data_9NJJ
# 
_entry.id   9NJJ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9NJJ         pdb_00009njj 10.2210/pdb9njj/pdb 
WWPDB D_1000292098 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-04 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9NJJ 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yi.lu@utexas.edu 
_pdbx_contact_author.name_first         Yi 
_pdbx_contact_author.name_last          Lu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1221-6709 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, J.-X.' 1 0000-0003-3381-7976 
'Lu, Y.'      2 0000-0003-1221-6709 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Chem Sci' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-6539 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Unexpected effect of an axial ligand mutation in the type 1 copper center in small laccase: structure-based analyses and engineering to increase reduction potential and activity
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1039/D5SC02177D 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wang, J.X.'     1 ? 
primary 'Vilbert, A.C.'  2 ? 
primary 'Williams, L.H.' 3 ? 
primary 'Mirts, E.N.'    4 ? 
primary 'Cui, C.'        5 ? 
primary 'Lu, Y.'         6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Copper oxidase'       37985.109 1   ? 'F195L, I200F, M298L' ? ? 
2 non-polymer syn 'COPPER (II) ION'      63.546    4   ? ?                     ? ? 
3 non-polymer syn 'HYDROXIDE ION'        17.007    1   ? ?                     ? ? 
4 non-polymer syn GLYCINE                75.067    4   ? ?                     ? ? 
5 non-polymer syn 'TETRAETHYLENE GLYCOL' 194.226   2   ? ?                     ? ? 
6 water       nat water                  18.015    149 ? ?                     ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDRRGFNRRVLLGGAAAATSLSIAPEVAGAAPAAKGITARTAPAGGEVRHLKMYAEKLADGQMGYGFEKGKASVPGPLIE
VNEGDTLHIEFTNTMDVRASLHVHGLDYEISSDGTAMNKSDVEPGGTRTYTWRTHKPGRRDDGTWRPGSAGYWHYHDHVV
GTEHGTGGIRNGLYGPVIVRRKGDVLPDATHTIVLNDMTFNNRKPHTGPDFEATVGDRVEIVMITHGEYYHTFHMHGHRW
ADNRTGILTGPDDPSRVIDNKITGPADSFGFQIIAGEGVGAGAWMYHCHVQSHSDMGLVGLFLVKKPDGTIPGYEPHEHG
GATAKSGESGEPTGGAAAHEHEHLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDRRGFNRRVLLGGAAAATSLSIAPEVAGAAPAAKGITARTAPAGGEVRHLKMYAEKLADGQMGYGFEKGKASVPGPLIE
VNEGDTLHIEFTNTMDVRASLHVHGLDYEISSDGTAMNKSDVEPGGTRTYTWRTHKPGRRDDGTWRPGSAGYWHYHDHVV
GTEHGTGGIRNGLYGPVIVRRKGDVLPDATHTIVLNDMTFNNRKPHTGPDFEATVGDRVEIVMITHGEYYHTFHMHGHRW
ADNRTGILTGPDDPSRVIDNKITGPADSFGFQIIAGEGVGAGAWMYHCHVQSHSDMGLVGLFLVKKPDGTIPGYEPHEHG
GATAKSGESGEPTGGAAAHEHEHLEHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'COPPER (II) ION'      CU  
3 'HYDROXIDE ION'        OH  
4 GLYCINE                GLY 
5 'TETRAETHYLENE GLYCOL' PG4 
6 water                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   ARG n 
1 4   ARG n 
1 5   GLY n 
1 6   PHE n 
1 7   ASN n 
1 8   ARG n 
1 9   ARG n 
1 10  VAL n 
1 11  LEU n 
1 12  LEU n 
1 13  GLY n 
1 14  GLY n 
1 15  ALA n 
1 16  ALA n 
1 17  ALA n 
1 18  ALA n 
1 19  THR n 
1 20  SER n 
1 21  LEU n 
1 22  SER n 
1 23  ILE n 
1 24  ALA n 
1 25  PRO n 
1 26  GLU n 
1 27  VAL n 
1 28  ALA n 
1 29  GLY n 
1 30  ALA n 
1 31  ALA n 
1 32  PRO n 
1 33  ALA n 
1 34  ALA n 
1 35  LYS n 
1 36  GLY n 
1 37  ILE n 
1 38  THR n 
1 39  ALA n 
1 40  ARG n 
1 41  THR n 
1 42  ALA n 
1 43  PRO n 
1 44  ALA n 
1 45  GLY n 
1 46  GLY n 
1 47  GLU n 
1 48  VAL n 
1 49  ARG n 
1 50  HIS n 
1 51  LEU n 
1 52  LYS n 
1 53  MET n 
1 54  TYR n 
1 55  ALA n 
1 56  GLU n 
1 57  LYS n 
1 58  LEU n 
1 59  ALA n 
1 60  ASP n 
1 61  GLY n 
1 62  GLN n 
1 63  MET n 
1 64  GLY n 
1 65  TYR n 
1 66  GLY n 
1 67  PHE n 
1 68  GLU n 
1 69  LYS n 
1 70  GLY n 
1 71  LYS n 
1 72  ALA n 
1 73  SER n 
1 74  VAL n 
1 75  PRO n 
1 76  GLY n 
1 77  PRO n 
1 78  LEU n 
1 79  ILE n 
1 80  GLU n 
1 81  VAL n 
1 82  ASN n 
1 83  GLU n 
1 84  GLY n 
1 85  ASP n 
1 86  THR n 
1 87  LEU n 
1 88  HIS n 
1 89  ILE n 
1 90  GLU n 
1 91  PHE n 
1 92  THR n 
1 93  ASN n 
1 94  THR n 
1 95  MET n 
1 96  ASP n 
1 97  VAL n 
1 98  ARG n 
1 99  ALA n 
1 100 SER n 
1 101 LEU n 
1 102 HIS n 
1 103 VAL n 
1 104 HIS n 
1 105 GLY n 
1 106 LEU n 
1 107 ASP n 
1 108 TYR n 
1 109 GLU n 
1 110 ILE n 
1 111 SER n 
1 112 SER n 
1 113 ASP n 
1 114 GLY n 
1 115 THR n 
1 116 ALA n 
1 117 MET n 
1 118 ASN n 
1 119 LYS n 
1 120 SER n 
1 121 ASP n 
1 122 VAL n 
1 123 GLU n 
1 124 PRO n 
1 125 GLY n 
1 126 GLY n 
1 127 THR n 
1 128 ARG n 
1 129 THR n 
1 130 TYR n 
1 131 THR n 
1 132 TRP n 
1 133 ARG n 
1 134 THR n 
1 135 HIS n 
1 136 LYS n 
1 137 PRO n 
1 138 GLY n 
1 139 ARG n 
1 140 ARG n 
1 141 ASP n 
1 142 ASP n 
1 143 GLY n 
1 144 THR n 
1 145 TRP n 
1 146 ARG n 
1 147 PRO n 
1 148 GLY n 
1 149 SER n 
1 150 ALA n 
1 151 GLY n 
1 152 TYR n 
1 153 TRP n 
1 154 HIS n 
1 155 TYR n 
1 156 HIS n 
1 157 ASP n 
1 158 HIS n 
1 159 VAL n 
1 160 VAL n 
1 161 GLY n 
1 162 THR n 
1 163 GLU n 
1 164 HIS n 
1 165 GLY n 
1 166 THR n 
1 167 GLY n 
1 168 GLY n 
1 169 ILE n 
1 170 ARG n 
1 171 ASN n 
1 172 GLY n 
1 173 LEU n 
1 174 TYR n 
1 175 GLY n 
1 176 PRO n 
1 177 VAL n 
1 178 ILE n 
1 179 VAL n 
1 180 ARG n 
1 181 ARG n 
1 182 LYS n 
1 183 GLY n 
1 184 ASP n 
1 185 VAL n 
1 186 LEU n 
1 187 PRO n 
1 188 ASP n 
1 189 ALA n 
1 190 THR n 
1 191 HIS n 
1 192 THR n 
1 193 ILE n 
1 194 VAL n 
1 195 LEU n 
1 196 ASN n 
1 197 ASP n 
1 198 MET n 
1 199 THR n 
1 200 PHE n 
1 201 ASN n 
1 202 ASN n 
1 203 ARG n 
1 204 LYS n 
1 205 PRO n 
1 206 HIS n 
1 207 THR n 
1 208 GLY n 
1 209 PRO n 
1 210 ASP n 
1 211 PHE n 
1 212 GLU n 
1 213 ALA n 
1 214 THR n 
1 215 VAL n 
1 216 GLY n 
1 217 ASP n 
1 218 ARG n 
1 219 VAL n 
1 220 GLU n 
1 221 ILE n 
1 222 VAL n 
1 223 MET n 
1 224 ILE n 
1 225 THR n 
1 226 HIS n 
1 227 GLY n 
1 228 GLU n 
1 229 TYR n 
1 230 TYR n 
1 231 HIS n 
1 232 THR n 
1 233 PHE n 
1 234 HIS n 
1 235 MET n 
1 236 HIS n 
1 237 GLY n 
1 238 HIS n 
1 239 ARG n 
1 240 TRP n 
1 241 ALA n 
1 242 ASP n 
1 243 ASN n 
1 244 ARG n 
1 245 THR n 
1 246 GLY n 
1 247 ILE n 
1 248 LEU n 
1 249 THR n 
1 250 GLY n 
1 251 PRO n 
1 252 ASP n 
1 253 ASP n 
1 254 PRO n 
1 255 SER n 
1 256 ARG n 
1 257 VAL n 
1 258 ILE n 
1 259 ASP n 
1 260 ASN n 
1 261 LYS n 
1 262 ILE n 
1 263 THR n 
1 264 GLY n 
1 265 PRO n 
1 266 ALA n 
1 267 ASP n 
1 268 SER n 
1 269 PHE n 
1 270 GLY n 
1 271 PHE n 
1 272 GLN n 
1 273 ILE n 
1 274 ILE n 
1 275 ALA n 
1 276 GLY n 
1 277 GLU n 
1 278 GLY n 
1 279 VAL n 
1 280 GLY n 
1 281 ALA n 
1 282 GLY n 
1 283 ALA n 
1 284 TRP n 
1 285 MET n 
1 286 TYR n 
1 287 HIS n 
1 288 CYS n 
1 289 HIS n 
1 290 VAL n 
1 291 GLN n 
1 292 SER n 
1 293 HIS n 
1 294 SER n 
1 295 ASP n 
1 296 MET n 
1 297 GLY n 
1 298 LEU n 
1 299 VAL n 
1 300 GLY n 
1 301 LEU n 
1 302 PHE n 
1 303 LEU n 
1 304 VAL n 
1 305 LYS n 
1 306 LYS n 
1 307 PRO n 
1 308 ASP n 
1 309 GLY n 
1 310 THR n 
1 311 ILE n 
1 312 PRO n 
1 313 GLY n 
1 314 TYR n 
1 315 GLU n 
1 316 PRO n 
1 317 HIS n 
1 318 GLU n 
1 319 HIS n 
1 320 GLY n 
1 321 GLY n 
1 322 ALA n 
1 323 THR n 
1 324 ALA n 
1 325 LYS n 
1 326 SER n 
1 327 GLY n 
1 328 GLU n 
1 329 SER n 
1 330 GLY n 
1 331 GLU n 
1 332 PRO n 
1 333 THR n 
1 334 GLY n 
1 335 GLY n 
1 336 ALA n 
1 337 ALA n 
1 338 ALA n 
1 339 HIS n 
1 340 GLU n 
1 341 HIS n 
1 342 GLU n 
1 343 HIS n 
1 344 LEU n 
1 345 GLU n 
1 346 HIS n 
1 347 HIS n 
1 348 HIS n 
1 349 HIS n 
1 350 HIS n 
1 351 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   351 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SCO6712, SC4C6.22' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces coelicolor' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1902 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE               ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE             ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'        ? 'C4 H7 N O4'     133.103 
CU  non-polymer         . 'COPPER (II) ION'      ? 'Cu 2'           63.546  
CYS 'L-peptide linking' y CYSTEINE               ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE              ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'        ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE              ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                  ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE             ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                 ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE             ? 'C5 H11 N O2 S'  149.211 
OH  non-polymer         . 'HYDROXIDE ION'        ? 'H O -1'         17.007  
PG4 non-polymer         . 'TETRAETHYLENE GLYCOL' ? 'C8 H18 O5'      194.226 
PHE 'L-peptide linking' y PHENYLALANINE          ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                 ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE              ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN             ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE               ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                 ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   ARG 3   3   ?   ?   ?   A . n 
A 1 4   ARG 4   4   ?   ?   ?   A . n 
A 1 5   GLY 5   5   ?   ?   ?   A . n 
A 1 6   PHE 6   6   ?   ?   ?   A . n 
A 1 7   ASN 7   7   ?   ?   ?   A . n 
A 1 8   ARG 8   8   ?   ?   ?   A . n 
A 1 9   ARG 9   9   ?   ?   ?   A . n 
A 1 10  VAL 10  10  ?   ?   ?   A . n 
A 1 11  LEU 11  11  ?   ?   ?   A . n 
A 1 12  LEU 12  12  ?   ?   ?   A . n 
A 1 13  GLY 13  13  ?   ?   ?   A . n 
A 1 14  GLY 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  ?   ?   ?   A . n 
A 1 16  ALA 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  ALA 18  18  ?   ?   ?   A . n 
A 1 19  THR 19  19  ?   ?   ?   A . n 
A 1 20  SER 20  20  ?   ?   ?   A . n 
A 1 21  LEU 21  21  ?   ?   ?   A . n 
A 1 22  SER 22  22  ?   ?   ?   A . n 
A 1 23  ILE 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  PRO 25  25  ?   ?   ?   A . n 
A 1 26  GLU 26  26  ?   ?   ?   A . n 
A 1 27  VAL 27  27  ?   ?   ?   A . n 
A 1 28  ALA 28  28  ?   ?   ?   A . n 
A 1 29  GLY 29  29  ?   ?   ?   A . n 
A 1 30  ALA 30  30  ?   ?   ?   A . n 
A 1 31  ALA 31  31  ?   ?   ?   A . n 
A 1 32  PRO 32  32  ?   ?   ?   A . n 
A 1 33  ALA 33  33  ?   ?   ?   A . n 
A 1 34  ALA 34  34  ?   ?   ?   A . n 
A 1 35  LYS 35  35  ?   ?   ?   A . n 
A 1 36  GLY 36  36  ?   ?   ?   A . n 
A 1 37  ILE 37  37  37  ILE ILE A . n 
A 1 38  THR 38  38  38  THR THR A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  PRO 43  43  43  PRO PRO A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  GLY 45  45  45  GLY GLY A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  HIS 50  50  50  HIS HIS A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  LYS 52  52  52  LYS LYS A . n 
A 1 53  MET 53  53  53  MET MET A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  GLU 56  56  56  GLU GLU A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ALA 59  59  59  ALA ALA A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  MET 63  63  63  MET MET A . n 
A 1 64  GLY 64  64  64  GLY GLY A . n 
A 1 65  TYR 65  65  65  TYR TYR A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  PHE 67  67  67  PHE PHE A . n 
A 1 68  GLU 68  68  68  GLU GLU A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  LYS 71  71  71  LYS LYS A . n 
A 1 72  ALA 72  72  72  ALA ALA A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  VAL 74  74  74  VAL VAL A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  PRO 77  77  77  PRO PRO A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  GLU 80  80  80  GLU GLU A . n 
A 1 81  VAL 81  81  81  VAL VAL A . n 
A 1 82  ASN 82  82  82  ASN ASN A . n 
A 1 83  GLU 83  83  83  GLU GLU A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ASP 85  85  85  ASP ASP A . n 
A 1 86  THR 86  86  86  THR THR A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  HIS 88  88  88  HIS HIS A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  GLU 90  90  90  GLU GLU A . n 
A 1 91  PHE 91  91  91  PHE PHE A . n 
A 1 92  THR 92  92  92  THR THR A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  THR 94  94  94  THR THR A . n 
A 1 95  MET 95  95  95  MET MET A . n 
A 1 96  ASP 96  96  96  ASP ASP A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  ALA 99  99  99  ALA ALA A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 LEU 101 101 101 LEU LEU A . n 
A 1 102 HIS 102 102 102 HIS HIS A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 HIS 104 104 104 HIS HIS A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 ASP 107 107 107 ASP ASP A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 SER 111 111 111 SER SER A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 MET 117 117 117 MET MET A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 LYS 119 119 119 LYS LYS A . n 
A 1 120 SER 120 120 120 SER SER A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 THR 127 127 127 THR THR A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 THR 129 129 129 THR THR A . n 
A 1 130 TYR 130 130 130 TYR TYR A . n 
A 1 131 THR 131 131 131 THR THR A . n 
A 1 132 TRP 132 132 132 TRP TRP A . n 
A 1 133 ARG 133 133 133 ARG ARG A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 HIS 135 135 135 HIS HIS A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 PRO 137 137 137 PRO PRO A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 ARG 139 139 139 ARG ARG A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 ASP 141 141 141 ASP ASP A . n 
A 1 142 ASP 142 142 142 ASP ASP A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 TRP 145 145 145 TRP TRP A . n 
A 1 146 ARG 146 146 146 ARG ARG A . n 
A 1 147 PRO 147 147 147 PRO PRO A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 SER 149 149 149 SER SER A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 GLY 151 151 151 GLY GLY A . n 
A 1 152 TYR 152 152 152 TYR TYR A . n 
A 1 153 TRP 153 153 153 TRP TRP A . n 
A 1 154 HIS 154 154 154 HIS HIS A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 HIS 156 156 156 HIS HIS A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 HIS 158 158 158 HIS HIS A . n 
A 1 159 VAL 159 159 159 VAL VAL A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 GLU 163 163 163 GLU GLU A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 ILE 169 169 169 ILE ILE A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ASN 171 171 171 ASN ASN A . n 
A 1 172 GLY 172 172 172 GLY GLY A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 TYR 174 174 174 TYR TYR A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 PRO 176 176 176 PRO PRO A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 VAL 179 179 179 VAL VAL A . n 
A 1 180 ARG 180 180 180 ARG ARG A . n 
A 1 181 ARG 181 181 181 ARG ARG A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 ASP 184 184 184 ASP ASP A . n 
A 1 185 VAL 185 185 185 VAL VAL A . n 
A 1 186 LEU 186 186 186 LEU LEU A . n 
A 1 187 PRO 187 187 187 PRO PRO A . n 
A 1 188 ASP 188 188 188 ASP ASP A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 HIS 191 191 191 HIS HIS A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 VAL 194 194 194 VAL VAL A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 ASN 196 196 196 ASN ASN A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 PHE 200 200 200 PHE PHE A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 ASN 202 202 202 ASN ASN A . n 
A 1 203 ARG 203 203 203 ARG ARG A . n 
A 1 204 LYS 204 204 204 LYS LYS A . n 
A 1 205 PRO 205 205 205 PRO PRO A . n 
A 1 206 HIS 206 206 206 HIS HIS A . n 
A 1 207 THR 207 207 207 THR THR A . n 
A 1 208 GLY 208 208 208 GLY GLY A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 GLY 216 216 216 GLY GLY A . n 
A 1 217 ASP 217 217 217 ASP ASP A . n 
A 1 218 ARG 218 218 218 ARG ARG A . n 
A 1 219 VAL 219 219 219 VAL VAL A . n 
A 1 220 GLU 220 220 220 GLU GLU A . n 
A 1 221 ILE 221 221 221 ILE ILE A . n 
A 1 222 VAL 222 222 222 VAL VAL A . n 
A 1 223 MET 223 223 223 MET MET A . n 
A 1 224 ILE 224 224 224 ILE ILE A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 HIS 226 226 226 HIS HIS A . n 
A 1 227 GLY 227 227 227 GLY GLY A . n 
A 1 228 GLU 228 228 228 GLU GLU A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 TYR 230 230 230 TYR TYR A . n 
A 1 231 HIS 231 231 231 HIS HIS A . n 
A 1 232 THR 232 232 232 THR THR A . n 
A 1 233 PHE 233 233 233 PHE PHE A . n 
A 1 234 HIS 234 234 234 HIS HIS A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 HIS 238 238 238 HIS HIS A . n 
A 1 239 ARG 239 239 239 ARG ARG A . n 
A 1 240 TRP 240 240 240 TRP TRP A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 ASP 242 242 242 ASP ASP A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 ARG 244 244 244 ARG ARG A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 GLY 246 246 246 GLY GLY A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 THR 249 249 249 THR THR A . n 
A 1 250 GLY 250 250 250 GLY GLY A . n 
A 1 251 PRO 251 251 251 PRO PRO A . n 
A 1 252 ASP 252 252 252 ASP ASP A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 PRO 254 254 254 PRO PRO A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 VAL 257 257 257 VAL VAL A . n 
A 1 258 ILE 258 258 258 ILE ILE A . n 
A 1 259 ASP 259 259 259 ASP ASP A . n 
A 1 260 ASN 260 260 260 ASN ASN A . n 
A 1 261 LYS 261 261 261 LYS LYS A . n 
A 1 262 ILE 262 262 262 ILE ILE A . n 
A 1 263 THR 263 263 263 THR THR A . n 
A 1 264 GLY 264 264 264 GLY GLY A . n 
A 1 265 PRO 265 265 265 PRO PRO A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 SER 268 268 268 SER SER A . n 
A 1 269 PHE 269 269 269 PHE PHE A . n 
A 1 270 GLY 270 270 270 GLY GLY A . n 
A 1 271 PHE 271 271 271 PHE PHE A . n 
A 1 272 GLN 272 272 272 GLN GLN A . n 
A 1 273 ILE 273 273 273 ILE ILE A . n 
A 1 274 ILE 274 274 274 ILE ILE A . n 
A 1 275 ALA 275 275 275 ALA ALA A . n 
A 1 276 GLY 276 276 276 GLY GLY A . n 
A 1 277 GLU 277 277 277 GLU GLU A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 VAL 279 279 279 VAL VAL A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 GLY 282 282 282 GLY GLY A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 TRP 284 284 284 TRP TRP A . n 
A 1 285 MET 285 285 285 MET MET A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 HIS 287 287 287 HIS HIS A . n 
A 1 288 CYS 288 288 288 CYS CYS A . n 
A 1 289 HIS 289 289 289 HIS HIS A . n 
A 1 290 VAL 290 290 290 VAL VAL A . n 
A 1 291 GLN 291 291 291 GLN GLN A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 HIS 293 293 293 HIS HIS A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 MET 296 296 296 MET MET A . n 
A 1 297 GLY 297 297 297 GLY GLY A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 VAL 299 299 299 VAL VAL A . n 
A 1 300 GLY 300 300 300 GLY GLY A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 PHE 302 302 302 PHE PHE A . n 
A 1 303 LEU 303 303 303 LEU LEU A . n 
A 1 304 VAL 304 304 304 VAL VAL A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 LYS 306 306 306 LYS LYS A . n 
A 1 307 PRO 307 307 307 PRO PRO A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 GLY 309 309 309 GLY GLY A . n 
A 1 310 THR 310 310 310 THR THR A . n 
A 1 311 ILE 311 311 311 ILE ILE A . n 
A 1 312 PRO 312 312 312 PRO PRO A . n 
A 1 313 GLY 313 313 313 GLY GLY A . n 
A 1 314 TYR 314 314 314 TYR TYR A . n 
A 1 315 GLU 315 315 ?   ?   ?   A . n 
A 1 316 PRO 316 316 ?   ?   ?   A . n 
A 1 317 HIS 317 317 ?   ?   ?   A . n 
A 1 318 GLU 318 318 ?   ?   ?   A . n 
A 1 319 HIS 319 319 ?   ?   ?   A . n 
A 1 320 GLY 320 320 ?   ?   ?   A . n 
A 1 321 GLY 321 321 ?   ?   ?   A . n 
A 1 322 ALA 322 322 ?   ?   ?   A . n 
A 1 323 THR 323 323 ?   ?   ?   A . n 
A 1 324 ALA 324 324 ?   ?   ?   A . n 
A 1 325 LYS 325 325 ?   ?   ?   A . n 
A 1 326 SER 326 326 ?   ?   ?   A . n 
A 1 327 GLY 327 327 ?   ?   ?   A . n 
A 1 328 GLU 328 328 ?   ?   ?   A . n 
A 1 329 SER 329 329 ?   ?   ?   A . n 
A 1 330 GLY 330 330 ?   ?   ?   A . n 
A 1 331 GLU 331 331 ?   ?   ?   A . n 
A 1 332 PRO 332 332 ?   ?   ?   A . n 
A 1 333 THR 333 333 ?   ?   ?   A . n 
A 1 334 GLY 334 334 ?   ?   ?   A . n 
A 1 335 GLY 335 335 ?   ?   ?   A . n 
A 1 336 ALA 336 336 ?   ?   ?   A . n 
A 1 337 ALA 337 337 ?   ?   ?   A . n 
A 1 338 ALA 338 338 ?   ?   ?   A . n 
A 1 339 HIS 339 339 ?   ?   ?   A . n 
A 1 340 GLU 340 340 ?   ?   ?   A . n 
A 1 341 HIS 341 341 ?   ?   ?   A . n 
A 1 342 GLU 342 342 ?   ?   ?   A . n 
A 1 343 HIS 343 343 ?   ?   ?   A . n 
A 1 344 LEU 344 344 ?   ?   ?   A . n 
A 1 345 GLU 345 345 ?   ?   ?   A . n 
A 1 346 HIS 346 346 ?   ?   ?   A . n 
A 1 347 HIS 347 347 ?   ?   ?   A . n 
A 1 348 HIS 348 348 ?   ?   ?   A . n 
A 1 349 HIS 349 349 ?   ?   ?   A . n 
A 1 350 HIS 350 350 ?   ?   ?   A . n 
A 1 351 HIS 351 351 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CU ? ? CU ? ? 'SUBJECT OF INVESTIGATION' ? 
2 OH ? ? OH ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CU  1   401 411 CU  CU  A . 
C 2 CU  1   402 412 CU  CU  A . 
D 2 CU  1   403 413 CU  CU  A . 
E 2 CU  1   404 414 CU  CU  A . 
F 3 OH  1   405 501 OH  OH  A . 
G 4 GLY 1   406 502 GLY GLY A . 
H 4 GLY 1   407 601 GLY GLY A . 
I 5 PG4 1   408 701 PG4 PG4 A . 
J 5 PG4 1   409 702 PG4 PG4 A . 
K 4 GLY 1   410 703 GLY GLY A . 
L 4 GLY 1   411 801 GLY GLY A . 
M 6 HOH 1   501 50  HOH HOH A . 
M 6 HOH 2   502 160 HOH HOH A . 
M 6 HOH 3   503 146 HOH HOH A . 
M 6 HOH 4   504 134 HOH HOH A . 
M 6 HOH 5   505 4   HOH HOH A . 
M 6 HOH 6   506 64  HOH HOH A . 
M 6 HOH 7   507 9   HOH HOH A . 
M 6 HOH 8   508 107 HOH HOH A . 
M 6 HOH 9   509 25  HOH HOH A . 
M 6 HOH 10  510 11  HOH HOH A . 
M 6 HOH 11  511 37  HOH HOH A . 
M 6 HOH 12  512 72  HOH HOH A . 
M 6 HOH 13  513 131 HOH HOH A . 
M 6 HOH 14  514 28  HOH HOH A . 
M 6 HOH 15  515 39  HOH HOH A . 
M 6 HOH 16  516 108 HOH HOH A . 
M 6 HOH 17  517 3   HOH HOH A . 
M 6 HOH 18  518 6   HOH HOH A . 
M 6 HOH 19  519 16  HOH HOH A . 
M 6 HOH 20  520 43  HOH HOH A . 
M 6 HOH 21  521 51  HOH HOH A . 
M 6 HOH 22  522 18  HOH HOH A . 
M 6 HOH 23  523 35  HOH HOH A . 
M 6 HOH 24  524 12  HOH HOH A . 
M 6 HOH 25  525 53  HOH HOH A . 
M 6 HOH 26  526 21  HOH HOH A . 
M 6 HOH 27  527 17  HOH HOH A . 
M 6 HOH 28  528 7   HOH HOH A . 
M 6 HOH 29  529 103 HOH HOH A . 
M 6 HOH 30  530 22  HOH HOH A . 
M 6 HOH 31  531 109 HOH HOH A . 
M 6 HOH 32  532 54  HOH HOH A . 
M 6 HOH 33  533 130 HOH HOH A . 
M 6 HOH 34  534 124 HOH HOH A . 
M 6 HOH 35  535 46  HOH HOH A . 
M 6 HOH 36  536 159 HOH HOH A . 
M 6 HOH 37  537 23  HOH HOH A . 
M 6 HOH 38  538 98  HOH HOH A . 
M 6 HOH 39  539 38  HOH HOH A . 
M 6 HOH 40  540 151 HOH HOH A . 
M 6 HOH 41  541 66  HOH HOH A . 
M 6 HOH 42  542 77  HOH HOH A . 
M 6 HOH 43  543 33  HOH HOH A . 
M 6 HOH 44  544 2   HOH HOH A . 
M 6 HOH 45  545 5   HOH HOH A . 
M 6 HOH 46  546 106 HOH HOH A . 
M 6 HOH 47  547 27  HOH HOH A . 
M 6 HOH 48  548 14  HOH HOH A . 
M 6 HOH 49  549 31  HOH HOH A . 
M 6 HOH 50  550 81  HOH HOH A . 
M 6 HOH 51  551 84  HOH HOH A . 
M 6 HOH 52  552 19  HOH HOH A . 
M 6 HOH 53  553 29  HOH HOH A . 
M 6 HOH 54  554 76  HOH HOH A . 
M 6 HOH 55  555 26  HOH HOH A . 
M 6 HOH 56  556 135 HOH HOH A . 
M 6 HOH 57  557 127 HOH HOH A . 
M 6 HOH 58  558 36  HOH HOH A . 
M 6 HOH 59  559 15  HOH HOH A . 
M 6 HOH 60  560 117 HOH HOH A . 
M 6 HOH 61  561 41  HOH HOH A . 
M 6 HOH 62  562 30  HOH HOH A . 
M 6 HOH 63  563 87  HOH HOH A . 
M 6 HOH 64  564 129 HOH HOH A . 
M 6 HOH 65  565 143 HOH HOH A . 
M 6 HOH 66  566 20  HOH HOH A . 
M 6 HOH 67  567 52  HOH HOH A . 
M 6 HOH 68  568 89  HOH HOH A . 
M 6 HOH 69  569 74  HOH HOH A . 
M 6 HOH 70  570 65  HOH HOH A . 
M 6 HOH 71  571 60  HOH HOH A . 
M 6 HOH 72  572 136 HOH HOH A . 
M 6 HOH 73  573 10  HOH HOH A . 
M 6 HOH 74  574 44  HOH HOH A . 
M 6 HOH 75  575 113 HOH HOH A . 
M 6 HOH 76  576 78  HOH HOH A . 
M 6 HOH 77  577 61  HOH HOH A . 
M 6 HOH 78  578 101 HOH HOH A . 
M 6 HOH 79  579 45  HOH HOH A . 
M 6 HOH 80  580 158 HOH HOH A . 
M 6 HOH 81  581 75  HOH HOH A . 
M 6 HOH 82  582 141 HOH HOH A . 
M 6 HOH 83  583 73  HOH HOH A . 
M 6 HOH 84  584 8   HOH HOH A . 
M 6 HOH 85  585 79  HOH HOH A . 
M 6 HOH 86  586 123 HOH HOH A . 
M 6 HOH 87  587 155 HOH HOH A . 
M 6 HOH 88  588 125 HOH HOH A . 
M 6 HOH 89  589 95  HOH HOH A . 
M 6 HOH 90  590 93  HOH HOH A . 
M 6 HOH 91  591 90  HOH HOH A . 
M 6 HOH 92  592 86  HOH HOH A . 
M 6 HOH 93  593 102 HOH HOH A . 
M 6 HOH 94  594 32  HOH HOH A . 
M 6 HOH 95  595 100 HOH HOH A . 
M 6 HOH 96  596 144 HOH HOH A . 
M 6 HOH 97  597 104 HOH HOH A . 
M 6 HOH 98  598 118 HOH HOH A . 
M 6 HOH 99  599 105 HOH HOH A . 
M 6 HOH 100 600 112 HOH HOH A . 
M 6 HOH 101 601 96  HOH HOH A . 
M 6 HOH 102 602 139 HOH HOH A . 
M 6 HOH 103 603 68  HOH HOH A . 
M 6 HOH 104 604 85  HOH HOH A . 
M 6 HOH 105 605 57  HOH HOH A . 
M 6 HOH 106 606 13  HOH HOH A . 
M 6 HOH 107 607 94  HOH HOH A . 
M 6 HOH 108 608 55  HOH HOH A . 
M 6 HOH 109 609 149 HOH HOH A . 
M 6 HOH 110 610 99  HOH HOH A . 
M 6 HOH 111 611 62  HOH HOH A . 
M 6 HOH 112 612 138 HOH HOH A . 
M 6 HOH 113 613 97  HOH HOH A . 
M 6 HOH 114 614 110 HOH HOH A . 
M 6 HOH 115 615 116 HOH HOH A . 
M 6 HOH 116 616 140 HOH HOH A . 
M 6 HOH 117 617 88  HOH HOH A . 
M 6 HOH 118 618 119 HOH HOH A . 
M 6 HOH 119 619 126 HOH HOH A . 
M 6 HOH 120 620 157 HOH HOH A . 
M 6 HOH 121 621 63  HOH HOH A . 
M 6 HOH 122 622 121 HOH HOH A . 
M 6 HOH 123 623 132 HOH HOH A . 
M 6 HOH 124 624 80  HOH HOH A . 
M 6 HOH 125 625 47  HOH HOH A . 
M 6 HOH 126 626 56  HOH HOH A . 
M 6 HOH 127 627 111 HOH HOH A . 
M 6 HOH 128 628 133 HOH HOH A . 
M 6 HOH 129 629 91  HOH HOH A . 
M 6 HOH 130 630 82  HOH HOH A . 
M 6 HOH 131 631 115 HOH HOH A . 
M 6 HOH 132 632 145 HOH HOH A . 
M 6 HOH 133 633 153 HOH HOH A . 
M 6 HOH 134 634 70  HOH HOH A . 
M 6 HOH 135 635 152 HOH HOH A . 
M 6 HOH 136 636 83  HOH HOH A . 
M 6 HOH 137 637 67  HOH HOH A . 
M 6 HOH 138 638 150 HOH HOH A . 
M 6 HOH 139 639 128 HOH HOH A . 
M 6 HOH 140 640 120 HOH HOH A . 
M 6 HOH 141 641 137 HOH HOH A . 
M 6 HOH 142 642 92  HOH HOH A . 
M 6 HOH 143 643 58  HOH HOH A . 
M 6 HOH 144 644 154 HOH HOH A . 
M 6 HOH 145 645 69  HOH HOH A . 
M 6 HOH 146 646 156 HOH HOH A . 
M 6 HOH 147 647 114 HOH HOH A . 
M 6 HOH 148 648 71  HOH HOH A . 
M 6 HOH 149 649 142 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? BOS    ? ? ? .           1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           2 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 3 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 4 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9NJJ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     177.832 
_cell.length_a_esd                 ? 
_cell.length_b                     177.832 
_cell.length_b_esd                 ? 
_cell.length_c                     177.832 
_cell.length_c_esd                 ? 
_cell.volume                       5623798.331 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9NJJ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                212 
_symmetry.space_group_name_Hall            'P 4acd 2ab 3' 
_symmetry.space_group_name_H-M             'P 43 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9NJJ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          ? 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              9 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Crystals were prepared using hanging drop vapor-diffusion technique at room temperature (~296 K). Protein is at a concentration of 18.5 mg/ml in 50 mM H3BO3, 0.1 M NaCl, pH 9.0 buffer. The well buffer contains 0.1 M glycine, 0.5 M NaCl, pH 9.0, and 37-40% (v/v) PEG (polyethylene glycol) monomethyl ether 550. 500 uL of well buffer is added to each well and protein is mixed with well buffer at a 1.5 uL:1.5 uL ratio. The crystal growth time was ca. 1 week.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            296 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Si(111)' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000006 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 8.2.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000006 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   8.2.1 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          58.18 
_reflns.entry_id                                       9NJJ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.64 
_reflns.d_resolution_low                               79.53 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     28814 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.96 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                39.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.58 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.2751 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.2716 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.64 
_reflns_shell.d_res_low                                     2.734 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.69 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2808 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               39.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               2.94 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.849 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.93 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.903 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.86 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9NJJ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.64 
_refine.ls_d_res_low                             79.53 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     28806 
_refine.ls_number_reflns_R_free                  2809 
_refine.ls_number_reflns_R_work                  50551 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.96 
_refine.ls_percent_reflns_R_free                 5.26 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1867 
_refine.ls_R_factor_R_free                       0.2077 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1855 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.8348 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3126 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.64 
_refine_hist.d_res_low                        79.53 
_refine_hist.number_atoms_solvent             149 
_refine_hist.number_atoms_total               2350 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2150 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         51 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0021 ? 2270 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.4769 ? 3068 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0452 ? 314  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0043 ? 405  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.1942 ? 326  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.64 2.69  . . 122 2560 99.93  . . . . 0.3240 . . . . . . . . . . . . . . . 0.2943 
'X-RAY DIFFRACTION' 2.69 2.73  . . 138 2499 99.92  . . . . 0.2872 . . . . . . . . . . . . . . . 0.3495 
'X-RAY DIFFRACTION' 2.73 2.79  . . 118 2538 99.96  . . . . 0.2594 . . . . . . . . . . . . . . . 0.2756 
'X-RAY DIFFRACTION' 2.79 2.84  . . 152 2513 100.00 . . . . 0.2358 . . . . . . . . . . . . . . . 0.2485 
'X-RAY DIFFRACTION' 2.84 2.91  . . 157 2549 100.00 . . . . 0.2123 . . . . . . . . . . . . . . . 0.2475 
'X-RAY DIFFRACTION' 2.91 2.97  . . 138 2513 100.00 . . . . 0.2128 . . . . . . . . . . . . . . . 0.2223 
'X-RAY DIFFRACTION' 2.97 3.05  . . 139 2511 100.00 . . . . 0.1864 . . . . . . . . . . . . . . . 0.2098 
'X-RAY DIFFRACTION' 3.05 3.13  . . 122 2554 100.00 . . . . 0.1926 . . . . . . . . . . . . . . . 0.2176 
'X-RAY DIFFRACTION' 3.13 3.22  . . 146 2525 100.00 . . . . 0.1934 . . . . . . . . . . . . . . . 0.2578 
'X-RAY DIFFRACTION' 3.22 3.33  . . 129 2541 100.00 . . . . 0.1974 . . . . . . . . . . . . . . . 0.2133 
'X-RAY DIFFRACTION' 3.33 3.44  . . 166 2516 100.00 . . . . 0.2068 . . . . . . . . . . . . . . . 0.2645 
'X-RAY DIFFRACTION' 3.45 3.58  . . 174 2488 100.00 . . . . 0.1714 . . . . . . . . . . . . . . . 0.1929 
'X-RAY DIFFRACTION' 3.58 3.75  . . 152 2502 100.00 . . . . 0.1642 . . . . . . . . . . . . . . . 0.1761 
'X-RAY DIFFRACTION' 3.75 3.94  . . 137 2548 100.00 . . . . 0.1657 . . . . . . . . . . . . . . . 0.1874 
'X-RAY DIFFRACTION' 3.94 4.19  . . 124 2552 100.00 . . . . 0.1584 . . . . . . . . . . . . . . . 0.2144 
'X-RAY DIFFRACTION' 4.19 4.51  . . 139 2515 100.00 . . . . 0.1507 . . . . . . . . . . . . . . . 0.1468 
'X-RAY DIFFRACTION' 4.52 4.97  . . 123 2550 100.00 . . . . 0.1583 . . . . . . . . . . . . . . . 0.1757 
'X-RAY DIFFRACTION' 4.97 5.69  . . 153 2521 100.00 . . . . 0.1711 . . . . . . . . . . . . . . . 0.1838 
'X-RAY DIFFRACTION' 5.69 7.16  . . 126 2538 100.00 . . . . 0.1964 . . . . . . . . . . . . . . . 0.2063 
'X-RAY DIFFRACTION' 7.17 79.53 . . 154 2518 99.48  . . . . 0.2138 . . . . . . . . . . . . . . . 0.2361 
# 
_struct.entry_id                     9NJJ 
_struct.title                        'F195L/I200F/M298L Streptomyces coelicolor Laccase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9NJJ 
_struct_keywords.text            'Laccase, Copper, Oxidoreductase' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
K N N 4 ? 
L N N 4 ? 
M N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9XAL8_STRCO 
_struct_ref.pdbx_db_accession          Q9XAL8 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDRRGFNRRVLLGGAAAATSLSIAPEVAGAAPAAKGITARTAPAGGEVRHLKMYAEKLADGQMGYGFEKGKASVPGPLIE
VNEGDTLHIEFTNTMDVRASLHVHGLDYEISSDGTAMNKSDVEPGGTRTYTWRTHKPGRRDDGTWRPGSAGYWHYHDHVV
GTEHGTGGIRNGLYGPVIVRRKGDVLPDATHTIVFNDMTINNRKPHTGPDFEATVGDRVEIVMITHGEYYHTFHMHGHRW
ADNRTGILTGPDDPSRVIDNKITGPADSFGFQIIAGEGVGAGAWMYHCHVQSHSDMGMVGLFLVKKPDGTIPGYEPHEHG
GATAKSGESGEPTGGAAAHEHEH
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9NJJ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 343 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9XAL8 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  343 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       343 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9NJJ LEU A 195 ? UNP Q9XAL8 PHE 195 'engineered mutation' 195 1  
1 9NJJ PHE A 200 ? UNP Q9XAL8 ILE 200 'engineered mutation' 200 2  
1 9NJJ LEU A 298 ? UNP Q9XAL8 MET 298 'engineered mutation' 298 3  
1 9NJJ LEU A 344 ? UNP Q9XAL8 ?   ?   'expression tag'      344 4  
1 9NJJ GLU A 345 ? UNP Q9XAL8 ?   ?   'expression tag'      345 5  
1 9NJJ HIS A 346 ? UNP Q9XAL8 ?   ?   'expression tag'      346 6  
1 9NJJ HIS A 347 ? UNP Q9XAL8 ?   ?   'expression tag'      347 7  
1 9NJJ HIS A 348 ? UNP Q9XAL8 ?   ?   'expression tag'      348 8  
1 9NJJ HIS A 349 ? UNP Q9XAL8 ?   ?   'expression tag'      349 9  
1 9NJJ HIS A 350 ? UNP Q9XAL8 ?   ?   'expression tag'      350 10 
1 9NJJ HIS A 351 ? UNP Q9XAL8 ?   ?   'expression tag'      351 11 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,C,D,E,F,G,H,I,J,K,L,M 
1 2 A,B,C,D,E,F,G,H,I,J,K,L,M 
1 3 A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 5_555 z,x,y 0.0000000000 0.0000000000 1.0000000000 0.0000000000 1.0000000000 0.0000000000 
0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 
3 'crystal symmetry operation' 9_555 y,z,x 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 
1.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 GLU A 109 ? ASP A 113 ? GLU A 109 ASP A 113 5 ? 5 
HELX_P HELX_P2 AA2 GLY A 165 ? GLY A 172 ? GLY A 165 GLY A 172 1 ? 8 
HELX_P HELX_P3 AA3 VAL A 290 ? GLY A 297 ? VAL A 290 GLY A 297 1 ? 8 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 102 NE2 ? ? ? 1_555 E CU  . CU ? ? A HIS 102 A CU  404 5_555 ? ? ? ? ? ? ? 1.881 ? ? 
metalc2  metalc ? ? A HIS 104 NE2 ? ? ? 1_555 C CU  . CU ? ? A HIS 104 A CU  402 5_555 ? ? ? ? ? ? ? 2.042 ? ? 
metalc3  metalc ? ? A HIS 156 NE2 ? ? ? 1_555 C CU  . CU ? ? A HIS 156 A CU  402 5_555 ? ? ? ? ? ? ? 2.058 ? ? 
metalc4  metalc ? ? A HIS 158 NE2 ? ? ? 1_555 D CU  . CU ? ? A HIS 158 A CU  403 5_555 ? ? ? ? ? ? ? 2.169 ? ? 
metalc5  metalc ? ? A HIS 231 ND1 ? ? ? 1_555 B CU  . CU ? ? A HIS 231 A CU  401 1_555 ? ? ? ? ? ? ? 2.104 ? ? 
metalc6  metalc ? ? A HIS 234 NE2 ? ? ? 1_555 E CU  . CU ? ? A HIS 234 A CU  404 1_555 ? ? ? ? ? ? ? 1.868 ? ? 
metalc7  metalc ? ? A HIS 236 NE2 ? ? ? 1_555 D CU  . CU ? ? A HIS 236 A CU  403 1_555 ? ? ? ? ? ? ? 2.054 ? ? 
metalc8  metalc ? ? A HIS 287 NE2 ? ? ? 1_555 D CU  . CU ? ? A HIS 287 A CU  403 1_555 ? ? ? ? ? ? ? 2.218 ? ? 
metalc9  metalc ? ? A CYS 288 SG  ? ? ? 1_555 B CU  . CU ? ? A CYS 288 A CU  401 1_555 ? ? ? ? ? ? ? 2.233 ? ? 
metalc10 metalc ? ? A HIS 289 NE2 ? ? ? 1_555 C CU  . CU ? ? A HIS 289 A CU  402 1_555 ? ? ? ? ? ? ? 2.120 ? ? 
metalc11 metalc ? ? A HIS 293 ND1 ? ? ? 1_555 B CU  . CU ? ? A HIS 293 A CU  401 1_555 ? ? ? ? ? ? ? 2.070 ? ? 
metalc12 metalc ? ? B CU  .   CU  ? ? ? 1_555 M HOH . O  B ? A CU  401 A HOH 536 1_555 ? ? ? ? ? ? ? 2.687 ? ? 
metalc13 metalc ? ? C CU  .   CU  ? ? ? 1_555 F OH  . O  ? ? A CU  402 A OH  405 1_555 ? ? ? ? ? ? ? 2.523 ? ? 
metalc14 metalc ? ? D CU  .   CU  ? ? ? 1_555 F OH  . O  ? ? A CU  403 A OH  405 1_555 ? ? ? ? ? ? ? 2.363 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 102 ? A HIS 102 ? 1_555 CU ? E CU . ? A CU 404 ? 5_555 NE2 ? A HIS 234 ? A HIS 234 ? 1_555 126.3 ? 
2  NE2 ? A HIS 104 ? A HIS 104 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 NE2 ? A HIS 156 ? A HIS 156 ? 1_555 106.5 ? 
3  NE2 ? A HIS 104 ? A HIS 104 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 NE2 ? A HIS 289 ? A HIS 289 ? 1_555 78.5  ? 
4  NE2 ? A HIS 156 ? A HIS 156 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 NE2 ? A HIS 289 ? A HIS 289 ? 1_555 99.1  ? 
5  NE2 ? A HIS 104 ? A HIS 104 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 76.5  ? 
6  NE2 ? A HIS 156 ? A HIS 156 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 95.3  ? 
7  NE2 ? A HIS 289 ? A HIS 289 ? 1_555 CU ? C CU . ? A CU 402 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 5.0   ? 
8  NE2 ? A HIS 158 ? A HIS 158 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 NE2 ? A HIS 236 ? A HIS 236 ? 1_555 108.0 ? 
9  NE2 ? A HIS 158 ? A HIS 158 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 NE2 ? A HIS 287 ? A HIS 287 ? 1_555 106.9 ? 
10 NE2 ? A HIS 236 ? A HIS 236 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 NE2 ? A HIS 287 ? A HIS 287 ? 1_555 3.6   ? 
11 NE2 ? A HIS 158 ? A HIS 158 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 112.0 ? 
12 NE2 ? A HIS 236 ? A HIS 236 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 5.9   ? 
13 NE2 ? A HIS 287 ? A HIS 287 ? 1_555 CU ? D CU . ? A CU 403 ? 5_555 O   ? F OH  .   ? A OH  405 ? 1_555 5.2   ? 
14 ND1 ? A HIS 231 ? A HIS 231 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 SG  ? A CYS 288 ? A CYS 288 ? 1_555 135.8 ? 
15 ND1 ? A HIS 231 ? A HIS 231 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 ND1 ? A HIS 293 ? A HIS 293 ? 1_555 107.1 ? 
16 SG  ? A CYS 288 ? A CYS 288 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 ND1 ? A HIS 293 ? A HIS 293 ? 1_555 112.3 ? 
17 ND1 ? A HIS 231 ? A HIS 231 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 O   B M HOH .   ? A HOH 536 ? 1_555 69.5  ? 
18 SG  ? A CYS 288 ? A CYS 288 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 O   B M HOH .   ? A HOH 536 ? 1_555 94.7  ? 
19 ND1 ? A HIS 293 ? A HIS 293 ? 1_555 CU ? B CU . ? A CU 401 ? 1_555 O   B M HOH .   ? A HOH 536 ? 1_555 135.2 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 VAL 74  A . ? VAL 74  A PRO 75  A ? PRO 75  A 1 0.50 
2 GLY 208 A . ? GLY 208 A PRO 209 A ? PRO 209 A 1 6.19 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 2 ? 
AA4 ? 4 ? 
AA5 ? 5 ? 
