? -15.414 -26.030 -17.780 1.00 24.18 ? 410 HOH A O   1 
HETATM 4171 O O   . HOH J 4 .   ? -22.761 5.429   -10.732 1.00 24.58 ? 411 HOH A O   1 
HETATM 4172 O O   A HOH J 4 .   ? -35.995 -13.311 -16.752 0.62 15.65 ? 412 HOH A O   1 
HETATM 4173 O O   B HOH J 4 .   ? -36.330 -13.495 -15.105 0.38 14.01 ? 412 HOH A O   1 
HETATM 4174 O O   . HOH J 4 .   ? -1.972  -8.142  -12.200 1.00 15.72 ? 413 HOH A O   1 
HETATM 4175 O O   . HOH J 4 .   ? -3.673  3.811   -9.456  1.00 23.89 ? 414 HOH A O   1 
HETATM 4176 O O   . HOH J 4 .   ? -32.468 -7.828  -20.559 1.00 47.47 ? 415 HOH A O   1 
HETATM 4177 O O   . HOH J 4 .   ? -0.609  -5.459  -14.338 1.00 20.97 ? 416 HOH A O   1 
HETATM 4178 O O   . HOH J 4 .   ? -29.692 -8.413  -22.645 1.00 38.19 ? 417 HOH A O   1 
HETATM 4179 O O   . HOH J 4 .   ? -16.304 -18.424 -30.569 1.00 21.22 ? 418 HOH A O   1 
HETATM 4180 O O   . HOH J 4 .   ? -9.065  -11.827 -12.733 1.00 24.39 ? 419 HOH A O   1 
HETATM 4181 O O   . HOH J 4 .   ? 11.512  -5.966  -7.248  1.00 21.76 ? 420 HOH A O   1 
HETATM 4182 O O   . HOH J 4 .   ? -21.934 -20.159 -8.191  1.00 23.11 ? 421 HOH A O   1 
HETATM 4183 O O   . HOH J 4 .   ? -26.857 -17.534 -22.992 1.00 25.13 ? 422 HOH A O   1 
HETATM 4184 O O   . HOH J 4 .   ? -12.759 -14.082 9.697   1.00 25.10 ? 423 HOH A O   1 
HETATM 4185 O O   . HOH J 4 .   ? -23.315 -9.731  -4.801  1.00 28.89 ? 424 HOH A O   1 
HETATM 4186 O O   . HOH J 4 .   ? -14.239 -27.189 -7.087  1.00 19.70 ? 425 HOH A O   1 
HETATM 4187 O O   . HOH J 4 .   ? -1.108  -8.281  -27.814 1.00 14.92 ? 426 HOH A O   1 
HETATM 4188 O O   . HOH J 4 .   ? -26.869 -16.229 -6.943  1.00 27.61 ? 427 HOH A O   1 
HETATM 4189 O O   . HOH J 4 .   ? -21.121 -17.477 -19.182 1.00 23.13 ? 428 HOH A O   1 
HETATM 4190 O O   . HOH J 4 .   ? -2.883  2.827   -17.081 1.00 30.49 ? 429 HOH A O   1 
HETATM 4191 O O   A HOH J 4 .   ? -6.883  -23.674 -20.426 0.56 16.96 ? 430 HOH A O   1 
HETATM 4192 O O   B HOH J 4 .   ? -7.291  -24.272 -22.297 0.44 19.45 ? 430 HOH A O   1 
HETATM 4193 O O   . HOH J 4 .   ? -21.287 -14.560 6.218   1.00 22.87 ? 431 HOH A O   1 
HETATM 4194 O O   . HOH J 4 .   ? -3.160  -0.060  8.710   1.00 36.14 ? 432 HOH A O   1 
HETATM 4195 O O   . HOH J 4 .   ? 3.673   -15.476 -29.959 1.00 30.38 ? 433 HOH A O   1 
HETATM 4196 O O   . HOH J 4 .   ? 8.813   -11.506 -9.397  1.00 23.28 ? 434 HOH A O   1 
HETATM 4197 O O   . HOH J 4 .   ? 5.390   4.044   -11.585 1.00 38.38 ? 435 HOH A O   1 
HETATM 4198 O O   . HOH J 4 .   ? -2.903  -6.967  11.660  1.00 25.28 ? 436 HOH A O   1 
HETATM 4199 O O   . HOH J 4 .   ? -4.327  -1.817  -37.445 1.00 29.54 ? 437 HOH A O   1 
HETATM 4200 O O   . HOH J 4 .   ? 1.213   -0.336  7.591   1.00 26.92 ? 438 HOH A O   1 
HETATM 4201 O O   . HOH J 4 .   ? -10.875 -16.134 -16.762 1.00 11.05 ? 439 HOH A O   1 
HETATM 4202 O O   . HOH J 4 .   ? -4.043  -2.757  9.793   1.00 35.78 ? 440 HOH A O   1 
HETATM 4203 O O   . HOH J 4 .   ? -17.005 -18.298 9.385   1.00 18.99 ? 441 HOH A O   1 
HETATM 4204 O O   . HOH J 4 .   ? 1.187   -10.632 -21.054 1.00 16.77 ? 442 HOH A O   1 
HETATM 4205 O O   . HOH J 4 .   ? 7.494   -7.596  -5.794  1.00 16.56 ? 443 HOH A O   1 
HETATM 4206 O O   . HOH J 4 .   ? -27.974 -11.562 -26.695 1.00 38.84 ? 444 HOH A O   1 
HETATM 4207 O O   . HOH J 4 .   ? -7.906  0.911   -0.818  1.00 21.06 ? 445 HOH A O   1 
HETATM 4208 O O   . HOH J 4 .   ? -6.295  -5.438  7.762   1.00 18.50 ? 446 HOH A O   1 
HETATM 4209 O O   . HOH J 4 .   ? -7.951  -28.958 -15.606 1.00 36.34 ? 447 HOH A O   1 
HETATM 4210 O O   . HOH J 4 .   ? 4.212   -20.974 -17.270 1.00 26.66 ? 448 HOH A O   1 
HETATM 4211 O O   . HOH J 4 .   ? -8.506  -1.290  -39.112 1.00 30.09 ? 449 HOH A O   1 
HETATM 4212 O O   . HOH J 4 .   ? -1.830  0.408   -22.844 1.00 19.99 ? 450 HOH A O   1 
HETATM 4213 O O   . HOH J 4 .   ? 6.092   -6.509  -24.528 1.00 13.67 ? 451 HOH A O   1 
HETATM 4214 O O   . HOH J 4 .   ? -12.943 -15.448 -32.696 1.00 15.63 ? 452 HOH A O   1 
HETATM 4215 O O   . HOH J 4 .   ? -21.740 7.866   -19.594 1.00 33.69 ? 453 HOH A O   1 
HETATM 4216 O O   . HOH J 4 .   ? -24.896 4.399   -22.333 1.00 24.46 ? 454 HOH A O   1 
HETATM 4217 O O   . HOH J 4 .   ? 0.706   -4.738  8.797   1.00 17.56 ? 455 HOH A O   1 
HETATM 4218 O O   A HOH J 4 .   ? -5.558  5.493   -8.678  0.51 17.48 ? 456 HOH A O   1 
HETATM 4219 O O   B HOH J 4 .   ? -8.425  8.268   -6.785  0.49 9.20  ? 456 HOH A O   1 
HETATM 4220 O O   . HOH J 4 .   ? -5.477  -4.755  -36.450 1.00 31.14 ? 457 HOH A O   1 
HETATM 4221 O O   . HOH J 4 .   ? -12.891 7.288   -22.109 1.00 20.69 ? 458 HOH A O   1 
HETATM 4222 O O   . HOH J 4 .   ? -6.580  -1.286  7.444   1.00 30.46 ? 459 HOH A O   1 
HETATM 4223 O O   . HOH J 4 .   ? 1.830   -7.082  -33.910 1.00 26.39 ? 460 HOH A O   1 
HETATM 4224 O O   . HOH J 4 .   ? -20.877 7.134   -16.754 1.00 25.68 ? 461 HOH A O   1 
HETATM 4225 O O   . HOH J 4 .   ? -23.644 -17.477 -16.744 1.00 23.20 ? 462 HOH A O   1 
HETATM 4226 O O   . HOH J 4 .   ? -2.777  -21.171 2.813   1.00 17.37 ? 463 HOH A O   1 
HETATM 4227 O O   . HOH J 4 .   ? -7.948  -0.777  -10.437 1.00 17.73 ? 464 HOH A O   1 
HETATM 4228 O O   . HOH J 4 .   ? 0.535   -16.472 5.208   1.00 30.20 ? 465 HOH A O   1 
HETATM 4229 O O   . HOH J 4 .   ? -13.908 -8.739  4.920   1.00 25.07 ? 466 HOH A O   1 
HETATM 4230 O O   . HOH J 4 .   ? -1.223  -20.463 0.404   1.00 21.37 ? 467 HOH A O   1 
HETATM 4231 O O   . HOH J 4 .   ? 7.781   -10.299 -13.363 1.00 12.80 ? 468 HOH A O   1 
HETATM 4232 O O   . HOH J 4 .   ? -19.503 1.086   -33.907 1.00 24.53 ? 469 HOH A O   1 
HETATM 4233 O O   . HOH J 4 .   ? 1.955   -0.118  -25.144 1.00 14.48 ? 470 HOH A O   1 
HETATM 4234 O O   . HOH J 4 .   ? -10.726 4.255   -16.559 1.00 10.23 ? 471 HOH A O   1 
HETATM 4235 O O   . HOH J 4 .   ? -25.187 -3.119  -5.750  1.00 34.32 ? 472 HOH A O   1 
HETATM 4236 O O   . HOH J 4 .   ? 0.660   -12.607 -22.738 1.00 14.05 ? 473 HOH A O   1 
HETATM 4237 O O   B HOH J 4 .   ? -12.223 -26.404 -13.335 0.92 23.93 ? 474 HOH A O   1 
HETATM 4238 O O   . HOH J 4 .   ? 9.118   -8.830  -10.120 1.00 18.28 ? 475 HOH A O   1 
HETATM 4239 O O   . HOH J 4 .   ? 3.252   -12.079 -23.399 1.00 11.67 ? 476 HOH A O   1 
HETATM 4240 O O   . HOH J 4 .   ? -2.422  -3.441  -15.768 1.00 15.14 ? 477 HOH A O   1 
HETATM 4241 O O   . HOH J 4 .   ? -7.577  -26.451 -8.177  1.00 16.85 ? 478 HOH A O   1 
HETATM 4242 O O   . HOH J 4 .   ? 9.756   -15.066 -20.607 1.00 26.89 ? 479 HOH A O   1 
HETATM 4243 O O   . HOH J 4 .   ? -2.674  -10.384 -28.541 1.00 16.17 ? 480 HOH A O   1 
HETATM 4244 O O   . HOH J 4 .   ? -0.722  -2.528  8.311   1.00 21.23 ? 481 HOH A O   1 
HETATM 4245 O O   . HOH J 4 .   ? -33.828 -16.932 -19.907 1.00 38.61 ? 482 HOH A O   1 
HETATM 4246 O O   . HOH J 4 .   ? -1.522  -10.542 -18.737 1.00 15.87 ? 483 HOH A O   1 
HETATM 4247 O O   . HOH J 4 .   ? -18.326 -20.845 -1.968  1.00 14.77 ? 484 HOH A O   1 
HETATM 4248 O O   . HOH J 4 .   ? 8.545   5.523   -0.533  1.00 18.57 ? 485 HOH A O   1 
HETATM 4249 O O   . HOH J 4 .   ? -0.029  -21.843 -16.764 1.00 16.34 ? 486 HOH A O   1 
HETATM 4250 O O   . HOH J 4 .   ? -31.313 -16.963 -22.134 1.00 24.66 ? 487 HOH A O   1 
HETATM 4251 O O   . HOH J 4 .   ? -8.435  -10.800 -0.476  1.00 25.15 ? 488 HOH A O   1 
HETATM 4252 O O   . HOH J 4 .   ? 4.869   -0.174  -24.096 1.00 29.86 ? 489 HOH A O   1 
HETATM 4253 O O   . HOH J 4 .   ? -32.008 0.674   -16.632 1.00 37.58 ? 490 HOH A O   1 
HETATM 4254 O O   . HOH J 4 .   ? 5.290   -7.954  -32.477 1.00 32.51 ? 491 HOH A O   1 
HETATM 4255 O O   . HOH J 4 .   ? -20.131 3.574   -28.970 1.00 20.34 ? 492 HOH A O   1 
HETATM 4256 O O   . HOH J 4 .   ? -21.534 -15.796 -2.236  1.00 24.78 ? 493 HOH A O   1 
HETATM 4257 O O   . HOH J 4 .   ? -13.288 -5.545  -37.199 1.00 18.23 ? 494 HOH A O   1 
HETATM 4258 O O   . HOH J 4 .   ? -26.491 -12.404 -6.179  1.00 24.41 ? 495 HOH A O   1 
HETATM 4259 O O   . HOH J 4 .   ? -22.585 4.021   -29.728 1.00 34.04 ? 496 HOH A O   1 
HETATM 4260 O O   . HOH J 4 .   ? 2.669   -12.352 0.647   1.00 16.38 ? 497 HOH A O   1 
HETATM 4261 O O   . HOH J 4 .   ? -7.885  3.278   -37.708 1.00 23.87 ? 498 HOH A O   1 
HETATM 4262 O O   . HOH J 4 .   ? -11.163 -3.060  -8.446  1.00 12.52 ? 499 HOH A O   1 
HETATM 4263 O O   . HOH J 4 .   ? -18.921 10.224  -12.629 1.00 27.40 ? 500 HOH A O   1 
HETATM 4264 O O   . HOH J 4 .   ? -2.531  -21.601 -2.992  1.00 24.66 ? 501 HOH A O   1 
HETATM 4265 O O   . HOH J 4 .   ? -15.266 0.991   -38.826 1.00 17.70 ? 502 HOH A O   1 
HETATM 4266 O O   . HOH J 4 .   ? -15.261 1.170   -15.578 1.00 9.31  ? 503 HOH A O   1 
HETATM 4267 O O   . HOH J 4 .   ? 2.978   -0.772  -21.312 1.00 27.45 ? 504 HOH A O   1 
HETATM 4268 O O   . HOH J 4 .   ? -6.584  0.956   -17.822 1.00 21.70 ? 505 HOH A O   1 
