data_9NOV
# 
_entry.id   9NOV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9NOV         pdb_00009nov 10.2210/pdb9nov/pdb 
WWPDB D_1000293565 ?            ?                   
EMDB  EMD-49618    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-05-14 ? 
2 'Structure model' 1 1 2025-05-21 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.country'                 
2 2 'Structure model' '_citation.journal_abbrev'          
3 2 'Structure model' '_citation.journal_id_ASTM'         
4 2 'Structure model' '_citation.journal_id_CSD'          
5 2 'Structure model' '_citation.journal_id_ISSN'         
6 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7 2 'Structure model' '_citation.title'                   
8 2 'Structure model' '_citation_author.name'             
9 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9NOV 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to sucralose' 
_pdbx_database_related.db_id          EMD-49618 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              cz2195@columbia.edu 
_pdbx_contact_author.name_first         Charles 
_pdbx_contact_author.name_last          Zuker 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5201-8718 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Juen, Z.'            1 ? 
'Lu, Z.'              2 ? 
'Yu, R.'              3 ? 
'Chang, A.N.'         4 ? 
'Wang, B.'            5 ? 
'Fitzpatrick, A.W.P.' 6 ? 
'Zuker, C.S.'         7 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Cell 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1097-4172 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'The structure of human sweetness.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cell.2025.04.021 
_citation.pdbx_database_id_PubMed   40339580 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Juen, Z.'            1 ? 
primary 'Lu, Z.'              2 ? 
primary 'Yu, R.'              3 ? 
primary 'Chang, A.N.'         4 ? 
primary 'Wang, B.'            5 ? 
primary 'Fitzpatrick, A.W.P.' 6 ? 
primary 'Zuker, C.S.'         7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Taste receptor type 1 member 3'                                                                58379.551 1  ? ? 
? ? 
2 polymer     man 'Taste receptor type 1 member 2'                                                                60070.512 1  ? ? 
? ? 
3 branched    man '4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose' 397.634   1  ? ? 
? ? 
4 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose                                                        221.208   15 ? ? 
? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Sweet taste receptor T1R3'                               
2 'G-protein coupled receptor 71,Sweet taste receptor T1R2' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFADYKDDDDKAAAAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWA
LAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVT
GKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAAR
GICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLP
GMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSV
YAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGR
FNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDC
;
;MKTIIALSYIFCLVFADYKDDDDKAAAAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWA
LAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVT
GKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAAR
GICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLP
GMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSV
YAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGR
FNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDC
;
B ? 
2 'polypeptide(L)' no no 
;MKTIIALSYIFCLVFAYPYDVPDYAAAAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNL
MQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVA
NFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRD
ICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLH
NLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSA
VYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPL
QRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECI
;
;MKTIIALSYIFCLVFAYPYDVPDYAAAAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNL
MQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVA
NFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRD
ICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLH
NLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSA
VYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPL
QRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECI
;
A ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   THR n 
1 4   ILE n 
1 5   ILE n 
1 6   ALA n 
1 7   LEU n 
1 8   SER n 
1 9   TYR n 
1 10  ILE n 
1 11  PHE n 
1 12  CYS n 
1 13  LEU n 
1 14  VAL n 
1 15  PHE n 
1 16  ALA n 
1 17  ASP n 
1 18  TYR n 
1 19  LYS n 
1 20  ASP n 
1 21  ASP n 
1 22  ASP n 
1 23  ASP n 
1 24  LYS n 
1 25  ALA n 
1 26  ALA n 
1 27  ALA n 
1 28  ALA n 
1 29  PRO n 
1 30  LEU n 
1 31  CYS n 
1 32  LEU n 
1 33  SER n 
1 34  GLN n 
1 35  GLN n 
1 36  LEU n 
1 37  ARG n 
1 38  MET n 
1 39  LYS n 
1 40  GLY n 
1 41  ASP n 
1 42  TYR n 
1 43  VAL n 
1 44  LEU n 
1 45  GLY n 
1 46  GLY n 
1 47  LEU n 
1 48  PHE n 
1 49  PRO n 
1 50  LEU n 
1 51  GLY n 
1 52  GLU n 
1 53  ALA n 
1 54  GLU n 
1 55  GLU n 
1 56  ALA n 
1 57  GLY n 
1 58  LEU n 
1 59  ARG n 
1 60  SER n 
1 61  ARG n 
1 62  THR n 
1 63  ARG n 
1 64  PRO n 
1 65  SER n 
1 66  SER n 
1 67  PRO n 
1 68  VAL n 
1 69  CYS n 
1 70  THR n 
1 71  ARG n 
1 72  PHE n 
1 73  SER n 
1 74  SER n 
1 75  ASN n 
1 76  GLY n 
1 77  LEU n 
1 78  LEU n 
1 79  TRP n 
1 80  ALA n 
1 81  LEU n 
1 82  ALA n 
1 83  MET n 
1 84  LYS n 
1 85  MET n 
1 86  ALA n 
1 87  VAL n 
1 88  GLU n 
1 89  GLU n 
1 90  ILE n 
1 91  ASN n 
1 92  ASN n 
1 93  LYS n 
1 94  SER n 
1 95  ASP n 
1 96  LEU n 
1 97  LEU n 
1 98  PRO n 
1 99  GLY n 
1 100 LEU n 
1 101 ARG n 
1 102 LEU n 
1 103 GLY n 
1 104 TYR n 
1 105 ASP n 
1 106 LEU n 
1 107 PHE n 
1 108 ASP n 
1 109 THR n 
1 110 CYS n 
1 111 SER n 
1 112 GLU n 
1 113 PRO n 
1 114 VAL n 
1 115 VAL n 
1 116 ALA n 
1 117 MET n 
1 118 LYS n 
1 119 PRO n 
1 120 SER n 
1 121 LEU n 
1 122 MET n 
1 123 PHE n 
1 124 LEU n 
1 125 ALA n 
1 126 LYS n 
1 127 ALA n 
1 128 GLY n 
1 129 SER n 
1 130 ARG n 
1 131 ASP n 
1 132 ILE n 
1 133 ALA n 
1 134 ALA n 
1 135 TYR n 
1 136 CYS n 
1 137 ASN n 
1 138 TYR n 
1 139 THR n 
1 140 GLN n 
1 141 TYR n 
1 142 GLN n 
1 143 PRO n 
1 144 ARG n 
1 145 VAL n 
1 146 LEU n 
1 147 ALA n 
1 148 VAL n 
1 149 ILE n 
1 150 GLY n 
1 151 PRO n 
1 152 HIS n 
1 153 SER n 
1 154 SER n 
1 155 GLU n 
1 156 LEU n 
1 157 ALA n 
1 158 MET n 
1 159 VAL n 
1 160 THR n 
1 161 GLY n 
1 162 LYS n 
1 163 PHE n 
1 164 PHE n 
1 165 SER n 
1 166 PHE n 
1 167 PHE n 
1 168 LEU n 
1 169 MET n 
1 170 PRO n 
1 171 GLN n 
1 172 VAL n 
1 173 SER n 
1 174 TYR n 
1 175 GLY n 
1 176 ALA n 
1 177 SER n 
1 178 MET n 
1 179 GLU n 
1 180 LEU n 
1 181 LEU n 
1 182 SER n 
1 183 ALA n 
1 184 ARG n 
1 185 GLU n 
1 186 THR n 
1 187 PHE n 
1 188 PRO n 
1 189 SER n 
1 190 PHE n 
1 191 PHE n 
1 192 ARG n 
1 193 THR n 
1 194 VAL n 
1 195 PRO n 
1 196 SER n 
1 197 ASP n 
1 198 ARG n 
1 199 VAL n 
1 200 GLN n 
1 201 LEU n 
1 202 THR n 
1 203 ALA n 
1 204 ALA n 
1 205 ALA n 
1 206 GLU n 
1 207 LEU n 
1 208 LEU n 
1 209 GLN n 
1 210 GLU n 
1 211 PHE n 
1 212 GLY n 
1 213 TRP n 
1 214 ASN n 
1 215 TRP n 
1 216 VAL n 
1 217 ALA n 
1 218 ALA n 
1 219 LEU n 
1 220 GLY n 
1 221 SER n 
1 222 ASP n 
1 223 ASP n 
1 224 GLU n 
1 225 TYR n 
1 226 GLY n 
1 227 ARG n 
1 228 GLN n 
1 229 GLY n 
1 230 LEU n 
1 231 SER n 
1 232 ILE n 
1 233 PHE n 
1 234 SER n 
1 235 ALA n 
1 236 LEU n 
1 237 ALA n 
1 238 ALA n 
1 239 ALA n 
1 240 ARG n 
1 241 GLY n 
1 242 ILE n 
1 243 CYS n 
1 244 ILE n 
1 245 ALA n 
1 246 HIS n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 VAL n 
1 251 PRO n 
1 252 LEU n 
1 253 PRO n 
1 254 ARG n 
1 255 ALA n 
1 256 ASP n 
1 257 ASP n 
1 258 SER n 
1 259 ARG n 
1 260 LEU n 
1 261 GLY n 
1 262 LYS n 
1 263 VAL n 
1 264 GLN n 
1 265 ASP n 
1 266 VAL n 
1 267 LEU n 
1 268 HIS n 
1 269 GLN n 
1 270 VAL n 
1 271 ASN n 
1 272 GLN n 
1 273 SER n 
1 274 SER n 
1 275 VAL n 
1 276 GLN n 
1 277 VAL n 
1 278 VAL n 
1 279 LEU n 
1 280 LEU n 
1 281 PHE n 
1 282 ALA n 
1 283 SER n 
1 284 VAL n 
1 285 HIS n 
1 286 ALA n 
1 287 ALA n 
1 288 HIS n 
1 289 ALA n 
1 290 LEU n 
1 291 PHE n 
1 292 ASN n 
1 293 TYR n 
1 294 SER n 
1 295 ILE n 
1 296 SER n 
1 297 SER n 
1 298 ARG n 
1 299 LEU n 
1 300 SER n 
1 301 PRO n 
1 302 LYS n 
1 303 VAL n 
1 304 TRP n 
1 305 VAL n 
1 306 ALA n 
1 307 SER n 
1 308 GLU n 
1 309 ALA n 
1 310 TRP n 
1 311 LEU n 
1 312 THR n 
1 313 SER n 
1 314 ASP n 
1 315 LEU n 
1 316 VAL n 
1 317 MET n 
1 318 GLY n 
1 319 LEU n 
1 320 PRO n 
1 321 GLY n 
1 322 MET n 
1 323 ALA n 
1 324 GLN n 
1 325 MET n 
1 326 GLY n 
1 327 THR n 
1 328 VAL n 
1 329 LEU n 
1 330 GLY n 
1 331 PHE n 
1 332 LEU n 
1 333 GLN n 
1 334 ARG n 
1 335 GLY n 
1 336 ALA n 
1 337 GLN n 
1 338 LEU n 
1 339 HIS n 
1 340 GLU n 
1 341 PHE n 
1 342 PRO n 
1 343 GLN n 
1 344 TYR n 
1 345 VAL n 
1 346 LYS n 
1 347 THR n 
1 348 HIS n 
1 349 LEU n 
1 350 ALA n 
1 351 LEU n 
1 352 ALA n 
1 353 THR n 
1 354 ASP n 
1 355 PRO n 
1 356 ALA n 
1 357 PHE n 
1 358 CYS n 
1 359 SER n 
1 360 ALA n 
1 361 LEU n 
1 362 GLY n 
1 363 GLU n 
1 364 ARG n 
1 365 GLU n 
1 366 GLN n 
1 367 GLY n 
1 368 LEU n 
1 369 GLU n 
1 370 GLU n 
1 371 ASP n 
1 372 VAL n 
1 373 VAL n 
1 374 GLY n 
1 375 GLN n 
1 376 ARG n 
1 377 CYS n 
1 378 PRO n 
1 379 GLN n 
1 380 CYS n 
1 381 ASP n 
1 382 CYS n 
1 383 ILE n 
1 384 THR n 
1 385 LEU n 
1 386 GLN n 
1 387 ASN n 
1 388 VAL n 
1 389 SER n 
1 390 ALA n 
1 391 GLY n 
1 392 LEU n 
1 393 ASN n 
1 394 HIS n 
1 395 HIS n 
1 396 GLN n 
1 397 THR n 
1 398 PHE n 
1 399 SER n 
1 400 VAL n 
1 401 TYR n 
1 402 ALA n 
1 403 ALA n 
1 404 VAL n 
1 405 TYR n 
1 406 SER n 
1 407 VAL n 
1 408 ALA n 
1 409 GLN n 
1 410 ALA n 
1 411 LEU n 
1 412 HIS n 
1 413 ASN n 
1 414 THR n 
1 415 LEU n 
1 416 GLN n 
1 417 CYS n 
1 418 ASN n 
1 419 ALA n 
1 420 SER n 
1 421 GLY n 
1 422 CYS n 
1 423 PRO n 
1 424 ALA n 
1 425 GLN n 
1 426 ASP n 
1 427 PRO n 
1 428 VAL n 
1 429 LYS n 
1 430 PRO n 
1 431 TRP n 
1 432 GLN n 
1 433 LEU n 
1 434 LEU n 
1 435 GLU n 
1 436 ASN n 
1 437 MET n 
1 438 TYR n 
1 439 ASN n 
1 440 LEU n 
1 441 THR n 
1 442 PHE n 
1 443 HIS n 
1 444 VAL n 
1 445 GLY n 
1 446 GLY n 
1 447 LEU n 
1 448 PRO n 
1 449 LEU n 
1 450 ARG n 
1 451 PHE n 
1 452 ASP n 
1 453 SER n 
1 454 SER n 
1 455 GLY n 
1 456 ASN n 
1 457 VAL n 
1 458 ASP n 
1 459 MET n 
1 460 GLU n 
1 461 TYR n 
1 462 ASP n 
1 463 LEU n 
1 464 LYS n 
1 465 LEU n 
1 466 TRP n 
1 467 VAL n 
1 468 TRP n 
1 469 GLN n 
1 470 GLY n 
1 471 SER n 
1 472 VAL n 
1 473 PRO n 
1 474 ARG n 
1 475 LEU n 
1 476 HIS n 
1 477 ASP n 
1 478 VAL n 
1 479 GLY n 
1 480 ARG n 
1 481 PHE n 
1 482 ASN n 
1 483 GLY n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 THR n 
1 488 GLU n 
1 489 ARG n 
1 490 LEU n 
1 491 LYS n 
1 492 ILE n 
1 493 ARG n 
1 494 TRP n 
1 495 HIS n 
1 496 THR n 
1 497 SER n 
1 498 ASP n 
1 499 ASN n 
1 500 GLN n 
1 501 LYS n 
1 502 PRO n 
1 503 VAL n 
1 504 SER n 
1 505 ARG n 
1 506 CYS n 
1 507 SER n 
1 508 ARG n 
1 509 GLN n 
1 510 CYS n 
1 511 GLN n 
1 512 GLU n 
1 513 GLY n 
1 514 GLN n 
1 515 VAL n 
1 516 ARG n 
1 517 ARG n 
1 518 VAL n 
1 519 LYS n 
1 520 GLY n 
1 521 PHE n 
1 522 HIS n 
1 523 SER n 
1 524 CYS n 
1 525 CYS n 
1 526 TYR n 
1 527 ASP n 
1 528 CYS n 
2 1   MET n 
2 2   LYS n 
2 3   THR n 
2 4   ILE n 
2 5   ILE n 
2 6   ALA n 
2 7   LEU n 
2 8   SER n 
2 9   TYR n 
2 10  ILE n 
2 11  PHE n 
2 12  CYS n 
2 13  LEU n 
2 14  VAL n 
2 15  PHE n 
2 16  ALA n 
2 17  TYR n 
2 18  PRO n 
2 19  TYR n 
2 20  ASP n 
2 21  VAL n 
2 22  PRO n 
2 23  ASP n 
2 24  TYR n 
2 25  ALA n 
2 26  ALA n 
2 27  ALA n 
2 28  ALA n 
2 29  GLU n 
2 30  PRO n 
2 31  ALA n 
2 32  GLU n 
2 33  ASN n 
2 34  SER n 
2 35  ASP n 
2 36  PHE n 
2 37  TYR n 
2 38  LEU n 
2 39  PRO n 
2 40  GLY n 
2 41  ASP n 
2 42  TYR n 
2 43  LEU n 
2 44  LEU n 
2 45  GLY n 
2 46  GLY n 
2 47  LEU n 
2 48  PHE n 
2 49  SER n 
2 50  LEU n 
2 51  HIS n 
2 52  ALA n 
2 53  ASN n 
2 54  MET n 
2 55  LYS n 
2 56  GLY n 
2 57  ILE n 
2 58  VAL n 
2 59  HIS n 
2 60  LEU n 
2 61  ASN n 
2 62  PHE n 
2 63  LEU n 
2 64  GLN n 
2 65  VAL n 
2 66  PRO n 
2 67  MET n 
2 68  CYS n 
2 69  LYS n 
2 70  GLU n 
2 71  TYR n 
2 72  GLU n 
2 73  VAL n 
2 74  LYS n 
2 75  VAL n 
2 76  ILE n 
2 77  GLY n 
2 78  TYR n 
2 79  ASN n 
2 80  LEU n 
2 81  MET n 
2 82  GLN n 
2 83  ALA n 
2 84  MET n 
2 85  ARG n 
2 86  PHE n 
2 87  ALA n 
2 88  VAL n 
2 89  GLU n 
2 90  GLU n 
2 91  ILE n 
2 92  ASN n 
2 93  ASN n 
2 94  ASP n 
2 95  SER n 
2 96  SER n 
2 97  LEU n 
2 98  LEU n 
2 99  PRO n 
2 100 GLY n 
2 101 VAL n 
2 102 LEU n 
2 103 LEU n 
2 104 GLY n 
2 105 TYR n 
2 106 GLU n 
2 107 ILE n 
2 108 VAL n 
2 109 ASP n 
2 110 VAL n 
2 111 CYS n 
2 112 TYR n 
2 113 ILE n 
2 114 SER n 
2 115 ASN n 
2 116 ASN n 
2 117 VAL n 
2 118 GLN n 
2 119 PRO n 
2 120 VAL n 
2 121 LEU n 
2 122 TYR n 
2 123 PHE n 
2 124 LEU n 
2 125 ALA n 
2 126 HIS n 
2 127 GLU n 
2 128 ASP n 
2 129 ASN n 
2 130 LEU n 
2 131 LEU n 
2 132 PRO n 
2 133 ILE n 
2 134 GLN n 
2 135 GLU n 
2 136 ASP n 
2 137 TYR n 
2 138 SER n 
2 139 ASN n 
2 140 TYR n 
2 141 ILE n 
2 142 SER n 
2 143 ARG n 
2 144 VAL n 
2 145 VAL n 
2 146 ALA n 
2 147 VAL n 
2 148 ILE n 
2 149 GLY n 
2 150 PRO n 
2 151 ASP n 
2 152 ASN n 
2 153 SER n 
2 154 GLU n 
2 155 SER n 
2 156 VAL n 
2 157 MET n 
2 158 THR n 
2 159 VAL n 
2 160 ALA n 
2 161 ASN n 
2 162 PHE n 
2 163 LEU n 
2 164 SER n 
2 165 LEU n 
2 166 PHE n 
2 167 LEU n 
2 168 LEU n 
2 169 PRO n 
2 170 GLN n 
2 171 ILE n 
2 172 THR n 
2 173 TYR n 
2 174 SER n 
2 175 ALA n 
2 176 ILE n 
2 177 SER n 
2 178 ASP n 
2 179 GLU n 
2 180 LEU n 
2 181 ARG n 
2 182 ASP n 
2 183 LYS n 
2 184 VAL n 
2 185 ARG n 
2 186 PHE n 
2 187 PRO n 
2 188 ALA n 
2 189 LEU n 
2 190 LEU n 
2 191 ARG n 
2 192 THR n 
2 193 THR n 
2 194 PRO n 
2 195 SER n 
2 196 ALA n 
2 197 ASP n 
2 198 HIS n 
2 199 HIS n 
2 200 ILE n 
2 201 GLU n 
2 202 ALA n 
2 203 MET n 
2 204 VAL n 
2 205 GLN n 
2 206 LEU n 
2 207 MET n 
2 208 LEU n 
2 209 HIS n 
2 210 PHE n 
2 211 ARG n 
2 212 TRP n 
2 213 ASN n 
2 214 TRP n 
2 215 ILE n 
2 216 ILE n 
2 217 VAL n 
2 218 LEU n 
2 219 VAL n 
2 220 SER n 
2 221 SER n 
2 222 ASP n 
2 223 THR n 
2 224 TYR n 
2 225 GLY n 
2 226 ARG n 
2 227 ASP n 
2 228 ASN n 
2 229 GLY n 
2 230 GLN n 
2 231 LEU n 
2 232 LEU n 
2 233 GLY n 
2 234 GLU n 
2 235 ARG n 
2 236 VAL n 
2 237 ALA n 
2 238 ARG n 
2 239 ARG n 
2 240 ASP n 
2 241 ILE n 
2 242 CYS n 
2 243 ILE n 
2 244 ALA n 
2 245 PHE n 
2 246 GLN n 
2 247 GLU n 
2 248 THR n 
2 249 LEU n 
2 250 PRO n 
2 251 THR n 
2 252 LEU n 
2 253 GLN n 
2 254 PRO n 
2 255 ASN n 
2 256 GLN n 
2 257 ASN n 
2 258 MET n 
2 259 THR n 
2 260 SER n 
2 261 GLU n 
2 262 GLU n 
2 263 ARG n 
2 264 GLN n 
2 265 ARG n 
2 266 LEU n 
2 267 VAL n 
2 268 THR n 
2 269 ILE n 
2 270 VAL n 
2 271 ASP n 
2 272 LYS n 
2 273 LEU n 
2 274 GLN n 
2 275 GLN n 
2 276 SER n 
2 277 THR n 
2 278 ALA n 
2 279 ARG n 
2 280 VAL n 
2 281 VAL n 
2 282 VAL n 
2 283 VAL n 
2 284 PHE n 
2 285 SER n 
2 286 PRO n 
2 287 ASP n 
2 288 LEU n 
2 289 THR n 
2 290 LEU n 
2 291 TYR n 
2 292 HIS n 
2 293 PHE n 
2 294 PHE n 
2 295 ASN n 
2 296 GLU n 
2 297 VAL n 
2 298 LEU n 
2 299 ARG n 
2 300 GLN n 
2 301 ASN n 
2 302 PHE n 
2 303 THR n 
2 304 GLY n 
2 305 ALA n 
2 306 VAL n 
2 307 TRP n 
2 308 ILE n 
2 309 ALA n 
2 310 SER n 
2 311 GLU n 
2 312 SER n 
2 313 TRP n 
2 314 ALA n 
2 315 ILE n 
2 316 ASP n 
2 317 PRO n 
2 318 VAL n 
2 319 LEU n 
2 320 HIS n 
2 321 ASN n 
2 322 LEU n 
2 323 THR n 
2 324 GLU n 
2 325 LEU n 
2 326 ARG n 
2 327 HIS n 
2 328 LEU n 
2 329 GLY n 
2 330 THR n 
2 331 PHE n 
2 332 LEU n 
2 333 GLY n 
2 334 ILE n 
2 335 THR n 
2 336 ILE n 
2 337 GLN n 
2 338 SER n 
2 339 VAL n 
2 340 PRO n 
2 341 ILE n 
2 342 PRO n 
2 343 GLY n 
2 344 PHE n 
2 345 SER n 
2 346 GLU n 
2 347 PHE n 
2 348 ARG n 
2 349 GLU n 
2 350 TRP n 
2 351 GLY n 
2 352 PRO n 
2 353 GLN n 
2 354 ALA n 
2 355 GLY n 
2 356 PRO n 
2 357 PRO n 
2 358 PRO n 
2 359 LEU n 
2 360 SER n 
2 361 ARG n 
2 362 THR n 
2 363 SER n 
2 364 GLN n 
2 365 SER n 
2 366 TYR n 
2 367 THR n 
2 368 CYS n 
2 369 ASN n 
2 370 GLN n 
2 371 GLU n 
2 372 CYS n 
2 373 ASP n 
2 374 ASN n 
2 375 CYS n 
2 376 LEU n 
2 377 ASN n 
2 378 ALA n 
2 379 THR n 
2 380 LEU n 
2 381 SER n 
2 382 PHE n 
2 383 ASN n 
2 384 THR n 
2 385 ILE n 
2 386 LEU n 
2 387 ARG n 
2 388 LEU n 
2 389 SER n 
2 390 GLY n 
2 391 GLU n 
2 392 ARG n 
2 393 VAL n 
2 394 VAL n 
2 395 TYR n 
2 396 SER n 
2 397 VAL n 
2 398 TYR n 
2 399 SER n 
2 400 ALA n 
2 401 VAL n 
2 402 TYR n 
2 403 ALA n 
2 404 VAL n 
2 405 ALA n 
2 406 HIS n 
2 407 ALA n 
2 408 LEU n 
2 409 HIS n 
2 410 SER n 
2 411 LEU n 
2 412 LEU n 
2 413 GLY n 
2 414 CYS n 
2 415 ASP n 
2 416 LYS n 
2 417 SER n 
2 418 THR n 
2 419 CYS n 
2 420 THR n 
2 421 LYS n 
2 422 ARG n 
2 423 VAL n 
2 424 VAL n 
2 425 TYR n 
2 426 PRO n 
2 427 TRP n 
2 428 GLN n 
2 429 LEU n 
2 430 LEU n 
2 431 GLU n 
2 432 GLU n 
2 433 ILE n 
2 434 TRP n 
2 435 LYS n 
2 436 VAL n 
2 437 ASN n 
2 438 PHE n 
2 439 THR n 
2 440 LEU n 
2 441 LEU n 
2 442 ASP n 
2 443 HIS n 
2 444 GLN n 
2 445 ILE n 
2 446 PHE n 
2 447 PHE n 
2 448 ASP n 
2 449 PRO n 
2 450 GLN n 
2 451 GLY n 
2 452 ASP n 
2 453 VAL n 
2 454 ALA n 
2 455 LEU n 
2 456 HIS n 
2 457 LEU n 
2 458 GLU n 
2 459 ILE n 
2 460 VAL n 
2 461 GLN n 
2 462 TRP n 
2 463 GLN n 
2 464 TRP n 
2 465 ASP n 
2 466 ARG n 
2 467 SER n 
2 468 GLN n 
2 469 ASN n 
2 470 PRO n 
2 471 PHE n 
2 472 GLN n 
2 473 SER n 
2 474 VAL n 
2 475 ALA n 
2 476 SER n 
2 477 TYR n 
2 478 TYR n 
2 479 PRO n 
2 480 LEU n 
2 481 GLN n 
2 482 ARG n 
2 483 GLN n 
2 484 LEU n 
2 485 LYS n 
2 486 ASN n 
2 487 ILE n 
2 488 GLN n 
2 489 ASP n 
2 490 ILE n 
2 491 SER n 
2 492 TRP n 
2 493 HIS n 
2 494 THR n 
2 495 ILE n 
2 496 ASN n 
2 497 ASN n 
2 498 THR n 
2 499 ILE n 
2 500 PRO n 
2 501 MET n 
2 502 SER n 
2 503 MET n 
2 504 CYS n 
2 505 SER n 
2 506 LYS n 
2 507 ARG n 
2 508 CYS n 
2 509 GLN n 
2 510 SER n 
2 511 GLY n 
2 512 GLN n 
2 513 LYS n 
2 514 LYS n 
2 515 LYS n 
2 516 PRO n 
2 517 VAL n 
2 518 GLY n 
2 519 ILE n 
2 520 HIS n 
2 521 VAL n 
2 522 CYS n 
2 523 CYS n 
2 524 PHE n 
2 525 GLU n 
2 526 CYS n 
2 527 ILE n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 528 human ? 'TAS1R3, T1R3, TR3'        ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 527 human ? 'TAS1R2, GPR71, T1R2, TR2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
_pdbx_entity_branch_descriptor.ordinal           1 
_pdbx_entity_branch_descriptor.entity_id         3 
_pdbx_entity_branch_descriptor.descriptor        '[][b-D-Fruf1chloro6chloro]{[(2+1)][a-D-Galp4chloro]{}}' 
_pdbx_entity_branch_descriptor.type              LINUCS 
_pdbx_entity_branch_descriptor.program           PDB-CARE 
_pdbx_entity_branch_descriptor.program_version   ? 
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  3 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  RRJ 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          H1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  RRY 
_pdbx_entity_branch_link.atom_id_2                  O2 
_pdbx_entity_branch_link.leaving_atom_id_2          HO2 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE                                        ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE                                       ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE                                     ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'                                ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'           y CYSTEINE                                       ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'           y GLUTAMINE                                      ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'                                ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE                                        ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE                                      ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'           y ISOLEUCINE                                     ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE                                        ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                                         ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'           y METHIONINE                                     ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking'  . 2-acetamido-2-deoxy-beta-D-glucopyranose       
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'           y PHENYLALANINE                                  ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE                                        ? 'C5 H9 N O2'     115.130 
RRJ 'D-saccharide, alpha linking' . 4-chloro-4-deoxy-alpha-D-galactopyranose       ? 'C6 H11 Cl O5'   198.602 
RRY 'D-saccharide, beta linking'  . 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose ? 'C6 H10 Cl2 O4'  217.047 
SER 'L-peptide linking'           y SERINE                                         ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE                                      ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN                                     ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE                                       ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                                         ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -6  ?   ?   ?   B . n 
A 1 2   LYS 2   -5  ?   ?   ?   B . n 
A 1 3   THR 3   -4  ?   ?   ?   B . n 
A 1 4   ILE 4   -3  ?   ?   ?   B . n 
A 1 5   ILE 5   -2  ?   ?   ?   B . n 
A 1 6   ALA 6   -1  ?   ?   ?   B . n 
A 1 7   LEU 7   0   ?   ?   ?   B . n 
A 1 8   SER 8   1   ?   ?   ?   B . n 
A 1 9   TYR 9   2   ?   ?   ?   B . n 
A 1 10  ILE 10  3   ?   ?   ?   B . n 
A 1 11  PHE 11  4   ?   ?   ?   B . n 
A 1 12  CYS 12  5   ?   ?   ?   B . n 
A 1 13  LEU 13  6   ?   ?   ?   B . n 
A 1 14  VAL 14  7   ?   ?   ?   B . n 
A 1 15  PHE 15  8   ?   ?   ?   B . n 
A 1 16  ALA 16  9   ?   ?   ?   B . n 
A 1 17  ASP 17  10  ?   ?   ?   B . n 
A 1 18  TYR 18  11  ?   ?   ?   B . n 
A 1 19  LYS 19  12  ?   ?   ?   B . n 
A 1 20  ASP 20  13  ?   ?   ?   B . n 
A 1 21  ASP 21  14  ?   ?   ?   B . n 
A 1 22  ASP 22  15  ?   ?   ?   B . n 
A 1 23  ASP 23  16  ?   ?   ?   B . n 
A 1 24  LYS 24  17  ?   ?   ?   B . n 
A 1 25  ALA 25  18  ?   ?   ?   B . n 
A 1 26  ALA 26  19  ?   ?   ?   B . n 
A 1 27  ALA 27  20  ?   ?   ?   B . n 
A 1 28  ALA 28  21  ?   ?   ?   B . n 
A 1 29  PRO 29  22  ?   ?   ?   B . n 
A 1 30  LEU 30  23  23  LEU LEU B . n 
A 1 31  CYS 31  24  24  CYS CYS B . n 
A 1 32  LEU 32  25  25  LEU LEU B . n 
A 1 33  SER 33  26  26  SER SER B . n 
A 1 34  GLN 34  27  27  GLN GLN B . n 
A 1 35  GLN 35  28  28  GLN GLN B . n 
A 1 36  LEU 36  29  29  LEU LEU B . n 
A 1 37  ARG 37  30  30  ARG ARG B . n 
A 1 38  MET 38  31  31  MET MET B . n 
A 1 39  LYS 39  32  32  LYS LYS B . n 
A 1 40  GLY 40  33  33  GLY GLY B . n 
A 1 41  ASP 41  34  34  ASP ASP B . n 
A 1 42  TYR 42  35  35  TYR TYR B . n 
A 1 43  VAL 43  36  36  VAL VAL B . n 
A 1 44  LEU 44  37  37  LEU LEU B . n 
A 1 45  GLY 45  38  38  GLY GLY B . n 
A 1 46  GLY 46  39  39  GLY GLY B . n 
A 1 47  LEU 47  40  40  LEU LEU B . n 
A 1 48  PHE 48  41  41  PHE PHE B . n 
A 1 49  PRO 49  42  42  PRO PRO B . n 
A 1 50  LEU 50  43  43  LEU LEU B . n 
A 1 51  GLY 51  44  44  GLY GLY B . n 
A 1 52  GLU 52  45  45  GLU GLU B . n 
A 1 53  ALA 53  46  46  ALA ALA B . n 
A 1 54  GLU 54  47  ?   ?   ?   B . n 
A 1 55  GLU 55  48  ?   ?   ?   B . n 
A 1 56  ALA 56  49  ?   ?   ?   B . n 
A 1 57  GLY 57  50  ?   ?   ?   B . n 
A 1 58  LEU 58  51  ?   ?   ?   B . n 
A 1 59  ARG 59  52  ?   ?   ?   B . n 
A 1 60  SER 60  53  ?   ?   ?   B . n 
A 1 61  ARG 61  54  54  ARG ARG B . n 
A 1 62  THR 62  55  55  THR THR B . n 
A 1 63  ARG 63  56  56  ARG ARG B . n 
A 1 64  PRO 64  57  57  PRO PRO B . n 
A 1 65  SER 65  58  58  SER SER B . n 
A 1 66  SER 66  59  59  SER SER B . n 
A 1 67  PRO 67  60  60  PRO PRO B . n 
A 1 68  VAL 68  61  61  VAL VAL B . n 
A 1 69  CYS 69  62  62  CYS CYS B . n 
A 1 70  THR 70  63  63  THR THR B . n 
A 1 71  ARG 71  64  64  ARG ARG B . n 
A 1 72  PHE 72  65  65  PHE PHE B . n 
A 1 73  SER 73  66  66  SER SER B . n 
A 1 74  SER 74  67  67  SER SER B . n 
A 1 75  ASN 75  68  68  ASN ASN B . n 
A 1 76  GLY 76  69  69  GLY GLY B . n 
A 1 77  LEU 77  70  70  LEU LEU B . n 
A 1 78  LEU 78  71  71  LEU LEU B . n 
A 1 79  TRP 79  72  72  TRP TRP B . n 
A 1 80  ALA 80  73  73  ALA ALA B . n 
A 1 81  LEU 81  74  74  LEU LEU B . n 
A 1 82  ALA 82  75  75  ALA ALA B . n 
A 1 83  MET 83  76  76  MET MET B . n 
A 1 84  LYS 84  77  77  LYS LYS B . n 
A 1 85  MET 85  78  78  MET MET B . n 
A 1 86  ALA 86  79  79  ALA ALA B . n 
A 1 87  VAL 87  80  80  VAL VAL B . n 
A 1 88  GLU 88  81  81  GLU GLU B . n 
A 1 89  GLU 89  82  82  GLU GLU B . n 
A 1 90  ILE 90  83  83  ILE ILE B . n 
A 1 91  ASN 91  84  84  ASN ASN B . n 
A 1 92  ASN 92  85  85  ASN ASN B . n 
A 1 93  LYS 93  86  86  LYS LYS B . n 
A 1 94  SER 94  87  87  SER SER B . n 
A 1 95  ASP 95  88  88  ASP ASP B . n 
A 1 96  LEU 96  89  89  LEU LEU B . n 
A 1 97  LEU 97  90  90  LEU LEU B . n 
A 1 98  PRO 98  91  91  PRO PRO B . n 
A 1 99  GLY 99  92  92  GLY GLY B . n 
A 1 100 LEU 100 93  93  LEU LEU B . n 
A 1 101 ARG 101 94  94  ARG ARG B . n 
A 1 102 LEU 102 95  95  LEU LEU B . n 
A 1 103 GLY 103 96  96  GLY GLY B . n 
A 1 104 TYR 104 97  97  TYR TYR B . n 
A 1 105 ASP 105 98  98  ASP ASP B . n 
A 1 106 LEU 106 99  99  LEU LEU B . n 
A 1 107 PHE 107 100 100 PHE PHE B . n 
A 1 108 ASP 108 101 101 ASP ASP B . n 
A 1 109 THR 109 102 102 THR THR B . n 
A 1 110 CYS 110 103 103 CYS CYS B . n 
A 1 111 SER 111 104 104 SER SER B . n 
A 1 112 GLU 112 105 105 GLU GLU B . n 
A 1 113 PRO 113 106 106 PRO PRO B . n 
A 1 114 VAL 114 107 107 VAL VAL B . n 
A 1 115 VAL 115 108 108 VAL VAL B . n 
A 1 116 ALA 116 109 109 ALA ALA B . n 
A 1 117 MET 117 110 110 MET MET B . n 
A 1 118 LYS 118 111 111 LYS LYS B . n 
A 1 119 PRO 119 112 112 PRO PRO B . n 
A 1 120 SER 120 113 113 SER SER B . n 
A 1 121 LEU 121 114 114 LEU LEU B . n 
A 1 122 MET 122 115 115 MET MET B . n 
A 1 123 PHE 123 116 116 PHE PHE B . n 
A 1 124 LEU 124 117 117 LEU LEU B . n 
A 1 125 ALA 125 118 118 ALA ALA B . n 
A 1 126 LYS 126 119 119 LYS LYS B . n 
A 1 127 ALA 127 120 120 ALA ALA B . n 
A 1 128 GLY 128 121 121 GLY GLY B . n 
A 1 129 SER 129 122 122 SER SER B . n 
A 1 130 ARG 130 123 123 ARG ARG B . n 
A 1 131 ASP 131 124 124 ASP ASP B . n 
A 1 132 ILE 132 125 125 ILE ILE B . n 
A 1 133 ALA 133 126 126 ALA ALA B . n 
A 1 134 ALA 134 127 127 ALA ALA B . n 
A 1 135 TYR 135 128 128 TYR TYR B . n 
A 1 136 CYS 136 129 129 CYS CYS B . n 
A 1 137 ASN 137 130 130 ASN ASN B . n 
A 1 138 TYR 138 131 131 TYR TYR B . n 
A 1 139 THR 139 132 132 THR THR B . n 
A 1 140 GLN 140 133 133 GLN GLN B . n 
A 1 141 TYR 141 134 134 TYR TYR B . n 
A 1 142 GLN 142 135 135 GLN GLN B . n 
A 1 143 PRO 143 136 136 PRO PRO B . n 
A 1 144 ARG 144 137 137 ARG ARG B . n 
A 1 145 VAL 145 138 138 VAL VAL B . n 
A 1 146 LEU 146 139 139 LEU LEU B . n 
A 1 147 ALA 147 140 140 ALA ALA B . n 
A 1 148 VAL 148 141 141 VAL VAL B . n 
A 1 149 ILE 149 142 142 ILE ILE B . n 
A 1 150 GLY 150 143 143 GLY GLY B . n 
A 1 151 PRO 151 144 144 PRO PRO B . n 
A 1 152 HIS 152 145 145 HIS HIS B . n 
A 1 153 SER 153 146 146 SER SER B . n 
A 1 154 SER 154 147 147 SER SER B . n 
A 1 155 GLU 155 148 148 GLU GLU B . n 
A 1 156 LEU 156 149 149 LEU LEU B . n 
A 1 157 ALA 157 150 150 ALA ALA B . n 
A 1 158 MET 158 151 151 MET MET B . n 
A 1 159 VAL 159 152 152 VAL VAL B . n 
A 1 160 THR 160 153 153 THR THR B . n 
A 1 161 GLY 161 154 154 GLY GLY B . n 
A 1 162 LYS 162 155 155 LYS LYS B . n 
A 1 163 PHE 163 156 156 PHE PHE B . n 
A 1 164 PHE 164 157 157 PHE PHE B . n 
A 1 165 SER 165 158 158 SER SER B . n 
A 1 166 PHE 166 159 159 PHE PHE B . n 
A 1 167 PHE 167 160 160 PHE PHE B . n 
A 1 168 LEU 168 161 161 LEU LEU B . n 
A 1 169 MET 169 162 162 MET MET B . n 
A 1 170 PRO 170 163 163 PRO PRO B . n 
A 1 171 GLN 171 164 164 GLN GLN B . n 
A 1 172 VAL 172 165 165 VAL VAL B . n 
A 1 173 SER 173 166 166 SER SER B . n 
A 1 174 TYR 174 167 167 TYR TYR B . n 
A 1 175 GLY 175 168 168 GLY GLY B . n 
A 1 176 ALA 176 169 169 ALA ALA B . n 
A 1 177 SER 177 170 170 SER SER B . n 
A 1 178 MET 178 171 171 MET MET B . n 
A 1 179 GLU 179 172 172 GLU GLU B . n 
A 1 180 LEU 180 173 173 LEU LEU B . n 
A 1 181 LEU 181 174 174 LEU LEU B . n 
A 1 182 SER 182 175 175 SER SER B . n 
A 1 183 ALA 183 176 176 ALA ALA B . n 
A 1 184 ARG 184 177 177 ARG ARG B . n 
A 1 185 GLU 185 178 178 GLU GLU B . n 
A 1 186 THR 186 179 179 THR THR B . n 
A 1 187 PHE 187 180 180 PHE PHE B . n 
A 1 188 PRO 188 181 181 PRO PRO B . n 
A 1 189 SER 189 182 182 SER SER B . n 
A 1 190 PHE 190 183 183 PHE PHE B . n 
A 1 191 PHE 191 184 184 PHE PHE B . n 
A 1 192 ARG 192 185 185 ARG ARG B . n 
A 1 193 THR 193 186 186 THR THR B . n 
A 1 194 VAL 194 187 187 VAL VAL B . n 
A 1 195 PRO 195 188 188 PRO PRO B . n 
A 1 196 SER 196 189 189 SER SER B . n 
A 1 197 ASP 197 190 190 ASP ASP B . n 
A 1 198 ARG 198 191 191 ARG ARG B . n 
A 1 199 VAL 199 192 192 VAL VAL B . n 
A 1 200 GLN 200 193 193 GLN GLN B . n 
A 1 201 LEU 201 194 194 LEU LEU B . n 
A 1 202 THR 202 195 195 THR THR B . n 
A 1 203 ALA 203 196 196 ALA ALA B . n 
A 1 204 ALA 204 197 197 ALA ALA B . n 
A 1 205 ALA 205 198 198 ALA ALA B . n 
A 1 206 GLU 206 199 199 GLU GLU B . n 
A 1 207 LEU 207 200 200 LEU LEU B . n 
A 1 208 LEU 208 201 201 LEU LEU B . n 
A 1 209 GLN 209 202 202 GLN GLN B . n 
A 1 210 GLU 210 203 203 GLU GLU B . n 
A 1 211 PHE 211 204 204 PHE PHE B . n 
A 1 212 GLY 212 205 205 GLY GLY B . n 
A 1 213 TRP 213 206 206 TRP TRP B . n 
A 1 214 ASN 214 207 207 ASN ASN B . n 
A 1 215 TRP 215 208 208 TRP TRP B . n 
A 1 216 VAL 216 209 209 VAL VAL B . n 
A 1 217 ALA 217 210 210 ALA ALA B . n 
A 1 218 ALA 218 211 211 ALA ALA B . n 
A 1 219 LEU 219 212 212 LEU LEU B . n 
A 1 220 GLY 220 213 213 GLY GLY B . n 
A 1 221 SER 221 214 214 SER SER B . n 
A 1 222 ASP 222 215 215 ASP ASP B . n 
A 1 223 ASP 223 216 216 ASP ASP B . n 
A 1 224 GLU 224 217 217 GLU GLU B . n 
A 1 225 TYR 225 218 218 TYR TYR B . n 
A 1 226 GLY 226 219 219 GLY GLY B . n 
A 1 227 ARG 227 220 220 ARG ARG B . n 
A 1 228 GLN 228 221 221 GLN GLN B . n 
A 1 229 GLY 229 222 222 GLY GLY B . n 
A 1 230 LEU 230 223 223 LEU LEU B . n 
A 1 231 SER 231 224 224 SER SER B . n 
A 1 232 ILE 232 225 225 ILE ILE B . n 
A 1 233 PHE 233 226 226 PHE PHE B . n 
A 1 234 SER 234 227 227 SER SER B . n 
A 1 235 ALA 235 228 228 ALA ALA B . n 
A 1 236 LEU 236 229 229 LEU LEU B . n 
A 1 237 ALA 237 230 230 ALA ALA B . n 
A 1 238 ALA 238 231 231 ALA ALA B . n 
A 1 239 ALA 239 232 232 ALA ALA B . n 
A 1 240 ARG 240 233 233 ARG ARG B . n 
A 1 241 GLY 241 234 234 GLY GLY B . n 
A 1 242 ILE 242 235 235 ILE ILE B . n 
A 1 243 CYS 243 236 236 CYS CYS B . n 
A 1 244 ILE 244 237 237 ILE ILE B . n 
A 1 245 ALA 245 238 238 ALA ALA B . n 
A 1 246 HIS 246 239 239 HIS HIS B . n 
A 1 247 GLU 247 240 240 GLU GLU B . n 
A 1 248 GLY 248 241 241 GLY GLY B . n 
A 1 249 LEU 249 242 242 LEU LEU B . n 
A 1 250 VAL 250 243 243 VAL VAL B . n 
A 1 251 PRO 251 244 244 PRO PRO B . n 
A 1 252 LEU 252 245 245 LEU LEU B . n 
A 1 253 PRO 253 246 246 PRO PRO B . n 
A 1 254 ARG 254 247 ?   ?   ?   B . n 
A 1 255 ALA 255 248 ?   ?   ?   B . n 
A 1 256 ASP 256 249 ?   ?   ?   B . n 
A 1 257 ASP 257 250 ?   ?   ?   B . n 
A 1 258 SER 258 251 ?   ?   ?   B . n 
A 1 259 ARG 259 252 ?   ?   ?   B . n 
A 1 260 LEU 260 253 ?   ?   ?   B . n 
A 1 261 GLY 261 254 ?   ?   ?   B . n 
A 1 262 LYS 262 255 255 LYS LYS B . n 
A 1 263 VAL 263 256 256 VAL VAL B . n 
A 1 264 GLN 264 257 257 GLN GLN B . n 
A 1 265 ASP 265 258 258 ASP ASP B . n 
A 1 266 VAL 266 259 259 VAL VAL B . n 
A 1 267 LEU 267 260 260 LEU LEU B . n 
A 1 268 HIS 268 261 261 HIS HIS B . n 
A 1 269 GLN 269 262 262 GLN GLN B . n 
A 1 270 VAL 270 263 263 VAL VAL B . n 
A 1 271 ASN 271 264 264 ASN ASN B . n 
A 1 272 GLN 272 265 265 GLN GLN B . n 
A 1 273 SER 273 266 266 SER SER B . n 
A 1 274 SER 274 267 267 SER SER B . n 
A 1 275 VAL 275 268 268 VAL VAL B . n 
A 1 276 GLN 276 269 269 GLN GLN B . n 
A 1 277 VAL 277 270 270 VAL VAL B . n 
A 1 278 VAL 278 271 271 VAL VAL B . n 
A 1 279 LEU 279 272 272 LEU LEU B . n 
A 1 280 LEU 280 273 273 LEU LEU B . n 
A 1 281 PHE 281 274 274 PHE PHE B . n 
A 1 282 ALA 282 275 275 ALA ALA B . n 
A 1 283 SER 283 276 276 SER SER B . n 
A 1 284 VAL 284 277 277 VAL VAL B . n 
A 1 285 HIS 285 278 278 HIS HIS B . n 
A 1 286 ALA 286 279 279 ALA ALA B . n 
A 1 287 ALA 287 280 280 ALA ALA B . n 
A 1 288 HIS 288 281 281 HIS HIS B . n 
A 1 289 ALA 289 282 282 ALA ALA B . n 
A 1 290 LEU 290 283 283 LEU LEU B . n 
A 1 291 PHE 291 284 284 PHE PHE B . n 
A 1 292 ASN 292 285 285 ASN ASN B . n 
A 1 293 TYR 293 286 286 TYR TYR B . n 
A 1 294 SER 294 287 287 SER SER B . n 
A 1 295 ILE 295 288 288 ILE ILE B . n 
A 1 296 SER 296 289 289 SER SER B . n 
A 1 297 SER 297 290 290 SER SER B . n 
A 1 298 ARG 298 291 291 ARG ARG B . n 
A 1 299 LEU 299 292 292 LEU LEU B . n 
A 1 300 SER 300 293 293 SER SER B . n 
A 1 301 PRO 301 294 294 PRO PRO B . n 
A 1 302 LYS 302 295 295 LYS LYS B . n 
A 1 303 VAL 303 296 296 VAL VAL B . n 
A 1 304 TRP 304 297 297 TRP TRP B . n 
A 1 305 VAL 305 298 298 VAL VAL B . n 
A 1 306 ALA 306 299 299 ALA ALA B . n 
A 1 307 SER 307 300 300 SER SER B . n 
A 1 308 GLU 308 301 301 GLU GLU B . n 
A 1 309 ALA 309 302 302 ALA ALA B . n 
A 1 310 TRP 310 303 303 TRP TRP B . n 
A 1 311 LEU 311 304 304 LEU LEU B . n 
A 1 312 THR 312 305 305 THR THR B . n 
A 1 313 SER 313 306 306 SER SER B . n 
A 1 314 ASP 314 307 307 ASP ASP B . n 
A 1 315 LEU 315 308 308 LEU LEU B . n 
A 1 316 VAL 316 309 309 VAL VAL B . n 
A 1 317 MET 317 310 310 MET MET B . n 
A 1 318 GLY 318 311 311 GLY GLY B . n 
A 1 319 LEU 319 312 312 LEU LEU B . n 
A 1 320 PRO 320 313 313 PRO PRO B . n 
A 1 321 GLY 321 314 314 GLY GLY B . n 
A 1 322 MET 322 315 315 MET MET B . n 
A 1 323 ALA 323 316 316 ALA ALA B . n 
A 1 324 GLN 324 317 317 GLN GLN B . n 
A 1 325 MET 325 318 318 MET MET B . n 
A 1 326 GLY 326 319 319 GLY GLY B . n 
A 1 327 THR 327 320 320 THR THR B . n 
A 1 328 VAL 328 321 321 VAL VAL B . n 
A 1 329 LEU 329 322 322 LEU LEU B . n 
A 1 330 GLY 330 323 323 GLY GLY B . n 
A 1 331 PHE 331 324 324 PHE PHE B . n 
A 1 332 LEU 332 325 325 LEU LEU B . n 
A 1 333 GLN 333 326 326 GLN GLN B . n 
A 1 334 ARG 334 327 327 ARG ARG B . n 
A 1 335 GLY 335 328 328 GLY GLY B . n 
A 1 336 ALA 336 329 329 ALA ALA B . n 
A 1 337 GLN 337 330 330 GLN GLN B . n 
A 1 338 LEU 338 331 331 LEU LEU B . n 
A 1 339 HIS 339 332 332 HIS HIS B . n 
A 1 340 GLU 340 333 333 GLU GLU B . n 
A 1 341 PHE 341 334 334 PHE PHE B . n 
A 1 342 PRO 342 335 335 PRO PRO B . n 
A 1 343 GLN 343 336 336 GLN GLN B . n 
A 1 344 TYR 344 337 337 TYR TYR B . n 
A 1 345 VAL 345 338 338 VAL VAL B . n 
A 1 346 LYS 346 339 339 LYS LYS B . n 
A 1 347 THR 347 340 340 THR THR B . n 
A 1 348 HIS 348 341 341 HIS HIS B . n 
A 1 349 LEU 349 342 342 LEU LEU B . n 
A 1 350 ALA 350 343 343 ALA ALA B . n 
A 1 351 LEU 351 344 344 LEU LEU B . n 
A 1 352 ALA 352 345 345 ALA ALA B . n 
A 1 353 THR 353 346 346 THR THR B . n 
A 1 354 ASP 354 347 347 ASP ASP B . n 
A 1 355 PRO 355 348 348 PRO PRO B . n 
A 1 356 ALA 356 349 349 ALA ALA B . n 
A 1 357 PHE 357 350 350 PHE PHE B . n 
A 1 358 CYS 358 351 351 CYS CYS B . n 
A 1 359 SER 359 352 352 SER SER B . n 
A 1 360 ALA 360 353 353 ALA ALA B . n 
A 1 361 LEU 361 354 354 LEU LEU B . n 
A 1 362 GLY 362 355 ?   ?   ?   B . n 
A 1 363 GLU 363 356 ?   ?   ?   B . n 
A 1 364 ARG 364 357 ?   ?   ?   B . n 
A 1 365 GLU 365 358 ?   ?   ?   B . n 
A 1 366 GLN 366 359 ?   ?   ?   B . n 
A 1 367 GLY 367 360 ?   ?   ?   B . n 
A 1 368 LEU 368 361 ?   ?   ?   B . n 
A 1 369 GLU 369 362 ?   ?   ?   B . n 
A 1 370 GLU 370 363 ?   ?   ?   B . n 
A 1 371 ASP 371 364 ?   ?   ?   B . n 
A 1 372 VAL 372 365 ?   ?   ?   B . n 
A 1 373 VAL 373 366 ?   ?   ?   B . n 
A 1 374 GLY 374 367 ?   ?   ?   B . n 
A 1 375 GLN 375 368 368 GLN GLN B . n 
A 1 376 ARG 376 369 369 ARG ARG B . n 
A 1 377 CYS 377 370 370 CYS CYS B . n 
A 1 378 PRO 378 371 371 PRO PRO B . n 
A 1 379 GLN 379 372 372 GLN GLN B . n 
A 1 380 CYS 380 373 373 CYS CYS B . n 
A 1 381 ASP 381 374 374 ASP ASP B . n 
A 1 382 CYS 382 375 375 CYS CYS B . n 
A 1 383 ILE 383 376 376 ILE ILE B . n 
A 1 384 THR 384 377 377 THR THR B . n 
A 1 385 LEU 385 378 378 LEU LEU B . n 
A 1 386 GLN 386 379 379 GLN GLN B . n 
A 1 387 ASN 387 380 380 ASN ASN B . n 
A 1 388 VAL 388 381 381 VAL VAL B . n 
A 1 389 SER 389 382 382 SER SER B . n 
A 1 390 ALA 390 383 383 ALA ALA B . n 
A 1 391 GLY 391 384 384 GLY GLY B . n 
A 1 392 LEU 392 385 385 LEU LEU B . n 
A 1 393 ASN 393 386 386 ASN ASN B . n 
A 1 394 HIS 394 387 387 HIS HIS B . n 
A 1 395 HIS 395 388 388 HIS HIS B . n 
A 1 396 GLN 396 389 389 GLN GLN B . n 
A 1 397 THR 397 390 390 THR THR B . n 
A 1 398 PHE 398 391 391 PHE PHE B . n 
A 1 399 SER 399 392 392 SER SER B . n 
A 1 400 VAL 400 393 393 VAL VAL B . n 
A 1 401 TYR 401 394 394 TYR TYR B . n 
A 1 402 ALA 402 395 395 ALA ALA B . n 
A 1 403 ALA 403 396 396 ALA ALA B . n 
A 1 404 VAL 404 397 397 VAL VAL B . n 
A 1 405 TYR 405 398 398 TYR TYR B . n 
A 1 406 SER 406 399 399 SER SER B . n 
A 1 407 VAL 407 400 400 VAL VAL B . n 
A 1 408 ALA 408 401 401 ALA ALA B . n 
A 1 409 GLN 409 402 402 GLN GLN B . n 
A 1 410 ALA 410 403 403 ALA ALA B . n 
A 1 411 LEU 411 404 404 LEU LEU B . n 
A 1 412 HIS 412 405 405 HIS HIS B . n 
A 1 413 ASN 413 406 406 ASN ASN B . n 
A 1 414 THR 414 407 407 THR THR B . n 
A 1 415 LEU 415 408 408 LEU LEU B . n 
A 1 416 GLN 416 409 409 GLN GLN B . n 
A 1 417 CYS 417 410 410 CYS CYS B . n 
A 1 418 ASN 418 411 411 ASN ASN B . n 
A 1 419 ALA 419 412 412 ALA ALA B . n 
A 1 420 SER 420 413 413 SER SER B . n 
A 1 421 GLY 421 414 414 GLY GLY B . n 
A 1 422 CYS 422 415 415 CYS CYS B . n 
A 1 423 PRO 423 416 416 PRO PRO B . n 
A 1 424 ALA 424 417 417 ALA ALA B . n 
A 1 425 GLN 425 418 418 GLN GLN B . n 
A 1 426 ASP 426 419 419 ASP ASP B . n 
A 1 427 PRO 427 420 420 PRO PRO B . n 
A 1 428 VAL 428 421 421 VAL VAL B . n 
A 1 429 LYS 429 422 422 LYS LYS B . n 
A 1 430 PRO 430 423 423 PRO PRO B . n 
A 1 431 TRP 431 424 424 TRP TRP B . n 
A 1 432 GLN 432 425 425 GLN GLN B . n 
A 1 433 LEU 433 426 426 LEU LEU B . n 
A 1 434 LEU 434 427 427 LEU LEU B . n 
A 1 435 GLU 435 428 428 GLU GLU B . n 
A 1 436 ASN 436 429 429 ASN ASN B . n 
A 1 437 MET 437 430 430 MET MET B . n 
A 1 438 TYR 438 431 431 TYR TYR B . n 
A 1 439 ASN 439 432 432 ASN ASN B . n 
A 1 440 LEU 440 433 433 LEU LEU B . n 
A 1 441 THR 441 434 434 THR THR B . n 
A 1 442 PHE 442 435 435 PHE PHE B . n 
A 1 443 HIS 443 436 436 HIS HIS B . n 
A 1 444 VAL 444 437 437 VAL VAL B . n 
A 1 445 GLY 445 438 438 GLY GLY B . n 
A 1 446 GLY 446 439 439 GLY GLY B . n 
A 1 447 LEU 447 440 440 LEU LEU B . n 
A 1 448 PRO 448 441 441 PRO PRO B . n 
A 1 449 LEU 449 442 442 LEU LEU B . n 
A 1 450 ARG 450 443 443 ARG ARG B . n 
A 1 451 PHE 451 444 444 PHE PHE B . n 
A 1 452 ASP 452 445 445 ASP ASP B . n 
A 1 453 SER 453 446 446 SER SER B . n 
A 1 454 SER 454 447 447 SER SER B . n 
A 1 455 GLY 455 448 448 GLY GLY B . n 
A 1 456 ASN 456 449 449 ASN ASN B . n 
A 1 457 VAL 457 450 450 VAL VAL B . n 
A 1 458 ASP 458 451 451 ASP ASP B . n 
A 1 459 MET 459 452 452 MET MET B . n 
A 1 460 GLU 460 453 453 GLU GLU B . n 
A 1 461 TYR 461 454 454 TYR TYR B . n 
A 1 462 ASP 462 455 455 ASP ASP B . n 
A 1 463 LEU 463 456 456 LEU LEU B . n 
A 1 464 LYS 464 457 457 LYS LYS B . n 
A 1 465 LEU 465 458 458 LEU LEU B . n 
A 1 466 TRP 466 459 459 TRP TRP B . n 
A 1 467 VAL 467 460 460 VAL VAL B . n 
A 1 468 TRP 468 461 461 TRP TRP B . n 
A 1 469 GLN 469 462 462 GLN GLN B . n 
A 1 470 GLY 470 463 463 GLY GLY B . n 
A 1 471 SER 471 464 464 SER SER B . n 
A 1 472 VAL 472 465 465 VAL VAL B . n 
A 1 473 PRO 473 466 466 PRO PRO B . n 
A 1 474 ARG 474 467 467 ARG ARG B . n 
A 1 475 LEU 475 468 468 LEU LEU B . n 
A 1 476 HIS 476 469 469 HIS HIS B . n 
A 1 477 ASP 477 470 470 ASP ASP B . n 
A 1 478 VAL 478 471 471 VAL VAL B . n 
A 1 479 GLY 479 472 472 GLY GLY B . n 
A 1 480 ARG 480 473 473 ARG ARG B . n 
A 1 481 PHE 481 474 474 PHE PHE B . n 
A 1 482 ASN 482 475 475 ASN ASN B . n 
A 1 483 GLY 483 476 476 GLY GLY B . n 
A 1 484 SER 484 477 477 SER SER B . n 
A 1 485 LEU 485 478 478 LEU LEU B . n 
A 1 486 ARG 486 479 479 ARG ARG B . n 
A 1 487 THR 487 480 480 THR THR B . n 
A 1 488 GLU 488 481 481 GLU GLU B . n 
A 1 489 ARG 489 482 482 ARG ARG B . n 
A 1 490 LEU 490 483 483 LEU LEU B . n 
A 1 491 LYS 491 484 484 LYS LYS B . n 
A 1 492 ILE 492 485 485 ILE ILE B . n 
A 1 493 ARG 493 486 486 ARG ARG B . n 
A 1 494 TRP 494 487 487 TRP TRP B . n 
A 1 495 HIS 495 488 488 HIS HIS B . n 
A 1 496 THR 496 489 489 THR THR B . n 
A 1 497 SER 497 490 490 SER SER B . n 
A 1 498 ASP 498 491 491 ASP ASP B . n 
A 1 499 ASN 499 492 492 ASN ASN B . n 
A 1 500 GLN 500 493 493 GLN GLN B . n 
A 1 501 LYS 501 494 494 LYS LYS B . n 
A 1 502 PRO 502 495 495 PRO PRO B . n 
A 1 503 VAL 503 496 496 VAL VAL B . n 
A 1 504 SER 504 497 497 SER SER B . n 
A 1 505 ARG 505 498 498 ARG ARG B . n 
A 1 506 CYS 506 499 499 CYS CYS B . n 
A 1 507 SER 507 500 500 SER SER B . n 
A 1 508 ARG 508 501 501 ARG ARG B . n 
A 1 509 GLN 509 502 502 GLN GLN B . n 
A 1 510 CYS 510 503 503 CYS CYS B . n 
A 1 511 GLN 511 504 ?   ?   ?   B . n 
A 1 512 GLU 512 505 ?   ?   ?   B . n 
A 1 513 GLY 513 506 ?   ?   ?   B . n 
A 1 514 GLN 514 507 ?   ?   ?   B . n 
A 1 515 VAL 515 508 508 VAL VAL B . n 
A 1 516 ARG 516 509 509 ARG ARG B . n 
A 1 517 ARG 517 510 510 ARG ARG B . n 
A 1 518 VAL 518 511 511 VAL VAL B . n 
A 1 519 LYS 519 512 512 LYS LYS B . n 
A 1 520 GLY 520 513 513 GLY GLY B . n 
A 1 521 PHE 521 514 514 PHE PHE B . n 
A 1 522 HIS 522 515 515 HIS HIS B . n 
A 1 523 SER 523 516 516 SER SER B . n 
A 1 524 CYS 524 517 517 CYS CYS B . n 
A 1 525 CYS 525 518 518 CYS CYS B . n 
A 1 526 TYR 526 519 519 TYR TYR B . n 
A 1 527 ASP 527 520 520 ASP ASP B . n 
A 1 528 CYS 528 521 521 CYS CYS B . n 
B 2 1   MET 1   -8  ?   ?   ?   A . n 
B 2 2   LYS 2   -7  ?   ?   ?   A . n 
B 2 3   THR 3   -6  ?   ?   ?   A . n 
B 2 4   ILE 4   -5  ?   ?   ?   A . n 
B 2 5   ILE 5   -4  ?   ?   ?   A . n 
B 2 6   ALA 6   -3  ?   ?   ?   A . n 
B 2 7   LEU 7   -2  ?   ?   ?   A . n 
B 2 8   SER 8   -1  ?   ?   ?   A . n 
B 2 9   TYR 9   0   ?   ?   ?   A . n 
B 2 10  ILE 10  1   ?   ?   ?   A . n 
B 2 11  PHE 11  2   ?   ?   ?   A . n 
B 2 12  CYS 12  3   ?   ?   ?   A . n 
B 2 13  LEU 13  4   ?   ?   ?   A . n 
B 2 14  VAL 14  5   ?   ?   ?   A . n 
B 2 15  PHE 15  6   ?   ?   ?   A . n 
B 2 16  ALA 16  7   ?   ?   ?   A . n 
B 2 17  TYR 17  8   ?   ?   ?   A . n 
B 2 18  PRO 18  9   ?   ?   ?   A . n 
B 2 19  TYR 19  10  ?   ?   ?   A . n 
B 2 20  ASP 20  11  ?   ?   ?   A . n 
B 2 21  VAL 21  12  ?   ?   ?   A . n 
B 2 22  PRO 22  13  ?   ?   ?   A . n 
B 2 23  ASP 23  14  ?   ?   ?   A . n 
B 2 24  TYR 24  15  ?   ?   ?   A . n 
B 2 25  ALA 25  16  ?   ?   ?   A . n 
B 2 26  ALA 26  17  ?   ?   ?   A . n 
B 2 27  ALA 27  18  ?   ?   ?   A . n 
B 2 28  ALA 28  19  ?   ?   ?   A . n 
B 2 29  GLU 29  20  ?   ?   ?   A . n 
B 2 30  PRO 30  21  ?   ?   ?   A . n 
B 2 31  ALA 31  22  ?   ?   ?   A . n 
B 2 32  GLU 32  23  ?   ?   ?   A . n 
B 2 33  ASN 33  24  ?   ?   ?   A . n 
B 2 34  SER 34  25  25  SER SER A . n 
B 2 35  ASP 35  26  26  ASP ASP A . n 
B 2 36  PHE 36  27  27  PHE PHE A . n 
B 2 37  TYR 37  28  28  TYR TYR A . n 
B 2 38  LEU 38  29  29  LEU LEU A . n 
B 2 39  PRO 39  30  30  PRO PRO A . n 
B 2 40  GLY 40  31  31  GLY GLY A . n 
B 2 41  ASP 41  32  32  ASP ASP A . n 
B 2 42  TYR 42  33  33  TYR TYR A . n 
B 2 43  LEU 43  34  34  LEU LEU A . n 
B 2 44  LEU 44  35  35  LEU LEU A . n 
B 2 45  GLY 45  36  36  GLY GLY A . n 
B 2 46  GLY 46  37  37  GLY GLY A . n 
B 2 47  LEU 47  38  38  LEU LEU A . n 
B 2 48  PHE 48  39  39  PHE PHE A . n 
B 2 49  SER 49  40  40  SER SER A . n 
B 2 50  LEU 50  41  41  LEU LEU A . n 
B 2 51  HIS 51  42  42  HIS HIS A . n 
B 2 52  ALA 52  43  43  ALA ALA A . n 
B 2 53  ASN 53  44  44  ASN ASN A . n 
B 2 54  MET 54  45  45  MET MET A . n 
B 2 55  LYS 55  46  46  LYS LYS A . n 
B 2 56  GLY 56  47  ?   ?   ?   A . n 
B 2 57  ILE 57  48  ?   ?   ?   A . n 
B 2 58  VAL 58  49  ?   ?   ?   A . n 
B 2 59  HIS 59  50  ?   ?   ?   A . n 
B 2 60  LEU 60  51  ?   ?   ?   A . n 
B 2 61  ASN 61  52  52  ASN ASN A . n 
B 2 62  PHE 62  53  53  PHE PHE A . n 
B 2 63  LEU 63  54  54  LEU LEU A . n 
B 2 64  GLN 64  55  55  GLN GLN A . n 
B 2 65  VAL 65  56  56  VAL VAL A . n 
B 2 66  PRO 66  57  57  PRO PRO A . n 
B 2 67  MET 67  58  58  MET MET A . n 
B 2 68  CYS 68  59  59  CYS CYS A . n 
B 2 69  LYS 69  60  60  LYS LYS A . n 
B 2 70  GLU 70  61  61  GLU GLU A . n 
B 2 71  TYR 71  62  62  TYR TYR A . n 
B 2 72  GLU 72  63  63  GLU GLU A . n 
B 2 73  VAL 73  64  64  VAL VAL A . n 
B 2 74  LYS 74  65  65  LYS LYS A . n 
B 2 75  VAL 75  66  66  VAL VAL A . n 
B 2 76  ILE 76  67  67  ILE ILE A . n 
B 2 77  GLY 77  68  68  GLY GLY A . n 
B 2 78  TYR 78  69  69  TYR TYR A . n 
B 2 79  ASN 79  70  70  ASN ASN A . n 
B 2 80  LEU 80  71  71  LEU LEU A . n 
B 2 81  MET 81  72  72  MET MET A . n 
B 2 82  GLN 82  73  73  GLN GLN A . n 
B 2 83  ALA 83  74  74  ALA ALA A . n 
B 2 84  MET 84  75  75  MET MET A . n 
B 2 85  ARG 85  76  76  ARG ARG A . n 
B 2 86  PHE 86  77  77  PHE PHE A . n 
B 2 87  ALA 87  78  78  ALA ALA A . n 
B 2 88  VAL 88  79  79  VAL VAL A . n 
B 2 89  GLU 89  80  80  GLU GLU A . n 
B 2 90  GLU 90  81  81  GLU GLU A . n 
B 2 91  ILE 91  82  82  ILE ILE A . n 
B 2 92  ASN 92  83  83  ASN ASN A . n 
B 2 93  ASN 93  84  84  ASN ASN A . n 
B 2 94  ASP 94  85  85  ASP ASP A . n 
B 2 95  SER 95  86  86  SER SER A . n 
B 2 96  SER 96  87  87  SER SER A . n 
B 2 97  LEU 97  88  88  LEU LEU A . n 
B 2 98  LEU 98  89  89  LEU LEU A . n 
B 2 99  PRO 99  90  90  PRO PRO A . n 
B 2 100 GLY 100 91  91  GLY GLY A . n 
B 2 101 VAL 101 92  92  VAL VAL A . n 
B 2 102 LEU 102 93  93  LEU LEU A . n 
B 2 103 LEU 103 94  94  LEU LEU A . n 
B 2 104 GLY 104 95  95  GLY GLY A . n 
B 2 105 TYR 105 96  96  TYR TYR A . n 
B 2 106 GLU 106 97  97  GLU GLU A . n 
B 2 107 ILE 107 98  98  ILE ILE A . n 
B 2 108 VAL 108 99  99  VAL VAL A . n 
B 2 109 ASP 109 100 100 ASP ASP A . n 
B 2 110 VAL 110 101 101 VAL VAL A . n 
B 2 111 CYS 111 102 102 CYS CYS A . n 
B 2 112 TYR 112 103 103 TYR TYR A . n 
B 2 113 ILE 113 104 104 ILE ILE A . n 
B 2 114 SER 114 105 105 SER SER A . n 
B 2 115 ASN 115 106 106 ASN ASN A . n 
B 2 116 ASN 116 107 107 ASN ASN A . n 
B 2 117 VAL 117 108 108 VAL VAL A . n 
B 2 118 GLN 118 109 109 GLN GLN A . n 
B 2 119 PRO 119 110 110 PRO PRO A . n 
B 2 120 VAL 120 111 111 VAL VAL A . n 
B 2 121 LEU 121 112 112 LEU LEU A . n 
B 2 122 TYR 122 113 113 TYR TYR A . n 
B 2 123 PHE 123 114 114 PHE PHE A . n 
B 2 124 LEU 124 115 115 LEU LEU A . n 
B 2 125 ALA 125 116 116 ALA ALA A . n 
B 2 126 HIS 126 117 117 HIS HIS A . n 
B 2 127 GLU 127 118 118 GLU GLU A . n 
B 2 128 ASP 128 119 119 ASP ASP A . n 
B 2 129 ASN 129 120 120 ASN ASN A . n 
B 2 130 LEU 130 121 121 LEU LEU A . n 
B 2 131 LEU 131 122 122 LEU LEU A . n 
B 2 132 PRO 132 123 123 PRO PRO A . n 
B 2 133 ILE 133 124 124 ILE ILE A . n 
B 2 134 GLN 134 125 125 GLN GLN A . n 
B 2 135 GLU 135 126 126 GLU GLU A . n 
B 2 136 ASP 136 127 127 ASP ASP A . n 
B 2 137 TYR 137 128 128 TYR TYR A . n 
B 2 138 SER 138 129 129 SER SER A . n 
B 2 139 ASN 139 130 130 ASN ASN A . n 
B 2 140 TYR 140 131 131 TYR TYR A . n 
B 2 141 ILE 141 132 132 ILE ILE A . n 
B 2 142 SER 142 133 133 SER SER A . n 
B 2 143 ARG 143 134 134 ARG ARG A . n 
B 2 144 VAL 144 135 135 VAL VAL A . n 
B 2 145 VAL 145 136 136 VAL VAL A . n 
B 2 146 ALA 146 137 137 ALA ALA A . n 
B 2 147 VAL 147 138 138 VAL VAL A . n 
B 2 148 ILE 148 139 139 ILE ILE A . n 
B 2 149 GLY 149 140 140 GLY GLY A . n 
B 2 150 PRO 150 141 141 PRO PRO A . n 
B 2 151 ASP 151 142 142 ASP ASP A . n 
B 2 152 ASN 152 143 143 ASN ASN A . n 
B 2 153 SER 153 144 144 SER SER A . n 
B 2 154 GLU 154 145 145 GLU GLU A . n 
B 2 155 SER 155 146 146 SER SER A . n 
B 2 156 VAL 156 147 147 VAL VAL A . n 
B 2 157 MET 157 148 148 MET MET A . n 
B 2 158 THR 158 149 149 THR THR A . n 
B 2 159 VAL 159 150 150 VAL VAL A . n 
B 2 160 ALA 160 151 151 ALA ALA A . n 
B 2 161 ASN 161 152 152 ASN ASN A . n 
B 2 162 PHE 162 153 153 PHE PHE A . n 
B 2 163 LEU 163 154 154 LEU LEU A . n 
B 2 164 SER 164 155 155 SER SER A . n 
B 2 165 LEU 165 156 156 LEU LEU A . n 
B 2 166 PHE 166 157 157 PHE PHE A . n 
B 2 167 LEU 167 158 158 LEU LEU A . n 
B 2 168 LEU 168 159 159 LEU LEU A . n 
B 2 169 PRO 169 160 160 PRO PRO A . n 
B 2 170 GLN 170 161 161 GLN GLN A . n 
B 2 171 ILE 171 162 162 ILE ILE A . n 
B 2 172 THR 172 163 163 THR THR A . n 
B 2 173 TYR 173 164 164 TYR TYR A . n 
B 2 174 SER 174 165 165 SER SER A . n 
B 2 175 ALA 175 166 166 ALA ALA A . n 
B 2 176 ILE 176 167 167 ILE ILE A . n 
B 2 177 SER 177 168 168 SER SER A . n 
B 2 178 ASP 178 169 169 ASP ASP A . n 
B 2 179 GLU 179 170 170 GLU GLU A . n 
B 2 180 LEU 180 171 171 LEU LEU A . n 
B 2 181 ARG 181 172 172 ARG ARG A . n 
B 2 182 ASP 182 173 173 ASP ASP A . n 
B 2 183 LYS 183 174 174 LYS LYS A . n 
B 2 184 VAL 184 175 175 VAL VAL A . n 
B 2 185 ARG 185 176 176 ARG ARG A . n 
B 2 186 PHE 186 177 177 PHE PHE A . n 
B 2 187 PRO 187 178 178 PRO PRO A . n 
B 2 188 ALA 188 179 179 ALA ALA A . n 
B 2 189 LEU 189 180 180 LEU LEU A . n 
B 2 190 LEU 190 181 181 LEU LEU A . n 
B 2 191 ARG 191 182 182 ARG ARG A . n 
B 2 192 THR 192 183 183 THR THR A . n 
B 2 193 THR 193 184 184 THR THR A . n 
B 2 194 PRO 194 185 185 PRO PRO A . n 
B 2 195 SER 195 186 186 SER SER A . n 
B 2 196 ALA 196 187 187 ALA ALA A . n 
B 2 197 ASP 197 188 188 ASP ASP A . n 
B 2 198 HIS 198 189 189 HIS HIS A . n 
B 2 199 HIS 199 190 190 HIS HIS A . n 
B 2 200 ILE 200 191 191 ILE ILE A . n 
B 2 201 GLU 201 192 192 GLU GLU A . n 
B 2 202 ALA 202 193 193 ALA ALA A . n 
B 2 203 MET 203 194 194 MET MET A . n 
B 2 204 VAL 204 195 195 VAL VAL A . n 
B 2 205 GLN 205 196 196 GLN GLN A . n 
B 2 206 LEU 206 197 197 LEU LEU A . n 
B 2 207 MET 207 198 198 MET MET A . n 
B 2 208 LEU 208 199 199 LEU LEU A . n 
B 2 209 HIS 209 200 200 HIS HIS A . n 
B 2 210 PHE 210 201 201 PHE PHE A . n 
B 2 211 ARG 211 202 202 ARG ARG A . n 
B 2 212 TRP 212 203 203 TRP TRP A . n 
B 2 213 ASN 213 204 204 ASN ASN A . n 
B 2 214 TRP 214 205 205 TRP TRP A . n 
B 2 215 ILE 215 206 206 ILE ILE A . n 
B 2 216 ILE 216 207 207 ILE ILE A . n 
B 2 217 VAL 217 208 208 VAL VAL A . n 
B 2 218 LEU 218 209 209 LEU LEU A . n 
B 2 219 VAL 219 210 210 VAL VAL A . n 
B 2 220 SER 220 211 211 SER SER A . n 
B 2 221 SER 221 212 212 SER SER A . n 
B 2 222 ASP 222 213 213 ASP ASP A . n 
B 2 223 THR 223 214 214 THR THR A . n 
B 2 224 TYR 224 215 215 TYR TYR A . n 
B 2 225 GLY 225 216 216 GLY GLY A . n 
B 2 226 ARG 226 217 217 ARG ARG A . n 
B 2 227 ASP 227 218 218 ASP ASP A . n 
B 2 228 ASN 228 219 219 ASN ASN A . n 
B 2 229 GLY 229 220 220 GLY GLY A . n 
B 2 230 GLN 230 221 221 GLN GLN A . n 
B 2 231 LEU 231 222 222 LEU LEU A . n 
B 2 232 LEU 232 223 223 LEU LEU A . n 
B 2 233 GLY 233 224 224 GLY GLY A . n 
B 2 234 GLU 234 225 225 GLU GLU A . n 
B 2 235 ARG 235 226 226 ARG ARG A . n 
B 2 236 VAL 236 227 227 VAL VAL A . n 
B 2 237 ALA 237 228 228 ALA ALA A . n 
B 2 238 ARG 238 229 229 ARG ARG A . n 
B 2 239 ARG 239 230 230 ARG ARG A . n 
B 2 240 ASP 240 231 231 ASP ASP A . n 
B 2 241 ILE 241 232 232 ILE ILE A . n 
B 2 242 CYS 242 233 233 CYS CYS A . n 
B 2 243 ILE 243 234 234 ILE ILE A . n 
B 2 244 ALA 244 235 235 ALA ALA A . n 
B 2 245 PHE 245 236 236 PHE PHE A . n 
B 2 246 GLN 246 237 237 GLN GLN A . n 
B 2 247 GLU 247 238 238 GLU GLU A . n 
B 2 248 THR 248 239 239 THR THR A . n 
B 2 249 LEU 249 240 240 LEU LEU A . n 
B 2 250 PRO 250 241 241 PRO PRO A . n 
B 2 251 THR 251 242 242 THR THR A . n 
B 2 252 LEU 252 243 243 LEU LEU A . n 
B 2 253 GLN 253 244 244 GLN GLN A . n 
B 2 254 PRO 254 245 245 PRO PRO A . n 
B 2 255 ASN 255 246 246 ASN ASN A . n 
B 2 256 GLN 256 247 247 GLN GLN A . n 
B 2 257 ASN 257 248 248 ASN ASN A . n 
B 2 258 MET 258 249 249 MET MET A . n 
B 2 259 THR 259 250 250 THR THR A . n 
B 2 260 SER 260 251 251 SER SER A . n 
B 2 261 GLU 261 252 252 GLU GLU A . n 
B 2 262 GLU 262 253 253 GLU GLU A . n 
B 2 263 ARG 263 254 254 ARG ARG A . n 
B 2 264 GLN 264 255 255 GLN GLN A . n 
B 2 265 ARG 265 256 256 ARG ARG A . n 
B 2 266 LEU 266 257 257 LEU LEU A . n 
B 2 267 VAL 267 258 258 VAL VAL A . n 
B 2 268 THR 268 259 259 THR THR A . n 
B 2 269 ILE 269 260 260 ILE ILE A . n 
B 2 270 VAL 270 261 261 VAL VAL A . n 
B 2 271 ASP 271 262 262 ASP ASP A . n 
B 2 272 LYS 272 263 263 LYS LYS A . n 
B 2 273 LEU 273 264 264 LEU LEU A . n 
B 2 274 GLN 274 265 265 GLN GLN A . n 
B 2 275 GLN 275 266 266 GLN GLN A . n 
B 2 276 SER 276 267 267 SER SER A . n 
B 2 277 THR 277 268 268 THR THR A . n 
B 2 278 ALA 278 269 269 ALA ALA A . n 
B 2 279 ARG 279 270 270 ARG ARG A . n 
B 2 280 VAL 280 271 271 VAL VAL A . n 
B 2 281 VAL 281 272 272 VAL VAL A . n 
B 2 282 VAL 282 273 273 VAL VAL A . n 
B 2 283 VAL 283 274 274 VAL VAL A . n 
B 2 284 PHE 284 275 275 PHE PHE A . n 
B 2 285 SER 285 276 276 SER SER A . n 
B 2 286 PRO 286 277 277 PRO PRO A . n 
B 2 287 ASP 287 278 278 ASP ASP A . n 
B 2 288 LEU 288 279 279 LEU LEU A . n 
B 2 289 THR 289 280 280 THR THR A . n 
B 2 290 LEU 290 281 281 LEU LEU A . n 
B 2 291 TYR 291 282 282 TYR TYR A . n 
B 2 292 HIS 292 283 283 HIS HIS A . n 
B 2 293 PHE 293 284 284 PHE PHE A . n 
B 2 294 PHE 294 285 285 PHE PHE A . n 
B 2 295 ASN 295 286 286 ASN ASN A . n 
B 2 296 GLU 296 287 287 GLU GLU A . n 
B 2 297 VAL 297 288 288 VAL VAL A . n 
B 2 298 LEU 298 289 289 LEU LEU A . n 
B 2 299 ARG 299 290 290 ARG ARG A . n 
B 2 300 GLN 300 291 291 GLN GLN A . n 
B 2 301 ASN 301 292 292 ASN ASN A . n 
B 2 302 PHE 302 293 293 PHE PHE A . n 
B 2 303 THR 303 294 294 THR THR A . n 
B 2 304 GLY 304 295 295 GLY GLY A . n 
B 2 305 ALA 305 296 296 ALA ALA A . n 
B 2 306 VAL 306 297 297 VAL VAL A . n 
B 2 307 TRP 307 298 298 TRP TRP A . n 
B 2 308 ILE 308 299 299 ILE ILE A . n 
B 2 309 ALA 309 300 300 ALA ALA A . n 
B 2 310 SER 310 301 301 SER SER A . n 
B 2 311 GLU 311 302 302 GLU GLU A . n 
B 2 312 SER 312 303 303 SER SER A . n 
B 2 313 TRP 313 304 304 TRP TRP A . n 
B 2 314 ALA 314 305 305 ALA ALA A . n 
B 2 315 ILE 315 306 306 ILE ILE A . n 
B 2 316 ASP 316 307 307 ASP ASP A . n 
B 2 317 PRO 317 308 308 PRO PRO A . n 
B 2 318 VAL 318 309 309 VAL VAL A . n 
B 2 319 LEU 319 310 310 LEU LEU A . n 
B 2 320 HIS 320 311 311 HIS HIS A . n 
B 2 321 ASN 321 312 312 ASN ASN A . n 
B 2 322 LEU 322 313 313 LEU LEU A . n 
B 2 323 THR 323 314 314 THR THR A . n 
B 2 324 GLU 324 315 315 GLU GLU A . n 
B 2 325 LEU 325 316 316 LEU LEU A . n 
B 2 326 ARG 326 317 317 ARG ARG A . n 
B 2 327 HIS 327 318 318 HIS HIS A . n 
B 2 328 LEU 328 319 319 LEU LEU A . n 
B 2 329 GLY 329 320 320 GLY GLY A . n 
B 2 330 THR 330 321 321 THR THR A . n 
B 2 331 PHE 331 322 322 PHE PHE A . n 
B 2 332 LEU 332 323 323 LEU LEU A . n 
B 2 333 GLY 333 324 324 GLY GLY A . n 
B 2 334 ILE 334 325 325 ILE ILE A . n 
B 2 335 THR 335 326 326 THR THR A . n 
B 2 336 ILE 336 327 327 ILE ILE A . n 
B 2 337 GLN 337 328 328 GLN GLN A . n 
B 2 338 SER 338 329 329 SER SER A . n 
B 2 339 VAL 339 330 330 VAL VAL A . n 
B 2 340 PRO 340 331 331 PRO PRO A . n 
B 2 341 ILE 341 332 332 ILE ILE A . n 
B 2 342 PRO 342 333 333 PRO PRO A . n 
B 2 343 GLY 343 334 334 GLY GLY A . n 
B 2 344 PHE 344 335 335 PHE PHE A . n 
B 2 345 SER 345 336 336 SER SER A . n 
B 2 346 GLU 346 337 337 GLU GLU A . n 
B 2 347 PHE 347 338 338 PHE PHE A . n 
B 2 348 ARG 348 339 339 ARG ARG A . n 
B 2 349 GLU 349 340 340 GLU GLU A . n 
B 2 350 TRP 350 341 341 TRP TRP A . n 
B 2 351 GLY 351 342 342 GLY GLY A . n 
B 2 352 PRO 352 343 ?   ?   ?   A . n 
B 2 353 GLN 353 344 ?   ?   ?   A . n 
B 2 354 ALA 354 345 ?   ?   ?   A . n 
B 2 355 GLY 355 346 ?   ?   ?   A . n 
B 2 356 PRO 356 347 ?   ?   ?   A . n 
B 2 357 PRO 357 348 ?   ?   ?   A . n 
B 2 358 PRO 358 349 ?   ?   ?   A . n 
B 2 359 LEU 359 350 ?   ?   ?   A . n 
B 2 360 SER 360 351 ?   ?   ?   A . n 
B 2 361 ARG 361 352 ?   ?   ?   A . n 
B 2 362 THR 362 353 ?   ?   ?   A . n 
B 2 363 SER 363 354 ?   ?   ?   A . n 
B 2 364 GLN 364 355 ?   ?   ?   A . n 
B 2 365 SER 365 356 ?   ?   ?   A . n 
B 2 366 TYR 366 357 ?   ?   ?   A . n 
B 2 367 THR 367 358 358 THR THR A . n 
B 2 368 CYS 368 359 359 CYS CYS A . n 
B 2 369 ASN 369 360 360 ASN ASN A . n 
B 2 370 GLN 370 361 361 GLN GLN A . n 
B 2 371 GLU 371 362 362 GLU GLU A . n 
B 2 372 CYS 372 363 363 CYS CYS A . n 
B 2 373 ASP 373 364 364 ASP ASP A . n 
B 2 374 ASN 374 365 365 ASN ASN A . n 
B 2 375 CYS 375 366 366 CYS CYS A . n 
B 2 376 LEU 376 367 367 LEU LEU A . n 
B 2 377 ASN 377 368 368 ASN ASN A . n 
B 2 378 ALA 378 369 369 ALA ALA A . n 
B 2 379 THR 379 370 370 THR THR A . n 
B 2 380 LEU 380 371 371 LEU LEU A . n 
B 2 381 SER 381 372 372 SER SER A . n 
B 2 382 PHE 382 373 373 PHE PHE A . n 
B 2 383 ASN 383 374 374 ASN ASN A . n 
B 2 384 THR 384 375 375 THR THR A . n 
B 2 385 ILE 385 376 376 ILE ILE A . n 
B 2 386 LEU 386 377 377 LEU LEU A . n 
B 2 387 ARG 387 378 378 ARG ARG A . n 
B 2 388 LEU 388 379 379 LEU LEU A . n 
B 2 389 SER 389 380 380 SER SER A . n 
B 2 390 GLY 390 381 381 GLY GLY A . n 
B 2 391 GLU 391 382 382 GLU GLU A . n 
B 2 392 ARG 392 383 383 ARG ARG A . n 
B 2 393 VAL 393 384 384 VAL VAL A . n 
B 2 394 VAL 394 385 385 VAL VAL A . n 
B 2 395 TYR 395 386 386 TYR TYR A . n 
B 2 396 SER 396 387 387 SER SER A . n 
B 2 397 VAL 397 388 388 VAL VAL A . n 
B 2 398 TYR 398 389 389 TYR TYR A . n 
B 2 399 SER 399 390 390 SER SER A . n 
B 2 400 ALA 400 391 391 ALA ALA A . n 
B 2 401 VAL 401 392 392 VAL VAL A . n 
B 2 402 TYR 402 393 393 TYR TYR A . n 
B 2 403 ALA 403 394 394 ALA ALA A . n 
B 2 404 VAL 404 395 395 VAL VAL A . n 
B 2 405 ALA 405 396 396 ALA ALA A . n 
B 2 406 HIS 406 397 397 HIS HIS A . n 
B 2 407 ALA 407 398 398 ALA ALA A . n 
B 2 408 LEU 408 399 399 LEU LEU A . n 
B 2 409 HIS 409 400 400 HIS HIS A . n 
B 2 410 SER 410 401 401 SER SER A . n 
B 2 411 LEU 411 402 402 LEU LEU A . n 
B 2 412 LEU 412 403 403 LEU LEU A . n 
B 2 413 GLY 413 404 404 GLY GLY A . n 
B 2 414 CYS 414 405 405 CYS CYS A . n 
B 2 415 ASP 415 406 406 ASP ASP A . n 
B 2 416 LYS 416 407 407 LYS LYS A . n 
B 2 417 SER 417 408 408 SER SER A . n 
B 2 418 THR 418 409 409 THR THR A . n 
B 2 419 CYS 419 410 410 CYS CYS A . n 
B 2 420 THR 420 411 411 THR THR A . n 
B 2 421 LYS 421 412 412 LYS LYS A . n 
B 2 422 ARG 422 413 413 ARG ARG A . n 
B 2 423 VAL 423 414 414 VAL VAL A . n 
B 2 424 VAL 424 415 415 VAL VAL A . n 
B 2 425 TYR 425 416 416 TYR TYR A . n 
B 2 426 PRO 426 417 417 PRO PRO A . n 
B 2 427 TRP 427 418 418 TRP TRP A . n 
B 2 428 GLN 428 419 419 GLN GLN A . n 
B 2 429 LEU 429 420 420 LEU LEU A . n 
B 2 430 LEU 430 421 421 LEU LEU A . n 
B 2 431 GLU 431 422 422 GLU GLU A . n 
B 2 432 GLU 432 423 423 GLU GLU A . n 
B 2 433 ILE 433 424 424 ILE ILE A . n 
B 2 434 TRP 434 425 425 TRP TRP A . n 
B 2 435 LYS 435 426 426 LYS LYS A . n 
B 2 436 VAL 436 427 427 VAL VAL A . n 
B 2 437 ASN 437 428 428 ASN ASN A . n 
B 2 438 PHE 438 429 429 PHE PHE A . n 
B 2 439 THR 439 430 430 THR THR A . n 
B 2 440 LEU 440 431 431 LEU LEU A . n 
B 2 441 LEU 441 432 432 LEU LEU A . n 
B 2 442 ASP 442 433 433 ASP ASP A . n 
B 2 443 HIS 443 434 434 HIS HIS A . n 
B 2 444 GLN 444 435 435 GLN GLN A . n 
B 2 445 ILE 445 436 436 ILE ILE A . n 
B 2 446 PHE 446 437 437 PHE PHE A . n 
B 2 447 PHE 447 438 438 PHE PHE A . n 
B 2 448 ASP 448 439 439 ASP ASP A . n 
B 2 449 PRO 449 440 440 PRO PRO A . n 
B 2 450 GLN 450 441 441 GLN GLN A . n 
B 2 451 GLY 451 442 442 GLY GLY A . n 
B 2 452 ASP 452 443 443 ASP ASP A . n 
B 2 453 VAL 453 444 444 VAL VAL A . n 
B 2 454 ALA 454 445 445 ALA ALA A . n 
B 2 455 LEU 455 446 446 LEU LEU A . n 
B 2 456 HIS 456 447 447 HIS HIS A . n 
B 2 457 LEU 457 448 448 LEU LEU A . n 
B 2 458 GLU 458 449 449 GLU GLU A . n 
B 2 459 ILE 459 450 450 ILE ILE A . n 
B 2 460 VAL 460 451 451 VAL VAL A . n 
B 2 461 GLN 461 452 452 GLN GLN A . n 
B 2 462 TRP 462 453 453 TRP TRP A . n 
B 2 463 GLN 463 454 454 GLN GLN A . n 
B 2 464 TRP 464 455 455 TRP TRP A . n 
B 2 465 ASP 465 456 456 ASP ASP A . n 
B 2 466 ARG 466 457 457 ARG ARG A . n 
B 2 467 SER 467 458 458 SER SER A . n 
B 2 468 GLN 468 459 459 GLN GLN A . n 
B 2 469 ASN 469 460 460 ASN ASN A . n 
B 2 470 PRO 470 461 461 PRO PRO A . n 
B 2 471 PHE 471 462 462 PHE PHE A . n 
B 2 472 GLN 472 463 463 GLN GLN A . n 
B 2 473 SER 473 464 464 SER SER A . n 
B 2 474 VAL 474 465 465 VAL VAL A . n 
B 2 475 ALA 475 466 466 ALA ALA A . n 
B 2 476 SER 476 467 467 SER SER A . n 
B 2 477 TYR 477 468 468 TYR TYR A . n 
B 2 478 TYR 478 469 469 TYR TYR A . n 
B 2 479 PRO 479 470 470 PRO PRO A . n 
B 2 480 LEU 480 471 471 LEU LEU A . n 
B 2 481 GLN 481 472 472 GLN GLN A . n 
B 2 482 ARG 482 473 473 ARG ARG A . n 
B 2 483 GLN 483 474 474 GLN GLN A . n 
B 2 484 LEU 484 475 475 LEU LEU A . n 
B 2 485 LYS 485 476 476 LYS LYS A . n 
B 2 486 ASN 486 477 477 ASN ASN A . n 
B 2 487 ILE 487 478 478 ILE ILE A . n 
B 2 488 GLN 488 479 479 GLN GLN A . n 
B 2 489 ASP 489 480 480 ASP ASP A . n 
B 2 490 ILE 490 481 481 ILE ILE A . n 
B 2 491 SER 491 482 482 SER SER A . n 
B 2 492 TRP 492 483 483 TRP TRP A . n 
B 2 493 HIS 493 484 484 HIS HIS A . n 
B 2 494 THR 494 485 485 THR THR A . n 
B 2 495 ILE 495 486 486 ILE ILE A . n 
B 2 496 ASN 496 487 487 ASN ASN A . n 
B 2 497 ASN 497 488 488 ASN ASN A . n 
B 2 498 THR 498 489 489 THR THR A . n 
B 2 499 ILE 499 490 490 ILE ILE A . n 
B 2 500 PRO 500 491 491 PRO PRO A . n 
B 2 501 MET 501 492 492 MET MET A . n 
B 2 502 SER 502 493 493 SER SER A . n 
B 2 503 MET 503 494 494 MET MET A . n 
B 2 504 CYS 504 495 495 CYS CYS A . n 
B 2 505 SER 505 496 496 SER SER A . n 
B 2 506 LYS 506 497 497 LYS LYS A . n 
B 2 507 ARG 507 498 498 ARG ARG A . n 
B 2 508 CYS 508 499 499 CYS CYS A . n 
B 2 509 GLN 509 500 ?   ?   ?   A . n 
B 2 510 SER 510 501 ?   ?   ?   A . n 
B 2 511 GLY 511 502 ?   ?   ?   A . n 
B 2 512 GLN 512 503 ?   ?   ?   A . n 
B 2 513 LYS 513 504 ?   ?   ?   A . n 
B 2 514 LYS 514 505 505 LYS LYS A . n 
B 2 515 LYS 515 506 506 LYS LYS A . n 
B 2 516 PRO 516 507 507 PRO PRO A . n 
B 2 517 VAL 517 508 508 VAL VAL A . n 
B 2 518 GLY 518 509 509 GLY GLY A . n 
B 2 519 ILE 519 510 510 ILE ILE A . n 
B 2 520 HIS 520 511 511 HIS HIS A . n 
B 2 521 VAL 521 512 512 VAL VAL A . n 
B 2 522 CYS 522 513 513 CYS CYS A . n 
B 2 523 CYS 523 514 514 CYS CYS A . n 
B 2 524 PHE 524 515 515 PHE PHE A . n 
B 2 525 GLU 525 516 516 GLU GLU A . n 
B 2 526 CYS 526 517 517 CYS CYS A . n 
B 2 527 ILE 527 518 518 ILE ILE A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 3 RRY 1 C RRY 1 C 40J 1 n 
C 3 RRJ 2 C RRJ 2 C 40J 1 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 RRJ ? ? RRJ ? ? 'SUBJECT OF INVESTIGATION' ? 
2 RRY ? ? RRY ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 NAG 1 601 2000 NAG NAG B . 
E 4 NAG 1 602 2001 NAG NAG B . 
F 4 NAG 1 603 2002 NAG NAG B . 
G 4 NAG 1 604 2003 NAG NAG B . 
H 4 NAG 1 605 2004 NAG NAG B . 
I 4 NAG 1 606 2005 NAG NAG B . 
J 4 NAG 1 607 2006 NAG NAG B . 
K 4 NAG 1 608 2007 NAG NAG B . 
L 4 NAG 1 601 2001 NAG NAG A . 
M 4 NAG 1 602 2002 NAG NAG A . 
N 4 NAG 1 603 2003 NAG NAG A . 
O 4 NAG 1 604 2004 NAG NAG A . 
P 4 NAG 1 605 2005 NAG NAG A . 
Q 4 NAG 1 606 2006 NAG NAG A . 
R 4 NAG 1 607 2007 NAG NAG A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9NOV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9NOV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9NOV 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9NOV 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.30 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004 ? 7828  ? f_bond_d           ? ? ? 
'ELECTRON MICROSCOPY' ? 0.520 ? 10645 ? f_angle_d          ? ? ? 
'ELECTRON MICROSCOPY' ? 8.483 ? 1335  ? f_dihedral_angle_d ? ? ? 
'ELECTRON MICROSCOPY' ? 0.044 ? 1241  ? f_chiral_restr     ? ? ? 
'ELECTRON MICROSCOPY' ? 0.003 ? 1338  ? f_plane_restr      ? ? ? 
# 
_struct.entry_id                     9NOV 
_struct.title                        'Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to sucralose' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9NOV 
_struct_keywords.text            'Sweet, taste, receptor, GPCR, TAS1R2, TAS1R3, T1R2, T1R3, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 4 ? 
R N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP TS1R3_HUMAN Q7RTX0 ? 1 
;APLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLF
DTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETF
PSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVL
HQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKT
HLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDP
VKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCS
RQCQEGQVRRVKGFHSCCYDC
;
21 
2 UNP TS1R2_HUMAN Q8TE23 ? 2 
;AEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEI
VDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFP
ALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLV
TIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEF
REWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPW
QLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKR
CQSGQKKKPVGIHVCCFECI
;
19 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9NOV B 28 ? 528 ? Q7RTX0 21 ? 521 ? 21 521 
2 2 9NOV A 28 ? 527 ? Q8TE23 19 ? 518 ? 19 518 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9NOV MET B 1  ? UNP Q7RTX0 ? ? 'expression tag'        -6 1  
1 9NOV LYS B 2  ? UNP Q7RTX0 ? ? 'expression tag'        -5 2  
1 9NOV THR B 3  ? UNP Q7RTX0 ? ? 'expression tag'        -4 3  
1 9NOV ILE B 4  ? UNP Q7RTX0 ? ? 'expression tag'        -3 4  
1 9NOV ILE B 5  ? UNP Q7RTX0 ? ? 'expression tag'        -2 5  
1 9NOV ALA B 6  ? UNP Q7RTX0 ? ? 'expression tag'        -1 6  
1 9NOV LEU B 7  ? UNP Q7RTX0 ? ? 'expression tag'        0  7  
1 9NOV SER B 8  ? UNP Q7RTX0 ? ? 'expression tag'        1  8  
1 9NOV TYR B 9  ? UNP Q7RTX0 ? ? 'expression tag'        2  9  
1 9NOV ILE B 10 ? UNP Q7RTX0 ? ? 'expression tag'        3  10 
1 9NOV PHE B 11 ? UNP Q7RTX0 ? ? 'expression tag'        4  11 
1 9NOV CYS B 12 ? UNP Q7RTX0 ? ? 'expression tag'        5  12 
1 9NOV LEU B 13 ? UNP Q7RTX0 ? ? 'expression tag'        6  13 
1 9NOV VAL B 14 ? UNP Q7RTX0 ? ? 'expression tag'        7  14 
1 9NOV PHE B 15 ? UNP Q7RTX0 ? ? 'expression tag'        8  15 
1 9NOV ALA B 16 ? UNP Q7RTX0 ? ? 'expression tag'        9  16 
1 9NOV ASP B 17 ? UNP Q7RTX0 ? ? 'expression tag'        10 17 
1 9NOV TYR B 18 ? UNP Q7RTX0 ? ? 'expression tag'        11 18 
1 9NOV LYS B 19 ? UNP Q7RTX0 ? ? 'expression tag'        12 19 
1 9NOV ASP B 20 ? UNP Q7RTX0 ? ? 'expression tag'        13 20 
1 9NOV ASP B 21 ? UNP Q7RTX0 ? ? 'expression tag'        14 21 
1 9NOV ASP B 22 ? UNP Q7RTX0 ? ? 'expression tag'        15 22 
1 9NOV ASP B 23 ? UNP Q7RTX0 ? ? 'expression tag'        16 23 
1 9NOV LYS B 24 ? UNP Q7RTX0 ? ? 'expression tag'        17 24 
1 9NOV ALA B 25 ? UNP Q7RTX0 ? ? 'expression tag'        18 25 
1 9NOV ALA B 26 ? UNP Q7RTX0 ? ? 'expression tag'        19 26 
1 9NOV ALA B 27 ? UNP Q7RTX0 ? ? 'expression tag'        20 27 
2 9NOV MET A 1  ? UNP Q8TE23 ? ? 'initiating methionine' -8 28 
2 9NOV LYS A 2  ? UNP Q8TE23 ? ? 'expression tag'        -7 29 
2 9NOV THR A 3  ? UNP Q8TE23 ? ? 'expression tag'        -6 30 
2 9NOV ILE A 4  ? UNP Q8TE23 ? ? 'expression tag'        -5 31 
2 9NOV ILE A 5  ? UNP Q8TE23 ? ? 'expression tag'        -4 32 
2 9NOV ALA A 6  ? UNP Q8TE23 ? ? 'expression tag'        -3 33 
2 9NOV LEU A 7  ? UNP Q8TE23 ? ? 'expression tag'        -2 34 
2 9NOV SER A 8  ? UNP Q8TE23 ? ? 'expression tag'        -1 35 
2 9NOV TYR A 9  ? UNP Q8TE23 ? ? 'expression tag'        0  36 
2 9NOV ILE A 10 ? UNP Q8TE23 ? ? 'expression tag'        1  37 
2 9NOV PHE A 11 ? UNP Q8TE23 ? ? 'expression tag'        2  38 
2 9NOV CYS A 12 ? UNP Q8TE23 ? ? 'expression tag'        3  39 
2 9NOV LEU A 13 ? UNP Q8TE23 ? ? 'expression tag'        4  40 
2 9NOV VAL A 14 ? UNP Q8TE23 ? ? 'expression tag'        5  41 
2 9NOV PHE A 15 ? UNP Q8TE23 ? ? 'expression tag'        6  42 
2 9NOV ALA A 16 ? UNP Q8TE23 ? ? 'expression tag'        7  43 
2 9NOV TYR A 17 ? UNP Q8TE23 ? ? 'expression tag'        8  44 
2 9NOV PRO A 18 ? UNP Q8TE23 ? ? 'expression tag'        9  45 
2 9NOV TYR A 19 ? UNP Q8TE23 ? ? 'expression tag'        10 46 
2 9NOV ASP A 20 ? UNP Q8TE23 ? ? 'expression tag'        11 47 
2 9NOV VAL A 21 ? UNP Q8TE23 ? ? 'expression tag'        12 48 
2 9NOV PRO A 22 ? UNP Q8TE23 ? ? 'expression tag'        13 49 
2 9NOV ASP A 23 ? UNP Q8TE23 ? ? 'expression tag'        14 50 
2 9NOV TYR A 24 ? UNP Q8TE23 ? ? 'expression tag'        15 51 
2 9NOV ALA A 25 ? UNP Q8TE23 ? ? 'expression tag'        16 52 
2 9NOV ALA A 26 ? UNP Q8TE23 ? ? 'expression tag'        17 53 
2 9NOV ALA A 27 ? UNP Q8TE23 ? ? 'expression tag'        18 54 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 32  ? GLN A 35  ? LEU B 25  GLN B 28  5 ? 4  
HELX_P HELX_P2  AA2 SER A 73  ? LYS A 93  ? SER B 66  LYS B 86  1 ? 21 
HELX_P HELX_P3  AA3 GLU A 112 ? ALA A 125 ? GLU B 105 ALA B 118 1 ? 14 
HELX_P HELX_P4  AA4 ASN A 137 ? TYR A 141 ? ASN B 130 TYR B 134 5 ? 5  
HELX_P HELX_P5  AA5 SER A 153 ? SER A 165 ? SER B 146 SER B 158 1 ? 13 
HELX_P HELX_P6  AA6 MET A 178 ? ALA A 183 ? MET B 171 ALA B 176 5 ? 6  
HELX_P HELX_P7  AA7 SER A 196 ? GLY A 212 ? SER B 189 GLY B 205 1 ? 17 
HELX_P HELX_P8  AA8 ASP A 223 ? GLY A 241 ? ASP B 216 GLY B 234 1 ? 19 
HELX_P HELX_P9  AA9 VAL A 263 ? SER A 273 ? VAL B 256 SER B 266 1 ? 11 
HELX_P HELX_P10 AB1 SER A 283 ? SER A 297 ? SER B 276 SER B 290 1 ? 15 
HELX_P HELX_P11 AB2 SER A 313 ? GLY A 318 ? SER B 306 GLY B 311 1 ? 6  
HELX_P HELX_P12 AB3 GLY A 321 ? MET A 325 ? GLY B 314 MET B 318 5 ? 5  
HELX_P HELX_P13 AB4 GLU A 340 ? THR A 353 ? GLU B 333 THR B 346 1 ? 14 
HELX_P HELX_P14 AB5 ASP A 354 ? LEU A 361 ? ASP B 347 LEU B 354 1 ? 8  
HELX_P HELX_P15 AB6 CYS A 377 ? ASP A 381 ? CYS B 370 ASP B 374 5 ? 5  
HELX_P HELX_P16 AB7 THR A 384 ? VAL A 388 ? THR B 377 VAL B 381 5 ? 5  
HELX_P HELX_P17 AB8 SER A 389 ? HIS A 394 ? SER B 382 HIS B 387 5 ? 6  
HELX_P HELX_P18 AB9 HIS A 395 ? LEU A 415 ? HIS B 388 LEU B 408 1 ? 21 
HELX_P HELX_P19 AC1 LYS A 429 ? TRP A 431 ? LYS B 422 TRP B 424 5 ? 3  
HELX_P HELX_P20 AC2 GLN A 432 ? TYR A 438 ? GLN B 425 TYR B 431 1 ? 7  
HELX_P HELX_P21 AC3 ARG A 489 ? ILE A 492 ? ARG B 482 ILE B 485 5 ? 4  
HELX_P HELX_P22 AC4 MET B 67  ? TYR B 71  ? MET A 58  TYR A 62  5 ? 5  
HELX_P HELX_P23 AC5 LYS B 74  ? ASP B 94  ? LYS A 65  ASP A 85  1 ? 21 
HELX_P HELX_P24 AC6 VAL B 117 ? ALA B 125 ? VAL A 108 ALA A 116 1 ? 9  
HELX_P HELX_P25 AC7 ASN B 152 ? SER B 164 ? ASN A 143 SER A 155 1 ? 13 
HELX_P HELX_P26 AC8 SER B 177 ? ARG B 181 ? SER A 168 ARG A 172 5 ? 5  
HELX_P HELX_P27 AC9 SER B 195 ? PHE B 210 ? SER A 186 PHE A 201 1 ? 16 
HELX_P HELX_P28 AD1 ASP B 222 ? ALA B 237 ? ASP A 213 ALA A 228 1 ? 16 
HELX_P HELX_P29 AD2 THR B 259 ? SER B 276 ? THR A 250 SER A 267 1 ? 18 
HELX_P HELX_P30 AD3 THR B 289 ? ASN B 301 ? THR A 280 ASN A 292 1 ? 13 
HELX_P HELX_P31 AD4 ASP B 316 ? ASN B 321 ? ASP A 307 ASN A 312 1 ? 6  
HELX_P HELX_P32 AD5 LEU B 325 ? HIS B 327 ? LEU A 316 HIS A 318 5 ? 3  
HELX_P HELX_P33 AD6 GLY B 343 ? GLY B 351 ? GLY A 334 GLY A 342 1 ? 9  
HELX_P HELX_P34 AD7 ASP B 373 ? SER B 381 ? ASP A 364 SER A 372 1 ? 9  
HELX_P HELX_P35 AD8 PHE B 382 ? GLY B 390 ? PHE A 373 GLY A 381 1 ? 9  
HELX_P HELX_P36 AD9 ARG B 392 ? GLY B 413 ? ARG A 383 GLY A 404 1 ? 22 
HELX_P HELX_P37 AE1 TYR B 425 ? TRP B 434 ? TYR A 416 TRP A 425 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?   ? A CYS 31  SG  ? ? ? 1_555 A CYS 358 SG ? ? B CYS 24  B CYS 351 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf2  disulf ?   ? A CYS 69  SG  ? ? ? 1_555 A CYS 110 SG ? ? B CYS 62  B CYS 103 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf3  disulf ?   ? A CYS 136 SG  ? ? ? 1_555 B CYS 368 SG ? ? B CYS 129 A CYS 359 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf4  disulf ?   ? A CYS 243 SG  ? ? ? 1_555 A CYS 524 SG ? ? B CYS 236 B CYS 517 1_555 ? ? ? ? ? ? ? 2.027 ? ?               
disulf5  disulf ?   ? A CYS 377 SG  ? ? ? 1_555 A CYS 380 SG ? ? B CYS 370 B CYS 373 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf6  disulf ?   ? A CYS 417 SG  ? ? ? 1_555 A CYS 422 SG ? ? B CYS 410 B CYS 415 1_555 ? ? ? ? ? ? ? 2.027 ? ?               
disulf7  disulf ?   ? A CYS 506 SG  ? ? ? 1_555 A CYS 525 SG ? ? B CYS 499 B CYS 518 1_555 ? ? ? ? ? ? ? 2.027 ? ?               
disulf8  disulf ?   ? A CYS 510 SG  ? ? ? 1_555 A CYS 528 SG ? ? B CYS 503 B CYS 521 1_555 ? ? ? ? ? ? ? 2.028 ? ?               
disulf9  disulf ?   ? B CYS 68  SG  ? ? ? 1_555 B CYS 111 SG ? ? A CYS 59  A CYS 102 1_555 ? ? ? ? ? ? ? 2.032 ? ?               
disulf10 disulf ?   ? B CYS 242 SG  ? ? ? 1_555 B CYS 522 SG ? ? A CYS 233 A CYS 513 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf11 disulf ?   ? B CYS 372 SG  ? ? ? 1_555 B CYS 375 SG ? ? A CYS 363 A CYS 366 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf12 disulf ?   ? B CYS 414 SG  ? ? ? 1_555 B CYS 419 SG ? ? A CYS 405 A CYS 410 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf13 disulf ?   ? B CYS 504 SG  ? ? ? 1_555 B CYS 523 SG ? ? A CYS 495 A CYS 514 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf14 disulf ?   ? B CYS 508 SG  ? ? ? 1_555 B CYS 526 SG ? ? A CYS 499 A CYS 517 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
covale1  covale one ? A ASN 92  ND2 ? ? ? 1_555 H NAG .   C1 ? ? B ASN 85  B NAG 605 1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale2  covale one ? A ASN 137 ND2 ? ? ? 1_555 I NAG .   C1 ? ? B ASN 130 B NAG 606 1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale3  covale one ? A ASN 271 ND2 ? ? ? 1_555 F NAG .   C1 ? ? B ASN 264 B NAG 603 1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale4  covale one ? A ASN 292 ND2 ? ? ? 1_555 E NAG .   C1 ? ? B ASN 285 B NAG 602 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale5  covale one ? A ASN 387 ND2 ? ? ? 1_555 J NAG .   C1 ? ? B ASN 380 B NAG 607 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale6  covale one ? A ASN 418 ND2 ? ? ? 1_555 G NAG .   C1 ? ? B ASN 411 B NAG 604 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale7  covale one ? A ASN 439 ND2 ? ? ? 1_555 K NAG .   C1 ? ? B ASN 432 B NAG 608 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale8  covale one ? A ASN 482 ND2 ? ? ? 1_555 D NAG .   C1 ? ? B ASN 475 B NAG 601 1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale9  covale one ? B ASN 93  ND2 ? ? ? 1_555 M NAG .   C1 ? ? A ASN 84  A NAG 602 1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
covale10 covale one ? B ASN 257 ND2 ? ? ? 1_555 P NAG .   C1 ? ? A ASN 248 A NAG 605 1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation 
covale11 covale one ? B ASN 301 ND2 ? ? ? 1_555 Q NAG .   C1 ? ? A ASN 292 A NAG 606 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale12 covale one ? B ASN 321 ND2 ? ? ? 1_555 O NAG .   C1 ? ? A ASN 312 A NAG 604 1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale13 covale one ? B ASN 377 ND2 ? ? ? 1_555 R NAG .   C1 ? ? A ASN 368 A NAG 607 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale14 covale one ? B ASN 437 ND2 ? ? ? 1_555 N NAG .   C1 ? ? A ASN 428 A NAG 603 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale15 covale one ? B ASN 496 ND2 ? ? ? 1_555 L NAG .   C1 ? ? A ASN 487 A NAG 601 1_555 ? ? ? ? ? ? ? 1.438 ? N-Glycosylation 
covale16 covale one ? C RRY .   O2  ? ? ? 1_555 C RRJ .   C1 ? ? C RRY 1   C RRJ 2   1_555 ? ? ? ? ? ? ? 1.388 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG D .   ? ASN A 482 ? NAG B 601 ? 1_555 ASN B 475 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG E .   ? ASN A 292 ? NAG B 602 ? 1_555 ASN B 285 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG F .   ? ASN A 271 ? NAG B 603 ? 1_555 ASN B 264 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG G .   ? ASN A 418 ? NAG B 604 ? 1_555 ASN B 411 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG H .   ? ASN A 92  ? NAG B 605 ? 1_555 ASN B 85  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG I .   ? ASN A 137 ? NAG B 606 ? 1_555 ASN B 130 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  NAG J .   ? ASN A 387 ? NAG B 607 ? 1_555 ASN B 380 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
8  NAG K .   ? ASN A 439 ? NAG B 608 ? 1_555 ASN B 432 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
9  NAG L .   ? ASN B 496 ? NAG A 601 ? 1_555 ASN A 487 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
10 NAG M .   ? ASN B 93  ? NAG A 602 ? 1_555 ASN A 84  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
11 NAG N .   ? ASN B 437 ? NAG A 603 ? 1_555 ASN A 428 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
12 NAG O .   ? ASN B 321 ? NAG A 604 ? 1_555 ASN A 312 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
13 NAG P .   ? ASN B 257 ? NAG A 605 ? 1_555 ASN A 248 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
14 NAG Q .   ? ASN B 301 ? NAG A 606 ? 1_555 ASN A 292 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
15 NAG R .   ? ASN B 377 ? NAG A 607 ? 1_555 ASN A 368 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
16 CYS A 31  ? CYS A 358 ? CYS B 24  ? 1_555 CYS B 351 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
17 CYS A 69  ? CYS A 110 ? CYS B 62  ? 1_555 CYS B 103 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
18 CYS A 136 ? CYS B 368 ? CYS B 129 ? 1_555 CYS A 359 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
19 CYS A 243 ? CYS A 524 ? CYS B 236 ? 1_555 CYS B 517 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
20 CYS A 377 ? CYS A 380 ? CYS B 370 ? 1_555 CYS B 373 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
21 CYS A 417 ? CYS A 422 ? CYS B 410 ? 1_555 CYS B 415 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
22 CYS A 506 ? CYS A 525 ? CYS B 499 ? 1_555 CYS B 518 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
23 CYS A 510 ? CYS A 528 ? CYS B 503 ? 1_555 CYS B 521 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
24 CYS B 68  ? CYS B 111 ? CYS A 59  ? 1_555 CYS A 102 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
25 CYS B 242 ? CYS B 522 ? CYS A 233 ? 1_555 CYS A 513 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
26 CYS B 372 ? CYS B 375 ? CYS A 363 ? 1_555 CYS A 366 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
27 CYS B 414 ? CYS B 419 ? CYS A 405 ? 1_555 CYS A 410 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
28 CYS B 504 ? CYS B 523 ? CYS A 495 ? 1_555 CYS A 514 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
29 CYS B 508 ? CYS B 526 ? CYS A 499 ? 1_555 CYS A 517 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 3 ? 
AA5 ? 8 ? 
AA6 ? 2 ? 
AA7 ? 2 ? 
AA8 ? 6 ? 
AA9 ? 2 ? 
AB1 ? 8 ? 
AB2 ? 2 ? 
AB3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? parallel      
AA5 1 2 ? parallel      
AA5 2 3 ? parallel      
AA5 3 4 ? parallel      
AA5 4 5 ? parallel      
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA5 7 8 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? parallel      
AA8 3 4 ? parallel      
AA8 4 5 ? parallel      
AA8 5 6 ? parallel      
AA9 1 2 ? anti-parallel 
AB1 1 2 ? parallel      
AB1 2 3 ? parallel      
AB1 3 4 ? parallel      
AB1 4 5 ? parallel      
AB1 5 6 ? anti-parallel 
AB1 6 7 ? anti-parallel 
AB1 7 8 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 37  ? MET A 38  ? ARG B 30  MET B 31  
AA1 2 TYR A 104 ? ASP A 108 ? TYR B 97  ASP B 101 
AA1 3 GLY A 45  ? PHE A 48  ? GLY B 38  PHE B 41  
AA2 1 GLY A 51  ? GLU A 52  ? GLY B 44  GLU B 45  
AA2 2 ARG A 71  ? PHE A 72  ? ARG B 64  PHE B 65  
AA3 1 ASP A 131 ? ALA A 133 ? ASP B 124 ALA B 126 
AA3 2 LEU B 130 ? PRO B 132 ? LEU A 121 PRO A 123 
AA4 1 VAL A 148 ? GLY A 150 ? VAL B 141 GLY B 143 
AA4 2 GLN A 171 ? SER A 173 ? GLN B 164 SER B 166 
AA4 3 PHE A 190 ? ARG A 192 ? PHE B 183 ARG B 185 
AA5 1 CYS A 243 ? GLU A 247 ? CYS B 236 GLU B 240 
AA5 2 TRP A 215 ? GLY A 220 ? TRP B 208 GLY B 213 
AA5 3 VAL A 277 ? PHE A 281 ? VAL B 270 PHE B 274 
AA5 4 VAL A 303 ? ALA A 306 ? VAL B 296 ALA B 299 
AA5 5 VAL A 328 ? GLN A 333 ? VAL B 321 GLN B 326 
AA5 6 TYR A 461 ? VAL A 467 ? TYR B 454 VAL B 460 
AA5 7 ARG A 474 ? PHE A 481 ? ARG B 467 PHE B 474 
AA5 8 ARG A 486 ? THR A 487 ? ARG B 479 THR B 480 
AA6 1 THR A 441 ? VAL A 444 ? THR B 434 VAL B 437 
AA6 2 LEU A 447 ? ARG A 450 ? LEU B 440 ARG B 443 
AA7 1 VAL A 518 ? LYS A 519 ? VAL B 511 LYS B 512 
AA7 2 CYS A 525 ? TYR A 526 ? CYS B 518 TYR B 519 
AA8 1 TYR B 37  ? LEU B 38  ? TYR A 28  LEU A 29  
AA8 2 TYR B 105 ? ASP B 109 ? TYR A 96  ASP A 100 
AA8 3 LEU B 43  ? PHE B 48  ? LEU A 34  PHE A 39  
AA8 4 VAL B 144 ? ILE B 148 ? VAL A 135 ILE A 139 
AA8 5 GLN B 170 ? THR B 172 ? GLN A 161 THR A 163 
AA8 6 LEU B 189 ? ARG B 191 ? LEU A 180 ARG A 182 
AA9 1 HIS B 51  ? ALA B 52  ? HIS A 42  ALA A 43  
AA9 2 GLU B 72  ? VAL B 73  ? GLU A 63  VAL A 64  
AB1 1 CYS B 242 ? LEU B 249 ? CYS A 233 LEU A 240 
AB1 2 TRP B 214 ? SER B 220 ? TRP A 205 SER A 211 
AB1 3 VAL B 281 ? PHE B 284 ? VAL A 272 PHE A 275 
AB1 4 ALA B 305 ? ALA B 309 ? ALA A 296 ALA A 300 
AB1 5 GLY B 329 ? ILE B 336 ? GLY A 320 ILE A 327 
AB1 6 LEU B 457 ? TRP B 462 ? LEU A 448 TRP A 453 
AB1 7 PHE B 471 ? TYR B 478 ? PHE A 462 TYR A 469 
AB1 8 GLN B 483 ? LYS B 485 ? GLN A 474 LYS A 476 
AB2 1 PHE B 438 ? THR B 439 ? PHE A 429 THR A 430 
AB2 2 GLN B 444 ? ILE B 445 ? GLN A 435 ILE A 436 
AB3 1 LYS B 515 ? PRO B 516 ? LYS A 506 PRO A 507 
AB3 2 PHE B 524 ? GLU B 525 ? PHE A 515 GLU A 516 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N MET A 38  ? N MET B 31  O TYR A 104 ? O TYR B 97  
AA1 2 3 O PHE A 107 ? O PHE B 100 N PHE A 48  ? N PHE B 41  
AA2 1 2 N GLU A 52  ? N GLU B 45  O ARG A 71  ? O ARG B 64  
AA3 1 2 N ILE A 132 ? N ILE B 125 O LEU B 131 ? O LEU A 122 
AA4 1 2 N GLY A 150 ? N GLY B 143 O VAL A 172 ? O VAL B 165 
AA4 2 3 N GLN A 171 ? N GLN B 164 O PHE A 191 ? O PHE B 184 
AA5 1 2 O ALA A 245 ? O ALA B 238 N VAL A 216 ? N VAL B 209 
AA5 2 3 N LEU A 219 ? N LEU B 212 O LEU A 279 ? O LEU B 272 
AA5 3 4 N VAL A 278 ? N VAL B 271 O VAL A 305 ? O VAL B 298 
AA5 4 5 N TRP A 304 ? N TRP B 297 O LEU A 329 ? O LEU B 322 
AA5 5 6 N LEU A 332 ? N LEU B 325 O ASP A 462 ? O ASP B 455 
AA5 6 7 N VAL A 467 ? N VAL B 460 O ARG A 474 ? O ARG B 467 
AA5 7 8 N ARG A 480 ? N ARG B 473 O ARG A 486 ? O ARG B 479 
AA6 1 2 N PHE A 442 ? N PHE B 435 O LEU A 449 ? O LEU B 442 
AA7 1 2 N LYS A 519 ? N LYS B 512 O CYS A 525 ? O CYS B 518 
AA8 1 2 N LEU B 38  ? N LEU A 29  O TYR B 105 ? O TYR A 96  
AA8 2 3 O VAL B 108 ? O VAL A 99  N GLY B 46  ? N GLY A 37  
AA8 3 4 N GLY B 45  ? N GLY A 36  O ILE B 148 ? O ILE A 139 
AA8 4 5 N VAL B 147 ? N VAL A 138 O ILE B 171 ? O ILE A 162 
AA8 5 6 N GLN B 170 ? N GLN A 161 O LEU B 190 ? O LEU A 181 
AA9 1 2 N ALA B 52  ? N ALA A 43  O GLU B 72  ? O GLU A 63  
AB1 1 2 O ALA B 244 ? O ALA A 235 N ILE B 215 ? N ILE A 206 
AB1 2 3 N LEU B 218 ? N LEU A 209 O VAL B 282 ? O VAL A 273 
AB1 3 4 N VAL B 281 ? N VAL A 272 O ILE B 308 ? O ILE A 299 
AB1 4 5 N TRP B 307 ? N TRP A 298 O LEU B 332 ? O LEU A 323 
AB1 5 6 N GLY B 333 ? N GLY A 324 O VAL B 460 ? O VAL A 451 
AB1 6 7 N GLN B 461 ? N GLN A 452 O GLN B 472 ? O GLN A 463 
AB1 7 8 N SER B 476 ? N SER A 467 O LYS B 485 ? O LYS A 476 
AB2 1 2 N PHE B 438 ? N PHE A 429 O ILE B 445 ? O ILE A 436 
AB3 1 2 N LYS B 515 ? N LYS A 506 O GLU B 525 ? O GLU A 516 
# 
_pdbx_entry_details.entry_id                   9NOV 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLN B 317 ? ? -95.49 31.35 
2 1 SER B 464 ? ? 58.03  16.82 
3 1 LEU A 89  ? ? 50.43  71.43 
4 1 ARG A 202 ? ? 61.38  60.09 
5 1 THR A 314 ? ? 66.73  -2.13 
6 1 LYS A 407 ? ? 59.32  19.29 
# 
_pdbx_molecule_features.prd_id    PRD_900090 
_pdbx_molecule_features.name      sucralose 
_pdbx_molecule_features.type      Oligosaccharide 
_pdbx_molecule_features.class     'Substrate analog' 
_pdbx_molecule_features.details   'oligosaccharide with reducing-end-to-reducing-end glycosidic bond' 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_900090 
_pdbx_molecule.asym_id       C 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9NOV 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9NOV 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.3 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               20540 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to sucralose' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1,2 
# 
_em_imaging.entry_id                        9NOV 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_vitrification.entry_id              9NOV 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9NOV 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 B MET -6  ? A MET 1   
2   1 Y 1 B LYS -5  ? A LYS 2   
3   1 Y 1 B THR -4  ? A THR 3   
4   1 Y 1 B ILE -3  ? A ILE 4   
5   1 Y 1 B ILE -2  ? A ILE 5   
6   1 Y 1 B ALA -1  ? A ALA 6   
7   1 Y 1 B LEU 0   ? A LEU 7   
8   1 Y 1 B SER 1   ? A SER 8   
9   1 Y 1 B TYR 2   ? A TYR 9   
10  1 Y 1 B ILE 3   ? A ILE 10  
11  1 Y 1 B PHE 4   ? A PHE 11  
12  1 Y 1 B CYS 5   ? A CYS 12  
13  1 Y 1 B LEU 6   ? A LEU 13  
14  1 Y 1 B VAL 7   ? A VAL 14  
15  1 Y 1 B PHE 8   ? A PHE 15  
16  1 Y 1 B ALA 9   ? A ALA 16  
17  1 Y 1 B ASP 10  ? A ASP 17  
18  1 Y 1 B TYR 11  ? A TYR 18  
19  1 Y 1 B LYS 12  ? A LYS 19  
20  1 Y 1 B ASP 13  ? A ASP 20  
21  1 Y 1 B ASP 14  ? A ASP 21  
22  1 Y 1 B ASP 15  ? A ASP 22  
23  1 Y 1 B ASP 16  ? A ASP 23  
24  1 Y 1 B LYS 17  ? A LYS 24  
25  1 Y 1 B ALA 18  ? A ALA 25  
26  1 Y 1 B ALA 19  ? A ALA 26  
27  1 Y 1 B ALA 20  ? A ALA 27  
28  1 Y 1 B ALA 21  ? A ALA 28  
29  1 Y 1 B PRO 22  ? A PRO 29  
30  1 Y 1 B GLU 47  ? A GLU 54  
31  1 Y 1 B GLU 48  ? A GLU 55  
32  1 Y 1 B ALA 49  ? A ALA 56  
33  1 Y 1 B GLY 50  ? A GLY 57  
34  1 Y 1 B LEU 51  ? A LEU 58  
35  1 Y 1 B ARG 52  ? A ARG 59  
36  1 Y 1 B SER 53  ? A SER 60  
37  1 Y 1 B ARG 247 ? A ARG 254 
38  1 Y 1 B ALA 248 ? A ALA 255 
39  1 Y 1 B ASP 249 ? A ASP 256 
40  1 Y 1 B ASP 250 ? A ASP 257 
41  1 Y 1 B SER 251 ? A SER 258 
42  1 Y 1 B ARG 252 ? A ARG 259 
43  1 Y 1 B LEU 253 ? A LEU 260 
44  1 Y 1 B GLY 254 ? A GLY 261 
45  1 Y 1 B GLY 355 ? A GLY 362 
46  1 Y 1 B GLU 356 ? A GLU 363 
47  1 Y 1 B ARG 357 ? A ARG 364 
48  1 Y 1 B GLU 358 ? A GLU 365 
49  1 Y 1 B GLN 359 ? A GLN 366 
50  1 Y 1 B GLY 360 ? A GLY 367 
51  1 Y 1 B LEU 361 ? A LEU 368 
52  1 Y 1 B GLU 362 ? A GLU 369 
53  1 Y 1 B GLU 363 ? A GLU 370 
54  1 Y 1 B ASP 364 ? A ASP 371 
55  1 Y 1 B VAL 365 ? A VAL 372 
56  1 Y 1 B VAL 366 ? A VAL 373 
57  1 Y 1 B GLY 367 ? A GLY 374 
58  1 Y 1 B GLN 504 ? A GLN 511 
59  1 Y 1 B GLU 505 ? A GLU 512 
60  1 Y 1 B GLY 506 ? A GLY 513 
61  1 Y 1 B GLN 507 ? A GLN 514 
62  1 Y 1 A MET -8  ? B MET 1   
63  1 Y 1 A LYS -7  ? B LYS 2   
64  1 Y 1 A THR -6  ? B THR 3   
65  1 Y 1 A ILE -5  ? B ILE 4   
66  1 Y 1 A ILE -4  ? B ILE 5   
67  1 Y 1 A ALA -3  ? B ALA 6   
68  1 Y 1 A LEU -2  ? B LEU 7   
69  1 Y 1 A SER -1  ? B SER 8   
70  1 Y 1 A TYR 0   ? B TYR 9   
71  1 Y 1 A ILE 1   ? B ILE 10  
72  1 Y 1 A PHE 2   ? B PHE 11  
73  1 Y 1 A CYS 3   ? B CYS 12  
74  1 Y 1 A LEU 4   ? B LEU 13  
75  1 Y 1 A VAL 5   ? B VAL 14  
76  1 Y 1 A PHE 6   ? B PHE 15  
77  1 Y 1 A ALA 7   ? B ALA 16  
78  1 Y 1 A TYR 8   ? B TYR 17  
79  1 Y 1 A PRO 9   ? B PRO 18  
80  1 Y 1 A TYR 10  ? B TYR 19  
81  1 Y 1 A ASP 11  ? B ASP 20  
82  1 Y 1 A VAL 12  ? B VAL 21  
83  1 Y 1 A PRO 13  ? B PRO 22  
84  1 Y 1 A ASP 14  ? B ASP 23  
85  1 Y 1 A TYR 15  ? B TYR 24  
86  1 Y 1 A ALA 16  ? B ALA 25  
87  1 Y 1 A ALA 17  ? B ALA 26  
88  1 Y 1 A ALA 18  ? B ALA 27  
89  1 Y 1 A ALA 19  ? B ALA 28  
90  1 Y 1 A GLU 20  ? B GLU 29  
91  1 Y 1 A PRO 21  ? B PRO 30  
92  1 Y 1 A ALA 22  ? B ALA 31  
93  1 Y 1 A GLU 23  ? B GLU 32  
94  1 Y 1 A ASN 24  ? B ASN 33  
95  1 Y 1 A GLY 47  ? B GLY 56  
96  1 Y 1 A ILE 48  ? B ILE 57  
97  1 Y 1 A VAL 49  ? B VAL 58  
98  1 Y 1 A HIS 50  ? B HIS 59  
99  1 Y 1 A LEU 51  ? B LEU 60  
100 1 Y 1 A PRO 343 ? B PRO 352 
101 1 Y 1 A GLN 344 ? B GLN 353 
102 1 Y 1 A ALA 345 ? B ALA 354 
103 1 Y 1 A GLY 346 ? B GLY 355 
104 1 Y 1 A PRO 347 ? B PRO 356 
105 1 Y 1 A PRO 348 ? B PRO 357 
106 1 Y 1 A PRO 349 ? B PRO 358 
107 1 Y 1 A LEU 350 ? B LEU 359 
108 1 Y 1 A SER 351 ? B SER 360 
109 1 Y 1 A ARG 352 ? B ARG 361 
110 1 Y 1 A THR 353 ? B THR 362 
111 1 Y 1 A SER 354 ? B SER 363 
112 1 Y 1 A GLN 355 ? B GLN 364 
113 1 Y 1 A SER 356 ? B SER 365 
114 1 Y 1 A TYR 357 ? B TYR 366 
115 1 Y 1 A GLN 500 ? B GLN 509 
116 1 Y 1 A SER 501 ? B SER 510 
117 1 Y 1 A GLY 502 ? B GLY 511 
118 1 Y 1 A GLN 503 ? B GLN 512 
119 1 Y 1 A LYS 504 ? B LYS 513 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
ILE N    N  N N 158 
ILE CA   C  N S 159 
ILE C    C  N N 160 
ILE O    O  N N 161 
ILE CB   C  N S 162 
ILE CG1  C  N N 163 
ILE CG2  C  N N 164 
ILE CD1  C  N N 165 
ILE OXT  O  N N 166 
ILE H    H  N N 167 
ILE H2   H  N N 168 
ILE HA   H  N N 169 
ILE HB   H  N N 170 
ILE HG12 H  N N 171 
ILE HG13 H  N N 172 
ILE HG21 H  N N 173 
ILE HG22 H  N N 174 
ILE HG23 H  N N 175 
ILE HD11 H  N N 176 
ILE HD12 H  N N 177 
ILE HD13 H  N N 178 
ILE HXT  H  N N 179 
LEU N    N  N N 180 
LEU CA   C  N S 181 
LEU C    C  N N 182 
LEU O    O  N N 183 
LEU CB   C  N N 184 
LEU CG   C  N N 185 
LEU CD1  C  N N 186 
LEU CD2  C  N N 187 
LEU OXT  O  N N 188 
LEU H    H  N N 189 
LEU H2   H  N N 190 
LEU HA   H  N N 191 
LEU HB2  H  N N 192 
LEU HB3  H  N N 193 
LEU HG   H  N N 194 
LEU HD11 H  N N 195 
LEU HD12 H  N N 196 
LEU HD13 H  N N 197 
LEU HD21 H  N N 198 
LEU HD22 H  N N 199 
LEU HD23 H  N N 200 
LEU HXT  H  N N 201 
LYS N    N  N N 202 
LYS CA   C  N S 203 
LYS C    C  N N 204 
LYS O    O  N N 205 
LYS CB   C  N N 206 
LYS CG   C  N N 207 
LYS CD   C  N N 208 
LYS CE   C  N N 209 
LYS NZ   N  N N 210 
LYS OXT  O  N N 211 
LYS H    H  N N 212 
LYS H2   H  N N 213 
LYS HA   H  N N 214 
LYS HB2  H  N N 215 
LYS HB3  H  N N 216 
LYS HG2  H  N N 217 
LYS HG3  H  N N 218 
LYS HD2  H  N N 219 
LYS HD3  H  N N 220 
LYS HE2  H  N N 221 
LYS HE3  H  N N 222 
LYS HZ1  H  N N 223 
LYS HZ2  H  N N 224 
LYS HZ3  H  N N 225 
LYS HXT  H  N N 226 
MET N    N  N N 227 
MET CA   C  N S 228 
MET C    C  N N 229 
MET O    O  N N 230 
MET CB   C  N N 231 
MET CG   C  N N 232 
MET SD   S  N N 233 
MET CE   C  N N 234 
MET OXT  O  N N 235 
MET H    H  N N 236 
MET H2   H  N N 237 
MET HA   H  N N 238 
MET HB2  H  N N 239 
MET HB3  H  N N 240 
MET HG2  H  N N 241 
MET HG3  H  N N 242 
MET HE1  H  N N 243 
MET HE2  H  N N 244 
MET HE3  H  N N 245 
MET HXT  H  N N 246 
NAG C1   C  N R 247 
NAG C2   C  N R 248 
NAG C3   C  N R 249 
NAG C4   C  N S 250 
NAG C5   C  N R 251 
NAG C6   C  N N 252 
NAG C7   C  N N 253 
NAG C8   C  N N 254 
NAG N2   N  N N 255 
NAG O1   O  N N 256 
NAG O3   O  N N 257 
NAG O4   O  N N 258 
NAG O5   O  N N 259 
NAG O6   O  N N 260 
NAG O7   O  N N 261 
NAG H1   H  N N 262 
NAG H2   H  N N 263 
NAG H3   H  N N 264 
NAG H4   H  N N 265 
NAG H5   H  N N 266 
NAG H61  H  N N 267 
NAG H62  H  N N 268 
NAG H81  H  N N 269 
NAG H82  H  N N 270 
NAG H83  H  N N 271 
NAG HN2  H  N N 272 
NAG HO1  H  N N 273 
NAG HO3  H  N N 274 
NAG HO4  H  N N 275 
NAG HO6  H  N N 276 
PHE N    N  N N 277 
PHE CA   C  N S 278 
PHE C    C  N N 279 
PHE O    O  N N 280 
PHE CB   C  N N 281 
PHE CG   C  Y N 282 
PHE CD1  C  Y N 283 
PHE CD2  C  Y N 284 
PHE CE1  C  Y N 285 
PHE CE2  C  Y N 286 
PHE CZ   C  Y N 287 
PHE OXT  O  N N 288 
PHE H    H  N N 289 
PHE H2   H  N N 290 
PHE HA   H  N N 291 
PHE HB2  H  N N 292 
PHE HB3  H  N N 293 
PHE HD1  H  N N 294 
PHE HD2  H  N N 295 
PHE HE1  H  N N 296 
PHE HE2  H  N N 297 
PHE HZ   H  N N 298 
PHE HXT  H  N N 299 
PRO N    N  N N 300 
PRO CA   C  N S 301 
PRO C    C  N N 302 
PRO O    O  N N 303 
PRO CB   C  N N 304 
PRO CG   C  N N 305 
PRO CD   C  N N 306 
PRO OXT  O  N N 307 
PRO H    H  N N 308 
PRO HA   H  N N 309 
PRO HB2  H  N N 310 
PRO HB3  H  N N 311 
PRO HG2  H  N N 312 
PRO HG3  H  N N 313 
PRO HD2  H  N N 314 
PRO HD3  H  N N 315 
PRO HXT  H  N N 316 
RRJ O1   O  N N 317 
RRJ C1   C  N S 318 
RRJ O5   O  N N 319 
RRJ C5   C  N R 320 
RRJ C6   C  N N 321 
RRJ O6   O  N N 322 
RRJ C4   C  N R 323 
RRJ CL4  CL N N 324 
RRJ C3   C  N R 325 
RRJ O3   O  N N 326 
RRJ C2   C  N R 327 
RRJ O2   O  N N 328 
RRJ H1   H  N N 329 
RRJ H5   H  N N 330 
RRJ H61  H  N N 331 
RRJ H62  H  N N 332 
RRJ HO6  H  N N 333 
RRJ H4   H  N N 334 
RRJ H3   H  N N 335 
RRJ HO3  H  N N 336 
RRJ H2   H  N N 337 
RRJ HO2  H  N N 338 
RRJ HO1  H  N N 339 
RRY O3   O  N N 340 
RRY C3   C  N S 341 
RRY C4   C  N S 342 
RRY O4   O  N N 343 
RRY C5   C  N S 344 
RRY C6   C  N N 345 
RRY CL6  CL N N 346 
RRY O5   O  N N 347 
RRY C2   C  N S 348 
RRY C1   C  N N 349 
RRY CL1  CL N N 350 
RRY O2   O  N N 351 
RRY HO3  H  N N 352 
RRY H3   H  N N 353 
RRY H4   H  N N 354 
RRY HO4  H  N N 355 
RRY H5   H  N N 356 
RRY H61  H  N N 357 
RRY H62  H  N N 358 
RRY H11  H  N N 359 
RRY H12  H  N N 360 
RRY HO2  H  N N 361 
SER N    N  N N 362 
SER CA   C  N S 363 
SER C    C  N N 364 
SER O    O  N N 365 
SER CB   C  N N 366 
SER OG   O  N N 367 
SER OXT  O  N N 368 
SER H    H  N N 369 
SER H2   H  N N 370 
SER HA   H  N N 371 
SER HB2  H  N N 372 
SER HB3  H  N N 373 
SER HG   H  N N 374 
SER HXT  H  N N 375 
THR N    N  N N 376 
THR CA   C  N S 377 
THR C    C  N N 378 
THR O    O  N N 379 
THR CB   C  N R 380 
THR OG1  O  N N 381 
THR CG2  C  N N 382 
THR OXT  O  N N 383 
THR H    H  N N 384 
THR H2   H  N N 385 
THR HA   H  N N 386 
THR HB   H  N N 387 
THR HG1  H  N N 388 
THR HG21 H  N N 389 
THR HG22 H  N N 390 
THR HG23 H  N N 391 
THR HXT  H  N N 392 
TRP N    N  N N 393 
TRP CA   C  N S 394 
TRP C    C  N N 395 
TRP O    O  N N 396 
TRP CB   C  N N 397 
TRP CG   C  Y N 398 
TRP CD1  C  Y N 399 
TRP CD2  C  Y N 400 
TRP NE1  N  Y N 401 
TRP CE2  C  Y N 402 
TRP CE3  C  Y N 403 
TRP CZ2  C  Y N 404 
TRP CZ3  C  Y N 405 
TRP CH2  C  Y N 406 
TRP OXT  O  N N 407 
TRP H    H  N N 408 
TRP H2   H  N N 409 
TRP HA   H  N N 410 
TRP HB2  H  N N 411 
TRP HB3  H  N N 412 
TRP HD1  H  N N 413 
TRP HE1  H  N N 414 
TRP HE3  H  N N 415 
TRP HZ2  H  N N 416 
TRP HZ3  H  N N 417 
TRP HH2  H  N N 418 
TRP HXT  H  N N 419 
TYR N    N  N N 420 
TYR CA   C  N S 421 
TYR C    C  N N 422 
TYR O    O  N N 423 
TYR CB   C  N N 424 
TYR CG   C  Y N 425 
TYR CD1  C  Y N 426 
TYR CD2  C  Y N 427 
TYR CE1  C  Y N 428 
TYR CE2  C  Y N 429 
TYR CZ   C  Y N 430 
TYR OH   O  N N 431 
TYR OXT  O  N N 432 
TYR H    H  N N 433 
TYR H2   H  N N 434 
TYR HA   H  N N 435 
TYR HB2  H  N N 436 
TYR HB3  H  N N 437 
TYR HD1  H  N N 438 
TYR HD2  H  N N 439 
TYR HE1  H  N N 440 
TYR HE2  H  N N 441 
TYR HH   H  N N 442 
TYR HXT  H  N N 443 
VAL N    N  N N 444 
VAL CA   C  N S 445 
VAL C    C  N N 446 
VAL O    O  N N 447 
VAL CB   C  N N 448 
VAL CG1  C  N N 449 
VAL CG2  C  N N 450 
VAL OXT  O  N N 451 
VAL H    H  N N 452 
VAL H2   H  N N 453 
VAL HA   H  N N 454 
VAL HB   H  N N 455 
VAL HG11 H  N N 456 
VAL HG12 H  N N 457 
VAL HG13 H  N N 458 
VAL HG21 H  N N 459 
VAL HG22 H  N N 460 
VAL HG23 H  N N 461 
VAL HXT  H  N N 462 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
RRJ O1  C1   sing N N 305 
RRJ C1  C2   sing N N 306 
RRJ C1  O5   sing N N 307 
RRJ O5  C5   sing N N 308 
RRJ C5  C4   sing N N 309 
RRJ C5  C6   sing N N 310 
RRJ C6  O6   sing N N 311 
RRJ C4  C3   sing N N 312 
RRJ C4  CL4  sing N N 313 
RRJ C3  C2   sing N N 314 
RRJ C3  O3   sing N N 315 
RRJ C2  O2   sing N N 316 
RRJ C1  H1   sing N N 317 
RRJ C5  H5   sing N N 318 
RRJ C6  H61  sing N N 319 
RRJ C6  H62  sing N N 320 
RRJ O6  HO6  sing N N 321 
RRJ C4  H4   sing N N 322 
RRJ C3  H3   sing N N 323 
RRJ O3  HO3  sing N N 324 
RRJ C2  H2   sing N N 325 
RRJ O2  HO2  sing N N 326 
RRJ O1  HO1  sing N N 327 
RRY O3  C3   sing N N 328 
RRY C3  C4   sing N N 329 
RRY C3  C2   sing N N 330 
RRY C4  O4   sing N N 331 
RRY C4  C5   sing N N 332 
RRY C5  C6   sing N N 333 
RRY C5  O5   sing N N 334 
RRY C6  CL6  sing N N 335 
RRY O5  C2   sing N N 336 
RRY C2  C1   sing N N 337 
RRY C2  O2   sing N N 338 
RRY C1  CL1  sing N N 339 
RRY O3  HO3  sing N N 340 
RRY C3  H3   sing N N 341 
RRY C4  H4   sing N N 342 
RRY O4  HO4  sing N N 343 
RRY C5  H5   sing N N 344 
RRY C6  H61  sing N N 345 
RRY C6  H62  sing N N 346 
RRY C1  H11  sing N N 347 
RRY C1  H12  sing N N 348 
RRY O2  HO2  sing N N 349 
SER N   CA   sing N N 350 
SER N   H    sing N N 351 
SER N   H2   sing N N 352 
SER CA  C    sing N N 353 
SER CA  CB   sing N N 354 
SER CA  HA   sing N N 355 
SER C   O    doub N N 356 
SER C   OXT  sing N N 357 
SER CB  OG   sing N N 358 
SER CB  HB2  sing N N 359 
SER CB  HB3  sing N N 360 
SER OG  HG   sing N N 361 
SER OXT HXT  sing N N 362 
THR N   CA   sing N N 363 
THR N   H    sing N N 364 
THR N   H2   sing N N 365 
THR CA  C    sing N N 366 
THR CA  CB   sing N N 367 
THR CA  HA   sing N N 368 
THR C   O    doub N N 369 
THR C   OXT  sing N N 370 
THR CB  OG1  sing N N 371 
THR CB  CG2  sing N N 372 
THR CB  HB   sing N N 373 
THR OG1 HG1  sing N N 374 
THR CG2 HG21 sing N N 375 
THR CG2 HG22 sing N N 376 
THR CG2 HG23 sing N N 377 
THR OXT HXT  sing N N 378 
TRP N   CA   sing N N 379 
TRP N   H    sing N N 380 
TRP N   H2   sing N N 381 
TRP CA  C    sing N N 382 
TRP CA  CB   sing N N 383 
TRP CA  HA   sing N N 384 
TRP C   O    doub N N 385 
TRP C   OXT  sing N N 386 
TRP CB  CG   sing N N 387 
TRP CB  HB2  sing N N 388 
TRP CB  HB3  sing N N 389 
TRP CG  CD1  doub Y N 390 
TRP CG  CD2  sing Y N 391 
TRP CD1 NE1  sing Y N 392 
TRP CD1 HD1  sing N N 393 
TRP CD2 CE2  doub Y N 394 
TRP CD2 CE3  sing Y N 395 
TRP NE1 CE2  sing Y N 396 
TRP NE1 HE1  sing N N 397 
TRP CE2 CZ2  sing Y N 398 
TRP CE3 CZ3  doub Y N 399 
TRP CE3 HE3  sing N N 400 
TRP CZ2 CH2  doub Y N 401 
TRP CZ2 HZ2  sing N N 402 
TRP CZ3 CH2  sing Y N 403 
TRP CZ3 HZ3  sing N N 404 
TRP CH2 HH2  sing N N 405 
TRP OXT HXT  sing N N 406 
TYR N   CA   sing N N 407 
TYR N   H    sing N N 408 
TYR N   H2   sing N N 409 
TYR CA  C    sing N N 410 
TYR CA  CB   sing N N 411 
TYR CA  HA   sing N N 412 
TYR C   O    doub N N 413 
TYR C   OXT  sing N N 414 
TYR CB  CG   sing N N 415 
TYR CB  HB2  sing N N 416 
TYR CB  HB3  sing N N 417 
TYR CG  CD1  doub Y N 418 
TYR CG  CD2  sing Y N 419 
TYR CD1 CE1  sing Y N 420 
TYR CD1 HD1  sing N N 421 
TYR CD2 CE2  doub Y N 422 
TYR CD2 HD2  sing N N 423 
TYR CE1 CZ   doub Y N 424 
TYR CE1 HE1  sing N N 425 
TYR CE2 CZ   sing Y N 426 
TYR CE2 HE2  sing N N 427 
TYR CZ  OH   sing N N 428 
TYR OH  HH   sing N N 429 
TYR OXT HXT  sing N N 430 
VAL N   CA   sing N N 431 
VAL N   H    sing N N 432 
VAL N   H2   sing N N 433 
VAL CA  C    sing N N 434 
VAL CA  CB   sing N N 435 
VAL CA  HA   sing N N 436 
VAL C   O    doub N N 437 
VAL C   OXT  sing N N 438 
VAL CB  CG1  sing N N 439 
VAL CB  CG2  sing N N 440 
VAL CB  HB   sing N N 441 
VAL CG1 HG11 sing N N 442 
VAL CG1 HG12 sing N N 443 
VAL CG1 HG13 sing N N 444 
VAL CG2 HG21 sing N N 445 
VAL CG2 HG22 sing N N 446 
VAL CG2 HG23 sing N N 447 
VAL OXT HXT  sing N N 448 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-03-10 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9NOV 
_em_admin.last_update        2025-05-21 
_em_admin.map_release_date   2025-05-14 
_em_admin.title              'Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to sucralose' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         59 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
_em_software.reference_DOI 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? ? 
