data_9NAA
# 
_entry.id   9NAA 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9NAA         pdb_00009naa 10.2210/pdb9naa/pdb 
WWPDB D_1000292869 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-14 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9NAA 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              smarius@uwm.edu 
_pdbx_contact_author.name_first         Marius 
_pdbx_contact_author.name_last          Schmidt 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0962-9468 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Schmidt, M.' 1 0000-0002-0962-9468 
'Prabin, K.'  2 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Struct Dyn.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2329-7778 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            12 
_citation.language                  ? 
_citation.page_first                034701 
_citation.page_last                 034701 
_citation.title                     
'Structures of myxobacterial phytochrome revealed by cryo-EM using the Spotiton technique and with x-ray crystallography.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1063/4.0000301 
_citation.pdbx_database_id_PubMed   40322674 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Karki, P.'       1  0009-0001-6011-7548 
primary 'Menendez, D.'    2  0009-0006-9680-029X 
primary 'Budell, W.'      3  ?                   
primary 'Dangi, S.'       4  ?                   
primary 'Hernandez, C.'   5  0000-0003-4183-9008 
primary 'Mendez, J.'      6  0000-0002-3317-5654 
primary 'Muniyappan, S.'  7  0000-0001-9428-3846 
primary 'Basu, S.'        8  0000-0001-6484-8236 
primary 'Schwander, P.'   9  0000-0003-2350-8838 
primary 'Malla, T.N.'     10 0000-0002-1387-0801 
primary 'Stojkovic, E.A.' 11 0000-0002-4971-5213 
primary 'Schmidt, M.'     12 0000-0002-0962-9468 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'histidine kinase' 32473.533 2   2.7.13.3 ? ? ? 
2 non-polymer syn 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
584.662   2   ?        ? ? ? 
3 water       nat water 18.015    384 ?        ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;DLSQCDREPIHLLGGIQSHGVLLAFRGPDRLLEVVSANAQALLGRPPETLLGQPVGRVLPAEVLAQWEPLVARGSVRVVL
PAGAYRALLHESDGLTVLELEPAELQPDMEETALEVVRRLVSPLAGVKGTQALLQTAADTVRALTGFDRVMVYRFDADWH
GEVLAESKRGGMDGFLGMHFPATDIPVQARALYTRNPLRLIADARARPVPLLPPVVPALGRPLDLSNSALRSVSPVHLEY
LRNMGVGASFSLSLLKEGVLWGLIACHHLEPLHISHERRRACEVLTQLLALQLSAEER
;
_entity_poly.pdbx_seq_one_letter_code_can   
;DLSQCDREPIHLLGGIQSHGVLLAFRGPDRLLEVVSANAQALLGRPPETLLGQPVGRVLPAEVLAQWEPLVARGSVRVVL
PAGAYRALLHESDGLTVLELEPAELQPDMEETALEVVRRLVSPLAGVKGTQALLQTAADTVRALTGFDRVMVYRFDADWH
GEVLAESKRGGMDGFLGMHFPATDIPVQARALYTRNPLRLIADARARPVPLLPPVVPALGRPLDLSNSALRSVSPVHLEY
LRNMGVGASFSLSLLKEGVLWGLIACHHLEPLHISHERRRACEVLTQLLALQLSAEER
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
EL5 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   LEU n 
1 3   SER n 
1 4   GLN n 
1 5   CYS n 
1 6   ASP n 
1 7   ARG n 
1 8   GLU n 
1 9   PRO n 
1 10  ILE n 
1 11  HIS n 
1 12  LEU n 
1 13  LEU n 
1 14  GLY n 
1 15  GLY n 
1 16  ILE n 
1 17  GLN n 
1 18  SER n 
1 19  HIS n 
1 20  GLY n 
1 21  VAL n 
1 22  LEU n 
1 23  LEU n 
1 24  ALA n 
1 25  PHE n 
1 26  ARG n 
1 27  GLY n 
1 28  PRO n 
1 29  ASP n 
1 30  ARG n 
1 31  LEU n 
1 32  LEU n 
1 33  GLU n 
1 34  VAL n 
1 35  VAL n 
1 36  SER n 
1 37  ALA n 
1 38  ASN n 
1 39  ALA n 
1 40  GLN n 
1 41  ALA n 
1 42  LEU n 
1 43  LEU n 
1 44  GLY n 
1 45  ARG n 
1 46  PRO n 
1 47  PRO n 
1 48  GLU n 
1 49  THR n 
1 50  LEU n 
1 51  LEU n 
1 52  GLY n 
1 53  GLN n 
1 54  PRO n 
1 55  VAL n 
1 56  GLY n 
1 57  ARG n 
1 58  VAL n 
1 59  LEU n 
1 60  PRO n 
1 61  ALA n 
1 62  GLU n 
1 63  VAL n 
1 64  LEU n 
1 65  ALA n 
1 66  GLN n 
1 67  TRP n 
1 68  GLU n 
1 69  PRO n 
1 70  LEU n 
1 71  VAL n 
1 72  ALA n 
1 73  ARG n 
1 74  GLY n 
1 75  SER n 
1 76  VAL n 
1 77  ARG n 
1 78  VAL n 
1 79  VAL n 
1 80  LEU n 
1 81  PRO n 
1 82  ALA n 
1 83  GLY n 
1 84  ALA n 
1 85  TYR n 
1 86  ARG n 
1 87  ALA n 
1 88  LEU n 
1 89  LEU n 
1 90  HIS n 
1 91  GLU n 
1 92  SER n 
1 93  ASP n 
1 94  GLY n 
1 95  LEU n 
1 96  THR n 
1 97  VAL n 
1 98  LEU n 
1 99  GLU n 
1 100 LEU n 
1 101 GLU n 
1 102 PRO n 
1 103 ALA n 
1 104 GLU n 
1 105 LEU n 
1 106 GLN n 
1 107 PRO n 
1 108 ASP n 
1 109 MET n 
1 110 GLU n 
1 111 GLU n 
1 112 THR n 
1 113 ALA n 
1 114 LEU n 
1 115 GLU n 
1 116 VAL n 
1 117 VAL n 
1 118 ARG n 
1 119 ARG n 
1 120 LEU n 
1 121 VAL n 
1 122 SER n 
1 123 PRO n 
1 124 LEU n 
1 125 ALA n 
1 126 GLY n 
1 127 VAL n 
1 128 LYS n 
1 129 GLY n 
1 130 THR n 
1 131 GLN n 
1 132 ALA n 
1 133 LEU n 
1 134 LEU n 
1 135 GLN n 
1 136 THR n 
1 137 ALA n 
1 138 ALA n 
1 139 ASP n 
1 140 THR n 
1 141 VAL n 
1 142 ARG n 
1 143 ALA n 
1 144 LEU n 
1 145 THR n 
1 146 GLY n 
1 147 PHE n 
1 148 ASP n 
1 149 ARG n 
1 150 VAL n 
1 151 MET n 
1 152 VAL n 
1 153 TYR n 
1 154 ARG n 
1 155 PHE n 
1 156 ASP n 
1 157 ALA n 
1 158 ASP n 
1 159 TRP n 
1 160 HIS n 
1 161 GLY n 
1 162 GLU n 
1 163 VAL n 
1 164 LEU n 
1 165 ALA n 
1 166 GLU n 
1 167 SER n 
1 168 LYS n 
1 169 ARG n 
1 170 GLY n 
1 171 GLY n 
1 172 MET n 
1 173 ASP n 
1 174 GLY n 
1 175 PHE n 
1 176 LEU n 
1 177 GLY n 
1 178 MET n 
1 179 HIS n 
1 180 PHE n 
1 181 PRO n 
1 182 ALA n 
1 183 THR n 
1 184 ASP n 
1 185 ILE n 
1 186 PRO n 
1 187 VAL n 
1 188 GLN n 
1 189 ALA n 
1 190 ARG n 
1 191 ALA n 
1 192 LEU n 
1 193 TYR n 
1 194 THR n 
1 195 ARG n 
1 196 ASN n 
1 197 PRO n 
1 198 LEU n 
1 199 ARG n 
1 200 LEU n 
1 201 ILE n 
1 202 ALA n 
1 203 ASP n 
1 204 ALA n 
1 205 ARG n 
1 206 ALA n 
1 207 ARG n 
1 208 PRO n 
1 209 VAL n 
1 210 PRO n 
1 211 LEU n 
1 212 LEU n 
1 213 PRO n 
1 214 PRO n 
1 215 VAL n 
1 216 VAL n 
1 217 PRO n 
1 218 ALA n 
1 219 LEU n 
1 220 GLY n 
1 221 ARG n 
1 222 PRO n 
1 223 LEU n 
1 224 ASP n 
1 225 LEU n 
1 226 SER n 
1 227 ASN n 
1 228 SER n 
1 229 ALA n 
1 230 LEU n 
1 231 ARG n 
1 232 SER n 
1 233 VAL n 
1 234 SER n 
1 235 PRO n 
1 236 VAL n 
1 237 HIS n 
1 238 LEU n 
1 239 GLU n 
1 240 TYR n 
1 241 LEU n 
1 242 ARG n 
1 243 ASN n 
1 244 MET n 
1 245 GLY n 
1 246 VAL n 
1 247 GLY n 
1 248 ALA n 
1 249 SER n 
1 250 PHE n 
1 251 SER n 
1 252 LEU n 
1 253 SER n 
1 254 LEU n 
1 255 LEU n 
1 256 LYS n 
1 257 GLU n 
1 258 GLY n 
1 259 VAL n 
1 260 LEU n 
1 261 TRP n 
1 262 GLY n 
1 263 LEU n 
1 264 ILE n 
1 265 ALA n 
1 266 CYS n 
1 267 HIS n 
1 268 HIS n 
1 269 LEU n 
1 270 GLU n 
1 271 PRO n 
1 272 LEU n 
1 273 HIS n 
1 274 ILE n 
1 275 SER n 
1 276 HIS n 
1 277 GLU n 
1 278 ARG n 
1 279 ARG n 
1 280 ARG n 
1 281 ALA n 
1 282 CYS n 
1 283 GLU n 
1 284 VAL n 
1 285 LEU n 
1 286 THR n 
1 287 GLN n 
1 288 LEU n 
1 289 LEU n 
1 290 ALA n 
1 291 LEU n 
1 292 GLN n 
1 293 LEU n 
1 294 SER n 
1 295 ALA n 
1 296 GLU n 
1 297 GLU n 
1 298 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   298 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 STIAU_8420 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Stigmatella aurantiaca' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     41 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                                     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                                     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                     'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ?                                     'C3 H7 N O2 S'   121.158 
EL5 non-polymer         . 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
'biliverdin, bound form at Pfr state' 'C33 H36 N4 O6'  584.662 
GLN 'L-peptide linking' y GLUTAMINE ?                                     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                     'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ?                                     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ?                                     'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                                     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                                     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                                     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                                     'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ?                                     'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                                     'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ?                                     'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                     'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                                     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                                     'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   9   9   ASP ASP A . n 
A 1 2   LEU 2   10  10  LEU LEU A . n 
A 1 3   SER 3   11  11  SER SER A . n 
A 1 4   GLN 4   12  12  GLN GLN A . n 
A 1 5   CYS 5   13  13  CYS CYS A . n 
A 1 6   ASP 6   14  14  ASP ASP A . n 
A 1 7   ARG 7   15  15  ARG ARG A . n 
A 1 8   GLU 8   16  16  GLU GLU A . n 
A 1 9   PRO 9   17  17  PRO PRO A . n 
A 1 10  ILE 10  18  18  ILE ILE A . n 
A 1 11  HIS 11  19  19  HIS HIS A . n 
A 1 12  LEU 12  20  20  LEU LEU A . n 
A 1 13  LEU 13  21  21  LEU LEU A . n 
A 1 14  GLY 14  22  22  GLY GLY A . n 
A 1 15  GLY 15  23  23  GLY GLY A . n 
A 1 16  ILE 16  24  24  ILE ILE A . n 
A 1 17  GLN 17  25  25  GLN GLN A . n 
A 1 18  SER 18  26  26  SER SER A . n 
A 1 19  HIS 19  27  27  HIS HIS A . n 
A 1 20  GLY 20  28  28  GLY GLY A . n 
A 1 21  VAL 21  29  29  VAL VAL A . n 
A 1 22  LEU 22  30  30  LEU LEU A . n 
A 1 23  LEU 23  31  31  LEU LEU A . n 
A 1 24  ALA 24  32  32  ALA ALA A . n 
A 1 25  PHE 25  33  33  PHE PHE A . n 
A 1 26  ARG 26  34  34  ARG ARG A . n 
A 1 27  GLY 27  35  35  GLY GLY A . n 
A 1 28  PRO 28  36  36  PRO PRO A . n 
A 1 29  ASP 29  37  37  ASP ASP A . n 
A 1 30  ARG 30  38  38  ARG ARG A . n 
A 1 31  LEU 31  39  39  LEU LEU A . n 
A 1 32  LEU 32  40  40  LEU LEU A . n 
A 1 33  GLU 33  41  41  GLU GLU A . n 
A 1 34  VAL 34  42  42  VAL VAL A . n 
A 1 35  VAL 35  43  43  VAL VAL A . n 
A 1 36  SER 36  44  44  SER SER A . n 
A 1 37  ALA 37  45  45  ALA ALA A . n 
A 1 38  ASN 38  46  46  ASN ASN A . n 
A 1 39  ALA 39  47  47  ALA ALA A . n 
A 1 40  GLN 40  48  48  GLN GLN A . n 
A 1 41  ALA 41  49  49  ALA ALA A . n 
A 1 42  LEU 42  50  50  LEU LEU A . n 
A 1 43  LEU 43  51  51  LEU LEU A . n 
A 1 44  GLY 44  52  52  GLY GLY A . n 
A 1 45  ARG 45  53  53  ARG ARG A . n 
A 1 46  PRO 46  54  54  PRO PRO A . n 
A 1 47  PRO 47  55  55  PRO PRO A . n 
A 1 48  GLU 48  56  56  GLU GLU A . n 
A 1 49  THR 49  57  57  THR THR A . n 
A 1 50  LEU 50  58  58  LEU LEU A . n 
A 1 51  LEU 51  59  59  LEU LEU A . n 
A 1 52  GLY 52  60  60  GLY GLY A . n 
A 1 53  GLN 53  61  61  GLN GLN A . n 
A 1 54  PRO 54  62  62  PRO PRO A . n 
A 1 55  VAL 55  63  63  VAL VAL A . n 
A 1 56  GLY 56  64  64  GLY GLY A . n 
A 1 57  ARG 57  65  65  ARG ARG A . n 
A 1 58  VAL 58  66  66  VAL VAL A . n 
A 1 59  LEU 59  67  67  LEU LEU A . n 
A 1 60  PRO 60  68  68  PRO PRO A . n 
A 1 61  ALA 61  69  69  ALA ALA A . n 
A 1 62  GLU 62  70  70  GLU GLU A . n 
A 1 63  VAL 63  71  71  VAL VAL A . n 
A 1 64  LEU 64  72  72  LEU LEU A . n 
A 1 65  ALA 65  73  73  ALA ALA A . n 
A 1 66  GLN 66  74  74  GLN GLN A . n 
A 1 67  TRP 67  75  75  TRP TRP A . n 
A 1 68  GLU 68  76  76  GLU GLU A . n 
A 1 69  PRO 69  77  77  PRO PRO A . n 
A 1 70  LEU 70  78  78  LEU LEU A . n 
A 1 71  VAL 71  79  79  VAL VAL A . n 
A 1 72  ALA 72  80  80  ALA ALA A . n 
A 1 73  ARG 73  81  81  ARG ARG A . n 
A 1 74  GLY 74  82  82  GLY GLY A . n 
A 1 75  SER 75  83  83  SER SER A . n 
A 1 76  VAL 76  84  84  VAL VAL A . n 
A 1 77  ARG 77  85  85  ARG ARG A . n 
A 1 78  VAL 78  86  86  VAL VAL A . n 
A 1 79  VAL 79  87  87  VAL VAL A . n 
A 1 80  LEU 80  88  88  LEU LEU A . n 
A 1 81  PRO 81  89  89  PRO PRO A . n 
A 1 82  ALA 82  90  90  ALA ALA A . n 
A 1 83  GLY 83  91  91  GLY GLY A . n 
A 1 84  ALA 84  92  92  ALA ALA A . n 
A 1 85  TYR 85  93  93  TYR TYR A . n 
A 1 86  ARG 86  94  94  ARG ARG A . n 
A 1 87  ALA 87  95  95  ALA ALA A . n 
A 1 88  LEU 88  96  96  LEU LEU A . n 
A 1 89  LEU 89  97  97  LEU LEU A . n 
A 1 90  HIS 90  98  98  HIS HIS A . n 
A 1 91  GLU 91  99  99  GLU GLU A . n 
A 1 92  SER 92  100 100 SER SER A . n 
A 1 93  ASP 93  101 101 ASP ASP A . n 
A 1 94  GLY 94  102 102 GLY GLY A . n 
A 1 95  LEU 95  103 103 LEU LEU A . n 
A 1 96  THR 96  104 104 THR THR A . n 
A 1 97  VAL 97  105 105 VAL VAL A . n 
A 1 98  LEU 98  106 106 LEU LEU A . n 
A 1 99  GLU 99  107 107 GLU GLU A . n 
A 1 100 LEU 100 108 108 LEU LEU A . n 
A 1 101 GLU 101 109 109 GLU GLU A . n 
A 1 102 PRO 102 110 110 PRO PRO A . n 
A 1 103 ALA 103 111 111 ALA ALA A . n 
A 1 104 GLU 104 112 112 GLU GLU A . n 
A 1 105 LEU 105 113 113 LEU LEU A . n 
A 1 106 GLN 106 114 114 GLN GLN A . n 
A 1 107 PRO 107 115 115 PRO PRO A . n 
A 1 108 ASP 108 116 116 ASP ASP A . n 
A 1 109 MET 109 117 ?   ?   ?   A . n 
A 1 110 GLU 110 118 ?   ?   ?   A . n 
A 1 111 GLU 111 119 ?   ?   ?   A . n 
A 1 112 THR 112 120 ?   ?   ?   A . n 
A 1 113 ALA 113 121 ?   ?   ?   A . n 
A 1 114 LEU 114 122 ?   ?   ?   A . n 
A 1 115 GLU 115 123 ?   ?   ?   A . n 
A 1 116 VAL 116 124 ?   ?   ?   A . n 
A 1 117 VAL 117 125 ?   ?   ?   A . n 
A 1 118 ARG 118 126 ?   ?   ?   A . n 
A 1 119 ARG 119 127 ?   ?   ?   A . n 
A 1 120 LEU 120 128 ?   ?   ?   A . n 
A 1 121 VAL 121 129 ?   ?   ?   A . n 
A 1 122 SER 122 130 ?   ?   ?   A . n 
A 1 123 PRO 123 131 ?   ?   ?   A . n 
A 1 124 LEU 124 132 ?   ?   ?   A . n 
A 1 125 ALA 125 133 ?   ?   ?   A . n 
A 1 126 GLY 126 134 ?   ?   ?   A . n 
A 1 127 VAL 127 135 ?   ?   ?   A . n 
A 1 128 LYS 128 136 ?   ?   ?   A . n 
A 1 129 GLY 129 137 137 GLY GLY A . n 
A 1 130 THR 130 138 138 THR THR A . n 
A 1 131 GLN 131 139 139 GLN GLN A . n 
A 1 132 ALA 132 140 140 ALA ALA A . n 
A 1 133 LEU 133 141 141 LEU LEU A . n 
A 1 134 LEU 134 142 142 LEU LEU A . n 
A 1 135 GLN 135 143 143 GLN GLN A . n 
A 1 136 THR 136 144 144 THR THR A . n 
A 1 137 ALA 137 145 145 ALA ALA A . n 
A 1 138 ALA 138 146 146 ALA ALA A . n 
A 1 139 ASP 139 147 147 ASP ASP A . n 
A 1 140 THR 140 148 148 THR THR A . n 
A 1 141 VAL 141 149 149 VAL VAL A . n 
A 1 142 ARG 142 150 150 ARG ARG A . n 
A 1 143 ALA 143 151 151 ALA ALA A . n 
A 1 144 LEU 144 152 152 LEU LEU A . n 
A 1 145 THR 145 153 153 THR THR A . n 
A 1 146 GLY 146 154 154 GLY GLY A . n 
A 1 147 PHE 147 155 155 PHE PHE A . n 
A 1 148 ASP 148 156 156 ASP ASP A . n 
A 1 149 ARG 149 157 157 ARG ARG A . n 
A 1 150 VAL 150 158 158 VAL VAL A . n 
A 1 151 MET 151 159 159 MET MET A . n 
A 1 152 VAL 152 160 160 VAL VAL A . n 
A 1 153 TYR 153 161 161 TYR TYR A . n 
A 1 154 ARG 154 162 162 ARG ARG A . n 
A 1 155 PHE 155 163 163 PHE PHE A . n 
A 1 156 ASP 156 164 164 ASP ASP A . n 
A 1 157 ALA 157 165 165 ALA ALA A . n 
A 1 158 ASP 158 166 166 ASP ASP A . n 
A 1 159 TRP 159 167 167 TRP TRP A . n 
A 1 160 HIS 160 168 168 HIS HIS A . n 
A 1 161 GLY 161 169 169 GLY GLY A . n 
A 1 162 GLU 162 170 170 GLU GLU A . n 
A 1 163 VAL 163 171 171 VAL VAL A . n 
A 1 164 LEU 164 172 172 LEU LEU A . n 
A 1 165 ALA 165 173 173 ALA ALA A . n 
A 1 166 GLU 166 174 174 GLU GLU A . n 
A 1 167 SER 167 175 175 SER SER A . n 
A 1 168 LYS 168 176 176 LYS LYS A . n 
A 1 169 ARG 169 177 177 ARG ARG A . n 
A 1 170 GLY 170 178 178 GLY GLY A . n 
A 1 171 GLY 171 179 179 GLY GLY A . n 
A 1 172 MET 172 180 180 MET MET A . n 
A 1 173 ASP 173 181 181 ASP ASP A . n 
A 1 174 GLY 174 182 182 GLY GLY A . n 
A 1 175 PHE 175 183 183 PHE PHE A . n 
A 1 176 LEU 176 184 184 LEU LEU A . n 
A 1 177 GLY 177 185 185 GLY GLY A . n 
A 1 178 MET 178 186 186 MET MET A . n 
A 1 179 HIS 179 187 187 HIS HIS A . n 
A 1 180 PHE 180 188 188 PHE PHE A . n 
A 1 181 PRO 181 189 189 PRO PRO A . n 
A 1 182 ALA 182 190 190 ALA ALA A . n 
A 1 183 THR 183 191 191 THR THR A . n 
A 1 184 ASP 184 192 192 ASP ASP A . n 
A 1 185 ILE 185 193 193 ILE ILE A . n 
A 1 186 PRO 186 194 194 PRO PRO A . n 
A 1 187 VAL 187 195 195 VAL VAL A . n 
A 1 188 GLN 188 196 196 GLN GLN A . n 
A 1 189 ALA 189 197 197 ALA ALA A . n 
A 1 190 ARG 190 198 198 ARG ARG A . n 
A 1 191 ALA 191 199 199 ALA ALA A . n 
A 1 192 LEU 192 200 200 LEU LEU A . n 
A 1 193 TYR 193 201 201 TYR TYR A . n 
A 1 194 THR 194 202 202 THR THR A . n 
A 1 195 ARG 195 203 203 ARG ARG A . n 
A 1 196 ASN 196 204 204 ASN ASN A . n 
A 1 197 PRO 197 205 205 PRO PRO A . n 
A 1 198 LEU 198 206 206 LEU LEU A . n 
A 1 199 ARG 199 207 207 ARG ARG A . n 
A 1 200 LEU 200 208 208 LEU LEU A . n 
A 1 201 ILE 201 209 209 ILE ILE A . n 
A 1 202 ALA 202 210 210 ALA ALA A . n 
A 1 203 ASP 203 211 211 ASP ASP A . n 
A 1 204 ALA 204 212 212 ALA ALA A . n 
A 1 205 ARG 205 213 213 ARG ARG A . n 
A 1 206 ALA 206 214 214 ALA ALA A . n 
A 1 207 ARG 207 215 215 ARG ARG A . n 
A 1 208 PRO 208 216 216 PRO PRO A . n 
A 1 209 VAL 209 217 217 VAL VAL A . n 
A 1 210 PRO 210 218 218 PRO PRO A . n 
A 1 211 LEU 211 219 219 LEU LEU A . n 
A 1 212 LEU 212 220 220 LEU LEU A . n 
A 1 213 PRO 213 221 221 PRO PRO A . n 
A 1 214 PRO 214 222 222 PRO PRO A . n 
A 1 215 VAL 215 223 223 VAL VAL A . n 
A 1 216 VAL 216 224 224 VAL VAL A . n 
A 1 217 PRO 217 225 225 PRO PRO A . n 
A 1 218 ALA 218 226 226 ALA ALA A . n 
A 1 219 LEU 219 227 227 LEU LEU A . n 
A 1 220 GLY 220 228 228 GLY GLY A . n 
A 1 221 ARG 221 229 229 ARG ARG A . n 
A 1 222 PRO 222 230 230 PRO PRO A . n 
A 1 223 LEU 223 231 231 LEU LEU A . n 
A 1 224 ASP 224 232 232 ASP ASP A . n 
A 1 225 LEU 225 233 233 LEU LEU A . n 
A 1 226 SER 226 234 234 SER SER A . n 
A 1 227 ASN 227 235 235 ASN ASN A . n 
A 1 228 SER 228 236 236 SER SER A . n 
A 1 229 ALA 229 237 237 ALA ALA A . n 
A 1 230 LEU 230 238 238 LEU LEU A . n 
A 1 231 ARG 231 239 239 ARG ARG A . n 
A 1 232 SER 232 240 240 SER SER A . n 
A 1 233 VAL 233 241 241 VAL VAL A . n 
A 1 234 SER 234 242 242 SER SER A . n 
A 1 235 PRO 235 243 243 PRO PRO A . n 
A 1 236 VAL 236 244 244 VAL VAL A . n 
A 1 237 HIS 237 245 245 HIS HIS A . n 
A 1 238 LEU 238 246 246 LEU LEU A . n 
A 1 239 GLU 239 247 247 GLU GLU A . n 
A 1 240 TYR 240 248 248 TYR TYR A . n 
A 1 241 LEU 241 249 249 LEU LEU A . n 
A 1 242 ARG 242 250 250 ARG ARG A . n 
A 1 243 ASN 243 251 251 ASN ASN A . n 
A 1 244 MET 244 252 252 MET MET A . n 
A 1 245 GLY 245 253 253 GLY GLY A . n 
A 1 246 VAL 246 254 254 VAL VAL A . n 
A 1 247 GLY 247 255 255 GLY GLY A . n 
A 1 248 ALA 248 256 256 ALA ALA A . n 
A 1 249 SER 249 257 257 SER SER A . n 
A 1 250 PHE 250 258 258 PHE PHE A . n 
A 1 251 SER 251 259 259 SER SER A . n 
A 1 252 LEU 252 260 260 LEU LEU A . n 
A 1 253 SER 253 261 261 SER SER A . n 
A 1 254 LEU 254 262 262 LEU LEU A . n 
A 1 255 LEU 255 263 263 LEU LEU A . n 
A 1 256 LYS 256 264 264 LYS LYS A . n 
A 1 257 GLU 257 265 265 GLU GLU A . n 
A 1 258 GLY 258 266 266 GLY GLY A . n 
A 1 259 VAL 259 267 267 VAL VAL A . n 
A 1 260 LEU 260 268 268 LEU LEU A . n 
A 1 261 TRP 261 269 269 TRP TRP A . n 
A 1 262 GLY 262 270 270 GLY GLY A . n 
A 1 263 LEU 263 271 271 LEU LEU A . n 
A 1 264 ILE 264 272 272 ILE ILE A . n 
A 1 265 ALA 265 273 273 ALA ALA A . n 
A 1 266 CYS 266 274 274 CYS CYS A . n 
A 1 267 HIS 267 275 275 HIS HIS A . n 
A 1 268 HIS 268 276 276 HIS HIS A . n 
A 1 269 LEU 269 277 277 LEU LEU A . n 
A 1 270 GLU 270 278 278 GLU GLU A . n 
A 1 271 PRO 271 279 279 PRO PRO A . n 
A 1 272 LEU 272 280 280 LEU LEU A . n 
A 1 273 HIS 273 281 281 HIS HIS A . n 
A 1 274 ILE 274 282 282 ILE ILE A . n 
A 1 275 SER 275 283 283 SER SER A . n 
A 1 276 HIS 276 284 284 HIS HIS A . n 
A 1 277 GLU 277 285 285 GLU GLU A . n 
A 1 278 ARG 278 286 286 ARG ARG A . n 
A 1 279 ARG 279 287 287 ARG ARG A . n 
A 1 280 ARG 280 288 288 ARG ARG A . n 
A 1 281 ALA 281 289 289 ALA ALA A . n 
A 1 282 CYS 282 290 290 CYS CYS A . n 
A 1 283 GLU 283 291 291 GLU GLU A . n 
A 1 284 VAL 284 292 292 VAL VAL A . n 
A 1 285 LEU 285 293 293 LEU LEU A . n 
A 1 286 THR 286 294 294 THR THR A . n 
A 1 287 GLN 287 295 295 GLN GLN A . n 
A 1 288 LEU 288 296 296 LEU LEU A . n 
A 1 289 LEU 289 297 297 LEU LEU A . n 
A 1 290 ALA 290 298 298 ALA ALA A . n 
A 1 291 LEU 291 299 299 LEU LEU A . n 
A 1 292 GLN 292 300 300 GLN GLN A . n 
A 1 293 LEU 293 301 301 LEU LEU A . n 
A 1 294 SER 294 302 302 SER SER A . n 
A 1 295 ALA 295 303 303 ALA ALA A . n 
A 1 296 GLU 296 304 304 GLU GLU A . n 
A 1 297 GLU 297 305 305 GLU GLU A . n 
A 1 298 ARG 298 306 306 ARG ARG A . n 
B 1 1   ASP 1   9   9   ASP ASP B . n 
B 1 2   LEU 2   10  10  LEU LEU B . n 
B 1 3   SER 3   11  11  SER SER B . n 
B 1 4   GLN 4   12  12  GLN GLN B . n 
B 1 5   CYS 5   13  13  CYS CYS B . n 
B 1 6   ASP 6   14  14  ASP ASP B . n 
B 1 7   ARG 7   15  15  ARG ARG B . n 
B 1 8   GLU 8   16  16  GLU GLU B . n 
B 1 9   PRO 9   17  17  PRO PRO B . n 
B 1 10  ILE 10  18  18  ILE ILE B . n 
B 1 11  HIS 11  19  19  HIS HIS B . n 
B 1 12  LEU 12  20  20  LEU LEU B . n 
B 1 13  LEU 13  21  21  LEU LEU B . n 
B 1 14  GLY 14  22  22  GLY GLY B . n 
B 1 15  GLY 15  23  23  GLY GLY B . n 
B 1 16  ILE 16  24  24  ILE ILE B . n 
B 1 17  GLN 17  25  25  GLN GLN B . n 
B 1 18  SER 18  26  26  SER SER B . n 
B 1 19  HIS 19  27  27  HIS HIS B . n 
B 1 20  GLY 20  28  28  GLY GLY B . n 
B 1 21  VAL 21  29  29  VAL VAL B . n 
B 1 22  LEU 22  30  30  LEU LEU B . n 
B 1 23  LEU 23  31  31  LEU LEU B . n 
B 1 24  ALA 24  32  32  ALA ALA B . n 
B 1 25  PHE 25  33  33  PHE PHE B . n 
B 1 26  ARG 26  34  34  ARG ARG B . n 
B 1 27  GLY 27  35  35  GLY GLY B . n 
B 1 28  PRO 28  36  36  PRO PRO B . n 
B 1 29  ASP 29  37  37  ASP ASP B . n 
B 1 30  ARG 30  38  38  ARG ARG B . n 
B 1 31  LEU 31  39  39  LEU LEU B . n 
B 1 32  LEU 32  40  40  LEU LEU B . n 
B 1 33  GLU 33  41  41  GLU GLU B . n 
B 1 34  VAL 34  42  42  VAL VAL B . n 
B 1 35  VAL 35  43  43  VAL VAL B . n 
B 1 36  SER 36  44  44  SER SER B . n 
B 1 37  ALA 37  45  45  ALA ALA B . n 
B 1 38  ASN 38  46  46  ASN ASN B . n 
B 1 39  ALA 39  47  47  ALA ALA B . n 
B 1 40  GLN 40  48  48  GLN GLN B . n 
B 1 41  ALA 41  49  49  ALA ALA B . n 
B 1 42  LEU 42  50  50  LEU LEU B . n 
B 1 43  LEU 43  51  51  LEU LEU B . n 
B 1 44  GLY 44  52  52  GLY GLY B . n 
B 1 45  ARG 45  53  53  ARG ARG B . n 
B 1 46  PRO 46  54  54  PRO PRO B . n 
B 1 47  PRO 47  55  55  PRO PRO B . n 
B 1 48  GLU 48  56  56  GLU GLU B . n 
B 1 49  THR 49  57  57  THR THR B . n 
B 1 50  LEU 50  58  58  LEU LEU B . n 
B 1 51  LEU 51  59  59  LEU LEU B . n 
B 1 52  GLY 52  60  60  GLY GLY B . n 
B 1 53  GLN 53  61  61  GLN GLN B . n 
B 1 54  PRO 54  62  62  PRO PRO B . n 
B 1 55  VAL 55  63  63  VAL VAL B . n 
B 1 56  GLY 56  64  64  GLY GLY B . n 
B 1 57  ARG 57  65  65  ARG ARG B . n 
B 1 58  VAL 58  66  66  VAL VAL B . n 
B 1 59  LEU 59  67  67  LEU LEU B . n 
B 1 60  PRO 60  68  68  PRO PRO B . n 
B 1 61  ALA 61  69  69  ALA ALA B . n 
B 1 62  GLU 62  70  70  GLU GLU B . n 
B 1 63  VAL 63  71  71  VAL VAL B . n 
B 1 64  LEU 64  72  72  LEU LEU B . n 
B 1 65  ALA 65  73  73  ALA ALA B . n 
B 1 66  GLN 66  74  74  GLN GLN B . n 
B 1 67  TRP 67  75  75  TRP TRP B . n 
B 1 68  GLU 68  76  76  GLU GLU B . n 
B 1 69  PRO 69  77  77  PRO PRO B . n 
B 1 70  LEU 70  78  78  LEU LEU B . n 
B 1 71  VAL 71  79  79  VAL VAL B . n 
B 1 72  ALA 72  80  80  ALA ALA B . n 
B 1 73  ARG 73  81  81  ARG ARG B . n 
B 1 74  GLY 74  82  82  GLY GLY B . n 
B 1 75  SER 75  83  83  SER SER B . n 
B 1 76  VAL 76  84  84  VAL VAL B . n 
B 1 77  ARG 77  85  85  ARG ARG B . n 
B 1 78  VAL 78  86  86  VAL VAL B . n 
B 1 79  VAL 79  87  87  VAL VAL B . n 
B 1 80  LEU 80  88  88  LEU LEU B . n 
B 1 81  PRO 81  89  89  PRO PRO B . n 
B 1 82  ALA 82  90  90  ALA ALA B . n 
B 1 83  GLY 83  91  91  GLY GLY B . n 
B 1 84  ALA 84  92  92  ALA ALA B . n 
B 1 85  TYR 85  93  93  TYR TYR B . n 
B 1 86  ARG 86  94  94  ARG ARG B . n 
B 1 87  ALA 87  95  95  ALA ALA B . n 
B 1 88  LEU 88  96  96  LEU LEU B . n 
B 1 89  LEU 89  97  97  LEU LEU B . n 
B 1 90  HIS 90  98  98  HIS HIS B . n 
B 1 91  GLU 91  99  99  GLU GLU B . n 
B 1 92  SER 92  100 100 SER SER B . n 
B 1 93  ASP 93  101 101 ASP ASP B . n 
B 1 94  GLY 94  102 102 GLY GLY B . n 
B 1 95  LEU 95  103 103 LEU LEU B . n 
B 1 96  THR 96  104 104 THR THR B . n 
B 1 97  VAL 97  105 105 VAL VAL B . n 
B 1 98  LEU 98  106 106 LEU LEU B . n 
B 1 99  GLU 99  107 107 GLU GLU B . n 
B 1 100 LEU 100 108 108 LEU LEU B . n 
B 1 101 GLU 101 109 109 GLU GLU B . n 
B 1 102 PRO 102 110 110 PRO PRO B . n 
B 1 103 ALA 103 111 111 ALA ALA B . n 
B 1 104 GLU 104 112 112 GLU GLU B . n 
B 1 105 LEU 105 113 113 LEU LEU B . n 
B 1 106 GLN 106 114 114 GLN GLN B . n 
B 1 107 PRO 107 115 115 PRO PRO B . n 
B 1 108 ASP 108 116 ?   ?   ?   B . n 
B 1 109 MET 109 117 ?   ?   ?   B . n 
B 1 110 GLU 110 118 ?   ?   ?   B . n 
B 1 111 GLU 111 119 ?   ?   ?   B . n 
B 1 112 THR 112 120 ?   ?   ?   B . n 
B 1 113 ALA 113 121 ?   ?   ?   B . n 
B 1 114 LEU 114 122 ?   ?   ?   B . n 
B 1 115 GLU 115 123 ?   ?   ?   B . n 
B 1 116 VAL 116 124 ?   ?   ?   B . n 
B 1 117 VAL 117 125 ?   ?   ?   B . n 
B 1 118 ARG 118 126 ?   ?   ?   B . n 
B 1 119 ARG 119 127 ?   ?   ?   B . n 
B 1 120 LEU 120 128 ?   ?   ?   B . n 
B 1 121 VAL 121 129 ?   ?   ?   B . n 
B 1 122 SER 122 130 ?   ?   ?   B . n 
B 1 123 PRO 123 131 ?   ?   ?   B . n 
B 1 124 LEU 124 132 ?   ?   ?   B . n 
B 1 125 ALA 125 133 ?   ?   ?   B . n 
B 1 126 GLY 126 134 ?   ?   ?   B . n 
B 1 127 VAL 127 135 ?   ?   ?   B . n 
B 1 128 LYS 128 136 ?   ?   ?   B . n 
B 1 129 GLY 129 137 137 GLY GLY B . n 
B 1 130 THR 130 138 138 THR THR B . n 
B 1 131 GLN 131 139 139 GLN GLN B . n 
B 1 132 ALA 132 140 140 ALA ALA B . n 
B 1 133 LEU 133 141 141 LEU LEU B . n 
B 1 134 LEU 134 142 142 LEU LEU B . n 
B 1 135 GLN 135 143 143 GLN GLN B . n 
B 1 136 THR 136 144 144 THR THR B . n 
B 1 137 ALA 137 145 145 ALA ALA B . n 
B 1 138 ALA 138 146 146 ALA ALA B . n 
B 1 139 ASP 139 147 147 ASP ASP B . n 
B 1 140 THR 140 148 148 THR THR B . n 
B 1 141 VAL 141 149 149 VAL VAL B . n 
B 1 142 ARG 142 150 150 ARG ARG B . n 
B 1 143 ALA 143 151 151 ALA ALA B . n 
B 1 144 LEU 144 152 152 LEU LEU B . n 
B 1 145 THR 145 153 153 THR THR B . n 
B 1 146 GLY 146 154 154 GLY GLY B . n 
B 1 147 PHE 147 155 155 PHE PHE B . n 
B 1 148 ASP 148 156 156 ASP ASP B . n 
B 1 149 ARG 149 157 157 ARG ARG B . n 
B 1 150 VAL 150 158 158 VAL VAL B . n 
B 1 151 MET 151 159 159 MET MET B . n 
B 1 152 VAL 152 160 160 VAL VAL B . n 
B 1 153 TYR 153 161 161 TYR TYR B . n 
B 1 154 ARG 154 162 162 ARG ARG B . n 
B 1 155 PHE 155 163 163 PHE PHE B . n 
B 1 156 ASP 156 164 164 ASP ASP B . n 
B 1 157 ALA 157 165 165 ALA ALA B . n 
B 1 158 ASP 158 166 166 ASP ASP B . n 
B 1 159 TRP 159 167 167 TRP TRP B . n 
B 1 160 HIS 160 168 168 HIS HIS B . n 
B 1 161 GLY 161 169 169 GLY GLY B . n 
B 1 162 GLU 162 170 170 GLU GLU B . n 
B 1 163 VAL 163 171 171 VAL VAL B . n 
B 1 164 LEU 164 172 172 LEU LEU B . n 
B 1 165 ALA 165 173 173 ALA ALA B . n 
B 1 166 GLU 166 174 174 GLU GLU B . n 
B 1 167 SER 167 175 175 SER SER B . n 
B 1 168 LYS 168 176 176 LYS LYS B . n 
B 1 169 ARG 169 177 177 ARG ARG B . n 
B 1 170 GLY 170 178 178 GLY GLY B . n 
B 1 171 GLY 171 179 179 GLY GLY B . n 
B 1 172 MET 172 180 180 MET MET B . n 
B 1 173 ASP 173 181 181 ASP ASP B . n 
B 1 174 GLY 174 182 182 GLY GLY B . n 
B 1 175 PHE 175 183 183 PHE PHE B . n 
B 1 176 LEU 176 184 184 LEU LEU B . n 
B 1 177 GLY 177 185 185 GLY GLY B . n 
B 1 178 MET 178 186 186 MET MET B . n 
B 1 179 HIS 179 187 187 HIS HIS B . n 
B 1 180 PHE 180 188 188 PHE PHE B . n 
B 1 181 PRO 181 189 189 PRO PRO B . n 
B 1 182 ALA 182 190 190 ALA ALA B . n 
B 1 183 THR 183 191 191 THR THR B . n 
B 1 184 ASP 184 192 192 ASP ASP B . n 
B 1 185 ILE 185 193 193 ILE ILE B . n 
B 1 186 PRO 186 194 194 PRO PRO B . n 
B 1 187 VAL 187 195 195 VAL VAL B . n 
B 1 188 GLN 188 196 196 GLN GLN B . n 
B 1 189 ALA 189 197 197 ALA ALA B . n 
B 1 190 ARG 190 198 198 ARG ARG B . n 
B 1 191 ALA 191 199 199 ALA ALA B . n 
B 1 192 LEU 192 200 200 LEU LEU B . n 
B 1 193 TYR 193 201 201 TYR TYR B . n 
B 1 194 THR 194 202 202 THR THR B . n 
B 1 195 ARG 195 203 203 ARG ARG B . n 
B 1 196 ASN 196 204 204 ASN ASN B . n 
B 1 197 PRO 197 205 205 PRO PRO B . n 
B 1 198 LEU 198 206 206 LEU LEU B . n 
B 1 199 ARG 199 207 207 ARG ARG B . n 
B 1 200 LEU 200 208 208 LEU LEU B . n 
B 1 201 ILE 201 209 209 ILE ILE B . n 
B 1 202 ALA 202 210 210 ALA ALA B . n 
B 1 203 ASP 203 211 211 ASP ASP B . n 
B 1 204 ALA 204 212 212 ALA ALA B . n 
B 1 205 ARG 205 213 213 ARG ARG B . n 
B 1 206 ALA 206 214 214 ALA ALA B . n 
B 1 207 ARG 207 215 215 ARG ARG B . n 
B 1 208 PRO 208 216 216 PRO PRO B . n 
B 1 209 VAL 209 217 217 VAL VAL B . n 
B 1 210 PRO 210 218 218 PRO PRO B . n 
B 1 211 LEU 211 219 219 LEU LEU B . n 
B 1 212 LEU 212 220 220 LEU LEU B . n 
B 1 213 PRO 213 221 221 PRO PRO B . n 
B 1 214 PRO 214 222 222 PRO PRO B . n 
B 1 215 VAL 215 223 223 VAL VAL B . n 
B 1 216 VAL 216 224 224 VAL VAL B . n 
B 1 217 PRO 217 225 225 PRO PRO B . n 
B 1 218 ALA 218 226 226 ALA ALA B . n 
B 1 219 LEU 219 227 227 LEU LEU B . n 
B 1 220 GLY 220 228 228 GLY GLY B . n 
B 1 221 ARG 221 229 229 ARG ARG B . n 
B 1 222 PRO 222 230 230 PRO PRO B . n 
B 1 223 LEU 223 231 231 LEU LEU B . n 
B 1 224 ASP 224 232 232 ASP ASP B . n 
B 1 225 LEU 225 233 233 LEU LEU B . n 
B 1 226 SER 226 234 234 SER SER B . n 
B 1 227 ASN 227 235 235 ASN ASN B . n 
B 1 228 SER 228 236 236 SER SER B . n 
B 1 229 ALA 229 237 237 ALA ALA B . n 
B 1 230 LEU 230 238 238 LEU LEU B . n 
B 1 231 ARG 231 239 239 ARG ARG B . n 
B 1 232 SER 232 240 240 SER SER B . n 
B 1 233 VAL 233 241 241 VAL VAL B . n 
B 1 234 SER 234 242 242 SER SER B . n 
B 1 235 PRO 235 243 243 PRO PRO B . n 
B 1 236 VAL 236 244 244 VAL VAL B . n 
B 1 237 HIS 237 245 245 HIS HIS B . n 
B 1 238 LEU 238 246 246 LEU LEU B . n 
B 1 239 GLU 239 247 247 GLU GLU B . n 
B 1 240 TYR 240 248 248 TYR TYR B . n 
B 1 241 LEU 241 249 249 LEU LEU B . n 
B 1 242 ARG 242 250 250 ARG ARG B . n 
B 1 243 ASN 243 251 251 ASN ASN B . n 
B 1 244 MET 244 252 252 MET MET B . n 
B 1 245 GLY 245 253 253 GLY GLY B . n 
B 1 246 VAL 246 254 254 VAL VAL B . n 
B 1 247 GLY 247 255 255 GLY GLY B . n 
B 1 248 ALA 248 256 256 ALA ALA B . n 
B 1 249 SER 249 257 257 SER SER B . n 
B 1 250 PHE 250 258 258 PHE PHE B . n 
B 1 251 SER 251 259 259 SER SER B . n 
B 1 252 LEU 252 260 260 LEU LEU B . n 
B 1 253 SER 253 261 261 SER SER B . n 
B 1 254 LEU 254 262 262 LEU LEU B . n 
B 1 255 LEU 255 263 263 LEU LEU B . n 
B 1 256 LYS 256 264 264 LYS LYS B . n 
B 1 257 GLU 257 265 265 GLU GLU B . n 
B 1 258 GLY 258 266 266 GLY GLY B . n 
B 1 259 VAL 259 267 267 VAL VAL B . n 
B 1 260 LEU 260 268 268 LEU LEU B . n 
B 1 261 TRP 261 269 269 TRP TRP B . n 
B 1 262 GLY 262 270 270 GLY GLY B . n 
B 1 263 LEU 263 271 271 LEU LEU B . n 
B 1 264 ILE 264 272 272 ILE ILE B . n 
B 1 265 ALA 265 273 273 ALA ALA B . n 
B 1 266 CYS 266 274 274 CYS CYS B . n 
B 1 267 HIS 267 275 275 HIS HIS B . n 
B 1 268 HIS 268 276 276 HIS HIS B . n 
B 1 269 LEU 269 277 277 LEU LEU B . n 
B 1 270 GLU 270 278 278 GLU GLU B . n 
B 1 271 PRO 271 279 279 PRO PRO B . n 
B 1 272 LEU 272 280 280 LEU LEU B . n 
B 1 273 HIS 273 281 281 HIS HIS B . n 
B 1 274 ILE 274 282 282 ILE ILE B . n 
B 1 275 SER 275 283 283 SER SER B . n 
B 1 276 HIS 276 284 284 HIS HIS B . n 
B 1 277 GLU 277 285 285 GLU GLU B . n 
B 1 278 ARG 278 286 286 ARG ARG B . n 
B 1 279 ARG 279 287 287 ARG ARG B . n 
B 1 280 ARG 280 288 288 ARG ARG B . n 
B 1 281 ALA 281 289 289 ALA ALA B . n 
B 1 282 CYS 282 290 290 CYS CYS B . n 
B 1 283 GLU 283 291 291 GLU GLU B . n 
B 1 284 VAL 284 292 292 VAL VAL B . n 
B 1 285 LEU 285 293 293 LEU LEU B . n 
B 1 286 THR 286 294 294 THR THR B . n 
B 1 287 GLN 287 295 295 GLN GLN B . n 
B 1 288 LEU 288 296 296 LEU LEU B . n 
B 1 289 LEU 289 297 297 LEU LEU B . n 
B 1 290 ALA 290 298 298 ALA ALA B . n 
B 1 291 LEU 291 299 299 LEU LEU B . n 
B 1 292 GLN 292 300 300 GLN GLN B . n 
B 1 293 LEU 293 301 301 LEU LEU B . n 
B 1 294 SER 294 302 302 SER SER B . n 
B 1 295 ALA 295 303 303 ALA ALA B . n 
B 1 296 GLU 296 304 304 GLU GLU B . n 
B 1 297 GLU 297 305 305 GLU GLU B . n 
B 1 298 ARG 298 306 306 ARG ARG B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EL5 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EL5 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 EL5 1   401 401  EL5 BLA A . 
D 2 EL5 1   401 401  EL5 BLA B . 
E 3 HOH 1   501 55   HOH HOH A . 
E 3 HOH 2   502 130  HOH HOH A . 
E 3 HOH 3   503 529  HOH HOH A . 
E 3 HOH 4   504 255  HOH HOH A . 
E 3 HOH 5   505 282  HOH HOH A . 
E 3 HOH 6   506 174  HOH HOH A . 
E 3 HOH 7   507 286  HOH HOH A . 
E 3 HOH 8   508 182  HOH HOH A . 
E 3 HOH 9   509 1035 HOH HOH A . 
E 3 HOH 10  510 738  HOH HOH A . 
E 3 HOH 11  511 477  HOH HOH A . 
E 3 HOH 12  512 1637 HOH HOH A . 
E 3 HOH 13  513 594  HOH HOH A . 
E 3 HOH 14  514 246  HOH HOH A . 
E 3 HOH 15  515 254  HOH HOH A . 
E 3 HOH 16  516 144  HOH HOH A . 
E 3 HOH 17  517 340  HOH HOH A . 
E 3 HOH 18  518 118  HOH HOH A . 
E 3 HOH 19  519 138  HOH HOH A . 
E 3 HOH 20  520 22   HOH HOH A . 
E 3 HOH 21  521 87   HOH HOH A . 
E 3 HOH 22  522 335  HOH HOH A . 
E 3 HOH 23  523 5    HOH HOH A . 
E 3 HOH 24  524 1    HOH HOH A . 
E 3 HOH 25  525 17   HOH HOH A . 
E 3 HOH 26  526 92   HOH HOH A . 
E 3 HOH 27  527 11   HOH HOH A . 
E 3 HOH 28  528 60   HOH HOH A . 
E 3 HOH 29  529 236  HOH HOH A . 
E 3 HOH 30  530 1080 HOH HOH A . 
E 3 HOH 31  531 71   HOH HOH A . 
E 3 HOH 32  532 1388 HOH HOH A . 
E 3 HOH 33  533 964  HOH HOH A . 
E 3 HOH 34  534 105  HOH HOH A . 
E 3 HOH 35  535 73   HOH HOH A . 
E 3 HOH 36  536 15   HOH HOH A . 
E 3 HOH 37  537 223  HOH HOH A . 
E 3 HOH 38  538 34   HOH HOH A . 
E 3 HOH 39  539 136  HOH HOH A . 
E 3 HOH 40  540 310  HOH HOH A . 
E 3 HOH 41  541 395  HOH HOH A . 
E 3 HOH 42  542 212  HOH HOH A . 
E 3 HOH 43  543 53   HOH HOH A . 
E 3 HOH 44  544 81   HOH HOH A . 
E 3 HOH 45  545 23   HOH HOH A . 
E 3 HOH 46  546 16   HOH HOH A . 
E 3 HOH 47  547 119  HOH HOH A . 
E 3 HOH 48  548 110  HOH HOH A . 
E 3 HOH 49  549 338  HOH HOH A . 
E 3 HOH 50  550 447  HOH HOH A . 
E 3 HOH 51  551 139  HOH HOH A . 
E 3 HOH 52  552 3    HOH HOH A . 
E 3 HOH 53  553 36   HOH HOH A . 
E 3 HOH 54  554 38   HOH HOH A . 
E 3 HOH 55  555 1359 HOH HOH A . 
E 3 HOH 56  556 1583 HOH HOH A . 
E 3 HOH 57  557 91   HOH HOH A . 
E 3 HOH 58  558 26   HOH HOH A . 
E 3 HOH 59  559 344  HOH HOH A . 
E 3 HOH 60  560 21   HOH HOH A . 
E 3 HOH 61  561 127  HOH HOH A . 
E 3 HOH 62  562 364  HOH HOH A . 
E 3 HOH 63  563 39   HOH HOH A . 
E 3 HOH 64  564 42   HOH HOH A . 
E 3 HOH 65  565 100  HOH HOH A . 
E 3 HOH 66  566 90   HOH HOH A . 
E 3 HOH 67  567 164  HOH HOH A . 
E 3 HOH 68  568 1553 HOH HOH A . 
E 3 HOH 69  569 124  HOH HOH A . 
E 3 HOH 70  570 123  HOH HOH A . 
E 3 HOH 71  571 46   HOH HOH A . 
E 3 HOH 72  572 44   HOH HOH A . 
E 3 HOH 73  573 28   HOH HOH A . 
E 3 HOH 74  574 122  HOH HOH A . 
E 3 HOH 75  575 116  HOH HOH A . 
E 3 HOH 76  576 261  HOH HOH A . 
E 3 HOH 77  577 163  HOH HOH A . 
E 3 HOH 78  578 262  HOH HOH A . 
E 3 HOH 79  579 168  HOH HOH A . 
E 3 HOH 80  580 129  HOH HOH A . 
E 3 HOH 81  581 41   HOH HOH A . 
E 3 HOH 82  582 305  HOH HOH A . 
E 3 HOH 83  583 207  HOH HOH A . 
E 3 HOH 84  584 6    HOH HOH A . 
E 3 HOH 85  585 252  HOH HOH A . 
E 3 HOH 86  586 145  HOH HOH A . 
E 3 HOH 87  587 47   HOH HOH A . 
E 3 HOH 88  588 180  HOH HOH A . 
E 3 HOH 89  589 249  HOH HOH A . 
E 3 HOH 90  590 179  HOH HOH A . 
E 3 HOH 91  591 161  HOH HOH A . 
E 3 HOH 92  592 504  HOH HOH A . 
E 3 HOH 93  593 14   HOH HOH A . 
E 3 HOH 94  594 154  HOH HOH A . 
E 3 HOH 95  595 121  HOH HOH A . 
E 3 HOH 96  596 234  HOH HOH A . 
E 3 HOH 97  597 132  HOH HOH A . 
E 3 HOH 98  598 191  HOH HOH A . 
E 3 HOH 99  599 20   HOH HOH A . 
E 3 HOH 100 600 1169 HOH HOH A . 
E 3 HOH 101 601 257  HOH HOH A . 
E 3 HOH 102 602 248  HOH HOH A . 
E 3 HOH 103 603 185  HOH HOH A . 
E 3 HOH 104 604 238  HOH HOH A . 
E 3 HOH 105 605 265  HOH HOH A . 
E 3 HOH 106 606 166  HOH HOH A . 
E 3 HOH 107 607 303  HOH HOH A . 
E 3 HOH 108 608 59   HOH HOH A . 
E 3 HOH 109 609 106  HOH HOH A . 
E 3 HOH 110 610 125  HOH HOH A . 
E 3 HOH 111 611 75   HOH HOH A . 
E 3 HOH 112 612 48   HOH HOH A . 
E 3 HOH 113 613 235  HOH HOH A . 
E 3 HOH 114 614 242  HOH HOH A . 
E 3 HOH 115 615 66   HOH HOH A . 
E 3 HOH 116 616 381  HOH HOH A . 
E 3 HOH 117 617 2    HOH HOH A . 
E 3 HOH 118 618 549  HOH HOH A . 
E 3 HOH 119 619 258  HOH HOH A . 
E 3 HOH 120 620 290  HOH HOH A . 
E 3 HOH 121 621 169  HOH HOH A . 
E 3 HOH 122 622 218  HOH HOH A . 
E 3 HOH 123 623 50   HOH HOH A . 
E 3 HOH 124 624 86   HOH HOH A . 
E 3 HOH 125 625 95   HOH HOH A . 
E 3 HOH 126 626 99   HOH HOH A . 
E 3 HOH 127 627 187  HOH HOH A . 
E 3 HOH 128 628 924  HOH HOH A . 
E 3 HOH 129 629 27   HOH HOH A . 
E 3 HOH 130 630 1336 HOH HOH A . 
E 3 HOH 131 631 153  HOH HOH A . 
E 3 HOH 132 632 444  HOH HOH A . 
E 3 HOH 133 633 224  HOH HOH A . 
E 3 HOH 134 634 291  HOH HOH A . 
E 3 HOH 135 635 189  HOH HOH A . 
E 3 HOH 136 636 239  HOH HOH A . 
E 3 HOH 137 637 131  HOH HOH A . 
E 3 HOH 138 638 220  HOH HOH A . 
E 3 HOH 139 639 739  HOH HOH A . 
E 3 HOH 140 640 1155 HOH HOH A . 
E 3 HOH 141 641 240  HOH HOH A . 
E 3 HOH 142 642 213  HOH HOH A . 
E 3 HOH 143 643 222  HOH HOH A . 
E 3 HOH 144 644 151  HOH HOH A . 
E 3 HOH 145 645 256  HOH HOH A . 
E 3 HOH 146 646 62   HOH HOH A . 
E 3 HOH 147 647 275  HOH HOH A . 
E 3 HOH 148 648 521  HOH HOH A . 
E 3 HOH 149 649 167  HOH HOH A . 
E 3 HOH 150 650 160  HOH HOH A . 
E 3 HOH 151 651 190  HOH HOH A . 
E 3 HOH 152 652 206  HOH HOH A . 
E 3 HOH 153 653 83   HOH HOH A . 
E 3 HOH 154 654 932  HOH HOH A . 
E 3 HOH 155 655 380  HOH HOH A . 
E 3 HOH 156 656 178  HOH HOH A . 
E 3 HOH 157 657 217  HOH HOH A . 
E 3 HOH 158 658 1174 HOH HOH A . 
E 3 HOH 159 659 141  HOH HOH A . 
E 3 HOH 160 660 1367 HOH HOH A . 
E 3 HOH 161 661 604  HOH HOH A . 
E 3 HOH 162 662 245  HOH HOH A . 
E 3 HOH 163 663 376  HOH HOH A . 
E 3 HOH 164 664 465  HOH HOH A . 
E 3 HOH 165 665 173  HOH HOH A . 
E 3 HOH 166 666 233  HOH HOH A . 
E 3 HOH 167 667 80   HOH HOH A . 
E 3 HOH 168 668 126  HOH HOH A . 
E 3 HOH 169 669 216  HOH HOH A . 
E 3 HOH 170 670 1378 HOH HOH A . 
E 3 HOH 171 671 243  HOH HOH A . 
E 3 HOH 172 672 49   HOH HOH A . 
E 3 HOH 173 673 186  HOH HOH A . 
E 3 HOH 174 674 227  HOH HOH A . 
E 3 HOH 175 675 198  HOH HOH A . 
E 3 HOH 176 676 459  HOH HOH A . 
E 3 HOH 177 677 1344 HOH HOH A . 
E 3 HOH 178 678 476  HOH HOH A . 
E 3 HOH 179 679 72   HOH HOH A . 
E 3 HOH 180 680 133  HOH HOH A . 
E 3 HOH 181 681 462  HOH HOH A . 
E 3 HOH 182 682 226  HOH HOH A . 
E 3 HOH 183 683 203  HOH HOH A . 
E 3 HOH 184 684 300  HOH HOH A . 
E 3 HOH 185 685 390  HOH HOH A . 
E 3 HOH 186 686 231  HOH HOH A . 
E 3 HOH 187 687 128  HOH HOH A . 
E 3 HOH 188 688 510  HOH HOH A . 
E 3 HOH 189 689 201  HOH HOH A . 
E 3 HOH 190 690 679  HOH HOH A . 
E 3 HOH 191 691 489  HOH HOH A . 
E 3 HOH 192 692 93   HOH HOH A . 
E 3 HOH 193 693 962  HOH HOH A . 
E 3 HOH 194 694 165  HOH HOH A . 
E 3 HOH 195 695 356  HOH HOH A . 
E 3 HOH 196 696 241  HOH HOH A . 
E 3 HOH 197 697 194  HOH HOH A . 
E 3 HOH 198 698 176  HOH HOH A . 
E 3 HOH 199 699 442  HOH HOH A . 
E 3 HOH 200 700 192  HOH HOH A . 
E 3 HOH 201 701 565  HOH HOH A . 
F 3 HOH 1   501 97   HOH HOH B . 
F 3 HOH 2   502 135  HOH HOH B . 
F 3 HOH 3   503 104  HOH HOH B . 
F 3 HOH 4   504 485  HOH HOH B . 
F 3 HOH 5   505 195  HOH HOH B . 
F 3 HOH 6   506 193  HOH HOH B . 
F 3 HOH 7   507 188  HOH HOH B . 
F 3 HOH 8   508 159  HOH HOH B . 
F 3 HOH 9   509 112  HOH HOH B . 
F 3 HOH 10  510 284  HOH HOH B . 
F 3 HOH 11  511 299  HOH HOH B . 
F 3 HOH 12  512 69   HOH HOH B . 
F 3 HOH 13  513 273  HOH HOH B . 
F 3 HOH 14  514 170  HOH HOH B . 
F 3 HOH 15  515 260  HOH HOH B . 
F 3 HOH 16  516 140  HOH HOH B . 
F 3 HOH 17  517 279  HOH HOH B . 
F 3 HOH 18  518 572  HOH HOH B . 
F 3 HOH 19  519 508  HOH HOH B . 
F 3 HOH 20  520 78   HOH HOH B . 
F 3 HOH 21  521 149  HOH HOH B . 
F 3 HOH 22  522 285  HOH HOH B . 
F 3 HOH 23  523 272  HOH HOH B . 
F 3 HOH 24  524 37   HOH HOH B . 
F 3 HOH 25  525 18   HOH HOH B . 
F 3 HOH 26  526 24   HOH HOH B . 
F 3 HOH 27  527 117  HOH HOH B . 
F 3 HOH 28  528 225  HOH HOH B . 
F 3 HOH 29  529 10   HOH HOH B . 
F 3 HOH 30  530 4    HOH HOH B . 
F 3 HOH 31  531 51   HOH HOH B . 
F 3 HOH 32  532 109  HOH HOH B . 
F 3 HOH 33  533 13   HOH HOH B . 
F 3 HOH 34  534 29   HOH HOH B . 
F 3 HOH 35  535 77   HOH HOH B . 
F 3 HOH 36  536 96   HOH HOH B . 
F 3 HOH 37  537 9    HOH HOH B . 
F 3 HOH 38  538 8    HOH HOH B . 
F 3 HOH 39  539 111  HOH HOH B . 
F 3 HOH 40  540 288  HOH HOH B . 
F 3 HOH 41  541 40   HOH HOH B . 
F 3 HOH 42  542 7    HOH HOH B . 
F 3 HOH 43  543 306  HOH HOH B . 
F 3 HOH 44  544 57   HOH HOH B . 
F 3 HOH 45  545 102  HOH HOH B . 
F 3 HOH 46  546 89   HOH HOH B . 
F 3 HOH 47  547 277  HOH HOH B . 
F 3 HOH 48  548 209  HOH HOH B . 
F 3 HOH 49  549 94   HOH HOH B . 
F 3 HOH 50  550 1241 HOH HOH B . 
F 3 HOH 51  551 134  HOH HOH B . 
F 3 HOH 52  552 68   HOH HOH B . 
F 3 HOH 53  553 30   HOH HOH B . 
F 3 HOH 54  554 114  HOH HOH B . 
F 3 HOH 55  555 202  HOH HOH B . 
F 3 HOH 56  556 270  HOH HOH B . 
F 3 HOH 57  557 156  HOH HOH B . 
F 3 HOH 58  558 268  HOH HOH B . 
F 3 HOH 59  559 148  HOH HOH B . 
F 3 HOH 60  560 56   HOH HOH B . 
F 3 HOH 61  561 498  HOH HOH B . 
F 3 HOH 62  562 33   HOH HOH B . 
F 3 HOH 63  563 247  HOH HOH B . 
F 3 HOH 64  564 280  HOH HOH B . 
F 3 HOH 65  565 19   HOH HOH B . 
F 3 HOH 66  566 25   HOH HOH B . 
F 3 HOH 67  567 84   HOH HOH B . 
F 3 HOH 68  568 31   HOH HOH B . 
F 3 HOH 69  569 157  HOH HOH B . 
F 3 HOH 70  570 32   HOH HOH B . 
F 3 HOH 71  571 115  HOH HOH B . 
F 3 HOH 72  572 52   HOH HOH B . 
F 3 HOH 73  573 143  HOH HOH B . 
F 3 HOH 74  574 152  HOH HOH B . 
F 3 HOH 75  575 82   HOH HOH B . 
F 3 HOH 76  576 64   HOH HOH B . 
F 3 HOH 77  577 162  HOH HOH B . 
F 3 HOH 78  578 175  HOH HOH B . 
F 3 HOH 79  579 107  HOH HOH B . 
F 3 HOH 80  580 274  HOH HOH B . 
F 3 HOH 81  581 147  HOH HOH B . 
F 3 HOH 82  582 200  HOH HOH B . 
F 3 HOH 83  583 108  HOH HOH B . 
F 3 HOH 84  584 58   HOH HOH B . 
F 3 HOH 85  585 158  HOH HOH B . 
F 3 HOH 86  586 76   HOH HOH B . 
F 3 HOH 87  587 208  HOH HOH B . 
F 3 HOH 88  588 171  HOH HOH B . 
F 3 HOH 89  589 146  HOH HOH B . 
F 3 HOH 90  590 263  HOH HOH B . 
F 3 HOH 91  591 35   HOH HOH B . 
F 3 HOH 92  592 726  HOH HOH B . 
F 3 HOH 93  593 43   HOH HOH B . 
F 3 HOH 94  594 734  HOH HOH B . 
F 3 HOH 95  595 196  HOH HOH B . 
F 3 HOH 96  596 244  HOH HOH B . 
F 3 HOH 97  597 1635 HOH HOH B . 
F 3 HOH 98  598 690  HOH HOH B . 
F 3 HOH 99  599 172  HOH HOH B . 
F 3 HOH 100 600 142  HOH HOH B . 
F 3 HOH 101 601 266  HOH HOH B . 
F 3 HOH 102 602 183  HOH HOH B . 
F 3 HOH 103 603 214  HOH HOH B . 
F 3 HOH 104 604 184  HOH HOH B . 
F 3 HOH 105 605 210  HOH HOH B . 
F 3 HOH 106 606 229  HOH HOH B . 
F 3 HOH 107 607 45   HOH HOH B . 
F 3 HOH 108 608 333  HOH HOH B . 
F 3 HOH 109 609 933  HOH HOH B . 
F 3 HOH 110 610 197  HOH HOH B . 
F 3 HOH 111 611 181  HOH HOH B . 
F 3 HOH 112 612 228  HOH HOH B . 
F 3 HOH 113 613 70   HOH HOH B . 
F 3 HOH 114 614 276  HOH HOH B . 
F 3 HOH 115 615 205  HOH HOH B . 
F 3 HOH 116 616 63   HOH HOH B . 
F 3 HOH 117 617 1466 HOH HOH B . 
F 3 HOH 118 618 137  HOH HOH B . 
F 3 HOH 119 619 103  HOH HOH B . 
F 3 HOH 120 620 253  HOH HOH B . 
F 3 HOH 121 621 259  HOH HOH B . 
F 3 HOH 122 622 665  HOH HOH B . 
F 3 HOH 123 623 296  HOH HOH B . 
F 3 HOH 124 624 61   HOH HOH B . 
F 3 HOH 125 625 12   HOH HOH B . 
F 3 HOH 126 626 673  HOH HOH B . 
F 3 HOH 127 627 815  HOH HOH B . 
F 3 HOH 128 628 602  HOH HOH B . 
F 3 HOH 129 629 383  HOH HOH B . 
F 3 HOH 130 630 54   HOH HOH B . 
F 3 HOH 131 631 1552 HOH HOH B . 
F 3 HOH 132 632 1521 HOH HOH B . 
F 3 HOH 133 633 65   HOH HOH B . 
F 3 HOH 134 634 294  HOH HOH B . 
F 3 HOH 135 635 98   HOH HOH B . 
F 3 HOH 136 636 230  HOH HOH B . 
F 3 HOH 137 637 271  HOH HOH B . 
F 3 HOH 138 638 705  HOH HOH B . 
F 3 HOH 139 639 404  HOH HOH B . 
F 3 HOH 140 640 349  HOH HOH B . 
F 3 HOH 141 641 199  HOH HOH B . 
F 3 HOH 142 642 101  HOH HOH B . 
F 3 HOH 143 643 215  HOH HOH B . 
F 3 HOH 144 644 473  HOH HOH B . 
F 3 HOH 145 645 232  HOH HOH B . 
F 3 HOH 146 646 817  HOH HOH B . 
F 3 HOH 147 647 211  HOH HOH B . 
F 3 HOH 148 648 79   HOH HOH B . 
F 3 HOH 149 649 1102 HOH HOH B . 
F 3 HOH 150 650 926  HOH HOH B . 
F 3 HOH 151 651 267  HOH HOH B . 
F 3 HOH 152 652 177  HOH HOH B . 
F 3 HOH 153 653 264  HOH HOH B . 
F 3 HOH 154 654 269  HOH HOH B . 
F 3 HOH 155 655 519  HOH HOH B . 
F 3 HOH 156 656 1129 HOH HOH B . 
F 3 HOH 157 657 85   HOH HOH B . 
F 3 HOH 158 658 1361 HOH HOH B . 
F 3 HOH 159 659 298  HOH HOH B . 
F 3 HOH 160 660 120  HOH HOH B . 
F 3 HOH 161 661 866  HOH HOH B . 
F 3 HOH 162 662 251  HOH HOH B . 
F 3 HOH 163 663 475  HOH HOH B . 
F 3 HOH 164 664 74   HOH HOH B . 
F 3 HOH 165 665 219  HOH HOH B . 
F 3 HOH 166 666 698  HOH HOH B . 
F 3 HOH 167 667 150  HOH HOH B . 
F 3 HOH 168 668 67   HOH HOH B . 
F 3 HOH 169 669 599  HOH HOH B . 
F 3 HOH 170 670 1323 HOH HOH B . 
F 3 HOH 171 671 237  HOH HOH B . 
F 3 HOH 172 672 950  HOH HOH B . 
F 3 HOH 173 673 204  HOH HOH B . 
F 3 HOH 174 674 113  HOH HOH B . 
F 3 HOH 175 675 503  HOH HOH B . 
F 3 HOH 176 676 88   HOH HOH B . 
F 3 HOH 177 677 250  HOH HOH B . 
F 3 HOH 178 678 155  HOH HOH B . 
F 3 HOH 179 679 221  HOH HOH B . 
F 3 HOH 180 680 1353 HOH HOH B . 
F 3 HOH 181 681 1057 HOH HOH B . 
F 3 HOH 182 682 640  HOH HOH B . 
F 3 HOH 183 683 363  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_reference_DOI 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.21_5207 ? 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? iMOSFLM ? ? ? .         ? 2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .         ? 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .         ? 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9NAA 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     60.760 
_cell.length_a_esd                 ? 
_cell.length_b                     101.140 
_cell.length_b_esd                 ? 
_cell.length_c                     103.440 
_cell.length_c_esd                 ? 
_cell.volume                       635666.356 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9NAA 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9NAA 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.45 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.87 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          MICROBATCH 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M TAPS, 0.1 M Mg(NO3)2, 24% PEG 20000, pH 9' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     110 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-08-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.873 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.873 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-2 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          39.7 
_reflns.entry_id                                       9NAA 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.1 
_reflns.d_resolution_low                               38.87 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     35675 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.994 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.089 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.1 
_reflns_shell.d_res_low                                     2.13 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.0 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2963 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.62 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          97.6 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.11 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.14 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9NAA 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             38.87 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     35585 
_refine.ls_number_reflns_R_free                  3343 
_refine.ls_number_reflns_R_work                  62286 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    91.33 
_refine.ls_percent_reflns_R_free                 5.09 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2290 
_refine.ls_R_factor_R_free                       0.2602 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2273 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.01 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.6083 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2808 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10 
_refine_hist.d_res_low                        38.87 
_refine_hist.number_atoms_solvent             384 
_refine_hist.number_atoms_total               4724 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4254 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         86 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_Zscore 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0081  ? 4436 ? f_bond_d           ? ? ? 
'X-RAY DIFFRACTION' ? 1.1356  ? 6053 ? f_angle_d          ? ? ? 
'X-RAY DIFFRACTION' ? 0.0526  ? 687  ? f_chiral_restr     ? ? ? 
'X-RAY DIFFRACTION' ? 0.0097  ? 790  ? f_plane_restr      ? ? ? 
'X-RAY DIFFRACTION' ? 19.1123 ? 1647 ? f_dihedral_angle_d ? ? ? 
# 
_refine_ls_restr_ncs.pdbx_ordinal        1 
_refine_ls_restr_ncs.pdbx_refine_id      'X-RAY DIFFRACTION' 
_refine_ls_restr_ncs.dom_id              d_2 
_refine_ls_restr_ncs.pdbx_ens_id         ens_1 
_refine_ls_restr_ncs.rms_dev_position    0.985212528032 
_refine_ls_restr_ncs.weight_position     ? 
_refine_ls_restr_ncs.rms_dev_B_iso       ? 
_refine_ls_restr_ncs.weight_B_iso        ? 
_refine_ls_restr_ncs.pdbx_type           'Torsion NCS' 
_refine_ls_restr_ncs.pdbx_asym_id        A 
_refine_ls_restr_ncs.pdbx_auth_asym_id   A 
_refine_ls_restr_ncs.pdbx_number         ? 
_refine_ls_restr_ncs.pdbx_rms            ? 
_refine_ls_restr_ncs.pdbx_weight         ? 
_refine_ls_restr_ncs.ncs_model_details   ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10 2.13  . . 140 2632 93.24 . . . . 0.4099 . . . . . . . . . . . . . . . 0.4662 
'X-RAY DIFFRACTION' 2.13 2.16  . . 116 2710 94.26 . . . . 0.3893 . . . . . . . . . . . . . . . 0.4491 
'X-RAY DIFFRACTION' 2.16 2.20  . . 173 2635 93.57 . . . . 0.3750 . . . . . . . . . . . . . . . 0.3923 
'X-RAY DIFFRACTION' 2.20 2.23  . . 144 2637 93.83 . . . . 0.3509 . . . . . . . . . . . . . . . 0.3344 
'X-RAY DIFFRACTION' 2.23 2.27  . . 153 2652 92.76 . . . . 0.3458 . . . . . . . . . . . . . . . 0.3849 
'X-RAY DIFFRACTION' 2.27 2.31  . . 121 2680 93.27 . . . . 0.3318 . . . . . . . . . . . . . . . 0.3346 
'X-RAY DIFFRACTION' 2.31 2.36  . . 153 2634 92.71 . . . . 0.3173 . . . . . . . . . . . . . . . 0.3638 
'X-RAY DIFFRACTION' 2.36 2.40  . . 138 2635 92.90 . . . . 0.3007 . . . . . . . . . . . . . . . 0.3097 
'X-RAY DIFFRACTION' 2.40 2.46  . . 112 2664 92.60 . . . . 0.2861 . . . . . . . . . . . . . . . 0.3527 
'X-RAY DIFFRACTION' 2.46 2.51  . . 132 2599 91.61 . . . . 0.2874 . . . . . . . . . . . . . . . 0.4077 
'X-RAY DIFFRACTION' 2.51 2.58  . . 152 2576 90.96 . . . . 0.2723 . . . . . . . . . . . . . . . 0.2919 
'X-RAY DIFFRACTION' 2.58 2.65  . . 155 2535 89.40 . . . . 0.2733 . . . . . . . . . . . . . . . 0.3018 
'X-RAY DIFFRACTION' 2.65 2.72  . . 160 2549 91.00 . . . . 0.2569 . . . . . . . . . . . . . . . 0.2467 
'X-RAY DIFFRACTION' 2.72 2.81  . . 151 2622 92.65 . . . . 0.2556 . . . . . . . . . . . . . . . 0.3100 
'X-RAY DIFFRACTION' 2.81 2.91  . . 145 2633 92.63 . . . . 0.2349 . . . . . . . . . . . . . . . 0.2585 
'X-RAY DIFFRACTION' 2.91 3.03  . . 143 2639 92.39 . . . . 0.2281 . . . . . . . . . . . . . . . 0.2903 
'X-RAY DIFFRACTION' 3.03 3.17  . . 142 2595 91.81 . . . . 0.2171 . . . . . . . . . . . . . . . 0.2458 
'X-RAY DIFFRACTION' 3.17 3.33  . . 154 2599 91.71 . . . . 0.2069 . . . . . . . . . . . . . . . 0.2607 
'X-RAY DIFFRACTION' 3.33 3.54  . . 127 2576 90.80 . . . . 0.1908 . . . . . . . . . . . . . . . 0.2114 
'X-RAY DIFFRACTION' 3.54 3.81  . . 144 2576 90.88 . . . . 0.1831 . . . . . . . . . . . . . . . 0.2294 
'X-RAY DIFFRACTION' 3.82 4.20  . . 149 2514 89.09 . . . . 0.1815 . . . . . . . . . . . . . . . 0.2161 
'X-RAY DIFFRACTION' 4.20 4.80  . . 121 2490 87.09 . . . . 0.1667 . . . . . . . . . . . . . . . 0.1594 
'X-RAY DIFFRACTION' 4.81 6.05  . . 121 2466 85.92 . . . . 0.2004 . . . . . . . . . . . . . . . 0.2573 
'X-RAY DIFFRACTION' 6.05 38.87 . . 97  2438 85.04 . . . . 0.1882 . . . . . . . . . . . . . . . 0.2002 
# 
_struct_ncs_oper.id             1 
_struct_ncs_oper.code           given 
_struct_ncs_oper.matrix[1][1]   -0.999936129899 
_struct_ncs_oper.matrix[1][2]   -0.0108053239384 
_struct_ncs_oper.matrix[1][3]   -0.00331377371132 
_struct_ncs_oper.matrix[2][1]   0.0108079738086 
_struct_ncs_oper.matrix[2][2]   -0.999941285747 
_struct_ncs_oper.matrix[2][3]   -0.000782790429716 
_struct_ncs_oper.matrix[3][1]   -0.0033051208414 
_struct_ncs_oper.matrix[3][2]   -0.000818555612292 
_struct_ncs_oper.matrix[3][3]   0.999994203055 
_struct_ncs_oper.vector[1]      0.494708773602 
_struct_ncs_oper.vector[2]      -8.80977555242 
_struct_ncs_oper.vector[3]      0.0160725688642 
_struct_ncs_oper.details        ? 
# 
loop_
_struct_ncs_dom.pdbx_ens_id 
_struct_ncs_dom.id 
_struct_ncs_dom.details 
ens_1 d_1 
;(chain "A" and (resid 9 through 115 or resid 137 through 306 or resid 401))
;
ens_1 d_2 
;chain "B"
;
# 
loop_
_struct_ncs_dom_lim.pdbx_ens_id 
_struct_ncs_dom_lim.dom_id 
_struct_ncs_dom_lim.pdbx_component_id 
_struct_ncs_dom_lim.beg_label_asym_id 
_struct_ncs_dom_lim.beg_label_comp_id 
_struct_ncs_dom_lim.beg_label_seq_id 
_struct_ncs_dom_lim.beg_label_alt_id 
_struct_ncs_dom_lim.end_label_asym_id 
_struct_ncs_dom_lim.end_label_comp_id 
_struct_ncs_dom_lim.end_label_seq_id 
_struct_ncs_dom_lim.end_label_alt_id 
_struct_ncs_dom_lim.beg_auth_asym_id 
_struct_ncs_dom_lim.beg_auth_comp_id 
_struct_ncs_dom_lim.beg_auth_seq_id 
_struct_ncs_dom_lim.end_auth_asym_id 
_struct_ncs_dom_lim.end_auth_comp_id 
_struct_ncs_dom_lim.end_auth_seq_id 
_struct_ncs_dom_lim.pdbx_refine_code 
_struct_ncs_dom_lim.selection_details 
ens_1 d_1 1 A ASP 1   . A PRO 107 . A ASP 9   A PRO 115 ? ? 
ens_1 d_1 2 A GLY 129 . A ARG 298 . A GLY 137 A ARG 306 ? ? 
ens_1 d_1 3 C BLA .   . C BLA .   . A BLA 401 A BLA 401 ? ? 
ens_1 d_2 1 B ASP 1   . B ARG 298 . B ASP 9   B ARG 306 ? ? 
ens_1 d_2 2 D BLA .   . D BLA .   . B BLA 401 B BLA 401 ? ? 
# 
_struct_ncs_ens.id        ens_1 
_struct_ncs_ens.details   ? 
# 
_struct_ncs_ens_gen.ens_id     ens_1 
_struct_ncs_ens_gen.dom_id_1   d_2 
_struct_ncs_ens_gen.dom_id_2   d_1 
_struct_ncs_ens_gen.oper_id    1 
# 
_struct.entry_id                     9NAA 
_struct.title                        'Unusual structure of a bacteriophytochrome fragment derived from full length SaBphP2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9NAA 
_struct_keywords.text            'phytochrome, myxobacteria, biliverdin, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q09E27_STIAD 
_struct_ref.pdbx_db_accession          Q09E27 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;DLSQCDREPIHLLGGIQSHGVLLAFRGPDRLLEVVSANAQALLGRPPETLLGQPVGRVLPAEVLAQWEPLVARGSVRVVL
PAGAYRALLHESDGLTVLELEPAELQPGMEETALEVVRRLVSPLAGVKGTQALLQTAADTVRALTGFDRVMVYRFDADWH
GEVLAESKRGGMDGFLGMHFPATDIPVQARALYTRNPLRLIADARARPVPLLPPVVPALGRPLDLSNSALRSVSPVHLEY
LRNMGVGASFSLSLLKEGVLWGLIACHHLEPLHISHERRRACEVLTQLLALQLSAEER
;
_struct_ref.pdbx_align_begin           9 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9NAA A 1 ? 298 ? Q09E27 9 ? 306 ? 9 306 
2 1 9NAA B 1 ? 298 ? Q09E27 9 ? 306 ? 9 306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9NAA ASP A 108 ? UNP Q09E27 GLY 116 conflict 116 1 
2 9NAA ASP B 108 ? UNP Q09E27 GLY 116 conflict 116 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1360  ? 
1 MORE         -13   ? 
1 'SSA (A^2)'  23710 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z           1.0  0.0 0.0 0.0 0.0 1.0 0.0 0.0           0.0 0.0 1.0  0.0           
2 'point symmetry operation' 3_555 -x,y+1/2,-z+1/2 -1.0 0.0 0.0 0.0 0.0 1.0 0.0 50.6395000000 0.0 0.0 -1.0 51.6950000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LEU A 2   ? ARG A 7   ? LEU A 10  ARG A 15  1 ? 6  
HELX_P HELX_P2  AA2 ALA A 39  ? GLY A 44  ? ALA A 47  GLY A 52  1 ? 6  
HELX_P HELX_P3  AA3 PRO A 46  ? LEU A 51  ? PRO A 54  LEU A 59  1 ? 6  
HELX_P HELX_P4  AA4 PRO A 54  ? VAL A 58  ? PRO A 62  VAL A 66  5 ? 5  
HELX_P HELX_P5  AA5 PRO A 60  ? GLN A 66  ? PRO A 68  GLN A 74  1 ? 7  
HELX_P HELX_P6  AA6 GLN A 66  ? GLY A 74  ? GLN A 74  GLY A 82  1 ? 9  
HELX_P HELX_P7  AA7 THR A 130 ? GLY A 146 ? THR A 138 GLY A 154 1 ? 17 
HELX_P HELX_P8  AA8 PRO A 186 ? ASN A 196 ? PRO A 194 ASN A 204 1 ? 11 
HELX_P HELX_P9  AA9 SER A 234 ? MET A 244 ? SER A 242 MET A 252 1 ? 11 
HELX_P HELX_P10 AB1 SER A 275 ? GLU A 296 ? SER A 283 GLU A 304 1 ? 22 
HELX_P HELX_P11 AB2 ALA B 39  ? GLY B 44  ? ALA B 47  GLY B 52  1 ? 6  
HELX_P HELX_P12 AB3 PRO B 46  ? LEU B 51  ? PRO B 54  LEU B 59  1 ? 6  
HELX_P HELX_P13 AB4 PRO B 54  ? VAL B 58  ? PRO B 62  VAL B 66  5 ? 5  
HELX_P HELX_P14 AB5 PRO B 60  ? GLN B 66  ? PRO B 68  GLN B 74  1 ? 7  
HELX_P HELX_P15 AB6 GLN B 66  ? GLY B 74  ? GLN B 74  GLY B 82  1 ? 9  
HELX_P HELX_P16 AB7 THR B 130 ? GLY B 146 ? THR B 138 GLY B 154 1 ? 17 
HELX_P HELX_P17 AB8 PRO B 186 ? ASN B 196 ? PRO B 194 ASN B 204 1 ? 11 
HELX_P HELX_P18 AB9 SER B 234 ? MET B 244 ? SER B 242 MET B 252 1 ? 11 
HELX_P HELX_P19 AC1 SER B 275 ? GLU B 296 ? SER B 283 GLU B 304 1 ? 22 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 5 SG ? ? ? 1_555 C EL5 . CBA ? ? A CYS 13 A EL5 401 1_555 ? ? ? ? ? ? ? 1.686 ? ? 
covale2 covale none ? B CYS 5 SG ? ? ? 1_555 D EL5 . CBA ? ? B CYS 13 B EL5 401 1_555 ? ? ? ? ? ? ? 1.690 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 EL5 C . ? CYS A 5 ? EL5 A 401 ? 1_555 CYS A 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
2 EL5 D . ? CYS B 5 ? EL5 B 401 ? 1_555 CYS B 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LEU 212 A . ? LEU 220 A PRO 213 A ? PRO 221 A 1 -3.20 
2 LEU 212 B . ? LEU 220 B PRO 213 B ? PRO 221 B 1 -3.26 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 7 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 15  ? ILE A 16  ? GLY A 23  ILE A 24  
AA1 2 VAL A 209 ? LEU A 212 ? VAL A 217 LEU A 220 
AA1 3 LEU A 31  ? SER A 36  ? LEU A 39  SER A 44  
AA1 4 VAL A 21  ? ARG A 26  ? VAL A 29  ARG A 34  
AA1 5 LEU A 95  ? PRO A 102 ? LEU A 103 PRO A 110 
AA1 6 GLY A 83  ? SER A 92  ? GLY A 91  SER A 100 
AA1 7 SER A 75  ? LEU A 80  ? SER A 83  LEU A 88  
AA2 1 GLY A 161 ? LYS A 168 ? GLY A 169 LYS A 176 
AA2 2 ARG A 149 ? PHE A 155 ? ARG A 157 PHE A 163 
AA2 3 VAL A 259 ? HIS A 268 ? VAL A 267 HIS A 276 
AA2 4 ALA A 248 ? LYS A 256 ? ALA A 256 LYS A 264 
AA2 5 LEU A 198 ? ILE A 201 ? LEU A 206 ILE A 209 
AA3 1 GLY B 15  ? ILE B 16  ? GLY B 23  ILE B 24  
AA3 2 VAL B 209 ? LEU B 212 ? VAL B 217 LEU B 220 
AA3 3 LEU B 31  ? SER B 36  ? LEU B 39  SER B 44  
AA3 4 VAL B 21  ? ARG B 26  ? VAL B 29  ARG B 34  
AA3 5 LEU B 95  ? PRO B 102 ? LEU B 103 PRO B 110 
AA3 6 GLY B 83  ? SER B 92  ? GLY B 91  SER B 100 
AA3 7 SER B 75  ? LEU B 80  ? SER B 83  LEU B 88  
AA4 1 GLY B 161 ? LYS B 168 ? GLY B 169 LYS B 176 
AA4 2 ARG B 149 ? PHE B 155 ? ARG B 157 PHE B 163 
AA4 3 VAL B 259 ? HIS B 268 ? VAL B 267 HIS B 276 
AA4 4 ALA B 248 ? LYS B 256 ? ALA B 256 LYS B 264 
AA4 5 LEU B 198 ? ILE B 201 ? LEU B 206 ILE B 209 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 16  ? N ILE A 24  O VAL A 209 ? O VAL A 217 
AA1 2 3 O LEU A 212 ? O LEU A 220 N VAL A 35  ? N VAL A 43  
AA1 3 4 O GLU A 33  ? O GLU A 41  N ALA A 24  ? N ALA A 32  
AA1 4 5 N LEU A 23  ? N LEU A 31  O LEU A 98  ? O LEU A 106 
AA1 5 6 O GLU A 101 ? O GLU A 109 N ARG A 86  ? N ARG A 94  
AA1 6 7 O TYR A 85  ? O TYR A 93  N VAL A 78  ? N VAL A 86  
AA2 1 2 O LEU A 164 ? O LEU A 172 N VAL A 152 ? N VAL A 160 
AA2 2 3 N TYR A 153 ? N TYR A 161 O LEU A 263 ? O LEU A 271 
AA2 3 4 O TRP A 261 ? O TRP A 269 N LEU A 254 ? N LEU A 262 
AA2 4 5 O SER A 249 ? O SER A 257 N ILE A 201 ? N ILE A 209 
AA3 1 2 N ILE B 16  ? N ILE B 24  O VAL B 209 ? O VAL B 217 
AA3 2 3 O LEU B 212 ? O LEU B 220 N VAL B 35  ? N VAL B 43  
AA3 3 4 O GLU B 33  ? O GLU B 41  N ALA B 24  ? N ALA B 32  
AA3 4 5 N LEU B 23  ? N LEU B 31  O LEU B 98  ? O LEU B 106 
AA3 5 6 O VAL B 97  ? O VAL B 105 N HIS B 90  ? N HIS B 98  
AA3 6 7 O TYR B 85  ? O TYR B 93  N VAL B 78  ? N VAL B 86  
AA4 1 2 O LEU B 164 ? O LEU B 172 N VAL B 152 ? N VAL B 160 
AA4 2 3 N TYR B 153 ? N TYR B 161 O LEU B 263 ? O LEU B 271 
AA4 3 4 O ILE B 264 ? O ILE B 272 N LEU B 252 ? N LEU B 260 
AA4 4 5 O SER B 249 ? O SER B 257 N ILE B 201 ? N ILE B 209 
# 
_pdbx_entry_details.entry_id                   9NAA 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 OG  A SER 302 ? ? O A HOH 501 ? ? 1.71 
2  1 O   B HOH 554 ? ? O B HOH 611 ? ? 1.75 
3  1 O   B HOH 576 ? ? O B HOH 633 ? ? 1.78 
4  1 O   A HOH 666 ? ? O B HOH 665 ? ? 1.79 
5  1 O   A HOH 626 ? ? O A HOH 680 ? ? 1.89 
6  1 O   B HOH 612 ? ? O B HOH 677 ? ? 1.93 
7  1 OH  B TYR 161 ? ? O B HOH 501 ? ? 1.94 
8  1 O   A HOH 668 ? ? O A HOH 676 ? ? 1.95 
9  1 O   A HOH 617 ? ? O A HOH 676 ? ? 1.95 
10 1 NH2 A ARG 207 ? ? O A HOH 502 ? ? 1.97 
11 1 O2B B EL5 401 ? ? O B HOH 502 ? ? 1.98 
12 1 NH1 A ARG 288 ? ? O A HOH 503 ? ? 1.98 
13 1 O   A HOH 606 ? ? O A HOH 686 ? ? 1.99 
14 1 OG  B SER 302 ? ? O B HOH 503 ? ? 1.99 
15 1 O   A HOH 634 ? ? O A HOH 663 ? ? 2.00 
16 1 NH2 B ARG 207 ? ? O B HOH 502 ? ? 2.02 
17 1 OE2 B GLU 56  ? ? O B HOH 504 ? ? 2.02 
18 1 O   A HOH 522 ? ? O B HOH 543 ? ? 2.03 
19 1 O   B HOH 598 ? ? O B HOH 666 ? ? 2.04 
20 1 O   B HOH 641 ? ? O B HOH 662 ? ? 2.05 
21 1 O   B HOH 615 ? ? O B HOH 647 ? ? 2.06 
22 1 O   B LEU 206 ? ? O B HOH 505 ? ? 2.06 
23 1 O   A HOH 585 ? ? O A HOH 674 ? ? 2.07 
24 1 O   A HOH 656 ? ? O B HOH 657 ? ? 2.09 
25 1 O   B HOH 595 ? ? O B HOH 610 ? ? 2.09 
26 1 OE1 A GLU 109 ? ? O A HOH 504 ? ? 2.09 
27 1 O   A HOH 554 ? ? O A HOH 593 ? ? 2.10 
28 1 O   B HOH 613 ? ? O B HOH 674 ? ? 2.10 
29 1 O   B ARG 81  ? ? O B HOH 506 ? ? 2.11 
30 1 O2B A EL5 401 ? ? O A HOH 502 ? ? 2.11 
31 1 NH1 A ARG 286 ? ? O A HOH 505 ? ? 2.12 
32 1 O   B HOH 634 ? ? O B HOH 637 ? ? 2.12 
33 1 NH2 B ARG 94  ? ? O B HOH 507 ? ? 2.14 
34 1 O   B GLU 70  ? ? O B HOH 508 ? ? 2.14 
35 1 OA  A EL5 401 ? ? O A HOH 506 ? ? 2.18 
36 1 O   B HOH 599 ? ? O B HOH 652 ? ? 2.19 
37 1 O   B HOH 617 ? ? O B HOH 644 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER A 11  ? ? -13.53  -31.35  
2  1 GLN A 74  ? ? -76.69  22.66   
3  1 PRO A 115 ? ? -111.68 -84.50  
4  1 PHE A 183 ? ? 16.54   -129.10 
5  1 ALA A 190 ? ? -85.23  -113.92 
6  1 THR A 191 ? ? -68.70  76.12   
7  1 ASP A 192 ? ? -133.05 -87.79  
8  1 SER A 283 ? ? 91.92   147.02  
9  1 GLU A 305 ? ? -97.29  -75.61  
10 1 LEU B 10  ? ? -142.01 31.92   
11 1 SER B 11  ? ? 135.32  -163.74 
12 1 LEU B 184 ? ? 27.53   83.54   
13 1 ALA B 190 ? ? -91.60  -103.94 
14 1 THR B 191 ? ? -65.10  73.82   
15 1 ASP B 192 ? ? -138.91 -89.97  
16 1 SER B 283 ? ? 91.52   143.63  
17 1 GLU B 305 ? ? -97.28  -76.93  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 700 ? 5.87 . 
2 1 O ? A HOH 701 ? 6.16 . 
3 1 O ? B HOH 681 ? 5.85 . 
4 1 O ? B HOH 682 ? 5.86 . 
