data_9O2N
# 
_entry.id   9O2N 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9O2N         pdb_00009o2n 10.2210/pdb9o2n/pdb 
WWPDB D_1000294708 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_PDB_obs_spr.id               SPRSDE 
_pdbx_database_PDB_obs_spr.date             2025-04-16 
_pdbx_database_PDB_obs_spr.pdb_id           9O2N 
_pdbx_database_PDB_obs_spr.replace_pdb_id   9NG6 
_pdbx_database_PDB_obs_spr.details          ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9O2N 
_pdbx_database_status.recvd_initial_deposition_date   2025-04-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 geiger@chemistry.msu.edu James Geiger H 'principal investigator/group leader' 0000-0002-9443-4488 
3 draths@chemistry.msu.edu Karen Draths ? 'principal investigator/group leader' 0000-0001-7852-1090 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Silva, K.'    1 ? 
'Geiger, J.H.' 2 ? 
'Draths, K.'   3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'cis-CaaD Y103F mutant soaked with cis-3-chloroacrylic acid' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Silva, K.'    1 ? 
primary 'Geiger, J.H.' 2 ? 
primary 'Draths, K.'   3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Cis-3-chloroacrylic acid dehalogenase' 18551.582 3   ? ? ? ? 
2 water   nat water                                   18.015    116 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;PVYMVYVSQDRLTPSAKHAVAKAITDAHRGLTGTQHFLAQVNFQEQPAGNVFLGGVQQGGDTIFVHGLHREGRSADLKGQ
LAQRIVDDVSVAAEIDRKHIWVFFGEMPAQQMVEYGRFLPQPGHEGEWFDNLSSDERAFMETNVDVSRTENLYFQGLEHH
HHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;PVYMVYVSQDRLTPSAKHAVAKAITDAHRGLTGTQHFLAQVNFQEQPAGNVFLGGVQQGGDTIFVHGLHREGRSADLKGQ
LAQRIVDDVSVAAEIDRKHIWVFFGEMPAQQMVEYGRFLPQPGHEGEWFDNLSSDERAFMETNVDVSRTENLYFQGLEHH
HHHH
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   VAL n 
1 3   TYR n 
1 4   MET n 
1 5   VAL n 
1 6   TYR n 
1 7   VAL n 
1 8   SER n 
1 9   GLN n 
1 10  ASP n 
1 11  ARG n 
1 12  LEU n 
1 13  THR n 
1 14  PRO n 
1 15  SER n 
1 16  ALA n 
1 17  LYS n 
1 18  HIS n 
1 19  ALA n 
1 20  VAL n 
1 21  ALA n 
1 22  LYS n 
1 23  ALA n 
1 24  ILE n 
1 25  THR n 
1 26  ASP n 
1 27  ALA n 
1 28  HIS n 
1 29  ARG n 
1 30  GLY n 
1 31  LEU n 
1 32  THR n 
1 33  GLY n 
1 34  THR n 
1 35  GLN n 
1 36  HIS n 
1 37  PHE n 
1 38  LEU n 
1 39  ALA n 
1 40  GLN n 
1 41  VAL n 
1 42  ASN n 
1 43  PHE n 
1 44  GLN n 
1 45  GLU n 
1 46  GLN n 
1 47  PRO n 
1 48  ALA n 
1 49  GLY n 
1 50  ASN n 
1 51  VAL n 
1 52  PHE n 
1 53  LEU n 
1 54  GLY n 
1 55  GLY n 
1 56  VAL n 
1 57  GLN n 
1 58  GLN n 
1 59  GLY n 
1 60  GLY n 
1 61  ASP n 
1 62  THR n 
1 63  ILE n 
1 64  PHE n 
1 65  VAL n 
1 66  HIS n 
1 67  GLY n 
1 68  LEU n 
1 69  HIS n 
1 70  ARG n 
1 71  GLU n 
1 72  GLY n 
1 73  ARG n 
1 74  SER n 
1 75  ALA n 
1 76  ASP n 
1 77  LEU n 
1 78  LYS n 
1 79  GLY n 
1 80  GLN n 
1 81  LEU n 
1 82  ALA n 
1 83  GLN n 
1 84  ARG n 
1 85  ILE n 
1 86  VAL n 
1 87  ASP n 
1 88  ASP n 
1 89  VAL n 
1 90  SER n 
1 91  VAL n 
1 92  ALA n 
1 93  ALA n 
1 94  GLU n 
1 95  ILE n 
1 96  ASP n 
1 97  ARG n 
1 98  LYS n 
1 99  HIS n 
1 100 ILE n 
1 101 TRP n 
1 102 VAL n 
1 103 PHE n 
1 104 PHE n 
1 105 GLY n 
1 106 GLU n 
1 107 MET n 
1 108 PRO n 
1 109 ALA n 
1 110 GLN n 
1 111 GLN n 
1 112 MET n 
1 113 VAL n 
1 114 GLU n 
1 115 TYR n 
1 116 GLY n 
1 117 ARG n 
1 118 PHE n 
1 119 LEU n 
1 120 PRO n 
1 121 GLN n 
1 122 PRO n 
1 123 GLY n 
1 124 HIS n 
1 125 GLU n 
1 126 GLY n 
1 127 GLU n 
1 128 TRP n 
1 129 PHE n 
1 130 ASP n 
1 131 ASN n 
1 132 LEU n 
1 133 SER n 
1 134 SER n 
1 135 ASP n 
1 136 GLU n 
1 137 ARG n 
1 138 ALA n 
1 139 PHE n 
1 140 MET n 
1 141 GLU n 
1 142 THR n 
1 143 ASN n 
1 144 VAL n 
1 145 ASP n 
1 146 VAL n 
1 147 SER n 
1 148 ARG n 
1 149 THR n 
1 150 GLU n 
1 151 ASN n 
1 152 LEU n 
1 153 TYR n 
1 154 PHE n 
1 155 GLN n 
1 156 GLY n 
1 157 LEU n 
1 158 GLU n 
1 159 HIS n 
1 160 HIS n 
1 161 HIS n 
1 162 HIS n 
1 163 HIS n 
1 164 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   164 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 cis-caaD 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'coryneform bacterium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1728 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   1   1   PRO PRO A . n 
A 1 2   VAL 2   2   2   VAL VAL A . n 
A 1 3   TYR 3   3   3   TYR TYR A . n 
A 1 4   MET 4   4   4   MET MET A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   VAL 7   7   7   VAL VAL A . n 
A 1 8   SER 8   8   8   SER SER A . n 
A 1 9   GLN 9   9   9   GLN GLN A . n 
A 1 10  ASP 10  10  10  ASP ASP A . n 
A 1 11  ARG 11  11  11  ARG ARG A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  THR 13  13  13  THR THR A . n 
A 1 14  PRO 14  14  14  PRO PRO A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  LYS 17  17  17  LYS LYS A . n 
A 1 18  HIS 18  18  18  HIS HIS A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ALA 21  21  21  ALA ALA A . n 
A 1 22  LYS 22  22  22  LYS LYS A . n 
A 1 23  ALA 23  23  23  ALA ALA A . n 
A 1 24  ILE 24  24  24  ILE ILE A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  ALA 27  27  27  ALA ALA A . n 
A 1 28  HIS 28  28  28  HIS HIS A . n 
A 1 29  ARG 29  29  29  ARG ARG A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  THR 32  32  32  THR THR A . n 
A 1 33  GLY 33  33  33  GLY GLY A . n 
A 1 34  THR 34  34  34  THR THR A . n 
A 1 35  GLN 35  35  35  GLN GLN A . n 
A 1 36  HIS 36  36  36  HIS HIS A . n 
A 1 37  PHE 37  37  37  PHE PHE A . n 
A 1 38  LEU 38  38  38  LEU LEU A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  GLN 40  40  40  GLN GLN A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  ASN 42  42  42  ASN ASN A . n 
A 1 43  PHE 43  43  43  PHE PHE A . n 
A 1 44  GLN 44  44  44  GLN GLN A . n 
A 1 45  GLU 45  45  45  GLU GLU A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  ASN 50  50  50  ASN ASN A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  GLY 55  55  55  GLY GLY A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  THR 62  62  62  THR THR A . n 
A 1 63  ILE 63  63  63  ILE ILE A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  HIS 66  66  66  HIS HIS A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  LEU 68  68  68  LEU LEU A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  SER 74  74  74  SER SER A . n 
A 1 75  ALA 75  75  75  ALA ALA A . n 
A 1 76  ASP 76  76  76  ASP ASP A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  GLN 80  80  80  GLN GLN A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ARG 84  84  84  ARG ARG A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  ASP 87  87  87  ASP ASP A . n 
A 1 88  ASP 88  88  88  ASP ASP A . n 
A 1 89  VAL 89  89  89  VAL VAL A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ALA 92  92  92  ALA ALA A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  ILE 95  95  95  ILE ILE A . n 
A 1 96  ASP 96  96  96  ASP ASP A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  HIS 99  99  99  HIS HIS A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 TRP 101 101 101 TRP TRP A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 PHE 104 104 104 PHE PHE A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 GLU 106 106 106 GLU GLU A . n 
A 1 107 MET 107 107 107 MET MET A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 GLN 111 111 111 GLN GLN A . n 
A 1 112 MET 112 112 112 MET MET A . n 
A 1 113 VAL 113 113 113 VAL VAL A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 TYR 115 115 115 TYR TYR A . n 
A 1 116 GLY 116 116 116 GLY GLY A . n 
A 1 117 ARG 117 117 117 ARG ARG A . n 
A 1 118 PHE 118 118 118 PHE PHE A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 PRO 120 120 120 PRO PRO A . n 
A 1 121 GLN 121 121 121 GLN GLN A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 HIS 124 124 124 HIS HIS A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 GLU 127 127 127 GLU GLU A . n 
A 1 128 TRP 128 128 128 TRP TRP A . n 
A 1 129 PHE 129 129 129 PHE PHE A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 ASN 131 131 131 ASN ASN A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 SER 133 133 133 SER SER A . n 
A 1 134 SER 134 134 134 SER SER A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 GLU 136 136 136 GLU GLU A . n 
A 1 137 ARG 137 137 137 ARG ARG A . n 
A 1 138 ALA 138 138 138 ALA ALA A . n 
A 1 139 PHE 139 139 139 PHE PHE A . n 
A 1 140 MET 140 140 140 MET MET A . n 
A 1 141 GLU 141 141 141 GLU GLU A . n 
A 1 142 THR 142 142 142 THR THR A . n 
A 1 143 ASN 143 143 143 ASN ASN A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 VAL 146 146 ?   ?   ?   A . n 
A 1 147 SER 147 147 ?   ?   ?   A . n 
A 1 148 ARG 148 148 ?   ?   ?   A . n 
A 1 149 THR 149 149 ?   ?   ?   A . n 
A 1 150 GLU 150 150 ?   ?   ?   A . n 
A 1 151 ASN 151 151 ?   ?   ?   A . n 
A 1 152 LEU 152 152 ?   ?   ?   A . n 
A 1 153 TYR 153 153 ?   ?   ?   A . n 
A 1 154 PHE 154 154 ?   ?   ?   A . n 
A 1 155 GLN 155 155 ?   ?   ?   A . n 
A 1 156 GLY 156 156 ?   ?   ?   A . n 
A 1 157 LEU 157 157 ?   ?   ?   A . n 
A 1 158 GLU 158 158 ?   ?   ?   A . n 
A 1 159 HIS 159 159 ?   ?   ?   A . n 
A 1 160 HIS 160 160 ?   ?   ?   A . n 
A 1 161 HIS 161 161 ?   ?   ?   A . n 
A 1 162 HIS 162 162 ?   ?   ?   A . n 
A 1 163 HIS 163 163 ?   ?   ?   A . n 
A 1 164 HIS 164 164 ?   ?   ?   A . n 
B 1 1   PRO 1   1   1   PRO PRO B . n 
B 1 2   VAL 2   2   2   VAL VAL B . n 
B 1 3   TYR 3   3   3   TYR TYR B . n 
B 1 4   MET 4   4   4   MET MET B . n 
B 1 5   VAL 5   5   5   VAL VAL B . n 
B 1 6   TYR 6   6   6   TYR TYR B . n 
B 1 7   VAL 7   7   7   VAL VAL B . n 
B 1 8   SER 8   8   8   SER SER B . n 
B 1 9   GLN 9   9   9   GLN GLN B . n 
B 1 10  ASP 10  10  10  ASP ASP B . n 
B 1 11  ARG 11  11  11  ARG ARG B . n 
B 1 12  LEU 12  12  12  LEU LEU B . n 
B 1 13  THR 13  13  13  THR THR B . n 
B 1 14  PRO 14  14  14  PRO PRO B . n 
B 1 15  SER 15  15  15  SER SER B . n 
B 1 16  ALA 16  16  16  ALA ALA B . n 
B 1 17  LYS 17  17  17  LYS LYS B . n 
B 1 18  HIS 18  18  18  HIS HIS B . n 
B 1 19  ALA 19  19  19  ALA ALA B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  ALA 21  21  21  ALA ALA B . n 
B 1 22  LYS 22  22  22  LYS LYS B . n 
B 1 23  ALA 23  23  23  ALA ALA B . n 
B 1 24  ILE 24  24  24  ILE ILE B . n 
B 1 25  THR 25  25  25  THR THR B . n 
B 1 26  ASP 26  26  26  ASP ASP B . n 
B 1 27  ALA 27  27  27  ALA ALA B . n 
B 1 28  HIS 28  28  28  HIS HIS B . n 
B 1 29  ARG 29  29  29  ARG ARG B . n 
B 1 30  GLY 30  30  30  GLY GLY B . n 
B 1 31  LEU 31  31  31  LEU LEU B . n 
B 1 32  THR 32  32  32  THR THR B . n 
B 1 33  GLY 33  33  33  GLY GLY B . n 
B 1 34  THR 34  34  34  THR THR B . n 
B 1 35  GLN 35  35  35  GLN GLN B . n 
B 1 36  HIS 36  36  36  HIS HIS B . n 
B 1 37  PHE 37  37  37  PHE PHE B . n 
B 1 38  LEU 38  38  38  LEU LEU B . n 
B 1 39  ALA 39  39  39  ALA ALA B . n 
B 1 40  GLN 40  40  40  GLN GLN B . n 
B 1 41  VAL 41  41  41  VAL VAL B . n 
B 1 42  ASN 42  42  42  ASN ASN B . n 
B 1 43  PHE 43  43  43  PHE PHE B . n 
B 1 44  GLN 44  44  44  GLN GLN B . n 
B 1 45  GLU 45  45  45  GLU GLU B . n 
B 1 46  GLN 46  46  46  GLN GLN B . n 
B 1 47  PRO 47  47  47  PRO PRO B . n 
B 1 48  ALA 48  48  48  ALA ALA B . n 
B 1 49  GLY 49  49  49  GLY GLY B . n 
B 1 50  ASN 50  50  50  ASN ASN B . n 
B 1 51  VAL 51  51  51  VAL VAL B . n 
B 1 52  PHE 52  52  52  PHE PHE B . n 
B 1 53  LEU 53  53  53  LEU LEU B . n 
B 1 54  GLY 54  54  54  GLY GLY B . n 
B 1 55  GLY 55  55  55  GLY GLY B . n 
B 1 56  VAL 56  56  56  VAL VAL B . n 
B 1 57  GLN 57  57  57  GLN GLN B . n 
B 1 58  GLN 58  58  58  GLN GLN B . n 
B 1 59  GLY 59  59  59  GLY GLY B . n 
B 1 60  GLY 60  60  60  GLY GLY B . n 
B 1 61  ASP 61  61  61  ASP ASP B . n 
B 1 62  THR 62  62  62  THR THR B . n 
B 1 63  ILE 63  63  63  ILE ILE B . n 
B 1 64  PHE 64  64  64  PHE PHE B . n 
B 1 65  VAL 65  65  65  VAL VAL B . n 
B 1 66  HIS 66  66  66  HIS HIS B . n 
B 1 67  GLY 67  67  67  GLY GLY B . n 
B 1 68  LEU 68  68  68  LEU LEU B . n 
B 1 69  HIS 69  69  69  HIS HIS B . n 
B 1 70  ARG 70  70  70  ARG ARG B . n 
B 1 71  GLU 71  71  71  GLU GLU B . n 
B 1 72  GLY 72  72  72  GLY GLY B . n 
B 1 73  ARG 73  73  73  ARG ARG B . n 
B 1 74  SER 74  74  74  SER SER B . n 
B 1 75  ALA 75  75  75  ALA ALA B . n 
B 1 76  ASP 76  76  76  ASP ASP B . n 
B 1 77  LEU 77  77  77  LEU LEU B . n 
B 1 78  LYS 78  78  78  LYS LYS B . n 
B 1 79  GLY 79  79  79  GLY GLY B . n 
B 1 80  GLN 80  80  80  GLN GLN B . n 
B 1 81  LEU 81  81  81  LEU LEU B . n 
B 1 82  ALA 82  82  82  ALA ALA B . n 
B 1 83  GLN 83  83  83  GLN GLN B . n 
B 1 84  ARG 84  84  84  ARG ARG B . n 
B 1 85  ILE 85  85  85  ILE ILE B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  ASP 87  87  87  ASP ASP B . n 
B 1 88  ASP 88  88  88  ASP ASP B . n 
B 1 89  VAL 89  89  89  VAL VAL B . n 
B 1 90  SER 90  90  90  SER SER B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  ALA 92  92  92  ALA ALA B . n 
B 1 93  ALA 93  93  93  ALA ALA B . n 
B 1 94  GLU 94  94  94  GLU GLU B . n 
B 1 95  ILE 95  95  95  ILE ILE B . n 
B 1 96  ASP 96  96  96  ASP ASP B . n 
B 1 97  ARG 97  97  97  ARG ARG B . n 
B 1 98  LYS 98  98  98  LYS LYS B . n 
B 1 99  HIS 99  99  99  HIS HIS B . n 
B 1 100 ILE 100 100 100 ILE ILE B . n 
B 1 101 TRP 101 101 101 TRP TRP B . n 
B 1 102 VAL 102 102 102 VAL VAL B . n 
B 1 103 PHE 103 103 103 PHE PHE B . n 
B 1 104 PHE 104 104 104 PHE PHE B . n 
B 1 105 GLY 105 105 105 GLY GLY B . n 
B 1 106 GLU 106 106 106 GLU GLU B . n 
B 1 107 MET 107 107 107 MET MET B . n 
B 1 108 PRO 108 108 108 PRO PRO B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 GLN 110 110 110 GLN GLN B . n 
B 1 111 GLN 111 111 111 GLN GLN B . n 
B 1 112 MET 112 112 112 MET MET B . n 
B 1 113 VAL 113 113 113 VAL VAL B . n 
B 1 114 GLU 114 114 114 GLU GLU B . n 
B 1 115 TYR 115 115 115 TYR TYR B . n 
B 1 116 GLY 116 116 116 GLY GLY B . n 
B 1 117 ARG 117 117 117 ARG ARG B . n 
B 1 118 PHE 118 118 118 PHE PHE B . n 
B 1 119 LEU 119 119 119 LEU LEU B . n 
B 1 120 PRO 120 120 120 PRO PRO B . n 
B 1 121 GLN 121 121 121 GLN GLN B . n 
B 1 122 PRO 122 122 122 PRO PRO B . n 
B 1 123 GLY 123 123 123 GLY GLY B . n 
B 1 124 HIS 124 124 124 HIS HIS B . n 
B 1 125 GLU 125 125 125 GLU GLU B . n 
B 1 126 GLY 126 126 126 GLY GLY B . n 
B 1 127 GLU 127 127 127 GLU GLU B . n 
B 1 128 TRP 128 128 128 TRP TRP B . n 
B 1 129 PHE 129 129 129 PHE PHE B . n 
B 1 130 ASP 130 130 130 ASP ASP B . n 
B 1 131 ASN 131 131 131 ASN ASN B . n 
B 1 132 LEU 132 132 132 LEU LEU B . n 
B 1 133 SER 133 133 133 SER SER B . n 
B 1 134 SER 134 134 134 SER SER B . n 
B 1 135 ASP 135 135 135 ASP ASP B . n 
B 1 136 GLU 136 136 136 GLU GLU B . n 
B 1 137 ARG 137 137 137 ARG ARG B . n 
B 1 138 ALA 138 138 138 ALA ALA B . n 
B 1 139 PHE 139 139 139 PHE PHE B . n 
B 1 140 MET 140 140 140 MET MET B . n 
B 1 141 GLU 141 141 141 GLU GLU B . n 
B 1 142 THR 142 142 142 THR THR B . n 
B 1 143 ASN 143 143 143 ASN ASN B . n 
B 1 144 VAL 144 144 144 VAL VAL B . n 
B 1 145 ASP 145 145 145 ASP ASP B . n 
B 1 146 VAL 146 146 ?   ?   ?   B . n 
B 1 147 SER 147 147 ?   ?   ?   B . n 
B 1 148 ARG 148 148 ?   ?   ?   B . n 
B 1 149 THR 149 149 ?   ?   ?   B . n 
B 1 150 GLU 150 150 ?   ?   ?   B . n 
B 1 151 ASN 151 151 ?   ?   ?   B . n 
B 1 152 LEU 152 152 ?   ?   ?   B . n 
B 1 153 TYR 153 153 ?   ?   ?   B . n 
B 1 154 PHE 154 154 ?   ?   ?   B . n 
B 1 155 GLN 155 155 ?   ?   ?   B . n 
B 1 156 GLY 156 156 ?   ?   ?   B . n 
B 1 157 LEU 157 157 ?   ?   ?   B . n 
B 1 158 GLU 158 158 ?   ?   ?   B . n 
B 1 159 HIS 159 159 ?   ?   ?   B . n 
B 1 160 HIS 160 160 ?   ?   ?   B . n 
B 1 161 HIS 161 161 ?   ?   ?   B . n 
B 1 162 HIS 162 162 ?   ?   ?   B . n 
B 1 163 HIS 163 163 ?   ?   ?   B . n 
B 1 164 HIS 164 164 ?   ?   ?   B . n 
C 1 1   PRO 1   1   1   PRO PRO C . n 
C 1 2   VAL 2   2   2   VAL VAL C . n 
C 1 3   TYR 3   3   3   TYR TYR C . n 
C 1 4   MET 4   4   4   MET MET C . n 
C 1 5   VAL 5   5   5   VAL VAL C . n 
C 1 6   TYR 6   6   6   TYR TYR C . n 
C 1 7   VAL 7   7   7   VAL VAL C . n 
C 1 8   SER 8   8   8   SER SER C . n 
C 1 9   GLN 9   9   9   GLN GLN C . n 
C 1 10  ASP 10  10  10  ASP ASP C . n 
C 1 11  ARG 11  11  11  ARG ARG C . n 
C 1 12  LEU 12  12  12  LEU LEU C . n 
C 1 13  THR 13  13  13  THR THR C . n 
C 1 14  PRO 14  14  14  PRO PRO C . n 
C 1 15  SER 15  15  15  SER SER C . n 
C 1 16  ALA 16  16  16  ALA ALA C . n 
C 1 17  LYS 17  17  17  LYS LYS C . n 
C 1 18  HIS 18  18  18  HIS HIS C . n 
C 1 19  ALA 19  19  19  ALA ALA C . n 
C 1 20  VAL 20  20  20  VAL VAL C . n 
C 1 21  ALA 21  21  21  ALA ALA C . n 
C 1 22  LYS 22  22  22  LYS LYS C . n 
C 1 23  ALA 23  23  23  ALA ALA C . n 
C 1 24  ILE 24  24  24  ILE ILE C . n 
C 1 25  THR 25  25  25  THR THR C . n 
C 1 26  ASP 26  26  26  ASP ASP C . n 
C 1 27  ALA 27  27  27  ALA ALA C . n 
C 1 28  HIS 28  28  28  HIS HIS C . n 
C 1 29  ARG 29  29  29  ARG ARG C . n 
C 1 30  GLY 30  30  30  GLY GLY C . n 
C 1 31  LEU 31  31  31  LEU LEU C . n 
C 1 32  THR 32  32  32  THR THR C . n 
C 1 33  GLY 33  33  33  GLY GLY C . n 
C 1 34  THR 34  34  34  THR THR C . n 
C 1 35  GLN 35  35  35  GLN GLN C . n 
C 1 36  HIS 36  36  36  HIS HIS C . n 
C 1 37  PHE 37  37  37  PHE PHE C . n 
C 1 38  LEU 38  38  38  LEU LEU C . n 
C 1 39  ALA 39  39  39  ALA ALA C . n 
C 1 40  GLN 40  40  40  GLN GLN C . n 
C 1 41  VAL 41  41  41  VAL VAL C . n 
C 1 42  ASN 42  42  42  ASN ASN C . n 
C 1 43  PHE 43  43  43  PHE PHE C . n 
C 1 44  GLN 44  44  44  GLN GLN C . n 
C 1 45  GLU 45  45  45  GLU GLU C . n 
C 1 46  GLN 46  46  46  GLN GLN C . n 
C 1 47  PRO 47  47  47  PRO PRO C . n 
C 1 48  ALA 48  48  48  ALA ALA C . n 
C 1 49  GLY 49  49  49  GLY GLY C . n 
C 1 50  ASN 50  50  50  ASN ASN C . n 
C 1 51  VAL 51  51  51  VAL VAL C . n 
C 1 52  PHE 52  52  52  PHE PHE C . n 
C 1 53  LEU 53  53  53  LEU LEU C . n 
C 1 54  GLY 54  54  54  GLY GLY C . n 
C 1 55  GLY 55  55  55  GLY GLY C . n 
C 1 56  VAL 56  56  56  VAL VAL C . n 
C 1 57  GLN 57  57  57  GLN GLN C . n 
C 1 58  GLN 58  58  58  GLN GLN C . n 
C 1 59  GLY 59  59  59  GLY GLY C . n 
C 1 60  GLY 60  60  60  GLY GLY C . n 
C 1 61  ASP 61  61  61  ASP ASP C . n 
C 1 62  THR 62  62  62  THR THR C . n 
C 1 63  ILE 63  63  63  ILE ILE C . n 
C 1 64  PHE 64  64  64  PHE PHE C . n 
C 1 65  VAL 65  65  65  VAL VAL C . n 
C 1 66  HIS 66  66  66  HIS HIS C . n 
C 1 67  GLY 67  67  67  GLY GLY C . n 
C 1 68  LEU 68  68  68  LEU LEU C . n 
C 1 69  HIS 69  69  69  HIS HIS C . n 
C 1 70  ARG 70  70  70  ARG ARG C . n 
C 1 71  GLU 71  71  71  GLU GLU C . n 
C 1 72  GLY 72  72  72  GLY GLY C . n 
C 1 73  ARG 73  73  73  ARG ARG C . n 
C 1 74  SER 74  74  74  SER SER C . n 
C 1 75  ALA 75  75  75  ALA ALA C . n 
C 1 76  ASP 76  76  76  ASP ASP C . n 
C 1 77  LEU 77  77  77  LEU LEU C . n 
C 1 78  LYS 78  78  78  LYS LYS C . n 
C 1 79  GLY 79  79  79  GLY GLY C . n 
C 1 80  GLN 80  80  80  GLN GLN C . n 
C 1 81  LEU 81  81  81  LEU LEU C . n 
C 1 82  ALA 82  82  82  ALA ALA C . n 
C 1 83  GLN 83  83  83  GLN GLN C . n 
C 1 84  ARG 84  84  84  ARG ARG C . n 
C 1 85  ILE 85  85  85  ILE ILE C . n 
C 1 86  VAL 86  86  86  VAL VAL C . n 
C 1 87  ASP 87  87  87  ASP ASP C . n 
C 1 88  ASP 88  88  88  ASP ASP C . n 
C 1 89  VAL 89  89  89  VAL VAL C . n 
C 1 90  SER 90  90  90  SER SER C . n 
C 1 91  VAL 91  91  91  VAL VAL C . n 
C 1 92  ALA 92  92  92  ALA ALA C . n 
C 1 93  ALA 93  93  93  ALA ALA C . n 
C 1 94  GLU 94  94  94  GLU GLU C . n 
C 1 95  ILE 95  95  95  ILE ILE C . n 
C 1 96  ASP 96  96  96  ASP ASP C . n 
C 1 97  ARG 97  97  97  ARG ARG C . n 
C 1 98  LYS 98  98  98  LYS LYS C . n 
C 1 99  HIS 99  99  99  HIS HIS C . n 
C 1 100 ILE 100 100 100 ILE ILE C . n 
C 1 101 TRP 101 101 101 TRP TRP C . n 
C 1 102 VAL 102 102 102 VAL VAL C . n 
C 1 103 PHE 103 103 103 PHE PHE C . n 
C 1 104 PHE 104 104 104 PHE PHE C . n 
C 1 105 GLY 105 105 105 GLY GLY C . n 
C 1 106 GLU 106 106 106 GLU GLU C . n 
C 1 107 MET 107 107 107 MET MET C . n 
C 1 108 PRO 108 108 108 PRO PRO C . n 
C 1 109 ALA 109 109 109 ALA ALA C . n 
C 1 110 GLN 110 110 110 GLN GLN C . n 
C 1 111 GLN 111 111 111 GLN GLN C . n 
C 1 112 MET 112 112 112 MET MET C . n 
C 1 113 VAL 113 113 113 VAL VAL C . n 
C 1 114 GLU 114 114 114 GLU GLU C . n 
C 1 115 TYR 115 115 115 TYR TYR C . n 
C 1 116 GLY 116 116 116 GLY GLY C . n 
C 1 117 ARG 117 117 117 ARG ARG C . n 
C 1 118 PHE 118 118 118 PHE PHE C . n 
C 1 119 LEU 119 119 119 LEU LEU C . n 
C 1 120 PRO 120 120 120 PRO PRO C . n 
C 1 121 GLN 121 121 121 GLN GLN C . n 
C 1 122 PRO 122 122 122 PRO PRO C . n 
C 1 123 GLY 123 123 123 GLY GLY C . n 
C 1 124 HIS 124 124 124 HIS HIS C . n 
C 1 125 GLU 125 125 125 GLU GLU C . n 
C 1 126 GLY 126 126 126 GLY GLY C . n 
C 1 127 GLU 127 127 127 GLU GLU C . n 
C 1 128 TRP 128 128 128 TRP TRP C . n 
C 1 129 PHE 129 129 129 PHE PHE C . n 
C 1 130 ASP 130 130 130 ASP ASP C . n 
C 1 131 ASN 131 131 131 ASN ASN C . n 
C 1 132 LEU 132 132 132 LEU LEU C . n 
C 1 133 SER 133 133 133 SER SER C . n 
C 1 134 SER 134 134 134 SER SER C . n 
C 1 135 ASP 135 135 135 ASP ASP C . n 
C 1 136 GLU 136 136 136 GLU GLU C . n 
C 1 137 ARG 137 137 137 ARG ARG C . n 
C 1 138 ALA 138 138 138 ALA ALA C . n 
C 1 139 PHE 139 139 139 PHE PHE C . n 
C 1 140 MET 140 140 140 MET MET C . n 
C 1 141 GLU 141 141 141 GLU GLU C . n 
C 1 142 THR 142 142 142 THR THR C . n 
C 1 143 ASN 143 143 143 ASN ASN C . n 
C 1 144 VAL 144 144 144 VAL VAL C . n 
C 1 145 ASP 145 145 145 ASP ASP C . n 
C 1 146 VAL 146 146 ?   ?   ?   C . n 
C 1 147 SER 147 147 ?   ?   ?   C . n 
C 1 148 ARG 148 148 ?   ?   ?   C . n 
C 1 149 THR 149 149 ?   ?   ?   C . n 
C 1 150 GLU 150 150 ?   ?   ?   C . n 
C 1 151 ASN 151 151 ?   ?   ?   C . n 
C 1 152 LEU 152 152 ?   ?   ?   C . n 
C 1 153 TYR 153 153 ?   ?   ?   C . n 
C 1 154 PHE 154 154 ?   ?   ?   C . n 
C 1 155 GLN 155 155 ?   ?   ?   C . n 
C 1 156 GLY 156 156 ?   ?   ?   C . n 
C 1 157 LEU 157 157 ?   ?   ?   C . n 
C 1 158 GLU 158 158 ?   ?   ?   C . n 
C 1 159 HIS 159 159 ?   ?   ?   C . n 
C 1 160 HIS 160 160 ?   ?   ?   C . n 
C 1 161 HIS 161 161 ?   ?   ?   C . n 
C 1 162 HIS 162 162 ?   ?   ?   C . n 
C 1 163 HIS 163 163 ?   ?   ?   C . n 
C 1 164 HIS 164 164 ?   ?   ?   C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 HOH 1  201 98  HOH HOH A . 
D 2 HOH 2  202 38  HOH HOH A . 
D 2 HOH 3  203 66  HOH HOH A . 
D 2 HOH 4  204 57  HOH HOH A . 
D 2 HOH 5  205 13  HOH HOH A . 
D 2 HOH 6  206 88  HOH HOH A . 
D 2 HOH 7  207 120 HOH HOH A . 
D 2 HOH 8  208 33  HOH HOH A . 
D 2 HOH 9  209 5   HOH HOH A . 
D 2 HOH 10 210 1   HOH HOH A . 
D 2 HOH 11 211 35  HOH HOH A . 
D 2 HOH 12 212 46  HOH HOH A . 
D 2 HOH 13 213 36  HOH HOH A . 
D 2 HOH 14 214 119 HOH HOH A . 
D 2 HOH 15 215 59  HOH HOH A . 
D 2 HOH 16 216 61  HOH HOH A . 
D 2 HOH 17 217 48  HOH HOH A . 
D 2 HOH 18 218 11  HOH HOH A . 
D 2 HOH 19 219 108 HOH HOH A . 
D 2 HOH 20 220 7   HOH HOH A . 
D 2 HOH 21 221 52  HOH HOH A . 
D 2 HOH 22 222 55  HOH HOH A . 
D 2 HOH 23 223 56  HOH HOH A . 
D 2 HOH 24 224 81  HOH HOH A . 
D 2 HOH 25 225 73  HOH HOH A . 
D 2 HOH 26 226 77  HOH HOH A . 
D 2 HOH 27 227 15  HOH HOH A . 
D 2 HOH 28 228 44  HOH HOH A . 
D 2 HOH 29 229 83  HOH HOH A . 
D 2 HOH 30 230 85  HOH HOH A . 
D 2 HOH 31 231 97  HOH HOH A . 
D 2 HOH 32 232 67  HOH HOH A . 
D 2 HOH 33 233 70  HOH HOH A . 
D 2 HOH 34 234 106 HOH HOH A . 
D 2 HOH 35 235 50  HOH HOH A . 
D 2 HOH 36 236 96  HOH HOH A . 
D 2 HOH 37 237 60  HOH HOH A . 
D 2 HOH 38 238 82  HOH HOH A . 
D 2 HOH 39 239 104 HOH HOH A . 
E 2 HOH 1  201 64  HOH HOH B . 
E 2 HOH 2  202 99  HOH HOH B . 
E 2 HOH 3  203 72  HOH HOH B . 
E 2 HOH 4  204 63  HOH HOH B . 
E 2 HOH 5  205 121 HOH HOH B . 
E 2 HOH 6  206 95  HOH HOH B . 
E 2 HOH 7  207 100 HOH HOH B . 
E 2 HOH 8  208 4   HOH HOH B . 
E 2 HOH 9  209 29  HOH HOH B . 
E 2 HOH 10 210 31  HOH HOH B . 
E 2 HOH 11 211 6   HOH HOH B . 
E 2 HOH 12 212 18  HOH HOH B . 
E 2 HOH 13 213 3   HOH HOH B . 
E 2 HOH 14 214 37  HOH HOH B . 
E 2 HOH 15 215 116 HOH HOH B . 
E 2 HOH 16 216 17  HOH HOH B . 
E 2 HOH 17 217 69  HOH HOH B . 
E 2 HOH 18 218 23  HOH HOH B . 
E 2 HOH 19 219 87  HOH HOH B . 
E 2 HOH 20 220 26  HOH HOH B . 
E 2 HOH 21 221 32  HOH HOH B . 
E 2 HOH 22 222 49  HOH HOH B . 
E 2 HOH 23 223 22  HOH HOH B . 
E 2 HOH 24 224 74  HOH HOH B . 
E 2 HOH 25 225 94  HOH HOH B . 
E 2 HOH 26 226 28  HOH HOH B . 
E 2 HOH 27 227 12  HOH HOH B . 
E 2 HOH 28 228 93  HOH HOH B . 
E 2 HOH 29 229 58  HOH HOH B . 
E 2 HOH 30 230 2   HOH HOH B . 
E 2 HOH 31 231 117 HOH HOH B . 
E 2 HOH 32 232 107 HOH HOH B . 
E 2 HOH 33 233 54  HOH HOH B . 
E 2 HOH 34 234 80  HOH HOH B . 
E 2 HOH 35 235 47  HOH HOH B . 
E 2 HOH 36 236 102 HOH HOH B . 
E 2 HOH 37 237 90  HOH HOH B . 
E 2 HOH 38 238 51  HOH HOH B . 
E 2 HOH 39 239 53  HOH HOH B . 
E 2 HOH 40 240 105 HOH HOH B . 
F 2 HOH 1  201 84  HOH HOH C . 
F 2 HOH 2  202 71  HOH HOH C . 
F 2 HOH 3  203 8   HOH HOH C . 
F 2 HOH 4  204 20  HOH HOH C . 
F 2 HOH 5  205 114 HOH HOH C . 
F 2 HOH 6  206 68  HOH HOH C . 
F 2 HOH 7  207 19  HOH HOH C . 
F 2 HOH 8  208 34  HOH HOH C . 
F 2 HOH 9  209 89  HOH HOH C . 
F 2 HOH 10 210 14  HOH HOH C . 
F 2 HOH 11 211 9   HOH HOH C . 
F 2 HOH 12 212 40  HOH HOH C . 
F 2 HOH 13 213 91  HOH HOH C . 
F 2 HOH 14 214 45  HOH HOH C . 
F 2 HOH 15 215 62  HOH HOH C . 
F 2 HOH 16 216 92  HOH HOH C . 
F 2 HOH 17 217 113 HOH HOH C . 
F 2 HOH 18 218 25  HOH HOH C . 
F 2 HOH 19 219 10  HOH HOH C . 
F 2 HOH 20 220 65  HOH HOH C . 
F 2 HOH 21 221 24  HOH HOH C . 
F 2 HOH 22 222 39  HOH HOH C . 
F 2 HOH 23 223 21  HOH HOH C . 
F 2 HOH 24 224 43  HOH HOH C . 
F 2 HOH 25 225 103 HOH HOH C . 
F 2 HOH 26 226 79  HOH HOH C . 
F 2 HOH 27 227 16  HOH HOH C . 
F 2 HOH 28 228 86  HOH HOH C . 
F 2 HOH 29 229 41  HOH HOH C . 
F 2 HOH 30 230 27  HOH HOH C . 
F 2 HOH 31 231 42  HOH HOH C . 
F 2 HOH 32 232 101 HOH HOH C . 
F 2 HOH 33 233 30  HOH HOH C . 
F 2 HOH 34 234 75  HOH HOH C . 
F 2 HOH 35 235 76  HOH HOH C . 
F 2 HOH 36 236 115 HOH HOH C . 
F 2 HOH 37 237 78  HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.2_5419 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           ? 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9O2N 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     60.641 
_cell.length_a_esd                 ? 
_cell.length_b                     100.527 
_cell.length_b_esd                 ? 
_cell.length_c                     147.025 
_cell.length_c_esd                 ? 
_cell.volume                       896272.899 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9O2N 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9O2N 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.00 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.47 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M sodium fluoride 20% w/v PEG 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            296 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-06-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.13 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 21-ID-D' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.13 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   21-ID-D 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          28.73 
_reflns.entry_id                                       9O2N 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20691 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           88.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.18 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.040 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.20 
_reflns_shell.d_res_low                                     2.24 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1026 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.222 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.32 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9O2N 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             30.00 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20511 
_refine.ls_number_reflns_R_free                  3337 
_refine.ls_number_reflns_R_work                  30872 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    77.10 
_refine.ls_percent_reflns_R_free                 9.75 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1983 
_refine.ls_R_factor_R_free                       0.2371 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1940 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.4104 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2389 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        30.00 
_refine_hist.number_atoms_solvent             116 
_refine_hist.number_atoms_total               3539 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3423 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0084  ? 3507 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 0.9578  ? 4746 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 0.0581  ? 495  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.0089  ? 639  ? f_plane_restr      ? ? ? 
'X-RAY DIFFRACTION' ? 18.0764 ? 1260 ? f_dihedral_angle_d ? ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.23  . . 76  803  46.91 . . . . 0.2083 . . . . . . . . . . . . . . . 0.2228 
'X-RAY DIFFRACTION' 2.23 2.26  . . 134 911  55.70 . . . . 0.1981 . . . . . . . . . . . . . . . 0.2457 
'X-RAY DIFFRACTION' 2.26 2.30  . . 75  817  49.47 . . . . 0.2299 . . . . . . . . . . . . . . . 0.2497 
'X-RAY DIFFRACTION' 2.30 2.33  . . 79  697  41.39 . . . . 0.2336 . . . . . . . . . . . . . . . 0.3379 
'X-RAY DIFFRACTION' 2.33 2.37  . . 122 1054 64.94 . . . . 0.2144 . . . . . . . . . . . . . . . 0.3145 
'X-RAY DIFFRACTION' 2.37 2.42  . . 112 1184 69.94 . . . . 0.2133 . . . . . . . . . . . . . . . 0.2632 
'X-RAY DIFFRACTION' 2.42 2.46  . . 145 1274 77.08 . . . . 0.2165 . . . . . . . . . . . . . . . 0.2709 
'X-RAY DIFFRACTION' 2.46 2.51  . . 143 1355 80.71 . . . . 0.2226 . . . . . . . . . . . . . . . 0.2742 
'X-RAY DIFFRACTION' 2.51 2.57  . . 132 1408 83.06 . . . . 0.1967 . . . . . . . . . . . . . . . 0.2667 
'X-RAY DIFFRACTION' 2.57 2.63  . . 143 1373 83.07 . . . . 0.2049 . . . . . . . . . . . . . . . 0.2944 
'X-RAY DIFFRACTION' 2.63 2.69  . . 150 1381 82.14 . . . . 0.2179 . . . . . . . . . . . . . . . 0.2826 
'X-RAY DIFFRACTION' 2.69 2.77  . . 158 1386 82.88 . . . . 0.1996 . . . . . . . . . . . . . . . 0.2320 
'X-RAY DIFFRACTION' 2.77 2.85  . . 143 1369 83.44 . . . . 0.2085 . . . . . . . . . . . . . . . 0.2753 
'X-RAY DIFFRACTION' 2.85 2.94  . . 156 1370 81.17 . . . . 0.1922 . . . . . . . . . . . . . . . 0.2740 
'X-RAY DIFFRACTION' 2.94 3.04  . . 143 1354 81.31 . . . . 0.2015 . . . . . . . . . . . . . . . 0.2488 
'X-RAY DIFFRACTION' 3.04 3.17  . . 172 1372 84.46 . . . . 0.1995 . . . . . . . . . . . . . . . 0.2597 
'X-RAY DIFFRACTION' 3.17 3.31  . . 138 1408 84.20 . . . . 0.1931 . . . . . . . . . . . . . . . 0.2801 
'X-RAY DIFFRACTION' 3.31 3.48  . . 154 1408 83.53 . . . . 0.1895 . . . . . . . . . . . . . . . 0.2319 
'X-RAY DIFFRACTION' 3.48 3.70  . . 156 1340 80.69 . . . . 0.1802 . . . . . . . . . . . . . . . 0.2285 
'X-RAY DIFFRACTION' 3.70 3.99  . . 146 1480 88.61 . . . . 0.1881 . . . . . . . . . . . . . . . 0.2389 
'X-RAY DIFFRACTION' 3.99 4.39  . . 158 1569 93.10 . . . . 0.1646 . . . . . . . . . . . . . . . 0.1801 
'X-RAY DIFFRACTION' 4.39 5.02  . . 167 1533 92.29 . . . . 0.1754 . . . . . . . . . . . . . . . 0.2010 
'X-RAY DIFFRACTION' 5.02 6.31  . . 166 1557 92.98 . . . . 0.2048 . . . . . . . . . . . . . . . 0.2349 
'X-RAY DIFFRACTION' 6.32 30.00 . . 169 1469 88.25 . . . . 0.2040 . . . . . . . . . . . . . . . 0.1963 
# 
_struct.entry_id                     9O2N 
_struct.title                        'cis-CaaD Y103F mutant soaked with cis-3-chloroacrylic acid' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9O2N 
_struct_keywords.text            'Tautomerase, cis-CaaD, cis-3-chloroacrylic acid, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q6VPE5_9CORY 
_struct_ref.pdbx_db_accession          Q6VPE5 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;PVYMVYVSQDRLTPSAKHAVAKAITDAHRGLTGTQHFLAQVNFQEQPAGNVFLGGVQQGGDTIFVHGLHREGRSADLKGQ
LAQRIVDDVSVAAEIDRKHIWVYFGEMPAQQMVEYGRFLPQPGHEGEWFDNLSSDERAFMETNVDVSRT
;
_struct_ref.pdbx_align_begin           2 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9O2N A 1 ? 149 ? Q6VPE5 2 ? 150 ? 1 149 
2 1 9O2N B 1 ? 149 ? Q6VPE5 2 ? 150 ? 1 149 
3 1 9O2N C 1 ? 149 ? Q6VPE5 2 ? 150 ? 1 149 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9O2N PHE A 103 ? UNP Q6VPE5 TYR 104 conflict         103 1  
1 9O2N GLU A 150 ? UNP Q6VPE5 ?   ?   'expression tag' 150 2  
1 9O2N ASN A 151 ? UNP Q6VPE5 ?   ?   'expression tag' 151 3  
1 9O2N LEU A 152 ? UNP Q6VPE5 ?   ?   'expression tag' 152 4  
1 9O2N TYR A 153 ? UNP Q6VPE5 ?   ?   'expression tag' 153 5  
1 9O2N PHE A 154 ? UNP Q6VPE5 ?   ?   'expression tag' 154 6  
1 9O2N GLN A 155 ? UNP Q6VPE5 ?   ?   'expression tag' 155 7  
1 9O2N GLY A 156 ? UNP Q6VPE5 ?   ?   'expression tag' 156 8  
1 9O2N LEU A 157 ? UNP Q6VPE5 ?   ?   'expression tag' 157 9  
1 9O2N GLU A 158 ? UNP Q6VPE5 ?   ?   'expression tag' 158 10 
1 9O2N HIS A 159 ? UNP Q6VPE5 ?   ?   'expression tag' 159 11 
1 9O2N HIS A 160 ? UNP Q6VPE5 ?   ?   'expression tag' 160 12 
1 9O2N HIS A 161 ? UNP Q6VPE5 ?   ?   'expression tag' 161 13 
1 9O2N HIS A 162 ? UNP Q6VPE5 ?   ?   'expression tag' 162 14 
1 9O2N HIS A 163 ? UNP Q6VPE5 ?   ?   'expression tag' 163 15 
1 9O2N HIS A 164 ? UNP Q6VPE5 ?   ?   'expression tag' 164 16 
2 9O2N PHE B 103 ? UNP Q6VPE5 TYR 104 conflict         103 17 
2 9O2N GLU B 150 ? UNP Q6VPE5 ?   ?   'expression tag' 150 18 
2 9O2N ASN B 151 ? UNP Q6VPE5 ?   ?   'expression tag' 151 19 
2 9O2N LEU B 152 ? UNP Q6VPE5 ?   ?   'expression tag' 152 20 
2 9O2N TYR B 153 ? UNP Q6VPE5 ?   ?   'expression tag' 153 21 
2 9O2N PHE B 154 ? UNP Q6VPE5 ?   ?   'expression tag' 154 22 
2 9O2N GLN B 155 ? UNP Q6VPE5 ?   ?   'expression tag' 155 23 
2 9O2N GLY B 156 ? UNP Q6VPE5 ?   ?   'expression tag' 156 24 
2 9O2N LEU B 157 ? UNP Q6VPE5 ?   ?   'expression tag' 157 25 
2 9O2N GLU B 158 ? UNP Q6VPE5 ?   ?   'expression tag' 158 26 
2 9O2N HIS B 159 ? UNP Q6VPE5 ?   ?   'expression tag' 159 27 
2 9O2N HIS B 160 ? UNP Q6VPE5 ?   ?   'expression tag' 160 28 
2 9O2N HIS B 161 ? UNP Q6VPE5 ?   ?   'expression tag' 161 29 
2 9O2N HIS B 162 ? UNP Q6VPE5 ?   ?   'expression tag' 162 30 
2 9O2N HIS B 163 ? UNP Q6VPE5 ?   ?   'expression tag' 163 31 
2 9O2N HIS B 164 ? UNP Q6VPE5 ?   ?   'expression tag' 164 32 
3 9O2N PHE C 103 ? UNP Q6VPE5 TYR 104 conflict         103 33 
3 9O2N GLU C 150 ? UNP Q6VPE5 ?   ?   'expression tag' 150 34 
3 9O2N ASN C 151 ? UNP Q6VPE5 ?   ?   'expression tag' 151 35 
3 9O2N LEU C 152 ? UNP Q6VPE5 ?   ?   'expression tag' 152 36 
3 9O2N TYR C 153 ? UNP Q6VPE5 ?   ?   'expression tag' 153 37 
3 9O2N PHE C 154 ? UNP Q6VPE5 ?   ?   'expression tag' 154 38 
3 9O2N GLN C 155 ? UNP Q6VPE5 ?   ?   'expression tag' 155 39 
3 9O2N GLY C 156 ? UNP Q6VPE5 ?   ?   'expression tag' 156 40 
3 9O2N LEU C 157 ? UNP Q6VPE5 ?   ?   'expression tag' 157 41 
3 9O2N GLU C 158 ? UNP Q6VPE5 ?   ?   'expression tag' 158 42 
3 9O2N HIS C 159 ? UNP Q6VPE5 ?   ?   'expression tag' 159 43 
3 9O2N HIS C 160 ? UNP Q6VPE5 ?   ?   'expression tag' 160 44 
3 9O2N HIS C 161 ? UNP Q6VPE5 ?   ?   'expression tag' 161 45 
3 9O2N HIS C 162 ? UNP Q6VPE5 ?   ?   'expression tag' 162 46 
3 9O2N HIS C 163 ? UNP Q6VPE5 ?   ?   'expression tag' 163 47 
3 9O2N HIS C 164 ? UNP Q6VPE5 ?   ?   'expression tag' 164 48 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 8580  ? 
1 MORE         -45   ? 
1 'SSA (A^2)'  15190 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 13  ? GLY A 33  ? THR A 13  GLY A 33  1 ? 21 
HELX_P HELX_P2  AA2 GLN A 35  ? LEU A 38  ? GLN A 35  LEU A 38  5 ? 4  
HELX_P HELX_P3  AA3 SER A 74  ? GLU A 94  ? SER A 74  GLU A 94  1 ? 21 
HELX_P HELX_P4  AA4 ASP A 96  ? LYS A 98  ? ASP A 96  LYS A 98  5 ? 3  
HELX_P HELX_P5  AA5 PRO A 108 ? GLN A 110 ? PRO A 108 GLN A 110 5 ? 3  
HELX_P HELX_P6  AA6 HIS A 124 ? ASN A 131 ? HIS A 124 ASN A 131 1 ? 8  
HELX_P HELX_P7  AA7 SER A 133 ? THR A 142 ? SER A 133 THR A 142 1 ? 10 
HELX_P HELX_P8  AA8 THR B 13  ? GLY B 33  ? THR B 13  GLY B 33  1 ? 21 
HELX_P HELX_P9  AA9 GLN B 35  ? LEU B 38  ? GLN B 35  LEU B 38  5 ? 4  
HELX_P HELX_P10 AB1 SER B 74  ? GLU B 94  ? SER B 74  GLU B 94  1 ? 21 
HELX_P HELX_P11 AB2 ASP B 96  ? LYS B 98  ? ASP B 96  LYS B 98  5 ? 3  
HELX_P HELX_P12 AB3 PRO B 108 ? GLN B 110 ? PRO B 108 GLN B 110 5 ? 3  
HELX_P HELX_P13 AB4 HIS B 124 ? ASP B 130 ? HIS B 124 ASP B 130 1 ? 7  
HELX_P HELX_P14 AB5 SER B 133 ? THR B 142 ? SER B 133 THR B 142 1 ? 10 
HELX_P HELX_P15 AB6 THR C 13  ? GLY C 33  ? THR C 13  GLY C 33  1 ? 21 
HELX_P HELX_P16 AB7 GLN C 35  ? LEU C 38  ? GLN C 35  LEU C 38  5 ? 4  
HELX_P HELX_P17 AB8 SER C 74  ? GLU C 94  ? SER C 74  GLU C 94  1 ? 21 
HELX_P HELX_P18 AB9 ASP C 96  ? LYS C 98  ? ASP C 96  LYS C 98  5 ? 3  
HELX_P HELX_P19 AC1 PRO C 108 ? GLN C 110 ? PRO C 108 GLN C 110 5 ? 3  
HELX_P HELX_P20 AC2 HIS C 124 ? ASN C 131 ? HIS C 124 ASN C 131 1 ? 8  
HELX_P HELX_P21 AC3 SER C 133 ? THR C 142 ? SER C 133 THR C 142 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 8 ? 
AA3 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA1 5 6 ? parallel      
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA2 4 5 ? anti-parallel 
AA2 5 6 ? parallel      
AA2 6 7 ? anti-parallel 
AA2 7 8 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? anti-parallel 
AA3 5 6 ? parallel      
AA3 6 7 ? anti-parallel 
AA3 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL B 56  ? GLN B 57  ? VAL B 56  GLN B 57  
AA1 2 VAL B 51  ? LEU B 53  ? VAL B 51  LEU B 53  
AA1 3 GLN A 40  ? GLN A 46  ? GLN A 40  GLN A 46  
AA1 4 VAL A 2   ? SER A 8   ? VAL A 2   SER A 8   
AA1 5 ILE A 63  ? ARG A 70  ? ILE A 63  ARG A 70  
AA1 6 ILE A 100 ? MET A 107 ? ILE A 100 MET A 107 
AA1 7 MET C 112 ? GLU C 114 ? MET C 112 GLU C 114 
AA1 8 ARG C 117 ? PHE C 118 ? ARG C 117 PHE C 118 
AA2 1 VAL A 56  ? GLN A 57  ? VAL A 56  GLN A 57  
AA2 2 VAL A 51  ? LEU A 53  ? VAL A 51  LEU A 53  
AA2 3 GLN C 40  ? GLN C 46  ? GLN C 40  GLN C 46  
AA2 4 VAL C 2   ? SER C 8   ? VAL C 2   SER C 8   
AA2 5 ILE C 63  ? ARG C 70  ? ILE C 63  ARG C 70  
AA2 6 ILE C 100 ? MET C 107 ? ILE C 100 MET C 107 
AA2 7 MET B 112 ? GLU B 114 ? MET B 112 GLU B 114 
AA2 8 ARG B 117 ? PHE B 118 ? ARG B 117 PHE B 118 
AA3 1 ARG A 117 ? PHE A 118 ? ARG A 117 PHE A 118 
AA3 2 MET A 112 ? GLU A 114 ? MET A 112 GLU A 114 
AA3 3 ILE B 100 ? MET B 107 ? ILE B 100 MET B 107 
AA3 4 ILE B 63  ? ARG B 70  ? ILE B 63  ARG B 70  
AA3 5 VAL B 2   ? SER B 8   ? VAL B 2   SER B 8   
AA3 6 GLN B 40  ? GLN B 46  ? GLN B 40  GLN B 46  
AA3 7 VAL C 51  ? LEU C 53  ? VAL C 51  LEU C 53  
AA3 8 VAL C 56  ? GLN C 57  ? VAL C 56  GLN C 57  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL B 56  ? O VAL B 56  N LEU B 53  ? N LEU B 53  
AA1 2 3 O PHE B 52  ? O PHE B 52  N VAL A 41  ? N VAL A 41  
AA1 3 4 O GLN A 40  ? O GLN A 40  N TYR A 3   ? N TYR A 3   
AA1 4 5 N TYR A 6   ? N TYR A 6   O PHE A 64  ? O PHE A 64  
AA1 5 6 N VAL A 65  ? N VAL A 65  O TRP A 101 ? O TRP A 101 
AA1 6 7 N VAL A 102 ? N VAL A 102 O VAL C 113 ? O VAL C 113 
AA1 7 8 N GLU C 114 ? N GLU C 114 O ARG C 117 ? O ARG C 117 
AA2 1 2 O VAL A 56  ? O VAL A 56  N LEU A 53  ? N LEU A 53  
AA2 2 3 N PHE A 52  ? N PHE A 52  O VAL C 41  ? O VAL C 41  
AA2 3 4 O GLN C 44  ? O GLN C 44  N VAL C 5   ? N VAL C 5   
AA2 4 5 N VAL C 2   ? N VAL C 2   O LEU C 68  ? O LEU C 68  
AA2 5 6 N VAL C 65  ? N VAL C 65  O TRP C 101 ? O TRP C 101 
AA2 6 7 O VAL C 102 ? O VAL C 102 N VAL B 113 ? N VAL B 113 
AA2 7 8 N GLU B 114 ? N GLU B 114 O ARG B 117 ? O ARG B 117 
AA3 1 2 O ARG A 117 ? O ARG A 117 N GLU A 114 ? N GLU A 114 
AA3 2 3 N VAL A 113 ? N VAL A 113 O VAL B 102 ? O VAL B 102 
AA3 3 4 O GLY B 105 ? O GLY B 105 N HIS B 69  ? N HIS B 69  
AA3 4 5 O HIS B 66  ? O HIS B 66  N MET B 4   ? N MET B 4   
AA3 5 6 N TYR B 3   ? N TYR B 3   O ASN B 42  ? O ASN B 42  
AA3 6 7 N VAL B 41  ? N VAL B 41  O PHE C 52  ? O PHE C 52  
AA3 7 8 N LEU C 53  ? N LEU C 53  O VAL C 56  ? O VAL C 56  
# 
_pdbx_entry_details.entry_id                   9O2N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   C HOH 217 ? ? O   C HOH 236 ? ? 1.70 
2  1 OD2 B ASP 88  ? ? O   B HOH 201 ? ? 1.96 
3  1 O   B HOH 228 ? ? O   B HOH 239 ? ? 1.97 
4  1 NH1 B ARG 84  ? ? O   B HOH 202 ? ? 2.00 
5  1 OD1 C ASP 87  ? ? NH2 C ARG 97  ? ? 2.02 
6  1 OH  C TYR 6   ? ? O   C HOH 201 ? ? 2.08 
7  1 OD1 C ASN 131 ? ? O   C HOH 202 ? ? 2.12 
8  1 O   B ASP 145 ? ? O   B HOH 203 ? ? 2.12 
9  1 O   B HOH 219 ? ? O   B HOH 233 ? ? 2.13 
10 1 OD1 A ASN 131 ? ? O   A HOH 201 ? ? 2.15 
11 1 O   A HOH 214 ? ? O   A HOH 219 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 143 ? ? -92.93  52.17  
2 1 PRO B 122 ? ? -59.60  -6.98  
3 1 ASN B 143 ? ? -106.70 54.34  
4 1 SER C 134 ? ? -17.38  -65.17 
5 1 ASN C 143 ? ? -108.75 64.50  
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    B 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     235 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   E 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 x,-y,-z             
3 -x,y,-z+1/2         
4 -x,-y,z+1/2         
5 x+1/2,y+1/2,z       
6 x+1/2,-y+1/2,-z     
7 -x+1/2,y+1/2,-z+1/2 
8 -x+1/2,-y+1/2,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A VAL 146 ? A VAL 146 
2  1 Y 1 A SER 147 ? A SER 147 
3  1 Y 1 A ARG 148 ? A ARG 148 
4  1 Y 1 A THR 149 ? A THR 149 
5  1 Y 1 A GLU 150 ? A GLU 150 
6  1 Y 1 A ASN 151 ? A ASN 151 
7  1 Y 1 A LEU 152 ? A LEU 152 
8  1 Y 1 A TYR 153 ? A TYR 153 
9  1 Y 1 A PHE 154 ? A PHE 154 
10 1 Y 1 A GLN 155 ? A GLN 155 
11 1 Y 1 A GLY 156 ? A GLY 156 
12 1 Y 1 A LEU 157 ? A LEU 157 
13 1 Y 1 A GLU 158 ? A GLU 158 
14 1 Y 1 A HIS 159 ? A HIS 159 
15 1 Y 1 A HIS 160 ? A HIS 160 
16 1 Y 1 A HIS 161 ? A HIS 161 
17 1 Y 1 A HIS 162 ? A HIS 162 
18 1 Y 1 A HIS 163 ? A HIS 163 
19 1 Y 1 A HIS 164 ? A HIS 164 
20 1 Y 1 B VAL 146 ? B VAL 146 
21 1 Y 1 B SER 147 ? B SER 147 
22 1 Y 1 B ARG 148 ? B ARG 148 
23 1 Y 1 B THR 149 ? B THR 149 
24 1 Y 1 B GLU 150 ? B GLU 150 
25 1 Y 1 B ASN 151 ? B ASN 151 
26 1 Y 1 B LEU 152 ? B LEU 152 
27 1 Y 1 B TYR 153 ? B TYR 153 
28 1 Y 1 B PHE 154 ? B PHE 154 
29 1 Y 1 B GLN 155 ? B GLN 155 
30 1 Y 1 B GLY 156 ? B GLY 156 
31 1 Y 1 B LEU 157 ? B LEU 157 
32 1 Y 1 B GLU 158 ? B GLU 158 
33 1 Y 1 B HIS 159 ? B HIS 159 
34 1 Y 1 B HIS 160 ? B HIS 160 
35 1 Y 1 B HIS 161 ? B HIS 161 
36 1 Y 1 B HIS 162 ? B HIS 162 
37 1 Y 1 B HIS 163 ? B HIS 163 
38 1 Y 1 B HIS 164 ? B HIS 164 
39 1 Y 1 C VAL 146 ? C VAL 146 
40 1 Y 1 C SER 147 ? C SER 147 
41 1 Y 1 C ARG 148 ? C ARG 148 
42 1 Y 1 C THR 149 ? C THR 149 
43 1 Y 1 C GLU 150 ? C GLU 150 
44 1 Y 1 C ASN 151 ? C ASN 151 
45 1 Y 1 C LEU 152 ? C LEU 152 
46 1 Y 1 C TYR 153 ? C TYR 153 
47 1 Y 1 C PHE 154 ? C PHE 154 
48 1 Y 1 C GLN 155 ? C GLN 155 
49 1 Y 1 C GLY 156 ? C GLY 156 
50 1 Y 1 C LEU 157 ? C LEU 157 
51 1 Y 1 C GLU 158 ? C GLU 158 
52 1 Y 1 C HIS 159 ? C HIS 159 
53 1 Y 1 C HIS 160 ? C HIS 160 
54 1 Y 1 C HIS 161 ? C HIS 161 
55 1 Y 1 C HIS 162 ? C HIS 162 
56 1 Y 1 C HIS 163 ? C HIS 163 
57 1 Y 1 C HIS 164 ? C HIS 164 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
LEU N    N N N 169 
LEU CA   C N S 170 
LEU C    C N N 171 
LEU O    O N N 172 
LEU CB   C N N 173 
LEU CG   C N N 174 
LEU CD1  C N N 175 
LEU CD2  C N N 176 
LEU OXT  O N N 177 
LEU H    H N N 178 
LEU H2   H N N 179 
LEU HA   H N N 180 
LEU HB2  H N N 181 
LEU HB3  H N N 182 
LEU HG   H N N 183 
LEU HD11 H N N 184 
LEU HD12 H N N 185 
LEU HD13 H N N 186 
LEU HD21 H N N 187 
LEU HD22 H N N 188 
LEU HD23 H N N 189 
LEU HXT  H N N 190 
LYS N    N N N 191 
LYS CA   C N S 192 
LYS C    C N N 193 
LYS O    O N N 194 
LYS CB   C N N 195 
LYS CG   C N N 196 
LYS CD   C N N 197 
LYS CE   C N N 198 
LYS NZ   N N N 199 
LYS OXT  O N N 200 
LYS H    H N N 201 
LYS H2   H N N 202 
LYS HA   H N N 203 
LYS HB2  H N N 204 
LYS HB3  H N N 205 
LYS HG2  H N N 206 
LYS HG3  H N N 207 
LYS HD2  H N N 208 
LYS HD3  H N N 209 
LYS HE2  H N N 210 
LYS HE3  H N N 211 
LYS HZ1  H N N 212 
LYS HZ2  H N N 213 
LYS HZ3  H N N 214 
LYS HXT  H N N 215 
MET N    N N N 216 
MET CA   C N S 217 
MET C    C N N 218 
MET O    O N N 219 
MET CB   C N N 220 
MET CG   C N N 221 
MET SD   S N N 222 
MET CE   C N N 223 
MET OXT  O N N 224 
MET H    H N N 225 
MET H2   H N N 226 
MET HA   H N N 227 
MET HB2  H N N 228 
MET HB3  H N N 229 
MET HG2  H N N 230 
MET HG3  H N N 231 
MET HE1  H N N 232 
MET HE2  H N N 233 
MET HE3  H N N 234 
MET HXT  H N N 235 
PHE N    N N N 236 
PHE CA   C N S 237 
PHE C    C N N 238 
PHE O    O N N 239 
PHE CB   C N N 240 
PHE CG   C Y N 241 
PHE CD1  C Y N 242 
PHE CD2  C Y N 243 
PHE CE1  C Y N 244 
PHE CE2  C Y N 245 
PHE CZ   C Y N 246 
PHE OXT  O N N 247 
PHE H    H N N 248 
PHE H2   H N N 249 
PHE HA   H N N 250 
PHE HB2  H N N 251 
PHE HB3  H N N 252 
PHE HD1  H N N 253 
PHE HD2  H N N 254 
PHE HE1  H N N 255 
PHE HE2  H N N 256 
PHE HZ   H N N 257 
PHE HXT  H N N 258 
PRO N    N N N 259 
PRO CA   C N S 260 
PRO C    C N N 261 
PRO O    O N N 262 
PRO CB   C N N 263 
PRO CG   C N N 264 
PRO CD   C N N 265 
PRO OXT  O N N 266 
PRO H    H N N 267 
PRO HA   H N N 268 
PRO HB2  H N N 269 
PRO HB3  H N N 270 
PRO HG2  H N N 271 
PRO HG3  H N N 272 
PRO HD2  H N N 273 
PRO HD3  H N N 274 
PRO HXT  H N N 275 
SER N    N N N 276 
SER CA   C N S 277 
SER C    C N N 278 
SER O    O N N 279 
SER CB   C N N 280 
SER OG   O N N 281 
SER OXT  O N N 282 
SER H    H N N 283 
SER H2   H N N 284 
SER HA   H N N 285 
SER HB2  H N N 286 
SER HB3  H N N 287 
SER HG   H N N 288 
SER HXT  H N N 289 
THR N    N N N 290 
THR CA   C N S 291 
THR C    C N N 292 
THR O    O N N 293 
THR CB   C N R 294 
THR OG1  O N N 295 
THR CG2  C N N 296 
THR OXT  O N N 297 
THR H    H N N 298 
THR H2   H N N 299 
THR HA   H N N 300 
THR HB   H N N 301 
THR HG1  H N N 302 
THR HG21 H N N 303 
THR HG22 H N N 304 
THR HG23 H N N 305 
THR HXT  H N N 306 
TRP N    N N N 307 
TRP CA   C N S 308 
TRP C    C N N 309 
TRP O    O N N 310 
TRP CB   C N N 311 
TRP CG   C Y N 312 
TRP CD1  C Y N 313 
TRP CD2  C Y N 314 
TRP NE1  N Y N 315 
TRP CE2  C Y N 316 
TRP CE3  C Y N 317 
TRP CZ2  C Y N 318 
TRP CZ3  C Y N 319 
TRP CH2  C Y N 320 
TRP OXT  O N N 321 
TRP H    H N N 322 
TRP H2   H N N 323 
TRP HA   H N N 324 
TRP HB2  H N N 325 
TRP HB3  H N N 326 
TRP HD1  H N N 327 
TRP HE1  H N N 328 
TRP HE3  H N N 329 
TRP HZ2  H N N 330 
TRP HZ3  H N N 331 
TRP HH2  H N N 332 
TRP HXT  H N N 333 
TYR N    N N N 334 
TYR CA   C N S 335 
TYR C    C N N 336 
TYR O    O N N 337 
TYR CB   C N N 338 
TYR CG   C Y N 339 
TYR CD1  C Y N 340 
TYR CD2  C Y N 341 
TYR CE1  C Y N 342 
TYR CE2  C Y N 343 
TYR CZ   C Y N 344 
TYR OH   O N N 345 
TYR OXT  O N N 346 
TYR H    H N N 347 
TYR H2   H N N 348 
TYR HA   H N N 349 
TYR HB2  H N N 350 
TYR HB3  H N N 351 
TYR HD1  H N N 352 
TYR HD2  H N N 353 
TYR HE1  H N N 354 
TYR HE2  H N N 355 
TYR HH   H N N 356 
TYR HXT  H N N 357 
VAL N    N N N 358 
VAL CA   C N S 359 
VAL C    C N N 360 
VAL O    O N N 361 
VAL CB   C N N 362 
VAL CG1  C N N 363 
VAL CG2  C N N 364 
VAL OXT  O N N 365 
VAL H    H N N 366 
VAL H2   H N N 367 
VAL HA   H N N 368 
VAL HB   H N N 369 
VAL HG11 H N N 370 
VAL HG12 H N N 371 
VAL HG13 H N N 372 
VAL HG21 H N N 373 
VAL HG22 H N N 374 
VAL HG23 H N N 375 
VAL HXT  H N N 376 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3MF8 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 2 2 21' 
_space_group.name_Hall        'C 2c 2' 
_space_group.IT_number        20 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9O2N 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016490 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009948 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006802 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 1   ? -21.29400 -3.83200  -23.96700 1.000 26.48110 ? 1   PRO A N   1 
ATOM   2    C CA  . PRO A 1 1   ? -21.46300 -5.24000  -23.61500 1.000 24.76823 ? 1   PRO A CA  1 
ATOM   3    C C   . PRO A 1 1   ? -21.54500 -5.45800  -22.10900 1.000 23.43242 ? 1   PRO A C   1 
ATOM   4    O O   . PRO A 1 1   ? -21.28400 -4.55100  -21.31700 1.000 27.16506 ? 1   PRO A O   1 
ATOM   5    C CB  . PRO A 1 1   ? -20.20100 -5.89100  -24.18800 1.000 24.65766 ? 1   PRO A CB  1 
ATOM   6    C CG  . PRO A 1 1   ? -19.19600 -4.82300  -24.21800 1.000 21.33622 ? 1   PRO A CG  1 
ATOM   7    C CD  . PRO A 1 1   ? -19.87800 -3.49300  -24.20200 1.000 27.03161 ? 1   PRO A CD  1 
ATOM   8    N N   . VAL A 1 2   ? -21.92500 -6.66700  -21.73300 1.000 21.14662 ? 2   VAL A N   1 
ATOM   9    C CA  . VAL A 1 2   ? -21.84100 -7.14700  -20.35700 1.000 25.69415 ? 2   VAL A CA  1 
ATOM   10   C C   . VAL A 1 2   ? -21.02500 -8.43200  -20.40100 1.000 21.88835 ? 2   VAL A C   1 
ATOM   11   O O   . VAL A 1 2   ? -21.36200 -9.35000  -21.15200 1.000 24.37627 ? 2   VAL A O   1 
ATOM   12   C CB  . VAL A 1 2   ? -23.23300 -7.41400  -19.75200 1.000 22.56453 ? 2   VAL A CB  1 
ATOM   13   C CG1 . VAL A 1 2   ? -23.11200 -8.24000  -18.46700 1.000 21.83495 ? 2   VAL A CG1 1 
ATOM   14   C CG2 . VAL A 1 2   ? -24.01300 -6.11500  -19.53700 1.000 19.09783 ? 2   VAL A CG2 1 
ATOM   15   N N   . TYR A 1 3   ? -19.95000 -8.49600  -19.63400 1.000 20.93475 ? 3   TYR A N   1 
ATOM   16   C CA  . TYR A 1 3   ? -19.21000 -9.74000  -19.46000 1.000 22.76745 ? 3   TYR A CA  1 
