data_9MW8
# 
_entry.id   9MW8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MW8         pdb_00009mw8 10.2210/pdb9mw8/pdb 
WWPDB D_1000291955 ?            ?                   
EMDB  EMD-48697    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-12 ? 
2 'Structure model' 1 1 2025-06-04 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    2 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_em_admin.last_update' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MW8 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                                                                    9MW6      unspecified 
PDB  .                                                                                                    9MW7      unspecified 
EMDB 'Cryo-EM structure of ancestral Dicer helicase bound to 27-bp dsRNA in post-hydrolysis closed state' EMD-48697 
'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bbass@biochem.utah.edu 
_pdbx_contact_author.name_first         Brenda 
_pdbx_contact_author.name_last          Bass 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1728-2254 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aderounmu, A.M.' 1 0000-0002-9981-7533 
'Consalvo, C.D.'  2 0000-0003-2038-4315 
'Shen, P.S.'      3 0000-0002-6256-6910 
'Bass, B.L.'      4 0000-0003-1728-2254 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? US ? ? primary Proc.Natl.Acad.Sci.USA PNASA6 0040 1091-6490 ? ? 122 ? e2500825122 e2500825122 
'Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins.' 2025 ? 
10.1073/pnas.2500825122   40434637 ? ? 
? ? ? ? ? ? ? US ? ? 1       Biorxiv                ?      ?    2692-8205 ? ? ?   ? ?           ?           
'Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins.' 2025 ? 
10.1101/2025.02.15.638221 39990435 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Aderounmu, A.M.' 1  0000-0002-9981-7533 
primary 'Maus-Conn, J.'   2  0009-0000-7505-0385 
primary 'Consalvo, C.D.'  3  0000-0003-2038-4315 
primary 'Shen, P.S.'      4  0000-0002-6256-6910 
primary 'Bass, B.L.'      5  0000-0003-1728-2254 
1       'Aderounmu, A.M.' 6  0000-0002-9981-7533 
1       'Maus-Conn, J.'   7  0009-0000-7505-0385 
1       'Consalvo, C.D.'  8  0000-0003-2038-4315 
1       'Shen, P.S.'      9  0000-0002-6256-6910 
1       'Bass, B.L.'      10 0000-0003-1728-2254 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man AncD1D2                    75480.609 1 ? ? ? ? 
2 polymer     man 'RNA (27-MER)'             8572.096  1 ? ? ? ? 
3 polymer     man 'RNA (27-MER)'             8658.198  1 ? ? ? ? 
4 non-polymer syn 'MAGNESIUM ION'            24.305    1 ? ? ? ? 
5 non-polymer syn "ADENOSINE-5'-DIPHOSPHATE" 427.201   1 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'   no no 
;MDETDEDEFTPRPYQVELLERAMKKNTIVCLGTGSGKTFIAVMLIKELAHEIRGPFNEGGKRTFFLVNTVPLVNQQAKVI
RKHTSLKVGEYVGDMGVDSWNKEKWNQEFEKHQVLVMTAQIFLDILNHGFISLSQVNLLIFDECHHAVKNHPYRQIMRHY
KNLEQNDRPRILGLTASVINSKCKPNQVEKKIKELEATLNSRVVTASDLEEVAVQKYATKPKEIIVSYNSDRKSDTSEVI
ENIINQALEQLSNIEETSNLNDTNSLKQIKKVLRDIKNILDELGPWCAHRVIKSRIRQLEKRESETAEELRTIRELLQSI
FEQIINVLKNLEKLQKNNSVEFVSPKVKKLLEILKQYFSNNNNSSKELCGIIFVERRYTAYVLYKLLNELSAKRDDDFSF
IKCDFVVGHNSSPSSKEKSTEMNSKKQKEVLKKFRKGECNLLVATSVVEEGIDIPKCNLVVRFDLPKNFRSYVQSKGRAR
AKNSKYIIMVEEDEKNKFQEDLNQYQEIEKILLRLCHNRDAPSEEDFDSFEDELLPPYMPYGTDGPRVTMSSAISLLHRY
CSKLPSDRFTTLTPKFTYIEQNNEEENKMFRCTLRLPINSPLREPITGQPMPSKKLAKRSAALEACKKLHEMGELDDHLL
PVKISRKNAELK
;
;MDETDEDEFTPRPYQVELLERAMKKNTIVCLGTGSGKTFIAVMLIKELAHEIRGPFNEGGKRTFFLVNTVPLVNQQAKVI
RKHTSLKVGEYVGDMGVDSWNKEKWNQEFEKHQVLVMTAQIFLDILNHGFISLSQVNLLIFDECHHAVKNHPYRQIMRHY
KNLEQNDRPRILGLTASVINSKCKPNQVEKKIKELEATLNSRVVTASDLEEVAVQKYATKPKEIIVSYNSDRKSDTSEVI
ENIINQALEQLSNIEETSNLNDTNSLKQIKKVLRDIKNILDELGPWCAHRVIKSRIRQLEKRESETAEELRTIRELLQSI
FEQIINVLKNLEKLQKNNSVEFVSPKVKKLLEILKQYFSNNNNSSKELCGIIFVERRYTAYVLYKLLNELSAKRDDDFSF
IKCDFVVGHNSSPSSKEKSTEMNSKKQKEVLKKFRKGECNLLVATSVVEEGIDIPKCNLVVRFDLPKNFRSYVQSKGRAR
AKNSKYIIMVEEDEKNKFQEDLNQYQEIEKILLRLCHNRDAPSEEDFDSFEDELLPPYMPYGTDGPRVTMSSAISLLHRY
CSKLPSDRFTTLTPKFTYIEQNNEEENKMFRCTLRLPINSPLREPITGQPMPSKKLAKRSAALEACKKLHEMGELDDHLL
PVKISRKNAELK
;
A ? 
2 polyribonucleotide no no AUACGUCCUGAUAGUUAGUAUCCAUCG AUACGUCCUGAUAGUUAGUAUCCAUCG B ? 
3 polyribonucleotide no no CGAUGGAUACUAACUAUCAGGACGUAU CGAUGGAUACUAACUAUCAGGACGUAU C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'MAGNESIUM ION'            MG  
5 "ADENOSINE-5'-DIPHOSPHATE" ADP 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   GLU n 
1 4   THR n 
1 5   ASP n 
1 6   GLU n 
1 7   ASP n 
1 8   GLU n 
1 9   PHE n 
1 10  THR n 
1 11  PRO n 
1 12  ARG n 
1 13  PRO n 
1 14  TYR n 
1 15  GLN n 
1 16  VAL n 
1 17  GLU n 
1 18  LEU n 
1 19  LEU n 
1 20  GLU n 
1 21  ARG n 
1 22  ALA n 
1 23  MET n 
1 24  LYS n 
1 25  LYS n 
1 26  ASN n 
1 27  THR n 
1 28  ILE n 
1 29  VAL n 
1 30  CYS n 
1 31  LEU n 
1 32  GLY n 
1 33  THR n 
1 34  GLY n 
1 35  SER n 
1 36  GLY n 
1 37  LYS n 
1 38  THR n 
1 39  PHE n 
1 40  ILE n 
1 41  ALA n 
1 42  VAL n 
1 43  MET n 
1 44  LEU n 
1 45  ILE n 
1 46  LYS n 
1 47  GLU n 
1 48  LEU n 
1 49  ALA n 
1 50  HIS n 
1 51  GLU n 
1 52  ILE n 
1 53  ARG n 
1 54  GLY n 
1 55  PRO n 
1 56  PHE n 
1 57  ASN n 
1 58  GLU n 
1 59  GLY n 
1 60  GLY n 
1 61  LYS n 
1 62  ARG n 
1 63  THR n 
1 64  PHE n 
1 65  PHE n 
1 66  LEU n 
1 67  VAL n 
1 68  ASN n 
1 69  THR n 
1 70  VAL n 
1 71  PRO n 
1 72  LEU n 
1 73  VAL n 
1 74  ASN n 
1 75  GLN n 
1 76  GLN n 
1 77  ALA n 
1 78  LYS n 
1 79  VAL n 
1 80  ILE n 
1 81  ARG n 
1 82  LYS n 
1 83  HIS n 
1 84  THR n 
1 85  SER n 
1 86  LEU n 
1 87  LYS n 
1 88  VAL n 
1 89  GLY n 
1 90  GLU n 
1 91  TYR n 
1 92  VAL n 
1 93  GLY n 
1 94  ASP n 
1 95  MET n 
1 96  GLY n 
1 97  VAL n 
1 98  ASP n 
1 99  SER n 
1 100 TRP n 
1 101 ASN n 
1 102 LYS n 
1 103 GLU n 
1 104 LYS n 
1 105 TRP n 
1 106 ASN n 
1 107 GLN n 
1 108 GLU n 
1 109 PHE n 
1 110 GLU n 
1 111 LYS n 
1 112 HIS n 
1 113 GLN n 
1 114 VAL n 
1 115 LEU n 
1 116 VAL n 
1 117 MET n 
1 118 THR n 
1 119 ALA n 
1 120 GLN n 
1 121 ILE n 
1 122 PHE n 
1 123 LEU n 
1 124 ASP n 
1 125 ILE n 
1 126 LEU n 
1 127 ASN n 
1 128 HIS n 
1 129 GLY n 
1 130 PHE n 
1 131 ILE n 
1 132 SER n 
1 133 LEU n 
1 134 SER n 
1 135 GLN n 
1 136 VAL n 
1 137 ASN n 
1 138 LEU n 
1 139 LEU n 
1 140 ILE n 
1 141 PHE n 
1 142 ASP n 
1 143 GLU n 
1 144 CYS n 
1 145 HIS n 
1 146 HIS n 
1 147 ALA n 
1 148 VAL n 
1 149 LYS n 
1 150 ASN n 
1 151 HIS n 
1 152 PRO n 
1 153 TYR n 
1 154 ARG n 
1 155 GLN n 
1 156 ILE n 
1 157 MET n 
1 158 ARG n 
1 159 HIS n 
1 160 TYR n 
1 161 LYS n 
1 162 ASN n 
1 163 LEU n 
1 164 GLU n 
1 165 GLN n 
1 166 ASN n 
1 167 ASP n 
1 168 ARG n 
1 169 PRO n 
1 170 ARG n 
1 171 ILE n 
1 172 LEU n 
1 173 GLY n 
1 174 LEU n 
1 175 THR n 
1 176 ALA n 
1 177 SER n 
1 178 VAL n 
1 179 ILE n 
1 180 ASN n 
1 181 SER n 
1 182 LYS n 
1 183 CYS n 
1 184 LYS n 
1 185 PRO n 
1 186 ASN n 
1 187 GLN n 
1 188 VAL n 
1 189 GLU n 
1 190 LYS n 
1 191 LYS n 
1 192 ILE n 
1 193 LYS n 
1 194 GLU n 
1 195 LEU n 
1 196 GLU n 
1 197 ALA n 
1 198 THR n 
1 199 LEU n 
1 200 ASN n 
1 201 SER n 
1 202 ARG n 
1 203 VAL n 
1 204 VAL n 
1 205 THR n 
1 206 ALA n 
1 207 SER n 
1 208 ASP n 
1 209 LEU n 
1 210 GLU n 
1 211 GLU n 
1 212 VAL n 
1 213 ALA n 
1 214 VAL n 
1 215 GLN n 
1 216 LYS n 
1 217 TYR n 
1 218 ALA n 
1 219 THR n 
1 220 LYS n 
1 221 PRO n 
1 222 LYS n 
1 223 GLU n 
1 224 ILE n 
1 225 ILE n 
1 226 VAL n 
1 227 SER n 
1 228 TYR n 
1 229 ASN n 
1 230 SER n 
1 231 ASP n 
1 232 ARG n 
1 233 LYS n 
1 234 SER n 
1 235 ASP n 
1 236 THR n 
1 237 SER n 
1 238 GLU n 
1 239 VAL n 
1 240 ILE n 
1 241 GLU n 
1 242 ASN n 
1 243 ILE n 
1 244 ILE n 
1 245 ASN n 
1 246 GLN n 
1 247 ALA n 
1 248 LEU n 
1 249 GLU n 
1 250 GLN n 
1 251 LEU n 
1 252 SER n 
1 253 ASN n 
1 254 ILE n 
1 255 GLU n 
1 256 GLU n 
1 257 THR n 
1 258 SER n 
1 259 ASN n 
1 260 LEU n 
1 261 ASN n 
1 262 ASP n 
1 263 THR n 
1 264 ASN n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 GLN n 
1 269 ILE n 
1 270 LYS n 
1 271 LYS n 
1 272 VAL n 
1 273 LEU n 
1 274 ARG n 
1 275 ASP n 
1 276 ILE n 
1 277 LYS n 
1 278 ASN n 
1 279 ILE n 
1 280 LEU n 
1 281 ASP n 
1 282 GLU n 
1 283 LEU n 
1 284 GLY n 
1 285 PRO n 
1 286 TRP n 
1 287 CYS n 
1 288 ALA n 
1 289 HIS n 
1 290 ARG n 
1 291 VAL n 
1 292 ILE n 
1 293 LYS n 
1 294 SER n 
1 295 ARG n 
1 296 ILE n 
1 297 ARG n 
1 298 GLN n 
1 299 LEU n 
1 300 GLU n 
1 301 LYS n 
1 302 ARG n 
1 303 GLU n 
1 304 SER n 
1 305 GLU n 
1 306 THR n 
1 307 ALA n 
1 308 GLU n 
1 309 GLU n 
1 310 LEU n 
1 311 ARG n 
1 312 THR n 
1 313 ILE n 
1 314 ARG n 
1 315 GLU n 
1 316 LEU n 
1 317 LEU n 
1 318 GLN n 
1 319 SER n 
1 320 ILE n 
1 321 PHE n 
1 322 GLU n 
1 323 GLN n 
1 324 ILE n 
1 325 ILE n 
1 326 ASN n 
1 327 VAL n 
1 328 LEU n 
1 329 LYS n 
1 330 ASN n 
1 331 LEU n 
1 332 GLU n 
1 333 LYS n 
1 334 LEU n 
1 335 GLN n 
1 336 LYS n 
1 337 ASN n 
1 338 ASN n 
1 339 SER n 
1 340 VAL n 
1 341 GLU n 
1 342 PHE n 
1 343 VAL n 
1 344 SER n 
1 345 PRO n 
1 346 LYS n 
1 347 VAL n 
1 348 LYS n 
1 349 LYS n 
1 350 LEU n 
1 351 LEU n 
1 352 GLU n 
1 353 ILE n 
1 354 LEU n 
1 355 LYS n 
1 356 GLN n 
1 357 TYR n 
1 358 PHE n 
1 359 SER n 
1 360 ASN n 
1 361 ASN n 
1 362 ASN n 
1 363 ASN n 
1 364 SER n 
1 365 SER n 
1 366 LYS n 
1 367 GLU n 
1 368 LEU n 
1 369 CYS n 
1 370 GLY n 
1 371 ILE n 
1 372 ILE n 
1 373 PHE n 
1 374 VAL n 
1 375 GLU n 
1 376 ARG n 
1 377 ARG n 
1 378 TYR n 
1 379 THR n 
1 380 ALA n 
1 381 TYR n 
1 382 VAL n 
1 383 LEU n 
1 384 TYR n 
1 385 LYS n 
1 386 LEU n 
1 387 LEU n 
1 388 ASN n 
1 389 GLU n 
1 390 LEU n 
1 391 SER n 
1 392 ALA n 
1 393 LYS n 
1 394 ARG n 
1 395 ASP n 
1 396 ASP n 
1 397 ASP n 
1 398 PHE n 
1 399 SER n 
1 400 PHE n 
1 401 ILE n 
1 402 LYS n 
1 403 CYS n 
1 404 ASP n 
1 405 PHE n 
1 406 VAL n 
1 407 VAL n 
1 408 GLY n 
1 409 HIS n 
1 410 ASN n 
1 411 SER n 
1 412 SER n 
1 413 PRO n 
1 414 SER n 
1 415 SER n 
1 416 LYS n 
1 417 GLU n 
1 418 LYS n 
1 419 SER n 
1 420 THR n 
1 421 GLU n 
1 422 MET n 
1 423 ASN n 
1 424 SER n 
1 425 LYS n 
1 426 LYS n 
1 427 GLN n 
1 428 LYS n 
1 429 GLU n 
1 430 VAL n 
1 431 LEU n 
1 432 LYS n 
1 433 LYS n 
1 434 PHE n 
1 435 ARG n 
1 436 LYS n 
1 437 GLY n 
1 438 GLU n 
1 439 CYS n 
1 440 ASN n 
1 441 LEU n 
1 442 LEU n 
1 443 VAL n 
1 444 ALA n 
1 445 THR n 
1 446 SER n 
1 447 VAL n 
1 448 VAL n 
1 449 GLU n 
1 450 GLU n 
1 451 GLY n 
1 452 ILE n 
1 453 ASP n 
1 454 ILE n 
1 455 PRO n 
1 456 LYS n 
1 457 CYS n 
1 458 ASN n 
1 459 LEU n 
1 460 VAL n 
1 461 VAL n 
1 462 ARG n 
1 463 PHE n 
1 464 ASP n 
1 465 LEU n 
1 466 PRO n 
1 467 LYS n 
1 468 ASN n 
1 469 PHE n 
1 470 ARG n 
1 471 SER n 
1 472 TYR n 
1 473 VAL n 
1 474 GLN n 
1 475 SER n 
1 476 LYS n 
1 477 GLY n 
1 478 ARG n 
1 479 ALA n 
1 480 ARG n 
1 481 ALA n 
1 482 LYS n 
1 483 ASN n 
1 484 SER n 
1 485 LYS n 
1 486 TYR n 
1 487 ILE n 
1 488 ILE n 
1 489 MET n 
1 490 VAL n 
1 491 GLU n 
1 492 GLU n 
1 493 ASP n 
1 494 GLU n 
1 495 LYS n 
1 496 ASN n 
1 497 LYS n 
1 498 PHE n 
1 499 GLN n 
1 500 GLU n 
1 501 ASP n 
1 502 LEU n 
1 503 ASN n 
1 504 GLN n 
1 505 TYR n 
1 506 GLN n 
1 507 GLU n 
1 508 ILE n 
1 509 GLU n 
1 510 LYS n 
1 511 ILE n 
1 512 LEU n 
1 513 LEU n 
1 514 ARG n 
1 515 LEU n 
1 516 CYS n 
1 517 HIS n 
1 518 ASN n 
1 519 ARG n 
1 520 ASP n 
1 521 ALA n 
1 522 PRO n 
1 523 SER n 
1 524 GLU n 
1 525 GLU n 
1 526 ASP n 
1 527 PHE n 
1 528 ASP n 
1 529 SER n 
1 530 PHE n 
1 531 GLU n 
1 532 ASP n 
1 533 GLU n 
1 534 LEU n 
1 535 LEU n 
1 536 PRO n 
1 537 PRO n 
1 538 TYR n 
1 539 MET n 
1 540 PRO n 
1 541 TYR n 
1 542 GLY n 
1 543 THR n 
1 544 ASP n 
1 545 GLY n 
1 546 PRO n 
1 547 ARG n 
1 548 VAL n 
1 549 THR n 
1 550 MET n 
1 551 SER n 
1 552 SER n 
1 553 ALA n 
1 554 ILE n 
1 555 SER n 
1 556 LEU n 
1 557 LEU n 
1 558 HIS n 
1 559 ARG n 
1 560 TYR n 
1 561 CYS n 
1 562 SER n 
1 563 LYS n 
1 564 LEU n 
1 565 PRO n 
1 566 SER n 
1 567 ASP n 
1 568 ARG n 
1 569 PHE n 
1 570 THR n 
1 571 THR n 
1 572 LEU n 
1 573 THR n 
1 574 PRO n 
1 575 LYS n 
1 576 PHE n 
1 577 THR n 
1 578 TYR n 
1 579 ILE n 
1 580 GLU n 
1 581 GLN n 
1 582 ASN n 
1 583 ASN n 
1 584 GLU n 
1 585 GLU n 
1 586 GLU n 
1 587 ASN n 
1 588 LYS n 
1 589 MET n 
1 590 PHE n 
1 591 ARG n 
1 592 CYS n 
1 593 THR n 
1 594 LEU n 
1 595 ARG n 
1 596 LEU n 
1 597 PRO n 
1 598 ILE n 
1 599 ASN n 
1 600 SER n 
1 601 PRO n 
1 602 LEU n 
1 603 ARG n 
1 604 GLU n 
1 605 PRO n 
1 606 ILE n 
1 607 THR n 
1 608 GLY n 
1 609 GLN n 
1 610 PRO n 
1 611 MET n 
1 612 PRO n 
1 613 SER n 
1 614 LYS n 
1 615 LYS n 
1 616 LEU n 
1 617 ALA n 
1 618 LYS n 
1 619 ARG n 
1 620 SER n 
1 621 ALA n 
1 622 ALA n 
1 623 LEU n 
1 624 GLU n 
1 625 ALA n 
1 626 CYS n 
1 627 LYS n 
1 628 LYS n 
1 629 LEU n 
1 630 HIS n 
1 631 GLU n 
1 632 MET n 
1 633 GLY n 
1 634 GLU n 
1 635 LEU n 
1 636 ASP n 
1 637 ASP n 
1 638 HIS n 
1 639 LEU n 
1 640 LEU n 
1 641 PRO n 
1 642 VAL n 
1 643 LYS n 
1 644 ILE n 
1 645 SER n 
1 646 ARG n 
1 647 LYS n 
1 648 ASN n 
1 649 ALA n 
1 650 GLU n 
1 651 LEU n 
1 652 LYS n 
2 1   A   n 
2 2   U   n 
2 3   A   n 
2 4   C   n 
2 5   G   n 
2 6   U   n 
2 7   C   n 
2 8   C   n 
2 9   U   n 
2 10  G   n 
2 11  A   n 
2 12  U   n 
2 13  A   n 
2 14  G   n 
2 15  U   n 
2 16  U   n 
2 17  A   n 
2 18  G   n 
2 19  U   n 
2 20  A   n 
2 21  U   n 
2 22  C   n 
2 23  C   n 
2 24  A   n 
2 25  U   n 
2 26  C   n 
2 27  G   n 
3 1   C   n 
3 2   G   n 
3 3   A   n 
3 4   U   n 
3 5   G   n 
3 6   G   n 
3 7   A   n 
3 8   U   n 
3 9   A   n 
3 10  C   n 
3 11  U   n 
3 12  A   n 
3 13  A   n 
3 14  C   n 
3 15  U   n 
3 16  A   n 
3 17  U   n 
3 18  C   n 
3 19  A   n 
3 20  G   n 
3 21  G   n 
3 22  A   n 
3 23  C   n 
3 24  G   n 
3 25  U   n 
3 26  A   n 
3 27  U   n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 652 ? ? ? ? ? ? ? ? ? 'synthetic construct' 32630 ? ? ? ? ? ? ? 'fall armyworm' 
'Spodoptera frugiperda' 7108  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 27  ? ? ? ? ? ? ? ? ? 'synthetic construct' 32630 ? ? ? ? ? ? ? ?               
'synthetic construct'   32630 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 27  ? ? ? ? ? ? ? ? ? 'synthetic construct' 32630 ? ? ? ? ? ? ? ?               
'synthetic construct'   32630 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P'   347.221 
ADP non-polymer         n "ADENOSINE-5'-DIPHOSPHATE"   ? 'C10 H15 N5 O10 P2' 427.201 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'        133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O8 P'    323.197 
CYS 'L-peptide linking' y CYSTEINE                     ? 'C3 H7 N O2 S'      121.158 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O8 P'   363.221 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'    156.162 
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'     149.211 
MG  non-polymer         . 'MAGNESIUM ION'              ? 'Mg 2'              24.305  
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'       181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"   ? 'C9 H13 N2 O9 P'    324.181 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   GLU 3   3   ?   ?   ?   A . n 
A 1 4   THR 4   4   ?   ?   ?   A . n 
A 1 5   ASP 5   5   ?   ?   ?   A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   ASP 7   7   7   ASP ASP A . n 
A 1 8   GLU 8   8   8   GLU GLU A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  THR 10  10  10  THR THR A . n 
A 1 11  PRO 11  11  11  PRO PRO A . n 
A 1 12  ARG 12  12  12  ARG ARG A . n 
A 1 13  PRO 13  13  13  PRO PRO A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  GLN 15  15  15  GLN GLN A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  GLU 17  17  17  GLU GLU A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  GLU 20  20  20  GLU GLU A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  MET 23  23  23  MET MET A . n 
A 1 24  LYS 24  24  24  LYS LYS A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  THR 27  27  27  THR THR A . n 
A 1 28  ILE 28  28  28  ILE ILE A . n 
A 1 29  VAL 29  29  29  VAL VAL A . n 
A 1 30  CYS 30  30  30  CYS CYS A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  GLY 32  32  32  GLY GLY A . n 
A 1 33  THR 33  33  33  THR THR A . n 
A 1 34  GLY 34  34  34  GLY GLY A . n 
A 1 35  SER 35  35  35  SER SER A . n 
A 1 36  GLY 36  36  36  GLY GLY A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  THR 38  38  38  THR THR A . n 
A 1 39  PHE 39  39  39  PHE PHE A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  MET 43  43  43  MET MET A . n 
A 1 44  LEU 44  44  44  LEU LEU A . n 
A 1 45  ILE 45  45  45  ILE ILE A . n 
A 1 46  LYS 46  46  46  LYS LYS A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  HIS 50  50  50  HIS HIS A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  ARG 53  53  53  ARG ARG A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  PRO 55  55  55  PRO PRO A . n 
A 1 56  PHE 56  56  56  PHE PHE A . n 
A 1 57  ASN 57  57  57  ASN ASN A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  ARG 62  62  62  ARG ARG A . n 
A 1 63  THR 63  63  63  THR THR A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  PHE 65  65  65  PHE PHE A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  VAL 67  67  67  VAL VAL A . n 
A 1 68  ASN 68  68  68  ASN ASN A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  VAL 70  70  70  VAL VAL A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  GLN 76  76  76  GLN GLN A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ARG 81  81  81  ARG ARG A . n 
A 1 82  LYS 82  82  82  LYS LYS A . n 
A 1 83  HIS 83  83  83  HIS HIS A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  SER 85  85  85  SER SER A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  GLU 90  90  90  GLU GLU A . n 
A 1 91  TYR 91  91  91  TYR TYR A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  GLY 93  93  93  GLY GLY A . n 
A 1 94  ASP 94  94  94  ASP ASP A . n 
A 1 95  MET 95  95  95  MET MET A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  SER 99  99  99  SER SER A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 ASN 101 101 101 ASN ASN A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 TRP 105 105 105 TRP TRP A . n 
A 1 106 ASN 106 106 106 ASN ASN A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 GLU 108 108 108 GLU GLU A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 GLU 110 110 110 GLU GLU A . n 
A 1 111 LYS 111 111 111 LYS LYS A . n 
A 1 112 HIS 112 112 112 HIS HIS A . n 
A 1 113 GLN 113 113 113 GLN GLN A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 MET 117 117 117 MET MET A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 PHE 122 122 122 PHE PHE A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 ASP 124 124 124 ASP ASP A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 ASN 127 127 127 ASN ASN A . n 
A 1 128 HIS 128 128 128 HIS HIS A . n 
A 1 129 GLY 129 129 129 GLY GLY A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 SER 134 134 134 SER SER A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 VAL 136 136 136 VAL VAL A . n 
A 1 137 ASN 137 137 137 ASN ASN A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 PHE 141 141 141 PHE PHE A . n 
A 1 142 ASP 142 142 142 ASP ASP A . n 
A 1 143 GLU 143 143 143 GLU GLU A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 HIS 145 145 145 HIS HIS A . n 
A 1 146 HIS 146 146 146 HIS HIS A . n 
A 1 147 ALA 147 147 147 ALA ALA A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 HIS 151 151 151 HIS HIS A . n 
A 1 152 PRO 152 152 152 PRO PRO A . n 
A 1 153 TYR 153 153 153 TYR TYR A . n 
A 1 154 ARG 154 154 154 ARG ARG A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 ILE 156 156 156 ILE ILE A . n 
A 1 157 MET 157 157 157 MET MET A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 HIS 159 159 159 HIS HIS A . n 
A 1 160 TYR 160 160 160 TYR TYR A . n 
A 1 161 LYS 161 161 161 LYS LYS A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 GLU 164 164 164 GLU GLU A . n 
A 1 165 GLN 165 165 165 GLN GLN A . n 
A 1 166 ASN 166 166 166 ASN ASN A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 ILE 179 179 179 ILE ILE A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 SER 181 181 181 SER SER A . n 
A 1 182 LYS 182 182 182 LYS LYS A . n 
A 1 183 CYS 183 183 183 CYS CYS A . n 
A 1 184 LYS 184 184 184 LYS LYS A . n 
A 1 185 PRO 185 185 185 PRO PRO A . n 
A 1 186 ASN 186 186 186 ASN ASN A . n 
A 1 187 GLN 187 187 187 GLN GLN A . n 
A 1 188 VAL 188 188 188 VAL VAL A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ILE 192 192 192 ILE ILE A . n 
A 1 193 LYS 193 193 193 LYS LYS A . n 
A 1 194 GLU 194 194 194 GLU GLU A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 GLU 196 196 196 GLU GLU A . n 
A 1 197 ALA 197 197 197 ALA ALA A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 ASN 200 200 200 ASN ASN A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 VAL 203 203 203 VAL VAL A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 ASP 208 208 208 ASP ASP A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 GLU 210 210 210 GLU GLU A . n 
A 1 211 GLU 211 211 211 GLU GLU A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 VAL 214 214 214 VAL VAL A . n 
A 1 215 GLN 215 215 215 GLN GLN A . n 
A 1 216 LYS 216 216 216 LYS LYS A . n 
A 1 217 TYR 217 217 217 TYR TYR A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 THR 219 219 219 THR THR A . n 
A 1 220 LYS 220 220 220 LYS LYS A . n 
A 1 221 PRO 221 221 221 PRO PRO A . n 
A 1 222 LYS 222 222 222 LYS LYS A . n 
A 1 223 GLU 223 223 223 GLU GLU A . n 
A 1 224 ILE 224 224 224 ILE ILE A . n 
A 1 225 ILE 225 225 225 ILE ILE A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 TYR 228 228 228 TYR TYR A . n 
A 1 229 ASN 229 229 229 ASN ASN A . n 
A 1 230 SER 230 230 230 SER SER A . n 
A 1 231 ASP 231 231 231 ASP ASP A . n 
A 1 232 ARG 232 232 232 ARG ARG A . n 
A 1 233 LYS 233 233 233 LYS LYS A . n 
A 1 234 SER 234 234 234 SER SER A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 THR 236 236 236 THR THR A . n 
A 1 237 SER 237 237 237 SER SER A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 ILE 240 240 240 ILE ILE A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 ASN 242 242 242 ASN ASN A . n 
A 1 243 ILE 243 243 243 ILE ILE A . n 
A 1 244 ILE 244 244 244 ILE ILE A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 GLN 246 246 246 GLN GLN A . n 
A 1 247 ALA 247 247 247 ALA ALA A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 GLU 249 249 249 GLU GLU A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 SER 252 252 252 SER SER A . n 
A 1 253 ASN 253 253 253 ASN ASN A . n 
A 1 254 ILE 254 254 254 ILE ILE A . n 
A 1 255 GLU 255 255 255 GLU GLU A . n 
A 1 256 GLU 256 256 256 GLU GLU A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 ASN 259 259 259 ASN ASN A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 ASN 261 261 261 ASN ASN A . n 
A 1 262 ASP 262 262 262 ASP ASP A . n 
A 1 263 THR 263 263 263 THR THR A . n 
A 1 264 ASN 264 264 264 ASN ASN A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 LYS 267 267 267 LYS LYS A . n 
A 1 268 GLN 268 268 268 GLN GLN A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 LYS 270 270 270 LYS LYS A . n 
A 1 271 LYS 271 271 271 LYS LYS A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 ARG 274 274 274 ARG ARG A . n 
A 1 275 ASP 275 275 275 ASP ASP A . n 
A 1 276 ILE 276 276 276 ILE ILE A . n 
A 1 277 LYS 277 277 277 LYS LYS A . n 
A 1 278 ASN 278 278 278 ASN ASN A . n 
A 1 279 ILE 279 279 279 ILE ILE A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 GLU 282 282 282 GLU GLU A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 TRP 286 286 286 TRP TRP A . n 
A 1 287 CYS 287 287 287 CYS CYS A . n 
A 1 288 ALA 288 288 288 ALA ALA A . n 
A 1 289 HIS 289 289 289 HIS HIS A . n 
A 1 290 ARG 290 290 290 ARG ARG A . n 
A 1 291 VAL 291 291 291 VAL VAL A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 LYS 293 293 293 LYS LYS A . n 
A 1 294 SER 294 294 294 SER SER A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 ILE 296 296 296 ILE ILE A . n 
A 1 297 ARG 297 297 297 ARG ARG A . n 
A 1 298 GLN 298 298 298 GLN GLN A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 GLU 300 300 300 GLU GLU A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 ARG 302 302 302 ARG ARG A . n 
A 1 303 GLU 303 303 303 GLU GLU A . n 
A 1 304 SER 304 304 304 SER SER A . n 
A 1 305 GLU 305 305 305 GLU GLU A . n 
A 1 306 THR 306 306 306 THR THR A . n 
A 1 307 ALA 307 307 307 ALA ALA A . n 
A 1 308 GLU 308 308 308 GLU GLU A . n 
A 1 309 GLU 309 309 309 GLU GLU A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 ARG 311 311 311 ARG ARG A . n 
A 1 312 THR 312 312 312 THR THR A . n 
A 1 313 ILE 313 313 313 ILE ILE A . n 
A 1 314 ARG 314 314 314 ARG ARG A . n 
A 1 315 GLU 315 315 315 GLU GLU A . n 
A 1 316 LEU 316 316 316 LEU LEU A . n 
A 1 317 LEU 317 317 317 LEU LEU A . n 
A 1 318 GLN 318 318 318 GLN GLN A . n 
A 1 319 SER 319 319 319 SER SER A . n 
A 1 320 ILE 320 320 320 ILE ILE A . n 
A 1 321 PHE 321 321 321 PHE PHE A . n 
A 1 322 GLU 322 322 322 GLU GLU A . n 
A 1 323 GLN 323 323 323 GLN GLN A . n 
A 1 324 ILE 324 324 324 ILE ILE A . n 
A 1 325 ILE 325 325 325 ILE ILE A . n 
A 1 326 ASN 326 326 326 ASN ASN A . n 
A 1 327 VAL 327 327 327 VAL VAL A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 LYS 329 329 329 LYS LYS A . n 
A 1 330 ASN 330 330 330 ASN ASN A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 GLU 332 332 332 GLU GLU A . n 
A 1 333 LYS 333 333 333 LYS LYS A . n 
A 1 334 LEU 334 334 334 LEU LEU A . n 
A 1 335 GLN 335 335 335 GLN GLN A . n 
A 1 336 LYS 336 336 336 LYS LYS A . n 
A 1 337 ASN 337 337 337 ASN ASN A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 SER 339 339 339 SER SER A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 GLU 341 341 341 GLU GLU A . n 
A 1 342 PHE 342 342 342 PHE PHE A . n 
A 1 343 VAL 343 343 343 VAL VAL A . n 
A 1 344 SER 344 344 344 SER SER A . n 
A 1 345 PRO 345 345 345 PRO PRO A . n 
A 1 346 LYS 346 346 346 LYS LYS A . n 
A 1 347 VAL 347 347 347 VAL VAL A . n 
A 1 348 LYS 348 348 348 LYS LYS A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 LEU 350 350 350 LEU LEU A . n 
A 1 351 LEU 351 351 351 LEU LEU A . n 
A 1 352 GLU 352 352 352 GLU GLU A . n 
A 1 353 ILE 353 353 353 ILE ILE A . n 
A 1 354 LEU 354 354 354 LEU LEU A . n 
A 1 355 LYS 355 355 355 LYS LYS A . n 
A 1 356 GLN 356 356 356 GLN GLN A . n 
A 1 357 TYR 357 357 357 TYR TYR A . n 
A 1 358 PHE 358 358 358 PHE PHE A . n 
A 1 359 SER 359 359 359 SER SER A . n 
A 1 360 ASN 360 360 360 ASN ASN A . n 
A 1 361 ASN 361 361 361 ASN ASN A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ASN 363 363 363 ASN ASN A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 SER 365 365 365 SER SER A . n 
A 1 366 LYS 366 366 366 LYS LYS A . n 
A 1 367 GLU 367 367 367 GLU GLU A . n 
A 1 368 LEU 368 368 368 LEU LEU A . n 
A 1 369 CYS 369 369 369 CYS CYS A . n 
A 1 370 GLY 370 370 370 GLY GLY A . n 
A 1 371 ILE 371 371 371 ILE ILE A . n 
A 1 372 ILE 372 372 372 ILE ILE A . n 
A 1 373 PHE 373 373 373 PHE PHE A . n 
A 1 374 VAL 374 374 374 VAL VAL A . n 
A 1 375 GLU 375 375 375 GLU GLU A . n 
A 1 376 ARG 376 376 376 ARG ARG A . n 
A 1 377 ARG 377 377 377 ARG ARG A . n 
A 1 378 TYR 378 378 378 TYR TYR A . n 
A 1 379 THR 379 379 379 THR THR A . n 
A 1 380 ALA 380 380 380 ALA ALA A . n 
A 1 381 TYR 381 381 381 TYR TYR A . n 
A 1 382 VAL 382 382 382 VAL VAL A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 TYR 384 384 384 TYR TYR A . n 
A 1 385 LYS 385 385 385 LYS LYS A . n 
A 1 386 LEU 386 386 386 LEU LEU A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 ASN 388 388 388 ASN ASN A . n 
A 1 389 GLU 389 389 389 GLU GLU A . n 
A 1 390 LEU 390 390 390 LEU LEU A . n 
A 1 391 SER 391 391 391 SER SER A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 LYS 393 393 393 LYS LYS A . n 
A 1 394 ARG 394 394 394 ARG ARG A . n 
A 1 395 ASP 395 395 395 ASP ASP A . n 
A 1 396 ASP 396 396 396 ASP ASP A . n 
A 1 397 ASP 397 397 397 ASP ASP A . n 
A 1 398 PHE 398 398 398 PHE PHE A . n 
A 1 399 SER 399 399 399 SER SER A . n 
A 1 400 PHE 400 400 400 PHE PHE A . n 
A 1 401 ILE 401 401 401 ILE ILE A . n 
A 1 402 LYS 402 402 402 LYS LYS A . n 
A 1 403 CYS 403 403 403 CYS CYS A . n 
A 1 404 ASP 404 404 404 ASP ASP A . n 
A 1 405 PHE 405 405 405 PHE PHE A . n 
A 1 406 VAL 406 406 406 VAL VAL A . n 
A 1 407 VAL 407 407 407 VAL VAL A . n 
A 1 408 GLY 408 408 408 GLY GLY A . n 
A 1 409 HIS 409 409 409 HIS HIS A . n 
A 1 410 ASN 410 410 410 ASN ASN A . n 
A 1 411 SER 411 411 411 SER SER A . n 
A 1 412 SER 412 412 412 SER SER A . n 
A 1 413 PRO 413 413 413 PRO PRO A . n 
A 1 414 SER 414 414 414 SER SER A . n 
A 1 415 SER 415 415 415 SER SER A . n 
A 1 416 LYS 416 416 416 LYS LYS A . n 
A 1 417 GLU 417 417 417 GLU GLU A . n 
A 1 418 LYS 418 418 418 LYS LYS A . n 
A 1 419 SER 419 419 419 SER SER A . n 
A 1 420 THR 420 420 420 THR THR A . n 
A 1 421 GLU 421 421 421 GLU GLU A . n 
A 1 422 MET 422 422 422 MET MET A . n 
A 1 423 ASN 423 423 423 ASN ASN A . n 
A 1 424 SER 424 424 424 SER SER A . n 
A 1 425 LYS 425 425 425 LYS LYS A . n 
A 1 426 LYS 426 426 426 LYS LYS A . n 
A 1 427 GLN 427 427 427 GLN GLN A . n 
A 1 428 LYS 428 428 428 LYS LYS A . n 
A 1 429 GLU 429 429 429 GLU GLU A . n 
A 1 430 VAL 430 430 430 VAL VAL A . n 
A 1 431 LEU 431 431 431 LEU LEU A . n 
A 1 432 LYS 432 432 432 LYS LYS A . n 
A 1 433 LYS 433 433 433 LYS LYS A . n 
A 1 434 PHE 434 434 434 PHE PHE A . n 
A 1 435 ARG 435 435 435 ARG ARG A . n 
A 1 436 LYS 436 436 436 LYS LYS A . n 
A 1 437 GLY 437 437 437 GLY GLY A . n 
A 1 438 GLU 438 438 438 GLU GLU A . n 
A 1 439 CYS 439 439 439 CYS CYS A . n 
A 1 440 ASN 440 440 440 ASN ASN A . n 
A 1 441 LEU 441 441 441 LEU LEU A . n 
A 1 442 LEU 442 442 442 LEU LEU A . n 
A 1 443 VAL 443 443 443 VAL VAL A . n 
A 1 444 ALA 444 444 444 ALA ALA A . n 
A 1 445 THR 445 445 445 THR THR A . n 
A 1 446 SER 446 446 446 SER SER A . n 
A 1 447 VAL 447 447 447 VAL VAL A . n 
A 1 448 VAL 448 448 448 VAL VAL A . n 
A 1 449 GLU 449 449 449 GLU GLU A . n 
A 1 450 GLU 450 450 450 GLU GLU A . n 
A 1 451 GLY 451 451 451 GLY GLY A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 ASP 453 453 453 ASP ASP A . n 
A 1 454 ILE 454 454 454 ILE ILE A . n 
A 1 455 PRO 455 455 455 PRO PRO A . n 
A 1 456 LYS 456 456 456 LYS LYS A . n 
A 1 457 CYS 457 457 457 CYS CYS A . n 
A 1 458 ASN 458 458 458 ASN ASN A . n 
A 1 459 LEU 459 459 459 LEU LEU A . n 
A 1 460 VAL 460 460 460 VAL VAL A . n 
A 1 461 VAL 461 461 461 VAL VAL A . n 
A 1 462 ARG 462 462 462 ARG ARG A . n 
A 1 463 PHE 463 463 463 PHE PHE A . n 
A 1 464 ASP 464 464 464 ASP ASP A . n 
A 1 465 LEU 465 465 465 LEU LEU A . n 
A 1 466 PRO 466 466 466 PRO PRO A . n 
A 1 467 LYS 467 467 467 LYS LYS A . n 
A 1 468 ASN 468 468 468 ASN ASN A . n 
A 1 469 PHE 469 469 469 PHE PHE A . n 
A 1 470 ARG 470 470 470 ARG ARG A . n 
A 1 471 SER 471 471 471 SER SER A . n 
A 1 472 TYR 472 472 472 TYR TYR A . n 
A 1 473 VAL 473 473 473 VAL VAL A . n 
A 1 474 GLN 474 474 474 GLN GLN A . n 
A 1 475 SER 475 475 475 SER SER A . n 
A 1 476 LYS 476 476 476 LYS LYS A . n 
A 1 477 GLY 477 477 477 GLY GLY A . n 
A 1 478 ARG 478 478 478 ARG ARG A . n 
A 1 479 ALA 479 479 479 ALA ALA A . n 
A 1 480 ARG 480 480 480 ARG ARG A . n 
A 1 481 ALA 481 481 481 ALA ALA A . n 
A 1 482 LYS 482 482 482 LYS LYS A . n 
A 1 483 ASN 483 483 483 ASN ASN A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 LYS 485 485 485 LYS LYS A . n 
A 1 486 TYR 486 486 486 TYR TYR A . n 
A 1 487 ILE 487 487 487 ILE ILE A . n 
A 1 488 ILE 488 488 488 ILE ILE A . n 
A 1 489 MET 489 489 489 MET MET A . n 
A 1 490 VAL 490 490 490 VAL VAL A . n 
A 1 491 GLU 491 491 491 GLU GLU A . n 
A 1 492 GLU 492 492 492 GLU GLU A . n 
A 1 493 ASP 493 493 493 ASP ASP A . n 
A 1 494 GLU 494 494 494 GLU GLU A . n 
A 1 495 LYS 495 495 495 LYS LYS A . n 
A 1 496 ASN 496 496 496 ASN ASN A . n 
A 1 497 LYS 497 497 497 LYS LYS A . n 
A 1 498 PHE 498 498 498 PHE PHE A . n 
A 1 499 GLN 499 499 499 GLN GLN A . n 
A 1 500 GLU 500 500 500 GLU GLU A . n 
A 1 501 ASP 501 501 501 ASP ASP A . n 
A 1 502 LEU 502 502 502 LEU LEU A . n 
A 1 503 ASN 503 503 503 ASN ASN A . n 
A 1 504 GLN 504 504 504 GLN GLN A . n 
A 1 505 TYR 505 505 505 TYR TYR A . n 
A 1 506 GLN 506 506 506 GLN GLN A . n 
A 1 507 GLU 507 507 507 GLU GLU A . n 
A 1 508 ILE 508 508 508 ILE ILE A . n 
A 1 509 GLU 509 509 509 GLU GLU A . n 
A 1 510 LYS 510 510 510 LYS LYS A . n 
A 1 511 ILE 511 511 511 ILE ILE A . n 
A 1 512 LEU 512 512 512 LEU LEU A . n 
A 1 513 LEU 513 513 513 LEU LEU A . n 
A 1 514 ARG 514 514 514 ARG ARG A . n 
A 1 515 LEU 515 515 515 LEU LEU A . n 
A 1 516 CYS 516 516 516 CYS CYS A . n 
A 1 517 HIS 517 517 517 HIS HIS A . n 
A 1 518 ASN 518 518 518 ASN ASN A . n 
A 1 519 ARG 519 519 519 ARG ARG A . n 
A 1 520 ASP 520 520 520 ASP ASP A . n 
A 1 521 ALA 521 521 521 ALA ALA A . n 
A 1 522 PRO 522 522 522 PRO PRO A . n 
A 1 523 SER 523 523 523 SER SER A . n 
A 1 524 GLU 524 524 524 GLU GLU A . n 
A 1 525 GLU 525 525 525 GLU GLU A . n 
A 1 526 ASP 526 526 526 ASP ASP A . n 
A 1 527 PHE 527 527 527 PHE PHE A . n 
A 1 528 ASP 528 528 528 ASP ASP A . n 
A 1 529 SER 529 529 529 SER SER A . n 
A 1 530 PHE 530 530 530 PHE PHE A . n 
A 1 531 GLU 531 531 531 GLU GLU A . n 
A 1 532 ASP 532 532 532 ASP ASP A . n 
A 1 533 GLU 533 533 533 GLU GLU A . n 
A 1 534 LEU 534 534 534 LEU LEU A . n 
A 1 535 LEU 535 535 535 LEU LEU A . n 
A 1 536 PRO 536 536 536 PRO PRO A . n 
A 1 537 PRO 537 537 537 PRO PRO A . n 
A 1 538 TYR 538 538 538 TYR TYR A . n 
A 1 539 MET 539 539 539 MET MET A . n 
A 1 540 PRO 540 540 540 PRO PRO A . n 
A 1 541 TYR 541 541 541 TYR TYR A . n 
A 1 542 GLY 542 542 542 GLY GLY A . n 
A 1 543 THR 543 543 543 THR THR A . n 
A 1 544 ASP 544 544 544 ASP ASP A . n 
A 1 545 GLY 545 545 545 GLY GLY A . n 
A 1 546 PRO 546 546 546 PRO PRO A . n 
A 1 547 ARG 547 547 547 ARG ARG A . n 
A 1 548 VAL 548 548 548 VAL VAL A . n 
A 1 549 THR 549 549 549 THR THR A . n 
A 1 550 MET 550 550 550 MET MET A . n 
A 1 551 SER 551 551 551 SER SER A . n 
A 1 552 SER 552 552 552 SER SER A . n 
A 1 553 ALA 553 553 553 ALA ALA A . n 
A 1 554 ILE 554 554 554 ILE ILE A . n 
A 1 555 SER 555 555 555 SER SER A . n 
A 1 556 LEU 556 556 556 LEU LEU A . n 
A 1 557 LEU 557 557 557 LEU LEU A . n 
A 1 558 HIS 558 558 558 HIS HIS A . n 
A 1 559 ARG 559 559 559 ARG ARG A . n 
A 1 560 TYR 560 560 560 TYR TYR A . n 
A 1 561 CYS 561 561 561 CYS CYS A . n 
A 1 562 SER 562 562 562 SER SER A . n 
A 1 563 LYS 563 563 563 LYS LYS A . n 
A 1 564 LEU 564 564 564 LEU LEU A . n 
A 1 565 PRO 565 565 565 PRO PRO A . n 
A 1 566 SER 566 566 566 SER SER A . n 
A 1 567 ASP 567 567 567 ASP ASP A . n 
A 1 568 ARG 568 568 568 ARG ARG A . n 
A 1 569 PHE 569 569 569 PHE PHE A . n 
A 1 570 THR 570 570 570 THR THR A . n 
A 1 571 THR 571 571 571 THR THR A . n 
A 1 572 LEU 572 572 572 LEU LEU A . n 
A 1 573 THR 573 573 573 THR THR A . n 
A 1 574 PRO 574 574 574 PRO PRO A . n 
A 1 575 LYS 575 575 575 LYS LYS A . n 
A 1 576 PHE 576 576 576 PHE PHE A . n 
A 1 577 THR 577 577 577 THR THR A . n 
A 1 578 TYR 578 578 578 TYR TYR A . n 
A 1 579 ILE 579 579 579 ILE ILE A . n 
A 1 580 GLU 580 580 580 GLU GLU A . n 
A 1 581 GLN 581 581 581 GLN GLN A . n 
A 1 582 ASN 582 582 582 ASN ASN A . n 
A 1 583 ASN 583 583 583 ASN ASN A . n 
A 1 584 GLU 584 584 584 GLU GLU A . n 
A 1 585 GLU 585 585 585 GLU GLU A . n 
A 1 586 GLU 586 586 586 GLU GLU A . n 
A 1 587 ASN 587 587 587 ASN ASN A . n 
A 1 588 LYS 588 588 588 LYS LYS A . n 
A 1 589 MET 589 589 589 MET MET A . n 
A 1 590 PHE 590 590 590 PHE PHE A . n 
A 1 591 ARG 591 591 591 ARG ARG A . n 
A 1 592 CYS 592 592 592 CYS CYS A . n 
A 1 593 THR 593 593 593 THR THR A . n 
A 1 594 LEU 594 594 594 LEU LEU A . n 
A 1 595 ARG 595 595 595 ARG ARG A . n 
A 1 596 LEU 596 596 596 LEU LEU A . n 
A 1 597 PRO 597 597 597 PRO PRO A . n 
A 1 598 ILE 598 598 598 ILE ILE A . n 
A 1 599 ASN 599 599 599 ASN ASN A . n 
A 1 600 SER 600 600 600 SER SER A . n 
A 1 601 PRO 601 601 601 PRO PRO A . n 
A 1 602 LEU 602 602 602 LEU LEU A . n 
A 1 603 ARG 603 603 603 ARG ARG A . n 
A 1 604 GLU 604 604 604 GLU GLU A . n 
A 1 605 PRO 605 605 605 PRO PRO A . n 
A 1 606 ILE 606 606 606 ILE ILE A . n 
A 1 607 THR 607 607 607 THR THR A . n 
A 1 608 GLY 608 608 608 GLY GLY A . n 
A 1 609 GLN 609 609 609 GLN GLN A . n 
A 1 610 PRO 610 610 610 PRO PRO A . n 
A 1 611 MET 611 611 611 MET MET A . n 
A 1 612 PRO 612 612 612 PRO PRO A . n 
A 1 613 SER 613 613 613 SER SER A . n 
A 1 614 LYS 614 614 614 LYS LYS A . n 
A 1 615 LYS 615 615 615 LYS LYS A . n 
A 1 616 LEU 616 616 616 LEU LEU A . n 
A 1 617 ALA 617 617 617 ALA ALA A . n 
A 1 618 LYS 618 618 618 LYS LYS A . n 
A 1 619 ARG 619 619 619 ARG ARG A . n 
A 1 620 SER 620 620 620 SER SER A . n 
A 1 621 ALA 621 621 621 ALA ALA A . n 
A 1 622 ALA 622 622 622 ALA ALA A . n 
A 1 623 LEU 623 623 623 LEU LEU A . n 
A 1 624 GLU 624 624 624 GLU GLU A . n 
A 1 625 ALA 625 625 625 ALA ALA A . n 
A 1 626 CYS 626 626 626 CYS CYS A . n 
A 1 627 LYS 627 627 627 LYS LYS A . n 
A 1 628 LYS 628 628 628 LYS LYS A . n 
A 1 629 LEU 629 629 629 LEU LEU A . n 
A 1 630 HIS 630 630 630 HIS HIS A . n 
A 1 631 GLU 631 631 631 GLU GLU A . n 
A 1 632 MET 632 632 632 MET MET A . n 
A 1 633 GLY 633 633 633 GLY GLY A . n 
A 1 634 GLU 634 634 634 GLU GLU A . n 
A 1 635 LEU 635 635 635 LEU LEU A . n 
A 1 636 ASP 636 636 636 ASP ASP A . n 
A 1 637 ASP 637 637 637 ASP ASP A . n 
A 1 638 HIS 638 638 638 HIS HIS A . n 
A 1 639 LEU 639 639 639 LEU LEU A . n 
A 1 640 LEU 640 640 640 LEU LEU A . n 
A 1 641 PRO 641 641 641 PRO PRO A . n 
A 1 642 VAL 642 642 642 VAL VAL A . n 
A 1 643 LYS 643 643 643 LYS LYS A . n 
A 1 644 ILE 644 644 644 ILE ILE A . n 
A 1 645 SER 645 645 645 SER SER A . n 
A 1 646 ARG 646 646 646 ARG ARG A . n 
A 1 647 LYS 647 647 647 LYS LYS A . n 
A 1 648 ASN 648 648 648 ASN ASN A . n 
A 1 649 ALA 649 649 649 ALA ALA A . n 
A 1 650 GLU 650 650 650 GLU GLU A . n 
A 1 651 LEU 651 651 651 LEU LEU A . n 
A 1 652 LYS 652 652 652 LYS LYS A . n 
B 2 1   A   1   1   1   A   A   B . n 
B 2 2   U   2   2   2   U   U   B . n 
B 2 3   A   3   3   3   A   A   B . n 
B 2 4   C   4   4   4   C   C   B . n 
B 2 5   G   5   5   5   G   G   B . n 
B 2 6   U   6   6   6   U   U   B . n 
B 2 7   C   7   7   7   C   C   B . n 
B 2 8   C   8   8   8   C   C   B . n 
B 2 9   U   9   9   9   U   U   B . n 
B 2 10  G   10  10  10  G   G   B . n 
B 2 11  A   11  11  11  A   A   B . n 
B 2 12  U   12  12  12  U   U   B . n 
B 2 13  A   13  13  13  A   A   B . n 
B 2 14  G   14  14  14  G   G   B . n 
B 2 15  U   15  15  15  U   U   B . n 
B 2 16  U   16  16  16  U   U   B . n 
B 2 17  A   17  17  17  A   A   B . n 
B 2 18  G   18  18  18  G   G   B . n 
B 2 19  U   19  19  19  U   U   B . n 
B 2 20  A   20  20  20  A   A   B . n 
B 2 21  U   21  21  21  U   U   B . n 
B 2 22  C   22  22  22  C   C   B . n 
B 2 23  C   23  23  23  C   C   B . n 
B 2 24  A   24  24  24  A   A   B . n 
B 2 25  U   25  25  25  U   U   B . n 
B 2 26  C   26  26  26  C   C   B . n 
B 2 27  G   27  27  27  G   G   B . n 
C 3 1   C   1   1   1   C   C   C . n 
C 3 2   G   2   2   2   G   G   C . n 
C 3 3   A   3   3   3   A   A   C . n 
C 3 4   U   4   4   4   U   U   C . n 
C 3 5   G   5   5   5   G   G   C . n 
C 3 6   G   6   6   6   G   G   C . n 
C 3 7   A   7   7   7   A   A   C . n 
C 3 8   U   8   8   8   U   U   C . n 
C 3 9   A   9   9   9   A   A   C . n 
C 3 10  C   10  10  10  C   C   C . n 
C 3 11  U   11  11  11  U   U   C . n 
C 3 12  A   12  12  12  A   A   C . n 
C 3 13  A   13  13  13  A   A   C . n 
C 3 14  C   14  14  14  C   C   C . n 
C 3 15  U   15  15  15  U   U   C . n 
C 3 16  A   16  16  16  A   A   C . n 
C 3 17  U   17  17  17  U   U   C . n 
C 3 18  C   18  18  18  C   C   C . n 
C 3 19  A   19  19  19  A   A   C . n 
C 3 20  G   20  20  20  G   G   C . n 
C 3 21  G   21  21  21  G   G   C . n 
C 3 22  A   22  22  22  A   A   C . n 
C 3 23  C   23  23  23  C   C   C . n 
C 3 24  G   24  24  24  G   G   C . n 
C 3 25  U   25  25  25  U   U   C . n 
C 3 26  A   26  26  26  A   A   C . n 
C 3 27  U   27  27  27  U   U   C . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 ADP ? ? ADP ? ? 'SUBJECT OF INVESTIGATION' ? 
2 MG  ? ? MG  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 MG  1 701 1   MG  MG  A . 
E 5 ADP 1 702 701 ADP ADP A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MW8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MW8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MW8 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9MW8 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002  ? 6640 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.605  ? 9206 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 14.201 ? 1460 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.036  ? 1078 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 984  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9MW8 
_struct.title                        
'Cryo-EM structure of ancestral Dicer helicase bound to 27-bp dsRNA in post-hydrolysis closed state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MW8 
_struct_keywords.text            'RNA helicase, dsRBM, ANTIVIRAL PROTEIN-RNA complex' 
_struct_keywords.pdbx_keywords   'ANTIVIRAL PROTEIN/RNA' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9MW8 9MW8 ? 1 ? 1 
2 PDB 9MW8 9MW8 ? 2 ? 1 
3 PDB 9MW8 9MW8 ? 3 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9MW8 A 1 ? 652 ? 9MW8 1 ? 652 ? 1 652 
2 2 9MW8 B 1 ? 27  ? 9MW8 1 ? 27  ? 1 27  
3 3 9MW8 C 1 ? 27  ? 9MW8 1 ? 27  ? 1 27  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 12  ? LYS A 25  ? ARG A 12  LYS A 25  1 ? 14 
HELX_P HELX_P2  AA2 GLY A 36  ? LEU A 48  ? GLY A 36  LEU A 48  1 ? 13 
HELX_P HELX_P3  AA3 HIS A 50  ? GLY A 54  ? HIS A 50  GLY A 54  5 ? 5  
HELX_P HELX_P4  AA4 VAL A 70  ? THR A 84  ? VAL A 70  THR A 84  1 ? 15 
HELX_P HELX_P5  AA5 VAL A 92  ? TRP A 100 ? VAL A 92  TRP A 100 5 ? 9  
HELX_P HELX_P6  AA6 ASN A 101 ? HIS A 112 ? ASN A 101 HIS A 112 1 ? 12 
HELX_P HELX_P7  AA7 ALA A 119 ? HIS A 128 ? ALA A 119 HIS A 128 1 ? 10 
HELX_P HELX_P8  AA8 SER A 132 ? SER A 134 ? SER A 132 SER A 134 5 ? 3  
HELX_P HELX_P9  AA9 CYS A 144 ? ALA A 147 ? CYS A 144 ALA A 147 5 ? 4  
HELX_P HELX_P10 AB1 HIS A 151 ? ASN A 162 ? HIS A 151 ASN A 162 1 ? 12 
HELX_P HELX_P11 AB2 ASN A 186 ? ASN A 200 ? ASN A 186 ASN A 200 1 ? 15 
HELX_P HELX_P12 AB3 ALA A 206 ? GLU A 211 ? ALA A 206 GLU A 211 1 ? 6  
HELX_P HELX_P13 AB4 VAL A 212 ? ALA A 218 ? VAL A 212 ALA A 218 1 ? 7  
HELX_P HELX_P14 AB5 SER A 234 ? SER A 258 ? SER A 234 SER A 258 1 ? 25 
HELX_P HELX_P15 AB6 ASP A 262 ? LEU A 283 ? ASP A 262 LEU A 283 1 ? 22 
HELX_P HELX_P16 AB7 GLY A 284 ? GLU A 303 ? GLY A 284 GLU A 303 1 ? 20 
HELX_P HELX_P17 AB8 ALA A 307 ? LEU A 331 ? ALA A 307 LEU A 331 1 ? 25 
HELX_P HELX_P18 AB9 SER A 344 ? ASN A 362 ? SER A 344 ASN A 362 1 ? 19 
HELX_P HELX_P19 AC1 ARG A 376 ? LYS A 393 ? ARG A 376 LYS A 393 1 ? 18 
HELX_P HELX_P20 AC2 ASP A 395 ? PHE A 400 ? ASP A 395 PHE A 400 1 ? 6  
HELX_P HELX_P21 AC3 ASN A 423 ? GLY A 437 ? ASN A 423 GLY A 437 1 ? 15 
HELX_P HELX_P22 AC4 THR A 445 ? GLU A 450 ? THR A 445 GLU A 450 1 ? 6  
HELX_P HELX_P23 AC5 ASN A 468 ? ARG A 478 ? ASN A 468 ARG A 478 1 ? 11 
HELX_P HELX_P24 AC6 GLU A 494 ? CYS A 516 ? GLU A 494 CYS A 516 1 ? 23 
HELX_P HELX_P25 AC7 SER A 523 ? PHE A 530 ? SER A 523 PHE A 530 1 ? 8  
HELX_P HELX_P26 AC8 THR A 549 ? LEU A 564 ? THR A 549 LEU A 564 1 ? 16 
HELX_P HELX_P27 AC9 SER A 613 ? GLY A 633 ? SER A 613 GLY A 633 1 ? 21 
HELX_P HELX_P28 AD1 SER A 645 ? LYS A 652 ? SER A 645 LYS A 652 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
hydrog1  hydrog ? ? B A 1  N1 ? ? ? 1_555 C U 27 N3 ? ? B A 1  C U 27 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog2  hydrog ? ? B A 1  N6 ? ? ? 1_555 C U 27 O4 ? ? B A 1  C U 27 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog3  hydrog ? ? B U 2  N3 ? ? ? 1_555 C A 26 N1 ? ? B U 2  C A 26 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog4  hydrog ? ? B U 2  O4 ? ? ? 1_555 C A 26 N6 ? ? B U 2  C A 26 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog5  hydrog ? ? B A 3  N1 ? ? ? 1_555 C U 25 N3 ? ? B A 3  C U 25 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog6  hydrog ? ? B A 3  N6 ? ? ? 1_555 C U 25 O4 ? ? B A 3  C U 25 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog7  hydrog ? ? B C 4  N3 ? ? ? 1_555 C G 24 N1 ? ? B C 4  C G 24 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog8  hydrog ? ? B C 4  N4 ? ? ? 1_555 C G 24 O6 ? ? B C 4  C G 24 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog9  hydrog ? ? B C 4  O2 ? ? ? 1_555 C G 24 N2 ? ? B C 4  C G 24 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog10 hydrog ? ? B G 5  N1 ? ? ? 1_555 C C 23 N3 ? ? B G 5  C C 23 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog11 hydrog ? ? B G 5  N2 ? ? ? 1_555 C C 23 O2 ? ? B G 5  C C 23 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog12 hydrog ? ? B G 5  O6 ? ? ? 1_555 C C 23 N4 ? ? B G 5  C C 23 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog13 hydrog ? ? B U 6  N3 ? ? ? 1_555 C A 22 N1 ? ? B U 6  C A 22 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog14 hydrog ? ? B U 6  O4 ? ? ? 1_555 C A 22 N6 ? ? B U 6  C A 22 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog15 hydrog ? ? B C 7  N3 ? ? ? 1_555 C G 21 N1 ? ? B C 7  C G 21 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog16 hydrog ? ? B C 7  N4 ? ? ? 1_555 C G 21 O6 ? ? B C 7  C G 21 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog17 hydrog ? ? B C 7  O2 ? ? ? 1_555 C G 21 N2 ? ? B C 7  C G 21 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog18 hydrog ? ? B C 8  N3 ? ? ? 1_555 C G 20 N1 ? ? B C 8  C G 20 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog19 hydrog ? ? B C 8  N4 ? ? ? 1_555 C G 20 O6 ? ? B C 8  C G 20 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog20 hydrog ? ? B C 8  O2 ? ? ? 1_555 C G 20 N2 ? ? B C 8  C G 20 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog21 hydrog ? ? B U 9  N3 ? ? ? 1_555 C A 19 N1 ? ? B U 9  C A 19 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog22 hydrog ? ? B U 9  O4 ? ? ? 1_555 C A 19 N6 ? ? B U 9  C A 19 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog23 hydrog ? ? B G 10 N1 ? ? ? 1_555 C C 18 N3 ? ? B G 10 C C 18 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog24 hydrog ? ? B G 10 N2 ? ? ? 1_555 C C 18 O2 ? ? B G 10 C C 18 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog25 hydrog ? ? B G 10 O6 ? ? ? 1_555 C C 18 N4 ? ? B G 10 C C 18 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog26 hydrog ? ? B A 11 N1 ? ? ? 1_555 C U 17 N3 ? ? B A 11 C U 17 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog27 hydrog ? ? B A 11 N6 ? ? ? 1_555 C U 17 O4 ? ? B A 11 C U 17 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog28 hydrog ? ? B U 12 N3 ? ? ? 1_555 C A 16 N1 ? ? B U 12 C A 16 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog29 hydrog ? ? B U 12 O4 ? ? ? 1_555 C A 16 N6 ? ? B U 12 C A 16 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog30 hydrog ? ? B A 13 N1 ? ? ? 1_555 C U 15 N3 ? ? B A 13 C U 15 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog31 hydrog ? ? B A 13 N6 ? ? ? 1_555 C U 15 O4 ? ? B A 13 C U 15 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog32 hydrog ? ? B G 14 N1 ? ? ? 1_555 C C 14 N3 ? ? B G 14 C C 14 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog33 hydrog ? ? B G 14 N2 ? ? ? 1_555 C C 14 O2 ? ? B G 14 C C 14 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog34 hydrog ? ? B G 14 O6 ? ? ? 1_555 C C 14 N4 ? ? B G 14 C C 14 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog35 hydrog ? ? B U 15 N3 ? ? ? 1_555 C A 13 N1 ? ? B U 15 C A 13 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog36 hydrog ? ? B U 15 O4 ? ? ? 1_555 C A 13 N6 ? ? B U 15 C A 13 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog37 hydrog ? ? B U 16 N3 ? ? ? 1_555 C A 12 N1 ? ? B U 16 C A 12 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog38 hydrog ? ? B U 16 O4 ? ? ? 1_555 C A 12 N6 ? ? B U 16 C A 12 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog39 hydrog ? ? B A 17 N1 ? ? ? 1_555 C U 11 N3 ? ? B A 17 C U 11 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog40 hydrog ? ? B A 17 N6 ? ? ? 1_555 C U 11 O4 ? ? B A 17 C U 11 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog41 hydrog ? ? B G 18 N1 ? ? ? 1_555 C C 10 N3 ? ? B G 18 C C 10 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog42 hydrog ? ? B G 18 N2 ? ? ? 1_555 C C 10 O2 ? ? B G 18 C C 10 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog43 hydrog ? ? B G 18 O6 ? ? ? 1_555 C C 10 N4 ? ? B G 18 C C 10 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog44 hydrog ? ? B U 19 N3 ? ? ? 1_555 C A 9  N1 ? ? B U 19 C A 9  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog45 hydrog ? ? B U 19 O4 ? ? ? 1_555 C A 9  N6 ? ? B U 19 C A 9  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog46 hydrog ? ? B A 20 N1 ? ? ? 1_555 C U 8  N3 ? ? B A 20 C U 8  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog47 hydrog ? ? B A 20 N6 ? ? ? 1_555 C U 8  O4 ? ? B A 20 C U 8  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog48 hydrog ? ? B U 21 N3 ? ? ? 1_555 C A 7  N1 ? ? B U 21 C A 7  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog49 hydrog ? ? B U 21 O4 ? ? ? 1_555 C A 7  N6 ? ? B U 21 C A 7  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog50 hydrog ? ? B C 22 N3 ? ? ? 1_555 C G 6  N1 ? ? B C 22 C G 6  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog51 hydrog ? ? B C 22 N4 ? ? ? 1_555 C G 6  O6 ? ? B C 22 C G 6  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog52 hydrog ? ? B C 22 O2 ? ? ? 1_555 C G 6  N2 ? ? B C 22 C G 6  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog53 hydrog ? ? B C 23 N3 ? ? ? 1_555 C G 5  N1 ? ? B C 23 C G 5  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog54 hydrog ? ? B C 23 N4 ? ? ? 1_555 C G 5  O6 ? ? B C 23 C G 5  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog55 hydrog ? ? B C 23 O2 ? ? ? 1_555 C G 5  N2 ? ? B C 23 C G 5  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog56 hydrog ? ? B A 24 N1 ? ? ? 1_555 C U 4  N3 ? ? B A 24 C U 4  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog57 hydrog ? ? B A 24 N6 ? ? ? 1_555 C U 4  O4 ? ? B A 24 C U 4  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog58 hydrog ? ? B U 25 N3 ? ? ? 1_555 C A 3  N1 ? ? B U 25 C A 3  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog59 hydrog ? ? B U 25 O4 ? ? ? 1_555 C A 3  N6 ? ? B U 25 C A 3  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog60 hydrog ? ? B C 26 N3 ? ? ? 1_555 C G 2  N1 ? ? B C 26 C G 2  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog61 hydrog ? ? B C 26 N4 ? ? ? 1_555 C G 2  O6 ? ? B C 26 C G 2  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog62 hydrog ? ? B C 26 O2 ? ? ? 1_555 C G 2  N2 ? ? B C 26 C G 2  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog63 hydrog ? ? B G 27 N1 ? ? ? 1_555 C C 1  N3 ? ? B G 27 C C 1  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog64 hydrog ? ? B G 27 N2 ? ? ? 1_555 C C 1  O2 ? ? B G 27 C C 1  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog65 hydrog ? ? B G 27 O6 ? ? ? 1_555 C C 1  N4 ? ? B G 27 C C 1  1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
# 
_struct_conn_type.id          hydrog 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 6 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 88  ? GLU A 90  ? VAL A 88  GLU A 90  
AA1 2 VAL A 114 ? THR A 118 ? VAL A 114 THR A 118 
AA1 3 ARG A 62  ? VAL A 67  ? ARG A 62  VAL A 67  
AA1 4 VAL A 136 ? ASP A 142 ? VAL A 136 ASP A 142 
AA1 5 ARG A 170 ? THR A 175 ? ARG A 170 THR A 175 
AA1 6 THR A 27  ? CYS A 30  ? THR A 27  CYS A 30  
AA1 7 ARG A 202 ? VAL A 204 ? ARG A 202 VAL A 204 
AA2 1 LYS A 222 ? TYR A 228 ? LYS A 222 TYR A 228 
AA2 2 LYS A 485 ? GLU A 491 ? LYS A 485 GLU A 491 
AA2 3 LEU A 459 ? ARG A 462 ? LEU A 459 ARG A 462 
AA2 4 GLY A 370 ? PHE A 373 ? GLY A 370 PHE A 373 
AA2 5 LEU A 441 ? ALA A 444 ? LEU A 441 ALA A 444 
AA2 6 CYS A 403 ? VAL A 406 ? CYS A 403 VAL A 406 
AA3 1 LYS A 575 ? ASN A 582 ? LYS A 575 ASN A 582 
AA3 2 LYS A 588 ? ARG A 595 ? LYS A 588 ARG A 595 
AA3 3 ILE A 606 ? THR A 607 ? ILE A 606 THR A 607 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 89  ? N GLY A 89  O VAL A 114 ? O VAL A 114 
AA1 2 3 O LEU A 115 ? O LEU A 115 N PHE A 65  ? N PHE A 65  
AA1 3 4 N ARG A 62  ? N ARG A 62  O ASN A 137 ? O ASN A 137 
AA1 4 5 N PHE A 141 ? N PHE A 141 O LEU A 172 ? O LEU A 172 
AA1 5 6 O GLY A 173 ? O GLY A 173 N VAL A 29  ? N VAL A 29  
AA1 6 7 N ILE A 28  ? N ILE A 28  O VAL A 204 ? O VAL A 204 
AA2 1 2 N VAL A 226 ? N VAL A 226 O VAL A 490 ? O VAL A 490 
AA2 2 3 O ILE A 487 ? O ILE A 487 N ARG A 462 ? N ARG A 462 
AA2 3 4 O VAL A 461 ? O VAL A 461 N ILE A 371 ? N ILE A 371 
AA2 4 5 N ILE A 372 ? N ILE A 372 O LEU A 442 ? O LEU A 442 
AA2 5 6 O VAL A 443 ? O VAL A 443 N ASP A 404 ? N ASP A 404 
AA3 1 2 N THR A 577 ? N THR A 577 O THR A 593 ? O THR A 593 
AA3 2 3 N LEU A 594 ? N LEU A 594 O ILE A 606 ? O ILE A 606 
# 
_pdbx_entry_details.entry_id                   9MW8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GLU 
_pdbx_validate_close_contact.auth_seq_id_1    211 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   N 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   ALA 
_pdbx_validate_close_contact.auth_seq_id_2    213 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.17 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              274 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              274 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              274 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                127.22 
_pdbx_validate_rmsd_angle.angle_target_value         113.40 
_pdbx_validate_rmsd_angle.angle_deviation            13.82 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.20 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 CYS A 144 ? ? -69.93 0.18    
2 1 LYS A 149 ? ? 60.21  -106.52 
3 1 VAL A 212 ? ? 45.67  -33.83  
4 1 ARG A 394 ? ? 74.77  -5.95   
5 1 SER A 415 ? ? -62.22 -70.88  
6 1 LYS A 416 ? ? 34.54  57.58   
7 1 PRO A 455 ? ? -59.50 171.08  
8 1 PRO A 597 ? ? -69.05 -176.43 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9MW8 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'FLEXIBLE FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  . 
_em_3d_fitting_list.pdb_chain_id                  . 
_em_3d_fitting_list.pdb_chain_residue_range       . 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   AlphaFold 
_em_3d_fitting_list.type                          'in silico model' 
_em_3d_fitting_list.accession_code                ? 
_em_3d_fitting_list.initial_refinement_model_id   ? 