5 1 O ? B HOH 683 ? 6.20 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 117 ? A MET 109 
2  1 Y 1 A GLU 118 ? A GLU 110 
3  1 Y 1 A GLU 119 ? A GLU 111 
4  1 Y 1 A THR 120 ? A THR 112 
5  1 Y 1 A ALA 121 ? A ALA 113 
6  1 Y 1 A LEU 122 ? A LEU 114 
7  1 Y 1 A GLU 123 ? A GLU 115 
8  1 Y 1 A VAL 124 ? A VAL 116 
9  1 Y 1 A VAL 125 ? A VAL 117 
10 1 Y 1 A ARG 126 ? A ARG 118 
11 1 Y 1 A ARG 127 ? A ARG 119 
12 1 Y 1 A LEU 128 ? A LEU 120 
13 1 Y 1 A VAL 129 ? A VAL 121 
14 1 Y 1 A SER 130 ? A SER 122 
15 1 Y 1 A PRO 131 ? A PRO 123 
16 1 Y 1 A LEU 132 ? A LEU 124 
17 1 Y 1 A ALA 133 ? A ALA 125 
18 1 Y 1 A GLY 134 ? A GLY 126 
19 1 Y 1 A VAL 135 ? A VAL 127 
20 1 Y 1 A LYS 136 ? A LYS 128 
21 1 Y 1 B ASP 116 ? B ASP 108 
22 1 Y 1 B MET 117 ? B MET 109 
23 1 Y 1 B GLU 118 ? B GLU 110 
24 1 Y 1 B GLU 119 ? B GLU 111 
25 1 Y 1 B THR 120 ? B THR 112 
26 1 Y 1 B ALA 121 ? B ALA 113 
27 1 Y 1 B LEU 122 ? B LEU 114 
28 1 Y 1 B GLU 123 ? B GLU 115 
29 1 Y 1 B VAL 124 ? B VAL 116 
30 1 Y 1 B VAL 125 ? B VAL 117 
31 1 Y 1 B ARG 126 ? B ARG 118 
32 1 Y 1 B ARG 127 ? B ARG 119 
33 1 Y 1 B LEU 128 ? B LEU 120 
34 1 Y 1 B VAL 129 ? B VAL 121 
35 1 Y 1 B SER 130 ? B SER 122 
36 1 Y 1 B PRO 131 ? B PRO 123 
37 1 Y 1 B LEU 132 ? B LEU 124 
38 1 Y 1 B ALA 133 ? B ALA 125 
39 1 Y 1 B GLY 134 ? B GLY 126 
40 1 Y 1 B VAL 135 ? B VAL 127 
41 1 Y 1 B LYS 136 ? B LYS 128 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EL5 C1A  C N N 88  
EL5 C1B  C N N 89  
EL5 O1B  O N N 90  
EL5 C1C  C Y N 91  
EL5 O1C  O N N 92  
EL5 C1D  C N N 93  
EL5 C2A  C N S 94  
EL5 C2B  C N N 95  
EL5 O2B  O N N 96  
EL5 C2C  C Y N 97  
EL5 O2C  O N N 98  
EL5 C2D  C N N 99  
EL5 C3A  C N N 100 
EL5 C3B  C N N 101 
EL5 C3C  C Y N 102 
EL5 C3D  C N N 103 
EL5 C4A  C N N 104 
EL5 C4B  C N N 105 
EL5 C4C  C Y N 106 
EL5 C4D  C N N 107 
EL5 CAA  C N N 108 
EL5 CAB  C N N 109 
EL5 CAC  C N N 110 
EL5 CAD  C N N 111 
EL5 CBA  C N N 112 
EL5 CBB  C N N 113 
EL5 CBC  C N N 114 
EL5 CBD  C N N 115 
EL5 CGB  C N N 116 
EL5 CGC  C N N 117 
EL5 CHB  C N N 118 
EL5 CHC  C N N 119 
EL5 CHD  C N N 120 
EL5 CMA  C N N 121 
EL5 CMB  C N N 122 
EL5 CMC  C N N 123 
EL5 CMD  C N N 124 
EL5 NA   N N N 125 
EL5 OA   O N N 126 
EL5 NB   N N N 127 
EL5 NC   N Y N 128 
EL5 ND   N N N 129 
EL5 OD   O N N 130 
EL5 H1   H N N 131 
EL5 H2   H N N 132 
EL5 H3   H N N 133 
EL5 H4   H N N 134 
EL5 H6   H N N 135 
EL5 H7   H N N 136 
EL5 H8   H N N 137 
EL5 H9   H N N 138 
EL5 H10  H N N 139 
EL5 H12  H N N 140 
EL5 H13  H N N 141 
EL5 H14  H N N 142 
EL5 H15  H N N 143 
EL5 H16  H N N 144 
EL5 H17  H N N 145 
EL5 H18  H N N 146 
EL5 H19  H N N 147 
EL5 H20  H N N 148 
EL5 H22  H N N 149 
EL5 H24  H N N 150 
EL5 H26  H N N 151 
EL5 H28  H N N 152 
EL5 H29  H N N 153 
EL5 H30  H N N 154 
EL5 H31  H N N 155 
EL5 H32  H N N 156 
EL5 H33  H N N 157 
EL5 H34  H N N 158 
EL5 H35  H N N 159 
EL5 H36  H N N 160 
EL5 H37  H N N 161 
EL5 H38  H N N 162 
EL5 H39  H N N 163 
EL5 H40  H N N 164 
EL5 H42  H N N 165 
EL5 H5   H N N 166 
GLN N    N N N 167 
GLN CA   C N S 168 
GLN C    C N N 169 
GLN O    O N N 170 
GLN CB   C N N 171 
GLN CG   C N N 172 
GLN CD   C N N 173 
GLN OE1  O N N 174 
GLN NE2  N N N 175 
GLN OXT  O N N 176 
GLN H    H N N 177 
GLN H2   H N N 178 
GLN HA   H N N 179 
GLN HB2  H N N 180 
GLN HB3  H N N 181 
GLN HG2  H N N 182 
GLN HG3  H N N 183 
GLN HE21 H N N 184 
GLN HE22 H N N 185 
GLN HXT  H N N 186 
GLU N    N N N 187 
GLU CA   C N S 188 
GLU C    C N N 189 
GLU O    O N N 190 
GLU CB   C N N 191 
GLU CG   C N N 192 
GLU CD   C N N 193 
GLU OE1  O N N 194 
GLU OE2  O N N 195 
GLU OXT  O N N 196 
GLU H    H N N 197 
GLU H2   H N N 198 
GLU HA   H N N 199 
GLU HB2  H N N 200 
GLU HB3  H N N 201 
GLU HG2  H N N 202 
GLU HG3  H N N 203 
GLU HE2  H N N 204 
GLU HXT  H N N 205 
GLY N    N N N 206 
GLY CA   C N N 207 
GLY C    C N N 208 
GLY O    O N N 209 
GLY OXT  O N N 210 
GLY H    H N N 211 
GLY H2   H N N 212 
GLY HA2  H N N 213 
GLY HA3  H N N 214 
GLY HXT  H N N 215 
HIS N    N N N 216 
HIS CA   C N S 217 
HIS C    C N N 218 
HIS O    O N N 219 
HIS CB   C N N 220 
HIS CG   C Y N 221 
HIS ND1  N Y N 222 
HIS CD2  C Y N 223 
HIS CE1  C Y N 224 
HIS NE2  N Y N 225 
HIS OXT  O N N 226 
HIS H    H N N 227 
HIS H2   H N N 228 
HIS HA   H N N 229 
HIS HB2  H N N 230 
HIS HB3  H N N 231 
HIS HD1  H N N 232 
HIS HD2  H N N 233 
HIS HE1  H N N 234 
HIS HE2  H N N 235 
HIS HXT  H N N 236 
HOH O    O N N 237 
HOH H1   H N N 238 
HOH H2   H N N 239 
ILE N    N N N 240 
ILE CA   C N S 241 
ILE C    C N N 242 
ILE O    O N N 243 
ILE CB   C N S 244 
ILE CG1  C N N 245 
ILE CG2  C N N 246 
ILE CD1  C N N 247 
ILE OXT  O N N 248 
ILE H    H N N 249 
ILE H2   H N N 250 
ILE HA   H N N 251 
ILE HB   H N N 252 
ILE HG12 H N N 253 
ILE HG13 H N N 254 
ILE HG21 H N N 255 
ILE HG22 H N N 256 
ILE HG23 H N N 257 
ILE HD11 H N N 258 
ILE HD12 H N N 259 
ILE HD13 H N N 260 
ILE HXT  H N N 261 
LEU N    N N N 262 
LEU CA   C N S 263 
LEU C    C N N 264 
LEU O    O N N 265 
LEU CB   C N N 266 
LEU CG   C N N 267 
LEU CD1  C N N 268 
LEU CD2  C N N 269 
LEU OXT  O N N 270 
LEU H    H N N 271 
LEU H2   H N N 272 
LEU HA   H N N 273 
LEU HB2  H N N 274 
LEU HB3  H N N 275 
LEU HG   H N N 276 
LEU HD11 H N N 277 
LEU HD12 H N N 278 
LEU HD13 H N N 279 
LEU HD21 H N N 280 
LEU HD22 H N N 281 
LEU HD23 H N N 282 
LEU HXT  H N N 283 
LYS N    N N N 284 
LYS CA   C N S 285 
LYS C    C N N 286 
LYS O    O N N 287 
LYS CB   C N N 288 
LYS CG   C N N 289 
LYS CD   C N N 290 
LYS CE   C N N 291 
LYS NZ   N N N 292 
LYS OXT  O N N 293 
LYS H    H N N 294 
LYS H2   H N N 295 
LYS HA   H N N 296 
LYS HB2  H N N 297 
LYS HB3  H N N 298 
LYS HG2  H N N 299 
LYS HG3  H N N 300 
LYS HD2  H N N 301 
LYS HD3  H N N 302 
LYS HE2  H N N 303 
LYS HE3  H N N 304 
LYS HZ1  H N N 305 
LYS HZ2  H N N 306 
LYS HZ3  H N N 307 
LYS HXT  H N N 308 
MET N    N N N 309 
MET CA   C N S 310 
MET C    C N N 311 
MET O    O N N 312 
MET CB   C N N 313 
MET CG   C N N 314 
MET SD   S N N 315 
MET CE   C N N 316 
MET OXT  O N N 317 
MET H    H N N 318 
MET H2   H N N 319 
MET HA   H N N 320 
MET HB2  H N N 321 
MET HB3  H N N 322 
MET HG2  H N N 323 
MET HG3  H N N 324 
MET HE1  H N N 325 
MET HE2  H N N 326 
MET HE3  H N N 327 
MET HXT  H N N 328 
PHE N    N N N 329 
PHE CA   C N S 330 
PHE C    C N N 331 
PHE O    O N N 332 
PHE CB   C N N 333 
PHE CG   C Y N 334 
PHE CD1  C Y N 335 
PHE CD2  C Y N 336 
PHE CE1  C Y N 337 
PHE CE2  C Y N 338 
PHE CZ   C Y N 339 
PHE OXT  O N N 340 
PHE H    H N N 341 
PHE H2   H N N 342 
PHE HA   H N N 343 
PHE HB2  H N N 344 
PHE HB3  H N N 345 
PHE HD1  H N N 346 
PHE HD2  H N N 347 
PHE HE1  H N N 348 
PHE HE2  H N N 349 
PHE HZ   H N N 350 
PHE HXT  H N N 351 
PRO N    N N N 352 
PRO CA   C N S 353 
PRO C    C N N 354 
PRO O    O N N 355 
PRO CB   C N N 356 
PRO CG   C N N 357 
PRO CD   C N N 358 
PRO OXT  O N N 359 
PRO H    H N N 360 
PRO HA   H N N 361 
PRO HB2  H N N 362 
PRO HB3  H N N 363 
PRO HG2  H N N 364 
PRO HG3  H N N 365 
PRO HD2  H N N 366 
PRO HD3  H N N 367 
PRO HXT  H N N 368 
SER N    N N N 369 
SER CA   C N S 370 
SER C    C N N 371 
SER O    O N N 372 
SER CB   C N N 373 
SER OG   O N N 374 
SER OXT  O N N 375 
SER H    H N N 376 
SER H2   H N N 377 
SER HA   H N N 378 
SER HB2  H N N 379 
SER HB3  H N N 380 
SER HG   H N N 381 
SER HXT  H N N 382 
THR N    N N N 383 
THR CA   C N S 384 
THR C    C N N 385 
THR O    O N N 386 
THR CB   C N R 387 
THR OG1  O N N 388 
THR CG2  C N N 389 
THR OXT  O N N 390 
THR H    H N N 391 
THR H2   H N N 392 
THR HA   H N N 393 
THR HB   H N N 394 
THR HG1  H N N 395 
THR HG21 H N N 396 
THR HG22 H N N 397 
THR HG23 H N N 398 
THR HXT  H N N 399 
TRP N    N N N 400 
TRP CA   C N S 401 
TRP C    C N N 402 
TRP O    O N N 403 
TRP CB   C N N 404 
TRP CG   C Y N 405 
TRP CD1  C Y N 406 
TRP CD2  C Y N 407 
TRP NE1  N Y N 408 
TRP CE2  C Y N 409 
TRP CE3  C Y N 410 
TRP CZ2  C Y N 411 
TRP CZ3  C Y N 412 
TRP CH2  C Y N 413 
TRP OXT  O N N 414 
TRP H    H N N 415 
TRP H2   H N N 416 
TRP HA   H N N 417 
TRP HB2  H N N 418 
TRP HB3  H N N 419 
TRP HD1  H N N 420 
TRP HE1  H N N 421 
TRP HE3  H N N 422 
TRP HZ2  H N N 423 
TRP HZ3  H N N 424 
TRP HH2  H N N 425 
TRP HXT  H N N 426 
TYR N    N N N 427 
TYR CA   C N S 428 
TYR C    C N N 429 
TYR O    O N N 430 
TYR CB   C N N 431 
TYR CG   C Y N 432 
TYR CD1  C Y N 433 
TYR CD2  C Y N 434 
TYR CE1  C Y N 435 
TYR CE2  C Y N 436 
TYR CZ   C Y N 437 
TYR OH   O N N 438 
TYR OXT  O N N 439 
TYR H    H N N 440 
TYR H2   H N N 441 
TYR HA   H N N 442 
TYR HB2  H N N 443 
TYR HB3  H N N 444 
TYR HD1  H N N 445 
TYR HD2  H N N 446 
TYR HE1  H N N 447 
TYR HE2  H N N 448 
TYR HH   H N N 449 
TYR HXT  H N N 450 
VAL N    N N N 451 
VAL CA   C N S 452 
VAL C    C N N 453 
VAL O    O N N 454 
VAL CB   C N N 455 
VAL CG1  C N N 456 
VAL CG2  C N N 457 
VAL OXT  O N N 458 
VAL H    H N N 459 
VAL H2   H N N 460 
VAL HA   H N N 461 
VAL HB   H N N 462 
VAL HG11 H N N 463 
VAL HG12 H N N 464 
VAL HG13 H N N 465 
VAL HG21 H N N 466 
VAL HG22 H N N 467 
VAL HG23 H N N 468 
VAL HXT  H N N 469 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EL5 OD  C4D  doub N N 83  
EL5 ND  C4D  sing N N 84  
EL5 ND  C1D  sing N N 85  
EL5 CMA C2A  sing N N 86  
EL5 CBA CAA  sing N N 87  
EL5 C4D C3D  sing N N 88  
EL5 C2A C1A  sing N N 89  
EL5 C2A C3A  sing N N 90  
EL5 OA  C1A  doub N N 91  
EL5 CBD CAD  doub N N 92  
EL5 CAA C3A  doub N E 93  
EL5 C1A NA   sing N N 94  
EL5 CHD C1D  doub N E 95  
EL5 CHD C4C  sing N N 96  
EL5 C3A C4A  sing N N 97  
EL5 C1D C2D  sing N N 98  
EL5 C3D CAD  sing N N 99  
EL5 C3D C2D  doub N N 100 
EL5 CMC C3C  sing N N 101 
EL5 NA  C4A  sing N N 102 
EL5 C4A CHB  doub N Z 103 
EL5 C4C C3C  doub Y N 104 
EL5 C4C NC   sing Y N 105 
EL5 C2D CMD  sing N N 106 
EL5 C3C C2C  sing Y N 107 
EL5 NC  C1C  sing Y N 108 
EL5 CHB C1B  sing N N 109 
EL5 C2C C1C  doub Y N 110 
EL5 C2C CAC  sing N N 111 
EL5 NB  C1B  doub N N 112 
EL5 NB  C4B  sing N N 113 
EL5 C1C CHC  sing N N 114 
EL5 C1B C2B  sing N N 115 
EL5 CAC CBC  sing N N 116 
EL5 C4B CHC  doub N Z 117 
EL5 C4B C3B  sing N N 118 
EL5 C2B C3B  doub N N 119 
EL5 C2B CMB  sing N N 120 
EL5 O1C CGC  doub N N 121 
EL5 C3B CAB  sing N N 122 
EL5 CBC CGC  sing N N 123 
EL5 CGC O2C  sing N N 124 
EL5 CAB CBB  sing N N 125 
EL5 CBB CGB  sing N N 126 
EL5 CGB O2B  doub N N 127 
EL5 CGB O1B  sing N N 128 
EL5 O1B H1   sing N N 129 
EL5 C2A H2   sing N N 130 
EL5 O2C H3   sing N N 131 
EL5 CAA H4   sing N N 132 
EL5 CAB H6   sing N N 133 
EL5 CAB H7   sing N N 134 
EL5 CAC H8   sing N N 135 
EL5 CAC H9   sing N N 136 
EL5 CAD H10  sing N N 137 
EL5 CBA H12  sing N N 138 
EL5 CBA H13  sing N N 139 
EL5 CBA H14  sing N N 140 
EL5 CBB H15  sing N N 141 
EL5 CBB H16  sing N N 142 
EL5 CBC H17  sing N N 143 
EL5 CBC H18  sing N N 144 
EL5 CBD H19  sing N N 145 
EL5 CBD H20  sing N N 146 
EL5 CHB H22  sing N N 147 
EL5 CHC H24  sing N N 148 
EL5 CHD H26  sing N N 149 
EL5 CMA H28  sing N N 150 
EL5 CMA H29  sing N N 151 
EL5 CMA H30  sing N N 152 
EL5 CMB H31  sing N N 153 
EL5 CMB H32  sing N N 154 
EL5 CMB H33  sing N N 155 
EL5 CMC H34  sing N N 156 
EL5 CMC H35  sing N N 157 
EL5 CMC H36  sing N N 158 
EL5 CMD H37  sing N N 159 
EL5 CMD H38  sing N N 160 
EL5 CMD H39  sing N N 161 
EL5 NA  H40  sing N N 162 
EL5 NC  H42  sing N N 163 
EL5 ND  H5   sing N N 164 
GLN N   CA   sing N N 165 
GLN N   H    sing N N 166 
GLN N   H2   sing N N 167 
GLN CA  C    sing N N 168 
GLN CA  CB   sing N N 169 
GLN CA  HA   sing N N 170 
GLN C   O    doub N N 171 
GLN C   OXT  sing N N 172 
GLN CB  CG   sing N N 173 
GLN CB  HB2  sing N N 174 
GLN CB  HB3  sing N N 175 
GLN CG  CD   sing N N 176 
GLN CG  HG2  sing N N 177 
GLN CG  HG3  sing N N 178 
GLN CD  OE1  doub N N 179 
GLN CD  NE2  sing N N 180 
GLN NE2 HE21 sing N N 181 
GLN NE2 HE22 sing N N 182 
GLN OXT HXT  sing N N 183 
GLU N   CA   sing N N 184 
GLU N   H    sing N N 185 
GLU N   H2   sing N N 186 
GLU CA  C    sing N N 187 
GLU CA  CB   sing N N 188 
GLU CA  HA   sing N N 189 
GLU C   O    doub N N 190 
GLU C   OXT  sing N N 191 
GLU CB  CG   sing N N 192 
GLU CB  HB2  sing N N 193 
GLU CB  HB3  sing N N 194 
GLU CG  CD   sing N N 195 
GLU CG  HG2  sing N N 196 
GLU CG  HG3  sing N N 197 
GLU CD  OE1  doub N N 198 
GLU CD  OE2  sing N N 199 
GLU OE2 HE2  sing N N 200 
GLU OXT HXT  sing N N 201 
GLY N   CA   sing N N 202 
GLY N   H    sing N N 203 
GLY N   H2   sing N N 204 
GLY CA  C    sing N N 205 
GLY CA  HA2  sing N N 206 
GLY CA  HA3  sing N N 207 
GLY C   O    doub N N 208 
GLY C   OXT  sing N N 209 
GLY OXT HXT  sing N N 210 
HIS N   CA   sing N N 211 
HIS N   H    sing N N 212 
HIS N   H2   sing N N 213 
HIS CA  C    sing N N 214 
HIS CA  CB   sing N N 215 
HIS CA  HA   sing N N 216 
HIS C   O    doub N N 217 
HIS C   OXT  sing N N 218 
HIS CB  CG   sing N N 219 
HIS CB  HB2  sing N N 220 
HIS CB  HB3  sing N N 221 
HIS CG  ND1  sing Y N 222 
HIS CG  CD2  doub Y N 223 
HIS ND1 CE1  doub Y N 224 
HIS ND1 HD1  sing N N 225 
HIS CD2 NE2  sing Y N 226 
HIS CD2 HD2  sing N N 227 
HIS CE1 NE2  sing Y N 228 
HIS CE1 HE1  sing N N 229 
HIS NE2 HE2  sing N N 230 
HIS OXT HXT  sing N N 231 
HOH O   H1   sing N N 232 
HOH O   H2   sing N N 233 
ILE N   CA   sing N N 234 
ILE N   H    sing N N 235 
ILE N   H2   sing N N 236 
ILE CA  C    sing N N 237 
ILE CA  CB   sing N N 238 
ILE CA  HA   sing N N 239 
ILE C   O    doub N N 240 
ILE C   OXT  sing N N 241 
ILE CB  CG1  sing N N 242 
ILE CB  CG2  sing N N 243 
ILE CB  HB   sing N N 244 
ILE CG1 CD1  sing N N 245 
ILE CG1 HG12 sing N N 246 
ILE CG1 HG13 sing N N 247 
ILE CG2 HG21 sing N N 248 
ILE CG2 HG22 sing N N 249 
ILE CG2 HG23 sing N N 250 
ILE CD1 HD11 sing N N 251 
ILE CD1 HD12 sing N N 252 
ILE CD1 HD13 sing N N 253 
ILE OXT HXT  sing N N 254 
LEU N   CA   sing N N 255 
LEU N   H    sing N N 256 
LEU N   H2   sing N N 257 
LEU CA  C    sing N N 258 
LEU CA  CB   sing N N 259 
LEU CA  HA   sing N N 260 
LEU C   O    doub N N 261 
LEU C   OXT  sing N N 262 
LEU CB  CG   sing N N 263 
LEU CB  HB2  sing N N 264 
LEU CB  HB3  sing N N 265 
LEU CG  CD1  sing N N 266 
LEU CG  CD2  sing N N 267 
LEU CG  HG   sing N N 268 
LEU CD1 HD11 sing N N 269 
LEU CD1 HD12 sing N N 270 
LEU CD1 HD13 sing N N 271 
LEU CD2 HD21 sing N N 272 
LEU CD2 HD22 sing N N 273 
LEU CD2 HD23 sing N N 274 
LEU OXT HXT  sing N N 275 
LYS N   CA   sing N N 276 
LYS N   H    sing N N 277 
LYS N   H2   sing N N 278 
LYS CA  C    sing N N 279 
LYS CA  CB   sing N N 280 
LYS CA  HA   sing N N 281 
LYS C   O    doub N N 282 
LYS C   OXT  sing N N 283 
LYS CB  CG   sing N N 284 
LYS CB  HB2  sing N N 285 
LYS CB  HB3  sing N N 286 
LYS CG  CD   sing N N 287 
LYS CG  HG2  sing N N 288 
LYS CG  HG3  sing N N 289 
LYS CD  CE   sing N N 290 
LYS CD  HD2  sing N N 291 
LYS CD  HD3  sing N N 292 
LYS CE  NZ   sing N N 293 
LYS CE  HE2  sing N N 294 
LYS CE  HE3  sing N N 295 
LYS NZ  HZ1  sing N N 296 
LYS NZ  HZ2  sing N N 297 
LYS NZ  HZ3  sing N N 298 
LYS OXT HXT  sing N N 299 
MET N   CA   sing N N 300 
MET N   H    sing N N 301 
MET N   H2   sing N N 302 
MET CA  C    sing N N 303 
MET CA  CB   sing N N 304 
MET CA  HA   sing N N 305 
MET C   O    doub N N 306 
MET C   OXT  sing N N 307 
MET CB  CG   sing N N 308 
MET CB  HB2  sing N N 309 
MET CB  HB3  sing N N 310 
MET CG  SD   sing N N 311 
MET CG  HG2  sing N N 312 
MET CG  HG3  sing N N 313 
MET SD  CE   sing N N 314 
MET CE  HE1  sing N N 315 
MET CE  HE2  sing N N 316 
MET CE  HE3  sing N N 317 
MET OXT HXT  sing N N 318 
PHE N   CA   sing N N 319 
PHE N   H    sing N N 320 
PHE N   H2   sing N N 321 
PHE CA  C    sing N N 322 
PHE CA  CB   sing N N 323 
PHE CA  HA   sing N N 324 
PHE C   O    doub N N 325 
PHE C   OXT  sing N N 326 
PHE CB  CG   sing N N 327 
PHE CB  HB2  sing N N 328 
PHE CB  HB3  sing N N 329 
PHE CG  CD1  doub Y N 330 
PHE CG  CD2  sing Y N 331 
PHE CD1 CE1  sing Y N 332 
PHE CD1 HD1  sing N N 333 
PHE CD2 CE2  doub Y N 334 
PHE CD2 HD2  sing N N 335 
PHE CE1 CZ   doub Y N 336 
PHE CE1 HE1  sing N N 337 
PHE CE2 CZ   sing Y N 338 
PHE CE2 HE2  sing N N 339 
PHE CZ  HZ   sing N N 340 
PHE OXT HXT  sing N N 341 
PRO N   CA   sing N N 342 
PRO N   CD   sing N N 343 
PRO N   H    sing N N 344 
PRO CA  C    sing N N 345 
PRO CA  CB   sing N N 346 
PRO CA  HA   sing N N 347 
PRO C   O    doub N N 348 
PRO C   OXT  sing N N 349 
PRO CB  CG   sing N N 350 
PRO CB  HB2  sing N N 351 
PRO CB  HB3  sing N N 352 
PRO CG  CD   sing N N 353 
PRO CG  HG2  sing N N 354 
PRO CG  HG3  sing N N 355 
PRO CD  HD2  sing N N 356 
PRO CD  HD3  sing N N 357 
PRO OXT HXT  sing N N 358 
SER N   CA   sing N N 359 
SER N   H    sing N N 360 
SER N   H2   sing N N 361 
SER CA  C    sing N N 362 
SER CA  CB   sing N N 363 
SER CA  HA   sing N N 364 
SER C   O    doub N N 365 
SER C   OXT  sing N N 366 
SER CB  OG   sing N N 367 
SER CB  HB2  sing N N 368 
SER CB  HB3  sing N N 369 
SER OG  HG   sing N N 370 
SER OXT HXT  sing N N 371 
THR N   CA   sing N N 372 
THR N   H    sing N N 373 
THR N   H2   sing N N 374 
THR CA  C    sing N N 375 
THR CA  CB   sing N N 376 
THR CA  HA   sing N N 377 
THR C   O    doub N N 378 
THR C   OXT  sing N N 379 
THR CB  OG1  sing N N 380 
THR CB  CG2  sing N N 381 
THR CB  HB   sing N N 382 
THR OG1 HG1  sing N N 383 
THR CG2 HG21 sing N N 384 
THR CG2 HG22 sing N N 385 
THR CG2 HG23 sing N N 386 
THR OXT HXT  sing N N 387 
TRP N   CA   sing N N 388 
TRP N   H    sing N N 389 
TRP N   H2   sing N N 390 
TRP CA  C    sing N N 391 
TRP CA  CB   sing N N 392 
TRP CA  HA   sing N N 393 
TRP C   O    doub N N 394 
TRP C   OXT  sing N N 395 
TRP CB  CG   sing N N 396 
TRP CB  HB2  sing N N 397 
TRP CB  HB3  sing N N 398 
TRP CG  CD1  doub Y N 399 
TRP CG  CD2  sing Y N 400 
TRP CD1 NE1  sing Y N 401 
TRP CD1 HD1  sing N N 402 
TRP CD2 CE2  doub Y N 403 
TRP CD2 CE3  sing Y N 404 
TRP NE1 CE2  sing Y N 405 
TRP NE1 HE1  sing N N 406 
TRP CE2 CZ2  sing Y N 407 
TRP CE3 CZ3  doub Y N 408 
TRP CE3 HE3  sing N N 409 
TRP CZ2 CH2  doub Y N 410 
TRP CZ2 HZ2  sing N N 411 
TRP CZ3 CH2  sing Y N 412 
TRP CZ3 HZ3  sing N N 413 
TRP CH2 HH2  sing N N 414 
TRP OXT HXT  sing N N 415 
TYR N   CA   sing N N 416 
TYR N   H    sing N N 417 
TYR N   H2   sing N N 418 
TYR CA  C    sing N N 419 
TYR CA  CB   sing N N 420 
TYR CA  HA   sing N N 421 
TYR C   O    doub N N 422 
TYR C   OXT  sing N N 423 
TYR CB  CG   sing N N 424 
TYR CB  HB2  sing N N 425 
TYR CB  HB3  sing N N 426 
TYR CG  CD1  doub Y N 427 
TYR CG  CD2  sing Y N 428 
TYR CD1 CE1  sing Y N 429 
TYR CD1 HD1  sing N N 430 
TYR CD2 CE2  doub Y N 431 
TYR CD2 HD2  sing N N 432 
TYR CE1 CZ   doub Y N 433 
TYR CE1 HE1  sing N N 434 
TYR CE2 CZ   sing Y N 435 
TYR CE2 HE2  sing N N 436 
TYR CZ  OH   sing N N 437 
TYR OH  HH   sing N N 438 
TYR OXT HXT  sing N N 439 
VAL N   CA   sing N N 440 
VAL N   H    sing N N 441 
VAL N   H2   sing N N 442 
VAL CA  C    sing N N 443 
VAL CA  CB   sing N N 444 
VAL CA  HA   sing N N 445 
VAL C   O    doub N N 446 
VAL C   OXT  sing N N 447 
VAL CB  CG1  sing N N 448 
VAL CB  CG2  sing N N 449 
VAL CB  HB   sing N N 450 
VAL CG1 HG11 sing N N 451 
VAL CG1 HG12 sing N N 452 
VAL CG1 HG13 sing N N 453 
VAL CG2 HG21 sing N N 454 
VAL CG2 HG22 sing N N 455 
VAL CG2 HG23 sing N N 456 
VAL OXT HXT  sing N N 457 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Science Foundation (NSF, United States)' 'United States' 1231306 1 
'National Science Foundation (NSF, United States)' 'United States' 2423601 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6PTX 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9NAA 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016458 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009887 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009667 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 1   ? 8.70719   -8.65511  4.92796  1.000 111.59664 ? 9   ASP A N   1 
ATOM   2    C CA  . ASP A 1 1   ? 9.09077   -8.74895  6.33429  1.000 111.95900 ? 9   ASP A CA  1 
ATOM   3    C C   . ASP A 1 1   ? 10.09521  -9.87778  6.59813  1.000 118.11068 ? 9   ASP A C   1 
ATOM   4    O O   . ASP A 1 1   ? 10.69557  -10.42906 5.66995  1.000 121.28720 ? 9   ASP A O   1 
ATOM   5    C CB  . ASP A 1 1   ? 7.84349   -8.94626  7.20865  1.000 110.64534 ? 9   ASP A CB  1 
ATOM   6    C CG  . ASP A 1 1   ? 7.05491   -7.65861  7.41357  1.000 103.92031 ? 9   ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 1   ? 5.82176   -7.65893  7.18655  1.000 96.15518  ? 9   ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 1   ? 7.68577   -6.63462  7.75558  1.000 98.49061  ? 9   ASP A OD2 1 
ATOM   9    N N   . LEU A 1 2   ? 10.25825  -10.22080 7.87656  1.000 116.55054 ? 10  LEU A N   1 
ATOM   10   C CA  . LEU A 1 2   ? 11.15851  -11.28141 8.32443  1.000 116.20310 ? 10  LEU A CA  1 
ATOM   11   C C   . LEU A 1 2   ? 10.49673  -12.09929 9.42509  1.000 112.17288 ? 10  LEU A C   1 
ATOM   12   O O   . LEU A 1 2   ? 11.11963  -12.40751 10.44682 1.000 109.14221 ? 10  LEU A O   1 
ATOM   13   C CB  . LEU A 1 2   ? 12.50985  -10.73740 8.79452  1.000 112.99582 ? 10  LEU A CB  1 
ATOM   14   C CG  . LEU A 1 2   ? 13.35891  -9.93497  7.80363  1.000 114.49032 ? 10  LEU A CG  1 
ATOM   15   C CD1 . LEU A 1 2   ? 14.45968  -9.18209  8.53200  1.000 109.57656 ? 10  LEU A CD1 1 
ATOM   16   C CD2 . LEU A 1 2   ? 13.93530  -10.82482 6.70643  1.000 118.62780 ? 10  LEU A CD2 1 
ATOM   17   N N   . SER A 1 3   ? 9.19913   -12.39741 9.24935  1.000 113.43097 ? 11  SER A N   1 
ATOM   18   C CA  . SER A 1 3   ? 8.37628   -13.30617 10.05857 1.000 109.77574 ? 11  SER A CA  1 
ATOM   19   C C   . SER A 1 3   ? 9.13197   -14.22785 11.02199 1.000 105.47592 ? 11  SER A C   1 
ATOM   20   O O   . SER A 1 3   ? 8.60515   -14.57001 12.08935 1.000 97.98887  ? 11  SER A O   1 
ATOM   21   C CB  . SER A 1 3   ? 7.49416   -14.14787 9.12420  1.000 115.78589 ? 11  SER A CB  1 
ATOM   22   O OG  . SER A 1 3   ? 8.27163   -14.98858 8.28590  1.000 118.90903 ? 11  SER A OG  1 
ATOM   23   N N   . GLN A 1 4   ? 10.35914  -14.63465 10.66459 1.000 109.33573 ? 12  GLN A N   1 
ATOM   24   C CA  . GLN A 1 4   ? 11.18075  -15.42996 11.57165 1.000 107.32545 ? 12  GLN A CA  1 
ATOM   25   C C   . GLN A 1 4   ? 11.48923  -14.66337 12.85323 1.000 100.60320 ? 12  GLN A C   1 
ATOM   26   O O   . GLN A 1 4   ? 11.75476  -15.28261 13.88856 1.000 102.12125 ? 12  GLN A O   1 
ATOM   27   C CB  . GLN A 1 4   ? 12.48956  -15.83395 10.87984 1.000 111.35099 ? 12  GLN A CB  1 
ATOM   28   C CG  . GLN A 1 4   ? 12.33938  -16.82131 9.71993  1.000 115.26004 ? 12  GLN A CG  1 
ATOM   29   C CD  . GLN A 1 4   ? 11.93048  -18.21466 10.16513 1.000 116.15385 ? 12  GLN A CD  1 
ATOM   30   O OE1 . GLN A 1 4   ? 12.57511  -18.82275 11.01793 1.000 117.48253 ? 12  GLN A OE1 1 
ATOM   31   N NE2 . GLN A 1 4   ? 10.86354  -18.73348 9.57328  1.000 117.18931 ? 12  GLN A NE2 1 
ATOM   32   N N   . CYS A 1 5   ? 11.44837  -13.32644 12.80273 1.000 96.97374  ? 13  CYS A N   1 
ATOM   33   C CA  . CYS A 1 5   ? 11.63887  -12.48073 13.97399 1.000 85.85082  ? 13  CYS A CA  1 
ATOM   34   C C   . CYS A 1 5   ? 10.49484  -11.50462 14.21251 1.000 80.50268  ? 13  CYS A C   1 
ATOM   35   O O   . CYS A 1 5   ? 10.50666  -10.82230 15.24241 1.000 71.34809  ? 13  CYS A O   1 
ATOM   36   C CB  . CYS A 1 5   ? 12.93898  -11.66536 13.86377 1.000 83.29632  ? 13  CYS A CB  1 
ATOM   37   S SG  . CYS A 1 5   ? 12.98087  -10.52082 12.44663 1.000 84.83968  ? 13  CYS A SG  1 
ATOM   38   N N   . ASP A 1 6   ? 9.51534   -11.40604 13.30856 1.000 81.71814  ? 14  ASP A N   1 
ATOM   39   C CA  . ASP A 1 6   ? 8.37675   -10.52586 13.55133 1.000 77.48037  ? 14  ASP A CA  1 
ATOM   40   C C   . ASP A 1 6   ? 7.31161   -11.18839 14.41434 1.000 71.34067  ? 14  ASP A C   1 
ATOM   41   O O   . ASP A 1 6   ? 6.26410   -10.57995 14.67050 1.000 63.07233  ? 14  ASP A O   1 
ATOM   42   C CB  . ASP A 1 6   ? 7.76588   -10.06206 12.22010 1.000 83.26455  ? 14  ASP A CB  1 
ATOM   43   C CG  . ASP A 1 6   ? 8.59493   -8.96596  11.52696 1.000 90.74759  ? 14  ASP A CG  1 
ATOM   44   O OD1 . ASP A 1 6   ? 9.07690   -8.02050  12.20585 1.000 78.86371  ? 14  ASP A OD1 1 
ATOM   45   O OD2 . ASP A 1 6   ? 8.77295   -9.05703  10.29077 1.000 102.97241 ? 14  ASP A OD2 1 
ATOM   46   N N   . ARG A 1 7   ? 7.55524   -12.42476 14.84808 1.000 68.60102  ? 15  ARG A N   1 
ATOM   47   C CA  . ARG A 1 7   ? 6.82287   -13.05168 15.93983 1.000 65.44254  ? 15  ARG A CA  1 
ATOM   48   C C   . ARG A 1 7   ? 7.67672   -13.19508 17.19497 1.000 59.26793  ? 15  ARG A C   1 
ATOM   49   O O   . ARG A 1 7   ? 7.38926   -14.04765 18.03695 1.000 60.23064  ? 15  ARG A O   1 
ATOM   50   C CB  . ARG A 1 7   ? 6.21427   -14.39245 15.51416 1.000 63.52318  ? 15  ARG A CB  1 
ATOM   51   C CG  . ARG A 1 7   ? 5.45642   -14.32048 14.20209 1.000 61.11052  ? 15  ARG A CG  1 
ATOM   52   C CD  . ARG A 1 7   ? 4.27853   -13.40524 14.43171 1.000 58.27664  ? 15  ARG A CD  1 
ATOM   53   N NE  . ARG A 1 7   ? 3.26468   -13.39986 13.38266 1.000 58.35649  ? 15  ARG A NE  1 
ATOM   54   C CZ  . ARG A 1 7   ? 2.11683   -14.07328 13.43173 1.000 60.49982  ? 15  ARG A CZ  1 
ATOM   55   N NH1 . ARG A 1 7   ? 1.84864   -14.92892 14.41564 1.000 56.01601  ? 15  ARG A NH1 1 
ATOM   56   N NH2 . ARG A 1 7   ? 1.20543   -13.87066 12.47881 1.000 50.40045  ? 15  ARG A NH2 1 
ATOM   57   N N   . GLU A 1 8   ? 8.75561   -12.42483 17.30484 1.000 63.06478  ? 16  GLU A N   1 
ATOM   58   C CA  . GLU A 1 8   ? 9.66920   -12.53537 18.44537 1.000 53.50715  ? 16  GLU A CA  1 
ATOM   59   C C   . GLU A 1 8   ? 8.99041   -12.06261 19.73036 1.000 49.18672  ? 16  GLU A C   1 
ATOM   60   O O   . GLU A 1 8   ? 8.49220   -10.92822 19.77886 1.000 48.16392  ? 16  GLU A O   1 
ATOM   61   C CB  . GLU A 1 8   ? 10.92339  -11.71108 18.18637 1.000 48.76438  ? 16  GLU A CB  1 
ATOM   62   C CG  . GLU A 1 8   ? 12.07729  -12.01492 19.12437 1.000 50.03127  ? 16  GLU A CG  1 
ATOM   63   C CD  . GLU A 1 8   ? 13.30156  -11.08645 18.91182 1.000 53.36100  ? 16  GLU A CD  1 
ATOM   64   O OE1 . GLU A 1 8   ? 14.23245  -11.14841 19.74503 1.000 53.58876  ? 16  GLU A OE1 1 
ATOM   65   O OE2 . GLU A 1 8   ? 13.37459  -10.35602 17.88390 1.000 52.61294  ? 16  GLU A OE2 1 
ATOM   66   N N   . PRO A 1 9   ? 8.92177   -12.88858 20.77659 1.000 46.67364  ? 17  PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? 8.39287   -12.41411 22.06362 1.000 45.22713  ? 17  PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? 9.42366   -11.59105 22.83420 1.000 41.11682  ? 17  PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? 10.01936  -12.01937 23.82792 1.000 41.93506  ? 17  PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? 8.04734   -13.71658 22.78485 1.000 40.89502  ? 17  PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? 9.03556   -14.69225 22.27396 1.000 41.61813  ? 17  PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? 9.33185   -14.30160 20.84226 1.000 47.70189  ? 17  PRO A CD  1 
ATOM   73   N N   . ILE A 1 10  ? 9.62122   -10.35250 22.38386 1.000 37.56706  ? 18  ILE A N   1 
ATOM   74   C CA  . ILE A 1 10  ? 10.65282  -9.49519  22.94661 1.000 41.96738  ? 18  ILE A CA  1 
ATOM   75   C C   . ILE A 1 10  ? 10.40076  -9.15979  24.40746 1.000 40.69363  ? 18  ILE A C   1 
ATOM   76   O O   . ILE A 1 10  ? 11.29426  -8.63949  25.07858 1.000 38.14211  ? 18  ILE A O   1 
ATOM   77   C CB  . ILE A 1 10  ? 10.76166  -8.19683  22.13376 1.000 39.30196  ? 18  ILE A CB  1 
ATOM   78   C CG1 . ILE A 1 10  ? 9.39009   -7.49731  22.16183 1.000 40.54102  ? 18  ILE A CG1 1 
ATOM   79   C CG2 . ILE A 1 10  ? 11.20322  -8.51484  20.70974 1.000 39.66991  ? 18  ILE A CG2 1 
ATOM   80   C CD1 . ILE A 1 10  ? 9.41087   -6.08188  21.64196 1.000 39.39191  ? 18  ILE A CD1 1 
ATOM   81   N N   . HIS A 1 11  ? 9.22053   -9.46579  24.92848 1.000 36.68054  ? 19  HIS A N   1 
ATOM   82   C CA  . HIS A 1 11  ? 8.96479   -9.28587  26.35182 1.000 39.24827  ? 19  HIS A CA  1 
ATOM   83   C C   . HIS A 1 11  ? 9.35544   -10.51384 27.17296 1.000 36.97220  ? 19  HIS A C   1 
ATOM   84   O O   . HIS A 1 11  ? 9.21505   -10.49617 28.40146 1.000 36.38726  ? 19  HIS A O   1 
ATOM   85   C CB  . HIS A 1 11  ? 7.48030   -8.95991  26.59387 1.000 41.05834  ? 19  HIS A CB  1 
ATOM   86   C CG  . HIS A 1 11  ? 6.54321   -10.01388 26.09085 1.000 37.85670  ? 19  HIS A CG  1 
ATOM   87   N ND1 . HIS A 1 11  ? 6.55255   -10.45966 24.78782 1.000 38.86380  ? 19  HIS A ND1 1 
ATOM   88   C CD2 . HIS A 1 11  ? 5.58291   -10.72508 26.72544 1.000 41.95564  ? 19  HIS A CD2 1 
ATOM   89   C CE1 . HIS A 1 11  ? 5.63009   -11.39582 24.63976 1.000 44.43612  ? 19  HIS A CE1 1 
ATOM   90   N NE2 . HIS A 1 11  ? 5.02384   -11.57265 25.79956 1.000 42.00926  ? 19  HIS A NE2 1 
ATOM   91   N N   . LEU A 1 12  ? 9.81713   -11.58373 26.52227 1.000 38.26324  ? 20  LEU A N   1 
ATOM   92   C CA  . LEU A 1 12  ? 10.04999  -12.85840 27.19572 1.000 41.27928  ? 20  LEU A CA  1 
ATOM   93   C C   . LEU A 1 12  ? 11.45662  -13.38226 26.94792 1.000 41.04325  ? 20  LEU A C   1 
ATOM   94   O O   . LEU A 1 12  ? 11.68024  -14.58646 27.03887 1.000 40.46545  ? 20  LEU A O   1 
ATOM   95   C CB  . LEU A 1 12  ? 9.01077   -13.90587 26.76518 1.000 39.55250  ? 20  LEU A CB  1 
ATOM   96   C CG  . LEU A 1 12  ? 7.52280   -13.59972 27.03278 1.000 43.46931  ? 20  LEU A CG  1 
ATOM   97   C CD1 . LEU A 1 12  ? 6.59988   -14.69978 26.48260 1.000 43.53399  ? 20  LEU A CD1 1 
ATOM   98   C CD2 . LEU A 1 12  ? 7.25733   -13.40206 28.52703 1.000 39.61143  ? 20  LEU A CD2 1 
ATOM   99   N N   . LEU A 1 13  ? 12.40688  -12.50108 26.63639 1.000 39.69290  ? 21  LEU A N   1 
ATOM   100  C CA  . LEU A 1 13  ? 13.74584  -12.93770 26.29488 1.000 39.23576  ? 21  LEU A CA  1 
ATOM   101  C C   . LEU A 1 13  ? 14.53862  -13.36076 27.52560 1.000 45.04156  ? 21  LEU A C   1 
ATOM   102  O O   . LEU A 1 13  ? 15.58337  -14.00808 27.39033 1.000 43.61748  ? 21  LEU A O   1 
ATOM   103  C CB  . LEU A 1 13  ? 14.47335  -11.82658 25.53951 1.000 39.37177  ? 21  LEU A CB  1 
ATOM   104  C CG  . LEU A 1 13  ? 13.75337  -11.37703 24.26746 1.000 40.42054  ? 21  LEU A CG  1 
ATOM   105  C CD1 . LEU A 1 13  ? 14.54750  -10.31539 23.53290 1.000 39.84253  ? 21  LEU A CD1 1 
ATOM   106  C CD2 . LEU A 1 13  ? 13.49419  -12.55597 23.36818 1.000 39.04734  ? 21  LEU A CD2 1 
ATOM   107  N N   . GLY A 1 14  ? 14.09135  -12.98633 28.71897 1.000 43.02213  ? 22  GLY A N   1 
ATOM   108  C CA  . GLY A 1 14  ? 14.75874  -13.48688 29.90145 1.000 43.28832  ? 22  GLY A CA  1 
ATOM   109  C C   . GLY A 1 14  ? 16.11331  -12.88022 30.16821 1.000 41.01713  ? 22  GLY A C   1 
ATOM   110  O O   . GLY A 1 14  ? 16.94577  -13.52299 30.80834 1.000 45.01305  ? 22  GLY A O   1 
ATOM   111  N N   . GLY A 1 15  ? 16.36382  -11.65469 29.69633 1.000 46.40652  ? 23  GLY A N   1 
ATOM   112  C CA  . GLY A 1 15  ? 17.64550  -11.00776 29.91332 1.000 38.10843  ? 23  GLY A CA  1 
ATOM   113  C C   . GLY A 1 15  ? 17.47377  -9.53752  30.25150 1.000 40.72790  ? 23  GLY A C   1 
ATOM   114  O O   . GLY A 1 15  ? 16.41552  -8.94354  30.03554 1.000 39.20919  ? 23  GLY A O   1 
ATOM   115  N N   . ILE A 1 16  ? 18.53128  -8.95628  30.81428 1.000 37.61940  ? 24  ILE A N   1 
ATOM   116  C CA  . ILE A 1 16  ? 18.59601  -7.51636  31.03653 1.000 36.17517  ? 24  ILE A CA  1 
ATOM   117  C C   . ILE A 1 16  ? 19.88809  -6.99487  30.44306 1.000 36.18770  ? 24  ILE A C   1 
ATOM   118  O O   . ILE A 1 16  ? 20.78800  -7.75853  30.08303 1.000 39.56910  ? 24  ILE A O   1 
ATOM   119  C CB  . ILE A 1 16  ? 18.50802  -7.11281  32.52287 1.000 36.40520  ? 24  ILE A CB  1 
ATOM   120  C CG1 . ILE A 1 16  ? 19.64010  -7.75788  33.33354 1.000 32.93132  ? 24  ILE A CG1 1 
ATOM   121  C CG2 . ILE A 1 16  ? 17.13593  -7.42721  33.09288 1.000 34.90786  ? 24  ILE A CG2 1 
ATOM   122  C CD1 . ILE A 1 16  ? 19.73501  -7.24349  34.74423 1.000 33.15855  ? 24  ILE A CD1 1 
ATOM   123  N N   . GLN A 1 17  ? 19.96352  -5.67071  30.34587 1.000 38.66105  ? 25  GLN A N   1 
ATOM   124  C CA  . GLN A 1 17  ? 21.20535  -4.99683  29.98471 1.000 36.52809  ? 25  GLN A CA  1 
ATOM   125  C C   . GLN A 1 17  ? 22.16467  -5.01415  31.16811 1.000 33.44953  ? 25  GLN A C   1 
ATOM   126  O O   . GLN A 1 17  ? 21.75472  -4.96335  32.32735 1.000 35.21573  ? 25  GLN A O   1 
ATOM   127  C CB  . GLN A 1 17  ? 20.91473  -3.56358  29.54065 1.000 37.12443  ? 25  GLN A CB  1 
ATOM   128  C CG  . GLN A 1 17  ? 20.00420  -3.49312  28.32043 1.000 37.20144  ? 25  GLN A CG  1 
ATOM   129  C CD  . GLN A 1 17  ? 19.56656  -2.06801  28.01445 1.000 41.22967  ? 25  GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 17  ? 20.40087  -1.15841  27.98289 1.000 36.02831  ? 25  GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 17  ? 18.24477  -1.86105  27.82043 1.000 35.06816  ? 25  GLN A NE2 1 
ATOM   132  N N   . SER A 1 18  ? 23.46111  -5.07636  30.86730 1.000 36.95424  ? 26  SER A N   1 
ATOM   133  C CA  . SER A 1 18  ? 24.46275  -5.40901  31.87609 1.000 37.70241  ? 26  SER A CA  1 
ATOM   134  C C   . SER A 1 18  ? 24.78735  -4.26460  32.82950 1.000 38.53073  ? 26  SER A C   1 
ATOM   135  O O   . SER A 1 18  ? 25.53093  -4.47413  33.79764 1.000 37.02345  ? 26  SER A O   1 
ATOM   136  C CB  . SER A 1 18  ? 25.76401  -5.86525  31.19763 1.000 34.95046  ? 26  SER A CB  1 
ATOM   137  O OG  . SER A 1 18  ? 26.37249  -4.79332  30.48756 1.000 35.89497  ? 26  SER A OG  1 
ATOM   138  N N   . HIS A 1 19  ? 24.28097  -3.06238  32.58311 1.000 41.98174  ? 27  HIS A N   1 
ATOM   139  C CA  . HIS A 1 19  ? 24.62878  -1.96241  33.46863 1.000 40.00019  ? 27  HIS A CA  1 
ATOM   140  C C   . HIS A 1 19  ? 23.79352  -1.94705  34.74663 1.000 44.01912  ? 27  HIS A C   1 
ATOM   141  O O   . HIS A 1 19  ? 24.14083  -1.22052  35.68013 1.000 44.61356  ? 27  HIS A O   1 
ATOM   142  C CB  . HIS A 1 19  ? 24.50300  -0.63991  32.71795 1.000 36.71037  ? 27  HIS A CB  1 
ATOM   143  C CG  . HIS A 1 19  ? 23.10744  -0.27833  32.33184 1.000 39.84624  ? 27  HIS A CG  1 
ATOM   144  N ND1 . HIS A 1 19  ? 22.46996  -0.82678  31.23949 1.000 38.66144  ? 27  HIS A ND1 1 
ATOM   145  C CD2 . HIS A 1 19  ? 22.25447  0.64342   32.83868 1.000 42.77398  ? 27  HIS A CD2 1 
ATOM   146  C CE1 . HIS A 1 19  ? 21.26992  -0.29002  31.11530 1.000 38.52103  ? 27  HIS A CE1 1 
ATOM   147  N NE2 . HIS A 1 19  ? 21.11631  0.60894   32.06967 1.000 40.99542  ? 27  HIS A NE2 1 
ATOM   148  N N   . GLY A 1 20  ? 22.73348  -2.75781  34.83387 1.000 39.40207  ? 28  GLY A N   1 
ATOM   149  C CA  . GLY A 1 20  ? 21.87536  -2.77555  35.99914 1.000 40.89902  ? 28  GLY A CA  1 
ATOM   150  C C   . GLY A 1 20  ? 21.69264  -4.17907  36.54607 1.000 40.52152  ? 28  GLY A C   1 
ATOM   151  O O   . GLY A 1 20  ? 22.28326  -5.14143  36.05423 1.000 37.94153  ? 28  GLY A O   1 
ATOM   152  N N   . VAL A 1 21  ? 20.87515  -4.26083  37.59476 1.000 39.77905  ? 29  VAL A N   1 
ATOM   153  C CA  . VAL A 1 21  ? 20.58344  -5.50425  38.29845 1.000 40.02029  ? 29  VAL A CA  1 
ATOM   154  C C   . VAL A 1 21  ? 19.07206  -5.54418  38.52341 1.000 39.84245  ? 29  VAL A C   1 
ATOM   155  O O   . VAL A 1 21  ? 18.46790  -4.51912  38.84859 1.000 40.91052  ? 29  VAL A O   1 
ATOM   156  C CB  . VAL A 1 21  ? 21.34406  -5.58555  39.64276 1.000 39.92835  ? 29  VAL A CB  1 
ATOM   157  C CG1 . VAL A 1 21  ? 20.78812  -6.68386  40.54121 1.000 36.61894  ? 29  VAL A CG1 1 
ATOM   158  C CG2 . VAL A 1 21  ? 22.85654  -5.76296  39.39764 1.000 41.54430  ? 29  VAL A CG2 1 
ATOM   159  N N   . LEU A 1 22  ? 18.46602  -6.71668  38.34862 1.000 41.51062  ? 30  LEU A N   1 
ATOM   160  C CA  . LEU A 1 22  ? 17.02736  -6.90717  38.50608 1.000 44.19773  ? 30  LEU A CA  1 
ATOM   161  C C   . LEU A 1 22  ? 16.75811  -8.00331  39.52841 1.000 40.95583  ? 30  LEU A C   1 
ATOM   162  O O   . LEU A 1 22  ? 17.38275  -9.06816  39.49708 1.000 37.84330  ? 30  LEU A O   1 
ATOM   163  C CB  . LEU A 1 22  ? 16.35970  -7.26997  37.16717 1.000 37.64986  ? 30  LEU A CB  1 
ATOM   164  C CG  . LEU A 1 22  ? 14.84596  -7.53049  37.07535 1.000 41.21706  ? 30  LEU A CG  1 
ATOM   165  C CD1 . LEU A 1 22  ? 14.28398  -7.08965  35.71622 1.000 36.42426  ? 30  LEU A CD1 1 
ATOM   166  C CD2 . LEU A 1 22  ? 14.49857  -9.00858  37.33019 1.000 35.97532  ? 30  LEU A CD2 1 
ATOM   167  N N   . LEU A 1 23  ? 15.81406  -7.73006  40.42615 1.000 42.32591  ? 31  LEU A N   1 
ATOM   168  C CA  . LEU A 1 23  ? 15.31576  -8.70566  41.38367 1.000 45.87789  ? 31  LEU A CA  1 
ATOM   169  C C   . LEU A 1 23  ? 13.79553  -8.73342  41.30583 1.000 49.03253  ? 31  LEU A C   1 
ATOM   170  O O   . LEU A 1 23  ? 13.15517  -7.70590  41.04580 1.000 45.93950  ? 31  LEU A O   1 
ATOM   171  C CB  . LEU A 1 23  ? 15.76680  -8.36518  42.81567 1.000 46.32126  ? 31  LEU A CB  1 
ATOM   172  C CG  . LEU A 1 23  ? 17.28299  -8.31479  43.05998 1.000 49.47852  ? 31  LEU A CG  1 
ATOM   173  C CD1 . LEU A 1 23  ? 17.86884  -6.94318  42.73136 1.000 47.35898  ? 31  LEU A CD1 1 
ATOM   174  C CD2 . LEU A 1 23  ? 17.60274  -8.69341  44.48164 1.000 53.60246  ? 31  LEU A CD2 1 
ATOM   175  N N   . ALA A 1 24  ? 13.21589  -9.91802  41.51435 1.000 50.40397  ? 32  ALA A N   1 
ATOM   176  C CA  . ALA A 1 24  ? 11.76493  -10.04299 41.59644 1.000 53.09415  ? 32  ALA A CA  1 
ATOM   177  C C   . ALA A 1 24  ? 11.39250  -10.96099 42.75366 1.000 53.99698  ? 32  ALA A C   1 
ATOM   178  O O   . ALA A 1 24  ? 12.10491  -11.91995 43.05701 1.000 53.74564  ? 32  ALA A O   1 
ATOM   179  C CB  . ALA A 1 24  ? 11.15872  -10.56837 40.28584 1.000 52.62842  ? 32  ALA A CB  1 
ATOM   180  N N   . PHE A 1 25  ? 10.26237  -10.65797 43.39760 1.000 57.53811  ? 33  PHE A N   1 
ATOM   181  C CA  . PHE A 1 25  ? 9.81212   -11.41651 44.56082 1.000 63.11398  ? 33  PHE A CA  1 
ATOM   182  C C   . PHE A 1 25  ? 8.29638   -11.32786 44.71098 1.000 61.02046  ? 33  PHE A C   1 
ATOM   183  O O   . PHE A 1 25  ? 7.67619   -10.31731 44.36711 1.000 57.61024  ? 33  PHE A O   1 
ATOM   184  C CB  . PHE A 1 25  ? 10.51225  -10.93587 45.83941 1.000 62.78172  ? 33  PHE A CB  1 
ATOM   185  C CG  . PHE A 1 25  ? 10.81108  -9.46622  45.86091 1.000 61.92205  ? 33  PHE A CG  1 
ATOM   186  C CD1 . PHE A 1 25  ? 9.96688   -8.58121  46.50915 1.000 66.17218  ? 33  PHE A CD1 1 
ATOM   187  C CD2 . PHE A 1 25  ? 11.95903  -8.96898  45.25034 1.000 61.55111  ? 33  PHE A CD2 1 
ATOM   188  C CE1 . PHE A 1 25  ? 10.26106  -7.21603  46.54020 1.000 67.44722  ? 33  PHE A CE1 1 
ATOM   189  C CE2 . PHE A 1 25  ? 12.25855  -7.61503  45.26602 1.000 60.91165  ? 33  PHE A CE2 1 
ATOM   190  C CZ  . PHE A 1 25  ? 11.41219  -6.73502  45.90938 1.000 64.12830  ? 33  PHE A CZ  1 
ATOM   191  N N   . ARG A 1 26  ? 7.70609   -12.39694 45.23622 1.000 68.41860  ? 34  ARG A N   1 
ATOM   192  C CA  . ARG A 1 26  ? 6.26400   -12.47603 45.46757 1.000 73.47109  ? 34  ARG A CA  1 
ATOM   193  C C   . ARG A 1 26  ? 5.98220   -12.57298 46.96152 1.000 73.35216  ? 34  ARG A C   1 
ATOM   194  O O   . ARG A 1 26  ? 6.89114   -12.70544 47.78771 1.000 71.23572  ? 34  ARG A O   1 
ATOM   195  C CB  . ARG A 1 26  ? 5.65680   -13.69292 44.75655 1.000 73.45504  ? 34  ARG A CB  1 
ATOM   196  C CG  . ARG A 1 26  ? 5.92363   -14.97618 45.52716 1.000 80.21387  ? 34  ARG A CG  1 
ATOM   197  C CD  . ARG A 1 26  ? 5.63130   -16.24263 44.74755 1.000 84.95342  ? 34  ARG A CD  1 
ATOM   198  N NE  . ARG A 1 26  ? 6.45719   -17.33619 45.25400 1.000 85.40859  ? 34  ARG A NE  1 
ATOM   199  C CZ  . ARG A 1 26  ? 5.98746   -18.38409 45.91987 1.000 90.21518  ? 34  ARG A CZ  1 
ATOM   200  N NH1 . ARG A 1 26  ? 4.68828   -18.54898 46.12292 1.000 89.39260  ? 34  ARG A NH1 1 
ATOM   201  N NH2 . ARG A 1 26  ? 6.84092   -19.29762 46.37812 1.000 91.66758  ? 34  ARG A NH2 1 
ATOM   202  N N   . GLY A 1 27  ? 4.69271   -12.54505 47.29139 1.000 76.91684  ? 35  GLY A N   1 
ATOM   203  C CA  . GLY A 1 27  ? 4.23040   -12.91547 48.60528 1.000 75.60186  ? 35  GLY A CA  1 
ATOM   204  C C   . GLY A 1 27  ? 4.56445   -11.90854 49.68344 1.000 76.43285  ? 35  GLY A C   1 
ATOM   205  O O   . GLY A 1 27  ? 5.31139   -10.94696 49.46954 1.000 76.96490  ? 35  GLY A O   1 
ATOM   206  N N   . PRO A 1 28  ? 3.96838   -12.08992 50.86465 1.000 80.08881  ? 36  PRO A N   1 
ATOM   207  C CA  . PRO A 1 28  ? 4.29584   -11.20106 51.99297 1.000 82.28478  ? 36  PRO A CA  1 
ATOM   208  C C   . PRO A 1 28  ? 5.66420   -11.46492 52.60873 1.000 80.67445  ? 36  PRO A C   1 
ATOM   209  O O   . PRO A 1 28  ? 6.23594   -10.55389 53.22559 1.000 79.44725  ? 36  PRO A O   1 
ATOM   210  C CB  . PRO A 1 28  ? 3.16412   -11.47594 52.99578 1.000 77.35132  ? 36  PRO A CB  1 
ATOM   211  C CG  . PRO A 1 28  ? 2.04946   -12.04742 52.16033 1.000 75.83740  ? 36  PRO A CG  1 
ATOM   212  C CD  . PRO A 1 28  ? 2.73573   -12.85938 51.10353 1.000 77.30999  ? 36  PRO A CD  1 
ATOM   213  N N   . ASP A 1 29  ? 6.21573   -12.67103 52.45611 1.000 82.06579  ? 37  ASP A N   1 
ATOM   214  C CA  . ASP A 1 29  ? 7.58906   -12.90623 52.88921 1.000 80.98230  ? 37  ASP A CA  1 
ATOM   215  C C   . ASP A 1 29  ? 8.59178   -12.20507 51.98271 1.000 80.28402  ? 37  ASP A C   1 
ATOM   216  O O   . ASP A 1 29  ? 9.75679   -12.05184 52.37191 1.000 79.33078  ? 37  ASP A O   1 
ATOM   217  C CB  . ASP A 1 29  ? 7.88535   -14.40993 52.92354 1.000 82.45950  ? 37  ASP A CB  1 
ATOM   218  C CG  . ASP A 1 29  ? 6.95367   -15.17584 53.85722 1.000 85.98269  ? 37  ASP A CG  1 
ATOM   219  O OD1 . ASP A 1 29  ? 6.36408   -14.55296 54.76925 1.000 88.03579  ? 37  ASP A OD1 1 
ATOM   220  O OD2 . ASP A 1 29  ? 6.79200   -16.40005 53.65755 1.000 86.08256  ? 37  ASP A OD2 1 
ATOM   221  N N   . ARG A 1 30  ? 8.15851   -11.78623 50.78661 1.000 78.16278  ? 38  ARG A N   1 
ATOM   222  C CA  . ARG A 1 30  ? 9.00230   -11.11610 49.79965 1.000 69.85888  ? 38  ARG A CA  1 
ATOM   223  C C   . ARG A 1 30  ? 10.18073  -12.00864 49.39811 1.000 69.08780  ? 38  ARG A C   1 
ATOM   224  O O   . ARG A 1 30  ? 11.34615  -11.62562 49.49003 1.000 71.47610  ? 38  ARG A O   1 
ATOM   225  C CB  . ARG A 1 30  ? 9.48488   -9.76138  50.32634 1.000 71.17249  ? 38  ARG A CB  1 
ATOM   226  C CG  . ARG A 1 30  ? 8.39807   -8.75467  50.66072 1.000 69.97457  ? 38  ARG A CG  1 
ATOM   227  C CD  . ARG A 1 30  ? 7.50687   -8.47975  49.46905 1.000 73.49778  ? 38  ARG A CD  1 
ATOM   228  N NE  . ARG A 1 30  ? 7.12054   -7.07457  49.36281 1.000 71.18480  ? 38  ARG A NE  1 
ATOM   229  C CZ  . ARG A 1 30  ? 6.24208   -6.61448  48.48052 1.000 66.50969  ? 38  ARG A CZ  1 
ATOM   230  N NH1 . ARG A 1 30  ? 5.63354   -7.42503  47.63222 1.000 67.71665  ? 38  ARG A NH1 1 
ATOM   231  N NH2 . ARG A 1 30  ? 5.96478   -5.31216  48.45205 1.000 60.58346  ? 38  ARG A NH2 1 
ATOM   232  N N   . LEU A 1 31  ? 9.85704   -13.21422 48.94200 1.000 71.63787  ? 39  LEU A N   1 
ATOM   233  C CA  . LEU A 1 31  ? 10.86707  -14.22445 48.64179 1.000 73.17566  ? 39  LEU A CA  1 
ATOM   234  C C   . LEU A 1 31  ? 11.39432  -14.04119 47.22377 1.000 67.23112  ? 39  LEU A C   1 
ATOM   235  O O   . LEU A 1 31  ? 10.61902  -14.05865 46.26116 1.000 66.30712  ? 39  LEU A O   1 
ATOM   236  C CB  . LEU A 1 31  ? 10.29212  -15.63411 48.80300 1.000 72.67449  ? 39  LEU A CB  1 
ATOM   237  C CG  . LEU A 1 31  ? 9.66102   -16.00312 50.14818 1.000 76.86449  ? 39  LEU A CG  1 
ATOM   238  C CD1 . LEU A 1 31  ? 9.02237   -17.38233 50.06215 1.000 76.92395  ? 39  LEU A CD1 1 
ATOM   239  C CD2 . LEU A 1 31  ? 10.68611  -15.94395 51.27054 1.000 74.19844  ? 39  LEU A CD2 1 
ATOM   240  N N   . LEU A 1 32  ? 12.71104  -13.90423 47.09761 1.000 65.43985  ? 40  LEU A N   1 
ATOM   241  C CA  . LEU A 1 32  ? 13.33594  -13.76609 45.78724 1.000 61.90035  ? 40  LEU A CA  1 
ATOM   242  C C   . LEU A 1 32  ? 12.95964  -14.93999 44.89955 1.000 60.60341  ? 40  LEU A C   1 
ATOM   243  O O   . LEU A 1 32  ? 13.18076  -16.09666 45.26420 1.000 61.27511  ? 40  LEU A O   1 
ATOM   244  C CB  . LEU A 1 32  ? 14.85591  -13.70453 45.92583 1.000 64.63731  ? 40  LEU A CB  1 
ATOM   245  C CG  . LEU A 1 32  ? 15.53102  -12.34301 45.84211 1.000 62.06206  ? 40  LEU A CG  1 
ATOM   246  C CD1 . LEU A 1 32  ? 15.22040  -11.72007 44.48615 1.000 57.92638  ? 40  LEU A CD1 1 
ATOM   247  C CD2 . LEU A 1 32  ? 15.11832  -11.43358 46.98900 1.000 66.65193  ? 40  LEU A CD2 1 
ATOM   248  N N   . GLU A 1 33  ? 12.36740  -14.64538 43.74692 1.000 61.84045  ? 41  GLU A N   1 
ATOM   249  C CA  . GLU A 1 33  ? 12.09120  -15.65860 42.73907 1.000 56.99195  ? 41  GLU A CA  1 
ATOM   250  C C   . GLU A 1 33  ? 12.85051  -15.45158 41.44233 1.000 50.32836  ? 41  GLU A C   1 
ATOM   251  O O   . GLU A 1 33  ? 13.07635  -16.42202 40.72458 1.000 53.53490  ? 41  GLU A O   1 
ATOM   252  C CB  . GLU A 1 33  ? 10.58272  -15.72884 42.42746 1.000 61.36612  ? 41  GLU A CB  1 
ATOM   253  C CG  . GLU A 1 33  ? 10.11226  -17.13179 42.02286 1.000 64.57426  ? 41  GLU A CG  1 
ATOM   254  C CD  . GLU A 1 33  ? 8.70542   -17.45633 42.49495 1.000 73.58505  ? 41  GLU A CD  1 
ATOM   255  O OE1 . GLU A 1 33  ? 8.34625   -17.05259 43.62042 1.000 77.41755  ? 41  GLU A OE1 1 
ATOM   256  O OE2 . GLU A 1 33  ? 7.95415   -18.11253 41.73851 1.000 74.35789  ? 41  GLU A OE2 1 
ATOM   257  N N   . VAL A 1 34  ? 13.23366  -14.22354 41.10807 1.000 49.13417  ? 42  VAL A N   1 
ATOM   258  C CA  . VAL A 1 34  ? 14.00117  -13.94007 39.89794 1.000 50.32711  ? 42  VAL A CA  1 
ATOM   259  C C   . VAL A 1 34  ? 15.20364  -13.08591 40.28695 1.000 48.05462  ? 42  VAL A C   1 
ATOM   260  O O   . VAL A 1 34  ? 15.08454  -12.18492 41.12417 1.000 46.19823  ? 42  VAL A O   1 
ATOM   261  C CB  . VAL A 1 34  ? 13.14434  -13.22024 38.82223 1.000 50.10274  ? 42  VAL A CB  1 
ATOM   262  C CG1 . VAL A 1 34  ? 13.90052  -13.13771 37.49474 1.000 44.52669  ? 42  VAL A CG1 1 
ATOM   263  C CG2 . VAL A 1 34  ? 11.81251  -13.90936 38.63533 1.000 44.31543  ? 42  VAL A CG2 1 
ATOM   264  N N   . VAL A 1 35  ? 16.35546  -13.35412 39.67640 1.000 41.68541  ? 43  VAL A N   1 
ATOM   265  C CA  . VAL A 1 35  ? 17.54631  -12.54382 39.93854 1.000 46.61973  ? 43  VAL A CA  1 
ATOM   266  C C   . VAL A 1 35  ? 18.47872  -12.60620 38.73669 1.000 40.15685  ? 43  VAL A C   1 
ATOM   267  O O   . VAL A 1 35  ? 18.73345  -13.67848 38.18604 1.000 42.30457  ? 43  VAL A O   1 
ATOM   268  C CB  . VAL A 1 35  ? 18.27035  -12.98221 41.22842 1.000 47.93164  ? 43  VAL A CB  1 
ATOM   269  C CG1 . VAL A 1 35  ? 18.87383  -14.39436 41.08328 1.000 46.26771  ? 43  VAL A CG1 1 
ATOM   270  C CG2 . VAL A 1 35  ? 19.30905  -11.95615 41.64335 1.000 47.10663  ? 43  VAL A CG2 1 
ATOM   271  N N   . SER A 1 36  ? 18.98721  -11.45143 38.32529 1.000 40.63146  ? 44  SER A N   1 
ATOM   272  C CA  . SER A 1 36  ? 19.91539  -11.42386 37.20741 1.000 38.95010  ? 44  SER A CA  1 
ATOM   273  C C   . SER A 1 36  ? 21.24426  -12.05384 37.61318 1.000 40.55923  ? 44  SER A C   1 
ATOM   274  O O   . SER A 1 36  ? 21.69987  -11.91072 38.74957 1.000 37.67853  ? 44  SER A O   1 
ATOM   275  C CB  . SER A 1 36  ? 20.13018  -9.98613  36.73341 1.000 40.91799  ? 44  SER A CB  1 
ATOM   276  O OG  . SER A 1 36  ? 20.53559  -9.12224  37.78734 1.000 38.70503  ? 44  SER A OG  1 
ATOM   277  N N   . ALA A 1 37  ? 21.87347  -12.74518 36.66527 1.000 41.00417  ? 45  ALA A N   1 
ATOM   278  C CA  . ALA A 1 37  ? 23.05398  -13.53219 36.98242 1.000 37.80587  ? 45  ALA A CA  1 
ATOM   279  C C   . ALA A 1 37  ? 24.23723  -12.67163 37.40069 1.000 41.46739  ? 45  ALA A C   1 
ATOM   280  O O   . ALA A 1 37  ? 25.18464  -13.20430 37.98736 1.000 39.40168  ? 45  ALA A O   1 
ATOM   281  C CB  . ALA A 1 37  ? 23.43232  -14.38912 35.77816 1.000 35.51312  ? 45  ALA A CB  1 
ATOM   282  N N   . ASN A 1 38  ? 24.19288  -11.36185 37.12764 1.000 38.66305  ? 46  ASN A N   1 
ATOM   283  C CA  . ASN A 1 38  ? 25.25408  -10.41663 37.45630 1.000 40.75554  ? 46  ASN A CA  1 
ATOM   284  C C   . ASN A 1 38  ? 25.09347  -9.81652  38.85054 1.000 43.30939  ? 46  ASN A C   1 
ATOM   285  O O   . ASN A 1 38  ? 25.83536  -8.88641  39.20029 1.000 43.53720  ? 46  ASN A O   1 
ATOM   286  C CB  . ASN A 1 38  ? 25.28659  -9.26990  36.42056 1.000 39.47299  ? 46  ASN A CB  1 
ATOM   287  C CG  . ASN A 1 38  ? 24.00510  -8.41799  36.46072 1.000 38.77221  ? 46  ASN A CG  1 
ATOM   288  O OD1 . ASN A 1 38  ? 23.01913  -8.82101  37.07082 1.000 38.29627  ? 46  ASN A OD1 1 
ATOM   289  N ND2 . ASN A 1 38  ? 24.02818  -7.24292  35.83912 1.000 35.37850  ? 46  ASN A ND2 1 
ATOM   290  N N   . ALA A 1 39  ? 24.14068  -10.31320 39.64962 1.000 40.68180  ? 47  ALA A N   1 
ATOM   291  C CA  . ALA A 1 39  ? 23.77069  -9.61637  40.87738 1.000 40.60186  ? 47  ALA A CA  1 
ATOM   292  C C   . ALA A 1 39  ? 24.84260  -9.66043  41.96940 1.000 42.00144  ? 47  ALA A C   1 
ATOM   293  O O   . ALA A 1 39  ? 24.78043  -8.85272  42.90274 1.000 43.98183  ? 47  ALA A O   1 
ATOM   294  C CB  . ALA A 1 39  ? 22.46738  -10.19172 41.43314 1.000 41.29981  ? 47  ALA A CB  1 
ATOM   295  N N   . GLN A 1 40  ? 25.81202  -10.57587 41.91579 1.000 41.06807  ? 48  GLN A N   1 
ATOM   296  C CA  . GLN A 1 40  ? 26.71834  -10.64604 43.06199 1.000 47.55349  ? 48  GLN A CA  1 
ATOM   297  C C   . GLN A 1 40  ? 27.57758  -9.38595  43.19147 1.000 45.55987  ? 48  GLN A C   1 
ATOM   298  O O   . GLN A 1 40  ? 27.85756  -8.94906  44.31323 1.000 45.24297  ? 48  GLN A O   1 
ATOM   299  C CB  . GLN A 1 40  ? 27.60608  -11.88919 43.02010 1.000 45.10945  ? 48  GLN A CB  1 
ATOM   300  C CG  . GLN A 1 40  ? 28.41376  -11.99296 44.31961 1.000 48.30628  ? 48  GLN A CG  1 
ATOM   301  C CD  . GLN A 1 40  ? 29.16686  -13.29349 44.50008 1.000 50.27015  ? 48  GLN A CD  1 
ATOM   302  O OE1 . GLN A 1 40  ? 29.07886  -14.21080 43.67581 1.000 49.94914  ? 48  GLN A OE1 1 
ATOM   303  N NE2 . GLN A 1 40  ? 29.89537  -13.38988 45.60775 1.000 46.24121  ? 48  GLN A NE2 1 
ATOM   304  N N   . ALA A 1 41  ? 27.97088  -8.76698  42.07185 1.000 45.91671  ? 49  ALA A N   1 
ATOM   305  C CA  . ALA A 1 41  ? 28.84007  -7.59047  42.14700 1.000 51.24183  ? 49  ALA A CA  1 
ATOM   306  C C   . ALA A 1 41  ? 28.23160  -6.46707  42.97237 1.000 50.25944  ? 49  ALA A C   1 
ATOM   307  O O   . ALA A 1 41  ? 28.97212  -5.63350  43.51348 1.000 54.10533  ? 49  ALA A O   1 
ATOM   308  C CB  . ALA A 1 41  ? 29.16229  -7.06616  40.74353 1.000 44.31947  ? 49  ALA A CB  1 
ATOM   309  N N   . LEU A 1 42  ? 26.90889  -6.44789  43.11485 1.000 48.93275  ? 50  LEU A N   1 
ATOM   310  C CA  . LEU A 1 42  ? 26.21322  -5.40839  43.85642 1.000 46.38095  ? 50  LEU A CA  1 
ATOM   311  C C   . LEU A 1 42  ? 25.69268  -5.86464  45.21037 1.000 49.63600  ? 50  LEU A C   1 
ATOM   312  O O   . LEU A 1 42  ? 25.59349  -5.04379  46.12607 1.000 49.64542  ? 50  LEU A O   1 
ATOM   313  C CB  . LEU A 1 42  ? 25.03085  -4.87960  43.03071 1.000 52.35318  ? 50  LEU A CB  1 
ATOM   314  C CG  . LEU A 1 42  ? 24.57448  -3.44109  43.28125 1.000 51.60402  ? 50  LEU A CG  1 
ATOM   315  C CD1 . LEU A 1 42  ? 25.77811  -2.48475  43.28087 1.000 46.68737  ? 50  LEU A CD1 1 
ATOM   316  C CD2 . LEU A 1 42  ? 23.51044  -3.01601  42.26451 1.000 49.91393  ? 50  LEU A CD2 1 
ATOM   317  N N   . LEU A 1 43  ? 25.34330  -7.14362  45.35626 1.000 45.26460  ? 51  LEU A N   1 
ATOM   318  C CA  . LEU A 1 43  ? 24.67360  -7.63041  46.55073 1.000 47.88020  ? 51  LEU A CA  1 
ATOM   319  C C   . LEU A 1 43  ? 25.55119  -8.48870  47.44768 1.000 51.99640  ? 51  LEU A C   1 
ATOM   320  O O   . LEU A 1 43  ? 25.13142  -8.80346  48.56938 1.000 51.91580  ? 51  LEU A O   1 
ATOM   321  C CB  . LEU A 1 43  ? 23.42375  -8.44858  46.16560 1.000 47.35122  ? 51  LEU A CB  1 
ATOM   322  C CG  . LEU A 1 43  ? 22.37508  -7.79120  45.24954 1.000 46.79847  ? 51  LEU A CG  1 
ATOM   323  C CD1 . LEU A 1 43  ? 21.16666  -8.69326  45.04425 1.000 49.07389  ? 51  LEU A CD1 1 
ATOM   324  C CD2 . LEU A 1 43  ? 21.95279  -6.41131  45.75356 1.000 50.83319  ? 51  LEU A CD2 1 
ATOM   325  N N   . GLY A 1 44  ? 26.73475  -8.90044  46.98816 1.000 53.62613  ? 52  GLY A N   1 
ATOM   326  C CA  . GLY A 1 44  ? 27.67875  -9.57431  47.86496 1.000 49.18145  ? 52  GLY A CA  1 
ATOM   327  C C   . GLY A 1 44  ? 27.41574  -11.04604 48.10593 1.000 53.29357  ? 52  GLY A C   1 
ATOM   328  O O   . GLY A 1 44  ? 28.09286  -11.64954 48.94658 1.000 54.73729  ? 52  GLY A O   1 
ATOM   329  N N   . ARG A 1 45  ? 26.44502  -11.64253 47.42901 1.000 50.56956  ? 53  ARG A N   1 
ATOM   330  C CA  . ARG A 1 45  ? 26.21424  -13.07109 47.54483 1.000 49.15151  ? 53  ARG A CA  1 
ATOM   331  C C   . ARG A 1 45  ? 25.98448  -13.61876 46.14555 1.000 50.04974  ? 53  ARG A C   1 
ATOM   332  O O   . ARG A 1 45  ? 25.62636  -12.86794 45.23543 1.000 54.11479  ? 53  ARG A O   1 
ATOM   333  C CB  . ARG A 1 45  ? 25.00652  -13.36572 48.44620 1.000 57.22213  ? 53  ARG A CB  1 
ATOM   334  C CG  . ARG A 1 45  ? 25.09344  -12.75461 49.84589 1.000 60.08802  ? 53  ARG A CG  1 
ATOM   335  C CD  . ARG A 1 45  ? 25.41733  -13.76023 50.95597 1.000 70.58915  ? 53  ARG A CD  1 
ATOM   336  N NE  . ARG A 1 45  ? 26.21233  -13.11110 51.99865 1.000 81.69632  ? 53  ARG A NE  1 
ATOM   337  C CZ  . ARG A 1 45  ? 26.15475  -13.38792 53.29669 1.000 82.75529  ? 53  ARG A CZ  1 
ATOM   338  N NH1 . ARG A 1 45  ? 25.33060  -14.30843 53.77557 1.000 76.42491  ? 53  ARG A NH1 1 
ATOM   339  N NH2 . ARG A 1 45  ? 26.93616  -12.71240 54.13731 1.000 83.19202  ? 53  ARG A NH2 1 
ATOM   340  N N   . PRO A 1 46  ? 26.18608  -14.92100 45.94368 1.000 51.18193  ? 54  PRO A N   1 
ATOM   341  C CA  . PRO A 1 46  ? 25.90917  -15.49724 44.62695 1.000 53.67629  ? 54  PRO A CA  1 
ATOM   342  C C   . PRO A 1 46  ? 24.41528  -15.58001 44.37660 1.000 57.32660  ? 54  PRO A C   1 
ATOM   343  O O   . PRO A 1 46  ? 23.63067  -15.82175 45.30762 1.000 57.82671  ? 54  PRO A O   1 
ATOM   344  C CB  . PRO A 1 46  ? 26.53801  -16.90152 44.71693 1.000 52.75877  ? 54  PRO A CB  1 
ATOM   345  C CG  . PRO A 1 46  ? 27.37865  -16.88870 45.96195 1.000 53.31121  ? 54  PRO A CG  1 
ATOM   346  C CD  . PRO A 1 46  ? 26.73817  -15.90982 46.87668 1.000 51.82845  ? 54  PRO A CD  1 
ATOM   347  N N   . PRO A 1 47  ? 23.97180  -15.41730 43.11999 1.000 58.94777  ? 55  PRO A N   1 
ATOM   348  C CA  . PRO A 1 47  ? 22.51872  -15.37310 42.85162 1.000 55.92222  ? 55  PRO A CA  1 
ATOM   349  C C   . PRO A 1 47  ? 21.75464  -16.61952 43.28140 1.000 60.81075  ? 55  PRO A C   1 
ATOM   350  O O   . PRO A 1 47  ? 20.66408  -16.48773 43.85912 1.000 61.73665  ? 55  PRO A O   1 
ATOM   351  C CB  . PRO A 1 47  ? 22.45687  -15.14985 41.33479 1.000 50.23479  ? 55  PRO A CB  1 
ATOM   352  C CG  . PRO A 1 47  ? 23.75661  -14.47622 41.00302 1.000 54.81896  ? 55  PRO A CG  1 
ATOM   353  C CD  . PRO A 1 47  ? 24.76742  -15.10007 41.92161 1.000 56.77856  ? 55  PRO A CD  1 
ATOM   354  N N   . GLU A 1 48  ? 22.27903  -17.82252 43.00781 1.000 60.86917  ? 56  GLU A N   1 
ATOM   355  C CA  . GLU A 1 48  ? 21.60857  -19.04298 43.45930 1.000 61.93548  ? 56  GLU A CA  1 
ATOM   356  C C   . GLU A 1 48  ? 21.45141  -19.07583 44.96857 1.000 60.00165  ? 56  GLU A C   1 
ATOM   357  O O   . GLU A 1 48  ? 20.50791  -19.68357 45.48055 1.000 66.55346  ? 56  GLU A O   1 
ATOM   358  C CB  . GLU A 1 48  ? 22.37243  -20.28599 43.01138 1.000 61.21846  ? 56  GLU A CB  1 
ATOM   359  C CG  . GLU A 1 48  ? 21.71483  -21.05465 41.88566 1.000 63.87574  ? 56  GLU A CG  1 
ATOM   360  C CD  . GLU A 1 48  ? 21.64933  -20.25953 40.60712 1.000 65.67760  ? 56  GLU A CD  1 
ATOM   361  O OE1 . GLU A 1 48  ? 20.65414  -20.41120 39.85818 1.000 68.46557  ? 56  GLU A OE1 1 
ATOM   362  O OE2 . GLU A 1 48  ? 22.59926  -19.48276 40.35103 1.000 68.90463  ? 56  GLU A OE2 1 
ATOM   363  N N   . THR A 1 49  ? 22.33868  -18.40268 45.68813 1.000 58.45207  ? 57  THR A N   1 
ATOM   364  C CA  . THR A 1 49  ? 22.21314  -18.30657 47.13320 1.000 58.35136  ? 57  THR A CA  1 
ATOM   365  C C   . THR A 1 49  ? 21.07915  -17.36326 47.52595 1.000 61.89342  ? 57  THR A C   1 
ATOM   366  O O   . THR A 1 49  ? 20.33174  -17.63915 48.47079 1.000 63.62551  ? 57  THR A O   1 
ATOM   367  C CB  . THR A 1 49  ? 23.55306  -17.83949 47.70804 1.000 58.87004  ? 57  THR A CB  1 
ATOM   368  O OG1 . THR A 1 49  ? 24.51669  -18.88612 47.55704 1.000 63.86912  ? 57  THR A OG1 1 
ATOM   369  C CG2 . THR A 1 49  ? 23.44010  -17.46016 49.18400 1.000 63.47108  ? 57  THR A CG2 1 
ATOM   370  N N   . LEU A 1 50  ? 20.93193  -16.24079 46.81949 1.000 60.43532  ? 58  LEU A N   1 
ATOM   371  C CA  . LEU A 1 50  ? 19.90908  -15.27627 47.20892 1.000 63.21778  ? 58  LEU A CA  1 
ATOM   372  C C   . LEU A 1 50  ? 18.49360  -15.76650 46.89942 1.000 61.43340  ? 58  LEU A C   1 
ATOM   373  O O   . LEU A 1 50  ? 17.53663  -15.28070 47.51698 1.000 62.19510  ? 58  LEU A O   1 
ATOM   374  C CB  . LEU A 1 50  ? 20.16741  -13.92545 46.54258 1.000 60.95243  ? 58  LEU A CB  1 
ATOM   375  C CG  . LEU A 1 50  ? 21.54485  -13.29112 46.79522 1.000 61.42434  ? 58  LEU A CG  1 
ATOM   376  C CD1 . LEU A 1 50  ? 22.25916  -12.95551 45.48208 1.000 58.64101  ? 58  LEU A CD1 1 
ATOM   377  C CD2 . LEU A 1 50  ? 21.45637  -12.05885 47.69461 1.000 61.16929  ? 58  LEU A CD2 1 
ATOM   378  N N   . LEU A 1 51  ? 18.33738  -16.71106 45.97142 1.000 57.31851  ? 59  LEU A N   1 
ATOM   379  C CA  . LEU A 1 51  ? 17.01893  -17.26635 45.67977 1.000 64.03520  ? 59  LEU A CA  1 
ATOM   380  C C   . LEU A 1 51  ? 16.40351  -17.87735 46.93483 1.000 66.46045  ? 59  LEU A C   1 
ATOM   381  O O   . LEU A 1 51  ? 17.07274  -18.57908 47.69919 1.000 68.53368  ? 59  LEU A O   1 
ATOM   382  C CB  . LEU A 1 51  ? 17.11747  -18.33182 44.58144 1.000 62.19424  ? 59  LEU A CB  1 
ATOM   383  C CG  . LEU A 1 51  ? 17.33359  -17.86578 43.13936 1.000 64.53701  ? 59  LEU A CG  1 
ATOM   384  C CD1 . LEU A 1 51  ? 17.53808  -19.05379 42.19819 1.000 60.88990  ? 59  LEU A CD1 1 
ATOM   385  C CD2 . LEU A 1 51  ? 16.14911  -17.00422 42.67988 1.000 57.97879  ? 59  LEU A CD2 1 
ATOM   386  N N   . GLY A 1 52  ? 15.11712  -17.59941 47.14852 1.000 63.68374  ? 60  GLY A N   1 
ATOM   387  C CA  . GLY A 1 52  ? 14.40282  -18.08124 48.30743 1.000 63.25252  ? 60  GLY A CA  1 
ATOM   388  C C   . GLY A 1 52  ? 14.42199  -17.13741 49.48862 1.000 66.89315  ? 60  GLY A C   1 
ATOM   389  O O   . GLY A 1 52  ? 13.61906  -17.29671 50.41157 1.000 68.51439  ? 60  GLY A O   1 
ATOM   390  N N   . GLN A 1 53  ? 15.24941  -16.22687 49.48320 1.000 68.27491  ? 61  GLN A N   1 
ATOM   391  C CA  . GLN A 1 53  ? 15.49057  -15.36507 50.62235 1.000 64.78964  ? 61  GLN A CA  1 
ATOM   392  C C   . GLN A 1 53  ? 14.50877  -14.19558 50.63188 1.000 66.76089  ? 61  GLN A C   1 
ATOM   393  O O   . GLN A 1 53  ? 14.01434  -13.78076 49.58043 1.000 67.90519  ? 61  GLN A O   1 
ATOM   394  C CB  . GLN A 1 53  ? 16.92314  -14.84435 50.56811 1.000 66.51750  ? 61  GLN A CB  1 
ATOM   395  C CG  . GLN A 1 53  ? 17.46261  -14.27448 51.85269 1.000 68.67538  ? 61  GLN A CG  1 
ATOM   396  C CD  . GLN A 1 53  ? 18.20561  -15.29706 52.71498 1.000 73.44548  ? 61  GLN A CD  1 
ATOM   397  O OE1 . GLN A 1 53  ? 19.43852  -15.31940 52.74809 1.000 71.23123  ? 61  GLN A OE1 1 
ATOM   398  N NE2 . GLN A 1 53  ? 17.45316  -16.12543 53.43684 1.000 75.46313  ? 61  GLN A NE2 1 
ATOM   399  N N   . PRO A 1 54  ? 14.17100  -13.66260 51.80168 1.000 68.44907  ? 62  PRO A N   1 
ATOM   400  C CA  . PRO A 1 54  ? 13.41608  -12.40681 51.83706 1.000 69.09733  ? 62  PRO A CA  1 
ATOM   401  C C   . PRO A 1 54  ? 14.30651  -11.23254 51.48428 1.000 70.20234  ? 62  PRO A C   1 
ATOM   402  O O   . PRO A 1 54  ? 15.52411  -11.26089 51.68192 1.000 67.37197  ? 62  PRO A O   1 
ATOM   403  C CB  . PRO A 1 54  ? 12.92309  -12.31801 53.28816 1.000 70.81429  ? 62  PRO A CB  1 
ATOM   404  C CG  . PRO A 1 54  ? 13.05111  -13.72171 53.82897 1.000 74.93572  ? 62  PRO A CG  1 
ATOM   405  C CD  . PRO A 1 54  ? 14.22944  -14.30951 53.12474 1.000 69.95738  ? 62  PRO A CD  1 
ATOM   406  N N   . VAL A 1 55  ? 13.67961  -10.16596 50.98689 1.000 67.96368  ? 63  VAL A N   1 
ATOM   407  C CA  . VAL A 1 55  ? 14.47513  -9.04542  50.50515 1.000 66.56092  ? 63  VAL A CA  1 
ATOM   408  C C   . VAL A 1 55  ? 15.17239  -8.33511  51.65251 1.000 65.87089  ? 63  VAL A C   1 
ATOM   409  O O   . VAL A 1 55  ? 16.18699  -7.67156  51.42901 1.000 65.55800  ? 63  VAL A O   1 
ATOM   410  C CB  . VAL A 1 55  ? 13.60855  -8.06789  49.69608 1.000 67.48555  ? 63  VAL A CB  1 
ATOM   411  C CG1 . VAL A 1 55  ? 13.32315  -8.65851  48.32770 1.000 66.68914  ? 63  VAL A CG1 1 
ATOM   412  C CG2 . VAL A 1 55  ? 12.33671  -7.74934  50.43316 1.000 67.13620  ? 63  VAL A CG2 1 
ATOM   413  N N   . GLY A 1 56  ? 14.63679  -8.44266  52.87253 1.000 66.17564  ? 64  GLY A N   1 
ATOM   414  C CA  . GLY A 1 56  ? 15.26703  -7.80533  54.00915 1.000 68.82998  ? 64  GLY A CA  1 
ATOM   415  C C   . GLY A 1 56  ? 16.71887  -8.19895  54.21499 1.000 68.26518  ? 64  GLY A C   1 
ATOM   416  O O   . GLY A 1 56  ? 17.53697  -7.36808  54.62537 1.000 67.65435  ? 64  GLY A O   1 
ATOM   417  N N   . ARG A 1 57  ? 17.07748  -9.44747  53.91847 1.000 65.94789  ? 65  ARG A N   1 
ATOM   418  C CA  . ARG A 1 57  ? 18.47797  -9.84972  54.00256 1.000 70.65308  ? 65  ARG A CA  1 
ATOM   419  C C   . ARG A 1 57  ? 19.07797  -10.10337 52.61764 1.000 69.52510  ? 65  ARG A C   1 
ATOM   420  O O   . ARG A 1 57  ? 19.95775  -10.95306 52.45556 1.000 73.64427  ? 65  ARG A O   1 
ATOM   421  C CB  . ARG A 1 57  ? 18.66756  -11.06109 54.92167 1.000 71.08792  ? 65  ARG A CB  1 
ATOM   422  C CG  . ARG A 1 57  ? 18.01658  -12.33709 54.45788 1.000 71.91142  ? 65  ARG A CG  1 
ATOM   423  C CD  . ARG A 1 57  ? 18.03327  -13.49798 55.48928 1.000 78.01629  ? 65  ARG A CD  1 
ATOM   424  N NE  . ARG A 1 57  ? 19.32228  -13.87834 56.06820 1.000 80.25325  ? 65  ARG A NE  1 
ATOM   425  C CZ  . ARG A 1 57  ? 19.45990  -14.84045 56.97510 1.000 75.72676  ? 65  ARG A CZ  1 
ATOM   426  N NH1 . ARG A 1 57  ? 18.42288  -15.55050 57.38894 1.000 74.89106  ? 65  ARG A NH1 1 
ATOM   427  N NH2 . ARG A 1 57  ? 20.66332  -15.09766 57.47867 1.000 70.60534  ? 65  ARG A NH2 1 
ATOM   428  N N   . VAL A 1 58  ? 18.58998  -9.39077  51.60558 1.000 66.31917  ? 66  VAL A N   1 
ATOM   429  C CA  . VAL A 1 58  ? 19.08971  -9.53117  50.24303 1.000 66.99918  ? 66  VAL A CA  1 
ATOM   430  C C   . VAL A 1 58  ? 19.49019  -8.17101  49.68874 1.000 64.00399  ? 66  VAL A C   1 
ATOM   431  O O   . VAL A 1 58  ? 20.55325  -8.02873  49.07298 1.000 63.05827  ? 66  VAL A O   1 
ATOM   432  C CB  . VAL A 1 58  ? 18.05166  -10.21503 49.33364 1.000 67.69671  ? 66  VAL A CB  1 
ATOM   433  C CG1 . VAL A 1 58  ? 18.23679  -9.78623  47.89519 1.000 66.12085  ? 66  VAL A CG1 1 
ATOM   434  C CG2 . VAL A 1 58  ? 18.20790  -11.71028 49.42835 1.000 67.69661  ? 66  VAL A CG2 1 
ATOM   435  N N   . LEU A 1 59  ? 18.63177  -7.17063  49.87493 1.000 65.33868  ? 67  LEU A N   1 
ATOM   436  C CA  . LEU A 1 59  ? 18.93766  -5.84341  49.37669 1.000 63.45890  ? 67  LEU A CA  1 
ATOM   437  C C   . LEU A 1 59  ? 19.98792  -5.16126  50.24445 1.000 67.91050  ? 67  LEU A C   1 
ATOM   438  O O   . LEU A 1 59  ? 20.08171  -5.41783  51.44936 1.000 68.71514  ? 67  LEU A O   1 
ATOM   439  C CB  . LEU A 1 59  ? 17.69638  -4.96967  49.31083 1.000 62.84110  ? 67  LEU A CB  1 
ATOM   440  C CG  . LEU A 1 59  ? 16.85866  -5.12320  48.04193 1.000 67.30762  ? 67  LEU A CG  1 
ATOM   441  C CD1 . LEU A 1 59  ? 17.78090  -5.11144  46.83472 1.000 64.86113  ? 67  LEU A CD1 1 
ATOM   442  C CD2 . LEU A 1 59  ? 16.05936  -6.38257  48.05739 1.000 67.03821  ? 67  LEU A CD2 1 
ATOM   443  N N   . PRO A 1 60  ? 20.78560  -4.27538  49.65106 1.000 66.22776  ? 68  PRO A N   1 
ATOM   444  C CA  . PRO A 1 60  ? 21.68256  -3.45143  50.45607 1.000 66.54693  ? 68  PRO A CA  1 
ATOM   445  C C   . PRO A 1 60  ? 20.88978  -2.63260  51.45680 1.000 69.04291  ? 68  PRO A C   1 
ATOM   446  O O   . PRO A 1 60  ? 19.72365  -2.28462  51.23793 1.000 64.78318  ? 68  PRO A O   1 
ATOM   447  C CB  . PRO A 1 60  ? 22.38340  -2.56146  49.42184 1.000 68.99087  ? 68  PRO A CB  1 
ATOM   448  C CG  . PRO A 1 60  ? 21.47848  -2.58028  48.22512 1.000 68.56372  ? 68  PRO A CG  1 
ATOM   449  C CD  . PRO A 1 60  ? 20.86355  -3.94569  48.21909 1.000 65.81005  ? 68  PRO A CD  1 
ATOM   450  N N   . ALA A 1 61  ? 21.55683  -2.32249  52.56587 1.000 68.24117  ? 69  ALA A N   1 
ATOM   451  C CA  . ALA A 1 61  ? 20.89792  -1.63655  53.66294 1.000 66.11338  ? 69  ALA A CA  1 
ATOM   452  C C   . ALA A 1 61  ? 20.43517  -0.24547  53.24801 1.000 67.37342  ? 69  ALA A C   1 
ATOM   453  O O   . ALA A 1 61  ? 19.40930  0.24316   53.73445 1.000 65.54823  ? 69  ALA A O   1 
ATOM   454  C CB  . ALA A 1 61  ? 21.86229  -1.56870  54.84121 1.000 63.82541  ? 69  ALA A CB  1 
ATOM   455  N N   . GLU A 1 62  ? 21.17451  0.39448   52.33888 1.000 66.15163  ? 70  GLU A N   1 
ATOM   456  C CA  . GLU A 1 62  ? 20.80077  1.71403   51.84496 1.000 64.79401  ? 70  GLU A CA  1 
ATOM   457  C C   . GLU A 1 62  ? 19.48091  1.68516   51.07710 1.000 61.05218  ? 70  GLU A C   1 
ATOM   458  O O   . GLU A 1 62  ? 18.74626  2.68084   51.07635 1.000 61.25979  ? 70  GLU A O   1 
ATOM   459  C CB  . GLU A 1 62  ? 21.92239  2.29424   50.98465 1.000 62.24877  ? 70  GLU A CB  1 
ATOM   460  C CG  . GLU A 1 62  ? 23.32707  2.35770   51.62882 1.000 62.82570  ? 70  GLU A CG  1 
ATOM   461  C CD  . GLU A 1 62  ? 23.93017  1.00319   52.01351 1.000 66.67208  ? 70  GLU A CD  1 
ATOM   462  O OE1 . GLU A 1 62  ? 24.99164  0.99927   52.68170 1.000 70.20632  ? 70  GLU A OE1 1 
ATOM   463  O OE2 . GLU A 1 62  ? 23.37053  -0.05100  51.63624 1.000 66.88260  ? 70  GLU A OE2 1 
ATOM   464  N N   . VAL A 1 63  ? 19.17405  0.57639   50.40103 1.000 61.76387  ? 71  VAL A N   1 
ATOM   465  C CA  . VAL A 1 63  ? 17.91821  0.46142   49.65715 1.000 61.79976  ? 71  VAL A CA  1 
ATOM   466  C C   . VAL A 1 63  ? 16.75897  0.17802   50.59771 1.000 61.73610  ? 71  VAL A C   1 
ATOM   467  O O   . VAL A 1 63  ? 15.70940  0.82949   50.52776 1.000 59.12812  ? 71  VAL A O   1 
ATOM   468  C CB  . VAL A 1 63  ? 18.03431  -0.62345  48.57060 1.000 60.94225  ? 71  VAL A CB  1 
ATOM   469  C CG1 . VAL A 1 63  ? 16.66115  -0.99388  48.04212 1.000 55.11305  ? 71  VAL A CG1 1 
ATOM   470  C CG2 . VAL A 1 63  ? 18.92350  -0.13571  47.44106 1.000 59.16215  ? 71  VAL A CG2 1 
ATOM   471  N N   . LEU A 1 64  ? 16.93886  -0.80519  51.48274 1.000 61.09937  ? 72  LEU A N   1 
ATOM   472  C CA  . LEU A 1 64  ? 15.91861  -1.13398  52.46715 1.000 63.26821  ? 72  LEU A CA  1 
ATOM   473  C C   . LEU A 1 64  ? 15.56279  0.07339   53.31797 1.000 63.94859  ? 72  LEU A C   1 
ATOM   474  O O   . LEU A 1 64  ? 14.40612  0.21518   53.74053 1.000 65.27915  ? 72  LEU A O   1 
ATOM   475  C CB  . LEU A 1 64  ? 16.40491  -2.27217  53.36032 1.000 64.87327  ? 72  LEU A CB  1 
ATOM   476  C CG  . LEU A 1 64  ? 16.67145  -3.62508  52.70568 1.000 65.20511  ? 72  LEU A CG  1 
ATOM   477  C CD1 . LEU A 1 64  ? 17.77938  -4.32623  53.45039 1.000 66.61344  ? 72  LEU A CD1 1 
ATOM   478  C CD2 . LEU A 1 64  ? 15.41612  -4.45984  52.72959 1.000 66.77842  ? 72  LEU A CD2 1 
ATOM   479  N N   . ALA A 1 65  ? 16.53403  0.95466   53.56905 1.000 61.51346  ? 73  ALA A N   1 
ATOM   480  C CA  . ALA A 1 65  ? 16.24455  2.22510   54.22670 1.000 63.29465  ? 73  ALA A CA  1 
ATOM   481  C C   . ALA A 1 65  ? 15.09165  2.94902   53.53730 1.000 63.59028  ? 73  ALA A C   1 
ATOM   482  O O   . ALA A 1 65  ? 14.01909  3.13158   54.12017 1.000 69.41266  ? 73  ALA A O   1 
ATOM   483  C CB  . ALA A 1 65  ? 17.49949  3.09640   54.24843 1.000 63.34681  ? 73  ALA A CB  1 
ATOM   484  N N   . GLN A 1 66  ? 15.27093  3.30604   52.26801 1.000 62.85184  ? 74  GLN A N   1 
ATOM   485  C CA  . GLN A 1 66  ? 14.26912  4.05121   51.50953 1.000 63.68828  ? 74  GLN A CA  1 
ATOM   486  C C   . GLN A 1 66  ? 13.08844  3.19861   51.03644 1.000 61.02671  ? 74  GLN A C   1 
ATOM   487  O O   . GLN A 1 66  ? 12.43917  3.59955   50.06780 1.000 60.24368  ? 74  GLN A O   1 
ATOM   488  C CB  . GLN A 1 66  ? 14.91164  4.71130   50.28689 1.000 65.80058  ? 74  GLN A CB  1 
ATOM   489  C CG  . GLN A 1 66  ? 16.00525  5.71261   50.57452 1.000 63.62068  ? 74  GLN A CG  1 
ATOM   490  C CD  . GLN A 1 66  ? 15.43877  7.02949   51.02608 1.000 69.75218  ? 74  GLN A CD  1 
ATOM   491  O OE1 . GLN A 1 66  ? 14.75223  7.71773   50.26703 1.000 71.35487  ? 74  GLN A OE1 1 
ATOM   492  N NE2 . GLN A 1 66  ? 15.72028  7.39518   52.26808 1.000 74.72836  ? 74  GLN A NE2 1 
ATOM   493  N N   . TRP A 1 67  ? 12.78632  2.05658   51.66534 1.000 60.24056  ? 75  TRP A N   1 
ATOM   494  C CA  . TRP A 1 67  ? 11.80152  1.14182   51.08563 1.000 59.42375  ? 75  TRP A CA  1 
ATOM   495  C C   . TRP A 1 67  ? 10.39597  1.72973   51.04813 1.000 62.20795  ? 75  TRP A C   1 
ATOM   496  O O   . TRP A 1 67  ? 9.60551   1.37537   50.16455 1.000 60.51454  ? 75  TRP A O   1 
ATOM   497  C CB  . TRP A 1 67  ? 11.75926  -0.16968  51.86391 1.000 58.19362  ? 75  TRP A CB  1 
ATOM   498  C CG  . TRP A 1 67  ? 10.88487  -1.18908  51.19718 1.000 62.34906  ? 75  TRP A CG  1 
ATOM   499  C CD1 . TRP A 1 67  ? 9.59796   -1.50771  51.52492 1.000 62.71124  ? 75  TRP A CD1 1 
ATOM   500  C CD2 . TRP A 1 67  ? 11.23417  -2.03024  50.08531 1.000 64.01490  ? 75  TRP A CD2 1 
ATOM   501  N NE1 . TRP A 1 67  ? 9.12487   -2.48868  50.68707 1.000 61.09092  ? 75  TRP A NE1 1 