ATOM   17   C C   . TYR A 1 3   ? -19.54800 -10.30900 -18.08200 1.000 25.30091 ? 3   TYR A C   1 
ATOM   18   O O   . TYR A 1 3   ? -19.14500 -9.74400  -17.06200 1.000 26.04389 ? 3   TYR A O   1 
ATOM   19   C CB  . TYR A 1 3   ? -17.70500 -9.51000  -19.61200 1.000 24.92459 ? 3   TYR A CB  1 
ATOM   20   C CG  . TYR A 1 3   ? -17.25000 -9.23100  -21.04100 1.000 22.90533 ? 3   TYR A CG  1 
ATOM   21   C CD1 . TYR A 1 3   ? -16.93600 -10.27000 -21.90700 1.000 23.89042 ? 3   TYR A CD1 1 
ATOM   22   C CD2 . TYR A 1 3   ? -17.14800 -7.92000  -21.51700 1.000 19.80841 ? 3   TYR A CD2 1 
ATOM   23   C CE1 . TYR A 1 3   ? -16.51900 -10.01200 -23.21200 1.000 26.39504 ? 3   TYR A CE1 1 
ATOM   24   C CE2 . TYR A 1 3   ? -16.73000 -7.65300  -22.81200 1.000 21.03519 ? 3   TYR A CE2 1 
ATOM   25   C CZ  . TYR A 1 3   ? -16.42100 -8.69600  -23.65300 1.000 22.79791 ? 3   TYR A CZ  1 
ATOM   26   O OH  . TYR A 1 3   ? -16.01400 -8.43000  -24.92600 1.000 27.98554 ? 3   TYR A OH  1 
ATOM   27   N N   . MET A 1 4   ? -20.30300 -11.40900 -18.05800 1.000 23.41423 ? 4   MET A N   1 
ATOM   28   C CA  . MET A 1 4   ? -20.52700 -12.20300 -16.85300 1.000 23.97080 ? 4   MET A CA  1 
ATOM   29   C C   . MET A 1 4   ? -19.31500 -13.10100 -16.61200 1.000 25.52175 ? 4   MET A C   1 
ATOM   30   O O   . MET A 1 4   ? -18.97500 -13.91600 -17.47100 1.000 22.97475 ? 4   MET A O   1 
ATOM   31   C CB  . MET A 1 4   ? -21.77400 -13.06700 -17.04500 1.000 24.84983 ? 4   MET A CB  1 
ATOM   32   C CG  . MET A 1 4   ? -23.11900 -12.34300 -17.07400 1.000 27.69116 ? 4   MET A CG  1 
ATOM   33   S SD  . MET A 1 4   ? -23.32300 -10.80600 -16.15800 1.000 27.81098 ? 4   MET A SD  1 
ATOM   34   C CE  . MET A 1 4   ? -23.45100 -11.45300 -14.46300 1.000 26.99896 ? 4   MET A CE  1 
ATOM   35   N N   . VAL A 1 5   ? -18.68200 -12.99600 -15.45200 1.000 22.91816 ? 5   VAL A N   1 
ATOM   36   C CA  . VAL A 1 5   ? -17.48500 -13.78300 -15.17400 1.000 25.88219 ? 5   VAL A CA  1 
ATOM   37   C C   . VAL A 1 5   ? -17.75000 -14.69500 -13.98100 1.000 23.92194 ? 5   VAL A C   1 
ATOM   38   O O   . VAL A 1 5   ? -17.88800 -14.22500 -12.84300 1.000 20.96802 ? 5   VAL A O   1 
ATOM   39   C CB  . VAL A 1 5   ? -16.25300 -12.90500 -14.92000 1.000 26.99225 ? 5   VAL A CB  1 
ATOM   40   C CG1 . VAL A 1 5   ? -15.00500 -13.79900 -14.84600 1.000 25.93233 ? 5   VAL A CG1 1 
ATOM   41   C CG2 . VAL A 1 5   ? -16.11100 -11.83300 -16.01200 1.000 22.00980 ? 5   VAL A CG2 1 
ATOM   42   N N   . TYR A 1 6   ? -17.76500 -16.00500 -14.22700 1.000 22.56728 ? 6   TYR A N   1 
ATOM   43   C CA  . TYR A 1 6   ? -18.07300 -16.98200 -13.19200 1.000 27.60339 ? 6   TYR A CA  1 
ATOM   44   C C   . TYR A 1 6   ? -16.76600 -17.52700 -12.62800 1.000 24.78029 ? 6   TYR A C   1 
ATOM   45   O O   . TYR A 1 6   ? -16.01700 -18.21600 -13.32000 1.000 27.33513 ? 6   TYR A O   1 
ATOM   46   C CB  . TYR A 1 6   ? -18.98200 -18.07700 -13.75200 1.000 23.65919 ? 6   TYR A CB  1 
ATOM   47   C CG  . TYR A 1 6   ? -20.22700 -17.46300 -14.33300 1.000 26.14421 ? 6   TYR A CG  1 
ATOM   48   C CD1 . TYR A 1 6   ? -21.34300 -17.24200 -13.53500 1.000 26.66069 ? 6   TYR A CD1 1 
ATOM   49   C CD2 . TYR A 1 6   ? -20.26100 -17.02300 -15.65300 1.000 22.19763 ? 6   TYR A CD2 1 
ATOM   50   C CE1 . TYR A 1 6   ? -22.48300 -16.63400 -14.03900 1.000 27.28569 ? 6   TYR A CE1 1 
ATOM   51   C CE2 . TYR A 1 6   ? -21.39300 -16.43400 -16.17400 1.000 23.92478 ? 6   TYR A CE2 1 
ATOM   52   C CZ  . TYR A 1 6   ? -22.50600 -16.24400 -15.37200 1.000 29.01594 ? 6   TYR A CZ  1 
ATOM   53   O OH  . TYR A 1 6   ? -23.63800 -15.63200 -15.88100 1.000 23.74779 ? 6   TYR A OH  1 
ATOM   54   N N   . VAL A 1 7   ? -16.48800 -17.19400 -11.37000 1.000 24.07182 ? 7   VAL A N   1 
ATOM   55   C CA  . VAL A 1 7   ? -15.27900 -17.63200 -10.69300 1.000 28.68848 ? 7   VAL A CA  1 
ATOM   56   C C   . VAL A 1 7   ? -15.65300 -18.14500 -9.31200  1.000 33.61846 ? 7   VAL A C   1 
ATOM   57   O O   . VAL A 1 7   ? -16.75100 -17.91200 -8.80800  1.000 30.45899 ? 7   VAL A O   1 
ATOM   58   C CB  . VAL A 1 7   ? -14.23500 -16.51000 -10.58400 1.000 31.93575 ? 7   VAL A CB  1 
ATOM   59   C CG1 . VAL A 1 7   ? -13.64400 -16.21200 -11.95400 1.000 28.18315 ? 7   VAL A CG1 1 
ATOM   60   C CG2 . VAL A 1 7   ? -14.86600 -15.27600 -10.00000 1.000 27.92216 ? 7   VAL A CG2 1 
ATOM   61   N N   . SER A 1 8   ? -14.71500 -18.85700 -8.70300  1.000 35.34905 ? 8   SER A N   1 
ATOM   62   C CA  . SER A 1 8   ? -14.94000 -19.38500 -7.36900  1.000 35.82052 ? 8   SER A CA  1 
ATOM   63   C C   . SER A 1 8   ? -14.67000 -18.32300 -6.31200  1.000 33.84894 ? 8   SER A C   1 
ATOM   64   O O   . SER A 1 8   ? -13.84500 -17.42100 -6.49600  1.000 33.20292 ? 8   SER A O   1 
ATOM   65   C CB  . SER A 1 8   ? -14.07100 -20.61500 -7.11400  1.000 33.76583 ? 8   SER A CB  1 
ATOM   66   O OG  . SER A 1 8   ? -14.56500 -21.72700 -7.83400  1.000 32.57200 ? 8   SER A OG  1 
ATOM   67   N N   . GLN A 1 9   ? -15.39700 -18.44300 -5.20200  1.000 34.04931 ? 9   GLN A N   1 
ATOM   68   C CA  . GLN A 1 9   ? -15.22100 -17.56300 -4.05800  1.000 38.83804 ? 9   GLN A CA  1 
ATOM   69   C C   . GLN A 1 9   ? -13.77700 -17.59800 -3.57000  1.000 38.50619 ? 9   GLN A C   1 
ATOM   70   O O   . GLN A 1 9   ? -13.15000 -18.65900 -3.52800  1.000 34.98431 ? 9   GLN A O   1 
ATOM   71   C CB  . GLN A 1 9   ? -16.17000 -17.99800 -2.93900  1.000 38.20337 ? 9   GLN A CB  1 
ATOM   72   C CG  . GLN A 1 9   ? -16.10700 -17.11800 -1.71900  1.000 46.74569 ? 9   GLN A CG  1 
ATOM   73   C CD  . GLN A 1 9   ? -16.60800 -15.72400 -2.01400  1.000 54.01908 ? 9   GLN A CD  1 
ATOM   74   O OE1 . GLN A 1 9   ? -15.99900 -14.73000 -1.60200  1.000 55.36354 ? 9   GLN A OE1 1 
ATOM   75   N NE2 . GLN A 1 9   ? -17.72200 -15.63900 -2.75200  1.000 54.74876 ? 9   GLN A NE2 1 
ATOM   76   N N   . ASP A 1 10  ? -13.24500 -16.42400 -3.23000  1.000 39.86250 ? 10  ASP A N   1 
ATOM   77   C CA  . ASP A 1 10  ? -11.89600 -16.27600 -2.68300  1.000 40.53271 ? 10  ASP A CA  1 
ATOM   78   C C   . ASP A 1 10  ? -10.81300 -16.77600 -3.62000  1.000 42.41206 ? 10  ASP A C   1 
ATOM   79   O O   . ASP A 1 10  ? -9.71500  -17.10900 -3.16600  1.000 51.19962 ? 10  ASP A O   1 
ATOM   80   C CB  . ASP A 1 10  ? -11.74100 -16.97400 -1.33400  1.000 44.66826 ? 10  ASP A CB  1 
ATOM   81   C CG  . ASP A 1 10  ? -12.68600 -16.43600 -0.30100  1.000 46.66703 ? 10  ASP A CG  1 
ATOM   82   O OD1 . ASP A 1 10  ? -12.89300 -15.20400 -0.28700  1.000 43.61147 ? 10  ASP A OD1 1 
ATOM   83   O OD2 . ASP A 1 10  ? -13.22200 -17.23300 0.48800   1.000 52.05689 ? 10  ASP A OD2 1 
ATOM   84   N N   . ARG A 1 11  ? -11.09300 -16.85500 -4.92000  1.000 37.03424 ? 11  ARG A N   1 
ATOM   85   C CA  . ARG A 1 11  ? -10.04600 -17.15300 -5.88100  1.000 36.49677 ? 11  ARG A CA  1 
ATOM   86   C C   . ARG A 1 11  ? -9.44200  -15.88900 -6.45900  1.000 38.92456 ? 11  ARG A C   1 
ATOM   87   O O   . ARG A 1 11  ? -8.26000  -15.88100 -6.80900  1.000 40.39429 ? 11  ARG A O   1 
ATOM   88   C CB  . ARG A 1 11  ? -10.59500 -18.01900 -7.01100  1.000 42.46712 ? 11  ARG A CB  1 
ATOM   89   C CG  . ARG A 1 11  ? -9.52700  -18.50000 -7.98000  1.000 42.72626 ? 11  ARG A CG  1 
ATOM   90   C CD  . ARG A 1 11  ? -8.47800  -19.29100 -7.24400  1.000 45.23308 ? 11  ARG A CD  1 
ATOM   91   N NE  . ARG A 1 11  ? -7.41800  -19.74200 -8.13200  1.000 50.66494 ? 11  ARG A NE  1 
ATOM   92   C CZ  . ARG A 1 11  ? -6.40600  -18.98300 -8.52400  1.000 50.54931 ? 11  ARG A CZ  1 
ATOM   93   N NH1 . ARG A 1 11  ? -6.30400  -17.71900 -8.14200  1.000 48.70197 ? 11  ARG A NH1 1 
ATOM   94   N NH2 . ARG A 1 11  ? -5.47200  -19.50800 -9.31600  1.000 55.93973 ? 11  ARG A NH2 1 
ATOM   95   N N   . LEU A 1 12  ? -10.22700 -14.82100 -6.56300  1.000 38.39936 ? 12  LEU A N   1 
ATOM   96   C CA  . LEU A 1 12  ? -9.73400  -13.50800 -6.95200  1.000 34.54703 ? 12  LEU A CA  1 
ATOM   97   C C   . LEU A 1 12  ? -9.84200  -12.54300 -5.77800  1.000 41.64979 ? 12  LEU A C   1 
ATOM   98   O O   . LEU A 1 12  ? -10.93300 -12.32100 -5.24000  1.000 43.31712 ? 12  LEU A O   1 
ATOM   99   C CB  . LEU A 1 12  ? -10.49700 -12.95000 -8.15400  1.000 29.78985 ? 12  LEU A CB  1 
ATOM   100  C CG  . LEU A 1 12  ? -10.48100 -13.74400 -9.45400  1.000 29.66326 ? 12  LEU A CG  1 
ATOM   101  C CD1 . LEU A 1 12  ? -11.16100 -12.94500 -10.54200 1.000 30.82111 ? 12  LEU A CD1 1 
ATOM   102  C CD2 . LEU A 1 12  ? -9.06300  -14.07600 -9.86900  1.000 33.04177 ? 12  LEU A CD2 1 
ATOM   103  N N   . THR A 1 13  ? -8.70600  -11.96800 -5.39000  1.000 39.06334 ? 13  THR A N   1 
ATOM   104  C CA  . THR A 1 13  ? -8.68100  -10.84800 -4.47000  1.000 39.45869 ? 13  THR A CA  1 
ATOM   105  C C   . THR A 1 13  ? -9.34300  -9.63400  -5.11900  1.000 41.25217 ? 13  THR A C   1 
ATOM   106  O O   . THR A 1 13  ? -9.58300  -9.61800  -6.33300  1.000 40.05410 ? 13  THR A O   1 
ATOM   107  C CB  . THR A 1 13  ? -7.24100  -10.51000 -4.08800  1.000 41.58869 ? 13  THR A CB  1 
ATOM   108  O OG1 . THR A 1 13  ? -6.62800  -9.77700  -5.16000  1.000 38.73678 ? 13  THR A OG1 1 
ATOM   109  C CG2 . THR A 1 13  ? -6.43100  -11.78300 -3.79300  1.000 43.18354 ? 13  THR A CG2 1 
ATOM   110  N N   . PRO A 1 14  ? -9.67200  -8.60500  -4.32600  1.000 37.62736 ? 14  PRO A N   1 
ATOM   111  C CA  . PRO A 1 14  ? -10.10600 -7.33400  -4.92700  1.000 34.40336 ? 14  PRO A CA  1 
ATOM   112  C C   . PRO A 1 14  ? -9.20700  -6.84600  -6.04400  1.000 40.03058 ? 14  PRO A C   1 
ATOM   113  O O   . PRO A 1 14  ? -9.69500  -6.44800  -7.11300  1.000 39.27273 ? 14  PRO A O   1 
ATOM   114  C CB  . PRO A 1 14  ? -10.09400 -6.37700  -3.73000  1.000 34.71877 ? 14  PRO A CB  1 
ATOM   115  C CG  . PRO A 1 14  ? -10.45700 -7.23600  -2.58200  1.000 37.65846 ? 14  PRO A CG  1 
ATOM   116  C CD  . PRO A 1 14  ? -9.87400  -8.60700  -2.86300  1.000 37.55016 ? 14  PRO A CD  1 
ATOM   117  N N   . SER A 1 15  ? -7.89800  -6.86800  -5.83100  1.000 36.73595 ? 15  SER A N   1 
ATOM   118  C CA  . SER A 1 15  ? -7.01300  -6.33300  -6.85300  1.000 35.26207 ? 15  SER A CA  1 
ATOM   119  C C   . SER A 1 15  ? -7.02800  -7.20800  -8.09900  1.000 36.92074 ? 15  SER A C   1 
ATOM   120  O O   . SER A 1 15  ? -6.96800  -6.69700  -9.22400  1.000 36.42333 ? 15  SER A O   1 
ATOM   121  C CB  . SER A 1 15  ? -5.59400  -6.19600  -6.29000  1.000 34.29539 ? 15  SER A CB  1 
ATOM   122  O OG  . SER A 1 15  ? -4.87300  -7.40200  -6.45900  1.000 42.56408 ? 15  SER A OG  1 
ATOM   123  N N   . ALA A 1 16  ? -7.10900  -8.53100  -7.91800  1.000 34.55344 ? 16  ALA A N   1 
ATOM   124  C CA  . ALA A 1 16  ? -7.12700  -9.43500  -9.06200  1.000 37.41179 ? 16  ALA A CA  1 
ATOM   125  C C   . ALA A 1 16  ? -8.40700  -9.26100  -9.88000  1.000 36.19267 ? 16  ALA A C   1 
ATOM   126  O O   . ALA A 1 16  ? -8.36500  -9.27500  -11.11700 1.000 30.30898 ? 16  ALA A O   1 
ATOM   127  C CB  . ALA A 1 16  ? -6.97400  -10.88700 -8.59100  1.000 34.29887 ? 16  ALA A CB  1 
ATOM   128  N N   . LYS A 1 17  ? -9.55300  -9.12700  -9.20100  1.000 34.89279 ? 17  LYS A N   1 
ATOM   129  C CA  . LYS A 1 17  ? -10.81000 -8.82700  -9.88100  1.000 35.81308 ? 17  LYS A CA  1 
ATOM   130  C C   . LYS A 1 17  ? -10.67500 -7.57600  -10.72400 1.000 35.66862 ? 17  LYS A C   1 
ATOM   131  O O   . LYS A 1 17  ? -11.16800 -7.52000  -11.85100 1.000 34.32821 ? 17  LYS A O   1 
ATOM   132  C CB  . LYS A 1 17  ? -11.93600 -8.62900  -8.86400  1.000 33.88242 ? 17  LYS A CB  1 
ATOM   133  C CG  . LYS A 1 17  ? -12.52500 -9.89700  -8.28500  1.000 34.62608 ? 17  LYS A CG  1 
ATOM   134  C CD  . LYS A 1 17  ? -13.26300 -9.55400  -6.99700  1.000 36.94004 ? 17  LYS A CD  1 
ATOM   135  C CE  . LYS A 1 17  ? -13.75400 -10.78900 -6.26800  1.000 37.98641 ? 17  LYS A CE  1 
ATOM   136  N NZ  . LYS A 1 17  ? -14.89900 -10.48100 -5.36700  1.000 36.57908 ? 17  LYS A NZ  1 
ATOM   137  N N   . HIS A 1 18  ? -10.01000 -6.55700  -10.18400 1.000 33.70690 ? 18  HIS A N   1 
ATOM   138  C CA  . HIS A 1 18  ? -9.80300  -5.33200  -10.93800 1.000 33.03591 ? 18  HIS A CA  1 
ATOM   139  C C   . HIS A 1 18  ? -8.98500  -5.60000  -12.19800 1.000 37.65091 ? 18  HIS A C   1 
ATOM   140  O O   . HIS A 1 18  ? -9.37300  -5.20000  -13.30400 1.000 35.39095 ? 18  HIS A O   1 
ATOM   141  C CB  . HIS A 1 18  ? -9.12900  -4.28500  -10.04700 1.000 39.57508 ? 18  HIS A CB  1 
ATOM   142  C CG  . HIS A 1 18  ? -8.86300  -2.99300  -10.75000 1.000 45.45567 ? 18  HIS A CG  1 
ATOM   143  N ND1 . HIS A 1 18  ? -9.67100  -1.88800  -10.60300 1.000 42.65857 ? 18  HIS A ND1 1 
ATOM   144  C CD2 . HIS A 1 18  ? -7.89000  -2.63700  -11.62400 1.000 50.16648 ? 18  HIS A CD2 1 
ATOM   145  C CE1 . HIS A 1 18  ? -9.20300  -0.90100  -11.34600 1.000 44.32493 ? 18  HIS A CE1 1 
ATOM   146  N NE2 . HIS A 1 18  ? -8.12400  -1.33000  -11.97900 1.000 53.33411 ? 18  HIS A NE2 1 
ATOM   147  N N   . ALA A 1 19  ? -7.85700  -6.30400  -12.05100 1.000 35.22860 ? 19  ALA A N   1 
ATOM   148  C CA  . ALA A 1 19  ? -7.00400  -6.58300  -13.19900 1.000 30.17849 ? 19  ALA A CA  1 
ATOM   149  C C   . ALA A 1 19  ? -7.75100  -7.39200  -14.24800 1.000 28.48507 ? 19  ALA A C   1 
ATOM   150  O O   . ALA A 1 19  ? -7.66700  -7.09900  -15.44300 1.000 28.95626 ? 19  ALA A O   1 
ATOM   151  C CB  . ALA A 1 19  ? -5.73800  -7.31400  -12.75400 1.000 31.19392 ? 19  ALA A CB  1 
ATOM   152  N N   . VAL A 1 20  ? -8.48700  -8.41500  -13.83000 1.000 30.04446 ? 20  VAL A N   1 
ATOM   153  C CA  . VAL A 1 20  ? -9.25300  -9.18700  -14.80700 1.000 32.63730 ? 20  VAL A CA  1 
ATOM   154  C C   . VAL A 1 20  ? -10.29100 -8.29800  -15.48500 1.000 32.77457 ? 20  VAL A C   1 
ATOM   155  O O   . VAL A 1 20  ? -10.48000 -8.35500  -16.70700 1.000 32.85692 ? 20  VAL A O   1 
ATOM   156  C CB  . VAL A 1 20  ? -9.89800  -10.41500 -14.14100 1.000 28.85745 ? 20  VAL A CB  1 
ATOM   157  C CG1 . VAL A 1 20  ? -10.90500 -11.04000 -15.08100 1.000 31.26836 ? 20  VAL A CG1 1 
ATOM   158  C CG2 . VAL A 1 20  ? -8.83400  -11.41800 -13.77600 1.000 27.10386 ? 20  VAL A CG2 1 
ATOM   159  N N   . ALA A 1 21  ? -10.95900 -7.44100  -14.70600 1.000 32.16548 ? 21  ALA A N   1 
ATOM   160  C CA  . ALA A 1 21  ? -11.93200 -6.52700  -15.28900 1.000 33.15143 ? 21  ALA A CA  1 
ATOM   161  C C   . ALA A 1 21  ? -11.26200 -5.53200  -16.23900 1.000 32.97302 ? 21  ALA A C   1 
ATOM   162  O O   . ALA A 1 21  ? -11.84700 -5.17000  -17.26700 1.000 30.49477 ? 21  ALA A O   1 
ATOM   163  C CB  . ALA A 1 21  ? -12.69700 -5.80200  -14.17800 1.000 28.19669 ? 21  ALA A CB  1 
ATOM   164  N N   . LYS A 1 22  ? -10.03300 -5.08900  -15.92300 1.000 27.05078 ? 22  LYS A N   1 
ATOM   165  C CA  . LYS A 1 22  ? -9.31300  -4.19500  -16.82700 1.000 30.03177 ? 22  LYS A CA  1 
ATOM   166  C C   . LYS A 1 22  ? -8.88500  -4.92600  -18.08800 1.000 31.97267 ? 22  LYS A C   1 
ATOM   167  O O   . LYS A 1 22  ? -8.98200  -4.37300  -19.18600 1.000 30.68815 ? 22  LYS A O   1 
ATOM   168  C CB  . LYS A 1 22  ? -8.07300  -3.58600  -16.16100 1.000 36.71910 ? 22  LYS A CB  1 
ATOM   169  C CG  . LYS A 1 22  ? -8.32100  -2.48600  -15.09900 1.000 38.76488 ? 22  LYS A CG  1 
ATOM   170  C CD  . LYS A 1 22  ? -9.36900  -1.47300  -15.54100 1.000 47.12920 ? 22  LYS A CD  1 
ATOM   171  C CE  . LYS A 1 22  ? -9.06900  -0.80300  -16.91700 1.000 47.93655 ? 22  LYS A CE  1 
ATOM   172  N NZ  . LYS A 1 22  ? -8.42700  0.54000   -16.82500 1.000 54.59711 ? 22  LYS A NZ  1 
ATOM   173  N N   . ALA A 1 23  ? -8.37600  -6.15600  -17.94300 1.000 30.54427 ? 23  ALA A N   1 
ATOM   174  C CA  . ALA A 1 23  ? -7.97900  -6.96700  -19.08900 1.000 32.20496 ? 23  ALA A CA  1 
ATOM   175  C C   . ALA A 1 23  ? -9.11500  -7.08400  -20.10000 1.000 31.98053 ? 23  ALA A C   1 
ATOM   176  O O   . ALA A 1 23  ? -8.93400  -6.82700  -21.29400 1.000 30.66974 ? 23  ALA A O   1 
ATOM   177  C CB  . ALA A 1 23  ? -7.54800  -8.35100  -18.61200 1.000 28.05016 ? 23  ALA A CB  1 
ATOM   178  N N   . ILE A 1 24  ? -10.30800 -7.44200  -19.62200 1.000 31.01839 ? 24  ILE A N   1 
ATOM   179  C CA  . ILE A 1 24  ? -11.45800 -7.62000  -20.50500 1.000 28.65863 ? 24  ILE A CA  1 
ATOM   180  C C   . ILE A 1 24  ? -11.87300 -6.28700  -21.11900 1.000 27.15432 ? 24  ILE A C   1 
ATOM   181  O O   . ILE A 1 24  ? -12.05100 -6.18000  -22.33600 1.000 29.68531 ? 24  ILE A O   1 
ATOM   182  C CB  . ILE A 1 24  ? -12.61100 -8.29700  -19.73600 1.000 25.96488 ? 24  ILE A CB  1 
ATOM   183  C CG1 . ILE A 1 24  ? -12.17300 -9.70700  -19.29600 1.000 23.77616 ? 24  ILE A CG1 1 
ATOM   184  C CG2 . ILE A 1 24  ? -13.87500 -8.36100  -20.58800 1.000 21.22746 ? 24  ILE A CG2 1 
ATOM   185  C CD1 . ILE A 1 24  ? -13.12800 -10.38600 -18.28500 1.000 24.35856 ? 24  ILE A CD1 1 
ATOM   186  N N   . THR A 1 25  ? -11.99800 -5.24400  -20.29600 1.000 30.27991 ? 25  THR A N   1 
ATOM   187  C CA  . THR A 1 25  ? -12.45400 -3.95000  -20.80500 1.000 29.92976 ? 25  THR A CA  1 
ATOM   188  C C   . THR A 1 25  ? -11.49900 -3.40200  -21.85400 1.000 31.01260 ? 25  THR A C   1 
ATOM   189  O O   . THR A 1 25  ? -11.94100 -2.88400  -22.88800 1.000 31.18994 ? 25  THR A O   1 
ATOM   190  C CB  . THR A 1 25  ? -12.62000 -2.94100  -19.65900 1.000 28.49248 ? 25  THR A CB  1 
ATOM   191  O OG1 . THR A 1 25  ? -13.39400 -3.52300  -18.61200 1.000 28.06032 ? 25  THR A OG1 1 
ATOM   192  C CG2 . THR A 1 25  ? -13.32800 -1.67700  -20.12800 1.000 29.75592 ? 25  THR A CG2 1 
ATOM   193  N N   . ASP A 1 26  ? -10.18100 -3.50400  -21.59800 1.000 28.40653 ? 26  ASP A N   1 
ATOM   194  C CA  . ASP A 1 26  ? -9.16300  -3.05300  -22.55000 1.000 29.66174 ? 26  ASP A CA  1 
ATOM   195  C C   . ASP A 1 26  ? -9.17100  -3.90500  -23.81300 1.000 30.92404 ? 26  ASP A C   1 
ATOM   196  O O   . ASP A 1 26  ? -9.06200  -3.37100  -24.92000 1.000 31.32132 ? 26  ASP A O   1 
ATOM   197  C CB  . ASP A 1 26  ? -7.75900  -3.08400  -21.91500 1.000 32.95940 ? 26  ASP A CB  1 
ATOM   198  C CG  . ASP A 1 26  ? -7.54000  -1.99100  -20.85200 1.000 41.10793 ? 26  ASP A CG  1 
ATOM   199  O OD1 . ASP A 1 26  ? -8.38400  -1.09200  -20.69800 1.000 39.54015 ? 26  ASP A OD1 1 
ATOM   200  O OD2 . ASP A 1 26  ? -6.50200  -2.03600  -20.15700 1.000 43.43266 ? 26  ASP A OD2 1 
ATOM   201  N N   . ALA A 1 27  ? -9.28300  -5.22900  -23.66900 1.000 31.22414 ? 27  ALA A N   1 
ATOM   202  C CA  . ALA A 1 27  ? -9.33700  -6.09200  -24.84800 1.000 32.65585 ? 27  ALA A CA  1 
ATOM   203  C C   . ALA A 1 27  ? -10.53500 -5.74200  -25.72400 1.000 34.65198 ? 27  ALA A C   1 
ATOM   204  O O   . ALA A 1 27  ? -10.40500 -5.54100  -26.93600 1.000 33.35800 ? 27  ALA A O   1 
ATOM   205  C CB  . ALA A 1 27  ? -9.39500  -7.55400  -24.42200 1.000 30.40791 ? 27  ALA A CB  1 
ATOM   206  N N   . HIS A 1 28  ? -11.71000 -5.62700  -25.10800 1.000 34.89841 ? 28  HIS A N   1 
ATOM   207  C CA  . HIS A 1 28  ? -12.90800 -5.22600  -25.82700 1.000 30.76118 ? 28  HIS A CA  1 
ATOM   208  C C   . HIS A 1 28  ? -12.74000 -3.86900  -26.50600 1.000 31.31421 ? 28  HIS A C   1 
ATOM   209  O O   . HIS A 1 28  ? -13.10400 -3.69700  -27.67800 1.000 29.63533 ? 28  HIS A O   1 
ATOM   210  C CB  . HIS A 1 28  ? -14.08900 -5.19500  -24.86600 1.000 30.06021 ? 28  HIS A CB  1 
ATOM   211  C CG  . HIS A 1 28  ? -15.39600 -5.10600  -25.56700 1.000 28.54630 ? 28  HIS A CG  1 
ATOM   212  N ND1 . HIS A 1 28  ? -16.12000 -6.22500  -25.92300 1.000 24.97393 ? 28  HIS A ND1 1 
ATOM   213  C CD2 . HIS A 1 28  ? -16.07600 -4.04000  -26.04500 1.000 28.93471 ? 28  HIS A CD2 1 
ATOM   214  C CE1 . HIS A 1 28  ? -17.20700 -5.84700  -26.56800 1.000 29.01548 ? 28  HIS A CE1 1 
ATOM   215  N NE2 . HIS A 1 28  ? -17.20300 -4.52700  -26.65700 1.000 30.97394 ? 28  HIS A NE2 1 
ATOM   216  N N   . ARG A 1 29  ? -12.21200 -2.88400  -25.78000 1.000 31.35517 ? 29  ARG A N   1 
ATOM   217  C CA  . ARG A 1 29  ? -12.11200 -1.53500  -26.33900 1.000 37.47700 ? 29  ARG A CA  1 
ATOM   218  C C   . ARG A 1 29  ? -11.05600 -1.46700  -27.44200 1.000 33.62496 ? 29  ARG A C   1 
ATOM   219  O O   . ARG A 1 29  ? -11.28100 -0.85000  -28.49700 1.000 29.52057 ? 29  ARG A O   1 
ATOM   220  C CB  . ARG A 1 29  ? -11.81000 -0.52100  -25.22700 1.000 34.30941 ? 29  ARG A CB  1 
ATOM   221  C CG  . ARG A 1 29  ? -10.92300 0.63100   -25.65700 1.000 30.57411 ? 29  ARG A CG  1 
ATOM   222  C CD  . ARG A 1 29  ? -11.72200 1.88600   -26.00300 1.000 35.59366 ? 29  ARG A CD  1 
ATOM   223  N NE  . ARG A 1 29  ? -10.84000 2.92600   -26.52600 1.000 45.18469 ? 29  ARG A NE  1 
ATOM   224  C CZ  . ARG A 1 29  ? -11.23500 4.06600   -27.07500 1.000 45.21794 ? 29  ARG A CZ  1 
ATOM   225  N NH1 . ARG A 1 29  ? -12.52100 4.36500   -27.21600 1.000 45.23404 ? 29  ARG A NH1 1 
ATOM   226  N NH2 . ARG A 1 29  ? -10.31600 4.93200   -27.49100 1.000 48.64901 ? 29  ARG A NH2 1 
ATOM   227  N N   . GLY A 1 30  ? -9.90100  -2.09400  -27.22200 1.000 33.45074 ? 30  GLY A N   1 
ATOM   228  C CA  . GLY A 1 30  ? -8.89900  -2.14200  -28.27500 1.000 34.52304 ? 30  GLY A CA  1 
ATOM   229  C C   . GLY A 1 30  ? -9.46300  -2.70000  -29.56600 1.000 34.27683 ? 30  GLY A C   1 
ATOM   230  O O   . GLY A 1 30  ? -9.32300  -2.10600  -30.63200 1.000 34.16669 ? 30  GLY A O   1 
ATOM   231  N N   . LEU A 1 31  ? -10.17500 -3.81100  -29.47100 1.000 34.83247 ? 31  LEU A N   1 
ATOM   232  C CA  . LEU A 1 31  ? -10.57400 -4.53800  -30.66300 1.000 34.58882 ? 31  LEU A CA  1 
ATOM   233  C C   . LEU A 1 31  ? -11.86200 -4.02700  -31.28900 1.000 32.12150 ? 31  LEU A C   1 
ATOM   234  O O   . LEU A 1 31  ? -12.01400 -4.12000  -32.50800 1.000 29.77608 ? 31  LEU A O   1 
ATOM   235  C CB  . LEU A 1 31  ? -10.70600 -6.02100  -30.34000 1.000 30.87143 ? 31  LEU A CB  1 
ATOM   236  C CG  . LEU A 1 31  ? -9.34900  -6.67600  -30.51300 1.000 31.54117 ? 31  LEU A CG  1 
ATOM   237  C CD1 . LEU A 1 31  ? -9.30900  -8.01800  -29.81200 1.000 34.08068 ? 31  LEU A CD1 1 
ATOM   238  C CD2 . LEU A 1 31  ? -9.09400  -6.82600  -32.00400 1.000 28.76342 ? 31  LEU A CD2 1 
ATOM   239  N N   . THR A 1 32  ? -12.79400 -3.49200  -30.50500 1.000 33.19065 ? 32  THR A N   1 
ATOM   240  C CA  . THR A 1 32  ? -14.07400 -3.06300  -31.06100 1.000 29.11196 ? 32  THR A CA  1 
ATOM   241  C C   . THR A 1 32  ? -14.20600 -1.55900  -31.21500 1.000 29.78756 ? 32  THR A C   1 
ATOM   242  O O   . THR A 1 32  ? -14.94300 -1.10200  -32.09600 1.000 27.53678 ? 32  THR A O   1 
ATOM   243  C CB  . THR A 1 32  ? -15.23200 -3.54600  -30.19000 1.000 32.05268 ? 32  THR A CB  1 
ATOM   244  O OG1 . THR A 1 32  ? -15.23600 -2.82500  -28.95200 1.000 36.00277 ? 32  THR A OG1 1 
ATOM   245  C CG2 . THR A 1 32  ? -15.07800 -5.00700  -29.91600 1.000 31.27564 ? 32  THR A CG2 1 
ATOM   246  N N   . GLY A 1 33  ? -13.52700 -0.77900  -30.37600 1.000 31.58068 ? 33  GLY A N   1 
ATOM   247  C CA  . GLY A 1 33  ? -13.66700 0.66500   -30.37100 1.000 30.19585 ? 33  GLY A CA  1 
ATOM   248  C C   . GLY A 1 33  ? -14.74000 1.20900   -29.45500 1.000 29.01547 ? 33  GLY A C   1 
ATOM   249  O O   . GLY A 1 33  ? -14.82800 2.42600   -29.29000 1.000 32.74571 ? 33  GLY A O   1 
ATOM   250  N N   . THR A 1 34  ? -15.56900 0.35400   -28.87100 1.000 32.76406 ? 34  THR A N   1 
ATOM   251  C CA  . THR A 1 34  ? -16.56900 0.80700   -27.90900 1.000 31.71410 ? 34  THR A CA  1 
ATOM   252  C C   . THR A 1 34  ? -15.89200 1.52100   -26.74300 1.000 34.65706 ? 34  THR A C   1 
ATOM   253  O O   . THR A 1 34  ? -14.83600 1.09100   -26.27500 1.000 32.67026 ? 34  THR A O   1 
ATOM   254  C CB  . THR A 1 34  ? -17.37700 -0.39500  -27.40000 1.000 32.43812 ? 34  THR A CB  1 
ATOM   255  O OG1 . THR A 1 34  ? -18.03100 -1.03400  -28.50500 1.000 35.33660 ? 34  THR A OG1 1 
ATOM   256  C CG2 . THR A 1 34  ? -18.41900 0.03200   -26.39500 1.000 31.02465 ? 34  THR A CG2 1 
ATOM   257  N N   . GLN A 1 35  ? -16.49100 2.62700   -26.27500 1.000 33.52277 ? 35  GLN A N   1 
ATOM   258  C CA  . GLN A 1 35  ? -15.89800 3.34900   -25.15300 1.000 29.59102 ? 35  GLN A CA  1 
ATOM   259  C C   . GLN A 1 35  ? -15.79600 2.45900   -23.92300 1.000 31.13515 ? 35  GLN A C   1 
ATOM   260  O O   . GLN A 1 35  ? -16.59800 1.54900   -23.70400 1.000 29.18507 ? 35  GLN A O   1 
ATOM   261  C CB  . GLN A 1 35  ? -16.68500 4.61300   -24.80500 1.000 31.20817 ? 35  GLN A CB  1 
ATOM   262  C CG  . GLN A 1 35  ? -16.71300 5.66500   -25.89200 1.000 31.51588 ? 35  GLN A CG  1 
ATOM   263  C CD  . GLN A 1 35  ? -17.89100 5.47600   -26.81300 1.000 29.63038 ? 35  GLN A CD  1 
ATOM   264  O OE1 . GLN A 1 35  ? -18.32200 4.34800   -27.05300 1.000 29.89993 ? 35  GLN A OE1 1 
ATOM   265  N NE2 . GLN A 1 35  ? -18.41600 6.58000   -27.34400 1.000 32.17809 ? 35  GLN A NE2 1 
ATOM   266  N N   . HIS A 1 36  ? -14.77800 2.74000   -23.11900 1.000 30.54091 ? 36  HIS A N   1 
ATOM   267  C CA  . HIS A 1 36  ? -14.55700 1.99500   -21.89400 1.000 30.92616 ? 36  HIS A CA  1 
ATOM   268  C C   . HIS A 1 36  ? -15.83500 1.89500   -21.08200 1.000 31.18578 ? 36  HIS A C   1 
ATOM   269  O O   . HIS A 1 36  ? -16.25400 0.80000   -20.68900 1.000 30.59907 ? 36  HIS A O   1 
ATOM   270  C CB  . HIS A 1 36  ? -13.44300 2.68900   -21.10400 1.000 33.88013 ? 36  HIS A CB  1 
ATOM   271  C CG  . HIS A 1 36  ? -12.11800 2.00700   -21.22400 1.000 34.83719 ? 36  HIS A CG  1 
ATOM   272  N ND1 . HIS A 1 36  ? -11.65100 1.11700   -20.28300 1.000 35.60001 ? 36  HIS A ND1 1 
ATOM   273  C CD2 . HIS A 1 36  ? -11.21400 2.00200   -22.23000 1.000 34.37751 ? 36  HIS A CD2 1 
ATOM   274  C CE1 . HIS A 1 36  ? -10.49400 0.63000   -20.67900 1.000 33.04091 ? 36  HIS A CE1 1 
ATOM   275  N NE2 . HIS A 1 36  ? -10.20800 1.14400   -21.86200 1.000 40.04938 ? 36  HIS A NE2 1 
ATOM   276  N N   . PHE A 1 37  ? -16.49800 3.03400   -20.86300 1.000 28.81228 ? 37  PHE A N   1 
ATOM   277  C CA  . PHE A 1 37  ? -17.60400 3.07600   -19.91400 1.000 29.61947 ? 37  PHE A CA  1 
ATOM   278  C C   . PHE A 1 37  ? -18.81100 2.26800   -20.35800 1.000 30.54134 ? 37  PHE A C   1 
ATOM   279  O O   . PHE A 1 37  ? -19.72100 2.07900   -19.54000 1.000 30.29987 ? 37  PHE A O   1 
ATOM   280  C CB  . PHE A 1 37  ? -18.05300 4.51800   -19.64500 1.000 31.34019 ? 37  PHE A CB  1 
ATOM   281  C CG  . PHE A 1 37  ? -18.15100 5.38300   -20.88700 1.000 33.17255 ? 37  PHE A CG  1 
ATOM   282  C CD1 . PHE A 1 37  ? -19.22100 5.24800   -21.76200 1.000 30.40419 ? 37  PHE A CD1 1 
ATOM   283  C CD2 . PHE A 1 37  ? -17.18500 6.34700   -21.16400 1.000 33.27697 ? 37  PHE A CD2 1 
ATOM   284  C CE1 . PHE A 1 37  ? -19.31900 6.05100   -22.88500 1.000 31.12000 ? 37  PHE A CE1 1 
ATOM   285  C CE2 . PHE A 1 37  ? -17.28600 7.15700   -22.28900 1.000 33.75570 ? 37  PHE A CE2 1 
ATOM   286  C CZ  . PHE A 1 37  ? -18.34700 7.00700   -23.14200 1.000 29.63444 ? 37  PHE A CZ  1 
ATOM   287  N N   . LEU A 1 38  ? -18.85100 1.79800   -21.61100 1.000 25.68802 ? 38  LEU A N   1 
ATOM   288  C CA  . LEU A 1 38  ? -19.95200 0.95600   -22.05900 1.000 28.18629 ? 38  LEU A CA  1 
ATOM   289  C C   . LEU A 1 38  ? -19.71600 -0.52400  -21.79000 1.000 27.24737 ? 38  LEU A C   1 
ATOM   290  O O   . LEU A 1 38  ? -20.60400 -1.33100  -22.08700 1.000 27.14421 ? 38  LEU A O   1 
ATOM   291  C CB  . LEU A 1 38  ? -20.23100 1.15300   -23.55300 1.000 24.98654 ? 38  LEU A CB  1 
ATOM   292  C CG  . LEU A 1 38  ? -20.80000 2.51600   -23.93300 1.000 25.58194 ? 38  LEU A CG  1 
ATOM   293  C CD1 . LEU A 1 38  ? -20.75800 2.72000   -25.44800 1.000 29.97425 ? 38  LEU A CD1 1 
ATOM   294  C CD2 . LEU A 1 38  ? -22.18000 2.74600   -23.36500 1.000 22.80957 ? 38  LEU A CD2 1 
ATOM   295  N N   . ALA A 1 39  ? -18.55500 -0.89900  -21.23800 1.000 26.49891 ? 39  ALA A N   1 
ATOM   296  C CA  . ALA A 1 39  ? -18.18600 -2.30000  -21.01700 1.000 27.82033 ? 39  ALA A CA  1 
ATOM   297  C C   . ALA A 1 39  ? -18.32900 -2.63500  -19.53900 1.000 30.06740 ? 39  ALA A C   1 
ATOM   298  O O   . ALA A 1 39  ? -17.57400 -2.12400  -18.69700 1.000 27.41608 ? 39  ALA A O   1 
ATOM   299  C CB  . ALA A 1 39  ? -16.75800 -2.57700  -21.47800 1.000 26.51526 ? 39  ALA A CB  1 
ATOM   300  N N   . GLN A 1 40  ? -19.27600 -3.50300  -19.22100 1.000 26.99103 ? 40  GLN A N   1 
ATOM   301  C CA  . GLN A 1 40  ? -19.48900 -3.92000  -17.84700 1.000 25.84409 ? 40  GLN A CA  1 
ATOM   302  C C   . GLN A 1 40  ? -18.88500 -5.30200  -17.63100 1.000 27.09172 ? 40  GLN A C   1 
ATOM   303  O O   . GLN A 1 40  ? -19.08200 -6.20700  -18.45200 1.000 26.93537 ? 40  GLN A O   1 
ATOM   304  C CB  . GLN A 1 40  ? -20.98400 -3.92700  -17.50500 1.000 24.09424 ? 40  GLN A CB  1 
ATOM   305  C CG  . GLN A 1 40  ? -21.27000 -4.57400  -16.13300 1.000 22.67223 ? 40  GLN A CG  1 
ATOM   306  C CD  . GLN A 1 40  ? -22.75000 -4.61900  -15.79100 1.000 26.34801 ? 40  GLN A CD  1 
ATOM   307  O OE1 . GLN A 1 40  ? -23.19500 -5.47300  -15.01600 1.000 29.25277 ? 40  GLN A OE1 1 
ATOM   308  N NE2 . GLN A 1 40  ? -23.52100 -3.69500  -16.36400 1.000 21.97402 ? 40  GLN A NE2 1 
ATOM   309  N N   . VAL A 1 41  ? -18.14400 -5.45800  -16.53800 1.000 26.56996 ? 41  VAL A N   1 
ATOM   310  C CA  . VAL A 1 41  ? -17.65900 -6.75600  -16.07800 1.000 23.79657 ? 41  VAL A CA  1 
ATOM   311  C C   . VAL A 1 41  ? -18.34200 -7.03600  -14.75200 1.000 22.78100 ? 41  VAL A C   1 
ATOM   312  O O   . VAL A 1 41  ? -18.30100 -6.20000  -13.83900 1.000 26.70774 ? 41  VAL A O   1 
ATOM   313  C CB  . VAL A 1 41  ? -16.12500 -6.78600  -15.93800 1.000 24.96838 ? 41  VAL A CB  1 
ATOM   314  C CG1 . VAL A 1 41  ? -15.68800 -8.07600  -15.28500 1.000 27.08166 ? 41  VAL A CG1 1 
ATOM   315  C CG2 . VAL A 1 41  ? -15.45500 -6.62900  -17.29200 1.000 18.60158 ? 41  VAL A CG2 1 
ATOM   316  N N   . ASN A 1 42  ? -18.99100 -8.19900  -14.65300 1.000 27.98448 ? 42  ASN A N   1 
ATOM   317  C CA  . ASN A 1 42  ? -19.87300 -8.51900  -13.53000 1.000 25.83884 ? 42  ASN A CA  1 
ATOM   318  C C   . ASN A 1 42  ? -19.45200 -9.87900  -12.98900 1.000 22.93787 ? 42  ASN A C   1 
ATOM   319  O O   . ASN A 1 42  ? -19.74800 -10.91000 -13.59100 1.000 23.26006 ? 42  ASN A O   1 
ATOM   320  C CB  . ASN A 1 42  ? -21.34500 -8.49100  -13.95600 1.000 30.38883 ? 42  ASN A CB  1 
ATOM   321  C CG  . ASN A 1 42  ? -22.31600 -8.41000  -12.75900 1.000 28.94773 ? 42  ASN A CG  1 
ATOM   322  O OD1 . ASN A 1 42  ? -22.21500 -9.18200  -11.82000 1.000 29.20952 ? 42  ASN A OD1 1 
ATOM   323  N ND2 . ASN A 1 42  ? -23.24200 -7.44500  -12.79600 1.000 27.00175 ? 42  ASN A ND2 1 
ATOM   324  N N   . PHE A 1 43  ? -18.73500 -9.87500  -11.86100 1.000 27.77177 ? 43  PHE A N   1 
ATOM   325  C CA  . PHE A 1 43  ? -18.20000 -11.10300 -11.27900 1.000 25.86373 ? 43  PHE A CA  1 
ATOM   326  C C   . PHE A 1 43  ? -19.30200 -11.83200 -10.52300 1.000 29.35688 ? 43  PHE A C   1 
ATOM   327  O O   . PHE A 1 43  ? -19.94700 -11.25400 -9.63000  1.000 24.79972 ? 43  PHE A O   1 
ATOM   328  C CB  . PHE A 1 43  ? -17.01000 -10.80700 -10.35300 1.000 21.23379 ? 43  PHE A CB  1 
ATOM   329  C CG  . PHE A 1 43  ? -15.74400 -10.46700 -11.09200 1.000 25.67766 ? 43  PHE A CG  1 
ATOM   330  C CD1 . PHE A 1 43  ? -14.92500 -11.47500 -11.60400 1.000 23.32292 ? 43  PHE A CD1 1 
ATOM   331  C CD2 . PHE A 1 43  ? -15.38200 -9.14100  -11.30300 1.000 25.13219 ? 43  PHE A CD2 1 
ATOM   332  C CE1 . PHE A 1 43  ? -13.77500 -11.16600 -12.30100 1.000 22.00294 ? 43  PHE A CE1 1 
ATOM   333  C CE2 . PHE A 1 43  ? -14.23000 -8.82500  -12.02100 1.000 28.10865 ? 43  PHE A CE2 1 
ATOM   334  C CZ  . PHE A 1 43  ? -13.42600 -9.84000  -12.51000 1.000 24.26376 ? 43  PHE A CZ  1 
ATOM   335  N N   . GLN A 1 44  ? -19.50800 -13.10500 -10.87500 1.000 25.61831 ? 44  GLN A N   1 
ATOM   336  C CA  . GLN A 1 44  ? -20.41300 -13.99100 -10.15400 1.000 25.19774 ? 44  GLN A CA  1 
ATOM   337  C C   . GLN A 1 44  ? -19.55700 -15.04800 -9.46300  1.000 28.19476 ? 44  GLN A C   1 
ATOM   338  O O   . GLN A 1 44  ? -18.91700 -15.87300 -10.12600 1.000 30.74588 ? 44  GLN A O   1 
ATOM   339  C CB  . GLN A 1 44  ? -21.43000 -14.60200 -11.10600 1.000 23.55450 ? 44  GLN A CB  1 
ATOM   340  C CG  . GLN A 1 44  ? -22.18000 -13.53700 -11.88800 1.000 25.69360 ? 44  GLN A CG  1 
ATOM   341  C CD  . GLN A 1 44  ? -23.24800 -12.83500 -11.06600 1.000 25.53022 ? 44  GLN A CD  1 
ATOM   342  O OE1 . GLN A 1 44  ? -24.14700 -13.48100 -10.51100 1.000 31.43211 ? 44  GLN A OE1 1 
ATOM   343  N NE2 . GLN A 1 44  ? -23.13200 -11.50200 -10.94600 1.000 22.86923 ? 44  GLN A NE2 1 
ATOM   344  N N   . GLU A 1 45  ? -19.51600 -14.98900 -8.13700  1.000 29.17818 ? 45  GLU A N   1 
ATOM   345  C CA  . GLU A 1 45  ? -18.74500 -15.90900 -7.31800  1.000 24.70963 ? 45  GLU A CA  1 
ATOM   346  C C   . GLU A 1 45  ? -19.67400 -16.95400 -6.71900  1.000 28.73381 ? 45  GLU A C   1 
ATOM   347  O O   . GLU A 1 45  ? -20.79200 -16.64000 -6.30000  1.000 29.53703 ? 45  GLU A O   1 
ATOM   348  C CB  . GLU A 1 45  ? -18.02200 -15.16800 -6.19400  1.000 31.34818 ? 45  GLU A CB  1 
ATOM   349  C CG  . GLU A 1 45  ? -17.02200 -14.14100 -6.67000  1.000 33.15337 ? 45  GLU A CG  1 
ATOM   350  C CD  . GLU A 1 45  ? -16.53200 -13.24400 -5.54400  1.000 35.79106 ? 45  GLU A CD  1 
ATOM   351  O OE1 . GLU A 1 45  ? -17.36700 -12.55200 -4.91100  1.000 36.92480 ? 45  GLU A OE1 1 
ATOM   352  O OE2 . GLU A 1 45  ? -15.31200 -13.21600 -5.30100  1.000 38.60822 ? 45  GLU A OE2 1 
ATOM   353  N N   . GLN A 1 46  ? -19.20200 -18.19400 -6.68800  1.000 29.93049 ? 46  GLN A N   1 
ATOM   354  C CA  . GLN A 1 46  ? -19.86800 -19.31700 -6.05700  1.000 29.96238 ? 46  GLN A CA  1 
ATOM   355  C C   . GLN A 1 46  ? -18.82000 -20.08700 -5.25700  1.000 35.64099 ? 46  GLN A C   1 
ATOM   356  O O   . GLN A 1 46  ? -17.62600 -20.01600 -5.57600  1.000 31.28106 ? 46  GLN A O   1 
ATOM   357  C CB  . GLN A 1 46  ? -20.52400 -20.24000 -7.09500  1.000 27.24105 ? 46  GLN A CB  1 
ATOM   358  C CG  . GLN A 1 46  ? -21.74100 -19.62300 -7.79200  1.000 27.97837 ? 46  GLN A CG  1 
ATOM   359  C CD  . GLN A 1 46  ? -22.94100 -19.52300 -6.85200  1.000 29.55430 ? 46  GLN A CD  1 
ATOM   360  O OE1 . GLN A 1 46  ? -23.14400 -20.38900 -6.00600  1.000 29.53955 ? 46  GLN A OE1 1 
ATOM   361  N NE2 . GLN A 1 46  ? -23.72900 -18.45900 -6.99100  1.000 26.80814 ? 46  GLN A NE2 1 
ATOM   362  N N   . PRO A 1 47  ? -19.23400 -20.82400 -4.22400  1.000 32.40034 ? 47  PRO A N   1 
ATOM   363  C CA  . PRO A 1 47  ? -18.26300 -21.66200 -3.50100  1.000 32.75837 ? 47  PRO A CA  1 
ATOM   364  C C   . PRO A 1 47  ? -17.54600 -22.62400 -4.43600  1.000 33.08685 ? 47  PRO A C   1 
ATOM   365  O O   . PRO A 1 47  ? -18.10400 -23.09500 -5.43100  1.000 32.47860 ? 47  PRO A O   1 
ATOM   366  C CB  . PRO A 1 47  ? -19.13000 -22.40800 -2.47800  1.000 33.48411 ? 47  PRO A CB  1 
ATOM   367  C CG  . PRO A 1 47  ? -20.55400 -22.20600 -2.92500  1.000 34.26838 ? 47  PRO A CG  1 
ATOM   368  C CD  . PRO A 1 47  ? -20.57000 -20.88100 -3.61000  1.000 29.69286 ? 47  PRO A CD  1 
ATOM   369  N N   . ALA A 1 48  ? -16.28100 -22.89300 -4.12000  1.000 33.10203 ? 48  ALA A N   1 
ATOM   370  C CA  . ALA A 1 48  ? -15.52600 -23.85500 -4.90500  1.000 28.66461 ? 48  ALA A CA  1 
ATOM   371  C C   . ALA A 1 48  ? -16.14100 -25.23200 -4.73600  1.000 26.56215 ? 48  ALA A C   1 
ATOM   372  O O   . ALA A 1 48  ? -16.55500 -25.60800 -3.63900  1.000 30.70725 ? 48  ALA A O   1 
ATOM   373  C CB  . ALA A 1 48  ? -14.05500 -23.87100 -4.48000  1.000 34.93807 ? 48  ALA A CB  1 
ATOM   374  N N   . GLY A 1 49  ? -16.22400 -25.97400 -5.83800  1.000 26.96018 ? 49  GLY A N   1 
ATOM   375  C CA  . GLY A 1 49  ? -16.91100 -27.24000 -5.86600  1.000 30.47383 ? 49  GLY A CA  1 
ATOM   376  C C   . GLY A 1 49  ? -18.26000 -27.19500 -6.55500  1.000 35.57419 ? 49  GLY A C   1 
ATOM   377  O O   . GLY A 1 49  ? -18.87800 -28.26000 -6.73500  1.000 35.98001 ? 49  GLY A O   1 
ATOM   378  N N   . ASN A 1 50  ? -18.73500 -26.00600 -6.94700  1.000 28.13717 ? 50  ASN A N   1 
ATOM   379  C CA  . ASN A 1 50  ? -19.96900 -25.84600 -7.70100  1.000 30.77050 ? 50  ASN A CA  1 
ATOM   380  C C   . ASN A 1 50  ? -19.77100 -26.00300 -9.20600  1.000 32.98742 ? 50  ASN A C   1 
ATOM   381  O O   . ASN A 1 50  ? -20.75900 -25.94100 -9.94700  1.000 33.65353 ? 50  ASN A O   1 
ATOM   382  C CB  . ASN A 1 50  ? -20.60000 -24.47800 -7.40800  1.000 33.08453 ? 50  ASN A CB  1 
ATOM   383  C CG  . ASN A 1 50  ? -21.55500 -24.49800 -6.20900  1.000 31.32170 ? 50  ASN A CG  1 
ATOM   384  O OD1 . ASN A 1 50  ? -21.49500 -25.37400 -5.35900  1.000 31.97684 ? 50  ASN A OD1 1 
ATOM   385  N ND2 . ASN A 1 50  ? -22.43900 -23.50200 -6.14300  1.000 36.55087 ? 50  ASN A ND2 1 
ATOM   386  N N   . VAL A 1 51  ? -18.54100 -26.22400 -9.67200  1.000 30.40880 ? 51  VAL A N   1 
ATOM   387  C CA  . VAL A 1 51  ? -18.23700 -26.43100 -11.08600 1.000 29.21292 ? 51  VAL A CA  1 
ATOM   388  C C   . VAL A 1 51  ? -17.91500 -27.90800 -11.30300 1.000 31.82827 ? 51  VAL A C   1 
ATOM   389  O O   . VAL A 1 51  ? -17.05500 -28.46900 -10.61200 1.000 37.11577 ? 51  VAL A O   1 
ATOM   390  C CB  . VAL A 1 51  ? -17.06700 -25.53100 -11.54000 1.000 28.88991 ? 51  VAL A CB  1 
ATOM   391  C CG1 . VAL A 1 51  ? -16.71500 -25.76700 -13.00300 1.000 30.95519 ? 51  VAL A CG1 1 
ATOM   392  C CG2 . VAL A 1 51  ? -17.40700 -24.07800 -11.30800 1.000 28.41416 ? 51  VAL A CG2 1 
ATOM   393  N N   . PHE A 1 52  ? -18.58700 -28.53700 -12.27000 1.000 31.96479 ? 52  PHE A N   1 
ATOM   394  C CA  . PHE A 1 52  ? -18.34300 -29.93500 -12.61900 1.000 30.84881 ? 52  PHE A CA  1 
ATOM   395  C C   . PHE A 1 52  ? -17.95100 -30.01300 -14.08800 1.000 35.47143 ? 52  PHE A C   1 
ATOM   396  O O   . PHE A 1 52  ? -18.66900 -29.49800 -14.95600 1.000 31.42888 ? 52  PHE A O   1 
ATOM   397  C CB  . PHE A 1 52  ? -19.56900 -30.80500 -12.32800 1.000 27.67959 ? 52  PHE A CB  1 
ATOM   398  C CG  . PHE A 1 52  ? -19.90200 -30.91000 -10.85100 1.000 30.24763 ? 52  PHE A CG  1 
ATOM   399  C CD1 . PHE A 1 52  ? -20.56700 -29.87800 -10.19500 1.000 27.82302 ? 52  PHE A CD1 1 
ATOM   400  C CD2 . PHE A 1 52  ? -19.55300 -32.03800 -10.11800 1.000 35.74102 ? 52  PHE A CD2 1 
ATOM   401  C CE1 . PHE A 1 52  ? -20.88400 -29.97000 -8.82100  1.000 31.39629 ? 52  PHE A CE1 1 
ATOM   402  C CE2 . PHE A 1 52  ? -19.86400 -32.13500 -8.73900  1.000 35.96217 ? 52  PHE A CE2 1 
ATOM   403  C CZ  . PHE A 1 52  ? -20.51900 -31.10100 -8.09900  1.000 29.89135 ? 52  PHE A CZ  1 
ATOM   404  N N   . LEU A 1 53  ? -16.79800 -30.62800 -14.35500 1.000 36.61923 ? 53  LEU A N   1 
ATOM   405  C CA  . LEU A 1 53  ? -16.30300 -30.87400 -15.70500 1.000 36.10487 ? 53  LEU A CA  1 
ATOM   406  C C   . LEU A 1 53  ? -16.34700 -32.37200 -15.96200 1.000 39.74588 ? 53  LEU A C   1 
ATOM   407  O O   . LEU A 1 53  ? -15.77400 -33.14700 -15.19000 1.000 37.93037 ? 53  LEU A O   1 
ATOM   408  C CB  . LEU A 1 53  ? -14.87100 -30.36000 -15.85700 1.000 38.29743 ? 53  LEU A CB  1 
ATOM   409  C CG  . LEU A 1 53  ? -14.73500 -28.83900 -15.80400 1.000 39.48944 ? 53  LEU A CG  1 
ATOM   410  C CD1 . LEU A 1 53  ? -13.35500 -28.42200 -16.21500 1.000 40.94789 ? 53  LEU A CD1 1 
ATOM   411  C CD2 . LEU A 1 53  ? -15.75600 -28.20100 -16.70900 1.000 35.46055 ? 53  LEU A CD2 1 
ATOM   412  N N   . GLY A 1 54  ? -17.04600 -32.78300 -17.02000 1.000 35.04597 ? 54  GLY A N   1 
ATOM   413  C CA  . GLY A 1 54  ? -17.24300 -34.19900 -17.28600 1.000 36.02863 ? 54  GLY A CA  1 
ATOM   414  C C   . GLY A 1 54  ? -17.87000 -34.92600 -16.11000 1.000 36.81301 ? 54  GLY A C   1 
ATOM   415  O O   . GLY A 1 54  ? -17.73500 -36.14500 -15.94800 1.000 39.07185 ? 54  GLY A O   1 
ATOM   416  N N   . GLY A 1 55  ? -18.59000 -34.17400 -15.28800 1.000 35.87703 ? 55  GLY A N   1 
ATOM   417  C CA  . GLY A 1 55  ? -19.10300 -34.69900 -14.04700 1.000 39.07115 ? 55  GLY A CA  1 
ATOM   418  C C   . GLY A 1 55  ? -18.07600 -34.83600 -12.95000 1.000 40.65462 ? 55  GLY A C   1 
ATOM   419  O O   . GLY A 1 55  ? -18.30800 -35.57800 -11.99500 1.000 42.19074 ? 55  GLY A O   1 
ATOM   420  N N   . VAL A 1 56  ? -16.93700 -34.16300 -13.06200 1.000 39.95120 ? 56  VAL A N   1 
ATOM   421  C CA  . VAL A 1 56  ? -15.89600 -34.20600 -12.04200 1.000 38.40767 ? 56  VAL A CA  1 
ATOM   422  C C   . VAL A 1 56  ? -15.89000 -32.84500 -11.36900 1.000 34.14039 ? 56  VAL A C   1 
ATOM   423  O O   . VAL A 1 56  ? -15.71900 -31.82000 -12.03700 1.000 37.16220 ? 56  VAL A O   1 
ATOM   424  C CB  . VAL A 1 56  ? -14.51400 -34.53300 -12.63200 1.000 41.29582 ? 56  VAL A CB  1 
ATOM   425  C CG1 . VAL A 1 56  ? -13.42700 -34.38300 -11.55900 1.000 43.72052 ? 56  VAL A CG1 1 
ATOM   426  C CG2 . VAL A 1 56  ? -14.49800 -35.92700 -13.27500 1.000 41.59357 ? 56  VAL A CG2 1 
ATOM   427  N N   . GLN A 1 57  ? -16.10700 -32.83100 -10.06200 1.000 37.07800 ? 57  GLN A N   1 
ATOM   428  C CA  . GLN A 1 57  ? -16.11900 -31.58100 -9.31500  1.000 39.13166 ? 57  GLN A CA  1 
ATOM   429  C C   . GLN A 1 57  ? -14.74900 -30.91400 -9.40600  1.000 37.72752 ? 57  GLN A C   1 
ATOM   430  O O   . GLN A 1 57  ? -13.71600 -31.58000 -9.35300  1.000 37.16747 ? 57  GLN A O   1 
ATOM   431  C CB  . GLN A 1 57  ? -16.49500 -31.86800 -7.86300  1.000 32.12726 ? 57  GLN A CB  1 
ATOM   432  C CG  . GLN A 1 57  ? -16.61200 -30.66100 -6.95100  1.000 38.48394 ? 57  GLN A CG  1 
ATOM   433  C CD  . GLN A 1 57  ? -17.13400 -31.04900 -5.57300  1.000 35.64580 ? 57  GLN A CD  1 
ATOM   434  O OE1 . GLN A 1 57  ? -16.74200 -32.06500 -5.02600  1.000 41.11610 ? 57  GLN A OE1 1 
ATOM   435  N NE2 . GLN A 1 57  ? -18.01100 -30.23700 -5.01300  1.000 38.87605 ? 57  GLN A NE2 1 
ATOM   436  N N   . GLN A 1 58  ? -14.73400 -29.59600 -9.56600  1.000 35.15572 ? 58  GLN A N   1 
ATOM   437  C CA  . GLN A 1 58  ? -13.48100 -28.86200 -9.68500  1.000 34.68915 ? 58  GLN A CA  1 
ATOM   438  C C   . GLN A 1 58  ? -13.12700 -28.14900 -8.38500  1.000 36.22661 ? 58  GLN A C   1 
ATOM   439  O O   . GLN A 1 58  ? -13.97600 -27.91200 -7.52000  1.000 34.46696 ? 58  GLN A O   1 
ATOM   440  C CB  . GLN A 1 58  ? -13.55800 -27.83500 -10.81000 1.000 35.80666 ? 58  GLN A CB  1 
ATOM   441  C CG  . GLN A 1 58  ? -13.97100 -28.39900 -12.13000 1.000 35.88736 ? 58  GLN A CG  1 
ATOM   442  C CD  . GLN A 1 58  ? -12.92000 -29.29700 -12.69800 1.000 38.39399 ? 58  GLN A CD  1 
ATOM   443  O OE1 . GLN A 1 58  ? -11.81700 -28.84900 -13.02000 1.000 41.13867 ? 58  GLN A OE1 1 
ATOM   444  N NE2 . GLN A 1 58  ? -13.25600 -30.57600 -12.85100 1.000 38.22002 ? 58  GLN A NE2 1 
ATOM   445  N N   . GLY A 1 59  ? -11.85300 -27.78400 -8.26900  1.000 30.55882 ? 59  GLY A N   1 
ATOM   446  C CA  . GLY A 1 59  ? -11.43500 -26.85900 -7.23800  1.000 36.65892 ? 59  GLY A CA  1 
ATOM   447  C C   . GLY A 1 59  ? -11.99400 -25.47200 -7.50500  1.000 43.63177 ? 59  GLY A C   1 
ATOM   448  O O   . GLY A 1 59  ? -13.10900 -25.32800 -8.01700  1.000 46.53610 ? 59  GLY A O   1 
ATOM   449  N N   . GLY A 1 60  ? -11.24400 -24.43100 -7.17800  1.000 43.47988 ? 60  GLY A N   1 
ATOM   450  C CA  . GLY A 1 60  ? -11.71100 -23.11000 -7.54600  1.000 38.78452 ? 60  GLY A CA  1 
ATOM   451  C C   . GLY A 1 60  ? -10.90700 -22.46100 -8.65400  1.000 35.64515 ? 60  GLY A C   1 
ATOM   452  O O   . GLY A 1 60  ? -10.69600 -21.25000 -8.62100  1.000 36.24701 ? 60  GLY A O   1 
ATOM   453  N N   . ASP A 1 61  ? -10.44900 -23.23000 -9.64200  1.000 36.18844 ? 61  ASP A N   1 
ATOM   454  C CA  . ASP A 1 61  ? -9.57900  -22.66600 -10.67400 1.000 39.78293 ? 61  ASP A CA  1 
ATOM   455  C C   . ASP A 1 61  ? -10.30000 -22.25600 -11.95000 1.000 35.00332 ? 61  ASP A C   1 
ATOM   456  O O   . ASP A 1 61  ? -9.76200  -21.43700 -12.70600 1.000 36.65843 ? 61  ASP A O   1 
ATOM   457  C CB  . ASP A 1 61  ? -8.47300  -23.65200 -11.06500 1.000 39.01403 ? 61  ASP A CB  1 
ATOM   458  C CG  . ASP A 1 61  ? -7.25800  -23.54600 -10.17700 1.000 45.51818 ? 61  ASP A CG  1 
ATOM   459  O OD1 . ASP A 1 61  ? -6.90000  -22.40700 -9.79200  1.000 45.90555 ? 61  ASP A OD1 1 
ATOM   460  O OD2 . ASP A 1 61  ? -6.65400  -24.60300 -9.88800  1.000 45.85698 ? 61  ASP A OD2 1 
ATOM   461  N N   . THR A 1 62  ? -11.46700 -22.81600 -12.23500 1.000 32.53448 ? 62  THR A N   1 
ATOM   462  C CA  . THR A 1 62  ? -12.09600 -22.58100 -13.52700 1.000 32.56616 ? 62  THR A CA  1 
ATOM   463  C C   . THR A 1 62  ? -12.70200 -21.18400 -13.59200 1.000 31.96672 ? 62  THR A C   1 
ATOM   464  O O   . THR A 1 62  ? -13.32300 -20.70400 -12.63600 1.000 31.67588 ? 62  THR A O   1 
ATOM   465  C CB  . THR A 1 62  ? -13.16300 -23.64500 -13.80900 1.000 35.61245 ? 62  THR A CB  1 
ATOM   466  O OG1 . THR A 1 62  ? -12.72000 -24.91100 -13.29200 1.000 39.73097 ? 62  THR A OG1 1 
ATOM   467  C CG2 . THR A 1 62  ? -13.40500 -23.77900 -15.32500 1.000 32.83261 ? 62  THR A CG2 1 
ATOM   468  N N   . ILE A 1 63  ? -12.49400 -20.52600 -14.72900 1.000 35.17929 ? 63  ILE A N   1 
ATOM   469  C CA  . ILE A 1 63  ? -13.13200 -19.25800 -15.04600 1.000 31.48526 ? 63  ILE A CA  1 
ATOM   470  C C   . ILE A 1 63  ? -13.96500 -19.45600 -16.29600 1.000 30.87440 ? 63  ILE A C   1 
ATOM   471  O O   . ILE A 1 63  ? -13.47700 -20.00900 -17.28800 1.000 27.39165 ? 63  ILE A O   1 
ATOM   472  C CB  . ILE A 1 63  ? -12.11000 -18.12400 -15.24500 1.000 29.90415 ? 63  ILE A CB  1 
ATOM   473  C CG1 . ILE A 1 63  ? -11.09300 -18.11200 -14.10200 1.000 37.81493 ? 63  ILE A CG1 1 
ATOM   474  C CG2 . ILE A 1 63  ? -12.79700 -16.77500 -15.40700 1.000 29.96176 ? 63  ILE A CG2 1 
ATOM   475  C CD1 . ILE A 1 63  ? -9.82700  -17.35400 -14.41500 1.000 39.57064 ? 63  ILE A CD1 1 
ATOM   476  N N   . PHE A 1 64  ? -15.21700 -19.01000 -16.24100 1.000 26.56027 ? 64  PHE A N   1 
ATOM   477  C CA  . PHE A 1 64  ? -16.09300 -18.96800 -17.40100 1.000 25.82366 ? 64  PHE A CA  1 
ATOM   478  C C   . PHE A 1 64  ? -16.48900 -17.51700 -17.63300 1.000 23.43174 ? 64  PHE A C   1 
ATOM   479  O O   . PHE A 1 64  ? -17.11800 -16.88900 -16.77600 1.000 21.86798 ? 64  PHE A O   1 
ATOM   480  C CB  . PHE A 1 64  ? -17.32500 -19.85700 -17.21200 1.000 26.47627 ? 64  PHE A CB  1 
ATOM   481  C CG  . PHE A 1 64  ? -18.32500 -19.75200 -18.33200 1.000 28.21484 ? 64  PHE A CG  1 
ATOM   482  C CD1 . PHE A 1 64  ? -17.90100 -19.74900 -19.65300 1.000 24.87766 ? 64  PHE A CD1 1 
ATOM   483  C CD2 . PHE A 1 64  ? -19.67400 -19.61800 -18.06200 1.000 23.01024 ? 64  PHE A CD2 1 
ATOM   484  C CE1 . PHE A 1 64  ? -18.79500 -19.64400 -20.68900 1.000 23.68937 ? 64  PHE A CE1 1 
ATOM   485  C CE2 . PHE A 1 64  ? -20.58400 -19.50800 -19.09000 1.000 27.92528 ? 64  PHE A CE2 1 
ATOM   486  C CZ  . PHE A 1 64  ? -20.14300 -19.52100 -20.41900 1.000 25.16099 ? 64  PHE A CZ  1 
ATOM   487  N N   . VAL A 1 65  ? -16.08400 -16.98800 -18.77200 1.000 24.63920 ? 65  VAL A N   1 
ATOM   488  C CA  . VAL A 1 65  ? -16.49100 -15.67600 -19.24500 1.000 24.09110 ? 65  VAL A CA  1 
ATOM   489  C C   . VAL A 1 65  ? -17.59300 -15.88200 -20.27700 1.000 28.92725 ? 65  VAL A C   1 
ATOM   490  O O   . VAL A 1 65  ? -17.38500 -16.57100 -21.28700 1.000 25.04874 ? 65  VAL A O   1 
ATOM   491  C CB  . VAL A 1 65  ? -15.30300 -14.91700 -19.85900 1.000 27.22379 ? 65  VAL A CB  1 
ATOM   492  C CG1 . VAL A 1 65  ? -15.75800 -13.55700 -20.42400 1.000 25.36349 ? 65  VAL A CG1 1 
ATOM   493  C CG2 . VAL A 1 65  ? -14.15600 -14.76700 -18.82300 1.000 23.73498 ? 65  VAL A CG2 1 
ATOM   494  N N   . HIS A 1 66  ? -18.76200 -15.29100 -20.01700 1.000 24.12177 ? 66  HIS A N   1 
ATOM   495  C CA  . HIS A 1 66  ? -19.87600 -15.24400 -20.95500 1.000 22.30700 ? 66  HIS A CA  1 
ATOM   496  C C   . HIS A 1 66  ? -20.04200 -13.80500 -21.43700 1.000 22.35809 ? 66  HIS A C   1 
ATOM   497  O O   . HIS A 1 66  ? -20.56300 -12.95000 -20.71400 1.000 24.04383 ? 66  HIS A O   1 
ATOM   498  C CB  . HIS A 1 66  ? -21.15700 -15.74800 -20.30400 1.000 22.49333 ? 66  HIS A CB  1 
ATOM   499  C CG  . HIS A 1 66  ? -22.28200 -15.92900 -21.26900 1.000 25.09933 ? 66  HIS A CG  1 
ATOM   500  N ND1 . HIS A 1 66  ? -23.59800 -16.00900 -20.87000 1.000 22.70805 ? 66  HIS A ND1 1 
ATOM   501  C CD2 . HIS A 1 66  ? -22.29000 -16.04600 -22.62000 1.000 24.49842 ? 66  HIS A CD2 1 
ATOM   502  C CE1 . HIS A 1 66  ? -24.36900 -16.16900 -21.92900 1.000 24.35510 ? 66  HIS A CE1 1 
ATOM   503  N NE2 . HIS A 1 66  ? -23.60100 -16.19500 -23.00400 1.000 26.08323 ? 66  HIS A NE2 1 
ATOM   504  N N   . GLY A 1 67  ? -19.61100 -13.53300 -22.66100 1.000 20.82038 ? 67  GLY A N   1 
ATOM   505  C CA  . GLY A 1 67  ? -19.74600 -12.19900 -23.22600 1.000 23.26271 ? 67  GLY A CA  1 
ATOM   506  C C   . GLY A 1 67  ? -21.09200 -12.03500 -23.90500 1.000 21.11640 ? 67  GLY A C   1 
ATOM   507  O O   . GLY A 1 67  ? -21.51000 -12.89300 -24.68800 1.000 21.59569 ? 67  GLY A O   1 
ATOM   508  N N   . LEU A 1 68  ? -21.77100 -10.92600 -23.59400 1.000 22.52555 ? 68  LEU A N   1 
ATOM   509  C CA  . LEU A 1 68  ? -23.06900 -10.56500 -24.16700 1.000 22.26737 ? 68  LEU A CA  1 
ATOM   510  C C   . LEU A 1 68  ? -22.86600 -9.31100  -25.01300 1.000 24.15422 ? 68  LEU A C   1 
ATOM   511  O O   . LEU A 1 68  ? -22.74300 -8.20400  -24.46800 1.000 23.30768 ? 68  LEU A O   1 
ATOM   512  C CB  . LEU A 1 68  ? -24.09100 -10.33100 -23.06000 1.000 20.52728 ? 68  LEU A CB  1 
ATOM   513  C CG  . LEU A 1 68  ? -24.34600 -11.52100 -22.14100 1.000 24.04231 ? 68  LEU A CG  1 
ATOM   514  C CD1 . LEU A 1 68  ? -25.28900 -11.15700 -20.98100 1.000 24.42627 ? 68  LEU A CD1 1 
ATOM   515  C CD2 . LEU A 1 68  ? -24.86100 -12.71400 -22.95100 1.000 22.40996 ? 68  LEU A CD2 1 
ATOM   516  N N   . HIS A 1 69  ? -22.84800 -9.49000  -26.33900 1.000 23.67514 ? 69  HIS A N   1 
ATOM   517  C CA  . HIS A 1 69  ? -22.47400 -8.46100  -27.30300 1.000 26.71682 ? 69  HIS A CA  1 
ATOM   518  C C   . HIS A 1 69  ? -23.66400 -7.99800  -28.13300 1.000 20.62977 ? 69  HIS A C   1 
ATOM   519  O O   . HIS A 1 69  ? -24.67300 -8.69600  -28.27700 1.000 23.91638 ? 69  HIS A O   1 