# 
_em_3d_reconstruction.entry_id                    9MW8 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.3 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               315941 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Ancestral metazoan Dicer helicase in complex 27-bp blunt dsRNA and ATP' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_imaging.entry_id                        9MW8 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2500 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           105000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9MW8 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            'FEI VITROBOT MARK III' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9MW8 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9MW8 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1 ? A MET 1 
2 1 Y 1 A ASP 2 ? A ASP 2 
3 1 Y 1 A GLU 3 ? A GLU 3 
4 1 Y 1 A THR 4 ? A THR 4 
5 1 Y 1 A ASP 5 ? A ASP 5 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O  N N 1   
A   P      P  N N 2   
A   OP1    O  N N 3   
A   OP2    O  N N 4   
A   "O5'"  O  N N 5   
A   "C5'"  C  N N 6   
A   "C4'"  C  N R 7   
A   "O4'"  O  N N 8   
A   "C3'"  C  N S 9   
A   "O3'"  O  N N 10  
A   "C2'"  C  N R 11  
A   "O2'"  O  N N 12  
A   "C1'"  C  N R 13  
A   N9     N  Y N 14  
A   C8     C  Y N 15  
A   N7     N  Y N 16  
A   C5     C  Y N 17  
A   C6     C  Y N 18  
A   N6     N  N N 19  
A   N1     N  Y N 20  
A   C2     C  Y N 21  
A   N3     N  Y N 22  
A   C4     C  Y N 23  
A   HOP3   H  N N 24  
A   HOP2   H  N N 25  
A   "H5'"  H  N N 26  
A   "H5''" H  N N 27  
A   "H4'"  H  N N 28  
A   "H3'"  H  N N 29  
A   "HO3'" H  N N 30  
A   "H2'"  H  N N 31  
A   "HO2'" H  N N 32  
A   "H1'"  H  N N 33  
A   H8     H  N N 34  
A   H61    H  N N 35  
A   H62    H  N N 36  
A   H2     H  N N 37  
ADP PB     P  N N 38  
ADP O1B    O  N N 39  
ADP O2B    O  N N 40  
ADP O3B    O  N N 41  
ADP PA     P  N S 42  
ADP O1A    O  N N 43  
ADP O2A    O  N N 44  
ADP O3A    O  N N 45  
ADP "O5'"  O  N N 46  
ADP "C5'"  C  N N 47  
ADP "C4'"  C  N R 48  
ADP "O4'"  O  N N 49  
ADP "C3'"  C  N S 50  
ADP "O3'"  O  N N 51  
ADP "C2'"  C  N R 52  
ADP "O2'"  O  N N 53  
ADP "C1'"  C  N R 54  
ADP N9     N  Y N 55  
ADP C8     C  Y N 56  
ADP N7     N  Y N 57  
ADP C5     C  Y N 58  
ADP C6     C  Y N 59  
ADP N6     N  N N 60  
ADP N1     N  Y N 61  
ADP C2     C  Y N 62  
ADP N3     N  Y N 63  
ADP C4     C  Y N 64  
ADP HOB2   H  N N 65  
ADP HOB3   H  N N 66  
ADP HOA2   H  N N 67  
ADP "H5'1" H  N N 68  
ADP "H5'2" H  N N 69  
ADP "H4'"  H  N N 70  
ADP "H3'"  H  N N 71  
ADP "HO3'" H  N N 72  
ADP "H2'"  H  N N 73  
ADP "HO2'" H  N N 74  
ADP "H1'"  H  N N 75  
ADP H8     H  N N 76  
ADP HN61   H  N N 77  
ADP HN62   H  N N 78  
ADP H2     H  N N 79  
ALA N      N  N N 80  
ALA CA     C  N S 81  
ALA C      C  N N 82  
ALA O      O  N N 83  
ALA CB     C  N N 84  
ALA OXT    O  N N 85  
ALA H      H  N N 86  
ALA H2     H  N N 87  
ALA HA     H  N N 88  
ALA HB1    H  N N 89  
ALA HB2    H  N N 90  
ALA HB3    H  N N 91  
ALA HXT    H  N N 92  
ARG N      N  N N 93  
ARG CA     C  N S 94  
ARG C      C  N N 95  
ARG O      O  N N 96  
ARG CB     C  N N 97  
ARG CG     C  N N 98  
ARG CD     C  N N 99  
ARG NE     N  N N 100 
ARG CZ     C  N N 101 
ARG NH1    N  N N 102 
ARG NH2    N  N N 103 
ARG OXT    O  N N 104 
ARG H      H  N N 105 
ARG H2     H  N N 106 
ARG HA     H  N N 107 
ARG HB2    H  N N 108 
ARG HB3    H  N N 109 
ARG HG2    H  N N 110 
ARG HG3    H  N N 111 
ARG HD2    H  N N 112 
ARG HD3    H  N N 113 
ARG HE     H  N N 114 
ARG HH11   H  N N 115 
ARG HH12   H  N N 116 
ARG HH21   H  N N 117 
ARG HH22   H  N N 118 
ARG HXT    H  N N 119 
ASN N      N  N N 120 
ASN CA     C  N S 121 
ASN C      C  N N 122 
ASN O      O  N N 123 
ASN CB     C  N N 124 
ASN CG     C  N N 125 
ASN OD1    O  N N 126 
ASN ND2    N  N N 127 
ASN OXT    O  N N 128 
ASN H      H  N N 129 
ASN H2     H  N N 130 
ASN HA     H  N N 131 
ASN HB2    H  N N 132 
ASN HB3    H  N N 133 
ASN HD21   H  N N 134 
ASN HD22   H  N N 135 
ASN HXT    H  N N 136 
ASP N      N  N N 137 
ASP CA     C  N S 138 
ASP C      C  N N 139 
ASP O      O  N N 140 
ASP CB     C  N N 141 
ASP CG     C  N N 142 
ASP OD1    O  N N 143 
ASP OD2    O  N N 144 
ASP OXT    O  N N 145 
ASP H      H  N N 146 
ASP H2     H  N N 147 
ASP HA     H  N N 148 
ASP HB2    H  N N 149 
ASP HB3    H  N N 150 
ASP HD2    H  N N 151 
ASP HXT    H  N N 152 
C   OP3    O  N N 153 
C   P      P  N N 154 
C   OP1    O  N N 155 
C   OP2    O  N N 156 
C   "O5'"  O  N N 157 
C   "C5'"  C  N N 158 
C   "C4'"  C  N R 159 
C   "O4'"  O  N N 160 
C   "C3'"  C  N S 161 
C   "O3'"  O  N N 162 
C   "C2'"  C  N R 163 
C   "O2'"  O  N N 164 
C   "C1'"  C  N R 165 
C   N1     N  N N 166 
C   C2     C  N N 167 
C   O2     O  N N 168 
C   N3     N  N N 169 
C   C4     C  N N 170 
C   N4     N  N N 171 
C   C5     C  N N 172 
C   C6     C  N N 173 
C   HOP3   H  N N 174 
C   HOP2   H  N N 175 
C   "H5'"  H  N N 176 
C   "H5''" H  N N 177 
C   "H4'"  H  N N 178 
C   "H3'"  H  N N 179 
C   "HO3'" H  N N 180 
C   "H2'"  H  N N 181 
C   "HO2'" H  N N 182 
C   "H1'"  H  N N 183 
C   H41    H  N N 184 
C   H42    H  N N 185 
C   H5     H  N N 186 
C   H6     H  N N 187 
CYS N      N  N N 188 
CYS CA     C  N R 189 
CYS C      C  N N 190 
CYS O      O  N N 191 
CYS CB     C  N N 192 
CYS SG     S  N N 193 
CYS OXT    O  N N 194 
CYS H      H  N N 195 
CYS H2     H  N N 196 
CYS HA     H  N N 197 
CYS HB2    H  N N 198 
CYS HB3    H  N N 199 
CYS HG     H  N N 200 
CYS HXT    H  N N 201 
G   OP3    O  N N 202 
G   P      P  N N 203 
G   OP1    O  N N 204 
G   OP2    O  N N 205 
G   "O5'"  O  N N 206 
G   "C5'"  C  N N 207 
G   "C4'"  C  N R 208 
G   "O4'"  O  N N 209 
G   "C3'"  C  N S 210 
G   "O3'"  O  N N 211 
G   "C2'"  C  N R 212 
G   "O2'"  O  N N 213 
G   "C1'"  C  N R 214 
G   N9     N  Y N 215 
G   C8     C  Y N 216 
G   N7     N  Y N 217 
G   C5     C  Y N 218 
G   C6     C  N N 219 
G   O6     O  N N 220 
G   N1     N  N N 221 
G   C2     C  N N 222 
G   N2     N  N N 223 
G   N3     N  N N 224 
G   C4     C  Y N 225 
G   HOP3   H  N N 226 
G   HOP2   H  N N 227 
G   "H5'"  H  N N 228 
G   "H5''" H  N N 229 
G   "H4'"  H  N N 230 
G   "H3'"  H  N N 231 
G   "HO3'" H  N N 232 
G   "H2'"  H  N N 233 
G   "HO2'" H  N N 234 
G   "H1'"  H  N N 235 
G   H8     H  N N 236 
G   H1     H  N N 237 
G   H21    H  N N 238 
G   H22    H  N N 239 
GLN N      N  N N 240 
GLN CA     C  N S 241 
GLN C      C  N N 242 
GLN O      O  N N 243 
GLN CB     C  N N 244 
GLN CG     C  N N 245 
GLN CD     C  N N 246 
GLN OE1    O  N N 247 
GLN NE2    N  N N 248 
GLN OXT    O  N N 249 
GLN H      H  N N 250 
GLN H2     H  N N 251 
GLN HA     H  N N 252 
GLN HB2    H  N N 253 
GLN HB3    H  N N 254 
GLN HG2    H  N N 255 
GLN HG3    H  N N 256 
GLN HE21   H  N N 257 
GLN HE22   H  N N 258 
GLN HXT    H  N N 259 
GLU N      N  N N 260 
GLU CA     C  N S 261 
GLU C      C  N N 262 
GLU O      O  N N 263 
GLU CB     C  N N 264 
GLU CG     C  N N 265 
GLU CD     C  N N 266 
GLU OE1    O  N N 267 
GLU OE2    O  N N 268 
GLU OXT    O  N N 269 
GLU H      H  N N 270 
GLU H2     H  N N 271 
GLU HA     H  N N 272 
GLU HB2    H  N N 273 
GLU HB3    H  N N 274 
GLU HG2    H  N N 275 
GLU HG3    H  N N 276 
GLU HE2    H  N N 277 
GLU HXT    H  N N 278 
GLY N      N  N N 279 
GLY CA     C  N N 280 
GLY C      C  N N 281 
GLY O      O  N N 282 
GLY OXT    O  N N 283 
GLY H      H  N N 284 
GLY H2     H  N N 285 
GLY HA2    H  N N 286 
GLY HA3    H  N N 287 
GLY HXT    H  N N 288 
HIS N      N  N N 289 
HIS CA     C  N S 290 
HIS C      C  N N 291 
HIS O      O  N N 292 
HIS CB     C  N N 293 
HIS CG     C  Y N 294 
HIS ND1    N  Y N 295 
HIS CD2    C  Y N 296 
HIS CE1    C  Y N 297 
HIS NE2    N  Y N 298 
HIS OXT    O  N N 299 
HIS H      H  N N 300 
HIS H2     H  N N 301 
HIS HA     H  N N 302 
HIS HB2    H  N N 303 
HIS HB3    H  N N 304 
HIS HD1    H  N N 305 
HIS HD2    H  N N 306 
HIS HE1    H  N N 307 
HIS HE2    H  N N 308 
HIS HXT    H  N N 309 
ILE N      N  N N 310 
ILE CA     C  N S 311 
ILE C      C  N N 312 
ILE O      O  N N 313 
ILE CB     C  N S 314 
ILE CG1    C  N N 315 
ILE CG2    C  N N 316 
ILE CD1    C  N N 317 
ILE OXT    O  N N 318 
ILE H      H  N N 319 
ILE H2     H  N N 320 
ILE HA     H  N N 321 
ILE HB     H  N N 322 
ILE HG12   H  N N 323 
ILE HG13   H  N N 324 
ILE HG21   H  N N 325 
ILE HG22   H  N N 326 
ILE HG23   H  N N 327 
ILE HD11   H  N N 328 
ILE HD12   H  N N 329 
ILE HD13   H  N N 330 
ILE HXT    H  N N 331 
LEU N      N  N N 332 
LEU CA     C  N S 333 
LEU C      C  N N 334 
LEU O      O  N N 335 
LEU CB     C  N N 336 
LEU CG     C  N N 337 
LEU CD1    C  N N 338 
LEU CD2    C  N N 339 
LEU OXT    O  N N 340 
LEU H      H  N N 341 
LEU H2     H  N N 342 
LEU HA     H  N N 343 
LEU HB2    H  N N 344 
LEU HB3    H  N N 345 
LEU HG     H  N N 346 
LEU HD11   H  N N 347 
LEU HD12   H  N N 348 
LEU HD13   H  N N 349 
LEU HD21   H  N N 350 
LEU HD22   H  N N 351 
LEU HD23   H  N N 352 
LEU HXT    H  N N 353 
LYS N      N  N N 354 
LYS CA     C  N S 355 
LYS C      C  N N 356 
LYS O      O  N N 357 
LYS CB     C  N N 358 
LYS CG     C  N N 359 
LYS CD     C  N N 360 
LYS CE     C  N N 361 
LYS NZ     N  N N 362 
LYS OXT    O  N N 363 
LYS H      H  N N 364 
LYS H2     H  N N 365 
LYS HA     H  N N 366 
LYS HB2    H  N N 367 
LYS HB3    H  N N 368 
LYS HG2    H  N N 369 
LYS HG3    H  N N 370 
LYS HD2    H  N N 371 
LYS HD3    H  N N 372 
LYS HE2    H  N N 373 
LYS HE3    H  N N 374 
LYS HZ1    H  N N 375 
LYS HZ2    H  N N 376 
LYS HZ3    H  N N 377 
LYS HXT    H  N N 378 
MET N      N  N N 379 
MET CA     C  N S 380 
MET C      C  N N 381 
MET O      O  N N 382 
MET CB     C  N N 383 
MET CG     C  N N 384 
MET SD     S  N N 385 
MET CE     C  N N 386 
MET OXT    O  N N 387 
MET H      H  N N 388 
MET H2     H  N N 389 
MET HA     H  N N 390 
MET HB2    H  N N 391 
MET HB3    H  N N 392 
MET HG2    H  N N 393 
MET HG3    H  N N 394 
MET HE1    H  N N 395 
MET HE2    H  N N 396 
MET HE3    H  N N 397 
MET HXT    H  N N 398 
MG  MG     MG N N 399 
PHE N      N  N N 400 
PHE CA     C  N S 401 
PHE C      C  N N 402 
PHE O      O  N N 403 
PHE CB     C  N N 404 
PHE CG     C  Y N 405 
PHE CD1    C  Y N 406 
PHE CD2    C  Y N 407 
PHE CE1    C  Y N 408 
PHE CE2    C  Y N 409 
PHE CZ     C  Y N 410 
PHE OXT    O  N N 411 
PHE H      H  N N 412 
PHE H2     H  N N 413 
PHE HA     H  N N 414 
PHE HB2    H  N N 415 
PHE HB3    H  N N 416 
PHE HD1    H  N N 417 
PHE HD2    H  N N 418 
PHE HE1    H  N N 419 
PHE HE2    H  N N 420 
PHE HZ     H  N N 421 
PHE HXT    H  N N 422 
PRO N      N  N N 423 
PRO CA     C  N S 424 
PRO C      C  N N 425 
PRO O      O  N N 426 
PRO CB     C  N N 427 
PRO CG     C  N N 428 
PRO CD     C  N N 429 
PRO OXT    O  N N 430 
PRO H      H  N N 431 
PRO HA     H  N N 432 
PRO HB2    H  N N 433 
PRO HB3    H  N N 434 
PRO HG2    H  N N 435 
PRO HG3    H  N N 436 
PRO HD2    H  N N 437 
PRO HD3    H  N N 438 
PRO HXT    H  N N 439 
SER N      N  N N 440 
SER CA     C  N S 441 
SER C      C  N N 442 
SER O      O  N N 443 
SER CB     C  N N 444 
SER OG     O  N N 445 
SER OXT    O  N N 446 
SER H      H  N N 447 
SER H2     H  N N 448 
SER HA     H  N N 449 
SER HB2    H  N N 450 
SER HB3    H  N N 451 
SER HG     H  N N 452 
SER HXT    H  N N 453 
THR N      N  N N 454 
THR CA     C  N S 455 
THR C      C  N N 456 
THR O      O  N N 457 
THR CB     C  N R 458 
THR OG1    O  N N 459 
THR CG2    C  N N 460 
THR OXT    O  N N 461 
THR H      H  N N 462 
THR H2     H  N N 463 
THR HA     H  N N 464 
THR HB     H  N N 465 
THR HG1    H  N N 466 
THR HG21   H  N N 467 
THR HG22   H  N N 468 
THR HG23   H  N N 469 
THR HXT    H  N N 470 
TRP N      N  N N 471 
TRP CA     C  N S 472 
TRP C      C  N N 473 
TRP O      O  N N 474 
TRP CB     C  N N 475 
TRP CG     C  Y N 476 
TRP CD1    C  Y N 477 
TRP CD2    C  Y N 478 
TRP NE1    N  Y N 479 
TRP CE2    C  Y N 480 
TRP CE3    C  Y N 481 
TRP CZ2    C  Y N 482 
TRP CZ3    C  Y N 483 
TRP CH2    C  Y N 484 
TRP OXT    O  N N 485 
TRP H      H  N N 486 
TRP H2     H  N N 487 
TRP HA     H  N N 488 
TRP HB2    H  N N 489 
TRP HB3    H  N N 490 
TRP HD1    H  N N 491 
TRP HE1    H  N N 492 
TRP HE3    H  N N 493 
TRP HZ2    H  N N 494 
TRP HZ3    H  N N 495 
TRP HH2    H  N N 496 
TRP HXT    H  N N 497 
TYR N      N  N N 498 
TYR CA     C  N S 499 
TYR C      C  N N 500 
TYR O      O  N N 501 
TYR CB     C  N N 502 
TYR CG     C  Y N 503 
TYR CD1    C  Y N 504 
TYR CD2    C  Y N 505 
TYR CE1    C  Y N 506 
TYR CE2    C  Y N 507 
TYR CZ     C  Y N 508 
TYR OH     O  N N 509 
TYR OXT    O  N N 510 
TYR H      H  N N 511 
TYR H2     H  N N 512 
TYR HA     H  N N 513 
TYR HB2    H  N N 514 
TYR HB3    H  N N 515 
TYR HD1    H  N N 516 
TYR HD2    H  N N 517 
TYR HE1    H  N N 518 
TYR HE2    H  N N 519 
TYR HH     H  N N 520 
TYR HXT    H  N N 521 
U   OP3    O  N N 522 
U   P      P  N N 523 
U   OP1    O  N N 524 
U   OP2    O  N N 525 
U   "O5'"  O  N N 526 
U   "C5'"  C  N N 527 
U   "C4'"  C  N R 528 
U   "O4'"  O  N N 529 
U   "C3'"  C  N S 530 
U   "O3'"  O  N N 531 
U   "C2'"  C  N R 532 
U   "O2'"  O  N N 533 
U   "C1'"  C  N R 534 
U   N1     N  N N 535 
U   C2     C  N N 536 
U   O2     O  N N 537 
U   N3     N  N N 538 
U   C4     C  N N 539 
U   O4     O  N N 540 
U   C5     C  N N 541 
U   C6     C  N N 542 
U   HOP3   H  N N 543 
U   HOP2   H  N N 544 
U   "H5'"  H  N N 545 
U   "H5''" H  N N 546 
U   "H4'"  H  N N 547 
U   "H3'"  H  N N 548 
U   "HO3'" H  N N 549 
U   "H2'"  H  N N 550 
U   "HO2'" H  N N 551 
U   "H1'"  H  N N 552 
U   H3     H  N N 553 
U   H5     H  N N 554 
U   H6     H  N N 555 
VAL N      N  N N 556 
VAL CA     C  N S 557 
VAL C      C  N N 558 
VAL O      O  N N 559 
VAL CB     C  N N 560 
VAL CG1    C  N N 561 
VAL CG2    C  N N 562 
VAL OXT    O  N N 563 
VAL H      H  N N 564 
VAL H2     H  N N 565 
VAL HA     H  N N 566 
VAL HB     H  N N 567 
VAL HG11   H  N N 568 
VAL HG12   H  N N 569 
VAL HG13   H  N N 570 
VAL HG21   H  N N 571 
VAL HG22   H  N N 572 
VAL HG23   H  N N 573 
VAL HXT    H  N N 574 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ADP PB    O1B    doub N N 40  
ADP PB    O2B    sing N N 41  
ADP PB    O3B    sing N N 42  
ADP PB    O3A    sing N N 43  
ADP O2B   HOB2   sing N N 44  
ADP O3B   HOB3   sing N N 45  
ADP PA    O1A    doub N N 46  
ADP PA    O2A    sing N N 47  
ADP PA    O3A    sing N N 48  
ADP PA    "O5'"  sing N N 49  
ADP O2A   HOA2   sing N N 50  
ADP "O5'" "C5'"  sing N N 51  
ADP "C5'" "C4'"  sing N N 52  
ADP "C5'" "H5'1" sing N N 53  
ADP "C5'" "H5'2" sing N N 54  
ADP "C4'" "O4'"  sing N N 55  
ADP "C4'" "C3'"  sing N N 56  
ADP "C4'" "H4'"  sing N N 57  
ADP "O4'" "C1'"  sing N N 58  
ADP "C3'" "O3'"  sing N N 59  
ADP "C3'" "C2'"  sing N N 60  
ADP "C3'" "H3'"  sing N N 61  
ADP "O3'" "HO3'" sing N N 62  
ADP "C2'" "O2'"  sing N N 63  
ADP "C2'" "C1'"  sing N N 64  
ADP "C2'" "H2'"  sing N N 65  
ADP "O2'" "HO2'" sing N N 66  
ADP "C1'" N9     sing N N 67  
ADP "C1'" "H1'"  sing N N 68  
ADP N9    C8     sing Y N 69  
ADP N9    C4     sing Y N 70  
ADP C8    N7     doub Y N 71  
ADP C8    H8     sing N N 72  
ADP N7    C5     sing Y N 73  
ADP C5    C6     sing Y N 74  
ADP C5    C4     doub Y N 75  
ADP C6    N6     sing N N 76  
ADP C6    N1     doub Y N 77  
ADP N6    HN61   sing N N 78  
ADP N6    HN62   sing N N 79  
ADP N1    C2     sing Y N 80  
ADP C2    N3     doub Y N 81  
ADP C2    H2     sing N N 82  
ADP N3    C4     sing Y N 83  
ALA N     CA     sing N N 84  
ALA N     H      sing N N 85  
ALA N     H2     sing N N 86  
ALA CA    C      sing N N 87  
ALA CA    CB     sing N N 88  
ALA CA    HA     sing N N 89  
ALA C     O      doub N N 90  
ALA C     OXT    sing N N 91  
ALA CB    HB1    sing N N 92  
ALA CB    HB2    sing N N 93  
ALA CB    HB3    sing N N 94  
ALA OXT   HXT    sing N N 95  
ARG N     CA     sing N N 96  
ARG N     H      sing N N 97  
ARG N     H2     sing N N 98  
ARG CA    C      sing N N 99  
ARG CA    CB     sing N N 100 
ARG CA    HA     sing N N 101 
ARG C     O      doub N N 102 
ARG C     OXT    sing N N 103 
ARG CB    CG     sing N N 104 
ARG CB    HB2    sing N N 105 
ARG CB    HB3    sing N N 106 
ARG CG    CD     sing N N 107 
ARG CG    HG2    sing N N 108 
ARG CG    HG3    sing N N 109 
ARG CD    NE     sing N N 110 
ARG CD    HD2    sing N N 111 
ARG CD    HD3    sing N N 112 
ARG NE    CZ     sing N N 113 
ARG NE    HE     sing N N 114 
ARG CZ    NH1    sing N N 115 
ARG CZ    NH2    doub N N 116 
ARG NH1   HH11   sing N N 117 
ARG NH1   HH12   sing N N 118 
ARG NH2   HH21   sing N N 119 
ARG NH2   HH22   sing N N 120 
ARG OXT   HXT    sing N N 121 
ASN N     CA     sing N N 122 
ASN N     H      sing N N 123 
ASN N     H2     sing N N 124 
ASN CA    C      sing N N 125 
ASN CA    CB     sing N N 126 
ASN CA    HA     sing N N 127 
ASN C     O      doub N N 128 
ASN C     OXT    sing N N 129 
ASN CB    CG     sing N N 130 
ASN CB    HB2    sing N N 131 
ASN CB    HB3    sing N N 132 
ASN CG    OD1    doub N N 133 
ASN CG    ND2    sing N N 134 
ASN ND2   HD21   sing N N 135 
ASN ND2   HD22   sing N N 136 
ASN OXT   HXT    sing N N 137 
ASP N     CA     sing N N 138 
ASP N     H      sing N N 139 
ASP N     H2     sing N N 140 
ASP CA    C      sing N N 141 
ASP CA    CB     sing N N 142 
ASP CA    HA     sing N N 143 
ASP C     O      doub N N 144 
ASP C     OXT    sing N N 145 
ASP CB    CG     sing N N 146 
ASP CB    HB2    sing N N 147 
ASP CB    HB3    sing N N 148 
ASP CG    OD1    doub N N 149 
ASP CG    OD2    sing N N 150 
ASP OD2   HD2    sing N N 151 
ASP OXT   HXT    sing N N 152 
C   OP3   P      sing N N 153 
C   OP3   HOP3   sing N N 154 
C   P     OP1    doub N N 155 
C   P     OP2    sing N N 156 
C   P     "O5'"  sing N N 157 
C   OP2   HOP2   sing N N 158 
C   "O5'" "C5'"  sing N N 159 
C   "C5'" "C4'"  sing N N 160 
C   "C5'" "H5'"  sing N N 161 
C   "C5'" "H5''" sing N N 162 
C   "C4'" "O4'"  sing N N 163 
C   "C4'" "C3'"  sing N N 164 
C   "C4'" "H4'"  sing N N 165 
C   "O4'" "C1'"  sing N N 166 
C   "C3'" "O3'"  sing N N 167 
C   "C3'" "C2'"  sing N N 168 
C   "C3'" "H3'"  sing N N 169 
C   "O3'" "HO3'" sing N N 170 
C   "C2'" "O2'"  sing N N 171 
C   "C2'" "C1'"  sing N N 172 
C   "C2'" "H2'"  sing N N 173 
C   "O2'" "HO2'" sing N N 174 
C   "C1'" N1     sing N N 175 
C   "C1'" "H1'"  sing N N 176 
C   N1    C2     sing N N 177 
C   N1    C6     sing N N 178 
C   C2    O2     doub N N 179 
C   C2    N3     sing N N 180 
C   N3    C4     doub N N 181 
C   C4    N4     sing N N 182 
C   C4    C5     sing N N 183 
C   N4    H41    sing N N 184 
C   N4    H42    sing N N 185 
C   C5    C6     doub N N 186 
C   C5    H5     sing N N 187 
C   C6    H6     sing N N 188 
CYS N     CA     sing N N 189 
CYS N     H      sing N N 190 
CYS N     H2     sing N N 191 
CYS CA    C      sing N N 192 
CYS CA    CB     sing N N 193 
CYS CA    HA     sing N N 194 
CYS C     O      doub N N 195 
CYS C     OXT    sing N N 196 
CYS CB    SG     sing N N 197 
CYS CB    HB2    sing N N 198 
CYS CB    HB3    sing N N 199 
CYS SG    HG     sing N N 200 
CYS OXT   HXT    sing N N 201 
G   OP3   P      sing N N 202 
G   OP3   HOP3   sing N N 203 
G   P     OP1    doub N N 204 
G   P     OP2    sing N N 205 
G   P     "O5'"  sing N N 206 
G   OP2   HOP2   sing N N 207 
G   "O5'" "C5'"  sing N N 208 
G   "C5'" "C4'"  sing N N 209 
G   "C5'" "H5'"  sing N N 210 
G   "C5'" "H5''" sing N N 211 
G   "C4'" "O4'"  sing N N 212 
G   "C4'" "C3'"  sing N N 213 
G   "C4'" "H4'"  sing N N 214 
G   "O4'" "C1'"  sing N N 215 
G   "C3'" "O3'"  sing N N 216 
G   "C3'" "C2'"  sing N N 217 
G   "C3'" "H3'"  sing N N 218 
G   "O3'" "HO3'" sing N N 219 
G   "C2'" "O2'"  sing N N 220 
G   "C2'" "C1'"  sing N N 221 
G   "C2'" "H2'"  sing N N 222 
G   "O2'" "HO2'" sing N N 223 
G   "C1'" N9     sing N N 224 
G   "C1'" "H1'"  sing N N 225 
G   N9    C8     sing Y N 226 
G   N9    C4     sing Y N 227 
G   C8    N7     doub Y N 228 
G   C8    H8     sing N N 229 
G   N7    C5     sing Y N 230 
G   C5    C6     sing N N 231 
G   C5    C4     doub Y N 232 
G   C6    O6     doub N N 233 
G   C6    N1     sing N N 234 
G   N1    C2     sing N N 235 
G   N1    H1     sing N N 236 
G   C2    N2     sing N N 237 
G   C2    N3     doub N N 238 
G   N2    H21    sing N N 239 
G   N2    H22    sing N N 240 
G   N3    C4     sing N N 241 
GLN N     CA     sing N N 242 
GLN N     H      sing N N 243 
GLN N     H2     sing N N 244 
GLN CA    C      sing N N 245 
GLN CA    CB     sing N N 246 
GLN CA    HA     sing N N 247 
GLN C     O      doub N N 248 
GLN C     OXT    sing N N 249 
GLN CB    CG     sing N N 250 
GLN CB    HB2    sing N N 251 
GLN CB    HB3    sing N N 252 
GLN CG    CD     sing N N 253 
GLN CG    HG2    sing N N 254 
GLN CG    HG3    sing N N 255 
GLN CD    OE1    doub N N 256 
GLN CD    NE2    sing N N 257 
GLN NE2   HE21   sing N N 258 
GLN NE2   HE22   sing N N 259 
GLN OXT   HXT    sing N N 260 
GLU N     CA     sing N N 261 
GLU N     H      sing N N 262 
GLU N     H2     sing N N 263 
GLU CA    C      sing N N 264 
GLU CA    CB     sing N N 265 
GLU CA    HA     sing N N 266 
GLU C     O      doub N N 267 
GLU C     OXT    sing N N 268 
GLU CB    CG     sing N N 269 
GLU CB    HB2    sing N N 270 
GLU CB    HB3    sing N N 271 
GLU CG    CD     sing N N 272 
GLU CG    HG2    sing N N 273 
GLU CG    HG3    sing N N 274 
GLU CD    OE1    doub N N 275 
GLU CD    OE2    sing N N 276 
GLU OE2   HE2    sing N N 277 
GLU OXT   HXT    sing N N 278 
GLY N     CA     sing N N 279 
GLY N     H      sing N N 280 
GLY N     H2     sing N N 281 
GLY CA    C      sing N N 282 
GLY CA    HA2    sing N N 283 
GLY CA    HA3    sing N N 284 
GLY C     O      doub N N 285 
GLY C     OXT    sing N N 286 
GLY OXT   HXT    sing N N 287 
HIS N     CA     sing N N 288 
HIS N     H      sing N N 289 
HIS N     H2     sing N N 290 
HIS CA    C      sing N N 291 
HIS CA    CB     sing N N 292 
HIS CA    HA     sing N N 293 
HIS C     O      doub N N 294 
HIS C     OXT    sing N N 295 
HIS CB    CG     sing N N 296 
HIS CB    HB2    sing N N 297 
HIS CB    HB3    sing N N 298 
HIS CG    ND1    sing Y N 299 
HIS CG    CD2    doub Y N 300 
HIS ND1   CE1    doub Y N 301 
HIS ND1   HD1    sing N N 302 
HIS CD2   NE2    sing Y N 303 
HIS CD2   HD2    sing N N 304 
HIS CE1   NE2    sing Y N 305 
HIS CE1   HE1    sing N N 306 
HIS NE2   HE2    sing N N 307 
HIS OXT   HXT    sing N N 308 
ILE N     CA     sing N N 309 
ILE N     H      sing N N 310 
ILE N     H2     sing N N 311 
ILE CA    C      sing N N 312 
ILE CA    CB     sing N N 313 
ILE CA    HA     sing N N 314 
ILE C     O      doub N N 315 
ILE C     OXT    sing N N 316 
ILE CB    CG1    sing N N 317 
ILE CB    CG2    sing N N 318 
ILE CB    HB     sing N N 319 
ILE CG1   CD1    sing N N 320 
ILE CG1   HG12   sing N N 321 
ILE CG1   HG13   sing N N 322 
ILE CG2   HG21   sing N N 323 
ILE CG2   HG22   sing N N 324 
ILE CG2   HG23   sing N N 325 
ILE CD1   HD11   sing N N 326 
ILE CD1   HD12   sing N N 327 
ILE CD1   HD13   sing N N 328 
ILE OXT   HXT    sing N N 329 
LEU N     CA     sing N N 330 
LEU N     H      sing N N 331 
LEU N     H2     sing N N 332 
LEU CA    C      sing N N 333 
LEU CA    CB     sing N N 334 
LEU CA    HA     sing N N 335 
LEU C     O      doub N N 336 
LEU C     OXT    sing N N 337 
LEU CB    CG     sing N N 338 
LEU CB    HB2    sing N N 339 
LEU CB    HB3    sing N N 340 
LEU CG    CD1    sing N N 341 
LEU CG    CD2    sing N N 342 
LEU CG    HG     sing N N 343 
LEU CD1   HD11   sing N N 344 
LEU CD1   HD12   sing N N 345 
LEU CD1   HD13   sing N N 346 
LEU CD2   HD21   sing N N 347 
LEU CD2   HD22   sing N N 348 
LEU CD2   HD23   sing N N 349 
LEU OXT   HXT    sing N N 350 
LYS N     CA     sing N N 351 
LYS N     H      sing N N 352 
LYS N     H2     sing N N 353 
LYS CA    C      sing N N 354 
LYS CA    CB     sing N N 355 
LYS CA    HA     sing N N 356 
LYS C     O      doub N N 357 
LYS C     OXT    sing N N 358 
LYS CB    CG     sing N N 359 
LYS CB    HB2    sing N N 360 
LYS CB    HB3    sing N N 361 
LYS CG    CD     sing N N 362 
LYS CG    HG2    sing N N 363 
LYS CG    HG3    sing N N 364 
LYS CD    CE     sing N N 365 
LYS CD    HD2    sing N N 366 
LYS CD    HD3    sing N N 367 
LYS CE    NZ     sing N N 368 
LYS CE    HE2    sing N N 369 
LYS CE    HE3    sing N N 370 
LYS NZ    HZ1    sing N N 371 
LYS NZ    HZ2    sing N N 372 
LYS NZ    HZ3    sing N N 373 
LYS OXT   HXT    sing N N 374 
MET N     CA     sing N N 375 
MET N     H      sing N N 376 
MET N     H2     sing N N 377 
MET CA    C      sing N N 378 
MET CA    CB     sing N N 379 
MET CA    HA     sing N N 380 
MET C     O      doub N N 381 
MET C     OXT    sing N N 382 
MET CB    CG     sing N N 383 
MET CB    HB2    sing N N 384 
MET CB    HB3    sing N N 385 
MET CG    SD     sing N N 386 
MET CG    HG2    sing N N 387 
MET CG    HG3    sing N N 388 
MET SD    CE     sing N N 389 
MET CE    HE1    sing N N 390 
MET CE    HE2    sing N N 391 
MET CE    HE3    sing N N 392 
MET OXT   HXT    sing N N 393 
PHE N     CA     sing N N 394 
PHE N     H      sing N N 395 
PHE N     H2     sing N N 396 
PHE CA    C      sing N N 397 
PHE CA    CB     sing N N 398 
PHE CA    HA     sing N N 399 
PHE C     O      doub N N 400 
PHE C     OXT    sing N N 401 
PHE CB    CG     sing N N 402 
PHE CB    HB2    sing N N 403 
PHE CB    HB3    sing N N 404 
PHE CG    CD1    doub Y N 405 
PHE CG    CD2    sing Y N 406 
PHE CD1   CE1    sing Y N 407 
PHE CD1   HD1    sing N N 408 
PHE CD2   CE2    doub Y N 409 
PHE CD2   HD2    sing N N 410 
PHE CE1   CZ     doub Y N 411 
PHE CE1   HE1    sing N N 412 
PHE CE2   CZ     sing Y N 413 
PHE CE2   HE2    sing N N 414 
PHE CZ    HZ     sing N N 415 
PHE OXT   HXT    sing N N 416 
PRO N     CA     sing N N 417 
PRO N     CD     sing N N 418 
PRO N     H      sing N N 419 
PRO CA    C      sing N N 420 
PRO CA    CB     sing N N 421 
PRO CA    HA     sing N N 422 
PRO C     O      doub N N 423 
PRO C     OXT    sing N N 424 
PRO CB    CG     sing N N 425 
PRO CB    HB2    sing N N 426 
PRO CB    HB3    sing N N 427 
PRO CG    CD     sing N N 428 
PRO CG    HG2    sing N N 429 
PRO CG    HG3    sing N N 430 
PRO CD    HD2    sing N N 431 
PRO CD    HD3    sing N N 432 
PRO OXT   HXT    sing N N 433 
SER N     CA     sing N N 434 
SER N     H      sing N N 435 
SER N     H2     sing N N 436 
SER CA    C      sing N N 437 
SER CA    CB     sing N N 438 
SER CA    HA     sing N N 439 
SER C     O      doub N N 440 
SER C     OXT    sing N N 441 
SER CB    OG     sing N N 442 
SER CB    HB2    sing N N 443 
SER CB    HB3    sing N N 444 
SER OG    HG     sing N N 445 
SER OXT   HXT    sing N N 446 
THR N     CA     sing N N 447 
THR N     H      sing N N 448 
THR N     H2     sing N N 449 
THR CA    C      sing N N 450 
THR CA    CB     sing N N 451 
THR CA    HA     sing N N 452 
THR C     O      doub N N 453 
THR C     OXT    sing N N 454 
THR CB    OG1    sing N N 455 
THR CB    CG2    sing N N 456 
THR CB    HB     sing N N 457 
THR OG1   HG1    sing N N 458 
THR CG2   HG21   sing N N 459 
THR CG2   HG22   sing N N 460 
THR CG2   HG23   sing N N 461 
THR OXT   HXT    sing N N 462 
TRP N     CA     sing N N 463 
TRP N     H      sing N N 464 
TRP N     H2     sing N N 465 
TRP CA    C      sing N N 466 
TRP CA    CB     sing N N 467 
TRP CA    HA     sing N N 468 
TRP C     O      doub N N 469 
TRP C     OXT    sing N N 470 
TRP CB    CG     sing N N 471 
TRP CB    HB2    sing N N 472 
TRP CB    HB3    sing N N 473 
TRP CG    CD1    doub Y N 474 
TRP CG    CD2    sing Y N 475 
TRP CD1   NE1    sing Y N 476 
TRP CD1   HD1    sing N N 477 
TRP CD2   CE2    doub Y N 478 
TRP CD2   CE3    sing Y N 479 
TRP NE1   CE2    sing Y N 480 
TRP NE1   HE1    sing N N 481 
TRP CE2   CZ2    sing Y N 482 
TRP CE3   CZ3    doub Y N 483 
TRP CE3   HE3    sing N N 484 
TRP CZ2   CH2    doub Y N 485 
TRP CZ2   HZ2    sing N N 486 
TRP CZ3   CH2    sing Y N 487 
TRP CZ3   HZ3    sing N N 488 
TRP CH2   HH2    sing N N 489 
TRP OXT   HXT    sing N N 490 
TYR N     CA     sing N N 491 
TYR N     H      sing N N 492 
TYR N     H2     sing N N 493 
TYR CA    C      sing N N 494 
TYR CA    CB     sing N N 495 
TYR CA    HA     sing N N 496 
TYR C     O      doub N N 497 
TYR C     OXT    sing N N 498 
TYR CB    CG     sing N N 499 
TYR CB    HB2    sing N N 500 
TYR CB    HB3    sing N N 501 
TYR CG    CD1    doub Y N 502 
TYR CG    CD2    sing Y N 503 
TYR CD1   CE1    sing Y N 504 
TYR CD1   HD1    sing N N 505 
TYR CD2   CE2    doub Y N 506 
TYR CD2   HD2    sing N N 507 
TYR CE1   CZ     doub Y N 508 
TYR CE1   HE1    sing N N 509 
TYR CE2   CZ     sing Y N 510 
TYR CE2   HE2    sing N N 511 
TYR CZ    OH     sing N N 512 
TYR OH    HH     sing N N 513 
TYR OXT   HXT    sing N N 514 
U   OP3   P      sing N N 515 
U   OP3   HOP3   sing N N 516 
U   P     OP1    doub N N 517 
U   P     OP2    sing N N 518 
U   P     "O5'"  sing N N 519 
U   OP2   HOP2   sing N N 520 
U   "O5'" "C5'"  sing N N 521 
U   "C5'" "C4'"  sing N N 522 
U   "C5'" "H5'"  sing N N 523 
U   "C5'" "H5''" sing N N 524 
U   "C4'" "O4'"  sing N N 525 
U   "C4'" "C3'"  sing N N 526 
U   "C4'" "H4'"  sing N N 527 
U   "O4'" "C1'"  sing N N 528 
U   "C3'" "O3'"  sing N N 529 
U   "C3'" "C2'"  sing N N 530 
U   "C3'" "H3'"  sing N N 531 
U   "O3'" "HO3'" sing N N 532 
U   "C2'" "O2'"  sing N N 533 
U   "C2'" "C1'"  sing N N 534 
U   "C2'" "H2'"  sing N N 535 
U   "O2'" "HO2'" sing N N 536 
U   "C1'" N1     sing N N 537 
U   "C1'" "H1'"  sing N N 538 
U   N1    C2     sing N N 539 
U   N1    C6     sing N N 540 
U   C2    O2     doub N N 541 
U   C2    N3     sing N N 542 
U   N3    C4     sing N N 543 
U   N3    H3     sing N N 544 
U   C4    O4     doub N N 545 
U   C4    C5     sing N N 546 
U   C5    C6     doub N N 547 
U   C5    H5     sing N N 548 
U   C6    H6     sing N N 549 
VAL N     CA     sing N N 550 
VAL N     H      sing N N 551 
VAL N     H2     sing N N 552 
VAL CA    C      sing N N 553 
VAL CA    CB     sing N N 554 
VAL CA    HA     sing N N 555 
VAL C     O      doub N N 556 
VAL C     OXT    sing N N 557 
VAL CB    CG1    sing N N 558 
VAL CB    CG2    sing N N 559 
VAL CB    HB     sing N N 560 
VAL CG1   HG11   sing N N 561 
VAL CG1   HG12   sing N N 562 
VAL CG1   HG13   sing N N 563 
VAL CG2   HG21   sing N N 564 
VAL CG2   HG22   sing N N 565 
VAL CG2   HG23   sing N N 566 
VAL OXT   HXT    sing N N 567 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2025-01-17 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9MW8 
_em_admin.last_update        2025-06-04 
_em_admin.map_release_date   2025-03-12 
_em_admin.title              'Cryo-EM structure of ancestral Dicer helicase bound to 27-bp dsRNA in post-hydrolysis closed state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.093 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          32630 
_em_entity_assembly_naturalsource.organism             'synthetic construct' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         40 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? cryoSPARC ?           
'IMAGE ACQUISITION'        ? 2  ? ? 1 EPU       ?           
MASKING                    ? 3  ? ? ? ?         ?           
'CTF CORRECTION'           ? 4  1 ? ? cryoSPARC ?           
'LAYERLINE INDEXING'       ? 5  ? ? ? ?         ?           
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?         ?           
'MODEL FITTING'            ? 7  ? 1 ? Coot      ?           
OTHER                      ? 8  ? ? ? ?         ?           
'MODEL REFINEMENT'         ? 9  ? 1 ? PHENIX    1.21.1_5286 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? cryoSPARC ?           
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? cryoSPARC ?           
CLASSIFICATION             ? 12 1 ? ? cryoSPARC ?           
RECONSTRUCTION             ? 13 1 ? ? cryoSPARC ?           
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
9MW8 'double helix'        
9MW8 'a-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B A 1  1_555 C U 27 1_555 0.034  -0.092 -0.354 -3.087 -5.124 1.338  1  B_A1:U27_C  B 1  ? C 27 ? 20 1 
1 B U 2  1_555 C A 26 1_555 -0.077 -0.130 -0.329 -2.183 -4.106 1.016  2  B_U2:A26_C  B 2  ? C 26 ? 20 1 
1 B A 3  1_555 C U 25 1_555 0.047  -0.121 -0.368 -3.494 1.027  -0.987 3  B_A3:U25_C  B 3  ? C 25 ? 20 1 
1 B C 4  1_555 C G 24 1_555 0.190  -0.164 -0.280 1.506  -0.594 -1.031 4  B_C4:G24_C  B 4  ? C 24 ? 19 1 
1 B G 5  1_555 C C 23 1_555 -0.194 -0.152 0.266  -0.485 7.837  0.833  5  B_G5:C23_C  B 5  ? C 23 ? 19 1 
1 B U 6  1_555 C A 22 1_555 -0.036 -0.111 0.246  1.988  8.237  1.086  6  B_U6:A22_C  B 6  ? C 22 ? 20 1 
1 B C 7  1_555 C G 21 1_555 0.208  -0.144 0.013  3.879  9.213  0.820  7  B_C7:G21_C  B 7  ? C 21 ? 19 1 
1 B C 8  1_555 C G 20 1_555 0.183  -0.155 -0.424 -2.257 1.066  0.096  8  B_C8:G20_C  B 8  ? C 20 ? 19 1 
1 B U 9  1_555 C A 19 1_555 -0.040 -0.107 -0.202 -1.168 -4.727 2.089  9  B_U9:A19_C  B 9  ? C 19 ? 20 1 
1 B G 10 1_555 C C 18 1_555 -0.194 -0.137 0.126  -2.340 4.392  0.926  10 B_G10:C18_C B 10 ? C 18 ? 19 1 
1 B A 11 1_555 C U 17 1_555 0.063  -0.093 0.205  1.104  3.063  1.427  11 B_A11:U17_C B 11 ? C 17 ? 20 1 
1 B U 12 1_555 C A 16 1_555 -0.045 -0.104 0.235  1.599  -1.041 1.650  12 B_U12:A16_C B 12 ? C 16 ? 20 1 
1 B A 13 1_555 C U 15 1_555 0.050  -0.087 0.195  1.844  4.744  0.074  13 B_A13:U15_C B 13 ? C 15 ? 20 1 
1 B G 14 1_555 C C 14 1_555 -0.179 -0.152 0.027  0.515  3.052  -0.648 14 B_G14:C14_C B 14 ? C 14 ? 19 1 
1 B U 15 1_555 C A 13 1_555 -0.032 -0.086 -0.092 1.668  2.567  0.380  15 B_U15:A13_C B 15 ? C 13 ? 20 1 
1 B U 16 1_555 C A 12 1_555 -0.058 -0.077 -0.154 1.666  -2.203 1.514  16 B_U16:A12_C B 16 ? C 12 ? 20 1 
1 B A 17 1_555 C U 11 1_555 0.031  -0.099 -0.278 -4.219 -1.286 0.831  17 B_A17:U11_C B 17 ? C 11 ? 20 1 
1 B G 18 1_555 C C 10 1_555 -0.189 -0.144 -0.273 -2.558 -0.728 0.170  18 B_G18:C10_C B 18 ? C 10 ? 19 1 
1 B U 19 1_555 C A 9  1_555 -0.020 -0.111 -0.223 -0.274 -2.670 2.043  19 B_U19:A9_C  B 19 ? C 9  ? 20 1 
1 B A 20 1_555 C U 8  1_555 0.086  -0.076 0.212  -1.250 3.631  1.462  20 B_A20:U8_C  B 20 ? C 8  ? 20 1 
1 B U 21 1_555 C A 7  1_555 -0.042 -0.075 0.195  2.426  2.721  0.408  21 B_U21:A7_C  B 21 ? C 7  ? 20 1 
1 B C 22 1_555 C G 6  1_555 0.194  -0.139 0.203  2.536  0.431  0.388  22 B_C22:G6_C  B 22 ? C 6  ? 19 1 
1 B C 23 1_555 C G 5  1_555 0.186  -0.168 0.367  0.950  -2.739 -0.564 23 B_C23:G5_C  B 23 ? C 5  ? 19 1 
1 B A 24 1_555 C U 4  1_555 0.069  -0.066 0.134  4.155  0.083  -0.218 24 B_A24:U4_C  B 24 ? C 4  ? 20 1 
1 B U 25 1_555 C A 3  1_555 -0.133 -0.020 -0.382 8.066  -2.084 -3.813 25 B_U25:A3_C  B 25 ? C 3  ? 20 1 
1 B C 26 1_555 C G 2  1_555 0.246  -0.123 -0.437 10.172 -9.324 1.685  26 B_C26:G2_C  B 26 ? C 2  ? 19 1 
1 B G 27 1_555 C C 1  1_555 -0.100 -0.354 -1.083 -4.350 3.564  -4.495 27 B_G27:C1_C  B 27 ? C 1  ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B A 1  1_555 C U 27 1_555 B U 2  1_555 C A 26 1_555 -0.624 -1.479 3.411 -2.323 -0.511  33.850 -2.448 0.677  3.466 -0.877  3.984 
33.932 1  BB_A1U2:A26U27_CC   B 1  ? C 27 ? B 2  ? C 26 ? 
1 B U 2  1_555 C A 26 1_555 B A 3  1_555 C U 25 1_555 -0.446 -1.128 3.509 -1.571 3.452   34.062 -2.489 0.496  3.398 5.871   2.671 
34.266 2  BB_U2A3:U25A26_CC   B 2  ? C 26 ? B 3  ? C 25 ? 
1 B A 3  1_555 C U 25 1_555 B C 4  1_555 C G 24 1_555 0.087  -1.400 3.185 -0.201 2.750   32.914 -2.908 -0.185 3.061 4.842   0.354 
33.026 3  BB_A3C4:G24U25_CC   B 3  ? C 25 ? B 4  ? C 24 ? 
1 B C 4  1_555 C G 24 1_555 B G 5  1_555 C C 23 1_555 0.385  -1.522 3.033 -3.496 9.753   31.977 -4.003 -1.157 2.423 17.150  6.148 
33.572 4  BB_C4G5:C23G24_CC   B 4  ? C 24 ? B 5  ? C 23 ? 
1 B G 5  1_555 C C 23 1_555 B U 6  1_555 C A 22 1_555 0.203  -1.889 3.186 0.213  4.320   34.650 -3.763 -0.308 2.938 7.219   -0.356 
34.911 5  BB_G5U6:A22C23_CC   B 5  ? C 23 ? B 6  ? C 22 ? 
1 B U 6  1_555 C A 22 1_555 B C 7  1_555 C G 21 1_555 0.252  -1.823 3.071 2.683  5.678   34.042 -3.851 -0.053 2.752 9.597   -4.536 
34.600 6  BB_U6C7:G21A22_CC   B 6  ? C 22 ? B 7  ? C 21 ? 
1 B C 7  1_555 C G 21 1_555 B C 8  1_555 C G 20 1_555 0.146  -1.841 3.178 5.996  11.449  32.840 -4.552 0.549  2.411 19.344  
-10.130 35.226 7  BB_C7C8:G20G21_CC   B 7  ? C 21 ? B 8  ? C 20 ? 
1 B C 8  1_555 C G 20 1_555 B U 9  1_555 C A 19 1_555 -0.037 -1.545 3.060 -0.640 9.289   30.383 -4.306 -0.035 2.491 17.223  1.186 
31.746 8  BB_C8U9:A19G20_CC   B 8  ? C 20 ? B 9  ? C 19 ? 
1 B U 9  1_555 C A 19 1_555 B G 10 1_555 C C 18 1_555 -0.016 -1.452 3.049 -2.706 8.303   31.350 -3.869 -0.387 2.583 15.004  4.889 
32.514 9  BB_U9G10:C18A19_CC  B 9  ? C 19 ? B 10 ? C 18 ? 
1 B G 10 1_555 C C 18 1_555 B A 11 1_555 C U 17 1_555 0.066  -1.685 3.047 -0.665 4.713   32.737 -3.674 -0.216 2.782 8.306   1.172 
33.071 10 BB_G10A11:U17C18_CC B 10 ? C 18 ? B 11 ? C 17 ? 
1 B A 11 1_555 C U 17 1_555 B U 12 1_555 C A 16 1_555 0.059  -1.833 3.201 0.893  3.481   32.414 -3.839 0.042  2.993 6.211   -1.593 
32.607 11 BB_A11U12:A16U17_CC B 11 ? C 17 ? B 12 ? C 16 ? 
1 B U 12 1_555 C A 16 1_555 B A 13 1_555 C U 15 1_555 -0.214 -1.505 2.802 0.710  12.153  35.279 -3.619 0.408  2.179 19.355  -1.131 
37.257 12 BB_U12A13:U15A16_CC B 12 ? C 16 ? B 13 ? C 15 ? 
1 B A 13 1_555 C U 15 1_555 B G 14 1_555 C C 14 1_555 -0.034 -1.768 3.093 0.868  6.196   31.793 -4.148 0.197  2.707 11.176  -1.565 
32.387 13 BB_A13G14:C14U15_CC B 13 ? C 15 ? B 14 ? C 14 ? 
1 B G 14 1_555 C C 14 1_555 B U 15 1_555 C A 13 1_555 0.224  -1.787 3.130 1.505  3.134   33.694 -3.538 -0.158 2.964 5.389   -2.587 
33.868 14 BB_G14U15:A13C14_CC B 14 ? C 14 ? B 15 ? C 13 ? 
1 B U 15 1_555 C A 13 1_555 B U 16 1_555 C A 12 1_555 0.192  -1.722 3.023 2.183  6.532   31.524 -4.116 -0.005 2.629 11.847  -3.959 
32.249 15 BB_U15U16:A12A13_CC B 15 ? C 13 ? B 16 ? C 12 ? 
1 B U 16 1_555 C A 12 1_555 B A 17 1_555 C U 11 1_555 -0.199 -1.517 3.167 -0.335 10.374  32.926 -4.010 0.288  2.586 17.761  0.574 
34.480 16 BB_U16A17:U11A12_CC B 16 ? C 12 ? B 17 ? C 11 ? 
1 B A 17 1_555 C U 11 1_555 B G 18 1_555 C C 10 1_555 0.115  -1.841 3.074 -0.679 3.594   28.806 -4.387 -0.365 2.825 7.188   1.358 
29.033 17 BB_A17G18:C10U11_CC B 17 ? C 11 ? B 18 ? C 10 ? 
1 B G 18 1_555 C C 10 1_555 B U 19 1_555 C A 9  1_555 0.228  -1.896 3.076 0.600  2.694   32.660 -3.785 -0.308 2.918 4.780   -1.064 
32.773 18 BB_G18U19:A9C10_CC  B 18 ? C 10 ? B 19 ? C 9  ? 
1 B U 19 1_555 C A 9  1_555 B A 20 1_555 C U 8  1_555 0.210  -1.529 2.945 -1.542 9.286   31.787 -3.990 -0.586 2.403 16.508  2.741 
33.117 19 BB_U19A20:U8A9_CC   B 19 ? C 9  ? B 20 ? C 8  ? 
1 B A 20 1_555 C U 8  1_555 B U 21 1_555 C A 7  1_555 0.157  -1.707 3.113 0.766  3.034   30.529 -3.779 -0.157 2.936 5.743   -1.450 
30.685 20 BB_A20U21:A7U8_CC   B 20 ? C 8  ? B 21 ? C 7  ? 
1 B U 21 1_555 C A 7  1_555 B C 22 1_555 C G 6  1_555 0.202  -1.701 3.100 0.990  3.079   33.104 -3.448 -0.199 2.939 5.387   -1.732 
33.257 21 BB_U21C22:G6A7_CC   B 21 ? C 7  ? B 22 ? C 6  ? 
1 B C 22 1_555 C G 6  1_555 B C 23 1_555 C G 5  1_555 0.014  -1.689 3.202 0.698  2.376   32.075 -3.456 0.094  3.072 4.292   -1.261 
32.168 22 BB_C22C23:G5G6_CC   B 22 ? C 6  ? B 23 ? C 5  ? 
1 B C 23 1_555 C G 5  1_555 B A 24 1_555 C U 4  1_555 -0.091 -1.656 2.819 2.824  7.199   33.962 -3.657 0.501  2.413 12.129  -4.758 
34.806 23 BB_C23A24:U4G5_CC   B 23 ? C 5  ? B 24 ? C 4  ? 
1 B A 24 1_555 C U 4  1_555 B U 25 1_555 C A 3  1_555 -0.207 -1.630 3.144 4.647  0.781   31.791 -3.078 1.167  3.044 1.416   -8.426 
32.129 24 BB_A24U25:A3U4_CC   B 24 ? C 4  ? B 25 ? C 3  ? 
1 B U 25 1_555 C A 3  1_555 B C 26 1_555 C G 2  1_555 0.329  -1.552 3.274 4.815  0.104   34.452 -2.613 0.189  3.284 0.174   -8.081 
34.777 25 BB_U25C26:G2A3_CC   B 25 ? C 3  ? B 26 ? C 2  ? 