ATOM   502  C CE2 . TRP A 1 67  ? 10.10726  -2.82585  49.79446 1.000 60.05072  ? 75  TRP A CE2 1 
ATOM   503  C CE3 . TRP A 1 67  ? 12.39282  -2.18888  49.31081 1.000 63.22159  ? 75  TRP A CE3 1 
ATOM   504  C CZ2 . TRP A 1 67  ? 10.10154  -3.76201  48.76624 1.000 61.32092  ? 75  TRP A CZ2 1 
ATOM   505  C CZ3 . TRP A 1 67  ? 12.38452  -3.11923  48.28558 1.000 59.85495  ? 75  TRP A CZ3 1 
ATOM   506  C CH2 . TRP A 1 67  ? 11.24673  -3.89087  48.02238 1.000 63.34162  ? 75  TRP A CH2 1 
ATOM   507  N N   . GLU A 1 68  ? 10.05391  2.61294   51.99848 1.000 63.45605  ? 76  GLU A N   1 
ATOM   508  C CA  . GLU A 1 68  ? 8.69796   3.16624   52.01445 1.000 66.62901  ? 76  GLU A CA  1 
ATOM   509  C C   . GLU A 1 68  ? 8.44260   4.09405   50.83172 1.000 62.73155  ? 76  GLU A C   1 
ATOM   510  O O   . GLU A 1 68  ? 7.50395   3.83496   50.05585 1.000 59.74997  ? 76  GLU A O   1 
ATOM   511  C CB  . GLU A 1 68  ? 8.41915   3.83720   53.36318 1.000 72.98172  ? 76  GLU A CB  1 
ATOM   512  C CG  . GLU A 1 68  ? 7.78378   2.90655   54.38603 1.000 75.84805  ? 76  GLU A CG  1 
ATOM   513  C CD  . GLU A 1 68  ? 6.29247   2.72659   54.15811 1.000 83.91641  ? 76  GLU A CD  1 
ATOM   514  O OE1 . GLU A 1 68  ? 5.74322   3.36666   53.22599 1.000 82.23354  ? 76  GLU A OE1 1 
ATOM   515  O OE2 . GLU A 1 68  ? 5.67400   1.93299   54.90536 1.000 88.94750  ? 76  GLU A OE2 1 
ATOM   516  N N   . PRO A 1 69  ? 9.21992   5.16426   50.61463 1.000 63.43306  ? 77  PRO A N   1 
ATOM   517  C CA  . PRO A 1 69  ? 8.99129   5.98115   49.41300 1.000 62.42015  ? 77  PRO A CA  1 
ATOM   518  C C   . PRO A 1 69  ? 9.25066   5.22712   48.12821 1.000 62.12291  ? 77  PRO A C   1 
ATOM   519  O O   . PRO A 1 69  ? 8.73346   5.62535   47.07532 1.000 59.83172  ? 77  PRO A O   1 
ATOM   520  C CB  . PRO A 1 69  ? 9.97698   7.14222   49.58287 1.000 61.40921  ? 77  PRO A CB  1 
ATOM   521  C CG  . PRO A 1 69  ? 11.05729  6.57904   50.39626 1.000 62.19728  ? 77  PRO A CG  1 
ATOM   522  C CD  . PRO A 1 69  ? 10.39471  5.64522   51.36269 1.000 62.47478  ? 77  PRO A CD  1 
ATOM   523  N N   . LEU A 1 70  ? 10.04331  4.15396   48.17804 1.000 58.77878  ? 78  LEU A N   1 
ATOM   524  C CA  . LEU A 1 70  ? 10.26172  3.36081   46.97978 1.000 56.08567  ? 78  LEU A CA  1 
ATOM   525  C C   . LEU A 1 70  ? 8.97981   2.68701   46.54534 1.000 56.41100  ? 78  LEU A C   1 
ATOM   526  O O   . LEU A 1 70  ? 8.65928   2.67308   45.35272 1.000 57.30102  ? 78  LEU A O   1 
ATOM   527  C CB  . LEU A 1 70  ? 11.35692  2.32503   47.21175 1.000 55.28625  ? 78  LEU A CB  1 
ATOM   528  C CG  . LEU A 1 70  ? 11.58316  1.37482   46.03944 1.000 53.93540  ? 78  LEU A CG  1 
ATOM   529  C CD1 . LEU A 1 70  ? 11.91010  2.13920   44.77321 1.000 50.97978  ? 78  LEU A CD1 1 
ATOM   530  C CD2 . LEU A 1 70  ? 12.68111  0.39570   46.38280 1.000 53.76208  ? 78  LEU A CD2 1 
ATOM   531  N N   . VAL A 1 71  ? 8.23650   2.11711   47.49956 1.000 59.51256  ? 79  VAL A N   1 
ATOM   532  C CA  . VAL A 1 71  ? 6.92383   1.56302   47.18088 1.000 58.79430  ? 79  VAL A CA  1 
ATOM   533  C C   . VAL A 1 71  ? 5.93605   2.67569   46.83535 1.000 58.03870  ? 79  VAL A C   1 
ATOM   534  O O   . VAL A 1 71  ? 5.19744   2.57887   45.84748 1.000 57.57960  ? 79  VAL A O   1 
ATOM   535  C CB  . VAL A 1 71  ? 6.41368   0.69103   48.34323 1.000 56.84223  ? 79  VAL A CB  1 
ATOM   536  C CG1 . VAL A 1 71  ? 5.05829   0.06950   47.98840 1.000 53.63849  ? 79  VAL A CG1 1 
ATOM   537  C CG2 . VAL A 1 71  ? 7.43020   -0.40397  48.67740 1.000 58.30402  ? 79  VAL A CG2 1 
ATOM   538  N N   . ALA A 1 72  ? 5.95310   3.77274   47.59750 1.000 56.48373  ? 80  ALA A N   1 
ATOM   539  C CA  . ALA A 1 72  ? 4.98262   4.83922   47.39154 1.000 55.73741  ? 80  ALA A CA  1 
ATOM   540  C C   . ALA A 1 72  ? 5.11655   5.43525   45.99628 1.000 60.74153  ? 80  ALA A C   1 
ATOM   541  O O   . ALA A 1 72  ? 4.15382   5.45087   45.21885 1.000 62.75712  ? 80  ALA A O   1 
ATOM   542  C CB  . ALA A 1 72  ? 5.15293   5.90978   48.46894 1.000 55.07923  ? 80  ALA A CB  1 
ATOM   543  N N   . ARG A 1 73  ? 6.31550   5.90575   45.64684 1.000 58.65286  ? 81  ARG A N   1 
ATOM   544  C CA  . ARG A 1 73  ? 6.52417   6.62189   44.39380 1.000 59.16189  ? 81  ARG A CA  1 
ATOM   545  C C   . ARG A 1 73  ? 7.01144   5.73648   43.24543 1.000 57.36374  ? 81  ARG A C   1 
ATOM   546  O O   . ARG A 1 73  ? 6.98893   6.18334   42.09249 1.000 57.10297  ? 81  ARG A O   1 
ATOM   547  C CB  . ARG A 1 73  ? 7.51189   7.78761   44.61430 1.000 58.65876  ? 81  ARG A CB  1 
ATOM   548  C CG  . ARG A 1 73  ? 7.23406   8.60778   45.88258 1.000 62.99702  ? 81  ARG A CG  1 
ATOM   549  C CD  . ARG A 1 73  ? 8.32382   9.63442   46.17363 1.000 71.53308  ? 81  ARG A CD  1 
ATOM   550  N NE  . ARG A 1 73  ? 8.06285   10.95082  45.59440 1.000 83.21248  ? 81  ARG A NE  1 
ATOM   551  C CZ  . ARG A 1 73  ? 7.70003   12.02494  46.28918 1.000 85.77317  ? 81  ARG A CZ  1 
ATOM   552  N NH1 . ARG A 1 73  ? 7.52673   11.97589  47.60190 1.000 83.18948  ? 81  ARG A NH1 1 
ATOM   553  N NH2 . ARG A 1 73  ? 7.51449   13.18035  45.65215 1.000 83.79128  ? 81  ARG A NH2 1 
ATOM   554  N N   . GLY A 1 74  ? 7.42502   4.49399   43.51312 1.000 55.56588  ? 82  GLY A N   1 
ATOM   555  C CA  . GLY A 1 74  ? 7.94013   3.62936   42.46803 1.000 53.09909  ? 82  GLY A CA  1 
ATOM   556  C C   . GLY A 1 74  ? 9.39658   3.84089   42.10217 1.000 54.95036  ? 82  GLY A C   1 
ATOM   557  O O   . GLY A 1 74  ? 9.94939   3.04539   41.32913 1.000 52.54843  ? 82  GLY A O   1 
ATOM   558  N N   . SER A 1 75  ? 10.03209  4.89506   42.60230 1.000 55.89022  ? 83  SER A N   1 
ATOM   559  C CA  . SER A 1 75  ? 11.44242  5.11686   42.35045 1.000 52.99019  ? 83  SER A CA  1 
ATOM   560  C C   . SER A 1 75  ? 12.03632  5.84852   43.54432 1.000 56.10170  ? 83  SER A C   1 
ATOM   561  O O   . SER A 1 75  ? 11.31971  6.53430   44.28289 1.000 56.99770  ? 83  SER A O   1 
ATOM   562  C CB  . SER A 1 75  ? 11.67388  5.91231   41.06233 1.000 53.76326  ? 83  SER A CB  1 
ATOM   563  O OG  . SER A 1 75  ? 11.90381  7.28045   41.34639 1.000 62.47086  ? 83  SER A OG  1 
ATOM   564  N N   . VAL A 1 76  ? 13.34315  5.66794   43.74023 1.000 52.09913  ? 84  VAL A N   1 
ATOM   565  C CA  . VAL A 1 76  ? 14.08771  6.35705   44.79595 1.000 56.92400  ? 84  VAL A CA  1 
ATOM   566  C C   . VAL A 1 76  ? 15.57363  6.33792   44.42942 1.000 53.29718  ? 84  VAL A C   1 
ATOM   567  O O   . VAL A 1 76  ? 16.06733  5.37132   43.84410 1.000 51.40511  ? 84  VAL A O   1 
ATOM   568  C CB  . VAL A 1 76  ? 13.81926  5.70887   46.17784 1.000 57.63235  ? 84  VAL A CB  1 
ATOM   569  C CG1 . VAL A 1 76  ? 14.37114  4.30386   46.23233 1.000 53.95821  ? 84  VAL A CG1 1 
ATOM   570  C CG2 . VAL A 1 76  ? 14.39427  6.55623   47.30157 1.000 60.29257  ? 84  VAL A CG2 1 
ATOM   571  N N   . ARG A 1 77  ? 16.27647  7.42947   44.73978 1.000 51.10600  ? 85  ARG A N   1 
ATOM   572  C CA  . ARG A 1 77  ? 17.72933  7.47246   44.58804 1.000 56.19604  ? 85  ARG A CA  1 
ATOM   573  C C   . ARG A 1 77  ? 18.36832  6.99153   45.88059 1.000 57.59131  ? 85  ARG A C   1 
ATOM   574  O O   . ARG A 1 77  ? 17.89501  7.31827   46.97152 1.000 58.21466  ? 85  ARG A O   1 
ATOM   575  C CB  . ARG A 1 77  ? 18.22970  8.88444   44.28038 1.000 53.19935  ? 85  ARG A CB  1 
ATOM   576  C CG  . ARG A 1 77  ? 17.43811  9.64345   43.22531 1.000 55.39811  ? 85  ARG A CG  1 
ATOM   577  C CD  . ARG A 1 77  ? 17.23493  8.86705   41.93971 1.000 56.79936  ? 85  ARG A CD  1 
ATOM   578  N NE  . ARG A 1 77  ? 16.01664  9.28236   41.24308 1.000 63.16519  ? 85  ARG A NE  1 
ATOM   579  C CZ  . ARG A 1 77  ? 14.85980  8.62235   41.25602 1.000 62.47553  ? 85  ARG A CZ  1 
ATOM   580  N NH1 . ARG A 1 77  ? 14.72300  7.46897   41.88198 1.000 62.84360  ? 85  ARG A NH1 1 
ATOM   581  N NH2 . ARG A 1 77  ? 13.81058  9.13210   40.62003 1.000 63.76659  ? 85  ARG A NH2 1 
ATOM   582  N N   . VAL A 1 78  ? 19.43415  6.19895   45.76010 1.000 54.32777  ? 86  VAL A N   1 
ATOM   583  C CA  . VAL A 1 78  ? 20.13958  5.68044   46.92507 1.000 51.72647  ? 86  VAL A CA  1 
ATOM   584  C C   . VAL A 1 78  ? 21.63823  5.73716   46.66137 1.000 55.82557  ? 86  VAL A C   1 
ATOM   585  O O   . VAL A 1 78  ? 22.09193  5.67081   45.51530 1.000 55.00168  ? 86  VAL A O   1 
ATOM   586  C CB  . VAL A 1 78  ? 19.69819  4.24099   47.29835 1.000 53.31300  ? 86  VAL A CB  1 
ATOM   587  C CG1 . VAL A 1 78  ? 18.19852  4.17851   47.59297 1.000 54.90620  ? 86  VAL A CG1 1 
ATOM   588  C CG2 . VAL A 1 78  ? 20.05844  3.25059   46.20138 1.000 53.05968  ? 86  VAL A CG2 1 
ATOM   589  N N   . VAL A 1 79  ? 22.41200  5.86092   47.73316 1.000 55.46053  ? 87  VAL A N   1 
ATOM   590  C CA  . VAL A 1 79  ? 23.86562  5.91482   47.64465 1.000 54.92279  ? 87  VAL A CA  1 
ATOM   591  C C   . VAL A 1 79  ? 24.40380  4.63821   48.27181 1.000 54.34718  ? 87  VAL A C   1 
ATOM   592  O O   . VAL A 1 79  ? 24.29770  4.44094   49.48784 1.000 56.37268  ? 87  VAL A O   1 
ATOM   593  C CB  . VAL A 1 79  ? 24.43979  7.16553   48.32251 1.000 52.52367  ? 87  VAL A CB  1 
ATOM   594  C CG1 . VAL A 1 79  ? 25.93538  7.24205   48.08632 1.000 57.79601  ? 87  VAL A CG1 1 
ATOM   595  C CG2 . VAL A 1 79  ? 23.77830  8.39854   47.77789 1.000 50.91755  ? 87  VAL A CG2 1 
ATOM   596  N N   . LEU A 1 80  ? 24.92418  3.73969   47.42894 1.000 54.87642  ? 88  LEU A N   1 
ATOM   597  C CA  . LEU A 1 80  ? 25.55798  2.49805   47.84485 1.000 54.41223  ? 88  LEU A CA  1 
ATOM   598  C C   . LEU A 1 80  ? 27.05765  2.69507   47.95574 1.000 52.13186  ? 88  LEU A C   1 
ATOM   599  O O   . LEU A 1 80  ? 27.60620  3.64289   47.38913 1.000 53.82058  ? 88  LEU A O   1 
ATOM   600  C CB  . LEU A 1 80  ? 25.25241  1.39006   46.83667 1.000 52.00821  ? 88  LEU A CB  1 
ATOM   601  C CG  . LEU A 1 80  ? 23.76869  1.21643   46.51319 1.000 54.74480  ? 88  LEU A CG  1 
ATOM   602  C CD1 . LEU A 1 80  ? 23.59762  0.19937   45.40479 1.000 56.65708  ? 88  LEU A CD1 1 
ATOM   603  C CD2 . LEU A 1 80  ? 22.99874  0.79865   47.75771 1.000 55.32825  ? 88  LEU A CD2 1 
ATOM   604  N N   . PRO A 1 81  ? 27.76743  1.81880   48.67109 1.000 54.17984  ? 89  PRO A N   1 
ATOM   605  C CA  . PRO A 1 81  ? 29.23468  1.86780   48.58188 1.000 53.91442  ? 89  PRO A CA  1 
ATOM   606  C C   . PRO A 1 81  ? 29.72756  1.87739   47.14551 1.000 52.90511  ? 89  PRO A C   1 
ATOM   607  O O   . PRO A 1 81  ? 30.70371  2.57923   46.84531 1.000 57.65425  ? 89  PRO A O   1 
ATOM   608  C CB  . PRO A 1 81  ? 29.68838  0.61602   49.35475 1.000 52.38465  ? 89  PRO A CB  1 
ATOM   609  C CG  . PRO A 1 81  ? 28.44281  -0.16496  49.68038 1.000 54.43865  ? 89  PRO A CG  1 
ATOM   610  C CD  . PRO A 1 81  ? 27.31705  0.83834   49.67242 1.000 54.63708  ? 89  PRO A CD  1 
ATOM   611  N N   . ALA A 1 82  ? 29.03569  1.18662   46.23193 1.000 51.14248  ? 90  ALA A N   1 
ATOM   612  C CA  . ALA A 1 82  ? 29.43458  1.14386   44.82566 1.000 53.50067  ? 90  ALA A CA  1 
ATOM   613  C C   . ALA A 1 82  ? 29.18838  2.45017   44.07928 1.000 49.83757  ? 90  ALA A C   1 
ATOM   614  O O   . ALA A 1 82  ? 29.71340  2.60954   42.97153 1.000 50.78092  ? 90  ALA A O   1 
ATOM   615  C CB  . ALA A 1 82  ? 28.71248  0.00737   44.10191 1.000 51.06106  ? 90  ALA A CB  1 
ATOM   616  N N   . GLY A 1 83  ? 28.44310  3.38771   44.65484 1.000 50.48847  ? 91  GLY A N   1 
ATOM   617  C CA  . GLY A 1 83  ? 28.11209  4.64754   44.02466 1.000 48.88540  ? 91  GLY A CA  1 
ATOM   618  C C   . GLY A 1 83  ? 26.62401  4.91386   44.05973 1.000 49.99301  ? 91  GLY A C   1 
ATOM   619  O O   . GLY A 1 83  ? 25.85111  4.21267   44.72558 1.000 50.48073  ? 91  GLY A O   1 
ATOM   620  N N   . ALA A 1 84  ? 26.21457  5.96012   43.34352 1.000 50.10923  ? 92  ALA A N   1 
ATOM   621  C CA  . ALA A 1 84  ? 24.81304  6.35874   43.30800 1.000 52.75410  ? 92  ALA A CA  1 
ATOM   622  C C   . ALA A 1 84  ? 24.00420  5.42336   42.41574 1.000 51.21795  ? 92  ALA A C   1 
ATOM   623  O O   . ALA A 1 84  ? 24.44307  5.04291   41.32474 1.000 50.99989  ? 92  ALA A O   1 
ATOM   624  C CB  . ALA A 1 84  ? 24.68187  7.80109   42.81164 1.000 51.12972  ? 92  ALA A CB  1 
ATOM   625  N N   . TYR A 1 85  ? 22.80120  5.08195   42.86753 1.000 48.10662  ? 93  TYR A N   1 
ATOM   626  C CA  . TYR A 1 85  ? 21.92669  4.17899   42.13144 1.000 49.87992  ? 93  TYR A CA  1 
ATOM   627  C C   . TYR A 1 85  ? 20.49723  4.70613   42.14084 1.000 53.82563  ? 93  TYR A C   1 
ATOM   628  O O   . TYR A 1 85  ? 20.09209  5.46161   43.03343 1.000 54.61843  ? 93  TYR A O   1 
ATOM   629  C CB  . TYR A 1 85  ? 21.97405  2.75527   42.71229 1.000 51.51160  ? 93  TYR A CB  1 
ATOM   630  C CG  . TYR A 1 85  ? 23.00591  1.88592   42.03157 1.000 49.14267  ? 93  TYR A CG  1 
ATOM   631  C CD1 . TYR A 1 85  ? 24.34612  1.98123   42.36229 1.000 47.66560  ? 93  TYR A CD1 1 
ATOM   632  C CD2 . TYR A 1 85  ? 22.63290  0.98670   41.03816 1.000 48.48405  ? 93  TYR A CD2 1 
ATOM   633  C CE1 . TYR A 1 85  ? 25.30038  1.20513   41.71462 1.000 49.16574  ? 93  TYR A CE1 1 
ATOM   634  C CE2 . TYR A 1 85  ? 23.55893  0.19771   40.39622 1.000 47.06918  ? 93  TYR A CE2 1 
ATOM   635  C CZ  . TYR A 1 85  ? 24.89863  0.30946   40.73686 1.000 51.33348  ? 93  TYR A CZ  1 
ATOM   636  O OH  . TYR A 1 85  ? 25.83114  -0.47020  40.09160 1.000 48.44925  ? 93  TYR A OH  1 
ATOM   637  N N   . ARG A 1 86  ? 19.75508  4.33013   41.10486 1.000 51.13044  ? 94  ARG A N   1 
ATOM   638  C CA  . ARG A 1 86  ? 18.31383  4.52121   41.01748 1.000 50.93580  ? 94  ARG A CA  1 
ATOM   639  C C   . ARG A 1 86  ? 17.61694  3.17966   41.20020 1.000 47.83943  ? 94  ARG A C   1 
ATOM   640  O O   . ARG A 1 86  ? 17.95945  2.20764   40.52166 1.000 44.74799  ? 94  ARG A O   1 
ATOM   641  C CB  . ARG A 1 86  ? 17.94795  5.14387   39.66679 1.000 52.33434  ? 94  ARG A CB  1 
ATOM   642  C CG  . ARG A 1 86  ? 16.85566  6.18467   39.72893 1.000 56.59798  ? 94  ARG A CG  1 
ATOM   643  C CD  . ARG A 1 86  ? 17.20676  7.44126   38.90099 1.000 65.63851  ? 94  ARG A CD  1 
ATOM   644  N NE  . ARG A 1 86  ? 17.66848  7.20120   37.53123 1.000 65.22334  ? 94  ARG A NE  1 
ATOM   645  C CZ  . ARG A 1 86  ? 18.70568  7.81077   36.96774 1.000 60.10686  ? 94  ARG A CZ  1 
ATOM   646  N NH1 . ARG A 1 86  ? 19.44601  8.68926   37.63841 1.000 55.35948  ? 94  ARG A NH1 1 
ATOM   647  N NH2 . ARG A 1 86  ? 18.98716  7.55685   35.69159 1.000 59.48569  ? 94  ARG A NH2 1 
ATOM   648  N N   . ALA A 1 87  ? 16.65170  3.12418   42.11652 1.000 49.20018  ? 95  ALA A N   1 
ATOM   649  C CA  . ALA A 1 87  ? 15.80982  1.95063   42.30957 1.000 45.36325  ? 95  ALA A CA  1 
ATOM   650  C C   . ALA A 1 87  ? 14.41278  2.21848   41.76903 1.000 49.37619  ? 95  ALA A C   1 
ATOM   651  O O   . ALA A 1 87  ? 13.84363  3.28911   41.98383 1.000 50.29813  ? 95  ALA A O   1 
ATOM   652  C CB  . ALA A 1 87  ? 15.72636  1.53868   43.78183 1.000 46.96225  ? 95  ALA A CB  1 
ATOM   653  N N   . LEU A 1 88  ? 13.87822  1.22701   41.07141 1.000 46.28511  ? 96  LEU A N   1 
ATOM   654  C CA  . LEU A 1 88  ? 12.66150  1.31639   40.29312 1.000 43.96388  ? 96  LEU A CA  1 
ATOM   655  C C   . LEU A 1 88  ? 11.85767  0.06380   40.58461 1.000 47.74644  ? 96  LEU A C   1 
ATOM   656  O O   . LEU A 1 88  ? 12.39193  -1.04271  40.47618 1.000 47.19434  ? 96  LEU A O   1 
ATOM   657  C CB  . LEU A 1 88  ? 12.99716  1.39870   38.80044 1.000 47.76916  ? 96  LEU A CB  1 
ATOM   658  C CG  . LEU A 1 88  ? 13.93601  2.53811   38.37429 1.000 52.59618  ? 96  LEU A CG  1 
ATOM   659  C CD1 . LEU A 1 88  ? 14.28973  2.46511   36.90036 1.000 44.24690  ? 96  LEU A CD1 1 
ATOM   660  C CD2 . LEU A 1 88  ? 13.27474  3.88829   38.66706 1.000 52.65203  ? 96  LEU A CD2 1 
ATOM   661  N N   . LEU A 1 89  ? 10.58755  0.23449   40.95611 1.000 50.35549  ? 97  LEU A N   1 
ATOM   662  C CA  . LEU A 1 89  ? 9.70719   -0.86308  41.35472 1.000 46.61024  ? 97  LEU A CA  1 
ATOM   663  C C   . LEU A 1 89  ? 8.48412   -0.89828  40.44934 1.000 48.57240  ? 97  LEU A C   1 
ATOM   664  O O   . LEU A 1 89  ? 7.82840   0.12534   40.25863 1.000 49.33954  ? 97  LEU A O   1 
ATOM   665  C CB  . LEU A 1 89  ? 9.23660   -0.68775  42.79468 1.000 47.52347  ? 97  LEU A CB  1 
ATOM   666  C CG  . LEU A 1 89  ? 9.68621   -1.61646  43.90724 1.000 52.93101  ? 97  LEU A CG  1 
ATOM   667  C CD1 . LEU A 1 89  ? 11.19069  -1.60146  44.01339 1.000 57.54468  ? 97  LEU A CD1 1 
ATOM   668  C CD2 . LEU A 1 89  ? 9.06683   -1.16176  45.20963 1.000 55.37532  ? 97  LEU A CD2 1 
ATOM   669  N N   . HIS A 1 90  ? 8.14777   -2.07266  39.92875 1.000 48.14941  ? 98  HIS A N   1 
ATOM   670  C CA  . HIS A 1 90  ? 6.86895   -2.23766  39.25229 1.000 47.72064  ? 98  HIS A CA  1 
ATOM   671  C C   . HIS A 1 90  ? 6.37344   -3.65733  39.49034 1.000 47.83666  ? 98  HIS A C   1 
ATOM   672  O O   . HIS A 1 90  ? 7.06915   -4.49122  40.08134 1.000 46.59232  ? 98  HIS A O   1 
ATOM   673  C CB  . HIS A 1 90  ? 6.96818   -1.90233  37.75415 1.000 45.93128  ? 98  HIS A CB  1 
ATOM   674  C CG  . HIS A 1 90  ? 7.65014   -2.94772  36.92113 1.000 47.07265  ? 98  HIS A CG  1 
ATOM   675  N ND1 . HIS A 1 90  ? 9.02220   -3.05714  36.83383 1.000 42.75096  ? 98  HIS A ND1 1 
ATOM   676  C CD2 . HIS A 1 90  ? 7.14617   -3.88038  36.07634 1.000 47.41485  ? 98  HIS A CD2 1 
ATOM   677  C CE1 . HIS A 1 90  ? 9.33255   -4.03672  36.00454 1.000 42.78185  ? 98  HIS A CE1 1 
ATOM   678  N NE2 . HIS A 1 90  ? 8.21348   -4.54667  35.52257 1.000 42.51173  ? 98  HIS A NE2 1 
ATOM   679  N N   . GLU A 1 91  ? 5.14188   -3.91485  39.05798 1.000 47.10042  ? 99  GLU A N   1 
ATOM   680  C CA  . GLU A 1 91  ? 4.51825   -5.22170  39.22514 1.000 53.17335  ? 99  GLU A CA  1 
ATOM   681  C C   . GLU A 1 91  ? 4.44159   -5.94320  37.89124 1.000 50.15166  ? 99  GLU A C   1 
ATOM   682  O O   . GLU A 1 91  ? 4.16756   -5.32598  36.86100 1.000 54.29331  ? 99  GLU A O   1 
ATOM   683  C CB  . GLU A 1 91  ? 3.10960   -5.09990  39.80978 1.000 54.63031  ? 99  GLU A CB  1 
ATOM   684  C CG  . GLU A 1 91  ? 3.05974   -4.45579  41.17265 1.000 60.16179  ? 99  GLU A CG  1 
ATOM   685  C CD  . GLU A 1 91  ? 3.43721   -5.43720  42.27844 1.000 66.84941  ? 99  GLU A CD  1 
ATOM   686  O OE1 . GLU A 1 91  ? 4.13361   -5.00756  43.23733 1.000 63.40653  ? 99  GLU A OE1 1 
ATOM   687  O OE2 . GLU A 1 91  ? 3.02942   -6.63265  42.18373 1.000 67.08053  ? 99  GLU A OE2 1 
ATOM   688  N N   . SER A 1 92  ? 4.66717   -7.25327  37.92190 1.000 47.65753  ? 100 SER A N   1 
ATOM   689  C CA  . SER A 1 92  ? 4.63296   -8.06243  36.71100 1.000 52.14901  ? 100 SER A CA  1 
ATOM   690  C C   . SER A 1 92  ? 4.48206   -9.52307  37.10691 1.000 49.60000  ? 100 SER A C   1 
ATOM   691  O O   . SER A 1 92  ? 5.15471   -9.98485  38.03168 1.000 47.83587  ? 100 SER A O   1 
ATOM   692  C CB  . SER A 1 92  ? 5.90553   -7.87091  35.86639 1.000 48.37380  ? 100 SER A CB  1 
ATOM   693  O OG  . SER A 1 92  ? 5.85309   -8.62554  34.65935 1.000 44.46617  ? 100 SER A OG  1 
ATOM   694  N N   . ASP A 1 93  ? 3.58653   -10.23226 36.41744 1.000 52.17526  ? 101 ASP A N   1 
ATOM   695  C CA  . ASP A 1 93  ? 3.35401   -11.66519 36.63563 1.000 49.72976  ? 101 ASP A CA  1 
ATOM   696  C C   . ASP A 1 93  ? 3.05124   -11.97232 38.10535 1.000 49.44749  ? 101 ASP A C   1 
ATOM   697  O O   . ASP A 1 93  ? 3.34465   -13.06692 38.59782 1.000 49.72556  ? 101 ASP A O   1 
ATOM   698  C CB  . ASP A 1 93  ? 4.53823   -12.51104 36.14949 1.000 48.45652  ? 101 ASP A CB  1 
ATOM   699  C CG  . ASP A 1 93  ? 4.60453   -12.65332 34.61710 1.000 48.65833  ? 101 ASP A CG  1 
ATOM   700  O OD1 . ASP A 1 93  ? 3.55159   -12.73465 33.94779 1.000 48.62252  ? 101 ASP A OD1 1 
ATOM   701  O OD2 . ASP A 1 93  ? 5.73472   -12.76128 34.07560 1.000 49.25197  ? 101 ASP A OD2 1 
ATOM   702  N N   . GLY A 1 94  ? 2.49282   -10.99677 38.82739 1.000 47.38492  ? 102 GLY A N   1 
ATOM   703  C CA  . GLY A 1 94  ? 2.26187   -11.12787 40.25256 1.000 49.86853  ? 102 GLY A CA  1 
ATOM   704  C C   . GLY A 1 94  ? 3.48667   -10.90851 41.10507 1.000 55.67455  ? 102 GLY A C   1 
ATOM   705  O O   . GLY A 1 94  ? 3.37303   -10.84001 42.33837 1.000 58.08556  ? 102 GLY A O   1 
ATOM   706  N N   . LEU A 1 95  ? 4.65175   -10.78702 40.49168 1.000 56.73821  ? 103 LEU A N   1 
ATOM   707  C CA  . LEU A 1 95  ? 5.87628   -10.48819 41.20134 1.000 54.03963  ? 103 LEU A CA  1 
ATOM   708  C C   . LEU A 1 95  ? 6.07882   -8.98370  41.26970 1.000 55.03867  ? 103 LEU A C   1 
ATOM   709  O O   . LEU A 1 95  ? 5.67379   -8.23300  40.37450 1.000 55.70089  ? 103 LEU A O   1 
ATOM   710  C CB  . LEU A 1 95  ? 7.04819   -11.16077 40.49638 1.000 53.67343  ? 103 LEU A CB  1 
ATOM   711  C CG  . LEU A 1 95  ? 6.95016   -12.68678 40.49216 1.000 55.94807  ? 103 LEU A CG  1 
ATOM   712  C CD1 . LEU A 1 95  ? 7.67388   -13.29556 39.31188 1.000 52.29227  ? 103 LEU A CD1 1 
ATOM   713  C CD2 . LEU A 1 95  ? 7.53154   -13.21777 41.78194 1.000 61.69639  ? 103 LEU A CD2 1 
ATOM   714  N N   . THR A 1 96  ? 6.70407   -8.54213  42.34412 1.000 51.61630  ? 104 THR A N   1 
ATOM   715  C CA  . THR A 1 96  ? 7.16792   -7.17168  42.43115 1.000 53.93165  ? 104 THR A CA  1 
ATOM   716  C C   . THR A 1 96  ? 8.63709   -7.15130  42.00663 1.000 56.02343  ? 104 THR A C   1 
ATOM   717  O O   . THR A 1 96  ? 9.47829   -7.84008  42.60059 1.000 50.21131  ? 104 THR A O   1 
ATOM   718  C CB  . THR A 1 96  ? 6.95732   -6.62450  43.83829 1.000 53.33070  ? 104 THR A CB  1 
ATOM   719  O OG1 . THR A 1 96  ? 8.09745   -6.91523  44.63563 1.000 62.23389  ? 104 THR A OG1 1 
ATOM   720  C CG2 . THR A 1 96  ? 5.75956   -7.29268  44.46590 1.000 56.05674  ? 104 THR A CG2 1 
ATOM   721  N N   . VAL A 1 97  ? 8.92474   -6.37967  40.96094 1.000 53.21024  ? 105 VAL A N   1 
ATOM   722  C CA  . VAL A 1 97  ? 10.21379  -6.37775  40.28767 1.000 46.80625  ? 105 VAL A CA  1 
ATOM   723  C C   . VAL A 1 97  ? 10.96270  -5.14306  40.73877 1.000 48.87021  ? 105 VAL A C   1 
ATOM   724  O O   . VAL A 1 97  ? 10.40712  -4.03810  40.72094 1.000 47.23138  ? 105 VAL A O   1 
ATOM   725  C CB  . VAL A 1 97  ? 10.03847  -6.37660  38.75971 1.000 48.84243  ? 105 VAL A CB  1 
ATOM   726  C CG1 . VAL A 1 97  ? 11.36982  -6.57681  38.05427 1.000 42.13263  ? 105 VAL A CG1 1 
ATOM   727  C CG2 . VAL A 1 97  ? 9.01670   -7.42501  38.32842 1.000 46.53482  ? 105 VAL A CG2 1 
ATOM   728  N N   . LEU A 1 98  ? 12.21982  -5.32768  41.13456 1.000 47.36319  ? 106 LEU A N   1 
ATOM   729  C CA  . LEU A 1 98  ? 13.09404  -4.24898  41.56842 1.000 48.43602  ? 106 LEU A CA  1 
ATOM   730  C C   . LEU A 1 98  ? 14.29141  -4.16143  40.62902 1.000 47.05917  ? 106 LEU A C   1 
ATOM   731  O O   . LEU A 1 98  ? 15.00848  -5.15009  40.43876 1.000 43.45296  ? 106 LEU A O   1 
ATOM   732  C CB  . LEU A 1 98  ? 13.53720  -4.49324  43.02043 1.000 51.24795  ? 106 LEU A CB  1 
ATOM   733  C CG  . LEU A 1 98  ? 14.67372  -3.70226  43.66922 1.000 55.86710  ? 106 LEU A CG  1 
ATOM   734  C CD1 . LEU A 1 98  ? 14.54959  -2.21240  43.42890 1.000 54.46999  ? 106 LEU A CD1 1 
ATOM   735  C CD2 . LEU A 1 98  ? 14.67459  -3.98658  45.15994 1.000 59.81996  ? 106 LEU A CD2 1 
ATOM   736  N N   . GLU A 1 99  ? 14.51279  -2.97482  40.05985 1.000 45.50580  ? 107 GLU A N   1 
ATOM   737  C CA  . GLU A 1 99  ? 15.60558  -2.72346  39.12375 1.000 45.34853  ? 107 GLU A CA  1 
ATOM   738  C C   . GLU A 1 99  ? 16.51106  -1.63571  39.68754 1.000 46.58214  ? 107 GLU A C   1 
ATOM   739  O O   . GLU A 1 99  ? 16.02268  -0.57773  40.10439 1.000 43.56202  ? 107 GLU A O   1 
ATOM   740  C CB  . GLU A 1 99  ? 15.05827  -2.32385  37.74868 1.000 42.96563  ? 107 GLU A CB  1 
ATOM   741  C CG  . GLU A 1 99  ? 14.22961  -3.44203  37.11832 1.000 42.34783  ? 107 GLU A CG  1 
ATOM   742  C CD  . GLU A 1 99  ? 13.63090  -3.07300  35.78073 1.000 41.84406  ? 107 GLU A CD  1 
ATOM   743  O OE1 . GLU A 1 99  ? 12.68112  -2.26112  35.73796 1.000 45.30561  ? 107 GLU A OE1 1 
ATOM   744  O OE2 . GLU A 1 99  ? 14.12727  -3.58503  34.75746 1.000 41.19639  ? 107 GLU A OE2 1 
ATOM   745  N N   . LEU A 1 100 ? 17.82402  -1.90685  39.72390 1.000 40.62724  ? 108 LEU A N   1 
ATOM   746  C CA  . LEU A 1 100 ? 18.81626  -0.96405  40.22537 1.000 41.98564  ? 108 LEU A CA  1 
ATOM   747  C C   . LEU A 1 100 ? 19.70053  -0.49983  39.07148 1.000 41.70169  ? 108 LEU A C   1 
ATOM   748  O O   . LEU A 1 100 ? 20.31971  -1.32242  38.38769 1.000 41.11752  ? 108 LEU A O   1 
ATOM   749  C CB  . LEU A 1 100 ? 19.66535  -1.61644  41.31403 1.000 48.10439  ? 108 LEU A CB  1 
ATOM   750  C CG  . LEU A 1 100 ? 18.96159  -2.05776  42.59444 1.000 44.93865  ? 108 LEU A CG  1 
ATOM   751  C CD1 . LEU A 1 100 ? 19.81275  -3.12443  43.28114 1.000 47.39076  ? 108 LEU A CD1 1 
ATOM   752  C CD2 . LEU A 1 100 ? 18.73556  -0.86602  43.51455 1.000 41.22311  ? 108 LEU A CD2 1 
ATOM   753  N N   . GLU A 1 101 ? 19.77706  0.80760   38.86115 1.000 43.47126  ? 109 GLU A N   1 
ATOM   754  C CA  . GLU A 1 101 ? 20.59776  1.29549   37.76641 1.000 46.63763  ? 109 GLU A CA  1 
ATOM   755  C C   . GLU A 1 101 ? 21.47434  2.45544   38.21787 1.000 47.93101  ? 109 GLU A C   1 
ATOM   756  O O   . GLU A 1 101 ? 21.08440  3.23307   39.09334 1.000 45.39533  ? 109 GLU A O   1 
ATOM   757  C CB  . GLU A 1 101 ? 19.72264  1.72445   36.58811 1.000 45.67032  ? 109 GLU A CB  1 
ATOM   758  C CG  . GLU A 1 101 ? 18.72403  2.77703   36.93077 1.000 47.24223  ? 109 GLU A CG  1 
ATOM   759  C CD  . GLU A 1 101 ? 18.06656  3.32147   35.69874 1.000 53.58964  ? 109 GLU A CD  1 
ATOM   760  O OE1 . GLU A 1 101 ? 17.64782  2.50235   34.83978 1.000 48.62603  ? 109 GLU A OE1 1 
ATOM   761  O OE2 . GLU A 1 101 ? 18.02192  4.56867   35.56685 1.000 57.23657  ? 109 GLU A OE2 1 
ATOM   762  N N   . PRO A 1 102 ? 22.68293  2.57447   37.66544 1.000 53.05561  ? 110 PRO A N   1 
ATOM   763  C CA  . PRO A 1 102 ? 23.57489  3.64254   38.11469 1.000 49.73083  ? 110 PRO A CA  1 
ATOM   764  C C   . PRO A 1 102 ? 22.97249  5.00585   37.82579 1.000 49.21472  ? 110 PRO A C   1 
ATOM   765  O O   . PRO A 1 102 ? 22.20536  5.19133   36.87549 1.000 52.00736  ? 110 PRO A O   1 
ATOM   766  C CB  . PRO A 1 102 ? 24.86209  3.39935   37.31633 1.000 48.49413  ? 110 PRO A CB  1 
ATOM   767  C CG  . PRO A 1 102 ? 24.83244  1.93694   37.02735 1.000 48.77259  ? 110 PRO A CG  1 
ATOM   768  C CD  . PRO A 1 102 ? 23.37390  1.64379   36.75737 1.000 49.97850  ? 110 PRO A CD  1 
ATOM   769  N N   . ALA A 1 103 ? 23.31130  5.94943   38.69844 1.000 48.50206  ? 111 ALA A N   1 
ATOM   770  C CA  . ALA A 1 103 ? 22.80879  7.31083   38.66535 1.000 49.95709  ? 111 ALA A CA  1 
ATOM   771  C C   . ALA A 1 103 ? 23.96006  8.23974   39.00282 1.000 48.45488  ? 111 ALA A C   1 
ATOM   772  O O   . ALA A 1 103 ? 24.94327  7.83197   39.62273 1.000 47.62522  ? 111 ALA A O   1 
ATOM   773  C CB  . ALA A 1 103 ? 21.66705  7.51004   39.66612 1.000 46.91808  ? 111 ALA A CB  1 
ATOM   774  N N   . GLU A 1 104 ? 23.84128  9.48923   38.56987 1.000 50.57107  ? 112 GLU A N   1 
ATOM   775  C CA  . GLU A 1 104 ? 24.76630  10.50629  39.03474 1.000 57.16718  ? 112 GLU A CA  1 
ATOM   776  C C   . GLU A 1 104 ? 24.55819  10.76982  40.52185 1.000 62.61233  ? 112 GLU A C   1 
ATOM   777  O O   . GLU A 1 104 ? 23.51710  10.45070  41.10203 1.000 62.85220  ? 112 GLU A O   1 
ATOM   778  C CB  . GLU A 1 104 ? 24.59317  11.80128  38.23897 1.000 61.29018  ? 112 GLU A CB  1 
ATOM   779  C CG  . GLU A 1 104 ? 24.71217  11.60869  36.73216 1.000 59.84448  ? 112 GLU A CG  1 
ATOM   780  C CD  . GLU A 1 104 ? 24.66160  12.91179  35.96484 1.000 57.80595  ? 112 GLU A CD  1 
ATOM   781  O OE1 . GLU A 1 104 ? 24.19440  13.92279  36.54382 1.000 60.74277  ? 112 GLU A OE1 1 
ATOM   782  O OE2 . GLU A 1 104 ? 25.06449  12.91257  34.77608 1.000 57.03776  ? 112 GLU A OE2 1 
ATOM   783  N N   . LEU A 1 105 ? 25.57087  11.35796  41.14680 1.000 69.16997  ? 113 LEU A N   1 
ATOM   784  C CA  . LEU A 1 105 ? 25.46123  11.66691  42.56379 1.000 73.10373  ? 113 LEU A CA  1 
ATOM   785  C C   . LEU A 1 105 ? 24.62478  12.92245  42.78293 1.000 82.03316  ? 113 LEU A C   1 
ATOM   786  O O   . LEU A 1 105 ? 24.58195  13.83103  41.94574 1.000 83.09591  ? 113 LEU A O   1 
ATOM   787  C CB  . LEU A 1 105 ? 26.84205  11.84133  43.20114 1.000 72.15714  ? 113 LEU A CB  1 
ATOM   788  C CG  . LEU A 1 105 ? 27.12064  10.72797  44.20589 1.000 67.48839  ? 113 LEU A CG  1 
ATOM   789  C CD1 . LEU A 1 105 ? 28.44350  10.92905  44.91035 1.000 69.35168  ? 113 LEU A CD1 1 
ATOM   790  C CD2 . LEU A 1 105 ? 25.96764  10.64576  45.21300 1.000 73.05339  ? 113 LEU A CD2 1 
ATOM   791  N N   . GLN A 1 106 ? 23.91584  12.93954  43.90667 1.000 91.06027  ? 114 GLN A N   1 
ATOM   792  C CA  . GLN A 1 106 ? 23.15374  14.10682  44.34268 1.000 96.91252  ? 114 GLN A CA  1 
ATOM   793  C C   . GLN A 1 106 ? 23.63329  14.40093  45.75718 1.000 104.45723 ? 114 GLN A C   1 
ATOM   794  O O   . GLN A 1 106 ? 23.22107  13.71643  46.71155 1.000 107.49015 ? 114 GLN A O   1 
ATOM   795  C CB  . GLN A 1 106 ? 21.64910  13.85567  44.30152 1.000 95.18192  ? 114 GLN A CB  1 
ATOM   796  C CG  . GLN A 1 106 ? 21.08817  13.72990  42.88851 1.000 98.99472  ? 114 GLN A CG  1 
ATOM   797  C CD  . GLN A 1 106 ? 21.29901  14.98541  42.05118 1.000 101.36146 ? 114 GLN A CD  1 
ATOM   798  O OE1 . GLN A 1 106 ? 20.91347  16.08468  42.45589 1.000 102.03338 ? 114 GLN A OE1 1 
ATOM   799  N NE2 . GLN A 1 106 ? 21.93679  14.82936  40.88910 1.000 93.47402  ? 114 GLN A NE2 1 
ATOM   800  N N   . PRO A 1 107 ? 24.51811  15.38547  45.93340 1.000 111.53006 ? 115 PRO A N   1 
ATOM   801  C CA  . PRO A 1 107 ? 25.01029  15.70217  47.27990 1.000 117.21597 ? 115 PRO A CA  1 
ATOM   802  C C   . PRO A 1 107 ? 24.52673  17.05629  47.77942 1.000 121.32891 ? 115 PRO A C   1 
ATOM   803  O O   . PRO A 1 107 ? 23.51901  17.14738  48.49163 1.000 120.46520 ? 115 PRO A O   1 
ATOM   804  C CB  . PRO A 1 107 ? 26.53609  15.68049  47.09768 1.000 114.38454 ? 115 PRO A CB  1 
ATOM   805  C CG  . PRO A 1 107 ? 26.76033  15.96709  45.58482 1.000 110.03398 ? 115 PRO A CG  1 
ATOM   806  C CD  . PRO A 1 107 ? 25.39426  15.96177  44.90084 1.000 108.14688 ? 115 PRO A CD  1 
ATOM   807  N N   . ASP A 1 108 ? 25.24542  18.11124  47.40004 1.000 122.99258 ? 116 ASP A N   1 
ATOM   808  C CA  . ASP A 1 108 ? 24.95315  19.47101  47.83516 1.000 124.62664 ? 116 ASP A CA  1 
ATOM   809  C C   . ASP A 1 108 ? 23.87762  20.12119  46.96260 1.000 124.65545 ? 116 ASP A C   1 
ATOM   810  O O   . ASP A 1 108 ? 23.69417  19.75715  45.79865 1.000 120.70475 ? 116 ASP A O   1 
ATOM   811  C CB  . ASP A 1 108 ? 26.23344  20.31185  47.81394 1.000 126.39209 ? 116 ASP A CB  1 
ATOM   812  C CG  . ASP A 1 108 ? 26.14467  21.53691  48.70306 1.000 132.90392 ? 116 ASP A CG  1 
ATOM   813  O OD1 . ASP A 1 108 ? 25.17747  21.63619  49.49139 1.000 134.13161 ? 116 ASP A OD1 1 
ATOM   814  O OD2 . ASP A 1 108 ? 27.04523  22.40047  48.61206 1.000 132.55562 ? 116 ASP A OD2 1 
ATOM   815  N N   . GLY A 1 129 ? 3.05281   24.33951  11.57346 1.000 62.54944  ? 137 GLY A N   1 
ATOM   816  C CA  . GLY A 1 129 ? 2.58333   23.00646  11.21152 1.000 60.27335  ? 137 GLY A CA  1 
ATOM   817  C C   . GLY A 1 129 ? 3.02126   21.85004  12.11102 1.000 56.37213  ? 137 GLY A C   1 
ATOM   818  O O   . GLY A 1 129 ? 3.69702   22.05036  13.13359 1.000 53.22032  ? 137 GLY A O   1 
ATOM   819  N N   . THR A 1 130 ? 2.59662   20.62772  11.76442 1.000 53.18128  ? 138 THR A N   1 
ATOM   820  C CA  . THR A 1 130 ? 2.96256   19.48073  12.59394 1.000 53.44230  ? 138 THR A CA  1 
ATOM   821  C C   . THR A 1 130 ? 4.45572   19.15823  12.46351 1.000 51.39102  ? 138 THR A C   1 
ATOM   822  O O   . THR A 1 130 ? 5.11118   18.81858  13.46230 1.000 48.63731  ? 138 THR A O   1 
ATOM   823  C CB  . THR A 1 130 ? 2.08109   18.25840  12.27890 1.000 56.55083  ? 138 THR A CB  1 
ATOM   824  O OG1 . THR A 1 130 ? 2.18755   17.30934  13.34601 1.000 58.56048  ? 138 THR A OG1 1 
ATOM   825  C CG2 . THR A 1 130 ? 2.52741   17.54868  11.00198 1.000 57.37858  ? 138 THR A CG2 1 
ATOM   826  N N   . GLN A 1 131 ? 5.01979   19.27411  11.24962 1.000 51.73673  ? 139 GLN A N   1 
ATOM   827  C CA  . GLN A 1 131 ? 6.45395   19.04921  11.07377 1.000 49.18653  ? 139 GLN A CA  1 
ATOM   828  C C   . GLN A 1 131 ? 7.26664   20.06541  11.86167 1.000 49.61955  ? 139 GLN A C   1 
ATOM   829  O O   . GLN A 1 131 ? 8.31564   19.73671  12.43330 1.000 48.91448  ? 139 GLN A O   1 
ATOM   830  C CB  . GLN A 1 131 ? 6.81789   19.10356  9.58299  1.000 49.97394  ? 139 GLN A CB  1 
ATOM   831  C CG  . GLN A 1 131 ? 8.32729   18.89860  9.30949  1.000 53.07923  ? 139 GLN A CG  1 
ATOM   832  C CD  . GLN A 1 131 ? 9.13085   20.22155  9.42915  1.000 60.68737  ? 139 GLN A CD  1 
ATOM   833  O OE1 . GLN A 1 131 ? 8.54155   21.31010  9.50254  1.000 67.11361  ? 139 GLN A OE1 1 
ATOM   834  N NE2 . GLN A 1 131 ? 10.45601  20.11215  9.55684  1.000 60.96693  ? 139 GLN A NE2 1 
ATOM   835  N N   . ALA A 1 132 ? 6.80893   21.31363  11.88416 1.000 47.88711  ? 140 ALA A N   1 
ATOM   836  C CA  . ALA A 1 132 ? 7.50066   22.32815  12.66174 1.000 45.65789  ? 140 ALA A CA  1 
ATOM   837  C C   . ALA A 1 132 ? 7.43003   22.01669  14.14884 1.000 45.91067  ? 140 ALA A C   1 
ATOM   838  O O   . ALA A 1 132 ? 8.41051   22.21760  14.87570 1.000 42.69164  ? 140 ALA A O   1 
ATOM   839  C CB  . ALA A 1 132 ? 6.89424   23.69957  12.38242 1.000 49.18249  ? 140 ALA A CB  1 
ATOM   840  N N   . LEU A 1 133 ? 6.27656   21.52428  14.62098 1.000 43.29650  ? 141 LEU A N   1 
ATOM   841  C CA  . LEU A 1 133 ? 6.16553   21.12809  16.02025 1.000 39.32653  ? 141 LEU A CA  1 
ATOM   842  C C   . LEU A 1 133 ? 7.15104   20.00787  16.33677 1.000 41.34532  ? 141 LEU A C   1 
ATOM   843  O O   . LEU A 1 133 ? 7.89420   20.07681  17.32469 1.000 39.47353  ? 141 LEU A O   1 
ATOM   844  C CB  . LEU A 1 133 ? 4.73519   20.69294  16.32810 1.000 41.00178  ? 141 LEU A CB  1 
ATOM   845  C CG  . LEU A 1 133 ? 4.55367   19.88184  17.60985 1.000 38.36899  ? 141 LEU A CG  1 
ATOM   846  C CD1 . LEU A 1 133 ? 4.79611   20.79505  18.78166 1.000 43.44366  ? 141 LEU A CD1 1 
ATOM   847  C CD2 . LEU A 1 133 ? 3.17663   19.25701  17.69482 1.000 43.03565  ? 141 LEU A CD2 1 
ATOM   848  N N   . LEU A 1 134 ? 7.21953   18.99687  15.46137 1.000 39.44240  ? 142 LEU A N   1 
ATOM   849  C CA  . LEU A 1 134 ? 8.12317   17.88032  15.67949 1.000 39.15650  ? 142 LEU A CA  1 
ATOM   850  C C   . LEU A 1 134 ? 9.58457   18.24699  15.43000 1.000 38.71014  ? 142 LEU A C   1 
ATOM   851  O O   . LEU A 1 134 ? 10.46837  17.61751  16.02259 1.000 36.31228  ? 142 LEU A O   1 
ATOM   852  C CB  . LEU A 1 134 ? 7.69692   16.68615  14.81356 1.000 40.79948  ? 142 LEU A CB  1 
ATOM   853  C CG  . LEU A 1 134 ? 6.66967   15.73846  15.48488 1.000 41.14405  ? 142 LEU A CG  1 
ATOM   854  C CD1 . LEU A 1 134 ? 7.16264   15.36301  16.89088 1.000 42.84221  ? 142 LEU A CD1 1 
ATOM   855  C CD2 . LEU A 1 134 ? 5.28429   16.29863  15.59025 1.000 39.54418  ? 142 LEU A CD2 1 
ATOM   856  N N   . GLN A 1 135 ? 9.86674   19.27479  14.61656 1.000 40.09871  ? 143 GLN A N   1 
ATOM   857  C CA  . GLN A 1 135 ? 11.25079  19.73038  14.49112 1.000 38.87510  ? 143 GLN A CA  1 
ATOM   858  C C   . GLN A 1 135 ? 11.75982  20.33528  15.79856 1.000 37.95579  ? 143 GLN A C   1 
ATOM   859  O O   . GLN A 1 135 ? 12.88153  20.03166  16.23136 1.000 37.94682  ? 143 GLN A O   1 
ATOM   860  C CB  . GLN A 1 135 ? 11.38411  20.71522  13.32916 1.000 42.18391  ? 143 GLN A CB  1 
ATOM   861  C CG  . GLN A 1 135 ? 12.80200  21.21127  13.07727 1.000 40.25330  ? 143 GLN A CG  1 
ATOM   862  C CD  . GLN A 1 135 ? 13.79428  20.08077  12.79822 1.000 45.36850  ? 143 GLN A CD  1 
ATOM   863  O OE1 . GLN A 1 135 ? 13.54162  19.19387  11.97873 1.000 46.54130  ? 143 GLN A OE1 1 
ATOM   864  N NE2 . GLN A 1 135 ? 14.92946  20.11071  13.48491 1.000 42.59486  ? 143 GLN A NE2 1 
ATOM   865  N N   . THR A 1 136 ? 10.95320  21.17354  16.45982 1.000 34.66483  ? 144 THR A N   1 
ATOM   866  C CA  . THR A 1 136 ? 11.37872  21.72018  17.74426 1.000 33.11716  ? 144 THR A CA  1 
ATOM   867  C C   . THR A 1 136 ? 11.51219  20.63336  18.79810 1.000 33.58249  ? 144 THR A C   1 
ATOM   868  O O   . THR A 1 136 ? 12.37231  20.72758  19.68973 1.000 34.95332  ? 144 THR A O   1 
ATOM   869  C CB  . THR A 1 136 ? 10.40792  22.78448  18.24306 1.000 33.54210  ? 144 THR A CB  1 
ATOM   870  O OG1 . THR A 1 136 ? 9.09965   22.21890  18.37588 1.000 39.14661  ? 144 THR A OG1 1 
ATOM   871  C CG2 . THR A 1 136 ? 10.35172  23.91253  17.26492 1.000 40.44020  ? 144 THR A CG2 1 
ATOM   872  N N   . ALA A 1 137 ? 10.64102  19.61929  18.73918 1.000 31.53328  ? 145 ALA A N   1 
ATOM   873  C CA  . ALA A 1 137 ? 10.77662  18.46371  19.61310 1.000 32.68382  ? 145 ALA A CA  1 
ATOM   874  C C   . ALA A 1 137 ? 12.10878  17.76520  19.38353 1.000 30.62110  ? 145 ALA A C   1 
ATOM   875  O O   . ALA A 1 137 ? 12.83214  17.46037  20.33648 1.000 33.17088  ? 145 ALA A O   1 
ATOM   876  C CB  . ALA A 1 137 ? 9.61041   17.49389  19.37537 1.000 36.29046  ? 145 ALA A CB  1 
ATOM   877  N N   . ALA A 1 138 ? 12.44926  17.51547  18.11357 1.000 33.34164  ? 146 ALA A N   1 
ATOM   878  C CA  . ALA A 1 138 ? 13.76021  16.98632  17.74771 1.000 34.02997  ? 146 ALA A CA  1 
ATOM   879  C C   . ALA A 1 138 ? 14.89856  17.82903  18.32032 1.000 35.17810  ? 146 ALA A C   1 
ATOM   880  O O   . ALA A 1 138 ? 15.83327  17.29698  18.92976 1.000 37.75532  ? 146 ALA A O   1 
ATOM   881  C CB  . ALA A 1 138 ? 13.88022  16.90338  16.22239 1.000 37.17097  ? 146 ALA A CB  1 
ATOM   882  N N   . ASP A 1 139 ? 14.84809  19.14942  18.13048 1.000 35.35752  ? 147 ASP A N   1 
ATOM   883  C CA  . ASP A 1 139 ? 15.91679  19.98815  18.66900 1.000 32.09652  ? 147 ASP A CA  1 
ATOM   884  C C   . ASP A 1 139 ? 15.90208  20.01241  20.18704 1.000 34.08960  ? 147 ASP A C   1 
ATOM   885  O O   . ASP A 1 139 ? 16.96457  20.05599  20.81818 1.000 36.09088  ? 147 ASP A O   1 
ATOM   886  C CB  . ASP A 1 139 ? 15.80617  21.42178  18.12854 1.000 35.06020  ? 147 ASP A CB  1 
ATOM   887  C CG  . ASP A 1 139 ? 16.08715  21.51223  16.63757 1.000 41.10647  ? 147 ASP A CG  1 
ATOM   888  O OD1 . ASP A 1 139 ? 17.06877  20.87441  16.16968 1.000 43.14474  ? 147 ASP A OD1 1 
ATOM   889  O OD2 . ASP A 1 139 ? 15.32702  22.22435  15.93756 1.000 37.70599  ? 147 ASP A OD2 1 
ATOM   890  N N   . THR A 1 140 ? 14.72061  19.97102  20.79385 1.000 31.79955  ? 148 THR A N   1 
ATOM   891  C CA  . THR A 1 140 ? 14.63844  19.99057  22.24961 1.000 32.08336  ? 148 THR A CA  1 
ATOM   892  C C   . THR A 1 140 ? 15.20707  18.71095  22.85357 1.000 33.63380  ? 148 THR A C   1 
ATOM   893  O O   . THR A 1 140 ? 15.95705  18.74940  23.83809 1.000 33.61795  ? 148 THR A O   1 
ATOM   894  C CB  . THR A 1 140 ? 13.18046  20.14323  22.67178 1.000 32.93366  ? 148 THR A CB  1 
ATOM   895  O OG1 . THR A 1 140 ? 12.63932  21.34313  22.09280 1.000 35.11677  ? 148 THR A OG1 1 
ATOM   896  C CG2 . THR A 1 140 ? 13.06995  20.15460  24.18070 1.000 27.71549  ? 148 THR A CG2 1 
ATOM   897  N N   . VAL A 1 141 ? 14.84958  17.55850  22.28878 1.000 31.17294  ? 149 VAL A N   1 
ATOM   898  C CA  . VAL A 1 141 ? 15.35643  16.31157  22.85102 1.000 35.20573  ? 149 VAL A CA  1 
ATOM   899  C C   . VAL A 1 141 ? 16.87056  16.21271  22.67537 1.000 32.51933  ? 149 VAL A C   1 
ATOM   900  O O   . VAL A 1 141 ? 17.59128  15.81463  23.60404 1.000 36.02671  ? 149 VAL A O   1 
ATOM   901  C CB  . VAL A 1 141 ? 14.61061  15.11576  22.23448 1.000 33.64603  ? 149 VAL A CB  1 
ATOM   902  C CG1 . VAL A 1 141 ? 15.24574  13.78269  22.70999 1.000 31.77707  ? 149 VAL A CG1 1 
ATOM   903  C CG2 . VAL A 1 141 ? 13.21576  15.16548  22.66923 1.000 27.99769  ? 149 VAL A CG2 1 
ATOM   904  N N   . ARG A 1 142 ? 17.39347  16.61181  21.51518 1.000 34.77793  ? 150 ARG A N   1 
ATOM   905  C CA  . ARG A 1 142 ? 18.85614  16.58160  21.35535 1.000 36.80603  ? 150 ARG A CA  1 
ATOM   906  C C   . ARG A 1 142 ? 19.55462  17.47099  22.37965 1.000 37.80012  ? 150 ARG A C   1 
ATOM   907  O O   . ARG A 1 142 ? 20.64832  17.13532  22.86066 1.000 38.50128  ? 150 ARG A O   1 
ATOM   908  C CB  . ARG A 1 142 ? 19.27753  16.99319  19.93947 1.000 40.22171  ? 150 ARG A CB  1 
ATOM   909  C CG  . ARG A 1 142 ? 20.81994  16.91700  19.73443 1.000 37.88439  ? 150 ARG A CG  1 
ATOM   910  C CD  . ARG A 1 142 ? 21.24711  16.93783  18.27528 1.000 41.85448  ? 150 ARG A CD  1 
ATOM   911  N NE  . ARG A 1 142 ? 21.23681  18.28998  17.73220 1.000 47.10640  ? 150 ARG A NE  1 
ATOM   912  C CZ  . ARG A 1 142 ? 22.23153  19.15557  17.87780 1.000 44.91103  ? 150 ARG A CZ  1 
ATOM   913  N NH1 . ARG A 1 142 ? 23.33201  18.83290  18.53111 1.000 44.15152  ? 150 ARG A NH1 1 
ATOM   914  N NH2 . ARG A 1 142 ? 22.11393  20.37723  17.35830 1.000 41.01830  ? 150 ARG A NH2 1 
ATOM   915  N N   . ALA A 1 143 ? 18.93872  18.59229  22.74552 1.000 34.06255  ? 151 ALA A N   1 
ATOM   916  C CA  . ALA A 1 143 ? 19.54448  19.44570  23.75913 1.000 36.45977  ? 151 ALA A CA  1 
ATOM   917  C C   . ALA A 1 143 ? 19.51669  18.78840  25.13365 1.000 36.94204  ? 151 ALA A C   1 
ATOM   918  O O   . ALA A 1 143 ? 20.48719  18.90048  25.89863 1.000 38.52151  ? 151 ALA A O   1 
ATOM   919  C CB  . ALA A 1 143 ? 18.82639  20.79670  23.79264 1.000 37.05131  ? 151 ALA A CB  1 
ATOM   920  N N   . LEU A 1 144 ? 18.42896  18.07153  25.45302 1.000 33.20408  ? 152 LEU A N   1 
ATOM   921  C CA  . LEU A 1 144 ? 18.28034  17.46735  26.77572 1.000 34.45423  ? 152 LEU A CA  1 
ATOM   922  C C   . LEU A 1 144 ? 19.17215  16.23390  26.93857 1.000 32.91153  ? 152 LEU A C   1 
ATOM   923  O O   . LEU A 1 144 ? 19.70968  15.99680  28.02322 1.000 34.30410  ? 152 LEU A O   1 
ATOM   924  C CB  . LEU A 1 144 ? 16.80799  17.10475  27.02940 1.000 32.18456  ? 152 LEU A CB  1 
ATOM   925  C CG  . LEU A 1 144 ? 15.87798  18.19863  27.59184 1.000 36.22365  ? 152 LEU A CG  1 
ATOM   926  C CD1 . LEU A 1 144 ? 14.43053  17.77138  27.44471 1.000 36.52957  ? 152 LEU A CD1 1 
ATOM   927  C CD2 . LEU A 1 144 ? 16.19115  18.52455  29.05356 1.000 35.99542  ? 152 LEU A CD2 1 
ATOM   928  N N   . THR A 1 145 ? 19.31278  15.42474  25.88857 1.000 31.27132  ? 153 THR A N   1 
ATOM   929  C CA  . THR A 1 145 ? 20.12536  14.20926  25.93941 1.000 36.11503  ? 153 THR A CA  1 
ATOM   930  C C   . THR A 1 145 ? 21.60423  14.42641  25.59509 1.000 43.41943  ? 153 THR A C   1 
ATOM   931  O O   . THR A 1 145 ? 22.47477  13.68386  26.09011 1.000 38.13572  ? 153 THR A O   1 
ATOM   932  C CB  . THR A 1 145 ? 19.55340  13.16443  24.97773 1.000 37.26442  ? 153 THR A CB  1 
ATOM   933  O OG1 . THR A 1 145 ? 19.67561  13.63935  23.62942 1.000 34.25447  ? 153 THR A OG1 1 
ATOM   934  C CG2 . THR A 1 145 ? 18.06247  12.87773  25.32508 1.000 28.72302  ? 153 THR A CG2 1 
ATOM   935  N N   . GLY A 1 146 ? 21.91907  15.41346  24.74774 1.000 43.84299  ? 154 GLY A N   1 
ATOM   936  C CA  . GLY A 1 146 ? 23.26477  15.52701  24.24380 1.000 42.43728  ? 154 GLY A CA  1 
ATOM   937  C C   . GLY A 1 146 ? 23.64382  14.49052  23.21211 1.000 40.77456  ? 154 GLY A C   1 
ATOM   938  O O   . GLY A 1 146 ? 24.80059  14.46620  22.78955 1.000 45.72384  ? 154 GLY A O   1 
ATOM   939  N N   . PHE A 1 147 ? 22.72375  13.62771  22.79586 1.000 39.58662  ? 155 PHE A N   1 
ATOM   940  C CA  . PHE A 1 147 ? 23.08255  12.60021  21.83098 1.000 41.47908  ? 155 PHE A CA  1 
ATOM   941  C C   . PHE A 1 147 ? 23.39959  13.22891  20.47993 1.000 45.90617  ? 155 PHE A C   1 
ATOM   942  O O   . PHE A 1 147 ? 22.86329  14.28260  20.11916 1.000 46.29778  ? 155 PHE A O   1 
ATOM   943  C CB  . PHE A 1 147 ? 21.97101  11.56141  21.66462 1.000 36.09418  ? 155 PHE A CB  1 
ATOM   944  C CG  . PHE A 1 147 ? 21.93292  10.50826  22.75402 1.000 37.66172  ? 155 PHE A CG  1 
ATOM   945  C CD1 . PHE A 1 147 ? 22.37449  10.78424  24.04513 1.000 36.35329  ? 155 PHE A CD1 1 
ATOM   946  C CD2 . PHE A 1 147 ? 21.46805  9.22647   22.47489 1.000 36.42804  ? 155 PHE A CD2 1 
ATOM   947  C CE1 . PHE A 1 147 ? 22.33755  9.79423   25.05024 1.000 36.49935  ? 155 PHE A CE1 1 
ATOM   948  C CE2 . PHE A 1 147 ? 21.43669  8.24487   23.45976 1.000 34.88174  ? 155 PHE A CE2 1 
ATOM   949  C CZ  . PHE A 1 147 ? 21.86611  8.52690   24.75242 1.000 31.08608  ? 155 PHE A CZ  1 
ATOM   950  N N   . ASP A 1 148 ? 24.30235  12.56783  19.74264 1.000 46.42686  ? 156 ASP A N   1 
ATOM   951  C CA  . ASP A 1 148 ? 24.72340  13.04270  18.42698 1.000 47.47253  ? 156 ASP A CA  1 
ATOM   952  C C   . ASP A 1 148 ? 23.53742  13.27629  17.50706 1.000 46.28285  ? 156 ASP A C   1 
ATOM   953  O O   . ASP A 1 148 ? 23.44150  14.31564  16.84558 1.000 48.13312  ? 156 ASP A O   1 
ATOM   954  C CB  . ASP A 1 148 ? 25.66426  12.03218  17.76946 1.000 45.64929  ? 156 ASP A CB  1 
ATOM   955  C CG  . ASP A 1 148 ? 27.01278  11.96441  18.43281 1.000 49.87853  ? 156 ASP A CG  1 
ATOM   956  O OD1 . ASP A 1 148 ? 27.45196  13.00241  18.97123 1.000 48.93306  ? 156 ASP A OD1 1 
ATOM   957  O OD2 . ASP A 1 148 ? 27.63614  10.86843  18.38976 1.000 47.94360  ? 156 ASP A OD2 1 
ATOM   958  N N   . ARG A 1 149 ? 22.62740  12.30867  17.44177 1.000 42.19019  ? 157 ARG A N   1 
ATOM   959  C CA  . ARG A 1 149 ? 21.57775  12.32643  16.44633 1.000 39.23946  ? 157 ARG A CA  1 
ATOM   960  C C   . ARG A 1 149 ? 20.25662  12.02262  17.12492 1.000 45.99302  ? 157 ARG A C   1 
ATOM   961  O O   . ARG A 1 149 ? 20.19805  11.22203  18.07044 1.000 39.13252  ? 157 ARG A O   1 
ATOM   962  C CB  . ARG A 1 149 ? 21.84167  11.32196  15.32166 1.000 42.78503  ? 157 ARG A CB  1 
ATOM   963  C CG  . ARG A 1 149 ? 20.94755  11.57299  14.13757 1.000 50.67552  ? 157 ARG A CG  1 
ATOM   964  C CD  . ARG A 1 149 ? 20.98835  10.53030  13.01285 1.000 62.40145  ? 157 ARG A CD  1 
ATOM   965  N NE  . ARG A 1 149 ? 21.08519  9.13603   13.43357 1.000 66.09087  ? 157 ARG A NE  1 
ATOM   966  C CZ  . ARG A 1 149 ? 21.17266  8.11305   12.58722 1.000 73.48933  ? 157 ARG A CZ  1 
ATOM   967  N NH1 . ARG A 1 149 ? 21.10924  8.29303   11.27303 1.000 78.07818  ? 157 ARG A NH1 1 
ATOM   968  N NH2 . ARG A 1 149 ? 21.31772  6.87779   13.06891 1.000 69.45221  ? 157 ARG A NH2 1 
ATOM   969  N N   . VAL A 1 150 ? 19.21392  12.71475  16.65401 1.000 44.82883  ? 158 VAL A N   1 
ATOM   970  C CA  . VAL A 1 150 ? 17.83665  12.54009  17.09079 1.000 42.20802  ? 158 VAL A CA  1 
ATOM   971  C C   . VAL A 1 150 ? 16.95500  12.49627  15.85964 1.000 42.72359  ? 158 VAL A C   1 
ATOM   972  O O   . VAL A 1 150 ? 16.98609  13.42199  15.04499 1.000 47.17592  ? 158 VAL A O   1 
ATOM   973  C CB  . VAL A 1 150 ? 17.38808  13.68765  18.01184 1.000 42.26321  ? 158 VAL A CB  1 
ATOM   974  C CG1 . VAL A 1 150 ? 15.89655  13.66042  18.19281 1.000 35.67531  ? 158 VAL A CG1 1 
ATOM   975  C CG2 . VAL A 1 150 ? 18.11671  13.60315  19.35444 1.000 40.34926  ? 158 VAL A CG2 1 
ATOM   976  N N   . MET A 1 151 ? 16.13866  11.46064  15.74740 1.000 39.96368  ? 159 MET A N   1 
ATOM   977  C CA  . MET A 1 151 ? 15.20242  11.30199  14.63682 1.000 43.68787  ? 159 MET A CA  1 
ATOM   978  C C   . MET A 1 151 ? 13.76634  11.18732  15.15510 1.000 40.68029  ? 159 MET A C   1 
ATOM   979  O O   . MET A 1 151 ? 13.51047  10.53559  16.17350 1.000 41.79750  ? 159 MET A O   1 
ATOM   980  C CB  . MET A 1 151 ? 15.55616  10.05324  13.83660 1.000 44.64922  ? 159 MET A CB  1 
ATOM   981  C CG  . MET A 1 151 ? 17.04682  9.96755   13.52748 1.000 56.12266  ? 159 MET A CG  1 
ATOM   982  S SD  . MET A 1 151 ? 17.29075  9.57024   11.81468 1.000 72.22329  ? 159 MET A SD  1 
ATOM   983  C CE  . MET A 1 151 ? 16.70612  11.09751  11.08415 1.000 56.65016  ? 159 MET A CE  1 
ATOM   984  N N   . VAL A 1 152 ? 12.82269  11.79296  14.44380 1.000 39.65329  ? 160 VAL A N   1 
ATOM   985  C CA  . VAL A 1 152 ? 11.40697  11.70818  14.78094 1.000 36.28850  ? 160 VAL A CA  1 
ATOM   986  C C   . VAL A 1 152 ? 10.69164  10.95119  13.67618 1.000 40.72700  ? 160 VAL A C   1 
ATOM   987  O O   . VAL A 1 152 ? 10.70211  11.38478  12.51857 1.000 44.98216  ? 160 VAL A O   1 
ATOM   988  C CB  . VAL A 1 152 ? 10.78371  13.09490  14.98194 1.000 39.13455  ? 160 VAL A CB  1 
ATOM   989  C CG1 . VAL A 1 152 ? 9.28430   12.95011  15.38947 1.000 34.95432  ? 160 VAL A CG1 1 
ATOM   990  C CG2 . VAL A 1 152 ? 11.59558  13.90157  16.01330 1.000 35.37532  ? 160 VAL A CG2 1 
ATOM   991  N N   . TYR A 1 153 ? 10.07307  9.82264   14.02584 1.000 38.88773  ? 161 TYR A N   1 
ATOM   992  C CA  . TYR A 1 153 ? 9.25090   9.06041   13.09358 1.000 37.29460  ? 161 TYR A CA  1 
ATOM   993  C C   . TYR A 1 153 ? 7.78362   9.27730   13.41586 1.000 38.73419  ? 161 TYR A C   1 
ATOM   994  O O   . TYR A 1 153 ? 7.41102   9.36893   14.58534 1.000 41.62137  ? 161 TYR A O   1 
ATOM   995  C CB  . TYR A 1 153 ? 9.55717   7.56268   13.16613 1.000 43.25449  ? 161 TYR A CB  1 
ATOM   996  C CG  . TYR A 1 153 ? 11.02087  7.18252   13.04319 1.000 43.73056  ? 161 TYR A CG  1 
ATOM   997  C CD1 . TYR A 1 153 ? 11.60438  6.95494   11.80860 1.000 46.41662  ? 161 TYR A CD1 1 
ATOM   998  C CD2 . TYR A 1 153 ? 11.80313  7.00772   14.17141 1.000 42.52304  ? 161 TYR A CD2 1 
ATOM   999  C CE1 . TYR A 1 153 ? 12.93900  6.59852   11.69689 1.000 46.45060  ? 161 TYR A CE1 1 
ATOM   1000 C CE2 . TYR A 1 153 ? 13.13917  6.65288   14.07223 1.000 45.59275  ? 161 TYR A CE2 1 
ATOM   1001 C CZ  . TYR A 1 153 ? 13.70590  6.43973   12.83079 1.000 51.02176  ? 161 TYR A CZ  1 
ATOM   1002 O OH  . TYR A 1 153 ? 15.05253  6.07903   12.73110 1.000 48.94120  ? 161 TYR A OH  1 
ATOM   1003 N N   . ARG A 1 154 ? 6.95562   9.37180   12.37789 1.000 39.51381  ? 162 ARG A N   1 
ATOM   1004 C CA  . ARG A 1 154 ? 5.50294   9.31586   12.49363 1.000 40.45307  ? 162 ARG A CA  1 
ATOM   1005 C C   . ARG A 1 154 ? 4.98165   8.09882   11.74831 1.000 40.28563  ? 162 ARG A C   1 
ATOM   1006 O O   . ARG A 1 154 ? 5.38319   7.85029   10.61074 1.000 43.66850  ? 162 ARG A O   1 
ATOM   1007 C CB  . ARG A 1 154 ? 4.82423   10.56761  11.93205 1.000 42.54057  ? 162 ARG A CB  1 
ATOM   1008 C CG  . ARG A 1 154 ? 3.31766   10.40766  11.84221 1.000 45.25705  ? 162 ARG A CG  1 
ATOM   1009 C CD  . ARG A 1 154 ? 2.62435   11.70109  11.52675 1.000 46.62207  ? 162 ARG A CD  1 
ATOM   1010 N NE  . ARG A 1 154 ? 3.12745   12.28815  10.29263 1.000 53.09166  ? 162 ARG A NE  1 
ATOM   1011 C CZ  . ARG A 1 154 ? 2.64406   13.39294  9.73911  1.000 61.12607  ? 162 ARG A CZ  1 
ATOM   1012 N NH1 . ARG A 1 154 ? 1.61738   14.04246  10.27144 1.000 64.71272  ? 162 ARG A NH1 1 
ATOM   1013 N NH2 . ARG A 1 154 ? 3.22366   13.87507  8.64213  1.000 60.76952  ? 162 ARG A NH2 1 
ATOM   1014 N N   . PHE A 1 155 ? 4.07606   7.36118   12.37620 1.000 36.50748  ? 163 PHE A N   1 
ATOM   1015 C CA  . PHE A 1 155 ? 3.55601   6.14110   11.77640 1.000 42.80597  ? 163 PHE A CA  1 
ATOM   1016 C C   . PHE A 1 155 ? 2.41362   6.45765   10.82554 1.000 47.88012  ? 163 PHE A C   1 
ATOM   1017 O O   . PHE A 1 155 ? 1.50354   7.21627   11.17281 1.000 46.46258  ? 163 PHE A O   1 
ATOM   1018 C CB  . PHE A 1 155 ? 3.09876   5.16931   12.86888 1.000 41.51027  ? 163 PHE A CB  1 
ATOM   1019 C CG  . PHE A 1 155 ? 4.24469   4.55366   13.63042 1.000 38.82275  ? 163 PHE A CG  1 
ATOM   1020 C CD1 . PHE A 1 155 ? 5.07964   3.64509   13.00802 1.000 36.08978  ? 163 PHE A CD1 1 
ATOM   1021 C CD2 . PHE A 1 155 ? 4.49284   4.89999   14.94763 1.000 33.89980  ? 163 PHE A CD2 1 
ATOM   1022 C CE1 . PHE A 1 155 ? 6.15286   3.09064   13.67769 1.000 37.75207  ? 163 PHE A CE1 1 
ATOM   1023 C CE2 . PHE A 1 155 ? 5.55911   4.34395   15.62939 1.000 34.67426  ? 163 PHE A CE2 1 
ATOM   1024 C CZ  . PHE A 1 155 ? 6.39395   3.44081   14.99373 1.000 35.75776  ? 163 PHE A CZ  1 
ATOM   1025 N N   . ASP A 1 156 ? 2.47755   5.89928   9.61404  1.000 50.58034  ? 164 ASP A N   1 
ATOM   1026 C CA  . ASP A 1 156 ? 1.38999   6.02740   8.65426  1.000 51.44036  ? 164 ASP A CA  1 
ATOM   1027 C C   . ASP A 1 156 ? 0.36913   4.91323   8.88528  1.000 52.70113  ? 164 ASP A C   1 
ATOM   1028 O O   . ASP A 1 156 ? 0.37621   4.22837   9.91225  1.000 52.38263  ? 164 ASP A O   1 
ATOM   1029 C CB  . ASP A 1 156 ? 1.91790   6.05474   7.21226  1.000 52.42571  ? 164 ASP A CB  1 
ATOM   1030 C CG  . ASP A 1 156 ? 2.50467   4.71838   6.74119  1.000 53.94545  ? 164 ASP A CG  1 
ATOM   1031 O OD1 . ASP A 1 156 ? 2.36558   3.69400   7.42589  1.000 55.20703  ? 164 ASP A OD1 1 
ATOM   1032 O OD2 . ASP A 1 156 ? 3.12661   4.69307   5.65439  1.000 57.36480  ? 164 ASP A OD2 1 
ATOM   1033 N N   . ALA A 1 157 ? -0.53356  4.73681   7.91921  1.000 55.83494  ? 165 ALA A N   1 
ATOM   1034 C CA  . ALA A 1 157 ? -1.61460  3.76701   8.03428  1.000 53.57627  ? 165 ALA A CA  1 
ATOM   1035 C C   . ALA A 1 157 ? -1.13051  2.32438   7.93302  1.000 59.60542  ? 165 ALA A C   1 
ATOM   1036 O O   . ALA A 1 157 ? -1.86763  1.40775   8.30068  1.000 65.44184  ? 165 ALA A O   1 
ATOM   1037 C CB  . ALA A 1 157 ? -2.67054  4.02592   6.96724  1.000 51.15348  ? 165 ALA A CB  1 
ATOM   1038 N N   . ASP A 1 158 ? 0.03687   2.08071   7.36121  1.000 54.97656  ? 166 ASP A N   1 
ATOM   1039 C CA  . ASP A 1 158 ? 0.60236   0.74302   7.37397  1.000 54.09245  ? 166 ASP A CA  1 
ATOM   1040 C C   . ASP A 1 158 ? 1.59157   0.55698   8.50970  1.000 52.95250  ? 166 ASP A C   1 
ATOM   1041 O O   . ASP A 1 158 ? 2.33237   -0.43166  8.51724  1.000 52.45104  ? 166 ASP A O   1 
ATOM   1042 C CB  . ASP A 1 158 ? 1.25115   0.43542   6.02769  1.000 55.95079  ? 166 ASP A CB  1 
ATOM   1043 C CG  . ASP A 1 158 ? 0.27418   0.58977   4.86430  1.000 61.91313  ? 166 ASP A CG  1 
ATOM   1044 O OD1 . ASP A 1 158 ? -0.96064  0.43247   5.06946  1.000 58.29017  ? 166 ASP A OD1 1 
ATOM   1045 O OD2 . ASP A 1 158 ? 0.74469   0.88029   3.74131  1.000 68.64676  ? 166 ASP A OD2 1 
ATOM   1046 N N   . TRP A 1 159 ? 1.61526   1.49208   9.46698  1.000 52.98690  ? 167 TRP A N   1 
ATOM   1047 C CA  . TRP A 1 159 ? 2.53842   1.46049   10.60336 1.000 48.93315  ? 167 TRP A CA  1 
ATOM   1048 C C   . TRP A 1 159 ? 4.00354   1.43648   10.15325 1.000 50.42782  ? 167 TRP A C   1 
ATOM   1049 O O   . TRP A 1 159 ? 4.84948   0.76401   10.75750 1.000 43.82027  ? 167 TRP A O   1 
ATOM   1050 C CB  . TRP A 1 159 ? 2.22823   0.28602   11.53957 1.000 48.63726  ? 167 TRP A CB  1 
ATOM   1051 C CG  . TRP A 1 159 ? 0.96177   0.44115   12.33791 1.000 44.40495  ? 167 TRP A CG  1 
ATOM   1052 C CD1 . TRP A 1 159 ? -0.21545  -0.22784  12.15789 1.000 49.85764  ? 167 TRP A CD1 1 
ATOM   1053 C CD2 . TRP A 1 159 ? 0.75304   1.32966   13.44344 1.000 45.76715  ? 167 TRP A CD2 1 
ATOM   1054 N NE1 . TRP A 1 159 ? -1.14111  0.17875   13.09305 1.000 44.42666  ? 167 TRP A NE1 1 
ATOM   1055 C CE2 . TRP A 1 159 ? -0.57683  1.14292   13.88598 1.000 44.32533  ? 167 TRP A CE2 1 
ATOM   1056 C CE3 . TRP A 1 159 ? 1.56252   2.26856   14.10202 1.000 41.13411  ? 167 TRP A CE3 1 
ATOM   1057 C CZ2 . TRP A 1 159 ? -1.11734  1.85375   14.96267 1.000 43.84743  ? 167 TRP A CZ2 1 
ATOM   1058 C CZ3 . TRP A 1 159 ? 1.02121   2.97804   15.16981 1.000 41.05607  ? 167 TRP A CZ3 1 
ATOM   1059 C CH2 . TRP A 1 159 ? -0.30800  2.76497   15.58853 1.000 46.32639  ? 167 TRP A CH2 1 
ATOM   1060 N N   . HIS A 1 160 ? 4.29898   2.14642   9.05892  1.000 52.17883  ? 168 HIS A N   1 
ATOM   1061 C CA  . HIS A 1 160 ? 5.67105   2.49186   8.70805  1.000 49.84650  ? 168 HIS A CA  1 
ATOM   1062 C C   . HIS A 1 160 ? 6.05013   3.78001   9.41803  1.000 48.72752  ? 168 HIS A C   1 
ATOM   1063 O O   . HIS A 1 160 ? 5.26312   4.72741   9.46593  1.000 50.15521  ? 168 HIS A O   1 
ATOM   1064 C CB  . HIS A 1 160 ? 5.84496   2.68981   7.20176  1.000 52.02529  ? 168 HIS A CB  1 
ATOM   1065 C CG  . HIS A 1 160 ? 5.50797   1.48729   6.37663  1.000 56.97173  ? 168 HIS A CG  1 
ATOM   1066 N ND1 . HIS A 1 160 ? 5.33472   1.55345   5.00966  1.000 60.39836  ? 168 HIS A ND1 1 
ATOM   1067 C CD2 . HIS A 1 160 ? 5.32523   0.18944   6.71624  1.000 58.06715  ? 168 HIS A CD2 1 
ATOM   1068 C CE1 . HIS A 1 160 ? 5.05929   0.34798   4.54291  1.000 61.30419  ? 168 HIS A CE1 1 
ATOM   1069 N NE2 . HIS A 1 160 ? 5.04719   -0.49797  5.55821  1.000 63.57614  ? 168 HIS A NE2 1 
ATOM   1070 N N   . GLY A 1 161 ? 7.24860   3.81098   9.98250  1.000 50.39840  ? 169 GLY A N   1 
ATOM   1071 C CA  . GLY A 1 161 ? 7.73547   5.04625   10.55831 1.000 50.92226  ? 169 GLY A CA  1 
ATOM   1072 C C   . GLY A 1 161 ? 8.31120   5.93499   9.47658  1.000 56.97608  ? 169 GLY A C   1 
ATOM   1073 O O   . GLY A 1 161 ? 9.22967   5.52520   8.76501  1.000 62.37248  ? 169 GLY A O   1 
ATOM   1074 N N   . GLU A 1 162 ? 7.79448   7.14857   9.33385  1.000 50.79615  ? 170 GLU A N   1 
ATOM   1075 C CA  . GLU A 1 162 ? 8.30043   8.09653   8.35066  1.000 53.13956  ? 170 GLU A CA  1 
ATOM   1076 C C   . GLU A 1 162 ? 9.19654   9.10891   9.03809  1.000 50.60789  ? 170 GLU A C   1 
ATOM   1077 O O   . GLU A 1 162 ? 8.79039   9.72247   10.02816 1.000 50.07183  ? 170 GLU A O   1 
ATOM   1078 C CB  . GLU A 1 162 ? 7.14633   8.81970   7.66557  1.000 60.87246  ? 170 GLU A CB  1 
ATOM   1079 C CG  . GLU A 1 162 ? 7.50645   9.65796   6.45825  1.000 65.40303  ? 170 GLU A CG  1 
ATOM   1080 C CD  . GLU A 1 162 ? 6.27114   10.07186  5.66894  1.000 75.39404  ? 170 GLU A CD  1 
ATOM   1081 O OE1 . GLU A 1 162 ? 6.00071   11.29558  5.58005  1.000 77.11242  ? 170 GLU A OE1 1 
ATOM   1082 O OE2 . GLU A 1 162 ? 5.56441   9.16538   5.16095  1.000 74.83590  ? 170 GLU A OE2 1 
ATOM   1083 N N   . VAL A 1 163 ? 10.40872  9.28795   8.51814  1.000 52.73982  ? 171 VAL A N   1 
ATOM   1084 C CA  . VAL A 1 163 ? 11.27456  10.31543  9.07957  1.000 50.07074  ? 171 VAL A CA  1 
ATOM   1085 C C   . VAL A 1 163 ? 10.63904  11.66445  8.80788  1.000 51.66897  ? 171 VAL A C   1 
ATOM   1086 O O   . VAL A 1 163 ? 10.39876  12.03419  7.65424  1.000 57.03169  ? 171 VAL A O   1 
ATOM   1087 C CB  . VAL A 1 163 ? 12.69349  10.24599  8.50669  1.000 58.80382  ? 171 VAL A CB  1 
ATOM   1088 C CG1 . VAL A 1 163 ? 13.57050  11.32835  9.16699  1.000 53.35523  ? 171 VAL A CG1 1 
ATOM   1089 C CG2 . VAL A 1 163 ? 13.29253  8.85885   8.73140  1.000 59.48300  ? 171 VAL A CG2 1 
ATOM   1090 N N   . LEU A 1 164 ? 10.35102  12.39708  9.87622  1.000 47.99444  ? 172 LEU A N   1 
ATOM   1091 C CA  . LEU A 1 164 ? 9.60309   13.63480  9.79020  1.000 48.60467  ? 172 LEU A CA  1 
ATOM   1092 C C   . LEU A 1 164 ? 10.41199  14.83563  10.25619 1.000 51.06629  ? 172 LEU A C   1 
ATOM   1093 O O   . LEU A 1 164 ? 10.09236  15.96074  9.86502  1.000 49.56916  ? 172 LEU A O   1 
ATOM   1094 C CB  . LEU A 1 164 ? 8.31284   13.51065  10.61525 1.000 44.14151  ? 172 LEU A CB  1 
ATOM   1095 C CG  . LEU A 1 164 ? 7.50047   14.71154  11.07402 1.000 52.28187  ? 172 LEU A CG  1 
ATOM   1096 C CD1 . LEU A 1 164 ? 6.67221   15.21670  9.89482  1.000 55.77334  ? 172 LEU A CD1 1 
ATOM   1097 C CD2 . LEU A 1 164 ? 6.59627   14.35845  12.26873 1.000 44.90334  ? 172 LEU A CD2 1 
ATOM   1098 N N   . ALA A 1 165 ? 11.48162  14.61837  11.02236 1.000 45.15023  ? 173 ALA A N   1 
ATOM   1099 C CA  . ALA A 1 165 ? 12.35843  15.67611  11.49041 1.000 40.17934  ? 173 ALA A CA  1 
ATOM   1100 C C   . ALA A 1 165 ? 13.65778  15.04934  11.96910 1.000 47.66340  ? 173 ALA A C   1 
ATOM   1101 O O   . ALA A 1 165 ? 13.69761  13.88220  12.36857 1.000 44.32464  ? 173 ALA A O   1 
ATOM   1102 C CB  . ALA A 1 165 ? 11.72538  16.48049  12.62109 1.000 42.19246  ? 173 ALA A CB  1 
ATOM   1103 N N   . GLU A 1 166 ? 14.71850  15.83879  11.92473 1.000 47.26981  ? 174 GLU A N   1 
ATOM   1104 C CA  . GLU A 1 166 ? 16.03052  15.39079  12.34585 1.000 44.02939  ? 174 GLU A CA  1 
ATOM   1105 C C   . GLU A 1 166 ? 16.74808  16.54194  13.03105 1.000 45.13200  ? 174 GLU A C   1 
ATOM   1106 O O   . GLU A 1 166 ? 16.69861  17.67917  12.56110 1.000 49.69356  ? 174 GLU A O   1 
ATOM   1107 C CB  . GLU A 1 166 ? 16.85523  14.86302  11.15645 1.000 43.76167  ? 174 GLU A CB  1 
ATOM   1108 C CG  . GLU A 1 166 ? 18.34632  14.76211  11.50640 1.000 59.55492  ? 174 GLU A CG  1 
ATOM   1109 C CD  . GLU A 1 166 ? 19.08966  13.63832  10.79202 1.000 65.55200  ? 174 GLU A CD  1 
ATOM   1110 O OE1 . GLU A 1 166 ? 20.12950  13.19164  11.33576 1.000 66.67082  ? 174 GLU A OE1 1 
ATOM   1111 O OE2 . GLU A 1 166 ? 18.64562  13.21145  9.70506  1.000 70.65812  ? 174 GLU A OE2 1 
ATOM   1112 N N   . SER A 1 167 ? 17.37432  16.24866  14.16376 1.000 43.42995  ? 175 SER A N   1 
ATOM   1113 C CA  . SER A 1 167 ? 18.32381  17.14359  14.80603 1.000 42.40711  ? 175 SER A CA  1 
ATOM   1114 C C   . SER A 1 167 ? 19.61711  16.35149  14.97870 1.000 48.17490  ? 175 SER A C   1 
ATOM   1115 O O   . SER A 1 167 ? 19.57317  15.17587  15.36247 1.000 45.19784  ? 175 SER A O   1 
ATOM   1116 C CB  . SER A 1 167 ? 17.80505  17.66733  16.14269 1.000 41.04384  ? 175 SER A CB  1 
ATOM   1117 O OG  . SER A 1 167 ? 18.62075  18.72924  16.61483 1.000 40.14586  ? 175 SER A OG  1 
ATOM   1118 N N   . LYS A 1 168 ? 20.75663  16.98530  14.68066 1.000 45.81752  ? 176 LYS A N   1 
ATOM   1119 C CA  . LYS A 1 168 ? 22.03047  16.28016  14.61959 1.000 51.10380  ? 176 LYS A CA  1 
ATOM   1120 C C   . LYS A 1 168 ? 23.16399  17.27731  14.80741 1.000 51.85512  ? 176 LYS A C   1 
ATOM   1121 O O   . LYS A 1 168 ? 23.00376  18.47250  14.55128 1.000 52.05125  ? 176 LYS A O   1 
ATOM   1122 C CB  . LYS A 1 168 ? 22.19011  15.51692  13.28177 1.000 53.47956  ? 176 LYS A CB  1 
ATOM   1123 C CG  . LYS A 1 168 ? 22.19065  16.32531  11.93487 1.000 58.95709  ? 176 LYS A CG  1 
ATOM   1124 C CD  . LYS A 1 168 ? 23.45377  17.18578  11.71793 1.000 67.01026  ? 176 LYS A CD  1 
ATOM   1125 C CE  . LYS A 1 168 ? 23.27950  18.43455  10.86415 1.000 71.59582  ? 176 LYS A CE  1 
ATOM   1126 N NZ  . LYS A 1 168 ? 24.57867  19.20827  10.93111 1.000 74.19981  ? 176 LYS A NZ  1 
ATOM   1127 N N   . ARG A 1 169 ? 24.27736  16.79879  15.35304 1.000 54.43937  ? 177 ARG A N   1 
ATOM   1128 C CA  . ARG A 1 169 ? 25.46661  17.64555  15.41673 1.000 62.23939  ? 177 ARG A CA  1 
ATOM   1129 C C   . ARG A 1 169 ? 26.07217  17.83774  14.02192 1.000 66.88872  ? 177 ARG A C   1 
ATOM   1130 O O   . ARG A 1 169 ? 25.90759  17.00626  13.12224 1.000 70.02703  ? 177 ARG A O   1 
ATOM   1131 C CB  . ARG A 1 169 ? 26.52376  17.04182  16.32252 1.000 65.40788  ? 177 ARG A CB  1 
ATOM   1132 C CG  . ARG A 1 169 ? 26.52906  17.49580  17.76162 1.000 59.01891  ? 177 ARG A CG  1 
ATOM   1133 C CD  . ARG A 1 169 ? 27.92204  17.21921  18.34489 1.000 67.95427  ? 177 ARG A CD  1 
ATOM   1134 N NE  . ARG A 1 169 ? 28.44960  15.91859  17.93408 1.000 66.18306  ? 177 ARG A NE  1 
ATOM   1135 C CZ  . ARG A 1 169 ? 29.27043  15.71995  16.90855 1.000 69.60485  ? 177 ARG A CZ  1 
ATOM   1136 N NH1 . ARG A 1 169 ? 29.67163  16.72230  16.13972 1.000 72.85510  ? 177 ARG A NH1 1 
ATOM   1137 N NH2 . ARG A 1 169 ? 29.66731  14.48032  16.62585 1.000 66.77228  ? 177 ARG A NH2 1 
ATOM   1138 N N   . GLY A 1 170 ? 26.84641  18.90826  13.86746 1.000 67.75568  ? 178 GLY A N   1 
ATOM   1139 C CA  . GLY A 1 170 ? 27.53149  19.14319  12.60683 1.000 74.28910  ? 178 GLY A CA  1 
ATOM   1140 C C   . GLY A 1 170 ? 28.55230  18.07433  12.25125 1.000 78.76257  ? 178 GLY A C   1 
ATOM   1141 O O   . GLY A 1 170 ? 29.33717  17.66039  13.11157 1.000 76.92925  ? 178 GLY A O   1 
ATOM   1142 N N   . GLY A 1 171 ? 28.55139  17.62607  10.98820 1.000 85.73183  ? 179 GLY A N   1 
ATOM   1143 C CA  . GLY A 1 171 ? 29.53410  16.68600  10.45732 1.000 88.31166  ? 179 GLY A CA  1 
ATOM   1144 C C   . GLY A 1 171 ? 29.39865  15.27962  11.00885 1.000 88.58052  ? 179 GLY A C   1 
ATOM   1145 O O   . GLY A 1 171 ? 30.00165  14.96438  12.03986 1.000 86.73546  ? 179 GLY A O   1 
ATOM   1146 N N   . MET A 1 172 ? 28.63433  14.41671  10.33141 1.000 92.00415  ? 180 MET A N   1 
ATOM   1147 C CA  . MET A 1 172 ? 28.12571  13.20207  10.95911 1.000 97.73799  ? 180 MET A CA  1 
ATOM   1148 C C   . MET A 1 172 ? 28.58189  11.90648  10.28650 1.000 101.72962 ? 180 MET A C   1 
ATOM   1149 O O   . MET A 1 172 ? 28.77365  11.83390  9.06762  1.000 101.46880 ? 180 MET A O   1 
ATOM   1150 C CB  . MET A 1 172 ? 26.58338  13.23469  11.03187 1.000 95.14241  ? 180 MET A CB  1 
ATOM   1151 C CG  . MET A 1 172 ? 26.05398  12.78718  12.39754 1.000 92.70889  ? 180 MET A CG  1 
ATOM   1152 S SD  . MET A 1 172 ? 26.70630  13.73320  13.79947 1.000 87.85881  ? 180 MET A SD  1 
ATOM   1153 C CE  . MET A 1 172 ? 27.55443  12.42627  14.68225 1.000 71.50204  ? 180 MET A CE  1 
ATOM   1154 N N   . ASP A 1 173 ? 28.72804  10.87625  11.13172 1.000 100.88155 ? 181 ASP A N   1 
ATOM   1155 C CA  . ASP A 1 173 ? 28.95394  9.50264   10.68393 1.000 98.29611  ? 181 ASP A CA  1 
ATOM   1156 C C   . ASP A 1 173 ? 27.67301  8.88258   10.13569 1.000 101.86420 ? 181 ASP A C   1 
ATOM   1157 O O   . ASP A 1 173 ? 27.64275  8.39194   8.99904  1.000 103.56772 ? 181 ASP A O   1 
ATOM   1158 C CB  . ASP A 1 173 ? 29.49677  8.67837   11.85961 1.000 94.05003  ? 181 ASP A CB  1 
ATOM   1159 C CG  . ASP A 1 173 ? 29.81819  7.22706   11.49901 1.000 96.05650  ? 181 ASP A CG  1 
ATOM   1160 O OD1 . ASP A 1 173 ? 29.00867  6.55882   10.81342 1.000 96.58594  ? 181 ASP A OD1 1 
ATOM   1161 O OD2 . ASP A 1 173 ? 30.88627  6.74531   11.93575 1.000 91.35478  ? 181 ASP A OD2 1 
ATOM   1162 N N   . GLY A 1 174 ? 26.59891  8.90347   10.92339 1.000 99.65239  ? 182 GLY A N   1 
ATOM   1163 C CA  . GLY A 1 174 ? 25.34319  8.35065   10.45999 1.000 95.94426  ? 182 GLY A CA  1 
ATOM   1164 C C   . GLY A 1 174 ? 24.58504  9.25665   9.51344  1.000 99.97773  ? 182 GLY A C   1 
ATOM   1165 O O   . GLY A 1 174 ? 23.35705  9.35515   9.60951  1.000 98.34258  ? 182 GLY A O   1 
ATOM   1166 N N   . PHE A 1 175 ? 25.32248  9.88662   8.58293  1.000 101.25385 ? 183 PHE A N   1 
ATOM   1167 C CA  . PHE A 1 175 ? 24.84811  10.75885  7.50294  1.000 101.21525 ? 183 PHE A CA  1 
ATOM   1168 C C   . PHE A 1 175 ? 23.41939  11.27883  7.67302  1.000 100.61790 ? 183 PHE A C   1 
ATOM   1169 O O   . PHE A 1 175 ? 23.08718  11.86502  8.71112  1.000 99.14909  ? 183 PHE A O   1 
ATOM   1170 C CB  . PHE A 1 175 ? 24.98956  10.01040  6.16680  1.000 100.77020 ? 183 PHE A CB  1 
ATOM   1171 C CG  . PHE A 1 175 ? 24.44567  8.59565   6.19058  1.000 101.91510 ? 183 PHE A CG  1 
ATOM   1172 C CD1 . PHE A 1 175 ? 25.23664  7.54150   6.62674  1.000 100.52366 ? 183 PHE A CD1 1 
ATOM   1173 C CD2 . PHE A 1 175 ? 23.14795  8.31956   5.76666  1.000 100.02612 ? 183 PHE A CD2 1 
ATOM   1174 C CE1 . PHE A 1 175 ? 24.74009  6.24571   6.65235  1.000 102.81452 ? 183 PHE A CE1 1 
ATOM   1175 C CE2 . PHE A 1 175 ? 22.64055  7.02278   5.79084  1.000 99.62353  ? 183 PHE A CE2 1 
ATOM   1176 C CZ  . PHE A 1 175 ? 23.43995  5.98517   6.23093  1.000 100.65574 ? 183 PHE A CZ  1 
ATOM   1177 N N   . LEU A 1 176 ? 22.58681  11.12231  6.63852  1.000 97.37276  ? 184 LEU A N   1 
ATOM   1178 C CA  . LEU A 1 176 ? 21.13784  11.32127  6.74067  1.000 95.98018  ? 184 LEU A CA  1 
ATOM   1179 C C   . LEU A 1 176 ? 20.51626  9.92742   6.74240  1.000 95.78865  ? 184 LEU A C   1 
ATOM   1180 O O   . LEU A 1 176 ? 20.16442  9.37772   5.69254  1.000 92.80682  ? 184 LEU A O   1 
ATOM   1181 C CB  . LEU A 1 176 ? 20.56951  12.18640  5.61338  1.000 92.77188  ? 184 LEU A CB  1 
ATOM   1182 C CG  . LEU A 1 176 ? 20.76641  13.70843  5.61865  1.000 92.70604  ? 184 LEU A CG  1 
ATOM   1183 C CD1 . LEU A 1 176 ? 20.15187  14.32082  4.36560  1.000 88.18826  ? 184 LEU A CD1 1 
ATOM   1184 C CD2 . LEU A 1 176 ? 20.17221  14.34347  6.87180  1.000 88.29419  ? 184 LEU A CD2 1 
ATOM   1185 N N   . GLY A 1 177 ? 20.35194  9.36589   7.94221  1.000 93.69587  ? 185 GLY A N   1 
ATOM   1186 C CA  . GLY A 1 177 ? 19.79458  8.03512   8.08867  1.000 90.92887  ? 185 GLY A CA  1 
ATOM   1187 C C   . GLY A 1 177 ? 18.28044  8.09669   8.04634  1.000 84.48681  ? 185 GLY A C   1 
ATOM   1188 O O   . GLY A 1 177 ? 17.56870  7.52886   8.88662  1.000 80.14937  ? 185 GLY A O   1 
ATOM   1189 N N   . MET A 1 178 ? 17.80061  8.79570   7.01664  1.000 82.03995  ? 186 MET A N   1 
ATOM   1190 C CA  . MET A 1 178 ? 16.41101  9.12503   6.77607  1.000 78.15995  ? 186 MET A CA  1 
ATOM   1191 C C   . MET A 1 178 ? 15.64865  7.95420   6.17143  1.000 70.64017  ? 186 MET A C   1 
ATOM   1192 O O   . MET A 1 178 ? 14.50890  8.11899   5.73340  1.000 71.16077  ? 186 MET A O   1 
ATOM   1193 C CB  . MET A 1 178 ? 16.37106  10.35380  5.85210  1.000 80.61238  ? 186 MET A CB  1 
ATOM   1194 C CG  . MET A 1 178 ? 15.01645  10.96595  5.53391  1.000 79.48139  ? 186 MET A CG  1 
ATOM   1195 S SD  . MET A 1 178 ? 15.24847  12.58909  4.76870  1.000 96.67739  ? 186 MET A SD  1 
ATOM   1196 C CE  . MET A 1 178 ? 16.33528  13.42470  5.91354  1.000 81.92246  ? 186 MET A CE  1 
ATOM   1197 N N   . HIS A 1 179 ? 16.21924  6.75671   6.17577  1.000 70.33678  ? 187 HIS A N   1 
ATOM   1198 C CA  . HIS A 1 179 ? 15.45781  5.59621   5.74266  1.000 69.79145  ? 187 HIS A CA  1 
ATOM   1199 C C   . HIS A 1 179 ? 14.31487  5.32043   6.70176  1.000 67.38459  ? 187 HIS A C   1 
ATOM   1200 O O   . HIS A 1 179 ? 14.46130  5.42247   7.92462  1.000 63.92607  ? 187 HIS A O   1 
ATOM   1201 C CB  . HIS A 1 179 ? 16.32378  4.33932   5.63405  1.000 68.60301  ? 187 HIS A CB  1 
ATOM   1202 C CG  . HIS A 1 179 ? 17.12464  4.25355   4.37573  1.000 71.17567  ? 187 HIS A CG  1 
ATOM   1203 N ND1 . HIS A 1 179 ? 17.57124  3.05194   3.86731  1.000 71.09804  ? 187 HIS A ND1 1 
ATOM   1204 C CD2 . HIS A 1 179 ? 17.56266  5.21167   3.52362  1.000 72.99887  ? 187 HIS A CD2 1 
ATOM   1205 C CE1 . HIS A 1 179 ? 18.25238  3.27358   2.75612  1.000 70.71190  ? 187 HIS A CE1 1 