AA6 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 MET A 63  ? GLY A 66  ? MET A 63  GLY A 66  
AA1 2 VAL A 48  ? LYS A 57  ? VAL A 48  LYS A 57  
AA1 3 THR A 86  ? ASN A 93  ? THR A 86  ASN A 93  
AA1 4 THR A 127 ? ARG A 133 ? THR A 127 ARG A 133 
AA2 1 ILE A 79  ? ASN A 82  ? ILE A 79  ASN A 82  
AA2 2 TYR A 174 ? ARG A 180 ? TYR A 174 ARG A 180 
AA2 3 GLY A 151 ? HIS A 156 ? GLY A 151 HIS A 156 
AA2 4 HIS A 102 ? VAL A 103 ? HIS A 102 VAL A 103 
AA3 1 GLY A 138 ? ARG A 139 ? GLY A 138 ARG A 139 
AA3 2 TRP A 145 ? ARG A 146 ? TRP A 145 ARG A 146 
AA4 1 THR A 199 ? PHE A 200 ? THR A 199 PHE A 200 
AA4 2 ALA A 189 ? ASN A 196 ? ALA A 189 ASN A 196 
AA4 3 ARG A 218 ? HIS A 226 ? ARG A 218 HIS A 226 
AA4 4 SER A 268 ? ILE A 274 ? SER A 268 ILE A 274 
AA5 1 PHE A 211 ? THR A 214 ? PHE A 211 THR A 214 
AA5 2 VAL A 299 ? LYS A 305 ? VAL A 299 LYS A 305 
AA5 3 GLY A 282 ? CYS A 288 ? GLY A 282 CYS A 288 
AA5 4 HIS A 231 ? MET A 235 ? HIS A 231 MET A 235 
AA5 5 ASN A 260 ? THR A 263 ? ASN A 260 THR A 263 
AA6 1 TRP A 240 ? ALA A 241 ? TRP A 240 ALA A 241 
AA6 2 VAL A 257 ? ILE A 258 ? VAL A 257 ILE A 258 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLY A 66  ? O GLY A 66  N TYR A 54  ? N TYR A 54  
AA1 2 3 N ARG A 49  ? N ARG A 49  O THR A 86  ? O THR A 86  
AA1 3 4 N LEU A 87  ? N LEU A 87  O TRP A 132 ? O TRP A 132 
AA2 1 2 N ILE A 79  ? N ILE A 79  O ILE A 178 ? O ILE A 178 
AA2 2 3 O GLY A 175 ? O GLY A 175 N TYR A 155 ? N TYR A 155 
AA2 3 4 O HIS A 156 ? O HIS A 156 N HIS A 102 ? N HIS A 102 
AA3 1 2 N GLY A 138 ? N GLY A 138 O ARG A 146 ? O ARG A 146 
AA4 1 2 O THR A 199 ? O THR A 199 N ASN A 196 ? N ASN A 196 
AA4 2 3 N LEU A 195 ? N LEU A 195 O HIS A 226 ? O HIS A 226 
AA4 3 4 N MET A 223 ? N MET A 223 O PHE A 269 ? O PHE A 269 
AA5 1 2 N ALA A 213 ? N ALA A 213 O LYS A 305 ? O LYS A 305 
AA5 2 3 O PHE A 302 ? O PHE A 302 N TRP A 284 ? N TRP A 284 
AA5 3 4 O HIS A 287 ? O HIS A 287 N HIS A 234 ? N HIS A 234 
AA5 4 5 N HIS A 231 ? N HIS A 231 O THR A 263 ? O THR A 263 
AA6 1 2 N TRP A 240 ? N TRP A 240 O ILE A 258 ? O ILE A 258 
# 
_pdbx_entry_details.entry_id                   9NJJ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 197 ? ? 57.39 -120.17 
2 1 ASN A 202 ? ? 58.60 19.41   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     649 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   M 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                
2  x+3/4,-z+3/4,y+1/4   
3  x+1/4,z+3/4,-y+3/4   
4  z+1/4,y+3/4,-x+3/4   
5  -z+3/4,y+1/4,x+3/4   
6  -y+3/4,x+1/4,z+3/4   
7  y+3/4,-x+3/4,z+1/4   
8  z,x,y                
9  y,z,x                
10 -y+1/2,-z,x+1/2      
11 z+1/2,-x+1/2,-y      
12 -y,z+1/2,-x+1/2      
13 -z+1/2,-x,y+1/2      
14 -z,x+1/2,-y+1/2      
15 y+1/2,-z+1/2,-x      
16 x+1/2,-y+1/2,-z      
17 -x,y+1/2,-z+1/2      
18 -x+1/2,-y,z+1/2      
19 y+1/4,x+3/4,-z+3/4   
20 -y+1/4,-x+1/4,-z+1/4 
21 z+3/4,-y+3/4,x+1/4   
22 -z+1/4,-y+1/4,-x+1/4 
23 -x+3/4,z+1/4,y+3/4   
24 -x+1/4,-z+1/4,-y+1/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ASP 2   ? A ASP 2   
3  1 Y 1 A ARG 3   ? A ARG 3   
4  1 Y 1 A ARG 4   ? A ARG 4   
5  1 Y 1 A GLY 5   ? A GLY 5   
6  1 Y 1 A PHE 6   ? A PHE 6   
7  1 Y 1 A ASN 7   ? A ASN 7   
8  1 Y 1 A ARG 8   ? A ARG 8   
9  1 Y 1 A ARG 9   ? A ARG 9   
10 1 Y 1 A VAL 10  ? A VAL 10  
11 1 Y 1 A LEU 11  ? A LEU 11  
12 1 Y 1 A LEU 12  ? A LEU 12  
13 1 Y 1 A GLY 13  ? A GLY 13  
14 1 Y 1 A GLY 14  ? A GLY 14  
15 1 Y 1 A ALA 15  ? A ALA 15  
16 1 Y 1 A ALA 16  ? A ALA 16  
17 1 Y 1 A ALA 17  ? A ALA 17  
18 1 Y 1 A ALA 18  ? A ALA 18  
19 1 Y 1 A THR 19  ? A THR 19  
20 1 Y 1 A SER 20  ? A SER 20  
21 1 Y 1 A LEU 21  ? A LEU 21  
22 1 Y 1 A SER 22  ? A SER 22  
23 1 Y 1 A ILE 23  ? A ILE 23  
24 1 Y 1 A ALA 24  ? A ALA 24  
25 1 Y 1 A PRO 25  ? A PRO 25  
26 1 Y 1 A GLU 26  ? A GLU 26  
27 1 Y 1 A VAL 27  ? A VAL 27  
28 1 Y 1 A ALA 28  ? A ALA 28  
29 1 Y 1 A GLY 29  ? A GLY 29  
30 1 Y 1 A ALA 30  ? A ALA 30  
31 1 Y 1 A ALA 31  ? A ALA 31  
32 1 Y 1 A PRO 32  ? A PRO 32  
33 1 Y 1 A ALA 33  ? A ALA 33  
34 1 Y 1 A ALA 34  ? A ALA 34  
35 1 Y 1 A LYS 35  ? A LYS 35  
36 1 Y 1 A GLY 36  ? A GLY 36  
37 1 Y 1 A GLU 315 ? A GLU 315 
38 1 Y 1 A PRO 316 ? A PRO 316 
39 1 Y 1 A HIS 317 ? A HIS 317 
40 1 Y 1 A GLU 318 ? A GLU 318 
41 1 Y 1 A HIS 319 ? A HIS 319 
42 1 Y 1 A GLY 320 ? A GLY 320 
43 1 Y 1 A GLY 321 ? A GLY 321 
44 1 Y 1 A ALA 322 ? A ALA 322 
45 1 Y 1 A THR 323 ? A THR 323 
46 1 Y 1 A ALA 324 ? A ALA 324 
47 1 Y 1 A LYS 325 ? A LYS 325 
48 1 Y 1 A SER 326 ? A SER 326 
49 1 Y 1 A GLY 327 ? A GLY 327 
50 1 Y 1 A GLU 328 ? A GLU 328 
51 1 Y 1 A SER 329 ? A SER 329 
52 1 Y 1 A GLY 330 ? A GLY 330 
53 1 Y 1 A GLU 331 ? A GLU 331 
54 1 Y 1 A PRO 332 ? A PRO 332 
55 1 Y 1 A THR 333 ? A THR 333 
56 1 Y 1 A GLY 334 ? A GLY 334 
57 1 Y 1 A GLY 335 ? A GLY 335 
58 1 Y 1 A ALA 336 ? A ALA 336 
59 1 Y 1 A ALA 337 ? A ALA 337 
60 1 Y 1 A ALA 338 ? A ALA 338 
61 1 Y 1 A HIS 339 ? A HIS 339 
62 1 Y 1 A GLU 340 ? A GLU 340 
63 1 Y 1 A HIS 341 ? A HIS 341 
64 1 Y 1 A GLU 342 ? A GLU 342 
65 1 Y 1 A HIS 343 ? A HIS 343 
66 1 Y 1 A LEU 344 ? A LEU 344 
67 1 Y 1 A GLU 345 ? A GLU 345 
68 1 Y 1 A HIS 346 ? A HIS 346 
69 1 Y 1 A HIS 347 ? A HIS 347 
70 1 Y 1 A HIS 348 ? A HIS 348 
71 1 Y 1 A HIS 349 ? A HIS 349 
72 1 Y 1 A HIS 350 ? A HIS 350 
73 1 Y 1 A HIS 351 ? A HIS 351 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CU  CU   CU N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
OH  O    O  N N 251 
OH  HO   H  N N 252 
PG4 O1   O  N N 253 
PG4 C1   C  N N 254 
PG4 C2   C  N N 255 
PG4 O2   O  N N 256 
PG4 C3   C  N N 257 
PG4 C4   C  N N 258 
PG4 O3   O  N N 259 
PG4 C5   C  N N 260 
PG4 C6   C  N N 261 
PG4 O4   O  N N 262 
PG4 C7   C  N N 263 
PG4 C8   C  N N 264 
PG4 O5   O  N N 265 
PG4 HO1  H  N N 266 
PG4 H11  H  N N 267 
PG4 H12  H  N N 268 
PG4 H21  H  N N 269 
PG4 H22  H  N N 270 
PG4 H31  H  N N 271 
PG4 H32  H  N N 272 
PG4 H41  H  N N 273 
PG4 H42  H  N N 274 
PG4 H51  H  N N 275 
PG4 H52  H  N N 276 
PG4 H61  H  N N 277 
PG4 H62  H  N N 278 
PG4 H71  H  N N 279 
PG4 H72  H  N N 280 
PG4 H81  H  N N 281 
PG4 H82  H  N N 282 
PG4 HO5  H  N N 283 
PHE N    N  N N 284 
PHE CA   C  N S 285 
PHE C    C  N N 286 
PHE O    O  N N 287 
PHE CB   C  N N 288 
PHE CG   C  Y N 289 
PHE CD1  C  Y N 290 
PHE CD2  C  Y N 291 
PHE CE1  C  Y N 292 
PHE CE2  C  Y N 293 
PHE CZ   C  Y N 294 
PHE OXT  O  N N 295 
PHE H    H  N N 296 
PHE H2   H  N N 297 
PHE HA   H  N N 298 
PHE HB2  H  N N 299 
PHE HB3  H  N N 300 
PHE HD1  H  N N 301 
PHE HD2  H  N N 302 
PHE HE1  H  N N 303 
PHE HE2  H  N N 304 
PHE HZ   H  N N 305 
PHE HXT  H  N N 306 
PRO N    N  N N 307 
PRO CA   C  N S 308 
PRO C    C  N N 309 
PRO O    O  N N 310 
PRO CB   C  N N 311 
PRO CG   C  N N 312 
PRO CD   C  N N 313 
PRO OXT  O  N N 314 
PRO H    H  N N 315 
PRO HA   H  N N 316 
PRO HB2  H  N N 317 
PRO HB3  H  N N 318 
PRO HG2  H  N N 319 
PRO HG3  H  N N 320 
PRO HD2  H  N N 321 
PRO HD3  H  N N 322 
PRO HXT  H  N N 323 
SER N    N  N N 324 
SER CA   C  N S 325 
SER C    C  N N 326 
SER O    O  N N 327 
SER CB   C  N N 328 
SER OG   O  N N 329 
SER OXT  O  N N 330 
SER H    H  N N 331 
SER H2   H  N N 332 
SER HA   H  N N 333 
SER HB2  H  N N 334 
SER HB3  H  N N 335 
SER HG   H  N N 336 
SER HXT  H  N N 337 
THR N    N  N N 338 
THR CA   C  N S 339 
THR C    C  N N 340 
THR O    O  N N 341 
THR CB   C  N R 342 
THR OG1  O  N N 343 
THR CG2  C  N N 344 
THR OXT  O  N N 345 
THR H    H  N N 346 
THR H2   H  N N 347 
THR HA   H  N N 348 
THR HB   H  N N 349 
THR HG1  H  N N 350 
THR HG21 H  N N 351 
THR HG22 H  N N 352 
THR HG23 H  N N 353 
THR HXT  H  N N 354 
TRP N    N  N N 355 
TRP CA   C  N S 356 
TRP C    C  N N 357 
TRP O    O  N N 358 
TRP CB   C  N N 359 
TRP CG   C  Y N 360 
TRP CD1  C  Y N 361 
TRP CD2  C  Y N 362 
TRP NE1  N  Y N 363 
TRP CE2  C  Y N 364 
TRP CE3  C  Y N 365 
TRP CZ2  C  Y N 366 
TRP CZ3  C  Y N 367 
TRP CH2  C  Y N 368 
TRP OXT  O  N N 369 
TRP H    H  N N 370 
TRP H2   H  N N 371 
TRP HA   H  N N 372 
TRP HB2  H  N N 373 
TRP HB3  H  N N 374 
TRP HD1  H  N N 375 
TRP HE1  H  N N 376 
TRP HE3  H  N N 377 
TRP HZ2  H  N N 378 
TRP HZ3  H  N N 379 
TRP HH2  H  N N 380 
TRP HXT  H  N N 381 
TYR N    N  N N 382 
TYR CA   C  N S 383 
TYR C    C  N N 384 
TYR O    O  N N 385 
TYR CB   C  N N 386 
TYR CG   C  Y N 387 
TYR CD1  C  Y N 388 
TYR CD2  C  Y N 389 
TYR CE1  C  Y N 390 
TYR CE2  C  Y N 391 
TYR CZ   C  Y N 392 
TYR OH   O  N N 393 
TYR OXT  O  N N 394 
TYR H    H  N N 395 
TYR H2   H  N N 396 
TYR HA   H  N N 397 
TYR HB2  H  N N 398 
TYR HB3  H  N N 399 
TYR HD1  H  N N 400 
TYR HD2  H  N N 401 
TYR HE1  H  N N 402 
TYR HE2  H  N N 403 
TYR HH   H  N N 404 
TYR HXT  H  N N 405 
VAL N    N  N N 406 
VAL CA   C  N S 407 
VAL C    C  N N 408 
VAL O    O  N N 409 
VAL CB   C  N N 410 
VAL CG1  C  N N 411 
VAL CG2  C  N N 412 
VAL OXT  O  N N 413 
VAL H    H  N N 414 
VAL H2   H  N N 415 
VAL HA   H  N N 416 
VAL HB   H  N N 417 
VAL HG11 H  N N 418 
VAL HG12 H  N N 419 
VAL HG13 H  N N 420 
VAL HG21 H  N N 421 
VAL HG22 H  N N 422 
VAL HG23 H  N N 423 
VAL HXT  H  N N 424 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
OH  O   HO   sing N N 237 
PG4 O1  C1   sing N N 238 
PG4 O1  HO1  sing N N 239 
PG4 C1  C2   sing N N 240 
PG4 C1  H11  sing N N 241 
PG4 C1  H12  sing N N 242 
PG4 C2  O2   sing N N 243 
PG4 C2  H21  sing N N 244 
PG4 C2  H22  sing N N 245 
PG4 O2  C3   sing N N 246 
PG4 C3  C4   sing N N 247 
PG4 C3  H31  sing N N 248 
PG4 C3  H32  sing N N 249 
PG4 C4  O3   sing N N 250 
PG4 C4  H41  sing N N 251 
PG4 C4  H42  sing N N 252 
PG4 O3  C5   sing N N 253 
PG4 C5  C6   sing N N 254 
PG4 C5  H51  sing N N 255 
PG4 C5  H52  sing N N 256 
PG4 C6  O4   sing N N 257 
PG4 C6  H61  sing N N 258 
PG4 C6  H62  sing N N 259 
PG4 O4  C7   sing N N 260 
PG4 C7  C8   sing N N 261 
PG4 C7  H71  sing N N 262 
PG4 C7  H72  sing N N 263 
PG4 C8  O5   sing N N 264 
PG4 C8  H81  sing N N 265 
PG4 C8  H82  sing N N 266 
PG4 O5  HO5  sing N N 267 
PHE N   CA   sing N N 268 
PHE N   H    sing N N 269 
PHE N   H2   sing N N 270 
PHE CA  C    sing N N 271 
PHE CA  CB   sing N N 272 
PHE CA  HA   sing N N 273 
PHE C   O    doub N N 274 
PHE C   OXT  sing N N 275 
PHE CB  CG   sing N N 276 
PHE CB  HB2  sing N N 277 
PHE CB  HB3  sing N N 278 
PHE CG  CD1  doub Y N 279 
PHE CG  CD2  sing Y N 280 
PHE CD1 CE1  sing Y N 281 
PHE CD1 HD1  sing N N 282 
PHE CD2 CE2  doub Y N 283 
PHE CD2 HD2  sing N N 284 
PHE CE1 CZ   doub Y N 285 
PHE CE1 HE1  sing N N 286 
PHE CE2 CZ   sing Y N 287 
PHE CE2 HE2  sing N N 288 
PHE CZ  HZ   sing N N 289 
PHE OXT HXT  sing N N 290 
PRO N   CA   sing N N 291 
PRO N   CD   sing N N 292 
PRO N   H    sing N N 293 
PRO CA  C    sing N N 294 
PRO CA  CB   sing N N 295 
PRO CA  HA   sing N N 296 
PRO C   O    doub N N 297 
PRO C   OXT  sing N N 298 
PRO CB  CG   sing N N 299 
PRO CB  HB2  sing N N 300 
PRO CB  HB3  sing N N 301 
PRO CG  CD   sing N N 302 
PRO CG  HG2  sing N N 303 
PRO CG  HG3  sing N N 304 
PRO CD  HD2  sing N N 305 
PRO CD  HD3  sing N N 306 
PRO OXT HXT  sing N N 307 
SER N   CA   sing N N 308 
SER N   H    sing N N 309 
SER N   H2   sing N N 310 
SER CA  C    sing N N 311 
SER CA  CB   sing N N 312 
SER CA  HA   sing N N 313 
SER C   O    doub N N 314 
SER C   OXT  sing N N 315 
SER CB  OG   sing N N 316 
SER CB  HB2  sing N N 317 
SER CB  HB3  sing N N 318 
SER OG  HG   sing N N 319 
SER OXT HXT  sing N N 320 
THR N   CA   sing N N 321 
THR N   H    sing N N 322 
THR N   H2   sing N N 323 
THR CA  C    sing N N 324 
THR CA  CB   sing N N 325 
THR CA  HA   sing N N 326 
THR C   O    doub N N 327 
THR C   OXT  sing N N 328 
THR CB  OG1  sing N N 329 
THR CB  CG2  sing N N 330 
THR CB  HB   sing N N 331 
THR OG1 HG1  sing N N 332 
THR CG2 HG21 sing N N 333 
THR CG2 HG22 sing N N 334 
THR CG2 HG23 sing N N 335 
THR OXT HXT  sing N N 336 
TRP N   CA   sing N N 337 
TRP N   H    sing N N 338 
TRP N   H2   sing N N 339 
TRP CA  C    sing N N 340 
TRP CA  CB   sing N N 341 
TRP CA  HA   sing N N 342 
TRP C   O    doub N N 343 
TRP C   OXT  sing N N 344 
TRP CB  CG   sing N N 345 
TRP CB  HB2  sing N N 346 
TRP CB  HB3  sing N N 347 
TRP CG  CD1  doub Y N 348 
TRP CG  CD2  sing Y N 349 
TRP CD1 NE1  sing Y N 350 
TRP CD1 HD1  sing N N 351 
TRP CD2 CE2  doub Y N 352 
TRP CD2 CE3  sing Y N 353 
TRP NE1 CE2  sing Y N 354 
TRP NE1 HE1  sing N N 355 
TRP CE2 CZ2  sing Y N 356 
TRP CE3 CZ3  doub Y N 357 
TRP CE3 HE3  sing N N 358 
TRP CZ2 CH2  doub Y N 359 
TRP CZ2 HZ2  sing N N 360 
TRP CZ3 CH2  sing Y N 361 
TRP CZ3 HZ3  sing N N 362 
TRP CH2 HH2  sing N N 363 
TRP OXT HXT  sing N N 364 
TYR N   CA   sing N N 365 
TYR N   H    sing N N 366 
TYR N   H2   sing N N 367 
TYR CA  C    sing N N 368 
TYR CA  CB   sing N N 369 
TYR CA  HA   sing N N 370 
TYR C   O    doub N N 371 
TYR C   OXT  sing N N 372 
TYR CB  CG   sing N N 373 
TYR CB  HB2  sing N N 374 
TYR CB  HB3  sing N N 375 
TYR CG  CD1  doub Y N 376 
TYR CG  CD2  sing Y N 377 
TYR CD1 CE1  sing Y N 378 
TYR CD1 HD1  sing N N 379 
TYR CD2 CE2  doub Y N 380 
TYR CD2 HD2  sing N N 381 
TYR CE1 CZ   doub Y N 382 
TYR CE1 HE1  sing N N 383 
TYR CE2 CZ   sing Y N 384 
TYR CE2 HE2  sing N N 385 
TYR CZ  OH   sing N N 386 
TYR OH  HH   sing N N 387 
TYR OXT HXT  sing N N 388 
VAL N   CA   sing N N 389 
VAL N   H    sing N N 390 
VAL N   H2   sing N N 391 
VAL CA  C    sing N N 392 
VAL CA  CB   sing N N 393 
VAL CA  HA   sing N N 394 
VAL C   O    doub N N 395 
VAL C   OXT  sing N N 396 
VAL CB  CG1  sing N N 397 
VAL CB  CG2  sing N N 398 
VAL CB  HB   sing N N 399 
VAL CG1 HG11 sing N N 400 
VAL CG1 HG12 sing N N 401 
VAL CG1 HG13 sing N N 402 
VAL CG2 HG21 sing N N 403 
VAL CG2 HG22 sing N N 404 
VAL CG2 HG23 sing N N 405 
VAL OXT HXT  sing N N 406 
# 
_pdbx_audit_support.funding_organization   'National Science Foundation (NSF, United States)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8U8P 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 3 2' 
_space_group.name_Hall        'P 4acd 2ab 3' 
_space_group.IT_number        212 
_space_group.crystal_system   cubic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9NJJ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005623 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005623 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005623 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CU ? ? 23.42449 5.47274 ? ? 2.18335  24.96234 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 7.96527  ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ILE A 1 37  ? 12.96350  -13.32125 1.24135   1.000 68.01599  ? 37  ILE A N   1 
ATOM   2    C  CA  . ILE A 1 37  ? 12.65310  -14.53129 0.49036   1.000 88.40338  ? 37  ILE A CA  1 
ATOM   3    C  C   . ILE A 1 37  ? 13.92907  -15.31341 0.19044   1.000 87.63574  ? 37  ILE A C   1 
ATOM   4    O  O   . ILE A 1 37  ? 14.81667  -14.82600 -0.51029  1.000 93.64672  ? 37  ILE A O   1 
ATOM   5    C  CB  . ILE A 1 37  ? 11.89468  -14.20075 -0.81267  1.000 82.78064  ? 37  ILE A CB  1 
ATOM   6    C  CG1 . ILE A 1 37  ? 10.47074  -13.73345 -0.49861  1.000 85.70894  ? 37  ILE A CG1 1 
ATOM   7    C  CG2 . ILE A 1 37  ? 11.87454  -15.40844 -1.74359  1.000 72.12343  ? 37  ILE A CG2 1 
ATOM   8    C  CD1 . ILE A 1 37  ? 9.52689   -13.78326 -1.68542  1.000 75.29136  ? 37  ILE A CD1 1 
ATOM   9    N  N   . THR A 1 38  ? 14.01815  -16.53002 0.72972   1.000 85.57777  ? 38  THR A N   1 
ATOM   10   C  CA  . THR A 1 38  ? 15.14428  -17.41964 0.48008   1.000 76.88592  ? 38  THR A CA  1 
ATOM   11   C  C   . THR A 1 38  ? 14.82438  -18.47839 -0.57021  1.000 84.67521  ? 38  THR A C   1 
ATOM   12   O  O   . THR A 1 38  ? 15.53767  -19.48307 -0.66969  1.000 75.23981  ? 38  THR A O   1 
ATOM   13   C  CB  . THR A 1 38  ? 15.59986  -18.08481 1.78059   1.000 76.23240  ? 38  THR A CB  1 
ATOM   14   O  OG1 . THR A 1 38  ? 14.86118  -19.29554 1.98865   1.000 75.88453  ? 38  THR A OG1 1 
ATOM   15   C  CG2 . THR A 1 38  ? 15.38647  -17.14967 2.96261   1.000 78.58685  ? 38  THR A CG2 1 
ATOM   16   N  N   . ALA A 1 39  ? 13.76442  -18.27806 -1.34502  1.000 75.81349  ? 39  ALA A N   1 
ATOM   17   C  CA  . ALA A 1 39  ? 13.45669  -19.14000 -2.47332  1.000 70.38513  ? 39  ALA A CA  1 
ATOM   18   C  C   . ALA A 1 39  ? 14.09574  -18.58464 -3.74142  1.000 64.73979  ? 39  ALA A C   1 
ATOM   19   O  O   . ALA A 1 39  ? 14.44031  -17.40331 -3.82649  1.000 71.80041  ? 39  ALA A O   1 
ATOM   20   C  CB  . ALA A 1 39  ? 11.94471  -19.27421 -2.65755  1.000 58.16377  ? 39  ALA A CB  1 
ATOM   21   N  N   . ARG A 1 40  ? 14.25996  -19.45896 -4.73094  1.000 57.82873  ? 40  ARG A N   1 
ATOM   22   C  CA  . ARG A 1 40  ? 14.83285  -19.04194 -6.00339  1.000 63.76331  ? 40  ARG A CA  1 
ATOM   23   C  C   . ARG A 1 40  ? 13.89611  -18.06381 -6.70028  1.000 62.18100  ? 40  ARG A C   1 
ATOM   24   O  O   . ARG A 1 40  ? 12.69168  -18.31242 -6.81197  1.000 56.44183  ? 40  ARG A O   1 
ATOM   25   C  CB  . ARG A 1 40  ? 15.09346  -20.25429 -6.89438  1.000 65.43167  ? 40  ARG A CB  1 
ATOM   26   C  CG  . ARG A 1 40  ? 16.35780  -21.01844 -6.54515  1.000 73.11715  ? 40  ARG A CG  1 
ATOM   27   C  CD  . ARG A 1 40  ? 16.31536  -22.43509 -7.09552  1.000 78.15189  ? 40  ARG A CD  1 
ATOM   28   N  NE  . ARG A 1 40  ? 15.71079  -22.48756 -8.42144  1.000 76.56733  ? 40  ARG A NE  1 
ATOM   29   C  CZ  . ARG A 1 40  ? 14.64677  -23.21574 -8.73187  1.000 84.51421  ? 40  ARG A CZ  1 
ATOM   30   N  NH1 . ARG A 1 40  ? 14.03857  -23.97101 -7.83081  1.000 72.17282  ? 40  ARG A NH1 1 
ATOM   31   N  NH2 . ARG A 1 40  ? 14.18113  -23.18554 -9.97761  1.000 75.56818  ? 40  ARG A NH2 1 
ATOM   32   N  N   . THR A 1 41  ? 14.44814  -16.94681 -7.16321  1.000 55.73753  ? 41  THR A N   1 
ATOM   33   C  CA  . THR A 1 41  ? 13.66583  -15.90721 -7.80937  1.000 51.60058  ? 41  THR A CA  1 
ATOM   34   C  C   . THR A 1 41  ? 14.15478  -15.68483 -9.23449  1.000 52.15351  ? 41  THR A C   1 
ATOM   35   O  O   . THR A 1 41  ? 15.31059  -15.95714 -9.57097  1.000 56.02877  ? 41  THR A O   1 
ATOM   36   C  CB  . THR A 1 41  ? 13.72460  -14.59121 -7.02312  1.000 44.48835  ? 41  THR A CB  1 
ATOM   37   O  OG1 . THR A 1 41  ? 15.08773  -14.27085 -6.72218  1.000 64.97854  ? 41  THR A OG1 1 
ATOM   38   C  CG2 . THR A 1 41  ? 12.93936  -14.71405 -5.72772  1.000 46.07341  ? 41  THR A CG2 1 
ATOM   39   N  N   . ALA A 1 42  ? 13.25061  -15.18660 -10.07117 1.000 47.16506  ? 42  ALA A N   1 
ATOM   40   C  CA  . ALA A 1 42  ? 13.58645  -14.94044 -11.46335 1.000 45.91607  ? 42  ALA A CA  1 
ATOM   41   C  C   . ALA A 1 42  ? 14.53799  -13.75162 -11.57265 1.000 48.00608  ? 42  ALA A C   1 
ATOM   42   O  O   . ALA A 1 42  ? 14.37067  -12.75224 -10.86584 1.000 50.18890  ? 42  ALA A O   1 
ATOM   43   C  CB  . ALA A 1 42  ? 12.32425  -14.67699 -12.28323 1.000 42.16393  ? 42  ALA A CB  1 
ATOM   44   N  N   . PRO A 1 43  ? 15.54165  -13.82787 -12.43834 1.000 47.08800  ? 43  PRO A N   1 
ATOM   45   C  CA  . PRO A 1 43  ? 16.46545  -12.70601 -12.61207 1.000 48.23071  ? 43  PRO A CA  1 
ATOM   46   C  C   . PRO A 1 43  ? 15.89018  -11.65565 -13.55347 1.000 53.91053  ? 43  PRO A C   1 
ATOM   47   O  O   . PRO A 1 43  ? 14.86111  -11.85040 -14.20162 1.000 63.82459  ? 43  PRO A O   1 
ATOM   48   C  CB  . PRO A 1 43  ? 17.69829  -13.37667 -13.21859 1.000 47.97993  ? 43  PRO A CB  1 
ATOM   49   C  CG  . PRO A 1 43  ? 17.10889  -14.46115 -14.06306 1.000 47.58616  ? 43  PRO A CG  1 
ATOM   50   C  CD  . PRO A 1 43  ? 15.91924  -14.98003 -13.27690 1.000 46.81407  ? 43  PRO A CD  1 
ATOM   51   N  N   . ALA A 1 44  ? 16.58254  -10.52218 -13.61517 1.000 53.92685  ? 44  ALA A N   1 
ATOM   52   C  CA  . ALA A 1 44  ? 16.21371  -9.48015  -14.56079 1.000 46.88797  ? 44  ALA A CA  1 
ATOM   53   C  C   . ALA A 1 44  ? 16.45481  -9.95958  -15.98673 1.000 54.06895  ? 44  ALA A C   1 
ATOM   54   O  O   . ALA A 1 44  ? 17.42678  -10.66657 -16.26653 1.000 60.19911  ? 44  ALA A O   1 
ATOM   55   C  CB  . ALA A 1 44  ? 17.00925  -8.20495  -14.28804 1.000 53.52192  ? 44  ALA A CB  1 
ATOM   56   N  N   . GLY A 1 45  ? 15.55399  -9.57867  -16.89257 1.000 50.30789  ? 45  GLY A N   1 
ATOM   57   C  CA  . GLY A 1 45  ? 15.65221  -9.98185  -18.27769 1.000 49.86577  ? 45  GLY A CA  1 
ATOM   58   C  C   . GLY A 1 45  ? 16.38753  -8.96450  -19.13119 1.000 56.15372  ? 45  GLY A C   1 
ATOM   59   O  O   . GLY A 1 45  ? 16.88258  -7.94273  -18.65769 1.000 57.05852  ? 45  GLY A O   1 
ATOM   60   N  N   . GLY A 1 46  ? 16.45198  -9.26590  -20.42553 1.000 52.85096  ? 46  GLY A N   1 
ATOM   61   C  CA  . GLY A 1 46  ? 17.12464  -8.39963  -21.37192 1.000 45.40073  ? 46  GLY A CA  1 
ATOM   62   C  C   . GLY A 1 46  ? 17.99178  -9.15388  -22.35760 1.000 46.97680  ? 46  GLY A C   1 
ATOM   63   O  O   . GLY A 1 46  ? 18.76510  -8.54729  -23.10442 1.000 69.68544  ? 46  GLY A O   1 
ATOM   64   N  N   . GLU A 1 47  ? 17.87291  -10.47738 -22.36950 1.000 54.69941  ? 47  GLU A N   1 
ATOM   65   C  CA  . GLU A 1 47  ? 18.65004  -11.31400 -23.27008 1.000 55.55124  ? 47  GLU A CA  1 
ATOM   66   C  C   . GLU A 1 47  ? 17.89621  -11.53804 -24.57409 1.000 56.02324  ? 47  GLU A C   1 
ATOM   67   O  O   . GLU A 1 47  ? 16.66478  -11.60203 -24.60066 1.000 57.75041  ? 47  GLU A O   1 
ATOM   68   C  CB  . GLU A 1 47  ? 18.96730  -12.66246 -22.62093 1.000 54.82203  ? 47  GLU A CB  1 
ATOM   69   C  CG  . GLU A 1 47  ? 19.85659  -12.57280 -21.39262 1.000 80.68185  ? 47  GLU A CG  1 
ATOM   70   C  CD  . GLU A 1 47  ? 21.31018  -12.32947 -21.74436 1.000 94.38502  ? 47  GLU A CD  1 
ATOM   71   O  OE1 . GLU A 1 47  ? 21.92242  -13.20748 -22.38813 1.000 96.56393  ? 47  GLU A OE1 1 
ATOM   72   O  OE2 . GLU A 1 47  ? 21.84127  -11.26067 -21.37500 1.000 94.33834  ? 47  GLU A OE2 1 
ATOM   73   N  N   . VAL A 1 48  ? 18.64966  -11.65919 -25.66053 1.000 54.18593  ? 48  VAL A N   1 
ATOM   74   C  CA  . VAL A 1 48  ? 18.09296  -11.97571 -26.96961 1.000 48.89902  ? 48  VAL A CA  1 
ATOM   75   C  C   . VAL A 1 48  ? 18.22530  -13.48016 -27.16568 1.000 48.20220  ? 48  VAL A C   1 
ATOM   76   O  O   . VAL A 1 48  ? 19.33111  -13.99760 -27.35545 1.000 60.73782  ? 48  VAL A O   1 
ATOM   77   C  CB  . VAL A 1 48  ? 18.79437  -11.19743 -28.08977 1.000 45.19815  ? 48  VAL A CB  1 
ATOM   78   C  CG1 . VAL A 1 48  ? 18.36992  -11.73066 -29.45022 1.000 48.82414  ? 48  VAL A CG1 1 
ATOM   79   C  CG2 . VAL A 1 48  ? 18.48747  -9.71346  -27.97391 1.000 42.69445  ? 48  VAL A CG2 1 
ATOM   80   N  N   . ARG A 1 49  ? 17.10231  -14.18757 -27.11022 1.000 50.57116  ? 49  ARG A N   1 
ATOM   81   C  CA  . ARG A 1 49  ? 17.08698  -15.63648 -27.23099 1.000 47.61839  ? 49  ARG A CA  1 
ATOM   82   C  C   . ARG A 1 49  ? 16.72761  -16.05317 -28.65089 1.000 50.10128  ? 49  ARG A C   1 
ATOM   83   O  O   . ARG A 1 49  ? 16.01954  -15.34305 -29.36898 1.000 52.91955  ? 49  ARG A O   1 
ATOM   84   C  CB  . ARG A 1 49  ? 16.09734  -16.25758 -26.24398 1.000 48.62632  ? 49  ARG A CB  1 
ATOM   85   C  CG  . ARG A 1 49  ? 16.32138  -15.84811 -24.79949 1.000 51.07794  ? 49  ARG A CG  1 
ATOM   86   C  CD  . ARG A 1 49  ? 15.07459  -16.08610 -23.96237 1.000 57.48477  ? 49  ARG A CD  1 
ATOM   87   N  NE  . ARG A 1 49  ? 15.29572  -15.79027 -22.55190 1.000 61.35527  ? 49  ARG A NE  1 
ATOM   88   C  CZ  . ARG A 1 49  ? 15.98052  -16.56318 -21.72076 1.000 56.87379  ? 49  ARG A CZ  1 
ATOM   89   N  NH1 . ARG A 1 49  ? 16.51050  -17.70756 -22.11949 1.000 66.71260  ? 49  ARG A NH1 1 
ATOM   90   N  NH2 . ARG A 1 49  ? 16.13461  -16.17941 -20.45665 1.000 57.94527  ? 49  ARG A NH2 1 
ATOM   91   N  N   . HIS A 1 50  ? 17.22705  -17.22046 -29.04702 1.000 54.94367  ? 50  HIS A N   1 
ATOM   92   C  CA  . HIS A 1 50  ? 16.96932  -17.78623 -30.36198 1.000 49.61372  ? 50  HIS A CA  1 
ATOM   93   C  C   . HIS A 1 50  ? 16.40289  -19.18700 -30.20152 1.000 50.16874  ? 50  HIS A C   1 
ATOM   94   O  O   . HIS A 1 50  ? 16.88929  -19.97374 -29.38443 1.000 58.25411  ? 50  HIS A O   1 
ATOM   95   C  CB  . HIS A 1 50  ? 18.24241  -17.82431 -31.21234 1.000 48.66494  ? 50  HIS A CB  1 
ATOM   96   C  CG  . HIS A 1 50  ? 18.69143  -16.47610 -31.68178 1.000 63.23280  ? 50  HIS A CG  1 
ATOM   97   N  ND1 . HIS A 1 50  ? 19.51533  -15.66310 -30.93307 1.000 66.63577  ? 50  HIS A ND1 1 
ATOM   98   C  CD2 . HIS A 1 50  ? 18.43025  -15.79751 -32.82401 1.000 62.96658  ? 50  HIS A CD2 1 
ATOM   99   C  CE1 . HIS A 1 50  ? 19.74178  -14.54158 -31.59372 1.000 61.73358  ? 50  HIS A CE1 1 
ATOM   100  N  NE2 . HIS A 1 50  ? 19.09561  -14.59827 -32.74440 1.000 63.07486  ? 50  HIS A NE2 1 
ATOM   101  N  N   . LEU A 1 51  ? 15.37154  -19.49087 -30.98323 1.000 50.45160  ? 51  LEU A N   1 
ATOM   102  C  CA  . LEU A 1 51  ? 14.67319  -20.76205 -30.88744 1.000 46.43718  ? 51  LEU A CA  1 
ATOM   103  C  C   . LEU A 1 51  ? 14.37829  -21.28512 -32.28283 1.000 47.71513  ? 51  LEU A C   1 
ATOM   104  O  O   . LEU A 1 51  ? 14.07381  -20.51021 -33.19348 1.000 47.37327  ? 51  LEU A O   1 
ATOM   105  C  CB  . LEU A 1 51  ? 13.36129  -20.62076 -30.10209 1.000 51.51124  ? 51  LEU A CB  1 
ATOM   106  C  CG  . LEU A 1 51  ? 13.35246  -21.06226 -28.63904 1.000 61.27501  ? 51  LEU A CG  1 
ATOM   107  C  CD1 . LEU A 1 51  ? 11.94092  -20.99611 -28.07827 1.000 65.07155  ? 51  LEU A CD1 1 
ATOM   108  C  CD2 . LEU A 1 51  ? 13.91895  -22.46377 -28.50155 1.000 73.26056  ? 51  LEU A CD2 1 
ATOM   109  N  N   . LYS A 1 52  ? 14.47677  -22.59977 -32.44365 1.000 46.00610  ? 52  LYS A N   1 
ATOM   110  C  CA  . LYS A 1 52  ? 14.02860  -23.28374 -33.64558 1.000 45.59957  ? 52  LYS A CA  1 
ATOM   111  C  C   . LYS A 1 52  ? 12.77810  -24.08164 -33.30759 1.000 47.73493  ? 52  LYS A C   1 
ATOM   112  O  O   . LYS A 1 52  ? 12.71875  -24.74793 -32.26946 1.000 50.08593  ? 52  LYS A O   1 
ATOM   113  C  CB  . LYS A 1 52  ? 15.11788  -24.20248 -34.20345 1.000 45.48763  ? 52  LYS A CB  1 
ATOM   114  C  CG  . LYS A 1 52  ? 14.67828  -25.01976 -35.40344 1.000 55.66506  ? 52  LYS A CG  1 
ATOM   115  C  CD  . LYS A 1 52  ? 14.98979  -24.29620 -36.70131 1.000 63.44414  ? 52  LYS A CD  1 
ATOM   116  C  CE  . LYS A 1 52  ? 13.83798  -24.40900 -37.68417 1.000 59.79656  ? 52  LYS A CE  1 
ATOM   117  N  NZ  . LYS A 1 52  ? 14.29184  -24.25577 -39.09413 1.000 78.60416  ? 52  LYS A NZ  1 
ATOM   118  N  N   . MET A 1 53  ? 11.77800  -24.00889 -34.18069 1.000 52.47520  ? 53  MET A N   1 
ATOM   119  C  CA  . MET A 1 53  ? 10.46086  -24.52570 -33.84794 1.000 44.98138  ? 53  MET A CA  1 
ATOM   120  C  C   . MET A 1 53  ? 9.83255   -25.11093 -35.10332 1.000 46.45986  ? 53  MET A C   1 
ATOM   121  O  O   . MET A 1 53  ? 9.94852   -24.53338 -36.18691 1.000 50.21336  ? 53  MET A O   1 
ATOM   122  C  CB  . MET A 1 53  ? 9.59465   -23.40868 -33.25857 1.000 50.36757  ? 53  MET A CB  1 
ATOM   123  C  CG  . MET A 1 53  ? 9.60066   -23.36525 -31.73667 1.000 66.14308  ? 53  MET A CG  1 
ATOM   124  S  SD  . MET A 1 53  ? 8.01832   -22.87142 -31.03512 1.000 67.76040  ? 53  MET A SD  1 
ATOM   125  C  CE  . MET A 1 53  ? 6.99062   -24.21751 -31.59091 1.000 65.02793  ? 53  MET A CE  1 
ATOM   126  N  N   . TYR A 1 54  ? 9.18054   -26.26136 -34.95662 1.000 44.21045  ? 54  TYR A N   1 
ATOM   127  C  CA  . TYR A 1 54  ? 8.58582   -26.96353 -36.08301 1.000 42.71689  ? 54  TYR A CA  1 
ATOM   128  C  C   . TYR A 1 54  ? 7.10644   -27.21655 -35.83248 1.000 41.71576  ? 54  TYR A C   1 
ATOM   129  O  O   . TYR A 1 54  ? 6.67374   -27.39814 -34.69120 1.000 47.62235  ? 54  TYR A O   1 
ATOM   130  C  CB  . TYR A 1 54  ? 9.28334   -28.30933 -36.35084 1.000 43.42517  ? 54  TYR A CB  1 
ATOM   131  C  CG  . TYR A 1 54  ? 10.76691  -28.21341 -36.61966 1.000 46.67031  ? 54  TYR A CG  1 
ATOM   132  C  CD1 . TYR A 1 54  ? 11.67896  -28.16388 -35.57411 1.000 41.72635  ? 54  TYR A CD1 1 
ATOM   133  C  CD2 . TYR A 1 54  ? 11.25666  -28.17813 -37.91923 1.000 50.05904  ? 54  TYR A CD2 1 
ATOM   134  C  CE1 . TYR A 1 54  ? 13.03652  -28.07767 -35.81393 1.000 54.93240  ? 54  TYR A CE1 1 
ATOM   135  C  CE2 . TYR A 1 54  ? 12.61411  -28.09101 -38.16909 1.000 49.51437  ? 54  TYR A CE2 1 
ATOM   136  C  CZ  . TYR A 1 54  ? 13.49884  -28.04035 -37.11350 1.000 54.42875  ? 54  TYR A CZ  1 
ATOM   137  O  OH  . TYR A 1 54  ? 14.84965  -27.95469 -37.36185 1.000 64.48275  ? 54  TYR A OH  1 
ATOM   138  N  N   . ALA A 1 55  ? 6.33634   -27.22731 -36.91674 1.000 45.53094  ? 55  ALA A N   1 
ATOM   139  C  CA  . ALA A 1 55  ? 4.95739   -27.69824 -36.91283 1.000 38.02386  ? 55  ALA A CA  1 
ATOM   140  C  C   . ALA A 1 55  ? 4.93173   -29.03873 -37.63103 1.000 42.51611  ? 55  ALA A C   1 
ATOM   141  O  O   . ALA A 1 55  ? 5.37145   -29.13653 -38.78174 1.000 47.27174  ? 55  ALA A O   1 
ATOM   142  C  CB  . ALA A 1 55  ? 4.02038   -26.69914 -37.59008 1.000 38.77146  ? 55  ALA A CB  1 
ATOM   143  N  N   . GLU A 1 56  ? 4.42803   -30.06535 -36.95396 1.000 43.27514  ? 56  GLU A N   1 
ATOM   144  C  CA  . GLU A 1 56  ? 4.54791   -31.43589 -37.42401 1.000 38.59879  ? 56  GLU A CA  1 
ATOM   145  C  C   . GLU A 1 56  ? 3.19301   -32.12387 -37.40412 1.000 41.27133  ? 56  GLU A C   1 
ATOM   146  O  O   . GLU A 1 56  ? 2.44181   -32.00824 -36.43182 1.000 45.96629  ? 56  GLU A O   1 
ATOM   147  C  CB  . GLU A 1 56  ? 5.53379   -32.22590 -36.55362 1.000 48.17053  ? 56  GLU A CB  1 
ATOM   148  C  CG  . GLU A 1 56  ? 6.63227   -32.93331 -37.32334 1.000 63.49695  ? 56  GLU A CG  1 
ATOM   149  C  CD  . GLU A 1 56  ? 7.63682   -33.61292 -36.40858 1.000 74.19362  ? 56  GLU A CD  1 
ATOM   150  O  OE1 . GLU A 1 56  ? 7.31291   -34.68517 -35.85219 1.000 80.11393  ? 56  GLU A OE1 1 
ATOM   151  O  OE2 . GLU A 1 56  ? 8.74981   -33.07133 -36.24237 1.000 69.46337  ? 56  GLU A OE2 1 
ATOM   152  N  N   . LYS A 1 57  ? 2.88831   -32.84346 -38.47911 1.000 39.07690  ? 57  LYS A N   1 
ATOM   153  C  CA  . LYS A 1 57  ? 1.75428   -33.75488 -38.47798 1.000 40.64226  ? 57  LYS A CA  1 
ATOM   154  C  C   . LYS A 1 57  ? 2.15492   -35.05552 -37.79714 1.000 46.48590  ? 57  LYS A C   1 
ATOM   155  O  O   . LYS A 1 57  ? 3.14944   -35.68270 -38.17412 1.000 50.21578  ? 57  LYS A O   1 
ATOM   156  C  CB  . LYS A 1 57  ? 1.27604   -34.03229 -39.90148 1.000 52.05663  ? 57  LYS A CB  1 
ATOM   157  C  CG  . LYS A 1 57  ? -0.12205  -33.52447 -40.19306 1.000 66.35239  ? 57  LYS A CG  1 
ATOM   158  C  CD  . LYS A 1 57  ? -0.77295  -34.33122 -41.30406 1.000 77.75384  ? 57  LYS A CD  1 
ATOM   159  C  CE  . LYS A 1 57  ? -1.24330  -33.43007 -42.43054 1.000 69.64779  ? 57  LYS A CE  1 
ATOM   160  N  NZ  . LYS A 1 57  ? -2.15104  -34.14136 -43.37161 1.000 82.58703  ? 57  LYS A NZ  1 
ATOM   161  N  N   . LEU A 1 58  ? 1.38801   -35.45638 -36.79245 1.000 49.77998  ? 58  LEU A N   1 
ATOM   162  C  CA  . LEU A 1 58  ? 1.69514   -36.67049 -36.05654 1.000 45.97592  ? 58  LEU A CA  1 
ATOM   163  C  C   . LEU A 1 58  ? 1.00832   -37.87237 -36.69680 1.000 49.30326  ? 58  LEU A C   1 
ATOM   164  O  O   . LEU A 1 58  ? 0.08285   -37.73835 -37.50067 1.000 60.05250  ? 58  LEU A O   1 
ATOM   165  C  CB  . LEU A 1 58  ? 1.28121   -36.53076 -34.59155 1.000 50.28387  ? 58  LEU A CB  1 
ATOM   166  C  CG  . LEU A 1 58  ? 1.87751   -35.31416 -33.87784 1.000 49.18266  ? 58  LEU A CG  1 
ATOM   167  C  CD1 . LEU A 1 58  ? 1.45880   -35.26967 -32.41507 1.000 52.96763  ? 58  LEU A CD1 1 
ATOM   168  C  CD2 . LEU A 1 58  ? 3.39144   -35.30883 -34.00747 1.000 48.47923  ? 58  LEU A CD2 1 
ATOM   169  N  N   . ALA A 1 59  ? 1.48732   -39.06264 -36.32642 1.000 63.16044  ? 59  ALA A N   1 
ATOM   170  C  CA  . ALA A 1 59  ? 1.00092   -40.29232 -36.94220 1.000 52.17873  ? 59  ALA A CA  1 
ATOM   171  C  C   . ALA A 1 59  ? -0.48880  -40.49779 -36.70427 1.000 54.85886  ? 59  ALA A C   1 
ATOM   172  O  O   . ALA A 1 59  ? -1.19042  -41.01630 -37.57994 1.000 60.66569  ? 59  ALA A O   1 
ATOM   173  C  CB  . ALA A 1 59  ? 1.79067   -41.48779 -36.40903 1.000 56.40552  ? 59  ALA A CB  1 
ATOM   174  N  N   . ASP A 1 60  ? -0.99022  -40.09657 -35.53807 1.000 61.36820  ? 60  ASP A N   1 
ATOM   175  C  CA  . ASP A 1 60  ? -2.38356  -40.31566 -35.16909 1.000 59.78301  ? 60  ASP A CA  1 
ATOM   176  C  C   . ASP A 1 60  ? -3.33307  -39.27705 -35.75445 1.000 54.10841  ? 60  ASP A C   1 
ATOM   177  O  O   . ASP A 1 60  ? -4.51911  -39.28687 -35.41095 1.000 64.59413  ? 60  ASP A O   1 
ATOM   178  C  CB  . ASP A 1 60  ? -2.52224  -40.33780 -33.64482 1.000 54.44659  ? 60  ASP A CB  1 
ATOM   179  C  CG  . ASP A 1 60  ? -2.00392  -39.07088 -32.99495 1.000 68.01358  ? 60  ASP A CG  1 
ATOM   180  O  OD1 . ASP A 1 60  ? -2.28134  -38.85938 -31.79510 1.000 86.71969  ? 60  ASP A OD1 1 
ATOM   181  O  OD2 . ASP A 1 60  ? -1.31951  -38.28543 -33.68308 1.000 72.94615  ? 60  ASP A OD2 1 
ATOM   182  N  N   . GLY A 1 61  ? -2.85166  -38.38910 -36.62142 1.000 55.67108  ? 61  GLY A N   1 
ATOM   183  C  CA  . GLY A 1 61  ? -3.67001  -37.35898 -37.21616 1.000 48.79592  ? 61  GLY A CA  1 
ATOM   184  C  C   . GLY A 1 61  ? -3.56733  -36.00581 -36.54393 1.000 53.40823  ? 61  GLY A C   1 
ATOM   185  O  O   . GLY A 1 61  ? -3.96186  -34.99990 -37.14476 1.000 63.57904  ? 61  GLY A O   1 
ATOM   186  N  N   . GLN A 1 62  ? -3.05409  -35.95594 -35.31790 1.000 49.74979  ? 62  GLN A N   1 
ATOM   187  C  CA  . GLN A 1 62  ? -2.85803  -34.69248 -34.62861 1.000 51.39820  ? 62  GLN A CA  1 
ATOM   188  C  C   . GLN A 1 62  ? -1.74567  -33.88522 -35.29403 1.000 49.09048  ? 62  GLN A C   1 
ATOM   189  O  O   . GLN A 1 62  ? -0.97693  -34.38580 -36.12009 1.000 48.80480  ? 62  GLN A O   1 
ATOM   190  C  CB  . GLN A 1 62  ? -2.50903  -34.93026 -33.16039 1.000 46.69393  ? 62  GLN A CB  1 
ATOM   191  C  CG  . GLN A 1 62  ? -3.55022  -35.70376 -32.37629 1.000 50.53178  ? 62  GLN A CG  1 
ATOM   192  C  CD  . GLN A 1 62  ? -3.30569  -35.63636 -30.88387 1.000 52.23902  ? 62  GLN A CD  1 
ATOM   193  O  OE1 . GLN A 1 62  ? -3.98553  -34.90593 -30.16626 1.000 69.00795  ? 62  GLN A OE1 1 
ATOM   194  N  NE2 . GLN A 1 62  ? -2.32459  -36.39553 -30.40892 1.000 64.13317  ? 62  GLN A NE2 1 
ATOM   195  N  N   . MET A 1 63  ? -1.66939  -32.61054 -34.92299 1.000 43.69987  ? 63  MET A N   1 
ATOM   196  C  CA  . MET A 1 63  ? -0.54222  -31.76042 -35.27407 1.000 43.81817  ? 63  MET A CA  1 
ATOM   197  C  C   . MET A 1 63  ? -0.00569  -31.12116 -34.00466 1.000 40.70076  ? 63  MET A C   1 
ATOM   198  O  O   . MET A 1 63  ? -0.77607  -30.75061 -33.11444 1.000 52.62118  ? 63  MET A O   1 
ATOM   199  C  CB  . MET A 1 63  ? -0.92349  -30.67721 -36.29377 1.000 39.79962  ? 63  MET A CB  1 
ATOM   200  C  CG  . MET A 1 63  ? -1.98209  -31.09470 -37.29918 1.000 45.15337  ? 63  MET A CG  1 
ATOM   201  S  SD  . MET A 1 63  ? -2.64584  -29.68987 -38.21463 1.000 50.67785  ? 63  MET A SD  1 
ATOM   202  C  CE  . MET A 1 63  ? -2.68597  -30.34950 -39.87815 1.000 47.70662  ? 63  MET A CE  1 
ATOM   203  N  N   . GLY A 1 64  ? 1.31542   -31.00306 -33.91911 1.000 44.62691  ? 64  GLY A N   1 
ATOM   204  C  CA  . GLY A 1 64  ? 1.93510   -30.47947 -32.71797 1.000 37.32924  ? 64  GLY A CA  1 
ATOM   205  C  C   . GLY A 1 64  ? 3.19718   -29.70698 -33.02848 1.000 40.90441  ? 64  GLY A C   1 
ATOM   206  O  O   . GLY A 1 64  ? 3.83434   -29.89738 -34.06914 1.000 42.85889  ? 64  GLY A O   1 
ATOM   207  N  N   . TYR A 1 65  ? 3.54486   -28.81960 -32.10491 1.000 40.36374  ? 65  TYR A N   1 
ATOM   208  C  CA  . TYR A 1 65  ? 4.78548   -28.06566 -32.16507 1.000 35.41541  ? 65  TYR A CA  1 
ATOM   209  C  C   . TYR A 1 65  ? 5.91485   -28.83969 -31.49326 1.000 41.16804  ? 65  TYR A C   1 
ATOM   210  O  O   . TYR A 1 65  ? 5.69169   -29.70333 -30.64138 1.000 41.72428  ? 65  TYR A O   1 
ATOM   211  C  CB  . TYR A 1 65  ? 4.63382   -26.70672 -31.48404 1.000 39.58508  ? 65  TYR A CB  1 
ATOM   212  C  CG  . TYR A 1 65  ? 3.69707   -25.73697 -32.16514 1.000 46.06346  ? 65  TYR A CG  1 
ATOM   213  C  CD1 . TYR A 1 65  ? 4.05855   -25.10673 -33.34927 1.000 39.57318  ? 65  TYR A CD1 1 