MASKING                         ? 3  ? ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Howard Hughes Medical Institute (HHMI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 RRY 1 n 
3 RRJ 2 n 
# 
_atom_sites.entry_id                    9NOV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LEU A 1 30  ? 189.599 214.091 98.923  1.00 108.11 ? 23  LEU B N   1 
ATOM   2    C  CA  . LEU A 1 30  ? 190.906 213.611 99.348  1.00 109.99 ? 23  LEU B CA  1 
ATOM   3    C  C   . LEU A 1 30  ? 191.346 212.408 98.522  1.00 113.30 ? 23  LEU B C   1 
ATOM   4    O  O   . LEU A 1 30  ? 192.496 211.982 98.604  1.00 115.64 ? 23  LEU B O   1 
ATOM   5    C  CB  . LEU A 1 30  ? 190.882 213.248 100.830 1.00 107.51 ? 23  LEU B CB  1 
ATOM   6    C  CG  . LEU A 1 30  ? 192.226 213.275 101.555 1.00 109.21 ? 23  LEU B CG  1 
ATOM   7    C  CD1 . LEU A 1 30  ? 193.019 214.499 101.148 1.00 108.19 ? 23  LEU B CD1 1 
ATOM   8    C  CD2 . LEU A 1 30  ? 192.019 213.250 103.052 1.00 113.13 ? 23  LEU B CD2 1 
ATOM   9    N  N   . CYS A 1 31  ? 190.412 211.870 97.735  1.00 111.58 ? 24  CYS B N   1 
ATOM   10   C  CA  . CYS A 1 31  ? 190.646 210.716 96.858  1.00 111.00 ? 24  CYS B CA  1 
ATOM   11   C  C   . CYS A 1 31  ? 191.350 209.575 97.588  1.00 104.19 ? 24  CYS B C   1 
ATOM   12   O  O   . CYS A 1 31  ? 192.165 208.853 97.011  1.00 99.59  ? 24  CYS B O   1 
ATOM   13   C  CB  . CYS A 1 31  ? 191.411 211.116 95.590  1.00 118.23 ? 24  CYS B CB  1 
ATOM   14   S  SG  . CYS A 1 31  ? 193.183 211.425 95.740  1.00 129.69 ? 24  CYS B SG  1 
ATOM   15   N  N   . LEU A 1 32  ? 191.037 209.405 98.872  1.00 103.83 ? 25  LEU B N   1 
ATOM   16   C  CA  . LEU A 1 32  ? 191.537 208.251 99.608  1.00 98.41  ? 25  LEU B CA  1 
ATOM   17   C  C   . LEU A 1 32  ? 190.759 206.986 99.283  1.00 95.04  ? 25  LEU B C   1 
ATOM   18   O  O   . LEU A 1 32  ? 191.348 205.904 99.218  1.00 96.45  ? 25  LEU B O   1 
ATOM   19   C  CB  . LEU A 1 32  ? 191.486 208.520 101.110 1.00 95.38  ? 25  LEU B CB  1 
ATOM   20   C  CG  . LEU A 1 32  ? 192.472 207.722 101.959 1.00 88.37  ? 25  LEU B CG  1 
ATOM   21   C  CD1 . LEU A 1 32  ? 193.887 207.937 101.467 1.00 87.58  ? 25  LEU B CD1 1 
ATOM   22   C  CD2 . LEU A 1 32  ? 192.349 208.131 103.410 1.00 92.11  ? 25  LEU B CD2 1 
ATOM   23   N  N   . SER A 1 33  ? 189.446 207.100 99.070  1.00 94.40  ? 26  SER B N   1 
ATOM   24   C  CA  . SER A 1 33  ? 188.631 205.914 98.835  1.00 94.82  ? 26  SER B CA  1 
ATOM   25   C  C   . SER A 1 33  ? 188.981 205.236 97.520  1.00 93.41  ? 26  SER B C   1 
ATOM   26   O  O   . SER A 1 33  ? 188.825 204.017 97.394  1.00 92.84  ? 26  SER B O   1 
ATOM   27   C  CB  . SER A 1 33  ? 187.151 206.282 98.862  1.00 101.77 ? 26  SER B CB  1 
ATOM   28   O  OG  . SER A 1 33  ? 186.730 206.567 100.182 1.00 105.11 ? 26  SER B OG  1 
ATOM   29   N  N   . GLN A 1 34  ? 189.448 205.997 96.532  1.00 91.30  ? 27  GLN B N   1 
ATOM   30   C  CA  . GLN A 1 34  ? 189.840 205.392 95.267  1.00 92.72  ? 27  GLN B CA  1 
ATOM   31   C  C   . GLN A 1 34  ? 191.028 204.455 95.422  1.00 92.18  ? 27  GLN B C   1 
ATOM   32   O  O   . GLN A 1 34  ? 191.230 203.587 94.568  1.00 90.06  ? 27  GLN B O   1 
ATOM   33   C  CB  . GLN A 1 34  ? 190.165 206.477 94.242  1.00 98.01  ? 27  GLN B CB  1 
ATOM   34   C  CG  . GLN A 1 34  ? 190.012 206.025 92.803  1.00 107.43 ? 27  GLN B CG  1 
ATOM   35   C  CD  . GLN A 1 34  ? 190.110 207.172 91.823  1.00 113.99 ? 27  GLN B CD  1 
ATOM   36   O  OE1 . GLN A 1 34  ? 190.289 208.323 92.216  1.00 120.46 ? 27  GLN B OE1 1 
ATOM   37   N  NE2 . GLN A 1 34  ? 189.995 206.863 90.537  1.00 108.59 ? 27  GLN B NE2 1 
ATOM   38   N  N   . GLN A 1 35  ? 191.814 204.609 96.484  1.00 91.81  ? 28  GLN B N   1 
ATOM   39   C  CA  . GLN A 1 35  ? 192.957 203.744 96.740  1.00 86.78  ? 28  GLN B CA  1 
ATOM   40   C  C   . GLN A 1 35  ? 192.591 202.496 97.528  1.00 86.40  ? 28  GLN B C   1 
ATOM   41   O  O   . GLN A 1 35  ? 193.469 201.667 97.785  1.00 87.94  ? 28  GLN B O   1 
ATOM   42   C  CB  . GLN A 1 35  ? 194.046 204.509 97.490  1.00 87.08  ? 28  GLN B CB  1 
ATOM   43   C  CG  . GLN A 1 35  ? 194.934 205.343 96.599  1.00 93.90  ? 28  GLN B CG  1 
ATOM   44   C  CD  . GLN A 1 35  ? 195.381 206.618 97.270  1.00 102.07 ? 28  GLN B CD  1 
ATOM   45   O  OE1 . GLN A 1 35  ? 196.565 206.953 97.268  1.00 108.80 ? 28  GLN B OE1 1 
ATOM   46   N  NE2 . GLN A 1 35  ? 194.433 207.345 97.845  1.00 100.13 ? 28  GLN B NE2 1 
ATOM   47   N  N   . LEU A 1 36  ? 191.329 202.347 97.928  1.00 84.76  ? 29  LEU B N   1 
ATOM   48   C  CA  . LEU A 1 36  ? 190.908 201.161 98.659  1.00 78.13  ? 29  LEU B CA  1 
ATOM   49   C  C   . LEU A 1 36  ? 190.838 199.920 97.782  1.00 77.31  ? 29  LEU B C   1 
ATOM   50   O  O   . LEU A 1 36  ? 190.693 198.818 98.316  1.00 77.01  ? 29  LEU B O   1 
ATOM   51   C  CB  . LEU A 1 36  ? 189.552 201.406 99.315  1.00 80.75  ? 29  LEU B CB  1 
ATOM   52   C  CG  . LEU A 1 36  ? 189.533 202.483 100.397 1.00 82.28  ? 29  LEU B CG  1 
ATOM   53   C  CD1 . LEU A 1 36  ? 188.304 202.340 101.274 1.00 83.64  ? 29  LEU B CD1 1 
ATOM   54   C  CD2 . LEU A 1 36  ? 190.797 202.417 101.233 1.00 75.93  ? 29  LEU B CD2 1 
ATOM   55   N  N   . ARG A 1 37  ? 190.925 200.067 96.465  1.00 79.66  ? 30  ARG B N   1 
ATOM   56   C  CA  . ARG A 1 37  ? 190.908 198.943 95.541  1.00 78.36  ? 30  ARG B CA  1 
ATOM   57   C  C   . ARG A 1 37  ? 192.066 199.084 94.567  1.00 78.89  ? 30  ARG B C   1 
ATOM   58   O  O   . ARG A 1 37  ? 192.251 200.148 93.972  1.00 83.51  ? 30  ARG B O   1 
ATOM   59   C  CB  . ARG A 1 37  ? 189.583 198.878 94.782  1.00 80.21  ? 30  ARG B CB  1 
ATOM   60   C  CG  . ARG A 1 37  ? 189.564 197.892 93.634  1.00 80.87  ? 30  ARG B CG  1 
ATOM   61   C  CD  . ARG A 1 37  ? 188.184 197.291 93.463  1.00 83.60  ? 30  ARG B CD  1 
ATOM   62   N  NE  . ARG A 1 37  ? 187.168 198.317 93.270  1.00 91.19  ? 30  ARG B NE  1 
ATOM   63   C  CZ  . ARG A 1 37  ? 186.884 198.882 92.105  1.00 88.89  ? 30  ARG B CZ  1 
ATOM   64   N  NH1 . ARG A 1 37  ? 187.520 198.540 90.998  1.00 87.52  ? 30  ARG B NH1 1 
ATOM   65   N  NH2 . ARG A 1 37  ? 185.936 199.813 92.050  1.00 80.64  ? 30  ARG B NH2 1 
ATOM   66   N  N   . MET A 1 38  ? 192.840 198.016 94.403  1.00 75.42  ? 31  MET B N   1 
ATOM   67   C  CA  . MET A 1 38  ? 193.964 198.021 93.477  1.00 78.17  ? 31  MET B CA  1 
ATOM   68   C  C   . MET A 1 38  ? 194.052 196.667 92.791  1.00 77.86  ? 31  MET B C   1 
ATOM   69   O  O   . MET A 1 38  ? 193.997 195.628 93.454  1.00 75.51  ? 31  MET B O   1 
ATOM   70   C  CB  . MET A 1 38  ? 195.273 198.344 94.205  1.00 81.55  ? 31  MET B CB  1 
ATOM   71   C  CG  . MET A 1 38  ? 196.493 198.395 93.305  1.00 89.75  ? 31  MET B CG  1 
ATOM   72   S  SD  . MET A 1 38  ? 198.035 198.427 94.238  1.00 107.29 ? 31  MET B SD  1 
ATOM   73   C  CE  . MET A 1 38  ? 199.146 197.618 93.091  1.00 92.81  ? 31  MET B CE  1 
ATOM   74   N  N   . LYS A 1 39  ? 194.188 196.684 91.470  1.00 79.70  ? 32  LYS B N   1 
ATOM   75   C  CA  . LYS A 1 39  ? 194.233 195.457 90.692  1.00 84.32  ? 32  LYS B CA  1 
ATOM   76   C  C   . LYS A 1 39  ? 195.598 194.786 90.802  1.00 85.92  ? 32  LYS B C   1 
ATOM   77   O  O   . LYS A 1 39  ? 196.601 195.405 91.164  1.00 84.76  ? 32  LYS B O   1 
ATOM   78   C  CB  . LYS A 1 39  ? 193.914 195.738 89.223  1.00 83.11  ? 32  LYS B CB  1 
ATOM   79   C  CG  . LYS A 1 39  ? 192.485 196.181 88.946  1.00 83.54  ? 32  LYS B CG  1 
ATOM   80   C  CD  . LYS A 1 39  ? 191.501 195.622 89.962  1.00 80.72  ? 32  LYS B CD  1 
ATOM   81   C  CE  . LYS A 1 39  ? 190.071 195.843 89.502  1.00 84.92  ? 32  LYS B CE  1 
ATOM   82   N  NZ  . LYS A 1 39  ? 189.142 196.059 90.637  1.00 83.84  ? 32  LYS B NZ  1 
ATOM   83   N  N   . GLY A 1 40  ? 195.621 193.500 90.477  1.00 84.58  ? 33  GLY B N   1 
ATOM   84   C  CA  . GLY A 1 40  ? 196.854 192.738 90.515  1.00 82.20  ? 33  GLY B CA  1 
ATOM   85   C  C   . GLY A 1 40  ? 196.593 191.300 90.131  1.00 83.35  ? 33  GLY B C   1 
ATOM   86   O  O   . GLY A 1 40  ? 195.453 190.891 89.894  1.00 85.61  ? 33  GLY B O   1 
ATOM   87   N  N   . ASP A 1 41  ? 197.683 190.530 90.068  1.00 84.20  ? 34  ASP B N   1 
ATOM   88   C  CA  . ASP A 1 41  ? 197.573 189.122 89.703  1.00 83.96  ? 34  ASP B CA  1 
ATOM   89   C  C   . ASP A 1 41  ? 196.782 188.338 90.739  1.00 83.58  ? 34  ASP B C   1 
ATOM   90   O  O   . ASP A 1 41  ? 195.938 187.506 90.386  1.00 84.37  ? 34  ASP B O   1 
ATOM   91   C  CB  . ASP A 1 41  ? 198.962 188.512 89.527  1.00 84.21  ? 34  ASP B CB  1 
ATOM   92   C  CG  . ASP A 1 41  ? 199.666 189.016 88.289  1.00 89.52  ? 34  ASP B CG  1 
ATOM   93   O  OD1 . ASP A 1 41  ? 199.448 188.440 87.203  1.00 91.19  ? 34  ASP B OD1 1 
ATOM   94   O  OD2 . ASP A 1 41  ? 200.444 189.985 88.401  1.00 91.08  ? 34  ASP B OD2 1 
ATOM   95   N  N   . TYR A 1 42  ? 197.041 188.582 92.022  1.00 80.83  ? 35  TYR B N   1 
ATOM   96   C  CA  . TYR A 1 42  ? 196.374 187.875 93.114  1.00 79.34  ? 35  TYR B CA  1 
ATOM   97   C  C   . TYR A 1 42  ? 195.889 188.917 94.111  1.00 77.96  ? 35  TYR B C   1 
ATOM   98   O  O   . TYR A 1 42  ? 196.630 189.319 95.010  1.00 79.74  ? 35  TYR B O   1 
ATOM   99   C  CB  . TYR A 1 42  ? 197.304 186.865 93.770  1.00 78.37  ? 35  TYR B CB  1 
ATOM   100  C  CG  . TYR A 1 42  ? 197.686 185.720 92.870  1.00 82.93  ? 35  TYR B CG  1 
ATOM   101  C  CD1 . TYR A 1 42  ? 197.050 184.495 92.969  1.00 86.54  ? 35  TYR B CD1 1 
ATOM   102  C  CD2 . TYR A 1 42  ? 198.695 185.859 91.931  1.00 85.16  ? 35  TYR B CD2 1 
ATOM   103  C  CE1 . TYR A 1 42  ? 197.398 183.447 92.150  1.00 93.49  ? 35  TYR B CE1 1 
ATOM   104  C  CE2 . TYR A 1 42  ? 199.050 184.816 91.109  1.00 92.66  ? 35  TYR B CE2 1 
ATOM   105  C  CZ  . TYR A 1 42  ? 198.399 183.612 91.222  1.00 96.71  ? 35  TYR B CZ  1 
ATOM   106  O  OH  . TYR A 1 42  ? 198.752 182.566 90.402  1.00 97.85  ? 35  TYR B OH  1 
ATOM   107  N  N   . VAL A 1 43  ? 194.641 189.353 93.955  1.00 74.10  ? 36  VAL B N   1 
ATOM   108  C  CA  . VAL A 1 43  ? 194.110 190.344 94.873  1.00 70.28  ? 36  VAL B CA  1 
ATOM   109  C  C   . VAL A 1 43  ? 193.869 189.708 96.237  1.00 64.26  ? 36  VAL B C   1 
ATOM   110  O  O   . VAL A 1 43  ? 193.699 188.493 96.374  1.00 65.47  ? 36  VAL B O   1 
ATOM   111  C  CB  . VAL A 1 43  ? 192.824 190.973 94.316  1.00 73.68  ? 36  VAL B CB  1 
ATOM   112  C  CG1 . VAL A 1 43  ? 192.974 191.250 92.832  1.00 73.67  ? 36  VAL B CG1 1 
ATOM   113  C  CG2 . VAL A 1 43  ? 191.641 190.070 94.571  1.00 74.54  ? 36  VAL B CG2 1 
ATOM   114  N  N   . LEU A 1 44  ? 193.874 190.547 97.263  1.00 64.45  ? 37  LEU B N   1 
ATOM   115  C  CA  . LEU A 1 44  ? 193.596 190.129 98.625  1.00 59.33  ? 37  LEU B CA  1 
ATOM   116  C  C   . LEU A 1 44  ? 192.268 190.720 99.075  1.00 61.15  ? 37  LEU B C   1 
ATOM   117  O  O   . LEU A 1 44  ? 191.728 191.635 98.453  1.00 69.70  ? 37  LEU B O   1 
ATOM   118  C  CB  . LEU A 1 44  ? 194.707 190.572 99.579  1.00 56.19  ? 37  LEU B CB  1 
ATOM   119  C  CG  . LEU A 1 44  ? 196.023 189.804 99.498  1.00 54.94  ? 37  LEU B CG  1 
ATOM   120  C  CD1 . LEU A 1 44  ? 197.105 190.521 100.276 1.00 54.71  ? 37  LEU B CD1 1 
ATOM   121  C  CD2 . LEU A 1 44  ? 195.837 188.404 100.013 1.00 55.13  ? 37  LEU B CD2 1 
ATOM   122  N  N   . GLY A 1 45  ? 191.742 190.180 100.165 1.00 57.23  ? 38  GLY B N   1 
ATOM   123  C  CA  . GLY A 1 45  ? 190.530 190.693 100.759 1.00 56.79  ? 38  GLY B CA  1 
ATOM   124  C  C   . GLY A 1 45  ? 190.838 191.680 101.868 1.00 57.31  ? 38  GLY B C   1 
ATOM   125  O  O   . GLY A 1 45  ? 191.978 191.862 102.275 1.00 60.98  ? 38  GLY B O   1 
ATOM   126  N  N   . GLY A 1 46  ? 189.788 192.333 102.348 1.00 54.69  ? 39  GLY B N   1 
ATOM   127  C  CA  . GLY A 1 46  ? 189.940 193.233 103.472 1.00 51.39  ? 39  GLY B CA  1 
ATOM   128  C  C   . GLY A 1 46  ? 188.638 193.484 104.196 1.00 56.75  ? 39  GLY B C   1 
ATOM   129  O  O   . GLY A 1 46  ? 187.637 193.836 103.570 1.00 68.21  ? 39  GLY B O   1 
ATOM   130  N  N   . LEU A 1 47  ? 188.633 193.306 105.512 1.00 50.86  ? 40  LEU B N   1 
ATOM   131  C  CA  . LEU A 1 47  ? 187.469 193.597 106.341 1.00 55.82  ? 40  LEU B CA  1 
ATOM   132  C  C   . LEU A 1 47  ? 187.937 194.462 107.500 1.00 62.79  ? 40  LEU B C   1 
ATOM   133  O  O   . LEU A 1 47  ? 188.605 193.972 108.413 1.00 69.18  ? 40  LEU B O   1 
ATOM   134  C  CB  . LEU A 1 47  ? 186.805 192.317 106.842 1.00 55.04  ? 40  LEU B CB  1 
ATOM   135  C  CG  . LEU A 1 47  ? 186.351 191.316 105.783 1.00 53.59  ? 40  LEU B CG  1 
ATOM   136  C  CD1 . LEU A 1 47  ? 185.773 190.083 106.441 1.00 55.69  ? 40  LEU B CD1 1 
ATOM   137  C  CD2 . LEU A 1 47  ? 185.335 191.946 104.864 1.00 53.66  ? 40  LEU B CD2 1 
ATOM   138  N  N   . PHE A 1 48  ? 187.598 195.743 107.460 1.00 60.72  ? 41  PHE B N   1 
ATOM   139  C  CA  . PHE A 1 48  ? 188.079 196.699 108.439 1.00 61.48  ? 41  PHE B CA  1 
ATOM   140  C  C   . PHE A 1 48  ? 186.909 197.469 109.028 1.00 68.75  ? 41  PHE B C   1 
ATOM   141  O  O   . PHE A 1 48  ? 185.892 197.663 108.359 1.00 73.19  ? 41  PHE B O   1 
ATOM   142  C  CB  . PHE A 1 48  ? 189.066 197.687 107.804 1.00 62.27  ? 41  PHE B CB  1 
ATOM   143  C  CG  . PHE A 1 48  ? 190.332 197.054 107.312 1.00 58.62  ? 41  PHE B CG  1 
ATOM   144  C  CD1 . PHE A 1 48  ? 190.337 196.272 106.178 1.00 60.66  ? 41  PHE B CD1 1 
ATOM   145  C  CD2 . PHE A 1 48  ? 191.522 197.265 107.969 1.00 59.09  ? 41  PHE B CD2 1 
ATOM   146  C  CE1 . PHE A 1 48  ? 191.497 195.700 105.725 1.00 60.30  ? 41  PHE B CE1 1 
ATOM   147  C  CE2 . PHE A 1 48  ? 192.684 196.695 107.519 1.00 58.84  ? 41  PHE B CE2 1 
ATOM   148  C  CZ  . PHE A 1 48  ? 192.672 195.913 106.396 1.00 58.51  ? 41  PHE B CZ  1 
ATOM   149  N  N   . PRO A 1 49  ? 187.022 197.914 110.275 1.00 69.30  ? 42  PRO B N   1 
ATOM   150  C  CA  . PRO A 1 49  ? 185.981 198.768 110.872 1.00 72.79  ? 42  PRO B CA  1 
ATOM   151  C  C   . PRO A 1 49  ? 186.133 200.231 110.468 1.00 81.06  ? 42  PRO B C   1 
ATOM   152  O  O   . PRO A 1 49  ? 186.371 201.113 111.296 1.00 87.11  ? 42  PRO B O   1 
ATOM   153  C  CB  . PRO A 1 49  ? 186.197 198.549 112.378 1.00 70.95  ? 42  PRO B CB  1 
ATOM   154  C  CG  . PRO A 1 49  ? 187.233 197.473 112.510 1.00 71.41  ? 42  PRO B CG  1 
ATOM   155  C  CD  . PRO A 1 49  ? 188.027 197.514 111.265 1.00 71.19  ? 42  PRO B CD  1 
ATOM   156  N  N   . LEU A 1 50  ? 185.998 200.495 109.167 1.00 81.50  ? 43  LEU B N   1 
ATOM   157  C  CA  . LEU A 1 50  ? 186.168 201.856 108.667 1.00 82.89  ? 43  LEU B CA  1 
ATOM   158  C  C   . LEU A 1 50  ? 185.106 202.790 109.230 1.00 89.34  ? 43  LEU B C   1 
ATOM   159  O  O   . LEU A 1 50  ? 185.406 203.932 109.596 1.00 94.97  ? 43  LEU B O   1 
ATOM   160  C  CB  . LEU A 1 50  ? 186.130 201.867 107.141 1.00 81.61  ? 43  LEU B CB  1 
ATOM   161  C  CG  . LEU A 1 50  ? 187.266 201.143 106.421 1.00 78.29  ? 43  LEU B CG  1 
ATOM   162  C  CD1 . LEU A 1 50  ? 187.056 201.193 104.926 1.00 83.76  ? 43  LEU B CD1 1 
ATOM   163  C  CD2 . LEU A 1 50  ? 188.599 201.752 106.782 1.00 76.01  ? 43  LEU B CD2 1 
ATOM   164  N  N   . GLY A 1 51  ? 183.861 202.325 109.312 1.00 89.11  ? 44  GLY B N   1 
ATOM   165  C  CA  . GLY A 1 51  ? 182.776 203.158 109.773 1.00 98.79  ? 44  GLY B CA  1 
ATOM   166  C  C   . GLY A 1 51  ? 181.971 202.471 110.858 1.00 102.88 ? 44  GLY B C   1 
ATOM   167  O  O   . GLY A 1 51  ? 182.018 201.254 111.027 1.00 102.05 ? 44  GLY B O   1 
ATOM   168  N  N   . GLU A 1 52  ? 181.229 203.288 111.600 1.00 106.65 ? 45  GLU B N   1 
ATOM   169  C  CA  . GLU A 1 52  ? 180.335 202.818 112.646 1.00 107.24 ? 45  GLU B CA  1 
ATOM   170  C  C   . GLU A 1 52  ? 178.948 203.400 112.413 1.00 110.50 ? 45  GLU B C   1 
ATOM   171  O  O   . GLU A 1 52  ? 178.745 204.254 111.547 1.00 111.66 ? 45  GLU B O   1 
ATOM   172  C  CB  . GLU A 1 52  ? 180.847 203.201 114.040 1.00 108.84 ? 45  GLU B CB  1 
ATOM   173  C  CG  . GLU A 1 52  ? 182.358 203.259 114.158 1.00 110.13 ? 45  GLU B CG  1 
ATOM   174  C  CD  . GLU A 1 52  ? 182.814 203.993 115.404 1.00 119.71 ? 45  GLU B CD  1 
ATOM   175  O  OE1 . GLU A 1 52  ? 181.968 204.631 116.064 1.00 122.92 ? 45  GLU B OE1 1 
ATOM   176  O  OE2 . GLU A 1 52  ? 184.020 203.932 115.723 1.00 122.59 ? 45  GLU B OE2 1 
ATOM   177  N  N   . ALA A 1 53  ? 177.987 202.929 113.200 1.00 109.99 ? 46  ALA B N   1 
ATOM   178  C  CA  . ALA A 1 53  ? 176.605 203.377 113.073 1.00 107.68 ? 46  ALA B CA  1 
ATOM   179  C  C   . ALA A 1 53  ? 176.442 204.818 113.540 1.00 107.52 ? 46  ALA B C   1 
ATOM   180  O  O   . ALA A 1 53  ? 175.323 205.291 113.735 1.00 104.87 ? 46  ALA B O   1 
ATOM   181  C  CB  . ALA A 1 53  ? 175.678 202.461 113.856 1.00 102.52 ? 46  ALA B CB  1 
ATOM   182  N  N   . ARG A 1 61  ? 165.271 197.970 110.474 1.00 99.03  ? 54  ARG B N   1 
ATOM   183  C  CA  . ARG A 1 61  ? 165.225 197.648 109.053 1.00 104.03 ? 54  ARG B CA  1 
ATOM   184  C  C   . ARG A 1 61  ? 164.115 196.645 108.755 1.00 109.11 ? 54  ARG B C   1 
ATOM   185  O  O   . ARG A 1 61  ? 164.190 195.484 109.155 1.00 107.94 ? 54  ARG B O   1 
ATOM   186  C  CB  . ARG A 1 61  ? 166.572 197.097 108.586 1.00 102.17 ? 54  ARG B CB  1 
ATOM   187  C  CG  . ARG A 1 61  ? 167.273 196.226 109.612 1.00 104.70 ? 54  ARG B CG  1 
ATOM   188  C  CD  . ARG A 1 61  ? 168.691 195.903 109.183 1.00 105.59 ? 54  ARG B CD  1 
ATOM   189  N  NE  . ARG A 1 61  ? 168.722 195.197 107.908 1.00 106.76 ? 54  ARG B NE  1 
ATOM   190  C  CZ  . ARG A 1 61  ? 168.661 193.879 107.778 1.00 101.34 ? 54  ARG B CZ  1 
ATOM   191  N  NH1 . ARG A 1 61  ? 168.557 193.085 108.830 1.00 98.44  ? 54  ARG B NH1 1 
ATOM   192  N  NH2 . ARG A 1 61  ? 168.702 193.346 106.561 1.00 93.06  ? 54  ARG B NH2 1 
ATOM   193  N  N   . THR A 1 62  ? 163.081 197.104 108.054 1.00 109.45 ? 55  THR B N   1 
ATOM   194  C  CA  . THR A 1 62  ? 161.943 196.269 107.697 1.00 101.49 ? 55  THR B CA  1 
ATOM   195  C  C   . THR A 1 62  ? 162.035 195.709 106.286 1.00 98.41  ? 55  THR B C   1 
ATOM   196  O  O   . THR A 1 62  ? 161.108 195.023 105.846 1.00 95.58  ? 55  THR B O   1 
ATOM   197  C  CB  . THR A 1 62  ? 160.644 197.062 107.841 1.00 104.04 ? 55  THR B CB  1 
ATOM   198  O  OG1 . THR A 1 62  ? 160.364 197.741 106.611 1.00 105.84 ? 55  THR B OG1 1 
ATOM   199  C  CG2 . THR A 1 62  ? 160.769 198.082 108.961 1.00 106.89 ? 55  THR B CG2 1 
ATOM   200  N  N   . ARG A 1 63  ? 163.113 195.988 105.571 1.00 99.06  ? 56  ARG B N   1 
ATOM   201  C  CA  . ARG A 1 63  ? 163.330 195.540 104.206 1.00 95.29  ? 56  ARG B CA  1 
ATOM   202  C  C   . ARG A 1 63  ? 164.701 194.894 104.116 1.00 92.70  ? 56  ARG B C   1 
ATOM   203  O  O   . ARG A 1 63  ? 165.585 195.182 104.929 1.00 97.11  ? 56  ARG B O   1 
ATOM   204  C  CB  . ARG A 1 63  ? 163.231 196.711 103.217 1.00 95.53  ? 56  ARG B CB  1 
ATOM   205  C  CG  . ARG A 1 63  ? 162.172 197.741 103.577 1.00 97.66  ? 56  ARG B CG  1 
ATOM   206  C  CD  . ARG A 1 63  ? 160.771 197.176 103.410 1.00 97.00  ? 56  ARG B CD  1 
ATOM   207  N  NE  . ARG A 1 63  ? 160.414 197.020 102.006 1.00 97.84  ? 56  ARG B NE  1 
ATOM   208  C  CZ  . ARG A 1 63  ? 159.991 198.007 101.230 1.00 99.00  ? 56  ARG B CZ  1 
ATOM   209  N  NH1 . ARG A 1 63  ? 159.842 199.236 101.696 1.00 101.59 ? 56  ARG B NH1 1 
ATOM   210  N  NH2 . ARG A 1 63  ? 159.709 197.756 99.955  1.00 94.45  ? 56  ARG B NH2 1 
ATOM   211  N  N   . PRO A 1 64  ? 164.911 194.002 103.148 1.00 88.71  ? 57  PRO B N   1 
ATOM   212  C  CA  . PRO A 1 64  ? 166.204 193.290 103.055 1.00 92.37  ? 57  PRO B CA  1 
ATOM   213  C  C   . PRO A 1 64  ? 167.300 194.131 102.411 1.00 100.02 ? 57  PRO B C   1 
ATOM   214  O  O   . PRO A 1 64  ? 167.849 193.810 101.354 1.00 101.45 ? 57  PRO B O   1 
ATOM   215  C  CB  . PRO A 1 64  ? 165.844 192.057 102.215 1.00 88.00  ? 57  PRO B CB  1 
ATOM   216  C  CG  . PRO A 1 64  ? 164.356 192.081 102.032 1.00 84.97  ? 57  PRO B CG  1 
ATOM   217  C  CD  . PRO A 1 64  ? 163.939 193.489 102.175 1.00 86.85  ? 57  PRO B CD  1 
ATOM   218  N  N   . SER A 1 65  ? 167.649 195.234 103.067 1.00 100.39 ? 58  SER B N   1 
ATOM   219  C  CA  . SER A 1 65  ? 168.652 196.164 102.570 1.00 99.73  ? 58  SER B CA  1 
ATOM   220  C  C   . SER A 1 65  ? 169.838 196.191 103.520 1.00 104.19 ? 58  SER B C   1 
ATOM   221  O  O   . SER A 1 65  ? 169.668 196.129 104.741 1.00 104.54 ? 58  SER B O   1 
ATOM   222  C  CB  . SER A 1 65  ? 168.079 197.573 102.423 1.00 97.30  ? 58  SER B CB  1 
ATOM   223  O  OG  . SER A 1 65  ? 168.455 198.387 103.519 1.00 103.55 ? 58  SER B OG  1 
ATOM   224  N  N   . SER A 1 66  ? 171.034 196.281 102.957 1.00 107.18 ? 59  SER B N   1 
ATOM   225  C  CA  . SER A 1 66  ? 172.238 196.351 103.771 1.00 110.58 ? 59  SER B CA  1 
ATOM   226  C  C   . SER A 1 66  ? 172.355 197.738 104.387 1.00 114.82 ? 59  SER B C   1 
ATOM   227  O  O   . SER A 1 66  ? 172.414 198.728 103.648 1.00 113.16 ? 59  SER B O   1 
ATOM   228  C  CB  . SER A 1 66  ? 173.469 196.044 102.933 1.00 105.96 ? 59  SER B CB  1 
ATOM   229  O  OG  . SER A 1 66  ? 173.384 196.677 101.670 1.00 104.27 ? 59  SER B OG  1 
ATOM   230  N  N   . PRO A 1 67  ? 172.388 197.859 105.713 1.00 115.08 ? 60  PRO B N   1 
ATOM   231  C  CA  . PRO A 1 67  ? 172.510 199.184 106.329 1.00 113.93 ? 60  PRO B CA  1 
ATOM   232  C  C   . PRO A 1 67  ? 173.830 199.842 105.965 1.00 117.13 ? 60  PRO B C   1 
ATOM   233  O  O   . PRO A 1 67  ? 174.845 199.177 105.752 1.00 115.06 ? 60  PRO B O   1 
ATOM   234  C  CB  . PRO A 1 67  ? 172.427 198.890 107.830 1.00 110.97 ? 60  PRO B CB  1 
ATOM   235  C  CG  . PRO A 1 67  ? 171.788 197.548 107.926 1.00 109.13 ? 60  PRO B CG  1 
ATOM   236  C  CD  . PRO A 1 67  ? 172.237 196.796 106.717 1.00 109.03 ? 60  PRO B CD  1 
ATOM   237  N  N   . VAL A 1 68  ? 173.804 201.169 105.890 1.00 120.79 ? 61  VAL B N   1 
ATOM   238  C  CA  . VAL A 1 68  ? 174.979 201.964 105.558 1.00 122.70 ? 61  VAL B CA  1 
ATOM   239  C  C   . VAL A 1 68  ? 175.449 202.691 106.810 1.00 122.70 ? 61  VAL B C   1 
ATOM   240  O  O   . VAL A 1 68  ? 174.643 203.268 107.551 1.00 120.43 ? 61  VAL B O   1 
ATOM   241  C  CB  . VAL A 1 68  ? 174.694 202.950 104.406 1.00 117.09 ? 61  VAL B CB  1 
ATOM   242  C  CG1 . VAL A 1 68  ? 174.378 202.186 103.133 1.00 110.01 ? 61  VAL B CG1 1 
ATOM   243  C  CG2 . VAL A 1 68  ? 173.542 203.875 104.756 1.00 119.34 ? 61  VAL B CG2 1 
ATOM   244  N  N   . CYS A 1 69  ? 176.752 202.638 107.058 1.00 121.75 ? 62  CYS B N   1 
ATOM   245  C  CA  . CYS A 1 69  ? 177.363 203.311 108.193 1.00 122.97 ? 62  CYS B CA  1 
ATOM   246  C  C   . CYS A 1 69  ? 178.023 204.592 107.707 1.00 123.15 ? 62  CYS B C   1 
ATOM   247  O  O   . CYS A 1 69  ? 178.828 204.564 106.770 1.00 122.02 ? 62  CYS B O   1 
ATOM   248  C  CB  . CYS A 1 69  ? 178.390 202.409 108.880 1.00 119.87 ? 62  CYS B CB  1 
ATOM   249  S  SG  . CYS A 1 69  ? 177.696 201.034 109.826 1.00 120.78 ? 62  CYS B SG  1 
ATOM   250  N  N   . THR A 1 70  ? 177.679 205.711 108.340 1.00 123.60 ? 63  THR B N   1 
ATOM   251  C  CA  . THR A 1 70  ? 178.173 207.015 107.922 1.00 122.37 ? 63  THR B CA  1 
ATOM   252  C  C   . THR A 1 70  ? 179.235 207.595 108.842 1.00 118.42 ? 63  THR B C   1 
ATOM   253  O  O   . THR A 1 70  ? 180.130 208.291 108.361 1.00 117.72 ? 63  THR B O   1 
ATOM   254  C  CB  . THR A 1 70  ? 177.012 208.010 107.812 1.00 122.32 ? 63  THR B CB  1 
ATOM   255  O  OG1 . THR A 1 70  ? 175.835 207.321 107.376 1.00 122.06 ? 63  THR B OG1 1 
ATOM   256  C  CG2 . THR A 1 70  ? 177.345 209.100 106.811 1.00 116.80 ? 63  THR B CG2 1 
ATOM   257  N  N   . ARG A 1 71  ? 179.160 207.334 110.144 1.00 116.10 ? 64  ARG B N   1 
ATOM   258  C  CA  . ARG A 1 71  ? 180.163 207.848 111.066 1.00 113.93 ? 64  ARG B CA  1 
ATOM   259  C  C   . ARG A 1 71  ? 181.522 207.230 110.764 1.00 114.87 ? 64  ARG B C   1 
ATOM   260  O  O   . ARG A 1 71  ? 181.622 206.049 110.427 1.00 115.22 ? 64  ARG B O   1 
ATOM   261  C  CB  . ARG A 1 71  ? 179.758 207.560 112.511 1.00 112.01 ? 64  ARG B CB  1 
ATOM   262  C  CG  . ARG A 1 71  ? 180.626 208.260 113.543 1.00 114.15 ? 64  ARG B CG  1 
ATOM   263  C  CD  . ARG A 1 71  ? 179.799 209.012 114.575 1.00 119.73 ? 64  ARG B CD  1 
ATOM   264  N  NE  . ARG A 1 71  ? 178.659 208.236 115.048 1.00 124.60 ? 64  ARG B NE  1 
ATOM   265  C  CZ  . ARG A 1 71  ? 177.393 208.606 114.916 1.00 126.68 ? 64  ARG B CZ  1 
ATOM   266  N  NH1 . ARG A 1 71  ? 177.063 209.743 114.325 1.00 128.63 ? 64  ARG B NH1 1 
ATOM   267  N  NH2 . ARG A 1 71  ? 176.434 207.818 115.391 1.00 122.56 ? 64  ARG B NH2 1 
ATOM   268  N  N   . PHE A 1 72  ? 182.571 208.037 110.890 1.00 114.04 ? 65  PHE B N   1 
ATOM   269  C  CA  . PHE A 1 72  ? 183.922 207.640 110.518 1.00 108.24 ? 65  PHE B CA  1 
ATOM   270  C  C   . PHE A 1 72  ? 184.708 207.204 111.747 1.00 102.91 ? 65  PHE B C   1 
ATOM   271  O  O   . PHE A 1 72  ? 184.569 207.787 112.825 1.00 103.17 ? 65  PHE B O   1 
ATOM   272  C  CB  . PHE A 1 72  ? 184.644 208.791 109.817 1.00 108.19 ? 65  PHE B CB  1 
ATOM   273  C  CG  . PHE A 1 72  ? 186.134 208.636 109.770 1.00 106.73 ? 65  PHE B CG  1 
ATOM   274  C  CD1 . PHE A 1 72  ? 186.724 207.790 108.853 1.00 107.65 ? 65  PHE B CD1 1 
ATOM   275  C  CD2 . PHE A 1 72  ? 186.945 209.343 110.638 1.00 106.71 ? 65  PHE B CD2 1 
ATOM   276  C  CE1 . PHE A 1 72  ? 188.095 207.649 108.806 1.00 104.53 ? 65  PHE B CE1 1 
ATOM   277  C  CE2 . PHE A 1 72  ? 188.315 209.204 110.596 1.00 105.29 ? 65  PHE B CE2 1 
ATOM   278  C  CZ  . PHE A 1 72  ? 188.890 208.357 109.679 1.00 103.00 ? 65  PHE B CZ  1 
ATOM   279  N  N   . SER A 1 73  ? 185.537 206.178 111.574 1.00 100.01 ? 66  SER B N   1 
ATOM   280  C  CA  . SER A 1 73  ? 186.383 205.649 112.635 1.00 97.58  ? 66  SER B CA  1 
ATOM   281  C  C   . SER A 1 73  ? 187.837 205.730 112.201 1.00 94.10  ? 66  SER B C   1 
ATOM   282  O  O   . SER A 1 73  ? 188.174 205.347 111.077 1.00 94.12  ? 66  SER B O   1 
ATOM   283  C  CB  . SER A 1 73  ? 186.010 204.205 112.967 1.00 93.97  ? 66  SER B CB  1 
ATOM   284  O  OG  . SER A 1 73  ? 186.867 203.676 113.961 1.00 91.77  ? 66  SER B OG  1 
ATOM   285  N  N   . SER A 1 74  ? 188.695 206.231 113.090 1.00 93.26  ? 67  SER B N   1 
ATOM   286  C  CA  . SER A 1 74  ? 190.107 206.383 112.757 1.00 93.45  ? 67  SER B CA  1 
ATOM   287  C  C   . SER A 1 74  ? 190.862 205.064 112.814 1.00 89.20  ? 67  SER B C   1 
ATOM   288  O  O   . SER A 1 74  ? 191.818 204.872 112.055 1.00 88.20  ? 67  SER B O   1 
ATOM   289  C  CB  . SER A 1 74  ? 190.766 207.390 113.697 1.00 97.52  ? 67  SER B CB  1 
ATOM   290  O  OG  . SER A 1 74  ? 191.331 206.735 114.817 1.00 94.99  ? 67  SER B OG  1 
ATOM   291  N  N   . ASN A 1 75  ? 190.469 204.156 113.710 1.00 85.51  ? 68  ASN B N   1 
ATOM   292  C  CA  . ASN A 1 75  ? 191.185 202.892 113.838 1.00 83.97  ? 68  ASN B CA  1 
ATOM   293  C  C   . ASN A 1 75  ? 191.087 202.067 112.562 1.00 82.55  ? 68  ASN B C   1 
ATOM   294  O  O   . ASN A 1 75  ? 192.089 201.515 112.090 1.00 83.23  ? 68  ASN B O   1 
ATOM   295  C  CB  . ASN A 1 75  ? 190.644 202.103 115.028 1.00 81.28  ? 68  ASN B CB  1 
ATOM   296  C  CG  . ASN A 1 75  ? 191.101 202.666 116.352 1.00 82.21  ? 68  ASN B CG  1 
ATOM   297  O  OD1 . ASN A 1 75  ? 192.162 203.278 116.444 1.00 82.29  ? 68  ASN B OD1 1 
ATOM   298  N  ND2 . ASN A 1 75  ? 190.302 202.459 117.390 1.00 85.55  ? 68  ASN B ND2 1 
ATOM   299  N  N   . GLY A 1 76  ? 189.888 201.969 111.991 1.00 79.91  ? 69  GLY B N   1 
ATOM   300  C  CA  . GLY A 1 76  ? 189.731 201.203 110.770 1.00 75.97  ? 69  GLY B CA  1 
ATOM   301  C  C   . GLY A 1 76  ? 190.529 201.781 109.621 1.00 76.32  ? 69  GLY B C   1 
ATOM   302  O  O   . GLY A 1 76  ? 191.168 201.048 108.865 1.00 76.93  ? 69  GLY B O   1 
ATOM   303  N  N   . LEU A 1 77  ? 190.507 203.105 109.476 1.00 78.26  ? 70  LEU B N   1 
ATOM   304  C  CA  . LEU A 1 77  ? 191.271 203.736 108.410 1.00 78.34  ? 70  LEU B CA  1 
ATOM   305  C  C   . LEU A 1 77  ? 192.765 203.529 108.608 1.00 78.22  ? 70  LEU B C   1 
ATOM   306  O  O   . LEU A 1 77  ? 193.499 203.299 107.642 1.00 80.45  ? 70  LEU B O   1 
ATOM   307  C  CB  . LEU A 1 77  ? 190.942 205.223 108.335 1.00 82.93  ? 70  LEU B CB  1 
ATOM   308  C  CG  . LEU A 1 77  ? 191.865 206.017 107.415 1.00 83.13  ? 70  LEU B CG  1 
ATOM   309  C  CD1 . LEU A 1 77  ? 191.705 205.555 105.982 1.00 81.24  ? 70  LEU B CD1 1 
ATOM   310  C  CD2 . LEU A 1 77  ? 191.578 207.492 107.537 1.00 92.25  ? 70  LEU B CD2 1 
ATOM   311  N  N   . LEU A 1 78  ? 193.237 203.612 109.851 1.00 76.28  ? 71  LEU B N   1 
ATOM   312  C  CA  . LEU A 1 78  ? 194.656 203.397 110.104 1.00 74.97  ? 71  LEU B CA  1 
ATOM   313  C  C   . LEU A 1 78  ? 195.065 201.968 109.779 1.00 77.48  ? 71  LEU B C   1 
ATOM   314  O  O   . LEU A 1 78  ? 196.128 201.739 109.194 1.00 78.10  ? 71  LEU B O   1 
ATOM   315  C  CB  . LEU A 1 78  ? 194.988 203.739 111.551 1.00 77.02  ? 71  LEU B CB  1 
ATOM   316  C  CG  . LEU A 1 78  ? 195.143 205.234 111.796 1.00 81.08  ? 71  LEU B CG  1 
ATOM   317  C  CD1 . LEU A 1 78  ? 195.061 205.538 113.276 1.00 87.72  ? 71  LEU B CD1 1 
ATOM   318  C  CD2 . LEU A 1 78  ? 196.453 205.715 111.211 1.00 84.86  ? 71  LEU B CD2 1 
ATOM   319  N  N   . TRP A 1 79  ? 194.233 200.992 110.142 1.00 76.89  ? 72  TRP B N   1 
ATOM   320  C  CA  . TRP A 1 79  ? 194.545 199.607 109.798 1.00 72.88  ? 72  TRP B CA  1 
ATOM   321  C  C   . TRP A 1 79  ? 194.518 199.388 108.290 1.00 71.23  ? 72  TRP B C   1 
ATOM   322  O  O   . TRP A 1 79  ? 195.349 198.648 107.748 1.00 69.71  ? 72  TRP B O   1 
ATOM   323  C  CB  . TRP A 1 79  ? 193.576 198.660 110.498 1.00 72.92  ? 72  TRP B CB  1 
ATOM   324  C  CG  . TRP A 1 79  ? 193.661 198.726 111.978 1.00 71.72  ? 72  TRP B CG  1 
ATOM   325  C  CD1 . TRP A 1 79  ? 194.742 199.089 112.711 1.00 72.53  ? 72  TRP B CD1 1 
ATOM   326  C  CD2 . TRP A 1 79  ? 192.624 198.421 112.913 1.00 73.35  ? 72  TRP B CD2 1 
ATOM   327  N  NE1 . TRP A 1 79  ? 194.447 199.032 114.047 1.00 75.11  ? 72  TRP B NE1 1 
ATOM   328  C  CE2 . TRP A 1 79  ? 193.151 198.622 114.197 1.00 72.78  ? 72  TRP B CE2 1 
ATOM   329  C  CE3 . TRP A 1 79  ? 191.300 198.000 112.788 1.00 73.96  ? 72  TRP B CE3 1 
ATOM   330  C  CZ2 . TRP A 1 79  ? 192.405 198.416 115.348 1.00 75.27  ? 72  TRP B CZ2 1 
ATOM   331  C  CZ3 . TRP A 1 79  ? 190.561 197.796 113.932 1.00 71.82  ? 72  TRP B CZ3 1 
ATOM   332  C  CH2 . TRP A 1 79  ? 191.114 198.004 115.194 1.00 73.88  ? 72  TRP B CH2 1 
ATOM   333  N  N   . ALA A 1 80  ? 193.562 200.007 107.596 1.00 72.40  ? 73  ALA B N   1 
ATOM   334  C  CA  . ALA A 1 80  ? 193.517 199.889 106.143 1.00 69.80  ? 73  ALA B CA  1 
ATOM   335  C  C   . ALA A 1 80  ? 194.764 200.481 105.508 1.00 71.76  ? 73  ALA B C   1 
ATOM   336  O  O   . ALA A 1 80  ? 195.335 199.897 104.580 1.00 77.35  ? 73  ALA B O   1 
ATOM   337  C  CB  . ALA A 1 80  ? 192.264 200.570 105.599 1.00 71.25  ? 73  ALA B CB  1 
ATOM   338  N  N   . LEU A 1 81  ? 195.204 201.640 105.996 1.00 71.79  ? 74  LEU B N   1 
ATOM   339  C  CA  . LEU A 1 81  ? 196.436 202.234 105.491 1.00 74.76  ? 74  LEU B CA  1 
ATOM   340  C  C   . LEU A 1 81  ? 197.634 201.351 105.804 1.00 77.65  ? 74  LEU B C   1 
ATOM   341  O  O   . LEU A 1 81  ? 198.574 201.267 105.009 1.00 82.25  ? 74  LEU B O   1 
ATOM   342  C  CB  . LEU A 1 81  ? 196.630 203.628 106.082 1.00 78.79  ? 74  LEU B CB  1 
ATOM   343  C  CG  . LEU A 1 81  ? 196.038 204.791 105.291 1.00 78.43  ? 74  LEU B CG  1 
ATOM   344  C  CD1 . LEU A 1 81  ? 195.756 205.969 106.204 1.00 76.95  ? 74  LEU B CD1 1 
ATOM   345  C  CD2 . LEU A 1 81  ? 196.982 205.190 104.181 1.00 84.01  ? 74  LEU B CD2 1 
ATOM   346  N  N   . ALA A 1 82  ? 197.620 200.685 106.960 1.00 73.97  ? 75  ALA B N   1 
ATOM   347  C  CA  . ALA A 1 82  ? 198.701 199.763 107.292 1.00 72.36  ? 75  ALA B CA  1 
ATOM   348  C  C   . ALA A 1 82  ? 198.764 198.605 106.308 1.00 73.70  ? 75  ALA B C   1 
ATOM   349  O  O   . ALA A 1 82  ? 199.844 198.250 105.822 1.00 72.98  ? 75  ALA B O   1 
ATOM   350  C  CB  . ALA A 1 82  ? 198.524 199.240 108.715 1.00 73.04  ? 75  ALA B CB  1 
ATOM   351  N  N   . MET A 1 83  ? 197.616 198.003 105.998 1.00 73.70  ? 76  MET B N   1 
ATOM   352  C  CA  . MET A 1 83  ? 197.618 196.899 105.043 1.00 70.69  ? 76  MET B CA  1 
ATOM   353  C  C   . MET A 1 83  ? 198.026 197.380 103.659 1.00 70.44  ? 76  MET B C   1 
ATOM   354  O  O   . MET A 1 83  ? 198.747 196.681 102.938 1.00 72.88  ? 76  MET B O   1 
ATOM   355  C  CB  . MET A 1 83  ? 196.252 196.224 104.986 1.00 69.23  ? 76  MET B CB  1 
ATOM   356  C  CG  . MET A 1 83  ? 196.020 195.472 103.695 1.00 65.11  ? 76  MET B CG  1 
ATOM   357  S  SD  . MET A 1 83  ? 194.823 194.149 103.870 1.00 71.04  ? 76  MET B SD  1 
ATOM   358  C  CE  . MET A 1 83  ? 194.351 193.913 102.168 1.00 60.88  ? 76  MET B CE  1 
ATOM   359  N  N   . LYS A 1 84  ? 197.571 198.571 103.269 1.00 72.18  ? 77  LYS B N   1 
ATOM   360  C  CA  . LYS A 1 84  ? 197.966 199.129 101.981 1.00 74.09  ? 77  LYS B CA  1 
ATOM   361  C  C   . LYS A 1 84  ? 199.471 199.344 101.916 1.00 76.80  ? 77  LYS B C   1 
ATOM   362  O  O   . LYS A 1 84  ? 200.108 199.037 100.901 1.00 81.76  ? 77  LYS B O   1 
ATOM   363  C  CB  . LYS A 1 84  ? 197.225 200.439 101.738 1.00 73.68  ? 77  LYS B CB  1 
ATOM   364  C  CG  . LYS A 1 84  ? 197.267 200.908 100.307 1.00 79.61  ? 77  LYS B CG  1 
ATOM   365  C  CD  . LYS A 1 84  ? 196.149 201.884 100.028 1.00 86.48  ? 77  LYS B CD  1 
ATOM   366  C  CE  . LYS A 1 84  ? 196.688 203.290 99.890  1.00 94.19  ? 77  LYS B CE  1 
ATOM   367  N  NZ  . LYS A 1 84  ? 197.957 203.298 99.121  1.00 95.38  ? 77  LYS B NZ  1 
ATOM   368  N  N   . MET A 1 85  ? 200.058 199.865 102.993 1.00 75.91  ? 78  MET B N   1 
ATOM   369  C  CA  . MET A 1 85  ? 201.502 200.042 103.040 1.00 80.01  ? 78  MET B CA  1 
ATOM   370  C  C   . MET A 1 85  ? 202.219 198.705 102.948 1.00 80.01  ? 78  MET B C   1 
ATOM   371  O  O   . MET A 1 85  ? 203.230 198.581 102.247 1.00 82.49  ? 78  MET B O   1 
ATOM   372  C  CB  . MET A 1 85  ? 201.895 200.769 104.323 1.00 81.87  ? 78  MET B CB  1 
ATOM   373  C  CG  . MET A 1 85  ? 203.377 200.748 104.608 1.00 84.23  ? 78  MET B CG  1 
ATOM   374  S  SD  . MET A 1 85  ? 203.735 200.845 106.366 1.00 95.34  ? 78  MET B SD  1 
ATOM   375  C  CE  . MET A 1 85  ? 205.453 200.353 106.370 1.00 92.76  ? 78  MET B CE  1 
ATOM   376  N  N   . ALA A 1 86  ? 201.713 197.692 103.652 1.00 75.20  ? 79  ALA B N   1 
ATOM   377  C  CA  . ALA A 1 86  ? 202.339 196.377 103.599 1.00 76.32  ? 79  ALA B CA  1 
ATOM   378  C  C   . ALA A 1 86  ? 202.314 195.818 102.184 1.00 75.76  ? 79  ALA B C   1 
ATOM   379  O  O   . ALA A 1 86  ? 203.326 195.315 101.683 1.00 77.55  ? 79  ALA B O   1 
ATOM   380  C  CB  . ALA A 1 86  ? 201.642 195.423 104.565 1.00 70.27  ? 79  ALA B CB  1 
ATOM   381  N  N   . VAL A 1 87  ? 201.167 195.915 101.515 1.00 75.04  ? 80  VAL B N   1 
ATOM   382  C  CA  . VAL A 1 87  ? 201.056 195.378 100.164 1.00 71.15  ? 80  VAL B CA  1 
ATOM   383  C  C   . VAL A 1 87  ? 201.967 196.134 99.209  1.00 72.45  ? 80  VAL B C   1 
ATOM   384  O  O   . VAL A 1 87  ? 202.644 195.532 98.367  1.00 78.15  ? 80  VAL B O   1 
ATOM   385  C  CB  . VAL A 1 87  ? 199.594 195.409 99.696  1.00 70.74  ? 80  VAL B CB  1 
ATOM   386  C  CG1 . VAL A 1 87  ? 199.526 195.296 98.194  1.00 73.45  ? 80  VAL B CG1 1 
ATOM   387  C  CG2 . VAL A 1 87  ? 198.822 194.283 100.341 1.00 71.56  ? 80  VAL B CG2 1 
ATOM   388  N  N   . GLU A 1 88  ? 202.001 197.461 99.316  1.00 72.08  ? 81  GLU B N   1 
ATOM   389  C  CA  . GLU A 1 88  ? 202.839 198.238 98.412  1.00 77.05  ? 81  GLU B CA  1 
ATOM   390  C  C   . GLU A 1 88  ? 204.316 197.947 98.633  1.00 78.17  ? 81  GLU B C   1 
ATOM   391  O  O   . GLU A 1 88  ? 205.084 197.855 97.670  1.00 84.54  ? 81  GLU B O   1 
ATOM   392  C  CB  . GLU A 1 88  ? 202.543 199.725 98.572  1.00 86.73  ? 81  GLU B CB  1 
ATOM   393  C  CG  . GLU A 1 88  ? 201.217 200.132 97.967  1.00 89.16  ? 81  GLU B CG  1 
ATOM   394  C  CD  . GLU A 1 88  ? 200.882 201.582 98.222  1.00 95.47  ? 81  GLU B CD  1 
ATOM   395  O  OE1 . GLU A 1 88  ? 201.530 202.198 99.093  1.00 95.50  ? 81  GLU B OE1 1 
ATOM   396  O  OE2 . GLU A 1 88  ? 199.975 202.107 97.543  1.00 94.38  ? 81  GLU B OE2 1 
ATOM   397  N  N   . GLU A 1 89  ? 204.738 197.789 99.888  1.00 74.40  ? 82  GLU B N   1 
ATOM   398  C  CA  . GLU A 1 89  ? 206.146 197.501 100.130 1.00 80.46  ? 82  GLU B CA  1 
ATOM   399  C  C   . GLU A 1 89  ? 206.495 196.064 99.759  1.00 78.75  ? 82  GLU B C   1 
ATOM   400  O  O   . GLU A 1 89  ? 207.657 195.769 99.459  1.00 80.76  ? 82  GLU B O   1 
ATOM   401  C  CB  . GLU A 1 89  ? 206.505 197.794 101.585 1.00 76.53  ? 82  GLU B CB  1 
ATOM   402  C  CG  . GLU A 1 89  ? 206.537 196.587 102.483 1.00 77.51  ? 82  GLU B CG  1 
ATOM   403  C  CD  . GLU A 1 89  ? 207.182 196.888 103.812 1.00 83.32  ? 82  GLU B CD  1 
ATOM   404  O  OE1 . GLU A 1 89  ? 206.777 197.875 104.459 1.00 84.38  ? 82  GLU B OE1 1 
ATOM   405  O  OE2 . GLU A 1 89  ? 208.103 196.146 104.206 1.00 85.85  ? 82  GLU B OE2 1 
ATOM   406  N  N   . ILE A 1 90  ? 205.513 195.161 99.772  1.00 76.06  ? 83  ILE B N   1 
ATOM   407  C  CA  . ILE A 1 90  ? 205.750 193.807 99.281  1.00 71.31  ? 83  ILE B CA  1 
ATOM   408  C  C   . ILE A 1 90  ? 205.923 193.820 97.770  1.00 75.59  ? 83  ILE B C   1 
ATOM   409  O  O   . ILE A 1 90  ? 206.794 193.134 97.224  1.00 75.36  ? 83  ILE B O   1 
ATOM   410  C  CB  . ILE A 1 90  ? 204.605 192.880 99.719  1.00 64.29  ? 83  ILE B CB  1 
ATOM   411  C  CG1 . ILE A 1 90  ? 204.925 192.271 101.075 1.00 65.37  ? 83  ILE B CG1 1 
ATOM   412  C  CG2 . ILE A 1 90  ? 204.381 191.780 98.710  1.00 61.76  ? 83  ILE B CG2 1 
ATOM   413  C  CD1 . ILE A 1 90  ? 203.738 191.651 101.730 1.00 68.40  ? 83  ILE B CD1 1 
ATOM   414  N  N   . ASN A 1 91  ? 205.102 194.606 97.072  1.00 78.24  ? 84  ASN B N   1 
ATOM   415  C  CA  . ASN A 1 91  ? 205.286 194.772 95.635  1.00 76.85  ? 84  ASN B CA  1 
ATOM   416  C  C   . ASN A 1 91  ? 206.631 195.414 95.328  1.00 80.98  ? 84  ASN B C   1 
ATOM   417  O  O   . ASN A 1 91  ? 207.268 195.090 94.320  1.00 82.14  ? 84  ASN B O   1 
ATOM   418  C  CB  . ASN A 1 91  ? 204.150 195.606 95.052  1.00 73.15  ? 84  ASN B CB  1 
ATOM   419  C  CG  . ASN A 1 91  ? 202.868 194.825 94.930  1.00 75.50  ? 84  ASN B CG  1 
ATOM   420  O  OD1 . ASN A 1 91  ? 202.885 193.601 94.823  1.00 76.66  ? 84  ASN B OD1 1 
ATOM   421  N  ND2 . ASN A 1 91  ? 201.744 195.527 94.950  1.00 77.51  ? 84  ASN B ND2 1 
ATOM   422  N  N   . ASN A 1 92  ? 207.077 196.335 96.184  1.00 83.39  ? 85  ASN B N   1 
ATOM   423  C  CA  . ASN A 1 92  ? 208.399 196.926 96.008  1.00 84.51  ? 85  ASN B CA  1 
ATOM   424  C  C   . ASN A 1 92  ? 209.494 195.877 96.136  1.00 84.27  ? 85  ASN B C   1 
ATOM   425  O  O   . ASN A 1 92  ? 210.500 195.928 95.420  1.00 82.80  ? 85  ASN B O   1 
ATOM   426  C  CB  . ASN A 1 92  ? 208.616 198.045 97.024  1.00 91.08  ? 85  ASN B CB  1 
ATOM   427  C  CG  . ASN A 1 92  ? 208.434 199.417 96.424  1.00 99.98  ? 85  ASN B CG  1 
ATOM   428  O  OD1 . ASN A 1 92  ? 208.064 199.552 95.259  1.00 101.69 ? 85  ASN B OD1 1 
ATOM   429  N  ND2 . ASN A 1 92  ? 208.701 200.449 97.214  1.00 107.86 ? 85  ASN B ND2 1 
ATOM   430  N  N   . LYS A 1 93  ? 209.319 194.923 97.048  1.00 83.64  ? 86  LYS B N   1 
ATOM   431  C  CA  . LYS A 1 93  ? 210.330 193.898 97.261  1.00 82.77  ? 86  LYS B CA  1 
ATOM   432  C  C   . LYS A 1 93  ? 210.514 193.059 96.005  1.00 89.21  ? 86  LYS B C   1 
ATOM   433  O  O   . LYS A 1 93  ? 209.563 192.798 95.266  1.00 90.90  ? 86  LYS B O   1 
ATOM   434  C  CB  . LYS A 1 93  ? 209.938 193.007 98.437  1.00 80.02  ? 86  LYS B CB  1 
ATOM   435  C  CG  . LYS A 1 93  ? 210.446 193.498 99.777  1.00 78.44  ? 86  LYS B CG  1 
ATOM   436  C  CD  . LYS A 1 93  ? 209.978 192.605 100.910 1.00 75.80  ? 86  LYS B CD  1 
ATOM   437  C  CE  . LYS A 1 93  ? 210.772 191.316 100.959 1.00 76.04  ? 86  LYS B CE  1 
ATOM   438  N  NZ  . LYS A 1 93  ? 212.210 191.564 101.237 1.00 80.35  ? 86  LYS B NZ  1 
ATOM   439  N  N   . SER A 1 94  ? 211.755 192.643 95.761  1.00 95.18  ? 87  SER B N   1 
ATOM   440  C  CA  . SER A 1 94  ? 212.092 191.838 94.595  1.00 96.21  ? 87  SER B CA  1 
ATOM   441  C  C   . SER A 1 94  ? 212.165 190.350 94.899  1.00 93.54  ? 87  SER B C   1 
ATOM   442  O  O   . SER A 1 94  ? 211.637 189.541 94.132  1.00 93.11  ? 87  SER B O   1 
ATOM   443  C  CB  . SER A 1 94  ? 213.426 192.300 94.003  1.00 94.78  ? 87  SER B CB  1 
ATOM   444  O  OG  . SER A 1 94  ? 213.223 193.235 92.958  1.00 93.97  ? 87  SER B OG  1 
ATOM   445  N  N   . ASP A 1 95  ? 212.802 189.966 96.002  1.00 91.61  ? 88  ASP B N   1 
ATOM   446  C  CA  . ASP A 1 95  ? 212.955 188.554 96.316  1.00 96.99  ? 88  ASP B CA  1 
ATOM   447  C  C   . ASP A 1 95  ? 211.679 187.919 96.849  1.00 100.17 ? 88  ASP B C   1 
ATOM   448  O  O   . ASP A 1 95  ? 211.632 186.693 96.988  1.00 106.30 ? 88  ASP B O   1 
ATOM   449  C  CB  . ASP A 1 95  ? 214.087 188.359 97.323  1.00 97.73  ? 88  ASP B CB  1 
ATOM   450  C  CG  . ASP A 1 95  ? 214.068 189.391 98.423  1.00 99.69  ? 88  ASP B CG  1 
ATOM   451  O  OD1 . ASP A 1 95  ? 212.986 189.624 98.999  1.00 97.23  ? 88  ASP B OD1 1 
ATOM   452  O  OD2 . ASP A 1 95  ? 215.135 189.972 98.711  1.00 106.16 ? 88  ASP B OD2 1 
ATOM   453  N  N   . LEU A 1 96  ? 210.654 188.710 97.155  1.00 94.19  ? 89  LEU B N   1 
ATOM   454  C  CA  . LEU A 1 96  ? 209.371 188.197 97.618  1.00 90.55  ? 89  LEU B CA  1 
ATOM   455  C  C   . LEU A 1 96  ? 208.309 188.543 96.585  1.00 91.99  ? 89  LEU B C   1 
ATOM   456  O  O   . LEU A 1 96  ? 208.133 189.717 96.243  1.00 89.47  ? 89  LEU B O   1 
ATOM   457  C  CB  . LEU A 1 96  ? 209.006 188.773 98.986  1.00 84.23  ? 89  LEU B CB  1 
ATOM   458  C  CG  . LEU A 1 96  ? 207.612 188.432 99.498  1.00 74.51  ? 89  LEU B CG  1 
ATOM   459  C  CD1 . LEU A 1 96  ? 207.447 186.938 99.561  1.00 76.05  ? 89  LEU B CD1 1 
ATOM   460  C  CD2 . LEU A 1 96  ? 207.395 189.041 100.862 1.00 70.82  ? 89  LEU B CD2 1 
ATOM   461  N  N   . LEU A 1 97  ? 207.602 187.525 96.106  1.00 93.22  ? 90  LEU B N   1 
ATOM   462  C  CA  . LEU A 1 97  ? 206.627 187.666 95.031  1.00 95.46  ? 90  LEU B CA  1 
ATOM   463  C  C   . LEU A 1 97  ? 207.214 188.405 93.826  1.00 100.27 ? 90  LEU B C   1 
ATOM   464  O  O   . LEU A 1 97  ? 206.774 189.510 93.494  1.00 96.05  ? 90  LEU B O   1 
ATOM   465  C  CB  . LEU A 1 97  ? 205.369 188.365 95.529  1.00 87.24  ? 90  LEU B CB  1 
ATOM   466  C  CG  . LEU A 1 97  ? 204.391 187.484 96.300  1.00 76.17  ? 90  LEU B CG  1 
ATOM   467  C  CD1 . LEU A 1 97  ? 203.011 188.103 96.293  1.00 70.49  ? 90  LEU B CD1 1 
ATOM   468  C  CD2 . LEU A 1 97  ? 204.358 186.094 95.706  1.00 82.22  ? 90  LEU B CD2 1 
ATOM   469  N  N   . PRO A 1 98  ? 208.206 187.823 93.153  1.00 101.71 ? 91  PRO B N   1 
ATOM   470  C  CA  . PRO A 1 98  ? 208.816 188.506 92.009  1.00 99.67  ? 91  PRO B CA  1 
ATOM   471  C  C   . PRO A 1 98  ? 207.958 188.363 90.765  1.00 99.99  ? 91  PRO B C   1 
ATOM   472  O  O   . PRO A 1 98  ? 207.471 187.277 90.441  1.00 104.40 ? 91  PRO B O   1 
ATOM   473  C  CB  . PRO A 1 98  ? 210.160 187.784 91.837  1.00 98.83  ? 91  PRO B CB  1 
ATOM   474  C  CG  . PRO A 1 98  ? 210.202 186.712 92.907  1.00 101.43 ? 91  PRO B CG  1 
ATOM   475  C  CD  . PRO A 1 98  ? 208.807 186.502 93.371  1.00 100.18 ? 91  PRO B CD  1 
ATOM   476  N  N   . GLY A 1 99  ? 207.769 189.478 90.068  1.00 97.23  ? 92  GLY B N   1 
ATOM   477  C  CA  . GLY A 1 99  ? 207.030 189.455 88.826  1.00 92.77  ? 92  GLY B CA  1 
ATOM   478  C  C   . GLY A 1 99  ? 205.536 189.301 88.969  1.00 88.87  ? 92  GLY B C   1 
ATOM   479  O  O   . GLY A 1 99  ? 204.854 189.082 87.962  1.00 85.29  ? 92  GLY B O   1 
ATOM   480  N  N   . LEU A 1 100 ? 205.002 189.395 90.183  1.00 90.82  ? 93  LEU B N   1 
ATOM   481  C  CA  . LEU A 1 100 ? 203.566 189.346 90.408  1.00 91.64  ? 93  LEU B CA  1 
ATOM   482  C  C   . LEU A 1 100 ? 203.142 190.563 91.213  1.00 89.24  ? 93  LEU B C   1 
ATOM   483  O  O   . LEU A 1 100 ? 203.829 190.965 92.157  1.00 87.96  ? 93  LEU B O   1 
ATOM   484  C  CB  . LEU A 1 100 ? 203.148 188.071 91.144  1.00 91.95  ? 93  LEU B CB  1 
ATOM   485  C  CG  . LEU A 1 100 ? 203.409 186.745 90.435  1.00 93.72  ? 93  LEU B CG  1 
ATOM   486  C  CD1 . LEU A 1 100 ? 203.267 185.600 91.416  1.00 93.61  ? 93  LEU B CD1 1 
ATOM   487  C  CD2 . LEU A 1 100 ? 202.469 186.568 89.261  1.00 93.54  ? 93  LEU B CD2 1 
ATOM   488  N  N   . ARG A 1 101 ? 202.010 191.144 90.837  1.00 83.22  ? 94  ARG B N   1 
ATOM   489  C  CA  . ARG A 1 101 ? 201.446 192.283 91.543  1.00 76.18  ? 94  ARG B CA  1 
ATOM   490  C  C   . ARG A 1 101 ? 200.400 191.784 92.528  1.00 74.45  ? 94  ARG B C   1 
ATOM   491  O  O   . ARG A 1 101 ? 199.556 190.957 92.175  1.00 77.71  ? 94  ARG B O   1 
ATOM   492  C  CB  . ARG A 1 101 ? 200.822 193.278 90.566  1.00 78.03  ? 94  ARG B CB  1 
ATOM   493  C  CG  . ARG A 1 101 ? 201.804 194.281 89.996  1.00 79.13  ? 94  ARG B CG  1 
ATOM   494  C  CD  . ARG A 1 101 ? 201.269 195.700 90.097  1.00 91.62  ? 94  ARG B CD  1 
ATOM   495  N  NE  . ARG A 1 101 ? 202.288 196.688 89.763  1.00 102.56 ? 94  ARG B NE  1 
ATOM   496  C  CZ  . ARG A 1 101 ? 203.216 197.124 90.603  1.00 97.01  ? 94  ARG B CZ  1 
ATOM   497  N  NH1 . ARG A 1 101 ? 203.283 196.685 91.849  1.00 90.96  ? 94  ARG B NH1 1 
ATOM   498  N  NH2 . ARG A 1 101 ? 204.099 198.025 90.183  1.00 90.96  ? 94  ARG B NH2 1 
ATOM   499  N  N   . LEU A 1 102 ? 200.464 192.278 93.757  1.00 72.45  ? 95  LEU B N   1 
ATOM   500  C  CA  . LEU A 1 102 ? 199.518 191.906 94.798  1.00 69.13  ? 95  LEU B CA  1 
ATOM   501  C  C   . LEU A 1 102 ? 198.481 193.011 94.939  1.00 72.03  ? 95  LEU B C   1 
ATOM   502  O  O   . LEU A 1 102 ? 198.833 194.171 95.173  1.00 78.99  ? 95  LEU B O   1 
ATOM   503  C  CB  . LEU A 1 102 ? 200.235 191.671 96.124  1.00 65.21  ? 95  LEU B CB  1 
ATOM   504  C  CG  . LEU A 1 102 ? 199.553 190.713 97.095  1.00 63.05  ? 95  LEU B CG  1 
ATOM   505  C  CD1 . LEU A 1 102 ? 199.553 189.310 96.530  1.00 65.56  ? 95  LEU B CD1 1 
ATOM   506  C  CD2 . LEU A 1 102 ? 200.241 190.748 98.440  1.00 62.37  ? 95  LEU B CD2 1 
ATOM   507  N  N   . GLY A 1 103 ? 197.207 192.652 94.792  1.00 69.44  ? 96  GLY B N   1 
ATOM   508  C  CA  . GLY A 1 103 ? 196.122 193.598 94.912  1.00 72.20  ? 96  GLY B CA  1 
ATOM   509  C  C   . GLY A 1 103 ? 195.449 193.526 96.274  1.00 72.24  ? 96  GLY B C   1 
ATOM   510  O  O   . GLY A 1 103 ? 195.884 192.828 97.184  1.00 71.99  ? 96  GLY B O   1 
ATOM   511  N  N   . TYR A 1 104 ? 194.363 194.282 96.398  1.00 72.87  ? 97  TYR B N   1 
ATOM   512  C  CA  . TYR A 1 104 ? 193.572 194.274 97.620  1.00 68.52  ? 97  TYR B CA  1 
ATOM   513  C  C   . TYR A 1 104 ? 192.238 194.947 97.349  1.00 68.33  ? 97  TYR B C   1 
ATOM   514  O  O   . TYR A 1 104 ? 192.140 195.832 96.497  1.00 73.03  ? 97  TYR B O   1 
ATOM   515  C  CB  . TYR A 1 104 ? 194.301 194.976 98.770  1.00 68.06  ? 97  TYR B CB  1 
ATOM   516  C  CG  . TYR A 1 104 ? 194.925 196.294 98.397  1.00 74.32  ? 97  TYR B CG  1 
ATOM   517  C  CD1 . TYR A 1 104 ? 196.202 196.350 97.867  1.00 72.77  ? 97  TYR B CD1 1 
ATOM   518  C  CD2 . TYR A 1 104 ? 194.246 197.484 98.586  1.00 77.14  ? 97  TYR B CD2 1 
ATOM   519  C  CE1 . TYR A 1 104 ? 196.780 197.547 97.524  1.00 76.66  ? 97  TYR B CE1 1 
ATOM   520  C  CE2 . TYR A 1 104 ? 194.817 198.688 98.246  1.00 81.01  ? 97  TYR B CE2 1 
ATOM   521  C  CZ  . TYR A 1 104 ? 196.084 198.714 97.716  1.00 82.62  ? 97  TYR B CZ  1 
ATOM   522  O  OH  . TYR A 1 104 ? 196.659 199.914 97.373  1.00 87.71  ? 97  TYR B OH  1 
ATOM   523  N  N   . ASP A 1 105 ? 191.215 194.511 98.081  1.00 65.73  ? 98  ASP B N   1 
ATOM   524  C  CA  . ASP A 1 105 ? 189.875 195.096 98.030  1.00 72.63  ? 98  ASP B CA  1 
ATOM   525  C  C   . ASP A 1 105 ? 189.455 195.398 99.465  1.00 71.09  ? 98  ASP B C   1 
ATOM   526  O  O   . ASP A 1 105 ? 188.806 194.575 100.112 1.00 70.74  ? 98  ASP B O   1 
ATOM   527  C  CB  . ASP A 1 105 ? 188.887 194.161 97.348  1.00 76.95  ? 98  ASP B CB  1 
ATOM   528  C  CG  . ASP A 1 105 ? 188.895 194.302 95.845  1.00 84.42  ? 98  ASP B CG  1 
ATOM   529  O  OD1 . ASP A 1 105 ? 189.743 195.052 95.326  1.00 86.37  ? 98  ASP B OD1 1 
ATOM   530  O  OD2 . ASP A 1 105 ? 188.046 193.671 95.181  1.00 86.54  ? 98  ASP B OD2 1 
ATOM   531  N  N   . LEU A 1 106 ? 189.825 196.575 99.961  1.00 72.12  ? 99  LEU B N   1 
ATOM   532  C  CA  . LEU A 1 106 ? 189.458 196.960 101.316 1.00 66.67  ? 99  LEU B CA  1 
ATOM   533  C  C   . LEU A 1 106 ? 187.970 197.268 101.385 1.00 67.58  ? 99  LEU B C   1 
ATOM   534  O  O   . LEU A 1 106 ? 187.438 198.006 100.553 1.00 76.42  ? 99  LEU B O   1 
ATOM   535  C  CB  . LEU A 1 106 ? 190.270 198.171 101.758 1.00 69.10  ? 99  LEU B CB  1 
ATOM   536  C  CG  . LEU A 1 106 ? 191.770 198.049 101.517 1.00 71.32  ? 99  LEU B CG  1 
ATOM   537  C  CD1 . LEU A 1 106 ? 192.499 199.238 102.097 1.00 77.13  ? 99  LEU B CD1 1 
ATOM   538  C  CD2 . LEU A 1 106 ? 192.279 196.775 102.134 1.00 68.54  ? 99  LEU B CD2 1 
ATOM   539  N  N   . PHE A 1 107 ? 187.295 196.702 102.378 1.00 63.17  ? 100 PHE B N   1 
ATOM   540  C  CA  . PHE A 1 107 ? 185.855 196.836 102.517 1.00 62.90  ? 100 PHE B CA  1 
ATOM   541  C  C   . PHE A 1 107 ? 185.512 197.360 103.900 1.00 65.48  ? 100 PHE B C   1 
ATOM   542  O  O   . PHE A 1 107 ? 186.076 196.914 104.900 1.00 68.12  ? 100 PHE B O   1 
ATOM   543  C  CB  . PHE A 1 107 ? 185.154 195.500 102.289 1.00 67.09  ? 100 PHE B CB  1 
ATOM   544  C  CG  . PHE A 1 107 ? 184.867 195.208 100.851 1.00 70.68  ? 100 PHE B CG  1 
ATOM   545  C  CD1 . PHE A 1 107 ? 183.802 195.808 100.212 1.00 71.19  ? 100 PHE B CD1 1 
ATOM   546  C  CD2 . PHE A 1 107 ? 185.658 194.330 100.140 1.00 69.55  ? 100 PHE B CD2 1 
ATOM   547  C  CE1 . PHE A 1 107 ? 183.537 195.539 98.890  1.00 74.34  ? 100 PHE B CE1 1 
ATOM   548  C  CE2 . PHE A 1 107 ? 185.397 194.058 98.820  1.00 70.24  ? 100 PHE B CE2 1 
ATOM   549  C  CZ  . PHE A 1 107 ? 184.335 194.663 98.194  1.00 78.14  ? 100 PHE B CZ  1 
ATOM   550  N  N   . ASP A 1 108 ? 184.576 198.298 103.952 1.00 73.20  ? 101 ASP B N   1 
ATOM   551  C  CA  . ASP A 1 108 ? 184.103 198.828 105.223 1.00 79.43  ? 101 ASP B CA  1 
ATOM   552  C  C   . ASP A 1 108 ? 183.073 197.870 105.799 1.00 78.39  ? 101 ASP B C   1 
ATOM   553  O  O   . ASP A 1 108 ? 182.009 197.662 105.210 1.00 80.80  ? 101 ASP B O   1 
ATOM   554  C  CB  . ASP A 1 108 ? 183.498 200.215 105.048 1.00 86.79  ? 101 ASP B CB  1 
ATOM   555  C  CG  . ASP A 1 108 ? 182.515 200.561 106.152 1.00 92.15  ? 101 ASP B CG  1 
ATOM   556  O  OD1 . ASP A 1 108 ? 182.879 200.434 107.339 1.00 87.87  ? 101 ASP B OD1 1 
ATOM   557  O  OD2 . ASP A 1 108 ? 181.371 200.947 105.833 1.00 99.48  ? 101 ASP B OD2 1 
ATOM   558  N  N   . THR A 1 109 ? 183.389 197.280 106.944 1.00 77.39  ? 102 THR B N   1 
ATOM   559  C  CA  . THR A 1 109 ? 182.424 196.525 107.725 1.00 79.15  ? 102 THR B CA  1 
ATOM   560  C  C   . THR A 1 109 ? 182.267 197.227 109.062 1.00 85.12  ? 102 THR B C   1 
ATOM   561  O  O   . THR A 1 109 ? 183.257 197.480 109.754 1.00 87.08  ? 102 THR B O   1 
ATOM   562  C  CB  . THR A 1 109 ? 182.869 195.076 107.922 1.00 72.62  ? 102 THR B CB  1 
ATOM   563  O  OG1 . THR A 1 109 ? 183.637 194.960 109.124 1.00 67.57  ? 102 THR B OG1 1 
ATOM   564  C  CG2 . THR A 1 109 ? 183.712 194.626 106.759 1.00 73.32  ? 102 THR B CG2 1 
ATOM   565  N  N   . CYS A 1 110 ? 181.033 197.563 109.413 1.00 87.07  ? 103 CYS B N   1 
ATOM   566  C  CA  . CYS A 1 110 ? 180.785 198.083 110.742 1.00 88.97  ? 103 CYS B CA  1 
ATOM   567  C  C   . CYS A 1 110 ? 180.955 196.953 111.751 1.00 86.89  ? 103 CYS B C   1 
ATOM   568  O  O   . CYS A 1 110 ? 181.235 195.805 111.400 1.00 86.73  ? 103 CYS B O   1 
ATOM   569  C  CB  . CYS A 1 110 ? 179.392 198.704 110.819 1.00 92.45  ? 103 CYS B CB  1 
ATOM   570  S  SG  . CYS A 1 110 ? 178.827 199.442 109.269 1.00 107.92 ? 103 CYS B SG  1 
ATOM   571  N  N   . SER A 1 111 ? 180.791 197.278 113.030 1.00 87.64  ? 104 SER B N   1 
ATOM   572  C  CA  . SER A 1 111 ? 180.866 196.238 114.045 1.00 90.66  ? 104 SER B CA  1 
ATOM   573  C  C   . SER A 1 111 ? 179.776 195.189 113.861 1.00 94.86  ? 104 SER B C   1 
ATOM   574  O  O   . SER A 1 111 ? 179.945 194.050 114.306 1.00 95.47  ? 104 SER B O   1 
ATOM   575  C  CB  . SER A 1 111 ? 180.778 196.865 115.435 1.00 93.71  ? 104 SER B CB  1 
ATOM   576  O  OG  . SER A 1 111 ? 181.955 197.596 115.728 1.00 86.07  ? 104 SER B OG  1 
ATOM   577  N  N   . GLU A 1 112 ? 178.674 195.543 113.205 1.00 94.10  ? 105 GLU B N   1 
ATOM   578  C  CA  . GLU A 1 112 ? 177.612 194.586 112.952 1.00 93.14  ? 105 GLU B CA  1 
ATOM   579  C  C   . GLU A 1 112 ? 178.061 193.550 111.924 1.00 89.18  ? 105 GLU B C   1 
ATOM   580  O  O   . GLU A 1 112 ? 178.903 193.835 111.072 1.00 88.41  ? 105 GLU B O   1 
ATOM   581  C  CB  . GLU A 1 112 ? 176.361 195.296 112.448 1.00 94.85  ? 105 GLU B CB  1 
ATOM   582  C  CG  . GLU A 1 112 ? 175.523 195.942 113.533 1.00 100.08 ? 105 GLU B CG  1 
ATOM   583  C  CD  . GLU A 1 112 ? 174.138 196.314 113.046 1.00 105.65 ? 105 GLU B CD  1 
ATOM   584  O  OE1 . GLU A 1 112 ? 174.025 196.836 111.917 1.00 100.11 ? 105 GLU B OE1 1 
ATOM   585  O  OE2 . GLU A 1 112 ? 173.162 196.079 113.789 1.00 107.07 ? 105 GLU B OE2 1 
ATOM   586  N  N   . PRO A 1 113 ? 177.520 192.336 111.989 1.00 87.13  ? 106 PRO B N   1 
ATOM   587  C  CA  . PRO A 1 113 ? 177.856 191.328 110.979 1.00 83.55  ? 106 PRO B CA  1 
ATOM   588  C  C   . PRO A 1 113 ? 176.939 191.375 109.770 1.00 82.28  ? 106 PRO B C   1 
ATOM   589  O  O   . PRO A 1 113 ? 177.278 190.836 108.713 1.00 84.49  ? 106 PRO B O   1 
ATOM   590  C  CB  . PRO A 1 113 ? 177.704 190.012 111.744 1.00 83.90  ? 106 PRO B CB  1 
ATOM   591  C  CG  . PRO A 1 113 ? 176.647 190.299 112.745 1.00 85.14  ? 106 PRO B CG  1 
ATOM   592  C  CD  . PRO A 1 113 ? 176.729 191.766 113.092 1.00 87.02  ? 106 PRO B CD  1 
ATOM   593  N  N   . VAL A 1 114 ? 175.773 192.007 109.913 1.00 83.71  ? 107 VAL B N   1 
ATOM   594  C  CA  . VAL A 1 114 ? 174.842 192.105 108.791 1.00 85.45  ? 107 VAL B CA  1 
ATOM   595  C  C   . VAL A 1 114 ? 175.455 192.919 107.661 1.00 85.54  ? 107 VAL B C   1 
ATOM   596  O  O   . VAL A 1 114 ? 175.363 192.548 106.485 1.00 84.73  ? 107 VAL B O   1 
ATOM   597  C  CB  . VAL A 1 114 ? 173.502 192.702 109.257 1.00 85.55  ? 107 VAL B CB  1 
ATOM   598  C  CG1 . VAL A 1 114 ? 172.720 193.240 108.072 1.00 84.53  ? 107 VAL B CG1 1 
ATOM   599  C  CG2 . VAL A 1 114 ? 172.696 191.659 110.008 1.00 80.98  ? 107 VAL B CG2 1 
ATOM   600  N  N   . VAL A 1 115 ? 176.088 194.042 107.997 1.00 85.80  ? 108 VAL B N   1 
ATOM   601  C  CA  . VAL A 1 115 ? 176.772 194.833 106.983 1.00 82.93  ? 108 VAL B CA  1 
ATOM   602  C  C   . VAL A 1 115 ? 177.974 194.081 106.431 1.00 83.77  ? 108 VAL B C   1 
ATOM   603  O  O   . VAL A 1 115 ? 178.292 194.195 105.243 1.00 87.85  ? 108 VAL B O   1 
ATOM   604  C  CB  . VAL A 1 115 ? 177.174 196.201 107.562 1.00 84.05  ? 108 VAL B CB  1 
ATOM   605  C  CG1 . VAL A 1 115 ? 177.954 196.018 108.841 1.00 85.55  ? 108 VAL B CG1 1 
ATOM   606  C  CG2 . VAL A 1 115 ? 177.983 196.988 106.553 1.00 86.14  ? 108 VAL B CG2 1 
ATOM   607  N  N   . ALA A 1 116 ? 178.653 193.296 107.266 1.00 82.42  ? 109 ALA B N   1 
ATOM   608  C  CA  . ALA A 1 116 ? 179.881 192.629 106.858 1.00 81.65  ? 109 ALA B CA  1 
ATOM   609  C  C   . ALA A 1 116 ? 179.651 191.355 106.059 1.00 81.36  ? 109 ALA B C   1 
ATOM   610  O  O   . ALA A 1 116 ? 180.601 190.853 105.451 1.00 80.14  ? 109 ALA B O   1 
ATOM   611  C  CB  . ALA A 1 116 ? 180.725 192.293 108.083 1.00 78.74  ? 109 ALA B CB  1 
ATOM   612  N  N   . MET A 1 117 ? 178.436 190.810 106.056 1.00 81.29  ? 110 MET B N   1 
ATOM   613  C  CA  . MET A 1 117 ? 178.196 189.575 105.318 1.00 78.85  ? 110 MET B CA  1 
ATOM   614  C  C   . MET A 1 117 ? 178.256 189.806 103.814 1.00 79.64  ? 110 MET B C   1 
ATOM   615  O  O   . MET A 1 117 ? 178.711 188.935 103.066 1.00 81.84  ? 110 MET B O   1 
ATOM   616  C  CB  . MET A 1 117 ? 176.851 188.976 105.718 1.00 78.11  ? 110 MET B CB  1 
ATOM   617  C  CG  . MET A 1 117 ? 176.924 188.066 106.925 1.00 79.15  ? 110 MET B CG  1 
ATOM   618  S  SD  . MET A 1 117 ? 178.449 187.113 106.979 1.00 94.83  ? 110 MET B SD  1 
ATOM   619  C  CE  . MET A 1 117 ? 177.942 185.619 106.140 1.00 75.23  ? 110 MET B CE  1 
ATOM   620  N  N   . LYS A 1 118 ? 177.789 190.964 103.353 1.00 77.74  ? 111 LYS B N   1 
ATOM   621  C  CA  . LYS A 1 118 ? 177.821 191.260 101.922 1.00 81.81  ? 111 LYS B CA  1 
ATOM   622  C  C   . LYS A 1 118 ? 179.234 191.293 101.349 1.00 83.70  ? 111 LYS B C   1 
ATOM   623  O  O   . LYS A 1 118 ? 179.443 190.732 100.259 1.00 86.57  ? 111 LYS B O   1 
ATOM   624  C  CB  . LYS A 1 118 ? 177.073 192.570 101.657 1.00 82.71  ? 111 LYS B CB  1 
ATOM   625  C  CG  . LYS A 1 118 ? 176.338 192.604 100.337 1.00 88.48  ? 111 LYS B CG  1 
ATOM   626  C  CD  . LYS A 1 118 ? 175.044 193.385 100.460 1.00 96.11  ? 111 LYS B CD  1 
ATOM   627  C  CE  . LYS A 1 118 ? 174.098 192.734 101.450 1.00 95.25  ? 111 LYS B CE  1 
ATOM   628  N  NZ  . LYS A 1 118 ? 173.745 191.350 101.043 1.00 90.75  ? 111 LYS B NZ  1 
ATOM   629  N  N   . PRO A 1 119 ? 180.227 191.934 101.981 1.00 77.84  ? 112 PRO B N   1 
ATOM   630  C  CA  . PRO A 1 119 ? 181.591 191.847 101.436 1.00 75.53  ? 112 PRO B CA  1 
ATOM   631  C  C   . PRO A 1 119 ? 182.126 190.430 101.334 1.00 78.36  ? 112 PRO B C   1 
ATOM   632  O  O   . PRO A 1 119 ? 182.843 190.124 100.378 1.00 79.83  ? 112 PRO B O   1 
ATOM   633  C  CB  . PRO A 1 119 ? 182.406 192.693 102.418 1.00 69.51  ? 112 PRO B CB  1 
ATOM   634  C  CG  . PRO A 1 119 ? 181.445 193.683 102.912 1.00 73.80  ? 112 PRO B CG  1 
ATOM   635  C  CD  . PRO A 1 119 ? 180.150 192.948 103.046 1.00 74.45  ? 112 PRO B CD  1 
ATOM   636  N  N   . SER A 1 120 ? 181.808 189.549 102.285 1.00 77.47  ? 113 SER B N   1 
ATOM   637  C  CA  . SER A 1 120 ? 182.275 188.169 102.180 1.00 75.36  ? 113 SER B CA  1 
ATOM   638  C  C   . SER A 1 120 ? 181.652 187.462 100.982 1.00 75.61  ? 113 SER B C   1 
ATOM   639  O  O   . SER A 1 120 ? 182.341 186.744 100.243 1.00 77.82  ? 113 SER B O   1 
ATOM   640  C  CB  . SER A 1 120 ? 181.967 187.414 103.471 1.00 72.67  ? 113 SER B CB  1 
ATOM   641  O  OG  . SER A 1 120 ? 182.211 188.227 104.602 1.00 70.46  ? 113 SER B OG  1 
ATOM   642  N  N   . LEU A 1 121 ? 180.351 187.654 100.773 1.00 75.01  ? 114 LEU B N   1 
ATOM   643  C  CA  . LEU A 1 121 ? 179.696 187.050 99.621  1.00 76.66  ? 114 LEU B CA  1 
ATOM   644  C  C   . LEU A 1 121 ? 180.265 187.602 98.322  1.00 80.10  ? 114 LEU B C   1 
ATOM   645  O  O   . LEU A 1 121 ? 180.432 186.863 97.347  1.00 86.22  ? 114 LEU B O   1 
ATOM   646  C  CB  . LEU A 1 121 ? 178.188 187.279 99.695  1.00 79.35  ? 114 LEU B CB  1 
ATOM   647  C  CG  . LEU A 1 121 ? 177.366 186.169 100.351 1.00 80.25  ? 114 LEU B CG  1 
ATOM   648  C  CD1 . LEU A 1 121 ? 177.666 186.078 101.833 1.00 76.96  ? 114 LEU B CD1 1 
ATOM   649  C  CD2 . LEU A 1 121 ? 175.886 186.400 100.135 1.00 81.82  ? 114 LEU B CD2 1 
ATOM   650  N  N   . MET A 1 122 ? 180.570 188.901 98.287  1.00 77.32  ? 115 MET B N   1 
ATOM   651  C  CA  . MET A 1 122 ? 181.238 189.460 97.118  1.00 79.52  ? 115 MET B CA  1 
ATOM   652  C  C   . MET A 1 122 ? 182.644 188.899 96.958  1.00 81.63  ? 115 MET B C   1 
ATOM   653  O  O   . MET A 1 122 ? 183.160 188.831 95.838  1.00 83.28  ? 115 MET B O   1 
ATOM   654  C  CB  . MET A 1 122 ? 181.284 190.983 97.211  1.00 82.36  ? 115 MET B CB  1 
ATOM   655  C  CG  . MET A 1 122 ? 181.061 191.685 95.887  1.00 87.90  ? 115 MET B CG  1 
ATOM   656  S  SD  . MET A 1 122 ? 181.220 193.479 95.997  1.00 115.15 ? 115 MET B SD  1 
ATOM   657  C  CE  . MET A 1 122 ? 180.236 193.834 97.450  1.00 95.78  ? 115 MET B CE  1 
ATOM   658  N  N   . PHE A 1 123 ? 183.285 188.522 98.065  1.00 78.16  ? 116 PHE B N   1 
ATOM   659  C  CA  . PHE A 1 123 ? 184.593 187.881 97.993  1.00 75.29  ? 116 PHE B CA  1 
ATOM   660  C  C   . PHE A 1 123 ? 184.503 186.525 97.315  1.00 76.53  ? 116 PHE B C   1 
ATOM   661  O  O   . PHE A 1 123 ? 185.319 186.194 96.450  1.00 78.04  ? 116 PHE B O   1 
ATOM   662  C  CB  . PHE A 1 123 ? 185.181 187.722 99.394  1.00 68.81  ? 116 PHE B CB  1 
ATOM   663  C  CG  . PHE A 1 123 ? 185.831 188.956 99.923  1.00 68.21  ? 116 PHE B CG  1 
ATOM   664  C  CD1 . PHE A 1 123 ? 186.318 189.918 99.066  1.00 70.90  ? 116 PHE B CD1 1 
ATOM   665  C  CD2 . PHE A 1 123 ? 185.963 189.150 101.282 1.00 67.70  ? 116 PHE B CD2 1 
ATOM   666  C  CE1 . PHE A 1 123 ? 186.918 191.052 99.554  1.00 68.48  ? 116 PHE B CE1 1 
ATOM   667  C  CE2 . PHE A 1 123 ? 186.562 190.280 101.773 1.00 68.02  ? 116 PHE B CE2 1 
ATOM   668  C  CZ  . PHE A 1 123 ? 187.040 191.233 100.909 1.00 68.05  ? 116 PHE B CZ  1 
ATOM   669  N  N   . LEU A 1 124 ? 183.518 185.721 97.695  1.00 76.11  ? 117 LEU B N   1 
ATOM   670  C  CA  . LEU A 1 124 ? 183.482 184.356 97.185  1.00 71.47  ? 117 LEU B CA  1 
ATOM   671  C  C   . LEU A 1 124 ? 182.890 184.244 95.787  1.00 70.74  ? 117 LEU B C   1 
ATOM   672  O  O   . LEU A 1 124 ? 182.902 183.150 95.221  1.00 76.60  ? 117 LEU B O   1 
ATOM   673  C  CB  . LEU A 1 124 ? 182.708 183.442 98.135  1.00 75.80  ? 117 LEU B CB  1 
ATOM   674  C  CG  . LEU A 1 124 ? 183.557 182.735 99.193  1.00 75.56  ? 117 LEU B CG  1 
ATOM   675  C  CD1 . LEU A 1 124 ? 184.382 181.658 98.524  1.00 74.55  ? 117 LEU B CD1 1 
ATOM   676  C  CD2 . LEU A 1 124 ? 184.442 183.685 99.972  1.00 71.96  ? 117 LEU B CD2 1 
ATOM   677  N  N   . ALA A 1 125 ? 182.371 185.324 95.219  1.00 73.30  ? 118 ALA B N   1 
ATOM   678  C  CA  . ALA A 1 125 ? 181.855 185.254 93.862  1.00 78.81  ? 118 ALA B CA  1 
ATOM   679  C  C   . ALA A 1 125 ? 182.997 185.107 92.866  1.00 84.80  ? 118 ALA B C   1 
ATOM   680  O  O   . ALA A 1 125 ? 184.116 185.568 93.098  1.00 87.69  ? 118 ALA B O   1 
ATOM   681  C  CB  . ALA A 1 125 ? 181.030 186.497 93.538  1.00 83.34  ? 118 ALA B CB  1 
ATOM   682  N  N   . LYS A 1 126 ? 182.705 184.451 91.746  1.00 86.19  ? 119 LYS B N   1 
ATOM   683  C  CA  . LYS A 1 126 ? 183.709 184.240 90.714  1.00 89.34  ? 119 LYS B CA  1 
ATOM   684  C  C   . LYS A 1 126 ? 184.143 185.568 90.105  1.00 92.53  ? 119 LYS B C   1 
ATOM   685  O  O   . LYS A 1 126 ? 183.374 186.529 90.042  1.00 94.51  ? 119 LYS B O   1 
ATOM   686  C  CB  . LYS A 1 126 ? 183.165 183.317 89.627  1.00 92.99  ? 119 LYS B CB  1 
ATOM   687  C  CG  . LYS A 1 126 ? 184.210 182.769 88.674  1.00 94.53  ? 119 LYS B CG  1 
ATOM   688  C  CD  . LYS A 1 126 ? 183.594 181.755 87.722  1.00 94.17  ? 119 LYS B CD  1 
ATOM   689  C  CE  . LYS A 1 126 ? 184.137 181.910 86.313  1.00 95.86  ? 119 LYS B CE  1 
ATOM   690  N  NZ  . LYS A 1 126 ? 185.521 182.453 86.309  1.00 100.18 ? 119 LYS B NZ  1 
ATOM   691  N  N   . ALA A 1 127 ? 185.399 185.616 89.666  1.00 91.17  ? 120 ALA B N   1 
ATOM   692  C  CA  . ALA A 1 127 ? 185.942 186.839 89.092  1.00 94.30  ? 120 ALA B CA  1 
ATOM   693  C  C   . ALA A 1 127 ? 185.193 187.216 87.822  1.00 99.36  ? 120 ALA B C   1 
ATOM   694  O  O   . ALA A 1 127 ? 184.941 186.375 86.955  1.00 103.45 ? 120 ALA B O   1 
ATOM   695  C  CB  . ALA A 1 127 ? 187.430 186.670 88.789  1.00 91.65  ? 120 ALA B CB  1 
ATOM   696  N  N   . GLY A 1 128 ? 184.846 188.493 87.712  1.00 97.72  ? 121 GLY B N   1 
ATOM   697  C  CA  . GLY A 1 128 ? 184.137 188.992 86.555  1.00 101.09 ? 121 GLY B CA  1 
ATOM   698  C  C   . GLY A 1 128 ? 182.634 188.842 86.601  1.00 102.85 ? 121 GLY B C   1 
ATOM   699  O  O   . GLY A 1 128 ? 181.958 189.275 85.660  1.00 106.31 ? 121 GLY B O   1 
ATOM   700  N  N   . SER A 1 129 ? 182.087 188.249 87.658  1.00 99.24  ? 122 SER B N   1 
ATOM   701  C  CA  . SER A 1 129 ? 180.650 188.092 87.798  1.00 99.62  ? 122 SER B CA  1 
ATOM   702  C  C   . SER A 1 129 ? 180.248 188.461 89.216  1.00 99.95  ? 122 SER B C   1 
ATOM   703  O  O   . SER A 1 129 ? 181.059 188.397 90.142  1.00 100.29 ? 122 SER B O   1 
ATOM   704  C  CB  . SER A 1 129 ? 180.199 186.663 87.477  1.00 96.50  ? 122 SER B CB  1 
ATOM   705  O  OG  . SER A 1 129 ? 178.788 186.566 87.482  1.00 90.11  ? 122 SER B OG  1 
ATOM   706  N  N   . ARG A 1 130 ? 178.988 188.855 89.375  1.00 99.17  ? 123 ARG B N   1 
ATOM   707  C  CA  . ARG A 1 130 ? 178.452 189.254 90.668  1.00 98.59  ? 123 ARG B CA  1 
ATOM   708  C  C   . ARG A 1 130 ? 177.628 188.156 91.326  1.00 96.29  ? 123 ARG B C   1 
ATOM   709  O  O   . ARG A 1 130 ? 176.945 188.420 92.320  1.00 93.77  ? 123 ARG B O   1 
ATOM   710  C  CB  . ARG A 1 130 ? 177.609 190.521 90.519  1.00 102.39 ? 123 ARG B CB  1 
ATOM   711  C  CG  . ARG A 1 130 ? 176.828 190.592 89.219  1.00 106.06 ? 123 ARG B CG  1 
ATOM   712  C  CD  . ARG A 1 130 ? 176.145 191.939 89.057  1.00 110.33 ? 123 ARG B CD  1 
ATOM   713  N  NE  . ARG A 1 130 ? 175.043 192.112 89.995  1.00 114.93 ? 123 ARG B NE  1 
ATOM   714  C  CZ  . ARG A 1 130 ? 174.265 193.184 90.047  1.00 112.31 ? 123 ARG B CZ  1 
ATOM   715  N  NH1 . ARG A 1 130 ? 174.440 194.205 89.225  1.00 107.95 ? 123 ARG B NH1 1 
ATOM   716  N  NH2 . ARG A 1 130 ? 173.286 193.232 90.945  1.00 104.24 ? 123 ARG B NH2 1 
ATOM   717  N  N   . ASP A 1 131 ? 177.677 186.935 90.803  1.00 95.06  ? 124 ASP B N   1 
ATOM   718  C  CA  . ASP A 1 131 ? 176.871 185.832 91.302  1.00 92.17  ? 124 ASP B CA  1 
ATOM   719  C  C   . ASP A 1 131 ? 177.760 184.782 91.952  1.00 89.49  ? 124 ASP B C   1 
ATOM   720  O  O   . ASP A 1 131 ? 178.799 184.408 91.401  1.00 89.48  ? 124 ASP B O   1 
ATOM   721  C  CB  . ASP A 1 131 ? 176.062 185.192 90.172  1.00 90.07  ? 124 ASP B CB  1 
ATOM   722  C  CG  . ASP A 1 131 ? 174.992 186.112 89.629  1.00 93.91  ? 124 ASP B CG  1 
ATOM   723  O  OD1 . ASP A 1 131 ? 174.953 187.289 90.038  1.00 94.44  ? 124 ASP B OD1 1 
ATOM   724  O  OD2 . ASP A 1 131 ? 174.187 185.657 88.790  1.00 96.75  ? 124 ASP B OD2 1 
ATOM   725  N  N   . ILE A 1 132 ? 177.342 184.304 93.119  1.00 87.79  ? 125 ILE B N   1 
ATOM   726  C  CA  . ILE A 1 132 ? 178.035 183.243 93.840  1.00 86.68  ? 125 ILE B CA  1 
ATOM   727  C  C   . ILE A 1 132 ? 177.187 181.984 93.755  1.00 85.83  ? 125 ILE B C   1 
ATOM   728  O  O   . ILE A 1 132 ? 176.023 181.981 94.171  1.00 84.14  ? 125 ILE B O   1 
ATOM   729  C  CB  . ILE A 1 132 ? 178.303 183.626 95.302  1.00 86.36  ? 125 ILE B CB  1 
ATOM   730  C  CG1 . ILE A 1 132 ? 178.601 182.380 96.132  1.00 81.50  ? 125 ILE B CG1 1 
ATOM   731  C  CG2 . ILE A 1 132 ? 177.123 184.368 95.887  1.00 85.44  ? 125 ILE B CG2 1 
ATOM   732  C  CD1 . ILE A 1 132 ? 178.966 182.685 97.561  1.00 75.26  ? 125 ILE B CD1 1 
ATOM   733  N  N   . ALA A 1 133 ? 177.765 180.918 93.214  1.00 89.64  ? 126 ALA B N   1 
ATOM   734  C  CA  . ALA A 1 133 ? 177.058 179.653 93.125  1.00 92.91  ? 126 ALA B CA  1 
ATOM   735  C  C   . ALA A 1 133 ? 177.078 178.940 94.471  1.00 90.20  ? 126 ALA B C   1 
ATOM   736  O  O   . ALA A 1 133 ? 177.878 179.250 95.354  1.00 89.72  ? 126 ALA B O   1 
ATOM   737  C  CB  . ALA A 1 133 ? 177.679 178.760 92.053  1.00 95.32  ? 126 ALA B CB  1 
ATOM   738  N  N   . ALA A 1 134 ? 176.178 177.972 94.622  1.00 89.53  ? 127 ALA B N   1 
ATOM   739  C  CA  . ALA A 1 134 ? 176.122 177.134 95.816  1.00 89.04  ? 127 ALA B CA  1 
ATOM   740  C  C   . ALA A 1 134 ? 176.392 175.698 95.387  1.00 93.89  ? 127 ALA B C   1 
ATOM   741  O  O   . ALA A 1 134 ? 175.470 174.909 95.183  1.00 98.56  ? 127 ALA B O   1 
ATOM   742  C  CB  . ALA A 1 134 ? 174.784 177.271 96.514  1.00 84.22  ? 127 ALA B CB  1 
ATOM   743  N  N   . TYR A 1 135 ? 177.669 175.354 95.274  1.00 94.01  ? 128 TYR B N   1 
ATOM   744  C  CA  . TYR A 1 135 ? 178.043 174.025 94.825  1.00 98.99  ? 128 TYR B CA  1 
ATOM   745  C  C   . TYR A 1 135 ? 178.033 173.044 95.994  1.00 100.26 ? 128 TYR B C   1 
ATOM   746  O  O   . TYR A 1 135 ? 177.782 173.406 97.146  1.00 96.61  ? 128 TYR B O   1 
ATOM   747  C  CB  . TYR A 1 135 ? 179.416 174.052 94.157  1.00 98.14  ? 128 TYR B CB  1 
ATOM   748  C  CG  . TYR A 1 135 ? 179.440 174.800 92.846  1.00 95.17  ? 128 TYR B CG  1 
ATOM   749  C  CD1 . TYR A 1 135 ? 178.448 174.609 91.899  1.00 95.59  ? 128 TYR B CD1 1 
ATOM   750  C  CD2 . TYR A 1 135 ? 180.454 175.699 92.557  1.00 94.56  ? 128 TYR B CD2 1 
ATOM   751  C  CE1 . TYR A 1 135 ? 178.466 175.290 90.702  1.00 96.93  ? 128 TYR B CE1 1 
ATOM   752  C  CE2 . TYR A 1 135 ? 180.480 176.382 91.363  1.00 93.77  ? 128 TYR B CE2 1 
ATOM   753  C  CZ  . TYR A 1 135 ? 179.485 176.176 90.440  1.00 93.94  ? 128 TYR B CZ  1 
ATOM   754  O  OH  . TYR A 1 135 ? 179.509 176.859 89.249  1.00 95.19  ? 128 TYR B OH  1 
ATOM   755  N  N   . CYS A 1 136 ? 178.298 171.776 95.678  1.00 104.08 ? 129 CYS B N   1 
ATOM   756  C  CA  . CYS A 1 136 ? 178.287 170.739 96.704  1.00 110.06 ? 129 CYS B CA  1 
ATOM   757  C  C   . CYS A 1 136 ? 179.383 170.968 97.735  1.00 107.00 ? 129 CYS B C   1 
ATOM   758  O  O   . CYS A 1 136 ? 179.162 170.803 98.939  1.00 101.14 ? 129 CYS B O   1 
ATOM   759  C  CB  . CYS A 1 136 ? 178.437 169.362 96.061  1.00 119.44 ? 129 CYS B CB  1 
ATOM   760  S  SG  . CYS A 1 136 ? 178.485 168.000 97.246  1.00 137.57 ? 129 CYS B SG  1 
ATOM   761  N  N   . ASN A 1 137 ? 180.576 171.344 97.284  1.00 110.76 ? 130 ASN B N   1 
ATOM   762  C  CA  . ASN A 1 137 ? 181.709 171.507 98.183  1.00 108.59 ? 130 ASN B CA  1 
ATOM   763  C  C   . ASN A 1 137 ? 182.582 172.651 97.678  1.00 104.11 ? 130 ASN B C   1 
ATOM   764  O  O   . ASN A 1 137 ? 182.224 173.374 96.745  1.00 104.67 ? 130 ASN B O   1 
ATOM   765  C  CB  . ASN A 1 137 ? 182.495 170.198 98.306  1.00 114.15 ? 130 ASN B CB  1 
ATOM   766  C  CG  . ASN A 1 137 ? 182.654 169.484 96.979  1.00 116.69 ? 130 ASN B CG  1 
ATOM   767  O  OD1 . ASN A 1 137 ? 182.879 170.108 95.944  1.00 110.17 ? 130 ASN B OD1 1 
ATOM   768  N  ND2 . ASN A 1 137 ? 182.547 168.166 97.009  1.00 122.12 ? 130 ASN B ND2 1 
ATOM   769  N  N   . TYR A 1 138 ? 183.749 172.804 98.302  1.00 96.65  ? 131 TYR B N   1 
ATOM   770  C  CA  . TYR A 1 138 ? 184.629 173.926 98.002  1.00 93.66  ? 131 TYR B CA  1 
ATOM   771  C  C   . TYR A 1 138 ? 185.379 173.757 96.688  1.00 97.26  ? 131 TYR B C   1 
ATOM   772  O  O   . TYR A 1 138 ? 185.755 174.756 96.069  1.00 97.16  ? 131 TYR B O   1 
ATOM   773  C  CB  . TYR A 1 138 ? 185.635 174.112 99.136  1.00 87.19  ? 131 TYR B CB  1 
ATOM   774  C  CG  . TYR A 1 138 ? 186.747 173.091 99.122  1.00 94.56  ? 131 TYR B CG  1 
ATOM   775  C  CD1 . TYR A 1 138 ? 186.522 171.787 99.535  1.00 100.56 ? 131 TYR B CD1 1 
ATOM   776  C  CD2 . TYR A 1 138 ? 188.021 173.429 98.693  1.00 94.76  ? 131 TYR B CD2 1 
ATOM   777  C  CE1 . TYR A 1 138 ? 187.534 170.851 99.521  1.00 102.28 ? 131 TYR B CE1 1 
ATOM   778  C  CE2 . TYR A 1 138 ? 189.036 172.499 98.676  1.00 96.77  ? 131 TYR B CE2 1 
ATOM   779  C  CZ  . TYR A 1 138 ? 188.789 171.214 99.092  1.00 99.79  ? 131 TYR B CZ  1 
ATOM   780  O  OH  . TYR A 1 138 ? 189.805 170.288 99.072  1.00 100.08 ? 131 TYR B OH  1 
ATOM   781  N  N   . THR A 1 139 ? 185.613 172.518 96.251  1.00 100.72 ? 132 THR B N   1 
ATOM   782  C  CA  . THR A 1 139 ? 186.514 172.279 95.127  1.00 99.61  ? 132 THR B CA  1 
ATOM   783  C  C   . THR A 1 139 ? 186.008 172.877 93.823  1.00 100.42 ? 132 THR B C   1 
ATOM   784  O  O   . THR A 1 139 ? 186.801 173.056 92.893  1.00 97.67  ? 132 THR B O   1 
ATOM   785  C  CB  . THR A 1 139 ? 186.741 170.780 94.935  1.00 97.25  ? 132 THR B CB  1 
ATOM   786  O  OG1 . THR A 1 139 ? 185.491 170.089 95.027  1.00 101.72 ? 132 THR B OG1 1 
ATOM   787  C  CG2 . THR A 1 139 ? 187.680 170.246 95.996  1.00 90.75  ? 132 THR B CG2 1 
ATOM   788  N  N   . GLN A 1 140 ? 184.720 173.190 93.730  1.00 99.38  ? 133 GLN B N   1 
ATOM   789  C  CA  . GLN A 1 140 ? 184.140 173.705 92.499  1.00 99.29  ? 133 GLN B CA  1 
ATOM   790  C  C   . GLN A 1 140 ? 184.096 175.226 92.442  1.00 98.87  ? 133 GLN B C   1 
ATOM   791  O  O   . GLN A 1 140 ? 183.564 175.777 91.474  1.00 100.15 ? 133 GLN B O   1 
ATOM   792  C  CB  . GLN A 1 140 ? 182.728 173.143 92.312  1.00 102.16 ? 133 GLN B CB  1 
ATOM   793  C  CG  . GLN A 1 140 ? 182.587 171.686 92.708  1.00 106.40 ? 133 GLN B CG  1 
ATOM   794  C  CD  . GLN A 1 140 ? 181.214 171.131 92.399  1.00 110.34 ? 133 GLN B CD  1 
ATOM   795  O  OE1 . GLN A 1 140 ? 180.650 171.400 91.339  1.00 106.32 ? 133 GLN B OE1 1 
ATOM   796  N  NE2 . GLN A 1 140 ? 180.666 170.354 93.326  1.00 108.35 ? 133 GLN B NE2 1 
ATOM   797  N  N   . TYR A 1 141 ? 184.634 175.915 93.441  1.00 97.92  ? 134 TYR B N   1 
ATOM   798  C  CA  . TYR A 1 141 ? 184.611 177.369 93.474  1.00 92.91  ? 134 TYR B CA  1 
ATOM   799  C  C   . TYR A 1 141 ? 185.894 177.940 92.888  1.00 93.64  ? 134 TYR B C   1 
ATOM   800  O  O   . TYR A 1 141 ? 186.962 177.327 92.960  1.00 95.27  ? 134 TYR B O   1 
ATOM   801  C  CB  . TYR A 1 141 ? 184.439 177.873 94.905  1.00 87.67  ? 134 TYR B CB  1 
ATOM   802  C  CG  . TYR A 1 141 ? 183.041 177.712 95.436  1.00 90.33  ? 134 TYR B CG  1 
ATOM   803  C  CD1 . TYR A 1 141 ? 182.640 176.522 96.020  1.00 93.28  ? 134 TYR B CD1 1 
ATOM   804  C  CD2 . TYR A 1 141 ? 182.124 178.745 95.357  1.00 87.76  ? 134 TYR B CD2 1 
ATOM   805  C  CE1 . TYR A 1 141 ? 181.366 176.363 96.507  1.00 92.14  ? 134 TYR B CE1 1 
ATOM   806  C  CE2 . TYR A 1 141 ? 180.846 178.594 95.842  1.00 90.91  ? 134 TYR B CE2 1 
ATOM   807  C  CZ  . TYR A 1 141 ? 180.473 177.399 96.416  1.00 91.99  ? 134 TYR B CZ  1 
ATOM   808  O  OH  . TYR A 1 141 ? 179.201 177.232 96.907  1.00 92.44  ? 134 TYR B OH  1 
ATOM   809  N  N   . GLN A 1 142 ? 185.778 179.128 92.303  1.00 91.62  ? 135 GLN B N   1 
ATOM   810  C  CA  . GLN A 1 142 ? 186.925 179.885 91.804  1.00 88.77  ? 135 GLN B CA  1 
ATOM   811  C  C   . GLN A 1 142 ? 186.817 181.317 92.310  1.00 84.42  ? 135 GLN B C   1 
ATOM   812  O  O   . GLN A 1 142 ? 186.502 182.238 91.549  1.00 88.30  ? 135 GLN B O   1 
ATOM   813  C  CB  . GLN A 1 142 ? 186.990 179.841 90.278  1.00 92.93  ? 135 GLN B CB  1 
ATOM   814  C  CG  . GLN A 1 142 ? 187.578 178.558 89.718  1.00 98.63  ? 135 GLN B CG  1 
ATOM   815  C  CD  . GLN A 1 142 ? 189.080 178.471 89.898  1.00 103.29 ? 135 GLN B CD  1 
ATOM   816  O  OE1 . GLN A 1 142 ? 189.658 177.385 89.853  1.00 102.24 ? 135 GLN B OE1 1 
ATOM   817  N  NE2 . GLN A 1 142 ? 189.721 179.615 90.108  1.00 100.15 ? 135 GLN B NE2 1 
ATOM   818  N  N   . PRO A 1 143 ? 187.074 181.539 93.596  1.00 77.16  ? 136 PRO B N   1 
ATOM   819  C  CA  . PRO A 1 143 ? 186.838 182.863 94.175  1.00 72.75  ? 136 PRO B CA  1 
ATOM   820  C  C   . PRO A 1 143 ? 187.762 183.908 93.579  1.00 74.19  ? 136 PRO B C   1 
ATOM   821  O  O   . PRO A 1 143 ? 188.850 183.604 93.090  1.00 76.59  ? 136 PRO B O   1 
ATOM   822  C  CB  . PRO A 1 143 ? 187.124 182.657 95.665  1.00 75.06  ? 136 PRO B CB  1 
ATOM   823  C  CG  . PRO A 1 143 ? 187.071 181.186 95.875  1.00 79.48  ? 136 PRO B CG  1 
ATOM   824  C  CD  . PRO A 1 143 ? 187.549 180.580 94.602  1.00 82.26  ? 136 PRO B CD  1 
ATOM   825  N  N   . ARG A 1 144 ? 187.303 185.157 93.614  1.00 76.91  ? 137 ARG B N   1 
ATOM   826  C  CA  . ARG A 1 144 ? 188.060 186.265 93.051  1.00 78.29  ? 137 ARG B CA  1 
ATOM   827  C  C   . ARG A 1 144 ? 189.168 186.765 93.968  1.00 74.17  ? 137 ARG B C   1 
ATOM   828  O  O   . ARG A 1 144 ? 190.053 187.485 93.498  1.00 72.94  ? 137 ARG B O   1 
ATOM   829  C  CB  . ARG A 1 144 ? 187.115 187.418 92.710  1.00 78.16  ? 137 ARG B CB  1 
ATOM   830  C  CG  . ARG A 1 144 ? 186.922 188.417 93.827  1.00 77.18  ? 137 ARG B CG  1 
ATOM   831  C  CD  . ARG A 1 144 ? 186.408 189.737 93.291  1.00 84.46  ? 137 ARG B CD  1 
ATOM   832  N  NE  . ARG A 1 144 ? 184.971 189.700 93.055  1.00 94.21  ? 137 ARG B NE  1 
ATOM   833  C  CZ  . ARG A 1 144 ? 184.318 190.554 92.281  1.00 98.07  ? 137 ARG B CZ  1 
ATOM   834  N  NH1 . ARG A 1 144 ? 184.945 191.528 91.642  1.00 97.07  ? 137 ARG B NH1 1 
ATOM   835  N  NH2 . ARG A 1 144 ? 183.002 190.427 92.140  1.00 95.59  ? 137 ARG B NH2 1 
ATOM   836  N  N   . VAL A 1 145 ? 189.156 186.394 95.245  1.00 72.65  ? 138 VAL B N   1 
ATOM   837  C  CA  . VAL A 1 145 ? 190.141 186.858 96.214  1.00 71.50  ? 138 VAL B CA  1 
ATOM   838  C  C   . VAL A 1 145 ? 190.955 185.664 96.685  1.00 73.10  ? 138 VAL B C   1 
ATOM   839  O  O   . VAL A 1 145 ? 190.394 184.623 97.040  1.00 75.58  ? 138 VAL B O   1 
ATOM   840  C  CB  . VAL A 1 145 ? 189.478 187.569 97.406  1.00 69.92  ? 138 VAL B CB  1 
ATOM   841  C  CG1 . VAL A 1 145 ? 189.080 188.977 97.019  1.00 70.83  ? 138 VAL B CG1 1 
ATOM   842  C  CG2 . VAL A 1 145 ? 188.275 186.792 97.880  1.00 70.05  ? 138 VAL B CG2 1 
ATOM   843  N  N   . LEU A 1 146 ? 192.279 185.813 96.677  1.00 74.31  ? 139 LEU B N   1 
ATOM   844  C  CA  . LEU A 1 146 ? 193.150 184.722 97.098  1.00 69.62  ? 139 LEU B CA  1 
ATOM   845  C  C   . LEU A 1 146 ? 193.002 184.431 98.586  1.00 68.30  ? 139 LEU B C   1 
ATOM   846  O  O   . LEU A 1 146 ? 192.931 183.266 98.989  1.00 72.55  ? 139 LEU B O   1 
ATOM   847  C  CB  . LEU A 1 146 ? 194.598 185.061 96.760  1.00 70.49  ? 139 LEU B CB  1 
ATOM   848  C  CG  . LEU A 1 146 ? 195.682 184.269 97.476  1.00 68.78  ? 139 LEU B CG  1 
ATOM   849  C  CD1 . LEU A 1 146 ? 195.756 182.867 96.915  1.00 71.36  ? 139 LEU B CD1 1 
ATOM   850  C  CD2 . LEU A 1 146 ? 197.006 184.975 97.325  1.00 70.74  ? 139 LEU B CD2 1 
ATOM   851  N  N   . ALA A 1 147 ? 192.950 185.470 99.414  1.00 62.07  ? 140 ALA B N   1 
ATOM   852  C  CA  . ALA A 1 147 ? 192.825 185.314 100.856 1.00 56.12  ? 140 ALA B CA  1 
ATOM   853  C  C   . ALA A 1 147 ? 192.024 186.487 101.398 1.00 57.88  ? 140 ALA B C   1 
ATOM   854  O  O   . ALA A 1 147 ? 191.654 187.401 100.661 1.00 66.04  ? 140 ALA B O   1 
ATOM   855  C  CB  . ALA A 1 147 ? 194.197 185.222 101.521 1.00 55.54  ? 140 ALA B CB  1 
ATOM   856  N  N   . VAL A 1 148 ? 191.754 186.460 102.699 1.00 51.37  ? 141 VAL B N   1 
ATOM   857  C  CA  . VAL A 1 148 ? 190.979 187.503 103.360 1.00 49.22  ? 141 VAL B CA  1 
ATOM   858  C  C   . VAL A 1 148 ? 191.723 187.938 104.611 1.00 49.97  ? 141 VAL B C   1 
ATOM   859  O  O   . VAL A 1 148 ? 192.205 187.095 105.372 1.00 56.06  ? 141 VAL B O   1 
ATOM   860  C  CB  . VAL A 1 148 ? 189.563 187.020 103.723 1.00 49.90  ? 141 VAL B CB  1 
ATOM   861  C  CG1 . VAL A 1 148 ? 188.839 188.068 104.535 1.00 47.88  ? 141 VAL B CG1 1 
ATOM   862  C  CG2 . VAL A 1 148 ? 188.783 186.696 102.475 1.00 57.89  ? 141 VAL B CG2 1 
ATOM   863  N  N   . ILE A 1 149 ? 191.827 189.248 104.820 1.00 47.41  ? 142 ILE B N   1 
ATOM   864  C  CA  . ILE A 1 149 ? 192.372 189.791 106.059 1.00 47.42  ? 142 ILE B CA  1 
ATOM   865  C  C   . ILE A 1 149 ? 191.183 190.074 106.971 1.00 50.64  ? 142 ILE B C   1 
ATOM   866  O  O   . ILE A 1 149 ? 190.526 191.106 106.857 1.00 53.09  ? 142 ILE B O   1 
ATOM   867  C  CB  . ILE A 1 149 ? 193.215 191.038 105.813 1.00 48.39  ? 142 ILE B CB  1 
ATOM   868  C  CG1 . ILE A 1 149 ? 194.275 190.751 104.754 1.00 42.46  ? 142 ILE B CG1 1 
ATOM   869  C  CG2 . ILE A 1 149 ? 193.865 191.488 107.099 1.00 45.94  ? 142 ILE B CG2 1 
ATOM   870  C  CD1 . ILE A 1 149 ? 195.085 189.520 105.017 1.00 43.50  ? 142 ILE B CD1 1 
ATOM   871  N  N   . GLY A 1 150 ? 190.932 189.160 107.902 1.00 57.05  ? 143 GLY B N   1 
ATOM   872  C  CA  . GLY A 1 150 ? 189.685 189.084 108.623 1.00 58.81  ? 143 GLY B CA  1 
ATOM   873  C  C   . GLY A 1 150 ? 189.401 190.264 109.522 1.00 60.35  ? 143 GLY B C   1 
ATOM   874  O  O   . GLY A 1 150 ? 190.236 191.149 109.722 1.00 62.53  ? 143 GLY B O   1 
ATOM   875  N  N   . PRO A 1 151 ? 188.197 190.294 110.078 1.00 61.33  ? 144 PRO B N   1 
ATOM   876  C  CA  . PRO A 1 151 ? 187.770 191.454 110.860 1.00 65.10  ? 144 PRO B CA  1 
ATOM   877  C  C   . PRO A 1 151 ? 188.497 191.537 112.189 1.00 67.87  ? 144 PRO B C   1 
ATOM   878  O  O   . PRO A 1 151 ? 188.998 190.549 112.727 1.00 67.62  ? 144 PRO B O   1 
ATOM   879  C  CB  . PRO A 1 151 ? 186.271 191.216 111.067 1.00 68.20  ? 144 PRO B CB  1 
ATOM   880  C  CG  . PRO A 1 151 ? 185.916 190.052 110.182 1.00 66.83  ? 144 PRO B CG  1 
ATOM   881  C  CD  . PRO A 1 151 ? 187.157 189.261 110.016 1.00 61.53  ? 144 PRO B CD  1 
ATOM   882  N  N   . HIS A 1 152 ? 188.549 192.760 112.715 1.00 69.53  ? 145 HIS B N   1 
ATOM   883  C  CA  . HIS A 1 152 ? 189.166 192.983 114.015 1.00 73.37  ? 145 HIS B CA  1 
ATOM   884  C  C   . HIS A 1 152 ? 188.293 192.452 115.144 1.00 79.17  ? 145 HIS B C   1 
ATOM   885  O  O   . HIS A 1 152 ? 188.793 191.801 116.068 1.00 78.99  ? 145 HIS B O   1 
ATOM   886  C  CB  . HIS A 1 152 ? 189.442 194.469 114.206 1.00 70.20  ? 145 HIS B CB  1 
ATOM   887  C  CG  . HIS A 1 152 ? 190.045 194.803 115.530 1.00 74.62  ? 145 HIS B CG  1 
ATOM   888  N  ND1 . HIS A 1 152 ? 189.293 195.236 116.599 1.00 81.11  ? 145 HIS B ND1 1 
ATOM   889  C  CD2 . HIS A 1 152 ? 191.327 194.770 115.960 1.00 76.52  ? 145 HIS B CD2 1 
ATOM   890  C  CE1 . HIS A 1 152 ? 190.087 195.457 117.631 1.00 82.71  ? 145 HIS B CE1 1 
ATOM   891  N  NE2 . HIS A 1 152 ? 191.327 195.181 117.269 1.00 81.02  ? 145 HIS B NE2 1 
ATOM   892  N  N   . SER A 1 153 ? 186.991 192.718 115.089 1.00 81.05  ? 146 SER B N   1 
ATOM   893  C  CA  . SER A 1 153 ? 186.089 192.262 116.138 1.00 81.75  ? 146 SER B CA  1 
ATOM   894  C  C   . SER A 1 153 ? 185.998 190.744 116.133 1.00 77.78  ? 146 SER B C   1 
ATOM   895  O  O   . SER A 1 153 ? 185.988 190.111 115.076 1.00 77.96  ? 146 SER B O   1 
ATOM   896  C  CB  . SER A 1 153 ? 184.703 192.874 115.952 1.00 87.13  ? 146 SER B CB  1 
ATOM   897  O  OG  . SER A 1 153 ? 184.561 194.050 116.729 1.00 87.29  ? 146 SER B OG  1 
ATOM   898  N  N   . SER A 1 154 ? 185.932 190.158 117.328 1.00 72.21  ? 147 SER B N   1 
ATOM   899  C  CA  . SER A 1 154 ? 185.994 188.706 117.434 1.00 71.13  ? 147 SER B CA  1 
ATOM   900  C  C   . SER A 1 154 ? 184.680 188.036 117.052 1.00 76.96  ? 147 SER B C   1 
ATOM   901  O  O   . SER A 1 154 ? 184.693 186.942 116.484 1.00 79.52  ? 147 SER B O   1 
ATOM   902  C  CB  . SER A 1 154 ? 186.399 188.293 118.842 1.00 73.86  ? 147 SER B CB  1 
ATOM   903  O  OG  . SER A 1 154 ? 186.829 186.946 118.839 1.00 78.04  ? 147 SER B OG  1 
ATOM   904  N  N   . GLU A 1 155 ? 183.538 188.644 117.380 1.00 76.95  ? 148 GLU B N   1 
ATOM   905  C  CA  . GLU A 1 155 ? 182.265 188.060 116.965 1.00 77.74  ? 148 GLU B CA  1 
ATOM   906  C  C   . GLU A 1 155 ? 182.114 188.096 115.451 1.00 81.21  ? 148 GLU B C   1 
ATOM   907  O  O   . GLU A 1 155 ? 181.693 187.107 114.830 1.00 83.57  ? 148 GLU B O   1 
ATOM   908  C  CB  . GLU A 1 155 ? 181.107 188.787 117.643 1.00 78.10  ? 148 GLU B CB  1 
ATOM   909  C  CG  . GLU A 1 155 ? 180.889 188.371 119.087 1.00 89.74  ? 148 GLU B CG  1 
ATOM   910  C  CD  . GLU A 1 155 ? 181.455 189.367 120.078 1.00 98.66  ? 148 GLU B CD  1 
ATOM   911  O  OE1 . GLU A 1 155 ? 182.255 190.232 119.665 1.00 93.89  ? 148 GLU B OE1 1 
ATOM   912  O  OE2 . GLU A 1 155 ? 181.105 189.279 121.272 1.00 101.18 ? 148 GLU B OE2 1 
ATOM   913  N  N   . LEU A 1 156 ? 182.462 189.228 114.839 1.00 78.01  ? 149 LEU B N   1 
ATOM   914  C  CA  . LEU A 1 156 ? 182.482 189.301 113.386 1.00 76.77  ? 149 LEU B CA  1 
ATOM   915  C  C   . LEU A 1 156 ? 183.473 188.301 112.810 1.00 75.18  ? 149 LEU B C   1 
ATOM   916  O  O   . LEU A 1 156 ? 183.227 187.705 111.754 1.00 73.68  ? 149 LEU B O   1 
ATOM   917  C  CB  . LEU A 1 156 ? 182.823 190.721 112.946 1.00 72.37  ? 149 LEU B CB  1 
ATOM   918  C  CG  . LEU A 1 156 ? 182.680 190.986 111.454 1.00 76.07  ? 149 LEU B CG  1 
ATOM   919  C  CD1 . LEU A 1 156 ? 181.392 190.379 110.951 1.00 76.87  ? 149 LEU B CD1 1 
ATOM   920  C  CD2 . LEU A 1 156 ? 182.726 192.474 111.177 1.00 78.96  ? 149 LEU B CD2 1 
ATOM   921  N  N   . ALA A 1 157 ? 184.599 188.098 113.497 1.00 72.69  ? 150 ALA B N   1 
ATOM   922  C  CA  . ALA A 1 157 ? 185.568 187.106 113.051 1.00 68.43  ? 150 ALA B CA  1 
ATOM   923  C  C   . ALA A 1 157 ? 184.977 185.708 113.088 1.00 70.70  ? 150 ALA B C   1 
ATOM   924  O  O   . ALA A 1 157 ? 185.206 184.913 112.177 1.00 76.04  ? 150 ALA B O   1 
ATOM   925  C  CB  . ALA A 1 157 ? 186.829 187.174 113.906 1.00 71.66  ? 150 ALA B CB  1 
ATOM   926  N  N   . MET A 1 158 ? 184.215 185.386 114.134 1.00 71.86  ? 151 MET B N   1 
ATOM   927  C  CA  . MET A 1 158 ? 183.561 184.083 114.202 1.00 73.88  ? 151 MET B CA  1 
ATOM   928  C  C   . MET A 1 158 ? 182.585 183.898 113.054 1.00 76.16  ? 151 MET B C   1 
ATOM   929  O  O   . MET A 1 158 ? 182.558 182.842 112.411 1.00 78.80  ? 151 MET B O   1 
ATOM   930  C  CB  . MET A 1 158 ? 182.829 183.920 115.530 1.00 76.73  ? 151 MET B CB  1 
ATOM   931  C  CG  . MET A 1 158 ? 183.699 183.486 116.673 1.00 81.71  ? 151 MET B CG  1 
ATOM   932  S  SD  . MET A 1 158 ? 182.711 182.677 117.934 1.00 99.72  ? 151 MET B SD  1 
ATOM   933  C  CE  . MET A 1 158 ? 183.519 183.291 119.395 1.00 91.01  ? 151 MET B CE  1 
ATOM   934  N  N   . VAL A 1 159 ? 181.768 184.916 112.786 1.00 74.30  ? 152 VAL B N   1 
ATOM   935  C  CA  . VAL A 1 159 ? 180.784 184.801 111.712 1.00 73.56  ? 152 VAL B CA  1 
ATOM   936  C  C   . VAL A 1 159 ? 181.482 184.589 110.372 1.00 75.05  ? 152 VAL B C   1 
ATOM   937  O  O   . VAL A 1 159 ? 181.162 183.659 109.618 1.00 75.92  ? 152 VAL B O   1 
ATOM   938  C  CB  . VAL A 1 159 ? 179.875 186.040 111.683 1.00 72.07  ? 152 VAL B CB  1 
ATOM   939  C  CG1 . VAL A 1 159 ? 178.874 185.925 110.557 1.00 75.62  ? 152 VAL B CG1 1 
ATOM   940  C  CG2 . VAL A 1 159 ? 179.170 186.202 113.010 1.00 73.82  ? 152 VAL B CG2 1 
ATOM   941  N  N   . THR A 1 160 ? 182.468 185.435 110.069 1.00 71.80  ? 153 THR B N   1 
ATOM   942  C  CA  . THR A 1 160 ? 183.154 185.334 108.788 1.00 65.18  ? 153 THR B CA  1 
ATOM   943  C  C   . THR A 1 160 ? 183.940 184.035 108.675 1.00 66.46  ? 153 THR B C   1 
ATOM   944  O  O   . THR A 1 160 ? 184.029 183.457 107.590 1.00 68.92  ? 153 THR B O   1 
ATOM   945  C  CB  . THR A 1 160 ? 184.074 186.531 108.590 1.00 65.17  ? 153 THR B CB  1 
ATOM   946  O  OG1 . THR A 1 160 ? 184.936 186.658 109.725 1.00 71.79  ? 153 THR B OG1 1 
ATOM   947  C  CG2 . THR A 1 160 ? 183.256 187.796 108.449 1.00 65.27  ? 153 THR B CG2 1 
ATOM   948  N  N   . GLY A 1 161 ? 184.533 183.566 109.773 1.00 68.73  ? 154 GLY B N   1 
ATOM   949  C  CA  . GLY A 1 161 ? 185.263 182.313 109.729 1.00 65.46  ? 154 GLY B CA  1 
ATOM   950  C  C   . GLY A 1 161 ? 184.360 181.122 109.495 1.00 68.43  ? 154 GLY B C   1 
ATOM   951  O  O   . GLY A 1 161 ? 184.689 180.230 108.710 1.00 72.88  ? 154 GLY B O   1 
ATOM   952  N  N   . LYS A 1 162 ? 183.210 181.087 110.170 1.00 70.42  ? 155 LYS B N   1 
ATOM   953  C  CA  . LYS A 1 162 ? 182.252 180.017 109.922 1.00 72.42  ? 155 LYS B CA  1 
ATOM   954  C  C   . LYS A 1 162 ? 181.728 180.067 108.496 1.00 74.81  ? 155 LYS B C   1 
ATOM   955  O  O   . LYS A 1 162 ? 181.383 179.026 107.928 1.00 73.06  ? 155 LYS B O   1 
ATOM   956  C  CB  . LYS A 1 162 ? 181.093 180.101 110.913 1.00 74.44  ? 155 LYS B CB  1 
ATOM   957  C  CG  . LYS A 1 162 ? 181.284 179.276 112.171 1.00 82.75  ? 155 LYS B CG  1 
ATOM   958  C  CD  . LYS A 1 162 ? 180.388 178.050 112.172 1.00 92.73  ? 155 LYS B CD  1 
ATOM   959  C  CE  . LYS A 1 162 ? 180.180 177.525 113.582 1.00 91.11  ? 155 LYS B CE  1 
ATOM   960  N  NZ  . LYS A 1 162 ? 179.108 176.495 113.640 1.00 91.05  ? 155 LYS B NZ  1 
ATOM   961  N  N   . PHE A 1 163 ? 181.646 181.261 107.905 1.00 76.08  ? 156 PHE B N   1 
ATOM   962  C  CA  . PHE A 1 163 ? 181.227 181.341 106.508 1.00 69.31  ? 156 PHE B CA  1 
ATOM   963  C  C   . PHE A 1 163 ? 182.322 180.860 105.562 1.00 67.97  ? 156 PHE B C   1 
ATOM   964  O  O   . PHE A 1 163 ? 182.051 180.098 104.628 1.00 70.78  ? 156 PHE B O   1 
ATOM   965  C  CB  . PHE A 1 163 ? 180.819 182.765 106.154 1.00 67.24  ? 156 PHE B CB  1 
ATOM   966  C  CG  . PHE A 1 163 ? 180.403 182.927 104.729 1.00 67.98  ? 156 PHE B CG  1 
ATOM   967  C  CD1 . PHE A 1 163 ? 179.439 182.104 104.184 1.00 71.48  ? 156 PHE B CD1 1 
ATOM   968  C  CD2 . PHE A 1 163 ? 180.984 183.887 103.928 1.00 71.66  ? 156 PHE B CD2 1 
ATOM   969  C  CE1 . PHE A 1 163 ? 179.053 182.243 102.871 1.00 72.75  ? 156 PHE B CE1 1 
ATOM   970  C  CE2 . PHE A 1 163 ? 180.603 184.028 102.614 1.00 73.26  ? 156 PHE B CE2 1 
ATOM   971  C  CZ  . PHE A 1 163 ? 179.637 183.205 102.085 1.00 72.65  ? 156 PHE B CZ  1 
ATOM   972  N  N   . PHE A 1 164 ? 183.563 181.293 105.783 1.00 68.31  ? 157 PHE B N   1 
ATOM   973  C  CA  . PHE A 1 164 ? 184.651 180.968 104.869 1.00 64.60  ? 157 PHE B CA  1 
ATOM   974  C  C   . PHE A 1 164 ? 185.105 179.524 104.983 1.00 67.68  ? 157 PHE B C   1 
ATOM   975  O  O   . PHE A 1 164 ? 185.649 178.986 104.016 1.00 70.14  ? 157 PHE B O   1 
ATOM   976  C  CB  . PHE A 1 164 ? 185.849 181.880 105.116 1.00 62.16  ? 157 PHE B CB  1 
ATOM   977  C  CG  . PHE A 1 164 ? 185.615 183.304 104.735 1.00 63.18  ? 157 PHE B CG  1 
ATOM   978  C  CD1 . PHE A 1 164 ? 184.743 183.627 103.717 1.00 67.44  ? 157 PHE B CD1 1 
ATOM   979  C  CD2 . PHE A 1 164 ? 186.275 184.321 105.391 1.00 60.60  ? 157 PHE B CD2 1 
ATOM   980  C  CE1 . PHE A 1 164 ? 184.531 184.938 103.364 1.00 65.71  ? 157 PHE B CE1 1 
ATOM   981  C  CE2 . PHE A 1 164 ? 186.065 185.631 105.041 1.00 61.73  ? 157 PHE B CE2 1 
ATOM   982  C  CZ  . PHE A 1 164 ? 185.192 185.940 104.027 1.00 64.07  ? 157 PHE B CZ  1 
ATOM   983  N  N   . SER A 1 165 ? 184.907 178.887 106.138 1.00 67.27  ? 158 SER B N   1 
ATOM   984  C  CA  . SER A 1 165 ? 185.404 177.531 106.321 1.00 67.48  ? 158 SER B CA  1 
ATOM   985  C  C   . SER A 1 165 ? 184.754 176.553 105.356 1.00 70.50  ? 158 SER B C   1 
ATOM   986  O  O   . SER A 1 165 ? 185.344 175.517 105.034 1.00 71.32  ? 158 SER B O   1 
ATOM   987  C  CB  . SER A 1 165 ? 185.171 177.092 107.759 1.00 65.97  ? 158 SER B CB  1 
ATOM   988  O  OG  . SER A 1 165 ? 186.080 177.745 108.624 1.00 70.35  ? 158 SER B OG  1 
ATOM   989  N  N   . PHE A 1 166 ? 183.544 176.855 104.891 1.00 70.17  ? 159 PHE B N   1 
ATOM   990  C  CA  . PHE A 1 166 ? 182.901 175.985 103.914 1.00 71.39  ? 159 PHE B CA  1 
ATOM   991  C  C   . PHE A 1 166 ? 183.655 175.991 102.590 1.00 75.15  ? 159 PHE B C   1 
ATOM   992  O  O   . PHE A 1 166 ? 183.743 174.958 101.918 1.00 80.71  ? 159 PHE B O   1 
ATOM   993  C  CB  . PHE A 1 166 ? 181.450 176.407 103.714 1.00 70.55  ? 159 PHE B CB  1 
ATOM   994  C  CG  . PHE A 1 166 ? 180.792 175.762 102.538 1.00 72.49  ? 159 PHE B CG  1 
ATOM   995  C  CD1 . PHE A 1 166 ? 180.684 174.390 102.460 1.00 75.85  ? 159 PHE B CD1 1 
ATOM   996  C  CD2 . PHE A 1 166 ? 180.281 176.528 101.510 1.00 73.99  ? 159 PHE B CD2 1 
ATOM   997  C  CE1 . PHE A 1 166 ? 180.078 173.796 101.379 1.00 85.55  ? 159 PHE B CE1 1 
ATOM   998  C  CE2 . PHE A 1 166 ? 179.674 175.937 100.427 1.00 78.26  ? 159 PHE B CE2 1 
ATOM   999  C  CZ  . PHE A 1 166 ? 179.574 174.571 100.361 1.00 85.18  ? 159 PHE B CZ  1 
ATOM   1000 N  N   . PHE A 1 167 ? 184.198 177.140 102.197 1.00 74.68  ? 160 PHE B N   1 
ATOM   1001 C  CA  . PHE A 1 167 ? 184.981 177.256 100.974 1.00 75.77  ? 160 PHE B CA  1 
ATOM   1002 C  C   . PHE A 1 167 ? 186.477 177.101 101.200 1.00 74.43  ? 160 PHE B C   1 
ATOM   1003 O  O   . PHE A 1 167 ? 187.242 177.213 100.239 1.00 73.90  ? 160 PHE B O   1 
ATOM   1004 C  CB  . PHE A 1 167 ? 184.727 178.602 100.298 1.00 70.93  ? 160 PHE B CB  1 
ATOM   1005 C  CG  . PHE A 1 167 ? 183.295 179.030 100.310 1.00 72.99  ? 160 PHE B CG  1 
ATOM   1006 C  CD1 . PHE A 1 167 ? 182.801 179.801 101.340 1.00 77.19  ? 160 PHE B CD1 1 
ATOM   1007 C  CD2 . PHE A 1 167 ? 182.448 178.682 99.278  1.00 76.58  ? 160 PHE B CD2 1 
ATOM   1008 C  CE1 . PHE A 1 167 ? 181.486 180.203 101.348 1.00 78.52  ? 160 PHE B CE1 1 
ATOM   1009 C  CE2 . PHE A 1 167 ? 181.133 179.082 99.284  1.00 79.34  ? 160 PHE B CE2 1 
ATOM   1010 C  CZ  . PHE A 1 167 ? 180.653 179.844 100.320 1.00 78.29  ? 160 PHE B CZ  1 
ATOM   1011 N  N   . LEU A 1 168 ? 186.909 176.871 102.439 1.00 74.08  ? 161 LEU B N   1 
ATOM   1012 C  CA  . LEU A 1 168 ? 188.325 176.709 102.764 1.00 74.16  ? 161 LEU B CA  1 
ATOM   1013 C  C   . LEU A 1 168 ? 189.144 177.918 102.317 1.00 73.80  ? 161 LEU B C   1 
ATOM   1014 O  O   . LEU A 1 168 ? 190.276 177.785 101.851 1.00 80.17  ? 161 LEU B O   1 
ATOM   1015 C  CB  . LEU A 1 168 ? 188.888 175.420 102.162 1.00 78.06  ? 161 LEU B CB  1 
ATOM   1016 C  CG  . LEU A 1 168 ? 188.566 174.094 102.849 1.00 79.42  ? 161 LEU B CG  1 
ATOM   1017 C  CD1 . LEU A 1 168 ? 189.641 173.078 102.529 1.00 91.13  ? 161 LEU B CD1 1 
ATOM   1018 C  CD2 . LEU A 1 168 ? 188.432 174.265 104.346 1.00 74.16  ? 161 LEU B CD2 1 
ATOM   1019 N  N   . MET A 1 169 ? 188.571 179.106 102.453 1.00 66.62  ? 162 MET B N   1 
ATOM   1020 C  CA  . MET A 1 169 ? 189.294 180.331 102.131 1.00 66.80  ? 162 MET B CA  1 
ATOM   1021 C  C   . MET A 1 169 ? 190.269 180.682 103.244 1.00 68.68  ? 162 MET B C   1 
ATOM   1022 O  O   . MET A 1 169 ? 189.845 180.859 104.390 1.00 69.95  ? 162 MET B O   1 
ATOM   1023 C  CB  . MET A 1 169 ? 188.335 181.486 101.923 1.00 64.57  ? 162 MET B CB  1 
ATOM   1024 C  CG  . MET A 1 169 ? 189.037 182.772 101.566 1.00 62.13  ? 162 MET B CG  1 
ATOM   1025 S  SD  . MET A 1 169 ? 188.085 183.761 100.421 1.00 75.39  ? 162 MET B SD  1 
ATOM   1026 C  CE  . MET A 1 169 ? 188.305 182.775 98.956  1.00 73.66  ? 162 MET B CE  1 
ATOM   1027 N  N   . PRO A 1 170 ? 191.556 180.818 102.957 1.00 67.73  ? 163 PRO B N   1 
ATOM   1028 C  CA  . PRO A 1 170 ? 192.506 181.182 104.011 1.00 65.71  ? 163 PRO B CA  1 
ATOM   1029 C  C   . PRO A 1 170 ? 192.302 182.604 104.493 1.00 64.04  ? 163 PRO B C   1 
ATOM   1030 O  O   . PRO A 1 170 ? 192.610 183.557 103.775 1.00 66.67  ? 163 PRO B O   1 
ATOM   1031 C  CB  . PRO A 1 170 ? 193.865 181.009 103.328 1.00 64.32  ? 163 PRO B CB  1 
ATOM   1032 C  CG  . PRO A 1 170 ? 193.586 181.171 101.886 1.00 64.05  ? 163 PRO B CG  1 
ATOM   1033 C  CD  . PRO A 1 170 ? 192.216 180.621 101.659 1.00 66.57  ? 163 PRO B CD  1 
ATOM   1034 N  N   . GLN A 1 171 ? 191.785 182.763 105.707 1.00 59.44  ? 164 GLN B N   1 
ATOM   1035 C  CA  . GLN A 1 171 ? 191.526 184.075 106.281 1.00 52.94  ? 164 GLN B CA  1 
ATOM   1036 C  C   . GLN A 1 171 ? 192.391 184.250 107.516 1.00 57.40  ? 164 GLN B C   1 
ATOM   1037 O  O   . GLN A 1 171 ? 192.287 183.464 108.460 1.00 63.21  ? 164 GLN B O   1 
ATOM   1038 C  CB  . GLN A 1 171 ? 190.051 184.236 106.644 1.00 53.34  ? 164 GLN B CB  1 
ATOM   1039 C  CG  . GLN A 1 171 ? 189.800 185.300 107.687 1.00 55.67  ? 164 GLN B CG  1 
ATOM   1040 C  CD  . GLN A 1 171 ? 188.472 185.133 108.377 1.00 61.14  ? 164 GLN B CD  1 
ATOM   1041 O  OE1 . GLN A 1 171 ? 187.908 184.044 108.405 1.00 65.03  ? 164 GLN B OE1 1 
ATOM   1042 N  NE2 . GLN A 1 171 ? 187.964 186.215 108.947 1.00 61.52  ? 164 GLN B NE2 1 
ATOM   1043 N  N   . VAL A 1 172 ? 193.235 185.274 107.513 1.00 54.53  ? 165 VAL B N   1 
ATOM   1044 C  CA  . VAL A 1 172 ? 194.061 185.611 108.664 1.00 54.55  ? 165 VAL B CA  1 
ATOM   1045 C  C   . VAL A 1 172 ? 193.511 186.886 109.279 1.00 53.42  ? 165 VAL B C   1 
ATOM   1046 O  O   . VAL A 1 172 ? 193.159 187.829 108.566 1.00 56.72  ? 165 VAL B O   1 
ATOM   1047 C  CB  . VAL A 1 172 ? 195.550 185.749 108.290 1.00 55.00  ? 165 VAL B CB  1 
ATOM   1048 C  CG1 . VAL A 1 172 ? 195.965 184.604 107.406 1.00 62.58  ? 165 VAL B CG1 1 
ATOM   1049 C  CG2 . VAL A 1 172 ? 195.819 187.038 107.577 1.00 53.38  ? 165 VAL B CG2 1 
ATOM   1050 N  N   . SER A 1 173 ? 193.399 186.900 110.599 1.00 57.25  ? 166 SER B N   1 
ATOM   1051 C  CA  . SER A 1 173 ? 192.738 187.985 111.301 1.00 57.77  ? 166 SER B CA  1 
ATOM   1052 C  C   . SER A 1 173 ? 193.708 188.682 112.238 1.00 63.12  ? 166 SER B C   1 
ATOM   1053 O  O   . SER A 1 173 ? 194.649 188.076 112.751 1.00 71.41  ? 166 SER B O   1 
ATOM   1054 C  CB  . SER A 1 173 ? 191.544 187.480 112.099 1.00 60.77  ? 166 SER B CB  1 
ATOM   1055 O  OG  . SER A 1 173 ? 191.239 188.376 113.148 1.00 63.21  ? 166 SER B OG  1 
ATOM   1056 N  N   . TYR A 1 174 ? 193.466 189.966 112.455 1.00 61.92  ? 167 TYR B N   1 
ATOM   1057 C  CA  . TYR A 1 174 ? 194.211 190.766 113.410 1.00 63.62  ? 167 TYR B CA  1 
ATOM   1058 C  C   . TYR A 1 174 ? 193.274 191.175 114.537 1.00 70.42  ? 167 TYR B C   1 
ATOM   1059 O  O   . TYR A 1 174 ? 192.124 191.549 114.294 1.00 74.05  ? 167 TYR B O   1 
ATOM   1060 C  CB  . TYR A 1 174 ? 194.809 192.003 112.738 1.00 58.63  ? 167 TYR B CB  1 
ATOM   1061 C  CG  . TYR A 1 174 ? 193.786 192.812 111.981 1.00 59.15  ? 167 TYR B CG  1 
ATOM   1062 C  CD1 . TYR A 1 174 ? 193.464 192.510 110.670 1.00 56.34  ? 167 TYR B CD1 1 
ATOM   1063 C  CD2 . TYR A 1 174 ? 193.132 193.871 112.583 1.00 65.38  ? 167 TYR B CD2 1 
ATOM   1064 C  CE1 . TYR A 1 174 ? 192.525 193.239 109.985 1.00 56.60  ? 167 TYR B CE1 1 
ATOM   1065 C  CE2 . TYR A 1 174 ? 192.191 194.603 111.906 1.00 62.79  ? 167 TYR B CE2 1 
ATOM   1066 C  CZ  . TYR A 1 174 ? 191.891 194.284 110.609 1.00 58.81  ? 167 TYR B CZ  1 
ATOM   1067 O  OH  . TYR A 1 174 ? 190.951 195.019 109.932 1.00 61.59  ? 167 TYR B OH  1 
ATOM   1068 N  N   . GLY A 1 175 ? 193.747 191.064 115.772 1.00 70.48  ? 168 GLY B N   1 
ATOM   1069 C  CA  . GLY A 1 175 ? 192.976 191.507 116.911 1.00 74.32  ? 168 GLY B CA  1 
ATOM   1070 C  C   . GLY A 1 175 ? 191.917 190.546 117.405 1.00 78.12  ? 168 GLY B C   1 
ATOM   1071 O  O   . GLY A 1 175 ? 191.348 190.784 118.477 1.00 82.84  ? 168 GLY B O   1 
ATOM   1072 N  N   . ALA A 1 176 ? 191.628 189.472 116.676 1.00 73.83  ? 169 ALA B N   1 
ATOM   1073 C  CA  . ALA A 1 176 ? 190.675 188.476 117.150 1.00 73.70  ? 169 ALA B CA  1 
ATOM   1074 C  C   . ALA A 1 176 ? 191.388 187.527 118.100 1.00 75.15  ? 169 ALA B C   1 
ATOM   1075 O  O   . ALA A 1 176 ? 192.336 186.842 117.705 1.00 72.79  ? 169 ALA B O   1 
ATOM   1076 C  CB  . ALA A 1 176 ? 190.060 187.711 115.983 1.00 73.22  ? 169 ALA B CB  1 
ATOM   1077 N  N   . SER A 1 177 ? 190.931 187.478 119.349 1.00 75.63  ? 170 SER B N   1 
ATOM   1078 C  CA  . SER A 1 177 ? 191.656 186.774 120.390 1.00 76.16  ? 170 SER B CA  1 
ATOM   1079 C  C   . SER A 1 177 ? 190.852 185.718 121.129 1.00 80.24  ? 170 SER B C   1 
ATOM   1080 O  O   . SER A 1 177 ? 191.453 184.916 121.848 1.00 86.04  ? 170 SER B O   1 
ATOM   1081 C  CB  . SER A 1 177 ? 192.205 187.772 121.420 1.00 75.58  ? 170 SER B CB  1 
ATOM   1082 O  OG  . SER A 1 177 ? 191.238 188.041 122.417 1.00 74.24  ? 170 SER B OG  1 
ATOM   1083 N  N   . MET A 1 178 ? 189.530 185.688 120.996 1.00 81.22  ? 171 MET B N   1 
ATOM   1084 C  CA  . MET A 1 178 ? 188.758 184.726 121.769 1.00 85.18  ? 171 MET B CA  1 
ATOM   1085 C  C   . MET A 1 178 ? 189.053 183.301 121.312 1.00 85.16  ? 171 MET B C   1 
ATOM   1086 O  O   . MET A 1 178 ? 189.311 183.038 120.136 1.00 83.27  ? 171 MET B O   1 
ATOM   1087 C  CB  . MET A 1 178 ? 187.267 185.047 121.699 1.00 85.42  ? 171 MET B CB  1 
ATOM   1088 C  CG  . MET A 1 178 ? 186.991 186.532 121.872 1.00 89.80  ? 171 MET B CG  1 
ATOM   1089 S  SD  . MET A 1 178 ? 185.329 186.944 122.428 1.00 99.13  ? 171 MET B SD  1 
ATOM   1090 C  CE  . MET A 1 178 ? 184.416 185.530 121.842 1.00 90.17  ? 171 MET B CE  1 