ATOM   520  C CB  . HIS A 1 69  ? -21.40000 -8.95200  -28.29700 1.000 21.35776 ? 69  HIS A CB  1 
ATOM   521  C CG  . HIS A 1 69  ? -20.06500 -9.23100  -27.69100 1.000 21.10262 ? 69  HIS A CG  1 
ATOM   522  N ND1 . HIS A 1 69  ? -19.05600 -9.85400  -28.38900 1.000 28.36421 ? 69  HIS A ND1 1 
ATOM   523  C CD2 . HIS A 1 69  ? -19.56300 -8.96900  -26.46200 1.000 26.65390 ? 69  HIS A CD2 1 
ATOM   524  C CE1 . HIS A 1 69  ? -17.99300 -9.98100  -27.61000 1.000 30.64899 ? 69  HIS A CE1 1 
ATOM   525  N NE2 . HIS A 1 69  ? -18.27300 -9.44800  -26.43700 1.000 27.26119 ? 69  HIS A NE2 1 
ATOM   526  N N   . ARG A 1 70  ? -23.49800 -6.82700  -28.73000 1.000 20.23595 ? 70  ARG A N   1 
ATOM   527  C CA  . ARG A 1 70  ? -24.31700 -6.43700  -29.86100 1.000 22.16952 ? 70  ARG A CA  1 
ATOM   528  C C   . ARG A 1 70  ? -23.88000 -7.22200  -31.08300 1.000 24.33245 ? 70  ARG A C   1 
ATOM   529  O O   . ARG A 1 70  ? -22.69300 -7.50700  -31.25700 1.000 25.78185 ? 70  ARG A O   1 
ATOM   530  C CB  . ARG A 1 70  ? -24.19400 -4.94900  -30.15700 1.000 24.16940 ? 70  ARG A CB  1 
ATOM   531  C CG  . ARG A 1 70  ? -24.71000 -4.02500  -29.08400 1.000 21.84209 ? 70  ARG A CG  1 
ATOM   532  C CD  . ARG A 1 70  ? -24.27300 -2.59900  -29.34600 1.000 23.02697 ? 70  ARG A CD  1 
ATOM   533  N NE  . ARG A 1 70  ? -22.89900 -2.35200  -28.90600 1.000 26.31712 ? 70  ARG A NE  1 
ATOM   534  C CZ  . ARG A 1 70  ? -22.13800 -1.32900  -29.26800 1.000 27.05440 ? 70  ARG A CZ  1 
ATOM   535  N NH1 . ARG A 1 70  ? -22.56300 -0.42500  -30.12700 1.000 27.19553 ? 70  ARG A NH1 1 
ATOM   536  N NH2 . ARG A 1 70  ? -20.92000 -1.21400  -28.74400 1.000 29.35245 ? 70  ARG A NH2 1 
ATOM   537  N N   . GLU A 1 71  ? -24.85600 -7.58500  -31.91400 1.000 26.68862 ? 71  GLU A N   1 
ATOM   538  C CA  . GLU A 1 71  ? -24.63300 -8.17200  -33.22900 1.000 23.84514 ? 71  GLU A CA  1 
ATOM   539  C C   . GLU A 1 71  ? -23.95300 -7.16900  -34.15400 1.000 21.83346 ? 71  GLU A C   1 
ATOM   540  O O   . GLU A 1 71  ? -24.05500 -5.95600  -33.96600 1.000 23.86528 ? 71  GLU A O   1 
ATOM   541  C CB  . GLU A 1 71  ? -25.97000 -8.58000  -33.86300 1.000 23.30289 ? 71  GLU A CB  1 
ATOM   542  C CG  . GLU A 1 71  ? -26.71200 -9.64600  -33.12500 1.000 26.14543 ? 71  GLU A CG  1 
ATOM   543  C CD  . GLU A 1 71  ? -28.08100 -9.93000  -33.73700 1.000 34.19960 ? 71  GLU A CD  1 
ATOM   544  O OE1 . GLU A 1 71  ? -28.54100 -9.16700  -34.62600 1.000 34.14659 ? 71  GLU A OE1 1 
ATOM   545  O OE2 . GLU A 1 71  ? -28.70300 -10.92300 -33.31700 1.000 33.48777 ? 71  GLU A OE2 1 
ATOM   546  N N   . GLY A 1 72  ? -23.28500 -7.69300  -35.18400 1.000 19.72326 ? 72  GLY A N   1 
ATOM   547  C CA  . GLY A 1 72  ? -22.72300 -6.87700  -36.24500 1.000 19.30753 ? 72  GLY A CA  1 
ATOM   548  C C   . GLY A 1 72  ? -21.22600 -7.02900  -36.46100 1.000 25.46924 ? 72  GLY A C   1 
ATOM   549  O O   . GLY A 1 72  ? -20.69200 -6.42100  -37.39900 1.000 25.76913 ? 72  GLY A O   1 
ATOM   550  N N   . ARG A 1 73  ? -20.49400 -7.80900  -35.67400 1.000 24.13016 ? 73  ARG A N   1 
ATOM   551  C CA  . ARG A 1 73  ? -19.05700 -7.92000  -35.87900 1.000 23.02135 ? 73  ARG A CA  1 
ATOM   552  C C   . ARG A 1 73  ? -18.70900 -9.21200  -36.61100 1.000 23.11826 ? 73  ARG A C   1 
ATOM   553  O O   . ARG A 1 73  ? -19.45900 -10.18900 -36.60300 1.000 19.03481 ? 73  ARG A O   1 
ATOM   554  C CB  . ARG A 1 73  ? -18.30900 -7.84200  -34.54300 1.000 25.76314 ? 73  ARG A CB  1 
ATOM   555  C CG  . ARG A 1 73  ? -18.70000 -6.60300  -33.74100 1.000 25.28002 ? 73  ARG A CG  1 
ATOM   556  C CD  . ARG A 1 73  ? -17.76400 -6.30800  -32.59800 1.000 29.13004 ? 73  ARG A CD  1 
ATOM   557  N NE  . ARG A 1 73  ? -17.88800 -4.91700  -32.15400 1.000 35.22357 ? 73  ARG A NE  1 
ATOM   558  C CZ  . ARG A 1 73  ? -18.63100 -4.52900  -31.12600 1.000 35.35156 ? 73  ARG A CZ  1 
ATOM   559  N NH1 . ARG A 1 73  ? -19.42800 -5.37500  -30.50500 1.000 36.09434 ? 73  ARG A NH1 1 
ATOM   560  N NH2 . ARG A 1 73  ? -18.55900 -3.26900  -30.70900 1.000 33.86657 ? 73  ARG A NH2 1 
ATOM   561  N N   . SER A 1 74  ? -17.55900 -9.20000  -37.26100 1.000 25.58795 ? 74  SER A N   1 
ATOM   562  C CA  . SER A 1 74  ? -17.15400 -10.35200 -38.04000 1.000 27.35393 ? 74  SER A CA  1 
ATOM   563  C C   . SER A 1 74  ? -16.72200 -11.48600 -37.12300 1.000 26.28607 ? 74  SER A C   1 
ATOM   564  O O   . SER A 1 74  ? -16.27900 -11.26600 -35.99100 1.000 23.86515 ? 74  SER A O   1 
ATOM   565  C CB  . SER A 1 74  ? -16.02200 -9.96700  -38.97200 1.000 22.49826 ? 74  SER A CB  1 
ATOM   566  O OG  . SER A 1 74  ? -14.84900 -9.79800  -38.21500 1.000 27.43363 ? 74  SER A OG  1 
ATOM   567  N N   . ALA A 1 75  ? -16.86600 -12.71600 -37.62800 1.000 22.43431 ? 75  ALA A N   1 
ATOM   568  C CA  . ALA A 1 75  ? -16.38500 -13.88100 -36.89500 1.000 24.08029 ? 75  ALA A CA  1 
ATOM   569  C C   . ALA A 1 75  ? -14.89700 -13.76500 -36.57900 1.000 25.24632 ? 75  ALA A C   1 
ATOM   570  O O   . ALA A 1 75  ? -14.44200 -14.22300 -35.52000 1.000 20.68297 ? 75  ALA A O   1 
ATOM   571  C CB  . ALA A 1 75  ? -16.67800 -15.14800 -37.70300 1.000 23.24061 ? 75  ALA A CB  1 
ATOM   572  N N   . ASP A 1 76  ? -14.13400 -13.12400 -37.46700 1.000 26.37733 ? 76  ASP A N   1 
ATOM   573  C CA  . ASP A 1 76  ? -12.69600 -12.97900 -37.25300 1.000 27.64540 ? 76  ASP A CA  1 
ATOM   574  C C   . ASP A 1 76  ? -12.39800 -11.99800 -36.12200 1.000 29.90795 ? 76  ASP A C   1 
ATOM   575  O O   . ASP A 1 76  ? -11.50500 -12.24000 -35.29400 1.000 24.86658 ? 76  ASP A O   1 
ATOM   576  C CB  . ASP A 1 76  ? -12.04300 -12.54700 -38.57000 1.000 29.54349 ? 76  ASP A CB  1 
ATOM   577  C CG  . ASP A 1 76  ? -10.69800 -11.89700 -38.37800 1.000 35.65433 ? 76  ASP A CG  1 
ATOM   578  O OD1 . ASP A 1 76  ? -9.83100  -12.48200 -37.70100 1.000 36.96910 ? 76  ASP A OD1 1 
ATOM   579  O OD2 . ASP A 1 76  ? -10.51700 -10.77800 -38.89700 1.000 48.09187 ? 76  ASP A OD2 1 
ATOM   580  N N   . LEU A 1 77  ? -13.13800 -10.88400 -36.06400 1.000 25.96519 ? 77  LEU A N   1 
ATOM   581  C CA  . LEU A 1 77  ? -12.96900 -9.96100  -34.95000 1.000 25.96844 ? 77  LEU A CA  1 
ATOM   582  C C   . LEU A 1 77  ? -13.29000 -10.64900 -33.63000 1.000 27.48645 ? 77  LEU A C   1 
ATOM   583  O O   . LEU A 1 77  ? -12.53900 -10.52100 -32.65200 1.000 27.73795 ? 77  LEU A O   1 
ATOM   584  C CB  . LEU A 1 77  ? -13.84800 -8.72400  -35.14500 1.000 24.68071 ? 77  LEU A CB  1 
ATOM   585  C CG  . LEU A 1 77  ? -13.64400 -7.59500  -34.13000 1.000 30.07288 ? 77  LEU A CG  1 
ATOM   586  C CD1 . LEU A 1 77  ? -14.35300 -7.77200  -32.76000 1.000 27.92992 ? 77  LEU A CD1 1 
ATOM   587  C CD2 . LEU A 1 77  ? -12.15300 -7.42400  -33.94200 1.000 31.51698 ? 77  LEU A CD2 1 
ATOM   588  N N   . LYS A 1 78  ? -14.39700 -11.39000 -33.58500 1.000 26.23751 ? 78  LYS A N   1 
ATOM   589  C CA  . LYS A 1 78  ? -14.78000 -12.06300 -32.34800 1.000 22.95744 ? 78  LYS A CA  1 
ATOM   590  C C   . LYS A 1 78  ? -13.77100 -13.14600 -31.96800 1.000 24.82760 ? 78  LYS A C   1 
ATOM   591  O O   . LYS A 1 78  ? -13.49100 -13.35000 -30.77700 1.000 25.38565 ? 78  LYS A O   1 
ATOM   592  C CB  . LYS A 1 78  ? -16.18200 -12.64300 -32.49400 1.000 23.04767 ? 78  LYS A CB  1 
ATOM   593  C CG  . LYS A 1 78  ? -17.24400 -11.56500 -32.63100 1.000 30.61734 ? 78  LYS A CG  1 
ATOM   594  C CD  . LYS A 1 78  ? -18.62300 -12.17500 -32.81900 1.000 29.56079 ? 78  LYS A CD  1 
ATOM   595  C CE  . LYS A 1 78  ? -18.77400 -12.77100 -34.19500 1.000 21.43284 ? 78  LYS A CE  1 
ATOM   596  N NZ  . LYS A 1 78  ? -20.18300 -13.24400 -34.32500 1.000 21.57158 ? 78  LYS A NZ  1 
ATOM   597  N N   . GLY A 1 79  ? -13.20600 -13.83700 -32.96300 1.000 25.93756 ? 79  GLY A N   1 
ATOM   598  C CA  . GLY A 1 79  ? -12.13900 -14.78000 -32.68200 1.000 21.55142 ? 79  GLY A CA  1 
ATOM   599  C C   . GLY A 1 79  ? -10.92700 -14.10500 -32.06800 1.000 25.00964 ? 79  GLY A C   1 
ATOM   600  O O   . GLY A 1 79  ? -10.31000 -14.63700 -31.13600 1.000 22.46052 ? 79  GLY A O   1 
ATOM   601  N N   . GLN A 1 80  ? -10.58200 -12.91000 -32.56400 1.000 23.82253 ? 80  GLN A N   1 
ATOM   602  C CA  . GLN A 1 80  ? -9.47900  -12.14500 -31.98100 1.000 30.49399 ? 80  GLN A CA  1 
ATOM   603  C C   . GLN A 1 80  ? -9.84000  -11.61300 -30.59900 1.000 27.82330 ? 80  GLN A C   1 
ATOM   604  O O   . GLN A 1 80  ? -8.97000  -11.50200 -29.72300 1.000 29.65372 ? 80  GLN A O   1 
ATOM   605  C CB  . GLN A 1 80  ? -9.09200  -10.98100 -32.89800 1.000 27.41945 ? 80  GLN A CB  1 
ATOM   606  C CG  . GLN A 1 80  ? -8.63000  -11.37600 -34.29400 1.000 31.44266 ? 80  GLN A CG  1 
ATOM   607  C CD  . GLN A 1 80  ? -8.20200  -10.15800 -35.07900 1.000 38.00429 ? 80  GLN A CD  1 
ATOM   608  O OE1 . GLN A 1 80  ? -7.52100  -9.28600  -34.54200 1.000 36.52201 ? 80  GLN A OE1 1 
ATOM   609  N NE2 . GLN A 1 80  ? -8.61100  -10.07800 -36.34600 1.000 39.21651 ? 80  GLN A NE2 1 
ATOM   610  N N   . LEU A 1 81  ? -11.11100 -11.27100 -30.38700 1.000 21.99312 ? 81  LEU A N   1 
ATOM   611  C CA  . LEU A 1 81  ? -11.51400 -10.79400 -29.07100 1.000 24.52396 ? 81  LEU A CA  1 
ATOM   612  C C   . LEU A 1 81  ? -11.52500 -11.93200 -28.05400 1.000 26.93774 ? 81  LEU A C   1 
ATOM   613  O O   . LEU A 1 81  ? -11.03500 -11.77400 -26.92500 1.000 27.31049 ? 81  LEU A O   1 
ATOM   614  C CB  . LEU A 1 81  ? -12.88100 -10.12200 -29.16300 1.000 27.57090 ? 81  LEU A CB  1 
ATOM   615  C CG  . LEU A 1 81  ? -13.41600 -9.40000  -27.92400 1.000 26.53591 ? 81  LEU A CG  1 
ATOM   616  C CD1 . LEU A 1 81  ? -12.31000 -8.78400  -27.09700 1.000 24.11280 ? 81  LEU A CD1 1 
ATOM   617  C CD2 . LEU A 1 81  ? -14.39400 -8.33100  -28.36600 1.000 32.95369 ? 81  LEU A CD2 1 
ATOM   618  N N   . ALA A 1 82  ? -12.06400 -13.08900 -28.43500 1.000 24.00126 ? 82  ALA A N   1 
ATOM   619  C CA  . ALA A 1 82  ? -12.08500 -14.22100 -27.51400 1.000 22.02191 ? 82  ALA A CA  1 
ATOM   620  C C   . ALA A 1 82  ? -10.67000 -14.63800 -27.13500 1.000 27.65248 ? 82  ALA A C   1 
ATOM   621  O O   . ALA A 1 82  ? -10.36000 -14.82200 -25.95100 1.000 27.85495 ? 82  ALA A O   1 
ATOM   622  C CB  . ALA A 1 82  ? -12.84400 -15.39100 -28.13100 1.000 18.37803 ? 82  ALA A CB  1 
ATOM   623  N N   . GLN A 1 83  ? -9.78800  -14.77100 -28.13300 1.000 24.37797 ? 83  GLN A N   1 
ATOM   624  C CA  . GLN A 1 83  ? -8.40900  -15.17500 -27.86900 1.000 27.33618 ? 83  GLN A CA  1 
ATOM   625  C C   . GLN A 1 83  ? -7.69200  -14.18300 -26.96000 1.000 28.30839 ? 83  GLN A C   1 
ATOM   626  O O   . GLN A 1 83  ? -6.90300  -14.58100 -26.09400 1.000 28.47251 ? 83  GLN A O   1 
ATOM   627  C CB  . GLN A 1 83  ? -7.63200  -15.31900 -29.18100 1.000 23.19114 ? 83  GLN A CB  1 
ATOM   628  C CG  . GLN A 1 83  ? -6.21600  -15.86000 -28.98200 1.000 32.29586 ? 83  GLN A CG  1 
ATOM   629  C CD  . GLN A 1 83  ? -6.22100  -17.30300 -28.48100 1.000 32.32788 ? 83  GLN A CD  1 
ATOM   630  O OE1 . GLN A 1 83  ? -6.72900  -18.20100 -29.15300 1.000 35.25678 ? 83  GLN A OE1 1 
ATOM   631  N NE2 . GLN A 1 83  ? -5.67800  -17.52100 -27.28800 1.000 31.44103 ? 83  GLN A NE2 1 
ATOM   632  N N   . ARG A 1 84  ? -7.91500  -12.88500 -27.16500 1.000 28.43980 ? 84  ARG A N   1 
ATOM   633  C CA  . ARG A 1 84  ? -7.18300  -11.91900 -26.36600 1.000 28.17296 ? 84  ARG A CA  1 
ATOM   634  C C   . ARG A 1 84  ? -7.71800  -11.87600 -24.93700 1.000 29.05426 ? 84  ARG A C   1 
ATOM   635  O O   . ARG A 1 84  ? -6.94200  -11.68700 -23.99200 1.000 29.04143 ? 84  ARG A O   1 
ATOM   636  C CB  . ARG A 1 84  ? -7.22500  -10.54400 -27.03000 1.000 24.75682 ? 84  ARG A CB  1 
ATOM   637  C CG  . ARG A 1 84  ? -6.58000  -9.47300  -26.18100 1.000 34.00651 ? 84  ARG A CG  1 
ATOM   638  C CD  . ARG A 1 84  ? -6.58500  -8.07000  -26.79000 1.000 39.31023 ? 84  ARG A CD  1 
ATOM   639  N NE  . ARG A 1 84  ? -6.08400  -7.13000  -25.79000 1.000 45.28617 ? 84  ARG A NE  1 
ATOM   640  C CZ  . ARG A 1 84  ? -5.89400  -5.82700  -25.97000 1.000 50.52239 ? 84  ARG A CZ  1 
ATOM   641  N NH1 . ARG A 1 84  ? -6.12000  -5.24400  -27.14000 1.000 47.89751 ? 84  ARG A NH1 1 
ATOM   642  N NH2 . ARG A 1 84  ? -5.47900  -5.08600  -24.94400 1.000 46.36632 ? 84  ARG A NH2 1 
ATOM   643  N N   . ILE A 1 85  ? -9.02200  -12.09300 -24.75200 1.000 27.59270 ? 85  ILE A N   1 
ATOM   644  C CA  . ILE A 1 85  ? -9.56400  -12.21600 -23.39800 1.000 28.37026 ? 85  ILE A CA  1 
ATOM   645  C C   . ILE A 1 85  ? -8.92700  -13.41200 -22.68800 1.000 31.50011 ? 85  ILE A C   1 
ATOM   646  O O   . ILE A 1 85  ? -8.48400  -13.31500 -21.53300 1.000 31.69556 ? 85  ILE A O   1 
ATOM   647  C CB  . ILE A 1 85  ? -11.10400 -12.32600 -23.43000 1.000 26.69925 ? 85  ILE A CB  1 
ATOM   648  C CG1 . ILE A 1 85  ? -11.76200 -10.95800 -23.48100 1.000 27.17930 ? 85  ILE A CG1 1 
ATOM   649  C CG2 . ILE A 1 85  ? -11.65100 -13.05600 -22.19200 1.000 29.21678 ? 85  ILE A CG2 1 
ATOM   650  C CD1 . ILE A 1 85  ? -13.18400 -11.04700 -23.93000 1.000 26.97612 ? 85  ILE A CD1 1 
ATOM   651  N N   . VAL A 1 86  ? -8.85800  -14.55800 -23.37300 1.000 28.88861 ? 86  VAL A N   1 
ATOM   652  C CA  . VAL A 1 86  ? -8.23900  -15.74100 -22.77500 1.000 29.70097 ? 86  VAL A CA  1 
ATOM   653  C C   . VAL A 1 86  ? -6.79000  -15.44500 -22.38800 1.000 32.54841 ? 86  VAL A C   1 
ATOM   654  O O   . VAL A 1 86  ? -6.35000  -15.75300 -21.27200 1.000 29.67527 ? 86  VAL A O   1 
ATOM   655  C CB  . VAL A 1 86  ? -8.33900  -16.93800 -23.74100 1.000 31.55732 ? 86  VAL A CB  1 
ATOM   656  C CG1 . VAL A 1 86  ? -7.51500  -18.11900 -23.23700 1.000 32.62043 ? 86  VAL A CG1 1 
ATOM   657  C CG2 . VAL A 1 86  ? -9.79900  -17.33800 -23.95600 1.000 29.04146 ? 86  VAL A CG2 1 
ATOM   658  N N   . ASP A 1 87  ? -6.02900  -14.83800 -23.30300 1.000 31.52622 ? 87  ASP A N   1 
ATOM   659  C CA  . ASP A 1 87  ? -4.64900  -14.46800 -22.99800 1.000 30.18866 ? 87  ASP A CA  1 
ATOM   660  C C   . ASP A 1 87  ? -4.58000  -13.50100 -21.82400 1.000 29.22207 ? 87  ASP A C   1 
ATOM   661  O O   . ASP A 1 87  ? -3.90200  -13.76300 -20.82300 1.000 33.53990 ? 87  ASP A O   1 
ATOM   662  C CB  . ASP A 1 87  ? -3.97200  -13.83900 -24.22300 1.000 31.58330 ? 87  ASP A CB  1 
ATOM   663  C CG  . ASP A 1 87  ? -3.79000  -14.81400 -25.36800 1.000 37.21030 ? 87  ASP A CG  1 
ATOM   664  O OD1 . ASP A 1 87  ? -3.78500  -16.03800 -25.09500 1.000 32.47272 ? 87  ASP A OD1 1 
ATOM   665  O OD2 . ASP A 1 87  ? -3.64100  -14.35000 -26.52600 1.000 39.13208 ? 87  ASP A OD2 1 
ATOM   666  N N   . ASP A 1 88  ? -5.26300  -12.36100 -21.93600 1.000 26.74843 ? 88  ASP A N   1 
ATOM   667  C CA  . ASP A 1 88  ? -5.07200  -11.30800 -20.94800 1.000 32.32321 ? 88  ASP A CA  1 
ATOM   668  C C   . ASP A 1 88  ? -5.59500  -11.72500 -19.58300 1.000 33.68790 ? 88  ASP A C   1 
ATOM   669  O O   . ASP A 1 88  ? -5.00000  -11.37500 -18.55400 1.000 34.57484 ? 88  ASP A O   1 
ATOM   670  C CB  . ASP A 1 88  ? -5.73100  -10.00600 -21.41500 1.000 29.12802 ? 88  ASP A CB  1 
ATOM   671  C CG  . ASP A 1 88  ? -4.97200  -9.35100  -22.56300 1.000 36.43362 ? 88  ASP A CG  1 
ATOM   672  O OD1 . ASP A 1 88  ? -3.94900  -9.94400  -22.99700 1.000 33.38559 ? 88  ASP A OD1 1 
ATOM   673  O OD2 . ASP A 1 88  ? -5.36500  -8.24300  -23.00500 1.000 37.66827 ? 88  ASP A OD2 1 
ATOM   674  N N   . VAL A 1 89  ? -6.70400  -12.47200 -19.54800 1.000 31.48549 ? 89  VAL A N   1 
ATOM   675  C CA  . VAL A 1 89  ? -7.25300  -12.89300 -18.25900 1.000 28.62811 ? 89  VAL A CA  1 
ATOM   676  C C   . VAL A 1 89  ? -6.31000  -13.89000 -17.60100 1.000 32.34201 ? 89  VAL A C   1 
ATOM   677  O O   . VAL A 1 89  ? -6.16200  -13.91300 -16.36500 1.000 29.95149 ? 89  VAL A O   1 
ATOM   678  C CB  . VAL A 1 89  ? -8.67200  -13.46600 -18.45300 1.000 25.92000 ? 89  VAL A CB  1 
ATOM   679  C CG1 . VAL A 1 89  ? -9.10100  -14.30200 -17.26400 1.000 26.83662 ? 89  VAL A CG1 1 
ATOM   680  C CG2 . VAL A 1 89  ? -9.69400  -12.32200 -18.69400 1.000 24.74830 ? 89  VAL A CG2 1 
ATOM   681  N N   . SER A 1 90  ? -5.64500  -14.71000 -18.42200 1.000 29.34754 ? 90  SER A N   1 
ATOM   682  C CA  . SER A 1 90  ? -4.65700  -15.66400 -17.92800 1.000 32.83256 ? 90  SER A CA  1 
ATOM   683  C C   . SER A 1 90  ? -3.53300  -14.95900 -17.17100 1.000 32.70374 ? 90  SER A C   1 
ATOM   684  O O   . SER A 1 90  ? -3.11800  -15.40300 -16.09300 1.000 36.36391 ? 90  SER A O   1 
ATOM   685  C CB  . SER A 1 90  ? -4.08700  -16.46200 -19.10400 1.000 28.61464 ? 90  SER A CB  1 
ATOM   686  O OG  . SER A 1 90  ? -3.22700  -17.48000 -18.65200 1.000 35.33664 ? 90  SER A OG  1 
ATOM   687  N N   . VAL A 1 91  ? -3.02300  -13.86100 -17.72400 1.000 30.85407 ? 91  VAL A N   1 
ATOM   688  C CA  . VAL A 1 91  ? -1.96800  -13.11500 -17.05100 1.000 33.58305 ? 91  VAL A CA  1 
ATOM   689  C C   . VAL A 1 91  ? -2.51000  -12.41400 -15.80800 1.000 38.85524 ? 91  VAL A C   1 
ATOM   690  O O   . VAL A 1 91  ? -1.88800  -12.44700 -14.74100 1.000 38.46874 ? 91  VAL A O   1 
ATOM   691  C CB  . VAL A 1 91  ? -1.33500  -12.11800 -18.03300 1.000 33.32060 ? 91  VAL A CB  1 
ATOM   692  C CG1 . VAL A 1 91  ? -0.44800  -11.11000 -17.29300 1.000 29.78437 ? 91  VAL A CG1 1 
ATOM   693  C CG2 . VAL A 1 91  ? -0.57300  -12.86700 -19.10400 1.000 33.13632 ? 91  VAL A CG2 1 
ATOM   694  N N   . ALA A 1 92  ? -3.69200  -11.79300 -15.92100 1.000 40.44845 ? 92  ALA A N   1 
ATOM   695  C CA  . ALA A 1 92  ? -4.21700  -10.93000 -14.86500 1.000 34.40082 ? 92  ALA A CA  1 
ATOM   696  C C   . ALA A 1 92  ? -4.70700  -11.71800 -13.66300 1.000 36.49630 ? 92  ALA A C   1 
ATOM   697  O O   . ALA A 1 92  ? -4.60200  -11.23900 -12.52500 1.000 35.70399 ? 92  ALA A O   1 
ATOM   698  C CB  . ALA A 1 92  ? -5.35200  -10.05900 -15.41600 1.000 34.69595 ? 92  ALA A CB  1 
ATOM   699  N N   . ALA A 1 93  ? -5.26300  -12.89900 -13.88300 1.000 33.02457 ? 93  ALA A N   1 
ATOM   700  C CA  . ALA A 1 93  ? -5.66100  -13.74400 -12.77400 1.000 35.27973 ? 93  ALA A CA  1 
ATOM   701  C C   . ALA A 1 93  ? -4.57700  -14.74100 -12.39000 1.000 37.19209 ? 93  ALA A C   1 
ATOM   702  O O   . ALA A 1 93  ? -4.76200  -15.49400 -11.43000 1.000 41.67332 ? 93  ALA A O   1 
ATOM   703  C CB  . ALA A 1 93  ? -6.96100  -14.48500 -13.10600 1.000 33.40930 ? 93  ALA A CB  1 
ATOM   704  N N   . GLU A 1 94  ? -3.45400  -14.75800 -13.10400 1.000 36.75090 ? 94  GLU A N   1 
ATOM   705  C CA  . GLU A 1 94  ? -2.40600  -15.75000 -12.88200 1.000 39.26424 ? 94  GLU A CA  1 
ATOM   706  C C   . GLU A 1 94  ? -2.99800  -17.15900 -12.86400 1.000 42.25424 ? 94  GLU A C   1 
ATOM   707  O O   . GLU A 1 94  ? -2.93300  -17.87600 -11.86500 1.000 44.61692 ? 94  GLU A O   1 
ATOM   708  C CB  . GLU A 1 94  ? -1.63900  -15.46300 -11.59000 1.000 41.52122 ? 94  GLU A CB  1 
ATOM   709  C CG  . GLU A 1 94  ? -1.01900  -14.07800 -11.53400 1.000 48.09739 ? 94  GLU A CG  1 
ATOM   710  C CD  . GLU A 1 94  ? -0.28300  -13.80700 -10.22900 1.000 61.25460 ? 94  GLU A CD  1 
ATOM   711  O OE1 . GLU A 1 94  ? 0.54900   -14.65200 -9.81900  1.000 67.13797 ? 94  GLU A OE1 1 
ATOM   712  O OE2 . GLU A 1 94  ? -0.53500  -12.74500 -9.61600  1.000 70.01725 ? 94  GLU A OE2 1 
ATOM   713  N N   . ILE A 1 95  ? -3.61400  -17.53700 -13.98600 1.000 39.47231 ? 95  ILE A N   1 
ATOM   714  C CA  . ILE A 1 95  ? -4.28300  -18.82900 -14.10200 1.000 35.16671 ? 95  ILE A CA  1 
ATOM   715  C C   . ILE A 1 95  ? -3.94700  -19.41500 -15.47100 1.000 35.07253 ? 95  ILE A C   1 
ATOM   716  O O   . ILE A 1 95  ? -3.86300  -18.68800 -16.46800 1.000 31.96187 ? 95  ILE A O   1 
ATOM   717  C CB  . ILE A 1 95  ? -5.80800  -18.67800 -13.89700 1.000 36.21880 ? 95  ILE A CB  1 
ATOM   718  C CG1 . ILE A 1 95  ? -6.48800  -20.04000 -13.80400 1.000 35.37741 ? 95  ILE A CG1 1 
ATOM   719  C CG2 . ILE A 1 95  ? -6.42200  -17.83700 -15.01500 1.000 38.69556 ? 95  ILE A CG2 1 
ATOM   720  C CD1 . ILE A 1 95  ? -5.74500  -21.02800 -12.91100 1.000 46.70885 ? 95  ILE A CD1 1 
ATOM   721  N N   . ASP A 1 96  ? -3.71400  -20.72400 -15.52000 1.000 34.90118 ? 96  ASP A N   1 
ATOM   722  C CA  . ASP A 1 96  ? -3.39900  -21.35400 -16.79400 1.000 34.22589 ? 96  ASP A CA  1 
ATOM   723  C C   . ASP A 1 96  ? -4.58000  -21.25800 -17.75500 1.000 34.67246 ? 96  ASP A C   1 
ATOM   724  O O   . ASP A 1 96  ? -5.75200  -21.34700 -17.37100 1.000 31.61025 ? 96  ASP A O   1 
ATOM   725  C CB  . ASP A 1 96  ? -3.02600  -22.82200 -16.61100 1.000 38.98203 ? 96  ASP A CB  1 
ATOM   726  C CG  . ASP A 1 96  ? -1.89800  -23.25400 -17.52400 1.000 43.96023 ? 96  ASP A CG  1 
ATOM   727  O OD1 . ASP A 1 96  ? -1.30400  -22.37900 -18.19800 1.000 58.79390 ? 96  ASP A OD1 1 
ATOM   728  O OD2 . ASP A 1 96  ? -1.58400  -24.45900 -17.55300 1.000 53.93718 ? 96  ASP A OD2 1 
ATOM   729  N N   . ARG A 1 97  ? -4.25200  -21.11200 -19.03000 1.000 33.30452 ? 97  ARG A N   1 
ATOM   730  C CA  . ARG A 1 97  ? -5.27200  -20.92100 -20.04900 1.000 36.13365 ? 97  ARG A CA  1 
ATOM   731  C C   . ARG A 1 97  ? -6.22700  -22.09800 -20.13800 1.000 34.92030 ? 97  ARG A C   1 
ATOM   732  O O   . ARG A 1 97  ? -7.39400  -21.90900 -20.49100 1.000 34.28161 ? 97  ARG A O   1 
ATOM   733  C CB  . ARG A 1 97  ? -4.56300  -20.67100 -21.36800 1.000 32.71218 ? 97  ARG A CB  1 
ATOM   734  C CG  . ARG A 1 97  ? -4.33800  -19.20400 -21.58300 1.000 34.76029 ? 97  ARG A CG  1 
ATOM   735  C CD  . ARG A 1 97  ? -4.25500  -18.87000 -23.06300 1.000 44.70567 ? 97  ARG A CD  1 
ATOM   736  N NE  . ARG A 1 97  ? -3.14800  -19.51900 -23.75900 1.000 43.21137 ? 97  ARG A NE  1 
ATOM   737  C CZ  . ARG A 1 97  ? -1.88300  -19.46400 -23.37000 1.000 42.66173 ? 97  ARG A CZ  1 
ATOM   738  N NH1 . ARG A 1 97  ? -1.51100  -18.74300 -22.32200 1.000 48.86820 ? 97  ARG A NH1 1 
ATOM   739  N NH2 . ARG A 1 97  ? -0.96400  -20.12000 -24.06800 1.000 45.14436 ? 97  ARG A NH2 1 
ATOM   740  N N   . LYS A 1 98  ? -5.77600  -23.29500 -19.77200 1.000 32.52430 ? 98  LYS A N   1 
ATOM   741  C CA  . LYS A 1 98  ? -6.63400  -24.47100 -19.82500 1.000 35.23199 ? 98  LYS A CA  1 
ATOM   742  C C   . LYS A 1 98  ? -7.83700  -24.36900 -18.88800 1.000 31.97139 ? 98  LYS A C   1 
ATOM   743  O O   . LYS A 1 98  ? -8.79100  -25.14600 -19.03200 1.000 29.09949 ? 98  LYS A O   1 
ATOM   744  C CB  . LYS A 1 98  ? -5.80000  -25.72000 -19.50400 1.000 37.02762 ? 98  LYS A CB  1 
ATOM   745  C CG  . LYS A 1 98  ? -4.69300  -26.00900 -20.52600 1.000 41.55180 ? 98  LYS A CG  1 
ATOM   746  C CD  . LYS A 1 98  ? -3.91900  -27.28500 -20.15600 1.000 45.53246 ? 98  LYS A CD  1 
ATOM   747  C CE  . LYS A 1 98  ? -2.52100  -26.95300 -19.61300 1.000 47.17306 ? 98  LYS A CE  1 
ATOM   748  N NZ  . LYS A 1 98  ? -1.54600  -26.64500 -20.71100 1.000 53.48193 ? 98  LYS A NZ  1 
ATOM   749  N N   . HIS A 1 99  ? -7.83200  -23.41300 -17.96400 1.000 30.61331 ? 99  HIS A N   1 
ATOM   750  C CA  . HIS A 1 99  ? -8.93700  -23.20200 -17.04100 1.000 32.56741 ? 99  HIS A CA  1 
ATOM   751  C C   . HIS A 1 99  ? -9.96800  -22.18500 -17.53500 1.000 32.56398 ? 99  HIS A C   1 
ATOM   752  O O   . HIS A 1 99  ? -10.97600 -21.96800 -16.85500 1.000 29.66345 ? 99  HIS A O   1 
ATOM   753  C CB  . HIS A 1 99  ? -8.38500  -22.75600 -15.68500 1.000 29.81353 ? 99  HIS A CB  1 
ATOM   754  C CG  . HIS A 1 99  ? -7.64100  -23.83200 -14.96100 1.000 35.87504 ? 99  HIS A CG  1 
ATOM   755  N ND1 . HIS A 1 99  ? -8.22600  -25.03300 -14.61400 1.000 38.54255 ? 99  HIS A ND1 1 
ATOM   756  C CD2 . HIS A 1 99  ? -6.36600  -23.88800 -14.50600 1.000 37.64874 ? 99  HIS A CD2 1 
ATOM   757  C CE1 . HIS A 1 99  ? -7.34200  -25.78200 -13.97800 1.000 40.34050 ? 99  HIS A CE1 1 
ATOM   758  N NE2 . HIS A 1 99  ? -6.20400  -25.11100 -13.90200 1.000 41.52465 ? 99  HIS A NE2 1 
ATOM   759  N N   . ILE A 1 100 ? -9.75800  -21.56900 -18.69900 1.000 32.27771 ? 100 ILE A N   1 
ATOM   760  C CA  . ILE A 1 100 ? -10.54000 -20.41100 -19.12900 1.000 27.72947 ? 100 ILE A CA  1 
ATOM   761  C C   . ILE A 1 100 ? -11.51300 -20.83000 -20.22200 1.000 27.81276 ? 100 ILE A C   1 
ATOM   762  O O   . ILE A 1 100 ? -11.10600 -21.32200 -21.28800 1.000 29.81011 ? 100 ILE A O   1 
ATOM   763  C CB  . ILE A 1 100 ? -9.63900  -19.26600 -19.60500 1.000 27.90450 ? 100 ILE A CB  1 
ATOM   764  C CG1 . ILE A 1 100 ? -8.58400  -18.99400 -18.52300 1.000 28.21615 ? 100 ILE A CG1 1 
ATOM   765  C CG2 . ILE A 1 100 ? -10.47300 -18.03100 -19.85900 1.000 30.26083 ? 100 ILE A CG2 1 
ATOM   766  C CD1 . ILE A 1 100 ? -7.64000  -17.88200 -18.81500 1.000 23.41468 ? 100 ILE A CD1 1 
ATOM   767  N N   . TRP A 1 101 ? -12.80100 -20.61800 -19.95600 1.000 28.38447 ? 101 TRP A N   1 
ATOM   768  C CA  . TRP A 1 101 ? -13.87100 -20.81200 -20.92500 1.000 25.05384 ? 101 TRP A CA  1 
ATOM   769  C C   . TRP A 1 101 ? -14.46700 -19.44900 -21.26500 1.000 29.18920 ? 101 TRP A C   1 
ATOM   770  O O   . TRP A 1 101 ? -14.77600 -18.65900 -20.36300 1.000 28.53653 ? 101 TRP A O   1 
ATOM   771  C CB  . TRP A 1 101 ? -14.95600 -21.74500 -20.37500 1.000 23.18085 ? 101 TRP A CB  1 
ATOM   772  C CG  . TRP A 1 101 ? -14.50800 -23.16200 -20.05800 1.000 25.73836 ? 101 TRP A CG  1 
ATOM   773  C CD1 . TRP A 1 101 ? -13.32600 -23.54800 -19.46500 1.000 27.21139 ? 101 TRP A CD1 1 
ATOM   774  C CD2 . TRP A 1 101 ? -15.25000 -24.37100 -20.28300 1.000 28.11666 ? 101 TRP A CD2 1 
ATOM   775  N NE1 . TRP A 1 101 ? -13.29200 -24.91600 -19.32000 1.000 26.65718 ? 101 TRP A NE1 1 
ATOM   776  C CE2 . TRP A 1 101 ? -14.45700 -25.44500 -19.80700 1.000 28.53104 ? 101 TRP A CE2 1 
ATOM   777  C CE3 . TRP A 1 101 ? -16.50900 -24.65300 -20.83100 1.000 23.94902 ? 101 TRP A CE3 1 
ATOM   778  C CZ2 . TRP A 1 101 ? -14.87500 -26.77100 -19.88200 1.000 29.83297 ? 101 TRP A CZ2 1 
ATOM   779  C CZ3 . TRP A 1 101 ? -16.92500 -25.96600 -20.89400 1.000 25.07248 ? 101 TRP A CZ3 1 
ATOM   780  C CH2 . TRP A 1 101 ? -16.11300 -27.01000 -20.43000 1.000 28.45512 ? 101 TRP A CH2 1 
ATOM   781  N N   . VAL A 1 102 ? -14.63000 -19.17500 -22.56000 1.000 23.83354 ? 102 VAL A N   1 
ATOM   782  C CA  . VAL A 1 102 ? -15.14300 -17.88900 -23.03700 1.000 28.16385 ? 102 VAL A CA  1 
ATOM   783  C C   . VAL A 1 102 ? -16.18200 -18.17400 -24.11400 1.000 26.98980 ? 102 VAL A C   1 
ATOM   784  O O   . VAL A 1 102 ? -15.86100 -18.82500 -25.11500 1.000 25.16755 ? 102 VAL A O   1 
ATOM   785  C CB  . VAL A 1 102 ? -14.02400 -16.97900 -23.59400 1.000 26.30254 ? 102 VAL A CB  1 
ATOM   786  C CG1 . VAL A 1 102 ? -14.58900 -15.71400 -24.16900 1.000 21.69587 ? 102 VAL A CG1 1 
ATOM   787  C CG2 . VAL A 1 102 ? -13.00400 -16.64100 -22.50300 1.000 27.08089 ? 102 VAL A CG2 1 
ATOM   788  N N   . PHE A 1 103 ? -17.43200 -17.74300 -23.88300 1.000 23.55386 ? 103 PHE A N   1 
ATOM   789  C CA  . PHE A 1 103 ? -18.53900 -17.81300 -24.84600 1.000 24.21195 ? 103 PHE A CA  1 
ATOM   790  C C   . PHE A 1 103 ? -19.06300 -16.40700 -25.12700 1.000 22.78040 ? 103 PHE A C   1 
ATOM   791  O O   . PHE A 1 103 ? -19.23200 -15.60000 -24.20200 1.000 24.05999 ? 103 PHE A O   1 
ATOM   792  C CB  . PHE A 1 103 ? -19.76200 -18.65300 -24.33300 1.000 24.41913 ? 103 PHE A CB  1 
ATOM   793  C CG  . PHE A 1 103 ? -19.51400 -20.15000 -24.15200 1.000 25.72436 ? 103 PHE A CG  1 
ATOM   794  C CD1 . PHE A 1 103 ? -18.31100 -20.75800 -24.52300 1.000 21.09001 ? 103 PHE A CD1 1 
ATOM   795  C CD2 . PHE A 1 103 ? -20.54600 -20.96000 -23.65700 1.000 21.45288 ? 103 PHE A CD2 1 
ATOM   796  C CE1 . PHE A 1 103 ? -18.12900 -22.13800 -24.33600 1.000 22.13672 ? 103 PHE A CE1 1 
ATOM   797  C CE2 . PHE A 1 103 ? -20.38100 -22.33800 -23.49700 1.000 19.65954 ? 103 PHE A CE2 1 
ATOM   798  C CZ  . PHE A 1 103 ? -19.16600 -22.92600 -23.83400 1.000 20.92889 ? 103 PHE A CZ  1 
ATOM   799  N N   . PHE A 1 104 ? -19.33700 -16.11200 -26.39500 1.000 21.59483 ? 104 PHE A N   1 
ATOM   800  C CA  . PHE A 1 104 ? -19.98000 -14.85700 -26.79100 1.000 22.10385 ? 104 PHE A CA  1 
ATOM   801  C C   . PHE A 1 104 ? -21.40400 -15.11300 -27.30700 1.000 24.17524 ? 104 PHE A C   1 
ATOM   802  O O   . PHE A 1 104 ? -21.60400 -15.88100 -28.25700 1.000 21.41541 ? 104 PHE A O   1 
ATOM   803  C CB  . PHE A 1 104 ? -19.19700 -14.12800 -27.88100 1.000 21.21775 ? 104 PHE A CB  1 
ATOM   804  C CG  . PHE A 1 104 ? -17.87600 -13.59500 -27.43800 1.000 21.71517 ? 104 PHE A CG  1 
ATOM   805  C CD1 . PHE A 1 104 ? -17.57000 -13.47500 -26.09800 1.000 19.87349 ? 104 PHE A CD1 1 
ATOM   806  C CD2 . PHE A 1 104 ? -16.94100 -13.19100 -28.37400 1.000 22.23696 ? 104 PHE A CD2 1 
ATOM   807  C CE1 . PHE A 1 104 ? -16.34800 -12.98700 -25.68800 1.000 21.39782 ? 104 PHE A CE1 1 
ATOM   808  C CE2 . PHE A 1 104 ? -15.69600 -12.68000 -27.97700 1.000 20.45940 ? 104 PHE A CE2 1 
ATOM   809  C CZ  . PHE A 1 104 ? -15.39900 -12.58400 -26.63500 1.000 22.73955 ? 104 PHE A CZ  1 
ATOM   810  N N   . GLY A 1 105 ? -22.38400 -14.44600 -26.70700 1.000 22.48959 ? 105 GLY A N   1 
ATOM   811  C CA  . GLY A 1 105 ? -23.74700 -14.40000 -27.23300 1.000 27.75660 ? 105 GLY A CA  1 
ATOM   812  C C   . GLY A 1 105 ? -24.03000 -13.01900 -27.79900 1.000 26.06812 ? 105 GLY A C   1 
ATOM   813  O O   . GLY A 1 105 ? -23.59400 -12.01500 -27.23300 1.000 29.81296 ? 105 GLY A O   1 
ATOM   814  N N   . GLU A 1 106 ? -24.74700 -12.96400 -28.92200 1.000 23.98676 ? 106 GLU A N   1 
ATOM   815  C CA  . GLU A 1 106 ? -25.03200 -11.69700 -29.58500 1.000 23.56413 ? 106 GLU A CA  1 
ATOM   816  C C   . GLU A 1 106 ? -26.52800 -11.42700 -29.63000 1.000 24.93699 ? 106 GLU A C   1 
ATOM   817  O O   . GLU A 1 106 ? -27.33200 -12.35000 -29.78000 1.000 24.19062 ? 106 GLU A O   1 
ATOM   818  C CB  . GLU A 1 106 ? -24.46200 -11.67400 -31.01300 1.000 23.58589 ? 106 GLU A CB  1 
ATOM   819  C CG  . GLU A 1 106 ? -23.00100 -11.99700 -31.06700 1.000 25.77102 ? 106 GLU A CG  1 
ATOM   820  C CD  . GLU A 1 106 ? -22.55500 -12.41200 -32.44200 1.000 27.10958 ? 106 GLU A CD  1 
ATOM   821  O OE1 . GLU A 1 106 ? -22.66600 -13.60700 -32.77700 1.000 24.83423 ? 106 GLU A OE1 1 
ATOM   822  O OE2 . GLU A 1 106 ? -22.06900 -11.54000 -33.18300 1.000 25.68617 ? 106 GLU A OE2 1 
ATOM   823  N N   . MET A 1 107 ? -26.89100 -10.14500 -29.53300 1.000 24.40281 ? 107 MET A N   1 
ATOM   824  C CA  . MET A 1 107 ? -28.28000 -9.70300  -29.61100 1.000 23.37600 ? 107 MET A CA  1 
ATOM   825  C C   . MET A 1 107 ? -28.33700 -8.40600  -30.41000 1.000 28.68266 ? 107 MET A C   1 
ATOM   826  O O   . MET A 1 107 ? -27.39200 -7.60300  -30.36200 1.000 27.12484 ? 107 MET A O   1 
ATOM   827  C CB  . MET A 1 107 ? -28.89100 -9.40700  -28.23900 1.000 22.56358 ? 107 MET A CB  1 
ATOM   828  C CG  . MET A 1 107 ? -29.22700 -10.59600 -27.37600 1.000 26.16077 ? 107 MET A CG  1 
ATOM   829  S SD  . MET A 1 107 ? -28.76700 -10.22200 -25.64100 1.000 34.88780 ? 107 MET A SD  1 
ATOM   830  C CE  . MET A 1 107 ? -27.07100 -9.64700  -25.73600 1.000 24.34307 ? 107 MET A CE  1 
ATOM   831  N N   . PRO A 1 108 ? -29.43500 -8.16100  -31.12600 1.000 22.90910 ? 108 PRO A N   1 
ATOM   832  C CA  . PRO A 1 108 ? -29.60700 -6.85000  -31.77700 1.000 24.70589 ? 108 PRO A CA  1 
ATOM   833  C C   . PRO A 1 108 ? -29.52700 -5.69400  -30.77600 1.000 29.06643 ? 108 PRO A C   1 
ATOM   834  O O   . PRO A 1 108 ? -30.20900 -5.68200  -29.74300 1.000 24.68359 ? 108 PRO A O   1 
ATOM   835  C CB  . PRO A 1 108 ? -31.00000 -6.94900  -32.40800 1.000 24.54749 ? 108 PRO A CB  1 
ATOM   836  C CG  . PRO A 1 108 ? -31.31200 -8.42100  -32.51600 1.000 25.21907 ? 108 PRO A CG  1 
ATOM   837  C CD  . PRO A 1 108 ? -30.56900 -9.07800  -31.35800 1.000 24.74390 ? 108 PRO A CD  1 
ATOM   838  N N   . ALA A 1 109 ? -28.69700 -4.69700  -31.10600 1.000 25.94550 ? 109 ALA A N   1 
ATOM   839  C CA  . ALA A 1 109 ? -28.57700 -3.49400  -30.27600 1.000 26.87560 ? 109 ALA A CA  1 
ATOM   840  C C   . ALA A 1 109 ? -29.92900 -2.85800  -29.94200 1.000 25.31283 ? 109 ALA A C   1 
ATOM   841  O O   . ALA A 1 109 ? -30.05200 -2.17500  -28.91600 1.000 22.06682 ? 109 ALA A O   1 
ATOM   842  C CB  . ALA A 1 109 ? -27.68600 -2.45900  -30.97600 1.000 24.88684 ? 109 ALA A CB  1 
ATOM   843  N N   . GLN A 1 110 ? -30.94400 -3.05300  -30.79900 1.000 26.11662 ? 110 GLN A N   1 
ATOM   844  C CA  . GLN A 1 110 ? -32.27400 -2.48300  -30.56900 1.000 27.08486 ? 110 GLN A CA  1 
ATOM   845  C C   . GLN A 1 110 ? -32.98000 -3.09700  -29.36600 1.000 25.00392 ? 110 GLN A C   1 
ATOM   846  O O   . GLN A 1 110 ? -33.97700 -2.53600  -28.90000 1.000 26.43241 ? 110 GLN A O   1 
ATOM   847  C CB  . GLN A 1 110 ? -33.15600 -2.64200  -31.81700 1.000 25.54779 ? 110 GLN A CB  1 
ATOM   848  C CG  . GLN A 1 110 ? -33.50900 -4.12100  -32.18900 1.000 33.75831 ? 110 GLN A CG  1 
ATOM   849  C CD  . GLN A 1 110 ? -34.70500 -4.80200  -31.42500 1.000 36.91986 ? 110 GLN A CD  1 
ATOM   850  O OE1 . GLN A 1 110 ? -35.43900 -4.18700  -30.58900 1.000 34.60248 ? 110 GLN A OE1 1 
ATOM   851  N NE2 . GLN A 1 110 ? -34.88700 -6.10100  -31.71900 1.000 23.28560 ? 110 GLN A NE2 1 
ATOM   852  N N   . GLN A 1 111 ? -32.50600 -4.23200  -28.85800 1.000 24.50057 ? 111 GLN A N   1 
ATOM   853  C CA  . GLN A 1 111 ? -33.03400 -4.80900  -27.62800 1.000 23.04960 ? 111 GLN A CA  1 
ATOM   854  C C   . GLN A 1 111 ? -31.95700 -4.84400  -26.55900 1.000 24.86775 ? 111 GLN A C   1 
ATOM   855  O O   . GLN A 1 111 ? -31.91400 -5.74800  -25.72300 1.000 22.75065 ? 111 GLN A O   1 
ATOM   856  C CB  . GLN A 1 111 ? -33.62200 -6.20500  -27.86700 1.000 26.36270 ? 111 GLN A CB  1 
ATOM   857  C CG  . GLN A 1 111 ? -32.67600 -7.25700  -28.51300 1.000 22.29121 ? 111 GLN A CG  1 
ATOM   858  C CD  . GLN A 1 111 ? -33.43700 -8.41200  -29.20600 1.000 23.87378 ? 111 GLN A CD  1 
ATOM   859  O OE1 . GLN A 1 111 ? -34.17000 -8.20400  -30.18300 1.000 24.25376 ? 111 GLN A OE1 1 
ATOM   860  N NE2 . GLN A 1 111 ? -33.26100 -9.63800  -28.69000 1.000 21.24331 ? 111 GLN A NE2 1 
ATOM   861  N N   . MET A 1 112 ? -31.08500 -3.83600  -26.54100 1.000 25.05249 ? 112 MET A N   1 
ATOM   862  C CA  . MET A 1 112 ? -30.01000 -3.79900  -25.55200 1.000 26.06425 ? 112 MET A CA  1 
ATOM   863  C C   . MET A 1 112 ? -29.95100 -2.40800  -24.92700 1.000 21.96365 ? 112 MET A C   1 
ATOM   864  O O   . MET A 1 112 ? -29.85800 -1.41000  -25.64700 1.000 20.76748 ? 112 MET A O   1 
ATOM   865  C CB  . MET A 1 112 ? -28.67100 -4.15600  -26.20400 1.000 22.92336 ? 112 MET A CB  1 
ATOM   866  C CG  . MET A 1 112 ? -28.44100 -5.63200  -26.25000 1.000 25.93072 ? 112 MET A CG  1 
ATOM   867  S SD  . MET A 1 112 ? -27.19000 -6.14000  -27.40200 1.000 23.11682 ? 112 MET A SD  1 
ATOM   868  C CE  . MET A 1 112 ? -25.81200 -6.04500  -26.22500 1.000 23.26147 ? 112 MET A CE  1 
ATOM   869  N N   . VAL A 1 113 ? -30.02200 -2.33700  -23.60100 1.000 22.21432 ? 113 VAL A N   1 
ATOM   870  C CA  . VAL A 1 113 ? -30.11800 -1.06800  -22.88900 1.000 20.44547 ? 113 VAL A CA  1 
ATOM   871  C C   . VAL A 1 113 ? -28.98000 -1.00200  -21.89000 1.000 21.24115 ? 113 VAL A C   1 
ATOM   872  O O   . VAL A 1 113 ? -28.80200 -1.92900  -21.09900 1.000 21.45820 ? 113 VAL A O   1 
ATOM   873  C CB  . VAL A 1 113 ? -31.47700 -0.92800  -22.18000 1.000 24.53066 ? 113 VAL A CB  1 
ATOM   874  C CG1 . VAL A 1 113 ? -31.46200 0.21900   -21.15900 1.000 19.97456 ? 113 VAL A CG1 1 
ATOM   875  C CG2 . VAL A 1 113 ? -32.59900 -0.75500  -23.20600 1.000 20.94090 ? 113 VAL A CG2 1 
ATOM   876  N N   . GLU A 1 114 ? -28.20400 0.08300   -21.93500 1.000 20.42862 ? 114 GLU A N   1 
ATOM   877  C CA  . GLU A 1 114 ? -27.15300 0.36000   -20.96100 1.000 23.79999 ? 114 GLU A CA  1 
ATOM   878  C C   . GLU A 1 114 ? -27.34600 1.78400   -20.47200 1.000 20.21977 ? 114 GLU A C   1 
ATOM   879  O O   . GLU A 1 114 ? -27.69700 2.66600   -21.26100 1.000 22.72288 ? 114 GLU A O   1 
ATOM   880  C CB  . GLU A 1 114 ? -25.72700 0.17100   -21.55400 1.000 24.62860 ? 114 GLU A CB  1 
ATOM   881  C CG  . GLU A 1 114 ? -25.52500 -1.16500  -22.27500 1.000 23.99618 ? 114 GLU A CG  1 
ATOM   882  C CD  . GLU A 1 114 ? -24.06800 -1.51900  -22.52900 1.000 25.82150 ? 114 GLU A CD  1 
ATOM   883  O OE1 . GLU A 1 114 ? -23.19600 -0.69000  -22.22100 1.000 26.86213 ? 114 GLU A OE1 1 
ATOM   884  O OE2 . GLU A 1 114 ? -23.78700 -2.64200  -23.00900 1.000 27.94547 ? 114 GLU A OE2 1 
ATOM   885  N N   . TYR A 1 115 ? -27.14800 1.99200   -19.16900 1.000 23.43953 ? 115 TYR A N   1 
ATOM   886  C CA  . TYR A 1 115 ? -27.34300 3.30000   -18.53600 1.000 24.58004 ? 115 TYR A CA  1 
ATOM   887  C C   . TYR A 1 115 ? -28.72100 3.86900   -18.86000 1.000 27.88181 ? 115 TYR A C   1 
ATOM   888  O O   . TYR A 1 115 ? -28.88300 5.08500   -19.00200 1.000 23.72647 ? 115 TYR A O   1 
ATOM   889  C CB  . TYR A 1 115 ? -26.26200 4.30000   -18.95100 1.000 23.68361 ? 115 TYR A CB  1 
ATOM   890  C CG  . TYR A 1 115 ? -24.83700 3.96900   -18.53800 1.000 27.46369 ? 115 TYR A CG  1 
ATOM   891  C CD1 . TYR A 1 115 ? -24.35500 4.30600   -17.26800 1.000 28.99576 ? 115 TYR A CD1 1 
ATOM   892  C CD2 . TYR A 1 115 ? -23.96300 3.36500   -19.43500 1.000 25.94872 ? 115 TYR A CD2 1 
ATOM   893  C CE1 . TYR A 1 115 ? -23.04600 4.01900   -16.89700 1.000 29.82285 ? 115 TYR A CE1 1 
ATOM   894  C CE2 . TYR A 1 115 ? -22.65400 3.07600   -19.08100 1.000 24.65181 ? 115 TYR A CE2 1 
ATOM   895  C CZ  . TYR A 1 115 ? -22.19300 3.40300   -17.81700 1.000 27.59569 ? 115 TYR A CZ  1 
ATOM   896  O OH  . TYR A 1 115 ? -20.87100 3.11200   -17.48200 1.000 26.97285 ? 115 TYR A OH  1 
ATOM   897  N N   . GLY A 1 116 ? -29.71000 2.98000   -19.01800 1.000 23.31449 ? 116 GLY A N   1 
ATOM   898  C CA  . GLY A 1 116 ? -31.08800 3.37100   -19.26600 1.000 24.11093 ? 116 GLY A CA  1 
ATOM   899  C C   . GLY A 1 116 ? -31.38900 3.81000   -20.68200 1.000 24.71449 ? 116 GLY A C   1 
ATOM   900  O O   . GLY A 1 116 ? -32.47700 4.33700   -20.93100 1.000 27.88074 ? 116 GLY A O   1 
ATOM   901  N N   . ARG A 1 117 ? -30.46400 3.61900   -21.61600 1.000 24.06287 ? 117 ARG A N   1 
ATOM   902  C CA  . ARG A 1 117 ? -30.62300 4.07800   -22.98300 1.000 24.52248 ? 117 ARG A CA  1 
ATOM   903  C C   . ARG A 1 117 ? -30.32000 2.94600   -23.94200 1.000 24.06066 ? 117 ARG A C   1 
ATOM   904  O O   . ARG A 1 117 ? -29.45300 2.10900   -23.67000 1.000 22.24523 ? 117 ARG A O   1 
ATOM   905  C CB  . ARG A 1 117 ? -29.69600 5.25700   -23.28400 1.000 27.93139 ? 117 ARG A CB  1 
ATOM   906  C CG  . ARG A 1 117 ? -30.02300 6.48800   -22.48000 1.000 27.80651 ? 117 ARG A CG  1 
ATOM   907  C CD  . ARG A 1 117 ? -31.07700 7.35800   -23.19200 1.000 29.49487 ? 117 ARG A CD  1 
ATOM   908  N NE  . ARG A 1 117 ? -31.49700 8.46900   -22.33800 1.000 38.06714 ? 117 ARG A NE  1 
ATOM   909  C CZ  . ARG A 1 117 ? -32.74400 8.71700   -21.95400 1.000 42.87099 ? 117 ARG A CZ  1 
ATOM   910  N NH1 . ARG A 1 117 ? -33.76300 7.97900   -22.37500 1.000 43.32356 ? 117 ARG A NH1 1 
ATOM   911  N NH2 . ARG A 1 117 ? -32.97900 9.74100   -21.13400 1.000 41.66429 ? 117 ARG A NH2 1 
ATOM   912  N N   . PHE A 1 118 ? -31.04500 2.92300   -25.06200 1.000 20.74227 ? 118 PHE A N   1 
ATOM   913  C CA  . PHE A 1 118 ? -30.81100 1.91100   -26.08800 1.000 24.01337 ? 118 PHE A CA  1 
ATOM   914  C C   . PHE A 1 118 ? -29.45300 2.10600   -26.76400 1.000 27.96506 ? 118 PHE A C   1 
ATOM   915  O O   . PHE A 1 118 ? -29.05600 3.23400   -27.08200 1.000 29.10036 ? 118 PHE A O   1 
ATOM   916  C CB  . PHE A 1 118 ? -31.93500 1.95800   -27.12400 1.000 24.02005 ? 118 PHE A CB  1 
ATOM   917  C CG  . PHE A 1 118 ? -33.20400 1.34300   -26.61700 1.000 27.84382 ? 118 PHE A CG  1 
ATOM   918  C CD1 . PHE A 1 118 ? -34.09600 2.09800   -25.88000 1.000 28.39354 ? 118 PHE A CD1 1 
ATOM   919  C CD2 . PHE A 1 118 ? -33.46900 0.00100   -26.81200 1.000 23.89805 ? 118 PHE A CD2 1 
ATOM   920  C CE1 . PHE A 1 118 ? -35.25000 1.53800   -25.37600 1.000 28.04958 ? 118 PHE A CE1 1 
ATOM   921  C CE2 . PHE A 1 118 ? -34.62400 -0.55300  -26.32300 1.000 28.17112 ? 118 PHE A CE2 1 
ATOM   922  C CZ  . PHE A 1 118 ? -35.51600 0.21500   -25.60200 1.000 27.24505 ? 118 PHE A CZ  1 
ATOM   923  N N   . LEU A 1 119 ? -28.74100 0.98600   -26.99700 1.000 20.93153 ? 119 LEU A N   1 
ATOM   924  C CA  . LEU A 1 119 ? -27.41400 1.03400   -27.58300 1.000 22.61440 ? 119 LEU A CA  1 
ATOM   925  C C   . LEU A 1 119 ? -27.48300 1.28700   -29.09400 1.000 27.46532 ? 119 LEU A C   1 
ATOM   926  O O   . LEU A 1 119 ? -28.46500 0.92800   -29.74800 1.000 22.48689 ? 119 LEU A O   1 
ATOM   927  C CB  . LEU A 1 119 ? -26.68000 -0.27400  -27.32500 1.000 22.92734 ? 119 LEU A CB  1 
ATOM   928  C CG  . LEU A 1 119 ? -26.23300 -0.53000  -25.88700 1.000 26.10997 ? 119 LEU A CG  1 
ATOM   929  C CD1 . LEU A 1 119 ? -25.39200 -1.81000  -25.82700 1.000 22.05041 ? 119 LEU A CD1 1 
ATOM   930  C CD2 . LEU A 1 119 ? -25.48000 0.69500   -25.34800 1.000 20.93026 ? 119 LEU A CD2 1 
ATOM   931  N N   . PRO A 1 120 ? -26.44300 1.87800   -29.67500 1.000 26.81841 ? 120 PRO A N   1 
ATOM   932  C CA  . PRO A 1 120 ? -26.38400 2.03000   -31.12900 1.000 29.24534 ? 120 PRO A CA  1 
ATOM   933  C C   . PRO A 1 120 ? -25.75300 0.80100   -31.77000 1.000 27.40646 ? 120 PRO A C   1 
ATOM   934  O O   . PRO A 1 120 ? -25.19900 -0.07200  -31.09300 1.000 25.85084 ? 120 PRO A O   1 
ATOM   935  C CB  . PRO A 1 120 ? -25.48200 3.24400   -31.31400 1.000 31.34976 ? 120 PRO A CB  1 
ATOM   936  C CG  . PRO A 1 120 ? -24.65200 3.29100   -30.09600 1.000 34.52284 ? 120 PRO A CG  1 
ATOM   937  C CD  . PRO A 1 120 ? -25.23500 2.40400   -29.02900 1.000 30.12878 ? 120 PRO A CD  1 
ATOM   938  N N   . GLN A 1 121 ? -25.84400 0.75000   -33.09600 1.000 29.96110 ? 121 GLN A N   1 
ATOM   939  C CA  . GLN A 1 121 ? -25.12300 -0.26900  -33.84000 1.000 31.37046 ? 121 GLN A CA  1 
ATOM   940  C C   . GLN A 1 121 ? -23.62200 -0.09000  -33.62300 1.000 31.27525 ? 121 GLN A C   1 
ATOM   941  O O   . GLN A 1 121 ? -23.14000 1.03200   -33.47200 1.000 30.41663 ? 121 GLN A O   1 
ATOM   942  C CB  . GLN A 1 121 ? -25.44600 -0.20400  -35.33600 1.000 30.65511 ? 121 GLN A CB  1 
ATOM   943  C CG  . GLN A 1 121 ? -26.92800 -0.39400  -35.68800 1.000 34.05303 ? 121 GLN A CG  1 
ATOM   944  C CD  . GLN A 1 121 ? -27.58900 -1.62200  -35.03600 1.000 38.03771 ? 121 GLN A CD  1 
ATOM   945  O OE1 . GLN A 1 121 ? -27.00300 -2.72000  -34.96900 1.000 39.19126 ? 121 GLN A OE1 1 
ATOM   946  N NE2 . GLN A 1 121 ? -28.82400 -1.43600  -34.55700 1.000 33.53980 ? 121 GLN A NE2 1 
ATOM   947  N N   . PRO A 1 122 ? -22.86600 -1.18500  -33.59100 1.000 30.07261 ? 122 PRO A N   1 
ATOM   948  C CA  . PRO A 1 122 ? -21.40500 -1.08700  -33.48900 1.000 30.32412 ? 122 PRO A CA  1 
ATOM   949  C C   . PRO A 1 122 ? -20.80800 -0.14100  -34.52600 1.000 29.45084 ? 122 PRO A C   1 
ATOM   950  O O   . PRO A 1 122 ? -21.19800 -0.15100  -35.69600 1.000 26.56835 ? 122 PRO A O   1 
ATOM   951  C CB  . PRO A 1 122 ? -20.95200 -2.53100  -33.72100 1.000 28.98258 ? 122 PRO A CB  1 
ATOM   952  C CG  . PRO A 1 122 ? -22.07700 -3.33600  -33.17600 1.000 27.21633 ? 122 PRO A CG  1 
ATOM   953  C CD  . PRO A 1 122 ? -23.32600 -2.58000  -33.53600 1.000 28.71757 ? 122 PRO A CD  1 
ATOM   954  N N   . GLY A 1 123 ? -19.84800 0.68200   -34.07500 1.000 31.31811 ? 123 GLY A N   1 
ATOM   955  C CA  . GLY A 1 123 ? -19.23000 1.70900   -34.88700 1.000 31.75465 ? 123 GLY A CA  1 
ATOM   956  C C   . GLY A 1 123 ? -19.89200 3.07100   -34.80000 1.000 36.18661 ? 123 GLY A C   1 
ATOM   957  O O   . GLY A 1 123 ? -19.31500 4.05600   -35.27200 1.000 36.70282 ? 123 GLY A O   1 
ATOM   958  N N   . HIS A 1 124 ? -21.07800 3.15600   -34.20300 1.000 32.86964 ? 124 HIS A N   1 
ATOM   959  C CA  . HIS A 1 124 ? -21.90000 4.35800   -34.17100 1.000 33.57989 ? 124 HIS A CA  1 
ATOM   960  C C   . HIS A 1 124 ? -21.91200 4.93100   -32.74400 1.000 37.04020 ? 124 HIS A C   1 
ATOM   961  O O   . HIS A 1 124 ? -22.73800 5.77200   -32.37800 1.000 38.07910 ? 124 HIS A O   1 
ATOM   962  C CB  . HIS A 1 124 ? -23.26400 3.97900   -34.79400 1.000 38.75953 ? 124 HIS A CB  1 
ATOM   963  C CG  . HIS A 1 124 ? -24.44900 4.84800   -34.45400 1.000 54.70461 ? 124 HIS A CG  1 
ATOM   964  N ND1 . HIS A 1 124 ? -25.70400 4.30900   -34.22200 1.000 54.57703 ? 124 HIS A ND1 1 
ATOM   965  C CD2 . HIS A 1 124 ? -24.60900 6.19500   -34.39700 1.000 55.15958 ? 124 HIS A CD2 1 
ATOM   966  C CE1 . HIS A 1 124 ? -26.56700 5.28000   -33.97800 1.000 55.40529 ? 124 HIS A CE1 1 
ATOM   967  N NE2 . HIS A 1 124 ? -25.92900 6.43400   -34.07800 1.000 60.30075 ? 124 HIS A NE2 1 
ATOM   968  N N   . GLU A 1 125 ? -20.90600 4.53100   -31.95600 1.000 32.15434 ? 125 GLU A N   1 
ATOM   969  C CA  . GLU A 1 125 ? -20.81500 4.91600   -30.54900 1.000 32.88631 ? 125 GLU A CA  1 
ATOM   970  C C   . GLU A 1 125 ? -20.53900 6.40200   -30.37100 1.000 34.30945 ? 125 GLU A C   1 
ATOM   971  O O   . GLU A 1 125 ? -21.00400 6.99700   -29.39800 1.000 28.62857 ? 125 GLU A O   1 
ATOM   972  C CB  . GLU A 1 125 ? -19.71300 4.08900   -29.86700 1.000 40.71153 ? 125 GLU A CB  1 
ATOM   973  C CG  . GLU A 1 125 ? -20.09800 2.63800   -29.57400 1.000 33.07012 ? 125 GLU A CG  1 
ATOM   974  C CD  . GLU A 1 125 ? -19.79900 1.74000   -30.76500 1.000 37.21063 ? 125 GLU A CD  1 
ATOM   975  O OE1 . GLU A 1 125 ? -19.20400 2.25200   -31.74400 1.000 36.44252 ? 125 GLU A OE1 1 
ATOM   976  O OE2 . GLU A 1 125 ? -20.16300 0.54000   -30.74000 1.000 32.69697 ? 125 GLU A OE2 1 
ATOM   977  N N   . GLY A 1 126 ? -19.79100 7.00600   -31.28400 1.000 34.72363 ? 126 GLY A N   1 
ATOM   978  C CA  . GLY A 1 126 ? -19.41900 8.40000   -31.16800 1.000 35.81724 ? 126 GLY A CA  1 
ATOM   979  C C   . GLY A 1 126 ? -20.57500 9.37600   -31.24400 1.000 36.27907 ? 126 GLY A C   1 
ATOM   980  O O   . GLY A 1 126 ? -20.75500 10.19100  -30.33300 1.000 30.41551 ? 126 GLY A O   1 
ATOM   981  N N   . GLU A 1 127 ? -21.34900 9.30800   -32.33200 1.000 30.75949 ? 127 GLU A N   1 
ATOM   982  C CA  . GLU A 1 127 ? -22.50700 10.18100  -32.49200 1.000 39.58577 ? 127 GLU A CA  1 
ATOM   983  C C   . GLU A 1 127 ? -23.53500 9.92100   -31.40500 1.000 38.34148 ? 127 GLU A C   1 
ATOM   984  O O   . GLU A 1 127 ? -24.15000 10.85400  -30.87600 1.000 35.98304 ? 127 GLU A O   1 
ATOM   985  C CB  . GLU A 1 127 ? -23.11700 9.96100   -33.87200 1.000 45.23550 ? 127 GLU A CB  1 
ATOM   986  C CG  . GLU A 1 127 ? -24.48600 10.57000  -34.09300 1.000 53.38897 ? 127 GLU A CG  1 
ATOM   987  C CD  . GLU A 1 127 ? -24.70800 10.99500  -35.54700 1.000 65.51235 ? 127 GLU A CD  1 
ATOM   988  O OE1 . GLU A 1 127 ? -24.22600 12.09200  -35.93700 1.000 69.80584 ? 127 GLU A OE1 1 
ATOM   989  O OE2 . GLU A 1 127 ? -25.33400 10.21500  -36.30700 1.000 67.46910 ? 127 GLU A OE2 1 
ATOM   990  N N   . TRP A 1 128 ? -23.73000 8.64600   -31.06800 1.000 39.02189 ? 128 TRP A N   1 
ATOM   991  C CA  . TRP A 1 128 ? -24.64100 8.24800   -30.00000 1.000 36.03019 ? 128 TRP A CA  1 
ATOM   992  C C   . TRP A 1 128 ? -24.35900 9.00800   -28.70600 1.000 33.27949 ? 128 TRP A C   1 
ATOM   993  O O   . TRP A 1 128 ? -25.28100 9.50100   -28.04300 1.000 33.09226 ? 128 TRP A O   1 
ATOM   994  C CB  . TRP A 1 128 ? -24.49600 6.74400   -29.79300 1.000 28.54048 ? 128 TRP A CB  1 
ATOM   995  C CG  . TRP A 1 128 ? -25.37000 6.14500   -28.77700 1.000 28.20116 ? 128 TRP A CG  1 
ATOM   996  C CD1 . TRP A 1 128 ? -26.68400 5.82000   -28.91700 1.000 28.15314 ? 128 TRP A CD1 1 
ATOM   997  C CD2 . TRP A 1 128 ? -24.99700 5.76400   -27.44500 1.000 33.43389 ? 128 TRP A CD2 1 
ATOM   998  N NE1 . TRP A 1 128 ? -27.15500 5.25900   -27.76000 1.000 33.24931 ? 128 TRP A NE1 1 
ATOM   999  C CE2 . TRP A 1 128 ? -26.14200 5.21600   -26.83600 1.000 30.66281 ? 128 TRP A CE2 1 
ATOM   1000 C CE3 . TRP A 1 128 ? -23.80500 5.84300   -26.70500 1.000 31.26150 ? 128 TRP A CE3 1 
ATOM   1001 C CZ2 . TRP A 1 128 ? -26.13300 4.73700   -25.51600 1.000 28.57363 ? 128 TRP A CZ2 1 
ATOM   1002 C CZ3 . TRP A 1 128 ? -23.80000 5.37100   -25.40200 1.000 35.53861 ? 128 TRP A CZ3 1 
ATOM   1003 C CH2 . TRP A 1 128 ? -24.96000 4.82100   -24.82000 1.000 27.14540 ? 128 TRP A CH2 1 
ATOM   1004 N N   . PHE A 1 129 ? -23.08000 9.12400   -28.34800 1.000 31.58103 ? 129 PHE A N   1 
ATOM   1005 C CA  . PHE A 1 129 ? -22.69700 9.73100   -27.08200 1.000 36.00646 ? 129 PHE A CA  1 
ATOM   1006 C C   . PHE A 1 129 ? -23.11200 11.19200  -26.99700 1.000 34.85797 ? 129 PHE A C   1 
ATOM   1007 O O   . PHE A 1 129 ? -23.49900 11.65300  -25.92200 1.000 34.44111 ? 129 PHE A O   1 
ATOM   1008 C CB  . PHE A 1 129 ? -21.18600 9.59000   -26.88100 1.000 35.18401 ? 129 PHE A CB  1 
ATOM   1009 C CG  . PHE A 1 129 ? -20.70700 10.04600  -25.54200 1.000 34.47222 ? 129 PHE A CG  1 
ATOM   1010 C CD1 . PHE A 1 129 ? -20.96700 9.29400   -24.41200 1.000 35.51124 ? 129 PHE A CD1 1 
ATOM   1011 C CD2 . PHE A 1 129 ? -20.00000 11.23000  -25.41000 1.000 36.60055 ? 129 PHE A CD2 1 
ATOM   1012 C CE1 . PHE A 1 129 ? -20.53400 9.71600   -23.16300 1.000 32.04017 ? 129 PHE A CE1 1 
ATOM   1013 C CE2 . PHE A 1 129 ? -19.55600 11.65000  -24.16800 1.000 35.43138 ? 129 PHE A CE2 1 
ATOM   1014 C CZ  . PHE A 1 129 ? -19.82400 10.88600  -23.04200 1.000 34.82909 ? 129 PHE A CZ  1 
ATOM   1015 N N   . ASP A 1 130 ? -23.08200 11.92600  -28.11600 1.000 43.85372 ? 130 ASP A N   1 
ATOM   1016 C CA  . ASP A 1 130 ? -23.29300 13.36900  -28.04700 1.000 42.30549 ? 130 ASP A CA  1 
ATOM   1017 C C   . ASP A 1 130 ? -24.75800 13.77700  -27.97800 1.000 42.64486 ? 130 ASP A C   1 
ATOM   1018 O O   . ASP A 1 130 ? -25.06200 14.82500  -27.39900 1.000 53.57903 ? 130 ASP A O   1 
ATOM   1019 C CB  . ASP A 1 130 ? -22.60300 14.04800  -29.21900 1.000 50.23556 ? 130 ASP A CB  1 
ATOM   1020 C CG  . ASP A 1 130 ? -21.09400 13.96500  -29.11100 1.000 52.31753 ? 130 ASP A CG  1 
ATOM   1021 O OD1 . ASP A 1 130 ? -20.53600 14.50600  -28.12200 1.000 64.71095 ? 130 ASP A OD1 1 
ATOM   1022 O OD2 . ASP A 1 130 ? -20.46400 13.35400  -29.99400 1.000 42.70344 ? 130 ASP A OD2 1 