ATOM   214  C  CD2 . TYR A 1 65  ? 2.46780   -25.41859 -31.60224 1.000 40.11849  ? 65  TYR A CD2 1 
ATOM   215  C  CE1 . TYR A 1 65  ? 3.21048   -24.20625 -33.96889 1.000 37.98907  ? 65  TYR A CE1 1 
ATOM   216  C  CE2 . TYR A 1 65  ? 1.61520   -24.51601 -32.21256 1.000 48.44643  ? 65  TYR A CE2 1 
ATOM   217  C  CZ  . TYR A 1 65  ? 1.99055   -23.91484 -33.39558 1.000 42.67191  ? 65  TYR A CZ  1 
ATOM   218  O  OH  . TYR A 1 65  ? 1.14529   -23.01722 -34.00596 1.000 46.48986  ? 65  TYR A OH  1 
ATOM   219  N  N   . GLY A 1 66  ? 7.14236   -28.50111 -31.87465 1.000 38.68266  ? 66  GLY A N   1 
ATOM   220  C  CA  . GLY A 1 66  ? 8.30680   -29.12821 -31.28115 1.000 39.48257  ? 66  GLY A CA  1 
ATOM   221  C  C   . GLY A 1 66  ? 9.55676   -28.32479 -31.54793 1.000 41.11577  ? 66  GLY A C   1 
ATOM   222  O  O   . GLY A 1 66  ? 9.63469   -27.55687 -32.51217 1.000 46.89328  ? 66  GLY A O   1 
ATOM   223  N  N   . PHE A 1 67  ? 10.54204  -28.50530 -30.66645 1.000 45.02478  ? 67  PHE A N   1 
ATOM   224  C  CA  . PHE A 1 67  ? 11.84731  -27.88852 -30.86049 1.000 50.01034  ? 67  PHE A CA  1 
ATOM   225  C  C   . PHE A 1 67  ? 12.74229  -28.70372 -31.78279 1.000 47.95281  ? 67  PHE A C   1 
ATOM   226  O  O   . PHE A 1 67  ? 13.70462  -28.15831 -32.33338 1.000 53.68204  ? 67  PHE A O   1 
ATOM   227  C  CB  . PHE A 1 67  ? 12.54633  -27.68863 -29.51337 1.000 44.99981  ? 67  PHE A CB  1 
ATOM   228  C  CG  . PHE A 1 67  ? 11.94394  -26.59973 -28.67066 1.000 51.99915  ? 67  PHE A CG  1 
ATOM   229  C  CD1 . PHE A 1 67  ? 11.28167  -25.53488 -29.25894 1.000 50.63294  ? 67  PHE A CD1 1 
ATOM   230  C  CD2 . PHE A 1 67  ? 12.04668  -26.63751 -27.28928 1.000 41.48943  ? 67  PHE A CD2 1 
ATOM   231  C  CE1 . PHE A 1 67  ? 10.72923  -24.53047 -28.48501 1.000 49.30589  ? 67  PHE A CE1 1 
ATOM   232  C  CE2 . PHE A 1 67  ? 11.49753  -25.63550 -26.51111 1.000 42.39464  ? 67  PHE A CE2 1 
ATOM   233  C  CZ  . PHE A 1 67  ? 10.83779  -24.58112 -27.10974 1.000 44.28262  ? 67  PHE A CZ  1 
ATOM   234  N  N   . GLU A 1 68  ? 12.44732  -29.98873 -31.96194 1.000 44.21487  ? 68  GLU A N   1 
ATOM   235  C  CA  . GLU A 1 68  ? 13.21958  -30.86415 -32.82809 1.000 48.61689  ? 68  GLU A CA  1 
ATOM   236  C  C   . GLU A 1 68  ? 12.27545  -31.63545 -33.73735 1.000 47.72588  ? 68  GLU A C   1 
ATOM   237  O  O   . GLU A 1 68  ? 11.15424  -31.97394 -33.34889 1.000 48.55258  ? 68  GLU A O   1 
ATOM   238  C  CB  . GLU A 1 68  ? 14.07390  -31.84770 -32.01680 1.000 50.12859  ? 68  GLU A CB  1 
ATOM   239  C  CG  . GLU A 1 68  ? 15.27994  -31.21902 -31.34326 1.000 51.40994  ? 68  GLU A CG  1 
ATOM   240  C  CD  . GLU A 1 68  ? 16.00909  -32.18936 -30.43449 1.000 66.14331  ? 68  GLU A CD  1 
ATOM   241  O  OE1 . GLU A 1 68  ? 15.33303  -32.96532 -29.72603 1.000 76.67352  ? 68  GLU A OE1 1 
ATOM   242  O  OE2 . GLU A 1 68  ? 17.25837  -32.17759 -30.42969 1.000 80.98374  ? 68  GLU A OE2 1 
ATOM   243  N  N   . LYS A 1 69  ? 12.73838  -31.90823 -34.95522 1.000 47.35697  ? 69  LYS A N   1 
ATOM   244  C  CA  . LYS A 1 69  ? 11.95361  -32.70963 -35.88421 1.000 43.39894  ? 69  LYS A CA  1 
ATOM   245  C  C   . LYS A 1 69  ? 11.79459  -34.12505 -35.34660 1.000 42.42070  ? 69  LYS A C   1 
ATOM   246  O  O   . LYS A 1 69  ? 12.77244  -34.77008 -34.96017 1.000 50.99076  ? 69  LYS A O   1 
ATOM   247  C  CB  . LYS A 1 69  ? 12.61845  -32.73388 -37.25967 1.000 49.95086  ? 69  LYS A CB  1 
ATOM   248  C  CG  . LYS A 1 69  ? 11.74703  -32.18602 -38.37689 1.000 62.50002  ? 69  LYS A CG  1 
ATOM   249  C  CD  . LYS A 1 69  ? 12.44276  -32.29267 -39.72415 1.000 64.88809  ? 69  LYS A CD  1 
ATOM   250  C  CE  . LYS A 1 69  ? 13.82276  -31.65855 -39.68438 1.000 71.91541  ? 69  LYS A CE  1 
ATOM   251  N  NZ  . LYS A 1 69  ? 14.29471  -31.25711 -41.04051 1.000 74.88166  ? 69  LYS A NZ  1 
ATOM   252  N  N   . GLY A 1 70  ? 10.55624  -34.60628 -35.31959 1.000 48.23663  ? 70  GLY A N   1 
ATOM   253  C  CA  . GLY A 1 70  ? 10.25605  -35.89438 -34.73803 1.000 42.76488  ? 70  GLY A CA  1 
ATOM   254  C  C   . GLY A 1 70  ? 10.02195  -35.87739 -33.24480 1.000 55.17046  ? 70  GLY A C   1 
ATOM   255  O  O   . GLY A 1 70  ? 9.73119   -36.93403 -32.66861 1.000 52.14174  ? 70  GLY A O   1 
ATOM   256  N  N   . LYS A 1 71  ? 10.13277  -34.71833 -32.60032 1.000 53.52607  ? 71  LYS A N   1 
ATOM   257  C  CA  . LYS A 1 71  ? 9.93783   -34.58065 -31.16279 1.000 52.56411  ? 71  LYS A CA  1 
ATOM   258  C  C   . LYS A 1 71  ? 8.84198   -33.56822 -30.84947 1.000 52.78260  ? 71  LYS A C   1 
ATOM   259  O  O   . LYS A 1 71  ? 8.91624   -32.82921 -29.86537 1.000 52.49063  ? 71  LYS A O   1 
ATOM   260  C  CB  . LYS A 1 71  ? 11.24245  -34.18936 -30.47333 1.000 52.49419  ? 71  LYS A CB  1 
ATOM   261  C  CG  . LYS A 1 71  ? 12.23558  -35.32986 -30.33362 1.000 58.41507  ? 71  LYS A CG  1 
ATOM   262  C  CD  . LYS A 1 71  ? 12.12554  -35.98663 -28.96833 1.000 63.44472  ? 71  LYS A CD  1 
ATOM   263  C  CE  . LYS A 1 71  ? 13.31978  -36.88021 -28.69084 1.000 57.85967  ? 71  LYS A CE  1 
ATOM   264  N  NZ  . LYS A 1 71  ? 14.18617  -36.33183 -27.61170 1.000 79.33283  ? 71  LYS A NZ  1 
ATOM   265  N  N   . ALA A 1 72  ? 7.80947   -33.51967 -31.68638 1.000 53.12355  ? 72  ALA A N   1 
ATOM   266  C  CA  . ALA A 1 72  ? 6.68745   -32.63042 -31.42643 1.000 53.01361  ? 72  ALA A CA  1 
ATOM   267  C  C   . ALA A 1 72  ? 5.82277   -33.18199 -30.29795 1.000 50.47544  ? 72  ALA A C   1 
ATOM   268  O  O   . ALA A 1 72  ? 5.74947   -34.39346 -30.07564 1.000 65.51795  ? 72  ALA A O   1 
ATOM   269  C  CB  . ALA A 1 72  ? 5.84863   -32.43797 -32.68958 1.000 40.37795  ? 72  ALA A CB  1 
ATOM   270  N  N   . SER A 1 73  ? 5.16315   -32.27665 -29.57840 1.000 48.50474  ? 73  SER A N   1 
ATOM   271  C  CA  . SER A 1 73  ? 4.36412   -32.65510 -28.42326 1.000 47.28234  ? 73  SER A CA  1 
ATOM   272  C  C   . SER A 1 73  ? 3.06176   -31.86993 -28.40813 1.000 51.90559  ? 73  SER A C   1 
ATOM   273  O  O   . SER A 1 73  ? 2.97847   -30.75876 -28.93818 1.000 44.69518  ? 73  SER A O   1 
ATOM   274  C  CB  . SER A 1 73  ? 5.12168   -32.41778 -27.11008 1.000 47.71605  ? 73  SER A CB  1 
ATOM   275  O  OG  . SER A 1 73  ? 5.43880   -31.04634 -26.94524 1.000 50.53447  ? 73  SER A OG  1 
ATOM   276  N  N   . VAL A 1 74  ? 2.04446   -32.46905 -27.79649 1.000 55.20874  ? 74  VAL A N   1 
ATOM   277  C  CA  . VAL A 1 74  ? 0.77130   -31.80329 -27.53624 1.000 39.82335  ? 74  VAL A CA  1 
ATOM   278  C  C   . VAL A 1 74  ? 0.49589   -31.88466 -26.03930 1.000 49.27530  ? 74  VAL A C   1 
ATOM   279  O  O   . VAL A 1 74  ? 0.26365   -32.98409 -25.51626 1.000 51.52630  ? 74  VAL A O   1 
ATOM   280  C  CB  . VAL A 1 74  ? -0.37332  -32.42673 -28.34856 1.000 45.02649  ? 74  VAL A CB  1 
ATOM   281  C  CG1 . VAL A 1 74  ? -1.68419  -31.72865 -28.02381 1.000 39.79109  ? 74  VAL A CG1 1 
ATOM   282  C  CG2 . VAL A 1 74  ? -0.07630  -32.34131 -29.83953 1.000 38.24727  ? 74  VAL A CG2 1 
ATOM   283  N  N   . PRO A 1 75  ? 0.51177   -30.76230 -25.30581 1.000 46.67835  ? 75  PRO A N   1 
ATOM   284  C  CA  . PRO A 1 75  ? 0.76017   -29.38040 -25.75471 1.000 45.46662  ? 75  PRO A CA  1 
ATOM   285  C  C   . PRO A 1 75  ? 2.19020   -29.15792 -26.23106 1.000 43.87257  ? 75  PRO A C   1 
ATOM   286  O  O   . PRO A 1 75  ? 3.07405   -29.96246 -25.95182 1.000 49.45977  ? 75  PRO A O   1 
ATOM   287  C  CB  . PRO A 1 75  ? 0.45843   -28.54649 -24.49774 1.000 43.59308  ? 75  PRO A CB  1 
ATOM   288  C  CG  . PRO A 1 75  ? 0.66311   -29.49196 -23.35223 1.000 45.10805  ? 75  PRO A CG  1 
ATOM   289  C  CD  . PRO A 1 75  ? 0.18755   -30.81748 -23.87034 1.000 44.23105  ? 75  PRO A CD  1 
ATOM   290  N  N   . GLY A 1 76  ? 2.43792   -28.06919 -26.95467 1.000 40.83136  ? 76  GLY A N   1 
ATOM   291  C  CA  . GLY A 1 76  ? 3.75811   -27.76214 -27.44570 1.000 39.31245  ? 76  GLY A CA  1 
ATOM   292  C  C   . GLY A 1 76  ? 4.74160   -27.50844 -26.32311 1.000 45.67358  ? 76  GLY A C   1 
ATOM   293  O  O   . GLY A 1 76  ? 4.37172   -27.41869 -25.14756 1.000 45.74922  ? 76  GLY A O   1 
ATOM   294  N  N   . PRO A 1 77  ? 6.02172   -27.38713 -26.66821 1.000 45.95966  ? 77  PRO A N   1 
ATOM   295  C  CA  . PRO A 1 77  ? 7.04130   -27.16922 -25.63732 1.000 45.01366  ? 77  PRO A CA  1 
ATOM   296  C  C   . PRO A 1 77  ? 6.83249   -25.84461 -24.92157 1.000 39.80861  ? 77  PRO A C   1 
ATOM   297  O  O   . PRO A 1 77  ? 6.37056   -24.86125 -25.50365 1.000 48.46565  ? 77  PRO A O   1 
ATOM   298  C  CB  . PRO A 1 77  ? 8.35596   -27.17841 -26.42622 1.000 43.60857  ? 77  PRO A CB  1 
ATOM   299  C  CG  . PRO A 1 77  ? 7.96270   -26.86173 -27.83315 1.000 50.87261  ? 77  PRO A CG  1 
ATOM   300  C  CD  . PRO A 1 77  ? 6.59847   -27.45004 -28.02133 1.000 44.13001  ? 77  PRO A CD  1 
ATOM   301  N  N   . LEU A 1 78  ? 7.17523   -25.83248 -23.63789 1.000 43.38199  ? 78  LEU A N   1 
ATOM   302  C  CA  . LEU A 1 78  ? 7.03471   -24.62390 -22.84064 1.000 38.11019  ? 78  LEU A CA  1 
ATOM   303  C  C   . LEU A 1 78  ? 8.12167   -23.62317 -23.20622 1.000 40.30905  ? 78  LEU A C   1 
ATOM   304  O  O   . LEU A 1 78  ? 9.30116   -23.97460 -23.30037 1.000 49.17079  ? 78  LEU A O   1 
ATOM   305  C  CB  . LEU A 1 78  ? 7.10362   -24.95707 -21.35185 1.000 33.37261  ? 78  LEU A CB  1 
ATOM   306  C  CG  . LEU A 1 78  ? 7.37980   -23.77183 -20.42326 1.000 44.16964  ? 78  LEU A CG  1 
ATOM   307  C  CD1 . LEU A 1 78  ? 6.11039   -22.97087 -20.18021 1.000 41.78715  ? 78  LEU A CD1 1 
ATOM   308  C  CD2 . LEU A 1 78  ? 7.98149   -24.23892 -19.10884 1.000 37.29737  ? 78  LEU A CD2 1 
ATOM   309  N  N   . ILE A 1 79  ? 7.71969   -22.37560 -23.41984 1.000 47.11797  ? 79  ILE A N   1 
ATOM   310  C  CA  . ILE A 1 79  ? 8.63944   -21.27156 -23.65906 1.000 39.15676  ? 79  ILE A CA  1 
ATOM   311  C  C   . ILE A 1 79  ? 8.58648   -20.36628 -22.43845 1.000 42.77694  ? 79  ILE A C   1 
ATOM   312  O  O   . ILE A 1 79  ? 7.50869   -19.89557 -22.05365 1.000 48.75763  ? 79  ILE A O   1 
ATOM   313  C  CB  . ILE A 1 79  ? 8.28209   -20.50234 -24.93877 1.000 40.52043  ? 79  ILE A CB  1 
ATOM   314  C  CG1 . ILE A 1 79  ? 8.47679   -21.39443 -26.16644 1.000 40.60398  ? 79  ILE A CG1 1 
ATOM   315  C  CG2 . ILE A 1 79  ? 9.11631   -19.24308 -25.04353 1.000 45.11216  ? 79  ILE A CG2 1 
ATOM   316  C  CD1 . ILE A 1 79  ? 7.75272   -20.90508 -27.39765 1.000 44.84184  ? 79  ILE A CD1 1 
ATOM   317  N  N   . GLU A 1 80  ? 9.74097   -20.12775 -21.82158 1.000 41.68714  ? 80  GLU A N   1 
ATOM   318  C  CA  . GLU A 1 80  ? 9.80727   -19.36184 -20.58367 1.000 49.97240  ? 80  GLU A CA  1 
ATOM   319  C  C   . GLU A 1 80  ? 10.91652  -18.32907 -20.70132 1.000 46.20452  ? 80  GLU A C   1 
ATOM   320  O  O   . GLU A 1 80  ? 12.07851  -18.68405 -20.92176 1.000 61.47775  ? 80  GLU A O   1 
ATOM   321  C  CB  . GLU A 1 80  ? 10.03104  -20.28709 -19.38367 1.000 42.48983  ? 80  GLU A CB  1 
ATOM   322  C  CG  . GLU A 1 80  ? 10.49023  -19.60064 -18.11198 1.000 55.35501  ? 80  GLU A CG  1 
ATOM   323  C  CD  . GLU A 1 80  ? 10.98946  -20.59163 -17.07545 1.000 68.24374  ? 80  GLU A CD  1 
ATOM   324  O  OE1 . GLU A 1 80  ? 11.17034  -21.77930 -17.42110 1.000 73.51059  ? 80  GLU A OE1 1 
ATOM   325  O  OE2 . GLU A 1 80  ? 11.18085  -20.18994 -15.90905 1.000 68.44829  ? 80  GLU A OE2 1 
ATOM   326  N  N   . VAL A 1 81  ? 10.55297  -17.05332 -20.56641 1.000 42.51808  ? 81  VAL A N   1 
ATOM   327  C  CA  . VAL A 1 81  ? 11.48135  -15.93792 -20.69695 1.000 47.34929  ? 81  VAL A CA  1 
ATOM   328  C  C   . VAL A 1 81  ? 11.25287  -14.97343 -19.54033 1.000 47.93149  ? 81  VAL A C   1 
ATOM   329  O  O   . VAL A 1 81  ? 10.30647  -15.10784 -18.76257 1.000 55.25712  ? 81  VAL A O   1 
ATOM   330  C  CB  . VAL A 1 81  ? 11.32529  -15.19696 -22.04292 1.000 47.30063  ? 81  VAL A CB  1 
ATOM   331  C  CG1 . VAL A 1 81  ? 11.46911  -16.16026 -23.20790 1.000 44.40296  ? 81  VAL A CG1 1 
ATOM   332  C  CG2 . VAL A 1 81  ? 9.98201   -14.48353 -22.10019 1.000 43.13882  ? 81  VAL A CG2 1 
ATOM   333  N  N   . ASN A 1 82  ? 12.13665  -13.98634 -19.44040 1.000 43.40738  ? 82  ASN A N   1 
ATOM   334  C  CA  . ASN A 1 82  ? 12.04026  -12.93933 -18.43713 1.000 40.88207  ? 82  ASN A CA  1 
ATOM   335  C  C   . ASN A 1 82  ? 11.64794  -11.62451 -19.09752 1.000 43.14589  ? 82  ASN A C   1 
ATOM   336  O  O   . ASN A 1 82  ? 11.91743  -11.40284 -20.28143 1.000 47.21248  ? 82  ASN A O   1 
ATOM   337  C  CB  . ASN A 1 82  ? 13.36459  -12.77206 -17.68734 1.000 45.65907  ? 82  ASN A CB  1 
ATOM   338  C  CG  . ASN A 1 82  ? 13.79845  -14.04100 -16.98425 1.000 48.86047  ? 82  ASN A CG  1 
ATOM   339  O  OD1 . ASN A 1 82  ? 13.04009  -14.62451 -16.21016 1.000 55.81373  ? 82  ASN A OD1 1 
ATOM   340  N  ND2 . ASN A 1 82  ? 15.02546  -14.47535 -17.24866 1.000 54.79553  ? 82  ASN A ND2 1 
ATOM   341  N  N   . GLU A 1 83  ? 11.00183  -10.75627 -18.32003 1.000 46.53144  ? 83  GLU A N   1 
ATOM   342  C  CA  . GLU A 1 83  ? 10.59986  -9.45011  -18.82721 1.000 45.05824  ? 83  GLU A CA  1 
ATOM   343  C  C   . GLU A 1 83  ? 11.80840  -8.69185  -19.35775 1.000 46.96842  ? 83  GLU A C   1 
ATOM   344  O  O   . GLU A 1 83  ? 12.81891  -8.54392  -18.66474 1.000 54.25915  ? 83  GLU A O   1 
ATOM   345  C  CB  . GLU A 1 83  ? 9.91379   -8.64056  -17.72852 1.000 43.06020  ? 83  GLU A CB  1 
ATOM   346  C  CG  . GLU A 1 83  ? 8.40506   -8.76668  -17.70799 1.000 43.07643  ? 83  GLU A CG  1 
ATOM   347  C  CD  . GLU A 1 83  ? 7.77846   -7.95419  -16.59476 1.000 48.93038  ? 83  GLU A CD  1 
ATOM   348  O  OE1 . GLU A 1 83  ? 8.49422   -7.62629  -15.62449 1.000 46.25320  ? 83  GLU A OE1 1 
ATOM   349  O  OE2 . GLU A 1 83  ? 6.57347   -7.64088  -16.69008 1.000 46.89816  ? 83  GLU A OE2 1 
ATOM   350  N  N   . GLY A 1 84  ? 11.69924  -8.21077  -20.59344 1.000 53.29467  ? 84  GLY A N   1 
ATOM   351  C  CA  . GLY A 1 84  ? 12.78706  -7.55445  -21.27632 1.000 46.08553  ? 84  GLY A CA  1 
ATOM   352  C  C   . GLY A 1 84  ? 13.49287  -8.41904  -22.29893 1.000 45.86394  ? 84  GLY A C   1 
ATOM   353  O  O   . GLY A 1 84  ? 14.17195  -7.88125  -23.18080 1.000 54.79392  ? 84  GLY A O   1 
ATOM   354  N  N   . ASP A 1 85  ? 13.35203  -9.73855  -22.20320 1.000 48.41117  ? 85  ASP A N   1 
ATOM   355  C  CA  . ASP A 1 85  ? 13.95236  -10.62847 -23.18420 1.000 48.38716  ? 85  ASP A CA  1 
ATOM   356  C  C   . ASP A 1 85  ? 13.29183  -10.45551 -24.54577 1.000 48.22782  ? 85  ASP A C   1 
ATOM   357  O  O   . ASP A 1 85  ? 12.11049  -10.11606 -24.65398 1.000 50.15487  ? 85  ASP A O   1 
ATOM   358  C  CB  . ASP A 1 85  ? 13.82913  -12.08891 -22.74389 1.000 43.61397  ? 85  ASP A CB  1 
ATOM   359  C  CG  . ASP A 1 85  ? 14.75901  -12.43911 -21.60024 1.000 52.01447  ? 85  ASP A CG  1 
ATOM   360  O  OD1 . ASP A 1 85  ? 15.61646  -11.60242 -21.24691 1.000 53.60281  ? 85  ASP A OD1 1 
ATOM   361  O  OD2 . ASP A 1 85  ? 14.63242  -13.55733 -21.05647 1.000 49.52878  ? 85  ASP A OD2 1 
ATOM   362  N  N   . THR A 1 86  ? 14.07645  -10.68812 -25.59109 1.000 48.42870  ? 86  THR A N   1 
ATOM   363  C  CA  . THR A 1 86  ? 13.58157  -10.76834 -26.95548 1.000 41.00452  ? 86  THR A CA  1 
ATOM   364  C  C   . THR A 1 86  ? 13.78289  -12.19158 -27.45507 1.000 45.97732  ? 86  THR A C   1 
ATOM   365  O  O   . THR A 1 86  ? 14.82933  -12.80077 -27.21179 1.000 52.54647  ? 86  THR A O   1 
ATOM   366  C  CB  . THR A 1 86  ? 14.30308  -9.77061  -27.86782 1.000 47.63603  ? 86  THR A CB  1 
ATOM   367  O  OG1 . THR A 1 86  ? 14.03659  -8.43550  -27.42000 1.000 66.50439  ? 86  THR A OG1 1 
ATOM   368  C  CG2 . THR A 1 86  ? 13.82969  -9.91452  -29.30483 1.000 44.76443  ? 86  THR A CG2 1 
ATOM   369  N  N   . LEU A 1 87  ? 12.77372  -12.72791 -28.13440 1.000 43.36431  ? 87  LEU A N   1 
ATOM   370  C  CA  . LEU A 1 87  ? 12.78050  -14.11605 -28.57648 1.000 46.42433  ? 87  LEU A CA  1 
ATOM   371  C  C   . LEU A 1 87  ? 12.62244  -14.16550 -30.08850 1.000 50.94406  ? 87  LEU A C   1 
ATOM   372  O  O   . LEU A 1 87  ? 11.63380  -13.65870 -30.62962 1.000 58.77918  ? 87  LEU A O   1 
ATOM   373  C  CB  . LEU A 1 87  ? 11.66689  -14.90920 -27.89162 1.000 51.74696  ? 87  LEU A CB  1 
ATOM   374  C  CG  . LEU A 1 87  ? 11.59651  -16.39655 -28.23171 1.000 61.71425  ? 87  LEU A CG  1 
ATOM   375  C  CD1 . LEU A 1 87  ? 12.91896  -17.08491 -27.93191 1.000 60.40460  ? 87  LEU A CD1 1 
ATOM   376  C  CD2 . LEU A 1 87  ? 10.46447  -17.05064 -27.47009 1.000 55.47111  ? 87  LEU A CD2 1 
ATOM   377  N  N   . HIS A 1 88  ? 13.59530  -14.77173 -30.76388 1.000 51.51883  ? 88  HIS A N   1 
ATOM   378  C  CA  . HIS A 1 88  ? 13.54531  -15.00237 -32.20240 1.000 45.54804  ? 88  HIS A CA  1 
ATOM   379  C  C   . HIS A 1 88  ? 13.28747  -16.48283 -32.44128 1.000 48.09789  ? 88  HIS A C   1 
ATOM   380  O  O   . HIS A 1 88  ? 14.10429  -17.32738 -32.05844 1.000 54.26297  ? 88  HIS A O   1 
ATOM   381  C  CB  . HIS A 1 88  ? 14.84398  -14.56359 -32.87899 1.000 43.97935  ? 88  HIS A CB  1 
ATOM   382  C  CG  . HIS A 1 88  ? 15.11474  -13.09543 -32.77221 1.000 46.60097  ? 88  HIS A CG  1 
ATOM   383  N  ND1 . HIS A 1 88  ? 14.29352  -12.14482 -33.33956 1.000 47.87785  ? 88  HIS A ND1 1 
ATOM   384  C  CD2 . HIS A 1 88  ? 16.11603  -12.41441 -32.16657 1.000 43.98378  ? 88  HIS A CD2 1 
ATOM   385  C  CE1 . HIS A 1 88  ? 14.77591  -10.94136 -33.08606 1.000 49.45624  ? 88  HIS A CE1 1 
ATOM   386  N  NE2 . HIS A 1 88  ? 15.88134  -11.07683 -32.37599 1.000 50.13546  ? 88  HIS A NE2 1 
ATOM   387  N  N   . ILE A 1 89  ? 12.15745  -16.79386 -33.06707 1.000 49.13903  ? 89  ILE A N   1 
ATOM   388  C  CA  . ILE A 1 89  ? 11.73006  -18.16947 -33.29060 1.000 43.52658  ? 89  ILE A CA  1 
ATOM   389  C  C   . ILE A 1 89  ? 11.77854  -18.44016 -34.78649 1.000 45.67253  ? 89  ILE A C   1 
ATOM   390  O  O   . ILE A 1 89  ? 10.96016  -17.91190 -35.54931 1.000 51.63291  ? 89  ILE A O   1 
ATOM   391  C  CB  . ILE A 1 89  ? 10.32553  -18.43011 -32.73079 1.000 47.36969  ? 89  ILE A CB  1 
ATOM   392  C  CG1 . ILE A 1 89  ? 10.28413  -18.14412 -31.22853 1.000 46.08310  ? 89  ILE A CG1 1 
ATOM   393  C  CG2 . ILE A 1 89  ? 9.89590   -19.85752 -33.02353 1.000 39.16737  ? 89  ILE A CG2 1 
ATOM   394  C  CD1 . ILE A 1 89  ? 8.97380   -18.52376 -30.57154 1.000 49.82616  ? 89  ILE A CD1 1 
ATOM   395  N  N   . GLU A 1 90  ? 12.73352  -19.26421 -35.21003 1.000 49.64066  ? 90  GLU A N   1 
ATOM   396  C  CA  . GLU A 1 90  ? 12.78055  -19.74302 -36.58937 1.000 45.26942  ? 90  GLU A CA  1 
ATOM   397  C  C   . GLU A 1 90  ? 11.78285  -20.88657 -36.71411 1.000 41.80751  ? 90  GLU A C   1 
ATOM   398  O  O   . GLU A 1 90  ? 12.06164  -22.01950 -36.31574 1.000 52.84010  ? 90  GLU A O   1 
ATOM   399  C  CB  . GLU A 1 90  ? 14.18995  -20.18340 -36.96618 1.000 50.97787  ? 90  GLU A CB  1 
ATOM   400  C  CG  . GLU A 1 90  ? 14.36091  -20.47065 -38.44864 1.000 63.86765  ? 90  GLU A CG  1 
ATOM   401  C  CD  . GLU A 1 90  ? 15.75579  -20.94730 -38.79904 1.000 70.57061  ? 90  GLU A CD  1 
ATOM   402  O  OE1 . GLU A 1 90  ? 16.73225  -20.28215 -38.39399 1.000 76.97641  ? 90  GLU A OE1 1 
ATOM   403  O  OE2 . GLU A 1 90  ? 15.87557  -21.98572 -39.48305 1.000 77.04847  ? 90  GLU A OE2 1 
ATOM   404  N  N   . PHE A 1 91  ? 10.60949  -20.58870 -37.26129 1.000 47.51700  ? 91  PHE A N   1 
ATOM   405  C  CA  . PHE A 1 91  ? 9.50630   -21.53684 -37.32379 1.000 45.95717  ? 91  PHE A CA  1 
ATOM   406  C  C   . PHE A 1 91  ? 9.44726   -22.16967 -38.70740 1.000 48.61137  ? 91  PHE A C   1 
ATOM   407  O  O   . PHE A 1 91  ? 9.36710   -21.46133 -39.71642 1.000 56.44411  ? 91  PHE A O   1 
ATOM   408  C  CB  . PHE A 1 91  ? 8.18450   -20.84090 -36.99629 1.000 40.18094  ? 91  PHE A CB  1 
ATOM   409  C  CG  . PHE A 1 91  ? 6.97154   -21.69044 -37.24059 1.000 48.26276  ? 91  PHE A CG  1 
ATOM   410  C  CD1 . PHE A 1 91  ? 6.76136   -22.84934 -36.51401 1.000 40.78229  ? 91  PHE A CD1 1 
ATOM   411  C  CD2 . PHE A 1 91  ? 6.03310   -21.32122 -38.18764 1.000 44.22373  ? 91  PHE A CD2 1 
ATOM   412  C  CE1 . PHE A 1 91  ? 5.64077   -23.62753 -36.73515 1.000 44.62543  ? 91  PHE A CE1 1 
ATOM   413  C  CE2 . PHE A 1 91  ? 4.91092   -22.09416 -38.41355 1.000 48.49684  ? 91  PHE A CE2 1 
ATOM   414  C  CZ  . PHE A 1 91  ? 4.71411   -23.24824 -37.68669 1.000 43.45540  ? 91  PHE A CZ  1 
ATOM   415  N  N   . THR A 1 92  ? 9.48484   -23.49921 -38.74988 1.000 44.52922  ? 92  THR A N   1 
ATOM   416  C  CA  . THR A 1 92  ? 9.43316   -24.25419 -39.99460 1.000 45.53932  ? 92  THR A CA  1 
ATOM   417  C  C   . THR A 1 92  ? 8.16293   -25.09100 -40.02160 1.000 43.38562  ? 92  THR A C   1 
ATOM   418  O  O   . THR A 1 92  ? 7.90565   -25.86599 -39.09495 1.000 46.34307  ? 92  THR A O   1 
ATOM   419  C  CB  . THR A 1 92  ? 10.66224  -25.15544 -40.15050 1.000 47.55756  ? 92  THR A CB  1 
ATOM   420  O  OG1 . THR A 1 92  ? 11.83252  -24.34634 -40.31837 1.000 47.53414  ? 92  THR A OG1 1 
ATOM   421  C  CG2 . THR A 1 92  ? 10.50711  -26.06216 -41.36027 1.000 35.37671  ? 92  THR A CG2 1 
ATOM   422  N  N   . ASN A 1 93  ? 7.37621   -24.93515 -41.08386 1.000 45.59654  ? 93  ASN A N   1 
ATOM   423  C  CA  . ASN A 1 93  ? 6.11472   -25.65677 -41.24142 1.000 44.71548  ? 93  ASN A CA  1 
ATOM   424  C  C   . ASN A 1 93  ? 6.37732   -26.90118 -42.08217 1.000 49.30792  ? 93  ASN A C   1 
ATOM   425  O  O   . ASN A 1 93  ? 6.36871   -26.84577 -43.31298 1.000 54.76411  ? 93  ASN A O   1 
ATOM   426  C  CB  . ASN A 1 93  ? 5.06383   -24.75638 -41.88223 1.000 41.86691  ? 93  ASN A CB  1 
ATOM   427  C  CG  . ASN A 1 93  ? 3.73430   -25.45848 -42.09087 1.000 51.32384  ? 93  ASN A CG  1 
ATOM   428  O  OD1 . ASN A 1 93  ? 3.49300   -26.53521 -41.54715 1.000 47.09703  ? 93  ASN A OD1 1 
ATOM   429  N  ND2 . ASN A 1 93  ? 2.86486   -24.84994 -42.89088 1.000 47.87914  ? 93  ASN A ND2 1 
ATOM   430  N  N   . THR A 1 94  ? 6.60573   -28.03295 -41.41745 1.000 46.33218  ? 94  THR A N   1 
ATOM   431  C  CA  . THR A 1 94  ? 6.85402   -29.29213 -42.11033 1.000 42.59690  ? 94  THR A CA  1 
ATOM   432  C  C   . THR A 1 94  ? 5.58648   -29.92326 -42.66626 1.000 39.57951  ? 94  THR A C   1 
ATOM   433  O  O   . THR A 1 94  ? 5.66745   -30.97150 -43.31551 1.000 57.90032  ? 94  THR A O   1 
ATOM   434  C  CB  . THR A 1 94  ? 7.53857   -30.28987 -41.17175 1.000 36.49738  ? 94  THR A CB  1 
ATOM   435  O  OG1 . THR A 1 94  ? 6.55646   -30.90168 -40.32626 1.000 46.17809  ? 94  THR A OG1 1 
ATOM   436  C  CG2 . THR A 1 94  ? 8.57471   -29.58675 -40.30949 1.000 44.43189  ? 94  THR A CG2 1 
ATOM   437  N  N   . MET A 1 95  ? 4.43182   -29.31378 -42.43575 1.000 52.42870  ? 95  MET A N   1 
ATOM   438  C  CA  . MET A 1 95  ? 3.15037   -29.90050 -42.78513 1.000 43.93256  ? 95  MET A CA  1 
ATOM   439  C  C   . MET A 1 95  ? 2.78438   -29.56008 -44.23073 1.000 57.32213  ? 95  MET A C   1 
ATOM   440  O  O   . MET A 1 95  ? 3.40526   -28.71032 -44.87316 1.000 53.84240  ? 95  MET A O   1 
ATOM   441  C  CB  . MET A 1 95  ? 2.08408   -29.40602 -41.81093 1.000 42.56042  ? 95  MET A CB  1 
ATOM   442  C  CG  . MET A 1 95  ? 1.97388   -30.25572 -40.55660 1.000 52.80732  ? 95  MET A CG  1 
ATOM   443  S  SD  . MET A 1 95  ? 0.74303   -29.63851 -39.39976 1.000 53.91916  ? 95  MET A SD  1 
ATOM   444  C  CE  . MET A 1 95  ? 0.99427   -27.87508 -39.54612 1.000 46.10081  ? 95  MET A CE  1 
ATOM   445  N  N   . ASP A 1 96  ? 1.76311   -30.24358 -44.74799 1.000 53.84367  ? 96  ASP A N   1 
ATOM   446  C  CA  . ASP A 1 96  ? 1.30705   -30.03408 -46.11742 1.000 57.70212  ? 96  ASP A CA  1 
ATOM   447  C  C   . ASP A 1 96  ? 0.20532   -28.98547 -46.22258 1.000 58.24855  ? 96  ASP A C   1 
ATOM   448  O  O   . ASP A 1 96  ? -0.39969  -28.84492 -47.29032 1.000 60.64917  ? 96  ASP A O   1 
ATOM   449  C  CB  . ASP A 1 96  ? 0.82852   -31.35569 -46.73087 1.000 46.26169  ? 96  ASP A CB  1 
ATOM   450  C  CG  . ASP A 1 96  ? -0.31868  -31.97966 -45.96198 1.000 66.64830  ? 96  ASP A CG  1 
ATOM   451  O  OD1 . ASP A 1 96  ? -0.61339  -31.51308 -44.84256 1.000 70.81240  ? 96  ASP A OD1 1 
ATOM   452  O  OD2 . ASP A 1 96  ? -0.92288  -32.94459 -46.47779 1.000 65.79111  ? 96  ASP A OD2 1 
ATOM   453  N  N   . VAL A 1 97  ? -0.07214  -28.25561 -45.14213 1.000 57.19766  ? 97  VAL A N   1 
ATOM   454  C  CA  . VAL A 1 97  ? -1.04390  -27.17220 -45.14539 1.000 54.19712  ? 97  VAL A CA  1 
ATOM   455  C  C   . VAL A 1 97  ? -0.40185  -25.95164 -44.50301 1.000 48.89787  ? 97  VAL A C   1 
ATOM   456  O  O   . VAL A 1 97  ? 0.61666   -26.04426 -43.81487 1.000 54.00696  ? 97  VAL A O   1 
ATOM   457  C  CB  . VAL A 1 97  ? -2.34886  -27.54205 -44.40708 1.000 49.93109  ? 97  VAL A CB  1 
ATOM   458  C  CG1 . VAL A 1 97  ? -3.06186  -28.67935 -45.11914 1.000 55.91500  ? 97  VAL A CG1 1 
ATOM   459  C  CG2 . VAL A 1 97  ? -2.05228  -27.91168 -42.96126 1.000 54.75554  ? 97  VAL A CG2 1 
ATOM   460  N  N   . ARG A 1 98  ? -1.01493  -24.79565 -44.73865 1.000 55.80857  ? 98  ARG A N   1 
ATOM   461  C  CA  . ARG A 1 98  ? -0.51341  -23.55399 -44.16637 1.000 56.77384  ? 98  ARG A CA  1 
ATOM   462  C  C   . ARG A 1 98  ? -0.66726  -23.57146 -42.65032 1.000 52.61528  ? 98  ARG A C   1 
ATOM   463  O  O   . ARG A 1 98  ? -1.73024  -23.91800 -42.12810 1.000 52.81407  ? 98  ARG A O   1 
ATOM   464  C  CB  . ARG A 1 98  ? -1.25704  -22.35993 -44.76189 1.000 60.69936  ? 98  ARG A CB  1 
ATOM   465  C  CG  . ARG A 1 98  ? -0.68106  -21.86911 -46.07668 1.000 59.52821  ? 98  ARG A CG  1 
ATOM   466  C  CD  . ARG A 1 98  ? -1.33838  -20.57049 -46.51900 1.000 60.87150  ? 98  ARG A CD  1 
ATOM   467  N  NE  . ARG A 1 98  ? -0.44671  -19.42488 -46.37290 1.000 71.69670  ? 98  ARG A NE  1 
ATOM   468  C  CZ  . ARG A 1 98  ? 0.62394   -19.19816 -47.12285 1.000 68.85500  ? 98  ARG A CZ  1 
ATOM   469  N  NH1 . ARG A 1 98  ? 0.96222   -20.01034 -48.11144 1.000 68.84562  ? 98  ARG A NH1 1 
ATOM   470  N  NH2 . ARG A 1 98  ? 1.37231   -18.12596 -46.87710 1.000 69.42514  ? 98  ARG A NH2 1 
ATOM   471  N  N   . ALA A 1 99  ? 0.39991   -23.20234 -41.94475 1.000 47.04486  ? 99  ALA A N   1 
ATOM   472  C  CA  . ALA A 1 99  ? 0.39361   -23.13248 -40.49096 1.000 44.38275  ? 99  ALA A CA  1 
ATOM   473  C  C   . ALA A 1 99  ? 1.01269   -21.81015 -40.06267 1.000 49.87379  ? 99  ALA A C   1 
ATOM   474  O  O   . ALA A 1 99  ? 1.61653   -21.09360 -40.86576 1.000 48.16895  ? 99  ALA A O   1 
ATOM   475  C  CB  . ALA A 1 99  ? 1.14379   -24.31162 -39.86264 1.000 47.80259  ? 99  ALA A CB  1 
ATOM   476  N  N   . SER A 1 100 ? 0.86293   -21.48614 -38.78189 1.000 43.60432  ? 100 SER A N   1 
ATOM   477  C  CA  . SER A 1 100 ? 1.35586   -20.21453 -38.27088 1.000 43.13372  ? 100 SER A CA  1 
ATOM   478  C  C   . SER A 1 100 ? 1.60215   -20.33791 -36.77260 1.000 49.67688  ? 100 SER A C   1 
ATOM   479  O  O   . SER A 1 100 ? 1.35658   -21.38129 -36.16045 1.000 45.42371  ? 100 SER A O   1 
ATOM   480  C  CB  . SER A 1 100 ? 0.37413   -19.08276 -38.57786 1.000 48.72645  ? 100 SER A CB  1 
ATOM   481  O  OG  . SER A 1 100 ? -0.71259  -19.09396 -37.66774 1.000 44.75816  ? 100 SER A OG  1 
ATOM   482  N  N   . LEU A 1 101 ? 2.08757   -19.24509 -36.18693 1.000 46.51316  ? 101 LEU A N   1 
ATOM   483  C  CA  . LEU A 1 101 ? 2.39337   -19.16906 -34.76132 1.000 36.86699  ? 101 LEU A CA  1 
ATOM   484  C  C   . LEU A 1 101 ? 1.88900   -17.82662 -34.25254 1.000 46.95642  ? 101 LEU A C   1 
ATOM   485  O  O   . LEU A 1 101 ? 2.41042   -16.77841 -34.64628 1.000 50.30855  ? 101 LEU A O   1 
ATOM   486  C  CB  . LEU A 1 101 ? 3.89458   -19.31860 -34.51246 1.000 49.66154  ? 101 LEU A CB  1 
ATOM   487  C  CG  . LEU A 1 101 ? 4.36874   -19.75567 -33.12692 1.000 49.80103  ? 101 LEU A CG  1 
ATOM   488  C  CD1 . LEU A 1 101 ? 3.49693   -20.87202 -32.59002 1.000 43.85461  ? 101 LEU A CD1 1 
ATOM   489  C  CD2 . LEU A 1 101 ? 5.82872   -20.18523 -33.17995 1.000 49.66901  ? 101 LEU A CD2 1 
ATOM   490  N  N   . HIS A 1 102 ? 0.87840   -17.85371 -33.38804 1.000 43.27881  ? 102 HIS A N   1 
ATOM   491  C  CA  . HIS A 1 102 ? 0.30590   -16.64618 -32.80929 1.000 45.85026  ? 102 HIS A CA  1 
ATOM   492  C  C   . HIS A 1 102 ? 0.39489   -16.72723 -31.29184 1.000 42.55964  ? 102 HIS A C   1 
ATOM   493  O  O   . HIS A 1 102 ? 0.00992   -17.73995 -30.69901 1.000 43.43301  ? 102 HIS A O   1 
ATOM   494  C  CB  . HIS A 1 102 ? -1.14724  -16.46245 -33.24812 1.000 47.32770  ? 102 HIS A CB  1 
ATOM   495  C  CG  . HIS A 1 102 ? -1.81813  -15.28423 -32.61802 1.000 51.24381  ? 102 HIS A CG  1 
ATOM   496  N  ND1 . HIS A 1 102 ? -1.52492  -13.98547 -32.97404 1.000 55.87579  ? 102 HIS A ND1 1 
ATOM   497  C  CD2 . HIS A 1 102 ? -2.75720  -15.20578 -31.64648 1.000 45.40948  ? 102 HIS A CD2 1 
ATOM   498  C  CE1 . HIS A 1 102 ? -2.25976  -13.15766 -32.25376 1.000 51.80985  ? 102 HIS A CE1 1 
ATOM   499  N  NE2 . HIS A 1 102 ? -3.01492  -13.87276 -31.44032 1.000 44.00423  ? 102 HIS A NE2 1 
ATOM   500  N  N   . VAL A 1 103 ? 0.88993   -15.66020 -30.66697 1.000 32.05651  ? 103 VAL A N   1 
ATOM   501  C  CA  . VAL A 1 103 ? 1.13926   -15.64151 -29.23130 1.000 37.62679  ? 103 VAL A CA  1 
ATOM   502  C  C   . VAL A 1 103 ? 0.26398   -14.58115 -28.57480 1.000 46.16237  ? 103 VAL A C   1 
ATOM   503  O  O   . VAL A 1 103 ? -0.10947  -13.57868 -29.19390 1.000 43.97028  ? 103 VAL A O   1 
ATOM   504  C  CB  . VAL A 1 103 ? 2.63406   -15.39361 -28.92202 1.000 36.17868  ? 103 VAL A CB  1 
ATOM   505  C  CG1 . VAL A 1 103 ? 3.01604   -13.94723 -29.21076 1.000 35.77175  ? 103 VAL A CG1 1 
ATOM   506  C  CG2 . VAL A 1 103 ? 2.96477   -15.78071 -27.48434 1.000 35.75062  ? 103 VAL A CG2 1 
ATOM   507  N  N   . HIS A 1 104 ? -0.06689  -14.81787 -27.30733 1.000 41.02333  ? 104 HIS A N   1 
ATOM   508  C  CA  . HIS A 1 104 ? -0.86223  -13.90599 -26.50025 1.000 38.87637  ? 104 HIS A CA  1 
ATOM   509  C  C   . HIS A 1 104 ? 0.03183   -13.10672 -25.55987 1.000 43.52384  ? 104 HIS A C   1 
ATOM   510  O  O   . HIS A 1 104 ? 1.06682   -13.59152 -25.09580 1.000 42.41091  ? 104 HIS A O   1 
ATOM   511  C  CB  . HIS A 1 104 ? -1.90285  -14.67139 -25.67807 1.000 39.53226  ? 104 HIS A CB  1 
ATOM   512  C  CG  . HIS A 1 104 ? -3.08023  -15.14345 -26.47213 1.000 44.29883  ? 104 HIS A CG  1 
ATOM   513  N  ND1 . HIS A 1 104 ? -4.37234  -14.75630 -26.18762 1.000 45.24883  ? 104 HIS A ND1 1 
ATOM   514  C  CD2 . HIS A 1 104 ? -3.16276  -15.97469 -27.53753 1.000 44.84000  ? 104 HIS A CD2 1 
ATOM   515  C  CE1 . HIS A 1 104 ? -5.19967  -15.32706 -27.04465 1.000 42.84871  ? 104 HIS A CE1 1 
ATOM   516  N  NE2 . HIS A 1 104 ? -4.49107  -16.07122 -27.87443 1.000 45.16034  ? 104 HIS A NE2 1 
ATOM   517  N  N   . GLY A 1 105 ? -0.37833  -11.86953 -25.28701 1.000 43.55997  ? 105 GLY A N   1 
ATOM   518  C  CA  . GLY A 1 105 ? 0.24770   -11.06137 -24.25609 1.000 42.42513  ? 105 GLY A CA  1 
ATOM   519  C  C   . GLY A 1 105 ? 1.59430   -10.45342 -24.59352 1.000 46.52262  ? 105 GLY A C   1 
ATOM   520  O  O   . GLY A 1 105 ? 1.89482   -9.33444  -24.16690 1.000 50.24854  ? 105 GLY A O   1 
ATOM   521  N  N   . LEU A 1 106 ? 2.41903   -11.17481 -25.34486 1.000 49.40537  ? 106 LEU A N   1 
ATOM   522  C  CA  . LEU A 1 106 ? 3.75370   -10.69341 -25.65957 1.000 48.00678  ? 106 LEU A CA  1 
ATOM   523  C  C   . LEU A 1 106 ? 3.69809   -9.62841  -26.75213 1.000 52.43411  ? 106 LEU A C   1 
ATOM   524  O  O   . LEU A 1 106 ? 2.73832   -9.53877  -27.52288 1.000 48.48613  ? 106 LEU A O   1 
ATOM   525  C  CB  . LEU A 1 106 ? 4.65369   -11.84963 -26.09824 1.000 40.34656  ? 106 LEU A CB  1 
ATOM   526  C  CG  . LEU A 1 106 ? 5.28747   -12.70873 -24.99913 1.000 53.24235  ? 106 LEU A CG  1 
ATOM   527  C  CD1 . LEU A 1 106 ? 4.25199   -13.57316 -24.29343 1.000 41.88944  ? 106 LEU A CD1 1 
ATOM   528  C  CD2 . LEU A 1 106 ? 6.39999   -13.57207 -25.57097 1.000 44.56467  ? 106 LEU A CD2 1 
ATOM   529  N  N   . ASP A 1 107 ? 4.74715   -8.80975  -26.80763 1.000 39.35674  ? 107 ASP A N   1 
ATOM   530  C  CA  . ASP A 1 107 ? 4.86404   -7.80158  -27.85273 1.000 41.34807  ? 107 ASP A CA  1 
ATOM   531  C  C   . ASP A 1 107 ? 5.32850   -8.44906  -29.15064 1.000 45.52489  ? 107 ASP A C   1 
ATOM   532  O  O   . ASP A 1 107 ? 6.25857   -9.26166  -29.15212 1.000 57.30690  ? 107 ASP A O   1 
ATOM   533  C  CB  . ASP A 1 107 ? 5.84221   -6.70001  -27.44319 1.000 39.22141  ? 107 ASP A CB  1 
ATOM   534  C  CG  . ASP A 1 107 ? 5.53885   -6.12349  -26.07582 1.000 53.82834  ? 107 ASP A CG  1 
ATOM   535  O  OD1 . ASP A 1 107 ? 4.34519   -5.94750  -25.75192 1.000 56.26871  ? 107 ASP A OD1 1 
ATOM   536  O  OD2 . ASP A 1 107 ? 6.49791   -5.83814  -25.32708 1.000 57.75219  ? 107 ASP A OD2 1 
ATOM   537  N  N   . TYR A 1 108 ? 4.67954   -8.08809  -30.25414 1.000 42.35698  ? 108 TYR A N   1 
ATOM   538  C  CA  . TYR A 1 108 ? 5.09435   -8.55324  -31.56896 1.000 46.58564  ? 108 TYR A CA  1 
ATOM   539  C  C   . TYR A 1 108 ? 4.59192   -7.56528  -32.60909 1.000 45.07142  ? 108 TYR A C   1 
ATOM   540  O  O   . TYR A 1 108 ? 3.49767   -7.01482  -32.46976 1.000 43.73445  ? 108 TYR A O   1 
ATOM   541  C  CB  . TYR A 1 108 ? 4.56269   -9.96052  -31.87205 1.000 45.07227  ? 108 TYR A CB  1 
ATOM   542  C  CG  . TYR A 1 108 ? 3.06025   -10.09719 -31.75903 1.000 46.86742  ? 108 TYR A CG  1 
ATOM   543  C  CD1 . TYR A 1 108 ? 2.46205   -10.41346 -30.54704 1.000 46.09525  ? 108 TYR A CD1 1 
ATOM   544  C  CD2 . TYR A 1 108 ? 2.24053   -9.91506  -32.86678 1.000 43.30659  ? 108 TYR A CD2 1 
ATOM   545  C  CE1 . TYR A 1 108 ? 1.09032   -10.54016 -30.43805 1.000 51.66577  ? 108 TYR A CE1 1 
ATOM   546  C  CE2 . TYR A 1 108 ? 0.86801   -10.03998 -32.76781 1.000 45.28878  ? 108 TYR A CE2 1 
ATOM   547  C  CZ  . TYR A 1 108 ? 0.29849   -10.35214 -31.55072 1.000 50.28094  ? 108 TYR A CZ  1 
ATOM   548  O  OH  . TYR A 1 108 ? -1.06724  -10.47784 -31.44393 1.000 54.60469  ? 108 TYR A OH  1 
ATOM   549  N  N   . GLU A 1 109 ? 5.39623   -7.34314  -33.64333 1.000 52.13740  ? 109 GLU A N   1 
ATOM   550  C  CA  . GLU A 1 109 ? 4.96479   -6.48826  -34.73427 1.000 42.64714  ? 109 GLU A CA  1 
ATOM   551  C  C   . GLU A 1 109 ? 3.92296   -7.21084  -35.58538 1.000 44.90672  ? 109 GLU A C   1 
ATOM   552  O  O   . GLU A 1 109 ? 3.68946   -8.41584  -35.44733 1.000 52.55334  ? 109 GLU A O   1 
ATOM   553  C  CB  . GLU A 1 109 ? 6.15949   -6.05960  -35.58396 1.000 44.28534  ? 109 GLU A CB  1 
ATOM   554  C  CG  . GLU A 1 109 ? 7.13250   -5.15246  -34.84965 1.000 51.39491  ? 109 GLU A CG  1 
ATOM   555  C  CD  . GLU A 1 109 ? 8.21926   -4.60779  -35.75249 1.000 70.88646  ? 109 GLU A CD  1 
ATOM   556  O  OE1 . GLU A 1 109 ? 8.77124   -5.38834  -36.55690 1.000 84.58447  ? 109 GLU A OE1 1 
ATOM   557  O  OE2 . GLU A 1 109 ? 8.52093   -3.39866  -35.65829 1.000 84.41187  ? 109 GLU A OE2 1 
ATOM   558  N  N   . ILE A 1 110 ? 3.29112   -6.44974  -36.48243 1.000 43.22260  ? 110 ILE A N   1 
ATOM   559  C  CA  . ILE A 1 110 ? 2.22571   -7.00181  -37.31419 1.000 43.32804  ? 110 ILE A CA  1 
ATOM   560  C  C   . ILE A 1 110 ? 2.74761   -8.12960  -38.19560 1.000 50.67459  ? 110 ILE A C   1 
ATOM   561  O  O   . ILE A 1 110 ? 1.98182   -9.00800  -38.61141 1.000 46.48857  ? 110 ILE A O   1 
ATOM   562  C  CB  . ILE A 1 110 ? 1.57298   -5.87888  -38.14669 1.000 53.02894  ? 110 ILE A CB  1 
ATOM   563  C  CG1 . ILE A 1 110 ? 0.10583   -6.20122  -38.42343 1.000 53.64152  ? 110 ILE A CG1 1 
ATOM   564  C  CG2 . ILE A 1 110 ? 2.32495   -5.65369  -39.45292 1.000 43.99208  ? 110 ILE A CG2 1 
ATOM   565  C  CD1 . ILE A 1 110 ? -0.76294  -6.18796  -37.18721 1.000 56.54224  ? 110 ILE A CD1 1 
ATOM   566  N  N   . SER A 1 111 ? 4.05247   -8.13929  -38.48074 1.000 54.54243  ? 111 SER A N   1 
ATOM   567  C  CA  . SER A 1 111 ? 4.64615   -9.18645  -39.30230 1.000 47.93021  ? 111 SER A CA  1 
ATOM   568  C  C   . SER A 1 111 ? 4.77242   -10.51393 -38.56738 1.000 50.48785  ? 111 SER A C   1 
ATOM   569  O  O   . SER A 1 111 ? 5.01668   -11.53778 -39.21486 1.000 51.43397  ? 111 SER A O   1 
ATOM   570  C  CB  . SER A 1 111 ? 6.01968   -8.73918  -39.80482 1.000 42.15880  ? 111 SER A CB  1 
ATOM   571  O  OG  . SER A 1 111 ? 6.74827   -8.08559  -38.77900 1.000 55.43658  ? 111 SER A OG  1 
ATOM   572  N  N   . SER A 1 112 ? 4.62581   -10.52154 -37.24187 1.000 48.29032  ? 112 SER A N   1 
