data_9OHL
# 
_entry.id   9OHL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9OHL         pdb_00009ohl 10.2210/pdb9ohl/pdb 
WWPDB D_1000295275 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-11 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
2 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9OHL 
_pdbx_database_status.recvd_initial_deposition_date   2025-05-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              steffenb@vividion.com 
_pdbx_contact_author.name_first         Steffen 
_pdbx_contact_author.name_last          Bernard 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8061-6136 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Goetzke, F.W.' 1 ? 
'Bernard, S.M.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2025.05.25.655995 
_citation.pdbx_database_id_PubMed   40475643 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Goetzke, F.W.'   1  ? 
primary 'Bernard, S.M.'   2  ? 
primary 'Ju, C.W.'        3  ? 
primary 'Pollock, J.'     4  ? 
primary 'DeMeester, K.E.' 5  ? 
primary 'Gross, J.'       6  ? 
primary 'Simon, G.M.'     7  ? 
primary 'He, C.'          8  ? 
primary 'Melillo, B.'     9  ? 
primary 'Cravatt, B.F.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'rRNA N(6)-adenosine-methyltransferase METTL5'                                                                
23752.543 1   2.1.1.- ? ? ? 
2 polymer     man 'Multifunctional methyltransferase subunit TRM112-like protein'                                               
14215.359 1   ?       ? ? ? 
3 non-polymer syn S-ADENOSYLMETHIONINE                                                                                          
398.437   1   ?       ? ? ? 
4 non-polymer syn 'N-(4-{[(3aS,4R,6S,6aR)-6-(3-chlorophenyl)-2-propanoyloctahydrocyclopenta[c]pyrrol-4-yl]oxy}phenyl)acetamide' 
426.936   1   ?       ? ? ? 
5 non-polymer nat GLYCEROL                                                                                                      
92.094    1   ?       ? ? ? 
6 water       nat water                                                                                                         
18.015    452 ?       ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Methyltransferase-like protein 5'   
2 'tRNA methyltransferase 112 homolog' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGF
DIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSS
TREHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFSF
;
;MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGF
DIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSS
TREHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFSF
;
C ? 
2 'polypeptide(L)' no no 
;MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEF
LRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES
;
;MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEF
LRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES
;
D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 S-ADENOSYLMETHIONINE                                                                                          SAM   
4 'N-(4-{[(3aS,4R,6S,6aR)-6-(3-chlorophenyl)-2-propanoyloctahydrocyclopenta[c]pyrrol-4-yl]oxy}phenyl)acetamide' A1CBE 
5 GLYCEROL                                                                                                      GOL   
6 water                                                                                                         HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   LYS n 
1 4   VAL n 
1 5   ARG n 
1 6   LEU n 
1 7   LYS n 
1 8   GLU n 
1 9   LEU n 
1 10  GLU n 
1 11  SER n 
1 12  ARG n 
1 13  LEU n 
1 14  GLN n 
1 15  GLN n 
1 16  VAL n 
1 17  ASP n 
1 18  GLY n 
1 19  PHE n 
1 20  GLU n 
1 21  LYS n 
1 22  PRO n 
1 23  LYS n 
1 24  LEU n 
1 25  LEU n 
1 26  LEU n 
1 27  GLU n 
1 28  GLN n 
1 29  TYR n 
1 30  PRO n 
1 31  THR n 
1 32  ARG n 
1 33  PRO n 
1 34  HIS n 
1 35  ILE n 
1 36  ALA n 
1 37  ALA n 
1 38  CYS n 
1 39  MET n 
1 40  LEU n 
1 41  TYR n 
1 42  THR n 
1 43  ILE n 
1 44  HIS n 
1 45  ASN n 
1 46  THR n 
1 47  TYR n 
1 48  ASP n 
1 49  ASP n 
1 50  ILE n 
1 51  GLU n 
1 52  ASN n 
1 53  LYS n 
1 54  VAL n 
1 55  VAL n 
1 56  ALA n 
1 57  ASP n 
1 58  LEU n 
1 59  GLY n 
1 60  CYS n 
1 61  GLY n 
1 62  CYS n 
1 63  GLY n 
1 64  VAL n 
1 65  LEU n 
1 66  SER n 
1 67  ILE n 
1 68  GLY n 
1 69  THR n 
1 70  ALA n 
1 71  MET n 
1 72  LEU n 
1 73  GLY n 
1 74  ALA n 
1 75  GLY n 
1 76  LEU n 
1 77  CYS n 
1 78  VAL n 
1 79  GLY n 
1 80  PHE n 
1 81  ASP n 
1 82  ILE n 
1 83  ASP n 
1 84  GLU n 
1 85  ASP n 
1 86  ALA n 
1 87  LEU n 
1 88  GLU n 
1 89  ILE n 
1 90  PHE n 
1 91  ASN n 
1 92  ARG n 
1 93  ASN n 
1 94  ALA n 
1 95  GLU n 
1 96  GLU n 
1 97  PHE n 
1 98  GLU n 
1 99  LEU n 
1 100 THR n 
1 101 ASN n 
1 102 ILE n 
1 103 ASP n 
1 104 MET n 
1 105 VAL n 
1 106 GLN n 
1 107 CYS n 
1 108 ASP n 
1 109 VAL n 
1 110 CYS n 
1 111 LEU n 
1 112 LEU n 
1 113 SER n 
1 114 ASN n 
1 115 ARG n 
1 116 MET n 
1 117 SER n 
1 118 LYS n 
1 119 SER n 
1 120 PHE n 
1 121 ASP n 
1 122 THR n 
1 123 VAL n 
1 124 ILE n 
1 125 MET n 
1 126 ASN n 
1 127 PRO n 
1 128 PRO n 
1 129 PHE n 
1 130 GLY n 
1 131 THR n 
1 132 LYS n 
1 133 ASN n 
1 134 ASN n 
1 135 LYS n 
1 136 GLY n 
1 137 THR n 
1 138 ASP n 
1 139 MET n 
1 140 ALA n 
1 141 PHE n 
1 142 LEU n 
1 143 LYS n 
1 144 THR n 
1 145 ALA n 
1 146 LEU n 
1 147 GLU n 
1 148 MET n 
1 149 ALA n 
1 150 ARG n 
1 151 THR n 
1 152 ALA n 
1 153 VAL n 
1 154 TYR n 
1 155 SER n 
1 156 LEU n 
1 157 HIS n 
1 158 LYS n 
1 159 SER n 
1 160 SER n 
1 161 THR n 
1 162 ARG n 
1 163 GLU n 
1 164 HIS n 
1 165 VAL n 
1 166 GLN n 
1 167 LYS n 
1 168 LYS n 
1 169 ALA n 
1 170 ALA n 
1 171 GLU n 
1 172 TRP n 
1 173 LYS n 
1 174 ILE n 
1 175 LYS n 
1 176 ILE n 
1 177 ASP n 
1 178 ILE n 
1 179 ILE n 
1 180 ALA n 
1 181 GLU n 
1 182 LEU n 
1 183 ARG n 
1 184 TYR n 
1 185 ASP n 
1 186 LEU n 
1 187 PRO n 
1 188 ALA n 
1 189 SER n 
1 190 TYR n 
1 191 LYS n 
1 192 PHE n 
1 193 HIS n 
1 194 LYS n 
1 195 LYS n 
1 196 LYS n 
1 197 SER n 
1 198 VAL n 
1 199 ASP n 
1 200 ILE n 
1 201 GLU n 
1 202 VAL n 
1 203 ASP n 
1 204 LEU n 
1 205 ILE n 
1 206 ARG n 
1 207 PHE n 
1 208 SER n 
1 209 PHE n 
2 1   MET n 
2 2   LYS n 
2 3   LEU n 
2 4   LEU n 
2 5   THR n 
2 6   HIS n 
2 7   ASN n 
2 8   LEU n 
2 9   LEU n 
2 10  SER n 
2 11  SER n 
2 12  HIS n 
2 13  VAL n 
2 14  ARG n 
2 15  GLY n 
2 16  VAL n 
2 17  GLY n 
2 18  SER n 
2 19  ARG n 
2 20  GLY n 
2 21  PHE n 
2 22  PRO n 
2 23  LEU n 
2 24  ARG n 
2 25  LEU n 
2 26  GLN n 
2 27  ALA n 
2 28  THR n 
2 29  GLU n 
2 30  VAL n 
2 31  ARG n 
2 32  ILE n 
2 33  CYS n 
2 34  PRO n 
2 35  VAL n 
2 36  GLU n 
2 37  PHE n 
2 38  ASN n 
2 39  PRO n 
2 40  ASN n 
2 41  PHE n 
2 42  VAL n 
2 43  ALA n 
2 44  ARG n 
2 45  MET n 
2 46  ILE n 
2 47  PRO n 
2 48  LYS n 
2 49  VAL n 
2 50  GLU n 
2 51  TRP n 
2 52  SER n 
2 53  ALA n 
2 54  PHE n 
2 55  LEU n 
2 56  GLU n 
2 57  ALA n 
2 58  ALA n 
2 59  ASP n 
2 60  ASN n 
2 61  LEU n 
2 62  ARG n 
2 63  LEU n 
2 64  ILE n 
2 65  GLN n 
2 66  VAL n 
2 67  PRO n 
2 68  LYS n 
2 69  GLY n 
2 70  PRO n 
2 71  VAL n 
2 72  GLU n 
2 73  GLY n 
2 74  TYR n 
2 75  GLU n 
2 76  GLU n 
2 77  ASN n 
2 78  GLU n 
2 79  GLU n 
2 80  PHE n 
2 81  LEU n 
2 82  ARG n 
2 83  THR n 
2 84  MET n 
2 85  HIS n 
2 86  HIS n 
2 87  LEU n 
2 88  LEU n 
2 89  LEU n 
2 90  GLU n 
2 91  VAL n 
2 92  GLU n 
2 93  VAL n 
2 94  ILE n 
2 95  GLU n 
2 96  GLY n 
2 97  THR n 
2 98  LEU n 
2 99  GLN n 
2 100 CYS n 
2 101 PRO n 
2 102 GLU n 
2 103 SER n 
2 104 GLY n 
2 105 ARG n 
2 106 MET n 
2 107 PHE n 
2 108 PRO n 
2 109 ILE n 
2 110 SER n 
2 111 ARG n 
2 112 GLY n 
2 113 ILE n 
2 114 PRO n 
2 115 ASN n 
2 116 MET n 
2 117 LEU n 
2 118 LEU n 
2 119 SER n 
2 120 GLU n 
2 121 GLU n 
2 122 GLU n 
2 123 THR n 
2 124 GLU n 
2 125 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 209 human ? 'METTL5, DC3, HSPC133'              ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 125 human ? 'TRMT112, AD-001, HSPC152, HSPC170' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1CBE non-polymer         . 
'N-(4-{[(3aS,4R,6S,6aR)-6-(3-chlorophenyl)-2-propanoyloctahydrocyclopenta[c]pyrrol-4-yl]oxy}phenyl)acetamide' ? 'C24 H27 Cl N2 O3' 
426.936 
ALA   'L-peptide linking' y ALANINE ?                               'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE ?                               'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE ?                               'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE ?                               'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE ?                               'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE ?                               'C2 H5 N O2'       75.067  
GOL   non-polymer         . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'         92.094  
HIS   'L-peptide linking' y HISTIDINE ?                               'C6 H10 N3 O2 1'   156.162 
HOH   non-polymer         . WATER ?                               'H2 O'             18.015  
ILE   'L-peptide linking' y ISOLEUCINE ?                               'C6 H13 N O2'      131.173 
LEU   'L-peptide linking' y LEUCINE ?                               'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE ?                               'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE ?                               'C5 H11 N O2 S'    149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?                               'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE ?                               'C5 H9 N O2'       115.130 
SAM   non-polymer         . S-ADENOSYLMETHIONINE ?                               'C15 H22 N6 O5 S'  398.437 
SER   'L-peptide linking' y SERINE ?                               'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE ?                               'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?                               'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE ?                               'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE ?                               'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   C . n 
A 1 2   LYS 2   2   ?   ?   ?   C . n 
A 1 3   LYS 3   3   3   LYS LYS C . n 
A 1 4   VAL 4   4   4   VAL VAL C . n 
A 1 5   ARG 5   5   5   ARG ARG C . n 
A 1 6   LEU 6   6   6   LEU LEU C . n 
A 1 7   LYS 7   7   7   LYS LYS C . n 
A 1 8   GLU 8   8   8   GLU GLU C . n 
A 1 9   LEU 9   9   9   LEU LEU C . n 
A 1 10  GLU 10  10  10  GLU GLU C . n 
A 1 11  SER 11  11  11  SER SER C . n 
A 1 12  ARG 12  12  12  ARG ARG C . n 
A 1 13  LEU 13  13  13  LEU LEU C . n 
A 1 14  GLN 14  14  14  GLN GLN C . n 
A 1 15  GLN 15  15  15  GLN GLN C . n 
A 1 16  VAL 16  16  16  VAL VAL C . n 
A 1 17  ASP 17  17  17  ASP ASP C . n 
A 1 18  GLY 18  18  18  GLY GLY C . n 
A 1 19  PHE 19  19  19  PHE PHE C . n 
A 1 20  GLU 20  20  20  GLU GLU C . n 
A 1 21  LYS 21  21  21  LYS LYS C . n 
A 1 22  PRO 22  22  22  PRO PRO C . n 
A 1 23  LYS 23  23  23  LYS LYS C . n 
A 1 24  LEU 24  24  24  LEU LEU C . n 
A 1 25  LEU 25  25  25  LEU LEU C . n 
A 1 26  LEU 26  26  26  LEU LEU C . n 
A 1 27  GLU 27  27  27  GLU GLU C . n 
A 1 28  GLN 28  28  28  GLN GLN C . n 
A 1 29  TYR 29  29  29  TYR TYR C . n 
A 1 30  PRO 30  30  30  PRO PRO C . n 
A 1 31  THR 31  31  31  THR THR C . n 
A 1 32  ARG 32  32  32  ARG ARG C . n 
A 1 33  PRO 33  33  33  PRO PRO C . n 
A 1 34  HIS 34  34  34  HIS HIS C . n 
A 1 35  ILE 35  35  35  ILE ILE C . n 
A 1 36  ALA 36  36  36  ALA ALA C . n 
A 1 37  ALA 37  37  37  ALA ALA C . n 
A 1 38  CYS 38  38  38  CYS CYS C . n 
A 1 39  MET 39  39  39  MET MET C . n 
A 1 40  LEU 40  40  40  LEU LEU C . n 
A 1 41  TYR 41  41  41  TYR TYR C . n 
A 1 42  THR 42  42  42  THR THR C . n 
A 1 43  ILE 43  43  43  ILE ILE C . n 
A 1 44  HIS 44  44  44  HIS HIS C . n 
A 1 45  ASN 45  45  45  ASN ASN C . n 
A 1 46  THR 46  46  46  THR THR C . n 
A 1 47  TYR 47  47  47  TYR TYR C . n 
A 1 48  ASP 48  48  48  ASP ASP C . n 
A 1 49  ASP 49  49  49  ASP ASP C . n 
A 1 50  ILE 50  50  50  ILE ILE C . n 
A 1 51  GLU 51  51  51  GLU GLU C . n 
A 1 52  ASN 52  52  52  ASN ASN C . n 
A 1 53  LYS 53  53  53  LYS LYS C . n 
A 1 54  VAL 54  54  54  VAL VAL C . n 
A 1 55  VAL 55  55  55  VAL VAL C . n 
A 1 56  ALA 56  56  56  ALA ALA C . n 
A 1 57  ASP 57  57  57  ASP ASP C . n 
A 1 58  LEU 58  58  58  LEU LEU C . n 
A 1 59  GLY 59  59  59  GLY GLY C . n 
A 1 60  CYS 60  60  60  CYS CYS C . n 
A 1 61  GLY 61  61  61  GLY GLY C . n 
A 1 62  CYS 62  62  62  CYS CYS C . n 
A 1 63  GLY 63  63  63  GLY GLY C . n 
A 1 64  VAL 64  64  64  VAL VAL C . n 
A 1 65  LEU 65  65  65  LEU LEU C . n 
A 1 66  SER 66  66  66  SER SER C . n 
A 1 67  ILE 67  67  67  ILE ILE C . n 
A 1 68  GLY 68  68  68  GLY GLY C . n 
A 1 69  THR 69  69  69  THR THR C . n 
A 1 70  ALA 70  70  70  ALA ALA C . n 
A 1 71  MET 71  71  71  MET MET C . n 
A 1 72  LEU 72  72  72  LEU LEU C . n 
A 1 73  GLY 73  73  73  GLY GLY C . n 
A 1 74  ALA 74  74  74  ALA ALA C . n 
A 1 75  GLY 75  75  75  GLY GLY C . n 
A 1 76  LEU 76  76  76  LEU LEU C . n 
A 1 77  CYS 77  77  77  CYS CYS C . n 
A 1 78  VAL 78  78  78  VAL VAL C . n 
A 1 79  GLY 79  79  79  GLY GLY C . n 
A 1 80  PHE 80  80  80  PHE PHE C . n 
A 1 81  ASP 81  81  81  ASP ASP C . n 
A 1 82  ILE 82  82  82  ILE ILE C . n 
A 1 83  ASP 83  83  83  ASP ASP C . n 
A 1 84  GLU 84  84  84  GLU GLU C . n 
A 1 85  ASP 85  85  85  ASP ASP C . n 
A 1 86  ALA 86  86  86  ALA ALA C . n 
A 1 87  LEU 87  87  87  LEU LEU C . n 
A 1 88  GLU 88  88  88  GLU GLU C . n 
A 1 89  ILE 89  89  89  ILE ILE C . n 
A 1 90  PHE 90  90  90  PHE PHE C . n 
A 1 91  ASN 91  91  91  ASN ASN C . n 
A 1 92  ARG 92  92  92  ARG ARG C . n 
A 1 93  ASN 93  93  93  ASN ASN C . n 
A 1 94  ALA 94  94  94  ALA ALA C . n 
A 1 95  GLU 95  95  95  GLU GLU C . n 
A 1 96  GLU 96  96  96  GLU GLU C . n 
A 1 97  PHE 97  97  97  PHE PHE C . n 
A 1 98  GLU 98  98  98  GLU GLU C . n 
A 1 99  LEU 99  99  99  LEU LEU C . n 
A 1 100 THR 100 100 100 THR THR C . n 
A 1 101 ASN 101 101 101 ASN ASN C . n 
A 1 102 ILE 102 102 102 ILE ILE C . n 
A 1 103 ASP 103 103 103 ASP ASP C . n 
A 1 104 MET 104 104 104 MET MET C . n 
A 1 105 VAL 105 105 105 VAL VAL C . n 
A 1 106 GLN 106 106 106 GLN GLN C . n 
A 1 107 CYS 107 107 107 CYS CYS C . n 
A 1 108 ASP 108 108 108 ASP ASP C . n 
A 1 109 VAL 109 109 109 VAL VAL C . n 
A 1 110 CYS 110 110 110 CYS CYS C . n 
A 1 111 LEU 111 111 111 LEU LEU C . n 
A 1 112 LEU 112 112 112 LEU LEU C . n 
A 1 113 SER 113 113 113 SER SER C . n 
A 1 114 ASN 114 114 114 ASN ASN C . n 
A 1 115 ARG 115 115 115 ARG ARG C . n 
A 1 116 MET 116 116 116 MET MET C . n 
A 1 117 SER 117 117 117 SER SER C . n 
A 1 118 LYS 118 118 118 LYS LYS C . n 
A 1 119 SER 119 119 119 SER SER C . n 
A 1 120 PHE 120 120 120 PHE PHE C . n 
A 1 121 ASP 121 121 121 ASP ASP C . n 
A 1 122 THR 122 122 122 THR THR C . n 
A 1 123 VAL 123 123 123 VAL VAL C . n 
A 1 124 ILE 124 124 124 ILE ILE C . n 
A 1 125 MET 125 125 125 MET MET C . n 
A 1 126 ASN 126 126 126 ASN ASN C . n 
A 1 127 PRO 127 127 127 PRO PRO C . n 
A 1 128 PRO 128 128 128 PRO PRO C . n 
A 1 129 PHE 129 129 129 PHE PHE C . n 
A 1 130 GLY 130 130 130 GLY GLY C . n 
A 1 131 THR 131 131 131 THR THR C . n 
A 1 132 LYS 132 132 132 LYS LYS C . n 
A 1 133 ASN 133 133 133 ASN ASN C . n 
A 1 134 ASN 134 134 134 ASN ASN C . n 
A 1 135 LYS 135 135 135 LYS LYS C . n 
A 1 136 GLY 136 136 136 GLY GLY C . n 
A 1 137 THR 137 137 137 THR THR C . n 
A 1 138 ASP 138 138 138 ASP ASP C . n 
A 1 139 MET 139 139 139 MET MET C . n 
A 1 140 ALA 140 140 140 ALA ALA C . n 
A 1 141 PHE 141 141 141 PHE PHE C . n 
A 1 142 LEU 142 142 142 LEU LEU C . n 
A 1 143 LYS 143 143 143 LYS LYS C . n 
A 1 144 THR 144 144 144 THR THR C . n 
A 1 145 ALA 145 145 145 ALA ALA C . n 
A 1 146 LEU 146 146 146 LEU LEU C . n 
A 1 147 GLU 147 147 147 GLU GLU C . n 
A 1 148 MET 148 148 148 MET MET C . n 
A 1 149 ALA 149 149 149 ALA ALA C . n 
A 1 150 ARG 150 150 150 ARG ARG C . n 
A 1 151 THR 151 151 151 THR THR C . n 
A 1 152 ALA 152 152 152 ALA ALA C . n 
A 1 153 VAL 153 153 153 VAL VAL C . n 
A 1 154 TYR 154 154 154 TYR TYR C . n 
A 1 155 SER 155 155 155 SER SER C . n 
A 1 156 LEU 156 156 156 LEU LEU C . n 
A 1 157 HIS 157 157 157 HIS HIS C . n 
A 1 158 LYS 158 158 158 LYS LYS C . n 
A 1 159 SER 159 159 159 SER SER C . n 
A 1 160 SER 160 160 160 SER SER C . n 
A 1 161 THR 161 161 161 THR THR C . n 
A 1 162 ARG 162 162 162 ARG ARG C . n 
A 1 163 GLU 163 163 163 GLU GLU C . n 
A 1 164 HIS 164 164 164 HIS HIS C . n 
A 1 165 VAL 165 165 165 VAL VAL C . n 
A 1 166 GLN 166 166 166 GLN GLN C . n 
A 1 167 LYS 167 167 167 LYS LYS C . n 
A 1 168 LYS 168 168 168 LYS LYS C . n 
A 1 169 ALA 169 169 169 ALA ALA C . n 
A 1 170 ALA 170 170 170 ALA ALA C . n 
A 1 171 GLU 171 171 171 GLU GLU C . n 
A 1 172 TRP 172 172 172 TRP TRP C . n 
A 1 173 LYS 173 173 173 LYS LYS C . n 
A 1 174 ILE 174 174 174 ILE ILE C . n 
A 1 175 LYS 175 175 175 LYS LYS C . n 
A 1 176 ILE 176 176 176 ILE ILE C . n 
A 1 177 ASP 177 177 177 ASP ASP C . n 
A 1 178 ILE 178 178 178 ILE ILE C . n 
A 1 179 ILE 179 179 179 ILE ILE C . n 
A 1 180 ALA 180 180 180 ALA ALA C . n 
A 1 181 GLU 181 181 181 GLU GLU C . n 
A 1 182 LEU 182 182 182 LEU LEU C . n 
A 1 183 ARG 183 183 183 ARG ARG C . n 
A 1 184 TYR 184 184 184 TYR TYR C . n 
A 1 185 ASP 185 185 185 ASP ASP C . n 
A 1 186 LEU 186 186 186 LEU LEU C . n 
A 1 187 PRO 187 187 187 PRO PRO C . n 
A 1 188 ALA 188 188 188 ALA ALA C . n 
A 1 189 SER 189 189 189 SER SER C . n 
A 1 190 TYR 190 190 190 TYR TYR C . n 
A 1 191 LYS 191 191 191 LYS LYS C . n 
A 1 192 PHE 192 192 192 PHE PHE C . n 
A 1 193 HIS 193 193 193 HIS HIS C . n 
A 1 194 LYS 194 194 194 LYS LYS C . n 
A 1 195 LYS 195 195 195 LYS LYS C . n 
A 1 196 LYS 196 196 196 LYS LYS C . n 
A 1 197 SER 197 197 197 SER SER C . n 
A 1 198 VAL 198 198 198 VAL VAL C . n 
A 1 199 ASP 199 199 199 ASP ASP C . n 
A 1 200 ILE 200 200 200 ILE ILE C . n 
A 1 201 GLU 201 201 201 GLU GLU C . n 
A 1 202 VAL 202 202 202 VAL VAL C . n 
A 1 203 ASP 203 203 203 ASP ASP C . n 
A 1 204 LEU 204 204 204 LEU LEU C . n 
A 1 205 ILE 205 205 205 ILE ILE C . n 
A 1 206 ARG 206 206 206 ARG ARG C . n 
A 1 207 PHE 207 207 207 PHE PHE C . n 
A 1 208 SER 208 208 208 SER SER C . n 
A 1 209 PHE 209 209 209 PHE PHE C . n 
B 2 1   MET 1   1   1   MET MET D . n 
B 2 2   LYS 2   2   2   LYS LYS D . n 
B 2 3   LEU 3   3   3   LEU LEU D . n 
B 2 4   LEU 4   4   4   LEU LEU D . n 
B 2 5   THR 5   5   5   THR THR D . n 
B 2 6   HIS 6   6   6   HIS HIS D . n 
B 2 7   ASN 7   7   7   ASN ASN D . n 
B 2 8   LEU 8   8   8   LEU LEU D . n 
B 2 9   LEU 9   9   9   LEU LEU D . n 
B 2 10  SER 10  10  10  SER SER D . n 
B 2 11  SER 11  11  11  SER SER D . n 
B 2 12  HIS 12  12  12  HIS HIS D . n 
B 2 13  VAL 13  13  13  VAL VAL D . n 
B 2 14  ARG 14  14  14  ARG ARG D . n 
B 2 15  GLY 15  15  15  GLY GLY D . n 
B 2 16  VAL 16  16  16  VAL VAL D . n 
B 2 17  GLY 17  17  17  GLY GLY D . n 
B 2 18  SER 18  18  18  SER SER D . n 
B 2 19  ARG 19  19  19  ARG ARG D . n 
B 2 20  GLY 20  20  20  GLY GLY D . n 
B 2 21  PHE 21  21  21  PHE PHE D . n 
B 2 22  PRO 22  22  22  PRO PRO D . n 
B 2 23  LEU 23  23  23  LEU LEU D . n 
B 2 24  ARG 24  24  24  ARG ARG D . n 
B 2 25  LEU 25  25  25  LEU LEU D . n 
B 2 26  GLN 26  26  26  GLN GLN D . n 
B 2 27  ALA 27  27  27  ALA ALA D . n 
B 2 28  THR 28  28  28  THR THR D . n 
B 2 29  GLU 29  29  29  GLU GLU D . n 
B 2 30  VAL 30  30  30  VAL VAL D . n 
B 2 31  ARG 31  31  31  ARG ARG D . n 
B 2 32  ILE 32  32  32  ILE ILE D . n 
B 2 33  CYS 33  33  33  CYS CYS D . n 
B 2 34  PRO 34  34  34  PRO PRO D . n 
B 2 35  VAL 35  35  35  VAL VAL D . n 
B 2 36  GLU 36  36  36  GLU GLU D . n 
B 2 37  PHE 37  37  37  PHE PHE D . n 
B 2 38  ASN 38  38  38  ASN ASN D . n 
B 2 39  PRO 39  39  39  PRO PRO D . n 
B 2 40  ASN 40  40  40  ASN ASN D . n 
B 2 41  PHE 41  41  41  PHE PHE D . n 
B 2 42  VAL 42  42  42  VAL VAL D . n 
B 2 43  ALA 43  43  43  ALA ALA D . n 
B 2 44  ARG 44  44  44  ARG ARG D . n 
B 2 45  MET 45  45  45  MET MET D . n 
B 2 46  ILE 46  46  46  ILE ILE D . n 
B 2 47  PRO 47  47  47  PRO PRO D . n 
B 2 48  LYS 48  48  48  LYS LYS D . n 
B 2 49  VAL 49  49  49  VAL VAL D . n 
B 2 50  GLU 50  50  50  GLU GLU D . n 
B 2 51  TRP 51  51  51  TRP TRP D . n 
B 2 52  SER 52  52  52  SER SER D . n 
B 2 53  ALA 53  53  53  ALA ALA D . n 
B 2 54  PHE 54  54  54  PHE PHE D . n 
B 2 55  LEU 55  55  55  LEU LEU D . n 
B 2 56  GLU 56  56  56  GLU GLU D . n 
B 2 57  ALA 57  57  57  ALA ALA D . n 
B 2 58  ALA 58  58  58  ALA ALA D . n 
B 2 59  ASP 59  59  59  ASP ASP D . n 
B 2 60  ASN 60  60  60  ASN ASN D . n 
B 2 61  LEU 61  61  61  LEU LEU D . n 
B 2 62  ARG 62  62  62  ARG ARG D . n 
B 2 63  LEU 63  63  63  LEU LEU D . n 
B 2 64  ILE 64  64  64  ILE ILE D . n 
B 2 65  GLN 65  65  65  GLN GLN D . n 
B 2 66  VAL 66  66  66  VAL VAL D . n 
B 2 67  PRO 67  67  67  PRO PRO D . n 
B 2 68  LYS 68  68  68  LYS LYS D . n 
B 2 69  GLY 69  69  69  GLY GLY D . n 
B 2 70  PRO 70  70  70  PRO PRO D . n 
B 2 71  VAL 71  71  71  VAL VAL D . n 
B 2 72  GLU 72  72  72  GLU GLU D . n 
B 2 73  GLY 73  73  73  GLY GLY D . n 
B 2 74  TYR 74  74  74  TYR TYR D . n 
B 2 75  GLU 75  75  75  GLU GLU D . n 
B 2 76  GLU 76  76  76  GLU GLU D . n 
B 2 77  ASN 77  77  77  ASN ASN D . n 
B 2 78  GLU 78  78  78  GLU GLU D . n 
B 2 79  GLU 79  79  79  GLU GLU D . n 
B 2 80  PHE 80  80  80  PHE PHE D . n 
B 2 81  LEU 81  81  81  LEU LEU D . n 
B 2 82  ARG 82  82  82  ARG ARG D . n 
B 2 83  THR 83  83  83  THR THR D . n 
B 2 84  MET 84  84  84  MET MET D . n 
B 2 85  HIS 85  85  85  HIS HIS D . n 
B 2 86  HIS 86  86  86  HIS HIS D . n 
B 2 87  LEU 87  87  87  LEU LEU D . n 
B 2 88  LEU 88  88  88  LEU LEU D . n 
B 2 89  LEU 89  89  89  LEU LEU D . n 
B 2 90  GLU 90  90  90  GLU GLU D . n 
B 2 91  VAL 91  91  91  VAL VAL D . n 
B 2 92  GLU 92  92  92  GLU GLU D . n 
B 2 93  VAL 93  93  93  VAL VAL D . n 
B 2 94  ILE 94  94  94  ILE ILE D . n 
B 2 95  GLU 95  95  95  GLU GLU D . n 
B 2 96  GLY 96  96  96  GLY GLY D . n 
B 2 97  THR 97  97  97  THR THR D . n 
B 2 98  LEU 98  98  98  LEU LEU D . n 
B 2 99  GLN 99  99  99  GLN GLN D . n 
B 2 100 CYS 100 100 100 CYS CYS D . n 
B 2 101 PRO 101 101 101 PRO PRO D . n 
B 2 102 GLU 102 102 102 GLU GLU D . n 
B 2 103 SER 103 103 103 SER SER D . n 
B 2 104 GLY 104 104 104 GLY GLY D . n 
B 2 105 ARG 105 105 105 ARG ARG D . n 
B 2 106 MET 106 106 106 MET MET D . n 
B 2 107 PHE 107 107 107 PHE PHE D . n 
B 2 108 PRO 108 108 108 PRO PRO D . n 
B 2 109 ILE 109 109 109 ILE ILE D . n 
B 2 110 SER 110 110 110 SER SER D . n 
B 2 111 ARG 111 111 111 ARG ARG D . n 
B 2 112 GLY 112 112 112 GLY GLY D . n 
B 2 113 ILE 113 113 113 ILE ILE D . n 
B 2 114 PRO 114 114 114 PRO PRO D . n 
B 2 115 ASN 115 115 115 ASN ASN D . n 
B 2 116 MET 116 116 116 MET MET D . n 
B 2 117 LEU 117 117 117 LEU LEU D . n 
B 2 118 LEU 118 118 118 LEU LEU D . n 
B 2 119 SER 119 119 119 SER SER D . n 
B 2 120 GLU 120 120 ?   ?   ?   D . n 
B 2 121 GLU 121 121 ?   ?   ?   D . n 
B 2 122 GLU 122 122 ?   ?   ?   D . n 
B 2 123 THR 123 123 ?   ?   ?   D . n 
B 2 124 GLU 124 124 ?   ?   ?   D . n 
B 2 125 SER 125 125 ?   ?   ?   D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1CBE 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1CBE 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 SAM   1   301 301 SAM   SAM C . 
D 4 A1CBE 1   201 201 A1CBE 33B D . 
E 5 GOL   1   202 202 GOL   GOL D . 
F 6 HOH   1   401 186 HOH   HOH C . 
F 6 HOH   2   402 250 HOH   HOH C . 
F 6 HOH   3   403 119 HOH   HOH C . 
F 6 HOH   4   404 245 HOH   HOH C . 
F 6 HOH   5   405 253 HOH   HOH C . 
F 6 HOH   6   406 260 HOH   HOH C . 
F 6 HOH   7   407 398 HOH   HOH C . 
F 6 HOH   8   408 353 HOH   HOH C . 
F 6 HOH   9   409 432 HOH   HOH C . 
F 6 HOH   10  410 451 HOH   HOH C . 
F 6 HOH   11  411 227 HOH   HOH C . 
F 6 HOH   12  412 242 HOH   HOH C . 
F 6 HOH   13  413 372 HOH   HOH C . 
F 6 HOH   14  414 246 HOH   HOH C . 
F 6 HOH   15  415 59  HOH   HOH C . 
F 6 HOH   16  416 265 HOH   HOH C . 
F 6 HOH   17  417 235 HOH   HOH C . 
F 6 HOH   18  418 220 HOH   HOH C . 
F 6 HOH   19  419 255 HOH   HOH C . 
F 6 HOH   20  420 142 HOH   HOH C . 
F 6 HOH   21  421 328 HOH   HOH C . 
F 6 HOH   22  422 351 HOH   HOH C . 
F 6 HOH   23  423 348 HOH   HOH C . 
F 6 HOH   24  424 144 HOH   HOH C . 
F 6 HOH   25  425 213 HOH   HOH C . 
F 6 HOH   26  426 234 HOH   HOH C . 
F 6 HOH   27  427 63  HOH   HOH C . 
F 6 HOH   28  428 394 HOH   HOH C . 
F 6 HOH   29  429 404 HOH   HOH C . 
F 6 HOH   30  430 256 HOH   HOH C . 
F 6 HOH   31  431 342 HOH   HOH C . 
F 6 HOH   32  432 201 HOH   HOH C . 
F 6 HOH   33  433 67  HOH   HOH C . 
F 6 HOH   34  434 361 HOH   HOH C . 
F 6 HOH   35  435 196 HOH   HOH C . 
F 6 HOH   36  436 360 HOH   HOH C . 
F 6 HOH   37  437 240 HOH   HOH C . 
F 6 HOH   38  438 337 HOH   HOH C . 
F 6 HOH   39  439 295 HOH   HOH C . 
F 6 HOH   40  440 310 HOH   HOH C . 
F 6 HOH   41  441 251 HOH   HOH C . 
F 6 HOH   42  442 104 HOH   HOH C . 
F 6 HOH   43  443 191 HOH   HOH C . 
F 6 HOH   44  444 106 HOH   HOH C . 
F 6 HOH   45  445 262 HOH   HOH C . 
F 6 HOH   46  446 42  HOH   HOH C . 
F 6 HOH   47  447 314 HOH   HOH C . 
F 6 HOH   48  448 371 HOH   HOH C . 
F 6 HOH   49  449 19  HOH   HOH C . 
F 6 HOH   50  450 81  HOH   HOH C . 
F 6 HOH   51  451 215 HOH   HOH C . 
F 6 HOH   52  452 95  HOH   HOH C . 
F 6 HOH   53  453 267 HOH   HOH C . 
F 6 HOH   54  454 53  HOH   HOH C . 
F 6 HOH   55  455 321 HOH   HOH C . 
F 6 HOH   56  456 325 HOH   HOH C . 
F 6 HOH   57  457 327 HOH   HOH C . 
F 6 HOH   58  458 399 HOH   HOH C . 
F 6 HOH   59  459 131 HOH   HOH C . 
F 6 HOH   60  460 128 HOH   HOH C . 
F 6 HOH   61  461 263 HOH   HOH C . 
F 6 HOH   62  462 71  HOH   HOH C . 
F 6 HOH   63  463 64  HOH   HOH C . 
F 6 HOH   64  464 307 HOH   HOH C . 
F 6 HOH   65  465 375 HOH   HOH C . 
F 6 HOH   66  466 302 HOH   HOH C . 
F 6 HOH   67  467 150 HOH   HOH C . 
F 6 HOH   68  468 288 HOH   HOH C . 
F 6 HOH   69  469 29  HOH   HOH C . 
F 6 HOH   70  470 96  HOH   HOH C . 
F 6 HOH   71  471 34  HOH   HOH C . 
F 6 HOH   72  472 280 HOH   HOH C . 
F 6 HOH   73  473 357 HOH   HOH C . 
F 6 HOH   74  474 290 HOH   HOH C . 
F 6 HOH   75  475 3   HOH   HOH C . 
F 6 HOH   76  476 147 HOH   HOH C . 
F 6 HOH   77  477 299 HOH   HOH C . 
F 6 HOH   78  478 188 HOH   HOH C . 
F 6 HOH   79  479 13  HOH   HOH C . 
F 6 HOH   80  480 33  HOH   HOH C . 
F 6 HOH   81  481 355 HOH   HOH C . 
F 6 HOH   82  482 46  HOH   HOH C . 
F 6 HOH   83  483 311 HOH   HOH C . 
F 6 HOH   84  484 30  HOH   HOH C . 
F 6 HOH   85  485 75  HOH   HOH C . 
F 6 HOH   86  486 145 HOH   HOH C . 
F 6 HOH   87  487 16  HOH   HOH C . 
F 6 HOH   88  488 212 HOH   HOH C . 
F 6 HOH   89  489 289 HOH   HOH C . 
F 6 HOH   90  490 434 HOH   HOH C . 
F 6 HOH   91  491 102 HOH   HOH C . 
F 6 HOH   92  492 115 HOH   HOH C . 
F 6 HOH   93  493 92  HOH   HOH C . 
F 6 HOH   94  494 324 HOH   HOH C . 
F 6 HOH   95  495 354 HOH   HOH C . 
F 6 HOH   96  496 183 HOH   HOH C . 
F 6 HOH   97  497 198 HOH   HOH C . 
F 6 HOH   98  498 350 HOH   HOH C . 
F 6 HOH   99  499 441 HOH   HOH C . 
F 6 HOH   100 500 331 HOH   HOH C . 
F 6 HOH   101 501 32  HOH   HOH C . 
F 6 HOH   102 502 14  HOH   HOH C . 
F 6 HOH   103 503 356 HOH   HOH C . 
F 6 HOH   104 504 400 HOH   HOH C . 
F 6 HOH   105 505 313 HOH   HOH C . 
F 6 HOH   106 506 11  HOH   HOH C . 
F 6 HOH   107 507 88  HOH   HOH C . 
F 6 HOH   108 508 249 HOH   HOH C . 
F 6 HOH   109 509 315 HOH   HOH C . 
F 6 HOH   110 510 151 HOH   HOH C . 
F 6 HOH   111 511 182 HOH   HOH C . 
F 6 HOH   112 512 148 HOH   HOH C . 
F 6 HOH   113 513 296 HOH   HOH C . 
F 6 HOH   114 514 238 HOH   HOH C . 
F 6 HOH   115 515 113 HOH   HOH C . 
F 6 HOH   116 516 9   HOH   HOH C . 
F 6 HOH   117 517 36  HOH   HOH C . 
F 6 HOH   118 518 80  HOH   HOH C . 
F 6 HOH   119 519 38  HOH   HOH C . 
F 6 HOH   120 520 156 HOH   HOH C . 
F 6 HOH   121 521 179 HOH   HOH C . 
F 6 HOH   122 522 373 HOH   HOH C . 
F 6 HOH   123 523 333 HOH   HOH C . 
F 6 HOH   124 524 57  HOH   HOH C . 
F 6 HOH   125 525 431 HOH   HOH C . 
F 6 HOH   126 526 297 HOH   HOH C . 
F 6 HOH   127 527 208 HOH   HOH C . 
F 6 HOH   128 528 76  HOH   HOH C . 
F 6 HOH   129 529 283 HOH   HOH C . 
F 6 HOH   130 530 118 HOH   HOH C . 
F 6 HOH   131 531 319 HOH   HOH C . 
F 6 HOH   132 532 10  HOH   HOH C . 
F 6 HOH   133 533 120 HOH   HOH C . 
F 6 HOH   134 534 54  HOH   HOH C . 
F 6 HOH   135 535 149 HOH   HOH C . 
F 6 HOH   136 536 291 HOH   HOH C . 
F 6 HOH   137 537 108 HOH   HOH C . 
F 6 HOH   138 538 82  HOH   HOH C . 
F 6 HOH   139 539 305 HOH   HOH C . 
F 6 HOH   140 540 52  HOH   HOH C . 
F 6 HOH   141 541 312 HOH   HOH C . 
F 6 HOH   142 542 22  HOH   HOH C . 
F 6 HOH   143 543 336 HOH   HOH C . 
F 6 HOH   144 544 200 HOH   HOH C . 
F 6 HOH   145 545 56  HOH   HOH C . 
F 6 HOH   146 546 45  HOH   HOH C . 
F 6 HOH   147 547 341 HOH   HOH C . 
F 6 HOH   148 548 443 HOH   HOH C . 
F 6 HOH   149 549 266 HOH   HOH C . 
F 6 HOH   150 550 329 HOH   HOH C . 
F 6 HOH   151 551 181 HOH   HOH C . 
F 6 HOH   152 552 239 HOH   HOH C . 
F 6 HOH   153 553 62  HOH   HOH C . 
F 6 HOH   154 554 24  HOH   HOH C . 
F 6 HOH   155 555 309 HOH   HOH C . 
F 6 HOH   156 556 439 HOH   HOH C . 
F 6 HOH   157 557 284 HOH   HOH C . 
F 6 HOH   158 558 58  HOH   HOH C . 
F 6 HOH   159 559 376 HOH   HOH C . 
F 6 HOH   160 560 137 HOH   HOH C . 
F 6 HOH   161 561 380 HOH   HOH C . 
F 6 HOH   162 562 237 HOH   HOH C . 
F 6 HOH   163 563 121 HOH   HOH C . 
F 6 HOH   164 564 367 HOH   HOH C . 
F 6 HOH   165 565 318 HOH   HOH C . 
F 6 HOH   166 566 35  HOH   HOH C . 
F 6 HOH   167 567 322 HOH   HOH C . 
F 6 HOH   168 568 55  HOH   HOH C . 
F 6 HOH   169 569 199 HOH   HOH C . 
F 6 HOH   170 570 4   HOH   HOH C . 
F 6 HOH   171 571 86  HOH   HOH C . 
F 6 HOH   172 572 264 HOH   HOH C . 
F 6 HOH   173 573 369 HOH   HOH C . 
F 6 HOH   174 574 116 HOH   HOH C . 
F 6 HOH   175 575 269 HOH   HOH C . 
F 6 HOH   176 576 252 HOH   HOH C . 
F 6 HOH   177 577 445 HOH   HOH C . 
F 6 HOH   178 578 165 HOH   HOH C . 
F 6 HOH   179 579 180 HOH   HOH C . 
F 6 HOH   180 580 51  HOH   HOH C . 
F 6 HOH   181 581 93  HOH   HOH C . 
F 6 HOH   182 582 192 HOH   HOH C . 
F 6 HOH   183 583 422 HOH   HOH C . 
F 6 HOH   184 584 389 HOH   HOH C . 
F 6 HOH   185 585 123 HOH   HOH C . 
F 6 HOH   186 586 395 HOH   HOH C . 
F 6 HOH   187 587 332 HOH   HOH C . 
F 6 HOH   188 588 218 HOH   HOH C . 
F 6 HOH   189 589 85  HOH   HOH C . 
F 6 HOH   190 590 401 HOH   HOH C . 
F 6 HOH   191 591 204 HOH   HOH C . 
F 6 HOH   192 592 105 HOH   HOH C . 
F 6 HOH   193 593 428 HOH   HOH C . 
F 6 HOH   194 594 44  HOH   HOH C . 
F 6 HOH   195 595 258 HOH   HOH C . 
F 6 HOH   196 596 418 HOH   HOH C . 
F 6 HOH   197 597 160 HOH   HOH C . 
F 6 HOH   198 598 226 HOH   HOH C . 
F 6 HOH   199 599 424 HOH   HOH C . 
F 6 HOH   200 600 157 HOH   HOH C . 
F 6 HOH   201 601 370 HOH   HOH C . 
F 6 HOH   202 602 134 HOH   HOH C . 
F 6 HOH   203 603 171 HOH   HOH C . 
F 6 HOH   204 604 347 HOH   HOH C . 
F 6 HOH   205 605 230 HOH   HOH C . 
F 6 HOH   206 606 440 HOH   HOH C . 
F 6 HOH   207 607 60  HOH   HOH C . 
F 6 HOH   208 608 167 HOH   HOH C . 
F 6 HOH   209 609 386 HOH   HOH C . 
F 6 HOH   210 610 197 HOH   HOH C . 
F 6 HOH   211 611 344 HOH   HOH C . 
F 6 HOH   212 612 40  HOH   HOH C . 
F 6 HOH   213 613 259 HOH   HOH C . 
F 6 HOH   214 614 277 HOH   HOH C . 
F 6 HOH   215 615 187 HOH   HOH C . 
F 6 HOH   216 616 408 HOH   HOH C . 
F 6 HOH   217 617 72  HOH   HOH C . 
F 6 HOH   218 618 184 HOH   HOH C . 
F 6 HOH   219 619 430 HOH   HOH C . 
F 6 HOH   220 620 416 HOH   HOH C . 
F 6 HOH   221 621 109 HOH   HOH C . 
F 6 HOH   222 622 228 HOH   HOH C . 
F 6 HOH   223 623 415 HOH   HOH C . 
F 6 HOH   224 624 112 HOH   HOH C . 
F 6 HOH   225 625 396 HOH   HOH C . 
F 6 HOH   226 626 158 HOH   HOH C . 
F 6 HOH   227 627 406 HOH   HOH C . 
F 6 HOH   228 628 17  HOH   HOH C . 
F 6 HOH   229 629 326 HOH   HOH C . 
F 6 HOH   230 630 129 HOH   HOH C . 
F 6 HOH   231 631 135 HOH   HOH C . 
F 6 HOH   232 632 366 HOH   HOH C . 
F 6 HOH   233 633 195 HOH   HOH C . 
F 6 HOH   234 634 114 HOH   HOH C . 
F 6 HOH   235 635 335 HOH   HOH C . 
F 6 HOH   236 636 49  HOH   HOH C . 
F 6 HOH   237 637 423 HOH   HOH C . 
F 6 HOH   238 638 338 HOH   HOH C . 
F 6 HOH   239 639 91  HOH   HOH C . 
F 6 HOH   240 640 379 HOH   HOH C . 
F 6 HOH   241 641 210 HOH   HOH C . 
F 6 HOH   242 642 65  HOH   HOH C . 
F 6 HOH   243 643 155 HOH   HOH C . 
F 6 HOH   244 644 450 HOH   HOH C . 
F 6 HOH   245 645 77  HOH   HOH C . 
F 6 HOH   246 646 126 HOH   HOH C . 
F 6 HOH   247 647 448 HOH   HOH C . 
F 6 HOH   248 648 413 HOH   HOH C . 
F 6 HOH   249 649 346 HOH   HOH C . 
F 6 HOH   250 650 419 HOH   HOH C . 
F 6 HOH   251 651 203 HOH   HOH C . 
F 6 HOH   252 652 103 HOH   HOH C . 
F 6 HOH   253 653 153 HOH   HOH C . 
F 6 HOH   254 654 409 HOH   HOH C . 
F 6 HOH   255 655 444 HOH   HOH C . 
F 6 HOH   256 656 447 HOH   HOH C . 
F 6 HOH   257 657 169 HOH   HOH C . 
F 6 HOH   258 658 206 HOH   HOH C . 
F 6 HOH   259 659 73  HOH   HOH C . 
F 6 HOH   260 660 185 HOH   HOH C . 
F 6 HOH   261 661 233 HOH   HOH C . 
F 6 HOH   262 662 388 HOH   HOH C . 
F 6 HOH   263 663 224 HOH   HOH C . 
F 6 HOH   264 664 402 HOH   HOH C . 
F 6 HOH   265 665 70  HOH   HOH C . 
F 6 HOH   266 666 133 HOH   HOH C . 
F 6 HOH   267 667 98  HOH   HOH C . 
F 6 HOH   268 668 278 HOH   HOH C . 
F 6 HOH   269 669 363 HOH   HOH C . 
F 6 HOH   270 670 174 HOH   HOH C . 
F 6 HOH   271 671 334 HOH   HOH C . 
F 6 HOH   272 672 83  HOH   HOH C . 
F 6 HOH   273 673 268 HOH   HOH C . 
F 6 HOH   274 674 97  HOH   HOH C . 
F 6 HOH   275 675 232 HOH   HOH C . 
F 6 HOH   276 676 449 HOH   HOH C . 
F 6 HOH   277 677 207 HOH   HOH C . 
F 6 HOH   278 678 164 HOH   HOH C . 
G 6 HOH   1   301 410 HOH   HOH D . 
G 6 HOH   2   302 359 HOH   HOH D . 
G 6 HOH   3   303 194 HOH   HOH D . 
G 6 HOH   4   304 257 HOH   HOH D . 
G 6 HOH   5   305 436 HOH   HOH D . 
G 6 HOH   6   306 231 HOH   HOH D . 
G 6 HOH   7   307 437 HOH   HOH D . 
G 6 HOH   8   308 349 HOH   HOH D . 
G 6 HOH   9   309 159 HOH   HOH D . 
G 6 HOH   10  310 270 HOH   HOH D . 
G 6 HOH   11  311 385 HOH   HOH D . 
G 6 HOH   12  312 261 HOH   HOH D . 
G 6 HOH   13  313 219 HOH   HOH D . 
G 6 HOH   14  314 247 HOH   HOH D . 
G 6 HOH   15  315 374 HOH   HOH D . 
G 6 HOH   16  316 214 HOH   HOH D . 
G 6 HOH   17  317 282 HOH   HOH D . 
G 6 HOH   18  318 50  HOH   HOH D . 
G 6 HOH   19  319 1   HOH   HOH D . 
G 6 HOH   20  320 193 HOH   HOH D . 
G 6 HOH   21  321 254 HOH   HOH D . 
G 6 HOH   22  322 387 HOH   HOH D . 
G 6 HOH   23  323 8   HOH   HOH D . 
G 6 HOH   24  324 384 HOH   HOH D . 
G 6 HOH   25  325 39  HOH   HOH D . 
G 6 HOH   26  326 110 HOH   HOH D . 
G 6 HOH   27  327 178 HOH   HOH D . 
G 6 HOH   28  328 377 HOH   HOH D . 
G 6 HOH   29  329 61  HOH   HOH D . 
G 6 HOH   30  330 5   HOH   HOH D . 
G 6 HOH   31  331 298 HOH   HOH D . 
G 6 HOH   32  332 12  HOH   HOH D . 
G 6 HOH   33  333 28  HOH   HOH D . 
G 6 HOH   34  334 393 HOH   HOH D . 
G 6 HOH   35  335 26  HOH   HOH D . 
G 6 HOH   36  336 48  HOH   HOH D . 
G 6 HOH   37  337 225 HOH   HOH D . 
G 6 HOH   38  338 391 HOH   HOH D . 
G 6 HOH   39  339 21  HOH   HOH D . 
G 6 HOH   40  340 211 HOH   HOH D . 
G 6 HOH   41  341 306 HOH   HOH D . 
G 6 HOH   42  342 287 HOH   HOH D . 
G 6 HOH   43  343 316 HOH   HOH D . 
G 6 HOH   44  344 236 HOH   HOH D . 
G 6 HOH   45  345 130 HOH   HOH D . 
G 6 HOH   46  346 15  HOH   HOH D . 
G 6 HOH   47  347 364 HOH   HOH D . 
G 6 HOH   48  348 358 HOH   HOH D . 
G 6 HOH   49  349 90  HOH   HOH D . 
G 6 HOH   50  350 308 HOH   HOH D . 
G 6 HOH   51  351 383 HOH   HOH D . 
G 6 HOH   52  352 292 HOH   HOH D . 
G 6 HOH   53  353 25  HOH   HOH D . 
G 6 HOH   54  354 381 HOH   HOH D . 
G 6 HOH   55  355 293 HOH   HOH D . 
G 6 HOH   56  356 111 HOH   HOH D . 
G 6 HOH   57  357 79  HOH   HOH D . 
G 6 HOH   58  358 27  HOH   HOH D . 
G 6 HOH   59  359 20  HOH   HOH D . 
G 6 HOH   60  360 323 HOH   HOH D . 
G 6 HOH   61  361 31  HOH   HOH D . 
G 6 HOH   62  362 18  HOH   HOH D . 
G 6 HOH   63  363 285 HOH   HOH D . 
G 6 HOH   64  364 244 HOH   HOH D . 
G 6 HOH   65  365 162 HOH   HOH D . 
G 6 HOH   66  366 320 HOH   HOH D . 
G 6 HOH   67  367 176 HOH   HOH D . 
G 6 HOH   68  368 222 HOH   HOH D . 
G 6 HOH   69  369 68  HOH   HOH D . 
G 6 HOH   70  370 303 HOH   HOH D . 
G 6 HOH   71  371 43  HOH   HOH D . 
G 6 HOH   72  372 143 HOH   HOH D . 
G 6 HOH   73  373 190 HOH   HOH D . 
G 6 HOH   74  374 189 HOH   HOH D . 
G 6 HOH   75  375 304 HOH   HOH D . 
G 6 HOH   76  376 66  HOH   HOH D . 
G 6 HOH   77  377 125 HOH   HOH D . 
G 6 HOH   78  378 132 HOH   HOH D . 
G 6 HOH   79  379 23  HOH   HOH D . 
G 6 HOH   80  380 243 HOH   HOH D . 
G 6 HOH   81  381 47  HOH   HOH D . 
G 6 HOH   82  382 301 HOH   HOH D . 
G 6 HOH   83  383 37  HOH   HOH D . 
G 6 HOH   84  384 390 HOH   HOH D . 
G 6 HOH   85  385 317 HOH   HOH D . 
G 6 HOH   86  386 382 HOH   HOH D . 
G 6 HOH   87  387 294 HOH   HOH D . 
G 6 HOH   88  388 433 HOH   HOH D . 
G 6 HOH   89  389 286 HOH   HOH D . 
G 6 HOH   90  390 345 HOH   HOH D . 
G 6 HOH   91  391 122 HOH   HOH D . 
G 6 HOH   92  392 139 HOH   HOH D . 
G 6 HOH   93  393 7   HOH   HOH D . 
G 6 HOH   94  394 100 HOH   HOH D . 
G 6 HOH   95  395 6   HOH   HOH D . 
G 6 HOH   96  396 217 HOH   HOH D . 
G 6 HOH   97  397 2   HOH   HOH D . 
G 6 HOH   98  398 300 HOH   HOH D . 
G 6 HOH   99  399 41  HOH   HOH D . 
G 6 HOH   100 400 173 HOH   HOH D . 
G 6 HOH   101 401 425 HOH   HOH D . 
G 6 HOH   102 402 229 HOH   HOH D . 
G 6 HOH   103 403 74  HOH   HOH D . 
G 6 HOH   104 404 146 HOH   HOH D . 
G 6 HOH   105 405 202 HOH   HOH D . 
G 6 HOH   106 406 140 HOH   HOH D . 
G 6 HOH   107 407 221 HOH   HOH D . 
G 6 HOH   108 408 365 HOH   HOH D . 
G 6 HOH   109 409 378 HOH   HOH D . 
G 6 HOH   110 410 368 HOH   HOH D . 
G 6 HOH   111 411 78  HOH   HOH D . 
G 6 HOH   112 412 330 HOH   HOH D . 
G 6 HOH   113 413 352 HOH   HOH D . 
G 6 HOH   114 414 435 HOH   HOH D . 
G 6 HOH   115 415 392 HOH   HOH D . 
G 6 HOH   116 416 339 HOH   HOH D . 
G 6 HOH   117 417 397 HOH   HOH D . 
G 6 HOH   118 418 446 HOH   HOH D . 
G 6 HOH   119 419 223 HOH   HOH D . 
G 6 HOH   120 420 107 HOH   HOH D . 
G 6 HOH   121 421 89  HOH   HOH D . 
G 6 HOH   122 422 405 HOH   HOH D . 
G 6 HOH   123 423 84  HOH   HOH D . 
G 6 HOH   124 424 127 HOH   HOH D . 
G 6 HOH   125 425 152 HOH   HOH D . 
G 6 HOH   126 426 407 HOH   HOH D . 
G 6 HOH   127 427 209 HOH   HOH D . 
G 6 HOH   128 428 248 HOH   HOH D . 
G 6 HOH   129 429 161 HOH   HOH D . 
G 6 HOH   130 430 166 HOH   HOH D . 
G 6 HOH   131 431 272 HOH   HOH D . 
G 6 HOH   132 432 69  HOH   HOH D . 
G 6 HOH   133 433 403 HOH   HOH D . 
G 6 HOH   134 434 429 HOH   HOH D . 
G 6 HOH   135 435 412 HOH   HOH D . 
G 6 HOH   136 436 275 HOH   HOH D . 
G 6 HOH   137 437 274 HOH   HOH D . 
G 6 HOH   138 438 154 HOH   HOH D . 
G 6 HOH   139 439 442 HOH   HOH D . 
G 6 HOH   140 440 168 HOH   HOH D . 
G 6 HOH   141 441 417 HOH   HOH D . 
G 6 HOH   142 442 175 HOH   HOH D . 
G 6 HOH   143 443 362 HOH   HOH D . 
G 6 HOH   144 444 205 HOH   HOH D . 
G 6 HOH   145 445 421 HOH   HOH D . 
G 6 HOH   146 446 177 HOH   HOH D . 
G 6 HOH   147 447 87  HOH   HOH D . 
G 6 HOH   148 448 101 HOH   HOH D . 
G 6 HOH   149 449 411 HOH   HOH D . 
G 6 HOH   150 450 420 HOH   HOH D . 
G 6 HOH   151 451 138 HOH   HOH D . 
G 6 HOH   152 452 124 HOH   HOH D . 
G 6 HOH   153 453 216 HOH   HOH D . 
G 6 HOH   154 454 99  HOH   HOH D . 
G 6 HOH   155 455 343 HOH   HOH D . 
G 6 HOH   156 456 117 HOH   HOH D . 
G 6 HOH   157 457 438 HOH   HOH D . 
G 6 HOH   158 458 94  HOH   HOH D . 
G 6 HOH   159 459 241 HOH   HOH D . 
G 6 HOH   160 460 340 HOH   HOH D . 
G 6 HOH   161 461 414 HOH   HOH D . 
G 6 HOH   162 462 170 HOH   HOH D . 
G 6 HOH   163 463 281 HOH   HOH D . 
G 6 HOH   164 464 452 HOH   HOH D . 
G 6 HOH   165 465 163 HOH   HOH D . 
G 6 HOH   166 466 273 HOH   HOH D . 
G 6 HOH   167 467 136 HOH   HOH D . 
G 6 HOH   168 468 271 HOH   HOH D . 
G 6 HOH   169 469 427 HOH   HOH D . 
G 6 HOH   170 470 141 HOH   HOH D . 
G 6 HOH   171 471 279 HOH   HOH D . 
G 6 HOH   172 472 172 HOH   HOH D . 
G 6 HOH   173 473 276 HOH   HOH D . 
G 6 HOH   174 474 426 HOH   HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0405 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        ? 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9OHL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     56.684 
_cell.length_a_esd                 ? 
_cell.length_b                     70.640 
_cell.length_b_esd                 ? 
_cell.length_c                     84.553 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9OHL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9OHL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.23 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '21% PEG3350, 0.36 M ammonium sulfate, 0.1 M Bis-Tris pH 5.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-11-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000050 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000050 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.2 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9OHL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.286 
_reflns.d_resolution_low                               47.127 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     80248 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           93.2 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.29 
_reflns_shell.d_res_low                                     1.336 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5110 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.333 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.178 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            0.041 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            0.138 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               13.347 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.961 
_refine.correlation_coeff_Fo_to_Fc_free          0.947 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9OHL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.286 
_refine.ls_d_res_low                             47.127 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     80248 
_refine.ls_number_reflns_R_free                  4112 
_refine.ls_number_reflns_R_work                  76136 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    92.409 
_refine.ls_percent_reflns_R_free                 5.124 
_refine.ls_R_factor_all                          0.188 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2174 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1864 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.055 
_refine.pdbx_overall_ESU_R_Free                  0.059 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             0.994 
_refine.overall_SU_ML                            0.041 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.286 
_refine_hist.d_res_low                        47.127 
_refine_hist.number_atoms_solvent             452 
_refine_hist.number_atoms_total               3104 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2589 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         63 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.012  2716 ? r_bond_refined_d               ? ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2629 ? r_bond_other_d                 ? ? ? 
'X-RAY DIFFRACTION' ? 1.749  1.651  3669 ? r_angle_refined_deg            ? ? ? 
'X-RAY DIFFRACTION' ? 0.566  1.573  6066 ? r_angle_other_deg              ? ? ? 
'X-RAY DIFFRACTION' ? 6.490  5.000  326  ? r_dihedral_angle_1_deg         ? ? ? 
'X-RAY DIFFRACTION' ? 10.264 5.000  22   ? r_dihedral_angle_2_deg         ? ? ? 
'X-RAY DIFFRACTION' ? 0.295  5.000  1    ? r_dihedral_angle_other_2_deg   ? ? ? 
'X-RAY DIFFRACTION' ? 13.244 10.000 491  ? r_dihedral_angle_3_deg         ? ? ? 
'X-RAY DIFFRACTION' ? 5.720  10.000 1    ? r_dihedral_angle_other_3_deg   ? ? ? 
'X-RAY DIFFRACTION' ? 17.835 10.000 120  ? r_dihedral_angle_6_deg         ? ? ? 
'X-RAY DIFFRACTION' ? 0.092  0.200  415  ? r_chiral_restr                 ? ? ? 
'X-RAY DIFFRACTION' ? 0.011  0.020  3109 ? r_gen_planes_refined           ? ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  600  ? r_gen_planes_other             ? ? ? 
'X-RAY DIFFRACTION' ? 0.234  0.200  490  ? r_nbd_refined                  ? ? ? 
'X-RAY DIFFRACTION' ? 0.183  0.200  2405 ? r_symmetry_nbd_other           ? ? ? 
'X-RAY DIFFRACTION' ? 0.177  0.200  1335 ? r_nbtor_refined                ? ? ? 
'X-RAY DIFFRACTION' ? 0.079  0.200  1453 ? r_symmetry_nbtor_other         ? ? ? 
'X-RAY DIFFRACTION' ? 0.176  0.200  266  ? r_xyhbond_nbd_refined          ? ? ? 
'X-RAY DIFFRACTION' ? 0.216  0.200  1    ? r_symmetry_xyhbond_nbd_other   ? ? ? 
'X-RAY DIFFRACTION' ? 0.199  0.200  16   ? r_symmetry_nbd_refined         ? ? ? 
'X-RAY DIFFRACTION' ? 0.231  0.200  58   ? r_nbd_other                    ? ? ? 
'X-RAY DIFFRACTION' ? 0.564  0.200  43   ? r_symmetry_xyhbond_nbd_refined ? ? ? 
'X-RAY DIFFRACTION' ? 1.337  1.167  1310 ? r_mcbond_it                    ? ? ? 
'X-RAY DIFFRACTION' ? 1.336  1.167  1310 ? r_mcbond_other                 ? ? ? 
'X-RAY DIFFRACTION' ? 2.028  2.098  1634 ? r_mcangle_it                   ? ? ? 
'X-RAY DIFFRACTION' ? 2.028  2.099  1635 ? r_mcangle_other                ? ? ? 
'X-RAY DIFFRACTION' ? 2.716  1.537  1406 ? r_scbond_it                    ? ? ? 
'X-RAY DIFFRACTION' ? 2.715  1.538  1407 ? r_scbond_other                 ? ? ? 
'X-RAY DIFFRACTION' ? 4.190  2.651  2035 ? r_scangle_it                   ? ? ? 
'X-RAY DIFFRACTION' ? 4.189  2.652  2036 ? r_scangle_other                ? ? ? 
'X-RAY DIFFRACTION' ? 6.298  20.194 3152 ? r_lrange_it                    ? ? ? 
'X-RAY DIFFRACTION' ? 6.017  15.590 2988 ? r_lrange_other                 ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.286 1.319  6332 . 155 3000 49.8263 . 0.344 . . 0.343 . . . . . 0.334 . . . . . 20 . 0.919 0.912 0.352 
'X-RAY DIFFRACTION' 1.319 1.355  6173 . 225 4181 71.3753 . 0.323 . . 0.323 . . . . . 0.308 . . . . . 20 . 0.934 0.930 0.312 
'X-RAY DIFFRACTION' 1.355 1.395  6034 . 253 4800 83.7421 . 0.285 . . 0.283 . . . . . 0.264 . . . . . 20 . 0.950 0.947 0.314 
'X-RAY DIFFRACTION' 1.395 1.437  5862 . 273 5284 94.7970 . 0.248 . . 0.247 . . . . . 0.222 . . . . . 20 . 0.960 0.956 0.261 
'X-RAY DIFFRACTION' 1.437 1.485  5659 . 313 5333 99.7703 . 0.211 . . 0.209 . . . . . 0.180 . . . . . 20 . 0.969 0.958 0.250 
'X-RAY DIFFRACTION' 1.485 1.537  5522 . 294 5202 99.5292 . 0.193 . . 0.193 . . . . . 0.165 . . . . . 20 . 0.974 0.971 0.201 
'X-RAY DIFFRACTION' 1.537 1.595  5283 . 265 4981 99.2996 . 0.184 . . 0.182 . . . . . 0.158 . . . . . 20 . 0.977 0.967 0.220 
'X-RAY DIFFRACTION' 1.595 1.660  5098 . 260 4815 99.5488 . 0.178 . . 0.175 . . . . . 0.156 . . . . . 20 . 0.979 0.966 0.226 
'X-RAY DIFFRACTION' 1.660 1.733  4920 . 241 4658 99.5732 . 0.176 . . 0.174 . . . . . 0.156 . . . . . 20 . 0.979 0.971 0.215 
'X-RAY DIFFRACTION' 1.733 1.818  4720 . 233 4469 99.6186 . 0.171 . . 0.170 . . . . . 0.155 . . . . . 20 . 0.981 0.973 0.199 
'X-RAY DIFFRACTION' 1.818 1.916  4469 . 223 4216 99.3287 . 0.169 . . 0.168 . . . . . 0.157 . . . . . 20 . 0.982 0.976 0.196 
'X-RAY DIFFRACTION' 1.916 2.032  4264 . 221 4019 99.4371 . 0.173 . . 0.171 . . . . . 0.165 . . . . . 20 . 0.983 0.975 0.205 
'X-RAY DIFFRACTION' 2.032 2.172  4011 . 205 3775 99.2271 . 0.185 . . 0.184 . . . . . 0.180 . . . . . 20 . 0.980 0.975 0.212 
'X-RAY DIFFRACTION' 2.172 2.346  3729 . 210 3496 99.3832 . 0.178 . . 0.176 . . . . . 0.177 . . . . . 20 . 0.981 0.966 0.224 
'X-RAY DIFFRACTION' 2.346 2.569  3447 . 198 3228 99.3908 . 0.172 . . 0.170 . . . . . 0.175 . . . . . 20 . 0.981 0.970 0.204 
'X-RAY DIFFRACTION' 2.569 2.871  3129 . 151 2963 99.5206 . 0.174 . . 0.172 . . . . . 0.183 . . . . . 20 . 0.980 0.973 0.203 
'X-RAY DIFFRACTION' 2.871 3.313  2798 . 137 2637 99.1423 . 0.178 . . 0.176 . . . . . 0.193 . . . . . 20 . 0.980 0.969 0.217 
'X-RAY DIFFRACTION' 3.313 4.053  2395 . 110 2260 98.9562 . 0.166 . . 0.165 . . . . . 0.188 . . . . . 20 . 0.983 0.977 0.194 
'X-RAY DIFFRACTION' 4.053 5.710  1873 . 89  1778 99.6797 . 0.178 . . 0.177 . . . . . 0.210 . . . . . 20 . 0.986 0.984 0.195 
'X-RAY DIFFRACTION' 5.710 47.127 1121 . 56  1041 97.8591 . 0.232 . . 0.231 . . . . . 0.267 . . . . . 20 . 0.975 0.972 0.255 
# 
_struct.entry_id                     9OHL 
_struct.title                        'TRMT112-METTL5 bound to SAM and FWG-33B' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9OHL 
_struct_keywords.text            
'tRNA methyltransferase 112 homolog, Methyltransferase-like protein 5, stereoselective probe, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP METL5_HUMAN Q9NRN9 ? 1 
;MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGF
DIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSS
TREHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFSF
;
1 
2 UNP TR112_HUMAN Q9UI30 ? 2 
;MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEF
LRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES
;
1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9OHL C 1 ? 209 ? Q9NRN9 1 ? 209 ? 1 209 
2 2 9OHL D 1 ? 125 ? Q9UI30 1 ? 125 ? 1 125 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3350  ? 