HETATM 4269 O O   . HOH J 4 .   ? 4.555   -18.698 -24.169 1.00 22.34 ? 506 HOH A O   1 
HETATM 4270 O O   . HOH J 4 .   ? -10.433 -21.926 2.182   1.00 11.62 ? 507 HOH A O   1 
HETATM 4271 O O   . HOH J 4 .   ? -1.557  -7.427  -30.653 1.00 24.50 ? 508 HOH A O   1 
HETATM 4272 O O   . HOH J 4 .   ? -19.301 2.099   -7.548  1.00 23.17 ? 509 HOH A O   1 
HETATM 4273 O O   . HOH J 4 .   ? 12.364  -3.664  4.888   1.00 18.81 ? 510 HOH A O   1 
HETATM 4274 O O   . HOH J 4 .   ? -0.534  -12.533 -25.236 1.00 14.57 ? 511 HOH A O   1 
HETATM 4275 O O   . HOH J 4 .   ? -13.729 -21.626 -19.292 1.00 23.43 ? 512 HOH A O   1 
HETATM 4276 O O   . HOH J 4 .   ? -13.828 4.954   -29.241 1.00 26.96 ? 513 HOH A O   1 
HETATM 4277 O O   . HOH J 4 .   ? -8.193  4.389   -34.160 1.00 17.82 ? 514 HOH A O   1 
HETATM 4278 O O   . HOH J 4 .   ? -13.420 3.872   -10.848 1.00 11.79 ? 515 HOH A O   1 
HETATM 4279 O O   . HOH J 4 .   ? -9.013  0.358   -18.774 1.00 9.66  ? 516 HOH A O   1 
HETATM 4280 O O   . HOH J 4 .   ? -15.052 -22.351 2.595   1.00 13.78 ? 517 HOH A O   1 
HETATM 4281 O O   . HOH J 4 .   ? -9.384  -12.793 7.709   1.00 15.15 ? 518 HOH A O   1 
HETATM 4282 O O   . HOH J 4 .   ? 1.717   -13.754 2.752   1.00 21.12 ? 519 HOH A O   1 
HETATM 4283 O O   . HOH J 4 .   ? -13.687 -19.451 -23.775 1.00 13.07 ? 520 HOH A O   1 
HETATM 4284 O O   . HOH J 4 .   ? -12.972 -13.241 5.015   1.00 15.13 ? 521 HOH A O   1 
HETATM 4285 O O   . HOH J 4 .   ? -8.097  -12.530 -34.033 1.00 16.21 ? 522 HOH A O   1 
HETATM 4286 O O   . HOH J 4 .   ? -7.161  -21.401 3.403   1.00 13.41 ? 523 HOH A O   1 
HETATM 4287 O O   . HOH J 4 .   ? 4.815   3.750   -8.135  1.00 23.03 ? 524 HOH A O   1 
HETATM 4288 O O   . HOH J 4 .   ? 9.662   -6.873  10.099  1.00 24.29 ? 525 HOH A O   1 
HETATM 4289 O O   . HOH J 4 .   ? -6.799  -14.717 -31.432 1.00 15.72 ? 526 HOH A O   1 
HETATM 4290 O O   . HOH J 4 .   ? -4.592  -0.628  1.388   1.00 15.48 ? 527 HOH A O   1 
HETATM 4291 O O   . HOH J 4 .   ? -0.589  4.284   -30.419 1.00 21.59 ? 528 HOH A O   1 
HETATM 4292 O O   . HOH J 4 .   ? -28.267 -11.543 -10.858 1.00 33.72 ? 529 HOH A O   1 
HETATM 4293 O O   . HOH J 4 .   ? -35.525 -10.461 -20.283 1.00 32.24 ? 530 HOH A O   1 
HETATM 4294 O O   . HOH J 4 .   ? -8.572  -3.754  -36.387 1.00 19.19 ? 531 HOH A O   1 
HETATM 4295 O O   . HOH J 4 .   ? -4.761  0.061   -32.826 1.00 20.61 ? 532 HOH A O   1 
HETATM 4296 O O   . HOH J 4 .   ? -25.841 3.406   -24.760 1.00 23.51 ? 533 HOH A O   1 
HETATM 4297 O O   . HOH J 4 .   ? -25.635 1.013   -5.683  1.00 22.28 ? 534 HOH A O   1 
HETATM 4298 O O   . HOH J 4 .   ? -21.622 -18.789 -1.006  1.00 15.44 ? 535 HOH A O   1 
HETATM 4299 O O   . HOH J 4 .   ? -22.632 -11.309 -0.348  1.00 19.99 ? 536 HOH A O   1 
HETATM 4300 O O   . HOH J 4 .   ? -4.854  3.447   -31.213 1.00 15.25 ? 537 HOH A O   1 
HETATM 4301 O O   . HOH J 4 .   ? -1.317  -0.354  5.002   1.00 23.05 ? 538 HOH A O   1 
HETATM 4302 O O   . HOH J 4 .   ? -34.662 -6.281  -17.074 1.00 35.28 ? 539 HOH A O   1 
HETATM 4303 O O   . HOH J 4 .   ? -12.204 8.605   -28.580 1.00 30.24 ? 540 HOH A O   1 
HETATM 4304 O O   . HOH J 4 .   ? 0.713   -22.703 -5.051  1.00 23.69 ? 541 HOH A O   1 
HETATM 4305 O O   . HOH J 4 .   ? -25.428 -14.274 -28.208 1.00 22.58 ? 542 HOH A O   1 
HETATM 4306 O O   . HOH J 4 .   ? -5.773  -27.316 -15.536 1.00 32.91 ? 543 HOH A O   1 
HETATM 4307 O O   . HOH J 4 .   ? -1.236  -1.921  -12.608 1.00 7.44  ? 544 HOH A O   1 
HETATM 4308 O O   . HOH J 4 .   ? -2.677  -13.702 -28.886 1.00 30.56 ? 545 HOH A O   1 
HETATM 4309 O O   . HOH J 4 .   ? -16.147 -22.272 -4.731  1.00 17.07 ? 546 HOH A O   1 
HETATM 4310 O O   . HOH J 4 .   ? -28.340 1.215   -9.920  1.00 34.45 ? 547 HOH A O   1 
HETATM 4311 O O   . HOH J 4 .   ? 5.233   -12.936 -6.048  1.00 18.16 ? 548 HOH A O   1 
HETATM 4312 O O   A HOH J 4 .   ? -10.624 -10.363 11.973  0.37 17.84 ? 549 HOH A O   1 
HETATM 4313 O O   B HOH J 4 .   ? -11.625 -12.202 12.439  0.63 26.17 ? 549 HOH A O   1 
HETATM 4314 O O   . HOH J 4 .   ? -19.524 -15.497 -20.370 1.00 16.96 ? 550 HOH A O   1 
HETATM 4315 O O   . HOH J 4 .   ? -3.546  -9.350  -31.173 1.00 19.38 ? 551 HOH A O   1 
HETATM 4316 O O   . HOH J 4 .   ? -25.832 5.507   -26.532 1.00 37.08 ? 552 HOH A O   1 
HETATM 4317 O O   . HOH J 4 .   ? -19.766 -1.732  0.919   1.00 27.47 ? 553 HOH A O   1 
HETATM 4318 O O   . HOH J 4 .   ? -16.714 -12.947 -32.677 1.00 25.61 ? 554 HOH A O   1 
HETATM 4319 O O   B HOH J 4 .   ? -13.687 -16.047 7.484   0.87 22.98 ? 555 HOH A O   1 
HETATM 4320 O O   . HOH J 4 .   ? -11.896 -29.333 -20.648 1.00 17.75 ? 556 HOH A O   1 
HETATM 4321 O O   . HOH J 4 .   ? -4.980  -22.353 -18.962 1.00 30.15 ? 557 HOH A O   1 
HETATM 4322 O O   . HOH J 4 .   ? -5.017  4.028   -14.156 1.00 30.75 ? 558 HOH A O   1 
HETATM 4323 O O   . HOH J 4 .   ? 1.316   -2.425  -17.205 1.00 28.03 ? 559 HOH A O   1 
HETATM 4324 O O   . HOH J 4 .   ? -19.440 -3.700  -39.229 1.00 22.34 ? 560 HOH A O   1 
HETATM 4325 O O   . HOH J 4 .   ? -15.948 -21.861 -25.622 1.00 24.32 ? 561 HOH A O   1 
HETATM 4326 O O   . HOH J 4 .   ? -18.037 -8.226  3.562   1.00 14.42 ? 562 HOH A O   1 
HETATM 4327 O O   . HOH J 4 .   ? -3.384  -12.854 11.157  1.00 31.49 ? 563 HOH A O   1 
HETATM 4328 O O   . HOH J 4 .   ? 3.707   -21.002 -9.729  1.00 25.98 ? 564 HOH A O   1 
HETATM 4329 O O   . HOH J 4 .   ? -14.407 0.239   -1.265  1.00 18.14 ? 565 HOH A O   1 
HETATM 4330 O O   . HOH J 4 .   ? -27.780 8.532   -15.618 1.00 31.68 ? 566 HOH A O   1 
HETATM 4331 O O   . HOH J 4 .   ? 3.309   3.496   -24.876 1.00 33.45 ? 567 HOH A O   1 
HETATM 4332 O O   . HOH J 4 .   ? -21.053 -19.042 -22.497 1.00 18.38 ? 568 HOH A O   1 
HETATM 4333 O O   . HOH J 4 .   ? -22.123 7.493   -22.673 1.00 35.70 ? 569 HOH A O   1 
HETATM 4334 O O   . HOH J 4 .   ? 11.192  -11.360 9.569   1.00 35.26 ? 570 HOH A O   1 
HETATM 4335 O O   . HOH J 4 .   ? 12.961  -2.310  -5.981  1.00 24.11 ? 571 HOH A O   1 
HETATM 4336 O O   . HOH J 4 .   ? -5.428  -21.381 -2.274  1.00 30.86 ? 572 HOH A O   1 
HETATM 4337 O O   A HOH J 4 .   ? 5.373   -18.138 -2.253  0.58 19.35 ? 573 HOH A O   1 
HETATM 4338 O O   B HOH J 4 .   ? 6.356   -19.527 -0.715  0.42 20.13 ? 573 HOH A O   1 
HETATM 4339 O O   . HOH J 4 .   ? 7.078   -16.988 -13.748 1.00 36.47 ? 574 HOH A O   1 
HETATM 4340 O O   . HOH J 4 .   ? -11.623 -23.340 9.091   1.00 15.12 ? 575 HOH A O   1 
HETATM 4341 O O   . HOH J 4 .   ? -19.328 -15.567 -4.693  1.00 9.30  ? 576 HOH A O   1 
HETATM 4342 O O   . HOH J 4 .   ? -17.426 -19.437 3.797   1.00 17.49 ? 577 HOH A O   1 
HETATM 4343 O O   . HOH J 4 .   ? -11.110 -11.659 -37.622 1.00 35.10 ? 578 HOH A O   1 
HETATM 4344 O O   . HOH J 4 .   ? -10.426 -3.247  2.909   1.00 24.80 ? 579 HOH A O   1 
HETATM 4345 O O   . HOH J 4 .   ? -18.140 -5.756  2.370   1.00 18.83 ? 580 HOH A O   1 
HETATM 4346 O O   . HOH J 4 .   ? -1.845  -24.495 -11.174 1.00 21.55 ? 581 HOH A O   1 
HETATM 4347 O O   . HOH J 4 .   ? -14.192 -23.496 -17.689 1.00 18.27 ? 582 HOH A O   1 
HETATM 4348 O O   . HOH J 4 .   ? -4.657  -22.163 -4.788  1.00 20.80 ? 583 HOH A O   1 
HETATM 4349 O O   . HOH J 4 .   ? -7.357  -22.595 -24.278 1.00 33.12 ? 584 HOH A O   1 
HETATM 4350 O O   . HOH J 4 .   ? -20.815 -5.440  -0.958  1.00 17.49 ? 585 HOH A O   1 
HETATM 4351 O O   . HOH J 4 .   ? -30.384 -12.039 -4.987  1.00 41.78 ? 586 HOH A O   1 
HETATM 4352 O O   . HOH J 4 .   ? 8.518   0.645   9.823   1.00 33.48 ? 587 HOH A O   1 
HETATM 4353 O O   . HOH J 4 .   ? -20.717 3.428   -10.319 1.00 23.08 ? 588 HOH A O   1 
HETATM 4354 O O   . HOH J 4 .   ? -34.233 -7.279  -14.508 1.00 16.84 ? 589 HOH A O   1 
HETATM 4355 O O   . HOH J 4 .   ? -0.302  -21.541 -14.008 1.00 18.54 ? 590 HOH A O   1 
HETATM 4356 O O   . HOH J 4 .   ? -8.584  6.972   -24.648 1.00 27.49 ? 591 HOH A O   1 
HETATM 4357 O O   . HOH J 4 .   ? 8.631   -12.740 -19.338 1.00 20.28 ? 592 HOH A O   1 
HETATM 4358 O O   . HOH J 4 .   ? -21.858 4.634   -15.096 1.00 30.46 ? 593 HOH A O   1 
HETATM 4359 O O   . HOH J 4 .   ? -17.499 7.612   -15.598 1.00 21.37 ? 594 HOH A O   1 
HETATM 4360 O O   . HOH J 4 .   ? -18.146 -21.277 -9.562  1.00 28.04 ? 595 HOH A O   1 
HETATM 4361 O O   . HOH J 4 .   ? -6.722  -16.532 -29.204 1.00 15.70 ? 596 HOH A O   1 
HETATM 4362 O O   . HOH J 4 .   ? -2.131  6.116   -8.017  1.00 28.25 ? 597 HOH A O   1 
HETATM 4363 O O   . HOH J 4 .   ? -7.688  -20.080 -2.805  1.00 17.13 ? 598 HOH A O   1 
HETATM 4364 O O   . HOH J 4 .   ? -16.856 -25.460 -15.011 1.00 33.64 ? 599 HOH A O   1 
HETATM 4365 O O   . HOH J 4 .   ? -30.518 -2.408  -9.699  1.00 28.23 ? 600 HOH A O   1 
HETATM 4366 O O   . HOH J 4 .   ? 1.442   -23.150 -22.997 1.00 36.14 ? 601 HOH A O   1 
HETATM 4367 O O   . HOH J 4 .   ? -13.862 -2.893  2.828   1.00 21.39 ? 602 HOH A O   1 