ATOM   1091 N  N   . GLU A 1 179 ? 189.016 182.379 122.275 1.00 85.08  ? 172 GLU B N   1 
ATOM   1092 C  CA  . GLU A 1 179 ? 189.766 181.135 122.148 1.00 87.87  ? 172 GLU B CA  1 
ATOM   1093 C  C   . GLU A 1 179 ? 189.136 180.168 121.156 1.00 87.04  ? 172 GLU B C   1 
ATOM   1094 O  O   . GLU A 1 179 ? 189.854 179.487 120.416 1.00 87.51  ? 172 GLU B O   1 
ATOM   1095 C  CB  . GLU A 1 179 ? 189.910 180.473 123.517 1.00 92.23  ? 172 GLU B CB  1 
ATOM   1096 C  CG  . GLU A 1 179 ? 190.431 179.043 123.475 1.00 96.50  ? 172 GLU B CG  1 
ATOM   1097 C  CD  . GLU A 1 179 ? 191.800 178.922 122.830 1.00 95.66  ? 172 GLU B CD  1 
ATOM   1098 O  OE1 . GLU A 1 179 ? 192.527 179.933 122.751 1.00 92.61  ? 172 GLU B OE1 1 
ATOM   1099 O  OE2 . GLU A 1 179 ? 192.153 177.806 122.401 1.00 99.50  ? 172 GLU B OE2 1 
ATOM   1100 N  N   . LEU A 1 180 ? 187.808 180.077 121.124 1.00 83.94  ? 173 LEU B N   1 
ATOM   1101 C  CA  . LEU A 1 180 ? 187.203 179.000 120.347 1.00 85.02  ? 173 LEU B CA  1 
ATOM   1102 C  C   . LEU A 1 180 ? 187.414 179.151 118.847 1.00 84.57  ? 173 LEU B C   1 
ATOM   1103 O  O   . LEU A 1 180 ? 187.021 178.252 118.097 1.00 85.36  ? 173 LEU B O   1 
ATOM   1104 C  CB  . LEU A 1 180 ? 185.711 178.884 120.660 1.00 86.55  ? 173 LEU B CB  1 
ATOM   1105 C  CG  . LEU A 1 180 ? 184.713 179.888 120.096 1.00 84.99  ? 173 LEU B CG  1 
ATOM   1106 C  CD1 . LEU A 1 180 ? 184.072 179.362 118.826 1.00 82.29  ? 173 LEU B CD1 1 
ATOM   1107 C  CD2 . LEU A 1 180 ? 183.653 180.153 121.134 1.00 82.80  ? 173 LEU B CD2 1 
ATOM   1108 N  N   . LEU A 1 181 ? 188.019 180.247 118.391 1.00 83.17  ? 174 LEU B N   1 
ATOM   1109 C  CA  . LEU A 1 181 ? 188.414 180.369 116.995 1.00 80.65  ? 174 LEU B CA  1 
ATOM   1110 C  C   . LEU A 1 181 ? 189.556 179.435 116.622 1.00 83.26  ? 174 LEU B C   1 
ATOM   1111 O  O   . LEU A 1 181 ? 189.853 179.293 115.433 1.00 84.20  ? 174 LEU B O   1 
ATOM   1112 C  CB  . LEU A 1 181 ? 188.811 181.809 116.689 1.00 74.03  ? 174 LEU B CB  1 
ATOM   1113 C  CG  . LEU A 1 181 ? 187.629 182.754 116.528 1.00 75.04  ? 174 LEU B CG  1 
ATOM   1114 C  CD1 . LEU A 1 181 ? 188.106 184.186 116.475 1.00 77.13  ? 174 LEU B CD1 1 
ATOM   1115 C  CD2 . LEU A 1 181 ? 186.857 182.393 115.283 1.00 76.37  ? 174 LEU B CD2 1 
ATOM   1116 N  N   . SER A 1 182 ? 190.212 178.817 117.598 1.00 84.26  ? 175 SER B N   1 
ATOM   1117 C  CA  . SER A 1 182 ? 191.298 177.886 117.338 1.00 82.27  ? 175 SER B CA  1 
ATOM   1118 C  C   . SER A 1 182 ? 190.814 176.460 117.125 1.00 83.92  ? 175 SER B C   1 
ATOM   1119 O  O   . SER A 1 182 ? 191.635 175.574 116.874 1.00 86.16  ? 175 SER B O   1 
ATOM   1120 C  CB  . SER A 1 182 ? 192.306 177.918 118.488 1.00 84.72  ? 175 SER B CB  1 
ATOM   1121 O  OG  . SER A 1 182 ? 193.523 177.303 118.113 1.00 85.98  ? 175 SER B OG  1 
ATOM   1122 N  N   . ALA A 1 183 ? 189.511 176.217 117.216 1.00 80.47  ? 176 ALA B N   1 
ATOM   1123 C  CA  . ALA A 1 183 ? 188.973 174.876 117.024 1.00 78.87  ? 176 ALA B CA  1 
ATOM   1124 C  C   . ALA A 1 183 ? 189.041 174.510 115.549 1.00 81.50  ? 176 ALA B C   1 
ATOM   1125 O  O   . ALA A 1 183 ? 188.227 174.978 114.749 1.00 81.24  ? 176 ALA B O   1 
ATOM   1126 C  CB  . ALA A 1 183 ? 187.539 174.807 117.537 1.00 73.39  ? 176 ALA B CB  1 
ATOM   1127 N  N   . ARG A 1 184 ? 190.003 173.661 115.187 1.00 82.91  ? 177 ARG B N   1 
ATOM   1128 C  CA  . ARG A 1 184 ? 190.173 173.261 113.796 1.00 77.92  ? 177 ARG B CA  1 
ATOM   1129 C  C   . ARG A 1 184 ? 189.044 172.377 113.289 1.00 74.53  ? 177 ARG B C   1 
ATOM   1130 O  O   . ARG A 1 184 ? 188.984 172.110 112.086 1.00 70.99  ? 177 ARG B O   1 
ATOM   1131 C  CB  . ARG A 1 184 ? 191.508 172.545 113.616 1.00 78.17  ? 177 ARG B CB  1 
ATOM   1132 C  CG  . ARG A 1 184 ? 192.710 173.363 114.046 1.00 78.93  ? 177 ARG B CG  1 
ATOM   1133 C  CD  . ARG A 1 184 ? 192.937 174.541 113.119 1.00 78.95  ? 177 ARG B CD  1 
ATOM   1134 N  NE  . ARG A 1 184 ? 192.264 175.746 113.585 1.00 80.20  ? 177 ARG B NE  1 
ATOM   1135 C  CZ  . ARG A 1 184 ? 192.432 176.948 113.056 1.00 80.97  ? 177 ARG B CZ  1 
ATOM   1136 N  NH1 . ARG A 1 184 ? 193.248 177.144 112.036 1.00 80.99  ? 177 ARG B NH1 1 
ATOM   1137 N  NH2 . ARG A 1 184 ? 191.768 177.980 113.567 1.00 77.85  ? 177 ARG B NH2 1 
ATOM   1138 N  N   . GLU A 1 185 ? 188.167 171.897 114.169 1.00 76.68  ? 178 GLU B N   1 
ATOM   1139 C  CA  . GLU A 1 185 ? 187.003 171.153 113.707 1.00 80.87  ? 178 GLU B CA  1 
ATOM   1140 C  C   . GLU A 1 185 ? 186.041 172.053 112.943 1.00 82.23  ? 178 GLU B C   1 
ATOM   1141 O  O   . GLU A 1 185 ? 185.501 171.653 111.905 1.00 86.17  ? 178 GLU B O   1 
ATOM   1142 C  CB  . GLU A 1 185 ? 186.297 170.493 114.890 1.00 88.01  ? 178 GLU B CB  1 
ATOM   1143 C  CG  . GLU A 1 185 ? 184.873 170.057 114.598 1.00 96.35  ? 178 GLU B CG  1 
ATOM   1144 C  CD  . GLU A 1 185 ? 184.356 169.040 115.594 1.00 107.48 ? 178 GLU B CD  1 
ATOM   1145 O  OE1 . GLU A 1 185 ? 184.813 167.878 115.550 1.00 103.82 ? 178 GLU B OE1 1 
ATOM   1146 O  OE2 . GLU A 1 185 ? 183.493 169.401 116.420 1.00 120.08 ? 178 GLU B OE2 1 
ATOM   1147 N  N   . THR A 1 186 ? 185.817 173.273 113.432 1.00 81.97  ? 179 THR B N   1 
ATOM   1148 C  CA  . THR A 1 186 ? 184.835 174.170 112.840 1.00 80.11  ? 179 THR B CA  1 
ATOM   1149 C  C   . THR A 1 186 ? 185.433 175.418 112.207 1.00 77.52  ? 179 THR B C   1 
ATOM   1150 O  O   . THR A 1 186 ? 184.685 176.200 111.614 1.00 78.56  ? 179 THR B O   1 
ATOM   1151 C  CB  . THR A 1 186 ? 183.800 174.601 113.888 1.00 84.15  ? 179 THR B CB  1 
ATOM   1152 O  OG1 . THR A 1 186 ? 184.343 175.653 114.692 1.00 83.05  ? 179 THR B OG1 1 
ATOM   1153 C  CG2 . THR A 1 186 ? 183.421 173.433 114.782 1.00 85.95  ? 179 THR B CG2 1 
ATOM   1154 N  N   . PHE A 1 187 ? 186.741 175.638 112.320 1.00 76.35  ? 180 PHE B N   1 
ATOM   1155 C  CA  . PHE A 1 187 ? 187.421 176.748 111.651 1.00 69.13  ? 180 PHE B CA  1 
ATOM   1156 C  C   . PHE A 1 187 ? 188.668 176.228 110.950 1.00 70.53  ? 180 PHE B C   1 
ATOM   1157 O  O   . PHE A 1 187 ? 189.794 176.567 111.331 1.00 71.97  ? 180 PHE B O   1 
ATOM   1158 C  CB  . PHE A 1 187 ? 187.790 177.846 112.646 1.00 68.94  ? 180 PHE B CB  1 
ATOM   1159 C  CG  . PHE A 1 187 ? 186.613 178.533 113.254 1.00 73.37  ? 180 PHE B CG  1 
ATOM   1160 C  CD1 . PHE A 1 187 ? 186.007 179.593 112.615 1.00 75.43  ? 180 PHE B CD1 1 
ATOM   1161 C  CD2 . PHE A 1 187 ? 186.116 178.123 114.471 1.00 77.08  ? 180 PHE B CD2 1 
ATOM   1162 C  CE1 . PHE A 1 187 ? 184.925 180.228 113.180 1.00 76.59  ? 180 PHE B CE1 1 
ATOM   1163 C  CE2 . PHE A 1 187 ? 185.036 178.752 115.039 1.00 79.04  ? 180 PHE B CE2 1 
ATOM   1164 C  CZ  . PHE A 1 187 ? 184.440 179.806 114.394 1.00 80.49  ? 180 PHE B CZ  1 
ATOM   1165 N  N   . PRO A 1 188 ? 188.507 175.405 109.910 1.00 71.01  ? 181 PRO B N   1 
ATOM   1166 C  CA  . PRO A 1 188 ? 189.684 174.819 109.253 1.00 72.31  ? 181 PRO B CA  1 
ATOM   1167 C  C   . PRO A 1 188 ? 190.536 175.820 108.499 1.00 75.24  ? 181 PRO B C   1 
ATOM   1168 O  O   . PRO A 1 188 ? 191.642 175.460 108.082 1.00 79.81  ? 181 PRO B O   1 
ATOM   1169 C  CB  . PRO A 1 188 ? 189.075 173.788 108.294 1.00 71.48  ? 181 PRO B CB  1 
ATOM   1170 C  CG  . PRO A 1 188 ? 187.687 173.574 108.778 1.00 71.00  ? 181 PRO B CG  1 
ATOM   1171 C  CD  . PRO A 1 188 ? 187.260 174.878 109.342 1.00 71.79  ? 181 PRO B CD  1 
ATOM   1172 N  N   . SER A 1 189 ? 190.070 177.052 108.301 1.00 74.13  ? 182 SER B N   1 
ATOM   1173 C  CA  . SER A 1 189 ? 190.786 178.016 107.476 1.00 71.34  ? 182 SER B CA  1 
ATOM   1174 C  C   . SER A 1 189 ? 190.816 179.397 108.114 1.00 70.87  ? 182 SER B C   1 
ATOM   1175 O  O   . SER A 1 189 ? 190.750 180.407 107.412 1.00 72.07  ? 182 SER B O   1 
ATOM   1176 C  CB  . SER A 1 189 ? 190.166 178.097 106.085 1.00 71.56  ? 182 SER B CB  1 
ATOM   1177 O  OG  . SER A 1 189 ? 188.904 178.736 106.145 1.00 71.98  ? 182 SER B OG  1 
ATOM   1178 N  N   . PHE A 1 190 ? 190.917 179.465 109.437 1.00 71.04  ? 183 PHE B N   1 
ATOM   1179 C  CA  . PHE A 1 190 ? 191.000 180.732 110.151 1.00 66.68  ? 183 PHE B CA  1 
ATOM   1180 C  C   . PHE A 1 190 ? 192.331 180.802 110.875 1.00 65.99  ? 183 PHE B C   1 
ATOM   1181 O  O   . PHE A 1 190 ? 192.595 179.997 111.773 1.00 70.09  ? 183 PHE B O   1 
ATOM   1182 C  CB  . PHE A 1 190 ? 189.851 180.895 111.145 1.00 65.55  ? 183 PHE B CB  1 
ATOM   1183 C  CG  . PHE A 1 190 ? 189.903 182.176 111.920 1.00 66.13  ? 183 PHE B CG  1 
ATOM   1184 C  CD1 . PHE A 1 190 ? 189.384 183.341 111.394 1.00 67.27  ? 183 PHE B CD1 1 
ATOM   1185 C  CD2 . PHE A 1 190 ? 190.478 182.218 113.174 1.00 67.87  ? 183 PHE B CD2 1 
ATOM   1186 C  CE1 . PHE A 1 190 ? 189.435 184.522 112.107 1.00 67.39  ? 183 PHE B CE1 1 
ATOM   1187 C  CE2 . PHE A 1 190 ? 190.530 183.396 113.887 1.00 68.20  ? 183 PHE B CE2 1 
ATOM   1188 C  CZ  . PHE A 1 190 ? 190.010 184.547 113.353 1.00 64.35  ? 183 PHE B CZ  1 
ATOM   1189 N  N   . PHE A 1 191 ? 193.155 181.761 110.494 1.00 61.56  ? 184 PHE B N   1 
ATOM   1190 C  CA  . PHE A 1 191 ? 194.411 182.048 111.160 1.00 62.26  ? 184 PHE B CA  1 
ATOM   1191 C  C   . PHE A 1 191 ? 194.306 183.398 111.853 1.00 63.93  ? 184 PHE B C   1 
ATOM   1192 O  O   . PHE A 1 191 ? 193.288 184.087 111.770 1.00 67.82  ? 184 PHE B O   1 
ATOM   1193 C  CB  . PHE A 1 191 ? 195.566 182.024 110.162 1.00 63.44  ? 184 PHE B CB  1 
ATOM   1194 C  CG  . PHE A 1 191 ? 195.786 180.688 109.530 1.00 70.15  ? 184 PHE B CG  1 
ATOM   1195 C  CD1 . PHE A 1 191 ? 195.046 180.298 108.431 1.00 68.28  ? 184 PHE B CD1 1 
ATOM   1196 C  CD2 . PHE A 1 191 ? 196.731 179.819 110.034 1.00 75.86  ? 184 PHE B CD2 1 
ATOM   1197 C  CE1 . PHE A 1 191 ? 195.247 179.069 107.850 1.00 72.76  ? 184 PHE B CE1 1 
ATOM   1198 C  CE2 . PHE A 1 191 ? 196.935 178.589 109.455 1.00 78.64  ? 184 PHE B CE2 1 
ATOM   1199 C  CZ  . PHE A 1 191 ? 196.191 178.213 108.363 1.00 76.88  ? 184 PHE B CZ  1 
ATOM   1200 N  N   . ARG A 1 192 ? 195.370 183.776 112.550 1.00 63.57  ? 185 ARG B N   1 
ATOM   1201 C  CA  . ARG A 1 192 ? 195.384 185.059 113.232 1.00 60.52  ? 185 ARG B CA  1 
ATOM   1202 C  C   . ARG A 1 192 ? 196.824 185.470 113.472 1.00 64.37  ? 185 ARG B C   1 
ATOM   1203 O  O   . ARG A 1 192 ? 197.750 184.671 113.322 1.00 75.24  ? 185 ARG B O   1 
ATOM   1204 C  CB  . ARG A 1 192 ? 194.608 185.005 114.546 1.00 62.41  ? 185 ARG B CB  1 
ATOM   1205 C  CG  . ARG A 1 192 ? 195.329 184.269 115.643 1.00 73.61  ? 185 ARG B CG  1 
ATOM   1206 C  CD  . ARG A 1 192 ? 194.440 183.216 116.263 1.00 76.80  ? 185 ARG B CD  1 
ATOM   1207 N  NE  . ARG A 1 192 ? 193.388 183.806 117.077 1.00 74.44  ? 185 ARG B NE  1 
ATOM   1208 C  CZ  . ARG A 1 192 ? 192.524 183.107 117.794 1.00 74.95  ? 185 ARG B CZ  1 
ATOM   1209 N  NH1 . ARG A 1 192 ? 192.557 181.787 117.818 1.00 74.75  ? 185 ARG B NH1 1 
ATOM   1210 N  NH2 . ARG A 1 192 ? 191.606 183.748 118.510 1.00 77.22  ? 185 ARG B NH2 1 
ATOM   1211 N  N   . THR A 1 193 ? 197.002 186.736 113.829 1.00 60.01  ? 186 THR B N   1 
ATOM   1212 C  CA  . THR A 1 193 ? 198.318 187.277 114.108 1.00 63.73  ? 186 THR B CA  1 
ATOM   1213 C  C   . THR A 1 193 ? 198.476 187.748 115.547 1.00 70.76  ? 186 THR B C   1 
ATOM   1214 O  O   . THR A 1 193 ? 199.594 188.079 115.954 1.00 74.08  ? 186 THR B O   1 
ATOM   1215 C  CB  . THR A 1 193 ? 198.625 188.432 113.144 1.00 68.69  ? 186 THR B CB  1 
ATOM   1216 O  OG1 . THR A 1 193 ? 198.200 188.064 111.830 1.00 67.00  ? 186 THR B OG1 1 
ATOM   1217 C  CG2 . THR A 1 193 ? 200.114 188.709 113.088 1.00 72.33  ? 186 THR B CG2 1 
ATOM   1218 N  N   . VAL A 1 194 ? 197.404 187.778 116.331 1.00 72.03  ? 187 VAL B N   1 
ATOM   1219 C  CA  . VAL A 1 194 ? 197.496 188.134 117.744 1.00 70.18  ? 187 VAL B CA  1 
ATOM   1220 C  C   . VAL A 1 194 ? 197.365 186.863 118.573 1.00 70.36  ? 187 VAL B C   1 
ATOM   1221 O  O   . VAL A 1 194 ? 196.633 185.945 118.180 1.00 76.63  ? 187 VAL B O   1 
ATOM   1222 C  CB  . VAL A 1 194 ? 196.422 189.157 118.132 1.00 69.05  ? 187 VAL B CB  1 
ATOM   1223 C  CG1 . VAL A 1 194 ? 196.749 190.509 117.533 1.00 71.13  ? 187 VAL B CG1 1 
ATOM   1224 C  CG2 . VAL A 1 194 ? 195.069 188.678 117.668 1.00 71.93  ? 187 VAL B CG2 1 
ATOM   1225 N  N   . PRO A 1 195 ? 198.051 186.756 119.707 1.00 68.18  ? 188 PRO B N   1 
ATOM   1226 C  CA  . PRO A 1 195 ? 197.934 185.542 120.517 1.00 69.07  ? 188 PRO B CA  1 
ATOM   1227 C  C   . PRO A 1 195 ? 196.529 185.383 121.070 1.00 70.09  ? 188 PRO B C   1 
ATOM   1228 O  O   . PRO A 1 195 ? 195.849 186.359 121.389 1.00 72.95  ? 188 PRO B O   1 
ATOM   1229 C  CB  . PRO A 1 195 ? 198.956 185.762 121.637 1.00 72.89  ? 188 PRO B CB  1 
ATOM   1230 C  CG  . PRO A 1 195 ? 199.133 187.233 121.699 1.00 77.72  ? 188 PRO B CG  1 
ATOM   1231 C  CD  . PRO A 1 195 ? 198.973 187.733 120.302 1.00 72.44  ? 188 PRO B CD  1 
ATOM   1232 N  N   . SER A 1 196 ? 196.099 184.131 121.186 1.00 71.36  ? 189 SER B N   1 
ATOM   1233 C  CA  . SER A 1 196 ? 194.759 183.846 121.666 1.00 75.51  ? 189 SER B CA  1 
ATOM   1234 C  C   . SER A 1 196 ? 194.669 184.079 123.171 1.00 79.40  ? 189 SER B C   1 
ATOM   1235 O  O   . SER A 1 196 ? 195.674 184.224 123.870 1.00 82.74  ? 189 SER B O   1 
ATOM   1236 C  CB  . SER A 1 196 ? 194.367 182.411 121.330 1.00 81.18  ? 189 SER B CB  1 
ATOM   1237 O  OG  . SER A 1 196 ? 195.468 181.540 121.498 1.00 85.88  ? 189 SER B OG  1 
ATOM   1238 N  N   . ASP A 1 197 ? 193.432 184.115 123.671 1.00 80.13  ? 190 ASP B N   1 
ATOM   1239 C  CA  . ASP A 1 197 ? 193.207 184.302 125.098 1.00 79.68  ? 190 ASP B CA  1 
ATOM   1240 C  C   . ASP A 1 197 ? 193.788 183.169 125.925 1.00 82.17  ? 190 ASP B C   1 
ATOM   1241 O  O   . ASP A 1 197 ? 194.072 183.363 127.112 1.00 83.51  ? 190 ASP B O   1 
ATOM   1242 C  CB  . ASP A 1 197 ? 191.713 184.426 125.383 1.00 78.95  ? 190 ASP B CB  1 
ATOM   1243 C  CG  . ASP A 1 197 ? 191.191 185.819 125.137 1.00 87.46  ? 190 ASP B CG  1 
ATOM   1244 O  OD1 . ASP A 1 197 ? 192.017 186.748 125.032 1.00 90.80  ? 190 ASP B OD1 1 
ATOM   1245 O  OD2 . ASP A 1 197 ? 189.957 185.988 125.053 1.00 88.97  ? 190 ASP B OD2 1 
ATOM   1246 N  N   . ARG A 1 198 ? 193.968 181.992 125.327 1.00 83.65  ? 191 ARG B N   1 
ATOM   1247 C  CA  . ARG A 1 198 ? 194.537 180.874 126.066 1.00 80.75  ? 191 ARG B CA  1 
ATOM   1248 C  C   . ARG A 1 198 ? 195.950 181.188 126.530 1.00 78.81  ? 191 ARG B C   1 
ATOM   1249 O  O   . ARG A 1 198 ? 196.357 180.758 127.609 1.00 78.28  ? 191 ARG B O   1 
ATOM   1250 C  CB  . ARG A 1 198 ? 194.522 179.610 125.209 1.00 85.82  ? 191 ARG B CB  1 
ATOM   1251 C  CG  . ARG A 1 198 ? 193.713 178.472 125.802 1.00 91.11  ? 191 ARG B CG  1 
ATOM   1252 C  CD  . ARG A 1 198 ? 193.936 177.173 125.047 1.00 101.33 ? 191 ARG B CD  1 
ATOM   1253 N  NE  . ARG A 1 198 ? 195.134 176.465 125.480 1.00 108.60 ? 191 ARG B NE  1 
ATOM   1254 C  CZ  . ARG A 1 198 ? 195.129 175.426 126.304 1.00 105.07 ? 191 ARG B CZ  1 
ATOM   1255 N  NH1 . ARG A 1 198 ? 194.004 174.952 126.812 1.00 102.36 ? 191 ARG B NH1 1 
ATOM   1256 N  NH2 . ARG A 1 198 ? 196.283 174.847 126.624 1.00 95.77  ? 191 ARG B NH2 1 
ATOM   1257 N  N   . VAL A 1 199 ? 196.709 181.951 125.741 1.00 77.68  ? 192 VAL B N   1 
ATOM   1258 C  CA  . VAL A 1 199 ? 198.093 182.242 126.111 1.00 74.92  ? 192 VAL B CA  1 
ATOM   1259 C  C   . VAL A 1 199 ? 198.145 183.112 127.359 1.00 76.07  ? 192 VAL B C   1 
ATOM   1260 O  O   . VAL A 1 199 ? 198.861 182.808 128.320 1.00 81.00  ? 192 VAL B O   1 
ATOM   1261 C  CB  . VAL A 1 199 ? 198.841 182.896 124.940 1.00 73.16  ? 192 VAL B CB  1 
ATOM   1262 C  CG1 . VAL A 1 199 ? 200.190 183.398 125.406 1.00 72.52  ? 192 VAL B CG1 1 
ATOM   1263 C  CG2 . VAL A 1 199 ? 199.009 181.903 123.810 1.00 77.65  ? 192 VAL B CG2 1 
ATOM   1264 N  N   . GLN A 1 200 ? 197.379 184.202 127.375 1.00 72.30  ? 193 GLN B N   1 
ATOM   1265 C  CA  . GLN A 1 200 ? 197.418 185.075 128.542 1.00 72.88  ? 193 GLN B CA  1 
ATOM   1266 C  C   . GLN A 1 200 ? 196.743 184.430 129.745 1.00 73.61  ? 193 GLN B C   1 
ATOM   1267 O  O   . GLN A 1 200 ? 197.165 184.657 130.883 1.00 71.94  ? 193 GLN B O   1 
ATOM   1268 C  CB  . GLN A 1 200 ? 196.794 186.431 128.212 1.00 75.32  ? 193 GLN B CB  1 
ATOM   1269 C  CG  . GLN A 1 200 ? 195.319 186.566 128.494 1.00 77.18  ? 193 GLN B CG  1 
ATOM   1270 C  CD  . GLN A 1 200 ? 194.787 187.924 128.092 1.00 80.13  ? 193 GLN B CD  1 
ATOM   1271 O  OE1 . GLN A 1 200 ? 195.364 188.953 128.436 1.00 82.27  ? 193 GLN B OE1 1 
ATOM   1272 N  NE2 . GLN A 1 200 ? 193.686 187.934 127.354 1.00 80.44  ? 193 GLN B NE2 1 
ATOM   1273 N  N   . LEU A 1 201 ? 195.727 183.595 129.522 1.00 78.60  ? 194 LEU B N   1 
ATOM   1274 C  CA  . LEU A 1 201 ? 195.109 182.893 130.641 1.00 75.15  ? 194 LEU B CA  1 
ATOM   1275 C  C   . LEU A 1 201 ? 196.047 181.844 131.226 1.00 77.58  ? 194 LEU B C   1 
ATOM   1276 O  O   . LEU A 1 201 ? 196.095 181.663 132.445 1.00 80.46  ? 194 LEU B O   1 
ATOM   1277 C  CB  . LEU A 1 201 ? 193.794 182.261 130.202 1.00 72.86  ? 194 LEU B CB  1 
ATOM   1278 C  CG  . LEU A 1 201 ? 192.640 183.256 130.183 1.00 71.78  ? 194 LEU B CG  1 
ATOM   1279 C  CD1 . LEU A 1 201 ? 191.440 182.666 129.482 1.00 78.49  ? 194 LEU B CD1 1 
ATOM   1280 C  CD2 . LEU A 1 201 ? 192.293 183.669 131.594 1.00 76.23  ? 194 LEU B CD2 1 
ATOM   1281 N  N   . THR A 1 202 ? 196.801 181.143 130.378 1.00 75.83  ? 195 THR B N   1 
ATOM   1282 C  CA  . THR A 1 202 ? 197.804 180.211 130.876 1.00 74.78  ? 195 THR B CA  1 
ATOM   1283 C  C   . THR A 1 202 ? 198.908 180.948 131.617 1.00 75.89  ? 195 THR B C   1 
ATOM   1284 O  O   . THR A 1 202 ? 199.406 180.463 132.637 1.00 78.91  ? 195 THR B O   1 
ATOM   1285 C  CB  . THR A 1 202 ? 198.380 179.392 129.723 1.00 72.50  ? 195 THR B CB  1 
ATOM   1286 O  OG1 . THR A 1 202 ? 197.346 178.589 129.146 1.00 76.29  ? 195 THR B OG1 1 
ATOM   1287 C  CG2 . THR A 1 202 ? 199.487 178.485 130.213 1.00 70.28  ? 195 THR B CG2 1 
ATOM   1288 N  N   . ALA A 1 203 ? 199.301 182.123 131.127 1.00 73.42  ? 196 ALA B N   1 
ATOM   1289 C  CA  . ALA A 1 203 ? 200.291 182.914 131.847 1.00 73.72  ? 196 ALA B CA  1 
ATOM   1290 C  C   . ALA A 1 203 ? 199.774 183.326 133.218 1.00 74.91  ? 196 ALA B C   1 
ATOM   1291 O  O   . ALA A 1 203 ? 200.507 183.266 134.210 1.00 74.46  ? 196 ALA B O   1 
ATOM   1292 C  CB  . ALA A 1 203 ? 200.678 184.142 131.028 1.00 75.86  ? 196 ALA B CB  1 
ATOM   1293 N  N   . ALA A 1 204 ? 198.510 183.745 133.297 1.00 75.53  ? 197 ALA B N   1 
ATOM   1294 C  CA  . ALA A 1 204 ? 197.934 184.116 134.586 1.00 70.26  ? 197 ALA B CA  1 
ATOM   1295 C  C   . ALA A 1 204 ? 197.837 182.915 135.519 1.00 72.46  ? 197 ALA B C   1 
ATOM   1296 O  O   . ALA A 1 204 ? 198.097 183.031 136.722 1.00 74.17  ? 197 ALA B O   1 
ATOM   1297 C  CB  . ALA A 1 204 ? 196.560 184.753 134.386 1.00 64.57  ? 197 ALA B CB  1 
ATOM   1298 N  N   . ALA A 1 205 ? 197.456 181.752 134.987 1.00 72.96  ? 198 ALA B N   1 
ATOM   1299 C  CA  . ALA A 1 205 ? 197.386 180.551 135.812 1.00 71.61  ? 198 ALA B CA  1 
ATOM   1300 C  C   . ALA A 1 205 ? 198.763 180.150 136.319 1.00 73.98  ? 198 ALA B C   1 
ATOM   1301 O  O   . ALA A 1 205 ? 198.911 179.724 137.468 1.00 78.25  ? 198 ALA B O   1 
ATOM   1302 C  CB  . ALA A 1 205 ? 196.749 179.409 135.026 1.00 68.54  ? 198 ALA B CB  1 
ATOM   1303 N  N   . GLU A 1 206 ? 199.787 180.284 135.477 1.00 73.00  ? 199 GLU B N   1 
ATOM   1304 C  CA  . GLU A 1 206 ? 201.146 179.992 135.914 1.00 74.24  ? 199 GLU B CA  1 
ATOM   1305 C  C   . GLU A 1 206 ? 201.620 180.995 136.956 1.00 74.58  ? 199 GLU B C   1 
ATOM   1306 O  O   . GLU A 1 206 ? 202.366 180.638 137.872 1.00 77.43  ? 199 GLU B O   1 
ATOM   1307 C  CB  . GLU A 1 206 ? 202.093 179.974 134.718 1.00 75.65  ? 199 GLU B CB  1 
ATOM   1308 C  CG  . GLU A 1 206 ? 201.944 178.753 133.842 1.00 80.10  ? 199 GLU B CG  1 
ATOM   1309 C  CD  . GLU A 1 206 ? 202.787 177.595 134.323 1.00 86.49  ? 199 GLU B CD  1 
ATOM   1310 O  OE1 . GLU A 1 206 ? 203.776 177.839 135.043 1.00 87.31  ? 199 GLU B OE1 1 
ATOM   1311 O  OE2 . GLU A 1 206 ? 202.461 176.439 133.982 1.00 89.37  ? 199 GLU B OE2 1 
ATOM   1312 N  N   . LEU A 1 207 ? 201.217 182.258 136.825 1.00 70.71  ? 200 LEU B N   1 
ATOM   1313 C  CA  . LEU A 1 207 ? 201.555 183.235 137.853 1.00 69.12  ? 200 LEU B CA  1 
ATOM   1314 C  C   . LEU A 1 207 ? 200.903 182.878 139.178 1.00 71.79  ? 200 LEU B C   1 
ATOM   1315 O  O   . LEU A 1 207 ? 201.546 182.938 140.230 1.00 76.42  ? 200 LEU B O   1 
ATOM   1316 C  CB  . LEU A 1 207 ? 201.131 184.633 137.418 1.00 67.25  ? 200 LEU B CB  1 
ATOM   1317 C  CG  . LEU A 1 207 ? 201.172 185.663 138.542 1.00 63.67  ? 200 LEU B CG  1 
ATOM   1318 C  CD1 . LEU A 1 207 ? 202.592 186.139 138.746 1.00 64.51  ? 200 LEU B CD1 1 
ATOM   1319 C  CD2 . LEU A 1 207 ? 200.256 186.825 138.235 1.00 67.93  ? 200 LEU B CD2 1 
ATOM   1320 N  N   . LEU A 1 208 ? 199.626 182.495 139.145 1.00 69.20  ? 201 LEU B N   1 
ATOM   1321 C  CA  . LEU A 1 208 ? 198.941 182.105 140.373 1.00 65.44  ? 201 LEU B CA  1 
ATOM   1322 C  C   . LEU A 1 208 ? 199.585 180.875 140.993 1.00 70.38  ? 201 LEU B C   1 
ATOM   1323 O  O   . LEU A 1 208 ? 199.723 180.790 142.218 1.00 75.25  ? 201 LEU B O   1 
ATOM   1324 C  CB  . LEU A 1 208 ? 197.464 181.841 140.101 1.00 64.08  ? 201 LEU B CB  1 
ATOM   1325 C  CG  . LEU A 1 208 ? 196.571 183.026 139.754 1.00 63.61  ? 201 LEU B CG  1 
ATOM   1326 C  CD1 . LEU A 1 208 ? 195.119 182.628 139.877 1.00 63.80  ? 201 LEU B CD1 1 
ATOM   1327 C  CD2 . LEU A 1 208 ? 196.877 184.195 140.647 1.00 63.76  ? 201 LEU B CD2 1 
ATOM   1328 N  N   . GLN A 1 209 ? 199.977 179.905 140.167 1.00 69.30  ? 202 GLN B N   1 
ATOM   1329 C  CA  . GLN A 1 209 ? 200.551 178.676 140.704 1.00 71.76  ? 202 GLN B CA  1 
ATOM   1330 C  C   . GLN A 1 209 ? 201.949 178.906 141.262 1.00 76.79  ? 202 GLN B C   1 
ATOM   1331 O  O   . GLN A 1 209 ? 202.275 178.412 142.347 1.00 80.91  ? 202 GLN B O   1 
ATOM   1332 C  CB  . GLN A 1 209 ? 200.576 177.594 139.628 1.00 76.68  ? 202 GLN B CB  1 
ATOM   1333 C  CG  . GLN A 1 209 ? 201.334 176.351 140.038 1.00 80.37  ? 202 GLN B CG  1 
ATOM   1334 C  CD  . GLN A 1 209 ? 202.077 175.723 138.884 1.00 89.37  ? 202 GLN B CD  1 
ATOM   1335 O  OE1 . GLN A 1 209 ? 201.479 175.069 138.031 1.00 92.13  ? 202 GLN B OE1 1 
ATOM   1336 N  NE2 . GLN A 1 209 ? 203.389 175.920 138.846 1.00 87.19  ? 202 GLN B NE2 1 
ATOM   1337 N  N   . GLU A 1 210 ? 202.792 179.644 140.536 1.00 75.11  ? 203 GLU B N   1 
ATOM   1338 C  CA  . GLU A 1 210 ? 204.168 179.847 140.978 1.00 74.40  ? 203 GLU B CA  1 
ATOM   1339 C  C   . GLU A 1 210 ? 204.229 180.631 142.281 1.00 75.55  ? 203 GLU B C   1 
ATOM   1340 O  O   . GLU A 1 210 ? 205.005 180.289 143.180 1.00 80.33  ? 203 GLU B O   1 
ATOM   1341 C  CB  . GLU A 1 210 ? 204.973 180.561 139.897 1.00 73.79  ? 203 GLU B CB  1 
ATOM   1342 C  CG  . GLU A 1 210 ? 206.150 181.340 140.451 1.00 80.44  ? 203 GLU B CG  1 
ATOM   1343 C  CD  . GLU A 1 210 ? 207.293 181.457 139.473 1.00 86.56  ? 203 GLU B CD  1 
ATOM   1344 O  OE1 . GLU A 1 210 ? 207.209 180.857 138.382 1.00 90.09  ? 203 GLU B OE1 1 
ATOM   1345 O  OE2 . GLU A 1 210 ? 208.280 182.146 139.800 1.00 84.42  ? 203 GLU B OE2 1 
ATOM   1346 N  N   . PHE A 1 211 ? 203.424 181.684 142.406 1.00 70.38  ? 204 PHE B N   1 
ATOM   1347 C  CA  . PHE A 1 211 ? 203.442 182.472 143.629 1.00 69.09  ? 204 PHE B CA  1 
ATOM   1348 C  C   . PHE A 1 211 ? 202.799 181.752 144.803 1.00 72.27  ? 204 PHE B C   1 
ATOM   1349 O  O   . PHE A 1 211 ? 202.938 182.214 145.938 1.00 72.92  ? 204 PHE B O   1 
ATOM   1350 C  CB  . PHE A 1 211 ? 202.751 183.813 143.402 1.00 70.09  ? 204 PHE B CB  1 
ATOM   1351 C  CG  . PHE A 1 211 ? 203.692 184.921 143.038 1.00 75.60  ? 204 PHE B CG  1 
ATOM   1352 C  CD1 . PHE A 1 211 ? 204.955 184.981 143.592 1.00 79.62  ? 204 PHE B CD1 1 
ATOM   1353 C  CD2 . PHE A 1 211 ? 203.313 185.905 142.150 1.00 73.39  ? 204 PHE B CD2 1 
ATOM   1354 C  CE1 . PHE A 1 211 ? 205.822 185.998 143.262 1.00 81.72  ? 204 PHE B CE1 1 
ATOM   1355 C  CE2 . PHE A 1 211 ? 204.176 186.924 141.818 1.00 71.52  ? 204 PHE B CE2 1 
ATOM   1356 C  CZ  . PHE A 1 211 ? 205.431 186.970 142.374 1.00 79.73  ? 204 PHE B CZ  1 
ATOM   1357 N  N   . GLY A 1 212 ? 202.109 180.642 144.565 1.00 73.96  ? 205 GLY B N   1 
ATOM   1358 C  CA  . GLY A 1 212 ? 201.548 179.847 145.635 1.00 71.58  ? 205 GLY B CA  1 
ATOM   1359 C  C   . GLY A 1 212 ? 200.130 180.182 146.029 1.00 69.42  ? 205 GLY B C   1 
ATOM   1360 O  O   . GLY A 1 212 ? 199.683 179.742 147.093 1.00 72.63  ? 205 GLY B O   1 
ATOM   1361 N  N   . TRP A 1 213 ? 199.406 180.941 145.213 1.00 66.26  ? 206 TRP B N   1 
ATOM   1362 C  CA  . TRP A 1 213 ? 198.019 181.291 145.504 1.00 67.99  ? 206 TRP B CA  1 
ATOM   1363 C  C   . TRP A 1 213 ? 197.119 180.244 144.865 1.00 66.43  ? 206 TRP B C   1 
ATOM   1364 O  O   . TRP A 1 213 ? 196.772 180.330 143.690 1.00 71.37  ? 206 TRP B O   1 
ATOM   1365 C  CB  . TRP A 1 213 ? 197.690 182.681 144.981 1.00 71.80  ? 206 TRP B CB  1 
ATOM   1366 C  CG  . TRP A 1 213 ? 198.649 183.748 145.387 1.00 72.76  ? 206 TRP B CG  1 
ATOM   1367 C  CD1 . TRP A 1 213 ? 199.345 183.827 146.553 1.00 73.90  ? 206 TRP B CD1 1 
ATOM   1368 C  CD2 . TRP A 1 213 ? 199.017 184.899 144.622 1.00 68.16  ? 206 TRP B CD2 1 
ATOM   1369 N  NE1 . TRP A 1 213 ? 200.124 184.957 146.562 1.00 74.51  ? 206 TRP B NE1 1 
ATOM   1370 C  CE2 . TRP A 1 213 ? 199.938 185.631 145.385 1.00 69.95  ? 206 TRP B CE2 1 
ATOM   1371 C  CE3 . TRP A 1 213 ? 198.655 185.378 143.364 1.00 66.07  ? 206 TRP B CE3 1 
ATOM   1372 C  CZ2 . TRP A 1 213 ? 200.501 186.815 144.931 1.00 69.25  ? 206 TRP B CZ2 1 
ATOM   1373 C  CZ3 . TRP A 1 213 ? 199.212 186.550 142.917 1.00 64.62  ? 206 TRP B CZ3 1 
ATOM   1374 C  CH2 . TRP A 1 213 ? 200.125 187.257 143.696 1.00 65.89  ? 206 TRP B CH2 1 
ATOM   1375 N  N   . ASN A 1 214 ? 196.721 179.243 145.645 1.00 65.71  ? 207 ASN B N   1 
ATOM   1376 C  CA  . ASN A 1 214 ? 195.829 178.208 145.147 1.00 68.75  ? 207 ASN B CA  1 
ATOM   1377 C  C   . ASN A 1 214 ? 194.407 178.369 145.669 1.00 71.07  ? 207 ASN B C   1 
ATOM   1378 O  O   . ASN A 1 214 ? 193.646 177.397 145.692 1.00 73.18  ? 207 ASN B O   1 
ATOM   1379 C  CB  . ASN A 1 214 ? 196.376 176.820 145.482 1.00 69.82  ? 207 ASN B CB  1 
ATOM   1380 C  CG  . ASN A 1 214 ? 196.422 176.550 146.964 1.00 72.48  ? 207 ASN B CG  1 
ATOM   1381 O  OD1 . ASN A 1 214 ? 195.413 176.203 147.575 1.00 78.68  ? 207 ASN B OD1 1 
ATOM   1382 N  ND2 . ASN A 1 214 ? 197.603 176.690 147.553 1.00 71.18  ? 207 ASN B ND2 1 
ATOM   1383 N  N   . TRP A 1 215 ? 194.036 179.576 146.088 1.00 70.51  ? 208 TRP B N   1 
ATOM   1384 C  CA  . TRP A 1 215 ? 192.676 179.888 146.538 1.00 74.49  ? 208 TRP B CA  1 
ATOM   1385 C  C   . TRP A 1 215 ? 192.339 181.262 145.968 1.00 76.24  ? 208 TRP B C   1 
ATOM   1386 O  O   . TRP A 1 215 ? 192.594 182.287 146.601 1.00 82.15  ? 208 TRP B O   1 
ATOM   1387 C  CB  . TRP A 1 215 ? 192.583 179.858 148.056 1.00 73.46  ? 208 TRP B CB  1 
ATOM   1388 C  CG  . TRP A 1 215 ? 191.249 180.223 148.608 1.00 72.25  ? 208 TRP B CG  1 
ATOM   1389 C  CD1 . TRP A 1 215 ? 190.957 181.302 149.375 1.00 72.43  ? 208 TRP B CD1 1 
ATOM   1390 C  CD2 . TRP A 1 215 ? 190.027 179.497 148.453 1.00 76.81  ? 208 TRP B CD2 1 
ATOM   1391 N  NE1 . TRP A 1 215 ? 189.629 181.301 149.708 1.00 77.73  ? 208 TRP B NE1 1 
ATOM   1392 C  CE2 . TRP A 1 215 ? 189.035 180.202 149.150 1.00 78.30  ? 208 TRP B CE2 1 
ATOM   1393 C  CE3 . TRP A 1 215 ? 189.677 178.322 147.790 1.00 80.05  ? 208 TRP B CE3 1 
ATOM   1394 C  CZ2 . TRP A 1 215 ? 187.718 179.771 149.205 1.00 79.25  ? 208 TRP B CZ2 1 
ATOM   1395 C  CZ3 . TRP A 1 215 ? 188.369 177.898 147.844 1.00 78.88  ? 208 TRP B CZ3 1 
ATOM   1396 C  CH2 . TRP A 1 215 ? 187.405 178.621 148.544 1.00 78.03  ? 208 TRP B CH2 1 
ATOM   1397 N  N   . VAL A 1 216 ? 191.757 181.276 144.774 1.00 70.18  ? 209 VAL B N   1 
ATOM   1398 C  CA  . VAL A 1 216 ? 191.585 182.497 144.003 1.00 63.12  ? 209 VAL B CA  1 
ATOM   1399 C  C   . VAL A 1 216 ? 190.127 182.633 143.599 1.00 64.74  ? 209 VAL B C   1 
ATOM   1400 O  O   . VAL A 1 216 ? 189.391 181.646 143.524 1.00 70.56  ? 209 VAL B O   1 
ATOM   1401 C  CB  . VAL A 1 216 ? 192.501 182.497 142.763 1.00 66.56  ? 209 VAL B CB  1 
ATOM   1402 C  CG1 . VAL A 1 216 ? 191.889 181.668 141.658 1.00 72.37  ? 209 VAL B CG1 1 
ATOM   1403 C  CG2 . VAL A 1 216 ? 192.744 183.897 142.283 1.00 69.47  ? 209 VAL B CG2 1 
ATOM   1404 N  N   . ALA A 1 217 ? 189.706 183.869 143.348 1.00 66.65  ? 210 ALA B N   1 
ATOM   1405 C  CA  . ALA A 1 217 ? 188.366 184.173 142.867 1.00 67.75  ? 210 ALA B CA  1 
ATOM   1406 C  C   . ALA A 1 217 ? 188.461 184.730 141.456 1.00 68.28  ? 210 ALA B C   1 
ATOM   1407 O  O   . ALA A 1 217 ? 189.275 185.618 141.191 1.00 70.11  ? 210 ALA B O   1 
ATOM   1408 C  CB  . ALA A 1 217 ? 187.663 185.175 143.781 1.00 63.98  ? 210 ALA B CB  1 
ATOM   1409 N  N   . ALA A 1 218 ? 187.636 184.212 140.555 1.00 70.14  ? 211 ALA B N   1 
ATOM   1410 C  CA  . ALA A 1 218 ? 187.686 184.578 139.149 1.00 68.45  ? 211 ALA B CA  1 
ATOM   1411 C  C   . ALA A 1 218 ? 186.421 185.323 138.751 1.00 73.54  ? 211 ALA B C   1 
ATOM   1412 O  O   . ALA A 1 218 ? 185.313 184.925 139.118 1.00 81.17  ? 211 ALA B O   1 
ATOM   1413 C  CB  . ALA A 1 218 ? 187.862 183.342 138.268 1.00 66.35  ? 211 ALA B CB  1 
ATOM   1414 N  N   . LEU A 1 219 ? 186.594 186.404 137.999 1.00 67.54  ? 212 LEU B N   1 
ATOM   1415 C  CA  . LEU A 1 219 ? 185.491 187.219 137.522 1.00 70.21  ? 212 LEU B CA  1 
ATOM   1416 C  C   . LEU A 1 219 ? 185.653 187.452 136.028 1.00 75.80  ? 212 LEU B C   1 
ATOM   1417 O  O   . LEU A 1 219 ? 186.719 187.221 135.457 1.00 79.24  ? 212 LEU B O   1 
ATOM   1418 C  CB  . LEU A 1 219 ? 185.421 188.562 138.256 1.00 68.43  ? 212 LEU B CB  1 
ATOM   1419 C  CG  . LEU A 1 219 ? 185.238 188.519 139.771 1.00 65.42  ? 212 LEU B CG  1 
ATOM   1420 C  CD1 . LEU A 1 219 ? 185.198 189.923 140.335 1.00 62.88  ? 212 LEU B CD1 1 
ATOM   1421 C  CD2 . LEU A 1 219 ? 183.978 187.762 140.131 1.00 69.71  ? 212 LEU B CD2 1 
ATOM   1422 N  N   . GLY A 1 220 ? 184.582 187.911 135.397 1.00 76.01  ? 213 GLY B N   1 
ATOM   1423 C  CA  . GLY A 1 220 ? 184.627 188.205 133.979 1.00 74.35  ? 213 GLY B CA  1 
ATOM   1424 C  C   . GLY A 1 220 ? 183.441 189.042 133.567 1.00 78.68  ? 213 GLY B C   1 
ATOM   1425 O  O   . GLY A 1 220 ? 182.438 189.126 134.281 1.00 80.45  ? 213 GLY B O   1 
ATOM   1426 N  N   . SER A 1 221 ? 183.569 189.661 132.397 1.00 83.34  ? 214 SER B N   1 
ATOM   1427 C  CA  . SER A 1 221 ? 182.490 190.479 131.868 1.00 89.20  ? 214 SER B CA  1 
ATOM   1428 C  C   . SER A 1 221 ? 181.314 189.609 131.442 1.00 95.30  ? 214 SER B C   1 
ATOM   1429 O  O   . SER A 1 221 ? 181.460 188.424 131.137 1.00 99.20  ? 214 SER B O   1 
ATOM   1430 C  CB  . SER A 1 221 ? 182.970 191.301 130.677 1.00 89.61  ? 214 SER B CB  1 
ATOM   1431 O  OG  . SER A 1 221 ? 183.886 192.295 131.081 1.00 89.53  ? 214 SER B OG  1 
ATOM   1432 N  N   . ASP A 1 222 ? 180.129 190.219 131.419 1.00 93.30  ? 215 ASP B N   1 
ATOM   1433 C  CA  . ASP A 1 222 ? 178.954 189.496 130.956 1.00 97.73  ? 215 ASP B CA  1 
ATOM   1434 C  C   . ASP A 1 222 ? 178.967 189.289 129.450 1.00 102.42 ? 215 ASP B C   1 
ATOM   1435 O  O   . ASP A 1 222 ? 178.222 188.441 128.949 1.00 105.38 ? 215 ASP B O   1 
ATOM   1436 C  CB  . ASP A 1 222 ? 177.680 190.226 131.371 1.00 99.81  ? 215 ASP B CB  1 
ATOM   1437 C  CG  . ASP A 1 222 ? 176.542 189.275 131.675 1.00 106.97 ? 215 ASP B CG  1 
ATOM   1438 O  OD1 . ASP A 1 222 ? 176.048 188.617 130.736 1.00 107.89 ? 215 ASP B OD1 1 
ATOM   1439 O  OD2 . ASP A 1 222 ? 176.144 189.177 132.853 1.00 107.86 ? 215 ASP B OD2 1 
ATOM   1440 N  N   . ASP A 1 223 ? 179.793 190.034 128.720 1.00 98.75  ? 216 ASP B N   1 
ATOM   1441 C  CA  . ASP A 1 223 ? 179.898 189.831 127.286 1.00 97.85  ? 216 ASP B CA  1 
ATOM   1442 C  C   . ASP A 1 223 ? 180.551 188.484 126.996 1.00 94.87  ? 216 ASP B C   1 
ATOM   1443 O  O   . ASP A 1 223 ? 181.035 187.789 127.892 1.00 95.03  ? 216 ASP B O   1 
ATOM   1444 C  CB  . ASP A 1 223 ? 180.697 190.960 126.639 1.00 98.56  ? 216 ASP B CB  1 
ATOM   1445 C  CG  . ASP A 1 223 ? 181.988 191.254 127.370 1.00 94.25  ? 216 ASP B CG  1 
ATOM   1446 O  OD1 . ASP A 1 223 ? 182.786 190.318 127.575 1.00 92.55  ? 216 ASP B OD1 1 
ATOM   1447 O  OD2 . ASP A 1 223 ? 182.209 192.425 127.737 1.00 93.52  ? 216 ASP B OD2 1 
ATOM   1448 N  N   . GLU A 1 224 ? 180.566 188.116 125.715 1.00 95.18  ? 217 GLU B N   1 
ATOM   1449 C  CA  . GLU A 1 224 ? 181.149 186.835 125.334 1.00 98.19  ? 217 GLU B CA  1 
ATOM   1450 C  C   . GLU A 1 224 ? 182.618 186.749 125.713 1.00 96.43  ? 217 GLU B C   1 
ATOM   1451 O  O   . GLU A 1 224 ? 183.106 185.667 126.050 1.00 99.10  ? 217 GLU B O   1 
ATOM   1452 C  CB  . GLU A 1 224 ? 180.977 186.599 123.836 1.00 103.60 ? 217 GLU B CB  1 
ATOM   1453 C  CG  . GLU A 1 224 ? 181.084 185.139 123.436 1.00 108.43 ? 217 GLU B CG  1 
ATOM   1454 C  CD  . GLU A 1 224 ? 180.092 184.259 124.168 1.00 112.33 ? 217 GLU B CD  1 
ATOM   1455 O  OE1 . GLU A 1 224 ? 178.920 184.667 124.309 1.00 113.90 ? 217 GLU B OE1 1 
ATOM   1456 O  OE2 . GLU A 1 224 ? 180.485 183.158 124.604 1.00 108.26 ? 217 GLU B OE2 1 
ATOM   1457 N  N   . TYR A 1 225 ? 183.334 187.872 125.676 1.00 92.52  ? 218 TYR B N   1 
ATOM   1458 C  CA  . TYR A 1 225 ? 184.761 187.860 125.981 1.00 91.04  ? 218 TYR B CA  1 
ATOM   1459 C  C   . TYR A 1 225 ? 185.019 187.354 127.396 1.00 90.28  ? 218 TYR B C   1 
ATOM   1460 O  O   . TYR A 1 225 ? 185.826 186.439 127.607 1.00 91.42  ? 218 TYR B O   1 
ATOM   1461 C  CB  . TYR A 1 225 ? 185.325 189.266 125.781 1.00 92.02  ? 218 TYR B CB  1 
ATOM   1462 C  CG  . TYR A 1 225 ? 186.676 189.523 126.395 1.00 89.26  ? 218 TYR B CG  1 
ATOM   1463 C  CD1 . TYR A 1 225 ? 187.830 189.043 125.801 1.00 89.33  ? 218 TYR B CD1 1 
ATOM   1464 C  CD2 . TYR A 1 225 ? 186.800 190.278 127.547 1.00 86.79  ? 218 TYR B CD2 1 
ATOM   1465 C  CE1 . TYR A 1 225 ? 189.067 189.290 126.349 1.00 88.14  ? 218 TYR B CE1 1 
ATOM   1466 C  CE2 . TYR A 1 225 ? 188.032 190.531 128.101 1.00 85.58  ? 218 TYR B CE2 1 
ATOM   1467 C  CZ  . TYR A 1 225 ? 189.162 190.035 127.499 1.00 85.47  ? 218 TYR B CZ  1 
ATOM   1468 O  OH  . TYR A 1 225 ? 190.394 190.285 128.053 1.00 83.79  ? 218 TYR B OH  1 
ATOM   1469 N  N   . GLY A 1 226 ? 184.314 187.918 128.377 1.00 89.78  ? 219 GLY B N   1 
ATOM   1470 C  CA  . GLY A 1 226 ? 184.506 187.491 129.752 1.00 86.52  ? 219 GLY B CA  1 
ATOM   1471 C  C   . GLY A 1 226 ? 184.068 186.061 129.997 1.00 84.39  ? 219 GLY B C   1 
ATOM   1472 O  O   . GLY A 1 226 ? 184.735 185.317 130.719 1.00 85.93  ? 219 GLY B O   1 
ATOM   1473 N  N   . ARG A 1 227 ? 182.938 185.659 129.413 1.00 84.91  ? 220 ARG B N   1 
ATOM   1474 C  CA  . ARG A 1 227 ? 182.459 184.295 129.605 1.00 84.93  ? 220 ARG B CA  1 
ATOM   1475 C  C   . ARG A 1 227 ? 183.441 183.282 129.033 1.00 88.36  ? 220 ARG B C   1 
ATOM   1476 O  O   . ARG A 1 227 ? 183.733 182.261 129.667 1.00 91.53  ? 220 ARG B O   1 
ATOM   1477 C  CB  . ARG A 1 227 ? 181.080 184.131 128.970 1.00 89.25  ? 220 ARG B CB  1 
ATOM   1478 C  CG  . ARG A 1 227 ? 180.079 185.185 129.408 1.00 93.75  ? 220 ARG B CG  1 
ATOM   1479 C  CD  . ARG A 1 227 ? 178.825 185.167 128.553 1.00 102.51 ? 220 ARG B CD  1 
ATOM   1480 N  NE  . ARG A 1 227 ? 177.768 184.349 129.133 1.00 109.43 ? 220 ARG B NE  1 
ATOM   1481 C  CZ  . ARG A 1 227 ? 176.498 184.722 129.216 1.00 107.78 ? 220 ARG B CZ  1 
ATOM   1482 N  NH1 . ARG A 1 227 ? 176.093 185.898 128.765 1.00 104.19 ? 220 ARG B NH1 1 
ATOM   1483 N  NH2 . ARG A 1 227 ? 175.613 183.896 129.765 1.00 101.33 ? 220 ARG B NH2 1 
ATOM   1484 N  N   . GLN A 1 228 ? 183.972 183.550 127.837 1.00 89.49  ? 221 GLN B N   1 
ATOM   1485 C  CA  . GLN A 1 228 ? 184.966 182.655 127.258 1.00 88.17  ? 221 GLN B CA  1 
ATOM   1486 C  C   . GLN A 1 228 ? 186.229 182.618 128.105 1.00 88.79  ? 221 GLN B C   1 
ATOM   1487 O  O   . GLN A 1 228 ? 186.791 181.541 128.346 1.00 88.53  ? 221 GLN B O   1 
ATOM   1488 C  CB  . GLN A 1 228 ? 185.298 183.081 125.829 1.00 88.97  ? 221 GLN B CB  1 
ATOM   1489 C  CG  . GLN A 1 228 ? 184.112 183.054 124.891 1.00 93.65  ? 221 GLN B CG  1 
ATOM   1490 C  CD  . GLN A 1 228 ? 183.862 181.687 124.308 1.00 98.81  ? 221 GLN B CD  1 
ATOM   1491 O  OE1 . GLN A 1 228 ? 184.753 180.840 124.274 1.00 104.10 ? 221 GLN B OE1 1 
ATOM   1492 N  NE2 . GLN A 1 228 ? 182.638 181.457 123.856 1.00 97.56  ? 221 GLN B NE2 1 
ATOM   1493 N  N   . GLY A 1 229 ? 186.692 183.780 128.566 1.00 86.48  ? 222 GLY B N   1 
ATOM   1494 C  CA  . GLY A 1 229 ? 187.863 183.794 129.423 1.00 81.30  ? 222 GLY B CA  1 
ATOM   1495 C  C   . GLY A 1 229 ? 187.668 182.965 130.676 1.00 80.44  ? 222 GLY B C   1 
ATOM   1496 O  O   . GLY A 1 229 ? 188.547 182.195 131.065 1.00 80.34  ? 222 GLY B O   1 
ATOM   1497 N  N   . LEU A 1 230 ? 186.505 183.098 131.311 1.00 81.85  ? 223 LEU B N   1 
ATOM   1498 C  CA  . LEU A 1 230 ? 186.218 182.319 132.509 1.00 80.06  ? 223 LEU B CA  1 
ATOM   1499 C  C   . LEU A 1 230 ? 186.171 180.830 132.207 1.00 82.65  ? 223 LEU B C   1 
ATOM   1500 O  O   . LEU A 1 230 ? 186.674 180.015 132.989 1.00 84.09  ? 223 LEU B O   1 
ATOM   1501 C  CB  . LEU A 1 230 ? 184.899 182.772 133.122 1.00 77.31  ? 223 LEU B CB  1 
ATOM   1502 C  CG  . LEU A 1 230 ? 185.031 183.514 134.441 1.00 77.02  ? 223 LEU B CG  1 
ATOM   1503 C  CD1 . LEU A 1 230 ? 183.660 183.828 134.981 1.00 80.81  ? 223 LEU B CD1 1 
ATOM   1504 C  CD2 . LEU A 1 230 ? 185.804 182.659 135.410 1.00 76.61  ? 223 LEU B CD2 1 
ATOM   1505 N  N   . SER A 1 231 ? 185.551 180.451 131.089 1.00 84.25  ? 224 SER B N   1 
ATOM   1506 C  CA  . SER A 1 231 ? 185.448 179.035 130.757 1.00 82.47  ? 224 SER B CA  1 
ATOM   1507 C  C   . SER A 1 231 ? 186.821 178.422 130.531 1.00 81.53  ? 224 SER B C   1 
ATOM   1508 O  O   . SER A 1 231 ? 187.077 177.290 130.955 1.00 79.65  ? 224 SER B O   1 
ATOM   1509 C  CB  . SER A 1 231 ? 184.567 178.839 129.528 1.00 84.67  ? 224 SER B CB  1 
ATOM   1510 O  OG  . SER A 1 231 ? 184.254 177.469 129.356 1.00 86.20  ? 224 SER B OG  1 
ATOM   1511 N  N   . ILE A 1 232 ? 187.716 179.146 129.856 1.00 83.56  ? 225 ILE B N   1 
ATOM   1512 C  CA  . ILE A 1 232 ? 189.070 178.624 129.676 1.00 82.31  ? 225 ILE B CA  1 
ATOM   1513 C  C   . ILE A 1 232 ? 189.819 178.593 131.002 1.00 79.30  ? 225 ILE B C   1 
ATOM   1514 O  O   . ILE A 1 232 ? 190.555 177.639 131.291 1.00 76.70  ? 225 ILE B O   1 
ATOM   1515 C  CB  . ILE A 1 232 ? 189.843 179.426 128.614 1.00 80.57  ? 225 ILE B CB  1 
ATOM   1516 C  CG1 . ILE A 1 232 ? 188.966 179.737 127.402 1.00 81.05  ? 225 ILE B CG1 1 
ATOM   1517 C  CG2 . ILE A 1 232 ? 191.083 178.672 128.193 1.00 80.31  ? 225 ILE B CG2 1 
ATOM   1518 C  CD1 . ILE A 1 232 ? 188.351 178.519 126.750 1.00 79.05  ? 225 ILE B CD1 1 
ATOM   1519 N  N   . PHE A 1 233 ? 189.655 179.629 131.827 1.00 79.72  ? 226 PHE B N   1 
ATOM   1520 C  CA  . PHE A 1 233 ? 190.436 179.693 133.053 1.00 77.37  ? 226 PHE B CA  1 
ATOM   1521 C  C   . PHE A 1 233 ? 190.011 178.634 134.056 1.00 79.36  ? 226 PHE B C   1 
ATOM   1522 O  O   . PHE A 1 233 ? 190.843 178.158 134.830 1.00 83.69  ? 226 PHE B O   1 
ATOM   1523 C  CB  . PHE A 1 233 ? 190.341 181.069 133.698 1.00 74.70  ? 226 PHE B CB  1 
ATOM   1524 C  CG  . PHE A 1 233 ? 191.198 181.207 134.915 1.00 73.60  ? 226 PHE B CG  1 
ATOM   1525 C  CD1 . PHE A 1 233 ? 192.571 181.271 134.797 1.00 72.42  ? 226 PHE B CD1 1 
ATOM   1526 C  CD2 . PHE A 1 233 ? 190.640 181.234 136.176 1.00 71.73  ? 226 PHE B CD2 1 
ATOM   1527 C  CE1 . PHE A 1 233 ? 193.368 181.383 135.907 1.00 70.48  ? 226 PHE B CE1 1 
ATOM   1528 C  CE2 . PHE A 1 233 ? 191.437 181.346 137.292 1.00 69.15  ? 226 PHE B CE2 1 
ATOM   1529 C  CZ  . PHE A 1 233 ? 192.800 181.421 137.157 1.00 70.12  ? 226 PHE B CZ  1 
ATOM   1530 N  N   . SER A 1 234 ? 188.732 178.261 134.079 1.00 80.55  ? 227 SER B N   1 
ATOM   1531 C  CA  . SER A 1 234 ? 188.313 177.196 134.983 1.00 84.54  ? 227 SER B CA  1 
ATOM   1532 C  C   . SER A 1 234 ? 189.030 175.893 134.653 1.00 86.84  ? 227 SER B C   1 
ATOM   1533 O  O   . SER A 1 234 ? 189.535 175.203 135.546 1.00 87.60  ? 227 SER B O   1 
ATOM   1534 C  CB  . SER A 1 234 ? 186.799 177.015 134.923 1.00 84.92  ? 227 SER B CB  1 
ATOM   1535 O  OG  . SER A 1 234 ? 186.136 178.175 135.391 1.00 87.18  ? 227 SER B OG  1 
ATOM   1536 N  N   . ALA A 1 235 ? 189.103 175.551 133.365 1.00 84.49  ? 228 ALA B N   1 
ATOM   1537 C  CA  . ALA A 1 235 ? 189.817 174.345 132.960 1.00 81.45  ? 228 ALA B CA  1 
ATOM   1538 C  C   . ALA A 1 235 ? 191.305 174.453 133.261 1.00 82.22  ? 228 ALA B C   1 
ATOM   1539 O  O   . ALA A 1 235 ? 191.917 173.492 133.746 1.00 84.73  ? 228 ALA B O   1 
ATOM   1540 C  CB  . ALA A 1 235 ? 189.591 174.074 131.474 1.00 77.94  ? 228 ALA B CB  1 
ATOM   1541 N  N   . LEU A 1 236 ? 191.906 175.614 132.987 1.00 79.30  ? 229 LEU B N   1 
ATOM   1542 C  CA  . LEU A 1 236 ? 193.331 175.777 133.258 1.00 75.51  ? 229 LEU B CA  1 
ATOM   1543 C  C   . LEU A 1 236 ? 193.628 175.624 134.744 1.00 78.60  ? 229 LEU B C   1 
ATOM   1544 O  O   . LEU A 1 236 ? 194.599 174.959 135.128 1.00 82.83  ? 229 LEU B O   1 
ATOM   1545 C  CB  . LEU A 1 236 ? 193.810 177.135 132.756 1.00 73.10  ? 229 LEU B CB  1 
ATOM   1546 C  CG  . LEU A 1 236 ? 193.896 177.280 131.241 1.00 77.00  ? 229 LEU B CG  1 
ATOM   1547 C  CD1 . LEU A 1 236 ? 194.483 178.624 130.875 1.00 75.88  ? 229 LEU B CD1 1 
ATOM   1548 C  CD2 . LEU A 1 236 ? 194.719 176.156 130.652 1.00 81.46  ? 229 LEU B CD2 1 
ATOM   1549 N  N   . ALA A 1 237 ? 192.797 176.223 135.595 1.00 77.93  ? 230 ALA B N   1 
ATOM   1550 C  CA  . ALA A 1 237 ? 192.984 176.098 137.032 1.00 78.50  ? 230 ALA B CA  1 
ATOM   1551 C  C   . ALA A 1 237 ? 192.822 174.654 137.478 1.00 82.38  ? 230 ALA B C   1 
ATOM   1552 O  O   . ALA A 1 237 ? 193.679 174.113 138.185 1.00 83.93  ? 230 ALA B O   1 
ATOM   1553 C  CB  . ALA A 1 237 ? 191.997 177.002 137.765 1.00 78.01  ? 230 ALA B CB  1 
ATOM   1554 N  N   . ALA A 1 238 ? 191.736 174.002 137.056 1.00 85.03  ? 231 ALA B N   1 
ATOM   1555 C  CA  . ALA A 1 238 ? 191.517 172.615 137.447 1.00 87.81  ? 231 ALA B CA  1 
ATOM   1556 C  C   . ALA A 1 238 ? 192.672 171.725 137.014 1.00 89.22  ? 231 ALA B C   1 
ATOM   1557 O  O   . ALA A 1 238 ? 193.000 170.755 137.705 1.00 89.39  ? 231 ALA B O   1 
ATOM   1558 C  CB  . ALA A 1 238 ? 190.200 172.103 136.862 1.00 87.05  ? 231 ALA B CB  1 
ATOM   1559 N  N   . ALA A 1 239 ? 193.307 172.040 135.884 1.00 90.37  ? 232 ALA B N   1 
ATOM   1560 C  CA  . ALA A 1 239 ? 194.478 171.275 135.474 1.00 87.66  ? 232 ALA B CA  1 
ATOM   1561 C  C   . ALA A 1 239 ? 195.699 171.608 136.323 1.00 81.77  ? 232 ALA B C   1 
ATOM   1562 O  O   . ALA A 1 239 ? 196.534 170.732 136.569 1.00 77.92  ? 232 ALA B O   1 
ATOM   1563 C  CB  . ALA A 1 239 ? 194.778 171.521 133.997 1.00 85.32  ? 232 ALA B CB  1 
ATOM   1564 N  N   . ARG A 1 240 ? 195.826 172.853 136.777 1.00 81.63  ? 233 ARG B N   1 
ATOM   1565 C  CA  . ARG A 1 240 ? 197.022 173.291 137.485 1.00 79.91  ? 233 ARG B CA  1 
ATOM   1566 C  C   . ARG A 1 240 ? 196.914 173.179 139.002 1.00 81.98  ? 233 ARG B C   1 
ATOM   1567 O  O   . ARG A 1 240 ? 197.837 173.602 139.704 1.00 80.22  ? 233 ARG B O   1 
ATOM   1568 C  CB  . ARG A 1 240 ? 197.362 174.729 137.102 1.00 80.00  ? 233 ARG B CB  1 
ATOM   1569 C  CG  . ARG A 1 240 ? 198.505 174.842 136.121 1.00 81.54  ? 233 ARG B CG  1 
ATOM   1570 C  CD  . ARG A 1 240 ? 198.335 176.045 135.222 1.00 84.70  ? 233 ARG B CD  1 
ATOM   1571 N  NE  . ARG A 1 240 ? 199.028 175.869 133.953 1.00 87.02  ? 233 ARG B NE  1 
ATOM   1572 C  CZ  . ARG A 1 240 ? 198.565 175.150 132.942 1.00 88.53  ? 233 ARG B CZ  1 
ATOM   1573 N  NH1 . ARG A 1 240 ? 197.397 174.535 133.010 1.00 85.77  ? 233 ARG B NH1 1 
ATOM   1574 N  NH2 . ARG A 1 240 ? 199.293 175.045 131.835 1.00 87.15  ? 233 ARG B NH2 1 
ATOM   1575 N  N   . GLY A 1 241 ? 195.821 172.631 139.527 1.00 85.10  ? 234 GLY B N   1 
ATOM   1576 C  CA  . GLY A 1 241 ? 195.664 172.436 140.951 1.00 86.24  ? 234 GLY B CA  1 
ATOM   1577 C  C   . GLY A 1 241 ? 194.912 173.540 141.666 1.00 84.19  ? 234 GLY B C   1 
ATOM   1578 O  O   . GLY A 1 241 ? 194.278 173.282 142.693 1.00 85.20  ? 234 GLY B O   1 
ATOM   1579 N  N   . ILE A 1 242 ? 194.977 174.768 141.151 1.00 81.01  ? 235 ILE B N   1 
ATOM   1580 C  CA  . ILE A 1 242 ? 194.163 175.852 141.680 1.00 76.97  ? 235 ILE B CA  1 
ATOM   1581 C  C   . ILE A 1 242 ? 192.708 175.584 141.336 1.00 82.96  ? 235 ILE B C   1 
ATOM   1582 O  O   . ILE A 1 242 ? 192.407 174.856 140.384 1.00 89.23  ? 235 ILE B O   1 
ATOM   1583 C  CB  . ILE A 1 242 ? 194.631 177.184 141.075 1.00 75.19  ? 235 ILE B CB  1 
ATOM   1584 C  CG1 . ILE A 1 242 ? 196.143 177.312 141.198 1.00 75.78  ? 235 ILE B CG1 1 
ATOM   1585 C  CG2 . ILE A 1 242 ? 193.964 178.355 141.753 1.00 77.31  ? 235 ILE B CG2 1 
ATOM   1586 C  CD1 . ILE A 1 242 ? 196.722 178.333 140.268 1.00 72.10  ? 235 ILE B CD1 1 
ATOM   1587 N  N   . CYS A 1 243 ? 191.788 176.152 142.110 1.00 80.26  ? 236 CYS B N   1 
ATOM   1588 C  CA  . CYS A 1 243 ? 190.430 176.306 141.613 1.00 89.69  ? 236 CYS B CA  1 
ATOM   1589 C  C   . CYS A 1 243 ? 189.697 177.407 142.365 1.00 81.17  ? 236 CYS B C   1 
ATOM   1590 O  O   . CYS A 1 243 ? 190.112 177.856 143.436 1.00 77.55  ? 236 CYS B O   1 
ATOM   1591 C  CB  . CYS A 1 243 ? 189.626 175.001 141.669 1.00 99.08  ? 236 CYS B CB  1 
ATOM   1592 S  SG  . CYS A 1 243 ? 188.881 174.586 143.226 1.00 112.63 ? 236 CYS B SG  1 
ATOM   1593 N  N   . ILE A 1 244 ? 188.583 177.813 141.777 1.00 75.36  ? 237 ILE B N   1 
ATOM   1594 C  CA  . ILE A 1 244 ? 187.960 179.098 142.044 1.00 71.42  ? 237 ILE B CA  1 
ATOM   1595 C  C   . ILE A 1 244 ? 187.147 179.023 143.326 1.00 79.57  ? 237 ILE B C   1 
ATOM   1596 O  O   . ILE A 1 244 ? 186.459 178.029 143.581 1.00 85.03  ? 237 ILE B O   1 
ATOM   1597 C  CB  . ILE A 1 244 ? 187.077 179.515 140.860 1.00 70.87  ? 237 ILE B CB  1 
ATOM   1598 C  CG1 . ILE A 1 244 ? 187.801 179.224 139.549 1.00 72.60  ? 237 ILE B CG1 1 
ATOM   1599 C  CG2 . ILE A 1 244 ? 186.721 180.976 140.947 1.00 75.03  ? 237 ILE B CG2 1 
ATOM   1600 C  CD1 . ILE A 1 244 ? 189.122 179.933 139.422 1.00 72.56  ? 237 ILE B CD1 1 
ATOM   1601 N  N   . ALA A 1 245 ? 187.238 180.073 144.142 1.00 79.51  ? 238 ALA B N   1 
ATOM   1602 C  CA  . ALA A 1 245 ? 186.329 180.232 145.269 1.00 77.21  ? 238 ALA B CA  1 
ATOM   1603 C  C   . ALA A 1 245 ? 184.942 180.638 144.796 1.00 74.92  ? 238 ALA B C   1 
ATOM   1604 O  O   . ALA A 1 245 ? 183.936 180.082 145.244 1.00 76.97  ? 238 ALA B O   1 
ATOM   1605 C  CB  . ALA A 1 245 ? 186.880 181.269 146.244 1.00 74.18  ? 238 ALA B CB  1 
ATOM   1606 N  N   . HIS A 1 246 ? 184.874 181.602 143.883 1.00 72.16  ? 239 HIS B N   1 
ATOM   1607 C  CA  . HIS A 1 246 ? 183.606 182.069 143.345 1.00 78.17  ? 239 HIS B CA  1 
ATOM   1608 C  C   . HIS A 1 246 ? 183.824 182.541 141.918 1.00 79.17  ? 239 HIS B C   1 
ATOM   1609 O  O   . HIS A 1 246 ? 184.693 183.378 141.668 1.00 78.07  ? 239 HIS B O   1 
ATOM   1610 C  CB  . HIS A 1 246 ? 183.029 183.200 144.195 1.00 84.26  ? 239 HIS B CB  1 
ATOM   1611 C  CG  . HIS A 1 246 ? 181.756 183.767 143.655 1.00 91.62  ? 239 HIS B CG  1 
ATOM   1612 N  ND1 . HIS A 1 246 ? 181.698 184.983 143.011 1.00 92.23  ? 239 HIS B ND1 1 
ATOM   1613 C  CD2 . HIS A 1 246 ? 180.493 183.279 143.655 1.00 91.60  ? 239 HIS B CD2 1 
ATOM   1614 C  CE1 . HIS A 1 246 ? 180.453 185.223 142.640 1.00 91.40  ? 239 HIS B CE1 1 
ATOM   1615 N  NE2 . HIS A 1 246 ? 179.702 184.205 143.020 1.00 93.54  ? 239 HIS B NE2 1 
ATOM   1616 N  N   . GLU A 1 247 ? 183.040 182.005 140.993 1.00 80.51  ? 240 GLU B N   1 
ATOM   1617 C  CA  . GLU A 1 247 ? 183.127 182.348 139.577 1.00 82.67  ? 240 GLU B CA  1 
ATOM   1618 C  C   . GLU A 1 247 ? 181.865 183.144 139.251 1.00 86.50  ? 240 GLU B C   1 
ATOM   1619 O  O   . GLU A 1 247 ? 180.758 182.604 139.224 1.00 92.70  ? 240 GLU B O   1 
ATOM   1620 C  CB  . GLU A 1 247 ? 183.268 181.091 138.712 1.00 83.73  ? 240 GLU B CB  1 
ATOM   1621 C  CG  . GLU A 1 247 ? 182.545 181.136 137.374 1.00 89.40  ? 240 GLU B CG  1 
ATOM   1622 C  CD  . GLU A 1 247 ? 182.843 179.934 136.504 1.00 97.33  ? 240 GLU B CD  1 
ATOM   1623 O  OE1 . GLU A 1 247 ? 182.135 179.744 135.492 1.00 102.26 ? 240 GLU B OE1 1 
ATOM   1624 O  OE2 . GLU A 1 247 ? 183.773 179.172 136.836 1.00 94.20  ? 240 GLU B OE2 1 
ATOM   1625 N  N   . GLY A 1 248 ? 182.034 184.450 139.047 1.00 79.66  ? 241 GLY B N   1 
ATOM   1626 C  CA  . GLY A 1 248 ? 180.930 185.347 138.804 1.00 80.07  ? 241 GLY B CA  1 
ATOM   1627 C  C   . GLY A 1 248 ? 181.082 186.103 137.496 1.00 81.83  ? 241 GLY B C   1 
ATOM   1628 O  O   . GLY A 1 248 ? 182.056 185.939 136.759 1.00 83.04  ? 241 GLY B O   1 
ATOM   1629 N  N   . LEU A 1 249 ? 180.084 186.938 137.223 1.00 83.70  ? 242 LEU B N   1 
ATOM   1630 C  CA  . LEU A 1 249 ? 180.076 187.796 136.048 1.00 82.39  ? 242 LEU B CA  1 
ATOM   1631 C  C   . LEU A 1 249 ? 179.690 189.204 136.469 1.00 81.96  ? 242 LEU B C   1 
ATOM   1632 O  O   . LEU A 1 249 ? 178.721 189.388 137.209 1.00 79.01  ? 242 LEU B O   1 
ATOM   1633 C  CB  . LEU A 1 249 ? 179.106 187.275 134.986 1.00 81.58  ? 242 LEU B CB  1 
ATOM   1634 C  CG  . LEU A 1 249 ? 179.565 186.030 134.233 1.00 77.13  ? 242 LEU B CG  1 
ATOM   1635 C  CD1 . LEU A 1 249 ? 178.602 185.712 133.113 1.00 86.88  ? 242 LEU B CD1 1 
ATOM   1636 C  CD2 . LEU A 1 249 ? 180.963 186.230 133.695 1.00 79.56  ? 242 LEU B CD2 1 
ATOM   1637 N  N   . VAL A 1 250 ? 180.440 190.191 135.994 1.00 83.18  ? 243 VAL B N   1 
ATOM   1638 C  CA  . VAL A 1 250 ? 180.194 191.595 136.310 1.00 84.00  ? 243 VAL B CA  1 
ATOM   1639 C  C   . VAL A 1 250 ? 179.466 192.232 135.131 1.00 86.94  ? 243 VAL B C   1 
ATOM   1640 O  O   . VAL A 1 250 ? 180.031 192.296 134.030 1.00 87.11  ? 243 VAL B O   1 
ATOM   1641 C  CB  . VAL A 1 250 ? 181.499 192.334 136.636 1.00 78.58  ? 243 VAL B CB  1 
ATOM   1642 C  CG1 . VAL A 1 250 ? 182.000 191.883 137.979 1.00 77.88  ? 243 VAL B CG1 1 
ATOM   1643 C  CG2 . VAL A 1 250 ? 182.559 192.046 135.597 1.00 78.27  ? 243 VAL B CG2 1 
ATOM   1644 N  N   . PRO A 1 251 ? 178.227 192.682 135.301 1.00 88.48  ? 244 PRO B N   1 
ATOM   1645 C  CA  . PRO A 1 251 ? 177.485 193.233 134.165 1.00 92.51  ? 244 PRO B CA  1 
ATOM   1646 C  C   . PRO A 1 251 ? 178.072 194.549 133.692 1.00 92.38  ? 244 PRO B C   1 
ATOM   1647 O  O   . PRO A 1 251 ? 178.604 195.339 134.474 1.00 90.54  ? 244 PRO B O   1 
ATOM   1648 C  CB  . PRO A 1 251 ? 176.073 193.425 134.725 1.00 93.79  ? 244 PRO B CB  1 
ATOM   1649 C  CG  . PRO A 1 251 ? 176.273 193.577 136.187 1.00 93.39  ? 244 PRO B CG  1 
ATOM   1650 C  CD  . PRO A 1 251 ? 177.438 192.705 136.542 1.00 90.95  ? 244 PRO B CD  1 
ATOM   1651 N  N   . LEU A 1 252 ? 177.963 194.779 132.388 1.00 97.07  ? 245 LEU B N   1 
ATOM   1652 C  CA  . LEU A 1 252 ? 178.454 196.001 131.778 1.00 98.03  ? 245 LEU B CA  1 
ATOM   1653 C  C   . LEU A 1 252 ? 177.525 197.168 132.102 1.00 99.26  ? 245 LEU B C   1 
ATOM   1654 O  O   . LEU A 1 252 ? 176.315 196.984 132.253 1.00 100.91 ? 245 LEU B O   1 
ATOM   1655 C  CB  . LEU A 1 252 ? 178.559 195.832 130.269 1.00 100.69 ? 245 LEU B CB  1 
ATOM   1656 C  CG  . LEU A 1 252 ? 179.343 194.613 129.791 1.00 102.38 ? 245 LEU B CG  1 
ATOM   1657 C  CD1 . LEU A 1 252 ? 178.427 193.664 129.050 1.00 100.74 ? 245 LEU B CD1 1 
ATOM   1658 C  CD2 . LEU A 1 252 ? 180.497 195.039 128.907 1.00 99.08  ? 245 LEU B CD2 1 
ATOM   1659 N  N   . PRO A 1 253 ? 178.067 198.388 132.211 1.00 100.65 ? 246 PRO B N   1 
ATOM   1660 C  CA  . PRO A 1 253 ? 177.250 199.562 132.527 1.00 103.94 ? 246 PRO B CA  1 
ATOM   1661 C  C   . PRO A 1 253 ? 176.302 199.944 131.394 1.00 101.27 ? 246 PRO B C   1 
ATOM   1662 O  O   . PRO A 1 253 ? 176.420 199.388 130.303 1.00 100.18 ? 246 PRO B O   1 
ATOM   1663 C  CB  . PRO A 1 253 ? 178.291 200.659 132.756 1.00 102.27 ? 246 PRO B CB  1 
ATOM   1664 C  CG  . PRO A 1 253 ? 179.468 200.225 131.969 1.00 100.94 ? 246 PRO B CG  1 
ATOM   1665 C  CD  . PRO A 1 253 ? 179.490 198.731 132.063 1.00 97.27  ? 246 PRO B CD  1 
ATOM   1666 N  N   . LYS A 1 262 ? 173.589 192.021 141.119 1.00 105.72 ? 255 LYS B N   1 
ATOM   1667 C  CA  . LYS A 1 262 ? 174.459 192.605 140.107 1.00 106.68 ? 255 LYS B CA  1 
ATOM   1668 C  C   . LYS A 1 262 ? 175.906 192.710 140.590 1.00 110.06 ? 255 LYS B C   1 
ATOM   1669 O  O   . LYS A 1 262 ? 176.438 191.779 141.199 1.00 113.28 ? 255 LYS B O   1 
ATOM   1670 C  CB  . LYS A 1 262 ? 173.929 193.979 139.690 1.00 105.50 ? 255 LYS B CB  1 
ATOM   1671 C  CG  . LYS A 1 262 ? 173.666 194.938 140.841 1.00 106.49 ? 255 LYS B CG  1 
ATOM   1672 C  CD  . LYS A 1 262 ? 173.277 196.312 140.321 1.00 106.74 ? 255 LYS B CD  1 
ATOM   1673 C  CE  . LYS A 1 262 ? 173.076 197.297 141.457 1.00 107.56 ? 255 LYS B CE  1 
ATOM   1674 N  NZ  . LYS A 1 262 ? 172.708 198.644 140.946 1.00 107.65 ? 255 LYS B NZ  1 
ATOM   1675 N  N   . VAL A 1 263 ? 176.544 193.846 140.298 1.00 106.98 ? 256 VAL B N   1 
ATOM   1676 C  CA  . VAL A 1 263 ? 177.925 194.055 140.720 1.00 103.55 ? 256 VAL B CA  1 
ATOM   1677 C  C   . VAL A 1 263 ? 178.022 194.044 142.239 1.00 103.46 ? 256 VAL B C   1 
ATOM   1678 O  O   . VAL A 1 263 ? 179.001 193.548 142.812 1.00 104.95 ? 256 VAL B O   1 
ATOM   1679 C  CB  . VAL A 1 263 ? 178.469 195.363 140.119 1.00 100.63 ? 256 VAL B CB  1 
ATOM   1680 C  CG1 . VAL A 1 263 ? 177.516 196.510 140.400 1.00 102.96 ? 256 VAL B CG1 1 
ATOM   1681 C  CG2 . VAL A 1 263 ? 179.849 195.665 140.661 1.00 93.73  ? 256 VAL B CG2 1 
ATOM   1682 N  N   . GLN A 1 264 ? 177.007 194.581 142.917 1.00 103.00 ? 257 GLN B N   1 
ATOM   1683 C  CA  . GLN A 1 264 ? 176.982 194.542 144.375 1.00 105.88 ? 257 GLN B CA  1 
ATOM   1684 C  C   . GLN A 1 264 ? 176.996 193.105 144.878 1.00 104.07 ? 257 GLN B C   1 
ATOM   1685 O  O   . GLN A 1 264 ? 177.762 192.757 145.785 1.00 100.08 ? 257 GLN B O   1 
ATOM   1686 C  CB  . GLN A 1 264 ? 175.744 195.278 144.889 1.00 110.31 ? 257 GLN B CB  1 
ATOM   1687 C  CG  . GLN A 1 264 ? 175.726 196.761 144.578 1.00 106.85 ? 257 GLN B CG  1 
ATOM   1688 C  CD  . GLN A 1 264 ? 175.568 197.613 145.816 1.00 107.17 ? 257 GLN B CD  1 
ATOM   1689 O  OE1 . GLN A 1 264 ? 175.666 197.120 146.938 1.00 108.56 ? 257 GLN B OE1 1 
ATOM   1690 N  NE2 . GLN A 1 264 ? 175.321 198.902 145.620 1.00 102.13 ? 257 GLN B NE2 1 
ATOM   1691 N  N   . ASP A 1 265 ? 176.158 192.252 144.287 1.00 105.17 ? 258 ASP B N   1 
ATOM   1692 C  CA  . ASP A 1 265 ? 176.109 190.852 144.692 1.00 106.09 ? 258 ASP B CA  1 
ATOM   1693 C  C   . ASP A 1 265 ? 177.423 190.144 144.399 1.00 102.96 ? 258 ASP B C   1 
ATOM   1694 O  O   . ASP A 1 265 ? 177.882 189.321 145.199 1.00 104.66 ? 258 ASP B O   1 
ATOM   1695 C  CB  . ASP A 1 265 ? 174.956 190.146 143.985 1.00 113.01 ? 258 ASP B CB  1 
ATOM   1696 C  CG  . ASP A 1 265 ? 174.123 189.308 144.927 1.00 121.91 ? 258 ASP B CG  1 
ATOM   1697 O  OD1 . ASP A 1 265 ? 174.403 189.326 146.144 1.00 120.50 ? 258 ASP B OD1 1 
ATOM   1698 O  OD2 . ASP A 1 265 ? 173.189 188.630 144.450 1.00 125.49 ? 258 ASP B OD2 1 
ATOM   1699 N  N   . VAL A 1 266 ? 178.034 190.436 143.250 1.00 100.41 ? 259 VAL B N   1 
ATOM   1700 C  CA  . VAL A 1 266 ? 179.302 189.799 142.908 1.00 99.69  ? 259 VAL B CA  1 
ATOM   1701 C  C   . VAL A 1 266 ? 180.380 190.186 143.911 1.00 98.62  ? 259 VAL B C   1 
ATOM   1702 O  O   . VAL A 1 266 ? 181.147 189.335 144.381 1.00 96.05  ? 259 VAL B O   1 
ATOM   1703 C  CB  . VAL A 1 266 ? 179.706 190.160 141.468 1.00 100.62 ? 259 VAL B CB  1 
ATOM   1704 C  CG1 . VAL A 1 266 ? 181.180 189.888 141.246 1.00 95.84  ? 259 VAL B CG1 1 
ATOM   1705 C  CG2 . VAL A 1 266 ? 178.862 189.383 140.479 1.00 98.70  ? 259 VAL B CG2 1 
ATOM   1706 N  N   . LEU A 1 267 ? 180.456 191.472 144.259 1.00 102.66 ? 260 LEU B N   1 
ATOM   1707 C  CA  . LEU A 1 267 ? 181.433 191.910 145.250 1.00 101.21 ? 260 LEU B CA  1 
ATOM   1708 C  C   . LEU A 1 267 ? 181.156 191.283 146.608 1.00 100.04 ? 260 LEU B C   1 
ATOM   1709 O  O   . LEU A 1 267 ? 182.088 190.903 147.325 1.00 99.23  ? 260 LEU B O   1 
ATOM   1710 C  CB  . LEU A 1 267 ? 181.435 193.432 145.357 1.00 100.80 ? 260 LEU B CB  1 
ATOM   1711 C  CG  . LEU A 1 267 ? 182.647 194.112 144.727 1.00 94.75  ? 260 LEU B CG  1 
ATOM   1712 C  CD1 . LEU A 1 267 ? 183.901 193.782 145.511 1.00 88.04  ? 260 LEU B CD1 1 
ATOM   1713 C  CD2 . LEU A 1 267 ? 182.790 193.673 143.292 1.00 94.06  ? 260 LEU B CD2 1 
ATOM   1714 N  N   . HIS A 1 268 ? 179.881 191.169 146.980 1.00 102.11 ? 261 HIS B N   1 
ATOM   1715 C  CA  . HIS A 1 268 ? 179.534 190.519 148.239 1.00 105.16 ? 261 HIS B CA  1 
ATOM   1716 C  C   . HIS A 1 268 ? 180.009 189.072 148.256 1.00 103.25 ? 261 HIS B C   1 
ATOM   1717 O  O   . HIS A 1 268 ? 180.609 188.618 149.237 1.00 100.66 ? 261 HIS B O   1 
ATOM   1718 C  CB  . HIS A 1 268 ? 178.023 190.601 148.456 1.00 105.23 ? 261 HIS B CB  1 
ATOM   1719 C  CG  . HIS A 1 268 ? 177.544 189.906 149.692 1.00 102.36 ? 261 HIS B CG  1 
ATOM   1720 N  ND1 . HIS A 1 268 ? 177.364 188.541 149.756 1.00 104.56 ? 261 HIS B ND1 1 
ATOM   1721 C  CD2 . HIS A 1 268 ? 177.196 190.389 150.907 1.00 99.09  ? 261 HIS B CD2 1 
ATOM   1722 C  CE1 . HIS A 1 268 ? 176.932 188.213 150.960 1.00 105.50 ? 261 HIS B CE1 1 
ATOM   1723 N  NE2 . HIS A 1 268 ? 176.822 189.316 151.678 1.00 103.71 ? 261 HIS B NE2 1 
ATOM   1724 N  N   . GLN A 1 269 ? 179.766 188.340 147.168 1.00 101.67 ? 262 GLN B N   1 
ATOM   1725 C  CA  . GLN A 1 269 ? 180.181 186.943 147.106 1.00 96.86  ? 262 GLN B CA  1 
ATOM   1726 C  C   . GLN A 1 269 ? 181.696 186.815 147.162 1.00 97.09  ? 262 GLN B C   1 
ATOM   1727 O  O   . GLN A 1 269 ? 182.225 185.928 147.840 1.00 99.45  ? 262 GLN B O   1 
ATOM   1728 C  CB  . GLN A 1 269 ? 179.640 186.288 145.836 1.00 96.14  ? 262 GLN B CB  1 
ATOM   1729 C  CG  . GLN A 1 269 ? 178.135 186.138 145.803 1.00 96.37  ? 262 GLN B CG  1 
ATOM   1730 C  CD  . GLN A 1 269 ? 177.602 185.365 146.985 1.00 99.84  ? 262 GLN B CD  1 
ATOM   1731 O  OE1 . GLN A 1 269 ? 178.236 184.427 147.467 1.00 100.38 ? 262 GLN B OE1 1 
ATOM   1732 N  NE2 . GLN A 1 269 ? 176.425 185.752 147.458 1.00 103.34 ? 262 GLN B NE2 1 
ATOM   1733 N  N   . VAL A 1 270 ? 182.410 187.689 146.451 1.00 96.75  ? 263 VAL B N   1 
ATOM   1734 C  CA  . VAL A 1 270 ? 183.869 187.651 146.485 1.00 93.83  ? 263 VAL B CA  1 
ATOM   1735 C  C   . VAL A 1 270 ? 184.372 187.940 147.891 1.00 94.87  ? 263 VAL B C   1 
ATOM   1736 O  O   . VAL A 1 270 ? 185.324 187.313 148.370 1.00 92.38  ? 263 VAL B O   1 
ATOM   1737 C  CB  . VAL A 1 270 ? 184.455 188.636 145.457 1.00 89.12  ? 263 VAL B CB  1 
ATOM   1738 C  CG1 . VAL A 1 270 ? 185.866 189.043 145.842 1.00 79.82  ? 263 VAL B CG1 1 
ATOM   1739 C  CG2 . VAL A 1 270 ? 184.438 188.019 144.073 1.00 87.03  ? 263 VAL B CG2 1 
ATOM   1740 N  N   . ASN A 1 271 ? 183.732 188.885 148.581 1.00 98.31  ? 264 ASN B N   1 
ATOM   1741 C  CA  . ASN A 1 271 ? 184.153 189.235 149.931 1.00 101.16 ? 264 ASN B CA  1 
ATOM   1742 C  C   . ASN A 1 271 ? 183.821 188.142 150.936 1.00 100.77 ? 264 ASN B C   1 
ATOM   1743 O  O   . ASN A 1 271 ? 184.480 188.045 151.978 1.00 99.78  ? 264 ASN B O   1 
ATOM   1744 C  CB  . ASN A 1 271 ? 183.501 190.549 150.348 1.00 104.37 ? 264 ASN B CB  1 
ATOM   1745 C  CG  . ASN A 1 271 ? 184.070 191.096 151.632 1.00 112.35 ? 264 ASN B CG  1 
ATOM   1746 O  OD1 . ASN A 1 271 ? 185.252 190.919 151.928 1.00 109.36 ? 264 ASN B OD1 1 
ATOM   1747 N  ND2 . ASN A 1 271 ? 183.231 191.769 152.406 1.00 120.32 ? 264 ASN B ND2 1 
ATOM   1748 N  N   . GLN A 1 272 ? 182.807 187.319 150.652 1.00 100.04 ? 265 GLN B N   1 
ATOM   1749 C  CA  . GLN A 1 272 ? 182.404 186.287 151.604 1.00 98.40  ? 265 GLN B CA  1 
ATOM   1750 C  C   . GLN A 1 272 ? 183.528 185.290 151.855 1.00 96.04  ? 265 GLN B C   1 
ATOM   1751 O  O   . GLN A 1 272 ? 183.773 184.896 153.000 1.00 92.59  ? 265 GLN B O   1 
ATOM   1752 C  CB  . GLN A 1 272 ? 181.155 185.564 151.104 1.00 100.67 ? 265 GLN B CB  1 
ATOM   1753 C  CG  . GLN A 1 272 ? 179.863 186.324 151.342 1.00 102.87 ? 265 GLN B CG  1 
ATOM   1754 C  CD  . GLN A 1 272 ? 179.297 186.107 152.727 1.00 105.89 ? 265 GLN B CD  1 
ATOM   1755 O  OE1 . GLN A 1 272 ? 179.981 186.308 153.730 1.00 106.45 ? 265 GLN B OE1 1 
ATOM   1756 N  NE2 . GLN A 1 272 ? 178.036 185.701 152.792 1.00 106.97 ? 265 GLN B NE2 1 
ATOM   1757 N  N   . SER A 1 273 ? 184.216 184.866 150.801 1.00 95.86  ? 266 SER B N   1 
ATOM   1758 C  CA  . SER A 1 273 ? 185.356 183.978 150.956 1.00 90.80  ? 266 SER B CA  1 
ATOM   1759 C  C   . SER A 1 273 ? 186.614 184.777 151.277 1.00 90.07  ? 266 SER B C   1 
ATOM   1760 O  O   . SER A 1 273 ? 186.767 185.930 150.868 1.00 91.29  ? 266 SER B O   1 
ATOM   1761 C  CB  . SER A 1 273 ? 185.561 183.147 149.692 1.00 84.39  ? 266 SER B CB  1 
ATOM   1762 O  OG  . SER A 1 273 ? 185.383 183.937 148.532 1.00 84.31  ? 266 SER B OG  1 
ATOM   1763 N  N   . SER A 1 274 ? 187.520 184.151 152.029 1.00 89.00  ? 267 SER B N   1 
ATOM   1764 C  CA  . SER A 1 274 ? 188.744 184.810 152.487 1.00 87.20  ? 267 SER B CA  1 
ATOM   1765 C  C   . SER A 1 274 ? 189.812 184.712 151.398 1.00 82.63  ? 267 SER B C   1 
ATOM   1766 O  O   . SER A 1 274 ? 190.862 184.087 151.551 1.00 79.16  ? 267 SER B O   1 
ATOM   1767 C  CB  . SER A 1 274 ? 189.221 184.191 153.792 1.00 94.46  ? 267 SER B CB  1 
ATOM   1768 O  OG  . SER A 1 274 ? 189.467 182.803 153.640 1.00 98.57  ? 267 SER B OG  1 
ATOM   1769 N  N   . VAL A 1 275 ? 189.530 185.374 150.281 1.00 79.63  ? 268 VAL B N   1 
ATOM   1770 C  CA  . VAL A 1 275 ? 190.336 185.273 149.072 1.00 75.87  ? 268 VAL B CA  1 
ATOM   1771 C  C   . VAL A 1 275 ? 191.004 186.615 148.815 1.00 76.60  ? 268 VAL B C   1 
ATOM   1772 O  O   . VAL A 1 275 ? 190.328 187.646 148.721 1.00 79.82  ? 268 VAL B O   1 
ATOM   1773 C  CB  . VAL A 1 275 ? 189.480 184.836 147.873 1.00 73.58  ? 268 VAL B CB  1 
ATOM   1774 C  CG1 . VAL A 1 275 ? 188.162 185.582 147.864 1.00 78.06  ? 268 VAL B CG1 1 
ATOM   1775 C  CG2 . VAL A 1 275 ? 190.222 185.070 146.592 1.00 69.71  ? 268 VAL B CG2 1 
ATOM   1776 N  N   . GLN A 1 276 ? 192.329 186.601 148.702 1.00 77.61  ? 269 GLN B N   1 
ATOM   1777 C  CA  . GLN A 1 276 ? 193.118 187.812 148.529 1.00 73.82  ? 269 GLN B CA  1 
ATOM   1778 C  C   . GLN A 1 276 ? 193.583 188.025 147.097 1.00 71.19  ? 269 GLN B C   1 
ATOM   1779 O  O   . GLN A 1 276 ? 194.223 189.040 146.813 1.00 74.72  ? 269 GLN B O   1 
ATOM   1780 C  CB  . GLN A 1 276 ? 194.331 187.785 149.462 1.00 72.61  ? 269 GLN B CB  1 
ATOM   1781 C  CG  . GLN A 1 276 ? 194.827 189.154 149.875 1.00 77.93  ? 269 GLN B CG  1 
ATOM   1782 C  CD  . GLN A 1 276 ? 194.219 189.625 151.175 1.00 87.84  ? 269 GLN B CD  1 
ATOM   1783 O  OE1 . GLN A 1 276 ? 193.083 189.286 151.501 1.00 88.96  ? 269 GLN B OE1 1 
ATOM   1784 N  NE2 . GLN A 1 276 ? 194.975 190.412 151.929 1.00 95.22  ? 269 GLN B NE2 1 
ATOM   1785 N  N   . VAL A 1 277 ? 193.290 187.097 146.193 1.00 66.78  ? 270 VAL B N   1 
ATOM   1786 C  CA  . VAL A 1 277 ? 193.659 187.214 144.789 1.00 65.72  ? 270 VAL B CA  1 
ATOM   1787 C  C   . VAL A 1 277 ? 192.391 187.134 143.959 1.00 67.57  ? 270 VAL B C   1 
ATOM   1788 O  O   . VAL A 1 277 ? 191.625 186.175 144.086 1.00 77.44  ? 270 VAL B O   1 
ATOM   1789 C  CB  . VAL A 1 277 ? 194.645 186.112 144.369 1.00 66.10  ? 270 VAL B CB  1 
ATOM   1790 C  CG1 . VAL A 1 277 ? 195.224 186.428 143.014 1.00 67.42  ? 270 VAL B CG1 1 
ATOM   1791 C  CG2 . VAL A 1 277 ? 195.737 185.957 145.403 1.00 68.95  ? 270 VAL B CG2 1 
ATOM   1792 N  N   . VAL A 1 278 ? 192.164 188.131 143.114 1.00 60.79  ? 271 VAL B N   1 
ATOM   1793 C  CA  . VAL A 1 278 ? 190.994 188.155 142.248 1.00 60.23  ? 271 VAL B CA  1 
ATOM   1794 C  C   . VAL A 1 278 ? 191.457 188.370 140.819 1.00 64.20  ? 271 VAL B C   1 
ATOM   1795 O  O   . VAL A 1 278 ? 192.152 189.348 140.531 1.00 69.39  ? 271 VAL B O   1 
ATOM   1796 C  CB  . VAL A 1 278 ? 189.996 189.251 142.656 1.00 64.22  ? 271 VAL B CB  1 
ATOM   1797 C  CG1 . VAL A 1 278 ? 188.826 189.257 141.706 1.00 66.89  ? 271 VAL B CG1 1 
ATOM   1798 C  CG2 . VAL A 1 278 ? 189.517 189.025 144.069 1.00 68.60  ? 271 VAL B CG2 1 
ATOM   1799 N  N   . LEU A 1 279 ? 191.066 187.469 139.927 1.00 65.69  ? 272 LEU B N   1 
ATOM   1800 C  CA  . LEU A 1 279 ? 191.402 187.569 138.513 1.00 67.68  ? 272 LEU B CA  1 
ATOM   1801 C  C   . LEU A 1 279 ? 190.220 188.209 137.798 1.00 72.04  ? 272 LEU B C   1 
ATOM   1802 O  O   . LEU A 1 279 ? 189.157 187.595 137.673 1.00 74.42  ? 272 LEU B O   1 
ATOM   1803 C  CB  . LEU A 1 279 ? 191.738 186.195 137.937 1.00 66.64  ? 272 LEU B CB  1 
ATOM   1804 C  CG  . LEU A 1 279 ? 192.155 186.078 136.469 1.00 74.45  ? 272 LEU B CG  1 
ATOM   1805 C  CD1 . LEU A 1 279 ? 193.038 184.867 136.306 1.00 75.22  ? 272 LEU B CD1 1 
ATOM   1806 C  CD2 . LEU A 1 279 ? 190.963 185.957 135.537 1.00 74.84  ? 272 LEU B CD2 1 
ATOM   1807 N  N   . LEU A 1 280 ? 190.404 189.443 137.335 1.00 70.86  ? 273 LEU B N   1 
ATOM   1808 C  CA  . LEU A 1 280 ? 189.332 190.204 136.698 1.00 70.48  ? 273 LEU B CA  1 
ATOM   1809 C  C   . LEU A 1 280 ? 189.560 190.198 135.190 1.00 69.78  ? 273 LEU B C   1 
ATOM   1810 O  O   . LEU A 1 280 ? 190.122 191.123 134.609 1.00 70.54  ? 273 LEU B O   1 
ATOM   1811 C  CB  . LEU A 1 280 ? 189.276 191.616 137.260 1.00 71.36  ? 273 LEU B CB  1 
ATOM   1812 C  CG  . LEU A 1 280 ? 188.094 192.473 136.823 1.00 68.77  ? 273 LEU B CG  1 
ATOM   1813 C  CD1 . LEU A 1 280 ? 186.812 191.688 136.926 1.00 70.16  ? 273 LEU B CD1 1 
ATOM   1814 C  CD2 . LEU A 1 280 ? 188.025 193.711 137.681 1.00 70.83  ? 273 LEU B CD2 1 
ATOM   1815 N  N   . PHE A 1 281 ? 189.104 189.122 134.551 1.00 73.32  ? 274 PHE B N   1 
ATOM   1816 C  CA  . PHE A 1 281 ? 189.188 188.986 133.099 1.00 79.01  ? 274 PHE B CA  1 
ATOM   1817 C  C   . PHE A 1 281 ? 187.974 189.670 132.485 1.00 79.28  ? 274 PHE B C   1 
ATOM   1818 O  O   . PHE A 1 281 ? 187.001 189.037 132.074 1.00 84.95  ? 274 PHE B O   1 
ATOM   1819 C  CB  . PHE A 1 281 ? 189.269 187.518 132.702 1.00 78.98  ? 274 PHE B CB  1 
ATOM   1820 C  CG  . PHE A 1 281 ? 189.747 187.301 131.302 1.00 79.06  ? 274 PHE B CG  1 
ATOM   1821 C  CD1 . PHE A 1 281 ? 191.097 187.207 131.025 1.00 79.16  ? 274 PHE B CD1 1 
ATOM   1822 C  CD2 . PHE A 1 281 ? 188.849 187.197 130.260 1.00 80.21  ? 274 PHE B CD2 1 
ATOM   1823 C  CE1 . PHE A 1 281 ? 191.540 187.011 129.738 1.00 80.13  ? 274 PHE B CE1 1 
ATOM   1824 C  CE2 . PHE A 1 281 ? 189.289 187.001 128.972 1.00 83.33  ? 274 PHE B CE2 1 
ATOM   1825 C  CZ  . PHE A 1 281 ? 190.635 186.908 128.711 1.00 82.30  ? 274 PHE B CZ  1 
ATOM   1826 N  N   . ALA A 1 282 ? 188.040 190.996 132.417 1.00 73.23  ? 275 ALA B N   1 
ATOM   1827 C  CA  . ALA A 1 282 ? 186.911 191.800 131.983 1.00 75.75  ? 275 ALA B CA  1 
ATOM   1828 C  C   . ALA A 1 282 ? 187.358 192.843 130.972 1.00 79.39  ? 275 ALA B C   1 
ATOM   1829 O  O   . ALA A 1 282 ? 188.535 193.193 130.885 1.00 82.21  ? 275 ALA B O   1 
ATOM   1830 C  CB  . ALA A 1 282 ? 186.232 192.489 133.171 1.00 80.46  ? 275 ALA B CB  1 
ATOM   1831 N  N   . SER A 1 283 ? 186.391 193.340 130.204 1.00 83.11  ? 276 SER B N   1 
ATOM   1832 C  CA  . SER A 1 283 ? 186.635 194.446 129.294 1.00 83.59  ? 276 SER B CA  1 
ATOM   1833 C  C   . SER A 1 283 ? 186.885 195.723 130.090 1.00 84.01  ? 276 SER B C   1 
ATOM   1834 O  O   . SER A 1 283 ? 186.854 195.739 131.322 1.00 88.25  ? 276 SER B O   1 
ATOM   1835 C  CB  . SER A 1 283 ? 185.455 194.622 128.344 1.00 84.55  ? 276 SER B CB  1 
ATOM   1836 O  OG  . SER A 1 283 ? 184.893 193.371 127.992 1.00 90.77  ? 276 SER B OG  1 
ATOM   1837 N  N   . VAL A 1 284 ? 187.138 196.817 129.373 1.00 82.94  ? 277 VAL B N   1 
ATOM   1838 C  CA  . VAL A 1 284 ? 187.462 198.072 130.042 1.00 81.80  ? 277 VAL B CA  1 
ATOM   1839 C  C   . VAL A 1 284 ? 186.265 198.587 130.828 1.00 82.70  ? 277 VAL B C   1 
ATOM   1840 O  O   . VAL A 1 284 ? 186.399 199.027 131.974 1.00 82.58  ? 277 VAL B O   1 
ATOM   1841 C  CB  . VAL A 1 284 ? 187.955 199.115 129.026 1.00 78.59  ? 277 VAL B CB  1 
ATOM   1842 C  CG1 . VAL A 1 284 ? 188.772 200.180 129.730 1.00 75.62  ? 277 VAL B CG1 1 
ATOM   1843 C  CG2 . VAL A 1 284 ? 188.769 198.445 127.939 1.00 79.73  ? 277 VAL B CG2 1 
ATOM   1844 N  N   . HIS A 1 285 ? 185.079 198.545 130.224 1.00 82.92  ? 278 HIS B N   1 
ATOM   1845 C  CA  . HIS A 1 285 ? 183.910 199.145 130.858 1.00 82.01  ? 278 HIS B CA  1 
ATOM   1846 C  C   . HIS A 1 285 ? 183.506 198.386 132.115 1.00 84.59  ? 278 HIS B C   1 
ATOM   1847 O  O   . HIS A 1 285 ? 183.203 198.996 133.146 1.00 88.84  ? 278 HIS B O   1 
ATOM   1848 C  CB  . HIS A 1 285 ? 182.756 199.213 129.860 1.00 84.20  ? 278 HIS B CB  1 
ATOM   1849 C  CG  . HIS A 1 285 ? 183.065 200.032 128.649 1.00 87.14  ? 278 HIS B CG  1 
ATOM   1850 N  ND1 . HIS A 1 285 ? 183.713 201.246 128.721 1.00 85.54  ? 278 HIS B ND1 1 
ATOM   1851 C  CD2 . HIS A 1 285 ? 182.833 199.808 127.334 1.00 86.59  ? 278 HIS B CD2 1 
ATOM   1852 C  CE1 . HIS A 1 285 ? 183.860 201.738 127.504 1.00 84.70  ? 278 HIS B CE1 1 
ATOM   1853 N  NE2 . HIS A 1 285 ? 183.335 200.884 126.644 1.00 86.43  ? 278 HIS B NE2 1 
ATOM   1854 N  N   . ALA A 1 286 ? 183.500 197.053 132.053 1.00 82.36  ? 279 ALA B N   1 
ATOM   1855 C  CA  . ALA A 1 286 ? 183.139 196.270 133.230 1.00 81.59  ? 279 ALA B CA  1 
ATOM   1856 C  C   . ALA A 1 286 ? 184.147 196.465 134.356 1.00 83.57  ? 279 ALA B C   1 
ATOM   1857 O  O   . ALA A 1 286 ? 183.764 196.620 135.522 1.00 83.45  ? 279 ALA B O   1 
ATOM   1858 C  CB  . ALA A 1 286 ? 183.025 194.794 132.863 1.00 79.95  ? 279 ALA B CB  1 
ATOM   1859 N  N   . ALA A 1 287 ? 185.440 196.463 134.026 1.00 81.73  ? 280 ALA B N   1 
ATOM   1860 C  CA  . ALA A 1 287 ? 186.466 196.664 135.043 1.00 76.70  ? 280 ALA B CA  1 
ATOM   1861 C  C   . ALA A 1 287 ? 186.353 198.042 135.676 1.00 79.92  ? 280 ALA B C   1 
ATOM   1862 O  O   . ALA A 1 287 ? 186.431 198.179 136.903 1.00 83.11  ? 280 ALA B O   1 
ATOM   1863 C  CB  . ALA A 1 287 ? 187.851 196.469 134.434 1.00 74.34  ? 280 ALA B CB  1 
ATOM   1864 N  N   . HIS A 1 288 ? 186.159 199.076 134.857 1.00 80.68  ? 281 HIS B N   1 
ATOM   1865 C  CA  . HIS A 1 288 ? 186.018 200.423 135.394 1.00 84.90  ? 281 HIS B CA  1 
ATOM   1866 C  C   . HIS A 1 288 ? 184.785 200.541 136.278 1.00 88.22  ? 281 HIS B C   1 
ATOM   1867 O  O   . HIS A 1 288 ? 184.837 201.168 137.341 1.00 91.91  ? 281 HIS B O   1 
ATOM   1868 C  CB  . HIS A 1 288 ? 185.952 201.441 134.261 1.00 87.58  ? 281 HIS B CB  1 
ATOM   1869 C  CG  . HIS A 1 288 ? 185.209 202.687 134.622 1.00 91.88  ? 281 HIS B CG  1 
ATOM   1870 N  ND1 . HIS A 1 288 ? 185.612 203.522 135.640 1.00 96.21  ? 281 HIS B ND1 1 
ATOM   1871 C  CD2 . HIS A 1 288 ? 184.084 203.235 134.108 1.00 93.11  ? 281 HIS B CD2 1 
ATOM   1872 C  CE1 . HIS A 1 288 ? 184.770 204.535 135.735 1.00 98.25  ? 281 HIS B CE1 1 
ATOM   1873 N  NE2 . HIS A 1 288 ? 183.833 204.385 134.816 1.00 98.18  ? 281 HIS B NE2 1 
ATOM   1874 N  N   . ALA A 1 289 ? 183.662 199.956 135.854 1.00 87.65  ? 282 ALA B N   1 
ATOM   1875 C  CA  . ALA A 1 289 ? 182.449 200.028 136.661 1.00 87.60  ? 282 ALA B CA  1 
ATOM   1876 C  C   . ALA A 1 289 ? 182.628 199.311 137.992 1.00 86.60  ? 282 ALA B C   1 
ATOM   1877 O  O   . ALA A 1 289 ? 182.217 199.823 139.042 1.00 93.51  ? 282 ALA B O   1 
ATOM   1878 C  CB  . ALA A 1 289 ? 181.270 199.438 135.890 1.00 87.96  ? 282 ALA B CB  1 
ATOM   1879 N  N   . LEU A 1 290 ? 183.242 198.126 137.969 1.00 79.93  ? 283 LEU B N   1 
ATOM   1880 C  CA  . LEU A 1 290 ? 183.476 197.403 139.212 1.00 80.02  ? 283 LEU B CA  1 
ATOM   1881 C  C   . LEU A 1 290 ? 184.377 198.196 140.143 1.00 83.20  ? 283 LEU B C   1 
ATOM   1882 O  O   . LEU A 1 290 ? 184.122 198.272 141.349 1.00 86.65  ? 283 LEU B O   1 
ATOM   1883 C  CB  . LEU A 1 290 ? 184.086 196.034 138.924 1.00 77.95  ? 283 LEU B CB  1 
ATOM   1884 C  CG  . LEU A 1 290 ? 184.533 195.246 140.155 1.00 75.45  ? 283 LEU B CG  1 
ATOM   1885 C  CD1 . LEU A 1 290 ? 184.129 193.805 140.009 1.00 81.86  ? 283 LEU B CD1 1 
ATOM   1886 C  CD2 . LEU A 1 290 ? 186.030 195.342 140.362 1.00 75.38  ? 283 LEU B CD2 1 
ATOM   1887 N  N   . PHE A 1 291 ? 185.445 198.787 139.605 1.00 83.17  ? 284 PHE B N   1 
ATOM   1888 C  CA  . PHE A 1 291 ? 186.357 199.542 140.454 1.00 82.22  ? 284 PHE B CA  1 
ATOM   1889 C  C   . PHE A 1 291 ? 185.684 200.783 141.019 1.00 86.38  ? 284 PHE B C   1 
ATOM   1890 O  O   . PHE A 1 291 ? 185.895 201.129 142.184 1.00 88.61  ? 284 PHE B O   1 
ATOM   1891 C  CB  . PHE A 1 291 ? 187.616 199.905 139.677 1.00 78.44  ? 284 PHE B CB  1 
ATOM   1892 C  CG  . PHE A 1 291 ? 188.530 198.743 139.457 1.00 75.23  ? 284 PHE B CG  1 
ATOM   1893 C  CD1 . PHE A 1 291 ? 188.635 197.750 140.405 1.00 73.03  ? 284 PHE B CD1 1 
ATOM   1894 C  CD2 . PHE A 1 291 ? 189.266 198.631 138.301 1.00 79.41  ? 284 PHE B CD2 1 
ATOM   1895 C  CE1 . PHE A 1 291 ? 189.465 196.675 140.206 1.00 72.86  ? 284 PHE B CE1 1 
ATOM   1896 C  CE2 . PHE A 1 291 ? 190.099 197.557 138.099 1.00 77.73  ? 284 PHE B CE2 1 
ATOM   1897 C  CZ  . PHE A 1 291 ? 190.198 196.579 139.051 1.00 72.84  ? 284 PHE B CZ  1 
ATOM   1898 N  N   . ASN A 1 292 ? 184.860 201.459 140.219 1.00 89.05  ? 285 ASN B N   1 
ATOM   1899 C  CA  . ASN A 1 292 ? 184.142 202.624 140.721 1.00 90.76  ? 285 ASN B CA  1 
ATOM   1900 C  C   . ASN A 1 292 ? 183.204 202.238 141.858 1.00 95.09  ? 285 ASN B C   1 
ATOM   1901 O  O   . ASN A 1 292 ? 183.186 202.886 142.913 1.00 96.50  ? 285 ASN B O   1 
ATOM   1902 C  CB  . ASN A 1 292 ? 183.369 203.289 139.584 1.00 90.81  ? 285 ASN B CB  1 
ATOM   1903 C  CG  . ASN A 1 292 ? 182.454 204.387 140.070 1.00 99.76  ? 285 ASN B CG  1 
ATOM   1904 O  OD1 . ASN A 1 292 ? 182.898 205.497 140.359 1.00 104.21 ? 285 ASN B OD1 1 
ATOM   1905 N  ND2 . ASN A 1 292 ? 181.166 204.085 140.167 1.00 104.24 ? 285 ASN B ND2 1 
ATOM   1906 N  N   . TYR A 1 293 ? 182.427 201.166 141.669 1.00 96.88  ? 286 TYR B N   1 
ATOM   1907 C  CA  . TYR A 1 293 ? 181.507 200.749 142.723 1.00 96.75  ? 286 TYR B CA  1 
ATOM   1908 C  C   . TYR A 1 293 ? 182.256 200.319 143.977 1.00 95.69  ? 286 TYR B C   1 
ATOM   1909 O  O   . TYR A 1 293 ? 181.849 200.655 145.094 1.00 98.91  ? 286 TYR B O   1 
ATOM   1910 C  CB  . TYR A 1 293 ? 180.607 199.616 142.246 1.00 93.91  ? 286 TYR B CB  1 
ATOM   1911 C  CG  . TYR A 1 293 ? 180.045 198.821 143.399 1.00 97.36  ? 286 TYR B CG  1 
ATOM   1912 C  CD1 . TYR A 1 293 ? 179.140 199.392 144.280 1.00 100.20 ? 286 TYR B CD1 1 
ATOM   1913 C  CD2 . TYR A 1 293 ? 180.432 197.509 143.619 1.00 97.85  ? 286 TYR B CD2 1 
ATOM   1914 C  CE1 . TYR A 1 293 ? 178.631 198.679 145.340 1.00 102.70 ? 286 TYR B CE1 1 
ATOM   1915 C  CE2 . TYR A 1 293 ? 179.924 196.785 144.676 1.00 99.80  ? 286 TYR B CE2 1 
ATOM   1916 C  CZ  . TYR A 1 293 ? 179.024 197.375 145.534 1.00 103.91 ? 286 TYR B CZ  1 
ATOM   1917 O  OH  . TYR A 1 293 ? 178.512 196.659 146.591 1.00 105.82 ? 286 TYR B OH  1 
ATOM   1918 N  N   . SER A 1 294 ? 183.347 199.568 143.818 1.00 91.71  ? 287 SER B N   1 
ATOM   1919 C  CA  . SER A 1 294 ? 184.103 199.134 144.986 1.00 90.89  ? 287 SER B CA  1 
ATOM   1920 C  C   . SER A 1 294 ? 184.755 200.312 145.694 1.00 90.83  ? 287 SER B C   1 
ATOM   1921 O  O   . SER A 1 294 ? 184.943 200.271 146.913 1.00 95.46  ? 287 SER B O   1 
ATOM   1922 C  CB  . SER A 1 294 ? 185.156 198.108 144.584 1.00 88.72  ? 287 SER B CB  1 
ATOM   1923 O  OG  . SER A 1 294 ? 185.903 198.565 143.475 1.00 89.46  ? 287 SER B OG  1 
ATOM   1924 N  N   . ILE A 1 295 ? 185.120 201.358 144.953 1.00 87.16  ? 288 ILE B N   1 
ATOM   1925 C  CA  . ILE A 1 295 ? 185.588 202.580 145.596 1.00 88.94  ? 288 ILE B CA  1 
ATOM   1926 C  C   . ILE A 1 295 ? 184.466 203.196 146.415 1.00 93.32  ? 288 ILE B C   1 
ATOM   1927 O  O   . ILE A 1 295 ? 184.674 203.636 147.552 1.00 94.87  ? 288 ILE B O   1 
ATOM   1928 C  CB  . ILE A 1 295 ? 186.139 203.562 144.547 1.00 86.93  ? 288 ILE B CB  1 
ATOM   1929 C  CG1 . ILE A 1 295 ? 187.549 203.151 144.125 1.00 85.93  ? 288 ILE B CG1 1 
ATOM   1930 C  CG2 . ILE A 1 295 ? 186.139 204.979 145.088 1.00 85.97  ? 288 ILE B CG2 1 
ATOM   1931 C  CD1 . ILE A 1 295 ? 188.290 204.198 143.349 1.00 86.40  ? 288 ILE B CD1 1 
ATOM   1932 N  N   . SER A 1 296 ? 183.253 203.220 145.858 1.00 94.73  ? 289 SER B N   1 
ATOM   1933 C  CA  . SER A 1 296 ? 182.126 203.783 146.593 1.00 98.27  ? 289 SER B CA  1 
ATOM   1934 C  C   . SER A 1 296 ? 181.861 203.029 147.890 1.00 97.48  ? 289 SER B C   1 
ATOM   1935 O  O   . SER A 1 296 ? 181.449 203.635 148.883 1.00 97.94  ? 289 SER B O   1 
ATOM   1936 C  CB  . SER A 1 296 ? 180.873 203.784 145.718 1.00 102.18 ? 289 SER B CB  1 
ATOM   1937 O  OG  . SER A 1 296 ? 180.017 202.708 146.056 1.00 104.64 ? 289 SER B OG  1 
ATOM   1938 N  N   . SER A 1 297 ? 182.092 201.719 147.907 1.00 96.35  ? 290 SER B N   1 
ATOM   1939 C  CA  . SER A 1 297 ? 181.848 200.905 149.092 1.00 94.72  ? 290 SER B CA  1 
ATOM   1940 C  C   . SER A 1 297 ? 183.087 200.717 149.957 1.00 95.39  ? 290 SER B C   1 
ATOM   1941 O  O   . SER A 1 297 ? 183.006 200.029 150.979 1.00 93.26  ? 290 SER B O   1 
ATOM   1942 C  CB  . SER A 1 297 ? 181.299 199.535 148.689 1.00 93.49  ? 290 SER B CB  1 
ATOM   1943 O  OG  . SER A 1 297 ? 179.910 199.604 148.419 1.00 94.85  ? 290 SER B OG  1 
ATOM   1944 N  N   . ARG A 1 298 ? 184.219 201.307 149.573 1.00 96.46  ? 291 ARG B N   1 
ATOM   1945 C  CA  . ARG A 1 298 ? 185.471 201.212 150.324 1.00 96.33  ? 291 ARG B CA  1 
ATOM   1946 C  C   . ARG A 1 298 ? 185.868 199.752 150.559 1.00 95.47  ? 291 ARG B C   1 
ATOM   1947 O  O   . ARG A 1 298 ? 185.975 199.278 151.691 1.00 96.25  ? 291 ARG B O   1 
ATOM   1948 C  CB  . ARG A 1 298 ? 185.375 201.981 151.643 1.00 97.80  ? 291 ARG B CB  1 
ATOM   1949 C  CG  . ARG A 1 298 ? 185.930 203.393 151.573 1.00 95.16  ? 291 ARG B CG  1 
ATOM   1950 C  CD  . ARG A 1 298 ? 186.630 203.770 152.869 1.00 99.73  ? 291 ARG B CD  1 
ATOM   1951 N  NE  . ARG A 1 298 ? 187.700 202.836 153.198 1.00 106.02 ? 291 ARG B NE  1 
ATOM   1952 C  CZ  . ARG A 1 298 ? 187.643 201.948 154.181 1.00 99.04  ? 291 ARG B CZ  1 
ATOM   1953 N  NH1 . ARG A 1 298 ? 186.583 201.853 154.965 1.00 93.24  ? 291 ARG B NH1 1 
ATOM   1954 N  NH2 . ARG A 1 298 ? 188.676 201.134 154.381 1.00 94.87  ? 291 ARG B NH2 1 
ATOM   1955 N  N   . LEU A 1 299 ? 186.082 199.044 149.456 1.00 92.07  ? 292 LEU B N   1 
ATOM   1956 C  CA  . LEU A 1 299 ? 186.500 197.653 149.521 1.00 87.34  ? 292 LEU B CA  1 
ATOM   1957 C  C   . LEU A 1 299 ? 187.952 197.546 149.973 1.00 86.94  ? 292 LEU B C   1 
ATOM   1958 O  O   . LEU A 1 299 ? 188.778 198.420 149.700 1.00 87.27  ? 292 LEU B O   1 
ATOM   1959 C  CB  . LEU A 1 299 ? 186.315 196.985 148.160 1.00 88.05  ? 292 LEU B CB  1 
ATOM   1960 C  CG  . LEU A 1 299 ? 186.899 195.590 147.943 1.00 87.47  ? 292 LEU B CG  1 
ATOM   1961 C  CD1 . LEU A 1 299 ? 185.938 194.528 148.437 1.00 87.43  ? 292 LEU B CD1 1 
ATOM   1962 C  CD2 . LEU A 1 299 ? 187.226 195.374 146.477 1.00 85.94  ? 292 LEU B CD2 1 
ATOM   1963 N  N   . SER A 1 300 ? 188.254 196.464 150.686 1.00 90.45  ? 293 SER B N   1 
ATOM   1964 C  CA  . SER A 1 300 ? 189.609 196.219 151.149 1.00 89.00  ? 293 SER B CA  1 
ATOM   1965 C  C   . SER A 1 300 ? 190.532 195.927 149.966 1.00 85.67  ? 293 SER B C   1 
ATOM   1966 O  O   . SER A 1 300 ? 190.073 195.510 148.901 1.00 83.28  ? 293 SER B O   1 
ATOM   1967 C  CB  . SER A 1 300 ? 189.630 195.048 152.127 1.00 85.24  ? 293 SER B CB  1 
ATOM   1968 O  OG  . SER A 1 300 ? 188.994 193.914 151.570 1.00 86.44  ? 293 SER B OG  1 
ATOM   1969 N  N   . PRO A 1 301 ? 191.834 196.163 150.119 1.00 83.01  ? 294 PRO B N   1 
ATOM   1970 C  CA  . PRO A 1 301 ? 192.760 195.881 149.020 1.00 82.64  ? 294 PRO B CA  1 
ATOM   1971 C  C   . PRO A 1 301 ? 192.820 194.396 148.695 1.00 82.67  ? 294 PRO B C   1 
ATOM   1972 O  O   . PRO A 1 301 ? 192.684 193.538 149.568 1.00 81.87  ? 294 PRO B O   1 
ATOM   1973 C  CB  . PRO A 1 301 ? 194.106 196.389 149.550 1.00 80.93  ? 294 PRO B CB  1 
ATOM   1974 C  CG  . PRO A 1 301 ? 193.956 196.397 151.023 1.00 77.40  ? 294 PRO B CG  1 
ATOM   1975 C  CD  . PRO A 1 301 ? 192.526 196.753 151.275 1.00 80.45  ? 294 PRO B CD  1 
ATOM   1976 N  N   . LYS A 1 302 ? 193.028 194.106 147.412 1.00 81.60  ? 295 LYS B N   1 
ATOM   1977 C  CA  . LYS A 1 302 ? 193.197 192.745 146.926 1.00 74.05  ? 295 LYS B CA  1 
ATOM   1978 C  C   . LYS A 1 302 ? 194.193 192.769 145.777 1.00 71.60  ? 295 LYS B C   1 
ATOM   1979 O  O   . LYS A 1 302 ? 194.468 193.820 145.195 1.00 75.35  ? 295 LYS B O   1 
ATOM   1980 C  CB  . LYS A 1 302 ? 191.867 192.134 146.473 1.00 68.81  ? 295 LYS B CB  1 
ATOM   1981 C  CG  . LYS A 1 302 ? 190.906 191.828 147.600 1.00 69.55  ? 295 LYS B CG  1 
ATOM   1982 C  CD  . LYS A 1 302 ? 189.705 191.049 147.111 1.00 67.10  ? 295 LYS B CD  1 
ATOM   1983 C  CE  . LYS A 1 302 ? 188.749 190.743 148.249 1.00 69.02  ? 295 LYS B CE  1 
ATOM   1984 N  NZ  . LYS A 1 302 ? 189.406 190.856 149.574 1.00 67.82  ? 295 LYS B NZ  1 
ATOM   1985 N  N   . VAL A 1 303 ? 194.741 191.600 145.458 1.00 67.11  ? 296 VAL B N   1 
ATOM   1986 C  CA  . VAL A 1 303 ? 195.682 191.457 144.352 1.00 67.13  ? 296 VAL B CA  1 
ATOM   1987 C  C   . VAL A 1 303 ? 194.866 191.164 143.098 1.00 69.34  ? 296 VAL B C   1 
ATOM   1988 O  O   . VAL A 1 303 ? 194.414 190.039 142.886 1.00 70.89  ? 296 VAL B O   1 
ATOM   1989 C  CB  . VAL A 1 303 ? 196.709 190.359 144.620 1.00 61.19  ? 296 VAL B CB  1 
ATOM   1990 C  CG1 . VAL A 1 303 ? 197.634 190.203 143.430 1.00 58.97  ? 296 VAL B CG1 1 
ATOM   1991 C  CG2 . VAL A 1 303 ? 197.497 190.679 145.865 1.00 68.44  ? 296 VAL B CG2 1 
ATOM   1992 N  N   . TRP A 1 304 ? 194.683 192.177 142.258 1.00 67.59  ? 297 TRP B N   1 
ATOM   1993 C  CA  . TRP A 1 304 ? 193.899 192.034 141.040 1.00 64.02  ? 297 TRP B CA  1 
ATOM   1994 C  C   . TRP A 1 304 ? 194.807 191.572 139.910 1.00 68.34  ? 297 TRP B C   1 
ATOM   1995 O  O   . TRP A 1 304 ? 195.806 192.228 139.606 1.00 73.67  ? 297 TRP B O   1 
ATOM   1996 C  CB  . TRP A 1 304 ? 193.225 193.350 140.666 1.00 61.20  ? 297 TRP B CB  1 
ATOM   1997 C  CG  . TRP A 1 304 ? 192.310 193.869 141.703 1.00 60.93  ? 297 TRP B CG  1 
ATOM   1998 C  CD1 . TRP A 1 304 ? 192.627 194.721 142.709 1.00 65.26  ? 297 TRP B CD1 1 
ATOM   1999 C  CD2 . TRP A 1 304 ? 190.919 193.575 141.848 1.00 65.12  ? 297 TRP B CD2 1 
ATOM   2000 N  NE1 . TRP A 1 304 ? 191.522 194.981 143.476 1.00 70.49  ? 297 TRP B NE1 1 
ATOM   2001 C  CE2 . TRP A 1 304 ? 190.459 194.285 142.968 1.00 68.82  ? 297 TRP B CE2 1 
ATOM   2002 C  CE3 . TRP A 1 304 ? 190.019 192.778 141.142 1.00 67.43  ? 297 TRP B CE3 1 
ATOM   2003 C  CZ2 . TRP A 1 304 ? 189.139 194.224 143.399 1.00 68.90  ? 297 TRP B CZ2 1 
ATOM   2004 C  CZ3 . TRP A 1 304 ? 188.709 192.720 141.571 1.00 69.10  ? 297 TRP B CZ3 1 
ATOM   2005 C  CH2 . TRP A 1 304 ? 188.282 193.438 142.688 1.00 67.61  ? 297 TRP B CH2 1 
ATOM   2006 N  N   . VAL A 1 305 ? 194.461 190.450 139.292 1.00 66.84  ? 298 VAL B N   1 
ATOM   2007 C  CA  . VAL A 1 305 ? 195.152 189.978 138.099 1.00 65.01  ? 298 VAL B CA  1 
ATOM   2008 C  C   . VAL A 1 305 ? 194.399 190.508 136.889 1.00 67.82  ? 298 VAL B C   1 
ATOM   2009 O  O   . VAL A 1 305 ? 193.210 190.228 136.716 1.00 68.62  ? 298 VAL B O   1 
ATOM   2010 C  CB  . VAL A 1 305 ? 195.244 188.448 138.072 1.00 62.84  ? 298 VAL B CB  1 
ATOM   2011 C  CG1 . VAL A 1 305 ? 195.833 187.989 136.762 1.00 67.67  ? 298 VAL B CG1 1 
ATOM   2012 C  CG2 . VAL A 1 305 ? 196.091 187.954 139.225 1.00 61.31  ? 298 VAL B CG2 1 
ATOM   2013 N  N   . ALA A 1 306 ? 195.092 191.269 136.049 1.00 70.21  ? 299 ALA B N   1 
ATOM   2014 C  CA  . ALA A 1 306 ? 194.467 192.040 134.985 1.00 73.00  ? 299 ALA B CA  1 
ATOM   2015 C  C   . ALA A 1 306 ? 194.697 191.391 133.629 1.00 74.48  ? 299 ALA B C   1 
ATOM   2016 O  O   . ALA A 1 306 ? 195.794 190.908 133.338 1.00 76.59  ? 299 ALA B O   1 
ATOM   2017 C  CB  . ALA A 1 306 ? 195.012 193.468 134.960 1.00 74.15  ? 299 ALA B CB  1 
ATOM   2018 N  N   . SER A 1 307 ? 193.657 191.386 132.804 1.00 71.78  ? 300 SER B N   1 
ATOM   2019 C  CA  . SER A 1 307 ? 193.813 191.006 131.413 1.00 74.82  ? 300 SER B CA  1 
ATOM   2020 C  C   . SER A 1 307 ? 194.349 192.189 130.617 1.00 80.10  ? 300 SER B C   1 
ATOM   2021 O  O   . SER A 1 307 ? 194.449 193.311 131.115 1.00 83.65  ? 300 SER B O   1 
ATOM   2022 C  CB  . SER A 1 307 ? 192.487 190.538 130.827 1.00 75.53  ? 300 SER B CB  1 
ATOM   2023 O  OG  . SER A 1 307 ? 191.743 191.640 130.344 1.00 78.26  ? 300 SER B OG  1 
ATOM   2024 N  N   . GLU A 1 308 ? 194.690 191.935 129.355 1.00 81.26  ? 301 GLU B N   1 
ATOM   2025 C  CA  . GLU A 1 308 ? 195.188 193.005 128.501 1.00 81.13  ? 301 GLU B CA  1 
ATOM   2026 C  C   . GLU A 1 308 ? 194.134 194.061 128.206 1.00 81.44  ? 301 GLU B C   1 
ATOM   2027 O  O   . GLU A 1 308 ? 194.486 195.139 127.719 1.00 80.68  ? 301 GLU B O   1 
ATOM   2028 C  CB  . GLU A 1 308 ? 195.713 192.430 127.186 1.00 82.80  ? 301 GLU B CB  1 
ATOM   2029 C  CG  . GLU A 1 308 ? 197.223 192.360 127.097 1.00 87.47  ? 301 GLU B CG  1 
ATOM   2030 C  CD  . GLU A 1 308 ? 197.711 192.086 125.689 1.00 92.07  ? 301 GLU B CD  1 
ATOM   2031 O  OE1 . GLU A 1 308 ? 197.671 190.913 125.262 1.00 89.27  ? 301 GLU B OE1 1 
ATOM   2032 O  OE2 . GLU A 1 308 ? 198.137 193.042 125.009 1.00 93.16  ? 301 GLU B OE2 1 
ATOM   2033 N  N   . ALA A 1 309 ? 192.861 193.780 128.488 1.00 82.18  ? 302 ALA B N   1 
ATOM   2034 C  CA  . ALA A 1 309 ? 191.796 194.714 128.142 1.00 79.89  ? 302 ALA B CA  1 
ATOM   2035 C  C   . ALA A 1 309 ? 191.896 195.998 128.952 1.00 78.20  ? 302 ALA B C   1 
ATOM   2036 O  O   . ALA A 1 309 ? 191.758 197.097 128.404 1.00 80.57  ? 302 ALA B O   1 
ATOM   2037 C  CB  . ALA A 1 309 ? 190.434 194.053 128.344 1.00 79.46  ? 302 ALA B CB  1 
ATOM   2038 N  N   . TRP A 1 310 ? 192.131 195.887 130.259 1.00 77.14  ? 303 TRP B N   1 
ATOM   2039 C  CA  . TRP A 1 310 ? 192.192 197.061 131.117 1.00 78.53  ? 303 TRP B CA  1 
ATOM   2040 C  C   . TRP A 1 310 ? 193.510 197.220 131.856 1.00 77.16  ? 303 TRP B C   1 
ATOM   2041 O  O   . TRP A 1 310 ? 193.631 198.139 132.670 1.00 80.01  ? 303 TRP B O   1 
ATOM   2042 C  CB  . TRP A 1 310 ? 191.045 197.048 132.135 1.00 80.40  ? 303 TRP B CB  1 
ATOM   2043 C  CG  . TRP A 1 310 ? 191.088 195.928 133.123 1.00 76.71  ? 303 TRP B CG  1 
ATOM   2044 C  CD1 . TRP A 1 310 ? 190.533 194.698 132.980 1.00 78.14  ? 303 TRP B CD1 1 
ATOM   2045 C  CD2 . TRP A 1 310 ? 191.700 195.943 134.419 1.00 74.32  ? 303 TRP B CD2 1 
ATOM   2046 N  NE1 . TRP A 1 310 ? 190.766 193.941 134.100 1.00 79.90  ? 303 TRP B NE1 1 
ATOM   2047 C  CE2 . TRP A 1 310 ? 191.481 194.685 134.998 1.00 73.03  ? 303 TRP B CE2 1 
ATOM   2048 C  CE3 . TRP A 1 310 ? 192.413 196.899 135.144 1.00 77.86  ? 303 TRP B CE3 1 
ATOM   2049 C  CZ2 . TRP A 1 310 ? 191.946 194.358 136.262 1.00 67.87  ? 303 TRP B CZ2 1 
ATOM   2050 C  CZ3 . TRP A 1 310 ? 192.877 196.568 136.397 1.00 74.58  ? 303 TRP B CZ3 1 
ATOM   2051 C  CH2 . TRP A 1 310 ? 192.642 195.312 136.943 1.00 67.90  ? 303 TRP B CH2 1 
ATOM   2052 N  N   . LEU A 1 311 ? 194.501 196.370 131.594 1.00 77.37  ? 304 LEU B N   1 
ATOM   2053 C  CA  . LEU A 1 311 ? 195.775 196.504 132.288 1.00 80.29  ? 304 LEU B CA  1 
ATOM   2054 C  C   . LEU A 1 311 ? 196.438 197.835 131.966 1.00 85.90  ? 304 LEU B C   1 
ATOM   2055 O  O   . LEU A 1 311 ? 197.024 198.473 132.847 1.00 90.01  ? 304 LEU B O   1 
ATOM   2056 C  CB  . LEU A 1 311 ? 196.701 195.347 131.925 1.00 80.71  ? 304 LEU B CB  1 
ATOM   2057 C  CG  . LEU A 1 311 ? 198.128 195.475 132.447 1.00 75.85  ? 304 LEU B CG  1 
ATOM   2058 C  CD1 . LEU A 1 311 ? 198.136 195.408 133.954 1.00 75.21  ? 304 LEU B CD1 1 
ATOM   2059 C  CD2 . LEU A 1 311 ? 198.995 194.386 131.862 1.00 75.50  ? 304 LEU B CD2 1 
ATOM   2060 N  N   . THR A 1 312 ? 196.356 198.271 130.712 1.00 83.78  ? 305 THR B N   1 
ATOM   2061 C  CA  . THR A 1 312 ? 197.001 199.502 130.283 1.00 81.81  ? 305 THR B CA  1 
ATOM   2062 C  C   . THR A 1 312 ? 196.032 200.634 129.988 1.00 90.19  ? 305 THR B C   1 
ATOM   2063 O  O   . THR A 1 312 ? 196.485 201.748 129.703 1.00 96.43  ? 305 THR B O   1 
ATOM   2064 C  CB  . THR A 1 312 ? 197.851 199.246 129.034 1.00 77.47  ? 305 THR B CB  1 
ATOM   2065 O  OG1 . THR A 1 312 ? 197.044 198.614 128.034 1.00 78.94  ? 305 THR B OG1 1 
ATOM   2066 C  CG2 . THR A 1 312 ? 199.023 198.354 129.366 1.00 83.10  ? 305 THR B CG2 1 
ATOM   2067 N  N   . SER A 1 313 ? 194.726 200.392 130.046 1.00 93.51  ? 306 SER B N   1 
ATOM   2068 C  CA  . SER A 1 313 ? 193.767 201.418 129.663 1.00 98.83  ? 306 SER B CA  1 
ATOM   2069 C  C   . SER A 1 313 ? 193.790 202.577 130.649 1.00 101.57 ? 306 SER B C   1 
ATOM   2070 O  O   . SER A 1 313 ? 193.873 202.384 131.864 1.00 96.42  ? 306 SER B O   1 
ATOM   2071 C  CB  . SER A 1 313 ? 192.360 200.832 129.577 1.00 93.59  ? 306 SER B CB  1 
ATOM   2072 O  OG  . SER A 1 313 ? 191.820 200.610 130.863 1.00 90.99  ? 306 SER B OG  1 
ATOM   2073 N  N   . ASP A 1 314 ? 193.714 203.792 130.111 1.00 105.80 ? 307 ASP B N   1 
ATOM   2074 C  CA  . ASP A 1 314 ? 193.779 205.003 130.916 1.00 108.20 ? 307 ASP B CA  1 
ATOM   2075 C  C   . ASP A 1 314 ? 192.453 205.359 131.575 1.00 107.76 ? 307 ASP B C   1 
ATOM   2076 O  O   . ASP A 1 314 ? 192.428 206.259 132.421 1.00 105.13 ? 307 ASP B O   1 
ATOM   2077 C  CB  . ASP A 1 314 ? 194.266 206.174 130.058 1.00 112.65 ? 307 ASP B CB  1 
ATOM   2078 C  CG  . ASP A 1 314 ? 193.650 206.183 128.670 1.00 114.24 ? 307 ASP B CG  1 
ATOM   2079 O  OD1 . ASP A 1 314 ? 192.497 205.729 128.516 1.00 113.38 ? 307 ASP B OD1 1 
ATOM   2080 O  OD2 . ASP A 1 314 ? 194.325 206.644 127.727 1.00 115.02 ? 307 ASP B OD2 1 
ATOM   2081 N  N   . LEU A 1 315 ? 191.357 204.695 131.205 1.00 105.54 ? 308 LEU B N   1 
ATOM   2082 C  CA  . LEU A 1 315 ? 190.094 204.919 131.898 1.00 101.65 ? 308 LEU B CA  1 
ATOM   2083 C  C   . LEU A 1 315 ? 190.175 204.454 133.346 1.00 104.38 ? 308 LEU B C   1 
ATOM   2084 O  O   . LEU A 1 315 ? 189.725 205.154 134.260 1.00 105.17 ? 308 LEU B O   1 
ATOM   2085 C  CB  . LEU A 1 315 ? 188.959 204.205 131.168 1.00 94.36  ? 308 LEU B CB  1 
ATOM   2086 C  CG  . LEU A 1 315 ? 187.630 204.175 131.922 1.00 94.48  ? 308 LEU B CG  1 
ATOM   2087 C  CD1 . LEU A 1 315 ? 187.169 205.584 132.255 1.00 96.54  ? 308 LEU B CD1 1 
ATOM   2088 C  CD2 . LEU A 1 315 ? 186.573 203.442 131.115 1.00 91.37  ? 308 LEU B CD2 1 
ATOM   2089 N  N   . VAL A 1 316 ? 190.751 203.273 133.576 1.00 103.03 ? 309 VAL B N   1 
ATOM   2090 C  CA  . VAL A 1 316 ? 190.909 202.787 134.941 1.00 100.27 ? 309 VAL B CA  1 
ATOM   2091 C  C   . VAL A 1 316 ? 192.215 203.287 135.542 1.00 105.57 ? 309 VAL B C   1 
ATOM   2092 O  O   . VAL A 1 316 ? 192.291 203.537 136.750 1.00 108.42 ? 309 VAL B O   1 
ATOM   2093 C  CB  . VAL A 1 316 ? 190.820 201.251 134.975 1.00 90.48  ? 309 VAL B CB  1 
ATOM   2094 C  CG1 . VAL A 1 316 ? 191.759 200.649 133.964 1.00 90.66  ? 309 VAL B CG1 1 
ATOM   2095 C  CG2 . VAL A 1 316 ? 191.139 200.731 136.354 1.00 89.01  ? 309 VAL B CG2 1 
ATOM   2096 N  N   . MET A 1 317 ? 193.248 203.468 134.717 1.00 104.23 ? 310 MET B N   1 
ATOM   2097 C  CA  . MET A 1 317 ? 194.528 203.948 135.225 1.00 108.00 ? 310 MET B CA  1 
ATOM   2098 C  C   . MET A 1 317 ? 194.378 205.310 135.887 1.00 109.80 ? 310 MET B C   1 
ATOM   2099 O  O   . MET A 1 317 ? 194.958 205.562 136.949 1.00 110.87 ? 310 MET B O   1 
ATOM   2100 C  CB  . MET A 1 317 ? 195.546 204.014 134.086 1.00 109.79 ? 310 MET B CB  1 
ATOM   2101 C  CG  . MET A 1 317 ? 196.996 203.998 134.532 1.00 111.24 ? 310 MET B CG  1 
ATOM   2102 S  SD  . MET A 1 317 ? 198.110 203.378 133.258 1.00 122.39 ? 310 MET B SD  1 
ATOM   2103 C  CE  . MET A 1 317 ? 198.415 201.716 133.841 1.00 98.53  ? 310 MET B CE  1 
ATOM   2104 N  N   . GLY A 1 318 ? 193.594 206.194 135.283 1.00 106.55 ? 311 GLY B N   1 
ATOM   2105 C  CA  . GLY A 1 318 ? 193.345 207.518 135.804 1.00 104.92 ? 311 GLY B CA  1 
ATOM   2106 C  C   . GLY A 1 318 ? 192.176 207.623 136.756 1.00 104.10 ? 311 GLY B C   1 
ATOM   2107 O  O   . GLY A 1 318 ? 191.781 208.739 137.106 1.00 105.00 ? 311 GLY B O   1 
ATOM   2108 N  N   . LEU A 1 319 ? 191.605 206.505 137.178 1.00 103.29 ? 312 LEU B N   1 
ATOM   2109 C  CA  . LEU A 1 319 ? 190.482 206.538 138.106 1.00 103.91 ? 312 LEU B CA  1 
ATOM   2110 C  C   . LEU A 1 319 ? 190.955 207.033 139.466 1.00 103.45 ? 312 LEU B C   1 
ATOM   2111 O  O   . LEU A 1 319 ? 191.856 206.422 140.056 1.00 100.22 ? 312 LEU B O   1 
ATOM   2112 C  CB  . LEU A 1 319 ? 189.861 205.150 138.224 1.00 101.00 ? 312 LEU B CB  1 
ATOM   2113 C  CG  . LEU A 1 319 ? 188.524 205.024 138.949 1.00 96.10  ? 312 LEU B CG  1 
ATOM   2114 C  CD1 . LEU A 1 319 ? 187.517 205.997 138.383 1.00 95.85  ? 312 LEU B CD1 1 
ATOM   2115 C  CD2 . LEU A 1 319 ? 188.010 203.608 138.832 1.00 91.88  ? 312 LEU B CD2 1 
ATOM   2116 N  N   . PRO A 1 320 ? 190.399 208.123 139.994 1.00 104.25 ? 313 PRO B N   1 
ATOM   2117 C  CA  . PRO A 1 320 ? 190.883 208.642 141.278 1.00 103.16 ? 313 PRO B CA  1 
ATOM   2118 C  C   . PRO A 1 320 ? 190.554 207.696 142.420 1.00 100.31 ? 313 PRO B C   1 
ATOM   2119 O  O   . PRO A 1 320 ? 189.462 207.129 142.487 1.00 99.82  ? 313 PRO B O   1 
ATOM   2120 C  CB  . PRO A 1 320 ? 190.142 209.976 141.424 1.00 100.03 ? 313 PRO B CB  1 
ATOM   2121 C  CG  . PRO A 1 320 ? 188.921 209.819 140.587 1.00 99.18  ? 313 PRO B CG  1 
ATOM   2122 C  CD  . PRO A 1 320 ? 189.319 208.951 139.433 1.00 101.18 ? 313 PRO B CD  1 
ATOM   2123 N  N   . GLY A 1 321 ? 191.512 207.541 143.329 1.00 96.92  ? 314 GLY B N   1 
ATOM   2124 C  CA  . GLY A 1 321 ? 191.358 206.652 144.458 1.00 97.49  ? 314 GLY B CA  1 
ATOM   2125 C  C   . GLY A 1 321 ? 191.628 205.194 144.171 1.00 98.96  ? 314 GLY B C   1 
ATOM   2126 O  O   . GLY A 1 321 ? 191.472 204.364 145.074 1.00 101.10 ? 314 GLY B O   1 
ATOM   2127 N  N   . MET A 1 322 ? 192.028 204.851 142.947 1.00 97.59  ? 315 MET B N   1 
ATOM   2128 C  CA  . MET A 1 322 ? 192.285 203.459 142.605 1.00 94.45  ? 315 MET B CA  1 
ATOM   2129 C  C   . MET A 1 322 ? 193.495 202.902 143.343 1.00 96.30  ? 315 MET B C   1 
ATOM   2130 O  O   . MET A 1 322 ? 193.583 201.686 143.539 1.00 96.09  ? 315 MET B O   1 
ATOM   2131 C  CB  . MET A 1 322 ? 192.462 203.337 141.089 1.00 94.57  ? 315 MET B CB  1 
ATOM   2132 C  CG  . MET A 1 322 ? 193.143 202.074 140.606 1.00 96.08  ? 315 MET B CG  1 
ATOM   2133 S  SD  . MET A 1 322 ? 192.067 200.636 140.671 1.00 96.77  ? 315 MET B SD  1 
ATOM   2134 C  CE  . MET A 1 322 ? 193.279 199.325 140.580 1.00 84.75  ? 315 MET B CE  1 
ATOM   2135 N  N   . ALA A 1 323 ? 194.403 203.766 143.796 1.00 99.02  ? 316 ALA B N   1 
ATOM   2136 C  CA  . ALA A 1 323 ? 195.640 203.323 144.427 1.00 101.32 ? 316 ALA B CA  1 
ATOM   2137 C  C   . ALA A 1 323 ? 195.415 202.549 145.718 1.00 103.13 ? 316 ALA B C   1 
ATOM   2138 O  O   . ALA A 1 323 ? 196.335 201.862 146.173 1.00 103.99 ? 316 ALA B O   1 
ATOM   2139 C  CB  . ALA A 1 323 ? 196.545 204.524 144.704 1.00 98.46  ? 316 ALA B CB  1 
ATOM   2140 N  N   . GLN A 1 324 ? 194.230 202.635 146.314 1.00 100.24 ? 317 GLN B N   1 
ATOM   2141 C  CA  . GLN A 1 324 ? 193.953 201.978 147.581 1.00 95.40  ? 317 GLN B CA  1 
ATOM   2142 C  C   . GLN A 1 324 ? 193.288 200.619 147.405 1.00 90.72  ? 317 GLN B C   1 
ATOM   2143 O  O   . GLN A 1 324 ? 192.496 200.216 148.263 1.00 89.30  ? 317 GLN B O   1 
ATOM   2144 C  CB  . GLN A 1 324 ? 193.082 202.878 148.458 1.00 100.35 ? 317 GLN B CB  1 
ATOM   2145 C  CG  . GLN A 1 324 ? 193.180 204.360 148.125 1.00 108.39 ? 317 GLN B CG  1 
ATOM   2146 C  CD  . GLN A 1 324 ? 194.528 204.957 148.477 1.00 112.80 ? 317 GLN B CD  1 
ATOM   2147 O  OE1 . GLN A 1 324 ? 195.253 205.437 147.606 1.00 112.19 ? 317 GLN B OE1 1 
ATOM   2148 N  NE2 . GLN A 1 324 ? 194.867 204.937 149.759 1.00 111.66 ? 317 GLN B NE2 1 
ATOM   2149 N  N   . MET A 1 325 ? 193.586 199.905 146.317 1.00 90.98  ? 318 MET B N   1 
ATOM   2150 C  CA  . MET A 1 325 ? 192.970 198.610 146.049 1.00 86.11  ? 318 MET B CA  1 
ATOM   2151 C  C   . MET A 1 325 ? 193.985 197.567 145.607 1.00 81.66  ? 318 MET B C   1 
ATOM   2152 O  O   . MET A 1 325 ? 193.683 196.719 144.767 1.00 80.53  ? 318 MET B O   1 
ATOM   2153 C  CB  . MET A 1 325 ? 191.862 198.735 145.010 1.00 80.59  ? 318 MET B CB  1 
ATOM   2154 C  CG  . MET A 1 325 ? 190.678 199.480 145.527 1.00 82.61  ? 318 MET B CG  1 
ATOM   2155 S  SD  . MET A 1 325 ? 189.180 199.025 144.668 1.00 103.49 ? 318 MET B SD  1 
ATOM   2156 C  CE  . MET A 1 325 ? 188.040 200.026 145.592 1.00 94.54  ? 318 MET B CE  1 
ATOM   2157 N  N   . GLY A 1 326 ? 195.187 197.610 146.159 1.00 78.72  ? 319 GLY B N   1 
ATOM   2158 C  CA  . GLY A 1 326 ? 196.146 196.550 145.953 1.00 75.43  ? 319 GLY B CA  1 
ATOM   2159 C  C   . GLY A 1 326 ? 196.905 196.674 144.648 1.00 77.84  ? 319 GLY B C   1 
ATOM   2160 O  O   . GLY A 1 326 ? 196.633 197.521 143.796 1.00 82.01  ? 319 GLY B O   1 
ATOM   2161 N  N   . THR A 1 327 ? 197.891 195.795 144.501 1.00 76.01  ? 320 THR B N   1 
ATOM   2162 C  CA  . THR A 1 327 ? 198.721 195.785 143.308 1.00 73.21  ? 320 THR B CA  1 
ATOM   2163 C  C   . THR A 1 327 ? 198.004 195.089 142.162 1.00 71.77  ? 320 THR B C   1 
ATOM   2164 O  O   . THR A 1 327 ? 197.364 194.053 142.347 1.00 73.08  ? 320 THR B O   1 
ATOM   2165 C  CB  . THR A 1 327 ? 200.040 195.081 143.596 1.00 74.06  ? 320 THR B CB  1 
ATOM   2166 O  OG1 . THR A 1 327 ? 199.787 193.696 143.859 1.00 70.20  ? 320 THR B OG1 1 
ATOM   2167 C  CG2 . THR A 1 327 ? 200.709 195.703 144.805 1.00 78.02  ? 320 THR B CG2 1 
ATOM   2168 N  N   . VAL A 1 328 ? 198.126 195.657 140.969 1.00 71.35  ? 321 VAL B N   1 
ATOM   2169 C  CA  . VAL A 1 328 ? 197.507 195.110 139.770 1.00 70.82  ? 321 VAL B CA  1 
ATOM   2170 C  C   . VAL A 1 328 ? 198.592 194.399 138.978 1.00 74.76  ? 321 VAL B C   1 
ATOM   2171 O  O   . VAL A 1 328 ? 199.512 195.037 138.458 1.00 81.11  ? 321 VAL B O   1 
ATOM   2172 C  CB  . VAL A 1 328 ? 196.834 196.204 138.934 1.00 69.16  ? 321 VAL B CB  1 
ATOM   2173 C  CG1 . VAL A 1 328 ? 196.443 195.658 137.580 1.00 71.47  ? 321 VAL B CG1 1 
ATOM   2174 C  CG2 . VAL A 1 328 ? 195.623 196.743 139.659 1.00 70.25  ? 321 VAL B CG2 1 
ATOM   2175 N  N   . LEU A 1 329 ? 198.486 193.081 138.880 1.00 68.95  ? 322 LEU B N   1 
ATOM   2176 C  CA  . LEU A 1 329 ? 199.470 192.242 138.203 1.00 65.40  ? 322 LEU B CA  1 
ATOM   2177 C  C   . LEU A 1 329 ? 198.833 191.707 136.926 1.00 69.50  ? 322 LEU B C   1 
ATOM   2178 O  O   . LEU A 1 329 ? 197.987 190.813 136.976 1.00 70.90  ? 322 LEU B O   1 
ATOM   2179 C  CB  . LEU A 1 329 ? 199.921 191.107 139.113 1.00 59.06  ? 322 LEU B CB  1 
ATOM   2180 C  CG  . LEU A 1 329 ? 201.208 191.307 139.898 1.00 61.99  ? 322 LEU B CG  1 
ATOM   2181 C  CD1 . LEU A 1 329 ? 201.527 190.055 140.674 1.00 68.10  ? 322 LEU B CD1 1 
ATOM   2182 C  CD2 . LEU A 1 329 ? 202.334 191.637 138.957 1.00 68.87  ? 322 LEU B CD2 1 
ATOM   2183 N  N   . GLY A 1 330 ? 199.245 192.246 135.781 1.00 71.98  ? 323 GLY B N   1 