1 MORE         -12   ? 
1 'SSA (A^2)'  15380 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 5   ? GLN A 14  ? ARG C 5   GLN C 14  1 ? 10 
HELX_P HELX_P2  AA2 LYS A 23  ? GLU A 27  ? LYS C 23  GLU C 27  5 ? 5  
HELX_P HELX_P3  AA3 ARG A 32  ? THR A 46  ? ARG C 32  THR C 46  1 ? 15 
HELX_P HELX_P4  AA4 GLY A 63  ? LEU A 72  ? GLY C 63  LEU C 72  1 ? 10 
HELX_P HELX_P5  AA5 ASP A 83  ? PHE A 97  ? ASP C 83  PHE C 97  1 ? 15 
HELX_P HELX_P6  AA6 ASP A 108 ? LEU A 112 ? ASP C 108 LEU C 112 5 ? 5  
HELX_P HELX_P7  AA7 THR A 137 ? MET A 148 ? THR C 137 MET C 148 1 ? 12 
HELX_P HELX_P8  AA8 THR A 161 ? TRP A 172 ? THR C 161 TRP C 172 1 ? 12 
HELX_P HELX_P9  AA9 PRO A 187 ? LYS A 191 ? PRO C 187 LYS C 191 5 ? 5  
HELX_P HELX_P10 AB1 LYS B 2   ? SER B 10  ? LYS D 2   SER D 10  1 ? 9  
HELX_P HELX_P11 AB2 ASN B 38  ? ILE B 46  ? ASN D 38  ILE D 46  1 ? 9  
HELX_P HELX_P12 AB3 PRO B 47  ? VAL B 49  ? PRO D 47  VAL D 49  5 ? 3  
HELX_P HELX_P13 AB4 GLU B 50  ? LEU B 61  ? GLU D 50  LEU D 61  1 ? 12 
HELX_P HELX_P14 AB5 GLY B 73  ? GLU B 76  ? GLY D 73  GLU D 76  5 ? 4  
HELX_P HELX_P15 AB6 ASN B 77  ? GLU B 90  ? ASN D 77  GLU D 90  1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           B 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            100 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           D 
_struct_conn.ptnr2_label_comp_id           A1CBE 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C23 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            D 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             100 
_struct_conn.ptnr2_auth_asym_id            D 
_struct_conn.ptnr2_auth_comp_id            A1CBE 
_struct_conn.ptnr2_auth_seq_id             201 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.785 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1CBE 
_pdbx_modification_feature.label_asym_id                      D 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     B 
_pdbx_modification_feature.modified_residue_label_seq_id      100 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1CBE 
_pdbx_modification_feature.auth_asym_id                       D 
_pdbx_modification_feature.auth_seq_id                        201 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      D 
_pdbx_modification_feature.modified_residue_auth_seq_id       100 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C23 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1CBE 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 102 ? GLN A 106 ? ILE C 102 GLN C 106 
AA1 2 LEU A 76  ? ASP A 81  ? LEU C 76  ASP C 81  
AA1 3 VAL A 54  ? LEU A 58  ? VAL C 54  LEU C 58  
AA1 4 PHE A 120 ? MET A 125 ? PHE C 120 MET C 125 
AA1 5 ALA A 149 ? LYS A 158 ? ALA C 149 LYS C 158 
AA1 6 ASP A 199 ? SER A 208 ? ASP C 199 SER C 208 
AA1 7 LYS A 175 ? ASP A 185 ? LYS C 175 ASP C 185 
AA2 1 THR A 131 ? LYS A 132 ? THR C 131 LYS C 132 
AA2 2 LYS A 135 ? GLY A 136 ? LYS C 135 GLY C 136 
AA3 1 ARG B 24  ? ILE B 32  ? ARG D 24  ILE D 32  
AA3 2 VAL B 91  ? GLN B 99  ? VAL D 91  GLN D 99  
AA3 3 MET B 106 ? SER B 110 ? MET D 106 SER D 110 
AA3 4 ILE B 113 ? PRO B 114 ? ILE D 113 PRO D 114 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ASP A 103 ? O ASP C 103 N GLY A 79  ? N GLY C 79  
AA1 2 3 O VAL A 78  ? O VAL C 78  N VAL A 55  ? N VAL C 55  
AA1 3 4 N ALA A 56  ? N ALA C 56  O ILE A 124 ? O ILE C 124 
AA1 4 5 N VAL A 123 ? N VAL C 123 O TYR A 154 ? O TYR C 154 
AA1 5 6 N VAL A 153 ? N VAL C 153 O PHE A 207 ? O PHE C 207 
AA1 6 7 O VAL A 202 ? O VAL C 202 N LEU A 182 ? N LEU C 182 
AA2 1 2 N LYS A 132 ? N LYS C 132 O LYS A 135 ? O LYS C 135 
AA3 1 2 N ARG B 31  ? N ARG D 31  O GLU B 92  ? O GLU D 92  
AA3 2 3 N GLY B 96  ? N GLY D 96  O ILE B 109 ? O ILE D 109 
AA3 3 4 N SER B 110 ? N SER D 110 O ILE B 113 ? O ILE D 113 
# 
_pdbx_entry_details.entry_id                   9OHL 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O C HOH 423 ? ? O C HOH 599 ? ? 1.08 
2 1 O D HOH 322 ? ? O D HOH 367 ? ? 1.14 
3 1 O C HOH 401 ? ? O C HOH 566 ? ? 1.45 
4 1 O D HOH 387 ? ? O D HOH 414 ? ? 1.73 
5 1 O C HOH 410 ? ? O C HOH 613 ? ? 1.90 
6 1 N D GLY 73  ? ? O D HOH 301 ? ? 1.92 
7 1 O C HOH 416 ? ? O C HOH 643 ? ? 2.00 
8 1 O D HOH 424 ? ? O D HOH 457 ? ? 2.01 
9 1 O D HOH 445 ? ? O D HOH 459 ? ? 2.15 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O C HOH 451 ? ? 1_555 O C HOH 624 ? ? 4_455 1.90 
2 1 O C HOH 569 ? ? 1_555 O D HOH 356 ? ? 3_555 2.11 
3 1 O C HOH 443 ? ? 1_555 O D HOH 388 ? ? 3_555 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ILE C 50  ? ? -123.99 -50.60 
2 1 ASN C 101 ? ? -92.18  41.07  
3 1 ASN C 134 ? ? 75.41   -5.52  
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    D 
_pdbx_validate_planes.auth_seq_id     82 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.094 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 C MET 1   ? A MET 1   
2 1 Y 1 C LYS 2   ? A LYS 2   
3 1 Y 1 D GLU 120 ? B GLU 120 
4 1 Y 1 D GLU 121 ? B GLU 121 
5 1 Y 1 D GLU 122 ? B GLU 122 
6 1 Y 1 D THR 123 ? B THR 123 
7 1 Y 1 D GLU 124 ? B GLU 124 
8 1 Y 1 D SER 125 ? B SER 125 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1CBE C1     C  N N 1   
A1CBE C2     C  N N 2   
A1CBE O2     O  N N 3   
A1CBE C4     C  Y N 4   
A1CBE C5     C  Y N 5   
A1CBE C6     C  Y N 6   
A1CBE C7     C  Y N 7   
A1CBE C8     C  Y N 8   
A1CBE C9     C  N R 9   
A1CBE C12    C  Y N 10  
A1CBE C13    C  Y N 11  
A1CBE C14    C  Y N 12  
A1CBE C15    C  Y N 13  
A1CBE C16    C  Y N 14  
A1CBE C17    C  Y N 15  
A1CBE C19    C  N R 16  
A1CBE C20    C  N N 17  
A1CBE CL1    CL N N 18  
A1CBE O1     O  N N 19  
A1CBE N1     N  N N 20  
A1CBE C3     C  Y N 21  
A1CBE C10    C  N N 22  
A1CBE C11    C  N S 23  
A1CBE C18    C  N S 24  
A1CBE N2     N  N N 25  
A1CBE C21    C  N N 26  
A1CBE C22    C  N N 27  
A1CBE C23    C  N N 28  
A1CBE O3     O  N N 29  
A1CBE C24    C  N N 30  
A1CBE H1     H  N N 31  
A1CBE H2     H  N N 32  
A1CBE H3     H  N N 33  
A1CBE H4     H  N N 34  
A1CBE H5     H  N N 35  
A1CBE H6     H  N N 36  
A1CBE H7     H  N N 37  
A1CBE H8     H  N N 38  
A1CBE H9     H  N N 39  
A1CBE H10    H  N N 40  
A1CBE H11    H  N N 41  
A1CBE H12    H  N N 42  
A1CBE H13    H  N N 43  
A1CBE H14    H  N N 44  
A1CBE H15    H  N N 45  
A1CBE H16    H  N N 46  
A1CBE H17    H  N N 47  
A1CBE H18    H  N N 48  
A1CBE H19    H  N N 49  
A1CBE H20    H  N N 50  
A1CBE H21    H  N N 51  
A1CBE H22    H  N N 52  
A1CBE H23    H  N N 53  
A1CBE H24    H  N N 54  
A1CBE H25    H  N N 55  
A1CBE H26    H  N N 56  
A1CBE H27    H  N N 57  
ALA   N      N  N N 58  
ALA   CA     C  N S 59  
ALA   C      C  N N 60  
ALA   O      O  N N 61  
ALA   CB     C  N N 62  
ALA   OXT    O  N N 63  
ALA   H      H  N N 64  
ALA   H2     H  N N 65  
ALA   HA     H  N N 66  
ALA   HB1    H  N N 67  
ALA   HB2    H  N N 68  
ALA   HB3    H  N N 69  
ALA   HXT    H  N N 70  
ARG   N      N  N N 71  
ARG   CA     C  N S 72  
ARG   C      C  N N 73  
ARG   O      O  N N 74  
ARG   CB     C  N N 75  
ARG   CG     C  N N 76  
ARG   CD     C  N N 77  
ARG   NE     N  N N 78  
ARG   CZ     C  N N 79  
ARG   NH1    N  N N 80  
ARG   NH2    N  N N 81  
ARG   OXT    O  N N 82  
ARG   H      H  N N 83  
ARG   H2     H  N N 84  
ARG   HA     H  N N 85  
ARG   HB2    H  N N 86  
ARG   HB3    H  N N 87  
ARG   HG2    H  N N 88  
ARG   HG3    H  N N 89  
ARG   HD2    H  N N 90  
ARG   HD3    H  N N 91  
ARG   HE     H  N N 92  
ARG   HH11   H  N N 93  
ARG   HH12   H  N N 94  
ARG   HH21   H  N N 95  
ARG   HH22   H  N N 96  
ARG   HXT    H  N N 97  
ASN   N      N  N N 98  
ASN   CA     C  N S 99  
ASN   C      C  N N 100 
ASN   O      O  N N 101 
ASN   CB     C  N N 102 
ASN   CG     C  N N 103 
ASN   OD1    O  N N 104 
ASN   ND2    N  N N 105 
ASN   OXT    O  N N 106 
ASN   H      H  N N 107 
ASN   H2     H  N N 108 
ASN   HA     H  N N 109 
ASN   HB2    H  N N 110 
ASN   HB3    H  N N 111 
ASN   HD21   H  N N 112 
ASN   HD22   H  N N 113 
ASN   HXT    H  N N 114 
ASP   N      N  N N 115 
ASP   CA     C  N S 116 
ASP   C      C  N N 117 
ASP   O      O  N N 118 
ASP   CB     C  N N 119 
ASP   CG     C  N N 120 
ASP   OD1    O  N N 121 
ASP   OD2    O  N N 122 
ASP   OXT    O  N N 123 
ASP   H      H  N N 124 
ASP   H2     H  N N 125 
ASP   HA     H  N N 126 
ASP   HB2    H  N N 127 
ASP   HB3    H  N N 128 
ASP   HD2    H  N N 129 
ASP   HXT    H  N N 130 
CYS   N      N  N N 131 
CYS   CA     C  N R 132 
CYS   C      C  N N 133 
CYS   O      O  N N 134 
CYS   CB     C  N N 135 
CYS   SG     S  N N 136 
CYS   OXT    O  N N 137 
CYS   H      H  N N 138 
CYS   H2     H  N N 139 
CYS   HA     H  N N 140 
CYS   HB2    H  N N 141 
CYS   HB3    H  N N 142 
CYS   HG     H  N N 143 
CYS   HXT    H  N N 144 
GLN   N      N  N N 145 
GLN   CA     C  N S 146 
GLN   C      C  N N 147 
GLN   O      O  N N 148 
GLN   CB     C  N N 149 
GLN   CG     C  N N 150 
GLN   CD     C  N N 151 
GLN   OE1    O  N N 152 
GLN   NE2    N  N N 153 
GLN   OXT    O  N N 154 
GLN   H      H  N N 155 
GLN   H2     H  N N 156 
GLN   HA     H  N N 157 
GLN   HB2    H  N N 158 
GLN   HB3    H  N N 159 
GLN   HG2    H  N N 160 
GLN   HG3    H  N N 161 
GLN   HE21   H  N N 162 
GLN   HE22   H  N N 163 
GLN   HXT    H  N N 164 
GLU   N      N  N N 165 
GLU   CA     C  N S 166 
GLU   C      C  N N 167 
GLU   O      O  N N 168 
GLU   CB     C  N N 169 
GLU   CG     C  N N 170 
GLU   CD     C  N N 171 
GLU   OE1    O  N N 172 
GLU   OE2    O  N N 173 
GLU   OXT    O  N N 174 
GLU   H      H  N N 175 
GLU   H2     H  N N 176 
GLU   HA     H  N N 177 
GLU   HB2    H  N N 178 
GLU   HB3    H  N N 179 
GLU   HG2    H  N N 180 
GLU   HG3    H  N N 181 
GLU   HE2    H  N N 182 
GLU   HXT    H  N N 183 
GLY   N      N  N N 184 
GLY   CA     C  N N 185 
GLY   C      C  N N 186 
GLY   O      O  N N 187 
GLY   OXT    O  N N 188 
GLY   H      H  N N 189 
GLY   H2     H  N N 190 
GLY   HA2    H  N N 191 
GLY   HA3    H  N N 192 
GLY   HXT    H  N N 193 
GOL   C1     C  N N 194 
GOL   O1     O  N N 195 
GOL   C2     C  N N 196 
GOL   O2     O  N N 197 
GOL   C3     C  N N 198 
GOL   O3     O  N N 199 
GOL   H11    H  N N 200 
GOL   H12    H  N N 201 
GOL   HO1    H  N N 202 
GOL   H2     H  N N 203 
GOL   HO2    H  N N 204 
GOL   H31    H  N N 205 
GOL   H32    H  N N 206 
GOL   HO3    H  N N 207 
HIS   N      N  N N 208 
HIS   CA     C  N S 209 
HIS   C      C  N N 210 
HIS   O      O  N N 211 
HIS   CB     C  N N 212 
HIS   CG     C  Y N 213 
HIS   ND1    N  Y N 214 
HIS   CD2    C  Y N 215 
HIS   CE1    C  Y N 216 
HIS   NE2    N  Y N 217 
HIS   OXT    O  N N 218 
HIS   H      H  N N 219 
HIS   H2     H  N N 220 
HIS   HA     H  N N 221 
HIS   HB2    H  N N 222 
HIS   HB3    H  N N 223 
HIS   HD1    H  N N 224 
HIS   HD2    H  N N 225 
HIS   HE1    H  N N 226 
HIS   HE2    H  N N 227 
HIS   HXT    H  N N 228 
HOH   O      O  N N 229 
HOH   H1     H  N N 230 
HOH   H2     H  N N 231 
ILE   N      N  N N 232 
ILE   CA     C  N S 233 
ILE   C      C  N N 234 
ILE   O      O  N N 235 
ILE   CB     C  N S 236 
ILE   CG1    C  N N 237 
ILE   CG2    C  N N 238 
ILE   CD1    C  N N 239 
ILE   OXT    O  N N 240 
ILE   H      H  N N 241 
ILE   H2     H  N N 242 
ILE   HA     H  N N 243 
ILE   HB     H  N N 244 
ILE   HG12   H  N N 245 
ILE   HG13   H  N N 246 
ILE   HG21   H  N N 247 
ILE   HG22   H  N N 248 
ILE   HG23   H  N N 249 
ILE   HD11   H  N N 250 
ILE   HD12   H  N N 251 
ILE   HD13   H  N N 252 
ILE   HXT    H  N N 253 
LEU   N      N  N N 254 
LEU   CA     C  N S 255 
LEU   C      C  N N 256 
LEU   O      O  N N 257 
LEU   CB     C  N N 258 
LEU   CG     C  N N 259 
LEU   CD1    C  N N 260 
LEU   CD2    C  N N 261 
LEU   OXT    O  N N 262 
LEU   H      H  N N 263 
LEU   H2     H  N N 264 
LEU   HA     H  N N 265 
LEU   HB2    H  N N 266 
LEU   HB3    H  N N 267 
LEU   HG     H  N N 268 
LEU   HD11   H  N N 269 
LEU   HD12   H  N N 270 
LEU   HD13   H  N N 271 
LEU   HD21   H  N N 272 
LEU   HD22   H  N N 273 
LEU   HD23   H  N N 274 
LEU   HXT    H  N N 275 
LYS   N      N  N N 276 
LYS   CA     C  N S 277 
LYS   C      C  N N 278 
LYS   O      O  N N 279 
LYS   CB     C  N N 280 
LYS   CG     C  N N 281 
LYS   CD     C  N N 282 
LYS   CE     C  N N 283 
LYS   NZ     N  N N 284 
LYS   OXT    O  N N 285 
LYS   H      H  N N 286 
LYS   H2     H  N N 287 
LYS   HA     H  N N 288 
LYS   HB2    H  N N 289 
LYS   HB3    H  N N 290 
LYS   HG2    H  N N 291 
LYS   HG3    H  N N 292 
LYS   HD2    H  N N 293 
LYS   HD3    H  N N 294 
LYS   HE2    H  N N 295 
LYS   HE3    H  N N 296 
LYS   HZ1    H  N N 297 
LYS   HZ2    H  N N 298 
LYS   HZ3    H  N N 299 
LYS   HXT    H  N N 300 
MET   N      N  N N 301 
MET   CA     C  N S 302 
MET   C      C  N N 303 
MET   O      O  N N 304 
MET   CB     C  N N 305 
MET   CG     C  N N 306 
MET   SD     S  N N 307 
MET   CE     C  N N 308 
MET   OXT    O  N N 309 
MET   H      H  N N 310 
MET   H2     H  N N 311 
MET   HA     H  N N 312 
MET   HB2    H  N N 313 
MET   HB3    H  N N 314 
MET   HG2    H  N N 315 
MET   HG3    H  N N 316 
MET   HE1    H  N N 317 
MET   HE2    H  N N 318 
MET   HE3    H  N N 319 
MET   HXT    H  N N 320 
PHE   N      N  N N 321 
PHE   CA     C  N S 322 
PHE   C      C  N N 323 
PHE   O      O  N N 324 
PHE   CB     C  N N 325 
PHE   CG     C  Y N 326 
PHE   CD1    C  Y N 327 
PHE   CD2    C  Y N 328 
PHE   CE1    C  Y N 329 
PHE   CE2    C  Y N 330 
PHE   CZ     C  Y N 331 
PHE   OXT    O  N N 332 
PHE   H      H  N N 333 
PHE   H2     H  N N 334 
PHE   HA     H  N N 335 
PHE   HB2    H  N N 336 
PHE   HB3    H  N N 337 
PHE   HD1    H  N N 338 
PHE   HD2    H  N N 339 
PHE   HE1    H  N N 340 
PHE   HE2    H  N N 341 
PHE   HZ     H  N N 342 
PHE   HXT    H  N N 343 
PRO   N      N  N N 344 
PRO   CA     C  N S 345 
PRO   C      C  N N 346 
PRO   O      O  N N 347 
PRO   CB     C  N N 348 
PRO   CG     C  N N 349 
PRO   CD     C  N N 350 
PRO   OXT    O  N N 351 
PRO   H      H  N N 352 
PRO   HA     H  N N 353 
PRO   HB2    H  N N 354 
PRO   HB3    H  N N 355 
PRO   HG2    H  N N 356 
PRO   HG3    H  N N 357 
PRO   HD2    H  N N 358 
PRO   HD3    H  N N 359 
PRO   HXT    H  N N 360 
SAM   N      N  N N 361 
SAM   CA     C  N S 362 
SAM   C      C  N N 363 
SAM   O      O  N N 364 
SAM   OXT    O  N N 365 
SAM   CB     C  N N 366 
SAM   CG     C  N N 367 
SAM   SD     S  N S 368 
SAM   CE     C  N N 369 
SAM   "C5'"  C  N N 370 
SAM   "C4'"  C  N S 371 
SAM   "O4'"  O  N N 372 
SAM   "C3'"  C  N S 373 
SAM   "O3'"  O  N N 374 
SAM   "C2'"  C  N R 375 
SAM   "O2'"  O  N N 376 
SAM   "C1'"  C  N R 377 
SAM   N9     N  Y N 378 
SAM   C8     C  Y N 379 
SAM   N7     N  Y N 380 
SAM   C5     C  Y N 381 
SAM   C6     C  Y N 382 
SAM   N6     N  N N 383 
SAM   N1     N  Y N 384 
SAM   C2     C  Y N 385 
SAM   N3     N  Y N 386 
SAM   C4     C  Y N 387 
SAM   HN1    H  N N 388 
SAM   HN2    H  N N 389 
SAM   HA     H  N N 390 
SAM   HB1    H  N N 391 
SAM   HB2    H  N N 392 
SAM   HG1    H  N N 393 
SAM   HG2    H  N N 394 
SAM   HE1    H  N N 395 
SAM   HE2    H  N N 396 
SAM   HE3    H  N N 397 
SAM   "H5'1" H  N N 398 
SAM   "H5'2" H  N N 399 
SAM   "H4'"  H  N N 400 
SAM   "H3'"  H  N N 401 
SAM   "HO3'" H  N N 402 
SAM   "H2'"  H  N N 403 
SAM   "HO2'" H  N N 404 
SAM   "H1'"  H  N N 405 
SAM   H8     H  N N 406 
SAM   HN61   H  N N 407 
SAM   HN62   H  N N 408 
SAM   H2     H  N N 409 
SER   N      N  N N 410 
SER   CA     C  N S 411 
SER   C      C  N N 412 
SER   O      O  N N 413 
SER   CB     C  N N 414 
SER   OG     O  N N 415 
SER   OXT    O  N N 416 
SER   H      H  N N 417 
SER   H2     H  N N 418 
SER   HA     H  N N 419 
SER   HB2    H  N N 420 
SER   HB3    H  N N 421 
SER   HG     H  N N 422 
SER   HXT    H  N N 423 
THR   N      N  N N 424 
THR   CA     C  N S 425 
THR   C      C  N N 426 
THR   O      O  N N 427 
THR   CB     C  N R 428 
THR   OG1    O  N N 429 
THR   CG2    C  N N 430 
THR   OXT    O  N N 431 
THR   H      H  N N 432 
THR   H2     H  N N 433 
THR   HA     H  N N 434 
THR   HB     H  N N 435 
THR   HG1    H  N N 436 
THR   HG21   H  N N 437 
THR   HG22   H  N N 438 
THR   HG23   H  N N 439 
THR   HXT    H  N N 440 
TRP   N      N  N N 441 
TRP   CA     C  N S 442 
TRP   C      C  N N 443 
TRP   O      O  N N 444 
TRP   CB     C  N N 445 
TRP   CG     C  Y N 446 
TRP   CD1    C  Y N 447 
TRP   CD2    C  Y N 448 
TRP   NE1    N  Y N 449 
TRP   CE2    C  Y N 450 
TRP   CE3    C  Y N 451 
TRP   CZ2    C  Y N 452 
TRP   CZ3    C  Y N 453 
TRP   CH2    C  Y N 454 
TRP   OXT    O  N N 455 
TRP   H      H  N N 456 
TRP   H2     H  N N 457 
TRP   HA     H  N N 458 
TRP   HB2    H  N N 459 
TRP   HB3    H  N N 460 
TRP   HD1    H  N N 461 
TRP   HE1    H  N N 462 
TRP   HE3    H  N N 463 
TRP   HZ2    H  N N 464 
TRP   HZ3    H  N N 465 
TRP   HH2    H  N N 466 
TRP   HXT    H  N N 467 
TYR   N      N  N N 468 
TYR   CA     C  N S 469 
TYR   C      C  N N 470 
TYR   O      O  N N 471 
TYR   CB     C  N N 472 
TYR   CG     C  Y N 473 
TYR   CD1    C  Y N 474 
TYR   CD2    C  Y N 475 
TYR   CE1    C  Y N 476 
TYR   CE2    C  Y N 477 
TYR   CZ     C  Y N 478 
TYR   OH     O  N N 479 
TYR   OXT    O  N N 480 
TYR   H      H  N N 481 
TYR   H2     H  N N 482 
TYR   HA     H  N N 483 
TYR   HB2    H  N N 484 
TYR   HB3    H  N N 485 
TYR   HD1    H  N N 486 
TYR   HD2    H  N N 487 
TYR   HE1    H  N N 488 
TYR   HE2    H  N N 489 
TYR   HH     H  N N 490 
TYR   HXT    H  N N 491 
VAL   N      N  N N 492 
VAL   CA     C  N S 493 
VAL   C      C  N N 494 
VAL   O      O  N N 495 
VAL   CB     C  N N 496 
VAL   CG1    C  N N 497 
VAL   CG2    C  N N 498 
VAL   OXT    O  N N 499 
VAL   H      H  N N 500 
VAL   H2     H  N N 501 
VAL   HA     H  N N 502 
VAL   HB     H  N N 503 
VAL   HG11   H  N N 504 
VAL   HG12   H  N N 505 
VAL   HG13   H  N N 506 
VAL   HG21   H  N N 507 
VAL   HG22   H  N N 508 
VAL   HG23   H  N N 509 
VAL   HXT    H  N N 510 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1CBE C2    C1     sing N N 1   
A1CBE O1    C1     doub N N 2   
A1CBE C1    N1     sing N N 3   
A1CBE N1    C3     sing N N 4   
A1CBE C3    C4     doub Y N 5   
A1CBE C3    C6     sing Y N 6   
A1CBE C4    C5     sing Y N 7   
A1CBE C6    C7     doub Y N 8   
A1CBE C5    C8     doub Y N 9   
A1CBE C7    C8     sing Y N 10  
A1CBE C8    O2     sing N N 11  
A1CBE C24   C18    sing N N 12  
A1CBE C24   N2     sing N N 13  
A1CBE C18   C19    sing N N 14  
A1CBE C18   C9     sing N N 15  
A1CBE N2    C20    sing N N 16  
A1CBE N2    C21    sing N N 17  
A1CBE C20   C19    sing N N 18  
A1CBE O3    C21    doub N N 19  
A1CBE C21   C22    sing N N 20  
A1CBE C19   C11    sing N N 21  
A1CBE O2    C9     sing N N 22  
A1CBE C22   C23    sing N N 23  
A1CBE C9    C10    sing N N 24  
A1CBE C11   C10    sing N N 25  
A1CBE C11   C12    sing N N 26  
A1CBE C13   C12    doub Y N 27  
A1CBE C13   C14    sing Y N 28  
A1CBE C12   C17    sing Y N 29  
A1CBE CL1   C14    sing N N 30  
A1CBE C14   C15    doub Y N 31  
A1CBE C17   C16    doub Y N 32  
A1CBE C15   C16    sing Y N 33  
A1CBE C2    H1     sing N N 34  
A1CBE C2    H2     sing N N 35  
A1CBE C2    H3     sing N N 36  
A1CBE C4    H4     sing N N 37  
A1CBE C5    H5     sing N N 38  
A1CBE C6    H6     sing N N 39  
A1CBE C7    H7     sing N N 40  
A1CBE C9    H8     sing N N 41  
A1CBE C13   H9     sing N N 42  
A1CBE C15   H10    sing N N 43  
A1CBE C16   H11    sing N N 44  
A1CBE C17   H12    sing N N 45  
A1CBE C19   H13    sing N N 46  
A1CBE C20   H14    sing N N 47  
A1CBE C20   H15    sing N N 48  
A1CBE N1    H16    sing N N 49  
A1CBE C10   H17    sing N N 50  
A1CBE C10   H18    sing N N 51  
A1CBE C11   H19    sing N N 52  
A1CBE C18   H20    sing N N 53  
A1CBE C22   H21    sing N N 54  
A1CBE C22   H22    sing N N 55  
A1CBE C23   H23    sing N N 56  
A1CBE C23   H24    sing N N 57  
A1CBE C23   H25    sing N N 58  
A1CBE C24   H26    sing N N 59  
A1CBE C24   H27    sing N N 60  
ALA   N     CA     sing N N 61  
ALA   N     H      sing N N 62  
ALA   N     H2     sing N N 63  
ALA   CA    C      sing N N 64  
ALA   CA    CB     sing N N 65  
ALA   CA    HA     sing N N 66  
ALA   C     O      doub N N 67  
ALA   C     OXT    sing N N 68  
ALA   CB    HB1    sing N N 69  
ALA   CB    HB2    sing N N 70  
ALA   CB    HB3    sing N N 71  
ALA   OXT   HXT    sing N N 72  
ARG   N     CA     sing N N 73  
ARG   N     H      sing N N 74  
ARG   N     H2     sing N N 75  
ARG   CA    C      sing N N 76  
ARG   CA    CB     sing N N 77  
ARG   CA    HA     sing N N 78  
ARG   C     O      doub N N 79  
ARG   C     OXT    sing N N 80  
ARG   CB    CG     sing N N 81  
ARG   CB    HB2    sing N N 82  
ARG   CB    HB3    sing N N 83  
ARG   CG    CD     sing N N 84  
ARG   CG    HG2    sing N N 85  
ARG   CG    HG3    sing N N 86  
ARG   CD    NE     sing N N 87  
ARG   CD    HD2    sing N N 88  
ARG   CD    HD3    sing N N 89  
ARG   NE    CZ     sing N N 90  
ARG   NE    HE     sing N N 91  
ARG   CZ    NH1    sing N N 92  
ARG   CZ    NH2    doub N N 93  
ARG   NH1   HH11   sing N N 94  
ARG   NH1   HH12   sing N N 95  
ARG   NH2   HH21   sing N N 96  
ARG   NH2   HH22   sing N N 97  
ARG   OXT   HXT    sing N N 98  
ASN   N     CA     sing N N 99  
ASN   N     H      sing N N 100 
ASN   N     H2     sing N N 101 
ASN   CA    C      sing N N 102 
ASN   CA    CB     sing N N 103 
ASN   CA    HA     sing N N 104 
ASN   C     O      doub N N 105 
ASN   C     OXT    sing N N 106 
ASN   CB    CG     sing N N 107 
ASN   CB    HB2    sing N N 108 
ASN   CB    HB3    sing N N 109 
ASN   CG    OD1    doub N N 110 
ASN   CG    ND2    sing N N 111 
ASN   ND2   HD21   sing N N 112 
ASN   ND2   HD22   sing N N 113 
ASN   OXT   HXT    sing N N 114 
ASP   N     CA     sing N N 115 
ASP   N     H      sing N N 116 
ASP   N     H2     sing N N 117 
ASP   CA    C      sing N N 118 
ASP   CA    CB     sing N N 119 
ASP   CA    HA     sing N N 120 
ASP   C     O      doub N N 121 
ASP   C     OXT    sing N N 122 
ASP   CB    CG     sing N N 123 
ASP   CB    HB2    sing N N 124 
ASP   CB    HB3    sing N N 125 
ASP   CG    OD1    doub N N 126 
ASP   CG    OD2    sing N N 127 
ASP   OD2   HD2    sing N N 128 
ASP   OXT   HXT    sing N N 129 
CYS   N     CA     sing N N 130 
CYS   N     H      sing N N 131 
CYS   N     H2     sing N N 132 
CYS   CA    C      sing N N 133 
CYS   CA    CB     sing N N 134 
CYS   CA    HA     sing N N 135 
CYS   C     O      doub N N 136 
CYS   C     OXT    sing N N 137 
CYS   CB    SG     sing N N 138 
CYS   CB    HB2    sing N N 139 
CYS   CB    HB3    sing N N 140 
CYS   SG    HG     sing N N 141 
CYS   OXT   HXT    sing N N 142 
GLN   N     CA     sing N N 143 
GLN   N     H      sing N N 144 
GLN   N     H2     sing N N 145 
GLN   CA    C      sing N N 146 
GLN   CA    CB     sing N N 147 
GLN   CA    HA     sing N N 148 
GLN   C     O      doub N N 149 
GLN   C     OXT    sing N N 150 
GLN   CB    CG     sing N N 151 
GLN   CB    HB2    sing N N 152 
GLN   CB    HB3    sing N N 153 
GLN   CG    CD     sing N N 154 
GLN   CG    HG2    sing N N 155 
GLN   CG    HG3    sing N N 156 
GLN   CD    OE1    doub N N 157 
GLN   CD    NE2    sing N N 158 
GLN   NE2   HE21   sing N N 159 
GLN   NE2   HE22   sing N N 160 
GLN   OXT   HXT    sing N N 161 
GLU   N     CA     sing N N 162 
GLU   N     H      sing N N 163 
GLU   N     H2     sing N N 164 
GLU   CA    C      sing N N 165 
GLU   CA    CB     sing N N 166 
GLU   CA    HA     sing N N 167 
GLU   C     O      doub N N 168 
GLU   C     OXT    sing N N 169 
GLU   CB    CG     sing N N 170 
GLU   CB    HB2    sing N N 171 
GLU   CB    HB3    sing N N 172 
GLU   CG    CD     sing N N 173 
GLU   CG    HG2    sing N N 174 
GLU   CG    HG3    sing N N 175 
GLU   CD    OE1    doub N N 176 
GLU   CD    OE2    sing N N 177 
GLU   OE2   HE2    sing N N 178 
GLU   OXT   HXT    sing N N 179 
GLY   N     CA     sing N N 180 
GLY   N     H      sing N N 181 
GLY   N     H2     sing N N 182 
GLY   CA    C      sing N N 183 
GLY   CA    HA2    sing N N 184 
GLY   CA    HA3    sing N N 185 
GLY   C     O      doub N N 186 
GLY   C     OXT    sing N N 187 
GLY   OXT   HXT    sing N N 188 
GOL   C1    O1     sing N N 189 
GOL   C1    C2     sing N N 190 
GOL   C1    H11    sing N N 191 
GOL   C1    H12    sing N N 192 
GOL   O1    HO1    sing N N 193 
GOL   C2    O2     sing N N 194 
GOL   C2    C3     sing N N 195 
GOL   C2    H2     sing N N 196 
GOL   O2    HO2    sing N N 197 
GOL   C3    O3     sing N N 198 
GOL   C3    H31    sing N N 199 
GOL   C3    H32    sing N N 200 
GOL   O3    HO3    sing N N 201 
HIS   N     CA     sing N N 202 
HIS   N     H      sing N N 203 
HIS   N     H2     sing N N 204 
HIS   CA    C      sing N N 205 
HIS   CA    CB     sing N N 206 
HIS   CA    HA     sing N N 207 
HIS   C     O      doub N N 208 
HIS   C     OXT    sing N N 209 
HIS   CB    CG     sing N N 210 
HIS   CB    HB2    sing N N 211 
HIS   CB    HB3    sing N N 212 
HIS   CG    ND1    sing Y N 213 
HIS   CG    CD2    doub Y N 214 
HIS   ND1   CE1    doub Y N 215 
HIS   ND1   HD1    sing N N 216 
HIS   CD2   NE2    sing Y N 217 
HIS   CD2   HD2    sing N N 218 
HIS   CE1   NE2    sing Y N 219 
HIS   CE1   HE1    sing N N 220 
HIS   NE2   HE2    sing N N 221 
HIS   OXT   HXT    sing N N 222 
HOH   O     H1     sing N N 223 
HOH   O     H2     sing N N 224 
ILE   N     CA     sing N N 225 
ILE   N     H      sing N N 226 
ILE   N     H2     sing N N 227 
ILE   CA    C      sing N N 228 
ILE   CA    CB     sing N N 229 
ILE   CA    HA     sing N N 230 
ILE   C     O      doub N N 231 
ILE   C     OXT    sing N N 232 
ILE   CB    CG1    sing N N 233 
ILE   CB    CG2    sing N N 234 
ILE   CB    HB     sing N N 235 
ILE   CG1   CD1    sing N N 236 
ILE   CG1   HG12   sing N N 237 
ILE   CG1   HG13   sing N N 238 
ILE   CG2   HG21   sing N N 239 
ILE   CG2   HG22   sing N N 240 
ILE   CG2   HG23   sing N N 241 
ILE   CD1   HD11   sing N N 242 
ILE   CD1   HD12   sing N N 243 
ILE   CD1   HD13   sing N N 244 
ILE   OXT   HXT    sing N N 245 
LEU   N     CA     sing N N 246 
LEU   N     H      sing N N 247 
LEU   N     H2     sing N N 248 
LEU   CA    C      sing N N 249 
LEU   CA    CB     sing N N 250 
LEU   CA    HA     sing N N 251 
LEU   C     O      doub N N 252 
LEU   C     OXT    sing N N 253 
LEU   CB    CG     sing N N 254 
LEU   CB    HB2    sing N N 255 
LEU   CB    HB3    sing N N 256 
LEU   CG    CD1    sing N N 257 
LEU   CG    CD2    sing N N 258 
LEU   CG    HG     sing N N 259 
LEU   CD1   HD11   sing N N 260 
LEU   CD1   HD12   sing N N 261 
LEU   CD1   HD13   sing N N 262 
LEU   CD2   HD21   sing N N 263 
LEU   CD2   HD22   sing N N 264 
LEU   CD2   HD23   sing N N 265 
LEU   OXT   HXT    sing N N 266 
LYS   N     CA     sing N N 267 
LYS   N     H      sing N N 268 
LYS   N     H2     sing N N 269 
LYS   CA    C      sing N N 270 
LYS   CA    CB     sing N N 271 
LYS   CA    HA     sing N N 272 
LYS   C     O      doub N N 273 
LYS   C     OXT    sing N N 274 
LYS   CB    CG     sing N N 275 
LYS   CB    HB2    sing N N 276 
LYS   CB    HB3    sing N N 277 
LYS   CG    CD     sing N N 278 
LYS   CG    HG2    sing N N 279 
LYS   CG    HG3    sing N N 280 
LYS   CD    CE     sing N N 281 
LYS   CD    HD2    sing N N 282 
LYS   CD    HD3    sing N N 283 
LYS   CE    NZ     sing N N 284 
LYS   CE    HE2    sing N N 285 
LYS   CE    HE3    sing N N 286 
LYS   NZ    HZ1    sing N N 287 
LYS   NZ    HZ2    sing N N 288 
LYS   NZ    HZ3    sing N N 289 
LYS   OXT   HXT    sing N N 290 
MET   N     CA     sing N N 291 
MET   N     H      sing N N 292 
MET   N     H2     sing N N 293 
MET   CA    C      sing N N 294 
MET   CA    CB     sing N N 295 
MET   CA    HA     sing N N 296 
MET   C     O      doub N N 297 
MET   C     OXT    sing N N 298 
MET   CB    CG     sing N N 299 
MET   CB    HB2    sing N N 300 
MET   CB    HB3    sing N N 301 
MET   CG    SD     sing N N 302 
MET   CG    HG2    sing N N 303 
MET   CG    HG3    sing N N 304 
MET   SD    CE     sing N N 305 
MET   CE    HE1    sing N N 306 
MET   CE    HE2    sing N N 307 
MET   CE    HE3    sing N N 308 
MET   OXT   HXT    sing N N 309 
PHE   N     CA     sing N N 310 
PHE   N     H      sing N N 311 
PHE   N     H2     sing N N 312 
PHE   CA    C      sing N N 313 
PHE   CA    CB     sing N N 314 
PHE   CA    HA     sing N N 315 
PHE   C     O      doub N N 316 
PHE   C     OXT    sing N N 317 
PHE   CB    CG     sing N N 318 
PHE   CB    HB2    sing N N 319 
PHE   CB    HB3    sing N N 320 
PHE   CG    CD1    doub Y N 321 
PHE   CG    CD2    sing Y N 322 
PHE   CD1   CE1    sing Y N 323 
PHE   CD1   HD1    sing N N 324 
PHE   CD2   CE2    doub Y N 325 
PHE   CD2   HD2    sing N N 326 
PHE   CE1   CZ     doub Y N 327 
PHE   CE1   HE1    sing N N 328 
PHE   CE2   CZ     sing Y N 329 
PHE   CE2   HE2    sing N N 330 
PHE   CZ    HZ     sing N N 331 
PHE   OXT   HXT    sing N N 332 
PRO   N     CA     sing N N 333 
PRO   N     CD     sing N N 334 
PRO   N     H      sing N N 335 
PRO   CA    C      sing N N 336 
PRO   CA    CB     sing N N 337 
PRO   CA    HA     sing N N 338 
PRO   C     O      doub N N 339 
PRO   C     OXT    sing N N 340 
PRO   CB    CG     sing N N 341 
PRO   CB    HB2    sing N N 342 
PRO   CB    HB3    sing N N 343 
PRO   CG    CD     sing N N 344 
PRO   CG    HG2    sing N N 345 
PRO   CG    HG3    sing N N 346 
PRO   CD    HD2    sing N N 347 
PRO   CD    HD3    sing N N 348 
PRO   OXT   HXT    sing N N 349 
SAM   N     CA     sing N N 350 
SAM   N     HN1    sing N N 351 
SAM   N     HN2    sing N N 352 
SAM   CA    C      sing N N 353 
SAM   CA    CB     sing N N 354 
SAM   CA    HA     sing N N 355 
SAM   C     O      doub N N 356 
SAM   C     OXT    sing N N 357 
SAM   CB    CG     sing N N 358 
SAM   CB    HB1    sing N N 359 
SAM   CB    HB2    sing N N 360 
SAM   CG    SD     sing N N 361 
SAM   CG    HG1    sing N N 362 
SAM   CG    HG2    sing N N 363 
SAM   SD    CE     sing N N 364 
SAM   SD    "C5'"  sing N N 365 
SAM   CE    HE1    sing N N 366 
SAM   CE    HE2    sing N N 367 
SAM   CE    HE3    sing N N 368 
SAM   "C5'" "C4'"  sing N N 369 
SAM   "C5'" "H5'1" sing N N 370 
SAM   "C5'" "H5'2" sing N N 371 
SAM   "C4'" "O4'"  sing N N 372 
SAM   "C4'" "C3'"  sing N N 373 
SAM   "C4'" "H4'"  sing N N 374 
SAM   "O4'" "C1'"  sing N N 375 
SAM   "C3'" "O3'"  sing N N 376 
SAM   "C3'" "C2'"  sing N N 377 
SAM   "C3'" "H3'"  sing N N 378 
SAM   "O3'" "HO3'" sing N N 379 
SAM   "C2'" "O2'"  sing N N 380 
SAM   "C2'" "C1'"  sing N N 381 
SAM   "C2'" "H2'"  sing N N 382 
SAM   "O2'" "HO2'" sing N N 383 
SAM   "C1'" N9     sing N N 384 
SAM   "C1'" "H1'"  sing N N 385 
SAM   N9    C8     sing Y N 386 
SAM   N9    C4     sing Y N 387 
SAM   C8    N7     doub Y N 388 
SAM   C8    H8     sing N N 389 
SAM   N7    C5     sing Y N 390 
SAM   C5    C6     sing Y N 391 
SAM   C5    C4     doub Y N 392 
SAM   C6    N6     sing N N 393 
SAM   C6    N1     doub Y N 394 
SAM   N6    HN61   sing N N 395 
SAM   N6    HN62   sing N N 396 
SAM   N1    C2     sing Y N 397 
SAM   C2    N3     doub Y N 398 
SAM   C2    H2     sing N N 399 
SAM   N3    C4     sing Y N 400 
SER   N     CA     sing N N 401 
SER   N     H      sing N N 402 
SER   N     H2     sing N N 403 
SER   CA    C      sing N N 404 
SER   CA    CB     sing N N 405 
SER   CA    HA     sing N N 406 
SER   C     O      doub N N 407 
SER   C     OXT    sing N N 408 
SER   CB    OG     sing N N 409 
SER   CB    HB2    sing N N 410 
SER   CB    HB3    sing N N 411 
SER   OG    HG     sing N N 412 
SER   OXT   HXT    sing N N 413 
THR   N     CA     sing N N 414 
THR   N     H      sing N N 415 
THR   N     H2     sing N N 416 
THR   CA    C      sing N N 417 
THR   CA    CB     sing N N 418 
THR   CA    HA     sing N N 419 
THR   C     O      doub N N 420 
THR   C     OXT    sing N N 421 
THR   CB    OG1    sing N N 422 
THR   CB    CG2    sing N N 423 
THR   CB    HB     sing N N 424 
THR   OG1   HG1    sing N N 425 
THR   CG2   HG21   sing N N 426 
THR   CG2   HG22   sing N N 427 
THR   CG2   HG23   sing N N 428 
THR   OXT   HXT    sing N N 429 
TRP   N     CA     sing N N 430 
TRP   N     H      sing N N 431 
TRP   N     H2     sing N N 432 
TRP   CA    C      sing N N 433 
TRP   CA    CB     sing N N 434 
TRP   CA    HA     sing N N 435 
TRP   C     O      doub N N 436 
TRP   C     OXT    sing N N 437 
TRP   CB    CG     sing N N 438 
TRP   CB    HB2    sing N N 439 
TRP   CB    HB3    sing N N 440 
TRP   CG    CD1    doub Y N 441 
TRP   CG    CD2    sing Y N 442 
TRP   CD1   NE1    sing Y N 443 
TRP   CD1   HD1    sing N N 444 
TRP   CD2   CE2    doub Y N 445 
TRP   CD2   CE3    sing Y N 446 
TRP   NE1   CE2    sing Y N 447 
TRP   NE1   HE1    sing N N 448 
TRP   CE2   CZ2    sing Y N 449 
TRP   CE3   CZ3    doub Y N 450 
TRP   CE3   HE3    sing N N 451 
TRP   CZ2   CH2    doub Y N 452 
TRP   CZ2   HZ2    sing N N 453 
TRP   CZ3   CH2    sing Y N 454 
TRP   CZ3   HZ3    sing N N 455 
TRP   CH2   HH2    sing N N 456 
TRP   OXT   HXT    sing N N 457 
TYR   N     CA     sing N N 458 
TYR   N     H      sing N N 459 
TYR   N     H2     sing N N 460 
TYR   CA    C      sing N N 461 
TYR   CA    CB     sing N N 462 
TYR   CA    HA     sing N N 463 
TYR   C     O      doub N N 464 
TYR   C     OXT    sing N N 465 
TYR   CB    CG     sing N N 466 
TYR   CB    HB2    sing N N 467 
TYR   CB    HB3    sing N N 468 
TYR   CG    CD1    doub Y N 469 
TYR   CG    CD2    sing Y N 470 
TYR   CD1   CE1    sing Y N 471 
TYR   CD1   HD1    sing N N 472 
TYR   CD2   CE2    doub Y N 473 
TYR   CD2   HD2    sing N N 474 
TYR   CE1   CZ     doub Y N 475 
TYR   CE1   HE1    sing N N 476 
TYR   CE2   CZ     sing Y N 477 
TYR   CE2   HE2    sing N N 478 
TYR   CZ    OH     sing N N 479 
TYR   OH    HH     sing N N 480 
TYR   OXT   HXT    sing N N 481 
VAL   N     CA     sing N N 482 
VAL   N     H      sing N N 483 
VAL   N     H2     sing N N 484 
VAL   CA    C      sing N N 485 
VAL   CA    CB     sing N N 486 
VAL   CA    HA     sing N N 487 
VAL   C     O      doub N N 488 
VAL   C     OXT    sing N N 489 
VAL   CB    CG1    sing N N 490 
VAL   CB    CG2    sing N N 491 
VAL   CB    HB     sing N N 492 
VAL   CG1   HG11   sing N N 493 
VAL   CG1   HG12   sing N N 494 
VAL   CG1   HG13   sing N N 495 
VAL   CG2   HG21   sing N N 496 
VAL   CG2   HG22   sing N N 497 
VAL   CG2   HG23   sing N N 498 
VAL   OXT   HXT    sing N N 499 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' 'R35 CA231991' 1 
'Other private'                                                     ?               ?              2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6H2U 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9OHL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017642 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014156 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011827 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
CL 17 17 11.4601 0.0104  7.1962 1.1662  6.2554 18.5194 1.6455 47.7784 -9.3378  
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0555   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N     . LYS   A 1 3   ? 31.118  3.278   17.214  1.000 31.921 0 3   LYS   C N     1 ? 
ATOM   2    C  CA    . LYS   A 1 3   ? 30.471  4.566   17.600  1.000 30.326 0 3   LYS   C CA    1 ? 
ATOM   3    C  C     . LYS   A 1 3   ? 30.626  5.596   16.477  1.000 28.806 0 3   LYS   C C     1 ? 
ATOM   4    O  O     . LYS   A 1 3   ? 31.741  5.968   16.109  1.000 26.719 0 3   LYS   C O     1 ? 
ATOM   5    C  CB    . LYS   A 1 3   ? 31.066  5.095   18.905  1.000 36.624 0 3   LYS   C CB    1 ? 
ATOM   6    C  CG    . LYS   A 1 3   ? 30.683  6.523   19.274  1.000 40.865 0 3   LYS   C CG    1 ? 
ATOM   7    C  CD    . LYS   A 1 3   ? 29.186  6.795   19.249  1.000 44.703 0 3   LYS   C CD    1 ? 
ATOM   8    C  CE    . LYS   A 1 3   ? 28.819  8.259   19.104  1.000 48.021 0 3   LYS   C CE    1 ? 
ATOM   9    N  NZ    . LYS   A 1 3   ? 29.185  9.050   20.299  1.000 51.141 0 3   LYS   C NZ    1 ? 
ATOM   10   N  N     . VAL   A 1 4   ? 29.497  6.051   15.923  1.000 21.394 0 4   VAL   C N     1 ? 
ATOM   11   C  CA    . VAL   A 1 4   ? 29.500  7.056   14.867  1.000 21.835 0 4   VAL   C CA    1 ? 
ATOM   12   C  C     . VAL   A 1 4   ? 29.155  8.396   15.490  1.000 18.562 0 4   VAL   C C     1 ? 
ATOM   13   O  O     . VAL   A 1 4   ? 28.048  8.573   15.994  1.000 19.802 0 4   VAL   C O     1 ? 
ATOM   14   C  CB    . VAL   A 1 4   ? 28.476  6.691   13.775  1.000 19.283 0 4   VAL   C CB    1 ? 
ATOM   15   C  CG1   . VAL   A 1 4   ? 28.492  7.689   12.634  1.000 20.246 0 4   VAL   C CG1   1 ? 
ATOM   16   C  CG2   . VAL   A 1 4   ? 28.674  5.278   13.262  1.000 21.876 0 4   VAL   C CG2   1 ? 
ATOM   17   N  N     . ARG   A 1 5   ? 30.097  9.348   15.436  1.000 16.106 0 5   ARG   C N     1 ? 
ATOM   18   C  CA    . ARG   A 1 5   ? 29.890  10.690  15.952  1.000 17.153 0 5   ARG   C CA    1 ? 
ATOM   19   C  C     . ARG   A 1 5   ? 28.988  11.499  15.014  1.000 15.950 0 5   ARG   C C     1 ? 
ATOM   20   O  O     . ARG   A 1 5   ? 28.865  11.202  13.819  1.000 15.613 0 5   ARG   C O     1 ? 
ATOM   21   C  CB    . ARG   A 1 5   ? 31.233  11.393  16.206  1.000 22.406 0 5   ARG   C CB    1 ? 
ATOM   22   C  CG    . ARG   A 1 5   ? 32.104  10.670  17.228  1.000 28.802 0 5   ARG   C CG    1 ? 
ATOM   23   C  CD    . ARG   A 1 5   ? 33.149  11.536  17.905  1.000 35.299 0 5   ARG   C CD    1 ? 
ATOM   24   N  NE    . ARG   A 1 5   ? 33.982  10.803  18.864  1.000 42.899 0 5   ARG   C NE    1 ? 
ATOM   25   C  CZ    . ARG   A 1 5   ? 35.313  10.916  18.981  1.000 46.905 0 5   ARG   C CZ    1 ? 
ATOM   26   N  NH1   . ARG   A 1 5   ? 36.004  11.737  18.204  1.000 45.436 0 5   ARG   C NH1   1 ? 
ATOM   27   N  NH2   . ARG   A 1 5   ? 35.961  10.208  19.892  1.000 45.684 0 5   ARG   C NH2   1 ? 
ATOM   28   N  N     . LEU   A 1 6   ? 28.420  12.577  15.529  1.000 16.486 0 6   LEU   C N     1 ? 
ATOM   29   C  CA    . LEU   A 1 6   ? 27.409  13.351  14.816  1.000 17.205 0 6   LEU   C CA    1 ? 
ATOM   30   C  C     . LEU   A 1 6   ? 27.951  13.899  13.494  1.000 17.101 0 6   LEU   C C     1 ? 
ATOM   31   O  O     . LEU   A 1 6   ? 27.282  13.827  12.462  1.000 15.073 0 6   LEU   C O     1 ? 
ATOM   32   C  CB    . LEU   A 1 6   ? 26.926  14.487  15.721  1.000 17.103 0 6   LEU   C CB    1 ? 
ATOM   33   C  CG    . LEU   A 1 6   ? 25.825  15.374  15.161  1.000 18.348 0 6   LEU   C CG    1 ? 
ATOM   34   C  CD1   . LEU   A 1 6   ? 24.598  14.592  14.719  1.000 17.988 0 6   LEU   C CD1   1 ? 
ATOM   35   C  CD2   . LEU   A 1 6   ? 25.430  16.412  16.206  1.000 20.418 0 6   LEU   C CD2   1 ? 
ATOM   36   N  N     . LYS   A 1 7   ? 29.174  14.445  13.495  1.000 15.836 0 7   LYS   C N     1 ? 
ATOM   37   C  CA    . LYS   A 1 7   ? 29.731  15.056  12.296  1.000 16.975 0 7   LYS   C CA    1 ? 
ATOM   38   C  C     . LYS   A 1 7   ? 30.030  13.992  11.259  1.000 14.804 0 7   LYS   C C     1 ? 
ATOM   39   O  O     . LYS   A 1 7   ? 29.753  14.173  10.077  1.000 13.204 0 7   LYS   C O     1 ? 
ATOM   40   C  CB    . LYS   A 1 7   ? 31.021  15.839  12.540  1.000 19.159 0 7   LYS   C CB    1 ? 
ATOM   41   C  CG    . LYS   A 1 7   ? 30.811  17.268  13.012  1.000 24.504 0 7   LYS   C CG    1 ? 
ATOM   42   C  CD    . LYS   A 1 7   ? 32.132  18.033  13.137  1.000 27.098 0 7   LYS   C CD    1 ? 
ATOM   43   C  CE    . LYS   A 1 7   ? 32.081  19.159  14.144  1.000 31.469 0 7   LYS   C CE    1 ? 
ATOM   44   N  NZ    . LYS   A 1 7   ? 30.956  20.074  13.869  1.000 34.804 0 7   LYS   C NZ    1 ? 
ATOM   45   N  N     . GLU   A 1 8   ? 30.522  12.834  11.701  1.000 14.344 0 8   GLU   C N     1 ? 
ATOM   46   C  CA    . GLU   A 1 8   ? 30.779  11.714  10.825  1.000 15.205 0 8   GLU   C CA    1 ? 
ATOM   47   C  C     . GLU   A 1 8   ? 29.473  11.263  10.166  1.000 12.465 0 8   GLU   C C     1 ? 
ATOM   48   O  O     . GLU   A 1 8   ? 29.420  11.052  8.958   1.000 12.287 0 8   GLU   C O     1 ? 
ATOM   49   C  CB    . GLU   A 1 8   ? 31.433  10.578  11.620  1.000 17.453 0 8   GLU   C CB    1 ? 
ATOM   50   C  CG    . GLU   A 1 8   ? 31.788  9.360   10.786  1.000 21.497 0 8   GLU   C CG    1 ? 
ATOM   51   C  CD    . GLU   A 1 8   ? 32.704  9.588   9.594   1.000 26.687 0 8   GLU   C CD    1 ? 
ATOM   52   O  OE1   . GLU   A 1 8   ? 33.664  10.417  9.750   1.000 29.195 0 8   GLU   C OE1   1 ? 
ATOM   53   O  OE2   . GLU   A 1 8   ? 32.479  8.908   8.512   1.000 26.972 0 8   GLU   C OE2   1 ? 
ATOM   54   N  N     . LEU   A 1 9   ? 28.416  11.121  10.959  1.000 11.116 0 9   LEU   C N     1 ? 
ATOM   55   C  CA    . LEU   A 1 9   ? 27.129  10.687  10.414  1.000 10.206 0 9   LEU   C CA    1 ? 
ATOM   56   C  C     . LEU   A 1 9   ? 26.623  11.658  9.339   1.000 9.885  0 9   LEU   C C     1 ? 
ATOM   57   O  O     . LEU   A 1 9   ? 26.266  11.238  8.238   1.000 9.180  0 9   LEU   C O     1 ? 
ATOM   58   C  CB    . LEU   A 1 9   ? 26.129  10.569  11.563  1.000 10.616 0 9   LEU   C CB    1 ? 
ATOM   59   C  CG    . LEU   A 1 9   ? 24.713  10.166  11.147  1.000 10.940 0 9   LEU   C CG    1 ? 
ATOM   60   C  CD1   . LEU   A 1 9   ? 24.667  8.828   10.445  1.000 11.381 0 9   LEU   C CD1   1 ? 
ATOM   61   C  CD2   . LEU   A 1 9   ? 23.797  10.173  12.366  1.000 10.696 0 9   LEU   C CD2   1 ? 
ATOM   62   N  N     . GLU   A 1 10  ? 26.662  12.948  9.656   1.000 9.598  0 10  GLU   C N     1 ? 
ATOM   63   C  CA    . GLU   A 1 10  ? 26.257  13.991  8.723   1.000 10.262 0 10  GLU   C CA    1 ? 
ATOM   64   C  C     . GLU   A 1 10  ? 27.107  13.929  7.449   1.000 9.182  0 10  GLU   C C     1 ? 
ATOM   65   O  O     . GLU   A 1 10  ? 26.561  14.027  6.354   1.000 8.822  0 10  GLU   C O     1 ? 
ATOM   66   C  CB    . GLU   A 1 10  ? 26.302  15.380  9.350   1.000 11.025 0 10  GLU   C CB    1 ? 
ATOM   67   C  CG    . GLU   A 1 10  ? 25.780  16.484  8.470   1.000 11.391 0 10  GLU   C CG    1 ? 
ATOM   68   C  CD    . GLU   A 1 10  ? 25.554  17.802  9.185   1.000 12.710 0 10  GLU   C CD    1 ? 
ATOM   69   O  OE1   . GLU   A 1 10  ? 25.416  17.753  10.411  1.000 14.318 0 10  GLU   C OE1   1 ? 
ATOM   70   O  OE2   . GLU   A 1 10  ? 25.433  18.824  8.471   1.000 16.682 0 10  GLU   C OE2   1 ? 
ATOM   71   N  N     . SER   A 1 11  ? 28.429  13.735  7.570   1.000 9.788  0 11  SER   C N     1 ? 
ATOM   72   C  CA    . SER   A 1 11  ? 29.314  13.641  6.414   1.000 9.998  0 11  SER   C CA    1 ? 
ATOM   73   C  C     . SER   A 1 11  ? 28.872  12.512  5.507   1.000 10.305 0 11  SER   C C     1 ? 
ATOM   74   O  O     . SER   A 1 11  ? 28.859  12.651  4.280   1.000 9.493  0 11  SER   C O     1 ? 
ATOM   75   C  CB    . SER   A 1 11  ? 30.727  13.416  6.874   1.000 11.544 0 11  SER   C CB    1 ? 
ATOM   76   O  OG    . SER   A 1 11  ? 31.574  13.146  5.791   1.000 13.649 0 11  SER   C OG    1 ? 
ATOM   77   N  N     . ARG   A 1 12  ? 28.546  11.363  6.097   1.000 9.086  0 12  ARG   C N     1 ? 
ATOM   78   C  CA    . ARG   A 1 12  ? 28.161  10.206  5.324   1.000 9.607  0 12  ARG   C CA    1 ? 
ATOM   79   C  C     . ARG   A 1 12  ? 26.846  10.486  4.599   1.000 8.302  0 12  ARG   C C     1 ? 
ATOM   80   O  O     . ARG   A 1 12  ? 26.633  10.134  3.437   1.000 9.592  0 12  ARG   C O     1 ? 
ATOM   81   C  CB    . ARG   A 1 12  ? 28.067  8.912   6.141   1.000 10.363 0 12  ARG   C CB    1 ? 
ATOM   82   C  CG    . ARG   A 1 12  ? 29.376  8.465   6.767   1.000 12.779 0 12  ARG   C CG    1 ? 
ATOM   83   C  CD    . ARG   A 1 12  ? 29.085  7.200   7.564   1.000 13.736 0 12  ARG   C CD    1 ? 
ATOM   84   N  NE    . ARG   A 1 12  ? 30.220  6.902   8.406   1.000 17.610 0 12  ARG   C NE    1 ? 
ATOM   85   C  CZ    . ARG   A 1 12  ? 30.289  5.847   9.198   1.000 18.587 0 12  ARG   C CZ    1 ? 
ATOM   86   N  NH1   . ARG   A 1 12  ? 29.258  5.025   9.257   1.000 18.496 0 12  ARG   C NH1   1 ? 
ATOM   87   N  NH2   . ARG   A 1 12  ? 31.378  5.624   9.912   1.000 22.422 0 12  ARG   C NH2   1 ? 
ATOM   88   N  N     . LEU   A 1 13  ? 25.913  11.130  5.310   1.000 8.145  0 13  LEU   C N     1 ? 
ATOM   89   C  CA    . LEU   A 1 13  ? 24.611  11.414  4.730   1.000 8.864  0 13  LEU   C CA    1 ? 
ATOM   90   C  C     . LEU   A 1 13  ? 24.662  12.440  3.609   1.000 9.214  0 13  LEU   C C     1 ? 
ATOM   91   O  O     . LEU   A 1 13  ? 23.809  12.385  2.728   1.000 9.331  0 13  LEU   C O     1 ? 
ATOM   92   C  CB    . LEU   A 1 13  ? 23.614  11.786  5.825   1.000 9.386  0 13  LEU   C CB    1 ? 
ATOM   93   C  CG    . LEU   A 1 13  ? 23.334  10.635  6.797   1.000 9.586  0 13  LEU   C CG    1 ? 
ATOM   94   C  CD1   . LEU   A 1 13  ? 22.323  11.068  7.833   1.000 11.009 0 13  LEU   C CD1   1 ? 
ATOM   95   C  CD2   . LEU   A 1 13  ? 22.902  9.350   6.093   1.000 10.439 0 13  LEU   C CD2   1 ? 
ATOM   96   N  N     . GLN   A 1 14  ? 25.717  13.296  3.581   1.000 9.416  0 14  GLN   C N     1 ? 
ATOM   97   C  CA    . GLN   A 1 14  ? 25.958  14.183  2.442   1.000 10.218 0 14  GLN   C CA    1 ? 
ATOM   98   C  C     . GLN   A 1 14  ? 26.303  13.405  1.178   1.000 9.916  0 14  GLN   C C     1 ? 
ATOM   99   O  O     . GLN   A 1 14  ? 26.242  13.949  0.079   1.000 10.869 0 14  GLN   C O     1 ? 
ATOM   100  C  CB    . GLN   A 1 14  ? 27.091  15.194  2.705   1.000 11.653 0 14  GLN   C CB    1 ? 
ATOM   101  C  CG    . GLN   A 1 14  ? 26.762  16.227  3.777   1.000 13.503 0 14  GLN   C CG    1 ? 
ATOM   102  C  CD    . GLN   A 1 14  ? 27.916  17.154  4.093   1.000 17.109 0 14  GLN   C CD    1 ? 
ATOM   103  O  OE1   . GLN   A 1 14  ? 29.041  16.868  3.703   1.000 22.226 0 14  GLN   C OE1   1 ? 
ATOM   104  N  NE2   . GLN   A 1 14  ? 27.636  18.155  4.907   1.000 22.884 0 14  GLN   C NE2   1 ? 
ATOM   105  N  N     A GLN   A 1 15  ? 26.673  12.112  1.299   0.500 9.947  0 15  GLN   C N     1 ? 
ATOM   106  N  N     B GLN   A 1 15  ? 26.626  12.114  1.301   0.500 8.505  0 15  GLN   C N     1 ? 
ATOM   107  C  CA    A GLN   A 1 15  ? 27.062  11.299  0.150   0.500 10.767 0 15  GLN   C CA    1 ? 
ATOM   108  C  CA    B GLN   A 1 15  ? 27.038  11.321  0.160   0.500 8.207  0 15  GLN   C CA    1 ? 
ATOM   109  C  C     A GLN   A 1 15  ? 25.878  10.522  -0.440  0.500 9.719  0 15  GLN   C C     1 ? 
ATOM   110  C  C     B GLN   A 1 15  ? 25.905  10.416  -0.334  0.500 8.339  0 15  GLN   C C     1 ? 
ATOM   111  O  O     A GLN   A 1 15  ? 26.035  9.851   -1.459  0.500 10.605 0 15  GLN   C O     1 ? 
ATOM   112  O  O     B GLN   A 1 15  ? 26.125  9.547   -1.162  0.500 9.323  0 15  GLN   C O     1 ? 
ATOM   113  C  CB    A GLN   A 1 15  ? 28.144  10.262  0.488   0.500 13.175 0 15  GLN   C CB    1 ? 
ATOM   114  C  CB    B GLN   A 1 15  ? 28.292  10.536  0.549   0.500 8.195  0 15  GLN   C CB    1 ? 
ATOM   115  C  CG    A GLN   A 1 15  ? 29.281  10.779  1.343   0.500 17.015 0 15  GLN   C CG    1 ? 
ATOM   116  C  CG    B GLN   A 1 15  ? 29.458  11.450  0.841   0.500 8.855  0 15  GLN   C CG    1 ? 
ATOM   117  C  CD    A GLN   A 1 15  ? 29.787  12.116  0.878   0.500 19.090 0 15  GLN   C CD    1 ? 
ATOM   118  C  CD    B GLN   A 1 15  ? 30.604  10.659  1.408   0.500 9.175  0 15  GLN   C CD    1 ? 
ATOM   119  O  OE1   A GLN   A 1 15  ? 30.056  12.316  -0.303  0.500 21.898 0 15  GLN   C OE1   1 ? 
ATOM   120  O  OE1   B GLN   A 1 15  ? 31.264  9.910   0.691   0.500 11.500 0 15  GLN   C OE1   1 ? 
ATOM   121  N  NE2   A GLN   A 1 15  ? 29.960  13.035  1.812   0.500 20.857 0 15  GLN   C NE2   1 ? 
ATOM   122  N  NE2   B GLN   A 1 15  ? 30.883  10.887  2.671   0.500 9.421  0 15  GLN   C NE2   1 ? 
ATOM   123  N  N     . VAL   A 1 16  ? 24.691  10.659  0.160   1.000 8.733  0 16  VAL   C N     1 ? 
ATOM   124  C  CA    . VAL   A 1 16  ? 23.501  10.014  -0.369  1.000 8.433  0 16  VAL   C CA    1 ? 
ATOM   125  C  C     . VAL   A 1 16  ? 23.016  10.835  -1.559  1.000 8.992  0 16  VAL   C C     1 ? 
ATOM   126  O  O     . VAL   A 1 16  ? 22.783  12.034  -1.411  1.000 9.031  0 16  VAL   C O     1 ? 
ATOM   127  C  CB    . VAL   A 1 16  ? 22.413  9.859   0.710   1.000 9.300  0 16  VAL   C CB    1 ? 
ATOM   128  C  CG1   . VAL   A 1 16  ? 21.149  9.291   0.139   1.000 9.153  0 16  VAL   C CG1   1 ? 
ATOM   129  C  CG2   . VAL   A 1 16  ? 22.900  8.984   1.831   1.000 9.399  0 16  VAL   C CG2   1 ? 
ATOM   130  N  N     . ASP   A 1 17  ? 22.892  10.247  -2.731  1.000 9.006  0 17  ASP   C N     1 ? 
ATOM   131  C  CA    . ASP   A 1 17  ? 22.428  10.938  -3.921  1.000 10.573 0 17  ASP   C CA    1 ? 
ATOM   132  C  C     . ASP   A 1 17  ? 20.931  11.154  -3.869  1.000 10.606 0 17  ASP   C C     1 ? 
ATOM   133  O  O     . ASP   A 1 17  ? 20.184  10.351  -3.309  1.000 9.621  0 17  ASP   C O     1 ? 
ATOM   134  C  CB    . ASP   A 1 17  ? 22.776  10.153  -5.178  1.000 13.261 0 17  ASP   C CB    1 ? 
ATOM   135  C  CG    . ASP   A 1 17  ? 24.252  10.109  -5.510  1.000 16.266 0 17  ASP   C CG    1 ? 
ATOM   136  O  OD1   . ASP   A 1 17  ? 24.982  10.966  -5.016  1.000 16.994 0 17  ASP   C OD1   1 ? 
ATOM   137  O  OD2   . ASP   A 1 17  ? 24.652  9.157   -6.246  1.000 20.156 0 17  ASP   C OD2   1 ? 
ATOM   138  N  N     . GLY   A 1 18  ? 20.512  12.293  -4.422  1.000 9.440  0 18  GLY   C N     1 ? 
ATOM   139  C  CA    . GLY   A 1 18  ? 19.111  12.673  -4.412  1.000 9.669  0 18  GLY   C CA    1 ? 
ATOM   140  C  C     . GLY   A 1 18  ? 18.302  12.216  -5.613  1.000 9.665  0 18  GLY   C C     1 ? 
ATOM   141  O  O     . GLY   A 1 18  ? 18.668  11.310  -6.355  1.000 10.993 0 18  GLY   C O     1 ? 
ATOM   142  N  N     . PHE   A 1 19  ? 17.121  12.839  -5.755  1.000 10.492 0 19  PHE   C N     1 ? 
ATOM   143  C  CA    . PHE   A 1 19  ? 16.190  12.487  -6.805  1.000 11.991 0 19  PHE   C CA    1 ? 
ATOM   144  C  C     . PHE   A 1 19  ? 16.703  12.961  -8.167  1.000 14.019 0 19  PHE   C C     1 ? 
ATOM   145  O  O     . PHE   A 1 19  ? 17.078  14.107  -8.322  1.000 15.477 0 19  PHE   C O     1 ? 
ATOM   146  C  CB    . PHE   A 1 19  ? 14.798  13.080  -6.515  1.000 10.684 0 19  PHE   C CB    1 ? 
ATOM   147  C  CG    . PHE   A 1 19  ? 14.104  12.664  -5.238  1.000 10.077 0 19  PHE   C CG    1 ? 
ATOM   148  C  CD1   . PHE   A 1 19  ? 14.451  13.235  -4.027  1.000 9.560  0 19  PHE   C CD1   1 ? 
ATOM   149  C  CD2   . PHE   A 1 19  ? 13.196  11.614  -5.206  1.000 9.105  0 19  PHE   C CD2   1 ? 
ATOM   150  C  CE1   . PHE   A 1 19  ? 13.790  12.896  -2.856  1.000 9.159  0 19  PHE   C CE1   1 ? 
ATOM   151  C  CE2   . PHE   A 1 19  ? 12.553  11.280  -4.031  1.000 9.433  0 19  PHE   C CE2   1 ? 
ATOM   152  C  CZ    . PHE   A 1 19  ? 12.864  11.860  -2.855  1.000 10.231 0 19  PHE   C CZ    1 ? 
ATOM   153  N  N     . GLU   A 1 20  ? 16.569  12.111  -9.181  1.000 17.869 0 20  GLU   C N     1 ? 
ATOM   154  C  CA    . GLU   A 1 20  ? 16.953  12.462  -10.536 1.000 19.000 0 20  GLU   C CA    1 ? 
ATOM   155  C  C     . GLU   A 1 20  ? 15.971  13.440  -11.183 1.000 22.605 0 20  GLU   C C     1 ? 
ATOM   156  O  O     . GLU   A 1 20  ? 16.395  14.425  -11.775 1.000 26.834 0 20  GLU   C O     1 ? 
ATOM   157  C  CB    . GLU   A 1 20  ? 17.207  11.163  -11.293 1.000 22.840 0 20  GLU   C CB    1 ? 
ATOM   158  C  CG    . GLU   A 1 20  ? 18.677  10.802  -11.191 1.000 30.226 0 20  GLU   C CG    1 ? 
ATOM   159  C  CD    . GLU   A 1 20  ? 19.055  9.342   -11.296 1.000 37.342 0 20  GLU   C CD    1 ? 
ATOM   160  O  OE1   . GLU   A 1 20  ? 18.525  8.647   -12.183 1.000 43.756 0 20  GLU   C OE1   1 ? 
ATOM   161  O  OE2   . GLU   A 1 20  ? 19.914  8.926   -10.497 1.000 37.057 0 20  GLU   C OE2   1 ? 
ATOM   162  N  N     . LYS   A 1 21  ? 14.678  13.197  -11.083 1.000 20.032 0 21  LYS   C N     1 ? 
ATOM   163  C  CA    . LYS   A 1 21  ? 13.719  14.199  -11.526 1.000 22.185 0 21  LYS   C CA    1 ? 
ATOM   164  C  C     . LYS   A 1 21  ? 12.604  14.242  -10.485 1.000 17.258 0 21  LYS   C C     1 ? 
ATOM   165  O  O     . LYS   A 1 21  ? 11.618  13.482  -10.506 1.000 19.726 0 21  LYS   C O     1 ? 
ATOM   166  C  CB    . LYS   A 1 21  ? 13.181  13.942  -12.931 1.000 25.710 0 21  LYS   C CB    1 ? 
ATOM   167  C  CG    . LYS   A 1 21  ? 14.167  14.164  -14.075 1.000 31.551 0 21  LYS   C CG    1 ? 
ATOM   168  C  CD    . LYS   A 1 21  ? 13.615  13.780  -15.443 1.000 40.939 0 21  LYS   C CD    1 ? 
ATOM   169  C  CE    . LYS   A 1 21  ? 14.687  13.508  -16.485 1.000 43.813 0 21  LYS   C CE    1 ? 
ATOM   170  N  NZ    . LYS   A 1 21  ? 15.243  12.141  -16.351 1.000 47.036 0 21  LYS   C NZ    1 ? 
ATOM   171  N  N     . PRO   A 1 22  ? 12.804  15.104  -9.493  1.000 14.882 0 22  PRO   C N     1 ? 
ATOM   172  C  CA    . PRO   A 1 22  ? 11.897  15.111  -8.344  1.000 13.416 0 22  PRO   C CA    1 ? 
ATOM   173  C  C     . PRO   A 1 22  ? 10.497  15.491  -8.783  1.000 15.053 0 22  PRO   C C     1 ? 
ATOM   174  O  O     . PRO   A 1 22  ? 10.325  16.488  -9.483  1.000 16.332 0 22  PRO   C O     1 ? 
ATOM   175  C  CB    . PRO   A 1 22  ? 12.480  16.143  -7.391  1.000 15.829 0 22  PRO   C CB    1 ? 
ATOM   176  C  CG    . PRO   A 1 22  ? 13.501  16.946  -8.229  1.000 16.896 0 22  PRO   C CG    1 ? 
ATOM   177  C  CD    . PRO   A 1 22  ? 13.931  16.033  -9.346  1.000 16.437 0 22  PRO   C CD    1 ? 
ATOM   178  N  N     . LYS   A 1 23  ? 9.513   14.747  -8.281  1.000 11.580 0 23  LYS   C N     1 ? 
ATOM   179  C  CA    . LYS   A 1 23  ? 8.108   14.942  -8.579  1.000 12.870 0 23  LYS   C CA    1 ? 
ATOM   180  C  C     . LYS   A 1 23  ? 7.501   15.880  -7.560  1.000 12.808 0 23  LYS   C C     1 ? 
ATOM   181  O  O     . LYS   A 1 23  ? 7.265   15.543  -6.393  1.000 12.695 0 23  LYS   C O     1 ? 
ATOM   182  C  CB    . LYS   A 1 23  ? 7.400   13.596  -8.598  1.000 12.498 0 23  LYS   C CB    1 ? 
ATOM   183  C  CG    . LYS   A 1 23  ? 7.911   12.667  -9.673  1.000 12.932 0 23  LYS   C CG    1 ? 
ATOM   184  C  CD    . LYS   A 1 23  ? 7.260   11.317  -9.612  1.000 14.717 0 23  LYS   C CD    1 ? 
ATOM   185  C  CE    . LYS   A 1 23  ? 7.719   10.392  -10.717 1.000 16.748 0 23  LYS   C CE    1 ? 
ATOM   186  N  NZ    . LYS   A 1 23  ? 9.146   9.998   -10.566 1.000 18.984 0 23  LYS   C NZ    1 ? 
ATOM   187  N  N     . LEU   A 1 24  ? 7.208   17.089  -8.024  1.000 13.361 0 24  LEU   C N     1 ? 
ATOM   188  C  CA    . LEU   A 1 24  ? 6.663   18.159  -7.230  1.000 12.558 0 24  LEU   C CA    1 ? 
ATOM   189  C  C     . LEU   A 1 24  ? 5.392   17.744  -6.490  1.000 10.730 0 24  LEU   C C     1 ? 
ATOM   190  O  O     . LEU   A 1 24  ? 5.265   18.079  -5.318  1.000 11.704 0 24  LEU   C O     1 ? 
ATOM   191  C  CB    . LEU   A 1 24  ? 6.393   19.344  -8.162  1.000 15.853 0 24  LEU   C CB    1 ? 
ATOM   192  C  CG    . LEU   A 1 24  ? 5.759   20.572  -7.533  1.000 14.589 0 24  LEU   C CG    1 ? 
ATOM   193  C  CD1   . LEU   A 1 24  ? 6.698   21.213  -6.528  1.000 17.384 0 24  LEU   C CD1   1 ? 
ATOM   194  C  CD2   . LEU   A 1 24  ? 5.386   21.561  -8.633  1.000 14.315 0 24  LEU   C CD2   1 ? 
ATOM   195  N  N     . LEU   A 1 25  ? 4.485   17.041  -7.159  1.000 10.895 0 25  LEU   C N     1 ? 
ATOM   196  C  CA    . LEU   A 1 25  ? 3.212   16.676  -6.547  1.000 11.124 0 25  LEU   C CA    1 ? 
ATOM   197  C  C     . LEU   A 1 25  ? 3.378   15.763  -5.335  1.000 11.173 0 25  LEU   C C     1 ? 
ATOM   198  O  O     . LEU   A 1 25  ? 2.473   15.706  -4.522  1.000 12.501 0 25  LEU   C O     1 ? 
ATOM   199  C  CB    . LEU   A 1 25  ? 2.280   16.067  -7.578  1.000 11.900 0 25  LEU   C CB    1 ? 
ATOM   200  C  CG    . LEU   A 1 25  ? 1.816   17.033  -8.676  1.000 13.821 0 25  LEU   C CG    1 ? 
ATOM   201  C  CD1   . LEU   A 1 25  ? 0.926   16.327  -9.664  1.000 14.578 0 25  LEU   C CD1   1 ? 
ATOM   202  C  CD2   . LEU   A 1 25  ? 1.122   18.250  -8.067  1.000 16.376 0 25  LEU   C CD2   1 ? 
ATOM   203  N  N     . LEU   A 1 26  ? 4.477   15.015  -5.288  1.000 9.724  0 26  LEU   C N     1 ? 
ATOM   204  C  CA    . LEU   A 1 26  ? 4.780   14.104  -4.203  1.000 8.880  0 26  LEU   C CA    1 ? 
ATOM   205  C  C     . LEU   A 1 26  ? 5.700   14.722  -3.173  1.000 9.503  0 26  LEU   C C     1 ? 
ATOM   206  O  O     . LEU   A 1 26  ? 6.109   14.058  -2.231  1.000 9.726  0 26  LEU   C O     1 ? 
ATOM   207  C  CB    . LEU   A 1 26  ? 5.390   12.804  -4.756  1.000 9.347  0 26  LEU   C CB    1 ? 
ATOM   208  C  CG    . LEU   A 1 26  ? 4.525   12.023  -5.743  1.000 10.345 0 26  LEU   C CG    1 ? 
ATOM   209  C  CD1   . LEU   A 1 26  ? 5.258   10.768  -6.178  1.000 10.290 0 26  LEU   C CD1   1 ? 