ATOM   573  C  CA  . SER A 1 112 ? 4.59822   -11.74987 -36.45872 1.000 43.91766  ? 112 SER A CA  1 
ATOM   574  C  C   . SER A 1 112 ? 3.20389   -12.04387 -35.91492 1.000 54.88909  ? 112 SER A C   1 
ATOM   575  O  O   . SER A 1 112 ? 3.06787   -12.73774 -34.90212 1.000 49.76267  ? 112 SER A O   1 
ATOM   576  C  CB  . SER A 1 112 ? 5.61556   -11.67897 -35.31869 1.000 52.64070  ? 112 SER A CB  1 
ATOM   577  O  OG  . SER A 1 112 ? 6.94409   -11.67100 -35.81791 1.000 50.18275  ? 112 SER A OG  1 
ATOM   578  N  N   . ASP A 1 113 ? 2.16596   -11.51733 -36.57124 1.000 48.53522  ? 113 ASP A N   1 
ATOM   579  C  CA  . ASP A 1 113 ? 0.79405   -11.76402 -36.13853 1.000 47.71247  ? 113 ASP A CA  1 
ATOM   580  C  C   . ASP A 1 113 ? 0.43890   -13.24374 -36.22043 1.000 53.29539  ? 113 ASP A C   1 
ATOM   581  O  O   . ASP A 1 113 ? -0.32438  -13.75331 -35.39166 1.000 47.35891  ? 113 ASP A O   1 
ATOM   582  C  CB  . ASP A 1 113 ? -0.17000  -10.93352 -36.98807 1.000 57.86901  ? 113 ASP A CB  1 
ATOM   583  C  CG  . ASP A 1 113 ? -1.48521  -10.65725 -36.28566 1.000 61.88596  ? 113 ASP A CG  1 
ATOM   584  O  OD1 . ASP A 1 113 ? -1.49605  -10.56435 -35.03939 1.000 70.20837  ? 113 ASP A OD1 1 
ATOM   585  O  OD2 . ASP A 1 113 ? -2.51021  -10.52257 -36.98709 1.000 65.71561  ? 113 ASP A OD2 1 
ATOM   586  N  N   . GLY A 1 114 ? 0.98440   -13.95018 -37.20682 1.000 47.36720  ? 114 GLY A N   1 
ATOM   587  C  CA  . GLY A 1 114 ? 0.60337   -15.32819 -37.43202 1.000 42.62292  ? 114 GLY A CA  1 
ATOM   588  C  C   . GLY A 1 114 ? -0.74335  -15.50569 -38.09046 1.000 48.13321  ? 114 GLY A C   1 
ATOM   589  O  O   . GLY A 1 114 ? -1.34161  -16.57845 -37.97462 1.000 54.18491  ? 114 GLY A O   1 
ATOM   590  N  N   . THR A 1 115 ? -1.24450  -14.48617 -38.77824 1.000 49.50282  ? 115 THR A N   1 
ATOM   591  C  CA  . THR A 1 115 ? -2.54228  -14.54260 -39.43029 1.000 51.64796  ? 115 THR A CA  1 
ATOM   592  C  C   . THR A 1 115 ? -2.37416  -14.50446 -40.94320 1.000 51.12100  ? 115 THR A C   1 
ATOM   593  O  O   . THR A 1 115 ? -1.39220  -13.96788 -41.46427 1.000 53.92032  ? 115 THR A O   1 
ATOM   594  C  CB  . THR A 1 115 ? -3.43611  -13.38236 -38.98280 1.000 50.53535  ? 115 THR A CB  1 
ATOM   595  O  OG1 . THR A 1 115 ? -2.77711  -12.13832 -39.25330 1.000 57.37262  ? 115 THR A OG1 1 
ATOM   596  C  CG2 . THR A 1 115 ? -3.73253  -13.48241 -37.49396 1.000 46.06896  ? 115 THR A CG2 1 
ATOM   597  N  N   . ALA A 1 116 ? -3.34662  -15.08836 -41.64544 1.000 52.58306  ? 116 ALA A N   1 
ATOM   598  C  CA  . ALA A 1 116 ? -3.33318  -15.03644 -43.10286 1.000 51.53457  ? 116 ALA A CA  1 
ATOM   599  C  C   . ALA A 1 116 ? -3.58734  -13.62100 -43.60245 1.000 56.82817  ? 116 ALA A C   1 
ATOM   600  O  O   . ALA A 1 116 ? -3.00665  -13.19802 -44.60920 1.000 57.09404  ? 116 ALA A O   1 
ATOM   601  C  CB  . ALA A 1 116 ? -4.37164  -16.00146 -43.67242 1.000 47.93936  ? 116 ALA A CB  1 
ATOM   602  N  N   . MET A 1 117 ? -4.45030  -12.87638 -42.90495 1.000 61.34277  ? 117 MET A N   1 
ATOM   603  C  CA  . MET A 1 117 ? -4.76309  -11.50612 -43.29874 1.000 58.55497  ? 117 MET A CA  1 
ATOM   604  C  C   . MET A 1 117 ? -3.50529  -10.65738 -43.41543 1.000 61.55372  ? 117 MET A C   1 
ATOM   605  O  O   . MET A 1 117 ? -3.38608  -9.82201  -44.31930 1.000 65.01828  ? 117 MET A O   1 
ATOM   606  C  CB  . MET A 1 117 ? -5.72363  -10.88677 -42.28266 1.000 61.64598  ? 117 MET A CB  1 
ATOM   607  C  CG  . MET A 1 117 ? -6.05421  -9.42654  -42.53712 1.000 82.78603  ? 117 MET A CG  1 
ATOM   608  S  SD  . MET A 1 117 ? -6.67305  -8.58749  -41.06614 1.000 74.33132  ? 117 MET A SD  1 
ATOM   609  C  CE  . MET A 1 117 ? -5.92706  -9.57302  -39.76835 1.000 76.12458  ? 117 MET A CE  1 
ATOM   610  N  N   . ASN A 1 118 ? -2.55038  -10.86652 -42.51291 1.000 65.01027  ? 118 ASN A N   1 
ATOM   611  C  CA  . ASN A 1 118 ? -1.35744  -10.04096 -42.42132 1.000 55.70101  ? 118 ASN A CA  1 
ATOM   612  C  C   . ASN A 1 118 ? -0.14774  -10.69926 -43.07091 1.000 62.71669  ? 118 ASN A C   1 
ATOM   613  O  O   . ASN A 1 118 ? 0.99016   -10.32203 -42.76935 1.000 60.56383  ? 118 ASN A O   1 
ATOM   614  C  CB  . ASN A 1 118 ? -1.07706  -9.71328  -40.95560 1.000 61.27641  ? 118 ASN A CB  1 
ATOM   615  C  CG  . ASN A 1 118 ? -1.93857  -8.57227  -40.44307 1.000 72.54172  ? 118 ASN A CG  1 
ATOM   616  O  OD1 . ASN A 1 118 ? -1.98136  -8.30242  -39.24492 1.000 78.62882  ? 118 ASN A OD1 1 
ATOM   617  N  ND2 . ASN A 1 118 ? -2.62401  -7.89090  -41.35468 1.000 73.30695  ? 118 ASN A ND2 1 
ATOM   618  N  N   . LYS A 1 119 ? -0.37810  -11.67515 -43.95450 1.000 63.02731  ? 119 LYS A N   1 
ATOM   619  C  CA  . LYS A 1 119 ? 0.68762   -12.36107 -44.68742 1.000 66.87760  ? 119 LYS A CA  1 
ATOM   620  C  C   . LYS A 1 119 ? 1.72670   -12.94225 -43.73214 1.000 65.78228  ? 119 LYS A C   1 
ATOM   621  O  O   . LYS A 1 119 ? 2.92518   -12.96594 -44.02019 1.000 61.98765  ? 119 LYS A O   1 
ATOM   622  C  CB  . LYS A 1 119 ? 1.34628   -11.42324 -45.70186 1.000 67.83559  ? 119 LYS A CB  1 
ATOM   623  C  CG  . LYS A 1 119 ? 0.38421   -10.80009 -46.70138 1.000 83.37325  ? 119 LYS A CG  1 
ATOM   624  C  CD  . LYS A 1 119 ? 0.81524   -9.38358  -47.06012 1.000 102.16035 ? 119 LYS A CD  1 
ATOM   625  C  CE  . LYS A 1 119 ? -0.37131  -8.43448  -47.12159 1.000 86.58433  ? 119 LYS A CE  1 
ATOM   626  N  NZ  . LYS A 1 119 ? -0.01294  -7.14499  -47.77555 1.000 85.54163  ? 119 LYS A NZ  1 
ATOM   627  N  N   . SER A 1 120 ? 1.26032   -13.41974 -42.57972 1.000 58.06955  ? 120 SER A N   1 
ATOM   628  C  CA  . SER A 1 120 ? 2.14196   -13.81096 -41.49007 1.000 49.48606  ? 120 SER A CA  1 
ATOM   629  C  C   . SER A 1 120 ? 2.14898   -15.30798 -41.21481 1.000 47.76418  ? 120 SER A C   1 
ATOM   630  O  O   . SER A 1 120 ? 2.83705   -15.74593 -40.28717 1.000 53.17008  ? 120 SER A O   1 
ATOM   631  C  CB  . SER A 1 120 ? 1.75846   -13.05538 -40.21307 1.000 51.42871  ? 120 SER A CB  1 
ATOM   632  O  OG  . SER A 1 120 ? 2.89197   -12.83337 -39.39411 1.000 69.17195  ? 120 SER A OG  1 
ATOM   633  N  N   . ASP A 1 121 ? 1.40500   -16.10287 -41.97804 1.000 45.78487  ? 121 ASP A N   1 
ATOM   634  C  CA  . ASP A 1 121 ? 1.46560   -17.54663 -41.82273 1.000 43.15211  ? 121 ASP A CA  1 
ATOM   635  C  C   . ASP A 1 121 ? 2.65181   -18.10032 -42.61027 1.000 49.14706  ? 121 ASP A C   1 
ATOM   636  O  O   . ASP A 1 121 ? 3.41920   -17.36168 -43.23376 1.000 48.89414  ? 121 ASP A O   1 
ATOM   637  C  CB  . ASP A 1 121 ? 0.15103   -18.18763 -42.26036 1.000 49.89335  ? 121 ASP A CB  1 
ATOM   638  C  CG  . ASP A 1 121 ? -0.28089  -17.74825 -43.64333 1.000 56.45300  ? 121 ASP A CG  1 
ATOM   639  O  OD1 . ASP A 1 121 ? 0.36349   -16.84218 -44.21275 1.000 58.10934  ? 121 ASP A OD1 1 
ATOM   640  O  OD2 . ASP A 1 121 ? -1.27028  -18.30820 -44.16046 1.000 71.94540  ? 121 ASP A OD2 1 
ATOM   641  N  N   . VAL A 1 122 ? 2.81220   -19.42003 -42.58400 1.000 48.50299  ? 122 VAL A N   1 
ATOM   642  C  CA  . VAL A 1 122 ? 3.94710   -20.08267 -43.21322 1.000 46.03919  ? 122 VAL A CA  1 
ATOM   643  C  C   . VAL A 1 122 ? 3.43246   -21.11691 -44.20357 1.000 48.92569  ? 122 VAL A C   1 
ATOM   644  O  O   . VAL A 1 122 ? 2.63403   -21.98962 -43.84280 1.000 50.90702  ? 122 VAL A O   1 
ATOM   645  C  CB  . VAL A 1 122 ? 4.87206   -20.73331 -42.17048 1.000 50.02629  ? 122 VAL A CB  1 
ATOM   646  C  CG1 . VAL A 1 122 ? 6.06965   -21.35828 -42.85413 1.000 45.62953  ? 122 VAL A CG1 1 
ATOM   647  C  CG2 . VAL A 1 122 ? 5.32310   -19.69779 -41.15905 1.000 43.59069  ? 122 VAL A CG2 1 
ATOM   648  N  N   . GLU A 1 123 ? 3.90072   -21.01569 -45.44910 1.000 61.79980  ? 123 GLU A N   1 
ATOM   649  C  CA  . GLU A 1 123 ? 3.55259   -21.96359 -46.49256 1.000 54.62466  ? 123 GLU A CA  1 
ATOM   650  C  C   . GLU A 1 123 ? 4.03751   -23.36585 -46.12103 1.000 53.74152  ? 123 GLU A C   1 
ATOM   651  O  O   . GLU A 1 123 ? 4.97370   -23.51952 -45.33234 1.000 56.72236  ? 123 GLU A O   1 
ATOM   652  C  CB  . GLU A 1 123 ? 4.16905   -21.53824 -47.83117 1.000 55.96080  ? 123 GLU A CB  1 
ATOM   653  C  CG  . GLU A 1 123 ? 5.68107   -21.19600 -47.82762 1.000 62.48212  ? 123 GLU A CG  1 
ATOM   654  C  CD  . GLU A 1 123 ? 6.07753   -19.93808 -47.04406 1.000 96.08115  ? 123 GLU A CD  1 
ATOM   655  O  OE1 . GLU A 1 123 ? 5.27295   -19.41552 -46.24322 1.000 65.20331  ? 123 GLU A OE1 1 
ATOM   656  O  OE2 . GLU A 1 123 ? 7.22578   -19.47675 -47.22273 1.000 95.40198  ? 123 GLU A OE2 1 
ATOM   657  N  N   . PRO A 1 124 ? 3.40719   -24.40496 -46.67287 1.000 51.53510  ? 124 PRO A N   1 
ATOM   658  C  CA  . PRO A 1 124 ? 3.88422   -25.77278 -46.42192 1.000 51.81638  ? 124 PRO A CA  1 
ATOM   659  C  C   . PRO A 1 124 ? 5.34139   -25.92835 -46.83178 1.000 52.30612  ? 124 PRO A C   1 
ATOM   660  O  O   . PRO A 1 124 ? 5.74767   -25.50979 -47.91776 1.000 57.57900  ? 124 PRO A O   1 
ATOM   661  C  CB  . PRO A 1 124 ? 2.95489   -26.63442 -47.28529 1.000 46.43883  ? 124 PRO A CB  1 
ATOM   662  C  CG  . PRO A 1 124 ? 1.71529   -25.82037 -47.42216 1.000 49.83665  ? 124 PRO A CG  1 
ATOM   663  C  CD  . PRO A 1 124 ? 2.18185   -24.39334 -47.49075 1.000 48.86311  ? 124 PRO A CD  1 
ATOM   664  N  N   . GLY A 1 125 ? 6.13348   -26.52801 -45.94243 1.000 50.20638  ? 125 GLY A N   1 
ATOM   665  C  CA  . GLY A 1 125 ? 7.56291   -26.63639 -46.14000 1.000 36.72123  ? 125 GLY A CA  1 
ATOM   666  C  C   . GLY A 1 125 ? 8.34104   -25.36068 -45.91515 1.000 54.78444  ? 125 GLY A C   1 
ATOM   667  O  O   . GLY A 1 125 ? 9.57700   -25.39457 -45.96501 1.000 48.14283  ? 125 GLY A O   1 
ATOM   668  N  N   . GLY A 1 126 ? 7.66919   -24.23636 -45.66117 1.000 49.43246  ? 126 GLY A N   1 
ATOM   669  C  CA  . GLY A 1 126 ? 8.35516   -22.97207 -45.51879 1.000 46.88122  ? 126 GLY A CA  1 
ATOM   670  C  C   . GLY A 1 126 ? 8.93833   -22.75937 -44.13550 1.000 49.02129  ? 126 GLY A C   1 
ATOM   671  O  O   . GLY A 1 126 ? 8.70916   -23.52418 -43.19894 1.000 51.24804  ? 126 GLY A O   1 
ATOM   672  N  N   . THR A 1 127 ? 9.70988   -21.68073 -44.01767 1.000 47.23941  ? 127 THR A N   1 
ATOM   673  C  CA  . THR A 1 127 ? 10.34955  -21.30485 -42.76507 1.000 47.54322  ? 127 THR A CA  1 
ATOM   674  C  C   . THR A 1 127 ? 10.27019  -19.79521 -42.60576 1.000 50.05002  ? 127 THR A C   1 
ATOM   675  O  O   . THR A 1 127 ? 10.62226  -19.05349 -43.52723 1.000 60.72506  ? 127 THR A O   1 
ATOM   676  C  CB  . THR A 1 127 ? 11.81154  -21.76584 -42.72438 1.000 49.24043  ? 127 THR A CB  1 
ATOM   677  O  OG1 . THR A 1 127 ? 11.86332  -23.19801 -42.72924 1.000 58.25495  ? 127 THR A OG1 1 
ATOM   678  C  CG2 . THR A 1 127 ? 12.50085  -21.24355 -41.47491 1.000 42.99603  ? 127 THR A CG2 1 
ATOM   679  N  N   . ARG A 1 128 ? 9.80715   -19.34571 -41.44136 1.000 48.98529  ? 128 ARG A N   1 
ATOM   680  C  CA  . ARG A 1 128 ? 9.65503   -17.92667 -41.15981 1.000 43.48354  ? 128 ARG A CA  1 
ATOM   681  C  C   . ARG A 1 128 ? 10.13787  -17.65099 -39.74503 1.000 47.29159  ? 128 ARG A C   1 
ATOM   682  O  O   . ARG A 1 128 ? 9.94695   -18.47489 -38.84645 1.000 53.67540  ? 128 ARG A O   1 
ATOM   683  C  CB  . ARG A 1 128 ? 8.19469   -17.48304 -41.32784 1.000 47.84660  ? 128 ARG A CB  1 
ATOM   684  C  CG  . ARG A 1 128 ? 7.88560   -16.08702 -40.81763 1.000 47.89631  ? 128 ARG A CG  1 
ATOM   685  C  CD  . ARG A 1 128 ? 6.41013   -15.76351 -40.97450 1.000 48.35459  ? 128 ARG A CD  1 
ATOM   686  N  NE  . ARG A 1 128 ? 6.17708   -14.33050 -41.10544 1.000 65.71060  ? 128 ARG A NE  1 
ATOM   687  C  CZ  . ARG A 1 128 ? 5.82574   -13.73080 -42.23460 1.000 62.11673  ? 128 ARG A CZ  1 
ATOM   688  N  NH1 . ARG A 1 128 ? 5.66573   -14.41168 -43.35774 1.000 55.89595  ? 128 ARG A NH1 1 
ATOM   689  N  NH2 . ARG A 1 128 ? 5.62991   -12.41528 -42.23694 1.000 62.35916  ? 128 ARG A NH2 1 
ATOM   690  N  N   . THR A 1 129 ? 10.76913  -16.49509 -39.55305 1.000 48.85492  ? 129 THR A N   1 
ATOM   691  C  CA  . THR A 1 129 ? 11.31760  -16.10404 -38.25941 1.000 53.45792  ? 129 THR A CA  1 
ATOM   692  C  C   . THR A 1 129 ? 10.35816  -15.13121 -37.58204 1.000 53.25718  ? 129 THR A C   1 
ATOM   693  O  O   . THR A 1 129 ? 10.25425  -13.96807 -37.98497 1.000 56.10159  ? 129 THR A O   1 
ATOM   694  C  CB  . THR A 1 129 ? 12.70132  -15.47879 -38.41988 1.000 45.15594  ? 129 THR A CB  1 
ATOM   695  O  OG1 . THR A 1 129 ? 13.60210  -16.44695 -38.97144 1.000 62.11087  ? 129 THR A OG1 1 
ATOM   696  C  CG2 . THR A 1 129 ? 13.23114  -15.01151 -37.07231 1.000 40.55554  ? 129 THR A CG2 1 
ATOM   697  N  N   . TYR A 1 130 ? 9.65756   -15.61013 -36.55836 1.000 47.96797  ? 130 TYR A N   1 
ATOM   698  C  CA  . TYR A 1 130 ? 8.85095   -14.73915 -35.71955 1.000 45.31979  ? 130 TYR A CA  1 
ATOM   699  C  C   . TYR A 1 130 ? 9.72154   -14.08820 -34.65277 1.000 43.87052  ? 130 TYR A C   1 
ATOM   700  O  O   . TYR A 1 130 ? 10.76364  -14.62076 -34.26114 1.000 53.85834  ? 130 TYR A O   1 
ATOM   701  C  CB  . TYR A 1 130 ? 7.72011   -15.52083 -35.05043 1.000 45.73733  ? 130 TYR A CB  1 
ATOM   702  C  CG  . TYR A 1 130 ? 6.69955   -16.09755 -36.00431 1.000 42.64348  ? 130 TYR A CG  1 
ATOM   703  C  CD1 . TYR A 1 130 ? 5.73995   -15.28888 -36.59789 1.000 48.51651  ? 130 TYR A CD1 1 
ATOM   704  C  CD2 . TYR A 1 130 ? 6.68690   -17.45315 -36.30006 1.000 45.36660  ? 130 TYR A CD2 1 
ATOM   705  C  CE1 . TYR A 1 130 ? 4.80146   -15.81351 -37.46542 1.000 43.07211  ? 130 TYR A CE1 1 
ATOM   706  C  CE2 . TYR A 1 130 ? 5.75259   -17.98706 -37.16655 1.000 45.35825  ? 130 TYR A CE2 1 
ATOM   707  C  CZ  . TYR A 1 130 ? 4.81184   -17.16317 -37.74498 1.000 40.67815  ? 130 TYR A CZ  1 
ATOM   708  O  OH  . TYR A 1 130 ? 3.87905   -17.69151 -38.60739 1.000 43.91104  ? 130 TYR A OH  1 
ATOM   709  N  N   . THR A 1 131 ? 9.28332   -12.92451 -34.17921 1.000 49.48628  ? 131 THR A N   1 
ATOM   710  C  CA  . THR A 1 131 ? 9.97397   -12.20893 -33.11333 1.000 45.37564  ? 131 THR A CA  1 
ATOM   711  C  C   . THR A 1 131 ? 8.96229   -11.80415 -32.05423 1.000 48.72959  ? 131 THR A C   1 
ATOM   712  O  O   . THR A 1 131 ? 8.02993   -11.04525 -32.33963 1.000 47.56870  ? 131 THR A O   1 
ATOM   713  C  CB  . THR A 1 131 ? 10.71014  -10.97630 -33.64637 1.000 44.52685  ? 131 THR A CB  1 
ATOM   714  O  OG1 . THR A 1 131 ? 11.73308  -11.38736 -34.56076 1.000 51.09417  ? 131 THR A OG1 1 
ATOM   715  C  CG2 . THR A 1 131 ? 11.34527  -10.20042 -32.50034 1.000 40.22278  ? 131 THR A CG2 1 
ATOM   716  N  N   . TRP A 1 132 ? 9.14199   -12.31779 -30.84178 1.000 44.91357  ? 132 TRP A N   1 
ATOM   717  C  CA  . TRP A 1 132 ? 8.35703   -11.91450 -29.68485 1.000 43.94609  ? 132 TRP A CA  1 
ATOM   718  C  C   . TRP A 1 132 ? 9.23768   -11.08489 -28.76480 1.000 49.17243  ? 132 TRP A C   1 
ATOM   719  O  O   . TRP A 1 132 ? 10.36311  -11.48598 -28.44897 1.000 52.94967  ? 132 TRP A O   1 
ATOM   720  C  CB  . TRP A 1 132 ? 7.80939   -13.12341 -28.92318 1.000 37.90076  ? 132 TRP A CB  1 
ATOM   721  C  CG  . TRP A 1 132 ? 6.98361   -14.06164 -29.74090 1.000 40.85385  ? 132 TRP A CG  1 
ATOM   722  C  CD1 . TRP A 1 132 ? 6.43759   -13.82518 -30.96846 1.000 39.88919  ? 132 TRP A CD1 1 
ATOM   723  C  CD2 . TRP A 1 132 ? 6.59723   -15.39143 -29.37840 1.000 40.33450  ? 132 TRP A CD2 1 
ATOM   724  N  NE1 . TRP A 1 132 ? 5.74077   -14.93004 -31.39603 1.000 42.88171  ? 132 TRP A NE1 1 
ATOM   725  C  CE2 . TRP A 1 132 ? 5.82319   -15.90489 -30.43665 1.000 37.30979  ? 132 TRP A CE2 1 
ATOM   726  C  CE3 . TRP A 1 132 ? 6.83393   -16.19868 -28.26113 1.000 40.94501  ? 132 TRP A CE3 1 
ATOM   727  C  CZ2 . TRP A 1 132 ? 5.28534   -17.18931 -30.41196 1.000 41.35418  ? 132 TRP A CZ2 1 
ATOM   728  C  CZ3 . TRP A 1 132 ? 6.29922   -17.47092 -28.23711 1.000 39.21264  ? 132 TRP A CZ3 1 
ATOM   729  C  CH2 . TRP A 1 132 ? 5.53311   -17.95469 -29.30549 1.000 45.15329  ? 132 TRP A CH2 1 
ATOM   730  N  N   . ARG A 1 133 ? 8.72899   -9.93516  -28.33902 1.000 49.03686  ? 133 ARG A N   1 
ATOM   731  C  CA  . ARG A 1 133 ? 9.43391   -9.07947  -27.40128 1.000 42.40998  ? 133 ARG A CA  1 
ATOM   732  C  C   . ARG A 1 133 ? 8.63927   -8.97522  -26.10824 1.000 45.38458  ? 133 ARG A C   1 
ATOM   733  O  O   . ARG A 1 133 ? 7.41446   -9.12942  -26.09612 1.000 49.61288  ? 133 ARG A O   1 
ATOM   734  C  CB  . ARG A 1 133 ? 9.67641   -7.68322  -27.98904 1.000 45.57934  ? 133 ARG A CB  1 
ATOM   735  C  CG  . ARG A 1 133 ? 10.15887  -7.70203  -29.43102 1.000 55.79132  ? 133 ARG A CG  1 
ATOM   736  C  CD  . ARG A 1 133 ? 11.06337  -6.52108  -29.74110 1.000 51.98590  ? 133 ARG A CD  1 
ATOM   737  N  NE  . ARG A 1 133 ? 11.43013  -6.48424  -31.15198 1.000 76.42168  ? 133 ARG A NE  1 
ATOM   738  C  CZ  . ARG A 1 133 ? 12.67590  -6.53626  -31.60498 1.000 90.25835  ? 133 ARG A CZ  1 
ATOM   739  N  NH1 . ARG A 1 133 ? 13.70852  -6.62513  -30.78179 1.000 83.81725  ? 133 ARG A NH1 1 
ATOM   740  N  NH2 . ARG A 1 133 ? 12.89114  -6.50265  -32.91721 1.000 79.66014  ? 133 ARG A NH2 1 
ATOM   741  N  N   . THR A 1 134 ? 9.35607   -8.73988  -25.01398 1.000 47.73112  ? 134 THR A N   1 
ATOM   742  C  CA  . THR A 1 134 ? 8.75433   -8.48319  -23.71630 1.000 47.47482  ? 134 THR A CA  1 
ATOM   743  C  C   . THR A 1 134 ? 9.35133   -7.20610  -23.14425 1.000 48.37240  ? 134 THR A C   1 
ATOM   744  O  O   . THR A 1 134 ? 10.42908  -6.76448  -23.54995 1.000 52.33172  ? 134 THR A O   1 
ATOM   745  C  CB  . THR A 1 134 ? 8.97035   -9.64912  -22.74056 1.000 47.36569  ? 134 THR A CB  1 
ATOM   746  O  OG1 . THR A 1 134 ? 10.35855  -9.73604  -22.39765 1.000 46.13166  ? 134 THR A OG1 1 
ATOM   747  C  CG2 . THR A 1 134 ? 8.51597   -10.96323 -23.36217 1.000 40.27677  ? 134 THR A CG2 1 
ATOM   748  N  N   . HIS A 1 135 ? 8.63804   -6.61122  -22.19266 1.000 47.21038  ? 135 HIS A N   1 
ATOM   749  C  CA  . HIS A 1 135 ? 9.06245   -5.35205  -21.60361 1.000 44.22544  ? 135 HIS A CA  1 
ATOM   750  C  C   . HIS A 1 135 ? 8.70892   -5.33015  -20.12597 1.000 45.32462  ? 135 HIS A C   1 
ATOM   751  O  O   . HIS A 1 135 ? 7.71747   -5.92675  -19.69704 1.000 49.92954  ? 135 HIS A O   1 
ATOM   752  C  CB  . HIS A 1 135 ? 8.41595   -4.15493  -22.30919 1.000 48.52580  ? 135 HIS A CB  1 
ATOM   753  C  CG  . HIS A 1 135 ? 6.92857   -4.10030  -22.15841 1.000 45.83436  ? 135 HIS A CG  1 
ATOM   754  N  ND1 . HIS A 1 135 ? 6.06850   -4.72565  -23.03481 1.000 48.24379  ? 135 HIS A ND1 1 
ATOM   755  C  CD2 . HIS A 1 135 ? 6.14809   -3.49845  -21.23017 1.000 49.14583  ? 135 HIS A CD2 1 
ATOM   756  C  CE1 . HIS A 1 135 ? 4.82202   -4.50991  -22.65441 1.000 50.64137  ? 135 HIS A CE1 1 
ATOM   757  N  NE2 . HIS A 1 135 ? 4.84259   -3.76769  -21.56197 1.000 51.75864  ? 135 HIS A NE2 1 
ATOM   758  N  N   . LYS A 1 136 ? 9.53451   -4.63244  -19.35492 1.000 45.44346  ? 136 LYS A N   1 
ATOM   759  C  CA  . LYS A 1 136 ? 9.28627   -4.43793  -17.93865 1.000 48.15935  ? 136 LYS A CA  1 
ATOM   760  C  C   . LYS A 1 136 ? 8.25845   -3.32743  -17.73473 1.000 50.66701  ? 136 LYS A C   1 
ATOM   761  O  O   . LYS A 1 136 ? 8.11092   -2.44598  -18.58551 1.000 54.85821  ? 136 LYS A O   1 
ATOM   762  C  CB  . LYS A 1 136 ? 10.58199  -4.07849  -17.21691 1.000 46.77754  ? 136 LYS A CB  1 
ATOM   763  C  CG  . LYS A 1 136 ? 11.66380  -5.14227  -17.31121 1.000 54.52770  ? 136 LYS A CG  1 
ATOM   764  C  CD  . LYS A 1 136 ? 13.05182  -4.51975  -17.29588 1.000 63.92460  ? 136 LYS A CD  1 
ATOM   765  C  CE  . LYS A 1 136 ? 14.11342  -5.53728  -16.90236 1.000 66.36488  ? 136 LYS A CE  1 
ATOM   766  N  NZ  . LYS A 1 136 ? 15.49002  -5.06691  -17.22784 1.000 73.34517  ? 136 LYS A NZ  1 
ATOM   767  N  N   . PRO A 1 137 ? 7.52464   -3.35360  -16.62626 1.000 49.88252  ? 137 PRO A N   1 
ATOM   768  C  CA  . PRO A 1 137 ? 6.64732   -2.22601  -16.30479 1.000 49.20171  ? 137 PRO A CA  1 
ATOM   769  C  C   . PRO A 1 137 ? 7.46260   -0.98792  -15.96856 1.000 48.53775  ? 137 PRO A C   1 
ATOM   770  O  O   . PRO A 1 137 ? 8.62380   -1.06258  -15.55995 1.000 53.54105  ? 137 PRO A O   1 
ATOM   771  C  CB  . PRO A 1 137 ? 5.85626   -2.72316  -15.09095 1.000 48.26153  ? 137 PRO A CB  1 
ATOM   772  C  CG  . PRO A 1 137 ? 6.74912   -3.74119  -14.46562 1.000 50.04594  ? 137 PRO A CG  1 
ATOM   773  C  CD  . PRO A 1 137 ? 7.44204   -4.42032  -15.61387 1.000 47.89869  ? 137 PRO A CD  1 
ATOM   774  N  N   . GLY A 1 138 ? 6.83864   0.16665   -16.15711 1.000 47.79810  ? 138 GLY A N   1 
ATOM   775  C  CA  . GLY A 1 138 ? 7.53051   1.41781   -15.91137 1.000 53.46446  ? 138 GLY A CA  1 
ATOM   776  C  C   . GLY A 1 138 ? 6.61219   2.59549   -16.14094 1.000 55.05637  ? 138 GLY A C   1 
ATOM   777  O  O   . GLY A 1 138 ? 5.50158   2.46140   -16.66645 1.000 52.41640  ? 138 GLY A O   1 
ATOM   778  N  N   . ARG A 1 139 ? 7.10571   3.76316   -15.73885 1.000 65.32270  ? 139 ARG A N   1 
ATOM   779  C  CA  . ARG A 1 139 ? 6.34845   5.00021   -15.85393 1.000 58.21571  ? 139 ARG A CA  1 
ATOM   780  C  C   . ARG A 1 139 ? 6.44350   5.54516   -17.27277 1.000 51.30728  ? 139 ARG A C   1 
ATOM   781  O  O   . ARG A 1 139 ? 7.53276   5.61165   -17.85058 1.000 51.68549  ? 139 ARG A O   1 
ATOM   782  C  CB  . ARG A 1 139 ? 6.87008   6.03004   -14.85262 1.000 57.49110  ? 139 ARG A CB  1 
ATOM   783  C  CG  . ARG A 1 139 ? 5.89569   7.15005   -14.54097 1.000 66.12022  ? 139 ARG A CG  1 
ATOM   784  C  CD  . ARG A 1 139 ? 4.65447   6.62563   -13.83875 1.000 78.46907  ? 139 ARG A CD  1 
ATOM   785  N  NE  . ARG A 1 139 ? 4.86195   6.45634   -12.40548 1.000 74.34705  ? 139 ARG A NE  1 
ATOM   786  C  CZ  . ARG A 1 139 ? 3.93942   6.00799   -11.56494 1.000 77.11437  ? 139 ARG A CZ  1 
ATOM   787  N  NH1 . ARG A 1 139 ? 2.72092   5.69840   -11.97725 1.000 63.12299  ? 139 ARG A NH1 1 
ATOM   788  N  NH2 . ARG A 1 139 ? 4.24595   5.86926   -10.27805 1.000 80.01727  ? 139 ARG A NH2 1 
ATOM   789  N  N   . ARG A 1 140 ? 5.30040   5.92928   -17.83345 1.000 61.52895  ? 140 ARG A N   1 
ATOM   790  C  CA  . ARG A 1 140 ? 5.27001   6.52297   -19.15921 1.000 58.27896  ? 140 ARG A CA  1 
ATOM   791  C  C   . ARG A 1 140 ? 5.63670   8.00349   -19.08789 1.000 63.14240  ? 140 ARG A C   1 
ATOM   792  O  O   . ARG A 1 140 ? 5.76232   8.59257   -18.01089 1.000 66.19453  ? 140 ARG A O   1 
ATOM   793  C  CB  . ARG A 1 140 ? 3.89169   6.35247   -19.79588 1.000 50.96974  ? 140 ARG A CB  1 
ATOM   794  C  CG  . ARG A 1 140 ? 3.59411   4.95132   -20.29341 1.000 49.44682  ? 140 ARG A CG  1 
ATOM   795  C  CD  . ARG A 1 140 ? 2.38150   4.95125   -21.20665 1.000 43.56563  ? 140 ARG A CD  1 
ATOM   796  N  NE  . ARG A 1 140 ? 1.90749   3.60271   -21.49154 1.000 49.57348  ? 140 ARG A NE  1 
ATOM   797  C  CZ  . ARG A 1 140 ? 0.91017   3.01004   -20.84967 1.000 49.98496  ? 140 ARG A CZ  1 
ATOM   798  N  NH1 . ARG A 1 140 ? 0.26482   3.61580   -19.86619 1.000 43.88280  ? 140 ARG A NH1 1 
ATOM   799  N  NH2 . ARG A 1 140 ? 0.55261   1.77811   -21.20200 1.000 48.45461  ? 140 ARG A NH2 1 
ATOM   800  N  N   . ASP A 1 141 ? 5.80495   8.60980   -20.26590 1.000 70.14146  ? 141 ASP A N   1 
ATOM   801  C  CA  . ASP A 1 141 ? 6.14020   10.02877  -20.32138 1.000 67.51767  ? 141 ASP A CA  1 
ATOM   802  C  C   . ASP A 1 141 ? 5.01659   10.89372  -19.76533 1.000 74.38207  ? 141 ASP A C   1 
ATOM   803  O  O   . ASP A 1 141 ? 5.28084   11.93482  -19.15319 1.000 68.34182  ? 141 ASP A O   1 
ATOM   804  C  CB  . ASP A 1 141 ? 6.46512   10.43733  -21.75810 1.000 71.36361  ? 141 ASP A CB  1 
ATOM   805  C  CG  . ASP A 1 141 ? 7.95658   10.49338  -22.02313 1.000 88.18338  ? 141 ASP A CG  1 
ATOM   806  O  OD1 . ASP A 1 141 ? 8.35217   10.53219  -23.20696 1.000 94.81904  ? 141 ASP A OD1 1 
ATOM   807  O  OD2 . ASP A 1 141 ? 8.73424   10.49611  -21.04574 1.000 98.39410  ? 141 ASP A OD2 1 
ATOM   808  N  N   . ASP A 1 142 ? 3.76385   10.48347  -19.95931 1.000 68.49118  ? 142 ASP A N   1 
ATOM   809  C  CA  . ASP A 1 142 ? 2.63000   11.22934  -19.42906 1.000 60.63882  ? 142 ASP A CA  1 
ATOM   810  C  C   . ASP A 1 142 ? 2.38568   10.97118  -17.94782 1.000 69.63858  ? 142 ASP A C   1 
ATOM   811  O  O   . ASP A 1 142 ? 1.43059   11.52264  -17.39167 1.000 71.81164  ? 142 ASP A O   1 
ATOM   812  C  CB  . ASP A 1 142 ? 1.36105   10.90756  -20.22842 1.000 55.93069  ? 142 ASP A CB  1 
ATOM   813  C  CG  . ASP A 1 142 ? 0.97759   9.43637   -20.16731 1.000 65.18479  ? 142 ASP A CG  1 
ATOM   814  O  OD1 . ASP A 1 142 ? 1.65728   8.65528   -19.46890 1.000 68.40040  ? 142 ASP A OD1 1 
ATOM   815  O  OD2 . ASP A 1 142 ? -0.01890  9.05988   -20.82007 1.000 66.42187  ? 142 ASP A OD2 1 
ATOM   816  N  N   . GLY A 1 143 ? 3.21048   10.14897  -17.30200 1.000 64.82049  ? 143 GLY A N   1 
ATOM   817  C  CA  . GLY A 1 143 ? 3.04484   9.84273   -15.89820 1.000 60.22597  ? 143 GLY A CA  1 
ATOM   818  C  C   . GLY A 1 143 ? 2.19895   8.62629   -15.59643 1.000 55.05439  ? 143 GLY A C   1 
ATOM   819  O  O   . GLY A 1 143 ? 1.98984   8.31659   -14.41674 1.000 61.67135  ? 143 GLY A O   1 
ATOM   820  N  N   . THR A 1 144 ? 1.70216   7.93157   -16.61311 1.000 56.16707  ? 144 THR A N   1 
ATOM   821  C  CA  . THR A 1 144 ? 0.91044   6.73170   -16.40318 1.000 50.32886  ? 144 THR A CA  1 
ATOM   822  C  C   . THR A 1 144 ? 1.82029   5.51230   -16.27087 1.000 55.45766  ? 144 THR A C   1 
ATOM   823  O  O   . THR A 1 144 ? 3.00853   5.54750   -16.59825 1.000 56.67301  ? 144 THR A O   1 
ATOM   824  C  CB  . THR A 1 144 ? -0.08792  6.54094   -17.54505 1.000 56.49364  ? 144 THR A CB  1 
ATOM   825  O  OG1 . THR A 1 144 ? 0.62042   6.38742   -18.78117 1.000 58.71631  ? 144 THR A OG1 1 
ATOM   826  C  CG2 . THR A 1 144 ? -1.01590  7.74494   -17.64228 1.000 54.07329  ? 144 THR A CG2 1 
ATOM   827  N  N   . TRP A 1 145 ? 1.24600   4.42114   -15.77607 1.000 54.02070  ? 145 TRP A N   1 
ATOM   828  C  CA  . TRP A 1 145 ? 1.98648   3.19174   -15.52921 1.000 51.43697  ? 145 TRP A CA  1 
ATOM   829  C  C   . TRP A 1 145 ? 1.75254   2.22176   -16.67936 1.000 47.60687  ? 145 TRP A C   1 
ATOM   830  O  O   . TRP A 1 145 ? 0.62327   1.76895   -16.89495 1.000 50.85138  ? 145 TRP A O   1 
ATOM   831  C  CB  . TRP A 1 145 ? 1.56894   2.55908   -14.20273 1.000 57.74910  ? 145 TRP A CB  1 
ATOM   832  C  CG  . TRP A 1 145 ? 2.48011   1.45843   -13.76362 1.000 55.32565  ? 145 TRP A CG  1 
ATOM   833  C  CD1 . TRP A 1 145 ? 2.19923   0.12332   -13.73157 1.000 50.00146  ? 145 TRP A CD1 1 
ATOM   834  C  CD2 . TRP A 1 145 ? 3.82695   1.59676   -13.29858 1.000 54.56605  ? 145 TRP A CD2 1 
ATOM   835  N  NE1 . TRP A 1 145 ? 3.28776   -0.57807  -13.27216 1.000 49.23557  ? 145 TRP A NE1 1 
ATOM   836  C  CE2 . TRP A 1 145 ? 4.30021   0.30401   -12.99931 1.000 58.88506  ? 145 TRP A CE2 1 
ATOM   837  C  CE3 . TRP A 1 145 ? 4.67845   2.68865   -13.10473 1.000 59.05280  ? 145 TRP A CE3 1 
ATOM   838  C  CZ2 . TRP A 1 145 ? 5.58669   0.07386   -12.51692 1.000 62.28343  ? 145 TRP A CZ2 1 
ATOM   839  C  CZ3 . TRP A 1 145 ? 5.95507   2.45778   -12.62634 1.000 59.53586  ? 145 TRP A CZ3 1 
ATOM   840  C  CH2 . TRP A 1 145 ? 6.39661   1.16130   -12.33727 1.000 46.10298  ? 145 TRP A CH2 1 
ATOM   841  N  N   . ARG A 1 146 ? 2.81373   1.90778   -17.40925 1.000 45.70714  ? 146 ARG A N   1 
ATOM   842  C  CA  . ARG A 1 146 ? 2.72084   0.91794   -18.47407 1.000 47.77382  ? 146 ARG A CA  1 
ATOM   843  C  C   . ARG A 1 146 ? 2.88388   -0.48122  -17.89128 1.000 48.12309  ? 146 ARG A C   1 
ATOM   844  O  O   . ARG A 1 146 ? 3.86034   -0.73932  -17.18102 1.000 47.80474  ? 146 ARG A O   1 
ATOM   845  C  CB  . ARG A 1 146 ? 3.78343   1.16863   -19.53881 1.000 45.85404  ? 146 ARG A CB  1 
ATOM   846  C  CG  . ARG A 1 146 ? 3.80023   0.13588   -20.65229 1.000 43.12623  ? 146 ARG A CG  1 
ATOM   847  C  CD  . ARG A 1 146 ? 5.10303   0.19457   -21.43027 1.000 47.71095  ? 146 ARG A CD  1 
ATOM   848  N  NE  . ARG A 1 146 ? 5.03707   -0.55822  -22.67732 1.000 54.06761  ? 146 ARG A NE  1 
ATOM   849  C  CZ  . ARG A 1 146 ? 6.07951   -0.79712  -23.46133 1.000 51.09169  ? 146 ARG A CZ  1 
ATOM   850  N  NH1 . ARG A 1 146 ? 7.28583   -0.34313  -23.16383 1.000 56.90062  ? 146 ARG A NH1 1 
ATOM   851  N  NH2 . ARG A 1 146 ? 5.90778   -1.51017  -24.57100 1.000 52.66445  ? 146 ARG A NH2 1 
ATOM   852  N  N   . PRO A 1 147 ? 1.95762   -1.39784  -18.15693 1.000 49.14224  ? 147 PRO A N   1 
ATOM   853  C  CA  . PRO A 1 147 ? 2.09264   -2.75389  -17.61805 1.000 43.22020  ? 147 PRO A CA  1 
ATOM   854  C  C   . PRO A 1 147 ? 3.23092   -3.50602  -18.28500 1.000 45.74012  ? 147 PRO A C   1 
ATOM   855  O  O   . PRO A 1 147 ? 3.61470   -3.22408  -19.42275 1.000 55.45973  ? 147 PRO A O   1 
ATOM   856  C  CB  . PRO A 1 147 ? 0.74022   -3.40478  -17.93936 1.000 44.57642  ? 147 PRO A CB  1 
ATOM   857  C  CG  . PRO A 1 147 ? -0.17210  -2.27155  -18.31422 1.000 49.01382  ? 147 PRO A CG  1 
ATOM   858  C  CD  . PRO A 1 147 ? 0.71225   -1.23305  -18.92039 1.000 49.70914  ? 147 PRO A CD  1 
ATOM   859  N  N   . GLY A 1 148 ? 3.77365   -4.47675  -17.55503 1.000 48.95719  ? 148 GLY A N   1 
ATOM   860  C  CA  . GLY A 1 148 ? 4.78887   -5.34965  -18.09709 1.000 44.39951  ? 148 GLY A CA  1 
ATOM   861  C  C   . GLY A 1 148 ? 4.18650   -6.50090  -18.87686 1.000 46.64131  ? 148 GLY A C   1 
ATOM   862  O  O   . GLY A 1 148 ? 2.97083   -6.66391  -18.97874 1.000 52.10991  ? 148 GLY A O   1 
ATOM   863  N  N   . SER A 1 149 ? 5.07064   -7.31951  -19.44128 1.000 48.02207  ? 149 SER A N   1 
ATOM   864  C  CA  . SER A 1 149 ? 4.65386   -8.48243  -20.21163 1.000 42.21504  ? 149 SER A CA  1 
ATOM   865  C  C   . SER A 1 149 ? 4.46429   -9.72905  -19.35864 1.000 40.06964  ? 149 SER A C   1 
ATOM   866  O  O   . SER A 1 149 ? 3.98543   -10.74391 -19.87654 1.000 44.23278  ? 149 SER A O   1 
ATOM   867  C  CB  . SER A 1 149 ? 5.67644   -8.78018  -21.31414 1.000 42.46290  ? 149 SER A CB  1 
ATOM   868  O  OG  . SER A 1 149 ? 5.94803   -7.62594  -22.08742 1.000 48.19533  ? 149 SER A OG  1 
ATOM   869  N  N   . ALA A 1 150 ? 4.81722   -9.67455  -18.07535 1.000 40.24104  ? 150 ALA A N   1 
ATOM   870  C  CA  . ALA A 1 150 ? 4.82173   -10.86893 -17.24080 1.000 43.74070  ? 150 ALA A CA  1 
ATOM   871  C  C   . ALA A 1 150 ? 3.43162   -11.48482 -17.14579 1.000 45.68435  ? 150 ALA A C   1 
ATOM   872  O  O   . ALA A 1 150 ? 2.42271   -10.77940 -17.05936 1.000 49.80689  ? 150 ALA A O   1 
ATOM   873  C  CB  . ALA A 1 150 ? 5.34050   -10.53365 -15.84244 1.000 41.37649  ? 150 ALA A CB  1 
ATOM   874  N  N   . GLY A 1 151 ? 3.38635   -12.80748 -17.16323 1.000 43.59529  ? 151 GLY A N   1 
ATOM   875  C  CA  . GLY A 1 151 ? 2.13201   -13.51685 -17.02729 1.000 44.26602  ? 151 GLY A CA  1 
ATOM   876  C  C   . GLY A 1 151 ? 2.22773   -14.91421 -17.60026 1.000 42.69321  ? 151 GLY A C   1 
ATOM   877  O  O   . GLY A 1 151 ? 3.25412   -15.32845 -18.14056 1.000 42.67805  ? 151 GLY A O   1 
ATOM   878  N  N   . TYR A 1 152 ? 1.12124   -15.63819 -17.45948 1.000 41.61515  ? 152 TYR A N   1 
ATOM   879  C  CA  . TYR A 1 152 ? 0.97150   -16.98111 -18.01276 1.000 44.08802  ? 152 TYR A CA  1 
ATOM   880  C  C   . TYR A 1 152 ? 0.22828   -16.84728 -19.33618 1.000 45.48148  ? 152 TYR A C   1 
ATOM   881  O  O   . TYR A 1 152 ? -0.99579  -16.69680 -19.36074 1.000 39.68586  ? 152 TYR A O   1 
ATOM   882  C  CB  . TYR A 1 152 ? 0.22914   -17.89159 -17.04041 1.000 40.27586  ? 152 TYR A CB  1 
ATOM   883  C  CG  . TYR A 1 152 ? 1.01667   -18.24088 -15.79886 1.000 43.10803  ? 152 TYR A CG  1 
ATOM   884  C  CD1 . TYR A 1 152 ? 1.98125   -19.24097 -15.82280 1.000 42.14549  ? 152 TYR A CD1 1 
ATOM   885  C  CD2 . TYR A 1 152 ? 0.80179   -17.56587 -14.60411 1.000 41.43745  ? 152 TYR A CD2 1 
ATOM   886  C  CE1 . TYR A 1 152 ? 2.70561   -19.56291 -14.68865 1.000 47.38414  ? 152 TYR A CE1 1 
ATOM   887  C  CE2 . TYR A 1 152 ? 1.51908   -17.88249 -13.46414 1.000 45.15096  ? 152 TYR A CE2 1 
ATOM   888  C  CZ  . TYR A 1 152 ? 2.47024   -18.87981 -13.51199 1.000 48.59946  ? 152 TYR A CZ  1 
ATOM   889  O  OH  . TYR A 1 152 ? 3.18648   -19.19402 -12.37956 1.000 42.68315  ? 152 TYR A OH  1 
ATOM   890  N  N   . TRP A 1 153 ? 0.97156   -16.89635 -20.43576 1.000 40.59486  ? 153 TRP A N   1 
ATOM   891  C  CA  . TRP A 1 153 ? 0.42204   -16.72991 -21.77016 1.000 37.98576  ? 153 TRP A CA  1 
ATOM   892  C  C   . TRP A 1 153 ? 0.47359   -18.05762 -22.52100 1.000 45.69434  ? 153 TRP A C   1 
ATOM   893  O  O   . TRP A 1 153 ? 0.78300   -19.11003 -21.94883 1.000 42.68530  ? 153 TRP A O   1 
ATOM   894  C  CB  . TRP A 1 153 ? 1.17803   -15.62527 -22.50749 1.000 39.59543  ? 153 TRP A CB  1 
ATOM   895  C  CG  . TRP A 1 153 ? 1.23028   -14.34090 -21.74179 1.000 45.82979  ? 153 TRP A CG  1 
ATOM   896  C  CD1 . TRP A 1 153 ? 2.29469   -13.84048 -21.05047 1.000 34.49327  ? 153 TRP A CD1 1 
ATOM   897  C  CD2 . TRP A 1 153 ? 0.16695   -13.39439 -21.58289 1.000 43.62808  ? 153 TRP A CD2 1 
ATOM   898  N  NE1 . TRP A 1 153 ? 1.96124   -12.63908 -20.47359 1.000 39.78206  ? 153 TRP A NE1 1 
ATOM   899  C  CE2 . TRP A 1 153 ? 0.66023   -12.34285 -20.78543 1.000 41.68801  ? 153 TRP A CE2 1 
ATOM   900  C  CE3 . TRP A 1 153 ? -1.15454  -13.33423 -22.03797 1.000 45.19765  ? 153 TRP A CE3 1 
ATOM   901  C  CZ2 . TRP A 1 153 ? -0.11998  -11.24359 -20.43458 1.000 37.00530  ? 153 TRP A CZ2 1 
ATOM   902  C  CZ3 . TRP A 1 153 ? -1.92691  -12.24153 -21.68945 1.000 36.98394  ? 153 TRP A CZ3 1 
ATOM   903  C  CH2 . TRP A 1 153 ? -1.40730  -11.21131 -20.89709 1.000 43.19734  ? 153 TRP A CH2 1 
ATOM   904  N  N   . HIS A 1 154 ? 0.16737   -18.00834 -23.81525 1.000 41.06208  ? 154 HIS A N   1 
ATOM   905  C  CA  . HIS A 1 154 ? 0.15988   -19.21634 -24.62666 1.000 39.83128  ? 154 HIS A CA  1 
ATOM   906  C  C   . HIS A 1 154 ? 0.28892   -18.83995 -26.09445 1.000 41.85144  ? 154 HIS A C   1 
ATOM   907  O  O   . HIS A 1 154 ? 0.08217   -17.68749 -26.48313 1.000 44.24638  ? 154 HIS A O   1 
ATOM   908  C  CB  . HIS A 1 154 ? -1.10928  -20.04375 -24.39165 1.000 36.03788  ? 154 HIS A CB  1 
ATOM   909  C  CG  . HIS A 1 154 ? -2.36728  -19.36310 -24.83311 1.000 44.41937  ? 154 HIS A CG  1 
ATOM   910  N  ND1 . HIS A 1 154 ? -2.94866  -18.33756 -24.11896 1.000 43.65196  ? 154 HIS A ND1 1 
ATOM   911  C  CD2 . HIS A 1 154 ? -3.15708  -19.56285 -25.91487 1.000 46.06355  ? 154 HIS A CD2 1 
ATOM   912  C  CE1 . HIS A 1 154 ? -4.04183  -17.93422 -24.74159 1.000 40.95543  ? 154 HIS A CE1 1 
ATOM   913  N  NE2 . HIS A 1 154 ? -4.19121  -18.66172 -25.83394 1.000 41.66343  ? 154 HIS A NE2 1 
ATOM   914  N  N   . TYR A 1 155 ? 0.64137   -19.83634 -26.90272 1.000 39.31694  ? 155 TYR A N   1 
ATOM   915  C  CA  . TYR A 1 155 ? 0.74600   -19.68691 -28.34478 1.000 38.21610  ? 155 TYR A CA  1 
ATOM   916  C  C   . TYR A 1 155 ? -0.05256  -20.79187 -29.01863 1.000 36.42201  ? 155 TYR A C   1 
ATOM   917  O  O   . TYR A 1 155 ? -0.21896  -21.88144 -28.46471 1.000 48.42778  ? 155 TYR A O   1 
ATOM   918  C  CB  . TYR A 1 155 ? 2.21175   -19.72755 -28.81549 1.000 37.72079  ? 155 TYR A CB  1 
ATOM   919  C  CG  . TYR A 1 155 ? 2.93310   -21.02819 -28.51878 1.000 43.36760  ? 155 TYR A CG  1 
ATOM   920  C  CD1 . TYR A 1 155 ? 2.83085   -22.11825 -29.37518 1.000 34.82834  ? 155 TYR A CD1 1 
ATOM   921  C  CD2 . TYR A 1 155 ? 3.72060   -21.16335 -27.38341 1.000 41.86796  ? 155 TYR A CD2 1 
ATOM   922  C  CE1 . TYR A 1 155 ? 3.48870   -23.30307 -29.10676 1.000 35.96575  ? 155 TYR A CE1 1 
ATOM   923  C  CE2 . TYR A 1 155 ? 4.38196   -22.34569 -27.10630 1.000 37.81285  ? 155 TYR A CE2 1 
ATOM   924  C  CZ  . TYR A 1 155 ? 4.26303   -23.41190 -27.97229 1.000 40.40970  ? 155 TYR A CZ  1 
ATOM   925  O  OH  . TYR A 1 155 ? 4.91857   -24.59233 -27.70128 1.000 49.22228  ? 155 TYR A OH  1 
ATOM   926  N  N   . HIS A 1 156 ? -0.54315  -20.50662 -30.22113 1.000 35.26196  ? 156 HIS A N   1 
ATOM   927  C  CA  . HIS A 1 156 ? -1.31991  -21.48863 -30.96502 1.000 36.15208  ? 156 HIS A CA  1 
ATOM   928  C  C   . HIS A 1 156 ? -1.32349  -21.10858 -32.43804 1.000 40.88893  ? 156 HIS A C   1 
ATOM   929  O  O   . HIS A 1 156 ? -0.94776  -19.99686 -32.81833 1.000 41.73171  ? 156 HIS A O   1 
ATOM   930  C  CB  . HIS A 1 156 ? -2.75087  -21.59630 -30.42876 1.000 35.60741  ? 156 HIS A CB  1 
ATOM   931  C  CG  . HIS A 1 156 ? -3.52450  -20.31838 -30.51260 1.000 43.54355  ? 156 HIS A CG  1 