ATOM   1023 N N   . ASN A 1 131 ? -25.68300 12.99700  -28.53500 1.000 41.45182 ? 131 ASN A N   1 
ATOM   1024 C CA  . ASN A 1 131 ? -27.08900 13.33500  -28.32200 1.000 44.64176 ? 131 ASN A CA  1 
ATOM   1025 C C   . ASN A 1 131 ? -27.64000 12.80000  -27.01000 1.000 42.27929 ? 131 ASN A C   1 
ATOM   1026 O O   . ASN A 1 131 ? -28.83900 12.96600  -26.74300 1.000 51.37062 ? 131 ASN A O   1 
ATOM   1027 C CB  . ASN A 1 131 ? -27.95500 12.86900  -29.48600 1.000 53.23632 ? 131 ASN A CB  1 
ATOM   1028 C CG  . ASN A 1 131 ? -28.00100 13.88600  -30.60800 1.000 60.77095 ? 131 ASN A CG  1 
ATOM   1029 O OD1 . ASN A 1 131 ? -29.06000 14.48100  -30.88700 1.000 62.10036 ? 131 ASN A OD1 1 
ATOM   1030 N ND2 . ASN A 1 131 ? -26.85400 14.10000  -31.26100 1.000 50.28003 ? 131 ASN A ND2 1 
ATOM   1031 N N   . LEU A 1 132 ? -26.80000 12.16300  -26.19900 1.000 42.11519 ? 132 LEU A N   1 
ATOM   1032 C CA  . LEU A 1 132 ? -27.11100 12.00500  -24.78800 1.000 38.06232 ? 132 LEU A CA  1 
ATOM   1033 C C   . LEU A 1 132 ? -27.09900 13.37100  -24.11700 1.000 33.35553 ? 132 LEU A C   1 
ATOM   1034 O O   . LEU A 1 132 ? -26.36600 14.27300  -24.52200 1.000 27.72359 ? 132 LEU A O   1 
ATOM   1035 C CB  . LEU A 1 132 ? -26.09300 11.07700  -24.12300 1.000 33.58572 ? 132 LEU A CB  1 
ATOM   1036 C CG  . LEU A 1 132 ? -26.05200 9.65100   -24.64700 1.000 35.02161 ? 132 LEU A CG  1 
ATOM   1037 C CD1 . LEU A 1 132 ? -25.08800 8.80700   -23.85500 1.000 33.67247 ? 132 LEU A CD1 1 
ATOM   1038 C CD2 . LEU A 1 132 ? -27.43700 9.05900   -24.57800 1.000 34.99794 ? 132 LEU A CD2 1 
ATOM   1039 N N   . SER A 1 133 ? -27.92800 13.51400  -23.08900 1.000 37.30597 ? 133 SER A N   1 
ATOM   1040 C CA  . SER A 1 133 ? -27.93900 14.72700  -22.29100 1.000 37.34322 ? 133 SER A CA  1 
ATOM   1041 C C   . SER A 1 133 ? -26.59500 14.92000  -21.58300 1.000 35.39281 ? 133 SER A C   1 
ATOM   1042 O O   . SER A 1 133 ? -25.76800 14.01000  -21.48000 1.000 31.35447 ? 133 SER A O   1 
ATOM   1043 C CB  . SER A 1 133 ? -29.07700 14.69200  -21.26600 1.000 32.97956 ? 133 SER A CB  1 
ATOM   1044 O OG  . SER A 1 133 ? -28.90900 13.62700  -20.35900 1.000 36.25698 ? 133 SER A OG  1 
ATOM   1045 N N   . SER A 1 134 ? -26.39200 16.13600  -21.07600 1.000 38.54964 ? 134 SER A N   1 
ATOM   1046 C CA  . SER A 1 134 ? -25.14100 16.45700  -20.40100 1.000 37.57901 ? 134 SER A CA  1 
ATOM   1047 C C   . SER A 1 134 ? -24.90400 15.55500  -19.18400 1.000 29.46569 ? 134 SER A C   1 
ATOM   1048 O O   . SER A 1 134 ? -23.80600 15.02200  -19.00600 1.000 32.61293 ? 134 SER A O   1 
ATOM   1049 C CB  . SER A 1 134 ? -25.14200 17.93600  -20.01600 1.000 38.58003 ? 134 SER A CB  1 
ATOM   1050 O OG  . SER A 1 134 ? -26.18700 18.22000  -19.09100 1.000 45.28398 ? 134 SER A OG  1 
ATOM   1051 N N   . ASP A 1 135 ? -25.92400 15.35200  -18.34200 1.000 30.77209 ? 135 ASP A N   1 
ATOM   1052 C CA  . ASP A 1 135 ? -25.72200 14.55300  -17.12700 1.000 33.89562 ? 135 ASP A CA  1 
ATOM   1053 C C   . ASP A 1 135 ? -25.47600 13.08100  -17.43500 1.000 34.50558 ? 135 ASP A C   1 
ATOM   1054 O O   . ASP A 1 135 ? -24.69600 12.42500  -16.73300 1.000 33.11099 ? 135 ASP A O   1 
ATOM   1055 C CB  . ASP A 1 135 ? -26.91000 14.69800  -16.17500 1.000 36.86657 ? 135 ASP A CB  1 
ATOM   1056 C CG  . ASP A 1 135 ? -26.98800 16.07500  -15.53800 1.000 43.03366 ? 135 ASP A CG  1 
ATOM   1057 O OD1 . ASP A 1 135 ? -26.03400 16.86200  -15.71100 1.000 33.38538 ? 135 ASP A OD1 1 
ATOM   1058 O OD2 . ASP A 1 135 ? -27.99800 16.37300  -14.86900 1.000 49.08143 ? 135 ASP A OD2 1 
ATOM   1059 N N   . GLU A 1 136 ? -26.14700 12.53800  -18.45600 1.000 32.01865 ? 136 GLU A N   1 
ATOM   1060 C CA  . GLU A 1 136 ? -25.89800 11.15800  -18.86500 1.000 30.63580 ? 136 GLU A CA  1 
ATOM   1061 C C   . GLU A 1 136 ? -24.46200 10.98200  -19.33500 1.000 31.99871 ? 136 GLU A C   1 
ATOM   1062 O O   . GLU A 1 136 ? -23.77900 10.03000  -18.93500 1.000 30.60165 ? 136 GLU A O   1 
ATOM   1063 C CB  . GLU A 1 136 ? -26.85600 10.76200  -19.98900 1.000 27.61265 ? 136 GLU A CB  1 
ATOM   1064 C CG  . GLU A 1 136 ? -28.28300 10.53900  -19.57300 1.000 36.46455 ? 136 GLU A CG  1 
ATOM   1065 C CD  . GLU A 1 136 ? -29.20000 10.42500  -20.77500 1.000 37.68504 ? 136 GLU A CD  1 
ATOM   1066 O OE1 . GLU A 1 136 ? -29.30900 11.40300  -21.53500 1.000 41.15348 ? 136 GLU A OE1 1 
ATOM   1067 O OE2 . GLU A 1 136 ? -29.79200 9.34700   -20.97200 1.000 32.84418 ? 136 GLU A OE2 1 
ATOM   1068 N N   . ARG A 1 137 ? -24.00600 11.86400  -20.23900 1.000 26.84510 ? 137 ARG A N   1 
ATOM   1069 C CA  . ARG A 1 137 ? -22.61100 11.82700  -20.66100 1.000 30.01117 ? 137 ARG A CA  1 
ATOM   1070 C C   . ARG A 1 137 ? -21.68600 11.92700  -19.45200 1.000 35.12592 ? 137 ARG A C   1 
ATOM   1071 O O   . ARG A 1 137 ? -20.65000 11.24800  -19.39200 1.000 36.39276 ? 137 ARG A O   1 
ATOM   1072 C CB  . ARG A 1 137 ? -22.31400 12.95400  -21.66800 1.000 34.08816 ? 137 ARG A CB  1 
ATOM   1073 C CG  . ARG A 1 137 ? -23.14400 12.94800  -22.95700 1.000 34.99537 ? 137 ARG A CG  1 
ATOM   1074 C CD  . ARG A 1 137 ? -22.54900 13.81500  -24.08700 1.000 34.30789 ? 137 ARG A CD  1 
ATOM   1075 N NE  . ARG A 1 137 ? -22.15300 15.13700  -23.62700 1.000 36.71684 ? 137 ARG A NE  1 
ATOM   1076 C CZ  . ARG A 1 137 ? -22.94700 16.19900  -23.62800 1.000 41.10055 ? 137 ARG A CZ  1 
ATOM   1077 N NH1 . ARG A 1 137 ? -24.18400 16.13100  -24.08700 1.000 36.22047 ? 137 ARG A NH1 1 
ATOM   1078 N NH2 . ARG A 1 137 ? -22.49300 17.35300  -23.13900 1.000 32.42013 ? 137 ARG A NH2 1 
ATOM   1079 N N   . ALA A 1 138 ? -22.07000 12.73100  -18.45400 1.000 33.08061 ? 138 ALA A N   1 
ATOM   1080 C CA  . ALA A 1 138 ? -21.18400 12.98900  -17.32100 1.000 32.58588 ? 138 ALA A CA  1 
ATOM   1081 C C   . ALA A 1 138 ? -21.08600 11.78300  -16.39600 1.000 33.55578 ? 138 ALA A C   1 
ATOM   1082 O O   . ALA A 1 138 ? -19.99300 11.43400  -15.93800 1.000 31.47538 ? 138 ALA A O   1 
ATOM   1083 C CB  . ALA A 1 138 ? -21.66300 14.21900  -16.55200 1.000 33.21161 ? 138 ALA A CB  1 
ATOM   1084 N N   . PHE A 1 139 ? -22.22100 11.15500  -16.08000 1.000 29.92384 ? 139 PHE A N   1 
ATOM   1085 C CA  . PHE A 1 139 ? -22.20400 9.94700   -15.25800 1.000 30.61438 ? 139 PHE A CA  1 
ATOM   1086 C C   . PHE A 1 139 ? -21.38700 8.84900   -15.92400 1.000 34.70950 ? 139 PHE A C   1 
ATOM   1087 O O   . PHE A 1 139 ? -20.60000 8.15700   -15.26900 1.000 36.26381 ? 139 PHE A O   1 
ATOM   1088 C CB  . PHE A 1 139 ? -23.63600 9.46500   -15.01100 1.000 36.93173 ? 139 PHE A CB  1 
ATOM   1089 C CG  . PHE A 1 139 ? -23.72800 8.17600   -14.22400 1.000 42.03823 ? 139 PHE A CG  1 
ATOM   1090 C CD1 . PHE A 1 139 ? -22.97400 7.97900   -13.07500 1.000 52.57867 ? 139 PHE A CD1 1 
ATOM   1091 C CD2 . PHE A 1 139 ? -24.55400 7.15500   -14.64800 1.000 38.85119 ? 139 PHE A CD2 1 
ATOM   1092 C CE1 . PHE A 1 139 ? -23.06500 6.79100   -12.35500 1.000 53.27087 ? 139 PHE A CE1 1 
ATOM   1093 C CE2 . PHE A 1 139 ? -24.65300 5.97000   -13.93400 1.000 43.13630 ? 139 PHE A CE2 1 
ATOM   1094 C CZ  . PHE A 1 139 ? -23.90900 5.78800   -12.79100 1.000 47.11902 ? 139 PHE A CZ  1 
ATOM   1095 N N   . MET A 1 140 ? -21.56900 8.68900   -17.23500 1.000 34.83725 ? 140 MET A N   1 
ATOM   1096 C CA  . MET A 1 140 ? -20.82600 7.71400   -18.02800 1.000 31.58978 ? 140 MET A CA  1 
ATOM   1097 C C   . MET A 1 140 ? -19.32200 7.96500   -17.96900 1.000 36.73863 ? 140 MET A C   1 
ATOM   1098 O O   . MET A 1 140 ? -18.53100 7.02500   -17.79900 1.000 35.27439 ? 140 MET A O   1 
ATOM   1099 C CB  . MET A 1 140 ? -21.31500 7.79800   -19.47000 1.000 34.32333 ? 140 MET A CB  1 
ATOM   1100 C CG  . MET A 1 140 ? -21.80800 6.53100   -20.05600 1.000 33.51926 ? 140 MET A CG  1 
ATOM   1101 S SD  . MET A 1 140 ? -22.79700 6.87500   -21.52200 1.000 34.09908 ? 140 MET A SD  1 
ATOM   1102 C CE  . MET A 1 140 ? -24.46600 6.87700   -20.89300 1.000 27.73318 ? 140 MET A CE  1 
ATOM   1103 N N   . GLU A 1 141 ? -18.91500 9.23000   -18.13900 1.000 38.34357 ? 141 GLU A N   1 
ATOM   1104 C CA  . GLU A 1 141 ? -17.49900 9.58700   -18.18800 1.000 36.99453 ? 141 GLU A CA  1 
ATOM   1105 C C   . GLU A 1 141 ? -16.76300 9.15300   -16.92800 1.000 38.33859 ? 141 GLU A C   1 
ATOM   1106 O O   . GLU A 1 141 ? -15.60100 8.74000   -16.99500 1.000 37.40880 ? 141 GLU A O   1 
ATOM   1107 C CB  . GLU A 1 141 ? -17.34300 11.09600  -18.37700 1.000 32.86543 ? 141 GLU A CB  1 
ATOM   1108 C CG  . GLU A 1 141 ? -17.11000 11.53900  -19.79800 1.000 40.40874 ? 141 GLU A CG  1 
ATOM   1109 C CD  . GLU A 1 141 ? -17.12700 13.05600  -19.92100 1.000 51.90206 ? 141 GLU A CD  1 
ATOM   1110 O OE1 . GLU A 1 141 ? -17.99200 13.70600  -19.27900 1.000 49.33824 ? 141 GLU A OE1 1 
ATOM   1111 O OE2 . GLU A 1 141 ? -16.25900 13.59500  -20.63800 1.000 56.43311 ? 141 GLU A OE2 1 
ATOM   1112 N N   . THR A 1 142 ? -17.41500 9.25200   -15.76500 1.000 37.50501 ? 142 THR A N   1 
ATOM   1113 C CA  . THR A 1 142 ? -16.75900 8.85200   -14.52300 1.000 41.31216 ? 142 THR A CA  1 
ATOM   1114 C C   . THR A 1 142 ? -16.36100 7.37800   -14.50700 1.000 40.82638 ? 142 THR A C   1 
ATOM   1115 O O   . THR A 1 142 ? -15.49700 7.00000   -13.71400 1.000 46.77049 ? 142 THR A O   1 
ATOM   1116 C CB  . THR A 1 142 ? -17.65200 9.13200   -13.31800 1.000 39.29697 ? 142 THR A CB  1 
ATOM   1117 O OG1 . THR A 1 142 ? -18.59500 8.06200   -13.18200 1.000 43.01736 ? 142 THR A OG1 1 
ATOM   1118 C CG2 . THR A 1 142 ? -18.37700 10.45600  -13.46600 1.000 37.59983 ? 142 THR A CG2 1 
ATOM   1119 N N   . ASN A 1 143 ? -16.96500 6.53400   -15.34100 1.000 39.82945 ? 143 ASN A N   1 
ATOM   1120 C CA  . ASN A 1 143 ? -16.61400 5.10600   -15.36400 1.000 39.87175 ? 143 ASN A CA  1 
ATOM   1121 C C   . ASN A 1 143 ? -15.53600 4.78700   -16.40200 1.000 36.93062 ? 143 ASN A C   1 
ATOM   1122 O O   . ASN A 1 143 ? -15.69100 3.88600   -17.22900 1.000 37.91978 ? 143 ASN A O   1 
ATOM   1123 C CB  . ASN A 1 143 ? -17.85400 4.24800   -15.60500 1.000 32.83803 ? 143 ASN A CB  1 
ATOM   1124 C CG  . ASN A 1 143 ? -18.96800 4.52600   -14.61700 1.000 40.34186 ? 143 ASN A CG  1 
ATOM   1125 O OD1 . ASN A 1 143 ? -20.11700 4.18100   -14.86200 1.000 43.83945 ? 143 ASN A OD1 1 
ATOM   1126 N ND2 . ASN A 1 143 ? -18.61900 5.09300   -13.46200 1.000 41.74937 ? 143 ASN A ND2 1 
ATOM   1127 N N   . VAL A 1 144 ? -14.42100 5.50900   -16.36800 1.000 35.10120 ? 144 VAL A N   1 
ATOM   1128 C CA  . VAL A 1 144 ? -13.25900 5.19800   -17.19400 1.000 39.39183 ? 144 VAL A CA  1 
ATOM   1129 C C   . VAL A 1 144 ? -12.02800 5.08100   -16.29800 1.000 37.52641 ? 144 VAL A C   1 
ATOM   1130 O O   . VAL A 1 144 ? -11.83600 5.88300   -15.37800 1.000 42.40040 ? 144 VAL A O   1 
ATOM   1131 C CB  . VAL A 1 144 ? -13.05300 6.25300   -18.30400 1.000 40.20214 ? 144 VAL A CB  1 
ATOM   1132 C CG1 . VAL A 1 144 ? -11.83200 5.91600   -19.13600 1.000 35.14752 ? 144 VAL A CG1 1 
ATOM   1133 C CG2 . VAL A 1 144 ? -14.30300 6.31700   -19.20300 1.000 35.28021 ? 144 VAL A CG2 1 
ATOM   1134 N N   . ASP A 1 145 ? -11.20900 4.06500   -16.55800 1.000 43.86408 ? 145 ASP A N   1 
ATOM   1135 C CA  . ASP A 1 145 ? -10.02400 3.77800   -15.75600 1.000 44.31344 ? 145 ASP A CA  1 
ATOM   1136 C C   . ASP A 1 145 ? -8.84900  3.48300   -16.69200 1.000 46.77752 ? 145 ASP A C   1 
ATOM   1137 O O   . ASP A 1 145 ? -8.11700  4.38300   -17.11100 1.000 51.82675 ? 145 ASP A O   1 
ATOM   1138 C CB  . ASP A 1 145 ? -10.30800 2.59600   -14.81300 1.000 48.16573 ? 145 ASP A CB  1 
ATOM   1139 C CG  . ASP A 1 145 ? -9.07500  2.12900   -14.04400 1.000 51.19088 ? 145 ASP A CG  1 
ATOM   1140 O OD1 . ASP A 1 145 ? -8.07500  1.72400   -14.67600 1.000 56.16511 ? 145 ASP A OD1 1 
ATOM   1141 O OD2 . ASP A 1 145 ? -9.12600  2.12700   -12.80000 1.000 50.36141 ? 145 ASP A OD2 1 
ATOM   1142 N N   . PRO B 1 1   ? -40.96800 -16.55700 -20.09100 1.000 25.87341 ? 1   PRO B N   1 
ATOM   1143 C CA  . PRO B 1 1   ? -39.61300 -16.00000 -20.05900 1.000 23.51670 ? 1   PRO B CA  1 
ATOM   1144 C C   . PRO B 1 1   ? -38.94500 -16.18600 -18.71500 1.000 25.91712 ? 1   PRO B C   1 
ATOM   1145 O O   . PRO B 1 1   ? -39.63100 -16.38000 -17.69900 1.000 27.75079 ? 1   PRO B O   1 
ATOM   1146 C CB  . PRO B 1 1   ? -39.84400 -14.51600 -20.31700 1.000 25.44102 ? 1   PRO B CB  1 
ATOM   1147 C CG  . PRO B 1 1   ? -41.17500 -14.25400 -19.67900 1.000 27.01232 ? 1   PRO B CG  1 
ATOM   1148 C CD  . PRO B 1 1   ? -41.99600 -15.51600 -19.86800 1.000 28.50374 ? 1   PRO B CD  1 
ATOM   1149 N N   . VAL B 1 2   ? -37.61900 -16.11800 -18.70000 1.000 20.55291 ? 2   VAL B N   1 
ATOM   1150 C CA  . VAL B 1 2   ? -36.86400 -15.99300 -17.46600 1.000 22.08376 ? 2   VAL B CA  1 
ATOM   1151 C C   . VAL B 1 2   ? -36.12500 -14.67100 -17.51700 1.000 23.90480 ? 2   VAL B C   1 
ATOM   1152 O O   . VAL B 1 2   ? -35.43700 -14.37000 -18.50000 1.000 22.59073 ? 2   VAL B O   1 
ATOM   1153 C CB  . VAL B 1 2   ? -35.89600 -17.16400 -17.24600 1.000 25.58502 ? 2   VAL B CB  1 
ATOM   1154 C CG1 . VAL B 1 2   ? -34.94100 -16.84000 -16.12200 1.000 22.89823 ? 2   VAL B CG1 1 
ATOM   1155 C CG2 . VAL B 1 2   ? -36.68600 -18.46500 -16.96100 1.000 22.43316 ? 2   VAL B CG2 1 
ATOM   1156 N N   . TYR B 1 3   ? -36.31800 -13.86600 -16.48100 1.000 22.71706 ? 3   TYR B N   1 
ATOM   1157 C CA  . TYR B 1 3   ? -35.58100 -12.63200 -16.25800 1.000 22.71373 ? 3   TYR B CA  1 
ATOM   1158 C C   . TYR B 1 3   ? -34.56300 -12.91500 -15.15100 1.000 25.98740 ? 3   TYR B C   1 
ATOM   1159 O O   . TYR B 1 3   ? -34.93600 -13.15200 -13.99500 1.000 25.22129 ? 3   TYR B O   1 
ATOM   1160 C CB  . TYR B 1 3   ? -36.53900 -11.48900 -15.88200 1.000 22.85980 ? 3   TYR B CB  1 
ATOM   1161 C CG  . TYR B 1 3   ? -37.38100 -10.97300 -17.05100 1.000 23.38566 ? 3   TYR B CG  1 
ATOM   1162 C CD1 . TYR B 1 3   ? -36.90000 -9.97600  -17.89800 1.000 22.66458 ? 3   TYR B CD1 1 
ATOM   1163 C CD2 . TYR B 1 3   ? -38.64100 -11.50900 -17.32200 1.000 25.88414 ? 3   TYR B CD2 1 
ATOM   1164 C CE1 . TYR B 1 3   ? -37.64700 -9.50600  -18.95400 1.000 19.33354 ? 3   TYR B CE1 1 
ATOM   1165 C CE2 . TYR B 1 3   ? -39.40900 -11.04400 -18.38900 1.000 22.72117 ? 3   TYR B CE2 1 
ATOM   1166 C CZ  . TYR B 1 3   ? -38.90200 -10.04200 -19.19900 1.000 24.57091 ? 3   TYR B CZ  1 
ATOM   1167 O OH  . TYR B 1 3   ? -39.63900 -9.57400  -20.27900 1.000 23.32714 ? 3   TYR B OH  1 
ATOM   1168 N N   . MET B 1 4   ? -33.28400 -12.92400 -15.50900 1.000 22.55561 ? 4   MET B N   1 
ATOM   1169 C CA  . MET B 1 4   ? -32.21700 -12.92200 -14.52500 1.000 23.75902 ? 4   MET B CA  1 
ATOM   1170 C C   . MET B 1 4   ? -31.89600 -11.47800 -14.15100 1.000 25.25265 ? 4   MET B C   1 
ATOM   1171 O O   . MET B 1 4   ? -31.70400 -10.63300 -15.03000 1.000 23.44294 ? 4   MET B O   1 
ATOM   1172 C CB  . MET B 1 4   ? -30.97600 -13.63800 -15.07300 1.000 24.39269 ? 4   MET B CB  1 
ATOM   1173 C CG  . MET B 1 4   ? -31.25800 -14.99200 -15.74200 1.000 23.89515 ? 4   MET B CG  1 
ATOM   1174 S SD  . MET B 1 4   ? -31.80100 -16.32100 -14.60600 1.000 28.60716 ? 4   MET B SD  1 
ATOM   1175 C CE  . MET B 1 4   ? -30.38500 -16.42200 -13.52100 1.000 22.99939 ? 4   MET B CE  1 
ATOM   1176 N N   . VAL B 1 5   ? -31.86300 -11.18800 -12.85400 1.000 24.11819 ? 5   VAL B N   1 
ATOM   1177 C CA  . VAL B 1 5   ? -31.69800 -9.81500  -12.36300 1.000 26.51940 ? 5   VAL B CA  1 
ATOM   1178 C C   . VAL B 1 5   ? -30.46100 -9.79000  -11.47300 1.000 24.52170 ? 5   VAL B C   1 
ATOM   1179 O O   . VAL B 1 5   ? -30.45700 -10.39100 -10.39100 1.000 25.11318 ? 5   VAL B O   1 
ATOM   1180 C CB  . VAL B 1 5   ? -32.94600 -9.31900  -11.60900 1.000 23.91467 ? 5   VAL B CB  1 
ATOM   1181 C CG1 . VAL B 1 5   ? -32.74800 -7.90700  -11.11800 1.000 21.68058 ? 5   VAL B CG1 1 
ATOM   1182 C CG2 . VAL B 1 5   ? -34.19100 -9.39300  -12.52300 1.000 23.12020 ? 5   VAL B CG2 1 
ATOM   1183 N N   . TYR B 1 6   ? -29.42100 -9.08300  -11.92100 1.000 22.57884 ? 6   TYR B N   1 
ATOM   1184 C CA  . TYR B 1 6   ? -28.12900 -9.04700  -11.23800 1.000 26.30757 ? 6   TYR B CA  1 
ATOM   1185 C C   . TYR B 1 6   ? -28.00600 -7.75900  -10.42900 1.000 27.96800 ? 6   TYR B C   1 
ATOM   1186 O O   . TYR B 1 6   ? -27.93700 -6.65700  -10.98300 1.000 23.16150 ? 6   TYR B O   1 
ATOM   1187 C CB  . TYR B 1 6   ? -26.98100 -9.20400  -12.23000 1.000 22.77140 ? 6   TYR B CB  1 
ATOM   1188 C CG  . TYR B 1 6   ? -27.07700 -10.52200 -12.96200 1.000 23.13976 ? 6   TYR B CG  1 
ATOM   1189 C CD1 . TYR B 1 6   ? -26.51600 -11.67300 -12.43800 1.000 21.13815 ? 6   TYR B CD1 1 
ATOM   1190 C CD2 . TYR B 1 6   ? -27.75800 -10.61200 -14.16700 1.000 20.83660 ? 6   TYR B CD2 1 
ATOM   1191 C CE1 . TYR B 1 6   ? -26.62700 -12.87400 -13.09800 1.000 24.60987 ? 6   TYR B CE1 1 
ATOM   1192 C CE2 . TYR B 1 6   ? -27.87400 -11.79100 -14.82900 1.000 24.36007 ? 6   TYR B CE2 1 
ATOM   1193 C CZ  . TYR B 1 6   ? -27.31800 -12.92000 -14.30800 1.000 29.78827 ? 6   TYR B CZ  1 
ATOM   1194 O OH  . TYR B 1 6   ? -27.46000 -14.08000 -15.02600 1.000 24.95745 ? 6   TYR B OH  1 
ATOM   1195 N N   . VAL B 1 7   ? -27.98900 -7.91900  -9.10800  1.000 29.07653 ? 7   VAL B N   1 
ATOM   1196 C CA  . VAL B 1 7   ? -28.02400 -6.82300  -8.15700  1.000 24.54352 ? 7   VAL B CA  1 
ATOM   1197 C C   . VAL B 1 7   ? -27.02200 -7.15800  -7.06500  1.000 27.63870 ? 7   VAL B C   1 
ATOM   1198 O O   . VAL B 1 7   ? -26.63200 -8.31200  -6.87900  1.000 26.91228 ? 7   VAL B O   1 
ATOM   1199 C CB  . VAL B 1 7   ? -29.43800 -6.61200  -7.55900  1.000 28.60580 ? 7   VAL B CB  1 
ATOM   1200 C CG1 . VAL B 1 7   ? -30.42900 -6.16200  -8.63400  1.000 22.77626 ? 7   VAL B CG1 1 
ATOM   1201 C CG2 . VAL B 1 7   ? -29.93800 -7.89200  -6.89700  1.000 26.21385 ? 7   VAL B CG2 1 
ATOM   1202 N N   . SER B 1 8   ? -26.60300 -6.13200  -6.34500  1.000 27.18743 ? 8   SER B N   1 
ATOM   1203 C CA  . SER B 1 8   ? -25.71900 -6.33400  -5.21200  1.000 33.08863 ? 8   SER B CA  1 
ATOM   1204 C C   . SER B 1 8   ? -26.49700 -6.78000  -3.98100  1.000 32.91454 ? 8   SER B C   1 
ATOM   1205 O O   . SER B 1 8   ? -27.66200 -6.42900  -3.78500  1.000 29.60456 ? 8   SER B O   1 
ATOM   1206 C CB  . SER B 1 8   ? -24.94300 -5.05600  -4.89200  1.000 33.38394 ? 8   SER B CB  1 
ATOM   1207 O OG  . SER B 1 8   ? -23.93100 -4.86100  -5.85300  1.000 32.95633 ? 8   SER B OG  1 
ATOM   1208 N N   . GLN B 1 9   ? -25.83000 -7.58000  -3.15900  1.000 36.32793 ? 9   GLN B N   1 
ATOM   1209 C CA  . GLN B 1 9   ? -26.35100 -7.98200  -1.86100  1.000 37.38177 ? 9   GLN B CA  1 
ATOM   1210 C C   . GLN B 1 9   ? -26.71700 -6.76600  -1.02300  1.000 33.05192 ? 9   GLN B C   1 
ATOM   1211 O O   . GLN B 1 9   ? -25.96000 -5.79800  -0.94800  1.000 34.14811 ? 9   GLN B O   1 
ATOM   1212 C CB  . GLN B 1 9   ? -25.28600 -8.79900  -1.13900  1.000 44.36294 ? 9   GLN B CB  1 
ATOM   1213 C CG  . GLN B 1 9   ? -25.73700 -10.11800 -0.59400  1.000 49.79264 ? 9   GLN B CG  1 
ATOM   1214 C CD  . GLN B 1 9   ? -24.58300 -11.07400 -0.52100  1.000 51.32163 ? 9   GLN B CD  1 
ATOM   1215 O OE1 . GLN B 1 9   ? -23.41700 -10.65900 -0.56400  1.000 50.91000 ? 9   GLN B OE1 1 
ATOM   1216 N NE2 . GLN B 1 9   ? -24.88800 -12.36000 -0.41300  1.000 61.35297 ? 9   GLN B NE2 1 
ATOM   1217 N N   . ASP B 1 10  ? -27.87700 -6.83200  -0.37600  1.000 37.05292 ? 10  ASP B N   1 
ATOM   1218 C CA  . ASP B 1 10  ? -28.42000 -5.78200  0.48600   1.000 43.17819 ? 10  ASP B CA  1 
ATOM   1219 C C   . ASP B 1 10  ? -28.76700 -4.49000  -0.23600  1.000 37.56143 ? 10  ASP B C   1 
ATOM   1220 O O   . ASP B 1 10  ? -28.97200 -3.45900  0.42600   1.000 45.75159 ? 10  ASP B O   1 
ATOM   1221 C CB  . ASP B 1 10  ? -27.49000 -5.41500  1.64800   1.000 42.48152 ? 10  ASP B CB  1 
ATOM   1222 C CG  . ASP B 1 10  ? -26.81600 -6.60600  2.24600   1.000 48.72714 ? 10  ASP B CG  1 
ATOM   1223 O OD1 . ASP B 1 10  ? -27.45500 -7.68600  2.31800   1.000 49.03188 ? 10  ASP B OD1 1 
ATOM   1224 O OD2 . ASP B 1 10  ? -25.64000 -6.45600  2.63900   1.000 55.62228 ? 10  ASP B OD2 1 
ATOM   1225 N N   . ARG B 1 11  ? -28.83300 -4.48500  -1.55800  1.000 36.40014 ? 11  ARG B N   1 
ATOM   1226 C CA  . ARG B 1 11  ? -29.27100 -3.26100  -2.20600  1.000 35.38834 ? 11  ARG B CA  1 
ATOM   1227 C C   . ARG B 1 11  ? -30.79000 -3.20100  -2.25200  1.000 36.95423 ? 11  ARG B C   1 
ATOM   1228 O O   . ARG B 1 11  ? -31.38300 -2.14100  -2.01200  1.000 37.45308 ? 11  ARG B O   1 
ATOM   1229 C CB  . ARG B 1 11  ? -28.67500 -3.14700  -3.61000  1.000 31.30830 ? 11  ARG B CB  1 
ATOM   1230 C CG  . ARG B 1 11  ? -29.27700 -1.99800  -4.41800  1.000 34.35031 ? 11  ARG B CG  1 
ATOM   1231 C CD  . ARG B 1 11  ? -28.79000 -0.63100  -3.92300  1.000 41.42517 ? 11  ARG B CD  1 
ATOM   1232 N NE  . ARG B 1 11  ? -29.80100 0.09000   -3.14600  1.000 50.87931 ? 11  ARG B NE  1 
ATOM   1233 C CZ  . ARG B 1 11  ? -29.70300 1.36400   -2.77900  1.000 48.48409 ? 11  ARG B CZ  1 
ATOM   1234 N NH1 . ARG B 1 11  ? -28.67400 2.11300   -3.14700  1.000 46.59129 ? 11  ARG B NH1 1 
ATOM   1235 N NH2 . ARG B 1 11  ? -30.66300 1.90100   -2.02800  1.000 50.77046 ? 11  ARG B NH2 1 
ATOM   1236 N N   . LEU B 1 12  ? -31.43600 -4.33000  -2.56000  1.000 32.72757 ? 12  LEU B N   1 
ATOM   1237 C CA  . LEU B 1 12  ? -32.89100 -4.41900  -2.61400  1.000 32.53657 ? 12  LEU B CA  1 
ATOM   1238 C C   . LEU B 1 12  ? -33.36800 -5.09900  -1.34700  1.000 31.54315 ? 12  LEU B C   1 
ATOM   1239 O O   . LEU B 1 12  ? -32.91600 -6.20300  -1.03600  1.000 32.57414 ? 12  LEU B O   1 
ATOM   1240 C CB  . LEU B 1 12  ? -33.36700 -5.21400  -3.83300  1.000 27.01132 ? 12  LEU B CB  1 
ATOM   1241 C CG  . LEU B 1 12  ? -33.06700 -4.68000  -5.23500  1.000 30.33363 ? 12  LEU B CG  1 
ATOM   1242 C CD1 . LEU B 1 12  ? -33.55000 -5.68600  -6.25700  1.000 25.36238 ? 12  LEU B CD1 1 
ATOM   1243 C CD2 . LEU B 1 12  ? -33.73300 -3.33200  -5.46100  1.000 33.74434 ? 12  LEU B CD2 1 
ATOM   1244 N N   . THR B 1 13  ? -34.28900 -4.45800  -0.63200  1.000 33.81093 ? 13  THR B N   1 
ATOM   1245 C CA  . THR B 1 13  ? -34.93800 -5.11900  0.49400   1.000 33.12346 ? 13  THR B CA  1 
ATOM   1246 C C   . THR B 1 13  ? -35.87200 -6.19200  -0.05300  1.000 30.98043 ? 13  THR B C   1 
ATOM   1247 O O   . THR B 1 13  ? -36.15400 -6.20900  -1.24900  1.000 34.00532 ? 13  THR B O   1 
ATOM   1248 C CB  . THR B 1 13  ? -35.72600 -4.11800  1.32900   1.000 29.93674 ? 13  THR B CB  1 
ATOM   1249 O OG1 . THR B 1 13  ? -36.77000 -3.59500  0.52000   1.000 31.90330 ? 13  THR B OG1 1 
ATOM   1250 C CG2 . THR B 1 13  ? -34.83000 -2.98200  1.83300   1.000 32.31911 ? 13  THR B CG2 1 
ATOM   1251 N N   . PRO B 1 14  ? -36.34000 -7.12800  0.78400   1.000 33.18362 ? 14  PRO B N   1 
ATOM   1252 C CA  . PRO B 1 14  ? -37.35300 -8.07600  0.29000   1.000 32.95849 ? 14  PRO B CA  1 
ATOM   1253 C C   . PRO B 1 14  ? -38.55700 -7.38400  -0.31300  1.000 35.33971 ? 14  PRO B C   1 
ATOM   1254 O O   . PRO B 1 14  ? -39.11600 -7.86200  -1.30900  1.000 31.03867 ? 14  PRO B O   1 
ATOM   1255 C CB  . PRO B 1 14  ? -37.72300 -8.88500  1.54000   1.000 27.55879 ? 14  PRO B CB  1 
ATOM   1256 C CG  . PRO B 1 14  ? -36.50100 -8.84300  2.37700   1.000 32.29710 ? 14  PRO B CG  1 
ATOM   1257 C CD  . PRO B 1 14  ? -35.87100 -7.48700  2.13600   1.000 30.73712 ? 14  PRO B CD  1 
ATOM   1258 N N   . SER B 1 15  ? -38.95600 -6.24400  0.24200   1.000 33.85325 ? 15  SER B N   1 
ATOM   1259 C CA  . SER B 1 15  ? -40.08700 -5.51100  -0.31700  1.000 34.76063 ? 15  SER B CA  1 
ATOM   1260 C C   . SER B 1 15  ? -39.75600 -4.95600  -1.69200  1.000 35.87873 ? 15  SER B C   1 
ATOM   1261 O O   . SER B 1 15  ? -40.63700 -4.85700  -2.55900  1.000 27.42089 ? 15  SER B O   1 
ATOM   1262 C CB  . SER B 1 15  ? -40.49900 -4.39700  0.63500   1.000 28.92792 ? 15  SER B CB  1 
ATOM   1263 O OG  . SER B 1 15  ? -41.46900 -3.56300  0.06700   1.000 40.46669 ? 15  SER B OG  1 
ATOM   1264 N N   . ALA B 1 16  ? -38.49200 -4.59900  -1.90400  1.000 35.33820 ? 16  ALA B N   1 
ATOM   1265 C CA  . ALA B 1 16  ? -38.04200 -4.08600  -3.18900  1.000 30.71218 ? 16  ALA B CA  1 
ATOM   1266 C C   . ALA B 1 16  ? -37.88400 -5.19300  -4.21300  1.000 29.59672 ? 16  ALA B C   1 
ATOM   1267 O O   . ALA B 1 16  ? -38.10500 -4.95200  -5.40300  1.000 29.51355 ? 16  ALA B O   1 
ATOM   1268 C CB  . ALA B 1 16  ? -36.71100 -3.34600  -3.03400  1.000 31.13643 ? 16  ALA B CB  1 
ATOM   1269 N N   . LYS B 1 17  ? -37.46000 -6.38500  -3.77400  1.000 35.28565 ? 17  LYS B N   1 
ATOM   1270 C CA  . LYS B 1 17  ? -37.40600 -7.53800  -4.67000  1.000 33.63056 ? 17  LYS B CA  1 
ATOM   1271 C C   . LYS B 1 17  ? -38.79000 -7.87200  -5.19200  1.000 31.83421 ? 17  LYS B C   1 
ATOM   1272 O O   . LYS B 1 17  ? -38.97800 -8.10100  -6.39300  1.000 28.58890 ? 17  LYS B O   1 
ATOM   1273 C CB  . LYS B 1 17  ? -36.81400 -8.74900  -3.94700  1.000 30.75462 ? 17  LYS B CB  1 
ATOM   1274 C CG  . LYS B 1 17  ? -35.30000 -8.73400  -3.81800  1.000 28.78190 ? 17  LYS B CG  1 
ATOM   1275 C CD  . LYS B 1 17  ? -34.80300 -9.97400  -3.07600  1.000 26.03126 ? 17  LYS B CD  1 
ATOM   1276 C CE  . LYS B 1 17  ? -33.33500 -9.82900  -2.73700  1.000 30.92614 ? 17  LYS B CE  1 
ATOM   1277 N NZ  . LYS B 1 17  ? -32.88100 -10.82900 -1.74500  1.000 31.94501 ? 17  LYS B NZ  1 
ATOM   1278 N N   . HIS B 1 18  ? -39.77700 -7.88000  -4.29800  1.000 32.47286 ? 18  HIS B N   1 
ATOM   1279 C CA  . HIS B 1 18  ? -41.14700 -8.14500  -4.71300  1.000 31.84429 ? 18  HIS B CA  1 
ATOM   1280 C C   . HIS B 1 18  ? -41.63400 -7.10100  -5.70400  1.000 29.95430 ? 18  HIS B C   1 
ATOM   1281 O O   . HIS B 1 18  ? -42.25300 -7.44000  -6.72100  1.000 29.39332 ? 18  HIS B O   1 
ATOM   1282 C CB  . HIS B 1 18  ? -42.06300 -8.18300  -3.49000  1.000 30.13337 ? 18  HIS B CB  1 
ATOM   1283 C CG  . HIS B 1 18  ? -43.26100 -9.05700  -3.66900  1.000 34.13711 ? 18  HIS B CG  1 
ATOM   1284 N ND1 . HIS B 1 18  ? -43.86600 -9.71700  -2.62100  1.000 41.71174 ? 18  HIS B ND1 1 
ATOM   1285 C CD2 . HIS B 1 18  ? -43.95100 -9.40200  -4.78200  1.000 34.93215 ? 18  HIS B CD2 1 
ATOM   1286 C CE1 . HIS B 1 18  ? -44.88200 -10.42500 -3.08100  1.000 47.87896 ? 18  HIS B CE1 1 
ATOM   1287 N NE2 . HIS B 1 18  ? -44.95800 -10.24800 -4.39000  1.000 45.57047 ? 18  HIS B NE2 1 
ATOM   1288 N N   . ALA B 1 19  ? -41.35700 -5.82400  -5.43000  1.000 28.84877 ? 19  ALA B N   1 
ATOM   1289 C CA  . ALA B 1 19  ? -41.82800 -4.75500  -6.30700  1.000 25.43973 ? 19  ALA B CA  1 
ATOM   1290 C C   . ALA B 1 19  ? -41.12700 -4.78000  -7.66500  1.000 26.96826 ? 19  ALA B C   1 
ATOM   1291 O O   . ALA B 1 19  ? -41.74500 -4.44100  -8.68500  1.000 30.89086 ? 19  ALA B O   1 
ATOM   1292 C CB  . ALA B 1 19  ? -41.63700 -3.39700  -5.62200  1.000 24.25459 ? 19  ALA B CB  1 
ATOM   1293 N N   . VAL B 1 20  ? -39.85000 -5.17600  -7.70500  1.000 24.12177 ? 20  VAL B N   1 
ATOM   1294 C CA  . VAL B 1 20  ? -39.12300 -5.24200  -8.97400  1.000 25.88901 ? 20  VAL B CA  1 
ATOM   1295 C C   . VAL B 1 20  ? -39.62700 -6.41700  -9.81300  1.000 26.07177 ? 20  VAL B C   1 
ATOM   1296 O O   . VAL B 1 20  ? -39.85700 -6.28200  -11.02100 1.000 27.87451 ? 20  VAL B O   1 
ATOM   1297 C CB  . VAL B 1 20  ? -37.60400 -5.32600  -8.71000  1.000 24.29747 ? 20  VAL B CB  1 
ATOM   1298 C CG1 . VAL B 1 20  ? -36.85500 -5.91300  -9.90600  1.000 23.33284 ? 20  VAL B CG1 1 
ATOM   1299 C CG2 . VAL B 1 20  ? -37.02100 -3.95400  -8.32500  1.000 23.33462 ? 20  VAL B CG2 1 
ATOM   1300 N N   . ALA B 1 21  ? -39.83300 -7.57300  -9.17400  1.000 24.70423 ? 21  ALA B N   1 
ATOM   1301 C CA  . ALA B 1 21  ? -40.40100 -8.73900  -9.84200  1.000 28.21725 ? 21  ALA B CA  1 
ATOM   1302 C C   . ALA B 1 21  ? -41.78500 -8.43700  -10.40700 1.000 32.21111 ? 21  ALA B C   1 
ATOM   1303 O O   . ALA B 1 21  ? -42.05000 -8.67200  -11.59400 1.000 30.97545 ? 21  ALA B O   1 
ATOM   1304 C CB  . ALA B 1 21  ? -40.47400 -9.92000  -8.86400  1.000 23.11178 ? 21  ALA B CB  1 
ATOM   1305 N N   . LYS B 1 22  ? -42.69500 -7.96400  -9.55000  1.000 25.81711 ? 22  LYS B N   1 
ATOM   1306 C CA  . LYS B 1 22  ? -44.01100 -7.51300  -9.99500  1.000 27.95330 ? 22  LYS B CA  1 
ATOM   1307 C C   . LYS B 1 22  ? -43.90800 -6.51900  -11.14500 1.000 30.68795 ? 22  LYS B C   1 
ATOM   1308 O O   . LYS B 1 22  ? -44.70000 -6.57300  -12.09400 1.000 32.14374 ? 22  LYS B O   1 
ATOM   1309 C CB  . LYS B 1 22  ? -44.76700 -6.88300  -8.81700  1.000 29.11394 ? 22  LYS B CB  1 
ATOM   1310 C CG  . LYS B 1 22  ? -46.20800 -6.44900  -9.11100  1.000 36.17704 ? 22  LYS B CG  1 
ATOM   1311 C CD  . LYS B 1 22  ? -47.23900 -7.53600  -8.74200  1.000 48.47165 ? 22  LYS B CD  1 
ATOM   1312 C CE  . LYS B 1 22  ? -48.39100 -7.63400  -9.76700  1.000 47.09147 ? 22  LYS B CE  1 
ATOM   1313 N NZ  . LYS B 1 22  ? -49.47200 -6.59600  -9.61300  1.000 45.38944 ? 22  LYS B NZ  1 
ATOM   1314 N N   . ALA B 1 23  ? -42.93900 -5.59700  -11.07600 1.000 31.98822 ? 23  ALA B N   1 
ATOM   1315 C CA  . ALA B 1 23  ? -42.80000 -4.59600  -12.13300 1.000 30.74848 ? 23  ALA B CA  1 
ATOM   1316 C C   . ALA B 1 23  ? -42.39600 -5.23400  -13.46000 1.000 28.71467 ? 23  ALA B C   1 
ATOM   1317 O O   . ALA B 1 23  ? -42.94200 -4.88600  -14.51600 1.000 29.50719 ? 23  ALA B O   1 
ATOM   1318 C CB  . ALA B 1 23  ? -41.78100 -3.53200  -11.73900 1.000 25.67539 ? 23  ALA B CB  1 
ATOM   1319 N N   . ILE B 1 24  ? -41.43900 -6.16400  -13.42700 1.000 29.60714 ? 24  ILE B N   1 
ATOM   1320 C CA  . ILE B 1 24  ? -41.02100 -6.85600  -14.64400 1.000 25.83973 ? 24  ILE B CA  1 
ATOM   1321 C C   . ILE B 1 24  ? -42.14900 -7.73000  -15.17000 1.000 24.82195 ? 24  ILE B C   1 
ATOM   1322 O O   . ILE B 1 24  ? -42.41800 -7.77200  -16.37700 1.000 27.21661 ? 24  ILE B O   1 
ATOM   1323 C CB  . ILE B 1 24  ? -39.75400 -7.68700  -14.36900 1.000 26.31292 ? 24  ILE B CB  1 
ATOM   1324 C CG1 . ILE B 1 24  ? -38.56100 -6.77000  -14.10000 1.000 24.40023 ? 24  ILE B CG1 1 
ATOM   1325 C CG2 . ILE B 1 24  ? -39.49800 -8.62400  -15.52600 1.000 20.57452 ? 24  ILE B CG2 1 
ATOM   1326 C CD1 . ILE B 1 24  ? -37.32200 -7.50800  -13.68800 1.000 21.30900 ? 24  ILE B CD1 1 
ATOM   1327 N N   . THR B 1 25  ? -42.84300 -8.41600  -14.26500 1.000 25.00221 ? 25  THR B N   1 
ATOM   1328 C CA  . THR B 1 25  ? -43.85500 -9.38900  -14.64500 1.000 25.22999 ? 25  THR B CA  1 
ATOM   1329 C C   . THR B 1 25  ? -45.09500 -8.72000  -15.22400 1.000 27.56365 ? 25  THR B C   1 
ATOM   1330 O O   . THR B 1 25  ? -45.67500 -9.22000  -16.19000 1.000 26.34576 ? 25  THR B O   1 
ATOM   1331 C CB  . THR B 1 25  ? -44.19900 -10.22700 -13.41700 1.000 27.34594 ? 25  THR B CB  1 
ATOM   1332 O OG1 . THR B 1 25  ? -43.00800 -10.87600 -12.97300 1.000 27.35227 ? 25  THR B OG1 1 
ATOM   1333 C CG2 . THR B 1 25  ? -45.27600 -11.25900 -13.72100 1.000 32.41183 ? 25  THR B CG2 1 
ATOM   1334 N N   . ASP B 1 26  ? -45.51500 -7.58600  -14.65300 1.000 28.67834 ? 26  ASP B N   1 
ATOM   1335 C CA  . ASP B 1 26  ? -46.66400 -6.84500  -15.18700 1.000 30.37231 ? 26  ASP B CA  1 
ATOM   1336 C C   . ASP B 1 26  ? -46.35100 -6.24400  -16.56000 1.000 32.14928 ? 26  ASP B C   1 
ATOM   1337 O O   . ASP B 1 26  ? -47.21900 -6.20700  -17.44500 1.000 28.45232 ? 26  ASP B O   1 
ATOM   1338 C CB  . ASP B 1 26  ? -47.07300 -5.72800  -14.21200 1.000 25.88615 ? 26  ASP B CB  1 
ATOM   1339 C CG  . ASP B 1 26  ? -47.68300 -6.25500  -12.90400 1.000 37.61705 ? 26  ASP B CG  1 
ATOM   1340 O OD1 . ASP B 1 26  ? -47.92600 -7.48000  -12.77700 1.000 32.55018 ? 26  ASP B OD1 1 
ATOM   1341 O OD2 . ASP B 1 26  ? -47.91100 -5.41800  -11.99400 1.000 29.86702 ? 26  ASP B OD2 1 
ATOM   1342 N N   . ALA B 1 27  ? -45.13700 -5.71600  -16.74200 1.000 25.06893 ? 27  ALA B N   1 
ATOM   1343 C CA  . ALA B 1 27  ? -44.76900 -5.18300  -18.05200 1.000 27.65438 ? 27  ALA B CA  1 
ATOM   1344 C C   . ALA B 1 27  ? -44.78900 -6.28000  -19.10500 1.000 27.09680 ? 27  ALA B C   1 
ATOM   1345 O O   . ALA B 1 27  ? -45.29200 -6.08000  -20.21800 1.000 24.61336 ? 27  ALA B O   1 
ATOM   1346 C CB  . ALA B 1 27  ? -43.39500 -4.53400  -17.99500 1.000 24.17604 ? 27  ALA B CB  1 
ATOM   1347 N N   . HIS B 1 28  ? -44.26600 -7.46000  -18.75500 1.000 27.60847 ? 28  HIS B N   1 
ATOM   1348 C CA  . HIS B 1 28  ? -44.21500 -8.56500  -19.70500 1.000 28.45988 ? 28  HIS B CA  1 
ATOM   1349 C C   . HIS B 1 28  ? -45.61300 -9.04600  -20.07100 1.000 27.45752 ? 28  HIS B C   1 
ATOM   1350 O O   . HIS B 1 28  ? -45.91700 -9.25900  -21.25100 1.000 27.91168 ? 28  HIS B O   1 
ATOM   1351 C CB  . HIS B 1 28  ? -43.38500 -9.71100  -19.13200 1.000 26.35942 ? 28  HIS B CB  1 
ATOM   1352 C CG  . HIS B 1 28  ? -42.97400 -10.69400 -20.17200 1.000 31.55825 ? 28  HIS B CG  1 
ATOM   1353 N ND1 . HIS B 1 28  ? -41.81600 -10.55300 -20.90900 1.000 29.60340 ? 28  HIS B ND1 1 
ATOM   1354 C CD2 . HIS B 1 28  ? -43.59200 -11.80200 -20.64200 1.000 25.32588 ? 28  HIS B CD2 1 
ATOM   1355 C CE1 . HIS B 1 28  ? -41.72800 -11.54700 -21.77200 1.000 29.38751 ? 28  HIS B CE1 1 
ATOM   1356 N NE2 . HIS B 1 28  ? -42.79300 -12.31800 -21.63100 1.000 33.07800 ? 28  HIS B NE2 1 
ATOM   1357 N N   . ARG B 1 29  ? -46.47400 -9.22700  -19.06400 1.000 30.23470 ? 29  ARG B N   1 
ATOM   1358 C CA  . ARG B 1 29  ? -47.86800 -9.58800  -19.30900 1.000 34.60754 ? 29  ARG B CA  1 
ATOM   1359 C C   . ARG B 1 29  ? -48.59700 -8.49800  -20.08100 1.000 31.76217 ? 29  ARG B C   1 
ATOM   1360 O O   . ARG B 1 29  ? -49.34800 -8.78900  -21.01700 1.000 32.90355 ? 29  ARG B O   1 
ATOM   1361 C CB  . ARG B 1 29  ? -48.58500 -9.84700  -17.98400 1.000 34.84091 ? 29  ARG B CB  1 
ATOM   1362 C CG  . ARG B 1 29  ? -49.73500 -10.84000 -18.07500 1.000 41.34163 ? 29  ARG B CG  1 
ATOM   1363 C CD  . ARG B 1 29  ? -51.01100 -10.25700 -18.65400 1.000 43.98522 ? 29  ARG B CD  1 
ATOM   1364 N NE  . ARG B 1 29  ? -52.12800 -11.19500 -18.55200 1.000 50.16757 ? 29  ARG B NE  1 
ATOM   1365 C CZ  . ARG B 1 29  ? -53.02100 -11.39600 -19.50800 1.000 45.29536 ? 29  ARG B CZ  1 
ATOM   1366 N NH1 . ARG B 1 29  ? -52.97200 -10.72000 -20.64400 1.000 45.47217 ? 29  ARG B NH1 1 
ATOM   1367 N NH2 . ARG B 1 29  ? -53.98300 -12.29700 -19.32100 1.000 48.47001 ? 29  ARG B NH2 1 
ATOM   1368 N N   . GLY B 1 30  ? -48.40300 -7.24300  -19.69400 1.000 28.73651 ? 30  GLY B N   1 
ATOM   1369 C CA  . GLY B 1 30  ? -49.14100 -6.16800  -20.32300 1.000 30.98433 ? 30  GLY B CA  1 
ATOM   1370 C C   . GLY B 1 30  ? -48.81600 -6.01500  -21.79400 1.000 35.24126 ? 30  GLY B C   1 
ATOM   1371 O O   . GLY B 1 30  ? -49.69400 -5.68100  -22.59700 1.000 30.05685 ? 30  GLY B O   1 
ATOM   1372 N N   . LEU B 1 31  ? -47.56200 -6.26400  -22.17200 1.000 28.57554 ? 31  LEU B N   1 
ATOM   1373 C CA  . LEU B 1 31  ? -47.14300 -6.03800  -23.54900 1.000 32.28931 ? 31  LEU B CA  1 
ATOM   1374 C C   . LEU B 1 31  ? -47.17700 -7.29500  -24.41400 1.000 32.44321 ? 31  LEU B C   1 
ATOM   1375 O O   . LEU B 1 31  ? -47.31200 -7.18100  -25.63300 1.000 30.36354 ? 31  LEU B O   1 
ATOM   1376 C CB  . LEU B 1 31  ? -45.73200 -5.42400  -23.57600 1.000 27.68311 ? 31  LEU B CB  1 
ATOM   1377 C CG  . LEU B 1 31  ? -45.83000 -3.92700  -23.23300 1.000 38.09930 ? 31  LEU B CG  1 
ATOM   1378 C CD1 . LEU B 1 31  ? -44.52000 -3.40600  -22.69500 1.000 31.36382 ? 31  LEU B CD1 1 
ATOM   1379 C CD2 . LEU B 1 31  ? -46.29800 -3.10200  -24.45900 1.000 34.95637 ? 31  LEU B CD2 1 
ATOM   1380 N N   . THR B 1 32  ? -47.06700 -8.49400  -23.82600 1.000 30.07652 ? 32  THR B N   1 
ATOM   1381 C CA  . THR B 1 32  ? -47.03100 -9.71400  -24.61800 1.000 29.69299 ? 32  THR B CA  1 
ATOM   1382 C C   . THR B 1 32  ? -48.28000 -10.57200 -24.49600 1.000 30.05064 ? 32  THR B C   1 
ATOM   1383 O O   . THR B 1 32  ? -48.53600 -11.37500 -25.39700 1.000 30.06290 ? 32  THR B O   1 
ATOM   1384 C CB  . THR B 1 32  ? -45.81800 -10.58400 -24.24300 1.000 31.45549 ? 32  THR B CB  1 
ATOM   1385 O OG1 . THR B 1 32  ? -45.95100 -11.05500 -22.89400 1.000 30.59749 ? 32  THR B OG1 1 
ATOM   1386 C CG2 . THR B 1 32  ? -44.51200 -9.80800  -24.39800 1.000 31.70980 ? 32  THR B CG2 1 
ATOM   1387 N N   . GLY B 1 33  ? -49.05300 -10.43600 -23.41400 1.000 32.56767 ? 33  GLY B N   1 
ATOM   1388 C CA  . GLY B 1 33  ? -50.19000 -11.29500 -23.17400 1.000 32.70793 ? 33  GLY B CA  1 
ATOM   1389 C C   . GLY B 1 33  ? -49.86700 -12.60600 -22.49200 1.000 32.33442 ? 33  GLY B C   1 
ATOM   1390 O O   . GLY B 1 33  ? -50.79400 -13.32200 -22.08300 1.000 30.40705 ? 33  GLY B O   1 
ATOM   1391 N N   . THR B 1 34  ? -48.58800 -12.95600 -22.37100 1.000 31.88405 ? 34  THR B N   1 
ATOM   1392 C CA  . THR B 1 34  ? -48.18000 -14.14700 -21.64600 1.000 27.61880 ? 34  THR B CA  1 
ATOM   1393 C C   . THR B 1 34  ? -48.69000 -14.10000 -20.21500 1.000 33.11544 ? 34  THR B C   1 
ATOM   1394 O O   . THR B 1 34  ? -48.54700 -13.08300 -19.53800 1.000 32.03873 ? 34  THR B O   1 
ATOM   1395 C CB  . THR B 1 34  ? -46.66500 -14.23400 -21.63200 1.000 29.18243 ? 34  THR B CB  1 
ATOM   1396 O OG1 . THR B 1 34  ? -46.20000 -14.49400 -22.96100 1.000 35.04277 ? 34  THR B OG1 1 
ATOM   1397 C CG2 . THR B 1 34  ? -46.21400 -15.32600 -20.69700 1.000 24.91854 ? 34  THR B CG2 1 
ATOM   1398 N N   . GLN B 1 35  ? -49.26800 -15.21100 -19.75400 1.000 32.65112 ? 35  GLN B N   1 
ATOM   1399 C CA  . GLN B 1 35  ? -49.82900 -15.30200 -18.40900 1.000 32.03185 ? 35  GLN B CA  1 
ATOM   1400 C C   . GLN B 1 35  ? -48.74900 -15.08300 -17.35800 1.000 34.67943 ? 35  GLN B C   1 
ATOM   1401 O O   . GLN B 1 35  ? -47.61800 -15.55400 -17.50000 1.000 33.11459 ? 35  GLN B O   1 
ATOM   1402 C CB  . GLN B 1 35  ? -50.46300 -16.68300 -18.20500 1.000 36.86522 ? 35  GLN B CB  1 
ATOM   1403 C CG  . GLN B 1 35  ? -51.58600 -17.01900 -19.17100 1.000 35.16353 ? 35  GLN B CG  1 
ATOM   1404 C CD  . GLN B 1 35  ? -51.13100 -17.99000 -20.24200 1.000 35.45375 ? 35  GLN B CD  1 
ATOM   1405 O OE1 . GLN B 1 35  ? -49.96700 -17.98500 -20.63200 1.000 36.50096 ? 35  GLN B OE1 1 
ATOM   1406 N NE2 . GLN B 1 35  ? -52.04800 -18.81900 -20.72800 1.000 39.03665 ? 35  GLN B NE2 1 
ATOM   1407 N N   . HIS B 1 36  ? -49.11800 -14.37400 -16.29300 1.000 30.53763 ? 36  HIS B N   1 
ATOM   1408 C CA  . HIS B 1 36  ? -48.22500 -14.11400 -15.16900 1.000 31.33848 ? 36  HIS B CA  1 
ATOM   1409 C C   . HIS B 1 36  ? -47.36200 -15.31900 -14.78000 1.000 34.75772 ? 36  HIS B C   1 
ATOM   1410 O O   . HIS B 1 36  ? -46.12600 -15.22400 -14.73100 1.000 27.72936 ? 36  HIS B O   1 
ATOM   1411 C CB  . HIS B 1 36  ? -49.06400 -13.66400 -13.97100 1.000 37.65914 ? 36  HIS B CB  1 
ATOM   1412 C CG  . HIS B 1 36  ? -49.25400 -12.18400 -13.89800 1.000 37.33535 ? 36  HIS B CG  1 
ATOM   1413 N ND1 . HIS B 1 36  ? -50.17200 -11.51800 -14.68100 1.000 39.22822 ? 36  HIS B ND1 1 
ATOM   1414 C CD2 . HIS B 1 36  ? -48.63500 -11.24000 -13.15000 1.000 37.46802 ? 36  HIS B CD2 1 
ATOM   1415 C CE1 . HIS B 1 36  ? -50.10900 -10.22500 -14.41700 1.000 41.11340 ? 36  HIS B CE1 1 
ATOM   1416 N NE2 . HIS B 1 36  ? -49.18300 -10.03000 -13.49400 1.000 41.72518 ? 36  HIS B NE2 1 
ATOM   1417 N N   . PHE B 1 37  ? -47.99800 -16.47100 -14.52100 1.000 30.66062 ? 37  PHE B N   1 
ATOM   1418 C CA  . PHE B 1 37  ? -47.28700 -17.62500 -13.97700 1.000 33.61539 ? 37  PHE B CA  1 
ATOM   1419 C C   . PHE B 1 37  ? -46.18700 -18.15300 -14.89800 1.000 30.99835 ? 37  PHE B C   1 
ATOM   1420 O O   . PHE B 1 37  ? -45.36100 -18.95800 -14.44800 1.000 32.76851 ? 37  PHE B O   1 
ATOM   1421 C CB  . PHE B 1 37  ? -48.26600 -18.77600 -13.64800 1.000 32.94765 ? 37  PHE B CB  1 
ATOM   1422 C CG  . PHE B 1 37  ? -49.30800 -19.04800 -14.71700 1.000 33.18496 ? 37  PHE B CG  1 
ATOM   1423 C CD1 . PHE B 1 37  ? -48.99300 -19.79000 -15.85100 1.000 34.40669 ? 37  PHE B CD1 1 
ATOM   1424 C CD2 . PHE B 1 37  ? -50.60800 -18.60200 -14.56200 1.000 29.87528 ? 37  PHE B CD2 1 
ATOM   1425 C CE1 . PHE B 1 37  ? -49.96600 -20.05800 -16.82900 1.000 35.32546 ? 37  PHE B CE1 1 
ATOM   1426 C CE2 . PHE B 1 37  ? -51.56900 -18.85100 -15.52500 1.000 32.58037 ? 37  PHE B CE2 1 
ATOM   1427 C CZ  . PHE B 1 37  ? -51.25500 -19.57700 -16.65700 1.000 35.42602 ? 37  PHE B CZ  1 
ATOM   1428 N N   . LEU B 1 38  ? -46.14600 -17.73600 -16.16300 1.000 28.54474 ? 38  LEU B N   1 
ATOM   1429 C CA  . LEU B 1 38  ? -45.08200 -18.16900 -17.06500 1.000 32.28476 ? 38  LEU B CA  1 
ATOM   1430 C C   . LEU B 1 38  ? -43.84000 -17.29400 -16.99100 1.000 29.05750 ? 38  LEU B C   1 
ATOM   1431 O O   . LEU B 1 38  ? -42.83800 -17.63400 -17.62300 1.000 31.69262 ? 38  LEU B O   1 
ATOM   1432 C CB  . LEU B 1 38  ? -45.58000 -18.20600 -18.51600 1.000 29.64534 ? 38  LEU B CB  1 
ATOM   1433 C CG  . LEU B 1 38  ? -46.53200 -19.36900 -18.80500 1.000 31.31493 ? 38  LEU B CG  1 
ATOM   1434 C CD1 . LEU B 1 38  ? -47.11900 -19.27900 -20.20900 1.000 27.60361 ? 38  LEU B CD1 1 
ATOM   1435 C CD2 . LEU B 1 38  ? -45.81000 -20.69400 -18.60200 1.000 31.54018 ? 38  LEU B CD2 1 
ATOM   1436 N N   . ALA B 1 39  ? -43.87200 -16.18500 -16.24100 1.000 27.29822 ? 39  ALA B N   1 
ATOM   1437 C CA  . ALA B 1 39  ? -42.76200 -15.23900 -16.18700 1.000 28.08968 ? 39  ALA B CA  1 
ATOM   1438 C C   . ALA B 1 39  ? -42.02500 -15.39000 -14.86000 1.000 26.32975 ? 39  ALA B C   1 
ATOM   1439 O O   . ALA B 1 39  ? -42.58200 -15.09600 -13.79600 1.000 27.39028 ? 39  ALA B O   1 
ATOM   1440 C CB  . ALA B 1 39  ? -43.26300 -13.81400 -16.38700 1.000 26.94761 ? 39  ALA B CB  1 
ATOM   1441 N N   . GLN B 1 40  ? -40.76800 -15.83100 -14.93700 1.000 23.17462 ? 40  GLN B N   1 
ATOM   1442 C CA  . GLN B 1 40  ? -39.89700 -16.01100 -13.78500 1.000 23.54049 ? 40  GLN B CA  1 
ATOM   1443 C C   . GLN B 1 40  ? -38.94600 -14.82800 -13.65400 1.000 27.80048 ? 40  GLN B C   1 
ATOM   1444 O O   . GLN B 1 40  ? -38.30400 -14.42400 -14.63900 1.000 25.78552 ? 40  GLN B O   1 
ATOM   1445 C CB  . GLN B 1 40  ? -39.09100 -17.31200 -13.91000 1.000 25.79635 ? 40  GLN B CB  1 
ATOM   1446 C CG  . GLN B 1 40  ? -37.99400 -17.47100 -12.85300 1.000 28.53382 ? 40  GLN B CG  1 
ATOM   1447 C CD  . GLN B 1 40  ? -37.28200 -18.83100 -12.88000 1.000 26.80487 ? 40  GLN B CD  1 
ATOM   1448 O OE1 . GLN B 1 40  ? -36.20300 -18.98600 -12.29300 1.000 22.80366 ? 40  GLN B OE1 1 
ATOM   1449 N NE2 . GLN B 1 40  ? -37.88400 -19.81500 -13.55100 1.000 23.19338 ? 40  GLN B NE2 1 
ATOM   1450 N N   . VAL B 1 41  ? -38.84300 -14.29200 -12.43900 1.000 25.39638 ? 41  VAL B N   1 
ATOM   1451 C CA  . VAL B 1 41  ? -37.82500 -13.30600 -12.08900 1.000 24.10945 ? 41  VAL B CA  1 
ATOM   1452 C C   . VAL B 1 41  ? -36.88000 -13.94900 -11.08300 1.000 24.69941 ? 41  VAL B C   1 
ATOM   1453 O O   . VAL B 1 41  ? -37.29000 -14.31800 -9.97300  1.000 28.39328 ? 41  VAL B O   1 
ATOM   1454 C CB  . VAL B 1 41  ? -38.44100 -12.00500 -11.53400 1.000 22.55001 ? 41  VAL B CB  1 
ATOM   1455 C CG1 . VAL B 1 41  ? -37.33900 -11.04400 -11.07600 1.000 19.93873 ? 41  VAL B CG1 1 
ATOM   1456 C CG2 . VAL B 1 41  ? -39.29700 -11.32300 -12.58700 1.000 20.88999 ? 41  VAL B CG2 1 
ATOM   1457 N N   . ASN B 1 42  ? -35.61100 -14.06000 -11.45800 1.000 21.36540 ? 42  ASN B N   1 
ATOM   1458 C CA  . ASN B 1 42  ? -34.61300 -14.77700 -10.67600 1.000 21.51855 ? 42  ASN B CA  1 
ATOM   1459 C C   . ASN B 1 42  ? -33.48800 -13.81100 -10.30000 1.000 29.05560 ? 42  ASN B C   1 
ATOM   1460 O O   . ASN B 1 42  ? -32.72700 -13.34700 -11.16600 1.000 25.34880 ? 42  ASN B O   1 
ATOM   1461 C CB  . ASN B 1 42  ? -34.09200 -15.97800 -11.45500 1.000 22.57903 ? 42  ASN B CB  1 
ATOM   1462 C CG  . ASN B 1 42  ? -33.41400 -16.99800 -10.56500 1.000 27.02863 ? 42  ASN B CG  1 
ATOM   1463 O OD1 . ASN B 1 42  ? -32.63100 -16.64400 -9.66800  1.000 28.82563 ? 42  ASN B OD1 1 
ATOM   1464 N ND2 . ASN B 1 42  ? -33.69900 -18.27400 -10.80900 1.000 19.42240 ? 42  ASN B ND2 1 
ATOM   1465 N N   . PHE B 1 43  ? -33.39200 -13.50000 -9.00500  1.000 24.11605 ? 43  PHE B N   1 
ATOM   1466 C CA  . PHE B 1 43  ? -32.43100 -12.52400 -8.49800  1.000 25.08410 ? 43  PHE B CA  1 
ATOM   1467 C C   . PHE B 1 43  ? -31.12300 -13.21800 -8.17400  1.000 21.31387 ? 43  PHE B C   1 
ATOM   1468 O O   . PHE B 1 43  ? -31.10400 -14.20500 -7.42700  1.000 26.51436 ? 43  PHE B O   1 
ATOM   1469 C CB  . PHE B 1 43  ? -32.95500 -11.81700 -7.24500  1.000 26.73737 ? 43  PHE B CB  1 
ATOM   1470 C CG  . PHE B 1 43  ? -34.00800 -10.81000 -7.52000  1.000 23.27355 ? 43  PHE B CG  1 
ATOM   1471 C CD1 . PHE B 1 43  ? -33.67800 -9.54600  -7.95900  1.000 24.23476 ? 43  PHE B CD1 1 
ATOM   1472 C CD2 . PHE B 1 43  ? -35.33800 -11.12600 -7.32700  1.000 24.02812 ? 43  PHE B CD2 1 
ATOM   1473 C CE1 . PHE B 1 43  ? -34.65700 -8.61000  -8.21200  1.000 22.21647 ? 43  PHE B CE1 1 
ATOM   1474 C CE2 . PHE B 1 43  ? -36.32200 -10.19800 -7.58100  1.000 25.23365 ? 43  PHE B CE2 1 
ATOM   1475 C CZ  . PHE B 1 43  ? -35.97900 -8.93800  -8.03600  1.000 23.38080 ? 43  PHE B CZ  1 
ATOM   1476 N N   . GLN B 1 44  ? -30.03700 -12.68200 -8.71300  1.000 23.66966 ? 44  GLN B N   1 
ATOM   1477 C CA  . GLN B 1 44  ? -28.69300 -13.19900 -8.49600  1.000 25.79391 ? 44  GLN B CA  1 
ATOM   1478 C C   . GLN B 1 44  ? -27.93300 -12.10900 -7.74900  1.000 25.21814 ? 44  GLN B C   1 
ATOM   1479 O O   . GLN B 1 44  ? -27.49700 -11.12900 -8.36200  1.000 26.87642 ? 44  GLN B O   1 
ATOM   1480 C CB  . GLN B 1 44  ? -28.03300 -13.53500 -9.83200  1.000 26.69784 ? 44  GLN B CB  1 
ATOM   1481 C CG  . GLN B 1 44  ? -28.77200 -14.62800 -10.60900 1.000 23.34202 ? 44  GLN B CG  1 
ATOM   1482 C CD  . GLN B 1 44  ? -28.58500 -16.01900 -10.00000 1.000 30.19014 ? 44  GLN B CD  1 
ATOM   1483 O OE1 . GLN B 1 44  ? -27.45000 -16.47000 -9.79600  1.000 33.09316 ? 44  GLN B OE1 1 
ATOM   1484 N NE2 . GLN B 1 44  ? -29.69100 -16.69600 -9.70100  1.000 24.97971 ? 44  GLN B NE2 1 
ATOM   1485 N N   . GLU B 1 45  ? -27.79100 -12.25900 -6.42900  1.000 27.60315 ? 45  GLU B N   1 
ATOM   1486 C CA  . GLU B 1 45  ? -27.11700 -11.25400 -5.60700  1.000 26.72911 ? 45  GLU B CA  1 
ATOM   1487 C C   . GLU B 1 45  ? -25.63400 -11.57100 -5.44300  1.000 27.64201 ? 45  GLU B C   1 
ATOM   1488 O O   . GLU B 1 45  ? -25.24500 -12.72600 -5.23900  1.000 24.86721 ? 45  GLU B O   1 
ATOM   1489 C CB  . GLU B 1 45  ? -27.78900 -11.14300 -4.23900  1.000 27.61750 ? 45  GLU B CB  1 
ATOM   1490 C CG  . GLU B 1 45  ? -29.09500 -10.35900 -4.31400  1.000 32.08482 ? 45  GLU B CG  1 
ATOM   1491 C CD  . GLU B 1 45  ? -29.86600 -10.38700 -3.01500  1.000 37.02385 ? 45  GLU B CD  1 
ATOM   1492 O OE1 . GLU B 1 45  ? -30.13800 -11.50000 -2.52700  1.000 34.92938 ? 45  GLU B OE1 1 
ATOM   1493 O OE2 . GLU B 1 45  ? -30.22200 -9.29900  -2.50300  1.000 43.64734 ? 45  GLU B OE2 1 
ATOM   1494 N N   . GLN B 1 46  ? -24.80900 -10.53300 -5.54500  1.000 26.47720 ? 46  GLN B N   1 
ATOM   1495 C CA  . GLN B 1 46  ? -23.37600 -10.64300 -5.35100  1.000 27.44056 ? 46  GLN B CA  1 
ATOM   1496 C C   . GLN B 1 46  ? -22.93500 -9.49000  -4.46400  1.000 30.53718 ? 46  GLN B C   1 
ATOM   1497 O O   . GLN B 1 46  ? -23.59000 -8.44500  -4.45000  1.000 34.29590 ? 46  GLN B O   1 
ATOM   1498 C CB  . GLN B 1 46  ? -22.60400 -10.61600 -6.68300  1.000 23.08519 ? 46  GLN B CB  1 
ATOM   1499 C CG  . GLN B 1 46  ? -22.75900 -11.87000 -7.54000  1.000 25.41604 ? 46  GLN B CG  1 
ATOM   1500 C CD  . GLN B 1 46  ? -22.01200 -13.07800 -6.98500  1.000 27.36611 ? 46  GLN B CD  1 
ATOM   1501 O OE1 . GLN B 1 46  ? -20.88800 -12.95500 -6.50200  1.000 26.99207 ? 46  GLN B OE1 1 
ATOM   1502 N NE2 . GLN B 1 46  ? -22.63600 -14.24900 -7.05400  1.000 26.46345 ? 46  GLN B NE2 1 
ATOM   1503 N N   . PRO B 1 47  ? -21.84200 -9.64600  -3.70900  1.000 31.78970 ? 47  PRO B N   1 
ATOM   1504 C CA  . PRO B 1 47  ? -21.37400 -8.53000  -2.88100  1.000 31.31810 ? 47  PRO B CA  1 
ATOM   1505 C C   . PRO B 1 47  ? -21.09900 -7.29900  -3.73000  1.000 32.55990 ? 47  PRO B C   1 
ATOM   1506 O O   . PRO B 1 47  ? -20.62600 -7.39200  -4.86700  1.000 26.18765 ? 47  PRO B O   1 
ATOM   1507 C CB  . PRO B 1 47  ? -20.09100 -9.07100  -2.24000  1.000 31.18294 ? 47  PRO B CB  1 
ATOM   1508 C CG  . PRO B 1 47  ? -19.63900 -10.15800 -3.15900  1.000 32.25636 ? 47  PRO B CG  1 
ATOM   1509 C CD  . PRO B 1 47  ? -20.90200 -10.78800 -3.66500  1.000 32.05810 ? 47  PRO B CD  1 
ATOM   1510 N N   . ALA B 1 48  ? -21.42200 -6.13800  -3.16400  1.000 34.72207 ? 48  ALA B N   1 
ATOM   1511 C CA  . ALA B 1 48  ? -21.12000 -4.87700  -3.82000  1.000 33.37336 ? 48  ALA B CA  1 
ATOM   1512 C C   . ALA B 1 48  ? -19.62500 -4.78500  -4.10800  1.000 30.29540 ? 48  ALA B C   1 
ATOM   1513 O O   . ALA B 1 48  ? -18.79300 -5.21000  -3.30700  1.000 29.83557 ? 48  ALA B O   1 
ATOM   1514 C CB  . ALA B 1 48  ? -21.57900 -3.71500  -2.94000  1.000 31.05419 ? 48  ALA B CB  1 
ATOM   1515 N N   . GLY B 1 49  ? -19.28500 -4.23200  -5.26200  1.000 27.82991 ? 49  GLY B N   1 
ATOM   1516 C CA  . GLY B 1 49  ? -17.90700 -4.16200  -5.68200  1.000 27.26881 ? 49  GLY B CA  1 
ATOM   1517 C C   . GLY B 1 49  ? -17.52900 -5.20900  -6.69100  1.000 27.64688 ? 49  GLY B C   1 
ATOM   1518 O O   . GLY B 1 49  ? -16.38400 -5.20800  -7.16700  1.000 32.38875 ? 49  GLY B O   1 
ATOM   1519 N N   . ASN B 1 50  ? -18.44600 -6.11200  -7.01700  1.000 25.96115 ? 50  ASN B N   1 
ATOM   1520 C CA  . ASN B 1 50  ? -18.23300 -7.10700  -8.05900  1.000 28.48297 ? 50  ASN B CA  1 
ATOM   1521 C C   . ASN B 1 50  ? -18.57700 -6.59000  -9.45600  1.000 27.20861 ? 50  ASN B C   1 
ATOM   1522 O O   . ASN B 1 50  ? -18.29300 -7.28300  -10.44000 1.000 28.62249 ? 50  ASN B O   1 
ATOM   1523 C CB  . ASN B 1 50  ? -19.05000 -8.38700  -7.76800  1.000 24.51382 ? 50  ASN B CB  1 
ATOM   1524 C CG  . ASN B 1 50  ? -18.28600 -9.39600  -6.91900  1.000 32.48908 ? 50  ASN B CG  1 
ATOM   1525 O OD1 . ASN B 1 50  ? -17.32500 -9.05300  -6.23700  1.000 31.07312 ? 50  ASN B OD1 1 
ATOM   1526 N ND2 . ASN B 1 50  ? -18.71600 -10.64700 -6.95600  1.000 33.09597 ? 50  ASN B ND2 1 