ATOM   2184 C  CA  . GLY A 1 330 ? 198.680 191.842 134.516 1.00 75.72  ? 323 GLY B CA  1 
ATOM   2185 C  C   . GLY A 1 330 ? 199.756 191.436 133.530 1.00 79.55  ? 323 GLY B C   1 
ATOM   2186 O  O   . GLY A 1 330 ? 200.935 191.745 133.694 1.00 81.55  ? 323 GLY B O   1 
ATOM   2187 N  N   . PHE A 1 331 ? 199.321 190.732 132.490 1.00 78.01  ? 324 PHE B N   1 
ATOM   2188 C  CA  . PHE A 1 331 ? 200.191 190.292 131.410 1.00 77.08  ? 324 PHE B CA  1 
ATOM   2189 C  C   . PHE A 1 331 ? 199.930 191.146 130.181 1.00 80.36  ? 324 PHE B C   1 
ATOM   2190 O  O   . PHE A 1 331 ? 198.779 191.299 129.763 1.00 83.64  ? 324 PHE B O   1 
ATOM   2191 C  CB  . PHE A 1 331 ? 199.960 188.817 131.086 1.00 74.23  ? 324 PHE B CB  1 
ATOM   2192 C  CG  . PHE A 1 331 ? 200.719 187.878 131.972 1.00 75.18  ? 324 PHE B CG  1 
ATOM   2193 C  CD1 . PHE A 1 331 ? 202.040 187.579 131.713 1.00 78.24  ? 324 PHE B CD1 1 
ATOM   2194 C  CD2 . PHE A 1 331 ? 200.111 187.293 133.064 1.00 74.70  ? 324 PHE B CD2 1 
ATOM   2195 C  CE1 . PHE A 1 331 ? 202.739 186.716 132.526 1.00 75.89  ? 324 PHE B CE1 1 
ATOM   2196 C  CE2 . PHE A 1 331 ? 200.807 186.428 133.878 1.00 72.54  ? 324 PHE B CE2 1 
ATOM   2197 C  CZ  . PHE A 1 331 ? 202.121 186.140 133.607 1.00 71.65  ? 324 PHE B CZ  1 
ATOM   2198 N  N   . LEU A 1 332 ? 200.994 191.696 129.607 1.00 80.29  ? 325 LEU B N   1 
ATOM   2199 C  CA  . LEU A 1 332 ? 200.908 192.569 128.447 1.00 81.23  ? 325 LEU B CA  1 
ATOM   2200 C  C   . LEU A 1 332 ? 201.695 191.966 127.294 1.00 85.57  ? 325 LEU B C   1 
ATOM   2201 O  O   . LEU A 1 332 ? 202.732 191.333 127.497 1.00 88.96  ? 325 LEU B O   1 
ATOM   2202 C  CB  . LEU A 1 332 ? 201.444 193.964 128.767 1.00 77.93  ? 325 LEU B CB  1 
ATOM   2203 C  CG  . LEU A 1 332 ? 201.204 195.041 127.715 1.00 81.34  ? 325 LEU B CG  1 
ATOM   2204 C  CD1 . LEU A 1 332 ? 199.721 195.214 127.470 1.00 83.06  ? 325 LEU B CD1 1 
ATOM   2205 C  CD2 . LEU A 1 332 ? 201.833 196.350 128.145 1.00 82.82  ? 325 LEU B CD2 1 
ATOM   2206 N  N   . GLN A 1 333 ? 201.192 192.165 126.080 1.00 86.25  ? 326 GLN B N   1 
ATOM   2207 C  CA  . GLN A 1 333 ? 201.842 191.608 124.901 1.00 83.60  ? 326 GLN B CA  1 
ATOM   2208 C  C   . GLN A 1 333 ? 203.195 192.265 124.666 1.00 84.86  ? 326 GLN B C   1 
ATOM   2209 O  O   . GLN A 1 333 ? 203.381 193.456 124.925 1.00 88.97  ? 326 GLN B O   1 
ATOM   2210 C  CB  . GLN A 1 333 ? 200.954 191.791 123.674 1.00 85.81  ? 326 GLN B CB  1 
ATOM   2211 C  CG  . GLN A 1 333 ? 201.352 190.936 122.494 1.00 86.61  ? 326 GLN B CG  1 
ATOM   2212 C  CD  . GLN A 1 333 ? 200.409 191.099 121.325 1.00 92.38  ? 326 GLN B CD  1 
ATOM   2213 O  OE1 . GLN A 1 333 ? 200.828 191.405 120.211 1.00 96.25  ? 326 GLN B OE1 1 
ATOM   2214 N  NE2 . GLN A 1 333 ? 199.122 190.895 121.574 1.00 89.67  ? 326 GLN B NE2 1 
ATOM   2215 N  N   . ARG A 1 334 ? 204.145 191.478 124.177 1.00 85.66  ? 327 ARG B N   1 
ATOM   2216 C  CA  . ARG A 1 334 ? 205.500 191.944 123.898 1.00 91.20  ? 327 ARG B CA  1 
ATOM   2217 C  C   . ARG A 1 334 ? 205.728 191.837 122.393 1.00 93.26  ? 327 ARG B C   1 
ATOM   2218 O  O   . ARG A 1 334 ? 206.248 190.837 121.897 1.00 92.96  ? 327 ARG B O   1 
ATOM   2219 C  CB  . ARG A 1 334 ? 206.526 191.134 124.680 1.00 92.01  ? 327 ARG B CB  1 
ATOM   2220 C  CG  . ARG A 1 334 ? 207.920 191.725 124.674 1.00 95.67  ? 327 ARG B CG  1 
ATOM   2221 C  CD  . ARG A 1 334 ? 208.689 191.316 125.917 1.00 100.32 ? 327 ARG B CD  1 
ATOM   2222 N  NE  . ARG A 1 334 ? 210.080 190.996 125.623 1.00 104.21 ? 327 ARG B NE  1 
ATOM   2223 C  CZ  . ARG A 1 334 ? 211.017 191.896 125.359 1.00 101.08 ? 327 ARG B CZ  1 
ATOM   2224 N  NH1 . ARG A 1 334 ? 210.750 193.192 125.353 1.00 99.24  ? 327 ARG B NH1 1 
ATOM   2225 N  NH2 . ARG A 1 334 ? 212.254 191.486 125.096 1.00 96.97  ? 327 ARG B NH2 1 
ATOM   2226 N  N   . GLY A 1 335 ? 205.339 192.884 121.666 1.00 93.10  ? 328 GLY B N   1 
ATOM   2227 C  CA  . GLY A 1 335 ? 205.463 192.890 120.228 1.00 95.88  ? 328 GLY B CA  1 
ATOM   2228 C  C   . GLY A 1 335 ? 206.090 194.179 119.736 1.00 97.76  ? 328 GLY B C   1 
ATOM   2229 O  O   . GLY A 1 335 ? 206.074 195.207 120.412 1.00 97.27  ? 328 GLY B O   1 
ATOM   2230 N  N   . ALA A 1 336 ? 206.643 194.103 118.529 1.00 94.89  ? 329 ALA B N   1 
ATOM   2231 C  CA  . ALA A 1 336 ? 207.311 195.241 117.915 1.00 89.71  ? 329 ALA B CA  1 
ATOM   2232 C  C   . ALA A 1 336 ? 206.267 196.200 117.352 1.00 88.67  ? 329 ALA B C   1 
ATOM   2233 O  O   . ALA A 1 336 ? 205.064 196.056 117.584 1.00 89.31  ? 329 ALA B O   1 
ATOM   2234 C  CB  . ALA A 1 336 ? 208.289 194.765 116.846 1.00 84.32  ? 329 ALA B CB  1 
ATOM   2235 N  N   . GLN A 1 337 ? 206.720 197.204 116.606 1.00 89.40  ? 330 GLN B N   1 
ATOM   2236 C  CA  . GLN A 1 337 ? 205.811 198.172 116.014 1.00 92.45  ? 330 GLN B CA  1 
ATOM   2237 C  C   . GLN A 1 337 ? 206.414 198.710 114.726 1.00 93.65  ? 330 GLN B C   1 
ATOM   2238 O  O   . GLN A 1 337 ? 207.636 198.760 114.567 1.00 96.78  ? 330 GLN B O   1 
ATOM   2239 C  CB  . GLN A 1 337 ? 205.509 199.320 116.983 1.00 95.21  ? 330 GLN B CB  1 
ATOM   2240 C  CG  . GLN A 1 337 ? 206.691 199.733 117.838 1.00 99.75  ? 330 GLN B CG  1 
ATOM   2241 C  CD  . GLN A 1 337 ? 206.388 200.943 118.694 1.00 104.18 ? 330 GLN B CD  1 
ATOM   2242 O  OE1 . GLN A 1 337 ? 205.301 201.059 119.259 1.00 107.62 ? 330 GLN B OE1 1 
ATOM   2243 N  NE2 . GLN A 1 337 ? 207.349 201.855 118.794 1.00 100.14 ? 330 GLN B NE2 1 
ATOM   2244 N  N   . LEU A 1 338 ? 205.539 199.117 113.812 1.00 91.34  ? 331 LEU B N   1 
ATOM   2245 C  CA  . LEU A 1 338 ? 205.953 199.681 112.531 1.00 88.82  ? 331 LEU B CA  1 
ATOM   2246 C  C   . LEU A 1 338 ? 206.547 201.057 112.782 1.00 93.81  ? 331 LEU B C   1 
ATOM   2247 O  O   . LEU A 1 338 ? 205.821 202.031 112.989 1.00 96.00  ? 331 LEU B O   1 
ATOM   2248 C  CB  . LEU A 1 338 ? 204.766 199.766 111.582 1.00 86.18  ? 331 LEU B CB  1 
ATOM   2249 C  CG  . LEU A 1 338 ? 204.313 198.479 110.905 1.00 81.52  ? 331 LEU B CG  1 
ATOM   2250 C  CD1 . LEU A 1 338 ? 202.832 198.557 110.595 1.00 75.82  ? 331 LEU B CD1 1 
ATOM   2251 C  CD2 . LEU A 1 338 ? 205.110 198.244 109.641 1.00 82.77  ? 331 LEU B CD2 1 
ATOM   2252 N  N   . HIS A 1 339 ? 207.876 201.146 112.766 1.00 96.67  ? 332 HIS B N   1 
ATOM   2253 C  CA  . HIS A 1 339 ? 208.528 202.413 113.075 1.00 99.49  ? 332 HIS B CA  1 
ATOM   2254 C  C   . HIS A 1 339 ? 208.198 203.480 112.040 1.00 97.95  ? 332 HIS B C   1 
ATOM   2255 O  O   . HIS A 1 339 ? 207.969 204.643 112.391 1.00 97.38  ? 332 HIS B O   1 
ATOM   2256 C  CB  . HIS A 1 339 ? 210.037 202.212 113.185 1.00 99.64  ? 332 HIS B CB  1 
ATOM   2257 C  CG  . HIS A 1 339 ? 210.452 201.440 114.396 1.00 108.75 ? 332 HIS B CG  1 
ATOM   2258 N  ND1 . HIS A 1 339 ? 209.860 201.617 115.628 1.00 112.05 ? 332 HIS B ND1 1 
ATOM   2259 C  CD2 . HIS A 1 339 ? 211.401 200.490 114.568 1.00 112.41 ? 332 HIS B CD2 1 
ATOM   2260 C  CE1 . HIS A 1 339 ? 210.425 200.808 116.506 1.00 112.18 ? 332 HIS B CE1 1 
ATOM   2261 N  NE2 . HIS A 1 339 ? 211.364 200.114 115.889 1.00 114.10 ? 332 HIS B NE2 1 
ATOM   2262 N  N   . GLU A 1 340 ? 208.161 203.109 110.766 1.00 98.39  ? 333 GLU B N   1 
ATOM   2263 C  CA  . GLU A 1 340 ? 207.961 204.073 109.695 1.00 96.50  ? 333 GLU B CA  1 
ATOM   2264 C  C   . GLU A 1 340 ? 206.498 204.273 109.330 1.00 94.97  ? 333 GLU B C   1 
ATOM   2265 O  O   . GLU A 1 340 ? 206.210 205.027 108.396 1.00 98.60  ? 333 GLU B O   1 
ATOM   2266 C  CB  . GLU A 1 340 ? 208.742 203.644 108.450 1.00 98.74  ? 333 GLU B CB  1 
ATOM   2267 C  CG  . GLU A 1 340 ? 208.112 202.495 107.693 1.00 96.60  ? 333 GLU B CG  1 
ATOM   2268 C  CD  . GLU A 1 340 ? 208.771 201.170 108.001 1.00 103.93 ? 333 GLU B CD  1 
ATOM   2269 O  OE1 . GLU A 1 340 ? 209.453 201.070 109.042 1.00 108.24 ? 333 GLU B OE1 1 
ATOM   2270 O  OE2 . GLU A 1 340 ? 208.613 200.226 107.200 1.00 100.86 ? 333 GLU B OE2 1 
ATOM   2271 N  N   . PHE A 1 341 ? 205.570 203.621 110.028 1.00 92.70  ? 334 PHE B N   1 
ATOM   2272 C  CA  . PHE A 1 341 ? 204.159 203.793 109.694 1.00 91.53  ? 334 PHE B CA  1 
ATOM   2273 C  C   . PHE A 1 341 ? 203.661 205.224 109.852 1.00 92.91  ? 334 PHE B C   1 
ATOM   2274 O  O   . PHE A 1 341 ? 202.922 205.682 108.965 1.00 93.68  ? 334 PHE B O   1 
ATOM   2275 C  CB  . PHE A 1 341 ? 203.291 202.846 110.525 1.00 87.16  ? 334 PHE B CB  1 
ATOM   2276 C  CG  . PHE A 1 341 ? 201.835 202.932 110.196 1.00 82.41  ? 334 PHE B CG  1 
ATOM   2277 C  CD1 . PHE A 1 341 ? 201.390 202.665 108.919 1.00 81.62  ? 334 PHE B CD1 1 
ATOM   2278 C  CD2 . PHE A 1 341 ? 200.913 203.293 111.153 1.00 83.77  ? 334 PHE B CD2 1 
ATOM   2279 C  CE1 . PHE A 1 341 ? 200.055 202.743 108.608 1.00 81.34  ? 334 PHE B CE1 1 
ATOM   2280 C  CE2 . PHE A 1 341 ? 199.574 203.374 110.843 1.00 81.59  ? 334 PHE B CE2 1 
ATOM   2281 C  CZ  . PHE A 1 341 ? 199.147 203.097 109.571 1.00 79.46  ? 334 PHE B CZ  1 
ATOM   2282 N  N   . PRO A 1 342 ? 203.961 205.958 110.931 1.00 94.40  ? 335 PRO B N   1 
ATOM   2283 C  CA  . PRO A 1 342 ? 203.507 207.358 110.983 1.00 95.72  ? 335 PRO B CA  1 
ATOM   2284 C  C   . PRO A 1 342 ? 204.023 208.194 109.828 1.00 97.99  ? 335 PRO B C   1 
ATOM   2285 O  O   . PRO A 1 342 ? 203.283 209.024 109.286 1.00 98.28  ? 335 PRO B O   1 
ATOM   2286 C  CB  . PRO A 1 342 ? 204.048 207.851 112.333 1.00 94.94  ? 335 PRO B CB  1 
ATOM   2287 C  CG  . PRO A 1 342 ? 205.110 206.884 112.705 1.00 95.08  ? 335 PRO B CG  1 
ATOM   2288 C  CD  . PRO A 1 342 ? 204.649 205.575 112.174 1.00 94.41  ? 335 PRO B CD  1 
ATOM   2289 N  N   . GLN A 1 343 ? 205.278 207.984 109.426 1.00 97.13  ? 336 GLN B N   1 
ATOM   2290 C  CA  . GLN A 1 343 ? 205.808 208.702 108.274 1.00 96.47  ? 336 GLN B CA  1 
ATOM   2291 C  C   . GLN A 1 343 ? 205.029 208.355 107.015 1.00 96.99  ? 336 GLN B C   1 
ATOM   2292 O  O   . GLN A 1 343 ? 204.700 209.238 106.213 1.00 98.25  ? 336 GLN B O   1 
ATOM   2293 C  CB  . GLN A 1 343 ? 207.292 208.384 108.094 1.00 96.24  ? 336 GLN B CB  1 
ATOM   2294 C  CG  . GLN A 1 343 ? 207.927 209.043 106.881 1.00 98.20  ? 336 GLN B CG  1 
ATOM   2295 C  CD  . GLN A 1 343 ? 207.768 210.550 106.882 1.00 100.79 ? 336 GLN B CD  1 
ATOM   2296 O  OE1 . GLN A 1 343 ? 207.161 211.121 105.977 1.00 99.30  ? 336 GLN B OE1 1 
ATOM   2297 N  NE2 . GLN A 1 343 ? 208.318 211.203 107.899 1.00 99.18  ? 336 GLN B NE2 1 
ATOM   2298 N  N   . TYR A 1 344 ? 204.716 207.071 106.832 1.00 96.45  ? 337 TYR B N   1 
ATOM   2299 C  CA  . TYR A 1 344 ? 203.934 206.665 105.672 1.00 96.14  ? 337 TYR B CA  1 
ATOM   2300 C  C   . TYR A 1 344 ? 202.560 207.313 105.684 1.00 97.50  ? 337 TYR B C   1 
ATOM   2301 O  O   . TYR A 1 344 ? 202.093 207.806 104.653 1.00 105.17 ? 337 TYR B O   1 
ATOM   2302 C  CB  . TYR A 1 344 ? 203.803 205.145 105.627 1.00 90.78  ? 337 TYR B CB  1 
ATOM   2303 C  CG  . TYR A 1 344 ? 202.913 204.650 104.516 1.00 90.86  ? 337 TYR B CG  1 
ATOM   2304 C  CD1 . TYR A 1 344 ? 203.430 204.391 103.258 1.00 94.27  ? 337 TYR B CD1 1 
ATOM   2305 C  CD2 . TYR A 1 344 ? 201.558 204.441 104.722 1.00 90.19  ? 337 TYR B CD2 1 
ATOM   2306 C  CE1 . TYR A 1 344 ? 202.625 203.938 102.236 1.00 95.15  ? 337 TYR B CE1 1 
ATOM   2307 C  CE2 . TYR A 1 344 ? 200.746 203.992 103.706 1.00 92.75  ? 337 TYR B CE2 1 
ATOM   2308 C  CZ  . TYR A 1 344 ? 201.285 203.739 102.466 1.00 94.90  ? 337 TYR B CZ  1 
ATOM   2309 O  OH  . TYR A 1 344 ? 200.482 203.287 101.447 1.00 91.42  ? 337 TYR B OH  1 
ATOM   2310 N  N   . VAL A 1 345 ? 201.897 207.326 106.839 1.00 91.12  ? 338 VAL B N   1 
ATOM   2311 C  CA  . VAL A 1 345 ? 200.556 207.897 106.912 1.00 94.10  ? 338 VAL B CA  1 
ATOM   2312 C  C   . VAL A 1 345 ? 200.597 209.382 106.590 1.00 98.94  ? 338 VAL B C   1 
ATOM   2313 O  O   . VAL A 1 345 ? 199.783 209.886 105.808 1.00 99.47  ? 338 VAL B O   1 
ATOM   2314 C  CB  . VAL A 1 345 ? 199.927 207.639 108.292 1.00 96.55  ? 338 VAL B CB  1 
ATOM   2315 C  CG1 . VAL A 1 345 ? 198.889 208.700 108.609 1.00 96.95  ? 338 VAL B CG1 1 
ATOM   2316 C  CG2 . VAL A 1 345 ? 199.289 206.277 108.322 1.00 93.27  ? 338 VAL B CG2 1 
ATOM   2317 N  N   . LYS A 1 346 ? 201.548 210.108 107.182 1.00 99.54  ? 339 LYS B N   1 
ATOM   2318 C  CA  . LYS A 1 346 ? 201.586 211.548 106.956 1.00 99.66  ? 339 LYS B CA  1 
ATOM   2319 C  C   . LYS A 1 346 ? 201.923 211.870 105.506 1.00 100.41 ? 339 LYS B C   1 
ATOM   2320 O  O   . LYS A 1 346 ? 201.287 212.740 104.901 1.00 104.54 ? 339 LYS B O   1 
ATOM   2321 C  CB  . LYS A 1 346 ? 202.563 212.225 107.921 1.00 104.40 ? 339 LYS B CB  1 
ATOM   2322 C  CG  . LYS A 1 346 ? 204.018 211.815 107.794 1.00 105.71 ? 339 LYS B CG  1 
ATOM   2323 C  CD  . LYS A 1 346 ? 204.927 212.701 108.637 1.00 108.38 ? 339 LYS B CD  1 
ATOM   2324 C  CE  . LYS A 1 346 ? 204.239 213.163 109.913 1.00 109.26 ? 339 LYS B CE  1 
ATOM   2325 N  NZ  . LYS A 1 346 ? 204.949 214.304 110.552 1.00 106.76 ? 339 LYS B NZ  1 
ATOM   2326 N  N   . THR A 1 347 ? 202.888 211.159 104.912 1.00 98.44  ? 340 THR B N   1 
ATOM   2327 C  CA  . THR A 1 347 ? 203.238 211.460 103.528 1.00 99.71  ? 340 THR B CA  1 
ATOM   2328 C  C   . THR A 1 347 ? 202.118 211.059 102.575 1.00 104.11 ? 340 THR B C   1 
ATOM   2329 O  O   . THR A 1 347 ? 201.849 211.767 101.599 1.00 109.60 ? 340 THR B O   1 
ATOM   2330 C  CB  . THR A 1 347 ? 204.559 210.787 103.145 1.00 100.24 ? 340 THR B CB  1 
ATOM   2331 O  OG1 . THR A 1 347 ? 205.029 211.341 101.911 1.00 106.15 ? 340 THR B OG1 1 
ATOM   2332 C  CG2 . THR A 1 347 ? 204.401 209.287 102.983 1.00 96.18  ? 340 THR B CG2 1 
ATOM   2333 N  N   . HIS A 1 348 ? 201.421 209.957 102.862 1.00 103.04 ? 341 HIS B N   1 
ATOM   2334 C  CA  . HIS A 1 348 ? 200.326 209.532 102.001 1.00 104.58 ? 341 HIS B CA  1 
ATOM   2335 C  C   . HIS A 1 348 ? 199.148 210.489 102.094 1.00 107.51 ? 341 HIS B C   1 
ATOM   2336 O  O   . HIS A 1 348 ? 198.518 210.805 101.080 1.00 110.66 ? 341 HIS B O   1 
ATOM   2337 C  CB  . HIS A 1 348 ? 199.898 208.115 102.370 1.00 101.33 ? 341 HIS B CB  1 
ATOM   2338 C  CG  . HIS A 1 348 ? 199.253 207.370 101.248 1.00 101.85 ? 341 HIS B CG  1 
ATOM   2339 N  ND1 . HIS A 1 348 ? 197.889 207.349 101.057 1.00 105.69 ? 341 HIS B ND1 1 
ATOM   2340 C  CD2 . HIS A 1 348 ? 199.785 206.627 100.250 1.00 100.65 ? 341 HIS B CD2 1 
ATOM   2341 C  CE1 . HIS A 1 348 ? 197.608 206.618 99.993  1.00 105.17 ? 341 HIS B CE1 1 
ATOM   2342 N  NE2 . HIS A 1 348 ? 198.741 206.171 99.483  1.00 103.98 ? 341 HIS B NE2 1 
ATOM   2343 N  N   . LEU A 1 349 ? 198.838 210.966 103.299 1.00 102.68 ? 342 LEU B N   1 
ATOM   2344 C  CA  . LEU A 1 349 ? 197.742 211.913 103.451 1.00 101.12 ? 342 LEU B CA  1 
ATOM   2345 C  C   . LEU A 1 349 ? 198.089 213.259 102.830 1.00 106.11 ? 342 LEU B C   1 
ATOM   2346 O  O   . LEU A 1 349 ? 197.212 213.939 102.285 1.00 110.66 ? 342 LEU B O   1 
ATOM   2347 C  CB  . LEU A 1 349 ? 197.392 212.071 104.927 1.00 101.70 ? 342 LEU B CB  1 
ATOM   2348 C  CG  . LEU A 1 349 ? 196.089 211.400 105.352 1.00 105.27 ? 342 LEU B CG  1 
ATOM   2349 C  CD1 . LEU A 1 349 ? 195.528 212.069 106.589 1.00 112.27 ? 342 LEU B CD1 1 
ATOM   2350 C  CD2 . LEU A 1 349 ? 195.076 211.420 104.221 1.00 101.16 ? 342 LEU B CD2 1 
ATOM   2351 N  N   . ALA A 1 350 ? 199.358 213.666 102.906 1.00 105.97 ? 343 ALA B N   1 
ATOM   2352 C  CA  . ALA A 1 350 ? 199.768 214.896 102.240 1.00 107.63 ? 343 ALA B CA  1 
ATOM   2353 C  C   . ALA A 1 350 ? 199.693 214.757 100.726 1.00 109.88 ? 343 ALA B C   1 
ATOM   2354 O  O   . ALA A 1 350 ? 199.286 215.694 100.031 1.00 111.84 ? 343 ALA B O   1 
ATOM   2355 C  CB  . ALA A 1 350 ? 201.181 215.284 102.674 1.00 106.94 ? 343 ALA B CB  1 
ATOM   2356 N  N   . LEU A 1 351 ? 200.081 213.596 100.196 1.00 110.35 ? 344 LEU B N   1 
ATOM   2357 C  CA  . LEU A 1 351 ? 200.079 213.399 98.753  1.00 114.23 ? 344 LEU B CA  1 
ATOM   2358 C  C   . LEU A 1 351 ? 198.674 213.211 98.193  1.00 118.06 ? 344 LEU B C   1 
ATOM   2359 O  O   . LEU A 1 351 ? 198.412 213.603 97.052  1.00 120.54 ? 344 LEU B O   1 
ATOM   2360 C  CB  . LEU A 1 351 ? 200.981 212.211 98.400  1.00 114.05 ? 344 LEU B CB  1 
ATOM   2361 C  CG  . LEU A 1 351 ? 200.940 211.513 97.039  1.00 120.86 ? 344 LEU B CG  1 
ATOM   2362 C  CD1 . LEU A 1 351 ? 202.266 210.817 96.796  1.00 120.82 ? 344 LEU B CD1 1 
ATOM   2363 C  CD2 . LEU A 1 351 ? 199.827 210.482 96.984  1.00 120.02 ? 344 LEU B CD2 1 
ATOM   2364 N  N   . ALA A 1 352 ? 197.763 212.618 98.966  1.00 116.87 ? 345 ALA B N   1 
ATOM   2365 C  CA  . ALA A 1 352 ? 196.413 212.381 98.471  1.00 115.12 ? 345 ALA B CA  1 
ATOM   2366 C  C   . ALA A 1 352 ? 195.640 213.672 98.244  1.00 115.93 ? 345 ALA B C   1 
ATOM   2367 O  O   . ALA A 1 352 ? 194.640 213.659 97.522  1.00 118.83 ? 345 ALA B O   1 
ATOM   2368 C  CB  . ALA A 1 352 ? 195.647 211.483 99.440  1.00 112.18 ? 345 ALA B CB  1 
ATOM   2369 N  N   . THR A 1 353 ? 196.069 214.779 98.846  1.00 114.24 ? 346 THR B N   1 
ATOM   2370 C  CA  . THR A 1 353 ? 195.391 216.049 98.633  1.00 114.89 ? 346 THR B CA  1 
ATOM   2371 C  C   . THR A 1 353 ? 195.764 216.691 97.302  1.00 118.36 ? 346 THR B C   1 
ATOM   2372 O  O   . THR A 1 353 ? 195.066 217.604 96.850  1.00 119.20 ? 346 THR B O   1 
ATOM   2373 C  CB  . THR A 1 353 ? 195.705 217.006 99.786  1.00 114.12 ? 346 THR B CB  1 
ATOM   2374 O  OG1 . THR A 1 353 ? 195.684 216.281 101.020 1.00 110.40 ? 346 THR B OG1 1 
ATOM   2375 C  CG2 . THR A 1 353 ? 194.666 218.110 99.863  1.00 114.80 ? 346 THR B CG2 1 
ATOM   2376 N  N   . ASP A 1 354 ? 196.828 216.230 96.662  1.00 118.97 ? 347 ASP B N   1 
ATOM   2377 C  CA  . ASP A 1 354 ? 197.229 216.781 95.372  1.00 124.86 ? 347 ASP B CA  1 
ATOM   2378 C  C   . ASP A 1 354 ? 196.235 216.367 94.295  1.00 129.49 ? 347 ASP B C   1 
ATOM   2379 O  O   . ASP A 1 354 ? 196.040 215.164 94.075  1.00 128.47 ? 347 ASP B O   1 
ATOM   2380 C  CB  . ASP A 1 354 ? 198.633 216.305 95.012  1.00 125.53 ? 347 ASP B CB  1 
ATOM   2381 C  CG  . ASP A 1 354 ? 199.287 217.166 93.950  1.00 127.19 ? 347 ASP B CG  1 
ATOM   2382 O  OD1 . ASP A 1 354 ? 198.738 217.259 92.833  1.00 127.72 ? 347 ASP B OD1 1 
ATOM   2383 O  OD2 . ASP A 1 354 ? 200.354 217.751 94.233  1.00 125.06 ? 347 ASP B OD2 1 
ATOM   2384 N  N   . PRO A 1 355 ? 195.588 217.312 93.606  1.00 132.73 ? 348 PRO B N   1 
ATOM   2385 C  CA  . PRO A 1 355 ? 194.628 216.928 92.557  1.00 131.28 ? 348 PRO B CA  1 
ATOM   2386 C  C   . PRO A 1 355 ? 195.250 216.143 91.417  1.00 129.69 ? 348 PRO B C   1 
ATOM   2387 O  O   . PRO A 1 355 ? 194.564 215.316 90.804  1.00 128.46 ? 348 PRO B O   1 
ATOM   2388 C  CB  . PRO A 1 355 ? 194.074 218.277 92.076  1.00 126.36 ? 348 PRO B CB  1 
ATOM   2389 C  CG  . PRO A 1 355 ? 194.374 219.238 93.180  1.00 127.19 ? 348 PRO B CG  1 
ATOM   2390 C  CD  . PRO A 1 355 ? 195.656 218.770 93.790  1.00 127.90 ? 348 PRO B CD  1 
ATOM   2391 N  N   . ALA A 1 356 ? 196.525 216.387 91.103  1.00 128.19 ? 349 ALA B N   1 
ATOM   2392 C  CA  . ALA A 1 356 ? 197.167 215.663 90.010  1.00 126.00 ? 349 ALA B CA  1 
ATOM   2393 C  C   . ALA A 1 356 ? 197.227 214.170 90.298  1.00 130.22 ? 349 ALA B C   1 
ATOM   2394 O  O   . ALA A 1 356 ? 196.964 213.347 89.413  1.00 128.40 ? 349 ALA B O   1 
ATOM   2395 C  CB  . ALA A 1 356 ? 198.568 216.220 89.764  1.00 120.90 ? 349 ALA B CB  1 
ATOM   2396 N  N   . PHE A 1 357 ? 197.567 213.801 91.534  1.00 130.71 ? 350 PHE B N   1 
ATOM   2397 C  CA  . PHE A 1 357 ? 197.626 212.389 91.894  1.00 129.38 ? 350 PHE B CA  1 
ATOM   2398 C  C   . PHE A 1 357 ? 196.252 211.737 91.801  1.00 131.17 ? 350 PHE B C   1 
ATOM   2399 O  O   . PHE A 1 357 ? 196.120 210.618 91.288  1.00 129.65 ? 350 PHE B O   1 
ATOM   2400 C  CB  . PHE A 1 357 ? 198.201 212.238 93.300  1.00 123.96 ? 350 PHE B CB  1 
ATOM   2401 C  CG  . PHE A 1 357 ? 198.259 210.821 93.782  1.00 121.86 ? 350 PHE B CG  1 
ATOM   2402 C  CD1 . PHE A 1 357 ? 199.311 210.000 93.427  1.00 121.20 ? 350 PHE B CD1 1 
ATOM   2403 C  CD2 . PHE A 1 357 ? 197.261 210.311 94.590  1.00 120.33 ? 350 PHE B CD2 1 
ATOM   2404 C  CE1 . PHE A 1 357 ? 199.365 208.697 93.870  1.00 119.47 ? 350 PHE B CE1 1 
ATOM   2405 C  CE2 . PHE A 1 357 ? 197.311 209.011 95.032  1.00 118.49 ? 350 PHE B CE2 1 
ATOM   2406 C  CZ  . PHE A 1 357 ? 198.363 208.202 94.674  1.00 115.95 ? 350 PHE B CZ  1 
ATOM   2407 N  N   . CYS A 1 358 ? 195.216 212.421 92.294  1.00 130.46 ? 351 CYS B N   1 
ATOM   2408 C  CA  . CYS A 1 358 ? 193.867 211.867 92.237  1.00 127.73 ? 351 CYS B CA  1 
ATOM   2409 C  C   . CYS A 1 358 ? 193.395 211.716 90.797  1.00 130.86 ? 351 CYS B C   1 
ATOM   2410 O  O   . CYS A 1 358 ? 192.719 210.738 90.456  1.00 128.06 ? 351 CYS B O   1 
ATOM   2411 C  CB  . CYS A 1 358 ? 192.905 212.749 93.027  1.00 123.54 ? 351 CYS B CB  1 
ATOM   2412 S  SG  . CYS A 1 358 ? 193.468 213.142 94.693  1.00 132.77 ? 351 CYS B SG  1 
ATOM   2413 N  N   . SER A 1 359 ? 193.730 212.683 89.940  1.00 134.40 ? 352 SER B N   1 
ATOM   2414 C  CA  . SER A 1 359 ? 193.413 212.555 88.523  1.00 133.54 ? 352 SER B CA  1 
ATOM   2415 C  C   . SER A 1 359 ? 194.147 211.373 87.905  1.00 134.84 ? 352 SER B C   1 
ATOM   2416 O  O   . SER A 1 359 ? 193.579 210.635 87.091  1.00 133.68 ? 352 SER B O   1 
ATOM   2417 C  CB  . SER A 1 359 ? 193.764 213.849 87.788  1.00 126.29 ? 352 SER B CB  1 
ATOM   2418 O  OG  . SER A 1 359 ? 192.854 214.884 88.117  1.00 122.30 ? 352 SER B OG  1 
ATOM   2419 N  N   . ALA A 1 360 ? 195.412 211.178 88.282  1.00 135.15 ? 353 ALA B N   1 
ATOM   2420 C  CA  . ALA A 1 360 ? 196.179 210.053 87.760  1.00 136.22 ? 353 ALA B CA  1 
ATOM   2421 C  C   . ALA A 1 360 ? 195.564 208.723 88.174  1.00 132.98 ? 353 ALA B C   1 
ATOM   2422 O  O   . ALA A 1 360 ? 195.494 207.785 87.371  1.00 130.51 ? 353 ALA B O   1 
ATOM   2423 C  CB  . ALA A 1 360 ? 197.629 210.145 88.232  1.00 135.14 ? 353 ALA B CB  1 
ATOM   2424 N  N   . LEU A 1 361 ? 195.114 208.622 89.420  1.00 129.86 ? 354 LEU B N   1 
ATOM   2425 C  CA  . LEU A 1 361 ? 194.503 207.393 89.910  1.00 128.72 ? 354 LEU B CA  1 
ATOM   2426 C  C   . LEU A 1 361 ? 193.143 207.155 89.258  1.00 126.49 ? 354 LEU B C   1 
ATOM   2427 O  O   . LEU A 1 361 ? 192.997 206.276 88.409  1.00 122.55 ? 354 LEU B O   1 
ATOM   2428 C  CB  . LEU A 1 361 ? 194.355 207.438 91.432  1.00 124.43 ? 354 LEU B CB  1 
ATOM   2429 C  CG  . LEU A 1 361 ? 195.386 206.637 92.228  1.00 118.42 ? 354 LEU B CG  1 
ATOM   2430 C  CD1 . LEU A 1 361 ? 195.088 205.149 92.144  1.00 110.54 ? 354 LEU B CD1 1 
ATOM   2431 C  CD2 . LEU A 1 361 ? 196.789 206.934 91.730  1.00 120.28 ? 354 LEU B CD2 1 
ATOM   2432 N  N   . GLN A 1 375 ? 180.336 204.555 97.381  1.00 106.29 ? 368 GLN B N   1 
ATOM   2433 C  CA  . GLN A 1 375 ? 181.737 204.194 97.556  1.00 111.58 ? 368 GLN B CA  1 
ATOM   2434 C  C   . GLN A 1 375 ? 181.921 203.359 98.820  1.00 114.83 ? 368 GLN B C   1 
ATOM   2435 O  O   . GLN A 1 375 ? 181.007 203.244 99.635  1.00 115.26 ? 368 GLN B O   1 
ATOM   2436 C  CB  . GLN A 1 375 ? 182.613 205.448 97.608  1.00 109.60 ? 368 GLN B CB  1 
ATOM   2437 C  CG  . GLN A 1 375 ? 184.057 205.227 97.178  1.00 106.80 ? 368 GLN B CG  1 
ATOM   2438 C  CD  . GLN A 1 375 ? 184.191 204.930 95.699  1.00 109.46 ? 368 GLN B CD  1 
ATOM   2439 O  OE1 . GLN A 1 375 ? 184.803 203.936 95.306  1.00 106.11 ? 368 GLN B OE1 1 
ATOM   2440 N  NE2 . GLN A 1 375 ? 183.622 205.794 94.869  1.00 105.98 ? 368 GLN B NE2 1 
ATOM   2441 N  N   . ARG A 1 376 ? 183.110 202.770 98.966  1.00 113.14 ? 369 ARG B N   1 
ATOM   2442 C  CA  . ARG A 1 376 ? 183.381 201.913 100.115 1.00 107.53 ? 369 ARG B CA  1 
ATOM   2443 C  C   . ARG A 1 376 ? 183.322 202.695 101.420 1.00 108.97 ? 369 ARG B C   1 
ATOM   2444 O  O   . ARG A 1 376 ? 182.733 202.232 102.404 1.00 102.99 ? 369 ARG B O   1 
ATOM   2445 C  CB  . ARG A 1 376 ? 184.746 201.248 99.953  1.00 94.27  ? 369 ARG B CB  1 
ATOM   2446 C  CG  . ARG A 1 376 ? 184.928 200.547 98.629  1.00 83.97  ? 369 ARG B CG  1 
ATOM   2447 C  CD  . ARG A 1 376 ? 184.769 199.058 98.792  1.00 76.44  ? 369 ARG B CD  1 
ATOM   2448 N  NE  . ARG A 1 376 ? 184.743 198.371 97.509  1.00 80.96  ? 369 ARG B NE  1 
ATOM   2449 C  CZ  . ARG A 1 376 ? 185.823 198.046 96.815  1.00 84.25  ? 369 ARG B CZ  1 
ATOM   2450 N  NH1 . ARG A 1 376 ? 187.037 198.345 97.247  1.00 78.98  ? 369 ARG B NH1 1 
ATOM   2451 N  NH2 . ARG A 1 376 ? 185.683 197.403 95.659  1.00 85.00  ? 369 ARG B NH2 1 
ATOM   2452 N  N   . CYS A 1 377 ? 183.922 203.882 101.448 1.00 112.28 ? 370 CYS B N   1 
ATOM   2453 C  CA  . CYS A 1 377 ? 183.959 204.720 102.646 1.00 116.66 ? 370 CYS B CA  1 
ATOM   2454 C  C   . CYS A 1 377 ? 183.819 206.176 102.233 1.00 120.82 ? 370 CYS B C   1 
ATOM   2455 O  O   . CYS A 1 377 ? 184.804 206.921 102.173 1.00 120.83 ? 370 CYS B O   1 
ATOM   2456 C  CB  . CYS A 1 377 ? 185.250 204.497 103.436 1.00 113.63 ? 370 CYS B CB  1 
ATOM   2457 S  SG  . CYS A 1 377 ? 185.325 205.400 104.997 1.00 128.17 ? 370 CYS B SG  1 
ATOM   2458 N  N   . PRO A 1 378 ? 182.597 206.619 101.930 1.00 122.54 ? 371 PRO B N   1 
ATOM   2459 C  CA  . PRO A 1 378 ? 182.409 208.032 101.566 1.00 123.01 ? 371 PRO B CA  1 
ATOM   2460 C  C   . PRO A 1 378 ? 182.838 208.992 102.657 1.00 125.73 ? 371 PRO B C   1 
ATOM   2461 O  O   . PRO A 1 378 ? 183.310 210.093 102.349 1.00 124.82 ? 371 PRO B O   1 
ATOM   2462 C  CB  . PRO A 1 378 ? 180.903 208.125 101.287 1.00 118.53 ? 371 PRO B CB  1 
ATOM   2463 C  CG  . PRO A 1 378 ? 180.306 206.969 102.014 1.00 117.84 ? 371 PRO B CG  1 
ATOM   2464 C  CD  . PRO A 1 378 ? 181.327 205.878 101.943 1.00 119.68 ? 371 PRO B CD  1 
ATOM   2465 N  N   . GLN A 1 379 ? 182.692 208.609 103.927 1.00 125.76 ? 372 GLN B N   1 
ATOM   2466 C  CA  . GLN A 1 379 ? 183.126 209.474 105.016 1.00 124.33 ? 372 GLN B CA  1 
ATOM   2467 C  C   . GLN A 1 379 ? 184.641 209.600 105.085 1.00 124.52 ? 372 GLN B C   1 
ATOM   2468 O  O   . GLN A 1 379 ? 185.143 210.563 105.671 1.00 123.03 ? 372 GLN B O   1 
ATOM   2469 C  CB  . GLN A 1 379 ? 182.591 208.955 106.351 1.00 122.13 ? 372 GLN B CB  1 
ATOM   2470 C  CG  . GLN A 1 379 ? 182.946 207.507 106.645 1.00 122.49 ? 372 GLN B CG  1 
ATOM   2471 C  CD  . GLN A 1 379 ? 181.808 206.553 106.344 1.00 122.51 ? 372 GLN B CD  1 
ATOM   2472 O  OE1 . GLN A 1 379 ? 180.762 206.957 105.838 1.00 122.99 ? 372 GLN B OE1 1 
ATOM   2473 N  NE2 . GLN A 1 379 ? 182.007 205.278 106.653 1.00 115.75 ? 372 GLN B NE2 1 
ATOM   2474 N  N   . CYS A 1 380 ? 185.377 208.656 104.494 1.00 126.02 ? 373 CYS B N   1 
ATOM   2475 C  CA  . CYS A 1 380 ? 186.834 208.702 104.515 1.00 124.99 ? 373 CYS B CA  1 
ATOM   2476 C  C   . CYS A 1 380 ? 187.399 209.843 103.684 1.00 124.47 ? 373 CYS B C   1 
ATOM   2477 O  O   . CYS A 1 380 ? 188.594 210.134 103.795 1.00 123.51 ? 373 CYS B O   1 
ATOM   2478 C  CB  . CYS A 1 380 ? 187.410 207.376 104.012 1.00 121.58 ? 373 CYS B CB  1 
ATOM   2479 S  SG  . CYS A 1 380 ? 187.262 205.991 105.160 1.00 122.53 ? 373 CYS B SG  1 
ATOM   2480 N  N   . ASP A 1 381 ? 186.579 210.492 102.860 1.00 122.86 ? 374 ASP B N   1 
ATOM   2481 C  CA  . ASP A 1 381 ? 187.084 211.544 101.987 1.00 124.66 ? 374 ASP B CA  1 
ATOM   2482 C  C   . ASP A 1 381 ? 187.292 212.849 102.746 1.00 124.69 ? 374 ASP B C   1 
ATOM   2483 O  O   . ASP A 1 381 ? 188.343 213.484 102.625 1.00 124.34 ? 374 ASP B O   1 
ATOM   2484 C  CB  . ASP A 1 381 ? 186.126 211.750 100.813 1.00 124.70 ? 374 ASP B CB  1 
ATOM   2485 C  CG  . ASP A 1 381 ? 186.281 210.687 99.742  1.00 121.75 ? 374 ASP B CG  1 
ATOM   2486 O  OD1 . ASP A 1 381 ? 186.869 209.625 100.036 1.00 119.14 ? 374 ASP B OD1 1 
ATOM   2487 O  OD2 . ASP A 1 381 ? 185.812 210.912 98.607  1.00 119.27 ? 374 ASP B OD2 1 
ATOM   2488 N  N   . CYS A 1 382 ? 186.304 213.266 103.534 1.00 125.66 ? 375 CYS B N   1 
ATOM   2489 C  CA  . CYS A 1 382 ? 186.360 214.551 104.231 1.00 126.40 ? 375 CYS B CA  1 
ATOM   2490 C  C   . CYS A 1 382 ? 187.013 214.347 105.591 1.00 126.01 ? 375 CYS B C   1 
ATOM   2491 O  O   . CYS A 1 382 ? 186.361 214.408 106.634 1.00 126.54 ? 375 CYS B O   1 
ATOM   2492 C  CB  . CYS A 1 382 ? 184.967 215.150 104.362 1.00 131.69 ? 375 CYS B CB  1 
ATOM   2493 S  SG  . CYS A 1 382 ? 183.654 213.933 104.621 1.00 143.77 ? 375 CYS B SG  1 
ATOM   2494 N  N   . ILE A 1 383 ? 188.324 214.103 105.583 1.00 125.70 ? 376 ILE B N   1 
ATOM   2495 C  CA  . ILE A 1 383 ? 189.080 213.911 106.816 1.00 125.29 ? 376 ILE B CA  1 
ATOM   2496 C  C   . ILE A 1 383 ? 190.331 214.769 106.746 1.00 126.10 ? 376 ILE B C   1 
ATOM   2497 O  O   . ILE A 1 383 ? 190.681 215.298 105.688 1.00 125.50 ? 376 ILE B O   1 
ATOM   2498 C  CB  . ILE A 1 383 ? 189.441 212.422 107.047 1.00 119.74 ? 376 ILE B CB  1 
ATOM   2499 C  CG1 . ILE A 1 383 ? 190.678 212.054 106.230 1.00 116.68 ? 376 ILE B CG1 1 
ATOM   2500 C  CG2 . ILE A 1 383 ? 188.273 211.513 106.711 1.00 118.93 ? 376 ILE B CG2 1 
ATOM   2501 C  CD1 . ILE A 1 383 ? 191.545 211.020 106.884 1.00 113.96 ? 376 ILE B CD1 1 
ATOM   2502 N  N   . THR A 1 384 ? 191.002 214.911 107.883 1.00 124.75 ? 377 THR B N   1 
ATOM   2503 C  CA  . THR A 1 384 ? 192.287 215.583 107.978 1.00 121.03 ? 377 THR B CA  1 
ATOM   2504 C  C   . THR A 1 384 ? 193.251 214.737 108.799 1.00 118.21 ? 377 THR B C   1 
ATOM   2505 O  O   . THR A 1 384 ? 192.866 213.756 109.439 1.00 117.60 ? 377 THR B O   1 
ATOM   2506 C  CB  . THR A 1 384 ? 192.135 216.974 108.602 1.00 122.16 ? 377 THR B CB  1 
ATOM   2507 O  OG1 . THR A 1 384 ? 191.150 216.928 109.642 1.00 123.48 ? 377 THR B OG1 1 
ATOM   2508 C  CG2 . THR A 1 384 ? 191.712 217.986 107.549 1.00 116.90 ? 377 THR B CG2 1 
ATOM   2509 N  N   . LEU A 1 385 ? 194.524 215.140 108.777 1.00 115.97 ? 378 LEU B N   1 
ATOM   2510 C  CA  . LEU A 1 385 ? 195.555 214.388 109.485 1.00 113.81 ? 378 LEU B CA  1 
ATOM   2511 C  C   . LEU A 1 385 ? 195.312 214.366 110.987 1.00 116.62 ? 378 LEU B C   1 
ATOM   2512 O  O   . LEU A 1 385 ? 195.702 213.407 111.665 1.00 117.83 ? 378 LEU B O   1 
ATOM   2513 C  CB  . LEU A 1 385 ? 196.931 214.974 109.160 1.00 114.09 ? 378 LEU B CB  1 
ATOM   2514 C  CG  . LEU A 1 385 ? 197.237 216.432 109.531 1.00 119.80 ? 378 LEU B CG  1 
ATOM   2515 C  CD1 . LEU A 1 385 ? 197.680 216.608 110.983 1.00 114.14 ? 378 LEU B CD1 1 
ATOM   2516 C  CD2 . LEU A 1 385 ? 198.270 217.021 108.578 1.00 123.36 ? 378 LEU B CD2 1 
ATOM   2517 N  N   . GLN A 1 386 ? 194.673 215.406 111.525 1.00 118.35 ? 379 GLN B N   1 
ATOM   2518 C  CA  . GLN A 1 386 ? 194.404 215.447 112.956 1.00 121.69 ? 379 GLN B CA  1 
ATOM   2519 C  C   . GLN A 1 386 ? 193.333 214.448 113.371 1.00 120.53 ? 379 GLN B C   1 
ATOM   2520 O  O   . GLN A 1 386 ? 193.257 214.097 114.552 1.00 118.26 ? 379 GLN B O   1 
ATOM   2521 C  CB  . GLN A 1 386 ? 193.992 216.858 113.376 1.00 121.77 ? 379 GLN B CB  1 
ATOM   2522 C  CG  . GLN A 1 386 ? 192.889 217.463 112.528 1.00 120.86 ? 379 GLN B CG  1 
ATOM   2523 C  CD  . GLN A 1 386 ? 192.388 218.779 113.085 1.00 120.60 ? 379 GLN B CD  1 
ATOM   2524 O  OE1 . GLN A 1 386 ? 193.097 219.785 113.066 1.00 121.65 ? 379 GLN B OE1 1 
ATOM   2525 N  NE2 . GLN A 1 386 ? 191.158 218.779 113.587 1.00 120.36 ? 379 GLN B NE2 1 
ATOM   2526 N  N   . ASN A 1 387 ? 192.512 213.980 112.432 1.00 118.90 ? 380 ASN B N   1 
ATOM   2527 C  CA  . ASN A 1 387 ? 191.480 213.007 112.757 1.00 115.55 ? 380 ASN B CA  1 
ATOM   2528 C  C   . ASN A 1 387 ? 192.021 211.593 112.904 1.00 114.25 ? 380 ASN B C   1 
ATOM   2529 O  O   . ASN A 1 387 ? 191.299 210.721 113.397 1.00 113.76 ? 380 ASN B O   1 
ATOM   2530 C  CB  . ASN A 1 387 ? 190.380 213.030 111.696 1.00 117.15 ? 380 ASN B CB  1 
ATOM   2531 C  CG  . ASN A 1 387 ? 189.214 213.903 112.097 1.00 123.24 ? 380 ASN B CG  1 
ATOM   2532 O  OD1 . ASN A 1 387 ? 188.729 213.817 113.224 1.00 126.44 ? 380 ASN B OD1 1 
ATOM   2533 N  ND2 . ASN A 1 387 ? 188.756 214.750 111.180 1.00 122.41 ? 380 ASN B ND2 1 
ATOM   2534 N  N   . VAL A 1 388 ? 193.265 211.343 112.491 1.00 114.55 ? 381 VAL B N   1 
ATOM   2535 C  CA  . VAL A 1 388 ? 193.890 210.036 112.646 1.00 108.68 ? 381 VAL B CA  1 
ATOM   2536 C  C   . VAL A 1 388 ? 195.227 210.110 113.362 1.00 108.19 ? 381 VAL B C   1 
ATOM   2537 O  O   . VAL A 1 388 ? 195.848 209.073 113.590 1.00 108.55 ? 381 VAL B O   1 
ATOM   2538 C  CB  . VAL A 1 388 ? 194.062 209.330 111.286 1.00 103.19 ? 381 VAL B CB  1 
ATOM   2539 C  CG1 . VAL A 1 388 ? 192.727 209.195 110.583 1.00 102.93 ? 381 VAL B CG1 1 
ATOM   2540 C  CG2 . VAL A 1 388 ? 195.054 210.082 110.424 1.00 104.39 ? 381 VAL B CG2 1 
ATOM   2541 N  N   . SER A 1 389 ? 195.697 211.305 113.723 1.00 107.82 ? 382 SER B N   1 
ATOM   2542 C  CA  . SER A 1 389 ? 196.999 211.428 114.366 1.00 108.73 ? 382 SER B CA  1 
ATOM   2543 C  C   . SER A 1 389 ? 197.059 210.730 115.718 1.00 107.80 ? 382 SER B C   1 
ATOM   2544 O  O   . SER A 1 389 ? 198.154 210.381 116.171 1.00 106.37 ? 382 SER B O   1 
ATOM   2545 C  CB  . SER A 1 389 ? 197.355 212.901 114.546 1.00 113.65 ? 382 SER B CB  1 
ATOM   2546 O  OG  . SER A 1 389 ? 196.492 213.513 115.489 1.00 112.15 ? 382 SER B OG  1 
ATOM   2547 N  N   . ALA A 1 390 ? 195.917 210.528 116.375 1.00 109.66 ? 383 ALA B N   1 
ATOM   2548 C  CA  . ALA A 1 390 ? 195.934 209.967 117.722 1.00 111.96 ? 383 ALA B CA  1 
ATOM   2549 C  C   . ALA A 1 390 ? 196.376 208.509 117.722 1.00 109.47 ? 383 ALA B C   1 
ATOM   2550 O  O   . ALA A 1 390 ? 197.190 208.102 118.559 1.00 102.98 ? 383 ALA B O   1 
ATOM   2551 C  CB  . ALA A 1 390 ? 194.554 210.106 118.363 1.00 109.04 ? 383 ALA B CB  1 
ATOM   2552 N  N   . GLY A 1 391 ? 195.864 207.713 116.791 1.00 108.50 ? 384 GLY B N   1 
ATOM   2553 C  CA  . GLY A 1 391 ? 196.109 206.285 116.802 1.00 103.40 ? 384 GLY B CA  1 
ATOM   2554 C  C   . GLY A 1 391 ? 197.295 205.855 115.967 1.00 100.85 ? 384 GLY B C   1 
ATOM   2555 O  O   . GLY A 1 391 ? 197.385 204.695 115.558 1.00 99.86  ? 384 GLY B O   1 
ATOM   2556 N  N   . LEU A 1 392 ? 198.208 206.788 115.696 1.00 99.63  ? 385 LEU B N   1 
ATOM   2557 C  CA  . LEU A 1 392 ? 199.354 206.475 114.848 1.00 96.75  ? 385 LEU B CA  1 
ATOM   2558 C  C   . LEU A 1 392 ? 200.229 205.396 115.473 1.00 96.43  ? 385 LEU B C   1 
ATOM   2559 O  O   . LEU A 1 392 ? 200.673 204.472 114.784 1.00 96.19  ? 385 LEU B O   1 
ATOM   2560 C  CB  . LEU A 1 392 ? 200.161 207.745 114.588 1.00 97.38  ? 385 LEU B CB  1 
ATOM   2561 C  CG  . LEU A 1 392 ? 199.829 208.487 113.293 1.00 97.60  ? 385 LEU B CG  1 
ATOM   2562 C  CD1 . LEU A 1 392 ? 200.946 209.441 112.922 1.00 97.20  ? 385 LEU B CD1 1 
ATOM   2563 C  CD2 . LEU A 1 392 ? 199.566 207.507 112.164 1.00 92.56  ? 385 LEU B CD2 1 
ATOM   2564 N  N   . ASN A 1 393 ? 200.480 205.489 116.777 1.00 97.99  ? 386 ASN B N   1 
ATOM   2565 C  CA  . ASN A 1 393 ? 201.286 204.491 117.481 1.00 98.17  ? 386 ASN B CA  1 
ATOM   2566 C  C   . ASN A 1 393 ? 200.367 203.413 118.058 1.00 94.44  ? 386 ASN B C   1 
ATOM   2567 O  O   . ASN A 1 393 ? 200.248 203.221 119.268 1.00 94.63  ? 386 ASN B O   1 
ATOM   2568 C  CB  . ASN A 1 393 ? 202.125 205.152 118.568 1.00 98.46  ? 386 ASN B CB  1 
ATOM   2569 C  CG  . ASN A 1 393 ? 202.854 206.383 118.076 1.00 99.67  ? 386 ASN B CG  1 
ATOM   2570 O  OD1 . ASN A 1 393 ? 202.391 207.506 118.261 1.00 98.91  ? 386 ASN B OD1 1 
ATOM   2571 N  ND2 . ASN A 1 393 ? 204.005 206.179 117.450 1.00 102.58 ? 386 ASN B ND2 1 
ATOM   2572 N  N   . HIS A 1 394 ? 199.714 202.697 117.151 1.00 92.01  ? 387 HIS B N   1 
ATOM   2573 C  CA  . HIS A 1 394 ? 198.791 201.630 117.505 1.00 90.46  ? 387 HIS B CA  1 
ATOM   2574 C  C   . HIS A 1 394 ? 199.472 200.283 117.315 1.00 92.12  ? 387 HIS B C   1 
ATOM   2575 O  O   . HIS A 1 394 ? 200.239 200.095 116.366 1.00 94.41  ? 387 HIS B O   1 
ATOM   2576 C  CB  . HIS A 1 394 ? 197.520 201.696 116.657 1.00 86.57  ? 387 HIS B CB  1 
ATOM   2577 C  CG  . HIS A 1 394 ? 196.332 201.054 117.298 1.00 88.38  ? 387 HIS B CG  1 
ATOM   2578 N  ND1 . HIS A 1 394 ? 196.391 200.450 118.535 1.00 91.02  ? 387 HIS B ND1 1 
ATOM   2579 C  CD2 . HIS A 1 394 ? 195.055 200.917 116.874 1.00 87.71  ? 387 HIS B CD2 1 
ATOM   2580 C  CE1 . HIS A 1 394 ? 195.201 199.970 118.846 1.00 91.88  ? 387 HIS B CE1 1 
ATOM   2581 N  NE2 . HIS A 1 394 ? 194.372 200.240 117.854 1.00 91.77  ? 387 HIS B NE2 1 
ATOM   2582 N  N   . HIS A 1 395 ? 199.199 199.350 118.226 1.00 89.62  ? 388 HIS B N   1 
ATOM   2583 C  CA  . HIS A 1 395 ? 199.836 198.041 118.138 1.00 89.47  ? 388 HIS B CA  1 
ATOM   2584 C  C   . HIS A 1 395 ? 199.297 197.237 116.962 1.00 83.43  ? 388 HIS B C   1 
ATOM   2585 O  O   . HIS A 1 395 ? 200.059 196.549 116.275 1.00 78.59  ? 388 HIS B O   1 
ATOM   2586 C  CB  . HIS A 1 395 ? 199.645 197.272 119.445 1.00 91.15  ? 388 HIS B CB  1 
ATOM   2587 C  CG  . HIS A 1 395 ? 198.380 197.613 120.169 1.00 94.93  ? 388 HIS B CG  1 
ATOM   2588 N  ND1 . HIS A 1 395 ? 198.273 198.698 121.011 1.00 99.44  ? 388 HIS B ND1 1 
ATOM   2589 C  CD2 . HIS A 1 395 ? 197.169 197.007 120.181 1.00 94.48  ? 388 HIS B CD2 1 
ATOM   2590 C  CE1 . HIS A 1 395 ? 197.050 198.749 121.508 1.00 98.35  ? 388 HIS B CE1 1 
ATOM   2591 N  NE2 . HIS A 1 395 ? 196.360 197.734 121.020 1.00 96.55  ? 388 HIS B NE2 1 
ATOM   2592 N  N   . GLN A 1 396 ? 197.990 197.326 116.701 1.00 81.43  ? 389 GLN B N   1 
ATOM   2593 C  CA  . GLN A 1 396 ? 197.362 196.474 115.697 1.00 76.29  ? 389 GLN B CA  1 
ATOM   2594 C  C   . GLN A 1 396 ? 197.857 196.759 114.286 1.00 75.37  ? 389 GLN B C   1 
ATOM   2595 O  O   . GLN A 1 396 ? 197.643 195.932 113.391 1.00 78.60  ? 389 GLN B O   1 
ATOM   2596 C  CB  . GLN A 1 396 ? 195.845 196.633 115.749 1.00 78.07  ? 389 GLN B CB  1 
ATOM   2597 C  CG  . GLN A 1 396 ? 195.249 196.449 117.126 1.00 81.93  ? 389 GLN B CG  1 
ATOM   2598 C  CD  . GLN A 1 396 ? 195.127 194.996 117.510 1.00 82.66  ? 389 GLN B CD  1 
ATOM   2599 O  OE1 . GLN A 1 396 ? 195.041 194.122 116.650 1.00 80.08  ? 389 GLN B OE1 1 
ATOM   2600 N  NE2 . GLN A 1 396 ? 195.114 194.725 118.809 1.00 84.41  ? 389 GLN B NE2 1 
ATOM   2601 N  N   . THR A 1 397 ? 198.498 197.906 114.058 1.00 73.39  ? 390 THR B N   1 
ATOM   2602 C  CA  . THR A 1 397 ? 199.064 198.165 112.741 1.00 73.21  ? 390 THR B CA  1 
ATOM   2603 C  C   . THR A 1 397 ? 200.120 197.126 112.395 1.00 72.70  ? 390 THR B C   1 
ATOM   2604 O  O   . THR A 1 397 ? 200.160 196.618 111.267 1.00 71.29  ? 390 THR B O   1 
ATOM   2605 C  CB  . THR A 1 397 ? 199.651 199.574 112.681 1.00 74.19  ? 390 THR B CB  1 
ATOM   2606 O  OG1 . THR A 1 397 ? 200.800 199.652 113.530 1.00 79.18  ? 390 THR B OG1 1 
ATOM   2607 C  CG2 . THR A 1 397 ? 198.624 200.593 113.135 1.00 75.91  ? 390 THR B CG2 1 
ATOM   2608 N  N   . PHE A 1 398 ? 200.969 196.774 113.362 1.00 71.88  ? 391 PHE B N   1 
ATOM   2609 C  CA  . PHE A 1 398 ? 201.938 195.714 113.120 1.00 67.63  ? 391 PHE B CA  1 
ATOM   2610 C  C   . PHE A 1 398 ? 201.250 194.379 112.899 1.00 67.62  ? 391 PHE B C   1 
ATOM   2611 O  O   . PHE A 1 398 ? 201.724 193.558 112.111 1.00 70.40  ? 391 PHE B O   1 
ATOM   2612 C  CB  . PHE A 1 398 ? 202.923 195.598 114.277 1.00 72.00  ? 391 PHE B CB  1 
ATOM   2613 C  CG  . PHE A 1 398 ? 203.892 194.467 114.116 1.00 71.00  ? 391 PHE B CG  1 
ATOM   2614 C  CD1 . PHE A 1 398 ? 205.027 194.622 113.348 1.00 73.59  ? 391 PHE B CD1 1 
ATOM   2615 C  CD2 . PHE A 1 398 ? 203.655 193.240 114.707 1.00 68.51  ? 391 PHE B CD2 1 
ATOM   2616 C  CE1 . PHE A 1 398 ? 205.913 193.585 113.190 1.00 75.50  ? 391 PHE B CE1 1 
ATOM   2617 C  CE2 . PHE A 1 398 ? 204.539 192.199 114.547 1.00 70.61  ? 391 PHE B CE2 1 
ATOM   2618 C  CZ  . PHE A 1 398 ? 205.669 192.372 113.788 1.00 74.73  ? 391 PHE B CZ  1 
ATOM   2619 N  N   . SER A 1 399 ? 200.151 194.123 113.606 1.00 67.93  ? 392 SER B N   1 
ATOM   2620 C  CA  . SER A 1 399 ? 199.445 192.864 113.407 1.00 65.11  ? 392 SER B CA  1 
ATOM   2621 C  C   . SER A 1 399 ? 198.930 192.749 111.981 1.00 63.86  ? 392 SER B C   1 
ATOM   2622 O  O   . SER A 1 399 ? 199.075 191.702 111.342 1.00 67.90  ? 392 SER B O   1 
ATOM   2623 C  CB  . SER A 1 399 ? 198.299 192.738 114.407 1.00 65.23  ? 392 SER B CB  1 
ATOM   2624 O  OG  . SER A 1 399 ? 198.794 192.546 115.719 1.00 73.04  ? 392 SER B OG  1 
ATOM   2625 N  N   . VAL A 1 400 ? 198.348 193.827 111.457 1.00 61.68  ? 393 VAL B N   1 
ATOM   2626 C  CA  . VAL A 1 400 ? 197.869 193.812 110.077 1.00 58.00  ? 393 VAL B CA  1 
ATOM   2627 C  C   . VAL A 1 400 ? 199.032 193.658 109.107 1.00 61.09  ? 393 VAL B C   1 
ATOM   2628 O  O   . VAL A 1 400 ? 198.950 192.908 108.123 1.00 66.13  ? 393 VAL B O   1 
ATOM   2629 C  CB  . VAL A 1 400 ? 197.059 195.082 109.776 1.00 54.83  ? 393 VAL B CB  1 
ATOM   2630 C  CG1 . VAL A 1 400 ? 196.603 195.069 108.344 1.00 58.02  ? 393 VAL B CG1 1 
ATOM   2631 C  CG2 . VAL A 1 400 ? 195.875 195.171 110.700 1.00 59.92  ? 393 VAL B CG2 1 
ATOM   2632 N  N   . TYR A 1 401 ? 200.128 194.376 109.359 1.00 61.09  ? 394 TYR B N   1 
ATOM   2633 C  CA  . TYR A 1 401 ? 201.292 194.296 108.484 1.00 61.15  ? 394 TYR B CA  1 
ATOM   2634 C  C   . TYR A 1 401 ? 201.843 192.876 108.438 1.00 60.59  ? 394 TYR B C   1 
ATOM   2635 O  O   . TYR A 1 401 ? 202.141 192.347 107.360 1.00 64.81  ? 394 TYR B O   1 
ATOM   2636 C  CB  . TYR A 1 401 ? 202.340 195.292 108.975 1.00 64.32  ? 394 TYR B CB  1 
ATOM   2637 C  CG  . TYR A 1 401 ? 203.703 195.207 108.345 1.00 64.33  ? 394 TYR B CG  1 
ATOM   2638 C  CD1 . TYR A 1 401 ? 203.984 195.880 107.170 1.00 68.47  ? 394 TYR B CD1 1 
ATOM   2639 C  CD2 . TYR A 1 401 ? 204.721 194.494 108.948 1.00 66.80  ? 394 TYR B CD2 1 
ATOM   2640 C  CE1 . TYR A 1 401 ? 205.232 195.822 106.600 1.00 71.72  ? 394 TYR B CE1 1 
ATOM   2641 C  CE2 . TYR A 1 401 ? 205.971 194.431 108.387 1.00 69.32  ? 394 TYR B CE2 1 
ATOM   2642 C  CZ  . TYR A 1 401 ? 206.221 195.094 107.213 1.00 73.16  ? 394 TYR B CZ  1 
ATOM   2643 O  OH  . TYR A 1 401 ? 207.473 195.027 106.652 1.00 76.54  ? 394 TYR B OH  1 
ATOM   2644 N  N   . ALA A 1 402 ? 201.942 192.228 109.597 1.00 59.73  ? 395 ALA B N   1 
ATOM   2645 C  CA  . ALA A 1 402 ? 202.433 190.860 109.651 1.00 60.63  ? 395 ALA B CA  1 
ATOM   2646 C  C   . ALA A 1 402 ? 201.456 189.882 109.019 1.00 62.28  ? 395 ALA B C   1 
ATOM   2647 O  O   . ALA A 1 402 ? 201.884 188.898 108.417 1.00 66.86  ? 395 ALA B O   1 
ATOM   2648 C  CB  . ALA A 1 402 ? 202.718 190.459 111.095 1.00 60.03  ? 395 ALA B CB  1 
ATOM   2649 N  N   . ALA A 1 403 ? 200.151 190.117 109.151 1.00 59.10  ? 396 ALA B N   1 
ATOM   2650 C  CA  . ALA A 1 403 ? 199.186 189.241 108.494 1.00 56.16  ? 396 ALA B CA  1 
ATOM   2651 C  C   . ALA A 1 403 ? 199.328 189.302 106.979 1.00 58.63  ? 396 ALA B C   1 
ATOM   2652 O  O   . ALA A 1 403 ? 199.325 188.265 106.298 1.00 58.94  ? 396 ALA B O   1 
ATOM   2653 C  CB  . ALA A 1 403 ? 197.770 189.618 108.915 1.00 54.14  ? 396 ALA B CB  1 
ATOM   2654 N  N   . VAL A 1 404 ? 199.461 190.513 106.434 1.00 59.77  ? 397 VAL B N   1 
ATOM   2655 C  CA  . VAL A 1 404 ? 199.655 190.654 104.993 1.00 58.10  ? 397 VAL B CA  1 
ATOM   2656 C  C   . VAL A 1 404 ? 200.953 189.986 104.565 1.00 64.33  ? 397 VAL B C   1 
ATOM   2657 O  O   . VAL A 1 404 ? 201.003 189.287 103.544 1.00 67.88  ? 397 VAL B O   1 
ATOM   2658 C  CB  . VAL A 1 404 ? 199.622 192.136 104.587 1.00 57.85  ? 397 VAL B CB  1 
ATOM   2659 C  CG1 . VAL A 1 404 ? 200.240 192.317 103.225 1.00 63.42  ? 397 VAL B CG1 1 
ATOM   2660 C  CG2 . VAL A 1 404 ? 198.201 192.639 104.584 1.00 59.29  ? 397 VAL B CG2 1 
ATOM   2661 N  N   . TYR A 1 405 ? 202.021 190.180 105.342 1.00 61.75  ? 398 TYR B N   1 
ATOM   2662 C  CA  . TYR A 1 405 ? 203.290 189.544 105.008 1.00 58.05  ? 398 TYR B CA  1 
ATOM   2663 C  C   . TYR A 1 405 ? 203.173 188.027 105.048 1.00 59.45  ? 398 TYR B C   1 
ATOM   2664 O  O   . TYR A 1 405 ? 203.772 187.331 104.225 1.00 62.38  ? 398 TYR B O   1 
ATOM   2665 C  CB  . TYR A 1 405 ? 204.378 190.017 105.962 1.00 56.51  ? 398 TYR B CB  1 
ATOM   2666 C  CG  . TYR A 1 405 ? 205.395 190.915 105.321 1.00 57.58  ? 398 TYR B CG  1 
ATOM   2667 C  CD1 . TYR A 1 405 ? 205.122 192.253 105.105 1.00 58.82  ? 398 TYR B CD1 1 
ATOM   2668 C  CD2 . TYR A 1 405 ? 206.630 190.431 104.940 1.00 62.71  ? 398 TYR B CD2 1 
ATOM   2669 C  CE1 . TYR A 1 405 ? 206.047 193.083 104.526 1.00 63.03  ? 398 TYR B CE1 1 
ATOM   2670 C  CE2 . TYR A 1 405 ? 207.564 191.255 104.360 1.00 68.28  ? 398 TYR B CE2 1 
ATOM   2671 C  CZ  . TYR A 1 405 ? 207.267 192.581 104.156 1.00 67.40  ? 398 TYR B CZ  1 
ATOM   2672 O  OH  . TYR A 1 405 ? 208.198 193.406 103.575 1.00 71.87  ? 398 TYR B OH  1 
ATOM   2673 N  N   . SER A 1 406 ? 202.413 187.497 106.005 1.00 58.31  ? 399 SER B N   1 
ATOM   2674 C  CA  . SER A 1 406 ? 202.247 186.053 106.109 1.00 61.91  ? 399 SER B CA  1 
ATOM   2675 C  C   . SER A 1 406 ? 201.511 185.495 104.904 1.00 62.47  ? 399 SER B C   1 
ATOM   2676 O  O   . SER A 1 406 ? 201.897 184.454 104.361 1.00 65.76  ? 399 SER B O   1 
ATOM   2677 C  CB  . SER A 1 406 ? 201.504 185.702 107.394 1.00 62.87  ? 399 SER B CB  1 
ATOM   2678 O  OG  . SER A 1 406 ? 200.106 185.668 107.182 1.00 69.02  ? 399 SER B OG  1 
ATOM   2679 N  N   . VAL A 1 407 ? 200.443 186.166 104.470 1.00 61.36  ? 400 VAL B N   1 
ATOM   2680 C  CA  . VAL A 1 407 ? 199.725 185.678 103.295 1.00 59.12  ? 400 VAL B CA  1 
ATOM   2681 C  C   . VAL A 1 407 ? 200.612 185.765 102.061 1.00 59.12  ? 400 VAL B C   1 
ATOM   2682 O  O   . VAL A 1 407 ? 200.609 184.867 101.212 1.00 62.51  ? 400 VAL B O   1 
ATOM   2683 C  CB  . VAL A 1 407 ? 198.403 186.439 103.097 1.00 54.88  ? 400 VAL B CB  1 
ATOM   2684 C  CG1 . VAL A 1 407 ? 197.751 186.004 101.808 1.00 49.62  ? 400 VAL B CG1 1 
ATOM   2685 C  CG2 . VAL A 1 407 ? 197.471 186.182 104.258 1.00 56.35  ? 400 VAL B CG2 1 
ATOM   2686 N  N   . ALA A 1 408 ? 201.395 186.839 101.946 1.00 56.41  ? 401 ALA B N   1 
ATOM   2687 C  CA  . ALA A 1 408 ? 202.303 186.958 100.811 1.00 58.30  ? 401 ALA B CA  1 
ATOM   2688 C  C   . ALA A 1 408 ? 203.350 185.854 100.821 1.00 65.49  ? 401 ALA B C   1 
ATOM   2689 O  O   . ALA A 1 408 ? 203.676 185.292 99.771  1.00 73.69  ? 401 ALA B O   1 
ATOM   2690 C  CB  . ALA A 1 408 ? 202.975 188.325 100.812 1.00 58.02  ? 401 ALA B CB  1 
ATOM   2691 N  N   . GLN A 1 409 ? 203.894 185.532 101.994 1.00 62.09  ? 402 GLN B N   1 
ATOM   2692 C  CA  . GLN A 1 409 ? 204.888 184.467 102.078 1.00 60.72  ? 402 GLN B CA  1 
ATOM   2693 C  C   . GLN A 1 409 ? 204.278 183.114 101.753 1.00 65.03  ? 402 GLN B C   1 
ATOM   2694 O  O   . GLN A 1 409 ? 204.916 182.280 101.103 1.00 70.22  ? 402 GLN B O   1 
ATOM   2695 C  CB  . GLN A 1 409 ? 205.522 184.440 103.462 1.00 60.83  ? 402 GLN B CB  1 
ATOM   2696 C  CG  . GLN A 1 409 ? 206.704 183.515 103.544 1.00 66.32  ? 402 GLN B CG  1 
ATOM   2697 C  CD  . GLN A 1 409 ? 207.865 184.000 102.713 1.00 72.52  ? 402 GLN B CD  1 
ATOM   2698 O  OE1 . GLN A 1 409 ? 208.327 185.128 102.872 1.00 72.96  ? 402 GLN B OE1 1 
ATOM   2699 N  NE2 . GLN A 1 409 ? 208.344 183.151 101.814 1.00 72.25  ? 402 GLN B NE2 1 
ATOM   2700 N  N   . ALA A 1 410 ? 203.048 182.871 102.206 1.00 64.64  ? 403 ALA B N   1 
ATOM   2701 C  CA  . ALA A 1 410 ? 202.373 181.624 101.868 1.00 65.04  ? 403 ALA B CA  1 
ATOM   2702 C  C   . ALA A 1 410 ? 202.142 181.515 100.369 1.00 65.85  ? 403 ALA B C   1 
ATOM   2703 O  O   . ALA A 1 410 ? 202.301 180.438 99.787  1.00 67.98  ? 403 ALA B O   1 
ATOM   2704 C  CB  . ALA A 1 410 ? 201.051 181.518 102.621 1.00 68.22  ? 403 ALA B CB  1 
ATOM   2705 N  N   . LEU A 1 411 ? 201.754 182.620 99.728  1.00 66.82  ? 404 LEU B N   1 
ATOM   2706 C  CA  . LEU A 1 411 ? 201.584 182.612 98.278  1.00 68.12  ? 404 LEU B CA  1 
ATOM   2707 C  C   . LEU A 1 411 ? 202.908 182.379 97.563  1.00 74.06  ? 404 LEU B C   1 
ATOM   2708 O  O   . LEU A 1 411 ? 202.961 181.666 96.555  1.00 80.59  ? 404 LEU B O   1 
ATOM   2709 C  CB  . LEU A 1 411 ? 200.953 183.919 97.812  1.00 63.65  ? 404 LEU B CB  1 
ATOM   2710 C  CG  . LEU A 1 411 ? 200.841 184.049 96.298  1.00 66.73  ? 404 LEU B CG  1 
ATOM   2711 C  CD1 . LEU A 1 411 ? 199.968 182.944 95.754  1.00 73.69  ? 404 LEU B CD1 1 
ATOM   2712 C  CD2 . LEU A 1 411 ? 200.288 185.406 95.920  1.00 73.74  ? 404 LEU B CD2 1 
ATOM   2713 N  N   . HIS A 1 412 ? 203.986 182.985 98.060  1.00 71.57  ? 405 HIS B N   1 
ATOM   2714 C  CA  . HIS A 1 412 ? 205.300 182.767 97.465  1.00 71.93  ? 405 HIS B CA  1 
ATOM   2715 C  C   . HIS A 1 412 ? 205.726 181.310 97.589  1.00 76.07  ? 405 HIS B C   1 
ATOM   2716 O  O   . HIS A 1 412 ? 206.305 180.743 96.657  1.00 82.29  ? 405 HIS B O   1 
ATOM   2717 C  CB  . HIS A 1 412 ? 206.322 183.686 98.126  1.00 78.59  ? 405 HIS B CB  1 
ATOM   2718 C  CG  . HIS A 1 412 ? 207.742 183.356 97.795  1.00 88.11  ? 405 HIS B CG  1 
ATOM   2719 N  ND1 . HIS A 1 412 ? 208.321 183.684 96.589  1.00 92.23  ? 405 HIS B ND1 1 
ATOM   2720 C  CD2 . HIS A 1 412 ? 208.706 182.742 98.519  1.00 87.71  ? 405 HIS B CD2 1 
ATOM   2721 C  CE1 . HIS A 1 412 ? 209.578 183.280 96.581  1.00 94.26  ? 405 HIS B CE1 1 
ATOM   2722 N  NE2 . HIS A 1 412 ? 209.837 182.704 97.741  1.00 91.99  ? 405 HIS B NE2 1 
ATOM   2723 N  N   . ASN A 1 413 ? 205.456 180.691 98.738  1.00 73.15  ? 406 ASN B N   1 
ATOM   2724 C  CA  . ASN A 1 413 ? 205.799 179.286 98.918  1.00 74.90  ? 406 ASN B CA  1 
ATOM   2725 C  C   . ASN A 1 413 ? 204.945 178.384 98.039  1.00 77.72  ? 406 ASN B C   1 
ATOM   2726 O  O   . ASN A 1 413 ? 205.444 177.402 97.481  1.00 83.66  ? 406 ASN B O   1 
ATOM   2727 C  CB  . ASN A 1 413 ? 205.643 178.890 100.384 1.00 75.66  ? 406 ASN B CB  1 
ATOM   2728 C  CG  . ASN A 1 413 ? 206.915 179.068 101.171 1.00 77.65  ? 406 ASN B CG  1 
ATOM   2729 O  OD1 . ASN A 1 413 ? 207.905 179.587 100.660 1.00 77.45  ? 406 ASN B OD1 1 
ATOM   2730 N  ND2 . ASN A 1 413 ? 206.899 178.635 102.425 1.00 79.15  ? 406 ASN B ND2 1 
ATOM   2731 N  N   . THR A 1 414 ? 203.652 178.693 97.915  1.00 74.94  ? 407 THR B N   1 
ATOM   2732 C  CA  . THR A 1 414 ? 202.754 177.826 97.159  1.00 76.62  ? 407 THR B CA  1 
ATOM   2733 C  C   . THR A 1 414 ? 203.158 177.755 95.693  1.00 80.80  ? 407 THR B C   1 
ATOM   2734 O  O   . THR A 1 414 ? 203.171 176.672 95.097  1.00 87.11  ? 407 THR B O   1 
ATOM   2735 C  CB  . THR A 1 414 ? 201.312 178.310 97.303  1.00 76.05  ? 407 THR B CB  1 
ATOM   2736 O  OG1 . THR A 1 414 ? 200.769 177.825 98.535  1.00 75.74  ? 407 THR B OG1 1 
ATOM   2737 C  CG2 . THR A 1 414 ? 200.459 177.806 96.160  1.00 79.45  ? 407 THR B CG2 1 
ATOM   2738 N  N   . LEU A 1 415 ? 203.510 178.892 95.098  1.00 78.62  ? 408 LEU B N   1 
ATOM   2739 C  CA  . LEU A 1 415 ? 203.980 178.881 93.721  1.00 82.98  ? 408 LEU B CA  1 
ATOM   2740 C  C   . LEU A 1 415 ? 205.398 178.346 93.591  1.00 92.35  ? 408 LEU B C   1 
ATOM   2741 O  O   . LEU A 1 415 ? 205.866 178.160 92.463  1.00 97.65  ? 408 LEU B O   1 
ATOM   2742 C  CB  . LEU A 1 415 ? 203.901 180.286 93.128  1.00 82.24  ? 408 LEU B CB  1 
ATOM   2743 C  CG  . LEU A 1 415 ? 202.522 180.939 93.117  1.00 82.34  ? 408 LEU B CG  1 
ATOM   2744 C  CD1 . LEU A 1 415 ? 202.649 182.429 93.334  1.00 86.00  ? 408 LEU B CD1 1 
ATOM   2745 C  CD2 . LEU A 1 415 ? 201.809 180.652 91.814  1.00 88.61  ? 408 LEU B CD2 1 
ATOM   2746 N  N   . GLN A 1 416 ? 206.086 178.103 94.708  1.00 93.31  ? 409 GLN B N   1 
ATOM   2747 C  CA  . GLN A 1 416 ? 207.457 177.589 94.712  1.00 95.38  ? 409 GLN B CA  1 
ATOM   2748 C  C   . GLN A 1 416 ? 208.406 178.526 93.969  1.00 99.96  ? 409 GLN B C   1 
ATOM   2749 O  O   . GLN A 1 416 ? 209.362 178.090 93.326  1.00 104.20 ? 409 GLN B O   1 
ATOM   2750 C  CB  . GLN A 1 416 ? 207.526 176.175 94.130  1.00 95.38  ? 409 GLN B CB  1 
ATOM   2751 C  CG  . GLN A 1 416 ? 206.552 175.196 94.756  1.00 96.85  ? 409 GLN B CG  1 
ATOM   2752 C  CD  . GLN A 1 416 ? 206.693 173.797 94.194  1.00 106.61 ? 409 GLN B CD  1 
ATOM   2753 O  OE1 . GLN A 1 416 ? 206.190 173.496 93.113  1.00 109.49 ? 409 GLN B OE1 1 
ATOM   2754 N  NE2 . GLN A 1 416 ? 207.381 172.931 94.929  1.00 108.74 ? 409 GLN B NE2 1 
ATOM   2755 N  N   . CYS A 1 417 ? 208.144 179.824 94.064  1.00 98.44  ? 410 CYS B N   1 
ATOM   2756 C  CA  . CYS A 1 417 ? 208.985 180.807 93.403  1.00 103.22 ? 410 CYS B CA  1 
ATOM   2757 C  C   . CYS A 1 417 ? 210.362 180.854 94.050  1.00 104.43 ? 410 CYS B C   1 
ATOM   2758 O  O   . CYS A 1 417 ? 210.522 180.585 95.242  1.00 103.87 ? 410 CYS B O   1 
ATOM   2759 C  CB  . CYS A 1 417 ? 208.341 182.190 93.469  1.00 106.93 ? 410 CYS B CB  1 
ATOM   2760 S  SG  . CYS A 1 417 ? 206.752 182.321 92.624  1.00 119.74 ? 410 CYS B SG  1 
ATOM   2761 N  N   . ASN A 1 418 ? 211.363 181.196 93.252  1.00 107.00 ? 411 ASN B N   1 
ATOM   2762 C  CA  . ASN A 1 418 ? 212.708 181.432 93.751  1.00 108.90 ? 411 ASN B CA  1 
ATOM   2763 C  C   . ASN A 1 418 ? 213.062 182.903 93.554  1.00 113.78 ? 411 ASN B C   1 
ATOM   2764 O  O   . ASN A 1 418 ? 212.242 183.706 93.105  1.00 115.40 ? 411 ASN B O   1 
ATOM   2765 C  CB  . ASN A 1 418 ? 213.719 180.497 93.078  1.00 110.33 ? 411 ASN B CB  1 
ATOM   2766 C  CG  . ASN A 1 418 ? 213.999 180.863 91.633  1.00 118.81 ? 411 ASN B CG  1 
ATOM   2767 O  OD1 . ASN A 1 418 ? 214.766 181.782 91.351  1.00 120.93 ? 411 ASN B OD1 1 
ATOM   2768 N  ND2 . ASN A 1 418 ? 213.389 180.132 90.708  1.00 122.50 ? 411 ASN B ND2 1 
ATOM   2769 N  N   . ALA A 1 419 ? 214.302 183.254 93.903  1.00 114.36 ? 412 ALA B N   1 
ATOM   2770 C  CA  . ALA A 1 419 ? 214.689 184.661 93.954  1.00 114.03 ? 412 ALA B CA  1 
ATOM   2771 C  C   . ALA A 1 419 ? 214.594 185.324 92.586  1.00 118.87 ? 412 ALA B C   1 
ATOM   2772 O  O   . ALA A 1 419 ? 214.146 186.471 92.476  1.00 116.73 ? 412 ALA B O   1 
ATOM   2773 C  CB  . ALA A 1 419 ? 216.104 184.792 94.513  1.00 112.83 ? 412 ALA B CB  1 
ATOM   2774 N  N   . SER A 1 420 ? 215.020 184.627 91.532  1.00 122.01 ? 413 SER B N   1 
ATOM   2775 C  CA  . SER A 1 420 ? 215.035 185.230 90.202  1.00 120.12 ? 413 SER B CA  1 
ATOM   2776 C  C   . SER A 1 420 ? 213.627 185.548 89.709  1.00 116.59 ? 413 SER B C   1 
ATOM   2777 O  O   . SER A 1 420 ? 213.390 186.624 89.149  1.00 112.27 ? 413 SER B O   1 
ATOM   2778 C  CB  . SER A 1 420 ? 215.751 184.306 89.218  1.00 117.22 ? 413 SER B CB  1 
ATOM   2779 O  OG  . SER A 1 420 ? 217.007 183.895 89.727  1.00 116.64 ? 413 SER B OG  1 
ATOM   2780 N  N   . GLY A 1 421 ? 212.687 184.637 89.907  1.00 118.43 ? 414 GLY B N   1 
ATOM   2781 C  CA  . GLY A 1 421 ? 211.352 184.844 89.390  1.00 116.04 ? 414 GLY B CA  1 
ATOM   2782 C  C   . GLY A 1 421 ? 210.406 183.748 89.820  1.00 118.19 ? 414 GLY B C   1 
ATOM   2783 O  O   . GLY A 1 421 ? 210.698 182.974 90.733  1.00 119.33 ? 414 GLY B O   1 
ATOM   2784 N  N   . CYS A 1 422 ? 209.263 183.691 89.141  1.00 119.42 ? 415 CYS B N   1 
ATOM   2785 C  CA  . CYS A 1 422 ? 208.200 182.757 89.465  1.00 120.58 ? 415 CYS B CA  1 
ATOM   2786 C  C   . CYS A 1 422 ? 207.914 181.849 88.278  1.00 122.63 ? 415 CYS B C   1 
ATOM   2787 O  O   . CYS A 1 422 ? 207.786 182.338 87.147  1.00 124.95 ? 415 CYS B O   1 
ATOM   2788 C  CB  . CYS A 1 422 ? 206.922 183.509 89.861  1.00 115.07 ? 415 CYS B CB  1 
ATOM   2789 S  SG  . CYS A 1 422 ? 206.881 184.053 91.578  1.00 120.37 ? 415 CYS B SG  1 
ATOM   2790 N  N   . PRO A 1 423 ? 207.811 180.538 88.482  1.00 118.38 ? 416 PRO B N   1 
ATOM   2791 C  CA  . PRO A 1 423 ? 207.436 179.650 87.377  1.00 115.05 ? 416 PRO B CA  1 
ATOM   2792 C  C   . PRO A 1 423 ? 206.011 179.911 86.921  1.00 113.67 ? 416 PRO B C   1 
ATOM   2793 O  O   . PRO A 1 423 ? 205.139 180.284 87.710  1.00 114.94 ? 416 PRO B O   1 
ATOM   2794 C  CB  . PRO A 1 423 ? 207.579 178.251 87.982  1.00 111.97 ? 416 PRO B CB  1 
ATOM   2795 C  CG  . PRO A 1 423 ? 207.416 178.461 89.447  1.00 108.53 ? 416 PRO B CG  1 
ATOM   2796 C  CD  . PRO A 1 423 ? 208.012 179.803 89.740  1.00 110.81 ? 416 PRO B CD  1 
ATOM   2797 N  N   . ALA A 1 424 ? 205.779 179.705 85.629  1.00 110.58 ? 417 ALA B N   1 
ATOM   2798 C  CA  . ALA A 1 424 ? 204.485 179.985 85.023  1.00 108.63 ? 417 ALA B CA  1 
ATOM   2799 C  C   . ALA A 1 424 ? 203.573 178.772 85.146  1.00 109.44 ? 417 ALA B C   1 
ATOM   2800 O  O   . ALA A 1 424 ? 203.978 177.649 84.828  1.00 110.83 ? 417 ALA B O   1 
ATOM   2801 C  CB  . ALA A 1 424 ? 204.651 180.375 83.554  1.00 107.50 ? 417 ALA B CB  1 
ATOM   2802 N  N   . GLN A 1 425 ? 202.346 179.002 85.602  1.00 109.05 ? 418 GLN B N   1 
ATOM   2803 C  CA  . GLN A 1 425 ? 201.367 177.936 85.769  1.00 109.39 ? 418 GLN B CA  1 
ATOM   2804 C  C   . GLN A 1 425 ? 199.984 178.562 85.889  1.00 109.02 ? 418 GLN B C   1 
ATOM   2805 O  O   . GLN A 1 425 ? 199.822 179.781 85.807  1.00 109.97 ? 418 GLN B O   1 
ATOM   2806 C  CB  . GLN A 1 425 ? 201.691 177.071 86.989  1.00 107.59 ? 418 GLN B CB  1 
ATOM   2807 C  CG  . GLN A 1 425 ? 201.630 177.818 88.306  1.00 104.61 ? 418 GLN B CG  1 
ATOM   2808 C  CD  . GLN A 1 425 ? 202.743 177.419 89.249  1.00 105.13 ? 418 GLN B CD  1 
ATOM   2809 O  OE1 . GLN A 1 425 ? 203.031 176.236 89.424  1.00 108.40 ? 418 GLN B OE1 1 
ATOM   2810 N  NE2 . GLN A 1 425 ? 203.383 178.408 89.858  1.00 102.98 ? 418 GLN B NE2 1 
ATOM   2811 N  N   . ASP A 1 426 ? 198.983 177.707 86.080  1.00 106.70 ? 419 ASP B N   1 
ATOM   2812 C  CA  . ASP A 1 426 ? 197.626 178.176 86.294  1.00 106.06 ? 419 ASP B CA  1 
ATOM   2813 C  C   . ASP A 1 426 ? 197.511 178.846 87.662  1.00 103.71 ? 419 ASP B C   1 
ATOM   2814 O  O   . ASP A 1 426 ? 198.312 178.578 88.561  1.00 104.41 ? 419 ASP B O   1 
ATOM   2815 C  CB  . ASP A 1 426 ? 196.641 177.015 86.198  1.00 103.35 ? 419 ASP B CB  1 
ATOM   2816 C  CG  . ASP A 1 426 ? 196.738 176.073 87.376  1.00 104.99 ? 419 ASP B CG  1 
ATOM   2817 O  OD1 . ASP A 1 426 ? 197.851 175.577 87.649  1.00 108.65 ? 419 ASP B OD1 1 
ATOM   2818 O  OD2 . ASP A 1 426 ? 195.704 175.829 88.031  1.00 103.40 ? 419 ASP B OD2 1 
ATOM   2819 N  N   . PRO A 1 427 ? 196.537 179.739 87.839  1.00 99.18  ? 420 PRO B N   1 
ATOM   2820 C  CA  . PRO A 1 427 ? 196.384 180.409 89.136  1.00 95.99  ? 420 PRO B CA  1 
ATOM   2821 C  C   . PRO A 1 427 ? 196.138 179.409 90.253  1.00 94.65  ? 420 PRO B C   1 
ATOM   2822 O  O   . PRO A 1 427 ? 195.429 178.417 90.079  1.00 95.68  ? 420 PRO B O   1 
ATOM   2823 C  CB  . PRO A 1 427 ? 195.172 181.322 88.923  1.00 92.95  ? 420 PRO B CB  1 
ATOM   2824 C  CG  . PRO A 1 427 ? 195.106 181.527 87.452  1.00 93.83  ? 420 PRO B CG  1 
ATOM   2825 C  CD  . PRO A 1 427 ? 195.585 180.250 86.840  1.00 97.71  ? 420 PRO B CD  1 
ATOM   2826 N  N   . VAL A 1 428 ? 196.733 179.681 91.409  1.00 90.23  ? 421 VAL B N   1 
ATOM   2827 C  CA  . VAL A 1 428 ? 196.592 178.804 92.563  1.00 89.35  ? 421 VAL B CA  1 
ATOM   2828 C  C   . VAL A 1 428 ? 195.281 179.106 93.273  1.00 89.87  ? 421 VAL B C   1 
ATOM   2829 O  O   . VAL A 1 428 ? 194.925 180.269 93.497  1.00 89.11  ? 421 VAL B O   1 
ATOM   2830 C  CB  . VAL A 1 428 ? 197.795 178.956 93.508  1.00 85.18  ? 421 VAL B CB  1 
ATOM   2831 C  CG1 . VAL A 1 428 ? 199.041 178.430 92.837  1.00 86.60  ? 421 VAL B CG1 1 
ATOM   2832 C  CG2 . VAL A 1 428 ? 197.985 180.404 93.899  1.00 81.73  ? 421 VAL B CG2 1 
ATOM   2833 N  N   . LYS A 1 429 ? 194.549 178.057 93.610  1.00 86.99  ? 422 LYS B N   1 
ATOM   2834 C  CA  . LYS A 1 429 ? 193.268 178.233 94.267  1.00 84.31  ? 422 LYS B CA  1 
ATOM   2835 C  C   . LYS A 1 429 ? 193.472 178.598 95.735  1.00 82.16  ? 422 LYS B C   1 
ATOM   2836 O  O   . LYS A 1 429 ? 194.505 178.271 96.323  1.00 82.12  ? 422 LYS B O   1 
ATOM   2837 C  CB  . LYS A 1 429 ? 192.437 176.962 94.158  1.00 88.65  ? 422 LYS B CB  1 
ATOM   2838 C  CG  . LYS A 1 429 ? 191.480 176.948 92.979  1.00 92.72  ? 422 LYS B CG  1 
ATOM   2839 C  CD  . LYS A 1 429 ? 192.230 176.812 91.668  1.00 93.38  ? 422 LYS B CD  1 
ATOM   2840 C  CE  . LYS A 1 429 ? 192.632 175.367 91.428  1.00 95.72  ? 422 LYS B CE  1 
ATOM   2841 N  NZ  . LYS A 1 429 ? 193.609 175.232 90.316  1.00 93.13  ? 422 LYS B NZ  1 
ATOM   2842 N  N   . PRO A 1 430 ? 192.507 179.291 96.343  1.00 81.33  ? 423 PRO B N   1 
ATOM   2843 C  CA  . PRO A 1 430 ? 192.673 179.685 97.750  1.00 79.20  ? 423 PRO B CA  1 
ATOM   2844 C  C   . PRO A 1 430 ? 192.890 178.519 98.696  1.00 79.17  ? 423 PRO B C   1 
ATOM   2845 O  O   . PRO A 1 430 ? 193.682 178.638 99.637  1.00 79.74  ? 423 PRO B O   1 
ATOM   2846 C  CB  . PRO A 1 430 ? 191.365 180.424 98.054  1.00 75.87  ? 423 PRO B CB  1 
ATOM   2847 C  CG  . PRO A 1 430 ? 190.914 180.930 96.745  1.00 75.27  ? 423 PRO B CG  1 
ATOM   2848 C  CD  . PRO A 1 430 ? 191.298 179.883 95.750  1.00 80.27  ? 423 PRO B CD  1 
ATOM   2849 N  N   . TRP A 1 431 ? 192.220 177.388 98.479  1.00 80.99  ? 424 TRP B N   1 
ATOM   2850 C  CA  . TRP A 1 431 ? 192.391 176.267 99.393  1.00 83.53  ? 424 TRP B CA  1 
ATOM   2851 C  C   . TRP A 1 431 ? 193.769 175.632 99.284  1.00 86.41  ? 424 TRP B C   1 
ATOM   2852 O  O   . TRP A 1 431 ? 194.189 174.936 100.212 1.00 87.50  ? 424 TRP B O   1 
ATOM   2853 C  CB  . TRP A 1 431 ? 191.309 175.214 99.156  1.00 82.66  ? 424 TRP B CB  1 
ATOM   2854 C  CG  . TRP A 1 431 ? 191.249 174.702 97.764  1.00 86.71  ? 424 TRP B CG  1 
ATOM   2855 C  CD1 . TRP A 1 431 ? 190.461 175.165 96.757  1.00 88.66  ? 424 TRP B CD1 1 
ATOM   2856 C  CD2 . TRP A 1 431 ? 192.000 173.613 97.219  1.00 92.85  ? 424 TRP B CD2 1 
ATOM   2857 N  NE1 . TRP A 1 431 ? 190.676 174.437 95.615  1.00 94.08  ? 424 TRP B NE1 1 
ATOM   2858 C  CE2 . TRP A 1 431 ? 191.617 173.476 95.872  1.00 96.47  ? 424 TRP B CE2 1 
ATOM   2859 C  CE3 . TRP A 1 431 ? 192.960 172.741 97.739  1.00 91.02  ? 424 TRP B CE3 1 
ATOM   2860 C  CZ2 . TRP A 1 431 ? 192.161 172.505 95.038  1.00 95.62  ? 424 TRP B CZ2 1 
ATOM   2861 C  CZ3 . TRP A 1 431 ? 193.498 171.777 96.910  1.00 91.02  ? 424 TRP B CZ3 1 
ATOM   2862 C  CH2 . TRP A 1 431 ? 193.098 171.667 95.574  1.00 96.16  ? 424 TRP B CH2 1 
ATOM   2863 N  N   . GLN A 1 432 ? 194.485 175.856 98.181  1.00 86.89  ? 425 GLN B N   1 
ATOM   2864 C  CA  . GLN A 1 432 ? 195.840 175.332 98.060  1.00 85.99  ? 425 GLN B CA  1 
ATOM   2865 C  C   . GLN A 1 432 ? 196.821 176.055 98.966  1.00 82.08  ? 425 GLN B C   1 
ATOM   2866 O  O   . GLN A 1 432 ? 197.925 175.552 99.190  1.00 85.03  ? 425 GLN B O   1 
ATOM   2867 C  CB  . GLN A 1 432 ? 196.318 175.421 96.614  1.00 85.32  ? 425 GLN B CB  1 
ATOM   2868 C  CG  . GLN A 1 432 ? 195.570 174.522 95.665  1.00 89.12  ? 425 GLN B CG  1 
ATOM   2869 C  CD  . GLN A 1 432 ? 196.280 174.374 94.346  1.00 95.65  ? 425 GLN B CD  1 
ATOM   2870 O  OE1 . GLN A 1 432 ? 197.506 174.437 94.280  1.00 97.94  ? 425 GLN B OE1 1 
ATOM   2871 N  NE2 . GLN A 1 432 ? 195.516 174.174 93.282  1.00 98.37  ? 425 GLN B NE2 1 
ATOM   2872 N  N   . LEU A 1 433 ? 196.453 177.227 99.481  1.00 75.89  ? 426 LEU B N   1 
ATOM   2873 C  CA  . LEU A 1 433 ? 197.330 177.927 100.408 1.00 75.88  ? 426 LEU B CA  1 
ATOM   2874 C  C   . LEU A 1 433 ? 197.363 177.248 101.769 1.00 79.65  ? 426 LEU B C   1 
ATOM   2875 O  O   . LEU A 1 433 ? 198.372 177.331 102.476 1.00 83.14  ? 426 LEU B O   1 
ATOM   2876 C  CB  . LEU A 1 433 ? 196.878 179.377 100.565 1.00 74.02  ? 426 LEU B CB  1 
ATOM   2877 C  CG  . LEU A 1 433 ? 197.442 180.414 99.601  1.00 71.11  ? 426 LEU B CG  1 
ATOM   2878 C  CD1 . LEU A 1 433 ? 197.050 181.794 100.066 1.00 70.55  ? 426 LEU B CD1 1 
ATOM   2879 C  CD2 . LEU A 1 433 ? 198.944 180.292 99.513  1.00 74.32  ? 426 LEU B CD2 1 
ATOM   2880 N  N   . LEU A 1 434 ? 196.277 176.573 102.149 1.00 78.15  ? 427 LEU B N   1 
ATOM   2881 C  CA  . LEU A 1 434 ? 196.153 176.074 103.514 1.00 78.82  ? 427 LEU B CA  1 
ATOM   2882 C  C   . LEU A 1 434 ? 197.228 175.052 103.854 1.00 81.02  ? 427 LEU B C   1 
ATOM   2883 O  O   . LEU A 1 434 ? 197.632 174.946 105.015 1.00 81.97  ? 427 LEU B O   1 
ATOM   2884 C  CB  . LEU A 1 434 ? 194.768 175.474 103.723 1.00 79.44  ? 427 LEU B CB  1 
ATOM   2885 C  CG  . LEU A 1 434 ? 193.657 176.506 103.856 1.00 77.27  ? 427 LEU B CG  1 
ATOM   2886 C  CD1 . LEU A 1 434 ? 192.360 175.833 104.244 1.00 79.88  ? 427 LEU B CD1 1 
ATOM   2887 C  CD2 . LEU A 1 434 ? 194.047 177.550 104.875 1.00 75.14  ? 427 LEU B CD2 1 
ATOM   2888 N  N   . GLU A 1 435 ? 197.697 174.286 102.869 1.00 81.96  ? 428 GLU B N   1 
ATOM   2889 C  CA  . GLU A 1 435 ? 198.765 173.332 103.142 1.00 81.60  ? 428 GLU B CA  1 
ATOM   2890 C  C   . GLU A 1 435 ? 200.032 174.047 103.586 1.00 80.65  ? 428 GLU B C   1 
ATOM   2891 O  O   . GLU A 1 435 ? 200.708 173.606 104.522 1.00 81.68  ? 428 GLU B O   1 
ATOM   2892 C  CB  . GLU A 1 435 ? 199.041 172.478 101.906 1.00 84.15  ? 428 GLU B CB  1 
ATOM   2893 C  CG  . GLU A 1 435 ? 197.797 171.937 101.233 1.00 91.14  ? 428 GLU B CG  1 
ATOM   2894 C  CD  . GLU A 1 435 ? 197.876 172.019 99.723  1.00 99.68  ? 428 GLU B CD  1 
ATOM   2895 O  OE1 . GLU A 1 435 ? 198.951 172.385 99.205  1.00 100.30 ? 428 GLU B OE1 1 
ATOM   2896 O  OE2 . GLU A 1 435 ? 196.866 171.719 99.054  1.00 99.97  ? 428 GLU B OE2 1 
ATOM   2897 N  N   . ASN A 1 436 ? 200.364 175.157 102.935 1.00 76.14  ? 429 ASN B N   1 
ATOM   2898 C  CA  . ASN A 1 436 ? 201.578 175.902 103.228 1.00 73.66  ? 429 ASN B CA  1 
ATOM   2899 C  C   . ASN A 1 436 ? 201.354 177.050 104.198 1.00 75.70  ? 429 ASN B C   1 
ATOM   2900 O  O   . ASN A 1 436 ? 202.289 177.814 104.449 1.00 78.03  ? 429 ASN B O   1 
ATOM   2901 C  CB  . ASN A 1 436 ? 202.189 176.436 101.935 1.00 75.96  ? 429 ASN B CB  1 
ATOM   2902 C  CG  . ASN A 1 436 ? 202.599 175.330 100.991 1.00 82.88  ? 429 ASN B CG  1 
ATOM   2903 O  OD1 . ASN A 1 436 ? 201.840 174.943 100.104 1.00 85.40  ? 429 ASN B OD1 1 
ATOM   2904 N  ND2 . ASN A 1 436 ? 203.806 174.812 101.176 1.00 83.04  ? 429 ASN B ND2 1 
ATOM   2905 N  N   . MET A 1 437 ? 200.144 177.201 104.733 1.00 76.59  ? 430 MET B N   1 
ATOM   2906 C  CA  . MET A 1 437 ? 199.881 178.211 105.750 1.00 75.74  ? 430 MET B CA  1 
ATOM   2907 C  C   . MET A 1 437 ? 200.071 177.666 107.157 1.00 78.12  ? 430 MET B C   1 
ATOM   2908 O  O   . MET A 1 437 ? 200.669 178.335 108.003 1.00 81.99  ? 430 MET B O   1 
ATOM   2909 C  CB  . MET A 1 437 ? 198.467 178.767 105.594 1.00 73.68  ? 430 MET B CB  1 
ATOM   2910 C  CG  . MET A 1 437 ? 198.348 179.829 104.529 1.00 74.70  ? 430 MET B CG  1 
ATOM   2911 S  SD  . MET A 1 437 ? 198.496 181.484 105.204 1.00 94.99  ? 430 MET B SD  1 
ATOM   2912 C  CE  . MET A 1 437 ? 196.801 182.026 105.081 1.00 82.22  ? 430 MET B CE  1 
ATOM   2913 N  N   . TYR A 1 438 ? 199.572 176.466 107.429 1.00 76.75  ? 431 TYR B N   1 
ATOM   2914 C  CA  . TYR A 1 438 ? 199.949 175.781 108.654 1.00 75.93  ? 431 TYR B CA  1 
ATOM   2915 C  C   . TYR A 1 438 ? 201.441 175.489 108.623 1.00 79.69  ? 431 TYR B C   1 
ATOM   2916 O  O   . TYR A 1 438 ? 202.005 175.199 107.566 1.00 82.70  ? 431 TYR B O   1 
ATOM   2917 C  CB  . TYR A 1 438 ? 199.170 174.476 108.798 1.00 78.81  ? 431 TYR B CB  1 
ATOM   2918 C  CG  . TYR A 1 438 ? 197.705 174.650 109.096 1.00 82.04  ? 431 TYR B CG  1 
ATOM   2919 C  CD1 . TYR A 1 438 ? 197.285 175.267 110.260 1.00 85.93  ? 431 TYR B CD1 1 
ATOM   2920 C  CD2 . TYR A 1 438 ? 196.742 174.178 108.223 1.00 81.10  ? 431 TYR B CD2 1 
ATOM   2921 C  CE1 . TYR A 1 438 ? 195.949 175.423 110.539 1.00 85.10  ? 431 TYR B CE1 1 
ATOM   2922 C  CE2 . TYR A 1 438 ? 195.404 174.330 108.494 1.00 82.02  ? 431 TYR B CE2 1 
ATOM   2923 C  CZ  . TYR A 1 438 ? 195.013 174.954 109.653 1.00 82.60  ? 431 TYR B CZ  1 
ATOM   2924 O  OH  . TYR A 1 438 ? 193.677 175.108 109.933 1.00 81.11  ? 431 TYR B OH  1 
ATOM   2925 N  N   . ASN A 1 439 ? 202.082 175.569 109.787 1.00 82.09  ? 432 ASN B N   1 
ATOM   2926 C  CA  . ASN A 1 439 ? 203.505 175.250 109.910 1.00 90.10  ? 432 ASN B CA  1 
ATOM   2927 C  C   . ASN A 1 439 ? 204.354 176.142 109.008 1.00 86.92  ? 432 ASN B C   1 
ATOM   2928 O  O   . ASN A 1 439 ? 205.329 175.694 108.404 1.00 94.44  ? 432 ASN B O   1 
ATOM   2929 C  CB  . ASN A 1 439 ? 203.757 173.775 109.598 1.00 97.40  ? 432 ASN B CB  1 
ATOM   2930 C  CG  . ASN A 1 439 ? 204.884 173.187 110.410 1.00 108.54 ? 432 ASN B CG  1 
ATOM   2931 O  OD1 . ASN A 1 439 ? 205.204 173.667 111.496 1.00 109.07 ? 432 ASN B OD1 1 
ATOM   2932 N  ND2 . ASN A 1 439 ? 205.497 172.133 109.879 1.00 117.16 ? 432 ASN B ND2 1 
ATOM   2933 N  N   . LEU A 1 440 ? 203.982 177.413 108.914 1.00 78.02  ? 433 LEU B N   1 
ATOM   2934 C  CA  . LEU A 1 440 ? 204.654 178.369 108.046 1.00 73.33  ? 433 LEU B CA  1 
ATOM   2935 C  C   . LEU A 1 440 ? 205.480 179.333 108.882 1.00 77.38  ? 433 LEU B C   1 
ATOM   2936 O  O   . LEU A 1 440 ? 204.998 179.852 109.891 1.00 81.31  ? 433 LEU B O   1 
ATOM   2937 C  CB  . LEU A 1 440 ? 203.645 179.147 107.205 1.00 72.29  ? 433 LEU B CB  1 
ATOM   2938 C  CG  . LEU A 1 440 ? 204.111 180.510 106.701 1.00 70.96  ? 433 LEU B CG  1 
ATOM   2939 C  CD1 . LEU A 1 440 ? 205.149 180.344 105.612 1.00 71.07  ? 433 LEU B CD1 1 
ATOM   2940 C  CD2 . LEU A 1 440 ? 202.933 181.309 106.194 1.00 71.77  ? 433 LEU B CD2 1 
ATOM   2941 N  N   . THR A 1 441 ? 206.719 179.569 108.460 1.00 82.12  ? 434 THR B N   1 
ATOM   2942 C  CA  . THR A 1 441 ? 207.595 180.551 109.084 1.00 80.32  ? 434 THR B CA  1 
ATOM   2943 C  C   . THR A 1 441 ? 207.798 181.706 108.114 1.00 76.45  ? 434 THR B C   1 
ATOM   2944 O  O   . THR A 1 441 ? 208.286 181.502 106.997 1.00 74.67  ? 434 THR B O   1 
ATOM   2945 C  CB  . THR A 1 441 ? 208.938 179.928 109.464 1.00 79.32  ? 434 THR B CB  1 
ATOM   2946 O  OG1 . THR A 1 441 ? 208.761 179.068 110.595 1.00 79.93  ? 434 THR B OG1 1 
ATOM   2947 C  CG2 . THR A 1 441 ? 209.945 181.009 109.813 1.00 74.00  ? 434 THR B CG2 1 
ATOM   2948 N  N   . PHE A 1 442 ? 207.424 182.910 108.536 1.00 74.55  ? 435 PHE B N   1 
ATOM   2949 C  CA  . PHE A 1 442 ? 207.564 184.100 107.713 1.00 74.39  ? 435 PHE B CA  1 
ATOM   2950 C  C   . PHE A 1 442 ? 208.245 185.196 108.513 1.00 79.15  ? 435 PHE B C   1 
ATOM   2951 O  O   . PHE A 1 442 ? 207.937 185.397 109.690 1.00 82.05  ? 435 PHE B O   1 
ATOM   2952 C  CB  . PHE A 1 442 ? 206.211 184.597 107.201 1.00 70.37  ? 435 PHE B CB  1 
ATOM   2953 C  CG  . PHE A 1 442 ? 205.196 184.824 108.280 1.00 66.95  ? 435 PHE B CG  1 
ATOM   2954 C  CD1 . PHE A 1 442 ? 204.400 183.791 108.730 1.00 73.37  ? 435 PHE B CD1 1 
ATOM   2955 C  CD2 . PHE A 1 442 ? 205.030 186.073 108.835 1.00 66.62  ? 435 PHE B CD2 1 
ATOM   2956 C  CE1 . PHE A 1 442 ? 203.464 184.002 109.720 1.00 74.53  ? 435 PHE B CE1 1 
ATOM   2957 C  CE2 . PHE A 1 442 ? 204.096 186.287 109.825 1.00 70.54  ? 435 PHE B CE2 1 
ATOM   2958 C  CZ  . PHE A 1 442 ? 203.313 185.250 110.267 1.00 71.08  ? 435 PHE B CZ  1 
ATOM   2959 N  N   . HIS A 1 443 ? 209.164 185.907 107.869 1.00 79.74  ? 436 HIS B N   1 
ATOM   2960 C  CA  . HIS A 1 443 ? 209.910 186.977 108.514 1.00 78.81  ? 436 HIS B CA  1 
ATOM   2961 C  C   . HIS A 1 443 ? 209.161 188.288 108.324 1.00 77.89  ? 436 HIS B C   1 
ATOM   2962 O  O   . HIS A 1 443 ? 208.874 188.684 107.191 1.00 77.98  ? 436 HIS B O   1 
ATOM   2963 C  CB  . HIS A 1 443 ? 211.318 187.084 107.934 1.00 82.62  ? 436 HIS B CB  1 
ATOM   2964 C  CG  . HIS A 1 443 ? 212.101 185.812 108.006 1.00 87.13  ? 436 HIS B CG  1 
ATOM   2965 N  ND1 . HIS A 1 443 ? 211.851 184.737 107.181 1.00 90.32  ? 436 HIS B ND1 1 
ATOM   2966 C  CD2 . HIS A 1 443 ? 213.136 185.446 108.797 1.00 90.41  ? 436 HIS B CD2 1 
ATOM   2967 C  CE1 . HIS A 1 443 ? 212.695 183.762 107.464 1.00 92.81  ? 436 HIS B CE1 1 
ATOM   2968 N  NE2 . HIS A 1 443 ? 213.486 184.166 108.442 1.00 95.10  ? 436 HIS B NE2 1 
ATOM   2969 N  N   . VAL A 1 444 ? 208.850 188.959 109.426 1.00 79.70  ? 437 VAL B N   1 
ATOM   2970 C  CA  . VAL A 1 444 ? 208.165 190.244 109.400 1.00 77.07  ? 437 VAL B CA  1 
ATOM   2971 C  C   . VAL A 1 444 ? 209.077 191.256 110.073 1.00 83.84  ? 437 VAL B C   1 
ATOM   2972 O  O   . VAL A 1 444 ? 209.343 191.157 111.277 1.00 89.06  ? 437 VAL B O   1 
ATOM   2973 C  CB  . VAL A 1 444 ? 206.803 190.182 110.099 1.00 71.61  ? 437 VAL B CB  1 
ATOM   2974 C  CG1 . VAL A 1 444 ? 206.308 191.572 110.405 1.00 67.11  ? 437 VAL B CG1 1 
ATOM   2975 C  CG2 . VAL A 1 444 ? 205.810 189.444 109.238 1.00 71.50  ? 437 VAL B CG2 1 
ATOM   2976 N  N   . GLY A 1 445 ? 209.556 192.229 109.303 1.00 81.05  ? 438 GLY B N   1 
ATOM   2977 C  CA  . GLY A 1 445 ? 210.457 193.231 109.845 1.00 83.12  ? 438 GLY B CA  1 
ATOM   2978 C  C   . GLY A 1 445 ? 211.740 192.667 110.411 1.00 89.81  ? 438 GLY B C   1 
ATOM   2979 O  O   . GLY A 1 445 ? 212.354 193.292 111.281 1.00 89.42  ? 438 GLY B O   1 
ATOM   2980 N  N   . GLY A 1 446 ? 212.167 191.499 109.937 1.00 90.98  ? 439 GLY B N   1 
ATOM   2981 C  CA  . GLY A 1 446 ? 213.352 190.846 110.448 1.00 90.00  ? 439 GLY B CA  1 
ATOM   2982 C  C   . GLY A 1 446 ? 213.131 189.947 111.645 1.00 91.35  ? 439 GLY B C   1 
ATOM   2983 O  O   . GLY A 1 446 ? 214.087 189.312 112.105 1.00 92.33  ? 439 GLY B O   1 
ATOM   2984 N  N   . LEU A 1 447 ? 211.908 189.870 112.164 1.00 90.64  ? 440 LEU B N   1 
ATOM   2985 C  CA  . LEU A 1 447 ? 211.596 189.032 113.312 1.00 86.57  ? 440 LEU B CA  1 
ATOM   2986 C  C   . LEU A 1 447 ? 210.797 187.824 112.855 1.00 87.44  ? 440 LEU B C   1 
ATOM   2987 O  O   . LEU A 1 447 ? 209.687 187.992 112.330 1.00 86.29  ? 440 LEU B O   1 
ATOM   2988 C  CB  . LEU A 1 447 ? 210.813 189.822 114.356 1.00 83.61  ? 440 LEU B CB  1 
ATOM   2989 C  CG  . LEU A 1 447 ? 211.208 191.289 114.514 1.00 85.00  ? 440 LEU B CG  1 
ATOM   2990 C  CD1 . LEU A 1 447 ? 210.212 192.003 115.407 1.00 82.80  ? 440 LEU B CD1 1 
ATOM   2991 C  CD2 . LEU A 1 447 ? 212.619 191.413 115.068 1.00 79.56  ? 440 LEU B CD2 1 
ATOM   2992 N  N   . PRO A 1 448 ? 211.304 186.606 113.022 1.00 90.71  ? 441 PRO B N   1 
ATOM   2993 C  CA  . PRO A 1 448 ? 210.567 185.432 112.548 1.00 86.37  ? 441 PRO B CA  1 
ATOM   2994 C  C   . PRO A 1 448 ? 209.273 185.220 113.315 1.00 80.22  ? 441 PRO B C   1 
ATOM   2995 O  O   . PRO A 1 448 ? 209.168 185.518 114.506 1.00 80.00  ? 441 PRO B O   1 
ATOM   2996 C  CB  . PRO A 1 448 ? 211.545 184.278 112.789 1.00 88.35  ? 441 PRO B CB  1 
ATOM   2997 C  CG  . PRO A 1 448 ? 212.424 184.758 113.887 1.00 90.88  ? 441 PRO B CG  1 
ATOM   2998 C  CD  . PRO A 1 448 ? 212.565 186.239 113.687 1.00 91.67  ? 441 PRO B CD  1 
ATOM   2999 N  N   . LEU A 1 449 ? 208.280 184.696 112.604 1.00 81.44  ? 442 LEU B N   1 
ATOM   3000 C  CA  . LEU A 1 449 ? 207.002 184.317 113.183 1.00 80.60  ? 442 LEU B CA  1 
ATOM   3001 C  C   . LEU A 1 449 ? 206.579 182.985 112.587 1.00 79.72  ? 442 LEU B C   1 
ATOM   3002 O  O   . LEU A 1 449 ? 206.947 182.651 111.459 1.00 78.57  ? 442 LEU B O   1 
ATOM   3003 C  CB  . LEU A 1 449 ? 205.920 185.371 112.927 1.00 78.39  ? 442 LEU B CB  1 
ATOM   3004 C  CG  . LEU A 1 449 ? 205.926 186.601 113.831 1.00 79.22  ? 442 LEU B CG  1 
ATOM   3005 C  CD1 . LEU A 1 449 ? 204.698 187.453 113.571 1.00 76.21  ? 442 LEU B CD1 1 
ATOM   3006 C  CD2 . LEU A 1 449 ? 205.997 186.191 115.289 1.00 82.45  ? 442 LEU B CD2 1 
ATOM   3007 N  N   . ARG A 1 450 ? 205.808 182.222 113.351 1.00 78.14  ? 443 ARG B N   1 
ATOM   3008 C  CA  . ARG A 1 450 ? 205.356 180.911 112.915 1.00 77.42  ? 443 ARG B CA  1 
ATOM   3009 C  C   . ARG A 1 450 ? 203.882 180.742 113.234 1.00 77.77  ? 443 ARG B C   1 
ATOM   3010 O  O   . ARG A 1 450 ? 203.397 181.241 114.252 1.00 82.76  ? 443 ARG B O   1 
ATOM   3011 C  CB  . ARG A 1 450 ? 206.163 179.795 113.582 1.00 81.29  ? 443 ARG B CB  1 
ATOM   3012 C  CG  . ARG A 1 450 ? 205.997 178.436 112.927 1.00 88.20  ? 443 ARG B CG  1 
ATOM   3013 C  CD  . ARG A 1 450 ? 206.955 177.416 113.514 1.00 90.79  ? 443 ARG B CD  1 
ATOM   3014 N  NE  . ARG A 1 450 ? 206.384 176.075 113.517 1.00 93.22  ? 443 ARG B NE  1 
ATOM   3015 C  CZ  . ARG A 1 450 ? 205.491 175.645 114.397 1.00 95.89  ? 443 ARG B CZ  1 
ATOM   3016 N  NH1 . ARG A 1 450 ? 205.041 176.426 115.365 1.00 92.60  ? 443 ARG B NH1 1 
ATOM   3017 N  NH2 . ARG A 1 450 ? 205.038 174.398 114.305 1.00 99.68  ? 443 ARG B NH2 1 
ATOM   3018 N  N   . PHE A 1 451 ? 203.175 180.039 112.359 1.00 80.17  ? 444 PHE B N   1 
ATOM   3019 C  CA  . PHE A 1 451 ? 201.775 179.708 112.568 1.00 83.09  ? 444 PHE B CA  1 
ATOM   3020 C  C   . PHE A 1 451 ? 201.681 178.319 113.182 1.00 85.87  ? 444 PHE B C   1 
ATOM   3021 O  O   . PHE A 1 451 ? 202.244 177.361 112.645 1.00 88.53  ? 444 PHE B O   1 
ATOM   3022 C  CB  . PHE A 1 451 ? 200.998 179.753 111.253 1.00 83.86  ? 444 PHE B CB  1 
ATOM   3023 C  CG  . PHE A 1 451 ? 200.522 181.125 110.870 1.00 80.56  ? 444 PHE B CG  1 
ATOM   3024 C  CD1 . PHE A 1 451 ? 200.366 182.111 111.820 1.00 79.30  ? 444 PHE B CD1 1 
ATOM   3025 C  CD2 . PHE A 1 451 ? 200.215 181.420 109.556 1.00 77.17  ? 444 PHE B CD2 1 
ATOM   3026 C  CE1 . PHE A 1 451 ? 199.926 183.366 111.465 1.00 76.86  ? 444 PHE B CE1 1 
ATOM   3027 C  CE2 . PHE A 1 451 ? 199.771 182.672 109.199 1.00 73.94  ? 444 PHE B CE2 1 
ATOM   3028 C  CZ  . PHE A 1 451 ? 199.627 183.644 110.154 1.00 74.52  ? 444 PHE B CZ  1 
ATOM   3029 N  N   . ASP A 1 452 ? 200.968 178.212 114.298 1.00 87.43  ? 445 ASP B N   1 
ATOM   3030 C  CA  . ASP A 1 452 ? 200.825 176.932 114.969 1.00 89.09  ? 445 ASP B CA  1 
ATOM   3031 C  C   . ASP A 1 452 ? 200.004 175.972 114.116 1.00 89.12  ? 445 ASP B C   1 
ATOM   3032 O  O   . ASP A 1 452 ? 199.338 176.360 113.155 1.00 89.67  ? 445 ASP B O   1 
ATOM   3033 C  CB  . ASP A 1 452 ? 200.160 177.111 116.332 1.00 90.39  ? 445 ASP B CB  1 
ATOM   3034 C  CG  . ASP A 1 452 ? 201.144 177.022 117.474 1.00 99.79  ? 445 ASP B CG  1 
ATOM   3035 O  OD1 . ASP A 1 452 ? 202.299 176.616 117.230 1.00 105.52 ? 445 ASP B OD1 1 
ATOM   3036 O  OD2 . ASP A 1 452 ? 200.762 177.354 118.615 1.00 99.32  ? 445 ASP B OD2 1 
ATOM   3037 N  N   . SER A 1 453 ? 200.065 174.690 114.479 1.00 89.97  ? 446 SER B N   1 
ATOM   3038 C  CA  . SER A 1 453 ? 199.226 173.705 113.809 1.00 92.20  ? 446 SER B CA  1 
ATOM   3039 C  C   . SER A 1 453 ? 197.751 173.991 114.041 1.00 91.88  ? 446 SER B C   1 
ATOM   3040 O  O   . SER A 1 453 ? 196.905 173.584 113.238 1.00 90.96  ? 446 SER B O   1 
ATOM   3041 C  CB  . SER A 1 453 ? 199.577 172.297 114.285 1.00 89.80  ? 446 SER B CB  1 
ATOM   3042 O  OG  . SER A 1 453 ? 199.166 171.328 113.338 1.00 86.28  ? 446 SER B OG  1 
ATOM   3043 N  N   . SER A 1 454 ? 197.423 174.682 115.127 1.00 93.76  ? 447 SER B N   1 
ATOM   3044 C  CA  . SER A 1 454 ? 196.062 175.127 115.386 1.00 93.76  ? 447 SER B CA  1 
ATOM   3045 C  C   . SER A 1 454 ? 195.795 176.528 114.855 1.00 89.19  ? 447 SER B C   1 
ATOM   3046 O  O   . SER A 1 454 ? 194.682 177.036 115.022 1.00 88.86  ? 447 SER B O   1 
ATOM   3047 C  CB  . SER A 1 454 ? 195.764 175.075 116.886 1.00 97.12  ? 447 SER B CB  1 
ATOM   3048 O  OG  . SER A 1 454 ? 196.244 176.235 117.538 1.00 96.45  ? 447 SER B OG  1 
ATOM   3049 N  N   . GLY A 1 455 ? 196.783 177.164 114.233 1.00 84.47  ? 448 GLY B N   1 
ATOM   3050 C  CA  . GLY A 1 455 ? 196.548 178.393 113.506 1.00 83.12  ? 448 GLY B CA  1 
ATOM   3051 C  C   . GLY A 1 455 ? 196.681 179.681 114.281 1.00 84.18  ? 448 GLY B C   1 
ATOM   3052 O  O   . GLY A 1 455 ? 196.079 180.686 113.891 1.00 81.28  ? 448 GLY B O   1 
ATOM   3053 N  N   . ASN A 1 456 ? 197.451 179.698 115.362 1.00 88.41  ? 449 ASN B N   1 
ATOM   3054 C  CA  . ASN A 1 456 ? 197.678 180.920 116.119 1.00 87.29  ? 449 ASN B CA  1 
ATOM   3055 C  C   . ASN A 1 456 ? 199.167 181.208 116.175 1.00 88.37  ? 449 ASN B C   1 
ATOM   3056 O  O   . ASN A 1 456 ? 199.977 180.297 116.361 1.00 92.33  ? 449 ASN B O   1 
ATOM   3057 C  CB  . ASN A 1 456 ? 197.128 180.820 117.540 1.00 85.61  ? 449 ASN B CB  1 
ATOM   3058 C  CG  . ASN A 1 456 ? 195.917 179.926 117.630 1.00 88.65  ? 449 ASN B CG  1 
ATOM   3059 O  OD1 . ASN A 1 456 ? 194.902 180.169 116.981 1.00 89.67  ? 449 ASN B OD1 1 
ATOM   3060 N  ND2 . ASN A 1 456 ? 196.011 178.890 118.450 1.00 89.97  ? 449 ASN B ND2 1 
ATOM   3061 N  N   . VAL A 1 457 ? 199.526 182.478 116.016 1.00 82.16  ? 450 VAL B N   1 
ATOM   3062 C  CA  . VAL A 1 457 ? 200.923 182.854 116.140 1.00 84.55  ? 450 VAL B CA  1 
ATOM   3063 C  C   . VAL A 1 457 ? 201.345 182.724 117.597 1.00 90.31  ? 450 VAL B C   1 
ATOM   3064 O  O   . VAL A 1 457 ? 200.520 182.786 118.518 1.00 93.04  ? 450 VAL B O   1 
ATOM   3065 C  CB  . VAL A 1 457 ? 201.157 184.280 115.614 1.00 82.93  ? 450 VAL B CB  1 
ATOM   3066 C  CG1 . VAL A 1 457 ? 200.876 185.297 116.698 1.00 80.69  ? 450 VAL B CG1 1 
ATOM   3067 C  CG2 . VAL A 1 457 ? 202.575 184.424 115.100 1.00 85.71  ? 450 VAL B CG2 1 
ATOM   3068 N  N   . ASP A 1 458 ? 202.638 182.516 117.810 1.00 90.93  ? 451 ASP B N   1 
ATOM   3069 C  CA  . ASP A 1 458 ? 203.202 182.384 119.144 1.00 90.26  ? 451 ASP B CA  1 
ATOM   3070 C  C   . ASP A 1 458 ? 204.132 183.557 119.412 1.00 90.64  ? 451 ASP B C   1 
ATOM   3071 O  O   . ASP A 1 458 ? 205.034 183.837 118.617 1.00 91.23  ? 451 ASP B O   1 
ATOM   3072 C  CB  . ASP A 1 458 ? 203.945 181.053 119.311 1.00 91.55  ? 451 ASP B CB  1 
ATOM   3073 C  CG  . ASP A 1 458 ? 205.082 180.869 118.311 1.00 98.07  ? 451 ASP B CG  1 
ATOM   3074 O  OD1 . ASP A 1 458 ? 205.063 181.494 117.232 1.00 100.55 ? 451 ASP B OD1 1 
ATOM   3075 O  OD2 . ASP A 1 458 ? 206.007 180.085 118.611 1.00 98.06  ? 451 ASP B OD2 1 
ATOM   3076 N  N   . MET A 1 459 ? 203.901 184.249 120.523 1.00 90.06  ? 452 MET B N   1 
ATOM   3077 C  CA  . MET A 1 459 ? 204.737 185.382 120.881 1.00 91.43  ? 452 MET B CA  1 
ATOM   3078 C  C   . MET A 1 459 ? 204.794 185.507 122.394 1.00 88.72  ? 452 MET B C   1 
ATOM   3079 O  O   . MET A 1 459 ? 203.897 185.060 123.112 1.00 87.04  ? 452 MET B O   1 
ATOM   3080 C  CB  . MET A 1 459 ? 204.228 186.679 120.245 1.00 90.35  ? 452 MET B CB  1 
ATOM   3081 C  CG  . MET A 1 459 ? 202.886 187.146 120.756 1.00 86.80  ? 452 MET B CG  1 
ATOM   3082 S  SD  . MET A 1 459 ? 202.397 188.693 119.976 1.00 96.61  ? 452 MET B SD  1 
ATOM   3083 C  CE  . MET A 1 459 ? 203.038 188.468 118.320 1.00 85.84  ? 452 MET B CE  1 
ATOM   3084 N  N   . GLU A 1 460 ? 205.866 186.131 122.867 1.00 87.92  ? 453 GLU B N   1 
ATOM   3085 C  CA  . GLU A 1 460 ? 206.121 186.243 124.289 1.00 86.65  ? 453 GLU B CA  1 
ATOM   3086 C  C   . GLU A 1 460 ? 205.173 187.250 124.927 1.00 85.79  ? 453 GLU B C   1 
ATOM   3087 O  O   . GLU A 1 460 ? 204.417 187.954 124.257 1.00 91.33  ? 453 GLU B O   1 
ATOM   3088 C  CB  . GLU A 1 460 ? 207.568 186.652 124.539 1.00 87.80  ? 453 GLU B CB  1 
ATOM   3089 C  CG  . GLU A 1 460 ? 208.547 186.082 123.537 1.00 91.87  ? 453 GLU B CG  1 
ATOM   3090 C  CD  . GLU A 1 460 ? 209.950 185.995 124.091 1.00 102.70 ? 453 GLU B CD  1 
ATOM   3091 O  OE1 . GLU A 1 460 ? 210.261 186.746 125.038 1.00 100.22 ? 453 GLU B OE1 1 
ATOM   3092 O  OE2 . GLU A 1 460 ? 210.742 185.174 123.584 1.00 106.82 ? 453 GLU B OE2 1 
ATOM   3093 N  N   . TYR A 1 461 ? 205.224 187.308 126.253 1.00 83.68  ? 454 TYR B N   1 
ATOM   3094 C  CA  . TYR A 1 461 ? 204.418 188.227 127.034 1.00 82.86  ? 454 TYR B CA  1 
ATOM   3095 C  C   . TYR A 1 461 ? 205.312 188.865 128.084 1.00 84.38  ? 454 TYR B C   1 
ATOM   3096 O  O   . TYR A 1 461 ? 206.358 188.326 128.445 1.00 89.83  ? 454 TYR B O   1 
ATOM   3097 C  CB  . TYR A 1 461 ? 203.239 187.515 127.703 1.00 80.68  ? 454 TYR B CB  1 
ATOM   3098 C  CG  . TYR A 1 461 ? 201.935 187.643 126.957 1.00 80.91  ? 454 TYR B CG  1 
ATOM   3099 C  CD1 . TYR A 1 461 ? 201.636 186.802 125.899 1.00 81.56  ? 454 TYR B CD1 1 
ATOM   3100 C  CD2 . TYR A 1 461 ? 201.004 188.603 127.310 1.00 82.13  ? 454 TYR B CD2 1 
ATOM   3101 C  CE1 . TYR A 1 461 ? 200.446 186.914 125.215 1.00 83.61  ? 454 TYR B CE1 1 
ATOM   3102 C  CE2 . TYR A 1 461 ? 199.813 188.724 126.631 1.00 83.44  ? 454 TYR B CE2 1 
ATOM   3103 C  CZ  . TYR A 1 461 ? 199.538 187.878 125.586 1.00 83.19  ? 454 TYR B CZ  1 
ATOM   3104 O  OH  . TYR A 1 461 ? 198.348 187.997 124.910 1.00 78.55  ? 454 TYR B OH  1 
ATOM   3105 N  N   . ASP A 1 462 ? 204.897 190.028 128.566 1.00 83.01  ? 455 ASP B N   1 
ATOM   3106 C  CA  . ASP A 1 462 ? 205.622 190.754 129.598 1.00 84.93  ? 455 ASP B CA  1 
ATOM   3107 C  C   . ASP A 1 462 ? 204.717 190.889 130.811 1.00 82.09  ? 455 ASP B C   1 
ATOM   3108 O  O   . ASP A 1 462 ? 203.594 191.387 130.693 1.00 82.76  ? 455 ASP B O   1 
ATOM   3109 C  CB  . ASP A 1 462 ? 206.059 192.129 129.093 1.00 90.19  ? 455 ASP B CB  1 
ATOM   3110 C  CG  . ASP A 1 462 ? 207.466 192.488 129.517 1.00 93.56  ? 455 ASP B CG  1 
ATOM   3111 O  OD1 . ASP A 1 462 ? 208.339 191.595 129.519 1.00 93.34  ? 455 ASP B OD1 1 
ATOM   3112 O  OD2 . ASP A 1 462 ? 207.700 193.670 129.842 1.00 91.50  ? 455 ASP B OD2 1 
ATOM   3113 N  N   . LEU A 1 463 ? 205.197 190.443 131.967 1.00 79.43  ? 456 LEU B N   1 
ATOM   3114 C  CA  . LEU A 1 463 ? 204.428 190.562 133.199 1.00 77.53  ? 456 LEU B CA  1 
ATOM   3115 C  C   . LEU A 1 463 ? 204.683 191.931 133.816 1.00 77.64  ? 456 LEU B C   1 
ATOM   3116 O  O   . LEU A 1 463 ? 205.818 192.253 134.179 1.00 83.06  ? 456 LEU B O   1 
ATOM   3117 C  CB  . LEU A 1 463 ? 204.795 189.448 134.175 1.00 77.23  ? 456 LEU B CB  1 
ATOM   3118 C  CG  . LEU A 1 463 ? 204.106 189.518 135.537 1.00 74.89  ? 456 LEU B CG  1 
ATOM   3119 C  CD1 . LEU A 1 463 ? 202.660 189.099 135.420 1.00 69.99  ? 456 LEU B CD1 1 
ATOM   3120 C  CD2 . LEU A 1 463 ? 204.822 188.644 136.540 1.00 75.61  ? 456 LEU B CD2 1 
ATOM   3121 N  N   . LYS A 1 464 ? 203.634 192.735 133.932 1.00 72.10  ? 457 LYS B N   1 
ATOM   3122 C  CA  . LYS A 1 464 ? 203.751 194.101 134.408 1.00 76.32  ? 457 LYS B CA  1 
ATOM   3123 C  C   . LYS A 1 464 ? 202.893 194.301 135.646 1.00 75.88  ? 457 LYS B C   1 
ATOM   3124 O  O   . LYS A 1 464 ? 201.899 193.600 135.849 1.00 76.77  ? 457 LYS B O   1 
ATOM   3125 C  CB  . LYS A 1 464 ? 203.334 195.101 133.324 1.00 82.01  ? 457 LYS B CB  1 
ATOM   3126 C  CG  . LYS A 1 464 ? 203.845 194.766 131.936 1.00 84.64  ? 457 LYS B CG  1 
ATOM   3127 C  CD  . LYS A 1 464 ? 203.993 196.012 131.087 1.00 86.14  ? 457 LYS B CD  1 
ATOM   3128 C  CE  . LYS A 1 464 ? 205.303 196.003 130.322 1.00 90.70  ? 457 LYS B CE  1 
ATOM   3129 N  NZ  . LYS A 1 464 ? 205.589 197.319 129.687 1.00 95.23  ? 457 LYS B NZ  1 
ATOM   3130 N  N   . LEU A 1 465 ? 203.290 195.260 136.478 1.00 76.35  ? 458 LEU B N   1 
ATOM   3131 C  CA  . LEU A 1 465 ? 202.507 195.651 137.637 1.00 74.57  ? 458 LEU B CA  1 
ATOM   3132 C  C   . LEU A 1 465 ? 202.454 197.167 137.723 1.00 81.01  ? 458 LEU B C   1 
ATOM   3133 O  O   . LEU A 1 465 ? 203.338 197.864 137.224 1.00 86.56  ? 458 LEU B O   1 
ATOM   3134 C  CB  . LEU A 1 465 ? 203.076 195.082 138.938 1.00 70.40  ? 458 LEU B CB  1 
ATOM   3135 C  CG  . LEU A 1 465 ? 204.088 195.920 139.713 1.00 75.00  ? 458 LEU B CG  1 
ATOM   3136 C  CD1 . LEU A 1 465 ? 204.270 195.333 141.095 1.00 75.49  ? 458 LEU B CD1 1 
ATOM   3137 C  CD2 . LEU A 1 465 ? 205.412 195.997 138.986 1.00 76.54  ? 458 LEU B CD2 1 
ATOM   3138 N  N   . TRP A 1 466 ? 201.406 197.669 138.367 1.00 78.13  ? 459 TRP B N   1 
ATOM   3139 C  CA  . TRP A 1 466 ? 201.196 199.105 138.502 1.00 83.73  ? 459 TRP B CA  1 
ATOM   3140 C  C   . TRP A 1 466 ? 202.018 199.618 139.676 1.00 88.56  ? 459 TRP B C   1 
ATOM   3141 O  O   . TRP A 1 466 ? 201.753 199.262 140.827 1.00 90.69  ? 459 TRP B O   1 
ATOM   3142 C  CB  . TRP A 1 466 ? 199.715 199.405 138.704 1.00 85.35  ? 459 TRP B CB  1 
ATOM   3143 C  CG  . TRP A 1 466 ? 198.888 199.251 137.473 1.00 89.76  ? 459 TRP B CG  1 
ATOM   3144 C  CD1 . TRP A 1 466 ? 199.235 198.601 136.332 1.00 87.91  ? 459 TRP B CD1 1 
ATOM   3145 C  CD2 . TRP A 1 466 ? 197.564 199.753 137.263 1.00 94.19  ? 459 TRP B CD2 1 
ATOM   3146 N  NE1 . TRP A 1 466 ? 198.214 198.669 135.420 1.00 86.80  ? 459 TRP B NE1 1 
ATOM   3147 C  CE2 . TRP A 1 466 ? 197.174 199.370 135.969 1.00 89.14  ? 459 TRP B CE2 1 
ATOM   3148 C  CE3 . TRP A 1 466 ? 196.672 200.490 138.044 1.00 97.25  ? 459 TRP B CE3 1 
ATOM   3149 C  CZ2 . TRP A 1 466 ? 195.933 199.698 135.438 1.00 89.52  ? 459 TRP B CZ2 1 
ATOM   3150 C  CZ3 . TRP A 1 466 ? 195.440 200.814 137.513 1.00 96.31  ? 459 TRP B CZ3 1 
ATOM   3151 C  CH2 . TRP A 1 466 ? 195.082 200.420 136.224 1.00 91.28  ? 459 TRP B CH2 1 
ATOM   3152 N  N   . VAL A 1 467 ? 203.013 200.453 139.395 1.00 91.01  ? 460 VAL B N   1 
ATOM   3153 C  CA  . VAL A 1 467 ? 203.833 201.075 140.427 1.00 91.78  ? 460 VAL B CA  1 
ATOM   3154 C  C   . VAL A 1 467 ? 203.328 202.494 140.634 1.00 104.41 ? 460 VAL B C   1 
ATOM   3155 O  O   . VAL A 1 467 ? 203.397 203.325 139.722 1.00 108.68 ? 460 VAL B O   1 
ATOM   3156 C  CB  . VAL A 1 467 ? 205.320 201.072 140.045 1.00 89.14  ? 460 VAL B CB  1 
ATOM   3157 C  CG1 . VAL A 1 467 ? 206.117 201.863 141.057 1.00 91.65  ? 460 VAL B CG1 1 
ATOM   3158 C  CG2 . VAL A 1 467 ? 205.838 199.654 139.952 1.00 87.97  ? 460 VAL B CG2 1 
ATOM   3159 N  N   . TRP A 1 468 ? 202.833 202.779 141.834 1.00 109.75 ? 461 TRP B N   1 
ATOM   3160 C  CA  . TRP A 1 468 ? 202.197 204.056 142.124 1.00 111.57 ? 461 TRP B CA  1 
ATOM   3161 C  C   . TRP A 1 468 ? 203.239 205.092 142.513 1.00 118.64 ? 461 TRP B C   1 
ATOM   3162 O  O   . TRP A 1 468 ? 204.106 204.828 143.352 1.00 119.84 ? 461 TRP B O   1 
ATOM   3163 C  CB  . TRP A 1 468 ? 201.167 203.898 143.241 1.00 105.05 ? 461 TRP B CB  1 
ATOM   3164 C  CG  . TRP A 1 468 ? 199.997 203.098 142.816 1.00 104.24 ? 461 TRP B CG  1 
ATOM   3165 C  CD1 . TRP A 1 468 ? 199.821 201.759 142.976 1.00 105.83 ? 461 TRP B CD1 1 
ATOM   3166 C  CD2 . TRP A 1 468 ? 198.839 203.578 142.130 1.00 105.41 ? 461 TRP B CD2 1 
ATOM   3167 N  NE1 . TRP A 1 468 ? 198.617 201.373 142.442 1.00 107.67 ? 461 TRP B NE1 1 
ATOM   3168 C  CE2 . TRP A 1 468 ? 197.995 202.474 141.915 1.00 108.57 ? 461 TRP B CE2 1 
ATOM   3169 C  CE3 . TRP A 1 468 ? 198.432 204.835 141.681 1.00 106.32 ? 461 TRP B CE3 1 
ATOM   3170 C  CZ2 . TRP A 1 468 ? 196.770 202.589 141.269 1.00 107.83 ? 461 TRP B CZ2 1 
ATOM   3171 C  CZ3 . TRP A 1 468 ? 197.214 204.947 141.045 1.00 107.76 ? 461 TRP B CZ3 1 
ATOM   3172 C  CH2 . TRP A 1 468 ? 196.398 203.832 140.844 1.00 105.49 ? 461 TRP B CH2 1 
ATOM   3173 N  N   . GLN A 1 469 ? 203.149 206.270 141.902 1.00 122.08 ? 462 GLN B N   1 
ATOM   3174 C  CA  . GLN A 1 469 ? 204.067 207.364 142.203 1.00 127.10 ? 462 GLN B CA  1 
ATOM   3175 C  C   . GLN A 1 469 ? 203.381 208.665 141.816 1.00 132.27 ? 462 GLN B C   1 
ATOM   3176 O  O   . GLN A 1 469 ? 203.190 208.935 140.626 1.00 135.91 ? 462 GLN B O   1 
ATOM   3177 C  CB  . GLN A 1 469 ? 205.389 207.195 141.459 1.00 128.34 ? 462 GLN B CB  1 
ATOM   3178 C  CG  . GLN A 1 469 ? 206.476 208.151 141.909 1.00 131.94 ? 462 GLN B CG  1 
ATOM   3179 C  CD  . GLN A 1 469 ? 206.627 209.334 140.975 1.00 134.81 ? 462 GLN B CD  1 
ATOM   3180 O  OE1 . GLN A 1 469 ? 205.976 209.403 139.933 1.00 134.06 ? 462 GLN B OE1 1 
ATOM   3181 N  NE2 . GLN A 1 469 ? 207.491 210.273 141.344 1.00 132.91 ? 462 GLN B NE2 1 
ATOM   3182 N  N   . GLY A 1 470 ? 203.012 209.462 142.813 1.00 129.18 ? 463 GLY B N   1 
ATOM   3183 C  CA  . GLY A 1 470 ? 202.331 210.720 142.547 1.00 128.56 ? 463 GLY B CA  1 
ATOM   3184 C  C   . GLY A 1 470 ? 200.981 210.553 141.887 1.00 129.12 ? 463 GLY B C   1 
ATOM   3185 O  O   . GLY A 1 470 ? 200.622 211.342 141.004 1.00 127.42 ? 463 GLY B O   1 
ATOM   3186 N  N   . SER A 1 471 ? 200.225 209.531 142.292 1.00 129.23 ? 464 SER B N   1 
ATOM   3187 C  CA  . SER A 1 471 ? 198.892 209.238 141.766 1.00 127.65 ? 464 SER B CA  1 
ATOM   3188 C  C   . SER A 1 471 ? 198.894 209.016 140.256 1.00 126.93 ? 464 SER B C   1 
ATOM   3189 O  O   . SER A 1 471 ? 197.839 209.067 139.617 1.00 124.52 ? 464 SER B O   1 
ATOM   3190 C  CB  . SER A 1 471 ? 197.890 210.337 142.135 1.00 124.84 ? 464 SER B CB  1 
ATOM   3191 O  OG  . SER A 1 471 ? 196.560 209.852 142.081 1.00 119.65 ? 464 SER B OG  1 
ATOM   3192 N  N   . VAL A 1 472 ? 200.062 208.770 139.672 1.00 126.16 ? 465 VAL B N   1 
ATOM   3193 C  CA  . VAL A 1 472 ? 200.170 208.454 138.252 1.00 126.28 ? 465 VAL B CA  1 
ATOM   3194 C  C   . VAL A 1 472 ? 200.854 207.100 138.128 1.00 124.50 ? 465 VAL B C   1 
ATOM   3195 O  O   . VAL A 1 472 ? 202.090 207.033 138.066 1.00 124.74 ? 465 VAL B O   1 
ATOM   3196 C  CB  . VAL A 1 472 ? 200.940 209.540 137.485 1.00 125.44 ? 465 VAL B CB  1 
ATOM   3197 C  CG1 . VAL A 1 472 ? 200.910 209.254 135.992 1.00 120.58 ? 465 VAL B CG1 1 
ATOM   3198 C  CG2 . VAL A 1 472 ? 200.359 210.913 137.779 1.00 124.49 ? 465 VAL B CG2 1 
ATOM   3199 N  N   . PRO A 1 473 ? 200.102 206.004 138.099 1.00 120.67 ? 466 PRO B N   1 
ATOM   3200 C  CA  . PRO A 1 473 ? 200.732 204.684 138.035 1.00 116.11 ? 466 PRO B CA  1 
ATOM   3201 C  C   . PRO A 1 473 ? 201.444 204.468 136.712 1.00 114.79 ? 466 PRO B C   1 
ATOM   3202 O  O   . PRO A 1 473 ? 201.043 204.987 135.669 1.00 115.23 ? 466 PRO B O   1 
ATOM   3203 C  CB  . PRO A 1 473 ? 199.554 203.719 138.197 1.00 111.47 ? 466 PRO B CB  1 
ATOM   3204 C  CG  . PRO A 1 473 ? 198.373 204.481 137.744 1.00 111.77 ? 466 PRO B CG  1 
ATOM   3205 C  CD  . PRO A 1 473 ? 198.636 205.934 137.997 1.00 117.08 ? 466 PRO B CD  1 
ATOM   3206 N  N   . ARG A 1 474 ? 202.518 203.689 136.770 1.00 109.69 ? 467 ARG B N   1 
ATOM   3207 C  CA  . ARG A 1 474 ? 203.288 203.345 135.588 1.00 105.67 ? 467 ARG B CA  1 
ATOM   3208 C  C   . ARG A 1 474 ? 203.626 201.864 135.636 1.00 99.51  ? 467 ARG B C   1 
ATOM   3209 O  O   . ARG A 1 474 ? 203.698 201.264 136.711 1.00 97.80  ? 467 ARG B O   1 
ATOM   3210 C  CB  . ARG A 1 474 ? 204.570 204.178 135.481 1.00 109.40 ? 467 ARG B CB  1 
ATOM   3211 C  CG  . ARG A 1 474 ? 205.605 203.866 136.547 1.00 113.04 ? 467 ARG B CG  1 
ATOM   3212 C  CD  . ARG A 1 474 ? 206.436 205.090 136.889 1.00 120.87 ? 467 ARG B CD  1 
ATOM   3213 N  NE  . ARG A 1 474 ? 206.893 205.791 135.696 1.00 122.88 ? 467 ARG B NE  1 
ATOM   3214 C  CZ  . ARG A 1 474 ? 206.489 207.001 135.337 1.00 126.90 ? 467 ARG B CZ  1 
ATOM   3215 N  NH1 . ARG A 1 474 ? 205.615 207.681 136.061 1.00 126.62 ? 467 ARG B NH1 1 
ATOM   3216 N  NH2 . ARG A 1 474 ? 206.973 207.543 134.223 1.00 126.29 ? 467 ARG B NH2 1 
ATOM   3217 N  N   . LEU A 1 475 ? 203.828 201.281 134.462 1.00 95.42  ? 468 LEU B N   1 
ATOM   3218 C  CA  . LEU A 1 475 ? 204.126 199.862 134.370 1.00 93.83  ? 468 LEU B CA  1 
ATOM   3219 C  C   . LEU A 1 475 ? 205.604 199.600 134.631 1.00 96.97  ? 468 LEU B C   1 
ATOM   3220 O  O   . LEU A 1 475 ? 206.455 200.472 134.443 1.00 99.69  ? 468 LEU B O   1 
ATOM   3221 C  CB  . LEU A 1 475 ? 203.733 199.327 132.997 1.00 85.51  ? 468 LEU B CB  1 
ATOM   3222 C  CG  . LEU A 1 475 ? 202.243 199.423 132.687 1.00 84.52  ? 468 LEU B CG  1 
ATOM   3223 C  CD1 . LEU A 1 475 ? 202.012 199.257 131.205 1.00 86.24  ? 468 LEU B CD1 1 
ATOM   3224 C  CD2 . LEU A 1 475 ? 201.479 198.376 133.466 1.00 83.75  ? 468 LEU B CD2 1 
ATOM   3225 N  N   . HIS A 1 476 ? 205.900 198.383 135.079 1.00 92.06  ? 469 HIS B N   1 
ATOM   3226 C  CA  . HIS A 1 476 ? 207.272 197.966 135.331 1.00 90.56  ? 469 HIS B CA  1 
ATOM   3227 C  C   . HIS A 1 476 ? 207.412 196.492 134.988 1.00 89.90  ? 469 HIS B C   1 
ATOM   3228 O  O   . HIS A 1 476 ? 206.463 195.722 135.156 1.00 89.77  ? 469 HIS B O   1 
ATOM   3229 C  CB  . HIS A 1 476 ? 207.669 198.212 136.790 1.00 89.78  ? 469 HIS B CB  1 
ATOM   3230 C  CG  . HIS A 1 476 ? 208.328 199.536 137.025 1.00 99.28  ? 469 HIS B CG  1 
ATOM   3231 N  ND1 . HIS A 1 476 ? 209.696 199.684 137.089 1.00 102.60 ? 469 HIS B ND1 1 
ATOM   3232 C  CD2 . HIS A 1 476 ? 207.807 200.771 137.216 1.00 101.58 ? 469 HIS B CD2 1 
ATOM   3233 C  CE1 . HIS A 1 476 ? 209.990 200.953 137.308 1.00 102.98 ? 469 HIS B CE1 1 
ATOM   3234 N  NE2 . HIS A 1 476 ? 208.861 201.634 137.389 1.00 100.51 ? 469 HIS B NE2 1 
ATOM   3235 N  N   . ASP A 1 477 ? 208.589 196.107 134.508 1.00 89.25  ? 470 ASP B N   1 
ATOM   3236 C  CA  . ASP A 1 477 ? 208.869 194.714 134.180 1.00 88.15  ? 470 ASP B CA  1 
ATOM   3237 C  C   . ASP A 1 477 ? 209.192 193.946 135.454 1.00 89.43  ? 470 ASP B C   1 
ATOM   3238 O  O   . ASP A 1 477 ? 210.116 194.310 136.187 1.00 93.50  ? 470 ASP B O   1 
ATOM   3239 C  CB  . ASP A 1 477 ? 210.029 194.631 133.193 1.00 93.87  ? 470 ASP B CB  1 
ATOM   3240 C  CG  . ASP A 1 477 ? 210.041 193.334 132.410 1.00 95.71  ? 470 ASP B CG  1 
ATOM   3241 O  OD1 . ASP A 1 477 ? 210.075 193.388 131.163 1.00 92.49  ? 470 ASP B OD1 1 
ATOM   3242 O  OD2 . ASP A 1 477 ? 210.020 192.258 133.041 1.00 97.56  ? 470 ASP B OD2 1 
ATOM   3243 N  N   . VAL A 1 478 ? 208.434 192.884 135.727 1.00 83.31  ? 471 VAL B N   1 
ATOM   3244 C  CA  . VAL A 1 478 ? 208.721 191.990 136.839 1.00 79.71  ? 471 VAL B CA  1 
ATOM   3245 C  C   . VAL A 1 478 ? 208.679 190.527 136.426 1.00 80.33  ? 471 VAL B C   1 
ATOM   3246 O  O   . VAL A 1 478 ? 208.850 189.646 137.266 1.00 83.96  ? 471 VAL B O   1 
ATOM   3247 C  CB  . VAL A 1 478 ? 207.769 192.242 138.022 1.00 75.41  ? 471 VAL B CB  1 
ATOM   3248 C  CG1 . VAL A 1 478 ? 208.044 193.595 138.635 1.00 80.50  ? 471 VAL B CG1 1 
ATOM   3249 C  CG2 . VAL A 1 478 ? 206.335 192.137 137.564 1.00 76.28  ? 471 VAL B CG2 1 
ATOM   3250 N  N   . GLY A 1 479 ? 208.460 190.249 135.150 1.00 79.05  ? 472 GLY B N   1 
ATOM   3251 C  CA  . GLY A 1 479 ? 208.408 188.878 134.688 1.00 78.23  ? 472 GLY B CA  1 
ATOM   3252 C  C   . GLY A 1 479 ? 208.267 188.842 133.183 1.00 81.15  ? 472 GLY B C   1 
ATOM   3253 O  O   . GLY A 1 479 ? 207.969 189.853 132.540 1.00 85.67  ? 472 GLY B O   1 
ATOM   3254 N  N   . ARG A 1 480 ? 208.484 187.651 132.633 1.00 82.33  ? 473 ARG B N   1 
ATOM   3255 C  CA  . ARG A 1 480 ? 208.439 187.443 131.192 1.00 81.10  ? 473 ARG B CA  1 
ATOM   3256 C  C   . ARG A 1 480 ? 207.947 186.033 130.920 1.00 79.26  ? 473 ARG B C   1 
ATOM   3257 O  O   . ARG A 1 480 ? 208.596 185.064 131.318 1.00 84.93  ? 473 ARG B O   1 
ATOM   3258 C  CB  . ARG A 1 480 ? 209.814 187.655 130.559 1.00 83.46  ? 473 ARG B CB  1 
ATOM   3259 C  CG  . ARG A 1 480 ? 209.923 187.127 129.147 1.00 89.00  ? 473 ARG B CG  1 
ATOM   3260 C  CD  . ARG A 1 480 ? 209.858 188.259 128.139 1.00 95.62  ? 473 ARG B CD  1 
ATOM   3261 N  NE  . ARG A 1 480 ? 210.853 189.285 128.419 1.00 101.34 ? 473 ARG B NE  1 
ATOM   3262 C  CZ  . ARG A 1 480 ? 212.112 189.233 128.008 1.00 103.91 ? 473 ARG B CZ  1 
ATOM   3263 N  NH1 . ARG A 1 480 ? 212.561 188.223 127.281 1.00 98.89  ? 473 ARG B NH1 1 
ATOM   3264 N  NH2 . ARG A 1 480 ? 212.943 190.218 128.337 1.00 106.64 ? 473 ARG B NH2 1 
ATOM   3265 N  N   . PHE A 1 481 ? 206.815 185.920 130.239 1.00 76.31  ? 474 PHE B N   1 
ATOM   3266 C  CA  . PHE A 1 481 ? 206.216 184.632 129.928 1.00 77.57  ? 474 PHE B CA  1 
ATOM   3267 C  C   . PHE A 1 481 ? 206.512 184.275 128.480 1.00 82.87  ? 474 PHE B C   1 
ATOM   3268 O  O   . PHE A 1 481 ? 206.210 185.052 127.573 1.00 91.53  ? 474 PHE B O   1 
ATOM   3269 C  CB  . PHE A 1 481 ? 204.709 184.665 130.164 1.00 76.18  ? 474 PHE B CB  1 
ATOM   3270 C  CG  . PHE A 1 481 ? 204.031 183.358 129.907 1.00 79.60  ? 474 PHE B CG  1 
ATOM   3271 C  CD1 . PHE A 1 481 ? 204.023 182.369 130.870 1.00 80.55  ? 474 PHE B CD1 1 
ATOM   3272 C  CD2 . PHE A 1 481 ? 203.398 183.117 128.706 1.00 82.64  ? 474 PHE B CD2 1 
ATOM   3273 C  CE1 . PHE A 1 481 ? 203.398 181.166 130.638 1.00 81.54  ? 474 PHE B CE1 1 
ATOM   3274 C  CE2 . PHE A 1 481 ? 202.774 181.914 128.470 1.00 85.74  ? 474 PHE B CE2 1 
ATOM   3275 C  CZ  . PHE A 1 481 ? 202.775 180.937 129.438 1.00 83.48  ? 474 PHE B CZ  1 
ATOM   3276 N  N   . ASN A 1 482 ? 207.102 183.104 128.268 1.00 84.08  ? 475 ASN B N   1 