1 B C 26 1_555 C G 2  1_555 B G 27 1_555 C C 1  1_555 1.966  -0.969 4.575 13.931 -13.969 20.238 3.456  1.396  4.737 -31.653 
-31.566 28.191 26 BB_C26G27:C1G2_CC   B 26 ? C 2  ? B 27 ? C 1  ? 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R35 GM141262' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
# 
_atom_sites.entry_id                    9MW8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . GLU A 1 6   ? 118.857 146.278 192.495 1.00 233.80 ? 6   GLU A N     1 
ATOM   2    C  CA    . GLU A 1 6   ? 119.016 145.859 191.107 1.00 233.80 ? 6   GLU A CA    1 
ATOM   3    C  C     . GLU A 1 6   ? 118.406 146.944 190.212 1.00 233.80 ? 6   GLU A C     1 
ATOM   4    O  O     . GLU A 1 6   ? 117.565 147.724 190.661 1.00 233.80 ? 6   GLU A O     1 
ATOM   5    C  CB    . GLU A 1 6   ? 118.406 144.450 190.915 1.00 233.80 ? 6   GLU A CB    1 
ATOM   6    C  CG    . GLU A 1 6   ? 118.056 143.950 189.499 1.00 233.80 ? 6   GLU A CG    1 
ATOM   7    C  CD    . GLU A 1 6   ? 116.876 144.647 188.852 1.00 233.80 ? 6   GLU A CD    1 
ATOM   8    O  OE1   . GLU A 1 6   ? 116.150 145.373 189.558 1.00 233.80 ? 6   GLU A OE1   1 
ATOM   9    O  OE2   . GLU A 1 6   ? 116.674 144.469 187.633 1.00 233.80 ? 6   GLU A OE2   1 
ATOM   10   N  N     . ASP A 1 7   ? 118.846 146.987 188.951 1.00 215.11 ? 7   ASP A N     1 
ATOM   11   C  CA    . ASP A 1 7   ? 118.612 148.154 188.101 1.00 215.11 ? 7   ASP A CA    1 
ATOM   12   C  C     . ASP A 1 7   ? 117.128 148.450 187.897 1.00 215.11 ? 7   ASP A C     1 
ATOM   13   O  O     . ASP A 1 7   ? 116.755 149.618 187.736 1.00 215.11 ? 7   ASP A O     1 
ATOM   14   C  CB    . ASP A 1 7   ? 119.312 147.956 186.755 1.00 215.11 ? 7   ASP A CB    1 
ATOM   15   C  CG    . ASP A 1 7   ? 118.712 148.801 185.651 1.00 215.11 ? 7   ASP A CG    1 
ATOM   16   O  OD1   . ASP A 1 7   ? 119.006 150.013 185.600 1.00 215.11 ? 7   ASP A OD1   1 
ATOM   17   O  OD2   . ASP A 1 7   ? 117.950 148.251 184.830 1.00 215.11 ? 7   ASP A OD2   1 
ATOM   18   N  N     . GLU A 1 8   ? 116.275 147.427 187.908 1.00 230.96 ? 8   GLU A N     1 
ATOM   19   C  CA    . GLU A 1 8   ? 114.845 147.578 187.619 1.00 230.96 ? 8   GLU A CA    1 
ATOM   20   C  C     . GLU A 1 8   ? 114.628 148.199 186.241 1.00 230.96 ? 8   GLU A C     1 
ATOM   21   O  O     . GLU A 1 8   ? 114.094 149.300 186.095 1.00 230.96 ? 8   GLU A O     1 
ATOM   22   C  CB    . GLU A 1 8   ? 114.137 148.395 188.706 1.00 230.96 ? 8   GLU A CB    1 
ATOM   23   C  CG    . GLU A 1 8   ? 113.998 147.709 190.056 1.00 230.96 ? 8   GLU A CG    1 
ATOM   24   C  CD    . GLU A 1 8   ? 113.247 146.391 189.962 1.00 230.96 ? 8   GLU A CD    1 
ATOM   25   O  OE1   . GLU A 1 8   ? 112.229 146.339 189.240 1.00 230.96 ? 8   GLU A OE1   1 
ATOM   26   O  OE2   . GLU A 1 8   ? 113.658 145.417 190.625 1.00 230.96 ? 8   GLU A OE2   1 
ATOM   27   N  N     . PHE A 1 9   ? 115.062 147.466 185.220 1.00 195.07 ? 9   PHE A N     1 
ATOM   28   C  CA    . PHE A 1 9   ? 114.900 147.926 183.852 1.00 195.07 ? 9   PHE A CA    1 
ATOM   29   C  C     . PHE A 1 9   ? 113.424 147.947 183.466 1.00 195.07 ? 9   PHE A C     1 
ATOM   30   O  O     . PHE A 1 9   ? 112.595 147.215 184.014 1.00 195.07 ? 9   PHE A O     1 
ATOM   31   C  CB    . PHE A 1 9   ? 115.683 147.029 182.894 1.00 195.07 ? 9   PHE A CB    1 
ATOM   32   C  CG    . PHE A 1 9   ? 114.834 146.024 182.168 1.00 195.07 ? 9   PHE A CG    1 
ATOM   33   C  CD1   . PHE A 1 9   ? 114.293 146.314 180.924 1.00 195.07 ? 9   PHE A CD1   1 
ATOM   34   C  CD2   . PHE A 1 9   ? 114.571 144.787 182.736 1.00 195.07 ? 9   PHE A CD2   1 
ATOM   35   C  CE1   . PHE A 1 9   ? 113.516 145.390 180.261 1.00 195.07 ? 9   PHE A CE1   1 
ATOM   36   C  CE2   . PHE A 1 9   ? 113.789 143.859 182.076 1.00 195.07 ? 9   PHE A CE2   1 
ATOM   37   C  CZ    . PHE A 1 9   ? 113.260 144.160 180.837 1.00 195.07 ? 9   PHE A CZ    1 
ATOM   38   N  N     . THR A 1 10  ? 113.103 148.801 182.502 1.00 161.52 ? 10  THR A N     1 
ATOM   39   C  CA    . THR A 1 10  ? 111.753 148.891 181.949 1.00 161.52 ? 10  THR A CA    1 
ATOM   40   C  C     . THR A 1 10  ? 111.827 148.635 180.451 1.00 161.52 ? 10  THR A C     1 
ATOM   41   O  O     . THR A 1 10  ? 112.596 149.323 179.747 1.00 161.52 ? 10  THR A O     1 
ATOM   42   C  CB    . THR A 1 10  ? 111.126 150.251 182.240 1.00 161.52 ? 10  THR A CB    1 
ATOM   43   O  OG1   . THR A 1 10  ? 112.115 151.277 182.088 1.00 161.52 ? 10  THR A OG1   1 
ATOM   44   C  CG2   . THR A 1 10  ? 110.582 150.288 183.659 1.00 161.52 ? 10  THR A CG2   1 
ATOM   45   N  N     . PRO A 1 11  ? 111.078 147.669 179.928 1.00 147.15 ? 11  PRO A N     1 
ATOM   46   C  CA    . PRO A 1 11  ? 111.148 147.377 178.493 1.00 147.15 ? 11  PRO A CA    1 
ATOM   47   C  C     . PRO A 1 11  ? 110.676 148.556 177.656 1.00 147.15 ? 11  PRO A C     1 
ATOM   48   O  O     . PRO A 1 11  ? 109.803 149.325 178.061 1.00 147.15 ? 11  PRO A O     1 
ATOM   49   C  CB    . PRO A 1 11  ? 110.218 146.169 178.329 1.00 147.15 ? 11  PRO A CB    1 
ATOM   50   C  CG    . PRO A 1 11  ? 110.113 145.574 179.697 1.00 147.15 ? 11  PRO A CG    1 
ATOM   51   C  CD    . PRO A 1 11  ? 110.196 146.732 180.641 1.00 147.15 ? 11  PRO A CD    1 
ATOM   52   N  N     . ARG A 1 12  ? 111.267 148.690 176.487 1.00 159.71 ? 12  ARG A N     1 
ATOM   53   C  CA    . ARG A 1 12  ? 110.868 149.675 175.499 1.00 159.71 ? 12  ARG A CA    1 
ATOM   54   C  C     . ARG A 1 12  ? 110.170 148.991 174.335 1.00 159.71 ? 12  ARG A C     1 
ATOM   55   O  O     . ARG A 1 12  ? 110.430 147.819 174.046 1.00 159.71 ? 12  ARG A O     1 
ATOM   56   C  CB    . ARG A 1 12  ? 112.092 150.451 175.008 1.00 159.71 ? 12  ARG A CB    1 
ATOM   57   C  CG    . ARG A 1 12  ? 112.954 150.989 176.139 1.00 159.71 ? 12  ARG A CG    1 
ATOM   58   C  CD    . ARG A 1 12  ? 114.324 151.417 175.648 1.00 159.71 ? 12  ARG A CD    1 
ATOM   59   N  NE    . ARG A 1 12  ? 115.184 151.841 176.745 1.00 159.71 ? 12  ARG A NE    1 
ATOM   60   C  CZ    . ARG A 1 12  ? 116.507 151.902 176.679 1.00 159.71 ? 12  ARG A CZ    1 
ATOM   61   N  NH1   . ARG A 1 12  ? 117.159 151.577 175.575 1.00 159.71 ? 12  ARG A NH1   1 
ATOM   62   N  NH2   . ARG A 1 12  ? 117.193 152.295 177.748 1.00 159.71 ? 12  ARG A NH2   1 
ATOM   63   N  N     . PRO A 1 13  ? 109.256 149.691 173.652 1.00 174.52 ? 13  PRO A N     1 
ATOM   64   C  CA    . PRO A 1 13  ? 108.417 149.010 172.647 1.00 174.52 ? 13  PRO A CA    1 
ATOM   65   C  C     . PRO A 1 13  ? 109.198 148.300 171.552 1.00 174.52 ? 13  PRO A C     1 
ATOM   66   O  O     . PRO A 1 13  ? 108.833 147.180 171.164 1.00 174.52 ? 13  PRO A O     1 
ATOM   67   C  CB    . PRO A 1 13  ? 107.563 150.154 172.082 1.00 174.52 ? 13  PRO A CB    1 
ATOM   68   C  CG    . PRO A 1 13  ? 107.523 151.166 173.178 1.00 174.52 ? 13  PRO A CG    1 
ATOM   69   C  CD    . PRO A 1 13  ? 108.869 151.101 173.831 1.00 174.52 ? 13  PRO A CD    1 
ATOM   70   N  N     . TYR A 1 14  ? 110.275 148.907 171.052 1.00 185.72 ? 14  TYR A N     1 
ATOM   71   C  CA    . TYR A 1 14  ? 111.034 148.259 169.989 1.00 185.72 ? 14  TYR A CA    1 
ATOM   72   C  C     . TYR A 1 14  ? 111.761 147.022 170.496 1.00 185.72 ? 14  TYR A C     1 
ATOM   73   O  O     . TYR A 1 14  ? 111.971 146.075 169.732 1.00 185.72 ? 14  TYR A O     1 
ATOM   74   C  CB    . TYR A 1 14  ? 112.019 149.242 169.353 1.00 185.72 ? 14  TYR A CB    1 
ATOM   75   C  CG    . TYR A 1 14  ? 113.052 149.817 170.294 1.00 185.72 ? 14  TYR A CG    1 
ATOM   76   C  CD1   . TYR A 1 14  ? 112.733 150.851 171.163 1.00 185.72 ? 14  TYR A CD1   1 
ATOM   77   C  CD2   . TYR A 1 14  ? 114.352 149.332 170.303 1.00 185.72 ? 14  TYR A CD2   1 
ATOM   78   C  CE1   . TYR A 1 14  ? 113.679 151.382 172.018 1.00 185.72 ? 14  TYR A CE1   1 
ATOM   79   C  CE2   . TYR A 1 14  ? 115.304 149.855 171.154 1.00 185.72 ? 14  TYR A CE2   1 
ATOM   80   C  CZ    . TYR A 1 14  ? 114.963 150.880 172.010 1.00 185.72 ? 14  TYR A CZ    1 
ATOM   81   O  OH    . TYR A 1 14  ? 115.910 151.404 172.859 1.00 185.72 ? 14  TYR A OH    1 
ATOM   82   N  N     . GLN A 1 15  ? 112.132 147.000 171.779 1.00 181.08 ? 15  GLN A N     1 
ATOM   83   C  CA    . GLN A 1 15  ? 112.771 145.814 172.343 1.00 181.08 ? 15  GLN A CA    1 
ATOM   84   C  C     . GLN A 1 15  ? 111.843 144.607 172.274 1.00 181.08 ? 15  GLN A C     1 
ATOM   85   O  O     . GLN A 1 15  ? 112.236 143.531 171.811 1.00 181.08 ? 15  GLN A O     1 
ATOM   86   C  CB    . GLN A 1 15  ? 113.197 146.087 173.785 1.00 181.08 ? 15  GLN A CB    1 
ATOM   87   C  CG    . GLN A 1 15  ? 114.212 147.205 173.929 1.00 181.08 ? 15  GLN A CG    1 
ATOM   88   C  CD    . GLN A 1 15  ? 114.402 147.632 175.369 1.00 181.08 ? 15  GLN A CD    1 
ATOM   89   O  OE1   . GLN A 1 15  ? 113.449 147.678 176.146 1.00 181.08 ? 15  GLN A OE1   1 
ATOM   90   N  NE2   . GLN A 1 15  ? 115.639 147.948 175.734 1.00 181.08 ? 15  GLN A NE2   1 
ATOM   91   N  N     . VAL A 1 16  ? 110.595 144.771 172.720 1.00 168.07 ? 16  VAL A N     1 
ATOM   92   C  CA    . VAL A 1 16  ? 109.636 143.672 172.669 1.00 168.07 ? 16  VAL A CA    1 
ATOM   93   C  C     . VAL A 1 16  ? 109.279 143.337 171.225 1.00 168.07 ? 16  VAL A C     1 
ATOM   94   O  O     . VAL A 1 16  ? 109.083 142.165 170.871 1.00 168.07 ? 16  VAL A O     1 
ATOM   95   C  CB    . VAL A 1 16  ? 108.388 144.022 173.499 1.00 168.07 ? 16  VAL A CB    1 
ATOM   96   C  CG1   . VAL A 1 16  ? 107.508 142.798 173.678 1.00 168.07 ? 16  VAL A CG1   1 
ATOM   97   C  CG2   . VAL A 1 16  ? 108.795 144.594 174.848 1.00 168.07 ? 16  VAL A CG2   1 
ATOM   98   N  N     . GLU A 1 17  ? 109.184 144.361 170.371 1.00 186.84 ? 17  GLU A N     1 
ATOM   99   C  CA    . GLU A 1 17  ? 108.897 144.124 168.960 1.00 186.84 ? 17  GLU A CA    1 
ATOM   100  C  C     . GLU A 1 17  ? 109.968 143.251 168.319 1.00 186.84 ? 17  GLU A C     1 
ATOM   101  O  O     . GLU A 1 17  ? 109.661 142.366 167.512 1.00 186.84 ? 17  GLU A O     1 
ATOM   102  C  CB    . GLU A 1 17  ? 108.775 145.456 168.221 1.00 186.84 ? 17  GLU A CB    1 
ATOM   103  C  CG    . GLU A 1 17  ? 108.424 145.316 166.752 1.00 186.84 ? 17  GLU A CG    1 
ATOM   104  C  CD    . GLU A 1 17  ? 106.953 145.028 166.535 1.00 186.84 ? 17  GLU A CD    1 
ATOM   105  O  OE1   . GLU A 1 17  ? 106.115 145.823 167.006 1.00 186.84 ? 17  GLU A OE1   1 
ATOM   106  O  OE2   . GLU A 1 17  ? 106.636 144.004 165.893 1.00 186.84 ? 17  GLU A OE2   1 
ATOM   107  N  N     . LEU A 1 18  ? 111.236 143.491 168.659 1.00 182.33 ? 18  LEU A N     1 
ATOM   108  C  CA    . LEU A 1 18  ? 112.310 142.656 168.135 1.00 182.33 ? 18  LEU A CA    1 
ATOM   109  C  C     . LEU A 1 18  ? 112.321 141.284 168.796 1.00 182.33 ? 18  LEU A C     1 
ATOM   110  O  O     . LEU A 1 18  ? 112.644 140.281 168.148 1.00 182.33 ? 18  LEU A O     1 
ATOM   111  C  CB    . LEU A 1 18  ? 113.655 143.357 168.322 1.00 182.33 ? 18  LEU A CB    1 
ATOM   112  C  CG    . LEU A 1 18  ? 113.876 144.598 167.456 1.00 182.33 ? 18  LEU A CG    1 
ATOM   113  C  CD1   . LEU A 1 18  ? 115.349 144.962 167.400 1.00 182.33 ? 18  LEU A CD1   1 
ATOM   114  C  CD2   . LEU A 1 18  ? 113.329 144.369 166.059 1.00 182.33 ? 18  LEU A CD2   1 
ATOM   115  N  N     . LEU A 1 19  ? 111.986 141.220 170.088 1.00 166.97 ? 19  LEU A N     1 
ATOM   116  C  CA    . LEU A 1 19  ? 112.006 139.944 170.795 1.00 166.97 ? 19  LEU A CA    1 
ATOM   117  C  C     . LEU A 1 19  ? 111.001 138.963 170.211 1.00 166.97 ? 19  LEU A C     1 
ATOM   118  O  O     . LEU A 1 19  ? 111.311 137.776 170.041 1.00 166.97 ? 19  LEU A O     1 
ATOM   119  C  CB    . LEU A 1 19  ? 111.726 140.158 172.281 1.00 166.97 ? 19  LEU A CB    1 
ATOM   120  C  CG    . LEU A 1 19  ? 111.360 138.865 173.013 1.00 166.97 ? 19  LEU A CG    1 
ATOM   121  C  CD1   . LEU A 1 19  ? 112.604 138.064 173.350 1.00 166.97 ? 19  LEU A CD1   1 
ATOM   122  C  CD2   . LEU A 1 19  ? 110.542 139.158 174.259 1.00 166.97 ? 19  LEU A CD2   1 
ATOM   123  N  N     . GLU A 1 20  ? 109.786 139.429 169.917 1.00 176.89 ? 20  GLU A N     1 
ATOM   124  C  CA    . GLU A 1 20  ? 108.784 138.516 169.373 1.00 176.89 ? 20  GLU A CA    1 
ATOM   125  C  C     . GLU A 1 20  ? 109.221 137.967 168.018 1.00 176.89 ? 20  GLU A C     1 
ATOM   126  O  O     . GLU A 1 20  ? 109.071 136.768 167.744 1.00 176.89 ? 20  GLU A O     1 
ATOM   127  C  CB    . GLU A 1 20  ? 107.420 139.210 169.285 1.00 176.89 ? 20  GLU A CB    1 
ATOM   128  C  CG    . GLU A 1 20  ? 107.316 140.344 168.278 1.00 176.89 ? 20  GLU A CG    1 
ATOM   129  C  CD    . GLU A 1 20  ? 106.833 139.876 166.920 1.00 176.89 ? 20  GLU A CD    1 
ATOM   130  O  OE1   . GLU A 1 20  ? 106.069 138.890 166.867 1.00 176.89 ? 20  GLU A OE1   1 
ATOM   131  O  OE2   . GLU A 1 20  ? 107.219 140.494 165.905 1.00 176.89 ? 20  GLU A OE2   1 
ATOM   132  N  N     . ARG A 1 21  ? 109.796 138.823 167.171 1.00 167.11 ? 21  ARG A N     1 
ATOM   133  C  CA    . ARG A 1 21  ? 110.272 138.374 165.868 1.00 167.11 ? 21  ARG A CA    1 
ATOM   134  C  C     . ARG A 1 21  ? 111.430 137.395 166.010 1.00 167.11 ? 21  ARG A C     1 
ATOM   135  O  O     . ARG A 1 21  ? 111.512 136.411 165.268 1.00 167.11 ? 21  ARG A O     1 
ATOM   136  C  CB    . ARG A 1 21  ? 110.683 139.577 165.023 1.00 167.11 ? 21  ARG A CB    1 
ATOM   137  C  CG    . ARG A 1 21  ? 110.818 139.281 163.542 1.00 167.11 ? 21  ARG A CG    1 
ATOM   138  C  CD    . ARG A 1 21  ? 109.535 139.635 162.811 1.00 167.11 ? 21  ARG A CD    1 
ATOM   139  N  NE    . ARG A 1 21  ? 108.996 140.913 163.263 1.00 167.11 ? 21  ARG A NE    1 
ATOM   140  C  CZ    . ARG A 1 21  ? 109.192 142.070 162.647 1.00 167.11 ? 21  ARG A CZ    1 
ATOM   141  N  NH1   . ARG A 1 21  ? 109.907 142.149 161.537 1.00 167.11 ? 21  ARG A NH1   1 
ATOM   142  N  NH2   . ARG A 1 21  ? 108.657 143.175 163.158 1.00 167.11 ? 21  ARG A NH2   1 
ATOM   143  N  N     . ALA A 1 22  ? 112.338 137.653 166.956 1.00 168.78 ? 22  ALA A N     1 
ATOM   144  C  CA    . ALA A 1 22  ? 113.461 136.745 167.167 1.00 168.78 ? 22  ALA A CA    1 
ATOM   145  C  C     . ALA A 1 22  ? 112.986 135.382 167.655 1.00 168.78 ? 22  ALA A C     1 
ATOM   146  O  O     . ALA A 1 22  ? 113.503 134.346 167.224 1.00 168.78 ? 22  ALA A O     1 
ATOM   147  C  CB    . ALA A 1 22  ? 114.450 137.356 168.157 1.00 168.78 ? 22  ALA A CB    1 
ATOM   148  N  N     . MET A 1 23  ? 112.008 135.364 168.563 1.00 150.24 ? 23  MET A N     1 
ATOM   149  C  CA    . MET A 1 23  ? 111.473 134.091 169.036 1.00 150.24 ? 23  MET A CA    1 
ATOM   150  C  C     . MET A 1 23  ? 110.755 133.337 167.925 1.00 150.24 ? 23  MET A C     1 
ATOM   151  O  O     . MET A 1 23  ? 110.853 132.107 167.844 1.00 150.24 ? 23  MET A O     1 
ATOM   152  C  CB    . MET A 1 23  ? 110.535 134.310 170.219 1.00 150.24 ? 23  MET A CB    1 
ATOM   153  C  CG    . MET A 1 23  ? 110.350 133.064 171.061 1.00 150.24 ? 23  MET A CG    1 
ATOM   154  S  SD    . MET A 1 23  ? 109.882 133.413 172.760 1.00 150.24 ? 23  MET A SD    1 
ATOM   155  C  CE    . MET A 1 23  ? 111.460 133.156 173.558 1.00 150.24 ? 23  MET A CE    1 
ATOM   156  N  N     . LYS A 1 24  ? 110.021 134.050 167.068 1.00 174.06 ? 24  LYS A N     1 
ATOM   157  C  CA    . LYS A 1 24  ? 109.262 133.373 166.022 1.00 174.06 ? 24  LYS A CA    1 
ATOM   158  C  C     . LYS A 1 24  ? 110.175 132.636 165.048 1.00 174.06 ? 24  LYS A C     1 
ATOM   159  O  O     . LYS A 1 24  ? 109.881 131.503 164.650 1.00 174.06 ? 24  LYS A O     1 
ATOM   160  C  CB    . LYS A 1 24  ? 108.379 134.374 165.277 1.00 174.06 ? 24  LYS A CB    1 
ATOM   161  C  CG    . LYS A 1 24  ? 107.105 134.754 166.019 1.00 174.06 ? 24  LYS A CG    1 
ATOM   162  C  CD    . LYS A 1 24  ? 106.350 133.528 166.519 1.00 174.06 ? 24  LYS A CD    1 
ATOM   163  C  CE    . LYS A 1 24  ? 105.872 132.649 165.370 1.00 174.06 ? 24  LYS A CE    1 
ATOM   164  N  NZ    . LYS A 1 24  ? 105.032 133.403 164.399 1.00 174.06 ? 24  LYS A NZ    1 
ATOM   165  N  N     . LYS A 1 25  ? 111.286 133.255 164.655 1.00 183.57 ? 25  LYS A N     1 
ATOM   166  C  CA    . LYS A 1 25  ? 112.138 132.682 163.622 1.00 183.57 ? 25  LYS A CA    1 
ATOM   167  C  C     . LYS A 1 25  ? 113.570 133.152 163.833 1.00 183.57 ? 25  LYS A C     1 
ATOM   168  O  O     . LYS A 1 25  ? 113.818 134.196 164.442 1.00 183.57 ? 25  LYS A O     1 
ATOM   169  C  CB    . LYS A 1 25  ? 111.628 133.067 162.224 1.00 183.57 ? 25  LYS A CB    1 
ATOM   170  C  CG    . LYS A 1 25  ? 112.394 132.468 161.057 1.00 183.57 ? 25  LYS A CG    1 
ATOM   171  C  CD    . LYS A 1 25  ? 111.831 132.947 159.730 1.00 183.57 ? 25  LYS A CD    1 
ATOM   172  C  CE    . LYS A 1 25  ? 112.916 133.556 158.857 1.00 183.57 ? 25  LYS A CE    1 
ATOM   173  N  NZ    . LYS A 1 25  ? 114.167 132.750 158.880 1.00 183.57 ? 25  LYS A NZ    1 
ATOM   174  N  N     . ASN A 1 26  ? 114.516 132.362 163.325 1.00 162.67 ? 26  ASN A N     1 
ATOM   175  C  CA    . ASN A 1 26  ? 115.923 132.736 163.383 1.00 162.67 ? 26  ASN A CA    1 
ATOM   176  C  C     . ASN A 1 26  ? 116.152 134.022 162.600 1.00 162.67 ? 26  ASN A C     1 
ATOM   177  O  O     . ASN A 1 26  ? 115.725 134.143 161.448 1.00 162.67 ? 26  ASN A O     1 
ATOM   178  C  CB    . ASN A 1 26  ? 116.787 131.610 162.817 1.00 162.67 ? 26  ASN A CB    1 
ATOM   179  C  CG    . ASN A 1 26  ? 116.545 130.286 163.511 1.00 162.67 ? 26  ASN A CG    1 
ATOM   180  O  OD1   . ASN A 1 26  ? 115.429 129.992 163.935 1.00 162.67 ? 26  ASN A OD1   1 
ATOM   181  N  ND2   . ASN A 1 26  ? 117.590 129.478 163.625 1.00 162.67 ? 26  ASN A ND2   1 
ATOM   182  N  N     . THR A 1 27  ? 116.840 134.979 163.219 1.00 171.80 ? 27  THR A N     1 
ATOM   183  C  CA    . THR A 1 27  ? 116.972 136.306 162.637 1.00 171.80 ? 27  THR A CA    1 
ATOM   184  C  C     . THR A 1 27  ? 118.312 136.916 163.022 1.00 171.80 ? 27  THR A C     1 
ATOM   185  O  O     . THR A 1 27  ? 118.993 136.450 163.939 1.00 171.80 ? 27  THR A O     1 
ATOM   186  C  CB    . THR A 1 27  ? 115.835 137.236 163.081 1.00 171.80 ? 27  THR A CB    1 
ATOM   187  O  OG1   . THR A 1 27  ? 115.509 136.974 164.452 1.00 171.80 ? 27  THR A OG1   1 
ATOM   188  C  CG2   . THR A 1 27  ? 114.599 137.040 162.213 1.00 171.80 ? 27  THR A CG2   1 
ATOM   189  N  N     . ILE A 1 28  ? 118.677 137.974 162.301 1.00 163.26 ? 28  ILE A N     1 
ATOM   190  C  CA    . ILE A 1 28  ? 119.881 138.753 162.560 1.00 163.26 ? 28  ILE A CA    1 
ATOM   191  C  C     . ILE A 1 28  ? 119.459 140.180 162.881 1.00 163.26 ? 28  ILE A C     1 
ATOM   192  O  O     . ILE A 1 28  ? 118.692 140.788 162.125 1.00 163.26 ? 28  ILE A O     1 
ATOM   193  C  CB    . ILE A 1 28  ? 120.846 138.725 161.361 1.00 163.26 ? 28  ILE A CB    1 
ATOM   194  C  CG1   . ILE A 1 28  ? 121.373 137.309 161.131 1.00 163.26 ? 28  ILE A CG1   1 
ATOM   195  C  CG2   . ILE A 1 28  ? 122.001 139.686 161.583 1.00 163.26 ? 28  ILE A CG2   1 
ATOM   196  C  CD1   . ILE A 1 28  ? 122.092 137.141 159.814 1.00 163.26 ? 28  ILE A CD1   1 
ATOM   197  N  N     . VAL A 1 29  ? 119.960 140.710 163.992 1.00 178.66 ? 29  VAL A N     1 
ATOM   198  C  CA    . VAL A 1 29  ? 119.564 142.021 164.493 1.00 178.66 ? 29  VAL A CA    1 
ATOM   199  C  C     . VAL A 1 29  ? 120.544 143.068 163.983 1.00 178.66 ? 29  VAL A C     1 
ATOM   200  O  O     . VAL A 1 29  ? 121.757 142.951 164.197 1.00 178.66 ? 29  VAL A O     1 
ATOM   201  C  CB    . VAL A 1 29  ? 119.499 142.031 166.029 1.00 178.66 ? 29  VAL A CB    1 
ATOM   202  C  CG1   . VAL A 1 29  ? 119.402 143.456 166.547 1.00 178.66 ? 29  VAL A CG1   1 
ATOM   203  C  CG2   . VAL A 1 29  ? 118.322 141.204 166.515 1.00 178.66 ? 29  VAL A CG2   1 
ATOM   204  N  N     . CYS A 1 30  ? 120.020 144.092 163.314 1.00 186.62 ? 30  CYS A N     1 
ATOM   205  C  CA    . CYS A 1 30  ? 120.809 145.220 162.833 1.00 186.62 ? 30  CYS A CA    1 
ATOM   206  C  C     . CYS A 1 30  ? 120.312 146.484 163.521 1.00 186.62 ? 30  CYS A C     1 
ATOM   207  O  O     . CYS A 1 30  ? 119.189 146.932 163.265 1.00 186.62 ? 30  CYS A O     1 
ATOM   208  C  CB    . CYS A 1 30  ? 120.706 145.357 161.313 1.00 186.62 ? 30  CYS A CB    1 
ATOM   209  S  SG    . CYS A 1 30  ? 121.651 146.732 160.622 1.00 186.62 ? 30  CYS A SG    1 
ATOM   210  N  N     . LEU A 1 31  ? 121.148 147.059 164.381 1.00 181.48 ? 31  LEU A N     1 
ATOM   211  C  CA    . LEU A 1 31  ? 120.761 148.227 165.158 1.00 181.48 ? 31  LEU A CA    1 
ATOM   212  C  C     . LEU A 1 31  ? 121.949 149.166 165.291 1.00 181.48 ? 31  LEU A C     1 
ATOM   213  O  O     . LEU A 1 31  ? 123.105 148.765 165.139 1.00 181.48 ? 31  LEU A O     1 
ATOM   214  C  CB    . LEU A 1 31  ? 120.242 147.833 166.546 1.00 181.48 ? 31  LEU A CB    1 
ATOM   215  C  CG    . LEU A 1 31  ? 118.754 148.052 166.809 1.00 181.48 ? 31  LEU A CG    1 
ATOM   216  C  CD1   . LEU A 1 31  ? 118.389 147.595 168.210 1.00 181.48 ? 31  LEU A CD1   1 
ATOM   217  C  CD2   . LEU A 1 31  ? 118.402 149.516 166.616 1.00 181.48 ? 31  LEU A CD2   1 
ATOM   218  N  N     . GLY A 1 32  ? 121.645 150.430 165.576 1.00 157.57 ? 32  GLY A N     1 
ATOM   219  C  CA    . GLY A 1 32  ? 122.690 151.400 165.817 1.00 157.57 ? 32  GLY A CA    1 
ATOM   220  C  C     . GLY A 1 32  ? 123.406 151.155 167.130 1.00 157.57 ? 32  GLY A C     1 
ATOM   221  O  O     . GLY A 1 32  ? 122.894 150.511 168.046 1.00 157.57 ? 32  GLY A O     1 
ATOM   222  N  N     . THR A 1 33  ? 124.626 151.681 167.214 1.00 150.97 ? 33  THR A N     1 
ATOM   223  C  CA    . THR A 1 33  ? 125.434 151.494 168.410 1.00 150.97 ? 33  THR A CA    1 
ATOM   224  C  C     . THR A 1 33  ? 124.786 152.176 169.609 1.00 150.97 ? 33  THR A C     1 
ATOM   225  O  O     . THR A 1 33  ? 124.163 153.234 169.493 1.00 150.97 ? 33  THR A O     1 
ATOM   226  C  CB    . THR A 1 33  ? 126.847 152.037 168.191 1.00 150.97 ? 33  THR A CB    1 
ATOM   227  O  OG1   . THR A 1 33  ? 127.586 151.965 169.418 1.00 150.97 ? 33  THR A OG1   1 
ATOM   228  C  CG2   . THR A 1 33  ? 126.802 153.479 167.708 1.00 150.97 ? 33  THR A CG2   1 
ATOM   229  N  N     . GLY A 1 34  ? 124.929 151.548 170.774 1.00 155.58 ? 34  GLY A N     1 
ATOM   230  C  CA    . GLY A 1 34  ? 124.338 152.074 171.987 1.00 155.58 ? 34  GLY A CA    1 
ATOM   231  C  C     . GLY A 1 34  ? 122.872 151.766 172.174 1.00 155.58 ? 34  GLY A C     1 
ATOM   232  O  O     . GLY A 1 34  ? 122.284 152.203 173.167 1.00 155.58 ? 34  GLY A O     1 
ATOM   233  N  N     . SER A 1 35  ? 122.260 151.018 171.254 1.00 167.32 ? 35  SER A N     1 
ATOM   234  C  CA    . SER A 1 35  ? 120.840 150.704 171.340 1.00 167.32 ? 35  SER A CA    1 
ATOM   235  C  C     . SER A 1 35  ? 120.507 149.714 172.449 1.00 167.32 ? 35  SER A C     1 
ATOM   236  O  O     . SER A 1 35  ? 119.468 149.869 173.099 1.00 167.32 ? 35  SER A O     1 
ATOM   237  C  CB    . SER A 1 35  ? 120.343 150.158 169.999 1.00 167.32 ? 35  SER A CB    1 
ATOM   238  O  OG    . SER A 1 35  ? 121.132 149.062 169.570 1.00 167.32 ? 35  SER A OG    1 
ATOM   239  N  N     . GLY A 1 36  ? 121.352 148.713 172.686 1.00 170.47 ? 36  GLY A N     1 
ATOM   240  C  CA    . GLY A 1 36  ? 121.079 147.735 173.720 1.00 170.47 ? 36  GLY A CA    1 
ATOM   241  C  C     . GLY A 1 36  ? 120.706 146.359 173.206 1.00 170.47 ? 36  GLY A C     1 
ATOM   242  O  O     . GLY A 1 36  ? 119.827 145.699 173.769 1.00 170.47 ? 36  GLY A O     1 
ATOM   243  N  N     . LYS A 1 37  ? 121.366 145.915 172.134 1.00 156.98 ? 37  LYS A N     1 
ATOM   244  C  CA    . LYS A 1 37  ? 121.125 144.570 171.620 1.00 156.98 ? 37  LYS A CA    1 
ATOM   245  C  C     . LYS A 1 37  ? 121.538 143.505 172.628 1.00 156.98 ? 37  LYS A C     1 
ATOM   246  O  O     . LYS A 1 37  ? 120.986 142.395 172.622 1.00 156.98 ? 37  LYS A O     1 
ATOM   247  C  CB    . LYS A 1 37  ? 121.868 144.379 170.300 1.00 156.98 ? 37  LYS A CB    1 
ATOM   248  C  CG    . LYS A 1 37  ? 121.539 145.433 169.258 1.00 156.98 ? 37  LYS A CG    1 
ATOM   249  C  CD    . LYS A 1 37  ? 122.476 145.349 168.070 1.00 156.98 ? 37  LYS A CD    1 
ATOM   250  C  CE    . LYS A 1 37  ? 123.778 146.078 168.346 1.00 156.98 ? 37  LYS A CE    1 
ATOM   251  N  NZ    . LYS A 1 37  ? 124.019 147.168 167.364 1.00 156.98 ? 37  LYS A NZ    1 
ATOM   252  N  N     . THR A 1 38  ? 122.500 143.824 173.498 1.00 156.09 ? 38  THR A N     1 
ATOM   253  C  CA    . THR A 1 38  ? 122.872 142.900 174.562 1.00 156.09 ? 38  THR A CA    1 
ATOM   254  C  C     . THR A 1 38  ? 121.677 142.591 175.453 1.00 156.09 ? 38  THR A C     1 
ATOM   255  O  O     . THR A 1 38  ? 121.483 141.444 175.867 1.00 156.09 ? 38  THR A O     1 
ATOM   256  C  CB    . THR A 1 38  ? 124.021 143.483 175.385 1.00 156.09 ? 38  THR A CB    1 
ATOM   257  O  OG1   . THR A 1 38  ? 125.180 143.619 174.556 1.00 156.09 ? 38  THR A OG1   1 
ATOM   258  C  CG2   . THR A 1 38  ? 124.350 142.581 176.565 1.00 156.09 ? 38  THR A CG2   1 
ATOM   259  N  N     . PHE A 1 39  ? 120.851 143.598 175.742 1.00 162.74 ? 39  PHE A N     1 
ATOM   260  C  CA    . PHE A 1 39  ? 119.662 143.354 176.549 1.00 162.74 ? 39  PHE A CA    1 
ATOM   261  C  C     . PHE A 1 39  ? 118.642 142.507 175.797 1.00 162.74 ? 39  PHE A C     1 
ATOM   262  O  O     . PHE A 1 39  ? 117.917 141.713 176.409 1.00 162.74 ? 39  PHE A O     1 
ATOM   263  C  CB    . PHE A 1 39  ? 119.041 144.674 176.990 1.00 162.74 ? 39  PHE A CB    1 
ATOM   264  C  CG    . PHE A 1 39  ? 118.693 144.708 178.442 1.00 162.74 ? 39  PHE A CG    1 
ATOM   265  C  CD1   . PHE A 1 39  ? 119.683 144.823 179.400 1.00 162.74 ? 39  PHE A CD1   1 
ATOM   266  C  CD2   . PHE A 1 39  ? 117.379 144.599 178.851 1.00 162.74 ? 39  PHE A CD2   1 
ATOM   267  C  CE1   . PHE A 1 39  ? 119.366 144.846 180.738 1.00 162.74 ? 39  PHE A CE1   1 
ATOM   268  C  CE2   . PHE A 1 39  ? 117.057 144.617 180.187 1.00 162.74 ? 39  PHE A CE2   1 
ATOM   269  C  CZ    . PHE A 1 39  ? 118.048 144.745 181.133 1.00 162.74 ? 39  PHE A CZ    1 
ATOM   270  N  N     . ILE A 1 40  ? 118.567 142.663 174.475 1.00 147.45 ? 40  ILE A N     1 
ATOM   271  C  CA    . ILE A 1 40  ? 117.705 141.795 173.676 1.00 147.45 ? 40  ILE A CA    1 
ATOM   272  C  C     . ILE A 1 40  ? 118.148 140.346 173.823 1.00 147.45 ? 40  ILE A C     1 
ATOM   273  O  O     . ILE A 1 40  ? 117.330 139.440 174.037 1.00 147.45 ? 40  ILE A O     1 
ATOM   274  C  CB    . ILE A 1 40  ? 117.710 142.244 172.204 1.00 147.45 ? 40  ILE A CB    1 
ATOM   275  C  CG1   . ILE A 1 40  ? 116.868 143.506 172.029 1.00 147.45 ? 40  ILE A CG1   1 
ATOM   276  C  CG2   . ILE A 1 40  ? 117.202 141.133 171.300 1.00 147.45 ? 40  ILE A CG2   1 
ATOM   277  C  CD1   . ILE A 1 40  ? 116.817 144.006 170.607 1.00 147.45 ? 40  ILE A CD1   1 
ATOM   278  N  N     . ALA A 1 41  ? 119.460 140.110 173.727 1.00 141.78 ? 41  ALA A N     1 
ATOM   279  C  CA    . ALA A 1 41  ? 119.981 138.763 173.931 1.00 141.78 ? 41  ALA A CA    1 
ATOM   280  C  C     . ALA A 1 41  ? 119.685 138.264 175.340 1.00 141.78 ? 41  ALA A C     1 
ATOM   281  O  O     . ALA A 1 41  ? 119.338 137.092 175.531 1.00 141.78 ? 41  ALA A O     1 
ATOM   282  C  CB    . ALA A 1 41  ? 121.484 138.735 173.655 1.00 141.78 ? 41  ALA A CB    1 
ATOM   283  N  N     . VAL A 1 42  ? 119.813 139.142 176.337 1.00 158.30 ? 42  VAL A N     1 
ATOM   284  C  CA    . VAL A 1 42  ? 119.552 138.754 177.721 1.00 158.30 ? 42  VAL A CA    1 
ATOM   285  C  C     . VAL A 1 42  ? 118.111 138.292 177.882 1.00 158.30 ? 42  VAL A C     1 
ATOM   286  O  O     . VAL A 1 42  ? 117.835 137.247 178.484 1.00 158.30 ? 42  VAL A O     1 
ATOM   287  C  CB    . VAL A 1 42  ? 119.871 139.919 178.677 1.00 158.30 ? 42  VAL A CB    1 
ATOM   288  C  CG1   . VAL A 1 42  ? 119.302 139.642 180.060 1.00 158.30 ? 42  VAL A CG1   1 
ATOM   289  C  CG2   . VAL A 1 42  ? 121.366 140.152 178.754 1.00 158.30 ? 42  VAL A CG2   1 
ATOM   290  N  N     . MET A 1 43  ? 117.168 139.067 177.344 1.00 165.36 ? 43  MET A N     1 
ATOM   291  C  CA    . MET A 1 43  ? 115.757 138.720 177.483 1.00 165.36 ? 43  MET A CA    1 
ATOM   292  C  C     . MET A 1 43  ? 115.451 137.421 176.741 1.00 165.36 ? 43  MET A C     1 
ATOM   293  O  O     . MET A 1 43  ? 114.757 136.542 177.272 1.00 165.36 ? 43  MET A O     1 
ATOM   294  C  CB    . MET A 1 43  ? 114.899 139.887 176.977 1.00 165.36 ? 43  MET A CB    1 
ATOM   295  C  CG    . MET A 1 43  ? 113.514 139.589 176.385 1.00 165.36 ? 43  MET A CG    1 
ATOM   296  S  SD    . MET A 1 43  ? 112.430 138.385 177.198 1.00 165.36 ? 43  MET A SD    1 
ATOM   297  C  CE    . MET A 1 43  ? 112.518 138.912 178.909 1.00 165.36 ? 43  MET A CE    1 
ATOM   298  N  N     . LEU A 1 44  ? 115.997 137.264 175.529 1.00 130.53 ? 44  LEU A N     1 
ATOM   299  C  CA    . LEU A 1 44  ? 115.780 136.031 174.776 1.00 130.53 ? 44  LEU A CA    1 
ATOM   300  C  C     . LEU A 1 44  ? 116.306 134.820 175.534 1.00 130.53 ? 44  LEU A C     1 
ATOM   301  O  O     . LEU A 1 44  ? 115.682 133.754 175.528 1.00 130.53 ? 44  LEU A O     1 
ATOM   302  C  CB    . LEU A 1 44  ? 116.442 136.128 173.402 1.00 130.53 ? 44  LEU A CB    1 
ATOM   303  C  CG    . LEU A 1 44  ? 115.926 135.171 172.326 1.00 130.53 ? 44  LEU A CG    1 
ATOM   304  C  CD1   . LEU A 1 44  ? 114.443 134.911 172.498 1.00 130.53 ? 44  LEU A CD1   1 
ATOM   305  C  CD2   . LEU A 1 44  ? 116.217 135.712 170.937 1.00 130.53 ? 44  LEU A CD2   1 
ATOM   306  N  N     . ILE A 1 45  ? 117.461 134.963 176.188 1.00 134.09 ? 45  ILE A N     1 
ATOM   307  C  CA    . ILE A 1 45  ? 117.987 133.883 177.018 1.00 134.09 ? 45  ILE A CA    1 
ATOM   308  C  C     . ILE A 1 45  ? 117.048 133.603 178.184 1.00 134.09 ? 45  ILE A C     1 
ATOM   309  O  O     . ILE A 1 45  ? 116.749 132.445 178.498 1.00 134.09 ? 45  ILE A O     1 
ATOM   310  C  CB    . ILE A 1 45  ? 119.404 134.229 177.508 1.00 134.09 ? 45  ILE A CB    1 
ATOM   311  C  CG1   . ILE A 1 45  ? 120.418 134.060 176.378 1.00 134.09 ? 45  ILE A CG1   1 
ATOM   312  C  CG2   . ILE A 1 45  ? 119.785 133.363 178.698 1.00 134.09 ? 45  ILE A CG2   1 
ATOM   313  C  CD1   . ILE A 1 45  ? 120.395 132.698 175.749 1.00 134.09 ? 45  ILE A CD1   1 
ATOM   314  N  N     . LYS A 1 46  ? 116.565 134.660 178.841 1.00 157.17 ? 46  LYS A N     1 
ATOM   315  C  CA    . LYS A 1 46  ? 115.751 134.484 180.041 1.00 157.17 ? 46  LYS A CA    1 
ATOM   316  C  C     . LYS A 1 46  ? 114.410 133.831 179.735 1.00 157.17 ? 46  LYS A C     1 
ATOM   317  O  O     . LYS A 1 46  ? 113.840 133.162 180.604 1.00 157.17 ? 46  LYS A O     1 
ATOM   318  C  CB    . LYS A 1 46  ? 115.530 135.829 180.731 1.00 157.17 ? 46  LYS A CB    1 
ATOM   319  C  CG    . LYS A 1 46  ? 116.787 136.439 181.321 1.00 157.17 ? 46  LYS A CG    1 
ATOM   320  C  CD    . LYS A 1 46  ? 116.468 137.691 182.119 1.00 157.17 ? 46  LYS A CD    1 
ATOM   321  C  CE    . LYS A 1 46  ? 115.809 137.345 183.442 1.00 157.17 ? 46  LYS A CE    1 
ATOM   322  N  NZ    . LYS A 1 46  ? 116.737 136.608 184.342 1.00 157.17 ? 46  LYS A NZ    1 
ATOM   323  N  N     . GLU A 1 47  ? 113.885 134.013 178.522 1.00 151.86 ? 47  GLU A N     1 
ATOM   324  C  CA    . GLU A 1 47  ? 112.542 133.513 178.239 1.00 151.86 ? 47  GLU A CA    1 
ATOM   325  C  C     . GLU A 1 47  ? 112.513 131.990 178.119 1.00 151.86 ? 47  GLU A C     1 
ATOM   326  O  O     . GLU A 1 47  ? 111.547 131.352 178.550 1.00 151.86 ? 47  GLU A O     1 
ATOM   327  C  CB    . GLU A 1 47  ? 111.992 134.163 176.971 1.00 151.86 ? 47  GLU A CB    1 
ATOM   328  C  CG    . GLU A 1 47  ? 110.490 133.995 176.803 1.00 151.86 ? 47  GLU A CG    1 
ATOM   329  C  CD    . GLU A 1 47  ? 109.690 134.822 177.792 1.00 151.86 ? 47  GLU A CD    1 
ATOM   330  O  OE1   . GLU A 1 47  ? 110.255 135.771 178.374 1.00 151.86 ? 47  GLU A OE1   1 
ATOM   331  O  OE2   . GLU A 1 47  ? 108.494 134.522 177.987 1.00 151.86 ? 47  GLU A OE2   1 
ATOM   332  N  N     . LEU A 1 48  ? 113.553 131.390 177.542 1.00 143.14 ? 48  LEU A N     1 
ATOM   333  C  CA    . LEU A 1 48  ? 113.600 129.947 177.293 1.00 143.14 ? 48  LEU A CA    1 
ATOM   334  C  C     . LEU A 1 48  ? 114.437 129.202 178.325 1.00 143.14 ? 48  LEU A C     1 
ATOM   335  O  O     . LEU A 1 48  ? 115.144 128.251 177.984 1.00 143.14 ? 48  LEU A O     1 
ATOM   336  C  CB    . LEU A 1 48  ? 114.122 129.663 175.888 1.00 143.14 ? 48  LEU A CB    1 
ATOM   337  C  CG    . LEU A 1 48  ? 113.380 130.298 174.714 1.00 143.14 ? 48  LEU A CG    1 
ATOM   338  C  CD1   . LEU A 1 48  ? 114.221 130.225 173.451 1.00 143.14 ? 48  LEU A CD1   1 
ATOM   339  C  CD2   . LEU A 1 48  ? 112.041 129.615 174.505 1.00 143.14 ? 48  LEU A CD2   1 
ATOM   340  N  N     . ALA A 1 49  ? 114.381 129.603 179.591 1.00 141.86 ? 49  ALA A N     1 
ATOM   341  C  CA    . ALA A 1 49  ? 115.242 129.021 180.612 1.00 141.86 ? 49  ALA A CA    1 
ATOM   342  C  C     . ALA A 1 49  ? 114.725 127.701 181.171 1.00 141.86 ? 49  ALA A C     1 
ATOM   343  O  O     . ALA A 1 49  ? 115.408 127.097 182.003 1.00 141.86 ? 49  ALA A O     1 
ATOM   344  C  CB    . ALA A 1 49  ? 115.439 130.016 181.759 1.00 141.86 ? 49  ALA A CB    1 
ATOM   345  N  N     . HIS A 1 50  ? 113.545 127.237 180.751 1.00 154.60 ? 50  HIS A N     1 
ATOM   346  C  CA    . HIS A 1 50  ? 112.981 126.031 181.353 1.00 154.60 ? 50  HIS A CA    1 
ATOM   347  C  C     . HIS A 1 50  ? 113.743 124.778 180.930 1.00 154.60 ? 50  HIS A C     1 
ATOM   348  O  O     . HIS A 1 50  ? 113.941 123.866 181.742 1.00 154.60 ? 50  HIS A O     1 
ATOM   349  C  CB    . HIS A 1 50  ? 111.499 125.904 180.999 1.00 154.60 ? 50  HIS A CB    1 
ATOM   350  C  CG    . HIS A 1 50  ? 111.195 126.153 179.556 1.00 154.60 ? 50  HIS A CG    1 
ATOM   351  N  ND1   . HIS A 1 50  ? 111.013 127.418 179.041 1.00 154.60 ? 50  HIS A ND1   1 
ATOM   352  C  CD2   . HIS A 1 50  ? 111.031 125.298 178.518 1.00 154.60 ? 50  HIS A CD2   1 
ATOM   353  C  CE1   . HIS A 1 50  ? 110.755 127.332 177.748 1.00 154.60 ? 50  HIS A CE1   1 
ATOM   354  N  NE2   . HIS A 1 50  ? 110.760 126.056 177.406 1.00 154.60 ? 50  HIS A NE2   1 
ATOM   355  N  N     . GLU A 1 51  ? 114.175 124.709 179.668 1.00 136.18 ? 51  GLU A N     1 
ATOM   356  C  CA    . GLU A 1 51  ? 114.830 123.501 179.173 1.00 136.18 ? 51  GLU A CA    1 
ATOM   357  C  C     . GLU A 1 51  ? 116.183 123.269 179.831 1.00 136.18 ? 51  GLU A C     1 
ATOM   358  O  O     . GLU A 1 51  ? 116.617 122.118 179.961 1.00 136.18 ? 51  GLU A O     1 
ATOM   359  C  CB    . GLU A 1 51  ? 114.998 123.575 177.657 1.00 136.18 ? 51  GLU A CB    1 
ATOM   360  C  CG    . GLU A 1 51  ? 113.707 123.800 176.898 1.00 136.18 ? 51  GLU A CG    1 
ATOM   361  C  CD    . GLU A 1 51  ? 113.941 124.398 175.528 1.00 136.18 ? 51  GLU A CD    1 
ATOM   362  O  OE1   . GLU A 1 51  ? 114.950 124.038 174.888 1.00 136.18 ? 51  GLU A OE1   1 
ATOM   363  O  OE2   . GLU A 1 51  ? 113.115 125.225 175.089 1.00 136.18 ? 51  GLU A OE2   1 
ATOM   364  N  N     . ILE A 1 52  ? 116.863 124.338 180.249 1.00 134.91 ? 52  ILE A N     1 
ATOM   365  C  CA    . ILE A 1 52  ? 118.207 124.210 180.799 1.00 134.91 ? 52  ILE A CA    1 
ATOM   366  C  C     . ILE A 1 52  ? 118.214 123.473 182.134 1.00 134.91 ? 52  ILE A C     1 
ATOM   367  O  O     . ILE A 1 52  ? 119.254 122.944 182.541 1.00 134.91 ? 52  ILE A O     1 
ATOM   368  C  CB    . ILE A 1 52  ? 118.842 125.609 180.928 1.00 134.91 ? 52  ILE A CB    1 
ATOM   369  C  CG1   . ILE A 1 52  ? 118.674 126.384 179.621 1.00 134.91 ? 52  ILE A CG1   1 
ATOM   370  C  CG2   . ILE A 1 52  ? 120.319 125.511 181.259 1.00 134.91 ? 52  ILE A CG2   1 
ATOM   371  C  CD1   . ILE A 1 52  ? 119.330 125.718 178.435 1.00 134.91 ? 52  ILE A CD1   1 
ATOM   372  N  N     . ARG A 1 53  ? 117.070 123.402 182.819 1.00 158.78 ? 53  ARG A N     1 
ATOM   373  C  CA    . ARG A 1 53  ? 117.026 122.791 184.143 1.00 158.78 ? 53  ARG A CA    1 
ATOM   374  C  C     . ARG A 1 53  ? 117.336 121.298 184.120 1.00 158.78 ? 53  ARG A C     1 
ATOM   375  O  O     . ARG A 1 53  ? 117.712 120.743 185.158 1.00 158.78 ? 53  ARG A O     1 
ATOM   376  C  CB    . ARG A 1 53  ? 115.653 123.019 184.778 1.00 158.78 ? 53  ARG A CB    1 
ATOM   377  C  CG    . ARG A 1 53  ? 115.293 124.483 184.988 1.00 158.78 ? 53  ARG A CG    1 
ATOM   378  C  CD    . ARG A 1 53  ? 116.484 125.288 185.490 1.00 158.78 ? 53  ARG A CD    1 
ATOM   379  N  NE    . ARG A 1 53  ? 116.075 126.503 186.183 1.00 158.78 ? 53  ARG A NE    1 
ATOM   380  C  CZ    . ARG A 1 53  ? 115.582 127.581 185.588 1.00 158.78 ? 53  ARG A CZ    1 
ATOM   381  N  NH1   . ARG A 1 53  ? 115.432 127.639 184.274 1.00 158.78 ? 53  ARG A NH1   1 
ATOM   382  N  NH2   . ARG A 1 53  ? 115.236 128.630 186.329 1.00 158.78 ? 53  ARG A NH2   1 
ATOM   383  N  N     . GLY A 1 54  ? 117.191 120.638 182.973 1.00 165.18 ? 54  GLY A N     1 
ATOM   384  C  CA    . GLY A 1 54  ? 117.385 119.210 182.882 1.00 165.18 ? 54  GLY A CA    1 
ATOM   385  C  C     . GLY A 1 54  ? 118.820 118.777 183.107 1.00 165.18 ? 54  GLY A C     1 
ATOM   386  O  O     . GLY A 1 54  ? 119.771 119.497 182.787 1.00 165.18 ? 54  GLY A O     1 
ATOM   387  N  N     . PRO A 1 55  ? 119.001 117.584 183.672 1.00 168.70 ? 55  PRO A N     1 
ATOM   388  C  CA    . PRO A 1 55  ? 120.358 117.068 183.884 1.00 168.70 ? 55  PRO A CA    1 
ATOM   389  C  C     . PRO A 1 55  ? 121.036 116.714 182.570 1.00 168.70 ? 55  PRO A C     1 
ATOM   390  O  O     . PRO A 1 55  ? 120.388 116.358 181.583 1.00 168.70 ? 55  PRO A O     1 
ATOM   391  C  CB    . PRO A 1 55  ? 120.131 115.821 184.746 1.00 168.70 ? 55  PRO A CB    1 
ATOM   392  C  CG    . PRO A 1 55  ? 118.752 115.380 184.398 1.00 168.70 ? 55  PRO A CG    1 
ATOM   393  C  CD    . PRO A 1 55  ? 117.969 116.635 184.123 1.00 168.70 ? 55  PRO A CD    1 
ATOM   394  N  N     . PHE A 1 56  ? 122.366 116.815 182.573 1.00 163.18 ? 56  PHE A N     1 
ATOM   395  C  CA    . PHE A 1 56  ? 123.129 116.529 181.362 1.00 163.18 ? 56  PHE A CA    1 
ATOM   396  C  C     . PHE A 1 56  ? 123.086 115.048 181.006 1.00 163.18 ? 56  PHE A C     1 
ATOM   397  O  O     . PHE A 1 56  ? 122.974 114.691 179.828 1.00 163.18 ? 56  PHE A O     1 
ATOM   398  C  CB    . PHE A 1 56  ? 124.575 116.995 181.529 1.00 163.18 ? 56  PHE A CB    1 
ATOM   399  C  CG    . PHE A 1 56  ? 125.167 117.577 180.281 1.00 163.18 ? 56  PHE A CG    1 
ATOM   400  C  CD1   . PHE A 1 56  ? 125.212 116.839 179.111 1.00 163.18 ? 56  PHE A CD1   1 
ATOM   401  C  CD2   . PHE A 1 56  ? 125.674 118.865 180.275 1.00 163.18 ? 56  PHE A CD2   1 
ATOM   402  C  CE1   . PHE A 1 56  ? 125.754 117.372 177.960 1.00 163.18 ? 56  PHE A CE1   1 
ATOM   403  C  CE2   . PHE A 1 56  ? 126.216 119.403 179.125 1.00 163.18 ? 56  PHE A CE2   1 
ATOM   404  C  CZ    . PHE A 1 56  ? 126.255 118.655 177.967 1.00 163.18 ? 56  PHE A CZ    1 
ATOM   405  N  N     . ASN A 1 57  ? 123.178 114.171 182.011 1.00 184.83 ? 57  ASN A N     1 
ATOM   406  C  CA    . ASN A 1 57  ? 123.213 112.737 181.740 1.00 184.83 ? 57  ASN A CA    1 
ATOM   407  C  C     . ASN A 1 57  ? 121.924 112.248 181.097 1.00 184.83 ? 57  ASN A C     1 
ATOM   408  O  O     . ASN A 1 57  ? 121.929 111.234 180.389 1.00 184.83 ? 57  ASN A O     1 
ATOM   409  C  CB    . ASN A 1 57  ? 123.488 111.966 183.032 1.00 184.83 ? 57  ASN A CB    1 
ATOM   410  C  CG    . ASN A 1 57  ? 124.865 112.252 183.598 1.00 184.83 ? 57  ASN A CG    1 
ATOM   411  O  OD1   . ASN A 1 57  ? 125.717 112.829 182.925 1.00 184.83 ? 57  ASN A OD1   1 
ATOM   412  N  ND2   . ASN A 1 57  ? 125.089 111.847 184.842 1.00 184.83 ? 57  ASN A ND2   1 
ATOM   413  N  N     . GLU A 1 58  ? 120.816 112.948 181.324 1.00 187.52 ? 58  GLU A N     1 
ATOM   414  C  CA    . GLU A 1 58  ? 119.532 112.584 180.742 1.00 187.52 ? 58  GLU A CA    1 
ATOM   415  C  C     . GLU A 1 58  ? 119.251 113.302 179.430 1.00 187.52 ? 58  GLU A C     1 
ATOM   416  O  O     . GLU A 1 58  ? 118.167 113.125 178.864 1.00 187.52 ? 58  GLU A O     1 
ATOM   417  C  CB    . GLU A 1 58  ? 118.403 112.865 181.737 1.00 187.52 ? 58  GLU A CB    1 
ATOM   418  C  CG    . GLU A 1 58  ? 118.110 111.715 182.691 1.00 187.52 ? 58  GLU A CG    1 
ATOM   419  C  CD    . GLU A 1 58  ? 119.364 111.122 183.304 1.00 187.52 ? 58  GLU A CD    1 
ATOM   420  O  OE1   . GLU A 1 58  ? 120.199 111.893 183.821 1.00 187.52 ? 58  GLU A OE1   1 
ATOM   421  O  OE2   . GLU A 1 58  ? 119.516 109.883 183.267 1.00 187.52 ? 58  GLU A OE2   1 
ATOM   422  N  N     . GLY A 1 59  ? 120.191 114.099 178.931 1.00 173.73 ? 59  GLY A N     1 
ATOM   423  C  CA    . GLY A 1 59  ? 120.015 114.800 177.679 1.00 173.73 ? 59  GLY A CA    1 
ATOM   424  C  C     . GLY A 1 59  ? 119.597 116.249 177.784 1.00 173.73 ? 59  GLY A C     1 
ATOM   425  O  O     . GLY A 1 59  ? 119.229 116.839 176.762 1.00 173.73 ? 59  GLY A O     1 
ATOM   426  N  N     . GLY A 1 60  ? 119.631 116.838 178.979 1.00 164.29 ? 60  GLY A N     1 
ATOM   427  C  CA    . GLY A 1 60  ? 119.296 118.240 179.135 1.00 164.29 ? 60  GLY A CA    1 
ATOM   428  C  C     . GLY A 1 60  ? 120.216 119.144 178.340 1.00 164.29 ? 60  GLY A C     1 
ATOM   429  O  O     . GLY A 1 60  ? 121.437 119.106 178.514 1.00 164.29 ? 60  GLY A O     1 
ATOM   430  N  N     . LYS A 1 61  ? 119.640 119.968 177.469 1.00 135.34 ? 61  LYS A N     1 
ATOM   431  C  CA    . LYS A 1 61  ? 120.438 120.773 176.561 1.00 135.34 ? 61  LYS A CA    1 
ATOM   432  C  C     . LYS A 1 61  ? 121.079 121.949 177.297 1.00 135.34 ? 61  LYS A C     1 
ATOM   433  O  O     . LYS A 1 61  ? 120.763 122.248 178.452 1.00 135.34 ? 61  LYS A O     1 
ATOM   434  C  CB    . LYS A 1 61  ? 119.580 121.266 175.397 1.00 135.34 ? 61  LYS A CB    1 
ATOM   435  C  CG    . LYS A 1 61  ? 118.727 120.178 174.764 1.00 135.34 ? 61  LYS A CG    1 
ATOM   436  C  CD    . LYS A 1 61  ? 118.217 120.598 173.398 1.00 135.34 ? 61  LYS A CD    1 
ATOM   437  C  CE    . LYS A 1 61  ? 117.682 119.407 172.621 1.00 135.34 ? 61  LYS A CE    1 
ATOM   438  N  NZ    . LYS A 1 61  ? 117.302 119.775 171.230 1.00 135.34 ? 61  LYS A NZ    1 
ATOM   439  N  N     . ARG A 1 62  ? 121.999 122.619 176.606 1.00 117.84 ? 62  ARG A N     1 
ATOM   440  C  CA    . ARG A 1 62  ? 122.728 123.747 177.167 1.00 117.84 ? 62  ARG A CA    1 
ATOM   441  C  C     . ARG A 1 62  ? 122.799 124.866 176.139 1.00 117.84 ? 62  ARG A C     1 
ATOM   442  O  O     . ARG A 1 62  ? 122.701 124.637 174.931 1.00 117.84 ? 62  ARG A O     1 
ATOM   443  C  CB    . ARG A 1 62  ? 124.140 123.346 177.609 1.00 117.84 ? 62  ARG A CB    1 
ATOM   444  C  CG    . ARG A 1 62  ? 124.171 122.351 178.753 1.00 117.84 ? 62  ARG A CG    1 
ATOM   445  C  CD    . ARG A 1 62  ? 123.552 122.937 180.008 1.00 117.84 ? 62  ARG A CD    1 
ATOM   446  N  NE    . ARG A 1 62  ? 123.497 121.967 181.094 1.00 117.84 ? 62  ARG A NE    1 
ATOM   447  C  CZ    . ARG A 1 62  ? 122.486 121.138 181.306 1.00 117.84 ? 62  ARG A CZ    1 
ATOM   448  N  NH1   . ARG A 1 62  ? 121.424 121.126 180.517 1.00 117.84 ? 62  ARG A NH1   1 
ATOM   449  N  NH2   . ARG A 1 62  ? 122.539 120.298 182.336 1.00 117.84 ? 62  ARG A NH2   1 
ATOM   450  N  N     . THR A 1 63  ? 122.979 126.087 176.636 1.00 97.13  ? 63  THR A N     1 
ATOM   451  C  CA    . THR A 1 63  ? 123.033 127.286 175.810 1.00 97.13  ? 63  THR A CA    1 
ATOM   452  C  C     . THR A 1 63  ? 124.423 127.902 175.889 1.00 97.13  ? 63  THR A C     1 
ATOM   453  O  O     . THR A 1 63  ? 124.959 128.097 176.984 1.00 97.13  ? 63  THR A O     1 
ATOM   454  C  CB    . THR A 1 63  ? 121.977 128.301 176.255 1.00 97.13  ? 63  THR A CB    1 
ATOM   455  O  OG1   . THR A 1 63  ? 120.700 127.927 175.727 1.00 97.13  ? 63  THR A OG1   1 
ATOM   456  C  CG2   . THR A 1 63  ? 122.333 129.692 175.768 1.00 97.13  ? 63  THR A CG2   1 
ATOM   457  N  N     . PHE A 1 64  ? 124.997 128.211 174.730 1.00 97.14  ? 64  PHE A N     1 
ATOM   458  C  CA    . PHE A 1 64  ? 126.354 128.725 174.629 1.00 97.14  ? 64  PHE A CA    1 
ATOM   459  C  C     . PHE A 1 64  ? 126.346 130.179 174.175 1.00 97.14  ? 64  PHE A C     1 
ATOM   460  O  O     . PHE A 1 64  ? 125.408 130.638 173.519 1.00 97.14  ? 64  PHE A O     1 
ATOM   461  C  CB    . PHE A 1 64  ? 127.181 127.897 173.643 1.00 97.14  ? 64  PHE A CB    1 
ATOM   462  C  CG    . PHE A 1 64  ? 127.671 126.596 174.203 1.00 97.14  ? 64  PHE A CG    1 
ATOM   463  C  CD1   . PHE A 1 64  ? 126.794 125.553 174.432 1.00 97.14  ? 64  PHE A CD1   1 
ATOM   464  C  CD2   . PHE A 1 64  ? 129.011 126.412 174.484 1.00 97.14  ? 64  PHE A CD2   1 
ATOM   465  C  CE1   . PHE A 1 64  ? 127.243 124.353 174.941 1.00 97.14  ? 64  PHE A CE1   1 
ATOM   466  C  CE2   . PHE A 1 64  ? 129.466 125.215 174.991 1.00 97.14  ? 64  PHE A CE2   1 
ATOM   467  C  CZ    . PHE A 1 64  ? 128.580 124.184 175.221 1.00 97.14  ? 64  PHE A CZ    1 
ATOM   468  N  N     . PHE A 1 65  ? 127.408 130.898 174.535 1.00 120.18 ? 65  PHE A N     1 
ATOM   469  C  CA    . PHE A 1 65  ? 127.646 132.256 174.065 1.00 120.18 ? 65  PHE A CA    1 
ATOM   470  C  C     . PHE A 1 65  ? 129.093 132.366 173.611 1.00 120.18 ? 65  PHE A C     1 
ATOM   471  O  O     . PHE A 1 65  ? 130.008 132.005 174.357 1.00 120.18 ? 65  PHE A O     1 
ATOM   472  C  CB    . PHE A 1 65  ? 127.352 133.287 175.159 1.00 120.18 ? 65  PHE A CB    1 
ATOM   473  C  CG    . PHE A 1 65  ? 126.952 134.638 174.632 1.00 120.18 ? 65  PHE A CG    1 
ATOM   474  C  CD1   . PHE A 1 65  ? 127.847 135.409 173.912 1.00 120.18 ? 65  PHE A CD1   1 
ATOM   475  C  CD2   . PHE A 1 65  ? 125.684 135.141 174.869 1.00 120.18 ? 65  PHE A CD2   1 
ATOM   476  C  CE1   . PHE A 1 65  ? 127.484 136.653 173.430 1.00 120.18 ? 65  PHE A CE1   1 
ATOM   477  C  CE2   . PHE A 1 65  ? 125.316 136.384 174.391 1.00 120.18 ? 65  PHE A CE2   1 
ATOM   478  C  CZ    . PHE A 1 65  ? 126.217 137.140 173.671 1.00 120.18 ? 65  PHE A CZ    1 
ATOM   479  N  N     . LEU A 1 66  ? 129.297 132.869 172.397 1.00 120.16 ? 66  LEU A N     1 
ATOM   480  C  CA    . LEU A 1 66  ? 130.622 132.993 171.808 1.00 120.16 ? 66  LEU A CA    1 
ATOM   481  C  C     . LEU A 1 66  ? 130.920 134.458 171.528 1.00 120.16 ? 66  LEU A C     1 
ATOM   482  O  O     . LEU A 1 66  ? 130.032 135.210 171.118 1.00 120.16 ? 66  LEU A O     1 
ATOM   483  C  CB    . LEU A 1 66  ? 130.738 132.180 170.512 1.00 120.16 ? 66  LEU A CB    1 
ATOM   484  C  CG    . LEU A 1 66  ? 130.684 130.652 170.588 1.00 120.16 ? 66  LEU A CG    1 
ATOM   485  C  CD1   . LEU A 1 66  ? 131.591 130.052 169.530 1.00 120.16 ? 66  LEU A CD1   1 
ATOM   486  C  CD2   . LEU A 1 66  ? 131.087 130.145 171.962 1.00 120.16 ? 66  LEU A CD2   1 
ATOM   487  N  N     . VAL A 1 67  ? 132.172 134.859 171.753 1.00 124.44 ? 67  VAL A N     1 
ATOM   488  C  CA    . VAL A 1 67  ? 132.607 136.235 171.552 1.00 124.44 ? 67  VAL A CA    1 
ATOM   489  C  C     . VAL A 1 67  ? 134.009 136.210 170.951 1.00 124.44 ? 67  VAL A C     1 
ATOM   490  O  O     . VAL A 1 67  ? 134.682 135.177 170.932 1.00 124.44 ? 67  VAL A O     1 
ATOM   491  C  CB    . VAL A 1 67  ? 132.578 137.045 172.867 1.00 124.44 ? 67  VAL A CB    1 
ATOM   492  C  CG1   . VAL A 1 67  ? 133.718 136.631 173.779 1.00 124.44 ? 67  VAL A CG1   1 
ATOM   493  C  CG2   . VAL A 1 67  ? 132.556 138.538 172.595 1.00 124.44 ? 67  VAL A CG2   1 
ATOM   494  N  N     . ASN A 1 68  ? 134.451 137.369 170.459 1.00 131.56 ? 68  ASN A N     1 
ATOM   495  C  CA    . ASN A 1 68  ? 135.647 137.429 169.623 1.00 131.56 ? 68  ASN A CA    1 
ATOM   496  C  C     . ASN A 1 68  ? 136.935 137.428 170.444 1.00 131.56 ? 68  ASN A C     1 
ATOM   497  O  O     . ASN A 1 68  ? 137.749 136.506 170.335 1.00 131.56 ? 68  ASN A O     1 
ATOM   498  C  CB    . ASN A 1 68  ? 135.586 138.668 168.726 1.00 131.56 ? 68  ASN A CB    1 
ATOM   499  C  CG    . ASN A 1 68  ? 136.448 138.534 167.489 1.00 131.56 ? 68  ASN A CG    1 
ATOM   500  O  OD1   . ASN A 1 68  ? 137.343 137.694 167.432 1.00 131.56 ? 68  ASN A OD1   1 
ATOM   501  N  ND2   . ASN A 1 68  ? 136.178 139.363 166.489 1.00 131.56 ? 68  ASN A ND2   1 
ATOM   502  N  N     . THR A 1 69  ? 137.143 138.453 171.266 1.00 117.34 ? 69  THR A N     1 
ATOM   503  C  CA    . THR A 1 69  ? 138.417 138.656 171.944 1.00 117.34 ? 69  THR A CA    1 
ATOM   504  C  C     . THR A 1 69  ? 138.301 138.343 173.432 1.00 117.34 ? 69  THR A C     1 
ATOM   505  O  O     . THR A 1 69  ? 137.276 137.861 173.920 1.00 117.34 ? 69  THR A O     1 
ATOM   506  C  CB    . THR A 1 69  ? 138.925 140.087 171.742 1.00 117.34 ? 69  THR A CB    1 
ATOM   507  O  OG1   . THR A 1 69  ? 138.417 140.927 172.784 1.00 117.34 ? 69  THR A OG1   1 
ATOM   508  C  CG2   . THR A 1 69  ? 138.472 140.626 170.396 1.00 117.34 ? 69  THR A CG2   1 
ATOM   509  N  N     . VAL A 1 70  ? 139.387 138.631 174.155 1.00 119.93 ? 70  VAL A N     1 
ATOM   510  C  CA    . VAL A 1 70  ? 139.494 138.186 175.547 1.00 119.93 ? 70  VAL A CA    1 
ATOM   511  C  C     . VAL A 1 70  ? 138.696 139.056 176.514 1.00 119.93 ? 70  VAL A C     1 
ATOM   512  O  O     . VAL A 1 70  ? 137.891 138.503 177.281 1.00 119.93 ? 70  VAL A O     1 
ATOM   513  C  CB    . VAL A 1 70  ? 140.975 138.064 175.947 1.00 119.93 ? 70  VAL A CB    1 
ATOM   514  C  CG1   . VAL A 1 70  ? 141.097 137.526 177.361 1.00 119.93 ? 70  VAL A CG1   1 
ATOM   515  C  CG2   . VAL A 1 70  ? 141.715 137.174 174.966 1.00 119.93 ? 70  VAL A CG2   1 
ATOM   516  N  N     . PRO A 1 71  ? 138.875 140.384 176.563 1.00 121.84 ? 71  PRO A N     1 
ATOM   517  C  CA    . PRO A 1 71  ? 138.155 141.167 177.588 1.00 121.84 ? 71  PRO A CA    1 
ATOM   518  C  C     . PRO A 1 71  ? 136.642 141.081 177.478 1.00 121.84 ? 71  PRO A C     1 
ATOM   519  O  O     . PRO A 1 71  ? 135.942 141.164 178.498 1.00 121.84 ? 71  PRO A O     1 
ATOM   520  C  CB    . PRO A 1 71  ? 138.657 142.598 177.350 1.00 121.84 ? 71  PRO A CB    1 
ATOM   521  C  CG    . PRO A 1 71  ? 139.126 142.607 175.942 1.00 121.84 ? 71  PRO A CG    1 
ATOM   522  C  CD    . PRO A 1 71  ? 139.706 141.253 175.710 1.00 121.84 ? 71  PRO A CD    1 
ATOM   523  N  N     . LEU A 1 72  ? 136.114 140.922 176.264 1.00 129.06 ? 72  LEU A N     1 
ATOM   524  C  CA    . LEU A 1 72  ? 134.670 140.793 176.104 1.00 129.06 ? 72  LEU A CA    1 
ATOM   525  C  C     . LEU A 1 72  ? 134.139 139.556 176.815 1.00 129.06 ? 72  LEU A C     1 
ATOM   526  O  O     . LEU A 1 72  ? 132.969 139.528 177.213 1.00 129.06 ? 72  LEU A O     1 
ATOM   527  C  CB    . LEU A 1 72  ? 134.306 140.762 174.620 1.00 129.06 ? 72  LEU A CB    1 
ATOM   528  C  CG    . LEU A 1 72  ? 134.336 142.087 173.851 1.00 129.06 ? 72  LEU A CG    1 
ATOM   529  C  CD1   . LEU A 1 72  ? 135.754 142.494 173.487 1.00 129.06 ? 72  LEU A CD1   1 
ATOM   530  C  CD2   . LEU A 1 72  ? 133.470 142.009 172.603 1.00 129.06 ? 72  LEU A CD2   1 
ATOM   531  N  N     . VAL A 1 73  ? 134.985 138.539 177.004 1.00 126.21 ? 73  VAL A N     1 
ATOM   532  C  CA    . VAL A 1 73  ? 134.567 137.347 177.740 1.00 126.21 ? 73  VAL A CA    1 
ATOM   533  C  C     . VAL A 1 73  ? 134.123 137.726 179.145 1.00 126.21 ? 73  VAL A C     1 
ATOM   534  O  O     . VAL A 1 73  ? 133.075 137.284 179.626 1.00 126.21 ? 73  VAL A O     1 
ATOM   535  C  CB    . VAL A 1 73  ? 135.704 136.309 177.770 1.00 126.21 ? 73  VAL A CB    1 
ATOM   536  C  CG1   . VAL A 1 73  ? 135.527 135.354 178.938 1.00 126.21 ? 73  VAL A CG1   1 
ATOM   537  C  CG2   . VAL A 1 73  ? 135.769 135.546 176.463 1.00 126.21 ? 73  VAL A CG2   1 
ATOM   538  N  N     . ASN A 1 74  ? 134.911 138.563 179.821 1.00 151.53 ? 74  ASN A N     1 
ATOM   539  C  CA    . ASN A 1 74  ? 134.513 139.040 181.140 1.00 151.53 ? 74  ASN A CA    1 
ATOM   540  C  C     . ASN A 1 74  ? 133.375 140.048 181.038 1.00 151.53 ? 74  ASN A C     1 
ATOM   541  O  O     . ASN A 1 74  ? 132.457 140.047 181.870 1.00 151.53 ? 74  ASN A O     1 
ATOM   542  C  CB    . ASN A 1 74  ? 135.717 139.653 181.855 1.00 151.53 ? 74  ASN A CB    1 
ATOM   543  C  CG    . ASN A 1 74  ? 135.497 139.818 183.349 1.00 151.53 ? 74  ASN A CG    1 
ATOM   544  O  OD1   . ASN A 1 74  ? 134.365 139.819 183.830 1.00 151.53 ? 74  ASN A OD1   1 
ATOM   545  N  ND2   . ASN A 1 74  ? 136.588 139.961 184.091 1.00 151.53 ? 74  ASN A ND2   1 
ATOM   546  N  N     . GLN A 1 75  ? 133.416 140.909 180.017 1.00 151.12 ? 75  GLN A N     1 
ATOM   547  C  CA    . GLN A 1 75  ? 132.438 141.992 179.921 1.00 151.12 ? 75  GLN A CA    1 
ATOM   548  C  C     . GLN A 1 75  ? 131.015 141.453 179.799 1.00 151.12 ? 75  GLN A C     1 
ATOM   549  O  O     . GLN A 1 75  ? 130.125 141.845 180.564 1.00 151.12 ? 75  GLN A O     1 
ATOM   550  C  CB    . GLN A 1 75  ? 132.775 142.898 178.736 1.00 151.12 ? 75  GLN A CB    1 
ATOM   551  C  CG    . GLN A 1 75  ? 132.105 144.262 178.796 1.00 151.12 ? 75  GLN A CG    1 
ATOM   552  C  CD    . GLN A 1 75  ? 131.955 144.899 177.429 1.00 151.12 ? 75  GLN A CD    1 
ATOM   553  O  OE1   . GLN A 1 75  ? 132.720 145.790 177.060 1.00 151.12 ? 75  GLN A OE1   1 