ATOM   932  N  ND1 . HIS A 1 156 ? -4.16438  -19.91062 -31.66325 1.000 43.57645  ? 156 HIS A ND1 1 
ATOM   933  C  CD2 . HIS A 1 156 ? -3.76056  -19.35646 -29.58961 1.000 38.94404  ? 156 HIS A CD2 1 
ATOM   934  C  CE1 . HIS A 1 156 ? -4.76283  -18.75355 -31.44523 1.000 45.57465  ? 156 HIS A CE1 1 
ATOM   935  N  NE2 . HIS A 1 156 ? -4.53297  -18.39531 -30.19489 1.000 52.52161  ? 156 HIS A NE2 1 
ATOM   936  N  N   . ASP A 1 157 ? -1.75841  -22.05685 -33.26299 1.000 40.93768  ? 157 ASP A N   1 
ATOM   937  C  CA  . ASP A 1 157 ? -1.88476  -21.82090 -34.69273 1.000 41.63786  ? 157 ASP A CA  1 
ATOM   938  C  C   . ASP A 1 157 ? -3.10715  -20.95729 -34.98621 1.000 48.06204  ? 157 ASP A C   1 
ATOM   939  O  O   . ASP A 1 157 ? -4.09415  -20.96488 -34.24515 1.000 47.38861  ? 157 ASP A O   1 
ATOM   940  C  CB  . ASP A 1 157 ? -1.99318  -23.14840 -35.43952 1.000 39.00353  ? 157 ASP A CB  1 
ATOM   941  C  CG  . ASP A 1 157 ? -2.53506  -22.98133 -36.83945 1.000 51.08010  ? 157 ASP A CG  1 
ATOM   942  O  OD1 . ASP A 1 157 ? -1.75551  -22.60979 -37.74299 1.000 49.84976  ? 157 ASP A OD1 1 
ATOM   943  O  OD2 . ASP A 1 157 ? -3.75327  -23.17847 -37.02349 1.000 50.74754  ? 157 ASP A OD2 1 
ATOM   944  N  N   . HIS A 1 158 ? -3.04209  -20.21528 -36.09542 1.000 48.72488  ? 158 HIS A N   1 
ATOM   945  C  CA  . HIS A 1 158 ? -4.09634  -19.27241 -36.44173 1.000 52.39704  ? 158 HIS A CA  1 
ATOM   946  C  C   . HIS A 1 158 ? -4.58949  -19.39475 -37.88117 1.000 44.31335  ? 158 HIS A C   1 
ATOM   947  O  O   . HIS A 1 158 ? -5.34792  -18.52712 -38.32831 1.000 51.61614  ? 158 HIS A O   1 
ATOM   948  C  CB  . HIS A 1 158 ? -3.61583  -17.83898 -36.18395 1.000 44.43380  ? 158 HIS A CB  1 
ATOM   949  C  CG  . HIS A 1 158 ? -4.70400  -16.89577 -35.77624 1.000 50.35591  ? 158 HIS A CG  1 
ATOM   950  N  ND1 . HIS A 1 158 ? -5.83666  -16.69200 -36.53459 1.000 52.53054  ? 158 HIS A ND1 1 
ATOM   951  C  CD2 . HIS A 1 158 ? -4.82846  -16.09474 -34.69175 1.000 51.17556  ? 158 HIS A CD2 1 
ATOM   952  C  CE1 . HIS A 1 158 ? -6.61261  -15.80734 -35.93417 1.000 48.90674  ? 158 HIS A CE1 1 
ATOM   953  N  NE2 . HIS A 1 158 ? -6.02406  -15.42947 -34.81388 1.000 54.08330  ? 158 HIS A NE2 1 
ATOM   954  N  N   . VAL A 1 159 ? -4.19168  -20.43102 -38.62586 1.000 51.48427  ? 159 VAL A N   1 
ATOM   955  C  CA  . VAL A 1 159 ? -4.59394  -20.52198 -40.03016 1.000 53.71674  ? 159 VAL A CA  1 
ATOM   956  C  C   . VAL A 1 159 ? -4.98560  -21.93721 -40.44992 1.000 51.81356  ? 159 VAL A C   1 
ATOM   957  O  O   . VAL A 1 159 ? -5.48041  -22.13714 -41.56498 1.000 60.38445  ? 159 VAL A O   1 
ATOM   958  C  CB  . VAL A 1 159 ? -3.48914  -19.98981 -40.96644 1.000 48.36807  ? 159 VAL A CB  1 
ATOM   959  C  CG1 . VAL A 1 159 ? -3.21099  -18.51023 -40.71691 1.000 57.47579  ? 159 VAL A CG1 1 
ATOM   960  C  CG2 . VAL A 1 159 ? -2.22773  -20.79989 -40.80711 1.000 45.95467  ? 159 VAL A CG2 1 
ATOM   961  N  N   . VAL A 1 160 ? -4.77295  -22.92960 -39.58847 1.000 51.06112  ? 160 VAL A N   1 
ATOM   962  C  CA  . VAL A 1 160 ? -5.11479  -24.30616 -39.94462 1.000 45.95473  ? 160 VAL A CA  1 
ATOM   963  C  C   . VAL A 1 160 ? -6.60070  -24.53477 -39.70432 1.000 50.71861  ? 160 VAL A C   1 
ATOM   964  O  O   . VAL A 1 160 ? -7.12124  -24.24286 -38.62092 1.000 53.39749  ? 160 VAL A O   1 
ATOM   965  C  CB  . VAL A 1 160 ? -4.26944  -25.31433 -39.15058 1.000 44.81684  ? 160 VAL A CB  1 
ATOM   966  C  CG1 . VAL A 1 160 ? -4.75981  -26.73349 -39.40986 1.000 39.92656  ? 160 VAL A CG1 1 
ATOM   967  C  CG2 . VAL A 1 160 ? -2.80092  -25.18140 -39.50226 1.000 37.49510  ? 160 VAL A CG2 1 
ATOM   968  N  N   . GLY A 1 161 ? -7.28485  -25.07102 -40.71212 1.000 50.42115  ? 161 GLY A N   1 
ATOM   969  C  CA  . GLY A 1 161 ? -8.70763  -25.32748 -40.60981 1.000 55.10250  ? 161 GLY A CA  1 
ATOM   970  C  C   . GLY A 1 161 ? -9.54403  -24.13479 -41.02235 1.000 55.12614  ? 161 GLY A C   1 
ATOM   971  O  O   . GLY A 1 161 ? -10.27075 -24.18802 -42.01863 1.000 53.69555  ? 161 GLY A O   1 
ATOM   972  N  N   . THR A 1 162 ? -9.45988  -23.05467 -40.25019 1.000 50.80297  ? 162 THR A N   1 
ATOM   973  C  CA  . THR A 1 162 ? -10.11177 -21.79141 -40.56370 1.000 49.52126  ? 162 THR A CA  1 
ATOM   974  C  C   . THR A 1 162 ? -9.09052  -20.66918 -40.42410 1.000 54.84101  ? 162 THR A C   1 
ATOM   975  O  O   . THR A 1 162 ? -7.93369  -20.89462 -40.05578 1.000 56.40238  ? 162 THR A O   1 
ATOM   976  C  CB  . THR A 1 162 ? -11.32366 -21.53323 -39.65539 1.000 53.46179  ? 162 THR A CB  1 
ATOM   977  O  OG1 . THR A 1 162 ? -10.87790 -21.02215 -38.39294 1.000 57.02305  ? 162 THR A OG1 1 
ATOM   978  C  CG2 . THR A 1 162 ? -12.12652 -22.81035 -39.43051 1.000 52.56773  ? 162 THR A CG2 1 
ATOM   979  N  N   . GLU A 1 163 ? -9.52734  -19.44292 -40.71461 1.000 59.68028  ? 163 GLU A N   1 
ATOM   980  C  CA  . GLU A 1 163 ? -8.66655  -18.27739 -40.54691 1.000 56.57992  ? 163 GLU A CA  1 
ATOM   981  C  C   . GLU A 1 163 ? -8.42425  -17.92681 -39.08519 1.000 54.19622  ? 163 GLU A C   1 
ATOM   982  O  O   . GLU A 1 163 ? -7.76191  -16.91976 -38.80988 1.000 57.68587  ? 163 GLU A O   1 
ATOM   983  C  CB  . GLU A 1 163 ? -9.26330  -17.07224 -41.27665 1.000 71.15291  ? 163 GLU A CB  1 
ATOM   984  C  CG  . GLU A 1 163 ? -9.19662  -17.16924 -42.79214 1.000 81.74281  ? 163 GLU A CG  1 
ATOM   985  C  CD  . GLU A 1 163 ? -9.48504  -15.84547 -43.47304 1.000 99.94556  ? 163 GLU A CD  1 
ATOM   986  O  OE1 . GLU A 1 163 ? -10.65218 -15.40088 -43.44189 1.000 100.72648 ? 163 GLU A OE1 1 
ATOM   987  O  OE2 . GLU A 1 163 ? -8.54349  -15.24701 -44.03554 1.000 104.67232 ? 163 GLU A OE2 1 
ATOM   988  N  N   . HIS A 1 164 ? -8.94459  -18.72146 -38.14866 1.000 49.43632  ? 164 HIS A N   1 
ATOM   989  C  CA  . HIS A 1 164 ? -8.69831  -18.52987 -36.72503 1.000 58.36354  ? 164 HIS A CA  1 
ATOM   990  C  C   . HIS A 1 164 ? -8.07314  -19.76614 -36.08855 1.000 56.21953  ? 164 HIS A C   1 
ATOM   991  O  O   . HIS A 1 164 ? -8.10045  -19.91189 -34.86224 1.000 60.79958  ? 164 HIS A O   1 
ATOM   992  C  CB  . HIS A 1 164 ? -9.99349  -18.14737 -36.00789 1.000 50.22305  ? 164 HIS A CB  1 
ATOM   993  C  CG  . HIS A 1 164 ? -10.56204 -16.83974 -36.46101 1.000 60.54277  ? 164 HIS A CG  1 
ATOM   994  N  ND1 . HIS A 1 164 ? -11.51618 -16.74636 -37.45122 1.000 58.21125  ? 164 HIS A ND1 1 
ATOM   995  C  CD2 . HIS A 1 164 ? -10.29647 -15.57002 -36.07300 1.000 56.47057  ? 164 HIS A CD2 1 
ATOM   996  C  CE1 . HIS A 1 164 ? -11.82109 -15.47601 -37.64707 1.000 60.05930  ? 164 HIS A CE1 1 
ATOM   997  N  NE2 . HIS A 1 164 ? -11.09422 -14.74162 -36.82424 1.000 63.38559  ? 164 HIS A NE2 1 
ATOM   998  N  N   . GLY A 1 165 ? -7.51247  -20.65837 -36.90150 1.000 51.37492  ? 165 GLY A N   1 
ATOM   999  C  CA  . GLY A 1 165 ? -6.81421  -21.81953 -36.38646 1.000 46.84907  ? 165 GLY A CA  1 
ATOM   1000 C  C   . GLY A 1 165 ? -7.68629  -22.82137 -35.66775 1.000 50.64325  ? 165 GLY A C   1 
ATOM   1001 O  O   . GLY A 1 165 ? -7.19268  -23.54341 -34.79599 1.000 56.54559  ? 165 GLY A O   1 
ATOM   1002 N  N   . THR A 1 166 ? -8.97647  -22.88641 -36.00785 1.000 48.29196  ? 166 THR A N   1 
ATOM   1003 C  CA  . THR A 1 166 ? -9.86314  -23.84483 -35.35451 1.000 49.21374  ? 166 THR A CA  1 
ATOM   1004 C  C   . THR A 1 166 ? -9.38592  -25.27447 -35.57850 1.000 47.57195  ? 166 THR A C   1 
ATOM   1005 O  O   . THR A 1 166 ? -9.44083  -26.10596 -34.66512 1.000 51.19577  ? 166 THR A O   1 
ATOM   1006 C  CB  . THR A 1 166 ? -11.29592 -23.66713 -35.86084 1.000 54.64056  ? 166 THR A CB  1 
ATOM   1007 O  OG1 . THR A 1 166 ? -11.73267 -22.32826 -35.59768 1.000 55.97668  ? 166 THR A OG1 1 
ATOM   1008 C  CG2 . THR A 1 166 ? -12.23969 -24.64252 -35.16675 1.000 48.56155  ? 166 THR A CG2 1 
ATOM   1009 N  N   . GLY A 1 167 ? -8.89505  -25.57423 -36.78211 1.000 48.21168  ? 167 GLY A N   1 
ATOM   1010 C  CA  . GLY A 1 167 ? -8.37947  -26.90715 -37.04403 1.000 46.61834  ? 167 GLY A CA  1 
ATOM   1011 C  C   . GLY A 1 167 ? -7.05776  -27.17190 -36.34799 1.000 51.30550  ? 167 GLY A C   1 
ATOM   1012 O  O   . GLY A 1 167 ? -6.85618  -28.24275 -35.76771 1.000 53.21110  ? 167 GLY A O   1 
ATOM   1013 N  N   . GLY A 1 168 ? -6.14071  -26.20271 -36.39235 1.000 49.82917  ? 168 GLY A N   1 
ATOM   1014 C  CA  . GLY A 1 168 ? -4.84496  -26.39695 -35.76037 1.000 48.26094  ? 168 GLY A CA  1 
ATOM   1015 C  C   . GLY A 1 168 ? -4.94704  -26.51833 -34.25292 1.000 51.34309  ? 168 GLY A C   1 
ATOM   1016 O  O   . GLY A 1 168 ? -4.32103  -27.38918 -33.64362 1.000 50.65907  ? 168 GLY A O   1 
ATOM   1017 N  N   . ILE A 1 169 ? -5.73886  -25.64019 -33.63128 1.000 48.29612  ? 169 ILE A N   1 
ATOM   1018 C  CA  . ILE A 1 169 ? -5.94625  -25.70950 -32.18710 1.000 42.42949  ? 169 ILE A CA  1 
ATOM   1019 C  C   . ILE A 1 169 ? -6.57039  -27.04465 -31.80388 1.000 49.47379  ? 169 ILE A C   1 
ATOM   1020 O  O   . ILE A 1 169 ? -6.16530  -27.67984 -30.82207 1.000 52.62225  ? 169 ILE A O   1 
ATOM   1021 C  CB  . ILE A 1 169 ? -6.81124  -24.52559 -31.71685 1.000 45.83768  ? 169 ILE A CB  1 
ATOM   1022 C  CG1 . ILE A 1 169 ? -6.01749  -23.21913 -31.77504 1.000 48.71257  ? 169 ILE A CG1 1 
ATOM   1023 C  CG2 . ILE A 1 169 ? -7.34147  -24.77346 -30.31924 1.000 42.62095  ? 169 ILE A CG2 1 
ATOM   1024 C  CD1 . ILE A 1 169 ? -6.88537  -21.98012 -31.71841 1.000 41.55528  ? 169 ILE A CD1 1 
ATOM   1025 N  N   . ARG A 1 170 ? -7.56275  -27.49277 -32.57617 1.000 50.25379  ? 170 ARG A N   1 
ATOM   1026 C  CA  . ARG A 1 170 ? -8.18575  -28.78649 -32.31635 1.000 52.59354  ? 170 ARG A CA  1 
ATOM   1027 C  C   . ARG A 1 170 ? -7.17789  -29.92100 -32.44228 1.000 53.95621  ? 170 ARG A C   1 
ATOM   1028 O  O   . ARG A 1 170 ? -7.18617  -30.86159 -31.63969 1.000 47.63195  ? 170 ARG A O   1 
ATOM   1029 C  CB  . ARG A 1 170 ? -9.35367  -29.00048 -33.27811 1.000 50.10413  ? 170 ARG A CB  1 
ATOM   1030 C  CG  . ARG A 1 170 ? -10.27374 -30.15419 -32.92389 1.000 52.64014  ? 170 ARG A CG  1 
ATOM   1031 C  CD  . ARG A 1 170 ? -11.18972 -30.47119 -34.09559 1.000 64.82488  ? 170 ARG A CD  1 
ATOM   1032 N  NE  . ARG A 1 170 ? -12.41125 -29.67573 -34.05935 1.000 83.35139  ? 170 ARG A NE  1 
ATOM   1033 C  CZ  . ARG A 1 170 ? -12.88551 -28.98487 -35.08777 1.000 90.43427  ? 170 ARG A CZ  1 
ATOM   1034 N  NH1 . ARG A 1 170 ? -12.25823 -28.95995 -36.25347 1.000 80.29867  ? 170 ARG A NH1 1 
ATOM   1035 N  NH2 . ARG A 1 170 ? -14.01491 -28.29748 -34.94229 1.000 84.68866  ? 170 ARG A NH2 1 
ATOM   1036 N  N   . ASN A 1 171 ? -6.29577  -29.84719 -33.43939 1.000 50.84114  ? 171 ASN A N   1 
ATOM   1037 C  CA  . ASN A 1 171 ? -5.34154  -30.92171 -33.67350 1.000 46.33397  ? 171 ASN A CA  1 
ATOM   1038 C  C   . ASN A 1 171 ? -4.19655  -30.92537 -32.66985 1.000 49.65189  ? 171 ASN A C   1 
ATOM   1039 O  O   . ASN A 1 171 ? -3.47595  -31.92480 -32.58065 1.000 48.70548  ? 171 ASN A O   1 
ATOM   1040 C  CB  . ASN A 1 171 ? -4.79121  -30.82951 -35.09690 1.000 52.58820  ? 171 ASN A CB  1 
ATOM   1041 C  CG  . ASN A 1 171 ? -5.83419  -31.16882 -36.14560 1.000 57.62152  ? 171 ASN A CG  1 
ATOM   1042 O  OD1 . ASN A 1 171 ? -6.81157  -31.86225 -35.86319 1.000 52.32593  ? 171 ASN A OD1 1 
ATOM   1043 N  ND2 . ASN A 1 171 ? -5.63162  -30.67890 -37.36378 1.000 56.35479  ? 171 ASN A ND2 1 
ATOM   1044 N  N   . GLY A 1 172 ? -4.00950  -29.84239 -31.91935 1.000 44.10951  ? 172 GLY A N   1 
ATOM   1045 C  CA  . GLY A 1 172 ? -3.02593  -29.83819 -30.85485 1.000 43.49412  ? 172 GLY A CA  1 
ATOM   1046 C  C   . GLY A 1 172 ? -1.95572  -28.77417 -30.97552 1.000 50.01257  ? 172 GLY A C   1 
ATOM   1047 O  O   . GLY A 1 172 ? -0.98057  -28.78079 -30.21770 1.000 45.56527  ? 172 GLY A O   1 
ATOM   1048 N  N   . LEU A 1 173 ? -2.12225  -27.84846 -31.91984 1.000 47.69457  ? 173 LEU A N   1 
ATOM   1049 C  CA  . LEU A 1 173 ? -1.13628  -26.79106 -32.14125 1.000 42.20605  ? 173 LEU A CA  1 
ATOM   1050 C  C   . LEU A 1 173 ? -1.35687  -25.66543 -31.12930 1.000 44.11416  ? 173 LEU A C   1 
ATOM   1051 O  O   . LEU A 1 173 ? -1.85247  -24.58121 -31.44107 1.000 45.98262  ? 173 LEU A O   1 
ATOM   1052 C  CB  . LEU A 1 173 ? -1.20994  -26.28354 -33.57410 1.000 43.03688  ? 173 LEU A CB  1 
ATOM   1053 C  CG  . LEU A 1 173 ? -0.57878  -27.19335 -34.62887 1.000 37.98448  ? 173 LEU A CG  1 
ATOM   1054 C  CD1 . LEU A 1 173 ? -0.87470  -26.67980 -36.02801 1.000 36.56350  ? 173 LEU A CD1 1 
ATOM   1055 C  CD2 . LEU A 1 173 ? 0.91968   -27.30836 -34.40273 1.000 36.44728  ? 173 LEU A CD2 1 
ATOM   1056 N  N   . TYR A 1 174 ? -0.97095  -25.94799 -29.88608 1.000 44.51995  ? 174 TYR A N   1 
ATOM   1057 C  CA  . TYR A 1 174 ? -1.03052  -24.96623 -28.81279 1.000 37.24480  ? 174 TYR A CA  1 
ATOM   1058 C  C   . TYR A 1 174 ? 0.07523   -25.26535 -27.81074 1.000 38.52917  ? 174 TYR A C   1 
ATOM   1059 O  O   . TYR A 1 174 ? 0.53183   -26.40512 -27.69213 1.000 36.80029  ? 174 TYR A O   1 
ATOM   1060 C  CB  . TYR A 1 174 ? -2.40073  -24.95854 -28.11846 1.000 35.11726  ? 174 TYR A CB  1 
ATOM   1061 C  CG  . TYR A 1 174 ? -2.89237  -26.32125 -27.67435 1.000 43.46569  ? 174 TYR A CG  1 
ATOM   1062 C  CD1 . TYR A 1 174 ? -2.34377  -26.95583 -26.56569 1.000 47.21999  ? 174 TYR A CD1 1 
ATOM   1063 C  CD2 . TYR A 1 174 ? -3.91406  -26.96769 -28.35738 1.000 40.98841  ? 174 TYR A CD2 1 
ATOM   1064 C  CE1 . TYR A 1 174 ? -2.78888  -28.19843 -26.15894 1.000 40.99007  ? 174 TYR A CE1 1 
ATOM   1065 C  CE2 . TYR A 1 174 ? -4.36970  -28.20990 -27.95449 1.000 46.04453  ? 174 TYR A CE2 1 
ATOM   1066 C  CZ  . TYR A 1 174 ? -3.80380  -28.81937 -26.85388 1.000 50.56064  ? 174 TYR A CZ  1 
ATOM   1067 O  OH  . TYR A 1 174 ? -4.25107  -30.05559 -26.44760 1.000 49.66192  ? 174 TYR A OH  1 
ATOM   1068 N  N   . GLY A 1 175 ? 0.50044   -24.23152 -27.08911 1.000 35.99564  ? 175 GLY A N   1 
ATOM   1069 C  CA  . GLY A 1 175 ? 1.55587   -24.37309 -26.11549 1.000 34.27161  ? 175 GLY A CA  1 
ATOM   1070 C  C   . GLY A 1 175 ? 1.64959   -23.18253 -25.18481 1.000 38.91598  ? 175 GLY A C   1 
ATOM   1071 O  O   . GLY A 1 175 ? 1.22586   -22.07180 -25.51589 1.000 40.66070  ? 175 GLY A O   1 
ATOM   1072 N  N   . PRO A 1 176 ? 2.21803   -23.39196 -23.99996 1.000 45.29705  ? 176 PRO A N   1 
ATOM   1073 C  CA  . PRO A 1 176 ? 2.27909   -22.32701 -22.99659 1.000 39.84704  ? 176 PRO A CA  1 
ATOM   1074 C  C   . PRO A 1 176 ? 3.50806   -21.44216 -23.12813 1.000 42.51761  ? 176 PRO A C   1 
ATOM   1075 O  O   . PRO A 1 176 ? 4.57619   -21.86284 -23.57679 1.000 44.49784  ? 176 PRO A O   1 
ATOM   1076 C  CB  . PRO A 1 176 ? 2.32465   -23.11767 -21.68287 1.000 40.80217  ? 176 PRO A CB  1 
ATOM   1077 C  CG  . PRO A 1 176 ? 3.12636   -24.32966 -22.04853 1.000 37.74947  ? 176 PRO A CG  1 
ATOM   1078 C  CD  . PRO A 1 176 ? 2.74051   -24.66796 -23.47635 1.000 41.33660  ? 176 PRO A CD  1 
ATOM   1079 N  N   . VAL A 1 177 ? 3.33172   -20.18537 -22.72140 1.000 37.98941  ? 177 VAL A N   1 
ATOM   1080 C  CA  . VAL A 1 177 ? 4.41860   -19.21853 -22.61709 1.000 41.02496  ? 177 VAL A CA  1 
ATOM   1081 C  C   . VAL A 1 177 ? 4.37829   -18.60859 -21.22469 1.000 42.83996  ? 177 VAL A C   1 
ATOM   1082 O  O   . VAL A 1 177 ? 3.32630   -18.13620 -20.78060 1.000 50.21636  ? 177 VAL A O   1 
ATOM   1083 C  CB  . VAL A 1 177 ? 4.32640   -18.10749 -23.68140 1.000 44.69672  ? 177 VAL A CB  1 
ATOM   1084 C  CG1 . VAL A 1 177 ? 5.67168   -17.41234 -23.82840 1.000 42.13928  ? 177 VAL A CG1 1 
ATOM   1085 C  CG2 . VAL A 1 177 ? 3.86278   -18.66345 -25.01287 1.000 39.79543  ? 177 VAL A CG2 1 
ATOM   1086 N  N   . ILE A 1 178 ? 5.51754   -18.61561 -20.54040 1.000 43.53638  ? 178 ILE A N   1 
ATOM   1087 C  CA  . ILE A 1 178 ? 5.65307   -17.99971 -19.22600 1.000 39.23851  ? 178 ILE A CA  1 
ATOM   1088 C  C   . ILE A 1 178 ? 6.62682   -16.83844 -19.35080 1.000 43.87853  ? 178 ILE A C   1 
ATOM   1089 O  O   . ILE A 1 178 ? 7.77708   -17.02364 -19.76694 1.000 45.74677  ? 178 ILE A O   1 
ATOM   1090 C  CB  . ILE A 1 178 ? 6.13178   -19.00375 -18.16635 1.000 42.38596  ? 178 ILE A CB  1 
ATOM   1091 C  CG1 . ILE A 1 178 ? 5.09077   -20.10322 -17.95432 1.000 44.19996  ? 178 ILE A CG1 1 
ATOM   1092 C  CG2 . ILE A 1 178 ? 6.43349   -18.28937 -16.85669 1.000 39.00040  ? 178 ILE A CG2 1 
ATOM   1093 C  CD1 . ILE A 1 178 ? 5.47943   -21.10690 -16.88974 1.000 44.80612  ? 178 ILE A CD1 1 
ATOM   1094 N  N   . VAL A 1 179 ? 6.16621   -15.64244 -19.00200 1.000 41.93543  ? 179 VAL A N   1 
ATOM   1095 C  CA  . VAL A 1 179 ? 7.01830   -14.46473 -18.90523 1.000 40.40103  ? 179 VAL A CA  1 
ATOM   1096 C  C   . VAL A 1 179 ? 7.11048   -14.09521 -17.43390 1.000 43.54878  ? 179 VAL A C   1 
ATOM   1097 O  O   . VAL A 1 179 ? 6.09884   -13.75549 -16.80757 1.000 48.86078  ? 179 VAL A O   1 
ATOM   1098 C  CB  . VAL A 1 179 ? 6.47793   -13.29489 -19.73981 1.000 45.78900  ? 179 VAL A CB  1 
ATOM   1099 C  CG1 . VAL A 1 179 ? 7.41298   -12.09835 -19.63348 1.000 38.22428  ? 179 VAL A CG1 1 
ATOM   1100 C  CG2 . VAL A 1 179 ? 6.30150   -13.71786 -21.18980 1.000 36.19502  ? 179 VAL A CG2 1 
ATOM   1101 N  N   . ARG A 1 180 ? 8.31447   -14.17181 -16.88024 1.000 42.69599  ? 180 ARG A N   1 
ATOM   1102 C  CA  . ARG A 1 180 ? 8.53306   -13.92430 -15.46447 1.000 48.33810  ? 180 ARG A CA  1 
ATOM   1103 C  C   . ARG A 1 180 ? 8.97378   -12.48649 -15.22441 1.000 47.04512  ? 180 ARG A C   1 
ATOM   1104 O  O   . ARG A 1 180 ? 9.67155   -11.88210 -16.04280 1.000 52.82962  ? 180 ARG A O   1 
ATOM   1105 C  CB  . ARG A 1 180 ? 9.58147   -14.88306 -14.89979 1.000 39.80195  ? 180 ARG A CB  1 
ATOM   1106 C  CG  . ARG A 1 180 ? 9.35842   -16.33383 -15.27285 1.000 47.75071  ? 180 ARG A CG  1 
ATOM   1107 C  CD  . ARG A 1 180 ? 9.40747   -17.21677 -14.04231 1.000 45.20705  ? 180 ARG A CD  1 
ATOM   1108 N  NE  . ARG A 1 180 ? 9.28635   -18.63146 -14.37167 1.000 44.55412  ? 180 ARG A NE  1 
ATOM   1109 C  CZ  . ARG A 1 180 ? 8.30261   -19.41476 -13.95248 1.000 41.98406  ? 180 ARG A CZ  1 
ATOM   1110 N  NH1 . ARG A 1 180 ? 7.32686   -18.95002 -13.18977 1.000 46.16264  ? 180 ARG A NH1 1 
ATOM   1111 N  NH2 . ARG A 1 180 ? 8.29855   -20.69661 -14.30603 1.000 45.01391  ? 180 ARG A NH2 1 
ATOM   1112 N  N   . ARG A 1 181 ? 8.54901   -11.94433 -14.08931 1.000 46.64864  ? 181 ARG A N   1 
ATOM   1113 C  CA  . ARG A 1 181 ? 9.01352   -10.64848 -13.62522 1.000 43.51117  ? 181 ARG A CA  1 
ATOM   1114 C  C   . ARG A 1 181 ? 10.18566  -10.84680 -12.67350 1.000 47.58475  ? 181 ARG A C   1 
ATOM   1115 O  O   . ARG A 1 181 ? 10.26143  -11.84812 -11.95651 1.000 49.44841  ? 181 ARG A O   1 
ATOM   1116 C  CB  . ARG A 1 181 ? 7.88202   -9.88526  -12.93066 1.000 41.93151  ? 181 ARG A CB  1 
ATOM   1117 C  CG  . ARG A 1 181 ? 8.28399   -8.53499  -12.35559 1.000 42.83768  ? 181 ARG A CG  1 
ATOM   1118 C  CD  . ARG A 1 181 ? 7.09472   -7.59850  -12.24845 1.000 42.73993  ? 181 ARG A CD  1 
ATOM   1119 N  NE  . ARG A 1 181 ? 6.41760   -7.43028  -13.52819 1.000 46.92300  ? 181 ARG A NE  1 
ATOM   1120 C  CZ  . ARG A 1 181 ? 5.11316   -7.23641  -13.66468 1.000 53.47674  ? 181 ARG A CZ  1 
ATOM   1121 N  NH1 . ARG A 1 181 ? 4.31078   -7.17004  -12.61490 1.000 51.48952  ? 181 ARG A NH1 1 
ATOM   1122 N  NH2 . ARG A 1 181 ? 4.60059   -7.10692  -14.88513 1.000 50.33334  ? 181 ARG A NH2 1 
ATOM   1123 N  N   . LYS A 1 182 ? 11.11419  -9.89313  -12.69098 1.000 46.38917  ? 182 LYS A N   1 
ATOM   1124 C  CA  . LYS A 1 182 ? 12.27604  -9.95994  -11.81379 1.000 52.60919  ? 182 LYS A CA  1 
ATOM   1125 C  C   . LYS A 1 182 ? 11.83204  -10.05720 -10.35987 1.000 54.12243  ? 182 LYS A C   1 
ATOM   1126 O  O   . LYS A 1 182 ? 11.09709  -9.19652  -9.86566  1.000 47.61824  ? 182 LYS A O   1 
ATOM   1127 C  CB  . LYS A 1 182 ? 13.16275  -8.73429  -12.02430 1.000 50.47330  ? 182 LYS A CB  1 
ATOM   1128 C  CG  . LYS A 1 182 ? 14.36050  -8.66942  -11.09368 1.000 57.37388  ? 182 LYS A CG  1 
ATOM   1129 C  CD  . LYS A 1 182 ? 14.57417  -7.26236  -10.56579 1.000 74.86412  ? 182 LYS A CD  1 
ATOM   1130 C  CE  . LYS A 1 182 ? 15.90362  -7.14465  -9.84038  1.000 78.54296  ? 182 LYS A CE  1 
ATOM   1131 N  NZ  . LYS A 1 182 ? 16.43734  -5.75629  -9.88572  1.000 90.02912  ? 182 LYS A NZ  1 
ATOM   1132 N  N   . GLY A 1 183 ? 12.26852  -11.11638 -9.68066  1.000 46.49270  ? 183 GLY A N   1 
ATOM   1133 C  CA  . GLY A 1 183 ? 11.87814  -11.37548 -8.31279  1.000 46.60093  ? 183 GLY A CA  1 
ATOM   1134 C  C   . GLY A 1 183 ? 10.77585  -12.40032 -8.14954  1.000 51.47054  ? 183 GLY A C   1 
ATOM   1135 O  O   . GLY A 1 183 ? 10.47942  -12.78662 -7.01211  1.000 60.89918  ? 183 GLY A O   1 
ATOM   1136 N  N   . ASP A 1 184 ? 10.16053  -12.84530 -9.24421  1.000 51.37822  ? 184 ASP A N   1 
ATOM   1137 C  CA  . ASP A 1 184 ? 9.11791   -13.85945 -9.16156  1.000 46.53759  ? 184 ASP A CA  1 
ATOM   1138 C  C   . ASP A 1 184 ? 9.67684   -15.15366 -8.58661  1.000 50.93882  ? 184 ASP A C   1 
ATOM   1139 O  O   . ASP A 1 184 ? 10.78717  -15.57215 -8.92141  1.000 52.19314  ? 184 ASP A O   1 
ATOM   1140 C  CB  . ASP A 1 184 ? 8.52012   -14.12310 -10.54457 1.000 48.96157  ? 184 ASP A CB  1 
ATOM   1141 C  CG  . ASP A 1 184 ? 7.41869   -13.14762 -10.90170 1.000 56.29060  ? 184 ASP A CG  1 
ATOM   1142 O  OD1 . ASP A 1 184 ? 7.09564   -12.27738 -10.06491 1.000 65.05610  ? 184 ASP A OD1 1 
ATOM   1143 O  OD2 . ASP A 1 184 ? 6.87551   -13.25247 -12.02217 1.000 51.29709  ? 184 ASP A OD2 1 
ATOM   1144 N  N   . VAL A 1 185 ? 8.89292   -15.79492 -7.72077  1.000 50.40919  ? 185 VAL A N   1 
ATOM   1145 C  CA  . VAL A 1 185 ? 9.32704   -17.03927 -7.09928  1.000 44.70631  ? 185 VAL A CA  1 
ATOM   1146 C  C   . VAL A 1 185 ? 9.32115   -18.15157 -8.13858  1.000 45.43787  ? 185 VAL A C   1 
ATOM   1147 O  O   . VAL A 1 185 ? 8.33730   -18.33989 -8.86621  1.000 50.27321  ? 185 VAL A O   1 
ATOM   1148 C  CB  . VAL A 1 185 ? 8.42825   -17.38502 -5.90335  1.000 45.85216  ? 185 VAL A CB  1 
ATOM   1149 C  CG1 . VAL A 1 185 ? 8.72179   -18.78820 -5.41028  1.000 48.55676  ? 185 VAL A CG1 1 
ATOM   1150 C  CG2 . VAL A 1 185 ? 8.62258   -16.37412 -4.78682  1.000 47.77308  ? 185 VAL A CG2 1 
ATOM   1151 N  N   . LEU A 1 186 ? 10.42497  -18.89463 -8.21386  1.000 49.41946  ? 186 LEU A N   1 
ATOM   1152 C  CA  . LEU A 1 186 ? 10.58720  -19.97589 -9.17824  1.000 46.50027  ? 186 LEU A CA  1 
ATOM   1153 C  C   . LEU A 1 186 ? 10.16892  -21.30930 -8.56308  1.000 48.40603  ? 186 LEU A C   1 
ATOM   1154 O  O   . LEU A 1 186 ? 10.47365  -21.57962 -7.39745  1.000 49.74737  ? 186 LEU A O   1 
ATOM   1155 C  CB  . LEU A 1 186 ? 12.03398  -20.06368 -9.65123  1.000 45.95488  ? 186 LEU A CB  1 
ATOM   1156 C  CG  . LEU A 1 186 ? 12.56923  -18.81951 -10.36035 1.000 47.27715  ? 186 LEU A CG  1 
ATOM   1157 C  CD1 . LEU A 1 186 ? 14.01466  -19.02008 -10.77756 1.000 46.88170  ? 186 LEU A CD1 1 
ATOM   1158 C  CD2 . LEU A 1 186 ? 11.70526  -18.48218 -11.56171 1.000 45.19098  ? 186 LEU A CD2 1 
ATOM   1159 N  N   . PRO A 1 187 ? 9.47871   -22.15185 -9.33013  1.000 51.67771  ? 187 PRO A N   1 
ATOM   1160 C  CA  . PRO A 1 187 ? 8.98199   -23.41789 -8.77818  1.000 47.65527  ? 187 PRO A CA  1 
ATOM   1161 C  C   . PRO A 1 187 ? 9.98926   -24.54963 -8.88954  1.000 46.53285  ? 187 PRO A C   1 
ATOM   1162 O  O   . PRO A 1 187 ? 11.06385  -24.38299 -9.47448  1.000 49.38701  ? 187 PRO A O   1 
ATOM   1163 C  CB  . PRO A 1 187 ? 7.74552   -23.69664 -9.63626  1.000 42.30644  ? 187 PRO A CB  1 
ATOM   1164 C  CG  . PRO A 1 187 ? 8.11870   -23.12252 -10.97720 1.000 46.90699  ? 187 PRO A CG  1 
ATOM   1165 C  CD  . PRO A 1 187 ? 9.04139   -21.94802 -10.72269 1.000 43.32716  ? 187 PRO A CD  1 
ATOM   1166 N  N   . ASP A 1 188 ? 9.64408   -25.71086 -8.32857  1.000 46.06299  ? 188 ASP A N   1 
ATOM   1167 C  CA  . ASP A 1 188 ? 10.46059  -26.90376 -8.51712  1.000 48.89353  ? 188 ASP A CA  1 
ATOM   1168 C  C   . ASP A 1 188 ? 10.14912  -27.59219 -9.83821  1.000 46.33037  ? 188 ASP A C   1 
ATOM   1169 O  O   . ASP A 1 188 ? 11.03516  -28.21326 -10.43505 1.000 51.21802  ? 188 ASP A O   1 
ATOM   1170 C  CB  . ASP A 1 188 ? 10.24901  -27.88097 -7.35917  1.000 48.10297  ? 188 ASP A CB  1 
ATOM   1171 C  CG  . ASP A 1 188 ? 10.77541  -27.34805 -6.04131  1.000 56.11474  ? 188 ASP A CG  1 
ATOM   1172 O  OD1 . ASP A 1 188 ? 11.89766  -26.80058 -6.02476  1.000 66.56758  ? 188 ASP A OD1 1 
ATOM   1173 O  OD2 . ASP A 1 188 ? 10.06657  -27.47948 -5.02047  1.000 54.40544  ? 188 ASP A OD2 1 
ATOM   1174 N  N   . ALA A 1 189 ? 8.90677   -27.49468 -10.30290 1.000 44.18551  ? 189 ALA A N   1 
ATOM   1175 C  CA  . ALA A 1 189 ? 8.50301   -28.08163 -11.57127 1.000 41.54085  ? 189 ALA A CA  1 
ATOM   1176 C  C   . ALA A 1 189 ? 7.29501   -27.31982 -12.09086 1.000 44.38438  ? 189 ALA A C   1 
ATOM   1177 O  O   . ALA A 1 189 ? 6.56890   -26.67746 -11.32786 1.000 42.92445  ? 189 ALA A O   1 
ATOM   1178 C  CB  . ALA A 1 189 ? 8.18054   -29.57216 -11.42982 1.000 41.97874  ? 189 ALA A CB  1 
ATOM   1179 N  N   . THR A 1 190 ? 7.08967   -27.40150 -13.40345 1.000 42.15155  ? 190 THR A N   1 
ATOM   1180 C  CA  . THR A 1 190 ? 5.97050   -26.74525 -14.06447 1.000 38.12893  ? 190 THR A CA  1 
ATOM   1181 C  C   . THR A 1 190 ? 5.22087   -27.76269 -14.90922 1.000 42.76173  ? 190 THR A C   1 
ATOM   1182 O  O   . THR A 1 190 ? 5.82580   -28.46041 -15.72919 1.000 53.84853  ? 190 THR A O   1 
ATOM   1183 C  CB  . THR A 1 190 ? 6.44249   -25.58017 -14.94041 1.000 37.91062  ? 190 THR A CB  1 
ATOM   1184 O  OG1 . THR A 1 190 ? 7.21125   -24.66721 -14.14881 1.000 47.21131  ? 190 THR A OG1 1 
ATOM   1185 C  CG2 . THR A 1 190 ? 5.25085   -24.84490 -15.53708 1.000 38.86517  ? 190 THR A CG2 1 
ATOM   1186 N  N   . HIS A 1 191 ? 3.90896   -27.84227 -14.71101 1.000 38.31903  ? 191 HIS A N   1 
ATOM   1187 C  CA  . HIS A 1 191 ? 3.05071   -28.73728 -15.47176 1.000 43.06706  ? 191 HIS A CA  1 
ATOM   1188 C  C   . HIS A 1 191 ? 2.01536   -27.92582 -16.23574 1.000 43.87668  ? 191 HIS A C   1 
ATOM   1189 O  O   . HIS A 1 191 ? 1.48839   -26.93284 -15.72408 1.000 45.52694  ? 191 HIS A O   1 
ATOM   1190 C  CB  . HIS A 1 191 ? 2.35845   -29.74964 -14.55681 1.000 37.87471  ? 191 HIS A CB  1 
ATOM   1191 C  CG  . HIS A 1 191 ? 3.30415   -30.52439 -13.69362 1.000 52.81416  ? 191 HIS A CG  1 
ATOM   1192 N  ND1 . HIS A 1 191 ? 3.94771   -31.66240 -14.13043 1.000 49.71850  ? 191 HIS A ND1 1 
ATOM   1193 C  CD2 . HIS A 1 191 ? 3.71888   -30.32274 -12.42059 1.000 40.19877  ? 191 HIS A CD2 1 
ATOM   1194 C  CE1 . HIS A 1 191 ? 4.71638   -32.12956 -13.16299 1.000 45.96971  ? 191 HIS A CE1 1 
ATOM   1195 N  NE2 . HIS A 1 191 ? 4.59536   -31.33524 -12.11463 1.000 47.09137  ? 191 HIS A NE2 1 
ATOM   1196 N  N   . THR A 1 192 ? 1.72997   -28.35114 -17.46210 1.000 46.51799  ? 192 THR A N   1 
ATOM   1197 C  CA  . THR A 1 192 ? 0.77628   -27.67548 -18.33166 1.000 40.44314  ? 192 THR A CA  1 
ATOM   1198 C  C   . THR A 1 192 ? -0.44670  -28.56216 -18.51241 1.000 45.26076  ? 192 THR A C   1 
ATOM   1199 O  O   . THR A 1 192 ? -0.32737  -29.71070 -18.95204 1.000 54.85475  ? 192 THR A O   1 
ATOM   1200 C  CB  . THR A 1 192 ? 1.39933   -27.34575 -19.68819 1.000 49.29074  ? 192 THR A CB  1 
ATOM   1201 O  OG1 . THR A 1 192 ? 2.68338   -26.73870 -19.49446 1.000 51.80570  ? 192 THR A OG1 1 
ATOM   1202 C  CG2 . THR A 1 192 ? 0.50185   -26.39568 -20.46657 1.000 47.32662  ? 192 THR A CG2 1 
ATOM   1203 N  N   . ILE A 1 193 ? -1.61379  -28.03052 -18.16584 1.000 47.93355  ? 193 ILE A N   1 
ATOM   1204 C  CA  . ILE A 1 193 ? -2.89026  -28.69635 -18.38685 1.000 44.41833  ? 193 ILE A CA  1 
ATOM   1205 C  C   . ILE A 1 193 ? -3.71837  -27.79717 -19.28961 1.000 49.19102  ? 193 ILE A C   1 
ATOM   1206 O  O   . ILE A 1 193 ? -4.02904  -26.65693 -18.92284 1.000 52.23027  ? 193 ILE A O   1 
ATOM   1207 C  CB  . ILE A 1 193 ? -3.62639  -28.98489 -17.06981 1.000 53.66830  ? 193 ILE A CB  1 
ATOM   1208 C  CG1 . ILE A 1 193 ? -2.75446  -29.83994 -16.14962 1.000 52.75919  ? 193 ILE A CG1 1 
ATOM   1209 C  CG2 . ILE A 1 193 ? -4.95226  -29.67382 -17.34251 1.000 48.56955  ? 193 ILE A CG2 1 
ATOM   1210 C  CD1 . ILE A 1 193 ? -3.05262  -29.64954 -14.68292 1.000 54.44740  ? 193 ILE A CD1 1 
ATOM   1211 N  N   . VAL A 1 194 ? -4.06588  -28.30132 -20.46813 1.000 48.96977  ? 194 VAL A N   1 
ATOM   1212 C  CA  . VAL A 1 194 ? -4.80069  -27.53649 -21.46625 1.000 48.72187  ? 194 VAL A CA  1 
ATOM   1213 C  C   . VAL A 1 194 ? -6.16871  -28.17475 -21.64633 1.000 49.45372  ? 194 VAL A C   1 
ATOM   1214 O  O   . VAL A 1 194 ? -6.27172  -29.36672 -21.96322 1.000 50.06947  ? 194 VAL A O   1 
ATOM   1215 C  CB  . VAL A 1 194 ? -4.04684  -27.46406 -22.80189 1.000 44.39258  ? 194 VAL A CB  1 
ATOM   1216 C  CG1 . VAL A 1 194 ? -4.90665  -26.77552 -23.84932 1.000 45.65513  ? 194 VAL A CG1 1 
ATOM   1217 C  CG2 . VAL A 1 194 ? -2.72732  -26.73251 -22.62343 1.000 48.77670  ? 194 VAL A CG2 1 
ATOM   1218 N  N   A LEU A 1 195 ? -7.21797  -27.38821 -21.41958 0.727 48.63869  ? 195 LEU A N   1 
ATOM   1219 N  N   B LEU A 1 195 ? -7.21840  -27.37597 -21.46598 0.273 48.45210  ? 195 LEU A N   1 
ATOM   1220 C  CA  A LEU A 1 195 ? -8.59176  -27.83245 -21.64011 0.727 50.87673  ? 195 LEU A CA  1 
ATOM   1221 C  CA  B LEU A 1 195 ? -8.59603  -27.83508 -21.63525 0.273 50.80396  ? 195 LEU A CA  1 
ATOM   1222 C  C   A LEU A 1 195 ? -8.95301  -27.52369 -23.08587 0.727 50.86638  ? 195 LEU A C   1 
ATOM   1223 C  C   B LEU A 1 195 ? -9.01645  -27.54207 -23.07073 0.273 50.74034  ? 195 LEU A C   1 
ATOM   1224 O  O   A LEU A 1 195 ? -9.36404  -26.40808 -23.41296 0.727 54.11044  ? 195 LEU A O   1 
ATOM   1225 O  O   B LEU A 1 195 ? -9.53323  -26.46910 -23.38462 0.273 53.73849  ? 195 LEU A O   1 
ATOM   1226 C  CB  A LEU A 1 195 ? -9.54703  -27.15157 -20.66724 0.727 51.40722  ? 195 LEU A CB  1 
ATOM   1227 C  CB  B LEU A 1 195 ? -9.51343  -27.15839 -20.62383 0.273 51.19061  ? 195 LEU A CB  1 
ATOM   1228 C  CG  A LEU A 1 195 ? -9.99428  -28.00906 -19.48392 0.727 54.33931  ? 195 LEU A CG  1 
ATOM   1229 C  CG  B LEU A 1 195 ? -9.02947  -27.13283 -19.16975 0.273 51.40180  ? 195 LEU A CG  1 
ATOM   1230 C  CD1 A LEU A 1 195 ? -10.48895 -27.14677 -18.33393 0.727 55.20965  ? 195 LEU A CD1 1 
ATOM   1231 C  CD1 B LEU A 1 195 ? -8.32574  -25.82335 -18.84886 0.273 52.53947  ? 195 LEU A CD1 1 
ATOM   1232 C  CD2 A LEU A 1 195 ? -11.06061 -29.00546 -19.91558 0.727 55.29532  ? 195 LEU A CD2 1 
ATOM   1233 C  CD2 B LEU A 1 195 ? -10.18387 -27.35850 -18.21043 0.273 54.68380  ? 195 LEU A CD2 1 
ATOM   1234 N  N   . ASN A 1 196 ? -8.78834  -28.51093 -23.95703 1.000 46.66922  ? 196 ASN A N   1 
ATOM   1235 C  CA  . ASN A 1 196 ? -9.10066  -28.37705 -25.37797 1.000 53.26576  ? 196 ASN A CA  1 
ATOM   1236 C  C   . ASN A 1 196 ? -10.39791 -29.13043 -25.64704 1.000 48.56100  ? 196 ASN A C   1 
ATOM   1237 O  O   . ASN A 1 196 ? -10.39911 -30.35827 -25.77226 1.000 48.30173  ? 196 ASN A O   1 
ATOM   1238 C  CB  . ASN A 1 196 ? -7.95549  -28.90209 -26.23804 1.000 55.23149  ? 196 ASN A CB  1 
ATOM   1239 C  CG  . ASN A 1 196 ? -8.06764  -28.46488 -27.68337 1.000 54.62129  ? 196 ASN A CG  1 
ATOM   1240 O  OD1 . ASN A 1 196 ? -8.63003  -27.41070 -27.98295 1.000 59.06456  ? 196 ASN A OD1 1 
ATOM   1241 N  ND2 . ASN A 1 196 ? -7.53095  -29.27319 -28.58946 1.000 54.56843  ? 196 ASN A ND2 1 
ATOM   1242 N  N   . ASP A 1 197 ? -11.50108 -28.38651 -25.73756 1.000 48.39976  ? 197 ASP A N   1 
ATOM   1243 C  CA  . ASP A 1 197 ? -12.84455 -28.94501 -25.91976 1.000 55.08764  ? 197 ASP A CA  1 
ATOM   1244 C  C   . ASP A 1 197 ? -13.10699 -29.90368 -24.76362 1.000 63.25903  ? 197 ASP A C   1 
ATOM   1245 O  O   . ASP A 1 197 ? -13.06510 -29.46430 -23.60288 1.000 69.07942  ? 197 ASP A O   1 
ATOM   1246 C  CB  . ASP A 1 197 ? -12.96366 -29.54632 -27.32176 1.000 55.02375  ? 197 ASP A CB  1 
ATOM   1247 C  CG  . ASP A 1 197 ? -13.11081 -28.49037 -28.39799 1.000 67.98820  ? 197 ASP A CG  1 
ATOM   1248 O  OD1 . ASP A 1 197 ? -12.50345 -28.65064 -29.47770 1.000 67.34032  ? 197 ASP A OD1 1 
ATOM   1249 O  OD2 . ASP A 1 197 ? -13.83601 -27.50111 -28.16332 1.000 61.60147  ? 197 ASP A OD2 1 
ATOM   1250 N  N   . MET A 1 198 ? -13.36308 -31.18779 -25.01221 1.000 63.24841  ? 198 MET A N   1 
ATOM   1251 C  CA  . MET A 1 198 ? -13.66760 -32.14555 -23.95688 1.000 57.15806  ? 198 MET A CA  1 
ATOM   1252 C  C   . MET A 1 198 ? -12.46798 -33.01700 -23.59480 1.000 52.63206  ? 198 MET A C   1 
ATOM   1253 O  O   . MET A 1 198 ? -12.63872 -34.19045 -23.24782 1.000 61.47642  ? 198 MET A O   1 
ATOM   1254 C  CB  . MET A 1 198 ? -14.85446 -33.01668 -24.36889 1.000 63.93039  ? 198 MET A CB  1 
ATOM   1255 C  CG  . MET A 1 198 ? -16.17135 -32.26376 -24.47902 1.000 67.87885  ? 198 MET A CG  1 
ATOM   1256 S  SD  . MET A 1 198 ? -16.47479 -31.21990 -23.04171 1.000 73.25602  ? 198 MET A SD  1 
ATOM   1257 C  CE  . MET A 1 198 ? -17.10826 -32.43537 -21.89089 1.000 67.88458  ? 198 MET A CE  1 
ATOM   1258 N  N   . THR A 1 199 ? -11.25344 -32.47026 -23.67038 1.000 55.23262  ? 199 THR A N   1 
ATOM   1259 C  CA  . THR A 1 199 ? -10.04257 -33.23161 -23.38920 1.000 50.90669  ? 199 THR A CA  1 
ATOM   1260 C  C   . THR A 1 199 ? -9.08243  -32.41363 -22.53587 1.000 53.65741  ? 199 THR A C   1 
ATOM   1261 O  O   . THR A 1 199 ? -9.10696  -31.17998 -22.54664 1.000 55.20170  ? 199 THR A O   1 
ATOM   1262 C  CB  . THR A 1 199 ? -9.30322  -33.65757 -24.67144 1.000 52.33418  ? 199 THR A CB  1 
ATOM   1263 O  OG1 . THR A 1 199 ? -8.62249  -32.52564 -25.22933 1.000 49.33551  ? 199 THR A OG1 1 
ATOM   1264 C  CG2 . THR A 1 199 ? -10.26208 -34.23762 -25.70493 1.000 45.31051  ? 199 THR A CG2 1 
ATOM   1265 N  N   . PHE A 1 200 ? -8.23218  -33.12410 -21.79652 1.000 53.29913  ? 200 PHE A N   1 
ATOM   1266 C  CA  . PHE A 1 200 ? -7.04120  -32.55586 -21.17616 1.000 50.03692  ? 200 PHE A CA  1 
ATOM   1267 C  C   . PHE A 1 200 ? -5.84668  -32.89646 -22.05993 1.000 62.76288  ? 200 PHE A C   1 
ATOM   1268 O  O   . PHE A 1 200 ? -5.54319  -34.07772 -22.25585 1.000 61.36297  ? 200 PHE A O   1 
ATOM   1269 C  CB  . PHE A 1 200 ? -6.81615  -33.11907 -19.77201 1.000 56.94105  ? 200 PHE A CB  1 
ATOM   1270 C  CG  . PHE A 1 200 ? -7.66722  -32.49499 -18.70134 1.000 55.10023  ? 200 PHE A CG  1 
ATOM   1271 C  CD1 . PHE A 1 200 ? -7.89204  -31.13087 -18.66973 1.000 65.33526  ? 200 PHE A CD1 1 
ATOM   1272 C  CD2 . PHE A 1 200 ? -8.20904  -33.27977 -17.69576 1.000 57.88153  ? 200 PHE A CD2 1 
ATOM   1273 C  CE1 . PHE A 1 200 ? -8.66253  -30.56749 -17.66736 1.000 64.21242  ? 200 PHE A CE1 1 
ATOM   1274 C  CE2 . PHE A 1 200 ? -8.97782  -32.72082 -16.69403 1.000 58.23598  ? 200 PHE A CE2 1 
ATOM   1275 C  CZ  . PHE A 1 200 ? -9.20706  -31.36407 -16.68049 1.000 53.60367  ? 200 PHE A CZ  1 
ATOM   1276 N  N   . ASN A 1 201 ? -5.17323  -31.87117 -22.59094 1.000 56.40039  ? 201 ASN A N   1 
ATOM   1277 C  CA  . ASN A 1 201 ? -3.97532  -32.06306 -23.41950 1.000 56.59745  ? 201 ASN A CA  1 
ATOM   1278 C  C   . ASN A 1 201 ? -4.23692  -33.00072 -24.59745 1.000 57.38984  ? 201 ASN A C   1 
ATOM   1279 O  O   . ASN A 1 201 ? -3.38260  -33.80943 -24.96810 1.000 53.85738  ? 201 ASN A O   1 
ATOM   1280 C  CB  . ASN A 1 201 ? -2.79782  -32.57817 -22.58682 1.000 48.29044  ? 201 ASN A CB  1 
ATOM   1281 C  CG  . ASN A 1 201 ? -2.35839  -31.59673 -21.52754 1.000 58.64623  ? 201 ASN A CG  1 
ATOM   1282 O  OD1 . ASN A 1 201 ? -1.79166  -31.97905 -20.50363 1.000 58.03309  ? 201 ASN A OD1 1 
ATOM   1283 N  ND2 . ASN A 1 201 ? -2.58868  -30.31741 -21.78220 1.000 59.14242  ? 201 ASN A ND2 1 
ATOM   1284 N  N   . ASN A 1 202 ? -5.42919  -32.89852 -25.18555 1.000 57.91745  ? 202 ASN A N   1 
ATOM   1285 C  CA  . ASN A 1 202 ? -5.84530  -33.72899 -26.31543 1.000 52.88787  ? 202 ASN A CA  1 
ATOM   1286 C  C   . ASN A 1 202 ? -5.80911  -35.21881 -25.99045 1.000 53.86184  ? 202 ASN A C   1 
ATOM   1287 O  O   . ASN A 1 202 ? -5.77670  -36.05356 -26.90041 1.000 57.17901  ? 202 ASN A O   1 
ATOM   1288 C  CB  . ASN A 1 202 ? -4.99519  -33.44581 -27.55952 1.000 52.65910  ? 202 ASN A CB  1 
ATOM   1289 C  CG  . ASN A 1 202 ? -5.52992  -32.29318 -28.38264 1.000 54.78468  ? 202 ASN A CG  1 
ATOM   1290 O  OD1 . ASN A 1 202 ? -5.97204  -31.28073 -27.84060 1.000 53.81699  ? 202 ASN A OD1 1 