ATOM   1527 N N   . VAL B 1 51  ? -19.15700 -5.39900  -9.58900  1.000 24.91910 ? 51  VAL B N   1 
ATOM   1528 C CA  . VAL B 1 51  ? -19.46100 -4.84100  -10.90500 1.000 26.33825 ? 51  VAL B CA  1 
ATOM   1529 C C   . VAL B 1 51  ? -18.44500 -3.76000  -11.24300 1.000 27.53461 ? 51  VAL B C   1 
ATOM   1530 O O   . VAL B 1 51  ? -18.22100 -2.83600  -10.45100 1.000 29.07062 ? 51  VAL B O   1 
ATOM   1531 C CB  . VAL B 1 51  ? -20.88700 -4.27400  -10.98300 1.000 26.65930 ? 51  VAL B CB  1 
ATOM   1532 C CG1 . VAL B 1 51  ? -21.14700 -3.78200  -12.39300 1.000 26.73489 ? 51  VAL B CG1 1 
ATOM   1533 C CG2 . VAL B 1 51  ? -21.93500 -5.31200  -10.57800 1.000 25.24428 ? 51  VAL B CG2 1 
ATOM   1534 N N   . PHE B 1 52  ? -17.83200 -3.87700  -12.42000 1.000 25.37057 ? 52  PHE B N   1 
ATOM   1535 C CA  . PHE B 1 52  ? -16.91700 -2.87500  -12.94500 1.000 27.07048 ? 52  PHE B CA  1 
ATOM   1536 C C   . PHE B 1 52  ? -17.51300 -2.30500  -14.22000 1.000 26.29851 ? 52  PHE B C   1 
ATOM   1537 O O   . PHE B 1 52  ? -17.97900 -3.05600  -15.08100 1.000 23.33753 ? 52  PHE B O   1 
ATOM   1538 C CB  . PHE B 1 52  ? -15.52500 -3.47000  -13.23000 1.000 27.06073 ? 52  PHE B CB  1 
ATOM   1539 C CG  . PHE B 1 52  ? -14.79400 -3.91500  -11.98500 1.000 32.19610 ? 52  PHE B CG  1 
ATOM   1540 C CD1 . PHE B 1 52  ? -15.20800 -5.04700  -11.28300 1.000 29.13096 ? 52  PHE B CD1 1 
ATOM   1541 C CD2 . PHE B 1 52  ? -13.70000 -3.20700  -11.51300 1.000 31.10589 ? 52  PHE B CD2 1 
ATOM   1542 C CE1 . PHE B 1 52  ? -14.53500 -5.46200  -10.11900 1.000 34.64735 ? 52  PHE B CE1 1 
ATOM   1543 C CE2 . PHE B 1 52  ? -13.03500 -3.61000  -10.35200 1.000 34.69562 ? 52  PHE B CE2 1 
ATOM   1544 C CZ  . PHE B 1 52  ? -13.44700 -4.73700  -9.65700  1.000 32.20923 ? 52  PHE B CZ  1 
ATOM   1545 N N   . LEU B 1 53  ? -17.52000 -0.98000  -14.32500 1.000 30.33198 ? 53  LEU B N   1 
ATOM   1546 C CA  . LEU B 1 53  ? -17.91400 -0.26200  -15.53200 1.000 29.47131 ? 53  LEU B CA  1 
ATOM   1547 C C   . LEU B 1 53  ? -16.69600 0.49300   -16.02400 1.000 28.97325 ? 53  LEU B C   1 
ATOM   1548 O O   . LEU B 1 53  ? -16.10600 1.27400   -15.27300 1.000 30.94798 ? 53  LEU B O   1 
ATOM   1549 C CB  . LEU B 1 53  ? -19.08500 0.70100   -15.28100 1.000 24.64770 ? 53  LEU B CB  1 
ATOM   1550 C CG  . LEU B 1 53  ? -20.31900 0.10700   -14.58400 1.000 31.82712 ? 53  LEU B CG  1 
ATOM   1551 C CD1 . LEU B 1 53  ? -21.43000 1.12700   -14.46700 1.000 29.27758 ? 53  LEU B CD1 1 
ATOM   1552 C CD2 . LEU B 1 53  ? -20.82800 -1.12000  -15.35200 1.000 27.14512 ? 53  LEU B CD2 1 
ATOM   1553 N N   . GLY B 1 54  ? -16.31100 0.24800   -17.26700 1.000 25.26857 ? 54  GLY B N   1 
ATOM   1554 C CA  . GLY B 1 54  ? -15.08800 0.82100   -17.79100 1.000 31.31537 ? 54  GLY B CA  1 
ATOM   1555 C C   . GLY B 1 54  ? -13.88000 0.58500   -16.90300 1.000 31.77216 ? 54  GLY B C   1 
ATOM   1556 O O   . GLY B 1 54  ? -12.96600 1.41100   -16.85800 1.000 35.58436 ? 54  GLY B O   1 
ATOM   1557 N N   . GLY B 1 55  ? -13.86400 -0.54500  -16.19700 1.000 29.33309 ? 55  GLY B N   1 
ATOM   1558 C CA  . GLY B 1 55  ? -12.75700 -0.88800  -15.32500 1.000 36.47774 ? 55  GLY B CA  1 
ATOM   1559 C C   . GLY B 1 55  ? -12.77600 -0.24300  -13.95300 1.000 37.58386 ? 55  GLY B C   1 
ATOM   1560 O O   . GLY B 1 55  ? -11.79100 -0.36500  -13.21600 1.000 36.55455 ? 55  GLY B O   1 
ATOM   1561 N N   . VAL B 1 56  ? -13.85400 0.44000   -13.58700 1.000 29.69400 ? 56  VAL B N   1 
ATOM   1562 C CA  . VAL B 1 56  ? -13.93200 1.20000   -12.34500 1.000 33.01635 ? 56  VAL B CA  1 
ATOM   1563 C C   . VAL B 1 56  ? -14.91400 0.47000   -11.45200 1.000 31.60300 ? 56  VAL B C   1 
ATOM   1564 O O   . VAL B 1 56  ? -16.08600 0.31200   -11.81900 1.000 33.44399 ? 56  VAL B O   1 
ATOM   1565 C CB  . VAL B 1 56  ? -14.40600 2.64400   -12.59100 1.000 36.98691 ? 56  VAL B CB  1 
ATOM   1566 C CG1 . VAL B 1 56  ? -14.94300 3.26400   -11.29500 1.000 33.48791 ? 56  VAL B CG1 1 
ATOM   1567 C CG2 . VAL B 1 56  ? -13.31300 3.49000   -13.23600 1.000 36.83389 ? 56  VAL B CG2 1 
ATOM   1568 N N   . GLN B 1 57  ? -14.45800 0.04000   -10.28100 1.000 32.66188 ? 57  GLN B N   1 
ATOM   1569 C CA  . GLN B 1 57  ? -15.33300 -0.71200  -9.38200  1.000 33.63850 ? 57  GLN B CA  1 
ATOM   1570 C C   . GLN B 1 57  ? -16.52400 0.13000   -8.92600  1.000 34.55809 ? 57  GLN B C   1 
ATOM   1571 O O   . GLN B 1 57  ? -16.36300 1.28000   -8.51900  1.000 31.86483 ? 57  GLN B O   1 
ATOM   1572 C CB  . GLN B 1 57  ? -14.54800 -1.20300  -8.17300  1.000 27.77079 ? 57  GLN B CB  1 
ATOM   1573 C CG  . GLN B 1 57  ? -15.35200 -2.15100  -7.28700  1.000 27.00098 ? 57  GLN B CG  1 
ATOM   1574 C CD  . GLN B 1 57  ? -14.54200 -2.63800  -6.10300  1.000 36.97832 ? 57  GLN B CD  1 
ATOM   1575 O OE1 . GLN B 1 57  ? -13.93900 -1.84200  -5.37800  1.000 42.31824 ? 57  GLN B OE1 1 
ATOM   1576 N NE2 . GLN B 1 57  ? -14.49700 -3.94900  -5.91600  1.000 34.44004 ? 57  GLN B NE2 1 
ATOM   1577 N N   . GLN B 1 58  ? -17.72200 -0.45000  -8.99300  1.000 33.36382 ? 58  GLN B N   1 
ATOM   1578 C CA  . GLN B 1 58  ? -18.96200 0.22900   -8.62800  1.000 33.43030 ? 58  GLN B CA  1 
ATOM   1579 C C   . GLN B 1 58  ? -19.35200 -0.05600  -7.18100  1.000 30.24281 ? 58  GLN B C   1 
ATOM   1580 O O   . GLN B 1 58  ? -18.85800 -0.99200  -6.54800  1.000 30.78796 ? 58  GLN B O   1 
ATOM   1581 C CB  . GLN B 1 58  ? -20.10000 -0.21700  -9.54700  1.000 32.92976 ? 58  GLN B CB  1 
ATOM   1582 C CG  . GLN B 1 58  ? -19.81700 0.05000   -10.98100 1.000 29.66633 ? 58  GLN B CG  1 
ATOM   1583 C CD  . GLN B 1 58  ? -19.68600 1.52200   -11.27100 1.000 30.82162 ? 58  GLN B CD  1 
ATOM   1584 O OE1 . GLN B 1 58  ? -20.64900 2.27700   -11.13500 1.000 29.67101 ? 58  GLN B OE1 1 
ATOM   1585 N NE2 . GLN B 1 58  ? -18.49100 1.94300   -11.67800 1.000 31.71551 ? 58  GLN B NE2 1 
ATOM   1586 N N   . GLY B 1 59  ? -20.26300 0.76600   -6.66100  1.000 34.07637 ? 59  GLY B N   1 
ATOM   1587 C CA  . GLY B 1 59  ? -20.90600 0.45200   -5.39900  1.000 32.82432 ? 59  GLY B CA  1 
ATOM   1588 C C   . GLY B 1 59  ? -21.88600 -0.68500  -5.62500  1.000 40.96159 ? 59  GLY B C   1 
ATOM   1589 O O   . GLY B 1 59  ? -21.56200 -1.67100  -6.29600  1.000 45.38185 ? 59  GLY B O   1 
ATOM   1590 N N   . GLY B 1 60  ? -23.10300 -0.56200  -5.12300  1.000 38.77120 ? 60  GLY B N   1 
ATOM   1591 C CA  . GLY B 1 60  ? -24.03600 -1.66000  -5.29000  1.000 35.08135 ? 60  GLY B CA  1 
ATOM   1592 C C   . GLY B 1 60  ? -25.32300 -1.26500  -5.97200  1.000 28.20089 ? 60  GLY B C   1 
ATOM   1593 O O   . GLY B 1 60  ? -26.37600 -1.86000  -5.72400  1.000 29.33006 ? 60  GLY B O   1 
ATOM   1594 N N   . ASP B 1 61  ? -25.24700 -0.26700  -6.84700  1.000 28.02076 ? 61  ASP B N   1 
ATOM   1595 C CA  . ASP B 1 61  ? -26.44400 0.35000   -7.40500  1.000 30.41975 ? 61  ASP B CA  1 
ATOM   1596 C C   . ASP B 1 61  ? -26.80100 -0.12600  -8.81000  1.000 30.64726 ? 61  ASP B C   1 
ATOM   1597 O O   . ASP B 1 61  ? -27.96200 0.02000   -9.21000  1.000 34.21999 ? 61  ASP B O   1 
ATOM   1598 C CB  . ASP B 1 61  ? -26.27800 1.87200   -7.40600  1.000 30.49234 ? 61  ASP B CB  1 
ATOM   1599 C CG  . ASP B 1 61  ? -26.75000 2.50800   -6.10900  1.000 37.53553 ? 61  ASP B CG  1 
ATOM   1600 O OD1 . ASP B 1 61  ? -26.89500 1.79200   -5.07400  1.000 40.77592 ? 61  ASP B OD1 1 
ATOM   1601 O OD2 . ASP B 1 61  ? -26.95800 3.74000   -6.11600  1.000 41.79261 ? 61  ASP B OD2 1 
ATOM   1602 N N   . THR B 1 62  ? -25.85700 -0.67900  -9.57200  1.000 30.45143 ? 62  THR B N   1 
ATOM   1603 C CA  . THR B 1 62  ? -26.20300 -1.14900  -10.90800 1.000 28.48020 ? 62  THR B CA  1 
ATOM   1604 C C   . THR B 1 62  ? -27.19900 -2.30600  -10.83500 1.000 26.38761 ? 62  THR B C   1 
ATOM   1605 O O   . THR B 1 62  ? -27.13200 -3.15700  -9.94800  1.000 25.70187 ? 62  THR B O   1 
ATOM   1606 C CB  . THR B 1 62  ? -24.95200 -1.58800  -11.67200 1.000 30.86130 ? 62  THR B CB  1 
ATOM   1607 O OG1 . THR B 1 62  ? -23.84000 -0.73800  -11.34100 1.000 29.47325 ? 62  THR B OG1 1 
ATOM   1608 C CG2 . THR B 1 62  ? -25.20500 -1.54400  -13.18600 1.000 25.21624 ? 62  THR B CG2 1 
ATOM   1609 N N   . ILE B 1 63  ? -28.15100 -2.30700  -11.75800 1.000 24.02673 ? 63  ILE B N   1 
ATOM   1610 C CA  . ILE B 1 63  ? -29.07900 -3.41100  -11.96600 1.000 27.91467 ? 63  ILE B CA  1 
ATOM   1611 C C   . ILE B 1 63  ? -28.95300 -3.84200  -13.41800 1.000 26.30138 ? 63  ILE B C   1 
ATOM   1612 O O   . ILE B 1 63  ? -29.20300 -3.04000  -14.32700 1.000 28.04562 ? 63  ILE B O   1 
ATOM   1613 C CB  . ILE B 1 63  ? -30.53600 -3.02100  -11.65900 1.000 22.93784 ? 63  ILE B CB  1 
ATOM   1614 C CG1 . ILE B 1 63  ? -30.69900 -2.48500  -10.24500 1.000 29.54928 ? 63  ILE B CG1 1 
ATOM   1615 C CG2 . ILE B 1 63  ? -31.47200 -4.20600  -11.85100 1.000 24.67796 ? 63  ILE B CG2 1 
ATOM   1616 C CD1 . ILE B 1 63  ? -32.10600 -1.94700  -9.99800  1.000 32.14324 ? 63  ILE B CD1 1 
ATOM   1617 N N   . PHE B 1 64  ? -28.58500 -5.10100  -13.64200 1.000 26.28735 ? 64  PHE B N   1 
ATOM   1618 C CA  . PHE B 1 64  ? -28.56700 -5.67500  -14.98600 1.000 23.16954 ? 64  PHE B CA  1 
ATOM   1619 C C   . PHE B 1 64  ? -29.68600 -6.70100  -15.07800 1.000 25.36130 ? 64  PHE B C   1 
ATOM   1620 O O   . PHE B 1 64  ? -29.64800 -7.72400  -14.38600 1.000 22.73551 ? 64  PHE B O   1 
ATOM   1621 C CB  . PHE B 1 64  ? -27.22700 -6.31600  -15.30800 1.000 23.93683 ? 64  PHE B CB  1 
ATOM   1622 C CG  . PHE B 1 64  ? -27.21400 -7.06500  -16.61100 1.000 26.59140 ? 64  PHE B CG  1 
ATOM   1623 C CD1 . PHE B 1 64  ? -27.86600 -6.56200  -17.72800 1.000 22.38351 ? 64  PHE B CD1 1 
ATOM   1624 C CD2 . PHE B 1 64  ? -26.56600 -8.28700  -16.71300 1.000 25.63064 ? 64  PHE B CD2 1 
ATOM   1625 C CE1 . PHE B 1 64  ? -27.85400 -7.24700  -18.92500 1.000 22.64461 ? 64  PHE B CE1 1 
ATOM   1626 C CE2 . PHE B 1 64  ? -26.55900 -8.98200  -17.91500 1.000 24.41880 ? 64  PHE B CE2 1 
ATOM   1627 C CZ  . PHE B 1 64  ? -27.19800 -8.44800  -19.02000 1.000 20.98937 ? 64  PHE B CZ  1 
ATOM   1628 N N   . VAL B 1 65  ? -30.67600 -6.40900  -15.92100 1.000 21.35414 ? 65  VAL B N   1 
ATOM   1629 C CA  . VAL B 1 65  ? -31.76700 -7.32000  -16.23100 1.000 22.72569 ? 65  VAL B CA  1 
ATOM   1630 C C   . VAL B 1 65  ? -31.41200 -8.06600  -17.51400 1.000 22.64264 ? 65  VAL B C   1 
ATOM   1631 O O   . VAL B 1 65  ? -31.17200 -7.45000  -18.55900 1.000 20.97478 ? 65  VAL B O   1 
ATOM   1632 C CB  . VAL B 1 65  ? -33.09200 -6.55700  -16.39800 1.000 25.60095 ? 65  VAL B CB  1 
ATOM   1633 C CG1 . VAL B 1 65  ? -34.22900 -7.52000  -16.73400 1.000 23.13081 ? 65  VAL B CG1 1 
ATOM   1634 C CG2 . VAL B 1 65  ? -33.42100 -5.71800  -15.14200 1.000 23.39273 ? 65  VAL B CG2 1 
ATOM   1635 N N   . HIS B 1 66  ? -31.38900 -9.39100  -17.44800 1.000 21.96914 ? 66  HIS B N   1 
ATOM   1636 C CA  . HIS B 1 66  ? -31.14500 -10.20800 -18.62900 1.000 24.08309 ? 66  HIS B CA  1 
ATOM   1637 C C   . HIS B 1 66  ? -32.38600 -11.04400 -18.89000 1.000 22.87607 ? 66  HIS B C   1 
ATOM   1638 O O   . HIS B 1 66  ? -32.64400 -12.02300 -18.19000 1.000 23.40404 ? 66  HIS B O   1 
ATOM   1639 C CB  . HIS B 1 66  ? -29.90700 -11.08800 -18.45700 1.000 22.59850 ? 66  HIS B CB  1 
ATOM   1640 C CG  . HIS B 1 66  ? -29.51600 -11.80600 -19.70600 1.000 25.09704 ? 66  HIS B CG  1 
ATOM   1641 N ND1 . HIS B 1 66  ? -28.68500 -12.90300 -19.70600 1.000 26.78936 ? 66  HIS B ND1 1 
ATOM   1642 C CD2 . HIS B 1 66  ? -29.86200 -11.59500 -21.00000 1.000 25.19543 ? 66  HIS B CD2 1 
ATOM   1643 C CE1 . HIS B 1 66  ? -28.52900 -13.33400 -20.94600 1.000 20.78317 ? 66  HIS B CE1 1 
ATOM   1644 N NE2 . HIS B 1 66  ? -29.23000 -12.55400 -21.75200 1.000 21.38166 ? 66  HIS B NE2 1 
ATOM   1645 N N   . GLY B 1 67  ? -33.15500 -10.65500 -19.91500 1.000 23.05405 ? 67  GLY B N   1 
ATOM   1646 C CA  . GLY B 1 67  ? -34.39300 -11.33700 -20.25300 1.000 20.84091 ? 67  GLY B CA  1 
ATOM   1647 C C   . GLY B 1 67  ? -34.16700 -12.39000 -21.31200 1.000 23.30662 ? 67  GLY B C   1 
ATOM   1648 O O   . GLY B 1 67  ? -33.59900 -12.12100 -22.37600 1.000 22.81080 ? 67  GLY B O   1 
ATOM   1649 N N   . LEU B 1 68  ? -34.61600 -13.60400 -21.01600 1.000 24.51973 ? 68  LEU B N   1 
ATOM   1650 C CA  . LEU B 1 68  ? -34.53600 -14.74400 -21.91800 1.000 23.76451 ? 68  LEU B CA  1 
ATOM   1651 C C   . LEU B 1 68  ? -35.95000 -15.02000 -22.42600 1.000 27.58507 ? 68  LEU B C   1 
ATOM   1652 O O   . LEU B 1 68  ? -36.80200 -15.50600 -21.66600 1.000 23.95151 ? 68  LEU B O   1 
ATOM   1653 C CB  . LEU B 1 68  ? -33.93000 -15.95000 -21.18900 1.000 24.81433 ? 68  LEU B CB  1 
ATOM   1654 C CG  . LEU B 1 68  ? -32.65200 -15.64500 -20.37000 1.000 25.26860 ? 68  LEU B CG  1 
ATOM   1655 C CD1 . LEU B 1 68  ? -32.20600 -16.77700 -19.45100 1.000 24.96181 ? 68  LEU B CD1 1 
ATOM   1656 C CD2 . LEU B 1 68  ? -31.50100 -15.26900 -21.28500 1.000 28.74397 ? 68  LEU B CD2 1 
ATOM   1657 N N   . HIS B 1 69  ? -36.19000 -14.71300 -23.70700 1.000 24.41580 ? 69  HIS B N   1 
ATOM   1658 C CA  . HIS B 1 69  ? -37.50500 -14.69800 -24.34300 1.000 23.85500 ? 69  HIS B CA  1 
ATOM   1659 C C   . HIS B 1 69  ? -37.63300 -15.77200 -25.42000 1.000 23.49315 ? 69  HIS B C   1 
ATOM   1660 O O   . HIS B 1 69  ? -36.64100 -16.25800 -25.97700 1.000 22.22421 ? 69  HIS B O   1 
ATOM   1661 C CB  . HIS B 1 69  ? -37.77800 -13.34800 -25.03200 1.000 22.81420 ? 69  HIS B CB  1 
ATOM   1662 C CG  . HIS B 1 69  ? -37.93200 -12.19300 -24.09700 1.000 28.88450 ? 69  HIS B CG  1 
ATOM   1663 N ND1 . HIS B 1 69  ? -37.89400 -10.88400 -24.52800 1.000 30.66848 ? 69  HIS B ND1 1 
ATOM   1664 C CD2 . HIS B 1 69  ? -38.13900 -12.14200 -22.76000 1.000 27.70864 ? 69  HIS B CD2 1 
ATOM   1665 C CE1 . HIS B 1 69  ? -38.06200 -10.07400 -23.49800 1.000 26.43815 ? 69  HIS B CE1 1 
ATOM   1666 N NE2 . HIS B 1 69  ? -38.21600 -10.81200 -22.41300 1.000 28.65097 ? 69  HIS B NE2 1 
ATOM   1667 N N   . ARG B 1 70  ? -38.88100 -16.07300 -25.77500 1.000 22.01479 ? 70  ARG B N   1 
ATOM   1668 C CA  . ARG B 1 70  ? -39.15900 -16.79100 -27.01500 1.000 23.46684 ? 70  ARG B CA  1 
ATOM   1669 C C   . ARG B 1 70  ? -39.05500 -15.85600 -28.21500 1.000 24.91311 ? 70  ARG B C   1 
ATOM   1670 O O   . ARG B 1 70  ? -39.44100 -14.68700 -28.13800 1.000 21.76387 ? 70  ARG B O   1 
ATOM   1671 C CB  . ARG B 1 70  ? -40.55100 -17.41700 -27.01300 1.000 20.84692 ? 70  ARG B CB  1 
ATOM   1672 C CG  . ARG B 1 70  ? -40.74100 -18.52600 -26.00400 1.000 27.72755 ? 70  ARG B CG  1 
ATOM   1673 C CD  . ARG B 1 70  ? -42.18600 -18.95200 -25.93700 1.000 28.08862 ? 70  ARG B CD  1 
ATOM   1674 N NE  . ARG B 1 70  ? -42.88400 -18.18200 -24.91400 1.000 27.34930 ? 70  ARG B NE  1 
ATOM   1675 C CZ  . ARG B 1 70  ? -44.17600 -17.87800 -24.93600 1.000 28.70383 ? 70  ARG B CZ  1 
ATOM   1676 N NH1 . ARG B 1 70  ? -44.97700 -18.32200 -25.88800 1.000 26.91657 ? 70  ARG B NH1 1 
ATOM   1677 N NH2 . ARG B 1 70  ? -44.66900 -17.08800 -23.98800 1.000 26.34026 ? 70  ARG B NH2 1 
ATOM   1678 N N   . GLU B 1 71  ? -38.67200 -16.43400 -29.33700 1.000 24.11789 ? 71  GLU B N   1 
ATOM   1679 C CA  . GLU B 1 71  ? -38.55900 -15.79800 -30.62500 1.000 26.67630 ? 71  GLU B CA  1 
ATOM   1680 C C   . GLU B 1 71  ? -39.93300 -15.54900 -31.16400 1.000 25.51828 ? 71  GLU B C   1 
ATOM   1681 O O   . GLU B 1 71  ? -40.83300 -16.22700 -30.84700 1.000 25.06254 ? 71  GLU B O   1 
ATOM   1682 C CB  . GLU B 1 71  ? -37.81200 -16.68900 -31.61200 1.000 20.83009 ? 71  GLU B CB  1 
ATOM   1683 C CG  . GLU B 1 71  ? -36.31500 -16.68400 -31.46200 1.000 24.12825 ? 71  GLU B CG  1 
ATOM   1684 C CD  . GLU B 1 71  ? -35.59900 -17.74300 -32.26900 1.000 28.87629 ? 71  GLU B CD  1 
ATOM   1685 O OE1 . GLU B 1 71  ? -36.19600 -18.41400 -33.07800 1.000 31.26903 ? 71  GLU B OE1 1 
ATOM   1686 O OE2 . GLU B 1 71  ? -34.41400 -17.88300 -32.09900 1.000 27.98602 ? 71  GLU B OE2 1 
ATOM   1687 N N   . GLY B 1 72  ? -40.06400 -14.56400 -32.01500 1.000 24.38458 ? 72  GLY B N   1 
ATOM   1688 C CA  . GLY B 1 72  ? -41.34200 -14.28000 -32.60800 1.000 26.91295 ? 72  GLY B CA  1 
ATOM   1689 C C   . GLY B 1 72  ? -41.94500 -12.90300 -32.47700 1.000 28.54908 ? 72  GLY B C   1 
ATOM   1690 O O   . GLY B 1 72  ? -42.89600 -12.61800 -33.13200 1.000 27.55031 ? 72  GLY B O   1 
ATOM   1691 N N   . ARG B 1 73  ? -41.40000 -12.08000 -31.61600 1.000 21.68839 ? 73  ARG B N   1 
ATOM   1692 C CA  . ARG B 1 73  ? -41.92200 -10.76500 -31.42500 1.000 26.47082 ? 73  ARG B CA  1 
ATOM   1693 C C   . ARG B 1 73  ? -41.18900 -9.71700  -32.23300 1.000 26.96138 ? 73  ARG B C   1 
ATOM   1694 O O   . ARG B 1 73  ? -40.05600 -9.89700  -32.55900 1.000 24.48853 ? 73  ARG B O   1 
ATOM   1695 C CB  . ARG B 1 73  ? -41.93500 -10.45100 -29.94400 1.000 30.69316 ? 73  ARG B CB  1 
ATOM   1696 C CG  . ARG B 1 73  ? -42.54300 -11.59100 -29.14200 1.000 28.60044 ? 73  ARG B CG  1 
ATOM   1697 C CD  . ARG B 1 73  ? -43.09400 -11.14700 -27.81600 1.000 28.88227 ? 73  ARG B CD  1 
ATOM   1698 N NE  . ARG B 1 73  ? -43.69200 -12.21700 -27.05100 1.000 29.79353 ? 73  ARG B NE  1 
ATOM   1699 C CZ  . ARG B 1 73  ? -43.06200 -12.89000 -26.10900 1.000 35.40472 ? 73  ARG B CZ  1 
ATOM   1700 N NH1 . ARG B 1 73  ? -41.82000 -12.60400 -25.83300 1.000 31.79796 ? 73  ARG B NH1 1 
ATOM   1701 N NH2 . ARG B 1 73  ? -43.67000 -13.83200 -25.44000 1.000 30.70777 ? 73  ARG B NH2 1 
ATOM   1702 N N   . SER B 1 74  ? -41.86600 -8.63600  -32.55400 1.000 22.73038 ? 74  SER B N   1 
ATOM   1703 C CA  . SER B 1 74  ? -41.31700 -7.55400  -33.31300 1.000 25.13263 ? 74  SER B CA  1 
ATOM   1704 C C   . SER B 1 74  ? -40.26300 -6.77000  -32.55200 1.000 22.55182 ? 74  SER B C   1 
ATOM   1705 O O   . SER B 1 74  ? -40.21600 -6.78200  -31.36400 1.000 25.02303 ? 74  SER B O   1 
ATOM   1706 C CB  . SER B 1 74  ? -42.43300 -6.64000  -33.85000 1.000 25.99260 ? 74  SER B CB  1 
ATOM   1707 O OG  . SER B 1 74  ? -43.05600 -5.85400  -32.88100 1.000 23.15684 ? 74  SER B OG  1 
ATOM   1708 N N   . ALA B 1 75  ? -39.41100 -6.11900  -33.28300 1.000 20.19823 ? 75  ALA B N   1 
ATOM   1709 C CA  . ALA B 1 75  ? -38.40800 -5.29900  -32.70500 1.000 22.96998 ? 75  ALA B CA  1 
ATOM   1710 C C   . ALA B 1 75  ? -39.05000 -4.14700  -31.96200 1.000 24.84151 ? 75  ALA B C   1 
ATOM   1711 O O   . ALA B 1 75  ? -38.57800 -3.73300  -30.95500 1.000 24.46554 ? 75  ALA B O   1 
ATOM   1712 C CB  . ALA B 1 75  ? -37.48100 -4.80500  -33.76400 1.000 20.50377 ? 75  ALA B CB  1 
ATOM   1713 N N   . ASP B 1 76  ? -40.14300 -3.63200  -32.48500 1.000 26.73091 ? 76  ASP B N   1 
ATOM   1714 C CA  . ASP B 1 76  ? -40.87200 -2.54800  -31.83600 1.000 24.90612 ? 76  ASP B CA  1 
ATOM   1715 C C   . ASP B 1 76  ? -41.43300 -2.97900  -30.47900 1.000 23.33283 ? 76  ASP B C   1 
ATOM   1716 O O   . ASP B 1 76  ? -41.37000 -2.22000  -29.50900 1.000 25.03142 ? 76  ASP B O   1 
ATOM   1717 C CB  . ASP B 1 76  ? -41.99300 -2.06800  -32.76500 1.000 27.77952 ? 76  ASP B CB  1 
ATOM   1718 C CG  . ASP B 1 76  ? -42.90200 -1.05300  -32.10500 1.000 35.33753 ? 76  ASP B CG  1 
ATOM   1719 O OD1 . ASP B 1 76  ? -42.38500 -0.12900  -31.43100 1.000 45.76766 ? 76  ASP B OD1 1 
ATOM   1720 O OD2 . ASP B 1 76  ? -44.13500 -1.17600  -32.24600 1.000 48.32218 ? 76  ASP B OD2 1 
ATOM   1721 N N   . LEU B 1 77  ? -42.00700 -4.18400  -30.39500 1.000 23.62344 ? 77  LEU B N   1 
ATOM   1722 C CA  . LEU B 1 77  ? -42.53100 -4.67700  -29.11500 1.000 26.64832 ? 77  LEU B CA  1 
ATOM   1723 C C   . LEU B 1 77  ? -41.41200 -4.87300  -28.10000 1.000 23.37143 ? 77  LEU B C   1 
ATOM   1724 O O   . LEU B 1 77  ? -41.54800 -4.49600  -26.93000 1.000 21.20567 ? 77  LEU B O   1 
ATOM   1725 C CB  . LEU B 1 77  ? -43.30400 -5.98700  -29.33500 1.000 25.44586 ? 77  LEU B CB  1 
ATOM   1726 C CG  . LEU B 1 77  ? -44.21100 -6.62200  -28.26000 1.000 32.49236 ? 77  LEU B CG  1 
ATOM   1727 C CD1 . LEU B 1 77  ? -43.42600 -7.56500  -27.35800 1.000 34.50576 ? 77  LEU B CD1 1 
ATOM   1728 C CD2 . LEU B 1 77  ? -44.90700 -5.56700  -27.42000 1.000 30.96982 ? 77  LEU B CD2 1 
ATOM   1729 N N   . LYS B 1 78  ? -40.29100 -5.45400  -28.52800 1.000 22.96084 ? 78  LYS B N   1 
ATOM   1730 C CA  . LYS B 1 78  ? -39.17300 -5.62800  -27.61300 1.000 23.70806 ? 78  LYS B CA  1 
ATOM   1731 C C   . LYS B 1 78  ? -38.63000 -4.28000  -27.14200 1.000 20.97859 ? 78  LYS B C   1 
ATOM   1732 O O   . LYS B 1 78  ? -38.27000 -4.12800  -25.97100 1.000 21.12840 ? 78  LYS B O   1 
ATOM   1733 C CB  . LYS B 1 78  ? -38.09400 -6.47900  -28.28100 1.000 21.68727 ? 78  LYS B CB  1 
ATOM   1734 C CG  . LYS B 1 78  ? -38.54200 -7.94300  -28.43900 1.000 27.59034 ? 78  LYS B CG  1 
ATOM   1735 C CD  . LYS B 1 78  ? -37.48400 -8.83100  -29.10500 1.000 24.10044 ? 78  LYS B CD  1 
ATOM   1736 C CE  . LYS B 1 78  ? -37.39200 -8.57600  -30.62000 1.000 23.47893 ? 78  LYS B CE  1 
ATOM   1737 N NZ  . LYS B 1 78  ? -36.32700 -9.43900  -31.19900 1.000 23.54957 ? 78  LYS B NZ  1 
ATOM   1738 N N   . GLY B 1 79  ? -38.62100 -3.27700  -28.02600 1.000 23.09909 ? 79  GLY B N   1 
ATOM   1739 C CA  . GLY B 1 79  ? -38.21200 -1.93700  -27.61900 1.000 21.30122 ? 79  GLY B CA  1 
ATOM   1740 C C   . GLY B 1 79  ? -39.11100 -1.34100  -26.55000 1.000 23.33155 ? 79  GLY B C   1 
ATOM   1741 O O   . GLY B 1 79  ? -38.63800 -0.79700  -25.55100 1.000 22.48347 ? 79  GLY B O   1 
ATOM   1742 N N   . GLN B 1 80  ? -40.42600 -1.42600  -26.74700 1.000 23.72092 ? 80  GLN B N   1 
ATOM   1743 C CA  . GLN B 1 80  ? -41.35200 -0.93200  -25.73200 1.000 25.01694 ? 80  GLN B CA  1 
ATOM   1744 C C   . GLN B 1 80  ? -41.23100 -1.72300  -24.43500 1.000 21.60964 ? 80  GLN B C   1 
ATOM   1745 O O   . GLN B 1 80  ? -41.34100 -1.15900  -23.34500 1.000 22.45324 ? 80  GLN B O   1 
ATOM   1746 C CB  . GLN B 1 80  ? -42.79200 -1.01000  -26.24900 1.000 28.28630 ? 80  GLN B CB  1 
ATOM   1747 C CG  . GLN B 1 80  ? -43.04300 -0.35200  -27.58200 1.000 26.93351 ? 80  GLN B CG  1 
ATOM   1748 C CD  . GLN B 1 80  ? -44.52200 -0.36100  -27.91200 1.000 42.59435 ? 80  GLN B CD  1 
ATOM   1749 O OE1 . GLN B 1 80  ? -45.35400 0.01900   -27.08200 1.000 43.83781 ? 80  GLN B OE1 1 
ATOM   1750 N NE2 . GLN B 1 80  ? -44.86200 -0.80500  -29.11900 1.000 39.35758 ? 80  GLN B NE2 1 
ATOM   1751 N N   . LEU B 1 81  ? -41.02000 -3.03500  -24.52600 1.000 22.95142 ? 81  LEU B N   1 
ATOM   1752 C CA  . LEU B 1 81  ? -40.92700 -3.83900  -23.30800 1.000 24.20316 ? 81  LEU B CA  1 
ATOM   1753 C C   . LEU B 1 81  ? -39.62000 -3.56000  -22.56900 1.000 25.22668 ? 81  LEU B C   1 
ATOM   1754 O O   . LEU B 1 81  ? -39.61200 -3.45500  -21.33500 1.000 22.30376 ? 81  LEU B O   1 
ATOM   1755 C CB  . LEU B 1 81  ? -41.06900 -5.32900  -23.64500 1.000 20.82298 ? 81  LEU B CB  1 
ATOM   1756 C CG  . LEU B 1 81  ? -40.84500 -6.35900  -22.52700 1.000 23.34449 ? 81  LEU B CG  1 
ATOM   1757 C CD1 . LEU B 1 81  ? -41.74000 -6.11700  -21.31800 1.000 19.17157 ? 81  LEU B CD1 1 
ATOM   1758 C CD2 . LEU B 1 81  ? -41.03400 -7.78900  -23.07900 1.000 21.17825 ? 81  LEU B CD2 1 
ATOM   1759 N N   . ALA B 1 82  ? -38.50800 -3.42400  -23.30100 1.000 18.96170 ? 82  ALA B N   1 
ATOM   1760 C CA  . ALA B 1 82  ? -37.25900 -3.01000  -22.66000 1.000 24.62438 ? 82  ALA B CA  1 
ATOM   1761 C C   . ALA B 1 82  ? -37.44600 -1.68500  -21.92700 1.000 27.10628 ? 82  ALA B C   1 
ATOM   1762 O O   . ALA B 1 82  ? -37.05800 -1.54500  -20.76500 1.000 23.94739 ? 82  ALA B O   1 
ATOM   1763 C CB  . ALA B 1 82  ? -36.13700 -2.88600  -23.69200 1.000 19.11665 ? 82  ALA B CB  1 
ATOM   1764 N N   . GLN B 1 83  ? -38.06600 -0.70700  -22.59600 1.000 25.85194 ? 83  GLN B N   1 
ATOM   1765 C CA  . GLN B 1 83  ? -38.20600 0.63200   -22.03500 1.000 23.78141 ? 83  GLN B CA  1 
ATOM   1766 C C   . GLN B 1 83  ? -39.14000 0.63800   -20.83100 1.000 24.05816 ? 83  GLN B C   1 
ATOM   1767 O O   . GLN B 1 83  ? -38.88900 1.35400   -19.85400 1.000 23.66824 ? 83  GLN B O   1 
ATOM   1768 C CB  . GLN B 1 83  ? -38.70800 1.59800   -23.11300 1.000 22.01161 ? 83  GLN B CB  1 
ATOM   1769 C CG  . GLN B 1 83  ? -38.91200 3.01900   -22.63100 1.000 28.30098 ? 83  GLN B CG  1 
ATOM   1770 C CD  . GLN B 1 83  ? -37.60500 3.65500   -22.21300 1.000 34.23343 ? 83  GLN B CD  1 
ATOM   1771 O OE1 . GLN B 1 83  ? -36.72700 3.87400   -23.04600 1.000 36.39095 ? 83  GLN B OE1 1 
ATOM   1772 N NE2 . GLN B 1 83  ? -37.45700 3.93700   -20.91600 1.000 30.50675 ? 83  GLN B NE2 1 
ATOM   1773 N N   . ARG B 1 84  ? -40.23000 -0.14100  -20.88500 1.000 22.02192 ? 84  ARG B N   1 
ATOM   1774 C CA  . ARG B 1 84  ? -41.14300 -0.22400  -19.74400 1.000 25.45578 ? 84  ARG B CA  1 
ATOM   1775 C C   . ARG B 1 84  ? -40.46900 -0.86000  -18.53200 1.000 27.88350 ? 84  ARG B C   1 
ATOM   1776 O O   . ARG B 1 84  ? -40.68600 -0.42400  -17.39100 1.000 26.97133 ? 84  ARG B O   1 
ATOM   1777 C CB  . ARG B 1 84  ? -42.40700 -1.00700  -20.11100 1.000 25.91759 ? 84  ARG B CB  1 
ATOM   1778 C CG  . ARG B 1 84  ? -43.38500 -1.08900  -18.90100 1.000 32.17227 ? 84  ARG B CG  1 
ATOM   1779 C CD  . ARG B 1 84  ? -44.87400 -1.10400  -19.27300 1.000 35.54156 ? 84  ARG B CD  1 
ATOM   1780 N NE  . ARG B 1 84  ? -45.72300 -1.60000  -18.18400 1.000 43.92788 ? 84  ARG B NE  1 
ATOM   1781 C CZ  . ARG B 1 84  ? -46.96100 -2.05800  -18.34300 1.000 46.90905 ? 84  ARG B CZ  1 
ATOM   1782 N NH1 . ARG B 1 84  ? -47.51900 -2.13800  -19.54500 1.000 43.82200 ? 84  ARG B NH1 1 
ATOM   1783 N NH2 . ARG B 1 84  ? -47.65900 -2.43800  -17.27200 1.000 39.19761 ? 84  ARG B NH2 1 
ATOM   1784 N N   . ILE B 1 85  ? -39.66700 -1.90700  -18.75500 1.000 27.78726 ? 85  ILE B N   1 
ATOM   1785 C CA  . ILE B 1 85  ? -38.89800 -2.49900  -17.66700 1.000 22.96264 ? 85  ILE B CA  1 
ATOM   1786 C C   . ILE B 1 85  ? -37.96500 -1.46300  -17.05700 1.000 23.30024 ? 85  ILE B C   1 
ATOM   1787 O O   . ILE B 1 85  ? -37.83900 -1.37300  -15.83400 1.000 23.63403 ? 85  ILE B O   1 
ATOM   1788 C CB  . ILE B 1 85  ? -38.12700 -3.72400  -18.17700 1.000 24.77509 ? 85  ILE B CB  1 
ATOM   1789 C CG1 . ILE B 1 85  ? -39.11400 -4.83800  -18.51500 1.000 26.40839 ? 85  ILE B CG1 1 
ATOM   1790 C CG2 . ILE B 1 85  ? -37.06400 -4.18300  -17.15100 1.000 20.92038 ? 85  ILE B CG2 1 
ATOM   1791 C CD1 . ILE B 1 85  ? -38.45200 -6.15900  -18.83900 1.000 26.60593 ? 85  ILE B CD1 1 
ATOM   1792 N N   . VAL B 1 86  ? -37.30400 -0.65800  -17.89500 1.000 22.94504 ? 86  VAL B N   1 
ATOM   1793 C CA  . VAL B 1 86  ? -36.44700 0.41000   -17.37500 1.000 22.93729 ? 86  VAL B CA  1 
ATOM   1794 C C   . VAL B 1 86  ? -37.24800 1.35200   -16.48500 1.000 27.54480 ? 86  VAL B C   1 
ATOM   1795 O O   . VAL B 1 86  ? -36.87200 1.62600   -15.34100 1.000 30.91260 ? 86  VAL B O   1 
ATOM   1796 C CB  . VAL B 1 86  ? -35.77900 1.18200   -18.52400 1.000 25.10910 ? 86  VAL B CB  1 
ATOM   1797 C CG1 . VAL B 1 86  ? -35.03100 2.37900   -17.96900 1.000 25.17715 ? 86  VAL B CG1 1 
ATOM   1798 C CG2 . VAL B 1 86  ? -34.85300 0.25700   -19.37500 1.000 21.67664 ? 86  VAL B CG2 1 
ATOM   1799 N N   . ASP B 1 87  ? -38.36300 1.86200   -17.00200 1.000 22.97897 ? 87  ASP B N   1 
ATOM   1800 C CA  . ASP B 1 87  ? -39.16200 2.84700   -16.28000 1.000 22.98607 ? 87  ASP B CA  1 
ATOM   1801 C C   . ASP B 1 87  ? -39.75200 2.24100   -15.01500 1.000 23.51657 ? 87  ASP B C   1 
ATOM   1802 O O   . ASP B 1 87  ? -39.68100 2.83400   -13.93600 1.000 25.59640 ? 87  ASP B O   1 
ATOM   1803 C CB  . ASP B 1 87  ? -40.29300 3.37600   -17.18300 1.000 27.91317 ? 87  ASP B CB  1 
ATOM   1804 C CG  . ASP B 1 87  ? -39.79000 4.32200   -18.29700 1.000 32.28486 ? 87  ASP B CG  1 
ATOM   1805 O OD1 . ASP B 1 87  ? -38.62000 4.76900   -18.25400 1.000 35.55013 ? 87  ASP B OD1 1 
ATOM   1806 O OD2 . ASP B 1 87  ? -40.55700 4.57200   -19.25500 1.000 34.31549 ? 87  ASP B OD2 1 
ATOM   1807 N N   . ASP B 1 88  ? -40.34000 1.05300   -15.12900 1.000 25.25057 ? 88  ASP B N   1 
ATOM   1808 C CA  . ASP B 1 88  ? -41.05900 0.48600   -13.99800 1.000 24.23471 ? 88  ASP B CA  1 
ATOM   1809 C C   . ASP B 1 88  ? -40.11500 -0.06300  -12.94200 1.000 26.58556 ? 88  ASP B C   1 
ATOM   1810 O O   . ASP B 1 88  ? -40.46800 -0.07200  -11.76100 1.000 20.44600 ? 88  ASP B O   1 
ATOM   1811 C CB  . ASP B 1 88  ? -42.02300 -0.61600  -14.45800 1.000 27.60573 ? 88  ASP B CB  1 
ATOM   1812 C CG  . ASP B 1 88  ? -43.20500 -0.07100  -15.23700 1.000 30.97139 ? 88  ASP B CG  1 
ATOM   1813 O OD1 . ASP B 1 88  ? -43.33300 1.17800   -15.33500 1.000 27.92007 ? 88  ASP B OD1 1 
ATOM   1814 O OD2 . ASP B 1 88  ? -43.99200 -0.89200  -15.74900 1.000 32.24952 ? 88  ASP B OD2 1 
ATOM   1815 N N   . VAL B 1 89  ? -38.93000 -0.54500  -13.33000 1.000 26.31967 ? 89  VAL B N   1 
ATOM   1816 C CA  . VAL B 1 89  ? -37.99200 -1.00300  -12.31400 1.000 25.58002 ? 89  VAL B CA  1 
ATOM   1817 C C   . VAL B 1 89  ? -37.38600 0.19200   -11.59300 1.000 25.84016 ? 89  VAL B C   1 
ATOM   1818 O O   . VAL B 1 89  ? -37.18900 0.17100   -10.37400 1.000 29.80434 ? 89  VAL B O   1 
ATOM   1819 C CB  . VAL B 1 89  ? -36.91300 -1.90300  -12.93400 1.000 23.91594 ? 89  VAL B CB  1 
ATOM   1820 C CG1 . VAL B 1 89  ? -35.75900 -2.08200  -11.96300 1.000 20.26548 ? 89  VAL B CG1 1 
ATOM   1821 C CG2 . VAL B 1 89  ? -37.49800 -3.27200  -13.29100 1.000 24.75486 ? 89  VAL B CG2 1 
ATOM   1822 N N   . SER B 1 90  ? -37.09400 1.24800   -12.34000 1.000 24.41204 ? 90  SER B N   1 
ATOM   1823 C CA  . SER B 1 90  ? -36.61600 2.49000   -11.76000 1.000 24.33024 ? 90  SER B CA  1 
ATOM   1824 C C   . SER B 1 90  ? -37.57000 2.99900   -10.68900 1.000 25.88454 ? 90  SER B C   1 
ATOM   1825 O O   . SER B 1 90  ? -37.13300 3.47700   -9.63600  1.000 27.78593 ? 90  SER B O   1 
ATOM   1826 C CB  . SER B 1 90  ? -36.44500 3.52500   -12.87200 1.000 25.38309 ? 90  SER B CB  1 
ATOM   1827 O OG  . SER B 1 90  ? -35.77400 4.68700   -12.41500 1.000 32.23424 ? 90  SER B OG  1 
ATOM   1828 N N   . VAL B 1 91  ? -38.87800 2.88900   -10.94000 1.000 25.77494 ? 91  VAL B N   1 
ATOM   1829 C CA  . VAL B 1 91  ? -39.88000 3.34100   -9.98100  1.000 25.42091 ? 91  VAL B CA  1 
ATOM   1830 C C   . VAL B 1 91  ? -39.99300 2.36000   -8.82600  1.000 29.11766 ? 91  VAL B C   1 
ATOM   1831 O O   . VAL B 1 91  ? -40.01700 2.75300   -7.65200  1.000 27.30302 ? 91  VAL B O   1 
ATOM   1832 C CB  . VAL B 1 91  ? -41.23400 3.53300   -10.68300 1.000 28.43144 ? 91  VAL B CB  1 
ATOM   1833 C CG1 . VAL B 1 91  ? -42.38300 3.55900   -9.64700  1.000 28.38217 ? 91  VAL B CG1 1 
ATOM   1834 C CG2 . VAL B 1 91  ? -41.20700 4.79100   -11.50700 1.000 21.50182 ? 91  VAL B CG2 1 
ATOM   1835 N N   . ALA B 1 92  ? -40.07600 1.06800   -9.14100  1.000 25.42546 ? 92  ALA B N   1 
ATOM   1836 C CA  . ALA B 1 92  ? -40.23100 0.05800   -8.10200  1.000 28.58913 ? 92  ALA B CA  1 
ATOM   1837 C C   . ALA B 1 92  ? -39.09600 0.12700   -7.08100  1.000 31.15860 ? 92  ALA B C   1 
ATOM   1838 O O   . ALA B 1 92  ? -39.34400 0.16500   -5.87300  1.000 31.26358 ? 92  ALA B O   1 
ATOM   1839 C CB  . ALA B 1 92  ? -40.33000 -1.33400  -8.73300  1.000 22.46315 ? 92  ALA B CB  1 
ATOM   1840 N N   . ALA B 1 93  ? -37.84400 0.16500   -7.54400  1.000 29.43719 ? 93  ALA B N   1 
ATOM   1841 C CA  . ALA B 1 93  ? -36.69700 0.14100   -6.64400  1.000 27.13296 ? 93  ALA B CA  1 
ATOM   1842 C C   . ALA B 1 93  ? -36.15600 1.52500   -6.29100  1.000 29.97693 ? 93  ALA B C   1 
ATOM   1843 O O   . ALA B 1 93  ? -35.14900 1.61400   -5.58100  1.000 31.23500 ? 93  ALA B O   1 
ATOM   1844 C CB  . ALA B 1 93  ? -35.57600 -0.70000  -7.25400  1.000 35.77828 ? 93  ALA B CB  1 
ATOM   1845 N N   . GLU B 1 94  ? -36.77300 2.59700   -6.79000  1.000 29.75202 ? 94  GLU B N   1 
ATOM   1846 C CA  . GLU B 1 94  ? -36.38800 3.96900   -6.43600  1.000 31.36602 ? 94  GLU B CA  1 
ATOM   1847 C C   . GLU B 1 94  ? -34.91700 4.21500   -6.76300  1.000 33.28776 ? 94  GLU B C   1 
ATOM   1848 O O   . GLU B 1 94  ? -34.15100 4.73700   -5.95600  1.000 34.38943 ? 94  GLU B O   1 
ATOM   1849 C CB  . GLU B 1 94  ? -36.68800 4.23500   -4.96000  1.000 28.45669 ? 94  GLU B CB  1 
ATOM   1850 C CG  . GLU B 1 94  ? -38.18900 4.12900   -4.71300  1.000 35.18418 ? 94  GLU B CG  1 
ATOM   1851 C CD  . GLU B 1 94  ? -38.72900 5.11400   -3.69400  1.000 39.07002 ? 94  GLU B CD  1 
ATOM   1852 O OE1 . GLU B 1 94  ? -38.15000 5.26700   -2.61800  1.000 40.26303 ? 94  GLU B OE1 1 
ATOM   1853 O OE2 . GLU B 1 94  ? -39.81900 5.68600   -3.96400  1.000 48.72458 ? 94  GLU B OE2 1 
ATOM   1854 N N   . ILE B 1 95  ? -34.52300 3.81400   -7.96300  1.000 32.88404 ? 95  ILE B N   1 
ATOM   1855 C CA  . ILE B 1 95  ? -33.15900 3.99700   -8.44000  1.000 30.80171 ? 95  ILE B CA  1 
ATOM   1856 C C   . ILE B 1 95  ? -33.20000 4.77700   -9.74300  1.000 27.95268 ? 95  ILE B C   1 
ATOM   1857 O O   . ILE B 1 95  ? -34.14700 4.65400   -10.52500 1.000 31.20122 ? 95  ILE B O   1 
ATOM   1858 C CB  . ILE B 1 95  ? -32.39800 2.65400   -8.59700  1.000 33.34893 ? 95  ILE B CB  1 
ATOM   1859 C CG1 . ILE B 1 95  ? -32.35700 1.88000   -7.27400  1.000 38.13697 ? 95  ILE B CG1 1 
ATOM   1860 C CG2 . ILE B 1 95  ? -30.96800 2.87000   -9.07900  1.000 34.06735 ? 95  ILE B CG2 1 
ATOM   1861 C CD1 . ILE B 1 95  ? -32.25200 0.36000   -7.43300  1.000 36.26024 ? 95  ILE B CD1 1 
ATOM   1862 N N   . ASP B 1 96  ? -32.20600 5.62500   -9.92700  1.000 25.19459 ? 96  ASP B N   1 
ATOM   1863 C CA  . ASP B 1 96  ? -32.06900 6.39500   -11.15100 1.000 26.05202 ? 96  ASP B CA  1 
ATOM   1864 C C   . ASP B 1 96  ? -31.90800 5.44700   -12.34100 1.000 25.78056 ? 96  ASP B C   1 
ATOM   1865 O O   . ASP B 1 96  ? -31.17000 4.45800   -12.27700 1.000 25.75144 ? 96  ASP B O   1 
ATOM   1866 C CB  . ASP B 1 96  ? -30.86100 7.32900   -11.03200 1.000 27.44906 ? 96  ASP B CB  1 
ATOM   1867 C CG  . ASP B 1 96  ? -30.76000 8.30300   -12.17000 1.000 30.54936 ? 96  ASP B CG  1 
ATOM   1868 O OD1 . ASP B 1 96  ? -30.72400 7.86200   -13.33100 1.000 34.06488 ? 96  ASP B OD1 1 
ATOM   1869 O OD2 . ASP B 1 96  ? -30.68800 9.51700   -11.91200 1.000 47.05108 ? 96  ASP B OD2 1 
ATOM   1870 N N   . ARG B 1 97  ? -32.62100 5.75000   -13.42900 1.000 27.61036 ? 97  ARG B N   1 
ATOM   1871 C CA  . ARG B 1 97  ? -32.61400 4.90400   -14.61900 1.000 25.25714 ? 97  ARG B CA  1 
ATOM   1872 C C   . ARG B 1 97  ? -31.22000 4.66600   -15.17300 1.000 26.25303 ? 97  ARG B C   1 
ATOM   1873 O O   . ARG B 1 97  ? -31.02800 3.69400   -15.91200 1.000 25.62425 ? 97  ARG B O   1 
ATOM   1874 C CB  . ARG B 1 97  ? -33.47900 5.50700   -15.73600 1.000 26.79552 ? 97  ARG B CB  1 
ATOM   1875 C CG  . ARG B 1 97  ? -34.96800 5.65100   -15.44700 1.000 35.49595 ? 97  ARG B CG  1 
ATOM   1876 C CD  . ARG B 1 97  ? -35.80500 5.76500   -16.76100 1.000 39.91094 ? 97  ARG B CD  1 
ATOM   1877 N NE  . ARG B 1 97  ? -35.28500 6.80100   -17.65200 1.000 52.35753 ? 97  ARG B NE  1 
ATOM   1878 C CZ  . ARG B 1 97  ? -34.72500 6.58900   -18.84300 1.000 50.90936 ? 97  ARG B CZ  1 
ATOM   1879 N NH1 . ARG B 1 97  ? -34.69400 5.38600   -19.40300 1.000 41.28595 ? 97  ARG B NH1 1 
ATOM   1880 N NH2 . ARG B 1 97  ? -34.17600 7.61500   -19.49000 1.000 51.49202 ? 97  ARG B NH2 1 
ATOM   1881 N N   . LYS B 1 98  ? -30.24400 5.52800   -14.85100 1.000 24.06616 ? 98  LYS B N   1 
ATOM   1882 C CA  . LYS B 1 98  ? -28.88500 5.38800   -15.38100 1.000 25.02742 ? 98  LYS B CA  1 
ATOM   1883 C C   . LYS B 1 98  ? -28.13700 4.19900   -14.79000 1.000 27.88285 ? 98  LYS B C   1 
ATOM   1884 O O   . LYS B 1 98  ? -27.02800 3.88200   -15.26200 1.000 23.21804 ? 98  LYS B O   1 
ATOM   1885 C CB  . LYS B 1 98  ? -28.08500 6.67200   -15.15000 1.000 31.16887 ? 98  LYS B CB  1 
ATOM   1886 C CG  . LYS B 1 98  ? -28.67600 7.92000   -15.81300 1.000 31.97133 ? 98  LYS B CG  1 
ATOM   1887 C CD  . LYS B 1 98  ? -27.70500 9.11600   -15.73500 1.000 33.71594 ? 98  LYS B CD  1 
ATOM   1888 C CE  . LYS B 1 98  ? -28.24000 10.22300  -14.81800 1.000 46.82482 ? 98  LYS B CE  1 
ATOM   1889 N NZ  . LYS B 1 98  ? -29.46800 10.91700  -15.37000 1.000 51.07063 ? 98  LYS B NZ  1 
ATOM   1890 N N   . HIS B 1 99  ? -28.71100 3.54700   -13.77200 1.000 26.56737 ? 99  HIS B N   1 
ATOM   1891 C CA  . HIS B 1 99  ? -28.16200 2.34800   -13.15400 1.000 27.86851 ? 99  HIS B CA  1 
ATOM   1892 C C   . HIS B 1 99  ? -28.69700 1.05200   -13.77000 1.000 30.49872 ? 99  HIS B C   1 
ATOM   1893 O O   . HIS B 1 99  ? -28.28900 -0.03600  -13.34200 1.000 30.87934 ? 99  HIS B O   1 
ATOM   1894 C CB  . HIS B 1 99  ? -28.47800 2.35600   -11.64700 1.000 30.49423 ? 99  HIS B CB  1 
ATOM   1895 C CG  . HIS B 1 99  ? -27.73800 3.40700   -10.87800 1.000 31.32779 ? 99  HIS B CG  1 
ATOM   1896 N ND1 . HIS B 1 99  ? -26.36300 3.50300   -10.89000 1.000 32.48643 ? 99  HIS B ND1 1 
ATOM   1897 C CD2 . HIS B 1 99  ? -28.17800 4.40300   -10.07200 1.000 25.77223 ? 99  HIS B CD2 1 
ATOM   1898 C CE1 . HIS B 1 99  ? -25.98900 4.51700   -10.12800 1.000 32.81558 ? 99  HIS B CE1 1 
ATOM   1899 N NE2 . HIS B 1 99  ? -27.07100 5.07800   -9.62000  1.000 31.36382 ? 99  HIS B NE2 1 
ATOM   1900 N N   . ILE B 1 100 ? -29.60700 1.13500   -14.73900 1.000 25.59213 ? 100 ILE B N   1 
ATOM   1901 C CA  . ILE B 1 100 ? -30.40800 -0.00500  -15.17600 1.000 24.32769 ? 100 ILE B CA  1 
ATOM   1902 C C   . ILE B 1 100 ? -29.95700 -0.42300  -16.57000 1.000 22.88395 ? 100 ILE B C   1 
ATOM   1903 O O   . ILE B 1 100 ? -29.94600 0.38500   -17.50600 1.000 22.13446 ? 100 ILE B O   1 
ATOM   1904 C CB  . ILE B 1 100 ? -31.90700 0.32200   -15.13400 1.000 23.85798 ? 100 ILE B CB  1 
ATOM   1905 C CG1 . ILE B 1 100 ? -32.28900 0.77300   -13.70800 1.000 25.74370 ? 100 ILE B CG1 1 
ATOM   1906 C CG2 . ILE B 1 100 ? -32.71800 -0.88500  -15.52800 1.000 19.55428 ? 100 ILE B CG2 1 
ATOM   1907 C CD1 . ILE B 1 100 ? -33.74900 1.08600   -13.49400 1.000 25.33542 ? 100 ILE B CD1 1 
ATOM   1908 N N   . TRP B 1 101 ? -29.54100 -1.67300  -16.68600 1.000 20.04351 ? 101 TRP B N   1 
ATOM   1909 C CA  . TRP B 1 101 ? -29.14000 -2.28800  -17.94200 1.000 24.37428 ? 101 TRP B CA  1 
ATOM   1910 C C   . TRP B 1 101 ? -30.12700 -3.40400  -18.23900 1.000 22.94294 ? 101 TRP B C   1 
ATOM   1911 O O   . TRP B 1 101 ? -30.53400 -4.12600  -17.31900 1.000 24.98273 ? 101 TRP B O   1 
ATOM   1912 C CB  . TRP B 1 101 ? -27.71800 -2.86800  -17.84700 1.000 22.43160 ? 101 TRP B CB  1 
ATOM   1913 C CG  . TRP B 1 101 ? -26.64300 -1.85200  -17.60200 1.000 24.42536 ? 101 TRP B CG  1 
ATOM   1914 C CD1 . TRP B 1 101 ? -26.69500 -0.75700  -16.75800 1.000 26.54793 ? 101 TRP B CD1 1 
ATOM   1915 C CD2 . TRP B 1 101 ? -25.35100 -1.81800  -18.22000 1.000 23.23402 ? 101 TRP B CD2 1 
ATOM   1916 N NE1 . TRP B 1 101 ? -25.51000 -0.06100  -16.82200 1.000 24.42673 ? 101 TRP B NE1 1 
ATOM   1917 C CE2 . TRP B 1 101 ? -24.67400 -0.68700  -17.71600 1.000 25.80785 ? 101 TRP B CE2 1 
ATOM   1918 C CE3 . TRP B 1 101 ? -24.70100 -2.63400  -19.14700 1.000 18.94074 ? 101 TRP B CE3 1 
ATOM   1919 C CZ2 . TRP B 1 101 ? -23.37900 -0.35700  -18.11500 1.000 21.58581 ? 101 TRP B CZ2 1 
ATOM   1920 C CZ3 . TRP B 1 101 ? -23.41900 -2.29800  -19.55000 1.000 21.65103 ? 101 TRP B CZ3 1 
ATOM   1921 C CH2 . TRP B 1 101 ? -22.76900 -1.17600  -19.03000 1.000 20.10437 ? 101 TRP B CH2 1 
ATOM   1922 N N   . VAL B 1 102 ? -30.53300 -3.54000  -19.50200 1.000 20.02019 ? 102 VAL B N   1 
ATOM   1923 C CA  . VAL B 1 102 ? -31.53700 -4.53800  -19.88200 1.000 20.36565 ? 102 VAL B CA  1 
ATOM   1924 C C   . VAL B 1 102 ? -31.16200 -5.14500  -21.23000 1.000 20.71872 ? 102 VAL B C   1 
ATOM   1925 O O   . VAL B 1 102 ? -31.16800 -4.44400  -22.24300 1.000 20.94583 ? 102 VAL B O   1 
ATOM   1926 C CB  . VAL B 1 102 ? -32.95700 -3.93400  -19.96100 1.000 17.60992 ? 102 VAL B CB  1 
ATOM   1927 C CG1 . VAL B 1 102 ? -33.93100 -4.98200  -20.42200 1.000 16.53533 ? 102 VAL B CG1 1 
ATOM   1928 C CG2 . VAL B 1 102 ? -33.40000 -3.37300  -18.60100 1.000 19.31471 ? 102 VAL B CG2 1 
ATOM   1929 N N   . PHE B 1 103 ? -30.87100 -6.44400  -21.25900 1.000 20.12621 ? 103 PHE B N   1 
ATOM   1930 C CA  . PHE B 1 103 ? -30.63400 -7.17700  -22.50400 1.000 18.12561 ? 103 PHE B CA  1 
ATOM   1931 C C   . PHE B 1 103 ? -31.69100 -8.26200  -22.66800 1.000 21.41971 ? 103 PHE B C   1 
ATOM   1932 O O   . PHE B 1 103 ? -31.98900 -8.99500  -21.71000 1.000 21.31181 ? 103 PHE B O   1 
ATOM   1933 C CB  . PHE B 1 103 ? -29.23900 -7.87500  -22.55000 1.000 20.55140 ? 103 PHE B CB  1 
ATOM   1934 C CG  . PHE B 1 103 ? -28.04800 -6.94300  -22.51000 1.000 21.04521 ? 103 PHE B CG  1 
ATOM   1935 C CD1 . PHE B 1 103 ? -28.20000 -5.56900  -22.54700 1.000 21.58853 ? 103 PHE B CD1 1 
ATOM   1936 C CD2 . PHE B 1 103 ? -26.76500 -7.46400  -22.48900 1.000 20.85495 ? 103 PHE B CD2 1 
ATOM   1937 C CE1 . PHE B 1 103 ? -27.09300 -4.72600  -22.51300 1.000 23.75514 ? 103 PHE B CE1 1 
ATOM   1938 C CE2 . PHE B 1 103 ? -25.63800 -6.62600  -22.48100 1.000 19.72789 ? 103 PHE B CE2 1 
ATOM   1939 C CZ  . PHE B 1 103 ? -25.80600 -5.25600  -22.48600 1.000 22.94587 ? 103 PHE B CZ  1 
ATOM   1940 N N   . PHE B 1 104 ? -32.25200 -8.37000  -23.87900 1.000 19.20307 ? 104 PHE B N   1 
ATOM   1941 C CA  . PHE B 1 104 ? -33.15600 -9.46600  -24.24100 1.000 22.49362 ? 104 PHE B CA  1 
ATOM   1942 C C   . PHE B 1 104 ? -32.44400 -10.46200 -25.14400 1.000 19.54212 ? 104 PHE B C   1 
ATOM   1943 O O   . PHE B 1 104 ? -31.93900 -10.09400 -26.21000 1.000 21.38472 ? 104 PHE B O   1 
ATOM   1944 C CB  . PHE B 1 104 ? -34.40200 -8.97500  -24.97200 1.000 20.55480 ? 104 PHE B CB  1 
ATOM   1945 C CG  . PHE B 1 104 ? -35.31900 -8.16800  -24.13100 1.000 21.49963 ? 104 PHE B CG  1 
ATOM   1946 C CD1 . PHE B 1 104 ? -35.19800 -8.15800  -22.74100 1.000 20.25953 ? 104 PHE B CD1 1 
ATOM   1947 C CD2 . PHE B 1 104 ? -36.31300 -7.41100  -24.72800 1.000 22.92637 ? 104 PHE B CD2 1 
ATOM   1948 C CE1 . PHE B 1 104 ? -36.05300 -7.40100  -21.96500 1.000 23.83334 ? 104 PHE B CE1 1 
ATOM   1949 C CE2 . PHE B 1 104 ? -37.17900 -6.64400  -23.95200 1.000 24.77166 ? 104 PHE B CE2 1 
ATOM   1950 C CZ  . PHE B 1 104 ? -37.05100 -6.63900  -22.56800 1.000 23.21341 ? 104 PHE B CZ  1 
ATOM   1951 N N   . GLY B 1 105 ? -32.44500 -11.72100 -24.74700 1.000 20.63365 ? 105 GLY B N   1 
ATOM   1952 C CA  . GLY B 1 105 ? -32.02300 -12.81300 -25.61100 1.000 25.11536 ? 105 GLY B CA  1 
ATOM   1953 C C   . GLY B 1 105 ? -33.23000 -13.67100 -25.94700 1.000 26.12329 ? 105 GLY B C   1 
ATOM   1954 O O   . GLY B 1 105 ? -34.12100 -13.85700 -25.10500 1.000 26.22338 ? 105 GLY B O   1 
ATOM   1955 N N   . GLU B 1 106 ? -33.25500 -14.18600 -27.17400 1.000 18.90018 ? 106 GLU B N   1 
ATOM   1956 C CA  . GLU B 1 106 ? -34.36100 -14.99000 -27.68000 1.000 23.45479 ? 106 GLU B CA  1 
ATOM   1957 C C   . GLU B 1 106 ? -33.91100 -16.38500 -28.10400 1.000 27.47535 ? 106 GLU B C   1 
ATOM   1958 O O   . GLU B 1 106 ? -32.80600 -16.58000 -28.61800 1.000 22.60297 ? 106 GLU B O   1 
ATOM   1959 C CB  . GLU B 1 106 ? -35.03400 -14.31600 -28.88600 1.000 22.05069 ? 106 GLU B CB  1 
ATOM   1960 C CG  . GLU B 1 106 ? -35.54100 -12.93300 -28.58700 1.000 23.20210 ? 106 GLU B CG  1 
ATOM   1961 C CD  . GLU B 1 106 ? -35.68500 -12.10900 -29.85000 1.000 24.68106 ? 106 GLU B CD  1 
ATOM   1962 O OE1 . GLU B 1 106 ? -34.67300 -11.51900 -30.26700 1.000 22.58783 ? 106 GLU B OE1 1 
ATOM   1963 O OE2 . GLU B 1 106 ? -36.80400 -12.02100 -30.39600 1.000 21.21330 ? 106 GLU B OE2 1 
ATOM   1964 N N   . MET B 1 107 ? -34.81300 -17.34800 -27.94200 1.000 26.68580 ? 107 MET B N   1 
ATOM   1965 C CA  . MET B 1 107 ? -34.59500 -18.72100 -28.37100 1.000 25.79971 ? 107 MET B CA  1 
ATOM   1966 C C   . MET B 1 107 ? -35.90300 -19.26800 -28.92600 1.000 25.24873 ? 107 MET B C   1 
ATOM   1967 O O   . MET B 1 107 ? -36.98700 -18.79800 -28.54700 1.000 24.95184 ? 107 MET B O   1 
ATOM   1968 C CB  . MET B 1 107 ? -34.12400 -19.62600 -27.22000 1.000 19.95705 ? 107 MET B CB  1 
ATOM   1969 C CG  . MET B 1 107 ? -32.76300 -19.28100 -26.57600 1.000 27.60508 ? 107 MET B CG  1 
ATOM   1970 S SD  . MET B 1 107 ? -32.87000 -19.45500 -24.76000 1.000 31.49588 ? 107 MET B SD  1 
ATOM   1971 C CE  . MET B 1 107 ? -34.22500 -18.34700 -24.36800 1.000 26.18493 ? 107 MET B CE  1 
ATOM   1972 N N   . PRO B 1 108 ? -35.84000 -20.25900 -29.81400 1.000 19.22645 ? 108 PRO B N   1 
ATOM   1973 C CA  . PRO B 1 108 ? -37.08100 -20.90600 -30.26000 1.000 19.12456 ? 108 PRO B CA  1 
ATOM   1974 C C   . PRO B 1 108 ? -37.80500 -21.53500 -29.08300 1.000 21.89161 ? 108 PRO B C   1 
ATOM   1975 O O   . PRO B 1 108 ? -37.18600 -22.08500 -28.17400 1.000 22.09328 ? 108 PRO B O   1 
ATOM   1976 C CB  . PRO B 1 108 ? -36.60100 -21.95900 -31.26800 1.000 24.08187 ? 108 PRO B CB  1 
ATOM   1977 C CG  . PRO B 1 108 ? -35.22200 -21.43500 -31.75800 1.000 25.60050 ? 108 PRO B CG  1 
ATOM   1978 C CD  . PRO B 1 108 ? -34.64100 -20.76500 -30.51500 1.000 20.77254 ? 108 PRO B CD  1 
ATOM   1979 N N   . ALA B 1 109 ? -39.13200 -21.40300 -29.08100 1.000 21.92391 ? 109 ALA B N   1 
ATOM   1980 C CA  . ALA B 1 109 ? -39.93900 -22.02600 -28.03500 1.000 23.48554 ? 109 ALA B CA  1 
ATOM   1981 C C   . ALA B 1 109 ? -39.72900 -23.53300 -28.02200 1.000 24.02255 ? 109 ALA B C   1 
ATOM   1982 O O   . ALA B 1 109 ? -39.83900 -24.17100 -26.97400 1.000 22.67648 ? 109 ALA B O   1 
ATOM   1983 C CB  . ALA B 1 109 ? -41.42800 -21.68800 -28.23600 1.000 24.89644 ? 109 ALA B CB  1 
ATOM   1984 N N   . GLN B 1 110 ? -39.41500 -24.11000 -29.18200 1.000 20.69596 ? 110 GLN B N   1 
ATOM   1985 C CA  . GLN B 1 110 ? -39.12700 -25.53500 -29.29000 1.000 26.64410 ? 110 GLN B CA  1 
ATOM   1986 C C   . GLN B 1 110 ? -37.99600 -26.00300 -28.36900 1.000 22.95514 ? 110 GLN B C   1 
ATOM   1987 O O   . GLN B 1 110 ? -37.83600 -27.20800 -28.17500 1.000 23.52950 ? 110 GLN B O   1 
ATOM   1988 C CB  . GLN B 1 110 ? -38.73700 -25.89600 -30.72400 1.000 29.90753 ? 110 GLN B CB  1 
ATOM   1989 C CG  . GLN B 1 110 ? -39.83700 -25.84900 -31.78100 1.000 37.41007 ? 110 GLN B CG  1 
ATOM   1990 C CD  . GLN B 1 110 ? -40.07800 -24.45600 -32.33600 1.000 36.62700 ? 110 GLN B CD  1 
ATOM   1991 O OE1 . GLN B 1 110 ? -39.36800 -23.49700 -32.00100 1.000 34.39153 ? 110 GLN B OE1 1 
ATOM   1992 N NE2 . GLN B 1 110 ? -41.02100 -24.35700 -33.26100 1.000 44.52546 ? 110 GLN B NE2 1 
ATOM   1993 N N   . GLN B 1 111 ? -37.14300 -25.11300 -27.87300 1.000 22.08348 ? 111 GLN B N   1 
ATOM   1994 C CA  . GLN B 1 111 ? -36.04100 -25.53600 -27.00900 1.000 24.97400 ? 111 GLN B CA  1 
ATOM   1995 C C   . GLN B 1 111 ? -36.12800 -24.84000 -25.66500 1.000 23.05472 ? 111 GLN B C   1 
ATOM   1996 O O   . GLN B 1 111 ? -35.11500 -24.48300 -25.07300 1.000 23.31468 ? 111 GLN B O   1 
ATOM   1997 C CB  . GLN B 1 111 ? -34.68200 -25.30200 -27.67500 1.000 24.65933 ? 111 GLN B CB  1 
ATOM   1998 C CG  . GLN B 1 111 ? -34.39800 -23.84500 -28.07000 1.000 20.10591 ? 111 GLN B CG  1 
ATOM   1999 C CD  . GLN B 1 111 ? -33.32900 -23.72700 -29.13700 1.000 20.30998 ? 111 GLN B CD  1 
ATOM   2000 O OE1 . GLN B 1 111 ? -33.50400 -24.19600 -30.27200 1.000 23.44408 ? 111 GLN B OE1 1 
ATOM   2001 N NE2 . GLN B 1 111 ? -32.20300 -23.10300 -28.78300 1.000 21.17498 ? 111 GLN B NE2 1 
ATOM   2002 N N   . MET B 1 112 ? -37.35700 -24.66400 -25.15700 1.000 23.18857 ? 112 MET B N   1 
ATOM   2003 C CA  . MET B 1 112 ? -37.61100 -23.84800 -23.96900 1.000 23.95821 ? 112 MET B CA  1 
ATOM   2004 C C   . MET B 1 112 ? -38.67500 -24.52300 -23.11100 1.000 28.14331 ? 112 MET B C   1 
ATOM   2005 O O   . MET B 1 112 ? -39.79700 -24.76200 -23.57700 1.000 25.08001 ? 112 MET B O   1 
ATOM   2006 C CB  . MET B 1 112 ? -38.05500 -22.45500 -24.39000 1.000 21.04444 ? 112 MET B CB  1 
ATOM   2007 C CG  . MET B 1 112 ? -36.89500 -21.54400 -24.59700 1.000 22.61002 ? 112 MET B CG  1 
ATOM   2008 S SD  . MET B 1 112 ? -37.49400 -20.02500 -25.31200 1.000 24.41569 ? 112 MET B SD  1 
ATOM   2009 C CE  . MET B 1 112 ? -37.60300 -19.02100 -23.83800 1.000 23.58380 ? 112 MET B CE  1 
ATOM   2010 N N   . VAL B 1 113 ? -38.31800 -24.84400 -21.86500 1.000 25.96250 ? 113 VAL B N   1 
ATOM   2011 C CA  . VAL B 1 113 ? -39.15800 -25.64600 -20.98700 1.000 26.38666 ? 113 VAL B CA  1 
ATOM   2012 C C   . VAL B 1 113 ? -39.45500 -24.83400 -19.73600 1.000 26.62587 ? 113 VAL B C   1 
ATOM   2013 O O   . VAL B 1 113 ? -38.53700 -24.28400 -19.11700 1.000 25.80558 ? 113 VAL B O   1 
ATOM   2014 C CB  . VAL B 1 113 ? -38.48500 -26.99300 -20.64300 1.000 23.07175 ? 113 VAL B CB  1 
ATOM   2015 C CG1 . VAL B 1 113 ? -39.27300 -27.75400 -19.58700 1.000 23.63700 ? 113 VAL B CG1 1 
ATOM   2016 C CG2 . VAL B 1 113 ? -38.32400 -27.85500 -21.89400 1.000 18.41549 ? 113 VAL B CG2 1 
ATOM   2017 N N   . GLU B 1 114 ? -40.73900 -24.74900 -19.37800 1.000 22.23224 ? 114 GLU B N   1 
ATOM   2018 C CA  . GLU B 1 114 ? -41.17400 -24.16300 -18.11300 1.000 27.90498 ? 114 GLU B CA  1 
ATOM   2019 C C   . GLU B 1 114 ? -42.16700 -25.10200 -17.44300 1.000 29.78488 ? 114 GLU B C   1 
ATOM   2020 O O   . GLU B 1 114 ? -42.98900 -25.73600 -18.11900 1.000 24.55163 ? 114 GLU B O   1 
ATOM   2021 C CB  . GLU B 1 114 ? -41.82200 -22.77100 -18.29700 1.000 26.49084 ? 114 GLU B CB  1 
ATOM   2022 C CG  . GLU B 1 114 ? -40.99600 -21.77400 -19.10600 1.000 23.08151 ? 114 GLU B CG  1 
ATOM   2023 C CD  . GLU B 1 114 ? -41.49400 -20.34200 -18.95900 1.000 27.08820 ? 114 GLU B CD  1 
ATOM   2024 O OE1 . GLU B 1 114 ? -42.57600 -20.12800 -18.35500 1.000 25.97311 ? 114 GLU B OE1 1 
ATOM   2025 O OE2 . GLU B 1 114 ? -40.78100 -19.42100 -19.41000 1.000 29.29920 ? 114 GLU B OE2 1 
ATOM   2026 N N   . TYR B 1 115 ? -42.09200 -25.17800 -16.10700 1.000 30.01133 ? 115 TYR B N   1 
ATOM   2027 C CA  . TYR B 1 115 ? -42.87900 -26.14000 -15.33000 1.000 28.85085 ? 115 TYR B CA  1 
ATOM   2028 C C   . TYR B 1 115 ? -42.80200 -27.53400 -15.95000 1.000 29.11948 ? 115 TYR B C   1 
ATOM   2029 O O   . TYR B 1 115 ? -43.77300 -28.28800 -15.92200 1.000 29.51392 ? 115 TYR B O   1 