ATOM   3277 C  CA  . ASN A 1 482 ? 207.438 182.634 126.930 1.00 88.56  ? 475 ASN B CA  1 
ATOM   3278 C  C   . ASN A 1 482 ? 207.099 181.160 126.794 1.00 90.69  ? 475 ASN B C   1 
ATOM   3279 O  O   . ASN A 1 482 ? 207.790 180.403 126.105 1.00 93.09  ? 475 ASN B O   1 
ATOM   3280 C  CB  . ASN A 1 482 ? 208.910 182.884 126.614 1.00 96.42  ? 475 ASN B CB  1 
ATOM   3281 C  CG  . ASN A 1 482 ? 209.838 182.108 127.519 1.00 102.73 ? 475 ASN B CG  1 
ATOM   3282 O  OD1 . ASN A 1 482 ? 209.706 182.145 128.741 1.00 101.27 ? 475 ASN B OD1 1 
ATOM   3283 N  ND2 . ASN A 1 482 ? 210.785 181.399 126.924 1.00 104.44 ? 475 ASN B ND2 1 
ATOM   3284 N  N   . GLY A 1 483 ? 206.017 180.737 127.441 1.00 90.70  ? 476 GLY B N   1 
ATOM   3285 C  CA  . GLY A 1 483 ? 205.678 179.343 127.585 1.00 91.99  ? 476 GLY B CA  1 
ATOM   3286 C  C   . GLY A 1 483 ? 206.065 178.752 128.924 1.00 91.71  ? 476 GLY B C   1 
ATOM   3287 O  O   . GLY A 1 483 ? 205.528 177.707 129.307 1.00 94.26  ? 476 GLY B O   1 
ATOM   3288 N  N   . SER A 1 484 ? 206.978 179.399 129.643 1.00 91.65  ? 477 SER B N   1 
ATOM   3289 C  CA  . SER A 1 484 ? 207.347 178.989 130.994 1.00 92.47  ? 477 SER B CA  1 
ATOM   3290 C  C   . SER A 1 484 ? 207.677 180.258 131.765 1.00 92.47  ? 477 SER B C   1 
ATOM   3291 O  O   . SER A 1 484 ? 208.700 180.895 131.500 1.00 93.76  ? 477 SER B O   1 
ATOM   3292 C  CB  . SER A 1 484 ? 208.527 178.023 130.980 1.00 98.14  ? 477 SER B CB  1 
ATOM   3293 O  OG  . SER A 1 484 ? 209.587 178.520 130.183 1.00 102.65 ? 477 SER B OG  1 
ATOM   3294 N  N   . LEU A 1 485 ? 206.813 180.620 132.708 1.00 90.46  ? 478 LEU B N   1 
ATOM   3295 C  CA  . LEU A 1 485 ? 206.914 181.912 133.369 1.00 85.61  ? 478 LEU B CA  1 
ATOM   3296 C  C   . LEU A 1 485 ? 208.176 182.012 134.216 1.00 84.40  ? 478 LEU B C   1 
ATOM   3297 O  O   . LEU A 1 485 ? 208.553 181.071 134.918 1.00 85.70  ? 478 LEU B O   1 
ATOM   3298 C  CB  . LEU A 1 485 ? 205.683 182.149 134.237 1.00 78.59  ? 478 LEU B CB  1 
ATOM   3299 C  CG  . LEU A 1 485 ? 205.748 183.305 135.226 1.00 72.66  ? 478 LEU B CG  1 
ATOM   3300 C  CD1 . LEU A 1 485 ? 205.240 184.569 134.585 1.00 76.64  ? 478 LEU B CD1 1 
ATOM   3301 C  CD2 . LEU A 1 485 ? 204.933 182.971 136.452 1.00 74.00  ? 478 LEU B CD2 1 
ATOM   3302 N  N   . ARG A 1 486 ? 208.835 183.165 134.135 1.00 82.64  ? 479 ARG B N   1 
ATOM   3303 C  CA  . ARG A 1 486 ? 209.961 183.506 134.993 1.00 82.61  ? 479 ARG B CA  1 
ATOM   3304 C  C   . ARG A 1 486 ? 209.686 184.860 135.623 1.00 85.30  ? 479 ARG B C   1 
ATOM   3305 O  O   . ARG A 1 486 ? 209.409 185.828 134.911 1.00 89.98  ? 479 ARG B O   1 
ATOM   3306 C  CB  . ARG A 1 486 ? 211.271 183.546 134.207 1.00 85.43  ? 479 ARG B CB  1 
ATOM   3307 C  CG  . ARG A 1 486 ? 212.429 184.156 134.974 1.00 88.48  ? 479 ARG B CG  1 
ATOM   3308 C  CD  . ARG A 1 486 ? 213.232 185.112 134.107 1.00 93.33  ? 479 ARG B CD  1 
ATOM   3309 N  NE  . ARG A 1 486 ? 212.788 186.493 134.254 1.00 98.32  ? 479 ARG B NE  1 
ATOM   3310 C  CZ  . ARG A 1 486 ? 212.957 187.436 133.338 1.00 99.28  ? 479 ARG B CZ  1 
ATOM   3311 N  NH1 . ARG A 1 486 ? 213.558 187.183 132.187 1.00 97.32  ? 479 ARG B NH1 1 
ATOM   3312 N  NH2 . ARG A 1 486 ? 212.512 188.665 133.582 1.00 94.56  ? 479 ARG B NH2 1 
ATOM   3313 N  N   . THR A 1 487 ? 209.766 184.933 136.948 1.00 86.63  ? 480 THR B N   1 
ATOM   3314 C  CA  . THR A 1 487 ? 209.440 186.151 137.672 1.00 88.87  ? 480 THR B CA  1 
ATOM   3315 C  C   . THR A 1 487 ? 210.597 186.543 138.575 1.00 91.21  ? 480 THR B C   1 
ATOM   3316 O  O   . THR A 1 487 ? 211.425 185.713 138.959 1.00 94.94  ? 480 THR B O   1 
ATOM   3317 C  CB  . THR A 1 487 ? 208.171 185.998 138.518 1.00 83.78  ? 480 THR B CB  1 
ATOM   3318 O  OG1 . THR A 1 487 ? 208.295 184.851 139.364 1.00 84.34  ? 480 THR B OG1 1 
ATOM   3319 C  CG2 . THR A 1 487 ? 206.955 185.839 137.630 1.00 77.42  ? 480 THR B CG2 1 
ATOM   3320 N  N   . GLU A 1 488 ? 210.642 187.828 138.910 1.00 87.95  ? 481 GLU B N   1 
ATOM   3321 C  CA  . GLU A 1 488 ? 211.631 188.384 139.826 1.00 90.47  ? 481 GLU B CA  1 
ATOM   3322 C  C   . GLU A 1 488 ? 210.862 189.015 140.981 1.00 90.35  ? 481 GLU B C   1 
ATOM   3323 O  O   . GLU A 1 488 ? 210.590 190.217 140.975 1.00 94.30  ? 481 GLU B O   1 
ATOM   3324 C  CB  . GLU A 1 488 ? 212.519 189.393 139.117 1.00 89.59  ? 481 GLU B CB  1 
ATOM   3325 C  CG  . GLU A 1 488 ? 213.423 188.779 138.067 1.00 94.49  ? 481 GLU B CG  1 
ATOM   3326 C  CD  . GLU A 1 488 ? 214.777 188.384 138.620 1.00 103.25 ? 481 GLU B CD  1 
ATOM   3327 O  OE1 . GLU A 1 488 ? 215.064 188.720 139.787 1.00 104.60 ? 481 GLU B OE1 1 
ATOM   3328 O  OE2 . GLU A 1 488 ? 215.555 187.737 137.888 1.00 104.54 ? 481 GLU B OE2 1 
ATOM   3329 N  N   . ARG A 1 489 ? 210.524 188.203 141.981 1.00 86.10  ? 482 ARG B N   1 
ATOM   3330 C  CA  . ARG A 1 489 ? 209.686 188.669 143.078 1.00 88.63  ? 482 ARG B CA  1 
ATOM   3331 C  C   . ARG A 1 489 ? 210.448 189.502 144.098 1.00 95.83  ? 482 ARG B C   1 
ATOM   3332 O  O   . ARG A 1 489 ? 209.831 190.013 145.039 1.00 93.24  ? 482 ARG B O   1 
ATOM   3333 C  CB  . ARG A 1 489 ? 209.027 187.483 143.780 1.00 85.89  ? 482 ARG B CB  1 
ATOM   3334 C  CG  . ARG A 1 489 ? 210.000 186.412 144.213 1.00 88.74  ? 482 ARG B CG  1 
ATOM   3335 C  CD  . ARG A 1 489 ? 209.299 185.320 144.992 1.00 84.80  ? 482 ARG B CD  1 
ATOM   3336 N  NE  . ARG A 1 489 ? 208.982 184.184 144.138 1.00 89.65  ? 482 ARG B NE  1 
ATOM   3337 C  CZ  . ARG A 1 489 ? 208.161 183.202 144.475 1.00 90.78  ? 482 ARG B CZ  1 
ATOM   3338 N  NH1 . ARG A 1 489 ? 207.548 183.186 145.647 1.00 89.77  ? 482 ARG B NH1 1 
ATOM   3339 N  NH2 . ARG A 1 489 ? 207.950 182.209 143.616 1.00 88.38  ? 482 ARG B NH2 1 
ATOM   3340 N  N   . LEU A 1 490 ? 211.763 189.643 143.945 1.00 99.80  ? 483 LEU B N   1 
ATOM   3341 C  CA  . LEU A 1 490 ? 212.552 190.452 144.862 1.00 93.41  ? 483 LEU B CA  1 
ATOM   3342 C  C   . LEU A 1 490 ? 212.461 191.940 144.564 1.00 90.06  ? 483 LEU B C   1 
ATOM   3343 O  O   . LEU A 1 490 ? 213.020 192.740 145.321 1.00 89.41  ? 483 LEU B O   1 
ATOM   3344 C  CB  . LEU A 1 490 ? 214.022 190.019 144.834 1.00 92.87  ? 483 LEU B CB  1 
ATOM   3345 C  CG  . LEU A 1 490 ? 214.378 188.552 145.113 1.00 96.80  ? 483 LEU B CG  1 
ATOM   3346 C  CD1 . LEU A 1 490 ? 213.682 188.064 146.381 1.00 91.49  ? 483 LEU B CD1 1 
ATOM   3347 C  CD2 . LEU A 1 490 ? 214.115 187.617 143.927 1.00 93.44  ? 483 LEU B CD2 1 
ATOM   3348 N  N   . LYS A 1 491 ? 211.784 192.330 143.484 1.00 89.16  ? 484 LYS B N   1 
ATOM   3349 C  CA  . LYS A 1 491 ? 211.621 193.734 143.133 1.00 87.61  ? 484 LYS B CA  1 
ATOM   3350 C  C   . LYS A 1 491 ? 210.159 194.148 143.045 1.00 88.38  ? 484 LYS B C   1 
ATOM   3351 O  O   . LYS A 1 491 ? 209.869 195.260 142.592 1.00 92.47  ? 484 LYS B O   1 
ATOM   3352 C  CB  . LYS A 1 491 ? 212.323 194.037 141.807 1.00 87.09  ? 484 LYS B CB  1 
ATOM   3353 C  CG  . LYS A 1 491 ? 211.673 193.383 140.602 1.00 86.60  ? 484 LYS B CG  1 
ATOM   3354 C  CD  . LYS A 1 491 ? 212.058 194.089 139.311 1.00 88.54  ? 484 LYS B CD  1 
ATOM   3355 C  CE  . LYS A 1 491 ? 212.639 193.110 138.303 1.00 92.63  ? 484 LYS B CE  1 
ATOM   3356 N  NZ  . LYS A 1 491 ? 213.111 193.790 137.066 1.00 88.26  ? 484 LYS B NZ  1 
ATOM   3357 N  N   . ILE A 1 492 ? 209.234 193.294 143.467 1.00 83.71  ? 485 ILE B N   1 
ATOM   3358 C  CA  . ILE A 1 492 ? 207.810 193.596 143.400 1.00 79.74  ? 485 ILE B CA  1 
ATOM   3359 C  C   . ILE A 1 492 ? 207.406 194.312 144.680 1.00 83.49  ? 485 ILE B C   1 
ATOM   3360 O  O   . ILE A 1 492 ? 207.638 193.806 145.781 1.00 88.33  ? 485 ILE B O   1 
ATOM   3361 C  CB  . ILE A 1 492 ? 206.980 192.321 143.205 1.00 78.31  ? 485 ILE B CB  1 
ATOM   3362 C  CG1 . ILE A 1 492 ? 207.368 191.622 141.904 1.00 82.01  ? 485 ILE B CG1 1 
ATOM   3363 C  CG2 . ILE A 1 492 ? 205.504 192.647 143.229 1.00 77.97  ? 485 ILE B CG2 1 
ATOM   3364 C  CD1 . ILE A 1 492 ? 206.463 190.467 141.543 1.00 78.76  ? 485 ILE B CD1 1 
ATOM   3365 N  N   . ARG A 1 493 ? 206.801 195.487 144.538 1.00 81.91  ? 486 ARG B N   1 
ATOM   3366 C  CA  . ARG A 1 493 ? 206.310 196.247 145.682 1.00 84.13  ? 486 ARG B CA  1 
ATOM   3367 C  C   . ARG A 1 493 ? 204.851 195.877 145.910 1.00 86.61  ? 486 ARG B C   1 
ATOM   3368 O  O   . ARG A 1 493 ? 203.991 196.168 145.073 1.00 87.07  ? 486 ARG B O   1 
ATOM   3369 C  CB  . ARG A 1 493 ? 206.471 197.746 145.447 1.00 83.15  ? 486 ARG B CB  1 
ATOM   3370 C  CG  . ARG A 1 493 ? 205.540 198.610 146.278 1.00 85.46  ? 486 ARG B CG  1 
ATOM   3371 C  CD  . ARG A 1 493 ? 206.087 198.829 147.675 1.00 88.75  ? 486 ARG B CD  1 
ATOM   3372 N  NE  . ARG A 1 493 ? 205.849 200.187 148.148 1.00 96.65  ? 486 ARG B NE  1 
ATOM   3373 C  CZ  . ARG A 1 493 ? 204.767 200.573 148.811 1.00 102.14 ? 486 ARG B CZ  1 
ATOM   3374 N  NH1 . ARG A 1 493 ? 203.793 199.726 149.100 1.00 98.00  ? 486 ARG B NH1 1 
ATOM   3375 N  NH2 . ARG A 1 493 ? 204.659 201.842 149.194 1.00 106.23 ? 486 ARG B NH2 1 
ATOM   3376 N  N   . TRP A 1 494 ? 204.572 195.234 147.036 1.00 86.32  ? 487 TRP B N   1 
ATOM   3377 C  CA  . TRP A 1 494 ? 203.224 194.789 147.344 1.00 83.82  ? 487 TRP B CA  1 
ATOM   3378 C  C   . TRP A 1 494 ? 202.445 195.898 148.042 1.00 86.03  ? 487 TRP B C   1 
ATOM   3379 O  O   . TRP A 1 494 ? 202.976 196.959 148.368 1.00 91.13  ? 487 TRP B O   1 
ATOM   3380 C  CB  . TRP A 1 494 ? 203.262 193.528 148.204 1.00 83.01  ? 487 TRP B CB  1 
ATOM   3381 C  CG  . TRP A 1 494 ? 203.829 192.349 147.493 1.00 78.07  ? 487 TRP B CG  1 
ATOM   3382 C  CD1 . TRP A 1 494 ? 205.035 191.762 147.718 1.00 78.93  ? 487 TRP B CD1 1 
ATOM   3383 C  CD2 . TRP A 1 494 ? 203.212 191.607 146.438 1.00 74.49  ? 487 TRP B CD2 1 
ATOM   3384 N  NE1 . TRP A 1 494 ? 205.209 190.700 146.868 1.00 77.16  ? 487 TRP B NE1 1 
ATOM   3385 C  CE2 . TRP A 1 494 ? 204.101 190.585 146.071 1.00 74.99  ? 487 TRP B CE2 1 
ATOM   3386 C  CE3 . TRP A 1 494 ? 201.991 191.708 145.769 1.00 72.12  ? 487 TRP B CE3 1 
ATOM   3387 C  CZ2 . TRP A 1 494 ? 203.810 189.673 145.067 1.00 71.95  ? 487 TRP B CZ2 1 
ATOM   3388 C  CZ3 . TRP A 1 494 ? 201.706 190.803 144.776 1.00 67.42  ? 487 TRP B CZ3 1 
ATOM   3389 C  CH2 . TRP A 1 494 ? 202.609 189.799 144.433 1.00 67.14  ? 487 TRP B CH2 1 
ATOM   3390 N  N   . HIS A 1 495 ? 201.160 195.642 148.265 1.00 82.32  ? 488 HIS B N   1 
ATOM   3391 C  CA  . HIS A 1 495 ? 200.254 196.643 148.804 1.00 82.39  ? 488 HIS B CA  1 
ATOM   3392 C  C   . HIS A 1 495 ? 200.024 196.517 150.302 1.00 86.58  ? 488 HIS B C   1 
ATOM   3393 O  O   . HIS A 1 495 ? 199.388 197.397 150.887 1.00 86.85  ? 488 HIS B O   1 
ATOM   3394 C  CB  . HIS A 1 495 ? 198.911 196.566 148.086 1.00 82.98  ? 488 HIS B CB  1 
ATOM   3395 C  CG  . HIS A 1 495 ? 198.194 195.269 148.288 1.00 85.49  ? 488 HIS B CG  1 
ATOM   3396 N  ND1 . HIS A 1 495 ? 197.421 195.012 149.398 1.00 88.26  ? 488 HIS B ND1 1 
ATOM   3397 C  CD2 . HIS A 1 495 ? 198.129 194.158 147.519 1.00 81.67  ? 488 HIS B CD2 1 
ATOM   3398 C  CE1 . HIS A 1 495 ? 196.913 193.796 149.306 1.00 84.66  ? 488 HIS B CE1 1 
ATOM   3399 N  NE2 . HIS A 1 495 ? 197.327 193.257 148.175 1.00 81.57  ? 488 HIS B NE2 1 
ATOM   3400 N  N   . THR A 1 496 ? 200.519 195.460 150.938 1.00 88.48  ? 489 THR B N   1 
ATOM   3401 C  CA  . THR A 1 496 ? 200.223 195.235 152.344 1.00 92.15  ? 489 THR B CA  1 
ATOM   3402 C  C   . THR A 1 496 ? 200.986 196.233 153.216 1.00 98.26  ? 489 THR B C   1 
ATOM   3403 O  O   . THR A 1 496 ? 201.659 197.146 152.728 1.00 101.79 ? 489 THR B O   1 
ATOM   3404 C  CB  . THR A 1 496 ? 200.549 193.797 152.735 1.00 88.52  ? 489 THR B CB  1 
ATOM   3405 O  OG1 . THR A 1 496 ? 201.773 193.394 152.112 1.00 88.36  ? 489 THR B OG1 1 
ATOM   3406 C  CG2 . THR A 1 496 ? 199.435 192.869 152.297 1.00 84.27  ? 489 THR B CG2 1 
ATOM   3407 N  N   . SER A 1 497 ? 200.863 196.056 154.535 1.00 95.51  ? 490 SER B N   1 
ATOM   3408 C  CA  . SER A 1 497 ? 201.484 196.987 155.472 1.00 94.41  ? 490 SER B CA  1 
ATOM   3409 C  C   . SER A 1 497 ? 202.992 197.046 155.275 1.00 95.02  ? 490 SER B C   1 
ATOM   3410 O  O   . SER A 1 497 ? 203.579 198.133 155.230 1.00 94.92  ? 490 SER B O   1 
ATOM   3411 C  CB  . SER A 1 497 ? 201.144 196.586 156.906 1.00 92.29  ? 490 SER B CB  1 
ATOM   3412 O  OG  . SER A 1 497 ? 199.742 196.530 157.095 1.00 88.79  ? 490 SER B OG  1 
ATOM   3413 N  N   . ASP A 1 498 ? 203.634 195.895 155.150 1.00 96.43  ? 491 ASP B N   1 
ATOM   3414 C  CA  . ASP A 1 498 ? 205.031 195.805 154.761 1.00 100.55 ? 491 ASP B CA  1 
ATOM   3415 C  C   . ASP A 1 498 ? 205.120 195.106 153.408 1.00 103.49 ? 491 ASP B C   1 
ATOM   3416 O  O   . ASP A 1 498 ? 204.112 194.703 152.826 1.00 101.47 ? 491 ASP B O   1 
ATOM   3417 C  CB  . ASP A 1 498 ? 205.854 195.079 155.829 1.00 98.71  ? 491 ASP B CB  1 
ATOM   3418 C  CG  . ASP A 1 498 ? 205.401 193.653 156.045 1.00 100.40 ? 491 ASP B CG  1 
ATOM   3419 O  OD1 . ASP A 1 498 ? 204.265 193.454 156.521 1.00 101.85 ? 491 ASP B OD1 1 
ATOM   3420 O  OD2 . ASP A 1 498 ? 206.182 192.728 155.739 1.00 99.73  ? 491 ASP B OD2 1 
ATOM   3421 N  N   . ASN A 1 499 ? 206.342 194.968 152.900 1.00 103.73 ? 492 ASN B N   1 
ATOM   3422 C  CA  . ASN A 1 499 ? 206.559 194.380 151.578 1.00 98.97  ? 492 ASN B CA  1 
ATOM   3423 C  C   . ASN A 1 499 ? 206.598 192.857 151.694 1.00 96.51  ? 492 ASN B C   1 
ATOM   3424 O  O   . ASN A 1 499 ? 207.616 192.201 151.476 1.00 98.91  ? 492 ASN B O   1 
ATOM   3425 C  CB  . ASN A 1 499 ? 207.835 194.930 150.957 1.00 99.77  ? 492 ASN B CB  1 
ATOM   3426 C  CG  . ASN A 1 499 ? 207.630 195.410 149.538 1.00 97.27  ? 492 ASN B CG  1 
ATOM   3427 O  OD1 . ASN A 1 499 ? 206.619 196.037 149.225 1.00 95.45  ? 492 ASN B OD1 1 
ATOM   3428 N  ND2 . ASN A 1 499 ? 208.591 195.121 148.670 1.00 93.69  ? 492 ASN B ND2 1 
ATOM   3429 N  N   . GLN A 1 500 ? 205.446 192.296 152.047 1.00 92.31  ? 493 GLN B N   1 
ATOM   3430 C  CA  . GLN A 1 500 ? 205.286 190.858 152.186 1.00 89.97  ? 493 GLN B CA  1 
ATOM   3431 C  C   . GLN A 1 500 ? 204.200 190.373 151.237 1.00 89.16  ? 493 GLN B C   1 
ATOM   3432 O  O   . GLN A 1 500 ? 203.201 191.064 151.015 1.00 90.22  ? 493 GLN B O   1 
ATOM   3433 C  CB  . GLN A 1 500 ? 204.949 190.473 153.630 1.00 89.50  ? 493 GLN B CB  1 
ATOM   3434 C  CG  . GLN A 1 500 ? 203.667 191.082 154.164 1.00 93.58  ? 493 GLN B CG  1 
ATOM   3435 C  CD  . GLN A 1 500 ? 203.206 190.425 155.450 1.00 98.71  ? 493 GLN B CD  1 
ATOM   3436 O  OE1 . GLN A 1 500 ? 204.011 190.128 156.331 1.00 100.90 ? 493 GLN B OE1 1 
ATOM   3437 N  NE2 . GLN A 1 500 ? 201.903 190.194 155.563 1.00 94.57  ? 493 GLN B NE2 1 
ATOM   3438 N  N   . LYS A 1 501 ? 204.411 189.191 150.672 1.00 85.02  ? 494 LYS B N   1 
ATOM   3439 C  CA  . LYS A 1 501 ? 203.496 188.664 149.667 1.00 77.92  ? 494 LYS B CA  1 
ATOM   3440 C  C   . LYS A 1 501 ? 202.160 188.310 150.306 1.00 74.96  ? 494 LYS B C   1 
ATOM   3441 O  O   . LYS A 1 501 ? 202.134 187.613 151.324 1.00 74.97  ? 494 LYS B O   1 
ATOM   3442 C  CB  . LYS A 1 501 ? 204.097 187.434 148.995 1.00 75.04  ? 494 LYS B CB  1 
ATOM   3443 C  CG  . LYS A 1 501 ? 203.098 186.613 148.206 1.00 73.85  ? 494 LYS B CG  1 
ATOM   3444 C  CD  . LYS A 1 501 ? 203.772 185.452 147.500 1.00 74.89  ? 494 LYS B CD  1 
ATOM   3445 C  CE  . LYS A 1 501 ? 203.735 184.194 148.348 1.00 77.04  ? 494 LYS B CE  1 
ATOM   3446 N  NZ  . LYS A 1 501 ? 202.351 183.680 148.518 1.00 73.69  ? 494 LYS B NZ  1 
ATOM   3447 N  N   . PRO A 1 502 ? 201.041 188.775 149.756 1.00 73.43  ? 495 PRO B N   1 
ATOM   3448 C  CA  . PRO A 1 502 ? 199.738 188.372 150.292 1.00 76.37  ? 495 PRO B CA  1 
ATOM   3449 C  C   . PRO A 1 502 ? 199.550 186.868 150.182 1.00 78.39  ? 495 PRO B C   1 
ATOM   3450 O  O   . PRO A 1 502 ? 199.940 186.247 149.193 1.00 78.60  ? 495 PRO B O   1 
ATOM   3451 C  CB  . PRO A 1 502 ? 198.741 189.129 149.409 1.00 75.98  ? 495 PRO B CB  1 
ATOM   3452 C  CG  . PRO A 1 502 ? 199.524 190.231 148.798 1.00 73.31  ? 495 PRO B CG  1 
ATOM   3453 C  CD  . PRO A 1 502 ? 200.906 189.704 148.625 1.00 73.37  ? 495 PRO B CD  1 
ATOM   3454 N  N   . VAL A 1 503 ? 198.939 186.284 151.207 1.00 77.63  ? 496 VAL B N   1 
ATOM   3455 C  CA  . VAL A 1 503 ? 198.735 184.844 151.282 1.00 77.39  ? 496 VAL B CA  1 
ATOM   3456 C  C   . VAL A 1 503 ? 197.261 184.560 151.042 1.00 77.54  ? 496 VAL B C   1 
ATOM   3457 O  O   . VAL A 1 503 ? 196.392 185.089 151.745 1.00 80.02  ? 496 VAL B O   1 
ATOM   3458 C  CB  . VAL A 1 503 ? 199.209 184.269 152.625 1.00 77.81  ? 496 VAL B CB  1 
ATOM   3459 C  CG1 . VAL A 1 503 ? 200.722 184.278 152.692 1.00 74.42  ? 496 VAL B CG1 1 
ATOM   3460 C  CG2 . VAL A 1 503 ? 198.644 185.068 153.784 1.00 81.76  ? 496 VAL B CG2 1 
ATOM   3461 N  N   . SER A 1 504 ? 196.980 183.748 150.027 1.00 78.68  ? 497 SER B N   1 
ATOM   3462 C  CA  . SER A 1 504 ? 195.631 183.280 149.720 1.00 76.53  ? 497 SER B CA  1 
ATOM   3463 C  C   . SER A 1 504 ? 195.752 181.794 149.415 1.00 74.67  ? 497 SER B C   1 
ATOM   3464 O  O   . SER A 1 504 ? 195.874 181.405 148.253 1.00 76.89  ? 497 SER B O   1 
ATOM   3465 C  CB  . SER A 1 504 ? 195.037 184.048 148.556 1.00 73.49  ? 497 SER B CB  1 
ATOM   3466 O  OG  . SER A 1 504 ? 193.631 183.924 148.542 1.00 77.76  ? 497 SER B OG  1 
ATOM   3467 N  N   . ARG A 1 505 ? 195.704 180.968 150.452 1.00 73.57  ? 498 ARG B N   1 
ATOM   3468 C  CA  . ARG A 1 505 ? 195.976 179.547 150.313 1.00 75.29  ? 498 ARG B CA  1 
ATOM   3469 C  C   . ARG A 1 505 ? 194.896 178.736 151.008 1.00 78.84  ? 498 ARG B C   1 
ATOM   3470 O  O   . ARG A 1 505 ? 194.441 179.092 152.097 1.00 82.56  ? 498 ARG B O   1 
ATOM   3471 C  CB  . ARG A 1 505 ? 197.355 179.200 150.884 1.00 77.66  ? 498 ARG B CB  1 
ATOM   3472 C  CG  . ARG A 1 505 ? 197.397 177.936 151.717 1.00 81.89  ? 498 ARG B CG  1 
ATOM   3473 C  CD  . ARG A 1 505 ? 198.597 177.936 152.645 1.00 86.81  ? 498 ARG B CD  1 
ATOM   3474 N  NE  . ARG A 1 505 ? 198.741 179.206 153.345 1.00 99.56  ? 498 ARG B NE  1 
ATOM   3475 C  CZ  . ARG A 1 505 ? 198.040 179.554 154.415 1.00 103.31 ? 498 ARG B CZ  1 
ATOM   3476 N  NH1 . ARG A 1 505 ? 197.135 178.746 154.941 1.00 101.30 ? 498 ARG B NH1 1 
ATOM   3477 N  NH2 . ARG A 1 505 ? 198.251 180.744 154.971 1.00 103.56 ? 498 ARG B NH2 1 
ATOM   3478 N  N   . CYS A 1 506 ? 194.490 177.647 150.365 1.00 78.49  ? 499 CYS B N   1 
ATOM   3479 C  CA  . CYS A 1 506 ? 193.533 176.703 150.915 1.00 78.06  ? 499 CYS B CA  1 
ATOM   3480 C  C   . CYS A 1 506 ? 194.205 175.349 151.084 1.00 86.84  ? 499 CYS B C   1 
ATOM   3481 O  O   . CYS A 1 506 ? 195.099 174.982 150.317 1.00 90.61  ? 499 CYS B O   1 
ATOM   3482 C  CB  . CYS A 1 506 ? 192.309 176.570 150.013 1.00 79.43  ? 499 CYS B CB  1 
ATOM   3483 S  SG  . CYS A 1 506 ? 192.537 175.399 148.663 1.00 96.00  ? 499 CYS B SG  1 
ATOM   3484 N  N   . SER A 1 507 ? 193.772 174.609 152.098 1.00 87.65  ? 500 SER B N   1 
ATOM   3485 C  CA  . SER A 1 507 ? 194.374 173.325 152.425 1.00 85.01  ? 500 SER B CA  1 
ATOM   3486 C  C   . SER A 1 507 ? 193.630 172.218 151.693 1.00 87.59  ? 500 SER B C   1 
ATOM   3487 O  O   . SER A 1 507 ? 192.434 172.015 151.917 1.00 91.88  ? 500 SER B O   1 
ATOM   3488 C  CB  . SER A 1 507 ? 194.348 173.090 153.932 1.00 81.58  ? 500 SER B CB  1 
ATOM   3489 O  OG  . SER A 1 507 ? 193.040 173.254 154.446 1.00 81.90  ? 500 SER B OG  1 
ATOM   3490 N  N   . ARG A 1 508 ? 194.337 171.506 150.818 1.00 87.69  ? 501 ARG B N   1 
ATOM   3491 C  CA  . ARG A 1 508 ? 193.736 170.411 150.071 1.00 90.97  ? 501 ARG B CA  1 
ATOM   3492 C  C   . ARG A 1 508 ? 193.668 169.117 150.868 1.00 95.20  ? 501 ARG B C   1 
ATOM   3493 O  O   . ARG A 1 508 ? 192.993 168.179 150.436 1.00 95.12  ? 501 ARG B O   1 
ATOM   3494 C  CB  . ARG A 1 508 ? 194.510 170.179 148.775 1.00 90.26  ? 501 ARG B CB  1 
ATOM   3495 C  CG  . ARG A 1 508 ? 194.896 171.461 148.065 1.00 89.99  ? 501 ARG B CG  1 
ATOM   3496 C  CD  . ARG A 1 508 ? 195.468 171.184 146.690 1.00 90.82  ? 501 ARG B CD  1 
ATOM   3497 N  NE  . ARG A 1 508 ? 194.446 170.708 145.767 1.00 94.19  ? 501 ARG B NE  1 
ATOM   3498 C  CZ  . ARG A 1 508 ? 193.533 171.482 145.197 1.00 92.15  ? 501 ARG B CZ  1 
ATOM   3499 N  NH1 . ARG A 1 508 ? 193.487 172.782 145.431 1.00 93.66  ? 501 ARG B NH1 1 
ATOM   3500 N  NH2 . ARG A 1 508 ? 192.644 170.938 144.372 1.00 87.30  ? 501 ARG B NH2 1 
ATOM   3501 N  N   . GLN A 1 509 ? 194.359 169.039 152.003 1.00 97.18  ? 502 GLN B N   1 
ATOM   3502 C  CA  . GLN A 1 509 ? 194.301 167.883 152.885 1.00 96.77  ? 502 GLN B CA  1 
ATOM   3503 C  C   . GLN A 1 509 ? 194.318 168.362 154.327 1.00 95.99  ? 502 GLN B C   1 
ATOM   3504 O  O   . GLN A 1 509 ? 194.916 169.392 154.647 1.00 95.11  ? 502 GLN B O   1 
ATOM   3505 C  CB  . GLN A 1 509 ? 195.471 166.918 152.647 1.00 99.75  ? 502 GLN B CB  1 
ATOM   3506 C  CG  . GLN A 1 509 ? 195.580 166.395 151.226 1.00 98.49  ? 502 GLN B CG  1 
ATOM   3507 C  CD  . GLN A 1 509 ? 196.914 166.723 150.593 1.00 99.22  ? 502 GLN B CD  1 
ATOM   3508 O  OE1 . GLN A 1 509 ? 197.750 167.398 151.195 1.00 99.75  ? 502 GLN B OE1 1 
ATOM   3509 N  NE2 . GLN A 1 509 ? 197.122 166.249 149.372 1.00 96.41  ? 502 GLN B NE2 1 
ATOM   3510 N  N   . CYS A 1 510 ? 193.665 167.601 155.197 1.00 97.99  ? 503 CYS B N   1 
ATOM   3511 C  CA  . CYS A 1 510 ? 193.599 167.953 156.609 1.00 103.41 ? 503 CYS B CA  1 
ATOM   3512 C  C   . CYS A 1 510 ? 194.641 167.183 157.415 1.00 100.42 ? 503 CYS B C   1 
ATOM   3513 O  O   . CYS A 1 510 ? 195.006 167.581 158.522 1.00 91.27  ? 503 CYS B O   1 
ATOM   3514 C  CB  . CYS A 1 510 ? 192.201 167.684 157.161 1.00 102.43 ? 503 CYS B CB  1 
ATOM   3515 S  SG  . CYS A 1 510 ? 190.915 168.760 156.494 1.00 102.42 ? 503 CYS B SG  1 
ATOM   3516 N  N   . VAL A 1 515 ? 186.386 165.932 159.979 1.00 84.38  ? 508 VAL B N   1 
ATOM   3517 C  CA  . VAL A 1 515 ? 186.941 167.224 160.349 1.00 80.65  ? 508 VAL B CA  1 
ATOM   3518 C  C   . VAL A 1 515 ? 186.929 168.148 159.137 1.00 86.12  ? 508 VAL B C   1 
ATOM   3519 O  O   . VAL A 1 515 ? 186.806 169.363 159.274 1.00 90.55  ? 508 VAL B O   1 
ATOM   3520 C  CB  . VAL A 1 515 ? 188.361 167.069 160.932 1.00 74.23  ? 508 VAL B CB  1 
ATOM   3521 C  CG1 . VAL A 1 515 ? 189.256 166.297 159.976 1.00 70.92  ? 508 VAL B CG1 1 
ATOM   3522 C  CG2 . VAL A 1 515 ? 188.960 168.422 161.275 1.00 72.47  ? 508 VAL B CG2 1 
ATOM   3523 N  N   . ARG A 1 516 ? 187.035 167.564 157.946 1.00 85.50  ? 509 ARG B N   1 
ATOM   3524 C  CA  . ARG A 1 516 ? 187.061 168.339 156.715 1.00 87.23  ? 509 ARG B CA  1 
ATOM   3525 C  C   . ARG A 1 516 ? 185.660 168.785 156.314 1.00 87.42  ? 509 ARG B C   1 
ATOM   3526 O  O   . ARG A 1 516 ? 184.671 168.085 156.541 1.00 90.30  ? 509 ARG B O   1 
ATOM   3527 C  CB  . ARG A 1 516 ? 187.687 167.525 155.582 1.00 88.17  ? 509 ARG B CB  1 
ATOM   3528 C  CG  . ARG A 1 516 ? 186.839 166.361 155.100 1.00 88.45  ? 509 ARG B CG  1 
ATOM   3529 C  CD  . ARG A 1 516 ? 187.641 165.413 154.224 1.00 88.94  ? 509 ARG B CD  1 
ATOM   3530 N  NE  . ARG A 1 516 ? 188.572 164.607 155.004 1.00 99.51  ? 509 ARG B NE  1 
ATOM   3531 C  CZ  . ARG A 1 516 ? 189.883 164.798 155.038 1.00 105.26 ? 509 ARG B CZ  1 
ATOM   3532 N  NH1 . ARG A 1 516 ? 190.459 165.765 154.345 1.00 104.36 ? 509 ARG B NH1 1 
ATOM   3533 N  NH2 . ARG A 1 516 ? 190.636 163.999 155.788 1.00 100.29 ? 509 ARG B NH2 1 
ATOM   3534 N  N   . ARG A 1 517 ? 185.585 169.973 155.722 1.00 87.12  ? 510 ARG B N   1 
ATOM   3535 C  CA  . ARG A 1 517 ? 184.351 170.497 155.142 1.00 88.72  ? 510 ARG B CA  1 
ATOM   3536 C  C   . ARG A 1 517 ? 184.707 171.087 153.786 1.00 87.98  ? 510 ARG B C   1 
ATOM   3537 O  O   . ARG A 1 517 ? 185.423 172.089 153.716 1.00 93.26  ? 510 ARG B O   1 
ATOM   3538 C  CB  . ARG A 1 517 ? 183.710 171.551 156.044 1.00 91.67  ? 510 ARG B CB  1 
ATOM   3539 C  CG  . ARG A 1 517 ? 183.461 171.102 157.476 1.00 99.92  ? 510 ARG B CG  1 
ATOM   3540 C  CD  . ARG A 1 517 ? 182.178 170.289 157.615 1.00 111.37 ? 510 ARG B CD  1 
ATOM   3541 N  NE  . ARG A 1 517 ? 182.181 169.476 158.828 1.00 117.18 ? 510 ARG B NE  1 
ATOM   3542 C  CZ  . ARG A 1 517 ? 181.366 168.454 159.050 1.00 116.45 ? 510 ARG B CZ  1 
ATOM   3543 N  NH1 . ARG A 1 517 ? 180.445 168.100 158.169 1.00 115.76 ? 510 ARG B NH1 1 
ATOM   3544 N  NH2 . ARG A 1 517 ? 181.478 167.771 160.185 1.00 106.16 ? 510 ARG B NH2 1 
ATOM   3545 N  N   . VAL A 1 518 ? 184.207 170.473 152.712 1.00 82.96  ? 511 VAL B N   1 
ATOM   3546 C  CA  . VAL A 1 518 ? 184.616 170.866 151.369 1.00 80.44  ? 511 VAL B CA  1 
ATOM   3547 C  C   . VAL A 1 518 ? 184.185 172.296 151.091 1.00 83.40  ? 511 VAL B C   1 
ATOM   3548 O  O   . VAL A 1 518 ? 183.050 172.689 151.383 1.00 87.98  ? 511 VAL B O   1 
ATOM   3549 C  CB  . VAL A 1 518 ? 184.024 169.905 150.330 1.00 84.05  ? 511 VAL B CB  1 
ATOM   3550 C  CG1 . VAL A 1 518 ? 184.451 170.312 148.940 1.00 81.53  ? 511 VAL B CG1 1 
ATOM   3551 C  CG2 . VAL A 1 518 ? 184.438 168.482 150.628 1.00 87.76  ? 511 VAL B CG2 1 
ATOM   3552 N  N   . LYS A 1 519 ? 185.095 173.084 150.523 1.00 83.11  ? 512 LYS B N   1 
ATOM   3553 C  CA  . LYS A 1 519 ? 184.815 174.460 150.146 1.00 83.28  ? 512 LYS B CA  1 
ATOM   3554 C  C   . LYS A 1 519 ? 185.373 174.728 148.757 1.00 83.69  ? 512 LYS B C   1 
ATOM   3555 O  O   . LYS A 1 519 ? 186.306 174.061 148.308 1.00 87.72  ? 512 LYS B O   1 
ATOM   3556 C  CB  . LYS A 1 519 ? 185.408 175.450 151.150 1.00 81.21  ? 512 LYS B CB  1 
ATOM   3557 C  CG  . LYS A 1 519 ? 186.918 175.560 151.099 1.00 81.51  ? 512 LYS B CG  1 
ATOM   3558 C  CD  . LYS A 1 519 ? 187.401 176.773 151.872 1.00 82.61  ? 512 LYS B CD  1 
ATOM   3559 C  CE  . LYS A 1 519 ? 188.911 176.887 151.831 1.00 83.01  ? 512 LYS B CE  1 
ATOM   3560 N  NZ  . LYS A 1 519 ? 189.426 177.784 152.898 1.00 82.82  ? 512 LYS B NZ  1 
ATOM   3561 N  N   . GLY A 1 520 ? 184.786 175.707 148.075 1.00 82.82  ? 513 GLY B N   1 
ATOM   3562 C  CA  . GLY A 1 520 ? 185.198 176.039 146.726 1.00 81.54  ? 513 GLY B CA  1 
ATOM   3563 C  C   . GLY A 1 520 ? 184.083 175.875 145.717 1.00 81.09  ? 513 GLY B C   1 
ATOM   3564 O  O   . GLY A 1 520 ? 183.104 175.171 145.977 1.00 80.41  ? 513 GLY B O   1 
ATOM   3565 N  N   . PHE A 1 521 ? 184.208 176.530 144.562 1.00 79.77  ? 514 PHE B N   1 
ATOM   3566 C  CA  . PHE A 1 521 ? 183.174 176.419 143.538 1.00 76.91  ? 514 PHE B CA  1 
ATOM   3567 C  C   . PHE A 1 521 ? 183.198 175.051 142.874 1.00 79.36  ? 514 PHE B C   1 
ATOM   3568 O  O   . PHE A 1 521 ? 182.146 174.509 142.519 1.00 77.87  ? 514 PHE B O   1 
ATOM   3569 C  CB  . PHE A 1 521 ? 183.344 177.521 142.498 1.00 78.10  ? 514 PHE B CB  1 
ATOM   3570 C  CG  . PHE A 1 521 ? 182.125 177.755 141.658 1.00 81.14  ? 514 PHE B CG  1 
ATOM   3571 C  CD1 . PHE A 1 521 ? 180.870 177.793 142.233 1.00 81.76  ? 514 PHE B CD1 1 
ATOM   3572 C  CD2 . PHE A 1 521 ? 182.234 177.947 140.294 1.00 83.91  ? 514 PHE B CD2 1 
ATOM   3573 C  CE1 . PHE A 1 521 ? 179.746 178.014 141.463 1.00 82.74  ? 514 PHE B CE1 1 
ATOM   3574 C  CE2 . PHE A 1 521 ? 181.113 178.169 139.521 1.00 82.85  ? 514 PHE B CE2 1 
ATOM   3575 C  CZ  . PHE A 1 521 ? 179.869 178.202 140.106 1.00 80.50  ? 514 PHE B CZ  1 
ATOM   3576 N  N   . HIS A 1 522 ? 184.385 174.483 142.684 1.00 82.63  ? 515 HIS B N   1 
ATOM   3577 C  CA  . HIS A 1 522 ? 184.535 173.172 142.071 1.00 80.19  ? 515 HIS B CA  1 
ATOM   3578 C  C   . HIS A 1 522 ? 184.833 172.081 143.090 1.00 78.86  ? 515 HIS B C   1 
ATOM   3579 O  O   . HIS A 1 522 ? 185.195 170.968 142.699 1.00 77.39  ? 515 HIS B O   1 
ATOM   3580 C  CB  . HIS A 1 522 ? 185.634 173.211 141.009 1.00 83.58  ? 515 HIS B CB  1 
ATOM   3581 C  CG  . HIS A 1 522 ? 185.250 173.955 139.769 1.00 85.73  ? 515 HIS B CG  1 
ATOM   3582 N  ND1 . HIS A 1 522 ? 184.411 175.048 139.786 1.00 85.66  ? 515 HIS B ND1 1 
ATOM   3583 C  CD2 . HIS A 1 522 ? 185.592 173.764 138.474 1.00 89.25  ? 515 HIS B CD2 1 
ATOM   3584 C  CE1 . HIS A 1 522 ? 184.253 175.498 138.554 1.00 85.66  ? 515 HIS B CE1 1 
ATOM   3585 N  NE2 . HIS A 1 522 ? 184.957 174.735 137.739 1.00 88.89  ? 515 HIS B NE2 1 
ATOM   3586 N  N   . SER A 1 523 ? 184.694 172.378 144.382 1.00 80.81  ? 516 SER B N   1 
ATOM   3587 C  CA  . SER A 1 523 ? 184.891 171.409 145.459 1.00 82.69  ? 516 SER B CA  1 
ATOM   3588 C  C   . SER A 1 523 ? 186.306 170.830 145.439 1.00 84.70  ? 516 SER B C   1 
ATOM   3589 O  O   . SER A 1 523 ? 186.521 169.644 145.195 1.00 86.97  ? 516 SER B O   1 
ATOM   3590 C  CB  . SER A 1 523 ? 183.839 170.301 145.393 1.00 79.89  ? 516 SER B CB  1 
ATOM   3591 O  OG  . SER A 1 523 ? 182.659 170.688 146.069 1.00 79.43  ? 516 SER B OG  1 
ATOM   3592 N  N   . CYS A 1 524 ? 187.279 171.701 145.700 1.00 84.52  ? 517 CYS B N   1 
ATOM   3593 C  CA  . CYS A 1 524 ? 188.684 171.320 145.727 1.00 86.48  ? 517 CYS B CA  1 
ATOM   3594 C  C   . CYS A 1 524 ? 189.253 171.293 147.134 1.00 87.00  ? 517 CYS B C   1 
ATOM   3595 O  O   . CYS A 1 524 ? 189.849 170.297 147.550 1.00 91.44  ? 517 CYS B O   1 
ATOM   3596 C  CB  . CYS A 1 524 ? 189.512 172.309 144.912 1.00 92.03  ? 517 CYS B CB  1 
ATOM   3597 S  SG  . CYS A 1 524 ? 188.990 172.562 143.243 1.00 107.88 ? 517 CYS B SG  1 
ATOM   3598 N  N   . CYS A 1 525 ? 189.087 172.386 147.870 1.00 84.91  ? 518 CYS B N   1 
ATOM   3599 C  CA  . CYS A 1 525 ? 189.785 172.612 149.119 1.00 84.57  ? 518 CYS B CA  1 
ATOM   3600 C  C   . CYS A 1 525 ? 189.056 171.932 150.270 1.00 86.10  ? 518 CYS B C   1 
ATOM   3601 O  O   . CYS A 1 525 ? 188.089 171.192 150.083 1.00 88.83  ? 518 CYS B O   1 
ATOM   3602 C  CB  . CYS A 1 525 ? 189.920 174.109 149.374 1.00 85.97  ? 518 CYS B CB  1 
ATOM   3603 S  SG  . CYS A 1 525 ? 190.658 175.008 148.011 1.00 107.82 ? 518 CYS B SG  1 
ATOM   3604 N  N   . TYR A 1 526 ? 189.534 172.184 151.484 1.00 85.12  ? 519 TYR B N   1 
ATOM   3605 C  CA  . TYR A 1 526 ? 188.910 171.642 152.679 1.00 85.66  ? 519 TYR B CA  1 
ATOM   3606 C  C   . TYR A 1 526 ? 189.094 172.628 153.819 1.00 84.52  ? 519 TYR B C   1 
ATOM   3607 O  O   . TYR A 1 526 ? 190.212 173.077 154.079 1.00 84.80  ? 519 TYR B O   1 
ATOM   3608 C  CB  . TYR A 1 526 ? 189.507 170.283 153.045 1.00 87.63  ? 519 TYR B CB  1 
ATOM   3609 C  CG  . TYR A 1 526 ? 189.177 169.190 152.063 1.00 87.08  ? 519 TYR B CG  1 
ATOM   3610 C  CD1 . TYR A 1 526 ? 187.989 168.489 152.153 1.00 87.22  ? 519 TYR B CD1 1 
ATOM   3611 C  CD2 . TYR A 1 526 ? 190.053 168.861 151.045 1.00 89.49  ? 519 TYR B CD2 1 
ATOM   3612 C  CE1 . TYR A 1 526 ? 187.686 167.489 151.260 1.00 91.68  ? 519 TYR B CE1 1 
ATOM   3613 C  CE2 . TYR A 1 526 ? 189.757 167.863 150.145 1.00 91.11  ? 519 TYR B CE2 1 
ATOM   3614 C  CZ  . TYR A 1 526 ? 188.571 167.181 150.257 1.00 94.64  ? 519 TYR B CZ  1 
ATOM   3615 O  OH  . TYR A 1 526 ? 188.268 166.184 149.363 1.00 99.22  ? 519 TYR B OH  1 
ATOM   3616 N  N   . ASP A 1 527 ? 187.996 172.957 154.492 1.00 85.03  ? 520 ASP B N   1 
ATOM   3617 C  CA  . ASP A 1 527 ? 188.025 173.862 155.638 1.00 85.92  ? 520 ASP B CA  1 
ATOM   3618 C  C   . ASP A 1 527 ? 188.373 173.066 156.896 1.00 91.25  ? 520 ASP B C   1 
ATOM   3619 O  O   . ASP A 1 527 ? 187.546 172.830 157.777 1.00 94.52  ? 520 ASP B O   1 
ATOM   3620 C  CB  . ASP A 1 527 ? 186.688 174.574 155.778 1.00 86.93  ? 520 ASP B CB  1 
ATOM   3621 C  CG  . ASP A 1 527 ? 186.838 176.069 155.938 1.00 91.54  ? 520 ASP B CG  1 
ATOM   3622 O  OD1 . ASP A 1 527 ? 187.934 176.517 156.332 1.00 92.28  ? 520 ASP B OD1 1 
ATOM   3623 O  OD2 . ASP A 1 527 ? 185.859 176.798 155.672 1.00 92.75  ? 520 ASP B OD2 1 
ATOM   3624 N  N   . CYS A 1 528 ? 189.632 172.649 156.964 1.00 88.25  ? 521 CYS B N   1 
ATOM   3625 C  CA  . CYS A 1 528 ? 190.104 171.847 158.086 1.00 86.27  ? 521 CYS B CA  1 
ATOM   3626 C  C   . CYS A 1 528 ? 190.010 172.622 159.396 1.00 89.92  ? 521 CYS B C   1 
ATOM   3627 O  O   . CYS A 1 528 ? 189.168 172.326 160.243 1.00 87.54  ? 521 CYS B O   1 
ATOM   3628 C  CB  . CYS A 1 528 ? 191.543 171.390 157.855 1.00 88.58  ? 521 CYS B CB  1 
ATOM   3629 S  SG  . CYS A 1 528 ? 191.825 170.560 156.281 1.00 102.72 ? 521 CYS B SG  1 
ATOM   3630 N  N   . SER B 2 34  ? 162.340 161.474 96.095  1.00 102.25 ? 25  SER A N   1 
ATOM   3631 C  CA  . SER B 2 34  ? 162.414 160.812 97.391  1.00 104.56 ? 25  SER A CA  1 
ATOM   3632 C  C   . SER B 2 34  ? 161.547 161.533 98.413  1.00 98.61  ? 25  SER A C   1 
ATOM   3633 O  O   . SER B 2 34  ? 160.600 162.229 98.054  1.00 97.18  ? 25  SER A O   1 
ATOM   3634 C  CB  . SER B 2 34  ? 163.862 160.746 97.880  1.00 99.87  ? 25  SER A CB  1 
ATOM   3635 O  OG  . SER B 2 34  ? 164.066 159.628 98.723  1.00 93.30  ? 25  SER A OG  1 
ATOM   3636 N  N   . ASP B 2 35  ? 161.874 161.360 99.689  1.00 94.26  ? 26  ASP A N   1 
ATOM   3637 C  CA  . ASP B 2 35  ? 161.178 162.048 100.765 1.00 94.03  ? 26  ASP A CA  1 
ATOM   3638 C  C   . ASP B 2 35  ? 161.885 163.323 101.202 1.00 89.92  ? 26  ASP A C   1 
ATOM   3639 O  O   . ASP B 2 35  ? 161.463 163.942 102.183 1.00 91.16  ? 26  ASP A O   1 
ATOM   3640 C  CB  . ASP B 2 35  ? 160.996 161.116 101.968 1.00 101.68 ? 26  ASP A CB  1 
ATOM   3641 C  CG  . ASP B 2 35  ? 162.189 160.207 102.194 1.00 104.05 ? 26  ASP A CG  1 
ATOM   3642 O  OD1 . ASP B 2 35  ? 163.334 160.652 101.977 1.00 102.97 ? 26  ASP A OD1 1 
ATOM   3643 O  OD2 . ASP B 2 35  ? 161.979 159.041 102.593 1.00 101.33 ? 26  ASP A OD2 1 
ATOM   3644 N  N   . PHE B 2 36  ? 162.948 163.721 100.512 1.00 84.31  ? 27  PHE A N   1 
ATOM   3645 C  CA  . PHE B 2 36  ? 163.628 164.979 100.773 1.00 77.62  ? 27  PHE A CA  1 
ATOM   3646 C  C   . PHE B 2 36  ? 163.190 166.093 99.837  1.00 78.91  ? 27  PHE A C   1 
ATOM   3647 O  O   . PHE B 2 36  ? 163.772 167.179 99.880  1.00 82.12  ? 27  PHE A O   1 
ATOM   3648 C  CB  . PHE B 2 36  ? 165.141 164.801 100.653 1.00 80.19  ? 27  PHE A CB  1 
ATOM   3649 C  CG  . PHE B 2 36  ? 165.754 163.996 101.757 1.00 85.25  ? 27  PHE A CG  1 
ATOM   3650 C  CD1 . PHE B 2 36  ? 165.680 162.618 101.750 1.00 92.94  ? 27  PHE A CD1 1 
ATOM   3651 C  CD2 . PHE B 2 36  ? 166.437 164.616 102.784 1.00 84.72  ? 27  PHE A CD2 1 
ATOM   3652 C  CE1 . PHE B 2 36  ? 166.257 161.877 102.757 1.00 95.27  ? 27  PHE A CE1 1 
ATOM   3653 C  CE2 . PHE B 2 36  ? 167.016 163.881 103.792 1.00 87.24  ? 27  PHE A CE2 1 
ATOM   3654 C  CZ  . PHE B 2 36  ? 166.926 162.511 103.779 1.00 92.54  ? 27  PHE A CZ  1 
ATOM   3655 N  N   . TYR B 2 37  ? 162.199 165.854 98.983  1.00 80.66  ? 28  TYR A N   1 
ATOM   3656 C  CA  . TYR B 2 37  ? 161.845 166.823 97.955  1.00 80.37  ? 28  TYR A CA  1 
ATOM   3657 C  C   . TYR B 2 37  ? 160.403 166.583 97.538  1.00 84.51  ? 28  TYR A C   1 
ATOM   3658 O  O   . TYR B 2 37  ? 160.035 165.456 97.197  1.00 89.28  ? 28  TYR A O   1 
ATOM   3659 C  CB  . TYR B 2 37  ? 162.786 166.690 96.751  1.00 83.99  ? 28  TYR A CB  1 
ATOM   3660 C  CG  . TYR B 2 37  ? 162.589 167.703 95.640  1.00 91.88  ? 28  TYR A CG  1 
ATOM   3661 C  CD1 . TYR B 2 37  ? 163.232 167.545 94.419  1.00 94.35  ? 28  TYR A CD1 1 
ATOM   3662 C  CD2 . TYR B 2 37  ? 161.806 168.836 95.821  1.00 89.53  ? 28  TYR A CD2 1 
ATOM   3663 C  CE1 . TYR B 2 37  ? 163.071 168.463 93.401  1.00 97.96  ? 28  TYR A CE1 1 
ATOM   3664 C  CE2 . TYR B 2 37  ? 161.640 169.760 94.809  1.00 92.41  ? 28  TYR A CE2 1 
ATOM   3665 C  CZ  . TYR B 2 37  ? 162.276 169.569 93.603  1.00 99.76  ? 28  TYR A CZ  1 
ATOM   3666 O  OH  . TYR B 2 37  ? 162.117 170.488 92.593  1.00 103.14 ? 28  TYR A OH  1 
ATOM   3667 N  N   . LEU B 2 38  ? 159.596 167.636 97.571  1.00 81.86  ? 29  LEU A N   1 
ATOM   3668 C  CA  . LEU B 2 38  ? 158.236 167.586 97.054  1.00 83.39  ? 29  LEU A CA  1 
ATOM   3669 C  C   . LEU B 2 38  ? 157.935 168.885 96.320  1.00 82.25  ? 29  LEU A C   1 
ATOM   3670 O  O   . LEU B 2 38  ? 157.726 169.922 96.959  1.00 79.42  ? 29  LEU A O   1 
ATOM   3671 C  CB  . LEU B 2 38  ? 157.229 167.360 98.181  1.00 80.93  ? 29  LEU A CB  1 
ATOM   3672 C  CG  . LEU B 2 38  ? 155.767 167.307 97.743  1.00 80.51  ? 29  LEU A CG  1 
ATOM   3673 C  CD1 . LEU B 2 38  ? 155.388 165.898 97.312  1.00 80.79  ? 29  LEU A CD1 1 
ATOM   3674 C  CD2 . LEU B 2 38  ? 154.853 167.800 98.850  1.00 78.09  ? 29  LEU A CD2 1 
ATOM   3675 N  N   . PRO B 2 39  ? 157.913 168.875 94.992  1.00 84.47  ? 30  PRO A N   1 
ATOM   3676 C  CA  . PRO B 2 39  ? 157.708 170.122 94.250  1.00 83.58  ? 30  PRO A CA  1 
ATOM   3677 C  C   . PRO B 2 39  ? 156.328 170.706 94.491  1.00 81.74  ? 30  PRO A C   1 
ATOM   3678 O  O   . PRO B 2 39  ? 155.355 169.990 94.739  1.00 83.57  ? 30  PRO A O   1 
ATOM   3679 C  CB  . PRO B 2 39  ? 157.881 169.697 92.789  1.00 83.43  ? 30  PRO A CB  1 
ATOM   3680 C  CG  . PRO B 2 39  ? 157.576 168.242 92.785  1.00 83.01  ? 30  PRO A CG  1 
ATOM   3681 C  CD  . PRO B 2 39  ? 158.064 167.717 94.098  1.00 84.31  ? 30  PRO A CD  1 
ATOM   3682 N  N   . GLY B 2 40  ? 156.255 172.030 94.411  1.00 75.43  ? 31  GLY A N   1 
ATOM   3683 C  CA  . GLY B 2 40  ? 155.007 172.734 94.629  1.00 73.92  ? 31  GLY A CA  1 
ATOM   3684 C  C   . GLY B 2 40  ? 155.150 174.184 94.229  1.00 78.21  ? 31  GLY A C   1 
ATOM   3685 O  O   . GLY B 2 40  ? 156.210 174.629 93.783  1.00 82.73  ? 31  GLY A O   1 
ATOM   3686 N  N   . ASP B 2 41  ? 154.050 174.924 94.389  1.00 80.67  ? 32  ASP A N   1 
ATOM   3687 C  CA  . ASP B 2 41  ? 154.055 176.338 94.029  1.00 80.13  ? 32  ASP A CA  1 
ATOM   3688 C  C   . ASP B 2 41  ? 155.049 177.123 94.872  1.00 78.07  ? 32  ASP A C   1 
ATOM   3689 O  O   . ASP B 2 41  ? 155.811 177.940 94.345  1.00 79.60  ? 32  ASP A O   1 
ATOM   3690 C  CB  . ASP B 2 41  ? 152.652 176.923 94.180  1.00 82.61  ? 32  ASP A CB  1 
ATOM   3691 C  CG  . ASP B 2 41  ? 151.796 176.709 92.951  1.00 93.40  ? 32  ASP A CG  1 
ATOM   3692 O  OD1 . ASP B 2 41  ? 152.163 177.223 91.875  1.00 102.39 ? 32  ASP A OD1 1 
ATOM   3693 O  OD2 . ASP B 2 41  ? 150.755 176.030 93.059  1.00 92.74  ? 32  ASP A OD2 1 
ATOM   3694 N  N   . TYR B 2 42  ? 155.059 176.890 96.181  1.00 74.56  ? 33  TYR A N   1 
ATOM   3695 C  CA  . TYR B 2 42  ? 155.961 177.575 97.094  1.00 71.96  ? 33  TYR A CA  1 
ATOM   3696 C  C   . TYR B 2 42  ? 156.741 176.540 97.883  1.00 72.39  ? 33  TYR A C   1 
ATOM   3697 O  O   . TYR B 2 42  ? 156.155 175.601 98.428  1.00 74.07  ? 33  TYR A O   1 
ATOM   3698 C  CB  . TYR B 2 42  ? 155.196 178.501 98.041  1.00 69.99  ? 33  TYR A CB  1 
ATOM   3699 C  CG  . TYR B 2 42  ? 154.357 179.529 97.326  1.00 72.36  ? 33  TYR A CG  1 
ATOM   3700 C  CD1 . TYR B 2 42  ? 154.895 180.746 96.947  1.00 74.16  ? 33  TYR A CD1 1 
ATOM   3701 C  CD2 . TYR B 2 42  ? 153.031 179.279 97.023  1.00 75.45  ? 33  TYR A CD2 1 
ATOM   3702 C  CE1 . TYR B 2 42  ? 154.136 181.685 96.290  1.00 76.29  ? 33  TYR A CE1 1 
ATOM   3703 C  CE2 . TYR B 2 42  ? 152.263 180.211 96.366  1.00 75.86  ? 33  TYR A CE2 1 
ATOM   3704 C  CZ  . TYR B 2 42  ? 152.820 181.412 96.002  1.00 77.06  ? 33  TYR A CZ  1 
ATOM   3705 O  OH  . TYR B 2 42  ? 152.058 182.347 95.345  1.00 83.93  ? 33  TYR A OH  1 
ATOM   3706 N  N   . LEU B 2 43  ? 158.054 176.707 97.940  1.00 69.86  ? 34  LEU A N   1 
ATOM   3707 C  CA  . LEU B 2 43  ? 158.902 175.758 98.637  1.00 67.04  ? 34  LEU A CA  1 
ATOM   3708 C  C   . LEU B 2 43  ? 158.993 176.109 100.118 1.00 65.67  ? 34  LEU A C   1 
ATOM   3709 O  O   . LEU B 2 43  ? 158.555 177.169 100.565 1.00 64.07  ? 34  LEU A O   1 
ATOM   3710 C  CB  . LEU B 2 43  ? 160.289 175.716 97.999  1.00 68.11  ? 34  LEU A CB  1 
ATOM   3711 C  CG  . LEU B 2 43  ? 160.348 175.119 96.595  1.00 65.15  ? 34  LEU A CG  1 
ATOM   3712 C  CD1 . LEU B 2 43  ? 161.731 174.581 96.311  1.00 67.37  ? 34  LEU A CD1 1 
ATOM   3713 C  CD2 . LEU B 2 43  ? 159.313 174.024 96.432  1.00 70.51  ? 34  LEU A CD2 1 
ATOM   3714 N  N   . LEU B 2 44  ? 159.574 175.188 100.887 1.00 63.36  ? 35  LEU A N   1 
ATOM   3715 C  CA  . LEU B 2 44  ? 159.654 175.335 102.338 1.00 57.22  ? 35  LEU A CA  1 
ATOM   3716 C  C   . LEU B 2 44  ? 160.903 174.598 102.807 1.00 58.69  ? 35  LEU A C   1 
ATOM   3717 O  O   . LEU B 2 44  ? 160.865 173.382 103.004 1.00 63.91  ? 35  LEU A O   1 
ATOM   3718 C  CB  . LEU B 2 44  ? 158.404 174.782 103.002 1.00 58.27  ? 35  LEU A CB  1 
ATOM   3719 C  CG  . LEU B 2 44  ? 157.965 175.476 104.278 1.00 54.78  ? 35  LEU A CG  1 
ATOM   3720 C  CD1 . LEU B 2 44  ? 157.188 176.691 103.881 1.00 53.85  ? 35  LEU A CD1 1 
ATOM   3721 C  CD2 . LEU B 2 44  ? 157.115 174.548 105.107 1.00 56.10  ? 35  LEU A CD2 1 
ATOM   3722 N  N   . GLY B 2 45  ? 161.995 175.333 102.988 1.00 55.76  ? 36  GLY A N   1 
ATOM   3723 C  CA  . GLY B 2 45  ? 163.235 174.693 103.388 1.00 57.00  ? 36  GLY A CA  1 
ATOM   3724 C  C   . GLY B 2 45  ? 163.106 174.031 104.747 1.00 55.91  ? 36  GLY A C   1 
ATOM   3725 O  O   . GLY B 2 45  ? 162.406 174.518 105.635 1.00 56.94  ? 36  GLY A O   1 
ATOM   3726 N  N   . GLY B 2 46  ? 163.782 172.900 104.904 1.00 57.46  ? 37  GLY A N   1 
ATOM   3727 C  CA  . GLY B 2 46  ? 163.774 172.202 106.171 1.00 58.01  ? 37  GLY A CA  1 
ATOM   3728 C  C   . GLY B 2 46  ? 165.142 171.693 106.567 1.00 61.99  ? 37  GLY A C   1 
ATOM   3729 O  O   . GLY B 2 46  ? 165.747 170.902 105.842 1.00 68.28  ? 37  GLY A O   1 
ATOM   3730 N  N   . LEU B 2 47  ? 165.638 172.131 107.716 1.00 55.89  ? 38  LEU A N   1 
ATOM   3731 C  CA  . LEU B 2 47  ? 166.943 171.727 108.217 1.00 56.62  ? 38  LEU A CA  1 
ATOM   3732 C  C   . LEU B 2 47  ? 166.733 170.795 109.401 1.00 63.19  ? 38  LEU A C   1 
ATOM   3733 O  O   . LEU B 2 47  ? 166.090 171.175 110.383 1.00 70.18  ? 38  LEU A O   1 
ATOM   3734 C  CB  . LEU B 2 47  ? 167.767 172.945 108.628 1.00 58.26  ? 38  LEU A CB  1 
ATOM   3735 C  CG  . LEU B 2 47  ? 168.022 173.981 107.536 1.00 56.72  ? 38  LEU A CG  1 
ATOM   3736 C  CD1 . LEU B 2 47  ? 168.683 175.215 108.105 1.00 58.23  ? 38  LEU A CD1 1 
ATOM   3737 C  CD2 . LEU B 2 47  ? 168.883 173.389 106.465 1.00 58.92  ? 38  LEU A CD2 1 
ATOM   3738 N  N   . PHE B 2 48  ? 167.265 169.581 109.305 1.00 64.44  ? 39  PHE A N   1 
ATOM   3739 C  CA  . PHE B 2 48  ? 167.093 168.579 110.345 1.00 67.25  ? 39  PHE A CA  1 
ATOM   3740 C  C   . PHE B 2 48  ? 168.413 167.868 110.584 1.00 74.81  ? 39  PHE A C   1 
ATOM   3741 O  O   . PHE B 2 48  ? 169.216 167.698 109.665 1.00 80.58  ? 39  PHE A O   1 
ATOM   3742 C  CB  . PHE B 2 48  ? 166.016 167.559 109.973 1.00 66.16  ? 39  PHE A CB  1 
ATOM   3743 C  CG  . PHE B 2 48  ? 164.648 168.148 109.841 1.00 63.28  ? 39  PHE A CG  1 
ATOM   3744 C  CD1 . PHE B 2 48  ? 164.252 168.755 108.668 1.00 63.62  ? 39  PHE A CD1 1 
ATOM   3745 C  CD2 . PHE B 2 48  ? 163.753 168.089 110.887 1.00 62.56  ? 39  PHE A CD2 1 
ATOM   3746 C  CE1 . PHE B 2 48  ? 162.994 169.296 108.548 1.00 63.56  ? 39  PHE A CE1 1 
ATOM   3747 C  CE2 . PHE B 2 48  ? 162.496 168.628 110.768 1.00 62.12  ? 39  PHE A CE2 1 
ATOM   3748 C  CZ  . PHE B 2 48  ? 162.116 169.231 109.598 1.00 61.56  ? 39  PHE A CZ  1 
ATOM   3749 N  N   . SER B 2 49  ? 168.627 167.443 111.826 1.00 75.74  ? 40  SER A N   1 
ATOM   3750 C  CA  . SER B 2 49  ? 169.859 166.756 112.209 1.00 80.82  ? 40  SER A CA  1 
ATOM   3751 C  C   . SER B 2 49  ? 169.652 165.262 112.022 1.00 84.39  ? 40  SER A C   1 
ATOM   3752 O  O   . SER B 2 49  ? 169.226 164.554 112.931 1.00 90.08  ? 40  SER A O   1 
ATOM   3753 C  CB  . SER B 2 49  ? 170.240 167.088 113.644 1.00 89.03  ? 40  SER A CB  1 
ATOM   3754 O  OG  . SER B 2 49  ? 169.129 166.933 114.506 1.00 93.21  ? 40  SER A OG  1 
ATOM   3755 N  N   . LEU B 2 50  ? 169.963 164.773 110.823 1.00 84.90  ? 41  LEU A N   1 
ATOM   3756 C  CA  . LEU B 2 50  ? 169.807 163.354 110.536 1.00 87.64  ? 41  LEU A CA  1 
ATOM   3757 C  C   . LEU B 2 50  ? 170.962 162.511 111.052 1.00 93.26  ? 41  LEU A C   1 
ATOM   3758 O  O   . LEU B 2 50  ? 170.830 161.286 111.123 1.00 94.83  ? 41  LEU A O   1 
ATOM   3759 C  CB  . LEU B 2 50  ? 169.660 163.132 109.033 1.00 89.88  ? 41  LEU A CB  1 
ATOM   3760 C  CG  . LEU B 2 50  ? 168.288 163.434 108.450 1.00 85.41  ? 41  LEU A CG  1 
ATOM   3761 C  CD1 . LEU B 2 50  ? 168.184 162.846 107.064 1.00 89.83  ? 41  LEU A CD1 1 
ATOM   3762 C  CD2 . LEU B 2 50  ? 167.228 162.861 109.352 1.00 81.55  ? 41  LEU A CD2 1 
ATOM   3763 N  N   . HIS B 2 51  ? 172.086 163.128 111.405 1.00 93.31  ? 42  HIS A N   1 
ATOM   3764 C  CA  . HIS B 2 51  ? 173.251 162.387 111.859 1.00 93.09  ? 42  HIS A CA  1 
ATOM   3765 C  C   . HIS B 2 51  ? 173.988 163.213 112.898 1.00 94.81  ? 42  HIS A C   1 
ATOM   3766 O  O   . HIS B 2 51  ? 173.854 164.436 112.958 1.00 94.81  ? 42  HIS A O   1 
ATOM   3767 C  CB  . HIS B 2 51  ? 174.190 162.042 110.699 1.00 97.82  ? 42  HIS A CB  1 
ATOM   3768 C  CG  . HIS B 2 51  ? 173.570 161.170 109.654 1.00 99.02  ? 42  HIS A CG  1 
ATOM   3769 N  ND1 . HIS B 2 51  ? 172.909 161.679 108.558 1.00 98.67  ? 42  HIS A ND1 1 
ATOM   3770 C  CD2 . HIS B 2 51  ? 173.526 159.824 109.527 1.00 101.12 ? 42  HIS A CD2 1 
ATOM   3771 C  CE1 . HIS B 2 51  ? 172.476 160.684 107.806 1.00 98.85  ? 42  HIS A CE1 1 
ATOM   3772 N  NE2 . HIS B 2 51  ? 172.837 159.547 108.371 1.00 99.22  ? 42  HIS A NE2 1 
ATOM   3773 N  N   . ALA B 2 52  ? 174.776 162.526 113.718 1.00 100.10 ? 43  ALA A N   1 
ATOM   3774 C  CA  . ALA B 2 52  ? 175.578 163.178 114.738 1.00 103.35 ? 43  ALA A CA  1 
ATOM   3775 C  C   . ALA B 2 52  ? 176.940 162.505 114.803 1.00 108.44 ? 43  ALA A C   1 
ATOM   3776 O  O   . ALA B 2 52  ? 177.119 161.373 114.350 1.00 109.67 ? 43  ALA A O   1 
ATOM   3777 C  CB  . ALA B 2 52  ? 174.895 163.137 116.108 1.00 105.49 ? 43  ALA A CB  1 
ATOM   3778 N  N   . ASN B 2 53  ? 177.904 163.220 115.379 1.00 106.93 ? 44  ASN A N   1 
ATOM   3779 C  CA  . ASN B 2 53  ? 179.283 162.742 115.458 1.00 110.75 ? 44  ASN A CA  1 
ATOM   3780 C  C   . ASN B 2 53  ? 179.411 161.776 116.633 1.00 116.07 ? 44  ASN A C   1 
ATOM   3781 O  O   . ASN B 2 53  ? 179.861 162.124 117.727 1.00 117.67 ? 44  ASN A O   1 
ATOM   3782 C  CB  . ASN B 2 53  ? 180.245 163.916 115.582 1.00 112.15 ? 44  ASN A CB  1 
ATOM   3783 C  CG  . ASN B 2 53  ? 181.624 163.596 115.051 1.00 111.11 ? 44  ASN A CG  1 
ATOM   3784 O  OD1 . ASN B 2 53  ? 181.895 162.469 114.636 1.00 109.36 ? 44  ASN A OD1 1 
ATOM   3785 N  ND2 . ASN B 2 53  ? 182.505 164.590 115.052 1.00 108.75 ? 44  ASN A ND2 1 
ATOM   3786 N  N   . MET B 2 54  ? 179.005 160.530 116.394 1.00 116.33 ? 45  MET A N   1 
ATOM   3787 C  CA  . MET B 2 54  ? 179.143 159.463 117.376 1.00 115.07 ? 45  MET A CA  1 
ATOM   3788 C  C   . MET B 2 54  ? 180.360 158.586 117.116 1.00 116.24 ? 45  MET A C   1 
ATOM   3789 O  O   . MET B 2 54  ? 180.479 157.516 117.720 1.00 115.72 ? 45  MET A O   1 
ATOM   3790 C  CB  . MET B 2 54  ? 177.879 158.603 117.423 1.00 112.33 ? 45  MET A CB  1 
ATOM   3791 C  CG  . MET B 2 54  ? 176.579 159.380 117.290 1.00 113.13 ? 45  MET A CG  1 
ATOM   3792 S  SD  . MET B 2 54  ? 175.141 158.296 117.224 1.00 114.83 ? 45  MET A SD  1 
ATOM   3793 C  CE  . MET B 2 54  ? 173.840 159.405 117.744 1.00 96.85  ? 45  MET A CE  1 
ATOM   3794 N  N   . LYS B 2 55  ? 181.256 159.015 116.230 1.00 119.62 ? 46  LYS A N   1 
ATOM   3795 C  CA  . LYS B 2 55  ? 182.517 158.327 115.955 1.00 120.45 ? 46  LYS A CA  1 
ATOM   3796 C  C   . LYS B 2 55  ? 182.313 156.853 115.611 1.00 121.26 ? 46  LYS A C   1 
ATOM   3797 O  O   . LYS B 2 55  ? 181.290 156.476 115.040 1.00 121.21 ? 46  LYS A O   1 
ATOM   3798 C  CB  . LYS B 2 55  ? 183.471 158.460 117.147 1.00 119.10 ? 46  LYS A CB  1 
ATOM   3799 C  CG  . LYS B 2 55  ? 183.393 159.798 117.870 1.00 115.69 ? 46  LYS A CG  1 
ATOM   3800 C  CD  . LYS B 2 55  ? 183.959 160.930 117.033 1.00 111.01 ? 46  LYS A CD  1 
ATOM   3801 C  CE  . LYS B 2 55  ? 185.392 160.650 116.624 1.00 108.26 ? 46  LYS A CE  1 
ATOM   3802 N  NZ  . LYS B 2 55  ? 185.835 161.540 115.517 1.00 96.81  ? 46  LYS A NZ  1 
ATOM   3803 N  N   . ASN B 2 61  ? 191.997 165.438 108.559 1.00 119.99 ? 52  ASN A N   1 
ATOM   3804 C  CA  . ASN B 2 61  ? 192.356 166.088 107.304 1.00 120.72 ? 52  ASN A CA  1 
ATOM   3805 C  C   . ASN B 2 61  ? 191.249 167.032 106.852 1.00 120.33 ? 52  ASN A C   1 
ATOM   3806 O  O   . ASN B 2 61  ? 190.098 166.626 106.708 1.00 123.30 ? 52  ASN A O   1 
ATOM   3807 C  CB  . ASN B 2 61  ? 192.635 165.046 106.221 1.00 119.90 ? 52  ASN A CB  1 
ATOM   3808 C  CG  . ASN B 2 61  ? 193.468 165.599 105.087 1.00 119.19 ? 52  ASN A CG  1 
ATOM   3809 O  OD1 . ASN B 2 61  ? 194.562 166.119 105.304 1.00 120.42 ? 52  ASN A OD1 1 
ATOM   3810 N  ND2 . ASN B 2 61  ? 192.955 165.492 103.868 1.00 116.20 ? 52  ASN A ND2 1 
ATOM   3811 N  N   . PHE B 2 62  ? 191.601 168.296 106.628 1.00 115.91 ? 53  PHE A N   1 
ATOM   3812 C  CA  . PHE B 2 62  ? 190.620 169.305 106.259 1.00 114.73 ? 53  PHE A CA  1 
ATOM   3813 C  C   . PHE B 2 62  ? 190.432 169.446 104.755 1.00 118.64 ? 53  PHE A C   1 
ATOM   3814 O  O   . PHE B 2 62  ? 189.502 170.139 104.331 1.00 118.36 ? 53  PHE A O   1 
ATOM   3815 C  CB  . PHE B 2 62  ? 191.013 170.664 106.848 1.00 107.03 ? 53  PHE A CB  1 
ATOM   3816 C  CG  . PHE B 2 62  ? 192.438 171.052 106.580 1.00 108.24 ? 53  PHE A CG  1 
ATOM   3817 C  CD1 . PHE B 2 62  ? 192.802 171.626 105.376 1.00 105.25 ? 53  PHE A CD1 1 
ATOM   3818 C  CD2 . PHE B 2 62  ? 193.417 170.837 107.533 1.00 108.95 ? 53  PHE A CD2 1 
ATOM   3819 C  CE1 . PHE B 2 62  ? 194.113 171.980 105.132 1.00 105.27 ? 53  PHE A CE1 1 
ATOM   3820 C  CE2 . PHE B 2 62  ? 194.730 171.188 107.291 1.00 106.50 ? 53  PHE A CE2 1 
ATOM   3821 C  CZ  . PHE B 2 62  ? 195.077 171.760 106.090 1.00 105.56 ? 53  PHE A CZ  1 
ATOM   3822 N  N   . LEU B 2 63  ? 191.285 168.818 103.941 1.00 119.35 ? 54  LEU A N   1 
ATOM   3823 C  CA  . LEU B 2 63  ? 191.121 168.915 102.492 1.00 116.42 ? 54  LEU A CA  1 
ATOM   3824 C  C   . LEU B 2 63  ? 189.843 168.228 102.029 1.00 116.15 ? 54  LEU A C   1 
ATOM   3825 O  O   . LEU B 2 63  ? 189.091 168.784 101.222 1.00 112.07 ? 54  LEU A O   1 
ATOM   3826 C  CB  . LEU B 2 63  ? 192.338 168.328 101.778 1.00 114.84 ? 54  LEU A CB  1 
ATOM   3827 C  CG  . LEU B 2 63  ? 193.675 169.053 101.955 1.00 114.50 ? 54  LEU A CG  1 
ATOM   3828 C  CD1 . LEU B 2 63  ? 193.456 170.554 102.035 1.00 104.48 ? 54  LEU A CD1 1 
ATOM   3829 C  CD2 . LEU B 2 63  ? 194.429 168.547 103.175 1.00 115.33 ? 54  LEU A CD2 1 
ATOM   3830 N  N   . GLN B 2 64  ? 189.577 167.026 102.523 1.00 119.26 ? 55  GLN A N   1 
ATOM   3831 C  CA  . GLN B 2 64  ? 188.332 166.344 102.211 1.00 119.80 ? 55  GLN A CA  1 
ATOM   3832 C  C   . GLN B 2 64  ? 187.297 166.688 103.271 1.00 125.28 ? 55  GLN A C   1 
ATOM   3833 O  O   . GLN B 2 64  ? 187.629 166.866 104.446 1.00 125.94 ? 55  GLN A O   1 
ATOM   3834 C  CB  . GLN B 2 64  ? 188.536 164.829 102.130 1.00 116.46 ? 55  GLN A CB  1 
ATOM   3835 C  CG  . GLN B 2 64  ? 187.966 164.035 103.296 1.00 119.75 ? 55  GLN A CG  1 
ATOM   3836 C  CD  . GLN B 2 64  ? 188.946 163.887 104.441 1.00 121.24 ? 55  GLN A CD  1 
ATOM   3837 O  OE1 . GLN B 2 64  ? 189.847 164.706 104.612 1.00 121.26 ? 55  GLN A OE1 1 
ATOM   3838 N  NE2 . GLN B 2 64  ? 188.778 162.833 105.230 1.00 121.09 ? 55  GLN A NE2 1 
ATOM   3839 N  N   . VAL B 2 65  ? 186.047 166.818 102.845 1.00 128.70 ? 56  VAL A N   1 
ATOM   3840 C  CA  . VAL B 2 65  ? 184.944 167.136 103.742 1.00 126.77 ? 56  VAL A CA  1 
ATOM   3841 C  C   . VAL B 2 65  ? 184.092 165.877 103.905 1.00 126.21 ? 56  VAL A C   1 
ATOM   3842 O  O   . VAL B 2 65  ? 183.540 165.364 102.920 1.00 127.78 ? 56  VAL A O   1 
ATOM   3843 C  CB  . VAL B 2 65  ? 184.125 168.334 103.239 1.00 125.74 ? 56  VAL A CB  1 
ATOM   3844 C  CG1 . VAL B 2 65  ? 185.007 169.570 103.189 1.00 120.48 ? 56  VAL A CG1 1 
ATOM   3845 C  CG2 . VAL B 2 65  ? 183.552 168.084 101.847 1.00 123.51 ? 56  VAL A CG2 1 
ATOM   3846 N  N   . PRO B 2 66  ? 184.006 165.309 105.107 1.00 124.67 ? 57  PRO A N   1 
ATOM   3847 C  CA  . PRO B 2 66  ? 183.158 164.125 105.307 1.00 122.11 ? 57  PRO A CA  1 
ATOM   3848 C  C   . PRO B 2 66  ? 181.688 164.514 105.271 1.00 122.51 ? 57  PRO A C   1 
ATOM   3849 O  O   . PRO B 2 66  ? 181.243 165.378 106.029 1.00 120.66 ? 57  PRO A O   1 
ATOM   3850 C  CB  . PRO B 2 66  ? 183.578 163.614 106.692 1.00 116.83 ? 57  PRO A CB  1 
ATOM   3851 C  CG  . PRO B 2 66  ? 184.886 164.292 106.985 1.00 118.49 ? 57  PRO A CG  1 
ATOM   3852 C  CD  . PRO B 2 66  ? 184.812 165.616 106.297 1.00 123.88 ? 57  PRO A CD  1 
ATOM   3853 N  N   . MET B 2 67  ? 180.938 163.880 104.375 1.00 121.11 ? 58  MET A N   1 
ATOM   3854 C  CA  . MET B 2 67  ? 179.512 164.143 104.277 1.00 116.39 ? 58  MET A CA  1 
ATOM   3855 C  C   . MET B 2 67  ? 178.788 163.596 105.501 1.00 113.90 ? 58  MET A C   1 
ATOM   3856 O  O   . MET B 2 67  ? 179.246 162.654 106.152 1.00 113.15 ? 58  MET A O   1 
ATOM   3857 C  CB  . MET B 2 67  ? 178.943 163.520 103.005 1.00 113.92 ? 58  MET A CB  1 
ATOM   3858 C  CG  . MET B 2 67  ? 178.620 164.524 101.915 1.00 113.11 ? 58  MET A CG  1 
ATOM   3859 S  SD  . MET B 2 67  ? 177.570 163.827 100.628 1.00 129.31 ? 58  MET A SD  1 
ATOM   3860 C  CE  . MET B 2 67  ? 178.396 162.267 100.325 1.00 118.64 ? 58  MET A CE  1 
ATOM   3861 N  N   . CYS B 2 68  ? 177.642 164.199 105.813 1.00 111.89 ? 59  CYS A N   1 
ATOM   3862 C  CA  . CYS B 2 68  ? 176.884 163.783 106.985 1.00 109.33 ? 59  CYS A CA  1 
ATOM   3863 C  C   . CYS B 2 68  ? 176.307 162.381 106.852 1.00 108.22 ? 59  CYS A C   1 
ATOM   3864 O  O   . CYS B 2 68  ? 175.870 161.818 107.859 1.00 109.36 ? 59  CYS A O   1 
ATOM   3865 C  CB  . CYS B 2 68  ? 175.755 164.778 107.268 1.00 111.08 ? 59  CYS A CB  1 
ATOM   3866 S  SG  . CYS B 2 68  ? 176.296 166.402 107.864 1.00 122.36 ? 59  CYS A SG  1 
ATOM   3867 N  N   . LYS B 2 69  ? 176.294 161.805 105.649 1.00 110.22 ? 60  LYS A N   1 
ATOM   3868 C  CA  . LYS B 2 69  ? 175.758 160.460 105.484 1.00 112.84 ? 60  LYS A CA  1 
ATOM   3869 C  C   . LYS B 2 69  ? 176.627 159.400 106.150 1.00 116.04 ? 60  LYS A C   1 
ATOM   3870 O  O   . LYS B 2 69  ? 176.132 158.306 106.438 1.00 116.62 ? 60  LYS A O   1 
ATOM   3871 C  CB  . LYS B 2 69  ? 175.589 160.139 103.998 1.00 108.75 ? 60  LYS A CB  1 
ATOM   3872 C  CG  . LYS B 2 69  ? 176.730 159.335 103.397 1.00 108.38 ? 60  LYS A CG  1 
ATOM   3873 C  CD  . LYS B 2 69  ? 176.590 159.209 101.892 1.00 111.41 ? 60  LYS A CD  1 
ATOM   3874 C  CE  . LYS B 2 69  ? 177.682 158.326 101.311 1.00 114.30 ? 60  LYS A CE  1 
ATOM   3875 N  NZ  . LYS B 2 69  ? 177.253 157.661 100.050 1.00 108.63 ? 60  LYS A NZ  1 
ATOM   3876 N  N   . GLU B 2 70  ? 177.904 159.694 106.405 1.00 116.57 ? 61  GLU A N   1 
ATOM   3877 C  CA  . GLU B 2 70  ? 178.813 158.705 106.971 1.00 113.89 ? 61  GLU A CA  1 
ATOM   3878 C  C   . GLU B 2 70  ? 178.752 158.623 108.489 1.00 111.89 ? 61  GLU A C   1 
ATOM   3879 O  O   . GLU B 2 70  ? 179.252 157.648 109.060 1.00 111.62 ? 61  GLU A O   1 
ATOM   3880 C  CB  . GLU B 2 70  ? 180.252 158.999 106.536 1.00 114.23 ? 61  GLU A CB  1 
ATOM   3881 C  CG  . GLU B 2 70  ? 180.893 160.187 107.231 1.00 114.26 ? 61  GLU A CG  1 
ATOM   3882 C  CD  . GLU B 2 70  ? 181.760 159.779 108.404 1.00 115.94 ? 61  GLU A CD  1 
ATOM   3883 O  OE1 . GLU B 2 70  ? 182.006 158.567 108.568 1.00 118.05 ? 61  GLU A OE1 1 
ATOM   3884 O  OE2 . GLU B 2 70  ? 182.198 160.671 109.160 1.00 115.33 ? 61  GLU A OE2 1 
ATOM   3885 N  N   . TYR B 2 71  ? 178.158 159.608 109.156 1.00 109.98 ? 62  TYR A N   1 
ATOM   3886 C  CA  . TYR B 2 71  ? 178.028 159.547 110.602 1.00 107.64 ? 62  TYR A CA  1 
ATOM   3887 C  C   . TYR B 2 71  ? 176.945 158.545 110.992 1.00 106.39 ? 62  TYR A C   1 
ATOM   3888 O  O   . TYR B 2 71  ? 176.210 158.019 110.152 1.00 105.40 ? 62  TYR A O   1 
ATOM   3889 C  CB  . TYR B 2 71  ? 177.694 160.921 111.177 1.00 106.90 ? 62  TYR A CB  1 
ATOM   3890 C  CG  . TYR B 2 71  ? 178.784 161.947 111.008 1.00 109.60 ? 62  TYR A CG  1 
ATOM   3891 C  CD1 . TYR B 2 71  ? 178.913 162.662 109.828 1.00 110.16 ? 62  TYR A CD1 1 
ATOM   3892 C  CD2 . TYR B 2 71  ? 179.687 162.201 112.027 1.00 110.34 ? 62  TYR A CD2 1 
ATOM   3893 C  CE1 . TYR B 2 71  ? 179.907 163.602 109.670 1.00 112.96 ? 62  TYR A CE1 1 
ATOM   3894 C  CE2 . TYR B 2 71  ? 180.686 163.137 111.877 1.00 112.24 ? 62  TYR A CE2 1 
ATOM   3895 C  CZ  . TYR B 2 71  ? 180.792 163.835 110.697 1.00 113.90 ? 62  TYR A CZ  1 
ATOM   3896 O  OH  . TYR B 2 71  ? 181.788 164.771 110.543 1.00 111.26 ? 62  TYR A OH  1 
ATOM   3897 N  N   . GLU B 2 72  ? 176.859 158.272 112.289 1.00 106.18 ? 63  GLU A N   1 
ATOM   3898 C  CA  . GLU B 2 72  ? 175.812 157.395 112.786 1.00 106.53 ? 63  GLU A CA  1 
ATOM   3899 C  C   . GLU B 2 72  ? 174.455 158.082 112.701 1.00 103.21 ? 63  GLU A C   1 
ATOM   3900 O  O   . GLU B 2 72  ? 174.338 159.303 112.829 1.00 101.35 ? 63  GLU A O   1 
ATOM   3901 C  CB  . GLU B 2 72  ? 176.103 156.969 114.220 1.00 109.19 ? 63  GLU A CB  1 
ATOM   3902 C  CG  . GLU B 2 72  ? 177.449 156.291 114.397 1.00 111.02 ? 63  GLU A CG  1 
ATOM   3903 C  CD  . GLU B 2 72  ? 177.366 154.787 114.225 1.00 114.87 ? 63  GLU A CD  1 
ATOM   3904 O  OE1 . GLU B 2 72  ? 176.237 154.263 114.125 1.00 115.85 ? 63  GLU A OE1 1 
ATOM   3905 O  OE2 . GLU B 2 72  ? 178.428 154.130 114.188 1.00 115.09 ? 63  GLU A OE2 1 
ATOM   3906 N  N   . VAL B 2 73  ? 173.424 157.278 112.479 1.00 101.00 ? 64  VAL A N   1 
ATOM   3907 C  CA  . VAL B 2 73  ? 172.087 157.791 112.207 1.00 101.39 ? 64  VAL A CA  1 
ATOM   3908 C  C   . VAL B 2 73  ? 171.416 158.208 113.508 1.00 102.71 ? 64  VAL A C   1 
ATOM   3909 O  O   . VAL B 2 73  ? 171.427 157.464 114.495 1.00 105.73 ? 64  VAL A O   1 
ATOM   3910 C  CB  . VAL B 2 73  ? 171.254 156.739 111.464 1.00 101.41 ? 64  VAL A CB  1 
ATOM   3911 C  CG1 . VAL B 2 73  ? 171.411 155.393 112.137 1.00 101.23 ? 64  VAL A CG1 1 
ATOM   3912 C  CG2 . VAL B 2 73  ? 169.794 157.149 111.428 1.00 97.53  ? 64  VAL A CG2 1 
ATOM   3913 N  N   . LYS B 2 74  ? 170.831 159.402 113.511 1.00 99.12  ? 65  LYS A N   1 
ATOM   3914 C  CA  . LYS B 2 74  ? 170.027 159.888 114.624 1.00 89.86  ? 65  LYS A CA  1 
ATOM   3915 C  C   . LYS B 2 74  ? 168.558 159.693 114.277 1.00 87.13  ? 65  LYS A C   1 
ATOM   3916 O  O   . LYS B 2 74  ? 168.092 160.181 113.243 1.00 88.15  ? 65  LYS A O   1 
ATOM   3917 C  CB  . LYS B 2 74  ? 170.318 161.359 114.909 1.00 85.65  ? 65  LYS A CB  1 
ATOM   3918 C  CG  . LYS B 2 74  ? 171.201 161.597 116.109 1.00 90.33  ? 65  LYS A CG  1 
ATOM   3919 C  CD  . LYS B 2 74  ? 170.993 162.989 116.674 1.00 93.38  ? 65  LYS A CD  1 
ATOM   3920 C  CE  . LYS B 2 74  ? 170.264 162.941 118.000 1.00 95.15  ? 65  LYS A CE  1 
ATOM   3921 N  NZ  . LYS B 2 74  ? 170.567 164.127 118.844 1.00 97.41  ? 65  LYS A NZ  1 
ATOM   3922 N  N   . VAL B 2 75  ? 167.836 158.970 115.133 1.00 84.51  ? 66  VAL A N   1 
ATOM   3923 C  CA  . VAL B 2 75  ? 166.426 158.705 114.874 1.00 77.12  ? 66  VAL A CA  1 
ATOM   3924 C  C   . VAL B 2 75  ? 165.582 159.953 115.101 1.00 77.00  ? 66  VAL A C   1 
ATOM   3925 O  O   . VAL B 2 75  ? 164.565 160.154 114.425 1.00 78.93  ? 66  VAL A O   1 
ATOM   3926 C  CB  . VAL B 2 75  ? 165.953 157.528 115.741 1.00 78.65  ? 66  VAL A CB  1 
ATOM   3927 C  CG1 . VAL B 2 75  ? 166.314 157.773 117.191 1.00 83.31  ? 66  VAL A CG1 1 
ATOM   3928 C  CG2 . VAL B 2 75  ? 164.464 157.310 115.580 1.00 80.11  ? 66  VAL A CG2 1 
ATOM   3929 N  N   . ILE B 2 76  ? 165.983 160.809 116.043 1.00 78.39  ? 67  ILE A N   1 
ATOM   3930 C  CA  . ILE B 2 76  ? 165.183 161.982 116.382 1.00 77.83  ? 67  ILE A CA  1 
ATOM   3931 C  C   . ILE B 2 76  ? 165.049 162.910 115.183 1.00 78.35  ? 67  ILE A C   1 
ATOM   3932 O  O   . ILE B 2 76  ? 163.967 163.445 114.909 1.00 77.49  ? 67  ILE A O   1 
ATOM   3933 C  CB  . ILE B 2 76  ? 165.795 162.708 117.592 1.00 75.94  ? 67  ILE A CB  1 
ATOM   3934 C  CG1 . ILE B 2 76  ? 165.802 161.789 118.808 1.00 70.37  ? 67  ILE A CG1 1 
ATOM   3935 C  CG2 . ILE B 2 76  ? 165.021 163.970 117.902 1.00 77.27  ? 67  ILE A CG2 1 
ATOM   3936 C  CD1 . ILE B 2 76  ? 164.430 161.540 119.372 1.00 73.38  ? 67  ILE A CD1 1 
ATOM   3937 N  N   . GLY B 2 77  ? 166.143 163.124 114.453 1.00 80.25  ? 68  GLY A N   1 
ATOM   3938 C  CA  . GLY B 2 77  ? 166.078 163.988 113.289 1.00 76.33  ? 68  GLY A CA  1 
ATOM   3939 C  C   . GLY B 2 77  ? 165.138 163.462 112.224 1.00 75.63  ? 68  GLY A C   1 
ATOM   3940 O  O   . GLY B 2 77  ? 164.360 164.218 111.639 1.00 80.75  ? 68  GLY A O   1 
ATOM   3941 N  N   . TYR B 2 78  ? 165.193 162.159 111.957 1.00 71.76  ? 69  TYR A N   1 
ATOM   3942 C  CA  . TYR B 2 78  ? 164.288 161.583 110.971 1.00 74.12  ? 69  TYR A CA  1 
ATOM   3943 C  C   . TYR B 2 78  ? 162.845 161.675 111.439 1.00 74.83  ? 69  TYR A C   1 
ATOM   3944 O  O   . TYR B 2 78  ? 161.942 161.913 110.631 1.00 79.15  ? 69  TYR A O   1 
ATOM   3945 C  CB  . TYR B 2 78  ? 164.703 160.142 110.662 1.00 78.98  ? 69  TYR A CB  1 
ATOM   3946 C  CG  . TYR B 2 78  ? 163.759 159.367 109.766 1.00 84.16  ? 69  TYR A CG  1 
ATOM   3947 C  CD1 . TYR B 2 78  ? 164.122 159.043 108.469 1.00 87.69  ? 69  TYR A CD1 1 
ATOM   3948 C  CD2 . TYR B 2 78  ? 162.555 158.869 110.246 1.00 85.93  ? 69  TYR A CD2 1 
ATOM   3949 C  CE1 . TYR B 2 78  ? 163.283 158.322 107.653 1.00 96.20  ? 69  TYR A CE1 1 
ATOM   3950 C  CE2 . TYR B 2 78  ? 161.712 158.141 109.441 1.00 91.02  ? 69  TYR A CE2 1 
ATOM   3951 C  CZ  . TYR B 2 78  ? 162.078 157.871 108.143 1.00 99.79  ? 69  TYR A CZ  1 
ATOM   3952 O  OH  . TYR B 2 78  ? 161.239 157.139 107.334 1.00 105.95 ? 69  TYR A OH  1 
ATOM   3953 N  N   . ASN B 2 79  ? 162.605 161.496 112.736 1.00 73.43  ? 70  ASN A N   1 
ATOM   3954 C  CA  . ASN B 2 79  ? 161.248 161.644 113.246 1.00 74.15  ? 70  ASN A CA  1 
ATOM   3955 C  C   . ASN B 2 79  ? 160.740 163.067 113.053 1.00 76.35  ? 70  ASN A C   1 
ATOM   3956 O  O   . ASN B 2 79  ? 159.585 163.277 112.666 1.00 78.52  ? 70  ASN A O   1 
ATOM   3957 C  CB  . ASN B 2 79  ? 161.199 161.248 114.718 1.00 77.10  ? 70  ASN A CB  1 
ATOM   3958 C  CG  . ASN B 2 79  ? 159.790 161.074 115.219 1.00 81.07  ? 70  ASN A CG  1 
ATOM   3959 O  OD1 . ASN B 2 79  ? 158.900 160.667 114.475 1.00 82.36  ? 70  ASN A OD1 1 
ATOM   3960 N  ND2 . ASN B 2 79  ? 159.574 161.382 116.490 1.00 81.10  ? 70  ASN A ND2 1 
ATOM   3961 N  N   . LEU B 2 80  ? 161.593 164.061 113.305 1.00 76.43  ? 71  LEU A N   1 
ATOM   3962 C  CA  . LEU B 2 80  ? 161.175 165.448 113.122 1.00 72.96  ? 71  LEU A CA  1 
ATOM   3963 C  C   . LEU B 2 80  ? 160.923 165.767 111.652 1.00 71.22  ? 71  LEU A C   1 
ATOM   3964 O  O   . LEU B 2 80  ? 159.974 166.488 111.318 1.00 71.48  ? 71  LEU A O   1 
ATOM   3965 C  CB  . LEU B 2 80  ? 162.221 166.389 113.712 1.00 68.10  ? 71  LEU A CB  1 
ATOM   3966 C  CG  . LEU B 2 80  ? 162.367 166.264 115.226 1.00 64.02  ? 71  LEU A CG  1 
ATOM   3967 C  CD1 . LEU B 2 80  ? 163.361 167.267 115.766 1.00 64.55  ? 71  LEU A CD1 1 
ATOM   3968 C  CD2 . LEU B 2 80  ? 161.022 166.440 115.886 1.00 68.57  ? 71  LEU A CD2 1 
ATOM   3969 N  N   . MET B 2 81  ? 161.761 165.244 110.756 1.00 69.82  ? 72  MET A N   1 
ATOM   3970 C  CA  . MET B 2 81  ? 161.510 165.439 109.332 1.00 69.84  ? 72  MET A CA  1 
ATOM   3971 C  C   . MET B 2 81  ? 160.199 164.790 108.916 1.00 73.13  ? 72  MET A C   1 
ATOM   3972 O  O   . MET B 2 81  ? 159.447 165.351 108.111 1.00 76.44  ? 72  MET A O   1 
ATOM   3973 C  CB  . MET B 2 81  ? 162.662 164.888 108.496 1.00 70.79  ? 72  MET A CB  1 
ATOM   3974 C  CG  . MET B 2 81  ? 162.268 164.614 107.052 1.00 71.70  ? 72  MET A CG  1 
ATOM   3975 S  SD  . MET B 2 81  ? 163.536 163.785 106.091 1.00 91.88  ? 72  MET A SD  1 
ATOM   3976 C  CE  . MET B 2 81  ? 164.992 164.315 106.975 1.00 78.47  ? 72  MET A CE  1 
ATOM   3977 N  N   . GLN B 2 82  ? 159.914 163.601 109.443 1.00 70.39  ? 73  GLN A N   1 
ATOM   3978 C  CA  . GLN B 2 82  ? 158.638 162.965 109.152 1.00 71.84  ? 73  GLN A CA  1 
ATOM   3979 C  C   . GLN B 2 82  ? 157.484 163.801 109.678 1.00 74.79  ? 73  GLN A C   1 
ATOM   3980 O  O   . GLN B 2 82  ? 156.419 163.859 109.058 1.00 78.71  ? 73  GLN A O   1 
ATOM   3981 C  CB  . GLN B 2 82  ? 158.600 161.562 109.746 1.00 76.40  ? 73  GLN A CB  1 
ATOM   3982 C  CG  . GLN B 2 82  ? 159.431 160.556 108.985 1.00 82.45  ? 73  GLN A CG  1 
ATOM   3983 C  CD  . GLN B 2 82  ? 159.158 160.571 107.497 1.00 84.84  ? 73  GLN A CD  1 
ATOM   3984 O  OE1 . GLN B 2 82  ? 158.007 160.562 107.066 1.00 85.40  ? 73  GLN A OE1 1 
ATOM   3985 N  NE2 . GLN B 2 82  ? 160.219 160.580 106.702 1.00 84.78  ? 73  GLN A NE2 1 
ATOM   3986 N  N   . ALA B 2 83  ? 157.677 164.459 110.820 1.00 73.48  ? 74  ALA A N   1 
ATOM   3987 C  CA  . ALA B 2 83  ? 156.649 165.356 111.340 1.00 72.75  ? 74  ALA A CA  1 
ATOM   3988 C  C   . ALA B 2 83  ? 156.395 166.512 110.383 1.00 70.10  ? 74  ALA A C   1 
ATOM   3989 O  O   . ALA B 2 83  ? 155.243 166.865 110.104 1.00 68.70  ? 74  ALA A O   1 
ATOM   3990 C  CB  . ALA B 2 83  ? 157.059 165.884 112.711 1.00 70.45  ? 74  ALA A CB  1 
ATOM   3991 N  N   . MET B 2 84  ? 157.465 167.117 109.871 1.00 72.48  ? 75  MET A N   1 
ATOM   3992 C  CA  . MET B 2 84  ? 157.297 168.224 108.932 1.00 67.91  ? 75  MET A CA  1 
ATOM   3993 C  C   . MET B 2 84  ? 156.610 167.762 107.653 1.00 68.20  ? 75  MET A C   1 
ATOM   3994 O  O   . MET B 2 84  ? 155.725 168.450 107.127 1.00 70.14  ? 75  MET A O   1 
ATOM   3995 C  CB  . MET B 2 84  ? 158.647 168.859 108.612 1.00 64.33  ? 75  MET A CB  1 
ATOM   3996 C  CG  . MET B 2 84  ? 158.550 170.056 107.696 1.00 57.30  ? 75  MET A CG  1 
ATOM   3997 S  SD  . MET B 2 84  ? 160.136 170.542 107.014 1.00 64.86  ? 75  MET A SD  1 
ATOM   3998 C  CE  . MET B 2 84  ? 159.618 171.198 105.442 1.00 57.45  ? 75  MET A CE  1 
ATOM   3999 N  N   . ARG B 2 85  ? 157.008 166.600 107.136 1.00 70.77  ? 76  ARG A N   1 
ATOM   4000 C  CA  . ARG B 2 85  ? 156.386 166.076 105.926 1.00 76.04  ? 76  ARG A CA  1 
ATOM   4001 C  C   . ARG B 2 85  ? 154.916 165.753 106.154 1.00 76.82  ? 76  ARG A C   1 
ATOM   4002 O  O   . ARG B 2 85  ? 154.080 165.995 105.278 1.00 76.65  ? 76  ARG A O   1 
ATOM   4003 C  CB  . ARG B 2 85  ? 157.137 164.839 105.443 1.00 79.09  ? 76  ARG A CB  1 
ATOM   4004 C  CG  . ARG B 2 85  ? 158.522 165.134 104.915 1.00 79.15  ? 76  ARG A CG  1 
ATOM   4005 C  CD  . ARG B 2 85  ? 159.277 163.856 104.625 1.00 87.28  ? 76  ARG A CD  1 
ATOM   4006 N  NE  . ARG B 2 85  ? 158.826 163.220 103.396 1.00 91.56  ? 76  ARG A NE  1 
ATOM   4007 C  CZ  . ARG B 2 85  ? 157.996 162.189 103.351 1.00 92.30  ? 76  ARG A CZ  1 
ATOM   4008 N  NH1 . ARG B 2 85  ? 157.496 161.656 104.453 1.00 90.69  ? 76  ARG A NH1 1 
ATOM   4009 N  NH2 . ARG B 2 85  ? 157.660 161.678 102.170 1.00 92.28  ? 76  ARG A NH2 1 
ATOM   4010 N  N   . PHE B 2 86  ? 154.583 165.196 107.319 1.00 75.46  ? 77  PHE A N   1 
ATOM   4011 C  CA  . PHE B 2 86  ? 153.185 164.935 107.636 1.00 76.25  ? 77  PHE A CA  1 
ATOM   4012 C  C   . PHE B 2 86  ? 152.393 166.229 107.713 1.00 76.43  ? 77  PHE A C   1 
ATOM   4013 O  O   . PHE B 2 86  ? 151.252 166.294 107.245 1.00 80.47  ? 77  PHE A O   1 
ATOM   4014 C  CB  . PHE B 2 86  ? 153.071 164.173 108.951 1.00 77.41  ? 77  PHE A CB  1 
ATOM   4015 C  CG  . PHE B 2 86  ? 151.678 164.125 109.496 1.00 78.83  ? 77  PHE A CG  1 
ATOM   4016 C  CD1 . PHE B 2 86  ? 150.701 163.389 108.858 1.00 84.95  ? 77  PHE A CD1 1 
ATOM   4017 C  CD2 . PHE B 2 86  ? 151.342 164.823 110.636 1.00 74.20  ? 77  PHE A CD2 1 
ATOM   4018 C  CE1 . PHE B 2 86  ? 149.419 163.345 109.351 1.00 82.74  ? 77  PHE A CE1 1 
ATOM   4019 C  CE2 . PHE B 2 86  ? 150.060 164.781 111.130 1.00 78.43  ? 77  PHE A CE2 1 
ATOM   4020 C  CZ  . PHE B 2 86  ? 149.098 164.040 110.486 1.00 81.18  ? 77  PHE A CZ  1 
ATOM   4021 N  N   . ALA B 2 87  ? 152.975 167.267 108.315 1.00 70.68  ? 78  ALA A N   1 
ATOM   4022 C  CA  . ALA B 2 87  ? 152.289 168.551 108.373 1.00 70.50  ? 78  ALA A CA  1 
ATOM   4023 C  C   . ALA B 2 87  ? 152.023 169.086 106.976 1.00 76.89  ? 78  ALA A C   1 
ATOM   4024 O  O   . ALA B 2 87  ? 150.917 169.552 106.683 1.00 81.37  ? 78  ALA A O   1 
ATOM   4025 C  CB  . ALA B 2 87  ? 153.108 169.552 109.180 1.00 64.96  ? 78  ALA A CB  1 
ATOM   4026 N  N   . VAL B 2 88  ? 153.018 169.004 106.093 1.00 74.54  ? 79  VAL A N   1 
ATOM   4027 C  CA  . VAL B 2 88  ? 152.838 169.512 104.736 1.00 71.06  ? 79  VAL A CA  1 
ATOM   4028 C  C   . VAL B 2 88  ? 151.789 168.699 103.985 1.00 77.49  ? 79  VAL A C   1 
ATOM   4029 O  O   . VAL B 2 88  ? 150.956 169.256 103.262 1.00 80.52  ? 79  VAL A O   1 
ATOM   4030 C  CB  . VAL B 2 88  ? 154.179 169.537 103.989 1.00 65.50  ? 79  VAL A CB  1 
ATOM   4031 C  CG1 . VAL B 2 88  ? 153.941 169.641 102.507 1.00 72.82  ? 79  VAL A CG1 1 
ATOM   4032 C  CG2 . VAL B 2 88  ? 155.014 170.699 104.465 1.00 62.38  ? 79  VAL A CG2 1 
ATOM   4033 N  N   . GLU B 2 89  ? 151.810 167.372 104.133 1.00 77.04  ? 80  GLU A N   1 
ATOM   4034 C  CA  . GLU B 2 89  ? 150.825 166.545 103.441 1.00 82.02  ? 80  GLU A CA  1 
ATOM   4035 C  C   . GLU B 2 89  ? 149.416 166.808 103.953 1.00 87.15  ? 80  GLU A C   1 
ATOM   4036 O  O   . GLU B 2 89  ? 148.466 166.870 103.165 1.00 91.00  ? 80  GLU A O   1 
ATOM   4037 C  CB  . GLU B 2 89  ? 151.170 165.066 103.589 1.00 86.58  ? 80  GLU A CB  1 
ATOM   4038 C  CG  . GLU B 2 89  ? 150.388 164.169 102.645 1.00 93.69  ? 80  GLU A CG  1 
ATOM   4039 C  CD  . GLU B 2 89  ? 150.842 162.725 102.694 1.00 100.38 ? 80  GLU A CD  1 
ATOM   4040 O  OE1 . GLU B 2 89  ? 150.758 162.114 103.780 1.00 97.56  ? 80  GLU A OE1 1 
ATOM   4041 O  OE2 . GLU B 2 89  ? 151.278 162.199 101.649 1.00 101.79 ? 80  GLU A OE2 1 
ATOM   4042 N  N   . GLU B 2 90  ? 149.256 166.955 105.270 1.00 84.62  ? 81  GLU A N   1 
ATOM   4043 C  CA  . GLU B 2 90  ? 147.948 167.284 105.823 1.00 87.77  ? 81  GLU A CA  1 
ATOM   4044 C  C   . GLU B 2 90  ? 147.486 168.650 105.344 1.00 86.32  ? 81  GLU A C   1 
ATOM   4045 O  O   . GLU B 2 90  ? 146.291 168.870 105.119 1.00 90.06  ? 81  GLU A O   1 
ATOM   4046 C  CB  . GLU B 2 90  ? 148.001 167.241 107.348 1.00 86.53  ? 81  GLU A CB  1 
ATOM   4047 C  CG  . GLU B 2 90  ? 146.684 166.876 108.002 1.00 94.48  ? 81  GLU A CG  1 
ATOM   4048 C  CD  . GLU B 2 90  ? 146.288 165.438 107.748 1.00 99.31  ? 81  GLU A CD  1 
ATOM   4049 O  OE1 . GLU B 2 90  ? 147.191 164.595 107.570 1.00 93.04  ? 81  GLU A OE1 1 
ATOM   4050 O  OE2 . GLU B 2 90  ? 145.074 165.151 107.729 1.00 102.99 ? 81  GLU A OE2 1 
ATOM   4051 N  N   . ILE B 2 91  ? 148.421 169.585 105.195 1.00 80.05  ? 82  ILE A N   1 
ATOM   4052 C  CA  . ILE B 2 91  ? 148.088 170.903 104.671 1.00 79.02  ? 82  ILE A CA  1 
ATOM   4053 C  C   . ILE B 2 91  ? 147.601 170.787 103.235 1.00 83.61  ? 82  ILE A C   1 
ATOM   4054 O  O   . ILE B 2 91  ? 146.619 171.425 102.839 1.00 90.15  ? 82  ILE A O   1 
ATOM   4055 C  CB  . ILE B 2 91  ? 149.317 171.816 104.785 1.00 77.04  ? 82  ILE A CB  1 
ATOM   4056 C  CG1 . ILE B 2 91  ? 149.333 172.491 106.148 1.00 76.67  ? 82  ILE A CG1 1 
ATOM   4057 C  CG2 . ILE B 2 91  ? 149.298 172.873 103.704 1.00 75.61  ? 82  ILE A CG2 1 
ATOM   4058 C  CD1 . ILE B 2 91  ? 150.564 173.287 106.386 1.00 75.69  ? 82  ILE A CD1 1 
ATOM   4059 N  N   . ASN B 2 92  ? 148.283 169.965 102.434 1.00 81.70  ? 83  ASN A N   1 
ATOM   4060 C  CA  . ASN B 2 92  ? 147.896 169.779 101.040 1.00 81.57  ? 83  ASN A CA  1 
ATOM   4061 C  C   . ASN B 2 92  ? 146.533 169.109 100.924 1.00 87.64  ? 83  ASN A C   1 
ATOM   4062 O  O   . ASN B 2 92  ? 145.743 169.453 100.039 1.00 88.57  ? 83  ASN A O   1 
ATOM   4063 C  CB  . ASN B 2 92  ? 148.956 168.960 100.309 1.00 80.40  ? 83  ASN A CB  1 
ATOM   4064 C  CG  . ASN B 2 92  ? 150.123 169.800 99.852  1.00 77.26  ? 83  ASN A CG  1 
ATOM   4065 O  OD1 . ASN B 2 92  ? 150.088 171.025 99.937  1.00 75.31  ? 83  ASN A OD1 1 
ATOM   4066 N  ND2 . ASN B 2 92  ? 151.167 169.147 99.361  1.00 77.56  ? 83  ASN A ND2 1 
ATOM   4067 N  N   . ASN B 2 93  ? 146.247 168.143 101.798 1.00 88.35  ? 84  ASN A N   1 
ATOM   4068 C  CA  . ASN B 2 93  ? 144.949 167.476 101.773 1.00 89.66  ? 84  ASN A CA  1 
ATOM   4069 C  C   . ASN B 2 93  ? 143.814 168.475 101.957 1.00 90.80  ? 84  ASN A C   1 
ATOM   4070 O  O   . ASN B 2 93  ? 142.830 168.461 101.210 1.00 90.46  ? 84  ASN A O   1 
ATOM   4071 C  CB  . ASN B 2 93  ? 144.874 166.425 102.877 1.00 95.57  ? 84  ASN A CB  1 
ATOM   4072 C  CG  . ASN B 2 93  ? 145.535 165.119 102.510 1.00 101.14 ? 84  ASN A CG  1 
ATOM   4073 O  OD1 . ASN B 2 93  ? 146.500 165.079 101.750 1.00 97.90  ? 84  ASN A OD1 1 
ATOM   4074 N  ND2 . ASN B 2 93  ? 145.007 164.035 103.072 1.00 109.08 ? 84  ASN A ND2 1 
ATOM   4075 N  N   . ASP B 2 94  ? 143.938 169.348 102.953 1.00 93.10  ? 85  ASP A N   1 
ATOM   4076 C  CA  . ASP B 2 94  ? 142.822 170.186 103.364 1.00 95.14  ? 85  ASP A CA  1 
ATOM   4077 C  C   . ASP B 2 94  ? 142.450 171.179 102.274 1.00 100.56 ? 85  ASP A C   1 
ATOM   4078 O  O   . ASP B 2 94  ? 143.316 171.757 101.613 1.00 101.22 ? 85  ASP A O   1 
ATOM   4079 C  CB  . ASP B 2 94  ? 143.167 170.930 104.652 1.00 96.31  ? 85  ASP A CB  1 
ATOM   4080 C  CG  . ASP B 2 94  ? 143.225 170.014 105.856 1.00 104.14 ? 85  ASP A CG  1 
ATOM   4081 O  OD1 . ASP B 2 94  ? 142.987 168.799 105.694 1.00 104.88 ? 85  ASP A OD1 1 
ATOM   4082 O  OD2 . ASP B 2 94  ? 143.509 170.507 106.967 1.00 108.30 ? 85  ASP A OD2 1 
ATOM   4083 N  N   . SER B 2 95  ? 141.147 171.367 102.086 1.00 106.41 ? 86  SER A N   1 
ATOM   4084 C  CA  . SER B 2 95  ? 140.622 172.329 101.129 1.00 107.76 ? 86  SER A CA  1 
ATOM   4085 C  C   . SER B 2 95  ? 140.298 173.673 101.762 1.00 105.23 ? 86  SER A C   1 
ATOM   4086 O  O   . SER B 2 95  ? 139.826 174.572 101.060 1.00 101.44 ? 86  SER A O   1 
ATOM   4087 C  CB  . SER B 2 95  ? 139.370 171.769 100.451 1.00 104.06 ? 86  SER A CB  1 
ATOM   4088 O  OG  . SER B 2 95  ? 138.310 171.631 101.380 1.00 105.73 ? 86  SER A OG  1 
ATOM   4089 N  N   . SER B 2 96  ? 140.532 173.833 103.062 1.00 104.34 ? 87  SER A N   1 
ATOM   4090 C  CA  . SER B 2 96  ? 140.268 175.089 103.749 1.00 103.39 ? 87  SER A CA  1 
ATOM   4091 C  C   . SER B 2 96  ? 141.517 175.934 103.937 1.00 104.75 ? 87  SER A C   1 
ATOM   4092 O  O   . SER B 2 96  ? 141.464 177.153 103.757 1.00 105.31 ? 87  SER A O   1 
ATOM   4093 C  CB  . SER B 2 96  ? 139.628 174.822 105.114 1.00 101.74 ? 87  SER A CB  1 
ATOM   4094 O  OG  . SER B 2 96  ? 140.607 174.486 106.079 1.00 100.90 ? 87  SER A OG  1 
ATOM   4095 N  N   . LEU B 2 97  ? 142.643 175.319 104.285 1.00 101.56 ? 88  LEU A N   1 
ATOM   4096 C  CA  . LEU B 2 97  ? 143.897 176.034 104.485 1.00 98.67  ? 88  LEU A CA  1 
ATOM   4097 C  C   . LEU B 2 97  ? 144.706 175.977 103.197 1.00 99.25  ? 88  LEU A C   1 
ATOM   4098 O  O   . LEU B 2 97  ? 145.028 174.887 102.712 1.00 97.02  ? 88  LEU A O   1 
ATOM   4099 C  CB  . LEU B 2 97  ? 144.691 175.436 105.643 1.00 90.60  ? 88  LEU A CB  1 
ATOM   4100 C  CG  . LEU B 2 97  ? 146.010 176.146 105.940 1.00 83.28  ? 88  LEU A CG  1 
ATOM   4101 C  CD1 . LEU B 2 97  ? 145.765 177.392 106.763 1.00 76.65  ? 88  LEU A CD1 1 
ATOM   4102 C  CD2 . LEU B 2 97  ? 146.969 175.218 106.648 1.00 78.42  ? 88  LEU A CD2 1 
ATOM   4103 N  N   . LEU B 2 98  ? 145.036 177.150 102.655 1.00 96.87  ? 89  LEU A N   1 
ATOM   4104 C  CA  . LEU B 2 98  ? 145.754 177.274 101.392 1.00 95.82  ? 89  LEU A CA  1 
ATOM   4105 C  C   . LEU B 2 98  ? 145.082 176.432 100.317 1.00 96.49  ? 89  LEU A C   1 
ATOM   4106 O  O   . LEU B 2 98  ? 145.618 175.390 99.922  1.00 95.48  ? 89  LEU A O   1 
ATOM   4107 C  CB  . LEU B 2 98  ? 147.217 176.857 101.547 1.00 91.25  ? 89  LEU A CB  1 
ATOM   4108 C  CG  . LEU B 2 98  ? 148.207 177.968 101.883 1.00 81.00  ? 89  LEU A CG  1 
ATOM   4109 C  CD1 . LEU B 2 98  ? 149.612 177.409 101.961 1.00 76.35  ? 89  LEU A CD1 1 
ATOM   4110 C  CD2 . LEU B 2 98  ? 148.127 179.078 100.857 1.00 79.93  ? 89  LEU A CD2 1 
ATOM   4111 N  N   . PRO B 2 99  ? 143.906 176.831 99.834  1.00 96.95  ? 90  PRO A N   1 
ATOM   4112 C  CA  . PRO B 2 99  ? 143.236 176.048 98.790  1.00 97.43  ? 90  PRO A CA  1 
ATOM   4113 C  C   . PRO B 2 99  ? 143.770 176.418 97.414  1.00 97.79  ? 90  PRO A C   1 
ATOM   4114 O  O   . PRO B 2 99  ? 143.903 177.597 97.081  1.00 101.12 ? 90  PRO A O   1 
ATOM   4115 C  CB  . PRO B 2 99  ? 141.764 176.436 98.947  1.00 102.61 ? 90  PRO A CB  1 
ATOM   4116 C  CG  . PRO B 2 99  ? 141.805 177.814 99.517  1.00 106.42 ? 90  PRO A CG  1 
ATOM   4117 C  CD  . PRO B 2 99  ? 143.119 178.008 100.232 1.00 100.25 ? 90  PRO A CD  1 
ATOM   4118 N  N   . GLY B 2 100 ? 144.081 175.400 96.619  1.00 96.71  ? 91  GLY A N   1 
ATOM   4119 C  CA  . GLY B 2 100 ? 144.558 175.606 95.271  1.00 96.22  ? 91  GLY A CA  1 
ATOM   4120 C  C   . GLY B 2 100 ? 146.037 175.882 95.141  1.00 93.88  ? 91  GLY A C   1 
ATOM   4121 O  O   . GLY B 2 100 ? 146.526 176.007 94.011  1.00 91.21  ? 91  GLY A O   1 
ATOM   4122 N  N   . VAL B 2 101 ? 146.769 175.977 96.247  1.00 91.28  ? 92  VAL A N   1 
ATOM   4123 C  CA  . VAL B 2 101 ? 148.209 176.205 96.229  1.00 86.31  ? 92  VAL A CA  1 
ATOM   4124 C  C   . VAL B 2 101 ? 148.880 174.982 96.830  1.00 81.25  ? 92  VAL A C   1 
ATOM   4125 O  O   . VAL B 2 101 ? 148.610 174.624 97.982  1.00 82.45  ? 92  VAL A O   1 
ATOM   4126 C  CB  . VAL B 2 101 ? 148.602 177.472 97.003  1.00 83.96  ? 92  VAL A CB  1 
ATOM   4127 C  CG1 . VAL B 2 101 ? 150.069 177.426 97.369  1.00 81.08  ? 92  VAL A CG1 1 
ATOM   4128 C  CG2 . VAL B 2 101 ? 148.302 178.706 96.186  1.00 85.42  ? 92  VAL A CG2 1 
ATOM   4129 N  N   . LEU B 2 102 ? 149.753 174.345 96.061  1.00 78.52  ? 93  LEU A N   1 
ATOM   4130 C  CA  . LEU B 2 102 ? 150.480 173.188 96.559  1.00 76.28  ? 93  LEU A CA  1 
ATOM   4131 C  C   . LEU B 2 102 ? 151.679 173.665 97.365  1.00 76.28  ? 93  LEU A C   1 
ATOM   4132 O  O   . LEU B 2 102 ? 152.546 174.368 96.839  1.00 83.20  ? 93  LEU A O   1 
ATOM   4133 C  CB  . LEU B 2 102 ? 150.923 172.291 95.406  1.00 74.60  ? 93  LEU A CB  1 
ATOM   4134 C  CG  . LEU B 2 102 ? 149.833 171.814 94.449  1.00 74.09  ? 93  LEU A CG  1 
ATOM   4135 C  CD1 . LEU B 2 102 ? 150.409 170.840 93.440  1.00 73.96  ? 93  LEU A CD1 1 
ATOM   4136 C  CD2 . LEU B 2 102 ? 148.685 171.178 95.211  1.00 67.88  ? 93  LEU A CD2 1 
ATOM   4137 N  N   . LEU B 2 103 ? 151.726 173.294 98.639  1.00 72.62  ? 94  LEU A N   1 
ATOM   4138 C  CA  . LEU B 2 103 ? 152.838 173.653 99.509  1.00 71.71  ? 94  LEU A CA  1 
ATOM   4139 C  C   . LEU B 2 103 ? 153.920 172.593 99.372  1.00 74.13  ? 94  LEU A C   1 
ATOM   4140 O  O   . LEU B 2 103 ? 153.768 171.473 99.865  1.00 74.71  ? 94  LEU A O   1 
ATOM   4141 C  CB  . LEU B 2 103 ? 152.376 173.775 100.957 1.00 71.13  ? 94  LEU A CB  1 
ATOM   4142 C  CG  . LEU B 2 103 ? 153.202 174.715 101.829 1.00 62.83  ? 94  LEU A CG  1 
ATOM   4143 C  CD1 . LEU B 2 103 ? 153.296 176.078 101.182 1.00 65.59  ? 94  LEU A CD1 1 
ATOM   4144 C  CD2 . LEU B 2 103 ? 152.596 174.819 103.210 1.00 64.59  ? 94  LEU A CD2 1 
ATOM   4145 N  N   . GLY B 2 104 ? 155.005 172.938 98.689  1.00 76.76  ? 95  GLY A N   1 
ATOM   4146 C  CA  . GLY B 2 104 ? 156.134 172.050 98.547  1.00 75.00  ? 95  GLY A CA  1 
ATOM   4147 C  C   . GLY B 2 104 ? 157.241 172.382 99.532  1.00 72.05  ? 95  GLY A C   1 
ATOM   4148 O  O   . GLY B 2 104 ? 157.255 173.432 100.164 1.00 68.52  ? 95  GLY A O   1 
ATOM   4149 N  N   . TYR B 2 105 ? 158.185 171.454 99.651  1.00 73.40  ? 96  TYR A N   1 
ATOM   4150 C  CA  . TYR B 2 105 ? 159.296 171.640 100.569 1.00 71.09  ? 96  TYR A CA  1 
ATOM   4151 C  C   . TYR B 2 105 ? 160.552 171.007 99.998  1.00 72.25  ? 96  TYR A C   1 
ATOM   4152 O  O   . TYR B 2 105 ? 160.489 170.037 99.240  1.00 78.24  ? 96  TYR A O   1 
ATOM   4153 C  CB  . TYR B 2 105 ? 158.987 171.050 101.945 1.00 68.32  ? 96  TYR A CB  1 
ATOM   4154 C  CG  . TYR B 2 105 ? 158.595 169.598 101.925 1.00 69.31  ? 96  TYR A CG  1 
ATOM   4155 C  CD1 . TYR B 2 105 ? 157.273 169.226 101.758 1.00 71.68  ? 96  TYR A CD1 1 
ATOM   4156 C  CD2 . TYR B 2 105 ? 159.538 168.600 102.082 1.00 69.50  ? 96  TYR A CD2 1 
ATOM   4157 C  CE1 . TYR B 2 105 ? 156.900 167.905 101.744 1.00 75.36  ? 96  TYR A CE1 1 
ATOM   4158 C  CE2 . TYR B 2 105 ? 159.173 167.271 102.068 1.00 78.22  ? 96  TYR A CE2 1 
ATOM   4159 C  CZ  . TYR B 2 105 ? 157.850 166.931 101.898 1.00 79.94  ? 96  TYR A CZ  1 
ATOM   4160 O  OH  . TYR B 2 105 ? 157.470 165.610 101.883 1.00 82.84  ? 96  TYR A OH  1 
ATOM   4161 N  N   . GLU B 2 106 ? 161.697 171.569 100.379 1.00 66.16  ? 97  GLU A N   1 
ATOM   4162 C  CA  . GLU B 2 106 ? 163.011 171.063 99.992  1.00 66.62  ? 97  GLU A CA  1 
ATOM   4163 C  C   . GLU B 2 106 ? 163.782 170.812 101.281 1.00 65.17  ? 97  GLU A C   1 
ATOM   4164 O  O   . GLU B 2 106 ? 164.545 171.667 101.734 1.00 66.24  ? 97  GLU A O   1 
ATOM   4165 C  CB  . GLU B 2 106 ? 163.734 172.041 99.079  1.00 68.06  ? 97  GLU A CB  1 
ATOM   4166 C  CG  . GLU B 2 106 ? 165.092 171.554 98.612  1.00 74.14  ? 97  GLU A CG  1 
ATOM   4167 C  CD  . GLU B 2 106 ? 165.047 170.905 97.245  1.00 83.07  ? 97  GLU A CD  1 
ATOM   4168 O  OE1 . GLU B 2 106 ? 164.187 171.294 96.428  1.00 83.25  ? 97  GLU A OE1 1 
ATOM   4169 O  OE2 . GLU B 2 106 ? 165.874 170.006 96.985  1.00 81.27  ? 97  GLU A OE2 1 
ATOM   4170 N  N   . ILE B 2 107 ? 163.582 169.639 101.867 1.00 67.40  ? 98  ILE A N   1 
ATOM   4171 C  CA  . ILE B 2 107 ? 164.253 169.278 103.109 1.00 63.50  ? 98  ILE A CA  1 
ATOM   4172 C  C   . ILE B 2 107 ? 165.682 168.878 102.793 1.00 64.51  ? 98  ILE A C   1 
ATOM   4173 O  O   . ILE B 2 107 ? 165.925 168.057 101.904 1.00 72.11  ? 98  ILE A O   1 
ATOM   4174 C  CB  . ILE B 2 107 ? 163.514 168.136 103.819 1.00 65.06  ? 98  ILE A CB  1 
ATOM   4175 C  CG1 . ILE B 2 107 ? 162.188 168.620 104.388 1.00 66.96  ? 98  ILE A CG1 1 
ATOM   4176 C  CG2 . ILE B 2 107 ? 164.365 167.561 104.923 1.00 64.47  ? 98  ILE A CG2 1 
ATOM   4177 C  CD1 . ILE B 2 107 ? 161.371 167.511 104.981 1.00 71.51  ? 98  ILE A CD1 1 
ATOM   4178 N  N   . VAL B 2 108 ? 166.631 169.459 103.513 1.00 61.90  ? 99  VAL A N   1 
ATOM   4179 C  CA  . VAL B 2 108 ? 168.033 169.101 103.368 1.00 66.40  ? 99  VAL A CA  1 
ATOM   4180 C  C   . VAL B 2 108 ? 168.576 168.742 104.740 1.00 63.53  ? 99  VAL A C   1 
ATOM   4181 O  O   . VAL B 2 108 ? 168.078 169.206 105.769 1.00 65.48  ? 99  VAL A O   1 
ATOM   4182 C  CB  . VAL B 2 108 ? 168.855 170.233 102.716 1.00 63.14  ? 99  VAL A CB  1 
ATOM   4183 C  CG1 . VAL B 2 108 ? 169.322 171.210 103.750 1.00 57.15  ? 99  VAL A CG1 1 
ATOM   4184 C  CG2 . VAL B 2 108 ? 170.031 169.663 101.959 1.00 70.34  ? 99  VAL A CG2 1 
ATOM   4185 N  N   . ASP B 2 109 ? 169.590 167.888 104.752 1.00 70.75  ? 100 ASP A N   1 
ATOM   4186 C  CA  . ASP B 2 109 ? 170.152 167.367 105.988 1.00 73.53  ? 100 ASP A CA  1 
ATOM   4187 C  C   . ASP B 2 109 ? 171.220 168.321 106.498 1.00 78.78  ? 100 ASP A C   1 
ATOM   4188 O  O   . ASP B 2 109 ? 172.198 168.601 105.798 1.00 84.65  ? 100 ASP A O   1 
ATOM   4189 C  CB  . ASP B 2 109 ? 170.737 165.975 105.765 1.00 81.47  ? 100 ASP A CB  1 
ATOM   4190 C  CG  . ASP B 2 109 ? 171.513 165.470 106.961 1.00 85.34  ? 100 ASP A CG  1 
ATOM   4191 O  OD1 . ASP B 2 109 ? 171.163 165.839 108.099 1.00 85.19  ? 100 ASP A OD1 1 
ATOM   4192 O  OD2 . ASP B 2 109 ? 172.476 164.702 106.763 1.00 88.76  ? 100 ASP A OD2 1 
ATOM   4193 N  N   . VAL B 2 110 ? 171.036 168.810 107.716 1.00 79.16  ? 101 VAL A N   1 
ATOM   4194 C  CA  . VAL B 2 110 ? 172.014 169.647 108.395 1.00 78.73  ? 101 VAL A CA  1 
ATOM   4195 C  C   . VAL B 2 110 ? 172.614 168.831 109.529 1.00 86.23  ? 101 VAL A C   1 
ATOM   4196 O  O   . VAL B 2 110 ? 171.892 168.152 110.266 1.00 90.70  ? 101 VAL A O   1 
ATOM   4197 C  CB  . VAL B 2 110 ? 171.383 170.960 108.900 1.00 73.16  ? 101 VAL A CB  1 
ATOM   4198 C  CG1 . VAL B 2 110 ? 170.479 170.727 110.096 1.00 71.22  ? 101 VAL A CG1 1 
ATOM   4199 C  CG2 . VAL B 2 110 ? 172.457 171.951 109.265 1.00 75.68  ? 101 VAL A CG2 1 
ATOM   4200 N  N   . CYS B 2 111 ? 173.934 168.843 109.632 1.00 90.58  ? 102 CYS A N   1 
ATOM   4201 C  CA  . CYS B 2 111 ? 174.544 168.191 110.773 1.00 94.89  ? 102 CYS A CA  1 
ATOM   4202 C  C   . CYS B 2 111 ? 174.380 169.074 112.005 1.00 96.92  ? 102 CYS A C   1 
ATOM   4203 O  O   . CYS B 2 111 ? 173.934 170.220 111.924 1.00 99.10  ? 102 CYS A O   1 
ATOM   4204 C  CB  . CYS B 2 111 ? 176.014 167.889 110.498 1.00 99.34  ? 102 CYS A CB  1 
ATOM   4205 S  SG  . CYS B 2 111 ? 176.312 166.216 109.887 1.00 108.63 ? 102 CYS A SG  1 
ATOM   4206 N  N   . TYR B 2 112 ? 174.725 168.521 113.166 1.00 97.33  ? 103 TYR A N   1 
ATOM   4207 C  CA  . TYR B 2 112 ? 174.585 169.278 114.404 1.00 96.58  ? 103 TYR A CA  1 
ATOM   4208 C  C   . TYR B 2 112 ? 175.430 170.547 114.365 1.00 97.60  ? 103 TYR A C   1 
ATOM   4209 O  O   . TYR B 2 112 ? 174.958 171.633 114.720 1.00 100.08 ? 103 TYR A O   1 
ATOM   4210 C  CB  . TYR B 2 112 ? 174.951 168.384 115.592 1.00 99.85  ? 103 TYR A CB  1 
ATOM   4211 C  CG  . TYR B 2 112 ? 175.741 169.050 116.692 1.00 101.95 ? 103 TYR A CG  1 
ATOM   4212 C  CD1 . TYR B 2 112 ? 175.131 169.914 117.590 1.00 101.52 ? 103 TYR A CD1 1 
ATOM   4213 C  CD2 . TYR B 2 112 ? 177.090 168.776 116.861 1.00 101.49 ? 103 TYR A CD2 1 
ATOM   4214 C  CE1 . TYR B 2 112 ? 175.851 170.513 118.604 1.00 101.22 ? 103 TYR A CE1 1 
ATOM   4215 C  CE2 . TYR B 2 112 ? 177.816 169.363 117.874 1.00 103.74 ? 103 TYR A CE2 1 
ATOM   4216 C  CZ  . TYR B 2 112 ? 177.193 170.233 118.742 1.00 104.87 ? 103 TYR A CZ  1 
ATOM   4217 O  OH  . TYR B 2 112 ? 177.915 170.824 119.753 1.00 103.27 ? 103 TYR A OH  1 
ATOM   4218 N  N   . ILE B 2 113 ? 176.682 170.432 113.922 1.00 99.40  ? 104 ILE A N   1 
ATOM   4219 C  CA  . ILE B 2 113 ? 177.536 171.583 113.661 1.00 103.90 ? 104 ILE A CA  1 
ATOM   4220 C  C   . ILE B 2 113 ? 178.133 171.544 112.262 1.00 104.17 ? 104 ILE A C   1 
ATOM   4221 O  O   . ILE B 2 113 ? 178.158 172.564 111.565 1.00 103.63 ? 104 ILE A O   1 
ATOM   4222 C  CB  . ILE B 2 113 ? 178.651 171.706 114.722 1.00 105.96 ? 104 ILE A CB  1 
ATOM   4223 C  CG1 . ILE B 2 113 ? 178.068 172.195 116.045 1.00 101.10 ? 104 ILE A CG1 1 
ATOM   4224 C  CG2 . ILE B 2 113 ? 179.748 172.649 114.255 1.00 102.73 ? 104 ILE A CG2 1 
ATOM   4225 C  CD1 . ILE B 2 113 ? 177.445 173.561 115.957 1.00 95.52  ? 104 ILE A CD1 1 
ATOM   4226 N  N   . SER B 2 114 ? 178.604 170.372 111.830 1.00 103.81 ? 105 SER A N   1 
ATOM   4227 C  CA  . SER B 2 114 ? 179.501 170.202 110.691 1.00 105.76 ? 105 SER A CA  1 
ATOM   4228 C  C   . SER B 2 114 ? 179.136 171.025 109.461 1.00 105.36 ? 105 SER A C   1 
ATOM   4229 O  O   . SER B 2 114 ? 179.913 171.890 109.044 1.00 107.67 ? 105 SER A O   1 
ATOM   4230 C  CB  . SER B 2 114 ? 179.562 168.722 110.313 1.00 110.46 ? 105 SER A CB  1 
ATOM   4231 O  OG  . SER B 2 114 ? 179.659 167.912 111.471 1.00 115.77 ? 105 SER A OG  1 
ATOM   4232 N  N   . ASN B 2 115 ? 177.972 170.779 108.872 1.00 103.50 ? 106 ASN A N   1 
ATOM   4233 C  CA  . ASN B 2 115 ? 177.576 171.441 107.633 1.00 102.93 ? 106 ASN A CA  1 
ATOM   4234 C  C   . ASN B 2 115 ? 176.324 172.271 107.884 1.00 97.99  ? 106 ASN A C   1 
ATOM   4235 O  O   . ASN B 2 115 ? 175.215 171.730 107.931 1.00 95.70  ? 106 ASN A O   1 
ATOM   4236 C  CB  . ASN B 2 115 ? 177.335 170.423 106.523 1.00 105.91 ? 106 ASN A CB  1 
ATOM   4237 C  CG  . ASN B 2 115 ? 176.617 171.026 105.337 1.00 102.81 ? 106 ASN A CG  1 
ATOM   4238 O  OD1 . ASN B 2 115 ? 175.474 170.678 105.045 1.00 99.63  ? 106 ASN A OD1 1 
ATOM   4239 N  ND2 . ASN B 2 115 ? 177.284 171.942 104.647 1.00 94.99  ? 106 ASN A ND2 1 
ATOM   4240 N  N   . ASN B 2 116 ? 176.501 173.587 108.024 1.00 94.47  ? 107 ASN A N   1 
ATOM   4241 C  CA  . ASN B 2 116 ? 175.370 174.485 108.228 1.00 91.37  ? 107 ASN A CA  1 
ATOM   4242 C  C   . ASN B 2 116 ? 175.499 175.759 107.397 1.00 91.69  ? 107 ASN A C   1 
ATOM   4243 O  O   . ASN B 2 116 ? 174.886 176.776 107.739 1.00 88.81  ? 107 ASN A O   1 
ATOM   4244 C  CB  . ASN B 2 116 ? 175.207 174.854 109.708 1.00 90.71  ? 107 ASN A CB  1 
ATOM   4245 C  CG  . ASN B 2 116 ? 176.511 175.287 110.363 1.00 98.05  ? 107 ASN A CG  1 
ATOM   4246 O  OD1 . ASN B 2 116 ? 177.574 175.285 109.744 1.00 96.81  ? 107 ASN A OD1 1 
ATOM   4247 N  ND2 . ASN B 2 116 ? 176.427 175.663 111.633 1.00 95.38  ? 107 ASN A ND2 1 
ATOM   4248 N  N   . VAL B 2 117 ? 176.282 175.729 106.317 1.00 88.52  ? 108 VAL A N   1 
ATOM   4249 C  CA  . VAL B 2 117 ? 176.457 176.862 105.417 1.00 75.69  ? 108 VAL A CA  1 
ATOM   4250 C  C   . VAL B 2 117 ? 175.943 176.542 104.019 1.00 73.55  ? 108 VAL A C   1 
ATOM   4251 O  O   . VAL B 2 117 ? 175.194 177.325 103.423 1.00 76.50  ? 108 VAL A O   1 
ATOM   4252 C  CB  . VAL B 2 117 ? 177.934 177.305 105.361 1.00 75.74  ? 108 VAL A CB  1 
ATOM   4253 C  CG1 . VAL B 2 117 ? 178.119 178.402 104.336 1.00 77.00  ? 108 VAL A CG1 1 
ATOM   4254 C  CG2 . VAL B 2 117 ? 178.397 177.763 106.729 1.00 73.69  ? 108 VAL A CG2 1 
ATOM   4255 N  N   . GLN B 2 118 ? 176.345 175.398 103.475 1.00 74.35  ? 109 GLN A N   1 
ATOM   4256 C  CA  . GLN B 2 118 ? 175.852 174.985 102.167 1.00 75.63  ? 109 GLN A CA  1 
ATOM   4257 C  C   . GLN B 2 118 ? 174.335 174.888 102.095 1.00 76.40  ? 109 GLN A C   1 
ATOM   4258 O  O   . GLN B 2 118 ? 173.775 175.290 101.062 1.00 78.48  ? 109 GLN A O   1 
ATOM   4259 C  CB  . GLN B 2 118 ? 176.492 173.652 101.765 1.00 78.71  ? 109 GLN A CB  1 
ATOM   4260 C  CG  . GLN B 2 118 ? 176.293 173.296 100.307 1.00 86.21  ? 109 GLN A CG  1 
ATOM   4261 C  CD  . GLN B 2 118 ? 175.099 172.402 100.089 1.00 87.37  ? 109 GLN A CD  1 
ATOM   4262 O  OE1 . GLN B 2 118 ? 174.956 171.369 100.740 1.00 89.82  ? 109 GLN A OE1 1 
ATOM   4263 N  NE2 . GLN B 2 118 ? 174.233 172.789 99.163  1.00 85.51  ? 109 GLN A NE2 1 
ATOM   4264 N  N   . PRO B 2 119 ? 173.621 174.342 103.087 1.00 74.69  ? 110 PRO A N   1 
ATOM   4265 C  CA  . PRO B 2 119 ? 172.153 174.349 102.991 1.00 72.07  ? 110 PRO A CA  1 
ATOM   4266 C  C   . PRO B 2 119 ? 171.560 175.737 102.840 1.00 72.02  ? 110 PRO A C   1 
ATOM   4267 O  O   . PRO B 2 119 ? 170.636 175.927 102.041 1.00 74.44  ? 110 PRO A O   1 
ATOM   4268 C  CB  . PRO B 2 119 ? 171.726 173.692 104.306 1.00 70.44  ? 110 PRO A CB  1 
ATOM   4269 C  CG  . PRO B 2 119 ? 172.845 172.808 104.648 1.00 77.97  ? 110 PRO A CG  1 
ATOM   4270 C  CD  . PRO B 2 119 ? 174.072 173.557 104.249 1.00 79.48  ? 110 PRO A CD  1 
ATOM   4271 N  N   . VAL B 2 120 ? 172.076 176.719 103.578 1.00 67.33  ? 111 VAL A N   1 
ATOM   4272 C  CA  . VAL B 2 120 ? 171.564 178.079 103.459 1.00 64.50  ? 111 VAL A CA  1 
ATOM   4273 C  C   . VAL B 2 120 ? 171.901 178.659 102.093 1.00 69.44  ? 111 VAL A C   1 
ATOM   4274 O  O   . VAL B 2 120 ? 171.061 179.303 101.450 1.00 71.94  ? 111 VAL A O   1 
ATOM   4275 C  CB  . VAL B 2 120 ? 172.112 178.948 104.601 1.00 67.67  ? 111 VAL A CB  1 
ATOM   4276 C  CG1 . VAL B 2 120 ? 172.058 180.411 104.229 1.00 71.62  ? 111 VAL A CG1 1 
ATOM   4277 C  CG2 . VAL B 2 120 ? 171.324 178.691 105.859 1.00 70.18  ? 111 VAL A CG2 1 
ATOM   4278 N  N   . LEU B 2 121 ? 173.131 178.438 101.624 1.00 71.90  ? 112 LEU A N   1 
ATOM   4279 C  CA  . LEU B 2 121 ? 173.503 178.917 100.297 1.00 69.85  ? 112 LEU A CA  1 
ATOM   4280 C  C   . LEU B 2 121 ? 172.614 178.304 99.227  1.00 71.64  ? 112 LEU A C   1 
ATOM   4281 O  O   . LEU B 2 121 ? 172.304 178.948 98.220  1.00 71.10  ? 112 LEU A O   1 
ATOM   4282 C  CB  . LEU B 2 121 ? 174.968 178.599 100.009 1.00 66.55  ? 112 LEU A CB  1 
ATOM   4283 C  CG  . LEU B 2 121 ? 175.990 179.706 100.250 1.00 64.56  ? 112 LEU A CG  1 
ATOM   4284 C  CD1 . LEU B 2 121 ? 177.301 179.343 99.591  1.00 71.15  ? 112 LEU A CD1 1 
ATOM   4285 C  CD2 . LEU B 2 121 ? 175.482 181.032 99.732  1.00 66.48  ? 112 LEU A CD2 1 
ATOM   4286 N  N   . TYR B 2 122 ? 172.198 177.055 99.426  1.00 73.63  ? 113 TYR A N   1 
ATOM   4287 C  CA  . TYR B 2 122 ? 171.375 176.389 98.427  1.00 76.75  ? 113 TYR A CA  1 
ATOM   4288 C  C   . TYR B 2 122 ? 169.935 176.881 98.488  1.00 74.78  ? 113 TYR A C   1 
ATOM   4289 O  O   . TYR B 2 122 ? 169.283 177.036 97.450  1.00 79.15  ? 113 TYR A O   1 
ATOM   4290 C  CB  . TYR B 2 122 ? 171.453 174.876 98.622  1.00 77.42  ? 113 TYR A CB  1 
ATOM   4291 C  CG  . TYR B 2 122 ? 170.391 174.090 97.901  1.00 76.32  ? 113 TYR A CG  1 
ATOM   4292 C  CD1 . TYR B 2 122 ? 170.595 173.670 96.598  1.00 77.85  ? 113 TYR A CD1 1 
ATOM   4293 C  CD2 . TYR B 2 122 ? 169.206 173.738 98.524  1.00 71.84  ? 113 TYR A CD2 1 
ATOM   4294 C  CE1 . TYR B 2 122 ? 169.646 172.948 95.929  1.00 78.23  ? 113 TYR A CE1 1 
ATOM   4295 C  CE2 . TYR B 2 122 ? 168.248 173.012 97.860  1.00 76.19  ? 113 TYR A CE2 1 
ATOM   4296 C  CZ  . TYR B 2 122 ? 168.475 172.620 96.562  1.00 81.27  ? 113 TYR A CZ  1 
ATOM   4297 O  OH  . TYR B 2 122 ? 167.529 171.894 95.885  1.00 88.54  ? 113 TYR A OH  1 
ATOM   4298 N  N   . PHE B 2 123 ? 169.420 177.126 99.694  1.00 69.95  ? 114 PHE A N   1 
ATOM   4299 C  CA  . PHE B 2 123 ? 168.076 177.681 99.820  1.00 68.91  ? 114 PHE A CA  1 
ATOM   4300 C  C   . PHE B 2 123 ? 167.992 179.066 99.200  1.00 71.40  ? 114 PHE A C   1 
ATOM   4301 O  O   . PHE B 2 123 ? 167.015 179.391 98.518  1.00 75.12  ? 114 PHE A O   1 
ATOM   4302 C  CB  . PHE B 2 123 ? 167.658 177.746 101.287 1.00 65.77  ? 114 PHE A CB  1 
ATOM   4303 C  CG  . PHE B 2 123 ? 167.280 176.423 101.868 1.00 62.25  ? 114 PHE A CG  1 
ATOM   4304 C  CD1 . PHE B 2 123 ? 166.842 175.399 101.057 1.00 64.23  ? 114 PHE A CD1 1 
ATOM   4305 C  CD2 . PHE B 2 123 ? 167.364 176.204 103.225 1.00 56.52  ? 114 PHE A CD2 1 
ATOM   4306 C  CE1 . PHE B 2 123 ? 166.497 174.185 101.591 1.00 62.27  ? 114 PHE A CE1 1 
ATOM   4307 C  CE2 . PHE B 2 123 ? 167.021 174.992 103.760 1.00 56.92  ? 114 PHE A CE2 1 
ATOM   4308 C  CZ  . PHE B 2 123 ? 166.588 173.981 102.943 1.00 59.62  ? 114 PHE A CZ  1 
ATOM   4309 N  N   . LEU B 2 124 ? 169.006 179.899 99.428  1.00 69.99  ? 115 LEU A N   1 
ATOM   4310 C  CA  . LEU B 2 124 ? 168.948 181.269 98.939  1.00 73.01  ? 115 LEU A CA  1 
ATOM   4311 C  C   . LEU B 2 124 ? 169.117 181.365 97.429  1.00 77.12  ? 115 LEU A C   1 
ATOM   4312 O  O   . LEU B 2 124 ? 168.675 182.353 96.835  1.00 78.61  ? 115 LEU A O   1 
ATOM   4313 C  CB  . LEU B 2 124 ? 170.012 182.112 99.633  1.00 76.70  ? 115 LEU A CB  1 
ATOM   4314 C  CG  . LEU B 2 124 ? 169.723 182.416 101.097 1.00 73.08  ? 115 LEU A CG  1 
ATOM   4315 C  CD1 . LEU B 2 124 ? 170.976 182.898 101.788 1.00 73.44  ? 115 LEU A CD1 1 
ATOM   4316 C  CD2 . LEU B 2 124 ? 168.625 183.451 101.189 1.00 72.92  ? 115 LEU A CD2 1 
ATOM   4317 N  N   . ALA B 2 125 ? 169.738 180.374 96.797  1.00 79.08  ? 116 ALA A N   1 
ATOM   4318 C  CA  . ALA B 2 125 ? 169.995 180.445 95.369  1.00 83.50  ? 116 ALA A CA  1 
ATOM   4319 C  C   . ALA B 2 125 ? 168.701 180.262 94.580  1.00 87.90  ? 116 ALA A C   1 
ATOM   4320 O  O   . ALA B 2 125 ? 167.668 179.846 95.107  1.00 89.75  ? 116 ALA A O   1 
ATOM   4321 C  CB  . ALA B 2 125 ? 171.021 179.392 94.956  1.00 82.34  ? 116 ALA A CB  1 
ATOM   4322 N  N   . HIS B 2 126 ? 168.768 180.588 93.293  1.00 89.86  ? 117 HIS A N   1 
ATOM   4323 C  CA  . HIS B 2 126 ? 167.632 180.424 92.397  1.00 92.37  ? 117 HIS A CA  1 
ATOM   4324 C  C   . HIS B 2 126 ? 167.522 178.968 91.956  1.00 95.43  ? 117 HIS A C   1 
ATOM   4325 O  O   . HIS B 2 126 ? 168.161 178.070 92.509  1.00 92.62  ? 117 HIS A O   1 
ATOM   4326 C  CB  . HIS B 2 126 ? 167.761 181.354 91.198  1.00 92.23  ? 117 HIS A CB  1 
ATOM   4327 C  CG  . HIS B 2 126 ? 166.876 182.555 91.270  1.00 96.82  ? 117 HIS A CG  1 
ATOM   4328 N  ND1 . HIS B 2 126 ? 165.502 182.467 91.228  1.00 102.15 ? 117 HIS A ND1 1 
ATOM   4329 C  CD2 . HIS B 2 126 ? 167.166 183.873 91.366  1.00 100.47 ? 117 HIS A CD2 1 
ATOM   4330 C  CE1 . HIS B 2 126 ? 164.983 183.679 91.304  1.00 101.60 ? 117 HIS A CE1 1 
ATOM   4331 N  NE2 . HIS B 2 126 ? 165.972 184.550 91.388  1.00 102.58 ? 117 HIS A NE2 1 
ATOM   4332 N  N   . GLU B 2 127 ? 166.691 178.720 90.943  1.00 98.42  ? 118 GLU A N   1 
ATOM   4333 C  CA  . GLU B 2 127 ? 166.584 177.387 90.366  1.00 102.08 ? 118 GLU A CA  1 
ATOM   4334 C  C   . GLU B 2 127 ? 167.793 177.018 89.517  1.00 100.62 ? 118 GLU A C   1 
ATOM   4335 O  O   . GLU B 2 127 ? 167.937 175.847 89.152  1.00 100.42 ? 118 GLU A O   1 
ATOM   4336 C  CB  . GLU B 2 127 ? 165.311 177.279 89.526  1.00 103.55 ? 118 GLU A CB  1 
ATOM   4337 C  CG  . GLU B 2 127 ? 164.068 177.801 90.225  1.00 105.03 ? 118 GLU A CG  1 
ATOM   4338 C  CD  . GLU B 2 127 ? 163.449 176.780 91.155  1.00 112.84 ? 118 GLU A CD  1 
ATOM   4339 O  OE1 . GLU B 2 127 ? 163.826 175.593 91.075  1.00 112.05 ? 118 GLU A OE1 1 
ATOM   4340 O  OE2 . GLU B 2 127 ? 162.584 177.165 91.968  1.00 113.21 ? 118 GLU A OE2 1 
ATOM   4341 N  N   . ASP B 2 128 ? 168.654 177.980 89.190  1.00 95.67  ? 119 ASP A N   1 
ATOM   4342 C  CA  . ASP B 2 128 ? 169.875 177.717 88.444  1.00 93.08  ? 119 ASP A CA  1 
ATOM   4343 C  C   . ASP B 2 128 ? 171.092 177.592 89.347  1.00 91.79  ? 119 ASP A C   1 
ATOM   4344 O  O   . ASP B 2 128 ? 172.219 177.549 88.846  1.00 92.58  ? 119 ASP A O   1 
ATOM   4345 C  CB  . ASP B 2 128 ? 170.110 178.809 87.398  1.00 94.53  ? 119 ASP A CB  1 
ATOM   4346 C  CG  . ASP B 2 128 ? 170.151 180.203 87.996  1.00 95.31  ? 119 ASP A CG  1 
ATOM   4347 O  OD1 . ASP B 2 128 ? 170.205 180.335 89.235  1.00 95.63  ? 119 ASP A OD1 1 
ATOM   4348 O  OD2 . ASP B 2 128 ? 170.136 181.177 87.216  1.00 99.09  ? 119 ASP A OD2 1 
ATOM   4349 N  N   . ASN B 2 129 ? 170.886 177.547 90.662  1.00 93.41  ? 120 ASN A N   1 
ATOM   4350 C  CA  . ASN B 2 129 ? 171.968 177.403 91.635  1.00 94.32  ? 120 ASN A CA  1 
ATOM   4351 C  C   . ASN B 2 129 ? 172.953 178.567 91.563  1.00 91.31  ? 120 ASN A C   1 
ATOM   4352 O  O   . ASN B 2 129 ? 174.161 178.392 91.729  1.00 88.78  ? 120 ASN A O   1 
ATOM   4353 C  CB  . ASN B 2 129 ? 172.692 176.068 91.462  1.00 98.12  ? 120 ASN A CB  1 
ATOM   4354 C  CG  . ASN B 2 129 ? 173.154 175.491 92.775  1.00 99.85  ? 120 ASN A CG  1 
ATOM   4355 O  OD1 . ASN B 2 129 ? 173.727 176.198 93.601  1.00 100.00 ? 120 ASN A OD1 1 
ATOM   4356 N  ND2 . ASN B 2 129 ? 172.900 174.204 92.983  1.00 97.69  ? 120 ASN A ND2 1 
ATOM   4357 N  N   . LEU B 2 130 ? 172.434 179.766 91.320  1.00 92.49  ? 121 LEU A N   1 
ATOM   4358 C  CA  . LEU B 2 130 ? 173.232 180.984 91.304  1.00 89.10  ? 121 LEU A CA  1 
ATOM   4359 C  C   . LEU B 2 130 ? 172.599 181.998 92.243  1.00 89.03  ? 121 LEU A C   1 
ATOM   4360 O  O   . LEU B 2 130 ? 171.392 182.245 92.169  1.00 92.45  ? 121 LEU A O   1 
ATOM   4361 C  CB  . LEU B 2 130 ? 173.335 181.564 89.891  1.00 89.64  ? 121 LEU A CB  1 
ATOM   4362 C  CG  . LEU B 2 130 ? 174.463 181.043 89.002  1.00 85.13  ? 121 LEU A CG  1 
ATOM   4363 C  CD1 . LEU B 2 130 ? 174.752 182.026 87.882  1.00 82.81  ? 121 LEU A CD1 1 
ATOM   4364 C  CD2 . LEU B 2 130 ? 175.708 180.792 89.820  1.00 81.98  ? 121 LEU A CD2 1 
ATOM   4365 N  N   . LEU B 2 131 ? 173.410 182.586 93.117  1.00 87.36  ? 122 LEU A N   1 
ATOM   4366 C  CA  . LEU B 2 131 ? 172.924 183.565 94.082  1.00 87.99  ? 122 LEU A CA  1 
ATOM   4367 C  C   . LEU B 2 131 ? 173.449 184.942 93.712  1.00 91.71  ? 122 LEU A C   1 
ATOM   4368 O  O   . LEU B 2 131 ? 174.637 185.228 93.922  1.00 96.27  ? 122 LEU A O   1 
ATOM   4369 C  CB  . LEU B 2 131 ? 173.360 183.188 95.500  1.00 85.16  ? 122 LEU A CB  1 