ATOM   554  N  NE2   . GLN A 1 75  ? 130.965 144.445 176.671 1.00 151.12 ? 75  GLN A NE2   1 
ATOM   555  N  N     . GLN A 1 76  ? 130.780 140.550 178.845 1.00 138.24 ? 76  GLN A N     1 
ATOM   556  C  CA    . GLN A 1 76  ? 129.439 139.994 178.676 1.00 138.24 ? 76  GLN A CA    1 
ATOM   557  C  C     . GLN A 1 76  ? 129.050 139.093 179.843 1.00 138.24 ? 76  GLN A C     1 
ATOM   558  O  O     . GLN A 1 76  ? 127.876 139.064 180.239 1.00 138.24 ? 76  GLN A O     1 
ATOM   559  C  CB    . GLN A 1 76  ? 129.345 139.220 177.361 1.00 138.24 ? 76  GLN A CB    1 
ATOM   560  C  CG    . GLN A 1 76  ? 130.030 139.890 176.182 1.00 138.24 ? 76  GLN A CG    1 
ATOM   561  C  CD    . GLN A 1 76  ? 129.227 141.035 175.608 1.00 138.24 ? 76  GLN A CD    1 
ATOM   562  O  OE1   . GLN A 1 76  ? 129.439 142.195 175.960 1.00 138.24 ? 76  GLN A OE1   1 
ATOM   563  N  NE2   . GLN A 1 76  ? 128.302 140.718 174.710 1.00 138.24 ? 76  GLN A NE2   1 
ATOM   564  N  N     . ALA A 1 77  ? 130.011 138.345 180.389 1.00 140.86 ? 77  ALA A N     1 
ATOM   565  C  CA    . ALA A 1 77  ? 129.709 137.431 181.483 1.00 140.86 ? 77  ALA A CA    1 
ATOM   566  C  C     . ALA A 1 77  ? 129.229 138.182 182.716 1.00 140.86 ? 77  ALA A C     1 
ATOM   567  O  O     . ALA A 1 77  ? 128.310 137.727 183.405 1.00 140.86 ? 77  ALA A O     1 
ATOM   568  C  CB    . ALA A 1 77  ? 130.934 136.583 181.821 1.00 140.86 ? 77  ALA A CB    1 
ATOM   569  N  N     . LYS A 1 78  ? 129.842 139.330 183.016 1.00 149.77 ? 78  LYS A N     1 
ATOM   570  C  CA    . LYS A 1 78  ? 129.405 140.102 184.177 1.00 149.77 ? 78  LYS A CA    1 
ATOM   571  C  C     . LYS A 1 78  ? 127.964 140.572 184.017 1.00 149.77 ? 78  LYS A C     1 
ATOM   572  O  O     . LYS A 1 78  ? 127.171 140.500 184.963 1.00 149.77 ? 78  LYS A O     1 
ATOM   573  C  CB    . LYS A 1 78  ? 130.337 141.290 184.404 1.00 149.77 ? 78  LYS A CB    1 
ATOM   574  C  CG    . LYS A 1 78  ? 130.234 141.888 185.798 1.00 149.77 ? 78  LYS A CG    1 
ATOM   575  C  CD    . LYS A 1 78  ? 131.032 143.172 185.914 1.00 149.77 ? 78  LYS A CD    1 
ATOM   576  C  CE    . LYS A 1 78  ? 132.492 142.944 185.562 1.00 149.77 ? 78  LYS A CE    1 
ATOM   577  N  NZ    . LYS A 1 78  ? 133.235 142.301 186.681 1.00 149.77 ? 78  LYS A NZ    1 
ATOM   578  N  N     . VAL A 1 79  ? 127.604 141.046 182.822 1.00 147.41 ? 79  VAL A N     1 
ATOM   579  C  CA    . VAL A 1 79  ? 126.235 141.493 182.574 1.00 147.41 ? 79  VAL A CA    1 
ATOM   580  C  C     . VAL A 1 79  ? 125.263 140.329 182.720 1.00 147.41 ? 79  VAL A C     1 
ATOM   581  O  O     . VAL A 1 79  ? 124.219 140.441 183.380 1.00 147.41 ? 79  VAL A O     1 
ATOM   582  C  CB    . VAL A 1 79  ? 126.132 142.144 181.182 1.00 147.41 ? 79  VAL A CB    1 
ATOM   583  C  CG1   . VAL A 1 79  ? 124.683 142.215 180.730 1.00 147.41 ? 79  VAL A CG1   1 
ATOM   584  C  CG2   . VAL A 1 79  ? 126.762 143.525 181.195 1.00 147.41 ? 79  VAL A CG2   1 
ATOM   585  N  N     . ILE A 1 80  ? 125.597 139.188 182.110 1.00 144.23 ? 80  ILE A N     1 
ATOM   586  C  CA    . ILE A 1 80  ? 124.698 138.040 182.151 1.00 144.23 ? 80  ILE A CA    1 
ATOM   587  C  C     . ILE A 1 80  ? 124.543 137.526 183.577 1.00 144.23 ? 80  ILE A C     1 
ATOM   588  O  O     . ILE A 1 80  ? 123.464 137.056 183.960 1.00 144.23 ? 80  ILE A O     1 
ATOM   589  C  CB    . ILE A 1 80  ? 125.182 136.941 181.182 1.00 144.23 ? 80  ILE A CB    1 
ATOM   590  C  CG1   . ILE A 1 80  ? 123.997 136.321 180.444 1.00 144.23 ? 80  ILE A CG1   1 
ATOM   591  C  CG2   . ILE A 1 80  ? 125.974 135.858 181.900 1.00 144.23 ? 80  ILE A CG2   1 
ATOM   592  C  CD1   . ILE A 1 80  ? 123.315 137.264 179.491 1.00 144.23 ? 80  ILE A CD1   1 
ATOM   593  N  N     . ARG A 1 81  ? 125.601 137.607 184.387 1.00 155.18 ? 81  ARG A N     1 
ATOM   594  C  CA    . ARG A 1 81  ? 125.509 137.178 185.776 1.00 155.18 ? 81  ARG A CA    1 
ATOM   595  C  C     . ARG A 1 81  ? 124.693 138.156 186.607 1.00 155.18 ? 81  ARG A C     1 
ATOM   596  O  O     . ARG A 1 81  ? 123.935 137.742 187.491 1.00 155.18 ? 81  ARG A O     1 
ATOM   597  C  CB    . ARG A 1 81  ? 126.910 137.018 186.366 1.00 155.18 ? 81  ARG A CB    1 
ATOM   598  C  CG    . ARG A 1 81  ? 127.009 135.983 187.469 1.00 155.18 ? 81  ARG A CG    1 
ATOM   599  C  CD    . ARG A 1 81  ? 128.445 135.825 187.932 1.00 155.18 ? 81  ARG A CD    1 
ATOM   600  N  NE    . ARG A 1 81  ? 129.298 135.299 186.872 1.00 155.18 ? 81  ARG A NE    1 
ATOM   601  C  CZ    . ARG A 1 81  ? 130.394 135.896 186.428 1.00 155.18 ? 81  ARG A CZ    1 
ATOM   602  N  NH1   . ARG A 1 81  ? 130.803 137.051 186.927 1.00 155.18 ? 81  ARG A NH1   1 
ATOM   603  N  NH2   . ARG A 1 81  ? 131.096 135.323 185.454 1.00 155.18 ? 81  ARG A NH2   1 
ATOM   604  N  N     . LYS A 1 82  ? 124.834 139.456 186.339 1.00 178.19 ? 82  LYS A N     1 
ATOM   605  C  CA    . LYS A 1 82  ? 124.130 140.448 187.141 1.00 178.19 ? 82  LYS A CA    1 
ATOM   606  C  C     . LYS A 1 82  ? 122.633 140.439 186.856 1.00 178.19 ? 82  LYS A C     1 
ATOM   607  O  O     . LYS A 1 82  ? 121.821 140.518 187.785 1.00 178.19 ? 82  LYS A O     1 
ATOM   608  C  CB    . LYS A 1 82  ? 124.709 141.839 186.891 1.00 178.19 ? 82  LYS A CB    1 
ATOM   609  C  CG    . LYS A 1 82  ? 124.246 142.882 187.895 1.00 178.19 ? 82  LYS A CG    1 
ATOM   610  C  CD    . LYS A 1 82  ? 124.888 144.231 187.629 1.00 178.19 ? 82  LYS A CD    1 
ATOM   611  C  CE    . LYS A 1 82  ? 124.358 144.845 186.347 1.00 178.19 ? 82  LYS A CE    1 
ATOM   612  N  NZ    . LYS A 1 82  ? 122.915 145.191 186.467 1.00 178.19 ? 82  LYS A NZ    1 
ATOM   613  N  N     . HIS A 1 83  ? 122.244 140.345 185.585 1.00 168.44 ? 83  HIS A N     1 
ATOM   614  C  CA    . HIS A 1 83  ? 120.840 140.529 185.242 1.00 168.44 ? 83  HIS A CA    1 
ATOM   615  C  C     . HIS A 1 83  ? 120.014 139.249 185.296 1.00 168.44 ? 83  HIS A C     1 
ATOM   616  O  O     . HIS A 1 83  ? 118.787 139.325 185.178 1.00 168.44 ? 83  HIS A O     1 
ATOM   617  C  CB    . HIS A 1 83  ? 120.709 141.155 183.853 1.00 168.44 ? 83  HIS A CB    1 
ATOM   618  C  CG    . HIS A 1 83  ? 120.454 142.629 183.887 1.00 168.44 ? 83  HIS A CG    1 
ATOM   619  N  ND1   . HIS A 1 83  ? 121.456 143.552 184.092 1.00 168.44 ? 83  HIS A ND1   1 
ATOM   620  C  CD2   . HIS A 1 83  ? 119.306 143.336 183.782 1.00 168.44 ? 83  HIS A CD2   1 
ATOM   621  C  CE1   . HIS A 1 83  ? 120.940 144.768 184.086 1.00 168.44 ? 83  HIS A CE1   1 
ATOM   622  N  NE2   . HIS A 1 83  ? 119.635 144.665 183.902 1.00 168.44 ? 83  HIS A NE2   1 
ATOM   623  N  N     . THR A 1 84  ? 120.637 138.086 185.469 1.00 173.60 ? 84  THR A N     1 
ATOM   624  C  CA    . THR A 1 84  ? 119.912 136.825 185.528 1.00 173.60 ? 84  THR A CA    1 
ATOM   625  C  C     . THR A 1 84  ? 120.364 136.024 186.739 1.00 173.60 ? 84  THR A C     1 
ATOM   626  O  O     . THR A 1 84  ? 121.470 136.205 187.256 1.00 173.60 ? 84  THR A O     1 
ATOM   627  C  CB    . THR A 1 84  ? 120.111 135.981 184.258 1.00 173.60 ? 84  THR A CB    1 
ATOM   628  O  OG1   . THR A 1 84  ? 121.413 135.384 184.280 1.00 173.60 ? 84  THR A OG1   1 
ATOM   629  C  CG2   . THR A 1 84  ? 119.966 136.833 183.006 1.00 173.60 ? 84  THR A CG2   1 
ATOM   630  N  N     . SER A 1 85  ? 119.486 135.129 187.188 1.00 165.56 ? 85  SER A N     1 
ATOM   631  C  CA    . SER A 1 85  ? 119.801 134.219 188.279 1.00 165.56 ? 85  SER A CA    1 
ATOM   632  C  C     . SER A 1 85  ? 120.486 132.943 187.806 1.00 165.56 ? 85  SER A C     1 
ATOM   633  O  O     . SER A 1 85  ? 120.922 132.146 188.644 1.00 165.56 ? 85  SER A O     1 
ATOM   634  C  CB    . SER A 1 85  ? 118.528 133.854 189.048 1.00 165.56 ? 85  SER A CB    1 
ATOM   635  O  OG    . SER A 1 85  ? 118.810 132.947 190.099 1.00 165.56 ? 85  SER A OG    1 
ATOM   636  N  N     . LEU A 1 86  ? 120.589 132.733 186.496 1.00 156.64 ? 86  LEU A N     1 
ATOM   637  C  CA    . LEU A 1 86  ? 121.229 131.535 185.973 1.00 156.64 ? 86  LEU A CA    1 
ATOM   638  C  C     . LEU A 1 86  ? 122.727 131.564 186.243 1.00 156.64 ? 86  LEU A C     1 
ATOM   639  O  O     . LEU A 1 86  ? 123.361 132.622 186.207 1.00 156.64 ? 86  LEU A O     1 
ATOM   640  C  CB    . LEU A 1 86  ? 120.969 131.413 184.473 1.00 156.64 ? 86  LEU A CB    1 
ATOM   641  C  CG    . LEU A 1 86  ? 119.506 131.506 184.037 1.00 156.64 ? 86  LEU A CG    1 
ATOM   642  C  CD1   . LEU A 1 86  ? 119.398 131.520 182.521 1.00 156.64 ? 86  LEU A CD1   1 
ATOM   643  C  CD2   . LEU A 1 86  ? 118.699 130.362 184.626 1.00 156.64 ? 86  LEU A CD2   1 
ATOM   644  N  N     . LYS A 1 87  ? 123.294 130.393 186.514 1.00 152.64 ? 87  LYS A N     1 
ATOM   645  C  CA    . LYS A 1 87  ? 124.728 130.281 186.737 1.00 152.64 ? 87  LYS A CA    1 
ATOM   646  C  C     . LYS A 1 87  ? 125.463 130.247 185.404 1.00 152.64 ? 87  LYS A C     1 
ATOM   647  O  O     . LYS A 1 87  ? 125.044 129.567 184.463 1.00 152.64 ? 87  LYS A O     1 
ATOM   648  C  CB    . LYS A 1 87  ? 125.048 129.027 187.549 1.00 152.64 ? 87  LYS A CB    1 
ATOM   649  C  CG    . LYS A 1 87  ? 126.471 128.518 187.384 1.00 152.64 ? 87  LYS A CG    1 
ATOM   650  C  CD    . LYS A 1 87  ? 126.737 127.303 188.258 1.00 152.64 ? 87  LYS A CD    1 
ATOM   651  C  CE    . LYS A 1 87  ? 126.186 127.492 189.663 1.00 152.64 ? 87  LYS A CE    1 
ATOM   652  N  NZ    . LYS A 1 87  ? 126.805 128.658 190.350 1.00 152.64 ? 87  LYS A NZ    1 
ATOM   653  N  N     . VAL A 1 88  ? 126.567 130.986 185.328 1.00 146.40 ? 88  VAL A N     1 
ATOM   654  C  CA    . VAL A 1 88  ? 127.350 131.092 184.106 1.00 146.40 ? 88  VAL A CA    1 
ATOM   655  C  C     . VAL A 1 88  ? 128.777 130.643 184.391 1.00 146.40 ? 88  VAL A C     1 
ATOM   656  O  O     . VAL A 1 88  ? 129.261 130.726 185.524 1.00 146.40 ? 88  VAL A O     1 
ATOM   657  C  CB    . VAL A 1 88  ? 127.324 132.528 183.532 1.00 146.40 ? 88  VAL A CB    1 
ATOM   658  C  CG1   . VAL A 1 88  ? 128.217 133.451 184.346 1.00 146.40 ? 88  VAL A CG1   1 
ATOM   659  C  CG2   . VAL A 1 88  ? 127.725 132.532 182.064 1.00 146.40 ? 88  VAL A CG2   1 
ATOM   660  N  N     . GLY A 1 89  ? 129.443 130.144 183.354 1.00 135.02 ? 89  GLY A N     1 
ATOM   661  C  CA    . GLY A 1 89  ? 130.818 129.702 183.460 1.00 135.02 ? 89  GLY A CA    1 
ATOM   662  C  C     . GLY A 1 89  ? 131.714 130.508 182.539 1.00 135.02 ? 89  GLY A C     1 
ATOM   663  O  O     . GLY A 1 89  ? 131.274 131.013 181.505 1.00 135.02 ? 89  GLY A O     1 
ATOM   664  N  N     . GLU A 1 90  ? 132.981 130.626 182.926 1.00 143.25 ? 90  GLU A N     1 
ATOM   665  C  CA    . GLU A 1 90  ? 133.952 131.426 182.191 1.00 143.25 ? 90  GLU A CA    1 
ATOM   666  C  C     . GLU A 1 90  ? 135.213 130.611 181.961 1.00 143.25 ? 90  GLU A C     1 
ATOM   667  O  O     . GLU A 1 90  ? 135.789 130.071 182.911 1.00 143.25 ? 90  GLU A O     1 
ATOM   668  C  CB    . GLU A 1 90  ? 134.284 132.712 182.952 1.00 143.25 ? 90  GLU A CB    1 
ATOM   669  C  CG    . GLU A 1 90  ? 135.064 133.730 182.143 1.00 143.25 ? 90  GLU A CG    1 
ATOM   670  C  CD    . GLU A 1 90  ? 134.718 135.155 182.520 1.00 143.25 ? 90  GLU A CD    1 
ATOM   671  O  OE1   . GLU A 1 90  ? 133.704 135.356 183.222 1.00 143.25 ? 90  GLU A OE1   1 
ATOM   672  O  OE2   . GLU A 1 90  ? 135.458 136.076 182.116 1.00 143.25 ? 90  GLU A OE2   1 
ATOM   673  N  N     . TYR A 1 91  ? 135.644 130.530 180.703 1.00 141.01 ? 91  TYR A N     1 
ATOM   674  C  CA    . TYR A 1 91  ? 136.853 129.807 180.335 1.00 141.01 ? 91  TYR A CA    1 
ATOM   675  C  C     . TYR A 1 91  ? 137.556 130.532 179.201 1.00 141.01 ? 91  TYR A C     1 
ATOM   676  O  O     . TYR A 1 91  ? 136.918 130.948 178.230 1.00 141.01 ? 91  TYR A O     1 
ATOM   677  C  CB    . TYR A 1 91  ? 136.541 128.367 179.909 1.00 141.01 ? 91  TYR A CB    1 
ATOM   678  C  CG    . TYR A 1 91  ? 135.875 127.533 180.976 1.00 141.01 ? 91  TYR A CG    1 
ATOM   679  C  CD1   . TYR A 1 91  ? 136.551 127.190 182.138 1.00 141.01 ? 91  TYR A CD1   1 
ATOM   680  C  CD2   . TYR A 1 91  ? 134.571 127.086 180.820 1.00 141.01 ? 91  TYR A CD2   1 
ATOM   681  C  CE1   . TYR A 1 91  ? 135.947 126.428 183.117 1.00 141.01 ? 91  TYR A CE1   1 
ATOM   682  C  CE2   . TYR A 1 91  ? 133.959 126.322 181.793 1.00 141.01 ? 91  TYR A CE2   1 
ATOM   683  C  CZ    . TYR A 1 91  ? 134.651 125.996 182.939 1.00 141.01 ? 91  TYR A CZ    1 
ATOM   684  O  OH    . TYR A 1 91  ? 134.043 125.236 183.911 1.00 141.01 ? 91  TYR A OH    1 
ATOM   685  N  N     . VAL A 1 92  ? 138.874 130.677 179.328 1.00 134.92 ? 92  VAL A N     1 
ATOM   686  C  CA    . VAL A 1 92  ? 139.713 131.261 178.289 1.00 134.92 ? 92  VAL A CA    1 
ATOM   687  C  C     . VAL A 1 92  ? 141.005 130.453 178.226 1.00 134.92 ? 92  VAL A C     1 
ATOM   688  O  O     . VAL A 1 92  ? 141.257 129.577 179.055 1.00 134.92 ? 92  VAL A O     1 
ATOM   689  C  CB    . VAL A 1 92  ? 139.995 132.761 178.534 1.00 134.92 ? 92  VAL A CB    1 
ATOM   690  C  CG1   . VAL A 1 92  ? 141.147 132.955 179.510 1.00 134.92 ? 92  VAL A CG1   1 
ATOM   691  C  CG2   . VAL A 1 92  ? 140.243 133.495 177.219 1.00 134.92 ? 92  VAL A CG2   1 
ATOM   692  N  N     . GLY A 1 93  ? 141.827 130.752 177.220 1.00 149.76 ? 93  GLY A N     1 
ATOM   693  C  CA    . GLY A 1 93  ? 142.987 129.925 176.936 1.00 149.76 ? 93  GLY A CA    1 
ATOM   694  C  C     . GLY A 1 93  ? 144.126 130.057 177.925 1.00 149.76 ? 93  GLY A C     1 
ATOM   695  O  O     . GLY A 1 93  ? 145.090 129.291 177.840 1.00 149.76 ? 93  GLY A O     1 
ATOM   696  N  N     . ASP A 1 94  ? 144.045 131.012 178.854 1.00 180.97 ? 94  ASP A N     1 
ATOM   697  C  CA    . ASP A 1 94  ? 145.160 131.243 179.768 1.00 180.97 ? 94  ASP A CA    1 
ATOM   698  C  C     . ASP A 1 94  ? 145.392 130.051 180.691 1.00 180.97 ? 94  ASP A C     1 
ATOM   699  O  O     . ASP A 1 94  ? 146.540 129.654 180.920 1.00 180.97 ? 94  ASP A O     1 
ATOM   700  C  CB    . ASP A 1 94  ? 144.920 132.510 180.586 1.00 180.97 ? 94  ASP A CB    1 
ATOM   701  C  CG    . ASP A 1 94  ? 146.166 132.971 181.317 1.00 180.97 ? 94  ASP A CG    1 
ATOM   702  O  OD1   . ASP A 1 94  ? 147.279 132.615 180.876 1.00 180.97 ? 94  ASP A OD1   1 
ATOM   703  O  OD2   . ASP A 1 94  ? 146.033 133.687 182.331 1.00 180.97 ? 94  ASP A OD2   1 
ATOM   704  N  N     . MET A 1 95  ? 144.323 129.467 181.232 1.00 172.99 ? 95  MET A N     1 
ATOM   705  C  CA    . MET A 1 95  ? 144.469 128.386 182.201 1.00 172.99 ? 95  MET A CA    1 
ATOM   706  C  C     . MET A 1 95  ? 144.762 127.033 181.562 1.00 172.99 ? 95  MET A C     1 
ATOM   707  O  O     . MET A 1 95  ? 144.717 126.019 182.266 1.00 172.99 ? 95  MET A O     1 
ATOM   708  C  CB    . MET A 1 95  ? 143.220 128.272 183.082 1.00 172.99 ? 95  MET A CB    1 
ATOM   709  C  CG    . MET A 1 95  ? 141.934 127.961 182.340 1.00 172.99 ? 95  MET A CG    1 
ATOM   710  S  SD    . MET A 1 95  ? 140.571 128.998 182.904 1.00 172.99 ? 95  MET A SD    1 
ATOM   711  C  CE    . MET A 1 95  ? 140.938 130.538 182.079 1.00 172.99 ? 95  MET A CE    1 
ATOM   712  N  N     . GLY A 1 96  ? 145.062 126.987 180.266 1.00 163.51 ? 96  GLY A N     1 
ATOM   713  C  CA    . GLY A 1 96  ? 145.440 125.741 179.627 1.00 163.51 ? 96  GLY A CA    1 
ATOM   714  C  C     . GLY A 1 96  ? 144.353 124.687 179.647 1.00 163.51 ? 96  GLY A C     1 
ATOM   715  O  O     . GLY A 1 96  ? 144.604 123.529 179.993 1.00 163.51 ? 96  GLY A O     1 
ATOM   716  N  N     . VAL A 1 97  ? 143.132 125.083 179.279 1.00 156.82 ? 97  VAL A N     1 
ATOM   717  C  CA    . VAL A 1 97  ? 141.998 124.167 179.313 1.00 156.82 ? 97  VAL A CA    1 
ATOM   718  C  C     . VAL A 1 97  ? 142.154 123.025 178.314 1.00 156.82 ? 97  VAL A C     1 
ATOM   719  O  O     . VAL A 1 97  ? 141.417 122.036 178.391 1.00 156.82 ? 97  VAL A O     1 
ATOM   720  C  CB    . VAL A 1 97  ? 140.693 124.944 179.058 1.00 156.82 ? 97  VAL A CB    1 
ATOM   721  C  CG1   . VAL A 1 97  ? 140.452 125.117 177.564 1.00 156.82 ? 97  VAL A CG1   1 
ATOM   722  C  CG2   . VAL A 1 97  ? 139.519 124.257 179.728 1.00 156.82 ? 97  VAL A CG2   1 
ATOM   723  N  N     . ASP A 1 98  ? 143.099 123.136 177.377 1.00 183.72 ? 98  ASP A N     1 
ATOM   724  C  CA    . ASP A 1 98  ? 143.262 122.109 176.352 1.00 183.72 ? 98  ASP A CA    1 
ATOM   725  C  C     . ASP A 1 98  ? 143.744 120.790 176.945 1.00 183.72 ? 98  ASP A C     1 
ATOM   726  O  O     . ASP A 1 98  ? 143.371 119.713 176.463 1.00 183.72 ? 98  ASP A O     1 
ATOM   727  C  CB    . ASP A 1 98  ? 144.234 122.596 175.279 1.00 183.72 ? 98  ASP A CB    1 
ATOM   728  C  CG    . ASP A 1 98  ? 145.505 123.176 175.868 1.00 183.72 ? 98  ASP A CG    1 
ATOM   729  O  OD1   . ASP A 1 98  ? 145.564 123.345 177.103 1.00 183.72 ? 98  ASP A OD1   1 
ATOM   730  O  OD2   . ASP A 1 98  ? 146.444 123.461 175.095 1.00 183.72 ? 98  ASP A OD2   1 
ATOM   731  N  N     . SER A 1 99  ? 144.570 120.847 177.987 1.00 161.55 ? 99  SER A N     1 
ATOM   732  C  CA    . SER A 1 99  ? 145.190 119.657 178.557 1.00 161.55 ? 99  SER A CA    1 
ATOM   733  C  C     . SER A 1 99  ? 144.245 118.843 179.434 1.00 161.55 ? 99  SER A C     1 
ATOM   734  O  O     . SER A 1 99  ? 144.711 117.961 180.164 1.00 161.55 ? 99  SER A O     1 
ATOM   735  C  CB    . SER A 1 99  ? 146.430 120.052 179.363 1.00 161.55 ? 99  SER A CB    1 
ATOM   736  O  OG    . SER A 1 99  ? 146.085 120.901 180.444 1.00 161.55 ? 99  SER A OG    1 
ATOM   737  N  N     . TRP A 1 100 ? 142.944 119.109 179.388 1.00 149.43 ? 100 TRP A N     1 
ATOM   738  C  CA    . TRP A 1 100 ? 141.984 118.388 180.209 1.00 149.43 ? 100 TRP A CA    1 
ATOM   739  C  C     . TRP A 1 100 ? 141.519 117.112 179.510 1.00 149.43 ? 100 TRP A C     1 
ATOM   740  O  O     . TRP A 1 100 ? 141.769 116.895 178.323 1.00 149.43 ? 100 TRP A O     1 
ATOM   741  C  CB    . TRP A 1 100 ? 140.775 119.266 180.537 1.00 149.43 ? 100 TRP A CB    1 
ATOM   742  C  CG    . TRP A 1 100 ? 141.098 120.517 181.298 1.00 149.43 ? 100 TRP A CG    1 
ATOM   743  C  CD1   . TRP A 1 100 ? 142.336 120.995 181.615 1.00 149.43 ? 100 TRP A CD1   1 
ATOM   744  C  CD2   . TRP A 1 100 ? 140.157 121.438 181.862 1.00 149.43 ? 100 TRP A CD2   1 
ATOM   745  N  NE1   . TRP A 1 100 ? 142.224 122.164 182.328 1.00 149.43 ? 100 TRP A NE1   1 
ATOM   746  C  CE2   . TRP A 1 100 ? 140.896 122.455 182.494 1.00 149.43 ? 100 TRP A CE2   1 
ATOM   747  C  CE3   . TRP A 1 100 ? 138.761 121.502 181.888 1.00 149.43 ? 100 TRP A CE3   1 
ATOM   748  C  CZ2   . TRP A 1 100 ? 140.287 123.525 183.145 1.00 149.43 ? 100 TRP A CZ2   1 
ATOM   749  C  CZ3   . TRP A 1 100 ? 138.157 122.563 182.534 1.00 149.43 ? 100 TRP A CZ3   1 
ATOM   750  C  CH2   . TRP A 1 100 ? 138.919 123.561 183.154 1.00 149.43 ? 100 TRP A CH2   1 
ATOM   751  N  N     . ASN A 1 101 ? 140.833 116.266 180.273 1.00 158.96 ? 101 ASN A N     1 
ATOM   752  C  CA    . ASN A 1 101 ? 140.278 115.014 179.781 1.00 158.96 ? 101 ASN A CA    1 
ATOM   753  C  C     . ASN A 1 101 ? 138.752 115.057 179.847 1.00 158.96 ? 101 ASN A C     1 
ATOM   754  O  O     . ASN A 1 101 ? 138.150 116.048 180.269 1.00 158.96 ? 101 ASN A O     1 
ATOM   755  C  CB    . ASN A 1 101 ? 140.839 113.831 180.573 1.00 158.96 ? 101 ASN A CB    1 
ATOM   756  C  CG    . ASN A 1 101 ? 140.882 114.097 182.063 1.00 158.96 ? 101 ASN A CG    1 
ATOM   757  O  OD1   . ASN A 1 101 ? 140.015 114.777 182.611 1.00 158.96 ? 101 ASN A OD1   1 
ATOM   758  N  ND2   . ASN A 1 101 ? 141.898 113.561 182.728 1.00 158.96 ? 101 ASN A ND2   1 
ATOM   759  N  N     . LYS A 1 102 ? 138.131 113.950 179.433 1.00 153.58 ? 102 LYS A N     1 
ATOM   760  C  CA    . LYS A 1 102 ? 136.680 113.922 179.254 1.00 153.58 ? 102 LYS A CA    1 
ATOM   761  C  C     . LYS A 1 102 ? 135.938 114.150 180.566 1.00 153.58 ? 102 LYS A C     1 
ATOM   762  O  O     . LYS A 1 102 ? 134.937 114.877 180.602 1.00 153.58 ? 102 LYS A O     1 
ATOM   763  C  CB    . LYS A 1 102 ? 136.262 112.591 178.632 1.00 153.58 ? 102 LYS A CB    1 
ATOM   764  C  CG    . LYS A 1 102 ? 135.064 112.687 177.709 1.00 153.58 ? 102 LYS A CG    1 
ATOM   765  C  CD    . LYS A 1 102 ? 135.498 112.937 176.275 1.00 153.58 ? 102 LYS A CD    1 
ATOM   766  C  CE    . LYS A 1 102 ? 134.335 112.780 175.310 1.00 153.58 ? 102 LYS A CE    1 
ATOM   767  N  NZ    . LYS A 1 102 ? 134.785 112.790 173.891 1.00 153.58 ? 102 LYS A NZ    1 
ATOM   768  N  N     . GLU A 1 103 ? 136.405 113.529 181.650 1.00 159.15 ? 103 GLU A N     1 
ATOM   769  C  CA    . GLU A 1 103 ? 135.681 113.600 182.916 1.00 159.15 ? 103 GLU A CA    1 
ATOM   770  C  C     . GLU A 1 103 ? 135.616 115.027 183.448 1.00 159.15 ? 103 GLU A C     1 
ATOM   771  O  O     . GLU A 1 103 ? 134.573 115.461 183.953 1.00 159.15 ? 103 GLU A O     1 
ATOM   772  C  CB    . GLU A 1 103 ? 136.329 112.669 183.944 1.00 159.15 ? 103 GLU A CB    1 
ATOM   773  C  CG    . GLU A 1 103 ? 137.843 112.793 184.043 1.00 159.15 ? 103 GLU A CG    1 
ATOM   774  C  CD    . GLU A 1 103 ? 138.572 111.921 183.037 1.00 159.15 ? 103 GLU A CD    1 
ATOM   775  O  OE1   . GLU A 1 103 ? 138.356 112.107 181.821 1.00 159.15 ? 103 GLU A OE1   1 
ATOM   776  O  OE2   . GLU A 1 103 ? 139.361 111.052 183.463 1.00 159.15 ? 103 GLU A OE2   1 
ATOM   777  N  N     . LYS A 1 104 ? 136.721 115.770 183.352 1.00 154.10 ? 104 LYS A N     1 
ATOM   778  C  CA    . LYS A 1 104 ? 136.721 117.146 183.835 1.00 154.10 ? 104 LYS A CA    1 
ATOM   779  C  C     . LYS A 1 104 ? 135.751 118.007 183.038 1.00 154.10 ? 104 LYS A C     1 
ATOM   780  O  O     . LYS A 1 104 ? 135.040 118.843 183.608 1.00 154.10 ? 104 LYS A O     1 
ATOM   781  C  CB    . LYS A 1 104 ? 138.134 117.727 183.778 1.00 154.10 ? 104 LYS A CB    1 
ATOM   782  C  CG    . LYS A 1 104 ? 138.288 119.030 184.546 1.00 154.10 ? 104 LYS A CG    1 
ATOM   783  C  CD    . LYS A 1 104 ? 139.628 119.106 185.257 1.00 154.10 ? 104 LYS A CD    1 
ATOM   784  C  CE    . LYS A 1 104 ? 140.784 118.941 184.287 1.00 154.10 ? 104 LYS A CE    1 
ATOM   785  N  NZ    . LYS A 1 104 ? 142.009 118.439 184.966 1.00 154.10 ? 104 LYS A NZ    1 
ATOM   786  N  N     . TRP A 1 105 ? 135.707 117.819 181.718 1.00 135.11 ? 105 TRP A N     1 
ATOM   787  C  CA    . TRP A 1 105 ? 134.747 118.557 180.905 1.00 135.11 ? 105 TRP A CA    1 
ATOM   788  C  C     . TRP A 1 105 ? 133.318 118.187 181.272 1.00 135.11 ? 105 TRP A C     1 
ATOM   789  O  O     . TRP A 1 105 ? 132.433 119.051 181.300 1.00 135.11 ? 105 TRP A O     1 
ATOM   790  C  CB    . TRP A 1 105 ? 135.007 118.306 179.421 1.00 135.11 ? 105 TRP A CB    1 
ATOM   791  C  CG    . TRP A 1 105 ? 136.214 119.015 178.915 1.00 135.11 ? 105 TRP A CG    1 
ATOM   792  C  CD1   . TRP A 1 105 ? 137.468 118.505 178.779 1.00 135.11 ? 105 TRP A CD1   1 
ATOM   793  C  CD2   . TRP A 1 105 ? 136.291 120.384 178.506 1.00 135.11 ? 105 TRP A CD2   1 
ATOM   794  N  NE1   . TRP A 1 105 ? 138.321 119.463 178.292 1.00 135.11 ? 105 TRP A NE1   1 
ATOM   795  C  CE2   . TRP A 1 105 ? 137.623 120.629 178.119 1.00 135.11 ? 105 TRP A CE2   1 
ATOM   796  C  CE3   . TRP A 1 105 ? 135.363 121.425 178.421 1.00 135.11 ? 105 TRP A CE3   1 
ATOM   797  C  CZ2   . TRP A 1 105 ? 138.048 121.869 177.652 1.00 135.11 ? 105 TRP A CZ2   1 
ATOM   798  C  CZ3   . TRP A 1 105 ? 135.787 122.657 177.959 1.00 135.11 ? 105 TRP A CZ3   1 
ATOM   799  C  CH2   . TRP A 1 105 ? 137.117 122.868 177.580 1.00 135.11 ? 105 TRP A CH2   1 
ATOM   800  N  N     . ASN A 1 106 ? 133.071 116.905 181.554 1.00 143.05 ? 106 ASN A N     1 
ATOM   801  C  CA    . ASN A 1 106 ? 131.740 116.498 181.991 1.00 143.05 ? 106 ASN A CA    1 
ATOM   802  C  C     . ASN A 1 106 ? 131.355 117.194 183.288 1.00 143.05 ? 106 ASN A C     1 
ATOM   803  O  O     . ASN A 1 106 ? 130.227 117.679 183.431 1.00 143.05 ? 106 ASN A O     1 
ATOM   804  C  CB    . ASN A 1 106 ? 131.683 114.981 182.160 1.00 143.05 ? 106 ASN A CB    1 
ATOM   805  C  CG    . ASN A 1 106 ? 131.593 114.251 180.837 1.00 143.05 ? 106 ASN A CG    1 
ATOM   806  O  OD1   . ASN A 1 106 ? 130.925 114.706 179.908 1.00 143.05 ? 106 ASN A OD1   1 
ATOM   807  N  ND2   . ASN A 1 106 ? 132.267 113.110 180.743 1.00 143.05 ? 106 ASN A ND2   1 
ATOM   808  N  N     . GLN A 1 107 ? 132.285 117.263 184.243 1.00 157.77 ? 107 GLN A N     1 
ATOM   809  C  CA    . GLN A 1 107 ? 131.996 117.950 185.499 1.00 157.77 ? 107 GLN A CA    1 
ATOM   810  C  C     . GLN A 1 107 ? 131.722 119.432 185.271 1.00 157.77 ? 107 GLN A C     1 
ATOM   811  O  O     . GLN A 1 107 ? 130.764 119.986 185.824 1.00 157.77 ? 107 GLN A O     1 
ATOM   812  C  CB    . GLN A 1 107 ? 133.148 117.768 186.488 1.00 157.77 ? 107 GLN A CB    1 
ATOM   813  C  CG    . GLN A 1 107 ? 133.554 116.324 186.727 1.00 157.77 ? 107 GLN A CG    1 
ATOM   814  C  CD    . GLN A 1 107 ? 132.375 115.370 186.708 1.00 157.77 ? 107 GLN A CD    1 
ATOM   815  O  OE1   . GLN A 1 107 ? 131.446 115.495 187.508 1.00 157.77 ? 107 GLN A OE1   1 
ATOM   816  N  NE2   . GLN A 1 107 ? 132.405 114.414 185.788 1.00 157.77 ? 107 GLN A NE2   1 
ATOM   817  N  N     . GLU A 1 108 ? 132.548 120.085 184.448 1.00 152.61 ? 108 GLU A N     1 
ATOM   818  C  CA    . GLU A 1 108 ? 132.353 121.508 184.186 1.00 152.61 ? 108 GLU A CA    1 
ATOM   819  C  C     . GLU A 1 108 ? 131.004 121.767 183.531 1.00 152.61 ? 108 GLU A C     1 
ATOM   820  O  O     . GLU A 1 108 ? 130.306 122.723 183.887 1.00 152.61 ? 108 GLU A O     1 
ATOM   821  C  CB    . GLU A 1 108 ? 133.484 122.047 183.311 1.00 152.61 ? 108 GLU A CB    1 
ATOM   822  C  CG    . GLU A 1 108 ? 134.855 121.958 183.951 1.00 152.61 ? 108 GLU A CG    1 
ATOM   823  C  CD    . GLU A 1 108 ? 134.894 122.583 185.329 1.00 152.61 ? 108 GLU A CD    1 
ATOM   824  O  OE1   . GLU A 1 108 ? 134.989 123.825 185.416 1.00 152.61 ? 108 GLU A OE1   1 
ATOM   825  O  OE2   . GLU A 1 108 ? 134.829 121.833 186.325 1.00 152.61 ? 108 GLU A OE2   1 
ATOM   826  N  N     . PHE A 1 109 ? 130.618 120.924 182.573 1.00 140.16 ? 109 PHE A N     1 
ATOM   827  C  CA    . PHE A 1 109 ? 129.313 121.076 181.940 1.00 140.16 ? 109 PHE A CA    1 
ATOM   828  C  C     . PHE A 1 109 ? 128.181 120.827 182.927 1.00 140.16 ? 109 PHE A C     1 
ATOM   829  O  O     . PHE A 1 109 ? 127.147 121.499 182.862 1.00 140.16 ? 109 PHE A O     1 
ATOM   830  C  CB    . PHE A 1 109 ? 129.194 120.134 180.743 1.00 140.16 ? 109 PHE A CB    1 
ATOM   831  C  CG    . PHE A 1 109 ? 129.905 120.623 179.511 1.00 140.16 ? 109 PHE A CG    1 
ATOM   832  C  CD1   . PHE A 1 109 ? 131.038 121.411 179.611 1.00 140.16 ? 109 PHE A CD1   1 
ATOM   833  C  CD2   . PHE A 1 109 ? 129.434 120.297 178.252 1.00 140.16 ? 109 PHE A CD2   1 
ATOM   834  C  CE1   . PHE A 1 109 ? 131.688 121.859 178.481 1.00 140.16 ? 109 PHE A CE1   1 
ATOM   835  C  CE2   . PHE A 1 109 ? 130.081 120.745 177.119 1.00 140.16 ? 109 PHE A CE2   1 
ATOM   836  C  CZ    . PHE A 1 109 ? 131.209 121.526 177.233 1.00 140.16 ? 109 PHE A CZ    1 
ATOM   837  N  N     . GLU A 1 110 ? 128.355 119.868 183.839 1.00 151.41 ? 110 GLU A N     1 
ATOM   838  C  CA    . GLU A 1 110 ? 127.328 119.614 184.841 1.00 151.41 ? 110 GLU A CA    1 
ATOM   839  C  C     . GLU A 1 110 ? 127.143 120.813 185.761 1.00 151.41 ? 110 GLU A C     1 
ATOM   840  O  O     . GLU A 1 110 ? 126.011 121.160 186.120 1.00 151.41 ? 110 GLU A O     1 
ATOM   841  C  CB    . GLU A 1 110 ? 127.685 118.367 185.652 1.00 151.41 ? 110 GLU A CB    1 
ATOM   842  C  CG    . GLU A 1 110 ? 126.591 117.913 186.604 1.00 151.41 ? 110 GLU A CG    1 
ATOM   843  C  CD    . GLU A 1 110 ? 125.402 117.305 185.884 1.00 151.41 ? 110 GLU A CD    1 
ATOM   844  O  OE1   . GLU A 1 110 ? 125.537 116.956 184.692 1.00 151.41 ? 110 GLU A OE1   1 
ATOM   845  O  OE2   . GLU A 1 110 ? 124.331 117.175 186.510 1.00 151.41 ? 110 GLU A OE2   1 
ATOM   846  N  N     . LYS A 1 111 ? 128.242 121.460 186.158 1.00 156.63 ? 111 LYS A N     1 
ATOM   847  C  CA    . LYS A 1 111 ? 128.140 122.578 187.093 1.00 156.63 ? 111 LYS A CA    1 
ATOM   848  C  C     . LYS A 1 111 ? 127.413 123.767 186.471 1.00 156.63 ? 111 LYS A C     1 
ATOM   849  O  O     . LYS A 1 111 ? 126.472 124.309 187.062 1.00 156.63 ? 111 LYS A O     1 
ATOM   850  C  CB    . LYS A 1 111 ? 129.529 122.995 187.575 1.00 156.63 ? 111 LYS A CB    1 
ATOM   851  C  CG    . LYS A 1 111 ? 130.329 121.881 188.224 1.00 156.63 ? 111 LYS A CG    1 
ATOM   852  C  CD    . LYS A 1 111 ? 129.728 121.479 189.559 1.00 156.63 ? 111 LYS A CD    1 
ATOM   853  C  CE    . LYS A 1 111 ? 129.766 122.628 190.553 1.00 156.63 ? 111 LYS A CE    1 
ATOM   854  N  NZ    . LYS A 1 111 ? 131.036 123.404 190.467 1.00 156.63 ? 111 LYS A NZ    1 
ATOM   855  N  N     . HIS A 1 112 ? 127.829 124.184 185.280 1.00 139.16 ? 112 HIS A N     1 
ATOM   856  C  CA    . HIS A 1 112 ? 127.338 125.421 184.688 1.00 139.16 ? 112 HIS A CA    1 
ATOM   857  C  C     . HIS A 1 112 ? 126.127 125.173 183.798 1.00 139.16 ? 112 HIS A C     1 
ATOM   858  O  O     . HIS A 1 112 ? 125.986 124.103 183.199 1.00 139.16 ? 112 HIS A O     1 
ATOM   859  C  CB    . HIS A 1 112 ? 128.438 126.106 183.877 1.00 139.16 ? 112 HIS A CB    1 
ATOM   860  C  CG    . HIS A 1 112 ? 129.707 126.322 184.640 1.00 139.16 ? 112 HIS A CG    1 
ATOM   861  N  ND1   . HIS A 1 112 ? 129.842 127.306 185.595 1.00 139.16 ? 112 HIS A ND1   1 
ATOM   862  C  CD2   . HIS A 1 112 ? 130.901 125.686 184.584 1.00 139.16 ? 112 HIS A CD2   1 
ATOM   863  C  CE1   . HIS A 1 112 ? 131.063 127.266 186.097 1.00 139.16 ? 112 HIS A CE1   1 
ATOM   864  N  NE2   . HIS A 1 112 ? 131.726 126.291 185.501 1.00 139.16 ? 112 HIS A NE2   1 
ATOM   865  N  N     . GLN A 1 113 ? 125.252 126.177 183.722 1.00 166.05 ? 113 GLN A N     1 
ATOM   866  C  CA    . GLN A 1 113 ? 124.105 126.157 182.821 1.00 166.05 ? 113 GLN A CA    1 
ATOM   867  C  C     . GLN A 1 113 ? 124.359 126.963 181.553 1.00 166.05 ? 113 GLN A C     1 
ATOM   868  O  O     . GLN A 1 113 ? 123.930 126.561 180.467 1.00 166.05 ? 113 GLN A O     1 
ATOM   869  C  CB    . GLN A 1 113 ? 122.863 126.697 183.534 1.00 166.05 ? 113 GLN A CB    1 
ATOM   870  C  CG    . GLN A 1 113 ? 122.187 125.701 184.460 1.00 166.05 ? 113 GLN A CG    1 
ATOM   871  C  CD    . GLN A 1 113 ? 122.365 126.054 185.923 1.00 166.05 ? 113 GLN A CD    1 
ATOM   872  O  OE1   . GLN A 1 113 ? 123.398 126.590 186.320 1.00 166.05 ? 113 GLN A OE1   1 
ATOM   873  N  NE2   . GLN A 1 113 ? 121.355 125.757 186.731 1.00 166.05 ? 113 GLN A NE2   1 
ATOM   874  N  N     . VAL A 1 114 ? 125.044 128.096 181.675 1.00 147.87 ? 114 VAL A N     1 
ATOM   875  C  CA    . VAL A 1 114 ? 125.382 128.957 180.547 1.00 147.87 ? 114 VAL A CA    1 
ATOM   876  C  C     . VAL A 1 114 ? 126.896 129.094 180.497 1.00 147.87 ? 114 VAL A C     1 
ATOM   877  O  O     . VAL A 1 114 ? 127.537 129.325 181.529 1.00 147.87 ? 114 VAL A O     1 
ATOM   878  C  CB    . VAL A 1 114 ? 124.711 130.338 180.665 1.00 147.87 ? 114 VAL A CB    1 
ATOM   879  C  CG1   . VAL A 1 114 ? 125.158 131.247 179.534 1.00 147.87 ? 114 VAL A CG1   1 
ATOM   880  C  CG2   . VAL A 1 114 ? 123.202 130.190 180.673 1.00 147.87 ? 114 VAL A CG2   1 
ATOM   881  N  N     . LEU A 1 115 ? 127.468 128.937 179.307 1.00 112.40 ? 115 LEU A N     1 
ATOM   882  C  CA    . LEU A 1 115 ? 128.911 128.989 179.126 1.00 112.40 ? 115 LEU A CA    1 
ATOM   883  C  C     . LEU A 1 115 ? 129.269 130.058 178.105 1.00 112.40 ? 115 LEU A C     1 
ATOM   884  O  O     . LEU A 1 115 ? 128.599 130.198 177.078 1.00 112.40 ? 115 LEU A O     1 
ATOM   885  C  CB    . LEU A 1 115 ? 129.457 127.632 178.671 1.00 112.40 ? 115 LEU A CB    1 
ATOM   886  C  CG    . LEU A 1 115 ? 129.684 126.575 179.753 1.00 112.40 ? 115 LEU A CG    1 
ATOM   887  C  CD1   . LEU A 1 115 ? 128.373 125.930 180.172 1.00 112.40 ? 115 LEU A CD1   1 
ATOM   888  C  CD2   . LEU A 1 115 ? 130.670 125.527 179.270 1.00 112.40 ? 115 LEU A CD2   1 
ATOM   889  N  N     . VAL A 1 116 ? 130.326 130.813 178.394 1.00 125.19 ? 116 VAL A N     1 
ATOM   890  C  CA    . VAL A 1 116 ? 130.869 131.796 177.465 1.00 125.19 ? 116 VAL A CA    1 
ATOM   891  C  C     . VAL A 1 116 ? 132.358 131.526 177.279 1.00 125.19 ? 116 VAL A C     1 
ATOM   892  O  O     . VAL A 1 116 ? 133.101 131.352 178.252 1.00 125.19 ? 116 VAL A O     1 
ATOM   893  C  CB    . VAL A 1 116 ? 130.588 133.248 177.928 1.00 125.19 ? 116 VAL A CB    1 
ATOM   894  C  CG1   . VAL A 1 116 ? 131.634 133.764 178.908 1.00 125.19 ? 116 VAL A CG1   1 
ATOM   895  C  CG2   . VAL A 1 116 ? 130.492 134.173 176.727 1.00 125.19 ? 116 VAL A CG2   1 
ATOM   896  N  N     . MET A 1 117 ? 132.777 131.433 176.020 1.00 128.56 ? 117 MET A N     1 
ATOM   897  C  CA    . MET A 1 117 ? 134.156 131.145 175.634 1.00 128.56 ? 117 MET A CA    1 
ATOM   898  C  C     . MET A 1 117 ? 134.379 131.752 174.255 1.00 128.56 ? 117 MET A C     1 
ATOM   899  O  O     . MET A 1 117 ? 133.431 132.144 173.568 1.00 128.56 ? 117 MET A O     1 
ATOM   900  C  CB    . MET A 1 117 ? 134.462 129.644 175.611 1.00 128.56 ? 117 MET A CB    1 
ATOM   901  C  CG    . MET A 1 117 ? 134.356 128.916 176.942 1.00 128.56 ? 117 MET A CG    1 
ATOM   902  S  SD    . MET A 1 117 ? 134.030 127.155 176.747 1.00 128.56 ? 117 MET A SD    1 
ATOM   903  C  CE    . MET A 1 117 ? 133.094 127.153 175.219 1.00 128.56 ? 117 MET A CE    1 
ATOM   904  N  N     . THR A 1 118 ? 135.644 131.824 173.853 1.00 115.46 ? 118 THR A N     1 
ATOM   905  C  CA    . THR A 1 118 ? 135.972 132.280 172.512 1.00 115.46 ? 118 THR A CA    1 
ATOM   906  C  C     . THR A 1 118 ? 135.632 131.198 171.487 1.00 115.46 ? 118 THR A C     1 
ATOM   907  O  O     . THR A 1 118 ? 135.176 130.102 171.823 1.00 115.46 ? 118 THR A O     1 
ATOM   908  C  CB    . THR A 1 118 ? 137.448 132.660 172.418 1.00 115.46 ? 118 THR A CB    1 
ATOM   909  O  OG1   . THR A 1 118 ? 137.719 133.196 171.118 1.00 115.46 ? 118 THR A OG1   1 
ATOM   910  C  CG2   . THR A 1 118 ? 138.322 131.444 172.653 1.00 115.46 ? 118 THR A CG2   1 
ATOM   911  N  N     . ALA A 1 119 ? 135.861 131.521 170.215 1.00 109.28 ? 119 ALA A N     1 
ATOM   912  C  CA    . ALA A 1 119 ? 135.490 130.607 169.138 1.00 109.28 ? 119 ALA A CA    1 
ATOM   913  C  C     . ALA A 1 119 ? 136.443 129.421 169.035 1.00 109.28 ? 119 ALA A C     1 
ATOM   914  O  O     . ALA A 1 119 ? 136.003 128.289 168.795 1.00 109.28 ? 119 ALA A O     1 
ATOM   915  C  CB    . ALA A 1 119 ? 135.437 131.359 167.810 1.00 109.28 ? 119 ALA A CB    1 
ATOM   916  N  N     . GLN A 1 120 ? 137.746 129.660 169.199 1.00 112.03 ? 120 GLN A N     1 
ATOM   917  C  CA    . GLN A 1 120 ? 138.726 128.603 168.968 1.00 112.03 ? 120 GLN A CA    1 
ATOM   918  C  C     . GLN A 1 120 ? 138.576 127.468 169.974 1.00 112.03 ? 120 GLN A C     1 
ATOM   919  O  O     . GLN A 1 120 ? 138.684 126.293 169.608 1.00 112.03 ? 120 GLN A O     1 
ATOM   920  C  CB    . GLN A 1 120 ? 140.140 129.180 169.013 1.00 112.03 ? 120 GLN A CB    1 
ATOM   921  C  CG    . GLN A 1 120 ? 141.234 128.133 168.935 1.00 112.03 ? 120 GLN A CG    1 
ATOM   922  C  CD    . GLN A 1 120 ? 142.272 128.459 167.879 1.00 112.03 ? 120 GLN A CD    1 
ATOM   923  O  OE1   . GLN A 1 120 ? 142.022 129.256 166.974 1.00 112.03 ? 120 GLN A OE1   1 
ATOM   924  N  NE2   . GLN A 1 120 ? 143.439 127.836 167.983 1.00 112.03 ? 120 GLN A NE2   1 
ATOM   925  N  N     . ILE A 1 121 ? 138.333 127.796 171.245 1.00 114.17 ? 121 ILE A N     1 
ATOM   926  C  CA    . ILE A 1 121 ? 138.154 126.756 172.254 1.00 114.17 ? 121 ILE A CA    1 
ATOM   927  C  C     . ILE A 1 121 ? 136.906 125.934 171.953 1.00 114.17 ? 121 ILE A C     1 
ATOM   928  O  O     . ILE A 1 121 ? 136.899 124.706 172.103 1.00 114.17 ? 121 ILE A O     1 
ATOM   929  C  CB    . ILE A 1 121 ? 138.102 127.378 173.660 1.00 114.17 ? 121 ILE A CB    1 
ATOM   930  C  CG1   . ILE A 1 121 ? 139.402 128.124 173.958 1.00 114.17 ? 121 ILE A CG1   1 
ATOM   931  C  CG2   . ILE A 1 121 ? 137.864 126.309 174.708 1.00 114.17 ? 121 ILE A CG2   1 
ATOM   932  C  CD1   . ILE A 1 121 ? 139.339 128.986 175.199 1.00 114.17 ? 121 ILE A CD1   1 
ATOM   933  N  N     . PHE A 1 122 ? 135.831 126.601 171.527 1.00 122.73 ? 122 PHE A N     1 
ATOM   934  C  CA    . PHE A 1 122 ? 134.612 125.894 171.153 1.00 122.73 ? 122 PHE A CA    1 
ATOM   935  C  C     . PHE A 1 122 ? 134.871 124.935 169.998 1.00 122.73 ? 122 PHE A C     1 
ATOM   936  O  O     . PHE A 1 122 ? 134.417 123.784 170.014 1.00 122.73 ? 122 PHE A O     1 
ATOM   937  C  CB    . PHE A 1 122 ? 133.522 126.900 170.783 1.00 122.73 ? 122 PHE A CB    1 
ATOM   938  C  CG    . PHE A 1 122 ? 132.162 126.291 170.620 1.00 122.73 ? 122 PHE A CG    1 
ATOM   939  C  CD1   . PHE A 1 122 ? 131.524 125.688 171.689 1.00 122.73 ? 122 PHE A CD1   1 
ATOM   940  C  CD2   . PHE A 1 122 ? 131.520 126.322 169.393 1.00 122.73 ? 122 PHE A CD2   1 
ATOM   941  C  CE1   . PHE A 1 122 ? 130.270 125.128 171.539 1.00 122.73 ? 122 PHE A CE1   1 
ATOM   942  C  CE2   . PHE A 1 122 ? 130.267 125.763 169.238 1.00 122.73 ? 122 PHE A CE2   1 
ATOM   943  C  CZ    . PHE A 1 122 ? 129.642 125.166 170.311 1.00 122.73 ? 122 PHE A CZ    1 
ATOM   944  N  N     . LEU A 1 123 ? 135.607 125.394 168.983 1.00 124.65 ? 123 LEU A N     1 
ATOM   945  C  CA    . LEU A 1 123 ? 135.915 124.531 167.848 1.00 124.65 ? 123 LEU A CA    1 
ATOM   946  C  C     . LEU A 1 123 ? 136.779 123.349 168.270 1.00 124.65 ? 123 LEU A C     1 
ATOM   947  O  O     . LEU A 1 123 ? 136.565 122.219 167.815 1.00 124.65 ? 123 LEU A O     1 
ATOM   948  C  CB    . LEU A 1 123 ? 136.607 125.336 166.749 1.00 124.65 ? 123 LEU A CB    1 
ATOM   949  C  CG    . LEU A 1 123 ? 136.526 124.760 165.335 1.00 124.65 ? 123 LEU A CG    1 
ATOM   950  C  CD1   . LEU A 1 123 ? 135.143 124.198 165.059 1.00 124.65 ? 123 LEU A CD1   1 
ATOM   951  C  CD2   . LEU A 1 123 ? 136.888 125.818 164.310 1.00 124.65 ? 123 LEU A CD2   1 
ATOM   952  N  N     . ASP A 1 124 ? 137.764 123.591 169.139 1.00 121.78 ? 124 ASP A N     1 
ATOM   953  C  CA    . ASP A 1 124 ? 138.622 122.508 169.608 1.00 121.78 ? 124 ASP A CA    1 
ATOM   954  C  C     . ASP A 1 124 ? 137.824 121.470 170.385 1.00 121.78 ? 124 ASP A C     1 
ATOM   955  O  O     . ASP A 1 124 ? 138.048 120.264 170.235 1.00 121.78 ? 124 ASP A O     1 
ATOM   956  C  CB    . ASP A 1 124 ? 139.753 123.067 170.470 1.00 121.78 ? 124 ASP A CB    1 
ATOM   957  C  CG    . ASP A 1 124 ? 141.068 123.157 169.720 1.00 121.78 ? 124 ASP A CG    1 
ATOM   958  O  OD1   . ASP A 1 124 ? 141.049 123.100 168.473 1.00 121.78 ? 124 ASP A OD1   1 
ATOM   959  O  OD2   . ASP A 1 124 ? 142.122 123.287 170.378 1.00 121.78 ? 124 ASP A OD2   1 
ATOM   960  N  N     . ILE A 1 125 ? 136.894 121.921 171.227 1.00 132.36 ? 125 ILE A N     1 
ATOM   961  C  CA    . ILE A 1 125 ? 136.058 120.982 171.969 1.00 132.36 ? 125 ILE A CA    1 
ATOM   962  C  C     . ILE A 1 125 ? 135.163 120.193 171.024 1.00 132.36 ? 125 ILE A C     1 
ATOM   963  O  O     . ILE A 1 125 ? 135.029 118.969 171.152 1.00 132.36 ? 125 ILE A O     1 
ATOM   964  C  CB    . ILE A 1 125 ? 135.241 121.722 173.042 1.00 132.36 ? 125 ILE A CB    1 
ATOM   965  C  CG1   . ILE A 1 125 ? 136.045 121.804 174.333 1.00 132.36 ? 125 ILE A CG1   1 
ATOM   966  C  CG2   . ILE A 1 125 ? 133.906 121.032 173.284 1.00 132.36 ? 125 ILE A CG2   1 
ATOM   967  C  CD1   . ILE A 1 125 ? 136.045 120.506 175.098 1.00 132.36 ? 125 ILE A CD1   1 
ATOM   968  N  N     . LEU A 1 126 ? 134.542 120.870 170.057 1.00 123.72 ? 126 LEU A N     1 
ATOM   969  C  CA    . LEU A 1 126 ? 133.579 120.192 169.196 1.00 123.72 ? 126 LEU A CA    1 
ATOM   970  C  C     . LEU A 1 126 ? 134.266 119.202 168.263 1.00 123.72 ? 126 LEU A C     1 
ATOM   971  O  O     . LEU A 1 126 ? 133.702 118.149 167.944 1.00 123.72 ? 126 LEU A O     1 
ATOM   972  C  CB    . LEU A 1 126 ? 132.778 121.218 168.399 1.00 123.72 ? 126 LEU A CB    1 
ATOM   973  C  CG    . LEU A 1 126 ? 131.408 120.737 167.923 1.00 123.72 ? 126 LEU A CG    1 
ATOM   974  C  CD1   . LEU A 1 126 ? 130.390 121.860 168.013 1.00 123.72 ? 126 LEU A CD1   1 
ATOM   975  C  CD2   . LEU A 1 126 ? 131.483 120.189 166.513 1.00 123.72 ? 126 LEU A CD2   1 
ATOM   976  N  N     . ASN A 1 127 ? 135.483 119.522 167.812 1.00 145.64 ? 127 ASN A N     1 
ATOM   977  C  CA    . ASN A 1 127 ? 136.180 118.644 166.877 1.00 145.64 ? 127 ASN A CA    1 
ATOM   978  C  C     . ASN A 1 127 ? 136.553 117.315 167.522 1.00 145.64 ? 127 ASN A C     1 
ATOM   979  O  O     . ASN A 1 127 ? 136.452 116.261 166.884 1.00 145.64 ? 127 ASN A O     1 
ATOM   980  C  CB    . ASN A 1 127 ? 137.426 119.340 166.334 1.00 145.64 ? 127 ASN A CB    1 
ATOM   981  C  CG    . ASN A 1 127 ? 137.214 119.911 164.949 1.00 145.64 ? 127 ASN A CG    1 
ATOM   982  O  OD1   . ASN A 1 127 ? 136.341 119.463 164.207 1.00 145.64 ? 127 ASN A OD1   1 
ATOM   983  N  ND2   . ASN A 1 127 ? 138.013 120.908 164.591 1.00 145.64 ? 127 ASN A ND2   1 
ATOM   984  N  N     . HIS A 1 128 ? 136.982 117.340 168.780 1.00 138.75 ? 128 HIS A N     1 
ATOM   985  C  CA    . HIS A 1 128 ? 137.425 116.132 169.463 1.00 138.75 ? 128 HIS A CA    1 
ATOM   986  C  C     . HIS A 1 128 ? 136.273 115.265 169.950 1.00 138.75 ? 128 HIS A C     1 
ATOM   987  O  O     . HIS A 1 128 ? 136.512 114.300 170.684 1.00 138.75 ? 128 HIS A O     1 
ATOM   988  C  CB    . HIS A 1 128 ? 138.332 116.499 170.638 1.00 138.75 ? 128 HIS A CB    1 
ATOM   989  C  CG    . HIS A 1 128 ? 139.655 117.063 170.225 1.00 138.75 ? 128 HIS A CG    1 
ATOM   990  N  ND1   . HIS A 1 128 ? 140.399 116.533 169.192 1.00 138.75 ? 128 HIS A ND1   1 
ATOM   991  C  CD2   . HIS A 1 128 ? 140.368 118.109 170.704 1.00 138.75 ? 128 HIS A CD2   1 
ATOM   992  C  CE1   . HIS A 1 128 ? 141.512 117.230 169.052 1.00 138.75 ? 128 HIS A CE1   1 
ATOM   993  N  NE2   . HIS A 1 128 ? 141.518 118.192 169.957 1.00 138.75 ? 128 HIS A NE2   1 
ATOM   994  N  N     . GLY A 1 129 ? 135.037 115.582 169.567 1.00 149.63 ? 129 GLY A N     1 
ATOM   995  C  CA    . GLY A 1 129 ? 133.904 114.757 169.928 1.00 149.63 ? 129 GLY A CA    1 
ATOM   996  C  C     . GLY A 1 129 ? 133.522 114.788 171.387 1.00 149.63 ? 129 GLY A C     1 
ATOM   997  O  O     . GLY A 1 129 ? 132.836 113.872 171.851 1.00 149.63 ? 129 GLY A O     1 
ATOM   998  N  N     . PHE A 1 130 ? 133.943 115.810 172.131 1.00 146.69 ? 130 PHE A N     1 
ATOM   999  C  CA    . PHE A 1 130 ? 133.608 115.890 173.545 1.00 146.69 ? 130 PHE A CA    1 
ATOM   1000 C  C     . PHE A 1 130 ? 132.172 116.337 173.787 1.00 146.69 ? 130 PHE A C     1 
ATOM   1001 O  O     . PHE A 1 130 ? 131.642 116.106 174.877 1.00 146.69 ? 130 PHE A O     1 
ATOM   1002 C  CB    . PHE A 1 130 ? 134.570 116.836 174.266 1.00 146.69 ? 130 PHE A CB    1 
ATOM   1003 C  CG    . PHE A 1 130 ? 135.912 116.226 174.570 1.00 146.69 ? 130 PHE A CG    1 
ATOM   1004 C  CD1   . PHE A 1 130 ? 136.631 115.565 173.589 1.00 146.69 ? 130 PHE A CD1   1 
ATOM   1005 C  CD2   . PHE A 1 130 ? 136.454 116.317 175.841 1.00 146.69 ? 130 PHE A CD2   1 
ATOM   1006 C  CE1   . PHE A 1 130 ? 137.861 115.006 173.869 1.00 146.69 ? 130 PHE A CE1   1 
ATOM   1007 C  CE2   . PHE A 1 130 ? 137.685 115.761 176.127 1.00 146.69 ? 130 PHE A CE2   1 
ATOM   1008 C  CZ    . PHE A 1 130 ? 138.389 115.105 175.140 1.00 146.69 ? 130 PHE A CZ    1 
ATOM   1009 N  N     . ILE A 1 131 ? 131.535 116.968 172.803 1.00 134.78 ? 131 ILE A N     1 
ATOM   1010 C  CA    . ILE A 1 131 ? 130.153 117.410 172.917 1.00 134.78 ? 131 ILE A CA    1 
ATOM   1011 C  C     . ILE A 1 131 ? 129.412 117.057 171.634 1.00 134.78 ? 131 ILE A C     1 
ATOM   1012 O  O     . ILE A 1 131 ? 130.026 116.894 170.574 1.00 134.78 ? 131 ILE A O     1 
ATOM   1013 C  CB    . ILE A 1 131 ? 130.055 118.923 173.208 1.00 134.78 ? 131 ILE A CB    1 
ATOM   1014 C  CG1   . ILE A 1 131 ? 128.718 119.250 173.870 1.00 134.78 ? 131 ILE A CG1   1 
ATOM   1015 C  CG2   . ILE A 1 131 ? 130.231 119.732 171.934 1.00 134.78 ? 131 ILE A CG2   1 
ATOM   1016 C  CD1   . ILE A 1 131 ? 128.457 118.463 175.129 1.00 134.78 ? 131 ILE A CD1   1 
ATOM   1017 N  N     . SER A 1 132 ? 128.095 116.927 171.740 1.00 137.75 ? 132 SER A N     1 
ATOM   1018 C  CA    . SER A 1 132 ? 127.231 116.673 170.598 1.00 137.75 ? 132 SER A CA    1 
ATOM   1019 C  C     . SER A 1 132 ? 126.397 117.916 170.324 1.00 137.75 ? 132 SER A C     1 
ATOM   1020 O  O     . SER A 1 132 ? 125.893 118.548 171.259 1.00 137.75 ? 132 SER A O     1 
ATOM   1021 C  CB    . SER A 1 132 ? 126.325 115.469 170.850 1.00 137.75 ? 132 SER A CB    1 
ATOM   1022 O  OG    . SER A 1 132 ? 125.361 115.334 169.822 1.00 137.75 ? 132 SER A OG    1 
ATOM   1023 N  N     . LEU A 1 133 ? 126.258 118.264 169.044 1.00 145.39 ? 133 LEU A N     1 
ATOM   1024 C  CA    . LEU A 1 133 ? 125.505 119.457 168.679 1.00 145.39 ? 133 LEU A CA    1 
ATOM   1025 C  C     . LEU A 1 133 ? 124.034 119.353 169.059 1.00 145.39 ? 133 LEU A C     1 
ATOM   1026 O  O     . LEU A 1 133 ? 123.372 120.384 169.217 1.00 145.39 ? 133 LEU A O     1 
ATOM   1027 C  CB    . LEU A 1 133 ? 125.638 119.722 167.180 1.00 145.39 ? 133 LEU A CB    1 
ATOM   1028 C  CG    . LEU A 1 133 ? 125.285 121.134 166.718 1.00 145.39 ? 133 LEU A CG    1 
ATOM   1029 C  CD1   . LEU A 1 133 ? 126.331 122.132 167.188 1.00 145.39 ? 133 LEU A CD1   1 
ATOM   1030 C  CD2   . LEU A 1 133 ? 125.141 121.174 165.213 1.00 145.39 ? 133 LEU A CD2   1 
ATOM   1031 N  N     . SER A 1 134 ? 123.509 118.136 169.216 1.00 119.95 ? 134 SER A N     1 
ATOM   1032 C  CA    . SER A 1 134 ? 122.111 117.976 169.597 1.00 119.95 ? 134 SER A CA    1 
ATOM   1033 C  C     . SER A 1 134 ? 121.837 118.466 171.012 1.00 119.95 ? 134 SER A C     1 
ATOM   1034 O  O     . SER A 1 134 ? 120.671 118.639 171.380 1.00 119.95 ? 134 SER A O     1 
ATOM   1035 C  CB    . SER A 1 134 ? 121.694 116.511 169.467 1.00 119.95 ? 134 SER A CB    1 
ATOM   1036 O  OG    . SER A 1 134 ? 120.357 116.326 169.895 1.00 119.95 ? 134 SER A OG    1 
ATOM   1037 N  N     . GLN A 1 135 ? 122.878 118.686 171.813 1.00 124.06 ? 135 GLN A N     1 
ATOM   1038 C  CA    . GLN A 1 135 ? 122.711 119.177 173.174 1.00 124.06 ? 135 GLN A CA    1 
ATOM   1039 C  C     . GLN A 1 135 ? 122.768 120.695 173.272 1.00 124.06 ? 135 GLN A C     1 
ATOM   1040 O  O     . GLN A 1 135 ? 122.717 121.229 174.386 1.00 124.06 ? 135 GLN A O     1 
ATOM   1041 C  CB    . GLN A 1 135 ? 123.774 118.561 174.086 1.00 124.06 ? 135 GLN A CB    1 
ATOM   1042 C  CG    . GLN A 1 135 ? 123.903 117.057 173.945 1.00 124.06 ? 135 GLN A CG    1 
ATOM   1043 C  CD    . GLN A 1 135 ? 123.995 116.356 175.282 1.00 124.06 ? 135 GLN A CD    1 
ATOM   1044 O  OE1   . GLN A 1 135 ? 123.211 116.623 176.191 1.00 124.06 ? 135 GLN A OE1   1 
ATOM   1045 N  NE2   . GLN A 1 135 ? 124.959 115.453 175.411 1.00 124.06 ? 135 GLN A NE2   1 
ATOM   1046 N  N     . VAL A 1 136 ? 122.882 121.400 172.152 1.00 109.51 ? 136 VAL A N     1 
ATOM   1047 C  CA    . VAL A 1 136 ? 122.934 122.857 172.172 1.00 109.51 ? 136 VAL A CA    1 
ATOM   1048 C  C     . VAL A 1 136 ? 121.516 123.408 172.157 1.00 109.51 ? 136 VAL A C     1 
ATOM   1049 O  O     . VAL A 1 136 ? 120.740 123.139 171.233 1.00 109.51 ? 136 VAL A O     1 
ATOM   1050 C  CB    . VAL A 1 136 ? 123.745 123.388 170.981 1.00 109.51 ? 136 VAL A CB    1 
ATOM   1051 C  CG1   . VAL A 1 136 ? 123.883 124.897 171.070 1.00 109.51 ? 136 VAL A CG1   1 
ATOM   1052 C  CG2   . VAL A 1 136 ? 125.111 122.726 170.933 1.00 109.51 ? 136 VAL A CG2   1 
ATOM   1053 N  N     . ASN A 1 137 ? 121.174 124.184 173.183 1.00 113.63 ? 137 ASN A N     1 
ATOM   1054 C  CA    . ASN A 1 137 ? 119.860 124.809 173.253 1.00 113.63 ? 137 ASN A CA    1 
ATOM   1055 C  C     . ASN A 1 137 ? 119.806 126.099 172.445 1.00 113.63 ? 137 ASN A C     1 
ATOM   1056 O  O     . ASN A 1 137 ? 118.917 126.272 171.606 1.00 113.63 ? 137 ASN A O     1 
ATOM   1057 C  CB    . ASN A 1 137 ? 119.483 125.085 174.711 1.00 113.63 ? 137 ASN A CB    1 
ATOM   1058 C  CG    . ASN A 1 137 ? 118.127 125.745 174.846 1.00 113.63 ? 137 ASN A CG    1 
ATOM   1059 O  OD1   . ASN A 1 137 ? 117.917 126.587 175.716 1.00 113.63 ? 137 ASN A OD1   1 
ATOM   1060 N  ND2   . ASN A 1 137 ? 117.194 125.359 173.984 1.00 113.63 ? 137 ASN A ND2   1 
ATOM   1061 N  N     . LEU A 1 138 ? 120.744 127.012 172.688 1.00 112.78 ? 138 LEU A N     1 
ATOM   1062 C  CA    . LEU A 1 138 ? 120.800 128.265 171.953 1.00 112.78 ? 138 LEU A CA    1 
ATOM   1063 C  C     . LEU A 1 138 ? 122.246 128.721 171.848 1.00 112.78 ? 138 LEU A C     1 
ATOM   1064 O  O     . LEU A 1 138 ? 123.015 128.602 172.805 1.00 112.78 ? 138 LEU A O     1 
ATOM   1065 C  CB    . LEU A 1 138 ? 119.951 129.348 172.625 1.00 112.78 ? 138 LEU A CB    1 
ATOM   1066 C  CG    . LEU A 1 138 ? 119.829 130.656 171.844 1.00 112.78 ? 138 LEU A CG    1 
ATOM   1067 C  CD1   . LEU A 1 138 ? 119.227 130.394 170.480 1.00 112.78 ? 138 LEU A CD1   1 
ATOM   1068 C  CD2   . LEU A 1 138 ? 118.988 131.658 172.608 1.00 112.78 ? 138 LEU A CD2   1 
ATOM   1069 N  N     . LEU A 1 139 ? 122.607 129.244 170.679 1.00 123.40 ? 139 LEU A N     1 
ATOM   1070 C  CA    . LEU A 1 139 ? 123.946 129.751 170.419 1.00 123.40 ? 139 LEU A CA    1 
ATOM   1071 C  C     . LEU A 1 139 ? 123.835 131.175 169.899 1.00 123.40 ? 139 LEU A C     1 
ATOM   1072 O  O     . LEU A 1 139 ? 123.006 131.455 169.028 1.00 123.40 ? 139 LEU A O     1 
ATOM   1073 C  CB    . LEU A 1 139 ? 124.683 128.862 169.413 1.00 123.40 ? 139 LEU A CB    1 
ATOM   1074 C  CG    . LEU A 1 139 ? 126.118 129.254 169.069 1.00 123.40 ? 139 LEU A CG    1 
ATOM   1075 C  CD1   . LEU A 1 139 ? 126.958 129.342 170.326 1.00 123.40 ? 139 LEU A CD1   1 
ATOM   1076 C  CD2   . LEU A 1 139 ? 126.715 128.254 168.097 1.00 123.40 ? 139 LEU A CD2   1 
ATOM   1077 N  N     . ILE A 1 140 ? 124.666 132.068 170.432 1.00 127.93 ? 140 ILE A N     1 
ATOM   1078 C  CA    . ILE A 1 140 ? 124.604 133.493 170.125 1.00 127.93 ? 140 ILE A CA    1 
ATOM   1079 C  C     . ILE A 1 140 ? 125.916 133.910 169.477 1.00 127.93 ? 140 ILE A C     1 
ATOM   1080 O  O     . ILE A 1 140 ? 126.996 133.582 169.981 1.00 127.93 ? 140 ILE A O     1 
ATOM   1081 C  CB    . ILE A 1 140 ? 124.319 134.332 171.384 1.00 127.93 ? 140 ILE A CB    1 
ATOM   1082 C  CG1   . ILE A 1 140 ? 123.159 133.719 172.173 1.00 127.93 ? 140 ILE A CG1   1 
ATOM   1083 C  CG2   . ILE A 1 140 ? 124.019 135.772 171.006 1.00 127.93 ? 140 ILE A CG2   1 
ATOM   1084 C  CD1   . ILE A 1 140 ? 122.535 134.648 173.189 1.00 127.93 ? 140 ILE A CD1   1 
ATOM   1085 N  N     . PHE A 1 141 ? 125.818 134.636 168.365 1.00 145.54 ? 141 PHE A N     1 
ATOM   1086 C  CA    . PHE A 1 141 ? 126.970 135.050 167.570 1.00 145.54 ? 141 PHE A CA    1 
ATOM   1087 C  C     . PHE A 1 141 ? 127.222 136.535 167.795 1.00 145.54 ? 141 PHE A C     1 
ATOM   1088 O  O     . PHE A 1 141 ? 126.426 137.377 167.366 1.00 145.54 ? 141 PHE A O     1 
ATOM   1089 C  CB    . PHE A 1 141 ? 126.735 134.761 166.089 1.00 145.54 ? 141 PHE A CB    1 
ATOM   1090 C  CG    . PHE A 1 141 ? 127.127 133.378 165.674 1.00 145.54 ? 141 PHE A CG    1 
ATOM   1091 C  CD1   . PHE A 1 141 ? 128.092 132.678 166.372 1.00 145.54 ? 141 PHE A CD1   1 
ATOM   1092 C  CD2   . PHE A 1 141 ? 126.526 132.775 164.583 1.00 145.54 ? 141 PHE A CD2   1 
ATOM   1093 C  CE1   . PHE A 1 141 ? 128.455 131.403 165.988 1.00 145.54 ? 141 PHE A CE1   1 
ATOM   1094 C  CE2   . PHE A 1 141 ? 126.884 131.500 164.195 1.00 145.54 ? 141 PHE A CE2   1 
ATOM   1095 C  CZ    . PHE A 1 141 ? 127.849 130.814 164.898 1.00 145.54 ? 141 PHE A CZ    1 
ATOM   1096 N  N     . ASP A 1 142 ? 128.330 136.854 168.456 1.00 155.42 ? 142 ASP A N     1 
ATOM   1097 C  CA    . ASP A 1 142 ? 128.735 138.236 168.673 1.00 155.42 ? 142 ASP A CA    1 
ATOM   1098 C  C     . ASP A 1 142 ? 129.632 138.681 167.525 1.00 155.42 ? 142 ASP A C     1 
ATOM   1099 O  O     . ASP A 1 142 ? 130.559 137.961 167.142 1.00 155.42 ? 142 ASP A O     1 
ATOM   1100 C  CB    . ASP A 1 142 ? 129.463 138.379 170.009 1.00 155.42 ? 142 ASP A CB    1 
ATOM   1101 C  CG    . ASP A 1 142 ? 129.493 139.808 170.508 1.00 155.42 ? 142 ASP A CG    1 
ATOM   1102 O  OD1   . ASP A 1 142 ? 130.378 140.573 170.075 1.00 155.42 ? 142 ASP A OD1   1 
ATOM   1103 O  OD2   . ASP A 1 142 ? 128.632 140.167 171.337 1.00 155.42 ? 142 ASP A OD2   1 
ATOM   1104 N  N     . GLU A 1 143 ? 129.348 139.865 166.977 1.00 163.62 ? 143 GLU A N     1 
ATOM   1105 C  CA    . GLU A 1 143 ? 130.049 140.390 165.805 1.00 163.62 ? 143 GLU A CA    1 
ATOM   1106 C  C     . GLU A 1 143 ? 129.940 139.412 164.632 1.00 163.62 ? 143 GLU A C     1 
ATOM   1107 O  O     . GLU A 1 143 ? 130.931 138.864 164.145 1.00 163.62 ? 143 GLU A O     1 
ATOM   1108 C  CB    . GLU A 1 143 ? 131.515 140.704 166.127 1.00 163.62 ? 143 GLU A CB    1 
ATOM   1109 C  CG    . GLU A 1 143 ? 131.725 141.516 167.391 1.00 163.62 ? 143 GLU A CG    1 
ATOM   1110 C  CD    . GLU A 1 143 ? 131.241 142.944 167.257 1.00 163.62 ? 143 GLU A CD    1 
ATOM   1111 O  OE1   . GLU A 1 143 ? 131.159 143.442 166.116 1.00 163.62 ? 143 GLU A OE1   1 