ATOM   2030 C CB  . TYR B 1 115 ? -44.35100 -25.71300 -15.20000 1.000 24.86257 ? 115 TYR B CB  1 
ATOM   2031 C CG  . TYR B 1 115 ? -44.60000 -24.37700 -14.56900 1.000 27.92248 ? 115 TYR B CG  1 
ATOM   2032 C CD1 . TYR B 1 115 ? -44.65800 -23.22500 -15.34500 1.000 25.16733 ? 115 TYR B CD1 1 
ATOM   2033 C CD2 . TYR B 1 115 ? -44.79800 -24.25800 -13.19900 1.000 28.28959 ? 115 TYR B CD2 1 
ATOM   2034 C CE1 . TYR B 1 115 ? -44.89500 -21.99000 -14.76900 1.000 28.77435 ? 115 TYR B CE1 1 
ATOM   2035 C CE2 . TYR B 1 115 ? -45.02900 -23.03600 -12.61200 1.000 25.72056 ? 115 TYR B CE2 1 
ATOM   2036 C CZ  . TYR B 1 115 ? -45.07500 -21.89500 -13.40100 1.000 31.91577 ? 115 TYR B CZ  1 
ATOM   2037 O OH  . TYR B 1 115 ? -45.31900 -20.66000 -12.82600 1.000 27.74785 ? 115 TYR B OH  1 
ATOM   2038 N N   . GLY B 1 116 ? -41.66100 -27.88000 -16.54300 1.000 32.77036 ? 116 GLY B N   1 
ATOM   2039 C CA  . GLY B 1 116 ? -41.47800 -29.21000 -17.10000 1.000 28.89784 ? 116 GLY B CA  1 
ATOM   2040 C C   . GLY B 1 116 ? -42.12500 -29.45200 -18.44800 1.000 33.00916 ? 116 GLY B C   1 
ATOM   2041 O O   . GLY B 1 116 ? -42.10600 -30.59500 -18.92900 1.000 26.50271 ? 116 GLY B O   1 
ATOM   2042 N N   . ARG B 1 117 ? -42.69600 -28.41700 -19.07400 1.000 30.06881 ? 117 ARG B N   1 
ATOM   2043 C CA  . ARG B 1 117 ? -43.41300 -28.55400 -20.33100 1.000 34.35185 ? 117 ARG B CA  1 
ATOM   2044 C C   . ARG B 1 117 ? -42.89400 -27.55700 -21.36900 1.000 31.35563 ? 117 ARG B C   1 
ATOM   2045 O O   . ARG B 1 117 ? -42.51900 -26.41900 -21.05000 1.000 27.79215 ? 117 ARG B O   1 
ATOM   2046 C CB  . ARG B 1 117 ? -44.91300 -28.36500 -20.11600 1.000 35.25676 ? 117 ARG B CB  1 
ATOM   2047 C CG  . ARG B 1 117 ? -45.60400 -29.58600 -19.48300 1.000 40.59172 ? 117 ARG B CG  1 
ATOM   2048 C CD  . ARG B 1 117 ? -45.98100 -30.59900 -20.57800 1.000 47.45748 ? 117 ARG B CD  1 
ATOM   2049 N NE  . ARG B 1 117 ? -47.35300 -31.08500 -20.47200 1.000 61.32405 ? 117 ARG B NE  1 
ATOM   2050 C CZ  . ARG B 1 117 ? -47.75500 -32.02700 -19.63100 1.000 60.98154 ? 117 ARG B CZ  1 
ATOM   2051 N NH1 . ARG B 1 117 ? -46.91500 -32.58900 -18.78100 1.000 50.33939 ? 117 ARG B NH1 1 
ATOM   2052 N NH2 . ARG B 1 117 ? -49.02900 -32.41800 -19.65300 1.000 57.62636 ? 117 ARG B NH2 1 
ATOM   2053 N N   . PHE B 1 118 ? -42.89300 -28.00000 -22.62400 1.000 30.45953 ? 118 PHE B N   1 
ATOM   2054 C CA  . PHE B 1 118 ? -42.41900 -27.17000 -23.71900 1.000 24.87164 ? 118 PHE B CA  1 
ATOM   2055 C C   . PHE B 1 118 ? -43.36200 -25.99500 -23.94300 1.000 23.71302 ? 118 PHE B C   1 
ATOM   2056 O O   . PHE B 1 118 ? -44.58600 -26.15300 -23.98400 1.000 26.59461 ? 118 PHE B O   1 
ATOM   2057 C CB  . PHE B 1 118 ? -42.27300 -28.00800 -24.99000 1.000 25.22883 ? 118 PHE B CB  1 
ATOM   2058 C CG  . PHE B 1 118 ? -41.03500 -28.87000 -25.00100 1.000 25.62882 ? 118 PHE B CG  1 
ATOM   2059 C CD1 . PHE B 1 118 ? -39.82600 -28.37400 -25.48500 1.000 24.60387 ? 118 PHE B CD1 1 
ATOM   2060 C CD2 . PHE B 1 118 ? -41.07500 -30.17300 -24.50600 1.000 26.33420 ? 118 PHE B CD2 1 
ATOM   2061 C CE1 . PHE B 1 118 ? -38.67300 -29.16200 -25.48500 1.000 25.02189 ? 118 PHE B CE1 1 
ATOM   2062 C CE2 . PHE B 1 118 ? -39.93800 -30.96800 -24.49300 1.000 30.68717 ? 118 PHE B CE2 1 
ATOM   2063 C CZ  . PHE B 1 118 ? -38.72300 -30.45900 -24.98300 1.000 27.91159 ? 118 PHE B CZ  1 
ATOM   2064 N N   . LEU B 1 119 ? -42.77800 -24.80900 -24.06600 1.000 26.03348 ? 119 LEU B N   1 
ATOM   2065 C CA  . LEU B 1 119 ? -43.53800 -23.59300 -24.27500 1.000 24.59585 ? 119 LEU B CA  1 
ATOM   2066 C C   . LEU B 1 119 ? -44.17000 -23.58000 -25.66800 1.000 28.92087 ? 119 LEU B C   1 
ATOM   2067 O O   . LEU B 1 119 ? -43.63500 -24.16900 -26.61200 1.000 24.70536 ? 119 LEU B O   1 
ATOM   2068 C CB  . LEU B 1 119 ? -42.63100 -22.37900 -24.11900 1.000 26.61718 ? 119 LEU B CB  1 
ATOM   2069 C CG  . LEU B 1 119 ? -42.21000 -22.04600 -22.68600 1.000 29.07939 ? 119 LEU B CG  1 
ATOM   2070 C CD1 . LEU B 1 119 ? -41.44400 -20.72800 -22.66000 1.000 24.22354 ? 119 LEU B CD1 1 
ATOM   2071 C CD2 . LEU B 1 119 ? -43.45300 -22.03100 -21.75100 1.000 27.92667 ? 119 LEU B CD2 1 
ATOM   2072 N N   . PRO B 1 120 ? -45.30400 -22.90500 -25.82100 1.000 32.01807 ? 120 PRO B N   1 
ATOM   2073 C CA  . PRO B 1 120 ? -45.86500 -22.65700 -27.15000 1.000 28.97303 ? 120 PRO B CA  1 
ATOM   2074 C C   . PRO B 1 120 ? -45.23200 -21.41800 -27.78400 1.000 31.51631 ? 120 PRO B C   1 
ATOM   2075 O O   . PRO B 1 120 ? -44.49500 -20.67100 -27.13900 1.000 35.54503 ? 120 PRO B O   1 
ATOM   2076 C CB  . PRO B 1 120 ? -47.34000 -22.38100 -26.85000 1.000 28.53348 ? 120 PRO B CB  1 
ATOM   2077 C CG  . PRO B 1 120 ? -47.39000 -22.01700 -25.39200 1.000 30.72561 ? 120 PRO B CG  1 
ATOM   2078 C CD  . PRO B 1 120 ? -46.04000 -22.17200 -24.78100 1.000 25.63596 ? 120 PRO B CD  1 
ATOM   2079 N N   . GLN B 1 121 ? -45.58000 -21.18100 -29.05300 1.000 29.31594 ? 121 GLN B N   1 
ATOM   2080 C CA  . GLN B 1 121 ? -45.27700 -19.89800 -29.68100 1.000 34.29629 ? 121 GLN B CA  1 
ATOM   2081 C C   . GLN B 1 121 ? -46.07300 -18.74400 -29.04500 1.000 35.85041 ? 121 GLN B C   1 
ATOM   2082 O O   . GLN B 1 121 ? -47.17400 -18.94600 -28.52200 1.000 28.35889 ? 121 GLN B O   1 
ATOM   2083 C CB  . GLN B 1 121 ? -45.55600 -19.96100 -31.18100 1.000 33.23996 ? 121 GLN B CB  1 
ATOM   2084 C CG  . GLN B 1 121 ? -44.88900 -21.14800 -31.86500 1.000 32.66302 ? 121 GLN B CG  1 
ATOM   2085 C CD  . GLN B 1 121 ? -43.37800 -20.97500 -31.97100 1.000 37.35882 ? 121 GLN B CD  1 
ATOM   2086 O OE1 . GLN B 1 121 ? -42.86900 -19.85000 -32.03600 1.000 38.64790 ? 121 GLN B OE1 1 
ATOM   2087 N NE2 . GLN B 1 121 ? -42.65100 -22.09000 -31.93900 1.000 35.00871 ? 121 GLN B NE2 1 
ATOM   2088 N N   . PRO B 1 122 ? -45.54000 -17.51200 -29.12400 1.000 35.76076 ? 122 PRO B N   1 
ATOM   2089 C CA  . PRO B 1 122 ? -46.05300 -16.38800 -28.30300 1.000 33.87621 ? 122 PRO B CA  1 
ATOM   2090 C C   . PRO B 1 122 ? -47.52600 -15.99900 -28.48200 1.000 41.67344 ? 122 PRO B C   1 
ATOM   2091 O O   . PRO B 1 122 ? -48.00900 -15.13400 -27.73800 1.000 50.08321 ? 122 PRO B O   1 
ATOM   2092 C CB  . PRO B 1 122 ? -45.15200 -15.22600 -28.72500 1.000 32.13012 ? 122 PRO B CB  1 
ATOM   2093 C CG  . PRO B 1 122 ? -43.84300 -15.86400 -28.95200 1.000 26.99188 ? 122 PRO B CG  1 
ATOM   2094 C CD  . PRO B 1 122 ? -44.18000 -17.22600 -29.60100 1.000 34.98369 ? 122 PRO B CD  1 
ATOM   2095 N N   . GLY B 1 123 ? -48.27200 -16.54500 -29.42700 1.000 44.50784 ? 123 GLY B N   1 
ATOM   2096 C CA  . GLY B 1 123 ? -49.66500 -16.11600 -29.47400 1.000 39.47009 ? 123 GLY B CA  1 
ATOM   2097 C C   . GLY B 1 123 ? -50.61600 -17.17900 -28.97700 1.000 37.32271 ? 123 GLY B C   1 
ATOM   2098 O O   . GLY B 1 123 ? -51.82500 -16.95900 -28.88300 1.000 40.73510 ? 123 GLY B O   1 
ATOM   2099 N N   . HIS B 1 124 ? -50.06200 -18.33300 -28.62800 1.000 37.48501 ? 124 HIS B N   1 
ATOM   2100 C CA  . HIS B 1 124 ? -50.82000 -19.56200 -28.45100 1.000 35.29379 ? 124 HIS B CA  1 
ATOM   2101 C C   . HIS B 1 124 ? -50.83300 -20.01900 -26.99900 1.000 35.09841 ? 124 HIS B C   1 
ATOM   2102 O O   . HIS B 1 124 ? -51.02800 -21.20400 -26.71000 1.000 33.90762 ? 124 HIS B O   1 
ATOM   2103 C CB  . HIS B 1 124 ? -50.23500 -20.62200 -29.38200 1.000 29.84839 ? 124 HIS B CB  1 
ATOM   2104 C CG  . HIS B 1 124 ? -50.37600 -20.25900 -30.82100 1.000 40.27999 ? 124 HIS B CG  1 
ATOM   2105 N ND1 . HIS B 1 124 ? -49.45100 -19.47900 -31.48100 1.000 39.81705 ? 124 HIS B ND1 1 
ATOM   2106 C CD2 . HIS B 1 124 ? -51.34900 -20.53800 -31.72200 1.000 42.55460 ? 124 HIS B CD2 1 
ATOM   2107 C CE1 . HIS B 1 124 ? -49.84300 -19.30200 -32.72900 1.000 43.52982 ? 124 HIS B CE1 1 
ATOM   2108 N NE2 . HIS B 1 124 ? -50.98800 -19.93900 -32.90200 1.000 49.29379 ? 124 HIS B NE2 1 
ATOM   2109 N N   . GLU B 1 125 ? -50.62200 -19.07900 -26.07600 1.000 31.66751 ? 125 GLU B N   1 
ATOM   2110 C CA  . GLU B 1 125 ? -50.63100 -19.40700 -24.65700 1.000 37.69429 ? 125 GLU B CA  1 
ATOM   2111 C C   . GLU B 1 125 ? -51.99200 -19.89200 -24.18600 1.000 36.96319 ? 125 GLU B C   1 
ATOM   2112 O O   . GLU B 1 125 ? -52.05100 -20.68700 -23.24000 1.000 33.96738 ? 125 GLU B O   1 
ATOM   2113 C CB  . GLU B 1 125 ? -50.20300 -18.19700 -23.82700 1.000 34.21043 ? 125 GLU B CB  1 
ATOM   2114 C CG  . GLU B 1 125 ? -48.72500 -17.91500 -23.90100 1.000 29.89369 ? 125 GLU B CG  1 
ATOM   2115 C CD  . GLU B 1 125 ? -48.39600 -16.98000 -25.04300 1.000 35.57837 ? 125 GLU B CD  1 
ATOM   2116 O OE1 . GLU B 1 125 ? -49.34700 -16.42200 -25.63200 1.000 34.91702 ? 125 GLU B OE1 1 
ATOM   2117 O OE2 . GLU B 1 125 ? -47.19700 -16.79300 -25.34200 1.000 36.95517 ? 125 GLU B OE2 1 
ATOM   2118 N N   . GLY B 1 126 ? -53.07700 -19.45000 -24.82800 1.000 39.76297 ? 126 GLY B N   1 
ATOM   2119 C CA  . GLY B 1 126 ? -54.41500 -19.89700 -24.47500 1.000 42.47210 ? 126 GLY B CA  1 
ATOM   2120 C C   . GLY B 1 126 ? -54.65600 -21.37200 -24.72700 1.000 38.36664 ? 126 GLY B C   1 
ATOM   2121 O O   . GLY B 1 126 ? -54.99200 -22.10900 -23.79700 1.000 36.14346 ? 126 GLY B O   1 
ATOM   2122 N N   . GLU B 1 127 ? -54.48700 -21.80700 -25.97900 1.000 37.82092 ? 127 GLU B N   1 
ATOM   2123 C CA  . GLU B 1 127 ? -54.64500 -23.22200 -26.32300 1.000 44.59899 ? 127 GLU B CA  1 
ATOM   2124 C C   . GLU B 1 127 ? -53.72800 -24.09900 -25.48300 1.000 42.53196 ? 127 GLU B C   1 
ATOM   2125 O O   . GLU B 1 127 ? -54.12600 -25.16300 -24.99800 1.000 42.66854 ? 127 GLU B O   1 
ATOM   2126 C CB  . GLU B 1 127 ? -54.35300 -23.42700 -27.81500 1.000 43.26923 ? 127 GLU B CB  1 
ATOM   2127 C CG  . GLU B 1 127 ? -55.15200 -24.53700 -28.47500 1.000 56.21115 ? 127 GLU B CG  1 
ATOM   2128 C CD  . GLU B 1 127 ? -54.41000 -25.86900 -28.50400 1.000 69.47335 ? 127 GLU B CD  1 
ATOM   2129 O OE1 . GLU B 1 127 ? -53.15000 -25.84100 -28.59600 1.000 65.62237 ? 127 GLU B OE1 1 
ATOM   2130 O OE2 . GLU B 1 127 ? -55.08200 -26.94100 -28.44700 1.000 71.16254 ? 127 GLU B OE2 1 
ATOM   2131 N N   . TRP B 1 128 ? -52.48500 -23.65300 -25.30800 1.000 36.51515 ? 128 TRP B N   1 
ATOM   2132 C CA  . TRP B 1 128 ? -51.49600 -24.42600 -24.57600 1.000 35.05736 ? 128 TRP B CA  1 
ATOM   2133 C C   . TRP B 1 128 ? -51.98000 -24.72900 -23.16200 1.000 35.82080 ? 128 TRP B C   1 
ATOM   2134 O O   . TRP B 1 128 ? -51.97700 -25.88600 -22.72700 1.000 36.38799 ? 128 TRP B O   1 
ATOM   2135 C CB  . TRP B 1 128 ? -50.19300 -23.64500 -24.56900 1.000 32.96923 ? 128 TRP B CB  1 
ATOM   2136 C CG  . TRP B 1 128 ? -49.03400 -24.25300 -23.86500 1.000 33.80913 ? 128 TRP B CG  1 
ATOM   2137 C CD1 . TRP B 1 128 ? -48.11600 -25.13300 -24.38600 1.000 30.80212 ? 128 TRP B CD1 1 
ATOM   2138 C CD2 . TRP B 1 128 ? -48.60100 -23.96500 -22.53100 1.000 30.21804 ? 128 TRP B CD2 1 
ATOM   2139 N NE1 . TRP B 1 128 ? -47.15700 -25.41700 -23.44300 1.000 29.19562 ? 128 TRP B NE1 1 
ATOM   2140 C CE2 . TRP B 1 128 ? -47.43400 -24.72000 -22.29700 1.000 29.97180 ? 128 TRP B CE2 1 
ATOM   2141 C CE3 . TRP B 1 128 ? -49.09200 -23.14800 -21.50700 1.000 29.13451 ? 128 TRP B CE3 1 
ATOM   2142 C CZ2 . TRP B 1 128 ? -46.75800 -24.68900 -21.07300 1.000 33.37857 ? 128 TRP B CZ2 1 
ATOM   2143 C CZ3 . TRP B 1 128 ? -48.42100 -23.11800 -20.29100 1.000 35.17876 ? 128 TRP B CZ3 1 
ATOM   2144 C CH2 . TRP B 1 128 ? -47.26300 -23.88000 -20.08600 1.000 32.28787 ? 128 TRP B CH2 1 
ATOM   2145 N N   . PHE B 1 129 ? -52.44300 -23.69800 -22.44600 1.000 32.63736 ? 129 PHE B N   1 
ATOM   2146 C CA  . PHE B 1 129 ? -52.90200 -23.88000 -21.07300 1.000 36.16517 ? 129 PHE B CA  1 
ATOM   2147 C C   . PHE B 1 129 ? -54.14700 -24.75100 -20.99000 1.000 38.70797 ? 129 PHE B C   1 
ATOM   2148 O O   . PHE B 1 129 ? -54.39200 -25.38200 -19.95700 1.000 38.33282 ? 129 PHE B O   1 
ATOM   2149 C CB  . PHE B 1 129 ? -53.16400 -22.52200 -20.43100 1.000 35.08825 ? 129 PHE B CB  1 
ATOM   2150 C CG  . PHE B 1 129 ? -53.31600 -22.57400 -18.93800 1.000 39.14452 ? 129 PHE B CG  1 
ATOM   2151 C CD1 . PHE B 1 129 ? -52.19900 -22.71400 -18.12800 1.000 37.67433 ? 129 PHE B CD1 1 
ATOM   2152 C CD2 . PHE B 1 129 ? -54.55800 -22.43200 -18.34100 1.000 37.39341 ? 129 PHE B CD2 1 
ATOM   2153 C CE1 . PHE B 1 129 ? -52.31900 -22.75200 -16.76100 1.000 33.44339 ? 129 PHE B CE1 1 
ATOM   2154 C CE2 . PHE B 1 129 ? -54.68300 -22.46200 -16.96300 1.000 38.13684 ? 129 PHE B CE2 1 
ATOM   2155 C CZ  . PHE B 1 129 ? -53.56500 -22.61400 -16.17700 1.000 38.44402 ? 129 PHE B CZ  1 
ATOM   2156 N N   . ASP B 1 130 ? -54.93600 -24.81000 -22.05700 1.000 42.58031 ? 130 ASP B N   1 
ATOM   2157 C CA  . ASP B 1 130 ? -56.14200 -25.62500 -22.05000 1.000 46.15809 ? 130 ASP B CA  1 
ATOM   2158 C C   . ASP B 1 130 ? -55.86500 -27.10800 -22.21500 1.000 45.42450 ? 130 ASP B C   1 
ATOM   2159 O O   . ASP B 1 130 ? -56.80000 -27.90200 -22.09400 1.000 51.32358 ? 130 ASP B O   1 
ATOM   2160 C CB  . ASP B 1 130 ? -57.09900 -25.17400 -23.14900 1.000 41.88298 ? 130 ASP B CB  1 
ATOM   2161 C CG  . ASP B 1 130 ? -57.68100 -23.81700 -22.87500 1.000 48.68305 ? 130 ASP B CG  1 
ATOM   2162 O OD1 . ASP B 1 130 ? -57.76300 -23.44800 -21.68900 1.000 48.02482 ? 130 ASP B OD1 1 
ATOM   2163 O OD2 . ASP B 1 130 ? -58.04800 -23.11400 -23.83400 1.000 52.53378 ? 130 ASP B OD2 1 
ATOM   2164 N N   . ASN B 1 131 ? -54.62800 -27.50800 -22.49100 1.000 41.14808 ? 131 ASN B N   1 
ATOM   2165 C CA  . ASN B 1 131 ? -54.31200 -28.92800 -22.59700 1.000 45.10685 ? 131 ASN B CA  1 
ATOM   2166 C C   . ASN B 1 131 ? -53.23700 -29.33500 -21.61200 1.000 42.21432 ? 131 ASN B C   1 
ATOM   2167 O O   . ASN B 1 131 ? -52.41600 -30.20800 -21.88900 1.000 40.93745 ? 131 ASN B O   1 
ATOM   2168 C CB  . ASN B 1 131 ? -53.91700 -29.30100 -24.01600 1.000 46.46699 ? 131 ASN B CB  1 
ATOM   2169 C CG  . ASN B 1 131 ? -55.06300 -29.92700 -24.76600 1.000 54.03590 ? 131 ASN B CG  1 
ATOM   2170 O OD1 . ASN B 1 131 ? -55.42700 -29.47900 -25.85000 1.000 52.36256 ? 131 ASN B OD1 1 
ATOM   2171 N ND2 . ASN B 1 131 ? -55.67100 -30.95600 -24.16700 1.000 49.42121 ? 131 ASN B ND2 1 
ATOM   2172 N N   . LEU B 1 132 ? -53.23600 -28.71900 -20.44100 1.000 40.02457 ? 132 LEU B N   1 
ATOM   2173 C CA  . LEU B 1 132 ? -52.42100 -29.20000 -19.34700 1.000 39.97270 ? 132 LEU B CA  1 
ATOM   2174 C C   . LEU B 1 132 ? -53.28800 -30.00900 -18.39600 1.000 39.62141 ? 132 LEU B C   1 
ATOM   2175 O O   . LEU B 1 132 ? -54.51500 -29.87000 -18.37800 1.000 38.17120 ? 132 LEU B O   1 
ATOM   2176 C CB  . LEU B 1 132 ? -51.74800 -28.04700 -18.62200 1.000 42.29507 ? 132 LEU B CB  1 
ATOM   2177 C CG  . LEU B 1 132 ? -50.71800 -27.30500 -19.46800 1.000 44.02600 ? 132 LEU B CG  1 
ATOM   2178 C CD1 . LEU B 1 132 ? -50.22900 -26.07200 -18.72700 1.000 39.91987 ? 132 LEU B CD1 1 
ATOM   2179 C CD2 . LEU B 1 132 ? -49.55100 -28.21100 -19.81700 1.000 46.20195 ? 132 LEU B CD2 1 
ATOM   2180 N N   . SER B 1 133 ? -52.63100 -30.85200 -17.59800 1.000 44.73559 ? 133 SER B N   1 
ATOM   2181 C CA  . SER B 1 133 ? -53.32300 -31.63300 -16.58200 1.000 36.95308 ? 133 SER B CA  1 
ATOM   2182 C C   . SER B 1 133 ? -54.07000 -30.70100 -15.64000 1.000 38.91646 ? 133 SER B C   1 
ATOM   2183 O O   . SER B 1 133 ? -53.78700 -29.50200 -15.57700 1.000 34.18479 ? 133 SER B O   1 
ATOM   2184 C CB  . SER B 1 133 ? -52.33900 -32.49600 -15.79000 1.000 29.99963 ? 133 SER B CB  1 
ATOM   2185 O OG  . SER B 1 133 ? -51.76300 -31.75900 -14.73400 1.000 42.46272 ? 133 SER B OG  1 
ATOM   2186 N N   . SER B 1 134 ? -55.03500 -31.24400 -14.90800 1.000 43.50660 ? 134 SER B N   1 
ATOM   2187 C CA  . SER B 1 134 ? -55.68600 -30.47000 -13.86100 1.000 38.77059 ? 134 SER B CA  1 
ATOM   2188 C C   . SER B 1 134 ? -54.66600 -30.00100 -12.82900 1.000 37.68617 ? 134 SER B C   1 
ATOM   2189 O O   . SER B 1 134 ? -54.60600 -28.81200 -12.49700 1.000 35.57051 ? 134 SER B O   1 
ATOM   2190 C CB  . SER B 1 134 ? -56.77800 -31.31600 -13.20400 1.000 38.45874 ? 134 SER B CB  1 
ATOM   2191 O OG  . SER B 1 134 ? -58.02100 -31.11600 -13.84300 1.000 45.41750 ? 134 SER B OG  1 
ATOM   2192 N N   . ASP B 1 135 ? -53.84700 -30.93000 -12.31900 1.000 36.30346 ? 135 ASP B N   1 
ATOM   2193 C CA  . ASP B 1 135 ? -52.81100 -30.57100 -11.35500 1.000 40.53396 ? 135 ASP B CA  1 
ATOM   2194 C C   . ASP B 1 135 ? -51.89600 -29.48000 -11.90300 1.000 41.71163 ? 135 ASP B C   1 
ATOM   2195 O O   . ASP B 1 135 ? -51.63000 -28.48100 -11.22500 1.000 38.37738 ? 135 ASP B O   1 
ATOM   2196 C CB  . ASP B 1 135 ? -52.00400 -31.81500 -10.96500 1.000 40.02928 ? 135 ASP B CB  1 
ATOM   2197 C CG  . ASP B 1 135 ? -52.87400 -32.91900 -10.36200 1.000 46.05457 ? 135 ASP B CG  1 
ATOM   2198 O OD1 . ASP B 1 135 ? -54.04300 -32.64300 -10.01000 1.000 42.25877 ? 135 ASP B OD1 1 
ATOM   2199 O OD2 . ASP B 1 135 ? -52.39500 -34.06300 -10.25200 1.000 54.88496 ? 135 ASP B OD2 1 
ATOM   2200 N N   . GLU B 1 136 ? -51.43600 -29.63400 -13.14300 1.000 37.20536 ? 136 GLU B N   1 
ATOM   2201 C CA  . GLU B 1 136 ? -50.49300 -28.67000 -13.69700 1.000 36.83217 ? 136 GLU B CA  1 
ATOM   2202 C C   . GLU B 1 136 ? -51.10500 -27.27800 -13.76300 1.000 33.87312 ? 136 GLU B C   1 
ATOM   2203 O O   . GLU B 1 136 ? -50.43100 -26.28600 -13.46600 1.000 35.63151 ? 136 GLU B O   1 
ATOM   2204 C CB  . GLU B 1 136 ? -50.03100 -29.13200 -15.07800 1.000 35.64750 ? 136 GLU B CB  1 
ATOM   2205 C CG  . GLU B 1 136 ? -48.94300 -30.18200 -15.03000 1.000 38.42439 ? 136 GLU B CG  1 
ATOM   2206 C CD  . GLU B 1 136 ? -48.60600 -30.70200 -16.40000 1.000 45.42237 ? 136 GLU B CD  1 
ATOM   2207 O OE1 . GLU B 1 136 ? -49.34600 -31.57100 -16.90000 1.000 50.95591 ? 136 GLU B OE1 1 
ATOM   2208 O OE2 . GLU B 1 136 ? -47.62400 -30.22200 -16.98400 1.000 49.03991 ? 136 GLU B OE2 1 
ATOM   2209 N N   . ARG B 1 137 ? -52.38000 -27.18000 -14.14400 1.000 31.00800 ? 137 ARG B N   1 
ATOM   2210 C CA  . ARG B 1 137 ? -53.01800 -25.87000 -14.18500 1.000 32.95466 ? 137 ARG B CA  1 
ATOM   2211 C C   . ARG B 1 137 ? -53.15000 -25.29400 -12.78100 1.000 39.95394 ? 137 ARG B C   1 
ATOM   2212 O O   . ARG B 1 137 ? -52.89600 -24.10200 -12.57000 1.000 33.95156 ? 137 ARG B O   1 
ATOM   2213 C CB  . ARG B 1 137 ? -54.38000 -25.96700 -14.87600 1.000 38.19517 ? 137 ARG B CB  1 
ATOM   2214 C CG  . ARG B 1 137 ? -54.30100 -26.57800 -16.27600 1.000 42.86641 ? 137 ARG B CG  1 
ATOM   2215 C CD  . ARG B 1 137 ? -55.68000 -26.76000 -16.90400 1.000 40.43559 ? 137 ARG B CD  1 
ATOM   2216 N NE  . ARG B 1 137 ? -56.33200 -25.48400 -17.15400 1.000 49.51638 ? 137 ARG B NE  1 
ATOM   2217 C CZ  . ARG B 1 137 ? -57.61500 -25.24600 -16.92500 1.000 52.71786 ? 137 ARG B CZ  1 
ATOM   2218 N NH1 . ARG B 1 137 ? -58.41200 -26.17700 -16.42300 1.000 65.91921 ? 137 ARG B NH1 1 
ATOM   2219 N NH2 . ARG B 1 137 ? -58.11100 -24.04200 -17.19900 1.000 49.86849 ? 137 ARG B NH2 1 
ATOM   2220 N N   . ALA B 1 138 ? -53.46900 -26.15000 -11.80200 1.000 35.26174 ? 138 ALA B N   1 
ATOM   2221 C CA  . ALA B 1 138 ? -53.63200 -25.70300 -10.42400 1.000 34.62155 ? 138 ALA B CA  1 
ATOM   2222 C C   . ALA B 1 138 ? -52.30900 -25.22300 -9.82900  1.000 37.51103 ? 138 ALA B C   1 
ATOM   2223 O O   . ALA B 1 138 ? -52.25400 -24.14900 -9.21400  1.000 37.25353 ? 138 ALA B O   1 
ATOM   2224 C CB  . ALA B 1 138 ? -54.22500 -26.83200 -9.58300  1.000 36.39289 ? 138 ALA B CB  1 
ATOM   2225 N N   . PHE B 1 139 ? -51.23100 -26.01100 -9.98600  1.000 33.28886 ? 139 PHE B N   1 
ATOM   2226 C CA  . PHE B 1 139 ? -49.93200 -25.55900 -9.49800  1.000 34.60639 ? 139 PHE B CA  1 
ATOM   2227 C C   . PHE B 1 139 ? -49.55800 -24.22700 -10.14100 1.000 41.32826 ? 139 PHE B C   1 
ATOM   2228 O O   . PHE B 1 139 ? -48.97000 -23.35100 -9.49400  1.000 41.48065 ? 139 PHE B O   1 
ATOM   2229 C CB  . PHE B 1 139 ? -48.85700 -26.61900 -9.77000  1.000 37.89135 ? 139 PHE B CB  1 
ATOM   2230 C CG  . PHE B 1 139 ? -47.46300 -26.20600 -9.34100  1.000 43.35731 ? 139 PHE B CG  1 
ATOM   2231 C CD1 . PHE B 1 139 ? -47.08100 -26.29300 -8.00900  1.000 50.73746 ? 139 PHE B CD1 1 
ATOM   2232 C CD2 . PHE B 1 139 ? -46.53300 -25.74700 -10.26400 1.000 40.88354 ? 139 PHE B CD2 1 
ATOM   2233 C CE1 . PHE B 1 139 ? -45.80500 -25.90800 -7.60100  1.000 48.53747 ? 139 PHE B CE1 1 
ATOM   2234 C CE2 . PHE B 1 139 ? -45.25500 -25.35900 -9.86200  1.000 37.53284 ? 139 PHE B CE2 1 
ATOM   2235 C CZ  . PHE B 1 139 ? -44.89600 -25.43900 -8.53200  1.000 44.81946 ? 139 PHE B CZ  1 
ATOM   2236 N N   . MET B 1 140 ? -49.94100 -24.04800 -11.40300 1.000 34.35876 ? 140 MET B N   1 
ATOM   2237 C CA  . MET B 1 140 ? -49.56700 -22.86400 -12.16000 1.000 36.85585 ? 140 MET B CA  1 
ATOM   2238 C C   . MET B 1 140 ? -50.38900 -21.65200 -11.72800 1.000 41.65857 ? 140 MET B C   1 
ATOM   2239 O O   . MET B 1 140 ? -49.84700 -20.54800 -11.58000 1.000 38.55964 ? 140 MET B O   1 
ATOM   2240 C CB  . MET B 1 140 ? -49.75700 -23.16600 -13.65000 1.000 38.42950 ? 140 MET B CB  1 
ATOM   2241 C CG  . MET B 1 140 ? -48.55800 -22.91300 -14.53400 1.000 35.85550 ? 140 MET B CG  1 
ATOM   2242 S SD  . MET B 1 140 ? -48.69500 -23.71200 -16.14900 1.000 33.70453 ? 140 MET B SD  1 
ATOM   2243 C CE  . MET B 1 140 ? -48.42300 -25.44200 -15.76900 1.000 36.29215 ? 140 MET B CE  1 
ATOM   2244 N N   . GLU B 1 141 ? -51.69500 -21.84200 -11.51700 1.000 37.93855 ? 141 GLU B N   1 
ATOM   2245 C CA  . GLU B 1 141 ? -52.56800 -20.75700 -11.07900 1.000 38.52991 ? 141 GLU B CA  1 
ATOM   2246 C C   . GLU B 1 141 ? -52.12100 -20.15800 -9.75000  1.000 42.86729 ? 141 GLU B C   1 
ATOM   2247 O O   . GLU B 1 141 ? -52.34700 -18.96600 -9.50400  1.000 42.00800 ? 141 GLU B O   1 
ATOM   2248 C CB  . GLU B 1 141 ? -54.00400 -21.27400 -10.96500 1.000 43.43945 ? 141 GLU B CB  1 
ATOM   2249 C CG  . GLU B 1 141 ? -54.55500 -21.83500 -12.26700 1.000 46.27802 ? 141 GLU B CG  1 
ATOM   2250 C CD  . GLU B 1 141 ? -55.95900 -21.42100 -12.56800 1.000 54.55512 ? 141 GLU B CD  1 
ATOM   2251 O OE1 . GLU B 1 141 ? -56.63800 -20.89400 -11.65800 1.000 67.32997 ? 141 GLU B OE1 1 
ATOM   2252 O OE2 . GLU B 1 141 ? -56.39600 -21.66300 -13.71600 1.000 56.35514 ? 141 GLU B OE2 1 
ATOM   2253 N N   . THR B 1 142 ? -51.48200 -20.95200 -8.88200  1.000 41.04160 ? 142 THR B N   1 
ATOM   2254 C CA  . THR B 1 142 ? -51.05400 -20.39300 -7.60000  1.000 45.38344 ? 142 THR B CA  1 
ATOM   2255 C C   . THR B 1 142 ? -49.88800 -19.40800 -7.73100  1.000 37.13436 ? 142 THR B C   1 
ATOM   2256 O O   . THR B 1 142 ? -49.50600 -18.79100 -6.73700  1.000 37.70990 ? 142 THR B O   1 
ATOM   2257 C CB  . THR B 1 142 ? -50.67400 -21.50900 -6.60300  1.000 43.13818 ? 142 THR B CB  1 
ATOM   2258 O OG1 . THR B 1 142 ? -49.36300 -22.01700 -6.89200  1.000 44.79934 ? 142 THR B OG1 1 
ATOM   2259 C CG2 . THR B 1 142 ? -51.69700 -22.65300 -6.61200  1.000 36.69798 ? 142 THR B CG2 1 
ATOM   2260 N N   . ASN B 1 143 ? -49.30600 -19.24400 -8.91200  1.000 39.61348 ? 143 ASN B N   1 
ATOM   2261 C CA  . ASN B 1 143 ? -48.17100 -18.34300 -9.07500  1.000 37.21691 ? 143 ASN B CA  1 
ATOM   2262 C C   . ASN B 1 143 ? -48.60200 -17.08600 -9.81100  1.000 34.36833 ? 143 ASN B C   1 
ATOM   2263 O O   . ASN B 1 143 ? -48.02500 -16.72800 -10.84300 1.000 36.55574 ? 143 ASN B O   1 
ATOM   2264 C CB  . ASN B 1 143 ? -47.02700 -19.05600 -9.81200  1.000 38.46647 ? 143 ASN B CB  1 
ATOM   2265 C CG  . ASN B 1 143 ? -46.34800 -20.09200 -8.94200  1.000 33.96263 ? 143 ASN B CG  1 
ATOM   2266 O OD1 . ASN B 1 143 ? -46.29600 -19.93800 -7.72600  1.000 33.65075 ? 143 ASN B OD1 1 
ATOM   2267 N ND2 . ASN B 1 143 ? -45.83200 -21.15300 -9.55400  1.000 31.98299 ? 143 ASN B ND2 1 
ATOM   2268 N N   . VAL B 1 144 ? -49.63100 -16.41800 -9.29700  1.000 35.05918 ? 144 VAL B N   1 
ATOM   2269 C CA  . VAL B 1 144 ? -50.13500 -15.17700 -9.86600  1.000 35.01677 ? 144 VAL B CA  1 
ATOM   2270 C C   . VAL B 1 144 ? -50.31900 -14.17400 -8.73500  1.000 39.90389 ? 144 VAL B C   1 
ATOM   2271 O O   . VAL B 1 144 ? -50.96900 -14.48100 -7.72900  1.000 41.88348 ? 144 VAL B O   1 
ATOM   2272 C CB  . VAL B 1 144 ? -51.46000 -15.38400 -10.62600 1.000 38.23051 ? 144 VAL B CB  1 
ATOM   2273 C CG1 . VAL B 1 144 ? -51.91600 -14.07100 -11.23700 1.000 39.21783 ? 144 VAL B CG1 1 
ATOM   2274 C CG2 . VAL B 1 144 ? -51.31700 -16.44500 -11.70600 1.000 34.02400 ? 144 VAL B CG2 1 
ATOM   2275 N N   . ASP B 1 145 ? -49.74600 -12.98400 -8.90800  1.000 44.06057 ? 145 ASP B N   1 
ATOM   2276 C CA  . ASP B 1 145 ? -49.82100 -11.87100 -7.95900  1.000 44.83990 ? 145 ASP B CA  1 
ATOM   2277 C C   . ASP B 1 145 ? -50.35200 -10.62700 -8.68600  1.000 49.30301 ? 145 ASP B C   1 
ATOM   2278 O O   . ASP B 1 145 ? -51.56800 -10.42800 -8.81500  1.000 52.79390 ? 145 ASP B O   1 
ATOM   2279 C CB  . ASP B 1 145 ? -48.43300 -11.59000 -7.34600  1.000 45.69009 ? 145 ASP B CB  1 
ATOM   2280 C CG  . ASP B 1 145 ? -48.46100 -10.50000 -6.26000  1.000 47.06281 ? 145 ASP B CG  1 
ATOM   2281 O OD1 . ASP B 1 145 ? -48.74200 -9.32400  -6.57200  1.000 52.75804 ? 145 ASP B OD1 1 
ATOM   2282 O OD2 . ASP B 1 145 ? -48.16300 -10.80700 -5.09200  1.000 50.62519 ? 145 ASP B OD2 1 
ATOM   2283 N N   . PRO C 1 1   ? -20.40100 -27.83900 -23.96800 1.000 32.15518 ? 1   PRO C N   1 
ATOM   2284 C CA  . PRO C 1 1   ? -21.38000 -26.81700 -23.58100 1.000 26.20574 ? 1   PRO C CA  1 
ATOM   2285 C C   . PRO C 1 1   ? -21.11100 -26.30400 -22.17000 1.000 28.81287 ? 1   PRO C C   1 
ATOM   2286 O O   . PRO C 1 1   ? -20.24100 -26.85200 -21.47900 1.000 28.23136 ? 1   PRO C O   1 
ATOM   2287 C CB  . PRO C 1 1   ? -22.70900 -27.58000 -23.64100 1.000 25.34189 ? 1   PRO C CB  1 
ATOM   2288 C CG  . PRO C 1 1   ? -22.33000 -28.97500 -23.21200 1.000 26.36981 ? 1   PRO C CG  1 
ATOM   2289 C CD  . PRO C 1 1   ? -20.94900 -29.20600 -23.82100 1.000 32.96506 ? 1   PRO C CD  1 
ATOM   2290 N N   . VAL C 1 2   ? -21.84600 -25.27700 -21.74500 1.000 24.28342 ? 2   VAL C N   1 
ATOM   2291 C CA  . VAL C 1 2   ? -21.94100 -24.91300 -20.34100 1.000 23.33898 ? 2   VAL C CA  1 
ATOM   2292 C C   . VAL C 1 2   ? -23.41300 -24.92600 -19.95700 1.000 24.86467 ? 2   VAL C C   1 
ATOM   2293 O O   . VAL C 1 2   ? -24.25300 -24.31600 -20.63000 1.000 23.99787 ? 2   VAL C O   1 
ATOM   2294 C CB  . VAL C 1 2   ? -21.30300 -23.54600 -20.02500 1.000 22.85942 ? 2   VAL C CB  1 
ATOM   2295 C CG1 . VAL C 1 2   ? -21.49100 -23.22700 -18.55000 1.000 21.03795 ? 2   VAL C CG1 1 
ATOM   2296 C CG2 . VAL C 1 2   ? -19.82100 -23.52900 -20.39300 1.000 22.80933 ? 2   VAL C CG2 1 
ATOM   2297 N N   . TYR C 1 3   ? -23.72200 -25.64600 -18.89900 1.000 24.68758 ? 3   TYR C N   1 
ATOM   2298 C CA  . TYR C 1 3   ? -25.03500 -25.61800 -18.27900 1.000 23.92579 ? 3   TYR C CA  1 
ATOM   2299 C C   . TYR C 1 3   ? -24.93600 -24.78100 -17.00800 1.000 24.14631 ? 3   TYR C C   1 
ATOM   2300 O O   . TYR C 1 3   ? -24.31800 -25.20600 -16.02100 1.000 22.39682 ? 3   TYR C O   1 
ATOM   2301 C CB  . TYR C 1 3   ? -25.50600 -27.03900 -17.98800 1.000 22.79764 ? 3   TYR C CB  1 
ATOM   2302 C CG  . TYR C 1 3   ? -25.89800 -27.81600 -19.22900 1.000 23.11553 ? 3   TYR C CG  1 
ATOM   2303 C CD1 . TYR C 1 3   ? -27.18700 -27.74900 -19.72100 1.000 23.91515 ? 3   TYR C CD1 1 
ATOM   2304 C CD2 . TYR C 1 3   ? -24.97500 -28.60700 -19.90400 1.000 22.86427 ? 3   TYR C CD2 1 
ATOM   2305 C CE1 . TYR C 1 3   ? -27.55800 -28.44800 -20.84000 1.000 26.94649 ? 3   TYR C CE1 1 
ATOM   2306 C CE2 . TYR C 1 3   ? -25.33100 -29.31700 -21.02600 1.000 22.86499 ? 3   TYR C CE2 1 
ATOM   2307 C CZ  . TYR C 1 3   ? -26.63500 -29.23200 -21.49200 1.000 25.43804 ? 3   TYR C CZ  1 
ATOM   2308 O OH  . TYR C 1 3   ? -27.04300 -29.91900 -22.61200 1.000 24.84116 ? 3   TYR C OH  1 
ATOM   2309 N N   . MET C 1 4   ? -25.50500 -23.57500 -17.04300 1.000 23.99972 ? 4   MET C N   1 
ATOM   2310 C CA  . MET C 1 4   ? -25.70300 -22.79500 -15.82600 1.000 23.61154 ? 4   MET C CA  1 
ATOM   2311 C C   . MET C 1 4   ? -26.93000 -23.34400 -15.11200 1.000 24.37417 ? 4   MET C C   1 
ATOM   2312 O O   . MET C 1 4   ? -28.00200 -23.44500 -15.71600 1.000 22.63486 ? 4   MET C O   1 
ATOM   2313 C CB  . MET C 1 4   ? -25.90500 -21.31100 -16.13600 1.000 20.74681 ? 4   MET C CB  1 
ATOM   2314 C CG  . MET C 1 4   ? -24.80300 -20.64400 -16.96200 1.000 24.09535 ? 4   MET C CG  1 
ATOM   2315 S SD  . MET C 1 4   ? -23.14300 -20.94000 -16.32800 1.000 29.95209 ? 4   MET C SD  1 
ATOM   2316 C CE  . MET C 1 4   ? -23.15000 -19.94900 -14.84500 1.000 25.02224 ? 4   MET C CE  1 
ATOM   2317 N N   . VAL C 1 5   ? -26.78200 -23.73100 -13.84300 1.000 21.99377 ? 5   VAL C N   1 
ATOM   2318 C CA  . VAL C 1 5   ? -27.88000 -24.34500 -13.09400 1.000 19.98299 ? 5   VAL C CA  1 
ATOM   2319 C C   . VAL C 1 5   ? -28.17300 -23.48700 -11.87400 1.000 25.27152 ? 5   VAL C C   1 
ATOM   2320 O O   . VAL C 1 5   ? -27.39500 -23.48300 -10.90700 1.000 23.87424 ? 5   VAL C O   1 
ATOM   2321 C CB  . VAL C 1 5   ? -27.58000 -25.79300 -12.68500 1.000 22.44312 ? 5   VAL C CB  1 
ATOM   2322 C CG1 . VAL C 1 5   ? -28.74900 -26.35600 -11.88700 1.000 23.73332 ? 5   VAL C CG1 1 
ATOM   2323 C CG2 . VAL C 1 5   ? -27.32500 -26.66600 -13.90900 1.000 21.44803 ? 5   VAL C CG2 1 
ATOM   2324 N N   . TYR C 1 6   ? -29.32200 -22.79600 -11.90000 1.000 24.60842 ? 6   TYR C N   1 
ATOM   2325 C CA  . TYR C 1 6   ? -29.70600 -21.85400 -10.85200 1.000 25.25984 ? 6   TYR C CA  1 
ATOM   2326 C C   . TYR C 1 6   ? -30.58500 -22.56500 -9.83400  1.000 26.10692 ? 6   TYR C C   1 
ATOM   2327 O O   . TYR C 1 6   ? -31.68500 -23.02600 -10.16000 1.000 27.76066 ? 6   TYR C O   1 
ATOM   2328 C CB  . TYR C 1 6   ? -30.40100 -20.63700 -11.46100 1.000 24.28215 ? 6   TYR C CB  1 
ATOM   2329 C CG  . TYR C 1 6   ? -29.50000 -19.94700 -12.44700 1.000 27.21102 ? 6   TYR C CG  1 
ATOM   2330 C CD1 . TYR C 1 6   ? -29.48900 -20.31800 -13.80100 1.000 25.48668 ? 6   TYR C CD1 1 
ATOM   2331 C CD2 . TYR C 1 6   ? -28.59300 -18.98000 -12.01700 1.000 27.71163 ? 6   TYR C CD2 1 
ATOM   2332 C CE1 . TYR C 1 6   ? -28.62300 -19.68500 -14.72100 1.000 21.59247 ? 6   TYR C CE1 1 
ATOM   2333 C CE2 . TYR C 1 6   ? -27.71800 -18.34600 -12.92300 1.000 26.44546 ? 6   TYR C CE2 1 
ATOM   2334 C CZ  . TYR C 1 6   ? -27.74300 -18.70600 -14.27500 1.000 28.08941 ? 6   TYR C CZ  1 
ATOM   2335 O OH  . TYR C 1 6   ? -26.87200 -18.08400 -15.15900 1.000 26.75765 ? 6   TYR C OH  1 
ATOM   2336 N N   . VAL C 1 7   ? -30.07900 -22.67600 -8.60500  1.000 25.88425 ? 7   VAL C N   1 
ATOM   2337 C CA  . VAL C 1 7   ? -30.77000 -23.37700 -7.53700  1.000 26.32735 ? 7   VAL C CA  1 
ATOM   2338 C C   . VAL C 1 7   ? -30.72100 -22.52600 -6.27300  1.000 29.24592 ? 7   VAL C C   1 
ATOM   2339 O O   . VAL C 1 7   ? -29.98400 -21.54400 -6.17300  1.000 24.16640 ? 7   VAL C O   1 
ATOM   2340 C CB  . VAL C 1 7   ? -30.17100 -24.78800 -7.28200  1.000 27.40795 ? 7   VAL C CB  1 
ATOM   2341 C CG1 . VAL C 1 7   ? -30.45800 -25.70300 -8.49500  1.000 26.01335 ? 7   VAL C CG1 1 
ATOM   2342 C CG2 . VAL C 1 7   ? -28.66600 -24.71400 -6.99000  1.000 22.74983 ? 7   VAL C CG2 1 
ATOM   2343 N N   . SER C 1 8   ? -31.54700 -22.91300 -5.31300  1.000 32.63480 ? 8   SER C N   1 
ATOM   2344 C CA  . SER C 1 8   ? -31.57700 -22.25300 -4.01800  1.000 37.78122 ? 8   SER C CA  1 
ATOM   2345 C C   . SER C 1 8   ? -30.49000 -22.83600 -3.11900  1.000 34.10741 ? 8   SER C C   1 
ATOM   2346 O O   . SER C 1 8   ? -30.18200 -24.03300 -3.19300  1.000 35.13608 ? 8   SER C O   1 
ATOM   2347 C CB  . SER C 1 8   ? -32.95900 -22.43400 -3.37100  1.000 32.25195 ? 8   SER C CB  1 
ATOM   2348 O OG  . SER C 1 8   ? -33.94000 -21.70500 -4.08500  1.000 31.79261 ? 8   SER C OG  1 
ATOM   2349 N N   . GLN C 1 9   ? -29.89000 -21.97900 -2.28700  1.000 24.16178 ? 9   GLN C N   1 
ATOM   2350 C CA  . GLN C 1 9   ? -28.89700 -22.47500 -1.34800  1.000 36.27116 ? 9   GLN C CA  1 
ATOM   2351 C C   . GLN C 1 9   ? -29.51100 -23.55300 -0.46100  1.000 36.62148 ? 9   GLN C C   1 
ATOM   2352 O O   . GLN C 1 9   ? -30.67000 -23.45600 -0.05700  1.000 35.71209 ? 9   GLN C O   1 
ATOM   2353 C CB  . GLN C 1 9   ? -28.33800 -21.35000 -0.47800  1.000 34.53387 ? 9   GLN C CB  1 
ATOM   2354 C CG  . GLN C 1 9   ? -27.17600 -20.57800 -1.09400  1.000 35.05157 ? 9   GLN C CG  1 
ATOM   2355 C CD  . GLN C 1 9   ? -27.13000 -19.11100 -0.65500  1.000 42.64783 ? 9   GLN C CD  1 
ATOM   2356 O OE1 . GLN C 1 9   ? -26.60600 -18.25100 -1.37500  1.000 41.92092 ? 9   GLN C OE1 1 
ATOM   2357 N NE2 . GLN C 1 9   ? -27.66800 -18.82600 0.53500   1.000 38.51595 ? 9   GLN C NE2 1 
ATOM   2358 N N   . ASP C 1 10  ? -28.72500 -24.59300 -0.18300  1.000 35.87639 ? 10  ASP C N   1 
ATOM   2359 C CA  . ASP C 1 10  ? -29.06700 -25.69900 0.70500   1.000 39.21129 ? 10  ASP C CA  1 
ATOM   2360 C C   . ASP C 1 10  ? -30.18600 -26.56000 0.18000   1.000 42.19065 ? 10  ASP C C   1 
ATOM   2361 O O   . ASP C 1 10  ? -30.79200 -27.30300 0.94900   1.000 52.13135 ? 10  ASP C O   1 
ATOM   2362 C CB  . ASP C 1 10  ? -29.42800 -25.22800 2.11500   1.000 40.90567 ? 10  ASP C CB  1 
ATOM   2363 C CG  . ASP C 1 10  ? -28.34900 -24.38400 2.72800   1.000 50.92124 ? 10  ASP C CG  1 
ATOM   2364 O OD1 . ASP C 1 10  ? -27.16800 -24.80000 2.66700   1.000 57.83036 ? 10  ASP C OD1 1 
ATOM   2365 O OD2 . ASP C 1 10  ? -28.68300 -23.31500 3.28600   1.000 55.01833 ? 10  ASP C OD2 1 
ATOM   2366 N N   . ARG C 1 11  ? -30.49800 -26.47800 -1.10700  1.000 38.42636 ? 11  ARG C N   1 
ATOM   2367 C CA  . ARG C 1 11  ? -31.52300 -27.37700 -1.60200  1.000 35.81651 ? 11  ARG C CA  1 
ATOM   2368 C C   . ARG C 1 11  ? -30.91300 -28.70100 -2.06500  1.000 41.31203 ? 11  ARG C C   1 
ATOM   2369 O O   . ARG C 1 11  ? -31.46300 -29.76700 -1.77600  1.000 44.33836 ? 11  ARG C O   1 
ATOM   2370 C CB  . ARG C 1 11  ? -32.31600 -26.70400 -2.72200  1.000 38.21684 ? 11  ARG C CB  1 
ATOM   2371 C CG  . ARG C 1 11  ? -33.46800 -27.54200 -3.22500  1.000 42.46661 ? 11  ARG C CG  1 
ATOM   2372 C CD  . ARG C 1 11  ? -34.44600 -27.79900 -2.08600  1.000 40.41767 ? 11  ARG C CD  1 
ATOM   2373 N NE  . ARG C 1 11  ? -35.70900 -28.33800 -2.56600  1.000 40.36333 ? 11  ARG C NE  1 
ATOM   2374 C CZ  . ARG C 1 11  ? -35.90800 -29.62300 -2.82000  1.000 49.10807 ? 11  ARG C CZ  1 
ATOM   2375 N NH1 . ARG C 1 11  ? -34.95300 -30.51600 -2.62500  1.000 49.96466 ? 11  ARG C NH1 1 
ATOM   2376 N NH2 . ARG C 1 11  ? -37.09200 -30.01900 -3.28300  1.000 50.35738 ? 11  ARG C NH2 1 
ATOM   2377 N N   . LEU C 1 12  ? -29.77400 -28.66000 -2.76000  1.000 38.23377 ? 12  LEU C N   1 
ATOM   2378 C CA  . LEU C 1 12  ? -29.04800 -29.85300 -3.17700  1.000 39.13708 ? 12  LEU C CA  1 
ATOM   2379 C C   . LEU C 1 12  ? -27.79700 -30.01600 -2.32100  1.000 37.31496 ? 12  LEU C C   1 
ATOM   2380 O O   . LEU C 1 12  ? -26.94200 -29.12600 -2.29600  1.000 39.56334 ? 12  LEU C O   1 
ATOM   2381 C CB  . LEU C 1 12  ? -28.65000 -29.77400 -4.65400  1.000 39.04853 ? 12  LEU C CB  1 
ATOM   2382 C CG  . LEU C 1 12  ? -29.74800 -29.72600 -5.72300  1.000 41.02636 ? 12  LEU C CG  1 
ATOM   2383 C CD1 . LEU C 1 12  ? -30.99000 -30.51900 -5.27700  1.000 37.52776 ? 12  LEU C CD1 1 
ATOM   2384 C CD2 . LEU C 1 12  ? -30.09900 -28.29300 -6.11400  1.000 45.85041 ? 12  LEU C CD2 1 
ATOM   2385 N N   . THR C 1 13  ? -27.67300 -31.16000 -1.65900  1.000 34.31899 ? 13  THR C N   1 
ATOM   2386 C CA  . THR C 1 13  ? -26.44200 -31.52700 -0.97700  1.000 34.67461 ? 13  THR C CA  1 
ATOM   2387 C C   . THR C 1 13  ? -25.29600 -31.67000 -1.98100  1.000 41.22117 ? 13  THR C C   1 
ATOM   2388 O O   . THR C 1 13  ? -25.53900 -31.73000 -3.19100  1.000 36.70069 ? 13  THR C O   1 
ATOM   2389 C CB  . THR C 1 13  ? -26.64500 -32.82400 -0.18900  1.000 38.92460 ? 13  THR C CB  1 
ATOM   2390 O OG1 . THR C 1 13  ? -27.20200 -33.82900 -1.04600  1.000 36.12302 ? 13  THR C OG1 1 
ATOM   2391 C CG2 . THR C 1 13  ? -27.59000 -32.59200 0.99800   1.000 36.38029 ? 13  THR C CG2 1 
ATOM   2392 N N   . PRO C 1 14  ? -24.03400 -31.71300 -1.53000  1.000 41.25228 ? 14  PRO C N   1 
ATOM   2393 C CA  . PRO C 1 14  ? -22.93600 -31.97100 -2.47600  1.000 37.38992 ? 14  PRO C CA  1 
ATOM   2394 C C   . PRO C 1 14  ? -23.15200 -33.19000 -3.35500  1.000 39.63889 ? 14  PRO C C   1 
ATOM   2395 O O   . PRO C 1 14  ? -22.83700 -33.14900 -4.55100  1.000 37.93992 ? 14  PRO C O   1 
ATOM   2396 C CB  . PRO C 1 14  ? -21.73800 -32.14800 -1.54400  1.000 38.18316 ? 14  PRO C CB  1 
ATOM   2397 C CG  . PRO C 1 14  ? -22.05300 -31.27200 -0.39400  1.000 36.33953 ? 14  PRO C CG  1 
ATOM   2398 C CD  . PRO C 1 14  ? -23.52100 -31.42700 -0.17300  1.000 40.30974 ? 14  PRO C CD  1 
ATOM   2399 N N   . SER C 1 15  ? -23.67100 -34.28200 -2.79800  1.000 35.75152 ? 15  SER C N   1 
ATOM   2400 C CA  . SER C 1 15  ? -23.85800 -35.48400 -3.60300  1.000 37.97289 ? 15  SER C CA  1 
ATOM   2401 C C   . SER C 1 15  ? -25.00200 -35.30800 -4.59500  1.000 36.94149 ? 15  SER C C   1 
ATOM   2402 O O   . SER C 1 15  ? -24.94200 -35.81600 -5.72100  1.000 42.43655 ? 15  SER C O   1 
ATOM   2403 C CB  . SER C 1 15  ? -24.12400 -36.67400 -2.69700  1.000 37.24013 ? 15  SER C CB  1 
ATOM   2404 O OG  . SER C 1 15  ? -25.10000 -36.30000 -1.74600  1.000 48.52930 ? 15  SER C OG  1 
ATOM   2405 N N   . ALA C 1 16  ? -26.05100 -34.58700 -4.19300  1.000 34.94399 ? 16  ALA C N   1 
ATOM   2406 C CA  . ALA C 1 16  ? -27.13000 -34.27000 -5.11900  1.000 36.49434 ? 16  ALA C CA  1 
ATOM   2407 C C   . ALA C 1 16  ? -26.65700 -33.34900 -6.23700  1.000 37.41484 ? 16  ALA C C   1 
ATOM   2408 O O   . ALA C 1 16  ? -27.16600 -33.43400 -7.36200  1.000 35.13934 ? 16  ALA C O   1 
ATOM   2409 C CB  . ALA C 1 16  ? -28.30400 -33.65500 -4.36900  1.000 38.22359 ? 16  ALA C CB  1 
ATOM   2410 N N   . LYS C 1 17  ? -25.69000 -32.47100 -5.95200  1.000 36.56299 ? 17  LYS C N   1 
ATOM   2411 C CA  . LYS C 1 17  ? -25.09400 -31.64700 -7.00100  1.000 33.19229 ? 17  LYS C CA  1 
ATOM   2412 C C   . LYS C 1 17  ? -24.32400 -32.51500 -7.98300  1.000 35.42223 ? 17  LYS C C   1 
ATOM   2413 O O   . LYS C 1 17  ? -24.48100 -32.39200 -9.20800  1.000 27.28622 ? 17  LYS C O   1 
ATOM   2414 C CB  . LYS C 1 17  ? -24.16800 -30.59100 -6.39700  1.000 27.71055 ? 17  LYS C CB  1 
ATOM   2415 C CG  . LYS C 1 17  ? -24.88000 -29.38100 -5.78700  1.000 34.88793 ? 17  LYS C CG  1 
ATOM   2416 C CD  . LYS C 1 17  ? -23.90900 -28.23000 -5.47700  1.000 32.99122 ? 17  LYS C CD  1 
ATOM   2417 C CE  . LYS C 1 17  ? -24.36700 -27.46700 -4.24400  1.000 36.04628 ? 17  LYS C CE  1 
ATOM   2418 N NZ  . LYS C 1 17  ? -23.35900 -27.47500 -3.15200  1.000 36.96436 ? 17  LYS C NZ  1 
ATOM   2419 N N   . HIS C 1 18  ? -23.47300 -33.39500 -7.45200  1.000 32.48623 ? 18  HIS C N   1 
ATOM   2420 C CA  . HIS C 1 18  ? -22.82200 -34.40200 -8.27500  1.000 33.26362 ? 18  HIS C CA  1 
ATOM   2421 C C   . HIS C 1 18  ? -23.84000 -35.17700 -9.09800  1.000 34.29004 ? 18  HIS C C   1 
ATOM   2422 O O   . HIS C 1 18  ? -23.67700 -35.34400 -10.31100 1.000 34.71006 ? 18  HIS C O   1 
ATOM   2423 C CB  . HIS C 1 18  ? -22.00700 -35.34200 -7.38700  1.000 36.77822 ? 18  HIS C CB  1 
ATOM   2424 C CG  . HIS C 1 18  ? -20.99500 -36.14100 -8.14000  1.000 36.45173 ? 18  HIS C CG  1 
ATOM   2425 N ND1 . HIS C 1 18  ? -20.69600 -35.90300 -9.46500  1.000 42.41753 ? 18  HIS C ND1 1 
ATOM   2426 C CD2 . HIS C 1 18  ? -20.19300 -37.15900 -7.75500  1.000 42.89781 ? 18  HIS C CD2 1 
ATOM   2427 C CE1 . HIS C 1 18  ? -19.76900 -36.75100 -9.87200  1.000 39.05462 ? 18  HIS C CE1 1 
ATOM   2428 N NE2 . HIS C 1 18  ? -19.43500 -37.51600 -8.85100  1.000 49.92015 ? 18  HIS C NE2 1 
ATOM   2429 N N   . ALA C 1 19  ? -24.90900 -35.65300 -8.45300  1.000 35.05872 ? 19  ALA C N   1 
ATOM   2430 C CA  . ALA C 1 19  ? -25.91800 -36.41700 -9.17900  1.000 36.25157 ? 19  ALA C CA  1 
ATOM   2431 C C   . ALA C 1 19  ? -26.55400 -35.58100 -10.28300 1.000 36.07582 ? 19  ALA C C   1 
ATOM   2432 O O   . ALA C 1 19  ? -26.78700 -36.07200 -11.39400 1.000 36.13770 ? 19  ALA C O   1 
ATOM   2433 C CB  . ALA C 1 19  ? -26.99500 -36.93500 -8.22200  1.000 35.65804 ? 19  ALA C CB  1 
ATOM   2434 N N   . VAL C 1 20  ? -26.85800 -34.31200 -9.99800  1.000 32.47556 ? 20  VAL C N   1 
ATOM   2435 C CA  . VAL C 1 20  ? -27.47300 -33.49400 -11.03600 1.000 32.66405 ? 20  VAL C CA  1 
ATOM   2436 C C   . VAL C 1 20  ? -26.48900 -33.26100 -12.17700 1.000 30.32523 ? 20  VAL C C   1 
ATOM   2437 O O   . VAL C 1 20  ? -26.84400 -33.41900 -13.35200 1.000 29.54468 ? 20  VAL C O   1 
ATOM   2438 C CB  . VAL C 1 20  ? -28.03200 -32.18400 -10.44200 1.000 34.12401 ? 20  VAL C CB  1 
ATOM   2439 C CG1 . VAL C 1 20  ? -28.48000 -31.23100 -11.54900 1.000 29.63018 ? 20  VAL C CG1 1 
ATOM   2440 C CG2 . VAL C 1 20  ? -29.24300 -32.50200 -9.55500  1.000 28.91287 ? 20  VAL C CG2 1 
ATOM   2441 N N   . ALA C 1 21  ? -25.22400 -32.95200 -11.85300 1.000 29.81751 ? 21  ALA C N   1 
ATOM   2442 C CA  . ALA C 1 21  ? -24.22000 -32.74400 -12.89600 1.000 31.04357 ? 21  ALA C CA  1 
ATOM   2443 C C   . ALA C 1 21  ? -24.02600 -33.99200 -13.75800 1.000 33.59899 ? 21  ALA C C   1 
ATOM   2444 O O   . ALA C 1 21  ? -23.88300 -33.88400 -14.98600 1.000 33.91344 ? 21  ALA C O   1 
ATOM   2445 C CB  . ALA C 1 21  ? -22.89300 -32.31400 -12.28000 1.000 28.59975 ? 21  ALA C CB  1 
ATOM   2446 N N   . LYS C 1 22  ? -24.01900 -35.18500 -13.13900 1.000 33.41950 ? 22  LYS C N   1 
ATOM   2447 C CA  . LYS C 1 22  ? -23.80400 -36.41300 -13.91000 1.000 35.11332 ? 22  LYS C CA  1 
ATOM   2448 C C   . LYS C 1 22  ? -24.99300 -36.71500 -14.80900 1.000 31.60520 ? 22  LYS C C   1 
ATOM   2449 O O   . LYS C 1 22  ? -24.82300 -37.21900 -15.92700 1.000 36.07785 ? 22  LYS C O   1 
ATOM   2450 C CB  . LYS C 1 22  ? -23.50100 -37.61300 -12.99300 1.000 33.61248 ? 22  LYS C CB  1 
ATOM   2451 C CG  . LYS C 1 22  ? -24.58600 -38.06700 -12.00400 1.000 40.05336 ? 22  LYS C CG  1 
ATOM   2452 C CD  . LYS C 1 22  ? -25.59200 -39.07400 -12.60000 1.000 45.53446 ? 22  LYS C CD  1 
ATOM   2453 C CE  . LYS C 1 22  ? -26.95700 -39.02200 -11.88900 1.000 39.83537 ? 22  LYS C CE  1 
ATOM   2454 N NZ  . LYS C 1 22  ? -28.02900 -39.83700 -12.56700 1.000 48.70224 ? 22  LYS C NZ  1 
ATOM   2455 N N   . ALA C 1 23  ? -26.20200 -36.40300 -14.34100 1.000 32.96641 ? 23  ALA C N   1 
ATOM   2456 C CA  . ALA C 1 23  ? -27.38900 -36.57100 -15.17100 1.000 32.49337 ? 23  ALA C CA  1 
ATOM   2457 C C   . ALA C 1 23  ? -27.35000 -35.64600 -16.38600 1.000 31.00617 ? 23  ALA C C   1 
ATOM   2458 O O   . ALA C 1 23  ? -27.67900 -36.06200 -17.50600 1.000 30.10918 ? 23  ALA C O   1 
ATOM   2459 C CB  . ALA C 1 23  ? -28.64600 -36.31700 -14.33900 1.000 33.81896 ? 23  ALA C CB  1 
ATOM   2460 N N   . ILE C 1 24  ? -26.97500 -34.37800 -16.18200 1.000 29.19187 ? 24  ILE C N   1 
ATOM   2461 C CA  . ILE C 1 24  ? -26.96500 -33.43700 -17.29600 1.000 28.26973 ? 24  ILE C CA  1 
ATOM   2462 C C   . ILE C 1 24  ? -25.85600 -33.80900 -18.26100 1.000 32.30882 ? 24  ILE C C   1 
ATOM   2463 O O   . ILE C 1 24  ? -26.02900 -33.77400 -19.48400 1.000 32.04210 ? 24  ILE C O   1 
ATOM   2464 C CB  . ILE C 1 24  ? -26.80700 -31.99200 -16.79100 1.000 27.23242 ? 24  ILE C CB  1 
ATOM   2465 C CG1 . ILE C 1 24  ? -28.13400 -31.42900 -16.29700 1.000 30.04090 ? 24  ILE C CG1 1 
ATOM   2466 C CG2 . ILE C 1 24  ? -26.28600 -31.08600 -17.89300 1.000 26.44366 ? 24  ILE C CG2 1 
ATOM   2467 C CD1 . ILE C 1 24  ? -27.95000 -30.27500 -15.31400 1.000 30.80380 ? 24  ILE C CD1 1 
ATOM   2468 N N   . THR C 1 25  ? -24.71600 -34.22900 -17.71600 1.000 30.28970 ? 25  THR C N   1 
ATOM   2469 C CA  . THR C 1 25  ? -23.56100 -34.53900 -18.53700 1.000 29.61858 ? 25  THR C CA  1 
ATOM   2470 C C   . THR C 1 25  ? -23.77700 -35.81000 -19.33600 1.000 34.26960 ? 25  THR C C   1 
ATOM   2471 O O   . THR C 1 25  ? -23.48200 -35.84300 -20.53700 1.000 33.48638 ? 25  THR C O   1 
ATOM   2472 C CB  . THR C 1 25  ? -22.33700 -34.65300 -17.64700 1.000 32.62020 ? 25  THR C CB  1 
ATOM   2473 O OG1 . THR C 1 25  ? -22.16400 -33.40900 -16.94500 1.000 36.45743 ? 25  THR C OG1 1 
ATOM   2474 C CG2 . THR C 1 25  ? -21.11300 -34.92600 -18.46900 1.000 32.02197 ? 25  THR C CG2 1 
ATOM   2475 N N   . ASP C 1 26  ? -24.30000 -36.86100 -18.68800 1.000 32.19898 ? 26  ASP C N   1 
ATOM   2476 C CA  . ASP C 1 26  ? -24.55500 -38.11900 -19.39100 1.000 31.55211 ? 26  ASP C CA  1 
ATOM   2477 C C   . ASP C 1 26  ? -25.57000 -37.91400 -20.50000 1.000 30.47632 ? 26  ASP C C   1 
ATOM   2478 O O   . ASP C 1 26  ? -25.42200 -38.45600 -21.60300 1.000 36.58844 ? 26  ASP C O   1 
ATOM   2479 C CB  . ASP C 1 26  ? -25.06100 -39.19600 -18.42300 1.000 31.33535 ? 26  ASP C CB  1 
ATOM   2480 C CG  . ASP C 1 26  ? -23.95600 -39.77400 -17.53800 1.000 41.46972 ? 26  ASP C CG  1 
ATOM   2481 O OD1 . ASP C 1 26  ? -22.76900 -39.72200 -17.93200 1.000 42.40425 ? 26  ASP C OD1 1 
ATOM   2482 O OD2 . ASP C 1 26  ? -24.28000 -40.27300 -16.43300 1.000 39.29009 ? 26  ASP C OD2 1 
ATOM   2483 N N   . ALA C 1 27  ? -26.61600 -37.13900 -20.21900 1.000 32.11599 ? 27  ALA C N   1 
ATOM   2484 C CA  . ALA C 1 27  ? -27.62400 -36.84200 -21.23000 1.000 35.20979 ? 27  ALA C CA  1 
ATOM   2485 C C   . ALA C 1 27  ? -26.99700 -36.16300 -22.44900 1.000 34.68938 ? 27  ALA C C   1 
ATOM   2486 O O   . ALA C 1 27  ? -27.18600 -36.60300 -23.59200 1.000 29.49983 ? 27  ALA C O   1 
ATOM   2487 C CB  . ALA C 1 27  ? -28.71000 -35.96500 -20.61700 1.000 30.31905 ? 27  ALA C CB  1 
ATOM   2488 N N   . HIS C 1 28  ? -26.23000 -35.08900 -22.21700 1.000 35.25689 ? 28  HIS C N   1 
ATOM   2489 C CA  . HIS C 1 28  ? -25.60400 -34.36700 -23.31600 1.000 29.65738 ? 28  HIS C CA  1 
ATOM   2490 C C   . HIS C 1 28  ? -24.64300 -35.26400 -24.09600 1.000 34.76531 ? 28  HIS C C   1 
ATOM   2491 O O   . HIS C 1 28  ? -24.60200 -35.21900 -25.33200 1.000 30.22544 ? 28  HIS C O   1 
ATOM   2492 C CB  . HIS C 1 28  ? -24.88800 -33.13500 -22.77300 1.000 33.87720 ? 28  HIS C CB  1 
ATOM   2493 C CG  . HIS C 1 28  ? -24.47500 -32.16800 -23.83700 1.000 34.61872 ? 28  HIS C CG  1 
ATOM   2494 N ND1 . HIS C 1 28  ? -25.26300 -31.10200 -24.21500 1.000 31.73066 ? 28  HIS C ND1 1 
ATOM   2495 C CD2 . HIS C 1 28  ? -23.36100 -32.10800 -24.60500 1.000 31.97629 ? 28  HIS C CD2 1 
ATOM   2496 C CE1 . HIS C 1 28  ? -24.65500 -30.43200 -25.17800 1.000 33.00829 ? 28  HIS C CE1 1 
ATOM   2497 N NE2 . HIS C 1 28  ? -23.50100 -31.02200 -25.43200 1.000 31.67725 ? 28  HIS C NE2 1 
ATOM   2498 N N   . ARG C 1 29  ? -23.86300 -36.08500 -23.38200 1.000 32.32798 ? 29  ARG C N   1 
ATOM   2499 C CA  . ARG C 1 29  ? -22.96400 -37.04400 -24.01700 1.000 32.57373 ? 29  ARG C CA  1 
ATOM   2500 C C   . ARG C 1 29  ? -23.73500 -38.09300 -24.80300 1.000 33.02383 ? 29  ARG C C   1 
ATOM   2501 O O   . ARG C 1 29  ? -23.33700 -38.46800 -25.91300 1.000 29.20505 ? 29  ARG C O   1 
ATOM   2502 C CB  . ARG C 1 29  ? -22.11700 -37.74200 -22.95500 1.000 38.54700 ? 29  ARG C CB  1 
ATOM   2503 C CG  . ARG C 1 29  ? -20.78600 -38.20200 -23.45800 1.000 39.99864 ? 29  ARG C CG  1 
ATOM   2504 C CD  . ARG C 1 29  ? -20.76200 -39.65100 -23.96700 1.000 44.36576 ? 29  ARG C CD  1 
ATOM   2505 N NE  . ARG C 1 29  ? -19.38500 -40.12600 -24.03000 1.000 52.36374 ? 29  ARG C NE  1 
ATOM   2506 C CZ  . ARG C 1 29  ? -18.82100 -40.67000 -25.09700 1.000 52.70902 ? 29  ARG C CZ  1 
ATOM   2507 N NH1 . ARG C 1 29  ? -19.50400 -40.87100 -26.21000 1.000 53.11107 ? 29  ARG C NH1 1 
ATOM   2508 N NH2 . ARG C 1 29  ? -17.53800 -41.02400 -25.04300 1.000 55.22586 ? 29  ARG C NH2 1 
ATOM   2509 N N   . GLY C 1 30  ? -24.82500 -38.59500 -24.22300 1.000 32.06059 ? 30  GLY C N   1 
ATOM   2510 C CA  . GLY C 1 30  ? -25.56900 -39.66000 -24.86800 1.000 32.94932 ? 30  GLY C CA  1 
ATOM   2511 C C   . GLY C 1 30  ? -26.23500 -39.21200 -26.15500 1.000 33.42792 ? 30  GLY C C   1 
ATOM   2512 O O   . GLY C 1 30  ? -26.25400 -39.95100 -27.13500 1.000 34.96797 ? 30  GLY C O   1 
ATOM   2513 N N   . LEU C 1 31  ? -26.75900 -37.98100 -26.18700 1.000 32.10852 ? 31  LEU C N   1 
ATOM   2514 C CA  . LEU C 1 31  ? -27.56100 -37.56400 -27.33200 1.000 31.19067 ? 31  LEU C CA  1 
ATOM   2515 C C   . LEU C 1 31  ? -26.78100 -36.80100 -28.39200 1.000 34.25381 ? 31  LEU C C   1 
ATOM   2516 O O   . LEU C 1 31  ? -27.26600 -36.68600 -29.52200 1.000 41.22138 ? 31  LEU C O   1 
ATOM   2517 C CB  . LEU C 1 31  ? -28.74600 -36.72100 -26.87700 1.000 34.62373 ? 31  LEU C CB  1 
ATOM   2518 C CG  . LEU C 1 31  ? -29.95000 -37.59000 -26.49400 1.000 36.08857 ? 31  LEU C CG  1 
ATOM   2519 C CD1 . LEU C 1 31  ? -30.81900 -36.91500 -25.46100 1.000 28.52752 ? 31  LEU C CD1 1 
ATOM   2520 C CD2 . LEU C 1 31  ? -30.75200 -37.93300 -27.72100 1.000 32.15737 ? 31  LEU C CD2 1 
ATOM   2521 N N   . THR C 1 32  ? -25.58700 -36.29700 -28.08400 1.000 32.25497 ? 32  THR C N   1 
ATOM   2522 C CA  . THR C 1 32  ? -24.83600 -35.51800 -29.05700 1.000 31.85715 ? 32  THR C CA  1 
ATOM   2523 C C   . THR C 1 32  ? -23.50600 -36.12700 -29.47200 1.000 34.91907 ? 32  THR C C   1 
ATOM   2524 O O   . THR C 1 32  ? -22.95100 -35.70200 -30.49100 1.000 32.61501 ? 32  THR C O   1 
ATOM   2525 C CB  . THR C 1 32  ? -24.54500 -34.11600 -28.51300 1.000 33.65901 ? 32  THR C CB  1 
ATOM   2526 O OG1 . THR C 1 32  ? -23.52100 -34.22600 -27.52500 1.000 34.72350 ? 32  THR C OG1 1 
ATOM   2527 C CG2 . THR C 1 32  ? -25.78500 -33.49900 -27.88800 1.000 30.16855 ? 32  THR C CG2 1 
ATOM   2528 N N   . GLY C 1 33  ? -22.96300 -37.07000 -28.70900 1.000 32.43647 ? 33  GLY C N   1 
ATOM   2529 C CA  . GLY C 1 33  ? -21.64900 -37.59800 -28.98100 1.000 32.66836 ? 33  GLY C CA  1 
ATOM   2530 C C   . GLY C 1 33  ? -20.50700 -36.81400 -28.38300 1.000 33.20637 ? 33  GLY C C   1 
ATOM   2531 O O   . GLY C 1 33  ? -19.36500 -37.28200 -28.43600 1.000 37.67790 ? 33  GLY C O   1 
ATOM   2532 N N   . THR C 1 34  ? -20.76600 -35.64200 -27.81300 1.000 36.89201 ? 34  THR C N   1 