ATOM   1291 N  ND2 . ASN A 1 202 ? -5.48558  -32.43842 -29.70232 1.000 47.40302  ? 202 ASN A ND2 1 
ATOM   1292 N  N   . ARG A 1 203 ? -5.81235  -35.57210 -24.70847 1.000 54.18943  ? 203 ARG A N   1 
ATOM   1293 C  CA  . ARG A 1 203 ? -5.79655  -36.96928 -24.30686 1.000 49.71201  ? 203 ARG A CA  1 
ATOM   1294 C  C   . ARG A 1 203 ? -7.20586  -37.54480 -24.31416 1.000 49.03604  ? 203 ARG A C   1 
ATOM   1295 O  O   . ARG A 1 203 ? -8.19814  -36.81864 -24.20447 1.000 58.48644  ? 203 ARG A O   1 
ATOM   1296 C  CB  . ARG A 1 203 ? -5.18521  -37.12243 -22.91437 1.000 47.45699  ? 203 ARG A CB  1 
ATOM   1297 C  CG  . ARG A 1 203 ? -3.76933  -36.58736 -22.79292 1.000 56.56751  ? 203 ARG A CG  1 
ATOM   1298 C  CD  . ARG A 1 203 ? -3.26886  -36.69925 -21.36460 1.000 60.42775  ? 203 ARG A CD  1 
ATOM   1299 N  NE  . ARG A 1 203 ? -3.28093  -38.07668 -20.88927 1.000 64.32740  ? 203 ARG A NE  1 
ATOM   1300 C  CZ  . ARG A 1 203 ? -2.25890  -38.91372 -20.99875 1.000 71.45718  ? 203 ARG A CZ  1 
ATOM   1301 N  NH1 . ARG A 1 203 ? -1.11842  -38.54228 -21.55693 1.000 74.11730  ? 203 ARG A NH1 1 
ATOM   1302 N  NH2 . ARG A 1 203 ? -2.38302  -40.15335 -20.53361 1.000 75.14979  ? 203 ARG A NH2 1 
ATOM   1303 N  N   . LYS A 1 204 ? -7.28427  -38.86290 -24.45622 1.000 60.35558  ? 204 LYS A N   1 
ATOM   1304 C  CA  . LYS A 1 204 ? -8.56479  -39.53823 -24.33363 1.000 54.53274  ? 204 LYS A CA  1 
ATOM   1305 C  C   . LYS A 1 204 ? -9.11676  -39.31917 -22.92763 1.000 55.96919  ? 204 LYS A C   1 
ATOM   1306 O  O   . LYS A 1 204 ? -8.35294  -39.33037 -21.95508 1.000 58.86556  ? 204 LYS A O   1 
ATOM   1307 C  CB  . LYS A 1 204 ? -8.41353  -41.03422 -24.61572 1.000 59.80650  ? 204 LYS A CB  1 
ATOM   1308 C  CG  . LYS A 1 204 ? -9.70034  -41.72646 -25.03794 1.000 80.37807  ? 204 LYS A CG  1 
ATOM   1309 C  CD  . LYS A 1 204 ? -9.69005  -43.20105 -24.65960 1.000 93.23588  ? 204 LYS A CD  1 
ATOM   1310 C  CE  . LYS A 1 204 ? -10.53080 -43.45945 -23.41762 1.000 95.45118  ? 204 LYS A CE  1 
ATOM   1311 N  NZ  . LYS A 1 204 ? -10.49769 -44.89062 -23.00465 1.000 88.28685  ? 204 LYS A NZ  1 
ATOM   1312 N  N   . PRO A 1 205 ? -10.42052 -39.08448 -22.78321 1.000 70.77930  ? 205 PRO A N   1 
ATOM   1313 C  CA  . PRO A 1 205 ? -10.99206 -38.90279 -21.44453 1.000 72.02410  ? 205 PRO A CA  1 
ATOM   1314 C  C   . PRO A 1 205 ? -10.74067 -40.11299 -20.55642 1.000 67.98588  ? 205 PRO A C   1 
ATOM   1315 O  O   . PRO A 1 205 ? -10.50443 -41.22777 -21.02826 1.000 69.56405  ? 205 PRO A O   1 
ATOM   1316 C  CB  . PRO A 1 205 ? -12.48707 -38.71150 -21.72097 1.000 67.28721  ? 205 PRO A CB  1 
ATOM   1317 C  CG  . PRO A 1 205 ? -12.53077 -38.14273 -23.10071 1.000 61.84209  ? 205 PRO A CG  1 
ATOM   1318 C  CD  . PRO A 1 205 ? -11.40468 -38.81013 -23.84498 1.000 68.75611  ? 205 PRO A CD  1 
ATOM   1319 N  N   . HIS A 1 206 ? -10.78427 -39.86613 -19.24535 1.000 61.61837  ? 206 HIS A N   1 
ATOM   1320 C  CA  . HIS A 1 206 ? -10.49012 -40.84846 -18.20394 1.000 68.71229  ? 206 HIS A CA  1 
ATOM   1321 C  C   . HIS A 1 206 ? -9.02409  -41.27230 -18.18355 1.000 65.02854  ? 206 HIS A C   1 
ATOM   1322 O  O   . HIS A 1 206 ? -8.68246  -42.27528 -17.54899 1.000 79.57750  ? 206 HIS A O   1 
ATOM   1323 C  CB  . HIS A 1 206 ? -11.38071 -42.09431 -18.32424 1.000 67.53513  ? 206 HIS A CB  1 
ATOM   1324 C  CG  . HIS A 1 206 ? -12.84584 -41.81541 -18.19254 1.000 74.85734  ? 206 HIS A CG  1 
ATOM   1325 N  ND1 . HIS A 1 206 ? -13.44354 -41.53516 -16.98248 1.000 78.75779  ? 206 HIS A ND1 1 
ATOM   1326 C  CD2 . HIS A 1 206 ? -13.83561 -41.78557 -19.11660 1.000 65.29849  ? 206 HIS A CD2 1 
ATOM   1327 C  CE1 . HIS A 1 206 ? -14.73772 -41.34366 -17.16657 1.000 78.60576  ? 206 HIS A CE1 1 
ATOM   1328 N  NE2 . HIS A 1 206 ? -15.00122 -41.48726 -18.45315 1.000 75.85209  ? 206 HIS A NE2 1 
ATOM   1329 N  N   . THR A 1 207 ? -8.13554  -40.53512 -18.85747 1.000 54.88193  ? 207 THR A N   1 
ATOM   1330 C  CA  . THR A 1 207 ? -6.71999  -40.89235 -18.91091 1.000 68.18439  ? 207 THR A CA  1 
ATOM   1331 C  C   . THR A 1 207 ? -5.81677  -39.78997 -18.36405 1.000 66.16106  ? 207 THR A C   1 
ATOM   1332 O  O   . THR A 1 207 ? -4.63368  -39.73316 -18.71492 1.000 61.53946  ? 207 THR A O   1 
ATOM   1333 C  CB  . THR A 1 207 ? -6.29849  -41.25352 -20.33920 1.000 60.34064  ? 207 THR A CB  1 
ATOM   1334 O  OG1 . THR A 1 207 ? -6.25730  -40.07088 -21.14912 1.000 60.25280  ? 207 THR A OG1 1 
ATOM   1335 C  CG2 . THR A 1 207 ? -7.26851  -42.25557 -20.95182 1.000 57.04829  ? 207 THR A CG2 1 
ATOM   1336 N  N   . GLY A 1 208 ? -6.34252  -38.91617 -17.51022 1.000 57.42347  ? 208 GLY A N   1 
ATOM   1337 C  CA  . GLY A 1 208 ? -5.53114  -37.91640 -16.85875 1.000 52.16192  ? 208 GLY A CA  1 
ATOM   1338 C  C   . GLY A 1 208 ? -5.42331  -36.62536 -17.64424 1.000 55.37703  ? 208 GLY A C   1 
ATOM   1339 O  O   . GLY A 1 208 ? -6.40884  -36.12452 -18.19484 1.000 60.24289  ? 208 GLY A O   1 
ATOM   1340 N  N   . PRO A 1 209 ? -4.20632  -36.06572 -17.73223 1.000 53.22709  ? 209 PRO A N   1 
ATOM   1341 C  CA  . PRO A 1 209 ? -2.92204  -36.60954 -17.26438 1.000 61.85343  ? 209 PRO A CA  1 
ATOM   1342 C  C   . PRO A 1 209 ? -2.73060  -36.55243 -15.75418 1.000 55.57953  ? 209 PRO A C   1 
ATOM   1343 O  O   . PRO A 1 209 ? -3.22804  -35.65476 -15.08079 1.000 56.01917  ? 209 PRO A O   1 
ATOM   1344 C  CB  . PRO A 1 209 ? -1.90106  -35.71325 -17.97502 1.000 47.43217  ? 209 PRO A CB  1 
ATOM   1345 C  CG  . PRO A 1 209 ? -2.59410  -34.38633 -18.05388 1.000 40.77666  ? 209 PRO A CG  1 
ATOM   1346 C  CD  . PRO A 1 209 ? -4.04121  -34.72373 -18.32065 1.000 47.14867  ? 209 PRO A CD  1 
ATOM   1347 N  N   . ASP A 1 210 ? -2.00898  -37.52212 -15.20423 1.000 54.13040  ? 210 ASP A N   1 
ATOM   1348 C  CA  . ASP A 1 210 ? -1.58959  -37.49863 -13.81310 1.000 49.72724  ? 210 ASP A CA  1 
ATOM   1349 C  C   . ASP A 1 210 ? -0.12769  -37.08153 -13.72767 1.000 47.45300  ? 210 ASP A C   1 
ATOM   1350 O  O   . ASP A 1 210 ? 0.67391   -37.37716 -14.61730 1.000 55.38607  ? 210 ASP A O   1 
ATOM   1351 C  CB  . ASP A 1 210 ? -1.77367  -38.86684 -13.15238 1.000 39.87914  ? 210 ASP A CB  1 
ATOM   1352 C  CG  . ASP A 1 210 ? -3.14380  -39.46122 -13.40534 1.000 55.98445  ? 210 ASP A CG  1 
ATOM   1353 O  OD1 . ASP A 1 210 ? -4.04147  -38.72852 -13.87178 1.000 65.49368  ? 210 ASP A OD1 1 
ATOM   1354 O  OD2 . ASP A 1 210 ? -3.32259  -40.66642 -13.13222 1.000 61.66162  ? 210 ASP A OD2 1 
ATOM   1355 N  N   . PHE A 1 211 ? 0.21149   -36.38043 -12.65015 1.000 47.04127  ? 211 PHE A N   1 
ATOM   1356 C  CA  . PHE A 1 211 ? 1.58963   -36.00261 -12.38289 1.000 48.28474  ? 211 PHE A CA  1 
ATOM   1357 C  C   . PHE A 1 211 ? 1.83249   -36.07625 -10.88386 1.000 44.76339  ? 211 PHE A C   1 
ATOM   1358 O  O   . PHE A 1 211 ? 0.89776   -36.14981 -10.08248 1.000 52.41730  ? 211 PHE A O   1 
ATOM   1359 C  CB  . PHE A 1 211 ? 1.91870   -34.61596 -12.95619 1.000 60.11655  ? 211 PHE A CB  1 
ATOM   1360 C  CG  . PHE A 1 211 ? 0.89262   -33.56501 -12.65023 1.000 52.31416  ? 211 PHE A CG  1 
ATOM   1361 C  CD1 . PHE A 1 211 ? 0.93144   -32.85767 -11.46067 1.000 59.25412  ? 211 PHE A CD1 1 
ATOM   1362 C  CD2 . PHE A 1 211 ? -0.11946  -33.29143 -13.55440 1.000 54.17194  ? 211 PHE A CD2 1 
ATOM   1363 C  CE1 . PHE A 1 211 ? -0.01458  -31.88506 -11.18794 1.000 55.94883  ? 211 PHE A CE1 1 
ATOM   1364 C  CE2 . PHE A 1 211 ? -1.06949  -32.32876 -13.28376 1.000 56.25234  ? 211 PHE A CE2 1 
ATOM   1365 C  CZ  . PHE A 1 211 ? -1.01739  -31.62499 -12.09821 1.000 59.38610  ? 211 PHE A CZ  1 
ATOM   1366 N  N   . GLU A 1 212 ? 3.10679   -36.07146 -10.50947 1.000 45.73232  ? 212 GLU A N   1 
ATOM   1367 C  CA  . GLU A 1 212 ? 3.51522   -36.41192 -9.15853  1.000 42.94143  ? 212 GLU A CA  1 
ATOM   1368 C  C   . GLU A 1 212 ? 4.29839   -35.27511 -8.52023  1.000 45.16021  ? 212 GLU A C   1 
ATOM   1369 O  O   . GLU A 1 212 ? 4.86473   -34.41407 -9.19941  1.000 47.18811  ? 212 GLU A O   1 
ATOM   1370 C  CB  . GLU A 1 212 ? 4.37238   -37.68311 -9.14545  1.000 43.47163  ? 212 GLU A CB  1 
ATOM   1371 C  CG  . GLU A 1 212 ? 3.74367   -38.86764 -9.84542  1.000 51.57292  ? 212 GLU A CG  1 
ATOM   1372 C  CD  . GLU A 1 212 ? 4.63770   -40.08623 -9.81495  1.000 62.30500  ? 212 GLU A CD  1 
ATOM   1373 O  OE1 . GLU A 1 212 ? 5.63666   -40.06880 -9.06403  1.000 57.79345  ? 212 GLU A OE1 1 
ATOM   1374 O  OE2 . GLU A 1 212 ? 4.34657   -41.05741 -10.54449 1.000 60.25155  ? 212 GLU A OE2 1 
ATOM   1375 N  N   . ALA A 1 213 ? 4.32603   -35.30036 -7.19182  1.000 40.96339  ? 213 ALA A N   1 
ATOM   1376 C  CA  . ALA A 1 213 ? 5.14640   -34.39493 -6.40314  1.000 37.42818  ? 213 ALA A CA  1 
ATOM   1377 C  C   . ALA A 1 213 ? 5.30899   -35.00180 -5.01847  1.000 42.17651  ? 213 ALA A C   1 
ATOM   1378 O  O   . ALA A 1 213 ? 4.65988   -35.99106 -4.67103  1.000 43.66485  ? 213 ALA A O   1 
ATOM   1379 C  CB  . ALA A 1 213 ? 4.53199   -32.99392 -6.32654  1.000 38.28314  ? 213 ALA A CB  1 
ATOM   1380 N  N   . THR A 1 214 ? 6.19721   -34.40279 -4.23631  1.000 39.52479  ? 214 THR A N   1 
ATOM   1381 C  CA  . THR A 1 214 ? 6.37743   -34.75466 -2.83893  1.000 39.49002  ? 214 THR A CA  1 
ATOM   1382 C  C   . THR A 1 214 ? 5.86293   -33.61107 -1.97599  1.000 44.57550  ? 214 THR A C   1 
ATOM   1383 O  O   . THR A 1 214 ? 5.91465   -32.44520 -2.37740  1.000 51.07162  ? 214 THR A O   1 
ATOM   1384 C  CB  . THR A 1 214 ? 7.85099   -35.03852 -2.52492  1.000 39.34676  ? 214 THR A CB  1 
ATOM   1385 O  OG1 . THR A 1 214 ? 8.39247   -35.90596 -3.52775  1.000 53.08896  ? 214 THR A OG1 1 
ATOM   1386 C  CG2 . THR A 1 214 ? 7.99321   -35.71054 -1.16783  1.000 44.99361  ? 214 THR A CG2 1 
ATOM   1387 N  N   . VAL A 1 215 ? 5.34155   -33.95536 -0.79770  1.000 47.68294  ? 215 VAL A N   1 
ATOM   1388 C  CA  . VAL A 1 215 ? 4.84220   -32.96048 0.14599   1.000 47.51029  ? 215 VAL A CA  1 
ATOM   1389 C  C   . VAL A 1 215 ? 5.91872   -31.90824 0.37214   1.000 40.72458  ? 215 VAL A C   1 
ATOM   1390 O  O   . VAL A 1 215 ? 7.04444   -32.22992 0.76742   1.000 55.09947  ? 215 VAL A O   1 
ATOM   1391 C  CB  . VAL A 1 215 ? 4.41539   -33.60531 1.47772   1.000 44.27449  ? 215 VAL A CB  1 
ATOM   1392 C  CG1 . VAL A 1 215 ? 3.85568   -32.55106 2.41748   1.000 51.43369  ? 215 VAL A CG1 1 
ATOM   1393 C  CG2 . VAL A 1 215 ? 3.38875   -34.69620 1.23571   1.000 47.89071  ? 215 VAL A CG2 1 
ATOM   1394 N  N   . GLY A 1 216 ? 5.58707   -30.64826 0.10126   1.000 44.62478  ? 216 GLY A N   1 
ATOM   1395 C  CA  . GLY A 1 216 ? 6.51133   -29.54944 0.24351   1.000 42.70214  ? 216 GLY A CA  1 
ATOM   1396 C  C   . GLY A 1 216 ? 7.04929   -29.00512 -1.06280  1.000 37.75606  ? 216 GLY A C   1 
ATOM   1397 O  O   . GLY A 1 216 ? 7.61863   -27.90771 -1.07047  1.000 48.40700  ? 216 GLY A O   1 
ATOM   1398 N  N   . ASP A 1 217 ? 6.88913   -29.74087 -2.16082  1.000 41.29292  ? 217 ASP A N   1 
ATOM   1399 C  CA  . ASP A 1 217 ? 7.34388   -29.25719 -3.45666  1.000 39.75828  ? 217 ASP A CA  1 
ATOM   1400 C  C   . ASP A 1 217 ? 6.56358   -28.01556 -3.86523  1.000 46.57763  ? 217 ASP A C   1 
ATOM   1401 O  O   . ASP A 1 217 ? 5.35716   -27.91206 -3.62752  1.000 42.44145  ? 217 ASP A O   1 
ATOM   1402 C  CB  . ASP A 1 217 ? 7.17774   -30.34222 -4.52174  1.000 49.39535  ? 217 ASP A CB  1 
ATOM   1403 C  CG  . ASP A 1 217 ? 8.22307   -31.43258 -4.41666  1.000 58.13984  ? 217 ASP A CG  1 
ATOM   1404 O  OD1 . ASP A 1 217 ? 9.18905   -31.26280 -3.64329  1.000 61.38215  ? 217 ASP A OD1 1 
ATOM   1405 O  OD2 . ASP A 1 217 ? 8.07895   -32.45954 -5.11510  1.000 60.62908  ? 217 ASP A OD2 1 
ATOM   1406 N  N   . ARG A 1 218 ? 7.26143   -27.06635 -4.48174  1.000 45.83933  ? 218 ARG A N   1 
ATOM   1407 C  CA  . ARG A 1 218 ? 6.62069   -25.89118 -5.06629  1.000 42.03682  ? 218 ARG A CA  1 
ATOM   1408 C  C   . ARG A 1 218 ? 6.28093   -26.23312 -6.51075  1.000 44.10386  ? 218 ARG A C   1 
ATOM   1409 O  O   . ARG A 1 218 ? 7.15880   -26.27138 -7.37655  1.000 44.47512  ? 218 ARG A O   1 
ATOM   1410 C  CB  . ARG A 1 218 ? 7.52630   -24.67044 -4.96759  1.000 37.67984  ? 218 ARG A CB  1 
ATOM   1411 C  CG  . ARG A 1 218 ? 6.91288   -23.40670 -5.53695  1.000 40.57083  ? 218 ARG A CG  1 
ATOM   1412 C  CD  . ARG A 1 218 ? 7.79606   -22.20605 -5.26562  1.000 45.70900  ? 218 ARG A CD  1 
ATOM   1413 N  NE  . ARG A 1 218 ? 7.65465   -21.72911 -3.89525  1.000 54.35239  ? 218 ARG A NE  1 
ATOM   1414 C  CZ  . ARG A 1 218 ? 6.64936   -20.97956 -3.46321  1.000 58.28409  ? 218 ARG A CZ  1 
ATOM   1415 N  NH1 . ARG A 1 218 ? 5.67835   -20.59070 -4.27398  1.000 46.56939  ? 218 ARG A NH1 1 
ATOM   1416 N  NH2 . ARG A 1 218 ? 6.61680   -20.61150 -2.18544  1.000 49.13039  ? 218 ARG A NH2 1 
ATOM   1417 N  N   . VAL A 1 219 ? 5.00208   -26.49271 -6.76950  1.000 38.06626  ? 219 VAL A N   1 
ATOM   1418 C  CA  . VAL A 1 219 ? 4.53096   -26.97594 -8.06188  1.000 40.54015  ? 219 VAL A CA  1 
ATOM   1419 C  C   . VAL A 1 219 ? 3.83361   -25.83371 -8.78654  1.000 47.81470  ? 219 VAL A C   1 
ATOM   1420 O  O   . VAL A 1 219 ? 2.96046   -25.16771 -8.21683  1.000 49.68610  ? 219 VAL A O   1 
ATOM   1421 C  CB  . VAL A 1 219 ? 3.58876   -28.18157 -7.89843  1.000 45.89661  ? 219 VAL A CB  1 
ATOM   1422 C  CG1 . VAL A 1 219 ? 3.10613   -28.67239 -9.25841  1.000 37.42360  ? 219 VAL A CG1 1 
ATOM   1423 C  CG2 . VAL A 1 219 ? 4.28396   -29.29959 -7.12812  1.000 38.57807  ? 219 VAL A CG2 1 
ATOM   1424 N  N   . GLU A 1 220 ? 4.21608   -25.61248 -10.04043 1.000 43.36161  ? 220 GLU A N   1 
ATOM   1425 C  CA  . GLU A 1 220 ? 3.61983   -24.58946 -10.88811 1.000 40.75219  ? 220 GLU A CA  1 
ATOM   1426 C  C   . GLU A 1 220 ? 2.73054   -25.25583 -11.92629 1.000 45.16466  ? 220 GLU A C   1 
ATOM   1427 O  O   . GLU A 1 220 ? 3.15611   -26.20064 -12.59874 1.000 50.04035  ? 220 GLU A O   1 
ATOM   1428 C  CB  . GLU A 1 220 ? 4.69838   -23.75470 -11.58011 1.000 42.77398  ? 220 GLU A CB  1 
ATOM   1429 C  CG  . GLU A 1 220 ? 4.16985   -22.60708 -12.42360 1.000 45.29723  ? 220 GLU A CG  1 
ATOM   1430 C  CD  . GLU A 1 220 ? 5.27723   -21.68723 -12.90456 1.000 48.21303  ? 220 GLU A CD  1 
ATOM   1431 O  OE1 . GLU A 1 220 ? 6.11848   -22.14093 -13.70819 1.000 47.93532  ? 220 GLU A OE1 1 
ATOM   1432 O  OE2 . GLU A 1 220 ? 5.31112   -20.51436 -12.47576 1.000 43.21052  ? 220 GLU A OE2 1 
ATOM   1433 N  N   . ILE A 1 221 ? 1.50138   -24.76654 -12.05405 1.000 43.91085  ? 221 ILE A N   1 
ATOM   1434 C  CA  . ILE A 1 221 ? 0.54980   -25.27046 -13.03529 1.000 46.68596  ? 221 ILE A CA  1 
ATOM   1435 C  C   . ILE A 1 221 ? 0.23085   -24.14616 -14.00892 1.000 49.13543  ? 221 ILE A C   1 
ATOM   1436 O  O   . ILE A 1 221 ? -0.06446  -23.02190 -13.58930 1.000 44.59093  ? 221 ILE A O   1 
ATOM   1437 C  CB  . ILE A 1 221 ? -0.73652  -25.79338 -12.37061 1.000 49.04435  ? 221 ILE A CB  1 
ATOM   1438 C  CG1 . ILE A 1 221 ? -0.40355  -26.64631 -11.14337 1.000 45.88300  ? 221 ILE A CG1 1 
ATOM   1439 C  CG2 . ILE A 1 221 ? -1.55701  -26.58764 -13.37053 1.000 46.95035  ? 221 ILE A CG2 1 
ATOM   1440 C  CD1 . ILE A 1 221 ? -0.15414  -28.10479 -11.45118 1.000 39.71781  ? 221 ILE A CD1 1 
ATOM   1441 N  N   . VAL A 1 222 ? 0.30072   -24.44581 -15.30203 1.000 43.70482  ? 222 VAL A N   1 
ATOM   1442 C  CA  . VAL A 1 222 ? -0.11283  -23.52493 -16.35456 1.000 43.55475  ? 222 VAL A CA  1 
ATOM   1443 C  C   . VAL A 1 222 ? -1.37501  -24.09271 -16.98593 1.000 47.17021  ? 222 VAL A C   1 
ATOM   1444 O  O   . VAL A 1 222 ? -1.37979  -25.23353 -17.46582 1.000 45.34396  ? 222 VAL A O   1 
ATOM   1445 C  CB  . VAL A 1 222 ? 0.99028   -23.31816 -17.40218 1.000 40.84118  ? 222 VAL A CB  1 
ATOM   1446 C  CG1 . VAL A 1 222 ? 0.58117   -22.23582 -18.38876 1.000 43.04860  ? 222 VAL A CG1 1 
ATOM   1447 C  CG2 . VAL A 1 222 ? 2.29741   -22.95478 -16.72219 1.000 44.10687  ? 222 VAL A CG2 1 
ATOM   1448 N  N   A MET A 1 223 ? -2.43858  -23.29260 -17.01013 0.560 47.09910  ? 223 MET A N   1 
ATOM   1449 N  N   B MET A 1 223 ? -2.44837  -23.31050 -16.96033 0.440 47.09441  ? 223 MET A N   1 
ATOM   1450 C  CA  A MET A 1 223 ? -3.75214  -23.73696 -17.46164 0.560 45.90693  ? 223 MET A CA  1 
ATOM   1451 C  CA  B MET A 1 223 ? -3.73861  -23.73204 -17.48247 0.440 45.04186  ? 223 MET A CA  1 
ATOM   1452 C  C   A MET A 1 223 ? -4.18135  -22.91620 -18.67064 0.560 48.47265  ? 223 MET A C   1 
ATOM   1453 C  C   B MET A 1 223 ? -4.08963  -22.90811 -18.70902 0.440 48.42680  ? 223 MET A C   1 
ATOM   1454 O  O   A MET A 1 223 ? -4.28406  -21.68784 -18.58455 0.560 49.09457  ? 223 MET A O   1 
ATOM   1455 O  O   B MET A 1 223 ? -4.04581  -21.67412 -18.66973 0.440 49.05072  ? 223 MET A O   1 
ATOM   1456 C  CB  A MET A 1 223 ? -4.77580  -23.61234 -16.33223 0.560 49.26901  ? 223 MET A CB  1 
ATOM   1457 C  CB  B MET A 1 223 ? -4.83684  -23.58986 -16.43108 0.440 49.27531  ? 223 MET A CB  1 
ATOM   1458 C  CG  A MET A 1 223 ? -5.70484  -24.80019 -16.20074 0.560 54.38483  ? 223 MET A CG  1 
ATOM   1459 C  CG  B MET A 1 223 ? -5.79319  -24.76215 -16.40256 0.440 54.06011  ? 223 MET A CG  1 
ATOM   1460 S  SD  A MET A 1 223 ? -7.25033  -24.54656 -17.08522 0.560 52.03580  ? 223 MET A SD  1 
ATOM   1461 S  SD  B MET A 1 223 ? -5.22039  -26.00104 -15.23660 0.440 60.86206  ? 223 MET A SD  1 
ATOM   1462 C  CE  A MET A 1 223 ? -7.12244  -25.82976 -18.32493 0.560 56.06358  ? 223 MET A CE  1 
ATOM   1463 C  CE  B MET A 1 223 ? -4.64680  -24.93234 -13.92258 0.440 51.66467  ? 223 MET A CE  1 
ATOM   1464 N  N   . ILE A 1 224 ? -4.43816  -23.59500 -19.78942 1.000 46.11990  ? 224 ILE A N   1 
ATOM   1465 C  CA  . ILE A 1 224 ? -4.88990  -22.96450 -21.02210 1.000 43.78416  ? 224 ILE A CA  1 
ATOM   1466 C  C   . ILE A 1 224 ? -6.18505  -23.64096 -21.44544 1.000 48.50852  ? 224 ILE A C   1 
ATOM   1467 O  O   . ILE A 1 224 ? -6.31143  -24.86660 -21.36001 1.000 48.14377  ? 224 ILE A O   1 
ATOM   1468 C  CB  . ILE A 1 224 ? -3.82962  -23.06403 -22.14061 1.000 50.83763  ? 224 ILE A CB  1 
ATOM   1469 C  CG1 . ILE A 1 224 ? -2.56195  -22.30234 -21.74989 1.000 50.27078  ? 224 ILE A CG1 1 
ATOM   1470 C  CG2 . ILE A 1 224 ? -4.37782  -22.53520 -23.46062 1.000 39.08997  ? 224 ILE A CG2 1 
ATOM   1471 C  CD1 . ILE A 1 224 ? -1.28869  -22.97123 -22.21329 1.000 46.03100  ? 224 ILE A CD1 1 
ATOM   1472 N  N   . THR A 1 225 ? -7.15253  -22.84580 -21.88848 1.000 47.73587  ? 225 THR A N   1 
ATOM   1473 C  CA  . THR A 1 225 ? -8.42323  -23.36345 -22.37362 1.000 43.58674  ? 225 THR A CA  1 
ATOM   1474 C  C   . THR A 1 225 ? -8.56481  -23.02593 -23.84868 1.000 45.29875  ? 225 THR A C   1 
ATOM   1475 O  O   . THR A 1 225 ? -8.28686  -21.89469 -24.26073 1.000 46.58480  ? 225 THR A O   1 
ATOM   1476 C  CB  . THR A 1 225 ? -9.59280  -22.78771 -21.57809 1.000 47.22984  ? 225 THR A CB  1 
ATOM   1477 O  OG1 . THR A 1 225 ? -9.40582  -23.08629 -20.19210 1.000 55.55250  ? 225 THR A OG1 1 
ATOM   1478 C  CG2 . THR A 1 225 ? -10.90608 -23.39443 -22.04429 1.000 42.25918  ? 225 THR A CG2 1 
ATOM   1479 N  N   . HIS A 1 226 ? -8.98820  -24.00915 -24.63768 1.000 41.83633  ? 226 HIS A N   1 
ATOM   1480 C  CA  . HIS A 1 226 ? -9.14310  -23.84211 -26.07243 1.000 43.96928  ? 226 HIS A CA  1 
ATOM   1481 C  C   . HIS A 1 226 ? -10.42531 -24.52261 -26.52117 1.000 43.58648  ? 226 HIS A C   1 
ATOM   1482 O  O   . HIS A 1 226 ? -10.91937 -25.44454 -25.86715 1.000 48.87258  ? 226 HIS A O   1 
ATOM   1483 C  CB  . HIS A 1 226 ? -7.94939  -24.42568 -26.83953 1.000 37.07932  ? 226 HIS A CB  1 
ATOM   1484 C  CG  . HIS A 1 226 ? -6.82936  -23.45525 -27.04805 1.000 37.53956  ? 226 HIS A CG  1 
ATOM   1485 N  ND1 . HIS A 1 226 ? -6.99211  -22.26356 -27.72094 1.000 42.30206  ? 226 HIS A ND1 1 
ATOM   1486 C  CD2 . HIS A 1 226 ? -5.52849  -23.50206 -26.67519 1.000 41.19959  ? 226 HIS A CD2 1 
ATOM   1487 C  CE1 . HIS A 1 226 ? -5.84016  -21.61726 -27.75223 1.000 47.41017  ? 226 HIS A CE1 1 
ATOM   1488 N  NE2 . HIS A 1 226 ? -4.93543  -22.34756 -27.12533 1.000 47.12972  ? 226 HIS A NE2 1 
ATOM   1489 N  N   . GLY A 1 227 ? -10.96128 -24.05482 -27.64398 1.000 48.47625  ? 227 GLY A N   1 
ATOM   1490 C  CA  . GLY A 1 227 ? -12.09837 -24.71098 -28.25159 1.000 45.90515  ? 227 GLY A CA  1 
ATOM   1491 C  C   . GLY A 1 227 ? -13.40073 -23.94525 -28.18107 1.000 51.98512  ? 227 GLY A C   1 
ATOM   1492 O  O   . GLY A 1 227 ? -13.45486 -22.74702 -28.47639 1.000 46.60702  ? 227 GLY A O   1 
ATOM   1493 N  N   . GLU A 1 228 ? -14.46441 -24.64449 -27.78829 1.000 50.94340  ? 228 GLU A N   1 
ATOM   1494 C  CA  . GLU A 1 228 ? -15.81337 -24.11578 -27.87529 1.000 50.94377  ? 228 GLU A CA  1 
ATOM   1495 C  C   . GLU A 1 228 ? -16.55825 -24.04386 -26.55483 1.000 51.97483  ? 228 GLU A C   1 
ATOM   1496 O  O   . GLU A 1 228 ? -17.57863 -23.34959 -26.48552 1.000 52.29572  ? 228 GLU A O   1 
ATOM   1497 C  CB  . GLU A 1 228 ? -16.64984 -24.94133 -28.86605 1.000 51.75724  ? 228 GLU A CB  1 
ATOM   1498 C  CG  . GLU A 1 228 ? -17.70790 -24.09212 -29.51803 1.000 63.54993  ? 228 GLU A CG  1 
ATOM   1499 C  CD  . GLU A 1 228 ? -17.20027 -23.38709 -30.74559 1.000 76.65440  ? 228 GLU A CD  1 
ATOM   1500 O  OE1 . GLU A 1 228 ? -16.10418 -23.73723 -31.23763 1.000 68.58017  ? 228 GLU A OE1 1 
ATOM   1501 O  OE2 . GLU A 1 228 ? -17.86275 -22.41853 -31.16829 1.000 76.24554  ? 228 GLU A OE2 1 
ATOM   1502 N  N   . TYR A 1 229 ? -16.08017 -24.70729 -25.51078 1.000 55.14771  ? 229 TYR A N   1 
ATOM   1503 C  CA  . TYR A 1 229 ? -16.82178 -24.84021 -24.27003 1.000 54.51368  ? 229 TYR A CA  1 
ATOM   1504 C  C   . TYR A 1 229 ? -16.13019 -24.09231 -23.13841 1.000 56.05849  ? 229 TYR A C   1 
ATOM   1505 O  O   . TYR A 1 229 ? -14.90578 -23.93751 -23.12544 1.000 54.25894  ? 229 TYR A O   1 
ATOM   1506 C  CB  . TYR A 1 229 ? -16.97654 -26.31612 -23.90586 1.000 53.98966  ? 229 TYR A CB  1 
ATOM   1507 C  CG  . TYR A 1 229 ? -17.49572 -27.14902 -25.05400 1.000 63.63562  ? 229 TYR A CG  1 
ATOM   1508 C  CD1 . TYR A 1 229 ? -18.70236 -26.84014 -25.66754 1.000 63.62338  ? 229 TYR A CD1 1 
ATOM   1509 C  CD2 . TYR A 1 229 ? -16.77104 -28.22945 -25.53963 1.000 64.11562  ? 229 TYR A CD2 1 
ATOM   1510 C  CE1 . TYR A 1 229 ? -19.18123 -27.59279 -26.72161 1.000 71.28989  ? 229 TYR A CE1 1 
ATOM   1511 C  CE2 . TYR A 1 229 ? -17.24222 -28.98923 -26.59453 1.000 67.97828  ? 229 TYR A CE2 1 
ATOM   1512 C  CZ  . TYR A 1 229 ? -18.44804 -28.66589 -27.18134 1.000 78.03979  ? 229 TYR A CZ  1 
ATOM   1513 O  OH  . TYR A 1 229 ? -18.92363 -29.41673 -28.23226 1.000 100.01849 ? 229 TYR A OH  1 
ATOM   1514 N  N   . TYR A 1 230 ? -16.93591 -23.61444 -22.19692 1.000 53.79966  ? 230 TYR A N   1 
ATOM   1515 C  CA  . TYR A 1 230 ? -16.43389 -23.06369 -20.94953 1.000 56.83540  ? 230 TYR A CA  1 
ATOM   1516 C  C   . TYR A 1 230 ? -16.25568 -24.18598 -19.93479 1.000 50.23494  ? 230 TYR A C   1 
ATOM   1517 O  O   . TYR A 1 230 ? -16.93937 -25.21177 -19.98814 1.000 51.89642  ? 230 TYR A O   1 
ATOM   1518 C  CB  . TYR A 1 230 ? -17.38869 -21.99944 -20.40464 1.000 50.00330  ? 230 TYR A CB  1 
ATOM   1519 C  CG  . TYR A 1 230 ? -18.43597 -22.54936 -19.46311 1.000 85.22465  ? 230 TYR A CG  1 
ATOM   1520 C  CD1 . TYR A 1 230 ? -19.58901 -23.14809 -19.95531 1.000 92.08278  ? 230 TYR A CD1 1 
ATOM   1521 C  CD2 . TYR A 1 230 ? -18.27923 -22.46237 -18.08369 1.000 81.01901  ? 230 TYR A CD2 1 
ATOM   1522 C  CE1 . TYR A 1 230 ? -20.55114 -23.65349 -19.10435 1.000 74.38337  ? 230 TYR A CE1 1 
ATOM   1523 C  CE2 . TYR A 1 230 ? -19.23708 -22.96543 -17.22454 1.000 58.47833  ? 230 TYR A CE2 1 
ATOM   1524 C  CZ  . TYR A 1 230 ? -20.37066 -23.55868 -17.74171 1.000 70.09357  ? 230 TYR A CZ  1 
ATOM   1525 O  OH  . TYR A 1 230 ? -21.33131 -24.06210 -16.89789 1.000 92.31785  ? 230 TYR A OH  1 
ATOM   1526 N  N   . HIS A 1 231 ? -15.32285 -23.98597 -19.00836 1.000 46.13494  ? 231 HIS A N   1 
ATOM   1527 C  CA  . HIS A 1 231 ? -15.00749 -24.99387 -18.00994 1.000 42.13402  ? 231 HIS A CA  1 
ATOM   1528 C  C   . HIS A 1 231 ? -14.75401 -24.31505 -16.67271 1.000 45.93042  ? 231 HIS A C   1 
ATOM   1529 O  O   . HIS A 1 231 ? -14.64727 -23.08960 -16.58037 1.000 53.95048  ? 231 HIS A O   1 
ATOM   1530 C  CB  . HIS A 1 231 ? -13.78848 -25.82641 -18.42112 1.000 45.09805  ? 231 HIS A CB  1 
ATOM   1531 C  CG  . HIS A 1 231 ? -13.83177 -26.30578 -19.83787 1.000 48.22976  ? 231 HIS A CG  1 
ATOM   1532 N  ND1 . HIS A 1 231 ? -14.43723 -27.48752 -20.20639 1.000 62.97981  ? 231 HIS A ND1 1 
ATOM   1533 C  CD2 . HIS A 1 231 ? -13.34579 -25.76079 -20.97786 1.000 52.57835  ? 231 HIS A CD2 1 
ATOM   1534 C  CE1 . HIS A 1 231 ? -14.32176 -27.65067 -21.51207 1.000 52.07901  ? 231 HIS A CE1 1 
ATOM   1535 N  NE2 . HIS A 1 231 ? -13.66292 -26.61714 -22.00405 1.000 58.89974  ? 231 HIS A NE2 1 
ATOM   1536 N  N   . THR A 1 232 ? -14.66376 -25.13193 -15.62555 1.000 43.27658  ? 232 THR A N   1 
ATOM   1537 C  CA  . THR A 1 232 ? -14.27798 -24.67555 -14.29339 1.000 50.75770  ? 232 THR A CA  1 
ATOM   1538 C  C   . THR A 1 232 ? -13.23081 -25.63860 -13.75272 1.000 48.35954  ? 232 THR A C   1 
ATOM   1539 O  O   . THR A 1 232 ? -13.55493 -26.77489 -13.39576 1.000 61.76977  ? 232 THR A O   1 
ATOM   1540 C  CB  . THR A 1 232 ? -15.48038 -24.59504 -13.35011 1.000 41.54348  ? 232 THR A CB  1 
ATOM   1541 O  OG1 . THR A 1 232 ? -16.11799 -25.87495 -13.27380 1.000 61.73813  ? 232 THR A OG1 1 
ATOM   1542 C  CG2 . THR A 1 232 ? -16.48115 -23.55459 -13.82949 1.000 49.54518  ? 232 THR A CG2 1 
ATOM   1543 N  N   . PHE A 1 233 ? -11.98068 -25.18959 -13.69459 1.000 47.73317  ? 233 PHE A N   1 
ATOM   1544 C  CA  . PHE A 1 233 ? -10.89682 -26.01862 -13.18459 1.000 42.53530  ? 233 PHE A CA  1 
ATOM   1545 C  C   . PHE A 1 233 ? -10.94075 -26.03633 -11.66174 1.000 48.48624  ? 233 PHE A C   1 
ATOM   1546 O  O   . PHE A 1 233 ? -10.85480 -24.98378 -11.01974 1.000 46.78984  ? 233 PHE A O   1 
ATOM   1547 C  CB  . PHE A 1 233 ? -9.54952  -25.49859 -13.67849 1.000 42.13874  ? 233 PHE A CB  1 
ATOM   1548 C  CG  . PHE A 1 233 ? -8.37298  -26.23441 -13.10793 1.000 50.91885  ? 233 PHE A CG  1 
ATOM   1549 C  CD1 . PHE A 1 233 ? -7.95869  -27.43529 -13.65917 1.000 49.53135  ? 233 PHE A CD1 1 
ATOM   1550 C  CD2 . PHE A 1 233 ? -7.68004  -25.72583 -12.02114 1.000 44.34403  ? 233 PHE A CD2 1 
ATOM   1551 C  CE1 . PHE A 1 233 ? -6.87730  -28.11712 -13.13568 1.000 48.63291  ? 233 PHE A CE1 1 
ATOM   1552 C  CE2 . PHE A 1 233 ? -6.59911  -26.40329 -11.49248 1.000 48.04358  ? 233 PHE A CE2 1 
ATOM   1553 C  CZ  . PHE A 1 233 ? -6.19515  -27.59880 -12.05283 1.000 49.16904  ? 233 PHE A CZ  1 
ATOM   1554 N  N   . HIS A 1 234 ? -11.06828 -27.22709 -11.08426 1.000 42.75228  ? 234 HIS A N   1 
ATOM   1555 C  CA  . HIS A 1 234 ? -11.10738 -27.39572 -9.64004  1.000 43.43298  ? 234 HIS A CA  1 
ATOM   1556 C  C   . HIS A 1 234 ? -10.00692 -28.34684 -9.19355  1.000 40.31137  ? 234 HIS A C   1 
ATOM   1557 O  O   . HIS A 1 234 ? -9.67744  -29.30529 -9.89814  1.000 46.05908  ? 234 HIS A O   1 
ATOM   1558 C  CB  . HIS A 1 234 ? -12.45990 -27.92829 -9.17555  1.000 39.70521  ? 234 HIS A CB  1 
ATOM   1559 C  CG  . HIS A 1 234 ? -12.49419 -28.26523 -7.72026  1.000 45.48772  ? 234 HIS A CG  1 
ATOM   1560 N  ND1 . HIS A 1 234 ? -12.06106 -27.39006 -6.74743  1.000 43.99963  ? 234 HIS A ND1 1 
ATOM   1561 C  CD2 . HIS A 1 234 ? -12.88402 -29.38728 -7.07189  1.000 43.78093  ? 234 HIS A CD2 1 
ATOM   1562 C  CE1 . HIS A 1 234 ? -12.19262 -27.95474 -5.56100  1.000 43.23511  ? 234 HIS A CE1 1 
ATOM   1563 N  NE2 . HIS A 1 234 ? -12.68926 -29.16647 -5.73072  1.000 50.13123  ? 234 HIS A NE2 1 
ATOM   1564 N  N   . MET A 1 235 ? -9.45131  -28.08707 -8.01173  1.000 41.64075  ? 235 MET A N   1 
ATOM   1565 C  CA  . MET A 1 235 ? -8.37048  -28.89544 -7.46280  1.000 38.53776  ? 235 MET A CA  1 
ATOM   1566 C  C   . MET A 1 235 ? -8.69227  -29.25136 -6.02010  1.000 38.43091  ? 235 MET A C   1 
ATOM   1567 O  O   . MET A 1 235 ? -8.94089  -28.36154 -5.20071  1.000 45.07560  ? 235 MET A O   1 
ATOM   1568 C  CB  . MET A 1 235 ? -7.03824  -28.15224 -7.53682  1.000 38.02493  ? 235 MET A CB  1 
ATOM   1569 C  CG  . MET A 1 235 ? -5.88159  -29.05918 -7.85135  1.000 58.51850  ? 235 MET A CG  1 
ATOM   1570 S  SD  . MET A 1 235 ? -4.50491  -28.17543 -8.58786  1.000 72.07908  ? 235 MET A SD  1 
ATOM   1571 C  CE  . MET A 1 235 ? -3.15153  -29.10721 -7.89516  1.000 53.16763  ? 235 MET A CE  1 
ATOM   1572 N  N   . HIS A 1 236 ? -8.67681  -30.54420 -5.70861  1.000 45.42905  ? 236 HIS A N   1 
ATOM   1573 C  CA  . HIS A 1 236 ? -8.91775  -30.98239 -4.34124  1.000 40.75291  ? 236 HIS A CA  1 
ATOM   1574 C  C   . HIS A 1 236 ? -7.73543  -30.63140 -3.44580  1.000 44.42504  ? 236 HIS A C   1 
ATOM   1575 O  O   . HIS A 1 236 ? -6.57499  -30.71450 -3.85784  1.000 44.09905  ? 236 HIS A O   1 
ATOM   1576 C  CB  . HIS A 1 236 ? -9.16461  -32.48981 -4.29759  1.000 44.48812  ? 236 HIS A CB  1 
ATOM   1577 C  CG  . HIS A 1 236 ? -10.50629 -32.90274 -4.81551  1.000 38.17418  ? 236 HIS A CG  1 
ATOM   1578 N  ND1 . HIS A 1 236 ? -11.17684 -34.00928 -4.34039  1.000 40.44700  ? 236 HIS A ND1 1 
ATOM   1579 C  CD2 . HIS A 1 236 ? -11.30013 -32.36309 -5.77000  1.000 45.07920  ? 236 HIS A CD2 1 
ATOM   1580 C  CE1 . HIS A 1 236 ? -12.32750 -34.13175 -4.97740  1.000 41.05097  ? 236 HIS A CE1 1 
ATOM   1581 N  NE2 . HIS A 1 236 ? -12.42648 -33.14577 -5.85057  1.000 45.45685  ? 236 HIS A NE2 1 
ATOM   1582 N  N   . GLY A 1 237 ? -8.03932  -30.23044 -2.21276  1.000 41.35685  ? 237 GLY A N   1 
ATOM   1583 C  CA  . GLY A 1 237 ? -7.03624  -30.04927 -1.18317  1.000 42.23834  ? 237 GLY A CA  1 
ATOM   1584 C  C   . GLY A 1 237 ? -6.04459  -28.92836 -1.40029  1.000 45.63627  ? 237 GLY A C   1 
ATOM   1585 O  O   . GLY A 1 237 ? -5.13374  -28.76960 -0.57937  1.000 45.04723  ? 237 GLY A O   1 
ATOM   1586 N  N   . HIS A 1 238 ? -6.17661  -28.14660 -2.46819  1.000 43.05651  ? 238 HIS A N   1 
ATOM   1587 C  CA  . HIS A 1 238 ? -5.25037  -27.05530 -2.72554  1.000 42.80046  ? 238 HIS A CA  1 
ATOM   1588 C  C   . HIS A 1 238 ? -6.02326  -25.83313 -3.19451  1.000 47.36544  ? 238 HIS A C   1 
ATOM   1589 O  O   . HIS A 1 238 ? -7.14937  -25.93274 -3.68881  1.000 46.05537  ? 238 HIS A O   1 
ATOM   1590 C  CB  . HIS A 1 238 ? -4.18646  -27.44411 -3.76031  1.000 42.04161  ? 238 HIS A CB  1 
ATOM   1591 C  CG  . HIS A 1 238 ? -3.34207  -28.60844 -3.34715  1.000 43.11538  ? 238 HIS A CG  1 
ATOM   1592 N  ND1 . HIS A 1 238 ? -3.79198  -29.91028 -3.39875  1.000 43.80921  ? 238 HIS A ND1 1 
ATOM   1593 C  CD2 . HIS A 1 238 ? -2.07855  -28.66604 -2.86403  1.000 42.61026  ? 238 HIS A CD2 1 
ATOM   1594 C  CE1 . HIS A 1 238 ? -2.84017  -30.72011 -2.97069  1.000 45.09011  ? 238 HIS A CE1 1 
ATOM   1595 N  NE2 . HIS A 1 238 ? -1.79007  -29.99024 -2.63982  1.000 46.87613  ? 238 HIS A NE2 1 
ATOM   1596 N  N   . ARG A 1 239 ? -5.39646  -24.67093 -3.02929  1.000 41.24915  ? 239 ARG A N   1 
ATOM   1597 C  CA  . ARG A 1 239 ? -6.00708  -23.40560 -3.40206  1.000 39.18211  ? 239 ARG A CA  1 
ATOM   1598 C  C   . ARG A 1 239 ? -4.91373  -22.44423 -3.84171  1.000 39.49913  ? 239 ARG A C   1 
ATOM   1599 O  O   . ARG A 1 239 ? -3.72856  -22.65602 -3.57192  1.000 48.84714  ? 239 ARG A O   1 
ATOM   1600 C  CB  . ARG A 1 239 ? -6.82095  -22.81582 -2.24349  1.000 36.77853  ? 239 ARG A CB  1 
ATOM   1601 C  CG  . ARG A 1 239 ? -5.97450  -22.27081 -1.10492  1.000 48.61312  ? 239 ARG A CG  1 
ATOM   1602 C  CD  . ARG A 1 239 ? -6.59445  -22.58424 0.24983   1.000 52.42258  ? 239 ARG A CD  1 
ATOM   1603 N  NE  . ARG A 1 239 ? -6.83805  -24.01124 0.42650   1.000 58.90770  ? 239 ARG A NE  1 
ATOM   1604 C  CZ  . ARG A 1 239 ? -5.94526  -24.87023 0.90001   1.000 52.86185  ? 239 ARG A CZ  1 
ATOM   1605 N  NH1 . ARG A 1 239 ? -4.73413  -24.47912 1.26236   1.000 51.50544  ? 239 ARG A NH1 1 
ATOM   1606 N  NH2 . ARG A 1 239 ? -6.27639  -26.15345 1.01472   1.000 43.75896  ? 239 ARG A NH2 1 
ATOM   1607 N  N   . TRP A 1 240 ? -5.32540  -21.37888 -4.52469  1.000 36.19522  ? 240 TRP A N   1 
ATOM   1608 C  CA  . TRP A 1 240 ? -4.38243  -20.39528 -5.03523  1.000 42.22567  ? 240 TRP A CA  1 
ATOM   1609 C  C   . TRP A 1 240 ? -5.07122  -19.04033 -5.12359  1.000 43.40133  ? 240 TRP A C   1 
ATOM   1610 O  O   . TRP A 1 240 ? -6.28867  -18.92404 -4.96169  1.000 44.81397  ? 240 TRP A O   1 
ATOM   1611 C  CB  . TRP A 1 240 ? -3.82110  -20.81693 -6.39880  1.000 34.46688  ? 240 TRP A CB  1 
ATOM   1612 C  CG  . TRP A 1 240 ? -4.85601  -20.88636 -7.48015  1.000 38.93634  ? 240 TRP A CG  1 
ATOM   1613 C  CD1 . TRP A 1 240 ? -5.14496  -19.92206 -8.40094  1.000 36.74821  ? 240 TRP A CD1 1 
ATOM   1614 C  CD2 . TRP A 1 240 ? -5.74224  -21.97954 -7.75278  1.000 41.32640  ? 240 TRP A CD2 1 
ATOM   1615 N  NE1 . TRP A 1 240 ? -6.15556  -20.34649 -9.23050  1.000 40.77936  ? 240 TRP A NE1 1 
ATOM   1616 C  CE2 . TRP A 1 240 ? -6.53948  -21.60647 -8.85340  1.000 42.31940  ? 240 TRP A CE2 1 
ATOM   1617 C  CE3 . TRP A 1 240 ? -5.93844  -23.23724 -7.17356  1.000 43.84123  ? 240 TRP A CE3 1 
ATOM   1618 C  CZ2 . TRP A 1 240 ? -7.51776  -22.44526 -9.38578  1.000 41.97777  ? 240 TRP A CZ2 1 
ATOM   1619 C  CZ3 . TRP A 1 240 ? -6.91029  -24.06864 -7.70411  1.000 41.04802  ? 240 TRP A CZ3 1 
ATOM   1620 C  CH2 . TRP A 1 240 ? -7.68712  -23.66882 -8.79849  1.000 39.76933  ? 240 TRP A CH2 1 
ATOM   1621 N  N   . ALA A 1 241 ? -4.27064  -18.00980 -5.38239  1.000 36.94436  ? 241 ALA A N   1 
ATOM   1622 C  CA  . ALA A 1 241 ? -4.77201  -16.64830 -5.49814  1.000 42.14485  ? 241 ALA A CA  1 
ATOM   1623 C  C   . ALA A 1 241 ? -5.14775  -16.34495 -6.94180  1.000 46.33798  ? 241 ALA A C   1 
ATOM   1624 O  O   . ALA A 1 241 ? -4.42454  -16.70352 -7.87486  1.000 53.85634  ? 241 ALA A O   1 
ATOM   1625 C  CB  . ALA A 1 241 ? -3.72893  -15.64368 -5.00720  1.000 43.40974  ? 241 ALA A CB  1 
ATOM   1626 N  N   . ASP A 1 242 ? -6.28600  -15.67773 -7.12024  1.000 41.81120  ? 242 ASP A N   1 
ATOM   1627 C  CA  . ASP A 1 242 ? -6.79083  -15.36127 -8.45633  1.000 39.95689  ? 242 ASP A CA  1 
ATOM   1628 C  C   . ASP A 1 242 ? -6.18368  -14.04047 -8.93452  1.000 42.78656  ? 242 ASP A C   1 
ATOM   1629 O  O   . ASP A 1 242 ? -6.84757  -13.00979 -9.05467  1.000 48.31185  ? 242 ASP A O   1 
ATOM   1630 C  CB  . ASP A 1 242 ? -8.31351  -15.31648 -8.44978  1.000 33.12070  ? 242 ASP A CB  1 
ATOM   1631 C  CG  . ASP A 1 242 ? -8.90328  -15.30872 -9.84617  1.000 49.34510  ? 242 ASP A CG  1 
ATOM   1632 O  OD1 . ASP A 1 242 ? -8.21654  -15.75592 -10.78939 1.000 50.66129  ? 242 ASP A OD1 1 
ATOM   1633 O  OD2 . ASP A 1 242 ? -10.05621 -14.85478 -10.00051 1.000 67.84676  ? 242 ASP A OD2 1 
ATOM   1634 N  N   . ASN A 1 243 ? -4.88558  -14.09200 -9.20936  1.000 44.29348  ? 243 ASN A N   1 
ATOM   1635 C  CA  . ASN A 1 243 ? -4.15702  -12.93865 -9.72801  1.000 42.25514  ? 243 ASN A CA  1 
ATOM   1636 C  C   . ASN A 1 243 ? -3.19273  -13.43350 -10.80257 1.000 43.79165  ? 243 ASN A C   1 
ATOM   1637 O  O   . ASN A 1 243 ? -3.34707  -14.53008 -11.35134 1.000 54.08203  ? 243 ASN A O   1 
ATOM   1638 C  CB  . ASN A 1 243 ? -3.46543  -12.17444 -8.58651  1.000 44.21746  ? 243 ASN A CB  1 
ATOM   1639 C  CG  . ASN A 1 243 ? -2.56277  -13.05797 -7.74399  1.000 43.20216  ? 243 ASN A CG  1 
ATOM   1640 O  OD1 . ASN A 1 243 ? -2.08274  -14.09698 -8.19652  1.000 50.66483  ? 243 ASN A OD1 1 
ATOM   1641 N  ND2 . ASN A 1 243 ? -2.32603  -12.64185 -6.50544  1.000 42.74266  ? 243 ASN A ND2 1 
ATOM   1642 N  N   . ARG A 1 244 ? -2.17822  -12.62069 -11.10866 1.000 44.43805  ? 244 ARG A N   1 
ATOM   1643 C  CA  . ARG A 1 244 ? -1.24898  -12.96370 -12.18151 1.000 52.56990  ? 244 ARG A CA  1 
ATOM   1644 C  C   . ARG A 1 244 ? -0.42459  -14.19920 -11.83970 1.000 49.13184  ? 244 ARG A C   1 
ATOM   1645 O  O   . ARG A 1 244 ? -0.26188  -15.09351 -12.67784 1.000 52.18204  ? 244 ARG A O   1 
ATOM   1646 C  CB  . ARG A 1 244 ? -0.32695  -11.78041 -12.47960 1.000 44.56017  ? 244 ARG A CB  1 
ATOM   1647 C  CG  . ARG A 1 244 ? 0.88378   -12.14571 -13.33060 1.000 49.91404  ? 244 ARG A CG  1 
ATOM   1648 C  CD  . ARG A 1 244 ? 1.77095   -10.94167 -13.61284 1.000 51.87912  ? 244 ARG A CD  1 
ATOM   1649 N  NE  . ARG A 1 244 ? 2.57065   -10.55270 -12.45643 1.000 49.76306  ? 244 ARG A NE  1 