HETATM 4368 O O   . HOH J 4 .   ? -17.442 -14.701 -29.979 1.00 15.71 ? 603 HOH A O   1 
HETATM 4369 O O   . HOH J 4 .   ? 0.696   2.833   -23.534 1.00 27.31 ? 604 HOH A O   1 
HETATM 4370 O O   . HOH J 4 .   ? -27.875 -15.023 -25.598 1.00 20.48 ? 605 HOH A O   1 
HETATM 4371 O O   . HOH J 4 .   ? -5.471  3.282   -34.114 1.00 14.86 ? 606 HOH A O   1 
HETATM 4372 O O   . HOH J 4 .   ? -26.784 -5.677  -25.510 1.00 33.77 ? 607 HOH A O   1 
HETATM 4373 O O   . HOH J 4 .   ? -3.309  -22.293 -22.463 1.00 25.24 ? 608 HOH A O   1 
HETATM 4374 O O   . HOH J 4 .   ? 0.631   -2.846  -14.458 1.00 22.29 ? 609 HOH A O   1 
HETATM 4375 O O   . HOH J 4 .   ? 5.765   -3.568  -32.403 1.00 21.55 ? 610 HOH A O   1 
HETATM 4376 O O   . HOH J 4 .   ? -20.819 -13.917 -22.231 1.00 15.70 ? 611 HOH A O   1 
HETATM 4377 O O   . HOH J 4 .   ? 11.262  -4.900  -27.594 1.00 51.71 ? 612 HOH A O   1 
HETATM 4378 O O   . HOH J 4 .   ? -8.798  -20.093 11.329  1.00 24.50 ? 613 HOH A O   1 
HETATM 4379 O O   . HOH J 4 .   ? -7.217  8.271   -21.497 1.00 42.91 ? 614 HOH A O   1 
HETATM 4380 O O   . HOH J 4 .   ? 13.100  -8.758  7.676   1.00 43.46 ? 615 HOH A O   1 
HETATM 4381 O O   . HOH J 4 .   ? -31.796 0.019   -9.180  1.00 40.34 ? 616 HOH A O   1 
HETATM 4382 O O   A HOH J 4 .   ? -9.702  3.559   -1.627  0.52 12.31 ? 617 HOH A O   1 
HETATM 4383 O O   B HOH J 4 .   ? -8.749  4.390   -0.366  0.48 12.58 ? 617 HOH A O   1 
HETATM 4384 O O   . HOH J 4 .   ? 6.272   -11.126 5.466   1.00 22.83 ? 618 HOH A O   1 
HETATM 4385 O O   . HOH J 4 .   ? -6.070  -7.684  -23.853 1.00 20.52 ? 619 HOH A O   1 
HETATM 4386 O O   . HOH J 4 .   ? -15.969 6.475   -26.022 1.00 16.69 ? 620 HOH A O   1 
HETATM 4387 O O   . HOH J 4 .   ? -16.913 8.766   -23.290 1.00 34.21 ? 621 HOH A O   1 
HETATM 4388 O O   . HOH J 4 .   ? -24.685 -11.094 -30.763 1.00 27.95 ? 622 HOH A O   1 
HETATM 4389 O O   . HOH J 4 .   ? -3.071  -19.935 9.108   1.00 26.60 ? 623 HOH A O   1 
HETATM 4390 O O   . HOH J 4 .   ? 12.010  -3.322  -9.643  1.00 33.92 ? 624 HOH A O   1 
HETATM 4391 O O   . HOH J 4 .   ? 4.417   -1.005  9.294   1.00 22.62 ? 625 HOH A O   1 
HETATM 4392 O O   . HOH J 4 .   ? -19.357 -9.704  -36.007 1.00 34.71 ? 626 HOH A O   1 
HETATM 4393 O O   . HOH J 4 .   ? -23.336 -12.906 -29.187 1.00 16.84 ? 627 HOH A O   1 
HETATM 4394 O O   . HOH J 4 .   ? -25.429 -15.637 -10.573 1.00 35.77 ? 628 HOH A O   1 
HETATM 4395 O O   . HOH J 4 .   ? -6.883  5.908   -22.630 1.00 18.16 ? 629 HOH A O   1 
HETATM 4396 O O   . HOH J 4 .   ? -19.366 -13.302 -32.209 1.00 35.37 ? 630 HOH A O   1 
HETATM 4397 O O   . HOH J 4 .   ? -8.835  -7.392  -35.152 1.00 21.95 ? 631 HOH A O   1 
HETATM 4398 O O   . HOH J 4 .   ? -13.415 -27.722 -10.031 1.00 35.37 ? 632 HOH A O   1 
HETATM 4399 O O   B HOH J 4 .   ? -5.226  5.366   -19.860 1.00 30.77 ? 633 HOH A O   1 
HETATM 4400 O O   . HOH J 4 .   ? -11.474 4.120   -32.934 1.00 16.98 ? 634 HOH A O   1 
HETATM 4401 O O   . HOH J 4 .   ? -1.047  -18.956 4.744   1.00 15.26 ? 635 HOH A O   1 
HETATM 4402 O O   B HOH J 4 .   ? 3.045   6.885   -3.097  0.99 29.78 ? 636 HOH A O   1 
HETATM 4403 O O   . HOH J 4 .   ? -27.097 -8.137  -7.066  1.00 23.98 ? 637 HOH A O   1 
HETATM 4404 O O   . HOH J 4 .   ? 3.872   -5.698  11.725  1.00 31.46 ? 638 HOH A O   1 
HETATM 4405 O O   . HOH J 4 .   ? -14.476 -16.250 -30.431 1.00 12.21 ? 639 HOH A O   1 
HETATM 4406 O O   . HOH J 4 .   ? 2.335   -22.330 -7.594  1.00 31.15 ? 640 HOH A O   1 
HETATM 4407 O O   . HOH J 4 .   ? -6.051  -17.588 10.339  1.00 20.99 ? 641 HOH A O   1 
HETATM 4408 O O   . HOH J 4 .   ? -12.228 -14.323 7.410   1.00 33.73 ? 642 HOH A O   1 
HETATM 4409 O O   . HOH J 4 .   ? -31.260 3.716   -17.425 1.00 34.20 ? 643 HOH A O   1 
HETATM 4410 O O   . HOH J 4 .   ? 15.203  -4.751  0.318   1.00 20.40 ? 644 HOH A O   1 
HETATM 4411 O O   . HOH J 4 .   ? -21.864 -18.537 1.649   1.00 14.56 ? 645 HOH A O   1 
HETATM 4412 O O   . HOH J 4 .   ? 7.462   -14.404 -13.157 1.00 18.85 ? 646 HOH A O   1 
HETATM 4413 O O   . HOH J 4 .   ? 7.201   -10.446 2.203   1.00 30.66 ? 647 HOH A O   1 
HETATM 4414 O O   . HOH J 4 .   ? 7.477   -9.250  -3.546  1.00 22.47 ? 648 HOH A O   1 
HETATM 4415 O O   . HOH J 4 .   ? -3.412  0.526   -34.731 1.00 26.86 ? 649 HOH A O   1 
HETATM 4416 O O   . HOH J 4 .   ? -12.994 -15.646 14.120  1.00 26.37 ? 650 HOH A O   1 
HETATM 4417 O O   . HOH J 4 .   ? -16.240 -19.957 -13.233 1.00 29.18 ? 651 HOH A O   1 
HETATM 4418 O O   . HOH J 4 .   ? 10.502  -9.627  0.738   1.00 38.16 ? 652 HOH A O   1 
HETATM 4419 O O   A HOH J 4 .   ? 12.676  -0.973  8.857   0.53 15.96 ? 653 HOH A O   1 
HETATM 4420 O O   B HOH J 4 .   ? 13.625  0.725   9.640   0.47 18.86 ? 653 HOH A O   1 
HETATM 4421 O O   . HOH J 4 .   ? -25.906 9.624   -17.910 1.00 29.56 ? 654 HOH A O   1 
HETATM 4422 O O   . HOH J 4 .   ? -13.916 -23.732 -4.867  1.00 21.78 ? 655 HOH A O   1 
HETATM 4423 O O   . HOH J 4 .   ? -2.370  3.233   2.738   1.00 30.14 ? 656 HOH A O   1 
HETATM 4424 O O   A HOH J 4 .   ? 6.590   -19.727 -6.110  0.49 18.21 ? 657 HOH A O   1 
HETATM 4425 O O   B HOH J 4 .   ? 8.011   -18.361 -6.623  0.51 24.55 ? 657 HOH A O   1 
HETATM 4426 O O   . HOH J 4 .   ? 7.031   -11.808 -1.245  1.00 29.58 ? 658 HOH A O   1 
HETATM 4427 O O   . HOH J 4 .   ? -16.388 -17.618 12.227  1.00 28.95 ? 659 HOH A O   1 
HETATM 4428 O O   . HOH J 4 .   ? 11.290  0.322   -8.130  1.00 37.69 ? 660 HOH A O   1 
HETATM 4429 O O   . HOH J 4 .   ? -33.929 -12.152 -13.305 1.00 38.71 ? 661 HOH A O   1 
HETATM 4430 O O   . HOH J 4 .   ? 13.155  0.825   -3.484  1.00 25.96 ? 662 HOH A O   1 
HETATM 4431 O O   . HOH J 4 .   ? -9.234  -18.145 13.985  1.00 25.86 ? 663 HOH A O   1 
HETATM 4432 O O   . HOH J 4 .   ? -19.970 10.302  -14.761 1.00 39.15 ? 664 HOH A O   1 
HETATM 4433 O O   . HOH J 4 .   ? -4.134  -5.983  -32.513 1.00 20.48 ? 665 HOH A O   1 
HETATM 4434 O O   . HOH J 4 .   ? 6.329   -19.025 -16.298 1.00 46.07 ? 666 HOH A O   1 
HETATM 4435 O O   . HOH J 4 .   ? -5.037  2.569   -19.501 1.00 25.40 ? 667 HOH A O   1 
HETATM 4436 O O   . HOH J 4 .   ? -6.497  -21.700 -26.211 1.00 36.22 ? 668 HOH A O   1 
HETATM 4437 O O   . HOH J 4 .   ? -28.102 -7.591  -32.707 1.00 29.46 ? 669 HOH A O   1 
HETATM 4438 O O   . HOH J 4 .   ? -4.616  6.061   -1.123  1.00 24.48 ? 670 HOH A O   1 
HETATM 4439 O O   . HOH J 4 .   ? 9.499   -6.397  -29.867 1.00 44.73 ? 671 HOH A O   1 
HETATM 4440 O O   . HOH J 4 .   ? -26.044 -8.527  -34.205 1.00 31.05 ? 672 HOH A O   1 
HETATM 4441 O O   . HOH J 4 .   ? 3.995   2.025   7.425   1.00 36.70 ? 673 HOH A O   1 
HETATM 4442 O O   . HOH J 4 .   ? -0.857  5.300   -22.462 1.00 40.60 ? 674 HOH A O   1 
HETATM 4443 O O   . HOH J 4 .   ? -2.278  5.958   -20.085 1.00 37.83 ? 675 HOH A O   1 
HETATM 4444 O O   . HOH J 4 .   ? -21.293 -14.365 -30.878 1.00 28.43 ? 676 HOH A O   1 
HETATM 4445 O O   . HOH J 4 .   ? 3.597   -21.237 -22.267 1.00 34.37 ? 677 HOH A O   1 
HETATM 4446 O O   . HOH J 4 .   ? -2.966  -12.426 -26.660 1.00 21.02 ? 678 HOH A O   1 
HETATM 4447 O O   . HOH J 4 .   ? -7.870  -3.032  3.708   1.00 23.20 ? 679 HOH A O   1 
HETATM 4448 O O   . HOH J 4 .   ? -9.454  9.003   -20.775 1.00 26.82 ? 680 HOH A O   1 
HETATM 4449 O O   . HOH J 4 .   ? 8.085   -8.446  -28.391 1.00 37.73 ? 681 HOH A O   1 
HETATM 4450 O O   . HOH J 4 .   ? 2.534   -18.954 1.540   1.00 34.51 ? 682 HOH A O   1 
HETATM 4451 O O   . HOH J 4 .   ? 5.742   -11.236 7.923   1.00 36.67 ? 683 HOH A O   1 
HETATM 4452 O O   . HOH J 4 .   ? -35.858 -10.505 -23.209 1.00 34.07 ? 684 HOH A O   1 
HETATM 4453 O O   . HOH J 4 .   ? -31.141 -20.060 -19.012 1.00 31.40 ? 685 HOH A O   1 
HETATM 4454 O O   . HOH J 4 .   ? -3.165  7.007   -3.243  1.00 26.59 ? 686 HOH A O   1 
HETATM 4455 O O   . HOH J 4 .   ? -14.671 -27.234 -14.042 1.00 32.95 ? 687 HOH A O   1 
HETATM 4456 O O   . HOH J 4 .   ? 2.310   -21.141 -13.455 1.00 36.37 ? 688 HOH A O   1 
HETATM 4457 O O   . HOH J 4 .   ? 14.931  -4.446  -6.837  1.00 30.99 ? 689 HOH A O   1 
HETATM 4458 O O   . HOH J 4 .   ? 13.602  -8.965  -0.699  1.00 38.04 ? 690 HOH A O   1 
HETATM 4459 O O   . HOH J 4 .   ? -22.675 -9.447  -2.228  1.00 24.01 ? 691 HOH A O   1 
HETATM 4460 O O   . HOH J 4 .   ? -7.385  -23.227 -4.947  1.00 24.10 ? 692 HOH A O   1 
HETATM 4461 O O   . HOH J 4 .   ? 1.904   -24.328 -21.032 1.00 39.77 ? 693 HOH A O   1 
HETATM 4462 O O   . HOH J 4 .   ? 4.412   -11.582 -32.207 1.00 46.79 ? 694 HOH A O   1 
HETATM 4463 O O   . HOH J 4 .   ? -30.101 -5.626  -8.885  1.00 29.54 ? 695 HOH A O   1 
HETATM 4464 O O   . HOH J 4 .   ? -2.817  0.668   3.077   1.00 23.31 ? 696 HOH A O   1 
HETATM 4465 O O   . HOH J 4 .   ? 3.003   -13.257 5.379   1.00 39.52 ? 697 HOH A O   1 
HETATM 4466 O O   . HOH J 4 .   ? -34.100 -7.898  -11.050 1.00 33.26 ? 698 HOH A O   1 