ATOM   2533 C CA  . THR C 1 34  ? -19.70100 -34.82800 -27.23200 1.000 36.95199 ? 34  THR C CA  1 
ATOM   2534 C C   . THR C 1 34  ? -19.08500 -35.53000 -26.03900 1.000 38.31802 ? 34  THR C C   1 
ATOM   2535 O O   . THR C 1 34  ? -19.80200 -36.05500 -25.19700 1.000 36.60526 ? 34  THR C O   1 
ATOM   2536 C CB  . THR C 1 34  ? -20.25600 -33.47700 -26.79500 1.000 32.61283 ? 34  THR C CB  1 
ATOM   2537 O OG1 . THR C 1 34  ? -20.76700 -32.78700 -27.94500 1.000 37.91463 ? 34  THR C OG1 1 
ATOM   2538 C CG2 . THR C 1 34  ? -19.17500 -32.64300 -26.13500 1.000 37.28540 ? 34  THR C CG2 1 
ATOM   2539 N N   . GLN C 1 35  ? -17.75300 -35.55300 -25.97000 1.000 43.22191 ? 35  GLN C N   1 
ATOM   2540 C CA  . GLN C 1 35  ? -17.08600 -36.23700 -24.86400 1.000 40.14579 ? 35  GLN C CA  1 
ATOM   2541 C C   . GLN C 1 35  ? -17.42900 -35.57100 -23.53600 1.000 41.44249 ? 35  GLN C C   1 
ATOM   2542 O O   . GLN C 1 35  ? -17.63700 -34.35200 -23.45200 1.000 38.31906 ? 35  GLN C O   1 
ATOM   2543 C CB  . GLN C 1 35  ? -15.56700 -36.24200 -25.04400 1.000 38.22719 ? 35  GLN C CB  1 
ATOM   2544 C CG  . GLN C 1 35  ? -15.07800 -36.87800 -26.32600 1.000 39.43638 ? 35  GLN C CG  1 
ATOM   2545 C CD  . GLN C 1 35  ? -14.67700 -35.82400 -27.32000 1.000 43.14831 ? 35  GLN C CD  1 
ATOM   2546 O OE1 . GLN C 1 35  ? -15.40300 -34.84700 -27.51300 1.000 40.51346 ? 35  GLN C OE1 1 
ATOM   2547 N NE2 . GLN C 1 35  ? -13.49700 -35.98100 -27.92000 1.000 45.34205 ? 35  GLN C NE2 1 
ATOM   2548 N N   . HIS C 1 36  ? -17.49500 -36.39900 -22.49600 1.000 34.84226 ? 36  HIS C N   1 
ATOM   2549 C CA  . HIS C 1 36  ? -17.82700 -35.93400 -21.15700 1.000 36.99863 ? 36  HIS C CA  1 
ATOM   2550 C C   . HIS C 1 36  ? -17.10600 -34.64500 -20.78700 1.000 37.70532 ? 36  HIS C C   1 
ATOM   2551 O O   . HIS C 1 36  ? -17.73600 -33.67800 -20.34700 1.000 39.15313 ? 36  HIS C O   1 
ATOM   2552 C CB  . HIS C 1 36  ? -17.48800 -37.04000 -20.15300 1.000 38.38812 ? 36  HIS C CB  1 
ATOM   2553 C CG  . HIS C 1 36  ? -18.61700 -37.98800 -19.91000 1.000 37.63501 ? 36  HIS C CG  1 
ATOM   2554 N ND1 . HIS C 1 36  ? -18.67000 -39.24100 -20.48000 1.000 47.95281 ? 36  HIS C ND1 1 
ATOM   2555 C CD2 . HIS C 1 36  ? -19.71700 -37.88400 -19.12800 1.000 41.87991 ? 36  HIS C CD2 1 
ATOM   2556 C CE1 . HIS C 1 36  ? -19.76900 -39.85900 -20.08100 1.000 45.92651 ? 36  HIS C CE1 1 
ATOM   2557 N NE2 . HIS C 1 36  ? -20.42100 -39.05700 -19.25900 1.000 48.30823 ? 36  HIS C NE2 1 
ATOM   2558 N N   . PHE C 1 37  ? -15.78200 -34.60100 -20.97900 1.000 38.77118 ? 37  PHE C N   1 
ATOM   2559 C CA  . PHE C 1 37  ? -14.98700 -33.50400 -20.43200 1.000 36.00934 ? 37  PHE C CA  1 
ATOM   2560 C C   . PHE C 1 37  ? -15.25800 -32.16000 -21.10900 1.000 35.98203 ? 37  PHE C C   1 
ATOM   2561 O O   . PHE C 1 37  ? -14.84200 -31.12500 -20.57700 1.000 31.57001 ? 37  PHE C O   1 
ATOM   2562 C CB  . PHE C 1 37  ? -13.49700 -33.86000 -20.49400 1.000 36.62169 ? 37  PHE C CB  1 
ATOM   2563 C CG  . PHE C 1 37  ? -13.01800 -34.31200 -21.85700 1.000 36.27847 ? 37  PHE C CG  1 
ATOM   2564 C CD1 . PHE C 1 37  ? -12.87900 -33.40800 -22.90500 1.000 40.71475 ? 37  PHE C CD1 1 
ATOM   2565 C CD2 . PHE C 1 37  ? -12.68800 -35.63400 -22.07700 1.000 35.95140 ? 37  PHE C CD2 1 
ATOM   2566 C CE1 . PHE C 1 37  ? -12.42600 -33.81700 -24.15000 1.000 36.45430 ? 37  PHE C CE1 1 
ATOM   2567 C CE2 . PHE C 1 37  ? -12.23900 -36.05000 -23.31400 1.000 41.38889 ? 37  PHE C CE2 1 
ATOM   2568 C CZ  . PHE C 1 37  ? -12.11000 -35.13900 -24.35400 1.000 41.98430 ? 37  PHE C CZ  1 
ATOM   2569 N N   . LEU C 1 38  ? -15.94800 -32.13000 -22.24500 1.000 33.31572 ? 38  LEU C N   1 
ATOM   2570 C CA  . LEU C 1 38  ? -16.31500 -30.85400 -22.84500 1.000 31.93347 ? 38  LEU C CA  1 
ATOM   2571 C C   . LEU C 1 38  ? -17.60700 -30.27500 -22.26500 1.000 35.54062 ? 38  LEU C C   1 
ATOM   2572 O O   . LEU C 1 38  ? -18.00800 -29.17700 -22.67100 1.000 28.89181 ? 38  LEU C O   1 
ATOM   2573 C CB  . LEU C 1 38  ? -16.43500 -31.00500 -24.36400 1.000 33.15008 ? 38  LEU C CB  1 
ATOM   2574 C CG  . LEU C 1 38  ? -15.10900 -31.25300 -25.10600 1.000 35.04295 ? 38  LEU C CG  1 
ATOM   2575 C CD1 . LEU C 1 38  ? -15.31400 -31.29600 -26.62100 1.000 38.32199 ? 38  LEU C CD1 1 
ATOM   2576 C CD2 . LEU C 1 38  ? -14.08600 -30.19200 -24.74700 1.000 31.34235 ? 38  LEU C CD2 1 
ATOM   2577 N N   . ALA C 1 39  ? -18.25900 -30.96800 -21.31500 1.000 30.89732 ? 39  ALA C N   1 
ATOM   2578 C CA  . ALA C 1 39  ? -19.52000 -30.51600 -20.73000 1.000 26.98420 ? 39  ALA C CA  1 
ATOM   2579 C C   . ALA C 1 39  ? -19.28800 -30.02300 -19.30600 1.000 30.64159 ? 39  ALA C C   1 
ATOM   2580 O O   . ALA C 1 39  ? -18.89400 -30.80300 -18.43000 1.000 27.07665 ? 39  ALA C O   1 
ATOM   2581 C CB  . ALA C 1 39  ? -20.56500 -31.62700 -20.74700 1.000 33.18543 ? 39  ALA C CB  1 
ATOM   2582 N N   . GLN C 1 40  ? -19.52600 -28.73000 -19.09200 1.000 28.52289 ? 40  GLN C N   1 
ATOM   2583 C CA  . GLN C 1 40  ? -19.42300 -28.08800 -17.78900 1.000 30.84379 ? 40  GLN C CA  1 
ATOM   2584 C C   . GLN C 1 40  ? -20.81800 -27.84400 -17.24400 1.000 30.94238 ? 40  GLN C C   1 
ATOM   2585 O O   . GLN C 1 40  ? -21.73000 -27.46400 -17.98800 1.000 26.05629 ? 40  GLN C O   1 
ATOM   2586 C CB  . GLN C 1 40  ? -18.68200 -26.75000 -17.86900 1.000 26.47294 ? 40  GLN C CB  1 
ATOM   2587 C CG  . GLN C 1 40  ? -18.78600 -25.92900 -16.59400 1.000 24.75815 ? 40  GLN C CG  1 
ATOM   2588 C CD  . GLN C 1 40  ? -18.04100 -24.59900 -16.65000 1.000 25.76936 ? 40  GLN C CD  1 
ATOM   2589 O OE1 . GLN C 1 40  ? -18.35000 -23.68500 -15.88700 1.000 30.11731 ? 40  GLN C OE1 1 
ATOM   2590 N NE2 . GLN C 1 40  ? -17.05700 -24.48900 -17.53900 1.000 25.59348 ? 40  GLN C NE2 1 
ATOM   2591 N N   . VAL C 1 41  ? -20.97800 -28.08500 -15.94700 1.000 24.33377 ? 41  VAL C N   1 
ATOM   2592 C CA  . VAL C 1 41  ? -22.20500 -27.79500 -15.21500 1.000 26.93979 ? 41  VAL C CA  1 
ATOM   2593 C C   . VAL C 1 41  ? -21.79300 -26.89600 -14.05700 1.000 27.17546 ? 41  VAL C C   1 
ATOM   2594 O O   . VAL C 1 41  ? -20.90600 -27.25700 -13.27500 1.000 26.93572 ? 41  VAL C O   1 
ATOM   2595 C CB  . VAL C 1 41  ? -22.91100 -29.07600 -14.71500 1.000 29.77943 ? 41  VAL C CB  1 
ATOM   2596 C CG1 . VAL C 1 41  ? -24.18800 -28.74800 -13.93200 1.000 21.07321 ? 41  VAL C CG1 1 
ATOM   2597 C CG2 . VAL C 1 41  ? -23.23000 -30.00600 -15.87300 1.000 26.25264 ? 41  VAL C CG2 1 
ATOM   2598 N N   . ASN C 1 42  ? -22.39700 -25.71300 -13.97200 1.000 26.23091 ? 42  ASN C N   1 
ATOM   2599 C CA  . ASN C 1 42  ? -21.93600 -24.66000 -13.07200 1.000 26.67095 ? 42  ASN C CA  1 
ATOM   2600 C C   . ASN C 1 42  ? -23.12400 -24.23600 -12.20100 1.000 29.39532 ? 42  ASN C C   1 
ATOM   2601 O O   . ASN C 1 42  ? -24.04400 -23.54200 -12.65700 1.000 26.43964 ? 42  ASN C O   1 
ATOM   2602 C CB  . ASN C 1 42  ? -21.34100 -23.51700 -13.89800 1.000 23.63909 ? 42  ASN C CB  1 
ATOM   2603 C CG  . ASN C 1 42  ? -20.60500 -22.49300 -13.05900 1.000 27.66568 ? 42  ASN C CG  1 
ATOM   2604 O OD1 . ASN C 1 42  ? -20.93500 -22.27200 -11.90500 1.000 34.54597 ? 42  ASN C OD1 1 
ATOM   2605 N ND2 . ASN C 1 42  ? -19.59000 -21.86000 -13.65000 1.000 31.11209 ? 42  ASN C ND2 1 
ATOM   2606 N N   . PHE C 1 43  ? -23.14700 -24.70600 -10.95600 1.000 27.04127 ? 43  PHE C N   1 
ATOM   2607 C CA  . PHE C 1 43  ? -24.27400 -24.42500 -10.06800 1.000 27.85002 ? 43  PHE C CA  1 
ATOM   2608 C C   . PHE C 1 43  ? -24.16300 -23.00700 -9.53700  1.000 30.36644 ? 43  PHE C C   1 
ATOM   2609 O O   . PHE C 1 43  ? -23.09700 -22.59000 -9.07100  1.000 30.81307 ? 43  PHE C O   1 
ATOM   2610 C CB  . PHE C 1 43  ? -24.30900 -25.41200 -8.90400  1.000 28.54125 ? 43  PHE C CB  1 
ATOM   2611 C CG  . PHE C 1 43  ? -24.69500 -26.78800 -9.31000  1.000 30.18039 ? 43  PHE C CG  1 
ATOM   2612 C CD1 . PHE C 1 43  ? -26.03000 -27.14600 -9.40500  1.000 27.89429 ? 43  PHE C CD1 1 
ATOM   2613 C CD2 . PHE C 1 43  ? -23.72800 -27.72100 -9.63600  1.000 27.99941 ? 43  PHE C CD2 1 
ATOM   2614 C CE1 . PHE C 1 43  ? -26.38600 -28.40600 -9.79400  1.000 25.86565 ? 43  PHE C CE1 1 
ATOM   2615 C CE2 . PHE C 1 43  ? -24.08800 -28.98600 -10.03500 1.000 26.30094 ? 43  PHE C CE2 1 
ATOM   2616 C CZ  . PHE C 1 43  ? -25.41600 -29.32500 -10.11500 1.000 27.21096 ? 43  PHE C CZ  1 
ATOM   2617 N N   . GLN C 1 44  ? -25.26000 -22.27300 -9.61500  1.000 28.17033 ? 44  GLN C N   1 
ATOM   2618 C CA  . GLN C 1 44  ? -25.34700 -20.90700 -9.11700  1.000 27.38801 ? 44  GLN C CA  1 
ATOM   2619 C C   . GLN C 1 44  ? -26.38400 -20.88700 -8.00800  1.000 27.66770 ? 44  GLN C C   1 
ATOM   2620 O O   . GLN C 1 44  ? -27.58800 -20.96600 -8.27600  1.000 27.58475 ? 44  GLN C O   1 
ATOM   2621 C CB  . GLN C 1 44  ? -25.71300 -19.94400 -10.24200 1.000 25.66514 ? 44  GLN C CB  1 
ATOM   2622 C CG  . GLN C 1 44  ? -24.70200 -19.97700 -11.38700 1.000 25.27765 ? 44  GLN C CG  1 
ATOM   2623 C CD  . GLN C 1 44  ? -23.41400 -19.26700 -11.01600 1.000 29.29423 ? 44  GLN C CD  1 
ATOM   2624 O OE1 . GLN C 1 44  ? -23.41900 -18.07800 -10.71500 1.000 29.81468 ? 44  GLN C OE1 1 
ATOM   2625 N NE2 . GLN C 1 44  ? -22.30600 -19.99300 -11.03000 1.000 26.87192 ? 44  GLN C NE2 1 
ATOM   2626 N N   . GLU C 1 45  ? -25.92100 -20.76900 -6.76800  1.000 28.64776 ? 45  GLU C N   1 
ATOM   2627 C CA  . GLU C 1 45  ? -26.78600 -20.82200 -5.59800  1.000 29.14246 ? 45  GLU C CA  1 
ATOM   2628 C C   . GLU C 1 45  ? -27.12700 -19.41600 -5.13600  1.000 28.41130 ? 45  GLU C C   1 
ATOM   2629 O O   . GLU C 1 45  ? -26.25300 -18.54200 -5.08500  1.000 30.23868 ? 45  GLU C O   1 
ATOM   2630 C CB  . GLU C 1 45  ? -26.11900 -21.61200 -4.46900  1.000 28.05038 ? 45  GLU C CB  1 
ATOM   2631 C CG  . GLU C 1 45  ? -26.02900 -23.10500 -4.79500  1.000 32.67919 ? 45  GLU C CG  1 
ATOM   2632 C CD  . GLU C 1 45  ? -25.21400 -23.88700 -3.78800  1.000 31.83478 ? 45  GLU C CD  1 
ATOM   2633 O OE1 . GLU C 1 45  ? -24.00900 -23.61400 -3.64000  1.000 39.12609 ? 45  GLU C OE1 1 
ATOM   2634 O OE2 . GLU C 1 45  ? -25.77500 -24.79900 -3.16000  1.000 38.27502 ? 45  GLU C OE2 1 
ATOM   2635 N N   . GLN C 1 46  ? -28.39300 -19.20900 -4.79300  1.000 30.18723 ? 46  GLN C N   1 
ATOM   2636 C CA  . GLN C 1 46  ? -28.89700 -17.96000 -4.24500  1.000 29.88454 ? 46  GLN C CA  1 
ATOM   2637 C C   . GLN C 1 46  ? -29.84500 -18.31200 -3.11100  1.000 30.02020 ? 46  GLN C C   1 
ATOM   2638 O O   . GLN C 1 46  ? -30.48300 -19.37100 -3.15400  1.000 26.29492 ? 46  GLN C O   1 
ATOM   2639 C CB  . GLN C 1 46  ? -29.64600 -17.13500 -5.30500  1.000 21.59033 ? 46  GLN C CB  1 
ATOM   2640 C CG  . GLN C 1 46  ? -28.77400 -16.47100 -6.34200  1.000 25.48262 ? 46  GLN C CG  1 
ATOM   2641 C CD  . GLN C 1 46  ? -27.98800 -15.32000 -5.76500  1.000 25.64208 ? 46  GLN C CD  1 
ATOM   2642 O OE1 . GLN C 1 46  ? -28.55100 -14.46100 -5.08700  1.000 28.45991 ? 46  GLN C OE1 1 
ATOM   2643 N NE2 . GLN C 1 46  ? -26.69000 -15.26300 -6.07000  1.000 27.70009 ? 46  GLN C NE2 1 
ATOM   2644 N N   . PRO C 1 47  ? -29.96300 -17.45400 -2.09400  1.000 28.44151 ? 47  PRO C N   1 
ATOM   2645 C CA  . PRO C 1 47  ? -30.91000 -17.73000 -1.00200  1.000 30.54210 ? 47  PRO C CA  1 
ATOM   2646 C C   . PRO C 1 47  ? -32.30800 -18.03100 -1.53400  1.000 28.43173 ? 47  PRO C C   1 
ATOM   2647 O O   . PRO C 1 47  ? -32.73400 -17.48300 -2.55300  1.000 27.05910 ? 47  PRO C O   1 
ATOM   2648 C CB  . PRO C 1 47  ? -30.89900 -16.43900 -0.16800  1.000 28.83421 ? 47  PRO C CB  1 
ATOM   2649 C CG  . PRO C 1 47  ? -29.95700 -15.49500 -0.80900  1.000 32.79171 ? 47  PRO C CG  1 
ATOM   2650 C CD  . PRO C 1 47  ? -29.25400 -16.16800 -1.95200  1.000 26.79105 ? 47  PRO C CD  1 
ATOM   2651 N N   . ALA C 1 48  ? -33.02100 -18.91200 -0.83200  1.000 26.72309 ? 48  ALA C N   1 
ATOM   2652 C CA  . ALA C 1 48  ? -34.41800 -19.16300 -1.15200  1.000 29.08650 ? 48  ALA C CA  1 
ATOM   2653 C C   . ALA C 1 48  ? -35.23200 -17.89200 -0.94900  1.000 26.76906 ? 48  ALA C C   1 
ATOM   2654 O O   . ALA C 1 48  ? -34.96100 -17.09900 -0.04800  1.000 29.98660 ? 48  ALA C O   1 
ATOM   2655 C CB  . ALA C 1 48  ? -34.97200 -20.29700 -0.29000  1.000 30.99993 ? 48  ALA C CB  1 
ATOM   2656 N N   . GLY C 1 49  ? -36.22600 -17.69200 -1.81200  1.000 31.75379 ? 49  GLY C N   1 
ATOM   2657 C CA  . GLY C 1 49  ? -36.95000 -16.44500 -1.87200  1.000 26.05550 ? 49  GLY C CA  1 
ATOM   2658 C C   . GLY C 1 49  ? -36.43500 -15.49000 -2.92700  1.000 32.08359 ? 49  GLY C C   1 
ATOM   2659 O O   . GLY C 1 49  ? -37.02700 -14.41500 -3.10600  1.000 28.91540 ? 49  GLY C O   1 
ATOM   2660 N N   . ASN C 1 50  ? -35.35000 -15.84500 -3.63000  1.000 29.02919 ? 50  ASN C N   1 
ATOM   2661 C CA  . ASN C 1 50  ? -34.86000 -15.00800 -4.71100  1.000 24.47892 ? 50  ASN C CA  1 
ATOM   2662 C C   . ASN C 1 50  ? -35.54000 -15.30000 -6.05300  1.000 27.82046 ? 50  ASN C C   1 
ATOM   2663 O O   . ASN C 1 50  ? -35.38700 -14.49500 -6.98100  1.000 29.56859 ? 50  ASN C O   1 
ATOM   2664 C CB  . ASN C 1 50  ? -33.32600 -15.12600 -4.83400  1.000 23.81461 ? 50  ASN C CB  1 
ATOM   2665 C CG  . ASN C 1 50  ? -32.56600 -14.08000 -3.95000  1.000 30.53076 ? 50  ASN C CG  1 
ATOM   2666 O OD1 . ASN C 1 50  ? -33.17700 -13.32800 -3.18900  1.000 28.36912 ? 50  ASN C OD1 1 
ATOM   2667 N ND2 . ASN C 1 50  ? -31.24000 -14.01000 -4.10700  1.000 27.14101 ? 50  ASN C ND2 1 
ATOM   2668 N N   . VAL C 1 51  ? -36.31900 -16.38400 -6.16900  1.000 26.33159 ? 51  VAL C N   1 
ATOM   2669 C CA  . VAL C 1 51  ? -37.08800 -16.70100 -7.37800  1.000 21.36139 ? 51  VAL C CA  1 
ATOM   2670 C C   . VAL C 1 51  ? -38.51900 -16.21400 -7.21800  1.000 25.93566 ? 51  VAL C C   1 
ATOM   2671 O O   . VAL C 1 51  ? -39.17500 -16.49400 -6.20600  1.000 29.47484 ? 51  VAL C O   1 
ATOM   2672 C CB  . VAL C 1 51  ? -37.06900 -18.20900 -7.67100  1.000 22.44853 ? 51  VAL C CB  1 
ATOM   2673 C CG1 . VAL C 1 51  ? -37.90900 -18.52300 -8.89100  1.000 24.03906 ? 51  VAL C CG1 1 
ATOM   2674 C CG2 . VAL C 1 51  ? -35.65600 -18.67300 -7.89200  1.000 28.54717 ? 51  VAL C CG2 1 
ATOM   2675 N N   . PHE C 1 52  ? -39.01900 -15.51100 -8.22300  1.000 24.20860 ? 52  PHE C N   1 
ATOM   2676 C CA  . PHE C 1 52  ? -40.40600 -15.08800 -8.25400  1.000 23.68857 ? 52  PHE C CA  1 
ATOM   2677 C C   . PHE C 1 52  ? -41.06400 -15.65600 -9.50500  1.000 27.65594 ? 52  PHE C C   1 
ATOM   2678 O O   . PHE C 1 52  ? -40.48200 -15.60300 -10.59800 1.000 26.00163 ? 52  PHE C O   1 
ATOM   2679 C CB  . PHE C 1 52  ? -40.50700 -13.55800 -8.24000  1.000 26.02175 ? 52  PHE C CB  1 
ATOM   2680 C CG  . PHE C 1 52  ? -40.19300 -12.93800 -6.89900  1.000 24.79312 ? 52  PHE C CG  1 
ATOM   2681 C CD1 . PHE C 1 52  ? -38.88200 -12.83600 -6.45900  1.000 24.10235 ? 52  PHE C CD1 1 
ATOM   2682 C CD2 . PHE C 1 52  ? -41.21400 -12.46300 -6.07900  1.000 25.87470 ? 52  PHE C CD2 1 
ATOM   2683 C CE1 . PHE C 1 52  ? -38.58000 -12.27900 -5.21800  1.000 29.83572 ? 52  PHE C CE1 1 
ATOM   2684 C CE2 . PHE C 1 52  ? -40.92900 -11.90400 -4.85000  1.000 30.15097 ? 52  PHE C CE2 1 
ATOM   2685 C CZ  . PHE C 1 52  ? -39.60500 -11.80300 -4.41900  1.000 28.29278 ? 52  PHE C CZ  1 
ATOM   2686 N N   . LEU C 1 53  ? -42.27200 -16.20500 -9.34900  1.000 25.50625 ? 53  LEU C N   1 
ATOM   2687 C CA  . LEU C 1 53  ? -43.07300 -16.70700 -10.46500 1.000 29.02177 ? 53  LEU C CA  1 
ATOM   2688 C C   . LEU C 1 53  ? -44.39500 -15.95500 -10.49500 1.000 31.56563 ? 53  LEU C C   1 
ATOM   2689 O O   . LEU C 1 53  ? -45.17900 -16.03800 -9.53800  1.000 28.61435 ? 53  LEU C O   1 
ATOM   2690 C CB  . LEU C 1 53  ? -43.33300 -18.21000 -10.35100 1.000 30.61153 ? 53  LEU C CB  1 
ATOM   2691 C CG  . LEU C 1 53  ? -42.08500 -19.08400 -10.29100 1.000 32.05796 ? 53  LEU C CG  1 
ATOM   2692 C CD1 . LEU C 1 53  ? -42.48300 -20.52400 -10.42500 1.000 30.96751 ? 53  LEU C CD1 1 
ATOM   2693 C CD2 . LEU C 1 53  ? -41.07500 -18.70500 -11.34100 1.000 26.98947 ? 53  LEU C CD2 1 
ATOM   2694 N N   . GLY C 1 54  ? -44.64500 -15.23800 -11.59400 1.000 27.69559 ? 54  GLY C N   1 
ATOM   2695 C CA  . GLY C 1 54  ? -45.85800 -14.44500 -11.67800 1.000 31.51776 ? 54  GLY C CA  1 
ATOM   2696 C C   . GLY C 1 54  ? -46.01800 -13.42000 -10.57500 1.000 31.35841 ? 54  GLY C C   1 
ATOM   2697 O O   . GLY C 1 54  ? -47.13200 -12.96500 -10.31900 1.000 31.07513 ? 54  GLY C O   1 
ATOM   2698 N N   . GLY C 1 55  ? -44.92700 -13.03800 -9.91400  1.000 30.12125 ? 55  GLY C N   1 
ATOM   2699 C CA  . GLY C 1 55  ? -44.97800 -12.09600 -8.82600  1.000 33.30472 ? 55  GLY C CA  1 
ATOM   2700 C C   . GLY C 1 55  ? -44.99400 -12.73100 -7.45600  1.000 34.10323 ? 55  GLY C C   1 
ATOM   2701 O O   . GLY C 1 55  ? -44.86300 -12.01400 -6.46000  1.000 29.79766 ? 55  GLY C O   1 
ATOM   2702 N N   . VAL C 1 56  ? -45.14000 -14.05300 -7.38500  1.000 33.64188 ? 56  VAL C N   1 
ATOM   2703 C CA  . VAL C 1 56  ? -45.21600 -14.78200 -6.12400  1.000 30.47185 ? 56  VAL C CA  1 
ATOM   2704 C C   . VAL C 1 56  ? -43.82300 -15.25900 -5.74000  1.000 33.97207 ? 56  VAL C C   1 
ATOM   2705 O O   . VAL C 1 56  ? -43.16400 -15.96000 -6.51600  1.000 31.43764 ? 56  VAL C O   1 
ATOM   2706 C CB  . VAL C 1 56  ? -46.17900 -15.97000 -6.24000  1.000 34.41819 ? 56  VAL C CB  1 
ATOM   2707 C CG1 . VAL C 1 56  ? -46.23500 -16.73500 -4.91700  1.000 31.00175 ? 56  VAL C CG1 1 
ATOM   2708 C CG2 . VAL C 1 56  ? -47.56100 -15.49100 -6.70200  1.000 32.86893 ? 56  VAL C CG2 1 
ATOM   2709 N N   . GLN C 1 57  ? -43.38400 -14.90400 -4.53700  1.000 24.39562 ? 57  GLN C N   1 
ATOM   2710 C CA  . GLN C 1 57  ? -42.09300 -15.36500 -4.05400  1.000 26.94389 ? 57  GLN C CA  1 
ATOM   2711 C C   . GLN C 1 57  ? -42.13100 -16.86700 -3.85200  1.000 28.29254 ? 57  GLN C C   1 
ATOM   2712 O O   . GLN C 1 57  ? -43.10200 -17.39900 -3.31300  1.000 29.32374 ? 57  GLN C O   1 
ATOM   2713 C CB  . GLN C 1 57  ? -41.73500 -14.67100 -2.74500  1.000 27.18209 ? 57  GLN C CB  1 
ATOM   2714 C CG  . GLN C 1 57  ? -40.37300 -15.05000 -2.22600  1.000 31.48983 ? 57  GLN C CG  1 
ATOM   2715 C CD  . GLN C 1 57  ? -39.98300 -14.25300 -0.98900  1.000 34.27850 ? 57  GLN C CD  1 
ATOM   2716 O OE1 . GLN C 1 57  ? -40.80100 -14.03200 -0.09200  1.000 29.55317 ? 57  GLN C OE1 1 
ATOM   2717 N NE2 . GLN C 1 57  ? -38.73600 -13.81300 -0.94400  1.000 32.99217 ? 57  GLN C NE2 1 
ATOM   2718 N N   . GLN C 1 58  ? -41.08900 -17.55400 -4.30300  1.000 27.34105 ? 58  GLN C N   1 
ATOM   2719 C CA  . GLN C 1 58  ? -41.04400 -19.00200 -4.24500  1.000 32.29356 ? 58  GLN C CA  1 
ATOM   2720 C C   . GLN C 1 58  ? -40.24100 -19.45200 -3.03600  1.000 33.64375 ? 58  GLN C C   1 
ATOM   2721 O O   . GLN C 1 58  ? -39.42000 -18.70800 -2.49300  1.000 30.82155 ? 58  GLN C O   1 
ATOM   2722 C CB  . GLN C 1 58  ? -40.42700 -19.59800 -5.51600  1.000 32.20320 ? 58  GLN C CB  1 
ATOM   2723 C CG  . GLN C 1 58  ? -41.21200 -19.31800 -6.78800  1.000 30.29784 ? 58  GLN C CG  1 
ATOM   2724 C CD  . GLN C 1 58  ? -42.58400 -19.92900 -6.74700  1.000 31.23281 ? 58  GLN C CD  1 
ATOM   2725 O OE1 . GLN C 1 58  ? -42.73300 -21.15500 -6.79100  1.000 36.51018 ? 58  GLN C OE1 1 
ATOM   2726 N NE2 . GLN C 1 58  ? -43.60200 -19.08300 -6.66500  1.000 30.58358 ? 58  GLN C NE2 1 
ATOM   2727 N N   . GLY C 1 59  ? -40.48900 -20.69700 -2.62900  1.000 34.18971 ? 59  GLY C N   1 
ATOM   2728 C CA  . GLY C 1 59  ? -39.59900 -21.40800 -1.72600  1.000 38.33225 ? 59  GLY C CA  1 
ATOM   2729 C C   . GLY C 1 59  ? -38.29100 -21.71500 -2.43500  1.000 42.53799 ? 59  GLY C C   1 
ATOM   2730 O O   . GLY C 1 59  ? -37.75000 -20.86400 -3.14600  1.000 49.17418 ? 59  GLY C O   1 
ATOM   2731 N N   . GLY C 1 60  ? -37.76600 -22.91500 -2.28300  1.000 37.94164 ? 60  GLY C N   1 
ATOM   2732 C CA  . GLY C 1 60  ? -36.45700 -23.14000 -2.85700  1.000 35.40321 ? 60  GLY C CA  1 
ATOM   2733 C C   . GLY C 1 60  ? -36.38300 -24.32900 -3.78500  1.000 32.36569 ? 60  GLY C C   1 
ATOM   2734 O O   . GLY C 1 60  ? -35.29600 -24.86100 -4.01800  1.000 34.81497 ? 60  GLY C O   1 
ATOM   2735 N N   . ASP C 1 61  ? -37.52300 -24.76300 -4.31600  1.000 31.61536 ? 61  ASP C N   1 
ATOM   2736 C CA  . ASP C 1 61  ? -37.53400 -25.96600 -5.13800  1.000 34.75004 ? 61  ASP C CA  1 
ATOM   2737 C C   . ASP C 1 61  ? -37.30200 -25.70600 -6.62100  1.000 33.26491 ? 61  ASP C C   1 
ATOM   2738 O O   . ASP C 1 61  ? -37.04200 -26.66500 -7.35100  1.000 39.56338 ? 61  ASP C O   1 
ATOM   2739 C CB  . ASP C 1 61  ? -38.86000 -26.73400 -4.99500  1.000 37.99178 ? 61  ASP C CB  1 
ATOM   2740 C CG  . ASP C 1 61  ? -39.05700 -27.34300 -3.60700  1.000 42.51249 ? 61  ASP C CG  1 
ATOM   2741 O OD1 . ASP C 1 61  ? -38.05700 -27.53400 -2.87700  1.000 40.17179 ? 61  ASP C OD1 1 
ATOM   2742 O OD2 . ASP C 1 61  ? -40.21100 -27.67200 -3.26100  1.000 43.37943 ? 61  ASP C OD2 1 
ATOM   2743 N N   . THR C 1 62  ? -37.41800 -24.46600 -7.10200  1.000 32.04289 ? 62  THR C N   1 
ATOM   2744 C CA  . THR C 1 62  ? -37.29800 -24.23300 -8.53600  1.000 32.04130 ? 62  THR C CA  1 
ATOM   2745 C C   . THR C 1 62  ? -35.86500 -24.50100 -8.98800  1.000 31.19467 ? 62  THR C C   1 
ATOM   2746 O O   . THR C 1 62  ? -34.90300 -24.18400 -8.28300  1.000 26.96833 ? 62  THR C O   1 
ATOM   2747 C CB  . THR C 1 62  ? -37.70200 -22.80000 -8.91400  1.000 32.78429 ? 62  THR C CB  1 
ATOM   2748 O OG1 . THR C 1 62  ? -38.86400 -22.39300 -8.18500  1.000 31.37349 ? 62  THR C OG1 1 
ATOM   2749 C CG2 . THR C 1 62  ? -38.03100 -22.72100 -10.41300 1.000 30.74594 ? 62  THR C CG2 1 
ATOM   2750 N N   . ILE C 1 63  ? -35.73800 -25.11900 -10.16000 1.000 27.97708 ? 63  ILE C N   1 
ATOM   2751 C CA  . ILE C 1 63  ? -34.46400 -25.37200 -10.82000 1.000 27.18408 ? 63  ILE C CA  1 
ATOM   2752 C C   . ILE C 1 63  ? -34.56800 -24.76000 -12.21100 1.000 26.63681 ? 63  ILE C C   1 
ATOM   2753 O O   . ILE C 1 63  ? -35.49500 -25.09000 -12.96000 1.000 26.40597 ? 63  ILE C O   1 
ATOM   2754 C CB  . ILE C 1 63  ? -34.15700 -26.88400 -10.90400 1.000 26.00837 ? 63  ILE C CB  1 
ATOM   2755 C CG1 . ILE C 1 63  ? -34.02600 -27.47400 -9.50100  1.000 34.52328 ? 63  ILE C CG1 1 
ATOM   2756 C CG2 . ILE C 1 63  ? -32.87100 -27.16700 -11.67000 1.000 26.74115 ? 63  ILE C CG2 1 
ATOM   2757 C CD1 . ILE C 1 63  ? -33.96200 -28.98300 -9.47400  1.000 34.16904 ? 63  ILE C CD1 1 
ATOM   2758 N N   . PHE C 1 64  ? -33.63500 -23.86600 -12.55400 1.000 25.71616 ? 64  PHE C N   1 
ATOM   2759 C CA  . PHE C 1 64  ? -33.53600 -23.31500 -13.90500 1.000 25.02801 ? 64  PHE C CA  1 
ATOM   2760 C C   . PHE C 1 64  ? -32.20500 -23.74400 -14.51200 1.000 24.63192 ? 64  PHE C C   1 
ATOM   2761 O O   . PHE C 1 64  ? -31.13300 -23.41100 -13.98800 1.000 22.41044 ? 64  PHE C O   1 
ATOM   2762 C CB  . PHE C 1 64  ? -33.70600 -21.79000 -13.90800 1.000 24.79580 ? 64  PHE C CB  1 
ATOM   2763 C CG  . PHE C 1 64  ? -33.46500 -21.14000 -15.25800 1.000 25.15389 ? 64  PHE C CG  1 
ATOM   2764 C CD1 . PHE C 1 64  ? -33.97400 -21.70200 -16.42300 1.000 24.89626 ? 64  PHE C CD1 1 
ATOM   2765 C CD2 . PHE C 1 64  ? -32.76100 -19.94000 -15.35400 1.000 21.83392 ? 64  PHE C CD2 1 
ATOM   2766 C CE1 . PHE C 1 64  ? -33.75200 -21.10600 -17.66700 1.000 22.49730 ? 64  PHE C CE1 1 
ATOM   2767 C CE2 . PHE C 1 64  ? -32.54100 -19.33600 -16.59000 1.000 25.77183 ? 64  PHE C CE2 1 
ATOM   2768 C CZ  . PHE C 1 64  ? -33.02800 -19.92600 -17.75200 1.000 23.54632 ? 64  PHE C CZ  1 
ATOM   2769 N N   . VAL C 1 65  ? -32.28800 -24.54100 -15.57900 1.000 26.69632 ? 65  VAL C N   1 
ATOM   2770 C CA  . VAL C 1 65  ? -31.14300 -24.96400 -16.37700 1.000 22.76664 ? 65  VAL C CA  1 
ATOM   2771 C C   . VAL C 1 65  ? -31.03600 -24.01600 -17.57500 1.000 22.26399 ? 65  VAL C C   1 
ATOM   2772 O O   . VAL C 1 65  ? -31.96300 -23.91900 -18.39000 1.000 23.56927 ? 65  VAL C O   1 
ATOM   2773 C CB  . VAL C 1 65  ? -31.29700 -26.42500 -16.83900 1.000 23.98255 ? 65  VAL C CB  1 
ATOM   2774 C CG1 . VAL C 1 65  ? -30.12100 -26.85300 -17.75300 1.000 21.62593 ? 65  VAL C CG1 1 
ATOM   2775 C CG2 . VAL C 1 65  ? -31.45000 -27.36700 -15.64900 1.000 21.28479 ? 65  VAL C CG2 1 
ATOM   2776 N N   . HIS C 1 66  ? -29.92600 -23.28900 -17.67900 1.000 21.12682 ? 66  HIS C N   1 
ATOM   2777 C CA  . HIS C 1 66  ? -29.61800 -22.52800 -18.88000 1.000 22.55002 ? 66  HIS C CA  1 
ATOM   2778 C C   . HIS C 1 66  ? -28.47400 -23.24600 -19.58500 1.000 23.36744 ? 66  HIS C C   1 
ATOM   2779 O O   . HIS C 1 66  ? -27.35400 -23.28600 -19.05200 1.000 26.10670 ? 66  HIS C O   1 
ATOM   2780 C CB  . HIS C 1 66  ? -29.28400 -21.07000 -18.57900 1.000 17.22518 ? 66  HIS C CB  1 
ATOM   2781 C CG  . HIS C 1 66  ? -29.30000 -20.18600 -19.79100 1.000 23.52449 ? 66  HIS C CG  1 
ATOM   2782 N ND1 . HIS C 1 66  ? -28.90100 -18.86300 -19.76100 1.000 24.65269 ? 66  HIS C ND1 1 
ATOM   2783 C CD2 . HIS C 1 66  ? -29.65900 -20.43800 -21.07500 1.000 22.32803 ? 66  HIS C CD2 1 
ATOM   2784 C CE1 . HIS C 1 66  ? -29.02200 -18.33800 -20.96800 1.000 25.34053 ? 66  HIS C CE1 1 
ATOM   2785 N NE2 . HIS C 1 66  ? -29.47600 -19.27300 -21.78500 1.000 29.57868 ? 66  HIS C NE2 1 
ATOM   2786 N N   . GLY C 1 67  ? -28.75800 -23.81700 -20.73000 1.000 25.29434 ? 67  GLY C N   1 
ATOM   2787 C CA  . GLY C 1 67  ? -27.79000 -24.60900 -21.47200 1.000 23.96481 ? 67  GLY C CA  1 
ATOM   2788 C C   . GLY C 1 67  ? -27.25800 -23.81900 -22.64900 1.000 24.80741 ? 67  GLY C C   1 
ATOM   2789 O O   . GLY C 1 67  ? -28.02200 -23.37600 -23.51100 1.000 25.56318 ? 67  GLY C O   1 
ATOM   2790 N N   . LEU C 1 68  ? -25.94400 -23.62800 -22.67000 1.000 26.26728 ? 68  LEU C N   1 
ATOM   2791 C CA  . LEU C 1 68  ? -25.27300 -22.88300 -23.72800 1.000 25.57246 ? 68  LEU C CA  1 
ATOM   2792 C C   . LEU C 1 68  ? -24.58400 -23.87200 -24.65700 1.000 24.08656 ? 68  LEU C C   1 
ATOM   2793 O O   . LEU C 1 68  ? -23.64900 -24.56600 -24.24600 1.000 19.41731 ? 68  LEU C O   1 
ATOM   2794 C CB  . LEU C 1 68  ? -24.28800 -21.87100 -23.14600 1.000 17.51552 ? 68  LEU C CB  1 
ATOM   2795 C CG  . LEU C 1 68  ? -24.85500 -20.95500 -22.05300 1.000 25.67057 ? 68  LEU C CG  1 
ATOM   2796 C CD1 . LEU C 1 68  ? -23.73300 -20.16700 -21.35000 1.000 18.18227 ? 68  LEU C CD1 1 
ATOM   2797 C CD2 . LEU C 1 68  ? -25.93300 -20.00900 -22.59700 1.000 24.13696 ? 68  LEU C CD2 1 
ATOM   2798 N N   . HIS C 1 69  ? -25.07200 -23.94600 -25.89900 1.000 23.79813 ? 69  HIS C N   1 
ATOM   2799 C CA  . HIS C 1 69  ? -24.69600 -24.97300 -26.85800 1.000 22.61042 ? 69  HIS C CA  1 
ATOM   2800 C C   . HIS C 1 69  ? -24.07300 -24.33800 -28.08900 1.000 23.58424 ? 69  HIS C C   1 
ATOM   2801 O O   . HIS C 1 69  ? -24.31900 -23.16900 -28.39800 1.000 23.24129 ? 69  HIS C O   1 
ATOM   2802 C CB  . HIS C 1 69  ? -25.90800 -25.79500 -27.32000 1.000 23.53603 ? 69  HIS C CB  1 
ATOM   2803 C CG  . HIS C 1 69  ? -26.52900 -26.63000 -26.24900 1.000 23.08159 ? 69  HIS C CG  1 
ATOM   2804 N ND1 . HIS C 1 69  ? -27.76800 -27.21300 -26.39500 1.000 26.42444 ? 69  HIS C ND1 1 
ATOM   2805 C CD2 . HIS C 1 69  ? -26.09000 -26.98400 -25.01600 1.000 30.36921 ? 69  HIS C CD2 1 
ATOM   2806 C CE1 . HIS C 1 69  ? -28.06600 -27.89500 -25.30400 1.000 30.84396 ? 69  HIS C CE1 1 
ATOM   2807 N NE2 . HIS C 1 69  ? -27.06700 -27.77000 -24.44800 1.000 30.95185 ? 69  HIS C NE2 1 
ATOM   2808 N N   . ARG C 1 70  ? -23.26500 -25.13100 -28.78900 1.000 19.81178 ? 70  ARG C N   1 
ATOM   2809 C CA  . ARG C 1 70  ? -22.87100 -24.79300 -30.15100 1.000 24.00460 ? 70  ARG C CA  1 
ATOM   2810 C C   . ARG C 1 70  ? -24.05100 -24.93800 -31.09900 1.000 26.28695 ? 70  ARG C C   1 
ATOM   2811 O O   . ARG C 1 70  ? -24.83200 -25.89200 -30.99600 1.000 25.50325 ? 70  ARG C O   1 
ATOM   2812 C CB  . ARG C 1 70  ? -21.75200 -25.69800 -30.64100 1.000 24.53440 ? 70  ARG C CB  1 
ATOM   2813 C CG  . ARG C 1 70  ? -20.48600 -25.58100 -29.86400 1.000 29.12353 ? 70  ARG C CG  1 
ATOM   2814 C CD  . ARG C 1 70  ? -19.50700 -26.60300 -30.31700 1.000 27.11641 ? 70  ARG C CD  1 
ATOM   2815 N NE  . ARG C 1 70  ? -19.69500 -27.82400 -29.55000 1.000 30.02453 ? 70  ARG C NE  1 
ATOM   2816 C CZ  . ARG C 1 70  ? -19.32500 -29.03600 -29.94100 1.000 32.66564 ? 70  ARG C CZ  1 
ATOM   2817 N NH1 . ARG C 1 70  ? -18.63200 -29.22400 -31.05700 1.000 27.71632 ? 70  ARG C NH1 1 
ATOM   2818 N NH2 . ARG C 1 70  ? -19.65500 -30.08700 -29.18900 1.000 31.15927 ? 70  ARG C NH2 1 
ATOM   2819 N N   . GLU C 1 71  ? -24.16700 -23.98800 -32.03300 1.000 23.86321 ? 71  GLU C N   1 
ATOM   2820 C CA  . GLU C 1 71  ? -25.12200 -24.09100 -33.12500 1.000 27.25494 ? 71  GLU C CA  1 
ATOM   2821 C C   . GLU C 1 71  ? -24.83200 -25.32200 -33.97700 1.000 26.01389 ? 71  GLU C C   1 
ATOM   2822 O O   . GLU C 1 71  ? -23.69200 -25.78200 -34.08100 1.000 20.14645 ? 71  GLU C O   1 
ATOM   2823 C CB  . GLU C 1 71  ? -25.05600 -22.85300 -34.02700 1.000 22.02564 ? 71  GLU C CB  1 
ATOM   2824 C CG  . GLU C 1 71  ? -25.68500 -21.61500 -33.42100 1.000 29.83763 ? 71  GLU C CG  1 
ATOM   2825 C CD  . GLU C 1 71  ? -25.59700 -20.39000 -34.33100 1.000 34.17145 ? 71  GLU C CD  1 
ATOM   2826 O OE1 . GLU C 1 71  ? -24.99800 -20.48700 -35.43200 1.000 36.35209 ? 71  GLU C OE1 1 
ATOM   2827 O OE2 . GLU C 1 71  ? -26.11200 -19.32300 -33.93200 1.000 38.16751 ? 71  GLU C OE2 1 
ATOM   2828 N N   . GLY C 1 72  ? -25.88700 -25.83800 -34.61000 1.000 28.17038 ? 72  GLY C N   1 
ATOM   2829 C CA  . GLY C 1 72  ? -25.74700 -26.83900 -35.64500 1.000 26.10638 ? 72  GLY C CA  1 
ATOM   2830 C C   . GLY C 1 72  ? -26.53900 -28.11400 -35.46000 1.000 29.50117 ? 72  GLY C C   1 
ATOM   2831 O O   . GLY C 1 72  ? -26.50000 -28.98200 -36.33500 1.000 28.02895 ? 72  GLY C O   1 
ATOM   2832 N N   . ARG C 1 73  ? -27.26200 -28.26000 -34.35200 1.000 27.86020 ? 73  ARG C N   1 
ATOM   2833 C CA  . ARG C 1 73  ? -28.05900 -29.46400 -34.15100 1.000 27.64150 ? 73  ARG C CA  1 
ATOM   2834 C C   . ARG C 1 73  ? -29.50200 -29.22300 -34.56300 1.000 28.41218 ? 73  ARG C C   1 
ATOM   2835 O O   . ARG C 1 73  ? -29.94100 -28.08400 -34.72400 1.000 29.28193 ? 73  ARG C O   1 
ATOM   2836 C CB  . ARG C 1 73  ? -27.97700 -29.93400 -32.69400 1.000 28.33845 ? 73  ARG C CB  1 
ATOM   2837 C CG  . ARG C 1 73  ? -26.52800 -30.12800 -32.25200 1.000 30.25932 ? 73  ARG C CG  1 
ATOM   2838 C CD  . ARG C 1 73  ? -26.38100 -31.12100 -31.12400 1.000 29.86854 ? 73  ARG C CD  1 
ATOM   2839 N NE  . ARG C 1 73  ? -24.98000 -31.30100 -30.76700 1.000 35.03430 ? 73  ARG C NE  1 
ATOM   2840 C CZ  . ARG C 1 73  ? -24.34000 -30.56000 -29.87200 1.000 36.03414 ? 73  ARG C CZ  1 
ATOM   2841 N NH1 . ARG C 1 73  ? -24.95600 -29.60100 -29.20000 1.000 30.05061 ? 73  ARG C NH1 1 
ATOM   2842 N NH2 . ARG C 1 73  ? -23.05600 -30.79600 -29.63400 1.000 30.62251 ? 73  ARG C NH2 1 
ATOM   2843 N N   . SER C 1 74  ? -30.23500 -30.31500 -34.74900 1.000 28.31015 ? 74  SER C N   1 
ATOM   2844 C CA  . SER C 1 74  ? -31.61200 -30.19500 -35.20000 1.000 28.12854 ? 74  SER C CA  1 
ATOM   2845 C C   . SER C 1 74  ? -32.53200 -29.88600 -34.03000 1.000 23.74742 ? 74  SER C C   1 
ATOM   2846 O O   . SER C 1 74  ? -32.21400 -30.14900 -32.86900 1.000 28.17937 ? 74  SER C O   1 
ATOM   2847 C CB  . SER C 1 74  ? -32.07000 -31.47600 -35.89800 1.000 24.28099 ? 74  SER C CB  1 
ATOM   2848 O OG  . SER C 1 74  ? -32.39800 -32.45100 -34.93300 1.000 24.31363 ? 74  SER C OG  1 
ATOM   2849 N N   . ALA C 1 75  ? -33.68100 -29.29200 -34.35200 1.000 22.21730 ? 75  ALA C N   1 
ATOM   2850 C CA  . ALA C 1 75  ? -34.68800 -29.01400 -33.33700 1.000 24.42761 ? 75  ALA C CA  1 
ATOM   2851 C C   . ALA C 1 75  ? -35.13800 -30.28500 -32.65000 1.000 25.27761 ? 75  ALA C C   1 
ATOM   2852 O O   . ALA C 1 75  ? -35.45100 -30.27100 -31.45700 1.000 25.40576 ? 75  ALA C O   1 
ATOM   2853 C CB  . ALA C 1 75  ? -35.89900 -28.33100 -33.97200 1.000 25.78457 ? 75  ALA C CB  1 
ATOM   2854 N N   . ASP C 1 76  ? -35.17600 -31.38400 -33.39600 1.000 25.66509 ? 76  ASP C N   1 
ATOM   2855 C CA  . ASP C 1 76  ? -35.58000 -32.66700 -32.84300 1.000 29.36850 ? 76  ASP C CA  1 
ATOM   2856 C C   . ASP C 1 76  ? -34.59400 -33.14600 -31.78900 1.000 29.34652 ? 76  ASP C C   1 
ATOM   2857 O O   . ASP C 1 76  ? -34.99500 -33.57400 -30.70300 1.000 26.87952 ? 76  ASP C O   1 
ATOM   2858 C CB  . ASP C 1 76  ? -35.69700 -33.69700 -33.95800 1.000 31.80194 ? 76  ASP C CB  1 
ATOM   2859 C CG  . ASP C 1 76  ? -36.26100 -34.99000 -33.46900 1.000 42.54564 ? 76  ASP C CG  1 
ATOM   2860 O OD1 . ASP C 1 76  ? -35.47000 -35.81400 -32.95900 1.000 47.21739 ? 76  ASP C OD1 1 
ATOM   2861 O OD2 . ASP C 1 76  ? -37.50300 -35.15700 -33.54500 1.000 51.24931 ? 76  ASP C OD2 1 
ATOM   2862 N N   . LEU C 1 77  ? -33.28900 -33.10400 -32.09500 1.000 28.64731 ? 77  LEU C N   1 
ATOM   2863 C CA  . LEU C 1 77  ? -32.31500 -33.51200 -31.08900 1.000 29.86031 ? 77  LEU C CA  1 
ATOM   2864 C C   . LEU C 1 77  ? -32.43300 -32.63400 -29.85600 1.000 24.38630 ? 77  LEU C C   1 
ATOM   2865 O O   . LEU C 1 77  ? -32.43100 -33.12700 -28.72400 1.000 27.13726 ? 77  LEU C O   1 
ATOM   2866 C CB  . LEU C 1 77  ? -30.88600 -33.45200 -31.65200 1.000 28.10374 ? 77  LEU C CB  1 
ATOM   2867 C CG  . LEU C 1 77  ? -29.74700 -33.87600 -30.69400 1.000 35.13252 ? 77  LEU C CG  1 
ATOM   2868 C CD1 . LEU C 1 77  ? -28.54300 -34.43500 -31.46100 1.000 33.27332 ? 77  LEU C CD1 1 
ATOM   2869 C CD2 . LEU C 1 77  ? -29.28000 -32.72700 -29.71400 1.000 36.04691 ? 77  LEU C CD2 1 
ATOM   2870 N N   . LYS C 1 78  ? -32.54000 -31.32000 -30.06400 1.000 24.40812 ? 78  LYS C N   1 
ATOM   2871 C CA  . LYS C 1 78  ? -32.56700 -30.39900 -28.93900 1.000 24.47133 ? 78  LYS C CA  1 
ATOM   2872 C C   . LYS C 1 78  ? -33.78000 -30.62200 -28.04500 1.000 25.33895 ? 78  LYS C C   1 
ATOM   2873 O O   . LYS C 1 78  ? -33.67700 -30.47400 -26.82000 1.000 21.38285 ? 78  LYS C O   1 
ATOM   2874 C CB  . LYS C 1 78  ? -32.52100 -28.95900 -29.44300 1.000 23.47764 ? 78  LYS C CB  1 
ATOM   2875 C CG  . LYS C 1 78  ? -31.14800 -28.53900 -29.90200 1.000 27.17204 ? 78  LYS C CG  1 
ATOM   2876 C CD  . LYS C 1 78  ? -31.13200 -27.08000 -30.35900 1.000 26.24627 ? 78  LYS C CD  1 
ATOM   2877 C CE  . LYS C 1 78  ? -31.73900 -26.93400 -31.73600 1.000 25.16128 ? 78  LYS C CE  1 
ATOM   2878 N NZ  . LYS C 1 78  ? -31.71100 -25.51800 -32.15900 1.000 24.18084 ? 78  LYS C NZ  1 
ATOM   2879 N N   . GLY C 1 79  ? -34.91900 -31.01100 -28.62400 1.000 23.43973 ? 79  GLY C N   1 
ATOM   2880 C CA  . GLY C 1 79  ? -36.08500 -31.29300 -27.80700 1.000 21.18236 ? 79  GLY C CA  1 
ATOM   2881 C C   . GLY C 1 79  ? -35.91100 -32.53500 -26.95900 1.000 23.53648 ? 79  GLY C C   1 
ATOM   2882 O O   . GLY C 1 79  ? -36.24400 -32.54000 -25.76600 1.000 23.74320 ? 79  GLY C O   1 
ATOM   2883 N N   . GLN C 1 80  ? -35.38400 -33.60200 -27.56300 1.000 22.84216 ? 80  GLN C N   1 
ATOM   2884 C CA  . GLN C 1 80  ? -35.03900 -34.81000 -26.81600 1.000 22.68298 ? 80  GLN C CA  1 
ATOM   2885 C C   . GLN C 1 80  ? -34.07100 -34.49800 -25.68600 1.000 23.78131 ? 80  GLN C C   1 
ATOM   2886 O O   . GLN C 1 80  ? -34.22100 -35.00600 -24.56900 1.000 26.03688 ? 80  GLN C O   1 
ATOM   2887 C CB  . GLN C 1 80  ? -34.41000 -35.84700 -27.74800 1.000 22.21849 ? 80  GLN C CB  1 
ATOM   2888 C CG  . GLN C 1 80  ? -35.33600 -36.46900 -28.78400 1.000 30.21190 ? 80  GLN C CG  1 
ATOM   2889 C CD  . GLN C 1 80  ? -34.62500 -37.55900 -29.59100 1.000 33.63410 ? 80  GLN C CD  1 
ATOM   2890 O OE1 . GLN C 1 80  ? -34.53800 -37.49000 -30.82300 1.000 37.35222 ? 80  GLN C OE1 1 
ATOM   2891 N NE2 . GLN C 1 80  ? -34.07300 -38.54100 -28.89000 1.000 37.56678 ? 80  GLN C NE2 1 
ATOM   2892 N N   . LEU C 1 81  ? -33.06400 -33.66900 -25.96100 1.000 23.86635 ? 81  LEU C N   1 
ATOM   2893 C CA  . LEU C 1 81  ? -32.06500 -33.36500 -24.94500 1.000 23.45996 ? 81  LEU C CA  1 
ATOM   2894 C C   . LEU C 1 81  ? -32.67400 -32.57200 -23.79400 1.000 26.25194 ? 81  LEU C C   1 
ATOM   2895 O O   . LEU C 1 81  ? -32.37100 -32.83500 -22.62200 1.000 28.79185 ? 81  LEU C O   1 
ATOM   2896 C CB  . LEU C 1 81  ? -30.89600 -32.61600 -25.58300 1.000 23.87189 ? 81  LEU C CB  1 
ATOM   2897 C CG  . LEU C 1 81  ? -29.69400 -32.24800 -24.71600 1.000 26.48094 ? 81  LEU C CG  1 
ATOM   2898 C CD1 . LEU C 1 81  ? -29.17300 -33.41800 -23.89800 1.000 22.13373 ? 81  LEU C CD1 1 
ATOM   2899 C CD2 . LEU C 1 81  ? -28.59600 -31.68700 -25.60800 1.000 27.52899 ? 81  LEU C CD2 1 
ATOM   2900 N N   . ALA C 1 82  ? -33.55200 -31.61300 -24.09500 1.000 23.60451 ? 82  ALA C N   1 
ATOM   2901 C CA  . ALA C 1 82  ? -34.22000 -30.87900 -23.02200 1.000 25.90000 ? 82  ALA C CA  1 
ATOM   2902 C C   . ALA C 1 82  ? -35.15000 -31.78800 -22.22400 1.000 28.32999 ? 82  ALA C C   1 
ATOM   2903 O O   . ALA C 1 82  ? -35.20800 -31.70100 -20.99100 1.000 28.42989 ? 82  ALA C O   1 
ATOM   2904 C CB  . ALA C 1 82  ? -35.00700 -29.69200 -23.59100 1.000 25.77066 ? 82  ALA C CB  1 
ATOM   2905 N N   . GLN C 1 83  ? -35.89800 -32.65100 -22.91100 1.000 27.99475 ? 83  GLN C N   1 
ATOM   2906 C CA  . GLN C 1 83  ? -36.78000 -33.57800 -22.21400 1.000 29.29298 ? 83  GLN C CA  1 
ATOM   2907 C C   . GLN C 1 83  ? -35.98800 -34.54800 -21.34900 1.000 27.75339 ? 83  GLN C C   1 
ATOM   2908 O O   . GLN C 1 83  ? -36.37600 -34.81900 -20.21100 1.000 27.36299 ? 83  GLN C O   1 
ATOM   2909 C CB  . GLN C 1 83  ? -37.65100 -34.33700 -23.21100 1.000 28.80706 ? 83  GLN C CB  1 
ATOM   2910 C CG  . GLN C 1 83  ? -38.74300 -35.15000 -22.55100 1.000 29.37186 ? 83  GLN C CG  1 
ATOM   2911 C CD  . GLN C 1 83  ? -39.76000 -34.28900 -21.80700 1.000 35.52556 ? 83  GLN C CD  1 
ATOM   2912 O OE1 . GLN C 1 83  ? -39.84200 -34.32700 -20.57800 1.000 40.53249 ? 83  GLN C OE1 1 
ATOM   2913 N NE2 . GLN C 1 83  ? -40.52800 -33.50100 -22.54800 1.000 36.36602 ? 83  GLN C NE2 1 
ATOM   2914 N N   . ARG C 1 84  ? -34.85800 -35.05800 -21.85600 1.000 27.19721 ? 84  ARG C N   1 
ATOM   2915 C CA  . ARG C 1 84  ? -34.05500 -35.97400 -21.05200 1.000 27.90246 ? 84  ARG C CA  1 
ATOM   2916 C C   . ARG C 1 84  ? -33.45500 -35.27300 -19.84500 1.000 29.14728 ? 84  ARG C C   1 
ATOM   2917 O O   . ARG C 1 84  ? -33.28700 -35.89200 -18.78900 1.000 30.66313 ? 84  ARG C O   1 
ATOM   2918 C CB  . ARG C 1 84  ? -32.95400 -36.62100 -21.88900 1.000 25.44337 ? 84  ARG C CB  1 
ATOM   2919 C CG  . ARG C 1 84  ? -32.61300 -38.02800 -21.40600 1.000 36.38612 ? 84  ARG C CG  1 
ATOM   2920 C CD  . ARG C 1 84  ? -31.12400 -38.35700 -21.40000 1.000 39.70663 ? 84  ARG C CD  1 
ATOM   2921 N NE  . ARG C 1 84  ? -30.85900 -39.50800 -20.53500 1.000 48.22726 ? 84  ARG C NE  1 
ATOM   2922 C CZ  . ARG C 1 84  ? -29.79400 -40.30200 -20.59700 1.000 48.75225 ? 84  ARG C CZ  1 
ATOM   2923 N NH1 . ARG C 1 84  ? -28.87900 -40.16500 -21.54100 1.000 45.12429 ? 84  ARG C NH1 1 
ATOM   2924 N NH2 . ARG C 1 84  ? -29.64600 -41.26200 -19.68300 1.000 50.75029 ? 84  ARG C NH2 1 
ATOM   2925 N N   . ILE C 1 85  ? -33.15000 -33.98500 -19.96000 1.000 24.58389 ? 85  ILE C N   1 
ATOM   2926 C CA  . ILE C 1 85  ? -32.62200 -33.26600 -18.81100 1.000 25.96534 ? 85  ILE C CA  1 
ATOM   2927 C C   . ILE C 1 85  ? -33.71700 -33.06000 -17.76600 1.000 27.18016 ? 85  ILE C C   1 
ATOM   2928 O O   . ILE C 1 85  ? -33.50000 -33.27400 -16.56800 1.000 30.50616 ? 85  ILE C O   1 
ATOM   2929 C CB  . ILE C 1 85  ? -31.97400 -31.95000 -19.26800 1.000 23.26977 ? 85  ILE C CB  1 
ATOM   2930 C CG1 . ILE C 1 85  ? -30.60900 -32.28400 -19.89500 1.000 27.55308 ? 85  ILE C CG1 1 
ATOM   2931 C CG2 . ILE C 1 85  ? -31.84400 -31.00100 -18.10300 1.000 22.23948 ? 85  ILE C CG2 1 
ATOM   2932 C CD1 . ILE C 1 85  ? -29.96200 -31.17000 -20.66900 1.000 21.95120 ? 85  ILE C CD1 1 
ATOM   2933 N N   . VAL C 1 86  ? -34.91600 -32.67100 -18.20100 1.000 27.02021 ? 86  VAL C N   1 
ATOM   2934 C CA  . VAL C 1 86  ? -36.04500 -32.59800 -17.27300 1.000 29.66944 ? 86  VAL C CA  1 
ATOM   2935 C C   . VAL C 1 86  ? -36.18600 -33.92800 -16.53000 1.000 32.50017 ? 86  VAL C C   1 
ATOM   2936 O O   . VAL C 1 86  ? -36.14400 -33.98100 -15.28700 1.000 28.55996 ? 86  VAL C O   1 
ATOM   2937 C CB  . VAL C 1 86  ? -37.33700 -32.22900 -18.02500 1.000 29.62705 ? 86  VAL C CB  1 
ATOM   2938 C CG1 . VAL C 1 86  ? -38.53700 -32.44000 -17.14900 1.000 29.63197 ? 86  VAL C CG1 1 
ATOM   2939 C CG2 . VAL C 1 86  ? -37.29000 -30.75900 -18.51700 1.000 27.78827 ? 86  VAL C CG2 1 
ATOM   2940 N N   . ASP C 1 87  ? -36.31300 -35.02500 -17.30200 1.000 32.21354 ? 87  ASP C N   1 
ATOM   2941 C CA  . ASP C 1 87  ? -36.37400 -36.39100 -16.77700 1.000 33.06317 ? 87  ASP C CA  1 
ATOM   2942 C C   . ASP C 1 87  ? -35.36600 -36.67200 -15.66800 1.000 35.25317 ? 87  ASP C C   1 
ATOM   2943 O O   . ASP C 1 87  ? -35.73800 -36.95400 -14.51900 1.000 30.89169 ? 87  ASP C O   1 
ATOM   2944 C CB  . ASP C 1 87  ? -36.14600 -37.35500 -17.94300 1.000 33.56034 ? 87  ASP C CB  1 
ATOM   2945 C CG  . ASP C 1 87  ? -37.37500 -37.59900 -18.77200 1.000 42.65870 ? 87  ASP C CG  1 
ATOM   2946 O OD1 . ASP C 1 87  ? -38.40300 -37.01400 -18.48400 1.000 36.25116 ? 87  ASP C OD1 1 
ATOM   2947 O OD2 . ASP C 1 87  ? -37.29300 -38.35000 -19.77400 1.000 48.20832 ? 87  ASP C OD2 1 
ATOM   2948 N N   . ASP C 1 88  ? -34.08700 -36.56600 -16.02400 1.000 32.68768 ? 88  ASP C N   1 
ATOM   2949 C CA  . ASP C 1 88  ? -32.97400 -37.06600 -15.23000 1.000 33.70811 ? 88  ASP C CA  1 
ATOM   2950 C C   . ASP C 1 88  ? -32.54600 -36.12400 -14.11300 1.000 33.45961 ? 88  ASP C C   1 
ATOM   2951 O O   . ASP C 1 88  ? -31.95600 -36.57500 -13.11400 1.000 30.52065 ? 88  ASP C O   1 
ATOM   2952 C CB  . ASP C 1 88  ? -31.78400 -37.34200 -16.15400 1.000 32.44992 ? 88  ASP C CB  1 
ATOM   2953 C CG  . ASP C 1 88  ? -32.02700 -38.56400 -17.05600 1.000 40.35035 ? 88  ASP C CG  1 
ATOM   2954 O OD1 . ASP C 1 88  ? -33.14100 -39.15200 -17.01500 1.000 33.71988 ? 88  ASP C OD1 1 
ATOM   2955 O OD2 . ASP C 1 88  ? -31.08600 -38.94700 -17.78400 1.000 36.79124 ? 88  ASP C OD2 1 
ATOM   2956 N N   . VAL C 1 89  ? -32.80600 -34.82600 -14.26900 1.000 32.34077 ? 89  VAL C N   1 
ATOM   2957 C CA  . VAL C 1 89  ? -32.61000 -33.90300 -13.15600 1.000 32.37940 ? 89  VAL C CA  1 
ATOM   2958 C C   . VAL C 1 89  ? -33.70900 -34.09500 -12.11700 1.000 34.41550 ? 89  VAL C C   1 
ATOM   2959 O O   . VAL C 1 89  ? -33.45700 -34.01800 -10.90600 1.000 30.34647 ? 89  VAL C O   1 
ATOM   2960 C CB  . VAL C 1 89  ? -32.53800 -32.45000 -13.65500 1.000 29.94160 ? 89  VAL C CB  1 
ATOM   2961 C CG1 . VAL C 1 89  ? -32.58000 -31.48600 -12.48400 1.000 27.83793 ? 89  VAL C CG1 1 
ATOM   2962 C CG2 . VAL C 1 89  ? -31.25400 -32.22900 -14.45300 1.000 31.25439 ? 89  VAL C CG2 1 
ATOM   2963 N N   . SER C 1 90  ? -34.93400 -34.38600 -12.57200 1.000 30.94098 ? 90  SER C N   1 
ATOM   2964 C CA  . SER C 1 90  ? -36.02300 -34.67500 -11.64700 1.000 33.96976 ? 90  SER C CA  1 
ATOM   2965 C C   . SER C 1 90  ? -35.70900 -35.89500 -10.78800 1.000 36.15400 ? 90  SER C C   1 
ATOM   2966 O O   . SER C 1 90  ? -35.90300 -35.87700 -9.56800  1.000 32.56233 ? 90  SER C O   1 
ATOM   2967 C CB  . SER C 1 90  ? -37.31700 -34.90100 -12.41400 1.000 31.76388 ? 90  SER C CB  1 
ATOM   2968 O OG  . SER C 1 90  ? -38.33400 -35.26800 -11.50900 1.000 41.46701 ? 90  SER C OG  1 
ATOM   2969 N N   . VAL C 1 91  ? -35.22900 -36.97000 -11.41700 1.000 33.88681 ? 91  VAL C N   1 
ATOM   2970 C CA  . VAL C 1 91  ? -34.88600 -38.17600 -10.67300 1.000 33.56526 ? 91  VAL C CA  1 
ATOM   2971 C C   . VAL C 1 91  ? -33.67900 -37.92000 -9.78100  1.000 36.43431 ? 91  VAL C C   1 
ATOM   2972 O O   . VAL C 1 91  ? -33.69100 -38.24900 -8.58800  1.000 37.17307 ? 91  VAL C O   1 
ATOM   2973 C CB  . VAL C 1 91  ? -34.64900 -39.34900 -11.64000 1.000 33.83687 ? 91  VAL C CB  1 
ATOM   2974 C CG1 . VAL C 1 91  ? -33.90000 -40.46100 -10.94100 1.000 34.73293 ? 91  VAL C CG1 1 
ATOM   2975 C CG2 . VAL C 1 91  ? -35.98000 -39.84900 -12.17800 1.000 30.08189 ? 91  VAL C CG2 1 
ATOM   2976 N N   . ALA C 1 92  ? -32.64100 -37.27500 -10.33100 1.000 36.40986 ? 92  ALA C N   1 
ATOM   2977 C CA  . ALA C 1 92  ? -31.39500 -37.08600 -9.59000  1.000 31.52106 ? 92  ALA C CA  1 
ATOM   2978 C C   . ALA C 1 92  ? -31.53800 -36.10200 -8.43500  1.000 38.40984 ? 92  ALA C C   1 
ATOM   2979 O O   . ALA C 1 92  ? -30.77800 -36.17800 -7.46400  1.000 37.84876 ? 92  ALA C O   1 
ATOM   2980 C CB  . ALA C 1 92  ? -30.28900 -36.61900 -10.53600 1.000 32.69298 ? 92  ALA C CB  1 
ATOM   2981 N N   . ALA C 1 93  ? -32.45900 -35.14700 -8.52800  1.000 35.28325 ? 93  ALA C N   1 
ATOM   2982 C CA  . ALA C 1 93  ? -32.63300 -34.17300 -7.45900  1.000 36.79479 ? 93  ALA C CA  1 
ATOM   2983 C C   . ALA C 1 93  ? -33.82300 -34.50400 -6.57000  1.000 35.09350 ? 93  ALA C C   1 
ATOM   2984 O O   . ALA C 1 93  ? -34.04100 -33.82900 -5.55400  1.000 35.37326 ? 93  ALA C O   1 
ATOM   2985 C CB  . ALA C 1 93  ? -32.78500 -32.76400 -8.04700  1.000 37.53350 ? 93  ALA C CB  1 
ATOM   2986 N N   . GLU C 1 94  ? -34.58100 -35.53800 -6.92100  1.000 33.34120 ? 94  GLU C N   1 
ATOM   2987 C CA  . GLU C 1 94  ? -35.76000 -35.93500 -6.16700  1.000 38.50454 ? 94  GLU C CA  1 
ATOM   2988 C C   . GLU C 1 94  ? -36.68300 -34.73100 -5.99200  1.000 43.42499 ? 94  GLU C C   1 
ATOM   2989 O O   . GLU C 1 94  ? -37.12100 -34.39300 -4.89100  1.000 41.73557 ? 94  GLU C O   1 
ATOM   2990 C CB  . GLU C 1 94  ? -35.35100 -36.55800 -4.83300  1.000 39.50275 ? 94  GLU C CB  1 
ATOM   2991 C CG  . GLU C 1 94  ? -34.85600 -38.00300 -4.97700  1.000 40.70871 ? 94  GLU C CG  1 
ATOM   2992 C CD  . GLU C 1 94  ? -34.33700 -38.60000 -3.66600  1.000 57.75956 ? 94  GLU C CD  1 
ATOM   2993 O OE1 . GLU C 1 94  ? -33.30700 -38.11300 -3.14100  1.000 60.51567 ? 94  GLU C OE1 1 
ATOM   2994 O OE2 . GLU C 1 94  ? -34.95500 -39.57200 -3.16800  1.000 62.24798 ? 94  GLU C OE2 1 
ATOM   2995 N N   . ILE C 1 95  ? -36.94900 -34.06400 -7.12000  1.000 38.82771 ? 95  ILE C N   1 
ATOM   2996 C CA  . ILE C 1 95  ? -37.75100 -32.85000 -7.19200  1.000 32.57666 ? 95  ILE C CA  1 
ATOM   2997 C C   . ILE C 1 95  ? -38.71200 -33.01300 -8.35600  1.000 38.22416 ? 95  ILE C C   1 
ATOM   2998 O O   . ILE C 1 95  ? -38.33400 -33.52200 -9.42100  1.000 39.62862 ? 95  ILE C O   1 
ATOM   2999 C CB  . ILE C 1 95  ? -36.88300 -31.58500 -7.39200  1.000 40.66988 ? 95  ILE C CB  1 
ATOM   3000 C CG1 . ILE C 1 95  ? -36.17600 -31.17400 -6.10200  1.000 45.08125 ? 95  ILE C CG1 1 
ATOM   3001 C CG2 . ILE C 1 95  ? -37.71600 -30.41000 -7.90800  1.000 33.44057 ? 95  ILE C CG2 1 
ATOM   3002 C CD1 . ILE C 1 95  ? -35.35300 -29.90900 -6.26700  1.000 42.66198 ? 95  ILE C CD1 1 
ATOM   3003 N N   . ASP C 1 96  ? -39.94700 -32.56700 -8.15900  1.000 36.74256 ? 96  ASP C N   1 
ATOM   3004 C CA  . ASP C 1 96  ? -40.98700 -32.81100 -9.14200  1.000 39.26813 ? 96  ASP C CA  1 
ATOM   3005 C C   . ASP C 1 96  ? -40.80400 -31.92600 -10.37500 1.000 37.81348 ? 96  ASP C C   1 
ATOM   3006 O O   . ASP C 1 96  ? -40.37500 -30.77100 -10.29400 1.000 33.32666 ? 96  ASP C O   1 
ATOM   3007 C CB  . ASP C 1 96  ? -42.35700 -32.62000 -8.48800  1.000 40.93032 ? 96  ASP C CB  1 
ATOM   3008 C CG  . ASP C 1 96  ? -43.46600 -32.36700 -9.48000  1.000 48.81526 ? 96  ASP C CG  1 
ATOM   3009 O OD1 . ASP C 1 96  ? -43.58000 -33.12100 -10.47500 1.000 51.23727 ? 96  ASP C OD1 1 
ATOM   3010 O OD2 . ASP C 1 96  ? -44.22400 -31.40700 -9.25300  1.000 54.66120 ? 96  ASP C OD2 1 
ATOM   3011 N N   . ARG C 1 97  ? -41.14600 -32.50300 -11.52300 1.000 36.21348 ? 97  ARG C N   1 
ATOM   3012 C CA  . ARG C 1 97  ? -40.84800 -31.93300 -12.83300 1.000 36.65223 ? 97  ARG C CA  1 
ATOM   3013 C C   . ARG C 1 97  ? -41.45700 -30.55500 -13.04800 1.000 33.24968 ? 97  ARG C C   1 
ATOM   3014 O O   . ARG C 1 97  ? -40.98400 -29.80600 -13.90200 1.000 31.71046 ? 97  ARG C O   1 
ATOM   3015 C CB  . ARG C 1 97  ? -41.38000 -32.88500 -13.87800 1.000 35.51837 ? 97  ARG C CB  1 
ATOM   3016 C CG  . ARG C 1 97  ? -40.45400 -33.97000 -14.20900 1.000 44.52699 ? 97  ARG C CG  1 
ATOM   3017 C CD  . ARG C 1 97  ? -41.21900 -34.80000 -15.18100 1.000 52.44750 ? 97  ARG C CD  1 
ATOM   3018 N NE  . ARG C 1 97  ? -40.48500 -35.00200 -16.41400 1.000 53.76011 ? 97  ARG C NE  1 
ATOM   3019 C CZ  . ARG C 1 97  ? -40.72700 -35.98100 -17.27500 1.000 58.17088 ? 97  ARG C CZ  1 
ATOM   3020 N NH1 . ARG C 1 97  ? -41.55500 -36.97000 -16.98200 1.000 62.52944 ? 97  ARG C NH1 1 
ATOM   3021 N NH2 . ARG C 1 97  ? -40.12700 -35.96800 -18.46700 1.000 51.44847 ? 97  ARG C NH2 1 
ATOM   3022 N N   . LYS C 1 98  ? -42.51900 -30.21100 -12.32600 1.000 34.64724 ? 98  LYS C N   1 
ATOM   3023 C CA  . LYS C 1 98  ? -43.10400 -28.89000 -12.51700 1.000 36.49365 ? 98  LYS C CA  1 
ATOM   3024 C C   . LYS C 1 98  ? -42.26300 -27.78700 -11.89000 1.000 31.28353 ? 98  LYS C C   1 
ATOM   3025 O O   . LYS C 1 98  ? -42.60100 -26.60000 -12.03800 1.000 29.58115 ? 98  LYS C O   1 
ATOM   3026 C CB  . LYS C 1 98  ? -44.54000 -28.88300 -11.98100 1.000 37.68556 ? 98  LYS C CB  1 
ATOM   3027 C CG  . LYS C 1 98  ? -45.42100 -29.99600 -12.59100 1.000 41.38360 ? 98  LYS C CG  1 
ATOM   3028 C CD  . LYS C 1 98  ? -46.08600 -30.90900 -11.54000 1.000 51.92036 ? 98  LYS C CD  1 
ATOM   3029 C CE  . LYS C 1 98  ? -47.35700 -30.29400 -10.95500 1.000 46.59368 ? 98  LYS C CE  1 
ATOM   3030 N NZ  . LYS C 1 98  ? -48.31100 -31.36100 -10.50000 1.000 45.55882 ? 98  LYS C NZ  1 
ATOM   3031 N N   . HIS C 1 99  ? -41.16200 -28.15000 -11.23400 1.000 28.94779 ? 99  HIS C N   1 
ATOM   3032 C CA  . HIS C 1 99  ? -40.21300 -27.18900 -10.69900 1.000 31.68933 ? 99  HIS C CA  1 
ATOM   3033 C C   . HIS C 1 99  ? -39.04500 -26.93100 -11.64400 1.000 31.18658 ? 99  HIS C C   1 
ATOM   3034 O O   . HIS C 1 99  ? -38.18000 -26.10400 -11.32500 1.000 28.84308 ? 99  HIS C O   1 
ATOM   3035 C CB  . HIS C 1 99  ? -39.67600 -27.67200 -9.34400  1.000 31.05044 ? 99  HIS C CB  1 
ATOM   3036 C CG  . HIS C 1 99  ? -40.67400 -27.58000 -8.22800  1.000 32.12738 ? 99  HIS C CG  1 