ATOM   210  C  CD2   . LEU   A 1 26  ? 3.160   11.690  -5.165  1.000 10.603 0 26  LEU   C CD2   1 ? 
ATOM   211  N  N     . GLU   A 1 27  ? 6.050   16.018  -3.307  1.000 8.523  0 27  GLU   C N     1 ? 
ATOM   212  C  CA    . GLU   A 1 27  ? 6.906   16.733  -2.383  1.000 10.037 0 27  GLU   C CA    1 ? 
ATOM   213  C  C     . GLU   A 1 27  ? 8.241   15.984  -2.213  1.000 8.411  0 27  GLU   C C     1 ? 
ATOM   214  O  O     . GLU   A 1 27  ? 8.727   15.751  -1.116  1.000 10.571 0 27  GLU   C O     1 ? 
ATOM   215  C  CB    . GLU   A 1 27  ? 6.203   17.027  -1.055  1.000 10.753 0 27  GLU   C CB    1 ? 
ATOM   216  C  CG    . GLU   A 1 27  ? 5.009   17.946  -1.273  1.000 12.658 0 27  GLU   C CG    1 ? 
ATOM   217  C  CD    . GLU   A 1 27  ? 4.118   18.210  -0.077  1.000 15.847 0 27  GLU   C CD    1 ? 
ATOM   218  O  OE1   . GLU   A 1 27  ? 4.651   18.551  0.972   1.000 15.992 0 27  GLU   C OE1   1 ? 
ATOM   219  O  OE2   . GLU   A 1 27  ? 2.915   17.778  -0.195  1.000 21.568 0 27  GLU   C OE2   1 ? 
ATOM   220  N  N     . GLN   A 1 28  ? 8.867   15.712  -3.342  1.000 8.495  0 28  GLN   C N     1 ? 
ATOM   221  C  CA    . GLN   A 1 28  ? 10.135  14.990  -3.370  1.000 9.503  0 28  GLN   C CA    1 ? 
ATOM   222  C  C     . GLN   A 1 28  ? 11.305  15.939  -3.162  1.000 9.051  0 28  GLN   C C     1 ? 
ATOM   223  O  O     . GLN   A 1 28  ? 11.684  16.722  -4.070  1.000 11.757 0 28  GLN   C O     1 ? 
ATOM   224  C  CB    . GLN   A 1 28  ? 10.316  14.181  -4.655  1.000 9.481  0 28  GLN   C CB    1 ? 
ATOM   225  C  CG    . GLN   A 1 28  ? 9.293   13.065  -4.750  1.000 9.660  0 28  GLN   C CG    1 ? 
ATOM   226  C  CD    . GLN   A 1 28  ? 9.631   12.097  -5.839  1.000 8.782  0 28  GLN   C CD    1 ? 
ATOM   227  O  OE1   . GLN   A 1 28  ? 10.199  12.437  -6.879  1.000 9.495  0 28  GLN   C OE1   1 ? 
ATOM   228  N  NE2   . GLN   A 1 28  ? 9.204   10.866  -5.645  1.000 8.991  0 28  GLN   C NE2   1 ? 
ATOM   229  N  N     . TYR   A 1 29  ? 11.926  15.865  -1.988  1.000 9.331  0 29  TYR   C N     1 ? 
ATOM   230  C  CA    . TYR   A 1 29  ? 13.238  16.448  -1.720  1.000 9.737  0 29  TYR   C CA    1 ? 
ATOM   231  C  C     . TYR   A 1 29  ? 13.912  15.545  -0.701  1.000 10.517 0 29  TYR   C C     1 ? 
ATOM   232  O  O     . TYR   A 1 29  ? 13.229  14.948  0.144   1.000 11.887 0 29  TYR   C O     1 ? 
ATOM   233  C  CB    . TYR   A 1 29  ? 13.115  17.917  -1.274  1.000 9.740  0 29  TYR   C CB    1 ? 
ATOM   234  C  CG    . TYR   A 1 29  ? 12.313  18.100  -0.015  1.000 9.057  0 29  TYR   C CG    1 ? 
ATOM   235  C  CD1   . TYR   A 1 29  ? 12.866  17.977  1.250   1.000 10.403 0 29  TYR   C CD1   1 ? 
ATOM   236  C  CD2   . TYR   A 1 29  ? 10.950  18.434  -0.085  1.000 10.544 0 29  TYR   C CD2   1 ? 
ATOM   237  C  CE1   . TYR   A 1 29  ? 12.122  18.069  2.418   1.000 10.460 0 29  TYR   C CE1   1 ? 
ATOM   238  C  CE2   . TYR   A 1 29  ? 10.193  18.539  1.071   1.000 10.263 0 29  TYR   C CE2   1 ? 
ATOM   239  C  CZ    . TYR   A 1 29  ? 10.782  18.413  2.322   1.000 11.182 0 29  TYR   C CZ    1 ? 
ATOM   240  O  OH    . TYR   A 1 29  ? 10.011  18.476  3.475   1.000 14.098 0 29  TYR   C OH    1 ? 
ATOM   241  N  N     . PRO   A 1 30  ? 15.236  15.369  -0.726  1.000 9.972  0 30  PRO   C N     1 ? 
ATOM   242  C  CA    . PRO   A 1 30  ? 15.902  14.536  0.259   1.000 10.133 0 30  PRO   C CA    1 ? 
ATOM   243  C  C     . PRO   A 1 30  ? 15.827  15.165  1.630   1.000 9.664  0 30  PRO   C C     1 ? 
ATOM   244  O  O     . PRO   A 1 30  ? 15.943  16.377  1.753   1.000 9.877  0 30  PRO   C O     1 ? 
ATOM   245  C  CB    . PRO   A 1 30  ? 17.336  14.422  -0.243  1.000 10.623 0 30  PRO   C CB    1 ? 
ATOM   246  C  CG    . PRO   A 1 30  ? 17.285  14.846  -1.665  1.000 11.873 0 30  PRO   C CG    1 ? 
ATOM   247  C  CD    . PRO   A 1 30  ? 16.192  15.904  -1.705  1.000 9.466  0 30  PRO   C CD    1 ? 
ATOM   248  N  N     . THR   A 1 31  ? 15.748  14.352  2.673   1.000 9.609  0 31  THR   C N     1 ? 
ATOM   249  C  CA    . THR   A 1 31  ? 15.876  14.902  4.012   1.000 9.057  0 31  THR   C CA    1 ? 
ATOM   250  C  C     . THR   A 1 31  ? 17.275  15.543  4.100   1.000 8.460  0 31  THR   C C     1 ? 
ATOM   251  O  O     . THR   A 1 31  ? 18.282  14.920  3.716   1.000 9.068  0 31  THR   C O     1 ? 
ATOM   252  C  CB    . THR   A 1 31  ? 15.705  13.815  5.078   1.000 9.548  0 31  THR   C CB    1 ? 
ATOM   253  O  OG1   . THR   A 1 31  ? 14.389  13.269  4.984   1.000 9.116  0 31  THR   C OG1   1 ? 
ATOM   254  C  CG2   . THR   A 1 31  ? 15.978  14.378  6.455   1.000 9.033  0 31  THR   C CG2   1 ? 
ATOM   255  N  N     . ARG   A 1 32  ? 17.369  16.771  4.593   1.000 8.748  0 32  ARG   C N     1 ? 
ATOM   256  C  CA    . ARG   A 1 32  ? 18.619  17.503  4.515   1.000 9.426  0 32  ARG   C CA    1 ? 
ATOM   257  C  C     . ARG   A 1 32  ? 19.633  16.877  5.476   1.000 9.154  0 32  ARG   C C     1 ? 
ATOM   258  O  O     . ARG   A 1 32  ? 19.293  16.422  6.560   1.000 9.815  0 32  ARG   C O     1 ? 
ATOM   259  C  CB    . ARG   A 1 32  ? 18.447  18.989  4.807   1.000 11.278 0 32  ARG   C CB    1 ? 
ATOM   260  C  CG    . ARG   A 1 32  ? 17.759  19.786  3.719   1.000 14.123 0 32  ARG   C CG    1 ? 
ATOM   261  C  CD    . ARG   A 1 32  ? 16.475  19.320  3.115   1.000 16.357 0 32  ARG   C CD    1 ? 
ATOM   262  N  NE    . ARG   A 1 32  ? 16.064  20.246  2.054   1.000 13.453 0 32  ARG   C NE    1 ? 
ATOM   263  C  CZ    . ARG   A 1 32  ? 16.128  20.071  0.744   1.000 12.179 0 32  ARG   C CZ    1 ? 
ATOM   264  N  NH1   . ARG   A 1 32  ? 16.584  18.964  0.192   1.000 14.240 0 32  ARG   C NH1   1 ? 
ATOM   265  N  NH2   . ARG   A 1 32  ? 15.553  20.958  -0.052  1.000 13.092 0 32  ARG   C NH2   1 ? 
ATOM   266  N  N     . PRO   A 1 33  ? 20.922  16.805  5.109   1.000 9.725  0 33  PRO   C N     1 ? 
ATOM   267  C  CA    . PRO   A 1 33  ? 21.866  16.028  5.912   1.000 9.886  0 33  PRO   C CA    1 ? 
ATOM   268  C  C     . PRO   A 1 33  ? 21.964  16.441  7.375   1.000 9.274  0 33  PRO   C C     1 ? 
ATOM   269  O  O     . PRO   A 1 33  ? 22.009  15.572  8.241   1.000 9.856  0 33  PRO   C O     1 ? 
ATOM   270  C  CB    . PRO   A 1 33  ? 23.200  16.181  5.194   1.000 10.546 0 33  PRO   C CB    1 ? 
ATOM   271  C  CG    . PRO   A 1 33  ? 22.749  16.381  3.772   1.000 12.085 0 33  PRO   C CG    1 ? 
ATOM   272  C  CD    . PRO   A 1 33  ? 21.527  17.274  3.857   1.000 11.279 0 33  PRO   C CD    1 ? 
ATOM   273  N  N     . HIS   A 1 34  ? 21.905  17.744  7.669   1.000 9.666  0 34  HIS   C N     1 ? 
ATOM   274  C  CA    . HIS   A 1 34  ? 22.025  18.164  9.054   1.000 9.966  0 34  HIS   C CA    1 ? 
ATOM   275  C  C     . HIS   A 1 34  ? 20.760  17.774  9.838   1.000 9.979  0 34  HIS   C C     1 ? 
ATOM   276  O  O     . HIS   A 1 34  ? 20.832  17.488  11.029  1.000 10.682 0 34  HIS   C O     1 ? 
ATOM   277  C  CB    . HIS   A 1 34  ? 22.272  19.676  9.160   1.000 11.878 0 34  HIS   C CB    1 ? 
ATOM   278  C  CG    . HIS   A 1 34  ? 22.588  20.123  10.528  1.000 14.589 0 34  HIS   C CG    1 ? 
ATOM   279  N  ND1   . HIS   A 1 34  ? 23.661  19.652  11.248  1.000 16.075 0 34  HIS   C ND1   1 ? 
ATOM   280  C  CD2   . HIS   A 1 34  ? 21.956  21.015  11.294  1.000 18.868 0 34  HIS   C CD2   1 ? 
ATOM   281  C  CE1   . HIS   A 1 34  ? 23.644  20.257  12.444  1.000 21.311 0 34  HIS   C CE1   1 ? 
ATOM   282  N  NE2   . HIS   A 1 34  ? 22.627  21.075  12.485  1.000 19.579 0 34  HIS   C NE2   1 ? 
ATOM   283  N  N     . ILE   A 1 35  ? 19.592  17.858  9.196   1.000 9.275  0 35  ILE   C N     1 ? 
ATOM   284  C  CA    . ILE   A 1 35  ? 18.325  17.426  9.789   1.000 8.568  0 35  ILE   C CA    1 ? 
ATOM   285  C  C     . ILE   A 1 35  ? 18.349  15.931  10.106  1.000 8.472  0 35  ILE   C C     1 ? 
ATOM   286  O  O     . ILE   A 1 35  ? 18.065  15.524  11.240  1.000 8.855  0 35  ILE   C O     1 ? 
ATOM   287  C  CB    . ILE   A 1 35  ? 17.141  17.770  8.870   1.000 9.585  0 35  ILE   C CB    1 ? 
ATOM   288  C  CG1   . ILE   A 1 35  ? 17.054  19.281  8.648   1.000 10.153 0 35  ILE   C CG1   1 ? 
ATOM   289  C  CG2   . ILE   A 1 35  ? 15.853  17.170  9.406   1.000 9.597  0 35  ILE   C CG2   1 ? 
ATOM   290  C  CD1   . ILE   A 1 35  ? 16.578  20.100  9.826   1.000 11.417 0 35  ILE   C CD1   1 ? 
ATOM   291  N  N     . ALA   A 1 36  ? 18.726  15.151  9.123   1.000 8.855  0 36  ALA   C N     1 ? 
ATOM   292  C  CA    . ALA   A 1 36  ? 18.746  13.705  9.291   1.000 7.996  0 36  ALA   C CA    1 ? 
ATOM   293  C  C     . ALA   A 1 36  ? 19.755  13.267  10.359  1.000 8.733  0 36  ALA   C C     1 ? 
ATOM   294  O  O     . ALA   A 1 36  ? 19.471  12.419  11.207  1.000 8.341  0 36  ALA   C O     1 ? 
ATOM   295  C  CB    . ALA   A 1 36  ? 19.101  13.030  7.968   1.000 8.218  0 36  ALA   C CB    1 ? 
ATOM   296  N  N     . ALA   A 1 37  ? 20.953  13.853  10.314  1.000 8.001  0 37  ALA   C N     1 ? 
ATOM   297  C  CA    . ALA   A 1 37  ? 21.975  13.494  11.286  1.000 9.034  0 37  ALA   C CA    1 ? 
ATOM   298  C  C     . ALA   A 1 37  ? 21.529  13.811  12.702  1.000 9.709  0 37  ALA   C C     1 ? 
ATOM   299  O  O     . ALA   A 1 37  ? 21.647  12.947  13.558  1.000 10.496 0 37  ALA   C O     1 ? 
ATOM   300  C  CB    . ALA   A 1 37  ? 23.261  14.213  10.957  1.000 9.584  0 37  ALA   C CB    1 ? 
ATOM   301  N  N     . CYS   A 1 38  ? 21.012  15.017  12.947  1.000 9.999  0 38  CYS   C N     1 ? 
ATOM   302  C  CA    . CYS   A 1 38  ? 20.644  15.314  14.322  1.000 10.387 0 38  CYS   C CA    1 ? 
ATOM   303  C  C     . CYS   A 1 38  ? 19.479  14.445  14.792  1.000 10.777 0 38  CYS   C C     1 ? 
ATOM   304  O  O     . CYS   A 1 38  ? 19.457  13.958  15.926  1.000 11.462 0 38  CYS   C O     1 ? 
ATOM   305  C  CB    . CYS   A 1 38  ? 20.371  16.807  14.423  1.000 12.545 0 38  CYS   C CB    1 ? 
ATOM   306  S  SG    . CYS   A 1 38  ? 21.875  17.830  14.269  1.000 18.981 0 38  CYS   C SG    1 ? 
ATOM   307  N  N     . MET   A 1 39  ? 18.511  14.222  13.925  1.000 9.042  0 39  MET   C N     1 ? 
ATOM   308  C  CA    . MET   A 1 39  ? 17.335  13.412  14.212  1.000 9.244  0 39  MET   C CA    1 ? 
ATOM   309  C  C     . MET   A 1 39  ? 17.756  11.967  14.554  1.000 9.280  0 39  MET   C C     1 ? 
ATOM   310  O  O     . MET   A 1 39  ? 17.436  11.469  15.624  1.000 9.646  0 39  MET   C O     1 ? 
ATOM   311  C  CB    . MET   A 1 39  ? 16.402  13.446  12.997  1.000 10.859 0 39  MET   C CB    1 ? 
ATOM   312  C  CG    . MET   A 1 39  ? 15.188  12.548  13.051  1.000 10.728 0 39  MET   C CG    1 ? 
ATOM   313  S  SD    . MET   A 1 39  ? 14.097  12.898  11.647  1.000 13.065 0 39  MET   C SD    1 ? 
ATOM   314  C  CE    . MET   A 1 39  ? 12.749  11.758  11.870  1.000 13.151 0 39  MET   C CE    1 ? 
ATOM   315  N  N     . LEU   A 1 40  ? 18.510  11.321  13.670  1.000 7.882  0 40  LEU   C N     1 ? 
ATOM   316  C  CA    . LEU   A 1 40  ? 18.908  9.922   13.895  1.000 8.407  0 40  LEU   C CA    1 ? 
ATOM   317  C  C     . LEU   A 1 40  ? 19.871  9.800   15.080  1.000 8.356  0 40  LEU   C C     1 ? 
ATOM   318  O  O     . LEU   A 1 40  ? 19.798  8.832   15.852  1.000 8.186  0 40  LEU   C O     1 ? 
ATOM   319  C  CB    . LEU   A 1 40  ? 19.569  9.375   12.629  1.000 7.776  0 40  LEU   C CB    1 ? 
ATOM   320  C  CG    . LEU   A 1 40  ? 18.662  9.300   11.391  1.000 8.433  0 40  LEU   C CG    1 ? 
ATOM   321  C  CD1   . LEU   A 1 40  ? 19.500  8.864   10.205  1.000 8.224  0 40  LEU   C CD1   1 ? 
ATOM   322  C  CD2   . LEU   A 1 40  ? 17.447  8.378   11.589  1.000 9.320  0 40  LEU   C CD2   1 ? 
ATOM   323  N  N     . TYR   A 1 41  ? 20.819  10.748  15.222  1.000 8.472  0 41  TYR   C N     1 ? 
ATOM   324  C  CA    . TYR   A 1 41  ? 21.720  10.668  16.364  1.000 10.055 0 41  TYR   C CA    1 ? 
ATOM   325  C  C     . TYR   A 1 41  ? 20.937  10.703  17.660  1.000 9.312  0 41  TYR   C C     1 ? 
ATOM   326  O  O     . TYR   A 1 41  ? 21.255  9.981   18.610  1.000 11.174 0 41  TYR   C O     1 ? 
ATOM   327  C  CB    . TYR   A 1 41  ? 22.717  11.821  16.282  1.000 11.003 0 41  TYR   C CB    1 ? 
ATOM   328  C  CG    . TYR   A 1 41  ? 23.866  11.749  17.252  1.000 11.596 0 41  TYR   C CG    1 ? 
ATOM   329  C  CD1   . TYR   A 1 41  ? 23.716  12.252  18.528  1.000 14.788 0 41  TYR   C CD1   1 ? 
ATOM   330  C  CD2   . TYR   A 1 41  ? 25.051  11.118  16.944  1.000 12.281 0 41  TYR   C CD2   1 ? 
ATOM   331  C  CE1   . TYR   A 1 41  ? 24.731  12.205  19.466  1.000 16.080 0 41  TYR   C CE1   1 ? 
ATOM   332  C  CE2   . TYR   A 1 41  ? 26.089  11.052  17.865  1.000 15.280 0 41  TYR   C CE2   1 ? 
ATOM   333  C  CZ    . TYR   A 1 41  ? 25.894  11.547  19.139  1.000 16.558 0 41  TYR   C CZ    1 ? 
ATOM   334  O  OH    . TYR   A 1 41  ? 26.900  11.458  20.085  1.000 22.101 0 41  TYR   C OH    1 ? 
ATOM   335  N  N     . THR   A 1 42  ? 19.888  11.539  17.749  1.000 9.350  0 42  THR   C N     1 ? 
ATOM   336  C  CA    . THR   A 1 42  ? 19.067  11.583  18.949  1.000 10.246 0 42  THR   C CA    1 ? 
ATOM   337  C  C     . THR   A 1 42  ? 18.306  10.271  19.147  1.000 10.480 0 42  THR   C C     1 ? 
ATOM   338  O  O     . THR   A 1 42  ? 18.232  9.766   20.264  1.000 10.158 0 42  THR   C O     1 ? 
ATOM   339  C  CB    . THR   A 1 42  ? 18.129  12.781  18.878  1.000 12.283 0 42  THR   C CB    1 ? 
ATOM   340  O  OG1   . THR   A 1 42  ? 18.921  13.991  18.873  1.000 13.820 0 42  THR   C OG1   1 ? 
ATOM   341  C  CG2   . THR   A 1 42  ? 17.176  12.759  20.045  1.000 14.478 0 42  THR   C CG2   1 ? 
ATOM   342  N  N     . ILE   A 1 43  ? 17.654  9.780   18.094  1.000 9.544  0 43  ILE   C N     1 ? 
ATOM   343  C  CA    . ILE   A 1 43  ? 16.897  8.555   18.193  1.000 8.939  0 43  ILE   C CA    1 ? 
ATOM   344  C  C     . ILE   A 1 43  ? 17.779  7.457   18.761  1.000 10.025 0 43  ILE   C C     1 ? 
ATOM   345  O  O     . ILE   A 1 43  ? 17.312  6.697   19.620  1.000 9.867  0 43  ILE   C O     1 ? 
ATOM   346  C  CB    . ILE   A 1 43  ? 16.274  8.183   16.829  1.000 8.505  0 43  ILE   C CB    1 ? 
ATOM   347  C  CG1   . ILE   A 1 43  ? 15.257  9.238   16.389  1.000 8.444  0 43  ILE   C CG1   1 ? 
ATOM   348  C  CG2   . ILE   A 1 43  ? 15.659  6.785   16.913  1.000 9.471  0 43  ILE   C CG2   1 ? 
ATOM   349  C  CD1   . ILE   A 1 43  ? 14.814  9.134   14.980  1.000 8.982  0 43  ILE   C CD1   1 ? 
ATOM   350  N  N     . HIS   A 1 44  ? 18.993  7.330   18.249  1.000 9.558  0 44  HIS   C N     1 ? 
ATOM   351  C  CA    . HIS   A 1 44  ? 19.915  6.299   18.723  1.000 10.049 0 44  HIS   C CA    1 ? 
ATOM   352  C  C     . HIS   A 1 44  ? 20.472  6.570   20.129  1.000 11.094 0 44  HIS   C C     1 ? 
ATOM   353  O  O     . HIS   A 1 44  ? 20.326  5.719   21.006  1.000 11.590 0 44  HIS   C O     1 ? 
ATOM   354  C  CB    . HIS   A 1 44  ? 21.055  6.122   17.734  1.000 10.644 0 44  HIS   C CB    1 ? 
ATOM   355  C  CG    . HIS   A 1 44  ? 22.099  5.149   18.155  1.000 11.194 0 44  HIS   C CG    1 ? 
ATOM   356  N  ND1   . HIS   A 1 44  ? 21.802  3.861   18.543  1.000 11.772 0 44  HIS   C ND1   1 ? 
ATOM   357  C  CD2   . HIS   A 1 44  ? 23.434  5.309   18.256  1.000 12.902 0 44  HIS   C CD2   1 ? 
ATOM   358  C  CE1   . HIS   A 1 44  ? 22.959  3.262   18.858  1.000 13.546 0 44  HIS   C CE1   1 ? 
ATOM   359  N  NE2   . HIS   A 1 44  ? 23.955  4.122   18.664  1.000 13.761 0 44  HIS   C NE2   1 ? 
ATOM   360  N  N     . ASN   A 1 45  ? 21.053  7.759   20.336  1.000 10.816 0 45  ASN   C N     1 ? 
ATOM   361  C  CA    . ASN   A 1 45  ? 21.859  7.959   21.539  1.000 10.910 0 45  ASN   C CA    1 ? 
ATOM   362  C  C     . ASN   A 1 45  ? 21.000  8.380   22.711  1.000 11.933 0 45  ASN   C C     1 ? 
ATOM   363  O  O     . ASN   A 1 45  ? 21.420  8.125   23.857  1.000 15.071 0 45  ASN   C O     1 ? 
ATOM   364  C  CB    . ASN   A 1 45  ? 22.971  8.965   21.246  1.000 13.212 0 45  ASN   C CB    1 ? 
ATOM   365  C  CG    . ASN   A 1 45  ? 24.040  8.364   20.379  1.000 15.357 0 45  ASN   C CG    1 ? 
ATOM   366  O  OD1   . ASN   A 1 45  ? 24.794  7.495   20.824  1.000 16.870 0 45  ASN   C OD1   1 ? 
ATOM   367  N  ND2   . ASN   A 1 45  ? 24.048  8.677   19.096  1.000 14.485 0 45  ASN   C ND2   1 ? 
ATOM   368  N  N     . THR   A 1 46  ? 19.929  9.113   22.501  1.000 11.784 0 46  THR   C N     1 ? 
ATOM   369  C  CA    . THR   A 1 46  ? 19.039  9.488   23.596  1.000 11.710 0 46  THR   C CA    1 ? 
ATOM   370  C  C     . THR   A 1 46  ? 18.046  8.365   23.906  1.000 11.927 0 46  THR   C C     1 ? 
ATOM   371  O  O     . THR   A 1 46  ? 17.768  8.070   25.068  1.000 14.238 0 46  THR   C O     1 ? 
ATOM   372  C  CB    . THR   A 1 46  ? 18.357  10.838  23.348  1.000 12.907 0 46  THR   C CB    1 ? 
ATOM   373  O  OG1   . THR   A 1 46  ? 19.381  11.839  23.221  1.000 15.575 0 46  THR   C OG1   1 ? 
ATOM   374  C  CG2   . THR   A 1 46  ? 17.371  11.211  24.445  1.000 13.932 0 46  THR   C CG2   1 ? 
ATOM   375  N  N     . TYR   A 1 47  ? 17.373  7.846   22.889  1.000 10.516 0 47  TYR   C N     1 ? 
ATOM   376  C  CA    . TYR   A 1 47  ? 16.245  6.949   23.111  1.000 9.962  0 47  TYR   C CA    1 ? 
ATOM   377  C  C     . TYR   A 1 47  ? 16.524  5.460   22.891  1.000 9.989  0 47  TYR   C C     1 ? 
ATOM   378  O  O     . TYR   A 1 47  ? 15.643  4.659   23.181  1.000 11.817 0 47  TYR   C O     1 ? 
ATOM   379  C  CB    . TYR   A 1 47  ? 15.092  7.415   22.235  1.000 10.782 0 47  TYR   C CB    1 ? 
ATOM   380  C  CG    . TYR   A 1 47  ? 14.584  8.780   22.614  1.000 10.580 0 47  TYR   C CG    1 ? 
ATOM   381  C  CD1   . TYR   A 1 47  ? 13.833  8.944   23.769  1.000 11.923 0 47  TYR   C CD1   1 ? 
ATOM   382  C  CD2   . TYR   A 1 47  ? 14.881  9.946   21.912  1.000 11.092 0 47  TYR   C CD2   1 ? 
ATOM   383  C  CE1   . TYR   A 1 47  ? 13.385  10.197  24.148  1.000 11.440 0 47  TYR   C CE1   1 ? 
ATOM   384  C  CE2   . TYR   A 1 47  ? 14.427  11.211  22.272  1.000 11.719 0 47  TYR   C CE2   1 ? 
ATOM   385  C  CZ    . TYR   A 1 47  ? 13.687  11.337  23.434  1.000 11.688 0 47  TYR   C CZ    1 ? 
ATOM   386  O  OH    . TYR   A 1 47  ? 13.283  12.618  23.732  1.000 15.586 0 47  TYR   C OH    1 ? 
ATOM   387  N  N     . ASP   A 1 48  ? 17.637  5.133   22.232  1.000 10.010 0 48  ASP   C N     1 ? 
ATOM   388  C  CA    . ASP   A 1 48  ? 17.978  3.761   21.906  1.000 10.656 0 48  ASP   C CA    1 ? 
ATOM   389  C  C     . ASP   A 1 48  ? 16.891  3.084   21.093  1.000 10.676 0 48  ASP   C C     1 ? 
ATOM   390  O  O     . ASP   A 1 48  ? 16.584  1.921   21.355  1.000 10.184 0 48  ASP   C O     1 ? 
ATOM   391  C  CB    . ASP   A 1 48  ? 18.372  2.951   23.149  1.000 12.809 0 48  ASP   C CB    1 ? 
ATOM   392  C  CG    . ASP   A 1 48  ? 19.069  1.651   22.818  1.000 16.110 0 48  ASP   C CG    1 ? 
ATOM   393  O  OD1   . ASP   A 1 48  ? 19.720  1.509   21.741  1.000 15.495 0 48  ASP   C OD1   1 ? 
ATOM   394  O  OD2   . ASP   A 1 48  ? 18.982  0.751   23.709  1.000 20.350 0 48  ASP   C OD2   1 ? 
ATOM   395  N  N     . ASP   A 1 49  ? 16.360  3.750   20.058  1.000 9.427  0 49  ASP   C N     1 ? 
ATOM   396  C  CA    . ASP   A 1 49  ? 15.216  3.260   19.294  1.000 8.963  0 49  ASP   C CA    1 ? 
ATOM   397  C  C     . ASP   A 1 49  ? 15.641  2.787   17.907  1.000 9.263  0 49  ASP   C C     1 ? 
ATOM   398  O  O     . ASP   A 1 49  ? 14.775  2.582   17.043  1.000 9.087  0 49  ASP   C O     1 ? 
ATOM   399  C  CB    . ASP   A 1 49  ? 14.109  4.311   19.308  1.000 8.423  0 49  ASP   C CB    1 ? 
ATOM   400  C  CG    . ASP   A 1 49  ? 13.154  4.243   20.498  1.000 9.235  0 49  ASP   C CG    1 ? 
ATOM   401  O  OD1   . ASP   A 1 49  ? 13.082  3.131   21.097  1.000 11.369 0 49  ASP   C OD1   1 ? 
ATOM   402  O  OD2   . ASP   A 1 49  ? 12.575  5.309   20.826  1.000 10.456 0 49  ASP   C OD2   1 ? 
ATOM   403  N  N     . ILE   A 1 50  ? 16.942  2.521   17.659  1.000 8.852  0 50  ILE   C N     1 ? 
ATOM   404  C  CA    . ILE   A 1 50  ? 17.424  2.029   16.374  1.000 8.826  0 50  ILE   C CA    1 ? 
ATOM   405  C  C     . ILE   A 1 50  ? 18.211  0.705   16.473  1.000 8.953  0 50  ILE   C C     1 ? 
ATOM   406  O  O     . ILE   A 1 50  ? 17.915  -0.229  15.719  1.000 8.839  0 50  ILE   C O     1 ? 
ATOM   407  C  CB    . ILE   A 1 50  ? 18.251  3.053   15.583  1.000 8.814  0 50  ILE   C CB    1 ? 
ATOM   408  C  CG1   . ILE   A 1 50  ? 17.315  4.152   15.043  1.000 8.788  0 50  ILE   C CG1   1 ? 
ATOM   409  C  CG2   . ILE   A 1 50  ? 19.051  2.346   14.489  1.000 8.999  0 50  ILE   C CG2   1 ? 
ATOM   410  C  CD1   . ILE   A 1 50  ? 18.001  5.417   14.599  1.000 9.068  0 50  ILE   C CD1   1 ? 
ATOM   411  N  N     . GLU   A 1 51  ? 19.214  0.625   17.375  1.000 9.538  0 51  GLU   C N     1 ? 
ATOM   412  C  CA    . GLU   A 1 51  ? 20.118  -0.511  17.376  1.000 10.027 0 51  GLU   C CA    1 ? 
ATOM   413  C  C     . GLU   A 1 51  ? 19.345  -1.779  17.720  1.000 10.029 0 51  GLU   C C     1 ? 
ATOM   414  O  O     . GLU   A 1 51  ? 18.592  -1.837  18.705  1.000 11.141 0 51  GLU   C O     1 ? 
ATOM   415  C  CB    . GLU   A 1 51  ? 21.246  -0.207  18.354  1.000 12.136 0 51  GLU   C CB    1 ? 
ATOM   416  C  CG    . GLU   A 1 51  ? 22.349  -1.247  18.307  1.000 14.070 0 51  GLU   C CG    1 ? 
ATOM   417  C  CD    . GLU   A 1 51  ? 23.604  -0.971  19.108  1.000 18.633 0 51  GLU   C CD    1 ? 
ATOM   418  O  OE1   . GLU   A 1 51  ? 23.701  0.096   19.720  1.000 18.909 0 51  GLU   C OE1   1 ? 
ATOM   419  O  OE2   . GLU   A 1 51  ? 24.514  -1.802  19.023  1.000 23.027 0 51  GLU   C OE2   1 ? 
ATOM   420  N  N     . ASN   A 1 52  ? 19.531  -2.808  16.896  1.000 9.991  0 52  ASN   C N     1 ? 
ATOM   421  C  CA    . ASN   A 1 52  ? 18.926  -4.113  17.081  1.000 10.427 0 52  ASN   C CA    1 ? 
ATOM   422  C  C     . ASN   A 1 52  ? 17.405  -4.044  16.907  1.000 8.956  0 52  ASN   C C     1 ? 
ATOM   423  O  O     . ASN   A 1 52  ? 16.676  -4.959  17.314  1.000 9.284  0 52  ASN   C O     1 ? 
ATOM   424  C  CB    . ASN   A 1 52  ? 19.261  -4.768  18.436  1.000 11.638 0 52  ASN   C CB    1 ? 
ATOM   425  C  CG    . ASN   A 1 52  ? 20.740  -4.868  18.719  1.000 13.726 0 52  ASN   C CG    1 ? 
ATOM   426  O  OD1   . ASN   A 1 52  ? 21.540  -4.911  17.811  1.000 15.349 0 52  ASN   C OD1   1 ? 
ATOM   427  N  ND2   . ASN   A 1 52  ? 21.085  -4.716  19.985  1.000 17.384 0 52  ASN   C ND2   1 ? 
ATOM   428  N  N     . LYS   A 1 53  ? 16.905  -2.994  16.248  1.000 8.184  0 53  LYS   C N     1 ? 
ATOM   429  C  CA    . LYS   A 1 53  ? 15.473  -2.872  16.026  1.000 8.169  0 53  LYS   C CA    1 ? 
ATOM   430  C  C     . LYS   A 1 53  ? 15.129  -3.093  14.559  1.000 6.993  0 53  LYS   C C     1 ? 
ATOM   431  O  O     . LYS   A 1 53  ? 15.982  -3.030  13.685  1.000 7.816  0 53  LYS   C O     1 ? 
ATOM   432  C  CB    . LYS   A 1 53  ? 15.047  -1.435  16.362  1.000 9.551  0 53  LYS   C CB    1 ? 
ATOM   433  C  CG    . LYS   A 1 53  ? 15.446  -0.971  17.747  1.000 10.660 0 53  LYS   C CG    1 ? 
ATOM   434  C  CD    . LYS   A 1 53  ? 14.781  -1.754  18.848  1.000 13.028 0 53  LYS   C CD    1 ? 
ATOM   435  C  CE    . LYS   A 1 53  ? 15.123  -1.126  20.187  1.000 15.614 0 53  LYS   C CE    1 ? 
ATOM   436  N  NZ    . LYS   A 1 53  ? 14.559  -1.911  21.300  1.000 19.922 0 53  LYS   C NZ    1 ? 
ATOM   437  N  N     . VAL   A 1 54  ? 13.839  -3.332  14.293  1.000 7.329  0 54  VAL   C N     1 ? 
ATOM   438  C  CA    . VAL   A 1 54  ? 13.278  -3.272  12.962  1.000 7.408  0 54  VAL   C CA    1 ? 
ATOM   439  C  C     . VAL   A 1 54  ? 12.508  -1.954  12.847  1.000 7.075  0 54  VAL   C C     1 ? 
ATOM   440  O  O     . VAL   A 1 54  ? 11.642  -1.655  13.663  1.000 7.617  0 54  VAL   C O     1 ? 
ATOM   441  C  CB    . VAL   A 1 54  ? 12.480  -4.551  12.631  1.000 9.094  0 54  VAL   C CB    1 ? 
ATOM   442  C  CG1   . VAL   A 1 54  ? 11.319  -4.791  13.578  1.000 9.792  0 54  VAL   C CG1   1 ? 
ATOM   443  C  CG2   . VAL   A 1 54  ? 11.988  -4.578  11.201  1.000 9.708  0 54  VAL   C CG2   1 ? 
ATOM   444  N  N     . VAL   A 1 55  ? 12.904  -1.201  11.827  1.000 7.024  0 55  VAL   C N     1 ? 
ATOM   445  C  CA    . VAL   A 1 55  ? 12.524  0.189   11.677  1.000 6.607  0 55  VAL   C CA    1 ? 
ATOM   446  C  C     . VAL   A 1 55  ? 11.834  0.329   10.326  1.000 6.791  0 55  VAL   C C     1 ? 
ATOM   447  O  O     . VAL   A 1 55  ? 12.280  -0.285  9.332   1.000 7.698  0 55  VAL   C O     1 ? 
ATOM   448  C  CB    . VAL   A 1 55  ? 13.751  1.114   11.759  1.000 6.723  0 55  VAL   C CB    1 ? 
ATOM   449  C  CG1   . VAL   A 1 55  ? 13.353  2.574   11.631  1.000 6.081  0 55  VAL   C CG1   1 ? 
ATOM   450  C  CG2   . VAL   A 1 55  ? 14.518  0.883   13.025  1.000 7.042  0 55  VAL   C CG2   1 ? 
ATOM   451  N  N     . ALA   A 1 56  ? 10.800  1.172   10.259  1.000 6.070  0 56  ALA   C N     1 ? 
ATOM   452  C  CA    . ALA   A 1 56  ? 10.157  1.558   9.001   1.000 6.201  0 56  ALA   C CA    1 ? 
ATOM   453  C  C     . ALA   A 1 56  ? 10.416  3.037   8.755   1.000 6.366  0 56  ALA   C C     1 ? 
ATOM   454  O  O     . ALA   A 1 56  ? 10.273  3.824   9.676   1.000 7.528  0 56  ALA   C O     1 ? 
ATOM   455  C  CB    . ALA   A 1 56  ? 8.661   1.291   9.031   1.000 6.661  0 56  ALA   C CB    1 ? 
ATOM   456  N  N     . ASP   A 1 57  ? 10.731  3.380   7.507   1.000 6.701  0 57  ASP   C N     1 ? 
ATOM   457  C  CA    . ASP   A 1 57  ? 10.900  4.768   7.075   1.000 6.629  0 57  ASP   C CA    1 ? 
ATOM   458  C  C     . ASP   A 1 57  ? 9.803   5.043   6.055   1.000 7.242  0 57  ASP   C C     1 ? 
ATOM   459  O  O     . ASP   A 1 57  ? 9.801   4.495   4.943   1.000 7.363  0 57  ASP   C O     1 ? 
ATOM   460  C  CB    . ASP   A 1 57  ? 12.312  4.936   6.476   1.000 8.033  0 57  ASP   C CB    1 ? 
ATOM   461  C  CG    . ASP   A 1 57  ? 12.592  6.304   5.888   1.000 8.518  0 57  ASP   C CG    1 ? 
ATOM   462  O  OD1   . ASP   A 1 57  ? 11.756  7.219   5.973   1.000 9.626  0 57  ASP   C OD1   1 ? 
ATOM   463  O  OD2   . ASP   A 1 57  ? 13.699  6.411   5.266   1.000 9.127  0 57  ASP   C OD2   1 ? 
ATOM   464  N  N     . LEU   A 1 58  ? 8.792   5.819   6.445   1.000 6.983  0 58  LEU   C N     1 ? 
ATOM   465  C  CA    . LEU   A 1 58  ? 7.635   6.115   5.579   1.000 7.114  0 58  LEU   C CA    1 ? 
ATOM   466  C  C     . LEU   A 1 58  ? 7.926   7.351   4.731   1.000 7.100  0 58  LEU   C C     1 ? 
ATOM   467  O  O     . LEU   A 1 58  ? 8.357   8.391   5.203   1.000 7.965  0 58  LEU   C O     1 ? 
ATOM   468  C  CB    . LEU   A 1 58  ? 6.381   6.370   6.430   1.000 7.786  0 58  LEU   C CB    1 ? 
ATOM   469  C  CG    . LEU   A 1 58  ? 5.997   5.221   7.358   1.000 7.996  0 58  LEU   C CG    1 ? 
ATOM   470  C  CD1   . LEU   A 1 58  ? 4.704   5.565   8.117   1.000 8.057  0 58  LEU   C CD1   1 ? 
ATOM   471  C  CD2   . LEU   A 1 58  ? 5.928   3.874   6.664   1.000 8.273  0 58  LEU   C CD2   1 ? 
ATOM   472  N  N     . GLY   A 1 59  ? 7.658   7.222   3.423   1.000 6.721  0 59  GLY   C N     1 ? 
ATOM   473  C  CA    . GLY   A 1 59  ? 8.095   8.211   2.443   1.000 7.172  0 59  GLY   C CA    1 ? 
ATOM   474  C  C     . GLY   A 1 59  ? 9.605   8.279   2.360   1.000 7.293  0 59  GLY   C C     1 ? 
ATOM   475  O  O     . GLY   A 1 59  ? 10.186  9.328   2.465   1.000 7.596  0 59  GLY   C O     1 ? 
ATOM   476  N  N     . CYS   A 1 60  ? 10.241  7.140   2.212   1.000 6.948  0 60  CYS   C N     1 ? 
ATOM   477  C  CA    . CYS   A 1 60  ? 11.687  7.013   2.334   1.000 7.211  0 60  CYS   C CA    1 ? 
ATOM   478  C  C     . CYS   A 1 60  ? 12.461  7.722   1.213   1.000 6.895  0 60  CYS   C C     1 ? 
ATOM   479  O  O     . CYS   A 1 60  ? 13.626  7.986   1.404   1.000 7.120  0 60  CYS   C O     1 ? 
ATOM   480  C  CB    . CYS   A 1 60  ? 12.090  5.536   2.390   1.000 7.334  0 60  CYS   C CB    1 ? 
ATOM   481  S  SG    . CYS   A 1 60  ? 11.686  4.588   0.890   1.000 7.866  0 60  CYS   C SG    1 ? 
ATOM   482  N  N     . GLY   A 1 61  ? 11.853  8.012   0.081   1.000 7.039  0 61  GLY   C N     1 ? 
ATOM   483  C  CA    . GLY   A 1 61  ? 12.527  8.747   -0.962  1.000 7.464  0 61  GLY   C CA    1 ? 
ATOM   484  C  C     . GLY   A 1 61  ? 13.789  8.062   -1.456  1.000 7.601  0 61  GLY   C C     1 ? 
ATOM   485  O  O     . GLY   A 1 61  ? 13.857  6.849   -1.669  1.000 7.921  0 61  GLY   C O     1 ? 
ATOM   486  N  N     . CYS   A 1 62  ? 14.786  8.901   -1.569  1.000 7.410  0 62  CYS   C N     1 ? 
ATOM   487  C  CA    . CYS   A 1 62  ? 16.101  8.449   -2.001  1.000 8.219  0 62  CYS   C CA    1 ? 
ATOM   488  C  C     . CYS   A 1 62  ? 16.892  7.767   -0.891  1.000 7.730  0 62  CYS   C C     1 ? 
ATOM   489  O  O     . CYS   A 1 62  ? 17.964  7.253   -1.147  1.000 8.482  0 62  CYS   C O     1 ? 
ATOM   490  C  CB    . CYS   A 1 62  ? 16.956  9.636   -2.497  1.000 9.042  0 62  CYS   C CB    1 ? 
ATOM   491  S  SG    . CYS   A 1 62  ? 17.490  10.900  -1.275  1.000 12.428 0 62  CYS   C SG    1 ? 
ATOM   492  N  N     . GLY   A 1 63  ? 16.362  7.805   0.330   1.000 7.710  0 63  GLY   C N     1 ? 
ATOM   493  C  CA    . GLY   A 1 63  ? 16.827  6.953   1.412   1.000 8.422  0 63  GLY   C CA    1 ? 
ATOM   494  C  C     . GLY   A 1 63  ? 17.674  7.559   2.508   1.000 7.919  0 63  GLY   C C     1 ? 
ATOM   495  O  O     . GLY   A 1 63  ? 18.194  6.838   3.340   1.000 9.471  0 63  GLY   C O     1 ? 
ATOM   496  N  N     . VAL   A 1 64  ? 17.773  8.883   2.600   1.000 7.135  0 64  VAL   C N     1 ? 
ATOM   497  C  CA    . VAL   A 1 64  ? 18.679  9.454   3.585   1.000 7.543  0 64  VAL   C CA    1 ? 
ATOM   498  C  C     . VAL   A 1 64  ? 18.441  8.905   4.980   1.000 7.411  0 64  VAL   C C     1 ? 
ATOM   499  O  O     . VAL   A 1 64  ? 19.390  8.555   5.677   1.000 8.230  0 64  VAL   C O     1 ? 
ATOM   500  C  CB    . VAL   A 1 64  ? 18.573  10.996  3.596   1.000 8.389  0 64  VAL   C CB    1 ? 
ATOM   501  C  CG1   . VAL   A 1 64  ? 19.421  11.572  4.713   1.000 9.856  0 64  VAL   C CG1   1 ? 
ATOM   502  C  CG2   . VAL   A 1 64  ? 18.984  11.626  2.248   1.000 9.377  0 64  VAL   C CG2   1 ? 
ATOM   503  N  N     . LEU   A 1 65  ? 17.193  8.900   5.458   1.000 7.124  0 65  LEU   C N     1 ? 
ATOM   504  C  CA    . LEU   A 1 65  ? 16.914  8.486   6.836   1.000 6.881  0 65  LEU   C CA    1 ? 
ATOM   505  C  C     . LEU   A 1 65  ? 17.178  6.991   7.010   1.000 6.960  0 65  LEU   C C     1 ? 
ATOM   506  O  O     . LEU   A 1 65  ? 17.593  6.600   8.071   1.000 7.554  0 65  LEU   C O     1 ? 
ATOM   507  C  CB    . LEU   A 1 65  ? 15.491  8.842   7.248   1.000 7.439  0 65  LEU   C CB    1 ? 
ATOM   508  C  CG    . LEU   A 1 65  ? 15.243  10.315  7.483   1.000 8.180  0 65  LEU   C CG    1 ? 
ATOM   509  C  CD1   . LEU   A 1 65  ? 13.777  10.583  7.719   1.000 9.532  0 65  LEU   C CD1   1 ? 
ATOM   510  C  CD2   . LEU   A 1 65  ? 16.019  10.814  8.694   1.000 8.202  0 65  LEU   C CD2   1 ? 
ATOM   511  N  N     . SER   A 1 66  ? 16.862  6.195   6.003   1.000 6.826  0 66  SER   C N     1 ? 
ATOM   512  C  CA    . SER   A 1 66  ? 17.062  4.760   6.095   1.000 7.183  0 66  SER   C CA    1 ? 
ATOM   513  C  C     . SER   A 1 66  ? 18.550  4.407   6.082   1.000 7.812  0 66  SER   C C     1 ? 
ATOM   514  O  O     . SER   A 1 66  ? 18.964  3.464   6.741   1.000 7.208  0 66  SER   C O     1 ? 
ATOM   515  C  CB    . SER   A 1 66  ? 16.361  4.052   4.959   1.000 8.265  0 66  SER   C CB    1 ? 
ATOM   516  O  OG    . SER   A 1 66  ? 14.941  3.987   5.118   1.000 8.358  0 66  SER   C OG    1 ? 
ATOM   517  N  N     . ILE   A 1 67  ? 19.312  5.050   5.188   1.000 7.576  0 67  ILE   C N     1 ? 
ATOM   518  C  CA    . ILE   A 1 67  ? 20.741  4.851   5.114   1.000 8.016  0 67  ILE   C CA    1 ? 
ATOM   519  C  C     . ILE   A 1 67  ? 21.378  5.129   6.473   1.000 8.229  0 67  ILE   C C     1 ? 
ATOM   520  O  O     . ILE   A 1 67  ? 22.195  4.349   6.970   1.000 8.630  0 67  ILE   C O     1 ? 
ATOM   521  C  CB    . ILE   A 1 67  ? 21.359  5.714   3.979   1.000 9.327  0 67  ILE   C CB    1 ? 
ATOM   522  C  CG1   . ILE   A 1 67  ? 20.892  5.303   2.581   1.000 13.718 0 67  ILE   C CG1   1 ? 
ATOM   523  C  CG2   . ILE   A 1 67  ? 22.861  5.744   4.089   1.000 9.505  0 67  ILE   C CG2   1 ? 
ATOM   524  C  CD1   . ILE   A 1 67  ? 21.405  4.005   2.162   1.000 15.013 0 67  ILE   C CD1   1 ? 
ATOM   525  N  N     . GLY   A 1 68  ? 21.017  6.273   7.068   1.000 6.871  0 68  GLY   C N     1 ? 
ATOM   526  C  CA    . GLY   A 1 68  ? 21.566  6.555   8.385   1.000 7.564  0 68  GLY   C CA    1 ? 
ATOM   527  C  C     . GLY   A 1 68  ? 21.154  5.533   9.450   1.000 8.382  0 68  GLY   C C     1 ? 
ATOM   528  O  O     . GLY   A 1 68  ? 21.984  5.124   10.263  1.000 8.447  0 68  GLY   C O     1 ? 
ATOM   529  N  N     . THR   A 1 69  ? 19.880  5.142   9.436   1.000 8.119  0 69  THR   C N     1 ? 
ATOM   530  C  CA    . THR   A 1 69  ? 19.385  4.161   10.401  1.000 7.984  0 69  THR   C CA    1 ? 
ATOM   531  C  C     . THR   A 1 69  ? 20.161  2.862   10.288  1.000 7.583  0 69  THR   C C     1 ? 
ATOM   532  O  O     . THR   A 1 69  ? 20.568  2.268   11.272  1.000 8.631  0 69  THR   C O     1 ? 
ATOM   533  C  CB    . THR   A 1 69  ? 17.891  3.927   10.154  1.000 8.414  0 69  THR   C CB    1 ? 
ATOM   534  O  OG1   . THR   A 1 69  ? 17.168  5.136   10.417  1.000 8.074  0 69  THR   C OG1   1 ? 
ATOM   535  C  CG2   . THR   A 1 69  ? 17.288  2.840   10.982  1.000 8.199  0 69  THR   C CG2   1 ? 
ATOM   536  N  N     . ALA   A 1 70  ? 20.401  2.404   9.058   1.000 7.194  0 70  ALA   C N     1 ? 
ATOM   537  C  CA    . ALA   A 1 70  ? 21.111  1.148   8.808   1.000 7.425  0 70  ALA   C CA    1 ? 
ATOM   538  C  C     . ALA   A 1 70  ? 22.566  1.227   9.301   1.000 8.851  0 70  ALA   C C     1 ? 
ATOM   539  O  O     . ALA   A 1 70  ? 23.101  0.241   9.774   1.000 10.166 0 70  ALA   C O     1 ? 
ATOM   540  C  CB    . ALA   A 1 70  ? 21.058  0.898   7.326   1.000 7.709  0 70  ALA   C CB    1 ? 
ATOM   541  N  N     . MET   A 1 71  ? 23.181  2.413   9.291   1.000 9.151  0 71  MET   C N     1 ? 
ATOM   542  C  CA    . MET   A 1 71  ? 24.557  2.553   9.785   1.000 10.705 0 71  MET   C CA    1 ? 
ATOM   543  C  C     . MET   A 1 71  ? 24.634  2.643   11.294  1.000 11.196 0 71  MET   C C     1 ? 
ATOM   544  O  O     . MET   A 1 71  ? 25.737  2.618   11.837  1.000 12.848 0 71  MET   C O     1 ? 
ATOM   545  C  CB    . MET   A 1 71  ? 25.226  3.785   9.178   1.000 11.157 0 71  MET   C CB    1 ? 
ATOM   546  C  CG    . MET   A 1 71  ? 25.513  3.593   7.724   1.000 11.851 0 71  MET   C CG    1 ? 
ATOM   547  S  SD    . MET   A 1 71  ? 26.437  4.895   6.905   1.000 16.702 0 71  MET   C SD    1 ? 
ATOM   548  C  CE    . MET   A 1 71  ? 25.345  6.275   7.163   1.000 15.662 0 71  MET   C CE    1 ? 
ATOM   549  N  N     . LEU   A 1 72  ? 23.517  2.835   11.975  1.000 9.941  0 72  LEU   C N     1 ? 
ATOM   550  C  CA    . LEU   A 1 72  ? 23.467  2.954   13.431  1.000 10.298 0 72  LEU   C CA    1 ? 
ATOM   551  C  C     . LEU   A 1 72  ? 23.042  1.652   14.079  1.000 11.107 0 72  LEU   C C     1 ? 
ATOM   552  O  O     . LEU   A 1 72  ? 22.694  1.684   15.262  1.000 12.759 0 72  LEU   C O     1 ? 
ATOM   553  C  CB    . LEU   A 1 72  ? 22.568  4.121   13.857  1.000 10.736 0 72  LEU   C CB    1 ? 
ATOM   554  C  CG    . LEU   A 1 72  ? 23.091  5.520   13.493  1.000 10.583 0 72  LEU   C CG    1 ? 
ATOM   555  C  CD1   . LEU   A 1 72  ? 22.068  6.596   13.726  1.000 11.893 0 72  LEU   C CD1   1 ? 
ATOM   556  C  CD2   . LEU   A 1 72  ? 24.404  5.868   14.206  1.000 10.974 0 72  LEU   C CD2   1 ? 
ATOM   557  N  N     . GLY   A 1 73  ? 23.094  0.534   13.364  1.000 11.279 0 73  GLY   C N     1 ? 
ATOM   558  C  CA    . GLY   A 1 73  ? 22.938  -0.738  14.007  1.000 12.197 0 73  GLY   C CA    1 ? 
ATOM   559  C  C     . GLY   A 1 73  ? 21.551  -1.373  13.896  1.000 10.328 0 73  GLY   C C     1 ? 
ATOM   560  O  O     . GLY   A 1 73  ? 21.308  -2.336  14.608  1.000 10.115 0 73  GLY   C O     1 ? 
ATOM   561  N  N     . ALA   A 1 74  ? 20.620  -0.809  13.102  1.000 9.244  0 74  ALA   C N     1 ? 
ATOM   562  C  CA    . ALA   A 1 74  ? 19.308  -1.434  12.953  1.000 8.303  0 74  ALA   C CA    1 ? 
ATOM   563  C  C     . ALA   A 1 74  ? 19.500  -2.883  12.523  1.000 7.874  0 74  ALA   C C     1 ? 
ATOM   564  O  O     . ALA   A 1 74  ? 20.378  -3.189  11.723  1.000 8.901  0 74  ALA   C O     1 ? 
ATOM   565  C  CB    . ALA   A 1 74  ? 18.438  -0.695  11.937  1.000 8.405  0 74  ALA   C CB    1 ? 
ATOM   566  N  N     . GLY   A 1 75  ? 18.636  -3.789  12.968  1.000 7.668  0 75  GLY   C N     1 ? 
ATOM   567  C  CA    . GLY   A 1 75  ? 18.603  -5.142  12.431  1.000 7.983  0 75  GLY   C CA    1 ? 
ATOM   568  C  C     . GLY   A 1 75  ? 18.089  -5.138  11.006  1.000 7.597  0 75  GLY   C C     1 ? 
ATOM   569  O  O     . GLY   A 1 75  ? 18.637  -5.789  10.168  1.000 9.229  0 75  GLY   C O     1 ? 
ATOM   570  N  N     . LEU   A 1 76  ? 17.067  -4.288  10.732  1.000 6.933  0 76  LEU   C N     1 ? 
ATOM   571  C  CA    . LEU   A 1 76  ? 16.521  -4.146  9.387   1.000 7.342  0 76  LEU   C CA    1 ? 
ATOM   572  C  C     . LEU   A 1 76  ? 15.780  -2.819  9.334   1.000 7.544  0 76  LEU   C C     1 ? 
ATOM   573  O  O     . LEU   A 1 76  ? 14.999  -2.539  10.234  1.000 7.971  0 76  LEU   C O     1 ? 
ATOM   574  C  CB    . LEU   A 1 76  ? 15.549  -5.280  9.079   1.000 7.706  0 76  LEU   C CB    1 ? 
ATOM   575  C  CG    . LEU   A 1 76  ? 14.905  -5.215  7.691   1.000 7.963  0 76  LEU   C CG    1 ? 
ATOM   576  C  CD1   . LEU   A 1 76  ? 15.896  -5.370  6.564   1.000 8.760  0 76  LEU   C CD1   1 ? 
ATOM   577  C  CD2   . LEU   A 1 76  ? 13.827  -6.314  7.565   1.000 8.897  0 76  LEU   C CD2   1 ? 
ATOM   578  N  N     . CYS   A 1 77  ? 16.063  -2.004  8.313   1.000 7.673  0 77  CYS   C N     1 ? 
ATOM   579  C  CA    . CYS   A 1 77  ? 15.253  -0.849  8.031   1.000 6.957  0 77  CYS   C CA    1 ? 
ATOM   580  C  C     . CYS   A 1 77  ? 14.520  -1.061  6.715   1.000 6.129  0 77  CYS   C C     1 ? 
ATOM   581  O  O     . CYS   A 1 77  ? 15.169  -1.293  5.686   1.000 7.809  0 77  CYS   C O     1 ? 
ATOM   582  C  CB    . CYS   A 1 77  ? 16.116  0.401   7.997   1.000 7.740  0 77  CYS   C CB    1 ? 
ATOM   583  S  SG    . CYS   A 1 77  ? 15.202  1.962   7.906   1.000 10.136 0 77  CYS   C SG    1 ? 
ATOM   584  N  N     . VAL   A 1 78  ? 13.197  -0.925  6.728   1.000 6.297  0 78  VAL   C N     1 ? 
ATOM   585  C  CA    . VAL   A 1 78  ? 12.385  -1.049  5.541   1.000 6.162  0 78  VAL   C CA    1 ? 
ATOM   586  C  C     . VAL   A 1 78  ? 11.851  0.327   5.171   1.000 6.925  0 78  VAL   C C     1 ? 
ATOM   587  O  O     . VAL   A 1 78  ? 11.135  0.939   5.961   1.000 7.248  0 78  VAL   C O     1 ? 
ATOM   588  C  CB    . VAL   A 1 78  ? 11.237  -2.080  5.725   1.000 6.945  0 78  VAL   C CB    1 ? 
ATOM   589  C  CG1   . VAL   A 1 78  ? 10.542  -2.268  4.391   1.000 6.591  0 78  VAL   C CG1   1 ? 
ATOM   590  C  CG2   . VAL   A 1 78  ? 11.757  -3.404  6.298   1.000 7.308  0 78  VAL   C CG2   1 ? 
ATOM   591  N  N     . GLY   A 1 79  ? 12.186  0.784   3.963   1.000 7.089  0 79  GLY   C N     1 ? 
ATOM   592  C  CA    . GLY   A 1 79  ? 11.660  2.037   3.452   1.000 7.036  0 79  GLY   C CA    1 ? 
ATOM   593  C  C     . GLY   A 1 79  ? 10.416  1.808   2.599   1.000 7.595  0 79  GLY   C C     1 ? 
ATOM   594  O  O     . GLY   A 1 79  ? 10.383  0.841   1.814   1.000 8.774  0 79  GLY   C O     1 ? 
ATOM   595  N  N     . PHE   A 1 80  ? 9.460   2.703   2.685   1.000 6.417  0 80  PHE   C N     1 ? 
ATOM   596  C  CA    . PHE   A 1 80  ? 8.221   2.622   1.938   1.000 6.555  0 80  PHE   C CA    1 ? 
ATOM   597  C  C     . PHE   A 1 80  ? 8.051   3.944   1.180   1.000 6.450  0 80  PHE   C C     1 ? 
ATOM   598  O  O     . PHE   A 1 80  ? 8.173   5.033   1.758   1.000 7.302  0 80  PHE   C O     1 ? 
ATOM   599  C  CB    . PHE   A 1 80  ? 7.043   2.436   2.900   1.000 7.101  0 80  PHE   C CB    1 ? 
ATOM   600  C  CG    . PHE   A 1 80  ? 7.051   1.172   3.718   1.000 7.281  0 80  PHE   C CG    1 ? 
ATOM   601  C  CD1   . PHE   A 1 80  ? 7.792   1.084   4.898   1.000 6.679  0 80  PHE   C CD1   1 ? 
ATOM   602  C  CD2   . PHE   A 1 80  ? 6.371   0.029   3.300   1.000 8.444  0 80  PHE   C CD2   1 ? 
ATOM   603  C  CE1   . PHE   A 1 80  ? 7.846   -0.140  5.576   1.000 6.965  0 80  PHE   C CE1   1 ? 
ATOM   604  C  CE2   . PHE   A 1 80  ? 6.392   -1.157  4.019   1.000 8.263  0 80  PHE   C CE2   1 ? 
ATOM   605  C  CZ    . PHE   A 1 80  ? 7.133   -1.239  5.170   1.000 8.072  0 80  PHE   C CZ    1 ? 
ATOM   606  N  N     . ASP   A 1 81  ? 7.744   3.870   -0.128  1.000 6.538  0 81  ASP   C N     1 ? 
ATOM   607  C  CA    . ASP   A 1 81  ? 7.512   5.102   -0.900  1.000 6.866  0 81  ASP   C CA    1 ? 
ATOM   608  C  C     . ASP   A 1 81  ? 6.552   4.737   -2.035  1.000 7.111  0 81  ASP   C C     1 ? 
ATOM   609  O  O     . ASP   A 1 81  ? 6.550   3.612   -2.519  1.000 8.059  0 81  ASP   C O     1 ? 
ATOM   610  C  CB    . ASP   A 1 81  ? 8.794   5.694   -1.505  1.000 7.346  0 81  ASP   C CB    1 ? 
ATOM   611  C  CG    . ASP   A 1 81  ? 8.712   7.186   -1.792  1.000 7.723  0 81  ASP   C CG    1 ? 
ATOM   612  O  OD1   . ASP   A 1 81  ? 8.065   7.529   -2.809  1.000 8.397  0 81  ASP   C OD1   1 ? 
ATOM   613  O  OD2   . ASP   A 1 81  ? 9.208   7.983   -0.974  1.000 8.202  0 81  ASP   C OD2   1 ? 
ATOM   614  N  N     . ILE   A 1 82  ? 5.739   5.685   -2.490  1.000 7.129  0 82  ILE   C N     1 ? 
ATOM   615  C  CA    . ILE   A 1 82  ? 4.820   5.472   -3.591  1.000 7.492  0 82  ILE   C CA    1 ? 
ATOM   616  C  C     . ILE   A 1 82  ? 5.513   5.458   -4.953  1.000 7.489  0 82  ILE   C C     1 ? 
ATOM   617  O  O     . ILE   A 1 82  ? 4.888   4.986   -5.918  1.000 8.702  0 82  ILE   C O     1 ? 
ATOM   618  C  CB    . ILE   A 1 82  ? 3.710   6.532   -3.498  1.000 7.910  0 82  ILE   C CB    1 ? 
ATOM   619  C  CG1   . ILE   A 1 82  ? 2.438   6.091   -4.220  1.000 8.883  0 82  ILE   C CG1   1 ? 
ATOM   620  C  CG2   . ILE   A 1 82  ? 4.200   7.899   -3.949  1.000 8.787  0 82  ILE   C CG2   1 ? 
ATOM   621  C  CD1   . ILE   A 1 82  ? 1.233   6.949   -3.937  1.000 9.859  0 82  ILE   C CD1   1 ? 
ATOM   622  N  N     . ASP   A 1 83  ? 6.718   6.041   -5.067  1.000 8.091  0 83  ASP   C N     1 ? 
ATOM   623  C  CA    . ASP   A 1 83  ? 7.351   6.279   -6.361  1.000 8.329  0 83  ASP   C CA    1 ? 
ATOM   624  C  C     . ASP   A 1 83  ? 8.505   5.326   -6.622  1.000 9.229  0 83  ASP   C C     1 ? 
ATOM   625  O  O     . ASP   A 1 83  ? 9.519   5.288   -5.941  1.000 8.694  0 83  ASP   C O     1 ? 
ATOM   626  C  CB    . ASP   A 1 83  ? 7.902   7.705   -6.375  1.000 9.181  0 83  ASP   C CB    1 ? 
ATOM   627  C  CG    . ASP   A 1 83  ? 8.581   8.068   -7.671  1.000 12.081 0 83  ASP   C CG    1 ? 
ATOM   628  O  OD1   . ASP   A 1 83  ? 8.241   7.490   -8.710  1.000 15.983 0 83  ASP   C OD1   1 ? 
ATOM   629  O  OD2   . ASP   A 1 83  ? 9.483   8.910   -7.646  1.000 14.201 0 83  ASP   C OD2   1 ? 
ATOM   630  N  N     . GLU   A 1 84  ? 8.355   4.578   -7.708  1.000 9.991  0 84  GLU   C N     1 ? 
ATOM   631  C  CA    . GLU   A 1 84  ? 9.366   3.618   -8.132  1.000 10.334 0 84  GLU   C CA    1 ? 
ATOM   632  C  C     . GLU   A 1 84  ? 10.691  4.307   -8.491  1.000 9.212  0 84  GLU   C C     1 ? 
ATOM   633  O  O     . GLU   A 1 84  ? 11.738  3.734   -8.252  1.000 10.452 0 84  GLU   C O     1 ? 
ATOM   634  C  CB    . GLU   A 1 84  ? 8.904   2.760   -9.318  1.000 13.229 0 84  GLU   C CB    1 ? 
ATOM   635  C  CG    . GLU   A 1 84  ? 8.638   3.475   -10.627 1.000 16.790 0 84  GLU   C CG    1 ? 
ATOM   636  C  CD    . GLU   A 1 84  ? 7.280   4.150   -10.796 1.000 20.376 0 84  GLU   C CD    1 ? 
ATOM   637  O  OE1   . GLU   A 1 84  ? 6.537   4.284   -9.808  1.000 19.009 0 84  GLU   C OE1   1 ? 
ATOM   638  O  OE2   . GLU   A 1 84  ? 6.940   4.550   -11.963 1.000 23.790 0 84  GLU   C OE2   1 ? 
ATOM   639  N  N     . ASP   A 1 85  ? 10.642  5.509   -9.018  1.000 10.051 0 85  ASP   C N     1 ? 
ATOM   640  C  CA    . ASP   A 1 85  ? 11.885  6.164   -9.422  1.000 10.580 0 85  ASP   C CA    1 ? 
ATOM   641  C  C     . ASP   A 1 85  ? 12.721  6.526   -8.193  1.000 11.384 0 85  ASP   C C     1 ? 
ATOM   642  O  O     . ASP   A 1 85  ? 13.944  6.368   -8.201  1.000 12.083 0 85  ASP   C O     1 ? 
ATOM   643  C  CB    . ASP   A 1 85  ? 11.644  7.388   -10.291 1.000 12.576 0 85  ASP   C CB    1 ? 
ATOM   644  C  CG    . ASP   A 1 85  ? 10.992  7.141   -11.649 1.000 13.665 0 85  ASP   C CG    1 ? 
ATOM   645  O  OD1   . ASP   A 1 85  ? 11.033  5.990   -12.094 1.000 15.427 0 85  ASP   C OD1   1 ? 
ATOM   646  O  OD2   . ASP   A 1 85  ? 10.308  8.065   -12.164 1.000 18.301 0 85  ASP   C OD2   1 ? 
ATOM   647  N  N     . ALA   A 1 86  ? 12.068  6.910   -7.101  1.000 10.126 0 86  ALA   C N     1 ? 
ATOM   648  C  CA    . ALA   A 1 86  ? 12.756  7.218   -5.847  1.000 9.467  0 86  ALA   C CA    1 ? 
ATOM   649  C  C     . ALA   A 1 86  ? 13.422  5.975   -5.289  1.000 9.821  0 86  ALA   C C     1 ? 
ATOM   650  O  O     . ALA   A 1 86  ? 14.579  5.967   -4.874  1.000 9.880  0 86  ALA   C O     1 ? 
ATOM   651  C  CB    . ALA   A 1 86  ? 11.778  7.852   -4.875  1.000 10.396 0 86  ALA   C CB    1 ? 
ATOM   652  N  N     . LEU   A 1 87  ? 12.658  4.885   -5.311  1.000 8.796  0 87  LEU   C N     1 ? 
ATOM   653  C  CA    . LEU   A 1 87  ? 13.151  3.621   -4.798  1.000 8.732  0 87  LEU   C CA    1 ? 
ATOM   654  C  C     . LEU   A 1 87  ? 14.328  3.034   -5.583  1.000 9.194  0 87  LEU   C C     1 ? 
ATOM   655  O  O     . LEU   A 1 87  ? 15.218  2.451   -4.990  1.000 9.752  0 87  LEU   C O     1 ? 
ATOM   656  C  CB    . LEU   A 1 87  ? 12.003  2.599   -4.694  1.000 8.862  0 87  LEU   C CB    1 ? 
ATOM   657  C  CG    . LEU   A 1 87  ? 10.903  2.966   -3.703  1.000 8.787  0 87  LEU   C CG    1 ? 
ATOM   658  C  CD1   . LEU   A 1 87  ? 9.789   1.941   -3.713  1.000 9.864  0 87  LEU   C CD1   1 ? 
ATOM   659  C  CD2   . LEU   A 1 87  ? 11.448  3.163   -2.289  1.000 9.464  0 87  LEU   C CD2   1 ? 
ATOM   660  N  N     . GLU   A 1 88  ? 14.360  3.276   -6.901  1.000 10.025 0 88  GLU   C N     1 ? 
ATOM   661  C  CA    . GLU   A 1 88  ? 15.510  2.870   -7.699  1.000 11.347 0 88  GLU   C CA    1 ? 
ATOM   662  C  C     . GLU   A 1 88  ? 16.779  3.561   -7.229  1.000 10.028 0 88  GLU   C C     1 ? 
ATOM   663  O  O     . GLU   A 1 88  ? 17.832  2.934   -7.099  1.000 11.450 0 88  GLU   C O     1 ? 
ATOM   664  C  CB    . GLU   A 1 88  ? 15.210  3.233   -9.152  1.000 14.497 0 88  GLU   C CB    1 ? 
ATOM   665  C  CG    . GLU   A 1 88  ? 16.289  2.838   -10.166 1.000 19.190 0 88  GLU   C CG    1 ? 
ATOM   666  C  CD    . GLU   A 1 88  ? 16.108  3.300   -11.612 1.000 28.027 0 88  GLU   C CD    1 ? 
ATOM   667  O  OE1   . GLU   A 1 88  ? 15.130  4.049   -11.913 1.000 28.203 0 88  GLU   C OE1   1 ? 
ATOM   668  O  OE2   . GLU   A 1 88  ? 16.975  2.907   -12.457 1.000 35.090 0 88  GLU   C OE2   1 ? 
ATOM   669  N  N     . ILE   A 1 89  ? 16.665  4.874   -6.967  1.000 9.725  0 89  ILE   C N     1 ? 
ATOM   670  C  CA    . ILE   A 1 89  ? 17.780  5.640   -6.433  1.000 9.581  0 89  ILE   C CA    1 ? 
ATOM   671  C  C     . ILE   A 1 89  ? 18.202  5.166   -5.045  1.000 9.527  0 89  ILE   C C     1 ? 
ATOM   672  O  O     . ILE   A 1 89  ? 19.384  5.031   -4.712  1.000 9.738  0 89  ILE   C O     1 ? 
ATOM   673  C  CB    . ILE   A 1 89  ? 17.453  7.146   -6.465  1.000 11.162 0 89  ILE   C CB    1 ? 
ATOM   674  C  CG1   . ILE   A 1 89  ? 17.286  7.563   -7.932  1.000 12.982 0 89  ILE   C CG1   1 ? 
ATOM   675  C  CG2   . ILE   A 1 89  ? 18.520  7.938   -5.732  1.000 13.047 0 89  ILE   C CG2   1 ? 
ATOM   676  C  CD1   . ILE   A 1 89  ? 16.713  8.922   -8.173  1.000 14.894 0 89  ILE   C CD1   1 ? 
ATOM   677  N  N     . PHE   A 1 90  ? 17.215  4.899   -4.206  1.000 9.545  0 90  PHE   C N     1 ? 
ATOM   678  C  CA    . PHE   A 1 90  ? 17.499  4.409   -2.870  1.000 9.543  0 90  PHE   C CA    1 ? 
ATOM   679  C  C     . PHE   A 1 90  ? 18.261  3.090   -2.942  1.000 10.030 0 90  PHE   C C     1 ? 
ATOM   680  O  O     . PHE   A 1 90  ? 19.266  2.907   -2.246  1.000 9.473  0 90  PHE   C O     1 ? 
ATOM   681  C  CB    . PHE   A 1 90  ? 16.163  4.259   -2.138  1.000 7.995  0 90  PHE   C CB    1 ? 
ATOM   682  C  CG    . PHE   A 1 90  ? 16.204  3.760   -0.720  1.000 8.783  0 90  PHE   C CG    1 ? 
ATOM   683  C  CD1   . PHE   A 1 90  ? 17.369  3.622   0.029   1.000 8.890  0 90  PHE   C CD1   1 ? 
ATOM   684  C  CD2   . PHE   A 1 90  ? 15.014  3.304   -0.135  1.000 9.096  0 90  PHE   C CD2   1 ? 
ATOM   685  C  CE1   . PHE   A 1 90  ? 17.326  3.198   1.347   1.000 9.005  0 90  PHE   C CE1   1 ? 
ATOM   686  C  CE2   . PHE   A 1 90  ? 14.991  2.827   1.177   1.000 9.349  0 90  PHE   C CE2   1 ? 
ATOM   687  C  CZ    . PHE   A 1 90  ? 16.165  2.703   1.888   1.000 9.281  0 90  PHE   C CZ    1 ? 
ATOM   688  N  N     . ASN   A 1 91  ? 17.772  2.166   -3.767  1.000 10.257 0 91  ASN   C N     1 ? 
ATOM   689  C  CA    . ASN   A 1 91  ? 18.509  0.923   -3.942  1.000 12.402 0 91  ASN   C CA    1 ? 
ATOM   690  C  C     . ASN   A 1 91  ? 19.963  1.131   -4.372  1.000 12.426 0 91  ASN   C C     1 ? 
ATOM   691  O  O     . ASN   A 1 91  ? 20.893  0.524   -3.804  1.000 12.318 0 91  ASN   C O     1 ? 
ATOM   692  C  CB    . ASN   A 1 91  ? 17.835  0.046   -4.980  1.000 15.231 0 91  ASN   C CB    1 ? 
ATOM   693  C  CG    . ASN   A 1 91  ? 18.488  -1.310  -4.959  1.000 24.332 0 91  ASN   C CG    1 ? 
ATOM   694  O  OD1   . ASN   A 1 91  ? 18.228  -2.106  -4.052  1.000 27.642 0 91  ASN   C OD1   1 ? 
ATOM   695  N  ND2   . ASN   A 1 91  ? 19.354  -1.548  -5.929  1.000 26.979 0 91  ASN   C ND2   1 ? 
ATOM   696  N  N     . ARG   A 1 92  ? 20.172  2.084   -5.293  1.000 11.068 0 92  ARG   C N     1 ? 
ATOM   697  C  CA    . ARG   A 1 92  ? 21.526  2.385   -5.737  1.000 11.936 0 92  ARG   C CA    1 ? 
ATOM   698  C  C     . ARG   A 1 92  ? 22.372  2.913   -4.584  1.000 10.976 0 92  ARG   C C     1 ? 
ATOM   699  O  O     . ARG   A 1 92  ? 23.564  2.608   -4.431  1.000 12.142 0 92  ARG   C O     1 ? 
ATOM   700  C  CB    . ARG   A 1 92  ? 21.484  3.369   -6.897  1.000 14.795 0 92  ARG   C CB    1 ? 