ATOM   1112 O  OE2   . GLU A 1 143 ? 130.942 143.570 168.295 1.00 163.62 ? 143 GLU A OE2   1 
ATOM   1113 N  N     . CYS A 1 144 ? 128.702 139.206 164.181 1.00 153.91 ? 144 CYS A N     1 
ATOM   1114 C  CA    . CYS A 1 144 ? 128.427 138.205 163.158 1.00 153.91 ? 144 CYS A CA    1 
ATOM   1115 C  C     . CYS A 1 144 ? 128.969 138.579 161.785 1.00 153.91 ? 144 CYS A C     1 
ATOM   1116 O  O     . CYS A 1 144 ? 128.778 137.809 160.839 1.00 153.91 ? 144 CYS A O     1 
ATOM   1117 C  CB    . CYS A 1 144 ? 126.923 137.953 163.057 1.00 153.91 ? 144 CYS A CB    1 
ATOM   1118 S  SG    . CYS A 1 144 ? 125.977 139.343 162.404 1.00 153.91 ? 144 CYS A SG    1 
ATOM   1119 N  N     . HIS A 1 145 ? 129.621 139.733 161.643 1.00 163.14 ? 145 HIS A N     1 
ATOM   1120 C  CA    . HIS A 1 145 ? 130.190 140.112 160.356 1.00 163.14 ? 145 HIS A CA    1 
ATOM   1121 C  C     . HIS A 1 145 ? 131.607 139.592 160.154 1.00 163.14 ? 145 HIS A C     1 
ATOM   1122 O  O     . HIS A 1 145 ? 132.193 139.844 159.095 1.00 163.14 ? 145 HIS A O     1 
ATOM   1123 C  CB    . HIS A 1 145 ? 130.173 141.634 160.194 1.00 163.14 ? 145 HIS A CB    1 
ATOM   1124 C  CG    . HIS A 1 145 ? 130.917 142.367 161.265 1.00 163.14 ? 145 HIS A CG    1 
ATOM   1125 N  ND1   . HIS A 1 145 ? 130.287 142.949 162.343 1.00 163.14 ? 145 HIS A ND1   1 
ATOM   1126 C  CD2   . HIS A 1 145 ? 132.239 142.620 161.420 1.00 163.14 ? 145 HIS A CD2   1 
ATOM   1127 C  CE1   . HIS A 1 145 ? 131.188 143.526 163.118 1.00 163.14 ? 145 HIS A CE1   1 
ATOM   1128 N  NE2   . HIS A 1 145 ? 132.380 143.340 162.581 1.00 163.14 ? 145 HIS A NE2   1 
ATOM   1129 N  N     . HIS A 1 146 ? 132.171 138.883 161.132 1.00 153.71 ? 146 HIS A N     1 
ATOM   1130 C  CA    . HIS A 1 146 ? 133.514 138.332 161.000 1.00 153.71 ? 146 HIS A CA    1 
ATOM   1131 C  C     . HIS A 1 146 ? 133.529 136.916 160.440 1.00 153.71 ? 146 HIS A C     1 
ATOM   1132 O  O     . HIS A 1 146 ? 134.615 136.366 160.225 1.00 153.71 ? 146 HIS A O     1 
ATOM   1133 C  CB    . HIS A 1 146 ? 134.224 138.351 162.354 1.00 153.71 ? 146 HIS A CB    1 
ATOM   1134 C  CG    . HIS A 1 146 ? 134.879 139.657 162.674 1.00 153.71 ? 146 HIS A CG    1 
ATOM   1135 N  ND1   . HIS A 1 146 ? 135.808 140.247 161.845 1.00 153.71 ? 146 HIS A ND1   1 
ATOM   1136 C  CD2   . HIS A 1 146 ? 134.739 140.489 163.734 1.00 153.71 ? 146 HIS A CD2   1 
ATOM   1137 C  CE1   . HIS A 1 146 ? 136.213 141.385 162.380 1.00 153.71 ? 146 HIS A CE1   1 
ATOM   1138 N  NE2   . HIS A 1 146 ? 135.579 141.556 163.526 1.00 153.71 ? 146 HIS A NE2   1 
ATOM   1139 N  N     . ALA A 1 147 ? 132.365 136.317 160.201 1.00 170.00 ? 147 ALA A N     1 
ATOM   1140 C  CA    . ALA A 1 147 ? 132.279 134.945 159.705 1.00 170.00 ? 147 ALA A CA    1 
ATOM   1141 C  C     . ALA A 1 147 ? 132.457 134.961 158.193 1.00 170.00 ? 147 ALA A C     1 
ATOM   1142 O  O     . ALA A 1 147 ? 131.491 134.966 157.429 1.00 170.00 ? 147 ALA A O     1 
ATOM   1143 C  CB    . ALA A 1 147 ? 130.952 134.313 160.102 1.00 170.00 ? 147 ALA A CB    1 
ATOM   1144 N  N     . VAL A 1 148 ? 133.715 134.962 157.753 1.00 151.33 ? 148 VAL A N     1 
ATOM   1145 C  CA    . VAL A 1 148 ? 134.046 135.019 156.334 1.00 151.33 ? 148 VAL A CA    1 
ATOM   1146 C  C     . VAL A 1 148 ? 135.242 134.108 156.084 1.00 151.33 ? 148 VAL A C     1 
ATOM   1147 O  O     . VAL A 1 148 ? 136.114 133.952 156.943 1.00 151.33 ? 148 VAL A O     1 
ATOM   1148 C  CB    . VAL A 1 148 ? 134.334 136.475 155.880 1.00 151.33 ? 148 VAL A CB    1 
ATOM   1149 C  CG1   . VAL A 1 148 ? 134.943 136.515 154.486 1.00 151.33 ? 148 VAL A CG1   1 
ATOM   1150 C  CG2   . VAL A 1 148 ? 133.062 137.310 155.913 1.00 151.33 ? 148 VAL A CG2   1 
ATOM   1151 N  N     . LYS A 1 149 ? 135.265 133.494 154.898 1.00 164.12 ? 149 LYS A N     1 
ATOM   1152 C  CA    . LYS A 1 149 ? 136.391 132.693 154.426 1.00 164.12 ? 149 LYS A CA    1 
ATOM   1153 C  C     . LYS A 1 149 ? 136.677 131.512 155.348 1.00 164.12 ? 149 LYS A C     1 
ATOM   1154 O  O     . LYS A 1 149 ? 135.928 130.531 155.352 1.00 164.12 ? 149 LYS A O     1 
ATOM   1155 C  CB    . LYS A 1 149 ? 137.636 133.574 154.274 1.00 164.12 ? 149 LYS A CB    1 
ATOM   1156 C  CG    . LYS A 1 149 ? 138.762 132.956 153.456 1.00 164.12 ? 149 LYS A CG    1 
ATOM   1157 C  CD    . LYS A 1 149 ? 138.287 132.512 152.086 1.00 164.12 ? 149 LYS A CD    1 
ATOM   1158 C  CE    . LYS A 1 149 ? 139.462 132.108 151.212 1.00 164.12 ? 149 LYS A CE    1 
ATOM   1159 N  NZ    . LYS A 1 149 ? 140.250 131.001 151.820 1.00 164.12 ? 149 LYS A NZ    1 
ATOM   1160 N  N     . ASN A 1 150 ? 137.758 131.589 156.123 1.00 158.41 ? 150 ASN A N     1 
ATOM   1161 C  CA    . ASN A 1 150 ? 138.197 130.485 156.967 1.00 158.41 ? 150 ASN A CA    1 
ATOM   1162 C  C     . ASN A 1 150 ? 138.154 130.845 158.449 1.00 158.41 ? 150 ASN A C     1 
ATOM   1163 O  O     . ASN A 1 150 ? 138.895 130.278 159.255 1.00 158.41 ? 150 ASN A O     1 
ATOM   1164 C  CB    . ASN A 1 150 ? 139.598 130.031 156.566 1.00 158.41 ? 150 ASN A CB    1 
ATOM   1165 C  CG    . ASN A 1 150 ? 139.604 129.238 155.274 1.00 158.41 ? 150 ASN A CG    1 
ATOM   1166 O  OD1   . ASN A 1 150 ? 138.612 129.209 154.547 1.00 158.41 ? 150 ASN A OD1   1 
ATOM   1167 N  ND2   . ASN A 1 150 ? 140.725 128.589 154.983 1.00 158.41 ? 150 ASN A ND2   1 
ATOM   1168 N  N     . HIS A 1 151 ? 137.294 131.787 158.819 1.00 138.24 ? 151 HIS A N     1 
ATOM   1169 C  CA    . HIS A 1 151 ? 137.133 132.141 160.216 1.00 138.24 ? 151 HIS A CA    1 
ATOM   1170 C  C     . HIS A 1 151 ? 136.519 130.965 160.978 1.00 138.24 ? 151 HIS A C     1 
ATOM   1171 O  O     . HIS A 1 151 ? 135.746 130.188 160.413 1.00 138.24 ? 151 HIS A O     1 
ATOM   1172 C  CB    . HIS A 1 151 ? 136.248 133.379 160.343 1.00 138.24 ? 151 HIS A CB    1 
ATOM   1173 C  CG    . HIS A 1 151 ? 136.531 134.207 161.556 1.00 138.24 ? 151 HIS A CG    1 
ATOM   1174 N  ND1   . HIS A 1 151 ? 135.977 133.939 162.789 1.00 138.24 ? 151 HIS A ND1   1 
ATOM   1175 C  CD2   . HIS A 1 151 ? 137.308 135.303 161.723 1.00 138.24 ? 151 HIS A CD2   1 
ATOM   1176 C  CE1   . HIS A 1 151 ? 136.403 134.832 163.665 1.00 138.24 ? 151 HIS A CE1   1 
ATOM   1177 N  NE2   . HIS A 1 151 ? 137.212 135.671 163.044 1.00 138.24 ? 151 HIS A NE2   1 
ATOM   1178 N  N     . PRO A 1 152 ? 136.860 130.804 162.260 1.00 128.39 ? 152 PRO A N     1 
ATOM   1179 C  CA    . PRO A 1 152 ? 136.313 129.673 163.029 1.00 128.39 ? 152 PRO A CA    1 
ATOM   1180 C  C     . PRO A 1 152 ? 134.793 129.608 163.039 1.00 128.39 ? 152 PRO A C     1 
ATOM   1181 O  O     . PRO A 1 152 ? 134.227 128.508 163.129 1.00 128.39 ? 152 PRO A O     1 
ATOM   1182 C  CB    . PRO A 1 152 ? 136.875 129.914 164.434 1.00 128.39 ? 152 PRO A CB    1 
ATOM   1183 C  CG    . PRO A 1 152 ? 138.171 130.602 164.188 1.00 128.39 ? 152 PRO A CG    1 
ATOM   1184 C  CD    . PRO A 1 152 ? 137.981 131.455 162.961 1.00 128.39 ? 152 PRO A CD    1 
ATOM   1185 N  N     . TYR A 1 153 ? 134.119 130.757 162.960 1.00 138.20 ? 153 TYR A N     1 
ATOM   1186 C  CA    . TYR A 1 153 ? 132.663 130.760 162.879 1.00 138.20 ? 153 TYR A CA    1 
ATOM   1187 C  C     . TYR A 1 153 ? 132.178 129.922 161.704 1.00 138.20 ? 153 TYR A C     1 
ATOM   1188 O  O     . TYR A 1 153 ? 131.210 129.161 161.828 1.00 138.20 ? 153 TYR A O     1 
ATOM   1189 C  CB    . TYR A 1 153 ? 132.151 132.194 162.748 1.00 138.20 ? 153 TYR A CB    1 
ATOM   1190 C  CG    . TYR A 1 153 ? 132.218 133.011 164.017 1.00 138.20 ? 153 TYR A CG    1 
ATOM   1191 C  CD1   . TYR A 1 153 ? 132.632 132.446 165.214 1.00 138.20 ? 153 TYR A CD1   1 
ATOM   1192 C  CD2   . TYR A 1 153 ? 131.869 134.354 164.015 1.00 138.20 ? 153 TYR A CD2   1 
ATOM   1193 C  CE1   . TYR A 1 153 ? 132.693 133.193 166.373 1.00 138.20 ? 153 TYR A CE1   1 
ATOM   1194 C  CE2   . TYR A 1 153 ? 131.928 135.109 165.167 1.00 138.20 ? 153 TYR A CE2   1 
ATOM   1195 C  CZ    . TYR A 1 153 ? 132.340 134.524 166.344 1.00 138.20 ? 153 TYR A CZ    1 
ATOM   1196 O  OH    . TYR A 1 153 ? 132.400 135.272 167.495 1.00 138.20 ? 153 TYR A OH    1 
ATOM   1197 N  N     . ARG A 1 154 ? 132.841 130.048 160.554 1.00 135.18 ? 154 ARG A N     1 
ATOM   1198 C  CA    . ARG A 1 154 ? 132.423 129.296 159.376 1.00 135.18 ? 154 ARG A CA    1 
ATOM   1199 C  C     . ARG A 1 154 ? 132.598 127.797 159.581 1.00 135.18 ? 154 ARG A C     1 
ATOM   1200 O  O     . ARG A 1 154 ? 131.764 127.005 159.133 1.00 135.18 ? 154 ARG A O     1 
ATOM   1201 C  CB    . ARG A 1 154 ? 133.198 129.771 158.148 1.00 135.18 ? 154 ARG A CB    1 
ATOM   1202 C  CG    . ARG A 1 154 ? 132.341 129.879 156.903 1.00 135.18 ? 154 ARG A CG    1 
ATOM   1203 C  CD    . ARG A 1 154 ? 132.827 130.979 155.984 1.00 135.18 ? 154 ARG A CD    1 
ATOM   1204 N  NE    . ARG A 1 154 ? 131.996 131.090 154.792 1.00 135.18 ? 154 ARG A NE    1 
ATOM   1205 C  CZ    . ARG A 1 154 ? 132.235 130.454 153.653 1.00 135.18 ? 154 ARG A CZ    1 
ATOM   1206 N  NH1   . ARG A 1 154 ? 133.278 129.653 153.515 1.00 135.18 ? 154 ARG A NH1   1 
ATOM   1207 N  NH2   . ARG A 1 154 ? 131.405 130.626 152.628 1.00 135.18 ? 154 ARG A NH2   1 
ATOM   1208 N  N     . GLN A 1 155 ? 133.677 127.382 160.250 1.00 134.10 ? 155 GLN A N     1 
ATOM   1209 C  CA    . GLN A 1 155 ? 133.867 125.959 160.516 1.00 134.10 ? 155 GLN A CA    1 
ATOM   1210 C  C     . GLN A 1 155 ? 132.812 125.430 161.480 1.00 134.10 ? 155 GLN A C     1 
ATOM   1211 O  O     . GLN A 1 155 ? 132.318 124.306 161.318 1.00 134.10 ? 155 GLN A O     1 
ATOM   1212 C  CB    . GLN A 1 155 ? 135.273 125.711 161.056 1.00 134.10 ? 155 GLN A CB    1 
ATOM   1213 C  CG    . GLN A 1 155 ? 136.327 126.613 160.446 1.00 134.10 ? 155 GLN A CG    1 
ATOM   1214 C  CD    . GLN A 1 155 ? 137.645 125.902 160.235 1.00 134.10 ? 155 GLN A CD    1 
ATOM   1215 O  OE1   . GLN A 1 155 ? 137.681 124.755 159.789 1.00 134.10 ? 155 GLN A OE1   1 
ATOM   1216 N  NE2   . GLN A 1 155 ? 138.742 126.581 160.551 1.00 134.10 ? 155 GLN A NE2   1 
ATOM   1217 N  N     . ILE A 1 156 ? 132.454 126.222 162.493 1.00 132.71 ? 156 ILE A N     1 
ATOM   1218 C  CA    . ILE A 1 156 ? 131.385 125.806 163.400 1.00 132.71 ? 156 ILE A CA    1 
ATOM   1219 C  C     . ILE A 1 156 ? 130.068 125.676 162.642 1.00 132.71 ? 156 ILE A C     1 
ATOM   1220 O  O     . ILE A 1 156 ? 129.291 124.740 162.869 1.00 132.71 ? 156 ILE A O     1 
ATOM   1221 C  CB    . ILE A 1 156 ? 131.270 126.785 164.583 1.00 132.71 ? 156 ILE A CB    1 
ATOM   1222 C  CG1   . ILE A 1 156 ? 132.571 126.799 165.384 1.00 132.71 ? 156 ILE A CG1   1 
ATOM   1223 C  CG2   . ILE A 1 156 ? 130.111 126.401 165.481 1.00 132.71 ? 156 ILE A CG2   1 
ATOM   1224 C  CD1   . ILE A 1 156 ? 132.655 127.921 166.390 1.00 132.71 ? 156 ILE A CD1   1 
ATOM   1225 N  N     . MET A 1 157 ? 129.803 126.602 161.720 1.00 141.36 ? 157 MET A N     1 
ATOM   1226 C  CA    . MET A 1 157 ? 128.612 126.497 160.879 1.00 141.36 ? 157 MET A CA    1 
ATOM   1227 C  C     . MET A 1 157 ? 128.651 125.244 160.013 1.00 141.36 ? 157 MET A C     1 
ATOM   1228 O  O     . MET A 1 157 ? 127.628 124.571 159.832 1.00 141.36 ? 157 MET A O     1 
ATOM   1229 C  CB    . MET A 1 157 ? 128.472 127.777 160.045 1.00 141.36 ? 157 MET A CB    1 
ATOM   1230 C  CG    . MET A 1 157 ? 127.587 127.757 158.786 1.00 141.36 ? 157 MET A CG    1 
ATOM   1231 S  SD    . MET A 1 157 ? 128.097 126.710 157.401 1.00 141.36 ? 157 MET A SD    1 
ATOM   1232 C  CE    . MET A 1 157 ? 129.498 127.644 156.797 1.00 141.36 ? 157 MET A CE    1 
ATOM   1233 N  N     . ARG A 1 158 ? 129.820 124.924 159.455 1.00 143.85 ? 158 ARG A N     1 
ATOM   1234 C  CA    . ARG A 1 158 ? 129.962 123.711 158.659 1.00 143.85 ? 158 ARG A CA    1 
ATOM   1235 C  C     . ARG A 1 158 ? 129.654 122.476 159.493 1.00 143.85 ? 158 ARG A C     1 
ATOM   1236 O  O     . ARG A 1 158 ? 129.019 121.531 159.012 1.00 143.85 ? 158 ARG A O     1 
ATOM   1237 C  CB    . ARG A 1 158 ? 131.372 123.630 158.077 1.00 143.85 ? 158 ARG A CB    1 
ATOM   1238 C  CG    . ARG A 1 158 ? 131.692 122.313 157.395 1.00 143.85 ? 158 ARG A CG    1 
ATOM   1239 C  CD    . ARG A 1 158 ? 133.008 122.393 156.642 1.00 143.85 ? 158 ARG A CD    1 
ATOM   1240 N  NE    . ARG A 1 158 ? 133.299 123.749 156.194 1.00 143.85 ? 158 ARG A NE    1 
ATOM   1241 C  CZ    . ARG A 1 158 ? 133.024 124.212 154.983 1.00 143.85 ? 158 ARG A CZ    1 
ATOM   1242 N  NH1   . ARG A 1 158 ? 132.440 123.455 154.068 1.00 143.85 ? 158 ARG A NH1   1 
ATOM   1243 N  NH2   . ARG A 1 158 ? 133.342 125.468 154.680 1.00 143.85 ? 158 ARG A NH2   1 
ATOM   1244 N  N     . HIS A 1 159 ? 130.101 122.472 160.748 1.00 142.71 ? 159 HIS A N     1 
ATOM   1245 C  CA    . HIS A 1 159 ? 129.704 121.412 161.670 1.00 142.71 ? 159 HIS A CA    1 
ATOM   1246 C  C     . HIS A 1 159 ? 128.192 121.392 161.858 1.00 142.71 ? 159 HIS A C     1 
ATOM   1247 O  O     . HIS A 1 159 ? 127.578 120.320 161.921 1.00 142.71 ? 159 HIS A O     1 
ATOM   1248 C  CB    . HIS A 1 159 ? 130.404 121.602 163.014 1.00 142.71 ? 159 HIS A CB    1 
ATOM   1249 C  CG    . HIS A 1 159 ? 131.582 120.702 163.213 1.00 142.71 ? 159 HIS A CG    1 
ATOM   1250 N  ND1   . HIS A 1 159 ? 131.478 119.328 163.213 1.00 142.71 ? 159 HIS A ND1   1 
ATOM   1251 C  CD2   . HIS A 1 159 ? 132.890 120.981 163.429 1.00 142.71 ? 159 HIS A CD2   1 
ATOM   1252 C  CE1   . HIS A 1 159 ? 132.670 118.799 163.416 1.00 142.71 ? 159 HIS A CE1   1 
ATOM   1253 N  NE2   . HIS A 1 159 ? 133.545 119.779 163.549 1.00 142.71 ? 159 HIS A NE2   1 
ATOM   1254 N  N     . TYR A 1 160 ? 127.580 122.573 161.955 1.00 142.08 ? 160 TYR A N     1 
ATOM   1255 C  CA    . TYR A 1 160 ? 126.141 122.662 162.182 1.00 142.08 ? 160 TYR A CA    1 
ATOM   1256 C  C     . TYR A 1 160 ? 125.337 122.106 161.014 1.00 142.08 ? 160 TYR A C     1 
ATOM   1257 O  O     . TYR A 1 160 ? 124.248 121.557 161.221 1.00 142.08 ? 160 TYR A O     1 
ATOM   1258 C  CB    . TYR A 1 160 ? 125.745 124.116 162.451 1.00 142.08 ? 160 TYR A CB    1 
ATOM   1259 C  CG    . TYR A 1 160 ? 124.311 124.462 162.102 1.00 142.08 ? 160 TYR A CG    1 
ATOM   1260 C  CD1   . TYR A 1 160 ? 123.292 124.303 163.031 1.00 142.08 ? 160 TYR A CD1   1 
ATOM   1261 C  CD2   . TYR A 1 160 ? 123.981 124.975 160.852 1.00 142.08 ? 160 TYR A CD2   1 
ATOM   1262 C  CE1   . TYR A 1 160 ? 121.984 124.625 162.719 1.00 142.08 ? 160 TYR A CE1   1 
ATOM   1263 C  CE2   . TYR A 1 160 ? 122.675 125.296 160.532 1.00 142.08 ? 160 TYR A CE2   1 
ATOM   1264 C  CZ    . TYR A 1 160 ? 121.682 125.121 161.470 1.00 142.08 ? 160 TYR A CZ    1 
ATOM   1265 O  OH    . TYR A 1 160 ? 120.381 125.444 161.157 1.00 142.08 ? 160 TYR A OH    1 
ATOM   1266 N  N     . LYS A 1 161 ? 125.847 122.243 159.788 1.00 161.80 ? 161 LYS A N     1 
ATOM   1267 C  CA    . LYS A 1 161 ? 125.029 121.958 158.610 1.00 161.80 ? 161 LYS A CA    1 
ATOM   1268 C  C     . LYS A 1 161 ? 124.556 120.507 158.582 1.00 161.80 ? 161 LYS A C     1 
ATOM   1269 O  O     . LYS A 1 161 ? 123.393 120.234 158.262 1.00 161.80 ? 161 LYS A O     1 
ATOM   1270 C  CB    . LYS A 1 161 ? 125.809 122.289 157.338 1.00 161.80 ? 161 LYS A CB    1 
ATOM   1271 C  CG    . LYS A 1 161 ? 125.250 121.636 156.083 1.00 161.80 ? 161 LYS A CG    1 
ATOM   1272 C  CD    . LYS A 1 161 ? 126.307 121.506 154.999 1.00 161.80 ? 161 LYS A CD    1 
ATOM   1273 C  CE    . LYS A 1 161 ? 127.525 120.749 155.499 1.00 161.80 ? 161 LYS A CE    1 
ATOM   1274 N  NZ    . LYS A 1 161 ? 128.472 120.435 154.394 1.00 161.80 ? 161 LYS A NZ    1 
ATOM   1275 N  N     . ASN A 1 162 ? 125.438 119.563 158.917 1.00 169.59 ? 162 ASN A N     1 
ATOM   1276 C  CA    . ASN A 1 162 ? 125.108 118.148 158.776 1.00 169.59 ? 162 ASN A CA    1 
ATOM   1277 C  C     . ASN A 1 162 ? 124.044 117.677 159.761 1.00 169.59 ? 162 ASN A C     1 
ATOM   1278 O  O     . ASN A 1 162 ? 123.441 116.622 159.538 1.00 169.59 ? 162 ASN A O     1 
ATOM   1279 C  CB    . ASN A 1 162 ? 126.367 117.296 158.937 1.00 169.59 ? 162 ASN A CB    1 
ATOM   1280 C  CG    . ASN A 1 162 ? 127.317 117.434 157.764 1.00 169.59 ? 162 ASN A CG    1 
ATOM   1281 O  OD1   . ASN A 1 162 ? 126.909 117.797 156.661 1.00 169.59 ? 162 ASN A OD1   1 
ATOM   1282 N  ND2   . ASN A 1 162 ? 128.592 117.143 157.996 1.00 169.59 ? 162 ASN A ND2   1 
ATOM   1283 N  N     . LEU A 1 163 ? 123.802 118.420 160.837 1.00 151.23 ? 163 LEU A N     1 
ATOM   1284 C  CA    . LEU A 1 163 ? 122.853 117.980 161.851 1.00 151.23 ? 163 LEU A CA    1 
ATOM   1285 C  C     . LEU A 1 163 ? 121.428 117.978 161.305 1.00 151.23 ? 163 LEU A C     1 
ATOM   1286 O  O     . LEU A 1 163 ? 121.074 118.761 160.419 1.00 151.23 ? 163 LEU A O     1 
ATOM   1287 C  CB    . LEU A 1 163 ? 122.939 118.878 163.085 1.00 151.23 ? 163 LEU A CB    1 
ATOM   1288 C  CG    . LEU A 1 163 ? 122.345 118.308 164.373 1.00 151.23 ? 163 LEU A CG    1 
ATOM   1289 C  CD1   . LEU A 1 163 ? 123.338 117.382 165.055 1.00 151.23 ? 163 LEU A CD1   1 
ATOM   1290 C  CD2   . LEU A 1 163 ? 121.916 119.423 165.311 1.00 151.23 ? 163 LEU A CD2   1 
ATOM   1291 N  N     . GLU A 1 164 ? 120.607 117.078 161.844 1.00 160.20 ? 164 GLU A N     1 
ATOM   1292 C  CA    . GLU A 1 164 ? 119.211 116.988 161.442 1.00 160.20 ? 164 GLU A CA    1 
ATOM   1293 C  C     . GLU A 1 164 ? 118.428 118.201 161.939 1.00 160.20 ? 164 GLU A C     1 
ATOM   1294 O  O     . GLU A 1 164 ? 118.715 118.773 162.993 1.00 160.20 ? 164 GLU A O     1 
ATOM   1295 C  CB    . GLU A 1 164 ? 118.579 115.703 161.974 1.00 160.20 ? 164 GLU A CB    1 
ATOM   1296 C  CG    . GLU A 1 164 ? 118.925 114.465 161.168 1.00 160.20 ? 164 GLU A CG    1 
ATOM   1297 C  CD    . GLU A 1 164 ? 118.231 113.223 161.685 1.00 160.20 ? 164 GLU A CD    1 
ATOM   1298 O  OE1   . GLU A 1 164 ? 117.634 113.287 162.781 1.00 160.20 ? 164 GLU A OE1   1 
ATOM   1299 O  OE2   . GLU A 1 164 ? 118.279 112.182 160.996 1.00 160.20 ? 164 GLU A OE2   1 
ATOM   1300 N  N     . GLN A 1 165 ? 117.411 118.580 161.162 1.00 156.05 ? 165 GLN A N     1 
ATOM   1301 C  CA    . GLN A 1 165 ? 116.684 119.818 161.422 1.00 156.05 ? 165 GLN A CA    1 
ATOM   1302 C  C     . GLN A 1 165 ? 115.816 119.751 162.671 1.00 156.05 ? 165 GLN A C     1 
ATOM   1303 O  O     . GLN A 1 165 ? 115.398 120.801 163.171 1.00 156.05 ? 165 GLN A O     1 
ATOM   1304 C  CB    . GLN A 1 165 ? 115.812 120.174 160.216 1.00 156.05 ? 165 GLN A CB    1 
ATOM   1305 C  CG    . GLN A 1 165 ? 114.449 119.497 160.212 1.00 156.05 ? 165 GLN A CG    1 
ATOM   1306 C  CD    . GLN A 1 165 ? 114.530 118.005 159.947 1.00 156.05 ? 165 GLN A CD    1 
ATOM   1307 O  OE1   . GLN A 1 165 ? 115.587 117.477 159.600 1.00 156.05 ? 165 GLN A OE1   1 
ATOM   1308 N  NE2   . GLN A 1 165 ? 113.408 117.316 160.114 1.00 156.05 ? 165 GLN A NE2   1 
ATOM   1309 N  N     . ASN A 1 166 ? 115.528 118.554 163.182 1.00 149.74 ? 166 ASN A N     1 
ATOM   1310 C  CA    . ASN A 1 166 ? 114.623 118.443 164.323 1.00 149.74 ? 166 ASN A CA    1 
ATOM   1311 C  C     . ASN A 1 166 ? 115.229 119.050 165.583 1.00 149.74 ? 166 ASN A C     1 
ATOM   1312 O  O     . ASN A 1 166 ? 114.546 119.772 166.319 1.00 149.74 ? 166 ASN A O     1 
ATOM   1313 C  CB    . ASN A 1 166 ? 114.252 116.982 164.561 1.00 149.74 ? 166 ASN A CB    1 
ATOM   1314 C  CG    . ASN A 1 166 ? 113.221 116.817 165.659 1.00 149.74 ? 166 ASN A CG    1 
ATOM   1315 O  OD1   . ASN A 1 166 ? 113.561 116.730 166.839 1.00 149.74 ? 166 ASN A OD1   1 
ATOM   1316 N  ND2   . ASN A 1 166 ? 111.950 116.778 165.275 1.00 149.74 ? 166 ASN A ND2   1 
ATOM   1317 N  N     . ASP A 1 167 ? 116.502 118.770 165.852 1.00 159.28 ? 167 ASP A N     1 
ATOM   1318 C  CA    . ASP A 1 167 ? 117.159 119.218 167.073 1.00 159.28 ? 167 ASP A CA    1 
ATOM   1319 C  C     . ASP A 1 167 ? 118.097 120.398 166.849 1.00 159.28 ? 167 ASP A C     1 
ATOM   1320 O  O     . ASP A 1 167 ? 118.893 120.717 167.738 1.00 159.28 ? 167 ASP A O     1 
ATOM   1321 C  CB    . ASP A 1 167 ? 117.920 118.056 167.714 1.00 159.28 ? 167 ASP A CB    1 
ATOM   1322 C  CG    . ASP A 1 167 ? 118.556 117.141 166.689 1.00 159.28 ? 167 ASP A CG    1 
ATOM   1323 O  OD1   . ASP A 1 167 ? 118.484 117.456 165.483 1.00 159.28 ? 167 ASP A OD1   1 
ATOM   1324 O  OD2   . ASP A 1 167 ? 119.127 116.104 167.088 1.00 159.28 ? 167 ASP A OD2   1 
ATOM   1325 N  N     . ARG A 1 168 ? 118.028 121.047 165.694 1.00 144.79 ? 168 ARG A N     1 
ATOM   1326 C  CA    . ARG A 1 168 ? 118.878 122.206 165.443 1.00 144.79 ? 168 ARG A CA    1 
ATOM   1327 C  C     . ARG A 1 168 ? 118.473 123.358 166.355 1.00 144.79 ? 168 ARG A C     1 
ATOM   1328 O  O     . ARG A 1 168 ? 117.283 123.682 166.446 1.00 144.79 ? 168 ARG A O     1 
ATOM   1329 C  CB    . ARG A 1 168 ? 118.785 122.643 163.985 1.00 144.79 ? 168 ARG A CB    1 
ATOM   1330 C  CG    . ARG A 1 168 ? 119.549 121.769 163.016 1.00 144.79 ? 168 ARG A CG    1 
ATOM   1331 C  CD    . ARG A 1 168 ? 119.460 122.324 161.609 1.00 144.79 ? 168 ARG A CD    1 
ATOM   1332 N  NE    . ARG A 1 168 ? 118.107 122.762 161.292 1.00 144.79 ? 168 ARG A NE    1 
ATOM   1333 C  CZ    . ARG A 1 168 ? 117.746 123.299 160.134 1.00 144.79 ? 168 ARG A CZ    1 
ATOM   1334 N  NH1   . ARG A 1 168 ? 118.616 123.478 159.155 1.00 144.79 ? 168 ARG A NH1   1 
ATOM   1335 N  NH2   . ARG A 1 168 ? 116.480 123.664 159.957 1.00 144.79 ? 168 ARG A NH2   1 
ATOM   1336 N  N     . PRO A 1 169 ? 119.416 123.997 167.038 1.00 131.78 ? 169 PRO A N     1 
ATOM   1337 C  CA    . PRO A 1 169 ? 119.079 125.160 167.860 1.00 131.78 ? 169 PRO A CA    1 
ATOM   1338 C  C     . PRO A 1 169 ? 118.873 126.409 167.014 1.00 131.78 ? 169 PRO A C     1 
ATOM   1339 O  O     . PRO A 1 169 ? 119.215 126.462 165.831 1.00 131.78 ? 169 PRO A O     1 
ATOM   1340 C  CB    . PRO A 1 169 ? 120.301 125.308 168.771 1.00 131.78 ? 169 PRO A CB    1 
ATOM   1341 C  CG    . PRO A 1 169 ? 121.423 124.757 167.958 1.00 131.78 ? 169 PRO A CG    1 
ATOM   1342 C  CD    . PRO A 1 169 ? 120.843 123.645 167.127 1.00 131.78 ? 169 PRO A CD    1 
ATOM   1343 N  N     . ARG A 1 170 ? 118.297 127.425 167.651 1.00 137.74 ? 170 ARG A N     1 
ATOM   1344 C  CA    . ARG A 1 170 ? 118.079 128.703 166.988 1.00 137.74 ? 170 ARG A CA    1 
ATOM   1345 C  C     . ARG A 1 170 ? 119.389 129.474 166.856 1.00 137.74 ? 170 ARG A C     1 
ATOM   1346 O  O     . ARG A 1 170 ? 120.309 129.324 167.664 1.00 137.74 ? 170 ARG A O     1 
ATOM   1347 C  CB    . ARG A 1 170 ? 117.058 129.536 167.762 1.00 137.74 ? 170 ARG A CB    1 
ATOM   1348 C  CG    . ARG A 1 170 ? 116.364 130.603 166.933 1.00 137.74 ? 170 ARG A CG    1 
ATOM   1349 C  CD    . ARG A 1 170 ? 115.143 131.153 167.649 1.00 137.74 ? 170 ARG A CD    1 
ATOM   1350 N  NE    . ARG A 1 170 ? 114.027 130.217 167.621 1.00 137.74 ? 170 ARG A NE    1 
ATOM   1351 C  CZ    . ARG A 1 170 ? 113.402 129.765 168.700 1.00 137.74 ? 170 ARG A CZ    1 
ATOM   1352 N  NH1   . ARG A 1 170 ? 113.764 130.142 169.916 1.00 137.74 ? 170 ARG A NH1   1 
ATOM   1353 N  NH2   . ARG A 1 170 ? 112.392 128.914 168.556 1.00 137.74 ? 170 ARG A NH2   1 
ATOM   1354 N  N     . ILE A 1 171 ? 119.466 130.307 165.821 1.00 136.15 ? 171 ILE A N     1 
ATOM   1355 C  CA    . ILE A 1 171 ? 120.638 131.133 165.550 1.00 136.15 ? 171 ILE A CA    1 
ATOM   1356 C  C     . ILE A 1 171 ? 120.212 132.594 165.555 1.00 136.15 ? 171 ILE A C     1 
ATOM   1357 O  O     . ILE A 1 171 ? 119.255 132.969 164.868 1.00 136.15 ? 171 ILE A O     1 
ATOM   1358 C  CB    . ILE A 1 171 ? 121.301 130.767 164.210 1.00 136.15 ? 171 ILE A CB    1 
ATOM   1359 C  CG1   . ILE A 1 171 ? 121.478 129.253 164.090 1.00 136.15 ? 171 ILE A CG1   1 
ATOM   1360 C  CG2   . ILE A 1 171 ? 122.639 131.469 164.072 1.00 136.15 ? 171 ILE A CG2   1 
ATOM   1361 C  CD1   . ILE A 1 171 ? 120.694 128.635 162.954 1.00 136.15 ? 171 ILE A CD1   1 
ATOM   1362 N  N     . LEU A 1 172 ? 120.924 133.413 166.328 1.00 165.92 ? 172 LEU A N     1 
ATOM   1363 C  CA    . LEU A 1 172 ? 120.668 134.843 166.415 1.00 165.92 ? 172 LEU A CA    1 
ATOM   1364 C  C     . LEU A 1 172 ? 121.972 135.599 166.205 1.00 165.92 ? 172 LEU A C     1 
ATOM   1365 O  O     . LEU A 1 172 ? 123.021 135.193 166.712 1.00 165.92 ? 172 LEU A O     1 
ATOM   1366 C  CB    . LEU A 1 172 ? 120.055 135.218 167.768 1.00 165.92 ? 172 LEU A CB    1 
ATOM   1367 C  CG    . LEU A 1 172 ? 119.591 136.666 167.923 1.00 165.92 ? 172 LEU A CG    1 
ATOM   1368 C  CD1   . LEU A 1 172 ? 118.294 136.888 167.163 1.00 165.92 ? 172 LEU A CD1   1 
ATOM   1369 C  CD2   . LEU A 1 172 ? 119.425 137.020 169.391 1.00 165.92 ? 172 LEU A CD2   1 
ATOM   1370 N  N     . GLY A 1 173 ? 121.902 136.695 165.462 1.00 176.43 ? 173 GLY A N     1 
ATOM   1371 C  CA    . GLY A 1 173 ? 123.083 137.468 165.104 1.00 176.43 ? 173 GLY A CA    1 
ATOM   1372 C  C     . GLY A 1 173 ? 123.025 138.882 165.645 1.00 176.43 ? 173 GLY A C     1 
ATOM   1373 O  O     . GLY A 1 173 ? 121.977 139.529 165.600 1.00 176.43 ? 173 GLY A O     1 
ATOM   1374 N  N     . LEU A 1 174 ? 124.162 139.356 166.152 1.00 182.55 ? 174 LEU A N     1 
ATOM   1375 C  CA    . LEU A 1 174 ? 124.307 140.716 166.655 1.00 182.55 ? 174 LEU A CA    1 
ATOM   1376 C  C     . LEU A 1 174 ? 125.484 141.377 165.954 1.00 182.55 ? 174 LEU A C     1 
ATOM   1377 O  O     . LEU A 1 174 ? 126.580 140.808 165.911 1.00 182.55 ? 174 LEU A O     1 
ATOM   1378 C  CB    . LEU A 1 174 ? 124.526 140.732 168.171 1.00 182.55 ? 174 LEU A CB    1 
ATOM   1379 C  CG    . LEU A 1 174 ? 123.453 140.083 169.045 1.00 182.55 ? 174 LEU A CG    1 
ATOM   1380 C  CD1   . LEU A 1 174 ? 123.854 140.144 170.509 1.00 182.55 ? 174 LEU A CD1   1 
ATOM   1381 C  CD2   . LEU A 1 174 ? 122.108 140.755 168.824 1.00 182.55 ? 174 LEU A CD2   1 
ATOM   1382 N  N     . THR A 1 175 ? 125.262 142.571 165.412 1.00 169.04 ? 175 THR A N     1 
ATOM   1383 C  CA    . THR A 1 175 ? 126.329 143.300 164.740 1.00 169.04 ? 175 THR A CA    1 
ATOM   1384 C  C     . THR A 1 175 ? 125.973 144.776 164.676 1.00 169.04 ? 175 THR A C     1 
ATOM   1385 O  O     . THR A 1 175 ? 124.808 145.164 164.802 1.00 169.04 ? 175 THR A O     1 
ATOM   1386 C  CB    . THR A 1 175 ? 126.583 142.762 163.327 1.00 169.04 ? 175 THR A CB    1 
ATOM   1387 O  OG1   . THR A 1 175 ? 127.741 143.400 162.772 1.00 169.04 ? 175 THR A OG1   1 
ATOM   1388 C  CG2   . THR A 1 175 ? 125.388 143.031 162.429 1.00 169.04 ? 175 THR A CG2   1 
ATOM   1389 N  N     . ALA A 1 176 ? 127.005 145.595 164.486 1.00 141.16 ? 176 ALA A N     1 
ATOM   1390 C  CA    . ALA A 1 176 ? 126.848 147.006 164.166 1.00 141.16 ? 176 ALA A CA    1 
ATOM   1391 C  C     . ALA A 1 176 ? 127.281 147.342 162.749 1.00 141.16 ? 176 ALA A C     1 
ATOM   1392 O  O     . ALA A 1 176 ? 126.781 148.311 162.175 1.00 141.16 ? 176 ALA A O     1 
ATOM   1393 C  CB    . ALA A 1 176 ? 127.644 147.872 165.151 1.00 141.16 ? 176 ALA A CB    1 
ATOM   1394 N  N     . SER A 1 177 ? 128.193 146.560 162.179 1.00 147.11 ? 177 SER A N     1 
ATOM   1395 C  CA    . SER A 1 177 ? 128.622 146.694 160.796 1.00 147.11 ? 177 SER A CA    1 
ATOM   1396 C  C     . SER A 1 177 ? 128.361 145.383 160.071 1.00 147.11 ? 177 SER A C     1 
ATOM   1397 O  O     . SER A 1 177 ? 128.362 144.313 160.687 1.00 147.11 ? 177 SER A O     1 
ATOM   1398 C  CB    . SER A 1 177 ? 130.107 147.054 160.704 1.00 147.11 ? 177 SER A CB    1 
ATOM   1399 O  OG    . SER A 1 177 ? 130.919 145.906 160.888 1.00 147.11 ? 177 SER A OG    1 
ATOM   1400 N  N     . VAL A 1 178 ? 128.133 145.469 158.765 1.00 167.88 ? 178 VAL A N     1 
ATOM   1401 C  CA    . VAL A 1 178 ? 127.817 144.299 157.958 1.00 167.88 ? 178 VAL A CA    1 
ATOM   1402 C  C     . VAL A 1 178 ? 128.978 143.906 157.053 1.00 167.88 ? 178 VAL A C     1 
ATOM   1403 O  O     . VAL A 1 178 ? 129.334 142.730 156.976 1.00 167.88 ? 178 VAL A O     1 
ATOM   1404 C  CB    . VAL A 1 178 ? 126.533 144.548 157.139 1.00 167.88 ? 178 VAL A CB    1 
ATOM   1405 C  CG1   . VAL A 1 178 ? 126.219 143.346 156.264 1.00 167.88 ? 178 VAL A CG1   1 
ATOM   1406 C  CG2   . VAL A 1 178 ? 125.370 144.854 158.066 1.00 167.88 ? 178 VAL A CG2   1 
ATOM   1407 N  N     . ILE A 1 179 ? 129.581 144.872 156.367 1.00 163.98 ? 179 ILE A N     1 
ATOM   1408 C  CA    . ILE A 1 179 ? 130.642 144.606 155.402 1.00 163.98 ? 179 ILE A CA    1 
ATOM   1409 C  C     . ILE A 1 179 ? 131.984 144.686 156.114 1.00 163.98 ? 179 ILE A C     1 
ATOM   1410 O  O     . ILE A 1 179 ? 132.251 145.642 156.852 1.00 163.98 ? 179 ILE A O     1 
ATOM   1411 C  CB    . ILE A 1 179 ? 130.583 145.588 154.221 1.00 163.98 ? 179 ILE A CB    1 
ATOM   1412 C  CG1   . ILE A 1 179 ? 129.152 145.697 153.692 1.00 163.98 ? 179 ILE A CG1   1 
ATOM   1413 C  CG2   . ILE A 1 179 ? 131.500 145.119 153.112 1.00 163.98 ? 179 ILE A CG2   1 
ATOM   1414 C  CD1   . ILE A 1 179 ? 128.458 146.989 154.059 1.00 163.98 ? 179 ILE A CD1   1 
ATOM   1415 N  N     . ASN A 1 180 ? 132.831 143.676 155.895 1.00 169.03 ? 180 ASN A N     1 
ATOM   1416 C  CA    . ASN A 1 180 ? 134.099 143.596 156.613 1.00 169.03 ? 180 ASN A CA    1 
ATOM   1417 C  C     . ASN A 1 180 ? 135.131 144.569 156.053 1.00 169.03 ? 180 ASN A C     1 
ATOM   1418 O  O     . ASN A 1 180 ? 135.952 145.109 156.803 1.00 169.03 ? 180 ASN A O     1 
ATOM   1419 C  CB    . ASN A 1 180 ? 134.634 142.166 156.566 1.00 169.03 ? 180 ASN A CB    1 
ATOM   1420 C  CG    . ASN A 1 180 ? 135.584 141.862 157.706 1.00 169.03 ? 180 ASN A CG    1 
ATOM   1421 O  OD1   . ASN A 1 180 ? 135.905 142.735 158.510 1.00 169.03 ? 180 ASN A OD1   1 
ATOM   1422 N  ND2   . ASN A 1 180 ? 136.040 140.618 157.779 1.00 169.03 ? 180 ASN A ND2   1 
ATOM   1423 N  N     . SER A 1 181 ? 135.118 144.797 154.742 1.00 193.62 ? 181 SER A N     1 
ATOM   1424 C  CA    . SER A 1 181 ? 136.124 145.620 154.084 1.00 193.62 ? 181 SER A CA    1 
ATOM   1425 C  C     . SER A 1 181 ? 135.446 146.602 153.136 1.00 193.62 ? 181 SER A C     1 
ATOM   1426 O  O     . SER A 1 181 ? 134.217 146.713 153.092 1.00 193.62 ? 181 SER A O     1 
ATOM   1427 C  CB    . SER A 1 181 ? 137.141 144.751 153.332 1.00 193.62 ? 181 SER A CB    1 
ATOM   1428 O  OG    . SER A 1 181 ? 137.791 145.491 152.314 1.00 193.62 ? 181 SER A OG    1 
ATOM   1429 N  N     . LYS A 1 182 ? 136.263 147.331 152.380 1.00 207.51 ? 182 LYS A N     1 
ATOM   1430 C  CA    . LYS A 1 182 ? 135.736 148.231 151.363 1.00 207.51 ? 182 LYS A CA    1 
ATOM   1431 C  C     . LYS A 1 182 ? 135.051 147.429 150.265 1.00 207.51 ? 182 LYS A C     1 
ATOM   1432 O  O     . LYS A 1 182 ? 135.590 146.430 149.779 1.00 207.51 ? 182 LYS A O     1 
ATOM   1433 C  CB    . LYS A 1 182 ? 136.860 149.086 150.779 1.00 207.51 ? 182 LYS A CB    1 
ATOM   1434 C  CG    . LYS A 1 182 ? 136.405 150.134 149.770 1.00 207.51 ? 182 LYS A CG    1 
ATOM   1435 C  CD    . LYS A 1 182 ? 135.128 150.833 150.213 1.00 207.51 ? 182 LYS A CD    1 
ATOM   1436 C  CE    . LYS A 1 182 ? 134.567 151.712 149.107 1.00 207.51 ? 182 LYS A CE    1 
ATOM   1437 N  NZ    . LYS A 1 182 ? 135.500 152.816 148.750 1.00 207.51 ? 182 LYS A NZ    1 
ATOM   1438 N  N     . CYS A 1 183 ? 133.861 147.872 149.872 1.00 216.38 ? 183 CYS A N     1 
ATOM   1439 C  CA    . CYS A 1 183 ? 133.069 147.187 148.865 1.00 216.38 ? 183 CYS A CA    1 
ATOM   1440 C  C     . CYS A 1 183 ? 132.555 148.189 147.845 1.00 216.38 ? 183 CYS A C     1 
ATOM   1441 O  O     . CYS A 1 183 ? 132.374 149.371 148.148 1.00 216.38 ? 183 CYS A O     1 
ATOM   1442 C  CB    . CYS A 1 183 ? 131.884 146.447 149.494 1.00 216.38 ? 183 CYS A CB    1 
ATOM   1443 S  SG    . CYS A 1 183 ? 130.880 147.484 150.581 1.00 216.38 ? 183 CYS A SG    1 
ATOM   1444 N  N     . LYS A 1 184 ? 132.329 147.706 146.629 1.00 221.89 ? 184 LYS A N     1 
ATOM   1445 C  CA    . LYS A 1 184 ? 131.674 148.525 145.625 1.00 221.89 ? 184 LYS A CA    1 
ATOM   1446 C  C     . LYS A 1 184 ? 130.202 148.703 145.994 1.00 221.89 ? 184 LYS A C     1 
ATOM   1447 O  O     . LYS A 1 184 ? 129.628 147.869 146.698 1.00 221.89 ? 184 LYS A O     1 
ATOM   1448 C  CB    . LYS A 1 184 ? 131.796 147.887 144.243 1.00 221.89 ? 184 LYS A CB    1 
ATOM   1449 C  CG    . LYS A 1 184 ? 133.021 148.312 143.432 1.00 221.89 ? 184 LYS A CG    1 
ATOM   1450 C  CD    . LYS A 1 184 ? 134.188 148.746 144.307 1.00 221.89 ? 184 LYS A CD    1 
ATOM   1451 C  CE    . LYS A 1 184 ? 135.410 149.092 143.471 1.00 221.89 ? 184 LYS A CE    1 
ATOM   1452 N  NZ    . LYS A 1 184 ? 136.601 149.369 144.320 1.00 221.89 ? 184 LYS A NZ    1 
ATOM   1453 N  N     . PRO A 1 185 ? 129.573 149.792 145.546 1.00 205.53 ? 185 PRO A N     1 
ATOM   1454 C  CA    . PRO A 1 185 ? 128.141 149.971 145.839 1.00 205.53 ? 185 PRO A CA    1 
ATOM   1455 C  C     . PRO A 1 185 ? 127.278 148.841 145.312 1.00 205.53 ? 185 PRO A C     1 
ATOM   1456 O  O     . PRO A 1 185 ? 126.251 148.519 145.922 1.00 205.53 ? 185 PRO A O     1 
ATOM   1457 C  CB    . PRO A 1 185 ? 127.810 151.304 145.156 1.00 205.53 ? 185 PRO A CB    1 
ATOM   1458 C  CG    . PRO A 1 185 ? 129.116 152.024 145.086 1.00 205.53 ? 185 PRO A CG    1 
ATOM   1459 C  CD    . PRO A 1 185 ? 130.145 150.959 144.854 1.00 205.53 ? 185 PRO A CD    1 
ATOM   1460 N  N     . ASN A 1 186 ? 127.663 148.228 144.193 1.00 224.38 ? 186 ASN A N     1 
ATOM   1461 C  CA    . ASN A 1 186 ? 126.888 147.126 143.635 1.00 224.38 ? 186 ASN A CA    1 
ATOM   1462 C  C     . ASN A 1 186 ? 127.115 145.826 144.400 1.00 224.38 ? 186 ASN A C     1 
ATOM   1463 O  O     . ASN A 1 186 ? 126.181 145.036 144.575 1.00 224.38 ? 186 ASN A O     1 
ATOM   1464 C  CB    . ASN A 1 186 ? 127.236 146.944 142.158 1.00 224.38 ? 186 ASN A CB    1 
ATOM   1465 C  CG    . ASN A 1 186 ? 126.994 148.199 141.345 1.00 224.38 ? 186 ASN A CG    1 
ATOM   1466 O  OD1   . ASN A 1 186 ? 126.206 149.061 141.734 1.00 224.38 ? 186 ASN A OD1   1 
ATOM   1467 N  ND2   . ASN A 1 186 ? 127.677 148.310 140.211 1.00 224.38 ? 186 ASN A ND2   1 
ATOM   1468 N  N     . GLN A 1 187 ? 128.344 145.589 144.865 1.00 225.42 ? 187 GLN A N     1 
ATOM   1469 C  CA    . GLN A 1 187 ? 128.685 144.321 145.503 1.00 225.42 ? 187 GLN A CA    1 
ATOM   1470 C  C     . GLN A 1 187 ? 128.100 144.172 146.901 1.00 225.42 ? 187 GLN A C     1 
ATOM   1471 O  O     . GLN A 1 187 ? 128.178 143.075 147.469 1.00 225.42 ? 187 GLN A O     1 
ATOM   1472 C  CB    . GLN A 1 187 ? 130.205 144.159 145.566 1.00 225.42 ? 187 GLN A CB    1 
ATOM   1473 C  CG    . GLN A 1 187 ? 130.902 144.288 144.222 1.00 225.42 ? 187 GLN A CG    1 
ATOM   1474 C  CD    . GLN A 1 187 ? 132.411 144.349 144.351 1.00 225.42 ? 187 GLN A CD    1 
ATOM   1475 O  OE1   . GLN A 1 187 ? 132.954 144.267 145.453 1.00 225.42 ? 187 GLN A OE1   1 
ATOM   1476 N  NE2   . GLN A 1 187 ? 133.097 144.495 143.225 1.00 225.42 ? 187 GLN A NE2   1 
ATOM   1477 N  N     . VAL A 1 188 ? 127.526 145.237 147.468 1.00 193.80 ? 188 VAL A N     1 
ATOM   1478 C  CA    . VAL A 1 188 ? 126.945 145.148 148.805 1.00 193.80 ? 188 VAL A CA    1 
ATOM   1479 C  C     . VAL A 1 188 ? 125.837 144.104 148.834 1.00 193.80 ? 188 VAL A C     1 
ATOM   1480 O  O     . VAL A 1 188 ? 125.700 143.346 149.805 1.00 193.80 ? 188 VAL A O     1 
ATOM   1481 C  CB    . VAL A 1 188 ? 126.432 146.528 149.256 1.00 193.80 ? 188 VAL A CB    1 
ATOM   1482 C  CG1   . VAL A 1 188 ? 125.817 146.443 150.645 1.00 193.80 ? 188 VAL A CG1   1 
ATOM   1483 C  CG2   . VAL A 1 188 ? 127.554 147.551 149.224 1.00 193.80 ? 188 VAL A CG2   1 
ATOM   1484 N  N     . GLU A 1 189 ? 125.030 144.049 147.772 1.00 198.28 ? 189 GLU A N     1 
ATOM   1485 C  CA    . GLU A 1 189 ? 123.966 143.055 147.702 1.00 198.28 ? 189 GLU A CA    1 
ATOM   1486 C  C     . GLU A 1 189 ? 124.529 141.640 147.732 1.00 198.28 ? 189 GLU A C     1 
ATOM   1487 O  O     . GLU A 1 189 ? 124.017 140.777 148.450 1.00 198.28 ? 189 GLU A O     1 
ATOM   1488 C  CB    . GLU A 1 189 ? 123.127 143.272 146.443 1.00 198.28 ? 189 GLU A CB    1 
ATOM   1489 C  CG    . GLU A 1 189 ? 121.894 142.386 146.355 1.00 198.28 ? 189 GLU A CG    1 
ATOM   1490 C  CD    . GLU A 1 189 ? 120.928 142.606 147.504 1.00 198.28 ? 189 GLU A CD    1 
ATOM   1491 O  OE1   . GLU A 1 189 ? 120.842 143.748 148.003 1.00 198.28 ? 189 GLU A OE1   1 
ATOM   1492 O  OE2   . GLU A 1 189 ? 120.254 141.635 147.907 1.00 198.28 ? 189 GLU A OE2   1 
ATOM   1493 N  N     . LYS A 1 190 ? 125.593 141.387 146.966 1.00 196.32 ? 190 LYS A N     1 
ATOM   1494 C  CA    . LYS A 1 190 ? 126.189 140.056 146.957 1.00 196.32 ? 190 LYS A CA    1 
ATOM   1495 C  C     . LYS A 1 190 ? 126.783 139.706 148.317 1.00 196.32 ? 190 LYS A C     1 
ATOM   1496 O  O     . LYS A 1 190 ? 126.639 138.572 148.789 1.00 196.32 ? 190 LYS A O     1 
ATOM   1497 C  CB    . LYS A 1 190 ? 127.250 139.960 145.862 1.00 196.32 ? 190 LYS A CB    1 
ATOM   1498 C  CG    . LYS A 1 190 ? 127.787 138.554 145.647 1.00 196.32 ? 190 LYS A CG    1 
ATOM   1499 C  CD    . LYS A 1 190 ? 129.192 138.568 145.064 1.00 196.32 ? 190 LYS A CD    1 
ATOM   1500 C  CE    . LYS A 1 190 ? 129.330 139.604 143.960 1.00 196.32 ? 190 LYS A CE    1 
ATOM   1501 N  NZ    . LYS A 1 190 ? 130.738 139.729 143.490 1.00 196.32 ? 190 LYS A NZ    1 
ATOM   1502 N  N     . LYS A 1 191 ? 127.449 140.667 148.963 1.00 201.74 ? 191 LYS A N     1 
ATOM   1503 C  CA    . LYS A 1 191 ? 128.031 140.404 150.276 1.00 201.74 ? 191 LYS A CA    1 
ATOM   1504 C  C     . LYS A 1 191 ? 126.954 140.065 151.300 1.00 201.74 ? 191 LYS A C     1 
ATOM   1505 O  O     . LYS A 1 191 ? 127.071 139.079 152.039 1.00 201.74 ? 191 LYS A O     1 
ATOM   1506 C  CB    . LYS A 1 191 ? 128.854 141.604 150.745 1.00 201.74 ? 191 LYS A CB    1 
ATOM   1507 C  CG    . LYS A 1 191 ? 129.981 142.007 149.809 1.00 201.74 ? 191 LYS A CG    1 
ATOM   1508 C  CD    . LYS A 1 191 ? 130.855 140.819 149.449 1.00 201.74 ? 191 LYS A CD    1 
ATOM   1509 C  CE    . LYS A 1 191 ? 131.422 140.963 148.048 1.00 201.74 ? 191 LYS A CE    1 
ATOM   1510 N  NZ    . LYS A 1 191 ? 130.353 140.913 147.015 1.00 201.74 ? 191 LYS A NZ    1 
ATOM   1511 N  N     . ILE A 1 192 ? 125.890 140.870 151.357 1.00 187.93 ? 192 ILE A N     1 
ATOM   1512 C  CA    . ILE A 1 192 ? 124.842 140.603 152.335 1.00 187.93 ? 192 ILE A CA    1 
ATOM   1513 C  C     . ILE A 1 192 ? 124.119 139.302 152.008 1.00 187.93 ? 192 ILE A C     1 
ATOM   1514 O  O     . ILE A 1 192 ? 123.722 138.563 152.920 1.00 187.93 ? 192 ILE A O     1 
ATOM   1515 C  CB    . ILE A 1 192 ? 123.869 141.795 152.441 1.00 187.93 ? 192 ILE A CB    1 
ATOM   1516 C  CG1   . ILE A 1 192 ? 123.073 141.984 151.149 1.00 187.93 ? 192 ILE A CG1   1 
ATOM   1517 C  CG2   . ILE A 1 192 ? 124.621 143.065 152.807 1.00 187.93 ? 192 ILE A CG2   1 
ATOM   1518 C  CD1   . ILE A 1 192 ? 121.838 142.838 151.313 1.00 187.93 ? 192 ILE A CD1   1 
ATOM   1519 N  N     . LYS A 1 193 ? 123.946 138.988 150.719 1.00 191.46 ? 193 LYS A N     1 
ATOM   1520 C  CA    . LYS A 1 193 ? 123.320 137.729 150.338 1.00 191.46 ? 193 LYS A CA    1 
ATOM   1521 C  C     . LYS A 1 193 ? 124.152 136.545 150.805 1.00 191.46 ? 193 LYS A C     1 
ATOM   1522 O  O     . LYS A 1 193 ? 123.620 135.577 151.360 1.00 191.46 ? 193 LYS A O     1 
ATOM   1523 C  CB    . LYS A 1 193 ? 123.118 137.687 148.823 1.00 191.46 ? 193 LYS A CB    1 
ATOM   1524 C  CG    . LYS A 1 193 ? 121.903 136.894 148.377 1.00 191.46 ? 193 LYS A CG    1 
ATOM   1525 C  CD    . LYS A 1 193 ? 121.940 136.619 146.885 1.00 191.46 ? 193 LYS A CD    1 
ATOM   1526 C  CE    . LYS A 1 193 ? 121.212 137.704 146.109 1.00 191.46 ? 193 LYS A CE    1 
ATOM   1527 N  NZ    . LYS A 1 193 ? 119.765 137.755 146.450 1.00 191.46 ? 193 LYS A NZ    1 
ATOM   1528 N  N     . GLU A 1 194 ? 125.470 136.615 150.606 1.00 189.12 ? 194 GLU A N     1 
ATOM   1529 C  CA    . GLU A 1 194 ? 126.346 135.550 151.081 1.00 189.12 ? 194 GLU A CA    1 
ATOM   1530 C  C     . GLU A 1 194 ? 126.284 135.427 152.597 1.00 189.12 ? 194 GLU A C     1 
ATOM   1531 O  O     . GLU A 1 194 ? 126.287 134.315 153.139 1.00 189.12 ? 194 GLU A O     1 
ATOM   1532 C  CB    . GLU A 1 194 ? 127.782 135.802 150.624 1.00 189.12 ? 194 GLU A CB    1 
ATOM   1533 C  CG    . GLU A 1 194 ? 128.053 135.413 149.184 1.00 189.12 ? 194 GLU A CG    1 
ATOM   1534 C  CD    . GLU A 1 194 ? 129.206 136.189 148.584 1.00 189.12 ? 194 GLU A CD    1 
ATOM   1535 O  OE1   . GLU A 1 194 ? 130.004 136.762 149.355 1.00 189.12 ? 194 GLU A OE1   1 
ATOM   1536 O  OE2   . GLU A 1 194 ? 129.318 136.224 147.341 1.00 189.12 ? 194 GLU A OE2   1 
ATOM   1537 N  N     . LEU A 1 195 ? 126.220 136.561 153.299 1.00 190.21 ? 195 LEU A N     1 
ATOM   1538 C  CA    . LEU A 1 195 ? 126.162 136.522 154.757 1.00 190.21 ? 195 LEU A CA    1 
ATOM   1539 C  C     . LEU A 1 195 ? 124.898 135.813 155.234 1.00 190.21 ? 195 LEU A C     1 
ATOM   1540 O  O     . LEU A 1 195 ? 124.964 134.880 156.047 1.00 190.21 ? 195 LEU A O     1 
ATOM   1541 C  CB    . LEU A 1 195 ? 126.236 137.944 155.320 1.00 190.21 ? 195 LEU A CB    1 
ATOM   1542 C  CG    . LEU A 1 195 ? 125.648 138.282 156.696 1.00 190.21 ? 195 LEU A CG    1 
ATOM   1543 C  CD1   . LEU A 1 195 ? 126.179 137.365 157.797 1.00 190.21 ? 195 LEU A CD1   1 
ATOM   1544 C  CD2   . LEU A 1 195 ? 125.909 139.740 157.042 1.00 190.21 ? 195 LEU A CD2   1 
ATOM   1545 N  N     . GLU A 1 196 ? 123.730 136.236 154.736 1.00 199.24 ? 196 GLU A N     1 
ATOM   1546 C  CA    . GLU A 1 196 ? 122.500 135.616 155.217 1.00 199.24 ? 196 GLU A CA    1 
ATOM   1547 C  C     . GLU A 1 196 ? 122.332 134.198 154.689 1.00 199.24 ? 196 GLU A C     1 
ATOM   1548 O  O     . GLU A 1 196 ? 121.562 133.423 155.266 1.00 199.24 ? 196 GLU A O     1 
ATOM   1549 C  CB    . GLU A 1 196 ? 121.264 136.455 154.866 1.00 199.24 ? 196 GLU A CB    1 
ATOM   1550 C  CG    . GLU A 1 196 ? 121.209 137.052 153.471 1.00 199.24 ? 196 GLU A CG    1 
ATOM   1551 C  CD    . GLU A 1 196 ? 120.645 136.098 152.435 1.00 199.24 ? 196 GLU A CD    1 
ATOM   1552 O  OE1   . GLU A 1 196 ? 120.602 136.468 151.245 1.00 199.24 ? 196 GLU A OE1   1 
ATOM   1553 O  OE2   . GLU A 1 196 ? 120.232 134.983 152.806 1.00 199.24 ? 196 GLU A OE2   1 
ATOM   1554 N  N     . ALA A 1 197 ? 123.033 133.838 153.611 1.00 191.68 ? 197 ALA A N     1 
ATOM   1555 C  CA    . ALA A 1 197 ? 123.048 132.446 153.182 1.00 191.68 ? 197 ALA A CA    1 
ATOM   1556 C  C     . ALA A 1 197 ? 123.887 131.593 154.123 1.00 191.68 ? 197 ALA A C     1 
ATOM   1557 O  O     . ALA A 1 197 ? 123.508 130.463 154.451 1.00 191.68 ? 197 ALA A O     1 
ATOM   1558 C  CB    . ALA A 1 197 ? 123.574 132.346 151.752 1.00 191.68 ? 197 ALA A CB    1 
ATOM   1559 N  N     . THR A 1 198 ? 125.032 132.118 154.562 1.00 179.32 ? 198 THR A N     1 
ATOM   1560 C  CA    . THR A 1 198 ? 125.893 131.368 155.470 1.00 179.32 ? 198 THR A CA    1 
ATOM   1561 C  C     . THR A 1 198 ? 125.233 131.185 156.831 1.00 179.32 ? 198 THR A C     1 
ATOM   1562 O  O     . THR A 1 198 ? 125.219 130.078 157.381 1.00 179.32 ? 198 THR A O     1 
ATOM   1563 C  CB    . THR A 1 198 ? 127.243 132.073 155.613 1.00 179.32 ? 198 THR A CB    1 
ATOM   1564 O  OG1   . THR A 1 198 ? 128.007 131.891 154.415 1.00 179.32 ? 198 THR A OG1   1 
ATOM   1565 C  CG2   . THR A 1 198 ? 128.020 131.508 156.793 1.00 179.32 ? 198 THR A CG2   1 
ATOM   1566 N  N     . LEU A 1 199 ? 124.671 132.257 157.390 1.00 165.73 ? 199 LEU A N     1 
ATOM   1567 C  CA    . LEU A 1 199 ? 124.083 132.155 158.721 1.00 165.73 ? 199 LEU A CA    1 
ATOM   1568 C  C     . LEU A 1 199 ? 122.716 131.486 158.729 1.00 165.73 ? 199 LEU A C     1 
ATOM   1569 O  O     . LEU A 1 199 ? 122.219 131.158 159.812 1.00 165.73 ? 199 LEU A O     1 
ATOM   1570 C  CB    . LEU A 1 199 ? 123.981 133.537 159.368 1.00 165.73 ? 199 LEU A CB    1 
ATOM   1571 C  CG    . LEU A 1 199 ? 125.244 133.956 160.120 1.00 165.73 ? 199 LEU A CG    1 
ATOM   1572 C  CD1   . LEU A 1 199 ? 125.103 135.348 160.713 1.00 165.73 ? 199 LEU A CD1   1 
ATOM   1573 C  CD2   . LEU A 1 199 ? 125.559 132.939 161.201 1.00 165.73 ? 199 LEU A CD2   1 
ATOM   1574 N  N     . ASN A 1 200 ? 122.105 131.272 157.561 1.00 185.48 ? 200 ASN A N     1 
ATOM   1575 C  CA    . ASN A 1 200 ? 120.794 130.630 157.457 1.00 185.48 ? 200 ASN A CA    1 
ATOM   1576 C  C     . ASN A 1 200 ? 119.753 131.346 158.316 1.00 185.48 ? 200 ASN A C     1 
ATOM   1577 O  O     . ASN A 1 200 ? 118.946 130.722 159.006 1.00 185.48 ? 200 ASN A O     1 
ATOM   1578 C  CB    . ASN A 1 200 ? 120.872 129.147 157.823 1.00 185.48 ? 200 ASN A CB    1 
ATOM   1579 C  CG    . ASN A 1 200 ? 119.750 128.335 157.209 1.00 185.48 ? 200 ASN A CG    1 
ATOM   1580 O  OD1   . ASN A 1 200 ? 118.742 128.883 156.765 1.00 185.48 ? 200 ASN A OD1   1 
ATOM   1581 N  ND2   . ASN A 1 200 ? 119.914 127.019 157.188 1.00 185.48 ? 200 ASN A ND2   1 
ATOM   1582 N  N     . SER A 1 201 ? 119.778 132.676 158.275 1.00 189.32 ? 201 SER A N     1 
ATOM   1583 C  CA    . SER A 1 201 ? 118.831 133.483 159.028 1.00 189.32 ? 201 SER A CA    1 
ATOM   1584 C  C     . SER A 1 201 ? 118.562 134.766 158.260 1.00 189.32 ? 201 SER A C     1 
ATOM   1585 O  O     . SER A 1 201 ? 119.333 135.163 157.383 1.00 189.32 ? 201 SER A O     1 
ATOM   1586 C  CB    . SER A 1 201 ? 119.347 133.792 160.440 1.00 189.32 ? 201 SER A CB    1 
ATOM   1587 O  OG    . SER A 1 201 ? 119.545 132.601 161.182 1.00 189.32 ? 201 SER A OG    1 
ATOM   1588 N  N     . ARG A 1 202 ? 117.452 135.413 158.601 1.00 209.96 ? 202 ARG A N     1 
ATOM   1589 C  CA    . ARG A 1 202 ? 117.002 136.618 157.917 1.00 209.96 ? 202 ARG A CA    1 
ATOM   1590 C  C     . ARG A 1 202 ? 117.314 137.836 158.776 1.00 209.96 ? 202 ARG A C     1 
ATOM   1591 O  O     . ARG A 1 202 ? 116.852 137.929 159.918 1.00 209.96 ? 202 ARG A O     1 
ATOM   1592 C  CB    . ARG A 1 202 ? 115.505 136.542 157.619 1.00 209.96 ? 202 ARG A CB    1 
ATOM   1593 C  CG    . ARG A 1 202 ? 114.941 137.777 156.939 1.00 209.96 ? 202 ARG A CG    1 
ATOM   1594 C  CD    . ARG A 1 202 ? 113.441 137.653 156.731 1.00 209.96 ? 202 ARG A CD    1 
ATOM   1595 N  NE    . ARG A 1 202 ? 112.867 138.869 156.168 1.00 209.96 ? 202 ARG A NE    1 
ATOM   1596 C  CZ    . ARG A 1 202 ? 112.519 139.932 156.880 1.00 209.96 ? 202 ARG A CZ    1 
ATOM   1597 N  NH1   . ARG A 1 202 ? 112.670 139.963 158.194 1.00 209.96 ? 202 ARG A NH1   1 
ATOM   1598 N  NH2   . ARG A 1 202 ? 112.009 140.991 156.258 1.00 209.96 ? 202 ARG A NH2   1 
ATOM   1599 N  N     . VAL A 1 203 ? 118.092 138.770 158.226 1.00 164.85 ? 203 VAL A N     1 
ATOM   1600 C  CA    . VAL A 1 203 ? 118.357 140.020 158.923 1.00 164.85 ? 203 VAL A CA    1 
ATOM   1601 C  C     . VAL A 1 203 ? 117.090 140.863 158.938 1.00 164.85 ? 203 VAL A C     1 
ATOM   1602 O  O     . VAL A 1 203 ? 116.355 140.937 157.943 1.00 164.85 ? 203 VAL A O     1 
ATOM   1603 C  CB    . VAL A 1 203 ? 119.531 140.767 158.266 1.00 164.85 ? 203 VAL A CB    1 
ATOM   1604 C  CG1   . VAL A 1 203 ? 119.238 141.056 156.802 1.00 164.85 ? 203 VAL A CG1   1 
ATOM   1605 C  CG2   . VAL A 1 203 ? 119.836 142.051 159.020 1.00 164.85 ? 203 VAL A CG2   1 
ATOM   1606 N  N     . VAL A 1 204 ? 116.814 141.489 160.077 1.00 175.68 ? 204 VAL A N     1 
ATOM   1607 C  CA    . VAL A 1 204 ? 115.569 142.218 160.284 1.00 175.68 ? 204 VAL A CA    1 
ATOM   1608 C  C     . VAL A 1 204 ? 115.886 143.631 160.745 1.00 175.68 ? 204 VAL A C     1 
ATOM   1609 O  O     . VAL A 1 204 ? 116.944 143.887 161.331 1.00 175.68 ? 204 VAL A O     1 
ATOM   1610 C  CB    . VAL A 1 204 ? 114.653 141.502 161.300 1.00 175.68 ? 204 VAL A CB    1 
ATOM   1611 C  CG1   . VAL A 1 204 ? 115.003 141.905 162.726 1.00 175.68 ? 204 VAL A CG1   1 
ATOM   1612 C  CG2   . VAL A 1 204 ? 113.194 141.799 161.000 1.00 175.68 ? 204 VAL A CG2   1 
ATOM   1613 N  N     . THR A 1 205 ? 114.974 144.555 160.450 1.00 192.16 ? 205 THR A N     1 
ATOM   1614 C  CA    . THR A 1 205 ? 115.043 145.929 160.925 1.00 192.16 ? 205 THR A CA    1 
ATOM   1615 C  C     . THR A 1 205 ? 113.633 146.396 161.250 1.00 192.16 ? 205 THR A C     1 
ATOM   1616 O  O     . THR A 1 205 ? 112.746 146.351 160.390 1.00 192.16 ? 205 THR A O     1 
ATOM   1617 C  CB    . THR A 1 205 ? 115.699 146.847 159.887 1.00 192.16 ? 205 THR A CB    1 
ATOM   1618 O  OG1   . THR A 1 205 ? 115.448 148.217 160.226 1.00 192.16 ? 205 THR A OG1   1 
ATOM   1619 C  CG2   . THR A 1 205 ? 115.163 146.558 158.494 1.00 192.16 ? 205 THR A CG2   1 
ATOM   1620 N  N     . ALA A 1 206 ? 113.421 146.826 162.489 1.00 214.13 ? 206 ALA A N     1 
ATOM   1621 C  CA    . ALA A 1 206 ? 112.096 147.237 162.920 1.00 214.13 ? 206 ALA A CA    1 
ATOM   1622 C  C     . ALA A 1 206 ? 111.712 148.570 162.295 1.00 214.13 ? 206 ALA A C     1 
ATOM   1623 O  O     . ALA A 1 206 ? 112.559 149.427 162.029 1.00 214.13 ? 206 ALA A O     1 
ATOM   1624 C  CB    . ALA A 1 206 ? 112.030 147.343 164.444 1.00 214.13 ? 206 ALA A CB    1 
ATOM   1625 N  N     . SER A 1 207 ? 110.411 148.736 162.051 1.00 239.97 ? 207 SER A N     1 
ATOM   1626 C  CA    . SER A 1 207 ? 109.913 150.029 161.603 1.00 239.97 ? 207 SER A CA    1 
ATOM   1627 C  C     . SER A 1 207 ? 110.011 151.071 162.709 1.00 239.97 ? 207 SER A C     1 
ATOM   1628 O  O     . SER A 1 207 ? 110.064 152.273 162.424 1.00 239.97 ? 207 SER A O     1 
ATOM   1629 C  CB    . SER A 1 207 ? 108.468 149.900 161.120 1.00 239.97 ? 207 SER A CB    1 
ATOM   1630 O  OG    . SER A 1 207 ? 107.615 149.487 162.172 1.00 239.97 ? 207 SER A OG    1 
ATOM   1631 N  N     . ASP A 1 208 ? 110.036 150.632 163.969 1.00 239.34 ? 208 ASP A N     1 
ATOM   1632 C  CA    . ASP A 1 208 ? 110.115 151.573 165.081 1.00 239.34 ? 208 ASP A CA    1 
ATOM   1633 C  C     . ASP A 1 208 ? 111.509 152.174 165.210 1.00 239.34 ? 208 ASP A C     1 
ATOM   1634 O  O     . ASP A 1 208 ? 111.649 153.383 165.426 1.00 239.34 ? 208 ASP A O     1 
ATOM   1635 C  CB    . ASP A 1 208 ? 109.706 150.883 166.381 1.00 239.34 ? 208 ASP A CB    1 
ATOM   1636 C  CG    . ASP A 1 208 ? 108.987 151.816 167.334 1.00 239.34 ? 208 ASP A CG    1 
ATOM   1637 O  OD1   . ASP A 1 208 ? 108.500 152.872 166.878 1.00 239.34 ? 208 ASP A OD1   1 
ATOM   1638 O  OD2   . ASP A 1 208 ? 108.908 151.494 168.538 1.00 239.34 ? 208 ASP A OD2   1 
ATOM   1639 N  N     . LEU A 1 209 ? 112.554 151.351 165.080 1.00 240.06 ? 209 LEU A N     1 
ATOM   1640 C  CA    . LEU A 1 209 ? 113.912 151.859 165.247 1.00 240.06 ? 209 LEU A CA    1 
ATOM   1641 C  C     . LEU A 1 209 ? 114.292 152.856 164.161 1.00 240.06 ? 209 LEU A C     1 
ATOM   1642 O  O     . LEU A 1 209 ? 115.160 153.705 164.389 1.00 240.06 ? 209 LEU A O     1 
ATOM   1643 C  CB    . LEU A 1 209 ? 114.916 150.699 165.285 1.00 240.06 ? 209 LEU A CB    1 
ATOM   1644 C  CG    . LEU A 1 209 ? 114.916 149.622 164.194 1.00 240.06 ? 209 LEU A CG    1 
ATOM   1645 C  CD1   . LEU A 1 209 ? 115.646 150.078 162.937 1.00 240.06 ? 209 LEU A CD1   1 
ATOM   1646 C  CD2   . LEU A 1 209 ? 115.526 148.332 164.723 1.00 240.06 ? 209 LEU A CD2   1 
ATOM   1647 N  N     . GLU A 1 210 ? 113.661 152.776 162.987 1.00 276.68 ? 210 GLU A N     1 
ATOM   1648 C  CA    . GLU A 1 210 ? 113.959 153.728 161.925 1.00 276.68 ? 210 GLU A CA    1 
ATOM   1649 C  C     . GLU A 1 210 ? 113.497 155.136 162.282 1.00 276.68 ? 210 GLU A C     1 
ATOM   1650 O  O     . GLU A 1 210 ? 114.118 156.117 161.855 1.00 276.68 ? 210 GLU A O     1 
ATOM   1651 C  CB    . GLU A 1 210 ? 113.311 153.269 160.617 1.00 276.68 ? 210 GLU A CB    1 
ATOM   1652 C  CG    . GLU A 1 210 ? 113.726 154.067 159.390 1.00 276.68 ? 210 GLU A CG    1 
ATOM   1653 C  CD    . GLU A 1 210 ? 112.796 155.233 159.109 1.00 276.68 ? 210 GLU A CD    1 
ATOM   1654 O  OE1   . GLU A 1 210 ? 111.624 155.176 159.539 1.00 276.68 ? 210 GLU A OE1   1 
ATOM   1655 O  OE2   . GLU A 1 210 ? 113.235 156.204 158.458 1.00 276.68 ? 210 GLU A OE2   1 
ATOM   1656 N  N     . GLU A 1 211 ? 112.426 155.257 163.063 1.00 248.06 ? 211 GLU A N     1 
ATOM   1657 C  CA    . GLU A 1 211 ? 111.805 156.543 163.363 1.00 248.06 ? 211 GLU A CA    1 
ATOM   1658 C  C     . GLU A 1 211 ? 112.023 156.884 164.833 1.00 248.06 ? 211 GLU A C     1 
ATOM   1659 O  O     . GLU A 1 211 ? 111.653 156.105 165.717 1.00 248.06 ? 211 GLU A O     1 
ATOM   1660 C  CB    . GLU A 1 211 ? 110.316 156.514 163.022 1.00 248.06 ? 211 GLU A CB    1 
ATOM   1661 C  CG    . GLU A 1 211 ? 109.593 155.265 163.507 1.00 248.06 ? 211 GLU A CG    1 
ATOM   1662 C  CD    . GLU A 1 211 ? 108.371 154.933 162.674 1.00 248.06 ? 211 GLU A CD    1 
ATOM   1663 O  OE1   . GLU A 1 211 ? 108.537 154.563 161.493 1.00 248.06 ? 211 GLU A OE1   1 
ATOM   1664 O  OE2   . GLU A 1 211 ? 107.245 155.041 163.203 1.00 248.06 ? 211 GLU A OE2   1 
ATOM   1665 N  N     . VAL A 1 212 ? 112.640 158.044 165.083 1.00 250.06 ? 212 VAL A N     1 
ATOM   1666 C  CA    . VAL A 1 212 ? 112.764 158.737 166.372 1.00 250.06 ? 212 VAL A CA    1 
ATOM   1667 C  C     . VAL A 1 212 ? 113.161 157.843 167.549 1.00 250.06 ? 212 VAL A C     1 
ATOM   1668 O  O     . VAL A 1 212 ? 113.879 158.291 168.451 1.00 250.06 ? 212 VAL A O     1 