ATOM   4370 C  CG  . LEU B 2 131 ? 173.107 184.223 96.595  1.00 83.60  ? 122 LEU A CG  1 
ATOM   4371 C  CD1 . LEU B 2 131 ? 171.635 184.544 96.684  1.00 84.93  ? 122 LEU A CD1 1 
ATOM   4372 C  CD2 . LEU B 2 131 ? 173.624 183.721 97.928  1.00 77.26  ? 122 LEU A CD2 1 
ATOM   4373 N  N   . PRO B 2 132 ? 172.625 185.823 93.155  1.00 91.22  ? 123 PRO A N   1 
ATOM   4374 C  CA  . PRO B 2 132 ? 173.108 187.162 92.813  1.00 91.64  ? 123 PRO A CA  1 
ATOM   4375 C  C   . PRO B 2 132 ? 173.447 187.960 94.058  1.00 90.98  ? 123 PRO A C   1 
ATOM   4376 O  O   . PRO B 2 132 ? 172.886 187.746 95.134  1.00 88.16  ? 123 PRO A O   1 
ATOM   4377 C  CB  . PRO B 2 132 ? 171.929 187.785 92.060  1.00 91.26  ? 123 PRO A CB  1 
ATOM   4378 C  CG  . PRO B 2 132 ? 170.739 187.041 92.549  1.00 90.78  ? 123 PRO A CG  1 
ATOM   4379 C  CD  . PRO B 2 132 ? 171.205 185.641 92.817  1.00 89.91  ? 123 PRO A CD  1 
ATOM   4380 N  N   . ILE B 2 133 ? 174.384 188.889 93.900  1.00 94.01  ? 124 ILE A N   1 
ATOM   4381 C  CA  . ILE B 2 133 ? 174.784 189.800 94.965  1.00 95.33  ? 124 ILE A CA  1 
ATOM   4382 C  C   . ILE B 2 133 ? 174.393 191.208 94.550  1.00 99.01  ? 124 ILE A C   1 
ATOM   4383 O  O   . ILE B 2 133 ? 174.794 191.684 93.481  1.00 101.83 ? 124 ILE A O   1 
ATOM   4384 C  CB  . ILE B 2 133 ? 176.287 189.714 95.258  1.00 93.88  ? 124 ILE A CB  1 
ATOM   4385 C  CG1 . ILE B 2 133 ? 176.680 188.271 95.549  1.00 89.74  ? 124 ILE A CG1 1 
ATOM   4386 C  CG2 . ILE B 2 133 ? 176.639 190.608 96.429  1.00 89.43  ? 124 ILE A CG2 1 
ATOM   4387 C  CD1 . ILE B 2 133 ? 176.096 187.751 96.827  1.00 84.69  ? 124 ILE A CD1 1 
ATOM   4388 N  N   . GLN B 2 134 ? 173.617 191.875 95.397  1.00 95.50  ? 125 GLN A N   1 
ATOM   4389 C  CA  . GLN B 2 134 ? 173.146 193.216 95.100  1.00 96.00  ? 125 GLN A CA  1 
ATOM   4390 C  C   . GLN B 2 134 ? 172.987 193.976 96.405  1.00 96.01  ? 125 GLN A C   1 
ATOM   4391 O  O   . GLN B 2 134 ? 172.941 193.388 97.488  1.00 94.10  ? 125 GLN A O   1 
ATOM   4392 C  CB  . GLN B 2 134 ? 171.825 193.193 94.326  1.00 96.17  ? 125 GLN A CB  1 
ATOM   4393 C  CG  . GLN B 2 134 ? 170.962 191.978 94.606  1.00 94.77  ? 125 GLN A CG  1 
ATOM   4394 C  CD  . GLN B 2 134 ? 169.847 191.817 93.599  1.00 94.69  ? 125 GLN A CD  1 
ATOM   4395 O  OE1 . GLN B 2 134 ? 170.090 191.708 92.400  1.00 94.54  ? 125 GLN A OE1 1 
ATOM   4396 N  NE2 . GLN B 2 134 ? 168.613 191.807 94.082  1.00 91.60  ? 125 GLN A NE2 1 
ATOM   4397 N  N   . GLU B 2 135 ? 172.919 195.300 96.289  1.00 97.11  ? 126 GLU A N   1 
ATOM   4398 C  CA  . GLU B 2 135 ? 172.750 196.132 97.473  1.00 98.22  ? 126 GLU A CA  1 
ATOM   4399 C  C   . GLU B 2 135 ? 171.398 195.893 98.135  1.00 99.21  ? 126 GLU A C   1 
ATOM   4400 O  O   . GLU B 2 135 ? 171.303 195.868 99.367  1.00 101.82 ? 126 GLU A O   1 
ATOM   4401 C  CB  . GLU B 2 135 ? 172.921 197.604 97.104  1.00 99.25  ? 126 GLU A CB  1 
ATOM   4402 C  CG  . GLU B 2 135 ? 174.368 198.028 96.890  1.00 97.44  ? 126 GLU A CG  1 
ATOM   4403 C  CD  . GLU B 2 135 ? 174.902 197.629 95.527  1.00 98.94  ? 126 GLU A CD  1 
ATOM   4404 O  OE1 . GLU B 2 135 ? 174.086 197.388 94.614  1.00 99.70  ? 126 GLU A OE1 1 
ATOM   4405 O  OE2 . GLU B 2 135 ? 176.139 197.558 95.366  1.00 96.52  ? 126 GLU A OE2 1 
ATOM   4406 N  N   . ASP B 2 136 ? 170.344 195.715 97.342  1.00 97.27  ? 127 ASP A N   1 
ATOM   4407 C  CA  . ASP B 2 136 ? 168.990 195.565 97.856  1.00 94.31  ? 127 ASP A CA  1 
ATOM   4408 C  C   . ASP B 2 136 ? 168.390 194.245 97.398  1.00 87.71  ? 127 ASP A C   1 
ATOM   4409 O  O   . ASP B 2 136 ? 168.532 193.857 96.235  1.00 86.35  ? 127 ASP A O   1 
ATOM   4410 C  CB  . ASP B 2 136 ? 168.098 196.721 97.400  1.00 99.78  ? 127 ASP A CB  1 
ATOM   4411 C  CG  . ASP B 2 136 ? 167.087 197.124 98.452  1.00 102.09 ? 127 ASP A CG  1 
ATOM   4412 O  OD1 . ASP B 2 136 ? 167.156 196.586 99.574  1.00 98.97  ? 127 ASP A OD1 1 
ATOM   4413 O  OD2 . ASP B 2 136 ? 166.225 197.979 98.159  1.00 105.30 ? 127 ASP A OD2 1 
ATOM   4414 N  N   . TYR B 2 137 ? 167.709 193.564 98.319  1.00 85.96  ? 128 TYR A N   1 
ATOM   4415 C  CA  . TYR B 2 137 ? 167.063 192.288 98.044  1.00 89.45  ? 128 TYR A CA  1 
ATOM   4416 C  C   . TYR B 2 137 ? 165.543 192.377 98.118  1.00 92.28  ? 128 TYR A C   1 
ATOM   4417 O  O   . TYR B 2 137 ? 164.878 191.353 98.299  1.00 93.11  ? 128 TYR A O   1 
ATOM   4418 C  CB  . TYR B 2 137 ? 167.569 191.218 99.009  1.00 89.82  ? 128 TYR A CB  1 
ATOM   4419 C  CG  . TYR B 2 137 ? 168.919 190.653 98.652  1.00 93.73  ? 128 TYR A CG  1 
ATOM   4420 C  CD1 . TYR B 2 137 ? 169.102 189.924 97.488  1.00 91.26  ? 128 TYR A CD1 1 
ATOM   4421 C  CD2 . TYR B 2 137 ? 170.012 190.846 99.480  1.00 94.96  ? 128 TYR A CD2 1 
ATOM   4422 C  CE1 . TYR B 2 137 ? 170.335 189.407 97.158  1.00 89.36  ? 128 TYR A CE1 1 
ATOM   4423 C  CE2 . TYR B 2 137 ? 171.249 190.332 99.159  1.00 95.37  ? 128 TYR A CE2 1 
ATOM   4424 C  CZ  . TYR B 2 137 ? 171.404 189.615 97.997  1.00 92.84  ? 128 TYR A CZ  1 
ATOM   4425 O  OH  . TYR B 2 137 ? 172.636 189.102 97.677  1.00 93.66  ? 128 TYR A OH  1 
ATOM   4426 N  N   . SER B 2 138 ? 164.980 193.580 97.987  1.00 92.74  ? 129 SER A N   1 
ATOM   4427 C  CA  . SER B 2 138 ? 163.534 193.734 98.105  1.00 90.62  ? 129 SER A CA  1 
ATOM   4428 C  C   . SER B 2 138 ? 162.803 192.966 97.013  1.00 90.32  ? 129 SER A C   1 
ATOM   4429 O  O   . SER B 2 138 ? 161.786 192.314 97.277  1.00 89.66  ? 129 SER A O   1 
ATOM   4430 C  CB  . SER B 2 138 ? 163.156 195.212 98.058  1.00 89.86  ? 129 SER A CB  1 
ATOM   4431 O  OG  . SER B 2 138 ? 163.777 195.929 99.108  1.00 89.45  ? 129 SER A OG  1 
ATOM   4432 N  N   . ASN B 2 139 ? 163.301 193.029 95.784  1.00 91.70  ? 130 ASN A N   1 
ATOM   4433 C  CA  . ASN B 2 139 ? 162.660 192.372 94.654  1.00 94.59  ? 130 ASN A CA  1 
ATOM   4434 C  C   . ASN B 2 139 ? 163.147 190.947 94.433  1.00 94.32  ? 130 ASN A C   1 
ATOM   4435 O  O   . ASN B 2 139 ? 162.610 190.255 93.564  1.00 94.66  ? 130 ASN A O   1 
ATOM   4436 C  CB  . ASN B 2 139 ? 162.877 193.191 93.379  1.00 101.11 ? 130 ASN A CB  1 
ATOM   4437 C  CG  . ASN B 2 139 ? 164.328 193.585 93.179  1.00 106.05 ? 130 ASN A CG  1 
ATOM   4438 O  OD1 . ASN B 2 139 ? 165.234 192.770 93.343  1.00 104.78 ? 130 ASN A OD1 1 
ATOM   4439 N  ND2 . ASN B 2 139 ? 164.554 194.843 92.823  1.00 105.85 ? 130 ASN A ND2 1 
ATOM   4440 N  N   . TYR B 2 140 ? 164.143 190.494 95.187  1.00 91.18  ? 131 TYR A N   1 
ATOM   4441 C  CA  . TYR B 2 140 ? 164.685 189.157 94.994  1.00 89.39  ? 131 TYR A CA  1 
ATOM   4442 C  C   . TYR B 2 140 ? 163.723 188.109 95.534  1.00 88.70  ? 131 TYR A C   1 
ATOM   4443 O  O   . TYR B 2 140 ? 163.219 188.234 96.654  1.00 86.53  ? 131 TYR A O   1 
ATOM   4444 C  CB  . TYR B 2 140 ? 166.040 189.025 95.684  1.00 90.27  ? 131 TYR A CB  1 
ATOM   4445 C  CG  . TYR B 2 140 ? 166.717 187.701 95.427  1.00 89.11  ? 131 TYR A CG  1 
ATOM   4446 C  CD1 . TYR B 2 140 ? 166.953 187.263 94.136  1.00 87.24  ? 131 TYR A CD1 1 
ATOM   4447 C  CD2 . TYR B 2 140 ? 167.114 186.886 96.476  1.00 86.18  ? 131 TYR A CD2 1 
ATOM   4448 C  CE1 . TYR B 2 140 ? 167.567 186.057 93.897  1.00 85.37  ? 131 TYR A CE1 1 
ATOM   4449 C  CE2 . TYR B 2 140 ? 167.729 185.676 96.245  1.00 83.67  ? 131 TYR A CE2 1 
ATOM   4450 C  CZ  . TYR B 2 140 ? 167.951 185.268 94.954  1.00 84.01  ? 131 TYR A CZ  1 
ATOM   4451 O  OH  . TYR B 2 140 ? 168.564 184.064 94.711  1.00 85.19  ? 131 TYR A OH  1 
ATOM   4452 N  N   . ILE B 2 141 ? 163.475 187.074 94.738  1.00 87.55  ? 132 ILE A N   1 
ATOM   4453 C  CA  . ILE B 2 141 ? 162.662 185.933 95.140  1.00 83.18  ? 132 ILE A CA  1 
ATOM   4454 C  C   . ILE B 2 141 ? 163.568 184.711 95.190  1.00 81.95  ? 132 ILE A C   1 
ATOM   4455 O  O   . ILE B 2 141 ? 164.259 184.397 94.214  1.00 83.87  ? 132 ILE A O   1 
ATOM   4456 C  CB  . ILE B 2 141 ? 161.473 185.714 94.193  1.00 81.79  ? 132 ILE A CB  1 
ATOM   4457 C  CG1 . ILE B 2 141 ? 160.745 184.418 94.546  1.00 87.10  ? 132 ILE A CG1 1 
ATOM   4458 C  CG2 . ILE B 2 141 ? 161.917 185.718 92.741  1.00 78.75  ? 132 ILE A CG2 1 
ATOM   4459 C  CD1 . ILE B 2 141 ? 159.422 184.254 93.843  1.00 88.80  ? 132 ILE A CD1 1 
ATOM   4460 N  N   . SER B 2 142 ? 163.574 184.029 96.329  1.00 79.84  ? 133 SER A N   1 
ATOM   4461 C  CA  . SER B 2 142 ? 164.482 182.919 96.552  1.00 80.31  ? 133 SER A CA  1 
ATOM   4462 C  C   . SER B 2 142 ? 163.801 181.596 96.218  1.00 80.96  ? 133 SER A C   1 
ATOM   4463 O  O   . SER B 2 142 ? 162.617 181.542 95.882  1.00 84.42  ? 133 SER A O   1 
ATOM   4464 C  CB  . SER B 2 142 ? 164.981 182.932 97.992  1.00 78.58  ? 133 SER A CB  1 
ATOM   4465 O  OG  . SER B 2 142 ? 163.911 183.181 98.883  1.00 80.20  ? 133 SER A OG  1 
ATOM   4466 N  N   . ARG B 2 143 ? 164.570 180.510 96.301  1.00 77.96  ? 134 ARG A N   1 
ATOM   4467 C  CA  . ARG B 2 143 ? 164.015 179.193 96.013  1.00 75.95  ? 134 ARG A CA  1 
ATOM   4468 C  C   . ARG B 2 143 ? 162.949 178.806 97.028  1.00 72.23  ? 134 ARG A C   1 
ATOM   4469 O  O   . ARG B 2 143 ? 161.916 178.235 96.663  1.00 74.24  ? 134 ARG A O   1 
ATOM   4470 C  CB  . ARG B 2 143 ? 165.126 178.147 95.984  1.00 75.56  ? 134 ARG A CB  1 
ATOM   4471 C  CG  . ARG B 2 143 ? 164.629 176.736 95.744  1.00 76.13  ? 134 ARG A CG  1 
ATOM   4472 C  CD  . ARG B 2 143 ? 165.589 175.711 96.305  1.00 75.64  ? 134 ARG A CD  1 
ATOM   4473 N  NE  . ARG B 2 143 ? 166.899 175.795 95.679  1.00 79.20  ? 134 ARG A NE  1 
ATOM   4474 C  CZ  . ARG B 2 143 ? 167.230 175.171 94.558  1.00 80.75  ? 134 ARG A CZ  1 
ATOM   4475 N  NH1 . ARG B 2 143 ? 166.366 174.403 93.916  1.00 78.34  ? 134 ARG A NH1 1 
ATOM   4476 N  NH2 . ARG B 2 143 ? 168.456 175.322 94.069  1.00 81.03  ? 134 ARG A NH2 1 
ATOM   4477 N  N   . VAL B 2 144 ? 163.179 179.106 98.302  1.00 63.32  ? 135 VAL A N   1 
ATOM   4478 C  CA  . VAL B 2 144 ? 162.265 178.742 99.375  1.00 60.54  ? 135 VAL A CA  1 
ATOM   4479 C  C   . VAL B 2 144 ? 161.717 180.011 100.009 1.00 68.18  ? 135 VAL A C   1 
ATOM   4480 O  O   . VAL B 2 144 ? 162.421 181.020 100.116 1.00 72.16  ? 135 VAL A O   1 
ATOM   4481 C  CB  . VAL B 2 144 ? 162.957 177.853 100.425 1.00 58.82  ? 135 VAL A CB  1 
ATOM   4482 C  CG1 . VAL B 2 144 ? 163.545 176.637 99.759  1.00 65.33  ? 135 VAL A CG1 1 
ATOM   4483 C  CG2 . VAL B 2 144 ? 164.045 178.621 101.131 1.00 62.12  ? 135 VAL A CG2 1 
ATOM   4484 N  N   . VAL B 2 145 ? 160.448 179.962 100.412 1.00 72.12  ? 136 VAL A N   1 
ATOM   4485 C  CA  . VAL B 2 145 ? 159.800 181.124 101.009 1.00 69.94  ? 136 VAL A CA  1 
ATOM   4486 C  C   . VAL B 2 145 ? 160.022 181.216 102.513 1.00 65.43  ? 136 VAL A C   1 
ATOM   4487 O  O   . VAL B 2 145 ? 159.831 182.293 103.093 1.00 68.33  ? 136 VAL A O   1 
ATOM   4488 C  CB  . VAL B 2 145 ? 158.293 181.113 100.700 1.00 67.74  ? 136 VAL A CB  1 
ATOM   4489 C  CG1 . VAL B 2 145 ? 157.554 180.225 101.678 1.00 64.66  ? 136 VAL A CG1 1 
ATOM   4490 C  CG2 . VAL B 2 145 ? 157.739 182.518 100.729 1.00 69.31  ? 136 VAL A CG2 1 
ATOM   4491 N  N   . ALA B 2 146 ? 160.411 180.122 103.159 1.00 60.49  ? 137 ALA A N   1 
ATOM   4492 C  CA  . ALA B 2 146 ? 160.721 180.109 104.579 1.00 53.21  ? 137 ALA A CA  1 
ATOM   4493 C  C   . ALA B 2 146 ? 161.529 178.855 104.859 1.00 53.58  ? 137 ALA A C   1 
ATOM   4494 O  O   . ALA B 2 146 ? 161.580 177.940 104.037 1.00 63.56  ? 137 ALA A O   1 
ATOM   4495 C  CB  . ALA B 2 146 ? 159.457 180.146 105.439 1.00 54.50  ? 137 ALA A CB  1 
ATOM   4496 N  N   . VAL B 2 147 ? 162.166 178.821 106.022 1.00 45.12  ? 138 VAL A N   1 
ATOM   4497 C  CA  . VAL B 2 147 ? 162.997 177.691 106.411 1.00 47.91  ? 138 VAL A CA  1 
ATOM   4498 C  C   . VAL B 2 147 ? 162.655 177.289 107.837 1.00 53.28  ? 138 VAL A C   1 
ATOM   4499 O  O   . VAL B 2 147 ? 162.524 178.148 108.714 1.00 57.51  ? 138 VAL A O   1 
ATOM   4500 C  CB  . VAL B 2 147 ? 164.495 178.019 106.267 1.00 49.03  ? 138 VAL A CB  1 
ATOM   4501 C  CG1 . VAL B 2 147 ? 164.811 179.320 106.936 1.00 52.19  ? 138 VAL A CG1 1 
ATOM   4502 C  CG2 . VAL B 2 147 ? 165.338 176.918 106.865 1.00 54.18  ? 138 VAL A CG2 1 
ATOM   4503 N  N   . ILE B 2 148 ? 162.478 175.990 108.059 1.00 51.19  ? 139 ILE A N   1 
ATOM   4504 C  CA  . ILE B 2 148 ? 162.306 175.449 109.403 1.00 52.35  ? 139 ILE A CA  1 
ATOM   4505 C  C   . ILE B 2 148 ? 163.699 175.193 109.966 1.00 56.27  ? 139 ILE A C   1 
ATOM   4506 O  O   . ILE B 2 148 ? 164.385 174.259 109.548 1.00 58.92  ? 139 ILE A O   1 
ATOM   4507 C  CB  . ILE B 2 148 ? 161.465 174.171 109.393 1.00 51.59  ? 139 ILE A CB  1 
ATOM   4508 C  CG1 . ILE B 2 148 ? 160.223 174.365 108.530 1.00 47.40  ? 139 ILE A CG1 1 
ATOM   4509 C  CG2 . ILE B 2 148 ? 161.061 173.795 110.796 1.00 51.32  ? 139 ILE A CG2 1 
ATOM   4510 C  CD1 . ILE B 2 148 ? 159.357 175.501 108.965 1.00 47.33  ? 139 ILE A CD1 1 
ATOM   4511 N  N   . GLY B 2 149 ? 164.109 176.010 110.929 1.00 59.89  ? 140 GLY A N   1 
ATOM   4512 C  CA  . GLY B 2 149 ? 165.498 176.120 111.305 1.00 61.32  ? 140 GLY A CA  1 
ATOM   4513 C  C   . GLY B 2 149 ? 166.076 174.876 111.938 1.00 64.94  ? 140 GLY A C   1 
ATOM   4514 O  O   . GLY B 2 149 ? 165.377 173.894 112.198 1.00 66.16  ? 140 GLY A O   1 
ATOM   4515 N  N   . PRO B 2 150 ? 167.383 174.895 112.187 1.00 67.90  ? 141 PRO A N   1 
ATOM   4516 C  CA  . PRO B 2 150 ? 168.038 173.743 112.815 1.00 71.19  ? 141 PRO A CA  1 
ATOM   4517 C  C   . PRO B 2 150 ? 167.585 173.527 114.248 1.00 76.49  ? 141 PRO A C   1 
ATOM   4518 O  O   . PRO B 2 150 ? 166.787 174.303 114.781 1.00 76.63  ? 141 PRO A O   1 
ATOM   4519 C  CB  . PRO B 2 150 ? 169.526 174.106 112.746 1.00 71.05  ? 141 PRO A CB  1 
ATOM   4520 C  CG  . PRO B 2 150 ? 169.619 175.138 111.679 1.00 68.47  ? 141 PRO A CG  1 
ATOM   4521 C  CD  . PRO B 2 150 ? 168.354 175.919 111.779 1.00 67.03  ? 141 PRO A CD  1 
ATOM   4522 N  N   . ASP B 2 151 ? 168.103 172.482 114.888 1.00 79.43  ? 142 ASP A N   1 
ATOM   4523 C  CA  . ASP B 2 151 ? 167.605 172.030 116.179 1.00 84.37  ? 142 ASP A CA  1 
ATOM   4524 C  C   . ASP B 2 151 ? 168.498 172.424 117.348 1.00 89.11  ? 142 ASP A C   1 
ATOM   4525 O  O   . ASP B 2 151 ? 168.160 172.124 118.497 1.00 91.69  ? 142 ASP A O   1 
ATOM   4526 C  CB  . ASP B 2 151 ? 167.420 170.515 116.152 1.00 87.72  ? 142 ASP A CB  1 
ATOM   4527 C  CG  . ASP B 2 151 ? 168.272 169.853 115.096 1.00 90.76  ? 142 ASP A CG  1 
ATOM   4528 O  OD1 . ASP B 2 151 ? 169.514 169.935 115.193 1.00 93.82  ? 142 ASP A OD1 1 
ATOM   4529 O  OD2 . ASP B 2 151 ? 167.698 169.257 114.162 1.00 90.16  ? 142 ASP A OD2 1 
ATOM   4530 N  N   . ASN B 2 152 ? 169.621 173.084 117.095 1.00 87.34  ? 143 ASN A N   1 
ATOM   4531 C  CA  . ASN B 2 152 ? 170.516 173.508 118.159 1.00 87.36  ? 143 ASN A CA  1 
ATOM   4532 C  C   . ASN B 2 152 ? 170.826 174.986 118.002 1.00 85.51  ? 143 ASN A C   1 
ATOM   4533 O  O   . ASN B 2 152 ? 170.698 175.551 116.916 1.00 83.36  ? 143 ASN A O   1 
ATOM   4534 C  CB  . ASN B 2 152 ? 171.811 172.696 118.170 1.00 90.91  ? 143 ASN A CB  1 
ATOM   4535 C  CG  . ASN B 2 152 ? 172.600 172.846 116.895 1.00 93.27  ? 143 ASN A CG  1 
ATOM   4536 O  OD1 . ASN B 2 152 ? 173.456 173.721 116.781 1.00 94.60  ? 143 ASN A OD1 1 
ATOM   4537 N  ND2 . ASN B 2 152 ? 172.319 171.988 115.924 1.00 92.39  ? 143 ASN A ND2 1 
ATOM   4538 N  N   . SER B 2 153 ? 171.235 175.607 119.107 1.00 86.23  ? 144 SER A N   1 
ATOM   4539 C  CA  . SER B 2 153 ? 171.403 177.053 119.133 1.00 83.65  ? 144 SER A CA  1 
ATOM   4540 C  C   . SER B 2 153 ? 172.494 177.547 118.194 1.00 84.16  ? 144 SER A C   1 
ATOM   4541 O  O   . SER B 2 153 ? 172.319 178.598 117.574 1.00 85.12  ? 144 SER A O   1 
ATOM   4542 C  CB  . SER B 2 153 ? 171.707 177.522 120.551 1.00 82.60  ? 144 SER A CB  1 
ATOM   4543 O  OG  . SER B 2 153 ? 172.372 178.770 120.527 1.00 84.34  ? 144 SER A OG  1 
ATOM   4544 N  N   . GLU B 2 154 ? 173.614 176.835 118.080 1.00 83.95  ? 145 GLU A N   1 
ATOM   4545 C  CA  . GLU B 2 154 ? 174.744 177.355 117.315 1.00 85.80  ? 145 GLU A CA  1 
ATOM   4546 C  C   . GLU B 2 154 ? 174.455 177.400 115.817 1.00 83.05  ? 145 GLU A C   1 
ATOM   4547 O  O   . GLU B 2 154 ? 174.694 178.422 115.160 1.00 80.35  ? 145 GLU A O   1 
ATOM   4548 C  CB  . GLU B 2 154 ? 175.989 176.517 117.591 1.00 85.38  ? 145 GLU A CB  1 
ATOM   4549 C  CG  . GLU B 2 154 ? 177.301 177.102 117.072 1.00 91.46  ? 145 GLU A CG  1 
ATOM   4550 C  CD  . GLU B 2 154 ? 177.484 178.585 117.371 1.00 92.95  ? 145 GLU A CD  1 
ATOM   4551 O  OE1 . GLU B 2 154 ? 178.344 178.910 118.219 1.00 100.36 ? 145 GLU A OE1 1 
ATOM   4552 O  OE2 . GLU B 2 154 ? 176.825 179.429 116.729 1.00 86.72  ? 145 GLU A OE2 1 
ATOM   4553 N  N   . SER B 2 155 ? 173.952 176.301 115.254 1.00 80.77  ? 146 SER A N   1 
ATOM   4554 C  CA  . SER B 2 155 ? 173.628 176.311 113.834 1.00 77.33  ? 146 SER A CA  1 
ATOM   4555 C  C   . SER B 2 155 ? 172.459 177.239 113.543 1.00 76.41  ? 146 SER A C   1 
ATOM   4556 O  O   . SER B 2 155 ? 172.402 177.838 112.466 1.00 77.92  ? 146 SER A O   1 
ATOM   4557 C  CB  . SER B 2 155 ? 173.322 174.901 113.343 1.00 81.27  ? 146 SER A CB  1 
ATOM   4558 O  OG  . SER B 2 155 ? 172.431 174.248 114.220 1.00 87.28  ? 146 SER A OG  1 
ATOM   4559 N  N   . VAL B 2 156 ? 171.523 177.371 114.484 1.00 75.58  ? 147 VAL A N   1 
ATOM   4560 C  CA  . VAL B 2 156 ? 170.454 178.351 114.325 1.00 69.40  ? 147 VAL A CA  1 
ATOM   4561 C  C   . VAL B 2 156 ? 171.035 179.754 114.253 1.00 70.35  ? 147 VAL A C   1 
ATOM   4562 O  O   . VAL B 2 156 ? 170.609 180.577 113.436 1.00 71.79  ? 147 VAL A O   1 
ATOM   4563 C  CB  . VAL B 2 156 ? 169.432 178.222 115.465 1.00 67.91  ? 147 VAL A CB  1 
ATOM   4564 C  CG1 . VAL B 2 156 ? 168.656 179.503 115.613 1.00 65.78  ? 147 VAL A CG1 1 
ATOM   4565 C  CG2 . VAL B 2 156 ? 168.486 177.082 115.190 1.00 69.46  ? 147 VAL A CG2 1 
ATOM   4566 N  N   . MET B 2 157 ? 172.017 180.048 115.103 1.00 71.96  ? 148 MET A N   1 
ATOM   4567 C  CA  . MET B 2 157 ? 172.662 181.354 115.061 1.00 75.29  ? 148 MET A CA  1 
ATOM   4568 C  C   . MET B 2 157 ? 173.355 181.578 113.726 1.00 73.81  ? 148 MET A C   1 
ATOM   4569 O  O   . MET B 2 157 ? 173.268 182.667 113.150 1.00 73.03  ? 148 MET A O   1 
ATOM   4570 C  CB  . MET B 2 157 ? 173.660 181.483 116.210 1.00 80.43  ? 148 MET A CB  1 
ATOM   4571 C  CG  . MET B 2 157 ? 173.355 182.615 117.172 1.00 82.80  ? 148 MET A CG  1 
ATOM   4572 S  SD  . MET B 2 157 ? 174.502 182.682 118.556 1.00 100.41 ? 148 MET A SD  1 
ATOM   4573 C  CE  . MET B 2 157 ? 173.561 181.844 119.824 1.00 91.18  ? 148 MET A CE  1 
ATOM   4574 N  N   . THR B 2 158 ? 174.045 180.557 113.216 1.00 76.40  ? 149 THR A N   1 
ATOM   4575 C  CA  . THR B 2 158 ? 174.715 180.702 111.925 1.00 75.71  ? 149 THR A CA  1 
ATOM   4576 C  C   . THR B 2 158 ? 173.714 180.949 110.801 1.00 74.07  ? 149 THR A C   1 
ATOM   4577 O  O   . THR B 2 158 ? 173.914 181.834 109.958 1.00 74.66  ? 149 THR A O   1 
ATOM   4578 C  CB  . THR B 2 158 ? 175.551 179.463 111.618 1.00 75.37  ? 149 THR A CB  1 
ATOM   4579 O  OG1 . THR B 2 158 ? 176.285 179.080 112.785 1.00 80.55  ? 149 THR A OG1 1 
ATOM   4580 C  CG2 . THR B 2 158 ? 176.523 179.757 110.497 1.00 72.68  ? 149 THR A CG2 1 
ATOM   4581 N  N   . VAL B 2 159 ? 172.624 180.181 110.780 1.00 70.59  ? 150 VAL A N   1 
ATOM   4582 C  CA  . VAL B 2 159 ? 171.625 180.329 109.727 1.00 66.31  ? 150 VAL A CA  1 
ATOM   4583 C  C   . VAL B 2 159 ? 170.970 181.701 109.802 1.00 68.42  ? 150 VAL A C   1 
ATOM   4584 O  O   . VAL B 2 159 ? 170.740 182.350 108.776 1.00 74.30  ? 150 VAL A O   1 
ATOM   4585 C  CB  . VAL B 2 159 ? 170.588 179.197 109.813 1.00 61.02  ? 150 VAL A CB  1 
ATOM   4586 C  CG1 . VAL B 2 159 ? 169.411 179.488 108.915 1.00 60.88  ? 150 VAL A CG1 1 
ATOM   4587 C  CG2 . VAL B 2 159 ? 171.222 177.877 109.435 1.00 60.27  ? 150 VAL A CG2 1 
ATOM   4588 N  N   . ALA B 2 160 ? 170.653 182.163 111.011 1.00 64.38  ? 151 ALA A N   1 
ATOM   4589 C  CA  . ALA B 2 160 ? 170.052 183.484 111.157 1.00 63.55  ? 151 ALA A CA  1 
ATOM   4590 C  C   . ALA B 2 160 ? 171.018 184.582 110.734 1.00 71.50  ? 151 ALA A C   1 
ATOM   4591 O  O   . ALA B 2 160 ? 170.610 185.563 110.102 1.00 75.73  ? 151 ALA A O   1 
ATOM   4592 C  CB  . ALA B 2 160 ? 169.592 183.693 112.596 1.00 62.98  ? 151 ALA A CB  1 
ATOM   4593 N  N   . ASN B 2 161 ? 172.302 184.442 111.075 1.00 74.51  ? 152 ASN A N   1 
ATOM   4594 C  CA  . ASN B 2 161 ? 173.290 185.423 110.641 1.00 70.59  ? 152 ASN A CA  1 
ATOM   4595 C  C   . ASN B 2 161 ? 173.394 185.469 109.128 1.00 68.82  ? 152 ASN A C   1 
ATOM   4596 O  O   . ASN B 2 161 ? 173.610 186.541 108.553 1.00 70.24  ? 152 ASN A O   1 
ATOM   4597 C  CB  . ASN B 2 161 ? 174.655 185.106 111.247 1.00 69.54  ? 152 ASN A CB  1 
ATOM   4598 C  CG  . ASN B 2 161 ? 174.815 185.661 112.641 1.00 75.28  ? 152 ASN A CG  1 
ATOM   4599 O  OD1 . ASN B 2 161 ? 174.461 186.807 112.910 1.00 76.52  ? 152 ASN A OD1 1 
ATOM   4600 N  ND2 . ASN B 2 161 ? 175.355 184.849 113.541 1.00 74.80  ? 152 ASN A ND2 1 
ATOM   4601 N  N   . PHE B 2 162 ? 173.261 184.322 108.467 1.00 70.45  ? 153 PHE A N   1 
ATOM   4602 C  CA  . PHE B 2 162 ? 173.322 184.303 107.010 1.00 72.35  ? 153 PHE A CA  1 
ATOM   4603 C  C   . PHE B 2 162 ? 172.054 184.830 106.359 1.00 70.16  ? 153 PHE A C   1 
ATOM   4604 O  O   . PHE B 2 162 ? 172.131 185.430 105.284 1.00 72.85  ? 153 PHE A O   1 
ATOM   4605 C  CB  . PHE B 2 162 ? 173.593 182.887 106.506 1.00 73.17  ? 153 PHE A CB  1 
ATOM   4606 C  CG  . PHE B 2 162 ? 174.995 182.418 106.738 1.00 80.59  ? 153 PHE A CG  1 
ATOM   4607 C  CD1 . PHE B 2 162 ? 175.812 183.043 107.662 1.00 84.04  ? 153 PHE A CD1 1 
ATOM   4608 C  CD2 . PHE B 2 162 ? 175.493 181.340 106.041 1.00 81.20  ? 153 PHE A CD2 1 
ATOM   4609 C  CE1 . PHE B 2 162 ? 177.096 182.610 107.879 1.00 83.80  ? 153 PHE A CE1 1 
ATOM   4610 C  CE2 . PHE B 2 162 ? 176.777 180.903 106.254 1.00 84.88  ? 153 PHE A CE2 1 
ATOM   4611 C  CZ  . PHE B 2 162 ? 177.580 181.538 107.174 1.00 87.59  ? 153 PHE A CZ  1 
ATOM   4612 N  N   . LEU B 2 163 ? 170.896 184.617 106.980 1.00 70.65  ? 154 LEU A N   1 
ATOM   4613 C  CA  . LEU B 2 163 ? 169.622 185.006 106.393 1.00 68.72  ? 154 LEU A CA  1 
ATOM   4614 C  C   . LEU B 2 163 ? 169.182 186.413 106.768 1.00 72.09  ? 154 LEU A C   1 
ATOM   4615 O  O   . LEU B 2 163 ? 168.214 186.910 106.188 1.00 74.33  ? 154 LEU A O   1 
ATOM   4616 C  CB  . LEU B 2 163 ? 168.524 184.023 106.812 1.00 66.02  ? 154 LEU A CB  1 
ATOM   4617 C  CG  . LEU B 2 163 ? 168.591 182.626 106.216 1.00 63.26  ? 154 LEU A CG  1 
ATOM   4618 C  CD1 . LEU B 2 163 ? 167.375 181.844 106.631 1.00 59.88  ? 154 LEU A CD1 1 
ATOM   4619 C  CD2 . LEU B 2 163 ? 168.685 182.704 104.717 1.00 65.57  ? 154 LEU A CD2 1 
ATOM   4620 N  N   . SER B 2 164 ? 169.854 187.063 107.719 1.00 73.74  ? 155 SER A N   1 
ATOM   4621 C  CA  . SER B 2 164 ? 169.441 188.406 108.107 1.00 76.51  ? 155 SER A CA  1 
ATOM   4622 C  C   . SER B 2 164 ? 169.491 189.380 106.938 1.00 80.53  ? 155 SER A C   1 
ATOM   4623 O  O   . SER B 2 164 ? 168.744 190.362 106.922 1.00 84.48  ? 155 SER A O   1 
ATOM   4624 C  CB  . SER B 2 164 ? 170.310 188.911 109.254 1.00 76.77  ? 155 SER A CB  1 
ATOM   4625 O  OG  . SER B 2 164 ? 169.886 188.356 110.483 1.00 78.37  ? 155 SER A OG  1 
ATOM   4626 N  N   . LEU B 2 165 ? 170.368 189.141 105.960 1.00 79.35  ? 156 LEU A N   1 
ATOM   4627 C  CA  . LEU B 2 165 ? 170.409 190.015 104.792 1.00 81.53  ? 156 LEU A CA  1 
ATOM   4628 C  C   . LEU B 2 165 ? 169.121 189.919 103.989 1.00 83.64  ? 156 LEU A C   1 
ATOM   4629 O  O   . LEU B 2 165 ? 168.580 190.939 103.548 1.00 89.36  ? 156 LEU A O   1 
ATOM   4630 C  CB  . LEU B 2 165 ? 171.600 189.669 103.904 1.00 79.48  ? 156 LEU A CB  1 
ATOM   4631 C  CG  . LEU B 2 165 ? 172.896 189.214 104.562 1.00 80.87  ? 156 LEU A CG  1 
ATOM   4632 C  CD1 . LEU B 2 165 ? 173.945 188.975 103.495 1.00 82.01  ? 156 LEU A CD1 1 
ATOM   4633 C  CD2 . LEU B 2 165 ? 173.373 190.246 105.561 1.00 83.93  ? 156 LEU A CD2 1 
ATOM   4634 N  N   . PHE B 2 166 ? 168.619 188.704 103.789 1.00 76.38  ? 157 PHE A N   1 
ATOM   4635 C  CA  . PHE B 2 166 ? 167.460 188.471 102.942 1.00 75.45  ? 157 PHE A CA  1 
ATOM   4636 C  C   . PHE B 2 166 ? 166.145 188.506 103.701 1.00 74.41  ? 157 PHE A C   1 
ATOM   4637 O  O   . PHE B 2 166 ? 165.087 188.506 103.065 1.00 76.15  ? 157 PHE A O   1 
ATOM   4638 C  CB  . PHE B 2 166 ? 167.589 187.121 102.234 1.00 72.47  ? 157 PHE A CB  1 
ATOM   4639 C  CG  . PHE B 2 166 ? 168.887 186.939 101.511 1.00 76.61  ? 157 PHE A CG  1 
ATOM   4640 C  CD1 . PHE B 2 166 ? 170.024 186.540 102.184 1.00 78.79  ? 157 PHE A CD1 1 
ATOM   4641 C  CD2 . PHE B 2 166 ? 168.967 187.159 100.153 1.00 80.02  ? 157 PHE A CD2 1 
ATOM   4642 C  CE1 . PHE B 2 166 ? 171.217 186.374 101.515 1.00 81.11  ? 157 PHE A CE1 1 
ATOM   4643 C  CE2 . PHE B 2 166 ? 170.155 186.989 99.483  1.00 83.83  ? 157 PHE A CE2 1 
ATOM   4644 C  CZ  . PHE B 2 166 ? 171.281 186.597 100.165 1.00 83.76  ? 157 PHE A CZ  1 
ATOM   4645 N  N   . LEU B 2 167 ? 166.187 188.540 105.031 1.00 75.82  ? 158 LEU A N   1 
ATOM   4646 C  CA  . LEU B 2 167 ? 164.986 188.490 105.863 1.00 75.66  ? 158 LEU A CA  1 
ATOM   4647 C  C   . LEU B 2 167 ? 164.105 187.301 105.486 1.00 74.68  ? 158 LEU A C   1 
ATOM   4648 O  O   . LEU B 2 167 ? 162.881 187.401 105.417 1.00 77.66  ? 158 LEU A O   1 
ATOM   4649 C  CB  . LEU B 2 167 ? 164.207 189.801 105.785 1.00 76.98  ? 158 LEU A CB  1 
ATOM   4650 C  CG  . LEU B 2 167 ? 164.281 190.671 107.038 1.00 70.45  ? 158 LEU A CG  1 
ATOM   4651 C  CD1 . LEU B 2 167 ? 165.700 191.107 107.298 1.00 73.43  ? 158 LEU A CD1 1 
ATOM   4652 C  CD2 . LEU B 2 167 ? 163.380 191.876 106.908 1.00 84.47  ? 158 LEU A CD2 1 
ATOM   4653 N  N   . LEU B 2 168 ? 164.738 186.171 105.225 1.00 69.48  ? 159 LEU A N   1 
ATOM   4654 C  CA  . LEU B 2 168 ? 164.013 184.932 104.994 1.00 63.08  ? 159 LEU A CA  1 
ATOM   4655 C  C   . LEU B 2 168 ? 163.468 184.433 106.324 1.00 63.29  ? 159 LEU A C   1 
ATOM   4656 O  O   . LEU B 2 168 ? 164.252 184.219 107.255 1.00 63.93  ? 159 LEU A O   1 
ATOM   4657 C  CB  . LEU B 2 168 ? 164.942 183.892 104.379 1.00 65.48  ? 159 LEU A CB  1 
ATOM   4658 C  CG  . LEU B 2 168 ? 164.404 182.856 103.395 1.00 67.71  ? 159 LEU A CG  1 
ATOM   4659 C  CD1 . LEU B 2 168 ? 164.322 183.436 102.007 1.00 68.57  ? 159 LEU A CD1 1 
ATOM   4660 C  CD2 . LEU B 2 168 ? 165.286 181.623 103.395 1.00 62.91  ? 159 LEU A CD2 1 
ATOM   4661 N  N   . PRO B 2 169 ? 162.158 184.249 106.469 1.00 62.22  ? 160 PRO A N   1 
ATOM   4662 C  CA  . PRO B 2 169 ? 161.624 183.770 107.749 1.00 57.31  ? 160 PRO A CA  1 
ATOM   4663 C  C   . PRO B 2 169 ? 162.216 182.423 108.117 1.00 56.86  ? 160 PRO A C   1 
ATOM   4664 O  O   . PRO B 2 169 ? 162.375 181.544 107.271 1.00 64.10  ? 160 PRO A O   1 
ATOM   4665 C  CB  . PRO B 2 169 ? 160.119 183.667 107.490 1.00 58.80  ? 160 PRO A CB  1 
ATOM   4666 C  CG  . PRO B 2 169 ? 159.868 184.569 106.340 1.00 63.69  ? 160 PRO A CG  1 
ATOM   4667 C  CD  . PRO B 2 169 ? 161.095 184.525 105.493 1.00 63.73  ? 160 PRO A CD  1 
ATOM   4668 N  N   . GLN B 2 170 ? 162.535 182.262 109.396 1.00 53.01  ? 161 GLN A N   1 
ATOM   4669 C  CA  . GLN B 2 170 ? 163.164 181.040 109.887 1.00 52.70  ? 161 GLN A CA  1 
ATOM   4670 C  C   . GLN B 2 170 ? 162.584 180.717 111.252 1.00 56.17  ? 161 GLN A C   1 
ATOM   4671 O  O   . GLN B 2 170 ? 162.860 181.424 112.224 1.00 60.27  ? 161 GLN A O   1 
ATOM   4672 C  CB  . GLN B 2 170 ? 164.679 181.190 109.972 1.00 52.32  ? 161 GLN A CB  1 
ATOM   4673 C  CG  . GLN B 2 170 ? 165.365 179.959 110.505 1.00 55.15  ? 161 GLN A CG  1 
ATOM   4674 C  CD  . GLN B 2 170 ? 166.739 180.251 111.038 1.00 64.78  ? 161 GLN A CD  1 
ATOM   4675 O  OE1 . GLN B 2 170 ? 167.337 181.272 110.712 1.00 71.18  ? 161 GLN A OE1 1 
ATOM   4676 N  NE2 . GLN B 2 170 ? 167.256 179.353 111.862 1.00 66.22  ? 161 GLN A NE2 1 
ATOM   4677 N  N   . ILE B 2 171 ? 161.796 179.654 111.331 1.00 51.66  ? 162 ILE A N   1 
ATOM   4678 C  CA  . ILE B 2 171 ? 161.178 179.227 112.578 1.00 52.46  ? 162 ILE A CA  1 
ATOM   4679 C  C   . ILE B 2 171 ? 161.932 178.012 113.084 1.00 54.58  ? 162 ILE A C   1 
ATOM   4680 O  O   . ILE B 2 171 ? 161.827 176.921 112.517 1.00 59.81  ? 162 ILE A O   1 
ATOM   4681 C  CB  . ILE B 2 171 ? 159.690 178.919 112.395 1.00 52.20  ? 162 ILE A CB  1 
ATOM   4682 C  CG1 . ILE B 2 171 ? 158.958 180.180 111.970 1.00 56.50  ? 162 ILE A CG1 1 
ATOM   4683 C  CG2 . ILE B 2 171 ? 159.109 178.390 113.677 1.00 57.14  ? 162 ILE A CG2 1 
ATOM   4684 C  CD1 . ILE B 2 171 ? 158.621 180.211 110.535 1.00 59.04  ? 162 ILE A CD1 1 
ATOM   4685 N  N   . THR B 2 172 ? 162.685 178.190 114.157 1.00 56.28  ? 163 THR A N   1 
ATOM   4686 C  CA  . THR B 2 172 ? 163.420 177.089 114.747 1.00 59.10  ? 163 THR A CA  1 
ATOM   4687 C  C   . THR B 2 172 ? 162.545 176.361 115.753 1.00 63.00  ? 163 THR A C   1 
ATOM   4688 O  O   . THR B 2 172 ? 161.613 176.927 116.325 1.00 68.06  ? 163 THR A O   1 
ATOM   4689 C  CB  . THR B 2 172 ? 164.693 177.582 115.431 1.00 63.60  ? 163 THR A CB  1 
ATOM   4690 O  OG1 . THR B 2 172 ? 165.331 176.489 116.097 1.00 66.99  ? 163 THR A OG1 1 
ATOM   4691 C  CG2 . THR B 2 172 ? 164.362 178.645 116.450 1.00 61.85  ? 163 THR A CG2 1 
ATOM   4692 N  N   . TYR B 2 173 ? 162.844 175.087 115.944 1.00 65.35  ? 164 TYR A N   1 
ATOM   4693 C  CA  . TYR B 2 173 ? 162.239 174.265 116.974 1.00 69.92  ? 164 TYR A CA  1 
ATOM   4694 C  C   . TYR B 2 173 ? 163.328 173.809 117.933 1.00 75.61  ? 164 TYR A C   1 
ATOM   4695 O  O   . TYR B 2 173 ? 164.481 173.626 117.537 1.00 78.89  ? 164 TYR A O   1 
ATOM   4696 C  CB  . TYR B 2 173 ? 161.535 173.057 116.357 1.00 68.74  ? 164 TYR A CB  1 
ATOM   4697 C  CG  . TYR B 2 173 ? 162.417 172.311 115.389 1.00 70.24  ? 164 TYR A CG  1 
ATOM   4698 C  CD1 . TYR B 2 173 ? 163.328 171.369 115.833 1.00 72.34  ? 164 TYR A CD1 1 
ATOM   4699 C  CD2 . TYR B 2 173 ? 162.353 172.563 114.030 1.00 64.97  ? 164 TYR A CD2 1 
ATOM   4700 C  CE1 . TYR B 2 173 ? 164.143 170.700 114.956 1.00 71.36  ? 164 TYR A CE1 1 
ATOM   4701 C  CE2 . TYR B 2 173 ? 163.163 171.895 113.145 1.00 63.13  ? 164 TYR A CE2 1 
ATOM   4702 C  CZ  . TYR B 2 173 ? 164.056 170.965 113.615 1.00 68.77  ? 164 TYR A CZ  1 
ATOM   4703 O  OH  . TYR B 2 173 ? 164.869 170.290 112.742 1.00 69.96  ? 164 TYR A OH  1 
ATOM   4704 N  N   . SER B 2 174 ? 162.965 173.656 119.203 1.00 73.73  ? 165 SER A N   1 
ATOM   4705 C  CA  . SER B 2 174 ? 163.859 173.101 120.217 1.00 80.06  ? 165 SER A CA  1 
ATOM   4706 C  C   . SER B 2 174 ? 165.172 173.873 120.329 1.00 77.24  ? 165 SER A C   1 
ATOM   4707 O  O   . SER B 2 174 ? 166.190 173.323 120.750 1.00 81.47  ? 165 SER A O   1 
ATOM   4708 C  CB  . SER B 2 174 ? 164.140 171.621 119.955 1.00 85.14  ? 165 SER A CB  1 
ATOM   4709 O  OG  . SER B 2 174 ? 165.148 171.455 118.976 1.00 89.10  ? 165 SER A OG  1 
ATOM   4710 N  N   . ALA B 2 175 ? 165.173 175.145 119.954 1.00 73.45  ? 166 ALA A N   1 
ATOM   4711 C  CA  . ALA B 2 175 ? 166.298 176.030 120.219 1.00 74.71  ? 166 ALA A CA  1 
ATOM   4712 C  C   . ALA B 2 175 ? 165.950 176.855 121.449 1.00 81.45  ? 166 ALA A C   1 
ATOM   4713 O  O   . ALA B 2 175 ? 164.909 177.514 121.480 1.00 83.84  ? 166 ALA A O   1 
ATOM   4714 C  CB  . ALA B 2 175 ? 166.592 176.931 119.023 1.00 75.46  ? 166 ALA A CB  1 
ATOM   4715 N  N   . ILE B 2 176 ? 166.805 176.806 122.467 1.00 82.19  ? 167 ILE A N   1 
ATOM   4716 C  CA  . ILE B 2 176 ? 166.467 177.366 123.766 1.00 79.78  ? 167 ILE A CA  1 
ATOM   4717 C  C   . ILE B 2 176 ? 167.360 178.525 124.166 1.00 81.78  ? 167 ILE A C   1 
ATOM   4718 O  O   . ILE B 2 176 ? 167.132 179.122 125.218 1.00 86.93  ? 167 ILE A O   1 
ATOM   4719 C  CB  . ILE B 2 176 ? 166.486 176.285 124.863 1.00 74.35  ? 167 ILE A CB  1 
ATOM   4720 C  CG1 . ILE B 2 176 ? 167.923 175.861 125.153 1.00 74.67  ? 167 ILE A CG1 1 
ATOM   4721 C  CG2 . ILE B 2 176 ? 165.648 175.098 124.443 1.00 75.85  ? 167 ILE A CG2 1 
ATOM   4722 C  CD1 . ILE B 2 176 ? 168.203 175.645 126.614 1.00 77.41  ? 167 ILE A CD1 1 
ATOM   4723 N  N   . SER B 2 177 ? 168.366 178.866 123.370 1.00 78.68  ? 168 SER A N   1 
ATOM   4724 C  CA  . SER B 2 177 ? 169.268 179.936 123.766 1.00 77.21  ? 168 SER A CA  1 
ATOM   4725 C  C   . SER B 2 177 ? 168.509 181.245 123.917 1.00 80.47  ? 168 SER A C   1 
ATOM   4726 O  O   . SER B 2 177 ? 167.678 181.601 123.080 1.00 80.87  ? 168 SER A O   1 
ATOM   4727 C  CB  . SER B 2 177 ? 170.389 180.099 122.745 1.00 79.26  ? 168 SER A CB  1 
ATOM   4728 O  OG  . SER B 2 177 ? 171.078 181.319 122.953 1.00 80.77  ? 168 SER A OG  1 
ATOM   4729 N  N   . ASP B 2 178 ? 168.786 181.956 125.008 1.00 81.89  ? 169 ASP A N   1 
ATOM   4730 C  CA  . ASP B 2 178 ? 168.187 183.266 125.217 1.00 82.68  ? 169 ASP A CA  1 
ATOM   4731 C  C   . ASP B 2 178 ? 168.795 184.330 124.319 1.00 82.56  ? 169 ASP A C   1 
ATOM   4732 O  O   . ASP B 2 178 ? 168.237 185.426 124.219 1.00 80.71  ? 169 ASP A O   1 
ATOM   4733 C  CB  . ASP B 2 178 ? 168.334 183.679 126.680 1.00 81.03  ? 169 ASP A CB  1 
ATOM   4734 C  CG  . ASP B 2 178 ? 167.025 183.621 127.434 1.00 80.60  ? 169 ASP A CG  1 
ATOM   4735 O  OD1 . ASP B 2 178 ? 166.007 183.234 126.827 1.00 81.19  ? 169 ASP A OD1 1 
ATOM   4736 O  OD2 . ASP B 2 178 ? 167.015 183.958 128.635 1.00 81.14  ? 169 ASP A OD2 1 
ATOM   4737 N  N   . GLU B 2 179 ? 169.921 184.033 123.671 1.00 82.92  ? 170 GLU A N   1 
ATOM   4738 C  CA  . GLU B 2 179 ? 170.559 184.995 122.784 1.00 80.47  ? 170 GLU A CA  1 
ATOM   4739 C  C   . GLU B 2 179 ? 169.742 185.250 121.525 1.00 77.73  ? 170 GLU A C   1 
ATOM   4740 O  O   . GLU B 2 179 ? 169.927 186.288 120.884 1.00 82.33  ? 170 GLU A O   1 
ATOM   4741 C  CB  . GLU B 2 179 ? 171.959 184.504 122.415 1.00 86.70  ? 170 GLU A CB  1 
ATOM   4742 C  CG  . GLU B 2 179 ? 172.906 185.591 121.940 1.00 94.27  ? 170 GLU A CG  1 
ATOM   4743 C  CD  . GLU B 2 179 ? 174.361 185.221 122.151 1.00 106.35 ? 170 GLU A CD  1 
ATOM   4744 O  OE1 . GLU B 2 179 ? 174.622 184.215 122.841 1.00 113.66 ? 170 GLU A OE1 1 
ATOM   4745 O  OE2 . GLU B 2 179 ? 175.243 185.933 121.627 1.00 103.93 ? 170 GLU A OE2 1 
ATOM   4746 N  N   . LEU B 2 180 ? 168.846 184.337 121.159 1.00 74.10  ? 171 LEU A N   1 
ATOM   4747 C  CA  . LEU B 2 180 ? 167.979 184.517 120.004 1.00 73.54  ? 171 LEU A CA  1 
ATOM   4748 C  C   . LEU B 2 180 ? 166.711 185.295 120.326 1.00 77.29  ? 171 LEU A C   1 
ATOM   4749 O  O   . LEU B 2 180 ? 165.897 185.519 119.427 1.00 78.51  ? 171 LEU A O   1 
ATOM   4750 C  CB  . LEU B 2 180 ? 167.595 183.163 119.404 1.00 69.34  ? 171 LEU A CB  1 
ATOM   4751 C  CG  . LEU B 2 180 ? 168.652 182.065 119.371 1.00 68.30  ? 171 LEU A CG  1 
ATOM   4752 C  CD1 . LEU B 2 180 ? 168.018 180.758 118.956 1.00 62.51  ? 171 LEU A CD1 1 
ATOM   4753 C  CD2 . LEU B 2 180 ? 169.772 182.431 118.430 1.00 73.12  ? 171 LEU A CD2 1 
ATOM   4754 N  N   . ARG B 2 181 ? 166.512 185.692 121.582 1.00 79.62  ? 172 ARG A N   1 
ATOM   4755 C  CA  . ARG B 2 181 ? 165.296 186.414 121.936 1.00 80.95  ? 172 ARG A CA  1 
ATOM   4756 C  C   . ARG B 2 181 ? 165.248 187.784 121.274 1.00 83.83  ? 172 ARG A C   1 
ATOM   4757 O  O   . ARG B 2 181 ? 164.196 188.201 120.777 1.00 83.94  ? 172 ARG A O   1 
ATOM   4758 C  CB  . ARG B 2 181 ? 165.187 186.551 123.452 1.00 81.46  ? 172 ARG A CB  1 
ATOM   4759 C  CG  . ARG B 2 181 ? 164.201 185.589 124.092 1.00 84.55  ? 172 ARG A CG  1 
ATOM   4760 C  CD  . ARG B 2 181 ? 163.683 186.131 125.411 1.00 86.34  ? 172 ARG A CD  1 
ATOM   4761 N  NE  . ARG B 2 181 ? 162.435 186.863 125.241 1.00 92.14  ? 172 ARG A NE  1 
ATOM   4762 C  CZ  . ARG B 2 181 ? 161.231 186.332 125.405 1.00 92.62  ? 172 ARG A CZ  1 
ATOM   4763 N  NH1 . ARG B 2 181 ? 161.078 185.066 125.758 1.00 86.41  ? 172 ARG A NH1 1 
ATOM   4764 N  NH2 . ARG B 2 181 ? 160.155 187.089 125.213 1.00 94.11  ? 172 ARG A NH2 1 
ATOM   4765 N  N   . ASP B 2 182 ? 166.368 188.500 121.257 1.00 84.81  ? 173 ASP A N   1 
ATOM   4766 C  CA  . ASP B 2 182 ? 166.370 189.863 120.745 1.00 82.61  ? 173 ASP A CA  1 
ATOM   4767 C  C   . ASP B 2 182 ? 166.276 189.881 119.224 1.00 80.57  ? 173 ASP A C   1 
ATOM   4768 O  O   . ASP B 2 182 ? 166.830 189.026 118.531 1.00 78.90  ? 173 ASP A O   1 
ATOM   4769 C  CB  . ASP B 2 182 ? 167.621 190.610 121.202 1.00 83.39  ? 173 ASP A CB  1 
ATOM   4770 C  CG  . ASP B 2 182 ? 168.864 190.172 120.467 1.00 82.48  ? 173 ASP A CG  1 
ATOM   4771 O  OD1 . ASP B 2 182 ? 169.002 188.965 120.192 1.00 80.31  ? 173 ASP A OD1 1 
ATOM   4772 O  OD2 . ASP B 2 182 ? 169.707 191.040 120.166 1.00 82.44  ? 173 ASP A OD2 1 
ATOM   4773 N  N   . LYS B 2 183 ? 165.559 190.876 118.707 1.00 79.24  ? 174 LYS A N   1 
ATOM   4774 C  CA  . LYS B 2 183 ? 165.338 191.023 117.276 1.00 74.34  ? 174 LYS A CA  1 
ATOM   4775 C  C   . LYS B 2 183 ? 166.191 192.122 116.660 1.00 72.97  ? 174 LYS A C   1 
ATOM   4776 O  O   . LYS B 2 183 ? 165.954 192.506 115.511 1.00 71.45  ? 174 LYS A O   1 
ATOM   4777 C  CB  . LYS B 2 183 ? 163.857 191.283 117.001 1.00 74.98  ? 174 LYS A CB  1 
ATOM   4778 C  CG  . LYS B 2 183 ? 162.976 190.084 117.291 1.00 77.61  ? 174 LYS A CG  1 
ATOM   4779 C  CD  . LYS B 2 183 ? 163.659 188.804 116.856 1.00 76.61  ? 174 LYS A CD  1 
ATOM   4780 C  CE  . LYS B 2 183 ? 162.911 187.581 117.327 1.00 77.53  ? 174 LYS A CE  1 
ATOM   4781 N  NZ  . LYS B 2 183 ? 163.832 186.440 117.557 1.00 71.30  ? 174 LYS A NZ  1 
ATOM   4782 N  N   . VAL B 2 184 ? 167.160 192.656 117.401 1.00 76.55  ? 175 VAL A N   1 
ATOM   4783 C  CA  . VAL B 2 184 ? 168.080 193.623 116.816 1.00 74.05  ? 175 VAL A CA  1 
ATOM   4784 C  C   . VAL B 2 184 ? 169.024 192.936 115.839 1.00 74.10  ? 175 VAL A C   1 
ATOM   4785 O  O   . VAL B 2 184 ? 169.258 193.430 114.730 1.00 75.38  ? 175 VAL A O   1 
ATOM   4786 C  CB  . VAL B 2 184 ? 168.849 194.365 117.923 1.00 74.44  ? 175 VAL A CB  1 
ATOM   4787 C  CG1 . VAL B 2 184 ? 170.059 195.074 117.347 1.00 74.41  ? 175 VAL A CG1 1 
ATOM   4788 C  CG2 . VAL B 2 184 ? 167.936 195.354 118.624 1.00 73.76  ? 175 VAL A CG2 1 
ATOM   4789 N  N   . ARG B 2 185 ? 169.571 191.784 116.224 1.00 75.67  ? 176 ARG A N   1 
ATOM   4790 C  CA  . ARG B 2 185 ? 170.536 191.069 115.402 1.00 73.06  ? 176 ARG A CA  1 
ATOM   4791 C  C   . ARG B 2 185 ? 169.969 189.816 114.750 1.00 77.32  ? 176 ARG A C   1 
ATOM   4792 O  O   . ARG B 2 185 ? 170.662 189.200 113.935 1.00 82.61  ? 176 ARG A O   1 
ATOM   4793 C  CB  . ARG B 2 185 ? 171.763 190.686 116.235 1.00 71.36  ? 176 ARG A CB  1 
ATOM   4794 C  CG  . ARG B 2 185 ? 171.428 190.189 117.624 1.00 76.38  ? 176 ARG A CG  1 
ATOM   4795 C  CD  . ARG B 2 185 ? 172.680 189.964 118.441 1.00 76.40  ? 176 ARG A CD  1 
ATOM   4796 N  NE  . ARG B 2 185 ? 173.536 188.947 117.846 1.00 82.94  ? 176 ARG A NE  1 
ATOM   4797 C  CZ  . ARG B 2 185 ? 174.188 188.021 118.536 1.00 85.76  ? 176 ARG A CZ  1 
ATOM   4798 N  NH1 . ARG B 2 185 ? 174.093 187.947 119.852 1.00 85.53  ? 176 ARG A NH1 1 
ATOM   4799 N  NH2 . ARG B 2 185 ? 174.954 187.149 117.888 1.00 85.35  ? 176 ARG A NH2 1 
ATOM   4800 N  N   . PHE B 2 186 ? 168.745 189.419 115.089 1.00 78.12  ? 177 PHE A N   1 
ATOM   4801 C  CA  . PHE B 2 186 ? 168.074 188.280 114.462 1.00 72.78  ? 177 PHE A CA  1 
ATOM   4802 C  C   . PHE B 2 186 ? 166.683 188.704 114.018 1.00 69.87  ? 177 PHE A C   1 
ATOM   4803 O  O   . PHE B 2 186 ? 165.675 188.220 114.542 1.00 71.95  ? 177 PHE A O   1 
ATOM   4804 C  CB  . PHE B 2 186 ? 167.990 187.088 115.415 1.00 67.97  ? 177 PHE A CB  1 
ATOM   4805 C  CG  . PHE B 2 186 ? 169.319 186.575 115.863 1.00 68.56  ? 177 PHE A CG  1 
ATOM   4806 C  CD1 . PHE B 2 186 ? 170.246 186.135 114.944 1.00 70.61  ? 177 PHE A CD1 1 
ATOM   4807 C  CD2 . PHE B 2 186 ? 169.633 186.510 117.201 1.00 72.87  ? 177 PHE A CD2 1 
ATOM   4808 C  CE1 . PHE B 2 186 ? 171.464 185.653 115.350 1.00 71.96  ? 177 PHE A CE1 1 
ATOM   4809 C  CE2 . PHE B 2 186 ? 170.853 186.028 117.612 1.00 78.53  ? 177 PHE A CE2 1 
ATOM   4810 C  CZ  . PHE B 2 186 ? 171.769 185.601 116.684 1.00 76.70  ? 177 PHE A CZ  1 
ATOM   4811 N  N   . PRO B 2 187 ? 166.592 189.606 113.042 1.00 65.55  ? 178 PRO A N   1 
ATOM   4812 C  CA  . PRO B 2 187 ? 165.271 190.114 112.649 1.00 66.30  ? 178 PRO A CA  1 
ATOM   4813 C  C   . PRO B 2 187 ? 164.354 189.049 112.087 1.00 66.18  ? 178 PRO A C   1 
ATOM   4814 O  O   . PRO B 2 187 ? 163.130 189.172 112.213 1.00 66.07  ? 178 PRO A O   1 
ATOM   4815 C  CB  . PRO B 2 187 ? 165.605 191.181 111.597 1.00 68.82  ? 178 PRO A CB  1 
ATOM   4816 C  CG  . PRO B 2 187 ? 167.074 191.434 111.733 1.00 70.63  ? 178 PRO A CG  1 
ATOM   4817 C  CD  . PRO B 2 187 ? 167.661 190.153 112.198 1.00 67.48  ? 178 PRO A CD  1 
ATOM   4818 N  N   . ALA B 2 188 ? 164.902 188.008 111.467 1.00 63.62  ? 179 ALA A N   1 
ATOM   4819 C  CA  . ALA B 2 188 ? 164.110 187.022 110.749 1.00 63.14  ? 179 ALA A CA  1 
ATOM   4820 C  C   . ALA B 2 188 ? 164.004 185.691 111.475 1.00 62.31  ? 179 ALA A C   1 
ATOM   4821 O  O   . ALA B 2 188 ? 163.607 184.698 110.862 1.00 65.83  ? 179 ALA A O   1 
ATOM   4822 C  CB  . ALA B 2 188 ? 164.691 186.800 109.354 1.00 65.39  ? 179 ALA A CB  1 
ATOM   4823 N  N   . LEU B 2 189 ? 164.347 185.640 112.756 1.00 63.88  ? 180 LEU A N   1 
ATOM   4824 C  CA  . LEU B 2 189 ? 164.301 184.403 113.523 1.00 61.15  ? 180 LEU A CA  1 
ATOM   4825 C  C   . LEU B 2 189 ? 163.049 184.375 114.387 1.00 61.16  ? 180 LEU A C   1 
ATOM   4826 O  O   . LEU B 2 189 ? 162.740 185.355 115.071 1.00 65.77  ? 180 LEU A O   1 
ATOM   4827 C  CB  . LEU B 2 189 ? 165.543 184.257 114.401 1.00 57.67  ? 180 LEU A CB  1 
ATOM   4828 C  CG  . LEU B 2 189 ? 165.695 182.921 115.124 1.00 53.84  ? 180 LEU A CG  1 
ATOM   4829 C  CD1 . LEU B 2 189 ? 165.462 181.782 114.171 1.00 56.58  ? 180 LEU A CD1 1 
ATOM   4830 C  CD2 . LEU B 2 189 ? 167.065 182.812 115.742 1.00 61.16  ? 180 LEU A CD2 1 
ATOM   4831 N  N   . LEU B 2 190 ? 162.338 183.259 114.352 1.00 55.46  ? 181 LEU A N   1 
ATOM   4832 C  CA  . LEU B 2 190 ? 161.191 183.015 115.210 1.00 56.99  ? 181 LEU A CA  1 
ATOM   4833 C  C   . LEU B 2 190 ? 161.427 181.711 115.965 1.00 62.94  ? 181 LEU A C   1 
ATOM   4834 O  O   . LEU B 2 190 ? 162.518 181.143 115.926 1.00 65.63  ? 181 LEU A O   1 
ATOM   4835 C  CB  . LEU B 2 190 ? 159.904 182.980 114.390 1.00 53.88  ? 181 LEU A CB  1 
ATOM   4836 C  CG  . LEU B 2 190 ? 159.721 184.147 113.427 1.00 56.33  ? 181 LEU A CG  1 
ATOM   4837 C  CD1 . LEU B 2 190 ? 158.720 183.777 112.366 1.00 58.70  ? 181 LEU A CD1 1 
ATOM   4838 C  CD2 . LEU B 2 190 ? 159.279 185.382 114.172 1.00 60.53  ? 181 LEU A CD2 1 
ATOM   4839 N  N   . ARG B 2 191 ? 160.399 181.236 116.660 1.00 63.74  ? 182 ARG A N   1 
ATOM   4840 C  CA  . ARG B 2 191 ? 160.560 180.037 117.470 1.00 63.05  ? 182 ARG A CA  1 
ATOM   4841 C  C   . ARG B 2 191 ? 159.196 179.422 117.731 1.00 64.48  ? 182 ARG A C   1 
ATOM   4842 O  O   . ARG B 2 191 ? 158.161 180.050 117.506 1.00 66.23  ? 182 ARG A O   1 
ATOM   4843 C  CB  . ARG B 2 191 ? 161.269 180.350 118.787 1.00 65.77  ? 182 ARG A CB  1 
ATOM   4844 C  CG  . ARG B 2 191 ? 161.954 179.164 119.401 1.00 63.20  ? 182 ARG A CG  1 
ATOM   4845 C  CD  . ARG B 2 191 ? 163.301 179.538 119.948 1.00 67.14  ? 182 ARG A CD  1 
ATOM   4846 N  NE  . ARG B 2 191 ? 163.230 180.643 120.892 1.00 77.24  ? 182 ARG A NE  1 
ATOM   4847 C  CZ  . ARG B 2 191 ? 164.268 181.103 121.574 1.00 83.24  ? 182 ARG A CZ  1 
ATOM   4848 N  NH1 . ARG B 2 191 ? 165.469 180.568 121.444 1.00 82.05  ? 182 ARG A NH1 1 
ATOM   4849 N  NH2 . ARG B 2 191 ? 164.095 182.120 122.412 1.00 87.17  ? 182 ARG A NH2 1 
ATOM   4850 N  N   . THR B 2 192 ? 159.209 178.174 118.202 1.00 64.34  ? 183 THR A N   1 
ATOM   4851 C  CA  . THR B 2 192 ? 157.992 177.493 118.625 1.00 63.73  ? 183 THR A CA  1 
ATOM   4852 C  C   . THR B 2 192 ? 158.187 176.742 119.935 1.00 68.88  ? 183 THR A C   1 
ATOM   4853 O  O   . THR B 2 192 ? 157.396 175.852 120.255 1.00 72.84  ? 183 THR A O   1 
ATOM   4854 C  CB  . THR B 2 192 ? 157.498 176.533 117.546 1.00 62.59  ? 183 THR A CB  1 
ATOM   4855 O  OG1 . THR B 2 192 ? 158.621 175.966 116.865 1.00 67.63  ? 183 THR A OG1 1 
ATOM   4856 C  CG2 . THR B 2 192 ? 156.625 177.264 116.555 1.00 60.19  ? 183 THR A CG2 1 
ATOM   4857 N  N   . THR B 2 193 ? 159.224 177.072 120.694 1.00 69.68  ? 184 THR A N   1 
ATOM   4858 C  CA  . THR B 2 193 ? 159.476 176.464 121.987 1.00 71.94  ? 184 THR A CA  1 
ATOM   4859 C  C   . THR B 2 193 ? 159.848 177.555 122.977 1.00 78.21  ? 184 THR A C   1 
ATOM   4860 O  O   . THR B 2 193 ? 160.452 178.563 122.593 1.00 80.95  ? 184 THR A O   1 
ATOM   4861 C  CB  . THR B 2 193 ? 160.608 175.429 121.912 1.00 73.42  ? 184 THR A CB  1 
ATOM   4862 O  OG1 . THR B 2 193 ? 161.023 175.072 123.234 1.00 80.57  ? 184 THR A OG1 1 
ATOM   4863 C  CG2 . THR B 2 193 ? 161.789 176.002 121.167 1.00 74.00  ? 184 THR A CG2 1 
ATOM   4864 N  N   . PRO B 2 194 ? 159.493 177.391 124.249 1.00 77.04  ? 185 PRO A N   1 
ATOM   4865 C  CA  . PRO B 2 194 ? 159.910 178.372 125.255 1.00 73.38  ? 185 PRO A CA  1 
ATOM   4866 C  C   . PRO B 2 194 ? 161.423 178.412 125.389 1.00 73.20  ? 185 PRO A C   1 
ATOM   4867 O  O   . PRO B 2 194 ? 162.114 177.410 125.204 1.00 79.83  ? 185 PRO A O   1 
ATOM   4868 C  CB  . PRO B 2 194 ? 159.248 177.866 126.540 1.00 69.46  ? 185 PRO A CB  1 
ATOM   4869 C  CG  . PRO B 2 194 ? 158.125 177.030 126.080 1.00 71.84  ? 185 PRO A CG  1 
ATOM   4870 C  CD  . PRO B 2 194 ? 158.569 176.393 124.806 1.00 73.32  ? 185 PRO A CD  1 
ATOM   4871 N  N   . SER B 2 195 ? 161.936 179.593 125.716 1.00 68.58  ? 186 SER A N   1 
ATOM   4872 C  CA  . SER B 2 195 ? 163.372 179.786 125.802 1.00 73.42  ? 186 SER A CA  1 
ATOM   4873 C  C   . SER B 2 195 ? 163.924 179.105 127.051 1.00 78.29  ? 186 SER A C   1 
ATOM   4874 O  O   . SER B 2 195 ? 163.204 178.461 127.816 1.00 78.89  ? 186 SER A O   1 
ATOM   4875 C  CB  . SER B 2 195 ? 163.703 181.274 125.792 1.00 78.44  ? 186 SER A CB  1 
ATOM   4876 O  OG  . SER B 2 195 ? 162.683 182.022 126.427 1.00 83.16  ? 186 SER A OG  1 
ATOM   4877 N  N   . ALA B 2 196 ? 165.235 179.248 127.257 1.00 80.13  ? 187 ALA A N   1 
ATOM   4878 C  CA  . ALA B 2 196 ? 165.875 178.659 128.425 1.00 74.53  ? 187 ALA A CA  1 
ATOM   4879 C  C   . ALA B 2 196 ? 165.417 179.308 129.719 1.00 75.06  ? 187 ALA A C   1 
ATOM   4880 O  O   . ALA B 2 196 ? 165.534 178.689 130.781 1.00 78.85  ? 187 ALA A O   1 
ATOM   4881 C  CB  . ALA B 2 196 ? 167.394 178.765 128.316 1.00 73.24  ? 187 ALA A CB  1 
ATOM   4882 N  N   . ASP B 2 197 ? 164.905 180.536 129.655 1.00 70.35  ? 188 ASP A N   1 
ATOM   4883 C  CA  . ASP B 2 197 ? 164.389 181.182 130.855 1.00 70.98  ? 188 ASP A CA  1 
ATOM   4884 C  C   . ASP B 2 197 ? 163.265 180.361 131.468 1.00 70.39  ? 188 ASP A C   1 
ATOM   4885 O  O   . ASP B 2 197 ? 163.247 180.115 132.679 1.00 74.68  ? 188 ASP A O   1 
ATOM   4886 C  CB  . ASP B 2 197 ? 163.912 182.592 130.515 1.00 75.94  ? 188 ASP A CB  1 
ATOM   4887 C  CG  . ASP B 2 197 ? 163.626 183.419 131.743 1.00 86.61  ? 188 ASP A CG  1 
ATOM   4888 O  OD1 . ASP B 2 197 ? 163.977 182.975 132.853 1.00 91.07  ? 188 ASP A OD1 1 
ATOM   4889 O  OD2 . ASP B 2 197 ? 163.055 184.520 131.597 1.00 88.56  ? 188 ASP A OD2 1 
ATOM   4890 N  N   . HIS B 2 198 ? 162.333 179.896 130.638 1.00 66.84  ? 189 HIS A N   1 
ATOM   4891 C  CA  . HIS B 2 198 ? 161.234 179.089 131.152 1.00 63.08  ? 189 HIS A CA  1 
ATOM   4892 C  C   . HIS B 2 198 ? 161.703 177.713 131.601 1.00 66.14  ? 189 HIS A C   1 
ATOM   4893 O  O   . HIS B 2 198 ? 161.166 177.172 132.570 1.00 74.81  ? 189 HIS A O   1 
ATOM   4894 C  CB  . HIS B 2 198 ? 160.137 178.973 130.102 1.00 62.38  ? 189 HIS A CB  1 
ATOM   4895 C  CG  . HIS B 2 198 ? 159.506 180.282 129.755 1.00 66.56  ? 189 HIS A CG  1 
ATOM   4896 N  ND1 . HIS B 2 198 ? 158.723 180.987 130.641 1.00 70.25  ? 189 HIS A ND1 1 
ATOM   4897 C  CD2 . HIS B 2 198 ? 159.556 181.025 128.625 1.00 70.69  ? 189 HIS A CD2 1 
ATOM   4898 C  CE1 . HIS B 2 198 ? 158.310 182.104 130.069 1.00 73.83  ? 189 HIS A CE1 1 
ATOM   4899 N  NE2 . HIS B 2 198 ? 158.802 182.151 128.845 1.00 73.48  ? 189 HIS A NE2 1 
ATOM   4900 N  N   . HIS B 2 199 ? 162.697 177.130 130.928 1.00 62.29  ? 190 HIS A N   1 
ATOM   4901 C  CA  . HIS B 2 199 ? 163.240 175.852 131.382 1.00 65.43  ? 190 HIS A CA  1 
ATOM   4902 C  C   . HIS B 2 199 ? 163.836 175.977 132.780 1.00 65.24  ? 190 HIS A C   1 
ATOM   4903 O  O   . HIS B 2 199 ? 163.555 175.162 133.670 1.00 65.60  ? 190 HIS A O   1 
ATOM   4904 C  CB  . HIS B 2 199 ? 164.298 175.352 130.401 1.00 67.71  ? 190 HIS A CB  1 
ATOM   4905 C  CG  . HIS B 2 199 ? 163.736 174.726 129.164 1.00 71.25  ? 190 HIS A CG  1 
ATOM   4906 N  ND1 . HIS B 2 199 ? 162.690 175.275 128.460 1.00 71.55  ? 190 HIS A ND1 1 
ATOM   4907 C  CD2 . HIS B 2 199 ? 164.088 173.601 128.500 1.00 70.04  ? 190 HIS A CD2 1 
ATOM   4908 C  CE1 . HIS B 2 199 ? 162.415 174.511 127.418 1.00 68.33  ? 190 HIS A CE1 1 
ATOM   4909 N  NE2 . HIS B 2 199 ? 163.251 173.490 127.418 1.00 68.00  ? 190 HIS A NE2 1 
ATOM   4910 N  N   . ILE B 2 200 ? 164.664 177.000 132.989 1.00 65.24  ? 191 ILE A N   1 
ATOM   4911 C  CA  . ILE B 2 200 ? 165.281 177.202 134.293 1.00 63.43  ? 191 ILE A CA  1 
ATOM   4912 C  C   . ILE B 2 200 ? 164.223 177.521 135.338 1.00 66.99  ? 191 ILE A C   1 
ATOM   4913 O  O   . ILE B 2 200 ? 164.315 177.080 136.489 1.00 69.11  ? 191 ILE A O   1 
ATOM   4914 C  CB  . ILE B 2 200 ? 166.346 178.308 134.212 1.00 67.90  ? 191 ILE A CB  1 
ATOM   4915 C  CG1 . ILE B 2 200 ? 167.436 177.925 133.213 1.00 69.37  ? 191 ILE A CG1 1 
ATOM   4916 C  CG2 . ILE B 2 200 ? 166.949 178.558 135.571 1.00 70.32  ? 191 ILE A CG2 1 
ATOM   4917 C  CD1 . ILE B 2 200 ? 167.876 176.492 133.308 1.00 67.21  ? 191 ILE A CD1 1 
ATOM   4918 N  N   . GLU B 2 201 ? 163.202 178.290 134.958 1.00 67.54  ? 192 GLU A N   1 
ATOM   4919 C  CA  . GLU B 2 201 ? 162.125 178.585 135.892 1.00 65.73  ? 192 GLU A CA  1 
ATOM   4920 C  C   . GLU B 2 201 ? 161.388 177.319 136.299 1.00 65.89  ? 192 GLU A C   1 
ATOM   4921 O  O   . GLU B 2 201 ? 161.045 177.147 137.470 1.00 73.50  ? 192 GLU A O   1 
ATOM   4922 C  CB  . GLU B 2 201 ? 161.159 179.593 135.279 1.00 66.21  ? 192 GLU A CB  1 
ATOM   4923 C  CG  . GLU B 2 201 ? 160.000 179.952 136.179 1.00 73.65  ? 192 GLU A CG  1 
ATOM   4924 C  CD  . GLU B 2 201 ? 160.446 180.658 137.437 1.00 85.53  ? 192 GLU A CD  1 
ATOM   4925 O  OE1 . GLU B 2 201 ? 161.416 181.439 137.364 1.00 91.80  ? 192 GLU A OE1 1 
ATOM   4926 O  OE2 . GLU B 2 201 ? 159.825 180.439 138.498 1.00 87.23  ? 192 GLU A OE2 1 
ATOM   4927 N  N   . ALA B 2 202 ? 161.133 176.421 135.348 1.00 60.89  ? 193 ALA A N   1 
ATOM   4928 C  CA  . ALA B 2 202 ? 160.467 175.168 135.685 1.00 58.71  ? 193 ALA A CA  1 
ATOM   4929 C  C   . ALA B 2 202 ? 161.326 174.330 136.618 1.00 60.41  ? 193 ALA A C   1 
ATOM   4930 O  O   . ALA B 2 202 ? 160.819 173.740 137.580 1.00 61.91  ? 193 ALA A O   1 
ATOM   4931 C  CB  . ALA B 2 202 ? 160.134 174.388 134.416 1.00 58.91  ? 193 ALA A CB  1 
ATOM   4932 N  N   . MET B 2 203 ? 162.634 174.272 136.354 1.00 63.26  ? 194 MET A N   1 
ATOM   4933 C  CA  . MET B 2 203 ? 163.526 173.544 137.252 1.00 61.47  ? 194 MET A CA  1 
ATOM   4934 C  C   . MET B 2 203 ? 163.475 174.117 138.661 1.00 66.15  ? 194 MET A C   1 
ATOM   4935 O  O   . MET B 2 203 ? 163.367 173.369 139.639 1.00 70.29  ? 194 MET A O   1 
ATOM   4936 C  CB  . MET B 2 203 ? 164.963 173.579 136.734 1.00 58.68  ? 194 MET A CB  1 
ATOM   4937 C  CG  . MET B 2 203 ? 165.348 172.420 135.847 1.00 57.28  ? 194 MET A CG  1 
ATOM   4938 S  SD  . MET B 2 203 ? 166.947 172.692 135.072 1.00 65.40  ? 194 MET A SD  1 
ATOM   4939 C  CE  . MET B 2 203 ? 166.667 171.962 133.467 1.00 62.31  ? 194 MET A CE  1 
ATOM   4940 N  N   . VAL B 2 204 ? 163.539 175.442 138.785 1.00 63.10  ? 195 VAL A N   1 
ATOM   4941 C  CA  . VAL B 2 204 ? 163.569 176.056 140.107 1.00 60.03  ? 195 VAL A CA  1 
ATOM   4942 C  C   . VAL B 2 204 ? 162.234 175.875 140.818 1.00 61.74  ? 195 VAL A C   1 
ATOM   4943 O  O   . VAL B 2 204 ? 162.189 175.665 142.034 1.00 67.17  ? 195 VAL A O   1 
ATOM   4944 C  CB  . VAL B 2 204 ? 163.966 177.536 139.997 1.00 62.26  ? 195 VAL A CB  1 
ATOM   4945 C  CG1 . VAL B 2 204 ? 163.797 178.227 141.327 1.00 71.72  ? 195 VAL A CG1 1 
ATOM   4946 C  CG2 . VAL B 2 204 ? 165.399 177.651 139.530 1.00 64.54  ? 195 VAL A CG2 1 
ATOM   4947 N  N   . GLN B 2 205 ? 161.126 175.948 140.081 1.00 62.75  ? 196 GLN A N   1 
ATOM   4948 C  CA  . GLN B 2 205 ? 159.822 175.744 140.701 1.00 65.00  ? 196 GLN A CA  1 
ATOM   4949 C  C   . GLN B 2 205 ? 159.663 174.314 141.198 1.00 66.66  ? 196 GLN A C   1 
ATOM   4950 O  O   . GLN B 2 205 ? 159.125 174.088 142.288 1.00 69.28  ? 196 GLN A O   1 
ATOM   4951 C  CB  . GLN B 2 205 ? 158.710 176.104 139.718 1.00 67.92  ? 196 GLN A CB  1 
ATOM   4952 C  CG  . GLN B 2 205 ? 158.653 177.580 139.380 1.00 69.05  ? 196 GLN A CG  1 
ATOM   4953 C  CD  . GLN B 2 205 ? 157.520 178.295 140.068 1.00 75.61  ? 196 GLN A CD  1 
ATOM   4954 O  OE1 . GLN B 2 205 ? 156.793 177.707 140.864 1.00 81.85  ? 196 GLN A OE1 1 
ATOM   4955 N  NE2 . GLN B 2 205 ? 157.364 179.576 139.769 1.00 78.74  ? 196 GLN A NE2 1 
ATOM   4956 N  N   . LEU B 2 206 ? 160.125 173.333 140.418 1.00 65.24  ? 197 LEU A N   1 
ATOM   4957 C  CA  . LEU B 2 206 ? 160.091 171.951 140.885 1.00 66.69  ? 197 LEU A CA  1 
ATOM   4958 C  C   . LEU B 2 206 ? 160.997 171.761 142.093 1.00 70.25  ? 197 LEU A C   1 
ATOM   4959 O  O   . LEU B 2 206 ? 160.667 171.010 143.017 1.00 71.55  ? 197 LEU A O   1 
ATOM   4960 C  CB  . LEU B 2 206 ? 160.496 171.000 139.762 1.00 65.32  ? 197 LEU A CB  1 
ATOM   4961 C  CG  . LEU B 2 206 ? 160.795 169.558 140.165 1.00 61.25  ? 197 LEU A CG  1 
ATOM   4962 C  CD1 . LEU B 2 206 ? 159.516 168.754 140.274 1.00 57.46  ? 197 LEU A CD1 1 
ATOM   4963 C  CD2 . LEU B 2 206 ? 161.741 168.920 139.172 1.00 64.09  ? 197 LEU A CD2 1 
ATOM   4964 N  N   . MET B 2 207 ? 162.147 172.432 142.098 1.00 68.02  ? 198 MET A N   1 
ATOM   4965 C  CA  . MET B 2 207 ? 163.068 172.327 143.223 1.00 63.48  ? 198 MET A CA  1 
ATOM   4966 C  C   . MET B 2 207 ? 162.455 172.900 144.492 1.00 65.18  ? 198 MET A C   1 
ATOM   4967 O  O   . MET B 2 207 ? 162.625 172.343 145.581 1.00 67.01  ? 198 MET A O   1 
ATOM   4968 C  CB  . MET B 2 207 ? 164.368 173.049 142.882 1.00 64.82  ? 198 MET A CB  1 
ATOM   4969 C  CG  . MET B 2 207 ? 165.616 172.245 143.126 1.00 65.04  ? 198 MET A CG  1 
ATOM   4970 S  SD  . MET B 2 207 ? 166.946 172.832 142.070 1.00 61.52  ? 198 MET A SD  1 
ATOM   4971 C  CE  . MET B 2 207 ? 166.373 172.253 140.481 1.00 58.92  ? 198 MET A CE  1 
ATOM   4972 N  N   . LEU B 2 208 ? 161.745 174.020 144.372 1.00 69.24  ? 199 LEU A N   1 
ATOM   4973 C  CA  . LEU B 2 208 ? 161.129 174.637 145.541 1.00 71.95  ? 199 LEU A CA  1 
ATOM   4974 C  C   . LEU B 2 208 ? 159.894 173.876 146.003 1.00 73.16  ? 199 LEU A C   1 
ATOM   4975 O  O   . LEU B 2 208 ? 159.574 173.892 147.195 1.00 74.14  ? 199 LEU A O   1 
ATOM   4976 C  CB  . LEU B 2 208 ? 160.767 176.089 145.238 1.00 74.94  ? 199 LEU A CB  1 
ATOM   4977 C  CG  . LEU B 2 208 ? 161.897 177.110 145.353 1.00 78.43  ? 199 LEU A CG  1 
ATOM   4978 C  CD1 . LEU B 2 208 ? 161.414 178.476 144.904 1.00 79.01  ? 199 LEU A CD1 1 
ATOM   4979 C  CD2 . LEU B 2 208 ? 162.432 177.166 146.775 1.00 72.87  ? 199 LEU A CD2 1 
ATOM   4980 N  N   . HIS B 2 209 ? 159.182 173.219 145.084 1.00 73.71  ? 200 HIS A N   1 
ATOM   4981 C  CA  . HIS B 2 209 ? 157.981 172.488 145.474 1.00 72.88  ? 200 HIS A CA  1 
ATOM   4982 C  C   . HIS B 2 209 ? 158.310 171.338 146.415 1.00 73.33  ? 200 HIS A C   1 
ATOM   4983 O  O   . HIS B 2 209 ? 157.575 171.083 147.374 1.00 78.07  ? 200 HIS A O   1 
ATOM   4984 C  CB  . HIS B 2 209 ? 157.254 171.968 144.238 1.00 72.29  ? 200 HIS A CB  1 
ATOM   4985 C  CG  . HIS B 2 209 ? 155.944 171.313 144.541 1.00 71.99  ? 200 HIS A CG  1 
ATOM   4986 N  ND1 . HIS B 2 209 ? 155.809 169.950 144.683 1.00 71.87  ? 200 HIS A ND1 1 
ATOM   4987 C  CD2 . HIS B 2 209 ? 154.708 171.833 144.719 1.00 72.96  ? 200 HIS A CD2 1 
ATOM   4988 C  CE1 . HIS B 2 209 ? 154.548 169.658 144.940 1.00 73.36  ? 200 HIS A CE1 1 
ATOM   4989 N  NE2 . HIS B 2 209 ? 153.858 170.783 144.967 1.00 73.89  ? 200 HIS A NE2 1 
ATOM   4990 N  N   . PHE B 2 210 ? 159.402 170.626 146.153 1.00 70.15  ? 201 PHE A N   1 
ATOM   4991 C  CA  . PHE B 2 210 ? 159.801 169.493 146.975 1.00 72.00  ? 201 PHE A CA  1 
ATOM   4992 C  C   . PHE B 2 210 ? 160.828 169.865 148.037 1.00 71.75  ? 201 PHE A C   1 
ATOM   4993 O  O   . PHE B 2 210 ? 161.333 168.977 148.728 1.00 72.02  ? 201 PHE A O   1 
ATOM   4994 C  CB  . PHE B 2 210 ? 160.339 168.368 146.089 1.00 70.47  ? 201 PHE A CB  1 
ATOM   4995 C  CG  . PHE B 2 210 ? 159.272 167.647 145.314 1.00 73.10  ? 201 PHE A CG  1 
ATOM   4996 C  CD1 . PHE B 2 210 ? 158.239 167.005 145.967 1.00 72.32  ? 201 PHE A CD1 1 
ATOM   4997 C  CD2 . PHE B 2 210 ? 159.299 167.618 143.935 1.00 71.67  ? 201 PHE A CD2 1 
ATOM   4998 C  CE1 . PHE B 2 210 ? 157.258 166.347 145.260 1.00 67.71  ? 201 PHE A CE1 1 
ATOM   4999 C  CE2 . PHE B 2 210 ? 158.320 166.960 143.226 1.00 68.60  ? 201 PHE A CE2 1 
ATOM   5000 C  CZ  . PHE B 2 210 ? 157.300 166.325 143.891 1.00 69.38  ? 201 PHE A CZ  1 
ATOM   5001 N  N   . ARG B 2 211 ? 161.151 171.151 148.171 1.00 72.82  ? 202 ARG A N   1 
ATOM   5002 C  CA  . ARG B 2 211 ? 162.019 171.663 149.231 1.00 72.77  ? 202 ARG A CA  1 
ATOM   5003 C  C   . ARG B 2 211 ? 163.423 171.059 149.160 1.00 69.91  ? 202 ARG A C   1 
ATOM   5004 O  O   . ARG B 2 211 ? 163.900 170.411 150.091 1.00 74.23  ? 202 ARG A O   1 
ATOM   5005 C  CB  . ARG B 2 211 ? 161.393 171.427 150.609 1.00 75.16  ? 202 ARG A CB  1 
ATOM   5006 C  CG  . ARG B 2 211 ? 160.154 172.253 150.879 1.00 77.93  ? 202 ARG A CG  1 
ATOM   5007 C  CD  . ARG B 2 211 ? 159.233 171.536 151.847 1.00 87.57  ? 202 ARG A CD  1 
ATOM   5008 N  NE  . ARG B 2 211 ? 158.640 170.348 151.245 1.00 91.63  ? 202 ARG A NE  1 
ATOM   5009 C  CZ  . ARG B 2 211 ? 158.154 169.325 151.932 1.00 99.12  ? 202 ARG A CZ  1 
ATOM   5010 N  NH1 . ARG B 2 211 ? 158.176 169.307 153.254 1.00 100.63 ? 202 ARG A NH1 1 
ATOM   5011 N  NH2 . ARG B 2 211 ? 157.631 168.292 151.276 1.00 94.76  ? 202 ARG A NH2 1 
ATOM   5012 N  N   . TRP B 2 212 ? 164.084 171.291 148.032 1.00 66.26  ? 203 TRP A N   1 
ATOM   5013 C  CA  . TRP B 2 212 ? 165.500 170.990 147.871 1.00 64.42  ? 203 TRP A CA  1 
ATOM   5014 C  C   . TRP B 2 212 ? 166.239 172.310 147.727 1.00 64.96  ? 203 TRP A C   1 
ATOM   5015 O  O   . TRP B 2 212 ? 165.958 173.077 146.803 1.00 71.34  ? 203 TRP A O   1 
ATOM   5016 C  CB  . TRP B 2 212 ? 165.755 170.113 146.645 1.00 65.51  ? 203 TRP A CB  1 
ATOM   5017 C  CG  . TRP B 2 212 ? 164.889 168.901 146.542 1.00 67.43  ? 203 TRP A CG  1 
ATOM   5018 C  CD1 . TRP B 2 212 ? 164.361 168.183 147.565 1.00 69.19  ? 203 TRP A CD1 1 
ATOM   5019 C  CD2 . TRP B 2 212 ? 164.445 168.270 145.338 1.00 62.88  ? 203 TRP A CD2 1 
ATOM   5020 N  NE1 . TRP B 2 212 ? 163.615 167.142 147.076 1.00 67.22  ? 203 TRP A NE1 1 
ATOM   5021 C  CE2 . TRP B 2 212 ? 163.652 167.175 145.709 1.00 61.83  ? 203 TRP A CE2 1 
ATOM   5022 C  CE3 . TRP B 2 212 ? 164.639 168.530 143.981 1.00 63.54  ? 203 TRP A CE3 1 
ATOM   5023 C  CZ2 . TRP B 2 212 ? 163.055 166.341 144.776 1.00 61.31  ? 203 TRP A CZ2 1 
ATOM   5024 C  CZ3 . TRP B 2 212 ? 164.047 167.700 143.058 1.00 62.84  ? 203 TRP A CZ3 1 
ATOM   5025 C  CH2 . TRP B 2 212 ? 163.266 166.618 143.458 1.00 63.13  ? 203 TRP A CH2 1 
ATOM   5026 N  N   . ASN B 2 213 ? 167.181 172.575 148.627 1.00 64.05  ? 204 ASN A N   1 
ATOM   5027 C  CA  . ASN B 2 213 ? 167.980 173.790 148.529 1.00 68.28  ? 204 ASN A CA  1 
ATOM   5028 C  C   . ASN B 2 213 ? 169.465 173.468 148.544 1.00 71.53  ? 204 ASN A C   1 
ATOM   5029 O  O   . ASN B 2 213 ? 170.274 174.259 149.031 1.00 79.55  ? 204 ASN A O   1 
ATOM   5030 C  CB  . ASN B 2 213 ? 167.634 174.781 149.640 1.00 74.02  ? 204 ASN A CB  1 
ATOM   5031 C  CG  . ASN B 2 213 ? 167.774 174.190 151.021 1.00 76.37  ? 204 ASN A CG  1 
ATOM   5032 O  OD1 . ASN B 2 213 ? 168.871 173.845 151.455 1.00 80.11  ? 204 ASN A OD1 1 
ATOM   5033 N  ND2 . ASN B 2 213 ? 166.661 174.090 151.733 1.00 79.79  ? 204 ASN A ND2 1 
ATOM   5034 N  N   . TRP B 2 214 ? 169.838 172.310 148.010 1.00 67.67  ? 205 TRP A N   1 
ATOM   5035 C  CA  . TRP B 2 214 ? 171.236 171.895 147.975 1.00 67.77  ? 205 TRP A CA  1 
ATOM   5036 C  C   . TRP B 2 214 ? 171.390 170.994 146.756 1.00 67.78  ? 205 TRP A C   1 
ATOM   5037 O  O   . TRP B 2 214 ? 171.056 169.808 146.816 1.00 71.84  ? 205 TRP A O   1 
ATOM   5038 C  CB  . TRP B 2 214 ? 171.619 171.178 149.261 1.00 73.79  ? 205 TRP A CB  1 
ATOM   5039 C  CG  . TRP B 2 214 ? 173.082 171.038 149.474 1.00 76.08  ? 205 TRP A CG  1 
ATOM   5040 C  CD1 . TRP B 2 214 ? 173.774 169.880 149.623 1.00 75.25  ? 205 TRP A CD1 1 
ATOM   5041 C  CD2 . TRP B 2 214 ? 174.038 172.095 149.584 1.00 78.42  ? 205 TRP A CD2 1 
ATOM   5042 N  NE1 . TRP B 2 214 ? 175.105 170.144 149.804 1.00 78.56  ? 205 TRP A NE1 1 
ATOM   5043 C  CE2 . TRP B 2 214 ? 175.293 171.499 149.788 1.00 79.38  ? 205 TRP A CE2 1 
ATOM   5044 C  CE3 . TRP B 2 214 ? 173.955 173.486 149.531 1.00 78.91  ? 205 TRP A CE3 1 
ATOM   5045 C  CZ2 . TRP B 2 214 ? 176.453 172.244 149.933 1.00 80.90  ? 205 TRP A CZ2 1 
ATOM   5046 C  CZ3 . TRP B 2 214 ? 175.107 174.222 149.675 1.00 84.02  ? 205 TRP A CZ3 1 
ATOM   5047 C  CH2 . TRP B 2 214 ? 176.340 173.602 149.873 1.00 83.63  ? 205 TRP A CH2 1 
ATOM   5048 N  N   . ILE B 2 215 ? 171.894 171.557 145.658 1.00 63.91  ? 206 ILE A N   1 
ATOM   5049 C  CA  . ILE B 2 215 ? 171.933 170.863 144.381 1.00 57.81  ? 206 ILE A CA  1 
ATOM   5050 C  C   . ILE B 2 215 ? 173.353 170.865 143.837 1.00 58.07  ? 206 ILE A C   1 
ATOM   5051 O  O   . ILE B 2 215 ? 174.195 171.672 144.226 1.00 64.37  ? 206 ILE A O   1 
ATOM   5052 C  CB  . ILE B 2 215 ? 170.973 171.492 143.355 1.00 53.03  ? 206 ILE A CB  1 
ATOM   5053 C  CG1 . ILE B 2 215 ? 171.465 172.875 142.950 1.00 53.58  ? 206 ILE A CG1 1 
ATOM   5054 C  CG2 . ILE B 2 215 ? 169.587 171.593 143.926 1.00 58.42  ? 206 ILE A CG2 1 
ATOM   5055 C  CD1 . ILE B 2 215 ? 170.862 173.372 141.669 1.00 53.69  ? 206 ILE A CD1 1 
ATOM   5056 N  N   . ILE B 2 216 ? 173.605 169.933 142.925 1.00 53.00  ? 207 ILE A N   1 
ATOM   5057 C  CA  . ILE B 2 216 ? 174.872 169.815 142.217 1.00 50.93  ? 207 ILE A CA  1 
ATOM   5058 C  C   . ILE B 2 216 ? 174.597 170.053 140.743 1.00 53.32  ? 207 ILE A C   1 
ATOM   5059 O  O   . ILE B 2 216 ? 173.714 169.412 140.165 1.00 60.72  ? 207 ILE A O   1 
ATOM   5060 C  CB  . ILE B 2 216 ? 175.508 168.433 142.430 1.00 54.86  ? 207 ILE A CB  1 
ATOM   5061 C  CG1 . ILE B 2 216 ? 175.983 168.273 143.871 1.00 65.12  ? 207 ILE A CG1 1 
ATOM   5062 C  CG2 . ILE B 2 216 ? 176.643 168.221 141.458 1.00 56.00  ? 207 ILE A CG2 1 
ATOM   5063 C  CD1 . ILE B 2 216 ? 176.195 166.840 144.280 1.00 65.66  ? 207 ILE A CD1 1 
ATOM   5064 N  N   . VAL B 2 217 ? 175.346 170.961 140.132 1.00 53.29  ? 208 VAL A N   1 
ATOM   5065 C  CA  . VAL B 2 217 ? 175.140 171.338 138.740 1.00 53.57  ? 208 VAL A CA  1 
ATOM   5066 C  C   . VAL B 2 217 ? 176.304 170.816 137.919 1.00 57.63  ? 208 VAL A C   1 
ATOM   5067 O  O   . VAL B 2 217 ? 177.467 171.023 138.281 1.00 67.09  ? 208 VAL A O   1 
ATOM   5068 C  CB  . VAL B 2 217 ? 175.001 172.859 138.580 1.00 55.34  ? 208 VAL A CB  1 
ATOM   5069 C  CG1 . VAL B 2 217 ? 175.009 173.230 137.117 1.00 54.84  ? 208 VAL A CG1 1 
ATOM   5070 C  CG2 . VAL B 2 217 ? 173.730 173.336 139.237 1.00 58.74  ? 208 VAL A CG2 1 
ATOM   5071 N  N   . LEU B 2 218 ? 175.995 170.135 136.824 1.00 57.10  ? 209 LEU A N   1 
ATOM   5072 C  CA  . LEU B 2 218 ? 176.996 169.654 135.886 1.00 60.50  ? 209 LEU A CA  1 
ATOM   5073 C  C   . LEU B 2 218 ? 176.704 170.247 134.519 1.00 61.66  ? 209 LEU A C   1 
ATOM   5074 O  O   . LEU B 2 218 ? 175.563 170.203 134.053 1.00 62.75  ? 209 LEU A O   1 
ATOM   5075 C  CB  . LEU B 2 218 ? 176.999 168.128 135.813 1.00 60.31  ? 209 LEU A CB  1 
ATOM   5076 C  CG  . LEU B 2 218 ? 177.428 167.397 137.080 1.00 62.44  ? 209 LEU A CG  1 
ATOM   5077 C  CD1 . LEU B 2 218 ? 177.259 165.903 136.912 1.00 64.82  ? 209 LEU A CD1 1 
ATOM   5078 C  CD2 . LEU B 2 218 ? 178.861 167.738 137.409 1.00 67.33  ? 209 LEU A CD2 1 
ATOM   5079 N  N   . VAL B 2 219 ? 177.727 170.806 133.882 1.00 65.10  ? 210 VAL A N   1 
ATOM   5080 C  CA  . VAL B 2 219 ? 177.600 171.360 132.545 1.00 69.51  ? 210 VAL A CA  1 
ATOM   5081 C  C   . VAL B 2 219 ? 178.604 170.660 131.642 1.00 74.56  ? 210 VAL A C   1 
ATOM   5082 O  O   . VAL B 2 219 ? 179.548 170.022 132.101 1.00 79.61  ? 210 VAL A O   1 
ATOM   5083 C  CB  . VAL B 2 219 ? 177.813 172.884 132.515 1.00 73.12  ? 210 VAL A CB  1 
ATOM   5084 C  CG1 . VAL B 2 219 ? 176.907 173.566 133.514 1.00 73.51  ? 210 VAL A CG1 1 
ATOM   5085 C  CG2 . VAL B 2 219 ? 179.263 173.218 132.791 1.00 74.52  ? 210 VAL A CG2 1 
ATOM   5086 N  N   . SER B 2 220 ? 178.384 170.782 130.343 1.00 74.07  ? 211 SER A N   1 
ATOM   5087 C  CA  . SER B 2 220 ? 179.309 170.253 129.356 1.00 79.93  ? 211 SER A CA  1 
ATOM   5088 C  C   . SER B 2 220 ? 180.264 171.349 128.909 1.00 90.94  ? 211 SER A C   1 
ATOM   5089 O  O   . SER B 2 220 ? 180.048 172.535 129.162 1.00 93.65  ? 211 SER A O   1 
ATOM   5090 C  CB  . SER B 2 220 ? 178.558 169.682 128.156 1.00 81.36  ? 211 SER A CB  1 
ATOM   5091 O  OG  . SER B 2 220 ? 177.478 170.523 127.798 1.00 85.43  ? 211 SER A OG  1 
ATOM   5092 N  N   . SER B 2 221 ? 181.337 170.936 128.238 1.00 95.22  ? 212 SER A N   1 
ATOM   5093 C  CA  . SER B 2 221 ? 182.356 171.892 127.828 1.00 94.61  ? 212 SER A CA  1 
ATOM   5094 C  C   . SER B 2 221 ? 181.878 172.814 126.716 1.00 91.14  ? 212 SER A C   1 
ATOM   5095 O  O   . SER B 2 221 ? 182.502 173.852 126.481 1.00 89.80  ? 212 SER A O   1 
ATOM   5096 C  CB  . SER B 2 221 ? 183.613 171.154 127.382 1.00 94.42  ? 212 SER A CB  1 
ATOM   5097 O  OG  . SER B 2 221 ? 183.998 170.192 128.345 1.00 93.25  ? 212 SER A OG  1 
ATOM   5098 N  N   . ASP B 2 222 ? 180.793 172.466 126.031 1.00 90.52  ? 213 ASP A N   1 
ATOM   5099 C  CA  . ASP B 2 222 ? 180.322 173.284 124.928 1.00 92.64  ? 213 ASP A CA  1 
ATOM   5100 C  C   . ASP B 2 222 ? 179.639 174.545 125.450 1.00 91.08  ? 213 ASP A C   1 
ATOM   5101 O  O   . ASP B 2 222 ? 179.394 174.709 126.647 1.00 87.23  ? 213 ASP A O   1 
ATOM   5102 C  CB  . ASP B 2 222 ? 179.372 172.488 124.035 1.00 95.72  ? 213 ASP A CB  1 
ATOM   5103 C  CG  . ASP B 2 222 ? 178.406 171.638 124.825 1.00 95.67  ? 213 ASP A CG  1 
ATOM   5104 O  OD1 . ASP B 2 222 ? 177.464 172.203 125.416 1.00 94.10  ? 213 ASP A OD1 1 
ATOM   5105 O  OD2 . ASP B 2 222 ? 178.585 170.404 124.848 1.00 94.12  ? 213 ASP A OD2 1 
ATOM   5106 N  N   . THR B 2 223 ? 179.342 175.454 124.521 1.00 93.74  ? 214 THR A N   1 
ATOM   5107 C  CA  . THR B 2 223 ? 178.771 176.743 124.896 1.00 94.69  ? 214 THR A CA  1 
ATOM   5108 C  C   . THR B 2 223 ? 177.379 176.588 125.492 1.00 94.27  ? 214 THR A C   1 
ATOM   5109 O  O   . THR B 2 223 ? 177.016 177.317 126.420 1.00 95.36  ? 214 THR A O   1 
ATOM   5110 C  CB  . THR B 2 223 ? 178.728 177.674 123.686 1.00 95.15  ? 214 THR A CB  1 
ATOM   5111 O  OG1 . THR B 2 223 ? 177.497 177.486 122.978 1.00 95.15  ? 214 THR A OG1 1 
ATOM   5112 C  CG2 . THR B 2 223 ? 179.890 177.384 122.754 1.00 92.31  ? 214 THR A CG2 1 
ATOM   5113 N  N   . TYR B 2 224 ? 176.580 175.660 124.965 1.00 91.13  ? 215 TYR A N   1 
ATOM   5114 C  CA  . TYR B 2 224 ? 175.207 175.520 125.437 1.00 92.06  ? 215 TYR A CA  1 
ATOM   5115 C  C   . TYR B 2 224 ? 175.170 175.154 126.913 1.00 93.57  ? 215 TYR A C   1 
ATOM   5116 O  O   . TYR B 2 224 ? 174.421 175.751 127.698 1.00 93.84  ? 215 TYR A O   1 
ATOM   5117 C  CB  . TYR B 2 224 ? 174.477 174.468 124.610 1.00 90.02  ? 215 TYR A CB  1 
ATOM   5118 C  CG  . TYR B 2 224 ? 173.391 173.750 125.369 1.00 89.67  ? 215 TYR A CG  1 
ATOM   5119 C  CD1 . TYR B 2 224 ? 172.199 174.386 125.673 1.00 86.79  ? 215 TYR A CD1 1 
ATOM   5120 C  CD2 . TYR B 2 224 ? 173.552 172.437 125.773 1.00 86.25  ? 215 TYR A CD2 1 
ATOM   5121 C  CE1 . TYR B 2 224 ? 171.205 173.739 126.360 1.00 85.88  ? 215 TYR A CE1 1 
ATOM   5122 C  CE2 . TYR B 2 224 ? 172.560 171.782 126.460 1.00 85.17  ? 215 TYR A CE2 1 
ATOM   5123 C  CZ  . TYR B 2 224 ? 171.389 172.438 126.749 1.00 85.22  ? 215 TYR A CZ  1 
ATOM   5124 O  OH  . TYR B 2 224 ? 170.396 171.791 127.436 1.00 85.19  ? 215 TYR A OH  1 
ATOM   5125 N  N   . GLY B 2 225 ? 175.980 174.175 127.310 1.00 90.74  ? 216 GLY A N   1 
ATOM   5126 C  CA  . GLY B 2 225 ? 176.027 173.796 128.709 1.00 87.02  ? 216 GLY A CA  1 
ATOM   5127 C  C   . GLY B 2 225 ? 176.497 174.928 129.598 1.00 87.50  ? 216 GLY A C   1 
ATOM   5128 O  O   . GLY B 2 225 ? 175.953 175.143 130.681 1.00 88.73  ? 216 GLY A O   1 
ATOM   5129 N  N   . ARG B 2 226 ? 177.504 175.676 129.146 1.00 87.88  ? 217 ARG A N   1 
ATOM   5130 C  CA  . ARG B 2 226 ? 178.029 176.772 129.953 1.00 88.38  ? 217 ARG A CA  1 
ATOM   5131 C  C   . ARG B 2 226 ? 176.985 177.866 130.142 1.00 90.12  ? 217 ARG A C   1 
ATOM   5132 O  O   . ARG B 2 226 ? 176.773 178.350 131.261 1.00 93.15  ? 217 ARG A O   1 
ATOM   5133 C  CB  . ARG B 2 226 ? 179.297 177.333 129.311 1.00 85.30  ? 217 ARG A CB  1 
ATOM   5134 C  CG  . ARG B 2 226 ? 179.509 178.810 129.555 1.00 84.84  ? 217 ARG A CG  1 
ATOM   5135 C  CD  . ARG B 2 226 ? 180.858 179.263 129.038 1.00 91.09  ? 217 ARG A CD  1 
ATOM   5136 N  NE  . ARG B 2 226 ? 180.877 179.384 127.586 1.00 95.70  ? 217 ARG A NE  1 
ATOM   5137 C  CZ  . ARG B 2 226 ? 180.320 180.378 126.909 1.00 98.01  ? 217 ARG A CZ  1 
ATOM   5138 N  NH1 . ARG B 2 226 ? 179.686 181.363 127.523 1.00 99.73  ? 217 ARG A NH1 1 
ATOM   5139 N  NH2 . ARG B 2 226 ? 180.402 180.385 125.583 1.00 97.71  ? 217 ARG A NH2 1 
ATOM   5140 N  N   . ASP B 2 227 ? 176.317 178.267 129.057 1.00 87.20  ? 218 ASP A N   1 
ATOM   5141 C  CA  . ASP B 2 227 ? 175.295 179.302 129.171 1.00 88.03  ? 218 ASP A CA  1 
ATOM   5142 C  C   . ASP B 2 227 ? 174.146 178.844 130.054 1.00 89.25  ? 218 ASP A C   1 
ATOM   5143 O  O   . ASP B 2 227 ? 173.662 179.608 130.896 1.00 89.57  ? 218 ASP A O   1 
ATOM   5144 C  CB  . ASP B 2 227 ? 174.768 179.702 127.792 1.00 91.14  ? 218 ASP A CB  1 
ATOM   5145 C  CG  . ASP B 2 227 ? 175.860 180.180 126.861 1.00 98.57  ? 218 ASP A CG  1 
ATOM   5146 O  OD1 . ASP B 2 227 ? 176.631 181.079 127.256 1.00 104.86 ? 218 ASP A OD1 1 
ATOM   5147 O  OD2 . ASP B 2 227 ? 175.931 179.679 125.720 1.00 99.76  ? 218 ASP A OD2 1 
ATOM   5148 N  N   . ASN B 2 228 ? 173.694 177.601 129.882 1.00 87.52  ? 219 ASN A N   1 
ATOM   5149 C  CA  . ASN B 2 228 ? 172.581 177.123 130.692 1.00 85.57  ? 219 ASN A CA  1 
ATOM   5150 C  C   . ASN B 2 228 ? 172.968 177.020 132.162 1.00 84.30  ? 219 ASN A C   1 
ATOM   5151 O  O   . ASN B 2 228 ? 172.170 177.362 133.040 1.00 83.65  ? 219 ASN A O   1 
ATOM   5152 C  CB  . ASN B 2 228 ? 172.086 175.783 130.160 1.00 84.12  ? 219 ASN A CB  1 
ATOM   5153 C  CG  . ASN B 2 228 ? 170.928 175.940 129.203 1.00 84.97  ? 219 ASN A CG  1 
ATOM   5154 O  OD1 . ASN B 2 228 ? 171.069 176.532 128.135 1.00 87.22  ? 219 ASN A OD1 1 
ATOM   5155 N  ND2 . ASN B 2 228 ? 169.771 175.417 129.584 1.00 84.05  ? 219 ASN A ND2 1 
ATOM   5156 N  N   . GLY B 2 229 ? 174.184 176.558 132.454 1.00 84.37  ? 220 GLY A N   1 
ATOM   5157 C  CA  . GLY B 2 229 ? 174.618 176.483 133.837 1.00 79.70  ? 220 GLY A CA  1 
ATOM   5158 C  C   . GLY B 2 229 ? 174.741 177.847 134.484 1.00 81.63  ? 220 GLY A C   1 
ATOM   5159 O  O   . GLY B 2 229 ? 174.331 178.040 135.630 1.00 83.85  ? 220 GLY A O   1 
ATOM   5160 N  N   . GLN B 2 230 ? 175.303 178.815 133.757 1.00 83.36  ? 221 GLN A N   1 
ATOM   5161 C  CA  . GLN B 2 230 ? 175.388 180.172 134.286 1.00 86.39  ? 221 GLN A CA  1 
ATOM   5162 C  C   . GLN B 2 230 ? 173.999 180.744 134.529 1.00 86.61  ? 221 GLN A C   1 
ATOM   5163 O  O   . GLN B 2 230 ? 173.753 181.378 135.562 1.00 86.96  ? 221 GLN A O   1 
ATOM   5164 C  CB  . GLN B 2 230 ? 176.201 181.047 133.325 1.00 89.98  ? 221 GLN A CB  1 
ATOM   5165 C  CG  . GLN B 2 230 ? 176.882 182.278 133.937 1.00 90.54  ? 221 GLN A CG  1 
ATOM   5166 C  CD  . GLN B 2 230 ? 175.928 183.381 134.368 1.00 96.24  ? 221 GLN A CD  1 
ATOM   5167 O  OE1 . GLN B 2 230 ? 174.748 183.376 134.029 1.00 98.60  ? 221 GLN A OE1 1 
ATOM   5168 N  NE2 . GLN B 2 230 ? 176.445 184.334 135.134 1.00 93.87  ? 221 GLN A NE2 1 
ATOM   5169 N  N   . LEU B 2 231 ? 173.075 180.519 133.594 1.00 85.21  ? 222 LEU A N   1 
ATOM   5170 C  CA  . LEU B 2 231 ? 171.717 181.022 133.764 1.00 85.36  ? 222 LEU A CA  1 
ATOM   5171 C  C   . LEU B 2 231 ? 171.038 180.391 134.971 1.00 82.45  ? 222 LEU A C   1 
ATOM   5172 O  O   . LEU B 2 231 ? 170.367 181.083 135.745 1.00 83.49  ? 222 LEU A O   1 
ATOM   5173 C  CB  . LEU B 2 231 ? 170.900 180.768 132.501 1.00 83.32  ? 222 LEU A CB  1 
ATOM   5174 C  CG  . LEU B 2 231 ? 169.469 181.284 132.568 1.00 81.28  ? 222 LEU A CG  1 
ATOM   5175 C  CD1 . LEU B 2 231 ? 169.466 182.792 132.709 1.00 85.07  ? 222 LEU A CD1 1 
ATOM   5176 C  CD2 . LEU B 2 231 ? 168.708 180.865 131.332 1.00 81.39  ? 222 LEU A CD2 1 
ATOM   5177 N  N   . LEU B 2 232 ? 171.196 179.079 135.150 1.00 79.94  ? 223 LEU A N   1 
ATOM   5178 C  CA  . LEU B 2 232 ? 170.600 178.430 136.310 1.00 76.63  ? 223 LEU A CA  1 
ATOM   5179 C  C   . LEU B 2 232 ? 171.201 178.959 137.599 1.00 77.41  ? 223 LEU A C   1 
ATOM   5180 O  O   . LEU B 2 232 ? 170.480 179.199 138.569 1.00 81.69  ? 223 LEU A O   1 
ATOM   5181 C  CB  . LEU B 2 232 ? 170.768 176.915 136.233 1.00 72.65  ? 223 LEU A CB  1 
ATOM   5182 C  CG  . LEU B 2 232 ? 170.374 176.194 137.522 1.00 65.48  ? 223 LEU A CG  1 
ATOM   5183 C  CD1 . LEU B 2 232 ? 168.875 176.209 137.711 1.00 63.43  ? 223 LEU A CD1 1 
ATOM   5184 C  CD2 . LEU B 2 232 ? 170.886 174.776 137.518 1.00 61.46  ? 223 LEU A CD2 1 
ATOM   5185 N  N   . GLY B 2 233 ? 172.520 179.149 137.633 1.00 74.24  ? 224 GLY A N   1 
ATOM   5186 C  CA  . GLY B 2 233 ? 173.137 179.693 138.830 1.00 73.83  ? 224 GLY A CA  1 
ATOM   5187 C  C   . GLY B 2 233 ? 172.614 181.074 139.169 1.00 83.52  ? 224 GLY A C   1 
ATOM   5188 O  O   . GLY B 2 233 ? 172.271 181.354 140.322 1.00 87.39  ? 224 GLY A O   1 
ATOM   5189 N  N   . GLU B 2 234 ? 172.521 181.947 138.165 1.00 86.15  ? 225 GLU A N   1 
ATOM   5190 C  CA  . GLU B 2 234 ? 172.022 183.298 138.401 1.00 85.39  ? 225 GLU A CA  1 
ATOM   5191 C  C   . GLU B 2 234 ? 170.571 183.280 138.863 1.00 85.82  ? 225 GLU A C   1 
ATOM   5192 O  O   . GLU B 2 234 ? 170.192 184.037 139.763 1.00 86.46  ? 225 GLU A O   1 
ATOM   5193 C  CB  . GLU B 2 234 ? 172.174 184.145 137.138 1.00 84.69  ? 225 GLU A CB  1 
ATOM   5194 C  CG  . GLU B 2 234 ? 171.530 185.518 137.228 1.00 87.41  ? 225 GLU A CG  1 
ATOM   5195 C  CD  . GLU B 2 234 ? 170.176 185.578 136.548 1.00 90.34  ? 225 GLU A CD  1 
ATOM   5196 O  OE1 . GLU B 2 234 ? 169.760 184.558 135.964 1.00 87.61  ? 225 GLU A OE1 1 
ATOM   5197 O  OE2 . GLU B 2 234 ? 169.528 186.645 136.596 1.00 94.93  ? 225 GLU A OE2 1 
ATOM   5198 N  N   . ARG B 2 235 ? 169.742 182.428 138.258 1.00 83.72  ? 226 ARG A N   1 
ATOM   5199 C  CA  . ARG B 2 235 ? 168.340 182.375 138.652 1.00 81.86  ? 226 ARG A CA  1 
ATOM   5200 C  C   . ARG B 2 235 ? 168.180 181.806 140.053 1.00 83.94  ? 226 ARG A C   1 
ATOM   5201 O  O   . ARG B 2 235 ? 167.338 182.271 140.827 1.00 90.11  ? 226 ARG A O   1 
ATOM   5202 C  CB  . ARG B 2 235 ? 167.540 181.546 137.652 1.00 81.27  ? 226 ARG A CB  1 
ATOM   5203 C  CG  . ARG B 2 235 ? 166.105 181.289 138.069 1.00 84.23  ? 226 ARG A CG  1 
ATOM   5204 C  CD  . ARG B 2 235 ? 165.144 181.464 136.905 1.00 80.99  ? 226 ARG A CD  1 
ATOM   5205 N  NE  . ARG B 2 235 ? 165.189 182.808 136.345 1.00 80.20  ? 226 ARG A NE  1 
ATOM   5206 C  CZ  . ARG B 2 235 ? 165.803 183.123 135.214 1.00 79.77  ? 226 ARG A CZ  1 
ATOM   5207 N  NH1 . ARG B 2 235 ? 166.439 182.212 134.498 1.00 79.80  ? 226 ARG A NH1 1 
ATOM   5208 N  NH2 . ARG B 2 235 ? 165.779 184.382 134.791 1.00 80.98  ? 226 ARG A NH2 1 
ATOM   5209 N  N   . VAL B 2 236 ? 168.989 180.810 140.407 1.00 83.61  ? 227 VAL A N   1 
ATOM   5210 C  CA  . VAL B 2 236 ? 168.775 180.099 141.658 1.00 84.34  ? 227 VAL A CA  1 
ATOM   5211 C  C   . VAL B 2 236 ? 169.419 180.815 142.833 1.00 87.11  ? 227 VAL A C   1 
ATOM   5212 O  O   . VAL B 2 236 ? 169.014 180.593 143.979 1.00 84.44  ? 227 VAL A O   1 
ATOM   5213 C  CB  . VAL B 2 236 ? 169.323 178.666 141.548 1.00 81.89  ? 227 VAL A CB  1 
ATOM   5214 C  CG1 . VAL B 2 236 ? 170.845 178.660 141.627 1.00 78.75  ? 227 VAL A CG1 1 
ATOM   5215 C  CG2 . VAL B 2 236 ? 168.706 177.772 142.585 1.00 81.37  ? 227 VAL A CG2 1 
ATOM   5216 N  N   . ALA B 2 237 ? 170.400 181.687 142.583 1.00 92.71  ? 228 ALA A N   1 
ATOM   5217 C  CA  . ALA B 2 237 ? 171.088 182.354 143.679 1.00 94.47  ? 228 ALA A CA  1 
ATOM   5218 C  C   . ALA B 2 237 ? 170.200 183.339 144.425 1.00 95.03  ? 228 ALA A C   1 
ATOM   5219 O  O   . ALA B 2 237 ? 170.525 183.707 145.557 1.00 99.66  ? 228 ALA A O   1 
ATOM   5220 C  CB  . ALA B 2 237 ? 172.329 183.078 143.157 1.00 90.60  ? 228 ALA A CB  1 
ATOM   5221 N  N   . ARG B 2 238 ? 169.098 183.782 143.828 1.00 92.15  ? 229 ARG A N   1 
ATOM   5222 C  CA  . ARG B 2 238 ? 168.236 184.762 144.472 1.00 93.03  ? 229 ARG A CA  1 
ATOM   5223 C  C   . ARG B 2 238 ? 166.988 184.143 145.087 1.00 96.80  ? 229 ARG A C   1 
ATOM   5224 O  O   . ARG B 2 238 ? 166.151 184.874 145.625 1.00 101.22 ? 229 ARG A O   1 
ATOM   5225 C  CB  . ARG B 2 238 ? 167.846 185.867 143.483 1.00 94.90  ? 229 ARG A CB  1 
ATOM   5226 C  CG  . ARG B 2 238 ? 166.656 185.565 142.579 1.00 96.38  ? 229 ARG A CG  1 
ATOM   5227 C  CD  . ARG B 2 238 ? 166.907 186.059 141.161 1.00 98.21  ? 229 ARG A CD  1 
ATOM   5228 N  NE  . ARG B 2 238 ? 165.672 186.243 140.404 1.00 108.17 ? 229 ARG A NE  1 
ATOM   5229 C  CZ  . ARG B 2 238 ? 165.088 185.305 139.672 1.00 103.13 ? 229 ARG A CZ  1 
ATOM   5230 N  NH1 . ARG B 2 238 ? 165.602 184.095 139.565 1.00 96.96  ? 229 ARG A NH1 1 
ATOM   5231 N  NH2 . ARG B 2 238 ? 163.960 185.593 139.026 1.00 100.51 ? 229 ARG A NH2 1 
ATOM   5232 N  N   . ARG B 2 239 ? 166.852 182.817 145.049 1.00 92.20  ? 230 ARG A N   1 
ATOM   5233 C  CA  . ARG B 2 239 ? 165.655 182.152 145.549 1.00 91.30  ? 230 ARG A CA  1 
ATOM   5234 C  C   . ARG B 2 239 ? 165.966 181.195 146.695 1.00 91.40  ? 230 ARG A C   1 
ATOM   5235 O  O   . ARG B 2 239 ? 165.285 180.184 146.866 1.00 91.12  ? 230 ARG A O   1 
ATOM   5236 C  CB  . ARG B 2 239 ? 164.934 181.418 144.422 1.00 85.94  ? 230 ARG A CB  1 
ATOM   5237 C  CG  . ARG B 2 239 ? 163.630 182.069 144.017 1.00 90.43  ? 230 ARG A CG  1 
ATOM   5238 C  CD  . ARG B 2 239 ? 163.117 181.509 142.708 1.00 97.93  ? 230 ARG A CD  1 
ATOM   5239 N  NE  . ARG B 2 239 ? 162.264 182.461 142.008 1.00 102.60 ? 230 ARG A NE  1 
ATOM   5240 C  CZ  . ARG B 2 239 ? 160.978 182.650 142.270 1.00 101.35 ? 230 ARG A CZ  1 
ATOM   5241 N  NH1 . ARG B 2 239 ? 160.357 181.964 143.215 1.00 99.83  ? 230 ARG A NH1 1 
ATOM   5242 N  NH2 . ARG B 2 239 ? 160.299 183.553 141.568 1.00 96.10  ? 230 ARG A NH2 1 
ATOM   5243 N  N   . ASP B 2 240 ? 166.990 181.509 147.487 1.00 90.75  ? 231 ASP A N   1 
ATOM   5244 C  CA  . ASP B 2 240 ? 167.312 180.763 148.705 1.00 89.65  ? 231 ASP A CA  1 
ATOM   5245 C  C   . ASP B 2 240 ? 167.562 179.284 148.421 1.00 84.12  ? 231 ASP A C   1 
ATOM   5246 O  O   . ASP B 2 240 ? 167.145 178.411 149.182 1.00 83.00  ? 231 ASP A O   1 
ATOM   5247 C  CB  . ASP B 2 240 ? 166.216 180.928 149.758 1.00 95.31  ? 231 ASP A CB  1 
ATOM   5248 C  CG  . ASP B 2 240 ? 166.466 182.104 150.682 1.00 101.88 ? 231 ASP A CG  1 
ATOM   5249 O  OD1 . ASP B 2 240 ? 167.460 182.070 151.436 1.00 102.48 ? 231 ASP A OD1 1 
ATOM   5250 O  OD2 . ASP B 2 240 ? 165.663 183.061 150.657 1.00 104.41 ? 231 ASP A OD2 1 
ATOM   5251 N  N   . ILE B 2 241 ? 168.236 178.998 147.311 1.00 83.84  ? 232 ILE A N   1 
ATOM   5252 C  CA  . ILE B 2 241 ? 168.707 177.655 146.992 1.00 80.49  ? 232 ILE A CA  1 
ATOM   5253 C  C   . ILE B 2 241 ? 170.167 177.768 146.585 1.00 80.83  ? 232 ILE A C   1 
ATOM   5254 O  O   . ILE B 2 241 ? 170.503 178.539 145.680 1.00 85.82  ? 232 ILE A O   1 
ATOM   5255 C  CB  . ILE B 2 241 ? 167.888 176.995 145.872 1.00 77.78  ? 232 ILE A CB  1 
ATOM   5256 C  CG1 . ILE B 2 241 ? 166.449 176.751 146.313 1.00 79.89  ? 232 ILE A CG1 1 
ATOM   5257 C  CG2 . ILE B 2 241 ? 168.524 175.690 145.459 1.00 71.48  ? 232 ILE A CG2 1 
ATOM   5258 C  CD1 . ILE B 2 241 ? 165.589 176.161 145.224 1.00 68.60  ? 232 ILE A CD1 1 
ATOM   5259 N  N   . CYS B 2 242 ? 171.029 177.004 147.239 1.00 79.62  ? 233 CYS A N   1 
ATOM   5260 C  CA  . CYS B 2 242 ? 172.460 177.089 147.003 1.00 80.88  ? 233 CYS A CA  1 
ATOM   5261 C  C   . CYS B 2 242 ? 172.935 175.938 146.128 1.00 76.53  ? 233 CYS A C   1 
ATOM   5262 O  O   . CYS B 2 242 ? 172.311 174.878 146.059 1.00 76.46  ? 233 CYS A O   1 
ATOM   5263 C  CB  . CYS B 2 242 ? 173.223 177.090 148.328 1.00 88.14  ? 233 CYS A CB  1 
ATOM   5264 S  SG  . CYS B 2 242 ? 172.316 177.836 149.696 1.00 102.76 ? 233 CYS A SG  1 
ATOM   5265 N  N   . ILE B 2 243 ? 174.062 176.164 145.460 1.00 75.06  ? 234 ILE A N   1 
ATOM   5266 C  CA  . ILE B 2 243 ? 174.699 175.172 144.604 1.00 67.52  ? 234 ILE A CA  1 
ATOM   5267 C  C   . ILE B 2 243 ? 175.920 174.647 145.338 1.00 71.01  ? 234 ILE A C   1 
ATOM   5268 O  O   . ILE B 2 243 ? 176.803 175.424 145.719 1.00 81.03  ? 234 ILE A O   1 
ATOM   5269 C  CB  . ILE B 2 243 ? 175.092 175.764 143.243 1.00 65.00  ? 234 ILE A CB  1 
ATOM   5270 C  CG1 . ILE B 2 243 ? 173.879 175.854 142.322 1.00 68.75  ? 234 ILE A CG1 1 
ATOM   5271 C  CG2 . ILE B 2 243 ? 176.182 174.937 142.597 1.00 63.96  ? 234 ILE A CG2 1 
ATOM   5272 C  CD1 . ILE B 2 243 ? 174.177 176.527 141.011 1.00 67.40  ? 234 ILE A CD1 1 
ATOM   5273 N  N   . ALA B 2 244 ? 175.970 173.331 145.546 1.00 66.83  ? 235 ALA A N   1 
ATOM   5274 C  CA  . ALA B 2 244 ? 177.110 172.737 146.233 1.00 70.54  ? 235 ALA A CA  1 
ATOM   5275 C  C   . ALA B 2 244 ? 178.390 172.930 145.434 1.00 71.04  ? 235 ALA A C   1 
ATOM   5276 O  O   . ALA B 2 244 ? 179.393 173.424 145.958 1.00 74.16  ? 235 ALA A O   1 
ATOM   5277 C  CB  . ALA B 2 244 ? 176.852 171.255 146.493 1.00 67.41  ? 235 ALA A CB  1 
ATOM   5278 N  N   . PHE B 2 245 ? 178.371 172.552 144.159 1.00 65.80  ? 236 PHE A N   1 
ATOM   5279 C  CA  . PHE B 2 245 ? 179.514 172.769 143.287 1.00 66.11  ? 236 PHE A CA  1 
ATOM   5280 C  C   . PHE B 2 245 ? 179.071 172.607 141.845 1.00 64.89  ? 236 PHE A C   1 
ATOM   5281 O  O   . PHE B 2 245 ? 178.004 172.059 141.562 1.00 68.23  ? 236 PHE A O   1 
ATOM   5282 C  CB  . PHE B 2 245 ? 180.666 171.812 143.604 1.00 69.01  ? 236 PHE A CB  1 
ATOM   5283 C  CG  . PHE B 2 245 ? 180.378 170.377 143.277 1.00 67.23  ? 236 PHE A CG  1 
ATOM   5284 C  CD1 . PHE B 2 245 ? 179.757 169.559 144.196 1.00 66.53  ? 236 PHE A CD1 1 
ATOM   5285 C  CD2 . PHE B 2 245 ? 180.749 169.840 142.059 1.00 68.69  ? 236 PHE A CD2 1 
ATOM   5286 C  CE1 . PHE B 2 245 ? 179.502 168.243 143.903 1.00 69.27  ? 236 PHE A CE1 1 
ATOM   5287 C  CE2 . PHE B 2 245 ? 180.493 168.523 141.763 1.00 69.18  ? 236 PHE A CE2 1 
ATOM   5288 C  CZ  . PHE B 2 245 ? 179.871 167.726 142.686 1.00 70.00  ? 236 PHE A CZ  1 
ATOM   5289 N  N   . GLN B 2 246 ? 179.907 173.093 140.935 1.00 65.49  ? 237 GLN A N   1 
ATOM   5290 C  CA  . GLN B 2 246 ? 179.669 172.951 139.508 1.00 66.89  ? 237 GLN A CA  1 
ATOM   5291 C  C   . GLN B 2 246 ? 180.901 172.344 138.862 1.00 74.20  ? 237 GLN A C   1 
ATOM   5292 O  O   . GLN B 2 246 ? 182.004 172.878 139.003 1.00 82.41  ? 237 GLN A O   1 
ATOM   5293 C  CB  . GLN B 2 246 ? 179.343 174.295 138.861 1.00 66.41  ? 237 GLN A CB  1 
ATOM   5294 C  CG  . GLN B 2 246 ? 178.839 174.171 137.443 1.00 69.91  ? 237 GLN A CG  1 
ATOM   5295 C  CD  . GLN B 2 246 ? 179.212 175.355 136.590 1.00 76.20  ? 237 GLN A CD  1 
ATOM   5296 O  OE1 . GLN B 2 246 ? 178.404 176.254 136.374 1.00 82.12  ? 237 GLN A OE1 1 
ATOM   5297 N  NE2 . GLN B 2 246 ? 180.441 175.364 136.094 1.00 76.08  ? 237 GLN A NE2 1 
ATOM   5298 N  N   . GLU B 2 247 ? 180.713 171.236 138.154 1.00 71.96  ? 238 GLU A N   1 
ATOM   5299 C  CA  . GLU B 2 247 ? 181.802 170.561 137.470 1.00 76.71  ? 238 GLU A CA  1 
ATOM   5300 C  C   . GLU B 2 247 ? 181.437 170.372 136.007 1.00 77.88  ? 238 GLU A C   1 
ATOM   5301 O  O   . GLU B 2 247 ? 180.265 170.215 135.661 1.00 78.70  ? 238 GLU A O   1 
ATOM   5302 C  CB  . GLU B 2 247 ? 182.120 169.212 138.112 1.00 78.30  ? 238 GLU A CB  1 
ATOM   5303 C  CG  . GLU B 2 247 ? 183.143 169.294 139.227 1.00 82.97  ? 238 GLU A CG  1 
ATOM   5304 C  CD  . GLU B 2 247 ? 184.561 169.441 138.711 1.00 89.63  ? 238 GLU A CD  1 
ATOM   5305 O  OE1 . GLU B 2 247 ? 184.768 169.315 137.487 1.00 89.82  ? 238 GLU A OE1 1 
ATOM   5306 O  OE2 . GLU B 2 247 ? 185.472 169.684 139.529 1.00 90.85  ? 238 GLU A OE2 1 
ATOM   5307 N  N   . THR B 2 248 ? 182.454 170.387 135.153 1.00 77.86  ? 239 THR A N   1 
ATOM   5308 C  CA  . THR B 2 248 ? 182.271 170.372 133.708 1.00 80.79  ? 239 THR A CA  1 
ATOM   5309 C  C   . THR B 2 248 ? 182.703 169.025 133.147 1.00 83.55  ? 239 THR A C   1 
ATOM   5310 O  O   . THR B 2 248 ? 183.861 168.626 133.304 1.00 87.11  ? 239 THR A O   1 
ATOM   5311 C  CB  . THR B 2 248 ? 183.063 171.502 133.055 1.00 83.33  ? 239 THR A CB  1 
ATOM   5312 O  OG1 . THR B 2 248 ? 182.670 172.751 133.634 1.00 82.67  ? 239 THR A OG1 1 
ATOM   5313 C  CG2 . THR B 2 248 ? 182.797 171.539 131.564 1.00 83.80  ? 239 THR A CG2 1 
ATOM   5314 N  N   . LEU B 2 249 ? 181.779 168.340 132.488 1.00 81.92  ? 240 LEU A N   1 
ATOM   5315 C  CA  . LEU B 2 249 ? 182.087 167.055 131.876 1.00 82.52  ? 240 LEU A CA  1 
ATOM   5316 C  C   . LEU B 2 249 ? 182.935 167.259 130.627 1.00 87.05  ? 240 LEU A C   1 
ATOM   5317 O  O   . LEU B 2 249 ? 182.615 168.122 129.803 1.00 88.66  ? 240 LEU A O   1 
ATOM   5318 C  CB  . LEU B 2 249 ? 180.804 166.320 131.513 1.00 81.34  ? 240 LEU A CB  1 
ATOM   5319 C  CG  . LEU B 2 249 ? 179.726 166.291 132.587 1.00 78.21  ? 240 LEU A CG  1 
ATOM   5320 C  CD1 . LEU B 2 249 ? 178.384 165.957 131.969 1.00 71.68  ? 240 LEU A CD1 1 
ATOM   5321 C  CD2 . LEU B 2 249 ? 180.089 165.287 133.655 1.00 81.24  ? 240 LEU A CD2 1 
ATOM   5322 N  N   . PRO B 2 250 ? 184.007 166.496 130.444 1.00 90.83  ? 241 PRO A N   1 
ATOM   5323 C  CA  . PRO B 2 250 ? 184.791 166.619 129.214 1.00 94.27  ? 241 PRO A CA  1 
ATOM   5324 C  C   . PRO B 2 250 ? 184.010 166.096 128.022 1.00 98.94  ? 241 PRO A C   1 
ATOM   5325 O  O   . PRO B 2 250 ? 183.162 165.210 128.150 1.00 101.88 ? 241 PRO A O   1 
ATOM   5326 C  CB  . PRO B 2 250 ? 186.023 165.753 129.492 1.00 94.39  ? 241 PRO A CB  1 
ATOM   5327 C  CG  . PRO B 2 250 ? 185.533 164.731 130.453 1.00 92.84  ? 241 PRO A CG  1 
ATOM   5328 C  CD  . PRO B 2 250 ? 184.492 165.403 131.303 1.00 90.22  ? 241 PRO A CD  1 
ATOM   5329 N  N   . THR B 2 251 ? 184.301 166.655 126.851 1.00 102.29 ? 242 THR A N   1 
ATOM   5330 C  CA  . THR B 2 251 ? 183.646 166.198 125.632 1.00 105.66 ? 242 THR A CA  1 
ATOM   5331 C  C   . THR B 2 251 ? 184.069 164.764 125.338 1.00 106.94 ? 242 THR A C   1 
ATOM   5332 O  O   . THR B 2 251 ? 185.261 164.476 125.198 1.00 110.17 ? 242 THR A O   1 
ATOM   5333 C  CB  . THR B 2 251 ? 183.984 167.120 124.461 1.00 106.93 ? 242 THR A CB  1 
ATOM   5334 O  OG1 . THR B 2 251 ? 185.269 166.783 123.924 1.00 104.57 ? 242 THR A OG1 1 
ATOM   5335 C  CG2 . THR B 2 251 ? 184.001 168.567 124.915 1.00 103.16 ? 242 THR A CG2 1 
ATOM   5336 N  N   . LEU B 2 252 ? 183.094 163.859 125.266 1.00 105.55 ? 243 LEU A N   1 
ATOM   5337 C  CA  . LEU B 2 252 ? 183.393 162.440 125.067 1.00 109.90 ? 243 LEU A CA  1 
ATOM   5338 C  C   . LEU B 2 252 ? 182.235 161.823 124.281 1.00 109.61 ? 243 LEU A C   1 
ATOM   5339 O  O   . LEU B 2 252 ? 181.238 161.387 124.859 1.00 108.29 ? 243 LEU A O   1 
ATOM   5340 C  CB  . LEU B 2 252 ? 183.608 161.732 126.395 1.00 108.88 ? 243 LEU A CB  1 
ATOM   5341 C  CG  . LEU B 2 252 ? 185.036 161.737 126.941 1.00 108.17 ? 243 LEU A CG  1 
ATOM   5342 C  CD1 . LEU B 2 252 ? 185.178 160.747 128.076 1.00 107.25 ? 243 LEU A CD1 1 
ATOM   5343 C  CD2 . LEU B 2 252 ? 186.024 161.424 125.839 1.00 111.43 ? 243 LEU A CD2 1 
ATOM   5344 N  N   . GLN B 2 253 ? 182.386 161.784 122.963 1.00 112.23 ? 244 GLN A N   1 
ATOM   5345 C  CA  . GLN B 2 253 ? 181.401 161.128 122.126 1.00 113.13 ? 244 GLN A CA  1 
ATOM   5346 C  C   . GLN B 2 253 ? 181.456 159.618 122.344 1.00 114.85 ? 244 GLN A C   1 
ATOM   5347 O  O   . GLN B 2 253 ? 182.528 159.055 122.574 1.00 115.43 ? 244 GLN A O   1 
ATOM   5348 C  CB  . GLN B 2 253 ? 181.619 161.451 120.644 1.00 114.93 ? 244 GLN A CB  1 
ATOM   5349 C  CG  . GLN B 2 253 ? 182.181 162.846 120.291 1.00 114.84 ? 244 GLN A CG  1 
ATOM   5350 C  CD  . GLN B 2 253 ? 183.690 163.016 120.483 1.00 114.37 ? 244 GLN A CD  1 
ATOM   5351 O  OE1 . GLN B 2 253 ? 184.312 162.393 121.341 1.00 115.28 ? 244 GLN A OE1 1 
ATOM   5352 N  NE2 . GLN B 2 253 ? 184.282 163.880 119.665 1.00 108.49 ? 244 GLN A NE2 1 
ATOM   5353 N  N   . PRO B 2 254 ? 180.309 158.936 122.279 1.00 115.92 ? 245 PRO A N   1 
ATOM   5354 C  CA  . PRO B 2 254 ? 180.299 157.491 122.538 1.00 116.93 ? 245 PRO A CA  1 
ATOM   5355 C  C   . PRO B 2 254 ? 180.920 156.695 121.402 1.00 122.86 ? 245 PRO A C   1 
ATOM   5356 O  O   . PRO B 2 254 ? 181.331 157.268 120.388 1.00 121.21 ? 245 PRO A O   1 
ATOM   5357 C  CB  . PRO B 2 254 ? 178.808 157.175 122.697 1.00 108.62 ? 245 PRO A CB  1 
ATOM   5358 C  CG  . PRO B 2 254 ? 178.129 158.201 121.872 1.00 107.99 ? 245 PRO A CG  1 
ATOM   5359 C  CD  . PRO B 2 254 ? 178.964 159.450 121.969 1.00 110.89 ? 245 PRO A CD  1 
ATOM   5360 N  N   . ASN B 2 255 ? 180.993 155.373 121.570 1.00 124.12 ? 246 ASN A N   1 
ATOM   5361 C  CA  . ASN B 2 255 ? 181.539 154.473 120.553 1.00 123.22 ? 246 ASN A CA  1 
ATOM   5362 C  C   . ASN B 2 255 ? 182.947 154.891 120.136 1.00 121.60 ? 246 ASN A C   1 
ATOM   5363 O  O   . ASN B 2 255 ? 183.286 154.903 118.952 1.00 118.90 ? 246 ASN A O   1 
ATOM   5364 C  CB  . ASN B 2 255 ? 180.613 154.390 119.337 1.00 121.81 ? 246 ASN A CB  1 
ATOM   5365 C  CG  . ASN B 2 255 ? 179.279 153.747 119.664 1.00 119.12 ? 246 ASN A CG  1 
ATOM   5366 O  OD1 . ASN B 2 255 ? 179.079 153.228 120.761 1.00 121.53 ? 246 ASN A OD1 1 
ATOM   5367 N  ND2 . ASN B 2 255 ? 178.355 153.783 118.712 1.00 111.61 ? 246 ASN A ND2 1 
ATOM   5368 N  N   . GLN B 2 256 ? 183.771 155.250 121.118 1.00 122.39 ? 247 GLN A N   1 
ATOM   5369 C  CA  . GLN B 2 256 ? 185.145 155.642 120.850 1.00 126.05 ? 247 GLN A CA  1 
ATOM   5370 C  C   . GLN B 2 256 ? 185.999 155.333 122.070 1.00 130.08 ? 247 GLN A C   1 
ATOM   5371 O  O   . GLN B 2 256 ? 185.495 155.197 123.188 1.00 126.32 ? 247 GLN A O   1 
ATOM   5372 C  CB  . GLN B 2 256 ? 185.239 157.126 120.477 1.00 123.44 ? 247 GLN A CB  1 
ATOM   5373 C  CG  . GLN B 2 256 ? 185.585 158.043 121.633 1.00 124.49 ? 247 GLN A CG  1 
ATOM   5374 C  CD  . GLN B 2 256 ? 186.275 159.309 121.176 1.00 122.37 ? 247 GLN A CD  1 
ATOM   5375 O  OE1 . GLN B 2 256 ? 186.887 159.344 120.110 1.00 119.67 ? 247 GLN A OE1 1 
ATOM   5376 N  NE2 . GLN B 2 256 ? 186.184 160.357 121.984 1.00 120.02 ? 247 GLN A NE2 1 
ATOM   5377 N  N   . ASN B 2 257 ? 187.305 155.220 121.839 1.00 136.01 ? 248 ASN A N   1 
ATOM   5378 C  CA  . ASN B 2 257 ? 188.268 154.927 122.896 1.00 137.76 ? 248 ASN A CA  1 
ATOM   5379 C  C   . ASN B 2 257 ? 188.726 156.245 123.506 1.00 132.64 ? 248 ASN A C   1 
ATOM   5380 O  O   . ASN B 2 257 ? 189.423 157.029 122.854 1.00 132.17 ? 248 ASN A O   1 
ATOM   5381 C  CB  . ASN B 2 257 ? 189.451 154.138 122.340 1.00 146.38 ? 248 ASN A CB  1 
ATOM   5382 C  CG  . ASN B 2 257 ? 189.094 152.698 122.018 1.00 155.33 ? 248 ASN A CG  1 
ATOM   5383 O  OD1 . ASN B 2 257 ? 187.942 152.385 121.714 1.00 154.42 ? 248 ASN A OD1 1 
ATOM   5384 N  ND2 . ASN B 2 257 ? 190.087 151.814 122.080 1.00 162.38 ? 248 ASN A ND2 1 
ATOM   5385 N  N   . MET B 2 258 ? 188.340 156.492 124.754 1.00 127.56 ? 249 MET A N   1 
ATOM   5386 C  CA  . MET B 2 258 ? 188.629 157.765 125.397 1.00 123.26 ? 249 MET A CA  1 
ATOM   5387 C  C   . MET B 2 258 ? 189.942 157.708 126.170 1.00 120.68 ? 249 MET A C   1 
ATOM   5388 O  O   . MET B 2 258 ? 190.334 156.668 126.705 1.00 119.70 ? 249 MET A O   1 
ATOM   5389 C  CB  . MET B 2 258 ? 187.481 158.178 126.318 1.00 117.14 ? 249 MET A CB  1 
ATOM   5390 C  CG  . MET B 2 258 ? 187.545 157.634 127.729 1.00 120.00 ? 249 MET A CG  1 
ATOM   5391 S  SD  . MET B 2 258 ? 185.893 157.285 128.358 1.00 134.45 ? 249 MET A SD  1 
ATOM   5392 C  CE  . MET B 2 258 ? 186.276 156.572 129.949 1.00 116.28 ? 249 MET A CE  1 
ATOM   5393 N  N   . THR B 2 259 ? 190.620 158.850 126.211 1.00 118.49 ? 250 THR A N   1 
ATOM   5394 C  CA  . THR B 2 259 ? 191.945 158.961 126.798 1.00 117.66 ? 250 THR A CA  1 
ATOM   5395 C  C   . THR B 2 259 ? 191.877 158.761 128.312 1.00 116.90 ? 250 THR A C   1 
ATOM   5396 O  O   . THR B 2 259 ? 190.878 159.079 128.962 1.00 117.91 ? 250 THR A O   1 
ATOM   5397 C  CB  . THR B 2 259 ? 192.548 160.326 126.444 1.00 116.04 ? 250 THR A CB  1 
ATOM   5398 O  OG1 . THR B 2 259 ? 192.867 160.352 125.047 1.00 119.40 ? 250 THR A OG1 1 
ATOM   5399 C  CG2 . THR B 2 259 ? 193.816 160.616 127.237 1.00 112.99 ? 250 THR A CG2 1 
ATOM   5400 N  N   . SER B 2 260 ? 192.958 158.206 128.871 1.00 114.37 ? 251 SER A N   1 
ATOM   5401 C  CA  . SER B 2 260 ? 193.017 157.966 130.310 1.00 111.83 ? 251 SER A CA  1 
ATOM   5402 C  C   . SER B 2 260 ? 192.880 159.255 131.111 1.00 111.09 ? 251 SER A C   1 
ATOM   5403 O  O   . SER B 2 260 ? 192.455 159.218 132.270 1.00 109.43 ? 251 SER A O   1 
ATOM   5404 C  CB  . SER B 2 260 ? 194.322 157.265 130.676 1.00 110.83 ? 251 SER A CB  1 
ATOM   5405 O  OG  . SER B 2 260 ? 195.395 158.189 130.704 1.00 109.26 ? 251 SER A OG  1 
ATOM   5406 N  N   . GLU B 2 261 ? 193.250 160.397 130.528 1.00 113.81 ? 252 GLU A N   1 
ATOM   5407 C  CA  . GLU B 2 261 ? 193.021 161.670 131.205 1.00 112.42 ? 252 GLU A CA  1 
ATOM   5408 C  C   . GLU B 2 261 ? 191.533 161.917 131.411 1.00 108.07 ? 252 GLU A C   1 
ATOM   5409 O  O   . GLU B 2 261 ? 191.109 162.361 132.485 1.00 105.15 ? 252 GLU A O   1 
ATOM   5410 C  CB  . GLU B 2 261 ? 193.652 162.812 130.408 1.00 115.18 ? 252 GLU A CB  1 
ATOM   5411 C  CG  . GLU B 2 261 ? 195.152 162.669 130.198 1.00 115.87 ? 252 GLU A CG  1 
ATOM   5412 C  CD  . GLU B 2 261 ? 195.889 163.989 130.316 1.00 117.98 ? 252 GLU A CD  1 
ATOM   5413 O  OE1 . GLU B 2 261 ? 195.790 164.635 131.380 1.00 117.45 ? 252 GLU A OE1 1 
ATOM   5414 O  OE2 . GLU B 2 261 ? 196.572 164.379 129.347 1.00 121.26 ? 252 GLU A OE2 1 
ATOM   5415 N  N   . GLU B 2 262 ? 190.720 161.625 130.394 1.00 108.08 ? 253 GLU A N   1 
ATOM   5416 C  CA  . GLU B 2 262 ? 189.276 161.735 130.553 1.00 103.55 ? 253 GLU A CA  1 
ATOM   5417 C  C   . GLU B 2 262 ? 188.740 160.696 131.527 1.00 102.21 ? 253 GLU A C   1 
ATOM   5418 O  O   . GLU B 2 262 ? 187.771 160.967 132.244 1.00 100.72 ? 253 GLU A O   1 
ATOM   5419 C  CB  . GLU B 2 262 ? 188.589 161.610 129.195 1.00 109.29 ? 253 GLU A CB  1 
ATOM   5420 C  CG  . GLU B 2 262 ? 188.702 162.862 128.340 1.00 112.15 ? 253 GLU A CG  1 
ATOM   5421 C  CD  . GLU B 2 262 ? 189.153 162.566 126.924 1.00 117.38 ? 253 GLU A CD  1 
ATOM   5422 O  OE1 . GLU B 2 262 ? 189.272 161.373 126.574 1.00 119.69 ? 253 GLU A OE1 1 
ATOM   5423 O  OE2 . GLU B 2 262 ? 189.388 163.526 126.160 1.00 115.50 ? 253 GLU A OE2 1 
ATOM   5424 N  N   . ARG B 2 263 ? 189.351 159.510 131.573 1.00 104.52 ? 254 ARG A N   1 
ATOM   5425 C  CA  . ARG B 2 263 ? 188.976 158.524 132.581 1.00 104.69 ? 254 ARG A CA  1 
ATOM   5426 C  C   . ARG B 2 263 ? 189.204 159.066 133.985 1.00 100.63 ? 254 ARG A C   1 
ATOM   5427 O  O   . ARG B 2 263 ? 188.339 158.946 134.860 1.00 100.43 ? 254 ARG A O   1 
ATOM   5428 C  CB  . ARG B 2 263 ? 189.767 157.233 132.372 1.00 110.70 ? 254 ARG A CB  1 
ATOM   5429 C  CG  . ARG B 2 263 ? 189.684 156.258 133.538 1.00 114.82 ? 254 ARG A CG  1 
ATOM   5430 C  CD  . ARG B 2 263 ? 188.298 155.644 133.687 1.00 116.42 ? 254 ARG A CD  1 
ATOM   5431 N  NE  . ARG B 2 263 ? 187.773 155.125 132.430 1.00 119.35 ? 254 ARG A NE  1 
ATOM   5432 C  CZ  . ARG B 2 263 ? 188.244 154.058 131.800 1.00 121.37 ? 254 ARG A CZ  1 
ATOM   5433 N  NH1 . ARG B 2 263 ? 189.257 153.359 132.284 1.00 124.54 ? 254 ARG A NH1 1 
ATOM   5434 N  NH2 . ARG B 2 263 ? 187.681 153.679 130.657 1.00 119.27 ? 254 ARG A NH2 1 
ATOM   5435 N  N   . GLN B 2 264 ? 190.366 159.677 134.215 1.00 99.15  ? 255 GLN A N   1 
ATOM   5436 C  CA  . GLN B 2 264 ? 190.650 160.261 135.521 1.00 99.29  ? 255 GLN A CA  1 
ATOM   5437 C  C   . GLN B 2 264 ? 189.695 161.404 135.831 1.00 98.64  ? 255 GLN A C   1 
ATOM   5438 O  O   . GLN B 2 264 ? 189.239 161.549 136.970 1.00 98.55  ? 255 GLN A O   1 
ATOM   5439 C  CB  . GLN B 2 264 ? 192.095 160.747 135.577 1.00 102.68 ? 255 GLN A CB  1 
ATOM   5440 C  CG  . GLN B 2 264 ? 192.627 160.919 136.984 1.00 102.16 ? 255 GLN A CG  1 
ATOM   5441 C  CD  . GLN B 2 264 ? 192.476 159.665 137.814 1.00 104.95 ? 255 GLN A CD  1 
ATOM   5442 O  OE1 . GLN B 2 264 ? 192.985 158.606 137.452 1.00 111.05 ? 255 GLN A OE1 1 
ATOM   5443 N  NE2 . GLN B 2 264 ? 191.773 159.776 138.934 1.00 99.73  ? 255 GLN A NE2 1 
ATOM   5444 N  N   . ARG B 2 265 ? 189.387 162.234 134.834 1.00 97.47  ? 256 ARG A N   1 
ATOM   5445 C  CA  . ARG B 2 265 ? 188.464 163.342 135.058 1.00 94.06  ? 256 ARG A CA  1 
ATOM   5446 C  C   . ARG B 2 265 ? 187.076 162.842 135.440 1.00 92.61  ? 256 ARG A C   1 
ATOM   5447 O  O   . ARG B 2 265 ? 186.451 163.368 136.369 1.00 90.44  ? 256 ARG A O   1 
ATOM   5448 C  CB  . ARG B 2 265 ? 188.393 164.221 133.813 1.00 94.76  ? 256 ARG A CB  1 
ATOM   5449 C  CG  . ARG B 2 265 ? 187.624 165.508 134.020 1.00 96.69  ? 256 ARG A CG  1 
ATOM   5450 C  CD  . ARG B 2 265 ? 188.269 166.654 133.267 1.00 97.92  ? 256 ARG A CD  1 
ATOM   5451 N  NE  . ARG B 2 265 ? 187.539 167.902 133.445 1.00 97.91  ? 256 ARG A NE  1 
ATOM   5452 C  CZ  . ARG B 2 265 ? 187.519 168.605 134.568 1.00 103.15 ? 256 ARG A CZ  1 
ATOM   5453 N  NH1 . ARG B 2 265 ? 188.179 168.211 135.644 1.00 100.06 ? 256 ARG A NH1 1 
ATOM   5454 N  NH2 . ARG B 2 265 ? 186.820 169.735 134.613 1.00 105.04 ? 256 ARG A NH2 1 
ATOM   5455 N  N   . LEU B 2 266 ? 186.576 161.826 134.735 1.00 94.54  ? 257 LEU A N   1 
ATOM   5456 C  CA  . LEU B 2 266 ? 185.268 161.273 135.061 1.00 91.32  ? 257 LEU A CA  1 
ATOM   5457 C  C   . LEU B 2 266 ? 185.273 160.614 136.434 1.00 92.43  ? 257 LEU A C   1 
ATOM   5458 O  O   . LEU B 2 266 ? 184.303 160.740 137.193 1.00 93.63  ? 257 LEU A O   1 
ATOM   5459 C  CB  . LEU B 2 266 ? 184.843 160.277 133.988 1.00 90.30  ? 257 LEU A CB  1 
ATOM   5460 C  CG  . LEU B 2 266 ? 184.413 160.915 132.673 1.00 89.75  ? 257 LEU A CG  1 
ATOM   5461 C  CD1 . LEU B 2 266 ? 183.870 159.864 131.729 1.00 94.15  ? 257 LEU A CD1 1 
ATOM   5462 C  CD2 . LEU B 2 266 ? 183.381 161.995 132.928 1.00 83.27  ? 257 LEU A CD2 1 