ATOM   1206 N NE2 . HIS A 1 179 ? 18.26566  4.57603   2.52762  1.000 73.98360  ? 187 HIS A NE2 1 
ATOM   1207 N N   . PHE A 1 180 ? 13.16791  4.99287   6.13080  1.000 65.04001  ? 188 PHE A N   1 
ATOM   1208 C CA  . PHE A 1 180 ? 12.01853  4.66653   6.94071  1.000 64.34856  ? 188 PHE A CA  1 
ATOM   1209 C C   . PHE A 1 180 ? 12.26462  3.32678   7.63902  1.000 66.69130  ? 188 PHE A C   1 
ATOM   1210 O O   . PHE A 1 180 ? 12.96454  2.46033   7.09798  1.000 66.13554  ? 188 PHE A O   1 
ATOM   1211 C CB  . PHE A 1 180 ? 10.75810  4.58178   6.07398  1.000 65.83727  ? 188 PHE A CB  1 
ATOM   1212 C CG  . PHE A 1 180 ? 10.35048  5.89900   5.42310  1.000 73.22620  ? 188 PHE A CG  1 
ATOM   1213 C CD1 . PHE A 1 180 ? 11.01630  7.09588   5.71519  1.000 70.29375  ? 188 PHE A CD1 1 
ATOM   1214 C CD2 . PHE A 1 180 ? 9.28217   5.93651   4.52396  1.000 73.14272  ? 188 PHE A CD2 1 
ATOM   1215 C CE1 . PHE A 1 180 ? 10.62609  8.29224   5.11672  1.000 67.69572  ? 188 PHE A CE1 1 
ATOM   1216 C CE2 . PHE A 1 180 ? 8.89145   7.12922   3.92104  1.000 71.98122  ? 188 PHE A CE2 1 
ATOM   1217 C CZ  . PHE A 1 180 ? 9.56200   8.30501   4.21385  1.000 68.99212  ? 188 PHE A CZ  1 
ATOM   1218 N N   . PRO A 1 181 ? 11.80750  3.16874   8.88274  1.000 62.37525  ? 189 PRO A N   1 
ATOM   1219 C CA  . PRO A 1 181 ? 11.65462  1.82502   9.44275  1.000 61.02508  ? 189 PRO A CA  1 
ATOM   1220 C C   . PRO A 1 181 ? 10.39724  1.22062   8.85096  1.000 61.75414  ? 189 PRO A C   1 
ATOM   1221 O O   . PRO A 1 181 ? 9.30378   1.36551   9.40614  1.000 56.65731  ? 189 PRO A O   1 
ATOM   1222 C CB  . PRO A 1 181 ? 11.54546  2.07092   10.95308 1.000 54.50810  ? 189 PRO A CB  1 
ATOM   1223 C CG  . PRO A 1 181 ? 10.99161  3.41767   11.05809 1.000 59.63560  ? 189 PRO A CG  1 
ATOM   1224 C CD  . PRO A 1 181 ? 11.57600  4.19931   9.90120  1.000 64.43094  ? 189 PRO A CD  1 
ATOM   1225 N N   . ALA A 1 182 ? 10.57178  0.47457   7.75987  1.000 69.07709  ? 190 ALA A N   1 
ATOM   1226 C CA  . ALA A 1 182 ? 9.50389   0.17188   6.82041  1.000 67.09146  ? 190 ALA A CA  1 
ATOM   1227 C C   . ALA A 1 182 ? 8.65954   -1.03074  7.21092  1.000 68.71971  ? 190 ALA A C   1 
ATOM   1228 O O   . ALA A 1 182 ? 7.97714   -1.00405  8.24114  1.000 67.90118  ? 190 ALA A O   1 
ATOM   1229 C CB  . ALA A 1 182 ? 10.14431  -0.08952  5.45719  1.000 69.86497  ? 190 ALA A CB  1 
ATOM   1230 N N   . THR A 1 183 ? 8.71757   -2.10868  6.42413  1.000 75.62007  ? 191 THR A N   1 
ATOM   1231 C CA  . THR A 1 183 ? 8.10105   -3.37271  6.83441  1.000 80.66595  ? 191 THR A CA  1 
ATOM   1232 C C   . THR A 1 183 ? 8.96373   -3.84038  8.00250  1.000 78.16460  ? 191 THR A C   1 
ATOM   1233 O O   . THR A 1 183 ? 9.79760   -4.74731  7.90276  1.000 73.53977  ? 191 THR A O   1 
ATOM   1234 C CB  . THR A 1 183 ? 8.01961   -4.37842  5.68286  1.000 83.38505  ? 191 THR A CB  1 
ATOM   1235 O OG1 . THR A 1 183 ? 9.24503   -4.37418  4.93571  1.000 83.25524  ? 191 THR A OG1 1 
ATOM   1236 C CG2 . THR A 1 183 ? 6.83853   -4.05809  4.75540  1.000 79.86798  ? 191 THR A CG2 1 
ATOM   1237 N N   . ASP A 1 184 ? 8.74517   -3.18934  9.14541  1.000 67.01453  ? 192 ASP A N   1 
ATOM   1238 C CA  . ASP A 1 184 ? 9.83967   -3.04347  10.07955 1.000 59.26060  ? 192 ASP A CA  1 
ATOM   1239 C C   . ASP A 1 184 ? 9.46219   -3.37899  11.50135 1.000 50.12004  ? 192 ASP A C   1 
ATOM   1240 O O   . ASP A 1 184 ? 9.68704   -4.50393  11.95833 1.000 51.45823  ? 192 ASP A O   1 
ATOM   1241 C CB  . ASP A 1 184 ? 10.34256  -1.60558  10.00995 1.000 63.25346  ? 192 ASP A CB  1 
ATOM   1242 C CG  . ASP A 1 184 ? 11.85838  -1.46957  10.21471 1.000 56.44369  ? 192 ASP A CG  1 
ATOM   1243 O OD1 . ASP A 1 184 ? 12.34510  -1.70966  11.33866 1.000 54.31449  ? 192 ASP A OD1 1 
ATOM   1244 O OD2 . ASP A 1 184 ? 12.55849  -1.12300  9.23524  1.000 60.00058  ? 192 ASP A OD2 1 
ATOM   1245 N N   . ILE A 1 185 ? 8.96399   -2.38847  12.22640 1.000 45.97211  ? 193 ILE A N   1 
ATOM   1246 C CA  . ILE A 1 185 ? 8.89114   -2.51787  13.67570 1.000 44.24510  ? 193 ILE A CA  1 
ATOM   1247 C C   . ILE A 1 185 ? 7.73088   -3.45092  13.98966 1.000 41.85430  ? 193 ILE A C   1 
ATOM   1248 O O   . ILE A 1 185 ? 6.56471   -3.11618  13.71134 1.000 43.05104  ? 193 ILE A O   1 
ATOM   1249 C CB  . ILE A 1 185 ? 8.77832   -1.14499  14.35583 1.000 42.29135  ? 193 ILE A CB  1 
ATOM   1250 C CG1 . ILE A 1 185 ? 9.96268   -0.27134  13.92693 1.000 43.00073  ? 193 ILE A CG1 1 
ATOM   1251 C CG2 . ILE A 1 185 ? 8.75866   -1.29830  15.86120 1.000 37.89978  ? 193 ILE A CG2 1 
ATOM   1252 C CD1 . ILE A 1 185 ? 9.97541   1.07289   14.56125 1.000 39.38080  ? 193 ILE A CD1 1 
ATOM   1253 N N   . PRO A 1 186 ? 8.01440   -4.63351  14.53306 1.000 41.09254  ? 194 PRO A N   1 
ATOM   1254 C CA  . PRO A 1 186 ? 6.96267   -5.63596  14.74309 1.000 43.28674  ? 194 PRO A CA  1 
ATOM   1255 C C   . PRO A 1 186 ? 5.93416   -5.16368  15.76370 1.000 41.93868  ? 194 PRO A C   1 
ATOM   1256 O O   . PRO A 1 186 ? 6.20659   -4.32020  16.62506 1.000 39.18905  ? 194 PRO A O   1 
ATOM   1257 C CB  . PRO A 1 186 ? 7.74187   -6.84506  15.26895 1.000 45.75626  ? 194 PRO A CB  1 
ATOM   1258 C CG  . PRO A 1 186 ? 8.92193   -6.23991  15.95351 1.000 43.60468  ? 194 PRO A CG  1 
ATOM   1259 C CD  . PRO A 1 186 ? 9.29299   -5.03394  15.14499 1.000 42.63296  ? 194 PRO A CD  1 
ATOM   1260 N N   . VAL A 1 187 ? 4.74889   -5.77624  15.69333 1.000 40.93302  ? 195 VAL A N   1 
ATOM   1261 C CA  . VAL A 1 187 ? 3.62982   -5.34278  16.52141 1.000 36.77114  ? 195 VAL A CA  1 
ATOM   1262 C C   . VAL A 1 187 ? 3.98307   -5.41538  18.00527 1.000 35.04055  ? 195 VAL A C   1 
ATOM   1263 O O   . VAL A 1 187 ? 3.59968   -4.53990  18.78982 1.000 32.22428  ? 195 VAL A O   1 
ATOM   1264 C CB  . VAL A 1 187 ? 2.35857   -6.15724  16.17909 1.000 41.78828  ? 195 VAL A CB  1 
ATOM   1265 C CG1 . VAL A 1 187 ? 2.44904   -7.60526  16.67342 1.000 41.13097  ? 195 VAL A CG1 1 
ATOM   1266 C CG2 . VAL A 1 187 ? 1.16900   -5.49027  16.77323 1.000 41.57338  ? 195 VAL A CG2 1 
ATOM   1267 N N   . GLN A 1 188 ? 4.75007   -6.42725  18.41209 1.000 35.10935  ? 196 GLN A N   1 
ATOM   1268 C CA  . GLN A 1 188 ? 5.08644   -6.55547  19.82704 1.000 39.18333  ? 196 GLN A CA  1 
ATOM   1269 C C   . GLN A 1 188 ? 5.95835   -5.40070  20.29798 1.000 40.80624  ? 196 GLN A C   1 
ATOM   1270 O O   . GLN A 1 188 ? 5.85895   -4.98470  21.45890 1.000 37.44828  ? 196 GLN A O   1 
ATOM   1271 C CB  . GLN A 1 188 ? 5.80295   -7.87812  20.07416 1.000 44.63781  ? 196 GLN A CB  1 
ATOM   1272 C CG  . GLN A 1 188 ? 4.96492   -9.11825  19.76811 1.000 48.84283  ? 196 GLN A CG  1 
ATOM   1273 C CD  . GLN A 1 188 ? 5.04340   -9.52704  18.29084 1.000 53.75714  ? 196 GLN A CD  1 
ATOM   1274 O OE1 . GLN A 1 188 ? 5.92512   -9.07019  17.54487 1.000 48.18750  ? 196 GLN A OE1 1 
ATOM   1275 N NE2 . GLN A 1 188 ? 4.16780   -10.45028 17.88552 1.000 51.95780  ? 196 GLN A NE2 1 
ATOM   1276 N N   . ALA A 1 189 ? 6.82960   -4.88895  19.41660 1.000 36.72678  ? 197 ALA A N   1 
ATOM   1277 C CA  . ALA A 1 189 ? 7.64739   -3.73758  19.77356 1.000 37.42318  ? 197 ALA A CA  1 
ATOM   1278 C C   . ALA A 1 189 ? 6.79369   -2.48352  19.88442 1.000 35.78203  ? 197 ALA A C   1 
ATOM   1279 O O   . ALA A 1 189 ? 6.91660   -1.73006  20.85491 1.000 34.68493  ? 197 ALA A O   1 
ATOM   1280 C CB  . ALA A 1 189 ? 8.77627   -3.55135  18.75708 1.000 33.74611  ? 197 ALA A CB  1 
ATOM   1281 N N   . ARG A 1 190 ? 5.88506   -2.27119  18.92604 1.000 35.76729  ? 198 ARG A N   1 
ATOM   1282 C CA  . ARG A 1 190 ? 4.97695   -1.12465  18.99786 1.000 36.90213  ? 198 ARG A CA  1 
ATOM   1283 C C   . ARG A 1 190 ? 4.03814   -1.21610  20.20117 1.000 35.03205  ? 198 ARG A C   1 
ATOM   1284 O O   . ARG A 1 190 ? 3.63753   -0.18461  20.75272 1.000 32.47113  ? 198 ARG A O   1 
ATOM   1285 C CB  . ARG A 1 190 ? 4.19355   -1.01115  17.69140 1.000 33.92227  ? 198 ARG A CB  1 
ATOM   1286 C CG  . ARG A 1 190 ? 5.03405   -0.41456  16.54840 1.000 32.05488  ? 198 ARG A CG  1 
ATOM   1287 C CD  . ARG A 1 190 ? 4.29816   -0.43527  15.18405 1.000 39.43702  ? 198 ARG A CD  1 
ATOM   1288 N NE  . ARG A 1 190 ? 4.28729   -1.74826  14.54125 1.000 41.09007  ? 198 ARG A NE  1 
ATOM   1289 C CZ  . ARG A 1 190 ? 3.19733   -2.44526  14.24033 1.000 42.55172  ? 198 ARG A CZ  1 
ATOM   1290 N NH1 . ARG A 1 190 ? 1.98331   -2.00408  14.53352 1.000 35.67723  ? 198 ARG A NH1 1 
ATOM   1291 N NH2 . ARG A 1 190 ? 3.32839   -3.61472  13.61816 1.000 41.55757  ? 198 ARG A NH2 1 
ATOM   1292 N N   . ALA A 1 191 ? 3.70650   -2.43203  20.65343 1.000 32.41119  ? 199 ALA A N   1 
ATOM   1293 C CA  . ALA A 1 191 ? 2.87811   -2.54363  21.84985 1.000 34.15557  ? 199 ALA A CA  1 
ATOM   1294 C C   . ALA A 1 191 ? 3.65354   -2.12124  23.08652 1.000 35.52831  ? 199 ALA A C   1 
ATOM   1295 O O   . ALA A 1 191 ? 3.09447   -1.49436  23.99945 1.000 35.78735  ? 199 ALA A O   1 
ATOM   1296 C CB  . ALA A 1 191 ? 2.34659   -3.97024  22.01962 1.000 30.15630  ? 199 ALA A CB  1 
ATOM   1297 N N   . LEU A 1 192 ? 4.94424   -2.44484  23.13880 1.000 35.31945  ? 200 LEU A N   1 
ATOM   1298 C CA  . LEU A 1 192 ? 5.73856   -2.03217  24.29134 1.000 36.64835  ? 200 LEU A CA  1 
ATOM   1299 C C   . LEU A 1 192 ? 5.99376   -0.53437  24.27818 1.000 35.59112  ? 200 LEU A C   1 
ATOM   1300 O O   . LEU A 1 192 ? 6.04715   0.10672   25.33678 1.000 35.85044  ? 200 LEU A O   1 
ATOM   1301 C CB  . LEU A 1 192 ? 7.06539   -2.77757  24.31218 1.000 37.47287  ? 200 LEU A CB  1 
ATOM   1302 C CG  . LEU A 1 192 ? 6.99592   -4.26884  24.57213 1.000 40.89553  ? 200 LEU A CG  1 
ATOM   1303 C CD1 . LEU A 1 192 ? 8.43402   -4.74837  24.90523 1.000 40.81871  ? 200 LEU A CD1 1 
ATOM   1304 C CD2 . LEU A 1 192 ? 6.01176   -4.55869  25.70082 1.000 37.80296  ? 200 LEU A CD2 1 
ATOM   1305 N N   . TYR A 1 193 ? 6.16012   0.03421   23.08862 1.000 31.09670  ? 201 TYR A N   1 
ATOM   1306 C CA  . TYR A 1 193 ? 6.32554   1.47139   22.96703 1.000 33.13126  ? 201 TYR A CA  1 
ATOM   1307 C C   . TYR A 1 193 ? 5.07229   2.22214   23.41984 1.000 38.49859  ? 201 TYR A C   1 
ATOM   1308 O O   . TYR A 1 193 ? 5.16456   3.35926   23.90749 1.000 33.49032  ? 201 TYR A O   1 
ATOM   1309 C CB  . TYR A 1 193 ? 6.62009   1.82228   21.52226 1.000 37.65226  ? 201 TYR A CB  1 
ATOM   1310 C CG  . TYR A 1 193 ? 7.89856   1.24736   20.97163 1.000 41.32492  ? 201 TYR A CG  1 
ATOM   1311 C CD1 . TYR A 1 193 ? 8.19812   1.39773   19.62984 1.000 43.38277  ? 201 TYR A CD1 1 
ATOM   1312 C CD2 . TYR A 1 193 ? 8.78459   0.51929   21.77530 1.000 43.42586  ? 201 TYR A CD2 1 
ATOM   1313 C CE1 . TYR A 1 193 ? 9.33219   0.88659   19.09660 1.000 43.26744  ? 201 TYR A CE1 1 
ATOM   1314 C CE2 . TYR A 1 193 ? 9.92458   -0.02954  21.24026 1.000 50.43164  ? 201 TYR A CE2 1 
ATOM   1315 C CZ  . TYR A 1 193 ? 10.18627  0.17648   19.89625 1.000 51.31226  ? 201 TYR A CZ  1 
ATOM   1316 O OH  . TYR A 1 193 ? 11.32122  -0.30932  19.32473 1.000 54.74362  ? 201 TYR A OH  1 
ATOM   1317 N N   . THR A 1 194 ? 3.89273   1.61522   23.24238 1.000 34.21495  ? 202 THR A N   1 
ATOM   1318 C CA  . THR A 1 194 ? 2.65646   2.25683   23.67621 1.000 31.81751  ? 202 THR A CA  1 
ATOM   1319 C C   . THR A 1 194 ? 2.56123   2.25267   25.19085 1.000 32.49495  ? 202 THR A C   1 
ATOM   1320 O O   . THR A 1 194 ? 2.17325   3.25106   25.80173 1.000 36.58770  ? 202 THR A O   1 
ATOM   1321 C CB  . THR A 1 194 ? 1.45924   1.54513   23.03912 1.000 36.14236  ? 202 THR A CB  1 
ATOM   1322 O OG1 . THR A 1 194 ? 1.61719   1.53702   21.61383 1.000 33.33963  ? 202 THR A OG1 1 
ATOM   1323 C CG2 . THR A 1 194 ? 0.11298   2.24392   23.40114 1.000 37.03893  ? 202 THR A CG2 1 
ATOM   1324 N N   . ARG A 1 195 ? 2.97020   1.15954   25.81634 1.000 34.34597  ? 203 ARG A N   1 
ATOM   1325 C CA  . ARG A 1 195 ? 2.88077   1.02258   27.26258 1.000 35.74806  ? 203 ARG A CA  1 
ATOM   1326 C C   . ARG A 1 195 ? 4.02468   1.70024   28.01687 1.000 36.64197  ? 203 ARG A C   1 
ATOM   1327 O O   . ARG A 1 195 ? 3.89724   1.92158   29.22479 1.000 36.35705  ? 203 ARG A O   1 
ATOM   1328 C CB  . ARG A 1 195 ? 2.83597   -0.46335  27.62025 1.000 38.20816  ? 203 ARG A CB  1 
ATOM   1329 C CG  . ARG A 1 195 ? 1.61247   -1.23731  27.03851 1.000 43.78865  ? 203 ARG A CG  1 
ATOM   1330 C CD  . ARG A 1 195 ? 1.82189   -2.76006  27.18994 1.000 43.17535  ? 203 ARG A CD  1 
ATOM   1331 N NE  . ARG A 1 195 ? 1.85631   -3.16538  28.59391 1.000 46.14080  ? 203 ARG A NE  1 
ATOM   1332 C CZ  . ARG A 1 195 ? 1.99526   -4.41583  29.02154 1.000 44.35477  ? 203 ARG A CZ  1 
ATOM   1333 N NH1 . ARG A 1 195 ? 2.16190   -5.42216  28.17805 1.000 40.71613  ? 203 ARG A NH1 1 
ATOM   1334 N NH2 . ARG A 1 195 ? 1.93739   -4.66341  30.32812 1.000 40.84503  ? 203 ARG A NH2 1 
ATOM   1335 N N   . ASN A 1 196 ? 5.15489   1.99394   27.36820 1.000 39.20513  ? 204 ASN A N   1 
ATOM   1336 C CA  . ASN A 1 196 ? 6.27596   2.67362   28.03247 1.000 39.75238  ? 204 ASN A CA  1 
ATOM   1337 C C   . ASN A 1 196 ? 6.67774   3.91624   27.25719 1.000 37.09687  ? 204 ASN A C   1 
ATOM   1338 O O   . ASN A 1 196 ? 7.03462   3.81019   26.06896 1.000 37.53952  ? 204 ASN A O   1 
ATOM   1339 C CB  . ASN A 1 196 ? 7.48378   1.75478   28.17260 1.000 40.54478  ? 204 ASN A CB  1 
ATOM   1340 C CG  . ASN A 1 196 ? 7.10780   0.43364   28.72659 1.000 40.06648  ? 204 ASN A CG  1 
ATOM   1341 O OD1 . ASN A 1 196 ? 6.91718   0.28353   29.93517 1.000 43.03382  ? 204 ASN A OD1 1 
ATOM   1342 N ND2 . ASN A 1 196 ? 6.98384   -0.55036  27.84988 1.000 44.32095  ? 204 ASN A ND2 1 
ATOM   1343 N N   . PRO A 1 197 ? 6.67121   5.09263   27.88365 1.000 41.12063  ? 205 PRO A N   1 
ATOM   1344 C CA  . PRO A 1 197 ? 7.10882   6.30794   27.17729 1.000 41.50688  ? 205 PRO A CA  1 
ATOM   1345 C C   . PRO A 1 197 ? 8.60037   6.37107   26.87734 1.000 34.69700  ? 205 PRO A C   1 
ATOM   1346 O O   . PRO A 1 197 ? 8.97189   6.96443   25.85939 1.000 38.50407  ? 205 PRO A O   1 
ATOM   1347 C CB  . PRO A 1 197 ? 6.69549   7.43933   28.12889 1.000 42.93863  ? 205 PRO A CB  1 
ATOM   1348 C CG  . PRO A 1 197 ? 5.74622   6.81182   29.11131 1.000 49.44443  ? 205 PRO A CG  1 
ATOM   1349 C CD  . PRO A 1 197 ? 6.09843   5.37353   29.20586 1.000 41.17577  ? 205 PRO A CD  1 
ATOM   1350 N N   . LEU A 1 198 ? 9.46299   5.83023   27.73378 1.000 36.25074  ? 206 LEU A N   1 
ATOM   1351 C CA  . LEU A 1 198 ? 10.91385  5.95288   27.58043 1.000 37.81002  ? 206 LEU A CA  1 
ATOM   1352 C C   . LEU A 1 198 ? 11.56771  4.58541   27.47740 1.000 37.41726  ? 206 LEU A C   1 
ATOM   1353 O O   . LEU A 1 198 ? 11.23430  3.67296   28.23722 1.000 37.73220  ? 206 LEU A O   1 
ATOM   1354 C CB  . LEU A 1 198 ? 11.54833  6.68902   28.75917 1.000 35.01042  ? 206 LEU A CB  1 
ATOM   1355 C CG  . LEU A 1 198 ? 11.16297  8.13206   29.03514 1.000 40.07699  ? 206 LEU A CG  1 
ATOM   1356 C CD1 . LEU A 1 198 ? 12.11064  8.68718   30.09303 1.000 37.10402  ? 206 LEU A CD1 1 
ATOM   1357 C CD2 . LEU A 1 198 ? 11.17192  8.96273   27.75547 1.000 36.82987  ? 206 LEU A CD2 1 
ATOM   1358 N N   . ARG A 1 199 ? 12.52399  4.46040   26.55823 1.000 35.33419  ? 207 ARG A N   1 
ATOM   1359 C CA  . ARG A 1 199 ? 13.25973  3.21488   26.37407 1.000 38.38122  ? 207 ARG A CA  1 
ATOM   1360 C C   . ARG A 1 199 ? 14.74622  3.52352   26.18389 1.000 38.56179  ? 207 ARG A C   1 
ATOM   1361 O O   . ARG A 1 199 ? 15.10261  4.31173   25.30353 1.000 39.50731  ? 207 ARG A O   1 
ATOM   1362 C CB  . ARG A 1 199 ? 12.65962  2.44353   25.19089 1.000 38.06563  ? 207 ARG A CB  1 
ATOM   1363 C CG  . ARG A 1 199 ? 13.46959  1.28259   24.72201 1.000 44.83315  ? 207 ARG A CG  1 
ATOM   1364 C CD  . ARG A 1 199 ? 13.52767  0.27050   25.84129 1.000 46.47567  ? 207 ARG A CD  1 
ATOM   1365 N NE  . ARG A 1 199 ? 13.99712  -1.03668  25.41992 1.000 49.03084  ? 207 ARG A NE  1 
ATOM   1366 C CZ  . ARG A 1 199 ? 14.57594  -1.89332  26.24926 1.000 44.78280  ? 207 ARG A CZ  1 
ATOM   1367 N NH1 . ARG A 1 199 ? 14.81924  -1.57105  27.51317 1.000 40.62966  ? 207 ARG A NH1 1 
ATOM   1368 N NH2 . ARG A 1 199 ? 14.93777  -3.08983  25.79789 1.000 43.49257  ? 207 ARG A NH2 1 
ATOM   1369 N N   . LEU A 1 200 ? 15.61807  2.93658   27.01512 1.000 35.05859  ? 208 LEU A N   1 
ATOM   1370 C CA  . LEU A 1 200 ? 17.05213  3.19008   26.91829 1.000 38.28596  ? 208 LEU A CA  1 
ATOM   1371 C C   . LEU A 1 200 ? 17.84179  1.89497   26.70031 1.000 40.85095  ? 208 LEU A C   1 
ATOM   1372 O O   . LEU A 1 200 ? 17.76802  0.95848   27.51018 1.000 38.26822  ? 208 LEU A O   1 
ATOM   1373 C CB  . LEU A 1 200 ? 17.57008  3.92378   28.15822 1.000 32.63148  ? 208 LEU A CB  1 
ATOM   1374 C CG  . LEU A 1 200 ? 19.11613  3.94590   28.25181 1.000 39.06187  ? 208 LEU A CG  1 
ATOM   1375 C CD1 . LEU A 1 200 ? 19.72868  4.89705   27.22615 1.000 34.61382  ? 208 LEU A CD1 1 
ATOM   1376 C CD2 . LEU A 1 200 ? 19.59197  4.29736   29.64141 1.000 36.28994  ? 208 LEU A CD2 1 
ATOM   1377 N N   . ILE A 1 201 ? 18.62728  1.86887   25.62627 1.000 39.37891  ? 209 ILE A N   1 
ATOM   1378 C CA  . ILE A 1 201 ? 19.66308  0.86450   25.39893 1.000 39.00747  ? 209 ILE A CA  1 
ATOM   1379 C C   . ILE A 1 201 ? 20.99221  1.53656   25.72284 1.000 37.60655  ? 209 ILE A C   1 
ATOM   1380 O O   . ILE A 1 201 ? 21.47497  2.36981   24.95548 1.000 38.57487  ? 209 ILE A O   1 
ATOM   1381 C CB  . ILE A 1 201 ? 19.64113  0.32799   23.96778 1.000 37.81045  ? 209 ILE A CB  1 
ATOM   1382 C CG1 . ILE A 1 201 ? 18.23152  -0.10993  23.57046 1.000 37.85471  ? 209 ILE A CG1 1 
ATOM   1383 C CG2 . ILE A 1 201 ? 20.64551  -0.79836  23.81293 1.000 43.52529  ? 209 ILE A CG2 1 
ATOM   1384 C CD1 . ILE A 1 201 ? 18.08379  -0.41151  22.09958 1.000 40.08966  ? 209 ILE A CD1 1 
ATOM   1385 N N   . ALA A 1 202 ? 21.58528  1.21472   26.87956 1.000 34.45681  ? 210 ALA A N   1 
ATOM   1386 C CA  . ALA A 1 202 ? 22.75132  1.98761   27.30687 1.000 36.25545  ? 210 ALA A CA  1 
ATOM   1387 C C   . ALA A 1 202 ? 23.94128  1.79224   26.36721 1.000 38.45239  ? 210 ALA A C   1 
ATOM   1388 O O   . ALA A 1 202 ? 24.69362  2.74497   26.11881 1.000 37.05010  ? 210 ALA A O   1 
ATOM   1389 C CB  . ALA A 1 202 ? 23.13347  1.62924   28.74553 1.000 33.77571  ? 210 ALA A CB  1 
ATOM   1390 N N   . ASP A 1 203 ? 24.13494  0.57972   25.83823 1.000 33.40868  ? 211 ASP A N   1 
ATOM   1391 C CA  . ASP A 1 203 ? 25.29894  0.31604   24.98456 1.000 34.12843  ? 211 ASP A CA  1 
ATOM   1392 C C   . ASP A 1 203 ? 25.01206  -0.90026  24.11999 1.000 34.13178  ? 211 ASP A C   1 
ATOM   1393 O O   . ASP A 1 203 ? 24.91784  -2.02038  24.63709 1.000 33.85933  ? 211 ASP A O   1 
ATOM   1394 C CB  . ASP A 1 203 ? 26.56710  0.11710   25.81247 1.000 36.38287  ? 211 ASP A CB  1 
ATOM   1395 C CG  . ASP A 1 203 ? 27.84677  -0.08371  24.93455 1.000 40.08340  ? 211 ASP A CG  1 
ATOM   1396 O OD1 . ASP A 1 203 ? 27.78883  0.04644   23.66460 1.000 34.08731  ? 211 ASP A OD1 1 
ATOM   1397 O OD2 . ASP A 1 203 ? 28.93622  -0.23405  25.54630 1.000 35.87284  ? 211 ASP A OD2 1 
ATOM   1398 N N   . ALA A 1 204 ? 24.86041  -0.67365  22.80870 1.000 31.10905  ? 212 ALA A N   1 
ATOM   1399 C CA  . ALA A 1 204 ? 24.56377  -1.77778  21.90661 1.000 34.20880  ? 212 ALA A CA  1 
ATOM   1400 C C   . ALA A 1 204 ? 25.73119  -2.73516  21.73720 1.000 37.08493  ? 212 ALA A C   1 
ATOM   1401 O O   . ALA A 1 204 ? 25.53459  -3.81664  21.16955 1.000 34.65411  ? 212 ALA A O   1 
ATOM   1402 C CB  . ALA A 1 204 ? 24.15625  -1.24848  20.53268 1.000 33.34921  ? 212 ALA A CB  1 
ATOM   1403 N N   . ARG A 1 205 ? 26.93787  -2.37404  22.18489 1.000 34.56830  ? 213 ARG A N   1 
ATOM   1404 C CA  . ARG A 1 205 ? 28.02508  -3.35247  22.14823 1.000 38.69661  ? 213 ARG A CA  1 
ATOM   1405 C C   . ARG A 1 205 ? 28.08918  -4.19894  23.41473 1.000 38.14737  ? 213 ARG A C   1 
ATOM   1406 O O   . ARG A 1 205 ? 28.82076  -5.20400  23.44025 1.000 37.71860  ? 213 ARG A O   1 
ATOM   1407 C CB  . ARG A 1 205 ? 29.38743  -2.65601  21.91631 1.000 34.23078  ? 213 ARG A CB  1 
ATOM   1408 C CG  . ARG A 1 205 ? 29.68015  -2.31633  20.43918 1.000 38.32568  ? 213 ARG A CG  1 
ATOM   1409 C CD  . ARG A 1 205 ? 30.82731  -1.30624  20.26573 1.000 38.61658  ? 213 ARG A CD  1 
ATOM   1410 N NE  . ARG A 1 205 ? 31.97583  -1.62217  21.11006 1.000 39.48806  ? 213 ARG A NE  1 
ATOM   1411 C CZ  . ARG A 1 205 ? 33.13076  -0.96843  21.09257 1.000 42.17500  ? 213 ARG A CZ  1 
ATOM   1412 N NH1 . ARG A 1 205 ? 33.34565  0.03348   20.24731 1.000 43.10494  ? 213 ARG A NH1 1 
ATOM   1413 N NH2 . ARG A 1 205 ? 34.09373  -1.32512  21.94706 1.000 37.79079  ? 213 ARG A NH2 1 
ATOM   1414 N N   . ALA A 1 206 ? 27.36099  -3.81484  24.46439 1.000 32.49303  ? 214 ALA A N   1 
ATOM   1415 C CA  . ALA A 1 206 ? 27.37652  -4.59226  25.69372 1.000 35.20007  ? 214 ALA A CA  1 
ATOM   1416 C C   . ALA A 1 206 ? 26.58601  -5.89042  25.50346 1.000 33.91088  ? 214 ALA A C   1 
ATOM   1417 O O   . ALA A 1 206 ? 25.83847  -6.06235  24.53841 1.000 37.29816  ? 214 ALA A O   1 
ATOM   1418 C CB  . ALA A 1 206 ? 26.84429  -3.75984  26.86350 1.000 35.68619  ? 214 ALA A CB  1 
ATOM   1419 N N   . ARG A 1 207 ? 26.76912  -6.81968  26.43835 1.000 34.67546  ? 215 ARG A N   1 
ATOM   1420 C CA  . ARG A 1 207 ? 26.21411  -8.16847  26.35963 1.000 39.01507  ? 215 ARG A CA  1 
ATOM   1421 C C   . ARG A 1 207 ? 25.00683  -8.33340  27.28066 1.000 38.08262  ? 215 ARG A C   1 
ATOM   1422 O O   . ARG A 1 207 ? 25.03427  -7.87373  28.42933 1.000 40.24379  ? 215 ARG A O   1 
ATOM   1423 C CB  . ARG A 1 207 ? 27.27747  -9.19817  26.75186 1.000 42.63159  ? 215 ARG A CB  1 
ATOM   1424 C CG  . ARG A 1 207 ? 28.62584  -9.02831  26.05755 1.000 41.19817  ? 215 ARG A CG  1 
ATOM   1425 C CD  . ARG A 1 207 ? 28.67270  -9.84125  24.78664 1.000 43.86121  ? 215 ARG A CD  1 
ATOM   1426 N NE  . ARG A 1 207 ? 29.91609  -9.68928  24.03620 1.000 42.33394  ? 215 ARG A NE  1 
ATOM   1427 C CZ  . ARG A 1 207 ? 30.08612  -10.16978 22.81217 1.000 40.56808  ? 215 ARG A CZ  1 
ATOM   1428 N NH1 . ARG A 1 207 ? 29.15026  -10.89523 22.22473 1.000 37.64178  ? 215 ARG A NH1 1 
ATOM   1429 N NH2 . ARG A 1 207 ? 31.21554  -9.90437  22.15805 1.000 44.14861  ? 215 ARG A NH2 1 
ATOM   1430 N N   . PRO A 1 208 ? 23.92671  -8.98809  26.85947 1.000 35.59256  ? 216 PRO A N   1 
ATOM   1431 C CA  . PRO A 1 208 ? 22.80130  -9.18512  27.77527 1.000 40.24870  ? 216 PRO A CA  1 
ATOM   1432 C C   . PRO A 1 208 ? 23.17816  -10.13220 28.89924 1.000 40.07078  ? 216 PRO A C   1 
ATOM   1433 O O   . PRO A 1 208 ? 24.08136  -10.95981 28.76778 1.000 41.87359  ? 216 PRO A O   1 
ATOM   1434 C CB  . PRO A 1 208 ? 21.70663  -9.77420  26.88343 1.000 37.17090  ? 216 PRO A CB  1 
ATOM   1435 C CG  . PRO A 1 208 ? 22.42444  -10.37641 25.75832 1.000 43.70468  ? 216 PRO A CG  1 
ATOM   1436 C CD  . PRO A 1 208 ? 23.63990  -9.52051  25.52135 1.000 38.73565  ? 216 PRO A CD  1 
ATOM   1437 N N   . VAL A 1 209 ? 22.50892  -9.95604  30.03013 1.000 38.83433  ? 217 VAL A N   1 
ATOM   1438 C CA  . VAL A 1 209 ? 22.69292  -10.76538 31.22785 1.000 36.95648  ? 217 VAL A CA  1 
ATOM   1439 C C   . VAL A 1 209 ? 21.45235  -11.63037 31.41735 1.000 40.23094  ? 217 VAL A C   1 
ATOM   1440 O O   . VAL A 1 209 ? 20.33542  -11.09600 31.48911 1.000 40.07219  ? 217 VAL A O   1 
ATOM   1441 C CB  . VAL A 1 209 ? 22.94253  -9.89466  32.46203 1.000 36.63851  ? 217 VAL A CB  1 
ATOM   1442 C CG1 . VAL A 1 209 ? 22.98807  -10.76466 33.70731 1.000 37.88424  ? 217 VAL A CG1 1 
ATOM   1443 C CG2 . VAL A 1 209 ? 24.23127  -9.10520  32.28822 1.000 37.72163  ? 217 VAL A CG2 1 
ATOM   1444 N N   . PRO A 1 210 ? 21.59385  -12.94856 31.51178 1.000 40.50877  ? 218 PRO A N   1 
ATOM   1445 C CA  . PRO A 1 210 ? 20.41745  -13.80923 31.68359 1.000 39.01457  ? 218 PRO A CA  1 
ATOM   1446 C C   . PRO A 1 210 ? 19.80655  -13.65932 33.06980 1.000 41.07291  ? 218 PRO A C   1 
ATOM   1447 O O   . PRO A 1 210 ? 20.49958  -13.37907 34.05300 1.000 37.47350  ? 218 PRO A O   1 
ATOM   1448 C CB  . PRO A 1 210 ? 20.97402  -15.22733 31.47895 1.000 40.63129  ? 218 PRO A CB  1 
ATOM   1449 C CG  . PRO A 1 210 ? 22.46979  -15.08701 31.74015 1.000 39.77000  ? 218 PRO A CG  1 
ATOM   1450 C CD  . PRO A 1 210 ? 22.84140  -13.71091 31.30467 1.000 40.64605  ? 218 PRO A CD  1 
ATOM   1451 N N   . LEU A 1 211 ? 18.47841  -13.83335 33.12648 1.000 37.94199  ? 219 LEU A N   1 
ATOM   1452 C CA  . LEU A 1 211 ? 17.72549  -13.91101 34.37591 1.000 43.69043  ? 219 LEU A CA  1 
ATOM   1453 C C   . LEU A 1 211 ? 17.68889  -15.35710 34.87479 1.000 42.71152  ? 219 LEU A C   1 
ATOM   1454 O O   . LEU A 1 211 ? 17.62128  -16.29777 34.07786 1.000 43.65604  ? 219 LEU A O   1 
ATOM   1455 C CB  . LEU A 1 211 ? 16.28758  -13.38452 34.19253 1.000 41.61023  ? 219 LEU A CB  1 
ATOM   1456 C CG  . LEU A 1 211 ? 16.11083  -11.86986 33.99177 1.000 41.92914  ? 219 LEU A CG  1 
ATOM   1457 C CD1 . LEU A 1 211 ? 14.65664  -11.44114 33.75162 1.000 40.23764  ? 219 LEU A CD1 1 
ATOM   1458 C CD2 . LEU A 1 211 ? 16.69206  -11.11105 35.17278 1.000 40.24303  ? 219 LEU A CD2 1 
ATOM   1459 N N   . LEU A 1 212 ? 17.77478  -15.53004 36.19827 1.000 43.83866  ? 220 LEU A N   1 
ATOM   1460 C CA  . LEU A 1 212 ? 17.77293  -16.84558 36.83806 1.000 44.06928  ? 220 LEU A CA  1 
ATOM   1461 C C   . LEU A 1 212 ? 16.55410  -16.98420 37.74406 1.000 47.32553  ? 220 LEU A C   1 
ATOM   1462 O O   . LEU A 1 212 ? 16.26002  -16.05693 38.51407 1.000 48.95134  ? 220 LEU A O   1 
ATOM   1463 C CB  . LEU A 1 212 ? 19.04404  -17.04701 37.66107 1.000 44.23409  ? 220 LEU A CB  1 
ATOM   1464 C CG  . LEU A 1 212 ? 20.36580  -16.72011 36.95398 1.000 46.12716  ? 220 LEU A CG  1 
ATOM   1465 C CD1 . LEU A 1 212 ? 21.51508  -16.82090 37.94287 1.000 41.07269  ? 220 LEU A CD1 1 
ATOM   1466 C CD2 . LEU A 1 212 ? 20.59269  -17.64054 35.75039 1.000 46.08413  ? 220 LEU A CD2 1 
ATOM   1467 N N   . PRO A 1 213 ? 15.82815  -18.12285 37.70737 1.000 50.49111  ? 221 PRO A N   1 
ATOM   1468 C CA  . PRO A 1 213 ? 16.01841  -19.29066 36.82618 1.000 49.92964  ? 221 PRO A CA  1 
ATOM   1469 C C   . PRO A 1 213 ? 15.57223  -18.95189 35.40956 1.000 49.01261  ? 221 PRO A C   1 
ATOM   1470 O O   . PRO A 1 213 ? 14.84866  -17.97667 35.21654 1.000 46.45173  ? 221 PRO A O   1 
ATOM   1471 C CB  . PRO A 1 213 ? 15.12453  -20.37541 37.46862 1.000 51.79168  ? 221 PRO A CB  1 
ATOM   1472 C CG  . PRO A 1 213 ? 14.80727  -19.87776 38.85294 1.000 51.17398  ? 221 PRO A CG  1 
ATOM   1473 C CD  . PRO A 1 213 ? 14.78929  -18.38209 38.71898 1.000 48.96325  ? 221 PRO A CD  1 
ATOM   1474 N N   . PRO A 1 214 ? 15.99767  -19.73735 34.41681 1.000 49.19179  ? 222 PRO A N   1 
ATOM   1475 C CA  . PRO A 1 214 ? 15.64564  -19.41982 33.02193 1.000 49.88105  ? 222 PRO A CA  1 
ATOM   1476 C C   . PRO A 1 214 ? 14.15295  -19.34744 32.76906 1.000 51.36568  ? 222 PRO A C   1 
ATOM   1477 O O   . PRO A 1 214 ? 13.71801  -18.56537 31.91248 1.000 54.14406  ? 222 PRO A O   1 
ATOM   1478 C CB  . PRO A 1 214 ? 16.29864  -20.56014 32.23504 1.000 52.61198  ? 222 PRO A CB  1 
ATOM   1479 C CG  . PRO A 1 214 ? 17.46013  -20.97512 33.10354 1.000 52.03546  ? 222 PRO A CG  1 
ATOM   1480 C CD  . PRO A 1 214 ? 16.94605  -20.86018 34.50461 1.000 52.31736  ? 222 PRO A CD  1 
ATOM   1481 N N   . VAL A 1 215 ? 13.35021  -20.15487 33.45390 1.000 51.37291  ? 223 VAL A N   1 
ATOM   1482 C CA  . VAL A 1 215 ? 11.90315  -19.98309 33.44627 1.000 51.01483  ? 223 VAL A CA  1 
ATOM   1483 C C   . VAL A 1 215 ? 11.42486  -19.91297 34.88832 1.000 54.77739  ? 223 VAL A C   1 
ATOM   1484 O O   . VAL A 1 215 ? 11.93769  -20.62626 35.75930 1.000 57.14315  ? 223 VAL A O   1 
ATOM   1485 C CB  . VAL A 1 215 ? 11.18874  -21.10912 32.67537 1.000 53.57659  ? 223 VAL A CB  1 
ATOM   1486 C CG1 . VAL A 1 215 ? 11.58354  -21.06224 31.20172 1.000 52.12222  ? 223 VAL A CG1 1 
ATOM   1487 C CG2 . VAL A 1 215 ? 11.48928  -22.46988 33.28846 1.000 53.67547  ? 223 VAL A CG2 1 
ATOM   1488 N N   . VAL A 1 216 ? 10.45644  -19.03770 35.14204 1.000 49.31503  ? 224 VAL A N   1 
ATOM   1489 C CA  . VAL A 1 216 ? 9.90033   -18.85561 36.47824 1.000 56.93152  ? 224 VAL A CA  1 
ATOM   1490 C C   . VAL A 1 216 ? 9.01293   -20.05759 36.78265 1.000 60.95673  ? 224 VAL A C   1 
ATOM   1491 O O   . VAL A 1 216 ? 8.06751   -20.33378 36.02767 1.000 57.42708  ? 224 VAL A O   1 
ATOM   1492 C CB  . VAL A 1 216 ? 9.13300   -17.52784 36.59383 1.000 55.69251  ? 224 VAL A CB  1 
ATOM   1493 C CG1 . VAL A 1 216 ? 8.55125   -17.37055 37.98595 1.000 58.74604  ? 224 VAL A CG1 1 
ATOM   1494 C CG2 . VAL A 1 216 ? 10.06458  -16.34442 36.29195 1.000 46.83834  ? 224 VAL A CG2 1 
ATOM   1495 N N   . PRO A 1 217 ? 9.28670   -20.79750 37.86712 1.000 64.38707  ? 225 PRO A N   1 
ATOM   1496 C CA  . PRO A 1 217 ? 8.55887   -22.05715 38.09993 1.000 65.70616  ? 225 PRO A CA  1 
ATOM   1497 C C   . PRO A 1 217 ? 7.05335   -21.87729 38.10890 1.000 61.62309  ? 225 PRO A C   1 
ATOM   1498 O O   . PRO A 1 217 ? 6.33589   -22.66521 37.48759 1.000 62.16908  ? 225 PRO A O   1 
ATOM   1499 C CB  . PRO A 1 217 ? 9.09507   -22.51781 39.46320 1.000 64.75705  ? 225 PRO A CB  1 
ATOM   1500 C CG  . PRO A 1 217 ? 9.52887   -21.24638 40.14928 1.000 65.57779  ? 225 PRO A CG  1 
ATOM   1501 C CD  . PRO A 1 217 ? 10.06249  -20.37309 39.04980 1.000 63.33346  ? 225 PRO A CD  1 
ATOM   1502 N N   . ALA A 1 218 ? 6.56269   -20.83012 38.76977 1.000 60.25698  ? 226 ALA A N   1 
ATOM   1503 C CA  . ALA A 1 218 ? 5.13141   -20.57551 38.82012 1.000 63.32086  ? 226 ALA A CA  1 
ATOM   1504 C C   . ALA A 1 218 ? 4.53304   -20.30244 37.44740 1.000 62.56973  ? 226 ALA A C   1 
ATOM   1505 O O   . ALA A 1 218 ? 3.31904   -20.43299 37.28210 1.000 62.24726  ? 226 ALA A O   1 
ATOM   1506 C CB  . ALA A 1 218 ? 4.84462   -19.38734 39.74635 1.000 62.24485  ? 226 ALA A CB  1 
ATOM   1507 N N   . LEU A 1 219 ? 5.34334   -19.94581 36.45336 1.000 59.39656  ? 227 LEU A N   1 
ATOM   1508 C CA  . LEU A 1 219 ? 4.79444   -19.46722 35.19573 1.000 57.67883  ? 227 LEU A CA  1 
ATOM   1509 C C   . LEU A 1 219 ? 5.03956   -20.39460 34.02169 1.000 57.49826  ? 227 LEU A C   1 
ATOM   1510 O O   . LEU A 1 219 ? 4.27415   -20.35051 33.05166 1.000 54.92999  ? 227 LEU A O   1 
ATOM   1511 C CB  . LEU A 1 219 ? 5.37762   -18.08646 34.85558 1.000 58.18902  ? 227 LEU A CB  1 
ATOM   1512 C CG  . LEU A 1 219 ? 5.10264   -17.00839 35.89810 1.000 54.25747  ? 227 LEU A CG  1 
ATOM   1513 C CD1 . LEU A 1 219 ? 5.87891   -15.74877 35.56464 1.000 55.86338  ? 227 LEU A CD1 1 
ATOM   1514 C CD2 . LEU A 1 219 ? 3.60697   -16.73984 35.96451 1.000 55.24920  ? 227 LEU A CD2 1 
ATOM   1515 N N   . GLY A 1 220 ? 6.06603   -21.23480 34.08082 1.000 57.57626  ? 228 GLY A N   1 
ATOM   1516 C CA  . GLY A 1 220 ? 6.36648   -22.01086 32.90307 1.000 54.63125  ? 228 GLY A CA  1 
ATOM   1517 C C   . GLY A 1 220 ? 6.97099   -21.21954 31.76824 1.000 55.72799  ? 228 GLY A C   1 
ATOM   1518 O O   . GLY A 1 220 ? 6.98453   -21.72150 30.64043 1.000 55.80067  ? 228 GLY A O   1 
ATOM   1519 N N   . ARG A 1 221 ? 7.44276   -19.99504 32.02641 1.000 52.72521  ? 229 ARG A N   1 
ATOM   1520 C CA  . ARG A 1 221 ? 8.05040   -19.13514 31.01388 1.000 48.45594  ? 229 ARG A CA  1 
ATOM   1521 C C   . ARG A 1 221 ? 8.91822   -18.09595 31.72787 1.000 45.80372  ? 229 ARG A C   1 
ATOM   1522 O O   . ARG A 1 221 ? 8.87904   -17.98404 32.96062 1.000 44.88157  ? 229 ARG A O   1 
ATOM   1523 C CB  . ARG A 1 221 ? 6.97425   -18.45855 30.14294 1.000 49.91953  ? 229 ARG A CB  1 
ATOM   1524 C CG  . ARG A 1 221 ? 5.86306   -17.77685 30.94189 1.000 50.58521  ? 229 ARG A CG  1 
ATOM   1525 C CD  . ARG A 1 221 ? 5.39437   -16.51055 30.25695 1.000 48.84578  ? 229 ARG A CD  1 
ATOM   1526 N NE  . ARG A 1 221 ? 4.24603   -15.91778 30.93459 1.000 42.77612  ? 229 ARG A NE  1 
ATOM   1527 C CZ  . ARG A 1 221 ? 4.33985   -14.93420 31.81852 1.000 50.13849  ? 229 ARG A CZ  1 
ATOM   1528 N NH1 . ARG A 1 221 ? 5.51626   -14.40105 32.13774 1.000 49.26840  ? 229 ARG A NH1 1 
ATOM   1529 N NH2 . ARG A 1 221 ? 3.22759   -14.45489 32.38037 1.000 50.87562  ? 229 ARG A NH2 1 
ATOM   1530 N N   . PRO A 1 222 ? 9.71751   -17.32081 30.99065 1.000 43.10283  ? 230 PRO A N   1 
ATOM   1531 C CA  . PRO A 1 222 ? 10.48311  -16.24913 31.63966 1.000 46.26086  ? 230 PRO A CA  1 
ATOM   1532 C C   . PRO A 1 222 ? 9.58468   -15.11464 32.11341 1.000 44.58402  ? 230 PRO A C   1 
ATOM   1533 O O   . PRO A 1 222 ? 8.45685   -14.93376 31.64574 1.000 46.13320  ? 230 PRO A O   1 
ATOM   1534 C CB  . PRO A 1 222 ? 11.44908  -15.77702 30.54359 1.000 45.27490  ? 230 PRO A CB  1 
ATOM   1535 C CG  . PRO A 1 222 ? 11.57598  -16.95203 29.63130 1.000 43.41240  ? 230 PRO A CG  1 
ATOM   1536 C CD  . PRO A 1 222 ? 10.19052  -17.54537 29.61438 1.000 46.71270  ? 230 PRO A CD  1 
ATOM   1537 N N   . LEU A 1 223 ? 10.10822  -14.35623 33.07608 1.000 42.21430  ? 231 LEU A N   1 
ATOM   1538 C CA  . LEU A 1 223 ? 9.41444   -13.18019 33.58514 1.000 47.82889  ? 231 LEU A CA  1 
ATOM   1539 C C   . LEU A 1 223 ? 9.08781   -12.20938 32.45368 1.000 42.37440  ? 231 LEU A C   1 
ATOM   1540 O O   . LEU A 1 223 ? 9.91269   -11.93855 31.57614 1.000 41.46743  ? 231 LEU A O   1 
ATOM   1541 C CB  . LEU A 1 223 ? 10.27385  -12.48727 34.64278 1.000 42.93762  ? 231 LEU A CB  1 
ATOM   1542 C CG  . LEU A 1 223 ? 9.73979   -11.20296 35.27689 1.000 41.90071  ? 231 LEU A CG  1 
ATOM   1543 C CD1 . LEU A 1 223 ? 8.44715   -11.45297 36.01631 1.000 45.75430  ? 231 LEU A CD1 1 
ATOM   1544 C CD2 . LEU A 1 223 ? 10.79113  -10.63136 36.22172 1.000 48.48208  ? 231 LEU A CD2 1 
ATOM   1545 N N   . ASP A 1 224 ? 7.86815   -11.70265 32.46802 1.000 41.94033  ? 232 ASP A N   1 
ATOM   1546 C CA  . ASP A 1 224 ? 7.44606   -10.73193 31.46721 1.000 40.93820  ? 232 ASP A CA  1 
ATOM   1547 C C   . ASP A 1 224 ? 8.10270   -9.37572  31.76326 1.000 42.35815  ? 232 ASP A C   1 
ATOM   1548 O O   . ASP A 1 224 ? 7.88867   -8.78490  32.83190 1.000 40.77759  ? 232 ASP A O   1 
ATOM   1549 C CB  . ASP A 1 224 ? 5.91667   -10.66087 31.46701 1.000 42.00673  ? 232 ASP A CB  1 
ATOM   1550 C CG  . ASP A 1 224 ? 5.34734   -9.48207  30.67904 1.000 42.03630  ? 232 ASP A CG  1 
ATOM   1551 O OD1 . ASP A 1 224 ? 6.07278   -8.77713  29.91752 1.000 41.42229  ? 232 ASP A OD1 1 
ATOM   1552 O OD2 . ASP A 1 224 ? 4.11642   -9.30081  30.79290 1.000 46.26599  ? 232 ASP A OD2 1 
ATOM   1553 N N   . LEU A 1 225 ? 8.91769   -8.89118  30.82025 1.000 38.70946  ? 233 LEU A N   1 
ATOM   1554 C CA  . LEU A 1 225 ? 9.68042   -7.66150  30.99828 1.000 40.18718  ? 233 LEU A CA  1 
ATOM   1555 C C   . LEU A 1 225 ? 9.08501   -6.48154  30.22533 1.000 41.81097  ? 233 LEU A C   1 
ATOM   1556 O O   . LEU A 1 225 ? 9.80360   -5.51765  29.91800 1.000 39.74529  ? 233 LEU A O   1 
ATOM   1557 C CB  . LEU A 1 225 ? 11.13863  -7.89641  30.60376 1.000 35.19211  ? 233 LEU A CB  1 
ATOM   1558 C CG  . LEU A 1 225 ? 11.80879  -8.90544  31.52647 1.000 36.06609  ? 233 LEU A CG  1 
ATOM   1559 C CD1 . LEU A 1 225 ? 13.24419  -9.09990  31.14140 1.000 37.33230  ? 233 LEU A CD1 1 
ATOM   1560 C CD2 . LEU A 1 225 ? 11.71618  -8.44602  32.97892 1.000 34.86758  ? 233 LEU A CD2 1 
ATOM   1561 N N   . SER A 1 226 ? 7.77290   -6.52242  29.95353 1.000 38.44951  ? 234 SER A N   1 
ATOM   1562 C CA  . SER A 1 226 ? 7.11344   -5.44918  29.21062 1.000 41.63079  ? 234 SER A CA  1 
ATOM   1563 C C   . SER A 1 226 ? 7.42020   -4.07961  29.79528 1.000 39.14984  ? 234 SER A C   1 
ATOM   1564 O O   . SER A 1 226 ? 7.78016   -3.15552  29.05909 1.000 45.50315  ? 234 SER A O   1 
ATOM   1565 C CB  . SER A 1 226 ? 5.59943   -5.67035  29.18440 1.000 41.04843  ? 234 SER A CB  1 
ATOM   1566 O OG  . SER A 1 226 ? 5.25425   -6.76681  28.35925 1.000 45.10555  ? 234 SER A OG  1 
ATOM   1567 N N   . ASN A 1 227 ? 7.32373   -3.92832  31.11738 1.000 34.75503  ? 235 ASN A N   1 
ATOM   1568 C CA  . ASN A 1 227 ? 7.54651   -2.62182  31.72931 1.000 38.82479  ? 235 ASN A CA  1 
ATOM   1569 C C   . ASN A 1 227 ? 8.87978   -2.53307  32.47732 1.000 40.72149  ? 235 ASN A C   1 
ATOM   1570 O O   . ASN A 1 227 ? 9.02020   -1.71797  33.39589 1.000 41.03291  ? 235 ASN A O   1 
ATOM   1571 C CB  . ASN A 1 227 ? 6.39655   -2.27696  32.67299 1.000 39.53400  ? 235 ASN A CB  1 
ATOM   1572 C CG  . ASN A 1 227 ? 5.06456   -2.11813  31.94476 1.000 45.21865  ? 235 ASN A CG  1 
ATOM   1573 O OD1 . ASN A 1 227 ? 4.82317   -1.12910  31.24449 1.000 42.89476  ? 235 ASN A OD1 1 
ATOM   1574 N ND2 . ASN A 1 227 ? 4.18284   -3.09325  32.13279 1.000 46.15718  ? 235 ASN A ND2 1 
ATOM   1575 N N   . SER A 1 228 ? 9.86687   -3.34697  32.10988 1.000 40.89300  ? 236 SER A N   1 
ATOM   1576 C CA  . SER A 1 228 ? 11.16394  -3.33740  32.77910 1.000 40.93598  ? 236 SER A CA  1 
ATOM   1577 C C   . SER A 1 228 ? 12.10817  -2.31191  32.13803 1.000 37.50459  ? 236 SER A C   1 
ATOM   1578 O O   . SER A 1 228 ? 12.24693  -2.26580  30.91363 1.000 39.32804  ? 236 SER A O   1 
ATOM   1579 C CB  . SER A 1 228 ? 11.77054  -4.73913  32.73287 1.000 38.42541  ? 236 SER A CB  1 
ATOM   1580 O OG  . SER A 1 228 ? 13.16646  -4.65508  32.65119 1.000 42.64125  ? 236 SER A OG  1 
ATOM   1581 N N   . ALA A 1 229 ? 12.75356  -1.49258  32.97284 1.000 32.79698  ? 237 ALA A N   1 
ATOM   1582 C CA  . ALA A 1 229 ? 13.69017  -0.48524  32.47273 1.000 39.48662  ? 237 ALA A CA  1 
ATOM   1583 C C   . ALA A 1 229 ? 14.94203  -1.11596  31.87564 1.000 40.47848  ? 237 ALA A C   1 
ATOM   1584 O O   . ALA A 1 229 ? 15.49678  -0.58360  30.90676 1.000 36.83262  ? 237 ALA A O   1 
ATOM   1585 C CB  . ALA A 1 229 ? 14.09543  0.48163   33.58881 1.000 37.83589  ? 237 ALA A CB  1 
ATOM   1586 N N   . LEU A 1 230 ? 15.38755  -2.25036  32.42472 1.000 38.78192  ? 238 LEU A N   1 
ATOM   1587 C CA  . LEU A 1 230 ? 16.63630  -2.88587  32.02412 1.000 39.32647  ? 238 LEU A CA  1 
ATOM   1588 C C   . LEU A 1 230 ? 16.46082  -3.94462  30.95043 1.000 39.42418  ? 238 LEU A C   1 
ATOM   1589 O O   . LEU A 1 230 ? 17.45667  -4.56294  30.56223 1.000 38.63759  ? 238 LEU A O   1 
ATOM   1590 C CB  . LEU A 1 230 ? 17.31949  -3.51757  33.23516 1.000 38.33442  ? 238 LEU A CB  1 
ATOM   1591 C CG  . LEU A 1 230 ? 17.70834  -2.52368  34.32768 1.000 37.97181  ? 238 LEU A CG  1 
ATOM   1592 C CD1 . LEU A 1 230 ? 18.12260  -3.24627  35.58155 1.000 36.40686  ? 238 LEU A CD1 1 
ATOM   1593 C CD2 . LEU A 1 230 ? 18.82636  -1.62807  33.84007 1.000 38.74390  ? 238 LEU A CD2 1 
ATOM   1594 N N   . ARG A 1 231 ? 15.23857  -4.13984  30.45303 1.000 37.37140  ? 239 ARG A N   1 
ATOM   1595 C CA  . ARG A 1 231 ? 14.93716  -5.20608  29.49968 1.000 39.20976  ? 239 ARG A CA  1 
ATOM   1596 C C   . ARG A 1 231 ? 15.96545  -5.25193  28.38101 1.000 41.07828  ? 239 ARG A C   1 
ATOM   1597 O O   . ARG A 1 231 ? 16.25433  -4.23482  27.74219 1.000 37.23628  ? 239 ARG A O   1 
ATOM   1598 C CB  . ARG A 1 231 ? 13.53259  -5.01186  28.90838 1.000 37.56047  ? 239 ARG A CB  1 
ATOM   1599 C CG  . ARG A 1 231 ? 13.14092  -6.07079  27.83392 1.000 39.78312  ? 239 ARG A CG  1 
ATOM   1600 C CD  . ARG A 1 231 ? 11.75124  -5.83853  27.20192 1.000 43.22500  ? 239 ARG A CD  1 
ATOM   1601 N NE  . ARG A 1 231 ? 11.45957  -4.43413  26.92031 1.000 43.59220  ? 239 ARG A NE  1 
ATOM   1602 C CZ  . ARG A 1 231 ? 11.62728  -3.83955  25.74270 1.000 48.34387  ? 239 ARG A CZ  1 
ATOM   1603 N NH1 . ARG A 1 231 ? 12.02312  -4.51291  24.67132 1.000 41.96319  ? 239 ARG A NH1 1 
ATOM   1604 N NH2 . ARG A 1 231 ? 11.38914  -2.53113  25.63586 1.000 50.17585  ? 239 ARG A NH2 1 
ATOM   1605 N N   . SER A 1 232 ? 16.54997  -6.43161  28.18111 1.000 38.83870  ? 240 SER A N   1 
ATOM   1606 C CA  . SER A 1 232 ? 17.49039  -6.61335  27.09038 1.000 38.08749  ? 240 SER A CA  1 
ATOM   1607 C C   . SER A 1 232 ? 16.75639  -6.49215  25.75732 1.000 40.47803  ? 240 SER A C   1 
ATOM   1608 O O   . SER A 1 232 ? 15.52801  -6.53821  25.68161 1.000 41.49151  ? 240 SER A O   1 
ATOM   1609 C CB  . SER A 1 232 ? 18.16570  -7.98160  27.19166 1.000 42.36867  ? 240 SER A CB  1 
ATOM   1610 O OG  . SER A 1 232 ? 17.19516  -9.01987  27.00525 1.000 44.71965  ? 240 SER A OG  1 
ATOM   1611 N N   . VAL A 1 233 ? 17.51878  -6.39348  24.68534 1.000 40.86785  ? 241 VAL A N   1 
ATOM   1612 C CA  . VAL A 1 233 ? 16.93759  -6.00164  23.41105 1.000 45.51705  ? 241 VAL A CA  1 
ATOM   1613 C C   . VAL A 1 233 ? 17.08021  -7.13311  22.40613 1.000 41.57493  ? 241 VAL A C   1 
ATOM   1614 O O   . VAL A 1 233 ? 18.02750  -7.92682  22.46323 1.000 38.85979  ? 241 VAL A O   1 
ATOM   1615 C CB  . VAL A 1 233 ? 17.55820  -4.67765  22.90555 1.000 42.92942  ? 241 VAL A CB  1 
ATOM   1616 C CG1 . VAL A 1 233 ? 18.77091  -4.30213  23.74027 1.000 41.33691  ? 241 VAL A CG1 1 
ATOM   1617 C CG2 . VAL A 1 233 ? 17.81945  -4.70541  21.40922 1.000 42.36733  ? 241 VAL A CG2 1 
ATOM   1618 N N   . SER A 1 234 ? 16.06180  -7.25226  21.53012 1.000 39.67332  ? 242 SER A N   1 
ATOM   1619 C CA  . SER A 1 234 ? 16.06214  -8.19624  20.42221 1.000 41.22023  ? 242 SER A CA  1 
ATOM   1620 C C   . SER A 1 234 ? 17.41515  -8.17589  19.71706 1.000 41.50753  ? 242 SER A C   1 
ATOM   1621 O O   . SER A 1 234 ? 17.86849  -7.10798  19.28957 1.000 41.13431  ? 242 SER A O   1 
ATOM   1622 C CB  . SER A 1 234 ? 14.94806  -7.85964  19.43641 1.000 38.80079  ? 242 SER A CB  1 
ATOM   1623 O OG  . SER A 1 234 ? 15.21297  -8.38781  18.14758 1.000 40.00117  ? 242 SER A OG  1 
ATOM   1624 N N   . PRO A 1 235 ? 18.06673  -9.33208  19.55563 1.000 39.68931  ? 243 PRO A N   1 
ATOM   1625 C CA  . PRO A 1 235 ? 19.39778  -9.34353  18.91651 1.000 42.44337  ? 243 PRO A CA  1 
ATOM   1626 C C   . PRO A 1 235 ? 19.40441  -8.71421  17.53635 1.000 41.96456  ? 243 PRO A C   1 
ATOM   1627 O O   . PRO A 1 235 ? 20.35119  -7.99697  17.19764 1.000 41.12972  ? 243 PRO A O   1 
ATOM   1628 C CB  . PRO A 1 235 ? 19.74316  -10.83759 18.86893 1.000 39.75258  ? 243 PRO A CB  1 
ATOM   1629 C CG  . PRO A 1 235 ? 18.96121  -11.43767 19.98889 1.000 41.59464  ? 243 PRO A CG  1 
ATOM   1630 C CD  . PRO A 1 235 ? 17.65815  -10.67254 20.00580 1.000 40.51468  ? 243 PRO A CD  1 
ATOM   1631 N N   . VAL A 1 236 ? 18.33364  -8.90226  16.76034 1.000 44.02331  ? 244 VAL A N   1 
ATOM   1632 C CA  . VAL A 1 236 ? 18.28357  -8.35961  15.40369 1.000 44.38040  ? 244 VAL A CA  1 
ATOM   1633 C C   . VAL A 1 236 ? 18.36974  -6.83496  15.42748 1.000 45.75669  ? 244 VAL A C   1 
ATOM   1634 O O   . VAL A 1 236 ? 19.05624  -6.22625  14.59649 1.000 50.09729  ? 244 VAL A O   1 
ATOM   1635 C CB  . VAL A 1 236 ? 17.00481  -8.84020  14.68793 1.000 50.45860  ? 244 VAL A CB  1 
ATOM   1636 C CG1 . VAL A 1 236 ? 16.97565  -8.34379  13.25963 1.000 52.26039  ? 244 VAL A CG1 1 
ATOM   1637 C CG2 . VAL A 1 236 ? 16.90444  -10.35630 14.72818 1.000 52.21824  ? 244 VAL A CG2 1 
ATOM   1638 N N   . HIS A 1 237 ? 17.70423  -6.19268  16.38834 1.000 38.40296  ? 245 HIS A N   1 
ATOM   1639 C CA  . HIS A 1 237 ? 17.80512  -4.74313  16.47053 1.000 38.95254  ? 245 HIS A CA  1 
ATOM   1640 C C   . HIS A 1 237 ? 19.13693  -4.29842  17.07111 1.000 40.34523  ? 245 HIS A C   1 
ATOM   1641 O O   . HIS A 1 237 ? 19.65034  -3.23790  16.70087 1.000 40.08897  ? 245 HIS A O   1 
ATOM   1642 C CB  . HIS A 1 237 ? 16.63930  -4.16995  17.27874 1.000 35.37954  ? 245 HIS A CB  1 
ATOM   1643 C CG  . HIS A 1 237 ? 16.67800  -2.67570  17.43487 1.000 35.31173  ? 245 HIS A CG  1 
ATOM   1644 N ND1 . HIS A 1 237 ? 16.56716  -1.80916  16.36641 1.000 36.54466  ? 245 HIS A ND1 1 
ATOM   1645 C CD2 . HIS A 1 237 ? 16.78744  -1.89599  18.53835 1.000 34.43014  ? 245 HIS A CD2 1 
ATOM   1646 C CE1 . HIS A 1 237 ? 16.64651  -0.56237  16.80079 1.000 33.65979  ? 245 HIS A CE1 1 
ATOM   1647 N NE2 . HIS A 1 237 ? 16.76894  -0.58524  18.11666 1.000 31.22488  ? 245 HIS A NE2 1 
ATOM   1648 N N   . LEU A 1 238 ? 19.68102  -5.05021  18.02846 1.000 36.65933  ? 246 LEU A N   1 
ATOM   1649 C CA  . LEU A 1 238 ? 20.98363  -4.69224  18.58507 1.000 42.51502  ? 246 LEU A CA  1 
ATOM   1650 C C   . LEU A 1 238 ? 22.05596  -4.71830  17.50157 1.000 41.91046  ? 246 LEU A C   1 
ATOM   1651 O O   . LEU A 1 238 ? 22.94593  -3.85193  17.46256 1.000 38.15608  ? 246 LEU A O   1 
ATOM   1652 C CB  . LEU A 1 238 ? 21.35037  -5.64232  19.72666 1.000 43.51869  ? 246 LEU A CB  1 
ATOM   1653 C CG  . LEU A 1 238 ? 21.12132  -5.25380  21.18859 1.000 44.05374  ? 246 LEU A CG  1 
ATOM   1654 C CD1 . LEU A 1 238 ? 21.94992  -6.17938  22.10140 1.000 45.14119  ? 246 LEU A CD1 1 
ATOM   1655 C CD2 . LEU A 1 238 ? 21.38519  -3.75969  21.48397 1.000 33.62176  ? 246 LEU A CD2 1 
ATOM   1656 N N   . GLU A 1 239 ? 21.96577  -5.70346  16.60159 1.000 40.57495  ? 247 GLU A N   1 
ATOM   1657 C CA  . GLU A 1 239 ? 22.89290  -5.81475  15.47896 1.000 43.81164  ? 247 GLU A CA  1 
ATOM   1658 C C   . GLU A 1 239 ? 22.71621  -4.65149  14.50295 1.000 46.76041  ? 247 GLU A C   1 
ATOM   1659 O O   . GLU A 1 239 ? 23.69768  -4.12956  13.96284 1.000 46.19166  ? 247 GLU A O   1 
ATOM   1660 C CB  . GLU A 1 239 ? 22.66282  -7.15922  14.80450 1.000 45.07975  ? 247 GLU A CB  1 
ATOM   1661 C CG  . GLU A 1 239 ? 23.79404  -7.76321  14.04268 1.000 50.17935  ? 247 GLU A CG  1 
ATOM   1662 C CD  . GLU A 1 239 ? 23.36402  -9.07575  13.41426 1.000 58.88133  ? 247 GLU A CD  1 
ATOM   1663 O OE1 . GLU A 1 239 ? 22.21697  -9.12520  12.91831 1.000 66.14013  ? 247 GLU A OE1 1 
ATOM   1664 O OE2 . GLU A 1 239 ? 24.14180  -10.05928 13.42632 1.000 64.53668  ? 247 GLU A OE2 1 
ATOM   1665 N N   . TYR A 1 240 ? 21.47725  -4.19097  14.30019 1.000 41.80320  ? 248 TYR A N   1 
ATOM   1666 C CA  . TYR A 1 240 ? 21.26960  -3.05098  13.41425 1.000 43.64715  ? 248 TYR A CA  1 
ATOM   1667 C C   . TYR A 1 240 ? 21.91757  -1.78502  13.97600 1.000 42.26959  ? 248 TYR A C   1 
ATOM   1668 O O   . TYR A 1 240 ? 22.51725  -0.99647  13.22627 1.000 42.72308  ? 248 TYR A O   1 
ATOM   1669 C CB  . TYR A 1 240 ? 19.76190  -2.86127  13.16443 1.000 44.57259  ? 248 TYR A CB  1 
ATOM   1670 C CG  . TYR A 1 240 ? 19.33526  -1.43762  12.82515 1.000 45.81871  ? 248 TYR A CG  1 
ATOM   1671 C CD1 . TYR A 1 240 ? 19.33299  -0.97602  11.51284 1.000 45.65746  ? 248 TYR A CD1 1 
ATOM   1672 C CD2 . TYR A 1 240 ? 18.94170  -0.55712  13.83135 1.000 43.11189  ? 248 TYR A CD2 1 
ATOM   1673 C CE1 . TYR A 1 240 ? 18.94645  0.32704   11.21141 1.000 48.26209  ? 248 TYR A CE1 1 
ATOM   1674 C CE2 . TYR A 1 240 ? 18.56747  0.74856   13.54626 1.000 46.12610  ? 248 TYR A CE2 1 
ATOM   1675 C CZ  . TYR A 1 240 ? 18.56582  1.18635   12.23351 1.000 48.97183  ? 248 TYR A CZ  1 
ATOM   1676 O OH  . TYR A 1 240 ? 18.19061  2.48633   11.96425 1.000 52.55381  ? 248 TYR A OH  1 
ATOM   1677 N N   . LEU A 1 241 ? 21.82805  -1.58003  15.29303 1.000 36.21588  ? 249 LEU A N   1 
ATOM   1678 C CA  . LEU A 1 241 ? 22.51149  -0.44727  15.90614 1.000 36.35806  ? 249 LEU A CA  1 
ATOM   1679 C C   . LEU A 1 241 ? 24.03195  -0.57523  15.77230 1.000 44.40923  ? 249 LEU A C   1 
ATOM   1680 O O   . LEU A 1 241 ? 24.72596  0.40640   15.45294 1.000 42.95069  ? 249 LEU A O   1 
ATOM   1681 C CB  . LEU A 1 241 ? 22.10182  -0.33742  17.37605 1.000 36.41649  ? 249 LEU A CB  1 
ATOM   1682 C CG  . LEU A 1 241 ? 20.62141  -0.02137  17.66746 1.000 38.83457  ? 249 LEU A CG  1 
ATOM   1683 C CD1 . LEU A 1 241 ? 20.37926  -0.03272  19.16917 1.000 36.38325  ? 249 LEU A CD1 1 
ATOM   1684 C CD2 . LEU A 1 241 ? 20.15476  1.30844   17.03868 1.000 36.71534  ? 249 LEU A CD2 1 
ATOM   1685 N N   . ARG A 1 242 ? 24.57543  -1.77392  16.02949 1.000 37.28926  ? 250 ARG A N   1 
ATOM   1686 C CA  . ARG A 1 242 ? 26.02310  -1.92816  15.96369 1.000 42.85166  ? 250 ARG A CA  1 
ATOM   1687 C C   . ARG A 1 242 ? 26.52957  -1.63843  14.55614 1.000 43.88460  ? 250 ARG A C   1 
ATOM   1688 O O   . ARG A 1 242 ? 27.53672  -0.93806  14.38349 1.000 47.07744  ? 250 ARG A O   1 
ATOM   1689 C CB  . ARG A 1 242 ? 26.44173  -3.32774  16.44714 1.000 37.40601  ? 250 ARG A CB  1 
ATOM   1690 C CG  . ARG A 1 242 ? 26.44296  -3.43696  17.97913 1.000 41.01559  ? 250 ARG A CG  1 
ATOM   1691 C CD  . ARG A 1 242 ? 27.19744  -4.65152  18.48682 1.000 39.41434  ? 250 ARG A CD  1 
ATOM   1692 N NE  . ARG A 1 242 ? 26.57598  -5.88940  18.02971 1.000 42.10898  ? 250 ARG A NE  1 
ATOM   1693 C CZ  . ARG A 1 242 ? 25.60157  -6.53894  18.65715 1.000 44.03086  ? 250 ARG A CZ  1 
ATOM   1694 N NH1 . ARG A 1 242 ? 25.12236  -6.12117  19.81955 1.000 40.46257  ? 250 ARG A NH1 1 
ATOM   1695 N NH2 . ARG A 1 242 ? 25.10344  -7.64207  18.10712 1.000 42.17827  ? 250 ARG A NH2 1 
ATOM   1696 N N   . ASN A 1 243 ? 25.81867  -2.11446  13.53216 1.000 43.58469  ? 251 ASN A N   1 
ATOM   1697 C CA  . ASN A 1 243 ? 26.28726  -1.85839  12.17741 1.000 45.38843  ? 251 ASN A CA  1 
ATOM   1698 C C   . ASN A 1 243 ? 26.34615  -0.36665  11.89133 1.000 49.04314  ? 251 ASN A C   1 
ATOM   1699 O O   . ASN A 1 243 ? 27.15190  0.06847   11.05357 1.000 49.63162  ? 251 ASN A O   1 
ATOM   1700 C CB  . ASN A 1 243 ? 25.40067  -2.57000  11.15529 1.000 47.64745  ? 251 ASN A CB  1 
ATOM   1701 C CG  . ASN A 1 243 ? 25.47638  -4.09723  11.26429 1.000 51.72349  ? 251 ASN A CG  1 
ATOM   1702 O OD1 . ASN A 1 243 ? 24.61573  -4.80607  10.73742 1.000 59.33231  ? 251 ASN A OD1 1 
ATOM   1703 N ND2 . ASN A 1 243 ? 26.46082  -4.60039  11.99194 1.000 51.67017  ? 251 ASN A ND2 1 
ATOM   1704 N N   . MET A 1 244 ? 25.53241  0.43662   12.59333 1.000 43.15787  ? 252 MET A N   1 
ATOM   1705 C CA  . MET A 1 244 ? 25.56816  1.88599   12.43539 1.000 45.24388  ? 252 MET A CA  1 
ATOM   1706 C C   . MET A 1 244 ? 26.61206  2.54976   13.32523 1.000 47.18536  ? 252 MET A C   1 
ATOM   1707 O O   . MET A 1 244 ? 26.73576  3.77790   13.30779 1.000 51.86526  ? 252 MET A O   1 
ATOM   1708 C CB  . MET A 1 244 ? 24.18961  2.48676   12.73730 1.000 49.10722  ? 252 MET A CB  1 
ATOM   1709 C CG  . MET A 1 244 ? 23.21911  2.38201   11.56946 1.000 52.88212  ? 252 MET A CG  1 
ATOM   1710 S SD  . MET A 1 244 ? 21.71434  3.37189   11.74746 1.000 61.79465  ? 252 MET A SD  1 
ATOM   1711 C CE  . MET A 1 244 ? 21.17132  2.94131   13.41198 1.000 48.38722  ? 252 MET A CE  1 
ATOM   1712 N N   . GLY A 1 245 ? 27.37117  1.77872   14.09674 1.000 45.01918  ? 253 GLY A N   1 
ATOM   1713 C CA  . GLY A 1 245 ? 28.29199  2.38046   15.02988 1.000 44.14266  ? 253 GLY A CA  1 
ATOM   1714 C C   . GLY A 1 245 ? 27.62234  3.04540   16.20554 1.000 45.24862  ? 253 GLY A C   1 
ATOM   1715 O O   . GLY A 1 245 ? 28.24682  3.85925   16.89010 1.000 45.61434  ? 253 GLY A O   1 
ATOM   1716 N N   . VAL A 1 246 ? 26.37448  2.69527   16.48369 1.000 44.21745  ? 254 VAL A N   1 
ATOM   1717 C CA  . VAL A 1 246 ? 25.62670  3.32436   17.55952 1.000 41.51804  ? 254 VAL A CA  1 
ATOM   1718 C C   . VAL A 1 246 ? 25.98769  2.65681   18.87558 1.000 37.00741  ? 254 VAL A C   1 
ATOM   1719 O O   . VAL A 1 246 ? 25.95426  1.43069   18.99131 1.000 39.64461  ? 254 VAL A O   1 
ATOM   1720 C CB  . VAL A 1 246 ? 24.11985  3.24577   17.27257 1.000 40.30457  ? 254 VAL A CB  1 
ATOM   1721 C CG1 . VAL A 1 246 ? 23.30836  3.74448   18.47668 1.000 39.79070  ? 254 VAL A CG1 1 
ATOM   1722 C CG2 . VAL A 1 246 ? 23.80925  4.02783   16.01553 1.000 39.85750  ? 254 VAL A CG2 1 
ATOM   1723 N N   . GLY A 1 247 ? 26.34958  3.46131   19.86726 1.000 40.96825  ? 255 GLY A N   1 
ATOM   1724 C CA  . GLY A 1 247 ? 26.54693  2.93967   21.20087 1.000 39.54851  ? 255 GLY A CA  1 
ATOM   1725 C C   . GLY A 1 247 ? 25.28035  3.03326   22.01883 1.000 39.34432  ? 255 GLY A C   1 
ATOM   1726 O O   . GLY A 1 247 ? 24.63811  2.01983   22.30001 1.000 41.81886  ? 255 GLY A O   1 
ATOM   1727 N N   . ALA A 1 248 ? 24.88922  4.24196   22.39180 1.000 39.68792  ? 256 ALA A N   1 
ATOM   1728 C CA  . ALA A 1 248 ? 23.67234  4.41843   23.16011 1.000 38.64417  ? 256 ALA A CA  1 
ATOM   1729 C C   . ALA A 1 248 ? 22.50537  4.72266   22.23307 1.000 40.57393  ? 256 ALA A C   1 
ATOM   1730 O O   . ALA A 1 248 ? 22.67499  5.29011   21.14780 1.000 40.69366  ? 256 ALA A O   1 
ATOM   1731 C CB  . ALA A 1 248 ? 23.84424  5.53319   24.18434 1.000 37.69833  ? 256 ALA A CB  1 
ATOM   1732 N N   . SER A 1 249 ? 21.31672  4.29705   22.65384 1.000 38.12867  ? 257 SER A N   1 
ATOM   1733 C CA  . SER A 1 249 ? 20.07953  4.58151   21.93549 1.000 38.93283  ? 257 SER A CA  1 
ATOM   1734 C C   . SER A 1 249 ? 18.98739  4.86944   22.96150 1.000 36.76204  ? 257 SER A C   1 
ATOM   1735 O O   . SER A 1 249 ? 18.78484  4.09198   23.89771 1.000 37.46153  ? 257 SER A O   1 
ATOM   1736 C CB  . SER A 1 249 ? 19.71899  3.40577   21.02030 1.000 38.50728  ? 257 SER A CB  1 
ATOM   1737 O OG  . SER A 1 249 ? 18.43215  3.51196   20.46687 1.000 46.43721  ? 257 SER A OG  1 
ATOM   1738 N N   . PHE A 1 250 ? 18.30842  5.99823   22.80520 1.000 40.86695  ? 258 PHE A N   1 
ATOM   1739 C CA  . PHE A 1 250 ? 17.31013  6.47330   23.76436 1.000 40.81245  ? 258 PHE A CA  1 
ATOM   1740 C C   . PHE A 1 250 ? 16.08509  6.91922   22.98976 1.000 38.76179  ? 258 PHE A C   1 
ATOM   1741 O O   . PHE A 1 250 ? 16.19015  7.79189   22.12379 1.000 39.75028  ? 258 PHE A O   1 
ATOM   1742 C CB  . PHE A 1 250 ? 17.87231  7.61735   24.61541 1.000 36.49008  ? 258 PHE A CB  1 
ATOM   1743 C CG  . PHE A 1 250 ? 16.87072  8.23269   25.59044 1.000 39.98502  ? 258 PHE A CG  1 
ATOM   1744 C CD1 . PHE A 1 250 ? 16.41723  7.52159   26.70375 1.000 33.82859  ? 258 PHE A CD1 1 
ATOM   1745 C CD2 . PHE A 1 250 ? 16.44288  9.55649   25.42110 1.000 36.27523  ? 258 PHE A CD2 1 
ATOM   1746 C CE1 . PHE A 1 250 ? 15.54435  8.09888   27.61028 1.000 36.18957  ? 258 PHE A CE1 1 
ATOM   1747 C CE2 . PHE A 1 250 ? 15.56147  10.14703  26.32925 1.000 38.04641  ? 258 PHE A CE2 1 
ATOM   1748 C CZ  . PHE A 1 250 ? 15.09906  9.41450   27.41833 1.000 36.96502  ? 258 PHE A CZ  1 
ATOM   1749 N N   . SER A 1 251 ? 14.94045  6.29568   23.27234 1.000 37.57863  ? 259 SER A N   1 
ATOM   1750 C CA  . SER A 1 251 ? 13.72899  6.43641   22.47112 1.000 36.82736  ? 259 SER A CA  1 
ATOM   1751 C C   . SER A 1 251 ? 12.58375  6.96226   23.32315 1.000 36.82722  ? 259 SER A C   1 
ATOM   1752 O O   . SER A 1 251 ? 12.48306  6.62900   24.50783 1.000 35.36799  ? 259 SER A O   1 
ATOM   1753 C CB  . SER A 1 251 ? 13.32660  5.10341   21.83504 1.000 42.28298  ? 259 SER A CB  1 
ATOM   1754 O OG  . SER A 1 251 ? 14.45573  4.52985   21.18363 1.000 48.59223  ? 259 SER A OG  1 
ATOM   1755 N N   . LEU A 1 252 ? 11.74532  7.80811   22.71221 1.000 36.32976  ? 260 LEU A N   1 
ATOM   1756 C CA  . LEU A 1 252 ? 10.56821  8.40282   23.33870 1.000 35.64555  ? 260 LEU A CA  1 
ATOM   1757 C C   . LEU A 1 252 ? 9.35001   8.07936   22.49201 1.000 35.62027  ? 260 LEU A C   1 
ATOM   1758 O O   . LEU A 1 252 ? 9.35766   8.30960   21.27673 1.000 36.03449  ? 260 LEU A O   1 
ATOM   1759 C CB  . LEU A 1 252 ? 10.68719  9.93647   23.47006 1.000 32.73641  ? 260 LEU A CB  1 
ATOM   1760 C CG  . LEU A 1 252 ? 11.79710  10.56406  24.33096 1.000 37.84075  ? 260 LEU A CG  1 
ATOM   1761 C CD1 . LEU A 1 252 ? 13.15598  10.34626  23.72203 1.000 38.37295  ? 260 LEU A CD1 1 
ATOM   1762 C CD2 . LEU A 1 252 ? 11.59280  12.07571  24.49446 1.000 41.22920  ? 260 LEU A CD2 1 
ATOM   1763 N N   . SER A 1 253 ? 8.29739   7.58341   23.12444 1.000 32.75145  ? 261 SER A N   1 
ATOM   1764 C CA  . SER A 1 253 ? 7.07313   7.27405   22.40234 1.000 37.60502  ? 261 SER A CA  1 
ATOM   1765 C C   . SER A 1 253 ? 6.19610   8.51586   22.31484 1.000 32.49013  ? 261 SER A C   1 
ATOM   1766 O O   . SER A 1 253 ? 5.97925   9.19768   23.31495 1.000 34.22641  ? 261 SER A O   1 
ATOM   1767 C CB  . SER A 1 253 ? 6.31472   6.13184   23.08019 1.000 30.78756  ? 261 SER A CB  1 
ATOM   1768 O OG  . SER A 1 253 ? 7.18461   5.02444   23.20877 1.000 37.68834  ? 261 SER A OG  1 
ATOM   1769 N N   . LEU A 1 254 ? 5.71392   8.81473   21.11598 1.000 32.21492  ? 262 LEU A N   1 
ATOM   1770 C CA  . LEU A 1 254 ? 4.75026   9.89185   20.90267 1.000 34.37250  ? 262 LEU A CA  1 
ATOM   1771 C C   . LEU A 1 254 ? 3.37518   9.25917   20.80673 1.000 33.37102  ? 262 LEU A C   1 
ATOM   1772 O O   . LEU A 1 254 ? 3.10401   8.50031   19.87272 1.000 35.30932  ? 262 LEU A O   1 
ATOM   1773 C CB  . LEU A 1 254 ? 5.05402   10.68752  19.64014 1.000 31.37763  ? 262 LEU A CB  1 
ATOM   1774 C CG  . LEU A 1 254 ? 6.37080   11.46482  19.67729 1.000 33.20231  ? 262 LEU A CG  1 
ATOM   1775 C CD1 . LEU A 1 254 ? 6.54262   12.21691  18.38101 1.000 29.43360  ? 262 LEU A CD1 1 
ATOM   1776 C CD2 . LEU A 1 254 ? 6.36586   12.40054  20.85185 1.000 28.87550  ? 262 LEU A CD2 1 
ATOM   1777 N N   . LEU A 1 255 ? 2.52386   9.54145   21.78680 1.000 34.75877  ? 263 LEU A N   1 
ATOM   1778 C CA  . LEU A 1 255 ? 1.15139   9.07658   21.76734 1.000 35.14804  ? 263 LEU A CA  1 
ATOM   1779 C C   . LEU A 1 255 ? 0.20853   10.22201  21.41364 1.000 41.77875  ? 263 LEU A C   1 
ATOM   1780 O O   . LEU A 1 255 ? 0.46742   11.38430  21.73347 1.000 35.76425  ? 263 LEU A O   1 
ATOM   1781 C CB  . LEU A 1 255 ? 0.74605   8.48701   23.11545 1.000 37.90027  ? 263 LEU A CB  1 
ATOM   1782 C CG  . LEU A 1 255 ? 1.51142   7.31698   23.71173 1.000 41.41732  ? 263 LEU A CG  1 
ATOM   1783 C CD1 . LEU A 1 255 ? 0.70235   6.76906   24.86803 1.000 43.58213  ? 263 LEU A CD1 1 
ATOM   1784 C CD2 . LEU A 1 255 ? 1.74673   6.25447   22.68330 1.000 37.26157  ? 263 LEU A CD2 1 
ATOM   1785 N N   . LYS A 1 256 ? -0.89295  9.88002   20.74892 1.000 38.60678  ? 264 LYS A N   1 
ATOM   1786 C CA  . LYS A 1 256 ? -1.99687  10.80834  20.55553 1.000 44.30856  ? 264 LYS A CA  1 
ATOM   1787 C C   . LYS A 1 256 ? -3.26255  10.12488  21.03852 1.000 44.79510  ? 264 LYS A C   1 
ATOM   1788 O O   . LYS A 1 256 ? -3.63985  9.07020   20.51110 1.000 39.16563  ? 264 LYS A O   1 
ATOM   1789 C CB  . LYS A 1 256 ? -2.13721  11.24039  19.09670 1.000 45.23482  ? 264 LYS A CB  1 
ATOM   1790 C CG  . LYS A 1 256 ? -3.34153  12.15602  18.86322 1.000 49.98710  ? 264 LYS A CG  1 
ATOM   1791 C CD  . LYS A 1 256 ? -3.52014  12.40671  17.38267 1.000 51.66792  ? 264 LYS A CD  1 
ATOM   1792 C CE  . LYS A 1 256 ? -4.71428  13.28859  17.09830 1.000 65.09141  ? 264 LYS A CE  1 
ATOM   1793 N NZ  . LYS A 1 256 ? -4.83031  13.53788  15.63952 1.000 59.97406  ? 264 LYS A NZ  1 
ATOM   1794 N N   . GLU A 1 257 ? -3.88890  10.70578  22.05932 1.000 43.50747  ? 265 GLU A N   1 
ATOM   1795 C CA  . GLU A 1 257 ? -5.08911  10.13380  22.65380 1.000 50.23163  ? 265 GLU A CA  1 
ATOM   1796 C C   . GLU A 1 257 ? -4.86173  8.66436   23.00803 1.000 46.53974  ? 265 GLU A C   1 
ATOM   1797 O O   . GLU A 1 257 ? -5.65455  7.78260   22.67590 1.000 45.84913  ? 265 GLU A O   1 
ATOM   1798 C CB  . GLU A 1 257 ? -6.30153  10.31384  21.72895 1.000 48.27707  ? 265 GLU A CB  1 
ATOM   1799 C CG  . GLU A 1 257 ? -6.91610  11.71401  21.79453 1.000 62.33826  ? 265 GLU A CG  1 
ATOM   1800 C CD  . GLU A 1 257 ? -7.58976  12.13998  20.49702 1.000 70.04262  ? 265 GLU A CD  1 
ATOM   1801 O OE1 . GLU A 1 257 ? -7.52495  13.35038  20.14972 1.000 69.92957  ? 265 GLU A OE1 1 
ATOM   1802 O OE2 . GLU A 1 257 ? -8.19591  11.26482  19.83648 1.000 65.95176  ? 265 GLU A OE2 1 
ATOM   1803 N N   . GLY A 1 258 ? -3.73833  8.40384   23.67782 1.000 46.36813  ? 266 GLY A N   1 
ATOM   1804 C CA  . GLY A 1 258 ? -3.44890  7.07680   24.17033 1.000 41.80864  ? 266 GLY A CA  1 
ATOM   1805 C C   . GLY A 1 258 ? -3.07718  6.05958   23.11793 1.000 43.38804  ? 266 GLY A C   1 
ATOM   1806 O O   . GLY A 1 258 ? -2.90113  4.88470   23.45983 1.000 43.28474  ? 266 GLY A O   1 
ATOM   1807 N N   . VAL A 1 259 ? -2.93947  6.46041   21.85754 1.000 39.04644  ? 267 VAL A N   1 
ATOM   1808 C CA  . VAL A 1 259 ? -2.58867  5.55522   20.77534 1.000 38.95574  ? 267 VAL A CA  1 
ATOM   1809 C C   . VAL A 1 259 ? -1.21963  5.93511   20.21562 1.000 41.31192  ? 267 VAL A C   1 
ATOM   1810 O O   . VAL A 1 259 ? -0.88142  7.12185   20.10704 1.000 39.94331  ? 267 VAL A O   1 
ATOM   1811 C CB  . VAL A 1 259 ? -3.67932  5.56386   19.68887 1.000 45.50220  ? 267 VAL A CB  1 
ATOM   1812 C CG1 . VAL A 1 259 ? -3.16035  5.03556   18.36802 1.000 43.93649  ? 267 VAL A CG1 1 
ATOM   1813 C CG2 . VAL A 1 259 ? -4.88432  4.72941   20.17971 1.000 45.97915  ? 267 VAL A CG2 1 
ATOM   1814 N N   . LEU A 1 260 ? -0.42287  4.92117   19.88018 1.000 35.92523  ? 268 LEU A N   1 
ATOM   1815 C CA  . LEU A 1 260 ? 0.92214   5.18000   19.39398 1.000 36.34168  ? 268 LEU A CA  1 
ATOM   1816 C C   . LEU A 1 260 ? 0.87318   5.96807   18.09233 1.000 36.30745  ? 268 LEU A C   1 
ATOM   1817 O O   . LEU A 1 260 ? 0.22291   5.56674   17.12341 1.000 39.50157  ? 268 LEU A O   1 
ATOM   1818 C CB  . LEU A 1 260 ? 1.68392   3.87251   19.20158 1.000 36.92298  ? 268 LEU A CB  1 
ATOM   1819 C CG  . LEU A 1 260 ? 3.13433   4.06700   18.73383 1.000 35.19211  ? 268 LEU A CG  1 
ATOM   1820 C CD1 . LEU A 1 260 ? 3.96685   4.78056   19.80448 1.000 31.08131  ? 268 LEU A CD1 1 
ATOM   1821 C CD2 . LEU A 1 260 ? 3.73575   2.70336   18.34640 1.000 33.45250  ? 268 LEU A CD2 1 
ATOM   1822 N N   . TRP A 1 261 ? 1.56317   7.10379   18.08150 1.000 34.70184  ? 269 TRP A N   1 
ATOM   1823 C CA  . TRP A 1 261 ? 1.58784   8.02068   16.94908 1.000 37.91085  ? 269 TRP A CA  1 
ATOM   1824 C C   . TRP A 1 261 ? 2.96267   8.13330   16.30724 1.000 36.30451  ? 269 TRP A C   1 
ATOM   1825 O O   . TRP A 1 261 ? 3.07377   8.23506   15.07896 1.000 35.67181  ? 269 TRP A O   1 
ATOM   1826 C CB  . TRP A 1 261 ? 1.10017   9.40743   17.42313 1.000 38.70521  ? 269 TRP A CB  1 
ATOM   1827 C CG  . TRP A 1 261 ? 1.00701   10.50841  16.38754 1.000 41.27901  ? 269 TRP A CG  1 
ATOM   1828 C CD1 . TRP A 1 261 ? -0.11096  10.88196  15.68463 1.000 41.47473  ? 269 TRP A CD1 1 
ATOM   1829 C CD2 . TRP A 1 261 ? 2.05821   11.40333  15.97141 1.000 37.15338  ? 269 TRP A CD2 1 
ATOM   1830 N NE1 . TRP A 1 261 ? 0.18799   11.93640  14.85136 1.000 41.88097  ? 269 TRP A NE1 1 
ATOM   1831 C CE2 . TRP A 1 261 ? 1.50410   12.28322  15.01312 1.000 40.03343  ? 269 TRP A CE2 1 
ATOM   1832 C CE3 . TRP A 1 261 ? 3.39788   11.56343  16.33530 1.000 40.07424  ? 269 TRP A CE3 1 
ATOM   1833 C CZ2 . TRP A 1 261 ? 2.25239   13.29317  14.39304 1.000 43.47497  ? 269 TRP A CZ2 1 
ATOM   1834 C CZ3 . TRP A 1 261 ? 4.15285   12.57941  15.70824 1.000 40.24753  ? 269 TRP A CZ3 1 
ATOM   1835 C CH2 . TRP A 1 261 ? 3.57433   13.41929  14.74727 1.000 37.41988  ? 269 TRP A CH2 1 
ATOM   1836 N N   . GLY A 1 262 ? 4.02432   8.06768   17.09539 1.000 31.46483  ? 270 GLY A N   1 
ATOM   1837 C CA  . GLY A 1 262 ? 5.32435   8.30270   16.50910 1.000 34.13632  ? 270 GLY A CA  1 
ATOM   1838 C C   . GLY A 1 262 ? 6.39356   7.98318   17.51875 1.000 33.63637  ? 270 GLY A C   1 
ATOM   1839 O O   . GLY A 1 262 ? 6.11704   7.57970   18.64889 1.000 36.30591  ? 270 GLY A O   1 
ATOM   1840 N N   . LEU A 1 263 ? 7.63022   8.17332   17.09721 1.000 39.30801  ? 271 LEU A N   1 
ATOM   1841 C CA  . LEU A 1 263 ? 8.75786   7.75352   17.91113 1.000 35.14162  ? 271 LEU A CA  1 
ATOM   1842 C C   . LEU A 1 263 ? 9.88111   8.75628   17.70366 1.000 33.91772  ? 271 LEU A C   1 
ATOM   1843 O O   . LEU A 1 263 ? 10.15457  9.15354   16.56864 1.000 34.71814  ? 271 LEU A O   1 
ATOM   1844 C CB  . LEU A 1 263 ? 9.18934   6.34327   17.50940 1.000 38.13553  ? 271 LEU A CB  1 
ATOM   1845 C CG  . LEU A 1 263 ? 9.94840   5.53389   18.53884 1.000 41.66987  ? 271 LEU A CG  1 
ATOM   1846 C CD1 . LEU A 1 263 ? 9.01643   5.26997   19.71390 1.000 39.28161  ? 271 LEU A CD1 1 
ATOM   1847 C CD2 . LEU A 1 263 ? 10.37972  4.23690   17.89664 1.000 48.00328  ? 271 LEU A CD2 1 
ATOM   1848 N N   . ILE A 1 264 ? 10.49136  9.19558   18.79288 1.000 34.28952  ? 272 ILE A N   1 
ATOM   1849 C CA  . ILE A 1 264 ? 11.70910  9.99410   18.74575 1.000 39.14709  ? 272 ILE A CA  1 
ATOM   1850 C C   . ILE A 1 264 ? 12.88629  9.10481   19.11815 1.000 36.59135  ? 272 ILE A C   1 
ATOM   1851 O O   . ILE A 1 264 ? 12.94780  8.59090   20.23901 1.000 40.49153  ? 272 ILE A O   1 
ATOM   1852 C CB  . ILE A 1 264 ? 11.61834  11.20545  19.68309 1.000 39.72734  ? 272 ILE A CB  1 
ATOM   1853 C CG1 . ILE A 1 264 ? 10.41602  12.08111  19.29589 1.000 36.07295  ? 272 ILE A CG1 1 
ATOM   1854 C CG2 . ILE A 1 264 ? 12.93173  11.97828  19.62822 1.000 34.87798  ? 272 ILE A CG2 1 
ATOM   1855 C CD1 . ILE A 1 264 ? 10.18203  13.25176  20.22944 1.000 37.74847  ? 272 ILE A CD1 1 
ATOM   1856 N N   . ALA A 1 265 ? 13.82482  8.91764   18.19436 1.000 40.20875  ? 273 ALA A N   1 
ATOM   1857 C CA  . ALA A 1 265 ? 14.95745  8.01249   18.38910 1.000 37.09735  ? 273 ALA A CA  1 
ATOM   1858 C C   . ALA A 1 265 ? 16.26261  8.79643   18.48552 1.000 40.86820  ? 273 ALA A C   1 
ATOM   1859 O O   . ALA A 1 265 ? 16.65875  9.46877   17.53071 1.000 42.60274  ? 273 ALA A O   1 
ATOM   1860 C CB  . ALA A 1 265 ? 15.04382  7.00472   17.24455 1.000 37.90693  ? 273 ALA A CB  1 
ATOM   1861 N N   . CYS A 1 266 ? 16.94386  8.67679   19.61999 1.000 34.24851  ? 274 CYS A N   1 
ATOM   1862 C CA  . CYS A 1 266 ? 18.20768  9.33724   19.84400 1.000 35.54625  ? 274 CYS A CA  1 
ATOM   1863 C C   . CYS A 1 266 ? 19.31611  8.29074   19.73808 1.000 40.02584  ? 274 CYS A C   1 
ATOM   1864 O O   . CYS A 1 266 ? 19.23167  7.21785   20.34271 1.000 38.97065  ? 274 CYS A O   1 
ATOM   1865 C CB  . CYS A 1 266 ? 18.22546  10.04217  21.20733 1.000 31.50843  ? 274 CYS A CB  1 
ATOM   1866 S SG  . CYS A 1 266 ? 16.67655  10.98712  21.56912 1.000 38.24613  ? 274 CYS A SG  1 
ATOM   1867 N N   . HIS A 1 267 ? 20.33033  8.59361   18.93829 1.000 39.76668  ? 275 HIS A N   1 
ATOM   1868 C CA  . HIS A 1 267 ? 21.47154  7.71036   18.73940 1.000 38.95141  ? 275 HIS A CA  1 
ATOM   1869 C C   . HIS A 1 267 ? 22.73459  8.48905   19.05033 1.000 37.14436  ? 275 HIS A C   1 
ATOM   1870 O O   . HIS A 1 267 ? 22.88107  9.63473   18.61555 1.000 37.34179  ? 275 HIS A O   1 
ATOM   1871 C CB  . HIS A 1 267 ? 21.50930  7.15679   17.30617 1.000 39.59535  ? 275 HIS A CB  1 
ATOM   1872 C CG  . HIS A 1 267 ? 20.39395  6.20343   16.99892 1.000 40.30204  ? 275 HIS A CG  1 
ATOM   1873 N ND1 . HIS A 1 267 ? 20.05426  5.84082   15.71210 1.000 42.53692  ? 275 HIS A ND1 1 
ATOM   1874 C CD2 . HIS A 1 267 ? 19.53107  5.54788   17.81286 1.000 38.55604  ? 275 HIS A CD2 1 
ATOM   1875 C CE1 . HIS A 1 267 ? 19.02967  5.00730   15.74522 1.000 40.97702  ? 275 HIS A CE1 1 
ATOM   1876 N NE2 . HIS A 1 267 ? 18.68850  4.81735   17.00647 1.000 40.04307  ? 275 HIS A NE2 1 
ATOM   1877 N N   . HIS A 1 268 ? 23.63140  7.86602   19.81436 1.000 38.68268  ? 276 HIS A N   1 
ATOM   1878 C CA  . HIS A 1 268 ? 24.93396  8.41055   20.16349 1.000 39.63493  ? 276 HIS A CA  1 
ATOM   1879 C C   . HIS A 1 268 ? 25.98634  7.34566   19.87723 1.000 42.68206  ? 276 HIS A C   1 
ATOM   1880 O O   . HIS A 1 268 ? 25.76380  6.15846   20.14888 1.000 38.57632  ? 276 HIS A O   1 
ATOM   1881 C CB  . HIS A 1 268 ? 24.99412  8.81537   21.63546 1.000 38.89278  ? 276 HIS A CB  1 
ATOM   1882 C CG  . HIS A 1 268 ? 26.10112  9.77751   21.95833 1.000 43.05010  ? 276 HIS A CG  1 
ATOM   1883 N ND1 . HIS A 1 268 ? 26.13947  11.06060  21.45649 1.000 41.57122  ? 276 HIS A ND1 1 
ATOM   1884 C CD2 . HIS A 1 268 ? 27.20274  9.64650   22.73680 1.000 43.14324  ? 276 HIS A CD2 1 
ATOM   1885 C CE1 . HIS A 1 268 ? 27.20807  11.68315  21.92050 1.000 41.43986  ? 276 HIS A CE1 1 
ATOM   1886 N NE2 . HIS A 1 268 ? 27.86707  10.84864  22.70260 1.000 44.07864  ? 276 HIS A NE2 1 
ATOM   1887 N N   . LEU A 1 269 ? 27.13583  7.76719   19.33873 1.000 42.67140  ? 277 LEU A N   1 
ATOM   1888 C CA  . LEU A 1 269 ? 28.14181  6.79353   18.91702 1.000 45.22557  ? 277 LEU A CA  1 
ATOM   1889 C C   . LEU A 1 269 ? 28.81222  6.08121   20.08393 1.000 42.80674  ? 277 LEU A C   1 
ATOM   1890 O O   . LEU A 1 269 ? 29.50759  5.08452   19.86281 1.000 47.94005  ? 277 LEU A O   1 
ATOM   1891 C CB  . LEU A 1 269 ? 29.20239  7.44985   18.03377 1.000 46.97780  ? 277 LEU A CB  1 
ATOM   1892 C CG  . LEU A 1 269 ? 28.68192  7.99665   16.69739 1.000 54.16751  ? 277 LEU A CG  1 
ATOM   1893 C CD1 . LEU A 1 269 ? 29.66916  9.01511   16.08866 1.000 55.69672  ? 277 LEU A CD1 1 
ATOM   1894 C CD2 . LEU A 1 269 ? 28.33148  6.87040   15.71437 1.000 54.88970  ? 277 LEU A CD2 1 
ATOM   1895 N N   . GLU A 1 270 ? 28.62887  6.54865   21.30202 1.000 44.20941  ? 278 GLU A N   1 
ATOM   1896 C CA  . GLU A 1 270 ? 29.18607  5.81219   22.42540 1.000 46.76038  ? 278 GLU A CA  1 
ATOM   1897 C C   . GLU A 1 270 ? 28.23648  5.92308   23.61304 1.000 44.79238  ? 278 GLU A C   1 
ATOM   1898 O O   . GLU A 1 270 ? 27.25822  6.68062   23.54515 1.000 45.57642  ? 278 GLU A O   1 
ATOM   1899 C CB  . GLU A 1 270 ? 30.58401  6.33472   22.76422 1.000 45.03950  ? 278 GLU A CB  1 
ATOM   1900 C CG  . GLU A 1 270 ? 30.66992  7.79532   23.11743 1.000 49.25226  ? 278 GLU A CG  1 
ATOM   1901 C CD  . GLU A 1 270 ? 32.11673  8.27931   23.13239 1.000 54.36861  ? 278 GLU A CD  1 
ATOM   1902 O OE1 . GLU A 1 270 ? 32.90759  7.77095   22.31691 1.000 59.30835  ? 278 GLU A OE1 1 
ATOM   1903 O OE2 . GLU A 1 270 ? 32.47922  9.12692   23.97579 1.000 55.85024  ? 278 GLU A OE2 1 
ATOM   1904 N N   . PRO A 1 271 ? 28.45758  5.17421   24.69582 1.000 44.59048  ? 279 PRO A N   1 
ATOM   1905 C CA  . PRO A 1 271 ? 27.65208  5.39198   25.90037 1.000 45.50470  ? 279 PRO A CA  1 
ATOM   1906 C C   . PRO A 1 271 ? 27.73000  6.83659   26.35853 1.000 46.48595  ? 279 PRO A C   1 
ATOM   1907 O O   . PRO A 1 271 ? 28.79303  7.46355   26.32806 1.000 44.58837  ? 279 PRO A O   1 
ATOM   1908 C CB  . PRO A 1 271 ? 28.28547  4.44883   26.92755 1.000 40.67598  ? 279 PRO A CB  1 
ATOM   1909 C CG  . PRO A 1 271 ? 28.79682  3.32187   26.09204 1.000 42.49553  ? 279 PRO A CG  1 