ATOM   1650 C  CZ  . ARG A 1 244 ? 3.75143   -11.07617 -12.15399 1.000 48.48837  ? 244 ARG A CZ  1 
ATOM   1651 N  NH1 . ARG A 1 244 ? 4.29284   -12.03345 -12.89024 1.000 53.66405  ? 244 ARG A NH1 1 
ATOM   1652 N  NH2 . ARG A 1 244 ? 4.40362   -10.63210 -11.08351 1.000 45.14482  ? 244 ARG A NH2 1 
ATOM   1653 N  N   . THR A 1 245 ? 0.10104   -14.27100 -10.61756 1.000 55.58287  ? 245 THR A N   1 
ATOM   1654 C  CA  . THR A 1 245 ? 1.04481   -15.31662 -10.24693 1.000 48.39901  ? 245 THR A CA  1 
ATOM   1655 C  C   . THR A 1 245 ? 0.40985   -16.48561 -9.50733  1.000 45.91966  ? 245 THR A C   1 
ATOM   1656 O  O   . THR A 1 245 ? 1.04584   -17.53810 -9.39231  1.000 52.76685  ? 245 THR A O   1 
ATOM   1657 C  CB  . THR A 1 245 ? 2.16213   -14.73581 -9.37300  1.000 53.51457  ? 245 THR A CB  1 
ATOM   1658 O  OG1 . THR A 1 245 ? 1.65157   -14.47285 -8.06028  1.000 48.27542  ? 245 THR A OG1 1 
ATOM   1659 C  CG2 . THR A 1 245 ? 2.68545   -13.44333 -9.97114  1.000 51.94124  ? 245 THR A CG2 1 
ATOM   1660 N  N   . GLY A 1 246 ? -0.81316  -16.33714 -9.00614  1.000 51.13159  ? 246 GLY A N   1 
ATOM   1661 C  CA  . GLY A 1 246 ? -1.37596  -17.33054 -8.11889  1.000 42.00552  ? 246 GLY A CA  1 
ATOM   1662 C  C   . GLY A 1 246 ? -0.85967  -17.26414 -6.70050  1.000 49.03832  ? 246 GLY A C   1 
ATOM   1663 O  O   . GLY A 1 246 ? -1.24011  -18.10752 -5.87804  1.000 53.51438  ? 246 GLY A O   1 
ATOM   1664 N  N   . ILE A 1 247 ? -0.00363  -16.29391 -6.39198  1.000 44.84587  ? 247 ILE A N   1 
ATOM   1665 C  CA  . ILE A 1 247 ? 0.56992   -16.10590 -5.06785  1.000 49.68518  ? 247 ILE A CA  1 
ATOM   1666 C  C   . ILE A 1 247 ? 0.19422   -14.71772 -4.57357  1.000 53.80379  ? 247 ILE A C   1 
ATOM   1667 O  O   . ILE A 1 247 ? 0.01724   -13.78299 -5.36182  1.000 58.75680  ? 247 ILE A O   1 
ATOM   1668 C  CB  . ILE A 1 247 ? 2.10576   -16.28362 -5.07858  1.000 59.24207  ? 247 ILE A CB  1 
ATOM   1669 C  CG1 . ILE A 1 247 ? 2.50259   -17.50015 -5.91640  1.000 56.51138  ? 247 ILE A CG1 1 
ATOM   1670 C  CG2 . ILE A 1 247 ? 2.65600   -16.39525 -3.66713  1.000 71.79524  ? 247 ILE A CG2 1 
ATOM   1671 C  CD1 . ILE A 1 247 ? 3.87439   -17.37996 -6.54262  1.000 68.25529  ? 247 ILE A CD1 1 
ATOM   1672 N  N   . LEU A 1 248 ? 0.06556   -14.58841 -3.25716  1.000 48.27401  ? 248 LEU A N   1 
ATOM   1673 C  CA  . LEU A 1 248 ? -0.20150  -13.30131 -2.63715  1.000 58.40992  ? 248 LEU A CA  1 
ATOM   1674 C  C   . LEU A 1 248 ? 1.10951   -12.58014 -2.35702  1.000 61.53178  ? 248 LEU A C   1 
ATOM   1675 O  O   . LEU A 1 248 ? 2.08143   -13.18847 -1.89945  1.000 61.05399  ? 248 LEU A O   1 
ATOM   1676 C  CB  . LEU A 1 248 ? -0.99100  -13.47716 -1.33957  1.000 54.15099  ? 248 LEU A CB  1 
ATOM   1677 C  CG  . LEU A 1 248 ? -2.38464  -14.09393 -1.46441  1.000 53.89743  ? 248 LEU A CG  1 
ATOM   1678 C  CD1 . LEU A 1 248 ? -2.92089  -14.47288 -0.09214  1.000 43.24763  ? 248 LEU A CD1 1 
ATOM   1679 C  CD2 . LEU A 1 248 ? -3.33768  -13.14900 -2.18124  1.000 47.21780  ? 248 LEU A CD2 1 
ATOM   1680 N  N   . THR A 1 249 ? 1.13106   -11.27632 -2.64537  1.000 65.86635  ? 249 THR A N   1 
ATOM   1681 C  CA  . THR A 1 249 ? 2.31540   -10.47429 -2.35437  1.000 56.44306  ? 249 THR A CA  1 
ATOM   1682 C  C   . THR A 1 249 ? 2.59897   -10.44250 -0.85972  1.000 69.87069  ? 249 THR A C   1 
ATOM   1683 O  O   . THR A 1 249 ? 3.76087   -10.45385 -0.43585  1.000 78.18696  ? 249 THR A O   1 
ATOM   1684 C  CB  . THR A 1 249 ? 2.13217   -9.05296  -2.88427  1.000 65.08500  ? 249 THR A CB  1 
ATOM   1685 O  OG1 . THR A 1 249 ? 1.36381   -9.08405  -4.09361  1.000 84.41416  ? 249 THR A OG1 1 
ATOM   1686 C  CG2 . THR A 1 249 ? 3.48232   -8.41222  -3.16041  1.000 86.78358  ? 249 THR A CG2 1 
ATOM   1687 N  N   . GLY A 1 250 ? 1.54766   -10.40466 -0.04891  1.000 68.02273  ? 250 GLY A N   1 
ATOM   1688 C  CA  . GLY A 1 250 ? 1.67757   -10.35360 1.38412   1.000 55.34814  ? 250 GLY A CA  1 
ATOM   1689 C  C   . GLY A 1 250 ? 0.34256   -10.07140 2.03856   1.000 61.48336  ? 250 GLY A C   1 
ATOM   1690 O  O   . GLY A 1 250 ? -0.72238  -10.30255 1.45646   1.000 67.63595  ? 250 GLY A O   1 
ATOM   1691 N  N   . PRO A 1 251 ? 0.37528   -9.54873  3.26697   1.000 68.75603  ? 251 PRO A N   1 
ATOM   1692 C  CA  . PRO A 1 251 ? -0.87762  -9.31330  4.00365   1.000 61.37480  ? 251 PRO A CA  1 
ATOM   1693 C  C   . PRO A 1 251 ? -1.78687  -8.27052  3.37207   1.000 63.61088  ? 251 PRO A C   1 
ATOM   1694 O  O   . PRO A 1 251 ? -2.95470  -8.18009  3.77121   1.000 70.98309  ? 251 PRO A O   1 
ATOM   1695 C  CB  . PRO A 1 251 ? -0.39012  -8.85767  5.38609   1.000 60.67737  ? 251 PRO A CB  1 
ATOM   1696 C  CG  . PRO A 1 251 ? 0.99465   -8.33834  5.14465   1.000 59.74089  ? 251 PRO A CG  1 
ATOM   1697 C  CD  . PRO A 1 251 ? 1.56116   -9.21694  4.07328   1.000 58.24269  ? 251 PRO A CD  1 
ATOM   1698 N  N   . ASP A 1 252 ? -1.30515  -7.49133  2.40652   1.000 62.96736  ? 252 ASP A N   1 
ATOM   1699 C  CA  . ASP A 1 252 ? -2.10037  -6.43489  1.79624   1.000 73.50797  ? 252 ASP A CA  1 
ATOM   1700 C  C   . ASP A 1 252 ? -2.70114  -6.83345  0.45482   1.000 75.90404  ? 252 ASP A C   1 
ATOM   1701 O  O   . ASP A 1 252 ? -3.46505  -6.05227  -0.12083  1.000 74.87844  ? 252 ASP A O   1 
ATOM   1702 C  CB  . ASP A 1 252 ? -1.25196  -5.17126  1.62544   1.000 73.41300  ? 252 ASP A CB  1 
ATOM   1703 C  CG  . ASP A 1 252 ? -0.79150  -4.59715  2.95094   1.000 86.03728  ? 252 ASP A CG  1 
ATOM   1704 O  OD1 . ASP A 1 252 ? -1.64770  -4.37914  3.83508   1.000 71.63354  ? 252 ASP A OD1 1 
ATOM   1705 O  OD2 . ASP A 1 252 ? 0.42618   -4.36629  3.10953   1.000 87.29186  ? 252 ASP A OD2 1 
ATOM   1706 N  N   . ASP A 1 253 ? -2.38389  -8.01583  -0.04992  1.000 70.55960  ? 253 ASP A N   1 
ATOM   1707 C  CA  . ASP A 1 253 ? -2.90093  -8.47232  -1.33445  1.000 53.94024  ? 253 ASP A CA  1 
ATOM   1708 C  C   . ASP A 1 253 ? -4.39645  -8.74869  -1.23321  1.000 53.70569  ? 253 ASP A C   1 
ATOM   1709 O  O   . ASP A 1 253 ? -4.79400  -9.66137  -0.49585  1.000 63.00655  ? 253 ASP A O   1 
ATOM   1710 C  CB  . ASP A 1 253 ? -2.15159  -9.72771  -1.77814  1.000 65.26387  ? 253 ASP A CB  1 
ATOM   1711 C  CG  . ASP A 1 253 ? -2.20124  -9.94137  -3.27768  1.000 59.49172  ? 253 ASP A CG  1 
ATOM   1712 O  OD1 . ASP A 1 253 ? -3.28443  -9.76386  -3.87337  1.000 49.82717  ? 253 ASP A OD1 1 
ATOM   1713 O  OD2 . ASP A 1 253 ? -1.15313  -10.29293 -3.86038  1.000 66.30012  ? 253 ASP A OD2 1 
ATOM   1714 N  N   . PRO A 1 254 ? -5.25229  -8.00666  -1.93831  1.000 61.35810  ? 254 PRO A N   1 
ATOM   1715 C  CA  . PRO A 1 254 ? -6.69924  -8.22746  -1.83018  1.000 47.39700  ? 254 PRO A CA  1 
ATOM   1716 C  C   . PRO A 1 254 ? -7.23153  -9.32901  -2.72947  1.000 54.23698  ? 254 PRO A C   1 
ATOM   1717 O  O   . PRO A 1 254 ? -8.44540  -9.56598  -2.72894  1.000 54.60691  ? 254 PRO A O   1 
ATOM   1718 C  CB  . PRO A 1 254 ? -7.27358  -6.86752  -2.24309  1.000 41.87108  ? 254 PRO A CB  1 
ATOM   1719 C  CG  . PRO A 1 254 ? -6.29277  -6.36412  -3.25511  1.000 51.13156  ? 254 PRO A CG  1 
ATOM   1720 C  CD  . PRO A 1 254 ? -4.93184  -6.89539  -2.85265  1.000 54.47526  ? 254 PRO A CD  1 
ATOM   1721 N  N   . SER A 1 255 ? -6.36700  -9.99557  -3.49196  1.000 54.79844  ? 255 SER A N   1 
ATOM   1722 C  CA  . SER A 1 255 ? -6.82084  -11.00761 -4.43505  1.000 51.15667  ? 255 SER A CA  1 
ATOM   1723 C  C   . SER A 1 255 ? -7.54650  -12.13178 -3.70877  1.000 49.69170  ? 255 SER A C   1 
ATOM   1724 O  O   . SER A 1 255 ? -7.10643  -12.60141 -2.65594  1.000 56.36986  ? 255 SER A O   1 
ATOM   1725 C  CB  . SER A 1 255 ? -5.63455  -11.56979 -5.21914  1.000 48.14713  ? 255 SER A CB  1 
ATOM   1726 O  OG  . SER A 1 255 ? -4.69313  -10.55478 -5.52098  1.000 57.17109  ? 255 SER A OG  1 
ATOM   1727 N  N   . ARG A 1 256 ? -8.67445  -12.55190 -4.27268  1.000 46.62456  ? 256 ARG A N   1 
ATOM   1728 C  CA  . ARG A 1 256 ? -9.42025  -13.66192 -3.70435  1.000 48.31051  ? 256 ARG A CA  1 
ATOM   1729 C  C   . ARG A 1 256 ? -8.61514  -14.95081 -3.81028  1.000 51.88141  ? 256 ARG A C   1 
ATOM   1730 O  O   . ARG A 1 256 ? -7.83296  -15.14884 -4.74377  1.000 51.74595  ? 256 ARG A O   1 
ATOM   1731 C  CB  . ARG A 1 256 ? -10.76314 -13.83110 -4.41557  1.000 53.20702  ? 256 ARG A CB  1 
ATOM   1732 C  CG  . ARG A 1 256 ? -10.68268 -13.70479 -5.92735  1.000 57.84491  ? 256 ARG A CG  1 
ATOM   1733 C  CD  . ARG A 1 256 ? -11.89149 -14.33266 -6.60328  1.000 76.45478  ? 256 ARG A CD  1 
ATOM   1734 N  NE  . ARG A 1 256 ? -13.04055 -13.43567 -6.62981  1.000 71.55953  ? 256 ARG A NE  1 
ATOM   1735 C  CZ  . ARG A 1 256 ? -14.05383 -13.49452 -5.77658  1.000 75.91882  ? 256 ARG A CZ  1 
ATOM   1736 N  NH1 . ARG A 1 256 ? -14.08842 -14.39357 -4.80567  1.000 74.65176  ? 256 ARG A NH1 1 
ATOM   1737 N  NH2 . ARG A 1 256 ? -15.05844 -12.63146 -5.90153  1.000 56.04692  ? 256 ARG A NH2 1 
ATOM   1738 N  N   . VAL A 1 257 ? -8.80850  -15.82824 -2.83187  1.000 49.19724  ? 257 VAL A N   1 
ATOM   1739 C  CA  . VAL A 1 257 ? -8.20731  -17.15513 -2.82892  1.000 41.85323  ? 257 VAL A CA  1 
ATOM   1740 C  C   . VAL A 1 257 ? -9.27814  -18.15398 -3.24009  1.000 45.82378  ? 257 VAL A C   1 
ATOM   1741 O  O   . VAL A 1 257 ? -10.37161 -18.17565 -2.66145  1.000 51.32165  ? 257 VAL A O   1 
ATOM   1742 C  CB  . VAL A 1 257 ? -7.62146  -17.49831 -1.44952  1.000 38.43232  ? 257 VAL A CB  1 
ATOM   1743 C  CG1 . VAL A 1 257 ? -7.21542  -18.95744 -1.39431  1.000 34.56225  ? 257 VAL A CG1 1 
ATOM   1744 C  CG2 . VAL A 1 257 ? -6.43467  -16.60024 -1.14597  1.000 41.52693  ? 257 VAL A CG2 1 
ATOM   1745 N  N   . ILE A 1 258 ? -8.97604  -18.96971 -4.25090  1.000 43.12466  ? 258 ILE A N   1 
ATOM   1746 C  CA  . ILE A 1 258 ? -9.95548  -19.86516 -4.84839  1.000 37.80583  ? 258 ILE A CA  1 
ATOM   1747 C  C   . ILE A 1 258 ? -9.35598  -21.25585 -4.99963  1.000 42.30695  ? 258 ILE A C   1 
ATOM   1748 O  O   . ILE A 1 258 ? -8.14075  -21.45072 -4.92977  1.000 44.96334  ? 258 ILE A O   1 
ATOM   1749 C  CB  . ILE A 1 258 ? -10.44558 -19.35639 -6.22246  1.000 44.64334  ? 258 ILE A CB  1 
ATOM   1750 C  CG1 . ILE A 1 258 ? -9.30337  -19.40542 -7.24025  1.000 39.05888  ? 258 ILE A CG1 1 
ATOM   1751 C  CG2 . ILE A 1 258 ? -11.00960 -17.94657 -6.11212  1.000 38.92197  ? 258 ILE A CG2 1 
ATOM   1752 C  CD1 . ILE A 1 258 ? -9.68144  -18.90006 -8.61402  1.000 40.93085  ? 258 ILE A CD1 1 
ATOM   1753 N  N   . ASP A 1 259 ? -10.24345 -22.23281 -5.20168  1.000 42.43178  ? 259 ASP A N   1 
ATOM   1754 C  CA  . ASP A 1 259 ? -9.86211  -23.56291 -5.65933  1.000 45.34983  ? 259 ASP A CA  1 
ATOM   1755 C  C   . ASP A 1 259 ? -10.67700 -23.98336 -6.87714  1.000 48.14161  ? 259 ASP A C   1 
ATOM   1756 O  O   . ASP A 1 259 ? -10.61764 -25.15068 -7.28055  1.000 47.36883  ? 259 ASP A O   1 
ATOM   1757 C  CB  . ASP A 1 259 ? -10.00091 -24.59936 -4.53192  1.000 39.98632  ? 259 ASP A CB  1 
ATOM   1758 C  CG  . ASP A 1 259 ? -11.44869 -24.86237 -4.13141  1.000 42.88681  ? 259 ASP A CG  1 
ATOM   1759 O  OD1 . ASP A 1 259 ? -12.36611 -24.18002 -4.63533  1.000 43.92603  ? 259 ASP A OD1 1 
ATOM   1760 O  OD2 . ASP A 1 259 ? -11.66868 -25.76919 -3.29994  1.000 44.70092  ? 259 ASP A OD2 1 
ATOM   1761 N  N   . ASN A 1 260 ? -11.43505 -23.05866 -7.46175  1.000 43.78730  ? 260 ASN A N   1 
ATOM   1762 C  CA  . ASN A 1 260 ? -12.31244 -23.33345 -8.59322  1.000 39.51028  ? 260 ASN A CA  1 
ATOM   1763 C  C   . ASN A 1 260 ? -12.35034 -22.08132 -9.45340  1.000 44.62340  ? 260 ASN A C   1 
ATOM   1764 O  O   . ASN A 1 260 ? -12.79125 -21.02750 -8.98529  1.000 49.28558  ? 260 ASN A O   1 
ATOM   1765 C  CB  . ASN A 1 260 ? -13.71746 -23.70838 -8.11419  1.000 38.73252  ? 260 ASN A CB  1 
ATOM   1766 C  CG  . ASN A 1 260 ? -14.56890 -24.31468 -9.20974  1.000 50.21498  ? 260 ASN A CG  1 
ATOM   1767 O  OD1 . ASN A 1 260 ? -14.51511 -25.51735 -9.45979  1.000 60.60268  ? 260 ASN A OD1 1 
ATOM   1768 N  ND2 . ASN A 1 260 ? -15.36795 -23.48177 -9.86714  1.000 49.19595  ? 260 ASN A ND2 1 
ATOM   1769 N  N   . LYS A 1 261 ? -11.88365 -22.18614 -10.69567 1.000 39.36789  ? 261 LYS A N   1 
ATOM   1770 C  CA  . LYS A 1 261 ? -11.78146 -21.03396 -11.58169 1.000 44.01587  ? 261 LYS A CA  1 
ATOM   1771 C  C   . LYS A 1 261 ? -12.51301 -21.31447 -12.88372 1.000 43.31100  ? 261 LYS A C   1 
ATOM   1772 O  O   . LYS A 1 261 ? -12.23920 -22.31680 -13.55023 1.000 48.74395  ? 261 LYS A O   1 
ATOM   1773 C  CB  . LYS A 1 261 ? -10.31895 -20.68068 -11.87085 1.000 40.28184  ? 261 LYS A CB  1 
ATOM   1774 C  CG  . LYS A 1 261 ? -10.14031 -19.74694 -13.05579 1.000 48.63271  ? 261 LYS A CG  1 
ATOM   1775 C  CD  . LYS A 1 261 ? -9.11998  -18.66098 -12.76475 1.000 48.85115  ? 261 LYS A CD  1 
ATOM   1776 C  CE  . LYS A 1 261 ? -9.25675  -17.50198 -13.74034 1.000 48.06670  ? 261 LYS A CE  1 
ATOM   1777 N  NZ  . LYS A 1 261 ? -9.79734  -16.28002 -13.08066 1.000 61.46410  ? 261 LYS A NZ  1 
ATOM   1778 N  N   . ILE A 1 262 ? -13.43312 -20.42666 -13.24364 1.000 46.34707  ? 262 ILE A N   1 
ATOM   1779 C  CA  . ILE A 1 262 ? -14.12678 -20.51936 -14.52149 1.000 45.43719  ? 262 ILE A CA  1 
ATOM   1780 C  C   . ILE A 1 262 ? -13.17201 -20.09373 -15.63006 1.000 41.63020  ? 262 ILE A C   1 
ATOM   1781 O  O   . ILE A 1 262 ? -12.31330 -19.22329 -15.44408 1.000 45.61000  ? 262 ILE A O   1 
ATOM   1782 C  CB  . ILE A 1 262 ? -15.41089 -19.66431 -14.50264 1.000 50.63224  ? 262 ILE A CB  1 
ATOM   1783 C  CG1 . ILE A 1 262 ? -16.15673 -19.76321 -15.83459 1.000 60.88293  ? 262 ILE A CG1 1 
ATOM   1784 C  CG2 . ILE A 1 262 ? -15.08200 -18.21087 -14.19151 1.000 61.54091  ? 262 ILE A CG2 1 
ATOM   1785 C  CD1 . ILE A 1 262 ? -17.51518 -19.09467 -15.82326 1.000 69.74852  ? 262 ILE A CD1 1 
ATOM   1786 N  N   . THR A 1 263 ? -13.30622 -20.72325 -16.79429 1.000 45.94786  ? 263 THR A N   1 
ATOM   1787 C  CA  . THR A 1 263 ? -12.34802 -20.53008 -17.87188 1.000 50.10819  ? 263 THR A CA  1 
ATOM   1788 C  C   . THR A 1 263 ? -13.02310 -20.72965 -19.22256 1.000 51.61136  ? 263 THR A C   1 
ATOM   1789 O  O   . THR A 1 263 ? -13.93790 -21.54716 -19.35722 1.000 50.81234  ? 263 THR A O   1 
ATOM   1790 C  CB  . THR A 1 263 ? -11.15392 -21.48101 -17.70429 1.000 45.83929  ? 263 THR A CB  1 
ATOM   1791 O  OG1 . THR A 1 263 ? -10.06123 -21.04021 -18.52110 1.000 66.94570  ? 263 THR A OG1 1 
ATOM   1792 C  CG2 . THR A 1 263 ? -11.53604 -22.92198 -18.03023 1.000 48.77847  ? 263 THR A CG2 1 
ATOM   1793 N  N   . GLY A 1 264 ? -12.57205 -19.96347 -20.21463 1.000 52.90155  ? 264 GLY A N   1 
ATOM   1794 C  CA  . GLY A 1 264 ? -13.11861 -20.03013 -21.54891 1.000 40.45571  ? 264 GLY A CA  1 
ATOM   1795 C  C   . GLY A 1 264 ? -12.03338 -20.09796 -22.60318 1.000 48.90621  ? 264 GLY A C   1 
ATOM   1796 O  O   . GLY A 1 264 ? -10.84104 -19.99871 -22.30062 1.000 51.31284  ? 264 GLY A O   1 
ATOM   1797 N  N   . PRO A 1 265 ? -12.43075 -20.28066 -23.86186 1.000 48.59221  ? 265 PRO A N   1 
ATOM   1798 C  CA  . PRO A 1 265 ? -11.44936 -20.40187 -24.94825 1.000 39.53679  ? 265 PRO A CA  1 
ATOM   1799 C  C   . PRO A 1 265 ? -10.42865 -19.27159 -24.94490 1.000 50.28350  ? 265 PRO A C   1 
ATOM   1800 O  O   . PRO A 1 265 ? -10.77981 -18.09078 -24.86414 1.000 48.20083  ? 265 PRO A O   1 
ATOM   1801 C  CB  . PRO A 1 265 ? -12.31896 -20.36749 -26.20770 1.000 43.04618  ? 265 PRO A CB  1 
ATOM   1802 C  CG  . PRO A 1 265 ? -13.65643 -20.87019 -25.77336 1.000 47.93445  ? 265 PRO A CG  1 
ATOM   1803 C  CD  . PRO A 1 265 ? -13.77931 -20.69913 -24.28033 1.000 43.39779  ? 265 PRO A CD  1 
ATOM   1804 N  N   . ALA A 1 266 ? -9.15117  -19.65566 -25.02415 1.000 43.83918  ? 266 ALA A N   1 
ATOM   1805 C  CA  . ALA A 1 266 ? -7.97353  -18.78749 -25.03421 1.000 46.00689  ? 266 ALA A CA  1 
ATOM   1806 C  C   . ALA A 1 266 ? -7.69011  -18.13284 -23.69030 1.000 46.97351  ? 266 ALA A C   1 
ATOM   1807 O  O   . ALA A 1 266 ? -6.84966  -17.22630 -23.62019 1.000 52.22294  ? 266 ALA A O   1 
ATOM   1808 C  CB  . ALA A 1 266 ? -8.05741  -17.69780 -26.10616 1.000 42.86463  ? 266 ALA A CB  1 
ATOM   1809 N  N   . ASP A 1 267 ? -8.35927  -18.55284 -22.62246 1.000 46.32148  ? 267 ASP A N   1 
ATOM   1810 C  CA  . ASP A 1 267 ? -7.97337  -18.11519 -21.29130 1.000 48.69459  ? 267 ASP A CA  1 
ATOM   1811 C  C   . ASP A 1 267 ? -6.71540  -18.85385 -20.86101 1.000 51.00935  ? 267 ASP A C   1 
ATOM   1812 O  O   . ASP A 1 267 ? -6.59845  -20.06986 -21.03966 1.000 50.68139  ? 267 ASP A O   1 
ATOM   1813 C  CB  . ASP A 1 267 ? -9.09678  -18.36333 -20.28558 1.000 47.76341  ? 267 ASP A CB  1 
ATOM   1814 C  CG  . ASP A 1 267 ? -10.01935 -17.16920 -20.13474 1.000 66.92249  ? 267 ASP A CG  1 
ATOM   1815 O  OD1 . ASP A 1 267 ? -9.57918  -16.03281 -20.41200 1.000 61.30148  ? 267 ASP A OD1 1 
ATOM   1816 O  OD2 . ASP A 1 267 ? -11.18762 -17.36787 -19.73877 1.000 72.32977  ? 267 ASP A OD2 1 
ATOM   1817 N  N   . SER A 1 268 ? -5.76350  -18.11007 -20.30758 1.000 44.67413  ? 268 SER A N   1 
ATOM   1818 C  CA  . SER A 1 268 ? -4.52627  -18.68728 -19.80190 1.000 43.61317  ? 268 SER A CA  1 
ATOM   1819 C  C   . SER A 1 268 ? -4.25909  -18.11527 -18.42075 1.000 39.96871  ? 268 SER A C   1 
ATOM   1820 O  O   . SER A 1 268 ? -4.12967  -16.89679 -18.26445 1.000 53.13554  ? 268 SER A O   1 
ATOM   1821 C  CB  . SER A 1 268 ? -3.34869  -18.40591 -20.74091 1.000 39.84912  ? 268 SER A CB  1 
ATOM   1822 O  OG  . SER A 1 268 ? -3.23758  -17.02283 -21.02633 1.000 49.28391  ? 268 SER A OG  1 
ATOM   1823 N  N   . PHE A 1 269 ? -4.19326  -18.98850 -17.42200 1.000 40.39703  ? 269 PHE A N   1 
ATOM   1824 C  CA  . PHE A 1 269 ? -3.78749  -18.58950 -16.08621 1.000 47.57730  ? 269 PHE A CA  1 
ATOM   1825 C  C   . PHE A 1 269 ? -2.84524  -19.64430 -15.53037 1.000 49.65416  ? 269 PHE A C   1 
ATOM   1826 O  O   . PHE A 1 269 ? -2.71506  -20.74681 -16.07024 1.000 42.23526  ? 269 PHE A O   1 
ATOM   1827 C  CB  . PHE A 1 269 ? -4.98952  -18.37998 -15.15189 1.000 44.92721  ? 269 PHE A CB  1 
ATOM   1828 C  CG  . PHE A 1 269 ? -5.72446  -19.64463 -14.79843 1.000 44.98198  ? 269 PHE A CG  1 
ATOM   1829 C  CD1 . PHE A 1 269 ? -6.62065  -20.21635 -15.68612 1.000 44.20792  ? 269 PHE A CD1 1 
ATOM   1830 C  CD2 . PHE A 1 269 ? -5.52678  -20.25390 -13.56867 1.000 48.05149  ? 269 PHE A CD2 1 
ATOM   1831 C  CE1 . PHE A 1 269 ? -7.30474  -21.37374 -15.35554 1.000 45.33027  ? 269 PHE A CE1 1 
ATOM   1832 C  CE2 . PHE A 1 269 ? -6.20365  -21.41257 -13.23387 1.000 46.85058  ? 269 PHE A CE2 1 
ATOM   1833 C  CZ  . PHE A 1 269 ? -7.09292  -21.97365 -14.12888 1.000 47.92755  ? 269 PHE A CZ  1 
ATOM   1834 N  N   . GLY A 1 270 ? -2.17329  -19.28490 -14.44165 1.000 41.45090  ? 270 GLY A N   1 
ATOM   1835 C  CA  . GLY A 1 270 ? -1.25776  -20.19377 -13.78852 1.000 42.12064  ? 270 GLY A CA  1 
ATOM   1836 C  C   . GLY A 1 270 ? -1.13401  -19.83266 -12.32738 1.000 42.68705  ? 270 GLY A C   1 
ATOM   1837 O  O   . GLY A 1 270 ? -1.53564  -18.75051 -11.89358 1.000 50.71997  ? 270 GLY A O   1 
ATOM   1838 N  N   . PHE A 1 271 ? -0.56982  -20.76202 -11.56648 1.000 41.94037  ? 271 PHE A N   1 
ATOM   1839 C  CA  . PHE A 1 271 ? -0.39340  -20.55599 -10.13812 1.000 44.64140  ? 271 PHE A CA  1 
ATOM   1840 C  C   . PHE A 1 271 ? 0.68459   -21.50463 -9.64107  1.000 52.45871  ? 271 PHE A C   1 
ATOM   1841 O  O   . PHE A 1 271 ? 1.12490   -22.41141 -10.35289 1.000 40.01550  ? 271 PHE A O   1 
ATOM   1842 C  CB  . PHE A 1 271 ? -1.70517  -20.77009 -9.37532  1.000 42.00575  ? 271 PHE A CB  1 
ATOM   1843 C  CG  . PHE A 1 271 ? -2.32889  -22.11874 -9.60444  1.000 40.95246  ? 271 PHE A CG  1 
ATOM   1844 C  CD1 . PHE A 1 271 ? -2.00734  -23.19574 -8.79272  1.000 42.60161  ? 271 PHE A CD1 1 
ATOM   1845 C  CD2 . PHE A 1 271 ? -3.24101  -22.30872 -10.62886 1.000 39.36946  ? 271 PHE A CD2 1 
ATOM   1846 C  CE1 . PHE A 1 271 ? -2.58207  -24.43706 -9.00152  1.000 40.01244  ? 271 PHE A CE1 1 
ATOM   1847 C  CE2 . PHE A 1 271 ? -3.81936  -23.54566 -10.84109 1.000 40.84163  ? 271 PHE A CE2 1 
ATOM   1848 C  CZ  . PHE A 1 271 ? -3.48877  -24.61150 -10.02798 1.000 42.39921  ? 271 PHE A CZ  1 
ATOM   1849 N  N   . GLN A 1 272 ? 1.10483   -21.27797 -8.40314  1.000 43.26196  ? 272 GLN A N   1 
ATOM   1850 C  CA  . GLN A 1 272 ? 2.00721   -22.17559 -7.70708  1.000 40.43133  ? 272 GLN A CA  1 
ATOM   1851 C  C   . GLN A 1 272 ? 1.35934   -22.62128 -6.40580  1.000 45.64259  ? 272 GLN A C   1 
ATOM   1852 O  O   . GLN A 1 272 ? 0.58769   -21.88013 -5.79005  1.000 48.33226  ? 272 GLN A O   1 
ATOM   1853 C  CB  . GLN A 1 272 ? 3.35807   -21.51193 -7.42930  1.000 36.71581  ? 272 GLN A CB  1 
ATOM   1854 C  CG  . GLN A 1 272 ? 4.13880   -21.17241 -8.68529  1.000 44.47246  ? 272 GLN A CG  1 
ATOM   1855 C  CD  . GLN A 1 272 ? 5.47235   -20.52598 -8.38194  1.000 49.87046  ? 272 GLN A CD  1 
ATOM   1856 O  OE1 . GLN A 1 272 ? 5.89314   -20.45801 -7.22718  1.000 53.21700  ? 272 GLN A OE1 1 
ATOM   1857 N  NE2 . GLN A 1 272 ? 6.14819   -20.04800 -9.42061  1.000 53.63348  ? 272 GLN A NE2 1 
ATOM   1858 N  N   . ILE A 1 273 ? 1.66620   -23.84999 -6.00278  1.000 43.52908  ? 273 ILE A N   1 
ATOM   1859 C  CA  . ILE A 1 273 ? 1.15069   -24.41791 -4.76637  1.000 41.69430  ? 273 ILE A CA  1 
ATOM   1860 C  C   . ILE A 1 273 ? 2.26551   -25.19827 -4.09164  1.000 45.80114  ? 273 ILE A C   1 
ATOM   1861 O  O   . ILE A 1 273 ? 3.16110   -25.73617 -4.74970  1.000 49.51965  ? 273 ILE A O   1 
ATOM   1862 C  CB  . ILE A 1 273 ? -0.05653  -25.34443 -5.00797  1.000 45.06251  ? 273 ILE A CB  1 
ATOM   1863 C  CG1 . ILE A 1 273 ? 0.28289   -26.35160 -6.10317  1.000 42.87715  ? 273 ILE A CG1 1 
ATOM   1864 C  CG2 . ILE A 1 273 ? -1.29536  -24.54127 -5.37131  1.000 46.79897  ? 273 ILE A CG2 1 
ATOM   1865 C  CD1 . ILE A 1 273 ? -0.63732  -27.52048 -6.14178  1.000 44.43402  ? 273 ILE A CD1 1 
ATOM   1866 N  N   . ILE A 1 274 ? 2.20499   -25.25998 -2.76759  1.000 38.55238  ? 274 ILE A N   1 
ATOM   1867 C  CA  . ILE A 1 274 ? 3.03958   -26.17474 -2.00191  1.000 43.48930  ? 274 ILE A CA  1 
ATOM   1868 C  C   . ILE A 1 274 ? 2.27735   -27.49123 -1.91945  1.000 45.42806  ? 274 ILE A C   1 
ATOM   1869 O  O   . ILE A 1 274 ? 1.21032   -27.56128 -1.30390  1.000 44.55657  ? 274 ILE A O   1 
ATOM   1870 C  CB  . ILE A 1 274 ? 3.36707   -25.62020 -0.61141  1.000 44.31073  ? 274 ILE A CB  1 
ATOM   1871 C  CG1 . ILE A 1 274 ? 4.01861   -24.23932 -0.72397  1.000 44.36825  ? 274 ILE A CG1 1 
ATOM   1872 C  CG2 . ILE A 1 274 ? 4.28285   -26.57336 0.13301   1.000 35.60512  ? 274 ILE A CG2 1 
ATOM   1873 C  CD1 . ILE A 1 274 ? 5.13228   -24.16318 -1.74881  1.000 40.12179  ? 274 ILE A CD1 1 
ATOM   1874 N  N   . ALA A 1 275 ? 2.81053   -28.52678 -2.56512  1.000 39.26535  ? 275 ALA A N   1 
ATOM   1875 C  CA  . ALA A 1 275 ? 2.12184   -29.80913 -2.63915  1.000 40.43812  ? 275 ALA A CA  1 
ATOM   1876 C  C   . ALA A 1 275 ? 1.85414   -30.35601 -1.24282  1.000 44.13728  ? 275 ALA A C   1 
ATOM   1877 O  O   . ALA A 1 275 ? 2.77576   -30.49985 -0.43400  1.000 44.91307  ? 275 ALA A O   1 
ATOM   1878 C  CB  . ALA A 1 275 ? 2.94933   -30.80209 -3.45378  1.000 39.15790  ? 275 ALA A CB  1 
ATOM   1879 N  N   . GLY A 1 276 ? 0.58587   -30.64599 -0.95915  1.000 39.12533  ? 276 GLY A N   1 
ATOM   1880 C  CA  . GLY A 1 276 ? 0.20157   -31.20339 0.32090   1.000 43.21256  ? 276 GLY A CA  1 
ATOM   1881 C  C   . GLY A 1 276 ? 0.24801   -30.24684 1.48959   1.000 52.95198  ? 276 GLY A C   1 
ATOM   1882 O  O   . GLY A 1 276 ? 0.15524   -30.69497 2.63684   1.000 51.59738  ? 276 GLY A O   1 
ATOM   1883 N  N   . GLU A 1 277 ? 0.38275   -28.94527 1.23992   1.000 42.74737  ? 277 GLU A N   1 
ATOM   1884 C  CA  . GLU A 1 277 ? 0.49588   -27.97630 2.32370   1.000 49.56337  ? 277 GLU A CA  1 
ATOM   1885 C  C   . GLU A 1 277 ? -0.78568  -27.93718 3.14437   1.000 52.59574  ? 277 GLU A C   1 
ATOM   1886 O  O   . GLU A 1 277 ? -1.86182  -27.63282 2.62067   1.000 45.18551  ? 277 GLU A O   1 
ATOM   1887 C  CB  . GLU A 1 277 ? 0.80667   -26.59195 1.76105   1.000 45.41137  ? 277 GLU A CB  1 
ATOM   1888 C  CG  . GLU A 1 277 ? 1.17042   -25.56617 2.81858   1.000 45.33770  ? 277 GLU A CG  1 
ATOM   1889 C  CD  . GLU A 1 277 ? 1.45236   -24.19858 2.23103   1.000 52.40754  ? 277 GLU A CD  1 
ATOM   1890 O  OE1 . GLU A 1 277 ? 0.74823   -23.80124 1.27839   1.000 59.38558  ? 277 GLU A OE1 1 
ATOM   1891 O  OE2 . GLU A 1 277 ? 2.38086   -23.52151 2.72025   1.000 54.57388  ? 277 GLU A OE2 1 
ATOM   1892 N  N   . GLY A 1 278 ? -0.66565  -28.24227 4.43478   1.000 43.75947  ? 278 GLY A N   1 
ATOM   1893 C  CA  . GLY A 1 278 ? -1.80735  -28.27407 5.32035   1.000 42.86406  ? 278 GLY A CA  1 
ATOM   1894 C  C   . GLY A 1 278 ? -2.74120  -29.44576 5.12944   1.000 45.23503  ? 278 GLY A C   1 
ATOM   1895 O  O   . GLY A 1 278 ? -3.68045  -29.60016 5.91654   1.000 54.52552  ? 278 GLY A O   1 
ATOM   1896 N  N   . VAL A 1 279 ? -2.51701  -30.27983 4.11390   1.000 47.96315  ? 279 VAL A N   1 
ATOM   1897 C  CA  . VAL A 1 279 ? -3.40636  -31.40687 3.84392   1.000 49.42996  ? 279 VAL A CA  1 
ATOM   1898 C  C   . VAL A 1 279 ? -2.68534  -32.74356 3.79012   1.000 48.42449  ? 279 VAL A C   1 
ATOM   1899 O  O   . VAL A 1 279 ? -3.34075  -33.79402 3.92091   1.000 51.34630  ? 279 VAL A O   1 
ATOM   1900 C  CB  . VAL A 1 279 ? -4.19230  -31.17184 2.53400   1.000 46.06128  ? 279 VAL A CB  1 
ATOM   1901 C  CG1 . VAL A 1 279 ? -5.09346  -29.95580 2.66340   1.000 42.17892  ? 279 VAL A CG1 1 
ATOM   1902 C  CG2 . VAL A 1 279 ? -3.24048  -31.00446 1.36154   1.000 41.30787  ? 279 VAL A CG2 1 
ATOM   1903 N  N   . GLY A 1 280 ? -1.36922  -32.78418 3.59799   1.000 48.72985  ? 280 GLY A N   1 
ATOM   1904 C  CA  . GLY A 1 280 ? -0.64654  -34.03909 3.57100   1.000 43.80628  ? 280 GLY A CA  1 
ATOM   1905 C  C   . GLY A 1 280 ? -0.63708  -34.69124 2.20383   1.000 49.64034  ? 280 GLY A C   1 
ATOM   1906 O  O   . GLY A 1 280 ? -1.14505  -34.16754 1.20797   1.000 52.01205  ? 280 GLY A O   1 
ATOM   1907 N  N   . ALA A 1 281 ? -0.03529  -35.87574 2.16402   1.000 55.93950  ? 281 ALA A N   1 
ATOM   1908 C  CA  . ALA A 1 281 ? 0.07541   -36.62916 0.92714   1.000 47.59884  ? 281 ALA A CA  1 
ATOM   1909 C  C   . ALA A 1 281 ? -1.25049  -37.30217 0.58669   1.000 46.91956  ? 281 ALA A C   1 
ATOM   1910 O  O   . ALA A 1 281 ? -2.14410  -37.43941 1.42691   1.000 49.66426  ? 281 ALA A O   1 
ATOM   1911 C  CB  . ALA A 1 281 ? 1.18420   -37.67552 1.03388   1.000 49.77728  ? 281 ALA A CB  1 
ATOM   1912 N  N   . GLY A 1 282 ? -1.36858  -37.72116 -0.66087  1.000 44.43311  ? 282 GLY A N   1 
ATOM   1913 C  CA  . GLY A 1 282 ? -2.56382  -38.40303 -1.11920  1.000 42.76530  ? 282 GLY A CA  1 
ATOM   1914 C  C   . GLY A 1 282 ? -2.76086  -38.21730 -2.60763  1.000 48.21257  ? 282 GLY A C   1 
ATOM   1915 O  O   . GLY A 1 282 ? -2.05412  -37.46084 -3.27082  1.000 47.05843  ? 282 GLY A O   1 
ATOM   1916 N  N   . ALA A 1 283 ? -3.74853  -38.94227 -3.13202  1.000 47.77034  ? 283 ALA A N   1 
ATOM   1917 C  CA  . ALA A 1 283 ? -4.14231  -38.82873 -4.53566  1.000 44.81429  ? 283 ALA A CA  1 
ATOM   1918 C  C   . ALA A 1 283 ? -5.16644  -37.70612 -4.63858  1.000 50.07580  ? 283 ALA A C   1 
ATOM   1919 O  O   . ALA A 1 283 ? -6.37588  -37.92406 -4.55276  1.000 57.98032  ? 283 ALA A O   1 
ATOM   1920 C  CB  . ALA A 1 283 ? -4.69225  -40.15057 -5.05547  1.000 39.92486  ? 283 ALA A CB  1 
ATOM   1921 N  N   . TRP A 1 284 ? -4.67066  -36.48494 -4.81855  1.000 50.80761  ? 284 TRP A N   1 
ATOM   1922 C  CA  . TRP A 1 284 ? -5.51236  -35.29566 -4.89060  1.000 37.32716  ? 284 TRP A CA  1 
ATOM   1923 C  C   . TRP A 1 284 ? -5.96012  -35.10486 -6.33313  1.000 41.58079  ? 284 TRP A C   1 
ATOM   1924 O  O   . TRP A 1 284 ? -5.15626  -34.74038 -7.19553  1.000 53.46422  ? 284 TRP A O   1 
ATOM   1925 C  CB  . TRP A 1 284 ? -4.74951  -34.07377 -4.38952  1.000 41.60942  ? 284 TRP A CB  1 
ATOM   1926 C  CG  . TRP A 1 284 ? -4.31074  -34.19722 -2.97153  1.000 50.77233  ? 284 TRP A CG  1 
ATOM   1927 C  CD1 . TRP A 1 284 ? -3.05384  -34.48230 -2.52478  1.000 49.10451  ? 284 TRP A CD1 1 
ATOM   1928 C  CD2 . TRP A 1 284 ? -5.12729  -34.04452 -1.80626  1.000 44.76967  ? 284 TRP A CD2 1 
ATOM   1929 N  NE1 . TRP A 1 284 ? -3.03636  -34.51502 -1.15167  1.000 49.29924  ? 284 TRP A NE1 1 
ATOM   1930 C  CE2 . TRP A 1 284 ? -4.29737  -34.24911 -0.68599  1.000 45.44160  ? 284 TRP A CE2 1 
ATOM   1931 C  CE3 . TRP A 1 284 ? -6.47966  -33.75329 -1.60123  1.000 43.80648  ? 284 TRP A CE3 1 
ATOM   1932 C  CZ2 . TRP A 1 284 ? -4.77491  -34.17241 0.62004   1.000 41.47978  ? 284 TRP A CZ2 1 
ATOM   1933 C  CZ3 . TRP A 1 284 ? -6.95178  -33.67808 -0.30571  1.000 47.08294  ? 284 TRP A CZ3 1 
ATOM   1934 C  CH2 . TRP A 1 284 ? -6.10167  -33.88616 0.78915   1.000 52.33901  ? 284 TRP A CH2 1 
ATOM   1935 N  N   . MET A 1 285 ? -7.23845  -35.34250 -6.59903  1.000 46.92428  ? 285 MET A N   1 
ATOM   1936 C  CA  . MET A 1 285 ? -7.72464  -35.26102 -7.96536  1.000 48.54194  ? 285 MET A CA  1 
ATOM   1937 C  C   . MET A 1 285 ? -8.04463  -33.82110 -8.34504  1.000 47.51211  ? 285 MET A C   1 
ATOM   1938 O  O   . MET A 1 285 ? -8.39754  -32.99162 -7.50185  1.000 47.28869  ? 285 MET A O   1 
ATOM   1939 C  CB  . MET A 1 285 ? -8.96035  -36.14270 -8.15878  1.000 48.02461  ? 285 MET A CB  1 
ATOM   1940 C  CG  . MET A 1 285 ? -10.25173 -35.56697 -7.60739  1.000 54.84101  ? 285 MET A CG  1 
ATOM   1941 S  SD  . MET A 1 285 ? -11.44718 -36.84776 -7.16479  1.000 73.31038  ? 285 MET A SD  1 
ATOM   1942 C  CE  . MET A 1 285 ? -11.90469 -37.46656 -8.77857  1.000 62.98125  ? 285 MET A CE  1 
ATOM   1943 N  N   . TYR A 1 286 ? -7.88386  -33.52691 -9.63156  1.000 42.93784  ? 286 TYR A N   1 
ATOM   1944 C  CA  . TYR A 1 286 ? -8.32526  -32.27691 -10.22594 1.000 36.62527  ? 286 TYR A CA  1 
ATOM   1945 C  C   . TYR A 1 286 ? -9.24014  -32.60802 -11.39274 1.000 45.22231  ? 286 TYR A C   1 
ATOM   1946 O  O   . TYR A 1 286 ? -9.09317  -33.65123 -12.03584 1.000 49.78714  ? 286 TYR A O   1 
ATOM   1947 C  CB  . TYR A 1 286 ? -7.14631  -31.41719 -10.70668 1.000 41.74000  ? 286 TYR A CB  1 
ATOM   1948 C  CG  . TYR A 1 286 ? -6.44418  -31.97328 -11.92540 1.000 46.46130  ? 286 TYR A CG  1 
ATOM   1949 C  CD1 . TYR A 1 286 ? -5.39117  -32.86798 -11.79421 1.000 37.64123  ? 286 TYR A CD1 1 
ATOM   1950 C  CD2 . TYR A 1 286 ? -6.83329  -31.60238 -13.20741 1.000 46.97616  ? 286 TYR A CD2 1 
ATOM   1951 C  CE1 . TYR A 1 286 ? -4.74787  -33.37846 -12.90280 1.000 44.69029  ? 286 TYR A CE1 1 
ATOM   1952 C  CE2 . TYR A 1 286 ? -6.20014  -32.11186 -14.32072 1.000 48.13946  ? 286 TYR A CE2 1 
ATOM   1953 C  CZ  . TYR A 1 286 ? -5.15778  -32.99969 -14.16346 1.000 51.62324  ? 286 TYR A CZ  1 
ATOM   1954 O  OH  . TYR A 1 286 ? -4.52078  -33.50729 -15.27270 1.000 53.82061  ? 286 TYR A OH  1 
ATOM   1955 N  N   . HIS A 1 287 ? -10.18279 -31.71408 -11.66852 1.000 41.39276  ? 287 HIS A N   1 
ATOM   1956 C  CA  . HIS A 1 287 ? -11.15194 -31.98611 -12.71883 1.000 40.54556  ? 287 HIS A CA  1 
ATOM   1957 C  C   . HIS A 1 287 ? -11.88982 -30.70356 -13.05678 1.000 44.78642  ? 287 HIS A C   1 
ATOM   1958 O  O   . HIS A 1 287 ? -11.91988 -29.75546 -12.26689 1.000 46.77864  ? 287 HIS A O   1 
ATOM   1959 C  CB  . HIS A 1 287 ? -12.14970 -33.06840 -12.29416 1.000 37.11205  ? 287 HIS A CB  1 
ATOM   1960 C  CG  . HIS A 1 287 ? -12.83766 -32.77695 -10.99686 1.000 44.38439  ? 287 HIS A CG  1 
ATOM   1961 N  ND1 . HIS A 1 287 ? -14.01850 -32.06995 -10.92362 1.000 48.63079  ? 287 HIS A ND1 1 
ATOM   1962 C  CD2 . HIS A 1 287 ? -12.50949 -33.09343 -9.72182  1.000 45.06635  ? 287 HIS A CD2 1 
ATOM   1963 C  CE1 . HIS A 1 287 ? -14.38964 -31.96566 -9.66005  1.000 47.05639  ? 287 HIS A CE1 1 
ATOM   1964 N  NE2 . HIS A 1 287 ? -13.49097 -32.57780 -8.91039  1.000 52.99182  ? 287 HIS A NE2 1 
ATOM   1965 N  N   . CYS A 1 288 ? -12.47871 -30.68552 -14.24731 1.000 43.05143  ? 288 CYS A N   1 
ATOM   1966 C  CA  . CYS A 1 288 ? -13.50043 -29.69504 -14.53629 1.000 45.73448  ? 288 CYS A CA  1 
ATOM   1967 C  C   . CYS A 1 288 ? -14.72360 -29.98387 -13.68104 1.000 52.77696  ? 288 CYS A C   1 
ATOM   1968 O  O   . CYS A 1 288 ? -15.13064 -31.13848 -13.52518 1.000 55.59237  ? 288 CYS A O   1 
ATOM   1969 C  CB  . CYS A 1 288 ? -13.87828 -29.71307 -16.01363 1.000 42.65997  ? 288 CYS A CB  1 
ATOM   1970 S  SG  . CYS A 1 288 ? -15.20435 -28.55621 -16.40927 1.000 58.03978  ? 288 CYS A SG  1 
ATOM   1971 N  N   . HIS A 1 289 ? -15.30743 -28.93515 -13.11188 1.000 44.51674  ? 289 HIS A N   1 
ATOM   1972 C  CA  . HIS A 1 289 ? -16.42385 -29.11876 -12.19998 1.000 47.20669  ? 289 HIS A CA  1 
ATOM   1973 C  C   . HIS A 1 289 ? -17.78069 -28.97472 -12.87323 1.000 48.87347  ? 289 HIS A C   1 
ATOM   1974 O  O   . HIS A 1 289 ? -18.80530 -29.08271 -12.19218 1.000 52.18297  ? 289 HIS A O   1 
ATOM   1975 C  CB  . HIS A 1 289 ? -16.31395 -28.15317 -11.02221 1.000 43.39766  ? 289 HIS A CB  1 
ATOM   1976 C  CG  . HIS A 1 289 ? -16.78494 -28.73956 -9.72939  1.000 50.52207  ? 289 HIS A CG  1 
ATOM   1977 N  ND1 . HIS A 1 289 ? -18.08882 -29.13726 -9.52551  1.000 48.49520  ? 289 HIS A ND1 1 
ATOM   1978 C  CD2 . HIS A 1 289 ? -16.12469 -29.01049 -8.57900  1.000 45.22246  ? 289 HIS A CD2 1 
ATOM   1979 C  CE1 . HIS A 1 289 ? -18.21429 -29.61686 -8.30135  1.000 43.33224  ? 289 HIS A CE1 1 
ATOM   1980 N  NE2 . HIS A 1 289 ? -17.03724 -29.55130 -7.70612  1.000 51.35493  ? 289 HIS A NE2 1 
ATOM   1981 N  N   . VAL A 1 290 ? -17.81948 -28.73116 -14.18382 1.000 42.90837  ? 290 VAL A N   1 
ATOM   1982 C  CA  . VAL A 1 290 ? -19.05320 -28.96376 -14.92279 1.000 47.14524  ? 290 VAL A CA  1 
ATOM   1983 C  C   . VAL A 1 290 ? -19.36996 -30.44626 -14.80874 1.000 52.47659  ? 290 VAL A C   1 
ATOM   1984 O  O   . VAL A 1 290 ? -18.54144 -31.29726 -15.15504 1.000 54.50182  ? 290 VAL A O   1 
ATOM   1985 C  CB  . VAL A 1 290 ? -18.91709 -28.50852 -16.37903 1.000 48.71932  ? 290 VAL A CB  1 
ATOM   1986 C  CG1 . VAL A 1 290 ? -20.23614 -28.68354 -17.10946 1.000 40.59573  ? 290 VAL A CG1 1 
ATOM   1987 C  CG2 . VAL A 1 290 ? -18.46953 -27.05565 -16.44093 1.000 41.16813  ? 290 VAL A CG2 1 
ATOM   1988 N  N   . GLN A 1 291 ? -20.56673 -30.76111 -14.30683 1.000 57.74313  ? 291 GLN A N   1 
ATOM   1989 C  CA  . GLN A 1 291 ? -20.80901 -32.07999 -13.72604 1.000 52.42569  ? 291 GLN A CA  1 
ATOM   1990 C  C   . GLN A 1 291 ? -20.57986 -33.20188 -14.73395 1.000 60.17328  ? 291 GLN A C   1 
ATOM   1991 O  O   . GLN A 1 291 ? -19.90721 -34.19307 -14.42704 1.000 59.01157  ? 291 GLN A O   1 
ATOM   1992 C  CB  . GLN A 1 291 ? -22.22029 -32.14491 -13.14484 1.000 48.49193  ? 291 GLN A CB  1 
ATOM   1993 C  CG  . GLN A 1 291 ? -22.33039 -31.52124 -11.75878 1.000 52.90560  ? 291 GLN A CG  1 
ATOM   1994 C  CD  . GLN A 1 291 ? -21.23437 -31.98812 -10.81107 1.000 58.04194  ? 291 GLN A CD  1 
ATOM   1995 O  OE1 . GLN A 1 291 ? -20.53889 -31.17562 -10.20024 1.000 53.96575  ? 291 GLN A OE1 1 
ATOM   1996 N  NE2 . GLN A 1 291 ? -21.08291 -33.30188 -10.67849 1.000 51.33530  ? 291 GLN A NE2 1 
ATOM   1997 N  N   . SER A 1 292 ? -21.12336 -33.07079 -15.94400 1.000 48.24137  ? 292 SER A N   1 
ATOM   1998 C  CA  . SER A 1 292 ? -20.91786 -34.13312 -16.92070 1.000 61.84069  ? 292 SER A CA  1 
ATOM   1999 C  C   . SER A 1 292 ? -19.55674 -34.06247 -17.59693 1.000 58.93418  ? 292 SER A C   1 
ATOM   2000 O  O   . SER A 1 292 ? -19.18016 -35.01898 -18.28010 1.000 59.46395  ? 292 SER A O   1 
ATOM   2001 C  CB  . SER A 1 292 ? -22.01300 -34.11989 -17.98816 1.000 69.06371  ? 292 SER A CB  1 
ATOM   2002 O  OG  . SER A 1 292 ? -21.83723 -33.03181 -18.87886 1.000 55.31446  ? 292 SER A OG  1 
ATOM   2003 N  N   . HIS A 1 293 ? -18.81346 -32.96558 -17.43511 1.000 53.60291  ? 293 HIS A N   1 
ATOM   2004 C  CA  . HIS A 1 293 ? -17.43743 -32.94581 -17.92118 1.000 50.43283  ? 293 HIS A CA  1 
ATOM   2005 C  C   . HIS A 1 293 ? -16.55485 -33.85027 -17.06912 1.000 56.49189  ? 293 HIS A C   1 
ATOM   2006 O  O   . HIS A 1 293 ? -15.78696 -34.66318 -17.59724 1.000 57.02969  ? 293 HIS A O   1 
ATOM   2007 C  CB  . HIS A 1 293 ? -16.89185 -31.51581 -17.94232 1.000 44.41265  ? 293 HIS A CB  1 