ATOM   701  C  CG    . ARG   A 1 92  ? 22.844  3.630   -7.509  1.000 19.037 0 92  ARG   C CG    1 ? 
ATOM   702  C  CD    . ARG   A 1 92  ? 22.715  4.495   -8.745  1.000 21.968 0 92  ARG   C CD    1 ? 
ATOM   703  N  NE    . ARG   A 1 92  ? 22.731  5.903   -8.361  1.000 27.721 0 92  ARG   C NE    1 ? 
ATOM   704  C  CZ    . ARG   A 1 92  ? 21.829  6.817   -8.679  1.000 30.740 0 92  ARG   C CZ    1 ? 
ATOM   705  N  NH1   . ARG   A 1 92  ? 20.821  6.512   -9.479  1.000 39.225 0 92  ARG   C NH1   1 ? 
ATOM   706  N  NH2   . ARG   A 1 92  ? 21.960  8.045   -8.208  1.000 30.771 0 92  ARG   C NH2   1 ? 
ATOM   707  N  N     . ASN   A 1 93  ? 21.787  3.839   -3.814  1.000 10.205 0 93  ASN   C N     1 ? 
ATOM   708  C  CA    . ASN   A 1 93  ? 22.478  4.381   -2.675  1.000 10.225 0 93  ASN   C CA    1 ? 
ATOM   709  C  C     . ASN   A 1 93  ? 22.858  3.302   -1.642  1.000 9.717  0 93  ASN   C C     1 ? 
ATOM   710  O  O     . ASN   A 1 93  ? 23.976  3.316   -1.122  1.000 10.470 0 93  ASN   C O     1 ? 
ATOM   711  C  CB    . ASN   A 1 93  ? 21.635  5.458   -1.981  1.000 11.009 0 93  ASN   C CB    1 ? 
ATOM   712  C  CG    . ASN   A 1 93  ? 21.542  6.827   -2.625  1.000 11.790 0 93  ASN   C CG    1 ? 
ATOM   713  O  OD1   . ASN   A 1 93  ? 20.485  7.483   -2.709  1.000 11.829 0 93  ASN   C OD1   1 ? 
ATOM   714  N  ND2   . ASN   A 1 93  ? 22.680  7.295   -3.053  1.000 11.655 0 93  ASN   C ND2   1 ? 
ATOM   715  N  N     . ALA   A 1 94  ? 21.916  2.399   -1.308  1.000 9.463  0 94  ALA   C N     1 ? 
ATOM   716  C  CA    . ALA   A 1 94  ? 22.200  1.321   -0.365  1.000 10.013 0 94  ALA   C CA    1 ? 
ATOM   717  C  C     . ALA   A 1 94  ? 23.358  0.451   -0.873  1.000 10.245 0 94  ALA   C C     1 ? 
ATOM   718  O  O     . ALA   A 1 94  ? 24.238  0.097   -0.086  1.000 10.659 0 94  ALA   C O     1 ? 
ATOM   719  C  CB    . ALA   A 1 94  ? 20.933  0.521   -0.083  1.000 10.020 0 94  ALA   C CB    1 ? 
ATOM   720  N  N     . GLU   A 1 95  ? 23.327  0.140   -2.170  1.000 11.460 0 95  GLU   C N     1 ? 
ATOM   721  C  CA    . GLU   A 1 95  ? 24.380  -0.704  -2.751  1.000 13.286 0 95  GLU   C CA    1 ? 
ATOM   722  C  C     . GLU   A 1 95  ? 25.713  0.043   -2.700  1.000 12.785 0 95  GLU   C C     1 ? 
ATOM   723  O  O     . GLU   A 1 95  ? 26.741  -0.537  -2.320  1.000 14.230 0 95  GLU   C O     1 ? 
ATOM   724  C  CB    . GLU   A 1 95  ? 24.009  -1.064  -4.183  1.000 15.751 0 95  GLU   C CB    1 ? 
ATOM   725  C  CG    . GLU   A 1 95  ? 22.925  -2.128  -4.283  1.000 20.323 0 95  GLU   C CG    1 ? 
ATOM   726  C  CD    . GLU   A 1 95  ? 22.687  -2.654  -5.705  1.000 24.835 0 95  GLU   C CD    1 ? 
ATOM   727  O  OE1   . GLU   A 1 95  ? 23.338  -2.144  -6.648  1.000 39.041 0 95  GLU   C OE1   1 ? 
ATOM   728  O  OE2   . GLU   A 1 95  ? 21.877  -3.575  -5.882  1.000 31.004 0 95  GLU   C OE2   1 ? 
ATOM   729  N  N     . GLU   A 1 96  ? 25.751  1.369   -2.938  1.000 12.298 0 96  GLU   C N     1 ? 
ATOM   730  C  CA    . GLU   A 1 96  ? 26.995  2.121   -2.906  1.000 13.348 0 96  GLU   C CA    1 ? 
ATOM   731  C  C     . GLU   A 1 96  ? 27.618  2.116   -1.510  1.000 12.891 0 96  GLU   C C     1 ? 
ATOM   732  O  O     . GLU   A 1 96  ? 28.843  2.002   -1.375  1.000 14.639 0 96  GLU   C O     1 ? 
ATOM   733  C  CB    . GLU   A 1 96  ? 26.749  3.566   -3.373  1.000 15.032 0 96  GLU   C CB    1 ? 
ATOM   734  C  CG    . GLU   A 1 96  ? 27.953  4.488   -3.218  1.000 19.503 0 96  GLU   C CG    1 ? 
ATOM   735  C  CD    . GLU   A 1 96  ? 29.138  4.203   -4.138  1.000 26.856 0 96  GLU   C CD    1 ? 
ATOM   736  O  OE1   . GLU   A 1 96  ? 28.974  3.441   -5.128  1.000 28.506 0 96  GLU   C OE1   1 ? 
ATOM   737  O  OE2   . GLU   A 1 96  ? 30.237  4.744   -3.850  1.000 31.180 0 96  GLU   C OE2   1 ? 
ATOM   738  N  N     . PHE   A 1 97  ? 26.790  2.216   -0.465  1.000 11.199 0 97  PHE   C N     1 ? 
ATOM   739  C  CA    . PHE   A 1 97  ? 27.191  2.247   0.923   1.000 11.024 0 97  PHE   C CA    1 ? 
ATOM   740  C  C     . PHE   A 1 97  ? 27.442  0.823   1.466   1.000 10.621 0 97  PHE   C C     1 ? 
ATOM   741  O  O     . PHE   A 1 97  ? 27.878  0.659   2.607   1.000 11.622 0 97  PHE   C O     1 ? 
ATOM   742  C  CB    . PHE   A 1 97  ? 26.131  3.002   1.752   1.000 12.652 0 97  PHE   C CB    1 ? 
ATOM   743  C  CG    . PHE   A 1 97  ? 26.135  4.510   1.730   1.000 13.519 0 97  PHE   C CG    1 ? 
ATOM   744  C  CD1   . PHE   A 1 97  ? 25.828  5.199   0.566   1.000 14.619 0 97  PHE   C CD1   1 ? 
ATOM   745  C  CD2   . PHE   A 1 97  ? 26.267  5.214   2.893   1.000 12.237 0 97  PHE   C CD2   1 ? 
ATOM   746  C  CE1   . PHE   A 1 97  ? 25.768  6.597   0.569   1.000 16.083 0 97  PHE   C CE1   1 ? 
ATOM   747  C  CE2   . PHE   A 1 97  ? 26.246  6.605   2.871   1.000 13.612 0 97  PHE   C CE2   1 ? 
ATOM   748  C  CZ    . PHE   A 1 97  ? 26.033  7.273   1.709   1.000 14.741 0 97  PHE   C CZ    1 ? 
ATOM   749  N  N     . GLU   A 1 98  ? 27.124  -0.166  0.666   1.000 11.283 0 98  GLU   C N     1 ? 
ATOM   750  C  CA    . GLU   A 1 98  ? 27.334  -1.570  1.029   1.000 12.224 0 98  GLU   C CA    1 ? 
ATOM   751  C  C     . GLU   A 1 98  ? 26.456  -1.948  2.234   1.000 12.410 0 98  GLU   C C     1 ? 
ATOM   752  O  O     . GLU   A 1 98  ? 26.864  -2.651  3.147   1.000 14.355 0 98  GLU   C O     1 ? 
ATOM   753  C  CB    . GLU   A 1 98  ? 28.814  -1.886  1.292   1.000 13.944 0 98  GLU   C CB    1 ? 
ATOM   754  C  CG    . GLU   A 1 98  ? 29.723  -1.722  0.081   1.000 15.560 0 98  GLU   C CG    1 ? 
ATOM   755  C  CD    . GLU   A 1 98  ? 31.138  -2.142  0.422   1.000 20.468 0 98  GLU   C CD    1 ? 
ATOM   756  O  OE1   . GLU   A 1 98  ? 31.940  -1.259  0.834   1.000 20.220 0 98  GLU   C OE1   1 ? 
ATOM   757  O  OE2   . GLU   A 1 98  ? 31.413  -3.371  0.358   1.000 24.143 0 98  GLU   C OE2   1 ? 
ATOM   758  N  N     . LEU   A 1 99  ? 25.240  -1.390  2.303   1.000 10.473 0 99  LEU   C N     1 ? 
ATOM   759  C  CA    . LEU   A 1 99  ? 24.311  -1.612  3.403   1.000 11.732 0 99  LEU   C CA    1 ? 
ATOM   760  C  C     . LEU   A 1 99  ? 23.278  -2.650  3.003   1.000 12.154 0 99  LEU   C C     1 ? 
ATOM   761  O  O     . LEU   A 1 99  ? 22.545  -2.431  2.038   1.000 15.873 0 99  LEU   C O     1 ? 
ATOM   762  C  CB    . LEU   A 1 99  ? 23.609  -0.310  3.819   1.000 10.886 0 99  LEU   C CB    1 ? 
ATOM   763  C  CG    . LEU   A 1 99  ? 24.571  0.718   4.393   1.000 12.406 0 99  LEU   C CG    1 ? 
ATOM   764  C  CD1   . LEU   A 1 99  ? 23.941  2.093   4.476   1.000 13.209 0 99  LEU   C CD1   1 ? 
ATOM   765  C  CD2   . LEU   A 1 99  ? 25.091  0.316   5.756   1.000 12.956 0 99  LEU   C CD2   1 ? 
ATOM   766  N  N     . THR   A 1 100 ? 23.329  -3.829  3.649   1.000 10.966 0 100 THR   C N     1 ? 
ATOM   767  C  CA    . THR   A 1 100 ? 22.441  -4.921  3.266   1.000 11.776 0 100 THR   C CA    1 ? 
ATOM   768  C  C     . THR   A 1 100 ? 21.377  -5.197  4.323   1.000 11.036 0 100 THR   C C     1 ? 
ATOM   769  O  O     . THR   A 1 100 ? 20.578  -6.145  4.135   1.000 12.129 0 100 THR   C O     1 ? 
ATOM   770  C  CB    . THR   A 1 100 ? 23.236  -6.167  2.849   1.000 13.860 0 100 THR   C CB    1 ? 
ATOM   771  O  OG1   . THR   A 1 100 ? 23.976  -6.555  3.986   1.000 14.232 0 100 THR   C OG1   1 ? 
ATOM   772  C  CG2   . THR   A 1 100 ? 24.143  -5.932  1.653   1.000 14.913 0 100 THR   C CG2   1 ? 
ATOM   773  N  N     . ASN   A 1 101 ? 21.336  -4.434  5.398   1.000 8.788  0 101 ASN   C N     1 ? 
ATOM   774  C  CA    . ASN   A 1 101 ? 20.272  -4.505  6.386   1.000 8.124  0 101 ASN   C CA    1 ? 
ATOM   775  C  C     . ASN   A 1 101 ? 19.166  -3.502  6.043   1.000 8.151  0 101 ASN   C C     1 ? 
ATOM   776  O  O     . ASN   A 1 101 ? 18.586  -2.864  6.929   1.000 8.550  0 101 ASN   C O     1 ? 
ATOM   777  C  CB    . ASN   A 1 101 ? 20.869  -4.302  7.766   1.000 8.862  0 101 ASN   C CB    1 ? 
ATOM   778  C  CG    . ASN   A 1 101 ? 21.514  -2.936  7.948   1.000 8.673  0 101 ASN   C CG    1 ? 
ATOM   779  O  OD1   . ASN   A 1 101 ? 22.131  -2.430  7.007   1.000 9.211  0 101 ASN   C OD1   1 ? 
ATOM   780  N  ND2   . ASN   A 1 101 ? 21.562  -2.412  9.164   1.000 8.910  0 101 ASN   C ND2   1 ? 
ATOM   781  N  N     . ILE   A 1 102 ? 18.837  -3.395  4.762   1.000 8.374  0 102 ILE   C N     1 ? 
ATOM   782  C  CA    . ILE   A 1 102 ? 17.811  -2.529  4.200   1.000 8.396  0 102 ILE   C CA    1 ? 
ATOM   783  C  C     . ILE   A 1 102 ? 16.905  -3.315  3.287   1.000 8.552  0 102 ILE   C C     1 ? 
ATOM   784  O  O     . ILE   A 1 102 ? 17.419  -4.135  2.519   1.000 10.919 0 102 ILE   C O     1 ? 
ATOM   785  C  CB    . ILE   A 1 102 ? 18.444  -1.337  3.448   1.000 9.788  0 102 ILE   C CB    1 ? 
ATOM   786  C  CG1   . ILE   A 1 102 ? 19.143  -0.411  4.437   1.000 11.157 0 102 ILE   C CG1   1 ? 
ATOM   787  C  CG2   . ILE   A 1 102 ? 17.390  -0.611  2.616   1.000 10.743 0 102 ILE   C CG2   1 ? 
ATOM   788  C  CD1   . ILE   A 1 102 ? 19.876  0.778   3.837   1.000 12.397 0 102 ILE   C CD1   1 ? 
ATOM   789  N  N     . ASP   A 1 103 ? 15.594  -3.028  3.297   1.000 7.577  0 103 ASP   C N     1 ? 
ATOM   790  C  CA    . ASP   A 1 103 ? 14.698  -3.434  2.216   1.000 7.822  0 103 ASP   C CA    1 ? 
ATOM   791  C  C     . ASP   A 1 103 ? 13.798  -2.257  1.888   1.000 7.056  0 103 ASP   C C     1 ? 
ATOM   792  O  O     . ASP   A 1 103 ? 13.790  -1.196  2.555   1.000 7.108  0 103 ASP   C O     1 ? 
ATOM   793  C  CB    . ASP   A 1 103 ? 13.844  -4.657  2.563   1.000 8.135  0 103 ASP   C CB    1 ? 
ATOM   794  C  CG    . ASP   A 1 103 ? 14.277  -6.017  2.027   1.000 9.687  0 103 ASP   C CG    1 ? 
ATOM   795  O  OD1   . ASP   A 1 103 ? 15.172  -6.050  1.141   1.000 12.987 0 103 ASP   C OD1   1 ? 
ATOM   796  O  OD2   . ASP   A 1 103 ? 13.662  -6.990  2.377   1.000 9.787  0 103 ASP   C OD2   1 ? 
ATOM   797  N  N     . MET   A 1 104 ? 13.078  -2.367  0.759   1.000 7.629  0 104 MET   C N     1 ? 
ATOM   798  C  CA    . MET   A 1 104 ? 12.145  -1.311  0.410   1.000 9.083  0 104 MET   C CA    1 ? 
ATOM   799  C  C     . MET   A 1 104 ? 10.935  -1.850  -0.349  1.000 8.393  0 104 MET   C C     1 ? 
ATOM   800  O  O     . MET   A 1 104 ? 10.953  -2.950  -0.915  1.000 8.539  0 104 MET   C O     1 ? 
ATOM   801  C  CB    . MET   A 1 104 ? 12.832  -0.207  -0.368  1.000 12.603 0 104 MET   C CB    1 ? 
ATOM   802  C  CG    . MET   A 1 104 ? 13.538  -0.701  -1.585  1.000 11.682 0 104 MET   C CG    1 ? 
ATOM   803  S  SD    . MET   A 1 104 ? 14.772  0.454   -2.301  1.000 14.580 0 104 MET   C SD    1 ? 
ATOM   804  C  CE    . MET   A 1 104 ? 16.119  0.183   -1.162  1.000 15.658 0 104 MET   C CE    1 ? 
ATOM   805  N  N     . VAL   A 1 105 ? 9.863   -1.069  -0.225  1.000 7.514  0 105 VAL   C N     1 ? 
ATOM   806  C  CA    . VAL   A 1 105 ? 8.530   -1.461  -0.690  1.000 7.386  0 105 VAL   C CA    1 ? 
ATOM   807  C  C     . VAL   A 1 105 ? 7.823   -0.282  -1.312  1.000 7.215  0 105 VAL   C C     1 ? 
ATOM   808  O  O     . VAL   A 1 105 ? 7.865   0.806   -0.755  1.000 8.066  0 105 VAL   C O     1 ? 
ATOM   809  C  CB    . VAL   A 1 105 ? 7.712   -1.961  0.502   1.000 7.771  0 105 VAL   C CB    1 ? 
ATOM   810  C  CG1   . VAL   A 1 105 ? 6.290   -2.318  0.060   1.000 8.743  0 105 VAL   C CG1   1 ? 
ATOM   811  C  CG2   . VAL   A 1 105 ? 8.382   -3.147  1.142   1.000 8.074  0 105 VAL   C CG2   1 ? 
ATOM   812  N  N     . GLN   A 1 106 ? 7.221   -0.507  -2.490  1.000 6.613  0 106 GLN   C N     1 ? 
ATOM   813  C  CA    . GLN   A 1 106 ? 6.420   0.505   -3.166  1.000 7.650  0 106 GLN   C CA    1 ? 
ATOM   814  C  C     . GLN   A 1 106 ? 4.971   0.380   -2.752  1.000 7.200  0 106 GLN   C C     1 ? 
ATOM   815  O  O     . GLN   A 1 106 ? 4.383   -0.675  -2.878  1.000 7.634  0 106 GLN   C O     1 ? 
ATOM   816  C  CB    . GLN   A 1 106 ? 6.604   0.432   -4.686  1.000 7.640  0 106 GLN   C CB    1 ? 
ATOM   817  C  CG    . GLN   A 1 106 ? 5.845   1.520   -5.452  1.000 8.964  0 106 GLN   C CG    1 ? 
ATOM   818  C  CD    . GLN   A 1 106 ? 6.026   1.510   -6.945  1.000 9.902  0 106 GLN   C CD    1 ? 
ATOM   819  O  OE1   . GLN   A 1 106 ? 6.603   0.583   -7.508  1.000 11.771 0 106 GLN   C OE1   1 ? 
ATOM   820  N  NE2   . GLN   A 1 106 ? 5.501   2.538   -7.571  1.000 10.360 0 106 GLN   C NE2   1 ? 
ATOM   821  N  N     . CYS   A 1 107 ? 4.413   1.480   -2.225  1.000 7.799  0 107 CYS   C N     1 ? 
ATOM   822  C  CA    . CYS   A 1 107 ? 3.056   1.454   -1.672  1.000 8.662  0 107 CYS   C CA    1 ? 
ATOM   823  C  C     . CYS   A 1 107 ? 2.617   2.876   -1.405  1.000 8.067  0 107 CYS   C C     1 ? 
ATOM   824  O  O     . CYS   A 1 107 ? 3.395   3.827   -1.440  1.000 9.294  0 107 CYS   C O     1 ? 
ATOM   825  C  CB    . CYS   A 1 107 ? 2.944   0.640   -0.377  1.000 9.245  0 107 CYS   C CB    1 ? 
ATOM   826  S  SG    . CYS   A 1 107 ? 3.820   1.376   1.009   1.000 12.468 0 107 CYS   C SG    1 ? 
ATOM   827  N  N     . ASP   A 1 108 ? 1.328   2.988   -1.107  1.000 7.383  0 108 ASP   C N     1 ? 
ATOM   828  C  CA    . ASP   A 1 108 ? 0.715   4.259   -0.720  1.000 8.491  0 108 ASP   C CA    1 ? 
ATOM   829  C  C     . ASP   A 1 108 ? 0.495   4.224   0.787   1.000 8.202  0 108 ASP   C C     1 ? 
ATOM   830  O  O     . ASP   A 1 108 ? -0.359  3.494   1.282   1.000 9.189  0 108 ASP   C O     1 ? 
ATOM   831  C  CB    . ASP   A 1 108 ? -0.602  4.510   -1.459  1.000 8.406  0 108 ASP   C CB    1 ? 
ATOM   832  C  CG    . ASP   A 1 108 ? -1.197  5.874   -1.171  1.000 9.320  0 108 ASP   C CG    1 ? 
ATOM   833  O  OD1   . ASP   A 1 108 ? -0.867  6.435   -0.098  1.000 10.177 0 108 ASP   C OD1   1 ? 
ATOM   834  O  OD2   . ASP   A 1 108 ? -2.066  6.308   -1.961  1.000 11.295 0 108 ASP   C OD2   1 ? 
ATOM   835  N  N     . VAL   A 1 109 ? 1.306   4.964   1.545   1.000 8.101  0 109 VAL   C N     1 ? 
ATOM   836  C  CA    . VAL   A 1 109 ? 1.278   4.942   2.998   1.000 8.050  0 109 VAL   C CA    1 ? 
ATOM   837  C  C     . VAL   A 1 109 ? -0.097  5.353   3.523   1.000 9.245  0 109 VAL   C C     1 ? 
ATOM   838  O  O     . VAL   A 1 109 ? -0.461  4.946   4.641   1.000 9.991  0 109 VAL   C O     1 ? 
ATOM   839  C  CB    . VAL   A 1 109 ? 2.410   5.867   3.504   1.000 8.853  0 109 VAL   C CB    1 ? 
ATOM   840  C  CG1   . VAL   A 1 109 ? 2.242   6.264   4.969   1.000 8.763  0 109 VAL   C CG1   1 ? 
ATOM   841  C  CG2   . VAL   A 1 109 ? 3.728   5.159   3.241   1.000 8.564  0 109 VAL   C CG2   1 ? 
ATOM   842  N  N     . CYS   A 1 110 ? -0.860  6.149   2.767   1.000 9.537  0 110 CYS   C N     1 ? 
ATOM   843  C  CA    . CYS   A 1 110 ? -2.168  6.600   3.218   1.000 11.767 0 110 CYS   C CA    1 ? 
ATOM   844  C  C     . CYS   A 1 110 ? -3.235  5.530   3.049   1.000 12.324 0 110 CYS   C C     1 ? 
ATOM   845  O  O     . CYS   A 1 110 ? -4.342  5.726   3.560   1.000 14.613 0 110 CYS   C O     1 ? 
ATOM   846  C  CB    . CYS   A 1 110 ? -2.619  7.833   2.461   1.000 12.705 0 110 CYS   C CB    1 ? 
ATOM   847  S  SG    . CYS   A 1 110 ? -1.533  9.262   2.661   1.000 14.028 0 110 CYS   C SG    1 ? 
ATOM   848  N  N     . LEU   A 1 111 ? -2.908  4.351   2.521   1.000 10.060 0 111 LEU   C N     1 ? 
ATOM   849  C  CA    . LEU   A 1 111 ? -3.866  3.284   2.285   1.000 11.445 0 111 LEU   C CA    1 ? 
ATOM   850  C  C     . LEU   A 1 111 ? -3.406  1.982   2.955   1.000 12.000 0 111 LEU   C C     1 ? 
ATOM   851  O  O     . LEU   A 1 111 ? -3.806  0.875   2.588   1.000 14.335 0 111 LEU   C O     1 ? 
ATOM   852  C  CB    . LEU   A 1 111 ? -4.013  3.120   0.778   1.000 12.039 0 111 LEU   C CB    1 ? 
ATOM   853  C  CG    . LEU   A 1 111 ? -4.743  4.242   0.067   1.000 13.548 0 111 LEU   C CG    1 ? 
ATOM   854  C  CD1   . LEU   A 1 111 ? -4.739  4.075   -1.438  1.000 14.116 0 111 LEU   C CD1   1 ? 
ATOM   855  C  CD2   . LEU   A 1 111 ? -6.165  4.306   0.566   1.000 14.910 0 111 LEU   C CD2   1 ? 
ATOM   856  N  N     . LEU   A 1 112 ? -2.667  2.106   4.054   1.000 11.983 0 112 LEU   C N     1 ? 
ATOM   857  C  CA    . LEU   A 1 112 ? -2.162  0.945   4.785   1.000 12.707 0 112 LEU   C CA    1 ? 
ATOM   858  C  C     . LEU   A 1 112 ? -3.034  0.533   5.978   1.000 13.112 0 112 LEU   C C     1 ? 
ATOM   859  O  O     . LEU   A 1 112 ? -2.574  -0.195  6.857   1.000 14.174 0 112 LEU   C O     1 ? 
ATOM   860  C  CB    . LEU   A 1 112 ? -0.729  1.245   5.213   1.000 11.392 0 112 LEU   C CB    1 ? 
ATOM   861  C  CG    . LEU   A 1 112 ? 0.292   1.251   4.081   1.000 11.532 0 112 LEU   C CG    1 ? 
ATOM   862  C  CD1   . LEU   A 1 112 ? 1.709   1.433   4.589   1.000 11.449 0 112 LEU   C CD1   1 ? 
ATOM   863  C  CD2   . LEU   A 1 112 ? 0.254   -0.058  3.301   1.000 11.901 0 112 LEU   C CD2   1 ? 
ATOM   864  N  N     . SER   A 1 113 ? -4.317  0.911   6.043   1.000 16.604 0 113 SER   C N     1 ? 
ATOM   865  C  CA    . SER   A 1 113 ? -5.164  0.435   7.144   1.000 16.969 0 113 SER   C CA    1 ? 
ATOM   866  C  C     . SER   A 1 113 ? -5.039  -1.069  7.377   1.000 16.912 0 113 SER   C C     1 ? 
ATOM   867  O  O     . SER   A 1 113 ? -5.218  -1.844  6.448   1.000 17.766 0 113 SER   C O     1 ? 
ATOM   868  C  CB    . SER   A 1 113 ? -6.632  0.793   6.873   1.000 21.552 0 113 SER   C CB    1 ? 
ATOM   869  O  OG    . SER   A 1 113 ? -7.453  0.343   7.945   1.000 27.231 0 113 SER   C OG    1 ? 
ATOM   870  N  N     . ASN   A 1 114 ? -4.741  -1.461  8.625   1.000 14.334 0 114 ASN   C N     1 ? 
ATOM   871  C  CA    . ASN   A 1 114 ? -4.686  -2.854  9.077   1.000 17.105 0 114 ASN   C CA    1 ? 
ATOM   872  C  C     . ASN   A 1 114 ? -3.565  -3.656  8.440   1.000 14.345 0 114 ASN   C C     1 ? 
ATOM   873  O  O     . ASN   A 1 114 ? -3.580  -4.891  8.482   1.000 14.262 0 114 ASN   C O     1 ? 
ATOM   874  C  CB    . ASN   A 1 114 ? -5.982  -3.627  8.874   1.000 20.856 0 114 ASN   C CB    1 ? 
ATOM   875  C  CG    . ASN   A 1 114 ? -7.101  -3.072  9.714   1.000 23.860 0 114 ASN   C CG    1 ? 
ATOM   876  O  OD1   . ASN   A 1 114 ? -8.117  -2.660  9.162   1.000 30.803 0 114 ASN   C OD1   1 ? 
ATOM   877  N  ND2   . ASN   A 1 114 ? -6.898  -3.032  11.015  1.000 28.566 0 114 ASN   C ND2   1 ? 
ATOM   878  N  N     . ARG   A 1 115 ? -2.580  -2.968  7.851   1.000 11.639 0 115 ARG   C N     1 ? 
ATOM   879  C  CA    . ARG   A 1 115 ? -1.427  -3.635  7.260   1.000 10.909 0 115 ARG   C CA    1 ? 
ATOM   880  C  C     . ARG   A 1 115 ? -0.235  -3.411  8.182   1.000 10.703 0 115 ARG   C C     1 ? 
ATOM   881  O  O     . ARG   A 1 115 ? 0.001   -2.285  8.670   1.000 10.869 0 115 ARG   C O     1 ? 
ATOM   882  C  CB    . ARG   A 1 115 ? -1.100  -3.100  5.865   1.000 9.994  0 115 ARG   C CB    1 ? 
ATOM   883  C  CG    . ARG   A 1 115 ? -2.263  -3.083  4.878   1.000 10.874 0 115 ARG   C CG    1 ? 
ATOM   884  C  CD    . ARG   A 1 115 ? -2.908  -4.456  4.707   1.000 11.261 0 115 ARG   C CD    1 ? 
ATOM   885  N  NE    . ARG   A 1 115 ? -3.945  -4.464  3.666   1.000 11.730 0 115 ARG   C NE    1 ? 
ATOM   886  C  CZ    . ARG   A 1 115 ? -4.486  -5.557  3.161   1.000 12.745 0 115 ARG   C CZ    1 ? 
ATOM   887  N  NH1   . ARG   A 1 115 ? -4.006  -6.749  3.472   1.000 12.393 0 115 ARG   C NH1   1 ? 
ATOM   888  N  NH2   . ARG   A 1 115 ? -5.427  -5.423  2.242   1.000 14.537 0 115 ARG   C NH2   1 ? 
ATOM   889  N  N     . MET   A 1 116 ? 0.515   -4.485  8.407   1.000 9.088  0 116 MET   C N     1 ? 
ATOM   890  C  CA    . MET   A 1 116 ? 1.715   -4.474  9.216   1.000 9.429  0 116 MET   C CA    1 ? 
ATOM   891  C  C     . MET   A 1 116 ? 1.423   -3.836  10.571  1.000 8.840  0 116 MET   C C     1 ? 
ATOM   892  O  O     . MET   A 1 116 ? 2.266   -3.149  11.140  1.000 8.502  0 116 MET   C O     1 ? 
ATOM   893  C  CB    . MET   A 1 116 ? 2.782   -3.647  8.486   1.000 9.089  0 116 MET   C CB    1 ? 
ATOM   894  C  CG    . MET   A 1 116 ? 3.160   -4.192  7.129   1.000 9.413  0 116 MET   C CG    1 ? 
ATOM   895  S  SD    . MET   A 1 116 ? 4.340   -3.204  6.153   1.000 9.927  0 116 MET   C SD    1 ? 
ATOM   896  C  CE    . MET   A 1 116 ? 3.217   -1.902  5.637   1.000 9.575  0 116 MET   C CE    1 ? 
ATOM   897  N  N     . SER   A 1 117 ? 0.278   -4.193  11.175  1.000 8.974  0 117 SER   C N     1 ? 
ATOM   898  C  CA    . SER   A 1 117 ? -0.067  -3.677  12.476  1.000 9.111  0 117 SER   C CA    1 ? 
ATOM   899  C  C     . SER   A 1 117 ? 0.909   -4.109  13.551  1.000 8.134  0 117 SER   C C     1 ? 
ATOM   900  O  O     . SER   A 1 117 ? 1.174   -5.295  13.722  1.000 8.322  0 117 SER   C O     1 ? 
ATOM   901  C  CB    . SER   A 1 117 ? -1.480  -4.045  12.831  1.000 10.286 0 117 SER   C CB    1 ? 
ATOM   902  O  OG    . SER   A 1 117 ? -2.371  -3.613  11.816  1.000 14.141 0 117 SER   C OG    1 ? 
ATOM   903  N  N     . LYS   A 1 118 ? 1.521   -3.142  14.219  1.000 7.483  0 118 LYS   C N     1 ? 
ATOM   904  C  CA    . LYS   A 1 118 ? 2.436   -3.411  15.313  1.000 7.846  0 118 LYS   C CA    1 ? 
ATOM   905  C  C     . LYS   A 1 118 ? 3.534   -4.365  14.860  1.000 8.344  0 118 LYS   C C     1 ? 
ATOM   906  O  O     . LYS   A 1 118 ? 4.026   -5.160  15.647  1.000 10.289 0 118 LYS   C O     1 ? 
ATOM   907  C  CB    . LYS   A 1 118 ? 1.664   -3.856  16.558  1.000 9.303  0 118 LYS   C CB    1 ? 
ATOM   908  C  CG    . LYS   A 1 118 ? 0.644   -2.859  17.055  1.000 8.665  0 118 LYS   C CG    1 ? 
ATOM   909  C  CD    . LYS   A 1 118 ? 1.234   -1.503  17.396  1.000 9.717  0 118 LYS   C CD    1 ? 
ATOM   910  C  CE    . LYS   A 1 118 ? 0.180   -0.499  17.755  1.000 9.545  0 118 LYS   C CE    1 ? 
ATOM   911  N  NZ    . LYS   A 1 118 ? 0.740   0.817   18.191  1.000 10.643 0 118 LYS   C NZ    1 ? 
ATOM   912  N  N     . SER   A 1 119 ? 4.014   -4.203  13.613  1.000 8.684  0 119 SER   C N     1 ? 
ATOM   913  C  CA    . SER   A 1 119 ? 5.065   -5.040  13.052  1.000 9.023  0 119 SER   C CA    1 ? 
ATOM   914  C  C     . SER   A 1 119 ? 6.448   -4.417  13.207  1.000 8.854  0 119 SER   C C     1 ? 
ATOM   915  O  O     . SER   A 1 119 ? 7.445   -5.047  12.877  1.000 10.445 0 119 SER   C O     1 ? 
ATOM   916  C  CB    . SER   A 1 119 ? 4.846   -5.249  11.623  1.000 9.283  0 119 SER   C CB    1 ? 
ATOM   917  O  OG    . SER   A 1 119 ? 3.708   -6.057  11.368  1.000 11.367 0 119 SER   C OG    1 ? 
ATOM   918  N  N     . PHE   A 1 120 ? 6.548   -3.142  13.527  1.000 7.119  0 120 PHE   C N     1 ? 
ATOM   919  C  CA    . PHE   A 1 120 ? 7.844   -2.442  13.603  1.000 7.819  0 120 PHE   C CA    1 ? 
ATOM   920  C  C     . PHE   A 1 120 ? 8.097   -1.934  15.013  1.000 7.405  0 120 PHE   C C     1 ? 
ATOM   921  O  O     . PHE   A 1 120 ? 7.145   -1.584  15.714  1.000 8.195  0 120 PHE   C O     1 ? 
ATOM   922  C  CB    . PHE   A 1 120 ? 7.887   -1.292  12.590  1.000 7.873  0 120 PHE   C CB    1 ? 
ATOM   923  C  CG    . PHE   A 1 120 ? 8.024   -1.777  11.188  1.000 7.057  0 120 PHE   C CG    1 ? 
ATOM   924  C  CD1   . PHE   A 1 120 ? 9.266   -1.948  10.610  1.000 7.695  0 120 PHE   C CD1   1 ? 
ATOM   925  C  CD2   . PHE   A 1 120 ? 6.934   -2.030  10.403  1.000 7.615  0 120 PHE   C CD2   1 ? 
ATOM   926  C  CE1   . PHE   A 1 120 ? 9.393   -2.419  9.320   1.000 8.098  0 120 PHE   C CE1   1 ? 
ATOM   927  C  CE2   . PHE   A 1 120 ? 7.049   -2.542  9.127   1.000 8.564  0 120 PHE   C CE2   1 ? 
ATOM   928  C  CZ    . PHE   A 1 120 ? 8.289   -2.746  8.576   1.000 7.646  0 120 PHE   C CZ    1 ? 
ATOM   929  N  N     . ASP   A 1 121 ? 9.346   -1.905  15.466  1.000 7.776  0 121 ASP   C N     1 ? 
ATOM   930  C  CA    . ASP   A 1 121 ? 9.689   -1.248  16.727  1.000 7.778  0 121 ASP   C CA    1 ? 
ATOM   931  C  C     . ASP   A 1 121 ? 9.470   0.265   16.666  1.000 8.092  0 121 ASP   C C     1 ? 
ATOM   932  O  O     . ASP   A 1 121 ? 8.904   0.876   17.572  1.000 9.157  0 121 ASP   C O     1 ? 
ATOM   933  C  CB    . ASP   A 1 121 ? 11.123  -1.580  17.141  1.000 7.961  0 121 ASP   C CB    1 ? 
ATOM   934  C  CG    . ASP   A 1 121 ? 11.355  -3.067  17.342  1.000 7.976  0 121 ASP   C CG    1 ? 
ATOM   935  O  OD1   . ASP   A 1 121 ? 10.543  -3.649  18.121  1.000 9.827  0 121 ASP   C OD1   1 ? 
ATOM   936  O  OD2   . ASP   A 1 121 ? 12.266  -3.649  16.744  1.000 9.464  0 121 ASP   C OD2   1 ? 
ATOM   937  N  N     . THR   A 1 122 ? 10.018  0.835   15.594  1.000 7.451  0 122 THR   C N     1 ? 
ATOM   938  C  CA    . THR   A 1 122 ? 10.187  2.269   15.444  1.000 7.030  0 122 THR   C CA    1 ? 
ATOM   939  C  C     . THR   A 1 122 ? 9.737   2.633   14.045  1.000 6.947  0 122 THR   C C     1 ? 
ATOM   940  O  O     . THR   A 1 122 ? 10.131  1.948   13.092  1.000 7.412  0 122 THR   C O     1 ? 
ATOM   941  C  CB    . THR   A 1 122 ? 11.649  2.682   15.661  1.000 7.673  0 122 THR   C CB    1 ? 
ATOM   942  O  OG1   . THR   A 1 122 ? 12.053  2.217   16.953  1.000 8.224  0 122 THR   C OG1   1 ? 
ATOM   943  C  CG2   . THR   A 1 122 ? 11.840  4.183   15.603  1.000 7.847  0 122 THR   C CG2   1 ? 
ATOM   944  N  N     . VAL   A 1 123 ? 9.076   3.799   13.881  1.000 6.851  0 123 VAL   C N     1 ? 
ATOM   945  C  CA    . VAL   A 1 123 ? 8.811   4.356   12.557  1.000 7.329  0 123 VAL   C CA    1 ? 
ATOM   946  C  C     . VAL   A 1 123 ? 9.414   5.758   12.546  1.000 8.344  0 123 VAL   C C     1 ? 
ATOM   947  O  O     . VAL   A 1 123 ? 9.308   6.520   13.534  1.000 9.054  0 123 VAL   C O     1 ? 
ATOM   948  C  CB    . VAL   A 1 123 ? 7.295   4.375   12.262  1.000 8.480  0 123 VAL   C CB    1 ? 
ATOM   949  C  CG1   . VAL   A 1 123 ? 6.927   5.021   10.931  1.000 10.667 0 123 VAL   C CG1   1 ? 
ATOM   950  C  CG2   . VAL   A 1 123 ? 6.742   2.981   12.321  1.000 9.304  0 123 VAL   C CG2   1 ? 
ATOM   951  N  N     . ILE   A 1 124 ? 10.087  6.105   11.440  1.000 7.931  0 124 ILE   C N     1 ? 
ATOM   952  C  CA    . ILE   A 1 124 ? 10.692  7.412   11.260  1.000 8.576  0 124 ILE   C CA    1 ? 
ATOM   953  C  C     . ILE   A 1 124 ? 10.200  7.939   9.915   1.000 8.418  0 124 ILE   C C     1 ? 
ATOM   954  O  O     . ILE   A 1 124 ? 9.811   7.167   9.031   1.000 9.555  0 124 ILE   C O     1 ? 
ATOM   955  C  CB    . ILE   A 1 124 ? 12.236  7.333   11.255  1.000 9.239  0 124 ILE   C CB    1 ? 
ATOM   956  C  CG1   . ILE   A 1 124 ? 12.732  6.573   10.030  1.000 10.800 0 124 ILE   C CG1   1 ? 
ATOM   957  C  CG2   . ILE   A 1 124 ? 12.787  6.789   12.560  1.000 8.705  0 124 ILE   C CG2   1 ? 
ATOM   958  C  CD1   . ILE   A 1 124 ? 14.242  6.285   10.035  1.000 11.163 0 124 ILE   C CD1   1 ? 
ATOM   959  N  N     . MET   A 1 125 ? 10.088  9.280   9.770   1.000 8.040  0 125 MET   C N     1 ? 
ATOM   960  C  CA    . MET   A 1 125 ? 9.590   9.839   8.531   1.000 7.980  0 125 MET   C CA    1 ? 
ATOM   961  C  C     . MET   A 1 125 ? 9.828   11.355  8.471   1.000 8.166  0 125 MET   C C     1 ? 
ATOM   962  O  O     . MET   A 1 125 ? 9.804   12.036  9.474   1.000 8.896  0 125 MET   C O     1 ? 
ATOM   963  C  CB    . MET   A 1 125 ? 8.093   9.572   8.339   1.000 8.440  0 125 MET   C CB    1 ? 
ATOM   964  C  CG    . MET   A 1 125 ? 7.251   9.884   9.557   1.000 8.080  0 125 MET   C CG    1 ? 
ATOM   965  S  SD    . MET   A 1 125 ? 5.546   9.350   9.184   1.000 11.188 0 125 MET   C SD    1 ? 
ATOM   966  C  CE    . MET   A 1 125 ? 4.668   9.948   10.608  1.000 9.769  0 125 MET   C CE    1 ? 
ATOM   967  N  N     . ASN   A 1 126 ? 9.926   11.815  7.231   1.000 7.787  0 126 ASN   C N     1 ? 
ATOM   968  C  CA    . ASN   A 1 126 ? 9.901   13.229  6.857   1.000 8.439  0 126 ASN   C CA    1 ? 
ATOM   969  C  C     . ASN   A 1 126 ? 8.768   13.356  5.849   1.000 8.226  0 126 ASN   C C     1 ? 
ATOM   970  O  O     . ASN   A 1 126 ? 8.984   13.344  4.622   1.000 8.385  0 126 ASN   C O     1 ? 
ATOM   971  C  CB    . ASN   A 1 126 ? 11.242  13.640  6.257   1.000 8.609  0 126 ASN   C CB    1 ? 
ATOM   972  C  CG    . ASN   A 1 126 ? 11.459  15.106  5.950   1.000 10.021 0 126 ASN   C CG    1 ? 
ATOM   973  O  OD1   . ASN   A 1 126 ? 10.675  16.038  6.232   1.000 12.790 0 126 ASN   C OD1   1 ? 
ATOM   974  N  ND2   . ASN   A 1 126 ? 12.620  15.354  5.410   1.000 9.092  0 126 ASN   C ND2   1 ? 
ATOM   975  N  N     . PRO   A 1 127 ? 7.494   13.397  6.305   1.000 8.662  0 127 PRO   C N     1 ? 
ATOM   976  C  CA    . PRO   A 1 127 ? 6.376   13.275  5.379   1.000 9.263  0 127 PRO   C CA    1 ? 
ATOM   977  C  C     . PRO   A 1 127 ? 6.090   14.515  4.549   1.000 8.638  0 127 PRO   C C     1 ? 
ATOM   978  O  O     . PRO   A 1 127 ? 6.436   15.648  4.915   1.000 9.171  0 127 PRO   C O     1 ? 
ATOM   979  C  CB    . PRO   A 1 127 ? 5.178   13.014  6.269   1.000 10.623 0 127 PRO   C CB    1 ? 
ATOM   980  C  CG    . PRO   A 1 127 ? 5.585   13.619  7.568   1.000 10.639 0 127 PRO   C CG    1 ? 
ATOM   981  C  CD    . PRO   A 1 127 ? 7.071   13.366  7.725   1.000 9.684  0 127 PRO   C CD    1 ? 
ATOM   982  N  N     . PRO   A 1 128 ? 5.338   14.341  3.450   1.000 9.022  0 128 PRO   C N     1 ? 
ATOM   983  C  CA    . PRO   A 1 128 ? 4.720   15.462  2.734   1.000 9.458  0 128 PRO   C CA    1 ? 
ATOM   984  C  C     . PRO   A 1 128 ? 3.684   16.165  3.601   1.000 9.790  0 128 PRO   C C     1 ? 
ATOM   985  O  O     . PRO   A 1 128 ? 3.150   15.601  4.543   1.000 10.079 0 128 PRO   C O     1 ? 
ATOM   986  C  CB    . PRO   A 1 128 ? 3.996   14.846  1.552   1.000 10.705 0 128 PRO   C CB    1 ? 
ATOM   987  C  CG    . PRO   A 1 128 ? 4.426   13.419  1.503   1.000 11.835 0 128 PRO   C CG    1 ? 
ATOM   988  C  CD    . PRO   A 1 128 ? 4.922   13.038  2.893   1.000 9.937  0 128 PRO   C CD    1 ? 
ATOM   989  N  N     . PHE   A 1 129 ? 3.406   17.445  3.244   1.000 10.023 0 129 PHE   C N     1 ? 
ATOM   990  C  CA    . PHE   A 1 129 ? 2.461   18.297  3.962   1.000 11.307 0 129 PHE   C CA    1 ? 
ATOM   991  C  C     . PHE   A 1 129 ? 1.190   18.669  3.211   1.000 11.932 0 129 PHE   C C     1 ? 
ATOM   992  O  O     . PHE   A 1 129 ? 0.263   19.207  3.819   1.000 13.754 0 129 PHE   C O     1 ? 
ATOM   993  C  CB    . PHE   A 1 129 ? 3.153   19.577  4.416   1.000 12.058 0 129 PHE   C CB    1 ? 
ATOM   994  C  CG    . PHE   A 1 129 ? 4.314   19.321  5.342   1.000 13.705 0 129 PHE   C CG    1 ? 
ATOM   995  C  CD1   . PHE   A 1 129 ? 4.076   18.692  6.549   1.000 15.915 0 129 PHE   C CD1   1 ? 
ATOM   996  C  CD2   . PHE   A 1 129 ? 5.594   19.769  5.056   1.000 14.520 0 129 PHE   C CD2   1 ? 
ATOM   997  C  CE1   . PHE   A 1 129 ? 5.121   18.461  7.419   1.000 15.373 0 129 PHE   C CE1   1 ? 
ATOM   998  C  CE2   . PHE   A 1 129 ? 6.636   19.530  5.944   1.000 17.576 0 129 PHE   C CE2   1 ? 
ATOM   999  C  CZ    . PHE   A 1 129 ? 6.383   18.873  7.095   1.000 16.324 0 129 PHE   C CZ    1 ? 
ATOM   1000 N  N     . GLY   A 1 130 ? 1.106   18.354  1.941   1.000 10.675 0 130 GLY   C N     1 ? 
ATOM   1001 C  CA    . GLY   A 1 130 ? -0.029  18.745  1.111   1.000 10.865 0 130 GLY   C CA    1 ? 
ATOM   1002 C  C     . GLY   A 1 130 ? -1.363  18.275  1.690   1.000 11.552 0 130 GLY   C C     1 ? 
ATOM   1003 O  O     . GLY   A 1 130 ? -1.448  17.179  2.249   1.000 12.504 0 130 GLY   C O     1 ? 
ATOM   1004 N  N     . THR   A 1 131 ? -2.437  19.011  1.436   1.000 11.257 0 131 THR   C N     1 ? 
ATOM   1005 C  CA    . THR   A 1 131 ? -3.771  18.621  1.842   1.000 11.639 0 131 THR   C CA    1 ? 
ATOM   1006 C  C     . THR   A 1 131 ? -4.180  17.342  1.115   1.000 13.830 0 131 THR   C C     1 ? 
ATOM   1007 O  O     . THR   A 1 131 ? -4.095  17.279  -0.107  1.000 15.346 0 131 THR   C O     1 ? 
ATOM   1008 C  CB    . THR   A 1 131 ? -4.787  19.726  1.539   1.000 12.387 0 131 THR   C CB    1 ? 
ATOM   1009 O  OG1   . THR   A 1 131 ? -4.357  20.861  2.283   1.000 14.580 0 131 THR   C OG1   1 ? 
ATOM   1010 C  CG2   . THR   A 1 131 ? -6.206  19.284  1.838   1.000 13.831 0 131 THR   C CG2   1 ? 
ATOM   1011 N  N     . LYS   A 1 132 ? -4.653  16.329  1.841   1.000 13.168 0 132 LYS   C N     1 ? 
ATOM   1012 C  CA    . LYS   A 1 132 ? -5.171  15.092  1.266   1.000 14.242 0 132 LYS   C CA    1 ? 
ATOM   1013 C  C     . LYS   A 1 132 ? -6.448  14.778  2.021   1.000 13.394 0 132 LYS   C C     1 ? 
ATOM   1014 O  O     . LYS   A 1 132 ? -6.478  14.643  3.227   1.000 13.567 0 132 LYS   C O     1 ? 
ATOM   1015 C  CB    . LYS   A 1 132 ? -4.111  14.003  1.354   1.000 19.651 0 132 LYS   C CB    1 ? 
ATOM   1016 C  CG    . LYS   A 1 132 ? -4.455  12.738  0.591   1.000 23.773 0 132 LYS   C CG    1 ? 
ATOM   1017 C  CD    . LYS   A 1 132 ? -3.299  11.778  0.610   1.000 28.238 0 132 LYS   C CD    1 ? 
ATOM   1018 C  CE    . LYS   A 1 132 ? -3.589  10.503  -0.155  1.000 30.901 0 132 LYS   C CE    1 ? 
ATOM   1019 N  NZ    . LYS   A 1 132 ? -3.707  10.786  -1.600  1.000 33.075 0 132 LYS   C NZ    1 ? 
ATOM   1020 N  N     . ASN   A 1 133 ? -7.564  14.804  1.297   1.000 14.265 0 133 ASN   C N     1 ? 
ATOM   1021 C  CA    . ASN   A 1 133 ? -8.881  14.663  1.928   1.000 18.286 0 133 ASN   C CA    1 ? 
ATOM   1022 C  C     . ASN   A 1 133 ? -9.075  15.502  3.203   1.000 20.403 0 133 ASN   C C     1 ? 
ATOM   1023 O  O     . ASN   A 1 133 ? -9.298  14.974  4.289   1.000 24.056 0 133 ASN   C O     1 ? 
ATOM   1024 C  CB    . ASN   A 1 133 ? -9.156  13.276  2.514   1.000 21.948 0 133 ASN   C CB    1 ? 
ATOM   1025 C  CG    . ASN   A 1 133 ? -9.060  12.164  1.503   1.000 25.123 0 133 ASN   C CG    1 ? 
ATOM   1026 O  OD1   . ASN   A 1 133 ? -9.505  12.326  0.375   1.000 28.992 0 133 ASN   C OD1   1 ? 
ATOM   1027 N  ND2   . ASN   A 1 133 ? -8.413  11.074  1.874   1.000 32.247 0 133 ASN   C ND2   1 ? 
ATOM   1028 N  N     . ASN   A 1 134 ? -8.963  16.791  3.107   1.000 20.975 0 134 ASN   C N     1 ? 
ATOM   1029 C  CA    . ASN   A 1 134 ? -9.238  17.703  4.217   1.000 16.359 0 134 ASN   C CA    1 ? 
ATOM   1030 C  C     . ASN   A 1 134 ? -8.177  17.780  5.321   1.000 18.026 0 134 ASN   C C     1 ? 
ATOM   1031 O  O     . ASN   A 1 134 ? -8.281  18.657  6.173   1.000 21.783 0 134 ASN   C O     1 ? 
ATOM   1032 C  CB    . ASN   A 1 134 ? -10.574 17.489  4.935   1.000 15.071 0 134 ASN   C CB    1 ? 
ATOM   1033 C  CG    . ASN   A 1 134 ? -11.053 18.814  5.494   1.000 14.389 0 134 ASN   C CG    1 ? 
ATOM   1034 O  OD1   . ASN   A 1 134 ? -11.012 19.807  4.791   1.000 13.715 0 134 ASN   C OD1   1 ? 
ATOM   1035 N  ND2   . ASN   A 1 134 ? -11.387 18.875  6.765   1.000 15.284 0 134 ASN   C ND2   1 ? 
ATOM   1036 N  N     . LYS   A 1 135 ? -7.119  16.962  5.306   1.000 14.800 0 135 LYS   C N     1 ? 
ATOM   1037 C  CA    . LYS   A 1 135 ? -6.107  17.067  6.357   1.000 16.382 0 135 LYS   C CA    1 ? 
ATOM   1038 C  C     . LYS   A 1 135 ? -4.726  17.008  5.710   1.000 13.007 0 135 LYS   C C     1 ? 
ATOM   1039 O  O     . LYS   A 1 135 ? -4.567  16.622  4.553   1.000 12.445 0 135 LYS   C O     1 ? 
ATOM   1040 C  CB    . LYS   A 1 135 ? -6.294  15.971  7.411   1.000 19.275 0 135 LYS   C CB    1 ? 
ATOM   1041 C  CG    . LYS   A 1 135 ? -6.075  14.544  6.928   1.000 23.870 0 135 LYS   C CG    1 ? 
ATOM   1042 C  CD    . LYS   A 1 135 ? -6.208  13.434  7.985   1.000 29.889 0 135 LYS   C CD    1 ? 
ATOM   1043 C  CE    . LYS   A 1 135 ? -6.123  12.061  7.345   1.000 32.561 0 135 LYS   C CE    1 ? 
ATOM   1044 N  NZ    . LYS   A 1 135 ? -6.253  10.936  8.305   1.000 36.703 0 135 LYS   C NZ    1 ? 
ATOM   1045 N  N     . GLY   A 1 136 ? -3.698  17.371  6.483   1.000 11.867 0 136 GLY   C N     1 ? 
ATOM   1046 C  CA    . GLY   A 1 136 ? -2.334  17.272  5.992   1.000 11.340 0 136 GLY   C CA    1 ? 
ATOM   1047 C  C     . GLY   A 1 136 ? -1.966  15.823  5.695   1.000 10.317 0 136 GLY   C C     1 ? 
ATOM   1048 O  O     . GLY   A 1 136 ? -2.328  14.922  6.448   1.000 10.422 0 136 GLY   C O     1 ? 
ATOM   1049 N  N     . THR   A 1 137 ? -1.250  15.612  4.572   1.000 8.508  0 137 THR   C N     1 ? 
ATOM   1050 C  CA    . THR   A 1 137 ? -0.760  14.271  4.277   1.000 8.676  0 137 THR   C CA    1 ? 
ATOM   1051 C  C     . THR   A 1 137 ? 0.054   13.755  5.457   1.000 8.434  0 137 THR   C C     1 ? 
ATOM   1052 O  O     . THR   A 1 137 ? 0.062   12.544  5.717   1.000 8.361  0 137 THR   C O     1 ? 
ATOM   1053 C  CB    . THR   A 1 137 ? 0.071   14.277  2.995   1.000 9.157  0 137 THR   C CB    1 ? 
ATOM   1054 O  OG1   . THR   A 1 137 ? -0.778  14.611  1.885   1.000 11.360 0 137 THR   C OG1   1 ? 
ATOM   1055 C  CG2   . THR   A 1 137 ? 0.638   12.915  2.704   1.000 9.877  0 137 THR   C CG2   1 ? 
ATOM   1056 N  N     . ASP   A 1 138 ? 0.768   14.612  6.148   1.000 8.526  0 138 ASP   C N     1 ? 
ATOM   1057 C  CA    . ASP   A 1 138 ? 1.589   14.236  7.304   1.000 8.649  0 138 ASP   C CA    1 ? 
ATOM   1058 C  C     . ASP   A 1 138 ? 0.741   13.604  8.407   1.000 8.758  0 138 ASP   C C     1 ? 
ATOM   1059 O  O     . ASP   A 1 138 ? 1.253   12.751  9.143   1.000 8.899  0 138 ASP   C O     1 ? 
ATOM   1060 C  CB    . ASP   A 1 138 ? 2.375   15.442  7.804   1.000 9.351  0 138 ASP   C CB    1 ? 
ATOM   1061 C  CG    . ASP   A 1 138 ? 1.540   16.638  8.237   1.000 10.326 0 138 ASP   C CG    1 ? 
ATOM   1062 O  OD1   . ASP   A 1 138 ? 0.722   17.047  7.418   1.000 11.877 0 138 ASP   C OD1   1 ? 
ATOM   1063 O  OD2   . ASP   A 1 138 ? 1.744   17.152  9.355   1.000 12.474 0 138 ASP   C OD2   1 ? 
ATOM   1064 N  N     . MET   A 1 139 ? -0.521  14.028  8.556   1.000 8.378  0 139 MET   C N     1 ? 
ATOM   1065 C  CA    . MET   A 1 139 ? -1.419  13.452  9.551   1.000 8.758  0 139 MET   C CA    1 ? 
ATOM   1066 C  C     . MET   A 1 139 ? -1.896  12.052  9.133   1.000 8.275  0 139 MET   C C     1 ? 
ATOM   1067 O  O     . MET   A 1 139 ? -2.132  11.196  9.985   1.000 9.597  0 139 MET   C O     1 ? 
ATOM   1068 C  CB    . MET   A 1 139 ? -2.584  14.394  9.858   1.000 10.773 0 139 MET   C CB    1 ? 
ATOM   1069 C  CG    . MET   A 1 139 ? -2.086  15.687  10.447  1.000 13.795 0 139 MET   C CG    1 ? 
ATOM   1070 S  SD    . MET   A 1 139 ? -1.088  15.553  11.964  1.000 17.433 0 139 MET   C SD    1 ? 
ATOM   1071 C  CE    . MET   A 1 139 ? -2.322  15.016  13.120  1.000 18.574 0 139 MET   C CE    1 ? 
ATOM   1072 N  N     . ALA   A 1 140 ? -2.098  11.823  7.821   1.000 8.570  0 140 ALA   C N     1 ? 
ATOM   1073 C  CA    . ALA   A 1 140 ? -2.390  10.490  7.342   1.000 8.083  0 140 ALA   C CA    1 ? 
ATOM   1074 C  C     . ALA   A 1 140 ? -1.185  9.597   7.609   1.000 7.970  0 140 ALA   C C     1 ? 
ATOM   1075 O  O     . ALA   A 1 140 ? -1.324  8.426   7.979   1.000 9.441  0 140 ALA   C O     1 ? 
ATOM   1076 C  CB    . ALA   A 1 140 ? -2.768  10.514  5.858   1.000 9.068  0 140 ALA   C CB    1 ? 
ATOM   1077 N  N     . PHE   A 1 141 ? 0.011   10.076  7.278   1.000 7.318  0 141 PHE   C N     1 ? 
ATOM   1078 C  CA    . PHE   A 1 141 ? 1.234   9.298   7.538   1.000 7.077  0 141 PHE   C CA    1 ? 
ATOM   1079 C  C     . PHE   A 1 141 ? 1.344   8.968   9.025   1.000 7.527  0 141 PHE   C C     1 ? 
ATOM   1080 O  O     . PHE   A 1 141 ? 1.723   7.838   9.371   1.000 8.115  0 141 PHE   C O     1 ? 
ATOM   1081 C  CB    . PHE   A 1 141 ? 2.470   10.106  7.100   1.000 8.091  0 141 PHE   C CB    1 ? 
ATOM   1082 C  CG    . PHE   A 1 141 ? 2.922   9.901   5.672   1.000 7.439  0 141 PHE   C CG    1 ? 
ATOM   1083 C  CD1   . PHE   A 1 141 ? 2.073   9.998   4.589   1.000 7.991  0 141 PHE   C CD1   1 ? 
ATOM   1084 C  CD2   . PHE   A 1 141 ? 4.234   9.520   5.406   1.000 7.735  0 141 PHE   C CD2   1 ? 
ATOM   1085 C  CE1   . PHE   A 1 141 ? 2.537   9.794   3.306   1.000 8.035  0 141 PHE   C CE1   1 ? 
ATOM   1086 C  CE2   . PHE   A 1 141 ? 4.699   9.358   4.115   1.000 7.562  0 141 PHE   C CE2   1 ? 
ATOM   1087 C  CZ    . PHE   A 1 141 ? 3.843   9.464   3.070   1.000 7.808  0 141 PHE   C CZ    1 ? 
ATOM   1088 N  N     . LEU   A 1 142 ? 0.965   9.905   9.893   1.000 8.332  0 142 LEU   C N     1 ? 
ATOM   1089 C  CA    . LEU   A 1 142 ? 1.055   9.701   11.334  1.000 7.841  0 142 LEU   C CA    1 ? 
ATOM   1090 C  C     . LEU   A 1 142 ? 0.110   8.593   11.801  1.000 9.181  0 142 LEU   C C     1 ? 
ATOM   1091 O  O     . LEU   A 1 142 ? 0.516   7.753   12.600  1.000 9.093  0 142 LEU   C O     1 ? 
ATOM   1092 C  CB    . LEU   A 1 142 ? 0.780   11.042  12.039  1.000 8.493  0 142 LEU   C CB    1 ? 
ATOM   1093 C  CG    . LEU   A 1 142 ? 0.912   10.993  13.569  1.000 8.459  0 142 LEU   C CG    1 ? 
ATOM   1094 C  CD1   . LEU   A 1 142 ? 2.263   10.456  14.001  1.000 9.362  0 142 LEU   C CD1   1 ? 
ATOM   1095 C  CD2   . LEU   A 1 142 ? 0.687   12.380  14.110  1.000 9.751  0 142 LEU   C CD2   1 ? 
ATOM   1096 N  N     . LYS   A 1 143 ? -1.086  8.604   11.262  1.000 8.672  0 143 LYS   C N     1 ? 
ATOM   1097 C  CA    . LYS   A 1 143 ? -2.051  7.604   11.653  1.000 9.980  0 143 LYS   C CA    1 ? 
ATOM   1098 C  C     . LYS   A 1 143 ? -1.483  6.233   11.304  1.000 9.490  0 143 LYS   C C     1 ? 
ATOM   1099 O  O     . LYS   A 1 143 ? -1.518  5.289   12.109  1.000 9.973  0 143 LYS   C O     1 ? 
ATOM   1100 C  CB    . LYS   A 1 143 ? -3.385  7.834   10.963  1.000 13.024 0 143 LYS   C CB    1 ? 
ATOM   1101 C  CG    . LYS   A 1 143 ? -4.495  6.869   11.350  1.000 19.141 0 143 LYS   C CG    1 ? 
ATOM   1102 C  CD    . LYS   A 1 143 ? -5.856  7.243   10.802  1.000 26.954 0 143 LYS   C CD    1 ? 
ATOM   1103 C  CE    . LYS   A 1 143 ? -6.966  6.865   11.769  1.000 32.191 0 143 LYS   C CE    1 ? 
ATOM   1104 N  NZ    . LYS   A 1 143 ? -6.961  7.740   12.972  1.000 33.850 0 143 LYS   C NZ    1 ? 
ATOM   1105 N  N     . THR   A 1 144 ? -0.946  6.105   10.076  1.000 8.397  0 144 THR   C N     1 ? 
ATOM   1106 C  CA    . THR   A 1 144 ? -0.375  4.832   9.664   1.000 7.697  0 144 THR   C CA    1 ? 
ATOM   1107 C  C     . THR   A 1 144 ? 0.807   4.470   10.568  1.000 7.766  0 144 THR   C C     1 ? 
ATOM   1108 O  O     . THR   A 1 144 ? 0.978   3.309   10.985  1.000 8.311  0 144 THR   C O     1 ? 
ATOM   1109 C  CB    . THR   A 1 144 ? 0.075   4.902   8.214   1.000 8.581  0 144 THR   C CB    1 ? 
ATOM   1110 O  OG1   . THR   A 1 144 ? -1.081  5.053   7.408   1.000 9.505  0 144 THR   C OG1   1 ? 
ATOM   1111 C  CG2   . THR   A 1 144 ? 0.821   3.676   7.788   1.000 8.821  0 144 THR   C CG2   1 ? 
ATOM   1112 N  N     . ALA   A 1 145 ? 1.693   5.439   10.809  1.000 6.935  0 145 ALA   C N     1 ? 
ATOM   1113 C  CA    . ALA   A 1 145 ? 2.897   5.174   11.591  1.000 7.063  0 145 ALA   C CA    1 ? 
ATOM   1114 C  C     . ALA   A 1 145 ? 2.550   4.637   12.976  1.000 7.360  0 145 ALA   C C     1 ? 
ATOM   1115 O  O     . ALA   A 1 145 ? 3.225   3.702   13.462  1.000 7.404  0 145 ALA   C O     1 ? 
ATOM   1116 C  CB    . ALA   A 1 145 ? 3.711   6.434   11.708  1.000 7.479  0 145 ALA   C CB    1 ? 
ATOM   1117 N  N     . LEU   A 1 146 ? 1.571   5.221   13.625  1.000 7.995  0 146 LEU   C N     1 ? 
ATOM   1118 C  CA    . LEU   A 1 146 ? 1.203   4.810   14.969  1.000 7.693  0 146 LEU   C CA    1 ? 
ATOM   1119 C  C     . LEU   A 1 146 ? 0.609   3.402   14.961  1.000 8.832  0 146 LEU   C C     1 ? 
ATOM   1120 O  O     . LEU   A 1 146 ? 0.819   2.685   15.943  1.000 9.790  0 146 LEU   C O     1 ? 
ATOM   1121 C  CB    . LEU   A 1 146 ? 0.183   5.798   15.550  1.000 8.454  0 146 LEU   C CB    1 ? 
ATOM   1122 C  CG    . LEU   A 1 146 ? 0.743   7.177   15.843  1.000 8.633  0 146 LEU   C CG    1 ? 
ATOM   1123 C  CD1   . LEU   A 1 146 ? -0.397  8.143   16.067  1.000 9.590  0 146 LEU   C CD1   1 ? 
ATOM   1124 C  CD2   . LEU   A 1 146 ? 1.691   7.193   17.012  1.000 10.094 0 146 LEU   C CD2   1 ? 
ATOM   1125 N  N     . GLU   A 1 147 ? -0.073  3.036   13.895  1.000 8.635  0 147 GLU   C N     1 ? 
ATOM   1126 C  CA    . GLU   A 1 147 ? -0.617  1.675   13.793  1.000 9.427  0 147 GLU   C CA    1 ? 
ATOM   1127 C  C     . GLU   A 1 147 ? 0.487   0.632   13.597  1.000 8.887  0 147 GLU   C C     1 ? 
ATOM   1128 O  O     . GLU   A 1 147 ? 0.397   -0.520  14.096  1.000 8.662  0 147 GLU   C O     1 ? 
ATOM   1129 C  CB    . GLU   A 1 147 ? -1.657  1.628   12.672  1.000 13.883 0 147 GLU   C CB    1 ? 
ATOM   1130 C  CG    . GLU   A 1 147 ? -2.967  2.321   13.056  1.000 20.120 0 147 GLU   C CG    1 ? 
ATOM   1131 C  CD    . GLU   A 1 147 ? -3.957  2.790   11.990  1.000 32.220 0 147 GLU   C CD    1 ? 
ATOM   1132 O  OE1   . GLU   A 1 147 ? -3.787  2.441   10.793  1.000 41.081 0 147 GLU   C OE1   1 ? 
ATOM   1133 O  OE2   . GLU   A 1 147 ? -4.924  3.541   12.378  1.000 40.082 0 147 GLU   C OE2   1 ? 
ATOM   1134 N  N     . MET   A 1 148 ? 1.567   1.029   12.897  1.000 7.510  0 148 MET   C N     1 ? 
ATOM   1135 C  CA    . MET   A 1 148 ? 2.661   0.140   12.542  1.000 7.116  0 148 MET   C CA    1 ? 
ATOM   1136 C  C     . MET   A 1 148 ? 3.663   -0.013  13.670  1.000 7.441  0 148 MET   C C     1 ? 
ATOM   1137 O  O     . MET   A 1 148 ? 4.330   -1.051  13.754  1.000 7.051  0 148 MET   C O     1 ? 
ATOM   1138 C  CB    . MET   A 1 148 ? 3.383   0.640   11.290  1.000 7.191  0 148 MET   C CB    1 ? 
ATOM   1139 C  CG    . MET   A 1 148 ? 2.600   0.492   10.023  1.000 7.176  0 148 MET   C CG    1 ? 
ATOM   1140 S  SD    . MET   A 1 148 ? 3.325   1.179   8.558   1.000 9.164  0 148 MET   C SD    1 ? 
ATOM   1141 C  CE    . MET   A 1 148 ? 4.789   0.167   8.368   1.000 9.019  0 148 MET   C CE    1 ? 
ATOM   1142 N  N     . ALA   A 1 149 ? 3.843   1.026   14.477  1.000 7.522  0 149 ALA   C N     1 ? 
ATOM   1143 C  CA    . ALA   A 1 149 ? 4.915   1.052   15.458  1.000 7.761  0 149 ALA   C CA    1 ? 
ATOM   1144 C  C     . ALA   A 1 149 ? 4.487   0.525   16.819  1.000 8.325  0 149 ALA   C C     1 ? 
ATOM   1145 O  O     . ALA   A 1 149 ? 3.436   0.905   17.335  1.000 9.280  0 149 ALA   C O     1 ? 
ATOM   1146 C  CB    . ALA   A 1 149 ? 5.358   2.464   15.661  1.000 8.095  0 149 ALA   C CB    1 ? 
ATOM   1147 N  N     . ARG   A 1 150 ? 5.364   -0.264  17.404  1.000 8.037  0 150 ARG   C N     1 ? 
ATOM   1148 C  CA    . ARG   A 1 150 ? 5.164   -0.778  18.759  1.000 9.671  0 150 ARG   C CA    1 ? 
ATOM   1149 C  C     . ARG   A 1 150 ? 5.602   0.212   19.829  1.000 9.194  0 150 ARG   C C     1 ? 
ATOM   1150 O  O     . ARG   A 1 150 ? 4.911   0.319   20.880  1.000 9.789  0 150 ARG   C O     1 ? 
ATOM   1151 C  CB    . ARG   A 1 150 ? 5.919   -2.081  18.978  1.000 9.896  0 150 ARG   C CB    1 ? 
ATOM   1152 C  CG    . ARG   A 1 150 ? 5.316   -3.241  18.208  1.000 10.921 0 150 ARG   C CG    1 ? 
ATOM   1153 C  CD    . ARG   A 1 150 ? 5.930   -4.603  18.479  1.000 11.899 0 150 ARG   C CD    1 ? 
ATOM   1154 N  NE    . ARG   A 1 150 ? 7.279   -4.654  17.968  1.000 13.597 0 150 ARG   C NE    1 ? 
ATOM   1155 C  CZ    . ARG   A 1 150 ? 7.656   -5.297  16.855  1.000 15.721 0 150 ARG   C CZ    1 ? 
ATOM   1156 N  NH1   . ARG   A 1 150 ? 6.738   -5.861  16.084  1.000 15.482 0 150 ARG   C NH1   1 ? 
ATOM   1157 N  NH2   . ARG   A 1 150 ? 8.940   -5.421  16.558  1.000 14.713 0 150 ARG   C NH2   1 ? 
ATOM   1158 N  N     . THR   A 1 151 ? 6.727   0.883   19.609  1.000 8.927  0 151 THR   C N     1 ? 
ATOM   1159 C  CA    . THR   A 1 151 ? 7.422   1.618   20.670  1.000 8.864  0 151 THR   C CA    1 ? 
ATOM   1160 C  C     . THR   A 1 151 ? 7.395   3.123   20.414  1.000 9.144  0 151 THR   C C     1 ? 
ATOM   1161 O  O     . THR   A 1 151 ? 7.070   3.888   21.301  1.000 11.093 0 151 THR   C O     1 ? 
ATOM   1162 C  CB    . THR   A 1 151 ? 8.827   1.058   20.906  1.000 9.739  0 151 THR   C CB    1 ? 
ATOM   1163 O  OG1   . THR   A 1 151 ? 8.695   -0.310  21.328  1.000 12.311 0 151 THR   C OG1   1 ? 
ATOM   1164 C  CG2   . THR   A 1 151 ? 9.617   1.855   21.920  1.000 10.769 0 151 THR   C CG2   1 ? 
ATOM   1165 N  N     . ALA   A 1 152 ? 7.806   3.550   19.210  1.000 8.331  0 152 ALA   C N     1 ? 
ATOM   1166 C  CA    . ALA   A 1 152 ? 7.946   4.989   18.995  1.000 8.673  0 152 ALA   C CA    1 ? 
ATOM   1167 C  C     . ALA   A 1 152 ? 7.833   5.355   17.521  1.000 8.733  0 152 ALA   C C     1 ? 
ATOM   1168 O  O     . ALA   A 1 152 ? 8.240   4.595   16.676  1.000 8.765  0 152 ALA   C O     1 ? 
ATOM   1169 C  CB    . ALA   A 1 152 ? 9.258   5.490   19.554  1.000 9.813  0 152 ALA   C CB    1 ? 
ATOM   1170 N  N     . VAL   A 1 153 ? 7.326   6.568   17.279  1.000 7.672  0 153 VAL   C N     1 ? 
ATOM   1171 C  CA    . VAL   A 1 153 ? 7.297   7.238   15.983  1.000 7.701  0 153 VAL   C CA    1 ? 
ATOM   1172 C  C     . VAL   A 1 153 ? 8.045   8.548   16.107  1.000 7.942  0 153 VAL   C C     1 ? 
ATOM   1173 O  O     . VAL   A 1 153 ? 7.791   9.348   17.031  1.000 9.013  0 153 VAL   C O     1 ? 
ATOM   1174 C  CB    . VAL   A 1 153 ? 5.860   7.507   15.486  1.000 7.939  0 153 VAL   C CB    1 ? 
ATOM   1175 C  CG1   . VAL   A 1 153 ? 5.847   8.196   14.147  1.000 9.188  0 153 VAL   C CG1   1 ? 
ATOM   1176 C  CG2   . VAL   A 1 153 ? 5.060   6.205   15.437  1.000 8.124  0 153 VAL   C CG2   1 ? 
ATOM   1177 N  N     . TYR   A 1 154 ? 8.951   8.804   15.177  1.000 7.356  0 154 TYR   C N     1 ? 
ATOM   1178 C  CA    . TYR   A 1 154 ? 9.660   10.085  15.077  1.000 7.387  0 154 TYR   C CA    1 ? 
ATOM   1179 C  C     . TYR   A 1 154 ? 9.309   10.725  13.743  1.000 7.763  0 154 TYR   C C     1 ? 
ATOM   1180 O  O     . TYR   A 1 154 ? 9.501   10.114  12.695  1.000 7.868  0 154 TYR   C O     1 ? 
ATOM   1181 C  CB    . TYR   A 1 154 ? 11.162  9.872   15.152  1.000 7.999  0 154 TYR   C CB    1 ? 
ATOM   1182 C  CG    . TYR   A 1 154 ? 11.616  9.286   16.456  1.000 7.801  0 154 TYR   C CG    1 ? 
ATOM   1183 C  CD1   . TYR   A 1 154 ? 11.633  7.907   16.658  1.000 7.345  0 154 TYR   C CD1   1 ? 
ATOM   1184 C  CD2   . TYR   A 1 154 ? 12.009  10.104  17.494  1.000 9.564  0 154 TYR   C CD2   1 ? 
ATOM   1185 C  CE1   . TYR   A 1 154 ? 12.072  7.367   17.854  1.000 9.066  0 154 TYR   C CE1   1 ? 
ATOM   1186 C  CE2   . TYR   A 1 154 ? 12.406  9.574   18.697  1.000 10.296 0 154 TYR   C CE2   1 ? 
ATOM   1187 C  CZ    . TYR   A 1 154 ? 12.451  8.207   18.873  1.000 9.548  0 154 TYR   C CZ    1 ? 
ATOM   1188 O  OH    . TYR   A 1 154 ? 12.907  7.662   20.055  1.000 11.353 0 154 TYR   C OH    1 ? 
ATOM   1189 N  N     . SER   A 1 155 ? 8.878   12.002  13.759  1.000 8.361  0 155 SER   C N     1 ? 