ATOM   1910 C CD  . PRO A 1 271 ? 29.27976  3.95304   24.80913 1.000 43.68732  ? 279 PRO A CD  1 
ATOM   1911 N N   . LEU A 1 272 ? 26.57911  7.35068   26.79654 1.000 43.38210  ? 280 LEU A N   1 
ATOM   1912 C CA  . LEU A 1 272 ? 26.48131  8.69080   27.36013 1.000 40.36157  ? 280 LEU A CA  1 
ATOM   1913 C C   . LEU A 1 272 ? 25.30721  8.68973   28.32945 1.000 40.90833  ? 280 LEU A C   1 
ATOM   1914 O O   . LEU A 1 272 ? 24.14839  8.62054   27.90424 1.000 41.15325  ? 280 LEU A O   1 
ATOM   1915 C CB  . LEU A 1 272 ? 26.29061  9.72170   26.25892 1.000 38.05196  ? 280 LEU A CB  1 
ATOM   1916 C CG  . LEU A 1 272 ? 26.04158  11.15725  26.70606 1.000 39.97905  ? 280 LEU A CG  1 
ATOM   1917 C CD1 . LEU A 1 272 ? 27.11807  11.62286  27.67171 1.000 41.90952  ? 280 LEU A CD1 1 
ATOM   1918 C CD2 . LEU A 1 272 ? 25.95645  12.03241  25.47734 1.000 37.76789  ? 280 LEU A CD2 1 
ATOM   1919 N N   . HIS A 1 273 ? 25.60600  8.73106   29.62429 1.000 37.69766  ? 281 HIS A N   1 
ATOM   1920 C CA  . HIS A 1 273 ? 24.55430  8.75684   30.62809 1.000 43.62096  ? 281 HIS A CA  1 
ATOM   1921 C C   . HIS A 1 273 ? 23.70713  10.01679  30.45906 1.000 45.68711  ? 281 HIS A C   1 
ATOM   1922 O O   . HIS A 1 273 ? 24.22364  11.10754  30.20048 1.000 44.58114  ? 281 HIS A O   1 
ATOM   1923 C CB  . HIS A 1 273 ? 25.16477  8.69824   32.01996 1.000 39.02715  ? 281 HIS A CB  1 
ATOM   1924 C CG  . HIS A 1 273 ? 24.16406  8.58449   33.12330 1.000 43.26696  ? 281 HIS A CG  1 
ATOM   1925 N ND1 . HIS A 1 273 ? 23.41349  7.44752   33.33877 1.000 41.63806  ? 281 HIS A ND1 1 
ATOM   1926 C CD2 . HIS A 1 273 ? 23.78637  9.47334   34.07279 1.000 44.94373  ? 281 HIS A CD2 1 
ATOM   1927 C CE1 . HIS A 1 273 ? 22.62479  7.63880   34.38171 1.000 44.66642  ? 281 HIS A CE1 1 
ATOM   1928 N NE2 . HIS A 1 273 ? 22.83291  8.85966   34.84497 1.000 46.94595  ? 281 HIS A NE2 1 
ATOM   1929 N N   . ILE A 1 274 ? 22.39325  9.88496   30.59606 1.000 42.75322  ? 282 ILE A N   1 
ATOM   1930 C CA  . ILE A 1 274 ? 21.52241  11.03771  30.40422 1.000 43.69785  ? 282 ILE A CA  1 
ATOM   1931 C C   . ILE A 1 274 ? 21.18481  11.73309  31.71750 1.000 44.18725  ? 282 ILE A C   1 
ATOM   1932 O O   . ILE A 1 274 ? 21.19682  12.96118  31.77195 1.000 52.75738  ? 282 ILE A O   1 
ATOM   1933 C CB  . ILE A 1 274 ? 20.25509  10.65326  29.62390 1.000 40.83524  ? 282 ILE A CB  1 
ATOM   1934 C CG1 . ILE A 1 274 ? 20.64696  10.42561  28.16088 1.000 37.31645  ? 282 ILE A CG1 1 
ATOM   1935 C CG2 . ILE A 1 274 ? 19.25014  11.78505  29.72388 1.000 42.93302  ? 282 ILE A CG2 1 
ATOM   1936 C CD1 . ILE A 1 274 ? 19.57567  9.78279   27.31349 1.000 37.18803  ? 282 ILE A CD1 1 
ATOM   1937 N N   . SER A 1 275 ? 20.88425  10.97925  32.76853 1.000 41.82903  ? 283 SER A N   1 
ATOM   1938 C CA  . SER A 1 275 ? 20.61159  11.50345  34.11130 1.000 48.65636  ? 283 SER A CA  1 
ATOM   1939 C C   . SER A 1 275 ? 19.12446  11.75191  34.29119 1.000 43.41178  ? 283 SER A C   1 
ATOM   1940 O O   . SER A 1 275 ? 18.41649  12.10955  33.34206 1.000 40.35061  ? 283 SER A O   1 
ATOM   1941 C CB  . SER A 1 275 ? 21.39446  12.78153  34.45268 1.000 48.50348  ? 283 SER A CB  1 
ATOM   1942 O OG  . SER A 1 275 ? 20.63512  13.94430  34.15926 1.000 51.80991  ? 283 SER A OG  1 
ATOM   1943 N N   . HIS A 1 276 ? 18.65509  11.55876  35.52081 1.000 45.38178  ? 284 HIS A N   1 
ATOM   1944 C CA  . HIS A 1 276 ? 17.22950  11.36342  35.74125 1.000 47.98935  ? 284 HIS A CA  1 
ATOM   1945 C C   . HIS A 1 276 ? 16.44551  12.64376  35.45416 1.000 45.88570  ? 284 HIS A C   1 
ATOM   1946 O O   . HIS A 1 276 ? 15.39977  12.59214  34.79734 1.000 43.18143  ? 284 HIS A O   1 
ATOM   1947 C CB  . HIS A 1 276 ? 17.00414  10.86647  37.16910 1.000 54.53841  ? 284 HIS A CB  1 
ATOM   1948 C CG  . HIS A 1 276 ? 15.58917  10.47746  37.46212 1.000 59.38863  ? 284 HIS A CG  1 
ATOM   1949 N ND1 . HIS A 1 276 ? 15.07646  9.23890   37.13268 1.000 68.14049  ? 284 HIS A ND1 1 
ATOM   1950 C CD2 . HIS A 1 276 ? 14.57882  11.15744  38.05423 1.000 59.41175  ? 284 HIS A CD2 1 
ATOM   1951 C CE1 . HIS A 1 276 ? 13.81129  9.17125   37.50896 1.000 64.29940  ? 284 HIS A CE1 1 
ATOM   1952 N NE2 . HIS A 1 276 ? 13.48210  10.32545  38.06397 1.000 70.98747  ? 284 HIS A NE2 1 
ATOM   1953 N N   . GLU A 1 277 ? 16.96162  13.79499  35.92186 1.000 42.79388  ? 285 GLU A N   1 
ATOM   1954 C CA  . GLU A 1 277 ? 16.35925  15.10916  35.67247 1.000 44.56189  ? 285 GLU A CA  1 
ATOM   1955 C C   . GLU A 1 277 ? 15.98880  15.30282  34.20930 1.000 42.06283  ? 285 GLU A C   1 
ATOM   1956 O O   . GLU A 1 277 ? 14.85255  15.67048  33.89192 1.000 39.86201  ? 285 GLU A O   1 
ATOM   1957 C CB  . GLU A 1 277 ? 17.32787  16.21417  36.12396 1.000 46.73110  ? 285 GLU A CB  1 
ATOM   1958 C CG  . GLU A 1 277 ? 18.82582  15.85141  35.81356 1.000 56.16147  ? 285 GLU A CG  1 
ATOM   1959 C CD  . GLU A 1 277 ? 19.77706  17.05221  35.72141 1.000 62.60047  ? 285 GLU A CD  1 
ATOM   1960 O OE1 . GLU A 1 277 ? 19.69457  17.94876  36.59993 1.000 66.42375  ? 285 GLU A OE1 1 
ATOM   1961 O OE2 . GLU A 1 277 ? 20.64962  17.06246  34.80654 1.000 59.48726  ? 285 GLU A OE2 1 
ATOM   1962 N N   . ARG A 1 278 ? 16.94080  15.04973  33.29881 1.000 41.37644  ? 286 ARG A N   1 
ATOM   1963 C CA  . ARG A 1 278 ? 16.73593  15.30986  31.87152 1.000 43.29879  ? 286 ARG A CA  1 
ATOM   1964 C C   . ARG A 1 278 ? 15.93382  14.19523  31.20345 1.000 38.29466  ? 286 ARG A C   1 
ATOM   1965 O O   . ARG A 1 278 ? 15.19813  14.45146  30.23834 1.000 39.15899  ? 286 ARG A O   1 
ATOM   1966 C CB  . ARG A 1 278 ? 18.10476  15.53950  31.18094 1.000 37.70562  ? 286 ARG A CB  1 
ATOM   1967 C CG  . ARG A 1 278 ? 18.78666  16.94443  31.42859 1.000 45.11343  ? 286 ARG A CG  1 
ATOM   1968 C CD  . ARG A 1 278 ? 20.32673  16.96698  31.12490 1.000 51.28268  ? 286 ARG A CD  1 
ATOM   1969 N NE  . ARG A 1 278 ? 20.97834  18.16547  30.57091 1.000 54.43441  ? 286 ARG A NE  1 
ATOM   1970 C CZ  . ARG A 1 278 ? 20.89703  19.42286  31.01718 1.000 56.21190  ? 286 ARG A CZ  1 
ATOM   1971 N NH1 . ARG A 1 278 ? 20.08225  19.77071  32.00970 1.000 54.34858  ? 286 ARG A NH1 1 
ATOM   1972 N NH2 . ARG A 1 278 ? 21.68382  20.35911  30.47274 1.000 42.41173  ? 286 ARG A NH2 1 
ATOM   1973 N N   . ARG A 1 279 ? 15.99373  12.98172  31.74248 1.000 37.58164  ? 287 ARG A N   1 
ATOM   1974 C CA  . ARG A 1 279 ? 15.06744  11.93455  31.31511 1.000 38.68984  ? 287 ARG A CA  1 
ATOM   1975 C C   . ARG A 1 279 ? 13.62645  12.29609  31.66820 1.000 37.35198  ? 287 ARG A C   1 
ATOM   1976 O O   . ARG A 1 279 ? 12.72940  12.18100  30.83262 1.000 32.11349  ? 287 ARG A O   1 
ATOM   1977 C CB  . ARG A 1 279 ? 15.45172  10.60943  31.95958 1.000 37.82372  ? 287 ARG A CB  1 
ATOM   1978 C CG  . ARG A 1 279 ? 16.72838  9.97902   31.43207 1.000 44.72670  ? 287 ARG A CG  1 
ATOM   1979 C CD  . ARG A 1 279 ? 16.73196  8.49389   31.70794 1.000 45.06845  ? 287 ARG A CD  1 
ATOM   1980 N NE  . ARG A 1 279 ? 18.07480  8.08341   32.09168 1.000 52.97327  ? 287 ARG A NE  1 
ATOM   1981 C CZ  . ARG A 1 279 ? 18.40226  6.93650   32.67420 1.000 52.85109  ? 287 ARG A CZ  1 
ATOM   1982 N NH1 . ARG A 1 279 ? 17.49127  6.02299   32.97901 1.000 50.01463  ? 287 ARG A NH1 1 
ATOM   1983 N NH2 . ARG A 1 279 ? 19.67939  6.70330   32.95856 1.000 48.53929  ? 287 ARG A NH2 1 
ATOM   1984 N N   . ARG A 1 280 ? 13.39160  12.73156  32.90936 1.000 34.12181  ? 288 ARG A N   1 
ATOM   1985 C CA  . ARG A 1 280 ? 12.05194  13.14121  33.33987 1.000 38.83596  ? 288 ARG A CA  1 
ATOM   1986 C C   . ARG A 1 280 ? 11.52143  14.32057  32.51367 1.000 37.95277  ? 288 ARG A C   1 
ATOM   1987 O O   . ARG A 1 280 ? 10.34569  14.34783  32.12490 1.000 36.32940  ? 288 ARG A O   1 
ATOM   1988 C CB  . ARG A 1 280 ? 12.10979  13.46661  34.83706 1.000 40.89596  ? 288 ARG A CB  1 
ATOM   1989 C CG  . ARG A 1 280 ? 11.11969  14.46986  35.34152 1.000 46.92476  ? 288 ARG A CG  1 
ATOM   1990 C CD  . ARG A 1 280 ? 9.74163   13.85659  35.61609 1.000 54.49502  ? 288 ARG A CD  1 
ATOM   1991 N NE  . ARG A 1 280 ? 8.93264   14.74351  36.45270 1.000 56.11790  ? 288 ARG A NE  1 
ATOM   1992 C CZ  . ARG A 1 280 ? 7.60831   14.82572  36.41732 1.000 58.65971  ? 288 ARG A CZ  1 
ATOM   1993 N NH1 . ARG A 1 280 ? 6.88556   14.05392  35.61500 1.000 61.21065  ? 288 ARG A NH1 1 
ATOM   1994 N NH2 . ARG A 1 280 ? 6.99339   15.73534  37.17565 1.000 62.19284  ? 288 ARG A NH2 1 
ATOM   1995 N N   . ALA A 1 281 ? 12.37942  15.29863  32.21398 1.000 40.55455  ? 289 ALA A N   1 
ATOM   1996 C CA  . ALA A 1 281 ? 11.98711  16.38402  31.31568 1.000 38.77777  ? 289 ALA A CA  1 
ATOM   1997 C C   . ALA A 1 281 ? 11.61871  15.85482  29.92979 1.000 40.03669  ? 289 ALA A C   1 
ATOM   1998 O O   . ALA A 1 281 ? 10.69550  16.36999  29.28235 1.000 39.44373  ? 289 ALA A O   1 
ATOM   1999 C CB  . ALA A 1 281 ? 13.12114  17.40399  31.21557 1.000 38.38702  ? 289 ALA A CB  1 
ATOM   2000 N N   . CYS A 1 282 ? 12.31953  14.81320  29.46847 1.000 35.95489  ? 290 CYS A N   1 
ATOM   2001 C CA  . CYS A 1 282 ? 12.01288  14.19937  28.17735 1.000 34.70821  ? 290 CYS A CA  1 
ATOM   2002 C C   . CYS A 1 282 ? 10.61781  13.59240  28.16310 1.000 35.67519  ? 290 CYS A C   1 
ATOM   2003 O O   . CYS A 1 282 ? 9.87370   13.74274  27.18271 1.000 33.68185  ? 290 CYS A O   1 
ATOM   2004 C CB  . CYS A 1 282 ? 13.03883  13.11830  27.87052 1.000 37.55832  ? 290 CYS A CB  1 
ATOM   2005 S SG  . CYS A 1 282 ? 14.51048  13.74158  27.05554 1.000 38.00912  ? 290 CYS A SG  1 
ATOM   2006 N N   . GLU A 1 283 ? 10.25174  12.89591  29.24052 1.000 32.08281  ? 291 GLU A N   1 
ATOM   2007 C CA  . GLU A 1 283 ? 8.92966   12.27784  29.32702 1.000 38.98666  ? 291 GLU A CA  1 
ATOM   2008 C C   . GLU A 1 283 ? 7.82537   13.33035  29.43441 1.000 38.51603  ? 291 GLU A C   1 
ATOM   2009 O O   . GLU A 1 283 ? 6.75756   13.19451  28.81913 1.000 42.34818  ? 291 GLU A O   1 
ATOM   2010 C CB  . GLU A 1 283 ? 8.90079   11.30332  30.50162 1.000 35.03790  ? 291 GLU A CB  1 
ATOM   2011 C CG  . GLU A 1 283 ? 7.59118   10.52316  30.65027 1.000 42.74867  ? 291 GLU A CG  1 
ATOM   2012 C CD  . GLU A 1 283 ? 7.73115   9.32187   31.59406 1.000 50.11764  ? 291 GLU A CD  1 
ATOM   2013 O OE1 . GLU A 1 283 ? 8.77008   8.62867   31.53081 1.000 53.43589  ? 291 GLU A OE1 1 
ATOM   2014 O OE2 . GLU A 1 283 ? 6.81975   9.06066   32.40085 1.000 53.22502  ? 291 GLU A OE2 1 
ATOM   2015 N N   . VAL A 1 284 ? 8.05802   14.38578  30.20702 1.000 36.19130  ? 292 VAL A N   1 
ATOM   2016 C CA  . VAL A 1 284 ? 7.07637   15.46069  30.27759 1.000 39.01000  ? 292 VAL A CA  1 
ATOM   2017 C C   . VAL A 1 284 ? 6.84464   16.05813  28.89176 1.000 40.68571  ? 292 VAL A C   1 
ATOM   2018 O O   . VAL A 1 284 ? 5.70063   16.31011  28.48526 1.000 37.28973  ? 292 VAL A O   1 
ATOM   2019 C CB  . VAL A 1 284 ? 7.53364   16.51018  31.30279 1.000 37.85114  ? 292 VAL A CB  1 
ATOM   2020 C CG1 . VAL A 1 284 ? 6.80707   17.82426  31.07567 1.000 36.69864  ? 292 VAL A CG1 1 
ATOM   2021 C CG2 . VAL A 1 284 ? 7.27306   15.97579  32.71196 1.000 35.53016  ? 292 VAL A CG2 1 
ATOM   2022 N N   . LEU A 1 285 ? 7.91573   16.21387  28.11432 1.000 35.83938  ? 293 LEU A N   1 
ATOM   2023 C CA  . LEU A 1 285 ? 7.78034   16.73852  26.76249 1.000 34.99972  ? 293 LEU A CA  1 
ATOM   2024 C C   . LEU A 1 285 ? 6.90542   15.83825  25.89132 1.000 37.90581  ? 293 LEU A C   1 
ATOM   2025 O O   . LEU A 1 285 ? 6.10440   16.33488  25.08654 1.000 38.30777  ? 293 LEU A O   1 
ATOM   2026 C CB  . LEU A 1 285 ? 9.16606   16.93087  26.14358 1.000 34.55781  ? 293 LEU A CB  1 
ATOM   2027 C CG  . LEU A 1 285 ? 9.12519   17.36959  24.68174 1.000 36.20684  ? 293 LEU A CG  1 
ATOM   2028 C CD1 . LEU A 1 285 ? 8.60332   18.80275  24.55465 1.000 33.12570  ? 293 LEU A CD1 1 
ATOM   2029 C CD2 . LEU A 1 285 ? 10.49070  17.21566  24.03598 1.000 34.36834  ? 293 LEU A CD2 1 
ATOM   2030 N N   . THR A 1 286 ? 7.03619   14.51249  26.03051 1.000 33.83175  ? 294 THR A N   1 
ATOM   2031 C CA  . THR A 1 286 ? 6.13378   13.62888  25.28796 1.000 39.02000  ? 294 THR A CA  1 
ATOM   2032 C C   . THR A 1 286 ? 4.67848   13.77044  25.74658 1.000 35.39502  ? 294 THR A C   1 
ATOM   2033 O O   . THR A 1 286 ? 3.76213   13.62162  24.93075 1.000 37.75058  ? 294 THR A O   1 
ATOM   2034 C CB  . THR A 1 286 ? 6.58583   12.15786  25.39195 1.000 38.72169  ? 294 THR A CB  1 
ATOM   2035 O OG1 . THR A 1 286 ? 6.38478   11.65909  26.72111 1.000 41.30851  ? 294 THR A OG1 1 
ATOM   2036 C CG2 . THR A 1 286 ? 8.05006   12.00421  24.99604 1.000 36.71250  ? 294 THR A CG2 1 
ATOM   2037 N N   . GLN A 1 287 ? 4.43651   14.03527  27.03463 1.000 37.79028  ? 295 GLN A N   1 
ATOM   2038 C CA  . GLN A 1 287 ? 3.06674   14.31262  27.48413 1.000 38.70342  ? 295 GLN A CA  1 
ATOM   2039 C C   . GLN A 1 287 ? 2.55013   15.64539  26.94490 1.000 37.11116  ? 295 GLN A C   1 
ATOM   2040 O O   . GLN A 1 287 ? 1.39112   15.74016  26.52728 1.000 38.87425  ? 295 GLN A O   1 
ATOM   2041 C CB  . GLN A 1 287 ? 2.99044   14.27982  29.01369 1.000 40.58089  ? 295 GLN A CB  1 
ATOM   2042 C CG  . GLN A 1 287 ? 3.13351   12.87429  29.59329 1.000 43.39831  ? 295 GLN A CG  1 
ATOM   2043 C CD  . GLN A 1 287 ? 3.60545   12.85415  31.04917 1.000 52.82467  ? 295 GLN A CD  1 
ATOM   2044 O OE1 . GLN A 1 287 ? 3.82201   13.90050  31.66461 1.000 52.83651  ? 295 GLN A OE1 1 
ATOM   2045 N NE2 . GLN A 1 287 ? 3.79372   11.65057  31.59545 1.000 54.90884  ? 295 GLN A NE2 1 
ATOM   2046 N N   . LEU A 1 288 ? 3.37901   16.69569  26.98187 1.000 33.95458  ? 296 LEU A N   1 
ATOM   2047 C CA  . LEU A 1 288 ? 2.99559   17.97818  26.39803 1.000 33.31350  ? 296 LEU A CA  1 
ATOM   2048 C C   . LEU A 1 288 ? 2.73306   17.84546  24.90543 1.000 38.21977  ? 296 LEU A C   1 
ATOM   2049 O O   . LEU A 1 288 ? 1.80930   18.47075  24.37299 1.000 37.80986  ? 296 LEU A O   1 
ATOM   2050 C CB  . LEU A 1 288 ? 4.08669   19.03065  26.64278 1.000 38.47079  ? 296 LEU A CB  1 
ATOM   2051 C CG  . LEU A 1 288 ? 4.39890   19.32691  28.10630 1.000 33.91933  ? 296 LEU A CG  1 
ATOM   2052 C CD1 . LEU A 1 288 ? 5.61428   20.24899  28.23835 1.000 35.87899  ? 296 LEU A CD1 1 
ATOM   2053 C CD2 . LEU A 1 288 ? 3.16826   19.92422  28.75624 1.000 32.47710  ? 296 LEU A CD2 1 
ATOM   2054 N N   . LEU A 1 289 ? 3.55577   17.06896  24.19675 1.000 34.51021  ? 297 LEU A N   1 
ATOM   2055 C CA  . LEU A 1 289 ? 3.32245   16.91769  22.76229 1.000 38.35344  ? 297 LEU A CA  1 
ATOM   2056 C C   . LEU A 1 289 ? 2.02921   16.15931  22.48501 1.000 42.42751  ? 297 LEU A C   1 
ATOM   2057 O O   . LEU A 1 289 ? 1.34850   16.45861  21.50236 1.000 44.84123  ? 297 LEU A O   1 
ATOM   2058 C CB  . LEU A 1 289 ? 4.51398   16.22862  22.08389 1.000 37.46150  ? 297 LEU A CB  1 
ATOM   2059 C CG  . LEU A 1 289 ? 5.84052   17.01766  22.06190 1.000 38.72695  ? 297 LEU A CG  1 
ATOM   2060 C CD1 . LEU A 1 289 ? 7.00214   16.19076  21.47933 1.000 35.72522  ? 297 LEU A CD1 1 
ATOM   2061 C CD2 . LEU A 1 289 ? 5.69687   18.34374  21.31765 1.000 33.60955  ? 297 LEU A CD2 1 
ATOM   2062 N N   . ALA A 1 290 ? 1.67796   15.17926  23.32913 1.000 39.76251  ? 298 ALA A N   1 
ATOM   2063 C CA  . ALA A 1 290 ? 0.44063   14.42837  23.13022 1.000 41.14396  ? 298 ALA A CA  1 
ATOM   2064 C C   . ALA A 1 290 ? -0.77904  15.33355  23.25736 1.000 48.58233  ? 298 ALA A C   1 
ATOM   2065 O O   . ALA A 1 290 ? -1.75911  15.18694  22.51542 1.000 50.31813  ? 298 ALA A O   1 
ATOM   2066 C CB  . ALA A 1 290 ? 0.36151   13.28336  24.13939 1.000 40.58569  ? 298 ALA A CB  1 
ATOM   2067 N N   . LEU A 1 291 ? -0.72988  16.28072  24.19244 1.000 46.08712  ? 299 LEU A N   1 
ATOM   2068 C CA  . LEU A 1 291 ? -1.80520  17.25356  24.33858 1.000 48.47486  ? 299 LEU A CA  1 
ATOM   2069 C C   . LEU A 1 291 ? -1.94795  18.08586  23.06983 1.000 54.62360  ? 299 LEU A C   1 
ATOM   2070 O O   . LEU A 1 291 ? -3.05138  18.26408  22.53888 1.000 52.66130  ? 299 LEU A O   1 
ATOM   2071 C CB  . LEU A 1 291 ? -1.49375  18.15239  25.52971 1.000 49.21457  ? 299 LEU A CB  1 
ATOM   2072 C CG  . LEU A 1 291 ? -1.97098  17.76116  26.92290 1.000 52.06616  ? 299 LEU A CG  1 
ATOM   2073 C CD1 . LEU A 1 291 ? -1.84534  18.98180  27.81949 1.000 54.31931  ? 299 LEU A CD1 1 
ATOM   2074 C CD2 . LEU A 1 291 ? -3.37916  17.21001  26.90999 1.000 53.28038  ? 299 LEU A CD2 1 
ATOM   2075 N N   . GLN A 1 292 ? -0.81877  18.58813  22.56177 1.000 50.40343  ? 300 GLN A N   1 
ATOM   2076 C CA  . GLN A 1 292 ? -0.82295  19.45228  21.38821 1.000 51.65794  ? 300 GLN A CA  1 
ATOM   2077 C C   . GLN A 1 292 ? -1.30612  18.72292  20.14054 1.000 55.87297  ? 300 GLN A C   1 
ATOM   2078 O O   . GLN A 1 292 ? -1.89644  19.34899  19.25310 1.000 61.44248  ? 300 GLN A O   1 
ATOM   2079 C CB  . GLN A 1 292 ? 0.57811   20.01825  21.16865 1.000 49.89092  ? 300 GLN A CB  1 
ATOM   2080 C CG  . GLN A 1 292 ? 0.65826   20.96755  20.01341 1.000 54.19945  ? 300 GLN A CG  1 
ATOM   2081 C CD  . GLN A 1 292 ? -0.29799  22.11843  20.18192 1.000 56.58083  ? 300 GLN A CD  1 
ATOM   2082 O OE1 . GLN A 1 292 ? -1.23149  22.27166  19.39927 1.000 62.35008  ? 300 GLN A OE1 1 
ATOM   2083 N NE2 . GLN A 1 292 ? -0.06094  22.94642  21.18914 1.000 58.66788  ? 300 GLN A NE2 1 
ATOM   2084 N N   . LEU A 1 293 ? -1.04602  17.41104  20.04120 1.000 54.02640  ? 301 LEU A N   1 
ATOM   2085 C CA  . LEU A 1 293 ? -1.47297  16.63077  18.88054 1.000 55.92121  ? 301 LEU A CA  1 
ATOM   2086 C C   . LEU A 1 293 ? -2.96420  16.30861  18.91128 1.000 60.75359  ? 301 LEU A C   1 
ATOM   2087 O O   . LEU A 1 293 ? -3.58736  16.17915  17.85176 1.000 64.41040  ? 301 LEU A O   1 
ATOM   2088 C CB  . LEU A 1 293 ? -0.67762  15.32745  18.79174 1.000 52.46190  ? 301 LEU A CB  1 
ATOM   2089 C CG  . LEU A 1 293 ? 0.81972   15.43880  18.51027 1.000 48.67269  ? 301 LEU A CG  1 
ATOM   2090 C CD1 . LEU A 1 293 ? 1.48527   14.07929  18.57548 1.000 45.92170  ? 301 LEU A CD1 1 
ATOM   2091 C CD2 . LEU A 1 293 ? 1.02801   16.08755  17.15215 1.000 51.09389  ? 301 LEU A CD2 1 
ATOM   2092 N N   . SER A 1 294 ? -3.54760  16.18917  20.10246 1.000 61.05086  ? 302 SER A N   1 
ATOM   2093 C CA  . SER A 1 294 ? -4.95567  15.84557  20.26755 1.000 65.70545  ? 302 SER A CA  1 
ATOM   2094 C C   . SER A 1 294 ? -5.82385  17.08988  20.27849 1.000 74.39858  ? 302 SER A C   1 
ATOM   2095 O O   . SER A 1 294 ? -6.82001  17.16696  19.55387 1.000 84.71824  ? 302 SER A O   1 
ATOM   2096 C CB  . SER A 1 294 ? -5.16924  15.07739  21.57498 1.000 63.88735  ? 302 SER A CB  1 
ATOM   2097 O OG  . SER A 1 294 ? -4.21814  14.03748  21.73203 1.000 61.64836  ? 302 SER A OG  1 
ATOM   2098 N N   . ALA A 1 295 ? -5.44878  18.07098  21.09847 1.000 75.72287  ? 303 ALA A N   1 
ATOM   2099 C CA  . ALA A 1 295 ? -6.21928  19.29946  21.21817 1.000 87.15469  ? 303 ALA A CA  1 
ATOM   2100 C C   . ALA A 1 295 ? -6.28522  20.08867  19.91774 1.000 93.71498  ? 303 ALA A C   1 
ATOM   2101 O O   . ALA A 1 295 ? -7.15253  20.96629  19.79605 1.000 98.57183  ? 303 ALA A O   1 
ATOM   2102 C CB  . ALA A 1 295 ? -5.62218  20.18244  22.32195 1.000 80.19533  ? 303 ALA A CB  1 
ATOM   2103 N N   . GLU A 1 296 ? -5.42591  19.77970  18.93565 1.000 88.45933  ? 304 GLU A N   1 
ATOM   2104 C CA  . GLU A 1 296 ? -5.45361  20.50927  17.67125 1.000 94.64218  ? 304 GLU A CA  1 
ATOM   2105 C C   . GLU A 1 296 ? -6.79986  20.36854  16.95860 1.000 101.21238 ? 304 GLU A C   1 
ATOM   2106 O O   . GLU A 1 296 ? -7.16468  21.24121  16.15747 1.000 102.94409 ? 304 GLU A O   1 
ATOM   2107 C CB  . GLU A 1 296 ? -4.30190  20.03833  16.77053 1.000 88.10703  ? 304 GLU A CB  1 
ATOM   2108 C CG  . GLU A 1 296 ? -3.79122  21.11261  15.81072 1.000 95.55508  ? 304 GLU A CG  1 
ATOM   2109 C CD  . GLU A 1 296 ? -4.26916  20.92553  14.38052 1.000 101.89808 ? 304 GLU A CD  1 
ATOM   2110 O OE1 . GLU A 1 296 ? -4.69071  19.80125  14.03167 1.000 105.27569 ? 304 GLU A OE1 1 
ATOM   2111 O OE2 . GLU A 1 296 ? -4.23313  21.91066  13.60870 1.000 101.56023 ? 304 GLU A OE2 1 
ATOM   2112 N N   . GLU A 1 297 ? -7.55592  19.30575  17.24962 1.000 100.01949 ? 305 GLU A N   1 
ATOM   2113 C CA  . GLU A 1 297 ? -8.91696  19.17919  16.74231 1.000 101.87306 ? 305 GLU A CA  1 
ATOM   2114 C C   . GLU A 1 297 ? -9.89878  19.64471  17.81345 1.000 104.77285 ? 305 GLU A C   1 
ATOM   2115 O O   . GLU A 1 297 ? -10.45585 20.74519  17.71936 1.000 105.93317 ? 305 GLU A O   1 
ATOM   2116 C CB  . GLU A 1 297 ? -9.22016  17.73929  16.30342 1.000 100.12653 ? 305 GLU A CB  1 
ATOM   2117 C CG  . GLU A 1 297 ? -8.40727  17.26624  15.09803 1.000 96.90821  ? 305 GLU A CG  1 
ATOM   2118 C CD  . GLU A 1 297 ? -7.12204  16.55106  15.48695 1.000 94.16810  ? 305 GLU A CD  1 
ATOM   2119 O OE1 . GLU A 1 297 ? -7.20800  15.53146  16.21061 1.000 85.42498  ? 305 GLU A OE1 1 
ATOM   2120 O OE2 . GLU A 1 297 ? -6.02818  17.01094  15.07805 1.000 96.54773  ? 305 GLU A OE2 1 
ATOM   2121 N N   . ARG A 1 298 ? -10.11840 18.81933  18.83328 1.000 106.89892 ? 306 ARG A N   1 
ATOM   2122 C CA  . ARG A 1 298 ? -11.00377 19.19631  19.93318 1.000 111.95884 ? 306 ARG A CA  1 
ATOM   2123 C C   . ARG A 1 298 ? -10.22037 19.94113  21.01728 1.000 108.13272 ? 306 ARG A C   1 
ATOM   2124 O O   . ARG A 1 298 ? -9.33060  19.37681  21.66303 1.000 102.85284 ? 306 ARG A O   1 
ATOM   2125 C CB  . ARG A 1 298 ? -11.69265 17.96608  20.53202 1.000 113.97382 ? 306 ARG A CB  1 
ATOM   2126 C CG  . ARG A 1 298 ? -12.84703 18.30255  21.46110 1.000 115.82823 ? 306 ARG A CG  1 
ATOM   2127 C CD  . ARG A 1 298 ? -13.11522 17.16726  22.43319 1.000 121.58198 ? 306 ARG A CD  1 
ATOM   2128 N NE  . ARG A 1 298 ? -11.97116 16.93927  23.30834 1.000 121.02801 ? 306 ARG A NE  1 
ATOM   2129 C CZ  . ARG A 1 298 ? -11.72870 17.63265  24.41197 1.000 120.18630 ? 306 ARG A CZ  1 
ATOM   2130 N NH1 . ARG A 1 298 ? -12.53594 18.60406  24.80777 1.000 122.44588 ? 306 ARG A NH1 1 
ATOM   2131 N NH2 . ARG A 1 298 ? -10.64771 17.34809  25.13353 1.000 118.87324 ? 306 ARG A NH2 1 
ATOM   2132 N N   . ASP B 1 1   ? -1.51025  4.09395   12.12852 1.000 57.30966  ? 9   ASP B N   1 
ATOM   2133 C CA  . ASP B 1 1   ? -2.79666  3.49643   12.48860 1.000 60.94023  ? 9   ASP B CA  1 
ATOM   2134 C C   . ASP B 1 1   ? -3.36454  2.66324   11.33253 1.000 68.45816  ? 9   ASP B C   1 
ATOM   2135 O O   . ASP B 1 1   ? -2.60324  2.27555   10.46971 1.000 67.25883  ? 9   ASP B O   1 
ATOM   2136 C CB  . ASP B 1 1   ? -3.75964  4.58204   12.90441 1.000 70.74466  ? 9   ASP B CB  1 
ATOM   2137 C CG  . ASP B 1 1   ? -3.45600  5.12925   14.28292 1.000 70.47502  ? 9   ASP B CG  1 
ATOM   2138 O OD1 . ASP B 1 1   ? -3.21141  4.31677   15.20558 1.000 66.06075  ? 9   ASP B OD1 1 
ATOM   2139 O OD2 . ASP B 1 1   ? -3.46375  6.37539   14.44030 1.000 70.40360  ? 9   ASP B OD2 1 
ATOM   2140 N N   . LEU B 1 2   ? -4.67092  2.32755   11.31570 1.000 74.94471  ? 10  LEU B N   1 
ATOM   2141 C CA  . LEU B 1 2   ? -5.17286  1.54353   10.18263 1.000 77.52398  ? 10  LEU B CA  1 
ATOM   2142 C C   . LEU B 1 2   ? -6.58829  1.94900   9.71959  1.000 80.00607  ? 10  LEU B C   1 
ATOM   2143 O O   . LEU B 1 2   ? -7.33189  1.08789   9.23176  1.000 80.11917  ? 10  LEU B O   1 
ATOM   2144 C CB  . LEU B 1 2   ? -5.17202  0.04365   10.53481 1.000 78.24530  ? 10  LEU B CB  1 
ATOM   2145 C CG  . LEU B 1 2   ? -3.92094  -0.73358  10.95645 1.000 74.08274  ? 10  LEU B CG  1 
ATOM   2146 C CD1 . LEU B 1 2   ? -4.33699  -2.00564  11.69810 1.000 61.00386  ? 10  LEU B CD1 1 
ATOM   2147 C CD2 . LEU B 1 2   ? -3.08363  -1.09330  9.72859  1.000 72.56633  ? 10  LEU B CD2 1 
ATOM   2148 N N   . SER B 1 3   ? -6.95827  3.24632   9.84818  1.000 82.32982  ? 11  SER B N   1 
ATOM   2149 C CA  . SER B 1 3   ? -8.15994  3.93025   9.31465  1.000 84.47647  ? 11  SER B CA  1 
ATOM   2150 C C   . SER B 1 3   ? -8.85181  4.84965   10.32749 1.000 84.96316  ? 11  SER B C   1 
ATOM   2151 O O   . SER B 1 3   ? -8.26757  5.22210   11.35316 1.000 79.54065  ? 11  SER B O   1 
ATOM   2152 C CB  . SER B 1 3   ? -9.23799  2.97582   8.76712  1.000 85.01013  ? 11  SER B CB  1 
ATOM   2153 O OG  . SER B 1 3   ? -9.80041  2.16914   9.79031  1.000 83.89925  ? 11  SER B OG  1 
ATOM   2154 N N   . GLN B 1 4   ? -10.10970 5.21974   10.01797 1.000 86.84059  ? 12  GLN B N   1 
ATOM   2155 C CA  . GLN B 1 4   ? -10.94293 6.08253   10.86164 1.000 82.17005  ? 12  GLN B CA  1 
ATOM   2156 C C   . GLN B 1 4   ? -11.29236 5.47297   12.21651 1.000 81.42728  ? 12  GLN B C   1 
ATOM   2157 O O   . GLN B 1 4   ? -11.59258 6.22183   13.15399 1.000 81.19158  ? 12  GLN B O   1 
ATOM   2158 C CB  . GLN B 1 4   ? -12.23485 6.43841   10.11831 1.000 83.56496  ? 12  GLN B CB  1 
ATOM   2159 C CG  . GLN B 1 4   ? -12.03739 7.38579   8.94425  1.000 84.81548  ? 12  GLN B CG  1 
ATOM   2160 C CD  . GLN B 1 4   ? -11.67480 8.78925   9.39652  1.000 86.65397  ? 12  GLN B CD  1 
ATOM   2161 O OE1 . GLN B 1 4   ? -12.38881 9.39848   10.19456 1.000 81.68489  ? 12  GLN B OE1 1 
ATOM   2162 N NE2 . GLN B 1 4   ? -10.55505 9.30486   8.89794  1.000 88.76002  ? 12  GLN B NE2 1 
ATOM   2163 N N   . CYS B 1 5   ? -11.25660 4.13965   12.34784 1.000 80.45468  ? 13  CYS B N   1 
ATOM   2164 C CA  . CYS B 1 5   ? -11.54882 3.45376   13.60441 1.000 70.10166  ? 13  CYS B CA  1 
ATOM   2165 C C   . CYS B 1 5   ? -10.43206 2.54079   14.09408 1.000 72.29452  ? 13  CYS B C   1 
ATOM   2166 O O   . CYS B 1 5   ? -10.54045 1.99796   15.20141 1.000 68.88393  ? 13  CYS B O   1 
ATOM   2167 C CB  . CYS B 1 5   ? -12.83942 2.63443   13.47055 1.000 65.08340  ? 13  CYS B CB  1 
ATOM   2168 S SG  . CYS B 1 5   ? -12.79100 1.43940   12.11471 1.000 73.19626  ? 13  CYS B SG  1 
ATOM   2169 N N   . ASP B 1 6   ? -9.37507  2.34267   13.31526 1.000 72.94638  ? 14  ASP B N   1 
ATOM   2170 C CA  . ASP B 1 6   ? -8.25039  1.53275   13.75735 1.000 70.94040  ? 14  ASP B CA  1 
ATOM   2171 C C   . ASP B 1 6   ? -7.19924  2.34294   14.52922 1.000 66.58820  ? 14  ASP B C   1 
ATOM   2172 O O   . ASP B 1 6   ? -6.11924  1.81841   14.82256 1.000 64.10352  ? 14  ASP B O   1 
ATOM   2173 C CB  . ASP B 1 6   ? -7.63494  0.80810   12.56488 1.000 71.52094  ? 14  ASP B CB  1 
ATOM   2174 C CG  . ASP B 1 6   ? -8.51578  -0.33770  12.04600 1.000 75.12579  ? 14  ASP B CG  1 
ATOM   2175 O OD1 . ASP B 1 6   ? -9.09920  -1.06743  12.87157 1.000 71.75948  ? 14  ASP B OD1 1 
ATOM   2176 O OD2 . ASP B 1 6   ? -8.63965  -0.51528  10.81030 1.000 79.40754  ? 14  ASP B OD2 1 
ATOM   2177 N N   . ARG B 1 7   ? -7.48497  3.61001   14.83923 1.000 65.77262  ? 15  ARG B N   1 
ATOM   2178 C CA  . ARG B 1 7   ? -6.71590  4.38452   15.80658 1.000 59.82596  ? 15  ARG B CA  1 
ATOM   2179 C C   . ARG B 1 7   ? -7.44920  4.48177   17.13962 1.000 57.03001  ? 15  ARG B C   1 
ATOM   2180 O O   . ARG B 1 7   ? -7.02627  5.24000   18.01360 1.000 55.65664  ? 15  ARG B O   1 
ATOM   2181 C CB  . ARG B 1 7   ? -6.46636  5.81113   15.27803 1.000 66.08834  ? 15  ARG B CB  1 
ATOM   2182 C CG  . ARG B 1 7   ? -6.63398  5.96192   13.75271 1.000 75.89742  ? 15  ARG B CG  1 
ATOM   2183 C CD  . ARG B 1 7   ? -6.34568  7.33766   13.10642 1.000 79.45974  ? 15  ARG B CD  1 
ATOM   2184 N NE  . ARG B 1 7   ? -6.07932  7.16140   11.67723 1.000 80.14929  ? 15  ARG B NE  1 
ATOM   2185 C CZ  . ARG B 1 7   ? -5.46680  8.04134   10.89465 1.000 82.76943  ? 15  ARG B CZ  1 
ATOM   2186 N NH1 . ARG B 1 7   ? -5.12870  9.24250   11.33432 1.000 85.07586  ? 15  ARG B NH1 1 
ATOM   2187 N NH2 . ARG B 1 7   ? -5.18418  7.70516   9.63776  1.000 83.89167  ? 15  ARG B NH2 1 
ATOM   2188 N N   . GLU B 1 8   ? -8.51729  3.70305   17.31801 1.000 56.35325  ? 16  GLU B N   1 
ATOM   2189 C CA  . GLU B 1 8   ? -9.41338  3.81553   18.46611 1.000 47.67970  ? 16  GLU B CA  1 
ATOM   2190 C C   . GLU B 1 8   ? -8.74418  3.36154   19.76138 1.000 42.31057  ? 16  GLU B C   1 
ATOM   2191 O O   . GLU B 1 8   ? -8.31873  2.20583   19.85152 1.000 46.86189  ? 16  GLU B O   1 
ATOM   2192 C CB  . GLU B 1 8   ? -10.67122 2.98593   18.17100 1.000 46.07696  ? 16  GLU B CB  1 
ATOM   2193 C CG  . GLU B 1 8   ? -11.85644 3.29471   19.05384 1.000 44.21153  ? 16  GLU B CG  1 
ATOM   2194 C CD  . GLU B 1 8   ? -13.06002 2.34471   18.84421 1.000 50.58813  ? 16  GLU B CD  1 
ATOM   2195 O OE1 . GLU B 1 8   ? -13.08496 1.56400   17.85726 1.000 52.80016  ? 16  GLU B OE1 1 
ATOM   2196 O OE2 . GLU B 1 8   ? -13.96672 2.34526   19.71254 1.000 49.09262  ? 16  GLU B OE2 1 
ATOM   2197 N N   . PRO B 1 9   ? -8.66217  4.21122   20.80061 1.000 42.01865  ? 17  PRO B N   1 
ATOM   2198 C CA  . PRO B 1 9   ? -8.07296  3.77694   22.08772 1.000 42.19821  ? 17  PRO B CA  1 
ATOM   2199 C C   . PRO B 1 9   ? -9.04452  2.92232   22.88973 1.000 41.65788  ? 17  PRO B C   1 
ATOM   2200 O O   . PRO B 1 9   ? -9.61334  3.36372   23.90827 1.000 38.10425  ? 17  PRO B O   1 
ATOM   2201 C CB  . PRO B 1 9   ? -7.76649  5.11059   22.77570 1.000 40.48518  ? 17  PRO B CB  1 
ATOM   2202 C CG  . PRO B 1 9   ? -8.83630  6.03110   22.28036 1.000 44.04484  ? 17  PRO B CG  1 
ATOM   2203 C CD  . PRO B 1 9   ? -9.16030  5.59798   20.86363 1.000 47.55476  ? 17  PRO B CD  1 
ATOM   2204 N N   . ILE B 1 10  ? -9.21530  1.67183   22.43997 1.000 33.90517  ? 18  ILE B N   1 
ATOM   2205 C CA  . ILE B 1 10  ? -10.25936 0.81811   22.99196 1.000 37.12214  ? 18  ILE B CA  1 
ATOM   2206 C C   . ILE B 1 10  ? -10.02490 0.46223   24.44061 1.000 36.93050  ? 18  ILE B C   1 
ATOM   2207 O O   . ILE B 1 10  ? -10.91861 -0.09662  25.07908 1.000 39.93171  ? 18  ILE B O   1 
ATOM   2208 C CB  . ILE B 1 10  ? -10.44133 -0.47311  22.17982 1.000 33.66277  ? 18  ILE B CB  1 
ATOM   2209 C CG1 . ILE B 1 10  ? -9.14391  -1.28306  22.15262 1.000 40.34740  ? 18  ILE B CG1 1 
ATOM   2210 C CG2 . ILE B 1 10  ? -10.84258 -0.12779  20.76150 1.000 36.08182  ? 18  ILE B CG2 1 
ATOM   2211 C CD1 . ILE B 1 10  ? -9.32476  -2.69480  21.60801 1.000 35.10489  ? 18  ILE B CD1 1 
ATOM   2212 N N   . HIS B 1 11  ? -8.85813  0.76903   24.97659 1.000 33.95924  ? 19  HIS B N   1 
ATOM   2213 C CA  . HIS B 1 11  ? -8.59369  0.58353   26.39566 1.000 35.95115  ? 19  HIS B CA  1 
ATOM   2214 C C   . HIS B 1 11  ? -8.96972  1.80563   27.21001 1.000 31.61420  ? 19  HIS B C   1 
ATOM   2215 O O   . HIS B 1 11  ? -8.86019  1.77522   28.43759 1.000 32.64323  ? 19  HIS B O   1 
ATOM   2216 C CB  . HIS B 1 11  ? -7.09903  0.26683   26.62634 1.000 36.74473  ? 19  HIS B CB  1 
ATOM   2217 C CG  . HIS B 1 11  ? -6.17831  1.30984   26.06874 1.000 34.92813  ? 19  HIS B CG  1 
ATOM   2218 N ND1 . HIS B 1 11  ? -5.06054  1.76408   26.73993 1.000 42.11513  ? 19  HIS B ND1 1 
ATOM   2219 C CD2 . HIS B 1 11  ? -6.20829  1.98354   24.89469 1.000 38.85093  ? 19  HIS B CD2 1 
ATOM   2220 C CE1 . HIS B 1 11  ? -4.44416  2.66962   26.00155 1.000 37.47367  ? 19  HIS B CE1 1 
ATOM   2221 N NE2 . HIS B 1 11  ? -5.11902  2.82029   24.87616 1.000 40.44947  ? 19  HIS B NE2 1 
ATOM   2222 N N   . LEU B 1 12  ? -9.38973  2.88080   26.56317 1.000 34.80821  ? 20  LEU B N   1 
ATOM   2223 C CA  . LEU B 1 12  ? -9.65294  4.13609   27.25338 1.000 41.14915  ? 20  LEU B CA  1 
ATOM   2224 C C   . LEU B 1 12  ? -11.06669 4.63121   26.97944 1.000 38.07306  ? 20  LEU B C   1 
ATOM   2225 O O   . LEU B 1 12  ? -11.31413 5.82611   27.05163 1.000 41.92152  ? 20  LEU B O   1 
ATOM   2226 C CB  . LEU B 1 12  ? -8.63255  5.21385   26.85855 1.000 41.34521  ? 20  LEU B CB  1 
ATOM   2227 C CG  . LEU B 1 12  ? -7.12952  4.94402   27.06189 1.000 39.93378  ? 20  LEU B CG  1 
ATOM   2228 C CD1 . LEU B 1 12  ? -6.27776  6.12987   26.56986 1.000 40.78473  ? 20  LEU B CD1 1 
ATOM   2229 C CD2 . LEU B 1 12  ? -6.77119  4.57415   28.50321 1.000 36.00250  ? 20  LEU B CD2 1 
ATOM   2230 N N   . LEU B 1 13  ? -12.01121 3.73483   26.65717 1.000 37.69356  ? 21  LEU B N   1 
ATOM   2231 C CA  . LEU B 1 13  ? -13.34812 4.20166   26.27377 1.000 33.55862  ? 21  LEU B CA  1 
ATOM   2232 C C   . LEU B 1 13  ? -14.15662 4.69906   27.46118 1.000 37.79483  ? 21  LEU B C   1 
ATOM   2233 O O   . LEU B 1 13  ? -15.11531 5.45628   27.26767 1.000 43.12480  ? 21  LEU B O   1 
ATOM   2234 C CB  . LEU B 1 13  ? -14.12691 3.10206   25.53819 1.000 34.86989  ? 21  LEU B CB  1 
ATOM   2235 C CG  . LEU B 1 13  ? -13.48542 2.60324   24.23768 1.000 36.50779  ? 21  LEU B CG  1 
ATOM   2236 C CD1 . LEU B 1 13  ? -14.32024 1.57497   23.58491 1.000 38.90763  ? 21  LEU B CD1 1 
ATOM   2237 C CD2 . LEU B 1 13  ? -13.32831 3.74703   23.28786 1.000 39.94684  ? 21  LEU B CD2 1 
ATOM   2238 N N   . GLY B 1 14  ? -13.75949 4.34686   28.67799 1.000 36.77810  ? 22  GLY B N   1 
ATOM   2239 C CA  . GLY B 1 14  ? -14.40776 4.85952   29.86494 1.000 37.21332  ? 22  GLY B CA  1 
ATOM   2240 C C   . GLY B 1 14  ? -15.74153 4.23428   30.19828 1.000 40.94737  ? 22  GLY B C   1 
ATOM   2241 O O   . GLY B 1 14  ? -16.53122 4.85786   30.90521 1.000 43.16694  ? 22  GLY B O   1 
ATOM   2242 N N   . GLY B 1 15  ? -15.99913 2.99971   29.74902 1.000 40.33877  ? 23  GLY B N   1 
ATOM   2243 C CA  . GLY B 1 15  ? -17.25271 2.33035   30.03535 1.000 37.93073  ? 23  GLY B CA  1 
ATOM   2244 C C   . GLY B 1 15  ? -17.05153 0.85563   30.33690 1.000 38.82817  ? 23  GLY B C   1 
ATOM   2245 O O   . GLY B 1 15  ? -16.00311 0.26720   30.04181 1.000 39.48720  ? 23  GLY B O   1 
ATOM   2246 N N   . ILE B 1 16  ? -18.08449 0.25815   30.93158 1.000 35.06537  ? 24  ILE B N   1 
ATOM   2247 C CA  . ILE B 1 16  ? -18.15355 -1.18384  31.10905 1.000 34.84851  ? 24  ILE B CA  1 
ATOM   2248 C C   . ILE B 1 16  ? -19.46170 -1.69400  30.51063 1.000 36.13114  ? 24  ILE B C   1 
ATOM   2249 O O   . ILE B 1 16  ? -20.39978 -0.94370  30.23149 1.000 33.17643  ? 24  ILE B O   1 
ATOM   2250 C CB  . ILE B 1 16  ? -18.06464 -1.63468  32.58380 1.000 37.37233  ? 24  ILE B CB  1 
ATOM   2251 C CG1 . ILE B 1 16  ? -19.24582 -1.07264  33.39189 1.000 35.42383  ? 24  ILE B CG1 1 
ATOM   2252 C CG2 . ILE B 1 16  ? -16.70142 -1.25924  33.17657 1.000 34.35914  ? 24  ILE B CG2 1 
ATOM   2253 C CD1 . ILE B 1 16  ? -19.37126 -1.66308  34.78283 1.000 36.79702  ? 24  ILE B CD1 1 
ATOM   2254 N N   . GLN B 1 17  ? -19.51165 -3.00169  30.34110 1.000 38.39791  ? 25  GLN B N   1 
ATOM   2255 C CA  . GLN B 1 17  ? -20.73801 -3.65615  29.94241 1.000 33.61445  ? 25  GLN B CA  1 
ATOM   2256 C C   . GLN B 1 17  ? -21.71695 -3.65723  31.10940 1.000 32.46432  ? 25  GLN B C   1 
ATOM   2257 O O   . GLN B 1 17  ? -21.33675 -3.69247  32.28037 1.000 32.32974  ? 25  GLN B O   1 
ATOM   2258 C CB  . GLN B 1 17  ? -20.42990 -5.07577  29.46329 1.000 36.28874  ? 25  GLN B CB  1 
ATOM   2259 C CG  . GLN B 1 17  ? -19.52159 -5.11836  28.23549 1.000 33.74356  ? 25  GLN B CG  1 
ATOM   2260 C CD  . GLN B 1 17  ? -19.06449 -6.52712  27.89118 1.000 33.21688  ? 25  GLN B CD  1 
ATOM   2261 O OE1 . GLN B 1 17  ? -19.86940 -7.44895  27.86949 1.000 28.25576  ? 25  GLN B OE1 1 
ATOM   2262 N NE2 . GLN B 1 17  ? -17.75705 -6.69707  27.62415 1.000 35.28552  ? 25  GLN B NE2 1 
ATOM   2263 N N   . SER B 1 18  ? -22.99383 -3.58364  30.78243 1.000 32.77079  ? 26  SER B N   1 
ATOM   2264 C CA  . SER B 1 18  ? -23.96085 -3.25109  31.81982 1.000 37.22433  ? 26  SER B CA  1 
ATOM   2265 C C   . SER B 1 18  ? -24.26902 -4.40234  32.76590 1.000 38.63269  ? 26  SER B C   1 
ATOM   2266 O O   . SER B 1 18  ? -24.98275 -4.18695  33.75180 1.000 41.38020  ? 26  SER B O   1 
ATOM   2267 C CB  . SER B 1 18  ? -25.25145 -2.77287  31.18348 1.000 31.72941  ? 26  SER B CB  1 
ATOM   2268 O OG  . SER B 1 18  ? -25.83315 -3.83252  30.46992 1.000 33.71765  ? 26  SER B OG  1 
ATOM   2269 N N   . HIS B 1 19  ? -23.76383 -5.61242  32.51114 1.000 40.03019  ? 27  HIS B N   1 
ATOM   2270 C CA  . HIS B 1 19  ? -24.13360 -6.70065  33.40906 1.000 40.26639  ? 27  HIS B CA  1 
ATOM   2271 C C   . HIS B 1 19  ? -23.32415 -6.71490  34.70048 1.000 41.16809  ? 27  HIS B C   1 
ATOM   2272 O O   . HIS B 1 19  ? -23.71564 -7.41508  35.63499 1.000 41.52932  ? 27  HIS B O   1 
ATOM   2273 C CB  . HIS B 1 19  ? -24.01642 -8.05999  32.70932 1.000 34.29158  ? 27  HIS B CB  1 
ATOM   2274 C CG  . HIS B 1 19  ? -22.62432 -8.44506  32.33340 1.000 36.82192  ? 27  HIS B CG  1 
ATOM   2275 N ND1 . HIS B 1 19  ? -22.01326 -7.99692  31.18465 1.000 34.83392  ? 27  HIS B ND1 1 
ATOM   2276 C CD2 . HIS B 1 19  ? -21.72686 -9.25627  32.94405 1.000 38.84771  ? 27  HIS B CD2 1 
ATOM   2277 C CE1 . HIS B 1 19  ? -20.79702 -8.50767  31.10641 1.000 34.53914  ? 27  HIS B CE1 1 
ATOM   2278 N NE2 . HIS B 1 19  ? -20.59546 -9.26961  32.16471 1.000 37.26703  ? 27  HIS B NE2 1 
ATOM   2279 N N   . GLY B 1 20  ? -22.24421 -5.93467  34.80359 1.000 38.16861  ? 28  GLY B N   1 
ATOM   2280 C CA  . GLY B 1 20  ? -21.40165 -5.94653  35.98241 1.000 39.83318  ? 28  GLY B CA  1 
ATOM   2281 C C   . GLY B 1 20  ? -21.15991 -4.55489  36.53869 1.000 42.26285  ? 28  GLY B C   1 
ATOM   2282 O O   . GLY B 1 20  ? -21.68242 -3.56020  36.03061 1.000 44.11657  ? 28  GLY B O   1 
ATOM   2283 N N   . VAL B 1 21  ? -20.33985 -4.50943  37.59072 1.000 38.54757  ? 29  VAL B N   1 
ATOM   2284 C CA  . VAL B 1 21  ? -20.05847 -3.27878  38.31671 1.000 39.29556  ? 29  VAL B CA  1 
ATOM   2285 C C   . VAL B 1 21  ? -18.55450 -3.19942  38.55511 1.000 41.39661  ? 29  VAL B C   1 
ATOM   2286 O O   . VAL B 1 21  ? -17.90824 -4.20817  38.84492 1.000 40.37785  ? 29  VAL B O   1 
ATOM   2287 C CB  . VAL B 1 21  ? -20.85764 -3.22351  39.64406 1.000 42.51044  ? 29  VAL B CB  1 
ATOM   2288 C CG1 . VAL B 1 21  ? -20.34514 -2.17071  40.58475 1.000 37.50035  ? 29  VAL B CG1 1 
ATOM   2289 C CG2 . VAL B 1 21  ? -22.35631 -2.99070  39.36329 1.000 40.51692  ? 29  VAL B CG2 1 
ATOM   2290 N N   . LEU B 1 22  ? -17.99408 -2.00605  38.40065 1.000 42.64060  ? 30  LEU B N   1 
ATOM   2291 C CA  . LEU B 1 22  ? -16.56756 -1.78104  38.57539 1.000 43.28374  ? 30  LEU B CA  1 
ATOM   2292 C C   . LEU B 1 22  ? -16.34097 -0.65290  39.57623 1.000 44.82865  ? 30  LEU B C   1 
ATOM   2293 O O   . LEU B 1 22  ? -17.01994 0.38049   39.53362 1.000 46.18907  ? 30  LEU B O   1 
ATOM   2294 C CB  . LEU B 1 22  ? -15.90812 -1.46185  37.22735 1.000 35.41101  ? 30  LEU B CB  1 
ATOM   2295 C CG  . LEU B 1 22  ? -14.39820 -1.25312  37.18840 1.000 42.14632  ? 30  LEU B CG  1 
ATOM   2296 C CD1 . LEU B 1 22  ? -13.84734 -1.80839  35.86907 1.000 37.36117  ? 30  LEU B CD1 1 
ATOM   2297 C CD2 . LEU B 1 22  ? -14.02711 0.22173   37.35294 1.000 38.36632  ? 30  LEU B CD2 1 
ATOM   2298 N N   . LEU B 1 23  ? -15.38986 -0.86968  40.47991 1.000 45.12576  ? 31  LEU B N   1 
ATOM   2299 C CA  . LEU B 1 23  ? -14.89627 0.13847   41.40635 1.000 43.65129  ? 31  LEU B CA  1 
ATOM   2300 C C   . LEU B 1 23  ? -13.37990 0.16948   41.29988 1.000 49.20152  ? 31  LEU B C   1 
ATOM   2301 O O   . LEU B 1 23  ? -12.75567 -0.85296  41.01722 1.000 48.61116  ? 31  LEU B O   1 
ATOM   2302 C CB  . LEU B 1 23  ? -15.30717 -0.17587  42.84758 1.000 46.61864  ? 31  LEU B CB  1 
ATOM   2303 C CG  . LEU B 1 23  ? -16.80910 -0.24020  43.17290 1.000 50.13927  ? 31  LEU B CG  1 
ATOM   2304 C CD1 . LEU B 1 23  ? -17.42182 -1.59752  42.86970 1.000 48.66849  ? 31  LEU B CD1 1 
ATOM   2305 C CD2 . LEU B 1 23  ? -16.99997 0.08371   44.62441 1.000 55.99619  ? 31  LEU B CD2 1 
ATOM   2306 N N   . ALA B 1 24  ? -12.78982 1.35209   41.48641 1.000 49.81579  ? 32  ALA B N   1 
ATOM   2307 C CA  . ALA B 1 24  ? -11.33950 1.48224   41.56454 1.000 54.31966  ? 32  ALA B CA  1 
ATOM   2308 C C   . ALA B 1 24  ? -10.98215 2.43498   42.69525 1.000 57.51197  ? 32  ALA B C   1 
ATOM   2309 O O   . ALA B 1 24  ? -11.72898 3.36772   43.00080 1.000 58.35957  ? 32  ALA B O   1 
ATOM   2310 C CB  . ALA B 1 24  ? -10.72063 1.97013   40.24395 1.000 49.68353  ? 32  ALA B CB  1 
ATOM   2311 N N   . PHE B 1 25  ? -9.83891  2.17863   43.32783 1.000 62.61404  ? 33  PHE B N   1 
ATOM   2312 C CA  . PHE B 1 25  ? -9.41118  2.97506   44.47098 1.000 64.89856  ? 33  PHE B CA  1 
ATOM   2313 C C   . PHE B 1 25  ? -7.89596  2.90840   44.63119 1.000 64.08920  ? 33  PHE B C   1 
ATOM   2314 O O   . PHE B 1 25  ? -7.25677  1.91677   44.26328 1.000 62.62281  ? 33  PHE B O   1 
ATOM   2315 C CB  . PHE B 1 25  ? -10.10167 2.51825   45.76016 1.000 65.40196  ? 33  PHE B CB  1 
ATOM   2316 C CG  . PHE B 1 25  ? -10.32440 1.03891   45.84305 1.000 66.92292  ? 33  PHE B CG  1 
ATOM   2317 C CD1 . PHE B 1 25  ? -9.38354  0.21885   46.44968 1.000 71.82576  ? 33  PHE B CD1 1 
ATOM   2318 C CD2 . PHE B 1 25  ? -11.47311 0.46798   45.31633 1.000 65.49309  ? 33  PHE B CD2 1 
ATOM   2319 C CE1 . PHE B 1 25  ? -9.58853  -1.14986  46.53801 1.000 72.95809  ? 33  PHE B CE1 1 
ATOM   2320 C CE2 . PHE B 1 25  ? -11.68840 -0.89079  45.39452 1.000 65.28849  ? 33  PHE B CE2 1 
ATOM   2321 C CZ  . PHE B 1 25  ? -10.74481 -1.70541  46.00398 1.000 71.87256  ? 33  PHE B CZ  1 
ATOM   2322 N N   . ARG B 1 26  ? -7.33340  3.97841   45.18679 1.000 66.61868  ? 34  ARG B N   1 
ATOM   2323 C CA  . ARG B 1 26  ? -5.90510  4.08683   45.45685 1.000 74.65899  ? 34  ARG B CA  1 
ATOM   2324 C C   . ARG B 1 26  ? -5.64123  4.15959   46.95614 1.000 73.44154  ? 34  ARG B C   1 
ATOM   2325 O O   . ARG B 1 26  ? -6.55458  4.19429   47.78500 1.000 71.85864  ? 34  ARG B O   1 
ATOM   2326 C CB  . ARG B 1 26  ? -5.30376  5.32025   44.78628 1.000 73.61605  ? 34  ARG B CB  1 
ATOM   2327 C CG  . ARG B 1 26  ? -5.62937  6.59730   45.53143 1.000 79.09615  ? 34  ARG B CG  1 
ATOM   2328 C CD  . ARG B 1 26  ? -5.22782  7.84155   44.74423 1.000 82.83766  ? 34  ARG B CD  1 
ATOM   2329 N NE  . ARG B 1 26  ? -6.10212  8.96256   45.07835 1.000 86.70848  ? 34  ARG B NE  1 
ATOM   2330 C CZ  . ARG B 1 26  ? -5.73230  10.05336  45.74043 1.000 91.39227  ? 34  ARG B CZ  1 
ATOM   2331 N NH1 . ARG B 1 26  ? -4.47520  10.24434  46.11854 1.000 91.51123  ? 34  ARG B NH1 1 
ATOM   2332 N NH2 . ARG B 1 26  ? -6.65050  10.97156  46.04298 1.000 85.35521  ? 34  ARG B NH2 1 
ATOM   2333 N N   . GLY B 1 27  ? -4.35702  4.18187   47.29317 1.000 76.25272  ? 35  GLY B N   1 
ATOM   2334 C CA  . GLY B 1 27  ? -3.91047  4.54737   48.61528 1.000 77.65216  ? 35  GLY B CA  1 
ATOM   2335 C C   . GLY B 1 27  ? -4.22278  3.51701   49.67864 1.000 80.73194  ? 35  GLY B C   1 
ATOM   2336 O O   . GLY B 1 27  ? -5.00297  2.57828   49.47433 1.000 77.82689  ? 35  GLY B O   1 
ATOM   2337 N N   . PRO B 1 28  ? -3.59207  3.67458   50.84660 1.000 83.31803  ? 36  PRO B N   1 
ATOM   2338 C CA  . PRO B 1 28  ? -3.89608  2.77741   51.97185 1.000 80.83608  ? 36  PRO B CA  1 
ATOM   2339 C C   . PRO B 1 28  ? -5.24085  3.05271   52.60967 1.000 79.19635  ? 36  PRO B C   1 
ATOM   2340 O O   . PRO B 1 28  ? -5.78455  2.15905   53.26885 1.000 79.53637  ? 36  PRO B O   1 
ATOM   2341 C CB  . PRO B 1 28  ? -2.74196  3.03314   52.95312 1.000 81.62006  ? 36  PRO B CB  1 
ATOM   2342 C CG  . PRO B 1 28  ? -1.63333  3.61003   52.09505 1.000 83.19141  ? 36  PRO B CG  1 
ATOM   2343 C CD  . PRO B 1 28  ? -2.34699  4.43426   51.06358 1.000 86.22965  ? 36  PRO B CD  1 
ATOM   2344 N N   . ASP B 1 29  ? -5.79568  4.25633   52.45066 1.000 80.24131  ? 37  ASP B N   1 
ATOM   2345 C CA  . ASP B 1 29  ? -7.16817  4.47563   52.89137 1.000 78.51100  ? 37  ASP B CA  1 
ATOM   2346 C C   . ASP B 1 29  ? -8.18623  3.77525   52.00300 1.000 77.26148  ? 37  ASP B C   1 
ATOM   2347 O O   . ASP B 1 29  ? -9.34544  3.64982   52.41309 1.000 79.96850  ? 37  ASP B O   1 
ATOM   2348 C CB  . ASP B 1 29  ? -7.51041  5.97298   52.95282 1.000 81.72566  ? 37  ASP B CB  1 
ATOM   2349 C CG  . ASP B 1 29  ? -6.63634  6.74848   53.92790 1.000 81.57400  ? 37  ASP B CG  1 
ATOM   2350 O OD1 . ASP B 1 29  ? -6.02300  6.12149   54.81956 1.000 85.01461  ? 37  ASP B OD1 1 
ATOM   2351 O OD2 . ASP B 1 29  ? -6.59542  7.99461   53.81808 1.000 80.72395  ? 37  ASP B OD2 1 
ATOM   2352 N N   . ARG B 1 30  ? -7.78998  3.32791   50.80820 1.000 76.44975  ? 38  ARG B N   1 
ATOM   2353 C CA  . ARG B 1 30  ? -8.69015  2.67036   49.85728 1.000 73.71695  ? 38  ARG B CA  1 
ATOM   2354 C C   . ARG B 1 30  ? -9.83152  3.60267   49.44130 1.000 71.28206  ? 38  ARG B C   1 
ATOM   2355 O O   . ARG B 1 30  ? -11.01401 3.27976   49.55529 1.000 68.45329  ? 38  ARG B O   1 
ATOM   2356 C CB  . ARG B 1 30  ? -9.23643  1.35968   50.43032 1.000 74.77903  ? 38  ARG B CB  1 
ATOM   2357 C CG  . ARG B 1 30  ? -8.19139  0.30749   50.75093 1.000 72.95884  ? 38  ARG B CG  1 
ATOM   2358 C CD  . ARG B 1 30  ? -7.36507  0.00642   49.52125 1.000 76.20284  ? 38  ARG B CD  1 
ATOM   2359 N NE  . ARG B 1 30  ? -7.05287  -1.41146  49.37866 1.000 78.09618  ? 38  ARG B NE  1 
ATOM   2360 C CZ  . ARG B 1 30  ? -6.23802  -1.90024  48.45195 1.000 76.03123  ? 38  ARG B CZ  1 
ATOM   2361 N NH1 . ARG B 1 30  ? -5.62267  -1.10561  47.58839 1.000 73.91932  ? 38  ARG B NH1 1 
ATOM   2362 N NH2 . ARG B 1 30  ? -6.03708  -3.21692  48.38872 1.000 68.38467  ? 38  ARG B NH2 1 
ATOM   2363 N N   . LEU B 1 31  ? -9.44407  4.77537   48.93991 1.000 72.02313  ? 39  LEU B N   1 
ATOM   2364 C CA  . LEU B 1 31  ? -10.38859 5.82980   48.59262 1.000 71.69675  ? 39  LEU B CA  1 
ATOM   2365 C C   . LEU B 1 31  ? -10.90988 5.64407   47.17177 1.000 66.91339  ? 39  LEU B C   1 
ATOM   2366 O O   . LEU B 1 31  ? -10.12843 5.58025   46.21805 1.000 65.65997  ? 39  LEU B O   1 
ATOM   2367 C CB  . LEU B 1 31  ? -9.72849  7.20259   48.74581 1.000 71.51426  ? 39  LEU B CB  1 
ATOM   2368 C CG  . LEU B 1 31  ? -9.15722  7.45684   50.14063 1.000 71.46474  ? 39  LEU B CG  1 
ATOM   2369 C CD1 . LEU B 1 31  ? -8.37974  8.75861   50.19008 1.000 66.81227  ? 39  LEU B CD1 1 
ATOM   2370 C CD2 . LEU B 1 31  ? -10.28779 7.43777   51.16811 1.000 69.71764  ? 39  LEU B CD2 1 
ATOM   2371 N N   . LEU B 1 32  ? -12.23242 5.57781   47.04065 1.000 67.71724  ? 40  LEU B N   1 
ATOM   2372 C CA  . LEU B 1 32  ? -12.87279 5.41934   45.73826 1.000 66.36920  ? 40  LEU B CA  1 
ATOM   2373 C C   . LEU B 1 32  ? -12.48692 6.54151   44.78915 1.000 61.33514  ? 40  LEU B C   1 
ATOM   2374 O O   . LEU B 1 32  ? -12.75336 7.71662   45.06264 1.000 59.24023  ? 40  LEU B O   1 
ATOM   2375 C CB  . LEU B 1 32  ? -14.39240 5.37608   45.89977 1.000 64.08636  ? 40  LEU B CB  1 
ATOM   2376 C CG  . LEU B 1 32  ? -14.96141 3.97054   45.79541 1.000 64.25903  ? 40  LEU B CG  1 
ATOM   2377 C CD1 . LEU B 1 32  ? -14.66039 3.42925   44.41388 1.000 60.68077  ? 40  LEU B CD1 1 
ATOM   2378 C CD2 . LEU B 1 32  ? -14.33651 3.08693   46.84987 1.000 68.42214  ? 40  LEU B CD2 1 
ATOM   2379 N N   . GLU B 1 33  ? -11.90261 6.16999   43.65021 1.000 56.27844  ? 41  GLU B N   1 
ATOM   2380 C CA  . GLU B 1 33  ? -11.59761 7.11979   42.59046 1.000 55.68203  ? 41  GLU B CA  1 
ATOM   2381 C C   . GLU B 1 33  ? -12.37480 6.88337   41.31403 1.000 51.21585  ? 41  GLU B C   1 
ATOM   2382 O O   . GLU B 1 33  ? -12.59422 7.83090   40.55688 1.000 51.22995  ? 41  GLU B O   1 
ATOM   2383 C CB  . GLU B 1 33  ? -10.11028 7.06443   42.23039 1.000 60.91640  ? 41  GLU B CB  1 
ATOM   2384 C CG  . GLU B 1 33  ? -9.53175  8.39955   41.82030 1.000 69.10854  ? 41  GLU B CG  1 
ATOM   2385 C CD  . GLU B 1 33  ? -8.09949  8.51502   42.25566 1.000 72.78086  ? 41  GLU B CD  1 
ATOM   2386 O OE1 . GLU B 1 33  ? -7.79815  7.97637   43.34546 1.000 77.29722  ? 41  GLU B OE1 1 
ATOM   2387 O OE2 . GLU B 1 33  ? -7.28956  9.14208   41.54370 1.000 77.42833  ? 41  GLU B OE2 1 
ATOM   2388 N N   . VAL B 1 34  ? -12.77397 5.64563   41.04646 1.000 51.21851  ? 42  VAL B N   1 
ATOM   2389 C CA  . VAL B 1 34  ? -13.53115 5.29528   39.85239 1.000 53.00480  ? 42  VAL B CA  1 
ATOM   2390 C C   . VAL B 1 34  ? -14.74045 4.48351   40.28287 1.000 49.98752  ? 42  VAL B C   1 
ATOM   2391 O O   . VAL B 1 34  ? -14.64967 3.64626   41.18734 1.000 50.33808  ? 42  VAL B O   1 
ATOM   2392 C CB  . VAL B 1 34  ? -12.68364 4.49850   38.83304 1.000 46.37372  ? 42  VAL B CB  1 
ATOM   2393 C CG1 . VAL B 1 34  ? -13.44211 4.32469   37.52462 1.000 43.23334  ? 42  VAL B CG1 1 
ATOM   2394 C CG2 . VAL B 1 34  ? -11.34542 5.17533   38.59538 1.000 51.56133  ? 42  VAL B CG2 1 
ATOM   2395 N N   . VAL B 1 35  ? -15.87672 4.73768   39.64358 1.000 47.23473  ? 43  VAL B N   1 
ATOM   2396 C CA  . VAL B 1 35  ? -17.07417 3.95217   39.92381 1.000 47.11701  ? 43  VAL B CA  1 
ATOM   2397 C C   . VAL B 1 35  ? -17.98824 3.98730   38.70937 1.000 41.51292  ? 43  VAL B C   1 
ATOM   2398 O O   . VAL B 1 35  ? -18.16667 5.03059   38.07856 1.000 43.05515  ? 43  VAL B O   1 
ATOM   2399 C CB  . VAL B 1 35  ? -17.78205 4.44461   41.20270 1.000 51.17693  ? 43  VAL B CB  1 
ATOM   2400 C CG1 . VAL B 1 35  ? -18.26652 5.87818   41.03099 1.000 50.44432  ? 43  VAL B CG1 1 
ATOM   2401 C CG2 . VAL B 1 35  ? -18.95016 3.51781   41.55102 1.000 47.11121  ? 43  VAL B CG2 1 
ATOM   2402 N N   . SER B 1 36  ? -18.49620 2.82952   38.31995 1.000 39.07246  ? 44  SER B N   1 
ATOM   2403 C CA  . SER B 1 36  ? -19.41789 2.77214   37.20576 1.000 37.97590  ? 44  SER B CA  1 
ATOM   2404 C C   . SER B 1 36  ? -20.75569 3.37838   37.63015 1.000 42.41348  ? 44  SER B C   1 
ATOM   2405 O O   . SER B 1 36  ? -21.15607 3.30401   38.79345 1.000 41.47131  ? 44  SER B O   1 
ATOM   2406 C CB  . SER B 1 36  ? -19.56941 1.32266   36.71975 1.000 39.27629  ? 44  SER B CB  1 
ATOM   2407 O OG  . SER B 1 36  ? -19.92306 0.42246   37.76864 1.000 36.92357  ? 44  SER B OG  1 
ATOM   2408 N N   . ALA B 1 37  ? -21.41476 4.04329   36.68319 1.000 39.90236  ? 45  ALA B N   1 
ATOM   2409 C CA  . ALA B 1 37  ? -22.61450 4.80999   36.99111 1.000 40.29017  ? 45  ALA B CA  1 
ATOM   2410 C C   . ALA B 1 37  ? -23.79037 3.92946   37.39744 1.000 43.61126  ? 45  ALA B C   1 
ATOM   2411 O O   . ALA B 1 37  ? -24.77808 4.44879   37.92361 1.000 44.62184  ? 45  ALA B O   1 
ATOM   2412 C CB  . ALA B 1 37  ? -22.98985 5.66422   35.78645 1.000 32.02013  ? 45  ALA B CB  1 
ATOM   2413 N N   . ASN B 1 38  ? -23.72342 2.62123   37.14344 1.000 42.32890  ? 46  ASN B N   1 
ATOM   2414 C CA  . ASN B 1 38  ? -24.80393 1.70337   37.47841 1.000 39.07226  ? 46  ASN B CA  1 
ATOM   2415 C C   . ASN B 1 38  ? -24.64900 1.12647   38.87610 1.000 40.95817  ? 46  ASN B C   1 
ATOM   2416 O O   . ASN B 1 38  ? -25.37307 0.19710   39.23815 1.000 40.77644  ? 46  ASN B O   1 
ATOM   2417 C CB  . ASN B 1 38  ? -24.86573 0.55624   36.44742 1.000 37.94328  ? 46  ASN B CB  1 
ATOM   2418 C CG  . ASN B 1 38  ? -23.62678 -0.35737  36.50373 1.000 38.88209  ? 46  ASN B CG  1 
ATOM   2419 O OD1 . ASN B 1 38  ? -22.63221 -0.03278  37.15513 1.000 40.87431  ? 46  ASN B OD1 1 
ATOM   2420 N ND2 . ASN B 1 38  ? -23.67354 -1.47772  35.78791 1.000 38.24498  ? 46  ASN B ND2 1 
ATOM   2421 N N   . ALA B 1 39  ? -23.69291 1.62704   39.65616 1.000 42.97945  ? 47  ALA B N   1 
ATOM   2422 C CA  . ALA B 1 39  ? -23.31314 0.92978   40.87984 1.000 42.26278  ? 47  ALA B CA  1 
ATOM   2423 C C   . ALA B 1 39  ? -24.37600 0.98721   41.98097 1.000 46.65198  ? 47  ALA B C   1 
ATOM   2424 O O   . ALA B 1 39  ? -24.30463 0.18225   42.91935 1.000 46.63030  ? 47  ALA B O   1 
ATOM   2425 C CB  . ALA B 1 39  ? -21.98549 1.48136   41.39475 1.000 41.21836  ? 47  ALA B CB  1 
ATOM   2426 N N   . GLN B 1 40  ? -25.36056 1.89827   41.90867 1.000 45.34452  ? 48  GLN B N   1 
ATOM   2427 C CA  . GLN B 1 40  ? -26.25635 2.03193   43.05420 1.000 47.47739  ? 48  GLN B CA  1 
ATOM   2428 C C   . GLN B 1 40  ? -27.11885 0.78591   43.23429 1.000 49.54359  ? 48  GLN B C   1 
ATOM   2429 O O   . GLN B 1 40  ? -27.34921 0.34757   44.36999 1.000 48.51443  ? 48  GLN B O   1 
ATOM   2430 C CB  . GLN B 1 40  ? -27.13286 3.28524   42.94456 1.000 44.37566  ? 48  GLN B CB  1 
ATOM   2431 C CG  . GLN B 1 40  ? -27.92659 3.50899   44.23459 1.000 48.74010  ? 48  GLN B CG  1 
ATOM   2432 C CD  . GLN B 1 40  ? -28.69698 4.83165   44.31771 1.000 50.67507  ? 48  GLN B CD  1 
ATOM   2433 O OE1 . GLN B 1 40  ? -28.62400 5.68138   43.43285 1.000 51.49551  ? 48  GLN B OE1 1 
ATOM   2434 N NE2 . GLN B 1 40  ? -29.44770 4.99288   45.39695 1.000 48.28271  ? 48  GLN B NE2 1 
ATOM   2435 N N   . ALA B 1 41  ? -27.56747 0.17227   42.12948 1.000 51.42483  ? 49  ALA B N   1 
ATOM   2436 C CA  . ALA B 1 41  ? -28.43038 -1.00434  42.23742 1.000 52.36708  ? 49  ALA B CA  1 
ATOM   2437 C C   . ALA B 1 41  ? -27.75981 -2.13662  42.99982 1.000 49.54493  ? 49  ALA B C   1 
ATOM   2438 O O   . ALA B 1 41  ? -28.45194 -3.02056  43.51506 1.000 52.87089  ? 49  ALA B O   1 
ATOM   2439 C CB  . ALA B 1 41  ? -28.86686 -1.49931  40.85315 1.000 47.58352  ? 49  ALA B CB  1 
ATOM   2440 N N   . LEU B 1 42  ? -26.43398 -2.13492  43.08718 1.000 49.79042  ? 50  LEU B N   1 
ATOM   2441 C CA  . LEU B 1 42  ? -25.72501 -3.17909  43.80656 1.000 48.17574  ? 50  LEU B CA  1 
ATOM   2442 C C   . LEU B 1 42  ? -25.17815 -2.73203  45.15159 1.000 50.83508  ? 50  LEU B C   1 
ATOM   2443 O O   . LEU B 1 42  ? -25.14196 -3.53893  46.08205 1.000 57.20710  ? 50  LEU B O   1 
ATOM   2444 C CB  . LEU B 1 42  ? -24.57646 -3.72415  42.94440 1.000 51.87603  ? 50  LEU B CB  1 
ATOM   2445 C CG  . LEU B 1 42  ? -24.11738 -5.15492  43.23329 1.000 50.75736  ? 50  LEU B CG  1 
ATOM   2446 C CD1 . LEU B 1 42  ? -25.30056 -6.07799  43.38753 1.000 48.70166  ? 50  LEU B CD1 1 
ATOM   2447 C CD2 . LEU B 1 42  ? -23.23381 -5.64278  42.09600 1.000 49.77507  ? 50  LEU B CD2 1 
ATOM   2448 N N   . LEU B 1 43  ? -24.78841 -1.46682  45.29323 1.000 49.66037  ? 51  LEU B N   1 
ATOM   2449 C CA  . LEU B 1 43  ? -24.12500 -0.98869  46.49922 1.000 52.28750  ? 51  LEU B CA  1 
ATOM   2450 C C   . LEU B 1 43  ? -25.00324 -0.11182  47.38265 1.000 54.27851  ? 51  LEU B C   1 
ATOM   2451 O O   . LEU B 1 43  ? -24.59419 0.21037   48.50393 1.000 53.37319  ? 51  LEU B O   1 
ATOM   2452 C CB  . LEU B 1 43  ? -22.84739 -0.21065  46.13722 1.000 54.25552  ? 51  LEU B CB  1 
ATOM   2453 C CG  . LEU B 1 43  ? -21.77408 -0.89931  45.28232 1.000 53.42025  ? 51  LEU B CG  1 
ATOM   2454 C CD1 . LEU B 1 43  ? -20.57182 0.01803   45.12924 1.000 53.77603  ? 51  LEU B CD1 1 
ATOM   2455 C CD2 . LEU B 1 43  ? -21.36304 -2.24353  45.87635 1.000 54.74019  ? 51  LEU B CD2 1 
ATOM   2456 N N   . GLY B 1 44  ? -26.17753 0.29879   46.90899 1.000 53.45017  ? 52  GLY B N   1 
ATOM   2457 C CA  . GLY B 1 44  ? -27.15417 0.95385   47.75467 1.000 51.73794  ? 52  GLY B CA  1 
ATOM   2458 C C   . GLY B 1 44  ? -26.94988 2.43001   48.00748 1.000 56.03230  ? 52  GLY B C   1 
ATOM   2459 O O   . GLY B 1 44  ? -27.71360 3.00497   48.79465 1.000 55.51528  ? 52  GLY B O   1 
ATOM   2460 N N   . ARG B 1 45  ? -25.96545 3.06379   47.37458 1.000 56.15790  ? 53  ARG B N   1 
ATOM   2461 C CA  . ARG B 1 45  ? -25.73803 4.49963   47.44023 1.000 54.44231  ? 53  ARG B CA  1 
ATOM   2462 C C   . ARG B 1 45  ? -25.47755 5.02799   46.03712 1.000 54.79385  ? 53  ARG B C   1 
ATOM   2463 O O   . ARG B 1 45  ? -25.05423 4.27423   45.15435 1.000 55.88976  ? 53  ARG B O   1 
ATOM   2464 C CB  . ARG B 1 45  ? -24.53629 4.85178   48.33955 1.000 62.43367  ? 53  ARG B CB  1 
ATOM   2465 C CG  . ARG B 1 45  ? -24.59517 4.42511   49.80204 1.000 64.77974  ? 53  ARG B CG  1 
ATOM   2466 C CD  . ARG B 1 45  ? -23.30530 4.88322   50.53308 1.000 75.10737  ? 53  ARG B CD  1 
ATOM   2467 N NE  . ARG B 1 45  ? -23.49399 5.15307   51.95840 1.000 84.81966  ? 53  ARG B NE  1 
ATOM   2468 C CZ  . ARG B 1 45  ? -23.36119 6.34674   52.53056 1.000 85.36968  ? 53  ARG B CZ  1 
ATOM   2469 N NH1 . ARG B 1 45  ? -23.01830 7.41833   51.82956 1.000 76.58259  ? 53  ARG B NH1 1 
ATOM   2470 N NH2 . ARG B 1 45  ? -23.58514 6.47068   53.83955 1.000 80.34251  ? 53  ARG B NH2 1 
ATOM   2471 N N   . PRO B 1 46  ? -25.67390 6.32986   45.80427 1.000 53.57893  ? 54  PRO B N   1 
ATOM   2472 C CA  . PRO B 1 46  ? -25.38001 6.88041   44.48405 1.000 53.31733  ? 54  PRO B CA  1 
ATOM   2473 C C   . PRO B 1 46  ? -23.87741 6.92575   44.24525 1.000 60.43025  ? 54  PRO B C   1 
ATOM   2474 O O   . PRO B 1 46  ? -23.09888 7.16209   45.18214 1.000 62.32961  ? 54  PRO B O   1 
ATOM   2475 C CB  . PRO B 1 46  ? -25.97069 8.30087   44.54935 1.000 53.11614  ? 54  PRO B CB  1 
ATOM   2476 C CG  . PRO B 1 46  ? -26.79106 8.34535   45.78359 1.000 55.58220  ? 54  PRO B CG  1 
ATOM   2477 C CD  . PRO B 1 46  ? -26.17834 7.36642   46.71774 1.000 53.55512  ? 54  PRO B CD  1 
ATOM   2478 N N   . PRO B 1 47  ? -23.43084 6.71699   43.00118 1.000 59.76238  ? 55  PRO B N   1 
ATOM   2479 C CA  . PRO B 1 47  ? -21.97630 6.66477   42.75830 1.000 57.66037  ? 55  PRO B CA  1 
ATOM   2480 C C   . PRO B 1 47  ? -21.27504 7.95260   43.13931 1.000 62.49720  ? 55  PRO B C   1 
ATOM   2481 O O   . PRO B 1 47  ? -20.21050 7.91737   43.77401 1.000 62.90207  ? 55  PRO B O   1 
ATOM   2482 C CB  . PRO B 1 47  ? -21.88405 6.38719   41.25168 1.000 53.99529  ? 55  PRO B CB  1 
ATOM   2483 C CG  . PRO B 1 47  ? -23.20817 5.74908   40.90638 1.000 55.64079  ? 55  PRO B CG  1 
ATOM   2484 C CD  . PRO B 1 47  ? -24.20741 6.43434   41.78360 1.000 57.51641  ? 55  PRO B CD  1 
ATOM   2485 N N   . GLU B 1 48  ? -21.87005 9.09813   42.78658 1.000 63.85736  ? 56  GLU B N   1 
ATOM   2486 C CA  . GLU B 1 48  ? -21.27622 10.38883  43.12054 1.000 66.59737  ? 56  GLU B CA  1 
ATOM   2487 C C   . GLU B 1 48  ? -21.10674 10.55385  44.62059 1.000 64.22805  ? 56  GLU B C   1 
ATOM   2488 O O   . GLU B 1 48  ? -20.25840 11.33498  45.06610 1.000 70.20546  ? 56  GLU B O   1 
ATOM   2489 C CB  . GLU B 1 48  ? -22.13309 11.51755  42.55695 1.000 65.22446  ? 56  GLU B CB  1 
ATOM   2490 C CG  . GLU B 1 48  ? -22.07525 11.66334  41.02139 1.000 68.53411  ? 56  GLU B CG  1 
ATOM   2491 C CD  . GLU B 1 48  ? -20.67331 11.83523  40.40906 1.000 76.22066  ? 56  GLU B CD  1 
ATOM   2492 O OE1 . GLU B 1 48  ? -19.70278 11.11612  40.75371 1.000 77.38120  ? 56  GLU B OE1 1 
ATOM   2493 O OE2 . GLU B 1 48  ? -20.57127 12.69592  39.49907 1.000 81.15205  ? 56  GLU B OE2 1 
ATOM   2494 N N   . THR B 1 49  ? -21.92412 9.85366   45.40374 1.000 59.69644  ? 57  THR B N   1 
ATOM   2495 C CA  . THR B 1 49  ? -21.76394 9.80320   46.84995 1.000 63.64124  ? 57  THR B CA  1 
ATOM   2496 C C   . THR B 1 49  ? -20.62632 8.87583   47.28219 1.000 66.38856  ? 57  THR B C   1 
ATOM   2497 O O   . THR B 1 49  ? -19.85786 9.21542   48.19193 1.000 68.34427  ? 57  THR B O   1 
ATOM   2498 C CB  . THR B 1 49  ? -23.07694 9.35999   47.48501 1.000 59.85434  ? 57  THR B CB  1 
ATOM   2499 O OG1 . THR B 1 49  ? -24.03047 10.41605  47.34375 1.000 61.71353  ? 57  THR B OG1 1 
ATOM   2500 C CG2 . THR B 1 49  ? -22.88295 9.02829   48.95350 1.000 62.35700  ? 57  THR B CG2 1 
ATOM   2501 N N   . LEU B 1 50  ? -20.49119 7.70400   46.65151 1.000 64.34637  ? 58  LEU B N   1 
ATOM   2502 C CA  . LEU B 1 50  ? -19.48142 6.75997   47.11449 1.000 64.13186  ? 58  LEU B CA  1 
ATOM   2503 C C   . LEU B 1 50  ? -18.06194 7.21556   46.81203 1.000 66.17376  ? 58  LEU B C   1 
ATOM   2504 O O   . LEU B 1 50  ? -17.12182 6.74005   47.46938 1.000 64.51510  ? 58  LEU B O   1 
ATOM   2505 C CB  . LEU B 1 50  ? -19.71154 5.37740   46.51007 1.000 65.36454  ? 58  LEU B CB  1 
ATOM   2506 C CG  . LEU B 1 50  ? -21.03320 4.65335   46.76663 1.000 64.65318  ? 58  LEU B CG  1 
ATOM   2507 C CD1 . LEU B 1 50  ? -21.68218 4.27302   45.45617 1.000 59.58000  ? 58  LEU B CD1 1 
ATOM   2508 C CD2 . LEU B 1 50  ? -20.77883 3.40195   47.60342 1.000 67.72520  ? 58  LEU B CD2 1 
ATOM   2509 N N   . LEU B 1 51  ? -17.87846 8.10706   45.83615 1.000 61.78877  ? 59  LEU B N   1 
ATOM   2510 C CA  . LEU B 1 51  ? -16.54221 8.61978   45.55898 1.000 66.23335  ? 59  LEU B CA  1 
ATOM   2511 C C   . LEU B 1 51  ? -15.97827 9.32168   46.78890 1.000 67.25656  ? 59  LEU B C   1 
ATOM   2512 O O   . LEU B 1 51  ? -16.68100 10.06473  47.48368 1.000 67.48571  ? 59  LEU B O   1 
ATOM   2513 C CB  . LEU B 1 51  ? -16.55614 9.56509   44.35544 1.000 62.62914  ? 59  LEU B CB  1 
ATOM   2514 C CG  . LEU B 1 51  ? -16.70375 8.83306   43.01453 1.000 63.96406  ? 59  LEU B CG  1 
ATOM   2515 C CD1 . LEU B 1 51  ? -16.77597 9.82120   41.85079 1.000 60.72290  ? 59  LEU B CD1 1 
ATOM   2516 C CD2 . LEU B 1 51  ? -15.59624 7.77814   42.79898 1.000 55.49163  ? 59  LEU B CD2 1 
ATOM   2517 N N   . GLY B 1 52  ? -14.70104 9.06226   47.06012 1.000 64.25198  ? 60  GLY B N   1 
ATOM   2518 C CA  . GLY B 1 52  ? -14.02263 9.59159   48.21547 1.000 66.97404  ? 60  GLY B CA  1 
ATOM   2519 C C   . GLY B 1 52  ? -14.02204 8.68015   49.42267 1.000 68.11580  ? 60  GLY B C   1 
ATOM   2520 O O   . GLY B 1 52  ? -13.21130 8.88188   50.33086 1.000 75.16272  ? 60  GLY B O   1 
ATOM   2521 N N   . GLN B 1 53  ? -14.87070 7.69204   49.45004 1.000 67.60323  ? 61  GLN B N   1 
ATOM   2522 C CA  . GLN B 1 53  ? -15.05292 6.83891   50.61315 1.000 70.22200  ? 61  GLN B CA  1 
ATOM   2523 C C   . GLN B 1 53  ? -14.05643 5.68241   50.62540 1.000 71.05122  ? 61  GLN B C   1 
ATOM   2524 O O   . GLN B 1 53  ? -13.57815 5.24942   49.57308 1.000 68.23026  ? 61  GLN B O   1 
ATOM   2525 C CB  . GLN B 1 53  ? -16.46714 6.28199   50.63721 1.000 67.72409  ? 61  GLN B CB  1 
ATOM   2526 C CG  . GLN B 1 53  ? -17.49660 7.25008   51.16511 1.000 74.83096  ? 61  GLN B CG  1 
ATOM   2527 C CD  . GLN B 1 53  ? -17.74383 7.06924   52.64793 1.000 78.75474  ? 61  GLN B CD  1 
ATOM   2528 O OE1 . GLN B 1 53  ? -18.40956 6.11804   53.05811 1.000 79.00329  ? 61  GLN B OE1 1 
ATOM   2529 N NE2 . GLN B 1 53  ? -17.20640 7.97875   53.46370 1.000 76.23099  ? 61  GLN B NE2 1 
ATOM   2530 N N   . PRO B 1 54  ? -13.72026 5.17750   51.80860 1.000 75.62475  ? 62  PRO B N   1 
ATOM   2531 C CA  . PRO B 1 54  ? -12.95176 3.93098   51.88097 1.000 72.13569  ? 62  PRO B CA  1 
ATOM   2532 C C   . PRO B 1 54  ? -13.83433 2.74998   51.51375 1.000 73.32647  ? 62  PRO B C   1 
ATOM   2533 O O   . PRO B 1 54  ? -15.05859 2.79188   51.65903 1.000 75.29050  ? 62  PRO B O   1 
ATOM   2534 C CB  . PRO B 1 54  ? -12.50881 3.86374   53.34715 1.000 72.74727  ? 62  PRO B CB  1 
ATOM   2535 C CG  . PRO B 1 54  ? -12.69495 5.26818   53.87550 1.000 75.91082  ? 62  PRO B CG  1 
ATOM   2536 C CD  . PRO B 1 54  ? -13.86089 5.82290   53.12382 1.000 75.31155  ? 62  PRO B CD  1 
ATOM   2537 N N   . VAL B 1 55  ? -13.19859 1.68298   51.02480 1.000 70.98977  ? 63  VAL B N   1 
ATOM   2538 C CA  . VAL B 1 55  ? -13.97557 0.57099   50.48979 1.000 71.46484  ? 63  VAL B CA  1 
ATOM   2539 C C   . VAL B 1 55  ? -14.67064 -0.18828  51.59839 1.000 72.64111  ? 63  VAL B C   1 
ATOM   2540 O O   . VAL B 1 55  ? -15.76446 -0.73433  51.39532 1.000 71.45057  ? 63  VAL B O   1 
ATOM   2541 C CB  . VAL B 1 55  ? -13.07895 -0.37190  49.67244 1.000 73.85836  ? 63  VAL B CB  1 
ATOM   2542 C CG1 . VAL B 1 55  ? -12.70831 0.28014   48.37928 1.000 74.88682  ? 63  VAL B CG1 1 
ATOM   2543 C CG2 . VAL B 1 55  ? -11.86133 -0.81851  50.46612 1.000 74.03651  ? 63  VAL B CG2 1 
ATOM   2544 N N   . GLY B 1 56  ? -14.07167 -0.20615  52.78724 1.000 68.74154  ? 64  GLY B N   1 
ATOM   2545 C CA  . GLY B 1 56  ? -14.65630 -0.92197  53.90836 1.000 74.12103  ? 64  GLY B CA  1 
ATOM   2546 C C   . GLY B 1 56  ? -16.08087 -0.50812  54.19944 1.000 71.74233  ? 64  GLY B C   1 
ATOM   2547 O O   . GLY B 1 56  ? -16.88317 -1.31786  54.67109 1.000 76.25612  ? 64  GLY B O   1 
ATOM   2548 N N   . ARG B 1 57  ? -16.41508 0.75307   53.93523 1.000 69.63873  ? 65  ARG B N   1 
ATOM   2549 C CA  . ARG B 1 57  ? -17.77876 1.24774   54.08010 1.000 79.90446  ? 65  ARG B CA  1 
ATOM   2550 C C   . ARG B 1 57  ? -18.43572 1.51526   52.72278 1.000 78.70665  ? 65  ARG B C   1 
ATOM   2551 O O   . ARG B 1 57  ? -19.31019 2.37383   52.60243 1.000 77.95184  ? 65  ARG B O   1 
ATOM   2552 C CB  . ARG B 1 57  ? -17.79615 2.49425   54.96419 1.000 79.89933  ? 65  ARG B CB  1 
ATOM   2553 C CG  . ARG B 1 57  ? -16.97353 3.66649   54.44001 1.000 78.53363  ? 65  ARG B CG  1 
ATOM   2554 C CD  . ARG B 1 57  ? -16.87082 4.79733   55.47566 1.000 84.06013  ? 65  ARG B CD  1 
ATOM   2555 N NE  . ARG B 1 57  ? -18.17592 5.24454   55.96198 1.000 82.97189  ? 65  ARG B NE  1 
ATOM   2556 C CZ  . ARG B 1 57  ? -18.35373 6.19014   56.87822 1.000 83.60669  ? 65  ARG B CZ  1 
ATOM   2557 N NH1 . ARG B 1 57  ? -17.32899 6.83976   57.41106 1.000 84.08658  ? 65  ARG B NH1 1 
ATOM   2558 N NH2 . ARG B 1 57  ? -19.59103 6.49593   57.26761 1.000 77.89284  ? 65  ARG B NH2 1 
ATOM   2559 N N   . VAL B 1 58  ? -18.02303 0.77461   51.69351 1.000 78.18601  ? 66  VAL B N   1 
ATOM   2560 C CA  . VAL B 1 58  ? -18.56706 0.92409   50.35054 1.000 74.27173  ? 66  VAL B CA  1 
ATOM   2561 C C   . VAL B 1 58  ? -19.05628 -0.42183  49.83667 1.000 71.37220  ? 66  VAL B C   1 
ATOM   2562 O O   . VAL B 1 58  ? -20.17628 -0.53652  49.33105 1.000 67.85485  ? 66  VAL B O   1 
ATOM   2563 C CB  . VAL B 1 58  ? -17.51184 1.51463   49.39182 1.000 77.92389  ? 66  VAL B CB  1 
ATOM   2564 C CG1 . VAL B 1 58  ? -17.81844 1.11382   47.94925 1.000 72.10354  ? 66  VAL B CG1 1 
ATOM   2565 C CG2 . VAL B 1 58  ? -17.43676 3.03267   49.53705 1.000 72.96391  ? 66  VAL B CG2 1 
ATOM   2566 N N   . LEU B 1 59  ? -18.20124 -1.46201  49.95610 1.000 73.09655  ? 67  LEU B N   1 
ATOM   2567 C CA  . LEU B 1 59  ? -18.55130 -2.78839  49.47586 1.000 68.52652  ? 67  LEU B CA  1 
ATOM   2568 C C   . LEU B 1 59  ? -19.53762 -3.47019  50.42096 1.000 68.40058  ? 67  LEU B C   1 
ATOM   2569 O O   . LEU B 1 59  ? -19.52927 -3.21390  51.62723 1.000 68.78344  ? 67  LEU B O   1 
ATOM   2570 C CB  . LEU B 1 59  ? -17.30663 -3.66000  49.34164 1.000 68.19072  ? 67  LEU B CB  1 
ATOM   2571 C CG  . LEU B 1 59  ? -16.42120 -3.51980  48.10189 1.000 69.18292  ? 67  LEU B CG  1 
ATOM   2572 C CD1 . LEU B 1 59  ? -17.26542 -3.45743  46.83714 1.000 67.58407  ? 67  LEU B CD1 1 
ATOM   2573 C CD2 . LEU B 1 59  ? -15.50823 -2.32382  48.20030 1.000 72.82302  ? 67  LEU B CD2 1 
ATOM   2574 N N   . PRO B 1 60  ? -20.39172 -4.35326  49.89888 1.000 67.89081  ? 68  PRO B N   1 
ATOM   2575 C CA  . PRO B 1 60  ? -21.19877 -5.19203  50.78751 1.000 67.71347  ? 68  PRO B CA  1 
ATOM   2576 C C   . PRO B 1 60  ? -20.29740 -6.03703  51.67972 1.000 67.89546  ? 68  PRO B C   1 
ATOM   2577 O O   . PRO B 1 60  ? -19.15478 -6.34806  51.33333 1.000 66.93061  ? 68  PRO B O   1 
ATOM   2578 C CB  . PRO B 1 60  ? -22.02005 -6.05364  49.81964 1.000 67.58008  ? 68  PRO B CB  1 
ATOM   2579 C CG  . PRO B 1 60  ? -21.26333 -6.00349  48.52577 1.000 64.83511  ? 68  PRO B CG  1 
ATOM   2580 C CD  . PRO B 1 60  ? -20.65270 -4.64556  48.47975 1.000 64.92718  ? 68  PRO B CD  1 
ATOM   2581 N N   . ALA B 1 61  ? -20.82099 -6.38341  52.85736 1.000 65.70827  ? 69  ALA B N   1 
ATOM   2582 C CA  . ALA B 1 61  ? -20.01907 -7.09466  53.84299 1.000 65.86837  ? 69  ALA B CA  1 
ATOM   2583 C C   . ALA B 1 61  ? -19.63882 -8.49317  53.37729 1.000 66.26461  ? 69  ALA B C   1 
ATOM   2584 O O   . ALA B 1 61  ? -18.57632 -8.99425  53.75947 1.000 65.42525  ? 69  ALA B O   1 
ATOM   2585 C CB  . ALA B 1 61  ? -20.75673 -7.16134  55.17435 1.000 67.31502  ? 69  ALA B CB  1 
ATOM   2586 N N   . GLU B 1 62  ? -20.48049 -9.14113  52.56162 1.000 65.94800  ? 70  GLU B N   1 
ATOM   2587 C CA  . GLU B 1 62  ? -20.13195 -10.47163 52.07146 1.000 61.17820  ? 70  GLU B CA  1 
ATOM   2588 C C   . GLU B 1 62  ? -18.85264 -10.42537 51.25537 1.000 65.45192  ? 70  GLU B C   1 
ATOM   2589 O O   . GLU B 1 62  ? -18.08088 -11.39339 51.23984 1.000 65.09773  ? 70  GLU B O   1 
ATOM   2590 C CB  . GLU B 1 62  ? -21.24572 -11.06209 51.20136 1.000 60.55064  ? 70  GLU B CB  1 
ATOM   2591 C CG  . GLU B 1 62  ? -22.68198 -11.05591 51.75434 1.000 61.12723  ? 70  GLU B CG  1 
ATOM   2592 C CD  . GLU B 1 62  ? -23.27698 -9.65875  51.94891 1.000 65.14537  ? 70  GLU B CD  1 
ATOM   2593 O OE1 . GLU B 1 62  ? -22.65688 -8.65698  51.52155 1.000 66.38510  ? 70  GLU B OE1 1 
ATOM   2594 O OE2 . GLU B 1 62  ? -24.39593 -9.56931  52.49429 1.000 63.60181  ? 70  GLU B OE2 1 
ATOM   2595 N N   . VAL B 1 63  ? -18.61078 -9.30310  50.58105 1.000 66.46135  ? 71  VAL B N   1 
ATOM   2596 C CA  . VAL B 1 63  ? -17.42042 -9.15509  49.75776 1.000 63.94463  ? 71  VAL B CA  1 
ATOM   2597 C C   . VAL B 1 63  ? -16.19820 -8.92699  50.62884 1.000 65.76756  ? 71  VAL B C   1 
ATOM   2598 O O   . VAL B 1 63  ? -15.16271 -9.58127  50.45572 1.000 62.84323  ? 71  VAL B O   1 
ATOM   2599 C CB  . VAL B 1 63  ? -17.61525 -7.99899  48.76184 1.000 64.19088  ? 71  VAL B CB  1 
ATOM   2600 C CG1 . VAL B 1 63  ? -16.28599 -7.62556  48.12788 1.000 62.54928  ? 71  VAL B CG1 1 
ATOM   2601 C CG2 . VAL B 1 63  ? -18.64697 -8.36707  47.71340 1.000 61.42325  ? 71  VAL B CG2 1 
ATOM   2602 N N   . LEU B 1 64  ? -16.30089 -7.97907  51.56578 1.000 67.10022  ? 72  LEU B N   1 
ATOM   2603 C CA  . LEU B 1 64  ? -15.20621 -7.72063  52.49401 1.000 67.19742  ? 72  LEU B CA  1 
ATOM   2604 C C   . LEU B 1 64  ? -14.85716 -8.95918  53.30363 1.000 66.17687  ? 72  LEU B C   1 
ATOM   2605 O O   . LEU B 1 64  ? -13.70351 -9.12597  53.70666 1.000 66.12228  ? 72  LEU B O   1 
ATOM   2606 C CB  . LEU B 1 64  ? -15.56480 -6.55478  53.41711 1.000 67.68658  ? 72  LEU B CB  1 
ATOM   2607 C CG  . LEU B 1 64  ? -15.74000 -5.19007  52.74928 1.000 69.28678  ? 72  LEU B CG  1 
ATOM   2608 C CD1 . LEU B 1 64  ? -16.76187 -4.36608  53.50671 1.000 66.72107  ? 72  LEU B CD1 1 
ATOM   2609 C CD2 . LEU B 1 64  ? -14.40548 -4.44572  52.66152 1.000 70.00506  ? 72  LEU B CD2 1 
ATOM   2610 N N   . ALA B 1 65  ? -15.84059 -9.81948  53.57291 1.000 63.45555  ? 73  ALA B N   1 
ATOM   2611 C CA  . ALA B 1 65  ? -15.55680 -11.11297 54.18383 1.000 64.29973  ? 73  ALA B CA  1 
ATOM   2612 C C   . ALA B 1 65  ? -14.46080 -11.84695 53.42158 1.000 70.10456  ? 73  ALA B C   1 
ATOM   2613 O O   . ALA B 1 65  ? -13.39023 -12.14262 53.96551 1.000 72.41634  ? 73  ALA B O   1 