HETATM 4467 O O   . HOH J 4 .   ? -10.301 7.969   -22.964 1.00 23.38 ? 699 HOH A O   1 
HETATM 4468 O O   . HOH J 4 .   ? -14.744 -26.145 -4.683  1.00 31.94 ? 700 HOH A O   1 
HETATM 4469 O O   . HOH J 4 .   ? -7.963  -10.112 -35.062 1.00 19.76 ? 701 HOH A O   1 
HETATM 4470 O O   . HOH J 4 .   ? -14.414 -11.171 3.687   1.00 29.54 ? 702 HOH A O   1 
HETATM 4471 O O   . HOH J 4 .   ? -0.605  -24.803 -19.797 1.00 30.80 ? 703 HOH A O   1 
HETATM 4472 O O   . HOH J 4 .   ? 4.299   3.671   -14.247 1.00 38.18 ? 704 HOH A O   1 
HETATM 4473 O O   . HOH J 4 .   ? -3.960  5.197   -16.273 1.00 34.00 ? 705 HOH A O   1 
HETATM 4474 O O   . HOH J 4 .   ? -5.216  0.894   -0.720  1.00 15.56 ? 706 HOH A O   1 
HETATM 4475 O O   . HOH J 4 .   ? -24.397 -19.410 -9.178  1.00 29.96 ? 707 HOH A O   1 
HETATM 4476 O O   . HOH J 4 .   ? 8.118   -4.881  -31.657 1.00 40.31 ? 708 HOH A O   1 
HETATM 4477 O O   . HOH J 4 .   ? -12.508 -21.895 -24.055 1.00 21.10 ? 709 HOH A O   1 
HETATM 4478 O O   . HOH J 4 .   ? 8.304   -7.988  -24.104 1.00 22.31 ? 710 HOH A O   1 
HETATM 4479 O O   . HOH J 4 .   ? -16.817 -3.647  -39.815 1.00 26.35 ? 711 HOH A O   1 
HETATM 4480 O O   . HOH J 4 .   ? -33.005 -5.609  -22.381 1.00 33.22 ? 712 HOH A O   1 
HETATM 4481 O O   . HOH J 4 .   ? -29.963 -7.981  -34.727 1.00 36.53 ? 713 HOH A O   1 
HETATM 4482 O O   . HOH J 4 .   ? -16.526 -4.257  4.029   1.00 32.23 ? 714 HOH A O   1 
HETATM 4483 O O   . HOH J 4 .   ? -24.423 -17.321 -19.289 1.00 39.08 ? 715 HOH A O   1 
HETATM 4484 O O   . HOH J 4 .   ? -15.121 7.950   -28.139 1.00 31.09 ? 716 HOH A O   1 
HETATM 4485 O O   . HOH J 4 .   ? -27.426 -6.921  -28.224 1.00 38.10 ? 717 HOH A O   1 
HETATM 4486 O O   . HOH J 4 .   ? -9.125  0.492   -41.484 1.00 30.47 ? 718 HOH A O   1 
HETATM 4487 O O   . HOH J 4 .   ? -3.499  -11.176 -33.038 1.00 23.02 ? 719 HOH A O   1 
HETATM 4488 O O   . HOH J 4 .   ? -17.053 -19.868 -19.937 1.00 23.44 ? 720 HOH A O   1 
HETATM 4489 O O   . HOH J 4 .   ? -2.235  -23.288 -18.018 1.00 20.61 ? 721 HOH A O   1 
HETATM 4490 O O   . HOH J 4 .   ? -3.748  -16.555 9.653   1.00 35.11 ? 722 HOH A O   1 
HETATM 4491 O O   . HOH J 4 .   ? -34.892 -8.265  -19.820 1.00 28.84 ? 723 HOH A O   1 
HETATM 4492 O O   . HOH J 4 .   ? -9.293  -7.251  -37.550 1.00 38.08 ? 724 HOH A O   1 
HETATM 4493 O O   . HOH J 4 .   ? -18.769 -24.063 -11.317 1.00 34.32 ? 725 HOH A O   1 
HETATM 4494 O O   . HOH J 4 .   ? -32.543 -6.761  -9.453  1.00 36.47 ? 726 HOH A O   1 
HETATM 4495 O O   . HOH J 4 .   ? 16.681  -2.162  -3.109  1.00 29.76 ? 727 HOH A O   1 
HETATM 4496 O O   . HOH J 4 .   ? -4.177  -25.658 -11.641 1.00 26.13 ? 728 HOH A O   1 
HETATM 4497 O O   . HOH J 4 .   ? -4.347  -13.605 -31.294 1.00 21.26 ? 729 HOH A O   1 
HETATM 4498 O O   . HOH J 4 .   ? -16.563 -7.706  5.640   1.00 25.46 ? 730 HOH A O   1 
HETATM 4499 O O   . HOH J 4 .   ? -9.457  -28.093 -9.033  1.00 27.82 ? 731 HOH A O   1 
HETATM 4500 O O   . HOH J 4 .   ? -10.787 -8.174  13.092  1.00 29.93 ? 732 HOH A O   1 
HETATM 4501 O O   . HOH J 4 .   ? -24.151 -6.001  -3.898  1.00 41.27 ? 733 HOH A O   1 
HETATM 4502 O O   . HOH J 4 .   ? 0.281   -3.400  -37.992 1.00 37.03 ? 734 HOH A O   1 
HETATM 4503 O O   . HOH J 4 .   ? -12.022 -3.243  4.719   1.00 40.72 ? 735 HOH A O   1 
HETATM 4504 O O   A HOH J 4 .   ? -20.331 4.399   -8.180  0.46 14.75 ? 736 HOH A O   1 
HETATM 4505 O O   B HOH J 4 .   ? -21.946 4.249   -6.906  0.54 20.70 ? 736 HOH A O   1 
HETATM 4506 O O   . HOH J 4 .   ? 9.803   -8.375  -7.173  1.00 28.24 ? 737 HOH A O   1 
HETATM 4507 O O   . HOH J 4 .   ? -7.192  -26.075 -5.335  1.00 39.00 ? 738 HOH A O   1 
HETATM 4508 O O   . HOH J 4 .   ? -29.145 -16.915 -10.644 1.00 45.18 ? 739 HOH A O   1 
HETATM 4509 O O   . HOH J 4 .   ? 5.291   -15.595 -6.484  1.00 16.53 ? 740 HOH A O   1 
HETATM 4510 O O   . HOH J 4 .   ? -10.526 -5.015  -37.972 1.00 27.13 ? 741 HOH A O   1 
HETATM 4511 O O   . HOH J 4 .   ? -27.122 -1.259  -6.631  1.00 40.32 ? 742 HOH A O   1 
HETATM 4512 O O   . HOH J 4 .   ? -11.756 -27.788 -5.978  1.00 43.33 ? 743 HOH A O   1 
HETATM 4513 O O   . HOH J 4 .   ? 7.526   -11.747 -6.681  1.00 30.24 ? 744 HOH A O   1 
HETATM 4514 O O   . HOH J 4 .   ? -19.807 -19.516 -20.196 1.00 23.84 ? 745 HOH A O   1 
HETATM 4515 O O   . HOH J 4 .   ? -26.481 -18.742 -7.587  1.00 21.34 ? 746 HOH A O   1 
HETATM 4516 O O   . HOH J 4 .   ? -25.722 -9.960  -5.121  1.00 32.43 ? 747 HOH A O   1 
HETATM 4517 O O   . HOH J 4 .   ? -15.217 -20.636 -21.636 1.00 17.65 ? 748 HOH A O   1 
HETATM 4518 O O   . HOH J 4 .   ? -22.852 -9.835  3.472   1.00 40.03 ? 749 HOH A O   1 
HETATM 4519 O O   . HOH J 4 .   ? -35.804 -15.951 -16.882 1.00 24.05 ? 750 HOH A O   1 
HETATM 4520 O O   A HOH J 4 .   ? -15.915 -20.631 -17.761 0.53 19.97 ? 751 HOH A O   1 
HETATM 4521 O O   B HOH J 4 .   ? -14.873 -19.672 -16.665 0.47 16.95 ? 751 HOH A O   1 
HETATM 4522 O O   . HOH J 4 .   ? -4.766  3.497   0.250   1.00 21.17 ? 752 HOH A O   1 
HETATM 4523 O O   A HOH J 4 .   ? -10.824 -7.724  6.859   0.63 25.61 ? 753 HOH A O   1 
HETATM 4524 O O   B HOH J 4 .   ? -12.838 -8.929  7.110   0.37 21.75 ? 753 HOH A O   1 
HETATM 4525 O O   A HOH J 4 .   ? -0.912  -24.635 -6.110  0.60 24.16 ? 754 HOH A O   1 
HETATM 4526 O O   B HOH J 4 .   ? -2.295  -24.187 -4.994  0.40 18.62 ? 754 HOH A O   1 
HETATM 4527 O O   . HOH J 4 .   ? -5.510  -27.094 -9.981  1.00 38.89 ? 755 HOH A O   1 
HETATM 4528 O O   . HOH J 4 .   ? 6.545   -17.194 -4.534  1.00 20.26 ? 756 HOH A O   1 
HETATM 4529 O O   . HOH J 4 .   ? -7.903  -3.477  6.463   1.00 28.62 ? 757 HOH A O   1 
HETATM 4530 O O   . HOH J 4 .   ? 14.325  -5.204  5.525   1.00 29.80 ? 758 HOH A O   1 
HETATM 4531 O O   . HOH J 4 .   ? 9.418   -6.474  -21.944 1.00 33.72 ? 759 HOH A O   1 
HETATM 4532 O O   . HOH J 4 .   ? -13.576 -0.425  1.088   1.00 26.24 ? 760 HOH A O   1 
HETATM 4533 O O   . HOH J 4 .   ? -6.013  -20.175 11.145  1.00 31.13 ? 761 HOH A O   1 
HETATM 4534 O O   . HOH J 4 .   ? -12.934 -17.710 15.425  1.00 29.41 ? 762 HOH A O   1 
HETATM 4535 O O   . HOH J 4 .   ? -8.378  0.789   1.729   1.00 27.01 ? 763 HOH A O   1 
HETATM 4536 O O   . HOH J 4 .   ? -14.533 7.798   -23.985 1.00 21.54 ? 764 HOH A O   1 
HETATM 4537 O O   . HOH J 4 .   ? -30.327 -19.305 -21.505 1.00 29.53 ? 765 HOH A O   1 
HETATM 4538 O O   . HOH J 4 .   ? -24.935 -13.070 -32.978 1.00 28.91 ? 766 HOH A O   1 
HETATM 4539 O O   . HOH J 4 .   ? -7.057  0.364   5.326   1.00 29.06 ? 767 HOH A O   1 
HETATM 4540 O O   . HOH J 4 .   ? -3.376  -26.694 -14.027 1.00 41.90 ? 768 HOH A O   1 
HETATM 4541 O O   . HOH J 4 .   ? -27.932 -3.743  -5.088  1.00 26.02 ? 769 HOH A O   1 
HETATM 4542 O O   . HOH J 4 .   ? -1.678  -2.752  10.843  1.00 33.23 ? 770 HOH A O   1 
HETATM 4543 O O   . HOH J 4 .   ? -13.323 -24.500 -0.794  1.00 17.82 ? 771 HOH A O   1 
HETATM 4544 O O   A HOH J 4 .   ? 15.712  -4.184  2.947   0.58 22.76 ? 772 HOH A O   1 
HETATM 4545 O O   B HOH J 4 .   ? 15.583  -2.371  3.986   0.42 19.25 ? 772 HOH A O   1 
HETATM 4546 O O   . HOH J 4 .   ? -5.225  -9.495  -34.747 1.00 31.94 ? 773 HOH A O   1 
HETATM 4547 O O   . HOH J 4 .   ? 0.991   -21.617 -27.775 1.00 35.31 ? 774 HOH A O   1 
HETATM 4548 O O   . HOH J 4 .   ? -7.690  0.034   -44.008 1.00 26.03 ? 775 HOH A O   1 
HETATM 4549 O O   . HOH J 4 .   ? -6.018  -0.799  -39.307 1.00 40.22 ? 776 HOH A O   1 
HETATM 4550 O O   . HOH J 4 .   ? 5.212   -12.580 0.849   1.00 25.45 ? 777 HOH A O   1 
HETATM 4551 O O   . HOH J 4 .   ? -34.794 -9.656  -13.056 1.00 15.97 ? 778 HOH A O   1 
HETATM 4552 O O   . HOH J 4 .   ? -0.977  -24.315 -13.566 1.00 34.00 ? 779 HOH A O   1 
HETATM 4553 O O   . HOH J 4 .   ? -6.895  -0.670  3.018   1.00 23.56 ? 780 HOH A O   1 
HETATM 4554 O O   . HOH J 4 .   ? -4.988  1.864   5.136   1.00 38.15 ? 781 HOH A O   1 
HETATM 4555 O O   . HOH J 4 .   ? -7.088  3.599   1.758   1.00 36.73 ? 782 HOH A O   1 
HETATM 4556 O O   . HOH J 4 .   ? -20.741 -8.369  4.727   1.00 27.76 ? 783 HOH A O   1 
HETATM 4557 O O   . HOH J 4 .   ? -0.667  -5.138  11.188  1.00 26.99 ? 784 HOH A O   1 
HETATM 4558 O O   . HOH J 4 .   ? -3.964  -16.886 -28.586 1.00 25.47 ? 785 HOH A O   1 
HETATM 4559 O O   . HOH J 4 .   ? 7.121   -17.399 -10.712 1.00 35.89 ? 786 HOH A O   1 
HETATM 4560 O O   . HOH J 4 .   ? -16.968 -5.231  6.430   1.00 34.41 ? 787 HOH A O   1 
HETATM 4561 O O   . HOH J 4 .   ? -22.854 -6.830  -1.897  1.00 27.44 ? 788 HOH A O   1 
HETATM 4562 O O   . HOH J 4 .   ? 15.754  -7.340  0.129   1.00 27.05 ? 789 HOH A O   1 
HETATM 4563 O O   . HOH J 4 .   ? -27.200 -10.598 -30.097 1.00 40.49 ? 790 HOH A O   1 
HETATM 4564 O O   . HOH J 4 .   ? -12.217 -7.571  11.164  1.00 44.31 ? 791 HOH A O   1 
HETATM 4565 O O   . HOH J 4 .   ? 3.409   -21.037 -27.087 1.00 31.86 ? 792 HOH A O   1 