ATOM   1669 C  CB    . VAL A 1 212 ? 111.471 159.520 166.707 1.00 250.06 ? 212 VAL A CB    1 
ATOM   1670 C  CG1   . VAL A 1 212 ? 110.255 158.608 166.883 1.00 250.06 ? 212 VAL A CG1   1 
ATOM   1671 C  CG2   . VAL A 1 212 ? 111.672 160.404 167.934 1.00 250.06 ? 212 VAL A CG2   1 
ATOM   1672 N  N     . ALA A 1 213 ? 112.714 156.584 167.553 1.00 240.29 ? 213 ALA A N     1 
ATOM   1673 C  CA    . ALA A 1 213 ? 112.887 155.726 168.722 1.00 240.29 ? 213 ALA A CA    1 
ATOM   1674 C  C     . ALA A 1 213 ? 114.359 155.577 169.093 1.00 240.29 ? 213 ALA A C     1 
ATOM   1675 O  O     . ALA A 1 213 ? 114.785 155.989 170.178 1.00 240.29 ? 213 ALA A O     1 
ATOM   1676 C  CB    . ALA A 1 213 ? 112.254 154.358 168.463 1.00 240.29 ? 213 ALA A CB    1 
ATOM   1677 N  N     . VAL A 1 214 ? 115.157 154.990 168.199 1.00 237.67 ? 214 VAL A N     1 
ATOM   1678 C  CA    . VAL A 1 214 ? 116.578 154.838 168.488 1.00 237.67 ? 214 VAL A CA    1 
ATOM   1679 C  C     . VAL A 1 214 ? 117.355 156.112 168.193 1.00 237.67 ? 214 VAL A C     1 
ATOM   1680 O  O     . VAL A 1 214 ? 118.488 156.261 168.667 1.00 237.67 ? 214 VAL A O     1 
ATOM   1681 C  CB    . VAL A 1 214 ? 117.180 153.660 167.700 1.00 237.67 ? 214 VAL A CB    1 
ATOM   1682 C  CG1   . VAL A 1 214 ? 117.617 154.105 166.312 1.00 237.67 ? 214 VAL A CG1   1 
ATOM   1683 C  CG2   . VAL A 1 214 ? 118.346 153.046 168.464 1.00 237.67 ? 214 VAL A CG2   1 
ATOM   1684 N  N     . GLN A 1 215 ? 116.774 157.042 167.430 1.00 221.69 ? 215 GLN A N     1 
ATOM   1685 C  CA    . GLN A 1 215 ? 117.486 158.264 167.073 1.00 221.69 ? 215 GLN A CA    1 
ATOM   1686 C  C     . GLN A 1 215 ? 117.835 159.081 168.310 1.00 221.69 ? 215 GLN A C     1 
ATOM   1687 O  O     . GLN A 1 215 ? 118.943 159.619 168.416 1.00 221.69 ? 215 GLN A O     1 
ATOM   1688 C  CB    . GLN A 1 215 ? 116.651 159.093 166.097 1.00 221.69 ? 215 GLN A CB    1 
ATOM   1689 C  CG    . GLN A 1 215 ? 116.668 158.590 164.657 1.00 221.69 ? 215 GLN A CG    1 
ATOM   1690 C  CD    . GLN A 1 215 ? 116.046 157.214 164.496 1.00 221.69 ? 215 GLN A CD    1 
ATOM   1691 O  OE1   . GLN A 1 215 ? 115.231 156.787 165.314 1.00 221.69 ? 215 GLN A OE1   1 
ATOM   1692 N  NE2   . GLN A 1 215 ? 116.431 156.512 163.435 1.00 221.69 ? 215 GLN A NE2   1 
ATOM   1693 N  N     . LYS A 1 216 ? 116.898 159.192 169.255 1.00 215.60 ? 216 LYS A N     1 
ATOM   1694 C  CA    . LYS A 1 216 ? 117.196 159.878 170.507 1.00 215.60 ? 216 LYS A CA    1 
ATOM   1695 C  C     . LYS A 1 216 ? 118.275 159.143 171.293 1.00 215.60 ? 216 LYS A C     1 
ATOM   1696 O  O     . LYS A 1 216 ? 119.185 159.768 171.848 1.00 215.60 ? 216 LYS A O     1 
ATOM   1697 C  CB    . LYS A 1 216 ? 115.926 160.016 171.346 1.00 215.60 ? 216 LYS A CB    1 
ATOM   1698 C  CG    . LYS A 1 216 ? 116.169 160.530 172.756 1.00 215.60 ? 216 LYS A CG    1 
ATOM   1699 C  CD    . LYS A 1 216 ? 115.177 159.939 173.745 1.00 215.60 ? 216 LYS A CD    1 
ATOM   1700 C  CE    . LYS A 1 216 ? 113.751 160.036 173.230 1.00 215.60 ? 216 LYS A CE    1 
ATOM   1701 N  NZ    . LYS A 1 216 ? 112.858 159.042 173.888 1.00 215.60 ? 216 LYS A NZ    1 
ATOM   1702 N  N     . TYR A 1 217 ? 118.190 157.814 171.347 1.00 211.67 ? 217 TYR A N     1 
ATOM   1703 C  CA    . TYR A 1 217 ? 119.152 157.036 172.119 1.00 211.67 ? 217 TYR A CA    1 
ATOM   1704 C  C     . TYR A 1 217 ? 120.506 156.953 171.422 1.00 211.67 ? 217 TYR A C     1 
ATOM   1705 O  O     . TYR A 1 217 ? 121.548 157.022 172.082 1.00 211.67 ? 217 TYR A O     1 
ATOM   1706 C  CB    . TYR A 1 217 ? 118.592 155.639 172.388 1.00 211.67 ? 217 TYR A CB    1 
ATOM   1707 C  CG    . TYR A 1 217 ? 117.256 155.659 173.096 1.00 211.67 ? 217 TYR A CG    1 
ATOM   1708 C  CD1   . TYR A 1 217 ? 117.021 156.530 174.152 1.00 211.67 ? 217 TYR A CD1   1 
ATOM   1709 C  CD2   . TYR A 1 217 ? 116.228 154.812 172.706 1.00 211.67 ? 217 TYR A CD2   1 
ATOM   1710 C  CE1   . TYR A 1 217 ? 115.803 156.555 174.801 1.00 211.67 ? 217 TYR A CE1   1 
ATOM   1711 C  CE2   . TYR A 1 217 ? 115.005 154.830 173.350 1.00 211.67 ? 217 TYR A CE2   1 
ATOM   1712 C  CZ    . TYR A 1 217 ? 114.799 155.704 174.396 1.00 211.67 ? 217 TYR A CZ    1 
ATOM   1713 O  OH    . TYR A 1 217 ? 113.584 155.726 175.041 1.00 211.67 ? 217 TYR A OH    1 
ATOM   1714 N  N     . ALA A 1 218 ? 120.513 156.803 170.101 1.00 220.58 ? 218 ALA A N     1 
ATOM   1715 C  CA    . ALA A 1 218 ? 121.769 156.787 169.368 1.00 220.58 ? 218 ALA A CA    1 
ATOM   1716 C  C     . ALA A 1 218 ? 122.362 158.191 169.292 1.00 220.58 ? 218 ALA A C     1 
ATOM   1717 O  O     . ALA A 1 218 ? 121.658 159.201 169.378 1.00 220.58 ? 218 ALA A O     1 
ATOM   1718 C  CB    . ALA A 1 218 ? 121.569 156.225 167.960 1.00 220.58 ? 218 ALA A CB    1 
ATOM   1719 N  N     . THR A 1 219 ? 123.682 158.247 169.131 1.00 188.02 ? 219 THR A N     1 
ATOM   1720 C  CA    . THR A 1 219 ? 124.408 159.505 169.055 1.00 188.02 ? 219 THR A CA    1 
ATOM   1721 C  C     . THR A 1 219 ? 125.242 159.545 167.783 1.00 188.02 ? 219 THR A C     1 
ATOM   1722 O  O     . THR A 1 219 ? 125.680 158.509 167.274 1.00 188.02 ? 219 THR A O     1 
ATOM   1723 C  CB    . THR A 1 219 ? 125.310 159.716 170.286 1.00 188.02 ? 219 THR A CB    1 
ATOM   1724 O  OG1   . THR A 1 219 ? 125.941 161.000 170.207 1.00 188.02 ? 219 THR A OG1   1 
ATOM   1725 C  CG2   . THR A 1 219 ? 126.376 158.632 170.368 1.00 188.02 ? 219 THR A CG2   1 
ATOM   1726 N  N     . LYS A 1 220 ? 125.444 160.755 167.264 1.00 190.19 ? 220 LYS A N     1 
ATOM   1727 C  CA    . LYS A 1 220 ? 126.249 160.969 166.073 1.00 190.19 ? 220 LYS A CA    1 
ATOM   1728 C  C     . LYS A 1 220 ? 127.249 162.087 166.348 1.00 190.19 ? 220 LYS A C     1 
ATOM   1729 O  O     . LYS A 1 220 ? 126.864 163.151 166.866 1.00 190.19 ? 220 LYS A O     1 
ATOM   1730 C  CB    . LYS A 1 220 ? 125.371 161.310 164.860 1.00 190.19 ? 220 LYS A CB    1 
ATOM   1731 C  CG    . LYS A 1 220 ? 124.399 162.455 165.088 1.00 190.19 ? 220 LYS A CG    1 
ATOM   1732 C  CD    . LYS A 1 220 ? 123.696 162.846 163.801 1.00 190.19 ? 220 LYS A CD    1 
ATOM   1733 C  CE    . LYS A 1 220 ? 122.661 163.928 164.049 1.00 190.19 ? 220 LYS A CE    1 
ATOM   1734 N  NZ    . LYS A 1 220 ? 123.280 165.161 164.611 1.00 190.19 ? 220 LYS A NZ    1 
ATOM   1735 N  N     . PRO A 1 221 ? 128.525 161.891 166.035 1.00 170.80 ? 221 PRO A N     1 
ATOM   1736 C  CA    . PRO A 1 221 ? 129.531 162.916 166.313 1.00 170.80 ? 221 PRO A CA    1 
ATOM   1737 C  C     . PRO A 1 221 ? 129.736 163.862 165.138 1.00 170.80 ? 221 PRO A C     1 
ATOM   1738 O  O     . PRO A 1 221 ? 129.263 163.635 164.022 1.00 170.80 ? 221 PRO A O     1 
ATOM   1739 C  CB    . PRO A 1 221 ? 130.793 162.083 166.564 1.00 170.80 ? 221 PRO A CB    1 
ATOM   1740 C  CG    . PRO A 1 221 ? 130.623 160.907 165.644 1.00 170.80 ? 221 PRO A CG    1 
ATOM   1741 C  CD    . PRO A 1 221 ? 129.131 160.657 165.504 1.00 170.80 ? 221 PRO A CD    1 
ATOM   1742 N  N     . LYS A 1 222 ? 130.458 164.942 165.416 1.00 168.89 ? 222 LYS A N     1 
ATOM   1743 C  CA    . LYS A 1 222 ? 130.847 165.893 164.386 1.00 168.89 ? 222 LYS A CA    1 
ATOM   1744 C  C     . LYS A 1 222 ? 132.247 165.573 163.878 1.00 168.89 ? 222 LYS A C     1 
ATOM   1745 O  O     . LYS A 1 222 ? 133.143 165.216 164.647 1.00 168.89 ? 222 LYS A O     1 
ATOM   1746 C  CB    . LYS A 1 222 ? 130.795 167.327 164.915 1.00 168.89 ? 222 LYS A CB    1 
ATOM   1747 C  CG    . LYS A 1 222 ? 131.406 167.517 166.292 1.00 168.89 ? 222 LYS A CG    1 
ATOM   1748 C  CD    . LYS A 1 222 ? 130.648 168.575 167.081 1.00 168.89 ? 222 LYS A CD    1 
ATOM   1749 C  CE    . LYS A 1 222 ? 131.254 168.786 168.458 1.00 168.89 ? 222 LYS A CE    1 
ATOM   1750 N  NZ    . LYS A 1 222 ? 130.739 167.801 169.447 1.00 168.89 ? 222 LYS A NZ    1 
ATOM   1751 N  N     . GLU A 1 223 ? 132.426 165.706 162.568 1.00 172.81 ? 223 GLU A N     1 
ATOM   1752 C  CA    . GLU A 1 223 ? 133.656 165.316 161.893 1.00 172.81 ? 223 GLU A CA    1 
ATOM   1753 C  C     . GLU A 1 223 ? 134.495 166.549 161.595 1.00 172.81 ? 223 GLU A C     1 
ATOM   1754 O  O     . GLU A 1 223 ? 133.976 167.558 161.104 1.00 172.81 ? 223 GLU A O     1 
ATOM   1755 C  CB    . GLU A 1 223 ? 133.348 164.562 160.597 1.00 172.81 ? 223 GLU A CB    1 
ATOM   1756 C  CG    . GLU A 1 223 ? 132.573 163.268 160.794 1.00 172.81 ? 223 GLU A CG    1 
ATOM   1757 C  CD    . GLU A 1 223 ? 131.073 163.485 160.860 1.00 172.81 ? 223 GLU A CD    1 
ATOM   1758 O  OE1   . GLU A 1 223 ? 130.639 164.656 160.866 1.00 172.81 ? 223 GLU A OE1   1 
ATOM   1759 O  OE2   . GLU A 1 223 ? 130.329 162.484 160.905 1.00 172.81 ? 223 GLU A OE2   1 
ATOM   1760 N  N     . ILE A 1 224 ? 135.790 166.465 161.893 1.00 149.17 ? 224 ILE A N     1 
ATOM   1761 C  CA    . ILE A 1 224 ? 136.738 167.541 161.635 1.00 149.17 ? 224 ILE A CA    1 
ATOM   1762 C  C     . ILE A 1 224 ? 137.926 166.961 160.880 1.00 149.17 ? 224 ILE A C     1 
ATOM   1763 O  O     . ILE A 1 224 ? 138.489 165.939 161.290 1.00 149.17 ? 224 ILE A O     1 
ATOM   1764 C  CB    . ILE A 1 224 ? 137.204 168.220 162.938 1.00 149.17 ? 224 ILE A CB    1 
ATOM   1765 C  CG1   . ILE A 1 224 ? 136.072 169.058 163.535 1.00 149.17 ? 224 ILE A CG1   1 
ATOM   1766 C  CG2   . ILE A 1 224 ? 138.432 169.081 162.686 1.00 149.17 ? 224 ILE A CG2   1 
ATOM   1767 C  CD1   . ILE A 1 224 ? 136.512 169.943 164.678 1.00 149.17 ? 224 ILE A CD1   1 
ATOM   1768 N  N     . ILE A 1 225 ? 138.304 167.609 159.783 1.00 143.04 ? 225 ILE A N     1 
ATOM   1769 C  CA    . ILE A 1 225 ? 139.443 167.201 158.970 1.00 143.04 ? 225 ILE A CA    1 
ATOM   1770 C  C     . ILE A 1 225 ? 140.565 168.201 159.204 1.00 143.04 ? 225 ILE A C     1 
ATOM   1771 O  O     . ILE A 1 225 ? 140.387 169.406 158.989 1.00 143.04 ? 225 ILE A O     1 
ATOM   1772 C  CB    . ILE A 1 225 ? 139.075 167.116 157.482 1.00 143.04 ? 225 ILE A CB    1 
ATOM   1773 C  CG1   . ILE A 1 225 ? 138.265 165.848 157.207 1.00 143.04 ? 225 ILE A CG1   1 
ATOM   1774 C  CG2   . ILE A 1 225 ? 140.325 167.157 156.619 1.00 143.04 ? 225 ILE A CG2   1 
ATOM   1775 C  CD1   . ILE A 1 225 ? 138.129 165.513 155.738 1.00 143.04 ? 225 ILE A CD1   1 
ATOM   1776 N  N     . VAL A 1 226 ? 141.718 167.705 159.645 1.00 145.70 ? 226 VAL A N     1 
ATOM   1777 C  CA    . VAL A 1 226 ? 142.877 168.535 159.951 1.00 145.70 ? 226 VAL A CA    1 
ATOM   1778 C  C     . VAL A 1 226 ? 144.007 168.148 159.010 1.00 145.70 ? 226 VAL A C     1 
ATOM   1779 O  O     . VAL A 1 226 ? 144.415 166.982 158.967 1.00 145.70 ? 226 VAL A O     1 
ATOM   1780 C  CB    . VAL A 1 226 ? 143.314 168.384 161.419 1.00 145.70 ? 226 VAL A CB    1 
ATOM   1781 C  CG1   . VAL A 1 226 ? 144.334 169.449 161.779 1.00 145.70 ? 226 VAL A CG1   1 
ATOM   1782 C  CG2   . VAL A 1 226 ? 142.107 168.462 162.341 1.00 145.70 ? 226 VAL A CG2   1 
ATOM   1783 N  N     . SER A 1 227 ? 144.519 169.128 158.273 1.00 156.29 ? 227 SER A N     1 
ATOM   1784 C  CA    . SER A 1 227 ? 145.576 168.905 157.297 1.00 156.29 ? 227 SER A CA    1 
ATOM   1785 C  C     . SER A 1 227 ? 146.933 169.217 157.912 1.00 156.29 ? 227 SER A C     1 
ATOM   1786 O  O     . SER A 1 227 ? 147.060 170.126 158.737 1.00 156.29 ? 227 SER A O     1 
ATOM   1787 C  CB    . SER A 1 227 ? 145.357 169.767 156.054 1.00 156.29 ? 227 SER A CB    1 
ATOM   1788 O  OG    . SER A 1 227 ? 145.376 171.145 156.381 1.00 156.29 ? 227 SER A OG    1 
ATOM   1789 N  N     . TYR A 1 228 ? 147.945 168.453 157.505 1.00 145.20 ? 228 TYR A N     1 
ATOM   1790 C  CA    . TYR A 1 228 ? 149.304 168.641 157.988 1.00 145.20 ? 228 TYR A CA    1 
ATOM   1791 C  C     . TYR A 1 228 ? 150.280 168.224 156.900 1.00 145.20 ? 228 TYR A C     1 
ATOM   1792 O  O     . TYR A 1 228 ? 149.949 167.440 156.007 1.00 145.20 ? 228 TYR A O     1 
ATOM   1793 C  CB    . TYR A 1 228 ? 149.565 167.837 159.268 1.00 145.20 ? 228 TYR A CB    1 
ATOM   1794 C  CG    . TYR A 1 228 ? 149.950 166.401 159.010 1.00 145.20 ? 228 TYR A CG    1 
ATOM   1795 C  CD1   . TYR A 1 228 ? 148.995 165.464 158.640 1.00 145.20 ? 228 TYR A CD1   1 
ATOM   1796 C  CD2   . TYR A 1 228 ? 151.265 165.979 159.140 1.00 145.20 ? 228 TYR A CD2   1 
ATOM   1797 C  CE1   . TYR A 1 228 ? 149.341 164.151 158.401 1.00 145.20 ? 228 TYR A CE1   1 
ATOM   1798 C  CE2   . TYR A 1 228 ? 151.620 164.668 158.903 1.00 145.20 ? 228 TYR A CE2   1 
ATOM   1799 C  CZ    . TYR A 1 228 ? 150.654 163.759 158.535 1.00 145.20 ? 228 TYR A CZ    1 
ATOM   1800 O  OH    . TYR A 1 228 ? 151.004 162.449 158.300 1.00 145.20 ? 228 TYR A OH    1 
ATOM   1801 N  N     . ASN A 1 229 ? 151.496 168.754 156.988 1.00 170.79 ? 229 ASN A N     1 
ATOM   1802 C  CA    . ASN A 1 229 ? 152.554 168.466 156.031 1.00 170.79 ? 229 ASN A CA    1 
ATOM   1803 C  C     . ASN A 1 229 ? 153.731 167.819 156.746 1.00 170.79 ? 229 ASN A C     1 
ATOM   1804 O  O     . ASN A 1 229 ? 154.090 168.218 157.859 1.00 170.79 ? 229 ASN A O     1 
ATOM   1805 C  CB    . ASN A 1 229 ? 153.005 169.737 155.301 1.00 170.79 ? 229 ASN A CB    1 
ATOM   1806 C  CG    . ASN A 1 229 ? 153.577 170.781 156.241 1.00 170.79 ? 229 ASN A CG    1 
ATOM   1807 O  OD1   . ASN A 1 229 ? 154.726 170.686 156.672 1.00 170.79 ? 229 ASN A OD1   1 
ATOM   1808 N  ND2   . ASN A 1 229 ? 152.772 171.787 156.566 1.00 170.79 ? 229 ASN A ND2   1 
ATOM   1809 N  N     . SER A 1 230 ? 154.324 166.813 156.104 1.00 196.80 ? 230 SER A N     1 
ATOM   1810 C  CA    . SER A 1 230 ? 155.447 166.084 156.673 1.00 196.80 ? 230 SER A CA    1 
ATOM   1811 C  C     . SER A 1 230 ? 156.769 166.361 155.973 1.00 196.80 ? 230 SER A C     1 
ATOM   1812 O  O     . SER A 1 230 ? 157.820 165.984 156.504 1.00 196.80 ? 230 SER A O     1 
ATOM   1813 C  CB    . SER A 1 230 ? 155.170 164.573 156.641 1.00 196.80 ? 230 SER A CB    1 
ATOM   1814 O  OG    . SER A 1 230 ? 155.423 164.036 155.355 1.00 196.80 ? 230 SER A OG    1 
ATOM   1815 N  N     . ASP A 1 231 ? 156.749 166.999 154.801 1.00 210.02 ? 231 ASP A N     1 
ATOM   1816 C  CA    . ASP A 1 231 ? 157.994 167.289 154.096 1.00 210.02 ? 231 ASP A CA    1 
ATOM   1817 C  C     . ASP A 1 231 ? 158.860 168.266 154.880 1.00 210.02 ? 231 ASP A C     1 
ATOM   1818 O  O     . ASP A 1 231 ? 160.089 168.129 154.912 1.00 210.02 ? 231 ASP A O     1 
ATOM   1819 C  CB    . ASP A 1 231 ? 157.688 167.830 152.699 1.00 210.02 ? 231 ASP A CB    1 
ATOM   1820 C  CG    . ASP A 1 231 ? 157.072 169.214 152.729 1.00 210.02 ? 231 ASP A CG    1 
ATOM   1821 O  OD1   . ASP A 1 231 ? 156.137 169.432 153.528 1.00 210.02 ? 231 ASP A OD1   1 
ATOM   1822 O  OD2   . ASP A 1 231 ? 157.520 170.083 151.953 1.00 210.02 ? 231 ASP A OD2   1 
ATOM   1823 N  N     . ARG A 1 232 ? 158.242 169.257 155.516 1.00 239.28 ? 232 ARG A N     1 
ATOM   1824 C  CA    . ARG A 1 232 ? 158.991 170.226 156.305 1.00 239.28 ? 232 ARG A CA    1 
ATOM   1825 C  C     . ARG A 1 232 ? 159.442 169.608 157.622 1.00 239.28 ? 232 ARG A C     1 
ATOM   1826 O  O     . ARG A 1 232 ? 158.665 168.933 158.304 1.00 239.28 ? 232 ARG A O     1 
ATOM   1827 C  CB    . ARG A 1 232 ? 158.141 171.468 156.563 1.00 239.28 ? 232 ARG A CB    1 
ATOM   1828 C  CG    . ARG A 1 232 ? 157.838 172.278 155.314 1.00 239.28 ? 232 ARG A CG    1 
ATOM   1829 C  CD    . ARG A 1 232 ? 159.108 172.894 154.750 1.00 239.28 ? 232 ARG A CD    1 
ATOM   1830 N  NE    . ARG A 1 232 ? 159.032 173.094 153.308 1.00 239.28 ? 232 ARG A NE    1 
ATOM   1831 C  CZ    . ARG A 1 232 ? 159.579 172.286 152.411 1.00 239.28 ? 232 ARG A CZ    1 
ATOM   1832 N  NH1   . ARG A 1 232 ? 160.251 171.205 152.773 1.00 239.28 ? 232 ARG A NH1   1 
ATOM   1833 N  NH2   . ARG A 1 232 ? 159.446 172.568 151.118 1.00 239.28 ? 232 ARG A NH2   1 
ATOM   1834 N  N     . LYS A 1 233 ? 160.703 169.840 157.975 1.00 223.12 ? 233 LYS A N     1 
ATOM   1835 C  CA    . LYS A 1 233 ? 161.264 169.334 159.219 1.00 223.12 ? 233 LYS A CA    1 
ATOM   1836 C  C     . LYS A 1 233 ? 162.478 170.180 159.573 1.00 223.12 ? 233 LYS A C     1 
ATOM   1837 O  O     . LYS A 1 233 ? 162.969 170.963 158.756 1.00 223.12 ? 233 LYS A O     1 
ATOM   1838 C  CB    . LYS A 1 233 ? 161.643 167.852 159.107 1.00 223.12 ? 233 LYS A CB    1 
ATOM   1839 C  CG    . LYS A 1 233 ? 161.581 167.092 160.424 1.00 223.12 ? 233 LYS A CG    1 
ATOM   1840 C  CD    . LYS A 1 233 ? 161.275 165.620 160.200 1.00 223.12 ? 233 LYS A CD    1 
ATOM   1841 C  CE    . LYS A 1 233 ? 162.536 164.841 159.867 1.00 223.12 ? 233 LYS A CE    1 
ATOM   1842 N  NZ    . LYS A 1 233 ? 162.659 163.603 160.682 1.00 223.12 ? 233 LYS A NZ    1 
ATOM   1843 N  N     . SER A 1 234 ? 162.947 170.018 160.810 1.00 228.22 ? 234 SER A N     1 
ATOM   1844 C  CA    . SER A 1 234 ? 164.119 170.753 161.264 1.00 228.22 ? 234 SER A CA    1 
ATOM   1845 C  C     . SER A 1 234 ? 165.326 170.421 160.395 1.00 228.22 ? 234 SER A C     1 
ATOM   1846 O  O     . SER A 1 234 ? 165.537 169.270 160.006 1.00 228.22 ? 234 SER A O     1 
ATOM   1847 C  CB    . SER A 1 234 ? 164.415 170.425 162.728 1.00 228.22 ? 234 SER A CB    1 
ATOM   1848 O  OG    . SER A 1 234 ? 163.370 170.872 163.573 1.00 228.22 ? 234 SER A OG    1 
ATOM   1849 N  N     . ASP A 1 235 ? 166.119 171.451 160.084 1.00 224.96 ? 235 ASP A N     1 
ATOM   1850 C  CA    . ASP A 1 235 ? 167.294 171.258 159.239 1.00 224.96 ? 235 ASP A CA    1 
ATOM   1851 C  C     . ASP A 1 235 ? 168.279 170.294 159.885 1.00 224.96 ? 235 ASP A C     1 
ATOM   1852 O  O     . ASP A 1 235 ? 168.872 169.446 159.205 1.00 224.96 ? 235 ASP A O     1 
ATOM   1853 C  CB    . ASP A 1 235 ? 167.962 172.602 158.958 1.00 224.96 ? 235 ASP A CB    1 
ATOM   1854 C  CG    . ASP A 1 235 ? 167.060 173.552 158.198 1.00 224.96 ? 235 ASP A CG    1 
ATOM   1855 O  OD1   . ASP A 1 235 ? 165.924 173.155 157.865 1.00 224.96 ? 235 ASP A OD1   1 
ATOM   1856 O  OD2   . ASP A 1 235 ? 167.485 174.697 157.938 1.00 224.96 ? 235 ASP A OD2   1 
ATOM   1857 N  N     . THR A 1 236 ? 168.467 170.412 161.200 1.00 223.19 ? 236 THR A N     1 
ATOM   1858 C  CA    . THR A 1 236 ? 169.302 169.457 161.917 1.00 223.19 ? 236 THR A CA    1 
ATOM   1859 C  C     . THR A 1 236 ? 168.759 168.043 161.765 1.00 223.19 ? 236 THR A C     1 
ATOM   1860 O  O     . THR A 1 236 ? 169.524 167.099 161.540 1.00 223.19 ? 236 THR A O     1 
ATOM   1861 C  CB    . THR A 1 236 ? 169.387 169.839 163.394 1.00 223.19 ? 236 THR A CB    1 
ATOM   1862 O  OG1   . THR A 1 236 ? 168.116 169.619 164.016 1.00 223.19 ? 236 THR A OG1   1 
ATOM   1863 C  CG2   . THR A 1 236 ? 169.767 171.304 163.541 1.00 223.19 ? 236 THR A CG2   1 
ATOM   1864 N  N     . SER A 1 237 ? 167.439 167.882 161.874 1.00 228.56 ? 237 SER A N     1 
ATOM   1865 C  CA    . SER A 1 237 ? 166.837 166.562 161.708 1.00 228.56 ? 237 SER A CA    1 
ATOM   1866 C  C     . SER A 1 237 ? 167.095 166.010 160.313 1.00 228.56 ? 237 SER A C     1 
ATOM   1867 O  O     . SER A 1 237 ? 167.387 164.820 160.154 1.00 228.56 ? 237 SER A O     1 
ATOM   1868 C  CB    . SER A 1 237 ? 165.337 166.628 161.992 1.00 228.56 ? 237 SER A CB    1 
ATOM   1869 O  OG    . SER A 1 237 ? 165.080 167.269 163.229 1.00 228.56 ? 237 SER A OG    1 
ATOM   1870 N  N     . GLU A 1 238 ? 166.990 166.859 159.287 1.00 221.73 ? 238 GLU A N     1 
ATOM   1871 C  CA    . GLU A 1 238 ? 167.293 166.414 157.931 1.00 221.73 ? 238 GLU A CA    1 
ATOM   1872 C  C     . GLU A 1 238 ? 168.753 166.000 157.803 1.00 221.73 ? 238 GLU A C     1 
ATOM   1873 O  O     . GLU A 1 238 ? 169.077 165.034 157.100 1.00 221.73 ? 238 GLU A O     1 
ATOM   1874 C  CB    . GLU A 1 238 ? 166.951 167.516 156.929 1.00 221.73 ? 238 GLU A CB    1 
ATOM   1875 C  CG    . GLU A 1 238 ? 165.495 167.950 156.970 1.00 221.73 ? 238 GLU A CG    1 
ATOM   1876 C  CD    . GLU A 1 238 ? 165.290 169.362 156.461 1.00 221.73 ? 238 GLU A CD    1 
ATOM   1877 O  OE1   . GLU A 1 238 ? 166.284 170.111 156.364 1.00 221.73 ? 238 GLU A OE1   1 
ATOM   1878 O  OE2   . GLU A 1 238 ? 164.133 169.725 156.161 1.00 221.73 ? 238 GLU A OE2   1 
ATOM   1879 N  N     . VAL A 1 239 ? 169.649 166.719 158.482 1.00 211.48 ? 239 VAL A N     1 
ATOM   1880 C  CA    . VAL A 1 239 ? 171.055 166.325 158.503 1.00 211.48 ? 239 VAL A CA    1 
ATOM   1881 C  C     . VAL A 1 239 ? 171.206 164.939 159.120 1.00 211.48 ? 239 VAL A C     1 
ATOM   1882 O  O     . VAL A 1 239 ? 171.967 164.099 158.621 1.00 211.48 ? 239 VAL A O     1 
ATOM   1883 C  CB    . VAL A 1 239 ? 171.889 167.381 159.252 1.00 211.48 ? 239 VAL A CB    1 
ATOM   1884 C  CG1   . VAL A 1 239 ? 173.194 166.784 159.754 1.00 211.48 ? 239 VAL A CG1   1 
ATOM   1885 C  CG2   . VAL A 1 239 ? 172.155 168.579 158.352 1.00 211.48 ? 239 VAL A CG2   1 
ATOM   1886 N  N     . ILE A 1 240 ? 170.480 164.676 160.210 1.00 226.60 ? 240 ILE A N     1 
ATOM   1887 C  CA    . ILE A 1 240 ? 170.535 163.348 160.824 1.00 226.60 ? 240 ILE A CA    1 
ATOM   1888 C  C     . ILE A 1 240 ? 170.023 162.286 159.861 1.00 226.60 ? 240 ILE A C     1 
ATOM   1889 O  O     . ILE A 1 240 ? 170.591 161.193 159.771 1.00 226.60 ? 240 ILE A O     1 
ATOM   1890 C  CB    . ILE A 1 240 ? 169.765 163.304 162.160 1.00 226.60 ? 240 ILE A CB    1 
ATOM   1891 C  CG1   . ILE A 1 240 ? 169.956 164.584 162.969 1.00 226.60 ? 240 ILE A CG1   1 
ATOM   1892 C  CG2   . ILE A 1 240 ? 170.194 162.095 162.978 1.00 226.60 ? 240 ILE A CG2   1 
ATOM   1893 C  CD1   . ILE A 1 240 ? 171.403 164.915 163.260 1.00 226.60 ? 240 ILE A CD1   1 
ATOM   1894 N  N     . GLU A 1 241 ? 168.929 162.571 159.148 1.00 228.70 ? 241 GLU A N     1 
ATOM   1895 C  CA    . GLU A 1 241 ? 168.422 161.586 158.192 1.00 228.70 ? 241 GLU A CA    1 
ATOM   1896 C  C     . GLU A 1 241 ? 169.443 161.308 157.098 1.00 228.70 ? 241 GLU A C     1 
ATOM   1897 O  O     . GLU A 1 241 ? 169.615 160.157 156.681 1.00 228.70 ? 241 GLU A O     1 
ATOM   1898 C  CB    . GLU A 1 241 ? 167.089 162.026 157.580 1.00 228.70 ? 241 GLU A CB    1 
ATOM   1899 C  CG    . GLU A 1 241 ? 166.110 162.673 158.536 1.00 228.70 ? 241 GLU A CG    1 
ATOM   1900 C  CD    . GLU A 1 241 ? 164.891 163.235 157.830 1.00 228.70 ? 241 GLU A CD    1 
ATOM   1901 O  OE1   . GLU A 1 241 ? 164.859 164.453 157.561 1.00 228.70 ? 241 GLU A OE1   1 
ATOM   1902 O  OE2   . GLU A 1 241 ? 163.958 162.455 157.545 1.00 228.70 ? 241 GLU A OE2   1 
ATOM   1903 N  N     . ASN A 1 242 ? 170.137 162.345 156.626 1.00 233.25 ? 242 ASN A N     1 
ATOM   1904 C  CA    . ASN A 1 242 ? 171.209 162.128 155.657 1.00 233.25 ? 242 ASN A CA    1 
ATOM   1905 C  C     . ASN A 1 242 ? 172.312 161.256 156.246 1.00 233.25 ? 242 ASN A C     1 
ATOM   1906 O  O     . ASN A 1 242 ? 172.855 160.374 155.565 1.00 233.25 ? 242 ASN A O     1 
ATOM   1907 C  CB    . ASN A 1 242 ? 171.774 163.469 155.192 1.00 233.25 ? 242 ASN A CB    1 
ATOM   1908 C  CG    . ASN A 1 242 ? 170.701 164.407 154.679 1.00 233.25 ? 242 ASN A CG    1 
ATOM   1909 O  OD1   . ASN A 1 242 ? 169.671 163.970 154.166 1.00 233.25 ? 242 ASN A OD1   1 
ATOM   1910 N  ND2   . ASN A 1 242 ? 170.934 165.707 154.821 1.00 233.25 ? 242 ASN A ND2   1 
ATOM   1911 N  N     . ILE A 1 243 ? 172.656 161.490 157.515 1.00 229.73 ? 243 ILE A N     1 
ATOM   1912 C  CA    . ILE A 1 243 ? 173.695 160.696 158.166 1.00 229.73 ? 243 ILE A CA    1 
ATOM   1913 C  C     . ILE A 1 243 ? 173.284 159.230 158.242 1.00 229.73 ? 243 ILE A C     1 
ATOM   1914 O  O     . ILE A 1 243 ? 174.090 158.329 157.982 1.00 229.73 ? 243 ILE A O     1 
ATOM   1915 C  CB    . ILE A 1 243 ? 174.012 161.270 159.559 1.00 229.73 ? 243 ILE A CB    1 
ATOM   1916 C  CG1   . ILE A 1 243 ? 174.688 162.635 159.432 1.00 229.73 ? 243 ILE A CG1   1 
ATOM   1917 C  CG2   . ILE A 1 243 ? 174.890 160.311 160.348 1.00 229.73 ? 243 ILE A CG2   1 
ATOM   1918 C  CD1   . ILE A 1 243 ? 174.552 163.496 160.666 1.00 229.73 ? 243 ILE A CD1   1 
ATOM   1919 N  N     . ILE A 1 244 ? 172.029 158.966 158.605 1.00 238.61 ? 244 ILE A N     1 
ATOM   1920 C  CA    . ILE A 1 244 ? 171.568 157.580 158.678 1.00 238.61 ? 244 ILE A CA    1 
ATOM   1921 C  C     . ILE A 1 244 ? 171.466 156.967 157.289 1.00 238.61 ? 244 ILE A C     1 
ATOM   1922 O  O     . ILE A 1 244 ? 171.636 155.756 157.124 1.00 238.61 ? 244 ILE A O     1 
ATOM   1923 C  CB    . ILE A 1 244 ? 170.240 157.467 159.449 1.00 238.61 ? 244 ILE A CB    1 
ATOM   1924 C  CG1   . ILE A 1 244 ? 170.247 158.369 160.678 1.00 238.61 ? 244 ILE A CG1   1 
ATOM   1925 C  CG2   . ILE A 1 244 ? 169.981 156.024 159.856 1.00 238.61 ? 244 ILE A CG2   1 
ATOM   1926 C  CD1   . ILE A 1 244 ? 168.878 158.824 161.094 1.00 238.61 ? 244 ILE A CD1   1 
ATOM   1927 N  N     . ASN A 1 245 ? 171.175 157.776 156.268 1.00 245.13 ? 245 ASN A N     1 
ATOM   1928 C  CA    . ASN A 1 245 ? 171.234 157.258 154.904 1.00 245.13 ? 245 ASN A CA    1 
ATOM   1929 C  C     . ASN A 1 245 ? 172.645 156.805 154.557 1.00 245.13 ? 245 ASN A C     1 
ATOM   1930 O  O     . ASN A 1 245 ? 172.840 155.723 153.988 1.00 245.13 ? 245 ASN A O     1 
ATOM   1931 C  CB    . ASN A 1 245 ? 170.744 158.309 153.908 1.00 245.13 ? 245 ASN A CB    1 
ATOM   1932 C  CG    . ASN A 1 245 ? 169.238 158.478 153.931 1.00 245.13 ? 245 ASN A CG    1 
ATOM   1933 O  OD1   . ASN A 1 245 ? 168.726 159.571 154.169 1.00 245.13 ? 245 ASN A OD1   1 
ATOM   1934 N  ND2   . ASN A 1 245 ? 168.518 157.390 153.685 1.00 245.13 ? 245 ASN A ND2   1 
ATOM   1935 N  N     . GLN A 1 246 ? 173.646 157.611 154.916 1.00 241.12 ? 246 GLN A N     1 
ATOM   1936 C  CA    . GLN A 1 246 ? 175.032 157.203 154.705 1.00 241.12 ? 246 GLN A CA    1 
ATOM   1937 C  C     . GLN A 1 246 ? 175.356 155.937 155.489 1.00 241.12 ? 246 GLN A C     1 
ATOM   1938 O  O     . GLN A 1 246 ? 176.039 155.037 154.984 1.00 241.12 ? 246 GLN A O     1 
ATOM   1939 C  CB    . GLN A 1 246 ? 175.981 158.334 155.101 1.00 241.12 ? 246 GLN A CB    1 
ATOM   1940 C  CG    . GLN A 1 246 ? 175.752 159.634 154.351 1.00 241.12 ? 246 GLN A CG    1 
ATOM   1941 C  CD    . GLN A 1 246 ? 175.847 160.848 155.254 1.00 241.12 ? 246 GLN A CD    1 
ATOM   1942 O  OE1   . GLN A 1 246 ? 176.508 160.814 156.292 1.00 241.12 ? 246 GLN A OE1   1 
ATOM   1943 N  NE2   . GLN A 1 246 ? 175.180 161.929 154.865 1.00 241.12 ? 246 GLN A NE2   1 
ATOM   1944 N  N     . ALA A 1 247 ? 174.868 155.850 156.728 1.00 239.29 ? 247 ALA A N     1 
ATOM   1945 C  CA    . ALA A 1 247 ? 175.134 154.680 157.559 1.00 239.29 ? 247 ALA A CA    1 
ATOM   1946 C  C     . ALA A 1 247 ? 174.508 153.422 156.969 1.00 239.29 ? 247 ALA A C     1 
ATOM   1947 O  O     . ALA A 1 247 ? 175.128 152.354 156.967 1.00 239.29 ? 247 ALA A O     1 
ATOM   1948 C  CB    . ALA A 1 247 ? 174.624 154.919 158.979 1.00 239.29 ? 247 ALA A CB    1 
ATOM   1949 N  N     . LEU A 1 248 ? 173.273 153.524 156.473 1.00 245.12 ? 248 LEU A N     1 
ATOM   1950 C  CA    . LEU A 1 248 ? 172.622 152.357 155.886 1.00 245.12 ? 248 LEU A CA    1 
ATOM   1951 C  C     . LEU A 1 248 ? 173.288 151.961 154.577 1.00 245.12 ? 248 LEU A C     1 
ATOM   1952 O  O     . LEU A 1 248 ? 173.372 150.771 154.253 1.00 245.12 ? 248 LEU A O     1 
ATOM   1953 C  CB    . LEU A 1 248 ? 171.125 152.618 155.686 1.00 245.12 ? 248 LEU A CB    1 
ATOM   1954 C  CG    . LEU A 1 248 ? 170.596 153.605 154.642 1.00 245.12 ? 248 LEU A CG    1 
ATOM   1955 C  CD1   . LEU A 1 248 ? 170.389 152.940 153.288 1.00 245.12 ? 248 LEU A CD1   1 
ATOM   1956 C  CD2   . LEU A 1 248 ? 169.297 154.225 155.130 1.00 245.12 ? 248 LEU A CD2   1 
ATOM   1957 N  N     . GLU A 1 249 ? 173.774 152.941 153.809 1.00 275.11 ? 249 GLU A N     1 
ATOM   1958 C  CA    . GLU A 1 249 ? 174.564 152.611 152.627 1.00 275.11 ? 249 GLU A CA    1 
ATOM   1959 C  C     . GLU A 1 249 ? 175.834 151.862 153.012 1.00 275.11 ? 249 GLU A C     1 
ATOM   1960 O  O     . GLU A 1 249 ? 176.207 150.877 152.362 1.00 275.11 ? 249 GLU A O     1 
ATOM   1961 C  CB    . GLU A 1 249 ? 174.899 153.882 151.847 1.00 275.11 ? 249 GLU A CB    1 
ATOM   1962 C  CG    . GLU A 1 249 ? 173.694 154.548 151.204 1.00 275.11 ? 249 GLU A CG    1 
ATOM   1963 C  CD    . GLU A 1 249 ? 173.944 156.004 150.865 1.00 275.11 ? 249 GLU A CD    1 
ATOM   1964 O  OE1   . GLU A 1 249 ? 174.964 156.556 151.325 1.00 275.11 ? 249 GLU A OE1   1 
ATOM   1965 O  OE2   . GLU A 1 249 ? 173.118 156.596 150.140 1.00 275.11 ? 249 GLU A OE2   1 
ATOM   1966 N  N     . GLN A 1 250 ? 176.507 152.312 154.073 1.00 265.73 ? 250 GLN A N     1 
ATOM   1967 C  CA    . GLN A 1 250 ? 177.706 151.627 154.547 1.00 265.73 ? 250 GLN A CA    1 
ATOM   1968 C  C     . GLN A 1 250 ? 177.387 150.201 154.983 1.00 265.73 ? 250 GLN A C     1 
ATOM   1969 O  O     . GLN A 1 250 ? 178.130 149.262 154.676 1.00 265.73 ? 250 GLN A O     1 
ATOM   1970 C  CB    . GLN A 1 250 ? 178.334 152.414 155.696 1.00 265.73 ? 250 GLN A CB    1 
ATOM   1971 C  CG    . GLN A 1 250 ? 179.707 151.921 156.115 1.00 265.73 ? 250 GLN A CG    1 
ATOM   1972 C  CD    . GLN A 1 250 ? 180.365 152.837 157.127 1.00 265.73 ? 250 GLN A CD    1 
ATOM   1973 O  OE1   . GLN A 1 250 ? 179.825 153.887 157.476 1.00 265.73 ? 250 GLN A OE1   1 
ATOM   1974 N  NE2   . GLN A 1 250 ? 181.539 152.442 157.606 1.00 265.73 ? 250 GLN A NE2   1 
ATOM   1975 N  N     . LEU A 1 251 ? 176.281 150.023 155.708 1.00 272.27 ? 251 LEU A N     1 
ATOM   1976 C  CA    . LEU A 1 251 ? 175.884 148.689 156.150 1.00 272.27 ? 251 LEU A CA    1 
ATOM   1977 C  C     . LEU A 1 251 ? 175.522 147.788 154.975 1.00 272.27 ? 251 LEU A C     1 
ATOM   1978 O  O     . LEU A 1 251 ? 175.844 146.594 154.991 1.00 272.27 ? 251 LEU A O     1 
ATOM   1979 C  CB    . LEU A 1 251 ? 174.715 148.781 157.130 1.00 272.27 ? 251 LEU A CB    1 
ATOM   1980 C  CG    . LEU A 1 251 ? 175.069 148.814 158.621 1.00 272.27 ? 251 LEU A CG    1 
ATOM   1981 C  CD1   . LEU A 1 251 ? 175.740 147.513 159.034 1.00 272.27 ? 251 LEU A CD1   1 
ATOM   1982 C  CD2   . LEU A 1 251 ? 175.955 150.003 158.964 1.00 272.27 ? 251 LEU A CD2   1 
ATOM   1983 N  N     . SER A 1 252 ? 174.850 148.329 153.957 1.00 274.47 ? 252 SER A N     1 
ATOM   1984 C  CA    . SER A 1 252 ? 174.544 147.541 152.768 1.00 274.47 ? 252 SER A CA    1 
ATOM   1985 C  C     . SER A 1 252 ? 175.817 147.126 152.044 1.00 274.47 ? 252 SER A C     1 
ATOM   1986 O  O     . SER A 1 252 ? 175.933 145.985 151.578 1.00 274.47 ? 252 SER A O     1 
ATOM   1987 C  CB    . SER A 1 252 ? 173.630 148.334 151.835 1.00 274.47 ? 252 SER A CB    1 
ATOM   1988 O  OG    . SER A 1 252 ? 172.461 148.765 152.511 1.00 274.47 ? 252 SER A OG    1 
ATOM   1989 N  N     . ASN A 1 253 ? 176.786 148.039 151.939 1.00 296.19 ? 253 ASN A N     1 
ATOM   1990 C  CA    . ASN A 1 253 ? 178.065 147.690 151.330 1.00 296.19 ? 253 ASN A CA    1 
ATOM   1991 C  C     . ASN A 1 253 ? 178.777 146.611 152.134 1.00 296.19 ? 253 ASN A C     1 
ATOM   1992 O  O     . ASN A 1 253 ? 179.390 145.702 151.562 1.00 296.19 ? 253 ASN A O     1 
ATOM   1993 C  CB    . ASN A 1 253 ? 178.946 148.933 151.200 1.00 296.19 ? 253 ASN A CB    1 
ATOM   1994 C  CG    . ASN A 1 253 ? 178.300 150.018 150.364 1.00 296.19 ? 253 ASN A CG    1 
ATOM   1995 O  OD1   . ASN A 1 253 ? 177.574 149.736 149.412 1.00 296.19 ? 253 ASN A OD1   1 
ATOM   1996 N  ND2   . ASN A 1 253 ? 178.561 151.272 150.718 1.00 296.19 ? 253 ASN A ND2   1 
ATOM   1997 N  N     . ILE A 1 254 ? 178.710 146.699 153.464 1.00 300.78 ? 254 ILE A N     1 
ATOM   1998 C  CA    . ILE A 1 254 ? 179.303 145.670 154.314 1.00 300.78 ? 254 ILE A CA    1 
ATOM   1999 C  C     . ILE A 1 254 ? 178.636 144.323 154.064 1.00 300.78 ? 254 ILE A C     1 
ATOM   2000 O  O     . ILE A 1 254 ? 179.309 143.294 153.932 1.00 300.78 ? 254 ILE A O     1 
ATOM   2001 C  CB    . ILE A 1 254 ? 179.207 146.085 155.794 1.00 300.78 ? 254 ILE A CB    1 
ATOM   2002 C  CG1   . ILE A 1 254 ? 180.260 147.146 156.122 1.00 300.78 ? 254 ILE A CG1   1 
ATOM   2003 C  CG2   . ILE A 1 254 ? 179.362 144.876 156.707 1.00 300.78 ? 254 ILE A CG2   1 
ATOM   2004 C  CD1   . ILE A 1 254 ? 179.837 148.108 157.211 1.00 300.78 ? 254 ILE A CD1   1 
ATOM   2005 N  N     . GLU A 1 255 ? 177.302 144.311 153.987 1.00 299.50 ? 255 GLU A N     1 
ATOM   2006 C  CA    . GLU A 1 255 ? 176.582 143.061 153.761 1.00 299.50 ? 255 GLU A CA    1 
ATOM   2007 C  C     . GLU A 1 255 ? 176.936 142.451 152.411 1.00 299.50 ? 255 GLU A C     1 
ATOM   2008 O  O     . GLU A 1 255 ? 177.138 141.236 152.304 1.00 299.50 ? 255 GLU A O     1 
ATOM   2009 C  CB    . GLU A 1 255 ? 175.075 143.296 153.859 1.00 299.50 ? 255 GLU A CB    1 
ATOM   2010 C  CG    . GLU A 1 255 ? 174.249 142.024 153.741 1.00 299.50 ? 255 GLU A CG    1 
ATOM   2011 C  CD    . GLU A 1 255 ? 173.026 142.033 154.635 1.00 299.50 ? 255 GLU A CD    1 
ATOM   2012 O  OE1   . GLU A 1 255 ? 172.733 143.088 155.234 1.00 299.50 ? 255 GLU A OE1   1 
ATOM   2013 O  OE2   . GLU A 1 255 ? 172.357 140.984 154.740 1.00 299.50 ? 255 GLU A OE2   1 
ATOM   2014 N  N     . GLU A 1 256 ? 177.013 143.278 151.366 1.00 313.20 ? 256 GLU A N     1 
ATOM   2015 C  CA    . GLU A 1 256 ? 177.321 142.756 150.038 1.00 313.20 ? 256 GLU A CA    1 
ATOM   2016 C  C     . GLU A 1 256 ? 178.759 142.256 149.958 1.00 313.20 ? 256 GLU A C     1 
ATOM   2017 O  O     . GLU A 1 256 ? 179.020 141.172 149.423 1.00 313.20 ? 256 GLU A O     1 
ATOM   2018 C  CB    . GLU A 1 256 ? 177.063 143.828 148.976 1.00 313.20 ? 256 GLU A CB    1 
ATOM   2019 C  CG    . GLU A 1 256 ? 175.625 144.321 148.921 1.00 313.20 ? 256 GLU A CG    1 
ATOM   2020 C  CD    . GLU A 1 256 ? 174.617 143.224 149.203 1.00 313.20 ? 256 GLU A CD    1 
ATOM   2021 O  OE1   . GLU A 1 256 ? 174.526 142.276 148.396 1.00 313.20 ? 256 GLU A OE1   1 
ATOM   2022 O  OE2   . GLU A 1 256 ? 173.915 143.312 150.233 1.00 313.20 ? 256 GLU A OE2   1 
ATOM   2023 N  N     . THR A 1 257 ? 179.707 143.033 150.484 1.00 322.74 ? 257 THR A N     1 
ATOM   2024 C  CA    . THR A 1 257 ? 181.117 142.680 150.357 1.00 322.74 ? 257 THR A CA    1 
ATOM   2025 C  C     . THR A 1 257 ? 181.510 141.534 151.284 1.00 322.74 ? 257 THR A C     1 
ATOM   2026 O  O     . THR A 1 257 ? 182.240 140.626 150.872 1.00 322.74 ? 257 THR A O     1 
ATOM   2027 C  CB    . THR A 1 257 ? 181.991 143.904 150.634 1.00 322.74 ? 257 THR A CB    1 
ATOM   2028 O  OG1   . THR A 1 257 ? 181.608 144.496 151.881 1.00 322.74 ? 257 THR A OG1   1 
ATOM   2029 C  CG2   . THR A 1 257 ? 181.838 144.930 149.521 1.00 322.74 ? 257 THR A CG2   1 
ATOM   2030 N  N     . SER A 1 258 ? 181.041 141.555 152.528 1.00 314.31 ? 258 SER A N     1 
ATOM   2031 C  CA    . SER A 1 258 ? 181.473 140.602 153.541 1.00 314.31 ? 258 SER A CA    1 
ATOM   2032 C  C     . SER A 1 258 ? 180.473 139.460 153.654 1.00 314.31 ? 258 SER A C     1 
ATOM   2033 O  O     . SER A 1 258 ? 179.264 139.693 153.758 1.00 314.31 ? 258 SER A O     1 
ATOM   2034 C  CB    . SER A 1 258 ? 181.639 141.288 154.899 1.00 314.31 ? 258 SER A CB    1 
ATOM   2035 O  OG    . SER A 1 258 ? 180.429 141.902 155.311 1.00 314.31 ? 258 SER A OG    1 
ATOM   2036 N  N     . ASN A 1 259 ? 180.983 138.231 153.631 1.00 294.06 ? 259 ASN A N     1 
ATOM   2037 C  CA    . ASN A 1 259 ? 180.139 137.066 153.848 1.00 294.06 ? 259 ASN A CA    1 
ATOM   2038 C  C     . ASN A 1 259 ? 179.663 137.020 155.294 1.00 294.06 ? 259 ASN A C     1 
ATOM   2039 O  O     . ASN A 1 259 ? 180.365 137.438 156.219 1.00 294.06 ? 259 ASN A O     1 
ATOM   2040 C  CB    . ASN A 1 259 ? 180.896 135.784 153.502 1.00 294.06 ? 259 ASN A CB    1 
ATOM   2041 C  CG    . ASN A 1 259 ? 181.902 135.395 154.567 1.00 294.06 ? 259 ASN A CG    1 
ATOM   2042 O  OD1   . ASN A 1 259 ? 182.961 136.010 154.690 1.00 294.06 ? 259 ASN A OD1   1 
ATOM   2043 N  ND2   . ASN A 1 259 ? 181.573 134.372 155.348 1.00 294.06 ? 259 ASN A ND2   1 
ATOM   2044 N  N     . LEU A 1 260 ? 178.449 136.511 155.484 1.00 274.33 ? 260 LEU A N     1 
ATOM   2045 C  CA    . LEU A 1 260 ? 177.830 136.436 156.800 1.00 274.33 ? 260 LEU A CA    1 
ATOM   2046 C  C     . LEU A 1 260 ? 177.387 135.007 157.066 1.00 274.33 ? 260 LEU A C     1 
ATOM   2047 O  O     . LEU A 1 260 ? 176.741 134.386 156.216 1.00 274.33 ? 260 LEU A O     1 
ATOM   2048 C  CB    . LEU A 1 260 ? 176.636 137.390 156.901 1.00 274.33 ? 260 LEU A CB    1 
ATOM   2049 C  CG    . LEU A 1 260 ? 176.785 138.721 156.163 1.00 274.33 ? 260 LEU A CG    1 
ATOM   2050 C  CD1   . LEU A 1 260 ? 175.438 139.397 155.991 1.00 274.33 ? 260 LEU A CD1   1 
ATOM   2051 C  CD2   . LEU A 1 260 ? 177.759 139.633 156.894 1.00 274.33 ? 260 LEU A CD2   1 
ATOM   2052 N  N     . ASN A 1 261 ? 177.739 134.488 158.246 1.00 278.79 ? 261 ASN A N     1 
ATOM   2053 C  CA    . ASN A 1 261 ? 177.243 133.175 158.646 1.00 278.79 ? 261 ASN A CA    1 
ATOM   2054 C  C     . ASN A 1 261 ? 175.727 133.178 158.773 1.00 278.79 ? 261 ASN A C     1 
ATOM   2055 O  O     . ASN A 1 261 ? 175.066 132.210 158.380 1.00 278.79 ? 261 ASN A O     1 
ATOM   2056 C  CB    . ASN A 1 261 ? 177.886 132.746 159.964 1.00 278.79 ? 261 ASN A CB    1 
ATOM   2057 C  CG    . ASN A 1 261 ? 177.495 131.340 160.372 1.00 278.79 ? 261 ASN A CG    1 
ATOM   2058 O  OD1   . ASN A 1 261 ? 177.273 130.475 159.526 1.00 278.79 ? 261 ASN A OD1   1 
ATOM   2059 N  ND2   . ASN A 1 261 ? 177.406 131.106 161.677 1.00 278.79 ? 261 ASN A ND2   1 
ATOM   2060 N  N     . ASP A 1 262 ? 175.161 134.254 159.317 1.00 312.04 ? 262 ASP A N     1 
ATOM   2061 C  CA    . ASP A 1 262 ? 173.716 134.451 159.386 1.00 312.04 ? 262 ASP A CA    1 
ATOM   2062 C  C     . ASP A 1 262 ? 173.416 135.795 158.732 1.00 312.04 ? 262 ASP A C     1 
ATOM   2063 O  O     . ASP A 1 262 ? 173.463 136.837 159.394 1.00 312.04 ? 262 ASP A O     1 
ATOM   2064 C  CB    . ASP A 1 262 ? 173.216 134.404 160.827 1.00 312.04 ? 262 ASP A CB    1 
ATOM   2065 C  CG    . ASP A 1 262 ? 171.714 134.584 160.930 1.00 312.04 ? 262 ASP A CG    1 
ATOM   2066 O  OD1   . ASP A 1 262 ? 170.995 134.118 160.022 1.00 312.04 ? 262 ASP A OD1   1 
ATOM   2067 O  OD2   . ASP A 1 262 ? 171.251 135.192 161.918 1.00 312.04 ? 262 ASP A OD2   1 
ATOM   2068 N  N     . THR A 1 263 ? 173.122 135.773 157.429 1.00 310.40 ? 263 THR A N     1 
ATOM   2069 C  CA    . THR A 1 263 ? 172.786 137.007 156.725 1.00 310.40 ? 263 THR A CA    1 
ATOM   2070 C  C     . THR A 1 263 ? 171.518 137.636 157.284 1.00 310.40 ? 263 THR A C     1 
ATOM   2071 O  O     . THR A 1 263 ? 171.340 138.859 157.205 1.00 310.40 ? 263 THR A O     1 
ATOM   2072 C  CB    . THR A 1 263 ? 172.633 136.732 155.229 1.00 310.40 ? 263 THR A CB    1 
ATOM   2073 O  OG1   . THR A 1 263 ? 171.498 135.884 155.010 1.00 310.40 ? 263 THR A OG1   1 
ATOM   2074 C  CG2   . THR A 1 263 ? 173.879 136.051 154.682 1.00 310.40 ? 263 THR A CG2   1 
ATOM   2075 N  N     . ASN A 1 264 ? 170.634 136.818 157.861 1.00 315.53 ? 264 ASN A N     1 
ATOM   2076 C  CA    . ASN A 1 264 ? 169.444 137.349 158.516 1.00 315.53 ? 264 ASN A CA    1 
ATOM   2077 C  C     . ASN A 1 264 ? 169.803 138.228 159.706 1.00 315.53 ? 264 ASN A C     1 
ATOM   2078 O  O     . ASN A 1 264 ? 169.050 139.144 160.039 1.00 315.53 ? 264 ASN A O     1 
ATOM   2079 C  CB    . ASN A 1 264 ? 168.530 136.206 158.959 1.00 315.53 ? 264 ASN A CB    1 
ATOM   2080 C  CG    . ASN A 1 264 ? 167.071 136.618 159.026 1.00 315.53 ? 264 ASN A CG    1 
ATOM   2081 O  OD1   . ASN A 1 264 ? 166.745 137.805 158.975 1.00 315.53 ? 264 ASN A OD1   1 
ATOM   2082 N  ND2   . ASN A 1 264 ? 166.184 135.638 159.152 1.00 315.53 ? 264 ASN A ND2   1 
ATOM   2083 N  N     . SER A 1 265 ? 170.950 137.985 160.345 1.00 314.83 ? 265 SER A N     1 
ATOM   2084 C  CA    . SER A 1 265 ? 171.365 138.826 161.466 1.00 314.83 ? 265 SER A CA    1 
ATOM   2085 C  C     . SER A 1 265 ? 171.667 140.249 161.007 1.00 314.83 ? 265 SER A C     1 
ATOM   2086 O  O     . SER A 1 265 ? 171.190 141.224 161.602 1.00 314.83 ? 265 SER A O     1 
ATOM   2087 C  CB    . SER A 1 265 ? 172.584 138.215 162.155 1.00 314.83 ? 265 SER A CB    1 
ATOM   2088 O  OG    . SER A 1 265 ? 172.228 137.071 162.911 1.00 314.83 ? 265 SER A OG    1 
ATOM   2089 N  N     . LEU A 1 266 ? 172.463 140.390 159.945 1.00 299.67 ? 266 LEU A N     1 
ATOM   2090 C  CA    . LEU A 1 266 ? 172.762 141.723 159.435 1.00 299.67 ? 266 LEU A CA    1 
ATOM   2091 C  C     . LEU A 1 266 ? 171.532 142.357 158.798 1.00 299.67 ? 266 LEU A C     1 
ATOM   2092 O  O     . LEU A 1 266 ? 171.364 143.582 158.855 1.00 299.67 ? 266 LEU A O     1 
ATOM   2093 C  CB    . LEU A 1 266 ? 173.914 141.658 158.435 1.00 299.67 ? 266 LEU A CB    1 
ATOM   2094 C  CG    . LEU A 1 266 ? 174.505 143.000 158.010 1.00 299.67 ? 266 LEU A CG    1 
ATOM   2095 C  CD1   . LEU A 1 266 ? 174.662 143.915 159.215 1.00 299.67 ? 266 LEU A CD1   1 
ATOM   2096 C  CD2   . LEU A 1 266 ? 175.841 142.786 157.332 1.00 299.67 ? 266 LEU A CD2   1 
ATOM   2097 N  N     . LYS A 1 267 ? 170.657 141.540 158.205 1.00 282.00 ? 267 LYS A N     1 
ATOM   2098 C  CA    . LYS A 1 267 ? 169.372 142.054 157.746 1.00 282.00 ? 267 LYS A CA    1 
ATOM   2099 C  C     . LYS A 1 267 ? 168.568 142.617 158.910 1.00 282.00 ? 267 LYS A C     1 
ATOM   2100 O  O     . LYS A 1 267 ? 167.910 143.656 158.776 1.00 282.00 ? 267 LYS A O     1 
ATOM   2101 C  CB    . LYS A 1 267 ? 168.588 140.952 157.037 1.00 282.00 ? 267 LYS A CB    1 
ATOM   2102 C  CG    . LYS A 1 267 ? 168.954 140.767 155.577 1.00 282.00 ? 267 LYS A CG    1 
ATOM   2103 C  CD    . LYS A 1 267 ? 168.052 139.744 154.913 1.00 282.00 ? 267 LYS A CD    1 
ATOM   2104 C  CE    . LYS A 1 267 ? 168.829 138.907 153.915 1.00 282.00 ? 267 LYS A CE    1 
ATOM   2105 N  NZ    . LYS A 1 267 ? 168.937 137.491 154.359 1.00 282.00 ? 267 LYS A NZ    1 
ATOM   2106 N  N     . GLN A 1 268 ? 168.604 141.942 160.062 1.00 267.85 ? 268 GLN A N     1 
ATOM   2107 C  CA    . GLN A 1 268 ? 167.919 142.450 161.244 1.00 267.85 ? 268 GLN A CA    1 
ATOM   2108 C  C     . GLN A 1 268 ? 168.545 143.752 161.718 1.00 267.85 ? 268 GLN A C     1 
ATOM   2109 O  O     . GLN A 1 268 ? 167.838 144.661 162.168 1.00 267.85 ? 268 GLN A O     1 
ATOM   2110 C  CB    . GLN A 1 268 ? 167.946 141.414 162.364 1.00 267.85 ? 268 GLN A CB    1 
ATOM   2111 C  CG    . GLN A 1 268 ? 166.882 140.351 162.253 1.00 267.85 ? 268 GLN A CG    1 
ATOM   2112 C  CD    . GLN A 1 268 ? 167.341 139.041 162.839 1.00 267.85 ? 268 GLN A CD    1 
ATOM   2113 O  OE1   . GLN A 1 268 ? 168.381 138.977 163.497 1.00 267.85 ? 268 GLN A OE1   1 
ATOM   2114 N  NE2   . GLN A 1 268 ? 166.572 137.986 162.612 1.00 267.85 ? 268 GLN A NE2   1 
ATOM   2115 N  N     . ILE A 1 269 ? 169.872 143.848 161.640 1.00 262.97 ? 269 ILE A N     1 
ATOM   2116 C  CA    . ILE A 1 269 ? 170.546 145.092 162.004 1.00 262.97 ? 269 ILE A CA    1 
ATOM   2117 C  C     . ILE A 1 269 ? 170.042 146.234 161.128 1.00 262.97 ? 269 ILE A C     1 
ATOM   2118 O  O     . ILE A 1 269 ? 169.601 147.281 161.622 1.00 262.97 ? 269 ILE A O     1 
ATOM   2119 C  CB    . ILE A 1 269 ? 172.072 144.927 161.882 1.00 262.97 ? 269 ILE A CB    1 
ATOM   2120 C  CG1   . ILE A 1 269 ? 172.568 143.851 162.853 1.00 262.97 ? 269 ILE A CG1   1 
ATOM   2121 C  CG2   . ILE A 1 269 ? 172.780 146.259 162.125 1.00 262.97 ? 269 ILE A CG2   1 
ATOM   2122 C  CD1   . ILE A 1 269 ? 172.197 144.109 164.293 1.00 262.97 ? 269 ILE A CD1   1 
ATOM   2123 N  N     . LYS A 1 270 ? 170.049 146.021 159.812 1.00 239.68 ? 270 LYS A N     1 
ATOM   2124 C  CA    . LYS A 1 270 ? 169.602 147.052 158.881 1.00 239.68 ? 270 LYS A CA    1 
ATOM   2125 C  C     . LYS A 1 270 ? 168.133 147.403 159.101 1.00 239.68 ? 270 LYS A C     1 
ATOM   2126 O  O     . LYS A 1 270 ? 167.746 148.578 159.019 1.00 239.68 ? 270 LYS A O     1 
ATOM   2127 C  CB    . LYS A 1 270 ? 169.831 146.590 157.443 1.00 239.68 ? 270 LYS A CB    1 
ATOM   2128 C  CG    . LYS A 1 270 ? 171.277 146.272 157.112 1.00 239.68 ? 270 LYS A CG    1 
ATOM   2129 C  CD    . LYS A 1 270 ? 171.462 146.012 155.627 1.00 239.68 ? 270 LYS A CD    1 
ATOM   2130 C  CE    . LYS A 1 270 ? 170.750 147.068 154.806 1.00 239.68 ? 270 LYS A CE    1 
ATOM   2131 N  NZ    . LYS A 1 270 ? 171.342 148.414 155.037 1.00 239.68 ? 270 LYS A NZ    1 
ATOM   2132 N  N     . LYS A 1 271 ? 167.294 146.401 159.375 1.00 215.11 ? 271 LYS A N     1 
ATOM   2133 C  CA    . LYS A 1 271 ? 165.868 146.678 159.484 1.00 215.11 ? 271 LYS A CA    1 
ATOM   2134 C  C     . LYS A 1 271 ? 165.528 147.394 160.791 1.00 215.11 ? 271 LYS A C     1 
ATOM   2135 O  O     . LYS A 1 271 ? 164.692 148.307 160.791 1.00 215.11 ? 271 LYS A O     1 
ATOM   2136 C  CB    . LYS A 1 271 ? 165.061 145.389 159.322 1.00 215.11 ? 271 LYS A CB    1 
ATOM   2137 C  CG    . LYS A 1 271 ? 165.201 144.379 160.397 1.00 215.11 ? 271 LYS A CG    1 
ATOM   2138 C  CD    . LYS A 1 271 ? 164.151 144.521 161.473 1.00 215.11 ? 271 LYS A CD    1 
ATOM   2139 C  CE    . LYS A 1 271 ? 164.322 143.405 162.498 1.00 215.11 ? 271 LYS A CE    1 
ATOM   2140 N  NZ    . LYS A 1 271 ? 163.260 143.425 163.563 1.00 215.11 ? 271 LYS A NZ    1 
ATOM   2141 N  N     . VAL A 1 272 ? 166.165 147.022 161.907 1.00 219.09 ? 272 VAL A N     1 
ATOM   2142 C  CA    . VAL A 1 272 ? 165.964 147.806 163.123 1.00 219.09 ? 272 VAL A CA    1 
ATOM   2143 C  C     . VAL A 1 272 ? 166.514 149.210 162.926 1.00 219.09 ? 272 VAL A C     1 
ATOM   2144 O  O     . VAL A 1 272 ? 165.975 150.184 163.473 1.00 219.09 ? 272 VAL A O     1 
ATOM   2145 C  CB    . VAL A 1 272 ? 166.583 147.112 164.355 1.00 219.09 ? 272 VAL A CB    1 
ATOM   2146 C  CG1   . VAL A 1 272 ? 165.979 145.728 164.552 1.00 219.09 ? 272 VAL A CG1   1 
ATOM   2147 C  CG2   . VAL A 1 272 ? 168.101 147.028 164.236 1.00 219.09 ? 272 VAL A CG2   1 
ATOM   2148 N  N     . LEU A 1 273 ? 167.559 149.346 162.107 1.00 226.05 ? 273 LEU A N     1 
ATOM   2149 C  CA    . LEU A 1 273 ? 168.063 150.671 161.778 1.00 226.05 ? 273 LEU A CA    1 
ATOM   2150 C  C     . LEU A 1 273 ? 167.004 151.495 161.054 1.00 226.05 ? 273 LEU A C     1 
ATOM   2151 O  O     . LEU A 1 273 ? 166.814 152.683 161.358 1.00 226.05 ? 273 LEU A O     1 
ATOM   2152 C  CB    . LEU A 1 273 ? 169.346 150.560 160.947 1.00 226.05 ? 273 LEU A CB    1 
ATOM   2153 C  CG    . LEU A 1 273 ? 169.858 151.830 160.248 1.00 226.05 ? 273 LEU A CG    1 
ATOM   2154 C  CD1   . LEU A 1 273 ? 171.365 152.007 160.410 1.00 226.05 ? 273 LEU A CD1   1 
ATOM   2155 C  CD2   . LEU A 1 273 ? 169.476 151.858 158.766 1.00 226.05 ? 273 LEU A CD2   1 
ATOM   2156 N  N     . ARG A 1 274 ? 166.309 150.900 160.076 1.00 212.35 ? 274 ARG A N     1 
ATOM   2157 C  CA    . ARG A 1 274 ? 165.432 151.792 159.325 1.00 212.35 ? 274 ARG A CA    1 
ATOM   2158 C  C     . ARG A 1 274 ? 164.173 152.036 160.135 1.00 212.35 ? 274 ARG A C     1 
ATOM   2159 O  O     . ARG A 1 274 ? 163.510 153.063 159.969 1.00 212.35 ? 274 ARG A O     1 
ATOM   2160 C  CB    . ARG A 1 274 ? 165.058 151.283 157.919 1.00 212.35 ? 274 ARG A CB    1 
ATOM   2161 C  CG    . ARG A 1 274 ? 164.693 149.834 157.514 1.00 212.35 ? 274 ARG A CG    1 
ATOM   2162 C  CD    . ARG A 1 274 ? 163.390 149.311 158.190 1.00 212.35 ? 274 ARG A CD    1 
ATOM   2163 N  NE    . ARG A 1 274 ? 163.197 147.861 158.119 1.00 212.35 ? 274 ARG A NE    1 
ATOM   2164 C  CZ    . ARG A 1 274 ? 162.263 147.186 158.781 1.00 212.35 ? 274 ARG A CZ    1 
ATOM   2165 N  NH1   . ARG A 1 274 ? 161.379 147.800 159.544 1.00 212.35 ? 274 ARG A NH1   1 
ATOM   2166 N  NH2   . ARG A 1 274 ? 162.154 145.872 158.602 1.00 212.35 ? 274 ARG A NH2   1 
ATOM   2167 N  N     . ASP A 1 275 ? 163.857 151.114 161.046 1.00 203.27 ? 275 ASP A N     1 
ATOM   2168 C  CA    . ASP A 1 275 ? 162.828 151.376 162.045 1.00 203.27 ? 275 ASP A CA    1 
ATOM   2169 C  C     . ASP A 1 275 ? 163.179 152.604 162.872 1.00 203.27 ? 275 ASP A C     1 
ATOM   2170 O  O     . ASP A 1 275 ? 162.338 153.481 163.086 1.00 203.27 ? 275 ASP A O     1 
ATOM   2171 C  CB    . ASP A 1 275 ? 162.663 150.152 162.945 1.00 203.27 ? 275 ASP A CB    1 
ATOM   2172 C  CG    . ASP A 1 275 ? 162.013 148.999 162.226 1.00 203.27 ? 275 ASP A CG    1 
ATOM   2173 O  OD1   . ASP A 1 275 ? 161.602 149.196 161.065 1.00 203.27 ? 275 ASP A OD1   1 
ATOM   2174 O  OD2   . ASP A 1 275 ? 161.952 147.894 162.803 1.00 203.27 ? 275 ASP A OD2   1 
ATOM   2175 N  N     . ILE A 1 276 ? 164.427 152.688 163.334 1.00 184.96 ? 276 ILE A N     1 
ATOM   2176 C  CA    . ILE A 1 276 ? 164.847 153.843 164.125 1.00 184.96 ? 276 ILE A CA    1 
ATOM   2177 C  C     . ILE A 1 276 ? 164.765 155.118 163.290 1.00 184.96 ? 276 ILE A C     1 
ATOM   2178 O  O     . ILE A 1 276 ? 164.320 156.171 163.772 1.00 184.96 ? 276 ILE A O     1 
ATOM   2179 C  CB    . ILE A 1 276 ? 166.260 153.601 164.683 1.00 184.96 ? 276 ILE A CB    1 
ATOM   2180 C  CG1   . ILE A 1 276 ? 166.210 152.544 165.790 1.00 184.96 ? 276 ILE A CG1   1 
ATOM   2181 C  CG2   . ILE A 1 276 ? 166.863 154.898 165.192 1.00 184.96 ? 276 ILE A CG2   1 
ATOM   2182 C  CD1   . ILE A 1 276 ? 167.459 151.693 165.881 1.00 184.96 ? 276 ILE A CD1   1 
ATOM   2183 N  N     . LYS A 1 277 ? 165.169 155.036 162.019 1.00 187.01 ? 277 LYS A N     1 
ATOM   2184 C  CA    . LYS A 1 277 ? 165.021 156.180 161.120 1.00 187.01 ? 277 LYS A CA    1 
ATOM   2185 C  C     . LYS A 1 277 ? 163.558 156.600 160.999 1.00 187.01 ? 277 LYS A C     1 
ATOM   2186 O  O     . LYS A 1 277 ? 163.240 157.795 161.008 1.00 187.01 ? 277 LYS A O     1 
ATOM   2187 C  CB    . LYS A 1 277 ? 165.607 155.840 159.748 1.00 187.01 ? 277 LYS A CB    1 
ATOM   2188 C  CG    . LYS A 1 277 ? 164.773 156.293 158.554 1.00 187.01 ? 277 LYS A CG    1 
ATOM   2189 C  CD    . LYS A 1 277 ? 165.116 157.708 158.129 1.00 187.01 ? 277 LYS A CD    1 
ATOM   2190 C  CE    . LYS A 1 277 ? 164.675 157.967 156.698 1.00 187.01 ? 277 LYS A CE    1 
ATOM   2191 N  NZ    . LYS A 1 277 ? 163.192 157.957 156.553 1.00 187.01 ? 277 LYS A NZ    1 
ATOM   2192 N  N     . ASN A 1 278 ? 162.654 155.622 160.901 1.00 177.19 ? 278 ASN A N     1 
ATOM   2193 C  CA    . ASN A 1 278 ? 161.229 155.919 160.809 1.00 177.19 ? 278 ASN A CA    1 
ATOM   2194 C  C     . ASN A 1 278 ? 160.716 156.596 162.074 1.00 177.19 ? 278 ASN A C     1 
ATOM   2195 O  O     . ASN A 1 278 ? 159.914 157.532 161.997 1.00 177.19 ? 278 ASN A O     1 
ATOM   2196 C  CB    . ASN A 1 278 ? 160.448 154.636 160.532 1.00 177.19 ? 278 ASN A CB    1 
ATOM   2197 C  CG    . ASN A 1 278 ? 160.851 153.980 159.226 1.00 177.19 ? 278 ASN A CG    1 
ATOM   2198 O  OD1   . ASN A 1 278 ? 160.988 152.760 159.147 1.00 177.19 ? 278 ASN A OD1   1 
ATOM   2199 N  ND2   . ASN A 1 278 ? 161.024 154.789 158.188 1.00 177.19 ? 278 ASN A ND2   1 
ATOM   2200 N  N     . ILE A 1 279 ? 161.145 156.122 163.248 1.00 169.29 ? 279 ILE A N     1 
ATOM   2201 C  CA    . ILE A 1 279 ? 160.738 156.779 164.493 1.00 169.29 ? 279 ILE A CA    1 
ATOM   2202 C  C     . ILE A 1 279 ? 161.252 158.211 164.532 1.00 169.29 ? 279 ILE A C     1 
ATOM   2203 O  O     . ILE A 1 279 ? 160.563 159.115 165.020 1.00 169.29 ? 279 ILE A O     1 
ATOM   2204 C  CB    . ILE A 1 279 ? 161.184 155.993 165.744 1.00 169.29 ? 279 ILE A CB    1 
ATOM   2205 C  CG1   . ILE A 1 279 ? 161.180 154.483 165.530 1.00 169.29 ? 279 ILE A CG1   1 
ATOM   2206 C  CG2   . ILE A 1 279 ? 160.297 156.333 166.931 1.00 169.29 ? 279 ILE A CG2   1 
ATOM   2207 C  CD1   . ILE A 1 279 ? 159.843 153.919 165.086 1.00 169.29 ? 279 ILE A CD1   1 
ATOM   2208 N  N     . LEU A 1 280 ? 162.469 158.443 164.036 1.00 175.88 ? 280 LEU A N     1 
ATOM   2209 C  CA    . LEU A 1 280 ? 162.955 159.819 163.963 1.00 175.88 ? 280 LEU A CA    1 
ATOM   2210 C  C     . LEU A 1 280 ? 162.054 160.656 163.063 1.00 175.88 ? 280 LEU A C     1 
ATOM   2211 O  O     . LEU A 1 280 ? 161.690 161.786 163.411 1.00 175.88 ? 280 LEU A O     1 
ATOM   2212 C  CB    . LEU A 1 280 ? 164.399 159.859 163.457 1.00 175.88 ? 280 LEU A CB    1 
ATOM   2213 C  CG    . LEU A 1 280 ? 164.851 161.114 162.691 1.00 175.88 ? 280 LEU A CG    1 
ATOM   2214 C  CD1   . LEU A 1 280 ? 164.805 162.374 163.561 1.00 175.88 ? 280 LEU A CD1   1 
ATOM   2215 C  CD2   . LEU A 1 280 ? 166.235 160.940 162.097 1.00 175.88 ? 280 LEU A CD2   1 
ATOM   2216 N  N     . ASP A 1 281 ? 161.670 160.109 161.907 1.00 176.39 ? 281 ASP A N     1 
ATOM   2217 C  CA    . ASP A 1 281 ? 160.826 160.856 160.978 1.00 176.39 ? 281 ASP A CA    1 
ATOM   2218 C  C     . ASP A 1 281 ? 159.465 161.171 161.589 1.00 176.39 ? 281 ASP A C     1 
ATOM   2219 O  O     . ASP A 1 281 ? 159.003 162.317 161.552 1.00 176.39 ? 281 ASP A O     1 
ATOM   2220 C  CB    . ASP A 1 281 ? 160.657 160.075 159.675 1.00 176.39 ? 281 ASP A CB    1 
ATOM   2221 C  CG    . ASP A 1 281 ? 161.975 159.622 159.094 1.00 176.39 ? 281 ASP A CG    1 
ATOM   2222 O  OD1   . ASP A 1 281 ? 162.992 160.313 159.312 1.00 176.39 ? 281 ASP A OD1   1 
ATOM   2223 O  OD2   . ASP A 1 281 ? 161.995 158.571 158.422 1.00 176.39 ? 281 ASP A OD2   1 
ATOM   2224 N  N     . GLU A 1 282 ? 158.809 160.162 162.161 1.00 163.45 ? 282 GLU A N     1 
ATOM   2225 C  CA    . GLU A 1 282 ? 157.444 160.334 162.641 1.00 163.45 ? 282 GLU A CA    1 
ATOM   2226 C  C     . GLU A 1 282 ? 157.392 161.096 163.959 1.00 163.45 ? 282 GLU A C     1 