ATOM   2614 C CB  . ALA B 1 65  ? -16.82881 -11.95621 54.23978 1.000 67.07284  ? 73  ALA B CB  1 
ATOM   2615 N N   . GLN B 1 66  ? -14.70995 -12.13987 52.14676 1.000 70.78869  ? 74  GLN B N   1 
ATOM   2616 C CA  . GLN B 1 66  ? -13.77056 -12.88609 51.32138 1.000 65.73845  ? 74  GLN B CA  1 
ATOM   2617 C C   . GLN B 1 66  ? -12.61342 -12.03869 50.81574 1.000 65.29466  ? 74  GLN B C   1 
ATOM   2618 O O   . GLN B 1 66  ? -11.96390 -12.43756 49.84583 1.000 68.25318  ? 74  GLN B O   1 
ATOM   2619 C CB  . GLN B 1 66  ? -14.51188 -13.50850 50.13993 1.000 68.03404  ? 74  GLN B CB  1 
ATOM   2620 C CG  . GLN B 1 66  ? -15.62149 -14.44326 50.55922 1.000 67.10025  ? 74  GLN B CG  1 
ATOM   2621 C CD  . GLN B 1 66  ? -15.08270 -15.77261 51.01274 1.000 73.95139  ? 74  GLN B CD  1 
ATOM   2622 O OE1 . GLN B 1 66  ? -14.52273 -16.52979 50.22070 1.000 73.76679  ? 74  GLN B OE1 1 
ATOM   2623 N NE2 . GLN B 1 66  ? -15.22219 -16.05775 52.30177 1.000 79.82481  ? 74  GLN B NE2 1 
ATOM   2624 N N   . TRP B 1 67  ? -12.33004 -10.89753 51.44914 1.000 65.81849  ? 75  TRP B N   1 
ATOM   2625 C CA  . TRP B 1 67  ? -11.34636 -9.96578  50.90333 1.000 65.28442  ? 75  TRP B CA  1 
ATOM   2626 C C   . TRP B 1 67  ? -9.93655  -10.53960 50.92152 1.000 66.79637  ? 75  TRP B C   1 
ATOM   2627 O O   . TRP B 1 67  ? -9.10507  -10.15625 50.08973 1.000 67.00708  ? 75  TRP B O   1 
ATOM   2628 C CB  . TRP B 1 67  ? -11.38024 -8.64861  51.67182 1.000 65.07977  ? 75  TRP B CB  1 
ATOM   2629 C CG  . TRP B 1 67  ? -10.50341 -7.60603  51.06870 1.000 67.30901  ? 75  TRP B CG  1 
ATOM   2630 C CD1 . TRP B 1 67  ? -9.26135  -7.22765  51.49653 1.000 66.40412  ? 75  TRP B CD1 1 
ATOM   2631 C CD2 . TRP B 1 67  ? -10.79300 -6.80356  49.91589 1.000 69.09732  ? 75  TRP B CD2 1 
ATOM   2632 N NE1 . TRP B 1 67  ? -8.76152  -6.23102  50.68579 1.000 66.15526  ? 75  TRP B NE1 1 
ATOM   2633 C CE2 . TRP B 1 67  ? -9.68118  -5.95336  49.70842 1.000 66.06552  ? 75  TRP B CE2 1 
ATOM   2634 C CE3 . TRP B 1 67  ? -11.88717 -6.71494  49.04152 1.000 63.16897  ? 75  TRP B CE3 1 
ATOM   2635 C CZ2 . TRP B 1 67  ? -9.63016  -5.03319  48.66224 1.000 65.28464  ? 75  TRP B CZ2 1 
ATOM   2636 C CZ3 . TRP B 1 67  ? -11.83171 -5.80240  48.00255 1.000 61.27154  ? 75  TRP B CZ3 1 
ATOM   2637 C CH2 . TRP B 1 67  ? -10.71071 -4.97332  47.82244 1.000 63.37536  ? 75  TRP B CH2 1 
ATOM   2638 N N   . GLU B 1 68  ? -9.64012  -11.44324 51.86847 1.000 68.45224  ? 76  GLU B N   1 
ATOM   2639 C CA  . GLU B 1 68  ? -8.29820  -12.02631 51.92145 1.000 69.30113  ? 76  GLU B CA  1 
ATOM   2640 C C   . GLU B 1 68  ? -8.01933  -12.90877 50.70797 1.000 66.30775  ? 76  GLU B C   1 
ATOM   2641 O O   . GLU B 1 68  ? -7.06060  -12.62544 49.96699 1.000 63.91960  ? 76  GLU B O   1 
ATOM   2642 C CB  . GLU B 1 68  ? -8.10364  -12.76523 53.24903 1.000 72.98130  ? 76  GLU B CB  1 
ATOM   2643 C CG  . GLU B 1 68  ? -7.46253  -11.94553 54.34527 1.000 76.34129  ? 76  GLU B CG  1 
ATOM   2644 C CD  . GLU B 1 68  ? -5.94977  -11.89053 54.19723 1.000 85.53652  ? 76  GLU B CD  1 
ATOM   2645 O OE1 . GLU B 1 68  ? -5.41676  -12.52091 53.25121 1.000 79.19381  ? 76  GLU B OE1 1 
ATOM   2646 O OE2 . GLU B 1 68  ? -5.29229  -11.23276 55.03618 1.000 92.28268  ? 76  GLU B OE2 1 
ATOM   2647 N N   . PRO B 1 69  ? -8.80384  -13.96011 50.42149 1.000 68.70203  ? 77  PRO B N   1 
ATOM   2648 C CA  . PRO B 1 69  ? -8.55898  -14.71091 49.17930 1.000 65.27526  ? 77  PRO B CA  1 
ATOM   2649 C C   . PRO B 1 69  ? -8.81716  -13.89881 47.91846 1.000 66.34447  ? 77  PRO B C   1 
ATOM   2650 O O   . PRO B 1 69  ? -8.26183  -14.24333 46.86902 1.000 64.10639  ? 77  PRO B O   1 
ATOM   2651 C CB  . PRO B 1 69  ? -9.51904  -15.90169 49.28698 1.000 62.97399  ? 77  PRO B CB  1 
ATOM   2652 C CG  . PRO B 1 69  ? -10.61626 -15.40502 50.13984 1.000 66.36809  ? 77  PRO B CG  1 
ATOM   2653 C CD  . PRO B 1 69  ? -9.96822  -14.50328 51.14966 1.000 66.85779  ? 77  PRO B CD  1 
ATOM   2654 N N   . LEU B 1 70  ? -9.63181  -12.83508 47.97746 1.000 63.45285  ? 78  LEU B N   1 
ATOM   2655 C CA  . LEU B 1 70  ? -9.80529  -11.99559 46.79470 1.000 61.10334  ? 78  LEU B CA  1 
ATOM   2656 C C   . LEU B 1 70  ? -8.50338  -11.29282 46.43504 1.000 61.63475  ? 78  LEU B C   1 
ATOM   2657 O O   . LEU B 1 70  ? -8.13115  -11.23178 45.25679 1.000 61.64488  ? 78  LEU B O   1 
ATOM   2658 C CB  . LEU B 1 70  ? -10.92382 -10.97378 47.00406 1.000 58.79030  ? 78  LEU B CB  1 
ATOM   2659 C CG  . LEU B 1 70  ? -11.07695 -9.97834  45.84313 1.000 57.40903  ? 78  LEU B CG  1 
ATOM   2660 C CD1 . LEU B 1 70  ? -11.33364 -10.68875 44.52628 1.000 52.55715  ? 78  LEU B CD1 1 
ATOM   2661 C CD2 . LEU B 1 70  ? -12.16880 -8.95721  46.11668 1.000 54.01972  ? 78  LEU B CD2 1 
ATOM   2662 N N   . VAL B 1 71  ? -7.80211  -10.74131 47.42919 1.000 61.99680  ? 79  VAL B N   1 
ATOM   2663 C CA  . VAL B 1 71  ? -6.46348  -10.21696 47.16791 1.000 64.67426  ? 79  VAL B CA  1 
ATOM   2664 C C   . VAL B 1 71  ? -5.49173  -11.36501 46.88379 1.000 64.77462  ? 79  VAL B C   1 
ATOM   2665 O O   . VAL B 1 71  ? -4.61491  -11.25841 46.01515 1.000 62.71785  ? 79  VAL B O   1 
ATOM   2666 C CB  . VAL B 1 71  ? -5.98782  -9.33348  48.33555 1.000 64.26890  ? 79  VAL B CB  1 
ATOM   2667 C CG1 . VAL B 1 71  ? -4.62492  -8.72364  48.01596 1.000 62.59931  ? 79  VAL B CG1 1 
ATOM   2668 C CG2 . VAL B 1 71  ? -6.99533  -8.24798  48.61624 1.000 63.57900  ? 79  VAL B CG2 1 
ATOM   2669 N N   . ALA B 1 72  ? -5.62233  -12.47361 47.61755 1.000 61.20110  ? 80  ALA B N   1 
ATOM   2670 C CA  . ALA B 1 72  ? -4.72113  -13.60758 47.42808 1.000 63.84610  ? 80  ALA B CA  1 
ATOM   2671 C C   . ALA B 1 72  ? -4.87128  -14.21696 46.03786 1.000 64.10997  ? 80  ALA B C   1 
ATOM   2672 O O   . ALA B 1 72  ? -3.90538  -14.28613 45.26920 1.000 64.05357  ? 80  ALA B O   1 
ATOM   2673 C CB  . ALA B 1 72  ? -4.97641  -14.66765 48.50413 1.000 62.27821  ? 80  ALA B CB  1 
ATOM   2674 N N   . ARG B 1 73  ? -6.08759  -14.65146 45.68859 1.000 61.08219  ? 81  ARG B N   1 
ATOM   2675 C CA  . ARG B 1 73  ? -6.30101  -15.41905 44.46879 1.000 58.33957  ? 81  ARG B CA  1 
ATOM   2676 C C   . ARG B 1 73  ? -6.71171  -14.55287 43.27959 1.000 57.46439  ? 81  ARG B C   1 
ATOM   2677 O O   . ARG B 1 73  ? -6.70357  -15.03491 42.14394 1.000 59.80381  ? 81  ARG B O   1 
ATOM   2678 C CB  . ARG B 1 73  ? -7.37086  -16.50358 44.71296 1.000 62.45451  ? 81  ARG B CB  1 
ATOM   2679 C CG  . ARG B 1 73  ? -7.29236  -17.16308 46.11014 1.000 67.12050  ? 81  ARG B CG  1 
ATOM   2680 C CD  . ARG B 1 73  ? -7.32616  -18.69277 46.11948 1.000 68.70306  ? 81  ARG B CD  1 
ATOM   2681 N NE  . ARG B 1 73  ? -8.24164  -19.25330 45.13282 1.000 81.66008  ? 81  ARG B NE  1 
ATOM   2682 C CZ  . ARG B 1 73  ? -8.52031  -20.54626 45.00726 1.000 87.13453  ? 81  ARG B CZ  1 
ATOM   2683 N NH1 . ARG B 1 73  ? -7.96860  -21.45464 45.79909 1.000 88.40798  ? 81  ARG B NH1 1 
ATOM   2684 N NH2 . ARG B 1 73  ? -9.36123  -20.94005 44.05120 1.000 85.41211  ? 81  ARG B NH2 1 
ATOM   2685 N N   . GLY B 1 74  ? -7.07227  -13.29442 43.50290 1.000 59.64310  ? 82  GLY B N   1 
ATOM   2686 C CA  . GLY B 1 74  ? -7.55001  -12.43845 42.43805 1.000 59.04754  ? 82  GLY B CA  1 
ATOM   2687 C C   . GLY B 1 74  ? -9.00358  -12.63165 42.06332 1.000 53.26954  ? 82  GLY B C   1 
ATOM   2688 O O   . GLY B 1 74  ? -9.55030  -11.80325 41.32979 1.000 52.53445  ? 82  GLY B O   1 
ATOM   2689 N N   . SER B 1 75  ? -9.64792  -13.69506 42.53658 1.000 58.33257  ? 83  SER B N   1 
ATOM   2690 C CA  . SER B 1 75  ? -11.06161 -13.91814 42.28592 1.000 56.07436  ? 83  SER B CA  1 
ATOM   2691 C C   . SER B 1 75  ? -11.65512 -14.69468 43.45233 1.000 57.98428  ? 83  SER B C   1 
ATOM   2692 O O   . SER B 1 75  ? -10.96341 -15.48168 44.10449 1.000 60.74080  ? 83  SER B O   1 
ATOM   2693 C CB  . SER B 1 75  ? -11.28870 -14.68867 40.98162 1.000 57.74654  ? 83  SER B CB  1 
ATOM   2694 O OG  . SER B 1 75  ? -11.50376 -16.06638 41.23037 1.000 60.93014  ? 83  SER B OG  1 
ATOM   2695 N N   . VAL B 1 76  ? -12.94726 -14.48211 43.68931 1.000 57.22968  ? 84  VAL B N   1 
ATOM   2696 C CA  . VAL B 1 76  ? -13.69474 -15.20510 44.71752 1.000 59.68791  ? 84  VAL B CA  1 
ATOM   2697 C C   . VAL B 1 76  ? -15.18095 -15.08810 44.38715 1.000 55.07294  ? 84  VAL B C   1 
ATOM   2698 O O   . VAL B 1 76  ? -15.62982 -14.07861 43.84183 1.000 54.27579  ? 84  VAL B O   1 
ATOM   2699 C CB  . VAL B 1 76  ? -13.36692 -14.67427 46.13627 1.000 58.95275  ? 84  VAL B CB  1 
ATOM   2700 C CG1 . VAL B 1 76  ? -13.85644 -13.24648 46.31774 1.000 56.65831  ? 84  VAL B CG1 1 
ATOM   2701 C CG2 . VAL B 1 76  ? -13.94344 -15.59426 47.20613 1.000 61.29888  ? 84  VAL B CG2 1 
ATOM   2702 N N   . ARG B 1 77  ? -15.93211 -16.15017 44.66020 1.000 57.02866  ? 85  ARG B N   1 
ATOM   2703 C CA  . ARG B 1 77  ? -17.38279 -16.09557 44.53813 1.000 56.01367  ? 85  ARG B CA  1 
ATOM   2704 C C   . ARG B 1 77  ? -17.97560 -15.64102 45.86501 1.000 56.95250  ? 85  ARG B C   1 
ATOM   2705 O O   . ARG B 1 77  ? -17.47565 -15.98527 46.94105 1.000 53.36967  ? 85  ARG B O   1 
ATOM   2706 C CB  . ARG B 1 77  ? -17.98044 -17.45061 44.13902 1.000 55.13313  ? 85  ARG B CB  1 
ATOM   2707 C CG  . ARG B 1 77  ? -17.30836 -18.16338 42.96421 1.000 61.72158  ? 85  ARG B CG  1 
ATOM   2708 C CD  . ARG B 1 77  ? -17.13386 -17.28590 41.73356 1.000 58.58793  ? 85  ARG B CD  1 
ATOM   2709 N NE  . ARG B 1 77  ? -15.98004 -17.72190 40.95280 1.000 62.26566  ? 85  ARG B NE  1 
ATOM   2710 C CZ  . ARG B 1 77  ? -14.77629 -17.15196 40.99408 1.000 66.93413  ? 85  ARG B CZ  1 
ATOM   2711 N NH1 . ARG B 1 77  ? -14.53301 -16.09323 41.74829 1.000 66.16559  ? 85  ARG B NH1 1 
ATOM   2712 N NH2 . ARG B 1 77  ? -13.79565 -17.63705 40.23692 1.000 62.66865  ? 85  ARG B NH2 1 
ATOM   2713 N N   . VAL B 1 78  ? -19.01747 -14.82596 45.77884 1.000 52.61028  ? 86  VAL B N   1 
ATOM   2714 C CA  . VAL B 1 78  ? -19.72207 -14.32098 46.94666 1.000 53.75083  ? 86  VAL B CA  1 
ATOM   2715 C C   . VAL B 1 78  ? -21.21172 -14.38338 46.66594 1.000 52.99528  ? 86  VAL B C   1 
ATOM   2716 O O   . VAL B 1 78  ? -21.64700 -14.33198 45.51404 1.000 53.33224  ? 86  VAL B O   1 
ATOM   2717 C CB  . VAL B 1 78  ? -19.27514 -12.89280 47.34105 1.000 55.76658  ? 86  VAL B CB  1 
ATOM   2718 C CG1 . VAL B 1 78  ? -17.78590 -12.86361 47.67288 1.000 56.41731  ? 86  VAL B CG1 1 
ATOM   2719 C CG2 . VAL B 1 78  ? -19.57695 -11.91742 46.21810 1.000 50.91474  ? 86  VAL B CG2 1 
ATOM   2720 N N   . VAL B 1 79  ? -21.99695 -14.53053 47.72642 1.000 57.34911  ? 87  VAL B N   1 
ATOM   2721 C CA  . VAL B 1 79  ? -23.44906 -14.58554 47.61336 1.000 52.86672  ? 87  VAL B CA  1 
ATOM   2722 C C   . VAL B 1 79  ? -24.00367 -13.32727 48.26549 1.000 53.96582  ? 87  VAL B C   1 
ATOM   2723 O O   . VAL B 1 79  ? -24.00167 -13.19744 49.49739 1.000 56.94113  ? 87  VAL B O   1 
ATOM   2724 C CB  . VAL B 1 79  ? -24.02538 -15.85746 48.24518 1.000 52.95123  ? 87  VAL B CB  1 
ATOM   2725 C CG1 . VAL B 1 79  ? -25.51204 -15.91965 47.99992 1.000 53.50023  ? 87  VAL B CG1 1 
ATOM   2726 C CG2 . VAL B 1 79  ? -23.34866 -17.07449 47.64757 1.000 53.41127  ? 87  VAL B CG2 1 
ATOM   2727 N N   . LEU B 1 80  ? -24.46895 -12.39621 47.43419 1.000 52.93743  ? 88  LEU B N   1 
ATOM   2728 C CA  . LEU B 1 80  ? -25.09313 -11.16035 47.87371 1.000 52.30721  ? 88  LEU B CA  1 
ATOM   2729 C C   . LEU B 1 80  ? -26.59754 -11.35196 47.96775 1.000 52.50112  ? 88  LEU B C   1 
ATOM   2730 O O   . LEU B 1 80  ? -27.14980 -12.31294 47.41536 1.000 51.60673  ? 88  LEU B O   1 
ATOM   2731 C CB  . LEU B 1 80  ? -24.77834 -10.03699 46.89240 1.000 48.76001  ? 88  LEU B CB  1 
ATOM   2732 C CG  . LEU B 1 80  ? -23.30990 -9.87081  46.54903 1.000 51.49625  ? 88  LEU B CG  1 
ATOM   2733 C CD1 . LEU B 1 80  ? -23.15774 -8.81691  45.46985 1.000 50.46905  ? 88  LEU B CD1 1 
ATOM   2734 C CD2 . LEU B 1 80  ? -22.53428 -9.49716  47.80202 1.000 56.40887  ? 88  LEU B CD2 1 
ATOM   2735 N N   . PRO B 1 81  ? -27.30002 -10.46981 48.67459 1.000 54.63843  ? 89  PRO B N   1 
ATOM   2736 C CA  . PRO B 1 81  ? -28.76817 -10.50806 48.58750 1.000 52.07036  ? 89  PRO B CA  1 
ATOM   2737 C C   . PRO B 1 81  ? -29.26895 -10.52437 47.14655 1.000 51.71061  ? 89  PRO B C   1 
ATOM   2738 O O   . PRO B 1 81  ? -30.27190 -11.19207 46.86283 1.000 52.12698  ? 89  PRO B O   1 
ATOM   2739 C CB  . PRO B 1 81  ? -29.20713 -9.24665  49.35484 1.000 53.32384  ? 89  PRO B CB  1 
ATOM   2740 C CG  . PRO B 1 81  ? -27.93361 -8.46351  49.65681 1.000 54.75463  ? 89  PRO B CG  1 
ATOM   2741 C CD  . PRO B 1 81  ? -26.82084 -9.46875  49.64463 1.000 53.97974  ? 89  PRO B CD  1 
ATOM   2742 N N   . ALA B 1 82  ? -28.57640 -9.85021  46.21609 1.000 49.74913  ? 90  ALA B N   1 
ATOM   2743 C CA  . ALA B 1 82  ? -28.98997 -9.84150  44.81232 1.000 49.79277  ? 90  ALA B CA  1 
ATOM   2744 C C   . ALA B 1 82  ? -28.74146 -11.16267 44.09374 1.000 51.06913  ? 90  ALA B C   1 
ATOM   2745 O O   . ALA B 1 82  ? -29.19479 -11.31797 42.95242 1.000 51.08538  ? 90  ALA B O   1 
ATOM   2746 C CB  . ALA B 1 82  ? -28.27963 -8.72703  44.05153 1.000 48.74218  ? 90  ALA B CB  1 
ATOM   2747 N N   . GLY B 1 83  ? -27.99970 -12.08658 44.69595 1.000 50.66294  ? 91  GLY B N   1 
ATOM   2748 C CA  . GLY B 1 83  ? -27.66682 -13.35806 44.08874 1.000 52.31087  ? 91  GLY B CA  1 
ATOM   2749 C C   . GLY B 1 83  ? -26.16674 -13.57807 44.08772 1.000 49.31414  ? 91  GLY B C   1 
ATOM   2750 O O   . GLY B 1 83  ? -25.39577 -12.80313 44.66539 1.000 46.86868  ? 91  GLY B O   1 
ATOM   2751 N N   . ALA B 1 84  ? -25.74185 -14.63079 43.39624 1.000 47.86434  ? 92  ALA B N   1 
ATOM   2752 C CA  . ALA B 1 84  ? -24.32616 -14.98148 43.35261 1.000 50.03866  ? 92  ALA B CA  1 
ATOM   2753 C C   . ALA B 1 84  ? -23.55399 -14.03094 42.44971 1.000 47.99358  ? 92  ALA B C   1 
ATOM   2754 O O   . ALA B 1 84  ? -24.04121 -13.59744 41.40112 1.000 48.42846  ? 92  ALA B O   1 
ATOM   2755 C CB  . ALA B 1 84  ? -24.13456 -16.42210 42.86931 1.000 48.06236  ? 92  ALA B CB  1 
ATOM   2756 N N   . TYR B 1 85  ? -22.34054 -13.70263 42.86929 1.000 45.12568  ? 93  TYR B N   1 
ATOM   2757 C CA  . TYR B 1 85  ? -21.48305 -12.81252 42.11281 1.000 46.96781  ? 93  TYR B CA  1 
ATOM   2758 C C   . TYR B 1 85  ? -20.05700 -13.35236 42.07223 1.000 51.52061  ? 93  TYR B C   1 
ATOM   2759 O O   . TYR B 1 85  ? -19.62448 -14.09988 42.95378 1.000 50.54953  ? 93  TYR B O   1 
ATOM   2760 C CB  . TYR B 1 85  ? -21.48897 -11.40258 42.71561 1.000 48.39039  ? 93  TYR B CB  1 
ATOM   2761 C CG  . TYR B 1 85  ? -22.54657 -10.53070 42.11329 1.000 49.45896  ? 93  TYR B CG  1 
ATOM   2762 C CD1 . TYR B 1 85  ? -23.86481 -10.60264 42.54402 1.000 47.81881  ? 93  TYR B CD1 1 
ATOM   2763 C CD2 . TYR B 1 85  ? -22.23906 -9.67037  41.07536 1.000 49.54124  ? 93  TYR B CD2 1 
ATOM   2764 C CE1 . TYR B 1 85  ? -24.83887 -9.81270  41.96903 1.000 46.30179  ? 93  TYR B CE1 1 
ATOM   2765 C CE2 . TYR B 1 85  ? -23.20087 -8.88159  40.49605 1.000 48.21102  ? 93  TYR B CE2 1 
ATOM   2766 C CZ  . TYR B 1 85  ? -24.49301 -8.95682  40.94252 1.000 48.33135  ? 93  TYR B CZ  1 
ATOM   2767 O OH  . TYR B 1 85  ? -25.43095 -8.15332  40.34872 1.000 49.25433  ? 93  TYR B OH  1 
ATOM   2768 N N   . ARG B 1 86  ? -19.33771 -12.96631 41.02450 1.000 50.96010  ? 94  ARG B N   1 
ATOM   2769 C CA  . ARG B 1 86  ? -17.89559 -13.13240 40.93603 1.000 48.31037  ? 94  ARG B CA  1 
ATOM   2770 C C   . ARG B 1 86  ? -17.25693 -11.78007 41.20073 1.000 46.71710  ? 94  ARG B C   1 
ATOM   2771 O O   . ARG B 1 86  ? -17.63886 -10.78367 40.58160 1.000 47.99767  ? 94  ARG B O   1 
ATOM   2772 C CB  . ARG B 1 86  ? -17.46174 -13.62967 39.55615 1.000 53.64948  ? 94  ARG B CB  1 
ATOM   2773 C CG  . ARG B 1 86  ? -16.35783 -14.69546 39.55779 1.000 56.56193  ? 94  ARG B CG  1 
ATOM   2774 C CD  . ARG B 1 86  ? -16.49908 -15.75301 38.43260 1.000 62.78272  ? 94  ARG B CD  1 
ATOM   2775 N NE  . ARG B 1 86  ? -17.79914 -16.42033 38.33844 1.000 63.19603  ? 94  ARG B NE  1 
ATOM   2776 C CZ  . ARG B 1 86  ? -18.31059 -16.88900 37.20378 1.000 57.00524  ? 94  ARG B CZ  1 
ATOM   2777 N NH1 . ARG B 1 86  ? -17.66260 -16.77763 36.05453 1.000 57.13557  ? 94  ARG B NH1 1 
ATOM   2778 N NH2 . ARG B 1 86  ? -19.48422 -17.51236 37.22692 1.000 56.76138  ? 94  ARG B NH2 1 
ATOM   2779 N N   . ALA B 1 87  ? -16.29806 -11.74174 42.12224 1.000 47.40037  ? 95  ALA B N   1 
ATOM   2780 C CA  . ALA B 1 87  ? -15.49814 -10.55229 42.37117 1.000 44.07222  ? 95  ALA B CA  1 
ATOM   2781 C C   . ALA B 1 87  ? -14.12094 -10.77576 41.77174 1.000 47.05387  ? 95  ALA B C   1 
ATOM   2782 O O   . ALA B 1 87  ? -13.55955 -11.86376 41.90726 1.000 49.06461  ? 95  ALA B O   1 
ATOM   2783 C CB  . ALA B 1 87  ? -15.37770 -10.25182 43.86683 1.000 41.90613  ? 95  ALA B CB  1 
ATOM   2784 N N   . LEU B 1 88  ? -13.59510 -9.75697  41.08484 1.000 42.20694  ? 96  LEU B N   1 
ATOM   2785 C CA  . LEU B 1 88  ? -12.36477 -9.88634  40.31942 1.000 42.56536  ? 96  LEU B CA  1 
ATOM   2786 C C   . LEU B 1 88  ? -11.51587 -8.65547  40.57967 1.000 48.34039  ? 96  LEU B C   1 
ATOM   2787 O O   . LEU B 1 88  ? -11.98621 -7.52792  40.40382 1.000 45.98342  ? 96  LEU B O   1 
ATOM   2788 C CB  . LEU B 1 88  ? -12.63839 -10.02155 38.81629 1.000 43.97563  ? 96  LEU B CB  1 
ATOM   2789 C CG  . LEU B 1 88  ? -13.57241 -11.13385 38.31810 1.000 52.44503  ? 96  LEU B CG  1 
ATOM   2790 C CD1 . LEU B 1 88  ? -13.71350 -11.09987 36.79718 1.000 50.58355  ? 96  LEU B CD1 1 
ATOM   2791 C CD2 . LEU B 1 88  ? -13.16033 -12.52396 38.79605 1.000 54.27140  ? 96  LEU B CD2 1 
ATOM   2792 N N   . LEU B 1 89  ? -10.26373 -8.86653  40.97474 1.000 48.09788  ? 97  LEU B N   1 
ATOM   2793 C CA  . LEU B 1 89  ? -9.38430  -7.78032  41.37783 1.000 45.79816  ? 97  LEU B CA  1 
ATOM   2794 C C   . LEU B 1 89  ? -8.12986  -7.76310  40.51086 1.000 48.49165  ? 97  LEU B C   1 
ATOM   2795 O O   . LEU B 1 89  ? -7.48059  -8.79819  40.32729 1.000 43.46376  ? 97  LEU B O   1 
ATOM   2796 C CB  . LEU B 1 89  ? -9.02931  -7.93742  42.85945 1.000 49.66222  ? 97  LEU B CB  1 
ATOM   2797 C CG  . LEU B 1 89  ? -8.52966  -6.76765  43.70769 1.000 55.85910  ? 97  LEU B CG  1 
ATOM   2798 C CD1 . LEU B 1 89  ? -8.77339  -7.08580  45.17784 1.000 56.68861  ? 97  LEU B CD1 1 
ATOM   2799 C CD2 . LEU B 1 89  ? -7.04540  -6.47929  43.46124 1.000 54.21477  ? 97  LEU B CD2 1 
ATOM   2800 N N   . HIS B 1 90  ? -7.78654  -6.58777  39.98589 1.000 47.47919  ? 98  HIS B N   1 
ATOM   2801 C CA  . HIS B 1 90  ? -6.49151  -6.39313  39.35141 1.000 47.66386  ? 98  HIS B CA  1 
ATOM   2802 C C   . HIS B 1 90  ? -6.03977  -4.95689  39.58288 1.000 50.74305  ? 98  HIS B C   1 
ATOM   2803 O O   . HIS B 1 90  ? -6.78710  -4.12313  40.10303 1.000 48.74681  ? 98  HIS B O   1 
ATOM   2804 C CB  . HIS B 1 90  ? -6.51002  -6.75557  37.85353 1.000 46.02715  ? 98  HIS B CB  1 
ATOM   2805 C CG  . HIS B 1 90  ? -7.23663  -5.77937  36.96634 1.000 48.93828  ? 98  HIS B CG  1 
ATOM   2806 N ND1 . HIS B 1 90  ? -8.60079  -5.82602  36.76303 1.000 42.59005  ? 98  HIS B ND1 1 
ATOM   2807 C CD2 . HIS B 1 90  ? -6.77800  -4.76330  36.19062 1.000 47.03614  ? 98  HIS B CD2 1 
ATOM   2808 C CE1 . HIS B 1 90  ? -8.95218  -4.87144  35.92058 1.000 42.25165  ? 98  HIS B CE1 1 
ATOM   2809 N NE2 . HIS B 1 90  ? -7.86517  -4.21310  35.55460 1.000 42.96676  ? 98  HIS B NE2 1 
ATOM   2810 N N   . GLU B 1 91  ? -4.78973  -4.68131  39.21186 1.000 48.73159  ? 99  GLU B N   1 
ATOM   2811 C CA  . GLU B 1 91  ? -4.19589  -3.36042  39.36312 1.000 49.95635  ? 99  GLU B CA  1 
ATOM   2812 C C   . GLU B 1 91  ? -4.03421  -2.70155  37.99530 1.000 46.26216  ? 99  GLU B C   1 
ATOM   2813 O O   . GLU B 1 91  ? -3.71442  -3.36569  37.00400 1.000 47.24220  ? 99  GLU B O   1 
ATOM   2814 C CB  . GLU B 1 91  ? -2.84896  -3.43588  40.09937 1.000 55.40753  ? 99  GLU B CB  1 
ATOM   2815 C CG  . GLU B 1 91  ? -2.93494  -3.98030  41.54214 1.000 59.55778  ? 99  GLU B CG  1 
ATOM   2816 C CD  . GLU B 1 91  ? -1.57240  -4.01289  42.27179 1.000 75.49590  ? 99  GLU B CD  1 
ATOM   2817 O OE1 . GLU B 1 91  ? -0.59127  -4.55291  41.69580 1.000 74.00995  ? 99  GLU B OE1 1 
ATOM   2818 O OE2 . GLU B 1 91  ? -1.47902  -3.49741  43.41864 1.000 73.96540  ? 99  GLU B OE2 1 
ATOM   2819 N N   . SER B 1 92  ? -4.26916  -1.39032  37.94795 1.000 45.36931  ? 100 SER B N   1 
ATOM   2820 C CA  . SER B 1 92  ? -4.18620  -0.62756  36.70908 1.000 46.15296  ? 100 SER B CA  1 
ATOM   2821 C C   . SER B 1 92  ? -4.06410  0.84489   37.06702 1.000 49.07952  ? 100 SER B C   1 
ATOM   2822 O O   . SER B 1 92  ? -4.81062  1.33460   37.92174 1.000 49.70581  ? 100 SER B O   1 
ATOM   2823 C CB  . SER B 1 92  ? -5.41772  -0.85636  35.82201 1.000 49.44582  ? 100 SER B CB  1 
ATOM   2824 O OG  . SER B 1 92  ? -5.32706  -0.11675  34.61028 1.000 48.09502  ? 100 SER B OG  1 
ATOM   2825 N N   . ASP B 1 93  ? -3.13855  1.54195   36.39916 1.000 53.61653  ? 101 ASP B N   1 
ATOM   2826 C CA  . ASP B 1 93  ? -2.88463  2.97677   36.59876 1.000 52.19997  ? 101 ASP B CA  1 
ATOM   2827 C C   . ASP B 1 93  ? -2.58888  3.31251   38.05966 1.000 51.74215  ? 101 ASP B C   1 
ATOM   2828 O O   . ASP B 1 93  ? -2.82305  4.43672   38.50553 1.000 50.83813  ? 101 ASP B O   1 
ATOM   2829 C CB  . ASP B 1 93  ? -4.05623  3.84038   36.10425 1.000 56.46426  ? 101 ASP B CB  1 
ATOM   2830 C CG  . ASP B 1 93  ? -4.08749  4.01060   34.58413 1.000 54.34600  ? 101 ASP B CG  1 
ATOM   2831 O OD1 . ASP B 1 93  ? -3.00431  4.12578   33.95559 1.000 55.04887  ? 101 ASP B OD1 1 
ATOM   2832 O OD2 . ASP B 1 93  ? -5.21149  4.09656   34.03130 1.000 48.26386  ? 101 ASP B OD2 1 
ATOM   2833 N N   . GLY B 1 94  ? -2.07541  2.35266   38.82615 1.000 53.20383  ? 102 GLY B N   1 
ATOM   2834 C CA  . GLY B 1 94  ? -1.89317  2.54899   40.24818 1.000 55.19974  ? 102 GLY B CA  1 
ATOM   2835 C C   . GLY B 1 94  ? -3.13360  2.35595   41.09364 1.000 55.96532  ? 102 GLY B C   1 
ATOM   2836 O O   . GLY B 1 94  ? -3.03811  2.39139   42.32771 1.000 58.83834  ? 102 GLY B O   1 
ATOM   2837 N N   . LEU B 1 95  ? -4.29440  2.17649   40.48253 1.000 58.13298  ? 103 LEU B N   1 
ATOM   2838 C CA  . LEU B 1 95  ? -5.50724  1.83654   41.20508 1.000 53.49696  ? 103 LEU B CA  1 
ATOM   2839 C C   . LEU B 1 95  ? -5.63992  0.32183   41.27731 1.000 54.96464  ? 103 LEU B C   1 
ATOM   2840 O O   . LEU B 1 95  ? -5.20357  -0.40015  40.37777 1.000 57.22236  ? 103 LEU B O   1 
ATOM   2841 C CB  . LEU B 1 95  ? -6.72911  2.40972   40.49721 1.000 54.72615  ? 103 LEU B CB  1 
ATOM   2842 C CG  . LEU B 1 95  ? -6.87338  3.91927   40.32011 1.000 59.56150  ? 103 LEU B CG  1 
ATOM   2843 C CD1 . LEU B 1 95  ? -6.32167  4.64685   41.52463 1.000 62.94359  ? 103 LEU B CD1 1 
ATOM   2844 C CD2 . LEU B 1 95  ? -6.20624  4.36973   39.03813 1.000 54.53290  ? 103 LEU B CD2 1 
ATOM   2845 N N   . THR B 1 96  ? -6.25215  -0.16730  42.34243 1.000 54.46907  ? 104 THR B N   1 
ATOM   2846 C CA  . THR B 1 96  ? -6.71150  -1.54981  42.36038 1.000 58.43151  ? 104 THR B CA  1 
ATOM   2847 C C   . THR B 1 96  ? -8.18792  -1.54826  41.95966 1.000 56.25317  ? 104 THR B C   1 
ATOM   2848 O O   . THR B 1 96  ? -8.99553  -0.81733  42.54278 1.000 55.34387  ? 104 THR B O   1 
ATOM   2849 C CB  . THR B 1 96  ? -6.50381  -2.21542  43.71654 1.000 60.46179  ? 104 THR B CB  1 
ATOM   2850 O OG1 . THR B 1 96  ? -7.64537  -1.98071  44.54236 1.000 61.88089  ? 104 THR B OG1 1 
ATOM   2851 C CG2 . THR B 1 96  ? -5.25843  -1.65740  44.37456 1.000 58.69922  ? 104 THR B CG2 1 
ATOM   2852 N N   . VAL B 1 97  ? -8.51195  -2.31244  40.92103 1.000 54.22586  ? 105 VAL B N   1 
ATOM   2853 C CA  . VAL B 1 97  ? -9.81804  -2.30168  40.27793 1.000 48.25175  ? 105 VAL B CA  1 
ATOM   2854 C C   . VAL B 1 97  ? -10.57217 -3.54099  40.71668 1.000 48.63079  ? 105 VAL B C   1 
ATOM   2855 O O   . VAL B 1 97  ? -10.04184 -4.65283  40.63139 1.000 50.46647  ? 105 VAL B O   1 
ATOM   2856 C CB  . VAL B 1 97  ? -9.66944  -2.27743  38.74728 1.000 48.22453  ? 105 VAL B CB  1 
ATOM   2857 C CG1 . VAL B 1 97  ? -11.00512 -2.05281  38.08541 1.000 41.96770  ? 105 VAL B CG1 1 
ATOM   2858 C CG2 . VAL B 1 97  ? -8.66277  -1.22345  38.32496 1.000 43.85156  ? 105 VAL B CG2 1 
ATOM   2859 N N   . LEU B 1 98  ? -11.81544 -3.36559  41.15100 1.000 44.81336  ? 106 LEU B N   1 
ATOM   2860 C CA  . LEU B 1 98  ? -12.66110 -4.47518  41.56516 1.000 46.08470  ? 106 LEU B CA  1 
ATOM   2861 C C   . LEU B 1 98  ? -13.86432 -4.53339  40.63707 1.000 42.19213  ? 106 LEU B C   1 
ATOM   2862 O O   . LEU B 1 98  ? -14.54092 -3.52367  40.43753 1.000 44.28009  ? 106 LEU B O   1 
ATOM   2863 C CB  . LEU B 1 98  ? -13.10406 -4.31883  43.02331 1.000 49.59550  ? 106 LEU B CB  1 
ATOM   2864 C CG  . LEU B 1 98  ? -14.17404 -5.26841  43.57991 1.000 53.97542  ? 106 LEU B CG  1 
ATOM   2865 C CD1 . LEU B 1 98  ? -13.85947 -6.72581  43.26574 1.000 46.94161  ? 106 LEU B CD1 1 
ATOM   2866 C CD2 . LEU B 1 98  ? -14.32241 -5.06790  45.08201 1.000 57.91635  ? 106 LEU B CD2 1 
ATOM   2867 N N   . GLU B 1 99  ? -14.11165 -5.70419  40.05878 1.000 41.20604  ? 107 GLU B N   1 
ATOM   2868 C CA  . GLU B 1 99  ? -15.21185 -5.91979  39.12762 1.000 43.56321  ? 107 GLU B CA  1 
ATOM   2869 C C   . GLU B 1 99  ? -16.14660 -6.97622  39.69663 1.000 44.51802  ? 107 GLU B C   1 
ATOM   2870 O O   . GLU B 1 99  ? -15.68669 -8.04735  40.10761 1.000 41.29108  ? 107 GLU B O   1 
ATOM   2871 C CB  . GLU B 1 99  ? -14.68692 -6.35979  37.75669 1.000 42.37837  ? 107 GLU B CB  1 
ATOM   2872 C CG  . GLU B 1 99  ? -13.80521 -5.32251  37.10320 1.000 40.45876  ? 107 GLU B CG  1 
ATOM   2873 C CD  . GLU B 1 99  ? -13.26456 -5.76561  35.75478 1.000 41.84550  ? 107 GLU B CD  1 
ATOM   2874 O OE1 . GLU B 1 99  ? -13.68193 -5.18627  34.73083 1.000 39.99840  ? 107 GLU B OE1 1 
ATOM   2875 O OE2 . GLU B 1 99  ? -12.40914 -6.68260  35.71147 1.000 42.91583  ? 107 GLU B OE2 1 
ATOM   2876 N N   . LEU B 1 100 ? -17.45358 -6.67213  39.74134 1.000 42.56862  ? 108 LEU B N   1 
ATOM   2877 C CA  . LEU B 1 100 ? -18.45806 -7.61883  40.22284 1.000 42.30329  ? 108 LEU B CA  1 
ATOM   2878 C C   . LEU B 1 100 ? -19.35417 -8.05616  39.07072 1.000 45.73929  ? 108 LEU B C   1 
ATOM   2879 O O   . LEU B 1 100 ? -19.97205 -7.21808  38.40364 1.000 43.05178  ? 108 LEU B O   1 
ATOM   2880 C CB  . LEU B 1 100 ? -19.30641 -7.02104  41.34590 1.000 46.88072  ? 108 LEU B CB  1 
ATOM   2881 C CG  . LEU B 1 100 ? -18.53818 -6.72390  42.62715 1.000 50.19576  ? 108 LEU B CG  1 
ATOM   2882 C CD1 . LEU B 1 100 ? -19.28890 -5.70213  43.46116 1.000 51.18773  ? 108 LEU B CD1 1 
ATOM   2883 C CD2 . LEU B 1 100 ? -18.30824 -8.01493  43.40059 1.000 46.95949  ? 108 LEU B CD2 1 
ATOM   2884 N N   . GLU B 1 101 ? -19.43422 -9.36549  38.84564 1.000 45.10922  ? 109 GLU B N   1 
ATOM   2885 C CA  . GLU B 1 101 ? -20.29439 -9.86936  37.78559 1.000 48.34301  ? 109 GLU B CA  1 
ATOM   2886 C C   . GLU B 1 101 ? -21.15095 -11.03051 38.28016 1.000 49.33375  ? 109 GLU B C   1 
ATOM   2887 O O   . GLU B 1 101 ? -20.70742 -11.83318 39.11432 1.000 46.03025  ? 109 GLU B O   1 
ATOM   2888 C CB  . GLU B 1 101 ? -19.47651 -10.30900 36.56056 1.000 46.67424  ? 109 GLU B CB  1 
ATOM   2889 C CG  . GLU B 1 101 ? -18.38023 -11.31052 36.85399 1.000 51.01773  ? 109 GLU B CG  1 
ATOM   2890 C CD  . GLU B 1 101 ? -17.80998 -11.95267 35.59048 1.000 56.52923  ? 109 GLU B CD  1 
ATOM   2891 O OE1 . GLU B 1 101 ? -17.60951 -11.22498 34.59087 1.000 51.99220  ? 109 GLU B OE1 1 
ATOM   2892 O OE2 . GLU B 1 101 ? -17.54659 -13.18604 35.60714 1.000 59.69858  ? 109 GLU B OE2 1 
ATOM   2893 N N   . PRO B 1 102 ? -22.38837 -11.13409 37.79796 1.000 47.98105  ? 110 PRO B N   1 
ATOM   2894 C CA  . PRO B 1 102 ? -23.26429 -12.21357 38.25844 1.000 47.72908  ? 110 PRO B CA  1 
ATOM   2895 C C   . PRO B 1 102 ? -22.70917 -13.57470 37.87707 1.000 47.00024  ? 110 PRO B C   1 
ATOM   2896 O O   . PRO B 1 102 ? -22.02239 -13.73504 36.86541 1.000 47.31856  ? 110 PRO B O   1 
ATOM   2897 C CB  . PRO B 1 102 ? -24.59303 -11.92675 37.54406 1.000 46.54412  ? 110 PRO B CB  1 
ATOM   2898 C CG  . PRO B 1 102 ? -24.55692 -10.42985 37.29118 1.000 44.48476  ? 110 PRO B CG  1 
ATOM   2899 C CD  . PRO B 1 102 ? -23.10606 -10.16322 36.95423 1.000 45.22410  ? 110 PRO B CD  1 
ATOM   2900 N N   . ALA B 1 103 ? -23.01806 -14.55676 38.72005 1.000 50.40746  ? 111 ALA B N   1 
ATOM   2901 C CA  . ALA B 1 103 ? -22.57897 -15.93527 38.57400 1.000 48.97439  ? 111 ALA B CA  1 
ATOM   2902 C C   . ALA B 1 103 ? -23.72944 -16.85630 38.96106 1.000 48.79527  ? 111 ALA B C   1 
ATOM   2903 O O   . ALA B 1 103 ? -24.66493 -16.45289 39.65695 1.000 47.17325  ? 111 ALA B O   1 
ATOM   2904 C CB  . ALA B 1 103 ? -21.35858 -16.22406 39.45172 1.000 47.55312  ? 111 ALA B CB  1 
ATOM   2905 N N   . GLU B 1 104 ? -23.65709 -18.09646 38.48734 1.000 51.13011  ? 112 GLU B N   1 
ATOM   2906 C CA  . GLU B 1 104 ? -24.54821 -19.14434 38.96312 1.000 55.52784  ? 112 GLU B CA  1 
ATOM   2907 C C   . GLU B 1 104 ? -24.28764 -19.42195 40.44238 1.000 60.85099  ? 112 GLU B C   1 
ATOM   2908 O O   . GLU B 1 104 ? -23.23429 -19.09019 40.98706 1.000 67.70884  ? 112 GLU B O   1 
ATOM   2909 C CB  . GLU B 1 104 ? -24.34855 -20.42574 38.15913 1.000 58.80640  ? 112 GLU B CB  1 
ATOM   2910 C CG  . GLU B 1 104 ? -24.51439 -20.25897 36.65763 1.000 59.08412  ? 112 GLU B CG  1 
ATOM   2911 C CD  . GLU B 1 104 ? -24.40879 -21.58366 35.91695 1.000 58.67632  ? 112 GLU B CD  1 
ATOM   2912 O OE1 . GLU B 1 104 ? -23.84862 -22.53874 36.50273 1.000 59.21111  ? 112 GLU B OE1 1 
ATOM   2913 O OE2 . GLU B 1 104 ? -24.88527 -21.66887 34.75763 1.000 59.51177  ? 112 GLU B OE2 1 
ATOM   2914 N N   . LEU B 1 105 ? -25.25670 -20.05585 41.09327 1.000 65.47622  ? 113 LEU B N   1 
ATOM   2915 C CA  . LEU B 1 105 ? -25.15315 -20.31054 42.52245 1.000 65.77746  ? 113 LEU B CA  1 
ATOM   2916 C C   . LEU B 1 105 ? -24.23347 -21.49441 42.81583 1.000 75.37119  ? 113 LEU B C   1 
ATOM   2917 O O   . LEU B 1 105 ? -24.18625 -22.48216 42.07203 1.000 72.05886  ? 113 LEU B O   1 
ATOM   2918 C CB  . LEU B 1 105 ? -26.54427 -20.54774 43.10531 1.000 65.77029  ? 113 LEU B CB  1 
ATOM   2919 C CG  . LEU B 1 105 ? -27.02686 -19.40765 44.00074 1.000 61.42304  ? 113 LEU B CG  1 
ATOM   2920 C CD1 . LEU B 1 105 ? -28.39787 -19.71604 44.56205 1.000 65.53964  ? 113 LEU B CD1 1 
ATOM   2921 C CD2 . LEU B 1 105 ? -26.03509 -19.15225 45.12803 1.000 64.20793  ? 113 LEU B CD2 1 
ATOM   2922 N N   . GLN B 1 106 ? -23.51300 -21.38686 43.92931 1.000 85.85938  ? 114 GLN B N   1 
ATOM   2923 C CA  . GLN B 1 106 ? -22.58302 -22.42045 44.39201 1.000 88.36102  ? 114 GLN B CA  1 
ATOM   2924 C C   . GLN B 1 106 ? -22.89979 -22.83018 45.82497 1.000 95.52797  ? 114 GLN B C   1 
ATOM   2925 O O   . GLN B 1 106 ? -22.63422 -22.04381 46.75942 1.000 96.38171  ? 114 GLN B O   1 
ATOM   2926 C CB  . GLN B 1 106 ? -21.13808 -21.93905 44.28013 1.000 85.43403  ? 114 GLN B CB  1 
ATOM   2927 C CG  . GLN B 1 106 ? -20.65421 -21.84885 42.84956 1.000 87.62660  ? 114 GLN B CG  1 
ATOM   2928 C CD  . GLN B 1 106 ? -20.71146 -23.20115 42.14939 1.000 92.27140  ? 114 GLN B CD  1 
ATOM   2929 O OE1 . GLN B 1 106 ? -20.16054 -24.18861 42.64294 1.000 92.10955  ? 114 GLN B OE1 1 
ATOM   2930 N NE2 . GLN B 1 106 ? -21.41256 -23.25959 41.01565 1.000 87.65549  ? 114 GLN B NE2 1 
ATOM   2931 N N   . PRO B 1 107 ? -23.49492 -24.02277 46.04437 1.000 99.50821  ? 115 PRO B N   1 
ATOM   2932 C CA  . PRO B 1 107 ? -23.86535 -24.61997 47.33895 1.000 101.84017 ? 115 PRO B CA  1 
ATOM   2933 C C   . PRO B 1 107 ? -22.92530 -24.26743 48.49772 1.000 100.56894 ? 115 PRO B C   1 
ATOM   2934 O O   . PRO B 1 107 ? -23.31954 -23.50222 49.38021 1.000 101.22794 ? 115 PRO B O   1 
ATOM   2935 C CB  . PRO B 1 107 ? -23.81724 -26.13512 47.05447 1.000 101.79274 ? 115 PRO B CB  1 
ATOM   2936 C CG  . PRO B 1 107 ? -23.61347 -26.28207 45.53466 1.000 101.98070 ? 115 PRO B CG  1 
ATOM   2937 C CD  . PRO B 1 107 ? -23.84670 -24.92549 44.93402 1.000 96.10241  ? 115 PRO B CD  1 
ATOM   2938 N N   . GLY B 1 129 ? -2.83322  -33.20725 11.74671 1.000 60.34589  ? 137 GLY B N   1 
ATOM   2939 C CA  . GLY B 1 129 ? -2.27486  -31.91820 11.38050 1.000 60.68440  ? 137 GLY B CA  1 
ATOM   2940 C C   . GLY B 1 129 ? -2.83040  -30.74248 12.17483 1.000 58.90591  ? 137 GLY B C   1 
ATOM   2941 O O   . GLY B 1 129 ? -3.70623  -30.90617 13.03077 1.000 55.06541  ? 137 GLY B O   1 
ATOM   2942 N N   . THR B 1 130 ? -2.33827  -29.54172 11.85109 1.000 57.04627  ? 138 THR B N   1 
ATOM   2943 C CA  . THR B 1 130 ? -2.73485  -28.34790 12.58842 1.000 53.97928  ? 138 THR B CA  1 
ATOM   2944 C C   . THR B 1 130 ? -4.20968  -28.01229 12.38743 1.000 52.41233  ? 138 THR B C   1 
ATOM   2945 O O   . THR B 1 130 ? -4.89051  -27.62463 13.34301 1.000 49.32595  ? 138 THR B O   1 
ATOM   2946 C CB  . THR B 1 130 ? -1.84437  -27.16711 12.18857 1.000 56.39903  ? 138 THR B CB  1 
ATOM   2947 O OG1 . THR B 1 130 ? -2.00511  -26.10255 13.13581 1.000 58.94259  ? 138 THR B OG1 1 
ATOM   2948 C CG2 . THR B 1 130 ? -2.15436  -26.66588 10.78417 1.000 58.51429  ? 138 THR B CG2 1 
ATOM   2949 N N   . GLN B 1 131 ? -4.72961  -28.16391 11.16640 1.000 53.99836  ? 139 GLN B N   1 
ATOM   2950 C CA  . GLN B 1 131 ? -6.14557  -27.90024 10.94849 1.000 49.58121  ? 139 GLN B CA  1 
ATOM   2951 C C   . GLN B 1 131 ? -7.00253  -28.88581 11.73652 1.000 49.80722  ? 139 GLN B C   1 
ATOM   2952 O O   . GLN B 1 131 ? -8.06632  -28.52013 12.25683 1.000 47.69996  ? 139 GLN B O   1 
ATOM   2953 C CB  . GLN B 1 131 ? -6.47993  -27.95736 9.45675  1.000 46.53596  ? 139 GLN B CB  1 
ATOM   2954 C CG  . GLN B 1 131 ? -7.92004  -27.57005 9.15186  1.000 47.07373  ? 139 GLN B CG  1 
ATOM   2955 C CD  . GLN B 1 131 ? -8.91909  -28.70107 9.36012  1.000 54.76937  ? 139 GLN B CD  1 
ATOM   2956 O OE1 . GLN B 1 131 ? -8.53632  -29.86673 9.52362  1.000 52.00753  ? 139 GLN B OE1 1 
ATOM   2957 N NE2 . GLN B 1 131 ? -10.21629 -28.34799 9.42485  1.000 60.64325  ? 139 GLN B NE2 1 
ATOM   2958 N N   . ALA B 1 132 ? -6.56513  -30.14715 11.81587 1.000 45.64956  ? 140 ALA B N   1 
ATOM   2959 C CA  . ALA B 1 132 ? -7.31372  -31.15241 12.56239 1.000 45.74527  ? 140 ALA B CA  1 
ATOM   2960 C C   . ALA B 1 132 ? -7.30446  -30.86416 14.05506 1.000 46.13375  ? 140 ALA B C   1 
ATOM   2961 O O   . ALA B 1 132 ? -8.29915  -31.11991 14.74670 1.000 45.89370  ? 140 ALA B O   1 
ATOM   2962 C CB  . ALA B 1 132 ? -6.76141  -32.54882 12.28365 1.000 47.14048  ? 140 ALA B CB  1 
ATOM   2963 N N   . LEU B 1 133 ? -6.18004  -30.38114 14.58138 1.000 44.51519  ? 141 LEU B N   1 
ATOM   2964 C CA  . LEU B 1 133 ? -6.13296  -30.01000 15.99135 1.000 42.28256  ? 141 LEU B CA  1 
ATOM   2965 C C   . LEU B 1 133 ? -7.08240  -28.85842 16.29201 1.000 41.40934  ? 141 LEU B C   1 
ATOM   2966 O O   . LEU B 1 133 ? -7.78699  -28.87656 17.30605 1.000 40.40470  ? 141 LEU B O   1 
ATOM   2967 C CB  . LEU B 1 133 ? -4.70774  -29.64871 16.39956 1.000 44.34961  ? 141 LEU B CB  1 
ATOM   2968 C CG  . LEU B 1 133 ? -4.66415  -28.84787 17.70326 1.000 45.33690  ? 141 LEU B CG  1 
ATOM   2969 C CD1 . LEU B 1 133 ? -5.04707  -29.73626 18.88071 1.000 44.40142  ? 141 LEU B CD1 1 
ATOM   2970 C CD2 . LEU B 1 133 ? -3.29866  -28.24286 17.92687 1.000 45.07215  ? 141 LEU B CD2 1 
ATOM   2971 N N   . LEU B 1 134 ? -7.10151  -27.83425 15.43403 1.000 41.94679  ? 142 LEU B N   1 
ATOM   2972 C CA  . LEU B 1 134 ? -7.99362  -26.70637 15.66042 1.000 39.66990  ? 142 LEU B CA  1 
ATOM   2973 C C   . LEU B 1 134 ? -9.44762  -27.06385 15.35248 1.000 36.56651  ? 142 LEU B C   1 
ATOM   2974 O O   . LEU B 1 134 ? -10.36561 -26.41941 15.87919 1.000 36.39625  ? 142 LEU B O   1 
ATOM   2975 C CB  . LEU B 1 134 ? -7.52617  -25.49965 14.83278 1.000 42.23925  ? 142 LEU B CB  1 
ATOM   2976 C CG  . LEU B 1 134 ? -6.42174  -24.60148 15.46035 1.000 41.42925  ? 142 LEU B CG  1 
ATOM   2977 C CD1 . LEU B 1 134 ? -6.74766  -24.19473 16.87353 1.000 45.82367  ? 142 LEU B CD1 1 
ATOM   2978 C CD2 . LEU B 1 134 ? -5.10799  -25.26033 15.48835 1.000 43.72962  ? 142 LEU B CD2 1 
ATOM   2979 N N   . GLN B 1 135 ? -9.68769  -28.08723 14.53012 1.000 40.72874  ? 143 GLN B N   1 
ATOM   2980 C CA  . GLN B 1 135 ? -11.06031 -28.55944 14.35528 1.000 38.31749  ? 143 GLN B CA  1 
ATOM   2981 C C   . GLN B 1 135 ? -11.61245 -29.13978 15.65429 1.000 39.42095  ? 143 GLN B C   1 
ATOM   2982 O O   . GLN B 1 135 ? -12.75372 -28.83368 16.04225 1.000 37.56568  ? 143 GLN B O   1 
ATOM   2983 C CB  . GLN B 1 135 ? -11.13889 -29.58084 13.22266 1.000 39.37143  ? 143 GLN B CB  1 
ATOM   2984 C CG  . GLN B 1 135 ? -12.57421 -30.10413 12.96706 1.000 46.61440  ? 143 GLN B CG  1 
ATOM   2985 C CD  . GLN B 1 135 ? -13.57944 -28.98992 12.64706 1.000 45.39292  ? 143 GLN B CD  1 
ATOM   2986 O OE1 . GLN B 1 135 ? -13.33194 -28.12249 11.80703 1.000 47.13695  ? 143 GLN B OE1 1 
ATOM   2987 N NE2 . GLN B 1 135 ? -14.71564 -29.01103 13.32870 1.000 46.72610  ? 143 GLN B NE2 1 
ATOM   2988 N N   . THR B 1 136 ? -10.82079 -29.96905 16.35494 1.000 34.55846  ? 144 THR B N   1 
ATOM   2989 C CA  . THR B 1 136 ? -11.28621 -30.49902 17.63612 1.000 35.34186  ? 144 THR B CA  1 
ATOM   2990 C C   . THR B 1 136 ? -11.41135 -29.39918 18.67098 1.000 38.06041  ? 144 THR B C   1 
ATOM   2991 O O   . THR B 1 136 ? -12.33171 -29.42653 19.50693 1.000 38.17068  ? 144 THR B O   1 
ATOM   2992 C CB  . THR B 1 136 ? -10.37110 -31.60541 18.17067 1.000 37.73097  ? 144 THR B CB  1 
ATOM   2993 O OG1 . THR B 1 136 ? -9.01210  -31.12550 18.28180 1.000 40.28150  ? 144 THR B OG1 1 
ATOM   2994 C CG2 . THR B 1 136 ? -10.44141 -32.81620 17.28009 1.000 37.36532  ? 144 THR B CG2 1 
ATOM   2995 N N   . ALA B 1 137 ? -10.50338 -28.41981 18.62684 1.000 33.91115  ? 145 ALA B N   1 
ATOM   2996 C CA  . ALA B 1 137 ? -10.61485 -27.27268 19.51972 1.000 37.55553  ? 145 ALA B CA  1 
ATOM   2997 C C   . ALA B 1 137 ? -11.93158 -26.52621 19.29566 1.000 31.65454  ? 145 ALA B C   1 
ATOM   2998 O O   . ALA B 1 137 ? -12.65222 -26.22144 20.24831 1.000 33.17990  ? 145 ALA B O   1 
ATOM   2999 C CB  . ALA B 1 137 ? -9.39836  -26.35281 19.33295 1.000 38.00732  ? 145 ALA B CB  1 
ATOM   3000 N N   . ALA B 1 138 ? -12.27454 -26.24932 18.03816 1.000 32.75782  ? 146 ALA B N   1 
ATOM   3001 C CA  . ALA B 1 138 ? -13.57284 -25.66228 17.71523 1.000 35.12565  ? 146 ALA B CA  1 
ATOM   3002 C C   . ALA B 1 138 ? -14.74410 -26.47332 18.29024 1.000 34.31432  ? 146 ALA B C   1 
ATOM   3003 O O   . ALA B 1 138 ? -15.62152 -25.91477 18.95985 1.000 30.28774  ? 146 ALA B O   1 
ATOM   3004 C CB  . ALA B 1 138 ? -13.70394 -25.51166 16.19597 1.000 38.23926  ? 146 ALA B CB  1 
ATOM   3005 N N   . ASP B 1 139 ? -14.76569 -27.79561 18.06616 1.000 35.66296  ? 147 ASP B N   1 
ATOM   3006 C CA  . ASP B 1 139 ? -15.85698 -28.62034 18.61067 1.000 33.24171  ? 147 ASP B CA  1 
ATOM   3007 C C   . ASP B 1 139 ? -15.82905 -28.66651 20.12825 1.000 34.26553  ? 147 ASP B C   1 
ATOM   3008 O O   . ASP B 1 139 ? -16.88010 -28.75070 20.76725 1.000 33.30127  ? 147 ASP B O   1 
ATOM   3009 C CB  . ASP B 1 139 ? -15.79104 -30.05482 18.08047 1.000 37.11793  ? 147 ASP B CB  1 
ATOM   3010 C CG  . ASP B 1 139 ? -16.09010 -30.14468 16.60233 1.000 39.72802  ? 147 ASP B CG  1 
ATOM   3011 O OD1 . ASP B 1 139 ? -17.06601 -29.49883 16.15661 1.000 42.10631  ? 147 ASP B OD1 1 
ATOM   3012 O OD2 . ASP B 1 139 ? -15.32942 -30.84700 15.88844 1.000 40.87905  ? 147 ASP B OD2 1 
ATOM   3013 N N   . THR B 1 140 ? -14.64475 -28.62223 20.72725 1.000 34.73323  ? 148 THR B N   1 
ATOM   3014 C CA  . THR B 1 140 ? -14.56905 -28.64562 22.18375 1.000 35.32206  ? 148 THR B CA  1 
ATOM   3015 C C   . THR B 1 140 ? -15.12279 -27.35859 22.79664 1.000 33.57001  ? 148 THR B C   1 
ATOM   3016 O O   . THR B 1 140 ? -15.86193 -27.40177 23.78756 1.000 36.30202  ? 148 THR B O   1 
ATOM   3017 C CB  . THR B 1 140 ? -13.12176 -28.88667 22.60492 1.000 36.75158  ? 148 THR B CB  1 
ATOM   3018 O OG1 . THR B 1 140 ? -12.69197 -30.12336 22.02320 1.000 38.23297  ? 148 THR B OG1 1 
ATOM   3019 C CG2 . THR B 1 140 ? -12.99769 -28.96455 24.11395 1.000 33.15831  ? 148 THR B CG2 1 
ATOM   3020 N N   . VAL B 1 141 ? -14.76964 -26.20513 22.23132 1.000 32.39860  ? 149 VAL B N   1 
ATOM   3021 C CA  . VAL B 1 141 ? -15.25691 -24.93501 22.75732 1.000 32.23759  ? 149 VAL B CA  1 
ATOM   3022 C C   . VAL B 1 141 ? -16.77006 -24.79326 22.53203 1.000 34.89681  ? 149 VAL B C   1 
ATOM   3023 O O   . VAL B 1 141 ? -17.50451 -24.32389 23.41495 1.000 31.42015  ? 149 VAL B O   1 
ATOM   3024 C CB  . VAL B 1 141 ? -14.45114 -23.78813 22.12906 1.000 33.20862  ? 149 VAL B CB  1 
ATOM   3025 C CG1 . VAL B 1 141 ? -15.00976 -22.42935 22.53261 1.000 30.89466  ? 149 VAL B CG1 1 
ATOM   3026 C CG2 . VAL B 1 141 ? -13.01924 -23.90380 22.57214 1.000 30.10743  ? 149 VAL B CG2 1 
ATOM   3027 N N   . ARG B 1 142 ? -17.26896 -25.21352 21.36726 1.000 34.00533  ? 150 ARG B N   1 
ATOM   3028 C CA  . ARG B 1 142 ? -18.71530 -25.15232 21.15490 1.000 37.92170  ? 150 ARG B CA  1 
ATOM   3029 C C   . ARG B 1 142 ? -19.47583 -26.00885 22.16743 1.000 35.34863  ? 150 ARG B C   1 
ATOM   3030 O O   . ARG B 1 142 ? -20.55453 -25.62377 22.62696 1.000 33.35109  ? 150 ARG B O   1 
ATOM   3031 C CB  . ARG B 1 142 ? -19.09047 -25.56084 19.73161 1.000 37.11104  ? 150 ARG B CB  1 
ATOM   3032 C CG  . ARG B 1 142 ? -20.61896 -25.39787 19.53128 1.000 39.84419  ? 150 ARG B CG  1 
ATOM   3033 C CD  . ARG B 1 142 ? -21.02379 -25.42084 18.08563 1.000 42.57072  ? 150 ARG B CD  1 
ATOM   3034 N NE  . ARG B 1 142 ? -21.06345 -26.79569 17.60816 1.000 45.30028  ? 150 ARG B NE  1 
ATOM   3035 C CZ  . ARG B 1 142 ? -22.10438 -27.60330 17.74756 1.000 45.46550  ? 150 ARG B CZ  1 
ATOM   3036 N NH1 . ARG B 1 142 ? -23.22318 -27.19036 18.32499 1.000 41.93084  ? 150 ARG B NH1 1 
ATOM   3037 N NH2 . ARG B 1 142 ? -22.01682 -28.85525 17.29675 1.000 41.73952  ? 150 ARG B NH2 1 
ATOM   3038 N N   . ALA B 1 143 ? -18.92848 -27.16188 22.54326 1.000 34.93337  ? 151 ALA B N   1 
ATOM   3039 C CA  . ALA B 1 143 ? -19.56326 -27.96612 23.58623 1.000 32.19757  ? 151 ALA B CA  1 
ATOM   3040 C C   . ALA B 1 143 ? -19.44587 -27.31484 24.96608 1.000 37.71812  ? 151 ALA B C   1 
ATOM   3041 O O   . ALA B 1 143 ? -20.33802 -27.49263 25.80669 1.000 34.81327  ? 151 ALA B O   1 
ATOM   3042 C CB  . ALA B 1 143 ? -18.95076 -29.36799 23.61903 1.000 34.19295  ? 151 ALA B CB  1 
ATOM   3043 N N   . LEU B 1 144 ? -18.33228 -26.61359 25.24791 1.000 32.73517  ? 152 LEU B N   1 
ATOM   3044 C CA  . LEU B 1 144 ? -18.16697 -26.01490 26.56942 1.000 32.23194  ? 152 LEU B CA  1 
ATOM   3045 C C   . LEU B 1 144 ? -19.04632 -24.76887 26.73733 1.000 33.26129  ? 152 LEU B C   1 
ATOM   3046 O O   . LEU B 1 144 ? -19.64675 -24.56605 27.79854 1.000 36.17548  ? 152 LEU B O   1 
ATOM   3047 C CB  . LEU B 1 144 ? -16.68939 -25.68140 26.81723 1.000 30.84517  ? 152 LEU B CB  1 
ATOM   3048 C CG  . LEU B 1 144 ? -15.83055 -26.82932 27.37924 1.000 34.93058  ? 152 LEU B CG  1 
ATOM   3049 C CD1 . LEU B 1 144 ? -14.30869 -26.53098 27.25471 1.000 33.22808  ? 152 LEU B CD1 1 
ATOM   3050 C CD2 . LEU B 1 144 ? -16.20815 -27.09196 28.83067 1.000 33.22149  ? 152 LEU B CD2 1 
ATOM   3051 N N   . THR B 1 145 ? -19.15544 -23.93877 25.69931 1.000 30.93655  ? 153 THR B N   1 
ATOM   3052 C CA  . THR B 1 145 ? -19.92663 -22.71099 25.78828 1.000 31.78814  ? 153 THR B CA  1 
ATOM   3053 C C   . THR B 1 145 ? -21.40564 -22.89807 25.46817 1.000 41.37176  ? 153 THR B C   1 
ATOM   3054 O O   . THR B 1 145 ? -22.25321 -22.16865 26.00957 1.000 43.72280  ? 153 THR B O   1 
ATOM   3055 C CB  . THR B 1 145 ? -19.34263 -21.68105 24.83185 1.000 33.24679  ? 153 THR B CB  1 
ATOM   3056 O OG1 . THR B 1 145 ? -19.47033 -22.17527 23.49020 1.000 29.25250  ? 153 THR B OG1 1 
ATOM   3057 C CG2 . THR B 1 145 ? -17.86135 -21.40626 25.17129 1.000 34.72565  ? 153 THR B CG2 1 
ATOM   3058 N N   . GLY B 1 146 ? -21.74027 -23.86998 24.62026 1.000 40.94745  ? 154 GLY B N   1 
ATOM   3059 C CA  . GLY B 1 146 ? -23.07683 -23.98763 24.09583 1.000 39.11247  ? 154 GLY B CA  1 
ATOM   3060 C C   . GLY B 1 146 ? -23.42286 -22.96709 23.03706 1.000 42.64149  ? 154 GLY B C   1 
ATOM   3061 O O   . GLY B 1 146 ? -24.55917 -22.95789 22.58066 1.000 40.36985  ? 154 GLY B O   1 
ATOM   3062 N N   . PHE B 1 147 ? -22.48825 -22.10986 22.62188 1.000 38.80088  ? 155 PHE B N   1 
ATOM   3063 C CA  . PHE B 1 147 ? -22.82075 -21.08371 21.63731 1.000 40.16578  ? 155 PHE B CA  1 
ATOM   3064 C C   . PHE B 1 147 ? -23.07118 -21.68880 20.26208 1.000 40.85005  ? 155 PHE B C   1 
ATOM   3065 O O   . PHE B 1 147 ? -22.37777 -22.61418 19.83658 1.000 43.89921  ? 155 PHE B O   1 
ATOM   3066 C CB  . PHE B 1 147 ? -21.70327 -20.03906 21.51740 1.000 37.51635  ? 155 PHE B CB  1 
ATOM   3067 C CG  . PHE B 1 147 ? -21.70656 -19.00551 22.61107 1.000 39.54322  ? 155 PHE B CG  1 
ATOM   3068 C CD1 . PHE B 1 147 ? -22.22979 -19.29711 23.86531 1.000 36.19653  ? 155 PHE B CD1 1 
ATOM   3069 C CD2 . PHE B 1 147 ? -21.15333 -17.74646 22.39150 1.000 32.66135  ? 155 PHE B CD2 1 
ATOM   3070 C CE1 . PHE B 1 147 ? -22.20591 -18.35547 24.87695 1.000 37.24184  ? 155 PHE B CE1 1 
ATOM   3071 C CE2 . PHE B 1 147 ? -21.13811 -16.79856 23.39132 1.000 31.98416  ? 155 PHE B CE2 1 
ATOM   3072 C CZ  . PHE B 1 147 ? -21.66478 -17.09868 24.63802 1.000 34.59333  ? 155 PHE B CZ  1 
ATOM   3073 N N   . ASP B 1 148 ? -23.97203 -21.03988 19.51635 1.000 38.03554  ? 156 ASP B N   1 
ATOM   3074 C CA  . ASP B 1 148 ? -24.40034 -21.50351 18.19621 1.000 43.22912  ? 156 ASP B CA  1 
ATOM   3075 C C   . ASP B 1 148 ? -23.23922 -21.79502 17.26177 1.000 46.70292  ? 156 ASP B C   1 
ATOM   3076 O O   . ASP B 1 148 ? -23.25045 -22.80510 16.54858 1.000 47.96058  ? 156 ASP B O   1 
ATOM   3077 C CB  . ASP B 1 148 ? -25.31011 -20.46014 17.54755 1.000 42.28155  ? 156 ASP B CB  1 
ATOM   3078 C CG  . ASP B 1 148 ? -26.68749 -20.40146 18.19150 1.000 47.47627  ? 156 ASP B CG  1 
ATOM   3079 O OD1 . ASP B 1 148 ? -27.15554 -21.46325 18.64546 1.000 44.85121  ? 156 ASP B OD1 1 
ATOM   3080 O OD2 . ASP B 1 148 ? -27.27968 -19.28998 18.25421 1.000 46.33420  ? 156 ASP B OD2 1 
ATOM   3081 N N   . ARG B 1 149 ? -22.27184 -20.87969 17.18748 1.000 40.35163  ? 157 ARG B N   1 
ATOM   3082 C CA  . ARG B 1 149 ? -21.20163 -20.96818 16.21121 1.000 42.25394  ? 157 ARG B CA  1 
ATOM   3083 C C   . ARG B 1 149 ? -19.87425 -20.67557 16.89174 1.000 44.29103  ? 157 ARG B C   1 
ATOM   3084 O O   . ARG B 1 149 ? -19.80348 -19.82756 17.79406 1.000 40.38937  ? 157 ARG B O   1 
ATOM   3085 C CB  . ARG B 1 149 ? -21.39592 -19.99744 15.05186 1.000 44.70406  ? 157 ARG B CB  1 
ATOM   3086 C CG  . ARG B 1 149 ? -20.45391 -20.28206 13.90149 1.000 53.12004  ? 157 ARG B CG  1 
ATOM   3087 C CD  . ARG B 1 149 ? -20.46619 -19.16386 12.88369 1.000 63.85978  ? 157 ARG B CD  1 
ATOM   3088 N NE  . ARG B 1 149 ? -20.52718 -17.85227 13.51384 1.000 62.80386  ? 157 ARG B NE  1 
ATOM   3089 C CZ  . ARG B 1 149 ? -20.57786 -16.70825 12.84438 1.000 69.69234  ? 157 ARG B CZ  1 
ATOM   3090 N NH1 . ARG B 1 149 ? -20.50604 -16.67931 11.52380 1.000 75.74034  ? 157 ARG B NH1 1 
ATOM   3091 N NH2 . ARG B 1 149 ? -20.70588 -15.56432 13.51492 1.000 64.61354  ? 157 ARG B NH2 1 
ATOM   3092 N N   . VAL B 1 150 ? -18.83645 -21.40629 16.46744 1.000 44.53899  ? 158 VAL B N   1 
ATOM   3093 C CA  . VAL B 1 150 ? -17.46533 -21.22674 16.93729 1.000 43.56978  ? 158 VAL B CA  1 
ATOM   3094 C C   . VAL B 1 150 ? -16.55021 -21.21800 15.72193 1.000 42.49632  ? 158 VAL B C   1 
ATOM   3095 O O   . VAL B 1 150 ? -16.63522 -22.11410 14.87605 1.000 46.33295  ? 158 VAL B O   1 
ATOM   3096 C CB  . VAL B 1 150 ? -17.05253 -22.33509 17.92599 1.000 38.87924  ? 158 VAL B CB  1 
ATOM   3097 C CG1 . VAL B 1 150 ? -15.55382 -22.31354 18.16249 1.000 35.90597  ? 158 VAL B CG1 1 
ATOM   3098 C CG2 . VAL B 1 150 ? -17.80413 -22.15456 19.24142 1.000 37.10470  ? 158 VAL B CG2 1 
ATOM   3099 N N   . MET B 1 151 ? -15.68982 -20.20232 15.62723 1.000 45.13731  ? 159 MET B N   1 
ATOM   3100 C CA  . MET B 1 151 ? -14.73200 -20.05770 14.53133 1.000 46.99229  ? 159 MET B CA  1 
ATOM   3101 C C   . MET B 1 151 ? -13.30359 -19.99227 15.06228 1.000 42.21630  ? 159 MET B C   1 
ATOM   3102 O O   . MET B 1 151 ? -13.04557 -19.36382 16.09306 1.000 39.54227  ? 159 MET B O   1 
ATOM   3103 C CB  . MET B 1 151 ? -15.01847 -18.79229 13.73034 1.000 45.73239  ? 159 MET B CB  1 
ATOM   3104 C CG  . MET B 1 151 ? -16.49111 -18.65147 13.36234 1.000 55.46859  ? 159 MET B CG  1 
ATOM   3105 S SD  . MET B 1 151 ? -16.74917 -18.20029 11.65003 1.000 70.78327  ? 159 MET B SD  1 
ATOM   3106 C CE  . MET B 1 151 ? -16.20584 -19.70833 10.87794 1.000 66.04847  ? 159 MET B CE  1 
ATOM   3107 N N   . VAL B 1 152 ? -12.37258 -20.61630 14.34028 1.000 40.37017  ? 160 VAL B N   1 
ATOM   3108 C CA  . VAL B 1 152 ? -10.95109 -20.56151 14.66502 1.000 40.84446  ? 160 VAL B CA  1 
ATOM   3109 C C   . VAL B 1 152 ? -10.24611 -19.76745 13.57226 1.000 40.92290  ? 160 VAL B C   1 
ATOM   3110 O O   . VAL B 1 152 ? -10.20423 -20.19421 12.41149 1.000 42.44891  ? 160 VAL B O   1 
ATOM   3111 C CB  . VAL B 1 152 ? -10.32768 -21.96189 14.80032 1.000 38.10016  ? 160 VAL B CB  1 
ATOM   3112 C CG1 . VAL B 1 152 ? -8.86992  -21.82482 15.17780 1.000 37.75349  ? 160 VAL B CG1 1 
ATOM   3113 C CG2 . VAL B 1 152 ? -11.06351 -22.79195 15.85268 1.000 38.20240  ? 160 VAL B CG2 1 
ATOM   3114 N N   . TYR B 1 153 ? -9.66168  -18.63249 13.94346 1.000 36.38338  ? 161 TYR B N   1 
ATOM   3115 C CA  . TYR B 1 153 ? -8.85005  -17.85945 13.01903 1.000 37.70804  ? 161 TYR B CA  1 
ATOM   3116 C C   . TYR B 1 153 ? -7.38000  -18.10413 13.32458 1.000 41.16977  ? 161 TYR B C   1 
ATOM   3117 O O   . TYR B 1 153 ? -6.99259  -18.21058 14.49045 1.000 40.75949  ? 161 TYR B O   1 
ATOM   3118 C CB  . TYR B 1 153 ? -9.13769  -16.35849 13.11563 1.000 42.91757  ? 161 TYR B CB  1 
ATOM   3119 C CG  . TYR B 1 153 ? -10.58491 -15.91116 12.92673 1.000 42.80091  ? 161 TYR B CG  1 
ATOM   3120 C CD1 . TYR B 1 153 ? -11.44057 -15.77477 14.01426 1.000 41.34667  ? 161 TYR B CD1 1 
ATOM   3121 C CD2 . TYR B 1 153 ? -11.07505 -15.59735 11.66851 1.000 47.44665  ? 161 TYR B CD2 1 
ATOM   3122 C CE1 . TYR B 1 153 ? -12.74711 -15.35620 13.85584 1.000 45.83594  ? 161 TYR B CE1 1 
ATOM   3123 C CE2 . TYR B 1 153 ? -12.38751 -15.17742 11.49369 1.000 51.74484  ? 161 TYR B CE2 1 
ATOM   3124 C CZ  . TYR B 1 153 ? -13.21935 -15.05652 12.59271 1.000 52.27684  ? 161 TYR B CZ  1 
ATOM   3125 O OH  . TYR B 1 153 ? -14.52246 -14.62822 12.43543 1.000 49.35022  ? 161 TYR B OH  1 
ATOM   3126 N N   . ARG B 1 154 ? -6.56415  -18.18892 12.27816 1.000 39.56553  ? 162 ARG B N   1 
ATOM   3127 C CA  . ARG B 1 154 ? -5.11688  -18.12041 12.41509 1.000 44.01853  ? 162 ARG B CA  1 
ATOM   3128 C C   . ARG B 1 154 ? -4.62945  -16.86669 11.71749 1.000 42.49724  ? 162 ARG B C   1 
ATOM   3129 O O   . ARG B 1 154 ? -5.04375  -16.57390 10.59538 1.000 47.78159  ? 162 ARG B O   1 
ATOM   3130 C CB  . ARG B 1 154 ? -4.40899  -19.33774 11.82622 1.000 41.45196  ? 162 ARG B CB  1 
ATOM   3131 C CG  . ARG B 1 154 ? -2.88940  -19.19472 11.84321 1.000 44.68137  ? 162 ARG B CG  1 
ATOM   3132 C CD  . ARG B 1 154 ? -2.24764  -20.51852 11.49237 1.000 42.86555  ? 162 ARG B CD  1 
ATOM   3133 N NE  . ARG B 1 154 ? -2.66800  -20.96065 10.17247 1.000 51.40124  ? 162 ARG B NE  1 
ATOM   3134 C CZ  . ARG B 1 154 ? -2.27608  -22.09003 9.59692  1.000 61.91631  ? 162 ARG B CZ  1 
ATOM   3135 N NH1 . ARG B 1 154 ? -1.46333  -22.93811 10.21471 1.000 61.33391  ? 162 ARG B NH1 1 
ATOM   3136 N NH2 . ARG B 1 154 ? -2.71117  -22.37718 8.37144  1.000 63.50127  ? 162 ARG B NH2 1 
ATOM   3137 N N   . PHE B 1 155 ? -3.75979  -16.12862 12.38120 1.000 39.77982  ? 163 PHE B N   1 
ATOM   3138 C CA  . PHE B 1 155 ? -3.25909  -14.89258 11.80771 1.000 45.02903  ? 163 PHE B CA  1 
ATOM   3139 C C   . PHE B 1 155 ? -2.09040  -15.19329 10.88280 1.000 45.63336  ? 163 PHE B C   1 
ATOM   3140 O O   . PHE B 1 155 ? -1.15356  -15.89852 11.26879 1.000 46.18395  ? 163 PHE B O   1 
ATOM   3141 C CB  . PHE B 1 155 ? -2.84021  -13.93771 12.91933 1.000 41.71621  ? 163 PHE B CB  1 
ATOM   3142 C CG  . PHE B 1 155 ? -3.99378  -13.38359 13.67773 1.000 40.79081  ? 163 PHE B CG  1 
ATOM   3143 C CD1 . PHE B 1 155 ? -4.86524  -12.50781 13.07032 1.000 41.01531  ? 163 PHE B CD1 1 
ATOM   3144 C CD2 . PHE B 1 155 ? -4.22553  -13.76168 14.98311 1.000 36.70500  ? 163 PHE B CD2 1 
ATOM   3145 C CE1 . PHE B 1 155 ? -5.93116  -12.00646 13.75265 1.000 40.29132  ? 163 PHE B CE1 1 
ATOM   3146 C CE2 . PHE B 1 155 ? -5.29777  -13.27478 15.66267 1.000 37.65157  ? 163 PHE B CE2 1 
ATOM   3147 C CZ  . PHE B 1 155 ? -6.14569  -12.38282 15.05760 1.000 35.99257  ? 163 PHE B CZ  1 
ATOM   3148 N N   . ASP B 1 156 ? -2.14244  -14.66056 9.66511  1.000 45.89768  ? 164 ASP B N   1 
ATOM   3149 C CA  . ASP B 1 156 ? -1.03614  -14.83353 8.73598  1.000 52.34118  ? 164 ASP B CA  1 
ATOM   3150 C C   . ASP B 1 156 ? 0.00901   -13.74178 9.00084  1.000 48.77191  ? 164 ASP B C   1 
ATOM   3151 O O   . ASP B 1 156 ? -0.04768  -13.03890 10.01347 1.000 48.91475  ? 164 ASP B O   1 
ATOM   3152 C CB  . ASP B 1 156 ? -1.55993  -14.87570 7.29612  1.000 49.23352  ? 164 ASP B CB  1 
ATOM   3153 C CG  . ASP B 1 156 ? -2.08460  -13.53987 6.79996  1.000 49.25655  ? 164 ASP B CG  1 
ATOM   3154 O OD1 . ASP B 1 156 ? -1.89140  -12.49863 7.45677  1.000 50.19968  ? 164 ASP B OD1 1 
ATOM   3155 O OD2 . ASP B 1 156 ? -2.70481  -13.53944 5.71796  1.000 56.14893  ? 164 ASP B OD2 1 
ATOM   3156 N N   . ALA B 1 157 ? 0.98096   -13.58714 8.09820  1.000 48.69916  ? 165 ALA B N   1 
ATOM   3157 C CA  . ALA B 1 157 ? 2.07833   -12.64102 8.32355  1.000 49.88192  ? 165 ALA B CA  1 
ATOM   3158 C C   . ALA B 1 157 ? 1.64693   -11.18041 8.22995  1.000 54.61922  ? 165 ALA B C   1 
ATOM   3159 O O   . ALA B 1 157 ? 2.33806   -10.30737 8.76683  1.000 59.21040  ? 165 ALA B O   1 
ATOM   3160 C CB  . ALA B 1 157 ? 3.21042   -12.89246 7.33092  1.000 52.89688  ? 165 ALA B CB  1 
ATOM   3161 N N   . ASP B 1 158 ? 0.54082   -10.88569 7.55611  1.000 54.09444  ? 166 ASP B N   1 
ATOM   3162 C CA  . ASP B 1 158 ? -0.00656  -9.53946  7.54175  1.000 54.97972  ? 166 ASP B CA  1 
ATOM   3163 C C   . ASP B 1 158 ? -1.02655  -9.32796  8.64617  1.000 54.08715  ? 166 ASP B C   1 
ATOM   3164 O O   . ASP B 1 158 ? -1.78539  -8.35277  8.59456  1.000 54.07566  ? 166 ASP B O   1 
ATOM   3165 C CB  . ASP B 1 158 ? -0.64967  -9.23019  6.18778  1.000 58.90832  ? 166 ASP B CB  1 
ATOM   3166 C CG  . ASP B 1 158 ? 0.31980   -9.38167  5.03018  1.000 59.64095  ? 166 ASP B CG  1 
ATOM   3167 O OD1 . ASP B 1 158 ? 1.54176   -9.22991  5.24481  1.000 58.60320  ? 166 ASP B OD1 1 
ATOM   3168 O OD2 . ASP B 1 158 ? -0.15082  -9.63373  3.89992  1.000 65.79409  ? 166 ASP B OD2 1 
ATOM   3169 N N   . TRP B 1 159 ? -1.07649  -10.24023 9.62029  1.000 50.06511  ? 167 TRP B N   1 
ATOM   3170 C CA  . TRP B 1 159 ? -2.03116  -10.19662 10.72621 1.000 51.91747  ? 167 TRP B CA  1 
ATOM   3171 C C   . TRP B 1 159 ? -3.48043  -10.15601 10.23591 1.000 50.51880  ? 167 TRP B C   1 
ATOM   3172 O O   . TRP B 1 159 ? -4.34719  -9.55873  10.88645 1.000 47.33703  ? 167 TRP B O   1 
ATOM   3173 C CB  . TRP B 1 159 ? -1.74026  -9.02004  11.66161 1.000 46.89252  ? 167 TRP B CB  1 
ATOM   3174 C CG  . TRP B 1 159 ? -0.50155  -9.22356  12.43531 1.000 47.30519  ? 167 TRP B CG  1 
ATOM   3175 C CD1 . TRP B 1 159 ? 0.70160   -8.62174  12.21554 1.000 47.99047  ? 167 TRP B CD1 1 
ATOM   3176 C CD2 . TRP B 1 159 ? -0.32106  -10.08436 13.56809 1.000 46.25305  ? 167 TRP B CD2 1 
ATOM   3177 N NE1 . TRP B 1 159 ? 1.62423   -9.06438  13.12604 1.000 45.77115  ? 167 TRP B NE1 1 
ATOM   3178 C CE2 . TRP B 1 159 ? 1.02458   -9.95694  13.97395 1.000 46.00993  ? 167 TRP B CE2 1 
ATOM   3179 C CE3 . TRP B 1 159 ? -1.16171  -10.94895 14.27443 1.000 39.43247  ? 167 TRP B CE3 1 
ATOM   3180 C CZ2 . TRP B 1 159 ? 1.55133   -10.66300 15.05620 1.000 46.56656  ? 167 TRP B CZ2 1 
ATOM   3181 C CZ3 . TRP B 1 159 ? -0.64664  -11.64701 15.34356 1.000 40.71552  ? 167 TRP B CZ3 1 
ATOM   3182 C CH2 . TRP B 1 159 ? 0.70261   -11.50375 15.72739 1.000 49.25011  ? 167 TRP B CH2 1 
ATOM   3183 N N   . HIS B 1 160 ? -3.74636  -10.79436 9.08938  1.000 51.78233  ? 168 HIS B N   1 
ATOM   3184 C CA  . HIS B 1 160 ? -5.10391  -11.11851 8.66973  1.000 53.04705  ? 168 HIS B CA  1 
ATOM   3185 C C   . HIS B 1 160 ? -5.46468  -12.47312 9.25905  1.000 53.76296  ? 168 HIS B C   1 
ATOM   3186 O O   . HIS B 1 160 ? -4.68260  -13.42838 9.15704  1.000 44.50379  ? 168 HIS B O   1 
ATOM   3187 C CB  . HIS B 1 160 ? -5.23698  -11.18562 7.14512  1.000 57.46261  ? 168 HIS B CB  1 
ATOM   3188 C CG  . HIS B 1 160 ? -4.86328  -9.92416  6.43312  1.000 62.56797  ? 168 HIS B CG  1 
ATOM   3189 N ND1 . HIS B 1 160 ? -4.64899  -9.88090  5.07133  1.000 65.38621  ? 168 HIS B ND1 1 
ATOM   3190 C CD2 . HIS B 1 160 ? -4.65036  -8.66437  6.88794  1.000 64.57939  ? 168 HIS B CD2 1 
ATOM   3191 C CE1 . HIS B 1 160 ? -4.32767  -8.64787  4.71719  1.000 68.35917  ? 168 HIS B CE1 1 
ATOM   3192 N NE2 . HIS B 1 160 ? -4.31484  -7.89148  5.80114  1.000 66.01375  ? 168 HIS B NE2 1 
ATOM   3193 N N   . GLY B 1 161 ? -6.66219  -12.56147 9.83340  1.000 52.85582  ? 169 GLY B N   1 
ATOM   3194 C CA  . GLY B 1 161 ? -7.17784  -13.81395 10.34320 1.000 53.39780  ? 169 GLY B CA  1 
ATOM   3195 C C   . GLY B 1 161 ? -7.79178  -14.67327 9.25560  1.000 58.64114  ? 169 GLY B C   1 
ATOM   3196 O O   . GLY B 1 161 ? -8.65276  -14.21887 8.50139  1.000 65.69831  ? 169 GLY B O   1 
ATOM   3197 N N   . GLU B 1 162 ? -7.31703  -15.90002 9.12988  1.000 54.96754  ? 170 GLU B N   1 
ATOM   3198 C CA  . GLU B 1 162 ? -7.82852  -16.84637 8.15476  1.000 60.09848  ? 170 GLU B CA  1 
ATOM   3199 C C   . GLU B 1 162 ? -8.68588  -17.87932 8.88070  1.000 57.31411  ? 170 GLU B C   1 
ATOM   3200 O O   . GLU B 1 162 ? -8.23245  -18.47432 9.86476  1.000 54.68798  ? 170 GLU B O   1 
ATOM   3201 C CB  . GLU B 1 162 ? -6.65156  -17.50143 7.43234  1.000 62.68986  ? 170 GLU B CB  1 
ATOM   3202 C CG  . GLU B 1 162 ? -6.99514  -18.27183 6.18655  1.000 71.37949  ? 170 GLU B CG  1 
ATOM   3203 C CD  . GLU B 1 162 ? -5.75043  -18.59151 5.37163  1.000 80.86067  ? 170 GLU B CD  1 
ATOM   3204 O OE1 . GLU B 1 162 ? -5.45880  -19.79791 5.18105  1.000 75.73365  ? 170 GLU B OE1 1 
ATOM   3205 O OE2 . GLU B 1 162 ? -5.06904  -17.63202 4.92207  1.000 79.15059  ? 170 GLU B OE2 1 
ATOM   3206 N N   . VAL B 1 163 ? -9.92050  -18.08288 8.41641  1.000 57.52071  ? 171 VAL B N   1 
ATOM   3207 C CA  . VAL B 1 163 ? -10.78042 -19.10519 9.01392  1.000 54.87870  ? 171 VAL B CA  1 
ATOM   3208 C C   . VAL B 1 163 ? -10.20988 -20.48473 8.72772  1.000 56.50441  ? 171 VAL B C   1 
ATOM   3209 O O   . VAL B 1 163 ? -10.06183 -20.88599 7.56697  1.000 60.18023  ? 171 VAL B O   1 
ATOM   3210 C CB  . VAL B 1 163 ? -12.22109 -19.00983 8.50555  1.000 62.14113  ? 171 VAL B CB  1 
ATOM   3211 C CG1 . VAL B 1 163 ? -13.06309 -20.07007 9.21040  1.000 58.00379  ? 171 VAL B CG1 1 
ATOM   3212 C CG2 . VAL B 1 163 ? -12.78558 -17.62272 8.76950  1.000 68.40932  ? 171 VAL B CG2 1 
ATOM   3213 N N   . LEU B 1 164 ? -9.94828  -21.23824 9.79150  1.000 52.48621  ? 172 LEU B N   1 
ATOM   3214 C CA  . LEU B 1 164 ? -9.26086  -22.51345 9.70954  1.000 50.84084  ? 172 LEU B CA  1 
ATOM   3215 C C   . LEU B 1 164 ? -10.09733 -23.69643 10.17855 1.000 51.04687  ? 172 LEU B C   1 
ATOM   3216 O O   . LEU B 1 164 ? -9.77894  -24.83294 9.82247  1.000 50.15378  ? 172 LEU B O   1 
ATOM   3217 C CB  . LEU B 1 164 ? -7.95585  -22.43571 10.52123 1.000 47.94480  ? 172 LEU B CB  1 
ATOM   3218 C CG  . LEU B 1 164 ? -7.22463  -23.66849 11.02281 1.000 51.46925  ? 172 LEU B CG  1 
ATOM   3219 C CD1 . LEU B 1 164 ? -6.46493  -24.30360 9.87117  1.000 52.81729  ? 172 LEU B CD1 1 
ATOM   3220 C CD2 . LEU B 1 164 ? -6.26875  -23.26356 12.15782 1.000 48.53029  ? 172 LEU B CD2 1 
ATOM   3221 N N   . ALA B 1 165 ? -11.15688 -23.46428 10.94356 1.000 45.42788  ? 173 ALA B N   1 
ATOM   3222 C CA  . ALA B 1 165 ? -12.03416 -24.52473 11.39586 1.000 41.42799  ? 173 ALA B CA  1 
ATOM   3223 C C   . ALA B 1 165 ? -13.30992 -23.87287 11.90056 1.000 44.43769  ? 173 ALA B C   1 
ATOM   3224 O O   . ALA B 1 165 ? -13.29939 -22.73445 12.37341 1.000 46.23603  ? 173 ALA B O   1 
ATOM   3225 C CB  . ALA B 1 165 ? -11.38730 -25.36733 12.49711 1.000 38.76369  ? 173 ALA B CB  1 
ATOM   3226 N N   . GLU B 1 166 ? -14.39954 -24.61312 11.81995 1.000 48.09805  ? 174 GLU B N   1 
ATOM   3227 C CA  . GLU B 1 166 ? -15.70306 -24.11076 12.22133 1.000 45.98390  ? 174 GLU B CA  1 
ATOM   3228 C C   . GLU B 1 166 ? -16.47245 -25.24484 12.88370 1.000 45.61291  ? 174 GLU B C   1 
ATOM   3229 O O   . GLU B 1 166 ? -16.44572 -26.38673 12.41214 1.000 46.34495  ? 174 GLU B O   1 
ATOM   3230 C CB  . GLU B 1 166 ? -16.46666 -23.56683 11.00431 1.000 48.75443  ? 174 GLU B CB  1 
ATOM   3231 C CG  . GLU B 1 166 ? -17.93385 -23.29726 11.25155 1.000 57.02487  ? 174 GLU B CG  1 
ATOM   3232 C CD  . GLU B 1 166 ? -18.46347 -22.16006 10.40135 1.000 67.93479  ? 174 GLU B CD  1 
ATOM   3233 O OE1 . GLU B 1 166 ? -17.87659 -21.92238 9.32237  1.000 76.93474  ? 174 GLU B OE1 1 
ATOM   3234 O OE2 . GLU B 1 166 ? -19.42217 -21.47274 10.83365 1.000 67.74086  ? 174 GLU B OE2 1 
ATOM   3235 N N   . SER B 1 167 ? -17.10008 -24.94244 14.01247 1.000 43.10993  ? 175 SER B N   1 
ATOM   3236 C CA  . SER B 1 167 ? -18.06080 -25.83529 14.63383 1.000 42.05832  ? 175 SER B CA  1 
ATOM   3237 C C   . SER B 1 167 ? -19.32867 -25.03317 14.84893 1.000 45.46277  ? 175 SER B C   1 
ATOM   3238 O O   . SER B 1 167 ? -19.26217 -23.89533 15.33031 1.000 41.85948  ? 175 SER B O   1 
ATOM   3239 C CB  . SER B 1 167 ? -17.53964 -26.39734 15.96014 1.000 39.54673  ? 175 SER B CB  1 
ATOM   3240 O OG  . SER B 1 167 ? -18.34545 -27.46926 16.44208 1.000 36.69529  ? 175 SER B OG  1 
ATOM   3241 N N   . LYS B 1 168 ? -20.47170 -25.60828 14.47080 1.000 47.19525  ? 176 LYS B N   1 
ATOM   3242 C CA  . LYS B 1 168 ? -21.73424 -24.88796 14.57893 1.000 49.28193  ? 176 LYS B CA  1 
ATOM   3243 C C   . LYS B 1 168 ? -22.90355 -25.85759 14.50956 1.000 52.22984  ? 176 LYS B C   1 
ATOM   3244 O O   . LYS B 1 168 ? -22.80476 -26.93656 13.92696 1.000 52.39263  ? 176 LYS B O   1 
ATOM   3245 C CB  . LYS B 1 168 ? -21.87496 -23.74990 13.53653 1.000 51.92946  ? 176 LYS B CB  1 
ATOM   3246 C CG  . LYS B 1 168 ? -21.79544 -24.01185 12.02715 1.000 58.74082  ? 176 LYS B CG  1 
ATOM   3247 C CD  . LYS B 1 168 ? -22.96622 -24.76837 11.43828 1.000 66.85319  ? 176 LYS B CD  1 
ATOM   3248 C CE  . LYS B 1 168 ? -22.82559 -24.86372 9.91091  1.000 71.06567  ? 176 LYS B CE  1 
ATOM   3249 N NZ  . LYS B 1 168 ? -24.05092 -25.42411 9.25233  1.000 73.12022  ? 176 LYS B NZ  1 
ATOM   3250 N N   . ARG B 1 169 ? -24.00480 -25.44921 15.13676 1.000 53.21797  ? 177 ARG B N   1 
ATOM   3251 C CA  . ARG B 1 169 ? -25.25786 -26.20361 15.14077 1.000 64.17004  ? 177 ARG B CA  1 
ATOM   3252 C C   . ARG B 1 169 ? -25.86291 -26.34023 13.74016 1.000 66.65063  ? 177 ARG B C   1 
ATOM   3253 O O   . ARG B 1 169 ? -25.54091 -25.60446 12.80271 1.000 67.16984  ? 177 ARG B O   1 
ATOM   3254 C CB  . ARG B 1 169 ? -26.29959 -25.53088 16.02771 1.000 60.88076  ? 177 ARG B CB  1 
ATOM   3255 C CG  . ARG B 1 169 ? -26.39254 -26.03064 17.45322 1.000 58.21982  ? 177 ARG B CG  1 
ATOM   3256 C CD  . ARG B 1 169 ? -27.77979 -25.69675 18.06224 1.000 67.08592  ? 177 ARG B CD  1 
ATOM   3257 N NE  . ARG B 1 169 ? -28.26439 -24.34887 17.76359 1.000 66.14214  ? 177 ARG B NE  1 
ATOM   3258 C CZ  . ARG B 1 169 ? -29.09201 -24.03970 16.77264 1.000 70.41024  ? 177 ARG B CZ  1 
ATOM   3259 N NH1 . ARG B 1 169 ? -29.53855 -24.96086 15.93157 1.000 74.09825  ? 177 ARG B NH1 1 
ATOM   3260 N NH2 . ARG B 1 169 ? -29.47227 -22.77261 16.61504 1.000 66.28301  ? 177 ARG B NH2 1 
ATOM   3261 N N   . GLY B 1 170 ? -26.76219 -27.31247 13.61732 1.000 73.68736  ? 178 GLY B N   1 
ATOM   3262 C CA  . GLY B 1 170 ? -27.47228 -27.50074 12.36410 1.000 77.70490  ? 178 GLY B CA  1 
ATOM   3263 C C   . GLY B 1 170 ? -28.33437 -26.29876 12.02021 1.000 79.76468  ? 178 GLY B C   1 
ATOM   3264 O O   . GLY B 1 170 ? -28.98969 -25.71262 12.88397 1.000 76.26114  ? 178 GLY B O   1 
ATOM   3265 N N   . GLY B 1 171 ? -28.29884 -25.91381 10.74208 1.000 86.21798  ? 179 GLY B N   1 
ATOM   3266 C CA  . GLY B 1 171 ? -29.14790 -24.86504 10.20435 1.000 86.64143  ? 179 GLY B CA  1 
ATOM   3267 C C   . GLY B 1 171 ? -28.90298 -23.51403 10.83631 1.000 92.14038  ? 179 GLY B C   1 
ATOM   3268 O O   . GLY B 1 171 ? -29.44462 -23.22703 11.90953 1.000 91.70206  ? 179 GLY B O   1 
ATOM   3269 N N   . MET B 1 172 ? -28.11803 -22.65964 10.17858 1.000 99.12213  ? 180 MET B N   1 
ATOM   3270 C CA  . MET B 1 172 ? -27.56258 -21.48629 10.83726 1.000 104.69551 ? 180 MET B CA  1 
ATOM   3271 C C   . MET B 1 172 ? -28.05808 -20.18928 10.20659 1.000 108.58877 ? 180 MET B C   1 
ATOM   3272 O O   . MET B 1 172 ? -28.30294 -20.10753 8.99583  1.000 108.77346 ? 180 MET B O   1 
ATOM   3273 C CB  . MET B 1 172 ? -26.01907 -21.50188 10.81638 1.000 100.14614 ? 180 MET B CB  1 
ATOM   3274 C CG  . MET B 1 172 ? -25.42579 -21.15728 12.17328 1.000 96.38711  ? 180 MET B CG  1 
ATOM   3275 S SD  . MET B 1 172 ? -26.09317 -22.30125 13.39919 1.000 96.15370  ? 180 MET B SD  1 
ATOM   3276 C CE  . MET B 1 172 ? -26.90808 -21.19945 14.56231 1.000 76.57643  ? 180 MET B CE  1 
ATOM   3277 N N   . ASP B 1 173 ? -28.20920 -19.17695 11.06838 1.000 108.03671 ? 181 ASP B N   1 
ATOM   3278 C CA  . ASP B 1 173 ? -28.44881 -17.80446 10.63719 1.000 108.86877 ? 181 ASP B CA  1 
ATOM   3279 C C   . ASP B 1 173 ? -27.15005 -17.18373 10.12990 1.000 108.55068 ? 181 ASP B C   1 
ATOM   3280 O O   . ASP B 1 173 ? -27.09419 -16.66351 9.00937  1.000 110.62362 ? 181 ASP B O   1 
ATOM   3281 C CB  . ASP B 1 173 ? -29.04753 -17.00706 11.80326 1.000 101.27750 ? 181 ASP B CB  1 
ATOM   3282 C CG  . ASP B 1 173 ? -29.45332 -15.59582 11.42047 1.000 105.81967 ? 181 ASP B CG  1 
ATOM   3283 O OD1 . ASP B 1 173 ? -28.68799 -14.89671 10.72131 1.000 109.31214 ? 181 ASP B OD1 1 
ATOM   3284 O OD2 . ASP B 1 173 ? -30.55288 -15.17901 11.84149 1.000 106.37181 ? 181 ASP B OD2 1 
ATOM   3285 N N   . GLY B 1 174 ? -26.10440 -17.21636 10.95531 1.000 102.79355 ? 182 GLY B N   1 
ATOM   3286 C CA  . GLY B 1 174 ? -24.77265 -16.81336 10.55115 1.000 102.33673 ? 182 GLY B CA  1 
ATOM   3287 C C   . GLY B 1 174 ? -24.06292 -17.93138 9.80995  1.000 105.16405 ? 182 GLY B C   1 
ATOM   3288 O O   . GLY B 1 174 ? -22.90881 -18.23939 10.12164 1.000 101.54242 ? 182 GLY B O   1 
ATOM   3289 N N   . PHE B 1 175 ? -24.76055 -18.57120 8.86326  1.000 107.92110 ? 183 PHE B N   1 
ATOM   3290 C CA  . PHE B 1 175 ? -24.20584 -19.68568 8.09493  1.000 109.42611 ? 183 PHE B CA  1 
ATOM   3291 C C   . PHE B 1 175 ? -22.82180 -19.36685 7.53840  1.000 110.06107 ? 183 PHE B C   1 
ATOM   3292 O O   . PHE B 1 175 ? -22.58339 -18.27923 7.00409  1.000 109.02957 ? 183 PHE B O   1 
ATOM   3293 C CB  . PHE B 1 175 ? -25.14866 -20.07238 6.94838  1.000 113.82291 ? 183 PHE B CB  1 
ATOM   3294 C CG  . PHE B 1 175 ? -25.59851 -18.90815 6.09471  1.000 116.96537 ? 183 PHE B CG  1 
ATOM   3295 C CD1 . PHE B 1 175 ? -24.78854 -18.42141 5.07334  1.000 118.00270 ? 183 PHE B CD1 1 
ATOM   3296 C CD2 . PHE B 1 175 ? -26.84357 -18.32428 6.29302  1.000 115.38862 ? 183 PHE B CD2 1 
ATOM   3297 C CE1 . PHE B 1 175 ? -25.19656 -17.36148 4.28728  1.000 121.10529 ? 183 PHE B CE1 1 
ATOM   3298 C CE2 . PHE B 1 175 ? -27.26295 -17.26599 5.50483  1.000 118.61908 ? 183 PHE B CE2 1 
ATOM   3299 C CZ  . PHE B 1 175 ? -26.43745 -16.78350 4.50041  1.000 123.21513 ? 183 PHE B CZ  1 
ATOM   3300 N N   . LEU B 1 176 ? -21.92035 -20.34935 7.66817  1.000 105.30718 ? 184 LEU B N   1 
ATOM   3301 C CA  . LEU B 1 176 ? -20.57245 -20.37676 7.10133  1.000 102.06144 ? 184 LEU B CA  1 
ATOM   3302 C C   . LEU B 1 176 ? -19.98558 -18.98366 6.89905  1.000 101.02074 ? 184 LEU B C   1 
ATOM   3303 O O   . LEU B 1 176 ? -20.04760 -18.42420 5.79683  1.000 103.39054 ? 184 LEU B O   1 
ATOM   3304 C CB  . LEU B 1 176 ? -20.58240 -21.14178 5.77121  1.000 104.88279 ? 184 LEU B CB  1 
ATOM   3305 C CG  . LEU B 1 176 ? -20.71970 -22.66885 5.85197  1.000 105.62810 ? 184 LEU B CG  1 
ATOM   3306 C CD1 . LEU B 1 176 ? -20.77864 -23.29648 4.46390  1.000 107.61018 ? 184 LEU B CD1 1 
ATOM   3307 C CD2 . LEU B 1 176 ? -19.58469 -23.27641 6.66515  1.000 98.27750  ? 184 LEU B CD2 1 
ATOM   3308 N N   . GLY B 1 177 ? -19.41071 -18.42051 7.96071  1.000 96.80546  ? 185 GLY B N   1 
ATOM   3309 C CA  . GLY B 1 177 ? -18.81753 -17.09941 7.89131  1.000 95.75584  ? 185 GLY B CA  1 
ATOM   3310 C C   . GLY B 1 177 ? -17.34113 -17.11097 7.57019  1.000 92.91381  ? 185 GLY B C   1 
ATOM   3311 O O   . GLY B 1 177 ? -16.56779 -16.39699 8.21369  1.000 92.73005  ? 185 GLY B O   1 
ATOM   3312 N N   . MET B 1 178 ? -16.91829 -17.87875 6.56835  1.000 91.36057  ? 186 MET B N   1 
ATOM   3313 C CA  . MET B 1 178 ? -15.48328 -18.05816 6.35945  1.000 89.30386  ? 186 MET B CA  1 
ATOM   3314 C C   . MET B 1 178 ? -14.85232 -16.86389 5.61550  1.000 92.10531  ? 186 MET B C   1 
ATOM   3315 O O   . MET B 1 178 ? -13.74786 -16.96197 5.05215  1.000 89.70760  ? 186 MET B O   1 
ATOM   3316 C CB  . MET B 1 178 ? -15.26025 -19.42009 5.67159  1.000 85.09250  ? 186 MET B CB  1 