HETATM 4566 O O   . HOH J 4 .   ? 7.031   -16.429 -8.368  1.00 23.73 ? 793 HOH A O   1 
HETATM 4567 O O   A HOH J 4 .   ? -26.959 -6.090  -3.342  0.61 27.92 ? 794 HOH A O   1 
HETATM 4568 O O   B HOH J 4 .   ? -27.085 -7.213  -1.499  0.39 20.08 ? 794 HOH A O   1 
HETATM 4569 O O   . HOH J 4 .   ? -27.999 -10.562 -8.433  1.00 32.48 ? 795 HOH A O   1 
HETATM 4570 O O   . HOH J 4 .   ? -11.707 -23.730 -3.152  1.00 25.41 ? 796 HOH A O   1 
HETATM 4571 O O   . HOH J 4 .   ? -10.564 10.259  -24.671 1.00 33.02 ? 797 HOH A O   1 
HETATM 4572 O O   . HOH J 4 .   ? -9.316  -22.473 -2.778  1.00 23.86 ? 798 HOH A O   1 
HETATM 4573 O O   . HOH J 4 .   ? -10.410 -26.396 -3.549  1.00 27.62 ? 799 HOH A O   1 
HETATM 4574 O O   . HOH K 4 .   ? -21.800 -2.900  -1.870  1.00 21.37 ? 401 HOH B O   1 
HETATM 4575 O O   . HOH K 4 .   ? -11.196 35.644  4.095   1.00 23.29 ? 402 HOH B O   1 
HETATM 4576 O O   . HOH K 4 .   ? -34.003 1.830   10.266  1.00 31.14 ? 403 HOH B O   1 
HETATM 4577 O O   . HOH K 4 .   ? -1.978  6.677   -12.047 1.00 38.77 ? 404 HOH B O   1 
HETATM 4578 O O   . HOH K 4 .   ? -19.518 13.411  -23.170 1.00 31.18 ? 405 HOH B O   1 
HETATM 4579 O O   . HOH K 4 .   ? 6.847   20.296  -8.382  1.00 18.56 ? 406 HOH B O   1 
HETATM 4580 O O   . HOH K 4 .   ? -22.796 1.767   6.710   1.00 24.65 ? 407 HOH B O   1 
HETATM 4581 O O   . HOH K 4 .   ? -28.567 35.559  -5.947  1.00 18.46 ? 408 HOH B O   1 
HETATM 4582 O O   . HOH K 4 .   ? 8.885   24.281  -13.656 1.00 40.51 ? 409 HOH B O   1 
HETATM 4583 O O   . HOH K 4 .   ? -20.394 8.189   -8.490  1.00 24.37 ? 410 HOH B O   1 
HETATM 4584 O O   . HOH K 4 .   ? -19.569 15.721  18.558  1.00 35.78 ? 411 HOH B O   1 
HETATM 4585 O O   . HOH K 4 .   ? -33.982 7.360   9.705   1.00 22.89 ? 412 HOH B O   1 
HETATM 4586 O O   . HOH K 4 .   ? -10.065 36.408  -17.996 1.00 22.37 ? 413 HOH B O   1 
HETATM 4587 O O   . HOH K 4 .   ? -21.869 19.735  -4.269  1.00 16.48 ? 414 HOH B O   1 
HETATM 4588 O O   . HOH K 4 .   ? -14.601 22.871  -2.725  1.00 21.03 ? 415 HOH B O   1 
HETATM 4589 O O   . HOH K 4 .   ? -23.191 18.633  -7.545  1.00 18.09 ? 416 HOH B O   1 
HETATM 4590 O O   . HOH K 4 .   ? 7.999   24.826  -19.604 1.00 38.02 ? 417 HOH B O   1 
HETATM 4591 O O   . HOH K 4 .   ? -12.744 28.714  -3.905  1.00 11.90 ? 418 HOH B O   1 
HETATM 4592 O O   . HOH K 4 .   ? -26.243 37.449  -4.479  1.00 12.61 ? 419 HOH B O   1 
HETATM 4593 O O   . HOH K 4 .   ? 1.514   40.186  -24.024 1.00 32.68 ? 420 HOH B O   1 
HETATM 4594 O O   . HOH K 4 .   ? -29.630 24.790  -15.757 1.00 12.27 ? 421 HOH B O   1 
HETATM 4595 O O   . HOH K 4 .   ? -31.103 14.453  8.905   1.00 26.59 ? 422 HOH B O   1 
HETATM 4596 O O   . HOH K 4 .   ? -29.501 28.846  -22.052 1.00 32.83 ? 423 HOH B O   1 
HETATM 4597 O O   . HOH K 4 .   ? -29.293 9.374   -10.847 1.00 33.24 ? 424 HOH B O   1 
HETATM 4598 O O   . HOH K 4 .   ? -29.756 23.166  -24.505 1.00 23.13 ? 425 HOH B O   1 
HETATM 4599 O O   . HOH K 4 .   ? -11.767 19.877  -30.912 1.00 19.33 ? 426 HOH B O   1 
HETATM 4600 O O   . HOH K 4 .   ? -22.710 2.356   2.942   1.00 22.97 ? 427 HOH B O   1 
HETATM 4601 O O   . HOH K 4 .   ? -14.192 37.540  5.583   1.00 28.54 ? 428 HOH B O   1 
HETATM 4602 O O   . HOH K 4 .   ? -25.646 16.642  11.445  1.00 20.13 ? 429 HOH B O   1 
HETATM 4603 O O   . HOH K 4 .   ? -22.288 17.758  17.416  1.00 18.91 ? 430 HOH B O   1 
HETATM 4604 O O   . HOH K 4 .   ? -40.309 6.001   5.953   1.00 36.77 ? 431 HOH B O   1 
HETATM 4605 O O   . HOH K 4 .   ? -21.488 17.519  -9.815  1.00 13.41 ? 432 HOH B O   1 
HETATM 4606 O O   B HOH K 4 .   ? 2.226   16.366  -20.233 0.60 23.51 ? 433 HOH B O   1 
HETATM 4607 O O   . HOH K 4 .   ? -29.177 23.009  9.298   1.00 23.86 ? 434 HOH B O   1 
HETATM 4608 O O   . HOH K 4 .   ? -20.907 11.105  17.906  1.00 33.07 ? 435 HOH B O   1 
HETATM 4609 O O   . HOH K 4 .   ? -7.594  25.809  -31.548 1.00 21.91 ? 436 HOH B O   1 
HETATM 4610 O O   . HOH K 4 .   ? -20.522 10.550  -10.457 1.00 26.87 ? 437 HOH B O   1 
HETATM 4611 O O   . HOH K 4 .   ? -15.693 2.551   -0.982  1.00 16.82 ? 438 HOH B O   1 
HETATM 4612 O O   . HOH K 4 .   ? -17.299 0.606   -2.082  1.00 39.19 ? 439 HOH B O   1 
HETATM 4613 O O   . HOH K 4 .   ? -26.910 32.592  -0.624  1.00 12.14 ? 440 HOH B O   1 
HETATM 4614 O O   . HOH K 4 .   ? -21.807 17.992  -17.984 1.00 17.15 ? 441 HOH B O   1 
HETATM 4615 O O   . HOH K 4 .   ? 4.201   27.075  -12.186 1.00 31.62 ? 442 HOH B O   1 
HETATM 4616 O O   . HOH K 4 .   ? -6.793  31.690  -35.708 1.00 33.25 ? 443 HOH B O   1 
HETATM 4617 O O   . HOH K 4 .   ? 2.556   19.896  3.116   1.00 35.00 ? 444 HOH B O   1 
HETATM 4618 O O   . HOH K 4 .   ? -32.042 21.635  -15.286 1.00 39.86 ? 445 HOH B O   1 
HETATM 4619 O O   . HOH K 4 .   ? -9.308  23.743  15.914  1.00 24.90 ? 446 HOH B O   1 
HETATM 4620 O O   . HOH K 4 .   ? -14.720 28.322  -27.057 1.00 22.11 ? 447 HOH B O   1 
HETATM 4621 O O   . HOH K 4 .   ? 7.229   25.931  -1.598  1.00 28.01 ? 448 HOH B O   1 
HETATM 4622 O O   . HOH K 4 .   ? -31.253 28.297  -18.160 1.00 38.59 ? 449 HOH B O   1 
HETATM 4623 O O   . HOH K 4 .   ? -25.799 -5.656  -0.201  1.00 40.69 ? 450 HOH B O   1 
HETATM 4624 O O   A HOH K 4 .   ? -2.714  8.878   -16.463 0.60 17.43 ? 451 HOH B O   1 
HETATM 4625 O O   B HOH K 4 .   ? -4.403  7.858   -17.386 0.40 18.50 ? 451 HOH B O   1 
HETATM 4626 O O   . HOH K 4 .   ? -16.421 5.759   0.621   1.00 15.90 ? 452 HOH B O   1 
HETATM 4627 O O   . HOH K 4 .   ? -26.803 28.754  -11.975 1.00 10.09 ? 453 HOH B O   1 
HETATM 4628 O O   . HOH K 4 .   ? -17.116 22.008  16.763  1.00 12.49 ? 454 HOH B O   1 
HETATM 4629 O O   . HOH K 4 .   ? -24.399 28.423  9.315   1.00 27.05 ? 455 HOH B O   1 
HETATM 4630 O O   . HOH K 4 .   ? -22.175 25.129  -8.793  1.00 13.60 ? 456 HOH B O   1 
HETATM 4631 O O   . HOH K 4 .   ? -21.641 13.869  18.731  1.00 31.95 ? 457 HOH B O   1 
HETATM 4632 O O   . HOH K 4 .   ? -31.550 16.178  0.678   1.00 19.13 ? 458 HOH B O   1 
HETATM 4633 O O   . HOH K 4 .   ? -24.150 28.887  -11.077 1.00 14.07 ? 459 HOH B O   1 
HETATM 4634 O O   . HOH K 4 .   ? -32.675 21.172  -0.266  1.00 18.05 ? 460 HOH B O   1 
HETATM 4635 O O   . HOH K 4 .   ? -15.636 38.558  -0.353  1.00 20.37 ? 461 HOH B O   1 
HETATM 4636 O O   B HOH K 4 .   ? -27.545 2.396   -4.366  0.90 14.93 ? 462 HOH B O   1 
HETATM 4637 O O   . HOH K 4 .   ? -6.998  6.847   0.201   1.00 24.87 ? 463 HOH B O   1 
HETATM 4638 O O   . HOH K 4 .   ? 0.041   29.203  -2.817  1.00 22.77 ? 464 HOH B O   1 
HETATM 4639 O O   . HOH K 4 .   ? 1.607   30.607  -4.726  1.00 18.96 ? 465 HOH B O   1 
HETATM 4640 O O   . HOH K 4 .   ? -12.105 4.232   -3.081  1.00 10.80 ? 466 HOH B O   1 
HETATM 4641 O O   . HOH K 4 .   ? -34.955 14.838  6.711   1.00 37.37 ? 467 HOH B O   1 
HETATM 4642 O O   . HOH K 4 .   ? -11.450 14.631  13.132  1.00 16.96 ? 468 HOH B O   1 
HETATM 4643 O O   . HOH K 4 .   ? -30.445 18.779  -16.063 1.00 34.02 ? 469 HOH B O   1 
HETATM 4644 O O   . HOH K 4 .   ? -10.682 11.559  -20.763 1.00 15.31 ? 470 HOH B O   1 
HETATM 4645 O O   . HOH K 4 .   ? 5.231   14.870  -4.393  1.00 24.33 ? 471 HOH B O   1 
HETATM 4646 O O   . HOH K 4 .   ? -33.056 19.430  -2.479  1.00 17.83 ? 472 HOH B O   1 
HETATM 4647 O O   . HOH K 4 .   ? -26.651 18.174  -16.105 1.00 28.79 ? 473 HOH B O   1 
HETATM 4648 O O   . HOH K 4 .   ? -2.527  9.434   2.175   1.00 24.97 ? 474 HOH B O   1 
HETATM 4649 O O   . HOH K 4 .   ? 7.340   25.367  -11.773 1.00 31.21 ? 475 HOH B O   1 
HETATM 4650 O O   . HOH K 4 .   ? -23.419 31.757  1.227   1.00 13.68 ? 476 HOH B O   1 
HETATM 4651 O O   . HOH K 4 .   ? -9.907  35.174  -8.141  1.00 15.37 ? 477 HOH B O   1 
HETATM 4652 O O   . HOH K 4 .   ? 0.963   11.356  -1.080  1.00 31.97 ? 478 HOH B O   1 
HETATM 4653 O O   . HOH K 4 .   ? -28.839 28.013  9.963   1.00 24.54 ? 479 HOH B O   1 
HETATM 4654 O O   A HOH K 4 .   ? -18.607 6.255   -8.589  0.56 12.93 ? 480 HOH B O   1 
HETATM 4655 O O   B HOH K 4 .   ? -15.634 2.746   -8.515  0.44 4.58  ? 480 HOH B O   1 
HETATM 4656 O O   . HOH K 4 .   ? -6.531  7.917   -15.257 1.00 23.78 ? 481 HOH B O   1 
HETATM 4657 O O   . HOH K 4 .   ? -2.507  20.538  8.745   1.00 23.84 ? 482 HOH B O   1 
HETATM 4658 O O   . HOH K 4 .   ? -13.636 23.508  15.498  1.00 13.20 ? 483 HOH B O   1 
HETATM 4659 O O   . HOH K 4 .   ? -0.742  16.543  3.251   1.00 23.64 ? 484 HOH B O   1 
HETATM 4660 O O   . HOH K 4 .   ? -9.768  30.410  -26.671 1.00 16.87 ? 485 HOH B O   1 
HETATM 4661 O O   . HOH K 4 .   ? -33.313 2.291   -1.333  1.00 20.69 ? 486 HOH B O   1 
HETATM 4662 O O   . HOH K 4 .   ? -26.784 16.506  -21.866 1.00 29.05 ? 487 HOH B O   1 
HETATM 4663 O O   . HOH K 4 .   ? -31.562 22.287  -4.343  1.00 11.10 ? 488 HOH B O   1 
HETATM 4664 O O   . HOH K 4 .   ? -36.879 11.976  -2.408  1.00 27.90 ? 489 HOH B O   1 