ATOM   2227 O  O     . GLU A 1 282 ? 156.470 161.888 164.180 1.00 163.45 ? 282 GLU A O     1 
ATOM   2228 C  CB    . GLU A 1 282 ? 156.765 158.973 162.794 1.00 163.45 ? 282 GLU A CB    1 
ATOM   2229 C  CG    . GLU A 1 282 ? 156.696 158.169 161.510 1.00 163.45 ? 282 GLU A CG    1 
ATOM   2230 C  CD    . GLU A 1 282 ? 156.023 158.931 160.385 1.00 163.45 ? 282 GLU A CD    1 
ATOM   2231 O  OE1   . GLU A 1 282 ? 154.978 159.567 160.638 1.00 163.45 ? 282 GLU A OE1   1 
ATOM   2232 O  OE2   . GLU A 1 282 ? 156.541 158.893 159.250 1.00 163.45 ? 282 GLU A OE2   1 
ATOM   2233 N  N     . LEU A 1 283 ? 158.361 160.875 164.842 1.00 164.01 ? 283 LEU A N     1 
ATOM   2234 C  CA    . LEU A 1 283 ? 158.307 161.429 166.189 1.00 164.01 ? 283 LEU A CA    1 
ATOM   2235 C  C     . LEU A 1 283 ? 159.346 162.505 166.454 1.00 164.01 ? 283 LEU A C     1 
ATOM   2236 O  O     . LEU A 1 283 ? 158.979 163.629 166.807 1.00 164.01 ? 283 LEU A O     1 
ATOM   2237 C  CB    . LEU A 1 283 ? 158.463 160.307 167.223 1.00 164.01 ? 283 LEU A CB    1 
ATOM   2238 C  CG    . LEU A 1 283 ? 157.187 159.543 167.585 1.00 164.01 ? 283 LEU A CG    1 
ATOM   2239 C  CD1   . LEU A 1 283 ? 156.758 158.610 166.461 1.00 164.01 ? 283 LEU A CD1   1 
ATOM   2240 C  CD2   . LEU A 1 283 ? 157.377 158.766 168.873 1.00 164.01 ? 283 LEU A CD2   1 
ATOM   2241 N  N     . GLY A 1 284 ? 160.632 162.208 166.289 1.00 192.28 ? 284 GLY A N     1 
ATOM   2242 C  CA    . GLY A 1 284 ? 161.662 163.193 166.517 1.00 192.28 ? 284 GLY A CA    1 
ATOM   2243 C  C     . GLY A 1 284 ? 162.953 162.617 167.061 1.00 192.28 ? 284 GLY A C     1 
ATOM   2244 O  O     . GLY A 1 284 ? 163.063 161.420 167.346 1.00 192.28 ? 284 GLY A O     1 
ATOM   2245 N  N     . PRO A 1 285 ? 163.967 163.475 167.211 1.00 189.53 ? 285 PRO A N     1 
ATOM   2246 C  CA    . PRO A 1 285 ? 165.282 162.981 167.653 1.00 189.53 ? 285 PRO A CA    1 
ATOM   2247 C  C     . PRO A 1 285 ? 165.295 162.419 169.063 1.00 189.53 ? 285 PRO A C     1 
ATOM   2248 O  O     . PRO A 1 285 ? 166.005 161.439 169.318 1.00 189.53 ? 285 PRO A O     1 
ATOM   2249 C  CB    . PRO A 1 285 ? 166.173 164.223 167.526 1.00 189.53 ? 285 PRO A CB    1 
ATOM   2250 C  CG    . PRO A 1 285 ? 165.239 165.371 167.683 1.00 189.53 ? 285 PRO A CG    1 
ATOM   2251 C  CD    . PRO A 1 285 ? 163.945 164.939 167.054 1.00 189.53 ? 285 PRO A CD    1 
ATOM   2252 N  N     . TRP A 1 286 ? 164.546 163.011 169.998 1.00 190.33 ? 286 TRP A N     1 
ATOM   2253 C  CA    . TRP A 1 286 ? 164.586 162.515 171.370 1.00 190.33 ? 286 TRP A CA    1 
ATOM   2254 C  C     . TRP A 1 286 ? 163.992 161.118 171.471 1.00 190.33 ? 286 TRP A C     1 
ATOM   2255 O  O     . TRP A 1 286 ? 164.534 160.255 172.172 1.00 190.33 ? 286 TRP A O     1 
ATOM   2256 C  CB    . TRP A 1 286 ? 163.851 163.464 172.316 1.00 190.33 ? 286 TRP A CB    1 
ATOM   2257 C  CG    . TRP A 1 286 ? 163.907 162.990 173.738 1.00 190.33 ? 286 TRP A CG    1 
ATOM   2258 C  CD1   . TRP A 1 286 ? 164.813 163.360 174.686 1.00 190.33 ? 286 TRP A CD1   1 
ATOM   2259 C  CD2   . TRP A 1 286 ? 163.039 162.036 174.363 1.00 190.33 ? 286 TRP A CD2   1 
ATOM   2260 N  NE1   . TRP A 1 286 ? 164.558 162.705 175.866 1.00 190.33 ? 286 TRP A NE1   1 
ATOM   2261 C  CE2   . TRP A 1 286 ? 163.474 161.885 175.693 1.00 190.33 ? 286 TRP A CE2   1 
ATOM   2262 C  CE3   . TRP A 1 286 ? 161.932 161.300 173.928 1.00 190.33 ? 286 TRP A CE3   1 
ATOM   2263 C  CZ2   . TRP A 1 286 ? 162.844 161.028 176.591 1.00 190.33 ? 286 TRP A CZ2   1 
ATOM   2264 C  CZ3   . TRP A 1 286 ? 161.309 160.449 174.821 1.00 190.33 ? 286 TRP A CZ3   1 
ATOM   2265 C  CH2   . TRP A 1 286 ? 161.764 160.323 176.138 1.00 190.33 ? 286 TRP A CH2   1 
ATOM   2266 N  N     . CYS A 1 287 ? 162.865 160.881 170.800 1.00 205.93 ? 287 CYS A N     1 
ATOM   2267 C  CA    . CYS A 1 287 ? 162.265 159.553 170.829 1.00 205.93 ? 287 CYS A CA    1 
ATOM   2268 C  C     . CYS A 1 287 ? 163.153 158.543 170.116 1.00 205.93 ? 287 CYS A C     1 
ATOM   2269 O  O     . CYS A 1 287 ? 163.249 157.381 170.533 1.00 205.93 ? 287 CYS A O     1 
ATOM   2270 C  CB    . CYS A 1 287 ? 160.872 159.599 170.204 1.00 205.93 ? 287 CYS A CB    1 
ATOM   2271 S  SG    . CYS A 1 287 ? 159.566 159.990 171.388 1.00 205.93 ? 287 CYS A SG    1 
ATOM   2272 N  N     . ALA A 1 288 ? 163.825 158.975 169.047 1.00 209.12 ? 288 ALA A N     1 
ATOM   2273 C  CA    . ALA A 1 288 ? 164.798 158.114 168.389 1.00 209.12 ? 288 ALA A CA    1 
ATOM   2274 C  C     . ALA A 1 288 ? 165.922 157.739 169.343 1.00 209.12 ? 288 ALA A C     1 
ATOM   2275 O  O     . ALA A 1 288 ? 166.341 156.581 169.389 1.00 209.12 ? 288 ALA A O     1 
ATOM   2276 C  CB    . ALA A 1 288 ? 165.355 158.801 167.142 1.00 209.12 ? 288 ALA A CB    1 
ATOM   2277 N  N     . HIS A 1 289 ? 166.405 158.699 170.135 1.00 218.10 ? 289 HIS A N     1 
ATOM   2278 C  CA    . HIS A 1 289 ? 167.466 158.405 171.093 1.00 218.10 ? 289 HIS A CA    1 
ATOM   2279 C  C     . HIS A 1 289 ? 166.977 157.501 172.220 1.00 218.10 ? 289 HIS A C     1 
ATOM   2280 O  O     . HIS A 1 289 ? 167.745 156.681 172.732 1.00 218.10 ? 289 HIS A O     1 
ATOM   2281 C  CB    . HIS A 1 289 ? 168.034 159.707 171.658 1.00 218.10 ? 289 HIS A CB    1 
ATOM   2282 C  CG    . HIS A 1 289 ? 168.845 159.525 172.902 1.00 218.10 ? 289 HIS A CG    1 
ATOM   2283 N  ND1   . HIS A 1 289 ? 170.026 158.814 172.921 1.00 218.10 ? 289 HIS A ND1   1 
ATOM   2284 C  CD2   . HIS A 1 289 ? 168.650 159.965 174.167 1.00 218.10 ? 289 HIS A CD2   1 
ATOM   2285 C  CE1   . HIS A 1 289 ? 170.522 158.821 174.146 1.00 218.10 ? 289 HIS A CE1   1 
ATOM   2286 N  NE2   . HIS A 1 289 ? 169.706 159.515 174.920 1.00 218.10 ? 289 HIS A NE2   1 
ATOM   2287 N  N     . ARG A 1 290 ? 165.717 157.648 172.633 1.00 212.42 ? 290 ARG A N     1 
ATOM   2288 C  CA    . ARG A 1 290 ? 165.160 156.738 173.631 1.00 212.42 ? 290 ARG A CA    1 
ATOM   2289 C  C     . ARG A 1 290 ? 165.089 155.312 173.094 1.00 212.42 ? 290 ARG A C     1 
ATOM   2290 O  O     . ARG A 1 290 ? 165.454 154.353 173.790 1.00 212.42 ? 290 ARG A O     1 
ATOM   2291 C  CB    . ARG A 1 290 ? 163.775 157.220 174.065 1.00 212.42 ? 290 ARG A CB    1 
ATOM   2292 C  CG    . ARG A 1 290 ? 163.064 156.296 175.045 1.00 212.42 ? 290 ARG A CG    1 
ATOM   2293 C  CD    . ARG A 1 290 ? 163.948 155.948 176.232 1.00 212.42 ? 290 ARG A CD    1 
ATOM   2294 N  NE    . ARG A 1 290 ? 164.428 157.137 176.926 1.00 212.42 ? 290 ARG A NE    1 
ATOM   2295 C  CZ    . ARG A 1 290 ? 163.772 157.752 177.899 1.00 212.42 ? 290 ARG A CZ    1 
ATOM   2296 N  NH1   . ARG A 1 290 ? 162.594 157.320 178.320 1.00 212.42 ? 290 ARG A NH1   1 
ATOM   2297 N  NH2   . ARG A 1 290 ? 164.310 158.829 178.465 1.00 212.42 ? 290 ARG A NH2   1 
ATOM   2298 N  N     . VAL A 1 291 ? 164.629 155.153 171.852 1.00 221.62 ? 291 VAL A N     1 
ATOM   2299 C  CA    . VAL A 1 291 ? 164.656 153.835 171.226 1.00 221.62 ? 291 VAL A CA    1 
ATOM   2300 C  C     . VAL A 1 291 ? 166.091 153.343 171.105 1.00 221.62 ? 291 VAL A C     1 
ATOM   2301 O  O     . VAL A 1 291 ? 166.363 152.144 171.243 1.00 221.62 ? 291 VAL A O     1 
ATOM   2302 C  CB    . VAL A 1 291 ? 163.951 153.877 169.856 1.00 221.62 ? 291 VAL A CB    1 
ATOM   2303 C  CG1   . VAL A 1 291 ? 164.044 152.528 169.159 1.00 221.62 ? 291 VAL A CG1   1 
ATOM   2304 C  CG2   . VAL A 1 291 ? 162.497 154.291 170.022 1.00 221.62 ? 291 VAL A CG2   1 
ATOM   2305 N  N     . ILE A 1 292 ? 167.031 154.258 170.870 1.00 232.47 ? 292 ILE A N     1 
ATOM   2306 C  CA    . ILE A 1 292 ? 168.433 153.886 170.715 1.00 232.47 ? 292 ILE A CA    1 
ATOM   2307 C  C     . ILE A 1 292 ? 168.984 153.332 172.023 1.00 232.47 ? 292 ILE A C     1 
ATOM   2308 O  O     . ILE A 1 292 ? 169.705 152.330 172.038 1.00 232.47 ? 292 ILE A O     1 
ATOM   2309 C  CB    . ILE A 1 292 ? 169.252 155.095 170.228 1.00 232.47 ? 292 ILE A CB    1 
ATOM   2310 C  CG1   . ILE A 1 292 ? 169.064 155.298 168.722 1.00 232.47 ? 292 ILE A CG1   1 
ATOM   2311 C  CG2   . ILE A 1 292 ? 170.718 154.929 170.580 1.00 232.47 ? 292 ILE A CG2   1 
ATOM   2312 C  CD1   . ILE A 1 292 ? 169.184 154.046 167.913 1.00 232.47 ? 292 ILE A CD1   1 
ATOM   2313 N  N     . LYS A 1 293 ? 168.661 153.983 173.142 1.00 244.63 ? 293 LYS A N     1 
ATOM   2314 C  CA    . LYS A 1 293 ? 169.154 153.504 174.431 1.00 244.63 ? 293 LYS A CA    1 
ATOM   2315 C  C     . LYS A 1 293 ? 168.464 152.209 174.844 1.00 244.63 ? 293 LYS A C     1 
ATOM   2316 O  O     . LYS A 1 293 ? 169.097 151.340 175.455 1.00 244.63 ? 293 LYS A O     1 
ATOM   2317 C  CB    . LYS A 1 293 ? 168.993 154.579 175.510 1.00 244.63 ? 293 LYS A CB    1 
ATOM   2318 C  CG    . LYS A 1 293 ? 167.566 154.918 175.890 1.00 244.63 ? 293 LYS A CG    1 
ATOM   2319 C  CD    . LYS A 1 293 ? 167.523 155.900 177.047 1.00 244.63 ? 293 LYS A CD    1 
ATOM   2320 C  CE    . LYS A 1 293 ? 168.083 157.251 176.636 1.00 244.63 ? 293 LYS A CE    1 
ATOM   2321 N  NZ    . LYS A 1 293 ? 168.074 158.228 177.759 1.00 244.63 ? 293 LYS A NZ    1 
ATOM   2322 N  N     . SER A 1 294 ? 167.183 152.045 174.504 1.00 254.47 ? 294 SER A N     1 
ATOM   2323 C  CA    . SER A 1 294 ? 166.547 150.748 174.716 1.00 254.47 ? 294 SER A CA    1 
ATOM   2324 C  C     . SER A 1 294 ? 167.251 149.660 173.911 1.00 254.47 ? 294 SER A C     1 
ATOM   2325 O  O     . SER A 1 294 ? 167.507 148.558 174.418 1.00 254.47 ? 294 SER A O     1 
ATOM   2326 C  CB    . SER A 1 294 ? 165.066 150.821 174.347 1.00 254.47 ? 294 SER A CB    1 
ATOM   2327 O  OG    . SER A 1 294 ? 164.296 151.319 175.427 1.00 254.47 ? 294 SER A OG    1 
ATOM   2328 N  N     . ARG A 1 295 ? 167.598 149.965 172.660 1.00 267.39 ? 295 ARG A N     1 
ATOM   2329 C  CA    . ARG A 1 295 ? 168.300 148.994 171.833 1.00 267.39 ? 295 ARG A CA    1 
ATOM   2330 C  C     . ARG A 1 295 ? 169.704 148.721 172.355 1.00 267.39 ? 295 ARG A C     1 
ATOM   2331 O  O     . ARG A 1 295 ? 170.202 147.603 172.228 1.00 267.39 ? 295 ARG A O     1 
ATOM   2332 C  CB    . ARG A 1 295 ? 168.350 149.466 170.381 1.00 267.39 ? 295 ARG A CB    1 
ATOM   2333 C  CG    . ARG A 1 295 ? 168.786 148.371 169.420 1.00 267.39 ? 295 ARG A CG    1 
ATOM   2334 C  CD    . ARG A 1 295 ? 168.160 147.043 169.806 1.00 267.39 ? 295 ARG A CD    1 
ATOM   2335 N  NE    . ARG A 1 295 ? 166.787 146.924 169.335 1.00 267.39 ? 295 ARG A NE    1 
ATOM   2336 C  CZ    . ARG A 1 295 ? 166.455 146.401 168.164 1.00 267.39 ? 295 ARG A CZ    1 
ATOM   2337 N  NH1   . ARG A 1 295 ? 167.369 145.903 167.349 1.00 267.39 ? 295 ARG A NH1   1 
ATOM   2338 N  NH2   . ARG A 1 295 ? 165.174 146.367 167.807 1.00 267.39 ? 295 ARG A NH2   1 
ATOM   2339 N  N     . ILE A 1 296 ? 170.366 149.723 172.936 1.00 267.85 ? 296 ILE A N     1 
ATOM   2340 C  CA    . ILE A 1 296 ? 171.708 149.471 173.453 1.00 267.85 ? 296 ILE A CA    1 
ATOM   2341 C  C     . ILE A 1 296 ? 171.632 148.649 174.734 1.00 267.85 ? 296 ILE A C     1 
ATOM   2342 O  O     . ILE A 1 296 ? 172.532 147.852 175.020 1.00 267.85 ? 296 ILE A O     1 
ATOM   2343 C  CB    . ILE A 1 296 ? 172.492 150.785 173.647 1.00 267.85 ? 296 ILE A CB    1 
ATOM   2344 C  CG1   . ILE A 1 296 ? 173.996 150.504 173.655 1.00 267.85 ? 296 ILE A CG1   1 
ATOM   2345 C  CG2   . ILE A 1 296 ? 172.121 151.474 174.945 1.00 267.85 ? 296 ILE A CG2   1 
ATOM   2346 C  CD1   . ILE A 1 296 ? 174.813 151.539 172.913 1.00 267.85 ? 296 ILE A CD1   1 
ATOM   2347 N  N     . ARG A 1 297 ? 170.556 148.798 175.512 1.00 266.56 ? 297 ARG A N     1 
ATOM   2348 C  CA    . ARG A 1 297 ? 170.330 147.879 176.624 1.00 266.56 ? 297 ARG A CA    1 
ATOM   2349 C  C     . ARG A 1 297 ? 170.117 146.457 176.118 1.00 266.56 ? 297 ARG A C     1 
ATOM   2350 O  O     . ARG A 1 297 ? 170.655 145.494 176.683 1.00 266.56 ? 297 ARG A O     1 
ATOM   2351 C  CB    . ARG A 1 297 ? 169.133 148.338 177.456 1.00 266.56 ? 297 ARG A CB    1 
ATOM   2352 C  CG    . ARG A 1 297 ? 169.340 149.661 178.174 1.00 266.56 ? 297 ARG A CG    1 
ATOM   2353 C  CD    . ARG A 1 297 ? 168.140 150.017 179.039 1.00 266.56 ? 297 ARG A CD    1 
ATOM   2354 N  NE    . ARG A 1 297 ? 166.928 150.222 178.255 1.00 266.56 ? 297 ARG A NE    1 
ATOM   2355 C  CZ    . ARG A 1 297 ? 165.928 149.355 178.181 1.00 266.56 ? 297 ARG A CZ    1 
ATOM   2356 N  NH1   . ARG A 1 297 ? 165.964 148.201 178.828 1.00 266.56 ? 297 ARG A NH1   1 
ATOM   2357 N  NH2   . ARG A 1 297 ? 164.864 149.652 177.440 1.00 266.56 ? 297 ARG A NH2   1 
ATOM   2358 N  N     . GLN A 1 298 ? 169.335 146.306 175.046 1.00 282.34 ? 298 GLN A N     1 
ATOM   2359 C  CA    . GLN A 1 298 ? 169.157 144.983 174.454 1.00 282.34 ? 298 GLN A CA    1 
ATOM   2360 C  C     . GLN A 1 298 ? 170.476 144.440 173.909 1.00 282.34 ? 298 GLN A C     1 
ATOM   2361 O  O     . GLN A 1 298 ? 170.726 143.230 173.955 1.00 282.34 ? 298 GLN A O     1 
ATOM   2362 C  CB    . GLN A 1 298 ? 168.090 145.033 173.360 1.00 282.34 ? 298 GLN A CB    1 
ATOM   2363 C  CG    . GLN A 1 298 ? 166.696 145.339 173.888 1.00 282.34 ? 298 GLN A CG    1 
ATOM   2364 C  CD    . GLN A 1 298 ? 165.867 146.170 172.928 1.00 282.34 ? 298 GLN A CD    1 
ATOM   2365 O  OE1   . GLN A 1 298 ? 165.920 145.974 171.715 1.00 282.34 ? 298 GLN A OE1   1 
ATOM   2366 N  NE2   . GLN A 1 298 ? 165.096 147.106 173.468 1.00 282.34 ? 298 GLN A NE2   1 
ATOM   2367 N  N     . LEU A 1 299 ? 171.331 145.321 173.386 1.00 289.25 ? 299 LEU A N     1 
ATOM   2368 C  CA    . LEU A 1 299 ? 172.655 144.910 172.928 1.00 289.25 ? 299 LEU A CA    1 
ATOM   2369 C  C     . LEU A 1 299 ? 173.520 144.444 174.091 1.00 289.25 ? 299 LEU A C     1 
ATOM   2370 O  O     . LEU A 1 299 ? 174.301 143.498 173.952 1.00 289.25 ? 299 LEU A O     1 
ATOM   2371 C  CB    . LEU A 1 299 ? 173.337 146.060 172.184 1.00 289.25 ? 299 LEU A CB    1 
ATOM   2372 C  CG    . LEU A 1 299 ? 172.759 146.476 170.831 1.00 289.25 ? 299 LEU A CG    1 
ATOM   2373 C  CD1   . LEU A 1 299 ? 173.586 147.595 170.213 1.00 289.25 ? 299 LEU A CD1   1 
ATOM   2374 C  CD2   . LEU A 1 299 ? 172.679 145.283 169.890 1.00 289.25 ? 299 LEU A CD2   1 
ATOM   2375 N  N     . GLU A 1 300 ? 173.416 145.119 175.237 1.00 290.79 ? 300 GLU A N     1 
ATOM   2376 C  CA    . GLU A 1 300 ? 174.114 144.657 176.433 1.00 290.79 ? 300 GLU A CA    1 
ATOM   2377 C  C     . GLU A 1 300 ? 173.616 143.281 176.852 1.00 290.79 ? 300 GLU A C     1 
ATOM   2378 O  O     . GLU A 1 300 ? 174.398 142.435 177.301 1.00 290.79 ? 300 GLU A O     1 
ATOM   2379 C  CB    . GLU A 1 300 ? 173.935 145.660 177.572 1.00 290.79 ? 300 GLU A CB    1 
ATOM   2380 C  CG    . GLU A 1 300 ? 174.536 147.029 177.303 1.00 290.79 ? 300 GLU A CG    1 
ATOM   2381 C  CD    . GLU A 1 300 ? 174.049 148.078 178.283 1.00 290.79 ? 300 GLU A CD    1 
ATOM   2382 O  OE1   . GLU A 1 300 ? 173.626 147.703 179.396 1.00 290.79 ? 300 GLU A OE1   1 
ATOM   2383 O  OE2   . GLU A 1 300 ? 174.086 149.278 177.938 1.00 290.79 ? 300 GLU A OE2   1 
ATOM   2384 N  N     . LYS A 1 301 ? 172.307 143.047 176.730 1.00 291.66 ? 301 LYS A N     1 
ATOM   2385 C  CA    . LYS A 1 301 ? 171.773 141.714 177.000 1.00 291.66 ? 301 LYS A CA    1 
ATOM   2386 C  C     . LYS A 1 301 ? 172.329 140.683 176.020 1.00 291.66 ? 301 LYS A C     1 
ATOM   2387 O  O     . LYS A 1 301 ? 172.684 139.567 176.415 1.00 291.66 ? 301 LYS A O     1 
ATOM   2388 C  CB    . LYS A 1 301 ? 170.245 141.733 176.941 1.00 291.66 ? 301 LYS A CB    1 
ATOM   2389 C  CG    . LYS A 1 301 ? 169.590 142.709 177.902 1.00 291.66 ? 301 LYS A CG    1 
ATOM   2390 C  CD    . LYS A 1 301 ? 168.163 143.018 177.478 1.00 291.66 ? 301 LYS A CD    1 
ATOM   2391 C  CE    . LYS A 1 301 ? 167.510 144.015 178.419 1.00 291.66 ? 301 LYS A CE    1 
ATOM   2392 N  NZ    . LYS A 1 301 ? 168.267 145.294 178.485 1.00 291.66 ? 301 LYS A NZ    1 
ATOM   2393 N  N     . ARG A 1 302 ? 172.411 141.043 174.739 1.00 294.69 ? 302 ARG A N     1 
ATOM   2394 C  CA    . ARG A 1 302 ? 172.816 140.099 173.701 1.00 294.69 ? 302 ARG A CA    1 
ATOM   2395 C  C     . ARG A 1 302 ? 174.311 139.802 173.720 1.00 294.69 ? 302 ARG A C     1 
ATOM   2396 O  O     . ARG A 1 302 ? 174.720 138.694 173.356 1.00 294.69 ? 302 ARG A O     1 
ATOM   2397 C  CB    . ARG A 1 302 ? 172.423 140.634 172.322 1.00 294.69 ? 302 ARG A CB    1 
ATOM   2398 C  CG    . ARG A 1 302 ? 170.928 140.656 172.051 1.00 294.69 ? 302 ARG A CG    1 
ATOM   2399 C  CD    . ARG A 1 302 ? 170.395 139.262 171.769 1.00 294.69 ? 302 ARG A CD    1 
ATOM   2400 N  NE    . ARG A 1 302 ? 168.976 139.280 171.435 1.00 294.69 ? 302 ARG A NE    1 
ATOM   2401 C  CZ    . ARG A 1 302 ? 167.996 139.135 172.315 1.00 294.69 ? 302 ARG A CZ    1 
ATOM   2402 N  NH1   . ARG A 1 302 ? 168.243 138.959 173.603 1.00 294.69 ? 302 ARG A NH1   1 
ATOM   2403 N  NH2   . ARG A 1 302 ? 166.735 139.167 171.893 1.00 294.69 ? 302 ARG A NH2   1 
ATOM   2404 N  N     . GLU A 1 303 ? 175.136 140.767 174.132 1.00 306.62 ? 303 GLU A N     1 
ATOM   2405 C  CA    . GLU A 1 303 ? 176.586 140.620 174.054 1.00 306.62 ? 303 GLU A CA    1 
ATOM   2406 C  C     . GLU A 1 303 ? 177.125 139.529 174.967 1.00 306.62 ? 303 GLU A C     1 
ATOM   2407 O  O     . GLU A 1 303 ? 178.290 139.147 174.822 1.00 306.62 ? 303 GLU A O     1 
ATOM   2408 C  CB    . GLU A 1 303 ? 177.264 141.953 174.382 1.00 306.62 ? 303 GLU A CB    1 
ATOM   2409 C  CG    . GLU A 1 303 ? 177.200 142.340 175.849 1.00 306.62 ? 303 GLU A CG    1 
ATOM   2410 C  CD    . GLU A 1 303 ? 177.658 143.764 176.096 1.00 306.62 ? 303 GLU A CD    1 
ATOM   2411 O  OE1   . GLU A 1 303 ? 178.295 144.351 175.196 1.00 306.62 ? 303 GLU A OE1   1 
ATOM   2412 O  OE2   . GLU A 1 303 ? 177.380 144.298 177.191 1.00 306.62 ? 303 GLU A OE2   1 
ATOM   2413 N  N     . SER A 1 304 ? 176.316 139.028 175.905 1.00 320.20 ? 304 SER A N     1 
ATOM   2414 C  CA    . SER A 1 304 ? 176.751 137.910 176.733 1.00 320.20 ? 304 SER A CA    1 
ATOM   2415 C  C     . SER A 1 304 ? 177.030 136.675 175.888 1.00 320.20 ? 304 SER A C     1 
ATOM   2416 O  O     . SER A 1 304 ? 177.963 135.915 176.173 1.00 320.20 ? 304 SER A O     1 
ATOM   2417 C  CB    . SER A 1 304 ? 175.697 137.608 177.800 1.00 320.20 ? 304 SER A CB    1 
ATOM   2418 O  OG    . SER A 1 304 ? 174.443 137.319 177.207 1.00 320.20 ? 304 SER A OG    1 
ATOM   2419 N  N     . GLU A 1 305 ? 176.230 136.456 174.840 1.00 315.62 ? 305 GLU A N     1 
ATOM   2420 C  CA    . GLU A 1 305 ? 176.388 135.299 173.952 1.00 315.62 ? 305 GLU A CA    1 
ATOM   2421 C  C     . GLU A 1 305 ? 176.276 135.793 172.510 1.00 315.62 ? 305 GLU A C     1 
ATOM   2422 O  O     . GLU A 1 305 ? 175.175 135.921 171.969 1.00 315.62 ? 305 GLU A O     1 
ATOM   2423 C  CB    . GLU A 1 305 ? 175.352 134.224 174.262 1.00 315.62 ? 305 GLU A CB    1 
ATOM   2424 C  CG    . GLU A 1 305 ? 175.627 133.443 175.537 1.00 315.62 ? 305 GLU A CG    1 
ATOM   2425 C  CD    . GLU A 1 305 ? 175.098 134.141 176.774 1.00 315.62 ? 305 GLU A CD    1 
ATOM   2426 O  OE1   . GLU A 1 305 ? 174.015 134.761 176.691 1.00 315.62 ? 305 GLU A OE1   1 
ATOM   2427 O  OE2   . GLU A 1 305 ? 175.763 134.074 177.828 1.00 315.62 ? 305 GLU A OE2   1 
ATOM   2428 N  N     . THR A 1 306 ? 177.424 136.068 171.895 1.00 302.12 ? 306 THR A N     1 
ATOM   2429 C  CA    . THR A 1 306 ? 177.466 136.481 170.498 1.00 302.12 ? 306 THR A CA    1 
ATOM   2430 C  C     . THR A 1 306 ? 178.834 136.139 169.925 1.00 302.12 ? 306 THR A C     1 
ATOM   2431 O  O     . THR A 1 306 ? 179.824 136.054 170.657 1.00 302.12 ? 306 THR A O     1 
ATOM   2432 C  CB    . THR A 1 306 ? 177.178 137.980 170.339 1.00 302.12 ? 306 THR A CB    1 
ATOM   2433 O  OG1   . THR A 1 306 ? 177.167 138.323 168.947 1.00 302.12 ? 306 THR A OG1   1 
ATOM   2434 C  CG2   . THR A 1 306 ? 178.232 138.812 171.056 1.00 302.12 ? 306 THR A CG2   1 
ATOM   2435 N  N     . ALA A 1 307 ? 178.874 135.935 168.612 1.00 305.80 ? 307 ALA A N     1 
ATOM   2436 C  CA    . ALA A 1 307 ? 180.124 135.622 167.940 1.00 305.80 ? 307 ALA A CA    1 
ATOM   2437 C  C     . ALA A 1 307 ? 180.864 136.905 167.562 1.00 305.80 ? 307 ALA A C     1 
ATOM   2438 O  O     . ALA A 1 307 ? 180.440 138.020 167.881 1.00 305.80 ? 307 ALA A O     1 
ATOM   2439 C  CB    . ALA A 1 307 ? 179.874 134.758 166.705 1.00 305.80 ? 307 ALA A CB    1 
ATOM   2440 N  N     . GLU A 1 308 ? 181.991 136.734 166.868 1.00 304.27 ? 308 GLU A N     1 
ATOM   2441 C  CA    . GLU A 1 308 ? 182.885 137.861 166.619 1.00 304.27 ? 308 GLU A CA    1 
ATOM   2442 C  C     . GLU A 1 308 ? 182.311 138.826 165.584 1.00 304.27 ? 308 GLU A C     1 
ATOM   2443 O  O     . GLU A 1 308 ? 182.348 140.044 165.779 1.00 304.27 ? 308 GLU A O     1 
ATOM   2444 C  CB    . GLU A 1 308 ? 184.267 137.356 166.193 1.00 304.27 ? 308 GLU A CB    1 
ATOM   2445 C  CG    . GLU A 1 308 ? 184.284 136.426 164.985 1.00 304.27 ? 308 GLU A CG    1 
ATOM   2446 C  CD    . GLU A 1 308 ? 183.944 134.990 165.339 1.00 304.27 ? 308 GLU A CD    1 
ATOM   2447 O  OE1   . GLU A 1 308 ? 183.750 134.701 166.538 1.00 304.27 ? 308 GLU A OE1   1 
ATOM   2448 O  OE2   . GLU A 1 308 ? 183.870 134.152 164.416 1.00 304.27 ? 308 GLU A OE2   1 
ATOM   2449 N  N     . GLU A 1 309 ? 181.771 138.305 164.478 1.00 304.98 ? 309 GLU A N     1 
ATOM   2450 C  CA    . GLU A 1 309 ? 181.346 139.184 163.391 1.00 304.98 ? 309 GLU A CA    1 
ATOM   2451 C  C     . GLU A 1 309 ? 180.131 140.019 163.790 1.00 304.98 ? 309 GLU A C     1 
ATOM   2452 O  O     . GLU A 1 309 ? 180.090 141.235 163.547 1.00 304.98 ? 309 GLU A O     1 
ATOM   2453 C  CB    . GLU A 1 309 ? 181.064 138.364 162.126 1.00 304.98 ? 309 GLU A CB    1 
ATOM   2454 C  CG    . GLU A 1 309 ? 179.969 137.310 162.250 1.00 304.98 ? 309 GLU A CG    1 
ATOM   2455 C  CD    . GLU A 1 309 ? 180.469 136.001 162.828 1.00 304.98 ? 309 GLU A CD    1 
ATOM   2456 O  OE1   . GLU A 1 309 ? 181.650 135.935 163.226 1.00 304.98 ? 309 GLU A OE1   1 
ATOM   2457 O  OE2   . GLU A 1 309 ? 179.679 135.035 162.887 1.00 304.98 ? 309 GLU A OE2   1 
ATOM   2458 N  N     . LEU A 1 310 ? 179.133 139.382 164.412 1.00 297.80 ? 310 LEU A N     1 
ATOM   2459 C  CA    . LEU A 1 310 ? 177.948 140.114 164.846 1.00 297.80 ? 310 LEU A CA    1 
ATOM   2460 C  C     . LEU A 1 310 ? 178.297 141.128 165.925 1.00 297.80 ? 310 LEU A C     1 
ATOM   2461 O  O     . LEU A 1 310 ? 177.776 142.248 165.922 1.00 297.80 ? 310 LEU A O     1 
ATOM   2462 C  CB    . LEU A 1 310 ? 176.865 139.150 165.336 1.00 297.80 ? 310 LEU A CB    1 
ATOM   2463 C  CG    . LEU A 1 310 ? 176.596 137.862 164.550 1.00 297.80 ? 310 LEU A CG    1 
ATOM   2464 C  CD1   . LEU A 1 310 ? 177.502 136.725 164.985 1.00 297.80 ? 310 LEU A CD1   1 
ATOM   2465 C  CD2   . LEU A 1 310 ? 175.136 137.459 164.682 1.00 297.80 ? 310 LEU A CD2   1 
ATOM   2466 N  N     . ARG A 1 311 ? 179.188 140.764 166.848 1.00 290.87 ? 311 ARG A N     1 
ATOM   2467 C  CA    . ARG A 1 311 ? 179.594 141.719 167.871 1.00 290.87 ? 311 ARG A CA    1 
ATOM   2468 C  C     . ARG A 1 311 ? 180.382 142.879 167.273 1.00 290.87 ? 311 ARG A C     1 
ATOM   2469 O  O     . ARG A 1 311 ? 180.262 144.011 167.750 1.00 290.87 ? 311 ARG A O     1 
ATOM   2470 C  CB    . ARG A 1 311 ? 180.390 141.013 168.971 1.00 290.87 ? 311 ARG A CB    1 
ATOM   2471 C  CG    . ARG A 1 311 ? 181.897 140.995 168.788 1.00 290.87 ? 311 ARG A CG    1 
ATOM   2472 C  CD    . ARG A 1 311 ? 182.580 140.419 170.015 1.00 290.87 ? 311 ARG A CD    1 
ATOM   2473 N  NE    . ARG A 1 311 ? 182.281 139.003 170.185 1.00 290.87 ? 311 ARG A NE    1 
ATOM   2474 C  CZ    . ARG A 1 311 ? 182.357 138.353 171.338 1.00 290.87 ? 311 ARG A CZ    1 
ATOM   2475 N  NH1   . ARG A 1 311 ? 182.720 138.965 172.453 1.00 290.87 ? 311 ARG A NH1   1 
ATOM   2476 N  NH2   . ARG A 1 311 ? 182.060 137.057 171.373 1.00 290.87 ? 311 ARG A NH2   1 
ATOM   2477 N  N     . THR A 1 312 ? 181.154 142.637 166.211 1.00 291.41 ? 312 THR A N     1 
ATOM   2478 C  CA    . THR A 1 312 ? 181.884 143.731 165.574 1.00 291.41 ? 312 THR A CA    1 
ATOM   2479 C  C     . THR A 1 312 ? 180.934 144.698 164.876 1.00 291.41 ? 312 THR A C     1 
ATOM   2480 O  O     . THR A 1 312 ? 181.065 145.920 165.020 1.00 291.41 ? 312 THR A O     1 
ATOM   2481 C  CB    . THR A 1 312 ? 182.917 143.190 164.584 1.00 291.41 ? 312 THR A CB    1 
ATOM   2482 O  OG1   . THR A 1 312 ? 182.305 142.218 163.727 1.00 291.41 ? 312 THR A OG1   1 
ATOM   2483 C  CG2   . THR A 1 312 ? 184.100 142.571 165.317 1.00 291.41 ? 312 THR A CG2   1 
ATOM   2484 N  N     . ILE A 1 313 ? 179.973 144.175 164.108 1.00 287.36 ? 313 ILE A N     1 
ATOM   2485 C  CA    . ILE A 1 313 ? 179.037 145.079 163.438 1.00 287.36 ? 313 ILE A CA    1 
ATOM   2486 C  C     . ILE A 1 313 ? 178.172 145.795 164.467 1.00 287.36 ? 313 ILE A C     1 
ATOM   2487 O  O     . ILE A 1 313 ? 177.806 146.965 164.290 1.00 287.36 ? 313 ILE A O     1 
ATOM   2488 C  CB    . ILE A 1 313 ? 178.183 144.341 162.388 1.00 287.36 ? 313 ILE A CB    1 
ATOM   2489 C  CG1   . ILE A 1 313 ? 177.674 143.008 162.920 1.00 287.36 ? 313 ILE A CG1   1 
ATOM   2490 C  CG2   . ILE A 1 313 ? 178.981 144.135 161.107 1.00 287.36 ? 313 ILE A CG2   1 
ATOM   2491 C  CD1   . ILE A 1 313 ? 176.930 142.183 161.891 1.00 287.36 ? 313 ILE A CD1   1 
ATOM   2492 N  N     . ARG A 1 314 ? 177.836 145.109 165.566 1.00 274.01 ? 314 ARG A N     1 
ATOM   2493 C  CA    . ARG A 1 314 ? 177.123 145.762 166.655 1.00 274.01 ? 314 ARG A CA    1 
ATOM   2494 C  C     . ARG A 1 314 ? 177.958 146.870 167.282 1.00 274.01 ? 314 ARG A C     1 
ATOM   2495 O  O     . ARG A 1 314 ? 177.413 147.906 167.663 1.00 274.01 ? 314 ARG A O     1 
ATOM   2496 C  CB    . ARG A 1 314 ? 176.716 144.730 167.708 1.00 274.01 ? 314 ARG A CB    1 
ATOM   2497 C  CG    . ARG A 1 314 ? 176.692 145.258 169.134 1.00 274.01 ? 314 ARG A CG    1 
ATOM   2498 C  CD    . ARG A 1 314 ? 176.814 144.135 170.150 1.00 274.01 ? 314 ARG A CD    1 
ATOM   2499 N  NE    . ARG A 1 314 ? 178.178 143.631 170.263 1.00 274.01 ? 314 ARG A NE    1 
ATOM   2500 C  CZ    . ARG A 1 314 ? 179.175 144.285 170.844 1.00 274.01 ? 314 ARG A CZ    1 
ATOM   2501 N  NH1   . ARG A 1 314 ? 178.999 145.480 171.384 1.00 274.01 ? 314 ARG A NH1   1 
ATOM   2502 N  NH2   . ARG A 1 314 ? 180.380 143.723 170.888 1.00 274.01 ? 314 ARG A NH2   1 
ATOM   2503 N  N     . GLU A 1 315 ? 179.274 146.677 167.394 1.00 270.40 ? 315 GLU A N     1 
ATOM   2504 C  CA    . GLU A 1 315 ? 180.138 147.735 167.912 1.00 270.40 ? 315 GLU A CA    1 
ATOM   2505 C  C     . GLU A 1 315 ? 180.187 148.931 166.967 1.00 270.40 ? 315 GLU A C     1 
ATOM   2506 O  O     . GLU A 1 315 ? 180.181 150.084 167.415 1.00 270.40 ? 315 GLU A O     1 
ATOM   2507 C  CB    . GLU A 1 315 ? 181.542 147.185 168.157 1.00 270.40 ? 315 GLU A CB    1 
ATOM   2508 C  CG    . GLU A 1 315 ? 181.717 146.530 169.514 1.00 270.40 ? 315 GLU A CG    1 
ATOM   2509 C  CD    . GLU A 1 315 ? 182.672 145.355 169.471 1.00 270.40 ? 315 GLU A CD    1 
ATOM   2510 O  OE1   . GLU A 1 315 ? 183.245 145.094 168.392 1.00 270.40 ? 315 GLU A OE1   1 
ATOM   2511 O  OE2   . GLU A 1 315 ? 182.849 144.692 170.514 1.00 270.40 ? 315 GLU A OE2   1 
ATOM   2512 N  N     . LEU A 1 316 ? 180.253 148.679 165.658 1.00 266.92 ? 316 LEU A N     1 
ATOM   2513 C  CA    . LEU A 1 316 ? 180.200 149.791 164.709 1.00 266.92 ? 316 LEU A CA    1 
ATOM   2514 C  C     . LEU A 1 316 ? 178.883 150.550 164.830 1.00 266.92 ? 316 LEU A C     1 
ATOM   2515 O  O     . LEU A 1 316 ? 178.868 151.785 164.879 1.00 266.92 ? 316 LEU A O     1 
ATOM   2516 C  CB    . LEU A 1 316 ? 180.398 149.301 163.273 1.00 266.92 ? 316 LEU A CB    1 
ATOM   2517 C  CG    . LEU A 1 316 ? 181.345 148.143 162.960 1.00 266.92 ? 316 LEU A CG    1 
ATOM   2518 C  CD1   . LEU A 1 316 ? 181.421 147.911 161.460 1.00 266.92 ? 316 LEU A CD1   1 
ATOM   2519 C  CD2   . LEU A 1 316 ? 182.732 148.409 163.527 1.00 266.92 ? 316 LEU A CD2   1 
ATOM   2520 N  N     . LEU A 1 317 ? 177.769 149.822 164.904 1.00 252.09 ? 317 LEU A N     1 
ATOM   2521 C  CA    . LEU A 1 317 ? 176.470 150.469 165.053 1.00 252.09 ? 317 LEU A CA    1 
ATOM   2522 C  C     . LEU A 1 317 ? 176.357 151.175 166.403 1.00 252.09 ? 317 LEU A C     1 
ATOM   2523 O  O     . LEU A 1 317 ? 175.665 152.195 166.522 1.00 252.09 ? 317 LEU A O     1 
ATOM   2524 C  CB    . LEU A 1 317 ? 175.378 149.419 164.840 1.00 252.09 ? 317 LEU A CB    1 
ATOM   2525 C  CG    . LEU A 1 317 ? 173.893 149.748 164.739 1.00 252.09 ? 317 LEU A CG    1 
ATOM   2526 C  CD1   . LEU A 1 317 ? 173.494 149.867 163.284 1.00 252.09 ? 317 LEU A CD1   1 
ATOM   2527 C  CD2   . LEU A 1 317 ? 173.106 148.619 165.380 1.00 252.09 ? 317 LEU A CD2   1 
ATOM   2528 N  N     . GLN A 1 318 ? 177.064 150.669 167.417 1.00 248.13 ? 318 GLN A N     1 
ATOM   2529 C  CA    . GLN A 1 318 ? 177.170 151.360 168.696 1.00 248.13 ? 318 GLN A CA    1 
ATOM   2530 C  C     . GLN A 1 318 ? 177.880 152.694 168.535 1.00 248.13 ? 318 GLN A C     1 
ATOM   2531 O  O     . GLN A 1 318 ? 177.462 153.703 169.112 1.00 248.13 ? 318 GLN A O     1 
ATOM   2532 C  CB    . GLN A 1 318 ? 177.908 150.476 169.701 1.00 248.13 ? 318 GLN A CB    1 
ATOM   2533 C  CG    . GLN A 1 318 ? 176.996 149.701 170.633 1.00 248.13 ? 318 GLN A CG    1 
ATOM   2534 C  CD    . GLN A 1 318 ? 177.658 148.456 171.189 1.00 248.13 ? 318 GLN A CD    1 
ATOM   2535 O  OE1   . GLN A 1 318 ? 178.829 148.188 170.918 1.00 248.13 ? 318 GLN A OE1   1 
ATOM   2536 N  NE2   . GLN A 1 318 ? 176.909 147.685 171.969 1.00 248.13 ? 318 GLN A NE2   1 
ATOM   2537 N  N     . SER A 1 319 ? 178.963 152.712 167.758 1.00 235.43 ? 319 SER A N     1 
ATOM   2538 C  CA    . SER A 1 319 ? 179.623 153.972 167.439 1.00 235.43 ? 319 SER A CA    1 
ATOM   2539 C  C     . SER A 1 319 ? 178.688 154.912 166.690 1.00 235.43 ? 319 SER A C     1 
ATOM   2540 O  O     . SER A 1 319 ? 178.743 156.133 166.885 1.00 235.43 ? 319 SER A O     1 
ATOM   2541 C  CB    . SER A 1 319 ? 180.889 153.708 166.623 1.00 235.43 ? 319 SER A CB    1 
ATOM   2542 O  OG    . SER A 1 319 ? 180.591 153.610 165.241 1.00 235.43 ? 319 SER A OG    1 
ATOM   2543 N  N     . ILE A 1 320 ? 177.826 154.366 165.830 1.00 241.17 ? 320 ILE A N     1 
ATOM   2544 C  CA    . ILE A 1 320 ? 176.834 155.201 165.151 1.00 241.17 ? 320 ILE A CA    1 
ATOM   2545 C  C     . ILE A 1 320 ? 175.886 155.841 166.162 1.00 241.17 ? 320 ILE A C     1 
ATOM   2546 O  O     . ILE A 1 320 ? 175.580 157.036 166.074 1.00 241.17 ? 320 ILE A O     1 
ATOM   2547 C  CB    . ILE A 1 320 ? 176.063 154.409 164.076 1.00 241.17 ? 320 ILE A CB    1 
ATOM   2548 C  CG1   . ILE A 1 320 ? 176.977 153.510 163.231 1.00 241.17 ? 320 ILE A CG1   1 
ATOM   2549 C  CG2   . ILE A 1 320 ? 175.282 155.360 163.176 1.00 241.17 ? 320 ILE A CG2   1 
ATOM   2550 C  CD1   . ILE A 1 320 ? 178.312 154.135 162.828 1.00 241.17 ? 320 ILE A CD1   1 
ATOM   2551 N  N     . PHE A 1 321 ? 175.396 155.059 167.135 1.00 225.26 ? 321 PHE A N     1 
ATOM   2552 C  CA    . PHE A 1 321 ? 174.558 155.691 168.155 1.00 225.26 ? 321 PHE A CA    1 
ATOM   2553 C  C     . PHE A 1 321 ? 175.335 156.716 168.965 1.00 225.26 ? 321 PHE A C     1 
ATOM   2554 O  O     . PHE A 1 321 ? 174.765 157.722 169.393 1.00 225.26 ? 321 PHE A O     1 
ATOM   2555 C  CB    . PHE A 1 321 ? 173.920 154.708 169.141 1.00 225.26 ? 321 PHE A CB    1 
ATOM   2556 C  CG    . PHE A 1 321 ? 173.493 153.405 168.556 1.00 225.26 ? 321 PHE A CG    1 
ATOM   2557 C  CD1   . PHE A 1 321 ? 172.434 153.345 167.678 1.00 225.26 ? 321 PHE A CD1   1 
ATOM   2558 C  CD2   . PHE A 1 321 ? 174.025 152.224 169.030 1.00 225.26 ? 321 PHE A CD2   1 
ATOM   2559 C  CE1   . PHE A 1 321 ? 172.006 152.137 167.178 1.00 225.26 ? 321 PHE A CE1   1 
ATOM   2560 C  CE2   . PHE A 1 321 ? 173.599 151.011 168.540 1.00 225.26 ? 321 PHE A CE2   1 
ATOM   2561 C  CZ    . PHE A 1 321 ? 172.581 150.970 167.623 1.00 225.26 ? 321 PHE A CZ    1 
ATOM   2562 N  N     . GLU A 1 322 ? 176.620 156.463 169.216 1.00 218.01 ? 322 GLU A N     1 
ATOM   2563 C  CA    . GLU A 1 322 ? 177.427 157.444 169.933 1.00 218.01 ? 322 GLU A CA    1 
ATOM   2564 C  C     . GLU A 1 322 ? 177.494 158.755 169.164 1.00 218.01 ? 322 GLU A C     1 
ATOM   2565 O  O     . GLU A 1 322 ? 177.360 159.834 169.748 1.00 218.01 ? 322 GLU A O     1 
ATOM   2566 C  CB    . GLU A 1 322 ? 178.830 156.894 170.183 1.00 218.01 ? 322 GLU A CB    1 
ATOM   2567 C  CG    . GLU A 1 322 ? 178.865 155.680 171.093 1.00 218.01 ? 322 GLU A CG    1 
ATOM   2568 C  CD    . GLU A 1 322 ? 180.146 154.886 170.950 1.00 218.01 ? 322 GLU A CD    1 
ATOM   2569 O  OE1   . GLU A 1 322 ? 181.007 155.287 170.139 1.00 218.01 ? 322 GLU A OE1   1 
ATOM   2570 O  OE2   . GLU A 1 322 ? 180.290 153.860 171.645 1.00 218.01 ? 322 GLU A OE2   1 
ATOM   2571 N  N     . GLN A 1 323 ? 177.681 158.677 167.845 1.00 214.40 ? 323 GLN A N     1 
ATOM   2572 C  CA    . GLN A 1 323 ? 177.671 159.883 167.022 1.00 214.40 ? 323 GLN A CA    1 
ATOM   2573 C  C     . GLN A 1 323 ? 176.308 160.566 167.067 1.00 214.40 ? 323 GLN A C     1 
ATOM   2574 O  O     . GLN A 1 323 ? 176.222 161.799 167.139 1.00 214.40 ? 323 GLN A O     1 
ATOM   2575 C  CB    . GLN A 1 323 ? 178.047 159.541 165.582 1.00 214.40 ? 323 GLN A CB    1 
ATOM   2576 C  CG    . GLN A 1 323 ? 179.413 158.898 165.428 1.00 214.40 ? 323 GLN A CG    1 
ATOM   2577 C  CD    . GLN A 1 323 ? 179.439 157.847 164.337 1.00 214.40 ? 323 GLN A CD    1 
ATOM   2578 O  OE1   . GLN A 1 323 ? 178.670 157.912 163.378 1.00 214.40 ? 323 GLN A OE1   1 
ATOM   2579 N  NE2   . GLN A 1 323 ? 180.323 156.866 164.481 1.00 214.40 ? 323 GLN A NE2   1 
ATOM   2580 N  N     . ILE A 1 324 ? 175.231 159.779 167.016 1.00 204.63 ? 324 ILE A N     1 
ATOM   2581 C  CA    . ILE A 1 324 ? 173.886 160.351 167.054 1.00 204.63 ? 324 ILE A CA    1 
ATOM   2582 C  C     . ILE A 1 324 ? 173.667 161.103 168.359 1.00 204.63 ? 324 ILE A C     1 
ATOM   2583 O  O     . ILE A 1 324 ? 173.142 162.222 168.373 1.00 204.63 ? 324 ILE A O     1 
ATOM   2584 C  CB    . ILE A 1 324 ? 172.827 159.252 166.853 1.00 204.63 ? 324 ILE A CB    1 
ATOM   2585 C  CG1   . ILE A 1 324 ? 172.927 158.657 165.447 1.00 204.63 ? 324 ILE A CG1   1 
ATOM   2586 C  CG2   . ILE A 1 324 ? 171.430 159.804 167.100 1.00 204.63 ? 324 ILE A CG2   1 
ATOM   2587 C  CD1   . ILE A 1 324 ? 172.463 157.220 165.362 1.00 204.63 ? 324 ILE A CD1   1 
ATOM   2588 N  N     . ILE A 1 325 ? 174.073 160.501 169.477 1.00 213.08 ? 325 ILE A N     1 
ATOM   2589 C  CA    . ILE A 1 325 ? 173.909 161.142 170.777 1.00 213.08 ? 325 ILE A CA    1 
ATOM   2590 C  C     . ILE A 1 325 ? 174.803 162.372 170.884 1.00 213.08 ? 325 ILE A C     1 
ATOM   2591 O  O     . ILE A 1 325 ? 174.424 163.380 171.490 1.00 213.08 ? 325 ILE A O     1 
ATOM   2592 C  CB    . ILE A 1 325 ? 174.186 160.133 171.907 1.00 213.08 ? 325 ILE A CB    1 
ATOM   2593 C  CG1   . ILE A 1 325 ? 173.198 158.969 171.832 1.00 213.08 ? 325 ILE A CG1   1 
ATOM   2594 C  CG2   . ILE A 1 325 ? 174.091 160.805 173.266 1.00 213.08 ? 325 ILE A CG2   1 
ATOM   2595 C  CD1   . ILE A 1 325 ? 173.693 157.705 172.502 1.00 213.08 ? 325 ILE A CD1   1 
ATOM   2596 N  N     . ASN A 1 326 ? 176.001 162.312 170.298 1.00 222.88 ? 326 ASN A N     1 
ATOM   2597 C  CA    . ASN A 1 326 ? 176.883 163.473 170.303 1.00 222.88 ? 326 ASN A CA    1 
ATOM   2598 C  C     . ASN A 1 326 ? 176.250 164.646 169.569 1.00 222.88 ? 326 ASN A C     1 
ATOM   2599 O  O     . ASN A 1 326 ? 176.317 165.790 170.033 1.00 222.88 ? 326 ASN A O     1 
ATOM   2600 C  CB    . ASN A 1 326 ? 178.229 163.111 169.679 1.00 222.88 ? 326 ASN A CB    1 
ATOM   2601 C  CG    . ASN A 1 326 ? 179.150 162.404 170.651 1.00 222.88 ? 326 ASN A CG    1 
ATOM   2602 O  OD1   . ASN A 1 326 ? 180.054 163.013 171.223 1.00 222.88 ? 326 ASN A OD1   1 
ATOM   2603 N  ND2   . ASN A 1 326 ? 178.926 161.110 170.845 1.00 222.88 ? 326 ASN A ND2   1 
ATOM   2604 N  N     . VAL A 1 327 ? 175.631 164.382 168.417 1.00 221.66 ? 327 VAL A N     1 
ATOM   2605 C  CA    . VAL A 1 327 ? 174.936 165.448 167.698 1.00 221.66 ? 327 VAL A CA    1 
ATOM   2606 C  C     . VAL A 1 327 ? 173.718 165.915 168.486 1.00 221.66 ? 327 VAL A C     1 
ATOM   2607 O  O     . VAL A 1 327 ? 173.394 167.109 168.510 1.00 221.66 ? 327 VAL A O     1 
ATOM   2608 C  CB    . VAL A 1 327 ? 174.554 164.987 166.280 1.00 221.66 ? 327 VAL A CB    1 
ATOM   2609 C  CG1   . VAL A 1 327 ? 173.911 166.130 165.515 1.00 221.66 ? 327 VAL A CG1   1 
ATOM   2610 C  CG2   . VAL A 1 327 ? 175.782 164.486 165.539 1.00 221.66 ? 327 VAL A CG2   1 
ATOM   2611 N  N     . LEU A 1 328 ? 173.028 164.981 169.146 1.00 222.46 ? 328 LEU A N     1 
ATOM   2612 C  CA    . LEU A 1 328 ? 171.860 165.338 169.945 1.00 222.46 ? 328 LEU A CA    1 
ATOM   2613 C  C     . LEU A 1 328 ? 172.228 166.253 171.104 1.00 222.46 ? 328 LEU A C     1 
ATOM   2614 O  O     . LEU A 1 328 ? 171.419 167.098 171.506 1.00 222.46 ? 328 LEU A O     1 
ATOM   2615 C  CB    . LEU A 1 328 ? 171.174 164.073 170.464 1.00 222.46 ? 328 LEU A CB    1 
ATOM   2616 C  CG    . LEU A 1 328 ? 169.806 164.243 171.129 1.00 222.46 ? 328 LEU A CG    1 
ATOM   2617 C  CD1   . LEU A 1 328 ? 168.851 163.157 170.665 1.00 222.46 ? 328 LEU A CD1   1 
ATOM   2618 C  CD2   . LEU A 1 328 ? 169.933 164.230 172.645 1.00 222.46 ? 328 LEU A CD2   1 
ATOM   2619 N  N     . LYS A 1 329 ? 173.431 166.091 171.657 1.00 235.09 ? 329 LYS A N     1 
ATOM   2620 C  CA    . LYS A 1 329 ? 173.872 166.961 172.742 1.00 235.09 ? 329 LYS A CA    1 
ATOM   2621 C  C     . LYS A 1 329 ? 173.885 168.423 172.317 1.00 235.09 ? 329 LYS A C     1 
ATOM   2622 O  O     . LYS A 1 329 ? 173.622 169.310 173.136 1.00 235.09 ? 329 LYS A O     1 
ATOM   2623 C  CB    . LYS A 1 329 ? 175.258 166.541 173.229 1.00 235.09 ? 329 LYS A CB    1 
ATOM   2624 C  CG    . LYS A 1 329 ? 175.299 165.182 173.903 1.00 235.09 ? 329 LYS A CG    1 
ATOM   2625 C  CD    . LYS A 1 329 ? 176.681 164.561 173.795 1.00 235.09 ? 329 LYS A CD    1 
ATOM   2626 C  CE    . LYS A 1 329 ? 176.713 163.168 174.402 1.00 235.09 ? 329 LYS A CE    1 
ATOM   2627 N  NZ    . LYS A 1 329 ? 177.143 162.143 173.410 1.00 235.09 ? 329 LYS A NZ    1 
ATOM   2628 N  N     . ASN A 1 330 ? 174.192 168.693 171.046 1.00 235.48 ? 330 ASN A N     1 
ATOM   2629 C  CA    . ASN A 1 330 ? 174.173 170.066 170.556 1.00 235.48 ? 330 ASN A CA    1 
ATOM   2630 C  C     . ASN A 1 330 ? 172.764 170.647 170.584 1.00 235.48 ? 330 ASN A C     1 
ATOM   2631 O  O     . ASN A 1 330 ? 172.576 171.815 170.943 1.00 235.48 ? 330 ASN A O     1 
ATOM   2632 C  CB    . ASN A 1 330 ? 174.749 170.127 169.143 1.00 235.48 ? 330 ASN A CB    1 
ATOM   2633 C  CG    . ASN A 1 330 ? 174.907 171.548 168.641 1.00 235.48 ? 330 ASN A CG    1 
ATOM   2634 O  OD1   . ASN A 1 330 ? 175.164 172.467 169.417 1.00 235.48 ? 330 ASN A OD1   1 
ATOM   2635 N  ND2   . ASN A 1 330 ? 174.754 171.734 167.335 1.00 235.48 ? 330 ASN A ND2   1 
ATOM   2636 N  N     . LEU A 1 331 ? 171.763 169.851 170.210 1.00 241.61 ? 331 LEU A N     1 
ATOM   2637 C  CA    . LEU A 1 331 ? 170.378 170.311 170.143 1.00 241.61 ? 331 LEU A CA    1 
ATOM   2638 C  C     . LEU A 1 331 ? 169.551 169.827 171.329 1.00 241.61 ? 331 LEU A C     1 
ATOM   2639 O  O     . LEU A 1 331 ? 168.360 169.536 171.193 1.00 241.61 ? 331 LEU A O     1 
ATOM   2640 C  CB    . LEU A 1 331 ? 169.744 169.893 168.814 1.00 241.61 ? 331 LEU A CB    1 
ATOM   2641 C  CG    . LEU A 1 331 ? 169.748 168.463 168.244 1.00 241.61 ? 331 LEU A CG    1 
ATOM   2642 C  CD1   . LEU A 1 331 ? 169.134 167.406 169.155 1.00 241.61 ? 331 LEU A CD1   1 
ATOM   2643 C  CD2   . LEU A 1 331 ? 169.068 168.443 166.883 1.00 241.61 ? 331 LEU A CD2   1 
ATOM   2644 N  N     . GLU A 1 332 ? 170.151 169.774 172.517 1.00 266.87 ? 332 GLU A N     1 
ATOM   2645 C  CA    . GLU A 1 332 ? 169.436 169.310 173.699 1.00 266.87 ? 332 GLU A CA    1 
ATOM   2646 C  C     . GLU A 1 332 ? 168.409 170.350 174.126 1.00 266.87 ? 332 GLU A C     1 
ATOM   2647 O  O     . GLU A 1 332 ? 168.571 171.012 175.156 1.00 266.87 ? 332 GLU A O     1 
ATOM   2648 C  CB    . GLU A 1 332 ? 170.408 169.020 174.844 1.00 266.87 ? 332 GLU A CB    1 
ATOM   2649 C  CG    . GLU A 1 332 ? 170.714 167.547 175.048 1.00 266.87 ? 332 GLU A CG    1 
ATOM   2650 C  CD    . GLU A 1 332 ? 172.075 167.318 175.675 1.00 266.87 ? 332 GLU A CD    1 
ATOM   2651 O  OE1   . GLU A 1 332 ? 172.667 168.293 176.186 1.00 266.87 ? 332 GLU A OE1   1 
ATOM   2652 O  OE2   . GLU A 1 332 ? 172.554 166.166 175.658 1.00 266.87 ? 332 GLU A OE2   1 
ATOM   2653 N  N     . LYS A 1 333 ? 167.347 170.493 173.330 1.00 268.42 ? 333 LYS A N     1 
ATOM   2654 C  CA    . LYS A 1 333 ? 166.332 171.501 173.612 1.00 268.42 ? 333 LYS A CA    1 
ATOM   2655 C  C     . LYS A 1 333 ? 165.532 171.158 174.861 1.00 268.42 ? 333 LYS A C     1 
ATOM   2656 O  O     . LYS A 1 333 ? 164.970 172.056 175.498 1.00 268.42 ? 333 LYS A O     1 
ATOM   2657 C  CB    . LYS A 1 333 ? 165.405 171.650 172.409 1.00 268.42 ? 333 LYS A CB    1 
ATOM   2658 C  CG    . LYS A 1 333 ? 166.113 171.992 171.109 1.00 268.42 ? 333 LYS A CG    1 
ATOM   2659 C  CD    . LYS A 1 333 ? 165.147 171.934 169.939 1.00 268.42 ? 333 LYS A CD    1 
ATOM   2660 C  CE    . LYS A 1 333 ? 165.861 172.116 168.610 1.00 268.42 ? 333 LYS A CE    1 
ATOM   2661 N  NZ    . LYS A 1 333 ? 164.928 171.957 167.459 1.00 268.42 ? 333 LYS A NZ    1 
ATOM   2662 N  N     . LEU A 1 334 ? 165.455 169.873 175.217 1.00 267.31 ? 334 LEU A N     1 
ATOM   2663 C  CA    . LEU A 1 334 ? 164.820 169.498 176.476 1.00 267.31 ? 334 LEU A CA    1 
ATOM   2664 C  C     . LEU A 1 334 ? 165.588 170.068 177.662 1.00 267.31 ? 334 LEU A C     1 
ATOM   2665 O  O     . LEU A 1 334 ? 164.987 170.541 178.633 1.00 267.31 ? 334 LEU A O     1 
ATOM   2666 C  CB    . LEU A 1 334 ? 164.708 167.979 176.579 1.00 267.31 ? 334 LEU A CB    1 
ATOM   2667 C  CG    . LEU A 1 334 ? 164.030 167.451 177.844 1.00 267.31 ? 334 LEU A CG    1 
ATOM   2668 C  CD1   . LEU A 1 334 ? 162.926 166.480 177.482 1.00 267.31 ? 334 LEU A CD1   1 
ATOM   2669 C  CD2   . LEU A 1 334 ? 165.046 166.788 178.764 1.00 267.31 ? 334 LEU A CD2   1 
ATOM   2670 N  N     . GLN A 1 335 ? 166.922 170.026 177.601 1.00 295.04 ? 335 GLN A N     1 
ATOM   2671 C  CA    . GLN A 1 335 ? 167.728 170.701 178.610 1.00 295.04 ? 335 GLN A CA    1 
ATOM   2672 C  C     . GLN A 1 335 ? 167.565 172.213 178.527 1.00 295.04 ? 335 GLN A C     1 
ATOM   2673 O  O     . GLN A 1 335 ? 167.804 172.918 179.515 1.00 295.04 ? 335 GLN A O     1 
ATOM   2674 C  CB    . GLN A 1 335 ? 169.198 170.311 178.458 1.00 295.04 ? 335 GLN A CB    1 
ATOM   2675 C  CG    . GLN A 1 335 ? 169.626 169.149 179.340 1.00 295.04 ? 335 GLN A CG    1 
ATOM   2676 C  CD    . GLN A 1 335 ? 168.813 167.894 179.089 1.00 295.04 ? 335 GLN A CD    1 
ATOM   2677 O  OE1   . GLN A 1 335 ? 168.798 167.362 177.978 1.00 295.04 ? 335 GLN A OE1   1 
ATOM   2678 N  NE2   . GLN A 1 335 ? 168.132 167.411 180.122 1.00 295.04 ? 335 GLN A NE2   1 
ATOM   2679 N  N     . LYS A 1 336 ? 167.164 172.724 177.365 1.00 280.86 ? 336 LYS A N     1 
ATOM   2680 C  CA    . LYS A 1 336 ? 166.847 174.133 177.187 1.00 280.86 ? 336 LYS A CA    1 
ATOM   2681 C  C     . LYS A 1 336 ? 165.386 174.444 177.483 1.00 280.86 ? 336 LYS A C     1 
ATOM   2682 O  O     . LYS A 1 336 ? 164.958 175.587 177.289 1.00 280.86 ? 336 LYS A O     1 
ATOM   2683 C  CB    . LYS A 1 336 ? 167.191 174.575 175.760 1.00 280.86 ? 336 LYS A CB    1 
ATOM   2684 C  CG    . LYS A 1 336 ? 168.682 174.731 175.500 1.00 280.86 ? 336 LYS A CG    1 
ATOM   2685 C  CD    . LYS A 1 336 ? 169.069 174.155 174.146 1.00 280.86 ? 336 LYS A CD    1 
ATOM   2686 C  CE    . LYS A 1 336 ? 170.455 173.530 174.186 1.00 280.86 ? 336 LYS A CE    1 
ATOM   2687 N  NZ    . LYS A 1 336 ? 170.565 172.483 175.238 1.00 280.86 ? 336 LYS A NZ    1 
ATOM   2688 N  N     . ASN A 1 337 ? 164.617 173.449 177.933 1.00 285.34 ? 337 ASN A N     1 
ATOM   2689 C  CA    . ASN A 1 337 ? 163.210 173.613 178.307 1.00 285.34 ? 337 ASN A CA    1 
ATOM   2690 C  C     . ASN A 1 337 ? 162.352 174.073 177.131 1.00 285.34 ? 337 ASN A C     1 
ATOM   2691 O  O     . ASN A 1 337 ? 161.386 174.819 177.308 1.00 285.34 ? 337 ASN A O     1 
ATOM   2692 C  CB    . ASN A 1 337 ? 163.055 174.574 179.490 1.00 285.34 ? 337 ASN A CB    1 
ATOM   2693 C  CG    . ASN A 1 337 ? 161.794 174.312 180.291 1.00 285.34 ? 337 ASN A CG    1 
ATOM   2694 O  OD1   . ASN A 1 337 ? 161.327 173.178 180.381 1.00 285.34 ? 337 ASN A OD1   1 
ATOM   2695 N  ND2   . ASN A 1 337 ? 161.236 175.366 180.877 1.00 285.34 ? 337 ASN A ND2   1 
ATOM   2696 N  N     . ASN A 1 338 ? 162.695 173.634 175.916 1.00 261.48 ? 338 ASN A N     1 
ATOM   2697 C  CA    . ASN A 1 338 ? 161.879 173.874 174.723 1.00 261.48 ? 338 ASN A CA    1 
ATOM   2698 C  C     . ASN A 1 338 ? 161.706 172.535 174.011 1.00 261.48 ? 338 ASN A C     1 
ATOM   2699 O  O     . ASN A 1 338 ? 162.437 172.214 173.073 1.00 261.48 ? 338 ASN A O     1 
ATOM   2700 C  CB    . ASN A 1 338 ? 162.518 174.927 173.817 1.00 261.48 ? 338 ASN A CB    1 
ATOM   2701 C  CG    . ASN A 1 338 ? 161.543 175.488 172.799 1.00 261.48 ? 338 ASN A CG    1 
ATOM   2702 O  OD1   . ASN A 1 338 ? 160.927 174.743 172.036 1.00 261.48 ? 338 ASN A OD1   1 
ATOM   2703 N  ND2   . ASN A 1 338 ? 161.399 176.808 172.783 1.00 261.48 ? 338 ASN A ND2   1 
ATOM   2704 N  N     . SER A 1 339 ? 160.715 171.758 174.449 1.00 248.76 ? 339 SER A N     1 
ATOM   2705 C  CA    . SER A 1 339 ? 160.488 170.443 173.868 1.00 248.76 ? 339 SER A CA    1 
ATOM   2706 C  C     . SER A 1 339 ? 159.698 170.502 172.567 1.00 248.76 ? 339 SER A C     1 
ATOM   2707 O  O     . SER A 1 339 ? 159.683 169.516 171.823 1.00 248.76 ? 339 SER A O     1 
ATOM   2708 C  CB    . SER A 1 339 ? 159.764 169.542 174.870 1.00 248.76 ? 339 SER A CB    1 
ATOM   2709 O  OG    . SER A 1 339 ? 159.665 168.215 174.382 1.00 248.76 ? 339 SER A OG    1 
ATOM   2710 N  N     . VAL A 1 340 ? 159.051 171.631 172.279 1.00 224.60 ? 340 VAL A N     1 
ATOM   2711 C  CA    . VAL A 1 340 ? 158.195 171.724 171.100 1.00 224.60 ? 340 VAL A CA    1 
ATOM   2712 C  C     . VAL A 1 340 ? 159.024 171.694 169.820 1.00 224.60 ? 340 VAL A C     1 
ATOM   2713 O  O     . VAL A 1 340 ? 158.608 171.116 168.810 1.00 224.60 ? 340 VAL A O     1 
ATOM   2714 C  CB    . VAL A 1 340 ? 157.324 172.990 171.183 1.00 224.60 ? 340 VAL A CB    1 
ATOM   2715 C  CG1   . VAL A 1 340 ? 156.396 173.083 169.984 1.00 224.60 ? 340 VAL A CG1   1 
ATOM   2716 C  CG2   . VAL A 1 340 ? 156.529 173.002 172.480 1.00 224.60 ? 340 VAL A CG2   1 
ATOM   2717 N  N     . GLU A 1 341 ? 160.206 172.313 169.842 1.00 217.66 ? 341 GLU A N     1 
ATOM   2718 C  CA    . GLU A 1 341 ? 160.928 172.586 168.603 1.00 217.66 ? 341 GLU A CA    1 
ATOM   2719 C  C     . GLU A 1 341 ? 161.391 171.307 167.912 1.00 217.66 ? 341 GLU A C     1 
ATOM   2720 O  O     . GLU A 1 341 ? 161.154 171.121 166.713 1.00 217.66 ? 341 GLU A O     1 
ATOM   2721 C  CB    . GLU A 1 341 ? 162.115 173.505 168.887 1.00 217.66 ? 341 GLU A CB    1 
ATOM   2722 C  CG    . GLU A 1 341 ? 161.817 174.980 168.688 1.00 217.66 ? 341 GLU A CG    1 
ATOM   2723 C  CD    . GLU A 1 341 ? 162.603 175.864 169.633 1.00 217.66 ? 341 GLU A CD    1 
ATOM   2724 O  OE1   . GLU A 1 341 ? 163.769 175.531 169.931 1.00 217.66 ? 341 GLU A OE1   1 
ATOM   2725 O  OE2   . GLU A 1 341 ? 162.055 176.894 170.079 1.00 217.66 ? 341 GLU A OE2   1 
ATOM   2726 N  N     . PHE A 1 342 ? 162.057 170.410 168.645 1.00 210.89 ? 342 PHE A N     1 
ATOM   2727 C  CA    . PHE A 1 342 ? 162.716 169.290 167.980 1.00 210.89 ? 342 PHE A CA    1 
ATOM   2728 C  C     . PHE A 1 342 ? 161.743 168.211 167.518 1.00 210.89 ? 342 PHE A C     1 
ATOM   2729 O  O     . PHE A 1 342 ? 162.076 167.458 166.597 1.00 210.89 ? 342 PHE A O     1 
ATOM   2730 C  CB    . PHE A 1 342 ? 163.793 168.679 168.884 1.00 210.89 ? 342 PHE A CB    1 
ATOM   2731 C  CG    . PHE A 1 342 ? 163.292 168.215 170.226 1.00 210.89 ? 342 PHE A CG    1 
ATOM   2732 C  CD1   . PHE A 1 342 ? 162.636 167.002 170.362 1.00 210.89 ? 342 PHE A CD1   1 
ATOM   2733 C  CD2   . PHE A 1 342 ? 163.507 168.980 171.358 1.00 210.89 ? 342 PHE A CD2   1 
ATOM   2734 C  CE1   . PHE A 1 342 ? 162.190 166.573 171.599 1.00 210.89 ? 342 PHE A CE1   1 
ATOM   2735 C  CE2   . PHE A 1 342 ? 163.066 168.556 172.595 1.00 210.89 ? 342 PHE A CE2   1 
ATOM   2736 C  CZ    . PHE A 1 342 ? 162.404 167.352 172.716 1.00 210.89 ? 342 PHE A CZ    1 
ATOM   2737 N  N     . VAL A 1 343 ? 160.555 168.117 168.120 1.00 159.66 ? 343 VAL A N     1 
ATOM   2738 C  CA    . VAL A 1 343 ? 159.629 167.055 167.735 1.00 159.66 ? 343 VAL A CA    1 
ATOM   2739 C  C     . VAL A 1 343 ? 159.102 167.297 166.325 1.00 159.66 ? 343 VAL A C     1 
ATOM   2740 O  O     . VAL A 1 343 ? 159.209 168.392 165.760 1.00 159.66 ? 343 VAL A O     1 
ATOM   2741 C  CB    . VAL A 1 343 ? 158.473 166.931 168.741 1.00 159.66 ? 343 VAL A CB    1 
ATOM   2742 C  CG1   . VAL A 1 343 ? 159.006 166.872 170.159 1.00 159.66 ? 343 VAL A CG1   1 
ATOM   2743 C  CG2   . VAL A 1 343 ? 157.498 168.084 168.571 1.00 159.66 ? 343 VAL A CG2   1 
ATOM   2744 N  N     . SER A 1 344 ? 158.526 166.246 165.750 1.00 131.22 ? 344 SER A N     1 
ATOM   2745 C  CA    . SER A 1 344 ? 157.986 166.330 164.405 1.00 131.22 ? 344 SER A CA    1 
ATOM   2746 C  C     . SER A 1 344 ? 156.796 167.289 164.370 1.00 131.22 ? 344 SER A C     1 
ATOM   2747 O  O     . SER A 1 344 ? 156.088 167.450 165.367 1.00 131.22 ? 344 SER A O     1 
ATOM   2748 C  CB    . SER A 1 344 ? 157.560 164.947 163.921 1.00 131.22 ? 344 SER A CB    1 
ATOM   2749 O  OG    . SER A 1 344 ? 157.066 164.987 162.595 1.00 131.22 ? 344 SER A OG    1 
ATOM   2750 N  N     . PRO A 1 345 ? 156.570 167.954 163.234 1.00 141.26 ? 345 PRO A N     1 
ATOM   2751 C  CA    . PRO A 1 345 ? 155.434 168.888 163.147 1.00 141.26 ? 345 PRO A CA    1 
ATOM   2752 C  C     . PRO A 1 345 ? 154.082 168.241 163.397 1.00 141.26 ? 345 PRO A C     1 
ATOM   2753 O  O     . PRO A 1 345 ? 153.170 168.915 163.887 1.00 141.26 ? 345 PRO A O     1 
ATOM   2754 C  CB    . PRO A 1 345 ? 155.541 169.432 161.717 1.00 141.26 ? 345 PRO A CB    1 
ATOM   2755 C  CG    . PRO A 1 345 ? 156.980 169.282 161.368 1.00 141.26 ? 345 PRO A CG    1 
ATOM   2756 C  CD    . PRO A 1 345 ? 157.433 168.023 162.041 1.00 141.26 ? 345 PRO A CD    1 
ATOM   2757 N  N     . LYS A 1 346 ? 153.917 166.962 163.054 1.00 126.24 ? 346 LYS A N     1 
ATOM   2758 C  CA    . LYS A 1 346 ? 152.635 166.298 163.275 1.00 126.24 ? 346 LYS A CA    1 
ATOM   2759 C  C     . LYS A 1 346 ? 152.325 166.172 164.763 1.00 126.24 ? 346 LYS A C     1 
ATOM   2760 O  O     . LYS A 1 346 ? 151.185 166.398 165.189 1.00 126.24 ? 346 LYS A O     1 
ATOM   2761 C  CB    . LYS A 1 346 ? 152.641 164.929 162.599 1.00 126.24 ? 346 LYS A CB    1 
ATOM   2762 C  CG    . LYS A 1 346 ? 151.365 164.138 162.764 1.00 126.24 ? 346 LYS A CG    1 
ATOM   2763 C  CD    . LYS A 1 346 ? 151.530 162.745 162.189 1.00 126.24 ? 346 LYS A CD    1 
ATOM   2764 C  CE    . LYS A 1 346 ? 150.246 162.256 161.545 1.00 126.24 ? 346 LYS A CE    1 
ATOM   2765 N  NZ    . LYS A 1 346 ? 150.508 161.199 160.529 1.00 126.24 ? 346 LYS A NZ    1 
ATOM   2766 N  N     . VAL A 1 347 ? 153.327 165.814 165.568 1.00 109.34 ? 347 VAL A N     1 
ATOM   2767 C  CA    . VAL A 1 347 ? 153.136 165.777 167.015 1.00 109.34 ? 347 VAL A CA    1 
ATOM   2768 C  C     . VAL A 1 347 ? 152.862 167.176 167.547 1.00 109.34 ? 347 VAL A C     1 
ATOM   2769 O  O     . VAL A 1 347 ? 152.076 167.353 168.485 1.00 109.34 ? 347 VAL A O     1 
ATOM   2770 C  CB    . VAL A 1 347 ? 154.359 165.132 167.695 1.00 109.34 ? 347 VAL A CB    1 
ATOM   2771 C  CG1   . VAL A 1 347 ? 154.308 165.329 169.200 1.00 109.34 ? 347 VAL A CG1   1 
ATOM   2772 C  CG2   . VAL A 1 347 ? 154.426 163.656 167.353 1.00 109.34 ? 347 VAL A CG2   1 
ATOM   2773 N  N     . LYS A 1 348 ? 153.490 168.191 166.950 1.00 126.95 ? 348 LYS A N     1 
ATOM   2774 C  CA    . LYS A 1 348 ? 153.190 169.570 167.320 1.00 126.95 ? 348 LYS A CA    1 
ATOM   2775 C  C     . LYS A 1 348 ? 151.727 169.904 167.058 1.00 126.95 ? 348 LYS A C     1 
ATOM   2776 O  O     . LYS A 1 348 ? 151.069 170.548 167.883 1.00 126.95 ? 348 LYS A O     1 
ATOM   2777 C  CB    . LYS A 1 348 ? 154.105 170.518 166.547 1.00 126.95 ? 348 LYS A CB    1 
ATOM   2778 C  CG    . LYS A 1 348 ? 154.299 171.878 167.184 1.00 126.95 ? 348 LYS A CG    1 
ATOM   2779 C  CD    . LYS A 1 348 ? 155.441 172.627 166.513 1.00 126.95 ? 348 LYS A CD    1 
ATOM   2780 C  CE    . LYS A 1 348 ? 156.653 171.726 166.323 1.00 126.95 ? 348 LYS A CE    1 
ATOM   2781 N  NZ    . LYS A 1 348 ? 157.633 172.300 165.361 1.00 126.95 ? 348 LYS A NZ    1 
ATOM   2782 N  N     . LYS A 1 349 ? 151.202 169.473 165.910 1.00 125.90 ? 349 LYS A N     1 
ATOM   2783 C  CA    . LYS A 1 349 ? 149.800 169.719 165.590 1.00 125.90 ? 349 LYS A CA    1 