ATOM   3317 C CG  . MET B 1 178 ? -13.82974 -19.86775 5.35522  1.000 84.28360  ? 186 MET B CG  1 
ATOM   3318 S SD  . MET B 1 178 ? -13.85035 -21.65369 4.99604  1.000 92.91491  ? 186 MET B SD  1 
ATOM   3319 C CE  . MET B 1 178 ? -14.65621 -22.28489 6.47923  1.000 80.07325  ? 186 MET B CE  1 
ATOM   3320 N N   . HIS B 1 179 ? -15.55245 -15.73081 5.62505  1.000 94.10683  ? 187 HIS B N   1 
ATOM   3321 C CA  . HIS B 1 179 ? -14.97517 -14.48178 5.15217  1.000 94.19267  ? 187 HIS B CA  1 
ATOM   3322 C C   . HIS B 1 179 ? -13.87324 -14.05300 6.12043  1.000 89.55468  ? 187 HIS B C   1 
ATOM   3323 O O   . HIS B 1 179 ? -14.07818 -14.03660 7.34092  1.000 88.56173  ? 187 HIS B O   1 
ATOM   3324 C CB  . HIS B 1 179 ? -16.07398 -13.42297 5.05875  1.000 95.85241  ? 187 HIS B CB  1 
ATOM   3325 C CG  . HIS B 1 179 ? -17.02187 -13.65612 3.92199  1.000 104.07778 ? 187 HIS B CG  1 
ATOM   3326 N ND1 . HIS B 1 179 ? -17.79653 -12.65634 3.37512  1.000 108.77006 ? 187 HIS B ND1 1 
ATOM   3327 C CD2 . HIS B 1 179 ? -17.33119 -14.78660 3.23958  1.000 104.20903 ? 187 HIS B CD2 1 
ATOM   3328 C CE1 . HIS B 1 179 ? -18.53779 -13.15713 2.40192  1.000 107.58095 ? 187 HIS B CE1 1 
ATOM   3329 N NE2 . HIS B 1 179 ? -18.27406 -14.44769 2.29871  1.000 105.72076 ? 187 HIS B NE2 1 
ATOM   3330 N N   . PHE B 1 180 ? -12.69724 -13.70081 5.57249  1.000 87.98652  ? 188 PHE B N   1 
ATOM   3331 C CA  . PHE B 1 180 ? -11.51957 -13.38076 6.38410  1.000 83.13227  ? 188 PHE B CA  1 
ATOM   3332 C C   . PHE B 1 180 ? -11.63049 -11.98649 7.01637  1.000 82.89054  ? 188 PHE B C   1 
ATOM   3333 O O   . PHE B 1 180 ? -12.11755 -11.04550 6.37803  1.000 85.36295  ? 188 PHE B O   1 
ATOM   3334 C CB  . PHE B 1 180 ? -10.24396 -13.48003 5.53640  1.000 78.00611  ? 188 PHE B CB  1 
ATOM   3335 C CG  . PHE B 1 180 ? -9.95264  -14.88235 5.01684  1.000 82.11282  ? 188 PHE B CG  1 
ATOM   3336 C CD1 . PHE B 1 180 ? -10.73688 -15.97400 5.40416  1.000 79.03219  ? 188 PHE B CD1 1 
ATOM   3337 C CD2 . PHE B 1 180 ? -8.88429  -15.10923 4.14985  1.000 82.04247  ? 188 PHE B CD2 1 
ATOM   3338 C CE1 . PHE B 1 180 ? -10.46739 -17.25917 4.93481  1.000 76.60151  ? 188 PHE B CE1 1 
ATOM   3339 C CE2 . PHE B 1 180 ? -8.60821  -16.39541 3.67327  1.000 80.36503  ? 188 PHE B CE2 1 
ATOM   3340 C CZ  . PHE B 1 180 ? -9.40506  -17.47103 4.06543  1.000 77.84649  ? 188 PHE B CZ  1 
ATOM   3341 N N   . PRO B 1 181 ? -11.20034 -11.82961 8.28847  1.000 78.16622  ? 189 PRO B N   1 
ATOM   3342 C CA  . PRO B 1 181 ? -10.94590 -10.48399 8.83175  1.000 72.32092  ? 189 PRO B CA  1 
ATOM   3343 C C   . PRO B 1 181 ? -9.60378  -9.89149  8.41597  1.000 69.94635  ? 189 PRO B C   1 
ATOM   3344 O O   . PRO B 1 181 ? -8.62085  -10.01107 9.15696  1.000 62.13308  ? 189 PRO B O   1 
ATOM   3345 C CB  . PRO B 1 181 ? -10.98697 -10.70813 10.34983 1.000 64.33475  ? 189 PRO B CB  1 
ATOM   3346 C CG  . PRO B 1 181 ? -10.58218 -12.13148 10.52804 1.000 65.87352  ? 189 PRO B CG  1 
ATOM   3347 C CD  . PRO B 1 181 ? -11.17196 -12.86174 9.33996  1.000 72.00002  ? 189 PRO B CD  1 
ATOM   3348 N N   . ALA B 1 182 ? -9.56895  -9.18652  7.28137  1.000 73.69789  ? 190 ALA B N   1 
ATOM   3349 C CA  . ALA B 1 182 ? -8.31477  -8.80253  6.64595  1.000 69.86859  ? 190 ALA B CA  1 
ATOM   3350 C C   . ALA B 1 182 ? -7.86028  -7.43058  7.13483  1.000 73.38505  ? 190 ALA B C   1 
ATOM   3351 O O   . ALA B 1 182 ? -7.37722  -7.30309  8.26747  1.000 69.53870  ? 190 ALA B O   1 
ATOM   3352 C CB  . ALA B 1 182 ? -8.46542  -8.81774  5.12721  1.000 71.65799  ? 190 ALA B CB  1 
ATOM   3353 N N   . THR B 1 183 ? -8.03162  -6.38985  6.30873  1.000 79.88894  ? 191 THR B N   1 
ATOM   3354 C CA  . THR B 1 183 ? -7.76728  -5.02509  6.76496  1.000 79.33840  ? 191 THR B CA  1 
ATOM   3355 C C   . THR B 1 183 ? -8.78684  -4.71730  7.85561  1.000 79.71579  ? 191 THR B C   1 
ATOM   3356 O O   . THR B 1 183 ? -9.75909  -3.97734  7.65346  1.000 73.14370  ? 191 THR B O   1 
ATOM   3357 C CB  . THR B 1 183 ? -7.85821  -4.01386  5.61364  1.000 81.93354  ? 191 THR B CB  1 
ATOM   3358 O OG1 . THR B 1 183 ? -9.01778  -4.29597  4.80744  1.000 83.39407  ? 191 THR B OG1 1 
ATOM   3359 C CG2 . THR B 1 183 ? -6.59941  -4.05060  4.74359  1.000 80.59428  ? 191 THR B CG2 1 
ATOM   3360 N N   . ASP B 1 184 ? -8.55927  -5.32199  9.01956  1.000 72.96464  ? 192 ASP B N   1 
ATOM   3361 C CA  . ASP B 1 184 ? -9.64075  -5.58340  9.94566  1.000 62.88849  ? 192 ASP B CA  1 
ATOM   3362 C C   . ASP B 1 184 ? -9.22214  -5.30692  11.37444 1.000 55.31272  ? 192 ASP B C   1 
ATOM   3363 O O   . ASP B 1 184 ? -9.38032  -4.18750  11.87169 1.000 54.77623  ? 192 ASP B O   1 
ATOM   3364 C CB  . ASP B 1 184 ? -10.09214 -7.03503  9.79039  1.000 63.84944  ? 192 ASP B CB  1 
ATOM   3365 C CG  . ASP B 1 184 ? -11.57758 -7.23344  10.05095 1.000 62.80087  ? 192 ASP B CG  1 
ATOM   3366 O OD1 . ASP B 1 184 ? -12.00980 -7.06262  11.21258 1.000 55.31156  ? 192 ASP B OD1 1 
ATOM   3367 O OD2 . ASP B 1 184 ? -12.30872 -7.57614  9.09138  1.000 69.76768  ? 192 ASP B OD2 1 
ATOM   3368 N N   . ILE B 1 185 ? -8.69195  -6.32609  12.04001 1.000 49.15897  ? 193 ILE B N   1 
ATOM   3369 C CA  . ILE B 1 185 ? -8.58450  -6.26115  13.49031 1.000 47.52766  ? 193 ILE B CA  1 
ATOM   3370 C C   . ILE B 1 185 ? -7.41913  -5.34621  13.83465 1.000 47.57223  ? 193 ILE B C   1 
ATOM   3371 O O   . ILE B 1 185 ? -6.26020  -5.70931  13.59882 1.000 47.41964  ? 193 ILE B O   1 
ATOM   3372 C CB  . ILE B 1 185 ? -8.44503  -7.66218  14.10420 1.000 44.38992  ? 193 ILE B CB  1 
ATOM   3373 C CG1 . ILE B 1 185 ? -9.63294  -8.53611  13.67298 1.000 48.27711  ? 193 ILE B CG1 1 
ATOM   3374 C CG2 . ILE B 1 185 ? -8.39267  -7.56551  15.61149 1.000 40.47268  ? 193 ILE B CG2 1 
ATOM   3375 C CD1 . ILE B 1 185 ? -9.63799  -9.94197  14.27405 1.000 37.57545  ? 193 ILE B CD1 1 
ATOM   3376 N N   . PRO B 1 186 ? -7.68273  -4.16561  14.39484 1.000 46.21732  ? 194 PRO B N   1 
ATOM   3377 C CA  . PRO B 1 186 ? -6.60915  -3.19196  14.63719 1.000 45.17366  ? 194 PRO B CA  1 
ATOM   3378 C C   . PRO B 1 186 ? -5.60280  -3.68702  15.66583 1.000 42.90374  ? 194 PRO B C   1 
ATOM   3379 O O   . PRO B 1 186 ? -5.85954  -4.61338  16.43626 1.000 42.33661  ? 194 PRO B O   1 
ATOM   3380 C CB  . PRO B 1 186 ? -7.35838  -1.95994  15.15120 1.000 48.13975  ? 194 PRO B CB  1 
ATOM   3381 C CG  . PRO B 1 186 ? -8.61602  -2.52765  15.78347 1.000 48.87034  ? 194 PRO B CG  1 
ATOM   3382 C CD  . PRO B 1 186 ? -8.98553  -3.71548  14.92522 1.000 47.32176  ? 194 PRO B CD  1 
ATOM   3383 N N   . VAL B 1 187 ? -4.42718  -3.05089  15.65835 1.000 48.62848  ? 195 VAL B N   1 
ATOM   3384 C CA  . VAL B 1 187 ? -3.34631  -3.48403  16.53866 1.000 43.38979  ? 195 VAL B CA  1 
ATOM   3385 C C   . VAL B 1 187 ? -3.78259  -3.41524  17.99843 1.000 39.91978  ? 195 VAL B C   1 
ATOM   3386 O O   . VAL B 1 187 ? -3.44519  -4.29100  18.79906 1.000 41.37849  ? 195 VAL B O   1 
ATOM   3387 C CB  . VAL B 1 187 ? -2.06076  -2.66251  16.28510 1.000 45.62337  ? 195 VAL B CB  1 
ATOM   3388 C CG1 . VAL B 1 187 ? -1.59431  -2.83701  14.87300 1.000 45.48707  ? 195 VAL B CG1 1 
ATOM   3389 C CG2 . VAL B 1 187 ? -2.27448  -1.19036  16.58702 1.000 43.60119  ? 195 VAL B CG2 1 
ATOM   3390 N N   . GLN B 1 188 ? -4.56167  -2.40364  18.36487 1.000 38.49443  ? 196 GLN B N   1 
ATOM   3391 C CA  . GLN B 1 188 ? -4.93744  -2.25874  19.76553 1.000 40.62411  ? 196 GLN B CA  1 
ATOM   3392 C C   . GLN B 1 188 ? -5.80689  -3.42679  20.21693 1.000 42.22314  ? 196 GLN B C   1 
ATOM   3393 O O   . GLN B 1 188 ? -5.69060  -3.88923  21.35780 1.000 38.42920  ? 196 GLN B O   1 
ATOM   3394 C CB  . GLN B 1 188 ? -5.67823  -0.93729  19.95156 1.000 45.94315  ? 196 GLN B CB  1 
ATOM   3395 C CG  . GLN B 1 188 ? -4.87313  0.30787   19.62302 1.000 49.40600  ? 196 GLN B CG  1 
ATOM   3396 C CD  . GLN B 1 188 ? -4.93966  0.64621   18.12659 1.000 56.95883  ? 196 GLN B CD  1 
ATOM   3397 O OE1 . GLN B 1 188 ? -5.83953  0.18672   17.40426 1.000 50.39883  ? 196 GLN B OE1 1 
ATOM   3398 N NE2 . GLN B 1 188 ? -3.99723  1.47451   17.66459 1.000 57.78475  ? 196 GLN B NE2 1 
ATOM   3399 N N   . ALA B 1 189 ? -6.66546  -3.93002  19.32362 1.000 33.74260  ? 197 ALA B N   1 
ATOM   3400 C CA  . ALA B 1 189 ? -7.47061  -5.10333  19.65368 1.000 37.79893  ? 197 ALA B CA  1 
ATOM   3401 C C   . ALA B 1 189 ? -6.60305  -6.35796  19.75451 1.000 36.46003  ? 197 ALA B C   1 
ATOM   3402 O O   . ALA B 1 189 ? -6.77500  -7.16527  20.67882 1.000 33.23517  ? 197 ALA B O   1 
ATOM   3403 C CB  . ALA B 1 189 ? -8.58543  -5.29438  18.62395 1.000 31.74575  ? 197 ALA B CB  1 
ATOM   3404 N N   . ARG B 1 190 ? -5.65977  -6.53720  18.82209 1.000 37.72430  ? 198 ARG B N   1 
ATOM   3405 C CA  . ARG B 1 190 ? -4.76459  -7.69496  18.90045 1.000 39.37412  ? 198 ARG B CA  1 
ATOM   3406 C C   . ARG B 1 190 ? -3.85739  -7.63270  20.11544 1.000 33.85447  ? 198 ARG B C   1 
ATOM   3407 O O   . ARG B 1 190 ? -3.47942  -8.67457  20.65172 1.000 34.52051  ? 198 ARG B O   1 
ATOM   3408 C CB  . ARG B 1 190 ? -3.94236  -7.83231  17.61579 1.000 35.33694  ? 198 ARG B CB  1 
ATOM   3409 C CG  . ARG B 1 190 ? -4.77829  -8.45621  16.47910 1.000 35.14129  ? 198 ARG B CG  1 
ATOM   3410 C CD  . ARG B 1 190 ? -4.05441  -8.45866  15.13763 1.000 40.55994  ? 198 ARG B CD  1 
ATOM   3411 N NE  . ARG B 1 190 ? -4.04073  -7.14809  14.49027 1.000 46.43370  ? 198 ARG B NE  1 
ATOM   3412 C CZ  . ARG B 1 190 ? -2.94957  -6.44898  14.19704 1.000 46.30764  ? 198 ARG B CZ  1 
ATOM   3413 N NH1 . ARG B 1 190 ? -1.73615  -6.88506  14.50768 1.000 44.00355  ? 198 ARG B NH1 1 
ATOM   3414 N NH2 . ARG B 1 190 ? -3.07720  -5.29054  13.55814 1.000 45.04762  ? 198 ARG B NH2 1 
ATOM   3415 N N   . ALA B 1 191 ? -3.52342  -6.43622  20.58625 1.000 35.84710  ? 199 ALA B N   1 
ATOM   3416 C CA  . ALA B 1 191 ? -2.67574  -6.34046  21.76735 1.000 37.32316  ? 199 ALA B CA  1 
ATOM   3417 C C   . ALA B 1 191 ? -3.42546  -6.80819  23.00486 1.000 40.39110  ? 199 ALA B C   1 
ATOM   3418 O O   . ALA B 1 191 ? -2.83840  -7.42573  23.90691 1.000 38.27906  ? 199 ALA B O   1 
ATOM   3419 C CB  . ALA B 1 191 ? -2.18721  -4.90312  21.95139 1.000 36.06740  ? 199 ALA B CB  1 
ATOM   3420 N N   . LEU B 1 192 ? -4.72215  -6.50494  23.06898 1.000 34.34669  ? 200 LEU B N   1 
ATOM   3421 C CA  . LEU B 1 192 ? -5.53081  -6.94932  24.19365 1.000 35.69347  ? 200 LEU B CA  1 
ATOM   3422 C C   . LEU B 1 192 ? -5.81589  -8.43786  24.11292 1.000 31.99544  ? 200 LEU B C   1 
ATOM   3423 O O   . LEU B 1 192 ? -5.93365  -9.09602  25.15211 1.000 30.81643  ? 200 LEU B O   1 
ATOM   3424 C CB  . LEU B 1 192 ? -6.84375  -6.15950  24.25784 1.000 33.98758  ? 200 LEU B CB  1 
ATOM   3425 C CG  . LEU B 1 192 ? -6.67353  -4.67755  24.58975 1.000 37.43481  ? 200 LEU B CG  1 
ATOM   3426 C CD1 . LEU B 1 192 ? -8.03584  -4.07334  24.98949 1.000 35.79525  ? 200 LEU B CD1 1 
ATOM   3427 C CD2 . LEU B 1 192 ? -5.64971  -4.45032  25.67875 1.000 33.97021  ? 200 LEU B CD2 1 
ATOM   3428 N N   . TYR B 1 193 ? -5.96660  -8.97703  22.89893 1.000 30.19301  ? 201 TYR B N   1 
ATOM   3429 C CA  . TYR B 1 193 ? -6.12761  -10.42310 22.76902 1.000 34.60371  ? 201 TYR B CA  1 
ATOM   3430 C C   . TYR B 1 193 ? -4.87969  -11.15236 23.24244 1.000 36.43479  ? 201 TYR B C   1 
ATOM   3431 O O   . TYR B 1 193 ? -4.96686  -12.27877 23.74936 1.000 30.17258  ? 201 TYR B O   1 
ATOM   3432 C CB  . TYR B 1 193 ? -6.43957  -10.81147 21.32449 1.000 33.69834  ? 201 TYR B CB  1 
ATOM   3433 C CG  . TYR B 1 193 ? -7.82872  -10.49589 20.79862 1.000 37.09278  ? 201 TYR B CG  1 
ATOM   3434 C CD1 . TYR B 1 193 ? -8.96179  -10.80440 21.54302 1.000 39.04521  ? 201 TYR B CD1 1 
ATOM   3435 C CD2 . TYR B 1 193 ? -8.00942  -9.98719  19.51580 1.000 35.56877  ? 201 TYR B CD2 1 
ATOM   3436 C CE1 . TYR B 1 193 ? -10.24838 -10.55734 21.04690 1.000 38.23688  ? 201 TYR B CE1 1 
ATOM   3437 C CE2 . TYR B 1 193 ? -9.27703  -9.73907  19.01107 1.000 38.60140  ? 201 TYR B CE2 1 
ATOM   3438 C CZ  . TYR B 1 193 ? -10.39855 -10.03055 19.77796 1.000 38.80569  ? 201 TYR B CZ  1 
ATOM   3439 O OH  . TYR B 1 193 ? -11.66638 -9.79029  19.28481 1.000 35.97488  ? 201 TYR B OH  1 
ATOM   3440 N N   . THR B 1 194 ? -3.71113  -10.52011 23.07351 1.000 34.35207  ? 202 THR B N   1 
ATOM   3441 C CA  . THR B 1 194 ? -2.45760  -11.09709 23.54243 1.000 34.86536  ? 202 THR B CA  1 
ATOM   3442 C C   . THR B 1 194 ? -2.37963  -11.04427 25.05796 1.000 33.33252  ? 202 THR B C   1 
ATOM   3443 O O   . THR B 1 194 ? -1.94364  -12.00478 25.69917 1.000 35.37793  ? 202 THR B O   1 
ATOM   3444 C CB  . THR B 1 194 ? -1.26994  -10.34618 22.92167 1.000 35.78750  ? 202 THR B CB  1 
ATOM   3445 O OG1 . THR B 1 194 ? -1.40210  -10.34806 21.49288 1.000 34.89273  ? 202 THR B OG1 1 
ATOM   3446 C CG2 . THR B 1 194 ? 0.05618   -11.01598 23.29694 1.000 37.68010  ? 202 THR B CG2 1 
ATOM   3447 N N   . ARG B 1 195 ? -2.82619  -9.94694  25.65386 1.000 31.66063  ? 203 ARG B N   1 
ATOM   3448 C CA  . ARG B 1 195 ? -2.69957  -9.82307  27.10167 1.000 39.30453  ? 203 ARG B CA  1 
ATOM   3449 C C   . ARG B 1 195 ? -3.81430  -10.53390 27.87931 1.000 37.32048  ? 203 ARG B C   1 
ATOM   3450 O O   . ARG B 1 195 ? -3.62246  -10.85514 29.05382 1.000 40.04572  ? 203 ARG B O   1 
ATOM   3451 C CB  . ARG B 1 195 ? -2.65180  -8.33976  27.50068 1.000 39.43005  ? 203 ARG B CB  1 
ATOM   3452 C CG  . ARG B 1 195 ? -1.47722  -7.54091  26.95124 1.000 39.49386  ? 203 ARG B CG  1 
ATOM   3453 C CD  . ARG B 1 195 ? -1.67128  -6.03922  27.18451 1.000 39.02781  ? 203 ARG B CD  1 
ATOM   3454 N NE  . ARG B 1 195 ? -1.64589  -5.66220  28.59697 1.000 39.82009  ? 203 ARG B NE  1 
ATOM   3455 C CZ  . ARG B 1 195 ? -1.76837  -4.41722  29.05310 1.000 44.09390  ? 203 ARG B CZ  1 
ATOM   3456 N NH1 . ARG B 1 195 ? -1.96830  -3.39092  28.23686 1.000 40.77559  ? 203 ARG B NH1 1 
ATOM   3457 N NH2 . ARG B 1 195 ? -1.67546  -4.19243  30.36210 1.000 43.85284  ? 203 ARG B NH2 1 
ATOM   3458 N N   . ASN B 1 196 ? -4.96053  -10.81018 27.27203 1.000 34.32026  ? 204 ASN B N   1 
ATOM   3459 C CA  . ASN B 1 196 ? -6.02791  -11.50324 27.98705 1.000 36.68321  ? 204 ASN B CA  1 
ATOM   3460 C C   . ASN B 1 196 ? -6.40767  -12.78496 27.25042 1.000 34.83893  ? 204 ASN B C   1 
ATOM   3461 O O   . ASN B 1 196 ? -6.73839  -12.72820 26.05565 1.000 34.71671  ? 204 ASN B O   1 
ATOM   3462 C CB  . ASN B 1 196 ? -7.25141  -10.58603 28.14617 1.000 37.27219  ? 204 ASN B CB  1 
ATOM   3463 C CG  . ASN B 1 196 ? -6.89461  -9.22355  28.72431 1.000 39.84628  ? 204 ASN B CG  1 
ATOM   3464 O OD1 . ASN B 1 196 ? -6.73783  -9.07079  29.93327 1.000 43.41296  ? 204 ASN B OD1 1 
ATOM   3465 N ND2 . ASN B 1 196 ? -6.74786  -8.23485  27.86038 1.000 37.72995  ? 204 ASN B ND2 1 
ATOM   3466 N N   . PRO B 1 197 ? -6.37374  -13.95680 27.89706 1.000 34.86844  ? 205 PRO B N   1 
ATOM   3467 C CA  . PRO B 1 197 ? -6.79959  -15.18490 27.20007 1.000 37.63406  ? 205 PRO B CA  1 
ATOM   3468 C C   . PRO B 1 197 ? -8.29224  -15.23830 26.86816 1.000 30.29485  ? 205 PRO B C   1 
ATOM   3469 O O   . PRO B 1 197 ? -8.64568  -15.81598 25.83818 1.000 33.67023  ? 205 PRO B O   1 
ATOM   3470 C CB  . PRO B 1 197 ? -6.41238  -16.30994 28.17589 1.000 37.73129  ? 205 PRO B CB  1 
ATOM   3471 C CG  . PRO B 1 197 ? -5.49684  -15.67677 29.19411 1.000 44.19552  ? 205 PRO B CG  1 
ATOM   3472 C CD  . PRO B 1 197 ? -5.86091  -14.22533 29.25144 1.000 35.94229  ? 205 PRO B CD  1 
ATOM   3473 N N   . LEU B 1 198 ? -9.17497  -14.68077 27.69006 1.000 34.54373  ? 206 LEU B N   1 
ATOM   3474 C CA  . LEU B 1 198 ? -10.62533 -14.76487 27.47162 1.000 34.55259  ? 206 LEU B CA  1 
ATOM   3475 C C   . LEU B 1 198 ? -11.24736 -13.37357 27.37231 1.000 32.72193  ? 206 LEU B C   1 
ATOM   3476 O O   . LEU B 1 198 ? -10.90916 -12.48650 28.16015 1.000 34.52874  ? 206 LEU B O   1 
ATOM   3477 C CB  . LEU B 1 198 ? -11.31699 -15.53397 28.61121 1.000 33.32612  ? 206 LEU B CB  1 
ATOM   3478 C CG  . LEU B 1 198 ? -11.00367 -17.00866 28.88343 1.000 33.79067  ? 206 LEU B CG  1 
ATOM   3479 C CD1 . LEU B 1 198 ? -11.97154 -17.56126 29.91462 1.000 33.42563  ? 206 LEU B CD1 1 
ATOM   3480 C CD2 . LEU B 1 198 ? -11.04453 -17.84643 27.59737 1.000 31.24516  ? 206 LEU B CD2 1 
ATOM   3481 N N   . ARG B 1 199 ? -12.17639 -13.19443 26.42332 1.000 34.17881  ? 207 ARG B N   1 
ATOM   3482 C CA  . ARG B 1 199 ? -12.90897 -11.93574 26.25252 1.000 33.23478  ? 207 ARG B CA  1 
ATOM   3483 C C   . ARG B 1 199 ? -14.39256 -12.23347 26.04345 1.000 33.25315  ? 207 ARG B C   1 
ATOM   3484 O O   . ARG B 1 199 ? -14.75731 -12.92491 25.08763 1.000 31.21121  ? 207 ARG B O   1 
ATOM   3485 C CB  . ARG B 1 199 ? -12.36935 -11.13709 25.06428 1.000 30.84784  ? 207 ARG B CB  1 
ATOM   3486 C CG  . ARG B 1 199 ? -13.24896 -9.94891  24.63843 1.000 38.02318  ? 207 ARG B CG  1 
ATOM   3487 C CD  . ARG B 1 199 ? -13.27230 -8.84650  25.72141 1.000 39.37898  ? 207 ARG B CD  1 
ATOM   3488 N NE  . ARG B 1 199 ? -13.78267 -7.56273  25.24681 1.000 37.44010  ? 207 ARG B NE  1 
ATOM   3489 C CZ  . ARG B 1 199 ? -14.24405 -6.60554  26.04548 1.000 32.20613  ? 207 ARG B CZ  1 
ATOM   3490 N NH1 . ARG B 1 199 ? -14.31842 -6.76952  27.35602 1.000 27.40495  ? 207 ARG B NH1 1 
ATOM   3491 N NH2 . ARG B 1 199 ? -14.65622 -5.46064  25.51417 1.000 34.63080  ? 207 ARG B NH2 1 
ATOM   3492 N N   . LEU B 1 200 ? -15.25857 -11.67520 26.89164 1.000 29.74469  ? 208 LEU B N   1 
ATOM   3493 C CA  . LEU B 1 200 ? -16.69586 -11.92590 26.79171 1.000 32.40022  ? 208 LEU B CA  1 
ATOM   3494 C C   . LEU B 1 200 ? -17.45419 -10.61770 26.56342 1.000 33.66535  ? 208 LEU B C   1 
ATOM   3495 O O   . LEU B 1 200 ? -17.33020 -9.67437  27.35380 1.000 29.87850  ? 208 LEU B O   1 
ATOM   3496 C CB  . LEU B 1 200 ? -17.22839 -12.61538 28.04485 1.000 28.76109  ? 208 LEU B CB  1 
ATOM   3497 C CG  . LEU B 1 200 ? -18.78714 -12.63892 28.13750 1.000 31.61792  ? 208 LEU B CG  1 
ATOM   3498 C CD1 . LEU B 1 200 ? -19.41557 -13.63253 27.16083 1.000 29.35283  ? 208 LEU B CD1 1 
ATOM   3499 C CD2 . LEU B 1 200 ? -19.21962 -12.97630 29.53313 1.000 32.38574  ? 208 LEU B CD2 1 
ATOM   3500 N N   . ILE B 1 201 ? -18.22197 -10.56868 25.47695 1.000 32.27812  ? 209 ILE B N   1 
ATOM   3501 C CA  . ILE B 1 201 ? -19.24463 -9.55189  25.23781 1.000 32.86614  ? 209 ILE B CA  1 
ATOM   3502 C C   . ILE B 1 201 ? -20.58456 -10.22313 25.52182 1.000 31.34456  ? 209 ILE B C   1 
ATOM   3503 O O   . ILE B 1 201 ? -21.04389 -11.04577 24.73336 1.000 28.60385  ? 209 ILE B O   1 
ATOM   3504 C CB  . ILE B 1 201 ? -19.15601 -9.00191  23.80987 1.000 33.00538  ? 209 ILE B CB  1 
ATOM   3505 C CG1 . ILE B 1 201 ? -17.75737 -8.38051  23.59043 1.000 34.04764  ? 209 ILE B CG1 1 
ATOM   3506 C CG2 . ILE B 1 201 ? -20.35892 -8.10614  23.49191 1.000 37.46273  ? 209 ILE B CG2 1 
ATOM   3507 C CD1 . ILE B 1 201 ? -17.39598 -8.10981  22.17314 1.000 32.80577  ? 209 ILE B CD1 1 
ATOM   3508 N N   . ALA B 1 202 ? -21.18694 -9.91995  26.67696 1.000 29.21684  ? 210 ALA B N   1 
ATOM   3509 C CA  . ALA B 1 202 ? -22.37186 -10.66172 27.12776 1.000 32.80867  ? 210 ALA B CA  1 
ATOM   3510 C C   . ALA B 1 202 ? -23.58956 -10.42013 26.22995 1.000 34.04495  ? 210 ALA B C   1 
ATOM   3511 O O   . ALA B 1 202 ? -24.41624 -11.31958 26.04215 1.000 34.52593  ? 210 ALA B O   1 
ATOM   3512 C CB  . ALA B 1 202 ? -22.70861 -10.29754 28.57631 1.000 30.19955  ? 210 ALA B CB  1 
ATOM   3513 N N   . ASP B 1 203 ? -23.74736 -9.21240  25.70118 1.000 31.70475  ? 211 ASP B N   1 
ATOM   3514 C CA  . ASP B 1 203 ? -24.92554 -8.92364  24.88378 1.000 35.88728  ? 211 ASP B CA  1 
ATOM   3515 C C   . ASP B 1 203 ? -24.62705 -7.71745  24.00739 1.000 34.50222  ? 211 ASP B C   1 
ATOM   3516 O O   . ASP B 1 203 ? -24.54936 -6.59279  24.51327 1.000 33.63849  ? 211 ASP B O   1 
ATOM   3517 C CB  . ASP B 1 203 ? -26.14766 -8.68143  25.76518 1.000 34.68691  ? 211 ASP B CB  1 
ATOM   3518 C CG  . ASP B 1 203 ? -27.42657 -8.41630  24.95094 1.000 38.26206  ? 211 ASP B CG  1 
ATOM   3519 O OD1 . ASP B 1 203 ? -27.41709 -8.52097  23.68919 1.000 35.47942  ? 211 ASP B OD1 1 
ATOM   3520 O OD2 . ASP B 1 203 ? -28.46767 -8.21152  25.60387 1.000 37.32196  ? 211 ASP B OD2 1 
ATOM   3521 N N   . ALA B 1 204 ? -24.48129 -7.94529  22.69996 1.000 32.58876  ? 212 ALA B N   1 
ATOM   3522 C CA  . ALA B 1 204 ? -24.16809 -6.83360  21.81263 1.000 37.33704  ? 212 ALA B CA  1 
ATOM   3523 C C   . ALA B 1 204 ? -25.33669 -5.85839  21.67392 1.000 38.59061  ? 212 ALA B C   1 
ATOM   3524 O O   . ALA B 1 204 ? -25.14723 -4.76186  21.13592 1.000 37.69314  ? 212 ALA B O   1 
ATOM   3525 C CB  . ALA B 1 204 ? -23.75053 -7.36042  20.44044 1.000 34.08398  ? 212 ALA B CB  1 
ATOM   3526 N N   . ARG B 1 205 ? -26.53627 -6.21888  22.13794 1.000 33.70472  ? 213 ARG B N   1 
ATOM   3527 C CA  . ARG B 1 205 ? -27.62551 -5.24350  22.14016 1.000 40.57701  ? 213 ARG B CA  1 
ATOM   3528 C C   . ARG B 1 205 ? -27.67787 -4.41586  23.41874 1.000 40.28783  ? 213 ARG B C   1 
ATOM   3529 O O   . ARG B 1 205 ? -28.39773 -3.40677  23.45367 1.000 37.18544  ? 213 ARG B O   1 
ATOM   3530 C CB  . ARG B 1 205 ? -28.98306 -5.92958  21.90971 1.000 36.81744  ? 213 ARG B CB  1 
ATOM   3531 C CG  . ARG B 1 205 ? -29.31315 -6.18518  20.43042 1.000 40.43975  ? 213 ARG B CG  1 
ATOM   3532 C CD  . ARG B 1 205 ? -30.43645 -7.20346  20.23810 1.000 36.54936  ? 213 ARG B CD  1 
ATOM   3533 N NE  . ARG B 1 205 ? -31.52555 -6.95840  21.17695 1.000 43.09645  ? 213 ARG B NE  1 
ATOM   3534 C CZ  . ARG B 1 205 ? -32.69792 -7.58271  21.16236 1.000 44.06155  ? 213 ARG B CZ  1 
ATOM   3535 N NH1 . ARG B 1 205 ? -33.00086 -8.46815  20.22426 1.000 43.28574  ? 213 ARG B NH1 1 
ATOM   3536 N NH2 . ARG B 1 205 ? -33.58557 -7.31451  22.11558 1.000 38.56051  ? 213 ARG B NH2 1 
ATOM   3537 N N   . ALA B 1 206 ? -26.92800 -4.80355  24.45435 1.000 33.06320  ? 214 ALA B N   1 
ATOM   3538 C CA  . ALA B 1 206 ? -26.91777 -4.03124  25.68387 1.000 33.95661  ? 214 ALA B CA  1 
ATOM   3539 C C   . ALA B 1 206 ? -26.16325 -2.71916  25.45266 1.000 34.62707  ? 214 ALA B C   1 
ATOM   3540 O O   . ALA B 1 206 ? -25.50610 -2.53024  24.42602 1.000 33.85343  ? 214 ALA B O   1 
ATOM   3541 C CB  . ALA B 1 206 ? -26.30396 -4.84975  26.82266 1.000 33.51705  ? 214 ALA B CB  1 
ATOM   3542 N N   . ARG B 1 207 ? -26.30921 -1.78310  26.39765 1.000 32.06123  ? 215 ARG B N   1 
ATOM   3543 C CA  . ARG B 1 207 ? -25.76953 -0.42151  26.37108 1.000 36.09442  ? 215 ARG B CA  1 
ATOM   3544 C C   . ARG B 1 207 ? -24.56241 -0.29309  27.29801 1.000 35.55639  ? 215 ARG B C   1 
ATOM   3545 O O   . ARG B 1 207 ? -24.58560 -0.80582  28.42525 1.000 34.69293  ? 215 ARG B O   1 
ATOM   3546 C CB  . ARG B 1 207 ? -26.83398 0.59558   26.79509 1.000 35.95903  ? 215 ARG B CB  1 
ATOM   3547 C CG  . ARG B 1 207 ? -28.17620 0.48269   26.07013 1.000 36.45267  ? 215 ARG B CG  1 
ATOM   3548 C CD  . ARG B 1 207 ? -28.19539 1.36879   24.84280 1.000 41.63717  ? 215 ARG B CD  1 
ATOM   3549 N NE  . ARG B 1 207 ? -29.43976 1.26881   24.07861 1.000 41.64158  ? 215 ARG B NE  1 
ATOM   3550 C CZ  . ARG B 1 207 ? -29.60425 1.81107   22.87854 1.000 37.84738  ? 215 ARG B CZ  1 
ATOM   3551 N NH1 . ARG B 1 207 ? -28.65754 2.55130   22.32020 1.000 36.59145  ? 215 ARG B NH1 1 
ATOM   3552 N NH2 . ARG B 1 207 ? -30.74790 1.62503   22.23453 1.000 40.57853  ? 215 ARG B NH2 1 
ATOM   3553 N N   . PRO B 1 208 ? -23.48580 0.36766   26.87871 1.000 31.68853  ? 216 PRO B N   1 
ATOM   3554 C CA  . PRO B 1 208 ? -22.34587 0.53963   27.78184 1.000 36.11999  ? 216 PRO B CA  1 
ATOM   3555 C C   . PRO B 1 208 ? -22.72366 1.45769   28.92314 1.000 37.20854  ? 216 PRO B C   1 
ATOM   3556 O O   . PRO B 1 208 ? -23.55905 2.34335   28.76948 1.000 40.87952  ? 216 PRO B O   1 
ATOM   3557 C CB  . PRO B 1 208 ? -21.26539 1.17180   26.89371 1.000 36.98428  ? 216 PRO B CB  1 
ATOM   3558 C CG  . PRO B 1 208 ? -22.00205 1.82989   25.79571 1.000 39.67607  ? 216 PRO B CG  1 
ATOM   3559 C CD  . PRO B 1 208 ? -23.23919 0.95371   25.55292 1.000 37.95991  ? 216 PRO B CD  1 
ATOM   3560 N N   . VAL B 1 209 ? -22.10151 1.23365   30.07333 1.000 37.59147  ? 217 VAL B N   1 
ATOM   3561 C CA  . VAL B 1 209 ? -22.31922 2.02886   31.27733 1.000 37.77931  ? 217 VAL B CA  1 
ATOM   3562 C C   . VAL B 1 209 ? -21.07801 2.88448   31.49810 1.000 38.49186  ? 217 VAL B C   1 
ATOM   3563 O O   . VAL B 1 209 ? -19.96764 2.33859   31.58942 1.000 34.18899  ? 217 VAL B O   1 
ATOM   3564 C CB  . VAL B 1 209 ? -22.59394 1.15300   32.50699 1.000 39.20668  ? 217 VAL B CB  1 
ATOM   3565 C CG1 . VAL B 1 209 ? -22.66091 2.04049   33.75451 1.000 35.72853  ? 217 VAL B CG1 1 
ATOM   3566 C CG2 . VAL B 1 209 ? -23.87821 0.35210   32.31664 1.000 34.87518  ? 217 VAL B CG2 1 
ATOM   3567 N N   . PRO B 1 210 ? -21.21758 4.20529   31.60620 1.000 38.40524  ? 218 PRO B N   1 
ATOM   3568 C CA  . PRO B 1 210 ? -20.03803 5.07423   31.76563 1.000 40.88992  ? 218 PRO B CA  1 
ATOM   3569 C C   . PRO B 1 210 ? -19.36795 4.93808   33.12697 1.000 39.64055  ? 218 PRO B C   1 
ATOM   3570 O O   . PRO B 1 210 ? -20.01018 4.69433   34.14924 1.000 38.49711  ? 218 PRO B O   1 
ATOM   3571 C CB  . PRO B 1 210 ? -20.60891 6.48842   31.57249 1.000 38.15923  ? 218 PRO B CB  1 
ATOM   3572 C CG  . PRO B 1 210 ? -22.10897 6.33823   31.78704 1.000 41.43986  ? 218 PRO B CG  1 
ATOM   3573 C CD  . PRO B 1 210 ? -22.45964 4.96396   31.32754 1.000 36.17158  ? 218 PRO B CD  1 
ATOM   3574 N N   . LEU B 1 211 ? -18.04669 5.10346   33.12852 1.000 40.74561  ? 219 LEU B N   1 
ATOM   3575 C CA  . LEU B 1 211 ? -17.27750 5.17463   34.37055 1.000 42.78832  ? 219 LEU B CA  1 
ATOM   3576 C C   . LEU B 1 211 ? -17.20921 6.62343   34.86306 1.000 40.97271  ? 219 LEU B C   1 
ATOM   3577 O O   . LEU B 1 211 ? -17.03912 7.55576   34.07261 1.000 43.95907  ? 219 LEU B O   1 
ATOM   3578 C CB  . LEU B 1 211 ? -15.86676 4.59492   34.16843 1.000 38.98083  ? 219 LEU B CB  1 
ATOM   3579 C CG  . LEU B 1 211 ? -15.78790 3.06924   33.97077 1.000 40.35243  ? 219 LEU B CG  1 
ATOM   3580 C CD1 . LEU B 1 211 ? -14.35261 2.51148   33.72545 1.000 36.57086  ? 219 LEU B CD1 1 
ATOM   3581 C CD2 . LEU B 1 211 ? -16.41413 2.35776   35.13203 1.000 40.81946  ? 219 LEU B CD2 1 
ATOM   3582 N N   . LEU B 1 212 ? -17.33262 6.80590   36.17897 1.000 42.59271  ? 220 LEU B N   1 
ATOM   3583 C CA  . LEU B 1 212 ? -17.34257 8.12261   36.81227 1.000 45.27198  ? 220 LEU B CA  1 
ATOM   3584 C C   . LEU B 1 212 ? -16.13530 8.30238   37.73091 1.000 46.89788  ? 220 LEU B C   1 
ATOM   3585 O O   . LEU B 1 212 ? -15.80542 7.39008   38.50222 1.000 46.35048  ? 220 LEU B O   1 
ATOM   3586 C CB  . LEU B 1 212 ? -18.62890 8.33058   37.63783 1.000 47.45641  ? 220 LEU B CB  1 
ATOM   3587 C CG  . LEU B 1 212 ? -19.95971 8.02895   36.96063 1.000 47.93928  ? 220 LEU B CG  1 
ATOM   3588 C CD1 . LEU B 1 212 ? -21.10371 8.15356   37.95297 1.000 49.14923  ? 220 LEU B CD1 1 
ATOM   3589 C CD2 . LEU B 1 212 ? -20.16505 8.97403   35.81040 1.000 46.97225  ? 220 LEU B CD2 1 
ATOM   3590 N N   . PRO B 1 213 ? -15.45575 9.47742   37.68751 1.000 47.78005  ? 221 PRO B N   1 
ATOM   3591 C CA  . PRO B 1 213 ? -15.68347 10.63893  36.79759 1.000 45.30839  ? 221 PRO B CA  1 
ATOM   3592 C C   . PRO B 1 213 ? -15.22712 10.34789  35.37329 1.000 47.53996  ? 221 PRO B C   1 
ATOM   3593 O O   . PRO B 1 213 ? -14.48686 9.39301   35.17087 1.000 47.76183  ? 221 PRO B O   1 
ATOM   3594 C CB  . PRO B 1 213 ? -14.86282 11.76550  37.46336 1.000 45.93743  ? 221 PRO B CB  1 
ATOM   3595 C CG  . PRO B 1 213 ? -14.60173 11.30215  38.86586 1.000 47.64050  ? 221 PRO B CG  1 
ATOM   3596 C CD  . PRO B 1 213 ? -14.50068 9.80347   38.75802 1.000 45.47800  ? 221 PRO B CD  1 
ATOM   3597 N N   . PRO B 1 214 ? -15.64820 11.13015  34.37076 1.000 49.54162  ? 222 PRO B N   1 
ATOM   3598 C CA  . PRO B 1 214 ? -15.28858 10.79026  32.98301 1.000 48.11829  ? 222 PRO B CA  1 
ATOM   3599 C C   . PRO B 1 214 ? -13.79022 10.68021  32.73428 1.000 50.57853  ? 222 PRO B C   1 
ATOM   3600 O O   . PRO B 1 214 ? -13.36241 9.83683   31.93598 1.000 52.65045  ? 222 PRO B O   1 
ATOM   3601 C CB  . PRO B 1 214 ? -15.92732 11.92880  32.18000 1.000 43.88418  ? 222 PRO B CB  1 
ATOM   3602 C CG  . PRO B 1 214 ? -17.07263 12.36709  33.02365 1.000 44.19504  ? 222 PRO B CG  1 
ATOM   3603 C CD  . PRO B 1 214 ? -16.58470 12.26728  34.42612 1.000 46.78505  ? 222 PRO B CD  1 
ATOM   3604 N N   . VAL B 1 215 ? -12.96871 11.47905  33.39289 1.000 51.00418  ? 223 VAL B N   1 
ATOM   3605 C CA  . VAL B 1 215 ? -11.52544 11.28010  33.35064 1.000 51.00429  ? 223 VAL B CA  1 
ATOM   3606 C C   . VAL B 1 215 ? -11.03465 11.18210  34.78385 1.000 52.85343  ? 223 VAL B C   1 
ATOM   3607 O O   . VAL B 1 215 ? -11.57179 11.84572  35.67768 1.000 54.83381  ? 223 VAL B O   1 
ATOM   3608 C CB  . VAL B 1 215 ? -10.78874 12.40733  32.59207 1.000 53.29885  ? 223 VAL B CB  1 
ATOM   3609 C CG1 . VAL B 1 215 ? -11.19019 12.41060  31.12199 1.000 50.02687  ? 223 VAL B CG1 1 
ATOM   3610 C CG2 . VAL B 1 215 ? -11.04866 13.75835  33.24585 1.000 50.68473  ? 223 VAL B CG2 1 
ATOM   3611 N N   . VAL B 1 216 ? -10.04780 10.32294  35.01264 1.000 48.85645  ? 224 VAL B N   1 
ATOM   3612 C CA  . VAL B 1 216 ? -9.51765  10.14829  36.35847 1.000 53.72247  ? 224 VAL B CA  1 
ATOM   3613 C C   . VAL B 1 216 ? -8.67412  11.37980  36.68367 1.000 57.35143  ? 224 VAL B C   1 
ATOM   3614 O O   . VAL B 1 216 ? -7.72877  11.70623  35.95033 1.000 52.12103  ? 224 VAL B O   1 
ATOM   3615 C CB  . VAL B 1 216 ? -8.73476  8.83191   36.48079 1.000 57.06200  ? 224 VAL B CB  1 
ATOM   3616 C CG1 . VAL B 1 216 ? -8.21092  8.62994   37.90002 1.000 60.65640  ? 224 VAL B CG1 1 
ATOM   3617 C CG2 . VAL B 1 216 ? -9.62106  7.63886   36.06169 1.000 52.34977  ? 224 VAL B CG2 1 
ATOM   3618 N N   . PRO B 1 217 ? -9.00184  12.11200  37.75541 1.000 61.38789  ? 225 PRO B N   1 
ATOM   3619 C CA  . PRO B 1 217 ? -8.30823  13.38945  38.01031 1.000 60.82746  ? 225 PRO B CA  1 
ATOM   3620 C C   . PRO B 1 217 ? -6.79416  13.24724  38.06759 1.000 60.09936  ? 225 PRO B C   1 
ATOM   3621 O O   . PRO B 1 217 ? -6.07021  14.05532  37.47675 1.000 62.38965  ? 225 PRO B O   1 
ATOM   3622 C CB  . PRO B 1 217 ? -8.89974  13.83652  39.35434 1.000 60.08367  ? 225 PRO B CB  1 
ATOM   3623 C CG  . PRO B 1 217 ? -9.33598  12.55736  40.02779 1.000 62.84951  ? 225 PRO B CG  1 
ATOM   3624 C CD  . PRO B 1 217 ? -9.82222  11.68077  38.90413 1.000 63.47448  ? 225 PRO B CD  1 
ATOM   3625 N N   . ALA B 1 218 ? -6.30086  12.22401  38.76035 1.000 56.35193  ? 226 ALA B N   1 
ATOM   3626 C CA  . ALA B 1 218 ? -4.86897  11.99123  38.84041 1.000 55.56510  ? 226 ALA B CA  1 
ATOM   3627 C C   . ALA B 1 218 ? -4.25159  11.65846  37.48764 1.000 55.50645  ? 226 ALA B C   1 
ATOM   3628 O O   . ALA B 1 218 ? -3.02823  11.70614  37.35738 1.000 58.42767  ? 226 ALA B O   1 
ATOM   3629 C CB  . ALA B 1 218 ? -4.58349  10.87306  39.84069 1.000 62.71624  ? 226 ALA B CB  1 
ATOM   3630 N N   . LEU B 1 219 ? -5.05414  11.27969  36.48895 1.000 58.91491  ? 227 LEU B N   1 
ATOM   3631 C CA  . LEU B 1 219 ? -4.51757  10.74922  35.24010 1.000 54.38951  ? 227 LEU B CA  1 
ATOM   3632 C C   . LEU B 1 219 ? -4.74976  11.64249  34.02885 1.000 53.20460  ? 227 LEU B C   1 
ATOM   3633 O O   . LEU B 1 219 ? -4.02223  11.50444  33.03929 1.000 48.61401  ? 227 LEU B O   1 
ATOM   3634 C CB  . LEU B 1 219 ? -5.12597  9.37009   34.92973 1.000 52.69078  ? 227 LEU B CB  1 
ATOM   3635 C CG  . LEU B 1 219 ? -4.96245  8.20485   35.90135 1.000 52.65537  ? 227 LEU B CG  1 
ATOM   3636 C CD1 . LEU B 1 219 ? -5.80039  7.01596   35.44218 1.000 54.23296  ? 227 LEU B CD1 1 
ATOM   3637 C CD2 . LEU B 1 219 ? -3.51657  7.80179   36.03442 1.000 47.02551  ? 227 LEU B CD2 1 
ATOM   3638 N N   . GLY B 1 220 ? -5.75468  12.51866  34.06151 1.000 48.92526  ? 228 GLY B N   1 
ATOM   3639 C CA  . GLY B 1 220 ? -6.09392  13.31106  32.89422 1.000 46.24141  ? 228 GLY B CA  1 
ATOM   3640 C C   . GLY B 1 220 ? -6.73955  12.54125  31.76492 1.000 46.61068  ? 228 GLY B C   1 
ATOM   3641 O O   . GLY B 1 220 ? -6.88664  13.09090  30.66695 1.000 42.68206  ? 228 GLY B O   1 
ATOM   3642 N N   . ARG B 1 221 ? -7.17051  11.30553  32.01630 1.000 47.61104  ? 229 ARG B N   1 
ATOM   3643 C CA  . ARG B 1 221 ? -7.77759  10.43866  31.01177 1.000 46.30318  ? 229 ARG B CA  1 
ATOM   3644 C C   . ARG B 1 221 ? -8.61729  9.39484   31.74866 1.000 46.90362  ? 229 ARG B C   1 
ATOM   3645 O O   . ARG B 1 221 ? -8.60855  9.34733   32.98821 1.000 48.34813  ? 229 ARG B O   1 
ATOM   3646 C CB  . ARG B 1 221 ? -6.69877  9.77654   30.12620 1.000 43.39303  ? 229 ARG B CB  1 
ATOM   3647 C CG  . ARG B 1 221 ? -5.59762  9.10210   30.91625 1.000 44.40967  ? 229 ARG B CG  1 
ATOM   3648 C CD  . ARG B 1 221 ? -5.06429  7.87565   30.20127 1.000 48.63270  ? 229 ARG B CD  1 
ATOM   3649 N NE  . ARG B 1 221 ? -3.91573  7.31698   30.90038 1.000 45.90466  ? 229 ARG B NE  1 
ATOM   3650 C CZ  . ARG B 1 221 ? -3.96831  6.28255   31.72846 1.000 49.56891  ? 229 ARG B CZ  1 
ATOM   3651 N NH1 . ARG B 1 221 ? -5.09783  5.62562   31.94492 1.000 44.58109  ? 229 ARG B NH1 1 
ATOM   3652 N NH2 . ARG B 1 221 ? -2.86162  5.90400   32.36577 1.000 49.60009  ? 229 ARG B NH2 1 
ATOM   3653 N N   . PRO B 1 222 ? -9.39138  8.57596   31.02868 1.000 44.16314  ? 230 PRO B N   1 
ATOM   3654 C CA  . PRO B 1 222 ? -10.13830 7.50231   31.69840 1.000 41.02248  ? 230 PRO B CA  1 
ATOM   3655 C C   . PRO B 1 222 ? -9.21839  6.39847   32.20151 1.000 46.62073  ? 230 PRO B C   1 
ATOM   3656 O O   . PRO B 1 222 ? -8.09158  6.21849   31.73103 1.000 40.07185  ? 230 PRO B O   1 
ATOM   3657 C CB  . PRO B 1 222 ? -11.06501 6.97263   30.59853 1.000 42.35940  ? 230 PRO B CB  1 
ATOM   3658 C CG  . PRO B 1 222 ? -11.17489 8.09958   29.62181 1.000 44.96889  ? 230 PRO B CG  1 
ATOM   3659 C CD  . PRO B 1 222 ? -9.80960  8.71624   29.62293 1.000 43.16022  ? 230 PRO B CD  1 
ATOM   3660 N N   . LEU B 1 223 ? -9.72992  5.63789   33.16673 1.000 43.61188  ? 231 LEU B N   1 
ATOM   3661 C CA  . LEU B 1 223 ? -9.00710  4.46395   33.65463 1.000 46.60813  ? 231 LEU B CA  1 
ATOM   3662 C C   . LEU B 1 223 ? -8.67909  3.50343   32.50675 1.000 42.60528  ? 231 LEU B C   1 
ATOM   3663 O O   . LEU B 1 223 ? -9.51228  3.24632   31.62758 1.000 39.29268  ? 231 LEU B O   1 
ATOM   3664 C CB  . LEU B 1 223 ? -9.84255  3.75246   34.72546 1.000 42.54776  ? 231 LEU B CB  1 
ATOM   3665 C CG  . LEU B 1 223 ? -9.35532  2.46091   35.38440 1.000 45.02409  ? 231 LEU B CG  1 
ATOM   3666 C CD1 . LEU B 1 223 ? -8.04912  2.66954   36.12987 1.000 43.91893  ? 231 LEU B CD1 1 
ATOM   3667 C CD2 . LEU B 1 223 ? -10.44568 1.93340   36.33282 1.000 39.49269  ? 231 LEU B CD2 1 
ATOM   3668 N N   . ASP B 1 224 ? -7.44439  2.98675   32.51026 1.000 38.81259  ? 232 ASP B N   1 
ATOM   3669 C CA  . ASP B 1 224 ? -7.00505  2.01751   31.50674 1.000 38.40038  ? 232 ASP B CA  1 
ATOM   3670 C C   . ASP B 1 224 ? -7.65917  0.66556   31.78519 1.000 35.84643  ? 232 ASP B C   1 
ATOM   3671 O O   . ASP B 1 224 ? -7.41877  0.05627   32.83491 1.000 37.20493  ? 232 ASP B O   1 
ATOM   3672 C CB  . ASP B 1 224 ? -5.47087  1.90098   31.52737 1.000 40.38062  ? 232 ASP B CB  1 
ATOM   3673 C CG  . ASP B 1 224 ? -4.92654  0.71116   30.73034 1.000 39.82512  ? 232 ASP B CG  1 
ATOM   3674 O OD1 . ASP B 1 224 ? -5.64115  0.08125   29.90143 1.000 39.94409  ? 232 ASP B OD1 1 
ATOM   3675 O OD2 . ASP B 1 224 ? -3.73419  0.38440   30.95644 1.000 48.95401  ? 232 ASP B OD2 1 
ATOM   3676 N N   . LEU B 1 225 ? -8.45734  0.18361   30.82853 1.000 35.63090  ? 233 LEU B N   1 
ATOM   3677 C CA  . LEU B 1 225 ? -9.22612  -1.04950  30.97309 1.000 37.41251  ? 233 LEU B CA  1 
ATOM   3678 C C   . LEU B 1 225 ? -8.62044  -2.22540  30.19375 1.000 35.70374  ? 233 LEU B C   1 
ATOM   3679 O O   . LEU B 1 225 ? -9.33192  -3.17681  29.84752 1.000 32.48379  ? 233 LEU B O   1 
ATOM   3680 C CB  . LEU B 1 225 ? -10.67683 -0.79738  30.55843 1.000 35.39473  ? 233 LEU B CB  1 
ATOM   3681 C CG  . LEU B 1 225 ? -11.48385 0.18903   31.42542 1.000 37.42851  ? 233 LEU B CG  1 
ATOM   3682 C CD1 . LEU B 1 225 ? -12.88103 0.30672   30.90173 1.000 29.56884  ? 233 LEU B CD1 1 
ATOM   3683 C CD2 . LEU B 1 225 ? -11.52938 -0.22711  32.91061 1.000 33.40422  ? 233 LEU B CD2 1 
ATOM   3684 N N   . SER B 1 226 ? -7.30363  -2.19574  29.94524 1.000 39.33591  ? 234 SER B N   1 
ATOM   3685 C CA  . SER B 1 226 ? -6.64305  -3.27661  29.20430 1.000 37.15847  ? 234 SER B CA  1 
ATOM   3686 C C   . SER B 1 226 ? -6.93630  -4.65727  29.79041 1.000 37.15008  ? 234 SER B C   1 
ATOM   3687 O O   . SER B 1 226 ? -7.15797  -5.61591  29.04420 1.000 40.05853  ? 234 SER B O   1 
ATOM   3688 C CB  . SER B 1 226 ? -5.12334  -3.05105  29.15641 1.000 39.11036  ? 234 SER B CB  1 
ATOM   3689 O OG  . SER B 1 226 ? -4.76821  -1.95599  28.32086 1.000 39.20686  ? 234 SER B OG  1 
ATOM   3690 N N   . ASN B 1 227 ? -6.89082  -4.80180  31.11472 1.000 35.24074  ? 235 ASN B N   1 
ATOM   3691 C CA  . ASN B 1 227 ? -7.07643  -6.11540  31.72755 1.000 36.75013  ? 235 ASN B CA  1 
ATOM   3692 C C   . ASN B 1 227 ? -8.43092  -6.26023  32.42423 1.000 40.85933  ? 235 ASN B C   1 
ATOM   3693 O O   . ASN B 1 227 ? -8.56474  -7.06769  33.35209 1.000 39.69874  ? 235 ASN B O   1 
ATOM   3694 C CB  . ASN B 1 227 ? -5.94506  -6.39281  32.71801 1.000 40.68131  ? 235 ASN B CB  1 
ATOM   3695 C CG  . ASN B 1 227 ? -4.55777  -6.51912  32.03193 1.000 42.25427  ? 235 ASN B CG  1 
ATOM   3696 O OD1 . ASN B 1 227 ? -3.68642  -5.65911  32.20230 1.000 43.51940  ? 235 ASN B OD1 1 
ATOM   3697 N ND2 . ASN B 1 227 ? -4.35826  -7.59101  31.28192 1.000 37.20845  ? 235 ASN B ND2 1 
ATOM   3698 N N   . SER B 1 228 ? -9.43498  -5.47820  32.01601 1.000 40.80596  ? 236 SER B N   1 
ATOM   3699 C CA  . SER B 1 228 ? -10.74521 -5.48906  32.66131 1.000 35.26845  ? 236 SER B CA  1 
ATOM   3700 C C   . SER B 1 228 ? -11.68804 -6.50512  32.01821 1.000 32.77782  ? 236 SER B C   1 
ATOM   3701 O O   . SER B 1 228 ? -11.82101 -6.56140  30.79252 1.000 34.03431  ? 236 SER B O   1 
ATOM   3702 C CB  . SER B 1 228 ? -11.35158 -4.08569  32.61964 1.000 37.72555  ? 236 SER B CB  1 
ATOM   3703 O OG  . SER B 1 228 ? -12.76801 -4.10701  32.59551 1.000 40.58847  ? 236 SER B OG  1 
ATOM   3704 N N   . ALA B 1 229 ? -12.34952 -7.29803  32.85480 1.000 35.44847  ? 237 ALA B N   1 
ATOM   3705 C CA  . ALA B 1 229 ? -13.29467 -8.28993  32.34971 1.000 40.71499  ? 237 ALA B CA  1 
ATOM   3706 C C   . ALA B 1 229 ? -14.53034 -7.63411  31.75816 1.000 38.57889  ? 237 ALA B C   1 
ATOM   3707 O O   . ALA B 1 229 ? -15.09120 -8.13089  30.76966 1.000 37.03711  ? 237 ALA B O   1 
ATOM   3708 C CB  . ALA B 1 229 ? -13.70261 -9.24770  33.46900 1.000 39.70031  ? 237 ALA B CB  1 
ATOM   3709 N N   . LEU B 1 230 ? -14.94498 -6.50575  32.33053 1.000 42.78845  ? 238 LEU B N   1 
ATOM   3710 C CA  . LEU B 1 230 ? -16.18437 -5.82770  31.98819 1.000 34.48437  ? 238 LEU B CA  1 
ATOM   3711 C C   . LEU B 1 230 ? -15.99943 -4.73416  30.95478 1.000 34.97179  ? 238 LEU B C   1 
ATOM   3712 O O   . LEU B 1 230 ? -16.98351 -4.07033  30.61373 1.000 38.25398  ? 238 LEU B O   1 
ATOM   3713 C CB  . LEU B 1 230 ? -16.79669 -5.24927  33.25707 1.000 39.42499  ? 238 LEU B CB  1 
ATOM   3714 C CG  . LEU B 1 230 ? -17.12154 -6.30196  34.31310 1.000 39.32694  ? 238 LEU B CG  1 
ATOM   3715 C CD1 . LEU B 1 230 ? -17.44501 -5.65979  35.63875 1.000 37.64879  ? 238 LEU B CD1 1 
ATOM   3716 C CD2 . LEU B 1 230 ? -18.31032 -7.11280  33.82920 1.000 40.10511  ? 238 LEU B CD2 1 
ATOM   3717 N N   . ARG B 1 231 ? -14.77564 -4.53992  30.45456 1.000 36.53738  ? 239 ARG B N   1 
ATOM   3718 C CA  . ARG B 1 231 ? -14.46151 -3.48669  29.48722 1.000 33.51782  ? 239 ARG B CA  1 
ATOM   3719 C C   . ARG B 1 231 ? -15.46699 -3.45367  28.33754 1.000 36.41678  ? 239 ARG B C   1 
ATOM   3720 O O   . ARG B 1 231 ? -15.69755 -4.45812  27.65701 1.000 36.20197  ? 239 ARG B O   1 
ATOM   3721 C CB  . ARG B 1 231 ? -13.04295 -3.68214  28.92638 1.000 34.67400  ? 239 ARG B CB  1 
ATOM   3722 C CG  . ARG B 1 231 ? -12.68661 -2.64437  27.83409 1.000 33.41349  ? 239 ARG B CG  1 
ATOM   3723 C CD  . ARG B 1 231 ? -11.31277 -2.84556  27.14878 1.000 37.28190  ? 239 ARG B CD  1 
ATOM   3724 N NE  . ARG B 1 231 ? -10.95088 -4.23874  26.89323 1.000 37.76518  ? 239 ARG B NE  1 
ATOM   3725 C CZ  . ARG B 1 231 ? -11.20702 -4.88994  25.76069 1.000 41.68381  ? 239 ARG B CZ  1 
ATOM   3726 N NH1 . ARG B 1 231 ? -11.80415 -4.29563  24.73382 1.000 36.24348  ? 239 ARG B NH1 1 
ATOM   3727 N NH2 . ARG B 1 231 ? -10.85657 -6.17412  25.65434 1.000 35.87440  ? 239 ARG B NH2 1 
ATOM   3728 N N   . SER B 1 232 ? -16.04179 -2.27730  28.10092 1.000 37.21032  ? 240 SER B N   1 
ATOM   3729 C CA  . SER B 1 232 ? -17.02104 -2.09381  27.03708 1.000 35.71126  ? 240 SER B CA  1 
ATOM   3730 C C   . SER B 1 232 ? -16.36403 -2.28394  25.66956 1.000 35.07624  ? 240 SER B C   1 
ATOM   3731 O O   . SER B 1 232 ? -15.15619 -2.51403  25.54045 1.000 34.79225  ? 240 SER B O   1 
ATOM   3732 C CB  . SER B 1 232 ? -17.66680 -0.71230  27.14315 1.000 36.12856  ? 240 SER B CB  1 
ATOM   3733 O OG  . SER B 1 232 ? -16.70663 0.30698   26.88637 1.000 38.37584  ? 240 SER B OG  1 
ATOM   3734 N N   . VAL B 1 233 ? -17.18388 -2.23424  24.63239 1.000 35.74196  ? 241 VAL B N   1 
ATOM   3735 C CA  . VAL B 1 233 ? -16.78573 -2.64808  23.29537 1.000 37.29146  ? 241 VAL B CA  1 
ATOM   3736 C C   . VAL B 1 233 ? -16.81690 -1.46100  22.35584 1.000 36.68316  ? 241 VAL B C   1 
ATOM   3737 O O   . VAL B 1 233 ? -17.74130 -0.64290  22.40606 1.000 37.70291  ? 241 VAL B O   1 
ATOM   3738 C CB  . VAL B 1 233 ? -17.71640 -3.74420  22.75804 1.000 36.42928  ? 241 VAL B CB  1 
ATOM   3739 C CG1 . VAL B 1 233 ? -17.16440 -4.30700  21.45227 1.000 35.00834  ? 241 VAL B CG1 1 
ATOM   3740 C CG2 . VAL B 1 233 ? -17.96767 -4.78786  23.83742 1.000 35.70640  ? 241 VAL B CG2 1 
ATOM   3741 N N   . SER B 1 234 ? -15.81985 -1.40201  21.47575 1.000 38.83834  ? 242 SER B N   1 
ATOM   3742 C CA  . SER B 1 234 ? -15.77146 -0.40729  20.41946 1.000 42.23000  ? 242 SER B CA  1 
ATOM   3743 C C   . SER B 1 234 ? -17.14325 -0.30104  19.73792 1.000 38.39615  ? 242 SER B C   1 
ATOM   3744 O O   . SER B 1 234 ? -17.71147 -1.32565  19.33986 1.000 35.98470  ? 242 SER B O   1 
ATOM   3745 C CB  . SER B 1 234 ? -14.67643 -0.80005  19.42520 1.000 39.23448  ? 242 SER B CB  1 
ATOM   3746 O OG  . SER B 1 234 ? -14.88039 -0.23142  18.14862 1.000 42.43555  ? 242 SER B OG  1 
ATOM   3747 N N   . PRO B 1 235 ? -17.72676 0.89394   19.63743 1.000 37.79391  ? 243 PRO B N   1 
ATOM   3748 C CA  . PRO B 1 235 ? -19.05372 0.97924   19.00374 1.000 38.80627  ? 243 PRO B CA  1 
ATOM   3749 C C   . PRO B 1 235 ? -19.08679 0.39836   17.59619 1.000 42.50722  ? 243 PRO B C   1 
ATOM   3750 O O   . PRO B 1 235 ? -20.08035 -0.24302  17.22329 1.000 41.52709  ? 243 PRO B O   1 
ATOM   3751 C CB  . PRO B 1 235 ? -19.35951 2.48567   19.03383 1.000 35.94447  ? 243 PRO B CB  1 
ATOM   3752 C CG  . PRO B 1 235 ? -18.62670 2.99532   20.20529 1.000 37.79461  ? 243 PRO B CG  1 
ATOM   3753 C CD  . PRO B 1 235 ? -17.31870 2.18849   20.21478 1.000 40.36206  ? 243 PRO B CD  1 
ATOM   3754 N N   . VAL B 1 236 ? -18.02081 0.56248   16.80783 1.000 41.96727  ? 244 VAL B N   1 
ATOM   3755 C CA  . VAL B 1 236 ? -18.05917 0.03958   15.44493 1.000 41.08783  ? 244 VAL B CA  1 
ATOM   3756 C C   . VAL B 1 236 ? -18.13333 -1.49034  15.44822 1.000 41.87212  ? 244 VAL B C   1 
ATOM   3757 O O   . VAL B 1 236 ? -18.84666 -2.08293  14.63203 1.000 48.55160  ? 244 VAL B O   1 
ATOM   3758 C CB  . VAL B 1 236 ? -16.86933 0.57498   14.62238 1.000 47.42465  ? 244 VAL B CB  1 
ATOM   3759 C CG1 . VAL B 1 236 ? -15.58131 0.05172   15.15173 1.000 49.31966  ? 244 VAL B CG1 1 
ATOM   3760 C CG2 . VAL B 1 236 ? -17.00429 0.19679   13.14977 1.000 52.49555  ? 244 VAL B CG2 1 
ATOM   3761 N N   . HIS B 1 237 ? -17.42494 -2.16220  16.36826 1.000 40.22582  ? 245 HIS B N   1 
ATOM   3762 C CA  . HIS B 1 237 ? -17.49191 -3.62436  16.39316 1.000 35.70810  ? 245 HIS B CA  1 
ATOM   3763 C C   . HIS B 1 237 ? -18.79415 -4.11855  16.99371 1.000 37.63121  ? 245 HIS B C   1 
ATOM   3764 O O   . HIS B 1 237 ? -19.29275 -5.18452  16.61372 1.000 37.64561  ? 245 HIS B O   1 
ATOM   3765 C CB  . HIS B 1 237 ? -16.33699 -4.22322  17.19671 1.000 36.43650  ? 245 HIS B CB  1 
ATOM   3766 C CG  . HIS B 1 237 ? -16.36817 -5.72748  17.27279 1.000 36.58513  ? 245 HIS B CG  1 
ATOM   3767 N ND1 . HIS B 1 237 ? -16.20326 -6.53708  16.16460 1.000 37.50320  ? 245 HIS B ND1 1 
ATOM   3768 C CD2 . HIS B 1 237 ? -16.54710 -6.56478  18.32517 1.000 33.71192  ? 245 HIS B CD2 1 
ATOM   3769 C CE1 . HIS B 1 237 ? -16.28039 -7.80591  16.53281 1.000 38.23795  ? 245 HIS B CE1 1 
ATOM   3770 N NE2 . HIS B 1 237 ? -16.49073 -7.85169  17.83868 1.000 35.65373  ? 245 HIS B NE2 1 
ATOM   3771 N N   . LEU B 1 238 ? -19.31185 -3.40452  17.99054 1.000 37.11058  ? 246 LEU B N   1 
ATOM   3772 C CA  . LEU B 1 238 ? -20.60660 -3.76902  18.55231 1.000 40.08136  ? 246 LEU B CA  1 
ATOM   3773 C C   . LEU B 1 238 ? -21.69073 -3.68454  17.48712 1.000 39.92490  ? 246 LEU B C   1 
ATOM   3774 O O   . LEU B 1 238 ? -22.57638 -4.54317  17.41691 1.000 39.05375  ? 246 LEU B O   1 
ATOM   3775 C CB  . LEU B 1 238 ? -20.92761 -2.85682  19.73258 1.000 38.90379  ? 246 LEU B CB  1 
ATOM   3776 C CG  . LEU B 1 238 ? -21.73800 -3.46289  20.87067 1.000 45.09579  ? 246 LEU B CG  1 
ATOM   3777 C CD1 . LEU B 1 238 ? -20.93747 -4.57588  21.57113 1.000 36.58894  ? 246 LEU B CD1 1 
ATOM   3778 C CD2 . LEU B 1 238 ? -22.17049 -2.37186  21.84972 1.000 43.53525  ? 246 LEU B CD2 1 
ATOM   3779 N N   . GLU B 1 239 ? -21.61582 -2.66465  16.62750 1.000 40.62542  ? 247 GLU B N   1 
ATOM   3780 C CA  . GLU B 1 239 ? -22.58774 -2.51917  15.54602 1.000 42.03833  ? 247 GLU B CA  1 
ATOM   3781 C C   . GLU B 1 239 ? -22.43916 -3.62960  14.51927 1.000 44.83864  ? 247 GLU B C   1 
ATOM   3782 O O   . GLU B 1 239 ? -23.43433 -4.11517  13.96807 1.000 41.47427  ? 247 GLU B O   1 
ATOM   3783 C CB  . GLU B 1 239 ? -22.43331 -1.14800  14.88295 1.000 44.31347  ? 247 GLU B CB  1 
ATOM   3784 C CG  . GLU B 1 239 ? -23.67257 -0.61305  14.17277 1.000 52.74619  ? 247 GLU B CG  1 
ATOM   3785 C CD  . GLU B 1 239 ? -23.40826 0.73356   13.51840 1.000 63.17252  ? 247 GLU B CD  1 
ATOM   3786 O OE1 . GLU B 1 239 ? -22.31347 0.91001   12.93395 1.000 67.30446  ? 247 GLU B OE1 1 
ATOM   3787 O OE2 . GLU B 1 239 ? -24.28441 1.62603   13.60149 1.000 72.78110  ? 247 GLU B OE2 1 
ATOM   3788 N N   . TYR B 1 240 ? -21.20317 -4.04632  14.23901 1.000 45.07964  ? 248 TYR B N   1 
ATOM   3789 C CA  . TYR B 1 240 ? -21.01954 -5.14222  13.29955 1.000 41.91608  ? 248 TYR B CA  1 
ATOM   3790 C C   . TYR B 1 240 ? -21.57066 -6.44372  13.86471 1.000 41.12723  ? 248 TYR B C   1 
ATOM   3791 O O   . TYR B 1 240 ? -22.16436 -7.23883  13.12753 1.000 42.52764  ? 248 TYR B O   1 
ATOM   3792 C CB  . TYR B 1 240 ? -19.55144 -5.25540  12.91900 1.000 46.21571  ? 248 TYR B CB  1 
ATOM   3793 C CG  . TYR B 1 240 ? -19.10567 -6.61892  12.45581 1.000 45.85561  ? 248 TYR B CG  1 
ATOM   3794 C CD1 . TYR B 1 240 ? -19.32539 -7.05317  11.15023 1.000 45.44805  ? 248 TYR B CD1 1 
ATOM   3795 C CD2 . TYR B 1 240 ? -18.42841 -7.45360  13.31703 1.000 44.60921  ? 248 TYR B CD2 1 
ATOM   3796 C CE1 . TYR B 1 240 ? -18.88668 -8.30309  10.73083 1.000 46.60430  ? 248 TYR B CE1 1 
ATOM   3797 C CE2 . TYR B 1 240 ? -17.99371 -8.69236  12.91626 1.000 52.94960  ? 248 TYR B CE2 1 
ATOM   3798 C CZ  . TYR B 1 240 ? -18.21801 -9.11872  11.62790 1.000 52.55313  ? 248 TYR B CZ  1 
ATOM   3799 O OH  . TYR B 1 240 ? -17.75289 -10.37277 11.28217 1.000 55.74496  ? 248 TYR B OH  1 
ATOM   3800 N N   . LEU B 1 241 ? -21.40499 -6.67577  15.16877 1.000 35.75204  ? 249 LEU B N   1 
ATOM   3801 C CA  . LEU B 1 241 ? -22.04752 -7.83924  15.77877 1.000 37.97700  ? 249 LEU B CA  1 
ATOM   3802 C C   . LEU B 1 241 ? -23.57445 -7.76742  15.67137 1.000 42.35042  ? 249 LEU B C   1 
ATOM   3803 O O   . LEU B 1 241 ? -24.22139 -8.77174  15.34663 1.000 40.06459  ? 249 LEU B O   1 
ATOM   3804 C CB  . LEU B 1 241 ? -21.62800 -7.98593  17.24514 1.000 38.43380  ? 249 LEU B CB  1 
ATOM   3805 C CG  . LEU B 1 241 ? -20.17627 -8.35458  17.58895 1.000 37.19635  ? 249 LEU B CG  1 
ATOM   3806 C CD1 . LEU B 1 241 ? -19.97486 -8.39370  19.09396 1.000 29.65886  ? 249 LEU B CD1 1 
ATOM   3807 C CD2 . LEU B 1 241 ? -19.76918 -9.70148  16.95009 1.000 33.82553  ? 249 LEU B CD2 1 
ATOM   3808 N N   . ARG B 1 242 ? -24.17628 -6.59257  15.94165 1.000 39.94254  ? 250 ARG B N   1 
ATOM   3809 C CA  . ARG B 1 242 ? -25.64124 -6.48989  15.88821 1.000 42.01852  ? 250 ARG B CA  1 
ATOM   3810 C C   . ARG B 1 242 ? -26.17187 -6.80703  14.49471 1.000 43.22163  ? 250 ARG B C   1 
ATOM   3811 O O   . ARG B 1 242 ? -27.19152 -7.49344  14.35350 1.000 47.21527  ? 250 ARG B O   1 
ATOM   3812 C CB  . ARG B 1 242 ? -26.12121 -5.09494  16.33642 1.000 38.25313  ? 250 ARG B CB  1 
ATOM   3813 C CG  . ARG B 1 242 ? -26.13234 -4.94933  17.86552 1.000 41.34400  ? 250 ARG B CG  1 
ATOM   3814 C CD  . ARG B 1 242 ? -26.96559 -3.78269  18.39568 1.000 40.69956  ? 250 ARG B CD  1 
ATOM   3815 N NE  . ARG B 1 242 ? -26.43590 -2.49746  17.95501 1.000 41.61019  ? 250 ARG B NE  1 
ATOM   3816 C CZ  . ARG B 1 242 ? -25.46969 -1.83827  18.58252 1.000 44.44173  ? 250 ARG B CZ  1 
ATOM   3817 N NH1 . ARG B 1 242 ? -24.92267 -2.30229  19.70001 1.000 39.11970  ? 250 ARG B NH1 1 
ATOM   3818 N NH2 . ARG B 1 242 ? -25.03565 -0.68841  18.07576 1.000 46.38810  ? 250 ARG B NH2 1 
ATOM   3819 N N   . ASN B 1 243 ? -25.48987 -6.32074  13.45295 1.000 45.19301  ? 251 ASN B N   1 
ATOM   3820 C CA  . ASN B 1 243 ? -25.92711 -6.56194  12.08005 1.000 45.30927  ? 251 ASN B CA  1 
ATOM   3821 C C   . ASN B 1 243 ? -25.96763 -8.04332  11.75401 1.000 48.09185  ? 251 ASN B C   1 
ATOM   3822 O O   . ASN B 1 243 ? -26.70447 -8.45466  10.85246 1.000 52.72361  ? 251 ASN B O   1 
ATOM   3823 C CB  . ASN B 1 243 ? -25.00628 -5.84815  11.07905 1.000 50.28388  ? 251 ASN B CB  1 
ATOM   3824 C CG  . ASN B 1 243 ? -25.13329 -4.32815  11.12196 1.000 53.58686  ? 251 ASN B CG  1 
ATOM   3825 O OD1 . ASN B 1 243 ? -24.23925 -3.61124  10.66608 1.000 61.19481  ? 251 ASN B OD1 1 
ATOM   3826 N ND2 . ASN B 1 243 ? -26.26593 -3.83059  11.62228 1.000 56.92213  ? 251 ASN B ND2 1 
ATOM   3827 N N   . MET B 1 244 ? -25.17886 -8.85340  12.45066 1.000 43.63097  ? 252 MET B N   1 
ATOM   3828 C CA  . MET B 1 244 ? -25.15180 -10.29633 12.24246 1.000 45.51503  ? 252 MET B CA  1 
ATOM   3829 C C   . MET B 1 244 ? -26.19557 -11.02727 13.07249 1.000 45.93462  ? 252 MET B C   1 
ATOM   3830 O O   . MET B 1 244 ? -26.30391 -12.25605 12.98102 1.000 51.91625  ? 252 MET B O   1 
ATOM   3831 C CB  . MET B 1 244 ? -23.75655 -10.84266 12.56957 1.000 48.40631  ? 252 MET B CB  1 
ATOM   3832 C CG  . MET B 1 244 ? -22.75473 -10.65978 11.46536 1.000 49.54907  ? 252 MET B CG  1 
ATOM   3833 S SD  . MET B 1 244 ? -21.28224 -11.65639 11.76684 1.000 68.80429  ? 252 MET B SD  1 
ATOM   3834 C CE  . MET B 1 244 ? -20.88393 -11.18995 13.44981 1.000 48.13871  ? 252 MET B CE  1 
ATOM   3835 N N   . GLY B 1 245 ? -26.97334 -10.30765 13.86834 1.000 46.23414  ? 253 GLY B N   1 
ATOM   3836 C CA  . GLY B 1 245 ? -27.86372 -10.97155 14.79305 1.000 42.34570  ? 253 GLY B CA  1 
ATOM   3837 C C   . GLY B 1 245 ? -27.15151 -11.61917 15.95779 1.000 46.73025  ? 253 GLY B C   1 
ATOM   3838 O O   . GLY B 1 245 ? -27.72333 -12.48571 16.62334 1.000 43.52418  ? 253 GLY B O   1 
ATOM   3839 N N   . VAL B 1 246 ? -25.91328 -11.21777 16.23308 1.000 43.64878  ? 254 VAL B N   1 
ATOM   3840 C CA  . VAL B 1 246 ? -25.17341 -11.79528 17.34169 1.000 38.36518  ? 254 VAL B CA  1 
ATOM   3841 C C   . VAL B 1 246 ? -25.59914 -11.10235 18.62463 1.000 35.86376  ? 254 VAL B C   1 
ATOM   3842 O O   . VAL B 1 246 ? -25.61375 -9.87365  18.70237 1.000 43.83951  ? 254 VAL B O   1 
ATOM   3843 C CB  . VAL B 1 246 ? -23.65430 -11.67115 17.10829 1.000 41.78058  ? 254 VAL B CB  1 
ATOM   3844 C CG1 . VAL B 1 246 ? -22.87512 -12.03845 18.36748 1.000 32.94013  ? 254 VAL B CG1 1 
ATOM   3845 C CG2 . VAL B 1 246 ? -23.22441 -12.59336 15.96631 1.000 44.41655  ? 254 VAL B CG2 1 
ATOM   3846 N N   . GLY B 1 247 ? -25.95612 -11.88538 19.62676 1.000 39.09816  ? 255 GLY B N   1 
ATOM   3847 C CA  . GLY B 1 247 ? -26.16783 -11.37745 20.96639 1.000 37.26895  ? 255 GLY B CA  1 
ATOM   3848 C C   . GLY B 1 247 ? -24.91430 -11.49452 21.80172 1.000 37.10246  ? 255 GLY B C   1 
ATOM   3849 O O   . GLY B 1 247 ? -24.30103 -10.48702 22.16564 1.000 42.82694  ? 255 GLY B O   1 
ATOM   3850 N N   . ALA B 1 248 ? -24.51094 -12.71611 22.12951 1.000 41.26965  ? 256 ALA B N   1 
ATOM   3851 C CA  . ALA B 1 248 ? -23.28789 -12.92984 22.89487 1.000 35.75667  ? 256 ALA B CA  1 
ATOM   3852 C C   . ALA B 1 248 ? -22.10118 -13.25725 21.98614 1.000 37.76150  ? 256 ALA B C   1 
ATOM   3853 O O   . ALA B 1 248 ? -22.24142 -13.90850 20.94505 1.000 36.09469  ? 256 ALA B O   1 
ATOM   3854 C CB  . ALA B 1 248 ? -23.48434 -14.04660 23.92196 1.000 35.88683  ? 256 ALA B CB  1 
ATOM   3855 N N   . SER B 1 249 ? -20.91502 -12.83751 22.42784 1.000 33.54579  ? 257 SER B N   1 
ATOM   3856 C CA  . SER B 1 249 ? -19.65673 -13.11906 21.74556 1.000 35.50313  ? 257 SER B CA  1 
ATOM   3857 C C   . SER B 1 249 ? -18.59873 -13.45636 22.79109 1.000 33.54895  ? 257 SER B C   1 
ATOM   3858 O O   . SER B 1 249 ? -18.40509 -12.69505 23.74681 1.000 33.84635  ? 257 SER B O   1 
ATOM   3859 C CB  . SER B 1 249 ? -19.26139 -11.90769 20.89090 1.000 36.23717  ? 257 SER B CB  1 
ATOM   3860 O OG  . SER B 1 249 ? -17.93162 -11.92485 20.43333 1.000 36.77071  ? 257 SER B OG  1 
ATOM   3861 N N   . PHE B 1 250 ? -17.93055 -14.60589 22.62366 1.000 35.26661  ? 258 PHE B N   1 
ATOM   3862 C CA  . PHE B 1 250 ? -16.94999 -15.11076 23.59136 1.000 32.70048  ? 258 PHE B CA  1 
ATOM   3863 C C   . PHE B 1 250 ? -15.70657 -15.58472 22.84346 1.000 35.74531  ? 258 PHE B C   1 
ATOM   3864 O O   . PHE B 1 250 ? -15.80020 -16.49186 22.00702 1.000 33.30251  ? 258 PHE B O   1 
ATOM   3865 C CB  . PHE B 1 250 ? -17.54762 -16.25403 24.41533 1.000 32.81744  ? 258 PHE B CB  1 
ATOM   3866 C CG  . PHE B 1 250 ? -16.61101 -16.83070 25.43841 1.000 32.45219  ? 258 PHE B CG  1 
ATOM   3867 C CD1 . PHE B 1 250 ? -16.28175 -16.10460 26.57758 1.000 34.62909  ? 258 PHE B CD1 1 
ATOM   3868 C CD2 . PHE B 1 250 ? -16.07079 -18.10003 25.27681 1.000 31.77437  ? 258 PHE B CD2 1 
ATOM   3869 C CE1 . PHE B 1 250 ? -15.41579 -16.62495 27.53364 1.000 34.15576  ? 258 PHE B CE1 1 
ATOM   3870 C CE2 . PHE B 1 250 ? -15.19386 -18.62530 26.23400 1.000 33.93477  ? 258 PHE B CE2 1 
ATOM   3871 C CZ  . PHE B 1 250 ? -14.87027 -17.88619 27.36102 1.000 28.87877  ? 258 PHE B CZ  1 
ATOM   3872 N N   . SER B 1 251 ? -14.54160 -14.98999 23.14804 1.000 30.72688  ? 259 SER B N   1 
ATOM   3873 C CA  . SER B 1 251 ? -13.32006 -15.19353 22.36859 1.000 35.56728  ? 259 SER B CA  1 
ATOM   3874 C C   . SER B 1 251 ? -12.22881 -15.84284 23.21032 1.000 34.86931  ? 259 SER B C   1 
ATOM   3875 O O   . SER B 1 251 ? -12.03912 -15.48046 24.37837 1.000 34.39382  ? 259 SER B O   1 
ATOM   3876 C CB  . SER B 1 251 ? -12.72086 -13.87286 21.81505 1.000 34.18622  ? 259 SER B CB  1 
ATOM   3877 O OG  . SER B 1 251 ? -13.65688 -13.09633 21.09842 1.000 47.84782  ? 259 SER B OG  1 
ATOM   3878 N N   . LEU B 1 252 ? -11.46720 -16.74609 22.59199 1.000 28.03404  ? 260 LEU B N   1 
ATOM   3879 C CA  . LEU B 1 252 ? -10.32356 -17.38104 23.24949 1.000 34.68523  ? 260 LEU B CA  1 
ATOM   3880 C C   . LEU B 1 252 ? -9.09318  -17.06187 22.42698 1.000 30.13643  ? 260 LEU B C   1 
ATOM   3881 O O   . LEU B 1 252 ? -9.08240  -17.32633 21.21677 1.000 33.90115  ? 260 LEU B O   1 
ATOM   3882 C CB  . LEU B 1 252 ? -10.46729 -18.91450 23.36366 1.000 26.89094  ? 260 LEU B CB  1 
ATOM   3883 C CG  . LEU B 1 252 ? -11.57484 -19.58342 24.18113 1.000 34.47726  ? 260 LEU B CG  1 
ATOM   3884 C CD1 . LEU B 1 252 ? -12.93882 -19.35808 23.57166 1.000 34.03629  ? 260 LEU B CD1 1 
ATOM   3885 C CD2 . LEU B 1 252 ? -11.29898 -21.10905 24.26619 1.000 31.80843  ? 260 LEU B CD2 1 
ATOM   3886 N N   . SER B 1 253 ? -8.05001  -16.52491 23.07423 1.000 29.80838  ? 261 SER B N   1 
ATOM   3887 C CA  . SER B 1 253 ? -6.82780  -16.15799 22.36871 1.000 31.09031  ? 261 SER B CA  1 
ATOM   3888 C C   . SER B 1 253 ? -5.88305  -17.35058 22.31177 1.000 34.06218  ? 261 SER B C   1 
ATOM   3889 O O   . SER B 1 253 ? -5.60865  -17.97321 23.33664 1.000 35.81012  ? 261 SER B O   1 
ATOM   3890 C CB  . SER B 1 253 ? -6.14286  -14.97271 23.04734 1.000 31.34308  ? 261 SER B CB  1 
ATOM   3891 O OG  . SER B 1 253 ? -7.06895  -13.89693 23.18931 1.000 34.34079  ? 261 SER B OG  1 
ATOM   3892 N N   . LEU B 1 254 ? -5.37105  -17.64747 21.11788 1.000 32.43047  ? 262 LEU B N   1 
ATOM   3893 C CA  . LEU B 1 254 ? -4.40123  -18.71468 20.91159 1.000 32.62415  ? 262 LEU B CA  1 
ATOM   3894 C C   . LEU B 1 254 ? -3.02326  -18.07838 20.80525 1.000 35.56808  ? 262 LEU B C   1 
ATOM   3895 O O   . LEU B 1 254 ? -2.73562  -17.36945 19.83074 1.000 33.57992  ? 262 LEU B O   1 
ATOM   3896 C CB  . LEU B 1 254 ? -4.73110  -19.50543 19.64723 1.000 33.08237  ? 262 LEU B CB  1 
ATOM   3897 C CG  . LEU B 1 254 ? -6.05762  -20.27755 19.62750 1.000 32.77093  ? 262 LEU B CG  1 
ATOM   3898 C CD1 . LEU B 1 254 ? -6.25069  -21.01841 18.30592 1.000 31.75866  ? 262 LEU B CD1 1 
ATOM   3899 C CD2 . LEU B 1 254 ? -6.16209  -21.22778 20.82602 1.000 31.61870  ? 262 LEU B CD2 1 
ATOM   3900 N N   . LEU B 1 255 ? -2.17781  -18.33404 21.80041 1.000 33.89135  ? 263 LEU B N   1 
ATOM   3901 C CA  . LEU B 1 255 ? -0.80247  -17.87087 21.79829 1.000 37.16143  ? 263 LEU B CA  1 
ATOM   3902 C C   . LEU B 1 255 ? 0.11826   -19.02452 21.43952 1.000 40.66617  ? 263 LEU B C   1 
ATOM   3903 O O   . LEU B 1 255 ? -0.16297  -20.18489 21.74800 1.000 41.37371  ? 263 LEU B O   1 
ATOM   3904 C CB  . LEU B 1 255 ? -0.39201  -17.31303 23.15996 1.000 39.26465  ? 263 LEU B CB  1 
ATOM   3905 C CG  . LEU B 1 255 ? -1.18440  -16.16505 23.79973 1.000 43.30516  ? 263 LEU B CG  1 
ATOM   3906 C CD1 . LEU B 1 255 ? -0.38274  -15.60912 24.97792 1.000 43.70947  ? 263 LEU B CD1 1 
ATOM   3907 C CD2 . LEU B 1 255 ? -1.53817  -15.07915 22.80991 1.000 35.55000  ? 263 LEU B CD2 1 
ATOM   3908 N N   . LYS B 1 256 ? 1.22145   -18.68865 20.77400 1.000 41.88666  ? 264 LYS B N   1 
ATOM   3909 C CA  . LYS B 1 256 ? 2.33151   -19.60492 20.55228 1.000 43.71182  ? 264 LYS B CA  1 
ATOM   3910 C C   . LYS B 1 256 ? 3.60030   -18.92330 21.03812 1.000 45.33882  ? 264 LYS B C   1 
ATOM   3911 O O   . LYS B 1 256 ? 3.95899   -17.85460 20.53572 1.000 38.90871  ? 264 LYS B O   1 
ATOM   3912 C CB  . LYS B 1 256 ? 2.46644   -19.98387 19.07994 1.000 45.18826  ? 264 LYS B CB  1 
ATOM   3913 C CG  . LYS B 1 256 ? 3.66882   -20.87343 18.77490 1.000 49.10124  ? 264 LYS B CG  1 
ATOM   3914 C CD  . LYS B 1 256 ? 3.82568   -21.02978 17.27038 1.000 48.84581  ? 264 LYS B CD  1 
ATOM   3915 C CE  . LYS B 1 256 ? 5.03152   -21.88094 16.90477 1.000 58.72609  ? 264 LYS B CE  1 
ATOM   3916 N NZ  . LYS B 1 256 ? 5.12478   -22.02249 15.42671 1.000 53.66552  ? 264 LYS B NZ  1 
ATOM   3917 N N   . GLU B 1 257 ? 4.25602   -19.52412 22.02722 1.000 44.37279  ? 265 GLU B N   1 
ATOM   3918 C CA  . GLU B 1 257 ? 5.47030   -18.96398 22.59562 1.000 49.83399  ? 265 GLU B CA  1 
ATOM   3919 C C   . GLU B 1 257 ? 5.25404   -17.49688 22.97231 1.000 47.15030  ? 265 GLU B C   1 
ATOM   3920 O O   . GLU B 1 257 ? 6.04879   -16.61170 22.63718 1.000 46.85370  ? 265 GLU B O   1 
ATOM   3921 C CB  . GLU B 1 257 ? 6.64345   -19.14528 21.62312 1.000 48.46262  ? 265 GLU B CB  1 
ATOM   3922 C CG  . GLU B 1 257 ? 7.21364   -20.56569 21.66340 1.000 58.42117  ? 265 GLU B CG  1 
ATOM   3923 C CD  . GLU B 1 257 ? 7.78126   -21.03482 20.32794 1.000 64.87163  ? 265 GLU B CD  1 
ATOM   3924 O OE1 . GLU B 1 257 ? 8.37052   -20.20277 19.59927 1.000 61.63497  ? 265 GLU B OE1 1 
ATOM   3925 O OE2 . GLU B 1 257 ? 7.64819   -22.25011 20.02214 1.000 62.61996  ? 265 GLU B OE2 1 
ATOM   3926 N N   . GLY B 1 258 ? 4.14245   -17.24412 23.66727 1.000 41.08488  ? 266 GLY B N   1 
ATOM   3927 C CA  . GLY B 1 258 ? 3.84059   -15.92435 24.18660 1.000 41.08074  ? 266 GLY B CA  1 
ATOM   3928 C C   . GLY B 1 258 ? 3.43988   -14.89495 23.15245 1.000 42.22581  ? 266 GLY B C   1 
ATOM   3929 O O   . GLY B 1 258 ? 3.15728   -13.75242 23.52571 1.000 40.44208  ? 266 GLY B O   1 
ATOM   3930 N N   . VAL B 1 259 ? 3.32850   -15.28227 21.88230 1.000 41.96415  ? 267 VAL B N   1 
ATOM   3931 C CA  . VAL B 1 259 ? 2.96021   -14.39903 20.78729 1.000 40.26420  ? 267 VAL B CA  1 
ATOM   3932 C C   . VAL B 1 259 ? 1.59843   -14.81975 20.24574 1.000 44.05291  ? 267 VAL B C   1 
ATOM   3933 O O   . VAL B 1 259 ? 1.30798   -16.01943 20.13199 1.000 41.44509  ? 267 VAL B O   1 
ATOM   3934 C CB  . VAL B 1 259 ? 4.03686   -14.44120 19.69046 1.000 48.13500  ? 267 VAL B CB  1 
ATOM   3935 C CG1 . VAL B 1 259 ? 3.49507   -13.94720 18.34597 1.000 45.76496  ? 267 VAL B CG1 1 
ATOM   3936 C CG2 . VAL B 1 259 ? 5.28845   -13.64599 20.14810 1.000 49.44092  ? 267 VAL B CG2 1 
ATOM   3937 N N   . LEU B 1 260 ? 0.75905   -13.82546 19.92509 1.000 39.63161  ? 268 LEU B N   1 
ATOM   3938 C CA  . LEU B 1 260 ? -0.59046  -14.09531 19.43780 1.000 37.61715  ? 268 LEU B CA  1 
ATOM   3939 C C   . LEU B 1 260 ? -0.52142  -14.84738 18.12033 1.000 37.25627  ? 268 LEU B C   1 
ATOM   3940 O O   . LEU B 1 260 ? 0.13665   -14.40888 17.17374 1.000 40.08716  ? 268 LEU B O   1 
ATOM   3941 C CB  . LEU B 1 260 ? -1.37078  -12.79194 19.25516 1.000 33.67595  ? 268 LEU B CB  1 
ATOM   3942 C CG  . LEU B 1 260 ? -2.83241  -12.95960 18.81666 1.000 39.24842  ? 268 LEU B CG  1 
ATOM   3943 C CD1 . LEU B 1 260 ? -3.60059  -13.63305 19.92224 1.000 26.72859  ? 268 LEU B CD1 1 
ATOM   3944 C CD2 . LEU B 1 260 ? -3.49981  -11.62728 18.38872 1.000 35.84767  ? 268 LEU B CD2 1 
ATOM   3945 N N   . TRP B 1 261 ? -1.20272  -15.98801 18.07073 1.000 35.39392  ? 269 TRP B N   1 
ATOM   3946 C CA  . TRP B 1 261 ? -1.22767  -16.88429 16.92485 1.000 38.40403  ? 269 TRP B CA  1 
ATOM   3947 C C   . TRP B 1 261 ? -2.60805  -16.98679 16.28084 1.000 38.45512  ? 269 TRP B C   1 
ATOM   3948 O O   . TRP B 1 261 ? -2.71935  -17.16943 15.06438 1.000 39.36589  ? 269 TRP B O   1 
ATOM   3949 C CB  . TRP B 1 261 ? -0.74579  -18.27359 17.37683 1.000 38.60450  ? 269 TRP B CB  1 
ATOM   3950 C CG  . TRP B 1 261 ? -0.59264  -19.35716 16.32089 1.000 42.15755  ? 269 TRP B CG  1 
ATOM   3951 C CD1 . TRP B 1 261 ? 0.56692   -19.70550 15.65408 1.000 41.39114  ? 269 TRP B CD1 1 
ATOM   3952 C CD2 . TRP B 1 261 ? -1.60377  -20.26564 15.85980 1.000 36.97653  ? 269 TRP B CD2 1 
ATOM   3953 N NE1 . TRP B 1 261 ? 0.31598   -20.75172 14.79987 1.000 41.28548  ? 269 TRP B NE1 1 
ATOM   3954 C CE2 . TRP B 1 261 ? -1.00477  -21.11239 14.90735 1.000 43.10819  ? 269 TRP B CE2 1 
ATOM   3955 C CE3 . TRP B 1 261 ? -2.94924  -20.44900 16.16361 1.000 36.78522  ? 269 TRP B CE3 1 
ATOM   3956 C CZ2 . TRP B 1 261 ? -1.71381  -22.11586 14.25440 1.000 42.51589  ? 269 TRP B CZ2 1 
ATOM   3957 C CZ3 . TRP B 1 261 ? -3.65236  -21.44630 15.50030 1.000 41.59534  ? 269 TRP B CZ3 1 
ATOM   3958 C CH2 . TRP B 1 261 ? -3.03453  -22.26295 14.56229 1.000 42.61948  ? 269 TRP B CH2 1 
ATOM   3959 N N   . GLY B 1 262 ? -3.66403  -16.89655 17.06638 1.000 35.24260  ? 270 GLY B N   1 
ATOM   3960 C CA  . GLY B 1 262 ? -4.97748  -17.07835 16.49056 1.000 36.08689  ? 270 GLY B CA  1 
ATOM   3961 C C   . GLY B 1 262 ? -6.03007  -16.78669 17.52817 1.000 35.55386  ? 270 GLY B C   1 
ATOM   3962 O O   . GLY B 1 262 ? -5.73299  -16.43362 18.67134 1.000 36.48517  ? 270 GLY B O   1 
ATOM   3963 N N   . LEU B 1 263 ? -7.27706  -16.96324 17.11844 1.000 35.98060  ? 271 LEU B N   1 
ATOM   3964 C CA  . LEU B 1 263 ? -8.41082  -16.59666 17.95084 1.000 34.93546  ? 271 LEU B CA  1 
ATOM   3965 C C   . LEU B 1 263 ? -9.52940  -17.61312 17.74969 1.000 34.77733  ? 271 LEU B C   1 
ATOM   3966 O O   . LEU B 1 263 ? -9.86850  -17.95398 16.61090 1.000 35.69697  ? 271 LEU B O   1 
ATOM   3967 C CB  . LEU B 1 263 ? -8.88922  -15.18149 17.59464 1.000 35.54121  ? 271 LEU B CB  1 
ATOM   3968 C CG  . LEU B 1 263 ? -9.78000  -14.38981 18.57058 1.000 39.23769  ? 271 LEU B CG  1 
ATOM   3969 C CD1 . LEU B 1 263 ? -9.02173  -14.12104 19.85317 1.000 35.87732  ? 271 LEU B CD1 1 
ATOM   3970 C CD2 . LEU B 1 263 ? -10.23421 -13.08116 17.94683 1.000 34.13750  ? 271 LEU B CD2 1 
ATOM   3971 N N   . ILE B 1 264 ? -10.10299 -18.09164 18.84291 1.000 29.65651  ? 272 ILE B N   1 
ATOM   3972 C CA  . ILE B 1 264 ? -11.33180 -18.87337 18.78165 1.000 37.21414  ? 272 ILE B CA  1 
ATOM   3973 C C   . ILE B 1 264 ? -12.47862 -17.93854 19.14471 1.000 33.67983  ? 272 ILE B C   1 
ATOM   3974 O O   . ILE B 1 264 ? -12.56891 -17.47032 20.28323 1.000 34.32292  ? 272 ILE B O   1 
ATOM   3975 C CB  . ILE B 1 264 ? -11.28029 -20.08653 19.71501 1.000 34.96637  ? 272 ILE B CB  1 
ATOM   3976 C CG1 . ILE B 1 264 ? -10.15180 -21.03570 19.27850 1.000 31.84128  ? 272 ILE B CG1 1 
ATOM   3977 C CG2 . ILE B 1 264 ? -12.64352 -20.74642 19.74670 1.000 33.84939  ? 272 ILE B CG2 1 
ATOM   3978 C CD1 . ILE B 1 264 ? -9.93308  -22.20392 20.21018 1.000 30.79301  ? 272 ILE B CD1 1 
ATOM   3979 N N   . ALA B 1 265 ? -13.36624 -17.68152 18.18405 1.000 36.17516  ? 273 ALA B N   1 
ATOM   3980 C CA  . ALA B 1 265 ? -14.44438 -16.71255 18.32977 1.000 36.08718  ? 273 ALA B CA  1 
ATOM   3981 C C   . ALA B 1 265 ? -15.78579 -17.43613 18.35053 1.000 38.31558  ? 273 ALA B C   1 
ATOM   3982 O O   . ALA B 1 265 ? -16.15801 -18.08124 17.36617 1.000 40.77400  ? 273 ALA B O   1 
ATOM   3983 C CB  . ALA B 1 265 ? -14.39135 -15.68961 17.19495 1.000 36.90818  ? 273 ALA B CB  1 
ATOM   3984 N N   . CYS B 1 266 ? -16.51596 -17.30614 19.46079 1.000 35.97647  ? 274 CYS B N   1 
ATOM   3985 C CA  . CYS B 1 266 ? -17.82191 -17.93082 19.64784 1.000 34.05956  ? 274 CYS B CA  1 
ATOM   3986 C C   . CYS B 1 266 ? -18.93393 -16.89006 19.54430 1.000 37.59698  ? 274 CYS B C   1 
ATOM   3987 O O   . CYS B 1 266 ? -18.88590 -15.84868 20.20854 1.000 32.15318  ? 274 CYS B O   1 
ATOM   3988 C CB  . CYS B 1 266 ? -17.88194 -18.63166 21.00561 1.000 29.57525  ? 274 CYS B CB  1 
ATOM   3989 S SG  . CYS B 1 266 ? -16.31565 -19.51719 21.32772 1.000 33.15432  ? 274 CYS B SG  1 
ATOM   3990 N N   . HIS B 1 267 ? -19.94723 -17.19201 18.73765 1.000 39.81503  ? 275 HIS B N   1 
ATOM   3991 C CA  . HIS B 1 267 ? -21.08825 -16.30892 18.53289 1.000 38.20618  ? 275 HIS B CA  1 
ATOM   3992 C C   . HIS B 1 267 ? -22.39262 -17.04262 18.84468 1.000 39.68907  ? 275 HIS B C   1 
ATOM   3993 O O   . HIS B 1 267 ? -22.57157 -18.21805 18.48605 1.000 36.50659  ? 275 HIS B O   1 
ATOM   3994 C CB  . HIS B 1 267 ? -21.08389 -15.74889 17.09924 1.000 39.85081  ? 275 HIS B CB  1 
ATOM   3995 C CG  . HIS B 1 267 ? -19.98408 -14.76041 16.84611 1.000 40.37630  ? 275 HIS B CG  1 
ATOM   3996 N ND1 . HIS B 1 267 ? -19.57912 -14.39632 15.57990 1.000 38.49509  ? 275 HIS B ND1 1 
ATOM   3997 C CD2 . HIS B 1 267 ? -19.20979 -14.04787 17.70391 1.000 42.36872  ? 275 HIS B CD2 1 
ATOM   3998 C CE1 . HIS B 1 267 ? -18.60561 -13.50450 15.66574 1.000 42.30646  ? 275 HIS B CE1 1 
ATOM   3999 N NE2 . HIS B 1 267 ? -18.35382 -13.28222 16.94397 1.000 38.02254  ? 275 HIS B NE2 1 
ATOM   4000 N N   . HIS B 1 268 ? -23.27309 -16.35234 19.57444 1.000 36.34125  ? 276 HIS B N   1 
ATOM   4001 C CA  . HIS B 1 268 ? -24.58709 -16.83940 19.94384 1.000 36.57552  ? 276 HIS B CA  1 
ATOM   4002 C C   . HIS B 1 268 ? -25.64212 -15.76649 19.66372 1.000 43.08944  ? 276 HIS B C   1 
ATOM   4003 O O   . HIS B 1 268 ? -25.42267 -14.57852 19.93136 1.000 40.45682  ? 276 HIS B O   1 
ATOM   4004 C CB  . HIS B 1 268 ? -24.61359 -17.23690 21.42338 1.000 36.97313  ? 276 HIS B CB  1 
ATOM   4005 C CG  . HIS B 1 268 ? -25.75818 -18.13929 21.78322 1.000 42.44203  ? 276 HIS B CG  1 
ATOM   4006 N ND1 . HIS B 1 268 ? -25.89418 -19.41114 21.26310 1.000 42.33903  ? 276 HIS B ND1 1 
ATOM   4007 C CD2 . HIS B 1 268 ? -26.81588 -17.95535 22.60975 1.000 37.69231  ? 276 HIS B CD2 1 
ATOM   4008 C CE1 . HIS B 1 268 ? -26.98276 -19.97133 21.75660 1.000 42.65620  ? 276 HIS B CE1 1 
ATOM   4009 N NE2 . HIS B 1 268 ? -27.56117 -19.10762 22.57296 1.000 42.34789  ? 276 HIS B NE2 1 
ATOM   4010 N N   . LEU B 1 269 ? -26.80284 -16.19081 19.15139 1.000 40.53263  ? 277 LEU B N   1 
ATOM   4011 C CA  . LEU B 1 269 ? -27.82175 -15.23518 18.73156 1.000 43.73899  ? 277 LEU B CA  1 
ATOM   4012 C C   . LEU B 1 269 ? -28.48339 -14.50806 19.89391 1.000 41.60562  ? 277 LEU B C   1 
ATOM   4013 O O   . LEU B 1 269 ? -29.17776 -13.51628 19.66369 1.000 47.95229  ? 277 LEU B O   1 
ATOM   4014 C CB  . LEU B 1 269 ? -28.89927 -15.91951 17.88217 1.000 47.11542  ? 277 LEU B CB  1 
ATOM   4015 C CG  . LEU B 1 269 ? -28.45055 -16.47917 16.52709 1.000 55.79073  ? 277 LEU B CG  1 
ATOM   4016 C CD1 . LEU B 1 269 ? -29.41631 -17.54469 15.98631 1.000 53.20569  ? 277 LEU B CD1 1 
ATOM   4017 C CD2 . LEU B 1 269 ? -28.28814 -15.33634 15.52995 1.000 59.02850  ? 277 LEU B CD2 1 
ATOM   4018 N N   . GLU B 1 270 ? -28.29934 -14.95853 21.12070 1.000 42.38860  ? 278 GLU B N   1 
ATOM   4019 C CA  . GLU B 1 270 ? -28.83776 -14.25141 22.27291 1.000 43.70683  ? 278 GLU B CA  1 
ATOM   4020 C C   . GLU B 1 270 ? -27.87053 -14.41242 23.43377 1.000 40.77590  ? 278 GLU B C   1 