ATOM   5463 N  N   . VAL B 2 267 ? 186.354 159.908 136.771 1.00 90.23  ? 258 VAL A N   1 
ATOM   5464 C  CA  . VAL B 2 267 ? 186.463 159.306 138.095 1.00 86.77  ? 258 VAL A CA  1 
ATOM   5465 C  C   . VAL B 2 267 ? 186.406 160.385 139.165 1.00 87.94  ? 258 VAL A C   1 
ATOM   5466 O  O   . VAL B 2 267 ? 185.702 160.250 140.172 1.00 89.27  ? 258 VAL A O   1 
ATOM   5467 C  CB  . VAL B 2 267 ? 187.752 158.474 138.203 1.00 89.09  ? 258 VAL A CB  1 
ATOM   5468 C  CG1 . VAL B 2 267 ? 188.092 158.202 139.654 1.00 88.93  ? 258 VAL A CG1 1 
ATOM   5469 C  CG2 . VAL B 2 267 ? 187.602 157.174 137.449 1.00 92.63  ? 258 VAL A CG2 1 
ATOM   5470 N  N   . THR B 2 268 ? 187.138 161.479 138.956 1.00 89.44  ? 259 THR A N   1 
ATOM   5471 C  CA  . THR B 2 268 ? 187.136 162.571 139.922 1.00 87.53  ? 259 THR A CA  1 
ATOM   5472 C  C   . THR B 2 268 ? 185.751 163.185 140.058 1.00 85.37  ? 259 THR A C   1 
ATOM   5473 O  O   . THR B 2 268 ? 185.299 163.476 141.171 1.00 86.44  ? 259 THR A O   1 
ATOM   5474 C  CB  . THR B 2 268 ? 188.151 163.635 139.511 1.00 86.59  ? 259 THR A CB  1 
ATOM   5475 O  OG1 . THR B 2 268 ? 189.469 163.075 139.534 1.00 92.21  ? 259 THR A OG1 1 
ATOM   5476 C  CG2 . THR B 2 268 ? 188.095 164.818 140.457 1.00 83.20  ? 259 THR A CG2 1 
ATOM   5477 N  N   . ILE B 2 269 ? 185.058 163.387 138.936 1.00 84.41  ? 260 ILE A N   1 
ATOM   5478 C  CA  . ILE B 2 269 ? 183.736 164.004 138.991 1.00 83.78  ? 260 ILE A CA  1 
ATOM   5479 C  C   . ILE B 2 269 ? 182.760 163.114 139.750 1.00 84.71  ? 260 ILE A C   1 
ATOM   5480 O  O   . ILE B 2 269 ? 181.995 163.591 140.597 1.00 85.41  ? 260 ILE A O   1 
ATOM   5481 C  CB  . ILE B 2 269 ? 183.234 164.325 137.573 1.00 81.85  ? 260 ILE A CB  1 
ATOM   5482 C  CG1 . ILE B 2 269 ? 184.003 165.513 137.002 1.00 81.26  ? 260 ILE A CG1 1 
ATOM   5483 C  CG2 . ILE B 2 269 ? 181.757 164.633 137.593 1.00 77.02  ? 260 ILE A CG2 1 
ATOM   5484 C  CD1 . ILE B 2 269 ? 183.601 165.877 135.602 1.00 83.04  ? 260 ILE A CD1 1 
ATOM   5485 N  N   . VAL B 2 270 ? 182.773 161.809 139.473 1.00 83.42  ? 261 VAL A N   1 
ATOM   5486 C  CA  . VAL B 2 270 ? 181.853 160.912 140.168 1.00 78.65  ? 261 VAL A CA  1 
ATOM   5487 C  C   . VAL B 2 270 ? 182.216 160.808 141.645 1.00 82.06  ? 261 VAL A C   1 
ATOM   5488 O  O   . VAL B 2 270 ? 181.335 160.708 142.507 1.00 82.15  ? 261 VAL A O   1 
ATOM   5489 C  CB  . VAL B 2 270 ? 181.828 159.534 139.491 1.00 77.07  ? 261 VAL A CB  1 
ATOM   5490 C  CG1 . VAL B 2 270 ? 180.907 158.599 140.242 1.00 76.89  ? 261 VAL A CG1 1 
ATOM   5491 C  CG2 . VAL B 2 270 ? 181.378 159.671 138.058 1.00 78.67  ? 261 VAL A CG2 1 
ATOM   5492 N  N   . ASP B 2 271 ? 183.512 160.825 141.965 1.00 84.46  ? 262 ASP A N   1 
ATOM   5493 C  CA  . ASP B 2 271 ? 183.923 160.789 143.364 1.00 83.58  ? 262 ASP A CA  1 
ATOM   5494 C  C   . ASP B 2 271 ? 183.442 162.027 144.105 1.00 81.48  ? 262 ASP A C   1 
ATOM   5495 O  O   . ASP B 2 271 ? 182.982 161.937 145.249 1.00 82.03  ? 262 ASP A O   1 
ATOM   5496 C  CB  . ASP B 2 271 ? 185.442 160.660 143.463 1.00 85.86  ? 262 ASP A CB  1 
ATOM   5497 C  CG  . ASP B 2 271 ? 185.909 159.219 143.417 1.00 91.26  ? 262 ASP A CG  1 
ATOM   5498 O  OD1 . ASP B 2 271 ? 185.072 158.316 143.622 1.00 93.48  ? 262 ASP A OD1 1 
ATOM   5499 O  OD2 . ASP B 2 271 ? 187.113 158.986 143.183 1.00 91.76  ? 262 ASP A OD2 1 
ATOM   5500 N  N   . LYS B 2 272 ? 183.541 163.194 143.468 1.00 78.51  ? 263 LYS A N   1 
ATOM   5501 C  CA  . LYS B 2 272 ? 183.022 164.411 144.080 1.00 75.13  ? 263 LYS A CA  1 
ATOM   5502 C  C   . LYS B 2 272 ? 181.510 164.345 144.234 1.00 77.74  ? 263 LYS A C   1 
ATOM   5503 O  O   . LYS B 2 272 ? 180.964 164.805 145.243 1.00 80.83  ? 263 LYS A O   1 
ATOM   5504 C  CB  . LYS B 2 272 ? 183.428 165.630 143.258 1.00 69.81  ? 263 LYS A CB  1 
ATOM   5505 C  CG  . LYS B 2 272 ? 184.814 166.140 143.580 1.00 70.30  ? 263 LYS A CG  1 
ATOM   5506 C  CD  . LYS B 2 272 ? 185.038 167.518 143.005 1.00 70.20  ? 263 LYS A CD  1 
ATOM   5507 C  CE  . LYS B 2 272 ? 185.908 167.441 141.770 1.00 76.02  ? 263 LYS A CE  1 
ATOM   5508 N  NZ  . LYS B 2 272 ? 187.122 168.291 141.880 1.00 78.77  ? 263 LYS A NZ  1 
ATOM   5509 N  N   . LEU B 2 273 ? 180.816 163.776 143.246 1.00 77.36  ? 264 LEU A N   1 
ATOM   5510 C  CA  . LEU B 2 273 ? 179.371 163.608 143.364 1.00 76.88  ? 264 LEU A CA  1 
ATOM   5511 C  C   . LEU B 2 273 ? 179.018 162.740 144.562 1.00 77.33  ? 264 LEU A C   1 
ATOM   5512 O  O   . LEU B 2 273 ? 178.082 163.046 145.307 1.00 77.67  ? 264 LEU A O   1 
ATOM   5513 C  CB  . LEU B 2 273 ? 178.803 162.989 142.089 1.00 76.69  ? 264 LEU A CB  1 
ATOM   5514 C  CG  . LEU B 2 273 ? 178.159 163.896 141.045 1.00 80.28  ? 264 LEU A CG  1 
ATOM   5515 C  CD1 . LEU B 2 273 ? 179.093 165.020 140.654 1.00 80.38  ? 264 LEU A CD1 1 
ATOM   5516 C  CD2 . LEU B 2 273 ? 177.757 163.085 139.828 1.00 80.65  ? 264 LEU A CD2 1 
ATOM   5517 N  N   . GLN B 2 274 ? 179.753 161.648 144.757 1.00 78.63  ? 265 GLN A N   1 
ATOM   5518 C  CA  . GLN B 2 274 ? 179.452 160.743 145.860 1.00 76.64  ? 265 GLN A CA  1 
ATOM   5519 C  C   . GLN B 2 274 ? 179.785 161.370 147.206 1.00 76.05  ? 265 GLN A C   1 
ATOM   5520 O  O   . GLN B 2 274 ? 179.029 161.215 148.170 1.00 78.09  ? 265 GLN A O   1 
ATOM   5521 C  CB  . GLN B 2 274 ? 180.208 159.430 145.685 1.00 78.54  ? 265 GLN A CB  1 
ATOM   5522 C  CG  . GLN B 2 274 ? 179.993 158.458 146.821 1.00 80.19  ? 265 GLN A CG  1 
ATOM   5523 C  CD  . GLN B 2 274 ? 179.266 157.213 146.382 1.00 87.14  ? 265 GLN A CD  1 
ATOM   5524 O  OE1 . GLN B 2 274 ? 179.632 156.587 145.389 1.00 93.42  ? 265 GLN A OE1 1 
ATOM   5525 N  NE2 . GLN B 2 274 ? 178.229 156.841 147.121 1.00 84.44  ? 265 GLN A NE2 1 
ATOM   5526 N  N   . GLN B 2 275 ? 180.914 162.074 147.295 1.00 76.00  ? 266 GLN A N   1 
ATOM   5527 C  CA  . GLN B 2 275 ? 181.321 162.656 148.570 1.00 75.88  ? 266 GLN A CA  1 
ATOM   5528 C  C   . GLN B 2 275 ? 180.339 163.726 149.030 1.00 78.56  ? 266 GLN A C   1 
ATOM   5529 O  O   . GLN B 2 275 ? 180.046 163.834 150.225 1.00 79.69  ? 266 GLN A O   1 
ATOM   5530 C  CB  . GLN B 2 275 ? 182.733 163.229 148.454 1.00 80.57  ? 266 GLN A CB  1 
ATOM   5531 C  CG  . GLN B 2 275 ? 183.003 164.427 149.350 1.00 87.59  ? 266 GLN A CG  1 
ATOM   5532 C  CD  . GLN B 2 275 ? 184.164 165.272 148.866 1.00 89.46  ? 266 GLN A CD  1 
ATOM   5533 O  OE1 . GLN B 2 275 ? 183.973 166.270 148.173 1.00 88.57  ? 266 GLN A OE1 1 
ATOM   5534 N  NE2 . GLN B 2 275 ? 185.376 164.877 149.231 1.00 89.45  ? 266 GLN A NE2 1 
ATOM   5535 N  N   . SER B 2 276 ? 179.817 164.518 148.099 1.00 79.50  ? 267 SER A N   1 
ATOM   5536 C  CA  . SER B 2 276 ? 178.923 165.611 148.449 1.00 79.32  ? 267 SER A CA  1 
ATOM   5537 C  C   . SER B 2 276 ? 177.621 165.090 149.043 1.00 78.21  ? 267 SER A C   1 
ATOM   5538 O  O   . SER B 2 276 ? 177.144 164.005 148.704 1.00 76.85  ? 267 SER A O   1 
ATOM   5539 C  CB  . SER B 2 276 ? 178.621 166.464 147.221 1.00 80.56  ? 267 SER A CB  1 
ATOM   5540 O  OG  . SER B 2 276 ? 178.205 167.762 147.601 1.00 84.70  ? 267 SER A OG  1 
ATOM   5541 N  N   . THR B 2 277 ? 177.046 165.881 149.946 1.00 77.61  ? 268 THR A N   1 
ATOM   5542 C  CA  . THR B 2 277 ? 175.793 165.532 150.599 1.00 80.59  ? 268 THR A CA  1 
ATOM   5543 C  C   . THR B 2 277 ? 174.567 165.902 149.775 1.00 82.07  ? 268 THR A C   1 
ATOM   5544 O  O   . THR B 2 277 ? 173.456 165.495 150.131 1.00 81.56  ? 268 THR A O   1 
ATOM   5545 C  CB  . THR B 2 277 ? 175.712 166.203 151.973 1.00 77.65  ? 268 THR A CB  1 
ATOM   5546 O  OG1 . THR B 2 277 ? 174.434 165.944 152.567 1.00 81.63  ? 268 THR A OG1 1 
ATOM   5547 C  CG2 . THR B 2 277 ? 175.910 167.698 151.843 1.00 76.43  ? 268 THR A CG2 1 
ATOM   5548 N  N   . ALA B 2 278 ? 174.735 166.655 148.692 1.00 78.89  ? 269 ALA A N   1 
ATOM   5549 C  CA  . ALA B 2 278 ? 173.614 166.970 147.818 1.00 74.05  ? 269 ALA A CA  1 
ATOM   5550 C  C   . ALA B 2 278 ? 173.167 165.734 147.050 1.00 72.01  ? 269 ALA A C   1 
ATOM   5551 O  O   . ALA B 2 278 ? 173.987 164.929 146.604 1.00 73.03  ? 269 ALA A O   1 
ATOM   5552 C  CB  . ALA B 2 278 ? 173.995 168.076 146.840 1.00 71.26  ? 269 ALA A CB  1 
ATOM   5553 N  N   . ARG B 2 279 ? 171.855 165.592 146.887 1.00 67.33  ? 270 ARG A N   1 
ATOM   5554 C  CA  . ARG B 2 279 ? 171.284 164.447 146.191 1.00 64.60  ? 270 ARG A CA  1 
ATOM   5555 C  C   . ARG B 2 279 ? 170.336 164.886 145.083 1.00 65.37  ? 270 ARG A C   1 
ATOM   5556 O  O   . ARG B 2 279 ? 169.368 164.187 144.776 1.00 68.18  ? 270 ARG A O   1 
ATOM   5557 C  CB  . ARG B 2 279 ? 170.572 163.518 147.169 1.00 63.50  ? 270 ARG A CB  1 
ATOM   5558 C  CG  . ARG B 2 279 ? 171.518 162.708 148.034 1.00 70.01  ? 270 ARG A CG  1 
ATOM   5559 C  CD  . ARG B 2 279 ? 172.566 162.009 147.186 1.00 72.55  ? 270 ARG A CD  1 
ATOM   5560 N  NE  . ARG B 2 279 ? 173.634 161.438 147.994 1.00 73.17  ? 270 ARG A NE  1 
ATOM   5561 C  CZ  . ARG B 2 279 ? 174.920 161.513 147.689 1.00 73.55  ? 270 ARG A CZ  1 
ATOM   5562 N  NH1 . ARG B 2 279 ? 175.333 162.115 146.588 1.00 76.99  ? 270 ARG A NH1 1 
ATOM   5563 N  NH2 . ARG B 2 279 ? 175.814 160.970 148.509 1.00 76.19  ? 270 ARG A NH2 1 
ATOM   5564 N  N   . VAL B 2 280 ? 170.589 166.048 144.486 1.00 61.35  ? 271 VAL A N   1 
ATOM   5565 C  CA  . VAL B 2 280 ? 169.841 166.505 143.322 1.00 53.80  ? 271 VAL A CA  1 
ATOM   5566 C  C   . VAL B 2 280 ? 170.830 167.037 142.300 1.00 52.60  ? 271 VAL A C   1 
ATOM   5567 O  O   . VAL B 2 280 ? 171.359 168.140 142.455 1.00 59.99  ? 271 VAL A O   1 
ATOM   5568 C  CB  . VAL B 2 280 ? 168.816 167.585 143.697 1.00 53.61  ? 271 VAL A CB  1 
ATOM   5569 C  CG1 . VAL B 2 280 ? 168.202 168.166 142.447 1.00 57.71  ? 271 VAL A CG1 1 
ATOM   5570 C  CG2 . VAL B 2 280 ? 167.748 167.012 144.594 1.00 59.04  ? 271 VAL A CG2 1 
ATOM   5571 N  N   . VAL B 2 281 ? 171.088 166.268 141.250 1.00 46.83  ? 272 VAL A N   1 
ATOM   5572 C  CA  . VAL B 2 281 ? 172.100 166.611 140.261 1.00 49.30  ? 272 VAL A CA  1 
ATOM   5573 C  C   . VAL B 2 281 ? 171.397 167.083 138.999 1.00 53.45  ? 272 VAL A C   1 
ATOM   5574 O  O   . VAL B 2 281 ? 170.593 166.348 138.417 1.00 59.77  ? 272 VAL A O   1 
ATOM   5575 C  CB  . VAL B 2 281 ? 173.022 165.422 139.963 1.00 50.96  ? 272 VAL A CB  1 
ATOM   5576 C  CG1 . VAL B 2 281 ? 174.239 165.884 139.203 1.00 54.24  ? 272 VAL A CG1 1 
ATOM   5577 C  CG2 . VAL B 2 281 ? 173.426 164.744 141.253 1.00 56.59  ? 272 VAL A CG2 1 
ATOM   5578 N  N   . VAL B 2 282 ? 171.707 168.303 138.573 1.00 51.16  ? 273 VAL A N   1 
ATOM   5579 C  CA  . VAL B 2 282 ? 171.146 168.891 137.364 1.00 49.09  ? 273 VAL A CA  1 
ATOM   5580 C  C   . VAL B 2 282 ? 172.207 168.824 136.279 1.00 56.07  ? 273 VAL A C   1 
ATOM   5581 O  O   . VAL B 2 282 ? 173.303 169.369 136.444 1.00 64.20  ? 273 VAL A O   1 
ATOM   5582 C  CB  . VAL B 2 282 ? 170.700 170.340 137.605 1.00 47.65  ? 273 VAL A CB  1 
ATOM   5583 C  CG1 . VAL B 2 282 ? 169.983 170.873 136.391 1.00 55.69  ? 273 VAL A CG1 1 
ATOM   5584 C  CG2 . VAL B 2 282 ? 169.813 170.418 138.823 1.00 48.05  ? 273 VAL A CG2 1 
ATOM   5585 N  N   . VAL B 2 283 ? 171.890 168.171 135.166 1.00 52.15  ? 274 VAL A N   1 
ATOM   5586 C  CA  . VAL B 2 283 ? 172.853 167.932 134.099 1.00 54.51  ? 274 VAL A CA  1 
ATOM   5587 C  C   . VAL B 2 283 ? 172.437 168.744 132.882 1.00 60.73  ? 274 VAL A C   1 
ATOM   5588 O  O   . VAL B 2 283 ? 171.325 168.581 132.367 1.00 63.27  ? 274 VAL A O   1 
ATOM   5589 C  CB  . VAL B 2 283 ? 172.960 166.440 133.760 1.00 54.83  ? 274 VAL A CB  1 
ATOM   5590 C  CG1 . VAL B 2 283 ? 174.286 166.151 133.095 1.00 62.32  ? 274 VAL A CG1 1 
ATOM   5591 C  CG2 . VAL B 2 283 ? 172.809 165.609 135.011 1.00 57.33  ? 274 VAL A CG2 1 
ATOM   5592 N  N   . PHE B 2 284 ? 173.335 169.611 132.420 1.00 67.28  ? 275 PHE A N   1 
ATOM   5593 C  CA  . PHE B 2 284 ? 173.135 170.460 131.247 1.00 71.08  ? 275 PHE A CA  1 
ATOM   5594 C  C   . PHE B 2 284 ? 174.168 170.045 130.209 1.00 72.18  ? 275 PHE A C   1 
ATOM   5595 O  O   . PHE B 2 284 ? 175.263 170.607 130.158 1.00 75.72  ? 275 PHE A O   1 
ATOM   5596 C  CB  . PHE B 2 284 ? 173.287 171.931 131.594 1.00 74.75  ? 275 PHE A CB  1 
ATOM   5597 C  CG  . PHE B 2 284 ? 172.119 172.512 132.319 1.00 76.20  ? 275 PHE A CG  1 
ATOM   5598 C  CD1 . PHE B 2 284 ? 170.893 172.624 131.703 1.00 75.95  ? 275 PHE A CD1 1 
ATOM   5599 C  CD2 . PHE B 2 284 ? 172.253 172.968 133.613 1.00 74.03  ? 275 PHE A CD2 1 
ATOM   5600 C  CE1 . PHE B 2 284 ? 169.821 173.167 132.369 1.00 76.33  ? 275 PHE A CE1 1 
ATOM   5601 C  CE2 . PHE B 2 284 ? 171.185 173.511 134.280 1.00 71.61  ? 275 PHE A CE2 1 
ATOM   5602 C  CZ  . PHE B 2 284 ? 169.967 173.609 133.659 1.00 73.39  ? 275 PHE A CZ  1 
ATOM   5603 N  N   . SER B 2 285 ? 173.826 169.070 129.375 1.00 69.68  ? 276 SER A N   1 
ATOM   5604 C  CA  . SER B 2 285 ? 174.777 168.591 128.387 1.00 72.43  ? 276 SER A CA  1 
ATOM   5605 C  C   . SER B 2 285 ? 174.020 168.000 127.213 1.00 78.49  ? 276 SER A C   1 
ATOM   5606 O  O   . SER B 2 285 ? 172.886 167.538 127.382 1.00 79.38  ? 276 SER A O   1 
ATOM   5607 C  CB  . SER B 2 285 ? 175.720 167.544 128.989 1.00 76.31  ? 276 SER A CB  1 
ATOM   5608 O  OG  . SER B 2 285 ? 176.467 166.893 127.981 1.00 83.64  ? 276 SER A OG  1 
ATOM   5609 N  N   . PRO B 2 286 ? 174.608 168.005 126.019 1.00 81.56  ? 277 PRO A N   1 
ATOM   5610 C  CA  . PRO B 2 286 ? 173.968 167.339 124.883 1.00 83.05  ? 277 PRO A CA  1 
ATOM   5611 C  C   . PRO B 2 286 ? 173.828 165.847 125.130 1.00 86.41  ? 277 PRO A C   1 
ATOM   5612 O  O   . PRO B 2 286 ? 174.584 165.236 125.887 1.00 87.19  ? 277 PRO A O   1 
ATOM   5613 C  CB  . PRO B 2 286 ? 174.921 167.625 123.719 1.00 81.76  ? 277 PRO A CB  1 
ATOM   5614 C  CG  . PRO B 2 286 ? 175.631 168.863 124.118 1.00 82.26  ? 277 PRO A CG  1 
ATOM   5615 C  CD  . PRO B 2 286 ? 175.787 168.781 125.603 1.00 83.02  ? 277 PRO A CD  1 
ATOM   5616 N  N   . ASP B 2 287 ? 172.835 165.261 124.467 1.00 87.74  ? 278 ASP A N   1 
ATOM   5617 C  CA  . ASP B 2 287 ? 172.451 163.878 124.711 1.00 86.69  ? 278 ASP A CA  1 
ATOM   5618 C  C   . ASP B 2 287 ? 173.510 162.868 124.291 1.00 90.64  ? 278 ASP A C   1 
ATOM   5619 O  O   . ASP B 2 287 ? 173.375 161.687 124.626 1.00 88.84  ? 278 ASP A O   1 
ATOM   5620 C  CB  . ASP B 2 287 ? 171.129 163.579 124.000 1.00 91.17  ? 278 ASP A CB  1 
ATOM   5621 C  CG  . ASP B 2 287 ? 171.156 163.938 122.519 1.00 96.82  ? 278 ASP A CG  1 
ATOM   5622 O  OD1 . ASP B 2 287 ? 172.229 164.295 121.990 1.00 95.87  ? 278 ASP A OD1 1 
ATOM   5623 O  OD2 . ASP B 2 287 ? 170.087 163.865 121.877 1.00 94.44  ? 278 ASP A OD2 1 
ATOM   5624 N  N   . LEU B 2 288 ? 174.544 163.288 123.567 1.00 94.15  ? 279 LEU A N   1 
ATOM   5625 C  CA  . LEU B 2 288 ? 175.552 162.356 123.077 1.00 92.51  ? 279 LEU A CA  1 
ATOM   5626 C  C   . LEU B 2 288 ? 176.684 162.125 124.070 1.00 92.17  ? 279 LEU A C   1 
ATOM   5627 O  O   . LEU B 2 288 ? 177.217 161.014 124.148 1.00 95.48  ? 279 LEU A O   1 
ATOM   5628 C  CB  . LEU B 2 288 ? 176.131 162.860 121.753 1.00 94.73  ? 279 LEU A CB  1 
ATOM   5629 C  CG  . LEU B 2 288 ? 175.108 163.249 120.689 1.00 96.27  ? 279 LEU A CG  1 
ATOM   5630 C  CD1 . LEU B 2 288 ? 175.764 164.059 119.587 1.00 96.89  ? 279 LEU A CD1 1 
ATOM   5631 C  CD2 . LEU B 2 288 ? 174.446 162.011 120.129 1.00 94.07  ? 279 LEU A CD2 1 
ATOM   5632 N  N   . THR B 2 289 ? 177.067 163.143 124.834 1.00 90.54  ? 280 THR A N   1 
ATOM   5633 C  CA  . THR B 2 289 ? 178.253 163.068 125.676 1.00 91.72  ? 280 THR A CA  1 
ATOM   5634 C  C   . THR B 2 289 ? 177.970 162.507 127.063 1.00 88.50  ? 280 THR A C   1 
ATOM   5635 O  O   . THR B 2 289 ? 178.866 162.512 127.912 1.00 84.83  ? 280 THR A O   1 
ATOM   5636 C  CB  . THR B 2 289 ? 178.898 164.449 125.808 1.00 91.48  ? 280 THR A CB  1 
ATOM   5637 O  OG1 . THR B 2 289 ? 178.351 165.127 126.943 1.00 85.35  ? 280 THR A OG1 1 
ATOM   5638 C  CG2 . THR B 2 289 ? 178.645 165.275 124.558 1.00 90.30  ? 280 THR A CG2 1 
ATOM   5639 N  N   . LEU B 2 290 ? 176.752 162.037 127.319 1.00 88.95  ? 281 LEU A N   1 
ATOM   5640 C  CA  . LEU B 2 290 ? 176.405 161.506 128.629 1.00 85.08  ? 281 LEU A CA  1 
ATOM   5641 C  C   . LEU B 2 290 ? 176.602 160.001 128.749 1.00 85.46  ? 281 LEU A C   1 
ATOM   5642 O  O   . LEU B 2 290 ? 176.513 159.474 129.861 1.00 88.12  ? 281 LEU A O   1 
ATOM   5643 C  CB  . LEU B 2 290 ? 174.953 161.851 128.971 1.00 77.83  ? 281 LEU A CB  1 
ATOM   5644 C  CG  . LEU B 2 290 ? 174.664 163.332 129.203 1.00 72.40  ? 281 LEU A CG  1 
ATOM   5645 C  CD1 . LEU B 2 290 ? 173.189 163.549 129.442 1.00 69.20  ? 281 LEU A CD1 1 
ATOM   5646 C  CD2 . LEU B 2 290 ? 175.472 163.852 130.371 1.00 71.70  ? 281 LEU A CD2 1 
ATOM   5647 N  N   . TYR B 2 291 ? 176.873 159.298 127.649 1.00 85.68  ? 282 TYR A N   1 
ATOM   5648 C  CA  . TYR B 2 291 ? 176.982 157.843 127.720 1.00 90.35  ? 282 TYR A CA  1 
ATOM   5649 C  C   . TYR B 2 291 ? 178.168 157.417 128.573 1.00 91.95  ? 282 TYR A C   1 
ATOM   5650 O  O   . TYR B 2 291 ? 178.032 156.573 129.466 1.00 93.56  ? 282 TYR A O   1 
ATOM   5651 C  CB  . TYR B 2 291 ? 177.094 157.257 126.316 1.00 92.24  ? 282 TYR A CB  1 
ATOM   5652 C  CG  . TYR B 2 291 ? 175.783 157.225 125.578 1.00 101.09 ? 282 TYR A CG  1 
ATOM   5653 C  CD1 . TYR B 2 291 ? 175.289 158.363 124.960 1.00 101.87 ? 282 TYR A CD1 1 
ATOM   5654 C  CD2 . TYR B 2 291 ? 175.036 156.059 125.501 1.00 104.07 ? 282 TYR A CD2 1 
ATOM   5655 C  CE1 . TYR B 2 291 ? 174.090 158.343 124.285 1.00 101.57 ? 282 TYR A CE1 1 
ATOM   5656 C  CE2 . TYR B 2 291 ? 173.834 156.030 124.826 1.00 104.32 ? 282 TYR A CE2 1 
ATOM   5657 C  CZ  . TYR B 2 291 ? 173.368 157.176 124.220 1.00 102.20 ? 282 TYR A CZ  1 
ATOM   5658 O  OH  . TYR B 2 291 ? 172.174 157.161 123.548 1.00 93.79  ? 282 TYR A OH  1 
ATOM   5659 N  N   . HIS B 2 292 ? 179.343 157.991 128.311 1.00 89.78  ? 283 HIS A N   1 
ATOM   5660 C  CA  . HIS B 2 292 ? 180.521 157.642 129.097 1.00 90.54  ? 283 HIS A CA  1 
ATOM   5661 C  C   . HIS B 2 292 ? 180.347 158.040 130.555 1.00 88.86  ? 283 HIS A C   1 
ATOM   5662 O  O   . HIS B 2 292 ? 180.740 157.295 131.462 1.00 88.47  ? 283 HIS A O   1 
ATOM   5663 C  CB  . HIS B 2 292 ? 181.762 158.301 128.501 1.00 93.75  ? 283 HIS A CB  1 
ATOM   5664 C  CG  . HIS B 2 292 ? 182.309 157.586 127.307 1.00 102.22 ? 283 HIS A CG  1 
ATOM   5665 N  ND1 . HIS B 2 292 ? 182.638 158.234 126.137 1.00 108.49 ? 283 HIS A ND1 1 
ATOM   5666 C  CD2 . HIS B 2 292 ? 182.583 156.277 127.102 1.00 101.93 ? 283 HIS A CD2 1 
ATOM   5667 C  CE1 . HIS B 2 292 ? 183.093 157.355 125.263 1.00 109.68 ? 283 HIS A CE1 1 
ATOM   5668 N  NE2 . HIS B 2 292 ? 183.069 156.159 125.823 1.00 106.24 ? 283 HIS A NE2 1 
ATOM   5669 N  N   . PHE B 2 293 ? 179.757 159.210 130.802 1.00 85.34  ? 284 PHE A N   1 
ATOM   5670 C  CA  . PHE B 2 293 ? 179.557 159.655 132.175 1.00 79.62  ? 284 PHE A CA  1 
ATOM   5671 C  C   . PHE B 2 293 ? 178.635 158.710 132.932 1.00 79.73  ? 284 PHE A C   1 
ATOM   5672 O  O   . PHE B 2 293 ? 178.916 158.344 134.080 1.00 83.83  ? 284 PHE A O   1 
ATOM   5673 C  CB  . PHE B 2 293 ? 178.994 161.072 132.192 1.00 76.39  ? 284 PHE A CB  1 
ATOM   5674 C  CG  . PHE B 2 293 ? 178.495 161.500 133.533 1.00 75.73  ? 284 PHE A CG  1 
ATOM   5675 C  CD1 . PHE B 2 293 ? 179.374 161.703 134.576 1.00 78.18  ? 284 PHE A CD1 1 
ATOM   5676 C  CD2 . PHE B 2 293 ? 177.147 161.688 133.757 1.00 76.11  ? 284 PHE A CD2 1 
ATOM   5677 C  CE1 . PHE B 2 293 ? 178.919 162.094 135.815 1.00 78.89  ? 284 PHE A CE1 1 
ATOM   5678 C  CE2 . PHE B 2 293 ? 176.687 162.079 134.993 1.00 75.56  ? 284 PHE A CE2 1 
ATOM   5679 C  CZ  . PHE B 2 293 ? 177.575 162.281 136.024 1.00 75.46  ? 284 PHE A CZ  1 
ATOM   5680 N  N   . PHE B 2 294 ? 177.532 158.297 132.309 1.00 78.10  ? 285 PHE A N   1 
ATOM   5681 C  CA  . PHE B 2 294 ? 176.606 157.412 133.001 1.00 76.97  ? 285 PHE A CA  1 
ATOM   5682 C  C   . PHE B 2 294 ? 177.182 156.017 133.166 1.00 82.35  ? 285 PHE A C   1 
ATOM   5683 O  O   . PHE B 2 294 ? 176.918 155.361 134.177 1.00 87.48  ? 285 PHE A O   1 
ATOM   5684 C  CB  . PHE B 2 294 ? 175.271 157.366 132.272 1.00 73.35  ? 285 PHE A CB  1 
ATOM   5685 C  CG  . PHE B 2 294 ? 174.351 158.482 132.651 1.00 72.21  ? 285 PHE A CG  1 
ATOM   5686 C  CD1 . PHE B 2 294 ? 174.478 159.109 133.872 1.00 67.13  ? 285 PHE A CD1 1 
ATOM   5687 C  CD2 . PHE B 2 294 ? 173.365 158.909 131.790 1.00 74.54  ? 285 PHE A CD2 1 
ATOM   5688 C  CE1 . PHE B 2 294 ? 173.643 160.135 134.225 1.00 63.00  ? 285 PHE A CE1 1 
ATOM   5689 C  CE2 . PHE B 2 294 ? 172.526 159.935 132.145 1.00 69.39  ? 285 PHE A CE2 1 
ATOM   5690 C  CZ  . PHE B 2 294 ? 172.666 160.546 133.363 1.00 63.49  ? 285 PHE A CZ  1 
ATOM   5691 N  N   . ASN B 2 295 ? 177.978 155.548 132.205 1.00 82.84  ? 286 ASN A N   1 
ATOM   5692 C  CA  . ASN B 2 295 ? 178.662 154.274 132.396 1.00 84.39  ? 286 ASN A CA  1 
ATOM   5693 C  C   . ASN B 2 295 ? 179.628 154.345 133.572 1.00 83.41  ? 286 ASN A C   1 
ATOM   5694 O  O   . ASN B 2 295 ? 179.717 153.406 134.371 1.00 84.11  ? 286 ASN A O   1 
ATOM   5695 C  CB  . ASN B 2 295 ? 179.393 153.873 131.118 1.00 89.13  ? 286 ASN A CB  1 
ATOM   5696 C  CG  . ASN B 2 295 ? 178.488 153.169 130.131 1.00 93.89  ? 286 ASN A CG  1 
ATOM   5697 O  OD1 . ASN B 2 295 ? 177.837 152.181 130.467 1.00 97.09  ? 286 ASN A OD1 1 
ATOM   5698 N  ND2 . ASN B 2 295 ? 178.440 153.675 128.906 1.00 91.48  ? 286 ASN A ND2 1 
ATOM   5699 N  N   . GLU B 2 296 ? 180.355 155.458 133.698 1.00 83.58  ? 287 GLU A N   1 
ATOM   5700 C  CA  . GLU B 2 296 ? 181.265 155.622 134.827 1.00 86.17  ? 287 GLU A CA  1 
ATOM   5701 C  C   . GLU B 2 296 ? 180.512 155.651 136.150 1.00 85.84  ? 287 GLU A C   1 
ATOM   5702 O  O   . GLU B 2 296 ? 180.929 155.014 137.125 1.00 88.47  ? 287 GLU A O   1 
ATOM   5703 C  CB  . GLU B 2 296 ? 182.083 156.899 134.651 1.00 91.21  ? 287 GLU A CB  1 
ATOM   5704 C  CG  . GLU B 2 296 ? 182.939 157.263 135.847 1.00 94.52  ? 287 GLU A CG  1 
ATOM   5705 C  CD  . GLU B 2 296 ? 184.054 156.271 136.090 1.00 100.11 ? 287 GLU A CD  1 
ATOM   5706 O  OE1 . GLU B 2 296 ? 183.814 155.265 136.790 1.00 99.39  ? 287 GLU A OE1 1 
ATOM   5707 O  OE2 . GLU B 2 296 ? 185.168 156.491 135.574 1.00 100.90 ? 287 GLU A OE2 1 
ATOM   5708 N  N   . VAL B 2 297 ? 179.398 156.385 136.201 1.00 82.37  ? 288 VAL A N   1 
ATOM   5709 C  CA  . VAL B 2 297 ? 178.600 156.440 137.423 1.00 78.42  ? 288 VAL A CA  1 
ATOM   5710 C  C   . VAL B 2 297 ? 178.079 155.055 137.776 1.00 82.98  ? 288 VAL A C   1 
ATOM   5711 O  O   . VAL B 2 297 ? 178.082 154.649 138.943 1.00 84.73  ? 288 VAL A O   1 
ATOM   5712 C  CB  . VAL B 2 297 ? 177.448 157.446 137.269 1.00 71.57  ? 288 VAL A CB  1 
ATOM   5713 C  CG1 . VAL B 2 297 ? 176.510 157.342 138.442 1.00 73.59  ? 288 VAL A CG1 1 
ATOM   5714 C  CG2 . VAL B 2 297 ? 177.985 158.849 137.148 1.00 74.96  ? 288 VAL A CG2 1 
ATOM   5715 N  N   . LEU B 2 298 ? 177.624 154.310 136.769 1.00 83.90  ? 289 LEU A N   1 
ATOM   5716 C  CA  . LEU B 2 298 ? 177.137 152.955 136.992 1.00 82.70  ? 289 LEU A CA  1 
ATOM   5717 C  C   . LEU B 2 298 ? 178.235 152.060 137.546 1.00 87.29  ? 289 LEU A C   1 
ATOM   5718 O  O   . LEU B 2 298 ? 177.996 151.264 138.461 1.00 86.93  ? 289 LEU A O   1 
ATOM   5719 C  CB  . LEU B 2 298 ? 176.601 152.393 135.680 1.00 84.65  ? 289 LEU A CB  1 
ATOM   5720 C  CG  . LEU B 2 298 ? 175.090 152.344 135.512 1.00 85.87  ? 289 LEU A CG  1 
ATOM   5721 C  CD1 . LEU B 2 298 ? 174.742 151.273 134.511 1.00 87.67  ? 289 LEU A CD1 1 
ATOM   5722 C  CD2 . LEU B 2 298 ? 174.423 152.074 136.846 1.00 87.55  ? 289 LEU A CD2 1 
ATOM   5723 N  N   . ARG B 2 299 ? 179.444 152.169 136.994 1.00 91.78  ? 290 ARG A N   1 
ATOM   5724 C  CA  . ARG B 2 299 ? 180.558 151.371 137.492 1.00 92.17  ? 290 ARG A CA  1 
ATOM   5725 C  C   . ARG B 2 299 ? 180.878 151.716 138.939 1.00 92.65  ? 290 ARG A C   1 
ATOM   5726 O  O   . ARG B 2 299 ? 181.103 150.822 139.763 1.00 98.16  ? 290 ARG A O   1 
ATOM   5727 C  CB  . ARG B 2 299 ? 181.787 151.577 136.609 1.00 93.41  ? 290 ARG A CB  1 
ATOM   5728 C  CG  . ARG B 2 299 ? 183.094 151.178 137.268 1.00 94.67  ? 290 ARG A CG  1 
ATOM   5729 C  CD  . ARG B 2 299 ? 184.243 152.010 136.740 1.00 98.26  ? 290 ARG A CD  1 
ATOM   5730 N  NE  . ARG B 2 299 ? 184.098 152.278 135.315 1.00 103.92 ? 290 ARG A NE  1 
ATOM   5731 C  CZ  . ARG B 2 299 ? 184.444 151.432 134.355 1.00 107.14 ? 290 ARG A CZ  1 
ATOM   5732 N  NH1 . ARG B 2 299 ? 184.970 150.251 134.632 1.00 108.42 ? 290 ARG A NH1 1 
ATOM   5733 N  NH2 . ARG B 2 299 ? 184.256 151.780 133.085 1.00 104.14 ? 290 ARG A NH2 1 
ATOM   5734 N  N   . GLN B 2 300 ? 180.887 153.006 139.274 1.00 89.55  ? 291 GLN A N   1 
ATOM   5735 C  CA  . GLN B 2 300 ? 181.217 153.411 140.635 1.00 87.81  ? 291 GLN A CA  1 
ATOM   5736 C  C   . GLN B 2 300 ? 180.122 153.074 141.636 1.00 87.18  ? 291 GLN A C   1 
ATOM   5737 O  O   . GLN B 2 300 ? 180.342 153.237 142.839 1.00 85.00  ? 291 GLN A O   1 
ATOM   5738 C  CB  . GLN B 2 300 ? 181.516 154.907 140.678 1.00 86.98  ? 291 GLN A CB  1 
ATOM   5739 C  CG  . GLN B 2 300 ? 182.725 155.305 139.857 1.00 89.04  ? 291 GLN A CG  1 
ATOM   5740 C  CD  . GLN B 2 300 ? 183.931 155.611 140.711 1.00 91.08  ? 291 GLN A CD  1 
ATOM   5741 O  OE1 . GLN B 2 300 ? 183.850 156.379 141.668 1.00 90.61  ? 291 GLN A OE1 1 
ATOM   5742 N  NE2 . GLN B 2 300 ? 185.063 155.008 140.371 1.00 91.86  ? 291 GLN A NE2 1 
ATOM   5743 N  N   . ASN B 2 301 ? 178.957 152.622 141.169 1.00 90.22  ? 292 ASN A N   1 
ATOM   5744 C  CA  . ASN B 2 301 ? 177.847 152.217 142.035 1.00 93.43  ? 292 ASN A CA  1 
ATOM   5745 C  C   . ASN B 2 301 ? 177.397 153.364 142.939 1.00 94.43  ? 292 ASN A C   1 
ATOM   5746 O  O   . ASN B 2 301 ? 177.203 153.202 144.144 1.00 96.81  ? 292 ASN A O   1 
ATOM   5747 C  CB  . ASN B 2 301 ? 178.208 150.972 142.850 1.00 96.17  ? 292 ASN A CB  1 
ATOM   5748 C  CG  . ASN B 2 301 ? 177.676 149.695 142.222 1.00 102.88 ? 292 ASN A CG  1 
ATOM   5749 O  OD1 . ASN B 2 301 ? 176.610 149.703 141.608 1.00 103.07 ? 292 ASN A OD1 1 
ATOM   5750 N  ND2 . ASN B 2 301 ? 178.412 148.594 142.362 1.00 109.60 ? 292 ASN A ND2 1 
ATOM   5751 N  N   . PHE B 2 302 ? 177.227 154.535 142.334 1.00 92.06  ? 293 PHE A N   1 
ATOM   5752 C  CA  . PHE B 2 302 ? 176.730 155.716 143.025 1.00 83.63  ? 293 PHE A CA  1 
ATOM   5753 C  C   . PHE B 2 302 ? 175.215 155.757 142.897 1.00 82.50  ? 293 PHE A C   1 
ATOM   5754 O  O   . PHE B 2 302 ? 174.688 155.921 141.793 1.00 85.44  ? 293 PHE A O   1 
ATOM   5755 C  CB  . PHE B 2 302 ? 177.362 156.974 142.435 1.00 79.67  ? 293 PHE A CB  1 
ATOM   5756 C  CG  . PHE B 2 302 ? 176.579 158.223 142.685 1.00 76.18  ? 293 PHE A CG  1 
ATOM   5757 C  CD1 . PHE B 2 302 ? 176.583 158.817 143.928 1.00 81.48  ? 293 PHE A CD1 1 
ATOM   5758 C  CD2 . PHE B 2 302 ? 175.856 158.815 141.673 1.00 73.42  ? 293 PHE A CD2 1 
ATOM   5759 C  CE1 . PHE B 2 302 ? 175.872 159.972 144.158 1.00 79.95  ? 293 PHE A CE1 1 
ATOM   5760 C  CE2 . PHE B 2 302 ? 175.144 159.969 141.901 1.00 75.07  ? 293 PHE A CE2 1 
ATOM   5761 C  CZ  . PHE B 2 302 ? 175.153 160.548 143.143 1.00 76.99  ? 293 PHE A CZ  1 
ATOM   5762 N  N   . THR B 2 303 ? 174.515 155.616 144.017 1.00 84.96  ? 294 THR A N   1 
ATOM   5763 C  CA  . THR B 2 303 ? 173.068 155.477 144.005 1.00 90.75  ? 294 THR A CA  1 
ATOM   5764 C  C   . THR B 2 303 ? 172.431 156.489 144.942 1.00 90.97  ? 294 THR A C   1 
ATOM   5765 O  O   . THR B 2 303 ? 173.033 156.911 145.932 1.00 94.25  ? 294 THR A O   1 
ATOM   5766 C  CB  . THR B 2 303 ? 172.634 154.061 144.415 1.00 95.51  ? 294 THR A CB  1 
ATOM   5767 O  OG1 . THR B 2 303 ? 171.203 153.979 144.424 1.00 97.18  ? 294 THR A OG1 1 
ATOM   5768 C  CG2 . THR B 2 303 ? 173.158 153.720 145.802 1.00 90.41  ? 294 THR A CG2 1 
ATOM   5769 N  N   . GLY B 2 304 ? 171.206 156.876 144.613 1.00 85.02  ? 295 GLY A N   1 
ATOM   5770 C  CA  . GLY B 2 304 ? 170.396 157.687 145.486 1.00 84.90  ? 295 GLY A CA  1 
ATOM   5771 C  C   . GLY B 2 304 ? 170.346 159.165 145.179 1.00 81.61  ? 295 GLY A C   1 
ATOM   5772 O  O   . GLY B 2 304 ? 170.353 159.968 146.116 1.00 86.15  ? 295 GLY A O   1 
ATOM   5773 N  N   . ALA B 2 305 ? 170.293 159.552 143.909 1.00 74.05  ? 296 ALA A N   1 
ATOM   5774 C  CA  . ALA B 2 305 ? 170.215 160.954 143.533 1.00 69.10  ? 296 ALA A CA  1 
ATOM   5775 C  C   . ALA B 2 305 ? 169.032 161.169 142.604 1.00 65.38  ? 296 ALA A C   1 
ATOM   5776 O  O   . ALA B 2 305 ? 168.605 160.254 141.898 1.00 70.19  ? 296 ALA A O   1 
ATOM   5777 C  CB  . ALA B 2 305 ? 171.501 161.428 142.856 1.00 70.87  ? 296 ALA A CB  1 
ATOM   5778 N  N   . VAL B 2 306 ? 168.498 162.384 142.620 1.00 58.93  ? 297 VAL A N   1 
ATOM   5779 C  CA  . VAL B 2 306 ? 167.371 162.765 141.779 1.00 56.41  ? 297 VAL A CA  1 
ATOM   5780 C  C   . VAL B 2 306 ? 167.943 163.531 140.595 1.00 55.22  ? 297 VAL A C   1 
ATOM   5781 O  O   . VAL B 2 306 ? 168.117 164.748 140.655 1.00 59.95  ? 297 VAL A O   1 
ATOM   5782 C  CB  . VAL B 2 306 ? 166.350 163.604 142.547 1.00 52.58  ? 297 VAL A CB  1 
ATOM   5783 C  CG1 . VAL B 2 306 ? 165.168 163.935 141.662 1.00 51.92  ? 297 VAL A CG1 1 
ATOM   5784 C  CG2 . VAL B 2 306 ? 165.902 162.876 143.790 1.00 59.67  ? 297 VAL A CG2 1 
ATOM   5785 N  N   . TRP B 2 307 ? 168.236 162.825 139.512 1.00 51.38  ? 298 TRP A N   1 
ATOM   5786 C  CA  . TRP B 2 307 ? 168.805 163.467 138.338 1.00 50.91  ? 298 TRP A CA  1 
ATOM   5787 C  C   . TRP B 2 307 ? 167.746 164.309 137.648 1.00 51.54  ? 298 TRP A C   1 
ATOM   5788 O  O   . TRP B 2 307 ? 166.635 163.838 137.402 1.00 58.33  ? 298 TRP A O   1 
ATOM   5789 C  CB  . TRP B 2 307 ? 169.360 162.423 137.376 1.00 53.85  ? 298 TRP A CB  1 
ATOM   5790 C  CG  . TRP B 2 307 ? 170.384 161.545 137.989 1.00 56.60  ? 298 TRP A CG  1 
ATOM   5791 C  CD1 . TRP B 2 307 ? 170.165 160.406 138.694 1.00 60.50  ? 298 TRP A CD1 1 
ATOM   5792 C  CD2 . TRP B 2 307 ? 171.798 161.734 137.960 1.00 57.68  ? 298 TRP A CD2 1 
ATOM   5793 N  NE1 . TRP B 2 307 ? 171.355 159.869 139.106 1.00 60.65  ? 298 TRP A NE1 1 
ATOM   5794 C  CE2 . TRP B 2 307 ? 172.374 160.670 138.667 1.00 59.86  ? 298 TRP A CE2 1 
ATOM   5795 C  CE3 . TRP B 2 307 ? 172.632 162.701 137.403 1.00 59.29  ? 298 TRP A CE3 1 
ATOM   5796 C  CZ2 . TRP B 2 307 ? 173.744 160.543 138.830 1.00 64.15  ? 298 TRP A CZ2 1 
ATOM   5797 C  CZ3 . TRP B 2 307 ? 173.988 162.575 137.567 1.00 63.84  ? 298 TRP A CZ3 1 
ATOM   5798 C  CH2 . TRP B 2 307 ? 174.533 161.505 138.274 1.00 65.38  ? 298 TRP A CH2 1 
ATOM   5799 N  N   . ILE B 2 308 ? 168.091 165.553 137.336 1.00 48.19  ? 299 ILE A N   1 
ATOM   5800 C  CA  . ILE B 2 308 ? 167.206 166.471 136.630 1.00 47.25  ? 299 ILE A CA  1 
ATOM   5801 C  C   . ILE B 2 308 ? 167.838 166.772 135.282 1.00 52.53  ? 299 ILE A C   1 
ATOM   5802 O  O   . ILE B 2 308 ? 168.995 167.200 135.214 1.00 62.04  ? 299 ILE A O   1 
ATOM   5803 C  CB  . ILE B 2 308 ? 166.968 167.760 137.427 1.00 48.02  ? 299 ILE A CB  1 
ATOM   5804 C  CG1 . ILE B 2 308 ? 166.022 167.498 138.594 1.00 48.50  ? 299 ILE A CG1 1 
ATOM   5805 C  CG2 . ILE B 2 308 ? 166.401 168.832 136.533 1.00 51.70  ? 299 ILE A CG2 1 
ATOM   5806 C  CD1 . ILE B 2 308 ? 165.733 168.718 139.417 1.00 46.31  ? 299 ILE A CD1 1 
ATOM   5807 N  N   . ALA B 2 309 ? 167.085 166.558 134.214 1.00 52.19  ? 300 ALA A N   1 
ATOM   5808 C  CA  . ALA B 2 309 ? 167.609 166.659 132.863 1.00 57.76  ? 300 ALA A CA  1 
ATOM   5809 C  C   . ALA B 2 309 ? 167.218 167.982 132.224 1.00 61.36  ? 300 ALA A C   1 
ATOM   5810 O  O   . ALA B 2 309 ? 166.179 168.565 132.541 1.00 65.90  ? 300 ALA A O   1 
ATOM   5811 C  CB  . ALA B 2 309 ? 167.097 165.510 131.996 1.00 62.37  ? 300 ALA A CB  1 
ATOM   5812 N  N   . SER B 2 310 ? 168.066 168.455 131.321 1.00 64.59  ? 301 SER A N   1 
ATOM   5813 C  CA  . SER B 2 310 ? 167.693 169.570 130.472 1.00 71.80  ? 301 SER A CA  1 
ATOM   5814 C  C   . SER B 2 310 ? 166.904 169.045 129.277 1.00 75.00  ? 301 SER A C   1 
ATOM   5815 O  O   . SER B 2 310 ? 166.705 167.840 129.113 1.00 79.51  ? 301 SER A O   1 
ATOM   5816 C  CB  . SER B 2 310 ? 168.932 170.339 130.029 1.00 75.64  ? 301 SER A CB  1 
ATOM   5817 O  OG  . SER B 2 310 ? 168.569 171.542 129.379 1.00 84.58  ? 301 SER A OG  1 
ATOM   5818 N  N   . GLU B 2 311 ? 166.445 169.956 128.420 1.00 72.39  ? 302 GLU A N   1 
ATOM   5819 C  CA  . GLU B 2 311 ? 165.659 169.540 127.266 1.00 71.36  ? 302 GLU A CA  1 
ATOM   5820 C  C   . GLU B 2 311 ? 166.484 168.757 126.255 1.00 78.15  ? 302 GLU A C   1 
ATOM   5821 O  O   . GLU B 2 311 ? 165.908 168.129 125.361 1.00 81.34  ? 302 GLU A O   1 
ATOM   5822 C  CB  . GLU B 2 311 ? 165.024 170.760 126.599 1.00 74.71  ? 302 GLU A CB  1 
ATOM   5823 C  CG  . GLU B 2 311 ? 165.997 171.884 126.289 1.00 81.48  ? 302 GLU A CG  1 
ATOM   5824 C  CD  . GLU B 2 311 ? 166.679 171.723 124.946 1.00 86.36  ? 302 GLU A CD  1 
ATOM   5825 O  OE1 . GLU B 2 311 ? 166.259 170.845 124.167 1.00 90.07  ? 302 GLU A OE1 1 
ATOM   5826 O  OE2 . GLU B 2 311 ? 167.635 172.476 124.666 1.00 82.88  ? 302 GLU A OE2 1 
ATOM   5827 N  N   . SER B 2 312 ? 167.814 168.782 126.371 1.00 77.85  ? 303 SER A N   1 
ATOM   5828 C  CA  . SER B 2 312 ? 168.655 168.091 125.399 1.00 81.35  ? 303 SER A CA  1 
ATOM   5829 C  C   . SER B 2 312 ? 168.437 166.586 125.442 1.00 80.77  ? 303 SER A C   1 
ATOM   5830 O  O   . SER B 2 312 ? 168.318 165.940 124.396 1.00 87.49  ? 303 SER A O   1 
ATOM   5831 C  CB  . SER B 2 312 ? 170.124 168.418 125.646 1.00 83.37  ? 303 SER A CB  1 
ATOM   5832 O  OG  . SER B 2 312 ? 170.357 169.806 125.524 1.00 89.00  ? 303 SER A OG  1 
ATOM   5833 N  N   . TRP B 2 313 ? 168.379 166.008 126.639 1.00 74.73  ? 304 TRP A N   1 
ATOM   5834 C  CA  . TRP B 2 313 ? 168.256 164.565 126.785 1.00 75.74  ? 304 TRP A CA  1 
ATOM   5835 C  C   . TRP B 2 313 ? 167.058 164.151 127.624 1.00 72.87  ? 304 TRP A C   1 
ATOM   5836 O  O   . TRP B 2 313 ? 166.957 162.980 127.999 1.00 73.80  ? 304 TRP A O   1 
ATOM   5837 C  CB  . TRP B 2 313 ? 169.538 163.981 127.384 1.00 77.88  ? 304 TRP A CB  1 
ATOM   5838 C  CG  . TRP B 2 313 ? 169.868 164.493 128.748 1.00 71.81  ? 304 TRP A CG  1 
ATOM   5839 C  CD1 . TRP B 2 313 ? 170.344 165.727 129.061 1.00 71.35  ? 304 TRP A CD1 1 
ATOM   5840 C  CD2 . TRP B 2 313 ? 169.762 163.779 129.984 1.00 65.26  ? 304 TRP A CD2 1 
ATOM   5841 N  NE1 . TRP B 2 313 ? 170.538 165.830 130.414 1.00 70.27  ? 304 TRP A NE1 1 
ATOM   5842 C  CE2 . TRP B 2 313 ? 170.189 164.645 131.003 1.00 65.83  ? 304 TRP A CE2 1 
ATOM   5843 C  CE3 . TRP B 2 313 ? 169.350 162.492 130.327 1.00 65.23  ? 304 TRP A CE3 1 
ATOM   5844 C  CZ2 . TRP B 2 313 ? 170.213 164.266 132.340 1.00 62.26  ? 304 TRP A CZ2 1 
ATOM   5845 C  CZ3 . TRP B 2 313 ? 169.372 162.121 131.655 1.00 62.33  ? 304 TRP A CZ3 1 
ATOM   5846 C  CH2 . TRP B 2 313 ? 169.798 163.004 132.644 1.00 59.81  ? 304 TRP A CH2 1 
ATOM   5847 N  N   . ALA B 2 314 ? 166.142 165.071 127.922 1.00 71.53  ? 305 ALA A N   1 
ATOM   5848 C  CA  . ALA B 2 314 ? 164.967 164.705 128.698 1.00 68.81  ? 305 ALA A CA  1 
ATOM   5849 C  C   . ALA B 2 314 ? 164.058 163.749 127.946 1.00 69.98  ? 305 ALA A C   1 
ATOM   5850 O  O   . ALA B 2 314 ? 163.216 163.097 128.569 1.00 72.14  ? 305 ALA A O   1 
ATOM   5851 C  CB  . ALA B 2 314 ? 164.183 165.954 129.093 1.00 68.26  ? 305 ALA A CB  1 
ATOM   5852 N  N   . ILE B 2 315 ? 164.203 163.654 126.628 1.00 72.24  ? 306 ILE A N   1 
ATOM   5853 C  CA  . ILE B 2 315 ? 163.333 162.813 125.819 1.00 73.60  ? 306 ILE A CA  1 
ATOM   5854 C  C   . ILE B 2 315 ? 164.165 161.911 124.922 1.00 76.45  ? 306 ILE A C   1 
ATOM   5855 O  O   . ILE B 2 315 ? 163.679 161.427 123.895 1.00 79.26  ? 306 ILE A O   1 
ATOM   5856 C  CB  . ILE B 2 315 ? 162.369 163.667 124.980 1.00 74.96  ? 306 ILE A CB  1 
ATOM   5857 C  CG1 . ILE B 2 315 ? 163.159 164.677 124.148 1.00 81.32  ? 306 ILE A CG1 1 
ATOM   5858 C  CG2 . ILE B 2 315 ? 161.376 164.374 125.875 1.00 71.21  ? 306 ILE A CG2 1 
ATOM   5859 C  CD1 . ILE B 2 315 ? 162.329 165.816 123.617 1.00 86.17  ? 306 ILE A CD1 1 
ATOM   5860 N  N   . ASP B 2 316 ? 165.414 161.677 125.295 1.00 78.34  ? 307 ASP A N   1 
ATOM   5861 C  CA  . ASP B 2 316 ? 166.298 160.871 124.461 1.00 80.95  ? 307 ASP A CA  1 
ATOM   5862 C  C   . ASP B 2 316 ? 165.912 159.403 124.557 1.00 83.85  ? 307 ASP A C   1 
ATOM   5863 O  O   . ASP B 2 316 ? 166.021 158.815 125.640 1.00 85.35  ? 307 ASP A O   1 
ATOM   5864 C  CB  . ASP B 2 316 ? 167.744 161.058 124.889 1.00 80.91  ? 307 ASP A CB  1 
ATOM   5865 C  CG  . ASP B 2 316 ? 168.716 160.754 123.779 1.00 86.20  ? 307 ASP A CG  1 
ATOM   5866 O  OD1 . ASP B 2 316 ? 168.260 160.539 122.639 1.00 89.39  ? 307 ASP A OD1 1 
ATOM   5867 O  OD2 . ASP B 2 316 ? 169.934 160.715 124.044 1.00 90.10  ? 307 ASP A OD2 1 
ATOM   5868 N  N   . PRO B 2 317 ? 165.482 158.768 123.468 1.00 83.83  ? 308 PRO A N   1 
ATOM   5869 C  CA  . PRO B 2 317 ? 165.027 157.377 123.563 1.00 85.18  ? 308 PRO A CA  1 
ATOM   5870 C  C   . PRO B 2 317 ? 166.175 156.385 123.600 1.00 88.74  ? 308 PRO A C   1 
ATOM   5871 O  O   . PRO B 2 317 ? 166.096 155.363 124.287 1.00 93.01  ? 308 PRO A O   1 
ATOM   5872 C  CB  . PRO B 2 317 ? 164.174 157.206 122.303 1.00 84.97  ? 308 PRO A CB  1 
ATOM   5873 C  CG  . PRO B 2 317 ? 164.753 158.163 121.330 1.00 82.54  ? 308 PRO A CG  1 
ATOM   5874 C  CD  . PRO B 2 317 ? 165.323 159.315 122.111 1.00 82.59  ? 308 PRO A CD  1 
ATOM   5875 N  N   . VAL B 2 318 ? 167.250 156.676 122.870 1.00 88.07  ? 309 VAL A N   1 
ATOM   5876 C  CA  . VAL B 2 318 ? 168.383 155.759 122.841 1.00 92.71  ? 309 VAL A CA  1 
ATOM   5877 C  C   . VAL B 2 318 ? 169.096 155.750 124.188 1.00 94.23  ? 309 VAL A C   1 
ATOM   5878 O  O   . VAL B 2 318 ? 169.577 154.706 124.645 1.00 96.53  ? 309 VAL A O   1 
ATOM   5879 C  CB  . VAL B 2 318 ? 169.328 156.119 121.681 1.00 92.45  ? 309 VAL A CB  1 
ATOM   5880 C  CG1 . VAL B 2 318 ? 169.670 157.598 121.705 1.00 92.56  ? 309 VAL A CG1 1 
ATOM   5881 C  CG2 . VAL B 2 318 ? 170.574 155.252 121.710 1.00 91.00  ? 309 VAL A CG2 1 
ATOM   5882 N  N   . LEU B 2 319 ? 169.177 156.907 124.846 1.00 91.33  ? 310 LEU A N   1 
ATOM   5883 C  CA  . LEU B 2 319 ? 169.737 156.950 126.193 1.00 90.99  ? 310 LEU A CA  1 
ATOM   5884 C  C   . LEU B 2 319 ? 168.812 156.274 127.197 1.00 91.80  ? 310 LEU A C   1 
ATOM   5885 O  O   . LEU B 2 319 ? 169.274 155.556 128.090 1.00 90.70  ? 310 LEU A O   1 
ATOM   5886 C  CB  . LEU B 2 319 ? 170.004 158.396 126.601 1.00 85.89  ? 310 LEU A CB  1 
ATOM   5887 C  CG  . LEU B 2 319 ? 170.998 158.596 127.739 1.00 79.99  ? 310 LEU A CG  1 
ATOM   5888 C  CD1 . LEU B 2 319 ? 171.914 159.757 127.428 1.00 83.97  ? 310 LEU A CD1 1 
ATOM   5889 C  CD2 . LEU B 2 319 ? 170.263 158.832 129.035 1.00 77.17  ? 310 LEU A CD2 1 
ATOM   5890 N  N   . HIS B 2 320 ? 167.503 156.494 127.064 1.00 90.64  ? 311 HIS A N   1 
ATOM   5891 C  CA  . HIS B 2 320 ? 166.544 155.874 127.972 1.00 86.52  ? 311 HIS A CA  1 
ATOM   5892 C  C   . HIS B 2 320 ? 166.492 154.364 127.787 1.00 91.44  ? 311 HIS A C   1 
ATOM   5893 O  O   . HIS B 2 320 ? 166.072 153.644 128.698 1.00 92.39  ? 311 HIS A O   1 
ATOM   5894 C  CB  . HIS B 2 320 ? 165.164 156.495 127.763 1.00 81.57  ? 311 HIS A CB  1 
ATOM   5895 C  CG  . HIS B 2 320 ? 164.058 155.762 128.450 1.00 83.17  ? 311 HIS A CG  1 
ATOM   5896 N  ND1 . HIS B 2 320 ? 164.125 155.382 129.771 1.00 86.53  ? 311 HIS A ND1 1 
ATOM   5897 C  CD2 . HIS B 2 320 ? 162.853 155.345 128.000 1.00 86.27  ? 311 HIS A CD2 1 
ATOM   5898 C  CE1 . HIS B 2 320 ? 163.010 154.758 130.104 1.00 86.45  ? 311 HIS A CE1 1 
ATOM   5899 N  NE2 . HIS B 2 320 ? 162.220 154.723 129.048 1.00 86.63  ? 311 HIS A NE2 1 
ATOM   5900 N  N   . ASN B 2 321 ? 166.925 153.866 126.631 1.00 94.96  ? 312 ASN A N   1 
ATOM   5901 C  CA  . ASN B 2 321 ? 166.921 152.432 126.381 1.00 98.58  ? 312 ASN A CA  1 
ATOM   5902 C  C   . ASN B 2 321 ? 167.959 151.678 127.203 1.00 101.79 ? 312 ASN A C   1 
ATOM   5903 O  O   . ASN B 2 321 ? 167.929 150.443 127.211 1.00 107.79 ? 312 ASN A O   1 
ATOM   5904 C  CB  . ASN B 2 321 ? 167.147 152.163 124.892 1.00 104.03 ? 312 ASN A CB  1 
ATOM   5905 C  CG  . ASN B 2 321 ? 166.980 150.704 124.535 1.00 115.21 ? 312 ASN A CG  1 
ATOM   5906 O  OD1 . ASN B 2 321 ? 165.863 150.211 124.387 1.00 117.51 ? 312 ASN A OD1 1 
ATOM   5907 N  ND2 . ASN B 2 321 ? 168.097 149.999 124.404 1.00 119.75 ? 312 ASN A ND2 1 
ATOM   5908 N  N   . LEU B 2 322 ? 168.865 152.375 127.893 1.00 94.83  ? 313 LEU A N   1 
ATOM   5909 C  CA  . LEU B 2 322 ? 169.923 151.696 128.635 1.00 95.38  ? 313 LEU A CA  1 
ATOM   5910 C  C   . LEU B 2 322 ? 169.348 150.708 129.643 1.00 99.61  ? 313 LEU A C   1 
ATOM   5911 O  O   . LEU B 2 322 ? 169.841 149.583 129.780 1.00 102.54 ? 313 LEU A O   1 
ATOM   5912 C  CB  . LEU B 2 322 ? 170.817 152.720 129.334 1.00 91.93  ? 313 LEU A CB  1 
ATOM   5913 C  CG  . LEU B 2 322 ? 172.181 152.946 128.682 1.00 95.17  ? 313 LEU A CG  1 
ATOM   5914 C  CD1 . LEU B 2 322 ? 172.033 153.109 127.178 1.00 95.96  ? 313 LEU A CD1 1 
ATOM   5915 C  CD2 . LEU B 2 322 ? 172.893 154.142 129.295 1.00 92.30  ? 313 LEU A CD2 1 
ATOM   5916 N  N   . THR B 2 323 ? 168.317 151.125 130.374 1.00 98.03  ? 314 THR A N   1 
ATOM   5917 C  CA  . THR B 2 323 ? 167.524 150.317 131.302 1.00 100.60 ? 314 THR A CA  1 
ATOM   5918 C  C   . THR B 2 323 ? 168.357 149.877 132.505 1.00 97.20  ? 314 THR A C   1 
ATOM   5919 O  O   . THR B 2 323 ? 167.823 149.221 133.404 1.00 96.19  ? 314 THR A O   1 
ATOM   5920 C  CB  . THR B 2 323 ? 166.896 149.084 130.627 1.00 106.30 ? 314 THR A CB  1 
ATOM   5921 O  OG1 . THR B 2 323 ? 166.430 149.446 129.323 1.00 106.56 ? 314 THR A OG1 1 
ATOM   5922 C  CG2 . THR B 2 323 ? 165.700 148.571 131.422 1.00 103.02 ? 314 THR A CG2 1 
ATOM   5923 N  N   . GLU B 2 324 ? 169.643 150.212 132.560 1.00 94.75  ? 315 GLU A N   1 
ATOM   5924 C  CA  . GLU B 2 324 ? 170.466 149.926 133.723 1.00 95.89  ? 315 GLU A CA  1 
ATOM   5925 C  C   . GLU B 2 324 ? 170.672 151.165 134.585 1.00 91.90  ? 315 GLU A C   1 
ATOM   5926 O  O   . GLU B 2 324 ? 171.467 151.134 135.528 1.00 92.28  ? 315 GLU A O   1 
ATOM   5927 C  CB  . GLU B 2 324 ? 171.807 149.335 133.283 1.00 97.19  ? 315 GLU A CB  1 
ATOM   5928 C  CG  . GLU B 2 324 ? 172.558 148.580 134.373 1.00 101.62 ? 315 GLU A CG  1 
ATOM   5929 C  CD  . GLU B 2 324 ? 171.827 147.342 134.849 1.00 109.55 ? 315 GLU A CD  1 
ATOM   5930 O  OE1 . GLU B 2 324 ? 170.928 146.860 134.130 1.00 112.27 ? 315 GLU A OE1 1 
ATOM   5931 O  OE2 . GLU B 2 324 ? 172.152 146.850 135.950 1.00 112.33 ? 315 GLU A OE2 1 
ATOM   5932 N  N   . LEU B 2 325 ? 169.972 152.254 134.279 1.00 86.55  ? 316 LEU A N   1 
ATOM   5933 C  CA  . LEU B 2 325 ? 169.990 153.456 135.096 1.00 82.17  ? 316 LEU A CA  1 
ATOM   5934 C  C   . LEU B 2 325 ? 168.866 153.480 136.120 1.00 81.76  ? 316 LEU A C   1 
ATOM   5935 O  O   . LEU B 2 325 ? 168.731 154.464 136.850 1.00 82.99  ? 316 LEU A O   1 
ATOM   5936 C  CB  . LEU B 2 325 ? 169.911 154.702 134.214 1.00 77.19  ? 316 LEU A CB  1 
ATOM   5937 C  CG  . LEU B 2 325 ? 170.661 154.665 132.887 1.00 75.21  ? 316 LEU A CG  1 
ATOM   5938 C  CD1 . LEU B 2 325 ? 170.254 155.835 132.017 1.00 69.05  ? 316 LEU A CD1 1 
ATOM   5939 C  CD2 . LEU B 2 325 ? 172.151 154.675 133.130 1.00 78.04  ? 316 LEU A CD2 1 
ATOM   5940 N  N   . ARG B 2 326 ? 168.053 152.425 136.191 1.00 82.47  ? 317 ARG A N   1 
ATOM   5941 C  CA  . ARG B 2 326 ? 166.989 152.388 137.187 1.00 83.85  ? 317 ARG A CA  1 
ATOM   5942 C  C   . ARG B 2 326 ? 167.534 152.425 138.604 1.00 87.78  ? 317 ARG A C   1 
ATOM   5943 O  O   . ARG B 2 326 ? 166.822 152.850 139.519 1.00 91.53  ? 317 ARG A O   1 
ATOM   5944 C  CB  . ARG B 2 326 ? 166.125 151.140 137.008 1.00 86.90  ? 317 ARG A CB  1 
ATOM   5945 C  CG  . ARG B 2 326 ? 166.113 150.588 135.603 1.00 90.21  ? 317 ARG A CG  1 
ATOM   5946 C  CD  . ARG B 2 326 ? 165.226 149.361 135.503 1.00 91.55  ? 317 ARG A CD  1 
ATOM   5947 N  NE  . ARG B 2 326 ? 165.495 148.405 136.570 1.00 98.91  ? 317 ARG A NE  1 
ATOM   5948 C  CZ  . ARG B 2 326 ? 166.278 147.342 136.446 1.00 100.39 ? 317 ARG A CZ  1 
ATOM   5949 N  NH1 . ARG B 2 326 ? 166.891 147.064 135.308 1.00 100.27 ? 317 ARG A NH1 1 
ATOM   5950 N  NH2 . ARG B 2 326 ? 166.448 146.535 137.490 1.00 96.11  ? 317 ARG A NH2 1 
ATOM   5951 N  N   . HIS B 2 327 ? 168.774 151.991 138.807 1.00 84.67  ? 318 HIS A N   1 
ATOM   5952 C  CA  . HIS B 2 327 ? 169.386 151.971 140.126 1.00 85.09  ? 318 HIS A CA  1 
ATOM   5953 C  C   . HIS B 2 327 ? 170.099 153.269 140.473 1.00 83.72  ? 318 HIS A C   1 
ATOM   5954 O  O   . HIS B 2 327 ? 170.592 153.404 141.597 1.00 86.26  ? 318 HIS A O   1 
ATOM   5955 C  CB  . HIS B 2 327 ? 170.366 150.803 140.224 1.00 88.78  ? 318 HIS A CB  1 
ATOM   5956 C  CG  . HIS B 2 327 ? 169.848 149.534 139.628 1.00 92.58  ? 318 HIS A CG  1 
ATOM   5957 N  ND1 . HIS B 2 327 ? 170.619 148.716 138.831 1.00 99.11  ? 318 HIS A ND1 1 
ATOM   5958 C  CD2 . HIS B 2 327 ? 168.633 148.943 139.710 1.00 92.34  ? 318 HIS A CD2 1 
ATOM   5959 C  CE1 . HIS B 2 327 ? 169.901 147.674 138.450 1.00 100.13 ? 318 HIS A CE1 1 
ATOM   5960 N  NE2 . HIS B 2 327 ? 168.693 147.788 138.970 1.00 97.46  ? 318 HIS A NE2 1 
ATOM   5961 N  N   . LEU B 2 328 ? 170.161 154.223 139.552 1.00 80.48  ? 319 LEU A N   1 
ATOM   5962 C  CA  . LEU B 2 328 ? 170.798 155.505 139.814 1.00 78.81  ? 319 LEU A CA  1 
ATOM   5963 C  C   . LEU B 2 328 ? 169.866 156.493 140.495 1.00 78.33  ? 319 LEU A C   1 
ATOM   5964 O  O   . LEU B 2 328 ? 170.276 157.626 140.760 1.00 77.46  ? 319 LEU A O   1 
ATOM   5965 C  CB  . LEU B 2 328 ? 171.322 156.114 138.512 1.00 74.28  ? 319 LEU A CB  1 
ATOM   5966 C  CG  . LEU B 2 328 ? 172.555 155.455 137.898 1.00 74.72  ? 319 LEU A CG  1 
ATOM   5967 C  CD1 . LEU B 2 328 ? 173.313 156.444 137.036 1.00 73.76  ? 319 LEU A CD1 1 
ATOM   5968 C  CD2 . LEU B 2 328 ? 173.451 154.885 138.978 1.00 80.16  ? 319 LEU A CD2 1 
ATOM   5969 N  N   . GLY B 2 329 ? 168.628 156.099 140.771 1.00 77.73  ? 320 GLY A N   1 
ATOM   5970 C  CA  . GLY B 2 329 ? 167.669 156.995 141.380 1.00 74.14  ? 320 GLY A CA  1 
ATOM   5971 C  C   . GLY B 2 329 ? 166.511 157.287 140.453 1.00 67.70  ? 320 GLY A C   1 
ATOM   5972 O  O   . GLY B 2 329 ? 166.145 156.447 139.628 1.00 71.94  ? 320 GLY A O   1 
ATOM   5973 N  N   . THR B 2 330 ? 165.927 158.471 140.574 1.00 60.28  ? 321 THR A N   1 
ATOM   5974 C  CA  . THR B 2 330 ? 164.837 158.892 139.712 1.00 57.69  ? 321 THR A CA  1 
ATOM   5975 C  C   . THR B 2 330 ? 165.340 159.951 138.748 1.00 57.08  ? 321 THR A C   1 
ATOM   5976 O  O   . THR B 2 330 ? 166.093 160.848 139.135 1.00 61.22  ? 321 THR A O   1 
ATOM   5977 C  CB  . THR B 2 330 ? 163.666 159.444 140.519 1.00 63.30  ? 321 THR A CB  1 
ATOM   5978 O  OG1 . THR B 2 330 ? 163.979 160.761 140.981 1.00 60.72  ? 321 THR A OG1 1 
ATOM   5979 C  CG2 . THR B 2 330 ? 163.395 158.563 141.705 1.00 68.02  ? 321 THR A CG2 1 
ATOM   5980 N  N   . PHE B 2 331 ? 164.931 159.838 137.492 1.00 55.13  ? 322 PHE A N   1 
ATOM   5981 C  CA  . PHE B 2 331 ? 165.302 160.786 136.455 1.00 53.55  ? 322 PHE A CA  1 
ATOM   5982 C  C   . PHE B 2 331 ? 164.102 161.657 136.125 1.00 54.40  ? 322 PHE A C   1 
ATOM   5983 O  O   . PHE B 2 331 ? 163.001 161.145 135.907 1.00 62.25  ? 322 PHE A O   1 
ATOM   5984 C  CB  . PHE B 2 331 ? 165.779 160.068 135.196 1.00 61.60  ? 322 PHE A CB  1 
ATOM   5985 C  CG  . PHE B 2 331 ? 167.159 159.505 135.305 1.00 62.29  ? 322 PHE A CG  1 
ATOM   5986 C  CD1 . PHE B 2 331 ? 167.366 158.259 135.856 1.00 64.43  ? 322 PHE A CD1 1 
ATOM   5987 C  CD2 . PHE B 2 331 ? 168.247 160.214 134.846 1.00 60.82  ? 322 PHE A CD2 1 
ATOM   5988 C  CE1 . PHE B 2 331 ? 168.630 157.737 135.953 1.00 65.13  ? 322 PHE A CE1 1 
ATOM   5989 C  CE2 . PHE B 2 331 ? 169.513 159.694 134.943 1.00 61.03  ? 322 PHE A CE2 1 
ATOM   5990 C  CZ  . PHE B 2 331 ? 169.703 158.455 135.496 1.00 62.73  ? 322 PHE A CZ  1 
ATOM   5991 N  N   . LEU B 2 332 ? 164.312 162.963 136.103 1.00 48.42  ? 323 LEU A N   1 
ATOM   5992 C  CA  . LEU B 2 332 ? 163.319 163.910 135.635 1.00 48.54  ? 323 LEU A CA  1 
ATOM   5993 C  C   . LEU B 2 332 ? 163.896 164.674 134.452 1.00 53.32  ? 323 LEU A C   1 
ATOM   5994 O  O   . LEU B 2 332 ? 165.084 164.577 134.148 1.00 58.05  ? 323 LEU A O   1 
ATOM   5995 C  CB  . LEU B 2 332 ? 162.895 164.868 136.752 1.00 43.03  ? 323 LEU A CB  1 
ATOM   5996 C  CG  . LEU B 2 332 ? 162.575 164.213 138.092 1.00 43.15  ? 323 LEU A CG  1 
ATOM   5997 C  CD1 . LEU B 2 332 ? 162.600 165.243 139.191 1.00 46.80  ? 323 LEU A CD1 1 
ATOM   5998 C  CD2 . LEU B 2 332 ? 161.232 163.531 138.039 1.00 45.56  ? 323 LEU A CD2 1 
ATOM   5999 N  N   . GLY B 2 333 ? 163.044 165.426 133.773 1.00 53.12  ? 324 GLY A N   1 
ATOM   6000 C  CA  . GLY B 2 333 ? 163.495 166.218 132.647 1.00 52.64  ? 324 GLY A CA  1 
ATOM   6001 C  C   . GLY B 2 333 ? 162.428 167.196 132.224 1.00 57.75  ? 324 GLY A C   1 
ATOM   6002 O  O   . GLY B 2 333 ? 161.237 166.985 132.465 1.00 60.82  ? 324 GLY A O   1 
ATOM   6003 N  N   . ILE B 2 334 ? 162.871 168.271 131.579 1.00 60.55  ? 325 ILE A N   1 
ATOM   6004 C  CA  . ILE B 2 334 ? 161.998 169.357 131.153 1.00 59.63  ? 325 ILE A CA  1 
ATOM   6005 C  C   . ILE B 2 334 ? 161.856 169.287 129.641 1.00 65.21  ? 325 ILE A C   1 
ATOM   6006 O  O   . ILE B 2 334 ? 162.860 169.261 128.921 1.00 73.89  ? 325 ILE A O   1 
ATOM   6007 C  CB  . ILE B 2 334 ? 162.547 170.725 131.585 1.00 58.14  ? 325 ILE A CB  1 
ATOM   6008 C  CG1 . ILE B 2 334 ? 163.315 170.606 132.899 1.00 58.16  ? 325 ILE A CG1 1 
ATOM   6009 C  CG2 . ILE B 2 334 ? 161.418 171.715 131.730 1.00 60.17  ? 325 ILE A CG2 1 
ATOM   6010 C  CD1 . ILE B 2 334 ? 162.462 170.258 134.084 1.00 57.41  ? 325 ILE A CD1 1 
ATOM   6011 N  N   . THR B 2 335 ? 160.619 169.264 129.159 1.00 63.28  ? 326 THR A N   1 
ATOM   6012 C  CA  . THR B 2 335 ? 160.378 169.120 127.730 1.00 68.44  ? 326 THR A CA  1 
ATOM   6013 C  C   . THR B 2 335 ? 158.982 169.630 127.410 1.00 72.05  ? 326 THR A C   1 
ATOM   6014 O  O   . THR B 2 335 ? 158.163 169.857 128.302 1.00 76.03  ? 326 THR A O   1 
ATOM   6015 C  CB  . THR B 2 335 ? 160.548 167.669 127.288 1.00 67.83  ? 326 THR A CB  1 
ATOM   6016 O  OG1 . THR B 2 335 ? 160.689 167.616 125.865 1.00 71.23  ? 326 THR A OG1 1 
ATOM   6017 C  CG2 . THR B 2 335 ? 159.345 166.858 127.701 1.00 68.82  ? 326 THR A CG2 1 
ATOM   6018 N  N   . ILE B 2 336 ? 158.718 169.800 126.115 1.00 69.68  ? 327 ILE A N   1 
ATOM   6019 C  CA  . ILE B 2 336 ? 157.467 170.398 125.665 1.00 71.66  ? 327 ILE A CA  1 
ATOM   6020 C  C   . ILE B 2 336 ? 156.302 169.473 125.993 1.00 75.10  ? 327 ILE A C   1 
ATOM   6021 O  O   . ILE B 2 336 ? 156.422 168.243 125.922 1.00 75.55  ? 327 ILE A O   1 
ATOM   6022 C  CB  . ILE B 2 336 ? 157.540 170.711 124.158 1.00 71.96  ? 327 ILE A CB  1 
ATOM   6023 C  CG1 . ILE B 2 336 ? 158.320 172.003 123.886 1.00 74.89  ? 327 ILE A CG1 1 
ATOM   6024 C  CG2 . ILE B 2 336 ? 156.157 170.826 123.547 1.00 75.15  ? 327 ILE A CG2 1 
ATOM   6025 C  CD1 . ILE B 2 336 ? 159.789 171.978 124.266 1.00 72.03  ? 327 ILE A CD1 1 
ATOM   6026 N  N   . GLN B 2 337 ? 155.169 170.066 126.373 1.00 74.82  ? 328 GLN A N   1 
ATOM   6027 C  CA  . GLN B 2 337 ? 153.985 169.295 126.732 1.00 75.90  ? 328 GLN A CA  1 
ATOM   6028 C  C   . GLN B 2 337 ? 153.552 168.394 125.587 1.00 78.05  ? 328 GLN A C   1 
ATOM   6029 O  O   . GLN B 2 337 ? 153.532 168.804 124.425 1.00 78.80  ? 328 GLN A O   1 
ATOM   6030 C  CB  . GLN B 2 337 ? 152.834 170.232 127.100 1.00 83.67  ? 328 GLN A CB  1 
ATOM   6031 C  CG  . GLN B 2 337 ? 151.657 169.548 127.783 1.00 87.48  ? 328 GLN A CG  1 
ATOM   6032 C  CD  . GLN B 2 337 ? 151.011 170.417 128.850 1.00 87.65  ? 328 GLN A CD  1 
ATOM   6033 O  OE1 . GLN B 2 337 ? 151.116 170.134 130.044 1.00 83.60  ? 328 GLN A OE1 1 
ATOM   6034 N  NE2 . GLN B 2 337 ? 150.348 171.484 128.425 1.00 84.49  ? 328 GLN A NE2 1 
ATOM   6035 N  N   . SER B 2 338 ? 153.192 167.162 125.926 1.00 83.11  ? 329 SER A N   1 
ATOM   6036 C  CA  . SER B 2 338 ? 152.743 166.210 124.922 1.00 85.77  ? 329 SER A CA  1 
ATOM   6037 C  C   . SER B 2 338 ? 151.378 166.614 124.387 1.00 85.32  ? 329 SER A C   1 
ATOM   6038 O  O   . SER B 2 338 ? 150.487 166.992 125.152 1.00 84.82  ? 329 SER A O   1 
ATOM   6039 C  CB  . SER B 2 338 ? 152.681 164.803 125.515 1.00 86.32  ? 329 SER A CB  1 
ATOM   6040 O  OG  . SER B 2 338 ? 151.814 163.971 124.766 1.00 81.26  ? 329 SER A OG  1 
ATOM   6041 N  N   . VAL B 2 339 ? 151.221 166.551 123.064 1.00 83.44  ? 330 VAL A N   1 
ATOM   6042 C  CA  . VAL B 2 339 ? 149.947 166.793 122.408 1.00 81.91  ? 330 VAL A CA  1 
ATOM   6043 C  C   . VAL B 2 339 ? 149.737 165.688 121.383 1.00 80.41  ? 330 VAL A C   1 
ATOM   6044 O  O   . VAL B 2 339 ? 150.539 165.549 120.455 1.00 79.85  ? 330 VAL A O   1 
ATOM   6045 C  CB  . VAL B 2 339 ? 149.885 168.170 121.726 1.00 73.87  ? 330 VAL A CB  1 
ATOM   6046 C  CG1 . VAL B 2 339 ? 148.667 168.252 120.836 1.00 74.73  ? 330 VAL A CG1 1 
ATOM   6047 C  CG2 . VAL B 2 339 ? 149.860 169.270 122.766 1.00 76.30  ? 330 VAL A CG2 1 
ATOM   6048 N  N   . PRO B 2 340 ? 148.692 164.881 121.497 1.00 80.71  ? 331 PRO A N   1 
ATOM   6049 C  CA  . PRO B 2 340 ? 148.519 163.767 120.558 1.00 81.33  ? 331 PRO A CA  1 
ATOM   6050 C  C   . PRO B 2 340 ? 148.090 164.227 119.176 1.00 81.02  ? 331 PRO A C   1 
ATOM   6051 O  O   . PRO B 2 340 ? 146.962 164.692 118.994 1.00 83.08  ? 331 PRO A O   1 
ATOM   6052 C  CB  . PRO B 2 340 ? 147.435 162.914 121.226 1.00 89.61  ? 331 PRO A CB  1 
ATOM   6053 C  CG  . PRO B 2 340 ? 146.662 163.878 122.057 1.00 86.82  ? 331 PRO A CG  1 
ATOM   6054 C  CD  . PRO B 2 340 ? 147.639 164.919 122.525 1.00 81.45  ? 331 PRO A CD  1 
ATOM   6055 N  N   . ILE B 2 341 ? 148.978 164.099 118.198 1.00 77.02  ? 332 ILE A N   1 
ATOM   6056 C  CA  . ILE B 2 341 ? 148.675 164.444 116.813 1.00 71.75  ? 332 ILE A CA  1 
ATOM   6057 C  C   . ILE B 2 341 ? 147.990 163.243 116.172 1.00 73.72  ? 332 ILE A C   1 
ATOM   6058 O  O   . ILE B 2 341 ? 148.601 162.167 116.098 1.00 79.16  ? 332 ILE A O   1 
ATOM   6059 C  CB  . ILE B 2 341 ? 149.939 164.823 116.038 1.00 72.49  ? 332 ILE A CB  1 
ATOM   6060 C  CG1 . ILE B 2 341 ? 150.773 165.813 116.844 1.00 76.80  ? 332 ILE A CG1 1 
ATOM   6061 C  CG2 . ILE B 2 341 ? 149.568 165.402 114.696 1.00 71.79  ? 332 ILE A CG2 1 
ATOM   6062 C  CD1 . ILE B 2 341 ? 151.855 166.481 116.043 1.00 70.20  ? 332 ILE A CD1 1 
ATOM   6063 N  N   . PRO B 2 342 ? 146.752 163.374 115.701 1.00 75.23  ? 333 PRO A N   1 
ATOM   6064 C  CA  . PRO B 2 342 ? 146.050 162.211 115.149 1.00 78.35  ? 333 PRO A CA  1 
ATOM   6065 C  C   . PRO B 2 342 ? 146.676 161.763 113.837 1.00 83.54  ? 333 PRO A C   1 
ATOM   6066 O  O   . PRO B 2 342 ? 146.958 162.578 112.958 1.00 84.28  ? 333 PRO A O   1 
ATOM   6067 C  CB  . PRO B 2 342 ? 144.618 162.720 114.944 1.00 74.78  ? 333 PRO A CB  1 
ATOM   6068 C  CG  . PRO B 2 342 ? 144.531 163.988 115.729 1.00 76.53  ? 333 PRO A CG  1 
ATOM   6069 C  CD  . PRO B 2 342 ? 145.902 164.571 115.711 1.00 76.07  ? 333 PRO A CD  1 
ATOM   6070 N  N   . GLY B 2 343 ? 146.897 160.458 113.717 1.00 85.17  ? 334 GLY A N   1 
ATOM   6071 C  CA  . GLY B 2 343 ? 147.351 159.880 112.473 1.00 86.68  ? 334 GLY A CA  1 
ATOM   6072 C  C   . GLY B 2 343 ? 148.820 160.047 112.168 1.00 90.37  ? 334 GLY A C   1 
ATOM   6073 O  O   . GLY B 2 343 ? 149.245 159.696 111.063 1.00 94.25  ? 334 GLY A O   1 
ATOM   6074 N  N   . PHE B 2 344 ? 149.612 160.581 113.096 1.00 85.83  ? 335 PHE A N   1 
ATOM   6075 C  CA  . PHE B 2 344 ? 151.035 160.730 112.817 1.00 86.75  ? 335 PHE A CA  1 
ATOM   6076 C  C   . PHE B 2 344 ? 151.780 159.409 112.945 1.00 92.93  ? 335 PHE A C   1 
ATOM   6077 O  O   . PHE B 2 344 ? 152.709 159.145 112.176 1.00 97.54  ? 335 PHE A O   1 
ATOM   6078 C  CB  . PHE B 2 344 ? 151.662 161.767 113.741 1.00 85.34  ? 335 PHE A CB  1 
ATOM   6079 C  CG  . PHE B 2 344 ? 153.150 161.853 113.612 1.00 84.18  ? 335 PHE A CG  1 
ATOM   6080 C  CD1 . PHE B 2 344 ? 153.726 162.290 112.439 1.00 78.58  ? 335 PHE A CD1 1 
ATOM   6081 C  CD2 . PHE B 2 344 ? 153.973 161.481 114.652 1.00 88.28  ? 335 PHE A CD2 1 
ATOM   6082 C  CE1 . PHE B 2 344 ? 155.093 162.366 112.310 1.00 76.42  ? 335 PHE A CE1 1 
ATOM   6083 C  CE2 . PHE B 2 344 ? 155.344 161.555 114.526 1.00 85.18  ? 335 PHE A CE2 1 
ATOM   6084 C  CZ  . PHE B 2 344 ? 155.902 161.999 113.353 1.00 77.90  ? 335 PHE A CZ  1 
ATOM   6085 N  N   . SER B 2 345 ? 151.408 158.577 113.920 1.00 89.95  ? 336 SER A N   1 
ATOM   6086 C  CA  . SER B 2 345 ? 152.097 157.302 114.094 1.00 93.05  ? 336 SER A CA  1 
ATOM   6087 C  C   . SER B 2 345 ? 151.872 156.384 112.898 1.00 96.60  ? 336 SER A C   1 
ATOM   6088 O  O   . SER B 2 345 ? 152.814 155.751 112.407 1.00 97.32  ? 336 SER A O   1 
ATOM   6089 C  CB  . SER B 2 345 ? 151.639 156.630 115.386 1.00 98.15  ? 336 SER A CB  1 
ATOM   6090 O  OG  . SER B 2 345 ? 150.415 155.942 115.200 1.00 105.01 ? 336 SER A OG  1 
ATOM   6091 N  N   . GLU B 2 346 ? 150.632 156.307 112.408 1.00 95.24  ? 337 GLU A N   1 
ATOM   6092 C  CA  . GLU B 2 346 ? 150.365 155.510 111.216 1.00 95.32  ? 337 GLU A CA  1 
ATOM   6093 C  C   . GLU B 2 346 ? 151.088 156.079 110.006 1.00 97.94  ? 337 GLU A C   1 
ATOM   6094 O  O   . GLU B 2 346 ? 151.580 155.326 109.160 1.00 102.16 ? 337 GLU A O   1 
ATOM   6095 C  CB  . GLU B 2 346 ? 148.863 155.435 110.948 1.00 96.80  ? 337 GLU A CB  1 
ATOM   6096 C  CG  . GLU B 2 346 ? 148.148 154.282 111.634 1.00 104.38 ? 337 GLU A CG  1 
ATOM   6097 C  CD  . GLU B 2 346 ? 147.799 154.580 113.077 1.00 110.36 ? 337 GLU A CD  1 
ATOM   6098 O  OE1 . GLU B 2 346 ? 147.762 155.773 113.445 1.00 108.46 ? 337 GLU A OE1 1 
ATOM   6099 O  OE2 . GLU B 2 346 ? 147.550 153.623 113.840 1.00 107.19 ? 337 GLU A OE2 1 
ATOM   6100 N  N   . PHE B 2 347 ? 151.152 157.408 109.902 1.00 95.55  ? 338 PHE A N   1 
ATOM   6101 C  CA  . PHE B 2 347 ? 151.861 158.034 108.792 1.00 97.10  ? 338 PHE A CA  1 
ATOM   6102 C  C   . PHE B 2 347 ? 153.342 157.682 108.816 1.00 103.03 ? 338 PHE A C   1 
ATOM   6103 O  O   . PHE B 2 347 ? 153.933 157.376 107.774 1.00 107.43 ? 338 PHE A O   1 
ATOM   6104 C  CB  . PHE B 2 347 ? 151.670 159.549 108.844 1.00 89.05  ? 338 PHE A CB  1 
ATOM   6105 C  CG  . PHE B 2 347 ? 152.587 160.309 107.936 1.00 88.12  ? 338 PHE A CG  1 
ATOM   6106 C  CD1 . PHE B 2 347 ? 152.241 160.539 106.620 1.00 89.45  ? 338 PHE A CD1 1 
ATOM   6107 C  CD2 . PHE B 2 347 ? 153.797 160.795 108.398 1.00 86.73  ? 338 PHE A CD2 1 
ATOM   6108 C  CE1 . PHE B 2 347 ? 153.081 161.238 105.783 1.00 89.84  ? 338 PHE A CE1 1 
ATOM   6109 C  CE2 . PHE B 2 347 ? 154.641 161.488 107.564 1.00 84.86  ? 338 PHE A CE2 1 
ATOM   6110 C  CZ  . PHE B 2 347 ? 154.283 161.713 106.256 1.00 86.63  ? 338 PHE A CZ  1 
ATOM   6111 N  N   . ARG B 2 348 ? 153.963 157.732 109.995 1.00 99.56  ? 339 ARG A N   1 
ATOM   6112 C  CA  . ARG B 2 348 ? 155.368 157.360 110.104 1.00 99.03  ? 339 ARG A CA  1 
ATOM   6113 C  C   . ARG B 2 348 ? 155.574 155.886 109.785 1.00 103.78 ? 339 ARG A C   1 
ATOM   6114 O  O   . ARG B 2 348 ? 156.526 155.524 109.085 1.00 103.35 ? 339 ARG A O   1 
ATOM   6115 C  CB  . ARG B 2 348 ? 155.886 157.683 111.504 1.00 94.08  ? 339 ARG A CB  1 
ATOM   6116 C  CG  . ARG B 2 348 ? 157.346 157.334 111.724 1.00 92.02  ? 339 ARG A CG  1 
ATOM   6117 C  CD  . ARG B 2 348 ? 157.557 156.698 113.086 1.00 93.18  ? 339 ARG A CD  1 
ATOM   6118 N  NE  . ARG B 2 348 ? 157.468 157.673 114.165 1.00 94.82  ? 339 ARG A NE  1 
ATOM   6119 C  CZ  . ARG B 2 348 ? 156.439 157.780 114.994 1.00 96.40  ? 339 ARG A CZ  1 
ATOM   6120 N  NH1 . ARG B 2 348 ? 155.385 156.988 114.892 1.00 96.61  ? 339 ARG A NH1 1 
ATOM   6121 N  NH2 . ARG B 2 348 ? 156.468 158.706 115.948 1.00 90.38  ? 339 ARG A NH2 1 
ATOM   6122 N  N   . GLU B 2 349 ? 154.689 155.019 110.284 1.00 104.45 ? 340 GLU A N   1 
ATOM   6123 C  CA  . GLU B 2 349 ? 154.856 153.586 110.065 1.00 106.61 ? 340 GLU A CA  1 
ATOM   6124 C  C   . GLU B 2 349 ? 154.673 153.219 108.598 1.00 109.97 ? 340 GLU A C   1 
ATOM   6125 O  O   . GLU B 2 349 ? 155.354 152.322 108.089 1.00 111.82 ? 340 GLU A O   1 
ATOM   6126 C  CB  . GLU B 2 349 ? 153.877 152.803 110.940 1.00 111.48 ? 340 GLU A CB  1 
ATOM   6127 C  CG  . GLU B 2 349 ? 154.235 152.805 112.416 1.00 114.01 ? 340 GLU A CG  1 
ATOM   6128 C  CD  . GLU B 2 349 ? 153.457 151.775 113.213 1.00 115.11 ? 340 GLU A CD  1 
ATOM   6129 O  OE1 . GLU B 2 349 ? 152.418 151.294 112.716 1.00 115.58 ? 340 GLU A OE1 1 
ATOM   6130 O  OE2 . GLU B 2 349 ? 153.889 151.446 114.338 1.00 110.38 ? 340 GLU A OE2 1 
ATOM   6131 N  N   . TRP B 2 350 ? 153.752 153.893 107.905 1.00 111.94 ? 341 TRP A N   1 
ATOM   6132 C  CA  . TRP B 2 350 ? 153.490 153.568 106.506 1.00 118.08 ? 341 TRP A CA  1 
ATOM   6133 C  C   . TRP B 2 350 ? 154.700 153.863 105.628 1.00 120.92 ? 341 TRP A C   1 
ATOM   6134 O  O   . TRP B 2 350 ? 154.992 153.110 104.692 1.00 119.74 ? 341 TRP A O   1 
ATOM   6135 C  CB  . TRP B 2 350 ? 152.270 154.340 106.006 1.00 115.38 ? 341 TRP A CB  1 
ATOM   6136 C  CG  . TRP B 2 350 ? 151.885 153.996 104.601 1.00 120.80 ? 341 TRP A CG  1 
ATOM   6137 C  CD1 . TRP B 2 350 ? 152.158 154.717 103.475 1.00 120.62 ? 341 TRP A CD1 1 
ATOM   6138 C  CD2 . TRP B 2 350 ? 151.154 152.842 104.171 1.00 123.91 ? 341 TRP A CD2 1 
ATOM   6139 N  NE1 . TRP B 2 350 ? 151.643 154.082 102.371 1.00 122.49 ? 341 TRP A NE1 1 
ATOM   6140 C  CE2 . TRP B 2 350 ? 151.021 152.929 102.772 1.00 124.66 ? 341 TRP A CE2 1 
ATOM   6141 C  CE3 . TRP B 2 350 ? 150.599 151.743 104.834 1.00 121.03 ? 341 TRP A CE3 1 
ATOM   6142 C  CZ2 . TRP B 2 350 ? 150.357 151.960 102.025 1.00 123.29 ? 341 TRP A CZ2 1 
ATOM   6143 C  CZ3 . TRP B 2 350 ? 149.940 150.784 104.091 1.00 118.21 ? 341 TRP A CZ3 1 
ATOM   6144 C  CH2 . TRP B 2 350 ? 149.824 150.898 102.702 1.00 120.28 ? 341 TRP A CH2 1 
ATOM   6145 N  N   . GLY B 2 351 ? 155.404 154.955 105.904 1.00 118.32 ? 342 GLY A N   1 
ATOM   6146 C  CA  . GLY B 2 351 ? 156.577 155.317 105.131 1.00 116.28 ? 342 GLY A CA  1 
ATOM   6147 C  C   . GLY B 2 351 ? 157.727 154.342 105.288 1.00 114.15 ? 342 GLY A C   1 
ATOM   6148 O  O   . GLY B 2 351 ? 157.849 153.383 104.526 1.00 109.80 ? 342 GLY A O   1 
ATOM   6149 N  N   . THR B 2 367 ? 170.191 167.063 95.622  1.00 96.55  ? 358 THR A N   1 
ATOM   6150 C  CA  . THR B 2 367 ? 171.561 167.539 95.483  1.00 101.53 ? 358 THR A CA  1 
ATOM   6151 C  C   . THR B 2 367 ? 172.490 166.827 96.464  1.00 102.61 ? 358 THR A C   1 
ATOM   6152 O  O   . THR B 2 367 ? 172.506 165.599 96.528  1.00 100.86 ? 358 THR A O   1 
ATOM   6153 C  CB  . THR B 2 367 ? 171.649 169.063 95.691  1.00 97.97  ? 358 THR A CB  1 
ATOM   6154 O  OG1 . THR B 2 367 ? 171.175 169.404 96.999  1.00 92.27  ? 358 THR A OG1 1 
ATOM   6155 C  CG2 . THR B 2 367 ? 170.808 169.785 94.650  1.00 95.80  ? 358 THR A CG2 1 
ATOM   6156 N  N   . CYS B 2 368 ? 173.260 167.597 97.226  1.00 100.53 ? 359 CYS A N   1 
ATOM   6157 C  CA  . CYS B 2 368 ? 174.236 167.057 98.158  1.00 100.15 ? 359 CYS A CA  1 
ATOM   6158 C  C   . CYS B 2 368 ? 173.720 167.161 99.587  1.00 93.90  ? 359 CYS A C   1 
ATOM   6159 O  O   . CYS B 2 368 ? 172.974 168.082 99.928  1.00 90.85  ? 359 CYS A O   1 
ATOM   6160 C  CB  . CYS B 2 368 ? 175.573 167.790 98.035  1.00 104.37 ? 359 CYS A CB  1 
ATOM   6161 S  SG  . CYS B 2 368 ? 176.750 166.999 96.920  1.00 120.52 ? 359 CYS A SG  1 
ATOM   6162 N  N   . ASN B 2 369 ? 174.137 166.206 100.417 1.00 92.03  ? 360 ASN A N   1 
ATOM   6163 C  CA  . ASN B 2 369 ? 173.737 166.142 101.822 1.00 87.10  ? 360 ASN A CA  1 
ATOM   6164 C  C   . ASN B 2 369 ? 172.219 166.106 101.961 1.00 84.37  ? 360 ASN A C   1 
ATOM   6165 O  O   . ASN B 2 369 ? 171.624 166.829 102.760 1.00 86.38  ? 360 ASN A O   1 
ATOM   6166 C  CB  . ASN B 2 369 ? 174.330 167.305 102.613 1.00 85.53  ? 360 ASN A CB  1 
ATOM   6167 C  CG  . ASN B 2 369 ? 175.065 166.847 103.846 1.00 93.61  ? 360 ASN A CG  1 
ATOM   6168 O  OD1 . ASN B 2 369 ? 175.304 165.654 104.029 1.00 98.52  ? 360 ASN A OD1 1 
ATOM   6169 N  ND2 . ASN B 2 369 ? 175.432 167.791 104.702 1.00 96.47  ? 360 ASN A ND2 1 
ATOM   6170 N  N   . GLN B 2 370 ? 171.587 165.245 101.166 1.00 82.44  ? 361 GLN A N   1 
ATOM   6171 C  CA  . GLN B 2 370 ? 170.131 165.194 101.142 1.00 80.77  ? 361 GLN A CA  1 
ATOM   6172 C  C   . GLN B 2 370 ? 169.595 163.770 101.067 1.00 88.34  ? 361 GLN A C   1 
ATOM   6173 O  O   . GLN B 2 370 ? 168.454 163.576 100.639 1.00 93.60  ? 361 GLN A O   1 
ATOM   6174 C  CB  . GLN B 2 370 ? 169.593 165.998 99.961  1.00 84.27  ? 361 GLN A CB  1 
ATOM   6175 C  CG  . GLN B 2 370 ? 168.305 166.731 100.236 1.00 80.04  ? 361 GLN A CG  1 
ATOM   6176 C  CD  . GLN B 2 370 ? 168.032 167.809 99.216  1.00 81.64  ? 361 GLN A CD  1 
ATOM   6177 O  OE1 . GLN B 2 370 ? 168.953 168.347 98.607  1.00 88.24  ? 361 GLN A OE1 1 
ATOM   6178 N  NE2 . GLN B 2 370 ? 166.763 168.124 99.013  1.00 78.74  ? 361 GLN A NE2 1 
ATOM   6179 N  N   . GLU B 2 371 ? 170.382 162.769 101.454 1.00 93.19  ? 362 GLU A N   1 
ATOM   6180 C  CA  . GLU B 2 371 ? 169.931 161.388 101.352 1.00 99.03  ? 362 GLU A CA  1 
ATOM   6181 C  C   . GLU B 2 371 ? 170.531 160.567 102.480 1.00 104.24 ? 362 GLU A C   1 
ATOM   6182 O  O   . GLU B 2 371 ? 171.750 160.560 102.663 1.00 108.61 ? 362 GLU A O   1 
ATOM   6183 C  CB  . GLU B 2 371 ? 170.317 160.782 99.999  1.00 100.96 ? 362 GLU A CB  1 
ATOM   6184 C  CG  . GLU B 2 371 ? 169.345 161.098 98.877  1.00 105.75 ? 362 GLU A CG  1 
ATOM   6185 C  CD  . GLU B 2 371 ? 168.199 160.113 98.799  1.00 109.89 ? 362 GLU A CD  1 
ATOM   6186 O  OE1 . GLU B 2 371 ? 168.172 159.164 99.609  1.00 110.31 ? 362 GLU A OE1 1 
ATOM   6187 O  OE2 . GLU B 2 371 ? 167.323 160.290 97.927  1.00 109.01 ? 362 GLU A OE2 1 
ATOM   6188 N  N   . CYS B 2 372 ? 169.672 159.876 103.224 1.00 106.19 ? 363 CYS A N   1 
ATOM   6189 C  CA  . CYS B 2 372 ? 170.098 158.909 104.222 1.00 113.58 ? 363 CYS A CA  1 
ATOM   6190 C  C   . CYS B 2 372 ? 169.325 157.615 104.013 1.00 119.61 ? 363 CYS A C   1 
ATOM   6191 O  O   . CYS B 2 372 ? 168.120 157.636 103.748 1.00 119.12 ? 363 CYS A O   1 
ATOM   6192 C  CB  . CYS B 2 372 ? 169.893 159.439 105.647 1.00 111.06 ? 363 CYS A CB  1 
ATOM   6193 S  SG  . CYS B 2 372 ? 168.220 159.283 106.298 1.00 120.91 ? 363 CYS A SG  1 
ATOM   6194 N  N   . ASP B 2 373 ? 170.028 156.492 104.118 1.00 122.74 ? 364 ASP A N   1 
ATOM   6195 C  CA  . ASP B 2 373 ? 169.452 155.176 103.870 1.00 123.49 ? 364 ASP A CA  1 
ATOM   6196 C  C   . ASP B 2 373 ? 169.232 154.370 105.136 1.00 119.84 ? 364 ASP A C   1 
ATOM   6197 O  O   . ASP B 2 373 ? 168.199 153.713 105.273 1.00 118.31 ? 364 ASP A O   1 
ATOM   6198 C  CB  . ASP B 2 373 ? 170.353 154.375 102.921 1.00 129.01 ? 364 ASP A CB  1 
ATOM   6199 C  CG  . ASP B 2 373 ? 171.069 155.253 101.911 1.00 132.30 ? 364 ASP A CG  1 
ATOM   6200 O  OD1 . ASP B 2 373 ? 170.386 155.921 101.109 1.00 129.87 ? 364 ASP A OD1 1 
ATOM   6201 O  OD2 . ASP B 2 373 ? 172.318 155.274 101.921 1.00 132.72 ? 364 ASP A OD2 1 
ATOM   6202 N  N   . ASN B 2 374 ? 170.178 154.411 106.074 1.00 118.23 ? 365 ASN A N   1 
ATOM   6203 C  CA  . ASN B 2 374 ? 170.061 153.637 107.301 1.00 117.02 ? 365 ASN A CA  1 
ATOM   6204 C  C   . ASN B 2 374 ? 168.999 154.185 108.239 1.00 118.19 ? 365 ASN A C   1 
ATOM   6205 O  O   . ASN B 2 374 ? 168.700 153.538 109.246 1.00 121.25 ? 365 ASN A O   1 
ATOM   6206 C  CB  . ASN B 2 374 ? 171.403 153.597 108.029 1.00 118.45 ? 365 ASN A CB  1 
ATOM   6207 C  CG  . ASN B 2 374 ? 172.580 153.671 107.082 1.00 125.05 ? 365 ASN A CG  1 
ATOM   6208 O  OD1 . ASN B 2 374 ? 172.647 152.935 106.098 1.00 125.59 ? 365 ASN A OD1 1 
ATOM   6209 N  ND2 . ASN B 2 374 ? 173.517 154.565 107.373 1.00 125.89 ? 365 ASN A ND2 1 
ATOM   6210 N  N   . CYS B 2 375 ? 168.435 155.356 107.940 1.00 118.18 ? 366 CYS A N   1 
ATOM   6211 C  CA  . CYS B 2 375 ? 167.485 155.977 108.855 1.00 117.90 ? 366 CYS A CA  1 
ATOM   6212 C  C   . CYS B 2 375 ? 166.247 155.113 109.048 1.00 116.60 ? 366 CYS A C   1 
ATOM   6213 O  O   . CYS B 2 375 ? 165.747 154.981 110.170 1.00 112.34 ? 366 CYS A O   1 
ATOM   6214 C  CB  . CYS B 2 375 ? 167.099 157.362 108.344 1.00 115.83 ? 366 CYS A CB  1 
ATOM   6215 S  SG  . CYS B 2 375 ? 168.487 158.495 108.149 1.00 125.05 ? 366 CYS A SG  1 
ATOM   6216 N  N   . LEU B 2 376 ? 165.735 154.517 107.969 1.00 116.70 ? 367 LEU A N   1 
ATOM   6217 C  CA  . LEU B 2 376 ? 164.542 153.685 108.088 1.00 113.86 ? 367 LEU A CA  1 
ATOM   6218 C  C   . LEU B 2 376 ? 164.798 152.468 108.967 1.00 113.32 ? 367 LEU A C   1 
ATOM   6219 O  O   . LEU B 2 376 ? 164.023 152.177 109.885 1.00 112.22 ? 367 LEU A O   1 
ATOM   6220 C  CB  . LEU B 2 376 ? 164.059 153.256 106.704 1.00 112.95 ? 367 LEU A CB  1 
ATOM   6221 C  CG  . LEU B 2 376 ? 162.555 153.000 106.596 1.00 113.38 ? 367 LEU A CG  1 
ATOM   6222 C  CD1 . LEU B 2 376 ? 161.773 154.034 107.384 1.00 107.82 ? 367 LEU A CD1 1 
ATOM   6223 C  CD2 . LEU B 2 376 ? 162.118 152.991 105.141 1.00 116.20 ? 367 LEU A CD2 1 
ATOM   6224 N  N   . ASN B 2 377 ? 165.883 151.743 108.702 1.00 114.81 ? 368 ASN A N   1 
ATOM   6225 C  CA  . ASN B 2 377 ? 166.145 150.537 109.476 1.00 115.79 ? 368 ASN A CA  1 
ATOM   6226 C  C   . ASN B 2 377 ? 166.534 150.865 110.910 1.00 112.70 ? 368 ASN A C   1 
ATOM   6227 O  O   . ASN B 2 377 ? 166.356 150.032 111.804 1.00 110.55 ? 368 ASN A O   1 
ATOM   6228 C  CB  . ASN B 2 377 ? 167.228 149.703 108.797 1.00 123.45 ? 368 ASN A CB  1 
ATOM   6229 C  CG  . ASN B 2 377 ? 166.649 148.635 107.894 1.00 129.47 ? 368 ASN A CG  1 
ATOM   6230 O  OD1 . ASN B 2 377 ? 165.538 148.779 107.384 1.00 129.16 ? 368 ASN A OD1 1 
ATOM   6231 N  ND2 . ASN B 2 377 ? 167.393 147.555 107.692 1.00 133.01 ? 368 ASN A ND2 1 
ATOM   6232 N  N   . ALA B 2 378 ? 167.072 152.062 111.150 1.00 114.60 ? 369 ALA A N   1 
ATOM   6233 C  CA  . ALA B 2 378 ? 167.379 152.468 112.517 1.00 111.71 ? 369 ALA A CA  1 
ATOM   6234 C  C   . ALA B 2 378 ? 166.118 152.850 113.277 1.00 110.62 ? 369 ALA A C   1 
ATOM   6235 O  O   . ALA B 2 378 ? 165.973 152.512 114.457 1.00 111.00 ? 369 ALA A O   1 
ATOM   6236 C  CB  . ALA B 2 378 ? 168.369 153.629 112.514 1.00 110.29 ? 369 ALA A CB  1 
ATOM   6237 N  N   . THR B 2 379 ? 165.197 153.557 112.624 1.00 106.60 ? 370 THR A N   1 
ATOM   6238 C  CA  . THR B 2 379 ? 163.977 153.993 113.288 1.00 104.83 ? 370 THR A CA  1 
ATOM   6239 C  C   . THR B 2 379 ? 162.924 152.899 113.370 1.00 104.58 ? 370 THR A C   1 
ATOM   6240 O  O   . THR B 2 379 ? 161.950 153.056 114.112 1.00 100.54 ? 370 THR A O   1 
ATOM   6241 C  CB  . THR B 2 379 ? 163.391 155.213 112.575 1.00 101.00 ? 370 THR A CB  1 
ATOM   6242 O  OG1 . THR B 2 379 ? 162.405 155.827 113.411 1.00 99.32  ? 370 THR A OG1 1 
ATOM   6243 C  CG2 . THR B 2 379 ? 162.742 154.804 111.271 1.00 103.99 ? 370 THR A CG2 1 
ATOM   6244 N  N   . LEU B 2 380 ? 163.087 151.803 112.626 1.00 107.91 ? 371 LEU A N   1 
ATOM   6245 C  CA  . LEU B 2 380 ? 162.150 150.693 112.753 1.00 108.07 ? 371 LEU A CA  1 
ATOM   6246 C  C   . LEU B 2 380 ? 162.200 150.089 114.151 1.00 106.32 ? 371 LEU A C   1 
ATOM   6247 O  O   . LEU B 2 380 ? 161.160 149.752 114.727 1.00 103.52 ? 371 LEU A O   1 
ATOM   6248 C  CB  . LEU B 2 380 ? 162.448 149.630 111.696 1.00 108.84 ? 371 LEU A CB  1 
ATOM   6249 C  CG  . LEU B 2 380 ? 161.895 149.904 110.295 1.00 113.02 ? 371 LEU A CG  1 
ATOM   6250 C  CD1 . LEU B 2 380 ? 162.553 148.997 109.267 1.00 111.86 ? 371 LEU A CD1 1 
ATOM   6251 C  CD2 . LEU B 2 380 ? 160.381 149.757 110.265 1.00 111.56 ? 371 LEU A CD2 1 
ATOM   6252 N  N   . SER B 2 381 ? 163.402 149.944 114.712 1.00 108.58 ? 372 SER A N   1 
ATOM   6253 C  CA  . SER B 2 381 ? 163.540 149.372 116.045 1.00 106.39 ? 372 SER A CA  1 
ATOM   6254 C  C   . SER B 2 381 ? 163.004 150.292 117.132 1.00 109.56 ? 372 SER A C   1 
ATOM   6255 O  O   . SER B 2 381 ? 162.705 149.819 118.234 1.00 109.95 ? 372 SER A O   1 
ATOM   6256 C  CB  . SER B 2 381 ? 165.005 149.042 116.327 1.00 99.15  ? 372 SER A CB  1 
ATOM   6257 O  OG  . SER B 2 381 ? 165.770 150.221 116.504 1.00 96.04  ? 372 SER A OG  1 
ATOM   6258 N  N   . PHE B 2 382 ? 162.878 151.587 116.853 1.00 107.80 ? 373 PHE A N   1 
ATOM   6259 C  CA  . PHE B 2 382 ? 162.374 152.552 117.819 1.00 103.66 ? 373 PHE A CA  1 
ATOM   6260 C  C   . PHE B 2 382 ? 160.915 152.904 117.586 1.00 102.96 ? 373 PHE A C   1 
ATOM   6261 O  O   . PHE B 2 382 ? 160.430 153.886 118.151 1.00 102.82 ? 373 PHE A O   1 
ATOM   6262 C  CB  . PHE B 2 382 ? 163.220 153.823 117.788 1.00 99.62  ? 373 PHE A CB  1 
ATOM   6263 C  CG  . PHE B 2 382 ? 164.408 153.779 118.696 1.00 99.04  ? 373 PHE A CG  1 
ATOM   6264 C  CD1 . PHE B 2 382 ? 164.431 152.931 119.786 1.00 103.29 ? 373 PHE A CD1 1 
ATOM   6265 C  CD2 . PHE B 2 382 ? 165.504 154.583 118.460 1.00 96.78  ? 373 PHE A CD2 1 
ATOM   6266 C  CE1 . PHE B 2 382 ? 165.524 152.888 120.625 1.00 104.35 ? 373 PHE A CE1 1 
ATOM   6267 C  CE2 . PHE B 2 382 ? 166.599 154.543 119.294 1.00 98.57  ? 373 PHE A CE2 1 
ATOM   6268 C  CZ  . PHE B 2 382 ? 166.610 153.694 120.378 1.00 98.77  ? 373 PHE A CZ  1 
ATOM   6269 N  N   . ASN B 2 383 ? 160.208 152.133 116.759 1.00 104.80 ? 374 ASN A N   1 
ATOM   6270 C  CA  . ASN B 2 383 ? 158.827 152.473 116.434 1.00 107.70 ? 374 ASN A CA  1 
ATOM   6271 C  C   . ASN B 2 383 ? 157.933 152.439 117.665 1.00 104.52 ? 374 ASN A C   1 
ATOM   6272 O  O   . ASN B 2 383 ? 157.116 153.342 117.869 1.00 103.23 ? 374 ASN A O   1 
ATOM   6273 C  CB  . ASN B 2 383 ? 158.294 151.523 115.365 1.00 110.88 ? 374 ASN A CB  1 
ATOM   6274 C  CG  . ASN B 2 383 ? 157.348 152.204 114.403 1.00 113.60 ? 374 ASN A CG  1 
ATOM   6275 O  OD1 . ASN B 2 383 ? 156.936 153.343 114.620 1.00 111.81 ? 374 ASN A OD1 1 
ATOM   6276 N  ND2 . ASN B 2 383 ? 156.996 151.508 113.331 1.00 113.67 ? 374 ASN A ND2 1 
ATOM   6277 N  N   . THR B 2 384 ? 158.070 151.406 118.498 1.00 100.81 ? 375 THR A N   1 
ATOM   6278 C  CA  . THR B 2 384 ? 157.150 151.240 119.619 1.00 100.72 ? 375 THR A CA  1 
ATOM   6279 C  C   . THR B 2 384 ? 157.367 152.311 120.680 1.00 100.11 ? 375 THR A C   1 
ATOM   6280 O  O   . THR B 2 384 ? 156.408 152.927 121.159 1.00 96.98  ? 375 THR A O   1 
ATOM   6281 C  CB  . THR B 2 384 ? 157.309 149.848 120.222 1.00 102.03 ? 375 THR A CB  1 
ATOM   6282 O  OG1 . THR B 2 384 ? 158.686 149.458 120.162 1.00 103.24 ? 375 THR A OG1 1 
ATOM   6283 C  CG2 . THR B 2 384 ? 156.469 148.844 119.453 1.00 101.02 ? 375 THR A CG2 1 
ATOM   6284 N  N   . ILE B 2 385 ? 158.623 152.546 121.062 1.00 100.98 ? 376 ILE A N   1 
ATOM   6285 C  CA  . ILE B 2 385 ? 158.909 153.553 122.078 1.00 96.13  ? 376 ILE A CA  1 
ATOM   6286 C  C   . ILE B 2 385 ? 158.551 154.944 121.571 1.00 96.05  ? 376 ILE A C   1 
ATOM   6287 O  O   . ILE B 2 385 ? 157.995 155.762 122.312 1.00 97.57  ? 376 ILE A O   1 
ATOM   6288 C  CB  . ILE B 2 385 ? 160.380 153.465 122.518 1.00 95.71  ? 376 ILE A CB  1 
ATOM   6289 C  CG1 . ILE B 2 385 ? 160.760 154.674 123.369 1.00 91.98  ? 376 ILE A CG1 1 
ATOM   6290 C  CG2 . ILE B 2 385 ? 161.290 153.355 121.315 1.00 98.39  ? 376 ILE A CG2 1 
ATOM   6291 C  CD1 . ILE B 2 385 ? 162.188 154.644 123.849 1.00 93.84  ? 376 ILE A CD1 1 
ATOM   6292 N  N   . LEU B 2 386 ? 158.858 155.236 120.305 1.00 96.31  ? 377 LEU A N   1 
ATOM   6293 C  CA  . LEU B 2 386 ? 158.474 156.523 119.734 1.00 96.13  ? 377 LEU A CA  1 
ATOM   6294 C  C   . LEU B 2 386 ? 156.961 156.675 119.697 1.00 97.01  ? 377 LEU A C   1 
ATOM   6295 O  O   . LEU B 2 386 ? 156.431 157.758 119.967 1.00 95.53  ? 377 LEU A O   1 
ATOM   6296 C  CB  . LEU B 2 386 ? 159.062 156.679 118.332 1.00 94.86  ? 377 LEU A CB  1 
ATOM   6297 C  CG  . LEU B 2 386 ? 160.501 157.184 118.231 1.00 91.50  ? 377 LEU A CG  1 
ATOM   6298 C  CD1 . LEU B 2 386 ? 160.974 157.157 116.794 1.00 86.56  ? 377 LEU A CD1 1 
ATOM   6299 C  CD2 . LEU B 2 386 ? 160.621 158.580 118.799 1.00 91.83  ? 377 LEU A CD2 1 
ATOM   6300 N  N   . ARG B 2 387 ? 156.248 155.601 119.355 1.00 97.58  ? 378 ARG A N   1 
ATOM   6301 C  CA  . ARG B 2 387 ? 154.792 155.669 119.305 1.00 97.03  ? 378 ARG A CA  1 
ATOM   6302 C  C   . ARG B 2 387 ? 154.204 155.919 120.686 1.00 97.66  ? 378 ARG A C   1 
ATOM   6303 O  O   . ARG B 2 387 ? 153.277 156.722 120.839 1.00 94.69  ? 378 ARG A O   1 
ATOM   6304 C  CB  . ARG B 2 387 ? 154.228 154.381 118.711 1.00 94.46  ? 378 ARG A CB  1 
ATOM   6305 C  CG  . ARG B 2 387 ? 152.715 154.318 118.682 1.00 93.87  ? 378 ARG A CG  1 
ATOM   6306 C  CD  . ARG B 2 387 ? 152.236 152.879 118.663 1.00 100.51 ? 378 ARG A CD  1 
ATOM   6307 N  NE  . ARG B 2 387 ? 151.985 152.396 117.311 1.00 105.08 ? 378 ARG A NE  1 
ATOM   6308 C  CZ  . ARG B 2 387 ? 150.922 152.713 116.583 1.00 104.19 ? 378 ARG A CZ  1 
ATOM   6309 N  NH1 . ARG B 2 387 ? 149.986 153.526 117.044 1.00 102.86 ? 378 ARG A NH1 1 
ATOM   6310 N  NH2 . ARG B 2 387 ? 150.795 152.199 115.364 1.00 100.83 ? 378 ARG A NH2 1 
ATOM   6311 N  N   . LEU B 2 388 ? 154.730 155.241 121.706 1.00 98.35  ? 379 LEU A N   1 
ATOM   6312 C  CA  . LEU B 2 388 ? 154.175 155.374 123.047 1.00 96.47  ? 379 LEU A CA  1 
ATOM   6313 C  C   . LEU B 2 388 ? 154.568 156.685 123.710 1.00 94.02  ? 379 LEU A C   1 
ATOM   6314 O  O   . LEU B 2 388 ? 153.802 157.216 124.520 1.00 90.48  ? 379 LEU A O   1 
ATOM   6315 C  CB  . LEU B 2 388 ? 154.618 154.201 123.919 1.00 93.87  ? 379 LEU A CB  1 
ATOM   6316 C  CG  . LEU B 2 388 ? 154.032 152.845 123.542 1.00 92.88  ? 379 LEU A CG  1 
ATOM   6317 C  CD1 . LEU B 2 388 ? 155.017 151.744 123.875 1.00 96.87  ? 379 LEU A CD1 1 
ATOM   6318 C  CD2 . LEU B 2 388 ? 152.710 152.623 124.247 1.00 90.81  ? 379 LEU A CD2 1 
ATOM   6319 N  N   . SER B 2 389 ? 155.745 157.222 123.383 1.00 93.45  ? 380 SER A N   1 
ATOM   6320 C  CA  . SER B 2 389 ? 156.218 158.435 124.036 1.00 91.54  ? 380 SER A CA  1 
ATOM   6321 C  C   . SER B 2 389 ? 155.417 159.661 123.630 1.00 92.79  ? 380 SER A C   1 
ATOM   6322 O  O   . SER B 2 389 ? 155.576 160.719 124.244 1.00 94.90  ? 380 SER A O   1 
ATOM   6323 C  CB  . SER B 2 389 ? 157.694 158.663 123.723 1.00 90.93  ? 380 SER A CB  1 
ATOM   6324 O  OG  . SER B 2 389 ? 157.846 159.409 122.530 1.00 89.86  ? 380 SER A OG  1 
ATOM   6325 N  N   . GLY B 2 390 ? 154.576 159.550 122.614 1.00 89.04  ? 381 GLY A N   1 
ATOM   6326 C  CA  . GLY B 2 390 ? 153.788 160.677 122.172 1.00 86.87  ? 381 GLY A CA  1 
ATOM   6327 C  C   . GLY B 2 390 ? 154.572 161.586 121.249 1.00 87.14  ? 381 GLY A C   1 
ATOM   6328 O  O   . GLY B 2 390 ? 155.555 161.194 120.613 1.00 88.57  ? 381 GLY A O   1 
ATOM   6329 N  N   . GLU B 2 391 ? 154.121 162.835 121.183 1.00 83.61  ? 382 GLU A N   1 
ATOM   6330 C  CA  . GLU B 2 391 ? 154.714 163.839 120.308 1.00 80.50  ? 382 GLU A CA  1 
ATOM   6331 C  C   . GLU B 2 391 ? 154.931 165.114 121.109 1.00 81.49  ? 382 GLU A C   1 
ATOM   6332 O  O   . GLU B 2 391 ? 153.965 165.753 121.538 1.00 78.32  ? 382 GLU A O   1 
ATOM   6333 C  CB  . GLU B 2 391 ? 153.826 164.092 119.093 1.00 77.36  ? 382 GLU A CB  1 
ATOM   6334 C  CG  . GLU B 2 391 ? 153.782 162.924 118.126 1.00 83.45  ? 382 GLU A CG  1 
ATOM   6335 C  CD  . GLU B 2 391 ? 152.661 161.952 118.429 1.00 88.31  ? 382 GLU A CD  1 
ATOM   6336 O  OE1 . GLU B 2 391 ? 151.917 162.188 119.403 1.00 88.32  ? 382 GLU A OE1 1 
ATOM   6337 O  OE2 . GLU B 2 391 ? 152.523 160.950 117.695 1.00 86.79  ? 382 GLU A OE2 1 
ATOM   6338 N  N   . ARG B 2 392 ? 156.197 165.477 121.313 1.00 79.52  ? 383 ARG A N   1 
ATOM   6339 C  CA  . ARG B 2 392 ? 156.562 166.679 122.048 1.00 73.19  ? 383 ARG A CA  1 
ATOM   6340 C  C   . ARG B 2 392 ? 157.243 167.708 121.155 1.00 71.29  ? 383 ARG A C   1 
ATOM   6341 O  O   . ARG B 2 392 ? 156.764 168.837 121.040 1.00 73.45  ? 383 ARG A O   1 
ATOM   6342 C  CB  . ARG B 2 392 ? 157.468 166.311 123.227 1.00 76.09  ? 383 ARG A CB  1 
ATOM   6343 C  CG  . ARG B 2 392 ? 157.149 164.968 123.851 1.00 76.87  ? 383 ARG A CG  1 
ATOM   6344 C  CD  . ARG B 2 392 ? 157.861 164.797 125.175 1.00 75.07  ? 383 ARG A CD  1 
ATOM   6345 N  NE  . ARG B 2 392 ? 156.964 164.980 126.308 1.00 78.48  ? 383 ARG A NE  1 
ATOM   6346 C  CZ  . ARG B 2 392 ? 156.401 163.989 126.981 1.00 81.57  ? 383 ARG A CZ  1 
ATOM   6347 N  NH1 . ARG B 2 392 ? 156.626 162.725 126.665 1.00 80.19  ? 383 ARG A NH1 1 
ATOM   6348 N  NH2 . ARG B 2 392 ? 155.595 164.272 127.998 1.00 82.67  ? 383 ARG A NH2 1 
ATOM   6349 N  N   . VAL B 2 393 ? 158.354 167.346 120.514 1.00 69.39  ? 384 VAL A N   1 
ATOM   6350 C  CA  . VAL B 2 393 ? 158.983 168.240 119.548 1.00 68.12  ? 384 VAL A CA  1 
ATOM   6351 C  C   . VAL B 2 393 ? 158.372 168.077 118.163 1.00 68.07  ? 384 VAL A C   1 
ATOM   6352 O  O   . VAL B 2 393 ? 158.415 169.018 117.351 1.00 70.03  ? 384 VAL A O   1 
ATOM   6353 C  CB  . VAL B 2 393 ? 160.501 167.999 119.500 1.00 65.31  ? 384 VAL A CB  1 
ATOM   6354 C  CG1 . VAL B 2 393 ? 161.199 169.161 118.829 1.00 70.71  ? 384 VAL A CG1 1 
ATOM   6355 C  CG2 . VAL B 2 393 ? 161.038 167.802 120.896 1.00 61.54  ? 384 VAL A CG2 1 
ATOM   6356 N  N   . VAL B 2 394 ? 157.784 166.916 117.880 1.00 65.17  ? 385 VAL A N   1 
ATOM   6357 C  CA  . VAL B 2 394 ? 157.030 166.740 116.647 1.00 68.19  ? 385 VAL A CA  1 
ATOM   6358 C  C   . VAL B 2 394 ? 155.923 167.777 116.563 1.00 68.33  ? 385 VAL A C   1 
ATOM   6359 O  O   . VAL B 2 394 ? 155.659 168.342 115.495 1.00 71.10  ? 385 VAL A O   1 
ATOM   6360 C  CB  . VAL B 2 394 ? 156.478 165.306 116.570 1.00 69.13  ? 385 VAL A CB  1 
ATOM   6361 C  CG1 . VAL B 2 394 ? 155.231 165.257 115.718 1.00 70.44  ? 385 VAL A CG1 1 
ATOM   6362 C  CG2 . VAL B 2 394 ? 157.537 164.369 116.034 1.00 69.67  ? 385 VAL A CG2 1 
ATOM   6363 N  N   . TYR B 2 395 ? 155.265 168.058 117.688 1.00 64.72  ? 386 TYR A N   1 
ATOM   6364 C  CA  . TYR B 2 395 ? 154.254 169.104 117.689 1.00 60.19  ? 386 TYR A CA  1 
ATOM   6365 C  C   . TYR B 2 395 ? 154.864 170.472 117.440 1.00 58.20  ? 386 TYR A C   1 
ATOM   6366 O  O   . TYR B 2 395 ? 154.217 171.333 116.843 1.00 61.70  ? 386 TYR A O   1 
ATOM   6367 C  CB  . TYR B 2 395 ? 153.486 169.120 119.005 1.00 66.40  ? 386 TYR A CB  1 
ATOM   6368 C  CG  . TYR B 2 395 ? 152.422 170.181 119.020 1.00 66.17  ? 386 TYR A CG  1 
ATOM   6369 C  CD1 . TYR B 2 395 ? 151.241 170.007 118.322 1.00 63.00  ? 386 TYR A CD1 1 
ATOM   6370 C  CD2 . TYR B 2 395 ? 152.609 171.369 119.703 1.00 70.27  ? 386 TYR A CD2 1 
ATOM   6371 C  CE1 . TYR B 2 395 ? 150.269 170.974 118.321 1.00 67.72  ? 386 TYR A CE1 1 
ATOM   6372 C  CE2 . TYR B 2 395 ? 151.642 172.344 119.705 1.00 72.06  ? 386 TYR A CE2 1 
ATOM   6373 C  CZ  . TYR B 2 395 ? 150.475 172.140 119.011 1.00 72.47  ? 386 TYR A CZ  1 
ATOM   6374 O  OH  . TYR B 2 395 ? 149.505 173.108 119.008 1.00 77.82  ? 386 TYR A OH  1 
ATOM   6375 N  N   . SER B 2 396 ? 156.096 170.703 117.896 1.00 57.09  ? 387 SER A N   1 
ATOM   6376 C  CA  . SER B 2 396 ? 156.753 171.970 117.597 1.00 60.12  ? 387 SER A CA  1 
ATOM   6377 C  C   . SER B 2 396 ? 156.960 172.140 116.098 1.00 62.69  ? 387 SER A C   1 
ATOM   6378 O  O   . SER B 2 396 ? 156.701 173.216 115.545 1.00 65.95  ? 387 SER A O   1 
ATOM   6379 C  CB  . SER B 2 396 ? 158.086 172.062 118.335 1.00 64.21  ? 387 SER A CB  1 
ATOM   6380 O  OG  . SER B 2 396 ? 157.891 172.380 119.699 1.00 71.96  ? 387 SER A OG  1 
ATOM   6381 N  N   . VAL B 2 397 ? 157.415 171.084 115.419 1.00 60.58  ? 388 VAL A N   1 
ATOM   6382 C  CA  . VAL B 2 397 ? 157.595 171.168 113.969 1.00 56.79  ? 388 VAL A CA  1 
ATOM   6383 C  C   . VAL B 2 397 ? 156.250 171.335 113.267 1.00 58.54  ? 388 VAL A C   1 
ATOM   6384 O  O   . VAL B 2 397 ? 156.120 172.109 112.307 1.00 62.81  ? 388 VAL A O   1 
ATOM   6385 C  CB  . VAL B 2 397 ? 158.350 169.934 113.453 1.00 56.77  ? 388 VAL A CB  1 
ATOM   6386 C  CG1 . VAL B 2 397 ? 158.781 170.157 112.029 1.00 62.34  ? 388 VAL A CG1 1 
ATOM   6387 C  CG2 . VAL B 2 397 ? 159.547 169.648 114.329 1.00 61.27  ? 388 VAL A CG2 1 
ATOM   6388 N  N   . TYR B 2 398 ? 155.239 170.597 113.725 1.00 55.79  ? 389 TYR A N   1 
ATOM   6389 C  CA  . TYR B 2 398 ? 153.889 170.726 113.188 1.00 53.29  ? 389 TYR A CA  1 
ATOM   6390 C  C   . TYR B 2 398 ? 153.398 172.165 113.289 1.00 57.03  ? 389 TYR A C   1 
ATOM   6391 O  O   . TYR B 2 398 ? 152.889 172.735 112.316 1.00 59.97  ? 389 TYR A O   1 
ATOM   6392 C  CB  . TYR B 2 398 ? 152.970 169.778 113.957 1.00 54.89  ? 389 TYR A CB  1 
ATOM   6393 C  CG  . TYR B 2 398 ? 151.630 169.477 113.341 1.00 54.77  ? 389 TYR A CG  1 
ATOM   6394 C  CD1 . TYR B 2 398 ? 151.522 168.648 112.244 1.00 60.17  ? 389 TYR A CD1 1 
ATOM   6395 C  CD2 . TYR B 2 398 ? 150.467 169.978 113.897 1.00 56.68  ? 389 TYR A CD2 1 
ATOM   6396 C  CE1 . TYR B 2 398 ? 150.297 168.356 111.695 1.00 63.59  ? 389 TYR A CE1 1 
ATOM   6397 C  CE2 . TYR B 2 398 ? 149.240 169.691 113.357 1.00 57.68  ? 389 TYR A CE2 1 
ATOM   6398 C  CZ  . TYR B 2 398 ? 149.158 168.880 112.256 1.00 61.18  ? 389 TYR A CZ  1 
ATOM   6399 O  OH  . TYR B 2 398 ? 147.929 168.590 111.711 1.00 61.41  ? 389 TYR A OH  1 
ATOM   6400 N  N   . SER B 2 399 ? 153.568 172.773 114.461 1.00 56.06  ? 390 SER A N   1 
ATOM   6401 C  CA  . SER B 2 399 ? 153.135 174.146 114.671 1.00 52.80  ? 390 SER A CA  1 
ATOM   6402 C  C   . SER B 2 399 ? 153.919 175.115 113.803 1.00 56.61  ? 390 SER A C   1 
ATOM   6403 O  O   . SER B 2 399 ? 153.353 176.079 113.289 1.00 63.35  ? 390 SER A O   1 
ATOM   6404 C  CB  . SER B 2 399 ? 153.280 174.519 116.141 1.00 57.62  ? 390 SER A CB  1 
ATOM   6405 O  OG  . SER B 2 399 ? 153.577 175.894 116.277 1.00 63.55  ? 390 SER A OG  1 
ATOM   6406 N  N   . ALA B 2 400 ? 155.223 174.893 113.640 1.00 56.70  ? 391 ALA A N   1 
ATOM   6407 C  CA  . ALA B 2 400 ? 156.013 175.780 112.792 1.00 53.43  ? 391 ALA A CA  1 
ATOM   6408 C  C   . ALA B 2 400 ? 155.506 175.762 111.357 1.00 54.01  ? 391 ALA A C   1 
ATOM   6409 O  O   . ALA B 2 400 ? 155.309 176.817 110.735 1.00 57.95  ? 391 ALA A O   1 
ATOM   6410 C  CB  . ALA B 2 400 ? 157.485 175.378 112.842 1.00 54.24  ? 391 ALA A CB  1 
ATOM   6411 N  N   . VAL B 2 401 ? 155.277 174.564 110.815 1.00 52.37  ? 392 VAL A N   1 
ATOM   6412 C  CA  . VAL B 2 401 ? 154.805 174.465 109.437 1.00 51.97  ? 392 VAL A CA  1 
ATOM   6413 C  C   . VAL B 2 401 ? 153.419 175.079 109.300 1.00 60.04  ? 392 VAL A C   1 
ATOM   6414 O  O   . VAL B 2 401 ? 153.127 175.778 108.322 1.00 62.39  ? 392 VAL A O   1 
ATOM   6415 C  CB  . VAL B 2 401 ? 154.827 173.005 108.959 1.00 48.65  ? 392 VAL A CB  1 
ATOM   6416 C  CG1 . VAL B 2 401 ? 154.187 172.895 107.598 1.00 52.69  ? 392 VAL A CG1 1 
ATOM   6417 C  CG2 . VAL B 2 401 ? 156.243 172.505 108.905 1.00 54.15  ? 392 VAL A CG2 1 
ATOM   6418 N  N   . TYR B 2 402 ? 152.541 174.835 110.274 1.00 58.37  ? 393 TYR A N   1 
ATOM   6419 C  CA  . TYR B 2 402 ? 151.201 175.404 110.189 1.00 55.81  ? 393 TYR A CA  1 
ATOM   6420 C  C   . TYR B 2 402 ? 151.231 176.921 110.306 1.00 58.03  ? 393 TYR A C   1 
ATOM   6421 O  O   . TYR B 2 402 ? 150.430 177.610 109.670 1.00 62.01  ? 393 TYR A O   1 
ATOM   6422 C  CB  . TYR B 2 402 ? 150.301 174.794 111.256 1.00 55.57  ? 393 TYR A CB  1 
ATOM   6423 C  CG  . TYR B 2 402 ? 149.257 173.872 110.686 1.00 60.79  ? 393 TYR A CG  1 
ATOM   6424 C  CD1 . TYR B 2 402 ? 149.612 172.651 110.143 1.00 62.49  ? 393 TYR A CD1 1 
ATOM   6425 C  CD2 . TYR B 2 402 ? 147.918 174.216 110.699 1.00 64.34  ? 393 TYR A CD2 1 
ATOM   6426 C  CE1 . TYR B 2 402 ? 148.666 171.803 109.623 1.00 68.24  ? 393 TYR A CE1 1 
ATOM   6427 C  CE2 . TYR B 2 402 ? 146.963 173.372 110.184 1.00 68.59  ? 393 TYR A CE2 1 
ATOM   6428 C  CZ  . TYR B 2 402 ? 147.343 172.166 109.646 1.00 72.02  ? 393 TYR A CZ  1 
ATOM   6429 O  OH  . TYR B 2 402 ? 146.395 171.316 109.128 1.00 77.63  ? 393 TYR A OH  1 
ATOM   6430 N  N   . ALA B 2 403 ? 152.143 177.463 111.112 1.00 57.54  ? 394 ALA A N   1 
ATOM   6431 C  CA  . ALA B 2 403 ? 152.271 178.912 111.207 1.00 58.43  ? 394 ALA A CA  1 
ATOM   6432 C  C   . ALA B 2 403 ? 152.727 179.507 109.886 1.00 58.45  ? 394 ALA A C   1 
ATOM   6433 O  O   . ALA B 2 403 ? 152.196 180.533 109.446 1.00 60.83  ? 394 ALA A O   1 
ATOM   6434 C  CB  . ALA B 2 403 ? 153.242 179.285 112.323 1.00 56.46  ? 394 ALA A CB  1 
ATOM   6435 N  N   . VAL B 2 404 ? 153.705 178.874 109.233 1.00 57.28  ? 395 VAL A N   1 
ATOM   6436 C  CA  . VAL B 2 404 ? 154.121 179.359 107.919 1.00 56.85  ? 395 VAL A CA  1 
ATOM   6437 C  C   . VAL B 2 404 ? 152.960 179.297 106.940 1.00 60.62  ? 395 VAL A C   1 
ATOM   6438 O  O   . VAL B 2 404 ? 152.732 180.231 106.161 1.00 67.74  ? 395 VAL A O   1 
ATOM   6439 C  CB  . VAL B 2 404 ? 155.325 178.565 107.392 1.00 54.08  ? 395 VAL A CB  1 
ATOM   6440 C  CG1 . VAL B 2 404 ? 155.520 178.866 105.934 1.00 48.42  ? 395 VAL A CG1 1 
ATOM   6441 C  CG2 . VAL B 2 404 ? 156.559 178.928 108.147 1.00 56.81  ? 395 VAL A CG2 1 
ATOM   6442 N  N   . ALA B 2 405 ? 152.215 178.193 106.953 1.00 56.07  ? 396 ALA A N   1 
ATOM   6443 C  CA  . ALA B 2 405 ? 151.103 178.053 106.024 1.00 58.16  ? 396 ALA A CA  1 
ATOM   6444 C  C   . ALA B 2 405 ? 150.038 179.109 106.267 1.00 66.33  ? 396 ALA A C   1 
ATOM   6445 O  O   . ALA B 2 405 ? 149.482 179.662 105.317 1.00 73.56  ? 396 ALA A O   1 
ATOM   6446 C  CB  . ALA B 2 405 ? 150.494 176.665 106.133 1.00 63.70  ? 396 ALA A CB  1 
ATOM   6447 N  N   . HIS B 2 406 ? 149.727 179.396 107.529 1.00 66.43  ? 397 HIS A N   1 
ATOM   6448 C  CA  . HIS B 2 406 ? 148.711 180.401 107.814 1.00 68.62  ? 397 HIS A CA  1 
ATOM   6449 C  C   . HIS B 2 406 ? 149.193 181.793 107.430 1.00 68.90  ? 397 HIS A C   1 
ATOM   6450 O  O   . HIS B 2 406 ? 148.407 182.617 106.951 1.00 72.98  ? 397 HIS A O   1 
ATOM   6451 C  CB  . HIS B 2 406 ? 148.315 180.349 109.287 1.00 70.53  ? 397 HIS A CB  1 
ATOM   6452 C  CG  . HIS B 2 406 ? 147.090 179.532 109.551 1.00 76.79  ? 397 HIS A CG  1 
ATOM   6453 N  ND1 . HIS B 2 406 ? 147.145 178.252 110.058 1.00 79.80  ? 397 HIS A ND1 1 
ATOM   6454 C  CD2 . HIS B 2 406 ? 145.777 179.808 109.371 1.00 79.14  ? 397 HIS A CD2 1 
ATOM   6455 C  CE1 . HIS B 2 406 ? 145.920 177.776 110.183 1.00 77.74  ? 397 HIS A CE1 1 
ATOM   6456 N  NE2 . HIS B 2 406 ? 145.071 178.700 109.772 1.00 80.68  ? 397 HIS A NE2 1 
ATOM   6457 N  N   . ALA B 2 407 ? 150.484 182.072 107.623 1.00 67.10  ? 398 ALA A N   1 
ATOM   6458 C  CA  . ALA B 2 407 ? 151.025 183.352 107.181 1.00 69.40  ? 398 ALA A CA  1 
ATOM   6459 C  C   . ALA B 2 407 ? 150.932 183.496 105.669 1.00 68.58  ? 398 ALA A C   1 
ATOM   6460 O  O   . ALA B 2 407 ? 150.566 184.561 105.161 1.00 70.93  ? 398 ALA A O   1 
ATOM   6461 C  CB  . ALA B 2 407 ? 152.471 183.499 107.639 1.00 65.23  ? 398 ALA A CB  1 
ATOM   6462 N  N   . LEU B 2 408 ? 151.262 182.435 104.934 1.00 66.42  ? 399 LEU A N   1 
ATOM   6463 C  CA  . LEU B 2 408 ? 151.133 182.470 103.480 1.00 69.20  ? 399 LEU A CA  1 
ATOM   6464 C  C   . LEU B 2 408 ? 149.675 182.593 103.058 1.00 75.21  ? 399 LEU A C   1 
ATOM   6465 O  O   . LEU B 2 408 ? 149.362 183.258 102.067 1.00 80.51  ? 399 LEU A O   1 
ATOM   6466 C  CB  . LEU B 2 408 ? 151.760 181.219 102.872 1.00 66.29  ? 399 LEU A CB  1 
ATOM   6467 C  CG  . LEU B 2 408 ? 152.083 181.269 101.385 1.00 62.66  ? 399 LEU A CG  1 
ATOM   6468 C  CD1 . LEU B 2 408 ? 152.640 182.624 101.021 1.00 68.82  ? 399 LEU A CD1 1 
ATOM   6469 C  CD2 . LEU B 2 408 ? 153.066 180.173 101.039 1.00 61.61  ? 399 LEU A CD2 1 
ATOM   6470 N  N   . HIS B 2 409 ? 148.776 181.940 103.793 1.00 74.81  ? 400 HIS A N   1 
ATOM   6471 C  CA  . HIS B 2 409 ? 147.351 182.010 103.500 1.00 75.95  ? 400 HIS A CA  1 
ATOM   6472 C  C   . HIS B 2 409 ? 146.825 183.426 103.673 1.00 78.05  ? 400 HIS A C   1 
ATOM   6473 O  O   . HIS B 2 409 ? 146.007 183.897 102.877 1.00 82.45  ? 400 HIS A O   1 
ATOM   6474 C  CB  . HIS B 2 409 ? 146.610 181.037 104.413 1.00 77.62  ? 400 HIS A CB  1 
ATOM   6475 C  CG  . HIS B 2 409 ? 145.135 180.985 104.187 1.00 84.15  ? 400 HIS A CG  1 
ATOM   6476 N  ND1 . HIS B 2 409 ? 144.537 180.015 103.413 1.00 88.52  ? 400 HIS A ND1 1 
ATOM   6477 C  CD2 . HIS B 2 409 ? 144.133 181.767 104.651 1.00 88.25  ? 400 HIS A CD2 1 
ATOM   6478 C  CE1 . HIS B 2 409 ? 143.231 180.209 103.401 1.00 95.03  ? 400 HIS A CE1 1 
ATOM   6479 N  NE2 . HIS B 2 409 ? 142.960 181.265 104.145 1.00 96.44  ? 400 HIS A NE2 1 
ATOM   6480 N  N   . SER B 2 410 ? 147.278 184.118 104.718 1.00 75.22  ? 401 SER A N   1 
ATOM   6481 C  CA  . SER B 2 410 ? 146.863 185.501 104.919 1.00 78.39  ? 401 SER A CA  1 
ATOM   6482 C  C   . SER B 2 410 ? 147.507 186.428 103.898 1.00 79.59  ? 401 SER A C   1 
ATOM   6483 O  O   . SER B 2 410 ? 146.857 187.353 103.399 1.00 83.19  ? 401 SER A O   1 
ATOM   6484 C  CB  . SER B 2 410 ? 147.204 185.956 106.335 1.00 72.70  ? 401 SER A CB  1 
ATOM   6485 O  OG  . SER B 2 410 ? 147.472 187.345 106.361 1.00 66.87  ? 401 SER A OG  1 
ATOM   6486 N  N   . LEU B 2 411 ? 148.785 186.205 103.582 1.00 76.37  ? 402 LEU A N   1 
ATOM   6487 C  CA  . LEU B 2 411 ? 149.475 187.077 102.636 1.00 76.18  ? 402 LEU A CA  1 
ATOM   6488 C  C   . LEU B 2 411 ? 148.849 186.995 101.253 1.00 77.86  ? 402 LEU A C   1 
ATOM   6489 O  O   . LEU B 2 411 ? 148.675 188.017 100.581 1.00 78.79  ? 402 LEU A O   1 
ATOM   6490 C  CB  . LEU B 2 411 ? 150.957 186.718 102.574 1.00 74.01  ? 402 LEU A CB  1 
ATOM   6491 C  CG  . LEU B 2 411 ? 151.849 187.727 101.858 1.00 72.89  ? 402 LEU A CG  1 
ATOM   6492 C  CD1 . LEU B 2 411 ? 152.266 188.824 102.809 1.00 75.60  ? 402 LEU A CD1 1 
ATOM   6493 C  CD2 . LEU B 2 411 ? 153.065 187.037 101.288 1.00 70.70  ? 402 LEU A CD2 1 
ATOM   6494 N  N   . LEU B 2 412 ? 148.504 185.788 100.810 1.00 80.44  ? 403 LEU A N   1 
ATOM   6495 C  CA  . LEU B 2 412 ? 147.799 185.642 99.545  1.00 86.88  ? 403 LEU A CA  1 
ATOM   6496 C  C   . LEU B 2 412 ? 146.381 186.188 99.619  1.00 94.69  ? 403 LEU A C   1 
ATOM   6497 O  O   . LEU B 2 412 ? 145.803 186.520 98.581  1.00 99.82  ? 403 LEU A O   1 
ATOM   6498 C  CB  . LEU B 2 412 ? 147.771 184.174 99.127  1.00 86.95  ? 403 LEU A CB  1 
ATOM   6499 C  CG  . LEU B 2 412 ? 148.829 183.739 98.119  1.00 83.28  ? 403 LEU A CG  1 
ATOM   6500 C  CD1 . LEU B 2 412 ? 150.206 184.149 98.587  1.00 73.99  ? 403 LEU A CD1 1 
ATOM   6501 C  CD2 . LEU B 2 412 ? 148.761 182.241 97.912  1.00 87.92  ? 403 LEU A CD2 1 
ATOM   6502 N  N   . GLY B 2 413 ? 145.814 186.288 100.816 1.00 92.20  ? 404 GLY A N   1 
ATOM   6503 C  CA  . GLY B 2 413 ? 144.499 186.877 100.989 1.00 91.66  ? 404 GLY A CA  1 
ATOM   6504 C  C   . GLY B 2 413 ? 143.364 186.116 100.341 1.00 101.11 ? 404 GLY A C   1 
ATOM   6505 O  O   . GLY B 2 413 ? 142.509 186.727 99.688  1.00 106.58 ? 404 GLY A O   1 
ATOM   6506 N  N   . CYS B 2 414 ? 143.328 184.799 100.505 1.00 103.10 ? 405 CYS A N   1 
ATOM   6507 C  CA  . CYS B 2 414 ? 142.253 183.981 99.969  1.00 111.14 ? 405 CYS A CA  1 
ATOM   6508 C  C   . CYS B 2 414 ? 141.483 183.324 101.104 1.00 111.20 ? 405 CYS A C   1 
ATOM   6509 O  O   . CYS B 2 414 ? 142.033 183.051 102.173 1.00 108.81 ? 405 CYS A O   1 
ATOM   6510 C  CB  . CYS B 2 414 ? 142.786 182.915 99.008  1.00 112.67 ? 405 CYS A CB  1 
ATOM   6511 S  SG  . CYS B 2 414 ? 144.371 182.190 99.463  1.00 112.04 ? 405 CYS A SG  1 
ATOM   6512 N  N   . ASP B 2 415 ? 140.194 183.083 100.866 1.00 111.54 ? 406 ASP A N   1 
ATOM   6513 C  CA  . ASP B 2 415 ? 139.311 182.512 101.882 1.00 113.97 ? 406 ASP A CA  1 
ATOM   6514 C  C   . ASP B 2 415 ? 138.433 181.453 101.224 1.00 115.30 ? 406 ASP A C   1 
ATOM   6515 O  O   . ASP B 2 415 ? 137.466 181.782 100.531 1.00 113.18 ? 406 ASP A O   1 
ATOM   6516 C  CB  . ASP B 2 415 ? 138.468 183.595 102.545 1.00 119.27 ? 406 ASP A CB  1 
ATOM   6517 C  CG  . ASP B 2 415 ? 139.271 184.835 102.880 1.00 117.61 ? 406 ASP A CG  1 
ATOM   6518 O  OD1 . ASP B 2 415 ? 140.238 184.724 103.663 1.00 115.23 ? 406 ASP A OD1 1 
ATOM   6519 O  OD2 . ASP B 2 415 ? 138.937 185.920 102.361 1.00 115.11 ? 406 ASP A OD2 1 
ATOM   6520 N  N   . LYS B 2 416 ? 138.781 180.185 101.442 1.00 117.67 ? 407 LYS A N   1 
ATOM   6521 C  CA  . LYS B 2 416 ? 137.979 179.030 101.040 1.00 119.67 ? 407 LYS A CA  1 
ATOM   6522 C  C   . LYS B 2 416 ? 137.732 178.977 99.536  1.00 118.20 ? 407 LYS A C   1 
ATOM   6523 O  O   . LYS B 2 416 ? 136.812 178.292 99.080  1.00 114.50 ? 407 LYS A O   1 
ATOM   6524 C  CB  . LYS B 2 416 ? 136.639 178.999 101.785 1.00 121.00 ? 407 LYS A CB  1 
ATOM   6525 C  CG  . LYS B 2 416 ? 136.726 179.259 103.284 1.00 118.67 ? 407 LYS A CG  1 
ATOM   6526 C  CD  . LYS B 2 416 ? 137.816 178.440 103.958 1.00 117.77 ? 407 LYS A CD  1 
ATOM   6527 C  CE  . LYS B 2 416 ? 138.525 179.261 105.024 1.00 115.05 ? 407 LYS A CE  1 
ATOM   6528 N  NZ  . LYS B 2 416 ? 139.781 178.620 105.493 1.00 109.74 ? 407 LYS A NZ  1 
ATOM   6529 N  N   . SER B 2 417 ? 138.539 179.680 98.749  1.00 120.86 ? 408 SER A N   1 
ATOM   6530 C  CA  . SER B 2 417 ? 138.369 179.718 97.304  1.00 120.43 ? 408 SER A CA  1 
ATOM   6531 C  C   . SER B 2 417 ? 139.743 179.881 96.668  1.00 118.35 ? 408 SER A C   1 
ATOM   6532 O  O   . SER B 2 417 ? 140.774 179.764 97.337  1.00 113.81 ? 408 SER A O   1 
ATOM   6533 C  CB  . SER B 2 417 ? 137.408 180.842 96.900  1.00 122.17 ? 408 SER A CB  1 
ATOM   6534 O  OG  . SER B 2 417 ? 138.057 182.101 96.936  1.00 123.14 ? 408 SER A OG  1 
ATOM   6535 N  N   . THR B 2 418 ? 139.759 180.161 95.369  1.00 120.24 ? 409 THR A N   1 
ATOM   6536 C  CA  . THR B 2 418 ? 141.022 180.318 94.665  1.00 120.10 ? 409 THR A CA  1 
ATOM   6537 C  C   . THR B 2 418 ? 141.807 181.488 95.242  1.00 118.32 ? 409 THR A C   1 
ATOM   6538 O  O   . THR B 2 418 ? 141.235 182.497 95.662  1.00 116.71 ? 409 THR A O   1 
ATOM   6539 C  CB  . THR B 2 418 ? 140.776 180.530 93.172  1.00 120.44 ? 409 THR A CB  1 
ATOM   6540 O  OG1 . THR B 2 418 ? 140.279 181.856 92.952  1.00 123.27 ? 409 THR A OG1 1 
ATOM   6541 C  CG2 . THR B 2 418 ? 139.760 179.526 92.656  1.00 114.79 ? 409 THR A CG2 1 
ATOM   6542 N  N   . CYS B 2 419 ? 143.125 181.337 95.282  1.00 117.50 ? 410 CYS A N   1 
ATOM   6543 C  CA  . CYS B 2 419 ? 144.000 182.384 95.784  1.00 118.01 ? 410 CYS A CA  1 
ATOM   6544 C  C   . CYS B 2 419 ? 144.497 183.259 94.637  1.00 115.49 ? 410 CYS A C   1 
ATOM   6545 O  O   . CYS B 2 419 ? 144.377 182.915 93.460  1.00 114.79 ? 410 CYS A O   1 
ATOM   6546 C  CB  . CYS B 2 419 ? 145.179 181.780 96.548  1.00 113.21 ? 410 CYS A CB  1 
ATOM   6547 S  SG  . CYS B 2 419 ? 144.708 180.813 98.010  1.00 114.55 ? 410 CYS A SG  1 
ATOM   6548 N  N   . THR B 2 420 ? 145.054 184.415 95.000  1.00 110.34 ? 411 THR A N   1 
ATOM   6549 C  CA  . THR B 2 420 ? 145.499 185.369 93.992  1.00 110.07 ? 411 THR A CA  1 
ATOM   6550 C  C   . THR B 2 420 ? 146.796 184.946 93.316  1.00 108.05 ? 411 THR A C   1 
ATOM   6551 O  O   . THR B 2 420 ? 147.099 185.444 92.227  1.00 107.69 ? 411 THR A O   1 
ATOM   6552 C  CB  . THR B 2 420 ? 145.665 186.749 94.619  1.00 111.63 ? 411 THR A CB  1 
ATOM   6553 O  OG1 . THR B 2 420 ? 146.955 186.841 95.232  1.00 107.96 ? 411 THR A OG1 1 
ATOM   6554 C  CG2 . THR B 2 420 ? 144.589 186.985 95.666  1.00 108.99 ? 411 THR A CG2 1 
ATOM   6555 N  N   . LYS B 2 421 ? 147.563 184.048 93.937  1.00 106.71 ? 412 LYS A N   1 