HETATM 4665 O O   . HOH K 4 .   ? -13.591 4.123   -0.980  1.00 18.30 ? 490 HOH B O   1 
HETATM 4666 O O   . HOH K 4 .   ? -27.163 34.880  -15.681 1.00 18.67 ? 491 HOH B O   1 
HETATM 4667 O O   . HOH K 4 .   ? -22.820 30.173  -13.207 1.00 14.26 ? 492 HOH B O   1 
HETATM 4668 O O   . HOH K 4 .   ? -25.032 26.520  -10.502 1.00 13.92 ? 493 HOH B O   1 
HETATM 4669 O O   . HOH K 4 .   ? -25.547 19.717  -19.607 1.00 11.85 ? 494 HOH B O   1 
HETATM 4670 O O   . HOH K 4 .   ? 1.302   13.854  -19.063 1.00 21.04 ? 495 HOH B O   1 
HETATM 4671 O O   . HOH K 4 .   ? -18.256 20.169  -26.540 1.00 25.11 ? 496 HOH B O   1 
HETATM 4672 O O   . HOH K 4 .   ? -16.285 12.252  -6.629  1.00 17.15 ? 497 HOH B O   1 
HETATM 4673 O O   . HOH K 4 .   ? -21.994 28.217  -17.237 1.00 13.58 ? 498 HOH B O   1 
HETATM 4674 O O   . HOH K 4 .   ? -12.043 6.724   -11.835 1.00 8.10  ? 499 HOH B O   1 
HETATM 4675 O O   . HOH K 4 .   ? -10.632 8.602   -9.388  1.00 13.38 ? 500 HOH B O   1 
HETATM 4676 O O   . HOH K 4 .   ? -35.121 16.787  2.900   1.00 31.97 ? 501 HOH B O   1 
HETATM 4677 O O   . HOH K 4 .   ? -5.359  30.771  4.175   1.00 26.25 ? 502 HOH B O   1 
HETATM 4678 O O   . HOH K 4 .   ? -15.879 15.806  7.234   1.00 21.10 ? 503 HOH B O   1 
HETATM 4679 O O   . HOH K 4 .   ? -16.794 37.786  -2.760  1.00 26.63 ? 504 HOH B O   1 
HETATM 4680 O O   . HOH K 4 .   ? -29.235 29.905  0.811   1.00 15.58 ? 505 HOH B O   1 
HETATM 4681 O O   . HOH K 4 .   ? -4.808  21.572  6.315   1.00 10.31 ? 506 HOH B O   1 
HETATM 4682 O O   . HOH K 4 .   ? -1.466  15.644  7.915   1.00 19.07 ? 507 HOH B O   1 
HETATM 4683 O O   . HOH K 4 .   ? -28.870 7.581   -7.120  1.00 21.41 ? 508 HOH B O   1 
HETATM 4684 O O   . HOH K 4 .   ? -3.402  30.207  -28.713 1.00 21.47 ? 509 HOH B O   1 
HETATM 4685 O O   . HOH K 4 .   ? -22.723 14.486  -7.990  1.00 8.90  ? 510 HOH B O   1 
HETATM 4686 O O   . HOH K 4 .   ? -14.506 16.228  21.958  1.00 21.15 ? 511 HOH B O   1 
HETATM 4687 O O   . HOH K 4 .   ? 2.324   34.528  -18.333 1.00 22.37 ? 512 HOH B O   1 
HETATM 4688 O O   . HOH K 4 .   ? -14.725 6.474   12.942  1.00 35.80 ? 513 HOH B O   1 
HETATM 4689 O O   . HOH K 4 .   ? -12.872 13.204  -3.662  1.00 12.08 ? 514 HOH B O   1 
HETATM 4690 O O   . HOH K 4 .   ? -23.555 0.484   -4.208  1.00 19.16 ? 515 HOH B O   1 
HETATM 4691 O O   . HOH K 4 .   ? -26.471 33.950  -19.526 1.00 21.79 ? 516 HOH B O   1 
HETATM 4692 O O   . HOH K 4 .   ? 3.013   35.582  -28.494 1.00 22.57 ? 517 HOH B O   1 
HETATM 4693 O O   . HOH K 4 .   ? -1.332  10.094  -19.303 1.00 38.09 ? 518 HOH B O   1 
HETATM 4694 O O   . HOH K 4 .   ? -14.692 15.820  -14.333 1.00 10.22 ? 519 HOH B O   1 
HETATM 4695 O O   . HOH K 4 .   ? -14.883 13.261  14.898  1.00 27.71 ? 520 HOH B O   1 
HETATM 4696 O O   . HOH K 4 .   ? -24.819 3.538   7.703   1.00 28.17 ? 521 HOH B O   1 
HETATM 4697 O O   . HOH K 4 .   ? -4.986  8.088   -5.723  1.00 21.28 ? 522 HOH B O   1 
HETATM 4698 O O   . HOH K 4 .   ? -30.594 13.144  11.992  1.00 21.50 ? 523 HOH B O   1 
HETATM 4699 O O   . HOH K 4 .   ? -0.363  36.107  -17.505 1.00 40.54 ? 524 HOH B O   1 
HETATM 4700 O O   . HOH K 4 .   ? -8.540  13.309  -11.903 1.00 9.55  ? 525 HOH B O   1 
HETATM 4701 O O   . HOH K 4 .   ? -21.845 1.604   0.546   1.00 25.88 ? 526 HOH B O   1 
HETATM 4702 O O   . HOH K 4 .   ? -3.244  18.392  -24.243 1.00 16.84 ? 527 HOH B O   1 
HETATM 4703 O O   . HOH K 4 .   ? 4.715   24.368  -22.874 1.00 29.24 ? 528 HOH B O   1 
HETATM 4704 O O   . HOH K 4 .   ? -13.060 11.362  -14.585 1.00 9.56  ? 529 HOH B O   1 
HETATM 4705 O O   . HOH K 4 .   ? -19.800 17.431  21.128  1.00 16.52 ? 530 HOH B O   1 
HETATM 4706 O O   . HOH K 4 .   ? -16.422 33.273  8.555   1.00 15.81 ? 531 HOH B O   1 
HETATM 4707 O O   . HOH K 4 .   ? -26.833 16.704  8.803   1.00 15.49 ? 532 HOH B O   1 
HETATM 4708 O O   . HOH K 4 .   ? -2.775  31.713  -4.901  1.00 34.25 ? 533 HOH B O   1 
HETATM 4709 O O   . HOH K 4 .   ? -10.342 10.830  10.832  1.00 26.88 ? 534 HOH B O   1 
HETATM 4710 O O   . HOH K 4 .   ? -7.524  33.487  -24.596 1.00 25.66 ? 535 HOH B O   1 
HETATM 4711 O O   . HOH K 4 .   ? -10.950 15.657  17.154  1.00 29.25 ? 536 HOH B O   1 
HETATM 4712 O O   . HOH K 4 .   ? -19.392 27.759  9.176   1.00 21.94 ? 537 HOH B O   1 
HETATM 4713 O O   . HOH K 4 .   ? -20.902 12.771  -14.369 1.00 35.49 ? 538 HOH B O   1 
HETATM 4714 O O   . HOH K 4 .   ? -9.770  32.081  -35.484 1.00 42.68 ? 539 HOH B O   1 
HETATM 4715 O O   . HOH K 4 .   ? 10.235  19.696  -6.298  1.00 18.40 ? 540 HOH B O   1 
HETATM 4716 O O   . HOH K 4 .   ? -20.113 37.075  -5.768  1.00 26.24 ? 541 HOH B O   1 
HETATM 4717 O O   . HOH K 4 .   ? -24.854 30.704  -23.399 1.00 18.52 ? 542 HOH B O   1 
HETATM 4718 O O   . HOH K 4 .   ? -8.270  18.542  17.727  1.00 31.52 ? 543 HOH B O   1 
HETATM 4719 O O   . HOH K 4 .   ? -10.022 6.191   0.646   1.00 24.51 ? 544 HOH B O   1 
HETATM 4720 O O   . HOH K 4 .   ? -29.151 20.729  3.220   1.00 15.53 ? 545 HOH B O   1 
HETATM 4721 O O   . HOH K 4 .   ? -17.579 14.769  20.214  1.00 21.22 ? 546 HOH B O   1 
HETATM 4722 O O   . HOH K 4 .   ? -9.751  20.825  20.332  1.00 22.60 ? 547 HOH B O   1 
HETATM 4723 O O   . HOH K 4 .   ? -14.882 20.260  -29.572 1.00 15.19 ? 548 HOH B O   1 
HETATM 4724 O O   . HOH K 4 .   ? -14.799 13.310  -22.611 1.00 26.97 ? 549 HOH B O   1 
HETATM 4725 O O   . HOH K 4 .   ? -8.398  16.195  16.355  1.00 27.13 ? 550 HOH B O   1 
HETATM 4726 O O   . HOH K 4 .   ? -9.697  25.600  -33.395 1.00 28.48 ? 551 HOH B O   1 
HETATM 4727 O O   . HOH K 4 .   ? -13.030 37.696  -9.798  1.00 31.92 ? 552 HOH B O   1 
HETATM 4728 O O   . HOH K 4 .   ? -19.837 6.088   3.226   1.00 11.57 ? 553 HOH B O   1 
HETATM 4729 O O   . HOH K 4 .   ? -0.776  20.358  10.448  1.00 45.18 ? 554 HOH B O   1 
HETATM 4730 O O   . HOH K 4 .   ? -25.882 38.589  -11.228 1.00 21.04 ? 555 HOH B O   1 
HETATM 4731 O O   . HOH K 4 .   ? -17.287 25.292  -14.467 1.00 20.58 ? 556 HOH B O   1 
HETATM 4732 O O   . HOH K 4 .   ? -26.585 14.433  13.314  1.00 27.63 ? 557 HOH B O   1 
HETATM 4733 O O   . HOH K 4 .   ? -6.246  11.073  9.765   1.00 20.02 ? 558 HOH B O   1 
HETATM 4734 O O   . HOH K 4 .   ? -32.943 26.499  -5.568  1.00 10.56 ? 559 HOH B O   1 
HETATM 4735 O O   . HOH K 4 .   ? 11.573  26.164  -10.129 1.00 18.16 ? 560 HOH B O   1 
HETATM 4736 O O   . HOH K 4 .   ? -8.077  27.389  9.831   1.00 18.16 ? 561 HOH B O   1 
HETATM 4737 O O   A HOH K 4 .   ? -10.217 34.517  -2.252  0.49 15.46 ? 562 HOH B O   1 
HETATM 4738 O O   B HOH K 4 .   ? -9.359  35.410  -1.133  0.51 17.21 ? 562 HOH B O   1 
HETATM 4739 O O   . HOH K 4 .   ? 2.789   24.277  -16.427 1.00 23.29 ? 563 HOH B O   1 
HETATM 4740 O O   . HOH K 4 .   ? -8.695  26.632  13.524  1.00 26.36 ? 564 HOH B O   1 
HETATM 4741 O O   . HOH K 4 .   ? -2.849  22.939  11.417  1.00 36.62 ? 565 HOH B O   1 
HETATM 4742 O O   . HOH K 4 .   ? -24.995 18.405  14.930  1.00 17.98 ? 566 HOH B O   1 
HETATM 4743 O O   A HOH K 4 .   ? -14.370 22.251  -32.666 0.66 24.48 ? 567 HOH B O   1 
HETATM 4744 O O   B HOH K 4 .   ? -12.998 23.468  -33.617 0.34 18.98 ? 567 HOH B O   1 
HETATM 4745 O O   . HOH K 4 .   ? -32.620 7.541   14.312  1.00 46.40 ? 568 HOH B O   1 
HETATM 4746 O O   . HOH K 4 .   ? -5.911  24.558  11.477  1.00 19.69 ? 569 HOH B O   1 
HETATM 4747 O O   . HOH K 4 .   ? -24.914 5.818   11.823  1.00 16.80 ? 570 HOH B O   1 
HETATM 4748 O O   . HOH K 4 .   ? -17.967 6.785   11.359  1.00 14.64 ? 571 HOH B O   1 
HETATM 4749 O O   . HOH K 4 .   ? -5.795  34.351  -15.635 1.00 19.14 ? 572 HOH B O   1 
HETATM 4750 O O   . HOH K 4 .   ? -20.625 32.650  -15.668 1.00 23.26 ? 573 HOH B O   1 
HETATM 4751 O O   . HOH K 4 .   ? -16.682 35.691  -14.392 1.00 19.63 ? 574 HOH B O   1 
HETATM 4752 O O   . HOH K 4 .   ? 2.418   23.650  0.360   1.00 23.32 ? 575 HOH B O   1 
HETATM 4753 O O   . HOH K 4 .   ? -27.249 4.811   14.377  1.00 39.60 ? 576 HOH B O   1 
HETATM 4754 O O   . HOH K 4 .   ? -14.028 7.307   5.957   1.00 19.12 ? 577 HOH B O   1 
HETATM 4755 O O   . HOH K 4 .   ? -20.442 30.568  -18.291 1.00 21.33 ? 578 HOH B O   1 
HETATM 4756 O O   . HOH K 4 .   ? -3.412  10.946  4.389   1.00 19.16 ? 579 HOH B O   1 
HETATM 4757 O O   . HOH K 4 .   ? -16.246 24.656  10.556  1.00 21.35 ? 580 HOH B O   1 
HETATM 4758 O O   . HOH K 4 .   ? -29.330 26.557  -23.706 1.00 23.93 ? 581 HOH B O   1 
HETATM 4759 O O   . HOH K 4 .   ? -17.167 14.717  -13.879 1.00 17.57 ? 582 HOH B O   1 
HETATM 4760 O O   A HOH K 4 .   ? -12.888 37.572  -5.276  0.56 16.42 ? 583 HOH B O   1 
HETATM 4761 O O   B HOH K 4 .   ? -11.369 39.255  -6.088  0.44 20.42 ? 583 HOH B O   1 
HETATM 4762 O O   . HOH K 4 .   ? -22.764 12.610  -10.593 1.00 36.86 ? 584 HOH B O   1 