ATOM   1190 C  CA    . SER   A 1 155 ? 8.393   12.650  12.556  1.000 7.866  0 155 SER   C CA    1 ? 
ATOM   1191 C  C     . SER   A 1 155 ? 8.588   14.156  12.628  1.000 8.468  0 155 SER   C C     1 ? 
ATOM   1192 O  O     . SER   A 1 155 ? 8.815   14.725  13.682  1.000 10.832 0 155 SER   C O     1 ? 
ATOM   1193 C  CB    . SER   A 1 155 ? 6.918   12.347  12.392  1.000 8.610  0 155 SER   C CB    1 ? 
ATOM   1194 O  OG    . SER   A 1 155 ? 6.364   12.831  11.160  1.000 10.042 0 155 SER   C OG    1 ? 
ATOM   1195 N  N     . LEU   A 1 156 ? 8.600   14.739  11.449  1.000 8.012  0 156 LEU   C N     1 ? 
ATOM   1196 C  CA    . LEU   A 1 156 ? 8.772   16.189  11.276  1.000 7.971  0 156 LEU   C CA    1 ? 
ATOM   1197 C  C     . LEU   A 1 156 ? 7.428   16.745  10.823  1.000 9.033  0 156 LEU   C C     1 ? 
ATOM   1198 O  O     . LEU   A 1 156 ? 6.940   16.365  9.747   1.000 9.435  0 156 LEU   C O     1 ? 
ATOM   1199 C  CB    . LEU   A 1 156 ? 9.904   16.414  10.254  1.000 9.869  0 156 LEU   C CB    1 ? 
ATOM   1200 C  CG    . LEU   A 1 156 ? 11.282  15.917  10.699  1.000 10.166 0 156 LEU   C CG    1 ? 
ATOM   1201 C  CD1   . LEU   A 1 156 ? 12.268  15.852  9.530   1.000 10.701 0 156 LEU   C CD1   1 ? 
ATOM   1202 C  CD2   . LEU   A 1 156 ? 11.871  16.837  11.752  1.000 11.316 0 156 LEU   C CD2   1 ? 
ATOM   1203 N  N     . HIS   A 1 157 ? 6.883   17.711  11.593  1.000 9.432  0 157 HIS   C N     1 ? 
ATOM   1204 C  CA    . HIS   A 1 157 ? 5.630   18.373  11.291  1.000 9.948  0 157 HIS   C CA    1 ? 
ATOM   1205 C  C     . HIS   A 1 157 ? 5.874   19.880  11.286  1.000 10.000 0 157 HIS   C C     1 ? 
ATOM   1206 O  O     . HIS   A 1 157 ? 6.713   20.351  12.022  1.000 12.157 0 157 HIS   C O     1 ? 
ATOM   1207 C  CB    . HIS   A 1 157 ? 4.505   17.964  12.276  1.000 10.007 0 157 HIS   C CB    1 ? 
ATOM   1208 C  CG    . HIS   A 1 157 ? 4.202   16.512  12.181  1.000 9.335  0 157 HIS   C CG    1 ? 
ATOM   1209 N  ND1   . HIS   A 1 157 ? 4.821   15.459  12.803  1.000 11.587 0 157 HIS   C ND1   1 ? 
ATOM   1210 C  CD2   . HIS   A 1 157 ? 3.304   15.994  11.375  1.000 8.065  0 157 HIS   C CD2   1 ? 
ATOM   1211 C  CE1   . HIS   A 1 157 ? 4.295   14.314  12.351  1.000 8.212  0 157 HIS   C CE1   1 ? 
ATOM   1212 N  NE2   . HIS   A 1 157 ? 3.350   14.601  11.465  1.000 11.044 0 157 HIS   C NE2   1 ? 
ATOM   1213 N  N     . LYS   A 1 158 ? 5.084   20.597  10.487  1.000 10.613 0 158 LYS   C N     1 ? 
ATOM   1214 C  CA    . LYS   A 1 158 ? 5.229   22.063  10.513  1.000 11.484 0 158 LYS   C CA    1 ? 
ATOM   1215 C  C     . LYS   A 1 158 ? 5.002   22.569  11.938  1.000 11.982 0 158 LYS   C C     1 ? 
ATOM   1216 O  O     . LYS   A 1 158 ? 3.986   22.231  12.558  1.000 12.490 0 158 LYS   C O     1 ? 
ATOM   1217 C  CB    . LYS   A 1 158 ? 4.245   22.688  9.522   1.000 14.315 0 158 LYS   C CB    1 ? 
ATOM   1218 C  CG    . LYS   A 1 158 ? 4.450   22.337  8.058   1.000 18.222 0 158 LYS   C CG    1 ? 
ATOM   1219 C  CD    . LYS   A 1 158 ? 3.700   23.177  7.041   1.000 23.721 0 158 LYS   C CD    1 ? 
ATOM   1220 C  CE    . LYS   A 1 158 ? 2.199   23.057  7.114   1.000 27.247 0 158 LYS   C CE    1 ? 
ATOM   1221 N  NZ    . LYS   A 1 158 ? 1.570   23.642  5.900   1.000 30.451 0 158 LYS   C NZ    1 ? 
ATOM   1222 N  N     . SER   A 1 159 ? 5.839   23.499  12.406  1.000 11.984 0 159 SER   C N     1 ? 
ATOM   1223 C  CA    . SER   A 1 159 ? 5.687   24.051  13.737  1.000 12.417 0 159 SER   C CA    1 ? 
ATOM   1224 C  C     . SER   A 1 159 ? 4.380   24.852  13.846  1.000 14.539 0 159 SER   C C     1 ? 
ATOM   1225 O  O     . SER   A 1 159 ? 3.801   24.886  14.918  1.000 15.613 0 159 SER   C O     1 ? 
ATOM   1226 C  CB    . SER   A 1 159 ? 6.861   24.944  14.036  1.000 13.862 0 159 SER   C CB    1 ? 
ATOM   1227 O  OG    . SER   A 1 159 ? 8.078   24.217  14.086  1.000 14.603 0 159 SER   C OG    1 ? 
ATOM   1228 N  N     . SER   A 1 160 ? 3.882   25.350  12.708  1.000 15.866 0 160 SER   C N     1 ? 
ATOM   1229 C  CA    . SER   A 1 160 ? 2.632   26.094  12.628  1.000 17.841 0 160 SER   C CA    1 ? 
ATOM   1230 C  C     . SER   A 1 160 ? 1.416   25.219  12.895  1.000 16.779 0 160 SER   C C     1 ? 
ATOM   1231 O  O     . SER   A 1 160 ? 0.320   25.736  13.165  1.000 19.182 0 160 SER   C O     1 ? 
ATOM   1232 C  CB    . SER   A 1 160 ? 2.495   26.801  11.291  1.000 19.246 0 160 SER   C CB    1 ? 
ATOM   1233 O  OG    . SER   A 1 160 ? 2.272   25.886  10.224  1.000 21.396 0 160 SER   C OG    1 ? 
ATOM   1234 N  N     . THR   A 1 161 ? 1.576   23.892  12.837  1.000 14.713 0 161 THR   C N     1 ? 
ATOM   1235 C  CA    . THR   A 1 161 ? 0.477   22.966  13.060  1.000 15.545 0 161 THR   C CA    1 ? 
ATOM   1236 C  C     . THR   A 1 161 ? 0.559   22.298  14.439  1.000 13.739 0 161 THR   C C     1 ? 
ATOM   1237 O  O     . THR   A 1 161 ? -0.204  21.370  14.710  1.000 15.167 0 161 THR   C O     1 ? 
ATOM   1238 C  CB    . THR   A 1 161 ? 0.421   21.882  11.969  1.000 15.731 0 161 THR   C CB    1 ? 
ATOM   1239 O  OG1   . THR   A 1 161 ? 1.544   20.987  12.058  1.000 15.075 0 161 THR   C OG1   1 ? 
ATOM   1240 C  CG2   . THR   A 1 161 ? 0.300   22.492  10.590  1.000 16.969 0 161 THR   C CG2   1 ? 
ATOM   1241 N  N     . ARG   A 1 162 ? 1.460   22.757  15.292  1.000 14.182 0 162 ARG   C N     1 ? 
ATOM   1242 C  CA    . ARG   A 1 162 ? 1.785   22.098  16.559  1.000 13.128 0 162 ARG   C CA    1 ? 
ATOM   1243 C  C     . ARG   A 1 162 ? 0.533   21.817  17.404  1.000 13.915 0 162 ARG   C C     1 ? 
ATOM   1244 O  O     . ARG   A 1 162 ? 0.306   20.707  17.895  1.000 13.592 0 162 ARG   C O     1 ? 
ATOM   1245 C  CB    . ARG   A 1 162 ? 2.827   22.896  17.350  1.000 13.452 0 162 ARG   C CB    1 ? 
ATOM   1246 C  CG    . ARG   A 1 162 ? 3.225   22.254  18.666  1.000 14.684 0 162 ARG   C CG    1 ? 
ATOM   1247 C  CD    . ARG   A 1 162 ? 4.173   23.037  19.531  1.000 14.982 0 162 ARG   C CD    1 ? 
ATOM   1248 N  NE    . ARG   A 1 162 ? 5.436   23.264  18.833  1.000 15.826 0 162 ARG   C NE    1 ? 
ATOM   1249 C  CZ    . ARG   A 1 162 ? 6.444   23.973  19.299  1.000 16.169 0 162 ARG   C CZ    1 ? 
ATOM   1250 N  NH1   . ARG   A 1 162 ? 6.335   24.628  20.438  1.000 15.778 0 162 ARG   C NH1   1 ? 
ATOM   1251 N  NH2   . ARG   A 1 162 ? 7.579   24.086  18.626  1.000 16.600 0 162 ARG   C NH2   1 ? 
ATOM   1252 N  N     . GLU   A 1 163 ? -0.304  22.836  17.574  1.000 16.398 0 163 GLU   C N     1 ? 
ATOM   1253 C  CA    . GLU   A 1 163 ? -1.461  22.672  18.433  1.000 16.588 0 163 GLU   C CA    1 ? 
ATOM   1254 C  C     . GLU   A 1 163 ? -2.366  21.588  17.885  1.000 15.261 0 163 GLU   C C     1 ? 
ATOM   1255 O  O     . GLU   A 1 163 ? -2.966  20.870  18.675  1.000 15.152 0 163 GLU   C O     1 ? 
ATOM   1256 C  CB    . GLU   A 1 163 ? -2.278  23.958  18.494  1.000 20.574 0 163 GLU   C CB    1 ? 
ATOM   1257 C  CG    . GLU   A 1 163 ? -1.687  25.013  19.391  1.000 26.979 0 163 GLU   C CG    1 ? 
ATOM   1258 C  CD    . GLU   A 1 163 ? -2.669  26.138  19.712  1.000 28.457 0 163 GLU   C CD    1 ? 
ATOM   1259 O  OE1   . GLU   A 1 163 ? -3.654  26.310  18.969  1.000 37.219 0 163 GLU   C OE1   1 ? 
ATOM   1260 O  OE2   . GLU   A 1 163 ? -2.477  26.789  20.719  1.000 32.758 0 163 GLU   C OE2   1 ? 
ATOM   1261 N  N     . HIS   A 1 164 ? -2.529  21.518  16.559  1.000 14.522 0 164 HIS   C N     1 ? 
ATOM   1262 C  CA    . HIS   A 1 164 ? -3.380  20.507  15.954  1.000 13.114 0 164 HIS   C CA    1 ? 
ATOM   1263 C  C     . HIS   A 1 164 ? -2.807  19.118  16.239  1.000 12.363 0 164 HIS   C C     1 ? 
ATOM   1264 O  O     . HIS   A 1 164 ? -3.534  18.160  16.569  1.000 12.511 0 164 HIS   C O     1 ? 
ATOM   1265 C  CB    . HIS   A 1 164 ? -3.560  20.693  14.445  1.000 14.932 0 164 HIS   C CB    1 ? 
ATOM   1266 C  CG    . HIS   A 1 164 ? -4.379  19.633  13.786  1.000 17.003 0 164 HIS   C CG    1 ? 
ATOM   1267 N  ND1   . HIS   A 1 164 ? -5.737  19.533  13.984  1.000 19.464 0 164 HIS   C ND1   1 ? 
ATOM   1268 C  CD2   . HIS   A 1 164 ? -4.055  18.598  12.996  1.000 18.961 0 164 HIS   C CD2   1 ? 
ATOM   1269 C  CE1   . HIS   A 1 164 ? -6.205  18.485  13.308  1.000 17.274 0 164 HIS   C CE1   1 ? 
ATOM   1270 N  NE2   . HIS   A 1 164 ? -5.199  17.869  12.704  1.000 19.439 0 164 HIS   C NE2   1 ? 
ATOM   1271 N  N     . VAL   A 1 165 ? -1.497  18.968  16.053  1.000 12.067 0 165 VAL   C N     1 ? 
ATOM   1272 C  CA    . VAL   A 1 165 ? -0.872  17.677  16.313  1.000 11.512 0 165 VAL   C CA    1 ? 
ATOM   1273 C  C     . VAL   A 1 165 ? -1.085  17.277  17.777  1.000 12.021 0 165 VAL   C C     1 ? 
ATOM   1274 O  O     . VAL   A 1 165 ? -1.358  16.105  18.064  1.000 11.448 0 165 VAL   C O     1 ? 
ATOM   1275 C  CB    . VAL   A 1 165 ? 0.617   17.716  15.905  1.000 12.261 0 165 VAL   C CB    1 ? 
ATOM   1276 C  CG1   . VAL   A 1 165 ? 1.291   16.377  16.168  1.000 13.108 0 165 VAL   C CG1   1 ? 
ATOM   1277 C  CG2   . VAL   A 1 165 ? 0.836   18.107  14.456  1.000 12.654 0 165 VAL   C CG2   1 ? 
ATOM   1278 N  N     . GLN   A 1 166 ? -0.887  18.227  18.698  1.000 11.866 0 166 GLN   C N     1 ? 
ATOM   1279 C  CA    . GLN   A 1 166 ? -1.066  17.981  20.129  1.000 12.605 0 166 GLN   C CA    1 ? 
ATOM   1280 C  C     . GLN   A 1 166 ? -2.505  17.531  20.440  1.000 13.214 0 166 GLN   C C     1 ? 
ATOM   1281 O  O     . GLN   A 1 166 ? -2.736  16.592  21.213  1.000 14.478 0 166 GLN   C O     1 ? 
ATOM   1282 C  CB    . GLN   A 1 166 ? -0.662  19.220  20.932  1.000 13.864 0 166 GLN   C CB    1 ? 
ATOM   1283 C  CG    . GLN   A 1 166 ? 0.834   19.483  21.016  1.000 13.292 0 166 GLN   C CG    1 ? 
ATOM   1284 C  CD    . GLN   A 1 166 ? 1.177   20.849  21.558  1.000 14.062 0 166 GLN   C CD    1 ? 
ATOM   1285 O  OE1   . GLN   A 1 166 ? 0.484   21.826  21.299  1.000 16.388 0 166 GLN   C OE1   1 ? 
ATOM   1286 N  NE2   . GLN   A 1 166 ? 2.295   20.939  22.255  1.000 16.624 0 166 GLN   C NE2   1 ? 
ATOM   1287 N  N     . LYS   A 1 167 ? -3.473  18.148  19.762  1.000 13.105 0 167 LYS   C N     1 ? 
ATOM   1288 C  CA    . LYS   A 1 167 ? -4.877  17.812  19.969  1.000 14.094 0 167 LYS   C CA    1 ? 
ATOM   1289 C  C     . LYS   A 1 167 ? -5.176  16.402  19.479  1.000 14.906 0 167 LYS   C C     1 ? 
ATOM   1290 O  O     . LYS   A 1 167 ? -5.855  15.624  20.151  1.000 15.347 0 167 LYS   C O     1 ? 
ATOM   1291 C  CB    . LYS   A 1 167 ? -5.725  18.827  19.219  1.000 16.267 0 167 LYS   C CB    1 ? 
ATOM   1292 C  CG    . LYS   A 1 167 ? -7.219  18.605  19.308  1.000 20.769 0 167 LYS   C CG    1 ? 
ATOM   1293 C  CD    . LYS   A 1 167 ? -7.976  19.510  18.395  1.000 24.555 0 167 LYS   C CD    1 ? 
ATOM   1294 C  CE    . LYS   A 1 167 ? -9.398  19.015  18.214  1.000 30.587 0 167 LYS   C CE    1 ? 
ATOM   1295 N  NZ    . LYS   A 1 167 ? -10.261 20.038  17.593  1.000 34.911 0 167 LYS   C NZ    1 ? 
ATOM   1296 N  N     . LYS   A 1 168 ? -4.670  16.042  18.298  1.000 13.610 0 168 LYS   C N     1 ? 
ATOM   1297 C  CA    . LYS   A 1 168 ? -4.895  14.688  17.820  1.000 13.482 0 168 LYS   C CA    1 ? 
ATOM   1298 C  C     . LYS   A 1 168 ? -4.218  13.624  18.676  1.000 14.628 0 168 LYS   C C     1 ? 
ATOM   1299 O  O     . LYS   A 1 168 ? -4.816  12.579  18.960  1.000 14.283 0 168 LYS   C O     1 ? 
ATOM   1300 C  CB    . LYS   A 1 168 ? -4.484  14.536  16.354  1.000 15.110 0 168 LYS   C CB    1 ? 
ATOM   1301 C  CG    . LYS   A 1 168 ? -5.282  15.341  15.337  1.000 16.828 0 168 LYS   C CG    1 ? 
ATOM   1302 C  CD    . LYS   A 1 168 ? -6.774  15.230  15.408  1.000 17.666 0 168 LYS   C CD    1 ? 
ATOM   1303 C  CE    . LYS   A 1 168 ? -7.302  13.843  15.103  1.000 18.887 0 168 LYS   C CE    1 ? 
ATOM   1304 N  NZ    . LYS   A 1 168 ? -8.786  13.814  15.128  1.000 20.033 0 168 LYS   C NZ    1 ? 
ATOM   1305 N  N     . ALA   A 1 169 ? -3.024  13.917  19.191  1.000 13.585 0 169 ALA   C N     1 ? 
ATOM   1306 C  CA    . ALA   A 1 169 ? -2.341  12.970  20.061  1.000 12.976 0 169 ALA   C CA    1 ? 
ATOM   1307 C  C     . ALA   A 1 169 ? -3.177  12.727  21.320  1.000 13.392 0 169 ALA   C C     1 ? 
ATOM   1308 O  O     . ALA   A 1 169 ? -3.292  11.582  21.759  1.000 13.989 0 169 ALA   C O     1 ? 
ATOM   1309 C  CB    . ALA   A 1 169 ? -0.933  13.419  20.388  1.000 12.753 0 169 ALA   C CB    1 ? 
ATOM   1310 N  N     . ALA   A 1 170 ? -3.769  13.785  21.851  1.000 14.074 0 170 ALA   C N     1 ? 
ATOM   1311 C  CA    . ALA   A 1 170 ? -4.592  13.645  23.054  1.000 15.466 0 170 ALA   C CA    1 ? 
ATOM   1312 C  C     . ALA   A 1 170 ? -5.830  12.811  22.760  1.000 16.126 0 170 ALA   C C     1 ? 
ATOM   1313 O  O     . ALA   A 1 170 ? -6.157  11.934  23.559  1.000 18.345 0 170 ALA   C O     1 ? 
ATOM   1314 C  CB    . ALA   A 1 170 ? -4.951  15.000  23.627  1.000 15.823 0 170 ALA   C CB    1 ? 
ATOM   1315 N  N     . GLU   A 1 171 ? -6.508  13.064  21.639  1.000 14.926 0 171 GLU   C N     1 ? 
ATOM   1316 C  CA    . GLU   A 1 171 ? -7.665  12.294  21.212  1.000 15.359 0 171 GLU   C CA    1 ? 
ATOM   1317 C  C     . GLU   A 1 171 ? -7.308  10.813  21.070  1.000 15.264 0 171 GLU   C C     1 ? 
ATOM   1318 O  O     . GLU   A 1 171 ? -8.150  9.958   21.349  1.000 16.500 0 171 GLU   C O     1 ? 
ATOM   1319 C  CB    . GLU   A 1 171 ? -8.238  12.800  19.884  1.000 15.609 0 171 GLU   C CB    1 ? 
ATOM   1320 C  CG    . GLU   A 1 171 ? -8.845  14.180  20.016  1.000 18.090 0 171 GLU   C CG    1 ? 
ATOM   1321 C  CD    . GLU   A 1 171 ? -9.383  14.798  18.756  1.000 23.204 0 171 GLU   C CD    1 ? 
ATOM   1322 O  OE1   . GLU   A 1 171 ? -9.312  14.157  17.681  1.000 25.010 0 171 GLU   C OE1   1 ? 
ATOM   1323 O  OE2   . GLU   A 1 171 ? -9.850  15.954  18.857  1.000 29.142 0 171 GLU   C OE2   1 ? 
ATOM   1324 N  N     . TRP   A 1 172 ? -6.100  10.535  20.544  1.000 14.408 0 172 TRP   C N     1 ? 
ATOM   1325 C  CA    . TRP   A 1 172 ? -5.639  9.170   20.283  1.000 16.173 0 172 TRP   C CA    1 ? 
ATOM   1326 C  C     . TRP   A 1 172 ? -5.028  8.483   21.515  1.000 15.885 0 172 TRP   C C     1 ? 
ATOM   1327 O  O     . TRP   A 1 172 ? -4.645  7.316   21.421  1.000 17.975 0 172 TRP   C O     1 ? 
ATOM   1328 C  CB    . TRP   A 1 172 ? -4.631  9.206   19.111  1.000 15.206 0 172 TRP   C CB    1 ? 
ATOM   1329 C  CG    . TRP   A 1 172 ? -5.229  9.658   17.823  1.000 15.902 0 172 TRP   C CG    1 ? 
ATOM   1330 C  CD1   . TRP   A 1 172 ? -6.547  9.680   17.494  1.000 18.600 0 172 TRP   C CD1   1 ? 
ATOM   1331 C  CD2   . TRP   A 1 172 ? -4.533  10.149  16.665  1.000 17.609 0 172 TRP   C CD2   1 ? 
ATOM   1332 N  NE1   . TRP   A 1 172 ? -6.720  10.145  16.218  1.000 18.598 0 172 TRP   C NE1   1 ? 
ATOM   1333 C  CE2   . TRP   A 1 172 ? -5.500  10.453  15.687  1.000 18.419 0 172 TRP   C CE2   1 ? 
ATOM   1334 C  CE3   . TRP   A 1 172 ? -3.189  10.374  16.359  1.000 17.164 0 172 TRP   C CE3   1 ? 
ATOM   1335 C  CZ2   . TRP   A 1 172 ? -5.176  10.923  14.417  1.000 20.538 0 172 TRP   C CZ2   1 ? 
ATOM   1336 C  CZ3   . TRP   A 1 172 ? -2.870  10.861  15.100  1.000 19.162 0 172 TRP   C CZ3   1 ? 
ATOM   1337 C  CH2   . TRP   A 1 172 ? -3.846  11.139  14.151  1.000 21.103 0 172 TRP   C CH2   1 ? 
ATOM   1338 N  N     . LYS   A 1 173 ? -4.882  9.191   22.628  1.000 15.841 0 173 LYS   C N     1 ? 
ATOM   1339 C  CA    . LYS   A 1 173 ? -4.212  8.719   23.827  1.000 18.367 0 173 LYS   C CA    1 ? 
ATOM   1340 C  C     . LYS   A 1 173 ? -2.781  8.291   23.526  1.000 18.081 0 173 LYS   C C     1 ? 
ATOM   1341 O  O     . LYS   A 1 173 ? -2.323  7.240   24.011  1.000 21.289 0 173 LYS   C O     1 ? 
ATOM   1342 C  CB    . LYS   A 1 173 ? -5.055  7.593   24.446  1.000 21.500 0 173 LYS   C CB    1 ? 
ATOM   1343 C  CG    . LYS   A 1 173 ? -6.410  8.068   24.961  1.000 22.544 0 173 LYS   C CG    1 ? 
ATOM   1344 C  CD    . LYS   A 1 173 ? -7.159  7.004   25.778  1.000 22.988 0 173 LYS   C CD    1 ? 
ATOM   1345 C  CE    . LYS   A 1 173 ? -8.458  7.494   26.395  1.000 22.885 0 173 LYS   C CE    1 ? 
ATOM   1346 N  NZ    . LYS   A 1 173 ? -9.399  7.957   25.353  1.000 23.236 0 173 LYS   C NZ    1 ? 
ATOM   1347 N  N     . ILE   A 1 174 ? -2.091  9.124   22.744  1.000 15.579 0 174 ILE   C N     1 ? 
ATOM   1348 C  CA    . ILE   A 1 174 ? -0.676  8.974   22.386  1.000 17.077 0 174 ILE   C CA    1 ? 
ATOM   1349 C  C     . ILE   A 1 174 ? 0.138   9.989   23.162  1.000 15.778 0 174 ILE   C C     1 ? 
ATOM   1350 O  O     . ILE   A 1 174 ? -0.287  11.135  23.249  1.000 18.828 0 174 ILE   C O     1 ? 
ATOM   1351 C  CB    . ILE   A 1 174 ? -0.533  9.223   20.869  1.000 17.719 0 174 ILE   C CB    1 ? 
ATOM   1352 C  CG1   . ILE   A 1 174 ? -1.356  8.190   20.098  1.000 17.812 0 174 ILE   C CG1   1 ? 
ATOM   1353 C  CG2   . ILE   A 1 174 ? 0.922   9.224   20.392  1.000 19.784 0 174 ILE   C CG2   1 ? 
ATOM   1354 C  CD1   . ILE   A 1 174 ? -0.925  6.776   20.367  1.000 18.718 0 174 ILE   C CD1   1 ? 
ATOM   1355 N  N     . LYS   A 1 175 ? 1.275   9.587   23.725  1.000 13.853 0 175 LYS   C N     1 ? 
ATOM   1356 C  CA    . LYS   A 1 175 ? 2.178   10.521  24.347  1.000 15.188 0 175 LYS   C CA    1 ? 
ATOM   1357 C  C     . LYS   A 1 175 ? 2.929   11.256  23.246  1.000 13.147 0 175 LYS   C C     1 ? 
ATOM   1358 O  O     . LYS   A 1 175 ? 3.324   10.655  22.228  1.000 12.829 0 175 LYS   C O     1 ? 
ATOM   1359 C  CB    . LYS   A 1 175 ? 3.142   9.776   25.246  1.000 16.416 0 175 LYS   C CB    1 ? 
ATOM   1360 C  CG    . LYS   A 1 175 ? 2.482   8.967   26.366  1.000 22.291 0 175 LYS   C CG    1 ? 
ATOM   1361 C  CD    . LYS   A 1 175 ? 1.761   9.814   27.399  1.000 29.032 0 175 LYS   C CD    1 ? 
ATOM   1362 C  CE    . LYS   A 1 175 ? 1.410   9.068   28.676  1.000 36.456 0 175 LYS   C CE    1 ? 
ATOM   1363 N  NZ    . LYS   A 1 175 ? 0.237   8.177   28.516  1.000 43.224 0 175 LYS   C NZ    1 ? 
ATOM   1364 N  N     . ILE   A 1 176 ? 3.111   12.564  23.447  1.000 11.350 0 176 ILE   C N     1 ? 
ATOM   1365 C  CA    . ILE   A 1 176 ? 3.720   13.430  22.462  1.000 12.890 0 176 ILE   C CA    1 ? 
ATOM   1366 C  C     . ILE   A 1 176 ? 4.817   14.233  23.144  1.000 13.703 0 176 ILE   C C     1 ? 
ATOM   1367 O  O     . ILE   A 1 176 ? 4.579   14.823  24.203  1.000 16.180 0 176 ILE   C O     1 ? 
ATOM   1368 C  CB    . ILE   A 1 176 ? 2.701   14.289  21.693  1.000 12.781 0 176 ILE   C CB    1 ? 
ATOM   1369 C  CG1   . ILE   A 1 176 ? 3.432   15.214  20.716  1.000 13.337 0 176 ILE   C CG1   1 ? 
ATOM   1370 C  CG2   . ILE   A 1 176 ? 1.776   15.068  22.645  1.000 13.989 0 176 ILE   C CG2   1 ? 
ATOM   1371 C  CD1   . ILE   A 1 176 ? 2.485   15.894  19.764  1.000 13.682 0 176 ILE   C CD1   1 ? 
ATOM   1372 N  N     . ASP   A 1 177 ? 6.008   14.278  22.558  1.000 11.826 0 177 ASP   C N     1 ? 
ATOM   1373 C  CA    . ASP   A 1 177 ? 7.054   15.165  23.054  1.000 13.051 0 177 ASP   C CA    1 ? 
ATOM   1374 C  C     . ASP   A 1 177 ? 7.729   15.871  21.899  1.000 11.277 0 177 ASP   C C     1 ? 
ATOM   1375 O  O     . ASP   A 1 177 ? 8.228   15.243  20.957  1.000 11.670 0 177 ASP   C O     1 ? 
ATOM   1376 C  CB    . ASP   A 1 177 ? 8.132   14.427  23.823  1.000 16.227 0 177 ASP   C CB    1 ? 
ATOM   1377 C  CG    . ASP   A 1 177 ? 8.969   15.330  24.736  1.000 22.097 0 177 ASP   C CG    1 ? 
ATOM   1378 O  OD1   . ASP   A 1 177 ? 8.602   16.517  24.959  1.000 28.695 0 177 ASP   C OD1   1 ? 
ATOM   1379 O  OD2   . ASP   A 1 177 ? 9.983   14.839  25.266  1.000 28.112 0 177 ASP   C OD2   1 ? 
ATOM   1380 N  N     . ILE   A 1 178 ? 7.696   17.200  21.949  1.000 11.396 0 178 ILE   C N     1 ? 
ATOM   1381 C  CA    . ILE   A 1 178 ? 8.363   18.035  20.957  1.000 12.302 0 178 ILE   C CA    1 ? 
ATOM   1382 C  C     . ILE   A 1 178 ? 9.841   18.102  21.311  1.000 11.888 0 178 ILE   C C     1 ? 
ATOM   1383 O  O     . ILE   A 1 178 ? 10.196  18.684  22.355  1.000 12.665 0 178 ILE   C O     1 ? 
ATOM   1384 C  CB    . ILE   A 1 178 ? 7.762   19.450  20.902  1.000 12.737 0 178 ILE   C CB    1 ? 
ATOM   1385 C  CG1   . ILE   A 1 178 ? 6.240   19.504  20.799  1.000 18.487 0 178 ILE   C CG1   1 ? 
ATOM   1386 C  CG2   . ILE   A 1 178 ? 8.447   20.224  19.792  1.000 14.108 0 178 ILE   C CG2   1 ? 
ATOM   1387 C  CD1   . ILE   A 1 178 ? 5.705   18.878  19.601  1.000 18.618 0 178 ILE   C CD1   1 ? 
ATOM   1388 N  N     . ILE   A 1 179 ? 10.745  17.461  20.543  1.000 11.584 0 179 ILE   C N     1 ? 
ATOM   1389 C  CA    . ILE   A 1 179 ? 12.111  17.305  21.009  1.000 13.880 0 179 ILE   C CA    1 ? 
ATOM   1390 C  C     . ILE   A 1 179 ? 13.040  18.341  20.360  1.000 13.835 0 179 ILE   C C     1 ? 
ATOM   1391 O  O     . ILE   A 1 179 ? 14.094  18.616  20.943  1.000 15.954 0 179 ILE   C O     1 ? 
ATOM   1392 C  CB    . ILE   A 1 179 ? 12.526  15.814  21.006  1.000 17.859 0 179 ILE   C CB    1 ? 
ATOM   1393 C  CG1   . ILE   A 1 179 ? 12.438  15.146  19.655  1.000 18.175 0 179 ILE   C CG1   1 ? 
ATOM   1394 C  CG2   . ILE   A 1 179 ? 11.658  15.073  22.015  1.000 20.724 0 179 ILE   C CG2   1 ? 
ATOM   1395 C  CD1   . ILE   A 1 179 ? 12.968  13.694  19.632  1.000 16.757 0 179 ILE   C CD1   1 ? 
ATOM   1396 N  N     . ALA   A 1 180 ? 12.682  18.969  19.233  1.000 12.109 0 180 ALA   C N     1 ? 
ATOM   1397 C  CA    . ALA   A 1 180 ? 13.512  20.021  18.655  1.000 11.651 0 180 ALA   C CA    1 ? 
ATOM   1398 C  C     . ALA   A 1 180 ? 12.670  20.903  17.731  1.000 12.017 0 180 ALA   C C     1 ? 
ATOM   1399 O  O     . ALA   A 1 180 ? 11.727  20.419  17.132  1.000 12.173 0 180 ALA   C O     1 ? 
ATOM   1400 C  CB    . ALA   A 1 180 ? 14.675  19.465  17.861  1.000 13.658 0 180 ALA   C CB    1 ? 
ATOM   1401 N  N     . GLU   A 1 181 ? 13.073  22.179  17.588  1.000 13.886 0 181 GLU   C N     1 ? 
ATOM   1402 C  CA    . GLU   A 1 181 ? 12.560  23.097  16.588  1.000 14.359 0 181 GLU   C CA    1 ? 
ATOM   1403 C  C     . GLU   A 1 181 ? 13.652  23.327  15.565  1.000 15.748 0 181 GLU   C C     1 ? 
ATOM   1404 O  O     . GLU   A 1 181 ? 14.765  23.658  15.945  1.000 17.000 0 181 GLU   C O     1 ? 
ATOM   1405 C  CB    . GLU   A 1 181 ? 12.221  24.432  17.238  1.000 15.609 0 181 GLU   C CB    1 ? 
ATOM   1406 C  CG    . GLU   A 1 181 ? 11.062  24.322  18.181  1.000 17.358 0 181 GLU   C CG    1 ? 
ATOM   1407 C  CD    . GLU   A 1 181 ? 10.815  25.578  18.996  1.000 19.301 0 181 GLU   C CD    1 ? 
ATOM   1408 O  OE1   . GLU   A 1 181 ? 11.784  26.372  19.211  1.000 26.666 0 181 GLU   C OE1   1 ? 
ATOM   1409 O  OE2   . GLU   A 1 181 ? 9.671   25.787  19.384  1.000 18.847 0 181 GLU   C OE2   1 ? 
ATOM   1410 N  N     . LEU   A 1 182 ? 13.347  23.002  14.313  1.000 14.293 0 182 LEU   C N     1 ? 
ATOM   1411 C  CA    . LEU   A 1 182 ? 14.338  22.957  13.251  1.000 15.218 0 182 LEU   C CA    1 ? 
ATOM   1412 C  C     . LEU   A 1 182 ? 13.830  23.780  12.095  1.000 14.789 0 182 LEU   C C     1 ? 
ATOM   1413 O  O     . LEU   A 1 182 ? 12.660  24.147  11.999  1.000 14.276 0 182 LEU   C O     1 ? 
ATOM   1414 C  CB    . LEU   A 1 182 ? 14.507  21.511  12.796  1.000 15.808 0 182 LEU   C CB    1 ? 
ATOM   1415 C  CG    . LEU   A 1 182 ? 14.958  20.523  13.861  1.000 17.538 0 182 LEU   C CG    1 ? 
ATOM   1416 C  CD1   . LEU   A 1 182 ? 14.977  19.094  13.361  1.000 18.884 0 182 LEU   C CD1   1 ? 
ATOM   1417 C  CD2   . LEU   A 1 182 ? 16.306  20.893  14.414  1.000 17.678 0 182 LEU   C CD2   1 ? 
ATOM   1418 N  N     . ARG   A 1 183 ? 14.786  24.118  11.217  1.000 15.588 0 183 ARG   C N     1 ? 
ATOM   1419 C  CA    . ARG   A 1 183 ? 14.490  24.822  9.988   1.000 16.615 0 183 ARG   C CA    1 ? 
ATOM   1420 C  C     . ARG   A 1 183 ? 15.365  24.227  8.892   1.000 13.352 0 183 ARG   C C     1 ? 
ATOM   1421 O  O     . ARG   A 1 183 ? 16.524  23.888  9.113   1.000 15.889 0 183 ARG   C O     1 ? 
ATOM   1422 C  CB    . ARG   A 1 183 ? 14.791  26.311  10.199  1.000 20.457 0 183 ARG   C CB    1 ? 
ATOM   1423 C  CG    . ARG   A 1 183 ? 14.236  27.258  9.153   1.000 29.119 0 183 ARG   C CG    1 ? 
ATOM   1424 C  CD    . ARG   A 1 183 ? 14.142  28.675  9.704   1.000 33.058 0 183 ARG   C CD    1 ? 
ATOM   1425 N  NE    . ARG   A 1 183 ? 15.401  29.075  10.297  1.000 38.805 0 183 ARG   C NE    1 ? 
ATOM   1426 C  CZ    . ARG   A 1 183 ? 15.819  30.333  10.408  1.000 52.108 0 183 ARG   C CZ    1 ? 
ATOM   1427 N  NH1   . ARG   A 1 183 ? 15.103  31.317  9.890   1.000 60.998 0 183 ARG   C NH1   1 ? 
ATOM   1428 N  NH2   . ARG   A 1 183 ? 16.959  30.606  11.025  1.000 48.399 0 183 ARG   C NH2   1 ? 
ATOM   1429 N  N     . TYR   A 1 184 ? 14.779  24.107  7.714   1.000 11.370 0 184 TYR   C N     1 ? 
ATOM   1430 C  CA    . TYR   A 1 184 ? 15.547  23.730  6.539   1.000 11.306 0 184 TYR   C CA    1 ? 
ATOM   1431 C  C     . TYR   A 1 184 ? 14.914  24.269  5.272   1.000 12.127 0 184 TYR   C C     1 ? 
ATOM   1432 O  O     . TYR   A 1 184 ? 13.754  24.605  5.245   1.000 12.214 0 184 TYR   C O     1 ? 
ATOM   1433 C  CB    . TYR   A 1 184 ? 15.669  22.204  6.461   1.000 10.004 0 184 TYR   C CB    1 ? 
ATOM   1434 C  CG    . TYR   A 1 184 ? 14.379  21.403  6.303   1.000 10.436 0 184 TYR   C CG    1 ? 
ATOM   1435 C  CD1   . TYR   A 1 184 ? 13.756  21.246  5.066   1.000 11.372 0 184 TYR   C CD1   1 ? 
ATOM   1436 C  CD2   . TYR   A 1 184 ? 13.752  20.832  7.397   1.000 10.590 0 184 TYR   C CD2   1 ? 
ATOM   1437 C  CE1   . TYR   A 1 184 ? 12.606  20.487  4.909   1.000 11.864 0 184 TYR   C CE1   1 ? 
ATOM   1438 C  CE2   . TYR   A 1 184 ? 12.622  20.048  7.256   1.000 12.153 0 184 TYR   C CE2   1 ? 
ATOM   1439 C  CZ    . TYR   A 1 184 ? 12.047  19.885  6.008   1.000 10.882 0 184 TYR   C CZ    1 ? 
ATOM   1440 O  OH    . TYR   A 1 184 ? 10.919  19.125  5.831   1.000 12.371 0 184 TYR   C OH    1 ? 
ATOM   1441 N  N     . ASP   A 1 185 ? 15.724  24.350  4.220   1.000 13.057 0 185 ASP   C N     1 ? 
ATOM   1442 C  CA    . ASP   A 1 185 ? 15.314  24.917  2.950   1.000 13.197 0 185 ASP   C CA    1 ? 
ATOM   1443 C  C     . ASP   A 1 185 ? 14.473  23.942  2.153   1.000 13.219 0 185 ASP   C C     1 ? 
ATOM   1444 O  O     . ASP   A 1 185 ? 14.765  22.753  2.019   1.000 11.786 0 185 ASP   C O     1 ? 
ATOM   1445 C  CB    . ASP   A 1 185 ? 16.549  25.309  2.144   1.000 14.328 0 185 ASP   C CB    1 ? 
ATOM   1446 C  CG    . ASP   A 1 185 ? 17.301  26.522  2.653   1.000 16.111 0 185 ASP   C CG    1 ? 
ATOM   1447 O  OD1   . ASP   A 1 185 ? 16.787  27.275  3.537   1.000 20.774 0 185 ASP   C OD1   1 ? 
ATOM   1448 O  OD2   . ASP   A 1 185 ? 18.402  26.728  2.109   1.000 21.840 0 185 ASP   C OD2   1 ? 
ATOM   1449 N  N     . LEU   A 1 186 ? 13.381  24.453  1.620   1.000 13.498 0 186 LEU   C N     1 ? 
ATOM   1450 C  CA    . LEU   A 1 186 ? 12.597  23.748  0.614   1.000 13.582 0 186 LEU   C CA    1 ? 
ATOM   1451 C  C     . LEU   A 1 186 ? 13.258  23.983  -0.737  1.000 14.253 0 186 LEU   C C     1 ? 
ATOM   1452 O  O     . LEU   A 1 186 ? 14.003  24.952  -0.922  1.000 15.341 0 186 LEU   C O     1 ? 
ATOM   1453 C  CB    . LEU   A 1 186 ? 11.184  24.330  0.602   1.000 13.960 0 186 LEU   C CB    1 ? 
ATOM   1454 C  CG    . LEU   A 1 186 ? 10.320  24.010  1.818   1.000 13.398 0 186 LEU   C CG    1 ? 
ATOM   1455 C  CD1   . LEU   A 1 186 ? 9.019   24.822  1.820   1.000 14.720 0 186 LEU   C CD1   1 ? 
ATOM   1456 C  CD2   . LEU   A 1 186 ? 10.024  22.530  1.867   1.000 14.919 0 186 LEU   C CD2   1 ? 
ATOM   1457 N  N     . PRO   A 1 187 ? 12.956  23.164  -1.759  1.000 13.445 0 187 PRO   C N     1 ? 
ATOM   1458 C  CA    . PRO   A 1 187 ? 13.467  23.421  -3.100  1.000 14.255 0 187 PRO   C CA    1 ? 
ATOM   1459 C  C     . PRO   A 1 187 ? 13.053  24.807  -3.576  1.000 15.745 0 187 PRO   C C     1 ? 
ATOM   1460 O  O     . PRO   A 1 187 ? 11.988  25.291  -3.241  1.000 15.045 0 187 PRO   C O     1 ? 
ATOM   1461 C  CB    . PRO   A 1 187 ? 12.798  22.333  -3.942  1.000 14.719 0 187 PRO   C CB    1 ? 
ATOM   1462 C  CG    . PRO   A 1 187 ? 12.573  21.218  -2.972  1.000 14.213 0 187 PRO   C CG    1 ? 
ATOM   1463 C  CD    . PRO   A 1 187 ? 12.149  21.923  -1.698  1.000 13.677 0 187 PRO   C CD    1 ? 
ATOM   1464 N  N     . ALA   A 1 188 ? 13.930  25.484  -4.327  1.000 17.167 0 188 ALA   C N     1 ? 
ATOM   1465 C  CA    . ALA   A 1 188 ? 13.700  26.879  -4.696  1.000 19.381 0 188 ALA   C CA    1 ? 
ATOM   1466 C  C     . ALA   A 1 188 ? 12.388  27.047  -5.456  1.000 20.327 0 188 ALA   C C     1 ? 
ATOM   1467 O  O     . ALA   A 1 188 ? 11.749  28.110  -5.426  1.000 22.254 0 188 ALA   C O     1 ? 
ATOM   1468 C  CB    . ALA   A 1 188 ? 14.828  27.361  -5.595  1.000 20.102 0 188 ALA   C CB    1 ? 
ATOM   1469 N  N     . SER   A 1 189 ? 12.080  26.021  -6.241  1.000 19.816 0 189 SER   C N     1 ? 
ATOM   1470 C  CA    . SER   A 1 189 ? 10.888  26.004  -7.066  1.000 23.018 0 189 SER   C CA    1 ? 
ATOM   1471 C  C     . SER   A 1 189 ? 9.602   26.022  -6.237  1.000 20.361 0 189 SER   C C     1 ? 
ATOM   1472 O  O     . SER   A 1 189 ? 8.542   26.309  -6.798  1.000 22.440 0 189 SER   C O     1 ? 
ATOM   1473 C  CB    . SER   A 1 189 ? 10.927  24.844  -8.012  1.000 24.072 0 189 SER   C CB    1 ? 
ATOM   1474 O  OG    . SER   A 1 189 ? 10.815  23.602  -7.332  1.000 27.050 0 189 SER   C OG    1 ? 
ATOM   1475 N  N     . TYR   A 1 190 ? 9.675   25.728  -4.929  1.000 16.628 0 190 TYR   C N     1 ? 
ATOM   1476 C  CA    . TYR   A 1 190 ? 8.496   25.741  -4.078  1.000 15.079 0 190 TYR   C CA    1 ? 
ATOM   1477 C  C     . TYR   A 1 190 ? 8.055   27.171  -3.695  1.000 15.856 0 190 TYR   C C     1 ? 
ATOM   1478 O  O     . TYR   A 1 190 ? 6.970   27.338  -3.150  1.000 17.668 0 190 TYR   C O     1 ? 
ATOM   1479 C  CB    . TYR   A 1 190 ? 8.703   24.939  -2.785  1.000 14.624 0 190 TYR   C CB    1 ? 
ATOM   1480 C  CG    . TYR   A 1 190 ? 8.702   23.432  -2.877  1.000 13.782 0 190 TYR   C CG    1 ? 
ATOM   1481 C  CD1   . TYR   A 1 190 ? 9.083   22.795  -4.042  1.000 13.638 0 190 TYR   C CD1   1 ? 
ATOM   1482 C  CD2   . TYR   A 1 190 ? 8.354   22.693  -1.756  1.000 14.638 0 190 TYR   C CD2   1 ? 
ATOM   1483 C  CE1   . TYR   A 1 190 ? 9.109   21.405  -4.091  1.000 13.570 0 190 TYR   C CE1   1 ? 
ATOM   1484 C  CE2   . TYR   A 1 190 ? 8.405   21.300  -1.777  1.000 13.988 0 190 TYR   C CE2   1 ? 
ATOM   1485 C  CZ    . TYR   A 1 190 ? 8.814   20.685  -2.949  1.000 14.771 0 190 TYR   C CZ    1 ? 
ATOM   1486 O  OH    . TYR   A 1 190 ? 8.845   19.290  -3.054  1.000 15.389 0 190 TYR   C OH    1 ? 
ATOM   1487 N  N     . LYS   A 1 191 ? 8.897   28.174  -3.969  1.000 16.628 0 191 LYS   C N     1 ? 
ATOM   1488 C  CA    . LYS   A 1 191 ? 8.651   29.552  -3.540  1.000 19.580 0 191 LYS   C CA    1 ? 
ATOM   1489 C  C     . LYS   A 1 191 ? 7.832   30.305  -4.593  1.000 21.186 0 191 LYS   C C     1 ? 
ATOM   1490 O  O     . LYS   A 1 191 ? 8.363   31.116  -5.356  1.000 24.965 0 191 LYS   C O     1 ? 
ATOM   1491 C  CB    . LYS   A 1 191 ? 9.982   30.275  -3.267  1.000 21.531 0 191 LYS   C CB    1 ? 
ATOM   1492 C  CG    . LYS   A 1 191 ? 9.860   31.590  -2.508  1.000 26.285 0 191 LYS   C CG    1 ? 
ATOM   1493 C  CD    . LYS   A 1 191 ? 10.942  32.603  -2.871  1.000 29.493 0 191 LYS   C CD    1 ? 
ATOM   1494 C  CE    . LYS   A 1 191 ? 10.458  34.034  -2.756  1.000 33.489 0 191 LYS   C CE    1 ? 
ATOM   1495 N  NZ    . LYS   A 1 191 ? 10.133  34.397  -1.354  1.000 31.940 0 191 LYS   C NZ    1 ? 
ATOM   1496 N  N     . PHE   A 1 192 ? 6.510   30.099  -4.603  1.000 18.427 0 192 PHE   C N     1 ? 
ATOM   1497 C  CA    . PHE   A 1 192 ? 5.691   30.483  -5.755  1.000 18.206 0 192 PHE   C CA    1 ? 
ATOM   1498 C  C     . PHE   A 1 192 ? 4.955   31.815  -5.542  1.000 21.427 0 192 PHE   C C     1 ? 
ATOM   1499 O  O     . PHE   A 1 192 ? 4.193   32.223  -6.418  1.000 27.674 0 192 PHE   C O     1 ? 
ATOM   1500 C  CB    . PHE   A 1 192 ? 4.685   29.375  -6.109  1.000 17.432 0 192 PHE   C CB    1 ? 
ATOM   1501 C  CG    . PHE   A 1 192 ? 3.552   29.169  -5.125  1.000 16.615 0 192 PHE   C CG    1 ? 
ATOM   1502 C  CD1   . PHE   A 1 192 ? 2.378   29.896  -5.248  1.000 18.065 0 192 PHE   C CD1   1 ? 
ATOM   1503 C  CD2   . PHE   A 1 192 ? 3.641   28.254  -4.089  1.000 18.403 0 192 PHE   C CD2   1 ? 
ATOM   1504 C  CE1   . PHE   A 1 192 ? 1.357   29.746  -4.326  1.000 18.248 0 192 PHE   C CE1   1 ? 
ATOM   1505 C  CE2   . PHE   A 1 192 ? 2.605   28.096  -3.192  1.000 18.290 0 192 PHE   C CE2   1 ? 
ATOM   1506 C  CZ    . PHE   A 1 192 ? 1.466   28.842  -3.303  1.000 18.890 0 192 PHE   C CZ    1 ? 
ATOM   1507 N  N     . HIS   A 1 193 ? 5.093   32.448  -4.363  1.000 19.599 0 193 HIS   C N     1 ? 
ATOM   1508 C  CA    . HIS   A 1 193 ? 4.592   33.809  -4.133  1.000 21.120 0 193 HIS   C CA    1 ? 
ATOM   1509 C  C     . HIS   A 1 193 ? 5.665   34.616  -3.393  1.000 23.455 0 193 HIS   C C     1 ? 
ATOM   1510 O  O     . HIS   A 1 193 ? 6.499   34.058  -2.697  1.000 19.602 0 193 HIS   C O     1 ? 
ATOM   1511 C  CB    . HIS   A 1 193 ? 3.185   33.777  -3.510  1.000 20.401 0 193 HIS   C CB    1 ? 
ATOM   1512 C  CG    . HIS   A 1 193 ? 3.084   33.263  -2.103  1.000 18.404 0 193 HIS   C CG    1 ? 
ATOM   1513 N  ND1   . HIS   A 1 193 ? 2.794   31.948  -1.751  1.000 17.306 0 193 HIS   C ND1   1 ? 
ATOM   1514 C  CD2   . HIS   A 1 193 ? 3.272   33.901  -0.950  1.000 18.607 0 193 HIS   C CD2   1 ? 
ATOM   1515 C  CE1   . HIS   A 1 193 ? 2.778   31.851  -0.435  1.000 15.054 0 193 HIS   C CE1   1 ? 
ATOM   1516 N  NE2   . HIS   A 1 193 ? 3.090   33.044  0.073   1.000 19.745 0 193 HIS   C NE2   1 ? 
ATOM   1517 N  N     . LYS   A 1 194 ? 5.574   35.948  -3.460  1.000 24.807 0 194 LYS   C N     1 ? 
ATOM   1518 C  CA    . LYS   A 1 194 ? 6.692   36.851  -3.201  1.000 26.361 0 194 LYS   C CA    1 ? 
ATOM   1519 C  C     . LYS   A 1 194 ? 7.267   36.703  -1.792  1.000 23.635 0 194 LYS   C C     1 ? 
ATOM   1520 O  O     . LYS   A 1 194 ? 8.496   36.712  -1.621  1.000 25.004 0 194 LYS   C O     1 ? 
ATOM   1521 C  CB    . LYS   A 1 194 ? 6.183   38.279  -3.437  1.000 33.326 0 194 LYS   C CB    1 ? 
ATOM   1522 C  CG    . LYS   A 1 194 ? 7.145   39.430  -3.168  1.000 39.762 0 194 LYS   C CG    1 ? 
ATOM   1523 C  CD    . LYS   A 1 194 ? 6.417   40.780  -3.111  1.000 44.312 0 194 LYS   C CD    1 ? 
ATOM   1524 C  CE    . LYS   A 1 194 ? 7.336   41.983  -3.039  1.000 49.053 0 194 LYS   C CE    1 ? 
ATOM   1525 N  NZ    . LYS   A 1 194 ? 8.136   41.996  -1.790  1.000 46.479 0 194 LYS   C NZ    1 ? 
ATOM   1526 N  N     . LYS   A 1 195 ? 6.403   36.637  -0.766  1.000 19.587 0 195 LYS   C N     1 ? 
ATOM   1527 C  CA    . LYS   A 1 195 ? 6.848   36.608  0.620   1.000 21.571 0 195 LYS   C CA    1 ? 
ATOM   1528 C  C     . LYS   A 1 195 ? 6.812   35.192  1.205   1.000 19.692 0 195 LYS   C C     1 ? 
ATOM   1529 O  O     . LYS   A 1 195 ? 6.938   35.046  2.419   1.000 20.846 0 195 LYS   C O     1 ? 
ATOM   1530 C  CB    . LYS   A 1 195 ? 5.990   37.523  1.492   1.000 23.488 0 195 LYS   C CB    1 ? 
ATOM   1531 C  CG    . LYS   A 1 195 ? 6.109   39.020  1.198   1.000 27.901 0 195 LYS   C CG    1 ? 
ATOM   1532 C  CD    . LYS   A 1 195 ? 5.226   39.833  2.125   1.000 31.861 0 195 LYS   C CD    1 ? 
ATOM   1533 C  CE    . LYS   A 1 195 ? 5.251   41.323  1.844   1.000 37.295 0 195 LYS   C CE    1 ? 
ATOM   1534 N  NZ    . LYS   A 1 195 ? 6.569   41.910  2.173   1.000 41.240 0 195 LYS   C NZ    1 ? 
ATOM   1535 N  N     . LYS   A 1 196 ? 6.641   34.164  0.364   1.000 18.179 0 196 LYS   C N     1 ? 
ATOM   1536 C  CA    . LYS   A 1 196 ? 6.746   32.793  0.849   1.000 19.023 0 196 LYS   C CA    1 ? 
ATOM   1537 C  C     . LYS   A 1 196 ? 8.187   32.557  1.305   1.000 17.093 0 196 LYS   C C     1 ? 
ATOM   1538 O  O     . LYS   A 1 196 ? 9.106   32.808  0.535   1.000 16.624 0 196 LYS   C O     1 ? 
ATOM   1539 C  CB    . LYS   A 1 196 ? 6.380   31.781  -0.247  1.000 17.135 0 196 LYS   C CB    1 ? 
ATOM   1540 C  CG    . LYS   A 1 196 ? 6.237   30.330  0.221   1.000 17.351 0 196 LYS   C CG    1 ? 
ATOM   1541 C  CD    . LYS   A 1 196 ? 5.596   29.419  -0.814  1.000 16.513 0 196 LYS   C CD    1 ? 
ATOM   1542 C  CE    . LYS   A 1 196 ? 5.352   28.014  -0.315  1.000 17.224 0 196 LYS   C CE    1 ? 
ATOM   1543 N  NZ    . LYS   A 1 196 ? 6.583   27.345  0.232   1.000 17.336 0 196 LYS   C NZ    1 ? 
ATOM   1544 N  N     . SER   A 1 197 ? 8.384   31.988  2.493   1.000 18.942 0 197 SER   C N     1 ? 
ATOM   1545 C  CA    . SER   A 1 197 ? 9.745   31.734  2.944   1.000 18.338 0 197 SER   C CA    1 ? 
ATOM   1546 C  C     . SER   A 1 197 ? 10.359  30.621  2.096   1.000 17.312 0 197 SER   C C     1 ? 
ATOM   1547 O  O     . SER   A 1 197 ? 9.650   29.680  1.697   1.000 17.291 0 197 SER   C O     1 ? 
ATOM   1548 C  CB    . SER   A 1 197 ? 9.824   31.373  4.401   1.000 20.195 0 197 SER   C CB    1 ? 
ATOM   1549 O  OG    . SER   A 1 197 ? 9.057   30.223  4.636   1.000 26.220 0 197 SER   C OG    1 ? 
ATOM   1550 N  N     . VAL   A 1 198 ? 11.682  30.702  1.863   1.000 16.247 0 198 VAL   C N     1 ? 
ATOM   1551 C  CA    . VAL   A 1 198 ? 12.412  29.632  1.200   1.000 17.053 0 198 VAL   C CA    1 ? 
ATOM   1552 C  C     . VAL   A 1 198 ? 12.485  28.370  2.059   1.000 16.683 0 198 VAL   C C     1 ? 
ATOM   1553 O  O     . VAL   A 1 198 ? 12.651  27.265  1.511   1.000 18.278 0 198 VAL   C O     1 ? 
ATOM   1554 C  CB    . VAL   A 1 198 ? 13.846  30.060  0.831   1.000 19.779 0 198 VAL   C CB    1 ? 
ATOM   1555 C  CG1   . VAL   A 1 198 ? 14.661  30.485  2.045   1.000 22.492 0 198 VAL   C CG1   1 ? 
ATOM   1556 C  CG2   . VAL   A 1 198 ? 14.576  28.932  0.111   1.000 22.519 0 198 VAL   C CG2   1 ? 
ATOM   1557 N  N     . ASP   A 1 199 ? 12.405  28.562  3.363   1.000 15.920 0 199 ASP   C N     1 ? 
ATOM   1558 C  CA    . ASP   A 1 199 ? 12.617  27.484  4.317   1.000 18.073 0 199 ASP   C CA    1 ? 
ATOM   1559 C  C     . ASP   A 1 199 ? 11.311  27.191  5.031   1.000 17.094 0 199 ASP   C C     1 ? 
ATOM   1560 O  O     . ASP   A 1 199 ? 10.296  27.856  4.852   1.000 17.499 0 199 ASP   C O     1 ? 
ATOM   1561 C  CB    . ASP   A 1 199 ? 13.779  27.774  5.273   1.000 20.305 0 199 ASP   C CB    1 ? 
ATOM   1562 C  CG    . ASP   A 1 199 ? 13.769  29.071  6.049   1.000 22.930 0 199 ASP   C CG    1 ? 
ATOM   1563 O  OD1   . ASP   A 1 199 ? 12.800  29.836  5.973   1.000 24.078 0 199 ASP   C OD1   1 ? 
ATOM   1564 O  OD2   . ASP   A 1 199 ? 14.798  29.313  6.734   1.000 33.001 0 199 ASP   C OD2   1 ? 
ATOM   1565 N  N     . ILE   A 1 200 ? 11.355  26.126  5.826   1.000 16.805 0 200 ILE   C N     1 ? 
ATOM   1566 C  CA    . ILE   A 1 200 ? 10.190  25.683  6.573   1.000 15.183 0 200 ILE   C CA    1 ? 
ATOM   1567 C  C     . ILE   A 1 200 ? 10.624  25.424  8.005   1.000 14.701 0 200 ILE   C C     1 ? 
ATOM   1568 O  O     . ILE   A 1 200 ? 11.723  24.948  8.243   1.000 14.888 0 200 ILE   C O     1 ? 
ATOM   1569 C  CB    . ILE   A 1 200 ? 9.567   24.433  5.922   1.000 16.779 0 200 ILE   C CB    1 ? 
ATOM   1570 C  CG1   . ILE   A 1 200 ? 8.243   24.052  6.591   1.000 19.585 0 200 ILE   C CG1   1 ? 
ATOM   1571 C  CG2   . ILE   A 1 200 ? 10.527  23.254  5.867   1.000 16.139 0 200 ILE   C CG2   1 ? 
ATOM   1572 C  CD1   . ILE   A 1 200 ? 7.418   23.103  5.727   1.000 22.905 0 200 ILE   C CD1   1 ? 
ATOM   1573 N  N     . GLU   A 1 201 ? 9.775   25.824  8.964   1.000 16.138 0 201 GLU   C N     1 ? 
ATOM   1574 C  CA    . GLU   A 1 201 ? 9.985   25.583  10.377  1.000 15.217 0 201 GLU   C CA    1 ? 
ATOM   1575 C  C     . GLU   A 1 201 ? 9.195   24.343  10.788  1.000 12.659 0 201 GLU   C C     1 ? 
ATOM   1576 O  O     . GLU   A 1 201 ? 7.984   24.304  10.607  1.000 13.350 0 201 GLU   C O     1 ? 
ATOM   1577 C  CB    . GLU   A 1 201 ? 9.482   26.785  11.166  1.000 18.383 0 201 GLU   C CB    1 ? 
ATOM   1578 C  CG    . GLU   A 1 201 ? 10.481  27.925  11.150  1.000 24.072 0 201 GLU   C CG    1 ? 
ATOM   1579 C  CD    . GLU   A 1 201 ? 10.033  29.203  11.831  1.000 31.601 0 201 GLU   C CD    1 ? 
ATOM   1580 O  OE1   . GLU   A 1 201 ? 8.829   29.322  12.164  1.000 34.530 0 201 GLU   C OE1   1 ? 
ATOM   1581 O  OE2   . GLU   A 1 201 ? 10.902  30.080  12.005  1.000 35.322 0 201 GLU   C OE2   1 ? 
ATOM   1582 N  N     . VAL   A 1 202 ? 9.931   23.331  11.237  1.000 11.534 0 202 VAL   C N     1 ? 
ATOM   1583 C  CA    . VAL   A 1 202 ? 9.354   22.063  11.633  1.000 12.220 0 202 VAL   C CA    1 ? 
ATOM   1584 C  C     . VAL   A 1 202 ? 9.700   21.738  13.074  1.000 11.138 0 202 VAL   C C     1 ? 
ATOM   1585 O  O     . VAL   A 1 202 ? 10.726  22.129  13.571  1.000 12.706 0 202 VAL   C O     1 ? 
ATOM   1586 C  CB    . VAL   A 1 202 ? 9.834   20.928  10.711  1.000 13.643 0 202 VAL   C CB    1 ? 
ATOM   1587 C  CG1   . VAL   A 1 202 ? 9.301   21.126  9.310   1.000 14.480 0 202 VAL   C CG1   1 ? 
ATOM   1588 C  CG2   . VAL   A 1 202 ? 11.346  20.727  10.706  1.000 13.398 0 202 VAL   C CG2   1 ? 
ATOM   1589 N  N     . ASP   A 1 203 ? 8.865   20.886  13.674  1.000 10.684 0 203 ASP   C N     1 ? 
ATOM   1590 C  CA    . ASP   A 1 203 ? 9.108   20.264  14.954  1.000 9.954  0 203 ASP   C CA    1 ? 
ATOM   1591 C  C     . ASP   A 1 203 ? 9.547   18.821  14.710  1.000 9.046  0 203 ASP   C C     1 ? 
ATOM   1592 O  O     . ASP   A 1 203 ? 8.869   18.173  13.909  1.000 9.573  0 203 ASP   C O     1 ? 
ATOM   1593 C  CB    . ASP   A 1 203 ? 7.826   20.248  15.789  1.000 11.044 0 203 ASP   C CB    1 ? 
ATOM   1594 C  CG    . ASP   A 1 203 ? 7.282   21.607  16.186  1.000 12.438 0 203 ASP   C CG    1 ? 
ATOM   1595 O  OD1   . ASP   A 1 203 ? 8.078   22.571  16.181  1.000 13.578 0 203 ASP   C OD1   1 ? 
ATOM   1596 O  OD2   . ASP   A 1 203 ? 6.059   21.672  16.552  1.000 12.953 0 203 ASP   C OD2   1 ? 
ATOM   1597 N  N     . LEU   A 1 204 ? 10.603  18.383  15.380  1.000 8.758  0 204 LEU   C N     1 ? 
ATOM   1598 C  CA    . LEU   A 1 204 ? 10.884  16.954  15.480  1.000 8.772  0 204 LEU   C CA    1 ? 
ATOM   1599 C  C     . LEU   A 1 204 ? 10.077  16.477  16.681  1.000 8.944  0 204 LEU   C C     1 ? 
ATOM   1600 O  O     . LEU   A 1 204 ? 10.289  16.973  17.794  1.000 9.682  0 204 LEU   C O     1 ? 
ATOM   1601 C  CB    . LEU   A 1 204 ? 12.385  16.692  15.680  1.000 9.770  0 204 LEU   C CB    1 ? 
ATOM   1602 C  CG    . LEU   A 1 204 ? 12.781  15.257  15.993  1.000 10.899 0 204 LEU   C CG    1 ? 
ATOM   1603 C  CD1   . LEU   A 1 204 ? 12.355  14.302  14.902  1.000 11.619 0 204 LEU   C CD1   1 ? 
ATOM   1604 C  CD2   . LEU   A 1 204 ? 14.267  15.152  16.241  1.000 11.295 0 204 LEU   C CD2   1 ? 
ATOM   1605 N  N     . ILE   A 1 205 ? 9.225   15.471  16.472  1.000 7.978  0 205 ILE   C N     1 ? 
ATOM   1606 C  CA    . ILE   A 1 205 ? 8.287   15.036  17.495  1.000 8.332  0 205 ILE   C CA    1 ? 
ATOM   1607 C  C     . ILE   A 1 205 ? 8.503   13.536  17.713  1.000 8.538  0 205 ILE   C C     1 ? 
ATOM   1608 O  O     . ILE   A 1 205 ? 8.566   12.775  16.768  1.000 9.991  0 205 ILE   C O     1 ? 
ATOM   1609 C  CB    . ILE   A 1 205 ? 6.835   15.335  17.123  1.000 8.656  0 205 ILE   C CB    1 ? 
ATOM   1610 C  CG1   . ILE   A 1 205 ? 6.651   16.802  16.723  1.000 9.548  0 205 ILE   C CG1   1 ? 
ATOM   1611 C  CG2   . ILE   A 1 205 ? 5.903   14.905  18.251  1.000 8.702  0 205 ILE   C CG2   1 ? 
ATOM   1612 C  CD1   . ILE   A 1 205 ? 5.222   17.158  16.339  1.000 11.175 0 205 ILE   C CD1   1 ? 
ATOM   1613 N  N     . ARG   A 1 206 ? 8.539   13.132  18.966  1.000 8.275  0 206 ARG   C N     1 ? 
ATOM   1614 C  CA    . ARG   A 1 206 ? 8.507   11.729  19.358  1.000 8.694  0 206 ARG   C CA    1 ? 
ATOM   1615 C  C     . ARG   A 1 206 ? 7.122   11.382  19.888  1.000 9.051  0 206 ARG   C C     1 ? 
ATOM   1616 O  O     . ARG   A 1 206 ? 6.629   11.993  20.868  1.000 9.513  0 206 ARG   C O     1 ? 
ATOM   1617 C  CB    . ARG   A 1 206 ? 9.512   11.417  20.473  1.000 9.023  0 206 ARG   C CB    1 ? 
ATOM   1618 C  CG    . ARG   A 1 206 ? 9.578   9.945   20.845  1.000 9.853  0 206 ARG   C CG    1 ? 
ATOM   1619 C  CD    . ARG   A 1 206 ? 10.639  9.680   21.931  1.000 10.684 0 206 ARG   C CD    1 ? 
ATOM   1620 N  NE    . ARG   A 1 206 ? 10.909  8.258   22.052  1.000 11.585 0 206 ARG   C NE    1 ? 
ATOM   1621 C  CZ    . ARG   A 1 206 ? 10.408  7.420   22.950  1.000 12.195 0 206 ARG   C CZ    1 ? 
ATOM   1622 N  NH1   . ARG   A 1 206 ? 9.592   7.877   23.889  1.000 14.302 0 206 ARG   C NH1   1 ? 
ATOM   1623 N  NH2   . ARG   A 1 206 ? 10.790  6.141   22.945  1.000 12.581 0 206 ARG   C NH2   1 ? 
ATOM   1624 N  N     . PHE   A 1 207 ? 6.492   10.387  19.274  1.000 8.099  0 207 PHE   C N     1 ? 
ATOM   1625 C  CA    . PHE   A 1 207 ? 5.209   9.862   19.721  1.000 8.627  0 207 PHE   C CA    1 ? 
ATOM   1626 C  C     . PHE   A 1 207 ? 5.432   8.499   20.331  1.000 9.506  0 207 PHE   C C     1 ? 
ATOM   1627 O  O     . PHE   A 1 207 ? 6.171   7.708   19.780  1.000 10.332 0 207 PHE   C O     1 ? 
ATOM   1628 C  CB    . PHE   A 1 207 ? 4.226   9.755   18.551  1.000 9.487  0 207 PHE   C CB    1 ? 
ATOM   1629 C  CG    . PHE   A 1 207 ? 3.982   11.011  17.757  1.000 9.012  0 207 PHE   C CG    1 ? 
ATOM   1630 C  CD1   . PHE   A 1 207 ? 4.775   11.348  16.676  1.000 9.254  0 207 PHE   C CD1   1 ? 
ATOM   1631 C  CD2   . PHE   A 1 207 ? 2.932   11.855  18.059  1.000 10.520 0 207 PHE   C CD2   1 ? 
ATOM   1632 C  CE1   . PHE   A 1 207 ? 4.575   12.524  15.975  1.000 9.870  0 207 PHE   C CE1   1 ? 
ATOM   1633 C  CE2   . PHE   A 1 207 ? 2.693   12.990  17.309  1.000 11.086 0 207 PHE   C CE2   1 ? 
ATOM   1634 C  CZ    . PHE   A 1 207 ? 3.491   13.333  16.261  1.000 11.015 0 207 PHE   C CZ    1 ? 
ATOM   1635 N  N     . SER   A 1 208 ? 4.758   8.221   21.453  1.000 9.446  0 208 SER   C N     1 ? 
ATOM   1636 C  CA    . SER   A 1 208 ? 4.938   6.929   22.103  1.000 10.336 0 208 SER   C CA    1 ? 
ATOM   1637 C  C     . SER   A 1 208 ? 3.660   6.577   22.855  1.000 11.126 0 208 SER   C C     1 ? 
ATOM   1638 O  O     . SER   A 1 208 ? 2.665   7.280   22.742  1.000 12.871 0 208 SER   C O     1 ? 
ATOM   1639 C  CB    . SER   A 1 208 ? 6.140   6.970   22.989  1.000 11.592 0 208 SER   C CB    1 ? 
ATOM   1640 O  OG    . SER   A 1 208 ? 5.986   7.997   23.980  1.000 13.543 0 208 SER   C OG    1 ? 
ATOM   1641 N  N     . PHE   A 1 209 ? 3.689   5.407   23.500  1.000 13.209 0 209 PHE   C N     1 ? 
ATOM   1642 C  CA    . PHE   A 1 209 ? 2.444   4.787   23.927  1.000 15.519 0 209 PHE   C CA    1 ? 
ATOM   1643 C  C     . PHE   A 1 209 ? 2.340   4.691   25.451  1.000 21.249 0 209 PHE   C C     1 ? 
ATOM   1644 O  O     . PHE   A 1 209 ? 3.386   4.689   26.087  1.000 21.977 0 209 PHE   C O     1 ? 
ATOM   1645 C  CB    . PHE   A 1 209 ? 2.326   3.402   23.294  1.000 14.778 0 209 PHE   C CB    1 ? 
ATOM   1646 C  CG    . PHE   A 1 209 ? 2.334   3.447   21.787  1.000 13.789 0 209 PHE   C CG    1 ? 
ATOM   1647 C  CD1   . PHE   A 1 209 ? 1.189   3.809   21.112  1.000 14.352 0 209 PHE   C CD1   1 ? 
ATOM   1648 C  CD2   . PHE   A 1 209 ? 3.487   3.245   21.059  1.000 12.584 0 209 PHE   C CD2   1 ? 
ATOM   1649 C  CE1   . PHE   A 1 209 ? 1.185   3.902   19.741  1.000 15.159 0 209 PHE   C CE1   1 ? 
ATOM   1650 C  CE2   . PHE   A 1 209 ? 3.472   3.346   19.674  1.000 13.225 0 209 PHE   C CE2   1 ? 
ATOM   1651 C  CZ    . PHE   A 1 209 ? 2.314   3.670   19.026  1.000 14.400 0 209 PHE   C CZ    1 ? 
ATOM   1652 O  OXT   . PHE   A 1 209 ? 1.154   4.576   25.915  1.000 25.301 0 209 PHE   C OXT   1 ? 
ATOM   1653 N  N     . MET   B 2 1   ? 13.524  -8.494  -1.852  1.000 8.258  0 1   MET   D N     1 ? 
ATOM   1654 C  CA    . MET   B 2 1   ? 12.691  -8.682  -0.641  1.000 7.801  0 1   MET   D CA    1 ? 
ATOM   1655 C  C     . MET   B 2 1   ? 13.229  -9.870  0.115   1.000 7.627  0 1   MET   D C     1 ? 
ATOM   1656 O  O     . MET   B 2 1   ? 13.250  -11.012 -0.382  1.000 8.076  0 1   MET   D O     1 ? 
ATOM   1657 C  CB    . MET   B 2 1   ? 11.239  -8.955  -1.026  1.000 8.526  0 1   MET   D CB    1 ? 
ATOM   1658 C  CG    . MET   B 2 1   ? 10.343  -9.041  0.179   1.000 8.439  0 1   MET   D CG    1 ? 
ATOM   1659 S  SD    . MET   B 2 1   ? 8.790   -9.921  -0.178  1.000 9.623  0 1   MET   D SD    1 ? 
ATOM   1660 C  CE    . MET   B 2 1   ? 9.419   -11.570 -0.511  1.000 9.867  0 1   MET   D CE    1 ? 
ATOM   1661 N  N     . LYS   B 2 2   ? 13.558  -9.639  1.388   1.000 7.036  0 2   LYS   D N     1 ? 
ATOM   1662 C  CA    . LYS   B 2 2   ? 13.956  -10.671 2.339   1.000 6.758  0 2   LYS   D CA    1 ? 
ATOM   1663 C  C     . LYS   B 2 2   ? 12.757  -11.421 2.918   1.000 7.357  0 2   LYS   D C     1 ? 
ATOM   1664 O  O     . LYS   B 2 2   ? 11.646  -10.863 2.907   1.000 7.553  0 2   LYS   D O     1 ? 
ATOM   1665 C  CB    . LYS   B 2 2   ? 14.768  -10.047 3.457   1.000 8.093  0 2   LYS   D CB    1 ? 
ATOM   1666 C  CG    . LYS   B 2 2   ? 16.038  -9.326  2.986   1.000 8.598  0 2   LYS   D CG    1 ? 
ATOM   1667 C  CD    . LYS   B 2 2   ? 16.572  -8.441  4.067   1.000 9.442  0 2   LYS   D CD    1 ? 
ATOM   1668 C  CE    . LYS   B 2 2   ? 17.696  -7.520  3.629   1.000 11.067 0 2   LYS   D CE    1 ? 
ATOM   1669 N  NZ    . LYS   B 2 2   ? 18.859  -8.289  3.117   1.000 13.223 0 2   LYS   D NZ    1 ? 
ATOM   1670 N  N     . LEU   B 2 3   ? 12.968  -12.610 3.483   1.000 7.461  0 3   LEU   D N     1 ? 
ATOM   1671 C  CA    . LEU   B 2 3   ? 11.836  -13.317 4.084   1.000 6.768  0 3   LEU   D CA    1 ? 
ATOM   1672 C  C     . LEU   B 2 3   ? 11.327  -12.689 5.368   1.000 7.384  0 3   LEU   D C     1 ? 
ATOM   1673 O  O     . LEU   B 2 3   ? 10.103  -12.771 5.641   1.000 7.801  0 3   LEU   D O     1 ? 