ATOM   3037 N ND1 . HIS C 1 99  ? -41.21800 -26.38400 -7.80700  1.000 38.33634 ? 99  HIS C ND1 1 
ATOM   3038 C CD2 . HIS C 1 99  ? -41.22900 -28.54000 -7.44900  1.000 33.61108 ? 99  HIS C CD2 1 
ATOM   3039 C CE1 . HIS C 1 99  ? -42.07100 -26.61200 -6.82300  1.000 34.63239 ? 99  HIS C CE1 1 
ATOM   3040 N NE2 . HIS C 1 99  ? -42.09500 -27.91100 -6.58700  1.000 37.50459 ? 99  HIS C NE2 1 
ATOM   3041 N N   . ILE C 1 100 ? -38.99700 -27.60900 -12.79100 1.000 27.96871 ? 100 ILE C N   1 
ATOM   3042 C CA  . ILE C 1 100 ? -37.80300 -27.64200 -13.63500 1.000 29.29613 ? 100 ILE C CA  1 
ATOM   3043 C C   . ILE C 1 100 ? -38.03700 -26.83000 -14.90400 1.000 24.78575 ? 100 ILE C C   1 
ATOM   3044 O O   . ILE C 1 100 ? -38.93500 -27.13900 -15.70600 1.000 23.94245 ? 100 ILE C O   1 
ATOM   3045 C CB  . ILE C 1 100 ? -37.38800 -29.08200 -13.96800 1.000 28.78480 ? 100 ILE C CB  1 
ATOM   3046 C CG1 . ILE C 1 100 ? -37.14500 -29.86100 -12.67200 1.000 33.01875 ? 100 ILE C CG1 1 
ATOM   3047 C CG2 . ILE C 1 100 ? -36.13600 -29.07500 -14.83200 1.000 25.63367 ? 100 ILE C CG2 1 
ATOM   3048 C CD1 . ILE C 1 100 ? -36.86400 -31.31100 -12.88400 1.000 34.55939 ? 100 ILE C CD1 1 
ATOM   3049 N N   . TRP C 1 101 ? -37.19900 -25.81000 -15.09100 1.000 26.58984 ? 101 TRP C N   1 
ATOM   3050 C CA  . TRP C 1 101 ? -37.16200 -24.98000 -16.29000 1.000 25.90216 ? 101 TRP C CA  1 
ATOM   3051 C C   . TRP C 1 101 ? -35.83200 -25.18500 -17.00100 1.000 25.44968 ? 101 TRP C C   1 
ATOM   3052 O O   . TRP C 1 101 ? -34.77800 -25.19900 -16.35300 1.000 23.52372 ? 101 TRP C O   1 
ATOM   3053 C CB  . TRP C 1 101 ? -37.32300 -23.49300 -15.94600 1.000 24.96431 ? 101 TRP C CB  1 
ATOM   3054 C CG  . TRP C 1 101 ? -38.59700 -23.12600 -15.21700 1.000 24.57478 ? 101 TRP C CG  1 
ATOM   3055 C CD1 . TRP C 1 101 ? -39.22500 -23.83300 -14.22300 1.000 24.83181 ? 101 TRP C CD1 1 
ATOM   3056 C CD2 . TRP C 1 101 ? -39.38400 -21.94800 -15.42500 1.000 27.24893 ? 101 TRP C CD2 1 
ATOM   3057 N NE1 . TRP C 1 101 ? -40.35500 -23.16500 -13.81000 1.000 27.45083 ? 101 TRP C NE1 1 
ATOM   3058 C CE2 . TRP C 1 101 ? -40.47300 -22.00400 -14.53100 1.000 23.99832 ? 101 TRP C CE2 1 
ATOM   3059 C CE3 . TRP C 1 101 ? -39.26600 -20.84000 -16.27300 1.000 25.55924 ? 101 TRP C CE3 1 
ATOM   3060 C CZ2 . TRP C 1 101 ? -41.44400 -21.01200 -14.48400 1.000 24.89649 ? 101 TRP C CZ2 1 
ATOM   3061 C CZ3 . TRP C 1 101 ? -40.23000 -19.85100 -16.20800 1.000 22.91715 ? 101 TRP C CZ3 1 
ATOM   3062 C CH2 . TRP C 1 101 ? -41.30500 -19.94800 -15.33400 1.000 24.78434 ? 101 TRP C CH2 1 
ATOM   3063 N N   . VAL C 1 102 ? -35.88400 -25.31000 -18.33500 1.000 21.22517 ? 102 VAL C N   1 
ATOM   3064 C CA  . VAL C 1 102 ? -34.71200 -25.58700 -19.17200 1.000 21.01211 ? 102 VAL C CA  1 
ATOM   3065 C C   . VAL C 1 102 ? -34.79600 -24.74300 -20.44700 1.000 21.90089 ? 102 VAL C C   1 
ATOM   3066 O O   . VAL C 1 102 ? -35.69400 -24.95000 -21.26400 1.000 20.38804 ? 102 VAL C O   1 
ATOM   3067 C CB  . VAL C 1 102 ? -34.59800 -27.08500 -19.54300 1.000 21.34337 ? 102 VAL C CB  1 
ATOM   3068 C CG1 . VAL C 1 102 ? -33.34700 -27.34400 -20.36000 1.000 25.35555 ? 102 VAL C CG1 1 
ATOM   3069 C CG2 . VAL C 1 102 ? -34.61000 -27.99600 -18.30700 1.000 18.90469 ? 102 VAL C CG2 1 
ATOM   3070 N N   . PHE C 1 103 ? -33.84600 -23.81800 -20.63600 1.000 24.04663 ? 103 PHE C N   1 
ATOM   3071 C CA  . PHE C 1 103 ? -33.67800 -23.05100 -21.87500 1.000 22.08473 ? 103 PHE C CA  1 
ATOM   3072 C C   . PHE C 1 103 ? -32.33300 -23.39400 -22.51300 1.000 24.66333 ? 103 PHE C C   1 
ATOM   3073 O O   . PHE C 1 103 ? -31.30600 -23.43900 -21.82000 1.000 24.69718 ? 103 PHE C O   1 
ATOM   3074 C CB  . PHE C 1 103 ? -33.70900 -21.51700 -21.65200 1.000 21.28110 ? 103 PHE C CB  1 
ATOM   3075 C CG  . PHE C 1 103 ? -35.01900 -20.95800 -21.12600 1.000 19.22550 ? 103 PHE C CG  1 
ATOM   3076 C CD1 . PHE C 1 103 ? -36.14000 -21.76100 -20.94000 1.000 20.38179 ? 103 PHE C CD1 1 
ATOM   3077 C CD2 . PHE C 1 103 ? -35.12000 -19.60400 -20.83500 1.000 18.92012 ? 103 PHE C CD2 1 
ATOM   3078 C CE1 . PHE C 1 103 ? -37.33100 -21.23400 -20.45500 1.000 18.71818 ? 103 PHE C CE1 1 
ATOM   3079 C CE2 . PHE C 1 103 ? -36.31300 -19.06700 -20.37200 1.000 23.23011 ? 103 PHE C CE2 1 
ATOM   3080 C CZ  . PHE C 1 103 ? -37.42700 -19.89600 -20.17100 1.000 20.16378 ? 103 PHE C CZ  1 
ATOM   3081 N N   . PHE C 1 104 ? -32.32800 -23.60900 -23.83000 1.000 22.53926 ? 104 PHE C N   1 
ATOM   3082 C CA  . PHE C 1 104 ? -31.09300 -23.80900 -24.58500 1.000 22.13700 ? 104 PHE C CA  1 
ATOM   3083 C C   . PHE C 1 104 ? -30.80300 -22.57200 -25.42200 1.000 22.99043 ? 104 PHE C C   1 
ATOM   3084 O O   . PHE C 1 104 ? -31.65400 -22.13800 -26.21000 1.000 23.99891 ? 104 PHE C O   1 
ATOM   3085 C CB  . PHE C 1 104 ? -31.17100 -25.03500 -25.50700 1.000 23.00608 ? 104 PHE C CB  1 
ATOM   3086 C CG  . PHE C 1 104 ? -31.18600 -26.35300 -24.78000 1.000 22.41685 ? 104 PHE C CG  1 
ATOM   3087 C CD1 . PHE C 1 104 ? -30.79300 -26.43900 -23.44900 1.000 23.95948 ? 104 PHE C CD1 1 
ATOM   3088 C CD2 . PHE C 1 104 ? -31.59700 -27.51300 -25.43400 1.000 25.90631 ? 104 PHE C CD2 1 
ATOM   3089 C CE1 . PHE C 1 104 ? -30.81400 -27.64800 -22.77400 1.000 21.33804 ? 104 PHE C CE1 1 
ATOM   3090 C CE2 . PHE C 1 104 ? -31.61400 -28.72700 -24.76900 1.000 24.48640 ? 104 PHE C CE2 1 
ATOM   3091 C CZ  . PHE C 1 104 ? -31.22100 -28.79600 -23.43300 1.000 23.03846 ? 104 PHE C CZ  1 
ATOM   3092 N N   . GLY C 1 105 ? -29.60300 -22.01200 -25.27100 1.000 23.69166 ? 105 GLY C N   1 
ATOM   3093 C CA  . GLY C 1 105 ? -29.10400 -20.97700 -26.16800 1.000 23.00466 ? 105 GLY C CA  1 
ATOM   3094 C C   . GLY C 1 105 ? -28.00000 -21.54800 -27.04100 1.000 23.81122 ? 105 GLY C C   1 
ATOM   3095 O O   . GLY C 1 105 ? -27.27100 -22.46600 -26.62900 1.000 21.46103 ? 105 GLY C O   1 
ATOM   3096 N N   . GLU C 1 106 ? -27.86900 -21.00400 -28.25200 1.000 17.98829 ? 106 GLU C N   1 
ATOM   3097 C CA  . GLU C 1 106 ? -26.88800 -21.47400 -29.21900 1.000 24.79278 ? 106 GLU C CA  1 
ATOM   3098 C C   . GLU C 1 106 ? -26.05200 -20.31400 -29.73800 1.000 27.98437 ? 106 GLU C C   1 
ATOM   3099 O O   . GLU C 1 106 ? -26.52500 -19.18000 -29.85300 1.000 24.05956 ? 106 GLU C O   1 
ATOM   3100 C CB  . GLU C 1 106 ? -27.54600 -22.20200 -30.41700 1.000 24.07948 ? 106 GLU C CB  1 
ATOM   3101 C CG  . GLU C 1 106 ? -28.23200 -23.51500 -30.07200 1.000 24.83924 ? 106 GLU C CG  1 
ATOM   3102 C CD  . GLU C 1 106 ? -29.28600 -23.89700 -31.10800 1.000 27.03058 ? 106 GLU C CD  1 
ATOM   3103 O OE1 . GLU C 1 106 ? -30.41600 -23.37600 -31.00400 1.000 20.71234 ? 106 GLU C OE1 1 
ATOM   3104 O OE2 . GLU C 1 106 ? -28.99800 -24.73800 -32.00400 1.000 27.37509 ? 106 GLU C OE2 1 
ATOM   3105 N N   . MET C 1 107 ? -24.79800 -20.63000 -30.05500 1.000 26.28974 ? 107 MET C N   1 
ATOM   3106 C CA  . MET C 1 107 ? -23.77300 -19.71900 -30.55100 1.000 24.39873 ? 107 MET C CA  1 
ATOM   3107 C C   . MET C 1 107 ? -22.91200 -20.48500 -31.54200 1.000 26.88620 ? 107 MET C C   1 
ATOM   3108 O O   . MET C 1 107 ? -22.78400 -21.71100 -31.43300 1.000 24.25463 ? 107 MET C O   1 
ATOM   3109 C CB  . MET C 1 107 ? -22.88200 -19.18700 -29.41400 1.000 23.98276 ? 107 MET C CB  1 
ATOM   3110 C CG  . MET C 1 107 ? -23.68700 -18.53500 -28.30800 1.000 27.99843 ? 107 MET C CG  1 
ATOM   3111 S SD  . MET C 1 107 ? -22.90500 -18.64800 -26.69400 1.000 34.66682 ? 107 MET C SD  1 
ATOM   3112 C CE  . MET C 1 107 ? -23.42700 -20.32200 -26.26300 1.000 25.72214 ? 107 MET C CE  1 
ATOM   3113 N N   . PRO C 1 108 ? -22.34500 -19.80300 -32.53600 1.000 24.72336 ? 108 PRO C N   1 
ATOM   3114 C CA  . PRO C 1 108 ? -21.36400 -20.46200 -33.40600 1.000 23.86090 ? 108 PRO C CA  1 
ATOM   3115 C C   . PRO C 1 108 ? -20.17800 -20.97900 -32.60000 1.000 24.27685 ? 108 PRO C C   1 
ATOM   3116 O O   . PRO C 1 108 ? -19.65800 -20.28300 -31.72200 1.000 23.41497 ? 108 PRO C O   1 
ATOM   3117 C CB  . PRO C 1 108 ? -20.94100 -19.34600 -34.37000 1.000 26.48918 ? 108 PRO C CB  1 
ATOM   3118 C CG  . PRO C 1 108 ? -22.08700 -18.34700 -34.35500 1.000 22.77269 ? 108 PRO C CG  1 
ATOM   3119 C CD  . PRO C 1 108 ? -22.62200 -18.40800 -32.93600 1.000 26.29090 ? 108 PRO C CD  1 
ATOM   3120 N N   . ALA C 1 109 ? -19.74300 -22.21200 -32.91100 1.000 25.08922 ? 109 ALA C N   1 
ATOM   3121 C CA  . ALA C 1 109 ? -18.54000 -22.73900 -32.26500 1.000 27.82920 ? 109 ALA C CA  1 
ATOM   3122 C C   . ALA C 1 109 ? -17.34500 -21.80000 -32.43600 1.000 29.11719 ? 109 ALA C C   1 
ATOM   3123 O O   . ALA C 1 109 ? -16.47200 -21.74100 -31.56300 1.000 26.90782 ? 109 ALA C O   1 
ATOM   3124 C CB  . ALA C 1 109 ? -18.20300 -24.12500 -32.81400 1.000 26.27336 ? 109 ALA C CB  1 
ATOM   3125 N N   . GLN C 1 110 ? -17.31500 -21.03000 -33.53000 1.000 23.87170 ? 110 GLN C N   1 
ATOM   3126 C CA  . GLN C 1 110 ? -16.23100 -20.08900 -33.79900 1.000 27.87638 ? 110 GLN C CA  1 
ATOM   3127 C C   . GLN C 1 110 ? -16.08300 -19.02200 -32.73100 1.000 26.30990 ? 110 GLN C C   1 
ATOM   3128 O O   . GLN C 1 110 ? -15.05800 -18.32900 -32.70800 1.000 23.98841 ? 110 GLN C O   1 
ATOM   3129 C CB  . GLN C 1 110 ? -16.45200 -19.36900 -35.14000 1.000 33.03270 ? 110 GLN C CB  1 
ATOM   3130 C CG  . GLN C 1 110 ? -16.30300 -20.24100 -36.36800 1.000 38.95572 ? 110 GLN C CG  1 
ATOM   3131 C CD  . GLN C 1 110 ? -17.56400 -21.03200 -36.62500 1.000 44.24047 ? 110 GLN C CD  1 
ATOM   3132 O OE1 . GLN C 1 110 ? -18.65900 -20.57300 -36.32000 1.000 42.92228 ? 110 GLN C OE1 1 
ATOM   3133 N NE2 . GLN C 1 110 ? -17.42400 -22.21300 -37.20400 1.000 53.20350 ? 110 GLN C NE2 1 
ATOM   3134 N N   . GLN C 1 111 ? -17.09600 -18.80600 -31.89900 1.000 24.98040 ? 111 GLN C N   1 
ATOM   3135 C CA  . GLN C 1 111 ? -16.97400 -17.83400 -30.81800 1.000 26.57866 ? 111 GLN C CA  1 
ATOM   3136 C C   . GLN C 1 111 ? -17.17500 -18.51600 -29.47400 1.000 24.92194 ? 111 GLN C C   1 
ATOM   3137 O O   . GLN C 1 111 ? -17.68400 -17.90900 -28.52700 1.000 22.04346 ? 111 GLN C O   1 
ATOM   3138 C CB  . GLN C 1 111 ? -17.95000 -16.66100 -30.99700 1.000 21.07884 ? 111 GLN C CB  1 
ATOM   3139 C CG  . GLN C 1 111 ? -19.42300 -17.01700 -30.97200 1.000 23.54820 ? 111 GLN C CG  1 
ATOM   3140 C CD  . GLN C 1 111 ? -20.30000 -15.94800 -31.64300 1.000 28.79739 ? 111 GLN C CD  1 
ATOM   3141 O OE1 . GLN C 1 111 ? -20.08200 -15.58800 -32.80500 1.000 25.75516 ? 111 GLN C OE1 1 
ATOM   3142 N NE2 . GLN C 1 111 ? -21.30300 -15.45300 -30.91800 1.000 20.54713 ? 111 GLN C NE2 1 
ATOM   3143 N N   . MET C 1 112 ? -16.77100 -19.78400 -29.37600 1.000 26.17422 ? 112 MET C N   1 
ATOM   3144 C CA  . MET C 1 112 ? -16.81600 -20.50100 -28.11100 1.000 22.92182 ? 112 MET C CA  1 
ATOM   3145 C C   . MET C 1 112 ? -15.46900 -21.14400 -27.80900 1.000 28.12585 ? 112 MET C C   1 
ATOM   3146 O O   . MET C 1 112 ? -14.90700 -21.86000 -28.64800 1.000 28.31880 ? 112 MET C O   1 
ATOM   3147 C CB  . MET C 1 112 ? -17.91300 -21.55400 -28.10100 1.000 21.50131 ? 112 MET C CB  1 
ATOM   3148 C CG  . MET C 1 112 ? -19.31200 -20.96500 -28.08300 1.000 26.80783 ? 112 MET C CG  1 
ATOM   3149 S SD  . MET C 1 112 ? -20.52000 -22.15300 -28.63600 1.000 23.99415 ? 112 MET C SD  1 
ATOM   3150 C CE  . MET C 1 112 ? -20.64200 -23.03500 -27.04700 1.000 23.61541 ? 112 MET C CE  1 
ATOM   3151 N N   . VAL C 1 113 ? -14.97400 -20.90000 -26.59600 1.000 28.19008 ? 113 VAL C N   1 
ATOM   3152 C CA  . VAL C 1 113 ? -13.66600 -21.35300 -26.15600 1.000 25.11252 ? 113 VAL C CA  1 
ATOM   3153 C C   . VAL C 1 113 ? -13.85700 -22.15600 -24.88100 1.000 30.69501 ? 113 VAL C C   1 
ATOM   3154 O O   . VAL C 1 113 ? -14.51100 -21.69100 -23.93500 1.000 25.79273 ? 113 VAL C O   1 
ATOM   3155 C CB  . VAL C 1 113 ? -12.71000 -20.16600 -25.93400 1.000 31.07420 ? 113 VAL C CB  1 
ATOM   3156 C CG1 . VAL C 1 113 ? -11.52600 -20.57800 -25.06100 1.000 27.17564 ? 113 VAL C CG1 1 
ATOM   3157 C CG2 . VAL C 1 113 ? -12.24500 -19.61200 -27.27200 1.000 24.23788 ? 113 VAL C CG2 1 
ATOM   3158 N N   . GLU C 1 114 ? -13.34000 -23.38400 -24.88800 1.000 26.61852 ? 114 GLU C N   1 
ATOM   3159 C CA  . GLU C 1 114 ? -13.24800 -24.23000 -23.71200 1.000 25.91192 ? 114 GLU C CA  1 
ATOM   3160 C C   . GLU C 1 114 ? -11.81200 -24.70500 -23.57200 1.000 29.61989 ? 114 GLU C C   1 
ATOM   3161 O O   . GLU C 1 114 ? -11.16200 -25.02400 -24.57300 1.000 31.04396 ? 114 GLU C O   1 
ATOM   3162 C CB  . GLU C 1 114 ? -14.17800 -25.42800 -23.82000 1.000 28.15418 ? 114 GLU C CB  1 
ATOM   3163 C CG  . GLU C 1 114 ? -15.57200 -25.03300 -24.23900 1.000 27.53050 ? 114 GLU C CG  1 
ATOM   3164 C CD  . GLU C 1 114 ? -16.56100 -26.12500 -24.02400 1.000 31.18843 ? 114 GLU C CD  1 
ATOM   3165 O OE1 . GLU C 1 114 ? -16.13800 -27.27600 -23.78000 1.000 32.64699 ? 114 GLU C OE1 1 
ATOM   3166 O OE2 . GLU C 1 114 ? -17.76700 -25.81600 -24.02100 1.000 30.73484 ? 114 GLU C OE2 1 
ATOM   3167 N N   . TYR C 1 115 ? -11.32500 -24.77100 -22.33200 1.000 27.58066 ? 115 TYR C N   1 
ATOM   3168 C CA  . TYR C 1 115 ? -9.94200  -25.15200 -22.07400 1.000 29.48611 ? 115 TYR C CA  1 
ATOM   3169 C C   . TYR C 1 115 ? -8.99400  -24.28000 -22.89100 1.000 31.81271 ? 115 TYR C C   1 
ATOM   3170 O O   . TYR C 1 115 ? -7.99200  -24.75400 -23.42500 1.000 28.52826 ? 115 TYR C O   1 
ATOM   3171 C CB  . TYR C 1 115 ? -9.69500  -26.63900 -22.38000 1.000 28.38230 ? 115 TYR C CB  1 
ATOM   3172 C CG  . TYR C 1 115 ? -10.50500 -27.63000 -21.55700 1.000 32.46101 ? 115 TYR C CG  1 
ATOM   3173 C CD1 . TYR C 1 115 ? -10.08100 -28.02000 -20.28400 1.000 30.26992 ? 115 TYR C CD1 1 
ATOM   3174 C CD2 . TYR C 1 115 ? -11.67600 -28.20000 -22.06200 1.000 29.76181 ? 115 TYR C CD2 1 
ATOM   3175 C CE1 . TYR C 1 115 ? -10.80800 -28.92400 -19.53500 1.000 31.54862 ? 115 TYR C CE1 1 
ATOM   3176 C CE2 . TYR C 1 115 ? -12.40600 -29.11100 -21.31800 1.000 30.25721 ? 115 TYR C CE2 1 
ATOM   3177 C CZ  . TYR C 1 115 ? -11.96000 -29.46100 -20.05600 1.000 33.71693 ? 115 TYR C CZ  1 
ATOM   3178 O OH  . TYR C 1 115 ? -12.66500 -30.35900 -19.30600 1.000 36.39541 ? 115 TYR C OH  1 
ATOM   3179 N N   . GLY C 1 116 ? -9.34400  -23.00100 -23.03300 1.000 29.61322 ? 116 GLY C N   1 
ATOM   3180 C CA  . GLY C 1 116 ? -8.51600  -22.08500 -23.80100 1.000 29.75442 ? 116 GLY C CA  1 
ATOM   3181 C C   . GLY C 1 116 ? -8.45500  -22.34100 -25.29000 1.000 32.86307 ? 116 GLY C C   1 
ATOM   3182 O O   . GLY C 1 116 ? -7.63500  -21.70900 -25.96900 1.000 32.74989 ? 116 GLY C O   1 
ATOM   3183 N N   . ARG C 1 117 ? -9.31000  -23.23500 -25.82800 1.000 34.20375 ? 117 ARG C N   1 
ATOM   3184 C CA  . ARG C 1 117 ? -9.28300  -23.62700 -27.24000 1.000 35.19050 ? 117 ARG C CA  1 
ATOM   3185 C C   . ARG C 1 117 ? -10.65300 -23.47300 -27.89900 1.000 31.40738 ? 117 ARG C C   1 
ATOM   3186 O O   . ARG C 1 117 ? -11.68500 -23.74900 -27.27900 1.000 27.46340 ? 117 ARG C O   1 
ATOM   3187 C CB  . ARG C 1 117 ? -8.80900  -25.08100 -27.39900 1.000 35.77170 ? 117 ARG C CB  1 
ATOM   3188 C CG  . ARG C 1 117 ? -7.30300  -25.23400 -27.33900 1.000 44.60222 ? 117 ARG C CG  1 
ATOM   3189 C CD  . ARG C 1 117 ? -6.57300  -24.21900 -28.24700 1.000 47.22984 ? 117 ARG C CD  1 
ATOM   3190 N NE  . ARG C 1 117 ? -5.20700  -24.65400 -28.51300 1.000 52.86864 ? 117 ARG C NE  1 
ATOM   3191 C CZ  . ARG C 1 117 ? -4.88700  -25.64100 -29.33800 1.000 56.51887 ? 117 ARG C CZ  1 
ATOM   3192 N NH1 . ARG C 1 117 ? -5.80700  -26.26800 -30.05200 1.000 55.02086 ? 117 ARG C NH1 1 
ATOM   3193 N NH2 . ARG C 1 117 ? -3.61300  -26.00800 -29.45000 1.000 54.30907 ? 117 ARG C NH2 1 
ATOM   3194 N N   . PHE C 1 118 ? -10.65500 -23.06500 -29.16900 1.000 32.54020 ? 118 PHE C N   1 
ATOM   3195 C CA  . PHE C 1 118 ? -11.90700 -22.85200 -29.89300 1.000 30.52922 ? 118 PHE C CA  1 
ATOM   3196 C C   . PHE C 1 118 ? -12.57100 -24.18400 -30.20900 1.000 30.32394 ? 118 PHE C C   1 
ATOM   3197 O O   . PHE C 1 118 ? -11.91400 -25.15800 -30.59800 1.000 27.50308 ? 118 PHE C O   1 
ATOM   3198 C CB  . PHE C 1 118 ? -11.67100 -22.05300 -31.18400 1.000 26.43509 ? 118 PHE C CB  1 
ATOM   3199 C CG  . PHE C 1 118 ? -11.42200 -20.59100 -30.93600 1.000 27.43821 ? 118 PHE C CG  1 
ATOM   3200 C CD1 . PHE C 1 118 ? -10.14200 -20.14000 -30.64600 1.000 31.02160 ? 118 PHE C CD1 1 
ATOM   3201 C CD2 . PHE C 1 118 ? -12.46800 -19.68200 -30.93000 1.000 26.40951 ? 118 PHE C CD2 1 
ATOM   3202 C CE1 . PHE C 1 118 ? -9.89900  -18.80400 -30.38100 1.000 31.77820 ? 118 PHE C CE1 1 
ATOM   3203 C CE2 . PHE C 1 118 ? -12.24400 -18.33300 -30.67900 1.000 27.36922 ? 118 PHE C CE2 1 
ATOM   3204 C CZ  . PHE C 1 118 ? -10.95900 -17.88900 -30.39900 1.000 32.05484 ? 118 PHE C CZ  1 
ATOM   3205 N N   . LEU C 1 119 ? -13.86000 -24.22600 -30.01700 1.000 24.85225 ? 119 LEU C N   1 
ATOM   3206 C CA  . LEU C 1 119 ? -14.57400 -25.47300 -30.18700 1.000 29.88101 ? 119 LEU C CA  1 
ATOM   3207 C C   . LEU C 1 119 ? -14.70600 -25.80300 -31.66700 1.000 30.70381 ? 119 LEU C C   1 
ATOM   3208 O O   . LEU C 1 119 ? -14.77400 -24.90200 -32.50400 1.000 30.12214 ? 119 LEU C O   1 
ATOM   3209 C CB  . LEU C 1 119 ? -15.95800 -25.39000 -29.53900 1.000 28.11272 ? 119 LEU C CB  1 
ATOM   3210 C CG  . LEU C 1 119 ? -15.94400 -25.37100 -28.00700 1.000 24.50048 ? 119 LEU C CG  1 
ATOM   3211 C CD1 . LEU C 1 119 ? -17.37700 -25.44200 -27.44400 1.000 23.38516 ? 119 LEU C CD1 1 
ATOM   3212 C CD2 . LEU C 1 119 ? -15.06500 -26.50400 -27.44000 1.000 28.88253 ? 119 LEU C CD2 1 
ATOM   3213 N N   . PRO C 1 120 ? -14.73100 -27.08400 -32.00600 1.000 28.16626 ? 120 PRO C N   1 
ATOM   3214 C CA  . PRO C 1 120 ? -15.06900 -27.49100 -33.37000 1.000 32.53257 ? 120 PRO C CA  1 
ATOM   3215 C C   . PRO C 1 120 ? -16.58100 -27.50300 -33.56900 1.000 29.95420 ? 120 PRO C C   1 
ATOM   3216 O O   . PRO C 1 120 ? -17.37400 -27.37200 -32.63100 1.000 29.40415 ? 120 PRO C O   1 
ATOM   3217 C CB  . PRO C 1 120 ? -14.54500 -28.91900 -33.44300 1.000 35.49807 ? 120 PRO C CB  1 
ATOM   3218 C CG  . PRO C 1 120 ? -14.42900 -29.37100 -32.01400 1.000 35.19565 ? 120 PRO C CG  1 
ATOM   3219 C CD  . PRO C 1 120 ? -14.74400 -28.23700 -31.09100 1.000 32.30737 ? 120 PRO C CD  1 
ATOM   3220 N N   . GLN C 1 121 ? -16.97100 -27.71100 -34.82100 1.000 27.58636 ? 121 GLN C N   1 
ATOM   3221 C CA  . GLN C 1 121 ? -18.36600 -27.91500 -35.13500 1.000 30.94025 ? 121 GLN C CA  1 
ATOM   3222 C C   . GLN C 1 121 ? -18.85200 -29.25200 -34.57000 1.000 34.51030 ? 121 GLN C C   1 
ATOM   3223 O O   . GLN C 1 121 ? -18.06900 -30.19300 -34.44600 1.000 33.17707 ? 121 GLN C O   1 
ATOM   3224 C CB  . GLN C 1 121 ? -18.56300 -27.85000 -36.64500 1.000 32.40128 ? 121 GLN C CB  1 
ATOM   3225 C CG  . GLN C 1 121 ? -18.42800 -26.43200 -37.17800 1.000 34.12580 ? 121 GLN C CG  1 
ATOM   3226 C CD  . GLN C 1 121 ? -19.72500 -25.64600 -37.02100 1.000 43.63927 ? 121 GLN C CD  1 
ATOM   3227 O OE1 . GLN C 1 121 ? -19.73200 -24.51500 -36.52200 1.000 39.71119 ? 121 GLN C OE1 1 
ATOM   3228 N NE2 . GLN C 1 121 ? -20.84200 -26.26400 -37.42500 1.000 45.54159 ? 121 GLN C NE2 1 
ATOM   3229 N N   . PRO C 1 122 ? -20.15500 -29.34300 -34.19500 1.000 35.11467 ? 122 PRO C N   1 
ATOM   3230 C CA  . PRO C 1 122 ? -20.66500 -30.50300 -33.44300 1.000 38.08065 ? 122 PRO C CA  1 
ATOM   3231 C C   . PRO C 1 122 ? -20.39800 -31.93600 -33.92800 1.000 44.71464 ? 122 PRO C C   1 
ATOM   3232 O O   . PRO C 1 122 ? -20.67500 -32.86400 -33.16300 1.000 52.52984 ? 122 PRO C O   1 
ATOM   3233 C CB  . PRO C 1 122 ? -22.16800 -30.23800 -33.42100 1.000 36.28972 ? 122 PRO C CB  1 
ATOM   3234 C CG  . PRO C 1 122 ? -22.29800 -28.74800 -33.48900 1.000 33.29792 ? 122 PRO C CG  1 
ATOM   3235 C CD  . PRO C 1 122 ? -21.02300 -28.16900 -34.04500 1.000 31.40040 ? 122 PRO C CD  1 
ATOM   3236 N N   . GLY C 1 123 ? -19.89700 -32.19100 -35.12600 1.000 43.27237 ? 123 GLY C N   1 
ATOM   3237 C CA  . GLY C 1 123 ? -19.59100 -33.58400 -35.41100 1.000 44.32212 ? 123 GLY C CA  1 
ATOM   3238 C C   . GLY C 1 123 ? -18.11300 -33.92600 -35.38300 1.000 43.88964 ? 123 GLY C C   1 
ATOM   3239 O O   . GLY C 1 123 ? -17.74000 -35.09800 -35.42200 1.000 38.54301 ? 123 GLY C O   1 
ATOM   3240 N N   . HIS C 1 124 ? -17.28000 -32.89400 -35.26000 1.000 43.90243 ? 124 HIS C N   1 
ATOM   3241 C CA  . HIS C 1 124 ? -15.85500 -32.88000 -35.58100 1.000 46.35357 ? 124 HIS C CA  1 
ATOM   3242 C C   . HIS C 1 124 ? -14.98200 -33.02700 -34.33100 1.000 44.60194 ? 124 HIS C C   1 
ATOM   3243 O O   . HIS C 1 124 ? -13.75500 -33.01500 -34.43300 1.000 45.99568 ? 124 HIS C O   1 
ATOM   3244 C CB  . HIS C 1 124 ? -15.58600 -31.57300 -36.38700 1.000 47.18547 ? 124 HIS C CB  1 
ATOM   3245 C CG  . HIS C 1 124 ? -14.14100 -31.19000 -36.64000 1.000 65.48859 ? 124 HIS C CG  1 
ATOM   3246 N ND1 . HIS C 1 124 ? -13.64000 -31.03700 -37.92300 1.000 73.71786 ? 124 HIS C ND1 1 
ATOM   3247 C CD2 . HIS C 1 124 ? -13.15000 -30.77300 -35.80600 1.000 58.72539 ? 124 HIS C CD2 1 
ATOM   3248 C CE1 . HIS C 1 124 ? -12.38400 -30.62700 -37.86200 1.000 68.55864 ? 124 HIS C CE1 1 
ATOM   3249 N NE2 . HIS C 1 124 ? -12.06200 -30.46300 -36.58800 1.000 59.24444 ? 124 HIS C NE2 1 
ATOM   3250 N N   . GLU C 1 125 ? -15.58100 -33.25300 -33.15800 1.000 40.55558 ? 125 GLU C N   1 
ATOM   3251 C CA  . GLU C 1 125 ? -14.80500 -33.19300 -31.91800 1.000 46.01669 ? 125 GLU C CA  1 
ATOM   3252 C C   . GLU C 1 125 ? -13.74400 -34.29400 -31.81900 1.000 44.77147 ? 125 GLU C C   1 
ATOM   3253 O O   . GLU C 1 125 ? -12.80900 -34.16300 -31.02300 1.000 36.93293 ? 125 GLU C O   1 
ATOM   3254 C CB  . GLU C 1 125 ? -15.73900 -33.23100 -30.70200 1.000 46.84676 ? 125 GLU C CB  1 
ATOM   3255 C CG  . GLU C 1 125 ? -16.85100 -34.26500 -30.74600 1.000 51.59213 ? 125 GLU C CG  1 
ATOM   3256 C CD  . GLU C 1 125 ? -18.14500 -33.74600 -31.38100 1.000 42.00461 ? 125 GLU C CD  1 
ATOM   3257 O OE1 . GLU C 1 125 ? -18.69700 -32.70400 -30.93700 1.000 42.93538 ? 125 GLU C OE1 1 
ATOM   3258 O OE2 . GLU C 1 125 ? -18.62600 -34.41400 -32.31900 1.000 47.01234 ? 125 GLU C OE2 1 
ATOM   3259 N N   . GLY C 1 126 ? -13.84200 -35.34300 -32.64100 1.000 44.28683 ? 126 GLY C N   1 
ATOM   3260 C CA  . GLY C 1 126 ? -12.85500 -36.41600 -32.59700 1.000 47.00778 ? 126 GLY C CA  1 
ATOM   3261 C C   . GLY C 1 126 ? -11.49500 -35.99800 -33.13300 1.000 45.57298 ? 126 GLY C C   1 
ATOM   3262 O O   . GLY C 1 126 ? -10.47300 -36.14700 -32.45300 1.000 46.29584 ? 126 GLY C O   1 
ATOM   3263 N N   . GLU C 1 127 ? -11.46000 -35.47700 -34.36300 1.000 43.95452 ? 127 GLU C N   1 
ATOM   3264 C CA  . GLU C 1 127 ? -10.19700 -34.99300 -34.90700 1.000 46.77969 ? 127 GLU C CA  1 
ATOM   3265 C C   . GLU C 1 127 ? -9.67200  -33.81200 -34.10100 1.000 46.28351 ? 127 GLU C C   1 
ATOM   3266 O O   . GLU C 1 127 ? -8.46200  -33.71800 -33.84800 1.000 49.54722 ? 127 GLU C O   1 
ATOM   3267 C CB  . GLU C 1 127 ? -10.36300 -34.61600 -36.37700 1.000 51.99669 ? 127 GLU C CB  1 
ATOM   3268 C CG  . GLU C 1 127 ? -11.43100 -33.56600 -36.64700 1.000 57.43342 ? 127 GLU C CG  1 
ATOM   3269 C CD  . GLU C 1 127 ? -12.60400 -34.06500 -37.49500 1.000 62.49113 ? 127 GLU C CD  1 
ATOM   3270 O OE1 . GLU C 1 127 ? -13.47800 -34.78200 -36.94200 1.000 59.90926 ? 127 GLU C OE1 1 
ATOM   3271 O OE2 . GLU C 1 127 ? -12.66800 -33.70800 -38.70100 1.000 60.84773 ? 127 GLU C OE2 1 
ATOM   3272 N N   . TRP C 1 128 ? -10.57300 -32.90400 -33.69400 1.000 43.19729 ? 128 TRP C N   1 
ATOM   3273 C CA  . TRP C 1 128 ? -10.20200 -31.74400 -32.88600 1.000 37.55762 ? 128 TRP C CA  1 
ATOM   3274 C C   . TRP C 1 128 ? -9.35500  -32.14700 -31.68500 1.000 37.80540 ? 128 TRP C C   1 
ATOM   3275 O O   . TRP C 1 128 ? -8.29700  -31.56000 -31.42800 1.000 39.03842 ? 128 TRP C O   1 
ATOM   3276 C CB  . TRP C 1 128 ? -11.47600 -31.03600 -32.42800 1.000 38.02358 ? 128 TRP C CB  1 
ATOM   3277 C CG  . TRP C 1 128 ? -11.33700 -29.85100 -31.48500 1.000 34.67292 ? 128 TRP C CG  1 
ATOM   3278 C CD1 . TRP C 1 128 ? -11.21700 -28.53200 -31.83000 1.000 31.82953 ? 128 TRP C CD1 1 
ATOM   3279 C CD2 . TRP C 1 128 ? -11.38900 -29.88400 -30.05800 1.000 32.16323 ? 128 TRP C CD2 1 
ATOM   3280 N NE1 . TRP C 1 128 ? -11.17100 -27.75000 -30.70100 1.000 30.94477 ? 128 TRP C NE1 1 
ATOM   3281 C CE2 . TRP C 1 128 ? -11.26600 -28.55700 -29.60100 1.000 33.04875 ? 128 TRP C CE2 1 
ATOM   3282 C CE3 . TRP C 1 128 ? -11.50600 -30.91000 -29.12000 1.000 36.30851 ? 128 TRP C CE3 1 
ATOM   3283 C CZ2 . TRP C 1 128 ? -11.25200 -28.23100 -28.23700 1.000 36.73500 ? 128 TRP C CZ2 1 
ATOM   3284 C CZ3 . TRP C 1 128 ? -11.49600 -30.58600 -27.76700 1.000 34.51113 ? 128 TRP C CZ3 1 
ATOM   3285 C CH2 . TRP C 1 128 ? -11.37300 -29.25900 -27.33900 1.000 35.04628 ? 128 TRP C CH2 1 
ATOM   3286 N N   . PHE C 1 129 ? -9.81700  -33.16100 -30.94500 1.000 36.56959 ? 129 PHE C N   1 
ATOM   3287 C CA  . PHE C 1 129 ? -9.10300  -33.63500 -29.76500 1.000 44.98454 ? 129 PHE C CA  1 
ATOM   3288 C C   . PHE C 1 129 ? -7.65900  -34.03000 -30.09200 1.000 48.71325 ? 129 PHE C C   1 
ATOM   3289 O O   . PHE C 1 129 ? -6.76700  -33.82800 -29.26300 1.000 50.30240 ? 129 PHE C O   1 
ATOM   3290 C CB  . PHE C 1 129 ? -9.88500  -34.79900 -29.14600 1.000 38.85396 ? 129 PHE C CB  1 
ATOM   3291 C CG  . PHE C 1 129 ? -9.33700  -35.28200 -27.83400 1.000 47.42925 ? 129 PHE C CG  1 
ATOM   3292 C CD1 . PHE C 1 129 ? -9.32100  -34.44100 -26.72900 1.000 45.06527 ? 129 PHE C CD1 1 
ATOM   3293 C CD2 . PHE C 1 129 ? -8.86600  -36.58100 -27.68800 1.000 48.42041 ? 129 PHE C CD2 1 
ATOM   3294 C CE1 . PHE C 1 129 ? -8.82100  -34.86900 -25.51200 1.000 41.86199 ? 129 PHE C CE1 1 
ATOM   3295 C CE2 . PHE C 1 129 ? -8.37900  -37.02500 -26.46200 1.000 47.25523 ? 129 PHE C CE2 1 
ATOM   3296 C CZ  . PHE C 1 129 ? -8.35500  -36.16000 -25.37400 1.000 46.12562 ? 129 PHE C CZ  1 
ATOM   3297 N N   . ASP C 1 130 ? -7.38900  -34.50000 -31.32200 1.000 52.27111 ? 130 ASP C N   1 
ATOM   3298 C CA  . ASP C 1 130 ? -6.10300  -35.12500 -31.61400 1.000 55.02708 ? 130 ASP C CA  1 
ATOM   3299 C C   . ASP C 1 130 ? -4.97300  -34.14300 -31.92800 1.000 59.20129 ? 130 ASP C C   1 
ATOM   3300 O O   . ASP C 1 130 ? -3.80700  -34.48700 -31.69400 1.000 64.70138 ? 130 ASP C O   1 
ATOM   3301 C CB  . ASP C 1 130 ? -6.25400  -36.12700 -32.75700 1.000 55.38603 ? 130 ASP C CB  1 
ATOM   3302 C CG  . ASP C 1 130 ? -6.94500  -37.41200 -32.31800 1.000 60.62572 ? 130 ASP C CG  1 
ATOM   3303 O OD1 . ASP C 1 130 ? -6.48000  -38.02800 -31.33200 1.000 69.02994 ? 130 ASP C OD1 1 
ATOM   3304 O OD2 . ASP C 1 130 ? -7.93900  -37.82300 -32.96100 1.000 49.05449 ? 130 ASP C OD2 1 
ATOM   3305 N N   . ASN C 1 131 ? -5.25900  -32.94600 -32.44100 1.000 57.48224 ? 131 ASN C N   1 
ATOM   3306 C CA  . ASN C 1 131 ? -4.19900  -31.96200 -32.63500 1.000 62.54246 ? 131 ASN C CA  1 
ATOM   3307 C C   . ASN C 1 131 ? -4.07400  -30.98200 -31.47900 1.000 59.11916 ? 131 ASN C C   1 
ATOM   3308 O O   . ASN C 1 131 ? -3.31900  -30.00700 -31.57900 1.000 64.54958 ? 131 ASN C O   1 
ATOM   3309 C CB  . ASN C 1 131 ? -4.38400  -31.22000 -33.95400 1.000 73.98361 ? 131 ASN C CB  1 
ATOM   3310 C CG  . ASN C 1 131 ? -3.62600  -31.88200 -35.09400 1.000 77.52190 ? 131 ASN C CG  1 
ATOM   3311 O OD1 . ASN C 1 131 ? -4.22500  -32.45800 -36.00200 1.000 75.33106 ? 131 ASN C OD1 1 
ATOM   3312 N ND2 . ASN C 1 131 ? -2.29100  -31.82500 -35.03100 1.000 80.46636 ? 131 ASN C ND2 1 
ATOM   3313 N N   . LEU C 1 132 ? -4.79200  -31.21800 -30.38800 1.000 56.00973 ? 132 LEU C N   1 
ATOM   3314 C CA  . LEU C 1 132 ? -4.43100  -30.59000 -29.12900 1.000 55.54659 ? 132 LEU C CA  1 
ATOM   3315 C C   . LEU C 1 132 ? -3.07100  -31.10700 -28.68400 1.000 53.13796 ? 132 LEU C C   1 
ATOM   3316 O O   . LEU C 1 132 ? -2.76100  -32.28900 -28.85000 1.000 55.69929 ? 132 LEU C O   1 
ATOM   3317 C CB  . LEU C 1 132 ? -5.48300  -30.89000 -28.06700 1.000 50.18824 ? 132 LEU C CB  1 
ATOM   3318 C CG  . LEU C 1 132 ? -6.91900  -30.59300 -28.47100 1.000 45.00644 ? 132 LEU C CG  1 
ATOM   3319 C CD1 . LEU C 1 132 ? -7.84500  -31.01600 -27.35900 1.000 44.61115 ? 132 LEU C CD1 1 
ATOM   3320 C CD2 . LEU C 1 132 ? -7.11000  -29.11600 -28.80300 1.000 45.99557 ? 132 LEU C CD2 1 
ATOM   3321 N N   . SER C 1 133 ? -2.25100  -30.21600 -28.13300 1.000 48.30132 ? 133 SER C N   1 
ATOM   3322 C CA  . SER C 1 133 ? -0.98200  -30.65400 -27.58000 1.000 48.03410 ? 133 SER C CA  1 
ATOM   3323 C C   . SER C 1 133 ? -1.22000  -31.70800 -26.50000 1.000 51.50719 ? 133 SER C C   1 
ATOM   3324 O O   . SER C 1 133 ? -2.24000  -31.68700 -25.80300 1.000 49.88119 ? 133 SER C O   1 
ATOM   3325 C CB  . SER C 1 133 ? -0.19400  -29.45400 -27.03200 1.000 48.80043 ? 133 SER C CB  1 
ATOM   3326 O OG  . SER C 1 133 ? -0.51100  -29.15800 -25.68600 1.000 45.47504 ? 133 SER C OG  1 
ATOM   3327 N N   . SER C 1 134 ? -0.30600  -32.68500 -26.44400 1.000 53.82158 ? 134 SER C N   1 
ATOM   3328 C CA  . SER C 1 134 ? -0.11400  -33.64300 -25.35200 1.000 47.77016 ? 134 SER C CA  1 
ATOM   3329 C C   . SER C 1 134 ? -0.75700  -33.24800 -24.02900 1.000 41.04883 ? 134 SER C C   1 
ATOM   3330 O O   . SER C 1 134 ? -1.66900  -33.92800 -23.53600 1.000 38.57884 ? 134 SER C O   1 
ATOM   3331 C CB  . SER C 1 134 ? 1.38900   -33.82400 -25.10800 1.000 47.06618 ? 134 SER C CB  1 
ATOM   3332 O OG  . SER C 1 134 ? 1.90100   -34.91300 -25.82900 1.000 47.12756 ? 134 SER C OG  1 
ATOM   3333 N N   . ASP C 1 135 ? -0.25000  -32.15300 -23.45100 1.000 36.01120 ? 135 ASP C N   1 
ATOM   3334 C CA  . ASP C 1 135 ? -0.71000  -31.70900 -22.14000 1.000 38.92904 ? 135 ASP C CA  1 
ATOM   3335 C C   . ASP C 1 135 ? -2.20000  -31.41100 -22.14700 1.000 36.08038 ? 135 ASP C C   1 
ATOM   3336 O O   . ASP C 1 135 ? -2.91700  -31.77400 -21.20600 1.000 40.43849 ? 135 ASP C O   1 
ATOM   3337 C CB  . ASP C 1 135 ? 0.07500   -30.47400 -21.70200 1.000 39.84494 ? 135 ASP C CB  1 
ATOM   3338 C CG  . ASP C 1 135 ? 1.50800   -30.80400 -21.34500 1.000 49.60469 ? 135 ASP C CG  1 
ATOM   3339 O OD1 . ASP C 1 135 ? 2.07100   -31.73600 -21.95900 1.000 42.42183 ? 135 ASP C OD1 1 
ATOM   3340 O OD2 . ASP C 1 135 ? 2.06300   -30.11400 -20.44500 1.000 58.59021 ? 135 ASP C OD2 1 
ATOM   3341 N N   . GLU C 1 136 ? -2.68100  -30.73800 -23.19800 1.000 36.59674 ? 136 GLU C N   1 
ATOM   3342 C CA  . GLU C 1 136 ? -4.09900  -30.40900 -23.29200 1.000 40.55249 ? 136 GLU C CA  1 
ATOM   3343 C C   . GLU C 1 136 ? -4.94100  -31.66900 -23.29200 1.000 40.62650 ? 136 GLU C C   1 
ATOM   3344 O O   . GLU C 1 136 ? -5.97800  -31.73900 -22.61800 1.000 37.80497 ? 136 GLU C O   1 
ATOM   3345 C CB  . GLU C 1 136 ? -4.36500  -29.59800 -24.55700 1.000 38.96176 ? 136 GLU C CB  1 
ATOM   3346 C CG  . GLU C 1 136 ? -4.02500  -28.14200 -24.40500 1.000 39.03658 ? 136 GLU C CG  1 
ATOM   3347 C CD  . GLU C 1 136 ? -4.04300  -27.40100 -25.71500 1.000 43.59025 ? 136 GLU C CD  1 
ATOM   3348 O OE1 . GLU C 1 136 ? -3.62300  -27.98000 -26.72500 1.000 43.52668 ? 136 GLU C OE1 1 
ATOM   3349 O OE2 . GLU C 1 136 ? -4.49500  -26.24300 -25.73600 1.000 44.73316 ? 136 GLU C OE2 1 
ATOM   3350 N N   . ARG C 1 137 ? -4.49200  -32.68300 -24.03300 1.000 40.32208 ? 137 ARG C N   1 
ATOM   3351 C CA  . ARG C 1 137 ? -5.19900  -33.95300 -24.06400 1.000 39.83303 ? 137 ARG C CA  1 
ATOM   3352 C C   . ARG C 1 137 ? -5.15800  -34.62700 -22.70100 1.000 40.57717 ? 137 ARG C C   1 
ATOM   3353 O O   . ARG C 1 137 ? -6.19900  -35.04100 -22.17200 1.000 35.78194 ? 137 ARG C O   1 
ATOM   3354 C CB  . ARG C 1 137 ? -4.59600  -34.84700 -25.14100 1.000 43.42939 ? 137 ARG C CB  1 
ATOM   3355 C CG  . ARG C 1 137 ? -5.44800  -34.87300 -26.38400 1.000 47.98152 ? 137 ARG C CG  1 
ATOM   3356 C CD  . ARG C 1 137 ? -5.19400  -36.09000 -27.25300 1.000 54.62775 ? 137 ARG C CD  1 
ATOM   3357 N NE  . ARG C 1 137 ? -3.76500  -36.35700 -27.40500 1.000 53.69832 ? 137 ARG C NE  1 
ATOM   3358 C CZ  . ARG C 1 137 ? -2.99100  -35.86100 -28.35900 1.000 47.07764 ? 137 ARG C CZ  1 
ATOM   3359 N NH1 . ARG C 1 137 ? -3.47200  -35.06200 -29.29400 1.000 54.19325 ? 137 ARG C NH1 1 
ATOM   3360 N NH2 . ARG C 1 137 ? -1.70400  -36.18400 -28.37600 1.000 43.48673 ? 137 ARG C NH2 1 
ATOM   3361 N N   . ALA C 1 138 ? -3.96500  -34.70300 -22.09900 1.000 39.56853 ? 138 ALA C N   1 
ATOM   3362 C CA  . ALA C 1 138 ? -3.83600  -35.27800 -20.76200 1.000 37.83333 ? 138 ALA C CA  1 
ATOM   3363 C C   . ALA C 1 138 ? -4.72000  -34.55100 -19.74400 1.000 41.53151 ? 138 ALA C C   1 
ATOM   3364 O O   . ALA C 1 138 ? -5.35000  -35.19300 -18.89400 1.000 41.59017 ? 138 ALA C O   1 
ATOM   3365 C CB  . ALA C 1 138 ? -2.36700  -35.25500 -20.33000 1.000 37.26938 ? 138 ALA C CB  1 
ATOM   3366 N N   . PHE C 1 139 ? -4.79900  -33.21400 -19.82100 1.000 40.12789 ? 139 PHE C N   1 
ATOM   3367 C CA  . PHE C 1 139 ? -5.58700  -32.47500 -18.83500 1.000 40.07424 ? 139 PHE C CA  1 
ATOM   3368 C C   . PHE C 1 139 ? -7.08100  -32.76000 -18.99400 1.000 41.97207 ? 139 PHE C C   1 
ATOM   3369 O O   . PHE C 1 139 ? -7.76500  -33.10500 -18.02300 1.000 39.46174 ? 139 PHE C O   1 
ATOM   3370 C CB  . PHE C 1 139 ? -5.30900  -30.97000 -18.92800 1.000 34.53630 ? 139 PHE C CB  1 
ATOM   3371 C CG  . PHE C 1 139 ? -5.99200  -30.15900 -17.83200 1.000 46.36966 ? 139 PHE C CG  1 
ATOM   3372 C CD1 . PHE C 1 139 ? -6.13700  -30.67800 -16.53900 1.000 51.25024 ? 139 PHE C CD1 1 
ATOM   3373 C CD2 . PHE C 1 139 ? -6.51300  -28.90200 -18.09700 1.000 42.17222 ? 139 PHE C CD2 1 
ATOM   3374 C CE1 . PHE C 1 139 ? -6.77800  -29.94500 -15.53700 1.000 50.57409 ? 139 PHE C CE1 1 
ATOM   3375 C CE2 . PHE C 1 139 ? -7.14900  -28.16500 -17.10400 1.000 39.79411 ? 139 PHE C CE2 1 
ATOM   3376 C CZ  . PHE C 1 139 ? -7.27700  -28.68200 -15.82700 1.000 48.27392 ? 139 PHE C CZ  1 
ATOM   3377 N N   . MET C 1 140 ? -7.60600  -32.61500 -20.21400 1.000 40.86013 ? 140 MET C N   1 
ATOM   3378 C CA  . MET C 1 140 ? -9.02200  -32.88400 -20.44600 1.000 43.06827 ? 140 MET C CA  1 
ATOM   3379 C C   . MET C 1 140 ? -9.39500  -34.29800 -20.03200 1.000 38.37584 ? 140 MET C C   1 
ATOM   3380 O O   . MET C 1 140 ? -10.47400 -34.51500 -19.47000 1.000 40.14915 ? 140 MET C O   1 
ATOM   3381 C CB  . MET C 1 140 ? -9.36200  -32.67900 -21.92100 1.000 38.31539 ? 140 MET C CB  1 
ATOM   3382 C CG  . MET C 1 140 ? -9.10900  -31.29100 -22.42700 1.000 39.36329 ? 140 MET C CG  1 
ATOM   3383 S SD  . MET C 1 140 ? -9.55400  -31.21100 -24.16100 1.000 42.55881 ? 140 MET C SD  1 
ATOM   3384 C CE  . MET C 1 140 ? -9.47100  -29.45100 -24.44000 1.000 39.94766 ? 140 MET C CE  1 
ATOM   3385 N N   . GLU C 1 141 ? -8.51800  -35.27100 -20.32500 1.000 42.41674 ? 141 GLU C N   1 
ATOM   3386 C CA  . GLU C 1 141 ? -8.79200  -36.67600 -20.02600 1.000 43.95880 ? 141 GLU C CA  1 
ATOM   3387 C C   . GLU C 1 141 ? -9.16200  -36.89300 -18.56000 1.000 41.97214 ? 141 GLU C C   1 
ATOM   3388 O O   . GLU C 1 141 ? -10.01200 -37.74500 -18.25900 1.000 45.53682 ? 141 GLU C O   1 
ATOM   3389 C CB  . GLU C 1 141 ? -7.58500  -37.54100 -20.38800 1.000 42.93896 ? 141 GLU C CB  1 
ATOM   3390 C CG  . GLU C 1 141 ? -7.56900  -38.11800 -21.79900 1.000 45.36948 ? 141 GLU C CG  1 
ATOM   3391 C CD  . GLU C 1 141 ? -6.27100  -38.88400 -22.09600 1.000 54.54888 ? 141 GLU C CD  1 
ATOM   3392 O OE1 . GLU C 1 141 ? -5.51000  -39.19900 -21.14500 1.000 51.02006 ? 141 GLU C OE1 1 
ATOM   3393 O OE2 . GLU C 1 141 ? -6.00400  -39.16300 -23.28700 1.000 62.87567 ? 141 GLU C OE2 1 
ATOM   3394 N N   . THR C 1 142 ? -8.54700  -36.13100 -17.64100 1.000 45.88881 ? 142 THR C N   1 
ATOM   3395 C CA  . THR C 1 142 ? -8.79700  -36.28100 -16.20900 1.000 47.67380 ? 142 THR C CA  1 
ATOM   3396 C C   . THR C 1 142 ? -10.18600 -35.81600 -15.78100 1.000 47.84950 ? 142 THR C C   1 
ATOM   3397 O O   . THR C 1 142 ? -10.54400 -35.99900 -14.61200 1.000 46.39732 ? 142 THR C O   1 
ATOM   3398 C CB  . THR C 1 142 ? -7.74300  -35.51400 -15.38800 1.000 52.70448 ? 142 THR C CB  1 
ATOM   3399 O OG1 . THR C 1 142 ? -8.12900  -34.13300 -15.24600 1.000 54.59423 ? 142 THR C OG1 1 
ATOM   3400 C CG2 . THR C 1 142 ? -6.35800  -35.61300 -16.03000 1.000 46.77686 ? 142 THR C CG2 1 
ATOM   3401 N N   . ASN C 1 143 ? -10.97200 -35.22000 -16.67800 1.000 44.23187 ? 143 ASN C N   1 
ATOM   3402 C CA  . ASN C 1 143 ? -12.27600 -34.69700 -16.28000 1.000 46.46518 ? 143 ASN C CA  1 
ATOM   3403 C C   . ASN C 1 143 ? -13.40500 -35.54600 -16.85200 1.000 41.51449 ? 143 ASN C C   1 
ATOM   3404 O O   . ASN C 1 143 ? -14.20400 -35.06300 -17.66400 1.000 43.49138 ? 143 ASN C O   1 
ATOM   3405 C CB  . ASN C 1 143 ? -12.40900 -33.23600 -16.70800 1.000 42.02913 ? 143 ASN C CB  1 
ATOM   3406 C CG  . ASN C 1 143 ? -11.65400 -32.29400 -15.77900 1.000 46.77127 ? 143 ASN C CG  1 
ATOM   3407 O OD1 . ASN C 1 143 ? -11.52900 -31.10100 -16.04200 1.000 52.02122 ? 143 ASN C OD1 1 
ATOM   3408 N ND2 . ASN C 1 143 ? -11.15500 -32.84100 -14.66400 1.000 49.61992 ? 143 ASN C ND2 1 
ATOM   3409 N N   . VAL C 1 144 ? -13.48600 -36.80600 -16.42300 1.000 39.41804 ? 144 VAL C N   1 
ATOM   3410 C CA  . VAL C 1 144 ? -14.47500 -37.75000 -16.92800 1.000 37.93100 ? 144 VAL C CA  1 
ATOM   3411 C C   . VAL C 1 144 ? -14.91900 -38.64700 -15.78400 1.000 43.60994 ? 144 VAL C C   1 
ATOM   3412 O O   . VAL C 1 144 ? -14.08600 -39.17900 -15.04600 1.000 41.56920 ? 144 VAL C O   1 
ATOM   3413 C CB  . VAL C 1 144 ? -13.92700 -38.58900 -18.10100 1.000 37.99101 ? 144 VAL C CB  1 
ATOM   3414 C CG1 . VAL C 1 144 ? -14.88300 -39.71900 -18.44200 1.000 42.54021 ? 144 VAL C CG1 1 
ATOM   3415 C CG2 . VAL C 1 144 ? -13.68900 -37.71900 -19.32000 1.000 38.32453 ? 144 VAL C CG2 1 
ATOM   3416 N N   . ASP C 1 145 ? -16.22800 -38.82400 -15.64900 1.000 47.76620 ? 145 ASP C N   1 
ATOM   3417 C CA  . ASP C 1 145 ? -16.79300 -39.61800 -14.57300 1.000 45.95788 ? 145 ASP C CA  1 
ATOM   3418 C C   . ASP C 1 145 ? -17.73600 -40.69800 -15.11500 1.000 54.05375 ? 145 ASP C C   1 
ATOM   3419 O O   . ASP C 1 145 ? -17.30000 -41.78700 -15.51100 1.000 54.49224 ? 145 ASP C O   1 
ATOM   3420 C CB  . ASP C 1 145 ? -17.52700 -38.70800 -13.59800 1.000 48.21434 ? 145 ASP C CB  1 
ATOM   3421 C CG  . ASP C 1 145 ? -18.22800 -39.47700 -12.49100 1.000 56.50639 ? 145 ASP C CG  1 
ATOM   3422 O OD1 . ASP C 1 145 ? -19.38000 -39.90500 -12.71200 1.000 61.37026 ? 145 ASP C OD1 1 
ATOM   3423 O OD2 . ASP C 1 145 ? -17.63500 -39.64600 -11.40100 1.000 50.60141 ? 145 ASP C OD2 1 
HETATM 3424 O O   . HOH D 2 .   ? -30.90300 15.04800  -31.84300 1.000 54.96619 ? 201 HOH A O   1 
HETATM 3425 O O   . HOH D 2 .   ? -18.34200 -1.23900  -31.66900 1.000 34.57741 ? 202 HOH A O   1 
HETATM 3426 O O   . HOH D 2 .   ? -13.03800 -15.20200 -6.48800  1.000 37.77270 ? 203 HOH A O   1 
HETATM 3427 O O   . HOH D 2 .   ? -27.62900 9.59700   -28.42800 1.000 33.69219 ? 204 HOH A O   1 
HETATM 3428 O O   . HOH D 2 .   ? -19.79600 -32.09400 -15.82300 1.000 35.10810 ? 205 HOH A O   1 
HETATM 3429 O O   . HOH D 2 .   ? -22.04600 -2.02600  -37.05300 1.000 33.49889 ? 206 HOH A O   1 
HETATM 3430 O O   . HOH D 2 .   ? -19.15500 -3.68900  -27.98900 1.000 38.04433 ? 207 HOH A O   1 
HETATM 3431 O O   . HOH D 2 .   ? -17.04100 -22.29200 -7.96000  1.000 28.32255 ? 208 HOH A O   1 
HETATM 3432 O O   . HOH D 2 .   ? -21.14300 -9.16900  -33.08300 1.000 22.72386 ? 209 HOH A O   1 
HETATM 3433 O O   . HOH D 2 .   ? -26.57600 -4.58200  -33.24600 1.000 26.90460 ? 210 HOH A O   1 
HETATM 3434 O O   . HOH D 2 .   ? -19.89300 -4.04600  -38.01000 1.000 28.28063 ? 211 HOH A O   1 
HETATM 3435 O O   . HOH D 2 .   ? -10.85000 -25.54500 -17.47600 1.000 35.20332 ? 212 HOH A O   1 
HETATM 3436 O O   . HOH D 2 .   ? -10.68000 -26.10800 -14.77900 1.000 35.99559 ? 213 HOH A O   1 
HETATM 3437 O O   . HOH D 2 .   ? -21.39100 -5.26900  -28.14200 1.000 27.88943 ? 214 HOH A O   1 
HETATM 3438 O O   . HOH D 2 .   ? -7.11700  -20.79300 -28.55900 1.000 36.65689 ? 215 HOH A O   1 
HETATM 3439 O O   . HOH D 2 .   ? -25.05300 -14.84700 -8.37700  1.000 30.07373 ? 216 HOH A O   1 
HETATM 3440 O O   . HOH D 2 .   ? -28.53500 16.96600  -18.64200 1.000 36.85254 ? 217 HOH A O   1 
HETATM 3441 O O   . HOH D 2 .   ? -15.75600 -25.41100 -8.61000  1.000 26.28537 ? 218 HOH A O   1 
HETATM 3442 O O   . HOH D 2 .   ? -22.10000 -3.82200  -26.65800 1.000 28.85868 ? 219 HOH A O   1 
HETATM 3443 O O   . HOH D 2 .   ? -25.26600 -15.84600 -11.54000 1.000 23.73389 ? 220 HOH A O   1 
HETATM 3444 O O   . HOH D 2 .   ? -14.25100 -22.48300 -10.65700 1.000 36.42373 ? 221 HOH A O   1 
HETATM 3445 O O   . HOH D 2 .   ? -16.12200 -6.77700  -37.13500 1.000 25.80900 ? 222 HOH A O   1 
HETATM 3446 O O   . HOH D 2 .   ? -16.64900 -20.64600 -12.00300 1.000 33.80034 ? 223 HOH A O   1 
HETATM 3447 O O   . HOH D 2 .   ? -12.27200 -19.37200 -10.13900 1.000 34.62171 ? 224 HOH A O   1 
HETATM 3448 O O   . HOH D 2 .   ? -19.74300 -18.66300 -10.34400 1.000 28.26009 ? 225 HOH A O   1 
HETATM 3449 O O   . HOH D 2 .   ? -19.03400 -8.62100  -31.10100 1.000 27.94641 ? 226 HOH A O   1 
HETATM 3450 O O   . HOH D 2 .   ? -25.43500 -16.83700 -25.26600 1.000 32.31080 ? 227 HOH A O   1 
HETATM 3451 O O   . HOH D 2 .   ? -32.60100 5.38500   -25.78700 1.000 29.66927 ? 228 HOH A O   1 
HETATM 3452 O O   . HOH D 2 .   ? -15.12600 -21.35900 -1.80900  1.000 38.13181 ? 229 HOH A O   1 
HETATM 3453 O O   . HOH D 2 .   ? -30.93400 -3.71600  -33.73000 1.000 36.35568 ? 230 HOH A O   1 
HETATM 3454 O O   . HOH D 2 .   ? -14.77500 -13.42000 -40.39400 1.000 31.91557 ? 231 HOH A O   1 
HETATM 3455 O O   . HOH D 2 .   ? -24.85100 -3.51500  -37.03700 1.000 38.88637 ? 232 HOH A O   1 
HETATM 3456 O O   . HOH D 2 .   ? -25.20300 -15.63800 -30.43800 1.000 30.33363 ? 233 HOH A O   1 
HETATM 3457 O O   . HOH D 2 .   ? -9.46300  -26.95100 -10.07500 1.000 49.55973 ? 234 HOH A O   1 
HETATM 3458 O O   . HOH D 2 .   ? -16.92900 -2.58900  -34.15100 1.000 34.14864 ? 235 HOH A O   1 
HETATM 3459 O O   . HOH D 2 .   ? -27.65000 -15.53900 -29.17100 1.000 45.99982 ? 236 HOH A O   1 
HETATM 3460 O O   . HOH D 2 .   ? -30.95400 2.22600   -31.54000 1.000 46.59390 ? 237 HOH A O   1 
HETATM 3461 O O   . HOH D 2 .   ? -17.49100 -3.80800  -36.46400 1.000 40.43635 ? 238 HOH A O   1 
HETATM 3462 O O   . HOH D 2 .   ? -32.97300 1.50600   -30.98400 1.000 41.53560 ? 239 HOH A O   1 
HETATM 3463 O O   . HOH E 2 .   ? -44.49800 -2.70100  -15.19000 1.000 34.12067 ? 201 HOH B O   1 
HETATM 3464 O O   . HOH E 2 .   ? -47.19700 -0.99700  -21.15700 1.000 46.54476 ? 202 HOH B O   1 
HETATM 3465 O O   . HOH E 2 .   ? -53.12100 -10.11600 -10.23000 1.000 50.46750 ? 203 HOH B O   1 
HETATM 3466 O O   . HOH E 2 .   ? -21.16100 -3.68200  -7.30100  1.000 31.80814 ? 204 HOH B O   1 
HETATM 3467 O O   . HOH E 2 .   ? -43.69300 -14.94900 -23.33000 1.000 32.68957 ? 205 HOH B O   1 
HETATM 3468 O O   . HOH E 2 .   ? -31.86400 7.31400   -18.82800 1.000 40.96800 ? 206 HOH B O   1 
HETATM 3469 O O   . HOH E 2 .   ? -29.89900 -8.65000  -0.17200  1.000 40.20847 ? 207 HOH B O   1 
HETATM 3470 O O   . HOH E 2 .   ? -25.27500 -10.34000 -9.16700  1.000 26.05627 ? 208 HOH B O   1 
HETATM 3471 O O   . HOH E 2 .   ? -31.41000 10.18500  -16.82400 1.000 41.95021 ? 209 HOH B O   1 
HETATM 3472 O O   . HOH E 2 .   ? -22.44800 -6.60400  -6.96400  1.000 27.23966 ? 210 HOH B O   1 
HETATM 3473 O O   . HOH E 2 .   ? -27.90900 -3.42900  -7.02900  1.000 25.76548 ? 211 HOH B O   1 
HETATM 3474 O O   . HOH E 2 .   ? -46.61000 -13.89400 -25.99800 1.000 30.72939 ? 212 HOH B O   1 
HETATM 3475 O O   . HOH E 2 .   ? -39.44800 -12.43300 -29.41100 1.000 24.28967 ? 213 HOH B O   1 
HETATM 3476 O O   . HOH E 2 .   ? -15.30500 -2.64300  -16.69200 1.000 27.34975 ? 214 HOH B O   1 
HETATM 3477 O O   . HOH E 2 .   ? -41.49400 -16.94800 -22.61400 1.000 31.01667 ? 215 HOH B O   1 
HETATM 3478 O O   . HOH E 2 .   ? -29.90300 -19.07200 -8.60700  1.000 29.13421 ? 216 HOH B O   1 
HETATM 3479 O O   . HOH E 2 .   ? -39.98300 -10.97600 -26.90200 1.000 31.48260 ? 217 HOH B O   1 
HETATM 3480 O O   . HOH E 2 .   ? -40.67700 -19.25200 -30.55000 1.000 27.60917 ? 218 HOH B O   1 
HETATM 3481 O O   . HOH E 2 .   ? -24.76200 -3.66500  -8.71300  1.000 32.59191 ? 219 HOH B O   1 
HETATM 3482 O O   . HOH E 2 .   ? -24.79700 2.32300   -15.03900 1.000 28.81704 ? 220 HOH B O   1 
HETATM 3483 O O   . HOH E 2 .   ? -35.78200 -27.79700 -29.91600 1.000 27.68605 ? 221 HOH B O   1 
HETATM 3484 O O   . HOH E 2 .   ? -52.71300 -16.24700 -6.47400  1.000 46.73903 ? 222 HOH B O   1 
HETATM 3485 O O   . HOH E 2 .   ? -35.53700 -25.65100 -31.54800 1.000 26.58741 ? 223 HOH B O   1 
HETATM 3486 O O   . HOH E 2 .   ? -51.92300 -5.32800  -10.12900 1.000 47.36403 ? 224 HOH B O   1 
HETATM 3487 O O   . HOH E 2 .   ? -32.80600 5.03800   -3.40900  1.000 41.91860 ? 225 HOH B O   1 
HETATM 3488 O O   . HOH E 2 .   ? -38.24000 -12.79000 -33.40000 1.000 36.87551 ? 226 HOH B O   1 
HETATM 3489 O O   . HOH E 2 .   ? -44.54700 -8.66700  -31.44600 1.000 25.22365 ? 227 HOH B O   1 
HETATM 3490 O O   . HOH E 2 .   ? -54.03600 -17.37400 -26.63300 1.000 46.05376 ? 228 HOH B O   1 
HETATM 3491 O O   . HOH E 2 .   ? -25.08000 -6.35300  -10.37100 1.000 30.62432 ? 229 HOH B O   1 
HETATM 3492 O O   . HOH E 2 .   ? -34.53500 -1.59700  -1.27000  1.000 25.15073 ? 230 HOH B O   1 
HETATM 3493 O O   . HOH E 2 .   ? -40.92100 -14.87400 -24.02600 1.000 29.04032 ? 231 HOH B O   1 
HETATM 3494 O O   . HOH E 2 .   ? -23.24800 -7.66400  1.40800   1.000 43.79054 ? 232 HOH B O   1 
HETATM 3495 O O   . HOH E 2 .   ? -23.07800 -2.36000  -8.73800  1.000 31.14325 ? 233 HOH B O   1 
HETATM 3496 O O   . HOH E 2 .   ? -46.56100 -11.69600 -27.89500 1.000 34.84200 ? 234 HOH B O   1 
HETATM 3497 O O   . HOH E 2 .   ? -32.39400 0.00000   0.00000   0.50  32.29540 ? 235 HOH B O   1 
HETATM 3498 O O   . HOH E 2 .   ? -50.08900 -25.46900 -28.08900 1.000 45.08831 ? 236 HOH B O   1 
HETATM 3499 O O   . HOH E 2 .   ? -54.05500 -33.91500 -13.50200 1.000 40.14870 ? 237 HOH B O   1 
HETATM 3500 O O   . HOH E 2 .   ? -30.73800 -13.70800 -29.08100 1.000 30.75047 ? 238 HOH B O   1 
HETATM 3501 O O   . HOH E 2 .   ? -54.50300 -18.98700 -27.66100 1.000 39.51065 ? 239 HOH B O   1 
HETATM 3502 O O   . HOH E 2 .   ? -37.696   -16.307   -36.346   1.000 36.77808 ? 240 HOH B O   1 
HETATM 3503 O O   . HOH F 2 .   ? -26.04200 -16.31200 -14.44600 1.000 27.99091 ? 201 HOH C O   1 
HETATM 3504 O O   . HOH F 2 .   ? -6.16700  -33.31500 -36.00600 1.000 46.05860 ? 202 HOH C O   1 
HETATM 3505 O O   . HOH F 2 .   ? -27.41000 -26.56000 -31.78300 1.000 23.90408 ? 203 HOH C O   1 
HETATM 3506 O O   . HOH F 2 .   ? -21.61900 -32.71400 -30.92600 1.000 38.69939 ? 204 HOH C O   1 
HETATM 3507 O O   . HOH F 2 .   ? -22.03100 -30.60100 -27.33600 1.000 35.74168 ? 205 HOH C O   1 
HETATM 3508 O O   . HOH F 2 .   ? -14.32500 -36.70200 -35.61500 1.000 50.02881 ? 206 HOH C O   1 
HETATM 3509 O O   . HOH F 2 .   ? -36.34600 -19.23400 -4.40300  1.000 26.20880 ? 207 HOH C O   1 
HETATM 3510 O O   . HOH F 2 .   ? -28.62300 -38.68000 -18.06700 1.000 37.54100 ? 208 HOH C O   1 
HETATM 3511 O O   . HOH F 2 .   ? -41.09400 -23.35400 -8.75500  1.000 43.28046 ? 209 HOH C O   1 
HETATM 3512 O O   . HOH F 2 .   ? -15.57000 -16.35400 -34.16300 1.000 24.56348 ? 210 HOH C O   1 
HETATM 3513 O O   . HOH F 2 .   ? -42.67100 -35.26000 -11.52800 1.000 41.29236 ? 211 HOH C O   1 
HETATM 3514 O O   . HOH F 2 .   ? -28.18900 -24.72000 -34.83800 1.000 30.84269 ? 212 HOH C O   1 
HETATM 3515 O O   . HOH F 2 .   ? -42.52900 -32.12100 -21.60800 1.000 44.07373 ? 213 HOH C O   1 
HETATM 3516 O O   . HOH F 2 .   ? -34.70300 -21.96600 -6.91100  1.000 28.65490 ? 214 HOH C O   1 
HETATM 3517 O O   . HOH F 2 .   ? -5.38000  -37.63500 -17.88800 1.000 45.36129 ? 215 HOH C O   1 
HETATM 3518 O O   . HOH F 2 .   ? -33.54200 -19.18700 -4.79000  1.000 27.66541 ? 216 HOH C O   1 
HETATM 3519 O O   . HOH F 2 .   ? -20.77900 -27.57500 -27.11000 1.000 34.60530 ? 217 HOH C O   1 
HETATM 3520 O O   . HOH F 2 .   ? -42.58100 -13.44700 -11.50500 1.000 26.42506 ? 218 HOH C O   1 
HETATM 3521 O O   . HOH F 2 .   ? -21.30000 -24.24200 -34.29400 1.000 27.86334 ? 219 HOH C O   1 
HETATM 3522 O O   . HOH F 2 .   ? -28.46500 -26.35600 -3.52300  1.000 37.02273 ? 220 HOH C O   1 
HETATM 3523 O O   . HOH F 2 .   ? -5.40900  -20.05100 -25.66900 1.000 38.20379 ? 221 HOH C O   1 
HETATM 3524 O O   . HOH F 2 .   ? -42.01600 -23.94400 -11.36000 1.000 26.55230 ? 222 HOH C O   1 
HETATM 3525 O O   . HOH F 2 .   ? -25.54600 -17.32900 -35.84200 1.000 41.46413 ? 223 HOH C O   1 
HETATM 3526 O O   . HOH F 2 .   ? -29.23000 -25.99500 -36.48900 1.000 29.17560 ? 224 HOH C O   1 
HETATM 3527 O O   . HOH F 2 .   ? -37.35100 -37.70600 -31.39500 1.000 54.03557 ? 225 HOH C O   1 
HETATM 3528 O O   . HOH F 2 .   ? -24.44800 -27.98800 -0.50700  1.000 42.21263 ? 226 HOH C O   1 
HETATM 3529 O O   . HOH F 2 .   ? -33.11000 -20.85800 -8.84200  1.000 28.23668 ? 227 HOH C O   1 
HETATM 3530 O O   . HOH F 2 .   ? -32.945   -25.139   -34.830   1.000 35.32452 ? 228 HOH C O   1 
HETATM 3531 O O   . HOH F 2 .   ? -18.26700 -16.73200 -34.86400 1.000 30.73311 ? 229 HOH C O   1 
HETATM 3532 O O   . HOH F 2 .   ? -28.65000 -32.83300 -34.50900 1.000 27.42135 ? 230 HOH C O   1 
HETATM 3533 O O   . HOH F 2 .   ? -29.95700 -17.72400 -24.44600 1.000 35.53682 ? 231 HOH C O   1 
HETATM 3534 O O   . HOH F 2 .   ? -40.73600 -31.80300 -5.21600  1.000 39.50436 ? 232 HOH C O   1 
HETATM 3535 O O   . HOH F 2 .   ? -23.84900 -18.17500 -2.89900  1.000 38.95936 ? 233 HOH C O   1 
HETATM 3536 O O   . HOH F 2 .   ? -12.41700 -18.54200 -34.59900 1.000 33.09854 ? 234 HOH C O   1 
HETATM 3537 O O   . HOH F 2 .   ? -16.03200 -37.86900 -33.39000 1.000 39.89118 ? 235 HOH C O   1 
HETATM 3538 O O   . HOH F 2 .   ? -22.36000 -28.16400 -27.32300 1.000 32.77584 ? 236 HOH C O   1 
HETATM 3539 O O   . HOH F 2 .   ? -12.06600 -20.92200 -34.97100 1.000 39.30541 ? 237 HOH C O   1 
# 