HETATM 4763 O O   . HOH K 4 .   ? -13.116 8.134   8.282   1.00 29.30 ? 585 HOH B O   1 
HETATM 4764 O O   . HOH K 4 .   ? -32.393 27.544  -8.106  1.00 11.47 ? 586 HOH B O   1 
HETATM 4765 O O   . HOH K 4 .   ? -2.786  29.528  -9.129  1.00 21.68 ? 587 HOH B O   1 
HETATM 4766 O O   . HOH K 4 .   ? -3.989  30.132  -6.804  1.00 23.38 ? 588 HOH B O   1 
HETATM 4767 O O   . HOH K 4 .   ? -26.775 36.893  -13.325 1.00 16.73 ? 589 HOH B O   1 
HETATM 4768 O O   . HOH K 4 .   ? -27.445 29.945  2.892   1.00 14.59 ? 590 HOH B O   1 
HETATM 4769 O O   . HOH K 4 .   ? -1.279  27.097  5.679   1.00 22.77 ? 591 HOH B O   1 
HETATM 4770 O O   . HOH K 4 .   ? -6.100  34.102  -18.889 1.00 19.04 ? 592 HOH B O   1 
HETATM 4771 O O   . HOH K 4 .   ? -7.606  30.013  1.213   1.00 24.17 ? 593 HOH B O   1 
HETATM 4772 O O   . HOH K 4 .   ? -3.561  8.588   -8.664  1.00 22.18 ? 594 HOH B O   1 
HETATM 4773 O O   . HOH K 4 .   ? -2.159  35.832  -20.523 1.00 30.65 ? 595 HOH B O   1 
HETATM 4774 O O   . HOH K 4 .   ? -39.389 11.080  4.139   1.00 26.68 ? 596 HOH B O   1 
HETATM 4775 O O   . HOH K 4 .   ? 1.189   33.497  -12.833 1.00 37.70 ? 597 HOH B O   1 
HETATM 4776 O O   . HOH K 4 .   ? -16.682 13.263  -20.560 1.00 16.48 ? 598 HOH B O   1 
HETATM 4777 O O   . HOH K 4 .   ? -2.358  19.886  13.945  1.00 27.59 ? 599 HOH B O   1 
HETATM 4778 O O   . HOH K 4 .   ? -36.943 4.769   10.228  1.00 36.14 ? 600 HOH B O   1 
HETATM 4779 O O   . HOH K 4 .   ? -17.698 9.938   -21.112 1.00 41.95 ? 601 HOH B O   1 
HETATM 4780 O O   . HOH K 4 .   ? -22.009 4.615   4.286   1.00 14.19 ? 602 HOH B O   1 
HETATM 4781 O O   . HOH K 4 .   ? -19.125 28.444  -22.649 1.00 14.82 ? 603 HOH B O   1 
HETATM 4782 O O   . HOH K 4 .   ? -7.613  14.345  -23.686 1.00 18.74 ? 604 HOH B O   1 
HETATM 4783 O O   . HOH K 4 .   ? -31.329 25.363  -1.918  1.00 14.95 ? 605 HOH B O   1 
HETATM 4784 O O   . HOH K 4 .   ? -6.167  9.521   7.192   1.00 18.39 ? 606 HOH B O   1 
HETATM 4785 O O   . HOH K 4 .   ? 1.793   27.389  -28.443 1.00 34.89 ? 607 HOH B O   1 
HETATM 4786 O O   . HOH K 4 .   ? -32.503 29.923  -11.570 1.00 20.33 ? 608 HOH B O   1 
HETATM 4787 O O   . HOH K 4 .   ? -4.194  28.107  10.145  1.00 35.61 ? 609 HOH B O   1 
HETATM 4788 O O   A HOH K 4 .   ? -4.922  16.886  14.430  0.61 23.53 ? 610 HOH B O   1 
HETATM 4789 O O   B HOH K 4 .   ? -6.218  18.423  15.059  0.39 21.74 ? 610 HOH B O   1 
HETATM 4790 O O   . HOH K 4 .   ? -0.157  32.631  -15.110 1.00 18.73 ? 611 HOH B O   1 
HETATM 4791 O O   . HOH K 4 .   ? -20.761 33.826  -12.663 1.00 21.71 ? 612 HOH B O   1 
HETATM 4792 O O   . HOH K 4 .   ? -19.617 1.653   -2.605  1.00 19.95 ? 613 HOH B O   1 
HETATM 4793 O O   . HOH K 4 .   ? -18.395 35.583  -3.294  1.00 26.43 ? 614 HOH B O   1 
HETATM 4794 O O   . HOH K 4 .   ? -15.275 38.085  -5.298  1.00 41.76 ? 615 HOH B O   1 
HETATM 4795 O O   . HOH K 4 .   ? -16.770 11.884  -13.432 1.00 17.82 ? 616 HOH B O   1 
HETATM 4796 O O   . HOH K 4 .   ? -22.740 14.038  -20.487 1.00 30.59 ? 617 HOH B O   1 
HETATM 4797 O O   . HOH K 4 .   ? -27.251 -1.646  2.249   1.00 37.47 ? 618 HOH B O   1 
HETATM 4798 O O   . HOH K 4 .   ? -25.397 17.931  -11.672 1.00 34.96 ? 619 HOH B O   1 
HETATM 4799 O O   . HOH K 4 .   ? -27.776 2.559   11.234  1.00 28.76 ? 620 HOH B O   1 
HETATM 4800 O O   . HOH K 4 .   ? 1.546   22.254  -28.568 1.00 25.88 ? 621 HOH B O   1 
HETATM 4801 O O   . HOH K 4 .   ? -5.910  23.151  13.884  1.00 27.08 ? 622 HOH B O   1 
HETATM 4802 O O   . HOH K 4 .   ? 12.038  17.225  -10.322 1.00 27.53 ? 623 HOH B O   1 
HETATM 4803 O O   A HOH K 4 .   ? -8.547  31.405  -1.856  0.67 18.17 ? 624 HOH B O   1 
HETATM 4804 O O   B HOH K 4 .   ? -8.084  33.024  -2.122  0.33 19.09 ? 624 HOH B O   1 
HETATM 4805 O O   . HOH K 4 .   ? -34.086 4.906   -4.440  1.00 36.30 ? 625 HOH B O   1 
HETATM 4806 O O   . HOH K 4 .   ? -19.031 2.817   6.147   1.00 23.75 ? 626 HOH B O   1 
HETATM 4807 O O   . HOH K 4 .   ? -9.051  35.982  -15.433 1.00 15.23 ? 627 HOH B O   1 
HETATM 4808 O O   . HOH K 4 .   ? -3.711  32.780  -23.257 1.00 32.83 ? 628 HOH B O   1 
HETATM 4809 O O   . HOH K 4 .   ? -31.216 17.380  6.839   1.00 38.43 ? 629 HOH B O   1 
HETATM 4810 O O   . HOH K 4 .   ? -34.731 25.580  -20.134 1.00 43.14 ? 630 HOH B O   1 
HETATM 4811 O O   . HOH K 4 .   ? -10.598 6.938   5.648   1.00 23.85 ? 631 HOH B O   1 
HETATM 4812 O O   . HOH K 4 .   ? -0.184  31.176  0.898   1.00 40.18 ? 632 HOH B O   1 
HETATM 4813 O O   . HOH K 4 .   ? -21.168 29.260  -20.986 1.00 21.83 ? 633 HOH B O   1 
HETATM 4814 O O   . HOH K 4 .   ? -18.125 21.521  -28.861 1.00 33.97 ? 634 HOH B O   1 
HETATM 4815 O O   . HOH K 4 .   ? -24.596 16.268  -19.853 1.00 27.03 ? 635 HOH B O   1 
HETATM 4816 O O   . HOH K 4 .   ? 4.486   26.322  -16.788 1.00 30.05 ? 636 HOH B O   1 
HETATM 4817 O O   . HOH K 4 .   ? -18.837 14.372  -16.119 1.00 23.29 ? 637 HOH B O   1 
HETATM 4818 O O   . HOH K 4 .   ? 3.157   17.686  -26.656 1.00 32.61 ? 638 HOH B O   1 
HETATM 4819 O O   . HOH K 4 .   ? -10.971 33.746  -26.258 1.00 38.30 ? 639 HOH B O   1 
HETATM 4820 O O   . HOH K 4 .   ? 6.694   30.713  -21.933 1.00 26.78 ? 640 HOH B O   1 
HETATM 4821 O O   . HOH K 4 .   ? -1.722  34.936  -15.431 1.00 38.94 ? 641 HOH B O   1 
HETATM 4822 O O   . HOH K 4 .   ? 4.988   28.463  -20.447 1.00 25.33 ? 642 HOH B O   1 
HETATM 4823 O O   . HOH K 4 .   ? -27.886 5.152   -7.727  1.00 37.40 ? 643 HOH B O   1 
HETATM 4824 O O   . HOH K 4 .   ? -2.203  10.026  -13.172 1.00 27.03 ? 644 HOH B O   1 
HETATM 4825 O O   . HOH K 4 .   ? -7.812  36.719  0.709   1.00 40.24 ? 645 HOH B O   1 
HETATM 4826 O O   . HOH K 4 .   ? -23.899 16.506  -8.924  1.00 28.37 ? 646 HOH B O   1 
HETATM 4827 O O   . HOH K 4 .   ? -0.722  18.423  -25.393 1.00 21.57 ? 647 HOH B O   1 
HETATM 4828 O O   . HOH K 4 .   ? 3.774   21.175  -0.374  1.00 25.93 ? 648 HOH B O   1 
HETATM 4829 O O   . HOH K 4 .   ? 3.753   30.020  -1.041  1.00 24.07 ? 649 HOH B O   1 
HETATM 4830 O O   . HOH K 4 .   ? -23.462 6.081   14.628  1.00 30.41 ? 650 HOH B O   1 
HETATM 4831 O O   . HOH K 4 .   ? -7.282  38.343  -7.902  1.00 37.53 ? 651 HOH B O   1 
HETATM 4832 O O   . HOH K 4 .   ? 0.126   12.491  1.786   1.00 35.19 ? 652 HOH B O   1 
HETATM 4833 O O   . HOH K 4 .   ? -30.511 27.027  -29.224 1.00 43.76 ? 653 HOH B O   1 
HETATM 4834 O O   . HOH K 4 .   ? -5.203  31.595  1.590   1.00 33.30 ? 654 HOH B O   1 
HETATM 4835 O O   . HOH K 4 .   ? 5.829   30.153  0.722   1.00 27.91 ? 655 HOH B O   1 
HETATM 4836 O O   . HOH K 4 .   ? -14.458 9.470   -20.676 1.00 26.85 ? 656 HOH B O   1 
HETATM 4837 O O   A HOH K 4 .   ? -20.655 30.183  -15.214 0.59 15.41 ? 657 HOH B O   1 
HETATM 4838 O O   B HOH K 4 .   ? -20.440 31.044  -13.769 0.41 18.34 ? 657 HOH B O   1 
HETATM 4839 O O   . HOH K 4 .   ? -0.825  27.006  -28.841 1.00 22.78 ? 658 HOH B O   1 
HETATM 4840 O O   . HOH K 4 .   ? -29.533 10.566  14.885  1.00 42.97 ? 659 HOH B O   1 
HETATM 4841 O O   . HOH K 4 .   ? 6.339   28.813  -13.536 1.00 35.96 ? 660 HOH B O   1 
HETATM 4842 O O   . HOH K 4 .   ? -29.815 21.213  -11.646 1.00 35.45 ? 661 HOH B O   1 
HETATM 4843 O O   . HOH K 4 .   ? 3.164   16.258  0.794   1.00 40.45 ? 662 HOH B O   1 
HETATM 4844 O O   . HOH K 4 .   ? 9.159   30.081  -0.122  1.00 25.62 ? 663 HOH B O   1 
HETATM 4845 O O   . HOH K 4 .   ? 10.985  19.875  -9.572  1.00 28.31 ? 664 HOH B O   1 
HETATM 4846 O O   . HOH K 4 .   ? -0.896  33.002  -3.332  1.00 31.42 ? 665 HOH B O   1 
HETATM 4847 O O   . HOH K 4 .   ? 11.322  23.626  -2.190  1.00 35.82 ? 666 HOH B O   1 
HETATM 4848 O O   . HOH K 4 .   ? -7.047  28.911  -36.713 1.00 28.67 ? 667 HOH B O   1 
HETATM 4849 O O   . HOH K 4 .   ? -20.644 35.686  -1.612  1.00 20.12 ? 668 HOH B O   1 
HETATM 4850 O O   . HOH K 4 .   ? -27.544 30.429  7.305   1.00 28.27 ? 669 HOH B O   1 
HETATM 4851 O O   . HOH K 4 .   ? -19.900 9.339   19.865  1.00 37.31 ? 670 HOH B O   1 
HETATM 4852 O O   . HOH K 4 .   ? -27.934 -3.178  -0.552  1.00 27.39 ? 671 HOH B O   1 
HETATM 4853 O O   . HOH K 4 .   ? -32.130 25.802  -23.080 1.00 41.31 ? 672 HOH B O   1 
HETATM 4854 O O   . HOH K 4 .   ? -16.555 6.605   6.546   1.00 19.39 ? 673 HOH B O   1 
HETATM 4855 O O   . HOH K 4 .   ? 11.797  23.526  -13.732 1.00 30.28 ? 674 HOH B O   1 
HETATM 4856 O O   . HOH K 4 .   ? -24.720 30.925  7.707   1.00 30.00 ? 675 HOH B O   1 
HETATM 4857 O O   . HOH K 4 .   ? -26.495 22.691  12.567  1.00 39.55 ? 676 HOH B O   1 
HETATM 4858 O O   . HOH K 4 .   ? -3.488  28.067  6.996   1.00 31.87 ? 677 HOH B O   1 
HETATM 4859 O O   . HOH K 4 .   ? -37.559 7.696   -1.810  1.00 32.24 ? 678 HOH B O   1 
HETATM 4860 O O   . HOH K 4 .   ? -8.034  7.602   8.054   1.00 39.70 ? 679 HOH B O   1 
HETATM 4861 O O   . HOH K 4 .   ? -4.479  7.130   1.866   1.00 32.20 ? 680 HOH B O   1 