ATOM   2008 C  CG  . HIS A 1 293 ? -17.59234 -30.61037 -18.90864 1.000 54.54924  ? 293 HIS A CG  1 
ATOM   2009 N  ND1 . HIS A 1 293 ? -17.04016 -29.42713 -19.34993 1.000 53.09980  ? 293 HIS A ND1 1 
ATOM   2010 C  CD2 . HIS A 1 293 ? -18.80300 -30.70600 -19.50871 1.000 60.81241  ? 293 HIS A CD2 1 
ATOM   2011 C  CE1 . HIS A 1 293 ? -17.87518 -28.83762 -20.18687 1.000 56.01169  ? 293 HIS A CE1 1 
ATOM   2012 N  NE2 . HIS A 1 293 ? -18.95327 -29.59237 -20.29977 1.000 52.63121  ? 293 HIS A NE2 1 
ATOM   2013 N  N   . SER A 1 294 ? -16.65587 -33.72701 -15.74274 1.000 48.20434  ? 294 SER A N   1 
ATOM   2014 C  CA  . SER A 1 294 ? -15.96587 -34.66449 -14.86385 1.000 53.36928  ? 294 SER A CA  1 
ATOM   2015 C  C   . SER A 1 294 ? -16.53466 -36.07065 -14.99726 1.000 58.96493  ? 294 SER A C   1 
ATOM   2016 O  O   . SER A 1 294 ? -15.79649 -37.05278 -14.85727 1.000 63.99572  ? 294 SER A O   1 
ATOM   2017 C  CB  . SER A 1 294 ? -16.05039 -34.18947 -13.41383 1.000 42.66945  ? 294 SER A CB  1 
ATOM   2018 O  OG  . SER A 1 294 ? -17.39549 -33.96897 -13.02890 1.000 57.70906  ? 294 SER A OG  1 
ATOM   2019 N  N   . ASP A 1 295 ? -17.83849 -36.18784 -15.26247 1.000 50.57564  ? 295 ASP A N   1 
ATOM   2020 C  CA  . ASP A 1 295 ? -18.41525 -37.49489 -15.55253 1.000 50.59076  ? 295 ASP A CA  1 
ATOM   2021 C  C   . ASP A 1 295 ? -17.91087 -38.04095 -16.88193 1.000 57.99184  ? 295 ASP A C   1 
ATOM   2022 O  O   . ASP A 1 295 ? -17.74049 -39.25645 -17.02570 1.000 59.34177  ? 295 ASP A O   1 
ATOM   2023 C  CB  . ASP A 1 295 ? -19.94186 -37.40886 -15.55852 1.000 47.63174  ? 295 ASP A CB  1 
ATOM   2024 C  CG  . ASP A 1 295 ? -20.52493 -37.25218 -14.16710 1.000 57.18912  ? 295 ASP A CG  1 
ATOM   2025 O  OD1 . ASP A 1 295 ? -19.79511 -37.48888 -13.18234 1.000 58.88168  ? 295 ASP A OD1 1 
ATOM   2026 O  OD2 . ASP A 1 295 ? -21.71577 -36.89247 -14.05800 1.000 56.54651  ? 295 ASP A OD2 1 
ATOM   2027 N  N   . MET A 1 296 ? -17.66529 -37.16173 -17.85897 1.000 57.55453  ? 296 MET A N   1 
ATOM   2028 C  CA  . MET A 1 296 ? -17.13343 -37.60241 -19.14450 1.000 52.71349  ? 296 MET A CA  1 
ATOM   2029 C  C   . MET A 1 296 ? -15.72787 -38.16764 -19.00453 1.000 65.50491  ? 296 MET A C   1 
ATOM   2030 O  O   . MET A 1 296 ? -15.30661 -38.99191 -19.82362 1.000 74.37141  ? 296 MET A O   1 
ATOM   2031 C  CB  . MET A 1 296 ? -17.12749 -36.44260 -20.14250 1.000 68.72306  ? 296 MET A CB  1 
ATOM   2032 C  CG  . MET A 1 296 ? -17.94598 -36.68137 -21.39971 1.000 77.71299  ? 296 MET A CG  1 
ATOM   2033 S  SD  . MET A 1 296 ? -19.72223 -36.71847 -21.09090 1.000 108.59469 ? 296 MET A SD  1 
ATOM   2034 C  CE  . MET A 1 296 ? -20.16872 -35.02617 -21.47645 1.000 64.20779  ? 296 MET A CE  1 
ATOM   2035 N  N   . GLY A 1 297 ? -14.98677 -37.73362 -17.98918 1.000 57.36186  ? 297 GLY A N   1 
ATOM   2036 C  CA  . GLY A 1 297 ? -13.63529 -38.21400 -17.79189 1.000 60.31483  ? 297 GLY A CA  1 
ATOM   2037 C  C   . GLY A 1 297 ? -12.59782 -37.11239 -17.80556 1.000 58.23977  ? 297 GLY A C   1 
ATOM   2038 O  O   . GLY A 1 297 ? -11.40105 -37.37885 -17.95347 1.000 54.67546  ? 297 GLY A O   1 
ATOM   2039 N  N   . LEU A 1 298 ? -13.04453 -35.86483 -17.65854 1.000 52.35778  ? 298 LEU A N   1 
ATOM   2040 C  CA  . LEU A 1 298 ? -12.13651 -34.72417 -17.55738 1.000 53.34675  ? 298 LEU A CA  1 
ATOM   2041 C  C   . LEU A 1 298 ? -11.59231 -34.61825 -16.13164 1.000 48.46269  ? 298 LEU A C   1 
ATOM   2042 O  O   . LEU A 1 298 ? -11.80116 -33.63999 -15.41615 1.000 50.35349  ? 298 LEU A O   1 
ATOM   2043 C  CB  . LEU A 1 298 ? -12.84324 -33.44565 -17.98538 1.000 50.92969  ? 298 LEU A CB  1 
ATOM   2044 C  CG  . LEU A 1 298 ? -12.96298 -33.28021 -19.49923 1.000 60.74045  ? 298 LEU A CG  1 
ATOM   2045 C  CD1 . LEU A 1 298 ? -13.75246 -32.03195 -19.85429 1.000 53.50186  ? 298 LEU A CD1 1 
ATOM   2046 C  CD2 . LEU A 1 298 ? -11.57870 -33.23718 -20.11720 1.000 53.87131  ? 298 LEU A CD2 1 
ATOM   2047 N  N   . VAL A 1 299 ? -10.88379 -35.67097 -15.72697 1.000 51.56145  ? 299 VAL A N   1 
ATOM   2048 C  CA  . VAL A 1 299 ? -10.34974 -35.80704 -14.37860 1.000 45.18573  ? 299 VAL A CA  1 
ATOM   2049 C  C   . VAL A 1 299 ? -8.89090  -36.23030 -14.46740 1.000 51.57764  ? 299 VAL A C   1 
ATOM   2050 O  O   . VAL A 1 299 ? -8.51149  -37.01152 -15.34614 1.000 58.85904  ? 299 VAL A O   1 
ATOM   2051 C  CB  . VAL A 1 299 ? -11.14998 -36.83063 -13.54360 1.000 49.96089  ? 299 VAL A CB  1 
ATOM   2052 C  CG1 . VAL A 1 299 ? -10.74110 -36.75808 -12.08363 1.000 50.21400  ? 299 VAL A CG1 1 
ATOM   2053 C  CG2 . VAL A 1 299 ? -12.64521 -36.59902 -13.69048 1.000 52.93544  ? 299 VAL A CG2 1 
ATOM   2054 N  N   . GLY A 1 300 ? -8.07413  -35.70849 -13.55045 1.000 40.27191  ? 300 GLY A N   1 
ATOM   2055 C  CA  . GLY A 1 300 ? -6.70391  -36.14949 -13.41482 1.000 42.08622  ? 300 GLY A CA  1 
ATOM   2056 C  C   . GLY A 1 300 ? -6.34269  -36.28507 -11.94892 1.000 43.07936  ? 300 GLY A C   1 
ATOM   2057 O  O   . GLY A 1 300 ? -7.12829  -35.94269 -11.06266 1.000 45.93715  ? 300 GLY A O   1 
ATOM   2058 N  N   . LEU A 1 301 ? -5.13595  -36.78912 -11.70598 1.000 50.62941  ? 301 LEU A N   1 
ATOM   2059 C  CA  . LEU A 1 301 ? -4.64718  -37.02771 -10.35452 1.000 45.67425  ? 301 LEU A CA  1 
ATOM   2060 C  C   . LEU A 1 301 ? -3.37490  -36.23070 -10.11276 1.000 43.72061  ? 301 LEU A C   1 
ATOM   2061 O  O   . LEU A 1 301 ? -2.42517  -36.31265 -10.89827 1.000 43.21695  ? 301 LEU A O   1 
ATOM   2062 C  CB  . LEU A 1 301 ? -4.38603  -38.51659 -10.11350 1.000 42.68542  ? 301 LEU A CB  1 
ATOM   2063 C  CG  . LEU A 1 301 ? -5.62523  -39.41033 -10.05967 1.000 46.73945  ? 301 LEU A CG  1 
ATOM   2064 C  CD1 . LEU A 1 301 ? -5.23707  -40.84038 -9.72981  1.000 39.87313  ? 301 LEU A CD1 1 
ATOM   2065 C  CD2 . LEU A 1 301 ? -6.62581  -38.87700 -9.04909  1.000 44.95371  ? 301 LEU A CD2 1 
ATOM   2066 N  N   . PHE A 1 302 ? -3.36677  -35.45759 -9.03004  1.000 45.31123  ? 302 PHE A N   1 
ATOM   2067 C  CA  . PHE A 1 302 ? -2.16860  -34.77889 -8.54040  1.000 43.18317  ? 302 PHE A CA  1 
ATOM   2068 C  C   . PHE A 1 302 ? -1.63430  -35.64275 -7.40336  1.000 45.97495  ? 302 PHE A C   1 
ATOM   2069 O  O   . PHE A 1 302 ? -2.03075  -35.49918 -6.24648  1.000 49.75311  ? 302 PHE A O   1 
ATOM   2070 C  CB  . PHE A 1 302 ? -2.49050  -33.35814 -8.09141  1.000 42.96777  ? 302 PHE A CB  1 
ATOM   2071 C  CG  . PHE A 1 302 ? -1.32054  -32.62025 -7.50775  1.000 45.68791  ? 302 PHE A CG  1 
ATOM   2072 C  CD1 . PHE A 1 302 ? -0.04854  -32.78420 -8.02690  1.000 39.05435  ? 302 PHE A CD1 1 
ATOM   2073 C  CD2 . PHE A 1 302 ? -1.49716  -31.75266 -6.44224  1.000 43.31142  ? 302 PHE A CD2 1 
ATOM   2074 C  CE1 . PHE A 1 302 ? 1.02631   -32.09862 -7.49451  1.000 41.10399  ? 302 PHE A CE1 1 
ATOM   2075 C  CE2 . PHE A 1 302 ? -0.42805  -31.06286 -5.90654  1.000 43.76409  ? 302 PHE A CE2 1 
ATOM   2076 C  CZ  . PHE A 1 302 ? 0.83638   -31.23709 -6.43224  1.000 42.64573  ? 302 PHE A CZ  1 
ATOM   2077 N  N   . LEU A 1 303 ? -0.73681  -36.56188 -7.74674  1.000 44.67962  ? 303 LEU A N   1 
ATOM   2078 C  CA  . LEU A 1 303 ? -0.26293  -37.57903 -6.81131  1.000 40.18742  ? 303 LEU A CA  1 
ATOM   2079 C  C   . LEU A 1 303 ? 0.84609   -36.98863 -5.95077  1.000 44.06438  ? 303 LEU A C   1 
ATOM   2080 O  O   . LEU A 1 303 ? 1.98991   -36.85638 -6.39126  1.000 51.33305  ? 303 LEU A O   1 
ATOM   2081 C  CB  . LEU A 1 303 ? 0.21703   -38.80924 -7.57050  1.000 40.43377  ? 303 LEU A CB  1 
ATOM   2082 C  CG  . LEU A 1 303 ? -0.86824  -39.54795 -8.35458  1.000 44.38831  ? 303 LEU A CG  1 
ATOM   2083 C  CD1 . LEU A 1 303 ? -0.24505  -40.53665 -9.32201  1.000 45.73663  ? 303 LEU A CD1 1 
ATOM   2084 C  CD2 . LEU A 1 303 ? -1.83321  -40.25161 -7.41211  1.000 46.54325  ? 303 LEU A CD2 1 
ATOM   2085 N  N   . VAL A 1 304 ? 0.51086   -36.63674 -4.71375  1.000 44.07863  ? 304 VAL A N   1 
ATOM   2086 C  CA  . VAL A 1 304 ? 1.46568   -36.07397 -3.76658  1.000 48.09358  ? 304 VAL A CA  1 
ATOM   2087 C  C   . VAL A 1 304 ? 1.93167   -37.19514 -2.84802  1.000 53.15415  ? 304 VAL A C   1 
ATOM   2088 O  O   . VAL A 1 304 ? 1.11704   -37.83363 -2.17046  1.000 51.42962  ? 304 VAL A O   1 
ATOM   2089 C  CB  . VAL A 1 304 ? 0.84775   -34.91649 -2.96800  1.000 47.98400  ? 304 VAL A CB  1 
ATOM   2090 C  CG1 . VAL A 1 304 ? 1.87563   -34.31699 -2.02334  1.000 40.81924  ? 304 VAL A CG1 1 
ATOM   2091 C  CG2 . VAL A 1 304 ? 0.29850   -33.85901 -3.91398  1.000 39.53714  ? 304 VAL A CG2 1 
ATOM   2092 N  N   . LYS A 1 305 ? 3.23860   -37.43473 -2.82320  1.000 46.49196  ? 305 LYS A N   1 
ATOM   2093 C  CA  . LYS A 1 305 ? 3.81580   -38.56654 -2.11521  1.000 46.57197  ? 305 LYS A CA  1 
ATOM   2094 C  C   . LYS A 1 305 ? 4.43252   -38.13266 -0.79132  1.000 52.32212  ? 305 LYS A C   1 
ATOM   2095 O  O   . LYS A 1 305 ? 4.87077   -36.99038 -0.62948  1.000 41.14278  ? 305 LYS A O   1 
ATOM   2096 C  CB  . LYS A 1 305 ? 4.88273   -39.25359 -2.97153  1.000 40.84727  ? 305 LYS A CB  1 
ATOM   2097 C  CG  . LYS A 1 305 ? 4.41511   -39.64457 -4.36326  1.000 48.63701  ? 305 LYS A CG  1 
ATOM   2098 C  CD  . LYS A 1 305 ? 5.58636   -40.04890 -5.24678  1.000 44.22643  ? 305 LYS A CD  1 
ATOM   2099 C  CE  . LYS A 1 305 ? 6.50633   -38.87125 -5.52340  1.000 47.28083  ? 305 LYS A CE  1 
ATOM   2100 N  NZ  . LYS A 1 305 ? 7.05831   -38.91355 -6.90592  1.000 51.44219  ? 305 LYS A NZ  1 
ATOM   2101 N  N   . LYS A 1 306 ? 4.46259   -39.06766 0.15785   1.000 48.96799  ? 306 LYS A N   1 
ATOM   2102 C  CA  . LYS A 1 306 ? 5.19809   -38.88057 1.39414   1.000 53.06841  ? 306 LYS A CA  1 
ATOM   2103 C  C   . LYS A 1 306 ? 6.69465   -38.90011 1.09289   1.000 57.93179  ? 306 LYS A C   1 
ATOM   2104 O  O   . LYS A 1 306 ? 7.11256   -39.30424 0.00530   1.000 52.09328  ? 306 LYS A O   1 
ATOM   2105 C  CB  . LYS A 1 306 ? 4.83198   -39.97435 2.39707   1.000 49.55716  ? 306 LYS A CB  1 
ATOM   2106 C  CG  . LYS A 1 306 ? 3.39041   -39.95669 2.86673   1.000 60.81463  ? 306 LYS A CG  1 
ATOM   2107 C  CD  . LYS A 1 306 ? 3.26611   -40.58022 4.24698   1.000 57.01685  ? 306 LYS A CD  1 
ATOM   2108 C  CE  . LYS A 1 306 ? 2.62223   -41.95712 4.17832   1.000 72.47017  ? 306 LYS A CE  1 
ATOM   2109 N  NZ  . LYS A 1 306 ? 1.80526   -42.24926 5.39022   1.000 81.43902  ? 306 LYS A NZ  1 
ATOM   2110 N  N   . PRO A 1 307 ? 7.53366   -38.46131 2.03707   1.000 65.18176  ? 307 PRO A N   1 
ATOM   2111 C  CA  . PRO A 1 307 ? 8.98787   -38.56182 1.82122   1.000 58.16541  ? 307 PRO A CA  1 
ATOM   2112 C  C   . PRO A 1 307 ? 9.48484   -39.98162 1.59182   1.000 59.75472  ? 307 PRO A C   1 
ATOM   2113 O  O   . PRO A 1 307 ? 10.61362  -40.15215 1.11505   1.000 68.23551  ? 307 PRO A O   1 
ATOM   2114 C  CB  . PRO A 1 307 ? 9.57273   -37.96187 3.10619   1.000 60.73042  ? 307 PRO A CB  1 
ATOM   2115 C  CG  . PRO A 1 307 ? 8.52574   -37.00879 3.56869   1.000 55.74608  ? 307 PRO A CG  1 
ATOM   2116 C  CD  . PRO A 1 307 ? 7.21580   -37.66944 3.23969   1.000 59.19407  ? 307 PRO A CD  1 
ATOM   2117 N  N   . ASP A 1 308 ? 8.69114   -41.00201 1.91108   1.000 59.78091  ? 308 ASP A N   1 
ATOM   2118 C  CA  . ASP A 1 308 ? 9.05179   -42.38060 1.60794   1.000 66.85527  ? 308 ASP A CA  1 
ATOM   2119 C  C   . ASP A 1 308 ? 8.53865   -42.84630 0.24970   1.000 67.37339  ? 308 ASP A C   1 
ATOM   2120 O  O   . ASP A 1 308 ? 8.73612   -44.01352 -0.10335  1.000 68.23385  ? 308 ASP A O   1 
ATOM   2121 C  CB  . ASP A 1 308 ? 8.54906   -43.32018 2.71507   1.000 75.11363  ? 308 ASP A CB  1 
ATOM   2122 C  CG  . ASP A 1 308 ? 7.03663   -43.28544 2.88833   1.000 78.18304  ? 308 ASP A CG  1 
ATOM   2123 O  OD1 . ASP A 1 308 ? 6.32934   -42.72099 2.02827   1.000 76.27092  ? 308 ASP A OD1 1 
ATOM   2124 O  OD2 . ASP A 1 308 ? 6.55061   -43.83595 3.89848   1.000 89.40403  ? 308 ASP A OD2 1 
ATOM   2125 N  N   . GLY A 1 309 ? 7.88099   -41.97134 -0.51056  1.000 59.76870  ? 309 GLY A N   1 
ATOM   2126 C  CA  . GLY A 1 309 ? 7.44155   -42.28857 -1.85261  1.000 58.00965  ? 309 GLY A CA  1 
ATOM   2127 C  C   . GLY A 1 309 ? 6.06759   -42.91227 -1.96518  1.000 55.02366  ? 309 GLY A C   1 
ATOM   2128 O  O   . GLY A 1 309 ? 5.63615   -43.21688 -3.08527  1.000 65.70958  ? 309 GLY A O   1 
ATOM   2129 N  N   . THR A 1 310 ? 5.36578   -43.11018 -0.85561  1.000 59.63117  ? 310 THR A N   1 
ATOM   2130 C  CA  . THR A 1 310 ? 4.05461   -43.74066 -0.86385  1.000 70.31997  ? 310 THR A CA  1 
ATOM   2131 C  C   . THR A 1 310 ? 2.94092   -42.69917 -0.83044  1.000 59.44242  ? 310 THR A C   1 
ATOM   2132 O  O   . THR A 1 310 ? 3.12927   -41.55750 -0.40155  1.000 52.35043  ? 310 THR A O   1 
ATOM   2133 C  CB  . THR A 1 310 ? 3.90453   -44.70209 0.31929   1.000 67.22394  ? 310 THR A CB  1 
ATOM   2134 O  OG1 . THR A 1 310 ? 3.42497   -43.98652 1.46435   1.000 70.17354  ? 310 THR A OG1 1 
ATOM   2135 C  CG2 . THR A 1 310 ? 5.23314   -45.36748 0.64638   1.000 73.81685  ? 310 THR A CG2 1 
ATOM   2136 N  N   . ILE A 1 311 ? 1.76976   -43.11808 -1.29397  1.000 57.08208  ? 311 ILE A N   1 
ATOM   2137 C  CA  . ILE A 1 311 ? 0.57185   -42.28955 -1.33166  1.000 64.71744  ? 311 ILE A CA  1 
ATOM   2138 C  C   . ILE A 1 311 ? -0.47128  -42.93783 -0.42815  1.000 63.37197  ? 311 ILE A C   1 
ATOM   2139 O  O   . ILE A 1 311 ? -0.79606  -44.11409 -0.61182  1.000 66.43338  ? 311 ILE A O   1 
ATOM   2140 C  CB  . ILE A 1 311 ? 0.02795   -42.12660 -2.75991  1.000 56.41563  ? 311 ILE A CB  1 
ATOM   2141 C  CG1 . ILE A 1 311 ? 1.05572   -41.41955 -3.64389  1.000 58.81212  ? 311 ILE A CG1 1 
ATOM   2142 C  CG2 . ILE A 1 311 ? -1.28439  -41.36942 -2.74750  1.000 59.80661  ? 311 ILE A CG2 1 
ATOM   2143 C  CD1 . ILE A 1 311 ? 1.16281   -42.00278 -5.02663  1.000 60.36885  ? 311 ILE A CD1 1 
ATOM   2144 N  N   . PRO A 1 312 ? -1.00643  -42.21695 0.57466   1.000 58.12755  ? 312 PRO A N   1 
ATOM   2145 C  CA  . PRO A 1 312 ? -2.00122  -42.80501 1.48553   1.000 54.21378  ? 312 PRO A CA  1 
ATOM   2146 C  C   . PRO A 1 312 ? -3.12073  -43.55380 0.77963   1.000 70.53186  ? 312 PRO A C   1 
ATOM   2147 O  O   . PRO A 1 312 ? -3.81338  -42.99947 -0.08008  1.000 64.02933  ? 312 PRO A O   1 
ATOM   2148 C  CB  . PRO A 1 312 ? -2.54421  -41.58409 2.23599   1.000 50.05589  ? 312 PRO A CB  1 
ATOM   2149 C  CG  . PRO A 1 312 ? -1.42986  -40.58440 2.20595   1.000 58.52062  ? 312 PRO A CG  1 
ATOM   2150 C  CD  . PRO A 1 312 ? -0.49319  -40.93006 1.07246   1.000 51.43556  ? 312 PRO A CD  1 
ATOM   2151 N  N   . GLY A 1 313 ? -3.29776  -44.82349 1.14392   1.000 77.79433  ? 313 GLY A N   1 
ATOM   2152 C  CA  . GLY A 1 313 ? -4.26577  -45.69535 0.52401   1.000 84.89939  ? 313 GLY A CA  1 
ATOM   2153 C  C   . GLY A 1 313 ? -3.67724  -46.69559 -0.44977  1.000 98.35007  ? 313 GLY A C   1 
ATOM   2154 O  O   . GLY A 1 313 ? -4.35829  -47.66375 -0.80908  1.000 101.26017 ? 313 GLY A O   1 
ATOM   2155 N  N   . TYR A 1 314 ? -2.43560  -46.49062 -0.88093  1.000 98.15326  ? 314 TYR A N   1 
ATOM   2156 C  CA  . TYR A 1 314 ? -1.80801  -47.35995 -1.87047  1.000 90.98450  ? 314 TYR A CA  1 
ATOM   2157 C  C   . TYR A 1 314 ? -0.35104  -47.63918 -1.51335  1.000 89.28324  ? 314 TYR A C   1 
ATOM   2158 O  O   . TYR A 1 314 ? 0.55955   -46.98056 -2.01668  1.000 90.95685  ? 314 TYR A O   1 
ATOM   2159 C  CB  . TYR A 1 314 ? -1.90124  -46.73271 -3.26440  1.000 72.44483  ? 314 TYR A CB  1 
ATOM   2160 C  CG  . TYR A 1 314 ? -3.27149  -46.17871 -3.58588  1.000 90.28288  ? 314 TYR A CG  1 
ATOM   2161 C  CD1 . TYR A 1 314 ? -4.26739  -46.99562 -4.10523  1.000 93.95879  ? 314 TYR A CD1 1 
ATOM   2162 C  CD2 . TYR A 1 314 ? -3.57352  -44.84143 -3.35713  1.000 85.50716  ? 314 TYR A CD2 1 
ATOM   2163 C  CE1 . TYR A 1 314 ? -5.52381  -46.49573 -4.39449  1.000 91.62976  ? 314 TYR A CE1 1 
ATOM   2164 C  CE2 . TYR A 1 314 ? -4.82692  -44.33280 -3.64207  1.000 87.43245  ? 314 TYR A CE2 1 
ATOM   2165 C  CZ  . TYR A 1 314 ? -5.79778  -45.16435 -4.16117  1.000 97.39653  ? 314 TYR A CZ  1 
ATOM   2166 O  OH  . TYR A 1 314 ? -7.04683  -44.66353 -4.44825  1.000 92.39707  ? 314 TYR A OH  1 
HETATM 2167 CU CU  . CU  B 2 .   ? -15.27345 -28.61577 -18.64015 1.000 62.86257  ? 401 CU  A CU  1 
HETATM 2168 CU CU  . CU  C 2 .   ? -16.81841 -29.41674 -5.60218  1.000 56.70554  ? 402 CU  A CU  1 
HETATM 2169 CU CU  . CU  D 2 .   ? -14.16999 -33.29589 -6.92511  1.000 58.88810  ? 403 CU  A CU  1 
HETATM 2170 CU CU  . CU  E 2 .   ? -13.36726 -30.17790 -4.31471  0.343 50.82762  ? 404 CU  A CU  1 
HETATM 2171 O  O   . OH  F 3 .   ? -15.48678 -31.47939 -6.18317  1.000 32.81314  ? 405 OH  A O   1 
HETATM 2172 N  N   . GLY G 4 .   ? -14.21712 -18.76114 -10.97890 1.000 48.82468  ? 406 GLY A N   1 
HETATM 2173 C  CA  . GLY G 4 .   ? -13.54074 -18.01124 -9.93816  1.000 53.89444  ? 406 GLY A CA  1 
HETATM 2174 C  C   . GLY G 4 .   ? -14.04954 -16.59050 -9.81899  1.000 66.82944  ? 406 GLY A C   1 
HETATM 2175 O  O   . GLY G 4 .   ? -14.62155 -16.05010 -10.76455 1.000 71.71352  ? 406 GLY A O   1 
HETATM 2176 O  OXT . GLY G 4 .   ? -13.90528 -15.94701 -8.77899  1.000 81.04949  ? 406 GLY A OXT 1 
HETATM 2177 N  N   . GLY H 4 .   ? 4.53930   -14.48189 -14.82828 1.000 54.21005  ? 407 GLY A N   1 
HETATM 2178 C  CA  . GLY H 4 .   ? 4.11495   -15.41749 -13.80419 1.000 50.76992  ? 407 GLY A CA  1 
HETATM 2179 C  C   . GLY H 4 .   ? 5.26187   -15.96301 -12.97542 1.000 63.61036  ? 407 GLY A C   1 
HETATM 2180 O  O   . GLY H 4 .   ? 6.42787   -15.87332 -13.36171 1.000 61.89661  ? 407 GLY A O   1 
HETATM 2181 O  OXT . GLY H 4 .   ? 5.05504   -16.51099 -11.89249 1.000 64.60250  ? 407 GLY A OXT 1 
HETATM 2182 O  O1  . PG4 I 5 .   ? -8.64628  -39.89867 -14.99018 1.000 72.84321  ? 408 PG4 A O1  1 
HETATM 2183 C  C1  . PG4 I 5 .   ? -7.35088  -40.11760 -14.45438 1.000 64.70599  ? 408 PG4 A C1  1 
HETATM 2184 C  C2  . PG4 I 5 .   ? -7.11905  -41.56787 -14.15863 1.000 73.42411  ? 408 PG4 A C2  1 
HETATM 2185 O  O2  . PG4 I 5 .   ? -5.73126  -41.79431 -13.95995 1.000 83.99430  ? 408 PG4 A O2  1 
HETATM 2186 C  C3  . PG4 I 5 .   ? -5.31940  -43.10230 -14.33285 1.000 92.94064  ? 408 PG4 A C3  1 
HETATM 2187 C  C4  . PG4 I 5 .   ? -5.38136  -43.26656 -15.81718 1.000 95.12079  ? 408 PG4 A C4  1 
HETATM 2188 O  O3  . PG4 I 5 .   ? -4.38727  -42.46813 -16.44714 1.000 97.41729  ? 408 PG4 A O3  1 
HETATM 2189 C  C5  . PG4 I 5 .   ? -3.13346  -43.09187 -16.20760 1.000 89.27322  ? 408 PG4 A C5  1 
HETATM 2190 C  C6  . PG4 I 5 .   ? -2.08113  -42.45251 -17.05290 1.000 84.62705  ? 408 PG4 A C6  1 
HETATM 2191 O  O4  . PG4 I 5 .   ? -2.06525  -41.05000 -16.82551 1.000 86.08858  ? 408 PG4 A O4  1 
HETATM 2192 C  C7  . PG4 I 5 .   ? -0.70655  -40.63694 -16.86707 1.000 75.82317  ? 408 PG4 A C7  1 
HETATM 2193 C  C8  . PG4 I 5 .   ? -0.57171  -39.44814 -17.76896 1.000 66.40784  ? 408 PG4 A C8  1 
HETATM 2194 O  O5  . PG4 I 5 .   ? 0.69285   -38.83760 -17.56946 1.000 70.70158  ? 408 PG4 A O5  1 
HETATM 2195 O  O1  . PG4 J 5 .   ? 12.39900  -24.11122 -20.19251 1.000 64.61759  ? 409 PG4 A O1  1 
HETATM 2196 C  C1  . PG4 J 5 .   ? 12.61732  -22.91218 -20.91888 1.000 77.22944  ? 409 PG4 A C1  1 
HETATM 2197 C  C2  . PG4 J 5 .   ? 12.28580  -23.08073 -22.37141 1.000 76.50585  ? 409 PG4 A C2  1 
HETATM 2198 O  O2  . PG4 J 5 .   ? 12.19685  -21.80479 -22.99144 1.000 67.26907  ? 409 PG4 A O2  1 
HETATM 2199 C  C3  . PG4 J 5 .   ? 13.32650  -21.49968 -23.79541 1.000 57.90395  ? 409 PG4 A C3  1 
HETATM 2200 C  C4  . PG4 J 5 .   ? 13.33157  -20.04624 -24.13610 1.000 63.79144  ? 409 PG4 A C4  1 
HETATM 2201 O  O3  . PG4 J 5 .   ? 14.63910  -19.51705 -23.96667 1.000 77.46978  ? 409 PG4 A O3  1 
HETATM 2202 C  C5  . PG4 J 5 .   ? 15.41356  -19.95181 -25.07593 1.000 75.73902  ? 409 PG4 A C5  1 
HETATM 2203 C  C6  . PG4 J 5 .   ? 16.85050  -19.61278 -24.84812 1.000 82.94664  ? 409 PG4 A C6  1 
HETATM 2204 O  O4  . PG4 J 5 .   ? 17.60125  -19.87636 -26.02576 1.000 84.91751  ? 409 PG4 A O4  1 
HETATM 2205 C  C7  . PG4 J 5 .   ? 18.62535  -18.89395 -26.08488 1.000 74.16996  ? 409 PG4 A C7  1 
HETATM 2206 C  C8  . PG4 J 5 .   ? 19.43233  -19.07713 -27.33368 1.000 73.85885  ? 409 PG4 A C8  1 
HETATM 2207 O  O5  . PG4 J 5 .   ? 20.33160  -17.98952 -27.47775 1.000 80.14705  ? 409 PG4 A O5  1 
HETATM 2208 N  N   . GLY K 4 .   ? 12.68663  -17.04460 -14.75003 1.000 67.48018  ? 410 GLY A N   1 
HETATM 2209 C  CA  . GLY K 4 .   ? 13.37782  -17.85297 -15.73733 1.000 57.96804  ? 410 GLY A CA  1 
HETATM 2210 C  C   . GLY K 4 .   ? 14.87562  -17.91341 -15.51527 1.000 75.03093  ? 410 GLY A C   1 
HETATM 2211 O  O   . GLY K 4 .   ? 15.39615  -18.89549 -14.98606 1.000 81.69104  ? 410 GLY A O   1 
HETATM 2212 O  OXT . GLY K 4 .   ? 15.60583  -16.98154 -15.85347 1.000 74.06401  ? 410 GLY A OXT 1 
HETATM 2213 N  N   . GLY L 4 .   ? -3.69626  -14.26253 -18.81530 1.000 53.43426  ? 411 GLY A N   1 
HETATM 2214 C  CA  . GLY L 4 .   ? -2.36490  -13.87447 -18.38779 1.000 49.94311  ? 411 GLY A CA  1 
HETATM 2215 C  C   . GLY L 4 .   ? -2.18298  -13.89963 -16.88304 1.000 66.63800  ? 411 GLY A C   1 
HETATM 2216 O  O   . GLY L 4 .   ? -1.07250  -14.09473 -16.38625 1.000 54.07575  ? 411 GLY A O   1 
HETATM 2217 O  OXT . GLY L 4 .   ? -3.13903  -13.72529 -16.12395 1.000 65.88092  ? 411 GLY A OXT 1 
HETATM 2218 O  O   . HOH M 6 .   ? 15.22616  -21.53358 1.78557   1.000 80.38481  ? 501 HOH A O   1 
HETATM 2219 O  O   B HOH M 6 .   ? -11.58905 -29.39755 -21.79908 0.393 53.05332  ? 502 HOH A O   1 
HETATM 2220 O  O   . HOH M 6 .   ? 15.75446  -6.55182  -29.57398 1.000 80.46915  ? 503 HOH A O   1 
HETATM 2221 O  O   . HOH M 6 .   ? -11.92893 -41.21662 -15.11593 1.000 80.38422  ? 504 HOH A O   1 
HETATM 2222 O  O   . HOH M 6 .   ? -3.56106  -36.21187 3.48941   1.000 53.81975  ? 505 HOH A O   1 
HETATM 2223 O  O   . HOH M 6 .   ? -2.148    -11.579   -29.513   1.000 50.87567  ? 506 HOH A O   1 
HETATM 2224 O  O   . HOH M 6 .   ? -4.26462  -8.81493  -36.44290 1.000 49.22340  ? 507 HOH A O   1 
HETATM 2225 O  O   . HOH M 6 .   ? -1.497    0.469     -17.263   1.000 56.00669  ? 508 HOH A O   1 
HETATM 2226 O  O   . HOH M 6 .   ? 5.62749   -32.02006 -9.57139  1.000 46.32852  ? 509 HOH A O   1 
HETATM 2227 O  O   . HOH M 6 .   ? 4.04492   -15.02487 -33.77545 1.000 45.49722  ? 510 HOH A O   1 
HETATM 2228 O  O   . HOH M 6 .   ? 16.64339  -35.08127 -29.11759 1.000 52.40787  ? 511 HOH A O   1 
HETATM 2229 O  O   . HOH M 6 .   ? 16.52928  -30.10956 -40.44990 1.000 76.61740  ? 512 HOH A O   1 
HETATM 2230 O  O   . HOH M 6 .   ? 4.31150   -43.58045 -11.08822 1.000 61.89901  ? 513 HOH A O   1 
HETATM 2231 O  O   . HOH M 6 .   ? 11.92699  -24.12397 -45.14968 1.000 57.97335  ? 514 HOH A O   1 
HETATM 2232 O  O   . HOH M 6 .   ? -9.79333  -27.27400 -2.31425  1.000 46.46158  ? 515 HOH A O   1 
HETATM 2233 O  O   . HOH M 6 .   ? 3.56140   -18.03734 -9.81858  1.000 50.28946  ? 516 HOH A O   1 
HETATM 2234 O  O   . HOH M 6 .   ? 3.80353   -7.61109  -23.67946 1.000 49.80500  ? 517 HOH A O   1 
HETATM 2235 O  O   . HOH M 6 .   ? 9.03500   -39.39072 -32.01740 1.000 45.13505  ? 518 HOH A O   1 
HETATM 2236 O  O   . HOH M 6 .   ? 1.89399   -28.47413 -30.05234 1.000 42.98214  ? 519 HOH A O   1 
HETATM 2237 O  O   . HOH M 6 .   ? -4.89827  -15.55460 -22.49769 1.000 46.11212  ? 520 HOH A O   1 
HETATM 2238 O  O   . HOH M 6 .   ? -4.84173  -41.00022 -1.82555  1.000 50.86575  ? 521 HOH A O   1 
HETATM 2239 O  O   . HOH M 6 .   ? -23.69825 -36.61469 -15.84610 1.000 60.65037  ? 522 HOH A O   1 
HETATM 2240 O  O   . HOH M 6 .   ? -8.68970  -37.21015 -19.13695 1.000 57.10849  ? 523 HOH A O   1 
HETATM 2241 O  O   . HOH M 6 .   ? -8.75724  -26.71552 0.09359   1.000 44.03007  ? 524 HOH A O   1 
HETATM 2242 O  O   . HOH M 6 .   ? -3.30440  -26.95494 0.25264   1.000 53.78752  ? 525 HOH A O   1 
HETATM 2243 O  O   . HOH M 6 .   ? -13.37434 -25.88283 -24.59440 1.000 58.35327  ? 526 HOH A O   1 
HETATM 2244 O  O   . HOH M 6 .   ? 10.88968  -7.58915  -14.35805 1.000 51.44628  ? 527 HOH A O   1 
HETATM 2245 O  O   . HOH M 6 .   ? -2.18627  4.02434   -18.78155 1.000 39.65075  ? 528 HOH A O   1 
HETATM 2246 O  O   . HOH M 6 .   ? -10.27579 -27.25143 -30.14102 1.000 60.96944  ? 529 HOH A O   1 
HETATM 2247 O  O   . HOH M 6 .   ? -2.52223  -16.27349 -13.72427 1.000 48.95076  ? 530 HOH A O   1 
HETATM 2248 O  O   . HOH M 6 .   ? 5.93730   -16.54044 -9.27825  1.000 52.63009  ? 531 HOH A O   1 
HETATM 2249 O  O   . HOH M 6 .   ? 2.606     -1.735    -23.247   1.000 56.96446  ? 532 HOH A O   1 
HETATM 2250 O  O   . HOH M 6 .   ? 7.79607   -8.94433  -34.11479 1.000 53.53055  ? 533 HOH A O   1 
HETATM 2251 O  O   . HOH M 6 .   ? 10.43776  -30.78686 -28.79641 1.000 60.70915  ? 534 HOH A O   1 
HETATM 2252 O  O   . HOH M 6 .   ? 2.23638   -45.34433 -3.49594  1.000 63.65822  ? 535 HOH A O   1 
HETATM 2253 O  O   B HOH M 6 .   ? -12.66427 -29.18985 -18.92411 0.518 57.70151  ? 536 HOH A O   1 
HETATM 2254 O  O   . HOH M 6 .   ? -4.01638  -17.21693 -11.53258 1.000 47.28750  ? 537 HOH A O   1 
HETATM 2255 O  O   . HOH M 6 .   ? 16.79490  -13.56176 -19.31274 1.000 51.58833  ? 538 HOH A O   1 
HETATM 2256 O  O   . HOH M 6 .   ? 13.248    -37.059   -36.465   1.000 46.46654  ? 539 HOH A O   1 
HETATM 2257 O  O   . HOH M 6 .   ? 10.55279  -1.47288  -13.59937 1.000 67.51768  ? 540 HOH A O   1 
HETATM 2258 O  O   . HOH M 6 .   ? -11.166   -16.518   -0.567    1.000 49.04102  ? 541 HOH A O   1 
HETATM 2259 O  O   . HOH M 6 .   ? 12.35981  -21.64473 -5.34156  1.000 67.36681  ? 542 HOH A O   1 
HETATM 2260 O  O   . HOH M 6 .   ? -4.12124  -24.09964 -43.57305 1.000 53.33676  ? 543 HOH A O   1 
HETATM 2261 O  O   . HOH M 6 .   ? -0.39512  -23.90309 -1.28303  1.000 40.83740  ? 544 HOH A O   1 
HETATM 2262 O  O   . HOH M 6 .   ? 3.69299   -3.24587  -25.34490 1.000 50.66829  ? 545 HOH A O   1 
HETATM 2263 O  O   . HOH M 6 .   ? -13.49017 -32.78392 -27.32140 1.000 68.82879  ? 546 HOH A O   1 
HETATM 2264 O  O   . HOH M 6 .   ? 15.38401  -4.20814  -19.90319 1.000 68.00323  ? 547 HOH A O   1 
HETATM 2265 O  O   . HOH M 6 .   ? 2.13693   -7.85375  -16.54932 1.000 48.80948  ? 548 HOH A O   1 
HETATM 2266 O  O   . HOH M 6 .   ? -12.04653 -18.72159 -41.79241 1.000 66.65311  ? 549 HOH A O   1 
HETATM 2267 O  O   . HOH M 6 .   ? -21.34412 -28.36350 -21.19812 1.000 66.71715  ? 550 HOH A O   1 
HETATM 2268 O  O   . HOH M 6 .   ? 3.55676   -3.35918  -12.79144 1.000 52.04188  ? 551 HOH A O   1 
HETATM 2269 O  O   . HOH M 6 .   ? -7.04467  -14.92268 -19.79148 1.000 48.56671  ? 552 HOH A O   1 
HETATM 2270 O  O   . HOH M 6 .   ? -6.59672  -13.90230 -41.33946 1.000 56.27162  ? 553 HOH A O   1 
HETATM 2271 O  O   . HOH M 6 .   ? 12.19466  -23.86386 -5.65556  1.000 66.97062  ? 554 HOH A O   1 
HETATM 2272 O  O   . HOH M 6 .   ? -4.22088  -32.19472 -43.10635 1.000 73.04054  ? 555 HOH A O   1 
HETATM 2273 O  O   . HOH M 6 .   ? -16.48663 -40.89778 -21.60365 1.000 73.59139  ? 556 HOH A O   1 
HETATM 2274 O  O   . HOH M 6 .   ? 8.47585   -9.29771  -36.83308 1.000 61.45410  ? 557 HOH A O   1 
HETATM 2275 O  O   . HOH M 6 .   ? 15.83527  -34.18832 -26.64349 1.000 75.49645  ? 558 HOH A O   1 
HETATM 2276 O  O   . HOH M 6 .   ? -9.73212  -21.58851 -28.46149 1.000 49.86486  ? 559 HOH A O   1 
HETATM 2277 O  O   . HOH M 6 .   ? 1.32289   -7.16240  1.24667   1.000 74.12725  ? 560 HOH A O   1 
HETATM 2278 O  O   . HOH M 6 .   ? -9.09637  -35.86656 -21.47138 1.000 54.20404  ? 561 HOH A O   1 
HETATM 2279 O  O   . HOH M 6 .   ? -6.43836  -18.08199 -11.01075 1.000 46.32291  ? 562 HOH A O   1 
HETATM 2280 O  O   . HOH M 6 .   ? 2.76950   -4.85960  -14.86432 1.000 49.12005  ? 563 HOH A O   1 
HETATM 2281 O  O   . HOH M 6 .   ? 10.82384  -11.01834 -37.30975 1.000 58.06084  ? 564 HOH A O   1 
HETATM 2282 O  O   . HOH M 6 .   ? -7.965    -17.657   -33.010   1.000 62.14640  ? 565 HOH A O   1 
HETATM 2283 O  O   . HOH M 6 .   ? -2.03611  1.41786   -19.88672 1.000 48.74489  ? 566 HOH A O   1 
HETATM 2284 O  O   . HOH M 6 .   ? -0.66127  -20.47445 -3.54764  1.000 59.79758  ? 567 HOH A O   1 
HETATM 2285 O  O   . HOH M 6 .   ? 6.94843   -36.13596 -33.14002 1.000 56.72023  ? 568 HOH A O   1 
HETATM 2286 O  O   . HOH M 6 .   ? 15.475    -31.004   -35.507   1.000 47.60654  ? 569 HOH A O   1 
HETATM 2287 O  O   . HOH M 6 .   ? -5.18484  -13.32641 -21.16888 1.000 44.65789  ? 570 HOH A O   1 
HETATM 2288 O  O   . HOH M 6 .   ? 8.57865   -1.80374  -25.84588 1.000 61.41003  ? 571 HOH A O   1 
HETATM 2289 O  O   . HOH M 6 .   ? 11.49410  -14.70473 -41.82648 1.000 58.05689  ? 572 HOH A O   1 
HETATM 2290 O  O   . HOH M 6 .   ? 1.48763   -13.33239 -32.43510 1.000 48.41421  ? 573 HOH A O   1 
HETATM 2291 O  O   . HOH M 6 .   ? -2.83071  -24.75276 -47.13000 1.000 61.07030  ? 574 HOH A O   1 
HETATM 2292 O  O   . HOH M 6 .   ? 10.22015  -6.35960  -10.31719 1.000 63.73791  ? 575 HOH A O   1 
HETATM 2293 O  O   . HOH M 6 .   ? -17.50325 -32.01836 -10.74348 1.000 58.65958  ? 576 HOH A O   1 
HETATM 2294 O  O   . HOH M 6 .   ? 8.78359   -4.09547  -26.22856 1.000 67.30119  ? 577 HOH A O   1 
HETATM 2295 O  O   . HOH M 6 .   ? 18.88641  -9.91139  -11.76485 1.000 67.49650  ? 578 HOH A O   1 
HETATM 2296 O  O   . HOH M 6 .   ? -1.94328  -22.18357 -1.18352  1.000 57.88623  ? 579 HOH A O   1 
HETATM 2297 O  O   . HOH M 6 .   ? 17.16873  -4.75927  -12.64081 1.000 77.02643  ? 580 HOH A O   1 
HETATM 2298 O  O   . HOH M 6 .   ? 17.181    -29.564   -36.309   1.000 68.97074  ? 581 HOH A O   1 
HETATM 2299 O  O   . HOH M 6 .   ? -9.34856  -30.93418 -37.22480 1.000 67.28135  ? 582 HOH A O   1 
HETATM 2300 O  O   . HOH M 6 .   ? 11.05962  -26.88284 -2.22181  1.000 61.92889  ? 583 HOH A O   1 
HETATM 2301 O  O   . HOH M 6 .   ? 12.00027  -3.63250  -20.84848 1.000 44.81192  ? 584 HOH A O   1 
HETATM 2302 O  O   . HOH M 6 .   ? -19.87009 -24.16817 -22.92231 1.000 69.79482  ? 585 HOH A O   1 
HETATM 2303 O  O   . HOH M 6 .   ? 7.67356   -40.84231 4.80713   1.000 70.68151  ? 586 HOH A O   1 
HETATM 2304 O  O   . HOH M 6 .   ? 15.40770  -24.79690 -30.49164 1.000 59.76783  ? 587 HOH A O   1 
HETATM 2305 O  O   . HOH M 6 .   ? 8.51073   -30.79094 -26.89064 1.000 63.45567  ? 588 HOH A O   1 
HETATM 2306 O  O   . HOH M 6 .   ? 5.39850   -28.19898 -19.35197 1.000 48.88030  ? 589 HOH A O   1 
HETATM 2307 O  O   . HOH M 6 .   ? 4.40031   -31.07765 -23.39762 1.000 59.37293  ? 590 HOH A O   1 
HETATM 2308 O  O   . HOH M 6 .   ? 2.49932   -35.49806 -27.38830 1.000 57.64874  ? 591 HOH A O   1 
HETATM 2309 O  O   . HOH M 6 .   ? -7.00020  -12.08134 0.38992   1.000 59.33028  ? 592 HOH A O   1 
HETATM 2310 O  O   . HOH M 6 .   ? 18.72643  -7.04838  -8.24274  1.000 85.04984  ? 593 HOH A O   1 
HETATM 2311 O  O   . HOH M 6 .   ? 13.47998  -16.92795 -42.03281 1.000 61.67071  ? 594 HOH A O   1 
HETATM 2312 O  O   . HOH M 6 .   ? 21.72838  -11.37539 -25.38463 1.000 68.12885  ? 595 HOH A O   1 
HETATM 2313 O  O   . HOH M 6 .   ? 17.19728  -8.33719  -31.65240 1.000 69.64799  ? 596 HOH A O   1 
HETATM 2314 O  O   . HOH M 6 .   ? -13.29171 -26.36103 -31.45333 1.000 69.59284  ? 597 HOH A O   1 
HETATM 2315 O  O   . HOH M 6 .   ? 2.00331   -29.13938 5.80360   1.000 56.95602  ? 598 HOH A O   1 
HETATM 2316 O  O   . HOH M 6 .   ? -10.72482 -25.39758 -31.89824 1.000 53.73242  ? 599 HOH A O   1 
HETATM 2317 O  O   . HOH M 6 .   ? 7.39985   -9.82333  -8.13893  1.000 59.80246  ? 600 HOH A O   1 
HETATM 2318 O  O   . HOH M 6 .   ? 3.73560   -30.54882 -18.51675 1.000 57.28224  ? 601 HOH A O   1 
HETATM 2319 O  O   . HOH M 6 .   ? 17.13862  -15.75539 -4.81569  1.000 71.89887  ? 602 HOH A O   1 
HETATM 2320 O  O   . HOH M 6 .   ? 1.10370   -36.90233 4.96265   1.000 47.17111  ? 603 HOH A O   1 
HETATM 2321 O  O   . HOH M 6 .   ? 1.44758   -7.14252  -14.06716 1.000 44.72555  ? 604 HOH A O   1 
HETATM 2322 O  O   . HOH M 6 .   ? -7.37196  -20.89237 -43.88937 1.000 56.13109  ? 605 HOH A O   1 
HETATM 2323 O  O   . HOH M 6 .   ? -2.54392  -24.96086 -1.50765  1.000 42.13659  ? 606 HOH A O   1 
HETATM 2324 O  O   . HOH M 6 .   ? 4.68283   -28.58682 -22.12786 1.000 51.00774  ? 607 HOH A O   1 
HETATM 2325 O  O   . HOH M 6 .   ? -6.28898  -25.61060 -43.77480 1.000 59.65825  ? 608 HOH A O   1 
HETATM 2326 O  O   . HOH M 6 .   ? 9.97339   3.28130   -14.24298 1.000 63.61327  ? 609 HOH A O   1 
HETATM 2327 O  O   . HOH M 6 .   ? 20.76622  -9.19605  -19.06342 1.000 58.15771  ? 610 HOH A O   1 
HETATM 2328 O  O   . HOH M 6 .   ? 12.28317  -4.06561  -23.85835 1.000 65.88870  ? 611 HOH A O   1 
HETATM 2329 O  O   . HOH M 6 .   ? 17.73536  -16.86476 -7.00621  1.000 69.63958  ? 612 HOH A O   1 
HETATM 2330 O  O   . HOH M 6 .   ? 2.09679   -32.74365 -16.66324 1.000 66.11720  ? 613 HOH A O   1 
HETATM 2331 O  O   . HOH M 6 .   ? 5.89208   -14.35493 -7.73953  1.000 49.48604  ? 614 HOH A O   1 
HETATM 2332 O  O   . HOH M 6 .   ? -3.95695  -10.75959 5.65371   1.000 55.81476  ? 615 HOH A O   1 
HETATM 2333 O  O   . HOH M 6 .   ? 17.82116  -18.18035 -9.48049  1.000 75.64245  ? 616 HOH A O   1 
HETATM 2334 O  O   . HOH M 6 .   ? 6.36219   -37.56207 -31.24098 1.000 53.74418  ? 617 HOH A O   1 
HETATM 2335 O  O   . HOH M 6 .   ? 1.86482   -31.43708 5.51952   1.000 68.55728  ? 618 HOH A O   1 
HETATM 2336 O  O   . HOH M 6 .   ? 7.50362   -31.51785 -24.20037 1.000 69.94079  ? 619 HOH A O   1 
HETATM 2337 O  O   . HOH M 6 .   ? -5.478    -3.226    -0.043    1.000 74.05539  ? 620 HOH A O   1 
HETATM 2338 O  O   . HOH M 6 .   ? 12.29444  -5.08510  -25.95323 1.000 70.73501  ? 621 HOH A O   1 
HETATM 2339 O  O   . HOH M 6 .   ? 7.669     -1.633    -32.765   1.000 68.21907  ? 622 HOH A O   1 
HETATM 2340 O  O   . HOH M 6 .   ? -11.63272 -13.44766 -40.02626 1.000 72.94404  ? 623 HOH A O   1 
HETATM 2341 O  O   . HOH M 6 .   ? -20.02190 -26.25173 -21.32640 1.000 63.72563  ? 624 HOH A O   1 
HETATM 2342 O  O   . HOH M 6 .   ? -17.782   -40.989   -13.959   1.000 80.39898  ? 625 HOH A O   1 
HETATM 2343 O  O   . HOH M 6 .   ? -7.99821  -23.01400 -44.46072 1.000 71.64412  ? 626 HOH A O   1 
HETATM 2344 O  O   . HOH M 6 .   ? 5.95652   -11.83796 -6.73025  1.000 69.71595  ? 627 HOH A O   1 
HETATM 2345 O  O   . HOH M 6 .   ? -14.751   -40.392   -13.882   1.000 67.47360  ? 628 HOH A O   1 
HETATM 2346 O  O   . HOH M 6 .   ? 3.13737   -35.05827 -24.93799 1.000 69.52008  ? 629 HOH A O   1 
HETATM 2347 O  O   . HOH M 6 .   ? -12.08175 -26.72200 -39.06793 1.000 67.92281  ? 630 HOH A O   1 
HETATM 2348 O  O   . HOH M 6 .   ? 14.79195  -4.41419  -13.63982 1.000 70.12843  ? 631 HOH A O   1 
HETATM 2349 O  O   . HOH M 6 .   ? 19.10905  -9.18430  -32.53707 1.000 76.23383  ? 632 HOH A O   1 
HETATM 2350 O  O   . HOH M 6 .   ? 1.41576   -28.64448 -50.62701 1.000 68.82026  ? 633 HOH A O   1 
HETATM 2351 O  O   . HOH M 6 .   ? 8.17309   -31.27199 4.31226   1.000 76.20430  ? 634 HOH A O   1 
HETATM 2352 O  O   . HOH M 6 .   ? -3.23598  -30.57259 -49.23635 1.000 69.18011  ? 635 HOH A O   1 
HETATM 2353 O  O   . HOH M 6 .   ? -14.19784 -26.31835 -38.29919 1.000 79.64711  ? 636 HOH A O   1 
HETATM 2354 O  O   . HOH M 6 .   ? 5.676     -1.852    -37.833   1.000 63.97217  ? 637 HOH A O   1 
HETATM 2355 O  O   . HOH M 6 .   ? 10.97713  4.12307   -16.25932 1.000 72.74583  ? 638 HOH A O   1 
HETATM 2356 O  O   . HOH M 6 .   ? 11.24417  -8.41041  -37.09839 1.000 68.55122  ? 639 HOH A O   1 
HETATM 2357 O  O   . HOH M 6 .   ? 1.55725   -26.68152 7.35471   1.000 66.28922  ? 640 HOH A O   1 
HETATM 2358 O  O   . HOH M 6 .   ? 10.33558  -12.10801 -41.58752 1.000 61.89564  ? 641 HOH A O   1 
HETATM 2359 O  O   . HOH M 6 .   ? 1.41584   -36.90549 -28.87065 1.000 66.23274  ? 642 HOH A O   1 
HETATM 2360 O  O   . HOH M 6 .   ? -4.81952  -20.59240 -45.45622 1.000 73.70394  ? 643 HOH A O   1 
HETATM 2361 O  O   . HOH M 6 .   ? -4.69276  -23.34791 -46.65515 1.000 78.61465  ? 644 HOH A O   1 
HETATM 2362 O  O   . HOH M 6 .   ? 3.34277   -36.52736 4.97046   1.000 64.13401  ? 645 HOH A O   1 
HETATM 2363 O  O   . HOH M 6 .   ? 15.85421  -21.43344 -43.88998 1.000 73.17847  ? 646 HOH A O   1 
HETATM 2364 O  O   . HOH M 6 .   ? 11.10774  -5.10929  -12.98171 1.000 60.96226  ? 647 HOH A O   1 
HETATM 2365 O  O   . HOH M 6 .   ? 4.26168   -28.64905 3.93112   1.000 69.94973  ? 648 HOH A O   1 
HETATM 2366 O  O   . HOH M 6 .   ? -22.12653 -22.12653 -22.12653 0.33  71.50482  ? 649 HOH A O   1 
# 