ATOM   1674 C  CB    . LEU   B 2 3   ? 12.113  -14.816 4.282   1.000 7.148  0 3   LEU   D CB    1 ? 
ATOM   1675 C  CG    . LEU   B 2 3   ? 12.139  -15.595 2.974   1.000 8.528  0 3   LEU   D CG    1 ? 
ATOM   1676 C  CD1   . LEU   B 2 3   ? 12.333  -17.066 3.278   1.000 9.293  0 3   LEU   D CD1   1 ? 
ATOM   1677 C  CD2   . LEU   B 2 3   ? 10.913  -15.424 2.127   1.000 8.970  0 3   LEU   D CD2   1 ? 
ATOM   1678 N  N     . LEU   B 2 4   ? 12.164  -11.973 6.137   1.000 6.478  0 4   LEU   D N     1 ? 
ATOM   1679 C  CA    . LEU   B 2 4   ? 11.607  -11.243 7.282   1.000 6.886  0 4   LEU   D CA    1 ? 
ATOM   1680 C  C     . LEU   B 2 4   ? 10.625  -10.179 6.765   1.000 7.396  0 4   LEU   D C     1 ? 
ATOM   1681 O  O     . LEU   B 2 4   ? 9.531   -10.016 7.304   1.000 7.332  0 4   LEU   D O     1 ? 
ATOM   1682 C  CB    . LEU   B 2 4   ? 12.711  -10.604 8.136   1.000 6.951  0 4   LEU   D CB    1 ? 
ATOM   1683 C  CG    . LEU   B 2 4   ? 12.208  -9.824  9.354   1.000 7.785  0 4   LEU   D CG    1 ? 
ATOM   1684 C  CD1   . LEU   B 2 4   ? 11.310  -10.661 10.255  1.000 8.963  0 4   LEU   D CD1   1 ? 
ATOM   1685 C  CD2   . LEU   B 2 4   ? 13.353  -9.258  10.172  1.000 8.649  0 4   LEU   D CD2   1 ? 
ATOM   1686 N  N     . THR   B 2 5   ? 11.012  -9.467  5.697   1.000 7.015  0 5   THR   D N     1 ? 
ATOM   1687 C  CA    . THR   B 2 5   ? 10.168  -8.424  5.113   1.000 6.654  0 5   THR   D CA    1 ? 
ATOM   1688 C  C     . THR   B 2 5   ? 8.853   -9.040  4.619   1.000 6.466  0 5   THR   D C     1 ? 
ATOM   1689 O  O     . THR   B 2 5   ? 7.754   -8.519  4.902   1.000 7.571  0 5   THR   D O     1 ? 
ATOM   1690 C  CB    . THR   B 2 5   ? 10.874  -7.702  3.965   1.000 7.278  0 5   THR   D CB    1 ? 
ATOM   1691 O  OG1   . THR   B 2 5   ? 12.138  -7.329  4.537   1.000 8.513  0 5   THR   D OG1   1 ? 
ATOM   1692 C  CG2   . THR   B 2 5   ? 10.115  -6.466  3.514   1.000 7.929  0 5   THR   D CG2   1 ? 
ATOM   1693 N  N     . HIS   B 2 6   ? 8.900   -10.190 3.946   1.000 6.439  0 6   HIS   D N     1 ? 
ATOM   1694 C  CA    . HIS   B 2 6   ? 7.670   -10.891 3.515   1.000 6.752  0 6   HIS   D CA    1 ? 
ATOM   1695 C  C     . HIS   B 2 6   ? 6.794   -11.189 4.723   1.000 6.891  0 6   HIS   D C     1 ? 
ATOM   1696 O  O     . HIS   B 2 6   ? 5.559   -11.039 4.673   1.000 7.404  0 6   HIS   D O     1 ? 
ATOM   1697 C  CB    . HIS   B 2 6   ? 8.034   -12.230 2.852   1.000 7.151  0 6   HIS   D CB    1 ? 
ATOM   1698 C  CG    . HIS   B 2 6   ? 6.852   -13.149 2.724   1.000 7.274  0 6   HIS   D CG    1 ? 
ATOM   1699 N  ND1   . HIS   B 2 6   ? 5.872   -13.153 1.767   1.000 10.199 0 6   HIS   D ND1   1 ? 
ATOM   1700 C  CD2   . HIS   B 2 6   ? 6.530   -14.131 3.593   1.000 7.061  0 6   HIS   D CD2   1 ? 
ATOM   1701 C  CE1   . HIS   B 2 6   ? 5.006   -14.126 2.072   1.000 6.751  0 6   HIS   D CE1   1 ? 
ATOM   1702 N  NE2   . HIS   B 2 6   ? 5.388   -14.721 3.164   1.000 10.570 0 6   HIS   D NE2   1 ? 
ATOM   1703 N  N     . ASN   B 2 7   ? 7.406   -11.580 5.835   1.000 6.854  0 7   ASN   D N     1 ? 
ATOM   1704 C  CA    . ASN   B 2 7   ? 6.656   -11.948 7.032   1.000 7.270  0 7   ASN   D CA    1 ? 
ATOM   1705 C  C     . ASN   B 2 7   ? 5.934   -10.730 7.589   1.000 7.563  0 7   ASN   D C     1 ? 
ATOM   1706 O  O     . ASN   B 2 7   ? 4.770   -10.840 7.978   1.000 7.872  0 7   ASN   D O     1 ? 
ATOM   1707 C  CB    . ASN   B 2 7   ? 7.563   -12.591 8.091   1.000 7.403  0 7   ASN   D CB    1 ? 
ATOM   1708 C  CG    . ASN   B 2 7   ? 6.851   -13.650 8.889   1.000 8.162  0 7   ASN   D CG    1 ? 
ATOM   1709 O  OD1   . ASN   B 2 7   ? 6.746   -14.819 8.484   1.000 10.267 0 7   ASN   D OD1   1 ? 
ATOM   1710 N  ND2   . ASN   B 2 7   ? 6.401   -13.284 10.048  1.000 6.825  0 7   ASN   D ND2   1 ? 
ATOM   1711 N  N     . LEU   B 2 8   ? 6.609   -9.585  7.659   1.000 7.712  0 8   LEU   D N     1 ? 
ATOM   1712 C  CA    . LEU   B 2 8   ? 5.985   -8.370  8.159   1.000 8.289  0 8   LEU   D CA    1 ? 
ATOM   1713 C  C     . LEU   B 2 8   ? 4.865   -7.909  7.231   1.000 8.168  0 8   LEU   D C     1 ? 
ATOM   1714 O  O     . LEU   B 2 8   ? 3.813   -7.527  7.690   1.000 8.531  0 8   LEU   D O     1 ? 
ATOM   1715 C  CB    . LEU   B 2 8   ? 7.058   -7.298  8.372   1.000 9.158  0 8   LEU   D CB    1 ? 
ATOM   1716 C  CG    . LEU   B 2 8   ? 8.180   -7.670  9.340   1.000 9.834  0 8   LEU   D CG    1 ? 
ATOM   1717 C  CD1   . LEU   B 2 8   ? 9.191   -6.521  9.422   1.000 12.968 0 8   LEU   D CD1   1 ? 
ATOM   1718 C  CD2   . LEU   B 2 8   ? 7.675   -8.048  10.717  1.000 10.951 0 8   LEU   D CD2   1 ? 
ATOM   1719 N  N     . LEU   B 2 9   ? 5.119   -7.898  5.938   1.000 7.313  0 9   LEU   D N     1 ? 
ATOM   1720 C  CA    . LEU   B 2 9   ? 4.129   -7.487  4.954   1.000 7.470  0 9   LEU   D CA    1 ? 
ATOM   1721 C  C     . LEU   B 2 9   ? 2.857   -8.309  5.094   1.000 8.464  0 9   LEU   D C     1 ? 
ATOM   1722 O  O     . LEU   B 2 9   ? 1.744   -7.783  4.863   1.000 9.805  0 9   LEU   D O     1 ? 
ATOM   1723 C  CB    . LEU   B 2 9   ? 4.634   -7.616  3.508   1.000 7.962  0 9   LEU   D CB    1 ? 
ATOM   1724 C  CG    . LEU   B 2 9   ? 5.715   -6.630  3.060   1.000 8.845  0 9   LEU   D CG    1 ? 
ATOM   1725 C  CD1   . LEU   B 2 9   ? 6.343   -7.127  1.756   1.000 9.969  0 9   LEU   D CD1   1 ? 
ATOM   1726 C  CD2   . LEU   B 2 9   ? 5.151   -5.220  2.901   1.000 9.447  0 9   LEU   D CD2   1 ? 
ATOM   1727 N  N     . SER   B 2 10  ? 3.045   -9.591  5.344   1.000 8.185  0 10  SER   D N     1 ? 
ATOM   1728 C  CA    . SER   B 2 10  ? 2.001   -10.596 5.387   1.000 8.285  0 10  SER   D CA    1 ? 
ATOM   1729 C  C     . SER   B 2 10  ? 1.246   -10.657 6.722   1.000 9.419  0 10  SER   D C     1 ? 
ATOM   1730 O  O     . SER   B 2 10  ? 0.251   -11.386 6.833   1.000 10.512 0 10  SER   D O     1 ? 
ATOM   1731 C  CB    . SER   B 2 10  ? 2.603   -11.950 5.103   1.000 8.554  0 10  SER   D CB    1 ? 
ATOM   1732 O  OG    . SER   B 2 10  ? 3.011   -12.056 3.748   1.000 9.109  0 10  SER   D OG    1 ? 
ATOM   1733 N  N     . SER   B 2 11  ? 1.726   -9.954  7.746   1.000 8.825  0 11  SER   D N     1 ? 
ATOM   1734 C  CA    . SER   B 2 11  ? 1.345   -10.238 9.123   1.000 8.520  0 11  SER   D CA    1 ? 
ATOM   1735 C  C     . SER   B 2 11  ? -0.021  -9.715  9.510   1.000 9.699  0 11  SER   D C     1 ? 
ATOM   1736 O  O     . SER   B 2 11  ? -0.508  -8.717  8.978   1.000 9.515  0 11  SER   D O     1 ? 
ATOM   1737 C  CB    . SER   B 2 11  ? 2.399   -9.697  10.047  1.000 8.188  0 11  SER   D CB    1 ? 
ATOM   1738 O  OG    . SER   B 2 11  ? 2.382   -8.269  10.025  1.000 9.589  0 11  SER   D OG    1 ? 
ATOM   1739 N  N     . HIS   B 2 12  ? -0.585  -10.400 10.519  1.000 10.626 0 12  HIS   D N     1 ? 
ATOM   1740 C  CA    . HIS   B 2 12  ? -1.770  -9.917  11.219  1.000 11.257 0 12  HIS   D CA    1 ? 
ATOM   1741 C  C     . HIS   B 2 12  ? -1.610  -10.286 12.684  1.000 12.821 0 12  HIS   D C     1 ? 
ATOM   1742 O  O     . HIS   B 2 12  ? -1.157  -11.396 13.003  1.000 13.123 0 12  HIS   D O     1 ? 
ATOM   1743 C  CB    . HIS   B 2 12  ? -3.053  -10.608 10.718  1.000 12.713 0 12  HIS   D CB    1 ? 
ATOM   1744 C  CG    . HIS   B 2 12  ? -3.251  -10.500 9.270   1.000 15.067 0 12  HIS   D CG    1 ? 
ATOM   1745 N  ND1   . HIS   B 2 12  ? -3.988  -9.550  8.597   1.000 19.730 0 12  HIS   D ND1   1 ? 
ATOM   1746 C  CD2   . HIS   B 2 12  ? -2.632  -11.220 8.311   1.000 13.910 0 12  HIS   D CD2   1 ? 
ATOM   1747 C  CE1   . HIS   B 2 12  ? -3.905  -9.789  7.288   1.000 18.088 0 12  HIS   D CE1   1 ? 
ATOM   1748 N  NE2   . HIS   B 2 12  ? -3.011  -10.748 7.081   1.000 18.285 0 12  HIS   D NE2   1 ? 
ATOM   1749 N  N     . VAL   B 2 13  ? -2.099  -9.414  13.568  1.000 12.810 0 13  VAL   D N     1 ? 
ATOM   1750 C  CA    . VAL   B 2 13  ? -2.105  -9.703  14.995  1.000 13.440 0 13  VAL   D CA    1 ? 
ATOM   1751 C  C     . VAL   B 2 13  ? -3.185  -10.740 15.313  1.000 14.075 0 13  VAL   D C     1 ? 
ATOM   1752 O  O     . VAL   B 2 13  ? -4.327  -10.536 14.992  1.000 15.549 0 13  VAL   D O     1 ? 
ATOM   1753 C  CB    . VAL   B 2 13  ? -2.362  -8.427  15.788  1.000 14.422 0 13  VAL   D CB    1 ? 
ATOM   1754 C  CG1   . VAL   B 2 13  ? -2.498  -8.749  17.286  1.000 14.360 0 13  VAL   D CG1   1 ? 
ATOM   1755 C  CG2   . VAL   B 2 13  ? -1.235  -7.436  15.496  1.000 14.689 0 13  VAL   D CG2   1 ? 
ATOM   1756 N  N     . ARG   B 2 14  ? -2.774  -11.880 15.847  1.000 15.589 0 14  ARG   D N     1 ? 
ATOM   1757 C  CA    . ARG   B 2 14  ? -3.741  -12.929 16.166  1.000 15.943 0 14  ARG   D CA    1 ? 
ATOM   1758 C  C     . ARG   B 2 14  ? -4.457  -12.617 17.482  1.000 13.890 0 14  ARG   D C     1 ? 
ATOM   1759 O  O     . ARG   B 2 14  ? -3.821  -12.299 18.479  1.000 14.820 0 14  ARG   D O     1 ? 
ATOM   1760 C  CB    . ARG   B 2 14  ? -3.021  -14.282 16.276  1.000 19.559 0 14  ARG   D CB    1 ? 
ATOM   1761 C  CG    . ARG   B 2 14  ? -2.704  -14.888 14.913  1.000 21.655 0 14  ARG   D CG    1 ? 
ATOM   1762 C  CD    . ARG   B 2 14  ? -2.460  -16.386 14.929  1.000 25.179 0 14  ARG   D CD    1 ? 
ATOM   1763 N  NE    . ARG   B 2 14  ? -3.691  -17.164 15.069  1.000 28.213 0 14  ARG   D NE    1 ? 
ATOM   1764 C  CZ    . ARG   B 2 14  ? -3.773  -18.374 15.632  1.000 29.440 0 14  ARG   D CZ    1 ? 
ATOM   1765 N  NH1   . ARG   B 2 14  ? -4.935  -19.005 15.686  1.000 31.974 0 14  ARG   D NH1   1 ? 
ATOM   1766 N  NH2   . ARG   B 2 14  ? -2.706  -18.913 16.188  1.000 28.614 0 14  ARG   D NH2   1 ? 
ATOM   1767 N  N     . GLY   B 2 15  ? -5.789  -12.653 17.427  1.000 15.185 0 15  GLY   D N     1 ? 
ATOM   1768 C  CA    . GLY   B 2 15  ? -6.605  -12.291 18.570  1.000 15.235 0 15  GLY   D CA    1 ? 
ATOM   1769 C  C     . GLY   B 2 15  ? -7.893  -13.098 18.518  1.000 15.804 0 15  GLY   D C     1 ? 
ATOM   1770 O  O     . GLY   B 2 15  ? -7.911  -14.240 18.042  1.000 16.078 0 15  GLY   D O     1 ? 
ATOM   1771 N  N     . VAL   B 2 16  ? -8.991  -12.486 18.969  1.000 14.626 0 16  VAL   D N     1 ? 
ATOM   1772 C  CA    . VAL   B 2 16  ? -10.270 -13.180 19.094  1.000 16.866 0 16  VAL   D CA    1 ? 
ATOM   1773 C  C     . VAL   B 2 16  ? -11.031 -13.240 17.768  1.000 21.875 0 16  VAL   D C     1 ? 
ATOM   1774 O  O     . VAL   B 2 16  ? -11.946 -14.042 17.596  1.000 21.550 0 16  VAL   D O     1 ? 
ATOM   1775 C  CB    . VAL   B 2 16  ? -11.153 -12.515 20.169  1.000 19.314 0 16  VAL   D CB    1 ? 
ATOM   1776 C  CG1   . VAL   B 2 16  ? -11.679 -11.152 19.715  1.000 20.744 0 16  VAL   D CG1   1 ? 
ATOM   1777 C  CG2   . VAL   B 2 16  ? -12.289 -13.430 20.602  1.000 21.170 0 16  VAL   D CG2   1 ? 
ATOM   1778 N  N     . GLY   B 2 17  ? -10.636 -12.403 16.814  1.000 21.446 0 17  GLY   D N     1 ? 
ATOM   1779 C  CA    . GLY   B 2 17  ? -11.241 -12.410 15.495  1.000 22.479 0 17  GLY   D CA    1 ? 
ATOM   1780 C  C     . GLY   B 2 17  ? -10.651 -13.493 14.611  1.000 24.309 0 17  GLY   D C     1 ? 
ATOM   1781 O  O     . GLY   B 2 17  ? -9.733  -14.211 15.001  1.000 23.649 0 17  GLY   D O     1 ? 
ATOM   1782 N  N     . SER   B 2 18  ? -11.211 -13.616 13.414  1.000 28.978 0 18  SER   D N     1 ? 
ATOM   1783 C  CA    . SER   B 2 18  ? -10.775 -14.640 12.483  1.000 29.282 0 18  SER   D CA    1 ? 
ATOM   1784 C  C     . SER   B 2 18  ? -9.333  -14.407 12.039  1.000 26.978 0 18  SER   D C     1 ? 
ATOM   1785 O  O     . SER   B 2 18  ? -8.817  -13.289 12.059  1.000 25.689 0 18  SER   D O     1 ? 
ATOM   1786 C  CB    . SER   B 2 18  ? -11.727 -14.736 11.304  1.000 34.156 0 18  SER   D CB    1 ? 
ATOM   1787 O  OG    . SER   B 2 18  ? -12.038 -13.449 10.789  1.000 40.715 0 18  SER   D OG    1 ? 
ATOM   1788 N  N     . ARG   B 2 19  ? -8.725  -15.510 11.618  1.000 29.150 0 19  ARG   D N     1 ? 
ATOM   1789 C  CA    . ARG   B 2 19  ? -7.369  -15.571 11.105  1.000 33.407 0 19  ARG   D CA    1 ? 
ATOM   1790 C  C     . ARG   B 2 19  ? -7.243  -14.725 9.837   1.000 28.959 0 19  ARG   D C     1 ? 
ATOM   1791 O  O     . ARG   B 2 19  ? -8.126  -14.735 8.970   1.000 33.649 0 19  ARG   D O     1 ? 
ATOM   1792 C  CB    . ARG   B 2 19  ? -7.074  -17.042 10.798  1.000 39.757 0 19  ARG   D CB    1 ? 
ATOM   1793 C  CG    . ARG   B 2 19  ? -5.600  -17.413 10.712  1.000 46.393 0 19  ARG   D CG    1 ? 
ATOM   1794 C  CD    . ARG   B 2 19  ? -4.993  -17.745 12.061  1.000 50.402 0 19  ARG   D CD    1 ? 
ATOM   1795 N  NE    . ARG   B 2 19  ? -4.020  -18.828 11.955  1.000 55.024 0 19  ARG   D NE    1 ? 
ATOM   1796 C  CZ    . ARG   B 2 19  ? -2.718  -18.663 11.736  1.000 57.999 0 19  ARG   D CZ    1 ? 
ATOM   1797 N  NH1   . ARG   B 2 19  ? -2.226  -17.456 11.516  1.000 62.201 0 19  ARG   D NH1   1 ? 
ATOM   1798 N  NH2   . ARG   B 2 19  ? -1.913  -19.712 11.709  1.000 58.618 0 19  ARG   D NH2   1 ? 
ATOM   1799 N  N     . GLY   B 2 20  ? -6.134  -13.974 9.744   1.000 22.362 0 20  GLY   D N     1 ? 
ATOM   1800 C  CA    . GLY   B 2 20  ? -5.732  -13.332 8.502   1.000 18.255 0 20  GLY   D CA    1 ? 
ATOM   1801 C  C     . GLY   B 2 20  ? -4.786  -14.264 7.762   1.000 17.454 0 20  GLY   D C     1 ? 
ATOM   1802 O  O     . GLY   B 2 20  ? -4.294  -15.258 8.313   1.000 19.031 0 20  GLY   D O     1 ? 
ATOM   1803 N  N     . PHE   B 2 21  ? -4.558  -13.954 6.490   1.000 12.745 0 21  PHE   D N     1 ? 
ATOM   1804 C  CA    . PHE   B 2 21  ? -3.783  -14.811 5.609   1.000 11.963 0 21  PHE   D CA    1 ? 
ATOM   1805 C  C     . PHE   B 2 21  ? -2.605  -14.044 5.035   1.000 9.563  0 21  PHE   D C     1 ? 
ATOM   1806 O  O     . PHE   B 2 21  ? -2.698  -12.858 4.818   1.000 10.391 0 21  PHE   D O     1 ? 
ATOM   1807 C  CB    . PHE   B 2 21  ? -4.648  -15.337 4.467   1.000 12.564 0 21  PHE   D CB    1 ? 
ATOM   1808 C  CG    . PHE   B 2 21  ? -5.929  -15.982 4.917   1.000 15.177 0 21  PHE   D CG    1 ? 
ATOM   1809 C  CD1   . PHE   B 2 21  ? -5.898  -17.151 5.642   1.000 14.622 0 21  PHE   D CD1   1 ? 
ATOM   1810 C  CD2   . PHE   B 2 21  ? -7.142  -15.397 4.586   1.000 15.633 0 21  PHE   D CD2   1 ? 
ATOM   1811 C  CE1   . PHE   B 2 21  ? -7.083  -17.702 6.110   1.000 16.986 0 21  PHE   D CE1   1 ? 
ATOM   1812 C  CE2   . PHE   B 2 21  ? -8.334  -15.982 5.014   1.000 20.611 0 21  PHE   D CE2   1 ? 
ATOM   1813 C  CZ    . PHE   B 2 21  ? -8.287  -17.130 5.773   1.000 18.866 0 21  PHE   D CZ    1 ? 
ATOM   1814 N  N     . PRO   B 2 22  ? -1.464  -14.718 4.835   1.000 10.168 0 22  PRO   D N     1 ? 
ATOM   1815 C  CA    . PRO   B 2 22  ? -0.278  -14.084 4.284   1.000 8.799  0 22  PRO   D CA    1 ? 
ATOM   1816 C  C     . PRO   B 2 22  ? -0.378  -13.896 2.785   1.000 9.005  0 22  PRO   D C     1 ? 
ATOM   1817 O  O     . PRO   B 2 22  ? -1.247  -14.422 2.095   1.000 10.174 0 22  PRO   D O     1 ? 
ATOM   1818 C  CB    . PRO   B 2 22  ? 0.856   -15.048 4.659   1.000 10.078 0 22  PRO   D CB    1 ? 
ATOM   1819 C  CG    . PRO   B 2 22  ? 0.185   -16.402 4.599   1.000 10.666 0 22  PRO   D CG    1 ? 
ATOM   1820 C  CD    . PRO   B 2 22  ? -1.194  -16.117 5.147   1.000 10.801 0 22  PRO   D CD    1 ? 
ATOM   1821 N  N     . LEU   B 2 23  ? 0.539   -13.125 2.223   1.000 8.490  0 23  LEU   D N     1 ? 
ATOM   1822 C  CA    . LEU   B 2 23  ? 0.725   -13.031 0.793   1.000 8.196  0 23  LEU   D CA    1 ? 
ATOM   1823 C  C     . LEU   B 2 23  ? 1.475   -14.269 0.325   1.000 9.505  0 23  LEU   D C     1 ? 
ATOM   1824 O  O     . LEU   B 2 23  ? 2.546   -14.569 0.797   1.000 10.472 0 23  LEU   D O     1 ? 
ATOM   1825 C  CB    . LEU   B 2 23  ? 1.492   -11.715 0.503   1.000 9.286  0 23  LEU   D CB    1 ? 
ATOM   1826 C  CG    . LEU   B 2 23  ? 0.820   -10.429 0.951   1.000 9.178  0 23  LEU   D CG    1 ? 
ATOM   1827 C  CD1   . LEU   B 2 23  ? 1.820   -9.253  0.982   1.000 10.057 0 23  LEU   D CD1   1 ? 
ATOM   1828 C  CD2   . LEU   B 2 23  ? -0.350  -10.078 0.058   1.000 10.582 0 23  LEU   D CD2   1 ? 
ATOM   1829 N  N     . ARG   B 2 24  ? 0.948   -14.923 -0.686  1.000 8.450  0 24  ARG   D N     1 ? 
ATOM   1830 C  CA    . ARG   B 2 24  ? 1.616   -16.096 -1.230  1.000 8.779  0 24  ARG   D CA    1 ? 
ATOM   1831 C  C     . ARG   B 2 24  ? 2.771   -15.669 -2.131  1.000 8.629  0 24  ARG   D C     1 ? 
ATOM   1832 O  O     . ARG   B 2 24  ? 2.578   -14.880 -3.060  1.000 10.556 0 24  ARG   D O     1 ? 
ATOM   1833 C  CB    . ARG   B 2 24  ? 0.674   -16.983 -2.066  1.000 9.981  0 24  ARG   D CB    1 ? 
ATOM   1834 C  CG    . ARG   B 2 24  ? 1.350   -18.272 -2.540  1.000 11.376 0 24  ARG   D CG    1 ? 
ATOM   1835 C  CD    . ARG   B 2 24  ? 0.397   -19.212 -3.272  1.000 13.661 0 24  ARG   D CD    1 ? 
ATOM   1836 N  NE    . ARG   B 2 24  ? 1.133   -20.420 -3.650  1.000 15.817 0 24  ARG   D NE    1 ? 
ATOM   1837 C  CZ    . ARG   B 2 24  ? 0.867   -21.207 -4.684  1.000 21.954 0 24  ARG   D CZ    1 ? 
ATOM   1838 N  NH1   . ARG   B 2 24  ? -0.214  -21.026 -5.423  1.000 21.724 0 24  ARG   D NH1   1 ? 
ATOM   1839 N  NH2   . ARG   B 2 24  ? 1.693   -22.208 -4.945  1.000 21.833 0 24  ARG   D NH2   1 ? 
ATOM   1840 N  N     . LEU   B 2 25  ? 3.990   -16.146 -1.821  1.000 8.481  0 25  LEU   D N     1 ? 
ATOM   1841 C  CA    . LEU   B 2 25  ? 5.184   -15.783 -2.554  1.000 9.190  0 25  LEU   D CA    1 ? 
ATOM   1842 C  C     . LEU   B 2 25  ? 5.493   -16.798 -3.647  1.000 9.730  0 25  LEU   D C     1 ? 
ATOM   1843 O  O     . LEU   B 2 25  ? 5.477   -18.008 -3.358  1.000 10.493 0 25  LEU   D O     1 ? 
ATOM   1844 C  CB    . LEU   B 2 25  ? 6.340   -15.691 -1.564  1.000 9.910  0 25  LEU   D CB    1 ? 
ATOM   1845 C  CG    . LEU   B 2 25  ? 7.736   -15.441 -2.117  1.000 10.211 0 25  LEU   D CG    1 ? 
ATOM   1846 C  CD1   . LEU   B 2 25  ? 7.788   -14.080 -2.809  1.000 11.220 0 25  LEU   D CD1   1 ? 
ATOM   1847 C  CD2   . LEU   B 2 25  ? 8.736   -15.533 -0.963  1.000 9.983  0 25  LEU   D CD2   1 ? 
ATOM   1848 N  N     . GLN   B 2 26  ? 5.795   -16.326 -4.849  1.000 11.147 0 26  GLN   D N     1 ? 
ATOM   1849 C  CA    . GLN   B 2 26  ? 6.447   -17.059 -5.907  1.000 11.869 0 26  GLN   D CA    1 ? 
ATOM   1850 C  C     . GLN   B 2 26  ? 7.683   -16.279 -6.300  1.000 12.004 0 26  GLN   D C     1 ? 
ATOM   1851 O  O     . GLN   B 2 26  ? 7.716   -15.034 -6.268  1.000 12.957 0 26  GLN   D O     1 ? 
ATOM   1852 C  CB    . GLN   B 2 26  ? 5.502   -17.291 -7.063  1.000 13.055 0 26  GLN   D CB    1 ? 
ATOM   1853 C  CG    . GLN   B 2 26  ? 4.267   -18.074 -6.641  1.000 15.568 0 26  GLN   D CG    1 ? 
ATOM   1854 C  CD    . GLN   B 2 26  ? 4.519   -19.538 -6.468  1.000 21.249 0 26  GLN   D CD    1 ? 
ATOM   1855 O  OE1   . GLN   B 2 26  ? 4.548   -20.063 -5.362  1.000 24.407 0 26  GLN   D OE1   1 ? 
ATOM   1856 N  NE2   . GLN   B 2 26  ? 4.677   -20.209 -7.596  1.000 22.191 0 26  GLN   D NE2   1 ? 
ATOM   1857 N  N     . ALA   B 2 27  ? 8.731   -16.961 -6.700  1.000 11.620 0 27  ALA   D N     1 ? 
ATOM   1858 C  CA    . ALA   B 2 27  ? 9.903   -16.263 -7.197  1.000 12.258 0 27  ALA   D CA    1 ? 
ATOM   1859 C  C     . ALA   B 2 27  ? 10.404  -16.875 -8.492  1.000 13.587 0 27  ALA   D C     1 ? 
ATOM   1860 O  O     . ALA   B 2 27  ? 10.362  -18.098 -8.615  1.000 15.460 0 27  ALA   D O     1 ? 
ATOM   1861 C  CB    . ALA   B 2 27  ? 10.966  -16.268 -6.114  1.000 13.102 0 27  ALA   D CB    1 ? 
ATOM   1862 N  N     . THR   B 2 28  ? 10.896  -16.036 -9.385  1.000 12.864 0 28  THR   D N     1 ? 
ATOM   1863 C  CA    . THR   B 2 28  ? 11.611  -16.441 -10.573 1.000 13.480 0 28  THR   D CA    1 ? 
ATOM   1864 C  C     . THR   B 2 28  ? 13.103  -16.167 -10.477 1.000 14.087 0 28  THR   D C     1 ? 
ATOM   1865 O  O     . THR   B 2 28  ? 13.897  -16.721 -11.255 1.000 15.310 0 28  THR   D O     1 ? 
ATOM   1866 C  CB    . THR   B 2 28  ? 11.040  -15.826 -11.854 1.000 15.147 0 28  THR   D CB    1 ? 
ATOM   1867 O  OG1   . THR   B 2 28  ? 10.955  -14.391 -11.746 1.000 15.953 0 28  THR   D OG1   1 ? 
ATOM   1868 C  CG2   . THR   B 2 28  ? 9.690   -16.394 -12.236 1.000 19.207 0 28  THR   D CG2   1 ? 
ATOM   1869 N  N     . GLU   B 2 29  ? 13.505  -15.218 -9.625  1.000 11.754 0 29  GLU   D N     1 ? 
ATOM   1870 C  CA    . GLU   B 2 29  ? 14.914  -14.910 -9.453  1.000 11.264 0 29  GLU   D CA    1 ? 
ATOM   1871 C  C     . GLU   B 2 29  ? 15.192  -14.601 -7.989  1.000 11.408 0 29  GLU   D C     1 ? 
ATOM   1872 O  O     . GLU   B 2 29  ? 14.523  -13.747 -7.420  1.000 10.687 0 29  GLU   D O     1 ? 
ATOM   1873 C  CB    . GLU   B 2 29  ? 15.351  -13.731 -10.314 1.000 12.398 0 29  GLU   D CB    1 ? 
ATOM   1874 C  CG    . GLU   B 2 29  ? 16.821  -13.419 -10.240 1.000 15.071 0 29  GLU   D CG    1 ? 
ATOM   1875 C  CD    . GLU   B 2 29  ? 17.323  -12.110 -10.835 1.000 20.245 0 29  GLU   D CD    1 ? 
ATOM   1876 O  OE1   . GLU   B 2 29  ? 16.681  -11.552 -11.699 1.000 26.522 0 29  GLU   D OE1   1 ? 
ATOM   1877 O  OE2   . GLU   B 2 29  ? 18.377  -11.647 -10.371 1.000 32.794 0 29  GLU   D OE2   1 ? 
ATOM   1878 N  N     . VAL   B 2 30  ? 16.185  -15.239 -7.423  1.000 10.787 0 30  VAL   D N     1 ? 
ATOM   1879 C  CA    . VAL   B 2 30  ? 16.587  -15.169 -6.039  1.000 10.847 0 30  VAL   D CA    1 ? 
ATOM   1880 C  C     . VAL   B 2 30  ? 18.076  -14.850 -6.049  1.000 12.223 0 30  VAL   D C     1 ? 
ATOM   1881 O  O     . VAL   B 2 30  ? 18.795  -15.244 -6.987  1.000 14.392 0 30  VAL   D O     1 ? 
ATOM   1882 C  CB    . VAL   B 2 30  ? 16.251  -16.514 -5.329  1.000 12.574 0 30  VAL   D CB    1 ? 
ATOM   1883 C  CG1   . VAL   B 2 30  ? 16.883  -16.632 -3.966  1.000 14.472 0 30  VAL   D CG1   1 ? 
ATOM   1884 C  CG2   . VAL   B 2 30  ? 14.764  -16.742 -5.210  1.000 14.819 0 30  VAL   D CG2   1 ? 
ATOM   1885 N  N     . ARG   B 2 31  ? 18.564  -14.127 -5.060  1.000 11.230 0 31  ARG   D N     1 ? 
ATOM   1886 C  CA    . ARG   B 2 31  ? 20.004  -13.974 -4.877  1.000 12.586 0 31  ARG   D CA    1 ? 
ATOM   1887 C  C     . ARG   B 2 31  ? 20.302  -14.120 -3.390  1.000 12.543 0 31  ARG   D C     1 ? 
ATOM   1888 O  O     . ARG   B 2 31  ? 19.468  -13.898 -2.488  1.000 10.931 0 31  ARG   D O     1 ? 
ATOM   1889 C  CB    . ARG   B 2 31  ? 20.525  -12.642 -5.407  1.000 16.542 0 31  ARG   D CB    1 ? 
ATOM   1890 C  CG    . ARG   B 2 31  ? 20.293  -11.461 -4.506  1.000 24.855 0 31  ARG   D CG    1 ? 
ATOM   1891 C  CD    . ARG   B 2 31  ? 20.971  -10.185 -4.990  1.000 29.222 0 31  ARG   D CD    1 ? 
ATOM   1892 N  NE    . ARG   B 2 31  ? 20.971  -9.275  -3.855  1.000 31.760 0 31  ARG   D NE    1 ? 
ATOM   1893 C  CZ    . ARG   B 2 31  ? 21.167  -7.971  -3.926  1.000 38.681 0 31  ARG   D CZ    1 ? 
ATOM   1894 N  NH1   . ARG   B 2 31  ? 21.324  -7.398  -5.109  1.000 44.363 0 31  ARG   D NH1   1 ? 
ATOM   1895 N  NH2   . ARG   B 2 31  ? 21.150  -7.247  -2.816  1.000 38.114 0 31  ARG   D NH2   1 ? 
ATOM   1896 N  N     . ILE   B 2 32  ? 21.517  -14.584 -3.092  1.000 11.022 0 32  ILE   D N     1 ? 
ATOM   1897 C  CA    . ILE   B 2 32  ? 22.044  -14.643 -1.740  1.000 10.563 0 32  ILE   D CA    1 ? 
ATOM   1898 C  C     . ILE   B 2 32  ? 22.850  -13.382 -1.463  1.000 11.366 0 32  ILE   D C     1 ? 
ATOM   1899 O  O     . ILE   B 2 32  ? 23.736  -13.020 -2.231  1.000 13.772 0 32  ILE   D O     1 ? 
ATOM   1900 C  CB    . ILE   B 2 32  ? 22.898  -15.914 -1.570  1.000 11.375 0 32  ILE   D CB    1 ? 
ATOM   1901 C  CG1   . ILE   B 2 32  ? 22.129  -17.163 -1.989  1.000 11.433 0 32  ILE   D CG1   1 ? 
ATOM   1902 C  CG2   . ILE   B 2 32  ? 23.414  -16.022 -0.153  1.000 11.649 0 32  ILE   D CG2   1 ? 
ATOM   1903 C  CD1   . ILE   B 2 32  ? 20.888  -17.442 -1.181  1.000 13.028 0 32  ILE   D CD1   1 ? 
ATOM   1904 N  N     . CYS   B 2 33  ? 22.571  -12.716 -0.353  1.000 11.434 0 33  CYS   D N     1 ? 
ATOM   1905 C  CA    . CYS   B 2 33  ? 23.181  -11.442 -0.022  1.000 12.455 0 33  CYS   D CA    1 ? 
ATOM   1906 C  C     . CYS   B 2 33  ? 23.633  -11.466 1.431   1.000 12.729 0 33  CYS   D C     1 ? 
ATOM   1907 O  O     . CYS   B 2 33  ? 22.793  -11.433 2.347   1.000 13.796 0 33  CYS   D O     1 ? 
ATOM   1908 C  CB    . CYS   B 2 33  ? 22.206  -10.319 -0.251  1.000 15.424 0 33  CYS   D CB    1 ? 
ATOM   1909 S  SG    . CYS   B 2 33  ? 22.960  -8.705  0.081   1.000 24.136 0 33  CYS   D SG    1 ? 
ATOM   1910 N  N     . PRO   B 2 34  ? 24.940  -11.616 1.704   1.000 11.952 0 34  PRO   D N     1 ? 
ATOM   1911 C  CA    . PRO   B 2 34  ? 25.401  -11.603 3.090   1.000 12.827 0 34  PRO   D CA    1 ? 
ATOM   1912 C  C     . PRO   B 2 34  ? 25.000  -10.313 3.795   1.000 12.081 0 34  PRO   D C     1 ? 
ATOM   1913 O  O     . PRO   B 2 34  ? 25.043  -9.231  3.234   1.000 12.517 0 34  PRO   D O     1 ? 
ATOM   1914 C  CB    . PRO   B 2 34  ? 26.914  -11.816 2.987   1.000 14.038 0 34  PRO   D CB    1 ? 
ATOM   1915 C  CG    . PRO   B 2 34  ? 27.082  -12.517 1.663   1.000 14.121 0 34  PRO   D CG    1 ? 
ATOM   1916 C  CD    . PRO   B 2 34  ? 25.998  -12.006 0.757   1.000 14.442 0 34  PRO   D CD    1 ? 
ATOM   1917 N  N     . VAL   B 2 35  ? 24.541  -10.494 5.038   1.000 10.763 0 35  VAL   D N     1 ? 
ATOM   1918 C  CA    . VAL   B 2 35  ? 24.188  -9.438  5.960   1.000 10.839 0 35  VAL   D CA    1 ? 
ATOM   1919 C  C     . VAL   B 2 35  ? 24.994  -9.706  7.222   1.000 11.022 0 35  VAL   D C     1 ? 
ATOM   1920 O  O     . VAL   B 2 35  ? 25.127  -10.842 7.689   1.000 10.648 0 35  VAL   D O     1 ? 
ATOM   1921 C  CB    . VAL   B 2 35  ? 22.674  -9.455  6.254   1.000 10.426 0 35  VAL   D CB    1 ? 
ATOM   1922 C  CG1   . VAL   B 2 35  ? 22.253  -8.451  7.309   1.000 12.842 0 35  VAL   D CG1   1 ? 
ATOM   1923 C  CG2   . VAL   B 2 35  ? 21.845  -9.303  5.005   1.000 11.705 0 35  VAL   D CG2   1 ? 
ATOM   1924 N  N     . GLU   B 2 36  ? 25.530  -8.653  7.812   1.000 11.691 0 36  GLU   D N     1 ? 
ATOM   1925 C  CA    . GLU   B 2 36  ? 26.280  -8.813  9.031   1.000 12.667 0 36  GLU   D CA    1 ? 
ATOM   1926 C  C     . GLU   B 2 36  ? 25.385  -9.420  10.105  1.000 12.143 0 36  GLU   D C     1 ? 
ATOM   1927 O  O     . GLU   B 2 36  ? 24.293  -8.944  10.392  1.000 11.920 0 36  GLU   D O     1 ? 
ATOM   1928 C  CB    . GLU   B 2 36  ? 26.786  -7.460  9.533   1.000 16.581 0 36  GLU   D CB    1 ? 
ATOM   1929 C  CG    . GLU   B 2 36  ? 27.615  -7.536  10.799  1.000 23.137 0 36  GLU   D CG    1 ? 
ATOM   1930 C  CD    . GLU   B 2 36  ? 28.198  -6.220  11.286  1.000 32.176 0 36  GLU   D CD    1 ? 
ATOM   1931 O  OE1   . GLU   B 2 36  ? 28.043  -5.187  10.589  1.000 40.541 0 36  GLU   D OE1   1 ? 
ATOM   1932 O  OE2   . GLU   B 2 36  ? 28.802  -6.236  12.374  1.000 39.960 0 36  GLU   D OE2   1 ? 
ATOM   1933 N  N     . PHE   B 2 37  ? 25.832  -10.519 10.709  1.000 12.205 0 37  PHE   D N     1 ? 
ATOM   1934 C  CA    . PHE   B 2 37  ? 25.055  -11.232 11.704  1.000 12.949 0 37  PHE   D CA    1 ? 
ATOM   1935 C  C     . PHE   B 2 37  ? 24.898  -10.455 13.001  1.000 13.197 0 37  PHE   D C     1 ? 
ATOM   1936 O  O     . PHE   B 2 37  ? 25.871  -10.032 13.615  1.000 15.787 0 37  PHE   D O     1 ? 
ATOM   1937 C  CB    . PHE   B 2 37  ? 25.738  -12.567 11.982  1.000 13.197 0 37  PHE   D CB    1 ? 
ATOM   1938 C  CG    . PHE   B 2 37  ? 25.081  -13.493 12.970  1.000 15.315 0 37  PHE   D CG    1 ? 
ATOM   1939 C  CD1   . PHE   B 2 37  ? 23.738  -13.821 12.909  1.000 14.397 0 37  PHE   D CD1   1 ? 
ATOM   1940 C  CD2   . PHE   B 2 37  ? 25.866  -14.161 13.909  1.000 19.164 0 37  PHE   D CD2   1 ? 
ATOM   1941 C  CE1   . PHE   B 2 37  ? 23.165  -14.695 13.818  1.000 16.644 0 37  PHE   D CE1   1 ? 
ATOM   1942 C  CE2   . PHE   B 2 37  ? 25.310  -15.063 14.798  1.000 19.457 0 37  PHE   D CE2   1 ? 
ATOM   1943 C  CZ    . PHE   B 2 37  ? 23.955  -15.331 14.748  1.000 17.447 0 37  PHE   D CZ    1 ? 
ATOM   1944 N  N     . ASN   B 2 38  ? 23.648  -10.229 13.380  1.000 12.260 0 38  ASN   D N     1 ? 
ATOM   1945 C  CA    . ASN   B 2 38  ? 23.296  -9.521  14.598  1.000 11.304 0 38  ASN   D CA    1 ? 
ATOM   1946 C  C     . ASN   B 2 38  ? 22.479  -10.470 15.472  1.000 13.424 0 38  ASN   D C     1 ? 
ATOM   1947 O  O     . ASN   B 2 38  ? 21.258  -10.555 15.313  1.000 11.565 0 38  ASN   D O     1 ? 
ATOM   1948 C  CB    . ASN   B 2 38  ? 22.525  -8.238  14.259  1.000 12.041 0 38  ASN   D CB    1 ? 
ATOM   1949 C  CG    . ASN   B 2 38  ? 22.196  -7.416  15.481  1.000 12.708 0 38  ASN   D CG    1 ? 
ATOM   1950 O  OD1   . ASN   B 2 38  ? 22.149  -7.940  16.601  1.000 13.427 0 38  ASN   D OD1   1 ? 
ATOM   1951 N  ND2   . ASN   B 2 38  ? 21.945  -6.122  15.260  1.000 12.400 0 38  ASN   D ND2   1 ? 
ATOM   1952 N  N     . PRO   B 2 39  ? 23.118  -11.341 16.290  1.000 13.211 0 39  PRO   D N     1 ? 
ATOM   1953 C  CA    . PRO   B 2 39  ? 22.376  -12.386 17.011  1.000 14.439 0 39  PRO   D CA    1 ? 
ATOM   1954 C  C     . PRO   B 2 39  ? 21.369  -11.819 18.003  1.000 13.805 0 39  PRO   D C     1 ? 
ATOM   1955 O  O     . PRO   B 2 39  ? 20.299  -12.400 18.176  1.000 14.892 0 39  PRO   D O     1 ? 
ATOM   1956 C  CB    . PRO   B 2 39  ? 23.458  -13.197 17.720  1.000 15.435 0 39  PRO   D CB    1 ? 
ATOM   1957 C  CG    . PRO   B 2 39  ? 24.669  -12.286 17.763  1.000 15.819 0 39  PRO   D CG    1 ? 
ATOM   1958 C  CD    . PRO   B 2 39  ? 24.577  -11.437 16.506  1.000 16.180 0 39  PRO   D CD    1 ? 
ATOM   1959 N  N     . ASN   B 2 40  ? 21.630  -10.610 18.511  1.000 12.618 0 40  ASN   D N     1 ? 
ATOM   1960 C  CA    . ASN   B 2 40  ? 20.695  -9.968  19.430  1.000 14.457 0 40  ASN   D CA    1 ? 
ATOM   1961 C  C     . ASN   B 2 40  ? 19.404  -9.672  18.673  1.000 12.645 0 40  ASN   D C     1 ? 
ATOM   1962 O  O     . ASN   B 2 40  ? 18.298  -10.017 19.134  1.000 12.186 0 40  ASN   D O     1 ? 
ATOM   1963 C  CB    . ASN   B 2 40  ? 21.332  -8.740  20.071  1.000 19.074 0 40  ASN   D CB    1 ? 
ATOM   1964 C  CG    . ASN   B 2 40  ? 22.320  -9.116  21.163  1.000 28.416 0 40  ASN   D CG    1 ? 
ATOM   1965 O  OD1   . ASN   B 2 40  ? 22.345  -10.251 21.646  1.000 34.502 0 40  ASN   D OD1   1 ? 
ATOM   1966 N  ND2   . ASN   B 2 40  ? 23.131  -8.156  21.572  1.000 36.204 0 40  ASN   D ND2   1 ? 
ATOM   1967 N  N     . PHE   B 2 41  ? 19.537  -9.119  17.457  1.000 10.676 0 41  PHE   D N     1 ? 
ATOM   1968 C  CA    . PHE   B 2 41  ? 18.380  -8.833  16.624  1.000 10.199 0 41  PHE   D CA    1 ? 
ATOM   1969 C  C     . PHE   B 2 41  ? 17.630  -10.115 16.255  1.000 10.320 0 41  PHE   D C     1 ? 
ATOM   1970 O  O     . PHE   B 2 41  ? 16.414  -10.185 16.378  1.000 10.359 0 41  PHE   D O     1 ? 
ATOM   1971 C  CB    . PHE   B 2 41  ? 18.823  -8.128  15.341  1.000 9.275  0 41  PHE   D CB    1 ? 
ATOM   1972 C  CG    . PHE   B 2 41  ? 17.688  -7.900  14.379  1.000 8.893  0 41  PHE   D CG    1 ? 
ATOM   1973 C  CD1   . PHE   B 2 41  ? 16.592  -7.095  14.714  1.000 7.947  0 41  PHE   D CD1   1 ? 
ATOM   1974 C  CD2   . PHE   B 2 41  ? 17.704  -8.445  13.097  1.000 8.630  0 41  PHE   D CD2   1 ? 
ATOM   1975 C  CE1   . PHE   B 2 41  ? 15.593  -6.815  13.805  1.000 9.240  0 41  PHE   D CE1   1 ? 
ATOM   1976 C  CE2   . PHE   B 2 41  ? 16.709  -8.152  12.195  1.000 10.188 0 41  PHE   D CE2   1 ? 
ATOM   1977 C  CZ    . PHE   B 2 41  ? 15.632  -7.358  12.567  1.000 8.773  0 41  PHE   D CZ    1 ? 
ATOM   1978 N  N     . VAL   B 2 42  ? 18.337  -11.137 15.800  1.000 10.859 0 42  VAL   D N     1 ? 
ATOM   1979 C  CA    . VAL   B 2 42  ? 17.654  -12.319 15.337  1.000 11.178 0 42  VAL   D CA    1 ? 
ATOM   1980 C  C     . VAL   B 2 42  ? 16.868  -12.940 16.492  1.000 11.072 0 42  VAL   D C     1 ? 
ATOM   1981 O  O     . VAL   B 2 42  ? 15.737  -13.362 16.300  1.000 10.815 0 42  VAL   D O     1 ? 
ATOM   1982 C  CB    . VAL   B 2 42  ? 18.611  -13.335 14.712  1.000 11.448 0 42  VAL   D CB    1 ? 
ATOM   1983 C  CG1   . VAL   B 2 42  ? 17.903  -14.633 14.382  1.000 11.908 0 42  VAL   D CG1   1 ? 
ATOM   1984 C  CG2   . VAL   B 2 42  ? 19.313  -12.790 13.481  1.000 12.225 0 42  VAL   D CG2   1 ? 
ATOM   1985 N  N     . ALA   B 2 43  ? 17.468  -13.001 17.676  1.000 11.719 0 43  ALA   D N     1 ? 
ATOM   1986 C  CA    . ALA   B 2 43  ? 16.796  -13.561 18.847  1.000 11.367 0 43  ALA   D CA    1 ? 
ATOM   1987 C  C     . ALA   B 2 43  ? 15.522  -12.778 19.166  1.000 11.687 0 43  ALA   D C     1 ? 
ATOM   1988 O  O     . ALA   B 2 43  ? 14.503  -13.396 19.496  1.000 13.793 0 43  ALA   D O     1 ? 
ATOM   1989 C  CB    . ALA   B 2 43  ? 17.714  -13.572 20.046  1.000 11.717 0 43  ALA   D CB    1 ? 
ATOM   1990 N  N     . ARG   B 2 44  ? 15.561  -11.446 19.070  1.000 11.237 0 44  ARG   D N     1 ? 
ATOM   1991 C  CA    . ARG   B 2 44  ? 14.382  -10.609 19.254  1.000 12.465 0 44  ARG   D CA    1 ? 
ATOM   1992 C  C     . ARG   B 2 44  ? 13.285  -10.924 18.237  1.000 12.991 0 44  ARG   D C     1 ? 
ATOM   1993 O  O     . ARG   B 2 44  ? 12.078  -10.745 18.489  1.000 13.214 0 44  ARG   D O     1 ? 
ATOM   1994 C  CB    . ARG   B 2 44  ? 14.759  -9.117  19.050  1.000 14.233 0 44  ARG   D CB    1 ? 
ATOM   1995 C  CG    . ARG   B 2 44  ? 15.486  -8.502  20.222  1.000 15.863 0 44  ARG   D CG    1 ? 
ATOM   1996 C  CD    . ARG   B 2 44  ? 15.516  -7.011  20.073  1.000 13.941 0 44  ARG   D CD    1 ? 
ATOM   1997 N  NE    . ARG   B 2 44  ? 14.185  -6.471  20.302  1.000 13.639 0 44  ARG   D NE    1 ? 
ATOM   1998 C  CZ    . ARG   B 2 44  ? 13.410  -5.869  19.393  1.000 11.848 0 44  ARG   D CZ    1 ? 
ATOM   1999 N  NH1   . ARG   B 2 44  ? 13.863  -5.505  18.213  1.000 11.311 0 44  ARG   D NH1   1 ? 
ATOM   2000 N  NH2   . ARG   B 2 44  ? 12.197  -5.492  19.706  1.000 12.383 0 44  ARG   D NH2   1 ? 
ATOM   2001 N  N     . MET   B 2 45  ? 13.689  -11.284 17.023  1.000 11.433 0 45  MET   D N     1 ? 
ATOM   2002 C  CA    . MET   B 2 45  ? 12.750  -11.490 15.938  1.000 11.036 0 45  MET   D CA    1 ? 
ATOM   2003 C  C     . MET   B 2 45  ? 12.083  -12.871 16.041  1.000 11.296 0 45  MET   D C     1 ? 
ATOM   2004 O  O     . MET   B 2 45  ? 10.990  -13.023 15.516  1.000 11.486 0 45  MET   D O     1 ? 
ATOM   2005 C  CB    . MET   B 2 45  ? 13.447  -11.305 14.584  1.000 11.864 0 45  MET   D CB    1 ? 
ATOM   2006 C  CG    . MET   B 2 45  ? 13.831  -9.830  14.216  1.000 11.503 0 45  MET   D CG    1 ? 
ATOM   2007 S  SD    . MET   B 2 45  ? 12.432  -8.679  14.148  1.000 14.118 0 45  MET   D SD    1 ? 
ATOM   2008 C  CE    . MET   B 2 45  ? 12.561  -7.946  15.751  1.000 12.560 0 45  MET   D CE    1 ? 
ATOM   2009 N  N     . ILE   B 2 46  ? 12.733  -13.873 16.634  1.000 12.039 0 46  ILE   D N     1 ? 
ATOM   2010 C  CA    . ILE   B 2 46  ? 12.203  -15.239 16.617  1.000 13.312 0 46  ILE   D CA    1 ? 
ATOM   2011 C  C     . ILE   B 2 46  ? 10.740  -15.281 17.069  1.000 13.330 0 46  ILE   D C     1 ? 
ATOM   2012 O  O     . ILE   B 2 46  ? 9.895   -15.892 16.394  1.000 14.318 0 46  ILE   D O     1 ? 
ATOM   2013 C  CB    . ILE   B 2 46  ? 13.115  -16.182 17.429  1.000 13.785 0 46  ILE   D CB    1 ? 
ATOM   2014 C  CG1   . ILE   B 2 46  ? 14.474  -16.359 16.745  1.000 14.887 0 46  ILE   D CG1   1 ? 
ATOM   2015 C  CG2   . ILE   B 2 46  ? 12.485  -17.531 17.644  1.000 13.943 0 46  ILE   D CG2   1 ? 
ATOM   2016 C  CD1   . ILE   B 2 46  ? 14.423  -16.877 15.336  1.000 14.505 0 46  ILE   D CD1   1 ? 
ATOM   2017 N  N     . PRO   B 2 47  ? 10.339  -14.727 18.234  1.000 13.175 0 47  PRO   D N     1 ? 
ATOM   2018 C  CA    . PRO   B 2 47  ? 8.938   -14.812 18.665  1.000 13.555 0 47  PRO   D CA    1 ? 
ATOM   2019 C  C     . PRO   B 2 47  ? 7.961   -13.992 17.835  1.000 14.047 0 47  PRO   D C     1 ? 
ATOM   2020 O  O     . PRO   B 2 47  ? 6.743   -14.173 17.973  1.000 14.130 0 47  PRO   D O     1 ? 
ATOM   2021 C  CB    . PRO   B 2 47  ? 8.975   -14.363 20.136  1.000 14.705 0 47  PRO   D CB    1 ? 
ATOM   2022 C  CG    . PRO   B 2 47  ? 10.306  -13.699 20.349  1.000 17.119 0 47  PRO   D CG    1 ? 
ATOM   2023 C  CD    . PRO   B 2 47  ? 11.234  -14.184 19.270  1.000 14.595 0 47  PRO   D CD    1 ? 
ATOM   2024 N  N     . LYS   B 2 48  ? 8.473   -13.129 16.958  1.000 12.732 0 48  LYS   D N     1 ? 
ATOM   2025 C  CA    . LYS   B 2 48  ? 7.640   -12.267 16.138  1.000 12.426 0 48  LYS   D CA    1 ? 
ATOM   2026 C  C     . LYS   B 2 48  ? 7.346   -12.877 14.767  1.000 11.553 0 48  LYS   D C     1 ? 
ATOM   2027 O  O     . LYS   B 2 48  ? 6.441   -12.428 14.071  1.000 12.223 0 48  LYS   D O     1 ? 
ATOM   2028 C  CB    . LYS   B 2 48  ? 8.321   -10.914 15.995  1.000 14.871 0 48  LYS   D CB    1 ? 
ATOM   2029 C  CG    . LYS   B 2 48  ? 8.588   -10.292 17.357  1.000 17.853 0 48  LYS   D CG    1 ? 
ATOM   2030 C  CD    . LYS   B 2 48  ? 9.132   -8.916  17.280  1.000 20.229 0 48  LYS   D CD    1 ? 
ATOM   2031 C  CE    . LYS   B 2 48  ? 9.559   -8.318  18.602  1.000 22.248 0 48  LYS   D CE    1 ? 
ATOM   2032 N  NZ    . LYS   B 2 48  ? 8.519   -8.345  19.663  1.000 25.078 0 48  LYS   D NZ    1 ? 
ATOM   2033 N  N     . VAL   B 2 49  ? 8.066   -13.922 14.381  1.000 11.361 0 49  VAL   D N     1 ? 
ATOM   2034 C  CA    . VAL   B 2 49  ? 7.851   -14.542 13.092  1.000 11.524 0 49  VAL   D CA    1 ? 
ATOM   2035 C  C     . VAL   B 2 49  ? 6.558   -15.350 13.146  1.000 10.544 0 49  VAL   D C     1 ? 
ATOM   2036 O  O     . VAL   B 2 49  ? 6.324   -16.161 14.070  1.000 12.710 0 49  VAL   D O     1 ? 
ATOM   2037 C  CB    . VAL   B 2 49  ? 9.059   -15.424 12.696  1.000 12.007 0 49  VAL   D CB    1 ? 
ATOM   2038 C  CG1   . VAL   B 2 49  ? 8.795   -16.259 11.452  1.000 13.838 0 49  VAL   D CG1   1 ? 
ATOM   2039 C  CG2   . VAL   B 2 49  ? 10.292  -14.563 12.487  1.000 13.179 0 49  VAL   D CG2   1 ? 
ATOM   2040 N  N     . GLU   B 2 50  ? 5.788   -15.179 12.080  1.000 9.335  0 50  GLU   D N     1 ? 
ATOM   2041 C  CA    . GLU   B 2 50  ? 4.609   -15.987 11.822  1.000 9.794  0 50  GLU   D CA    1 ? 
ATOM   2042 C  C     . GLU   B 2 50  ? 5.104   -17.237 11.126  1.000 10.042 0 50  GLU   D C     1 ? 
ATOM   2043 O  O     . GLU   B 2 50  ? 5.451   -17.195 9.953   1.000 10.056 0 50  GLU   D O     1 ? 
ATOM   2044 C  CB    . GLU   B 2 50  ? 3.558   -15.270 10.978  1.000 10.621 0 50  GLU   D CB    1 ? 
ATOM   2045 C  CG    . GLU   B 2 50  ? 2.850   -14.140 11.719  1.000 12.290 0 50  GLU   D CG    1 ? 
ATOM   2046 C  CD    . GLU   B 2 50  ? 1.744   -13.433 10.953  1.000 13.695 0 50  GLU   D CD    1 ? 
ATOM   2047 O  OE1   . GLU   B 2 50  ? 1.501   -13.776 9.793   1.000 14.951 0 50  GLU   D OE1   1 ? 
ATOM   2048 O  OE2   . GLU   B 2 50  ? 1.120   -12.544 11.537  1.000 16.421 0 50  GLU   D OE2   1 ? 
ATOM   2049 N  N     . TRP   B 2 51  ? 5.214   -18.360 11.829  1.000 11.174 0 51  TRP   D N     1 ? 
ATOM   2050 C  CA    . TRP   B 2 51  ? 6.012   -19.474 11.361  1.000 11.563 0 51  TRP   D CA    1 ? 
ATOM   2051 C  C     . TRP   B 2 51  ? 5.355   -20.188 10.183  1.000 10.956 0 51  TRP   D C     1 ? 
ATOM   2052 O  O     . TRP   B 2 51  ? 6.045   -20.550 9.236   1.000 11.902 0 51  TRP   D O     1 ? 
ATOM   2053 C  CB    . TRP   B 2 51  ? 6.371   -20.445 12.493  1.000 12.735 0 51  TRP   D CB    1 ? 
ATOM   2054 C  CG    . TRP   B 2 51  ? 7.794   -20.889 12.349  1.000 16.829 0 51  TRP   D CG    1 ? 
ATOM   2055 C  CD1   . TRP   B 2 51  ? 8.242   -21.947 11.611  1.000 17.945 0 51  TRP   D CD1   1 ? 
ATOM   2056 C  CD2   . TRP   B 2 51  ? 8.950   -20.295 12.944  1.000 15.148 0 51  TRP   D CD2   1 ? 
ATOM   2057 N  NE1   . TRP   B 2 51  ? 9.598   -22.023 11.700  1.000 16.974 0 51  TRP   D NE1   1 ? 
ATOM   2058 C  CE2   . TRP   B 2 51  ? 10.067  -21.018 12.477  1.000 15.941 0 51  TRP   D CE2   1 ? 
ATOM   2059 C  CE3   . TRP   B 2 51  ? 9.187   -19.178 13.754  1.000 17.416 0 51  TRP   D CE3   1 ? 
ATOM   2060 C  CZ2   . TRP   B 2 51  ? 11.357  -20.745 12.894  1.000 16.085 0 51  TRP   D CZ2   1 ? 
ATOM   2061 C  CZ3   . TRP   B 2 51  ? 10.469  -18.894 14.151  1.000 18.834 0 51  TRP   D CZ3   1 ? 
ATOM   2062 C  CH2   . TRP   B 2 51  ? 11.539  -19.665 13.716  1.000 16.371 0 51  TRP   D CH2   1 ? 
ATOM   2063 N  N     . SER   B 2 52  ? 4.029   -20.333 10.155  1.000 11.975 0 52  SER   D N     1 ? 
ATOM   2064 C  CA    . SER   B 2 52  ? 3.430   -20.997 9.005   1.000 12.925 0 52  SER   D CA    1 ? 
ATOM   2065 C  C     . SER   B 2 52  ? 3.665   -20.240 7.687   1.000 10.605 0 52  SER   D C     1 ? 
ATOM   2066 O  O     . SER   B 2 52  ? 3.966   -20.804 6.630   1.000 12.020 0 52  SER   D O     1 ? 
ATOM   2067 C  CB    . SER   B 2 52  ? 1.945   -21.233 9.219   1.000 16.121 0 52  SER   D CB    1 ? 
ATOM   2068 O  OG    . SER   B 2 52  ? 1.310   -20.007 9.497   1.000 21.087 0 52  SER   D OG    1 ? 
ATOM   2069 N  N     . ALA   B 2 53  ? 3.607   -18.897 7.766   1.000 9.112  0 53  ALA   D N     1 ? 
ATOM   2070 C  CA    . ALA   B 2 53  ? 3.826   -18.102 6.558   1.000 9.468  0 53  ALA   D CA    1 ? 
ATOM   2071 C  C     . ALA   B 2 53  ? 5.297   -18.167 6.117   1.000 8.273  0 53  ALA   D C     1 ? 
ATOM   2072 O  O     . ALA   B 2 53  ? 5.579   -18.186 4.929   1.000 8.885  0 53  ALA   D O     1 ? 
ATOM   2073 C  CB    . ALA   B 2 53  ? 3.432   -16.670 6.817   1.000 10.331 0 53  ALA   D CB    1 ? 
ATOM   2074 N  N     . PHE   B 2 54  ? 6.212   -18.118 7.074   1.000 7.842  0 54  PHE   D N     1 ? 
ATOM   2075 C  CA    . PHE   B 2 54  ? 7.647   -18.277 6.815   1.000 8.053  0 54  PHE   D CA    1 ? 
ATOM   2076 C  C     . PHE   B 2 54  ? 7.919   -19.633 6.173   1.000 7.932  0 54  PHE   D C     1 ? 
ATOM   2077 O  O     . PHE   B 2 54  ? 8.598   -19.667 5.129   1.000 7.831  0 54  PHE   D O     1 ? 
ATOM   2078 C  CB    . PHE   B 2 54  ? 8.441   -18.094 8.117   1.000 8.272  0 54  PHE   D CB    1 ? 
ATOM   2079 C  CG    . PHE   B 2 54  ? 9.874   -18.521 8.024   1.000 8.786  0 54  PHE   D CG    1 ? 
ATOM   2080 C  CD1   . PHE   B 2 54  ? 10.783  -17.892 7.189   1.000 9.144  0 54  PHE   D CD1   1 ? 
ATOM   2081 C  CD2   . PHE   B 2 54  ? 10.277  -19.627 8.737   1.000 9.518  0 54  PHE   D CD2   1 ? 
ATOM   2082 C  CE1   . PHE   B 2 54  ? 12.114  -18.286 7.169   1.000 10.009 0 54  PHE   D CE1   1 ? 
ATOM   2083 C  CE2   . PHE   B 2 54  ? 11.604  -20.028 8.705   1.000 9.890  0 54  PHE   D CE2   1 ? 
ATOM   2084 C  CZ    . PHE   B 2 54  ? 12.514  -19.375 7.898   1.000 11.421 0 54  PHE   D CZ    1 ? 
ATOM   2085 N  N     . LEU   B 2 55  ? 7.357   -20.722 6.702   1.000 8.901  0 55  LEU   D N     1 ? 
ATOM   2086 C  CA    . LEU   B 2 55  ? 7.634   -22.044 6.137   1.000 10.010 0 55  LEU   D CA    1 ? 
ATOM   2087 C  C     . LEU   B 2 55  ? 7.152   -22.151 4.687   1.000 10.153 0 55  LEU   D C     1 ? 
ATOM   2088 O  O     . LEU   B 2 55  ? 7.826   -22.715 3.809   1.000 10.597 0 55  LEU   D O     1 ? 
ATOM   2089 C  CB    . LEU   B 2 55  ? 7.010   -23.158 6.992   1.000 10.732 0 55  LEU   D CB    1 ? 
ATOM   2090 C  CG    . LEU   B 2 55  ? 7.630   -23.329 8.369   1.000 11.978 0 55  LEU   D CG    1 ? 
ATOM   2091 C  CD1   . LEU   B 2 55  ? 6.790   -24.293 9.217   1.000 14.237 0 55  LEU   D CD1   1 ? 
ATOM   2092 C  CD2   . LEU   B 2 55  ? 9.070   -23.798 8.277   1.000 13.584 0 55  LEU   D CD2   1 ? 
ATOM   2093 N  N     . GLU   B 2 56  ? 5.948   -21.637 4.397   1.000 10.078 0 56  GLU   D N     1 ? 
ATOM   2094 C  CA    . GLU   B 2 56  ? 5.365   -21.681 3.071   1.000 11.581 0 56  GLU   D CA    1 ? 
ATOM   2095 C  C     . GLU   B 2 56  ? 6.291   -20.939 2.108   1.000 10.302 0 56  GLU   D C     1 ? 
ATOM   2096 O  O     . GLU   B 2 56  ? 6.560   -21.408 0.998   1.000 10.485 0 56  GLU   D O     1 ? 
ATOM   2097 C  CB    . GLU   B 2 56  ? 3.967   -21.044 3.137   1.000 14.743 0 56  GLU   D CB    1 ? 
ATOM   2098 C  CG    . GLU   B 2 56  ? 3.162   -20.932 1.860   1.000 21.970 0 56  GLU   D CG    1 ? 
ATOM   2099 C  CD    . GLU   B 2 56  ? 1.904   -20.052 1.919   1.000 27.358 0 56  GLU   D CD    1 ? 
ATOM   2100 O  OE1   . GLU   B 2 56  ? 1.530   -19.516 3.036   1.000 25.406 0 56  GLU   D OE1   1 ? 
ATOM   2101 O  OE2   . GLU   B 2 56  ? 1.284   -19.890 0.817   1.000 32.178 0 56  GLU   D OE2   1 ? 
ATOM   2102 N  N     . ALA   B 2 57  ? 6.685   -19.711 2.474   1.000 9.387  0 57  ALA   D N     1 ? 
ATOM   2103 C  CA    . ALA   B 2 57  ? 7.513   -18.889 1.619   1.000 8.750  0 57  ALA   D CA    1 ? 
ATOM   2104 C  C     . ALA   B 2 57  ? 8.875   -19.551 1.383   1.000 8.243  0 57  ALA   D C     1 ? 
ATOM   2105 O  O     . ALA   B 2 57  ? 9.350   -19.564 0.263   1.000 8.598  0 57  ALA   D O     1 ? 
ATOM   2106 C  CB    . ALA   B 2 57  ? 7.666   -17.495 2.198   1.000 9.440  0 57  ALA   D CB    1 ? 
ATOM   2107 N  N     . ALA   B 2 58  ? 9.489   -20.042 2.466   1.000 9.383  0 58  ALA   D N     1 ? 
ATOM   2108 C  CA    . ALA   B 2 58  ? 10.789  -20.715 2.356   1.000 9.189  0 58  ALA   D CA    1 ? 
ATOM   2109 C  C     . ALA   B 2 58  ? 10.677  -21.926 1.413   1.000 10.577 0 58  ALA   D C     1 ? 
ATOM   2110 O  O     . ALA   B 2 58  ? 11.594  -22.160 0.583   1.000 10.525 0 58  ALA   D O     1 ? 
ATOM   2111 C  CB    . ALA   B 2 58  ? 11.279  -21.083 3.731   1.000 9.499  0 58  ALA   D CB    1 ? 
ATOM   2112 N  N     . ASP   B 2 59  ? 9.593   -22.698 1.529   1.000 10.931 0 59  ASP   D N     1 ? 
ATOM   2113 C  CA    . ASP   B 2 59  ? 9.445   -23.861 0.659   1.000 12.116 0 59  ASP   D CA    1 ? 
ATOM   2114 C  C     . ASP   B 2 59  ? 9.336   -23.420 -0.801  1.000 11.416 0 59  ASP   D C     1 ? 
ATOM   2115 O  O     . ASP   B 2 59  ? 9.924   -23.989 -1.717  1.000 12.220 0 59  ASP   D O     1 ? 
ATOM   2116 C  CB    . ASP   B 2 59  ? 8.245   -24.720 1.062   1.000 15.720 0 59  ASP   D CB    1 ? 
ATOM   2117 C  CG    . ASP   B 2 59  ? 8.422   -26.136 0.532   1.000 23.051 0 59  ASP   D CG    1 ? 
ATOM   2118 O  OD1   . ASP   B 2 59  ? 9.352   -26.820 0.987   1.000 27.595 0 59  ASP   D OD1   1 ? 
ATOM   2119 O  OD2   . ASP   B 2 59  ? 7.695   -26.484 -0.361  1.000 27.317 0 59  ASP   D OD2   1 ? 
ATOM   2120 N  N     . ASN   B 2 60  ? 8.655   -22.295 -1.051  1.000 10.793 0 60  ASN   D N     1 ? 
ATOM   2121 C  CA    . ASN   B 2 60  ? 8.489   -21.819 -2.406  1.000 11.311 0 60  ASN   D CA    1 ? 
ATOM   2122 C  C     . ASN   B 2 60  ? 9.807   -21.313 -2.996  1.000 12.405 0 60  ASN   D C     1 ? 
ATOM   2123 O  O     . ASN   B 2 60  ? 9.999   -21.336 -4.199  1.000 16.712 0 60  ASN   D O     1 ? 
ATOM   2124 C  CB    . ASN   B 2 60  ? 7.408   -20.717 -2.436  1.000 12.439 0 60  ASN   D CB    1 ? 
ATOM   2125 C  CG    . ASN   B 2 60  ? 6.012   -21.219 -2.074  1.000 16.311 0 60  ASN   D CG    1 ? 
ATOM   2126 O  OD1   . ASN   B 2 60  ? 5.759   -22.430 -1.976  1.000 17.358 0 60  ASN   D OD1   1 ? 
ATOM   2127 N  ND2   . ASN   B 2 60  ? 5.057   -20.311 -1.863  1.000 15.456 0 60  ASN   D ND2   1 ? 
ATOM   2128 N  N     . LEU   B 2 61  ? 10.765  -20.927 -2.165  1.000 10.856 0 61  LEU   D N     1 ? 
ATOM   2129 C  CA    . LEU   B 2 61  ? 12.097  -20.559 -2.607  1.000 12.230 0 61  LEU   D CA    1 ? 
ATOM   2130 C  C     . LEU   B 2 61  ? 13.053  -21.756 -2.619  1.000 11.342 0 61  LEU   D C     1 ? 
ATOM   2131 O  O     . LEU   B 2 61  ? 14.254  -21.542 -2.857  1.000 12.812 0 61  LEU   D O     1 ? 
ATOM   2132 C  CB    . LEU   B 2 61  ? 12.636  -19.467 -1.684  1.000 12.148 0 61  LEU   D CB    1 ? 
ATOM   2133 C  CG    . LEU   B 2 61  ? 11.865  -18.131 -1.667  1.000 12.015 0 61  LEU   D CG    1 ? 
ATOM   2134 C  CD1   . LEU   B 2 61  ? 12.635  -17.055 -0.938  1.000 13.374 0 61  LEU   D CD1   1 ? 
ATOM   2135 C  CD2   . LEU   B 2 61  ? 11.492  -17.652 -3.052  1.000 12.540 0 61  LEU   D CD2   1 ? 
ATOM   2136 N  N     . ARG   B 2 62  ? 12.543  -22.970 -2.419  1.000 12.708 0 62  ARG   D N     1 ? 
ATOM   2137 C  CA    . ARG   B 2 62  ? 13.343  -24.202 -2.475  1.000 13.393 0 62  ARG   D CA    1 ? 
ATOM   2138 C  C     . ARG   B 2 62  ? 14.432  -24.193 -1.405  1.000 12.007 0 62  ARG   D C     1 ? 
ATOM   2139 O  O     . ARG   B 2 62  ? 15.495  -24.837 -1.553  1.000 13.300 0 62  ARG   D O     1 ? 
ATOM   2140 C  CB    . ARG   B 2 62  ? 13.958  -24.452 -3.862  1.000 16.777 0 62  ARG   D CB    1 ? 
ATOM   2141 C  CG    . ARG   B 2 62  ? 12.919  -24.526 -4.978  1.000 23.665 0 62  ARG   D CG    1 ? 
ATOM   2142 C  CD    . ARG   B 2 62  ? 13.453  -24.903 -6.352  1.000 31.167 0 62  ARG   D CD    1 ? 
ATOM   2143 N  NE    . ARG   B 2 62  ? 13.428  -23.767 -7.258  1.000 38.535 0 62  ARG   D NE    1 ? 
ATOM   2144 C  CZ    . ARG   B 2 62  ? 13.638  -23.845 -8.569  1.000 50.266 0 62  ARG   D CZ    1 ? 
ATOM   2145 N  NH1   . ARG   B 2 62  ? 14.041  -24.985 -9.102  1.000 53.302 0 62  ARG   D NH1   1 ? 
ATOM   2146 N  NH2   . ARG   B 2 62  ? 13.459  -22.782 -9.337  1.000 51.194 0 62  ARG   D NH2   1 ? 
ATOM   2147 N  N     . LEU   B 2 63  ? 14.146  -23.580 -0.259  1.000 10.327 0 63  LEU   D N     1 ? 
ATOM   2148 C  CA    . LEU   B 2 63  ? 14.995  -23.680 0.909   1.000 9.724  0 63  LEU   D CA    1 ? 
ATOM   2149 C  C     . LEU   B 2 63  ? 14.739  -25.026 1.572   1.000 10.203 0 63  LEU   D C     1 ? 