ATOM   4021 O O   . GLU B 1 270 ? -26.87940 -15.14869 23.33270 1.000 42.44195  ? 278 GLU B O   1 
ATOM   4022 C CB  . GLU B 1 270 ? -30.24486 -14.75836 22.62711 1.000 44.07777  ? 278 GLU B CB  1 
ATOM   4023 C CG  . GLU B 1 270 ? -30.35801 -16.24608 22.86322 1.000 44.06541  ? 278 GLU B CG  1 
ATOM   4024 C CD  . GLU B 1 270 ? -31.81776 -16.70674 22.91616 1.000 49.83886  ? 278 GLU B CD  1 
ATOM   4025 O OE1 . GLU B 1 270 ? -32.68304 -16.10656 22.23595 1.000 53.89940  ? 278 GLU B OE1 1 
ATOM   4026 O OE2 . GLU B 1 270 ? -32.10290 -17.67106 23.64272 1.000 51.44045  ? 278 GLU B OE2 1 
ATOM   4027 N N   . PRO B 1 271 ? -28.09211 -13.69231 24.53290 1.000 37.17821  ? 279 PRO B N   1 
ATOM   4028 C CA  . PRO B 1 271 ? -27.29253 -13.94357 25.73837 1.000 41.87080  ? 279 PRO B CA  1 
ATOM   4029 C C   . PRO B 1 271 ? -27.38962 -15.38867 26.20700 1.000 45.43846  ? 279 PRO B C   1 
ATOM   4030 O O   . PRO B 1 271 ? -28.44954 -16.01713 26.14960 1.000 40.76742  ? 279 PRO B O   1 
ATOM   4031 C CB  . PRO B 1 271 ? -27.88015 -12.97350 26.76532 1.000 37.39516  ? 279 PRO B CB  1 
ATOM   4032 C CG  . PRO B 1 271 ? -28.32948 -11.83030 25.92508 1.000 43.34895  ? 279 PRO B CG  1 
ATOM   4033 C CD  . PRO B 1 271 ? -28.84637 -12.43349 24.63960 1.000 41.03413  ? 279 PRO B CD  1 
ATOM   4034 N N   . LEU B 1 272 ? -26.25285 -15.90926 26.67361 1.000 41.21456  ? 280 LEU B N   1 
ATOM   4035 C CA  . LEU B 1 272 ? -26.18364 -17.25167 27.23801 1.000 38.66284  ? 280 LEU B CA  1 
ATOM   4036 C C   . LEU B 1 272 ? -25.02465 -17.26637 28.22186 1.000 41.00748  ? 280 LEU B C   1 
ATOM   4037 O O   . LEU B 1 272 ? -23.86170 -17.14079 27.82079 1.000 40.98252  ? 280 LEU B O   1 
ATOM   4038 C CB  . LEU B 1 272 ? -26.01065 -18.29900 26.14174 1.000 39.94275  ? 280 LEU B CB  1 
ATOM   4039 C CG  . LEU B 1 272 ? -25.76521 -19.76797 26.50855 1.000 38.86479  ? 280 LEU B CG  1 
ATOM   4040 C CD1 . LEU B 1 272 ? -26.77264 -20.32227 27.50131 1.000 40.90610  ? 280 LEU B CD1 1 
ATOM   4041 C CD2 . LEU B 1 272 ? -25.79370 -20.58386 25.23181 1.000 41.59445  ? 280 LEU B CD2 1 
ATOM   4042 N N   . HIS B 1 273 ? -25.34238 -17.36027 29.50574 1.000 37.79776  ? 281 HIS B N   1 
ATOM   4043 C CA  . HIS B 1 273 ? -24.29838 -17.40808 30.51533 1.000 41.76844  ? 281 HIS B CA  1 
ATOM   4044 C C   . HIS B 1 273 ? -23.40636 -18.62976 30.28022 1.000 41.94236  ? 281 HIS B C   1 
ATOM   4045 O O   . HIS B 1 273 ? -23.88685 -19.71263 29.94137 1.000 39.59032  ? 281 HIS B O   1 
ATOM   4046 C CB  . HIS B 1 273 ? -24.94274 -17.46551 31.89921 1.000 38.55569  ? 281 HIS B CB  1 
ATOM   4047 C CG  . HIS B 1 273 ? -23.96459 -17.35499 33.02444 1.000 44.37775  ? 281 HIS B CG  1 
ATOM   4048 N ND1 . HIS B 1 273 ? -23.28905 -16.18815 33.30484 1.000 38.05909  ? 281 HIS B ND1 1 
ATOM   4049 C CD2 . HIS B 1 273 ? -23.54953 -18.26205 33.94174 1.000 45.09700  ? 281 HIS B CD2 1 
ATOM   4050 C CE1 . HIS B 1 273 ? -22.49837 -16.38117 34.34515 1.000 42.14878  ? 281 HIS B CE1 1 
ATOM   4051 N NE2 . HIS B 1 273 ? -22.64178 -17.62818 34.75379 1.000 43.31240  ? 281 HIS B NE2 1 
ATOM   4052 N N   . ILE B 1 274 ? -22.09741 -18.46604 30.43196 1.000 38.60390  ? 282 ILE B N   1 
ATOM   4053 C CA  . ILE B 1 274 ? -21.23635 -19.62729 30.21327 1.000 40.25381  ? 282 ILE B CA  1 
ATOM   4054 C C   . ILE B 1 274 ? -20.93454 -20.36768 31.51655 1.000 40.93537  ? 282 ILE B C   1 
ATOM   4055 O O   . ILE B 1 274 ? -20.96281 -21.60116 31.53407 1.000 49.16445  ? 282 ILE B O   1 
ATOM   4056 C CB  . ILE B 1 274 ? -19.95674 -19.23546 29.44411 1.000 37.46870  ? 282 ILE B CB  1 
ATOM   4057 C CG1 . ILE B 1 274 ? -20.32356 -19.02214 27.96796 1.000 35.90063  ? 282 ILE B CG1 1 
ATOM   4058 C CG2 . ILE B 1 274 ? -18.91894 -20.34392 29.52592 1.000 36.24909  ? 282 ILE B CG2 1 
ATOM   4059 C CD1 . ILE B 1 274 ? -19.30780 -18.34180 27.13649 1.000 31.57495  ? 282 ILE B CD1 1 
ATOM   4060 N N   . SER B 1 275 ? -20.65289 -19.65491 32.60937 1.000 39.35677  ? 283 SER B N   1 
ATOM   4061 C CA  . SER B 1 275 ? -20.43529 -20.22596 33.95312 1.000 46.44044  ? 283 SER B CA  1 
ATOM   4062 C C   . SER B 1 275 ? -18.96303 -20.52623 34.18807 1.000 43.10074  ? 283 SER B C   1 
ATOM   4063 O O   . SER B 1 275 ? -18.24369 -20.91652 33.25840 1.000 39.97294  ? 283 SER B O   1 
ATOM   4064 C CB  . SER B 1 275 ? -21.27180 -21.48485 34.23578 1.000 45.28231  ? 283 SER B CB  1 
ATOM   4065 O OG  . SER B 1 275 ? -20.56457 -22.67579 33.93167 1.000 48.38659  ? 283 SER B OG  1 
ATOM   4066 N N   . HIS B 1 276 ? -18.51109 -20.31387 35.42979 1.000 45.68375  ? 284 HIS B N   1 
ATOM   4067 C CA  . HIS B 1 276 ? -17.07994 -20.15932 35.68582 1.000 47.99633  ? 284 HIS B CA  1 
ATOM   4068 C C   . HIS B 1 276 ? -16.32586 -21.45239 35.41399 1.000 43.39190  ? 284 HIS B C   1 
ATOM   4069 O O   . HIS B 1 276 ? -15.25893 -21.42782 34.79211 1.000 47.12377  ? 284 HIS B O   1 
ATOM   4070 C CB  . HIS B 1 276 ? -16.84289 -19.69652 37.12294 1.000 49.04077  ? 284 HIS B CB  1 
ATOM   4071 C CG  . HIS B 1 276 ? -15.39935 -19.43753 37.44444 1.000 58.92047  ? 284 HIS B CG  1 
ATOM   4072 N ND1 . HIS B 1 276 ? -14.66610 -20.25135 38.28521 1.000 56.94112  ? 284 HIS B ND1 1 
ATOM   4073 C CD2 . HIS B 1 276 ? -14.55194 -18.45859 37.03528 1.000 61.93039  ? 284 HIS B CD2 1 
ATOM   4074 C CE1 . HIS B 1 276 ? -13.42894 -19.79029 38.37071 1.000 63.34844  ? 284 HIS B CE1 1 
ATOM   4075 N NE2 . HIS B 1 276 ? -13.33461 -18.69894 37.62938 1.000 64.00209  ? 284 HIS B NE2 1 
ATOM   4076 N N   . GLU B 1 277 ? -16.87685 -22.58257 35.86758 1.000 43.74689  ? 285 GLU B N   1 
ATOM   4077 C CA  . GLU B 1 277 ? -16.30300 -23.89851 35.59538 1.000 41.46861  ? 285 GLU B CA  1 
ATOM   4078 C C   . GLU B 1 277 ? -15.93752 -24.04692 34.12585 1.000 37.23893  ? 285 GLU B C   1 
ATOM   4079 O O   . GLU B 1 277 ? -14.82403 -24.46804 33.79978 1.000 35.64380  ? 285 GLU B O   1 
ATOM   4080 C CB  . GLU B 1 277 ? -17.29288 -24.99463 36.03544 1.000 42.05062  ? 285 GLU B CB  1 
ATOM   4081 C CG  . GLU B 1 277 ? -18.79231 -24.60303 35.74265 1.000 49.62349  ? 285 GLU B CG  1 
ATOM   4082 C CD  . GLU B 1 277 ? -19.78729 -25.77682 35.64248 1.000 56.84434  ? 285 GLU B CD  1 
ATOM   4083 O OE1 . GLU B 1 277 ? -20.65842 -25.75583 34.72049 1.000 53.30113  ? 285 GLU B OE1 1 
ATOM   4084 O OE2 . GLU B 1 277 ? -19.73210 -26.69077 36.50983 1.000 58.82875  ? 285 GLU B OE2 1 
ATOM   4085 N N   . ARG B 1 278 ? -16.86980 -23.70747 33.21446 1.000 35.72373  ? 286 ARG B N   1 
ATOM   4086 C CA  . ARG B 1 278 ? -16.63600 -23.90982 31.78270 1.000 36.30896  ? 286 ARG B CA  1 
ATOM   4087 C C   . ARG B 1 278 ? -15.81133 -22.78211 31.15072 1.000 36.79770  ? 286 ARG B C   1 
ATOM   4088 O O   . ARG B 1 278 ? -15.13112 -23.01197 30.13890 1.000 35.50475  ? 286 ARG B O   1 
ATOM   4089 C CB  . ARG B 1 278 ? -17.96862 -24.14170 31.06701 1.000 37.42552  ? 286 ARG B CB  1 
ATOM   4090 C CG  . ARG B 1 278 ? -18.64014 -25.46917 31.51708 1.000 37.72851  ? 286 ARG B CG  1 
ATOM   4091 C CD  . ARG B 1 278 ? -20.01419 -25.76590 30.87973 1.000 45.29288  ? 286 ARG B CD  1 
ATOM   4092 N NE  . ARG B 1 278 ? -20.21086 -27.20552 30.70233 1.000 49.01968  ? 286 ARG B NE  1 
ATOM   4093 C CZ  . ARG B 1 278 ? -21.36997 -27.79673 30.42345 1.000 48.28172  ? 286 ARG B CZ  1 
ATOM   4094 N NH1 . ARG B 1 278 ? -22.48928 -27.10328 30.30944 1.000 57.63673  ? 286 ARG B NH1 1 
ATOM   4095 N NH2 . ARG B 1 278 ? -21.41936 -29.12777 30.32473 1.000 42.75715  ? 286 ARG B NH2 1 
ATOM   4096 N N   . ARG B 1 279 ? -15.81017 -21.58586 31.73880 1.000 34.60338  ? 287 ARG B N   1 
ATOM   4097 C CA  . ARG B 1 279 ? -14.82350 -20.58263 31.33791 1.000 37.73484  ? 287 ARG B CA  1 
ATOM   4098 C C   . ARG B 1 279 ? -13.42371 -21.04403 31.69540 1.000 34.00002  ? 287 ARG B C   1 
ATOM   4099 O O   . ARG B 1 279 ? -12.51072 -20.99272 30.86980 1.000 33.11267  ? 287 ARG B O   1 
ATOM   4100 C CB  . ARG B 1 279 ? -15.10826 -19.24163 32.00606 1.000 37.41382  ? 287 ARG B CB  1 
ATOM   4101 C CG  . ARG B 1 279 ? -16.33227 -18.53854 31.47627 1.000 45.21236  ? 287 ARG B CG  1 
ATOM   4102 C CD  . ARG B 1 279 ? -16.19972 -17.03437 31.67945 1.000 49.28747  ? 287 ARG B CD  1 
ATOM   4103 N NE  . ARG B 1 279 ? -17.07942 -16.55481 32.73993 1.000 57.78638  ? 287 ARG B NE  1 
ATOM   4104 C CZ  . ARG B 1 279 ? -18.25232 -15.96214 32.53780 1.000 52.33681  ? 287 ARG B CZ  1 
ATOM   4105 N NH1 . ARG B 1 279 ? -18.72178 -15.75597 31.32090 1.000 48.75749  ? 287 ARG B NH1 1 
ATOM   4106 N NH2 . ARG B 1 279 ? -18.97326 -15.57336 33.58368 1.000 50.30394  ? 287 ARG B NH2 1 
ATOM   4107 N N   . ARG B 1 280 ? -13.24552 -21.51257 32.92667 1.000 34.30040  ? 288 ARG B N   1 
ATOM   4108 C CA  . ARG B 1 280 ? -11.93010 -21.96544 33.35909 1.000 37.63187  ? 288 ARG B CA  1 
ATOM   4109 C C   . ARG B 1 280 ? -11.43720 -23.11617 32.49769 1.000 35.85163  ? 288 ARG B C   1 
ATOM   4110 O O   . ARG B 1 280 ? -10.25037 -23.18362 32.15767 1.000 35.84432  ? 288 ARG B O   1 
ATOM   4111 C CB  . ARG B 1 280 ? -11.98937 -22.35171 34.83477 1.000 41.28492  ? 288 ARG B CB  1 
ATOM   4112 C CG  . ARG B 1 280 ? -10.98857 -23.36947 35.21475 1.000 46.10155  ? 288 ARG B CG  1 
ATOM   4113 C CD  . ARG B 1 280 ? -9.64531  -22.67383 35.39595 1.000 57.99014  ? 288 ARG B CD  1 
ATOM   4114 N NE  . ARG B 1 280 ? -8.71248  -23.45391 36.20322 1.000 61.96157  ? 288 ARG B NE  1 
ATOM   4115 C CZ  . ARG B 1 280 ? -8.65768  -23.40781 37.52950 1.000 65.70527  ? 288 ARG B CZ  1 
ATOM   4116 N NH1 . ARG B 1 280 ? -9.48580  -22.64210 38.23750 1.000 63.18559  ? 288 ARG B NH1 1 
ATOM   4117 N NH2 . ARG B 1 280 ? -7.74683  -24.13928 38.16134 1.000 67.88413  ? 288 ARG B NH2 1 
ATOM   4118 N N   . ALA B 1 281 ? -12.33933 -24.03473 32.13481 1.000 35.70295  ? 289 ALA B N   1 
ATOM   4119 C CA  . ALA B 1 281 ? -12.00589 -25.09791 31.18884 1.000 35.87296  ? 289 ALA B CA  1 
ATOM   4120 C C   . ALA B 1 281 ? -11.61167 -24.53483 29.83244 1.000 33.04003  ? 289 ALA B C   1 
ATOM   4121 O O   . ALA B 1 281 ? -10.75855 -25.09370 29.13527 1.000 32.29974  ? 289 ALA B O   1 
ATOM   4122 C CB  . ALA B 1 281 ? -13.20509 -26.03732 31.03422 1.000 36.18065  ? 289 ALA B CB  1 
ATOM   4123 N N   . CYS B 1 282 ? -12.25982 -23.45027 29.42205 1.000 36.75954  ? 290 CYS B N   1 
ATOM   4124 C CA  . CYS B 1 282 ? -11.89974 -22.80826 28.16620 1.000 32.87804  ? 290 CYS B CA  1 
ATOM   4125 C C   . CYS B 1 282 ? -10.48353 -22.26091 28.22101 1.000 33.51168  ? 290 CYS B C   1 
ATOM   4126 O O   . CYS B 1 282 ? -9.71586  -22.38013 27.26066 1.000 36.01539  ? 290 CYS B O   1 
ATOM   4127 C CB  . CYS B 1 282 ? -12.89627 -21.69071 27.88599 1.000 34.48134  ? 290 CYS B CB  1 
ATOM   4128 S SG  . CYS B 1 282 ? -14.35360 -22.34168 27.07261 1.000 30.78950  ? 290 CYS B SG  1 
ATOM   4129 N N   . GLU B 1 283 ? -10.13094 -21.63747 29.33474 1.000 32.81170  ? 291 GLU B N   1 
ATOM   4130 C CA  . GLU B 1 283 ? -8.80050  -21.06870 29.45137 1.000 36.50064  ? 291 GLU B CA  1 
ATOM   4131 C C   . GLU B 1 283 ? -7.73875  -22.16543 29.49527 1.000 36.24364  ? 291 GLU B C   1 
ATOM   4132 O O   . GLU B 1 283 ? -6.71206  -22.07096 28.81261 1.000 35.33076  ? 291 GLU B O   1 
ATOM   4133 C CB  . GLU B 1 283 ? -8.72088  -20.19450 30.69662 1.000 37.01199  ? 291 GLU B CB  1 
ATOM   4134 C CG  . GLU B 1 283 ? -7.39875  -19.44185 30.79531 1.000 45.21507  ? 291 GLU B CG  1 
ATOM   4135 C CD  . GLU B 1 283 ? -7.40105  -18.35200 31.85391 1.000 56.61989  ? 291 GLU B CD  1 
ATOM   4136 O OE1 . GLU B 1 283 ? -8.44114  -17.68272 32.02583 1.000 58.16208  ? 291 GLU B OE1 1 
ATOM   4137 O OE2 . GLU B 1 283 ? -6.33529  -18.14734 32.49087 1.000 62.77032  ? 291 GLU B OE2 1 
ATOM   4138 N N   . VAL B 1 284 ? -7.99245  -23.24223 30.24106 1.000 33.43802  ? 292 VAL B N   1 
ATOM   4139 C CA  . VAL B 1 284 ? -7.01938  -24.33148 30.28862 1.000 36.27398  ? 292 VAL B CA  1 
ATOM   4140 C C   . VAL B 1 284 ? -6.78499  -24.89623 28.89395 1.000 34.77853  ? 292 VAL B C   1 
ATOM   4141 O O   . VAL B 1 284 ? -5.64431  -25.19587 28.51298 1.000 37.44446  ? 292 VAL B O   1 
ATOM   4142 C CB  . VAL B 1 284 ? -7.45913  -25.40543 31.30049 1.000 33.07384  ? 292 VAL B CB  1 
ATOM   4143 C CG1 . VAL B 1 284 ? -6.71011  -26.72552 31.06424 1.000 33.85095  ? 292 VAL B CG1 1 
ATOM   4144 C CG2 . VAL B 1 284 ? -7.19743  -24.90394 32.71657 1.000 28.55971  ? 292 VAL B CG2 1 
ATOM   4145 N N   . LEU B 1 285 ? -7.84308  -25.01216 28.09177 1.000 34.33002  ? 293 LEU B N   1 
ATOM   4146 C CA  . LEU B 1 285 ? -7.65893  -25.51550 26.73326 1.000 34.87216  ? 293 LEU B CA  1 
ATOM   4147 C C   . LEU B 1 285 ? -6.73285  -24.60808 25.91822 1.000 36.89591  ? 293 LEU B C   1 
ATOM   4148 O O   . LEU B 1 285 ? -5.89419  -25.10121 25.15707 1.000 37.57986  ? 293 LEU B O   1 
ATOM   4149 C CB  . LEU B 1 285 ? -9.01020  -25.67131 26.03766 1.000 32.11412  ? 293 LEU B CB  1 
ATOM   4150 C CG  . LEU B 1 285 ? -8.98828  -26.12465 24.57803 1.000 30.19445  ? 293 LEU B CG  1 
ATOM   4151 C CD1 . LEU B 1 285 ? -8.55480  -27.57406 24.47988 1.000 34.02119  ? 293 LEU B CD1 1 
ATOM   4152 C CD2 . LEU B 1 285 ? -10.34632 -25.95400 23.91597 1.000 34.04999  ? 293 LEU B CD2 1 
ATOM   4153 N N   . THR B 1 286 ? -6.84831  -23.27686 26.06931 1.000 35.95787  ? 294 THR B N   1 
ATOM   4154 C CA  . THR B 1 286 ? -5.92814  -22.41713 25.32924 1.000 35.11600  ? 294 THR B CA  1 
ATOM   4155 C C   . THR B 1 286 ? -4.49286  -22.61809 25.79529 1.000 35.09502  ? 294 THR B C   1 
ATOM   4156 O O   . THR B 1 286 ? -3.56974  -22.55111 24.97646 1.000 33.27395  ? 294 THR B O   1 
ATOM   4157 C CB  . THR B 1 286 ? -6.31434  -20.92452 25.43345 1.000 36.81112  ? 294 THR B CB  1 
ATOM   4158 O OG1 . THR B 1 286 ? -6.03112  -20.40175 26.74590 1.000 38.34762  ? 294 THR B OG1 1 
ATOM   4159 C CG2 . THR B 1 286 ? -7.80214  -20.71653 25.09134 1.000 34.95471  ? 294 THR B CG2 1 
ATOM   4160 N N   . GLN B 1 287 ? -4.28872  -22.88872 27.08914 1.000 35.67817  ? 295 GLN B N   1 
ATOM   4161 C CA  . GLN B 1 287 ? -2.94505  -23.20713 27.56860 1.000 36.85395  ? 295 GLN B CA  1 
ATOM   4162 C C   . GLN B 1 287 ? -2.47250  -24.54694 27.01860 1.000 39.64038  ? 295 GLN B C   1 
ATOM   4163 O O   . GLN B 1 287 ? -1.31699  -24.67446 26.58842 1.000 42.05407  ? 295 GLN B O   1 
ATOM   4164 C CB  . GLN B 1 287 ? -2.90287  -23.22278 29.10387 1.000 38.94738  ? 295 GLN B CB  1 
ATOM   4165 C CG  . GLN B 1 287 ? -3.08752  -21.84637 29.78300 1.000 39.25124  ? 295 GLN B CG  1 
ATOM   4166 C CD  . GLN B 1 287 ? -3.54951  -21.95570 31.24368 1.000 47.84938  ? 295 GLN B CD  1 
ATOM   4167 O OE1 . GLN B 1 287 ? -3.68504  -23.05343 31.79049 1.000 50.35387  ? 295 GLN B OE1 1 
ATOM   4168 N NE2 . GLN B 1 287 ? -3.81659  -20.81414 31.86776 1.000 58.19670  ? 295 GLN B NE2 1 
ATOM   4169 N N   . LEU B 1 288 ? -3.34163  -25.56471 27.03095 1.000 33.55119  ? 296 LEU B N   1 
ATOM   4170 C CA  . LEU B 1 288 ? -2.95140  -26.85209 26.46108 1.000 37.93449  ? 296 LEU B CA  1 
ATOM   4171 C C   . LEU B 1 288 ? -2.62379  -26.69966 24.98809 1.000 37.44123  ? 296 LEU B C   1 
ATOM   4172 O O   . LEU B 1 288 ? -1.61722  -27.23366 24.51554 1.000 38.91982  ? 296 LEU B O   1 
ATOM   4173 C CB  . LEU B 1 288 ? -4.05575  -27.91257 26.65833 1.000 36.83378  ? 296 LEU B CB  1 
ATOM   4174 C CG  . LEU B 1 288 ? -4.45488  -28.21010 28.11774 1.000 35.64624  ? 296 LEU B CG  1 
ATOM   4175 C CD1 . LEU B 1 288 ? -5.63596  -29.18452 28.26535 1.000 36.07803  ? 296 LEU B CD1 1 
ATOM   4176 C CD2 . LEU B 1 288 ? -3.24007  -28.71183 28.87670 1.000 36.63337  ? 296 LEU B CD2 1 
ATOM   4177 N N   . LEU B 1 289 ? -3.42905  -25.92727 24.25451 1.000 37.53560  ? 297 LEU B N   1 
ATOM   4178 C CA  . LEU B 1 289 ? -3.16111  -25.76363 22.82923 1.000 38.95829  ? 297 LEU B CA  1 
ATOM   4179 C C   . LEU B 1 289 ? -1.84065  -25.03099 22.58674 1.000 40.85175  ? 297 LEU B C   1 
ATOM   4180 O O   . LEU B 1 289 ? -1.11693  -25.35695 21.63932 1.000 43.38571  ? 297 LEU B O   1 
ATOM   4181 C CB  . LEU B 1 289 ? -4.31775  -25.03269 22.15695 1.000 34.46310  ? 297 LEU B CB  1 
ATOM   4182 C CG  . LEU B 1 289 ? -5.65658  -25.77594 22.11000 1.000 40.09559  ? 297 LEU B CG  1 
ATOM   4183 C CD1 . LEU B 1 289 ? -6.73932  -24.88492 21.49996 1.000 34.80775  ? 297 LEU B CD1 1 
ATOM   4184 C CD2 . LEU B 1 289 ? -5.53001  -27.07842 21.33555 1.000 36.49193  ? 297 LEU B CD2 1 
ATOM   4185 N N   . ALA B 1 290 ? -1.49817  -24.05636 23.43959 1.000 37.71628  ? 298 ALA B N   1 
ATOM   4186 C CA  . ALA B 1 290 ? -0.22994  -23.34402 23.28048 1.000 45.65528  ? 298 ALA B CA  1 
ATOM   4187 C C   . ALA B 1 290 ? 0.96740   -24.28781 23.43324 1.000 50.27389  ? 298 ALA B C   1 
ATOM   4188 O O   . ALA B 1 290 ? 1.96531   -24.15263 22.70931 1.000 50.03149  ? 298 ALA B O   1 
ATOM   4189 C CB  . ALA B 1 290 ? -0.14523  -22.19222 24.27851 1.000 40.95763  ? 298 ALA B CB  1 
ATOM   4190 N N   . LEU B 1 291 ? 0.88555   -25.26397 24.35107 1.000 45.44512  ? 299 LEU B N   1 
ATOM   4191 C CA  . LEU B 1 291 ? 1.94809   -26.26921 24.43324 1.000 50.45732  ? 299 LEU B CA  1 
ATOM   4192 C C   . LEU B 1 291 ? 2.07435   -27.05267 23.13171 1.000 55.24165  ? 299 LEU B C   1 
ATOM   4193 O O   . LEU B 1 291 ? 3.18351   -27.25635 22.62135 1.000 52.72736  ? 299 LEU B O   1 
ATOM   4194 C CB  . LEU B 1 291 ? 1.71394   -27.23288 25.60082 1.000 52.28717  ? 299 LEU B CB  1 
ATOM   4195 C CG  . LEU B 1 291 ? 2.47589   -27.08980 26.92923 1.000 59.21148  ? 299 LEU B CG  1 
ATOM   4196 C CD1 . LEU B 1 291 ? 2.37357   -25.70965 27.56899 1.000 60.09532  ? 299 LEU B CD1 1 
ATOM   4197 C CD2 . LEU B 1 291 ? 1.99393   -28.17192 27.88759 1.000 58.53876  ? 299 LEU B CD2 1 
ATOM   4198 N N   . GLN B 1 292 ? 0.94282   -27.51714 22.58811 1.000 48.95253  ? 300 GLN B N   1 
ATOM   4199 C CA  . GLN B 1 292 ? 0.98380   -28.34196 21.38461 1.000 50.96535  ? 300 GLN B CA  1 
ATOM   4200 C C   . GLN B 1 292 ? 1.49439   -27.57636 20.16717 1.000 55.47683  ? 300 GLN B C   1 
ATOM   4201 O O   . GLN B 1 292 ? 2.13404   -28.17040 19.29376 1.000 61.03969  ? 300 GLN B O   1 
ATOM   4202 C CB  . GLN B 1 292 ? -0.39758  -28.90436 21.09668 1.000 46.89802  ? 300 GLN B CB  1 
ATOM   4203 C CG  . GLN B 1 292 ? -0.44596  -29.83084 19.92896 1.000 49.41797  ? 300 GLN B CG  1 
ATOM   4204 C CD  . GLN B 1 292 ? 0.47124   -31.01570 20.11537 1.000 57.79907  ? 300 GLN B CD  1 
ATOM   4205 O OE1 . GLN B 1 292 ? 1.42481   -31.20520 19.35346 1.000 62.01502  ? 300 GLN B OE1 1 
ATOM   4206 N NE2 . GLN B 1 292 ? 0.19145   -31.82508 21.13864 1.000 56.44905  ? 300 GLN B NE2 1 
ATOM   4207 N N   . LEU B 1 293 ? 1.22877   -26.26853 20.08588 1.000 54.19265  ? 301 LEU B N   1 
ATOM   4208 C CA  . LEU B 1 293 ? 1.67110   -25.49253 18.92970 1.000 55.98593  ? 301 LEU B CA  1 
ATOM   4209 C C   . LEU B 1 293 ? 3.17436   -25.21819 18.95714 1.000 60.09858  ? 301 LEU B C   1 
ATOM   4210 O O   . LEU B 1 293 ? 3.78213   -25.02435 17.89658 1.000 63.15662  ? 301 LEU B O   1 
ATOM   4211 C CB  . LEU B 1 293 ? 0.89590   -24.17803 18.85753 1.000 52.86876  ? 301 LEU B CB  1 
ATOM   4212 C CG  . LEU B 1 293 ? -0.60543  -24.25625 18.57533 1.000 48.73924  ? 301 LEU B CG  1 
ATOM   4213 C CD1 . LEU B 1 293 ? -1.23841  -22.87660 18.69073 1.000 44.00108  ? 301 LEU B CD1 1 
ATOM   4214 C CD2 . LEU B 1 293 ? -0.86238  -24.84857 17.19611 1.000 47.54878  ? 301 LEU B CD2 1 
ATOM   4215 N N   . SER B 1 294 ? 3.78135   -25.15544 20.14454 1.000 59.01013  ? 302 SER B N   1 
ATOM   4216 C CA  . SER B 1 294 ? 5.21650   -24.90006 20.27548 1.000 65.37184  ? 302 SER B CA  1 
ATOM   4217 C C   . SER B 1 294 ? 6.03607   -26.18309 20.34153 1.000 75.55677  ? 302 SER B C   1 
ATOM   4218 O O   . SER B 1 294 ? 7.00255   -26.35364 19.58867 1.000 79.67905  ? 302 SER B O   1 
ATOM   4219 C CB  . SER B 1 294 ? 5.49691   -24.06711 21.52631 1.000 62.24073  ? 302 SER B CB  1 
ATOM   4220 O OG  . SER B 1 294 ? 4.62387   -22.95301 21.59326 1.000 57.80333  ? 302 SER B OG  1 
ATOM   4221 N N   . ALA B 1 295 ? 5.65789   -27.09398 21.23918 1.000 75.76778  ? 303 ALA B N   1 
ATOM   4222 C CA  . ALA B 1 295 ? 6.39228   -28.33850 21.40518 1.000 81.50271  ? 303 ALA B CA  1 
ATOM   4223 C C   . ALA B 1 295 ? 6.38374   -29.18691 20.14188 1.000 88.27051  ? 303 ALA B C   1 
ATOM   4224 O O   . ALA B 1 295 ? 7.19353   -30.11968 20.03613 1.000 90.39969  ? 303 ALA B O   1 
ATOM   4225 C CB  . ALA B 1 295 ? 5.80466   -29.12890 22.57954 1.000 79.94938  ? 303 ALA B CB  1 
ATOM   4226 N N   . GLU B 1 296 ? 5.50512   -28.87382 19.17985 1.000 84.81132  ? 304 GLU B N   1 
ATOM   4227 C CA  . GLU B 1 296 ? 5.48824   -29.59103 17.91109 1.000 88.50685  ? 304 GLU B CA  1 
ATOM   4228 C C   . GLU B 1 296 ? 6.81443   -29.46746 17.17639 1.000 97.00683  ? 304 GLU B C   1 
ATOM   4229 O O   . GLU B 1 296 ? 7.14659   -30.33482 16.35641 1.000 100.61785 ? 304 GLU B O   1 
ATOM   4230 C CB  . GLU B 1 296 ? 4.36074   -29.06226 17.01765 1.000 82.87692  ? 304 GLU B CB  1 
ATOM   4231 C CG  . GLU B 1 296 ? 3.85677   -30.07518 16.00205 1.000 93.41707  ? 304 GLU B CG  1 
ATOM   4232 C CD  . GLU B 1 296 ? 4.37683   -29.80765 14.59702 1.000 97.94029  ? 304 GLU B CD  1 
ATOM   4233 O OE1 . GLU B 1 296 ? 4.81728   -28.66668 14.33153 1.000 93.83924  ? 304 GLU B OE1 1 
ATOM   4234 O OE2 . GLU B 1 296 ? 4.35834   -30.74533 13.76580 1.000 99.55224  ? 304 GLU B OE2 1 
ATOM   4235 N N   . GLU B 1 297 ? 7.58667   -28.42034 17.46951 1.000 96.35163  ? 305 GLU B N   1 
ATOM   4236 C CA  . GLU B 1 297 ? 8.91611   -28.26633 16.89940 1.000 98.57757  ? 305 GLU B CA  1 
ATOM   4237 C C   . GLU B 1 297 ? 9.97051   -28.76946 17.87995 1.000 103.18417 ? 305 GLU B C   1 
ATOM   4238 O O   . GLU B 1 297 ? 10.49068  -29.87889 17.71786 1.000 105.69795 ? 305 GLU B O   1 
ATOM   4239 C CB  . GLU B 1 297 ? 9.16109   -26.79961 16.52098 1.000 98.47651  ? 305 GLU B CB  1 
ATOM   4240 C CG  . GLU B 1 297 ? 8.24855   -26.28215 15.39950 1.000 95.27649  ? 305 GLU B CG  1 
ATOM   4241 C CD  . GLU B 1 297 ? 6.96152   -25.63893 15.91751 1.000 88.02130  ? 305 GLU B CD  1 
ATOM   4242 O OE1 . GLU B 1 297 ? 7.04972   -24.67110 16.71050 1.000 78.06885  ? 305 GLU B OE1 1 
ATOM   4243 O OE2 . GLU B 1 297 ? 5.86298   -26.10353 15.52895 1.000 87.89890  ? 305 GLU B OE2 1 
ATOM   4244 N N   . ARG B 1 298 ? 10.27525  -27.97860 18.90812 1.000 104.39028 ? 306 ARG B N   1 
ATOM   4245 C CA  . ARG B 1 298 ? 11.24966  -28.38116 19.92298 1.000 107.28898 ? 306 ARG B CA  1 
ATOM   4246 C C   . ARG B 1 298 ? 10.57137  -29.16375 21.03811 1.000 104.43406 ? 306 ARG B C   1 
ATOM   4247 O O   . ARG B 1 298 ? 9.63081   -28.67442 21.66255 1.000 104.52218 ? 306 ARG B O   1 
ATOM   4248 C CB  . ARG B 1 298 ? 11.97336  -27.15986 20.50381 1.000 112.47573 ? 306 ARG B CB  1 
ATOM   4249 C CG  . ARG B 1 298 ? 13.19999  -27.50428 21.34700 1.000 114.39898 ? 306 ARG B CG  1 
ATOM   4250 C CD  . ARG B 1 298 ? 13.56193  -26.37472 22.30913 1.000 119.29676 ? 306 ARG B CD  1 
ATOM   4251 N NE  . ARG B 1 298 ? 12.50930  -26.11322 23.28601 1.000 123.94513 ? 306 ARG B NE  1 
ATOM   4252 C CZ  . ARG B 1 298 ? 12.34784  -26.78712 24.41772 1.000 122.11540 ? 306 ARG B CZ  1 
ATOM   4253 N NH1 . ARG B 1 298 ? 13.16095  -27.77567 24.75580 1.000 119.98155 ? 306 ARG B NH1 1 
ATOM   4254 N NH2 . ARG B 1 298 ? 11.34545  -26.46046 25.23073 1.000 119.65400 ? 306 ARG B NH2 1 
HETATM 4255 C C1A . EL5 C 2 .   ? 12.98306  -4.68961  11.70820 1.000 52.55895  ? 401 EL5 A C1A 1 
HETATM 4256 C C1B . EL5 C 2 .   ? 12.81858  -4.33879  16.11894 1.000 35.10307  ? 401 EL5 A C1B 1 
HETATM 4257 O O1B . EL5 C 2 .   ? 13.96503  -1.17746  22.15877 1.000 40.58690  ? 401 EL5 A O1B 1 
HETATM 4258 C C1C . EL5 C 2 .   ? 13.54339  -0.03513  15.56285 1.000 35.00005  ? 401 EL5 A C1C 1 
HETATM 4259 O O1C . EL5 C 2 .   ? 16.51063  3.20068   17.09671 1.000 40.82248  ? 401 EL5 A O1C 1 
HETATM 4260 C C1D . EL5 C 2 .   ? 15.54773  -1.19054  11.93981 1.000 47.08227  ? 401 EL5 A C1D 1 
HETATM 4261 C C2A . EL5 C 2 .   ? 12.70764  -6.15582  11.66521 1.000 55.63774  ? 401 EL5 A C2A 1 
HETATM 4262 C C2B . EL5 C 2 .   ? 12.63883  -4.38988  17.57199 1.000 35.80392  ? 401 EL5 A C2B 1 
HETATM 4263 O O2B . EL5 C 2 .   ? 13.57838  -3.32584  22.39258 1.000 44.71328  ? 401 EL5 A O2B 1 
HETATM 4264 C C2C . EL5 C 2 .   ? 13.55641  1.30767   15.24300 1.000 39.84909  ? 401 EL5 A C2C 1 
HETATM 4265 O O2C . EL5 C 2 .   ? 15.22064  4.03029   15.56216 1.000 52.74956  ? 401 EL5 A O2C 1 
HETATM 4266 C C2D . EL5 C 2 .   ? 15.96610  -1.73395  10.61619 1.000 49.59304  ? 401 EL5 A C2D 1 
HETATM 4267 C C3A . EL5 C 2 .   ? 12.58879  -6.64143  13.11153 1.000 52.43383  ? 401 EL5 A C3A 1 
HETATM 4268 C C3B . EL5 C 2 .   ? 12.72356  -3.03989  18.05996 1.000 36.27975  ? 401 EL5 A C3B 1 
HETATM 4269 C C3C . EL5 C 2 .   ? 14.08614  1.44800   14.00786 1.000 42.39742  ? 401 EL5 A C3C 1 
HETATM 4270 C C3D . EL5 C 2 .   ? 16.43090  -3.07742  10.76145 1.000 52.53796  ? 401 EL5 A C3D 1 
HETATM 4271 C C4A . EL5 C 2 .   ? 12.79302  -5.49685  14.02766 1.000 44.76364  ? 401 EL5 A C4A 1 
HETATM 4272 C C4B . EL5 C 2 .   ? 12.94511  -2.06265  16.86833 1.000 38.25090  ? 401 EL5 A C4B 1 
HETATM 4273 C C4C . EL5 C 2 .   ? 14.40621  0.23037   13.54095 1.000 44.86918  ? 401 EL5 A C4C 1 
HETATM 4274 C C4D . EL5 C 2 .   ? 16.37257  -3.51299  12.19808 1.000 48.61579  ? 401 EL5 A C4D 1 
HETATM 4275 C CAA . EL5 C 2 .   ? 12.30640  -7.85216  13.55642 1.000 56.42367  ? 401 EL5 A CAA 1 
HETATM 4276 C CAB . EL5 C 2 .   ? 12.58972  -2.76128  19.55530 1.000 40.37478  ? 401 EL5 A CAB 1 
HETATM 4277 C CAC . EL5 C 2 .   ? 13.07007  2.45980   16.10668 1.000 40.26326  ? 401 EL5 A CAC 1 
HETATM 4278 C CAD . EL5 C 2 .   ? 16.94137  -3.94440  9.60733  1.000 54.44035  ? 401 EL5 A CAD 1 
HETATM 4279 C CBA . EL5 C 2 .   ? 13.13113  -9.05881  13.27336 1.000 71.19315  ? 401 EL5 A CBA 1 
HETATM 4280 C CBB . EL5 C 2 .   ? 13.97274  -2.59612  20.16336 1.000 40.07530  ? 401 EL5 A CBB 1 
HETATM 4281 C CBC . EL5 C 2 .   ? 14.11368  2.65058   17.19896 1.000 41.84993  ? 401 EL5 A CBC 1 
HETATM 4282 C CBD . EL5 C 2 .   ? 17.72157  -4.97613  9.84452  1.000 52.77443  ? 401 EL5 A CBD 1 
HETATM 4283 C CGB . EL5 C 2 .   ? 13.82110  -2.34191  21.65804 1.000 43.17456  ? 401 EL5 A CGB 1 
HETATM 4284 C CGC . EL5 C 2 .   ? 15.35572  3.31820   16.59033 1.000 46.61940  ? 401 EL5 A CGC 1 
HETATM 4285 C CHB . EL5 C 2 .   ? 12.76642  -5.59300  15.31196 1.000 39.86685  ? 401 EL5 A CHB 1 
HETATM 4286 C CHC . EL5 C 2 .   ? 13.07217  -0.74147  16.84874 1.000 36.26612  ? 401 EL5 A CHC 1 
HETATM 4287 C CHD . EL5 C 2 .   ? 15.05095  -0.00634  12.17205 1.000 45.49287  ? 401 EL5 A CHD 1 
HETATM 4288 C CMA . EL5 C 2 .   ? 13.93083  -6.75502  10.97845 1.000 51.41414  ? 401 EL5 A CMA 1 
HETATM 4289 C CMB . EL5 C 2 .   ? 12.42249  -5.64694  18.41774 1.000 38.02059  ? 401 EL5 A CMB 1 
HETATM 4290 C CMC . EL5 C 2 .   ? 14.31956  2.69456   13.16316 1.000 51.73905  ? 401 EL5 A CMC 1 
HETATM 4291 C CMD . EL5 C 2 .   ? 15.88273  -0.96533  9.29723  1.000 46.14305  ? 401 EL5 A CMD 1 
HETATM 4292 N NA  . EL5 C 2 .   ? 13.04761  -4.25115  13.18151 1.000 45.32183  ? 401 EL5 A NA  1 
HETATM 4293 O OA  . EL5 C 2 .   ? 13.14518  -4.01161  10.75555 1.000 54.35747  ? 401 EL5 A OA  1 
HETATM 4294 N NB  . EL5 C 2 .   ? 13.02277  -2.95546  15.64993 1.000 34.18959  ? 401 EL5 A NB  1 
HETATM 4295 N NC  . EL5 C 2 .   ? 14.06428  -0.66823  14.49548 1.000 40.59502  ? 401 EL5 A NC  1 
HETATM 4296 N ND  . EL5 C 2 .   ? 15.79828  -2.31147  12.97880 1.000 45.04831  ? 401 EL5 A ND  1 
HETATM 4297 O OD  . EL5 C 2 .   ? 16.69997  -4.56472  12.64734 1.000 46.42442  ? 401 EL5 A OD  1 
HETATM 4298 C C1A . EL5 D 2 .   ? -12.57195 -4.00026  11.92258 1.000 48.94366  ? 401 EL5 B C1A 1 
HETATM 4299 C C1B . EL5 D 2 .   ? -12.38138 -4.36120  16.33773 1.000 37.16544  ? 401 EL5 B C1B 1 
HETATM 4300 O O1B . EL5 D 2 .   ? -13.59644 -7.75949  22.15524 1.000 37.57111  ? 401 EL5 B O1B 1 
HETATM 4301 C C1C . EL5 D 2 .   ? -13.18385 -8.61582  15.57061 1.000 38.78178  ? 401 EL5 B C1C 1 
HETATM 4302 O O1C . EL5 D 2 .   ? -16.09444 -11.87124 17.16102 1.000 37.01737  ? 401 EL5 B O1C 1 
HETATM 4303 C C1D . EL5 D 2 .   ? -15.15608 -7.27392  11.97499 1.000 45.28577  ? 401 EL5 B C1D 1 
HETATM 4304 C C2A . EL5 D 2 .   ? -12.33351 -2.53398  11.85614 1.000 54.55666  ? 401 EL5 B C2A 1 
HETATM 4305 C C2B . EL5 D 2 .   ? -12.25147 -4.40631  17.79480 1.000 33.24422  ? 401 EL5 B C2B 1 
HETATM 4306 O O2B . EL5 D 2 .   ? -13.35995 -5.59336  22.32339 1.000 34.34577  ? 401 EL5 B O2B 1 
HETATM 4307 C C2C . EL5 D 2 .   ? -13.15119 -9.93693  15.18284 1.000 40.00783  ? 401 EL5 B C2C 1 
HETATM 4308 O O2C . EL5 D 2 .   ? -14.96723 -12.67337 15.49498 1.000 43.24087  ? 401 EL5 B O2C 1 
HETATM 4309 C C2D . EL5 D 2 .   ? -15.62485 -6.68459  10.68629 1.000 48.87639  ? 401 EL5 B C2D 1 
HETATM 4310 C C3A . EL5 D 2 .   ? -12.19853 -2.03723  13.29669 1.000 53.60127  ? 401 EL5 B C3A 1 
HETATM 4311 C C3B . EL5 D 2 .   ? -12.38041 -5.80719  18.19023 1.000 35.68155  ? 401 EL5 B C3B 1 
HETATM 4312 C C3C . EL5 D 2 .   ? -13.66741 -10.03913 13.93205 1.000 44.32110  ? 401 EL5 B C3C 1 
HETATM 4313 C C3D . EL5 D 2 .   ? -16.11695 -5.36947  10.89776 1.000 49.57580  ? 401 EL5 B C3D 1 
HETATM 4314 C C4A . EL5 D 2 .   ? -12.37030 -3.16736  14.23629 1.000 43.46731  ? 401 EL5 B C4A 1 
HETATM 4315 C C4B . EL5 D 2 .   ? -12.57965 -6.69167  16.96833 1.000 34.43098  ? 401 EL5 B C4B 1 
HETATM 4316 C C4C . EL5 D 2 .   ? -14.02084 -8.79108  13.52429 1.000 44.05698  ? 401 EL5 B C4C 1 
HETATM 4317 C C4D . EL5 D 2 .   ? -16.01815 -4.98954  12.33808 1.000 48.85588  ? 401 EL5 B C4D 1 
HETATM 4318 C CAA . EL5 D 2 .   ? -11.94094 -0.81438  13.70864 1.000 55.76344  ? 401 EL5 B CAA 1 
HETATM 4319 C CAB . EL5 D 2 .   ? -12.27879 -6.23992  19.63928 1.000 38.15261  ? 401 EL5 B CAB 1 
HETATM 4320 C CAC . EL5 D 2 .   ? -12.65428 -11.08913 16.02757 1.000 39.20408  ? 401 EL5 B CAC 1 
HETATM 4321 C CAD . EL5 D 2 .   ? -16.67879 -4.46622  9.79864  1.000 54.21156  ? 401 EL5 B CAD 1 
HETATM 4322 C CBA . EL5 D 2 .   ? -12.80891 0.36420   13.41859 1.000 66.46259  ? 401 EL5 B CBA 1 
HETATM 4323 C CBB . EL5 D 2 .   ? -13.69663 -6.39448  20.13514 1.000 32.75357  ? 401 EL5 B CBB 1 
HETATM 4324 C CBC . EL5 D 2 .   ? -13.72102 -11.33374 17.10596 1.000 38.74198  ? 401 EL5 B CBC 1 
HETATM 4325 C CBD . EL5 D 2 .   ? -17.48938 -3.47301  10.10730 1.000 51.59139  ? 401 EL5 B CBD 1 
HETATM 4326 C CGB . EL5 D 2 .   ? -13.54524 -6.61508  21.62432 1.000 35.62920  ? 401 EL5 B CGB 1 
HETATM 4327 C CGC . EL5 D 2 .   ? -14.99222 -12.00084 16.55469 1.000 41.43297  ? 401 EL5 B CGC 1 
HETATM 4328 C CHB . EL5 D 2 .   ? -12.33275 -3.08610  15.53280 1.000 41.73350  ? 401 EL5 B CHB 1 
HETATM 4329 C CHC . EL5 D 2 .   ? -12.72196 -8.00014  16.89880 1.000 33.83344  ? 401 EL5 B CHC 1 
HETATM 4330 C CHD . EL5 D 2 .   ? -14.64593 -8.46148  12.17103 1.000 46.59830  ? 401 EL5 B CHD 1 
HETATM 4331 C CMA . EL5 D 2 .   ? -13.63245 -1.99650  11.24218 1.000 50.69708  ? 401 EL5 B CMA 1 
HETATM 4332 C CMB . EL5 D 2 .   ? -12.04952 -3.19738  18.70870 1.000 35.01029  ? 401 EL5 B CMB 1 
HETATM 4333 C CMC . EL5 D 2 .   ? -13.83926 -11.28868 13.06311 1.000 48.02313  ? 401 EL5 B CMC 1 
HETATM 4334 C CMD . EL5 D 2 .   ? -15.58122 -7.38167  9.32959  1.000 47.20835  ? 401 EL5 B CMD 1 
HETATM 4335 N NA  . EL5 D 2 .   ? -12.62151 -4.41482  13.38884 1.000 45.59311  ? 401 EL5 B NA  1 
HETATM 4336 O OA  . EL5 D 2 .   ? -12.73549 -4.69979  10.99699 1.000 52.75694  ? 401 EL5 B OA  1 
HETATM 4337 N NB  . EL5 D 2 .   ? -12.59008 -5.71881  15.81809 1.000 34.95748  ? 401 EL5 B NB  1 
HETATM 4338 N NC  . EL5 D 2 .   ? -13.71353 -7.93049  14.52987 1.000 41.51505  ? 401 EL5 B NC  1 
HETATM 4339 N ND  . EL5 D 2 .   ? -15.40830 -6.20826  13.04859 1.000 45.61562  ? 401 EL5 B ND  1 
HETATM 4340 O OD  . EL5 D 2 .   ? -16.34937 -3.96311  12.84201 1.000 49.96188  ? 401 EL5 B OD  1 
HETATM 4341 O O   . HOH E 3 .   ? -3.42859  12.99245  22.82702 1.000 48.27507  ? 501 HOH A O   1 
HETATM 4342 O O   . HOH E 3 .   ? 15.01963  -3.63159  23.90094 1.000 45.51724  ? 502 HOH A O   1 
HETATM 4343 O O   . HOH E 3 .   ? 7.15759   12.32987  34.66975 1.000 50.32450  ? 503 HOH A O   1 
HETATM 4344 O O   . HOH E 3 .   ? 18.68434  2.49517   33.01951 1.000 52.16412  ? 504 HOH A O   1 
HETATM 4345 O O   . HOH E 3 .   ? 19.45783  19.70467  34.03157 1.000 49.45325  ? 505 HOH A O   1 
HETATM 4346 O O   . HOH E 3 .   ? 13.46662  -4.11972  8.60394  1.000 55.07406  ? 506 HOH A O   1 
HETATM 4347 O O   . HOH E 3 .   ? 22.87632  14.39490  31.31837 1.000 46.11976  ? 507 HOH A O   1 
HETATM 4348 O O   . HOH E 3 .   ? 11.66293  2.48566   30.12055 1.000 49.90932  ? 508 HOH A O   1 
HETATM 4349 O O   . HOH E 3 .   ? 17.06017  -14.04176 58.41462 1.000 72.05632  ? 509 HOH A O   1 
HETATM 4350 O O   . HOH E 3 .   ? -8.37552  22.41906  21.08745 1.000 83.06073  ? 510 HOH A O   1 
HETATM 4351 O O   . HOH E 3 .   ? 29.47688  -13.37820 49.58277 1.000 55.43202  ? 511 HOH A O   1 
HETATM 4352 O O   . HOH E 3 .   ? -0.31744  23.17139  17.48147 1.000 71.36930  ? 512 HOH A O   1 
HETATM 4353 O O   . HOH E 3 .   ? 16.20524  4.40256   19.04759 1.000 47.04040  ? 513 HOH A O   1 
HETATM 4354 O O   . HOH E 3 .   ? 3.00276   -12.21982 11.37657 1.000 54.91276  ? 514 HOH A O   1 
HETATM 4355 O O   . HOH E 3 .   ? 12.28692  1.82704   19.33191 1.000 46.72234  ? 515 HOH A O   1 
HETATM 4356 O O   . HOH E 3 .   ? 16.51087  -15.06431 25.50756 1.000 46.37995  ? 516 HOH A O   1 
HETATM 4357 O O   . HOH E 3 .   ? 3.58639   -7.92118  6.44527  1.000 65.95533  ? 517 HOH A O   1 
HETATM 4358 O O   . HOH E 3 .   ? 12.85433  -6.69599  24.12409 1.000 45.16673  ? 518 HOH A O   1 
HETATM 4359 O O   . HOH E 3 .   ? 10.75208  -2.63713  28.35642 1.000 45.02394  ? 519 HOH A O   1 
HETATM 4360 O O   . HOH E 3 .   ? 29.00736  -0.03133  27.94585 1.000 32.71879  ? 520 HOH A O   1 
HETATM 4361 O O   . HOH E 3 .   ? 16.91739  5.00818   13.83862 1.000 48.25981  ? 521 HOH A O   1 
HETATM 4362 O O   . HOH E 3 .   ? 2.43133   -11.39466 19.29785 1.000 49.48688  ? 522 HOH A O   1 
HETATM 4363 O O   . HOH E 3 .   ? 13.61441  -5.64696  21.64899 1.000 37.90238  ? 523 HOH A O   1 
HETATM 4364 O O   . HOH E 3 .   ? 14.27337  0.87085   20.86479 1.000 42.96771  ? 524 HOH A O   1 
HETATM 4365 O O   . HOH E 3 .   ? -2.25708  4.60299   25.80302 1.000 40.08089  ? 525 HOH A O   1 
HETATM 4366 O O   . HOH E 3 .   ? 3.28378   11.32223  24.22774 1.000 39.16953  ? 526 HOH A O   1 
HETATM 4367 O O   . HOH E 3 .   ? 16.52274  1.48928   19.40199 1.000 40.89604  ? 527 HOH A O   1 
HETATM 4368 O O   . HOH E 3 .   ? 20.80860  4.52474   32.89583 1.000 51.38336  ? 528 HOH A O   1 
HETATM 4369 O O   . HOH E 3 .   ? 11.33572  -8.99893  16.66699 1.000 56.45589  ? 529 HOH A O   1 
HETATM 4370 O O   . HOH E 3 .   ? -0.20168  15.57129  10.94621 1.000 57.21854  ? 530 HOH A O   1 
HETATM 4371 O O   . HOH E 3 .   ? 18.20463  0.34595   29.86585 1.000 39.58659  ? 531 HOH A O   1 
HETATM 4372 O O   . HOH E 3 .   ? 12.91966  -0.38076  28.56254 1.000 62.25244  ? 532 HOH A O   1 
HETATM 4373 O O   . HOH E 3 .   ? 17.86796  11.90791  7.74367  1.000 80.12317  ? 533 HOH A O   1 
HETATM 4374 O O   . HOH E 3 .   ? 25.37234  -2.33895  38.49906 1.000 52.25523  ? 534 HOH A O   1 
HETATM 4375 O O   . HOH E 3 .   ? 13.72242  24.01112  16.67898 1.000 34.00812  ? 535 HOH A O   1 
HETATM 4376 O O   . HOH E 3 .   ? 11.72283  -11.78382 29.83835 1.000 38.85793  ? 536 HOH A O   1 
HETATM 4377 O O   . HOH E 3 .   ? 2.70153   -16.60196 16.10721 1.000 56.56304  ? 537 HOH A O   1 
HETATM 4378 O O   . HOH E 3 .   ? 15.93189  3.00753   22.58401 1.000 40.42334  ? 538 HOH A O   1 
HETATM 4379 O O   . HOH E 3 .   ? 13.89277  17.81262  34.89475 1.000 40.02579  ? 539 HOH A O   1 
HETATM 4380 O O   . HOH E 3 .   ? 5.56570   -14.53791 50.83009 1.000 75.71162  ? 540 HOH A O   1 
HETATM 4381 O O   . HOH E 3 .   ? 4.38410   -7.53686  26.06361 1.000 46.19045  ? 541 HOH A O   1 
HETATM 4382 O O   . HOH E 3 .   ? 9.41453   -0.18871  29.52046 1.000 52.96543  ? 542 HOH A O   1 
HETATM 4383 O O   . HOH E 3 .   ? 26.75499  -12.44801 39.88388 1.000 42.84481  ? 543 HOH A O   1 
HETATM 4384 O O   . HOH E 3 .   ? 35.88725  0.53113   21.76539 1.000 46.59473  ? 544 HOH A O   1 
HETATM 4385 O O   . HOH E 3 .   ? 14.80293  -9.48949  28.08465 1.000 36.26799  ? 545 HOH A O   1 
HETATM 4386 O O   . HOH E 3 .   ? 22.34422  6.76708   28.11375 1.000 36.43073  ? 546 HOH A O   1 
HETATM 4387 O O   . HOH E 3 .   ? 23.35085  13.20215  28.48548 1.000 40.13290  ? 547 HOH A O   1 
HETATM 4388 O O   . HOH E 3 .   ? 21.29581  10.54416  37.51207 1.000 41.42185  ? 548 HOH A O   1 
HETATM 4389 O O   . HOH E 3 .   ? 17.96916  8.74752   4.39977  1.000 77.56711  ? 549 HOH A O   1 
HETATM 4390 O O   . HOH E 3 .   ? 26.24076  12.63741  30.89884 1.000 45.32224  ? 550 HOH A O   1 
HETATM 4391 O O   . HOH E 3 .   ? 23.31608  5.31427   31.76162 1.000 46.72853  ? 551 HOH A O   1 
HETATM 4392 O O   . HOH E 3 .   ? 0.66354   8.57737   13.29247 1.000 40.32755  ? 552 HOH A O   1 
HETATM 4393 O O   . HOH E 3 .   ? -2.17741  10.32591  24.67835 1.000 43.13462  ? 553 HOH A O   1 
HETATM 4394 O O   . HOH E 3 .   ? 9.16075   2.83166   24.78000 1.000 33.51051  ? 554 HOH A O   1 
HETATM 4395 O O   . HOH E 3 .   ? -7.97651  14.03831  14.11611 1.000 74.04374  ? 555 HOH A O   1 
HETATM 4396 O O   . HOH E 3 .   ? 29.70740  10.44298  20.07061 1.000 68.79488  ? 556 HOH A O   1 
HETATM 4397 O O   . HOH E 3 .   ? 20.25046  -8.62656  23.84372 1.000 43.44105  ? 557 HOH A O   1 
HETATM 4398 O O   . HOH E 3 .   ? 29.68402  2.41818   19.41669 1.000 40.43195  ? 558 HOH A O   1 
HETATM 4399 O O   . HOH E 3 .   ? 15.40716  3.58653   9.68187  1.000 64.09596  ? 559 HOH A O   1 
HETATM 4400 O O   . HOH E 3 .   ? 28.17903  -6.30493  28.69991 1.000 40.82426  ? 560 HOH A O   1 
HETATM 4401 O O   . HOH E 3 .   ? 22.92019  -9.04263  18.91154 1.000 40.20996  ? 561 HOH A O   1 
HETATM 4402 O O   . HOH E 3 .   ? 4.10995   -4.54162  45.91723 1.000 63.55650  ? 562 HOH A O   1 
HETATM 4403 O O   . HOH E 3 .   ? 14.55800  1.15839   29.03164 1.000 43.68447  ? 563 HOH A O   1 
HETATM 4404 O O   . HOH E 3 .   ? 24.77319  4.91572   27.78555 1.000 41.71340  ? 564 HOH A O   1 
HETATM 4405 O O   . HOH E 3 .   ? 2.03534   -8.02366  29.03886 1.000 42.90727  ? 565 HOH A O   1 
HETATM 4406 O O   . HOH E 3 .   ? 10.23767  19.07749  29.24964 1.000 39.08437  ? 566 HOH A O   1 
HETATM 4407 O O   . HOH E 3 .   ? 14.80692  17.61946  9.83041  1.000 43.16305  ? 567 HOH A O   1 
HETATM 4408 O O   . HOH E 3 .   ? 23.47602  11.75764  4.11095  1.000 83.81213  ? 568 HOH A O   1 
HETATM 4409 O O   . HOH E 3 .   ? 11.23162  -1.72477  38.02065 1.000 46.32364  ? 569 HOH A O   1 
HETATM 4410 O O   . HOH E 3 .   ? 7.48014   -6.10556  33.33878 1.000 43.03610  ? 570 HOH A O   1 
HETATM 4411 O O   . HOH E 3 .   ? 12.35027  -9.70393  27.40055 1.000 34.70087  ? 571 HOH A O   1 
HETATM 4412 O O   . HOH E 3 .   ? 23.86544  -5.40409  27.98181 1.000 33.55091  ? 572 HOH A O   1 
HETATM 4413 O O   . HOH E 3 .   ? 30.45810  -2.53995  25.36481 1.000 34.70699  ? 573 HOH A O   1 
HETATM 4414 O O   . HOH E 3 .   ? 7.42786   -0.29332  11.26844 1.000 48.43982  ? 574 HOH A O   1 
HETATM 4415 O O   . HOH E 3 .   ? 35.06018  2.22360   20.21616 1.000 45.93444  ? 575 HOH A O   1 
HETATM 4416 O O   . HOH E 3 .   ? 23.01146  17.08170  33.32683 1.000 54.80485  ? 576 HOH A O   1 
HETATM 4417 O O   . HOH E 3 .   ? 2.31025   -10.67592 32.41320 1.000 46.90242  ? 577 HOH A O   1 
HETATM 4418 O O   . HOH E 3 .   ? -3.18694  -0.38311  6.56163  1.000 65.25106  ? 578 HOH A O   1 
HETATM 4419 O O   . HOH E 3 .   ? 30.05417  11.71230  24.23903 1.000 49.13453  ? 579 HOH A O   1 
HETATM 4420 O O   . HOH E 3 .   ? 1.24648   -0.25896  16.61941 1.000 38.45247  ? 580 HOH A O   1 
HETATM 4421 O O   . HOH E 3 .   ? 28.39715  0.11788   18.46014 1.000 41.99397  ? 581 HOH A O   1 
HETATM 4422 O O   . HOH E 3 .   ? 4.36254   -22.69598 30.21370 1.000 63.81841  ? 582 HOH A O   1 
HETATM 4423 O O   . HOH E 3 .   ? 3.95604   5.45480   25.90530 1.000 42.76584  ? 583 HOH A O   1 
HETATM 4424 O O   . HOH E 3 .   ? 22.94778  -1.78600  26.88569 1.000 32.75124  ? 584 HOH A O   1 
HETATM 4425 O O   . HOH E 3 .   ? 30.52929  4.00824   12.62282 1.000 60.73433  ? 585 HOH A O   1 
HETATM 4426 O O   . HOH E 3 .   ? 27.00828  4.85434   40.09545 1.000 44.52102  ? 586 HOH A O   1 
HETATM 4427 O O   . HOH E 3 .   ? 26.44049  15.21337  20.54879 1.000 50.61810  ? 587 HOH A O   1 
HETATM 4428 O O   . HOH E 3 .   ? 3.21898   -2.00994  38.07379 1.000 51.73717  ? 588 HOH A O   1 
HETATM 4429 O O   . HOH E 3 .   ? 24.85107  -17.90413 41.21785 1.000 54.52629  ? 589 HOH A O   1 
HETATM 4430 O O   . HOH E 3 .   ? 4.44240   7.55372   41.98989 1.000 64.22215  ? 590 HOH A O   1 
HETATM 4431 O O   . HOH E 3 .   ? 28.17166  11.42328  39.86780 1.000 57.16165  ? 591 HOH A O   1 
HETATM 4432 O O   . HOH E 3 .   ? 16.31519  -18.54233 52.29467 1.000 62.42193  ? 592 HOH A O   1 
HETATM 4433 O O   . HOH E 3 .   ? 9.98079   4.51864   23.84524 1.000 34.88224  ? 593 HOH A O   1 
HETATM 4434 O O   . HOH E 3 .   ? 3.82778   9.26498   8.57662  1.000 50.68921  ? 594 HOH A O   1 
HETATM 4435 O O   . HOH E 3 .   ? 21.27213  7.09298   30.52338 1.000 45.77621  ? 595 HOH A O   1 
HETATM 4436 O O   . HOH E 3 .   ? 29.472    5.863     47.918   1.000 48.89042  ? 596 HOH A O   1 
HETATM 4437 O O   . HOH E 3 .   ? 14.72294  9.68437   45.85088 1.000 57.90625  ? 597 HOH A O   1 
HETATM 4438 O O   . HOH E 3 .   ? 7.86537   0.58667   34.85954 1.000 51.97683  ? 598 HOH A O   1 
HETATM 4439 O O   . HOH E 3 .   ? 28.08115  -14.79362 40.94142 1.000 46.10688  ? 599 HOH A O   1 
HETATM 4440 O O   . HOH E 3 .   ? 5.03288   14.53331  46.56030 1.000 72.88815  ? 600 HOH A O   1 
HETATM 4441 O O   . HOH E 3 .   ? 17.06999  19.02812  9.91671  1.000 51.80766  ? 601 HOH A O   1 
HETATM 4442 O O   . HOH E 3 .   ? 32.47543  14.00560  13.42404 1.000 68.94972  ? 602 HOH A O   1 
HETATM 4443 O O   . HOH E 3 .   ? 7.63083   2.17882   32.17087 1.000 52.18778  ? 603 HOH A O   1 
HETATM 4444 O O   . HOH E 3 .   ? 35.25974  9.65763   22.41536 1.000 57.12756  ? 604 HOH A O   1 
HETATM 4445 O O   . HOH E 3 .   ? 12.51416  -18.98299 42.23146 1.000 60.63311  ? 605 HOH A O   1 
HETATM 4446 O O   . HOH E 3 .   ? 4.45295   8.44993   25.82502 1.000 41.55890  ? 606 HOH A O   1 
HETATM 4447 O O   . HOH E 3 .   ? 4.56891   -7.96107  13.58499 1.000 47.73620  ? 607 HOH A O   1 
HETATM 4448 O O   . HOH E 3 .   ? 24.18873  17.18045  20.93753 1.000 43.84741  ? 608 HOH A O   1 
HETATM 4449 O O   . HOH E 3 .   ? 12.92261  -15.09265 33.97050 1.000 40.05889  ? 609 HOH A O   1 
HETATM 4450 O O   . HOH E 3 .   ? 27.79458  -1.52847  46.82543 1.000 56.22288  ? 610 HOH A O   1 
HETATM 4451 O O   . HOH E 3 .   ? 31.68675  1.09486   17.91685 1.000 48.27126  ? 611 HOH A O   1 
HETATM 4452 O O   . HOH E 3 .   ? 24.41187  -2.23836  29.33460 1.000 33.26180  ? 612 HOH A O   1 
HETATM 4453 O O   . HOH E 3 .   ? 18.97020  17.79376  10.50490 1.000 56.79154  ? 613 HOH A O   1 
HETATM 4454 O O   . HOH E 3 .   ? 4.16828   11.27249  34.62141 1.000 61.64522  ? 614 HOH A O   1 
HETATM 4455 O O   . HOH E 3 .   ? 29.68133  -1.17102  16.57842 1.000 41.75097  ? 615 HOH A O   1 
HETATM 4456 O O   . HOH E 3 .   ? -0.85816  1.69009   19.78947 1.000 47.57445  ? 616 HOH A O   1 
HETATM 4457 O O   . HOH E 3 .   ? 28.57730  8.87716   30.43710 1.000 45.42766  ? 617 HOH A O   1 
HETATM 4458 O O   . HOH E 3 .   ? 22.22739  -13.06013 52.17937 1.000 64.40463  ? 618 HOH A O   1 
HETATM 4459 O O   . HOH E 3 .   ? 24.13002  8.57954   13.87036 1.000 68.09617  ? 619 HOH A O   1 
HETATM 4460 O O   . HOH E 3 .   ? 30.47566  10.01480  26.98593 1.000 50.17195  ? 620 HOH A O   1 
HETATM 4461 O O   . HOH E 3 .   ? 8.834     21.022    21.253   1.000 37.08497  ? 621 HOH A O   1 
HETATM 4462 O O   . HOH E 3 .   ? 16.14336  -11.71506 17.29318 1.000 51.37376  ? 622 HOH A O   1 
HETATM 4463 O O   . HOH E 3 .   ? 22.87554  -4.32354  25.32759 1.000 42.14558  ? 623 HOH A O   1 
HETATM 4464 O O   . HOH E 3 .   ? 9.10121   4.37524   30.51154 1.000 38.53627  ? 624 HOH A O   1 
HETATM 4465 O O   . HOH E 3 .   ? -0.36236  3.77176   27.64101 1.000 47.94065  ? 625 HOH A O   1 
HETATM 4466 O O   . HOH E 3 .   ? 26.236    -11.629   23.262   1.000 37.80014  ? 626 HOH A O   1 
HETATM 4467 O O   . HOH E 3 .   ? 6.28358   -18.73316 51.53956 1.000 68.96542  ? 627 HOH A O   1 
HETATM 4468 O O   . HOH E 3 .   ? 33.43041  11.27847  21.81588 1.000 61.24254  ? 628 HOH A O   1 
HETATM 4469 O O   . HOH E 3 .   ? 23.57978  19.33535  25.18715 1.000 44.63506  ? 629 HOH A O   1 
HETATM 4470 O O   . HOH E 3 .   ? 2.90209   -3.57598  8.23197  1.000 61.17083  ? 630 HOH A O   1 
HETATM 4471 O O   . HOH E 3 .   ? 20.38509  19.34970  12.54181 1.000 47.67361  ? 631 HOH A O   1 
HETATM 4472 O O   . HOH E 3 .   ? 27.80174  2.78390   9.46513  1.000 60.81826  ? 632 HOH A O   1 
HETATM 4473 O O   . HOH E 3 .   ? 3.52613   14.67447  34.78038 1.000 55.05044  ? 633 HOH A O   1 
HETATM 4474 O O   . HOH E 3 .   ? 20.13820  7.13040   3.13165  1.000 72.77134  ? 634 HOH A O   1 
HETATM 4475 O O   . HOH E 3 .   ? -0.19192  20.86744  10.15115 1.000 59.85810  ? 635 HOH A O   1 
HETATM 4476 O O   . HOH E 3 .   ? 26.98190  16.03975  24.58176 1.000 46.75836  ? 636 HOH A O   1 
HETATM 4477 O O   . HOH E 3 .   ? 14.28631  11.38181  43.04229 1.000 55.77736  ? 637 HOH A O   1 
HETATM 4478 O O   . HOH E 3 .   ? 26.46458  -1.86265  53.21447 1.000 56.97584  ? 638 HOH A O   1 
HETATM 4479 O O   . HOH E 3 .   ? 31.47122  4.45118   16.76918 1.000 54.15992  ? 639 HOH A O   1 
HETATM 4480 O O   . HOH E 3 .   ? 25.12098  6.56873   13.99205 1.000 54.35950  ? 640 HOH A O   1 
HETATM 4481 O O   . HOH E 3 .   ? 0.47581   -16.01543 31.42234 1.000 54.90310  ? 641 HOH A O   1 
HETATM 4482 O O   . HOH E 3 .   ? 1.33231   -7.89348  38.76320 1.000 51.53027  ? 642 HOH A O   1 
HETATM 4483 O O   . HOH E 3 .   ? 30.54132  -0.16675  13.21231 1.000 55.37633  ? 643 HOH A O   1 
HETATM 4484 O O   . HOH E 3 .   ? 9.60586   0.20130   36.53333 1.000 51.80985  ? 644 HOH A O   1 
HETATM 4485 O O   . HOH E 3 .   ? 2.59944   4.69170   30.55261 1.000 44.88547  ? 645 HOH A O   1 
HETATM 4486 O O   . HOH E 3 .   ? 20.76670  -6.40242  25.47321 1.000 33.20578  ? 646 HOH A O   1 
HETATM 4487 O O   . HOH E 3 .   ? 7.60556   24.12196  7.94637  1.000 67.61406  ? 647 HOH A O   1 
HETATM 4488 O O   . HOH E 3 .   ? 35.41180  8.57330   25.50171 1.000 59.60817  ? 648 HOH A O   1 
HETATM 4489 O O   . HOH E 3 .   ? 31.329    -16.242   46.658   1.000 49.30649  ? 649 HOH A O   1 
HETATM 4490 O O   . HOH E 3 .   ? 18.87045  -11.01204 24.84382 1.000 51.65304  ? 650 HOH A O   1 
HETATM 4491 O O   . HOH E 3 .   ? 1.13407   -0.84694  30.95359 1.000 48.16855  ? 651 HOH A O   1 
HETATM 4492 O O   . HOH E 3 .   ? 30.16710  3.98592   39.89772 1.000 54.66797  ? 652 HOH A O   1 
HETATM 4493 O O   . HOH E 3 .   ? 0.68141   2.74507   29.95796 1.000 48.35824  ? 653 HOH A O   1 
HETATM 4494 O O   . HOH E 3 .   ? 19.58359  2.76630   6.60298  1.000 60.43301  ? 654 HOH A O   1 
HETATM 4495 O O   . HOH E 3 .   ? -0.82283  13.42184  27.74275 1.000 45.45649  ? 655 HOH A O   1 
HETATM 4496 O O   . HOH E 3 .   ? -3.54307  8.67498   27.13321 1.000 47.19977  ? 656 HOH A O   1 
HETATM 4497 O O   . HOH E 3 .   ? 25.66204  21.43112  18.37138 1.000 53.34577  ? 657 HOH A O   1 
HETATM 4498 O O   . HOH E 3 .   ? 7.91581   -17.48981 13.92944 1.000 73.25375  ? 658 HOH A O   1 
HETATM 4499 O O   . HOH E 3 .   ? 10.30841  1.19938   31.81822 1.000 44.76197  ? 659 HOH A O   1 
HETATM 4500 O O   . HOH E 3 .   ? 24.68131  -3.74462  53.72027 1.000 67.68466  ? 660 HOH A O   1 
HETATM 4501 O O   . HOH E 3 .   ? 20.39671  -13.70600 28.15879 1.000 52.55510  ? 661 HOH A O   1 
HETATM 4502 O O   . HOH E 3 .   ? 2.22812   5.72442   28.48055 1.000 42.53434  ? 662 HOH A O   1 
HETATM 4503 O O   . HOH E 3 .   ? 21.48483  6.22590   1.97002  1.000 66.37205  ? 663 HOH A O   1 
HETATM 4504 O O   . HOH E 3 .   ? 4.15692   16.84860  35.05746 1.000 56.42218  ? 664 HOH A O   1 
HETATM 4505 O O   . HOH E 3 .   ? 10.59559  1.58027   34.05717 1.000 50.67615  ? 665 HOH A O   1 
HETATM 4506 O O   . HOH E 3 .   ? 1.04849   -6.82908  20.23240 1.000 46.46403  ? 666 HOH A O   1 
HETATM 4507 O O   . HOH E 3 .   ? 2.47919   -15.69808 27.59765 1.000 49.17198  ? 667 HOH A O   1 
HETATM 4508 O O   . HOH E 3 .   ? 28.29039  6.35510   30.87029 1.000 49.96750  ? 668 HOH A O   1 
HETATM 4509 O O   . HOH E 3 .   ? 3.39124   -19.79327 29.37841 1.000 50.60755  ? 669 HOH A O   1 
HETATM 4510 O O   . HOH E 3 .   ? 17.49295  -22.38622 40.69721 1.000 64.74244  ? 670 HOH A O   1 
HETATM 4511 O O   . HOH E 3 .   ? 6.105     -4.308    52.164   1.000 59.84625  ? 671 HOH A O   1 
HETATM 4512 O O   . HOH E 3 .   ? 25.53398  4.83647   29.85073 1.000 39.99348  ? 672 HOH A O   1 
HETATM 4513 O O   . HOH E 3 .   ? 2.11580   -8.98742  26.28954 1.000 49.63180  ? 673 HOH A O   1 
HETATM 4514 O O   . HOH E 3 .   ? 30.44239  2.20918   11.60730 1.000 59.06901  ? 674 HOH A O   1 
HETATM 4515 O O   . HOH E 3 .   ? 3.63878   -8.81434  22.65570 1.000 45.71849  ? 675 HOH A O   1 
HETATM 4516 O O   . HOH E 3 .   ? 28.59867  7.84434   32.09535 1.000 54.43245  ? 676 HOH A O   1 
HETATM 4517 O O   . HOH E 3 .   ? 0.41208   20.81122  16.00493 1.000 60.97172  ? 677 HOH A O   1 
HETATM 4518 O O   . HOH E 3 .   ? 22.80060  0.31774   9.34434  1.000 56.95289  ? 678 HOH A O   1 
HETATM 4519 O O   . HOH E 3 .   ? 30.29820  -5.35266  28.01685 1.000 43.02165  ? 679 HOH A O   1 
HETATM 4520 O O   . HOH E 3 .   ? 25.807    -12.178   25.014   1.000 48.56443  ? 680 HOH A O   1 
HETATM 4521 O O   . HOH E 3 .   ? -3.315    25.685    20.572   1.000 65.26214  ? 681 HOH A O   1 
HETATM 4522 O O   . HOH E 3 .   ? -6.76858  9.73362   26.29164 1.000 54.80955  ? 682 HOH A O   1 
HETATM 4523 O O   . HOH E 3 .   ? 12.55414  16.67949  37.48163 1.000 46.11056  ? 683 HOH A O   1 
HETATM 4524 O O   . HOH E 3 .   ? -0.84539  -1.90761  21.26610 1.000 43.09154  ? 684 HOH A O   1 
HETATM 4525 O O   . HOH E 3 .   ? 0.31833   23.65519  8.34950  1.000 66.58643  ? 685 HOH A O   1 
HETATM 4526 O O   . HOH E 3 .   ? 3.31328   8.71539   27.43460 1.000 51.64351  ? 686 HOH A O   1 
HETATM 4527 O O   . HOH E 3 .   ? 26.51145  -0.21040  29.62877 1.000 40.75665  ? 687 HOH A O   1 
HETATM 4528 O O   . HOH E 3 .   ? 27.29426  7.08140   35.39841 1.000 54.85235  ? 688 HOH A O   1 
HETATM 4529 O O   . HOH E 3 .   ? 4.92817   -0.08926  35.54707 1.000 55.49586  ? 689 HOH A O   1 
HETATM 4530 O O   . HOH E 3 .   ? 36.45940  10.84825  25.30469 1.000 52.36262  ? 690 HOH A O   1 
HETATM 4531 O O   . HOH E 3 .   ? -2.66693  -0.23790  22.10985 1.000 53.16664  ? 691 HOH A O   1 
HETATM 4532 O O   . HOH E 3 .   ? 22.36706  -9.67394  21.61515 1.000 47.38911  ? 692 HOH A O   1 
HETATM 4533 O O   . HOH E 3 .   ? 0.68580   10.63380  27.05282 1.000 49.86092  ? 693 HOH A O   1 
HETATM 4534 O O   . HOH E 3 .   ? 17.34717  -13.65299 22.45276 1.000 48.28841  ? 694 HOH A O   1 
HETATM 4535 O O   . HOH E 3 .   ? 1.98577   23.29462  6.84920  1.000 58.37764  ? 695 HOH A O   1 
HETATM 4536 O O   . HOH E 3 .   ? 28.993    -12.059   28.353   1.000 42.57857  ? 696 HOH A O   1 
HETATM 4537 O O   . HOH E 3 .   ? 28.01824  5.26146   33.06397 1.000 56.16648  ? 697 HOH A O   1 
HETATM 4538 O O   . HOH E 3 .   ? 30.948    -18.118   47.868   1.000 62.50601  ? 698 HOH A O   1 
HETATM 4539 O O   . HOH E 3 .   ? 14.56717  -21.62342 42.02614 1.000 57.99610  ? 699 HOH A O   1 
HETATM 4540 O O   . HOH E 3 .   ? -1.85571  20.95370  7.94778  1.000 68.78111  ? 700 HOH A O   1 
HETATM 4541 O O   . HOH E 3 .   ? -15.48298 14.66844  28.51692 1.000 57.52942  ? 701 HOH A O   1 
HETATM 4542 O O   . HOH F 3 .   ? -15.78700 -13.97916 13.75832 1.000 50.92734  ? 501 HOH B O   1 
HETATM 4543 O O   . HOH F 3 .   ? -14.83565 -5.07904  23.53784 1.000 39.40848  ? 502 HOH B O   1 
HETATM 4544 O O   . HOH F 3 .   ? 3.67040   -22.16562 23.15781 1.000 46.53825  ? 503 HOH B O   1 
HETATM 4545 O O   . HOH F 3 .   ? -18.72699 12.87156  38.69104 1.000 58.59303  ? 504 HOH B O   1 
HETATM 4546 O O   . HOH F 3 .   ? -11.81444 -11.79967 29.88267 1.000 49.61188  ? 505 HOH B O   1 
HETATM 4547 O O   . HOH F 3 .   ? -6.71678  -16.19959 40.38758 1.000 65.56491  ? 506 HOH B O   1 
HETATM 4548 O O   . HOH F 3 .   ? -21.00727 -19.01536 37.27589 1.000 40.62983  ? 507 HOH B O   1 
HETATM 4549 O O   . HOH F 3 .   ? -18.50512 -13.36364 51.96735 1.000 58.60514  ? 508 HOH B O   1 
HETATM 4550 O O   . HOH F 3 .   ? -26.11284 3.78807   39.56438 1.000 43.07826  ? 509 HOH B O   1 
HETATM 4551 O O   . HOH F 3 .   ? -6.57304  3.56503   12.03242 1.000 74.95616  ? 510 HOH B O   1 
HETATM 4552 O O   . HOH F 3 .   ? -11.17214 -12.46416 54.18651 1.000 61.38281  ? 511 HOH B O   1 
HETATM 4553 O O   . HOH F 3 .   ? -10.19541 -5.87851  28.25790 1.000 39.96421  ? 512 HOH B O   1 
HETATM 4554 O O   . HOH F 3 .   ? -16.40791 9.72026   52.17314 1.000 69.36880  ? 513 HOH B O   1 
HETATM 4555 O O   . HOH F 3 .   ? -10.84246 0.05288   16.43081 1.000 50.39283  ? 514 HOH B O   1 
HETATM 4556 O O   . HOH F 3 .   ? -2.86858  -11.06046 4.08031  1.000 65.97238  ? 515 HOH B O   1 
HETATM 4557 O O   . HOH F 3 .   ? -22.96002 -22.79131 31.00407 1.000 41.07763  ? 516 HOH B O   1 
HETATM 4558 O O   . HOH F 3 .   ? -17.25959 -20.18648 7.79583  1.000 79.50385  ? 517 HOH B O   1 
HETATM 4559 O O   . HOH F 3 .   ? -13.64605 7.45332   36.33020 1.000 51.91072  ? 518 HOH B O   1 
HETATM 4560 O O   . HOH F 3 .   ? -23.67279 9.30888   53.17612 1.000 72.20934  ? 519 HOH B O   1 
HETATM 4561 O O   . HOH F 3 .   ? -28.76597 -13.83329 48.36074 1.000 51.81906  ? 520 HOH B O   1 
HETATM 4562 O O   . HOH F 3 .   ? -8.88071  -8.02696  21.49626 1.000 40.75581  ? 521 HOH B O   1 
HETATM 4563 O O   . HOH F 3 .   ? -15.16841 -12.97226 9.21976  1.000 65.15761  ? 522 HOH B O   1 
HETATM 4564 O O   . HOH F 3 .   ? -29.006   -5.324    43.017   1.000 51.64390  ? 523 HOH B O   1 
HETATM 4565 O O   . HOH F 3 .   ? 2.83956   -13.40753 25.92547 1.000 41.64954  ? 524 HOH B O   1 
HETATM 4566 O O   . HOH F 3 .   ? -14.06220 -9.74704  20.76101 1.000 36.47420  ? 525 HOH B O   1 
HETATM 4567 O O   . HOH F 3 .   ? -7.20934  -2.83516  33.60275 1.000 39.66341  ? 526 HOH B O   1 
HETATM 4568 O O   . HOH F 3 .   ? -0.96803  6.47274   14.39633 1.000 45.02151  ? 527 HOH B O   1 
HETATM 4569 O O   . HOH F 3 .   ? -28.93338 -1.77904  45.66094 1.000 55.83627  ? 528 HOH B O   1 
HETATM 4570 O O   . HOH F 3 .   ? -16.34840 -10.26081 19.34178 1.000 32.96810  ? 529 HOH B O   1 
HETATM 4571 O O   . HOH F 3 .   ? -15.34573 -11.72478 22.41900 1.000 37.90210  ? 530 HOH B O   1 
HETATM 4572 O O   . HOH F 3 .   ? -19.85906 -0.30564  23.77803 1.000 43.25726  ? 531 HOH B O   1 
HETATM 4573 O O   . HOH F 3 .   ? -19.392   -29.210   32.063   1.000 39.82373  ? 532 HOH B O   1 
HETATM 4574 O O   . HOH F 3 .   ? -0.40940  -17.37384 13.24085 1.000 35.71117  ? 533 HOH B O   1 
HETATM 4575 O O   . HOH F 3 .   ? -23.22074 -21.78022 28.52793 1.000 36.68119  ? 534 HOH B O   1 
HETATM 4576 O O   . HOH F 3 .   ? -10.92176 -7.01583  38.09448 1.000 42.04178  ? 535 HOH B O   1 
HETATM 4577 O O   . HOH F 3 .   ? -21.99547 -15.33097 27.96572 1.000 38.90101  ? 536 HOH B O   1 
HETATM 4578 O O   . HOH F 3 .   ? -23.44517 -3.35593  28.22794 1.000 32.03888  ? 537 HOH B O   1 
HETATM 4579 O O   . HOH F 3 .   ? -11.30404 2.95900   29.74692 1.000 36.77181  ? 538 HOH B O   1 
HETATM 4580 O O   . HOH F 3 .   ? -28.653   3.937     20.094   1.000 51.72958  ? 539 HOH B O   1 
HETATM 4581 O O   . HOH F 3 .   ? -9.39181  5.34536   14.29065 1.000 68.74976  ? 540 HOH B O   1 
HETATM 4582 O O   . HOH F 3 .   ? -28.60203 -8.57254  28.20827 1.000 39.69093  ? 541 HOH B O   1 
HETATM 4583 O O   . HOH F 3 .   ? -12.85636 -1.96107  24.12038 1.000 36.07020  ? 542 HOH B O   1 
HETATM 4584 O O   . HOH F 3 .   ? 0.97575   -10.46634 20.35901 1.000 48.22942  ? 543 HOH B O   1 
HETATM 4585 O O   . HOH F 3 .   ? -14.37661 0.79730   28.03370 1.000 31.36243  ? 544 HOH B O   1 
HETATM 4586 O O   . HOH F 3 .   ? -1.78372  -0.99307  29.32967 1.000 39.66053  ? 545 HOH B O   1 
HETATM 4587 O O   . HOH F 3 .   ? -21.08119 -15.83525 30.11602 1.000 38.11113  ? 546 HOH B O   1 
HETATM 4588 O O   . HOH F 3 .   ? -16.72293 -27.85573 10.21252 1.000 56.23699  ? 547 HOH B O   1 
HETATM 4589 O O   . HOH F 3 .   ? -22.30825 -12.28361 34.63430 1.000 47.53652  ? 548 HOH B O   1 
HETATM 4590 O O   . HOH F 3 .   ? -35.49104 -9.17186  21.77074 1.000 47.10966  ? 549 HOH B O   1 
HETATM 4591 O O   . HOH F 3 .   ? -31.14086 -3.01818  43.60568 1.000 55.65805  ? 550 HOH B O   1 
HETATM 4592 O O   . HOH F 3 .   ? -2.16509  2.12359   32.31129 1.000 42.64901  ? 551 HOH B O   1 
HETATM 4593 O O   . HOH F 3 .   ? -17.75378 -9.22194  30.00580 1.000 35.70299  ? 552 HOH B O   1 
HETATM 4594 O O   . HOH F 3 .   ? -30.03392 -5.98062  25.60475 1.000 37.85263  ? 553 HOH B O   1 
HETATM 4595 O O   . HOH F 3 .   ? -27.97215 -8.60661  18.16579 1.000 36.07512  ? 554 HOH B O   1 
HETATM 4596 O O   . HOH F 3 .   ? -2.16191  7.99113   16.21728 1.000 50.58311  ? 555 HOH B O   1 
HETATM 4597 O O   . HOH F 3 .   ? -27.71003 -7.39081  47.03820 1.000 58.05815  ? 556 HOH B O   1 
HETATM 4598 O O   . HOH F 3 .   ? -14.46229 -26.48656 9.82525  1.000 49.20247  ? 557 HOH B O   1 
HETATM 4599 O O   . HOH F 3 .   ? -26.58808 -24.01328 24.08481 1.000 47.64584  ? 558 HOH B O   1 
HETATM 4600 O O   . HOH F 3 .   ? -10.25129 -27.78620 28.97385 1.000 39.58607  ? 559 HOH B O   1 
HETATM 4601 O O   . HOH F 3 .   ? -8.95943  -11.56255 24.92249 1.000 33.79734  ? 560 HOH B O   1 
HETATM 4602 O O   . HOH F 3 .   ? -2.81660  -5.15955  34.77048 1.000 55.63891  ? 561 HOH B O   1 
HETATM 4603 O O   . HOH F 3 .   ? 2.44420   -19.07636 24.83565 1.000 38.22178  ? 562 HOH B O   1 
HETATM 4604 O O   . HOH F 3 .   ? -4.84474  -2.14984  23.32677 1.000 49.72277  ? 563 HOH B O   1 
HETATM 4605 O O   . HOH F 3 .   ? -19.316   -28.126   34.180   1.000 44.03530  ? 564 HOH B O   1 
HETATM 4606 O O   . HOH F 3 .   ? -9.74003  -13.61034 23.87185 1.000 29.80792  ? 565 HOH B O   1 
HETATM 4607 O O   . HOH F 3 .   ? -14.28329 -10.36781 29.13581 1.000 36.40413  ? 566 HOH B O   1 
HETATM 4608 O O   . HOH F 3 .   ? -6.97946  -8.55483  10.86862 1.000 51.85035  ? 567 HOH B O   1 
HETATM 4609 O O   . HOH F 3 .   ? -13.45220 -2.85818  21.68256 1.000 37.27821  ? 568 HOH B O   1 
HETATM 4610 O O   . HOH F 3 .   ? -18.01202 -16.62292 14.96779 1.000 53.00799  ? 569 HOH B O   1 
HETATM 4611 O O   . HOH F 3 .   ? -11.80859 1.04546   27.48515 1.000 30.30019  ? 570 HOH B O   1 
HETATM 4612 O O   . HOH F 3 .   ? -29.372   -10.717   19.348   1.000 43.51953  ? 571 HOH B O   1 
HETATM 4613 O O   . HOH F 3 .   ? -26.41872 -23.56767 20.38891 1.000 44.57735  ? 572 HOH B O   1 
HETATM 4614 O O   . HOH F 3 .   ? -12.68472 -8.56503  28.98519 1.000 42.38099  ? 573 HOH B O   1 
HETATM 4615 O O   . HOH F 3 .   ? -26.58497 -13.29859 40.17624 1.000 45.65937  ? 574 HOH B O   1 
HETATM 4616 O O   . HOH F 3 .   ? -27.895   -2.270    28.712   1.000 38.29481  ? 575 HOH B O   1 
HETATM 4617 O O   . HOH F 3 .   ? -24.23642 -13.78123 27.47161 1.000 33.95398  ? 576 HOH B O   1 
HETATM 4618 O O   . HOH F 3 .   ? -4.31001  -17.31525 25.79723 1.000 41.09944  ? 577 HOH B O   1 
HETATM 4619 O O   . HOH F 3 .   ? -14.32667 7.22451   32.63965 1.000 50.19744  ? 578 HOH B O   1 
HETATM 4620 O O   . HOH F 3 .   ? -12.46119 6.31234   33.81692 1.000 43.89915  ? 579 HOH B O   1 
HETATM 4621 O O   . HOH F 3 .   ? -21.09670 15.47276  38.88964 1.000 73.48947  ? 580 HOH B O   1 
HETATM 4622 O O   . HOH F 3 .   ? -15.75248 2.51853   17.27430 1.000 45.24209  ? 581 HOH B O   1 
HETATM 4623 O O   . HOH F 3 .   ? -14.56745 -18.44416 45.78460 1.000 60.03451  ? 582 HOH B O   1 
HETATM 4624 O O   . HOH F 3 .   ? -2.92429  -19.83119 24.20932 1.000 39.48328  ? 583 HOH B O   1 
HETATM 4625 O O   . HOH F 3 .   ? -22.62222 -6.76739  26.79541 1.000 30.23769  ? 584 HOH B O   1 
HETATM 4626 O O   . HOH F 3 .   ? -27.61859 -1.48854  15.48533 1.000 53.43367  ? 585 HOH B O   1 
HETATM 4627 O O   . HOH F 3 .   ? -22.88064 -13.95291 31.47313 1.000 46.82372  ? 586 HOH B O   1 
HETATM 4628 O O   . HOH F 3 .   ? -34.47809 -10.97237 19.78751 1.000 42.18225  ? 587 HOH B O   1 
HETATM 4629 O O   . HOH F 3 .   ? -3.78368  -14.27841 26.05509 1.000 38.02948  ? 588 HOH B O   1 
HETATM 4630 O O   . HOH F 3 .   ? -24.31958 9.36034   41.15778 1.000 59.88667  ? 589 HOH B O   1 
HETATM 4631 O O   . HOH F 3 .   ? -34.93728 -18.02376 22.14332 1.000 58.11461  ? 590 HOH B O   1 
HETATM 4632 O O   . HOH F 3 .   ? -9.20343  -8.61692  25.33213 1.000 34.88899  ? 591 HOH B O   1 
HETATM 4633 O O   . HOH F 3 .   ? -25.96254 -7.09932  53.02232 1.000 65.74304  ? 592 HOH B O   1 
HETATM 4634 O O   . HOH F 3 .   ? -22.50009 0.37309   19.23324 1.000 34.86053  ? 593 HOH B O   1 
HETATM 4635 O O   . HOH F 3 .   ? -29.88302 -22.12435 19.68281 1.000 56.16954  ? 594 HOH B O   1 
HETATM 4636 O O   . HOH F 3 .   ? -10.26884 -9.55854  28.23925 1.000 38.06904  ? 595 HOH B O   1 
HETATM 4637 O O   . HOH F 3 .   ? -28.05742 -20.03221 39.91636 1.000 60.08257  ? 596 HOH B O   1 
HETATM 4638 O O   . HOH F 3 .   ? -31.32501 -9.08528  17.76501 1.000 74.04152  ? 597 HOH B O   1 
HETATM 4639 O O   . HOH F 3 .   ? -29.77434 -20.49142 24.14872 1.000 50.21728  ? 598 HOH B O   1 
HETATM 4640 O O   . HOH F 3 .   ? -20.44605 -15.24618 50.26203 1.000 57.84212  ? 599 HOH B O   1 
HETATM 4641 O O   . HOH F 3 .   ? 0.43130   -12.47776 27.57277 1.000 41.29945  ? 600 HOH B O   1 
HETATM 4642 O O   . HOH F 3 .   ? -26.58759 -8.41533  36.01634 1.000 51.77907  ? 601 HOH B O   1 
HETATM 4643 O O   . HOH F 3 .   ? -3.02910  -7.01134  38.19691 1.000 50.93220  ? 602 HOH B O   1 
HETATM 4644 O O   . HOH F 3 .   ? -0.99973  -0.54148  38.62408 1.000 51.29468  ? 603 HOH B O   1 
HETATM 4645 O O   . HOH F 3 .   ? -20.21659 -12.77677 33.05930 1.000 51.02204  ? 604 HOH B O   1 
HETATM 4646 O O   . HOH F 3 .   ? -32.179   -12.699   19.730   1.000 51.95825  ? 605 HOH B O   1 
HETATM 4647 O O   . HOH F 3 .   ? -3.97852  -2.82121  33.44458 1.000 47.11592  ? 606 HOH B O   1 
HETATM 4648 O O   . HOH F 3 .   ? -23.92270 -6.46266  29.26437 1.000 31.10370  ? 607 HOH B O   1 
HETATM 4649 O O   . HOH F 3 .   ? -23.38059 -27.90128 25.27833 1.000 47.73239  ? 608 HOH B O   1 
HETATM 4650 O O   . HOH F 3 .   ? -14.64625 9.93287   12.30101 1.000 75.15138  ? 609 HOH B O   1 
HETATM 4651 O O   . HOH F 3 .   ? -9.85448  -9.27810  30.26837 1.000 46.32851  ? 610 HOH B O   1 
HETATM 4652 O O   . HOH F 3 .   ? -28.96460 -7.85441  16.94114 1.000 46.83644  ? 611 HOH B O   1 
HETATM 4653 O O   . HOH F 3 .   ? -29.87809 -18.69221 27.02894 1.000 48.66045  ? 612 HOH B O   1 
HETATM 4654 O O   . HOH F 3 .   ? -28.34018 -17.57383 30.51832 1.000 40.52445  ? 613 HOH B O   1 
HETATM 4655 O O   . HOH F 3 .   ? -23.40414 -28.53925 11.25262 1.000 66.43389  ? 614 HOH B O   1 
HETATM 4656 O O   . HOH F 3 .   ? -0.99766  -8.05976  30.58277 1.000 46.04379  ? 615 HOH B O   1 
HETATM 4657 O O   . HOH F 3 .   ? -8.68234  -13.05098 30.37613 1.000 39.56158  ? 616 HOH B O   1 
HETATM 4658 O O   . HOH F 3 .   ? -23.58413 -17.00612 13.75325 1.000 64.50675  ? 617 HOH B O   1 
HETATM 4659 O O   . HOH F 3 .   ? -0.81932  -8.79478  16.89412 1.000 41.68426  ? 618 HOH B O   1 
HETATM 4660 O O   . HOH F 3 .   ? -22.49964 -4.30759  25.43080 1.000 36.77453  ? 619 HOH B O   1 
HETATM 4661 O O   . HOH F 3 .   ? -25.736   3.089     23.541   1.000 39.35716  ? 620 HOH B O   1 
HETATM 4662 O O   . HOH F 3 .   ? -0.36145  7.38872   30.97887 1.000 54.65816  ? 621 HOH B O   1 
HETATM 4663 O O   . HOH F 3 .   ? -0.66297  -5.77383  45.56168 1.000 66.15517  ? 622 HOH B O   1 
HETATM 4664 O O   . HOH F 3 .   ? -10.05205 -9.87214  32.58976 1.000 47.96985  ? 623 HOH B O   1 
HETATM 4665 O O   . HOH F 3 .   ? -20.34535 -2.39319  25.44026 1.000 25.21895  ? 624 HOH B O   1 
HETATM 4666 O O   . HOH F 3 .   ? 0.33650   -6.59398  23.97208 1.000 40.69928  ? 625 HOH B O   1 
HETATM 4667 O O   . HOH F 3 .   ? -29.91808 -12.68041 40.05039 1.000 53.17609  ? 626 HOH B O   1 
HETATM 4668 O O   . HOH F 3 .   ? -14.38553 5.42125   57.85585 1.000 67.19166  ? 627 HOH B O   1 
HETATM 4669 O O   . HOH F 3 .   ? -26.73919 0.80997   15.67763 1.000 59.37357  ? 628 HOH B O   1 
HETATM 4670 O O   . HOH F 3 .   ? -0.73475  -5.00386  33.55447 1.000 54.69038  ? 629 HOH B O   1 
HETATM 4671 O O   . HOH F 3 .   ? -23.563   -31.414   29.210   1.000 39.95629  ? 630 HOH B O   1 
HETATM 4672 O O   . HOH F 3 .   ? 3.52501   -27.38466 11.52844 1.000 70.82831  ? 631 HOH B O   1 
HETATM 4673 O O   . HOH F 3 .   ? 0.79286   -1.95753  45.33486 1.000 74.57180  ? 632 HOH B O   1 
HETATM 4674 O O   . HOH F 3 .   ? -25.03218 -13.82358 29.05853 1.000 40.98015  ? 633 HOH B O   1 
HETATM 4675 O O   . HOH F 3 .   ? -14.86216 -13.30082 33.43550 1.000 53.66422  ? 634 HOH B O   1 
HETATM 4676 O O   . HOH F 3 .   ? -8.918    -29.684   21.430   1.000 40.47172  ? 635 HOH B O   1 
HETATM 4677 O O   . HOH F 3 .   ? -10.505   -26.197   38.599   1.000 47.45115  ? 636 HOH B O   1 
HETATM 4678 O O   . HOH F 3 .   ? -14.56833 -14.41342 31.65504 1.000 57.12730  ? 637 HOH B O   1 
HETATM 4679 O O   . HOH F 3 .   ? -14.69947 -1.53320  57.36734 1.000 65.90999  ? 638 HOH B O   1 
HETATM 4680 O O   . HOH F 3 .   ? -23.99153 -5.09602  53.47950 1.000 63.05486  ? 639 HOH B O   1 
HETATM 4681 O O   . HOH F 3 .   ? -9.99073  -19.06247 36.65557 1.000 55.19119  ? 640 HOH B O   1 
HETATM 4682 O O   . HOH F 3 .   ? 4.63630   -18.21675 26.99532 1.000 49.44897  ? 641 HOH B O   1 
HETATM 4683 O O   . HOH F 3 .   ? -16.03503 -11.46994 31.39222 1.000 46.03470  ? 642 HOH B O   1 
HETATM 4684 O O   . HOH F 3 .   ? -31.01566 8.08815   46.12045 1.000 49.73456  ? 643 HOH B O   1 
HETATM 4685 O O   . HOH F 3 .   ? -24.98942 -15.36015 14.11105 1.000 61.42860  ? 644 HOH B O   1 
HETATM 4686 O O   . HOH F 3 .   ? -5.45244  0.02717   22.65346 1.000 49.79337  ? 645 HOH B O   1 
HETATM 4687 O O   . HOH F 3 .   ? -29.64599 -22.03166 22.33274 1.000 56.11870  ? 646 HOH B O   1 
HETATM 4688 O O   . HOH F 3 .   ? -0.26430  -6.99663  32.18426 1.000 51.74263  ? 647 HOH B O   1 
HETATM 4689 O O   . HOH F 3 .   ? -1.57069  1.68240   27.78321 1.000 43.22345  ? 648 HOH B O   1 
HETATM 4690 O O   . HOH F 3 .   ? -0.31186  -4.22889  35.98019 1.000 58.28798  ? 649 HOH B O   1 
HETATM 4691 O O   . HOH F 3 .   ? -25.95612 -15.73089 36.31125 1.000 57.75639  ? 650 HOH B O   1 
HETATM 4692 O O   . HOH F 3 .   ? -14.75762 8.93244   28.35359 1.000 48.79173  ? 651 HOH B O   1 
HETATM 4693 O O   . HOH F 3 .   ? -20.08309 -17.20791 49.36974 1.000 57.75449  ? 652 HOH B O   1 
HETATM 4694 O O   . HOH F 3 .   ? -27.81676 -5.38514  35.88522 1.000 51.85924  ? 653 HOH B O   1 
HETATM 4695 O O   . HOH F 3 .   ? -0.08631  -11.34436 30.24614 1.000 54.56295  ? 654 HOH B O   1 
HETATM 4696 O O   . HOH F 3 .   ? 0.88899   5.77877   32.01364 1.000 54.94057  ? 655 HOH B O   1 
HETATM 4697 O O   . HOH F 3 .   ? -6.81395  -16.89516 51.70516 1.000 67.11477  ? 656 HOH B O   1 
HETATM 4698 O O   . HOH F 3 .   ? -2.26884  7.05945   27.47824 1.000 45.77309  ? 657 HOH B O   1 
HETATM 4699 O O   . HOH F 3 .   ? -35.57158 -17.22260 19.99495 1.000 67.11558  ? 658 HOH B O   1 
HETATM 4700 O O   . HOH F 3 .   ? -19.91673 5.12574   28.07136 1.000 47.95622  ? 659 HOH B O   1 
HETATM 4701 O O   . HOH F 3 .   ? -28.04856 -14.88108 30.76013 1.000 41.12338  ? 660 HOH B O   1 
HETATM 4702 O O   . HOH F 3 .   ? -11.51806 -23.79401 5.41821  1.000 65.75532  ? 661 HOH B O   1 
HETATM 4703 O O   . HOH F 3 .   ? 6.62148   -18.54647 26.60314 1.000 51.32100  ? 662 HOH B O   1 
HETATM 4704 O O   . HOH F 3 .   ? -14.80657 -30.93254 9.21932  1.000 54.27713  ? 663 HOH B O   1 
HETATM 4705 O O   . HOH F 3 .   ? -29.926   -3.096    27.863   1.000 37.86494  ? 664 HOH B O   1 
HETATM 4706 O O   . HOH F 3 .   ? 1.52356   -7.45608  21.84171 1.000 47.64749  ? 665 HOH B O   1 
HETATM 4707 O O   . HOH F 3 .   ? -29.13733 -22.38409 24.54826 1.000 53.58010  ? 666 HOH B O   1 
HETATM 4708 O O   . HOH F 3 .   ? -12.523   -25.361   37.345   1.000 37.00410  ? 667 HOH B O   1 
HETATM 4709 O O   . HOH F 3 .   ? -30.130   -4.074    16.796   1.000 30.26300  ? 668 HOH B O   1 
HETATM 4710 O O   . HOH F 3 .   ? -2.41342  -15.43956 28.18055 1.000 57.04144  ? 669 HOH B O   1 
HETATM 4711 O O   . HOH F 3 .   ? -4.28915  -7.93123  35.77670 1.000 61.19438  ? 670 HOH B O   1 
HETATM 4712 O O   . HOH F 3 .   ? -12.90200 -15.98261 33.86619 1.000 55.34243  ? 671 HOH B O   1 
HETATM 4713 O O   . HOH F 3 .   ? -27.46216 -16.13408 34.75354 1.000 54.74595  ? 672 HOH B O   1 
HETATM 4714 O O   . HOH F 3 .   ? -26.11267 -8.58038  29.39225 1.000 39.13518  ? 673 HOH B O   1 
HETATM 4715 O O   . HOH F 3 .   ? -28.65252 -16.75064 32.42719 1.000 48.45961  ? 674 HOH B O   1 
HETATM 4716 O O   . HOH F 3 .   ? -10.45635 -11.10193 34.52576 1.000 49.76691  ? 675 HOH B O   1 
HETATM 4717 O O   . HOH F 3 .   ? -21.97040 0.95589   21.75066 1.000 39.63685  ? 676 HOH B O   1 
HETATM 4718 O O   . HOH F 3 .   ? -30.03264 -19.37914 28.82197 1.000 52.51915  ? 677 HOH B O   1 
HETATM 4719 O O   . HOH F 3 .   ? -12.15966 -13.00529 32.53495 1.000 49.14461  ? 678 HOH B O   1 
HETATM 4720 O O   . HOH F 3 .   ? -30.53703 -10.25747 29.30295 1.000 48.43463  ? 679 HOH B O   1 
HETATM 4721 O O   . HOH F 3 .   ? -20.42440 17.25667  37.70638 1.000 66.82056  ? 680 HOH B O   1 
HETATM 4722 O O   . HOH F 3 .   ? -20.51197 -16.39421 54.76680 1.000 69.19502  ? 681 HOH B O   1 
HETATM 4723 O O   . HOH F 3 .   ? -14.54875 -31.38527 6.89710  1.000 53.99680  ? 682 HOH B O   1 
HETATM 4724 O O   . HOH F 3 .   ? -21.18839 9.52313   28.42140 1.000 61.01355  ? 683 HOH B O   1 
# 