ATOM   6556 C  CA  . LYS B 2 421 ? 148.764 183.462 93.335  1.00 105.12 ? 412 LYS A CA  1 
ATOM   6557 C  C   . LYS B 2 421 ? 149.780 184.530 92.930  1.00 105.51 ? 412 LYS A C   1 
ATOM   6558 O  O   . LYS B 2 421 ? 150.479 184.395 91.924  1.00 104.73 ? 412 LYS A O   1 
ATOM   6559 C  CB  . LYS B 2 421 ? 148.409 182.583 92.132  1.00 103.74 ? 412 LYS A CB  1 
ATOM   6560 C  CG  . LYS B 2 421 ? 147.156 181.738 92.300  1.00 105.42 ? 412 LYS A CG  1 
ATOM   6561 C  CD  . LYS B 2 421 ? 147.245 180.821 93.502  1.00 103.17 ? 412 LYS A CD  1 
ATOM   6562 C  CE  . LYS B 2 421 ? 146.242 179.681 93.404  1.00 102.11 ? 412 LYS A CE  1 
ATOM   6563 N  NZ  . LYS B 2 421 ? 144.889 180.146 92.995  1.00 104.58 ? 412 LYS A NZ  1 
ATOM   6564 N  N   . ARG B 2 422 ? 149.870 185.597 93.716  1.00 102.85 ? 413 ARG A N   1 
ATOM   6565 C  CA  . ARG B 2 422 ? 150.836 186.644 93.424  1.00 96.20  ? 413 ARG A CA  1 
ATOM   6566 C  C   . ARG B 2 422 ? 152.238 186.206 93.833  1.00 98.63  ? 413 ARG A C   1 
ATOM   6567 O  O   . ARG B 2 422 ? 152.425 185.227 94.559  1.00 99.75  ? 413 ARG A O   1 
ATOM   6568 C  CB  . ARG B 2 422 ? 150.466 187.938 94.144  1.00 91.13  ? 413 ARG A CB  1 
ATOM   6569 C  CG  . ARG B 2 422 ? 149.961 187.720 95.553  1.00 90.87  ? 413 ARG A CG  1 
ATOM   6570 C  CD  . ARG B 2 422 ? 149.711 189.031 96.263  1.00 87.81  ? 413 ARG A CD  1 
ATOM   6571 N  NE  . ARG B 2 422 ? 150.909 189.515 96.934  1.00 88.33  ? 413 ARG A NE  1 
ATOM   6572 C  CZ  . ARG B 2 422 ? 150.912 190.092 98.127  1.00 87.10  ? 413 ARG A CZ  1 
ATOM   6573 N  NH1 . ARG B 2 422 ? 149.793 190.278 98.806  1.00 90.34  ? 413 ARG A NH1 1 
ATOM   6574 N  NH2 . ARG B 2 422 ? 152.066 190.489 98.653  1.00 82.07  ? 413 ARG A NH2 1 
ATOM   6575 N  N   . VAL B 2 423 ? 153.235 186.947 93.348  1.00 98.89  ? 414 VAL A N   1 
ATOM   6576 C  CA  . VAL B 2 423 ? 154.614 186.671 93.726  1.00 97.67  ? 414 VAL A CA  1 
ATOM   6577 C  C   . VAL B 2 423 ? 154.816 187.030 95.192  1.00 90.02  ? 414 VAL A C   1 
ATOM   6578 O  O   . VAL B 2 423 ? 154.296 188.040 95.684  1.00 88.85  ? 414 VAL A O   1 
ATOM   6579 C  CB  . VAL B 2 423 ? 155.590 187.430 92.811  1.00 96.62  ? 414 VAL A CB  1 
ATOM   6580 C  CG1 . VAL B 2 423 ? 155.524 188.928 93.061  1.00 91.96  ? 414 VAL A CG1 1 
ATOM   6581 C  CG2 . VAL B 2 423 ? 157.003 186.918 93.004  1.00 92.76  ? 414 VAL A CG2 1 
ATOM   6582 N  N   . VAL B 2 424 ? 155.551 186.186 95.907  1.00 81.74  ? 415 VAL A N   1 
ATOM   6583 C  CA  . VAL B 2 424 ? 155.730 186.328 97.345  1.00 81.12  ? 415 VAL A CA  1 
ATOM   6584 C  C   . VAL B 2 424 ? 157.213 186.502 97.626  1.00 84.91  ? 415 VAL A C   1 
ATOM   6585 O  O   . VAL B 2 424 ? 158.006 185.576 97.420  1.00 84.71  ? 415 VAL A O   1 
ATOM   6586 C  CB  . VAL B 2 424 ? 155.165 185.130 98.114  1.00 76.69  ? 415 VAL A CB  1 
ATOM   6587 C  CG1 . VAL B 2 424 ? 155.624 185.170 99.551  1.00 75.79  ? 415 VAL A CG1 1 
ATOM   6588 C  CG2 . VAL B 2 424 ? 153.658 185.137 98.046  1.00 79.65  ? 415 VAL A CG2 1 
ATOM   6589 N  N   . TYR B 2 425 ? 157.585 187.679 98.099  1.00 85.28  ? 416 TYR A N   1 
ATOM   6590 C  CA  . TYR B 2 425 ? 158.943 187.894 98.556  1.00 80.99  ? 416 TYR A CA  1 
ATOM   6591 C  C   . TYR B 2 425 ? 159.089 187.414 99.998  1.00 80.22  ? 416 TYR A C   1 
ATOM   6592 O  O   . TYR B 2 425 ? 158.132 187.464 100.774 1.00 80.67  ? 416 TYR A O   1 
ATOM   6593 C  CB  . TYR B 2 425 ? 159.307 189.369 98.463  1.00 80.27  ? 416 TYR A CB  1 
ATOM   6594 C  CG  . TYR B 2 425 ? 159.215 189.937 97.071  1.00 84.66  ? 416 TYR A CG  1 
ATOM   6595 C  CD1 . TYR B 2 425 ? 159.750 189.259 95.987  1.00 87.66  ? 416 TYR A CD1 1 
ATOM   6596 C  CD2 . TYR B 2 425 ? 158.603 191.157 96.840  1.00 87.12  ? 416 TYR A CD2 1 
ATOM   6597 C  CE1 . TYR B 2 425 ? 159.671 189.777 94.711  1.00 89.22  ? 416 TYR A CE1 1 
ATOM   6598 C  CE2 . TYR B 2 425 ? 158.520 191.685 95.569  1.00 90.66  ? 416 TYR A CE2 1 
ATOM   6599 C  CZ  . TYR B 2 425 ? 159.055 190.991 94.508  1.00 91.31  ? 416 TYR A CZ  1 
ATOM   6600 O  OH  . TYR B 2 425 ? 158.973 191.517 93.241  1.00 90.29  ? 416 TYR A OH  1 
ATOM   6601 N  N   . PRO B 2 426 ? 160.274 186.935 100.376 1.00 80.49  ? 417 PRO A N   1 
ATOM   6602 C  CA  . PRO B 2 426 ? 160.448 186.426 101.746 1.00 79.25  ? 417 PRO A CA  1 
ATOM   6603 C  C   . PRO B 2 426 ? 160.177 187.455 102.830 1.00 77.24  ? 417 PRO A C   1 
ATOM   6604 O  O   . PRO B 2 426 ? 159.611 187.108 103.875 1.00 74.94  ? 417 PRO A O   1 
ATOM   6605 C  CB  . PRO B 2 426 ? 161.909 185.965 101.759 1.00 76.92  ? 417 PRO A CB  1 
ATOM   6606 C  CG  . PRO B 2 426 ? 162.554 186.674 100.616 1.00 79.65  ? 417 PRO A CG  1 
ATOM   6607 C  CD  . PRO B 2 426 ? 161.499 186.797 99.576  1.00 80.21  ? 417 PRO A CD  1 
ATOM   6608 N  N   . TRP B 2 427 ? 160.563 188.715 102.615 1.00 77.95  ? 418 TRP A N   1 
ATOM   6609 C  CA  . TRP B 2 427 ? 160.357 189.722 103.650 1.00 76.94  ? 418 TRP A CA  1 
ATOM   6610 C  C   . TRP B 2 427 ? 158.878 190.006 103.869 1.00 81.32  ? 418 TRP A C   1 
ATOM   6611 O  O   . TRP B 2 427 ? 158.463 190.277 105.001 1.00 83.41  ? 418 TRP A O   1 
ATOM   6612 C  CB  . TRP B 2 427 ? 161.104 191.008 103.303 1.00 74.52  ? 418 TRP A CB  1 
ATOM   6613 C  CG  . TRP B 2 427 ? 160.611 191.688 102.075 1.00 80.01  ? 418 TRP A CG  1 
ATOM   6614 C  CD1 . TRP B 2 427 ? 161.040 191.483 100.801 1.00 84.75  ? 418 TRP A CD1 1 
ATOM   6615 C  CD2 . TRP B 2 427 ? 159.591 192.688 102.000 1.00 83.00  ? 418 TRP A CD2 1 
ATOM   6616 N  NE1 . TRP B 2 427 ? 160.351 192.293 99.934  1.00 86.96  ? 418 TRP A NE1 1 
ATOM   6617 C  CE2 . TRP B 2 427 ? 159.454 193.042 100.647 1.00 85.64  ? 418 TRP A CE2 1 
ATOM   6618 C  CE3 . TRP B 2 427 ? 158.780 193.316 102.945 1.00 84.09  ? 418 TRP A CE3 1 
ATOM   6619 C  CZ2 . TRP B 2 427 ? 158.541 193.996 100.216 1.00 84.48  ? 418 TRP A CZ2 1 
ATOM   6620 C  CZ3 . TRP B 2 427 ? 157.873 194.263 102.515 1.00 86.15  ? 418 TRP A CZ3 1 
ATOM   6621 C  CH2 . TRP B 2 427 ? 157.761 194.594 101.164 1.00 85.24  ? 418 TRP A CH2 1 
ATOM   6622 N  N   . GLN B 2 428 ? 158.067 189.942 102.812 1.00 79.10  ? 419 GLN A N   1 
ATOM   6623 C  CA  . GLN B 2 428 ? 156.628 190.092 102.991 1.00 75.32  ? 419 GLN A CA  1 
ATOM   6624 C  C   . GLN B 2 428 ? 156.069 188.977 103.860 1.00 72.95  ? 419 GLN A C   1 
ATOM   6625 O  O   . GLN B 2 428 ? 155.239 189.222 104.744 1.00 74.21  ? 419 GLN A O   1 
ATOM   6626 C  CB  . GLN B 2 428 ? 155.927 190.116 101.635 1.00 78.49  ? 419 GLN A CB  1 
ATOM   6627 C  CG  . GLN B 2 428 ? 156.225 191.352 100.812 1.00 85.16  ? 419 GLN A CG  1 
ATOM   6628 C  CD  . GLN B 2 428 ? 155.497 191.354 99.487  1.00 91.24  ? 419 GLN A CD  1 
ATOM   6629 O  OE1 . GLN B 2 428 ? 154.880 190.362 99.104  1.00 91.09  ? 419 GLN A OE1 1 
ATOM   6630 N  NE2 . GLN B 2 428 ? 155.560 192.475 98.779  1.00 89.88  ? 419 GLN A NE2 1 
ATOM   6631 N  N   . LEU B 2 429 ? 156.515 187.743 103.625 1.00 72.07  ? 420 LEU A N   1 
ATOM   6632 C  CA  . LEU B 2 429 ? 156.061 186.633 104.452 1.00 70.83  ? 420 LEU A CA  1 
ATOM   6633 C  C   . LEU B 2 429 ? 156.504 186.811 105.896 1.00 70.75  ? 420 LEU A C   1 
ATOM   6634 O  O   . LEU B 2 429 ? 155.745 186.514 106.823 1.00 71.34  ? 420 LEU A O   1 
ATOM   6635 C  CB  . LEU B 2 429 ? 156.569 185.308 103.894 1.00 65.31  ? 420 LEU A CB  1 
ATOM   6636 C  CG  . LEU B 2 429 ? 156.080 184.102 104.687 1.00 63.63  ? 420 LEU A CG  1 
ATOM   6637 C  CD1 . LEU B 2 429 ? 154.581 183.964 104.540 1.00 67.45  ? 420 LEU A CD1 1 
ATOM   6638 C  CD2 . LEU B 2 429 ? 156.776 182.847 104.220 1.00 64.62  ? 420 LEU A CD2 1 
ATOM   6639 N  N   . LEU B 2 430 ? 157.728 187.293 106.110 1.00 69.08  ? 421 LEU A N   1 
ATOM   6640 C  CA  . LEU B 2 430 ? 158.168 187.560 107.476 1.00 66.24  ? 421 LEU A CA  1 
ATOM   6641 C  C   . LEU B 2 430 ? 157.287 188.607 108.136 1.00 68.84  ? 421 LEU A C   1 
ATOM   6642 O  O   . LEU B 2 430 ? 156.922 188.474 109.307 1.00 67.94  ? 421 LEU A O   1 
ATOM   6643 C  CB  . LEU B 2 430 ? 159.624 188.015 107.493 1.00 66.37  ? 421 LEU A CB  1 
ATOM   6644 C  CG  . LEU B 2 430 ? 160.100 188.457 108.874 1.00 63.05  ? 421 LEU A CG  1 
ATOM   6645 C  CD1 . LEU B 2 430 ? 160.474 187.253 109.707 1.00 62.15  ? 421 LEU A CD1 1 
ATOM   6646 C  CD2 . LEU B 2 430 ? 161.261 189.416 108.766 1.00 66.13  ? 421 LEU A CD2 1 
ATOM   6647 N  N   . GLU B 2 431 ? 156.932 189.656 107.396 1.00 73.39  ? 422 GLU A N   1 
ATOM   6648 C  CA  . GLU B 2 431 ? 156.088 190.703 107.961 1.00 75.43  ? 422 GLU A CA  1 
ATOM   6649 C  C   . GLU B 2 431 ? 154.709 190.167 108.316 1.00 74.44  ? 422 GLU A C   1 
ATOM   6650 O  O   . GLU B 2 431 ? 154.129 190.553 109.336 1.00 75.99  ? 422 GLU A O   1 
ATOM   6651 C  CB  . GLU B 2 431 ? 155.973 191.868 106.983 1.00 75.63  ? 422 GLU A CB  1 
ATOM   6652 C  CG  . GLU B 2 431 ? 155.562 193.168 107.635 1.00 83.14  ? 422 GLU A CG  1 
ATOM   6653 C  CD  . GLU B 2 431 ? 155.977 194.372 106.825 1.00 93.83  ? 422 GLU A CD  1 
ATOM   6654 O  OE1 . GLU B 2 431 ? 155.729 194.377 105.601 1.00 98.05  ? 422 GLU A OE1 1 
ATOM   6655 O  OE2 . GLU B 2 431 ? 156.550 195.314 107.411 1.00 99.80  ? 422 GLU A OE2 1 
ATOM   6656 N  N   . GLU B 2 432 ? 154.162 189.288 107.481 1.00 70.61  ? 423 GLU A N   1 
ATOM   6657 C  CA  . GLU B 2 432 ? 152.831 188.754 107.739 1.00 68.51  ? 423 GLU A CA  1 
ATOM   6658 C  C   . GLU B 2 432 ? 152.827 187.590 108.719 1.00 69.22  ? 423 GLU A C   1 
ATOM   6659 O  O   . GLU B 2 432 ? 151.751 187.201 109.181 1.00 71.31  ? 423 GLU A O   1 
ATOM   6660 C  CB  . GLU B 2 432 ? 152.178 188.313 106.432 1.00 72.61  ? 423 GLU A CB  1 
ATOM   6661 C  CG  . GLU B 2 432 ? 150.696 188.631 106.347 1.00 77.76  ? 423 GLU A CG  1 
ATOM   6662 C  CD  . GLU B 2 432 ? 150.426 190.117 106.208 1.00 83.61  ? 423 GLU A CD  1 
ATOM   6663 O  OE1 . GLU B 2 432 ? 150.803 190.698 105.169 1.00 82.94  ? 423 GLU A OE1 1 
ATOM   6664 O  OE2 . GLU B 2 432 ? 149.837 190.705 107.137 1.00 84.40  ? 423 GLU A OE2 1 
ATOM   6665 N  N   . ILE B 2 433 ? 153.990 187.020 109.039 1.00 69.79  ? 424 ILE A N   1 
ATOM   6666 C  CA  . ILE B 2 433 ? 154.032 185.855 109.917 1.00 65.54  ? 424 ILE A CA  1 
ATOM   6667 C  C   . ILE B 2 433 ? 153.994 186.218 111.394 1.00 66.50  ? 424 ILE A C   1 
ATOM   6668 O  O   . ILE B 2 433 ? 153.677 185.360 112.222 1.00 67.10  ? 424 ILE A O   1 
ATOM   6669 C  CB  . ILE B 2 433 ? 155.285 185.014 109.627 1.00 59.77  ? 424 ILE A CB  1 
ATOM   6670 C  CG1 . ILE B 2 433 ? 155.076 183.563 110.034 1.00 54.35  ? 424 ILE A CG1 1 
ATOM   6671 C  CG2 . ILE B 2 433 ? 156.471 185.563 110.363 1.00 61.97  ? 424 ILE A CG2 1 
ATOM   6672 C  CD1 . ILE B 2 433 ? 156.156 182.655 109.527 1.00 53.92  ? 424 ILE A CD1 1 
ATOM   6673 N  N   . TRP B 2 434 ? 154.310 187.460 111.758 1.00 67.25  ? 425 TRP A N   1 
ATOM   6674 C  CA  . TRP B 2 434 ? 154.242 187.840 113.162 1.00 66.05  ? 425 TRP A CA  1 
ATOM   6675 C  C   . TRP B 2 434 ? 152.812 187.877 113.674 1.00 69.28  ? 425 TRP A C   1 
ATOM   6676 O  O   . TRP B 2 434 ? 152.598 187.786 114.886 1.00 68.21  ? 425 TRP A O   1 
ATOM   6677 C  CB  . TRP B 2 434 ? 154.887 189.207 113.375 1.00 66.68  ? 425 TRP A CB  1 
ATOM   6678 C  CG  . TRP B 2 434 ? 156.366 189.220 113.218 1.00 68.67  ? 425 TRP A CG  1 
ATOM   6679 C  CD1 . TRP B 2 434 ? 157.058 189.491 112.082 1.00 72.60  ? 425 TRP A CD1 1 
ATOM   6680 C  CD2 . TRP B 2 434 ? 157.342 188.969 114.232 1.00 67.81  ? 425 TRP A CD2 1 
ATOM   6681 N  NE1 . TRP B 2 434 ? 158.405 189.417 112.318 1.00 73.60  ? 425 TRP A NE1 1 
ATOM   6682 C  CE2 . TRP B 2 434 ? 158.606 189.097 113.633 1.00 69.94  ? 425 TRP A CE2 1 
ATOM   6683 C  CE3 . TRP B 2 434 ? 157.269 188.646 115.587 1.00 71.09  ? 425 TRP A CE3 1 
ATOM   6684 C  CZ2 . TRP B 2 434 ? 159.786 188.913 114.339 1.00 71.10  ? 425 TRP A CZ2 1 
ATOM   6685 C  CZ3 . TRP B 2 434 ? 158.441 188.464 116.286 1.00 76.12  ? 425 TRP A CZ3 1 
ATOM   6686 C  CH2 . TRP B 2 434 ? 159.683 188.598 115.662 1.00 75.70  ? 425 TRP A CH2 1 
ATOM   6687 N  N   . LYS B 2 435 ? 151.833 187.999 112.783 1.00 70.10  ? 426 LYS A N   1 
ATOM   6688 C  CA  . LYS B 2 435 ? 150.447 188.213 113.167 1.00 70.95  ? 426 LYS A CA  1 
ATOM   6689 C  C   . LYS B 2 435 ? 149.601 186.951 113.083 1.00 71.07  ? 426 LYS A C   1 
ATOM   6690 O  O   . LYS B 2 435 ? 148.373 187.041 113.157 1.00 72.35  ? 426 LYS A O   1 
ATOM   6691 C  CB  . LYS B 2 435 ? 149.831 189.308 112.298 1.00 70.63  ? 426 LYS A CB  1 
ATOM   6692 C  CG  . LYS B 2 435 ? 150.784 190.440 111.966 1.00 68.56  ? 426 LYS A CG  1 
ATOM   6693 C  CD  . LYS B 2 435 ? 150.372 191.146 110.685 1.00 74.51  ? 426 LYS A CD  1 
ATOM   6694 C  CE  . LYS B 2 435 ? 148.871 191.383 110.642 1.00 74.35  ? 426 LYS A CE  1 
ATOM   6695 N  NZ  . LYS B 2 435 ? 148.415 191.856 109.309 1.00 69.03  ? 426 LYS A NZ  1 
ATOM   6696 N  N   . VAL B 2 436 ? 150.219 185.780 112.928 1.00 70.06  ? 427 VAL A N   1 
ATOM   6697 C  CA  . VAL B 2 436 ? 149.450 184.546 112.856 1.00 69.47  ? 427 VAL A CA  1 
ATOM   6698 C  C   . VAL B 2 436 ? 148.811 184.267 114.207 1.00 76.51  ? 427 VAL A C   1 
ATOM   6699 O  O   . VAL B 2 436 ? 149.415 184.493 115.263 1.00 78.84  ? 427 VAL A O   1 
ATOM   6700 C  CB  . VAL B 2 436 ? 150.337 183.372 112.413 1.00 60.77  ? 427 VAL A CB  1 
ATOM   6701 C  CG1 . VAL B 2 436 ? 150.780 183.565 110.983 1.00 63.86  ? 427 VAL A CG1 1 
ATOM   6702 C  CG2 . VAL B 2 436 ? 151.527 183.237 113.327 1.00 59.98  ? 427 VAL A CG2 1 
ATOM   6703 N  N   . ASN B 2 437 ? 147.570 183.790 114.179 1.00 75.97  ? 428 ASN A N   1 
ATOM   6704 C  CA  . ASN B 2 437 ? 146.860 183.465 115.411 1.00 76.91  ? 428 ASN A CA  1 
ATOM   6705 C  C   . ASN B 2 437 ? 145.744 182.492 115.060 1.00 81.50  ? 428 ASN A C   1 
ATOM   6706 O  O   . ASN B 2 437 ? 144.802 182.863 114.353 1.00 84.16  ? 428 ASN A O   1 
ATOM   6707 C  CB  . ASN B 2 437 ? 146.317 184.725 116.070 1.00 78.20  ? 428 ASN A CB  1 
ATOM   6708 C  CG  . ASN B 2 437 ? 145.751 184.457 117.437 1.00 84.26  ? 428 ASN A CG  1 
ATOM   6709 O  OD1 . ASN B 2 437 ? 146.098 183.465 118.073 1.00 85.03  ? 428 ASN A OD1 1 
ATOM   6710 N  ND2 . ASN B 2 437 ? 144.878 185.337 117.906 1.00 89.58  ? 428 ASN A ND2 1 
ATOM   6711 N  N   . PHE B 2 438 ? 145.855 181.258 115.542 1.00 81.60  ? 429 PHE A N   1 
ATOM   6712 C  CA  . PHE B 2 438 ? 144.887 180.218 115.220 1.00 80.88  ? 429 PHE A CA  1 
ATOM   6713 C  C   . PHE B 2 438 ? 144.929 179.156 116.307 1.00 77.79  ? 429 PHE A C   1 
ATOM   6714 O  O   . PHE B 2 438 ? 145.818 179.146 117.159 1.00 77.37  ? 429 PHE A O   1 
ATOM   6715 C  CB  . PHE B 2 438 ? 145.166 179.600 113.848 1.00 79.58  ? 429 PHE A CB  1 
ATOM   6716 C  CG  . PHE B 2 438 ? 146.597 179.182 113.647 1.00 75.89  ? 429 PHE A CG  1 
ATOM   6717 C  CD1 . PHE B 2 438 ? 147.049 177.959 114.102 1.00 73.59  ? 429 PHE A CD1 1 
ATOM   6718 C  CD2 . PHE B 2 438 ? 147.485 180.006 112.985 1.00 71.57  ? 429 PHE A CD2 1 
ATOM   6719 C  CE1 . PHE B 2 438 ? 148.358 177.577 113.914 1.00 67.78  ? 429 PHE A CE1 1 
ATOM   6720 C  CE2 . PHE B 2 438 ? 148.793 179.623 112.795 1.00 69.05  ? 429 PHE A CE2 1 
ATOM   6721 C  CZ  . PHE B 2 438 ? 149.228 178.409 113.260 1.00 64.53  ? 429 PHE A CZ  1 
ATOM   6722 N  N   . THR B 2 439 ? 143.948 178.261 116.267 1.00 79.10  ? 430 THR A N   1 
ATOM   6723 C  CA  . THR B 2 439 ? 143.895 177.120 117.169 1.00 80.53  ? 430 THR A CA  1 
ATOM   6724 C  C   . THR B 2 439 ? 144.367 175.882 116.420 1.00 80.06  ? 430 THR A C   1 
ATOM   6725 O  O   . THR B 2 439 ? 143.753 175.480 115.426 1.00 78.63  ? 430 THR A O   1 
ATOM   6726 C  CB  . THR B 2 439 ? 142.487 176.905 117.719 1.00 81.17  ? 430 THR A CB  1 
ATOM   6727 O  OG1 . THR B 2 439 ? 141.561 176.772 116.635 1.00 85.55  ? 430 THR A OG1 1 
ATOM   6728 C  CG2 . THR B 2 439 ? 142.075 178.074 118.589 1.00 80.19  ? 430 THR A CG2 1 
ATOM   6729 N  N   . LEU B 2 440 ? 145.452 175.281 116.899 1.00 78.34  ? 431 LEU A N   1 
ATOM   6730 C  CA  . LEU B 2 440 ? 146.025 174.078 116.309 1.00 72.09  ? 431 LEU A CA  1 
ATOM   6731 C  C   . LEU B 2 440 ? 146.013 172.981 117.363 1.00 72.27  ? 431 LEU A C   1 
ATOM   6732 O  O   . LEU B 2 440 ? 146.693 173.097 118.386 1.00 75.36  ? 431 LEU A O   1 
ATOM   6733 C  CB  . LEU B 2 440 ? 147.443 174.336 115.812 1.00 70.45  ? 431 LEU A CB  1 
ATOM   6734 C  CG  . LEU B 2 440 ? 148.124 173.125 115.186 1.00 68.88  ? 431 LEU A CG  1 
ATOM   6735 C  CD1 . LEU B 2 440 ? 147.319 172.636 114.000 1.00 65.53  ? 431 LEU A CD1 1 
ATOM   6736 C  CD2 . LEU B 2 440 ? 149.540 173.464 114.773 1.00 64.65  ? 431 LEU A CD2 1 
ATOM   6737 N  N   . LEU B 2 441 ? 145.246 171.922 117.109 1.00 69.59  ? 432 LEU A N   1 
ATOM   6738 C  CA  . LEU B 2 441 ? 145.117 170.799 118.036 1.00 70.13  ? 432 LEU A CA  1 
ATOM   6739 C  C   . LEU B 2 441 ? 144.740 171.284 119.432 1.00 77.61  ? 432 LEU A C   1 
ATOM   6740 O  O   . LEU B 2 441 ? 145.327 170.885 120.439 1.00 80.96  ? 432 LEU A O   1 
ATOM   6741 C  CB  . LEU B 2 441 ? 146.397 169.968 118.070 1.00 65.41  ? 432 LEU A CB  1 
ATOM   6742 C  CG  . LEU B 2 441 ? 146.697 169.217 116.778 1.00 62.07  ? 432 LEU A CG  1 
ATOM   6743 C  CD1 . LEU B 2 441 ? 148.040 168.526 116.867 1.00 66.29  ? 432 LEU A CD1 1 
ATOM   6744 C  CD2 . LEU B 2 441 ? 145.597 168.222 116.484 1.00 58.53  ? 432 LEU A CD2 1 
ATOM   6745 N  N   . ASP B 2 442 ? 143.750 172.174 119.477 1.00 79.78  ? 433 ASP A N   1 
ATOM   6746 C  CA  . ASP B 2 442 ? 143.242 172.739 120.726 1.00 84.33  ? 433 ASP A CA  1 
ATOM   6747 C  C   . ASP B 2 442 ? 144.351 173.424 121.524 1.00 84.18  ? 433 ASP A C   1 
ATOM   6748 O  O   . ASP B 2 442 ? 144.409 173.335 122.750 1.00 86.85  ? 433 ASP A O   1 
ATOM   6749 C  CB  . ASP B 2 442 ? 142.539 171.674 121.566 1.00 90.85  ? 433 ASP A CB  1 
ATOM   6750 C  CG  . ASP B 2 442 ? 141.216 171.245 120.966 1.00 96.29  ? 433 ASP A CG  1 
ATOM   6751 O  OD1 . ASP B 2 442 ? 141.147 171.089 119.729 1.00 89.65  ? 433 ASP A OD1 1 
ATOM   6752 O  OD2 . ASP B 2 442 ? 140.244 171.071 121.730 1.00 104.66 ? 433 ASP A OD2 1 
ATOM   6753 N  N   . HIS B 2 443 ? 145.238 174.112 120.814 1.00 81.39  ? 434 HIS A N   1 
ATOM   6754 C  CA  . HIS B 2 443 ? 146.267 174.951 121.405 1.00 80.02  ? 434 HIS A CA  1 
ATOM   6755 C  C   . HIS B 2 443 ? 146.266 176.291 120.690 1.00 83.91  ? 434 HIS A C   1 
ATOM   6756 O  O   . HIS B 2 443 ? 145.811 176.405 119.551 1.00 85.59  ? 434 HIS A O   1 
ATOM   6757 C  CB  . HIS B 2 443 ? 147.659 174.321 121.302 1.00 78.82  ? 434 HIS A CB  1 
ATOM   6758 C  CG  . HIS B 2 443 ? 148.139 173.687 122.568 1.00 79.44  ? 434 HIS A CG  1 
ATOM   6759 N  ND1 . HIS B 2 443 ? 147.797 172.404 122.937 1.00 82.57  ? 434 HIS A ND1 1 
ATOM   6760 C  CD2 . HIS B 2 443 ? 148.953 174.155 123.544 1.00 81.55  ? 434 HIS A CD2 1 
ATOM   6761 C  CE1 . HIS B 2 443 ? 148.372 172.113 124.090 1.00 86.88  ? 434 HIS A CE1 1 
ATOM   6762 N  NE2 . HIS B 2 443 ? 149.079 173.158 124.479 1.00 85.31  ? 434 HIS A NE2 1 
ATOM   6763 N  N   . GLN B 2 444 ? 146.776 177.312 121.366 1.00 80.86  ? 435 GLN A N   1 
ATOM   6764 C  CA  . GLN B 2 444 ? 146.862 178.649 120.796 1.00 77.50  ? 435 GLN A CA  1 
ATOM   6765 C  C   . GLN B 2 444 ? 148.267 178.886 120.266 1.00 72.46  ? 435 GLN A C   1 
ATOM   6766 O  O   . GLN B 2 444 ? 149.251 178.605 120.957 1.00 75.18  ? 435 GLN A O   1 
ATOM   6767 C  CB  . GLN B 2 444 ? 146.497 179.710 121.832 1.00 82.39  ? 435 GLN A CB  1 
ATOM   6768 C  CG  . GLN B 2 444 ? 145.766 180.896 121.244 1.00 85.70  ? 435 GLN A CG  1 
ATOM   6769 C  CD  . GLN B 2 444 ? 144.493 180.495 120.538 1.00 87.79  ? 435 GLN A CD  1 
ATOM   6770 O  OE1 . GLN B 2 444 ? 143.747 179.642 121.016 1.00 89.88  ? 435 GLN A OE1 1 
ATOM   6771 N  NE2 . GLN B 2 444 ? 144.236 181.108 119.391 1.00 85.01  ? 435 GLN A NE2 1 
ATOM   6772 N  N   . ILE B 2 445 ? 148.357 179.394 119.041 1.00 70.28  ? 436 ILE A N   1 
ATOM   6773 C  CA  . ILE B 2 445 ? 149.632 179.656 118.384 1.00 71.88  ? 436 ILE A CA  1 
ATOM   6774 C  C   . ILE B 2 445 ? 149.667 181.124 117.987 1.00 74.05  ? 436 ILE A C   1 
ATOM   6775 O  O   . ILE B 2 445 ? 148.965 181.542 117.058 1.00 74.83  ? 436 ILE A O   1 
ATOM   6776 C  CB  . ILE B 2 445 ? 149.846 178.752 117.164 1.00 70.58  ? 436 ILE A CB  1 
ATOM   6777 C  CG1 . ILE B 2 445 ? 149.921 177.295 117.603 1.00 72.74  ? 436 ILE A CG1 1 
ATOM   6778 C  CG2 . ILE B 2 445 ? 151.116 179.138 116.435 1.00 65.52  ? 436 ILE A CG2 1 
ATOM   6779 C  CD1 . ILE B 2 445 ? 150.973 177.038 118.645 1.00 73.47  ? 436 ILE A CD1 1 
ATOM   6780 N  N   . PHE B 2 446 ? 150.475 181.907 118.694 1.00 72.70  ? 437 PHE A N   1 
ATOM   6781 C  CA  . PHE B 2 446 ? 150.751 183.284 118.321 1.00 68.08  ? 437 PHE A CA  1 
ATOM   6782 C  C   . PHE B 2 446 ? 152.143 183.628 118.817 1.00 65.90  ? 437 PHE A C   1 
ATOM   6783 O  O   . PHE B 2 446 ? 152.655 183.015 119.753 1.00 73.13  ? 437 PHE A O   1 
ATOM   6784 C  CB  . PHE B 2 446 ? 149.710 184.254 118.886 1.00 72.16  ? 437 PHE A CB  1 
ATOM   6785 C  CG  . PHE B 2 446 ? 149.503 184.132 120.364 1.00 73.59  ? 437 PHE A CG  1 
ATOM   6786 C  CD1 . PHE B 2 446 ? 150.315 184.812 121.248 1.00 74.31  ? 437 PHE A CD1 1 
ATOM   6787 C  CD2 . PHE B 2 446 ? 148.485 183.350 120.868 1.00 77.32  ? 437 PHE A CD2 1 
ATOM   6788 C  CE1 . PHE B 2 446 ? 150.125 184.705 122.605 1.00 77.72  ? 437 PHE A CE1 1 
ATOM   6789 C  CE2 . PHE B 2 446 ? 148.291 183.241 122.224 1.00 83.72  ? 437 PHE A CE2 1 
ATOM   6790 C  CZ  . PHE B 2 446 ? 149.112 183.919 123.093 1.00 85.55  ? 437 PHE A CZ  1 
ATOM   6791 N  N   . PHE B 2 447 ? 152.753 184.619 118.185 1.00 59.20  ? 438 PHE A N   1 
ATOM   6792 C  CA  . PHE B 2 447 ? 154.151 184.935 118.429 1.00 65.32  ? 438 PHE A CA  1 
ATOM   6793 C  C   . PHE B 2 447 ? 154.264 186.153 119.334 1.00 73.82  ? 438 PHE A C   1 
ATOM   6794 O  O   . PHE B 2 447 ? 153.629 187.182 119.083 1.00 76.41  ? 438 PHE A O   1 
ATOM   6795 C  CB  . PHE B 2 447 ? 154.886 185.177 117.111 1.00 67.24  ? 438 PHE A CB  1 
ATOM   6796 C  CG  . PHE B 2 447 ? 155.206 183.918 116.360 1.00 66.01  ? 438 PHE A CG  1 
ATOM   6797 C  CD1 . PHE B 2 447 ? 154.294 183.372 115.483 1.00 63.69  ? 438 PHE A CD1 1 
ATOM   6798 C  CD2 . PHE B 2 447 ? 156.411 183.278 116.535 1.00 65.67  ? 438 PHE A CD2 1 
ATOM   6799 C  CE1 . PHE B 2 447 ? 154.579 182.216 114.795 1.00 54.18  ? 438 PHE A CE1 1 
ATOM   6800 C  CE2 . PHE B 2 447 ? 156.696 182.122 115.846 1.00 61.26  ? 438 PHE A CE2 1 
ATOM   6801 C  CZ  . PHE B 2 447 ? 155.780 181.592 114.978 1.00 52.69  ? 438 PHE A CZ  1 
ATOM   6802 N  N   . ASP B 2 448 ? 155.077 186.030 120.380 1.00 78.66  ? 439 ASP A N   1 
ATOM   6803 C  CA  . ASP B 2 448 ? 155.374 187.135 121.272 1.00 77.38  ? 439 ASP A CA  1 
ATOM   6804 C  C   . ASP B 2 448 ? 156.084 188.236 120.495 1.00 82.26  ? 439 ASP A C   1 
ATOM   6805 O  O   . ASP B 2 448 ? 156.489 188.040 119.348 1.00 84.51  ? 439 ASP A O   1 
ATOM   6806 C  CB  . ASP B 2 448 ? 156.245 186.659 122.437 1.00 79.90  ? 439 ASP A CB  1 
ATOM   6807 C  CG  . ASP B 2 448 ? 155.595 185.561 123.259 1.00 85.33  ? 439 ASP A CG  1 
ATOM   6808 O  OD1 . ASP B 2 448 ? 154.535 185.038 122.858 1.00 87.21  ? 439 ASP A OD1 1 
ATOM   6809 O  OD2 . ASP B 2 448 ? 156.157 185.214 124.317 1.00 86.60  ? 439 ASP A OD2 1 
ATOM   6810 N  N   . PRO B 2 449 ? 156.260 189.417 121.095 1.00 86.64  ? 440 PRO A N   1 
ATOM   6811 C  CA  . PRO B 2 449 ? 157.096 190.439 120.448 1.00 91.57  ? 440 PRO A CA  1 
ATOM   6812 C  C   . PRO B 2 449 ? 158.532 189.992 120.226 1.00 90.25  ? 440 PRO A C   1 
ATOM   6813 O  O   . PRO B 2 449 ? 159.224 190.591 119.393 1.00 87.20  ? 440 PRO A O   1 
ATOM   6814 C  CB  . PRO B 2 449 ? 157.021 191.621 121.422 1.00 88.11  ? 440 PRO A CB  1 
ATOM   6815 C  CG  . PRO B 2 449 ? 155.720 191.438 122.113 1.00 84.77  ? 440 PRO A CG  1 
ATOM   6816 C  CD  . PRO B 2 449 ? 155.558 189.957 122.273 1.00 82.65  ? 440 PRO A CD  1 
ATOM   6817 N  N   . GLN B 2 450 ? 158.999 188.965 120.937 1.00 89.45  ? 441 GLN A N   1 
ATOM   6818 C  CA  . GLN B 2 450 ? 160.351 188.444 120.777 1.00 87.80  ? 441 GLN A CA  1 
ATOM   6819 C  C   . GLN B 2 450 ? 160.378 187.125 120.012 1.00 87.99  ? 441 GLN A C   1 
ATOM   6820 O  O   . GLN B 2 450 ? 161.349 186.370 120.121 1.00 90.41  ? 441 GLN A O   1 
ATOM   6821 C  CB  . GLN B 2 450 ? 161.022 188.283 122.141 1.00 87.99  ? 441 GLN A CB  1 
ATOM   6822 C  CG  . GLN B 2 450 ? 160.851 189.478 123.069 1.00 92.82  ? 441 GLN A CG  1 
ATOM   6823 C  CD  . GLN B 2 450 ? 161.477 190.750 122.522 1.00 100.84 ? 441 GLN A CD  1 
ATOM   6824 O  OE1 . GLN B 2 450 ? 160.947 191.379 121.606 1.00 100.73 ? 441 GLN A OE1 1 
ATOM   6825 N  NE2 . GLN B 2 450 ? 162.615 191.134 123.087 1.00 100.93 ? 441 GLN A NE2 1 
ATOM   6826 N  N   . GLY B 2 451 ? 159.338 186.829 119.241 1.00 84.18  ? 442 GLY A N   1 
ATOM   6827 C  CA  . GLY B 2 451 ? 159.341 185.632 118.418 1.00 78.79  ? 442 GLY A CA  1 
ATOM   6828 C  C   . GLY B 2 451 ? 159.346 184.317 119.166 1.00 77.54  ? 442 GLY A C   1 
ATOM   6829 O  O   . GLY B 2 451 ? 160.146 183.432 118.843 1.00 76.44  ? 442 GLY A O   1 
ATOM   6830 N  N   . ASP B 2 452 ? 158.485 184.168 120.166 1.00 79.96  ? 443 ASP A N   1 
ATOM   6831 C  CA  . ASP B 2 452 ? 158.337 182.917 120.893 1.00 78.89  ? 443 ASP A CA  1 
ATOM   6832 C  C   . ASP B 2 452 ? 156.873 182.511 120.919 1.00 78.36  ? 443 ASP A C   1 
ATOM   6833 O  O   . ASP B 2 452 ? 155.979 183.356 120.848 1.00 80.56  ? 443 ASP A O   1 
ATOM   6834 C  CB  . ASP B 2 452 ? 158.857 183.032 122.322 1.00 86.44  ? 443 ASP A CB  1 
ATOM   6835 C  CG  . ASP B 2 452 ? 160.348 182.838 122.412 1.00 88.73  ? 443 ASP A CG  1 
ATOM   6836 O  OD1 . ASP B 2 452 ? 160.977 183.459 123.292 1.00 92.15  ? 443 ASP A OD1 1 
ATOM   6837 O  OD2 . ASP B 2 452 ? 160.892 182.065 121.600 1.00 86.31  ? 443 ASP A OD2 1 
ATOM   6838 N  N   . VAL B 2 453 ? 156.634 181.211 121.030 1.00 73.57  ? 444 VAL A N   1 
ATOM   6839 C  CA  . VAL B 2 453 ? 155.289 180.664 121.135 1.00 73.15  ? 444 VAL A CA  1 
ATOM   6840 C  C   . VAL B 2 453 ? 155.074 180.195 122.564 1.00 77.02  ? 444 VAL A C   1 
ATOM   6841 O  O   . VAL B 2 453 ? 155.938 179.533 123.149 1.00 77.90  ? 444 VAL A O   1 
ATOM   6842 C  CB  . VAL B 2 453 ? 155.058 179.513 120.141 1.00 70.97  ? 444 VAL A CB  1 
ATOM   6843 C  CG1 . VAL B 2 453 ? 153.680 178.927 120.337 1.00 72.57  ? 444 VAL A CG1 1 
ATOM   6844 C  CG2 . VAL B 2 453 ? 155.214 180.006 118.728 1.00 68.95  ? 444 VAL A CG2 1 
ATOM   6845 N  N   . ALA B 2 454 ? 153.922 180.551 123.131 1.00 77.93  ? 445 ALA A N   1 
ATOM   6846 C  CA  . ALA B 2 454 ? 153.586 180.191 124.506 1.00 81.27  ? 445 ALA A CA  1 
ATOM   6847 C  C   . ALA B 2 454 ? 153.072 178.755 124.528 1.00 82.84  ? 445 ALA A C   1 
ATOM   6848 O  O   . ALA B 2 454 ? 151.869 178.484 124.513 1.00 88.32  ? 445 ALA A O   1 
ATOM   6849 C  CB  . ALA B 2 454 ? 152.565 181.163 125.080 1.00 82.30  ? 445 ALA A CB  1 
ATOM   6850 N  N   . LEU B 2 455 ? 154.013 177.818 124.563 1.00 77.72  ? 446 LEU A N   1 
ATOM   6851 C  CA  . LEU B 2 455 ? 153.715 176.397 124.672 1.00 74.70  ? 446 LEU A CA  1 
ATOM   6852 C  C   . LEU B 2 455 ? 154.087 175.919 126.067 1.00 74.30  ? 446 LEU A C   1 
ATOM   6853 O  O   . LEU B 2 455 ? 155.171 176.233 126.564 1.00 77.87  ? 446 LEU A O   1 
ATOM   6854 C  CB  . LEU B 2 455 ? 154.471 175.592 123.615 1.00 72.71  ? 446 LEU A CB  1 
ATOM   6855 C  CG  . LEU B 2 455 ? 153.834 175.548 122.227 1.00 72.18  ? 446 LEU A CG  1 
ATOM   6856 C  CD1 . LEU B 2 455 ? 154.487 174.481 121.379 1.00 68.29  ? 446 LEU A CD1 1 
ATOM   6857 C  CD2 . LEU B 2 455 ? 152.343 175.303 122.334 1.00 72.03  ? 446 LEU A CD2 1 
ATOM   6858 N  N   . HIS B 2 456 ? 153.189 175.172 126.697 1.00 73.33  ? 447 HIS A N   1 
ATOM   6859 C  CA  . HIS B 2 456 ? 153.428 174.716 128.057 1.00 70.65  ? 447 HIS A CA  1 
ATOM   6860 C  C   . HIS B 2 456 ? 154.573 173.714 128.096 1.00 68.97  ? 447 HIS A C   1 
ATOM   6861 O  O   . HIS B 2 456 ? 154.664 172.819 127.254 1.00 73.68  ? 447 HIS A O   1 
ATOM   6862 C  CB  . HIS B 2 456 ? 152.166 174.081 128.631 1.00 72.08  ? 447 HIS A CB  1 
ATOM   6863 C  CG  . HIS B 2 456 ? 150.911 174.805 128.266 1.00 80.61  ? 447 HIS A CG  1 
ATOM   6864 N  ND1 . HIS B 2 456 ? 149.721 174.155 128.027 1.00 84.88  ? 447 HIS A ND1 1 
ATOM   6865 C  CD2 . HIS B 2 456 ? 150.659 176.124 128.104 1.00 83.61  ? 447 HIS A CD2 1 
ATOM   6866 C  CE1 . HIS B 2 456 ? 148.789 175.042 127.732 1.00 90.43  ? 447 HIS A CE1 1 
ATOM   6867 N  NE2 . HIS B 2 456 ? 149.332 176.245 127.772 1.00 91.40  ? 447 HIS A NE2 1 
ATOM   6868 N  N   . LEU B 2 457 ? 155.452 173.872 129.078 1.00 64.36  ? 448 LEU A N   1 
ATOM   6869 C  CA  . LEU B 2 457 ? 156.486 172.886 129.330 1.00 63.43  ? 448 LEU A CA  1 
ATOM   6870 C  C   . LEU B 2 457 ? 155.927 171.777 130.214 1.00 68.85  ? 448 LEU A C   1 
ATOM   6871 O  O   . LEU B 2 457 ? 154.778 171.820 130.657 1.00 72.76  ? 448 LEU A O   1 
ATOM   6872 C  CB  . LEU B 2 457 ? 157.703 173.536 129.978 1.00 61.57  ? 448 LEU A CB  1 
ATOM   6873 C  CG  . LEU B 2 457 ? 158.551 174.449 129.104 1.00 61.22  ? 448 LEU A CG  1 
ATOM   6874 C  CD1 . LEU B 2 457 ? 159.731 174.949 129.899 1.00 63.84  ? 448 LEU A CD1 1 
ATOM   6875 C  CD2 . LEU B 2 457 ? 159.012 173.711 127.873 1.00 63.62  ? 448 LEU A CD2 1 
ATOM   6876 N  N   . GLU B 2 458 ? 156.753 170.774 130.491 1.00 68.88  ? 449 GLU A N   1 
ATOM   6877 C  CA  . GLU B 2 458 ? 156.312 169.630 131.275 1.00 64.38  ? 449 GLU A CA  1 
ATOM   6878 C  C   . GLU B 2 458 ? 157.526 168.926 131.848 1.00 62.81  ? 449 GLU A C   1 
ATOM   6879 O  O   . GLU B 2 458 ? 158.513 168.724 131.140 1.00 67.97  ? 449 GLU A O   1 
ATOM   6880 C  CB  . GLU B 2 458 ? 155.504 168.661 130.418 1.00 66.15  ? 449 GLU A CB  1 
ATOM   6881 C  CG  . GLU B 2 458 ? 154.029 168.687 130.701 1.00 73.66  ? 449 GLU A CG  1 
ATOM   6882 C  CD  . GLU B 2 458 ? 153.350 167.408 130.296 1.00 83.29  ? 449 GLU A CD  1 
ATOM   6883 O  OE1 . GLU B 2 458 ? 154.044 166.519 129.763 1.00 85.21  ? 449 GLU A OE1 1 
ATOM   6884 O  OE2 . GLU B 2 458 ? 152.125 167.289 130.506 1.00 87.57  ? 449 GLU A OE2 1 
ATOM   6885 N  N   . ILE B 2 459 ? 157.450 168.555 133.118 1.00 60.21  ? 450 ILE A N   1 
ATOM   6886 C  CA  . ILE B 2 459 ? 158.468 167.720 133.740 1.00 58.95  ? 450 ILE A CA  1 
ATOM   6887 C  C   . ILE B 2 459 ? 158.056 166.266 133.590 1.00 61.05  ? 450 ILE A C   1 
ATOM   6888 O  O   . ILE B 2 459 ? 156.956 165.878 133.994 1.00 66.23  ? 450 ILE A O   1 
ATOM   6889 C  CB  . ILE B 2 459 ? 158.664 168.086 135.218 1.00 58.49  ? 450 ILE A CB  1 
ATOM   6890 C  CG1 . ILE B 2 459 ? 159.164 169.521 135.351 1.00 60.95  ? 450 ILE A CG1 1 
ATOM   6891 C  CG2 . ILE B 2 459 ? 159.617 167.114 135.873 1.00 57.24  ? 450 ILE A CG2 1 
ATOM   6892 C  CD1 . ILE B 2 459 ? 158.102 170.496 135.743 1.00 66.42  ? 450 ILE A CD1 1 
ATOM   6893 N  N   . VAL B 2 460 ? 158.936 165.459 133.008 1.00 59.97  ? 451 VAL A N   1 
ATOM   6894 C  CA  . VAL B 2 460 ? 158.665 164.054 132.745 1.00 61.80  ? 451 VAL A CA  1 
ATOM   6895 C  C   . VAL B 2 460 ? 159.566 163.219 133.639 1.00 62.53  ? 451 VAL A C   1 
ATOM   6896 O  O   . VAL B 2 460 ? 160.724 163.580 133.874 1.00 66.77  ? 451 VAL A O   1 
ATOM   6897 C  CB  . VAL B 2 460 ? 158.862 163.702 131.259 1.00 62.84  ? 451 VAL A CB  1 
ATOM   6898 C  CG1 . VAL B 2 460 ? 158.253 164.774 130.389 1.00 66.45  ? 451 VAL A CG1 1 
ATOM   6899 C  CG2 . VAL B 2 460 ? 160.328 163.532 130.915 1.00 60.40  ? 451 VAL A CG2 1 
ATOM   6900 N  N   . GLN B 2 461 ? 159.021 162.137 134.175 1.00 60.40  ? 452 GLN A N   1 
ATOM   6901 C  CA  . GLN B 2 461 ? 159.782 161.203 134.987 1.00 58.54  ? 452 GLN A CA  1 
ATOM   6902 C  C   . GLN B 2 461 ? 159.955 159.910 134.212 1.00 67.03  ? 452 GLN A C   1 
ATOM   6903 O  O   . GLN B 2 461 ? 158.969 159.289 133.808 1.00 77.65  ? 452 GLN A O   1 
ATOM   6904 C  CB  . GLN B 2 461 ? 159.079 160.928 136.314 1.00 61.84  ? 452 GLN A CB  1 
ATOM   6905 C  CG  . GLN B 2 461 ? 159.897 160.089 137.269 1.00 68.41  ? 452 GLN A CG  1 
ATOM   6906 C  CD  . GLN B 2 461 ? 159.095 158.977 137.898 1.00 73.98  ? 452 GLN A CD  1 
ATOM   6907 O  OE1 . GLN B 2 461 ? 157.879 158.905 137.736 1.00 78.14  ? 452 GLN A OE1 1 
ATOM   6908 N  NE2 . GLN B 2 461 ? 159.773 158.100 138.626 1.00 67.80  ? 452 GLN A NE2 1 
ATOM   6909 N  N   . TRP B 2 462 ? 161.201 159.504 134.010 1.00 65.54  ? 453 TRP A N   1 
ATOM   6910 C  CA  . TRP B 2 462 ? 161.473 158.306 133.233 1.00 68.86  ? 453 TRP A CA  1 
ATOM   6911 C  C   . TRP B 2 462 ? 161.010 157.085 134.009 1.00 77.02  ? 453 TRP A C   1 
ATOM   6912 O  O   . TRP B 2 462 ? 161.543 156.790 135.082 1.00 81.40  ? 453 TRP A O   1 
ATOM   6913 C  CB  . TRP B 2 462 ? 162.961 158.196 132.927 1.00 69.24  ? 453 TRP A CB  1 
ATOM   6914 C  CG  . TRP B 2 462 ? 163.500 159.269 132.053 1.00 67.22  ? 453 TRP A CG  1 
ATOM   6915 C  CD1 . TRP B 2 462 ? 162.859 160.391 131.638 1.00 67.78  ? 453 TRP A CD1 1 
ATOM   6916 C  CD2 . TRP B 2 462 ? 164.807 159.320 131.483 1.00 66.83  ? 453 TRP A CD2 1 
ATOM   6917 N  NE1 . TRP B 2 462 ? 163.685 161.142 130.844 1.00 64.83  ? 453 TRP A NE1 1 
ATOM   6918 C  CE2 . TRP B 2 462 ? 164.889 160.502 130.734 1.00 65.70  ? 453 TRP A CE2 1 
ATOM   6919 C  CE3 . TRP B 2 462 ? 165.918 158.477 131.533 1.00 72.92  ? 453 TRP A CE3 1 
ATOM   6920 C  CZ2 . TRP B 2 462 ? 166.033 160.862 130.041 1.00 70.38  ? 453 TRP A CZ2 1 
ATOM   6921 C  CZ3 . TRP B 2 462 ? 167.051 158.838 130.846 1.00 76.01  ? 453 TRP A CZ3 1 
ATOM   6922 C  CH2 . TRP B 2 462 ? 167.101 160.017 130.109 1.00 73.28  ? 453 TRP A CH2 1 
ATOM   6923 N  N   . GLN B 2 463 ? 160.022 156.375 133.477 1.00 77.03  ? 454 GLN A N   1 
ATOM   6924 C  CA  . GLN B 2 463 ? 159.582 155.111 134.049 1.00 79.66  ? 454 GLN A CA  1 
ATOM   6925 C  C   . GLN B 2 463 ? 159.797 154.014 133.020 1.00 86.22  ? 454 GLN A C   1 
ATOM   6926 O  O   . GLN B 2 463 ? 159.459 154.184 131.845 1.00 89.01  ? 454 GLN A O   1 
ATOM   6927 C  CB  . GLN B 2 463 ? 158.120 155.172 134.492 1.00 75.98  ? 454 GLN A CB  1 
ATOM   6928 C  CG  . GLN B 2 463 ? 157.131 155.529 133.408 1.00 81.28  ? 454 GLN A CG  1 
ATOM   6929 C  CD  . GLN B 2 463 ? 156.147 154.409 133.144 1.00 92.34  ? 454 GLN A CD  1 
ATOM   6930 O  OE1 . GLN B 2 463 ? 156.321 153.291 133.626 1.00 94.21  ? 454 GLN A OE1 1 
ATOM   6931 N  NE2 . GLN B 2 463 ? 155.097 154.708 132.393 1.00 96.00  ? 454 GLN A NE2 1 
ATOM   6932 N  N   . TRP B 2 464 ? 160.376 152.901 133.458 1.00 87.28  ? 455 TRP A N   1 
ATOM   6933 C  CA  . TRP B 2 464 ? 160.808 151.833 132.562 1.00 87.44  ? 455 TRP A CA  1 
ATOM   6934 C  C   . TRP B 2 464 ? 159.714 150.776 132.487 1.00 91.60  ? 455 TRP A C   1 
ATOM   6935 O  O   . TRP B 2 464 ? 159.631 149.888 133.338 1.00 90.86  ? 455 TRP A O   1 
ATOM   6936 C  CB  . TRP B 2 464 ? 162.126 151.236 133.037 1.00 87.85  ? 455 TRP A CB  1 
ATOM   6937 C  CG  . TRP B 2 464 ? 163.299 152.091 132.713 1.00 87.36  ? 455 TRP A CG  1 
ATOM   6938 C  CD1 . TRP B 2 464 ? 164.111 151.987 131.627 1.00 88.97  ? 455 TRP A CD1 1 
ATOM   6939 C  CD2 . TRP B 2 464 ? 163.799 153.185 133.486 1.00 84.33  ? 455 TRP A CD2 1 
ATOM   6940 N  NE1 . TRP B 2 464 ? 165.086 152.951 131.673 1.00 89.12  ? 455 TRP A NE1 1 
ATOM   6941 C  CE2 . TRP B 2 464 ? 164.914 153.700 132.806 1.00 82.59  ? 455 TRP A CE2 1 
ATOM   6942 C  CE3 . TRP B 2 464 ? 163.409 153.779 134.687 1.00 83.79  ? 455 TRP A CE3 1 
ATOM   6943 C  CZ2 . TRP B 2 464 ? 165.644 154.779 133.285 1.00 76.39  ? 455 TRP A CZ2 1 
ATOM   6944 C  CZ3 . TRP B 2 464 ? 164.134 154.850 135.160 1.00 82.76  ? 455 TRP A CZ3 1 
ATOM   6945 C  CH2 . TRP B 2 464 ? 165.239 155.340 134.461 1.00 77.43  ? 455 TRP A CH2 1 
ATOM   6946 N  N   . ASP B 2 465 ? 158.876 150.875 131.461 1.00 94.80  ? 456 ASP A N   1 
ATOM   6947 C  CA  . ASP B 2 465 ? 157.853 149.870 131.194 1.00 99.97  ? 456 ASP A CA  1 
ATOM   6948 C  C   . ASP B 2 465 ? 157.533 149.936 129.710 1.00 104.84 ? 456 ASP A C   1 
ATOM   6949 O  O   . ASP B 2 465 ? 156.847 150.860 129.266 1.00 103.28 ? 456 ASP A O   1 
ATOM   6950 C  CB  . ASP B 2 465 ? 156.607 150.108 132.038 1.00 100.83 ? 456 ASP A CB  1 
ATOM   6951 C  CG  . ASP B 2 465 ? 155.674 148.919 132.038 1.00 103.76 ? 456 ASP A CG  1 
ATOM   6952 O  OD1 . ASP B 2 465 ? 156.121 147.815 131.667 1.00 99.55  ? 456 ASP A OD1 1 
ATOM   6953 O  OD2 . ASP B 2 465 ? 154.493 149.090 132.403 1.00 106.05 ? 456 ASP A OD2 1 
ATOM   6954 N  N   . ARG B 2 466 ? 158.027 148.958 128.948 1.00 107.15 ? 457 ARG A N   1 
ATOM   6955 C  CA  . ARG B 2 466 ? 157.887 148.995 127.497 1.00 108.39 ? 457 ARG A CA  1 
ATOM   6956 C  C   . ARG B 2 466 ? 156.434 148.937 127.044 1.00 103.21 ? 457 ARG A C   1 
ATOM   6957 O  O   . ARG B 2 466 ? 156.136 149.336 125.914 1.00 97.70  ? 457 ARG A O   1 
ATOM   6958 C  CB  . ARG B 2 466 ? 158.677 147.847 126.869 1.00 111.32 ? 457 ARG A CB  1 
ATOM   6959 C  CG  . ARG B 2 466 ? 159.852 147.372 127.708 1.00 108.94 ? 457 ARG A CG  1 
ATOM   6960 C  CD  . ARG B 2 466 ? 160.958 146.805 126.834 1.00 112.48 ? 457 ARG A CD  1 
ATOM   6961 N  NE  . ARG B 2 466 ? 161.585 147.826 126.003 1.00 116.22 ? 457 ARG A NE  1 
ATOM   6962 C  CZ  . ARG B 2 466 ? 162.553 148.636 126.411 1.00 118.13 ? 457 ARG A CZ  1 
ATOM   6963 N  NH1 . ARG B 2 466 ? 163.033 148.574 127.642 1.00 116.31 ? 457 ARG A NH1 1 
ATOM   6964 N  NH2 . ARG B 2 466 ? 163.053 149.528 125.561 1.00 119.96 ? 457 ARG A NH2 1 
ATOM   6965 N  N   . SER B 2 467 ? 155.528 148.448 127.888 1.00 103.53 ? 458 SER A N   1 
ATOM   6966 C  CA  . SER B 2 467 ? 154.116 148.419 127.535 1.00 104.71 ? 458 SER A CA  1 
ATOM   6967 C  C   . SER B 2 467 ? 153.428 149.759 127.755 1.00 107.46 ? 458 SER A C   1 
ATOM   6968 O  O   . SER B 2 467 ? 152.336 149.975 127.219 1.00 108.88 ? 458 SER A O   1 
ATOM   6969 C  CB  . SER B 2 467 ? 153.403 147.328 128.337 1.00 107.38 ? 458 SER A CB  1 
ATOM   6970 O  OG  . SER B 2 467 ? 152.072 147.697 128.648 1.00 110.84 ? 458 SER A OG  1 
ATOM   6971 N  N   . GLN B 2 468 ? 154.043 150.665 128.508 1.00 106.83 ? 459 GLN A N   1 
ATOM   6972 C  CA  . GLN B 2 468 ? 153.456 151.959 128.830 1.00 103.30 ? 459 GLN A CA  1 
ATOM   6973 C  C   . GLN B 2 468 ? 154.345 153.081 128.298 1.00 97.23  ? 459 GLN A C   1 
ATOM   6974 O  O   . GLN B 2 468 ? 155.334 152.846 127.599 1.00 98.46  ? 459 GLN A O   1 
ATOM   6975 C  CB  . GLN B 2 468 ? 153.239 152.090 130.339 1.00 100.35 ? 459 GLN A CB  1 
ATOM   6976 C  CG  . GLN B 2 468 ? 152.195 151.147 130.896 1.00 103.55 ? 459 GLN A CG  1 
ATOM   6977 C  CD  . GLN B 2 468 ? 152.035 151.286 132.392 1.00 106.20 ? 459 GLN A CD  1 
ATOM   6978 O  OE1 . GLN B 2 468 ? 152.106 152.387 132.936 1.00 103.32 ? 459 GLN A OE1 1 
ATOM   6979 N  NE2 . GLN B 2 468 ? 151.818 150.167 133.070 1.00 110.10 ? 459 GLN A NE2 1 
ATOM   6980 N  N   . ASN B 2 469 ? 153.982 154.307 128.642 1.00 92.65  ? 460 ASN A N   1 
ATOM   6981 C  CA  . ASN B 2 469 ? 154.697 155.481 128.163 1.00 91.60  ? 460 ASN A CA  1 
ATOM   6982 C  C   . ASN B 2 469 ? 156.105 155.509 128.740 1.00 87.37  ? 460 ASN A C   1 
ATOM   6983 O  O   . ASN B 2 469 ? 156.259 155.488 129.966 1.00 89.33  ? 460 ASN A O   1 
ATOM   6984 C  CB  . ASN B 2 469 ? 153.933 156.739 128.558 1.00 89.78  ? 460 ASN A CB  1 
ATOM   6985 C  CG  . ASN B 2 469 ? 154.348 157.954 127.756 1.00 91.87  ? 460 ASN A CG  1 
ATOM   6986 O  OD1 . ASN B 2 469 ? 155.480 158.048 127.285 1.00 88.50  ? 460 ASN A OD1 1 
ATOM   6987 N  ND2 . ASN B 2 469 ? 153.428 158.900 127.603 1.00 94.13  ? 460 ASN A ND2 1 
ATOM   6988 N  N   . PRO B 2 470 ? 157.152 155.547 127.914 1.00 83.45  ? 461 PRO A N   1 
ATOM   6989 C  CA  . PRO B 2 470 ? 158.511 155.633 128.465 1.00 80.72  ? 461 PRO A CA  1 
ATOM   6990 C  C   . PRO B 2 470 ? 158.798 156.944 129.164 1.00 83.70  ? 461 PRO A C   1 
ATOM   6991 O  O   . PRO B 2 470 ? 159.722 156.996 129.983 1.00 84.98  ? 461 PRO A O   1 
ATOM   6992 C  CB  . PRO B 2 470 ? 159.403 155.456 127.232 1.00 81.95  ? 461 PRO A CB  1 
ATOM   6993 C  CG  . PRO B 2 470 ? 158.560 155.912 126.102 1.00 87.32  ? 461 PRO A CG  1 
ATOM   6994 C  CD  . PRO B 2 470 ? 157.157 155.510 126.444 1.00 88.09  ? 461 PRO A CD  1 
ATOM   6995 N  N   . PHE B 2 471 ? 158.046 158.002 128.873 1.00 80.63  ? 462 PHE A N   1 
ATOM   6996 C  CA  . PHE B 2 471 ? 158.231 159.310 129.495 1.00 77.43  ? 462 PHE A CA  1 
ATOM   6997 C  C   . PHE B 2 471 ? 156.898 159.715 130.110 1.00 78.33  ? 462 PHE A C   1 
ATOM   6998 O  O   . PHE B 2 471 ? 156.100 160.412 129.481 1.00 82.72  ? 462 PHE A O   1 
ATOM   6999 C  CB  . PHE B 2 471 ? 158.703 160.342 128.485 1.00 72.25  ? 462 PHE A CB  1 
ATOM   7000 C  CG  . PHE B 2 471 ? 160.019 160.017 127.861 1.00 72.49  ? 462 PHE A CG  1 
ATOM   7001 C  CD1 . PHE B 2 471 ? 161.032 159.458 128.605 1.00 74.01  ? 462 PHE A CD1 1 
ATOM   7002 C  CD2 . PHE B 2 471 ? 160.239 160.261 126.523 1.00 76.65  ? 462 PHE A CD2 1 
ATOM   7003 C  CE1 . PHE B 2 471 ? 162.242 159.153 128.027 1.00 75.38  ? 462 PHE A CE1 1 
ATOM   7004 C  CE2 . PHE B 2 471 ? 161.447 159.955 125.941 1.00 76.81  ? 462 PHE A CE2 1 
ATOM   7005 C  CZ  . PHE B 2 471 ? 162.449 159.403 126.695 1.00 73.82  ? 462 PHE A CZ  1 
ATOM   7006 N  N   . GLN B 2 472 ? 156.656 159.278 131.338 1.00 76.11  ? 463 GLN A N   1 
ATOM   7007 C  CA  . GLN B 2 472 ? 155.454 159.676 132.050 1.00 76.02  ? 463 GLN A CA  1 
ATOM   7008 C  C   . GLN B 2 472 ? 155.549 161.149 132.416 1.00 71.85  ? 463 GLN A C   1 
ATOM   7009 O  O   . GLN B 2 472 ? 156.621 161.644 132.764 1.00 71.08  ? 463 GLN A O   1 
ATOM   7010 C  CB  . GLN B 2 472 ? 155.271 158.822 133.303 1.00 81.80  ? 463 GLN A CB  1 
ATOM   7011 C  CG  . GLN B 2 472 ? 153.990 159.093 134.065 1.00 85.56  ? 463 GLN A CG  1 
ATOM   7012 C  CD  . GLN B 2 472 ? 152.828 158.269 133.553 1.00 87.70  ? 463 GLN A CD  1 
ATOM   7013 O  OE1 . GLN B 2 472 ? 153.016 157.179 133.016 1.00 92.43  ? 463 GLN A OE1 1 
ATOM   7014 N  NE2 . GLN B 2 472 ? 151.617 158.789 133.714 1.00 80.77  ? 463 GLN A NE2 1 
ATOM   7015 N  N   . SER B 2 473 ? 154.428 161.853 132.320 1.00 68.37  ? 464 SER A N   1 
ATOM   7016 C  CA  . SER B 2 473 ? 154.373 163.275 132.629 1.00 69.42  ? 464 SER A CA  1 
ATOM   7017 C  C   . SER B 2 473 ? 153.832 163.473 134.037 1.00 72.69  ? 464 SER A C   1 
ATOM   7018 O  O   . SER B 2 473 ? 152.817 162.874 134.402 1.00 76.56  ? 464 SER A O   1 
ATOM   7019 C  CB  . SER B 2 473 ? 153.494 164.013 131.625 1.00 74.61  ? 464 SER A CB  1 
ATOM   7020 O  OG  . SER B 2 473 ? 152.855 165.111 132.246 1.00 80.93  ? 464 SER A OG  1 
ATOM   7021 N  N   . VAL B 2 474 ? 154.501 164.316 134.819 1.00 71.22  ? 465 VAL A N   1 
ATOM   7022 C  CA  . VAL B 2 474 ? 154.122 164.517 136.211 1.00 73.29  ? 465 VAL A CA  1 
ATOM   7023 C  C   . VAL B 2 474 ? 153.739 165.954 136.535 1.00 71.67  ? 465 VAL A C   1 
ATOM   7024 O  O   . VAL B 2 474 ? 152.973 166.171 137.487 1.00 75.73  ? 465 VAL A O   1 
ATOM   7025 C  CB  . VAL B 2 474 ? 155.235 164.043 137.167 1.00 69.19  ? 465 VAL A CB  1 
ATOM   7026 C  CG1 . VAL B 2 474 ? 155.561 162.588 136.913 1.00 69.74  ? 465 VAL A CG1 1 
ATOM   7027 C  CG2 . VAL B 2 474 ? 156.466 164.906 137.020 1.00 64.55  ? 465 VAL A CG2 1 
ATOM   7028 N  N   . ALA B 2 475 ? 154.222 166.951 135.802 1.00 63.56  ? 466 ALA A N   1 
ATOM   7029 C  CA  . ALA B 2 475 ? 153.904 168.329 136.134 1.00 63.35  ? 466 ALA A CA  1 
ATOM   7030 C  C   . ALA B 2 475 ? 153.816 169.146 134.858 1.00 68.83  ? 466 ALA A C   1 
ATOM   7031 O  O   . ALA B 2 475 ? 154.488 168.848 133.869 1.00 74.63  ? 466 ALA A O   1 
ATOM   7032 C  CB  . ALA B 2 475 ? 154.946 168.932 137.075 1.00 65.42  ? 466 ALA A CB  1 
ATOM   7033 N  N   . SER B 2 476 ? 152.991 170.187 134.894 1.00 72.02  ? 467 SER A N   1 
ATOM   7034 C  CA  . SER B 2 476 ? 152.765 171.061 133.752 1.00 71.29  ? 467 SER A CA  1 
ATOM   7035 C  C   . SER B 2 476 ? 153.135 172.483 134.135 1.00 70.23  ? 467 SER A C   1 
ATOM   7036 O  O   . SER B 2 476 ? 152.733 172.965 135.197 1.00 78.99  ? 467 SER A O   1 
ATOM   7037 C  CB  . SER B 2 476 ? 151.308 171.002 133.297 1.00 72.38  ? 467 SER A CB  1 
ATOM   7038 O  OG  . SER B 2 476 ? 150.899 169.664 133.086 1.00 72.47  ? 467 SER A OG  1 
ATOM   7039 N  N   . TYR B 2 477 ? 153.892 173.152 133.274 1.00 63.25  ? 468 TYR A N   1 
ATOM   7040 C  CA  . TYR B 2 477 ? 154.350 174.509 133.526 1.00 66.50  ? 468 TYR A CA  1 
ATOM   7041 C  C   . TYR B 2 477 ? 153.768 175.435 132.472 1.00 71.51  ? 468 TYR A C   1 
ATOM   7042 O  O   . TYR B 2 477 ? 153.863 175.152 131.275 1.00 76.98  ? 468 TYR A O   1 
ATOM   7043 C  CB  . TYR B 2 477 ? 155.873 174.578 133.511 1.00 66.17  ? 468 TYR A CB  1 
ATOM   7044 C  CG  . TYR B 2 477 ? 156.422 175.978 133.555 1.00 65.79  ? 468 TYR A CG  1 
ATOM   7045 C  CD1 . TYR B 2 477 ? 156.292 176.753 134.693 1.00 74.02  ? 468 TYR A CD1 1 
ATOM   7046 C  CD2 . TYR B 2 477 ? 157.082 176.520 132.469 1.00 62.72  ? 468 TYR A CD2 1 
ATOM   7047 C  CE1 . TYR B 2 477 ? 156.795 178.029 134.745 1.00 75.45  ? 468 TYR A CE1 1 
ATOM   7048 C  CE2 . TYR B 2 477 ? 157.590 177.794 132.511 1.00 64.95  ? 468 TYR A CE2 1 
ATOM   7049 C  CZ  . TYR B 2 477 ? 157.442 178.544 133.652 1.00 72.65  ? 468 TYR A CZ  1 
ATOM   7050 O  OH  . TYR B 2 477 ? 157.945 179.819 133.703 1.00 79.94  ? 468 TYR A OH  1 
ATOM   7051 N  N   . TYR B 2 478 ? 153.174 176.542 132.913 1.00 71.83  ? 469 TYR A N   1 
ATOM   7052 C  CA  . TYR B 2 478 ? 152.550 177.485 131.998 1.00 74.33  ? 469 TYR A CA  1 
ATOM   7053 C  C   . TYR B 2 478 ? 153.434 178.711 131.855 1.00 75.94  ? 469 TYR A C   1 
ATOM   7054 O  O   . TYR B 2 478 ? 153.522 179.510 132.798 1.00 78.57  ? 469 TYR A O   1 
ATOM   7055 C  CB  . TYR B 2 478 ? 151.168 177.883 132.503 1.00 73.97  ? 469 TYR A CB  1 
ATOM   7056 C  CG  . TYR B 2 478 ? 150.221 176.722 132.645 1.00 75.94  ? 469 TYR A CG  1 
ATOM   7057 C  CD1 . TYR B 2 478 ? 149.534 176.227 131.550 1.00 79.54  ? 469 TYR A CD1 1 
ATOM   7058 C  CD2 . TYR B 2 478 ? 150.017 176.118 133.872 1.00 75.56  ? 469 TYR A CD2 1 
ATOM   7059 C  CE1 . TYR B 2 478 ? 148.666 175.165 131.675 1.00 83.38  ? 469 TYR A CE1 1 
ATOM   7060 C  CE2 . TYR B 2 478 ? 149.153 175.056 134.006 1.00 78.50  ? 469 TYR A CE2 1 
ATOM   7061 C  CZ  . TYR B 2 478 ? 148.480 174.582 132.906 1.00 85.21  ? 469 TYR A CZ  1 
ATOM   7062 O  OH  . TYR B 2 478 ? 147.616 173.521 133.040 1.00 89.23  ? 469 TYR A OH  1 
ATOM   7063 N  N   . PRO B 2 479 ? 154.093 178.914 130.713 1.00 72.76  ? 470 PRO A N   1 
ATOM   7064 C  CA  . PRO B 2 479 ? 155.028 180.042 130.601 1.00 71.32  ? 470 PRO A CA  1 
ATOM   7065 C  C   . PRO B 2 479 ? 154.372 181.398 130.749 1.00 78.48  ? 470 PRO A C   1 
ATOM   7066 O  O   . PRO B 2 479 ? 155.049 182.358 131.134 1.00 81.97  ? 470 PRO A O   1 
ATOM   7067 C  CB  . PRO B 2 479 ? 155.624 179.864 129.198 1.00 70.33  ? 470 PRO A CB  1 
ATOM   7068 C  CG  . PRO B 2 479 ? 155.328 178.465 128.819 1.00 72.81  ? 470 PRO A CG  1 
ATOM   7069 C  CD  . PRO B 2 479 ? 154.040 178.120 129.479 1.00 75.73  ? 470 PRO A CD  1 
ATOM   7070 N  N   . LEU B 2 480 ? 153.078 181.511 130.448 1.00 79.63  ? 471 LEU A N   1 
ATOM   7071 C  CA  . LEU B 2 480 ? 152.434 182.821 130.437 1.00 84.09  ? 471 LEU A CA  1 
ATOM   7072 C  C   . LEU B 2 480 ? 152.433 183.457 131.821 1.00 86.94  ? 471 LEU A C   1 
ATOM   7073 O  O   . LEU B 2 480 ? 152.711 184.653 131.962 1.00 87.20  ? 471 LEU A O   1 
ATOM   7074 C  CB  . LEU B 2 480 ? 151.013 182.695 129.896 1.00 81.23  ? 471 LEU A CB  1 
ATOM   7075 C  CG  . LEU B 2 480 ? 150.939 182.591 128.374 1.00 84.37  ? 471 LEU A CG  1 
ATOM   7076 C  CD1 . LEU B 2 480 ? 149.518 182.789 127.886 1.00 89.98  ? 471 LEU A CD1 1 
ATOM   7077 C  CD2 . LEU B 2 480 ? 151.868 183.606 127.736 1.00 82.17  ? 471 LEU A CD2 1 
ATOM   7078 N  N   . GLN B 2 481 ? 152.127 182.678 132.854 1.00 86.72  ? 472 GLN A N   1 
ATOM   7079 C  CA  . GLN B 2 481 ? 152.151 183.174 134.222 1.00 86.08  ? 472 GLN A CA  1 
ATOM   7080 C  C   . GLN B 2 481 ? 153.384 182.726 134.991 1.00 84.14  ? 472 GLN A C   1 
ATOM   7081 O  O   . GLN B 2 481 ? 153.539 183.103 136.156 1.00 85.11  ? 472 GLN A O   1 
ATOM   7082 C  CB  . GLN B 2 481 ? 150.889 182.733 134.968 1.00 84.11  ? 472 GLN A CB  1 
ATOM   7083 C  CG  . GLN B 2 481 ? 150.603 181.253 134.877 1.00 82.69  ? 472 GLN A CG  1 
ATOM   7084 C  CD  . GLN B 2 481 ? 149.134 180.942 135.036 1.00 86.78  ? 472 GLN A CD  1 
ATOM   7085 O  OE1 . GLN B 2 481 ? 148.690 180.530 136.104 1.00 91.05  ? 472 GLN A OE1 1 
ATOM   7086 N  NE2 . GLN B 2 481 ? 148.369 181.139 133.971 1.00 85.20  ? 472 GLN A NE2 1 
ATOM   7087 N  N   . ARG B 2 482 ? 154.264 181.944 134.366 1.00 82.14  ? 473 ARG A N   1 
ATOM   7088 C  CA  . ARG B 2 482 ? 155.487 181.462 135.004 1.00 80.18  ? 473 ARG A CA  1 
ATOM   7089 C  C   . ARG B 2 482 ? 155.182 180.734 136.308 1.00 82.77  ? 473 ARG A C   1 
ATOM   7090 O  O   . ARG B 2 482 ? 155.843 180.937 137.327 1.00 85.20  ? 473 ARG A O   1 
ATOM   7091 C  CB  . ARG B 2 482 ? 156.471 182.606 135.236 1.00 79.88  ? 473 ARG A CB  1 
ATOM   7092 C  CG  . ARG B 2 482 ? 157.017 183.210 133.959 1.00 84.01  ? 473 ARG A CG  1 
ATOM   7093 C  CD  . ARG B 2 482 ? 157.975 184.342 134.261 1.00 84.63  ? 473 ARG A CD  1 
ATOM   7094 N  NE  . ARG B 2 482 ? 159.282 183.838 134.659 1.00 78.61  ? 473 ARG A NE  1 
ATOM   7095 C  CZ  . ARG B 2 482 ? 160.399 184.040 133.976 1.00 75.42  ? 473 ARG A CZ  1 
ATOM   7096 N  NH1 . ARG B 2 482 ? 160.407 184.751 132.862 1.00 74.70  ? 473 ARG A NH1 1 
ATOM   7097 N  NH2 . ARG B 2 482 ? 161.535 183.514 134.422 1.00 76.15  ? 473 ARG A NH2 1 
ATOM   7098 N  N   . GLN B 2 483 ? 154.162 179.882 136.279 1.00 83.28  ? 474 GLN A N   1 
ATOM   7099 C  CA  . GLN B 2 483 ? 153.741 179.125 137.448 1.00 82.15  ? 474 GLN A CA  1 
ATOM   7100 C  C   . GLN B 2 483 ? 153.688 177.649 137.095 1.00 76.30  ? 474 GLN A C   1 
ATOM   7101 O  O   . GLN B 2 483 ? 153.097 177.274 136.080 1.00 78.39  ? 474 GLN A O   1 
ATOM   7102 C  CB  . GLN B 2 483 ? 152.373 179.601 137.944 1.00 81.59  ? 474 GLN A CB  1 
ATOM   7103 C  CG  . GLN B 2 483 ? 151.923 178.972 139.249 1.00 82.89  ? 474 GLN A CG  1 
ATOM   7104 C  CD  . GLN B 2 483 ? 152.784 179.391 140.422 1.00 86.82  ? 474 GLN A CD  1 
ATOM   7105 O  OE1 . GLN B 2 483 ? 153.375 180.471 140.417 1.00 85.01  ? 474 GLN A OE1 1 
ATOM   7106 N  NE2 . GLN B 2 483 ? 152.852 178.542 141.439 1.00 86.14  ? 474 GLN A NE2 1 
ATOM   7107 N  N   . LEU B 2 484 ? 154.297 176.817 137.931 1.00 72.58  ? 475 LEU A N   1 
ATOM   7108 C  CA  . LEU B 2 484 ? 154.267 175.372 137.757 1.00 75.16  ? 475 LEU A CA  1 
ATOM   7109 C  C   . LEU B 2 484 ? 153.206 174.786 138.675 1.00 78.84  ? 475 LEU A C   1 
ATOM   7110 O  O   . LEU B 2 484 ? 153.217 175.042 139.882 1.00 80.85  ? 475 LEU A O   1 
ATOM   7111 C  CB  . LEU B 2 484 ? 155.630 174.754 138.063 1.00 74.19  ? 475 LEU A CB  1 
ATOM   7112 C  CG  . LEU B 2 484 ? 155.623 173.244 138.296 1.00 70.11  ? 475 LEU A CG  1 
ATOM   7113 C  CD1 . LEU B 2 484 ? 155.456 172.528 136.981 1.00 68.13  ? 475 LEU A CD1 1 
ATOM   7114 C  CD2 . LEU B 2 484 ? 156.896 172.796 138.987 1.00 66.13  ? 475 LEU A CD2 1 
ATOM   7115 N  N   . LYS B 2 485 ? 152.296 174.002 138.107 1.00 75.16  ? 476 LYS A N   1 
ATOM   7116 C  CA  . LYS B 2 485 ? 151.162 173.502 138.866 1.00 72.81  ? 476 LYS A CA  1 
ATOM   7117 C  C   . LYS B 2 485 ? 150.798 172.109 138.374 1.00 71.13  ? 476 LYS A C   1 
ATOM   7118 O  O   . LYS B 2 485 ? 151.392 171.584 137.431 1.00 70.88  ? 476 LYS A O   1 
ATOM   7119 C  CB  . LYS B 2 485 ? 149.969 174.452 138.755 1.00 76.94  ? 476 LYS A CB  1 
ATOM   7120 C  CG  . LYS B 2 485 ? 149.830 175.112 137.398 1.00 76.40  ? 476 LYS A CG  1 
ATOM   7121 C  CD  . LYS B 2 485 ? 148.542 175.911 137.308 1.00 79.43  ? 476 LYS A CD  1 
ATOM   7122 C  CE  . LYS B 2 485 ? 148.590 177.149 138.184 1.00 81.19  ? 476 LYS A CE  1 
ATOM   7123 N  NZ  . LYS B 2 485 ? 147.796 178.263 137.600 1.00 81.79  ? 476 LYS A NZ  1 
ATOM   7124 N  N   . ASN B 2 486 ? 149.801 171.520 139.031 1.00 75.08  ? 477 ASN A N   1 
ATOM   7125 C  CA  . ASN B 2 486 ? 149.287 170.193 138.698 1.00 78.06  ? 477 ASN A CA  1 
ATOM   7126 C  C   . ASN B 2 486 ? 150.363 169.119 138.821 1.00 78.72  ? 477 ASN A C   1 
ATOM   7127 O  O   . ASN B 2 486 ? 150.493 168.246 137.961 1.00 78.99  ? 477 ASN A O   1 
ATOM   7128 C  CB  . ASN B 2 486 ? 148.664 170.177 137.303 1.00 75.40  ? 477 ASN A CB  1 
ATOM   7129 C  CG  . ASN B 2 486 ? 147.207 169.784 137.328 1.00 81.63  ? 477 ASN A CG  1 
ATOM   7130 O  OD1 . ASN B 2 486 ? 146.546 169.882 138.360 1.00 83.06  ? 477 ASN A OD1 1 
ATOM   7131 N  ND2 . ASN B 2 486 ? 146.696 169.333 136.191 1.00 84.03  ? 477 ASN A ND2 1 
ATOM   7132 N  N   . ILE B 2 487 ? 151.133 169.169 139.903 1.00 73.12  ? 478 ILE A N   1 
ATOM   7133 C  CA  . ILE B 2 487 ? 152.129 168.139 140.170 1.00 70.19  ? 478 ILE A CA  1 
ATOM   7134 C  C   . ILE B 2 487 ? 151.422 166.889 140.669 1.00 74.90  ? 478 ILE A C   1 
ATOM   7135 O  O   . ILE B 2 487 ? 150.632 166.946 141.618 1.00 75.12  ? 478 ILE A O   1 
ATOM   7136 C  CB  . ILE B 2 487 ? 153.169 168.628 141.186 1.00 70.44  ? 478 ILE A CB  1 
ATOM   7137 C  CG1 . ILE B 2 487 ? 153.848 169.900 140.687 1.00 71.50  ? 478 ILE A CG1 1 
ATOM   7138 C  CG2 . ILE B 2 487 ? 154.192 167.544 141.446 1.00 72.83  ? 478 ILE A CG2 1 
ATOM   7139 C  CD1 . ILE B 2 487 ? 155.173 170.186 141.352 1.00 72.59  ? 478 ILE A CD1 1 
ATOM   7140 N  N   . GLN B 2 488 ? 151.706 165.760 140.036 1.00 79.77  ? 479 GLN A N   1 
ATOM   7141 C  CA  . GLN B 2 488 ? 151.044 164.498 140.313 1.00 79.48  ? 479 GLN A CA  1 
ATOM   7142 C  C   . GLN B 2 488 ? 151.985 163.557 141.058 1.00 78.93  ? 479 GLN A C   1 
ATOM   7143 O  O   . GLN B 2 488 ? 153.077 163.942 141.489 1.00 77.66  ? 479 GLN A O   1 
ATOM   7144 C  CB  . GLN B 2 488 ? 150.542 163.874 139.012 1.00 73.99  ? 479 GLN A CB  1 
ATOM   7145 C  CG  . GLN B 2 488 ? 149.607 164.765 138.225 1.00 77.38  ? 479 GLN A CG  1 
ATOM   7146 C  CD  . GLN B 2 488 ? 149.625 164.453 136.747 1.00 88.14  ? 479 GLN A CD  1 
ATOM   7147 O  OE1 . GLN B 2 488 ? 149.738 163.294 136.349 1.00 87.54  ? 479 GLN A OE1 1 
ATOM   7148 N  NE2 . GLN B 2 488 ? 149.515 165.487 135.921 1.00 91.26  ? 479 GLN A NE2 1 
ATOM   7149 N  N   . ASP B 2 489 ? 151.540 162.314 141.221 1.00 78.00  ? 480 ASP A N   1 
ATOM   7150 C  CA  . ASP B 2 489 ? 152.331 161.311 141.918 1.00 77.02  ? 480 ASP A CA  1 
ATOM   7151 C  C   . ASP B 2 489 ? 153.631 161.039 141.173 1.00 74.47  ? 480 ASP A C   1 
ATOM   7152 O  O   . ASP B 2 489 ? 153.653 160.939 139.944 1.00 74.90  ? 480 ASP A O   1 
ATOM   7153 C  CB  . ASP B 2 489 ? 151.524 160.021 142.061 1.00 77.64  ? 480 ASP A CB  1 
ATOM   7154 C  CG  . ASP B 2 489 ? 151.950 159.197 143.254 1.00 82.12  ? 480 ASP A CG  1 
ATOM   7155 O  OD1 . ASP B 2 489 ? 152.987 159.524 143.865 1.00 87.53  ? 480 ASP A OD1 1 
ATOM   7156 O  OD2 . ASP B 2 489 ? 151.246 158.220 143.581 1.00 82.37  ? 480 ASP A OD2 1 
ATOM   7157 N  N   . ILE B 2 490 ? 154.720 160.925 141.926 1.00 70.38  ? 481 ILE A N   1 
ATOM   7158 C  CA  . ILE B 2 490 ? 156.037 160.618 141.383 1.00 67.96  ? 481 ILE A CA  1 
ATOM   7159 C  C   . ILE B 2 490 ? 156.560 159.371 142.080 1.00 73.18  ? 481 ILE A C   1 
ATOM   7160 O  O   . ILE B 2 490 ? 156.537 159.289 143.312 1.00 76.28  ? 481 ILE A O   1 
ATOM   7161 C  CB  . ILE B 2 490 ? 157.013 161.793 141.560 1.00 65.93  ? 481 ILE A CB  1 
ATOM   7162 C  CG1 . ILE B 2 490 ? 156.574 162.981 140.710 1.00 66.42  ? 481 ILE A CG1 1 
ATOM   7163 C  CG2 . ILE B 2 490 ? 158.415 161.375 141.190 1.00 67.08  ? 481 ILE A CG2 1 
ATOM   7164 C  CD1 . ILE B 2 490 ? 157.666 163.994 140.471 1.00 62.32  ? 481 ILE A CD1 1 
ATOM   7165 N  N   . SER B 2 491 ? 157.023 158.402 141.294 1.00 73.82  ? 482 SER A N   1 
ATOM   7166 C  CA  . SER B 2 491 ? 157.556 157.153 141.832 1.00 75.92  ? 482 SER A CA  1 
ATOM   7167 C  C   . SER B 2 491 ? 159.016 157.366 142.207 1.00 78.31  ? 482 SER A C   1 
ATOM   7168 O  O   . SER B 2 491 ? 159.911 157.247 141.369 1.00 76.91  ? 482 SER A O   1 
ATOM   7169 C  CB  . SER B 2 491 ? 157.406 156.025 140.820 1.00 73.20  ? 482 SER A CB  1 
ATOM   7170 O  OG  . SER B 2 491 ? 156.076 155.540 140.798 1.00 76.53  ? 482 SER A OG  1 
ATOM   7171 N  N   . TRP B 2 492 ? 159.260 157.671 143.477 1.00 76.58  ? 483 TRP A N   1 
ATOM   7172 C  CA  . TRP B 2 492 ? 160.600 157.971 143.948 1.00 73.40  ? 483 TRP A CA  1 
ATOM   7173 C  C   . TRP B 2 492 ? 161.420 156.695 144.108 1.00 78.02  ? 483 TRP A C   1 
ATOM   7174 O  O   . TRP B 2 492 ? 160.912 155.577 144.012 1.00 80.05  ? 483 TRP A O   1 
ATOM   7175 C  CB  . TRP B 2 492 ? 160.537 158.730 145.267 1.00 70.18  ? 483 TRP A CB  1 
ATOM   7176 C  CG  . TRP B 2 492 ? 159.914 160.073 145.148 1.00 69.90  ? 483 TRP A CG  1 
ATOM   7177 C  CD1 . TRP B 2 492 ? 158.738 160.475 145.691 1.00 73.01  ? 483 TRP A CD1 1 
ATOM   7178 C  CD2 . TRP B 2 492 ? 160.438 161.201 144.446 1.00 69.36  ? 483 TRP A CD2 1 
ATOM   7179 N  NE1 . TRP B 2 492 ? 158.492 161.784 145.372 1.00 70.64  ? 483 TRP A NE1 1 
ATOM   7180 C  CE2 . TRP B 2 492 ? 159.524 162.252 144.606 1.00 67.90  ? 483 TRP A CE2 1 
ATOM   7181 C  CE3 . TRP B 2 492 ? 161.592 161.423 143.695 1.00 68.74  ? 483 TRP A CE3 1 
ATOM   7182 C  CZ2 . TRP B 2 492 ? 159.726 163.504 144.046 1.00 64.68  ? 483 TRP A CZ2 1 
ATOM   7183 C  CZ3 . TRP B 2 492 ? 161.790 162.665 143.141 1.00 64.95  ? 483 TRP A CZ3 1 
ATOM   7184 C  CH2 . TRP B 2 492 ? 160.864 163.690 143.318 1.00 64.09  ? 483 TRP A CH2 1 
ATOM   7185 N  N   . HIS B 2 493 ? 162.714 156.877 144.355 1.00 78.29  ? 484 HIS A N   1 
ATOM   7186 C  CA  . HIS B 2 493 ? 163.639 155.774 144.565 1.00 76.43  ? 484 HIS A CA  1 
ATOM   7187 C  C   . HIS B 2 493 ? 163.860 155.452 146.035 1.00 77.40  ? 484 HIS A C   1 
ATOM   7188 O  O   . HIS B 2 493 ? 164.663 154.568 146.346 1.00 75.97  ? 484 HIS A O   1 
ATOM   7189 C  CB  . HIS B 2 493 ? 164.985 156.085 143.911 1.00 74.80  ? 484 HIS A CB  1 
ATOM   7190 C  CG  . HIS B 2 493 ? 165.735 157.196 144.575 1.00 75.47  ? 484 HIS A CG  1 
ATOM   7191 N  ND1 . HIS B 2 493 ? 165.295 158.501 144.566 1.00 73.51  ? 484 HIS A ND1 1 
ATOM   7192 C  CD2 . HIS B 2 493 ? 166.898 157.198 145.266 1.00 76.76  ? 484 HIS A CD2 1 
ATOM   7193 C  CE1 . HIS B 2 493 ? 166.154 159.258 145.223 1.00 72.01  ? 484 HIS A CE1 1 
ATOM   7194 N  NE2 . HIS B 2 493 ? 167.136 158.492 145.659 1.00 74.62  ? 484 HIS A NE2 1 
ATOM   7195 N  N   . THR B 2 494 ? 163.176 156.142 146.941 1.00 80.24  ? 485 THR A N   1 
ATOM   7196 C  CA  . THR B 2 494 ? 163.389 155.949 148.365 1.00 83.79  ? 485 THR A CA  1 
ATOM   7197 C  C   . THR B 2 494 ? 162.690 154.679 148.844 1.00 90.16  ? 485 THR A C   1 
ATOM   7198 O  O   . THR B 2 494 ? 161.976 154.006 148.097 1.00 88.99  ? 485 THR A O   1 
ATOM   7199 C  CB  . THR B 2 494 ? 162.896 157.161 149.142 1.00 81.77  ? 485 THR A CB  1 
ATOM   7200 O  OG1 . THR B 2 494 ? 161.527 157.403 148.808 1.00 87.27  ? 485 THR A OG1 1 
ATOM   7201 C  CG2 . THR B 2 494 ? 163.721 158.379 148.788 1.00 74.32  ? 485 THR A CG2 1 
ATOM   7202 N  N   . ILE B 2 495 ? 162.893 154.359 150.122 1.00 93.05  ? 486 ILE A N   1 
ATOM   7203 C  CA  . ILE B 2 495 ? 162.447 153.073 150.647 1.00 100.25 ? 486 ILE A CA  1 
ATOM   7204 C  C   . ILE B 2 495 ? 160.928 153.018 150.742 1.00 100.92 ? 486 ILE A C   1 
ATOM   7205 O  O   . ILE B 2 495 ? 160.307 152.015 150.373 1.00 107.82 ? 486 ILE A O   1 
ATOM   7206 C  CB  . ILE B 2 495 ? 163.109 152.799 152.008 1.00 104.37 ? 486 ILE A CB  1 
ATOM   7207 C  CG1 . ILE B 2 495 ? 164.604 153.117 151.945 1.00 102.23 ? 486 ILE A CG1 1 
ATOM   7208 C  CG2 . ILE B 2 495 ? 162.887 151.352 152.424 1.00 107.37 ? 486 ILE A CG2 1 
ATOM   7209 C  CD1 . ILE B 2 495 ? 165.365 152.293 150.928 1.00 99.38  ? 486 ILE A CD1 1 
ATOM   7210 N  N   . ASN B 2 496 ? 160.305 154.080 151.240 1.00 97.06  ? 487 ASN A N   1 
ATOM   7211 C  CA  . ASN B 2 496 ? 158.867 154.095 151.472 1.00 103.24 ? 487 ASN A CA  1 
ATOM   7212 C  C   . ASN B 2 496 ? 158.170 155.139 150.607 1.00 98.51  ? 487 ASN A C   1 
ATOM   7213 O  O   . ASN B 2 496 ? 157.128 155.673 150.989 1.00 101.00 ? 487 ASN A O   1 
ATOM   7214 C  CB  . ASN B 2 496 ? 158.563 154.340 152.948 1.00 115.69 ? 487 ASN A CB  1 
ATOM   7215 C  CG  . ASN B 2 496 ? 158.030 153.107 153.645 1.00 123.03 ? 487 ASN A CG  1 
ATOM   7216 O  OD1 . ASN B 2 496 ? 158.126 151.995 153.128 1.00 119.60 ? 487 ASN A OD1 1 
ATOM   7217 N  ND2 . ASN B 2 496 ? 157.462 153.299 154.828 1.00 130.29 ? 487 ASN A ND2 1 
ATOM   7218 N  N   . ASN B 2 497 ? 158.741 155.434 149.439 1.00 93.63  ? 488 ASN A N   1 
ATOM   7219 C  CA  . ASN B 2 497 ? 158.183 156.414 148.504 1.00 88.68  ? 488 ASN A CA  1 
ATOM   7220 C  C   . ASN B 2 497 ? 158.026 157.788 149.152 1.00 82.28  ? 488 ASN A C   1 
ATOM   7221 O  O   . ASN B 2 497 ? 157.044 158.495 148.923 1.00 78.46  ? 488 ASN A O   1 
ATOM   7222 C  CB  . ASN B 2 497 ? 156.850 155.932 147.929 1.00 87.97  ? 488 ASN A CB  1 
ATOM   7223 C  CG  . ASN B 2 497 ? 156.542 156.553 146.589 1.00 83.86  ? 488 ASN A CG  1 
ATOM   7224 O  OD1 . ASN B 2 497 ? 157.443 156.829 145.800 1.00 81.45  ? 488 ASN A OD1 1 
ATOM   7225 N  ND2 . ASN B 2 497 ? 155.264 156.781 146.324 1.00 86.20  ? 488 ASN A ND2 1 
ATOM   7226 N  N   . THR B 2 498 ? 158.999 158.167 149.970 1.00 80.55  ? 489 THR A N   1 
ATOM   7227 C  CA  . THR B 2 498 ? 159.041 159.500 150.548 1.00 77.64  ? 489 THR A CA  1 
ATOM   7228 C  C   . THR B 2 498 ? 159.907 160.414 149.691 1.00 78.89  ? 489 THR A C   1 
ATOM   7229 O  O   . THR B 2 498 ? 160.791 159.966 148.962 1.00 82.88  ? 489 THR A O   1 
ATOM   7230 C  CB  . THR B 2 498 ? 159.583 159.456 151.974 1.00 80.06  ? 489 THR A CB  1 
ATOM   7231 O  OG1 . THR B 2 498 ? 161.009 159.584 151.945 1.00 80.41  ? 489 THR A OG1 1 
ATOM   7232 C  CG2 . THR B 2 498 ? 159.212 158.142 152.639 1.00 83.51  ? 489 THR A CG2 1 
ATOM   7233 N  N   . ILE B 2 499 ? 159.645 161.709 149.789 1.00 74.72  ? 490 ILE A N   1 
ATOM   7234 C  CA  . ILE B 2 499 ? 160.371 162.676 148.959 1.00 70.92  ? 490 ILE A CA  1 
ATOM   7235 C  C   . ILE B 2 499 ? 161.844 162.664 149.346 1.00 71.86  ? 490 ILE A C   1 
ATOM   7236 O  O   . ILE B 2 499 ? 162.165 162.771 150.540 1.00 75.69  ? 490 ILE A O   1 
ATOM   7237 C  CB  . ILE B 2 499 ? 159.776 164.069 149.124 1.00 71.55  ? 490 ILE A CB  1 
ATOM   7238 C  CG1 . ILE B 2 499 ? 158.257 164.019 148.964 1.00 77.69  ? 490 ILE A CG1 1 
ATOM   7239 C  CG2 . ILE B 2 499 ? 160.396 165.026 148.133 1.00 74.04  ? 490 ILE A CG2 1 
ATOM   7240 C  CD1 . ILE B 2 499 ? 157.537 165.164 149.635 1.00 83.76  ? 490 ILE A CD1 1 
ATOM   7241 N  N   . PRO B 2 500 ? 162.764 162.513 148.396 1.00 69.72  ? 491 PRO A N   1 
ATOM   7242 C  CA  . PRO B 2 500 ? 164.188 162.584 148.737 1.00 70.60  ? 491 PRO A CA  1 
ATOM   7243 C  C   . PRO B 2 500 ? 164.531 163.936 149.336 1.00 71.90  ? 491 PRO A C   1 
ATOM   7244 O  O   . PRO B 2 500 ? 164.038 164.974 148.896 1.00 71.04  ? 491 PRO A O   1 
ATOM   7245 C  CB  . PRO B 2 500 ? 164.886 162.371 147.390 1.00 66.42  ? 491 PRO A CB  1 
ATOM   7246 C  CG  . PRO B 2 500 ? 163.889 161.659 146.559 1.00 67.66  ? 491 PRO A CG  1 
ATOM   7247 C  CD  . PRO B 2 500 ? 162.555 162.185 146.979 1.00 67.67  ? 491 PRO A CD  1 
ATOM   7248 N  N   . MET B 2 501 ? 165.385 163.915 150.351 1.00 72.83  ? 492 MET A N   1 
ATOM   7249 C  CA  . MET B 2 501 ? 165.772 165.120 151.067 1.00 71.87  ? 492 MET A CA  1 
ATOM   7250 C  C   . MET B 2 501 ? 167.143 165.563 150.583 1.00 71.88  ? 492 MET A C   1 
ATOM   7251 O  O   . MET B 2 501 ? 168.103 164.790 150.633 1.00 75.72  ? 492 MET A O   1 
ATOM   7252 C  CB  . MET B 2 501 ? 165.786 164.881 152.575 1.00 75.59  ? 492 MET A CB  1 
ATOM   7253 C  CG  . MET B 2 501 ? 164.424 164.986 153.230 1.00 83.09  ? 492 MET A CG  1 
ATOM   7254 S  SD  . MET B 2 501 ? 163.500 166.420 152.649 1.00 98.45  ? 492 MET A SD  1 
ATOM   7255 C  CE  . MET B 2 501 ? 161.823 165.931 153.043 1.00 84.46  ? 492 MET A CE  1 
ATOM   7256 N  N   . SER B 2 502 ? 167.228 166.802 150.109 1.00 68.75  ? 493 SER A N   1 
ATOM   7257 C  CA  . SER B 2 502 ? 168.493 167.408 149.701 1.00 68.19  ? 493 SER A CA  1 
ATOM   7258 C  C   . SER B 2 502 ? 168.584 168.770 150.376 1.00 74.04  ? 493 SER A C   1 
ATOM   7259 O  O   . SER B 2 502 ? 168.228 169.793 149.791 1.00 77.54  ? 493 SER A O   1 
ATOM   7260 C  CB  . SER B 2 502 ? 168.583 167.516 148.197 1.00 66.00  ? 493 SER A CB  1 
ATOM   7261 O  OG  . SER B 2 502 ? 169.928 167.448 147.770 1.00 70.82  ? 493 SER A OG  1 
ATOM   7262 N  N   . MET B 2 503 ? 169.067 168.779 151.613 1.00 73.45  ? 494 MET A N   1 
ATOM   7263 C  CA  . MET B 2 503 ? 169.293 170.008 152.353 1.00 72.02  ? 494 MET A CA  1 
ATOM   7264 C  C   . MET B 2 503 ? 170.641 169.910 153.041 1.00 77.78  ? 494 MET A C   1 
ATOM   7265 O  O   . MET B 2 503 ? 170.978 168.868 153.607 1.00 79.93  ? 494 MET A O   1 
ATOM   7266 C  CB  . MET B 2 503 ? 168.196 170.260 153.390 1.00 74.76  ? 494 MET A CB  1 
ATOM   7267 C  CG  . MET B 2 503 ? 166.804 170.393 152.814 1.00 76.86  ? 494 MET A CG  1 
ATOM   7268 S  SD  . MET B 2 503 ? 165.544 170.449 154.098 1.00 104.75 ? 494 MET A SD  1 
ATOM   7269 C  CE  . MET B 2 503 ? 164.566 171.844 153.548 1.00 80.56  ? 494 MET A CE  1 
ATOM   7270 N  N   . CYS B 2 504 ? 171.411 170.993 152.991 1.00 82.13  ? 495 CYS A N   1 
ATOM   7271 C  CA  . CYS B 2 504 ? 172.731 170.982 153.601 1.00 90.43  ? 495 CYS A CA  1 
ATOM   7272 C  C   . CYS B 2 504 ? 172.691 171.254 155.095 1.00 97.01  ? 495 CYS A C   1 
ATOM   7273 O  O   . CYS B 2 504 ? 173.733 171.163 155.750 1.00 99.00  ? 495 CYS A O   1 
ATOM   7274 C  CB  . CYS B 2 504 ? 173.640 172.004 152.920 1.00 90.94  ? 495 CYS A CB  1 
ATOM   7275 S  SG  . CYS B 2 504 ? 173.716 173.613 153.726 1.00 105.60 ? 495 CYS A SG  1 
ATOM   7276 N  N   . SER B 2 505 ? 171.525 171.576 155.647 1.00 96.01  ? 496 SER A N   1 
ATOM   7277 C  CA  . SER B 2 505 ? 171.427 171.888 157.069 1.00 99.44  ? 496 SER A CA  1 
ATOM   7278 C  C   . SER B 2 505 ? 170.017 171.589 157.543 1.00 98.58  ? 496 SER A C   1 
ATOM   7279 O  O   . SER B 2 505 ? 169.051 172.096 156.967 1.00 100.14 ? 496 SER A O   1 
ATOM   7280 C  CB  . SER B 2 505 ? 171.782 173.348 157.328 1.00 104.05 ? 496 SER A CB  1 
ATOM   7281 O  OG  . SER B 2 505 ? 173.179 173.510 157.474 1.00 108.19 ? 496 SER A OG  1 
ATOM   7282 N  N   . LYS B 2 506 ? 169.900 170.772 158.584 1.00 99.66  ? 497 LYS A N   1 
ATOM   7283 C  CA  . LYS B 2 506 ? 168.610 170.553 159.217 1.00 103.51 ? 497 LYS A CA  1 
ATOM   7284 C  C   . LYS B 2 506 ? 168.128 171.843 159.867 1.00 106.09 ? 497 LYS A C   1 
ATOM   7285 O  O   . LYS B 2 506 ? 168.921 172.615 160.410 1.00 107.97 ? 497 LYS A O   1 
ATOM   7286 C  CB  . LYS B 2 506 ? 168.715 169.441 160.258 1.00 105.55 ? 497 LYS A CB  1 
ATOM   7287 C  CG  . LYS B 2 506 ? 167.424 169.140 160.999 1.00 108.81 ? 497 LYS A CG  1 
ATOM   7288 C  CD  . LYS B 2 506 ? 166.586 168.109 160.265 1.00 107.96 ? 497 LYS A CD  1 
ATOM   7289 C  CE  . LYS B 2 506 ? 166.047 167.056 161.223 1.00 107.75 ? 497 LYS A CE  1 
ATOM   7290 N  NZ  . LYS B 2 506 ? 165.363 167.663 162.399 1.00 101.77 ? 497 LYS A NZ  1 
ATOM   7291 N  N   . ARG B 2 507 ? 166.821 172.078 159.799 1.00 108.45 ? 498 ARG A N   1 
ATOM   7292 C  CA  . ARG B 2 507 ? 166.249 173.290 160.366 1.00 113.04 ? 498 ARG A CA  1 
ATOM   7293 C  C   . ARG B 2 507 ? 166.509 173.355 161.865 1.00 115.82 ? 498 ARG A C   1 
ATOM   7294 O  O   . ARG B 2 507 ? 166.457 172.342 162.568 1.00 114.14 ? 498 ARG A O   1 
ATOM   7295 C  CB  . ARG B 2 507 ? 164.748 173.340 160.091 1.00 118.26 ? 498 ARG A CB  1 
ATOM   7296 C  CG  . ARG B 2 507 ? 164.393 173.614 158.642 1.00 117.11 ? 498 ARG A CG  1 
ATOM   7297 C  CD  . ARG B 2 507 ? 163.048 174.304 158.528 1.00 117.18 ? 498 ARG A CD  1 
ATOM   7298 N  NE  . ARG B 2 507 ? 162.208 173.678 157.514 1.00 123.57 ? 498 ARG A NE  1 
ATOM   7299 C  CZ  . ARG B 2 507 ? 161.396 172.656 157.744 1.00 132.02 ? 498 ARG A CZ  1 
ATOM   7300 N  NH1 . ARG B 2 507 ? 161.291 172.114 158.946 1.00 129.33 ? 498 ARG A NH1 1 
ATOM   7301 N  NH2 . ARG B 2 507 ? 160.673 172.164 156.743 1.00 138.74 ? 498 ARG A NH2 1 
ATOM   7302 N  N   . CYS B 2 508 ? 166.798 174.556 162.354 1.00 117.32 ? 499 CYS A N   1 
ATOM   7303 C  CA  . CYS B 2 508 ? 167.092 174.753 163.767 1.00 115.17 ? 499 CYS A CA  1 
ATOM   7304 C  C   . CYS B 2 508 ? 165.814 174.860 164.587 1.00 109.80 ? 499 CYS A C   1 
ATOM   7305 O  O   . CYS B 2 508 ? 165.136 175.885 164.561 1.00 107.70 ? 499 CYS A O   1 
ATOM   7306 C  CB  . CYS B 2 508 ? 167.947 176.003 163.963 1.00 118.65 ? 499 CYS A CB  1 
ATOM   7307 S  SG  . CYS B 2 508 ? 169.692 175.764 163.578 1.00 134.72 ? 499 CYS A SG  1 
ATOM   7308 N  N   . LYS B 2 514 ? 172.148 179.385 165.087 1.00 116.70 ? 505 LYS A N   1 
ATOM   7309 C  CA  . LYS B 2 514 ? 171.886 179.534 163.663 1.00 112.22 ? 505 LYS A CA  1 
ATOM   7310 C  C   . LYS B 2 514 ? 173.063 180.190 162.958 1.00 112.01 ? 505 LYS A C   1 
ATOM   7311 O  O   . LYS B 2 514 ? 172.899 180.798 161.903 1.00 111.19 ? 505 LYS A O   1 
ATOM   7312 C  CB  . LYS B 2 514 ? 170.617 180.359 163.438 1.00 110.56 ? 505 LYS A CB  1 
ATOM   7313 C  CG  . LYS B 2 514 ? 170.532 181.610 164.306 1.00 111.88 ? 505 LYS A CG  1 
ATOM   7314 C  CD  . LYS B 2 514 ? 169.320 182.466 163.956 1.00 106.10 ? 505 LYS A CD  1 
ATOM   7315 C  CE  . LYS B 2 514 ? 169.673 183.557 162.956 1.00 95.48  ? 505 LYS A CE  1 
ATOM   7316 N  NZ  . LYS B 2 514 ? 170.425 184.672 163.589 1.00 85.36  ? 505 LYS A NZ  1 
ATOM   7317 N  N   . LYS B 2 515 ? 174.249 180.072 163.545 1.00 112.61 ? 506 LYS A N   1 
ATOM   7318 C  CA  . LYS B 2 515 ? 175.409 180.741 162.980 1.00 113.61 ? 506 LYS A CA  1 
ATOM   7319 C  C   . LYS B 2 515 ? 175.785 180.108 161.642 1.00 115.64 ? 506 LYS A C   1 
ATOM   7320 O  O   . LYS B 2 515 ? 175.792 178.880 161.512 1.00 114.05 ? 506 LYS A O   1 
ATOM   7321 C  CB  . LYS B 2 515 ? 176.593 180.690 163.947 1.00 118.39 ? 506 LYS A CB  1 
ATOM   7322 C  CG  . LYS B 2 515 ? 177.180 179.313 164.193 1.00 119.96 ? 506 LYS A CG  1 
ATOM   7323 C  CD  . LYS B 2 515 ? 178.577 179.425 164.782 1.00 121.37 ? 506 LYS A CD  1 
ATOM   7324 C  CE  . LYS B 2 515 ? 179.605 179.749 163.706 1.00 121.81 ? 506 LYS A CE  1 
ATOM   7325 N  NZ  . LYS B 2 515 ? 180.860 180.315 164.275 1.00 114.34 ? 506 LYS A NZ  1 
ATOM   7326 N  N   . PRO B 2 516 ? 176.081 180.914 160.628 1.00 115.84 ? 507 PRO A N   1 
ATOM   7327 C  CA  . PRO B 2 516 ? 176.388 180.362 159.308 1.00 116.29 ? 507 PRO A CA  1 
ATOM   7328 C  C   . PRO B 2 516 ? 177.824 179.881 159.199 1.00 117.42 ? 507 PRO A C   1 
ATOM   7329 O  O   . PRO B 2 516 ? 178.747 180.441 159.795 1.00 116.09 ? 507 PRO A O   1 
ATOM   7330 C  CB  . PRO B 2 516 ? 176.136 181.548 158.372 1.00 112.19 ? 507 PRO A CB  1 
ATOM   7331 C  CG  . PRO B 2 516 ? 176.454 182.735 159.206 1.00 109.95 ? 507 PRO A CG  1 
ATOM   7332 C  CD  . PRO B 2 516 ? 176.066 182.387 160.621 1.00 111.42 ? 507 PRO A CD  1 
ATOM   7333 N  N   . VAL B 2 517 ? 178.000 178.820 158.414 1.00 116.92 ? 508 VAL A N   1 
ATOM   7334 C  CA  . VAL B 2 517 ? 179.313 178.282 158.084 1.00 116.34 ? 508 VAL A CA  1 
ATOM   7335 C  C   . VAL B 2 517 ? 179.403 178.143 156.572 1.00 112.52 ? 508 VAL A C   1 
ATOM   7336 O  O   . VAL B 2 517 ? 178.513 177.562 155.943 1.00 114.78 ? 508 VAL A O   1 
ATOM   7337 C  CB  . VAL B 2 517 ? 179.574 176.929 158.773 1.00 119.95 ? 508 VAL A CB  1 
ATOM   7338 C  CG1 . VAL B 2 517 ? 178.365 176.022 158.651 1.00 115.24 ? 508 VAL A CG1 1 
ATOM   7339 C  CG2 . VAL B 2 517 ? 180.800 176.260 158.175 1.00 119.05 ? 508 VAL A CG2 1 
ATOM   7340 N  N   . GLY B 2 518 ? 180.470 178.680 155.992 1.00 108.61 ? 509 GLY A N   1 
ATOM   7341 C  CA  . GLY B 2 518 ? 180.666 178.629 154.561 1.00 102.25 ? 509 GLY A CA  1 
ATOM   7342 C  C   . GLY B 2 518 ? 179.988 179.778 153.839 1.00 98.99  ? 509 GLY A C   1 
ATOM   7343 O  O   . GLY B 2 518 ? 179.240 180.574 154.412 1.00 99.39  ? 509 GLY A O   1 
ATOM   7344 N  N   . ILE B 2 519 ? 180.265 179.857 152.537 1.00 96.86  ? 510 ILE A N   1 
ATOM   7345 C  CA  . ILE B 2 519 ? 179.711 180.931 151.721 1.00 95.75  ? 510 ILE A CA  1 
ATOM   7346 C  C   . ILE B 2 519 ? 178.197 180.814 151.637 1.00 101.72 ? 510 ILE A C   1 
ATOM   7347 O  O   . ILE B 2 519 ? 177.476 181.809 151.773 1.00 104.54 ? 510 ILE A O   1 
ATOM   7348 C  CB  . ILE B 2 519 ? 180.351 180.920 150.322 1.00 94.20  ? 510 ILE A CB  1 
ATOM   7349 C  CG1 . ILE B 2 519 ? 181.846 180.611 150.413 1.00 96.82  ? 510 ILE A CG1 1 
ATOM   7350 C  CG2 . ILE B 2 519 ? 180.116 182.245 149.620 1.00 94.91  ? 510 ILE A CG2 1 
ATOM   7351 C  CD1 . ILE B 2 519 ? 182.220 179.226 149.925 1.00 93.84  ? 510 ILE A CD1 1 
ATOM   7352 N  N   . HIS B 2 520 ? 177.692 179.604 151.420 1.00 100.70 ? 511 HIS A N   1 
ATOM   7353 C  CA  . HIS B 2 520 ? 176.278 179.419 151.131 1.00 97.97  ? 511 HIS A CA  1 
ATOM   7354 C  C   . HIS B 2 520 ? 175.418 179.775 152.334 1.00 98.66  ? 511 HIS A C   1 
ATOM   7355 O  O   . HIS B 2 520 ? 175.708 179.382 153.467 1.00 99.89  ? 511 HIS A O   1 
ATOM   7356 C  CB  . HIS B 2 520 ? 176.018 177.979 150.701 1.00 94.76  ? 511 HIS A CB  1 
ATOM   7357 C  CG  . HIS B 2 520 ? 176.992 177.473 149.685 1.00 93.38  ? 511 HIS A CG  1 
ATOM   7358 N  ND1 . HIS B 2 520 ? 177.959 176.539 149.983 1.00 92.01  ? 511 HIS A ND1 1 
ATOM   7359 C  CD2 . HIS B 2 520 ? 177.154 177.779 148.377 1.00 90.66  ? 511 HIS A CD2 1 
ATOM   7360 C  CE1 . HIS B 2 520 ? 178.672 176.287 148.900 1.00 89.05  ? 511 HIS A CE1 1 
ATOM   7361 N  NE2 . HIS B 2 520 ? 178.205 177.027 147.912 1.00 88.99  ? 511 HIS A NE2 1 
ATOM   7362 N  N   . VAL B 2 521 ? 174.348 180.527 152.075 1.00 98.89  ? 512 VAL A N   1 
ATOM   7363 C  CA  . VAL B 2 521 ? 173.472 180.980 153.150 1.00 102.23 ? 512 VAL A CA  1 
ATOM   7364 C  C   . VAL B 2 521 ? 172.717 179.806 153.758 1.00 104.07 ? 512 VAL A C   1 
ATOM   7365 O  O   . VAL B 2 521 ? 172.504 179.751 154.975 1.00 104.40 ? 512 VAL A O   1 
ATOM   7366 C  CB  . VAL B 2 521 ? 172.517 182.068 152.626 1.00 98.28  ? 512 VAL A CB  1 
ATOM   7367 C  CG1 . VAL B 2 521 ? 171.915 181.651 151.296 1.00 97.97  ? 512 VAL A CG1 1 
ATOM   7368 C  CG2 . VAL B 2 521 ? 171.429 182.364 153.641 1.00 92.30  ? 512 VAL A CG2 1 
ATOM   7369 N  N   . CYS B 2 522 ? 172.316 178.842 152.931 1.00 102.83 ? 513 CYS A N   1 
ATOM   7370 C  CA  . CYS B 2 522 ? 171.532 177.713 153.413 1.00 103.32 ? 513 CYS A CA  1 
ATOM   7371 C  C   . CYS B 2 522 ? 172.328 176.766 154.302 1.00 106.69 ? 513 CYS A C   1 
ATOM   7372 O  O   . CYS B 2 522 ? 171.726 175.883 154.921 1.00 106.76 ? 513 CYS A O   1 
ATOM   7373 C  CB  . CYS B 2 522 ? 170.948 176.939 152.233 1.00 99.05  ? 513 CYS A CB  1 
ATOM   7374 S  SG  . CYS B 2 522 ? 172.177 176.342 151.062 1.00 105.83 ? 513 CYS A SG  1 
ATOM   7375 N  N   . CYS B 2 523 ? 173.647 176.914 154.379 1.00 106.51 ? 514 CYS A N   1 
ATOM   7376 C  CA  . CYS B 2 523 ? 174.479 176.066 155.222 1.00 108.31 ? 514 CYS A CA  1 
ATOM   7377 C  C   . CYS B 2 523 ? 174.788 176.779 156.530 1.00 108.75 ? 514 CYS A C   1 
ATOM   7378 O  O   . CYS B 2 523 ? 175.177 177.951 156.528 1.00 110.59 ? 514 CYS A O   1 
ATOM   7379 C  CB  . CYS B 2 523 ? 175.776 175.685 154.510 1.00 107.83 ? 514 CYS A CB  1 
ATOM   7380 S  SG  . CYS B 2 523 ? 175.662 174.166 153.546 1.00 108.90 ? 514 CYS A SG  1 
ATOM   7381 N  N   . PHE B 2 524 ? 174.612 176.070 157.641 1.00 111.15 ? 515 PHE A N   1 
ATOM   7382 C  CA  . PHE B 2 524 ? 174.881 176.612 158.966 1.00 114.15 ? 515 PHE A CA  1 
ATOM   7383 C  C   . PHE B 2 524 ? 174.977 175.449 159.945 1.00 119.35 ? 515 PHE A C   1 
ATOM   7384 O  O   . PHE B 2 524 ? 174.800 174.286 159.575 1.00 119.96 ? 515 PHE A O   1 
ATOM   7385 C  CB  . PHE B 2 524 ? 173.799 177.608 159.383 1.00 114.42 ? 515 PHE A CB  1 
ATOM   7386 C  CG  . PHE B 2 524 ? 172.404 177.133 159.112 1.00 111.62 ? 515 PHE A CG  1 
ATOM   7387 C  CD1 . PHE B 2 524 ? 171.830 176.147 159.890 1.00 111.64 ? 515 PHE A CD1 1 
ATOM   7388 C  CD2 . PHE B 2 524 ? 171.665 177.679 158.083 1.00 111.21 ? 515 PHE A CD2 1 
ATOM   7389 C  CE1 . PHE B 2 524 ? 170.550 175.714 159.645 1.00 109.38 ? 515 PHE A CE1 1 
ATOM   7390 C  CE2 . PHE B 2 524 ? 170.382 177.248 157.834 1.00 114.68 ? 515 PHE A CE2 1 
ATOM   7391 C  CZ  . PHE B 2 524 ? 169.825 176.265 158.616 1.00 111.46 ? 515 PHE A CZ  1 
ATOM   7392 N  N   . GLU B 2 525 ? 175.257 175.771 161.206 1.00 119.26 ? 516 GLU A N   1 
ATOM   7393 C  CA  . GLU B 2 525 ? 175.220 174.791 162.282 1.00 116.47 ? 516 GLU A CA  1 
ATOM   7394 C  C   . GLU B 2 525 ? 174.270 175.291 163.356 1.00 115.96 ? 516 GLU A C   1 
ATOM   7395 O  O   . GLU B 2 525 ? 174.330 176.460 163.749 1.00 115.36 ? 516 GLU A O   1 
ATOM   7396 C  CB  . GLU B 2 525 ? 176.609 174.532 162.872 1.00 116.41 ? 516 GLU A CB  1 
ATOM   7397 C  CG  . GLU B 2 525 ? 177.410 175.779 163.186 1.00 121.43 ? 516 GLU A CG  1 
ATOM   7398 C  CD  . GLU B 2 525 ? 178.683 175.467 163.949 1.00 124.16 ? 516 GLU A CD  1 
ATOM   7399 O  OE1 . GLU B 2 525 ? 178.973 174.271 164.157 1.00 125.19 ? 516 GLU A OE1 1 
ATOM   7400 O  OE2 . GLU B 2 525 ? 179.393 176.415 164.344 1.00 120.62 ? 516 GLU A OE2 1 
ATOM   7401 N  N   . CYS B 2 526 ? 173.389 174.410 163.817 1.00 112.64 ? 517 CYS A N   1 
ATOM   7402 C  CA  . CYS B 2 526 ? 172.392 174.798 164.802 1.00 117.14 ? 517 CYS A CA  1 
ATOM   7403 C  C   . CYS B 2 526 ? 173.052 175.134 166.132 1.00 114.58 ? 517 CYS A C   1 
ATOM   7404 O  O   . CYS B 2 526 ? 174.041 174.513 166.532 1.00 109.27 ? 517 CYS A O   1 
ATOM   7405 C  CB  . CYS B 2 526 ? 171.369 173.680 164.984 1.00 119.74 ? 517 CYS A CB  1 
ATOM   7406 S  SG  . CYS B 2 526 ? 169.987 173.772 163.829 1.00 134.65 ? 517 CYS A SG  1 
ATOM   7407 N  N   . ILE B 2 527 ? 172.501 176.129 166.816 1.00 117.79 ? 518 ILE A N   1 
ATOM   7408 C  CA  . ILE B 2 527 ? 173.038 176.571 168.093 1.00 111.83 ? 518 ILE A CA  1 
ATOM   7409 C  C   . ILE B 2 527 ? 171.936 176.571 169.144 1.00 110.56 ? 518 ILE A C   1 
ATOM   7410 O  O   . ILE B 2 527 ? 170.761 176.385 168.824 1.00 105.75 ? 518 ILE A O   1 
ATOM   7411 C  CB  . ILE B 2 527 ? 173.682 177.960 167.970 1.00 110.18 ? 518 ILE A CB  1 
ATOM   7412 C  CG1 . ILE B 2 527 ? 174.980 178.015 168.773 1.00 108.25 ? 518 ILE A CG1 1 
ATOM   7413 C  CG2 . ILE B 2 527 ? 172.715 179.042 168.430 1.00 101.43 ? 518 ILE A CG2 1 
ATOM   7414 C  CD1 . ILE B 2 527 ? 176.142 177.329 168.093 1.00 99.75  ? 518 ILE A CD1 1 
HETATM 7415 O  O3  . RRY C 3 .   ? 171.390 167.339 122.095 1.00 99.50  ? 1   RRY C O3  1 
HETATM 7416 C  C3  . RRY C 3 .   ? 171.843 168.335 121.167 1.00 107.31 ? 1   RRY C C3  1 
HETATM 7417 C  C4  . RRY C 3 .   ? 172.291 167.684 119.924 1.00 110.09 ? 1   RRY C C4  1 
HETATM 7418 O  O4  . RRY C 3 .   ? 173.724 167.641 119.883 1.00 110.51 ? 1   RRY C O4  1 
HETATM 7419 C  C5  . RRY C 3 .   ? 171.782 168.519 118.805 1.00 106.54 ? 1   RRY C C5  1 
HETATM 7420 C  C6  . RRY C 3 .   ? 171.265 167.637 117.715 1.00 106.24 ? 1   RRY C C6  1 
HETATM 7421 CL CL6 . RRY C 3 .   ? 172.529 166.482 117.217 1.00 117.55 ? 1   RRY C CL6 1 
HETATM 7422 O  O5  . RRY C 3 .   ? 170.677 169.322 119.341 1.00 103.22 ? 1   RRY C O5  1 
HETATM 7423 C  C2  . RRY C 3 .   ? 170.711 169.234 120.805 1.00 106.28 ? 1   RRY C C2  1 
HETATM 7424 C  C1  . RRY C 3 .   ? 170.943 170.584 121.402 1.00 105.13 ? 1   RRY C C1  1 
HETATM 7425 CL CL1 . RRY C 3 .   ? 172.667 171.031 121.251 1.00 109.41 ? 1   RRY C CL1 1 
HETATM 7426 O  O2  . RRY C 3 .   ? 169.511 168.706 121.309 1.00 103.48 ? 1   RRY C O2  1 
HETATM 7427 C  C1  . RRJ C 3 .   ? 168.537 168.592 120.327 1.00 102.08 ? 2   RRJ C C1  1 
HETATM 7428 O  O5  . RRJ C 3 .   ? 168.291 167.211 120.122 1.00 105.04 ? 2   RRJ C O5  1 
HETATM 7429 C  C5  . RRJ C 3 .   ? 167.079 166.789 119.535 1.00 103.26 ? 2   RRJ C C5  1 
HETATM 7430 C  C6  . RRJ C 3 .   ? 167.099 167.094 118.040 1.00 101.75 ? 2   RRJ C C6  1 
HETATM 7431 O  O6  . RRJ C 3 .   ? 168.144 166.386 117.437 1.00 101.05 ? 2   RRJ C O6  1 
HETATM 7432 C  C4  . RRJ C 3 .   ? 165.860 167.439 120.183 1.00 102.22 ? 2   RRJ C C4  1 
HETATM 7433 CL CL4 . RRJ C 3 .   ? 164.974 168.414 118.965 1.00 114.93 ? 2   RRJ C CL4 1 
HETATM 7434 C  C3  . RRJ C 3 .   ? 166.284 168.330 121.329 1.00 97.11  ? 2   RRJ C C3  1 
HETATM 7435 O  O3  . RRJ C 3 .   ? 165.158 169.007 121.824 1.00 91.74  ? 2   RRJ C O3  1 
HETATM 7436 C  C2  . RRJ C 3 .   ? 167.288 169.339 120.800 1.00 97.66  ? 2   RRJ C C2  1 
HETATM 7437 O  O2  . RRJ C 3 .   ? 167.652 170.220 121.818 1.00 94.10  ? 2   RRJ C O2  1 
HETATM 7438 C  C1  . NAG D 4 .   ? 211.723 180.620 127.689 1.00 105.00 ? 601 NAG B C1  1 
HETATM 7439 C  C2  . NAG D 4 .   ? 212.784 180.010 126.773 1.00 108.53 ? 601 NAG B C2  1 
HETATM 7440 C  C3  . NAG D 4 .   ? 213.816 179.238 127.591 1.00 111.38 ? 601 NAG B C3  1 
HETATM 7441 C  C4  . NAG D 4 .   ? 214.359 180.116 128.711 1.00 113.11 ? 601 NAG B C4  1 
HETATM 7442 C  C5  . NAG D 4 .   ? 213.175 180.623 129.536 1.00 109.56 ? 601 NAG B C5  1 
HETATM 7443 C  C6  . NAG D 4 .   ? 213.558 181.463 130.730 1.00 103.38 ? 601 NAG B C6  1 
HETATM 7444 C  C7  . NAG D 4 .   ? 211.946 179.508 124.524 1.00 112.34 ? 601 NAG B C7  1 
HETATM 7445 C  C8  . NAG D 4 .   ? 211.255 178.469 123.678 1.00 112.66 ? 601 NAG B C8  1 
HETATM 7446 N  N2  . NAG D 4 .   ? 212.147 179.161 125.806 1.00 109.40 ? 601 NAG B N2  1 
HETATM 7447 O  O3  . NAG D 4 .   ? 214.829 178.808 126.721 1.00 108.85 ? 601 NAG B O3  1 
HETATM 7448 O  O4  . NAG D 4 .   ? 215.243 179.335 129.482 1.00 110.60 ? 601 NAG B O4  1 
HETATM 7449 O  O5  . NAG D 4 .   ? 212.348 181.389 128.687 1.00 108.09 ? 601 NAG B O5  1 
HETATM 7450 O  O6  . NAG D 4 .   ? 212.392 181.966 131.336 1.00 98.38  ? 601 NAG B O6  1 
HETATM 7451 O  O7  . NAG D 4 .   ? 212.292 180.582 124.058 1.00 113.78 ? 601 NAG B O7  1 
HETATM 7452 C  C1  . NAG E 4 .   ? 180.221 205.070 140.626 1.00 110.96 ? 602 NAG B C1  1 
HETATM 7453 C  C2  . NAG E 4 .   ? 179.362 205.605 139.477 1.00 110.91 ? 602 NAG B C2  1 
HETATM 7454 C  C3  . NAG E 4 .   ? 178.381 206.643 140.009 1.00 115.45 ? 602 NAG B C3  1 
HETATM 7455 C  C4  . NAG E 4 .   ? 177.592 206.081 141.186 1.00 119.48 ? 602 NAG B C4  1 
HETATM 7456 C  C5  . NAG E 4 .   ? 178.576 205.554 142.234 1.00 117.20 ? 602 NAG B C5  1 
HETATM 7457 C  C6  . NAG E 4 .   ? 177.926 204.982 143.474 1.00 108.49 ? 602 NAG B C6  1 
HETATM 7458 C  C7  . NAG E 4 .   ? 180.284 205.719 137.206 1.00 109.63 ? 602 NAG B C7  1 
HETATM 7459 C  C8  . NAG E 4 .   ? 181.228 206.484 136.312 1.00 109.22 ? 602 NAG B C8  1 
HETATM 7460 N  N2  . NAG E 4 .   ? 180.196 206.182 138.463 1.00 109.02 ? 602 NAG B N2  1 
HETATM 7461 O  O3  . NAG E 4 .   ? 177.550 207.028 138.947 1.00 114.63 ? 602 NAG B O3  1 
HETATM 7462 O  O4  . NAG E 4 .   ? 176.795 207.126 141.694 1.00 113.21 ? 602 NAG B O4  1 
HETATM 7463 O  O5  . NAG E 4 .   ? 179.379 204.560 141.632 1.00 115.06 ? 602 NAG B O5  1 
HETATM 7464 O  O6  . NAG E 4 .   ? 176.989 203.998 143.111 1.00 111.38 ? 602 NAG B O6  1 
HETATM 7465 O  O7  . NAG E 4 .   ? 179.655 204.754 136.803 1.00 109.45 ? 602 NAG B O7  1 
HETATM 7466 C  C1  . NAG F 4 .   ? 183.669 192.338 153.652 1.00 125.33 ? 603 NAG B C1  1 
HETATM 7467 C  C2  . NAG F 4 .   ? 182.527 193.020 154.412 1.00 126.47 ? 603 NAG B C2  1 
HETATM 7468 C  C3  . NAG F 4 .   ? 183.126 193.744 155.611 1.00 124.52 ? 603 NAG B C3  1 
HETATM 7469 C  C4  . NAG F 4 .   ? 183.943 192.775 156.462 1.00 123.40 ? 603 NAG B C4  1 
HETATM 7470 C  C5  . NAG F 4 .   ? 184.916 191.960 155.599 1.00 122.89 ? 603 NAG B C5  1 
HETATM 7471 C  C6  . NAG F 4 .   ? 185.596 190.838 156.349 1.00 119.02 ? 603 NAG B C6  1 
HETATM 7472 C  C7  . NAG F 4 .   ? 182.189 194.938 152.829 1.00 122.34 ? 603 NAG B C7  1 
HETATM 7473 C  C8  . NAG F 4 .   ? 181.100 195.651 152.068 1.00 116.62 ? 603 NAG B C8  1 
HETATM 7474 N  N2  . NAG F 4 .   ? 181.751 193.903 153.575 1.00 127.72 ? 603 NAG B N2  1 
HETATM 7475 O  O3  . NAG F 4 .   ? 182.072 194.318 156.336 1.00 123.86 ? 603 NAG B O3  1 
HETATM 7476 O  O4  . NAG F 4 .   ? 184.636 193.553 157.411 1.00 122.66 ? 603 NAG B O4  1 
HETATM 7477 O  O5  . NAG F 4 .   ? 184.234 191.380 154.509 1.00 123.25 ? 603 NAG B O5  1 
HETATM 7478 O  O6  . NAG F 4 .   ? 184.655 189.827 156.619 1.00 116.32 ? 603 NAG B O6  1 
HETATM 7479 O  O7  . NAG F 4 .   ? 183.352 195.304 152.751 1.00 119.55 ? 603 NAG B O7  1 
HETATM 7480 C  C1  . NAG G 4 .   ? 213.606 180.391 89.307  1.00 125.51 ? 604 NAG B C1  1 
HETATM 7481 C  C2  . NAG G 4 .   ? 214.463 179.282 88.681  1.00 127.76 ? 604 NAG B C2  1 
HETATM 7482 C  C3  . NAG G 4 .   ? 214.714 179.585 87.207  1.00 126.94 ? 604 NAG B C3  1 
HETATM 7483 C  C4  . NAG G 4 .   ? 213.386 179.801 86.497  1.00 130.38 ? 604 NAG B C4  1 
HETATM 7484 C  C5  . NAG G 4 .   ? 212.590 180.882 87.236  1.00 130.66 ? 604 NAG B C5  1 
HETATM 7485 C  C6  . NAG G 4 .   ? 211.242 181.163 86.612  1.00 127.80 ? 604 NAG B C6  1 
HETATM 7486 C  C7  . NAG G 4 .   ? 216.688 179.964 89.586  1.00 127.90 ? 604 NAG B C7  1 
HETATM 7487 C  C8  . NAG G 4 .   ? 217.848 179.440 90.396  1.00 122.27 ? 604 NAG B C8  1 
HETATM 7488 N  N2  . NAG G 4 .   ? 215.693 179.074 89.404  1.00 127.35 ? 604 NAG B N2  1 
HETATM 7489 O  O3  . NAG G 4 .   ? 215.431 178.511 86.662  1.00 124.51 ? 604 NAG B O3  1 
HETATM 7490 O  O4  . NAG G 4 .   ? 213.672 180.176 85.170  1.00 128.12 ? 604 NAG B O4  1 
HETATM 7491 O  O5  . NAG G 4 .   ? 212.403 180.490 88.583  1.00 127.55 ? 604 NAG B O5  1 
HETATM 7492 O  O6  . NAG G 4 .   ? 210.581 179.950 86.344  1.00 125.53 ? 604 NAG B O6  1 
HETATM 7493 O  O7  . NAG G 4 .   ? 216.686 181.106 89.147  1.00 127.97 ? 604 NAG B O7  1 
HETATM 7494 C  C1  . NAG H 4 .   ? 208.561 201.795 96.728  1.00 118.89 ? 605 NAG B C1  1 
HETATM 7495 C  C2  . NAG H 4 .   ? 208.275 202.787 97.861  1.00 119.91 ? 605 NAG B C2  1 
HETATM 7496 C  C3  . NAG H 4 .   ? 208.112 204.189 97.276  1.00 124.43 ? 605 NAG B C3  1 
HETATM 7497 C  C4  . NAG H 4 .   ? 209.293 204.553 96.381  1.00 127.71 ? 605 NAG B C4  1 
HETATM 7498 C  C5  . NAG H 4 .   ? 209.521 203.438 95.356  1.00 127.99 ? 605 NAG B C5  1 
HETATM 7499 C  C6  . NAG H 4 .   ? 210.701 203.674 94.440  1.00 126.20 ? 605 NAG B C6  1 
HETATM 7500 C  C7  . NAG H 4 .   ? 207.075 201.950 99.857  1.00 115.98 ? 605 NAG B C7  1 
HETATM 7501 C  C8  . NAG H 4 .   ? 208.417 201.852 100.540 1.00 112.49 ? 605 NAG B C8  1 
HETATM 7502 N  N2  . NAG H 4 .   ? 207.096 202.401 98.589  1.00 116.61 ? 605 NAG B N2  1 
HETATM 7503 O  O3  . NAG H 4 .   ? 207.965 205.092 98.339  1.00 119.18 ? 605 NAG B O3  1 
HETATM 7504 O  O4  . NAG H 4 .   ? 208.978 205.775 95.754  1.00 121.92 ? 605 NAG B O4  1 
HETATM 7505 O  O5  . NAG H 4 .   ? 209.712 202.217 96.039  1.00 123.95 ? 605 NAG B O5  1 
HETATM 7506 O  O6  . NAG H 4 .   ? 210.812 202.604 93.533  1.00 123.95 ? 605 NAG B O6  1 
HETATM 7507 O  O7  . NAG H 4 .   ? 206.047 201.634 100.435 1.00 112.73 ? 605 NAG B O7  1 
HETATM 7508 C  C1  . NAG I 4 .   ? 182.697 167.370 95.821  1.00 124.29 ? 606 NAG B C1  1 
HETATM 7509 C  C2  . NAG I 4 .   ? 183.316 166.018 96.190  1.00 126.60 ? 606 NAG B C2  1 
HETATM 7510 C  C3  . NAG I 4 .   ? 183.504 165.182 94.931  1.00 123.84 ? 606 NAG B C3  1 
HETATM 7511 C  C4  . NAG I 4 .   ? 182.190 165.090 94.166  1.00 126.39 ? 606 NAG B C4  1 
HETATM 7512 C  C5  . NAG I 4 .   ? 181.653 166.501 93.907  1.00 123.05 ? 606 NAG B C5  1 
HETATM 7513 C  C6  . NAG I 4 .   ? 180.344 166.533 93.151  1.00 119.32 ? 606 NAG B C6  1 
HETATM 7514 C  C7  . NAG I 4 .   ? 184.761 166.103 98.204  1.00 129.33 ? 606 NAG B C7  1 
HETATM 7515 C  C8  . NAG I 4 .   ? 183.548 165.725 99.020  1.00 124.27 ? 606 NAG B C8  1 
HETATM 7516 N  N2  . NAG I 4 .   ? 184.565 166.218 96.875  1.00 129.96 ? 606 NAG B N2  1 
HETATM 7517 O  O3  . NAG I 4 .   ? 183.978 163.923 95.324  1.00 116.90 ? 606 NAG B O3  1 
HETATM 7518 O  O4  . NAG I 4 .   ? 182.456 164.405 92.965  1.00 127.18 ? 606 NAG B O4  1 
HETATM 7519 O  O5  . NAG I 4 .   ? 181.482 167.160 95.145  1.00 122.88 ? 606 NAG B O5  1 
HETATM 7520 O  O6  . NAG I 4 .   ? 180.548 166.110 91.824  1.00 116.33 ? 606 NAG B O6  1 
HETATM 7521 O  O7  . NAG I 4 .   ? 185.845 166.287 98.737  1.00 127.57 ? 606 NAG B O7  1 
HETATM 7522 C  C1  . NAG J 4 .   ? 187.654 215.638 111.456 1.00 124.55 ? 607 NAG B C1  1 
HETATM 7523 C  C2  . NAG J 4 .   ? 186.301 214.917 111.512 1.00 124.50 ? 607 NAG B C2  1 
HETATM 7524 C  C3  . NAG J 4 .   ? 185.204 215.933 111.816 1.00 126.72 ? 607 NAG B C3  1 
HETATM 7525 C  C4  . NAG J 4 .   ? 185.533 216.691 113.093 1.00 128.09 ? 607 NAG B C4  1 
HETATM 7526 C  C5  . NAG J 4 .   ? 186.918 217.326 112.956 1.00 130.93 ? 607 NAG B C5  1 
HETATM 7527 C  C6  . NAG J 4 .   ? 187.364 218.035 114.211 1.00 133.34 ? 607 NAG B C6  1 
HETATM 7528 C  C7  . NAG J 4 .   ? 185.502 212.993 110.172 1.00 124.13 ? 607 NAG B C7  1 
HETATM 7529 C  C8  . NAG J 4 .   ? 185.174 212.297 111.471 1.00 118.62 ? 607 NAG B C8  1 
HETATM 7530 N  N2  . NAG J 4 .   ? 186.029 214.228 110.280 1.00 124.31 ? 607 NAG B N2  1 
HETATM 7531 O  O3  . NAG J 4 .   ? 183.986 215.246 111.923 1.00 126.88 ? 607 NAG B O3  1 
HETATM 7532 O  O4  . NAG J 4 .   ? 184.531 217.664 113.278 1.00 121.72 ? 607 NAG B O4  1 
HETATM 7533 O  O5  . NAG J 4 .   ? 187.866 216.322 112.668 1.00 129.18 ? 607 NAG B O5  1 
HETATM 7534 O  O6  . NAG J 4 .   ? 187.227 217.160 115.305 1.00 135.64 ? 607 NAG B O6  1 
HETATM 7535 O  O7  . NAG J 4 .   ? 185.290 212.450 109.099 1.00 125.03 ? 607 NAG B O7  1 
HETATM 7536 C  C1  . NAG K 4 .   ? 206.588 171.429 110.507 1.00 127.12 ? 608 NAG B C1  1 
HETATM 7537 C  C2  . NAG K 4 .   ? 207.912 172.200 110.437 1.00 128.85 ? 608 NAG B C2  1 
HETATM 7538 C  C3  . NAG K 4 .   ? 209.019 171.347 111.049 1.00 129.75 ? 608 NAG B C3  1 
HETATM 7539 C  C4  . NAG K 4 .   ? 208.624 170.887 112.449 1.00 131.02 ? 608 NAG B C4  1 
HETATM 7540 C  C5  . NAG K 4 .   ? 207.246 170.211 112.411 1.00 130.40 ? 608 NAG B C5  1 
HETATM 7541 C  C6  . NAG K 4 .   ? 206.730 169.772 113.764 1.00 121.76 ? 608 NAG B C6  1 
HETATM 7542 C  C7  . NAG K 4 .   ? 208.619 173.771 108.662 1.00 124.73 ? 608 NAG B C7  1 
HETATM 7543 C  C8  . NAG K 4 .   ? 208.747 174.819 109.741 1.00 116.56 ? 608 NAG B C8  1 
HETATM 7544 N  N2  . NAG K 4 .   ? 208.221 172.552 109.076 1.00 126.65 ? 608 NAG B N2  1 
HETATM 7545 O  O3  . NAG K 4 .   ? 210.198 172.107 111.063 1.00 125.44 ? 608 NAG B O3  1 
HETATM 7546 O  O4  . NAG K 4 .   ? 209.629 170.003 112.888 1.00 129.38 ? 608 NAG B O4  1 
HETATM 7547 O  O5  . NAG K 4 .   ? 206.305 171.102 111.847 1.00 131.43 ? 608 NAG B O5  1 
HETATM 7548 O  O6  . NAG K 4 .   ? 206.501 170.898 114.578 1.00 114.83 ? 608 NAG B O6  1 
HETATM 7549 O  O7  . NAG K 4 .   ? 208.870 174.030 107.495 1.00 126.46 ? 608 NAG B O7  1 
HETATM 7550 C  C1  . NAG L 4 .   ? 156.923 152.194 155.574 1.00 140.73 ? 601 NAG A C1  1 
HETATM 7551 C  C2  . NAG L 4 .   ? 157.611 152.053 156.935 1.00 146.11 ? 601 NAG A C2  1 
HETATM 7552 C  C3  . NAG L 4 .   ? 157.002 150.881 157.699 1.00 151.65 ? 601 NAG A C3  1 
HETATM 7553 C  C4  . NAG L 4 .   ? 155.486 151.023 157.778 1.00 154.51 ? 601 NAG A C4  1 
HETATM 7554 C  C5  . NAG L 4 .   ? 154.916 151.230 156.370 1.00 149.56 ? 601 NAG A C5  1 
HETATM 7555 C  C6  . NAG L 4 .   ? 153.420 151.454 156.342 1.00 146.70 ? 601 NAG A C6  1 
HETATM 7556 C  C7  . NAG L 4 .   ? 159.952 152.800 157.096 1.00 138.95 ? 601 NAG A C7  1 
HETATM 7557 C  C8  . NAG L 4 .   ? 161.380 152.389 156.839 1.00 137.82 ? 601 NAG A C8  1 
HETATM 7558 N  N2  . NAG L 4 .   ? 159.028 151.876 156.775 1.00 142.90 ? 601 NAG A N2  1 
HETATM 7559 O  O3  . NAG L 4 .   ? 157.593 150.844 158.970 1.00 150.27 ? 601 NAG A O3  1 
HETATM 7560 O  O4  . NAG L 4 .   ? 154.982 149.854 158.383 1.00 148.74 ? 601 NAG A O4  1 
HETATM 7561 O  O5  . NAG L 4 .   ? 155.539 152.350 155.774 1.00 145.39 ? 601 NAG A O5  1 
HETATM 7562 O  O6  . NAG L 4 .   ? 153.105 152.641 157.032 1.00 143.35 ? 601 NAG A O6  1 
HETATM 7563 O  O7  . NAG L 4 .   ? 159.676 153.896 157.560 1.00 135.37 ? 601 NAG A O7  1 
HETATM 7564 C  C1  . NAG M 4 .   ? 145.434 162.662 102.947 1.00 110.20 ? 602 NAG A C1  1 
HETATM 7565 C  C2  . NAG M 4 .   ? 145.629 162.115 101.528 1.00 113.62 ? 602 NAG A C2  1 
HETATM 7566 C  C3  . NAG M 4 .   ? 146.006 160.635 101.615 1.00 116.26 ? 602 NAG A C3  1 
HETATM 7567 C  C4  . NAG M 4 .   ? 147.117 160.371 102.630 1.00 112.48 ? 602 NAG A C4  1 
HETATM 7568 C  C5  . NAG M 4 .   ? 146.837 161.101 103.946 1.00 108.18 ? 602 NAG A C5  1 
HETATM 7569 C  C6  . NAG M 4 .   ? 147.956 161.017 104.955 1.00 108.94 ? 602 NAG A C6  1 
HETATM 7570 C  C7  . NAG M 4 .   ? 143.245 161.747 100.851 1.00 115.31 ? 602 NAG A C7  1 
HETATM 7571 C  C8  . NAG M 4 .   ? 142.230 162.171 99.818  1.00 115.78 ? 602 NAG A C8  1 
HETATM 7572 N  N2  . NAG M 4 .   ? 144.461 162.318 100.706 1.00 113.91 ? 602 NAG A N2  1 
HETATM 7573 O  O3  . NAG M 4 .   ? 146.375 160.217 100.328 1.00 121.21 ? 602 NAG A O3  1 
HETATM 7574 O  O4  . NAG M 4 .   ? 147.175 158.977 102.825 1.00 107.78 ? 602 NAG A O4  1 
HETATM 7575 O  O5  . NAG M 4 .   ? 146.622 162.461 103.665 1.00 106.40 ? 602 NAG A O5  1 
HETATM 7576 O  O6  . NAG M 4 .   ? 147.800 162.045 105.903 1.00 105.98 ? 602 NAG A O6  1 
HETATM 7577 O  O7  . NAG M 4 .   ? 142.945 160.952 101.730 1.00 115.84 ? 602 NAG A O7  1 
HETATM 7578 C  C1  . NAG N 4 .   ? 144.297 185.125 119.206 1.00 97.99  ? 603 NAG A C1  1 
HETATM 7579 C  C2  . NAG N 4 .   ? 144.427 186.340 120.134 1.00 97.94  ? 603 NAG A C2  1 
HETATM 7580 C  C3  . NAG N 4 .   ? 143.797 185.999 121.481 1.00 96.85  ? 603 NAG A C3  1 
HETATM 7581 C  C4  . NAG N 4 .   ? 142.367 185.507 121.289 1.00 98.58  ? 603 NAG A C4  1 
HETATM 7582 C  C5  . NAG N 4 .   ? 142.374 184.331 120.309 1.00 97.69  ? 603 NAG A C5  1 
HETATM 7583 C  C6  . NAG N 4 .   ? 141.009 183.746 120.022 1.00 90.13  ? 603 NAG A C6  1 
HETATM 7584 C  C7  . NAG N 4 .   ? 146.317 187.909 119.975 1.00 87.70  ? 603 NAG A C7  1 
HETATM 7585 C  C8  . NAG N 4 .   ? 147.788 188.079 120.254 1.00 79.24  ? 603 NAG A C8  1 
HETATM 7586 N  N2  . NAG N 4 .   ? 145.803 186.715 120.313 1.00 91.24  ? 603 NAG A N2  1 
HETATM 7587 O  O3  . NAG N 4 .   ? 143.862 187.141 122.292 1.00 91.48  ? 603 NAG A O3  1 
HETATM 7588 O  O4  . NAG N 4 .   ? 141.883 185.128 122.556 1.00 91.93  ? 603 NAG A O4  1 
HETATM 7589 O  O5  . NAG N 4 .   ? 142.940 184.767 119.093 1.00 100.68 ? 603 NAG A O5  1 
HETATM 7590 O  O6  . NAG N 4 .   ? 140.192 184.719 119.415 1.00 91.51  ? 603 NAG A O6  1 
HETATM 7591 O  O7  . NAG N 4 .   ? 145.657 188.806 119.476 1.00 91.29  ? 603 NAG A O7  1 
HETATM 7592 C  C1  . NAG O 4 .   ? 168.052 148.598 124.081 1.00 122.84 ? 604 NAG A C1  1 
HETATM 7593 C  C2  . NAG O 4 .   ? 168.646 148.292 122.697 1.00 121.38 ? 604 NAG A C2  1 
HETATM 7594 C  C3  . NAG O 4 .   ? 168.608 146.788 122.407 1.00 125.28 ? 604 NAG A C3  1 
HETATM 7595 C  C4  . NAG O 4 .   ? 169.141 145.974 123.582 1.00 127.80 ? 604 NAG A C4  1 
HETATM 7596 C  C5  . NAG O 4 .   ? 168.504 146.447 124.892 1.00 127.88 ? 604 NAG A C5  1 
HETATM 7597 C  C6  . NAG O 4 .   ? 169.034 145.735 126.116 1.00 127.88 ? 604 NAG A C6  1 
HETATM 7598 C  C7  . NAG O 4 .   ? 166.817 149.208 121.116 1.00 117.85 ? 604 NAG A C7  1 
HETATM 7599 C  C8  . NAG O 4 .   ? 165.667 148.393 121.669 1.00 114.60 ? 604 NAG A C8  1 
HETATM 7600 N  N2  . NAG O 4 .   ? 168.070 149.089 121.631 1.00 116.67 ? 604 NAG A N2  1 
HETATM 7601 O  O3  . NAG O 4 .   ? 169.350 146.561 121.238 1.00 127.21 ? 604 NAG A O3  1 
HETATM 7602 O  O4  . NAG O 4 .   ? 168.830 144.623 123.326 1.00 120.65 ? 604 NAG A O4  1 
HETATM 7603 O  O5  . NAG O 4 .   ? 168.731 147.832 125.045 1.00 125.64 ? 604 NAG A O5  1 
HETATM 7604 O  O6  . NAG O 4 .   ? 170.432 145.879 126.177 1.00 126.96 ? 604 NAG A O6  1 
HETATM 7605 O  O7  . NAG O 4 .   ? 166.599 149.974 120.192 1.00 119.67 ? 604 NAG A O7  1 
HETATM 7606 C  C1  . NAG P 4 .   ? 189.901 150.410 121.803 1.00 168.01 ? 605 NAG A C1  1 
HETATM 7607 C  C2  . NAG P 4 .   ? 189.121 149.718 122.932 1.00 170.28 ? 605 NAG A C2  1 
HETATM 7608 C  C3  . NAG P 4 .   ? 188.896 148.239 122.614 1.00 172.67 ? 605 NAG A C3  1 
HETATM 7609 C  C4  . NAG P 4 .   ? 188.347 148.060 121.203 1.00 173.06 ? 605 NAG A C4  1 
HETATM 7610 C  C5  . NAG P 4 .   ? 189.235 148.815 120.209 1.00 172.31 ? 605 NAG A C5  1 
HETATM 7611 C  C6  . NAG P 4 .   ? 188.788 148.685 118.770 1.00 171.03 ? 605 NAG A C6  1 
HETATM 7612 C  C7  . NAG P 4 .   ? 191.027 149.492 124.535 1.00 167.33 ? 605 NAG A C7  1 
HETATM 7613 C  C8  . NAG P 4 .   ? 191.428 149.820 125.952 1.00 165.73 ? 605 NAG A C8  1 
HETATM 7614 N  N2  . NAG P 4 .   ? 189.780 149.888 124.204 1.00 168.33 ? 605 NAG A N2  1 
HETATM 7615 O  O3  . NAG P 4 .   ? 188.024 147.720 123.584 1.00 170.28 ? 605 NAG A O3  1 
HETATM 7616 O  O4  . NAG P 4 .   ? 188.326 146.676 120.935 1.00 170.89 ? 605 NAG A O4  1 
HETATM 7617 O  O5  . NAG P 4 .   ? 189.260 150.182 120.569 1.00 170.75 ? 605 NAG A O5  1 
HETATM 7618 O  O6  . NAG P 4 .   ? 187.427 149.025 118.663 1.00 169.92 ? 605 NAG A O6  1 
HETATM 7619 O  O7  . NAG P 4 .   ? 191.800 148.912 123.785 1.00 167.67 ? 605 NAG A O7  1 
HETATM 7620 C  C1  . NAG Q 4 .   ? 179.665 148.519 143.071 1.00 112.11 ? 606 NAG A C1  1 
HETATM 7621 C  C2  . NAG Q 4 .   ? 179.998 147.055 143.395 1.00 114.53 ? 606 NAG A C2  1 
HETATM 7622 C  C3  . NAG Q 4 .   ? 181.326 146.961 144.139 1.00 116.44 ? 606 NAG A C3  1 
HETATM 7623 C  C4  . NAG Q 4 .   ? 182.411 147.689 143.359 1.00 114.83 ? 606 NAG A C4  1 
HETATM 7624 C  C5  . NAG Q 4 .   ? 181.942 149.118 143.076 1.00 110.52 ? 606 NAG A C5  1 
HETATM 7625 C  C6  . NAG Q 4 .   ? 182.963 149.940 142.326 1.00 104.52 ? 606 NAG A C6  1 
HETATM 7626 C  C7  . NAG Q 4 .   ? 178.460 146.749 145.340 1.00 111.20 ? 606 NAG A C7  1 
HETATM 7627 C  C8  . NAG Q 4 .   ? 177.346 145.864 145.840 1.00 107.62 ? 606 NAG A C8  1 
HETATM 7628 N  N2  . NAG Q 4 .   ? 178.941 146.405 144.130 1.00 113.69 ? 606 NAG A N2  1 
HETATM 7629 O  O3  . NAG Q 4 .   ? 181.628 145.604 144.316 1.00 114.96 ? 606 NAG A O3  1 
HETATM 7630 O  O4  . NAG Q 4 .   ? 183.574 147.671 144.152 1.00 117.76 ? 606 NAG A O4  1 
HETATM 7631 O  O5  . NAG Q 4 .   ? 180.736 149.069 142.338 1.00 111.03 ? 606 NAG A O5  1 
HETATM 7632 O  O6  . NAG Q 4 .   ? 183.570 149.143 141.337 1.00 104.98 ? 606 NAG A O6  1 
HETATM 7633 O  O7  . NAG Q 4 .   ? 178.863 147.688 146.009 1.00 109.55 ? 606 NAG A O7  1 
HETATM 7634 C  C1  . NAG R 4 .   ? 166.895 146.501 106.847 1.00 135.67 ? 607 NAG A C1  1 
HETATM 7635 C  C2  . NAG R 4 .   ? 167.442 146.594 105.419 1.00 136.72 ? 607 NAG A C2  1 
HETATM 7636 C  C3  . NAG R 4 .   ? 166.781 145.511 104.572 1.00 134.03 ? 607 NAG A C3  1 
HETATM 7637 C  C4  . NAG R 4 .   ? 166.991 144.145 105.217 1.00 135.18 ? 607 NAG A C4  1 
HETATM 7638 C  C5  . NAG R 4 .   ? 166.523 144.185 106.676 1.00 136.68 ? 607 NAG A C5  1 
HETATM 7639 C  C6  . NAG R 4 .   ? 166.751 142.891 107.424 1.00 137.81 ? 607 NAG A C6  1 
HETATM 7640 C  C7  . NAG R 4 .   ? 168.186 148.819 104.647 1.00 131.72 ? 607 NAG A C7  1 
HETATM 7641 C  C8  . NAG R 4 .   ? 169.583 148.404 105.040 1.00 126.46 ? 607 NAG A C8  1 
HETATM 7642 N  N2  . NAG R 4 .   ? 167.224 147.901 104.860 1.00 136.07 ? 607 NAG A N2  1 
HETATM 7643 O  O3  . NAG R 4 .   ? 167.324 145.573 103.280 1.00 130.37 ? 607 NAG A O3  1 
HETATM 7644 O  O4  . NAG R 4 .   ? 166.261 143.203 104.465 1.00 129.80 ? 607 NAG A O4  1 
HETATM 7645 O  O5  . NAG R 4 .   ? 167.196 145.225 107.359 1.00 135.67 ? 607 NAG A O5  1 
HETATM 7646 O  O6  . NAG R 4 .   ? 166.512 143.092 108.797 1.00 136.81 ? 607 NAG A O6  1 
HETATM 7647 O  O7  . NAG R 4 .   ? 167.964 149.921 104.170 1.00 130.93 ? 607 NAG A O7  1 
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