ATOM   2150 O  O     . LEU   B 2 63  ? 13.623  -25.574 1.472   1.000 12.056 0 63  LEU   D O     1 ? 
ATOM   2151 C  CB    . LEU   B 2 63  ? 14.796  -22.464 1.815   1.000 10.211 0 63  LEU   D CB    1 ? 
ATOM   2152 C  CG    . LEU   B 2 63  ? 15.001  -21.123 1.115   1.000 10.144 0 63  LEU   D CG    1 ? 
ATOM   2153 C  CD1   . LEU   B 2 63  ? 14.754  -19.958 2.076   1.000 11.809 0 63  LEU   D CD1   1 ? 
ATOM   2154 C  CD2   . LEU   B 2 63  ? 16.390  -20.986 0.475   1.000 10.779 0 63  LEU   D CD2   1 ? 
ATOM   2155 N  N     . ILE   B 2 64  ? 15.722  -25.530 2.317   1.000 10.310 0 64  ILE   D N     1 ? 
ATOM   2156 C  CA    . ILE   B 2 64  ? 15.696  -26.905 2.803   1.000 10.980 0 64  ILE   D CA    1 ? 
ATOM   2157 C  C     . ILE   B 2 64  ? 16.131  -26.954 4.259   1.000 11.553 0 64  ILE   D C     1 ? 
ATOM   2158 O  O     . ILE   B 2 64  ? 16.843  -26.088 4.778   1.000 10.844 0 64  ILE   D O     1 ? 
ATOM   2159 C  CB    . ILE   B 2 64  ? 16.575  -27.826 1.933   1.000 11.703 0 64  ILE   D CB    1 ? 
ATOM   2160 C  CG1   . ILE   B 2 64  ? 18.054  -27.480 2.073   1.000 12.104 0 64  ILE   D CG1   1 ? 
ATOM   2161 C  CG2   . ILE   B 2 64  ? 16.098  -27.805 0.496   1.000 13.083 0 64  ILE   D CG2   1 ? 
ATOM   2162 C  CD1   . ILE   B 2 64  ? 18.948  -28.424 1.271   1.000 13.988 0 64  ILE   D CD1   1 ? 
ATOM   2163 N  N     . GLN   B 2 65  ? 15.721  -28.032 4.945   1.000 12.304 0 65  GLN   D N     1 ? 
ATOM   2164 C  CA    . GLN   B 2 65  ? 16.028  -28.249 6.346   1.000 13.237 0 65  GLN   D CA    1 ? 
ATOM   2165 C  C     . GLN   B 2 65  ? 15.620  -27.034 7.186   1.000 13.006 0 65  GLN   D C     1 ? 
ATOM   2166 O  O     . GLN   B 2 65  ? 16.284  -26.687 8.156   1.000 15.618 0 65  GLN   D O     1 ? 
ATOM   2167 C  CB    . GLN   B 2 65  ? 17.515  -28.562 6.552   1.000 15.045 0 65  GLN   D CB    1 ? 
ATOM   2168 C  CG    . GLN   B 2 65  ? 17.891  -29.898 5.918   1.000 17.815 0 65  GLN   D CG    1 ? 
ATOM   2169 C  CD    . GLN   B 2 65  ? 19.160  -29.922 5.087   1.000 23.676 0 65  GLN   D CD    1 ? 
ATOM   2170 O  OE1   . GLN   B 2 65  ? 20.214  -29.390 5.449   1.000 23.808 0 65  GLN   D OE1   1 ? 
ATOM   2171 N  NE2   . GLN   B 2 65  ? 19.079  -30.584 3.948   1.000 27.575 0 65  GLN   D NE2   1 ? 
ATOM   2172 N  N     . VAL   B 2 66  ? 14.513  -26.385 6.815   1.000 11.627 0 66  VAL   D N     1 ? 
ATOM   2173 C  CA    . VAL   B 2 66  ? 14.104  -25.160 7.488   1.000 11.271 0 66  VAL   D CA    1 ? 
ATOM   2174 C  C     . VAL   B 2 66  ? 13.578  -25.496 8.877   1.000 13.080 0 66  VAL   D C     1 ? 
ATOM   2175 O  O     . VAL   B 2 66  ? 12.731  -26.380 9.023   1.000 12.725 0 66  VAL   D O     1 ? 
ATOM   2176 C  CB    . VAL   B 2 66  ? 13.057  -24.430 6.636   1.000 11.612 0 66  VAL   D CB    1 ? 
ATOM   2177 C  CG1   . VAL   B 2 66  ? 12.560  -23.166 7.326   1.000 12.361 0 66  VAL   D CG1   1 ? 
ATOM   2178 C  CG2   . VAL   B 2 66  ? 13.636  -24.125 5.257   1.000 11.569 0 66  VAL   D CG2   1 ? 
ATOM   2179 N  N     . PRO   B 2 67  ? 14.079  -24.849 9.948   1.000 11.497 0 67  PRO   D N     1 ? 
ATOM   2180 C  CA    . PRO   B 2 67  ? 13.562  -25.117 11.279  1.000 12.474 0 67  PRO   D CA    1 ? 
ATOM   2181 C  C     . PRO   B 2 67  ? 12.042  -24.985 11.317  1.000 14.674 0 67  PRO   D C     1 ? 
ATOM   2182 O  O     . PRO   B 2 67  ? 11.482  -24.037 10.795  1.000 12.166 0 67  PRO   D O     1 ? 
ATOM   2183 C  CB    . PRO   B 2 67  ? 14.242  -24.022 12.106  1.000 12.397 0 67  PRO   D CB    1 ? 
ATOM   2184 C  CG    . PRO   B 2 67  ? 15.538  -23.770 11.434  1.000 11.812 0 67  PRO   D CG    1 ? 
ATOM   2185 C  CD    . PRO   B 2 67  ? 15.142  -23.822 9.982   1.000 10.900 0 67  PRO   D CD    1 ? 
ATOM   2186 N  N     . LYS   B 2 68  ? 11.353  -25.958 11.947  1.000 16.943 0 68  LYS   D N     1 ? 
ATOM   2187 C  CA    . LYS   B 2 68  ? 9.903   -26.016 11.874  1.000 19.826 0 68  LYS   D CA    1 ? 
ATOM   2188 C  C     . LYS   B 2 68  ? 9.232   -25.145 12.935  1.000 16.943 0 68  LYS   D C     1 ? 
ATOM   2189 O  O     . LYS   B 2 68  ? 8.009   -25.007 12.905  1.000 19.983 0 68  LYS   D O     1 ? 
ATOM   2190 C  CB    . LYS   B 2 68  ? 9.411   -27.462 11.959  1.000 26.346 0 68  LYS   D CB    1 ? 
ATOM   2191 C  CG    . LYS   B 2 68  ? 9.537   -28.211 10.647  1.000 31.633 0 68  LYS   D CG    1 ? 
ATOM   2192 C  CD    . LYS   B 2 68  ? 9.124   -29.643 10.757  1.000 36.484 0 68  LYS   D CD    1 ? 
ATOM   2193 C  CE    . LYS   B 2 68  ? 9.519   -30.439 9.537   1.000 42.413 0 68  LYS   D CE    1 ? 
ATOM   2194 N  NZ    . LYS   B 2 68  ? 8.861   -31.764 9.552   1.000 49.676 0 68  LYS   D NZ    1 ? 
ATOM   2195 N  N     . GLY   B 2 69  ? 10.025  -24.503 13.793  1.000 15.131 0 69  GLY   D N     1 ? 
ATOM   2196 C  CA    . GLY   B 2 69  ? 9.560   -23.586 14.827  1.000 16.104 0 69  GLY   D CA    1 ? 
ATOM   2197 C  C     . GLY   B 2 69  ? 10.706  -23.178 15.749  1.000 20.185 0 69  GLY   D C     1 ? 
ATOM   2198 O  O     . GLY   B 2 69  ? 11.806  -23.668 15.585  1.000 19.229 0 69  GLY   D O     1 ? 
ATOM   2199 N  N     . PRO   B 2 70  ? 10.511  -22.322 16.779  1.000 25.228 0 70  PRO   D N     1 ? 
ATOM   2200 C  CA    . PRO   B 2 70  ? 11.562  -22.026 17.760  1.000 29.514 0 70  PRO   D CA    1 ? 
ATOM   2201 C  C     . PRO   B 2 70  ? 12.110  -23.198 18.564  1.000 34.352 0 70  PRO   D C     1 ? 
ATOM   2202 O  O     . PRO   B 2 70  ? 11.332  -23.934 19.151  1.000 40.267 0 70  PRO   D O     1 ? 
ATOM   2203 C  CB    . PRO   B 2 70  ? 10.836  -21.111 18.755  1.000 32.177 0 70  PRO   D CB    1 ? 
ATOM   2204 C  CG    . PRO   B 2 70  ? 9.755   -20.479 17.928  1.000 28.613 0 70  PRO   D CG    1 ? 
ATOM   2205 C  CD    . PRO   B 2 70  ? 9.259   -21.605 17.047  1.000 30.172 0 70  PRO   D CD    1 ? 
ATOM   2206 N  N     . VAL   B 2 71  ? 13.440  -23.364 18.605  1.000 38.275 0 71  VAL   D N     1 ? 
ATOM   2207 C  CA    . VAL   B 2 71  ? 14.031  -24.518 19.268  1.000 35.919 0 71  VAL   D CA    1 ? 
ATOM   2208 C  C     . VAL   B 2 71  ? 14.186  -24.239 20.759  1.000 35.555 0 71  VAL   D C     1 ? 
ATOM   2209 O  O     . VAL   B 2 71  ? 14.089  -23.091 21.222  1.000 38.431 0 71  VAL   D O     1 ? 
ATOM   2210 C  CB    . VAL   B 2 71  ? 15.381  -24.963 18.670  1.000 36.027 0 71  VAL   D CB    1 ? 
ATOM   2211 C  CG1   . VAL   B 2 71  ? 15.219  -25.508 17.261  1.000 38.089 0 71  VAL   D CG1   1 ? 
ATOM   2212 C  CG2   . VAL   B 2 71  ? 16.438  -23.867 18.731  1.000 35.680 0 71  VAL   D CG2   1 ? 
ATOM   2213 N  N     . GLU   B 2 72  ? 14.401  -25.344 21.484  1.000 43.254 0 72  GLU   D N     1 ? 
ATOM   2214 C  CA    . GLU   B 2 72  ? 14.754  -25.332 22.895  1.000 43.801 0 72  GLU   D CA    1 ? 
ATOM   2215 C  C     . GLU   B 2 72  ? 16.006  -24.475 23.095  1.000 38.697 0 72  GLU   D C     1 ? 
ATOM   2216 O  O     . GLU   B 2 72  ? 17.038  -24.669 22.418  1.000 36.118 0 72  GLU   D O     1 ? 
ATOM   2217 C  CB    . GLU   B 2 72  ? 14.977  -26.766 23.403  1.000 50.394 0 72  GLU   D CB    1 ? 
ATOM   2218 C  CG    . GLU   B 2 72  ? 13.716  -27.627 23.501  1.000 56.687 0 72  GLU   D CG    1 ? 
ATOM   2219 C  CD    . GLU   B 2 72  ? 13.188  -28.271 22.223  1.000 66.756 0 72  GLU   D CD    1 ? 
ATOM   2220 O  OE1   . GLU   B 2 72  ? 13.714  -27.966 21.116  1.000 67.894 0 72  GLU   D OE1   1 ? 
ATOM   2221 O  OE2   . GLU   B 2 72  ? 12.240  -29.093 22.330  1.000 70.687 0 72  GLU   D OE2   1 ? 
ATOM   2222 N  N     . GLY   B 2 73  ? 15.878  -23.501 24.006  1.000 36.392 0 73  GLY   D N     1 ? 
ATOM   2223 C  CA    . GLY   B 2 73  ? 16.969  -22.613 24.409  1.000 31.652 0 73  GLY   D CA    1 ? 
ATOM   2224 C  C     . GLY   B 2 73  ? 17.466  -21.656 23.315  1.000 27.687 0 73  GLY   D C     1 ? 
ATOM   2225 O  O     . GLY   B 2 73  ? 18.628  -21.285 23.327  1.000 26.588 0 73  GLY   D O     1 ? 
ATOM   2226 N  N     . TYR   B 2 74  ? 16.601  -21.184 22.413  1.000 26.502 0 74  TYR   D N     1 ? 
ATOM   2227 C  CA    . TYR   B 2 74  ? 17.124  -20.668 21.147  1.000 22.666 0 74  TYR   D CA    1 ? 
ATOM   2228 C  C     . TYR   B 2 74  ? 17.988  -19.419 21.333  1.000 22.724 0 74  TYR   D C     1 ? 
ATOM   2229 O  O     . TYR   B 2 74  ? 18.833  -19.184 20.489  1.000 20.656 0 74  TYR   D O     1 ? 
ATOM   2230 C  CB    . TYR   B 2 74  ? 16.025  -20.379 20.116  1.000 23.421 0 74  TYR   D CB    1 ? 
ATOM   2231 C  CG    . TYR   B 2 74  ? 15.063  -19.301 20.503  1.000 21.679 0 74  TYR   D CG    1 ? 
ATOM   2232 C  CD1   . TYR   B 2 74  ? 15.363  -17.962 20.350  1.000 25.037 0 74  TYR   D CD1   1 ? 
ATOM   2233 C  CD2   . TYR   B 2 74  ? 13.877  -19.622 21.148  1.000 25.345 0 74  TYR   D CD2   1 ? 
ATOM   2234 C  CE1   . TYR   B 2 74  ? 14.489  -16.966 20.738  1.000 21.762 0 74  TYR   D CE1   1 ? 
ATOM   2235 C  CE2   . TYR   B 2 74  ? 13.005  -18.639 21.574  1.000 26.066 0 74  TYR   D CE2   1 ? 
ATOM   2236 C  CZ    . TYR   B 2 74  ? 13.302  -17.307 21.372  1.000 27.406 0 74  TYR   D CZ    1 ? 
ATOM   2237 O  OH    . TYR   B 2 74  ? 12.431  -16.329 21.776  1.000 29.885 0 74  TYR   D OH    1 ? 
ATOM   2238 N  N     . GLU   B 2 75  ? 17.826  -18.608 22.387  1.000 21.955 0 75  GLU   D N     1 ? 
ATOM   2239 C  CA    . GLU   B 2 75  ? 18.714  -17.458 22.542  1.000 23.115 0 75  GLU   D CA    1 ? 
ATOM   2240 C  C     . GLU   B 2 75  ? 20.166  -17.875 22.763  1.000 23.056 0 75  GLU   D C     1 ? 
ATOM   2241 O  O     . GLU   B 2 75  ? 21.039  -17.065 22.512  1.000 22.560 0 75  GLU   D O     1 ? 
ATOM   2242 C  CB    . GLU   B 2 75  ? 18.364  -16.576 23.738  1.000 27.514 0 75  GLU   D CB    1 ? 
ATOM   2243 C  CG    . GLU   B 2 75  ? 16.993  -15.940 23.638  1.000 30.436 0 75  GLU   D CG    1 ? 
ATOM   2244 C  CD    . GLU   B 2 75  ? 15.872  -16.757 24.263  1.000 35.348 0 75  GLU   D CD    1 ? 
ATOM   2245 O  OE1   . GLU   B 2 75  ? 16.010  -18.024 24.405  1.000 31.539 0 75  GLU   D OE1   1 ? 
ATOM   2246 O  OE2   . GLU   B 2 75  ? 14.881  -16.118 24.652  1.000 38.167 0 75  GLU   D OE2   1 ? 
ATOM   2247 N  N     . GLU   B 2 76  ? 20.391  -19.091 23.255  1.000 23.240 0 76  GLU   D N     1 ? 
ATOM   2248 C  CA    . GLU   B 2 76  ? 21.729  -19.614 23.497  1.000 24.775 0 76  GLU   D CA    1 ? 
ATOM   2249 C  C     . GLU   B 2 76  ? 22.180  -20.553 22.376  1.000 22.978 0 76  GLU   D C     1 ? 
ATOM   2250 O  O     . GLU   B 2 76  ? 23.302  -21.071 22.435  1.000 25.623 0 76  GLU   D O     1 ? 
ATOM   2251 C  CB    . GLU   B 2 76  ? 21.794  -20.384 24.828  1.000 26.988 0 76  GLU   D CB    1 ? 
ATOM   2252 C  CG    . GLU   B 2 76  ? 21.413  -19.581 26.068  1.000 29.785 0 76  GLU   D CG    1 ? 
ATOM   2253 C  CD    . GLU   B 2 76  ? 22.074  -18.221 26.187  1.000 31.244 0 76  GLU   D CD    1 ? 
ATOM   2254 O  OE1   . GLU   B 2 76  ? 23.285  -18.102 25.847  1.000 32.940 0 76  GLU   D OE1   1 ? 
ATOM   2255 O  OE2   . GLU   B 2 76  ? 21.387  -17.285 26.665  1.000 36.981 0 76  GLU   D OE2   1 ? 
ATOM   2256 N  N     . ASN   B 2 77  ? 21.340  -20.745 21.339  1.000 19.466 0 77  ASN   D N     1 ? 
ATOM   2257 C  CA    . ASN   B 2 77  ? 21.642  -21.696 20.280  1.000 19.358 0 77  ASN   D CA    1 ? 
ATOM   2258 C  C     . ASN   B 2 77  ? 22.206  -20.903 19.096  1.000 19.619 0 77  ASN   D C     1 ? 
ATOM   2259 O  O     . ASN   B 2 77  ? 21.427  -20.463 18.259  1.000 17.336 0 77  ASN   D O     1 ? 
ATOM   2260 C  CB    . ASN   B 2 77  ? 20.416  -22.555 19.959  1.000 21.412 0 77  ASN   D CB    1 ? 
ATOM   2261 C  CG    . ASN   B 2 77  ? 20.691  -23.653 18.958  1.000 20.315 0 77  ASN   D CG    1 ? 
ATOM   2262 O  OD1   . ASN   B 2 77  ? 21.625  -23.593 18.160  1.000 23.784 0 77  ASN   D OD1   1 ? 
ATOM   2263 N  ND2   . ASN   B 2 77  ? 19.877  -24.692 18.992  1.000 25.937 0 77  ASN   D ND2   1 ? 
ATOM   2264 N  N     . GLU   B 2 78  ? 23.539  -20.715 19.011  1.000 20.035 0 78  GLU   D N     1 ? 
ATOM   2265 C  CA    . GLU   B 2 78  ? 24.123  -19.859 17.996  1.000 21.045 0 78  GLU   D CA    1 ? 
ATOM   2266 C  C     . GLU   B 2 78  ? 23.849  -20.447 16.614  1.000 19.533 0 78  GLU   D C     1 ? 
ATOM   2267 O  O     . GLU   B 2 78  ? 23.606  -19.690 15.688  1.000 18.372 0 78  GLU   D O     1 ? 
ATOM   2268 C  CB    . GLU   B 2 78  ? 25.632  -19.615 18.189  1.000 26.529 0 78  GLU   D CB    1 ? 
ATOM   2269 C  CG    . GLU   B 2 78  ? 26.203  -18.608 17.184  1.000 34.576 0 78  GLU   D CG    1 ? 
ATOM   2270 C  CD    . GLU   B 2 78  ? 27.666  -18.203 17.324  1.000 45.345 0 78  GLU   D CD    1 ? 
ATOM   2271 O  OE1   . GLU   B 2 78  ? 28.391  -18.831 18.132  1.000 51.026 0 78  GLU   D OE1   1 ? 
ATOM   2272 O  OE2   . GLU   B 2 78  ? 28.080  -17.248 16.617  1.000 46.320 0 78  GLU   D OE2   1 ? 
ATOM   2273 N  N     . GLU   B 2 79  ? 23.874  -21.769 16.479  1.000 19.920 0 79  GLU   D N     1 ? 
ATOM   2274 C  CA    . GLU   B 2 79  ? 23.602  -22.392 15.191  1.000 22.495 0 79  GLU   D CA    1 ? 
ATOM   2275 C  C     . GLU   B 2 79  ? 22.195  -22.047 14.690  1.000 16.571 0 79  GLU   D C     1 ? 
ATOM   2276 O  O     . GLU   B 2 79  ? 22.038  -21.710 13.505  1.000 15.184 0 79  GLU   D O     1 ? 
ATOM   2277 C  CB    . GLU   B 2 79  ? 23.837  -23.902 15.284  1.000 26.644 0 79  GLU   D CB    1 ? 
ATOM   2278 C  CG    . GLU   B 2 79  ? 25.290  -24.257 15.626  1.000 35.041 0 79  GLU   D CG    1 ? 
ATOM   2279 C  CD    . GLU   B 2 79  ? 25.732  -24.286 17.095  1.000 39.263 0 79  GLU   D CD    1 ? 
ATOM   2280 O  OE1   . GLU   B 2 79  ? 24.880  -24.120 18.036  1.000 37.289 0 79  GLU   D OE1   1 ? 
ATOM   2281 O  OE2   . GLU   B 2 79  ? 26.961  -24.487 17.312  1.000 44.517 0 79  GLU   D OE2   1 ? 
ATOM   2282 N  N     . PHE   B 2 80  ? 21.173  -22.200 15.534  1.000 14.981 0 80  PHE   D N     1 ? 
ATOM   2283 C  CA    . PHE   B 2 80  ? 19.799  -21.858 15.156  1.000 13.153 0 80  PHE   D CA    1 ? 
ATOM   2284 C  C     . PHE   B 2 80  ? 19.712  -20.370 14.819  1.000 13.126 0 80  PHE   D C     1 ? 
ATOM   2285 O  O     . PHE   B 2 80  ? 19.130  -20.032 13.797  1.000 10.773 0 80  PHE   D O     1 ? 
ATOM   2286 C  CB    . PHE   B 2 80  ? 18.848  -22.217 16.295  1.000 13.640 0 80  PHE   D CB    1 ? 
ATOM   2287 C  CG    . PHE   B 2 80  ? 17.425  -21.767 16.123  1.000 12.533 0 80  PHE   D CG    1 ? 
ATOM   2288 C  CD1   . PHE   B 2 80  ? 16.501  -22.454 15.338  1.000 14.140 0 80  PHE   D CD1   1 ? 
ATOM   2289 C  CD2   . PHE   B 2 80  ? 17.020  -20.582 16.679  1.000 13.038 0 80  PHE   D CD2   1 ? 
ATOM   2290 C  CE1   . PHE   B 2 80  ? 15.189  -22.007 15.247  1.000 14.196 0 80  PHE   D CE1   1 ? 
ATOM   2291 C  CE2   . PHE   B 2 80  ? 15.716  -20.144 16.579  1.000 13.253 0 80  PHE   D CE2   1 ? 
ATOM   2292 C  CZ    . PHE   B 2 80  ? 14.822  -20.822 15.820  1.000 13.304 0 80  PHE   D CZ    1 ? 
ATOM   2293 N  N     . LEU   B 2 81  ? 20.321  -19.487 15.591  1.000 11.132 0 81  LEU   D N     1 ? 
ATOM   2294 C  CA    . LEU   B 2 81  ? 20.251  -18.062 15.271  1.000 11.202 0 81  LEU   D CA    1 ? 
ATOM   2295 C  C     . LEU   B 2 81  ? 20.956  -17.775 13.945  1.000 11.468 0 81  LEU   D C     1 ? 
ATOM   2296 O  O     . LEU   B 2 81  ? 20.443  -16.985 13.158  1.000 10.078 0 81  LEU   D O     1 ? 
ATOM   2297 C  CB    . LEU   B 2 81  ? 20.834  -17.203 16.404  1.000 11.965 0 81  LEU   D CB    1 ? 
ATOM   2298 C  CG    . LEU   B 2 81  ? 20.094  -17.306 17.743  1.000 12.592 0 81  LEU   D CG    1 ? 
ATOM   2299 C  CD1   . LEU   B 2 81  ? 20.834  -16.492 18.794  1.000 14.624 0 81  LEU   D CD1   1 ? 
ATOM   2300 C  CD2   . LEU   B 2 81  ? 18.647  -16.834 17.626  1.000 12.744 0 81  LEU   D CD2   1 ? 
ATOM   2301 N  N     . ARG   B 2 82  ? 22.125  -18.390 13.693  1.000 11.119 0 82  ARG   D N     1 ? 
ATOM   2302 C  CA    . ARG   B 2 82  ? 22.817  -18.202 12.430  1.000 12.523 0 82  ARG   D CA    1 ? 
ATOM   2303 C  C     . ARG   B 2 82  ? 21.978  -18.704 11.247  1.000 11.635 0 82  ARG   D C     1 ? 
ATOM   2304 O  O     . ARG   B 2 82  ? 21.925  -18.044 10.194  1.000 10.439 0 82  ARG   D O     1 ? 
ATOM   2305 C  CB    . ARG   B 2 82  ? 24.199  -18.872 12.462  1.000 14.971 0 82  ARG   D CB    1 ? 
ATOM   2306 C  CG    . ARG   B 2 82  ? 25.057  -18.415 11.301  1.000 21.065 0 82  ARG   D CG    1 ? 
ATOM   2307 C  CD    . ARG   B 2 82  ? 26.568  -18.418 11.478  1.000 26.038 0 82  ARG   D CD    1 ? 
ATOM   2308 N  NE    . ARG   B 2 82  ? 27.076  -17.698 12.632  1.000 29.385 0 82  ARG   D NE    1 ? 
ATOM   2309 C  CZ    . ARG   B 2 82  ? 27.785  -16.558 12.608  1.000 29.901 0 82  ARG   D CZ    1 ? 
ATOM   2310 N  NH1   . ARG   B 2 82  ? 27.743  -15.705 11.589  1.000 24.028 0 82  ARG   D NH1   1 ? 
ATOM   2311 N  NH2   . ARG   B 2 82  ? 28.489  -16.237 13.678  1.000 32.493 0 82  ARG   D NH2   1 ? 
ATOM   2312 N  N     . THR   B 2 83  ? 21.365  -19.888 11.387  1.000 9.468  0 83  THR   D N     1 ? 
ATOM   2313 C  CA    . THR   B 2 83  ? 20.493  -20.441 10.362  1.000 9.285  0 83  THR   D CA    1 ? 
ATOM   2314 C  C     . THR   B 2 83  ? 19.321  -19.491 10.067  1.000 8.813  0 83  THR   D C     1 ? 
ATOM   2315 O  O     . THR   B 2 83  ? 19.013  -19.192 8.916   1.000 8.815  0 83  THR   D O     1 ? 
ATOM   2316 C  CB    . THR   B 2 83  ? 19.992  -21.836 10.751  1.000 10.663 0 83  THR   D CB    1 ? 
ATOM   2317 O  OG1   . THR   B 2 83  ? 21.141  -22.683 10.814  1.000 13.550 0 83  THR   D OG1   1 ? 
ATOM   2318 C  CG2   . THR   B 2 83  ? 18.975  -22.434 9.827   1.000 11.427 0 83  THR   D CG2   1 ? 
ATOM   2319 N  N     . MET   B 2 84  ? 18.636  -19.049 11.107  1.000 8.297  0 84  MET   D N     1 ? 
ATOM   2320 C  CA    . MET   B 2 84  ? 17.507  -18.157 10.931  1.000 8.676  0 84  MET   D CA    1 ? 
ATOM   2321 C  C     . MET   B 2 84  ? 17.944  -16.819 10.357  1.000 8.276  0 84  MET   D C     1 ? 
ATOM   2322 O  O     . MET   B 2 84  ? 17.195  -16.212 9.582   1.000 8.171  0 84  MET   D O     1 ? 
ATOM   2323 C  CB    . MET   B 2 84  ? 16.765  -18.020 12.260  1.000 8.577  0 84  MET   D CB    1 ? 
ATOM   2324 C  CG    . MET   B 2 84  ? 16.057  -19.321 12.688  1.000 10.007 0 84  MET   D CG    1 ? 
ATOM   2325 S  SD    . MET   B 2 84  ? 14.862  -19.951 11.536  1.000 11.444 0 84  MET   D SD    1 ? 
ATOM   2326 C  CE    . MET   B 2 84  ? 13.789  -18.528 11.305  1.000 12.151 0 84  MET   D CE    1 ? 
ATOM   2327 N  N     . HIS   B 2 85  ? 19.101  -16.297 10.764  1.000 8.226  0 85  HIS   D N     1 ? 
ATOM   2328 C  CA    . HIS   B 2 85  ? 19.654  -15.083 10.142  1.000 8.609  0 85  HIS   D CA    1 ? 
ATOM   2329 C  C     . HIS   B 2 85  ? 19.728  -15.264 8.638   1.000 8.231  0 85  HIS   D C     1 ? 
ATOM   2330 O  O     . HIS   B 2 85  ? 19.279  -14.414 7.854   1.000 7.988  0 85  HIS   D O     1 ? 
ATOM   2331 C  CB    . HIS   B 2 85  ? 21.060  -14.831 10.676  1.000 8.944  0 85  HIS   D CB    1 ? 
ATOM   2332 C  CG    . HIS   B 2 85  ? 21.799  -13.750 9.956   1.000 8.948  0 85  HIS   D CG    1 ? 
ATOM   2333 N  ND1   . HIS   B 2 85  ? 21.598  -12.399 10.174  1.000 10.257 0 85  HIS   D ND1   1 ? 
ATOM   2334 C  CD2   . HIS   B 2 85  ? 22.765  -13.838 8.988   1.000 10.124 0 85  HIS   D CD2   1 ? 
ATOM   2335 C  CE1   . HIS   B 2 85  ? 22.382  -11.718 9.328   1.000 10.300 0 85  HIS   D CE1   1 ? 
ATOM   2336 N  NE2   . HIS   B 2 85  ? 23.094  -12.556 8.607   1.000 10.104 0 85  HIS   D NE2   1 ? 
ATOM   2337 N  N     . HIS   B 2 86  ? 20.301  -16.404 8.214   1.000 7.444  0 86  HIS   D N     1 ? 
ATOM   2338 C  CA    . HIS   B 2 86  ? 20.455  -16.603 6.774   1.000 6.776  0 86  HIS   D CA    1 ? 
ATOM   2339 C  C     . HIS   B 2 86  ? 19.082  -16.638 6.079   1.000 7.495  0 86  HIS   D C     1 ? 
ATOM   2340 O  O     . HIS   B 2 86  ? 18.874  -16.049 5.011   1.000 7.987  0 86  HIS   D O     1 ? 
ATOM   2341 C  CB    . HIS   B 2 86  ? 21.265  -17.895 6.515   1.000 7.906  0 86  HIS   D CB    1 ? 
ATOM   2342 C  CG    . HIS   B 2 86  ? 21.399  -18.222 5.101   1.000 7.964  0 86  HIS   D CG    1 ? 
ATOM   2343 N  ND1   . HIS   B 2 86  ? 22.256  -17.548 4.279   1.000 8.189  0 86  HIS   D ND1   1 ? 
ATOM   2344 C  CD2   . HIS   B 2 86  ? 20.819  -19.182 4.354   1.000 8.281  0 86  HIS   D CD2   1 ? 
ATOM   2345 C  CE1   . HIS   B 2 86  ? 22.121  -18.012 3.038   1.000 7.908  0 86  HIS   D CE1   1 ? 
ATOM   2346 N  NE2   . HIS   B 2 86  ? 21.308  -19.074 3.048   1.000 8.261  0 86  HIS   D NE2   1 ? 
ATOM   2347 N  N     . LEU   B 2 87  ? 18.165  -17.448 6.626   1.000 7.221  0 87  LEU   D N     1 ? 
ATOM   2348 C  CA    . LEU   B 2 87  ? 16.910  -17.696 5.934   1.000 7.191  0 87  LEU   D CA    1 ? 
ATOM   2349 C  C     . LEU   B 2 87  ? 16.035  -16.422 5.936   1.000 7.922  0 87  LEU   D C     1 ? 
ATOM   2350 O  O     . LEU   B 2 87  ? 15.300  -16.188 4.964   1.000 8.125  0 87  LEU   D O     1 ? 
ATOM   2351 C  CB    . LEU   B 2 87  ? 16.183  -18.878 6.594   1.000 7.496  0 87  LEU   D CB    1 ? 
ATOM   2352 C  CG    . LEU   B 2 87  ? 16.921  -20.221 6.537   1.000 8.762  0 87  LEU   D CG    1 ? 
ATOM   2353 C  CD1   . LEU   B 2 87  ? 16.195  -21.257 7.373   1.000 10.059 0 87  LEU   D CD1   1 ? 
ATOM   2354 C  CD2   . LEU   B 2 87  ? 17.090  -20.677 5.111   1.000 9.473  0 87  LEU   D CD2   1 ? 
ATOM   2355 N  N     . LEU   B 2 88  ? 16.074  -15.655 7.031   1.000 7.102  0 88  LEU   D N     1 ? 
ATOM   2356 C  CA    . LEU   B 2 88  ? 15.248  -14.440 7.160   1.000 7.208  0 88  LEU   D CA    1 ? 
ATOM   2357 C  C     . LEU   B 2 88  ? 15.812  -13.210 6.471   1.000 7.245  0 88  LEU   D C     1 ? 
ATOM   2358 O  O     . LEU   B 2 88  ? 15.042  -12.297 6.139   1.000 7.106  0 88  LEU   D O     1 ? 
ATOM   2359 C  CB    . LEU   B 2 88  ? 15.025  -14.121 8.647   1.000 7.411  0 88  LEU   D CB    1 ? 
ATOM   2360 C  CG    . LEU   B 2 88  ? 14.063  -15.048 9.391   1.000 8.430  0 88  LEU   D CG    1 ? 
ATOM   2361 C  CD1   . LEU   B 2 88  ? 14.166  -14.806 10.879  1.000 9.061  0 88  LEU   D CD1   1 ? 
ATOM   2362 C  CD2   . LEU   B 2 88  ? 12.629  -14.954 8.867   1.000 9.108  0 88  LEU   D CD2   1 ? 
ATOM   2363 N  N     . LEU   B 2 89  ? 17.143  -13.104 6.330   1.000 7.554  0 89  LEU   D N     1 ? 
ATOM   2364 C  CA    . LEU   B 2 89  ? 17.753  -11.838 5.929   1.000 7.997  0 89  LEU   D CA    1 ? 
ATOM   2365 C  C     . LEU   B 2 89  ? 18.656  -11.950 4.693   1.000 7.752  0 89  LEU   D C     1 ? 
ATOM   2366 O  O     . LEU   B 2 89  ? 18.934  -10.922 4.084   1.000 8.354  0 89  LEU   D O     1 ? 
ATOM   2367 C  CB    . LEU   B 2 89  ? 18.546  -11.248 7.090   1.000 8.805  0 89  LEU   D CB    1 ? 
ATOM   2368 C  CG    . LEU   B 2 89  ? 17.735  -10.857 8.319   1.000 10.071 0 89  LEU   D CG    1 ? 
ATOM   2369 C  CD1   . LEU   B 2 89  ? 18.637  -10.416 9.468   1.000 11.222 0 89  LEU   D CD1   1 ? 
ATOM   2370 C  CD2   . LEU   B 2 89  ? 16.701  -9.779  7.972   1.000 11.240 0 89  LEU   D CD2   1 ? 
ATOM   2371 N  N     . GLU   B 2 90  ? 19.164  -13.153 4.355   1.000 8.029  0 90  GLU   D N     1 ? 
ATOM   2372 C  CA    . GLU   B 2 90  ? 20.168  -13.274 3.302   1.000 8.347  0 90  GLU   D CA    1 ? 
ATOM   2373 C  C     . GLU   B 2 90  ? 19.653  -13.905 2.027   1.000 9.105  0 90  GLU   D C     1 ? 
ATOM   2374 O  O     . GLU   B 2 90  ? 20.388  -13.983 1.052   1.000 10.434 0 90  GLU   D O     1 ? 
ATOM   2375 C  CB    . GLU   B 2 90  ? 21.350  -14.069 3.820   1.000 8.669  0 90  GLU   D CB    1 ? 
ATOM   2376 C  CG    . GLU   B 2 90  ? 22.017  -13.468 5.062   1.000 9.413  0 90  GLU   D CG    1 ? 
ATOM   2377 C  CD    . GLU   B 2 90  ? 23.346  -14.082 5.478   1.000 9.823  0 90  GLU   D CD    1 ? 
ATOM   2378 O  OE1   . GLU   B 2 90  ? 23.477  -15.302 5.421   1.000 11.061 0 90  GLU   D OE1   1 ? 
ATOM   2379 O  OE2   . GLU   B 2 90  ? 24.262  -13.325 5.883   1.000 10.797 0 90  GLU   D OE2   1 ? 
ATOM   2380 N  N     . VAL   B 2 91  ? 18.396  -14.366 2.008   1.000 8.282  0 91  VAL   D N     1 ? 
ATOM   2381 C  CA    . VAL   B 2 91  ? 17.808  -14.955 0.815   1.000 9.017  0 91  VAL   D CA    1 ? 
ATOM   2382 C  C     . VAL   B 2 91  ? 16.847  -13.913 0.255   1.000 9.364  0 91  VAL   D C     1 ? 
ATOM   2383 O  O     . VAL   B 2 91  ? 15.786  -13.683 0.830   1.000 10.248 0 91  VAL   D O     1 ? 
ATOM   2384 C  CB    . VAL   B 2 91  ? 17.155  -16.321 1.056   1.000 8.825  0 91  VAL   D CB    1 ? 
ATOM   2385 C  CG1   . VAL   B 2 91  ? 16.630  -16.818 -0.271  1.000 9.852  0 91  VAL   D CG1   1 ? 
ATOM   2386 C  CG2   . VAL   B 2 91  ? 18.083  -17.320 1.736   1.000 8.793  0 91  VAL   D CG2   1 ? 
ATOM   2387 N  N     . GLU   B 2 92  ? 17.224  -13.269 -0.836  1.000 8.951  0 92  GLU   D N     1 ? 
ATOM   2388 C  CA    . GLU   B 2 92  ? 16.474  -12.139 -1.377  1.000 9.776  0 92  GLU   D CA    1 ? 
ATOM   2389 C  C     . GLU   B 2 92  ? 15.736  -12.558 -2.640  1.000 9.297  0 92  GLU   D C     1 ? 
ATOM   2390 O  O     . GLU   B 2 92  ? 16.340  -12.986 -3.623  1.000 9.993  0 92  GLU   D O     1 ? 
ATOM   2391 C  CB    . GLU   B 2 92  ? 17.433  -10.980 -1.649  1.000 12.194 0 92  GLU   D CB    1 ? 
ATOM   2392 C  CG    . GLU   B 2 92  ? 18.126  -10.478 -0.391  1.000 13.208 0 92  GLU   D CG    1 ? 
ATOM   2393 C  CD    . GLU   B 2 92  ? 18.917  -9.192  -0.599  1.000 15.910 0 92  GLU   D CD    1 ? 
ATOM   2394 O  OE1   . GLU   B 2 92  ? 19.204  -8.870  -1.746  1.000 18.276 0 92  GLU   D OE1   1 ? 
ATOM   2395 O  OE2   . GLU   B 2 92  ? 19.220  -8.493  0.376   1.000 19.627 0 92  GLU   D OE2   1 ? 
ATOM   2396 N  N     . VAL   B 2 93  ? 14.426  -12.307 -2.666  1.000 8.279  0 93  VAL   D N     1 ? 
ATOM   2397 C  CA    . VAL   B 2 93  ? 13.648  -12.381 -3.877  1.000 8.786  0 93  VAL   D CA    1 ? 
ATOM   2398 C  C     . VAL   B 2 93  ? 13.885  -11.117 -4.679  1.000 8.533  0 93  VAL   D C     1 ? 
ATOM   2399 O  O     . VAL   B 2 93  ? 13.557  -10.015 -4.221  1.000 9.288  0 93  VAL   D O     1 ? 
ATOM   2400 C  CB    . VAL   B 2 93  ? 12.150  -12.599 -3.577  1.000 9.066  0 93  VAL   D CB    1 ? 
ATOM   2401 C  CG1   . VAL   B 2 93  ? 11.374  -12.659 -4.850  1.000 8.510  0 93  VAL   D CG1   1 ? 
ATOM   2402 C  CG2   . VAL   B 2 93  ? 11.919  -13.877 -2.776  1.000 10.153 0 93  VAL   D CG2   1 ? 
ATOM   2403 N  N     . ILE   B 2 94  ? 14.402  -11.314 -5.901  1.000 8.786  0 94  ILE   D N     1 ? 
ATOM   2404 C  CA    . ILE   B 2 94  ? 14.610  -10.227 -6.855  1.000 9.598  0 94  ILE   D CA    1 ? 
ATOM   2405 C  C     . ILE   B 2 94  ? 13.457  -10.054 -7.834  1.000 8.460  0 94  ILE   D C     1 ? 
ATOM   2406 O  O     . ILE   B 2 94  ? 13.000  -8.934  -8.047  1.000 8.940  0 94  ILE   D O     1 ? 
ATOM   2407 C  CB    . ILE   B 2 94  ? 15.970  -10.388 -7.601  1.000 9.339  0 94  ILE   D CB    1 ? 
ATOM   2408 C  CG1   . ILE   B 2 94  ? 17.069  -10.649 -6.575  1.000 10.498 0 94  ILE   D CG1   1 ? 
ATOM   2409 C  CG2   . ILE   B 2 94  ? 16.278  -9.187  -8.498  1.000 10.925 0 94  ILE   D CG2   1 ? 
ATOM   2410 C  CD1   . ILE   B 2 94  ? 17.258  -9.612  -5.583  1.000 11.681 0 94  ILE   D CD1   1 ? 
ATOM   2411 N  N     . GLU   B 2 95  ? 12.973  -11.163 -8.391  1.000 9.062  0 95  GLU   D N     1 ? 
ATOM   2412 C  CA    . GLU   B 2 95  ? 11.867  -11.152 -9.335  1.000 8.639  0 95  GLU   D CA    1 ? 
ATOM   2413 C  C     . GLU   B 2 95  ? 10.890  -12.196 -8.830  1.000 8.627  0 95  GLU   D C     1 ? 
ATOM   2414 O  O     . GLU   B 2 95  ? 11.253  -13.336 -8.578  1.000 8.754  0 95  GLU   D O     1 ? 
ATOM   2415 C  CB    . GLU   B 2 95  ? 12.292  -11.423 -10.788 1.000 9.999  0 95  GLU   D CB    1 ? 
ATOM   2416 C  CG    . GLU   B 2 95  ? 13.362  -10.481 -11.304 1.000 10.699 0 95  GLU   D CG    1 ? 
ATOM   2417 C  CD    . GLU   B 2 95  ? 12.973  -9.028  -11.429 1.000 12.190 0 95  GLU   D CD    1 ? 
ATOM   2418 O  OE1   . GLU   B 2 95  ? 11.781  -8.787  -11.796 1.000 14.714 0 95  GLU   D OE1   1 ? 
ATOM   2419 O  OE2   . GLU   B 2 95  ? 13.861  -8.127  -11.240 1.000 12.968 0 95  GLU   D OE2   1 ? 
ATOM   2420 N  N     . GLY   B 2 96  ? 9.642   -11.784 -8.706  1.000 9.172  0 96  GLY   D N     1 ? 
ATOM   2421 C  CA    . GLY   B 2 96  ? 8.617   -12.672 -8.190  1.000 10.054 0 96  GLY   D CA    1 ? 
ATOM   2422 C  C     . GLY   B 2 96  ? 7.257   -12.009 -8.110  1.000 9.418  0 96  GLY   D C     1 ? 
ATOM   2423 O  O     . GLY   B 2 96  ? 7.036   -10.941 -8.684  1.000 9.114  0 96  GLY   D O     1 ? 
ATOM   2424 N  N     . THR   B 2 97  ? 6.364   -12.634 -7.309  1.000 9.165  0 97  THR   D N     1 ? 
ATOM   2425 C  CA    . THR   B 2 97  ? 5.018   -12.116 -7.078  1.000 9.903  0 97  THR   D CA    1 ? 
ATOM   2426 C  C     . THR   B 2 97  ? 4.579   -12.425 -5.659  1.000 9.961  0 97  THR   D C     1 ? 
ATOM   2427 O  O     . THR   B 2 97  ? 5.038   -13.411 -5.063  1.000 9.372  0 97  THR   D O     1 ? 
ATOM   2428 C  CB    . THR   B 2 97  ? 3.989   -12.747 -8.039  1.000 10.515 0 97  THR   D CB    1 ? 
ATOM   2429 O  OG1   . THR   B 2 97  ? 4.015   -14.172 -7.902  1.000 11.654 0 97  THR   D OG1   1 ? 
ATOM   2430 C  CG2   . THR   B 2 97  ? 4.207   -12.372 -9.488  1.000 11.508 0 97  THR   D CG2   1 ? 
ATOM   2431 N  N     . LEU   B 2 98  ? 3.693   -11.560 -5.173  1.000 8.979  0 98  LEU   D N     1 ? 
ATOM   2432 C  CA    . LEU   B 2 98  ? 2.962   -11.735 -3.938  1.000 9.623  0 98  LEU   D CA    1 ? 
ATOM   2433 C  C     . LEU   B 2 98  ? 1.492   -11.779 -4.320  1.000 9.095  0 98  LEU   D C     1 ? 
ATOM   2434 O  O     . LEU   B 2 98  ? 0.977   -10.834 -4.928  1.000 10.558 0 98  LEU   D O     1 ? 
ATOM   2435 C  CB    . LEU   B 2 98  ? 3.258   -10.563 -3.009  1.000 9.321  0 98  LEU   D CB    1 ? 
ATOM   2436 C  CG    . LEU   B 2 98  ? 4.683   -10.473 -2.508  1.000 10.011 0 98  LEU   D CG    1 ? 
ATOM   2437 C  CD1   . LEU   B 2 98  ? 4.910   -9.126  -1.870  1.000 11.057 0 98  LEU   D CD1   1 ? 
ATOM   2438 C  CD2   . LEU   B 2 98  ? 5.046   -11.594 -1.573  1.000 10.242 0 98  LEU   D CD2   1 ? 
ATOM   2439 N  N     . GLN   B 2 99  ? 0.816   -12.836 -3.939  1.000 8.852  0 99  GLN   D N     1 ? 
ATOM   2440 C  CA    . GLN   B 2 99  ? -0.587  -12.990 -4.285  1.000 8.909  0 99  GLN   D CA    1 ? 
ATOM   2441 C  C     . GLN   B 2 99  ? -1.495  -12.716 -3.095  1.000 8.524  0 99  GLN   D C     1 ? 
ATOM   2442 O  O     . GLN   B 2 99  ? -1.354  -13.310 -2.031  1.000 8.960  0 99  GLN   D O     1 ? 
ATOM   2443 C  CB    . GLN   B 2 99  ? -0.903  -14.374 -4.834  1.000 9.696  0 99  GLN   D CB    1 ? 
ATOM   2444 C  CG    . GLN   B 2 99  ? -2.266  -14.430 -5.515  1.000 10.977 0 99  GLN   D CG    1 ? 
ATOM   2445 C  CD    . GLN   B 2 99  ? -2.545  -15.775 -6.140  1.000 11.877 0 99  GLN   D CD    1 ? 
ATOM   2446 O  OE1   . GLN   B 2 99  ? -1.915  -16.795 -5.835  1.000 14.544 0 99  GLN   D OE1   1 ? 
ATOM   2447 N  NE2   . GLN   B 2 99  ? -3.477  -15.770 -7.075  1.000 12.109 0 99  GLN   D NE2   1 ? 
ATOM   2448 N  N     . CYS   B 2 100 ? -2.428  -11.761 -3.307  1.000 8.708  0 100 CYS   D N     1 ? 
ATOM   2449 C  CA    . CYS   B 2 100 ? -3.358  -11.372 -2.279  1.000 9.082  0 100 CYS   D CA    1 ? 
ATOM   2450 C  C     . CYS   B 2 100 ? -4.382  -12.475 -2.010  1.000 8.872  0 100 CYS   D C     1 ? 
ATOM   2451 O  O     . CYS   B 2 100 ? -5.105  -12.832 -2.929  1.000 8.921  0 100 CYS   D O     1 ? 
ATOM   2452 C  CB    . CYS   B 2 100 ? -3.991  -10.053 -2.711  1.000 9.933  0 100 CYS   D CB    1 ? 
ATOM   2453 S  SG    . CYS   B 2 100 ? -5.275  -9.462  -1.586  1.000 12.141 0 100 CYS   D SG    1 ? 
ATOM   2454 N  N     . PRO   B 2 101 ? -4.546  -12.961 -0.786  1.000 8.006  0 101 PRO   D N     1 ? 
ATOM   2455 C  CA    . PRO   B 2 101 ? -5.494  -14.062 -0.548  1.000 8.861  0 101 PRO   D CA    1 ? 
ATOM   2456 C  C     . PRO   B 2 101 ? -6.954  -13.687 -0.747  1.000 9.243  0 101 PRO   D C     1 ? 
ATOM   2457 O  O     . PRO   B 2 101 ? -7.759  -14.534 -1.172  1.000 9.794  0 101 PRO   D O     1 ? 
ATOM   2458 C  CB    . PRO   B 2 101 ? -5.194  -14.473 0.897   1.000 9.518  0 101 PRO   D CB    1 ? 
ATOM   2459 C  CG    . PRO   B 2 101 ? -4.551  -13.247 1.525   1.000 9.724  0 101 PRO   D CG    1 ? 
ATOM   2460 C  CD    . PRO   B 2 101 ? -3.711  -12.682 0.413   1.000 8.696  0 101 PRO   D CD    1 ? 
ATOM   2461 N  N     . GLU   B 2 102 ? -7.329  -12.434 -0.511  1.000 8.172  0 102 GLU   D N     1 ? 
ATOM   2462 C  CA    . GLU   B 2 102 ? -8.738  -12.044 -0.610  1.000 9.024  0 102 GLU   D CA    1 ? 
ATOM   2463 C  C     . GLU   B 2 102 ? -9.163  -11.730 -2.051  1.000 10.032 0 102 GLU   D C     1 ? 
ATOM   2464 O  O     . GLU   B 2 102 ? -10.364 -11.723 -2.311  1.000 10.182 0 102 GLU   D O     1 ? 
ATOM   2465 C  CB    . GLU   B 2 102 ? -9.129  -10.824 0.213   1.000 11.365 0 102 GLU   D CB    1 ? 
ATOM   2466 C  CG    . GLU   B 2 102 ? -9.053  -11.006 1.713   1.000 13.810 0 102 GLU   D CG    1 ? 
ATOM   2467 C  CD    . GLU   B 2 102 ? -7.655  -11.141 2.292   1.000 14.556 0 102 GLU   D CD    1 ? 
ATOM   2468 O  OE1   . GLU   B 2 102 ? -6.703  -10.476 1.752   1.000 14.269 0 102 GLU   D OE1   1 ? 
ATOM   2469 O  OE2   . GLU   B 2 102 ? -7.542  -11.843 3.349   1.000 17.781 0 102 GLU   D OE2   1 ? 
ATOM   2470 N  N     . SER   B 2 103 ? -8.242  -11.420 -2.981  1.000 8.632  0 103 SER   D N     1 ? 
ATOM   2471 C  CA    . SER   B 2 103 ? -8.595  -11.097 -4.352  1.000 9.704  0 103 SER   D CA    1 ? 
ATOM   2472 C  C     . SER   B 2 103 ? -8.069  -12.084 -5.367  1.000 10.155 0 103 SER   D C     1 ? 
ATOM   2473 O  O     . SER   B 2 103 ? -8.583  -12.110 -6.470  1.000 10.466 0 103 SER   D O     1 ? 
ATOM   2474 C  CB    . SER   B 2 103 ? -8.131  -9.706  -4.675  1.000 9.849  0 103 SER   D CB    1 ? 
ATOM   2475 O  OG    . SER   B 2 103 ? -6.687  -9.662  -4.702  1.000 11.168 0 103 SER   D OG    1 ? 
ATOM   2476 N  N     . GLY   B 2 104 ? -6.924  -12.722 -5.070  1.000 9.208  0 104 GLY   D N     1 ? 
ATOM   2477 C  CA    . GLY   B 2 104 ? -6.149  -13.464 -6.045  1.000 9.742  0 104 GLY   D CA    1 ? 
ATOM   2478 C  C     . GLY   B 2 104 ? -5.245  -12.609 -6.927  1.000 9.886  0 104 GLY   D C     1 ? 
ATOM   2479 O  O     . GLY   B 2 104 ? -4.612  -13.139 -7.829  1.000 10.648 0 104 GLY   D O     1 ? 
ATOM   2480 N  N     . ARG   B 2 105 ? -5.227  -11.275 -6.730  1.000 8.707  0 105 ARG   D N     1 ? 
ATOM   2481 C  CA    . ARG   B 2 105 ? -4.383  -10.405 -7.536  1.000 9.490  0 105 ARG   D CA    1 ? 
ATOM   2482 C  C     . ARG   B 2 105 ? -2.894  -10.628 -7.217  1.000 8.142  0 105 ARG   D C     1 ? 
ATOM   2483 O  O     . ARG   B 2 105 ? -2.530  -10.820 -6.058  1.000 9.053  0 105 ARG   D O     1 ? 
ATOM   2484 C  CB    . ARG   B 2 105 ? -4.792  -8.959  -7.295  1.000 11.004 0 105 ARG   D CB    1 ? 
ATOM   2485 C  CG    . ARG   B 2 105 ? -3.993  -7.930  -8.093  1.000 14.296 0 105 ARG   D CG    1 ? 
ATOM   2486 C  CD    . ARG   B 2 105 ? -4.514  -6.507  -8.006  1.000 17.166 0 105 ARG   D CD    1 ? 
ATOM   2487 N  NE    . ARG   B 2 105 ? -3.616  -5.633  -8.775  1.000 17.630 0 105 ARG   D NE    1 ? 
ATOM   2488 C  CZ    . ARG   B 2 105 ? -3.987  -4.543  -9.440  1.000 19.908 0 105 ARG   D CZ    1 ? 
ATOM   2489 N  NH1   . ARG   B 2 105 ? -5.262  -4.175  -9.515  1.000 23.094 0 105 ARG   D NH1   1 ? 
ATOM   2490 N  NH2   . ARG   B 2 105 ? -3.044  -3.833  -10.042 1.000 19.382 0 105 ARG   D NH2   1 ? 
ATOM   2491 N  N     . MET   B 2 106 ? -2.064  -10.562 -8.285  1.000 9.084  0 106 MET   D N     1 ? 
ATOM   2492 C  CA    . MET   B 2 106 ? -0.612  -10.610 -8.196  1.000 10.347 0 106 MET   D CA    1 ? 
ATOM   2493 C  C     . MET   B 2 106 ? -0.031  -9.222  -8.069  1.000 10.060 0 106 MET   D C     1 ? 
ATOM   2494 O  O     . MET   B 2 106 ? -0.406  -8.333  -8.802  1.000 12.667 0 106 MET   D O     1 ? 
ATOM   2495 C  CB    . MET   B 2 106 ? -0.053  -11.249 -9.451  1.000 12.396 0 106 MET   D CB    1 ? 
ATOM   2496 C  CG    . MET   B 2 106 ? -0.523  -12.656 -9.595  1.000 14.193 0 106 MET   D CG    1 ? 
ATOM   2497 S  SD    . MET   B 2 106 ? 0.242   -13.688 -8.322  1.000 17.249 0 106 MET   D SD    1 ? 
ATOM   2498 C  CE    . MET   B 2 106 ? -0.140  -15.341 -8.883  1.000 17.844 0 106 MET   D CE    1 ? 
ATOM   2499 N  N     . PHE   B 2 107 ? 0.830   -9.066  -7.068  1.000 9.726  0 107 PHE   D N     1 ? 
ATOM   2500 C  CA    . PHE   B 2 107 ? 1.587   -7.848  -6.868  1.000 9.525  0 107 PHE   D CA    1 ? 
ATOM   2501 C  C     . PHE   B 2 107 ? 3.031   -8.174  -7.192  1.000 9.958  0 107 PHE   D C     1 ? 
ATOM   2502 O  O     . PHE   B 2 107 ? 3.614   -9.095  -6.592  1.000 10.908 0 107 PHE   D O     1 ? 
ATOM   2503 C  CB    . PHE   B 2 107 ? 1.418   -7.375  -5.449  1.000 9.280  0 107 PHE   D CB    1 ? 
ATOM   2504 C  CG    . PHE   B 2 107 ? 0.017   -6.929  -5.184  1.000 9.024  0 107 PHE   D CG    1 ? 
ATOM   2505 C  CD1   . PHE   B 2 107 ? -0.975  -7.824  -4.834  1.000 9.911  0 107 PHE   D CD1   1 ? 
ATOM   2506 C  CD2   . PHE   B 2 107 ? -0.338  -5.615  -5.412  1.000 9.933  0 107 PHE   D CD2   1 ? 
ATOM   2507 C  CE1   . PHE   B 2 107 ? -2.283  -7.405  -4.694  1.000 10.178 0 107 PHE   D CE1   1 ? 
ATOM   2508 C  CE2   . PHE   B 2 107 ? -1.647  -5.192  -5.228  1.000 10.379 0 107 PHE   D CE2   1 ? 
ATOM   2509 C  CZ    . PHE   B 2 107 ? -2.616  -6.105  -4.869  1.000 9.851  0 107 PHE   D CZ    1 ? 
ATOM   2510 N  N     . PRO   B 2 108 ? 3.659   -7.520  -8.191  1.000 9.891  0 108 PRO   D N     1 ? 
ATOM   2511 C  CA    . PRO   B 2 108 ? 4.986   -7.931  -8.650  1.000 9.875  0 108 PRO   D CA    1 ? 
ATOM   2512 C  C     . PRO   B 2 108 ? 6.098   -7.480  -7.715  1.000 9.679  0 108 PRO   D C     1 ? 
ATOM   2513 O  O     . PRO   B 2 108 ? 6.067   -6.352  -7.193  1.000 10.855 0 108 PRO   D O     1 ? 
ATOM   2514 C  CB    . PRO   B 2 108 ? 5.071   -7.228  -10.003 1.000 10.695 0 108 PRO   D CB    1 ? 
ATOM   2515 C  CG    . PRO   B 2 108 ? 4.242   -5.996  -9.891  1.000 10.961 0 108 PRO   D CG    1 ? 
ATOM   2516 C  CD    . PRO   B 2 108 ? 3.091   -6.452  -9.012  1.000 10.704 0 108 PRO   D CD    1 ? 
ATOM   2517 N  N     . ILE   B 2 109 ? 7.099   -8.357  -7.564  1.000 8.452  0 109 ILE   D N     1 ? 
ATOM   2518 C  CA    . ILE   B 2 109 ? 8.399   -7.981  -7.009  1.000 8.596  0 109 ILE   D CA    1 ? 
ATOM   2519 C  C     . ILE   B 2 109 ? 9.367   -7.837  -8.174  1.000 8.806  0 109 ILE   D C     1 ? 
ATOM   2520 O  O     . ILE   B 2 109 ? 9.510   -8.771  -8.958  1.000 9.887  0 109 ILE   D O     1 ? 
ATOM   2521 C  CB    . ILE   B 2 109 ? 8.916   -9.077  -6.062  1.000 8.465  0 109 ILE   D CB    1 ? 
ATOM   2522 C  CG1   . ILE   B 2 109 ? 7.932   -9.308  -4.920  1.000 8.906  0 109 ILE   D CG1   1 ? 
ATOM   2523 C  CG2   . ILE   B 2 109 ? 10.297  -8.684  -5.531  1.000 8.358  0 109 ILE   D CG2   1 ? 
ATOM   2524 C  CD1   . ILE   B 2 109 ? 8.220   -10.590 -4.121  1.000 8.803  0 109 ILE   D CD1   1 ? 
ATOM   2525 N  N     . SER   B 2 110 ? 10.010  -6.667  -8.307  1.000 8.136  0 110 SER   D N     1 ? 
ATOM   2526 C  CA    . SER   B 2 110 ? 10.970  -6.469  -9.381  1.000 11.025 0 110 SER   D CA    1 ? 
ATOM   2527 C  C     . SER   B 2 110 ? 12.162  -5.715  -8.817  1.000 11.287 0 110 SER   D C     1 ? 
ATOM   2528 O  O     . SER   B 2 110 ? 11.999  -4.760  -8.050  1.000 10.189 0 110 SER   D O     1 ? 
ATOM   2529 C  CB    . SER   B 2 110 ? 10.361  -5.789  -10.523 1.000 13.164 0 110 SER   D CB    1 ? 
ATOM   2530 O  OG    . SER   B 2 110 ? 11.311  -5.840  -11.603 1.000 19.196 0 110 SER   D OG    1 ? 
ATOM   2531 N  N     . ARG   B 2 111 ? 13.378  -6.120  -9.215  1.000 10.744 0 111 ARG   D N     1 ? 
ATOM   2532 C  CA    . ARG   B 2 111 ? 14.595  -5.551  -8.662  1.000 11.554 0 111 ARG   D CA    1 ? 
ATOM   2533 C  C     . ARG   B 2 111 ? 14.599  -5.597  -7.139  1.000 10.730 0 111 ARG   D C     1 ? 
ATOM   2534 O  O     . ARG   B 2 111 ? 15.128  -4.718  -6.460  1.000 12.771 0 111 ARG   D O     1 ? 
ATOM   2535 C  CB    . ARG   B 2 111 ? 14.821  -4.138  -9.187  1.000 13.411 0 111 ARG   D CB    1 ? 
ATOM   2536 C  CG    . ARG   B 2 111 ? 14.883  -4.067  -10.708 1.000 18.018 0 111 ARG   D CG    1 ? 
ATOM   2537 C  CD    . ARG   B 2 111 ? 15.202  -2.656  -11.124 1.000 25.975 0 111 ARG   D CD    1 ? 
ATOM   2538 N  NE    . ARG   B 2 111 ? 14.254  -1.709  -10.525 1.000 37.693 0 111 ARG   D NE    1 ? 
ATOM   2539 C  CZ    . ARG   B 2 111 ? 14.492  -0.873  -9.497  1.000 35.122 0 111 ARG   D CZ    1 ? 
ATOM   2540 N  NH1   . ARG   B 2 111 ? 15.651  -0.849  -8.845  1.000 36.900 0 111 ARG   D NH1   1 ? 
ATOM   2541 N  NH2   . ARG   B 2 111 ? 13.534  -0.057  -9.125  1.000 33.749 0 111 ARG   D NH2   1 ? 
ATOM   2542 N  N     . GLY   B 2 112 ? 13.979  -6.661  -6.601  1.000 9.080  0 112 GLY   D N     1 ? 
ATOM   2543 C  CA    . GLY   B 2 112 ? 13.906  -6.819  -5.155  1.000 9.345  0 112 GLY   D CA    1 ? 
ATOM   2544 C  C     . GLY   B 2 112 ? 12.797  -6.058  -4.442  1.000 7.968  0 112 GLY   D C     1 ? 
ATOM   2545 O  O     . GLY   B 2 112 ? 12.608  -6.247  -3.245  1.000 8.809  0 112 GLY   D O     1 ? 
ATOM   2546 N  N     . ILE   B 2 113 ? 11.991  -5.258  -5.150  1.000 7.583  0 113 ILE   D N     1 ? 
ATOM   2547 C  CA    . ILE   B 2 113 ? 11.024  -4.356  -4.547  1.000 7.822  0 113 ILE   D CA    1 ? 
ATOM   2548 C  C     . ILE   B 2 113 ? 9.629   -4.847  -4.860  1.000 7.255  0 113 ILE   D C     1 ? 
ATOM   2549 O  O     . ILE   B 2 113 ? 9.190   -4.797  -6.018  1.000 8.422  0 113 ILE   D O     1 ? 
ATOM   2550 C  CB    . ILE   B 2 113 ? 11.245  -2.922  -5.044  1.000 9.114  0 113 ILE   D CB    1 ? 
ATOM   2551 C  CG1   . ILE   B 2 113 ? 12.708  -2.500  -4.846  1.000 9.541  0 113 ILE   D CG1   1 ? 
ATOM   2552 C  CG2   . ILE   B 2 113 ? 10.230  -1.966  -4.426  1.000 8.579  0 113 ILE   D CG2   1 ? 
ATOM   2553 C  CD1   . ILE   B 2 113 ? 13.064  -1.187  -5.523  1.000 11.879 0 113 ILE   D CD1   1 ? 
ATOM   2554 N  N     . PRO   B 2 114 ? 8.829   -5.135  -3.834  1.000 7.474  0 114 PRO   D N     1 ? 
ATOM   2555 C  CA    . PRO   B 2 114 ? 7.404   -5.412  -4.056  1.000 8.949  0 114 PRO   D CA    1 ? 
ATOM   2556 C  C     . PRO   B 2 114 ? 6.658   -4.119  -4.385  1.000 9.376  0 114 PRO   D C     1 ? 
ATOM   2557 O  O     . PRO   B 2 114 ? 6.893   -3.090  -3.763  1.000 9.722  0 114 PRO   D O     1 ? 
ATOM   2558 C  CB    . PRO   B 2 114 ? 6.887   -5.911  -2.709  1.000 9.532  0 114 PRO   D CB    1 ? 
ATOM   2559 C  CG    . PRO   B 2 114 ? 8.154   -6.344  -1.975  1.000 9.489  0 114 PRO   D CG    1 ? 
ATOM   2560 C  CD    . PRO   B 2 114 ? 9.231   -5.389  -2.432  1.000 8.413  0 114 PRO   D CD    1 ? 
ATOM   2561 N  N     . ASN   B 2 115 ? 5.808   -4.147  -5.408  1.000 8.180  0 115 ASN   D N     1 ? 
ATOM   2562 C  CA    . ASN   B 2 115 ? 4.944   -3.021  -5.774  1.000 8.614  0 115 ASN   D CA    1 ? 
ATOM   2563 C  C     . ASN   B 2 115 ? 3.530   -3.413  -5.334  1.000 8.855  0 115 ASN   D C     1 ? 
ATOM   2564 O  O     . ASN   B 2 115 ? 2.860   -4.232  -5.981  1.000 8.949  0 115 ASN   D O     1 ? 
ATOM   2565 C  CB    . ASN   B 2 115 ? 4.983   -2.698  -7.259  1.000 9.472  0 115 ASN   D CB    1 ? 
ATOM   2566 C  CG    . ASN   B 2 115 ? 4.056   -1.549  -7.596  1.000 10.780 0 115 ASN   D CG    1 ? 
ATOM   2567 O  OD1   . ASN   B 2 115 ? 3.400   -1.003  -6.708  1.000 11.450 0 115 ASN   D OD1   1 ? 
ATOM   2568 N  ND2   . ASN   B 2 115 ? 3.965   -1.214  -8.863  1.000 11.716 0 115 ASN   D ND2   1 ? 
ATOM   2569 N  N     . MET   B 2 116 ? 3.099   -2.809  -4.235  1.000 8.972  0 116 MET   D N     1 ? 
ATOM   2570 C  CA    . MET   B 2 116 ? 1.810   -3.103  -3.612  1.000 9.263  0 116 MET   D CA    1 ? 
ATOM   2571 C  C     . MET   B 2 116 ? 0.695   -2.160  -4.085  1.000 10.670 0 116 MET   D C     1 ? 
ATOM   2572 O  O     . MET   B 2 116 ? -0.426  -2.264  -3.549  1.000 12.161 0 116 MET   D O     1 ? 
ATOM   2573 C  CB    . MET   B 2 116 ? 1.957   -3.065  -2.089  1.000 10.864 0 116 MET   D CB    1 ? 
ATOM   2574 C  CG    . MET   B 2 116 ? 3.078   -3.971  -1.559  1.000 10.393 0 116 MET   D CG    1 ? 
ATOM   2575 S  SD    . MET   B 2 116 ? 2.941   -5.709  -2.036  1.000 11.303 0 116 MET   D SD    1 ? 
ATOM   2576 C  CE    . MET   B 2 116 ? 1.290   -6.126  -1.486  1.000 14.421 0 116 MET   D CE    1 ? 
ATOM   2577 N  N     . LEU   B 2 117 ? 0.924   -1.320  -5.096  1.000 10.486 0 117 LEU   D N     1 ? 
ATOM   2578 C  CA    . LEU   B 2 117 ? -0.154  -0.432  -5.557  1.000 10.646 0 117 LEU   D CA    1 ? 
ATOM   2579 C  C     . LEU   B 2 117 ? -1.218  -1.199  -6.361  1.000 11.668 0 117 LEU   D C     1 ? 
ATOM   2580 O  O     . LEU   B 2 117 ? -0.952  -2.186  -7.042  1.000 12.926 0 117 LEU   D O     1 ? 
ATOM   2581 C  CB    . LEU   B 2 117 ? 0.452   0.680   -6.405  1.000 11.212 0 117 LEU   D CB    1 ? 
ATOM   2582 C  CG    . LEU   B 2 117 ? 1.394   1.621   -5.677  1.000 10.528 0 117 LEU   D CG    1 ? 
ATOM   2583 C  CD1   . LEU   B 2 117 ? 2.016   2.599   -6.687  1.000 11.419 0 117 LEU   D CD1   1 ? 
ATOM   2584 C  CD2   . LEU   B 2 117 ? 0.638   2.428   -4.621  1.000 12.518 0 117 LEU   D CD2   1 ? 
ATOM   2585 N  N     . LEU   B 2 118 ? -2.451  -0.669  -6.373  1.000 13.962 0 118 LEU   D N     1 ? 
ATOM   2586 C  CA    . LEU   B 2 118 ? -3.515  -1.173  -7.244  1.000 17.333 0 118 LEU   D CA    1 ? 
ATOM   2587 C  C     . LEU   B 2 118 ? -3.507  -0.367  -8.533  1.000 20.613 0 118 LEU   D C     1 ? 
ATOM   2588 O  O     . LEU   B 2 118 ? -4.462  0.339   -8.867  1.000 24.168 0 118 LEU   D O     1 ? 
ATOM   2589 C  CB    . LEU   B 2 118 ? -4.869  -1.063  -6.547  1.000 20.380 0 118 LEU   D CB    1 ? 
ATOM   2590 C  CG    . LEU   B 2 118 ? -5.208  -2.131  -5.520  1.000 22.609 0 118 LEU   D CG    1 ? 
ATOM   2591 C  CD1   . LEU   B 2 118 ? -6.649  -1.991  -5.088  1.000 19.995 0 118 LEU   D CD1   1 ? 
ATOM   2592 C  CD2   . LEU   B 2 118 ? -4.984  -3.526  -6.067  1.000 24.713 0 118 LEU   D CD2   1 ? 
ATOM   2593 N  N     . SER   B 2 119 ? -2.433  -0.538  -9.303  1.000 22.013 0 119 SER   D N     1 ? 
ATOM   2594 C  CA    . SER   B 2 119 ? -2.284  0.074   -10.613 1.000 26.656 0 119 SER   D CA    1 ? 
ATOM   2595 C  C     . SER   B 2 119 ? -3.513  -0.207  -11.503 1.000 26.221 0 119 SER   D C     1 ? 
ATOM   2596 O  O     . SER   B 2 119 ? -4.044  -1.343  -11.410 1.000 28.246 0 119 SER   D O     1 ? 
ATOM   2597 C  CB    . SER   B 2 119 ? -0.993  -0.410  -11.239 1.000 30.036 0 119 SER   D CB    1 ? 
ATOM   2598 O  OG    . SER   B 2 119 ? -0.907  -1.837  -11.175 1.000 28.563 0 119 SER   D OG    1 ? 
HETATM 2599 N  N     . SAM   C 3 .   ? 13.319  10.929  3.765   1.000 9.002  0 301 SAM   C N     1 ? 
HETATM 2600 C  CA    . SAM   C 3 .   ? 13.132  11.172  2.311   1.000 9.268  0 301 SAM   C CA    1 ? 
HETATM 2601 C  C     . SAM   C 3 .   ? 14.471  11.246  1.577   1.000 9.888  0 301 SAM   C C     1 ? 
HETATM 2602 O  O     . SAM   C 3 .   ? 14.431  11.233  0.299   1.000 10.745 0 301 SAM   C O     1 ? 
HETATM 2603 O  OXT   . SAM   C 3 .   ? 15.496  11.333  2.294   1.000 10.433 0 301 SAM   C OXT   1 ? 
HETATM 2604 C  CB    . SAM   C 3 .   ? 12.414  12.494  2.077   1.000 11.749 0 301 SAM   C CB    1 ? 
HETATM 2605 C  CG    . SAM   C 3 .   ? 10.943  12.421  2.024   1.000 14.142 0 301 SAM   C CG    1 ? 
HETATM 2606 S  SD    . SAM   C 3 .   ? 10.224  13.548  0.750   1.000 11.358 0 301 SAM   C SD    1 ? 
HETATM 2607 C  CE    . SAM   C 3 .   ? 10.302  15.059  1.718   1.000 15.078 0 301 SAM   C CE    1 ? 
HETATM 2608 C  "C5'" . SAM   C 3 .   ? 8.549   12.888  0.830   1.000 10.998 0 301 SAM   C "C5'" 1 ? 
HETATM 2609 C  "C4'" . SAM   C 3 .   ? 8.468   11.505  0.193   1.000 9.634  0 301 SAM   C "C4'" 1 ? 
HETATM 2610 O  "O4'" . SAM   C 3 .   ? 7.118   11.020  0.313   1.000 10.287 0 301 SAM   C "O4'" 1 ? 
HETATM 2611 C  "C3'" . SAM   C 3 .   ? 8.814   11.407  -1.285  1.000 9.434  0 301 SAM   C "C3'" 1 ? 
HETATM 2612 O  "O3'" . SAM   C 3 .   ? 9.911   10.541  -1.567  1.000 10.544 0 301 SAM   C "O3'" 1 ? 
HETATM 2613 C  "C2'" . SAM   C 3 .   ? 7.511   10.959  -1.955  1.000 9.596  0 301 SAM   C "C2'" 1 ? 
HETATM 2614 O  "O2'" . SAM   C 3 .   ? 7.591   10.165  -3.120  1.000 9.447  0 301 SAM   C "O2'" 1 ? 
HETATM 2615 C  "C1'" . SAM   C 3 .   ? 6.816   10.218  -0.822  1.000 9.230  0 301 SAM   C "C1'" 1 ? 
HETATM 2616 N  N9    . SAM   C 3 .   ? 5.362   10.091  -0.881  1.000 8.624  0 301 SAM   C N9    1 ? 
HETATM 2617 C  C8    . SAM   C 3 .   ? 4.452   11.095  -1.174  1.000 8.951  0 301 SAM   C C8    1 ? 
HETATM 2618 N  N7    . SAM   C 3 .   ? 3.212   10.716  -1.012  1.000 9.120  0 301 SAM   C N7    1 ? 
HETATM 2619 C  C5    . SAM   C 3 .   ? 3.295   9.382   -0.615  1.000 7.772  0 301 SAM   C C5    1 ? 
HETATM 2620 C  C6    . SAM   C 3 .   ? 2.345   8.397   -0.277  1.000 8.773  0 301 SAM   C C6    1 ? 
HETATM 2621 N  N6    . SAM   C 3 .   ? 1.025   8.587   -0.270  1.000 9.242  0 301 SAM   C N6    1 ? 
HETATM 2622 N  N1    . SAM   C 3 .   ? 2.772   7.178   0.108   1.000 8.350  0 301 SAM   C N1    1 ? 
HETATM 2623 C  C2    . SAM   C 3 .   ? 4.087   6.950   0.122   1.000 9.774  0 301 SAM   C C2    1 ? 
HETATM 2624 N  N3    . SAM   C 3 .   ? 5.065   7.785   -0.194  1.000 7.970  0 301 SAM   C N3    1 ? 