HETATM 4862 O O   . HOH K 4 .   ? -12.142 26.455  -33.762 1.00 30.94 ? 681 HOH B O   1 
HETATM 4863 O O   . HOH K 4 .   ? -15.106 31.236  -23.861 1.00 29.92 ? 682 HOH B O   1 
HETATM 4864 O O   . HOH K 4 .   ? 12.497  18.446  -14.484 1.00 45.56 ? 683 HOH B O   1 
HETATM 4865 O O   . HOH K 4 .   ? -10.111 28.617  10.602  1.00 27.07 ? 684 HOH B O   1 
HETATM 4866 O O   . HOH K 4 .   ? -32.704 27.778  -16.442 1.00 29.72 ? 685 HOH B O   1 
HETATM 4867 O O   . HOH K 4 .   ? -6.284  11.019  -22.393 1.00 37.98 ? 686 HOH B O   1 
HETATM 4868 O O   A HOH K 4 .   ? -18.805 25.639  10.852  0.57 15.68 ? 687 HOH B O   1 
HETATM 4869 O O   B HOH K 4 .   ? -17.728 26.836  11.018  0.43 20.38 ? 687 HOH B O   1 
HETATM 4870 O O   . HOH K 4 .   ? -31.210 16.485  3.358   1.00 29.06 ? 688 HOH B O   1 
HETATM 4871 O O   . HOH K 4 .   ? -31.885 26.009  -14.717 1.00 19.56 ? 689 HOH B O   1 
HETATM 4872 O O   . HOH K 4 .   ? -11.094 38.099  -14.942 1.00 27.94 ? 690 HOH B O   1 
HETATM 4873 O O   . HOH K 4 .   ? -6.039  28.360  -31.778 1.00 34.71 ? 691 HOH B O   1 
HETATM 4874 O O   . HOH K 4 .   ? -1.674  15.006  5.198   1.00 28.10 ? 692 HOH B O   1 
HETATM 4875 O O   . HOH K 4 .   ? -0.035  34.776  -10.494 1.00 40.55 ? 693 HOH B O   1 
HETATM 4876 O O   . HOH K 4 .   ? -33.682 6.032   12.002  1.00 40.42 ? 694 HOH B O   1 
HETATM 4877 O O   . HOH K 4 .   ? -5.761  30.175  -29.827 1.00 33.01 ? 695 HOH B O   1 
HETATM 4878 O O   A HOH K 4 .   ? 1.877   32.055  -16.709 0.59 28.71 ? 696 HOH B O   1 
HETATM 4879 O O   B HOH K 4 .   ? 2.239   30.059  -17.728 0.41 18.58 ? 696 HOH B O   1 
HETATM 4880 O O   . HOH K 4 .   ? -19.997 -0.799  -1.601  1.00 23.23 ? 697 HOH B O   1 
HETATM 4881 O O   . HOH K 4 .   ? -19.264 5.790   0.576   1.00 12.46 ? 698 HOH B O   1 
HETATM 4882 O O   . HOH K 4 .   ? -15.624 24.791  13.658  1.00 18.34 ? 699 HOH B O   1 
HETATM 4883 O O   . HOH K 4 .   ? -13.119 11.277  -21.914 1.00 28.33 ? 700 HOH B O   1 
HETATM 4884 O O   . HOH K 4 .   ? -10.102 13.550  11.149  1.00 25.11 ? 701 HOH B O   1 
HETATM 4885 O O   . HOH K 4 .   ? 11.240  23.767  -11.111 1.00 20.23 ? 702 HOH B O   1 
HETATM 4886 O O   . HOH K 4 .   ? -15.427 37.157  -16.573 1.00 25.46 ? 703 HOH B O   1 
HETATM 4887 O O   . HOH K 4 .   ? 4.916   34.599  -19.444 1.00 29.42 ? 704 HOH B O   1 
HETATM 4888 O O   . HOH K 4 .   ? -34.515 18.062  5.332   1.00 44.72 ? 705 HOH B O   1 
HETATM 4889 O O   . HOH K 4 .   ? -14.331 34.952  8.722   1.00 26.96 ? 706 HOH B O   1 
HETATM 4890 O O   B HOH K 4 .   ? 4.978   31.680  -26.506 0.93 34.52 ? 707 HOH B O   1 
HETATM 4891 O O   . HOH K 4 .   ? -29.455 0.227   -3.733  1.00 27.39 ? 708 HOH B O   1 
HETATM 4892 O O   . HOH K 4 .   ? -26.527 -0.797  5.985   1.00 27.18 ? 709 HOH B O   1 
HETATM 4893 O O   . HOH K 4 .   ? -33.393 2.114   -5.887  1.00 34.66 ? 710 HOH B O   1 
HETATM 4894 O O   . HOH K 4 .   ? 12.116  27.383  -2.863  1.00 14.31 ? 711 HOH B O   1 
HETATM 4895 O O   . HOH K 4 .   ? -8.191  31.939  -28.507 1.00 33.13 ? 712 HOH B O   1 
HETATM 4896 O O   . HOH K 4 .   ? -6.345  27.311  12.355  1.00 26.30 ? 713 HOH B O   1 
HETATM 4897 O O   . HOH K 4 .   ? -8.951  36.950  4.142   1.00 32.86 ? 714 HOH B O   1 
HETATM 4898 O O   . HOH K 4 .   ? -2.756  6.778   -5.551  1.00 33.35 ? 715 HOH B O   1 
HETATM 4899 O O   . HOH K 4 .   ? -7.926  35.507  -20.448 1.00 37.37 ? 716 HOH B O   1 
HETATM 4900 O O   . HOH K 4 .   ? 11.027  21.276  -4.170  1.00 20.73 ? 717 HOH B O   1 
HETATM 4901 O O   . HOH K 4 .   ? -8.259  34.829  -5.508  1.00 27.45 ? 718 HOH B O   1 
HETATM 4902 O O   . HOH K 4 .   ? -17.571 23.195  -30.820 1.00 41.58 ? 719 HOH B O   1 
HETATM 4903 O O   . HOH K 4 .   ? 2.949   1.826   -15.610 1.00 44.10 ? 720 HOH B O   1 
HETATM 4904 O O   . HOH K 4 .   ? 9.868   27.045  -1.232  1.00 25.11 ? 721 HOH B O   1 
HETATM 4905 O O   . HOH K 4 .   ? -32.975 27.903  -20.330 1.00 40.99 ? 722 HOH B O   1 
HETATM 4906 O O   A HOH K 4 .   ? -31.473 20.083  2.117   0.54 16.39 ? 723 HOH B O   1 
HETATM 4907 O O   B HOH K 4 .   ? -30.921 18.834  3.791   0.46 23.61 ? 723 HOH B O   1 
HETATM 4908 O O   . HOH K 4 .   ? -34.128 17.568  -0.797  1.00 35.38 ? 724 HOH B O   1 
HETATM 4909 O O   . HOH K 4 .   ? -4.191  34.019  -20.851 1.00 27.06 ? 725 HOH B O   1 
HETATM 4910 O O   . HOH K 4 .   ? -19.543 3.116   -0.121  1.00 18.22 ? 726 HOH B O   1 
HETATM 4911 O O   . HOH K 4 .   ? 9.552   27.513  -13.742 1.00 38.75 ? 727 HOH B O   1 
HETATM 4912 O O   . HOH K 4 .   ? -20.552 36.555  -11.951 1.00 25.04 ? 728 HOH B O   1 
HETATM 4913 O O   . HOH K 4 .   ? -29.277 23.194  4.303   1.00 14.05 ? 729 HOH B O   1 
HETATM 4914 O O   . HOH K 4 .   ? -11.074 5.960   3.039   1.00 29.13 ? 730 HOH B O   1 
HETATM 4915 O O   . HOH K 4 .   ? -20.228 38.318  -9.640  1.00 41.59 ? 731 HOH B O   1 
HETATM 4916 O O   . HOH K 4 .   ? 2.081   29.560  1.275   1.00 29.77 ? 732 HOH B O   1 
HETATM 4917 O O   . HOH K 4 .   ? -11.149 29.381  -36.533 1.00 30.77 ? 733 HOH B O   1 
HETATM 4918 O O   . HOH K 4 .   ? -11.682 37.326  -7.709  1.00 36.05 ? 734 HOH B O   1 
HETATM 4919 O O   . HOH K 4 .   ? -10.928 27.418  13.668  1.00 39.41 ? 735 HOH B O   1 
HETATM 4920 O O   A HOH K 4 .   ? -6.636  29.165  8.020   0.62 21.20 ? 736 HOH B O   1 
HETATM 4921 O O   B HOH K 4 .   ? -5.782  28.735  5.916   0.38 20.35 ? 736 HOH B O   1 
HETATM 4922 O O   . HOH K 4 .   ? -29.435 16.957  9.006   1.00 18.69 ? 737 HOH B O   1 
HETATM 4923 O O   . HOH K 4 .   ? 1.648   17.282  3.611   1.00 35.38 ? 738 HOH B O   1 
HETATM 4924 O O   . HOH K 4 .   ? -30.260 23.405  6.827   1.00 19.43 ? 739 HOH B O   1 
HETATM 4925 O O   . HOH K 4 .   ? -6.532  25.504  15.109  1.00 43.83 ? 740 HOH B O   1 
HETATM 4926 O O   . HOH K 4 .   ? -17.891 30.674  -23.863 1.00 31.05 ? 741 HOH B O   1 
HETATM 4927 O O   . HOH K 4 .   ? -31.184 26.238  0.589   1.00 22.59 ? 742 HOH B O   1 
HETATM 4928 O O   . HOH K 4 .   ? 12.260  15.812  -12.834 1.00 42.34 ? 743 HOH B O   1 
HETATM 4929 O O   . HOH K 4 .   ? -15.895 4.389   2.767   1.00 18.79 ? 744 HOH B O   1 
HETATM 4930 O O   . HOH K 4 .   ? -32.326 21.506  -10.656 1.00 33.81 ? 745 HOH B O   1 
HETATM 4931 O O   . HOH K 4 .   ? -22.377 39.315  -8.361  1.00 34.03 ? 746 HOH B O   1 
HETATM 4932 O O   . HOH K 4 .   ? -13.296 4.858   3.463   1.00 34.40 ? 747 HOH B O   1 
HETATM 4933 O O   . HOH K 4 .   ? -34.884 4.212   -2.103  1.00 27.53 ? 748 HOH B O   1 
HETATM 4934 O O   . HOH K 4 .   ? 4.698   25.456  -14.035 1.00 39.18 ? 749 HOH B O   1 
HETATM 4935 O O   . HOH K 4 .   ? -30.857 37.868  -11.823 1.00 30.28 ? 750 HOH B O   1 
HETATM 4936 O O   . HOH K 4 .   ? -16.662 5.685   9.092   1.00 17.86 ? 751 HOH B O   1 
HETATM 4937 O O   . HOH K 4 .   ? -8.958  12.108  -22.829 1.00 16.02 ? 752 HOH B O   1 
HETATM 4938 O O   . HOH K 4 .   ? -32.458 29.736  -1.776  1.00 13.14 ? 753 HOH B O   1 
HETATM 4939 O O   . HOH K 4 .   ? -17.293 2.244   1.089   1.00 25.88 ? 754 HOH B O   1 
HETATM 4940 O O   . HOH K 4 .   ? -11.612 25.199  15.724  1.00 24.12 ? 755 HOH B O   1 
HETATM 4941 O O   . HOH K 4 .   ? 6.394   26.090  -21.742 1.00 39.69 ? 756 HOH B O   1 
HETATM 4942 O O   . HOH K 4 .   ? -21.282 2.007   -5.004  1.00 24.23 ? 757 HOH B O   1 
HETATM 4943 O O   . HOH K 4 .   ? 12.343  27.485  -12.683 1.00 19.93 ? 758 HOH B O   1 
HETATM 4944 O O   . HOH K 4 .   ? -29.787 25.036  11.087  1.00 34.56 ? 759 HOH B O   1 
HETATM 4945 O O   . HOH K 4 .   ? -12.268 2.917   1.272   1.00 25.88 ? 760 HOH B O   1 
HETATM 4946 O O   . HOH K 4 .   ? -3.789  10.498  10.544  1.00 26.35 ? 761 HOH B O   1 
HETATM 4947 O O   . HOH K 4 .   ? -34.853 23.305  0.081   1.00 39.52 ? 762 HOH B O   1 
HETATM 4948 O O   . HOH K 4 .   ? -1.505  12.808  4.074   1.00 26.05 ? 763 HOH B O   1 
HETATM 4949 O O   . HOH K 4 .   ? -17.778 4.929   4.610   1.00 14.47 ? 764 HOH B O   1 
HETATM 4950 O O   . HOH K 4 .   ? -41.258 8.723   4.285   1.00 35.86 ? 765 HOH B O   1 
HETATM 4951 O O   . HOH K 4 .   ? -13.059 33.456  11.368  1.00 38.08 ? 766 HOH B O   1 
HETATM 4952 O O   . HOH K 4 .   ? -18.283 37.492  -12.895 1.00 27.82 ? 767 HOH B O   1 
HETATM 4953 O O   . HOH K 4 .   ? 3.806   19.042  1.055   1.00 37.41 ? 768 HOH B O   1 
HETATM 4954 O O   . HOH K 4 .   ? 1.449   24.619  13.828  1.00 53.16 ? 769 HOH B O   1 
HETATM 4955 O O   . HOH K 4 .   ? -4.935  27.157  -35.847 1.00 32.21 ? 770 HOH B O   1 
HETATM 4956 O O   . HOH K 4 .   ? -30.987 24.936  2.966   1.00 17.01 ? 771 HOH B O   1 
HETATM 4957 O O   . HOH K 4 .   ? -12.868 27.949  11.483  1.00 29.22 ? 772 HOH B O   1 
HETATM 4958 O O   . HOH K 4 .   ? -3.784  27.268  -32.958 1.00 32.49 ? 773 HOH B O   1 
HETATM 4959 O O   . HOH K 4 .   ? -34.508 25.729  0.968   1.00 28.54 ? 774 HOH B O   1 
HETATM 4960 O O   . HOH K 4 .   ? -32.993 20.737  4.136   1.00 32.82 ? 775 HOH B O   1 
# 