HETATM 2625 C  C4    . SAM   C 3 .   ? 4.614   9.000   -0.532  1.000 8.757  0 301 SAM   C C4    1 ? 
HETATM 2626 C  C1    . A1CBE D 4 .   ? -4.195  2.714   -6.400  1.000 18.942 0 201 A1CBE D C1    1 ? 
HETATM 2627 C  C2    . A1CBE D 4 .   ? -4.993  3.511   -7.416  1.000 22.774 0 201 A1CBE D C2    1 ? 
HETATM 2628 O  O2    . A1CBE D 4 .   ? -2.837  -0.348  -0.892  1.000 12.639 0 201 A1CBE D O2    1 ? 
HETATM 2629 C  C4    . A1CBE D 4 .   ? -3.036  1.815   -3.792  1.000 13.393 0 201 A1CBE D C4    1 ? 
HETATM 2630 C  C5    . A1CBE D 4 .   ? -2.543  1.147   -2.691  1.000 12.660 0 201 A1CBE D C5    1 ? 
HETATM 2631 C  C6    . A1CBE D 4 .   ? -5.205  0.889   -3.402  1.000 15.228 0 201 A1CBE D C6    1 ? 
HETATM 2632 C  C7    . A1CBE D 4 .   ? -4.710  0.174   -2.313  1.000 14.851 0 201 A1CBE D C7    1 ? 
HETATM 2633 C  C8    . A1CBE D 4 .   ? -3.365  0.280   -1.991  1.000 12.411 0 201 A1CBE D C8    1 ? 
HETATM 2634 C  C9    . A1CBE D 4 .   ? -3.403  -1.625  -0.438  1.000 11.278 0 201 A1CBE D C9    1 ? 
HETATM 2635 C  C12   . A1CBE D 4 .   ? -0.868  -3.809  1.366   1.000 9.873  0 201 A1CBE D C12   1 ? 
HETATM 2636 C  C13   . A1CBE D 4 .   ? 0.280   -3.012  1.323   1.000 9.393  0 201 A1CBE D C13   1 ? 
HETATM 2637 C  C14   . A1CBE D 4 .   ? 1.408   -3.358  2.034   1.000 10.588 0 201 A1CBE D C14   1 ? 
HETATM 2638 C  C15   . A1CBE D 4 .   ? 1.479   -4.555  2.703   1.000 10.277 0 201 A1CBE D C15   1 ? 
HETATM 2639 C  C16   . A1CBE D 4 .   ? 0.359   -5.367  2.740   1.000 9.847  0 201 A1CBE D C16   1 ? 
HETATM 2640 C  C17   . A1CBE D 4 .   ? -0.797  -5.022  2.058   1.000 10.232 0 201 A1CBE D C17   1 ? 
HETATM 2641 C  C19   . A1CBE D 4 .   ? -1.974  -3.583  -0.903  1.000 10.354 0 201 A1CBE D C19   1 ? 
HETATM 2642 C  C20   . A1CBE D 4 .   ? -2.187  -5.001  -1.403  1.000 11.012 0 201 A1CBE D C20   1 ? 
HETATM 2643 CL CL1   . A1CBE D 4 .   ? 2.837   -2.341  1.928   1.000 12.267 0 201 A1CBE D CL1   1 ? 
HETATM 2644 O  O1    . A1CBE D 4 .   ? -3.047  2.263   -6.658  1.000 17.555 0 201 A1CBE D O1    1 ? 
HETATM 2645 N  N1    . A1CBE D 4 .   ? -4.862  2.430   -5.257  1.000 16.887 0 201 A1CBE D N1    1 ? 
HETATM 2646 C  C3    . A1CBE D 4 .   ? -4.377  1.732   -4.122  1.000 14.255 0 201 A1CBE D C3    1 ? 
HETATM 2647 C  C10   . A1CBE D 4 .   ? -2.576  -1.974  0.789   1.000 9.616  0 201 A1CBE D C10   1 ? 
HETATM 2648 C  C11   . A1CBE D 4 .   ? -2.119  -3.436  0.607   1.000 9.406  0 201 A1CBE D C11   1 ? 
HETATM 2649 C  C18   . A1CBE D 4 .   ? -3.147  -2.761  -1.448  1.000 10.855 0 201 A1CBE D C18   1 ? 
HETATM 2650 N  N2    . A1CBE D 4 .   ? -3.650  -5.093  -1.405  1.000 12.461 0 201 A1CBE D N2    1 ? 
HETATM 2651 C  C21   . A1CBE D 4 .   ? -4.284  -6.245  -1.135  1.000 14.890 0 201 A1CBE D C21   1 ? 
HETATM 2652 C  C22   . A1CBE D 4 .   ? -3.537  -7.475  -0.704  1.000 16.350 0 201 A1CBE D C22   1 ? 
HETATM 2653 C  C23   . A1CBE D 4 .   ? -4.466  -8.584  -0.259  1.000 14.884 0 201 A1CBE D C23   1 ? 
HETATM 2654 O  O3    . A1CBE D 4 .   ? -5.495  -6.189  -1.153  1.000 17.460 0 201 A1CBE D O3    1 ? 
HETATM 2655 C  C24   . A1CBE D 4 .   ? -4.287  -3.777  -1.568  1.000 12.273 0 201 A1CBE D C24   1 ? 
HETATM 2656 C  C1    . GOL   E 5 .   ? 10.043  -6.929  21.756  1.000 32.801 0 202 GOL   D C1    1 ? 
HETATM 2657 O  O1    . GOL   E 5 .   ? 9.060   -5.897  21.881  1.000 37.862 0 202 GOL   D O1    1 ? 
HETATM 2658 C  C2    . GOL   E 5 .   ? 11.141  -6.834  22.789  1.000 30.627 0 202 GOL   D C2    1 ? 
HETATM 2659 O  O2    . GOL   E 5 .   ? 10.611  -6.950  24.103  1.000 33.879 0 202 GOL   D O2    1 ? 
HETATM 2660 C  C3    . GOL   E 5 .   ? 12.230  -7.854  22.629  1.000 28.980 0 202 GOL   D C3    1 ? 
HETATM 2661 O  O3    . GOL   E 5 .   ? 13.478  -7.260  22.955  1.000 33.125 0 202 GOL   D O3    1 ? 
HETATM 2662 O  O     . HOH   F 6 .   ? -9.564  13.000  -1.727  1.000 31.239 0 401 HOH   C O     1 ? 
HETATM 2663 O  O     . HOH   F 6 .   ? 31.193  14.341  -0.881  1.000 35.535 0 402 HOH   C O     1 ? 
HETATM 2664 O  O     . HOH   F 6 .   ? -8.496  20.518  7.744   1.000 37.040 0 403 HOH   C O     1 ? 
HETATM 2665 O  O     . HOH   F 6 .   ? 10.845  12.521  25.002  1.000 26.841 0 404 HOH   C O     1 ? 
HETATM 2666 O  O     . HOH   F 6 .   ? 30.449  15.482  1.818   1.000 27.169 0 405 HOH   C O     1 ? 
HETATM 2667 O  O     . HOH   F 6 .   ? 12.009  3.690   -11.930 1.000 30.829 0 406 HOH   C O     1 ? 
HETATM 2668 O  O     . HOH   F 6 .   ? 27.751  8.216   -2.525  1.000 44.099 0 407 HOH   C O     1 ? 
HETATM 2669 O  O     . HOH   F 6 .   ? 25.523  19.029  5.949   1.000 32.610 0 408 HOH   C O     1 ? 
HETATM 2670 O  O     . HOH   F 6 .   ? -3.856  16.088  -2.320  1.000 47.175 0 409 HOH   C O     1 ? 
HETATM 2671 O  O     . HOH   F 6 .   ? -1.504  9.885   27.861  1.000 38.693 0 410 HOH   C O     1 ? 
HETATM 2672 O  O     . HOH   F 6 .   ? 31.555  0.841   16.697  1.000 44.228 0 411 HOH   C O     1 ? 
HETATM 2673 O  O     . HOH   F 6 .   ? 14.929  14.499  24.137  1.000 28.598 0 412 HOH   C O     1 ? 
HETATM 2674 O  O     . HOH   F 6 .   ? 11.534  17.055  -11.645 1.000 40.044 0 413 HOH   C O     1 ? 
HETATM 2675 O  O     . HOH   F 6 .   ? -4.934  -3.330  12.601  1.000 30.226 0 414 HOH   C O     1 ? 
HETATM 2676 O  O     . HOH   F 6 .   ? 17.395  29.668  4.154   1.000 37.678 0 415 HOH   C O     1 ? 
HETATM 2677 O  O     . HOH   F 6 .   ? -0.623  26.022  22.286  1.000 32.508 0 416 HOH   C O     1 ? 
HETATM 2678 O  O     . HOH   F 6 .   ? 7.636   17.607  3.167   1.000 15.158 0 417 HOH   C O     1 ? 
HETATM 2679 O  O     . HOH   F 6 .   ? 11.222  28.074  21.037  1.000 41.604 0 418 HOH   C O     1 ? 
HETATM 2680 O  O     . HOH   F 6 .   ? -11.628 16.276  17.044  1.000 39.976 0 419 HOH   C O     1 ? 
HETATM 2681 O  O     . HOH   F 6 .   ? 35.327  10.860  7.849   1.000 37.698 0 420 HOH   C O     1 ? 
HETATM 2682 O  O     . HOH   F 6 .   ? 10.467  11.743  -11.999 1.000 23.867 0 421 HOH   C O     1 ? 
HETATM 2683 O  O     . HOH   F 6 .   ? 25.627  1.111   21.080  1.000 36.791 0 422 HOH   C O     1 ? 
HETATM 2684 O  O     . HOH   F 6 .   ? 3.398   18.716  22.945  1.000 21.824 0 423 HOH   C O     1 ? 
HETATM 2685 O  O     . HOH   F 6 .   ? 12.879  30.427  -5.215  1.000 35.100 0 424 HOH   C O     1 ? 
HETATM 2686 O  O     . HOH   F 6 .   ? -0.000  25.927  8.986   1.000 33.464 0 425 HOH   C O     1 ? 
HETATM 2687 O  O     . HOH   F 6 .   ? 14.706  8.386   3.920   1.000 8.791  0 426 HOH   C O     1 ? 
HETATM 2688 O  O     . HOH   F 6 .   ? -5.170  -1.660  3.851   1.000 21.821 0 427 HOH   C O     1 ? 
HETATM 2689 O  O     . HOH   F 6 .   ? 19.790  -3.979  1.422   1.000 45.657 0 428 HOH   C O     1 ? 
HETATM 2690 O  O     . HOH   F 6 .   ? 2.682   34.195  -7.243  1.000 47.209 0 429 HOH   C O     1 ? 
HETATM 2691 O  O     . HOH   F 6 .   ? 19.927  -4.116  -4.139  1.000 48.842 0 430 HOH   C O     1 ? 
HETATM 2692 O  O     . HOH   F 6 .   ? 7.464   -0.743  23.616  1.000 25.662 0 431 HOH   C O     1 ? 
HETATM 2693 O  O     . HOH   F 6 .   ? 29.927  -5.372  -0.500  1.000 35.496 0 432 HOH   C O     1 ? 
HETATM 2694 O  O     . HOH   F 6 .   ? -5.018  11.111  10.630  1.000 23.706 0 433 HOH   C O     1 ? 
HETATM 2695 O  O     . HOH   F 6 .   ? 30.665  12.284  -2.873  1.000 29.326 0 434 HOH   C O     1 ? 
HETATM 2696 O  O     . HOH   F 6 .   ? 26.451  -2.553  20.657  1.000 42.892 0 435 HOH   C O     1 ? 
HETATM 2697 O  O     . HOH   F 6 .   ? 20.373  4.143   -10.579 1.000 39.585 0 436 HOH   C O     1 ? 
HETATM 2698 O  O     . HOH   F 6 .   ? 15.170  6.438   -10.761 1.000 23.253 0 437 HOH   C O     1 ? 
HETATM 2699 O  O     . HOH   F 6 .   ? 18.873  -2.463  -1.503  1.000 31.177 0 438 HOH   C O     1 ? 
HETATM 2700 O  O     . HOH   F 6 .   ? 15.947  -7.826  -0.677  1.000 14.012 0 439 HOH   C O     1 ? 
HETATM 2701 O  O     . HOH   F 6 .   ? 6.877   19.909  1.500   1.000 20.305 0 440 HOH   C O     1 ? 
HETATM 2702 O  O     . HOH   F 6 .   ? 22.390  1.115   21.805  1.000 28.234 0 441 HOH   C O     1 ? 
HETATM 2703 O  O     . HOH   F 6 .   ? 27.334  -3.111  -2.709  1.000 29.594 0 442 HOH   C O     1 ? 
HETATM 2704 O  O     . HOH   F 6 .   ? -11.830 8.558   26.282  1.000 34.484 0 443 HOH   C O     1 ? 
HETATM 2705 O  O     . HOH   F 6 .   ? -6.051  11.755  -2.448  1.000 44.143 0 444 HOH   C O     1 ? 
HETATM 2706 O  O     . HOH   F 6 .   ? -5.712  8.670   6.983   1.000 27.795 0 445 HOH   C O     1 ? 
HETATM 2707 O  O     . HOH   F 6 .   ? 3.538   6.071   -7.968  1.000 19.091 0 446 HOH   C O     1 ? 
HETATM 2708 O  O     . HOH   F 6 .   ? 25.999  21.331  9.257   1.000 24.991 0 447 HOH   C O     1 ? 
HETATM 2709 O  O     . HOH   F 6 .   ? -4.129  28.667  21.705  1.000 32.838 0 448 HOH   C O     1 ? 
HETATM 2710 O  O     . HOH   F 6 .   ? 21.609  12.063  21.731  1.000 19.743 0 449 HOH   C O     1 ? 
HETATM 2711 O  O     . HOH   F 6 .   ? 17.397  16.108  18.197  1.000 25.903 0 450 HOH   C O     1 ? 
HETATM 2712 O  O     . HOH   F 6 .   ? -2.469  12.459  -3.315  1.000 35.122 0 451 HOH   C O     1 ? 
HETATM 2713 O  O     . HOH   F 6 .   ? 9.796   18.931  25.152  1.000 22.782 0 452 HOH   C O     1 ? 
HETATM 2714 O  O     . HOH   F 6 .   ? -3.084  3.065   7.108   1.000 38.060 0 453 HOH   C O     1 ? 
HETATM 2715 O  O     . HOH   F 6 .   ? 28.312  -4.916  3.432   1.000 21.303 0 454 HOH   C O     1 ? 
HETATM 2716 O  O     . HOH   F 6 .   ? 0.310   19.621  6.695   1.000 21.879 0 455 HOH   C O     1 ? 
HETATM 2717 O  O     . HOH   F 6 .   ? -6.069  -0.187  1.549   1.000 32.041 0 456 HOH   C O     1 ? 
HETATM 2718 O  O     . HOH   F 6 .   ? -4.071  21.368  21.100  1.000 32.282 0 457 HOH   C O     1 ? 
HETATM 2719 O  O     . HOH   F 6 .   ? 4.739   3.608   -13.235 1.000 36.790 0 458 HOH   C O     1 ? 
HETATM 2720 O  O     . HOH   F 6 .   ? 0.048   21.842  3.213   1.000 36.188 0 459 HOH   C O     1 ? 
HETATM 2721 O  O     . HOH   F 6 .   ? 8.749   42.073  3.785   1.000 36.449 0 460 HOH   C O     1 ? 
HETATM 2722 O  O     . HOH   F 6 .   ? 2.196   26.629  16.251  1.000 34.816 0 461 HOH   C O     1 ? 
HETATM 2723 O  O     . HOH   F 6 .   ? 1.172   24.455  21.393  1.000 32.764 0 462 HOH   C O     1 ? 
HETATM 2724 O  O     . HOH   F 6 .   ? 19.017  -1.127  21.299  1.000 27.656 0 463 HOH   C O     1 ? 
HETATM 2725 O  O     . HOH   F 6 .   ? 18.805  0.759   -8.419  1.000 21.071 0 464 HOH   C O     1 ? 
HETATM 2726 O  O     . HOH   F 6 .   ? 10.141  40.720  -3.121  1.000 47.595 0 465 HOH   C O     1 ? 
HETATM 2727 O  O     . HOH   F 6 .   ? 12.117  3.416   23.630  1.000 21.092 0 466 HOH   C O     1 ? 
HETATM 2728 O  O     . HOH   F 6 .   ? 7.531   15.625  1.333   1.000 38.485 0 467 HOH   C O     1 ? 
HETATM 2729 O  O     . HOH   F 6 .   ? -2.578  5.412   -4.490  1.000 17.409 0 468 HOH   C O     1 ? 
HETATM 2730 O  O     . HOH   F 6 .   ? 6.920   -0.059  -10.144 1.000 19.444 0 469 HOH   C O     1 ? 
HETATM 2731 O  O     . HOH   F 6 .   ? 17.803  1.089   26.154  1.000 31.082 0 470 HOH   C O     1 ? 
HETATM 2732 O  O     . HOH   F 6 .   ? -1.473  16.398  23.632  1.000 16.352 0 471 HOH   C O     1 ? 
HETATM 2733 O  O     . HOH   F 6 .   ? 11.133  36.241  0.414   1.000 36.457 0 472 HOH   C O     1 ? 
HETATM 2734 O  O     . HOH   F 6 .   ? -0.182  18.640  10.624  1.000 32.562 0 473 HOH   C O     1 ? 
HETATM 2735 O  O     . HOH   F 6 .   ? 9.650   18.136  -5.411  1.000 14.803 0 474 HOH   C O     1 ? 
HETATM 2736 O  O     . HOH   F 6 .   ? 8.098   16.256  7.155   1.000 10.719 0 475 HOH   C O     1 ? 
HETATM 2737 O  O     . HOH   F 6 .   ? 25.381  6.839   -3.288  1.000 37.346 0 476 HOH   C O     1 ? 
HETATM 2738 O  O     . HOH   F 6 .   ? -1.397  -0.954  10.629  1.000 23.544 0 477 HOH   C O     1 ? 
HETATM 2739 O  O     . HOH   F 6 .   ? -5.303  8.045   4.685   1.000 32.720 0 478 HOH   C O     1 ? 
HETATM 2740 O  O     . HOH   F 6 .   ? 11.085  9.799   5.277   1.000 9.511  0 479 HOH   C O     1 ? 
HETATM 2741 O  O     . HOH   F 6 .   ? 2.635   -7.505  16.104  1.000 16.944 0 480 HOH   C O     1 ? 
HETATM 2742 O  O     . HOH   F 6 .   ? 31.881  3.483   11.592  1.000 37.254 0 481 HOH   C O     1 ? 
HETATM 2743 O  O     . HOH   F 6 .   ? 20.663  10.629  -8.152  1.000 19.110 0 482 HOH   C O     1 ? 
HETATM 2744 O  O     . HOH   F 6 .   ? 7.390   28.250  2.723   1.000 21.393 0 483 HOH   C O     1 ? 
HETATM 2745 O  O     . HOH   F 6 .   ? 30.824  5.579   -1.273  1.000 22.660 0 484 HOH   C O     1 ? 
HETATM 2746 O  O     . HOH   F 6 .   ? 13.633  5.237   25.003  1.000 20.174 0 485 HOH   C O     1 ? 
HETATM 2747 O  O     . HOH   F 6 .   ? -5.057  -6.700  6.980   1.000 25.364 0 486 HOH   C O     1 ? 
HETATM 2748 O  O     . HOH   F 6 .   ? 8.845   -7.080  14.152  1.000 16.725 0 487 HOH   C O     1 ? 
HETATM 2749 O  O     . HOH   F 6 .   ? 22.170  13.680  0.864   1.000 10.738 0 488 HOH   C O     1 ? 
HETATM 2750 O  O     . HOH   F 6 .   ? 4.185   20.391  14.910  1.000 14.618 0 489 HOH   C O     1 ? 
HETATM 2751 O  O     . HOH   F 6 .   ? 10.748  29.890  7.880   1.000 35.013 0 490 HOH   C O     1 ? 
HETATM 2752 O  O     . HOH   F 6 .   ? 26.139  12.448  -2.938  1.000 22.532 0 491 HOH   C O     1 ? 
HETATM 2753 O  O     . HOH   F 6 .   ? 20.757  12.166  25.644  1.000 27.228 0 492 HOH   C O     1 ? 
HETATM 2754 O  O     . HOH   F 6 .   ? 22.410  22.414  14.942  1.000 38.902 0 493 HOH   C O     1 ? 
HETATM 2755 O  O     . HOH   F 6 .   ? 5.739   6.366   26.255  1.000 27.648 0 494 HOH   C O     1 ? 
HETATM 2756 O  O     . HOH   F 6 .   ? 6.222   31.255  4.134   1.000 34.781 0 495 HOH   C O     1 ? 
HETATM 2757 O  O     . HOH   F 6 .   ? 16.362  -4.063  21.149  1.000 25.007 0 496 HOH   C O     1 ? 
HETATM 2758 O  O     . HOH   F 6 .   ? 25.053  -0.691  11.575  1.000 27.505 0 497 HOH   C O     1 ? 
HETATM 2759 O  O     . HOH   F 6 .   ? 32.983  10.471  6.226   1.000 33.684 0 498 HOH   C O     1 ? 
HETATM 2760 O  O     . HOH   F 6 .   ? -1.103  0.855   9.017   1.000 39.270 0 499 HOH   C O     1 ? 
HETATM 2761 O  O     . HOH   F 6 .   ? 24.425  -3.877  17.118  1.000 29.563 0 500 HOH   C O     1 ? 
HETATM 2762 O  O     . HOH   F 6 .   ? 28.813  -0.669  4.917   1.000 20.454 0 501 HOH   C O     1 ? 
HETATM 2763 O  O     . HOH   F 6 .   ? -3.320  5.180   14.284  1.000 20.063 0 502 HOH   C O     1 ? 
HETATM 2764 O  O     . HOH   F 6 .   ? 19.241  14.274  21.791  1.000 29.011 0 503 HOH   C O     1 ? 
HETATM 2765 O  O     . HOH   F 6 .   ? 19.513  -4.605  -7.046  1.000 45.897 0 504 HOH   C O     1 ? 
HETATM 2766 O  O     . HOH   F 6 .   ? 14.602  1.672   23.365  1.000 29.571 0 505 HOH   C O     1 ? 
HETATM 2767 O  O     . HOH   F 6 .   ? 2.052   0.011   20.570  1.000 13.083 0 506 HOH   C O     1 ? 
HETATM 2768 O  O     . HOH   F 6 .   ? 5.248   25.138  -3.628  1.000 24.688 0 507 HOH   C O     1 ? 
HETATM 2769 O  O     . HOH   F 6 .   ? 28.209  2.677   4.573   1.000 36.316 0 508 HOH   C O     1 ? 
HETATM 2770 O  O     . HOH   F 6 .   ? 5.014   0.612   23.701  1.000 25.458 0 509 HOH   C O     1 ? 
HETATM 2771 O  O     . HOH   F 6 .   ? 32.175  2.729   -3.296  1.000 35.553 0 510 HOH   C O     1 ? 
HETATM 2772 O  O     . HOH   F 6 .   ? 17.147  5.550   26.246  1.000 32.120 0 511 HOH   C O     1 ? 
HETATM 2773 O  O     . HOH   F 6 .   ? -0.669  28.410  13.118  1.000 36.910 0 512 HOH   C O     1 ? 
HETATM 2774 O  O     . HOH   F 6 .   ? 11.743  27.444  -1.384  1.000 18.075 0 513 HOH   C O     1 ? 
HETATM 2775 O  O     . HOH   F 6 .   ? 5.675   24.676  -0.214  1.000 19.986 0 514 HOH   C O     1 ? 
HETATM 2776 O  O     . HOH   F 6 .   ? -1.752  9.144   -2.879  1.000 30.261 0 515 HOH   C O     1 ? 
HETATM 2777 O  O     . HOH   F 6 .   ? -4.329  13.392  4.634   1.000 26.212 0 516 HOH   C O     1 ? 
HETATM 2778 O  O     . HOH   F 6 .   ? 14.051  18.227  -4.633  1.000 17.363 0 517 HOH   C O     1 ? 
HETATM 2779 O  O     . HOH   F 6 .   ? -1.508  17.094  -1.321  1.000 41.536 0 518 HOH   C O     1 ? 
HETATM 2780 O  O     . HOH   F 6 .   ? 11.791  -1.296  20.862  1.000 19.907 0 519 HOH   C O     1 ? 
HETATM 2781 O  O     . HOH   F 6 .   ? 17.164  23.166  17.444  1.000 36.028 0 520 HOH   C O     1 ? 
HETATM 2782 O  O     . HOH   F 6 .   ? 9.194   28.129  -0.676  1.000 15.348 0 521 HOH   C O     1 ? 
HETATM 2783 O  O     . HOH   F 6 .   ? -1.123  23.698  6.896   1.000 33.967 0 522 HOH   C O     1 ? 
HETATM 2784 O  O     . HOH   F 6 .   ? 18.052  -4.727  -0.224  1.000 33.939 0 523 HOH   C O     1 ? 
HETATM 2785 O  O     . HOH   F 6 .   ? 30.464  0.261   -2.993  1.000 30.103 0 524 HOH   C O     1 ? 
HETATM 2786 O  O     . HOH   F 6 .   ? 14.477  33.782  11.235  1.000 48.738 0 525 HOH   C O     1 ? 
HETATM 2787 O  O     . HOH   F 6 .   ? -2.211  -1.309  15.024  1.000 15.408 0 526 HOH   C O     1 ? 
HETATM 2788 O  O     . HOH   F 6 .   ? 29.920  22.267  12.308  1.000 35.953 0 527 HOH   C O     1 ? 
HETATM 2789 O  O     . HOH   F 6 .   ? 7.657   27.575  8.084   1.000 28.973 0 528 HOH   C O     1 ? 
HETATM 2790 O  O     . HOH   F 6 .   ? -1.669  -6.294  10.127  1.000 10.633 0 529 HOH   C O     1 ? 
HETATM 2791 O  O     . HOH   F 6 .   ? 17.340  17.534  13.181  1.000 20.544 0 530 HOH   C O     1 ? 
HETATM 2792 O  O     . HOH   F 6 .   ? 16.344  -0.373  23.363  1.000 24.100 0 531 HOH   C O     1 ? 
HETATM 2793 O  O     . HOH   F 6 .   ? -2.396  -7.560  5.729   1.000 17.264 0 532 HOH   C O     1 ? 
HETATM 2794 O  O     . HOH   F 6 .   ? -5.185  3.771   5.515   1.000 33.317 0 533 HOH   C O     1 ? 
HETATM 2795 O  O     . HOH   F 6 .   ? 12.851  33.096  2.994   1.000 27.112 0 534 HOH   C O     1 ? 
HETATM 2796 O  O     . HOH   F 6 .   ? -6.927  21.744  15.424  1.000 31.423 0 535 HOH   C O     1 ? 
HETATM 2797 O  O     . HOH   F 6 .   ? 20.078  15.380  1.492   1.000 14.316 0 536 HOH   C O     1 ? 
HETATM 2798 O  O     . HOH   F 6 .   ? 15.969  20.828  20.935  1.000 36.361 0 537 HOH   C O     1 ? 
HETATM 2799 O  O     . HOH   F 6 .   ? -4.435  18.168  9.175   1.000 23.757 0 538 HOH   C O     1 ? 
HETATM 2800 O  O     . HOH   F 6 .   ? 28.907  13.244  18.315  1.000 26.034 0 539 HOH   C O     1 ? 
HETATM 2801 O  O     . HOH   F 6 .   ? 8.669   25.499  22.097  1.000 19.216 0 540 HOH   C O     1 ? 
HETATM 2802 O  O     . HOH   F 6 .   ? 26.799  3.834   19.197  1.000 25.422 0 541 HOH   C O     1 ? 
HETATM 2803 O  O     . HOH   F 6 .   ? 6.564   -8.277  14.457  1.000 17.601 0 542 HOH   C O     1 ? 
HETATM 2804 O  O     . HOH   F 6 .   ? -4.656  5.426   19.188  1.000 32.399 0 543 HOH   C O     1 ? 
HETATM 2805 O  O     . HOH   F 6 .   ? 24.168  6.329   -5.664  1.000 35.941 0 544 HOH   C O     1 ? 
HETATM 2806 O  O     . HOH   F 6 .   ? -6.482  -2.843  1.345   1.000 29.940 0 545 HOH   C O     1 ? 
HETATM 2807 O  O     . HOH   F 6 .   ? -7.569  15.230  -1.610  1.000 20.762 0 546 HOH   C O     1 ? 
HETATM 2808 O  O     . HOH   F 6 .   ? 26.835  2.917   14.547  1.000 26.961 0 547 HOH   C O     1 ? 
HETATM 2809 O  O     . HOH   F 6 .   ? 15.014  15.998  19.968  1.000 43.114 0 548 HOH   C O     1 ? 
HETATM 2810 O  O     . HOH   F 6 .   ? 19.211  9.435   27.240  1.000 31.892 0 549 HOH   C O     1 ? 
HETATM 2811 O  O     . HOH   F 6 .   ? 26.886  4.973   16.782  1.000 25.286 0 550 HOH   C O     1 ? 
HETATM 2812 O  O     . HOH   F 6 .   ? 17.498  23.886  12.362  1.000 24.638 0 551 HOH   C O     1 ? 
HETATM 2813 O  O     . HOH   F 6 .   ? 32.730  8.978   14.148  1.000 27.423 0 552 HOH   C O     1 ? 
HETATM 2814 O  O     . HOH   F 6 .   ? 24.877  -3.485  6.144   1.000 20.706 0 553 HOH   C O     1 ? 
HETATM 2815 O  O     . HOH   F 6 .   ? 9.071   10.664  24.740  1.000 20.375 0 554 HOH   C O     1 ? 
HETATM 2816 O  O     . HOH   F 6 .   ? 9.448   -0.250  -7.338  1.000 20.522 0 555 HOH   C O     1 ? 
HETATM 2817 O  O     . HOH   F 6 .   ? 31.835  7.167   -4.500  1.000 41.465 0 556 HOH   C O     1 ? 
HETATM 2818 O  O     . HOH   F 6 .   ? 14.589  17.588  5.663   1.000 11.181 0 557 HOH   C O     1 ? 
HETATM 2819 O  O     . HOH   F 6 .   ? 21.548  15.045  17.764  1.000 22.168 0 558 HOH   C O     1 ? 
HETATM 2820 O  O     . HOH   F 6 .   ? 33.123  5.896   13.460  1.000 39.272 0 559 HOH   C O     1 ? 
HETATM 2821 O  O     . HOH   F 6 .   ? 15.935  -3.919  -3.394  1.000 32.511 0 560 HOH   C O     1 ? 
HETATM 2822 O  O     . HOH   F 6 .   ? 24.114  -6.346  18.357  1.000 32.461 0 561 HOH   C O     1 ? 
HETATM 2823 O  O     . HOH   F 6 .   ? 16.841  26.919  6.513   1.000 22.589 0 562 HOH   C O     1 ? 
HETATM 2824 O  O     . HOH   F 6 .   ? 5.290   7.889   -9.130  1.000 26.151 0 563 HOH   C O     1 ? 
HETATM 2825 O  O     . HOH   F 6 .   ? -6.420  1.811   3.752   1.000 32.899 0 564 HOH   C O     1 ? 
HETATM 2826 O  O     . HOH   F 6 .   ? 14.074  23.896  -7.008  1.000 28.136 0 565 HOH   C O     1 ? 
HETATM 2827 O  O     . HOH   F 6 .   ? -8.390  12.548  -2.438  1.000 25.391 0 566 HOH   C O     1 ? 
HETATM 2828 O  O     . HOH   F 6 .   ? 28.135  21.103  5.441   1.000 26.179 0 567 HOH   C O     1 ? 
HETATM 2829 O  O     . HOH   F 6 .   ? 3.051   37.097  -4.712  1.000 25.638 0 568 HOH   C O     1 ? 
HETATM 2830 O  O     . HOH   F 6 .   ? 14.504  17.266  23.643  1.000 41.836 0 569 HOH   C O     1 ? 
HETATM 2831 O  O     . HOH   F 6 .   ? 15.870  19.779  -2.848  1.000 10.463 0 570 HOH   C O     1 ? 
HETATM 2832 O  O     . HOH   F 6 .   ? -11.701 16.286  8.351   1.000 29.143 0 571 HOH   C O     1 ? 
HETATM 2833 O  O     . HOH   F 6 .   ? 25.663  11.619  22.873  1.000 44.216 0 572 HOH   C O     1 ? 
HETATM 2834 O  O     . HOH   F 6 .   ? 24.490  4.919   22.437  1.000 37.146 0 573 HOH   C O     1 ? 
HETATM 2835 O  O     . HOH   F 6 .   ? -11.983 13.703  5.015   1.000 23.403 0 574 HOH   C O     1 ? 
HETATM 2836 O  O     . HOH   F 6 .   ? 27.655  9.472   -5.729  1.000 38.047 0 575 HOH   C O     1 ? 
HETATM 2837 O  O     . HOH   F 6 .   ? -6.628  11.900  4.593   1.000 32.115 0 576 HOH   C O     1 ? 
HETATM 2838 O  O     . HOH   F 6 .   ? 17.636  14.362  23.435  1.000 39.205 0 577 HOH   C O     1 ? 
HETATM 2839 O  O     . HOH   F 6 .   ? -7.755  16.966  22.165  1.000 23.035 0 578 HOH   C O     1 ? 
HETATM 2840 O  O     . HOH   F 6 .   ? 24.943  -1.745  8.082   1.000 38.207 0 579 HOH   C O     1 ? 
HETATM 2841 O  O     . HOH   F 6 .   ? 31.038  15.047  15.884  1.000 23.526 0 580 HOH   C O     1 ? 
HETATM 2842 O  O     . HOH   F 6 .   ? 7.824   34.157  -5.657  1.000 35.055 0 581 HOH   C O     1 ? 
HETATM 2843 O  O     . HOH   F 6 .   ? 12.446  7.063   -14.640 1.000 45.818 0 582 HOH   C O     1 ? 
HETATM 2844 O  O     . HOH   F 6 .   ? 4.490   26.931  8.305   1.000 37.527 0 583 HOH   C O     1 ? 
HETATM 2845 O  O     . HOH   F 6 .   ? 24.166  -4.830  20.589  1.000 41.978 0 584 HOH   C O     1 ? 
HETATM 2846 O  O     . HOH   F 6 .   ? 9.178   15.447  -12.229 1.000 26.799 0 585 HOH   C O     1 ? 
HETATM 2847 O  O     . HOH   F 6 .   ? 9.733   21.385  -9.316  1.000 34.766 0 586 HOH   C O     1 ? 
HETATM 2848 O  O     . HOH   F 6 .   ? 21.595  14.600  20.462  1.000 28.946 0 587 HOH   C O     1 ? 
HETATM 2849 O  O     . HOH   F 6 .   ? -8.912  22.712  18.638  1.000 41.449 0 588 HOH   C O     1 ? 
HETATM 2850 O  O     . HOH   F 6 .   ? 19.221  19.681  12.670  1.000 21.775 0 589 HOH   C O     1 ? 
HETATM 2851 O  O     . HOH   F 6 .   ? -4.931  3.944   8.212   1.000 43.115 0 590 HOH   C O     1 ? 
HETATM 2852 O  O     . HOH   F 6 .   ? 7.988   14.512  27.748  1.000 56.410 0 591 HOH   C O     1 ? 
HETATM 2853 O  O     . HOH   F 6 .   ? -4.503  7.439   15.066  1.000 32.279 0 592 HOH   C O     1 ? 
HETATM 2854 O  O     . HOH   F 6 .   ? 4.324   26.518  17.716  1.000 42.076 0 593 HOH   C O     1 ? 
HETATM 2855 O  O     . HOH   F 6 .   ? 27.541  -2.535  6.360   1.000 25.336 0 594 HOH   C O     1 ? 
HETATM 2856 O  O     . HOH   F 6 .   ? 12.648  16.726  24.871  1.000 37.140 0 595 HOH   C O     1 ? 
HETATM 2857 O  O     . HOH   F 6 .   ? 4.874   26.716  2.973   1.000 40.236 0 596 HOH   C O     1 ? 
HETATM 2858 O  O     . HOH   F 6 .   ? -7.489  -3.558  4.791   1.000 37.163 0 597 HOH   C O     1 ? 
HETATM 2859 O  O     . HOH   F 6 .   ? -6.398  -5.383  5.717   1.000 40.240 0 598 HOH   C O     1 ? 
HETATM 2860 O  O     . HOH   F 6 .   ? 4.069   18.049  23.468  1.000 27.452 0 599 HOH   C O     1 ? 
HETATM 2861 O  O     . HOH   F 6 .   ? 32.787  13.216  14.156  1.000 34.718 0 600 HOH   C O     1 ? 
HETATM 2862 O  O     . HOH   F 6 .   ? -7.396  19.206  9.383   1.000 38.675 0 601 HOH   C O     1 ? 
HETATM 2863 O  O     . HOH   F 6 .   ? -5.502  10.064  3.297   1.000 37.269 0 602 HOH   C O     1 ? 
HETATM 2864 O  O     . HOH   F 6 .   ? -5.734  22.525  17.533  1.000 37.765 0 603 HOH   C O     1 ? 
HETATM 2865 O  O     . HOH   F 6 .   ? -5.818  -9.032  5.306   1.000 28.202 0 604 HOH   C O     1 ? 
HETATM 2866 O  O     . HOH   F 6 .   ? 25.920  3.861   -6.727  1.000 55.438 0 605 HOH   C O     1 ? 
HETATM 2867 O  O     . HOH   F 6 .   ? 12.879  10.545  -12.476 1.000 50.692 0 606 HOH   C O     1 ? 
HETATM 2868 O  O     . HOH   F 6 .   ? -1.252  27.875  23.835  1.000 22.824 0 607 HOH   C O     1 ? 
HETATM 2869 O  O     . HOH   F 6 .   ? 33.869  12.810  2.844   1.000 27.986 0 608 HOH   C O     1 ? 
HETATM 2870 O  O     . HOH   F 6 .   ? 25.641  22.756  13.367  1.000 41.785 0 609 HOH   C O     1 ? 
HETATM 2871 O  O     . HOH   F 6 .   ? -4.937  24.452  16.202  1.000 44.379 0 610 HOH   C O     1 ? 
HETATM 2872 O  O     . HOH   F 6 .   ? -4.415  -0.999  13.189  1.000 34.546 0 611 HOH   C O     1 ? 
HETATM 2873 O  O     . HOH   F 6 .   ? -4.247  -5.389  14.312  1.000 23.730 0 612 HOH   C O     1 ? 
HETATM 2874 O  O     . HOH   F 6 .   ? -2.257  10.363  26.180  1.000 31.996 0 613 HOH   C O     1 ? 
HETATM 2875 O  O     . HOH   F 6 .   ? 12.519  -0.070  23.660  1.000 36.990 0 614 HOH   C O     1 ? 
HETATM 2876 O  O     . HOH   F 6 .   ? 18.559  26.203  11.119  1.000 34.681 0 615 HOH   C O     1 ? 
HETATM 2877 O  O     . HOH   F 6 .   ? 27.079  15.066  19.394  1.000 38.173 0 616 HOH   C O     1 ? 
HETATM 2878 O  O     . HOH   F 6 .   ? 4.994   -9.038  16.781  1.000 18.882 0 617 HOH   C O     1 ? 
HETATM 2879 O  O     . HOH   F 6 .   ? -2.829  23.941  12.432  1.000 27.066 0 618 HOH   C O     1 ? 
HETATM 2880 O  O     . HOH   F 6 .   ? -0.400  29.555  19.307  1.000 37.373 0 619 HOH   C O     1 ? 
HETATM 2881 O  O     . HOH   F 6 .   ? -3.116  18.791  24.210  1.000 32.244 0 620 HOH   C O     1 ? 
HETATM 2882 O  O     . HOH   F 6 .   ? 5.816   26.922  23.359  1.000 29.776 0 621 HOH   C O     1 ? 
HETATM 2883 O  O     . HOH   F 6 .   ? -8.083  22.230  12.743  1.000 39.990 0 622 HOH   C O     1 ? 
HETATM 2884 O  O     . HOH   F 6 .   ? 9.010   12.342  -13.562 1.000 31.758 0 623 HOH   C O     1 ? 
HETATM 2885 O  O     . HOH   F 6 .   ? 26.580  21.166  2.820   1.000 31.215 0 624 HOH   C O     1 ? 
HETATM 2886 O  O     . HOH   F 6 .   ? 19.395  30.403  1.782   1.000 55.305 0 625 HOH   C O     1 ? 
HETATM 2887 O  O     . HOH   F 6 .   ? 18.937  22.213  11.577  1.000 28.089 0 626 HOH   C O     1 ? 
HETATM 2888 O  O     . HOH   F 6 .   ? 4.659   -3.206  22.389  1.000 41.809 0 627 HOH   C O     1 ? 
HETATM 2889 O  O     . HOH   F 6 .   ? 2.115   -9.023  13.887  1.000 13.096 0 628 HOH   C O     1 ? 
HETATM 2890 O  O     . HOH   F 6 .   ? -2.189  20.838  7.211   1.000 26.357 0 629 HOH   C O     1 ? 
HETATM 2891 O  O     . HOH   F 6 .   ? 30.276  -2.901  -3.301  1.000 39.085 0 630 HOH   C O     1 ? 
HETATM 2892 O  O     . HOH   F 6 .   ? 27.501  -0.417  -6.111  1.000 38.998 0 631 HOH   C O     1 ? 
HETATM 2893 O  O     . HOH   F 6 .   ? -0.625  20.447  24.846  1.000 23.615 0 632 HOH   C O     1 ? 
HETATM 2894 O  O     . HOH   F 6 .   ? 28.788  18.039  16.492  1.000 33.250 0 633 HOH   C O     1 ? 
HETATM 2895 O  O     . HOH   F 6 .   ? 19.710  20.629  15.146  1.000 33.920 0 634 HOH   C O     1 ? 
HETATM 2896 O  O     . HOH   F 6 .   ? 14.602  8.837   -11.554 1.000 30.344 0 635 HOH   C O     1 ? 
HETATM 2897 O  O     . HOH   F 6 .   ? 2.463   -2.829  20.529  1.000 22.907 0 636 HOH   C O     1 ? 
HETATM 2898 O  O     . HOH   F 6 .   ? 6.211   27.531  17.085  1.000 44.864 0 637 HOH   C O     1 ? 
HETATM 2899 O  O     . HOH   F 6 .   ? 21.721  4.413   25.405  1.000 37.248 0 638 HOH   C O     1 ? 
HETATM 2900 O  O     . HOH   F 6 .   ? 1.547   26.221  18.777  1.000 37.219 0 639 HOH   C O     1 ? 
HETATM 2901 O  O     . HOH   F 6 .   ? 27.297  21.248  12.028  1.000 34.200 0 640 HOH   C O     1 ? 
HETATM 2902 O  O     . HOH   F 6 .   ? 17.348  17.482  16.022  1.000 26.854 0 641 HOH   C O     1 ? 
HETATM 2903 O  O     . HOH   F 6 .   ? 27.596  -5.981  0.936   1.000 26.932 0 642 HOH   C O     1 ? 
HETATM 2904 O  O     . HOH   F 6 .   ? -0.815  24.890  23.928  1.000 35.259 0 643 HOH   C O     1 ? 
HETATM 2905 O  O     . HOH   F 6 .   ? -9.549  14.715  8.400   1.000 47.672 0 644 HOH   C O     1 ? 
HETATM 2906 O  O     . HOH   F 6 .   ? 22.132  12.491  -8.278  1.000 33.613 0 645 HOH   C O     1 ? 
HETATM 2907 O  O     . HOH   F 6 .   ? 14.005  27.595  14.925  1.000 41.052 0 646 HOH   C O     1 ? 
HETATM 2908 O  O     . HOH   F 6 .   ? 2.560   41.839  3.395   1.000 38.866 0 647 HOH   C O     1 ? 
HETATM 2909 O  O     . HOH   F 6 .   ? 26.098  -4.425  -0.859  1.000 30.382 0 648 HOH   C O     1 ? 
HETATM 2910 O  O     . HOH   F 6 .   ? -0.263  11.505  -3.909  1.000 32.176 0 649 HOH   C O     1 ? 
HETATM 2911 O  O     . HOH   F 6 .   ? -13.632 15.302  6.575   1.000 26.588 0 650 HOH   C O     1 ? 
HETATM 2912 O  O     . HOH   F 6 .   ? 0.379   34.011  -6.759  1.000 33.852 0 651 HOH   C O     1 ? 
HETATM 2913 O  O     . HOH   F 6 .   ? -2.524  19.636  9.930   1.000 26.673 0 652 HOH   C O     1 ? 
HETATM 2914 O  O     . HOH   F 6 .   ? 34.828  20.603  12.213  1.000 39.962 0 653 HOH   C O     1 ? 
HETATM 2915 O  O     . HOH   F 6 .   ? 3.895   36.543  -7.332  1.000 42.680 0 654 HOH   C O     1 ? 
HETATM 2916 O  O     . HOH   F 6 .   ? 24.574  19.647  16.007  1.000 46.543 0 655 HOH   C O     1 ? 
HETATM 2917 O  O     . HOH   F 6 .   ? 20.604  30.073  8.838   1.000 39.228 0 656 HOH   C O     1 ? 
HETATM 2918 O  O     . HOH   F 6 .   ? 27.229  -0.215  8.633   1.000 31.761 0 657 HOH   C O     1 ? 
HETATM 2919 O  O     . HOH   F 6 .   ? -3.309  0.619   16.443  1.000 32.401 0 658 HOH   C O     1 ? 
HETATM 2920 O  O     . HOH   F 6 .   ? -9.502  -7.113  2.602   1.000 23.977 0 659 HOH   C O     1 ? 
HETATM 2921 O  O     . HOH   F 6 .   ? -3.301  21.789  11.042  1.000 30.669 0 660 HOH   C O     1 ? 
HETATM 2922 O  O     . HOH   F 6 .   ? -11.513 12.973  11.728  1.000 37.135 0 661 HOH   C O     1 ? 
HETATM 2923 O  O     . HOH   F 6 .   ? 30.092  1.760   12.491  1.000 38.891 0 662 HOH   C O     1 ? 
HETATM 2924 O  O     . HOH   F 6 .   ? 28.124  1.714   20.257  1.000 30.943 0 663 HOH   C O     1 ? 
HETATM 2925 O  O     . HOH   F 6 .   ? 5.199   24.051  3.066   1.000 55.498 0 664 HOH   C O     1 ? 
HETATM 2926 O  O     . HOH   F 6 .   ? -1.309  -1.813  21.311  1.000 30.861 0 665 HOH   C O     1 ? 
HETATM 2927 O  O     . HOH   F 6 .   ? 22.088  20.848  3.267   1.000 32.768 0 666 HOH   C O     1 ? 
HETATM 2928 O  O     . HOH   F 6 .   ? -3.439  13.951  26.695  1.000 31.561 0 667 HOH   C O     1 ? 
HETATM 2929 O  O     . HOH   F 6 .   ? 2.482   -0.102  24.795  1.000 43.242 0 668 HOH   C O     1 ? 
HETATM 2930 O  O     . HOH   F 6 .   ? 3.065   12.631  -9.080  1.000 32.249 0 669 HOH   C O     1 ? 
HETATM 2931 O  O     . HOH   F 6 .   ? 18.458  30.637  -0.522  1.000 39.727 0 670 HOH   C O     1 ? 
HETATM 2932 O  O     . HOH   F 6 .   ? 10.711  1.547   25.213  1.000 32.776 0 671 HOH   C O     1 ? 
HETATM 2933 O  O     . HOH   F 6 .   ? 0.985   7.404   -7.432  1.000 28.258 0 672 HOH   C O     1 ? 
HETATM 2934 O  O     . HOH   F 6 .   ? 6.117   43.655  6.697   1.000 35.219 0 673 HOH   C O     1 ? 
HETATM 2935 O  O     . HOH   F 6 .   ? 21.699  17.954  17.658  1.000 26.750 0 674 HOH   C O     1 ? 
HETATM 2936 O  O     . HOH   F 6 .   ? 18.312  21.322  18.487  1.000 36.373 0 675 HOH   C O     1 ? 
HETATM 2937 O  O     . HOH   F 6 .   ? 6.286   40.573  -6.326  1.000 50.730 0 676 HOH   C O     1 ? 
HETATM 2938 O  O     . HOH   F 6 .   ? 19.058  18.965  17.047  1.000 36.635 0 677 HOH   C O     1 ? 
HETATM 2939 O  O     . HOH   F 6 .   ? 3.798   10.141  -9.919  1.000 28.871 0 678 HOH   C O     1 ? 
HETATM 2940 O  O     . HOH   G 6 .   ? 14.640  -22.057 24.291  1.000 33.829 0 301 HOH   D O     1 ? 
HETATM 2941 O  O     . HOH   G 6 .   ? 12.358  -23.125 22.705  1.000 34.535 0 302 HOH   D O     1 ? 
HETATM 2942 O  O     . HOH   G 6 .   ? 25.382  -20.646 23.622  1.000 34.645 0 303 HOH   D O     1 ? 
HETATM 2943 O  O     . HOH   G 6 .   ? 28.091  -20.721 19.757  1.000 40.490 0 304 HOH   D O     1 ? 
HETATM 2944 O  O     . HOH   G 6 .   ? 12.714  -16.641 25.824  1.000 45.185 0 305 HOH   D O     1 ? 
HETATM 2945 O  O     . HOH   G 6 .   ? 5.873   -24.002 13.785  1.000 31.023 0 306 HOH   D O     1 ? 
HETATM 2946 O  O     . HOH   G 6 .   ? 24.969  -16.415 24.971  1.000 53.719 0 307 HOH   D O     1 ? 
HETATM 2947 O  O     . HOH   G 6 .   ? -6.831  1.146   -9.317  1.000 30.460 0 308 HOH   D O     1 ? 
HETATM 2948 O  O     . HOH   G 6 .   ? -1.732  3.465   -8.479  1.000 19.672 0 309 HOH   D O     1 ? 
HETATM 2949 O  O     . HOH   G 6 .   ? 3.899   -19.001 -9.752  1.000 39.260 0 310 HOH   D O     1 ? 
HETATM 2950 O  O     . HOH   G 6 .   ? 24.091  -10.750 -3.445  1.000 37.078 0 311 HOH   D O     1 ? 
HETATM 2951 O  O     . HOH   G 6 .   ? 28.157  -11.184 14.064  1.000 32.679 0 312 HOH   D O     1 ? 
HETATM 2952 O  O     . HOH   G 6 .   ? -5.893  -11.549 5.337   1.000 22.899 0 313 HOH   D O     1 ? 
HETATM 2953 O  O     . HOH   G 6 .   ? 5.970   -8.160  19.134  1.000 31.475 0 314 HOH   D O     1 ? 
HETATM 2954 O  O     . HOH   G 6 .   ? 5.899   -26.117 11.827  1.000 42.996 0 315 HOH   D O     1 ? 
HETATM 2955 O  O     . HOH   G 6 .   ? -10.357 -17.543 11.853  1.000 36.949 0 316 HOH   D O     1 ? 
HETATM 2956 O  O     . HOH   G 6 .   ? -4.591  -9.686  3.082   1.000 14.811 0 317 HOH   D O     1 ? 
HETATM 2957 O  O     . HOH   G 6 .   ? 25.932  -16.087 4.930   1.000 18.463 0 318 HOH   D O     1 ? 
HETATM 2958 O  O     . HOH   G 6 .   ? 15.596  -13.869 3.469   1.000 8.552  0 319 HOH   D O     1 ? 
HETATM 2959 O  O     . HOH   G 6 .   ? 13.449  -13.438 21.932  1.000 36.401 0 320 HOH   D O     1 ? 
HETATM 2960 O  O     . HOH   G 6 .   ? 24.551  -24.320 20.664  1.000 37.053 0 321 HOH   D O     1 ? 
HETATM 2961 O  O     . HOH   G 6 .   ? -2.186  -16.471 0.687   1.000 28.782 0 322 HOH   D O     1 ? 
HETATM 2962 O  O     . HOH   G 6 .   ? 1.108   -3.542  -8.040  1.000 12.435 0 323 HOH   D O     1 ? 
HETATM 2963 O  O     . HOH   G 6 .   ? 14.078  -19.733 25.135  1.000 43.951 0 324 HOH   D O     1 ? 
HETATM 2964 O  O     . HOH   G 6 .   ? -6.442  -16.486 18.115  1.000 18.980 0 325 HOH   D O     1 ? 
HETATM 2965 O  O     . HOH   G 6 .   ? -6.160  -9.172  16.405  1.000 28.195 0 326 HOH   D O     1 ? 
HETATM 2966 O  O     . HOH   G 6 .   ? -0.930  -5.533  -8.846  1.000 17.253 0 327 HOH   D O     1 ? 
HETATM 2967 O  O     . HOH   G 6 .   ? 22.801  -26.009 18.307  1.000 49.889 0 328 HOH   D O     1 ? 
HETATM 2968 O  O     . HOH   G 6 .   ? -7.111  -13.599 14.870  1.000 19.682 0 329 HOH   D O     1 ? 
HETATM 2969 O  O     . HOH   G 6 .   ? 0.068   -6.962  6.999   1.000 9.361  0 330 HOH   D O     1 ? 
HETATM 2970 O  O     . HOH   G 6 .   ? -7.019  -7.787  1.618   1.000 19.106 0 331 HOH   D O     1 ? 
HETATM 2971 O  O     . HOH   G 6 .   ? 11.371  -25.933 2.955   1.000 12.638 0 332 HOH   D O     1 ? 
HETATM 2972 O  O     . HOH   G 6 .   ? 16.441  -8.700  -11.903 1.000 18.853 0 333 HOH   D O     1 ? 
HETATM 2973 O  O     . HOH   G 6 .   ? 11.732  -13.237 -14.089 1.000 36.445 0 334 HOH   D O     1 ? 
HETATM 2974 O  O     . HOH   G 6 .   ? -3.966  -10.151 20.152  1.000 20.345 0 335 HOH   D O     1 ? 
HETATM 2975 O  O     . HOH   G 6 .   ? 26.405  -13.427 7.577   1.000 21.813 0 336 HOH   D O     1 ? 
HETATM 2976 O  O     . HOH   G 6 .   ? 16.337  -25.579 -7.742  1.000 42.248 0 337 HOH   D O     1 ? 
HETATM 2977 O  O     . HOH   G 6 .   ? -1.099  -7.539  -11.330 1.000 39.238 0 338 HOH   D O     1 ? 
HETATM 2978 O  O     . HOH   G 6 .   ? 1.705   -11.772 14.102  1.000 16.325 0 339 HOH   D O     1 ? 
HETATM 2979 O  O     . HOH   G 6 .   ? 21.334  -25.023 9.395   1.000 36.741 0 340 HOH   D O     1 ? 
HETATM 2980 O  O     . HOH   G 6 .   ? 3.241   -23.451 6.531   1.000 24.106 0 341 HOH   D O     1 ? 
HETATM 2981 O  O     . HOH   G 6 .   ? 23.134  -6.447  10.294  1.000 15.083 0 342 HOH   D O     1 ? 
HETATM 2982 O  O     . HOH   G 6 .   ? 20.321  -5.986  0.025   1.000 26.866 0 343 HOH   D O     1 ? 
HETATM 2983 O  O     . HOH   G 6 .   ? 3.479   -13.396 7.890   1.000 16.192 0 344 HOH   D O     1 ? 
HETATM 2984 O  O     . HOH   G 6 .   ? -9.023  -10.840 13.343  1.000 30.029 0 345 HOH   D O     1 ? 
HETATM 2985 O  O     . HOH   G 6 .   ? 5.421   -11.268 11.684  1.000 13.172 0 346 HOH   D O     1 ? 
HETATM 2986 O  O     . HOH   G 6 .   ? 11.009  -27.738 7.319   1.000 16.731 0 347 HOH   D O     1 ? 
HETATM 2987 O  O     . HOH   G 6 .   ? -10.712 -15.249 8.097   1.000 31.169 0 348 HOH   D O     1 ? 
HETATM 2988 O  O     . HOH   G 6 .   ? 16.564  -20.491 -3.992  1.000 33.140 0 349 HOH   D O     1 ? 
HETATM 2989 O  O     . HOH   G 6 .   ? 26.652  -8.584  1.060   1.000 21.664 0 350 HOH   D O     1 ? 
HETATM 2990 O  O     . HOH   G 6 .   ? -6.238  -16.231 14.426  1.000 48.227 0 351 HOH   D O     1 ? 
HETATM 2991 O  O     . HOH   G 6 .   ? -2.160  -10.843 2.943   1.000 14.000 0 352 HOH   D O     1 ? 
HETATM 2992 O  O     . HOH   G 6 .   ? 9.733   -24.578 4.697   1.000 14.682 0 353 HOH   D O     1 ? 
HETATM 2993 O  O     . HOH   G 6 .   ? 25.686  -21.536 20.629  1.000 39.932 0 354 HOH   D O     1 ? 
HETATM 2994 O  O     . HOH   G 6 .   ? 23.914  -22.238 10.666  1.000 16.011 0 355 HOH   D O     1 ? 
HETATM 2995 O  O     . HOH   G 6 .   ? -13.671 -16.128 18.379  1.000 36.230 0 356 HOH   D O     1 ? 
HETATM 2996 O  O     . HOH   G 6 .   ? 3.901   -12.911 15.195  1.000 26.400 0 357 HOH   D O     1 ? 
HETATM 2997 O  O     . HOH   G 6 .   ? 2.377   -21.431 -1.296  1.000 20.762 0 358 HOH   D O     1 ? 
HETATM 2998 O  O     . HOH   G 6 .   ? 21.137  -10.237 11.950  1.000 11.759 0 359 HOH   D O     1 ? 
HETATM 2999 O  O     . HOH   G 6 .   ? -7.545  -4.238  -1.341  1.000 27.493 0 360 HOH   D O     1 ? 
HETATM 3000 O  O     . HOH   G 6 .   ? 17.967  -10.367 21.939  1.000 16.804 0 361 HOH   D O     1 ? 
HETATM 3001 O  O     . HOH   G 6 .   ? 0.879   -17.323 -6.049  1.000 15.532 0 362 HOH   D O     1 ? 
HETATM 3002 O  O     . HOH   G 6 .   ? 3.509   -17.460 3.040   1.000 13.115 0 363 HOH   D O     1 ? 
HETATM 3003 O  O     . HOH   G 6 .   ? 16.375  -2.150  -6.331  1.000 31.818 0 364 HOH   D O     1 ? 
HETATM 3004 O  O     . HOH   G 6 .   ? -1.375  -19.205 0.017   1.000 24.213 0 365 HOH   D O     1 ? 
HETATM 3005 O  O     . HOH   G 6 .   ? -9.838  -12.717 4.820   1.000 23.435 0 366 HOH   D O     1 ? 
HETATM 3006 O  O     . HOH   G 6 .   ? -2.561  -16.933 1.655   1.000 21.755 0 367 HOH   D O     1 ? 
HETATM 3007 O  O     . HOH   G 6 .   ? -6.958  -2.587  -11.198 1.000 37.150 0 368 HOH   D O     1 ? 
HETATM 3008 O  O     . HOH   G 6 .   ? 11.435  -20.190 -6.404  1.000 28.320 0 369 HOH   D O     1 ? 
HETATM 3009 O  O     . HOH   G 6 .   ? -1.000  -13.431 8.421   1.000 23.295 0 370 HOH   D O     1 ? 
HETATM 3010 O  O     . HOH   G 6 .   ? 11.061  -10.425 21.165  1.000 24.623 0 371 HOH   D O     1 ? 
HETATM 3011 O  O     . HOH   G 6 .   ? 8.328   -10.657 21.373  1.000 30.999 0 372 HOH   D O     1 ? 
HETATM 3012 O  O     . HOH   G 6 .   ? -8.598  -10.423 16.318  1.000 27.181 0 373 HOH   D O     1 ? 
HETATM 3013 O  O     . HOH   G 6 .   ? 27.101  -20.304 13.878  1.000 38.018 0 374 HOH   D O     1 ? 
HETATM 3014 O  O     . HOH   G 6 .   ? 0.021   -12.180 16.538  1.000 21.812 0 375 HOH   D O     1 ? 
HETATM 3015 O  O     . HOH   G 6 .   ? 26.381  -14.186 -1.999  1.000 22.301 0 376 HOH   D O     1 ? 
HETATM 3016 O  O     . HOH   G 6 .   ? 5.226   -22.860 -5.003  1.000 38.262 0 377 HOH   D O     1 ? 
HETATM 3017 O  O     . HOH   G 6 .   ? 12.043  -3.288  -12.786 1.000 31.568 0 378 HOH   D O     1 ? 
HETATM 3018 O  O     . HOH   G 6 .   ? 26.576  -15.589 8.928   1.000 20.850 0 379 HOH   D O     1 ? 
HETATM 3019 O  O     . HOH   G 6 .   ? -1.425  -14.086 11.924  1.000 22.281 0 380 HOH   D O     1 ? 
HETATM 3020 O  O     . HOH   G 6 .   ? 4.878   -23.810 0.446   1.000 25.675 0 381 HOH   D O     1 ? 
HETATM 3021 O  O     . HOH   G 6 .   ? -0.798  -8.795  3.832   1.000 18.093 0 382 HOH   D O     1 ? 
HETATM 3022 O  O     . HOH   G 6 .   ? 1.513   -3.422  -10.669 1.000 21.785 0 383 HOH   D O     1 ? 
HETATM 3023 O  O     . HOH   G 6 .   ? 20.703  -24.757 12.847  1.000 40.088 0 384 HOH   D O     1 ? 
HETATM 3024 O  O     . HOH   G 6 .   ? 24.198  -8.983  18.446  1.000 28.351 0 385 HOH   D O     1 ? 
HETATM 3025 O  O     . HOH   G 6 .   ? -5.856  -20.931 12.910  1.000 38.575 0 386 HOH   D O     1 ? 
HETATM 3026 O  O     . HOH   G 6 .   ? -1.701  -21.680 16.398  1.000 17.845 0 387 HOH   D O     1 ? 
HETATM 3027 O  O     . HOH   G 6 .   ? 13.558  -25.953 14.914  1.000 49.618 0 388 HOH   D O     1 ? 
HETATM 3028 O  O     . HOH   G 6 .   ? 4.263   -18.001 0.474   1.000 13.320 0 389 HOH   D O     1 ? 
HETATM 3029 O  O     . HOH   G 6 .   ? 23.527  -17.621 20.983  1.000 32.672 0 390 HOH   D O     1 ? 
HETATM 3030 O  O     . HOH   G 6 .   ? 16.514  -31.484 2.715   1.000 35.681 0 391 HOH   D O     1 ? 
HETATM 3031 O  O     . HOH   G 6 .   ? -1.336  -18.846 2.535   1.000 33.034 0 392 HOH   D O     1 ? 
HETATM 3032 O  O     . HOH   G 6 .   ? 23.515  -14.587 -5.317  1.000 16.241 0 393 HOH   D O     1 ? 
HETATM 3033 O  O     . HOH   G 6 .   ? 12.835  -18.894 -13.032 1.000 38.681 0 394 HOH   D O     1 ? 
HETATM 3034 O  O     . HOH   G 6 .   ? 12.482  -27.552 4.928   1.000 12.690 0 395 HOH   D O     1 ? 
HETATM 3035 O  O     . HOH   G 6 .   ? 9.066   -23.816 -5.624  1.000 40.925 0 396 HOH   D O     1 ? 
HETATM 3036 O  O     . HOH   G 6 .   ? 8.126   -15.040 5.815   1.000 8.527  0 397 HOH   D O     1 ? 
HETATM 3037 O  O     . HOH   G 6 .   ? -2.919  -15.876 -1.532  1.000 18.576 0 398 HOH   D O     1 ? 
HETATM 3038 O  O     . HOH   G 6 .   ? 2.497   1.134   -10.177 1.000 21.287 0 399 HOH   D O     1 ? 
HETATM 3039 O  O     . HOH   G 6 .   ? -7.214  4.151   -4.300  1.000 39.535 0 400 HOH   D O     1 ? 
HETATM 3040 O  O     . HOH   G 6 .   ? 20.952  -8.757  -7.888  1.000 50.783 0 401 HOH   D O     1 ? 
HETATM 3041 O  O     . HOH   G 6 .   ? -8.456  -11.505 9.510   1.000 43.006 0 402 HOH   D O     1 ? 
HETATM 3042 O  O     . HOH   G 6 .   ? 14.053  -18.723 -8.847  1.000 36.537 0 403 HOH   D O     1 ? 
HETATM 3043 O  O     . HOH   G 6 .   ? 0.517   -24.618 -6.629  1.000 31.809 0 404 HOH   D O     1 ? 
HETATM 3044 O  O     . HOH   G 6 .   ? 16.380  -11.445 -14.870 1.000 37.530 0 405 HOH   D O     1 ? 
HETATM 3045 O  O     . HOH   G 6 .   ? 1.776   -21.458 -8.091  1.000 34.350 0 406 HOH   D O     1 ? 
HETATM 3046 O  O     . HOH   G 6 .   ? 3.530   -23.201 -7.505  1.000 49.334 0 407 HOH   D O     1 ? 
HETATM 3047 O  O     . HOH   G 6 .   ? -0.775  -17.090 18.043  1.000 19.458 0 408 HOH   D O     1 ? 
HETATM 3048 O  O     . HOH   G 6 .   ? 25.608  -19.031 21.413  1.000 54.697 0 409 HOH   D O     1 ? 
HETATM 3049 O  O     . HOH   G 6 .   ? 8.719   -25.776 -4.147  1.000 38.878 0 410 HOH   D O     1 ? 
HETATM 3050 O  O     . HOH   G 6 .   ? 19.944  -10.978 -13.167 1.000 33.153 0 411 HOH   D O     1 ? 
HETATM 3051 O  O     . HOH   G 6 .   ? 17.209  -6.614  -3.099  1.000 27.436 0 412 HOH   D O     1 ? 
HETATM 3052 O  O     . HOH   G 6 .   ? 17.990  -5.518  -4.992  1.000 33.445 0 413 HOH   D O     1 ? 
HETATM 3053 O  O     . HOH   G 6 .   ? -3.055  -22.158 15.428  1.000 41.265 0 414 HOH   D O     1 ? 
HETATM 3054 O  O     . HOH   G 6 .   ? -4.318  -4.460  -13.092 1.000 50.179 0 415 HOH   D O     1 ? 
HETATM 3055 O  O     . HOH   G 6 .   ? 24.530  -4.116  14.367  1.000 28.168 0 416 HOH   D O     1 ? 
HETATM 3056 O  O     . HOH   G 6 .   ? 27.309  -21.455 15.767  1.000 56.764 0 417 HOH   D O     1 ? 
HETATM 3057 O  O     . HOH   G 6 .   ? 18.153  -16.483 27.620  1.000 40.243 0 418 HOH   D O     1 ? 
HETATM 3058 O  O     . HOH   G 6 .   ? 30.541  -17.520 10.557  1.000 27.187 0 419 HOH   D O     1 ? 
HETATM 3059 O  O     . HOH   G 6 .   ? -6.713  -10.550 11.176  1.000 36.202 0 420 HOH   D O     1 ? 
HETATM 3060 O  O     . HOH   G 6 .   ? 2.999   -15.680 15.322  1.000 33.178 0 421 HOH   D O     1 ? 
HETATM 3061 O  O     . HOH   G 6 .   ? 18.195  -2.805  -10.499 1.000 38.552 0 422 HOH   D O     1 ? 
HETATM 3062 O  O     . HOH   G 6 .   ? 4.301   -11.540 17.578  1.000 32.501 0 423 HOH   D O     1 ? 
HETATM 3063 O  O     . HOH   G 6 .   ? -0.082  -23.061 1.929   1.000 30.748 0 424 HOH   D O     1 ? 
HETATM 3064 O  O     . HOH   G 6 .   ? 25.314  -16.894 2.427   1.000 19.794 0 425 HOH   D O     1 ? 
HETATM 3065 O  O     . HOH   G 6 .   ? 29.257  -16.435 8.299   1.000 21.519 0 426 HOH   D O     1 ? 
HETATM 3066 O  O     . HOH   G 6 .   ? 3.703   -2.867  -12.172 1.000 34.872 0 427 HOH   D O     1 ? 
HETATM 3067 O  O     . HOH   G 6 .   ? 0.428   -15.885 13.673  1.000 41.097 0 428 HOH   D O     1 ? 
HETATM 3068 O  O     . HOH   G 6 .   ? 28.302  -9.092  5.119   1.000 31.740 0 429 HOH   D O     1 ? 
HETATM 3069 O  O     . HOH   G 6 .   ? 17.890  -5.538  -8.905  1.000 34.892 0 430 HOH   D O     1 ? 
HETATM 3070 O  O     . HOH   G 6 .   ? 5.174   -25.345 4.947   1.000 35.815 0 431 HOH   D O     1 ? 
HETATM 3071 O  O     . HOH   G 6 .   ? -1.192  5.656   -6.786  1.000 22.022 0 432 HOH   D O     1 ? 
HETATM 3072 O  O     . HOH   G 6 .   ? 7.606   -6.108  -12.694 1.000 39.921 0 433 HOH   D O     1 ? 
HETATM 3073 O  O     . HOH   G 6 .   ? 13.992  -30.820 7.016   1.000 40.780 0 434 HOH   D O     1 ? 
HETATM 3074 O  O     . HOH   G 6 .   ? 2.805   -9.569  -11.408 1.000 29.402 0 435 HOH   D O     1 ? 
HETATM 3075 O  O     . HOH   G 6 .   ? -5.290  6.325   -5.024  1.000 36.170 0 436 HOH   D O     1 ? 
HETATM 3076 O  O     . HOH   G 6 .   ? 14.388  -28.440 -2.736  1.000 38.259 0 437 HOH   D O     1 ? 
HETATM 3077 O  O     . HOH   G 6 .   ? 0.638   -22.944 5.722   1.000 40.056 0 438 HOH   D O     1 ? 
HETATM 3078 O  O     . HOH   G 6 .   ? 17.872  -33.956 5.870   1.000 42.285 0 439 HOH   D O     1 ? 
HETATM 3079 O  O     . HOH   G 6 .   ? 26.052  -22.076 12.522  1.000 27.793 0 440 HOH   D O     1 ? 
HETATM 3080 O  O     . HOH   G 6 .   ? 25.028  -16.297 19.266  1.000 48.266 0 441 HOH   D O     1 ? 
HETATM 3081 O  O     . HOH   G 6 .   ? -3.489  3.968   -10.647 1.000 41.638 0 442 HOH   D O     1 ? 
HETATM 3082 O  O     . HOH   G 6 .   ? 6.728   -18.319 -10.681 1.000 32.245 0 443 HOH   D O     1 ? 
HETATM 3083 O  O     . HOH   G 6 .   ? -4.963  -19.953 8.031   1.000 30.380 0 444 HOH   D O     1 ? 
HETATM 3084 O  O     . HOH   G 6 .   ? 8.529   -28.111 7.473   1.000 42.652 0 445 HOH   D O     1 ? 
HETATM 3085 O  O     . HOH   G 6 .   ? 25.645  -16.202 -4.321  1.000 23.637 0 446 HOH   D O     1 ? 
HETATM 3086 O  O     . HOH   G 6 .   ? 0.879   -5.631  -11.997 1.000 27.400 0 447 HOH   D O     1 ? 
HETATM 3087 O  O     . HOH   G 6 .   ? 18.284  -7.361  -10.909 1.000 37.310 0 448 HOH   D O     1 ? 
HETATM 3088 O  O     . HOH   G 6 .   ? -7.007  -1.496  -0.650  1.000 36.424 0 449 HOH   D O     1 ? 
HETATM 3089 O  O     . HOH   G 6 .   ? 18.271  -25.193 14.335  1.000 43.546 0 450 HOH   D O     1 ? 
HETATM 3090 O  O     . HOH   G 6 .   ? 27.021  -24.672 12.971  1.000 31.522 0 451 HOH   D O     1 ? 
HETATM 3091 O  O     . HOH   G 6 .   ? 13.061  -29.844 0.736   1.000 40.985 0 452 HOH   D O     1 ? 
HETATM 3092 O  O     . HOH   G 6 .   ? 6.557   -12.427 22.000  1.000 38.222 0 453 HOH   D O     1 ? 
HETATM 3093 O  O     . HOH   G 6 .   ? 0.347   2.751   -10.192 1.000 23.304 0 454 HOH   D O     1 ? 
HETATM 3094 O  O     . HOH   G 6 .   ? 9.580   -0.593  -11.017 1.000 27.035 0 455 HOH   D O     1 ? 
HETATM 3095 O  O     . HOH   G 6 .   ? 5.129   -10.223 -12.648 1.000 28.026 0 456 HOH   D O     1 ? 
HETATM 3096 O  O     . HOH   G 6 .   ? 1.551   -24.230 1.874   1.000 49.909 0 457 HOH   D O     1 ? 
HETATM 3097 O  O     . HOH   G 6 .   ? -6.443  -6.544  15.254  1.000 28.635 0 458 HOH   D O     1 ? 
HETATM 3098 O  O     . HOH   G 6 .   ? 8.694   -26.712 5.850   1.000 25.960 0 459 HOH   D O     1 ? 
HETATM 3099 O  O     . HOH   G 6 .   ? 3.156   -24.752 9.271   1.000 32.634 0 460 HOH   D O     1 ? 
HETATM 3100 O  O     . HOH   G 6 .   ? 30.229  -21.023 12.157  1.000 32.181 0 461 HOH   D O     1 ? 
HETATM 3101 O  O     . HOH   G 6 .   ? -8.398  2.506   -2.170  1.000 35.261 0 462 HOH   D O     1 ? 
HETATM 3102 O  O     . HOH   G 6 .   ? 16.374  -31.763 0.256   1.000 45.339 0 463 HOH   D O     1 ? 
HETATM 3103 O  O     . HOH   G 6 .   ? 29.163  -9.574  0.873   1.000 31.563 0 464 HOH   D O     1 ? 
HETATM 3104 O  O     . HOH   G 6 .   ? -0.189  2.631   -12.819 1.000 36.916 0 465 HOH   D O     1 ? 
HETATM 3105 O  O     . HOH   G 6 .   ? 26.875  -9.338  18.580  1.000 44.859 0 466 HOH   D O     1 ? 
HETATM 3106 O  O     . HOH   G 6 .   ? 2.523   -7.425  -12.941 1.000 28.258 0 467 HOH   D O     1 ? 
HETATM 3107 O  O     . HOH   G 6 .   ? 25.915  -8.006  -1.475  1.000 38.258 0 468 HOH   D O     1 ? 
HETATM 3108 O  O     . HOH   G 6 .   ? 15.970  -26.343 14.577  1.000 37.099 0 469 HOH   D O     1 ? 
HETATM 3109 O  O     . HOH   G 6 .   ? 11.538  -35.870 8.059   1.000 45.605 0 470 HOH   D O     1 ? 
HETATM 3110 O  O     . HOH   G 6 .   ? -5.605  7.007   -7.556  1.000 40.214 0 471 HOH   D O     1 ? 
HETATM 3111 O  O     . HOH   G 6 .   ? 1.536   -11.690 -12.701 1.000 29.119 0 472 HOH   D O     1 ? 
HETATM 3112 O  O     . HOH   G 6 .   ? 14.283  -30.590 -1.042  1.000 36.728 0 473 HOH   D O     1 ? 
HETATM 3113 O  O     . HOH   G 6 .   ? 10.305  -29.374 -8.731  1.000 52.640 0 474 HOH   D O     1 ? 
# 