ATOM   2784 C  C     . LYS A 1 349 ? 148.879 168.983 166.554 1.00 125.90 ? 349 LYS A C     1 
ATOM   2785 O  O     . LYS A 1 349 ? 147.846 169.520 166.969 1.00 125.90 ? 349 LYS A O     1 
ATOM   2786 C  CB    . LYS A 1 349 ? 149.514 169.304 164.147 1.00 125.90 ? 349 LYS A CB    1 
ATOM   2787 C  CG    . LYS A 1 349 ? 148.052 169.399 163.743 1.00 125.90 ? 349 LYS A CG    1 
ATOM   2788 C  CD    . LYS A 1 349 ? 147.500 170.798 163.969 1.00 125.90 ? 349 LYS A CD    1 
ATOM   2789 C  CE    . LYS A 1 349 ? 148.206 171.819 163.092 1.00 125.90 ? 349 LYS A CE    1 
ATOM   2790 N  NZ    . LYS A 1 349 ? 147.802 171.700 161.665 1.00 125.90 ? 349 LYS A NZ    1 
ATOM   2791 N  N     . LEU A 1 350 ? 149.231 167.746 166.908 1.00 117.30 ? 350 LEU A N     1 
ATOM   2792 C  CA    . LEU A 1 350 ? 148.441 167.012 167.893 1.00 117.30 ? 350 LEU A CA    1 
ATOM   2793 C  C     . LEU A 1 350 ? 148.432 167.736 169.234 1.00 117.30 ? 350 LEU A C     1 
ATOM   2794 O  O     . LEU A 1 350 ? 147.386 167.841 169.890 1.00 117.30 ? 350 LEU A O     1 
ATOM   2795 C  CB    . LEU A 1 350 ? 148.983 165.593 168.057 1.00 117.30 ? 350 LEU A CB    1 
ATOM   2796 C  CG    . LEU A 1 350 ? 148.471 164.813 169.271 1.00 117.30 ? 350 LEU A CG    1 
ATOM   2797 C  CD1   . LEU A 1 350 ? 147.218 164.027 168.928 1.00 117.30 ? 350 LEU A CD1   1 
ATOM   2798 C  CD2   . LEU A 1 350 ? 149.547 163.890 169.817 1.00 117.30 ? 350 LEU A CD2   1 
ATOM   2799 N  N     . LEU A 1 351 ? 149.590 168.245 169.653 1.00 122.51 ? 351 LEU A N     1 
ATOM   2800 C  CA    . LEU A 1 351 ? 149.665 169.002 170.897 1.00 122.51 ? 351 LEU A CA    1 
ATOM   2801 C  C     . LEU A 1 351 ? 148.812 170.259 170.822 1.00 122.51 ? 351 LEU A C     1 
ATOM   2802 O  O     . LEU A 1 351 ? 148.129 170.614 171.789 1.00 122.51 ? 351 LEU A O     1 
ATOM   2803 C  CB    . LEU A 1 351 ? 151.118 169.354 171.204 1.00 122.51 ? 351 LEU A CB    1 
ATOM   2804 C  CG    . LEU A 1 351 ? 151.961 168.208 171.759 1.00 122.51 ? 351 LEU A CG    1 
ATOM   2805 C  CD1   . LEU A 1 351 ? 153.420 168.621 171.865 1.00 122.51 ? 351 LEU A CD1   1 
ATOM   2806 C  CD2   . LEU A 1 351 ? 151.424 167.768 173.110 1.00 122.51 ? 351 LEU A CD2   1 
ATOM   2807 N  N     . GLU A 1 352 ? 148.837 170.945 169.678 1.00 146.28 ? 352 GLU A N     1 
ATOM   2808 C  CA    . GLU A 1 352 ? 148.019 172.142 169.510 1.00 146.28 ? 352 GLU A CA    1 
ATOM   2809 C  C     . GLU A 1 352 ? 146.532 171.812 169.583 1.00 146.28 ? 352 GLU A C     1 
ATOM   2810 O  O     . GLU A 1 352 ? 145.749 172.559 170.183 1.00 146.28 ? 352 GLU A O     1 
ATOM   2811 C  CB    . GLU A 1 352 ? 148.359 172.816 168.181 1.00 146.28 ? 352 GLU A CB    1 
ATOM   2812 C  CG    . GLU A 1 352 ? 147.499 174.022 167.854 1.00 146.28 ? 352 GLU A CG    1 
ATOM   2813 C  CD    . GLU A 1 352 ? 147.546 175.084 168.934 1.00 146.28 ? 352 GLU A CD    1 
ATOM   2814 O  OE1   . GLU A 1 352 ? 148.628 175.291 169.524 1.00 146.28 ? 352 GLU A OE1   1 
ATOM   2815 O  OE2   . GLU A 1 352 ? 146.499 175.714 169.195 1.00 146.28 ? 352 GLU A OE2   1 
ATOM   2816 N  N     . ILE A 1 353 ? 146.123 170.698 168.973 1.00 139.87 ? 353 ILE A N     1 
ATOM   2817 C  CA    . ILE A 1 353 ? 144.723 170.283 169.025 1.00 139.87 ? 353 ILE A CA    1 
ATOM   2818 C  C     . ILE A 1 353 ? 144.311 169.976 170.460 1.00 139.87 ? 353 ILE A C     1 
ATOM   2819 O  O     . ILE A 1 353 ? 143.227 170.373 170.912 1.00 139.87 ? 353 ILE A O     1 
ATOM   2820 C  CB    . ILE A 1 353 ? 144.491 169.077 168.094 1.00 139.87 ? 353 ILE A CB    1 
ATOM   2821 C  CG1   . ILE A 1 353 ? 144.359 169.543 166.644 1.00 139.87 ? 353 ILE A CG1   1 
ATOM   2822 C  CG2   . ILE A 1 353 ? 143.261 168.293 168.518 1.00 139.87 ? 353 ILE A CG2   1 
ATOM   2823 C  CD1   . ILE A 1 353 ? 144.218 168.412 165.653 1.00 139.87 ? 353 ILE A CD1   1 
ATOM   2824 N  N     . LEU A 1 354 ? 145.166 169.265 171.198 1.00 140.80 ? 354 LEU A N     1 
ATOM   2825 C  CA    . LEU A 1 354 ? 144.863 168.982 172.597 1.00 140.80 ? 354 LEU A CA    1 
ATOM   2826 C  C     . LEU A 1 354 ? 144.786 170.267 173.412 1.00 140.80 ? 354 LEU A C     1 
ATOM   2827 O  O     . LEU A 1 354 ? 143.959 170.384 174.324 1.00 140.80 ? 354 LEU A O     1 
ATOM   2828 C  CB    . LEU A 1 354 ? 145.906 168.031 173.182 1.00 140.80 ? 354 LEU A CB    1 
ATOM   2829 C  CG    . LEU A 1 354 ? 145.424 167.115 174.310 1.00 140.80 ? 354 LEU A CG    1 
ATOM   2830 C  CD1   . LEU A 1 354 ? 146.233 165.832 174.334 1.00 140.80 ? 354 LEU A CD1   1 
ATOM   2831 C  CD2   . LEU A 1 354 ? 145.500 167.815 175.659 1.00 140.80 ? 354 LEU A CD2   1 
ATOM   2832 N  N     . LYS A 1 355 ? 145.645 171.242 173.104 1.00 170.19 ? 355 LYS A N     1 
ATOM   2833 C  CA    . LYS A 1 355 ? 145.583 172.527 173.793 1.00 170.19 ? 355 LYS A CA    1 
ATOM   2834 C  C     . LYS A 1 355 ? 144.272 173.245 173.508 1.00 170.19 ? 355 LYS A C     1 
ATOM   2835 O  O     . LYS A 1 355 ? 143.675 173.842 174.411 1.00 170.19 ? 355 LYS A O     1 
ATOM   2836 C  CB    . LYS A 1 355 ? 146.773 173.400 173.392 1.00 170.19 ? 355 LYS A CB    1 
ATOM   2837 C  CG    . LYS A 1 355 ? 148.085 172.989 174.035 1.00 170.19 ? 355 LYS A CG    1 
ATOM   2838 C  CD    . LYS A 1 355 ? 149.264 173.245 173.112 1.00 170.19 ? 355 LYS A CD    1 
ATOM   2839 C  CE    . LYS A 1 355 ? 150.453 172.384 173.502 1.00 170.19 ? 355 LYS A CE    1 
ATOM   2840 N  NZ    . LYS A 1 355 ? 150.036 170.999 173.864 1.00 170.19 ? 355 LYS A NZ    1 
ATOM   2841 N  N     . GLN A 1 356 ? 143.810 173.206 172.255 1.00 183.88 ? 356 GLN A N     1 
ATOM   2842 C  CA    . GLN A 1 356 ? 142.514 173.797 171.931 1.00 183.88 ? 356 GLN A CA    1 
ATOM   2843 C  C     . GLN A 1 356 ? 141.394 173.118 172.709 1.00 183.88 ? 356 GLN A C     1 
ATOM   2844 O  O     . GLN A 1 356 ? 140.509 173.788 173.259 1.00 183.88 ? 356 GLN A O     1 
ATOM   2845 C  CB    . GLN A 1 356 ? 142.241 173.705 170.431 1.00 183.88 ? 356 GLN A CB    1 
ATOM   2846 C  CG    . GLN A 1 356 ? 143.250 174.415 169.553 1.00 183.88 ? 356 GLN A CG    1 
ATOM   2847 C  CD    . GLN A 1 356 ? 143.396 173.748 168.201 1.00 183.88 ? 356 GLN A CD    1 
ATOM   2848 O  OE1   . GLN A 1 356 ? 142.707 172.774 167.899 1.00 183.88 ? 356 GLN A OE1   1 
ATOM   2849 N  NE2   . GLN A 1 356 ? 144.290 174.277 167.374 1.00 183.88 ? 356 GLN A NE2   1 
ATOM   2850 N  N     . TYR A 1 357 ? 141.422 171.785 172.767 1.00 213.57 ? 357 TYR A N     1 
ATOM   2851 C  CA    . TYR A 1 357 ? 140.393 171.053 173.501 1.00 213.57 ? 357 TYR A CA    1 
ATOM   2852 C  C     . TYR A 1 357 ? 140.406 171.415 174.982 1.00 213.57 ? 357 TYR A C     1 
ATOM   2853 O  O     . TYR A 1 357 ? 139.348 171.618 175.591 1.00 213.57 ? 357 TYR A O     1 
ATOM   2854 C  CB    . TYR A 1 357 ? 140.592 169.551 173.308 1.00 213.57 ? 357 TYR A CB    1 
ATOM   2855 C  CG    . TYR A 1 357 ? 139.613 168.683 174.065 1.00 213.57 ? 357 TYR A CG    1 
ATOM   2856 C  CD1   . TYR A 1 357 ? 138.347 168.425 173.559 1.00 213.57 ? 357 TYR A CD1   1 
ATOM   2857 C  CD2   . TYR A 1 357 ? 139.962 168.107 175.279 1.00 213.57 ? 357 TYR A CD2   1 
ATOM   2858 C  CE1   . TYR A 1 357 ? 137.452 167.626 174.244 1.00 213.57 ? 357 TYR A CE1   1 
ATOM   2859 C  CE2   . TYR A 1 357 ? 139.075 167.307 175.970 1.00 213.57 ? 357 TYR A CE2   1 
ATOM   2860 C  CZ    . TYR A 1 357 ? 137.822 167.071 175.451 1.00 213.57 ? 357 TYR A CZ    1 
ATOM   2861 O  OH    . TYR A 1 357 ? 136.936 166.275 176.140 1.00 213.57 ? 357 TYR A OH    1 
ATOM   2862 N  N     . PHE A 1 358 ? 141.599 171.506 175.578 1.00 208.41 ? 358 PHE A N     1 
ATOM   2863 C  CA    . PHE A 1 358 ? 141.689 171.851 176.992 1.00 208.41 ? 358 PHE A CA    1 
ATOM   2864 C  C     . PHE A 1 358 ? 141.226 173.278 177.249 1.00 208.41 ? 358 PHE A C     1 
ATOM   2865 O  O     . PHE A 1 358 ? 140.573 173.552 178.261 1.00 208.41 ? 358 PHE A O     1 
ATOM   2866 C  CB    . PHE A 1 358 ? 143.117 171.670 177.499 1.00 208.41 ? 358 PHE A CB    1 
ATOM   2867 C  CG    . PHE A 1 358 ? 143.320 172.162 178.901 1.00 208.41 ? 358 PHE A CG    1 
ATOM   2868 C  CD1   . PHE A 1 358 ? 142.585 171.630 179.947 1.00 208.41 ? 358 PHE A CD1   1 
ATOM   2869 C  CD2   . PHE A 1 358 ? 144.227 173.172 179.171 1.00 208.41 ? 358 PHE A CD2   1 
ATOM   2870 C  CE1   . PHE A 1 358 ? 142.763 172.083 181.238 1.00 208.41 ? 358 PHE A CE1   1 
ATOM   2871 C  CE2   . PHE A 1 358 ? 144.409 173.631 180.462 1.00 208.41 ? 358 PHE A CE2   1 
ATOM   2872 C  CZ    . PHE A 1 358 ? 143.676 173.085 181.497 1.00 208.41 ? 358 PHE A CZ    1 
ATOM   2873 N  N     . SER A 1 359 ? 141.575 174.209 176.359 1.00 221.26 ? 359 SER A N     1 
ATOM   2874 C  CA    . SER A 1 359 ? 141.120 175.583 176.527 1.00 221.26 ? 359 SER A CA    1 
ATOM   2875 C  C     . SER A 1 359 ? 139.610 175.686 176.380 1.00 221.26 ? 359 SER A C     1 
ATOM   2876 O  O     . SER A 1 359 ? 138.981 176.548 177.006 1.00 221.26 ? 359 SER A O     1 
ATOM   2877 C  CB    . SER A 1 359 ? 141.819 176.500 175.525 1.00 221.26 ? 359 SER A CB    1 
ATOM   2878 O  OG    . SER A 1 359 ? 142.067 175.827 174.306 1.00 221.26 ? 359 SER A OG    1 
ATOM   2879 N  N     . ASN A 1 360 ? 139.011 174.827 175.553 1.00 252.32 ? 360 ASN A N     1 
ATOM   2880 C  CA    . ASN A 1 360 ? 137.556 174.810 175.450 1.00 252.32 ? 360 ASN A CA    1 
ATOM   2881 C  C     . ASN A 1 360 ? 136.915 174.227 176.705 1.00 252.32 ? 360 ASN A C     1 
ATOM   2882 O  O     . ASN A 1 360 ? 135.896 174.741 177.183 1.00 252.32 ? 360 ASN A O     1 
ATOM   2883 C  CB    . ASN A 1 360 ? 137.124 174.020 174.215 1.00 252.32 ? 360 ASN A CB    1 
ATOM   2884 C  CG    . ASN A 1 360 ? 135.623 174.041 174.008 1.00 252.32 ? 360 ASN A CG    1 
ATOM   2885 O  OD1   . ASN A 1 360 ? 135.014 175.106 173.904 1.00 252.32 ? 360 ASN A OD1   1 
ATOM   2886 N  ND2   . ASN A 1 360 ? 135.017 172.861 173.951 1.00 252.32 ? 360 ASN A ND2   1 
ATOM   2887 N  N     . ASN A 1 361 ? 137.494 173.161 177.254 1.00 275.34 ? 361 ASN A N     1 
ATOM   2888 C  CA    . ASN A 1 361 ? 136.867 172.430 178.351 1.00 275.34 ? 361 ASN A CA    1 
ATOM   2889 C  C     . ASN A 1 361 ? 137.279 172.911 179.738 1.00 275.34 ? 361 ASN A C     1 
ATOM   2890 O  O     . ASN A 1 361 ? 136.766 172.383 180.730 1.00 275.34 ? 361 ASN A O     1 
ATOM   2891 C  CB    . ASN A 1 361 ? 137.167 170.934 178.224 1.00 275.34 ? 361 ASN A CB    1 
ATOM   2892 C  CG    . ASN A 1 361 ? 136.178 170.218 177.328 1.00 275.34 ? 361 ASN A CG    1 
ATOM   2893 O  OD1   . ASN A 1 361 ? 135.105 169.808 177.772 1.00 275.34 ? 361 ASN A OD1   1 
ATOM   2894 N  ND2   . ASN A 1 361 ? 136.529 170.073 176.057 1.00 275.34 ? 361 ASN A ND2   1 
ATOM   2895 N  N     . ASN A 1 362 ? 138.193 173.880 179.843 1.00 267.84 ? 362 ASN A N     1 
ATOM   2896 C  CA    . ASN A 1 362 ? 138.553 174.390 181.164 1.00 267.84 ? 362 ASN A CA    1 
ATOM   2897 C  C     . ASN A 1 362 ? 137.360 175.046 181.846 1.00 267.84 ? 362 ASN A C     1 
ATOM   2898 O  O     . ASN A 1 362 ? 137.147 174.866 183.052 1.00 267.84 ? 362 ASN A O     1 
ATOM   2899 C  CB    . ASN A 1 362 ? 139.724 175.370 181.057 1.00 267.84 ? 362 ASN A CB    1 
ATOM   2900 C  CG    . ASN A 1 362 ? 139.493 176.453 180.020 1.00 267.84 ? 362 ASN A CG    1 
ATOM   2901 O  OD1   . ASN A 1 362 ? 138.357 176.835 179.740 1.00 267.84 ? 362 ASN A OD1   1 
ATOM   2902 N  ND2   . ASN A 1 362 ? 140.579 176.962 179.451 1.00 267.84 ? 362 ASN A ND2   1 
ATOM   2903 N  N     . ASN A 1 363 ? 136.571 175.815 181.092 1.00 283.08 ? 363 ASN A N     1 
ATOM   2904 C  CA    . ASN A 1 363 ? 135.353 176.392 181.648 1.00 283.08 ? 363 ASN A CA    1 
ATOM   2905 C  C     . ASN A 1 363 ? 134.317 175.314 181.937 1.00 283.08 ? 363 ASN A C     1 
ATOM   2906 O  O     . ASN A 1 363 ? 133.556 175.419 182.906 1.00 283.08 ? 363 ASN A O     1 
ATOM   2907 C  CB    . ASN A 1 363 ? 134.786 177.441 180.692 1.00 283.08 ? 363 ASN A CB    1 
ATOM   2908 C  CG    . ASN A 1 363 ? 135.692 178.646 180.545 1.00 283.08 ? 363 ASN A CG    1 
ATOM   2909 O  OD1   . ASN A 1 363 ? 136.744 178.729 181.179 1.00 283.08 ? 363 ASN A OD1   1 
ATOM   2910 N  ND2   . ASN A 1 363 ? 135.288 179.591 179.703 1.00 283.08 ? 363 ASN A ND2   1 
ATOM   2911 N  N     . SER A 1 364 ? 134.268 174.277 181.104 1.00 301.92 ? 364 SER A N     1 
ATOM   2912 C  CA    . SER A 1 364 ? 133.313 173.196 181.302 1.00 301.92 ? 364 SER A CA    1 
ATOM   2913 C  C     . SER A 1 364 ? 133.645 172.415 182.568 1.00 301.92 ? 364 SER A C     1 
ATOM   2914 O  O     . SER A 1 364 ? 134.808 172.085 182.821 1.00 301.92 ? 364 SER A O     1 
ATOM   2915 C  CB    . SER A 1 364 ? 133.313 172.264 180.091 1.00 301.92 ? 364 SER A CB    1 
ATOM   2916 O  OG    . SER A 1 364 ? 132.461 171.151 180.303 1.00 301.92 ? 364 SER A OG    1 
ATOM   2917 N  N     . SER A 1 365 ? 132.617 172.121 183.366 1.00 311.44 ? 365 SER A N     1 
ATOM   2918 C  CA    . SER A 1 365 ? 132.814 171.321 184.568 1.00 311.44 ? 365 SER A CA    1 
ATOM   2919 C  C     . SER A 1 365 ? 133.013 169.846 184.244 1.00 311.44 ? 365 SER A C     1 
ATOM   2920 O  O     . SER A 1 365 ? 133.571 169.107 185.064 1.00 311.44 ? 365 SER A O     1 
ATOM   2921 C  CB    . SER A 1 365 ? 131.625 171.494 185.515 1.00 311.44 ? 365 SER A CB    1 
ATOM   2922 O  OG    . SER A 1 365 ? 130.438 170.976 184.941 1.00 311.44 ? 365 SER A OG    1 
ATOM   2923 N  N     . LYS A 1 366 ? 132.564 169.404 183.071 1.00 287.83 ? 366 LYS A N     1 
ATOM   2924 C  CA    . LYS A 1 366 ? 132.743 168.014 182.674 1.00 287.83 ? 366 LYS A CA    1 
ATOM   2925 C  C     . LYS A 1 366 ? 134.223 167.690 182.527 1.00 287.83 ? 366 LYS A C     1 
ATOM   2926 O  O     . LYS A 1 366 ? 134.994 168.463 181.952 1.00 287.83 ? 366 LYS A O     1 
ATOM   2927 C  CB    . LYS A 1 366 ? 132.009 167.741 181.360 1.00 287.83 ? 366 LYS A CB    1 
ATOM   2928 C  CG    . LYS A 1 366 ? 130.492 167.773 181.476 1.00 287.83 ? 366 LYS A CG    1 
ATOM   2929 C  CD    . LYS A 1 366 ? 129.830 167.746 180.105 1.00 287.83 ? 366 LYS A CD    1 
ATOM   2930 C  CE    . LYS A 1 366 ? 130.129 166.450 179.367 1.00 287.83 ? 366 LYS A CE    1 
ATOM   2931 N  NZ    . LYS A 1 366 ? 129.408 166.373 178.065 1.00 287.83 ? 366 LYS A NZ    1 
ATOM   2932 N  N     . GLU A 1 367 ? 134.620 166.533 183.052 1.00 251.01 ? 367 GLU A N     1 
ATOM   2933 C  CA    . GLU A 1 367 ? 136.014 166.127 183.011 1.00 251.01 ? 367 GLU A CA    1 
ATOM   2934 C  C     . GLU A 1 367 ? 136.377 165.623 181.616 1.00 251.01 ? 367 GLU A C     1 
ATOM   2935 O  O     . GLU A 1 367 ? 135.534 165.508 180.723 1.00 251.01 ? 367 GLU A O     1 
ATOM   2936 C  CB    . GLU A 1 367 ? 136.289 165.070 184.078 1.00 251.01 ? 367 GLU A CB    1 
ATOM   2937 C  CG    . GLU A 1 367 ? 136.190 165.598 185.502 1.00 251.01 ? 367 GLU A CG    1 
ATOM   2938 C  CD    . GLU A 1 367 ? 136.969 166.885 185.706 1.00 251.01 ? 367 GLU A CD    1 
ATOM   2939 O  OE1   . GLU A 1 367 ? 138.132 166.959 185.257 1.00 251.01 ? 367 GLU A OE1   1 
ATOM   2940 O  OE2   . GLU A 1 367 ? 136.414 167.825 186.314 1.00 251.01 ? 367 GLU A OE2   1 
ATOM   2941 N  N     . LEU A 1 368 ? 137.657 165.316 181.427 1.00 215.38 ? 368 LEU A N     1 
ATOM   2942 C  CA    . LEU A 1 368 ? 138.179 164.966 180.115 1.00 215.38 ? 368 LEU A CA    1 
ATOM   2943 C  C     . LEU A 1 368 ? 138.169 163.454 179.919 1.00 215.38 ? 368 LEU A C     1 
ATOM   2944 O  O     . LEU A 1 368 ? 138.468 162.694 180.843 1.00 215.38 ? 368 LEU A O     1 
ATOM   2945 C  CB    . LEU A 1 368 ? 139.602 165.502 179.942 1.00 215.38 ? 368 LEU A CB    1 
ATOM   2946 C  CG    . LEU A 1 368 ? 139.808 167.017 180.025 1.00 215.38 ? 368 LEU A CG    1 
ATOM   2947 C  CD1   . LEU A 1 368 ? 138.639 167.765 179.400 1.00 215.38 ? 368 LEU A CD1   1 
ATOM   2948 C  CD2   . LEU A 1 368 ? 140.050 167.477 181.460 1.00 215.38 ? 368 LEU A CD2   1 
ATOM   2949 N  N     . CYS A 1 369 ? 137.816 163.030 178.707 1.00 188.53 ? 369 CYS A N     1 
ATOM   2950 C  CA    . CYS A 1 369 ? 137.872 161.622 178.322 1.00 188.53 ? 369 CYS A CA    1 
ATOM   2951 C  C     . CYS A 1 369 ? 138.200 161.549 176.840 1.00 188.53 ? 369 CYS A C     1 
ATOM   2952 O  O     . CYS A 1 369 ? 137.431 162.049 176.014 1.00 188.53 ? 369 CYS A O     1 
ATOM   2953 C  CB    . CYS A 1 369 ? 136.550 160.908 178.617 1.00 188.53 ? 369 CYS A CB    1 
ATOM   2954 S  SG    . CYS A 1 369 ? 136.163 160.698 180.371 1.00 188.53 ? 369 CYS A SG    1 
ATOM   2955 N  N     . GLY A 1 370 ? 139.326 160.935 176.505 1.00 162.06 ? 370 GLY A N     1 
ATOM   2956 C  CA    . GLY A 1 370 ? 139.761 160.863 175.122 1.00 162.06 ? 370 GLY A CA    1 
ATOM   2957 C  C     . GLY A 1 370 ? 140.437 159.545 174.814 1.00 162.06 ? 370 GLY A C     1 
ATOM   2958 O  O     . GLY A 1 370 ? 141.057 158.920 175.678 1.00 162.06 ? 370 GLY A O     1 
ATOM   2959 N  N     . ILE A 1 371 ? 140.325 159.139 173.549 1.00 178.15 ? 371 ILE A N     1 
ATOM   2960 C  CA    . ILE A 1 371 ? 140.898 157.899 173.038 1.00 178.15 ? 371 ILE A CA    1 
ATOM   2961 C  C     . ILE A 1 371 ? 141.823 158.244 171.880 1.00 178.15 ? 371 ILE A C     1 
ATOM   2962 O  O     . ILE A 1 371 ? 141.515 159.130 171.075 1.00 178.15 ? 371 ILE A O     1 
ATOM   2963 C  CB    . ILE A 1 371 ? 139.809 156.908 172.565 1.00 178.15 ? 371 ILE A CB    1 
ATOM   2964 C  CG1   . ILE A 1 371 ? 138.742 156.664 173.635 1.00 178.15 ? 371 ILE A CG1   1 
ATOM   2965 C  CG2   . ILE A 1 371 ? 140.433 155.581 172.181 1.00 178.15 ? 371 ILE A CG2   1 
ATOM   2966 C  CD1   . ILE A 1 371 ? 139.283 156.406 175.014 1.00 178.15 ? 371 ILE A CD1   1 
ATOM   2967 N  N     . ILE A 1 372 ? 142.954 157.545 171.789 1.00 159.88 ? 372 ILE A N     1 
ATOM   2968 C  CA    . ILE A 1 372 ? 143.893 157.696 170.684 1.00 159.88 ? 372 ILE A CA    1 
ATOM   2969 C  C     . ILE A 1 372 ? 144.149 156.324 170.076 1.00 159.88 ? 372 ILE A C     1 
ATOM   2970 O  O     . ILE A 1 372 ? 144.382 155.351 170.803 1.00 159.88 ? 372 ILE A O     1 
ATOM   2971 C  CB    . ILE A 1 372 ? 145.211 158.349 171.136 1.00 159.88 ? 372 ILE A CB    1 
ATOM   2972 C  CG1   . ILE A 1 372 ? 144.935 159.684 171.827 1.00 159.88 ? 372 ILE A CG1   1 
ATOM   2973 C  CG2   . ILE A 1 372 ? 146.138 158.553 169.950 1.00 159.88 ? 372 ILE A CG2   1 
ATOM   2974 C  CD1   . ILE A 1 372 ? 146.176 160.354 172.365 1.00 159.88 ? 372 ILE A CD1   1 
ATOM   2975 N  N     . PHE A 1 373 ? 144.113 156.251 168.747 1.00 165.64 ? 373 PHE A N     1 
ATOM   2976 C  CA    . PHE A 1 373 ? 144.299 155.008 168.010 1.00 165.64 ? 373 PHE A CA    1 
ATOM   2977 C  C     . PHE A 1 373 ? 145.593 155.062 167.209 1.00 165.64 ? 373 PHE A C     1 
ATOM   2978 O  O     . PHE A 1 373 ? 145.799 155.988 166.418 1.00 165.64 ? 373 PHE A O     1 
ATOM   2979 C  CB    . PHE A 1 373 ? 143.118 154.750 167.073 1.00 165.64 ? 373 PHE A CB    1 
ATOM   2980 C  CG    . PHE A 1 373 ? 141.832 154.449 167.784 1.00 165.64 ? 373 PHE A CG    1 
ATOM   2981 C  CD1   . PHE A 1 373 ? 141.819 153.635 168.901 1.00 165.64 ? 373 PHE A CD1   1 
ATOM   2982 C  CD2   . PHE A 1 373 ? 140.637 154.986 167.338 1.00 165.64 ? 373 PHE A CD2   1 
ATOM   2983 C  CE1   . PHE A 1 373 ? 140.637 153.353 169.556 1.00 165.64 ? 373 PHE A CE1   1 
ATOM   2984 C  CE2   . PHE A 1 373 ? 139.452 154.712 167.992 1.00 165.64 ? 373 PHE A CE2   1 
ATOM   2985 C  CZ    . PHE A 1 373 ? 139.452 153.895 169.103 1.00 165.64 ? 373 PHE A CZ    1 
ATOM   2986 N  N     . VAL A 1 374 ? 146.458 154.069 167.414 1.00 181.65 ? 374 VAL A N     1 
ATOM   2987 C  CA    . VAL A 1 374 ? 147.707 153.935 166.674 1.00 181.65 ? 374 VAL A CA    1 
ATOM   2988 C  C     . VAL A 1 374 ? 147.809 152.502 166.166 1.00 181.65 ? 374 VAL A C     1 
ATOM   2989 O  O     . VAL A 1 374 ? 147.244 151.575 166.754 1.00 181.65 ? 374 VAL A O     1 
ATOM   2990 C  CB    . VAL A 1 374 ? 148.937 154.301 167.539 1.00 181.65 ? 374 VAL A CB    1 
ATOM   2991 C  CG1   . VAL A 1 374 ? 150.179 154.456 166.674 1.00 181.65 ? 374 VAL A CG1   1 
ATOM   2992 C  CG2   . VAL A 1 374 ? 148.680 155.575 168.328 1.00 181.65 ? 374 VAL A CG2   1 
ATOM   2993 N  N     . GLU A 1 375 ? 148.535 152.324 165.060 1.00 185.67 ? 375 GLU A N     1 
ATOM   2994 C  CA    . GLU A 1 375 ? 148.596 151.017 164.412 1.00 185.67 ? 375 GLU A CA    1 
ATOM   2995 C  C     . GLU A 1 375 ? 149.553 150.070 165.129 1.00 185.67 ? 375 GLU A C     1 
ATOM   2996 O  O     . GLU A 1 375 ? 149.225 148.902 165.361 1.00 185.67 ? 375 GLU A O     1 
ATOM   2997 C  CB    . GLU A 1 375 ? 149.004 151.177 162.947 1.00 185.67 ? 375 GLU A CB    1 
ATOM   2998 C  CG    . GLU A 1 375 ? 147.902 150.840 161.958 1.00 185.67 ? 375 GLU A CG    1 
ATOM   2999 C  CD    . GLU A 1 375 ? 148.193 151.359 160.565 1.00 185.67 ? 375 GLU A CD    1 
ATOM   3000 O  OE1   . GLU A 1 375 ? 149.355 151.731 160.300 1.00 185.67 ? 375 GLU A OE1   1 
ATOM   3001 O  OE2   . GLU A 1 375 ? 147.262 151.393 159.734 1.00 185.67 ? 375 GLU A OE2   1 
ATOM   3002 N  N     . ARG A 1 376 ? 150.741 150.551 165.486 1.00 177.48 ? 376 ARG A N     1 
ATOM   3003 C  CA    . ARG A 1 376 ? 151.819 149.691 165.959 1.00 177.48 ? 376 ARG A CA    1 
ATOM   3004 C  C     . ARG A 1 376 ? 151.928 149.734 167.478 1.00 177.48 ? 376 ARG A C     1 
ATOM   3005 O  O     . ARG A 1 376 ? 151.782 150.794 168.093 1.00 177.48 ? 376 ARG A O     1 
ATOM   3006 C  CB    . ARG A 1 376 ? 153.148 150.106 165.326 1.00 177.48 ? 376 ARG A CB    1 
ATOM   3007 C  CG    . ARG A 1 376 ? 154.299 149.155 165.599 1.00 177.48 ? 376 ARG A CG    1 
ATOM   3008 C  CD    . ARG A 1 376 ? 155.453 149.404 164.639 1.00 177.48 ? 376 ARG A CD    1 
ATOM   3009 N  NE    . ARG A 1 376 ? 155.140 148.968 163.284 1.00 177.48 ? 376 ARG A NE    1 
ATOM   3010 C  CZ    . ARG A 1 376 ? 154.758 149.775 162.303 1.00 177.48 ? 376 ARG A CZ    1 
ATOM   3011 N  NH1   . ARG A 1 376 ? 154.627 151.078 162.492 1.00 177.48 ? 376 ARG A NH1   1 
ATOM   3012 N  NH2   . ARG A 1 376 ? 154.499 149.263 161.104 1.00 177.48 ? 376 ARG A NH2   1 
ATOM   3013 N  N     . ARG A 1 377 ? 152.186 148.567 168.077 1.00 172.78 ? 377 ARG A N     1 
ATOM   3014 C  CA    . ARG A 1 377 ? 152.301 148.482 169.531 1.00 172.78 ? 377 ARG A CA    1 
ATOM   3015 C  C     . ARG A 1 377 ? 153.472 149.309 170.049 1.00 172.78 ? 377 ARG A C     1 
ATOM   3016 O  O     . ARG A 1 377 ? 153.333 150.054 171.026 1.00 172.78 ? 377 ARG A O     1 
ATOM   3017 C  CB    . ARG A 1 377 ? 152.454 147.023 169.962 1.00 172.78 ? 377 ARG A CB    1 
ATOM   3018 C  CG    . ARG A 1 377 ? 151.334 146.106 169.500 1.00 172.78 ? 377 ARG A CG    1 
ATOM   3019 C  CD    . ARG A 1 377 ? 151.748 144.642 169.583 1.00 172.78 ? 377 ARG A CD    1 
ATOM   3020 N  NE    . ARG A 1 377 ? 152.139 144.251 170.932 1.00 172.78 ? 377 ARG A NE    1 
ATOM   3021 C  CZ    . ARG A 1 377 ? 152.679 143.081 171.244 1.00 172.78 ? 377 ARG A CZ    1 
ATOM   3022 N  NH1   . ARG A 1 377 ? 152.911 142.161 170.322 1.00 172.78 ? 377 ARG A NH1   1 
ATOM   3023 N  NH2   . ARG A 1 377 ? 152.993 142.828 172.510 1.00 172.78 ? 377 ARG A NH2   1 
ATOM   3024 N  N     . TYR A 1 378 ? 154.638 149.186 169.409 1.00 174.56 ? 378 TYR A N     1 
ATOM   3025 C  CA    . TYR A 1 378 ? 155.808 149.922 169.873 1.00 174.56 ? 378 TYR A CA    1 
ATOM   3026 C  C     . TYR A 1 378 ? 155.608 151.424 169.728 1.00 174.56 ? 378 TYR A C     1 
ATOM   3027 O  O     . TYR A 1 378 ? 156.059 152.201 170.577 1.00 174.56 ? 378 TYR A O     1 
ATOM   3028 C  CB    . TYR A 1 378 ? 157.056 149.465 169.119 1.00 174.56 ? 378 TYR A CB    1 
ATOM   3029 C  CG    . TYR A 1 378 ? 158.208 149.106 170.029 1.00 174.56 ? 378 TYR A CG    1 
ATOM   3030 C  CD1   . TYR A 1 378 ? 158.197 147.927 170.760 1.00 174.56 ? 378 TYR A CD1   1 
ATOM   3031 C  CD2   . TYR A 1 378 ? 159.301 149.951 170.163 1.00 174.56 ? 378 TYR A CD2   1 
ATOM   3032 C  CE1   . TYR A 1 378 ? 159.246 147.595 171.596 1.00 174.56 ? 378 TYR A CE1   1 
ATOM   3033 C  CE2   . TYR A 1 378 ? 160.355 149.628 170.997 1.00 174.56 ? 378 TYR A CE2   1 
ATOM   3034 C  CZ    . TYR A 1 378 ? 160.321 148.449 171.712 1.00 174.56 ? 378 TYR A CZ    1 
ATOM   3035 O  OH    . TYR A 1 378 ? 161.368 148.123 172.543 1.00 174.56 ? 378 TYR A OH    1 
ATOM   3036 N  N     . THR A 1 379 ? 154.939 151.850 168.652 1.00 157.55 ? 379 THR A N     1 
ATOM   3037 C  CA    . THR A 1 379 ? 154.628 153.264 168.489 1.00 157.55 ? 379 THR A CA    1 
ATOM   3038 C  C     . THR A 1 379 ? 153.751 153.763 169.630 1.00 157.55 ? 379 THR A C     1 
ATOM   3039 O  O     . THR A 1 379 ? 153.988 154.845 170.179 1.00 157.55 ? 379 THR A O     1 
ATOM   3040 C  CB    . THR A 1 379 ? 153.941 153.504 167.145 1.00 157.55 ? 379 THR A CB    1 
ATOM   3041 O  OG1   . THR A 1 379 ? 154.698 152.880 166.102 1.00 157.55 ? 379 THR A OG1   1 
ATOM   3042 C  CG2   . THR A 1 379 ? 153.833 154.994 166.863 1.00 157.55 ? 379 THR A CG2   1 
ATOM   3043 N  N     . ALA A 1 380 ? 152.743 152.977 170.010 1.00 167.19 ? 380 ALA A N     1 
ATOM   3044 C  CA    . ALA A 1 380 ? 151.897 153.357 171.135 1.00 167.19 ? 380 ALA A CA    1 
ATOM   3045 C  C     . ALA A 1 380 ? 152.701 153.426 172.425 1.00 167.19 ? 380 ALA A C     1 
ATOM   3046 O  O     . ALA A 1 380 ? 152.487 154.319 173.251 1.00 167.19 ? 380 ALA A O     1 
ATOM   3047 C  CB    . ALA A 1 380 ? 150.737 152.373 171.276 1.00 167.19 ? 380 ALA A CB    1 
ATOM   3048 N  N     . TYR A 1 381 ? 153.639 152.494 172.612 1.00 167.82 ? 381 TYR A N     1 
ATOM   3049 C  CA    . TYR A 1 381 ? 154.448 152.491 173.828 1.00 167.82 ? 381 TYR A CA    1 
ATOM   3050 C  C     . TYR A 1 381 ? 155.319 153.741 173.917 1.00 167.82 ? 381 TYR A C     1 
ATOM   3051 O  O     . TYR A 1 381 ? 155.374 154.406 174.963 1.00 167.82 ? 381 TYR A O     1 
ATOM   3052 C  CB    . TYR A 1 381 ? 155.304 151.225 173.873 1.00 167.82 ? 381 TYR A CB    1 
ATOM   3053 C  CG    . TYR A 1 381 ? 156.167 151.106 175.106 1.00 167.82 ? 381 TYR A CG    1 
ATOM   3054 C  CD1   . TYR A 1 381 ? 155.601 151.083 176.372 1.00 167.82 ? 381 TYR A CD1   1 
ATOM   3055 C  CD2   . TYR A 1 381 ? 157.546 151.008 175.003 1.00 167.82 ? 381 TYR A CD2   1 
ATOM   3056 C  CE1   . TYR A 1 381 ? 156.384 150.971 177.502 1.00 167.82 ? 381 TYR A CE1   1 
ATOM   3057 C  CE2   . TYR A 1 381 ? 158.340 150.895 176.127 1.00 167.82 ? 381 TYR A CE2   1 
ATOM   3058 C  CZ    . TYR A 1 381 ? 157.754 150.878 177.374 1.00 167.82 ? 381 TYR A CZ    1 
ATOM   3059 O  OH    . TYR A 1 381 ? 158.540 150.766 178.498 1.00 167.82 ? 381 TYR A OH    1 
ATOM   3060 N  N     . VAL A 1 382 ? 156.005 154.085 172.824 1.00 151.31 ? 382 VAL A N     1 
ATOM   3061 C  CA    . VAL A 1 382 ? 156.881 155.252 172.865 1.00 151.31 ? 382 VAL A CA    1 
ATOM   3062 C  C     . VAL A 1 382 ? 156.053 156.527 172.990 1.00 151.31 ? 382 VAL A C     1 
ATOM   3063 O  O     . VAL A 1 382 ? 156.463 157.483 173.657 1.00 151.31 ? 382 VAL A O     1 
ATOM   3064 C  CB    . VAL A 1 382 ? 157.821 155.295 171.642 1.00 151.31 ? 382 VAL A CB    1 
ATOM   3065 C  CG1   . VAL A 1 382 ? 157.069 155.053 170.358 1.00 151.31 ? 382 VAL A CG1   1 
ATOM   3066 C  CG2   . VAL A 1 382 ? 158.585 156.606 171.588 1.00 151.31 ? 382 VAL A CG2   1 
ATOM   3067 N  N     . LEU A 1 383 ? 154.870 156.560 172.368 1.00 136.47 ? 383 LEU A N     1 
ATOM   3068 C  CA    . LEU A 1 383 ? 153.986 157.708 172.537 1.00 136.47 ? 383 LEU A CA    1 
ATOM   3069 C  C     . LEU A 1 383 ? 153.545 157.857 173.988 1.00 136.47 ? 383 LEU A C     1 
ATOM   3070 O  O     . LEU A 1 383 ? 153.510 158.970 174.523 1.00 136.47 ? 383 LEU A O     1 
ATOM   3071 C  CB    . LEU A 1 383 ? 152.772 157.571 171.620 1.00 136.47 ? 383 LEU A CB    1 
ATOM   3072 C  CG    . LEU A 1 383 ? 152.053 158.863 171.230 1.00 136.47 ? 383 LEU A CG    1 
ATOM   3073 C  CD1   . LEU A 1 383 ? 153.053 159.921 170.797 1.00 136.47 ? 383 LEU A CD1   1 
ATOM   3074 C  CD2   . LEU A 1 383 ? 151.039 158.601 170.132 1.00 136.47 ? 383 LEU A CD2   1 
ATOM   3075 N  N     . TYR A 1 384 ? 153.195 156.746 174.637 1.00 143.77 ? 384 TYR A N     1 
ATOM   3076 C  CA    . TYR A 1 384 ? 152.820 156.807 176.044 1.00 143.77 ? 384 TYR A CA    1 
ATOM   3077 C  C     . TYR A 1 384 ? 153.968 157.348 176.881 1.00 143.77 ? 384 TYR A C     1 
ATOM   3078 O  O     . TYR A 1 384 ? 153.764 158.201 177.754 1.00 143.77 ? 384 TYR A O     1 
ATOM   3079 C  CB    . TYR A 1 384 ? 152.395 155.421 176.532 1.00 143.77 ? 384 TYR A CB    1 
ATOM   3080 C  CG    . TYR A 1 384 ? 152.697 155.150 177.988 1.00 143.77 ? 384 TYR A CG    1 
ATOM   3081 C  CD1   . TYR A 1 384 ? 152.010 155.812 178.997 1.00 143.77 ? 384 TYR A CD1   1 
ATOM   3082 C  CD2   . TYR A 1 384 ? 153.668 154.229 178.354 1.00 143.77 ? 384 TYR A CD2   1 
ATOM   3083 C  CE1   . TYR A 1 384 ? 152.283 155.565 180.328 1.00 143.77 ? 384 TYR A CE1   1 
ATOM   3084 C  CE2   . TYR A 1 384 ? 153.948 153.976 179.682 1.00 143.77 ? 384 TYR A CE2   1 
ATOM   3085 C  CZ    . TYR A 1 384 ? 153.252 154.646 180.664 1.00 143.77 ? 384 TYR A CZ    1 
ATOM   3086 O  OH    . TYR A 1 384 ? 153.529 154.397 181.988 1.00 143.77 ? 384 TYR A OH    1 
ATOM   3087 N  N     . LYS A 1 385 ? 155.188 156.884 176.605 1.00 151.30 ? 385 LYS A N     1 
ATOM   3088 C  CA    . LYS A 1 385 ? 156.352 157.415 177.308 1.00 151.30 ? 385 LYS A CA    1 
ATOM   3089 C  C     . LYS A 1 385 ? 156.513 158.912 177.060 1.00 151.30 ? 385 LYS A C     1 
ATOM   3090 O  O     . LYS A 1 385 ? 156.837 159.672 177.981 1.00 151.30 ? 385 LYS A O     1 
ATOM   3091 C  CB    . LYS A 1 385 ? 157.611 156.661 176.879 1.00 151.30 ? 385 LYS A CB    1 
ATOM   3092 C  CG    . LYS A 1 385 ? 157.874 155.389 177.667 1.00 151.30 ? 385 LYS A CG    1 
ATOM   3093 C  CD    . LYS A 1 385 ? 157.578 155.582 179.144 1.00 151.30 ? 385 LYS A CD    1 
ATOM   3094 C  CE    . LYS A 1 385 ? 158.457 154.688 180.003 1.00 151.30 ? 385 LYS A CE    1 
ATOM   3095 N  NZ    . LYS A 1 385 ? 158.486 155.138 181.422 1.00 151.30 ? 385 LYS A NZ    1 
ATOM   3096 N  N     . LEU A 1 386 ? 156.282 159.354 175.821 1.00 152.43 ? 386 LEU A N     1 
ATOM   3097 C  CA    . LEU A 1 386 ? 156.472 160.760 175.480 1.00 152.43 ? 386 LEU A CA    1 
ATOM   3098 C  C     . LEU A 1 386 ? 155.486 161.652 176.221 1.00 152.43 ? 386 LEU A C     1 
ATOM   3099 O  O     . LEU A 1 386 ? 155.875 162.665 176.810 1.00 152.43 ? 386 LEU A O     1 
ATOM   3100 C  CB    . LEU A 1 386 ? 156.340 160.960 173.971 1.00 152.43 ? 386 LEU A CB    1 
ATOM   3101 C  CG    . LEU A 1 386 ? 156.166 162.419 173.540 1.00 152.43 ? 386 LEU A CG    1 
ATOM   3102 C  CD1   . LEU A 1 386 ? 157.420 163.225 173.842 1.00 152.43 ? 386 LEU A CD1   1 
ATOM   3103 C  CD2   . LEU A 1 386 ? 155.806 162.510 172.067 1.00 152.43 ? 386 LEU A CD2   1 
ATOM   3104 N  N     . LEU A 1 387 ? 154.195 161.309 176.182 1.00 149.65 ? 387 LEU A N     1 
ATOM   3105 C  CA    . LEU A 1 387 ? 153.222 162.118 176.919 1.00 149.65 ? 387 LEU A CA    1 
ATOM   3106 C  C     . LEU A 1 387 ? 153.422 162.023 178.426 1.00 149.65 ? 387 LEU A C     1 
ATOM   3107 O  O     . LEU A 1 387 ? 153.175 162.999 179.144 1.00 149.65 ? 387 LEU A O     1 
ATOM   3108 C  CB    . LEU A 1 387 ? 151.778 161.771 176.536 1.00 149.65 ? 387 LEU A CB    1 
ATOM   3109 C  CG    . LEU A 1 387 ? 151.206 162.050 175.136 1.00 149.65 ? 387 LEU A CG    1 
ATOM   3110 C  CD1   . LEU A 1 387 ? 151.314 163.542 174.849 1.00 149.65 ? 387 LEU A CD1   1 
ATOM   3111 C  CD2   . LEU A 1 387 ? 151.817 161.277 174.000 1.00 149.65 ? 387 LEU A CD2   1 
ATOM   3112 N  N     . ASN A 1 388 ? 153.884 160.877 178.936 1.00 170.25 ? 388 ASN A N     1 
ATOM   3113 C  CA    . ASN A 1 388 ? 154.218 160.815 180.354 1.00 170.25 ? 388 ASN A CA    1 
ATOM   3114 C  C     . ASN A 1 388 ? 155.335 161.794 180.691 1.00 170.25 ? 388 ASN A C     1 
ATOM   3115 O  O     . ASN A 1 388 ? 155.270 162.505 181.701 1.00 170.25 ? 388 ASN A O     1 
ATOM   3116 C  CB    . ASN A 1 388 ? 154.612 159.391 180.743 1.00 170.25 ? 388 ASN A CB    1 
ATOM   3117 C  CG    . ASN A 1 388 ? 154.478 159.137 182.232 1.00 170.25 ? 388 ASN A CG    1 
ATOM   3118 O  OD1   . ASN A 1 388 ? 154.494 160.067 183.037 1.00 170.25 ? 388 ASN A OD1   1 
ATOM   3119 N  ND2   . ASN A 1 388 ? 154.341 157.870 182.605 1.00 170.25 ? 388 ASN A ND2   1 
ATOM   3120 N  N     . GLU A 1 389 ? 156.362 161.860 179.841 1.00 181.24 ? 389 GLU A N     1 
ATOM   3121 C  CA    . GLU A 1 389 ? 157.448 162.808 180.063 1.00 181.24 ? 389 GLU A CA    1 
ATOM   3122 C  C     . GLU A 1 389 ? 156.958 164.249 179.967 1.00 181.24 ? 389 GLU A C     1 
ATOM   3123 O  O     . GLU A 1 389 ? 157.347 165.102 180.775 1.00 181.24 ? 389 GLU A O     1 
ATOM   3124 C  CB    . GLU A 1 389 ? 158.573 162.548 179.065 1.00 181.24 ? 389 GLU A CB    1 
ATOM   3125 C  CG    . GLU A 1 389 ? 159.656 163.605 179.055 1.00 181.24 ? 389 GLU A CG    1 
ATOM   3126 C  CD    . GLU A 1 389 ? 160.983 163.056 178.582 1.00 181.24 ? 389 GLU A CD    1 
ATOM   3127 O  OE1   . GLU A 1 389 ? 161.428 162.029 179.135 1.00 181.24 ? 389 GLU A OE1   1 
ATOM   3128 O  OE2   . GLU A 1 389 ? 161.574 163.641 177.652 1.00 181.24 ? 389 GLU A OE2   1 
ATOM   3129 N  N     . LEU A 1 390 ? 156.103 164.542 178.984 1.00 175.79 ? 390 LEU A N     1 
ATOM   3130 C  CA    . LEU A 1 390 ? 155.569 165.893 178.843 1.00 175.79 ? 390 LEU A CA    1 
ATOM   3131 C  C     . LEU A 1 390 ? 154.773 166.300 180.073 1.00 175.79 ? 390 LEU A C     1 
ATOM   3132 O  O     . LEU A 1 390 ? 154.876 167.440 180.540 1.00 175.79 ? 390 LEU A O     1 
ATOM   3133 C  CB    . LEU A 1 390 ? 154.701 165.998 177.588 1.00 175.79 ? 390 LEU A CB    1 
ATOM   3134 C  CG    . LEU A 1 390 ? 155.384 165.723 176.250 1.00 175.79 ? 390 LEU A CG    1 
ATOM   3135 C  CD1   . LEU A 1 390 ? 154.491 166.151 175.098 1.00 175.79 ? 390 LEU A CD1   1 
ATOM   3136 C  CD2   . LEU A 1 390 ? 156.727 166.429 176.182 1.00 175.79 ? 390 LEU A CD2   1 
ATOM   3137 N  N     . SER A 1 391 ? 153.966 165.383 180.609 1.00 198.87 ? 391 SER A N     1 
ATOM   3138 C  CA    . SER A 1 391 ? 153.278 165.654 181.864 1.00 198.87 ? 391 SER A CA    1 
ATOM   3139 C  C     . SER A 1 391 ? 154.269 165.864 183.001 1.00 198.87 ? 391 SER A C     1 
ATOM   3140 O  O     . SER A 1 391 ? 154.047 166.715 183.870 1.00 198.87 ? 391 SER A O     1 
ATOM   3141 C  CB    . SER A 1 391 ? 152.317 164.514 182.195 1.00 198.87 ? 391 SER A CB    1 
ATOM   3142 O  OG    . SER A 1 391 ? 151.732 163.987 181.017 1.00 198.87 ? 391 SER A OG    1 
ATOM   3143 N  N     . ALA A 1 392 ? 155.364 165.101 183.011 1.00 216.86 ? 392 ALA A N     1 
ATOM   3144 C  CA    . ALA A 1 392 ? 156.394 165.288 184.025 1.00 216.86 ? 392 ALA A CA    1 
ATOM   3145 C  C     . ALA A 1 392 ? 157.135 166.610 183.869 1.00 216.86 ? 392 ALA A C     1 
ATOM   3146 O  O     . ALA A 1 392 ? 157.798 167.049 184.814 1.00 216.86 ? 392 ALA A O     1 
ATOM   3147 C  CB    . ALA A 1 392 ? 157.389 164.127 183.981 1.00 216.86 ? 392 ALA A CB    1 
ATOM   3148 N  N     . LYS A 1 393 ? 157.038 167.255 182.704 1.00 235.75 ? 393 LYS A N     1 
ATOM   3149 C  CA    . LYS A 1 393 ? 157.731 168.521 182.485 1.00 235.75 ? 393 LYS A CA    1 
ATOM   3150 C  C     . LYS A 1 393 ? 157.118 169.681 183.262 1.00 235.75 ? 393 LYS A C     1 
ATOM   3151 O  O     . LYS A 1 393 ? 157.685 170.779 183.234 1.00 235.75 ? 393 LYS A O     1 
ATOM   3152 C  CB    . LYS A 1 393 ? 157.761 168.863 180.994 1.00 235.75 ? 393 LYS A CB    1 
ATOM   3153 C  CG    . LYS A 1 393 ? 158.599 167.910 180.158 1.00 235.75 ? 393 LYS A CG    1 
ATOM   3154 C  CD    . LYS A 1 393 ? 158.991 168.536 178.830 1.00 235.75 ? 393 LYS A CD    1 
ATOM   3155 C  CE    . LYS A 1 393 ? 160.032 169.628 179.023 1.00 235.75 ? 393 LYS A CE    1 
ATOM   3156 N  NZ    . LYS A 1 393 ? 161.328 169.079 179.509 1.00 235.75 ? 393 LYS A NZ    1 
ATOM   3157 N  N     . ARG A 1 394 ? 155.974 169.475 183.916 1.00 251.26 ? 394 ARG A N     1 
ATOM   3158 C  CA    . ARG A 1 394 ? 155.317 170.411 184.829 1.00 251.26 ? 394 ARG A CA    1 
ATOM   3159 C  C     . ARG A 1 394 ? 154.633 171.564 184.094 1.00 251.26 ? 394 ARG A C     1 
ATOM   3160 O  O     . ARG A 1 394 ? 153.898 172.337 184.723 1.00 251.26 ? 394 ARG A O     1 
ATOM   3161 C  CB    . ARG A 1 394 ? 156.300 170.955 185.884 1.00 251.26 ? 394 ARG A CB    1 
ATOM   3162 C  CG    . ARG A 1 394 ? 155.732 171.907 186.934 1.00 251.26 ? 394 ARG A CG    1 
ATOM   3163 C  CD    . ARG A 1 394 ? 156.598 173.153 187.076 1.00 251.26 ? 394 ARG A CD    1 
ATOM   3164 N  NE    . ARG A 1 394 ? 156.937 173.755 185.791 1.00 251.26 ? 394 ARG A NE    1 
ATOM   3165 C  CZ    . ARG A 1 394 ? 156.081 174.396 185.007 1.00 251.26 ? 394 ARG A CZ    1 
ATOM   3166 N  NH1   . ARG A 1 394 ? 154.813 174.557 185.351 1.00 251.26 ? 394 ARG A NH1   1 
ATOM   3167 N  NH2   . ARG A 1 394 ? 156.507 174.891 183.848 1.00 251.26 ? 394 ARG A NH2   1 
ATOM   3168 N  N     . ASP A 1 395 ? 154.796 171.673 182.776 1.00 247.18 ? 395 ASP A N     1 
ATOM   3169 C  CA    . ASP A 1 395 ? 154.201 172.774 182.034 1.00 247.18 ? 395 ASP A CA    1 
ATOM   3170 C  C     . ASP A 1 395 ? 152.676 172.738 182.143 1.00 247.18 ? 395 ASP A C     1 
ATOM   3171 O  O     . ASP A 1 395 ? 152.065 171.690 182.370 1.00 247.18 ? 395 ASP A O     1 
ATOM   3172 C  CB    . ASP A 1 395 ? 154.634 172.727 180.568 1.00 247.18 ? 395 ASP A CB    1 
ATOM   3173 C  CG    . ASP A 1 395 ? 154.214 173.962 179.793 1.00 247.18 ? 395 ASP A CG    1 
ATOM   3174 O  OD1   . ASP A 1 395 ? 154.643 175.074 180.167 1.00 247.18 ? 395 ASP A OD1   1 
ATOM   3175 O  OD2   . ASP A 1 395 ? 153.456 173.821 178.810 1.00 247.18 ? 395 ASP A OD2   1 
ATOM   3176 N  N     . ASP A 1 396 ? 152.067 173.914 181.983 1.00 249.40 ? 396 ASP A N     1 
ATOM   3177 C  CA    . ASP A 1 396 ? 150.641 174.070 182.256 1.00 249.40 ? 396 ASP A CA    1 
ATOM   3178 C  C     . ASP A 1 396 ? 149.791 173.198 181.338 1.00 249.40 ? 396 ASP A C     1 
ATOM   3179 O  O     . ASP A 1 396 ? 148.842 172.545 181.786 1.00 249.40 ? 396 ASP A O     1 
ATOM   3180 C  CB    . ASP A 1 396 ? 150.245 175.540 182.118 1.00 249.40 ? 396 ASP A CB    1 
ATOM   3181 C  CG    . ASP A 1 396 ? 150.732 176.156 180.820 1.00 249.40 ? 396 ASP A CG    1 
ATOM   3182 O  OD1   . ASP A 1 396 ? 151.508 175.491 180.101 1.00 249.40 ? 396 ASP A OD1   1 
ATOM   3183 O  OD2   . ASP A 1 396 ? 150.338 177.301 180.517 1.00 249.40 ? 396 ASP A OD2   1 
ATOM   3184 N  N     . ASP A 1 397 ? 150.119 173.171 180.046 1.00 243.80 ? 397 ASP A N     1 
ATOM   3185 C  CA    . ASP A 1 397 ? 149.284 172.475 179.076 1.00 243.80 ? 397 ASP A CA    1 
ATOM   3186 C  C     . ASP A 1 397 ? 149.430 170.960 179.127 1.00 243.80 ? 397 ASP A C     1 
ATOM   3187 O  O     . ASP A 1 397 ? 148.664 170.260 178.458 1.00 243.80 ? 397 ASP A O     1 
ATOM   3188 C  CB    . ASP A 1 397 ? 149.601 172.966 177.661 1.00 243.80 ? 397 ASP A CB    1 
ATOM   3189 C  CG    . ASP A 1 397 ? 149.351 174.449 177.489 1.00 243.80 ? 397 ASP A CG    1 
ATOM   3190 O  OD1   . ASP A 1 397 ? 148.178 174.839 177.311 1.00 243.80 ? 397 ASP A OD1   1 
ATOM   3191 O  OD2   . ASP A 1 397 ? 150.326 175.228 177.530 1.00 243.80 ? 397 ASP A OD2   1 
ATOM   3192 N  N     . PHE A 1 398 ? 150.397 170.436 179.880 1.00 231.33 ? 398 PHE A N     1 
ATOM   3193 C  CA    . PHE A 1 398 ? 150.639 169.002 179.937 1.00 231.33 ? 398 PHE A CA    1 
ATOM   3194 C  C     . PHE A 1 398 ? 150.480 168.412 181.331 1.00 231.33 ? 398 PHE A C     1 
ATOM   3195 O  O     . PHE A 1 398 ? 150.505 167.184 181.466 1.00 231.33 ? 398 PHE A O     1 
ATOM   3196 C  CB    . PHE A 1 398 ? 152.050 168.666 179.414 1.00 231.33 ? 398 PHE A CB    1 
ATOM   3197 C  CG    . PHE A 1 398 ? 152.560 169.603 178.345 1.00 231.33 ? 398 PHE A CG    1 
ATOM   3198 C  CD1   . PHE A 1 398 ? 151.761 169.981 177.274 1.00 231.33 ? 398 PHE A CD1   1 
ATOM   3199 C  CD2   . PHE A 1 398 ? 153.845 170.114 178.420 1.00 231.33 ? 398 PHE A CD2   1 
ATOM   3200 C  CE1   . PHE A 1 398 ? 152.234 170.844 176.304 1.00 231.33 ? 398 PHE A CE1   1 
ATOM   3201 C  CE2   . PHE A 1 398 ? 154.325 170.977 177.452 1.00 231.33 ? 398 PHE A CE2   1 
ATOM   3202 C  CZ    . PHE A 1 398 ? 153.518 171.341 176.393 1.00 231.33 ? 398 PHE A CZ    1 
ATOM   3203 N  N     . SER A 1 399 ? 150.313 169.243 182.361 1.00 211.72 ? 399 SER A N     1 
ATOM   3204 C  CA    . SER A 1 399 ? 150.274 168.734 183.729 1.00 211.72 ? 399 SER A CA    1 
ATOM   3205 C  C     . SER A 1 399 ? 149.055 167.848 183.967 1.00 211.72 ? 399 SER A C     1 
ATOM   3206 O  O     . SER A 1 399 ? 149.136 166.853 184.696 1.00 211.72 ? 399 SER A O     1 
ATOM   3207 C  CB    . SER A 1 399 ? 150.290 169.897 184.719 1.00 211.72 ? 399 SER A CB    1 
ATOM   3208 O  OG    . SER A 1 399 ? 149.051 170.583 184.717 1.00 211.72 ? 399 SER A OG    1 
ATOM   3209 N  N     . PHE A 1 400 ? 147.920 168.194 183.367 1.00 191.77 ? 400 PHE A N     1 
ATOM   3210 C  CA    . PHE A 1 400 ? 146.668 167.489 183.611 1.00 191.77 ? 400 PHE A CA    1 
ATOM   3211 C  C     . PHE A 1 400 ? 146.554 166.177 182.846 1.00 191.77 ? 400 PHE A C     1 
ATOM   3212 O  O     . PHE A 1 400 ? 145.576 165.448 183.046 1.00 191.77 ? 400 PHE A O     1 
ATOM   3213 C  CB    . PHE A 1 400 ? 145.485 168.388 183.242 1.00 191.77 ? 400 PHE A CB    1 
ATOM   3214 C  CG    . PHE A 1 400 ? 145.541 168.907 181.835 1.00 191.77 ? 400 PHE A CG    1 
ATOM   3215 C  CD1   . PHE A 1 400 ? 145.039 168.155 180.785 1.00 191.77 ? 400 PHE A CD1   1 
ATOM   3216 C  CD2   . PHE A 1 400 ? 146.109 170.137 181.560 1.00 191.77 ? 400 PHE A CD2   1 
ATOM   3217 C  CE1   . PHE A 1 400 ? 145.095 168.625 179.490 1.00 191.77 ? 400 PHE A CE1   1 
ATOM   3218 C  CE2   . PHE A 1 400 ? 146.168 170.611 180.267 1.00 191.77 ? 400 PHE A CE2   1 
ATOM   3219 C  CZ    . PHE A 1 400 ? 145.660 169.854 179.231 1.00 191.77 ? 400 PHE A CZ    1 
ATOM   3220 N  N     . ILE A 1 401 ? 147.507 165.864 181.976 1.00 191.16 ? 401 ILE A N     1 
ATOM   3221 C  CA    . ILE A 1 401 ? 147.373 164.725 181.073 1.00 191.16 ? 401 ILE A CA    1 
ATOM   3222 C  C     . ILE A 1 401 ? 147.716 163.442 181.822 1.00 191.16 ? 401 ILE A C     1 
ATOM   3223 O  O     . ILE A 1 401 ? 148.783 163.333 182.435 1.00 191.16 ? 401 ILE A O     1 
ATOM   3224 C  CB    . ILE A 1 401 ? 148.265 164.899 179.835 1.00 191.16 ? 401 ILE A CB    1 
ATOM   3225 C  CG1   . ILE A 1 401 ? 147.533 165.712 178.765 1.00 191.16 ? 401 ILE A CG1   1 
ATOM   3226 C  CG2   . ILE A 1 401 ? 148.680 163.547 179.273 1.00 191.16 ? 401 ILE A CG2   1 
ATOM   3227 C  CD1   . ILE A 1 401 ? 146.506 164.922 177.990 1.00 191.16 ? 401 ILE A CD1   1 
ATOM   3228 N  N     . LYS A 1 402 ? 146.801 162.477 181.787 1.00 184.87 ? 402 LYS A N     1 
ATOM   3229 C  CA    . LYS A 1 402 ? 147.057 161.112 182.231 1.00 184.87 ? 402 LYS A CA    1 
ATOM   3230 C  C     . LYS A 1 402 ? 147.028 160.203 181.011 1.00 184.87 ? 402 LYS A C     1 
ATOM   3231 O  O     . LYS A 1 402 ? 146.104 160.288 180.195 1.00 184.87 ? 402 LYS A O     1 
ATOM   3232 C  CB    . LYS A 1 402 ? 146.026 160.642 183.264 1.00 184.87 ? 402 LYS A CB    1 
ATOM   3233 C  CG    . LYS A 1 402 ? 145.614 161.651 184.338 1.00 184.87 ? 402 LYS A CG    1 
ATOM   3234 C  CD    . LYS A 1 402 ? 146.792 162.432 184.906 1.00 184.87 ? 402 LYS A CD    1 
ATOM   3235 C  CE    . LYS A 1 402 ? 146.323 163.691 185.614 1.00 184.87 ? 402 LYS A CE    1 
ATOM   3236 N  NZ    . LYS A 1 402 ? 147.388 164.728 185.669 1.00 184.87 ? 402 LYS A NZ    1 
ATOM   3237 N  N     . CYS A 1 403 ? 148.032 159.339 180.886 1.00 175.16 ? 403 CYS A N     1 
ATOM   3238 C  CA    . CYS A 1 403 ? 148.180 158.507 179.701 1.00 175.16 ? 403 CYS A CA    1 
ATOM   3239 C  C     . CYS A 1 403 ? 148.360 157.047 180.091 1.00 175.16 ? 403 CYS A C     1 
ATOM   3240 O  O     . CYS A 1 403 ? 149.028 156.734 181.080 1.00 175.16 ? 403 CYS A O     1 
ATOM   3241 C  CB    . CYS A 1 403 ? 149.366 158.967 178.848 1.00 175.16 ? 403 CYS A CB    1 
ATOM   3242 S  SG    . CYS A 1 403 ? 149.173 158.633 177.082 1.00 175.16 ? 403 CYS A SG    1 
ATOM   3243 N  N     . ASP A 1 404 ? 147.755 156.161 179.301 1.00 158.77 ? 404 ASP A N     1 
ATOM   3244 C  CA    . ASP A 1 404 ? 147.901 154.724 179.474 1.00 158.77 ? 404 ASP A CA    1 
ATOM   3245 C  C     . ASP A 1 404 ? 147.774 154.058 178.112 1.00 158.77 ? 404 ASP A C     1 
ATOM   3246 O  O     . ASP A 1 404 ? 147.262 154.647 177.157 1.00 158.77 ? 404 ASP A O     1 
ATOM   3247 C  CB    . ASP A 1 404 ? 146.865 154.158 180.450 1.00 158.77 ? 404 ASP A CB    1 
ATOM   3248 C  CG    . ASP A 1 404 ? 147.446 153.886 181.823 1.00 158.77 ? 404 ASP A CG    1 
ATOM   3249 O  OD1   . ASP A 1 404 ? 148.653 153.580 181.907 1.00 158.77 ? 404 ASP A OD1   1 
ATOM   3250 O  OD2   . ASP A 1 404 ? 146.695 153.974 182.818 1.00 158.77 ? 404 ASP A OD2   1 
ATOM   3251 N  N     . PHE A 1 405 ? 148.252 152.819 178.032 1.00 154.92 ? 405 PHE A N     1 
ATOM   3252 C  CA    . PHE A 1 405 ? 148.259 152.081 176.779 1.00 154.92 ? 405 PHE A CA    1 
ATOM   3253 C  C     . PHE A 1 405 ? 147.802 150.650 177.016 1.00 154.92 ? 405 PHE A C     1 
ATOM   3254 O  O     . PHE A 1 405 ? 148.059 150.065 178.072 1.00 154.92 ? 405 PHE A O     1 
ATOM   3255 C  CB    . PHE A 1 405 ? 149.651 152.094 176.131 1.00 154.92 ? 405 PHE A CB    1 
ATOM   3256 C  CG    . PHE A 1 405 ? 150.599 151.078 176.703 1.00 154.92 ? 405 PHE A CG    1 
ATOM   3257 C  CD1   . PHE A 1 405 ? 151.008 151.159 178.024 1.00 154.92 ? 405 PHE A CD1   1 
ATOM   3258 C  CD2   . PHE A 1 405 ? 151.086 150.047 175.919 1.00 154.92 ? 405 PHE A CD2   1 
ATOM   3259 C  CE1   . PHE A 1 405 ? 151.879 150.227 178.553 1.00 154.92 ? 405 PHE A CE1   1 
ATOM   3260 C  CE2   . PHE A 1 405 ? 151.957 149.113 176.441 1.00 154.92 ? 405 PHE A CE2   1 
ATOM   3261 C  CZ    . PHE A 1 405 ? 152.354 149.203 177.760 1.00 154.92 ? 405 PHE A CZ    1 
ATOM   3262 N  N     . VAL A 1 406 ? 147.114 150.095 176.021 1.00 152.78 ? 406 VAL A N     1 
ATOM   3263 C  CA    . VAL A 1 406 ? 146.668 148.705 176.043 1.00 152.78 ? 406 VAL A CA    1 
ATOM   3264 C  C     . VAL A 1 406 ? 146.922 148.096 174.671 1.00 152.78 ? 406 VAL A C     1 
ATOM   3265 O  O     . VAL A 1 406 ? 146.551 148.680 173.648 1.00 152.78 ? 406 VAL A O     1 
ATOM   3266 C  CB    . VAL A 1 406 ? 145.181 148.583 176.425 1.00 152.78 ? 406 VAL A CB    1 
ATOM   3267 C  CG1   . VAL A 1 406 ? 145.021 148.609 177.933 1.00 152.78 ? 406 VAL A CG1   1 
ATOM   3268 C  CG2   . VAL A 1 406 ? 144.378 149.702 175.790 1.00 152.78 ? 406 VAL A CG2   1 
ATOM   3269 N  N     . VAL A 1 407 ? 147.554 146.921 174.650 1.00 169.83 ? 407 VAL A N     1 
ATOM   3270 C  CA    . VAL A 1 407 ? 147.896 146.222 173.418 1.00 169.83 ? 407 VAL A CA    1 
ATOM   3271 C  C     . VAL A 1 407 ? 147.665 144.730 173.619 1.00 169.83 ? 407 VAL A C     1 
ATOM   3272 O  O     . VAL A 1 407 ? 147.447 144.254 174.734 1.00 169.83 ? 407 VAL A O     1 
ATOM   3273 C  CB    . VAL A 1 407 ? 149.354 146.483 172.983 1.00 169.83 ? 407 VAL A CB    1 
ATOM   3274 C  CG1   . VAL A 1 407 ? 149.493 147.873 172.385 1.00 169.83 ? 407 VAL A CG1   1 
ATOM   3275 C  CG2   . VAL A 1 407 ? 150.295 146.309 174.162 1.00 169.83 ? 407 VAL A CG2   1 
ATOM   3276 N  N     . GLY A 1 408 ? 147.714 143.990 172.513 1.00 147.13 ? 408 GLY A N     1 
ATOM   3277 C  CA    . GLY A 1 408 ? 147.544 142.552 172.584 1.00 147.13 ? 408 GLY A CA    1 
ATOM   3278 C  C     . GLY A 1 408 ? 148.690 141.878 173.311 1.00 147.13 ? 408 GLY A C     1 
ATOM   3279 O  O     . GLY A 1 408 ? 149.839 142.316 173.263 1.00 147.13 ? 408 GLY A O     1 
ATOM   3280 N  N     . HIS A 1 409 ? 148.365 140.785 173.992 1.00 168.37 ? 409 HIS A N     1 
ATOM   3281 C  CA    . HIS A 1 409 ? 149.323 140.061 174.813 1.00 168.37 ? 409 HIS A CA    1 
ATOM   3282 C  C     . HIS A 1 409 ? 149.724 138.767 174.120 1.00 168.37 ? 409 HIS A C     1 
ATOM   3283 O  O     . HIS A 1 409 ? 148.875 138.062 173.565 1.00 168.37 ? 409 HIS A O     1 
ATOM   3284 C  CB    . HIS A 1 409 ? 148.737 139.764 176.195 1.00 168.37 ? 409 HIS A CB    1 
ATOM   3285 C  CG    . HIS A 1 409 ? 147.591 138.802 176.171 1.00 168.37 ? 409 HIS A CG    1 
ATOM   3286 N  ND1   . HIS A 1 409 ? 146.359 139.124 175.643 1.00 168.37 ? 409 HIS A ND1   1 
ATOM   3287 C  CD2   . HIS A 1 409 ? 147.488 137.526 176.612 1.00 168.37 ? 409 HIS A CD2   1 
ATOM   3288 C  CE1   . HIS A 1 409 ? 145.548 138.088 175.758 1.00 168.37 ? 409 HIS A CE1   1 
ATOM   3289 N  NE2   . HIS A 1 409 ? 146.208 137.105 176.343 1.00 168.37 ? 409 HIS A NE2   1 
ATOM   3290 N  N     . ASN A 1 410 ? 151.021 138.466 174.146 1.00 209.17 ? 410 ASN A N     1 
ATOM   3291 C  CA    . ASN A 1 410 ? 151.557 137.206 173.638 1.00 209.17 ? 410 ASN A CA    1 
ATOM   3292 C  C     . ASN A 1 410 ? 152.438 136.619 174.737 1.00 209.17 ? 410 ASN A C     1 
ATOM   3293 O  O     . ASN A 1 410 ? 153.653 136.837 174.749 1.00 209.17 ? 410 ASN A O     1 
ATOM   3294 C  CB    . ASN A 1 410 ? 152.338 137.411 172.344 1.00 209.17 ? 410 ASN A CB    1 
ATOM   3295 C  CG    . ASN A 1 410 ? 151.474 137.951 171.221 1.00 209.17 ? 410 ASN A CG    1 
ATOM   3296 O  OD1   . ASN A 1 410 ? 150.295 137.618 171.112 1.00 209.17 ? 410 ASN A OD1   1 
ATOM   3297 N  ND2   . ASN A 1 410 ? 152.061 138.789 170.374 1.00 209.17 ? 410 ASN A ND2   1 
ATOM   3298 N  N     . SER A 1 411 ? 151.822 135.881 175.657 1.00 227.36 ? 411 SER A N     1 
ATOM   3299 C  CA    . SER A 1 411 ? 152.530 135.304 176.790 1.00 227.36 ? 411 SER A CA    1 
ATOM   3300 C  C     . SER A 1 411 ? 153.481 134.217 176.307 1.00 227.36 ? 411 SER A C     1 
ATOM   3301 O  O     . SER A 1 411 ? 153.113 133.388 175.468 1.00 227.36 ? 411 SER A O     1 
ATOM   3302 C  CB    . SER A 1 411 ? 151.544 134.728 177.808 1.00 227.36 ? 411 SER A CB    1 
ATOM   3303 O  OG    . SER A 1 411 ? 151.247 133.374 177.518 1.00 227.36 ? 411 SER A OG    1 
ATOM   3304 N  N     . SER A 1 412 ? 154.700 134.226 176.839 1.00 238.02 ? 412 SER A N     1 
ATOM   3305 C  CA    . SER A 1 412 ? 155.722 133.266 176.457 1.00 238.02 ? 412 SER A CA    1 
ATOM   3306 C  C     . SER A 1 412 ? 155.973 132.300 177.604 1.00 238.02 ? 412 SER A C     1 
ATOM   3307 O  O     . SER A 1 412 ? 156.341 132.743 178.703 1.00 238.02 ? 412 SER A O     1 
ATOM   3308 C  CB    . SER A 1 412 ? 157.014 133.983 176.070 1.00 238.02 ? 412 SER A CB    1 
ATOM   3309 O  OG    . SER A 1 412 ? 157.955 133.079 175.519 1.00 238.02 ? 412 SER A OG    1 
ATOM   3310 N  N     . PRO A 1 413 ? 155.786 130.990 177.410 1.00 249.43 ? 413 PRO A N     1 
ATOM   3311 C  CA    . PRO A 1 413 ? 156.099 130.037 178.486 1.00 249.43 ? 413 PRO A CA    1 
ATOM   3312 C  C     . PRO A 1 413 ? 157.588 130.020 178.787 1.00 249.43 ? 413 PRO A C     1 
ATOM   3313 O  O     . PRO A 1 413 ? 158.000 130.139 179.945 1.00 249.43 ? 413 PRO A O     1 
ATOM   3314 C  CB    . PRO A 1 413 ? 155.611 128.688 177.939 1.00 249.43 ? 413 PRO A CB    1 
ATOM   3315 C  CG    . PRO A 1 413 ? 155.358 128.884 176.486 1.00 249.43 ? 413 PRO A CG    1 
ATOM   3316 C  CD    . PRO A 1 413 ? 155.426 130.336 176.141 1.00 249.43 ? 413 PRO A CD    1 
ATOM   3317 N  N     . SER A 1 414 ? 158.402 129.873 177.745 1.00 268.24 ? 414 SER A N     1 
ATOM   3318 C  CA    . SER A 1 414 ? 159.829 130.112 177.868 1.00 268.24 ? 414 SER A CA    1 
ATOM   3319 C  C     . SER A 1 414 ? 160.085 131.610 178.023 1.00 268.24 ? 414 SER A C     1 
ATOM   3320 O  O     . SER A 1 414 ? 159.193 132.442 177.833 1.00 268.24 ? 414 SER A O     1 
ATOM   3321 C  CB    . SER A 1 414 ? 160.569 129.553 176.656 1.00 268.24 ? 414 SER A CB    1 
ATOM   3322 O  OG    . SER A 1 414 ? 159.881 129.870 175.460 1.00 268.24 ? 414 SER A OG    1 
ATOM   3323 N  N     . SER A 1 415 ? 161.319 131.958 178.392 1.00 281.02 ? 415 SER A N     1 
ATOM   3324 C  CA    . SER A 1 415 ? 161.619 133.356 178.687 1.00 281.02 ? 415 SER A CA    1 
ATOM   3325 C  C     . SER A 1 415 ? 161.413 134.238 177.462 1.00 281.02 ? 415 SER A C     1 
ATOM   3326 O  O     . SER A 1 415 ? 160.444 135.003 177.416 1.00 281.02 ? 415 SER A O     1 
ATOM   3327 C  CB    . SER A 1 415 ? 163.052 133.497 179.204 1.00 281.02 ? 415 SER A CB    1 
ATOM   3328 O  OG    . SER A 1 415 ? 163.366 134.852 179.474 1.00 281.02 ? 415 SER A OG    1 
ATOM   3329 N  N     . LYS A 1 416 ? 162.299 134.109 176.464 1.00 263.93 ? 416 LYS A N     1 
ATOM   3330 C  CA    . LYS A 1 416 ? 162.166 134.726 175.144 1.00 263.93 ? 416 LYS A CA    1 
ATOM   3331 C  C     . LYS A 1 416 ? 161.495 136.093 175.212 1.00 263.93 ? 416 LYS A C     1 
ATOM   3332 O  O     . LYS A 1 416 ? 160.459 136.319 174.577 1.00 263.93 ? 416 LYS A O     1 
ATOM   3333 C  CB    . LYS A 1 416 ? 161.416 133.783 174.203 1.00 263.93 ? 416 LYS A CB    1 
ATOM   3334 C  CG    . LYS A 1 416 ? 162.182 132.489 173.948 1.00 263.93 ? 416 LYS A CG    1 
ATOM   3335 C  CD    . LYS A 1 416 ? 161.363 131.477 173.176 1.00 263.93 ? 416 LYS A CD    1 
ATOM   3336 C  CE    . LYS A 1 416 ? 162.061 130.127 173.113 1.00 263.93 ? 416 LYS A CE    1 
ATOM   3337 N  NZ    . LYS A 1 416 ? 161.242 129.115 172.392 1.00 263.93 ? 416 LYS A NZ    1 
ATOM   3338 N  N     . GLU A 1 417 ? 162.084 137.002 175.987 1.00 258.08 ? 417 GLU A N     1 
ATOM   3339 C  CA    . GLU A 1 417 ? 161.374 138.190 176.443 1.00 258.08 ? 417 GLU A CA    1 
ATOM   3340 C  C     . GLU A 1 417 ? 160.998 139.112 175.291 1.00 258.08 ? 417 GLU A C     1 
ATOM   3341 O  O     . GLU A 1 417 ? 161.755 139.288 174.332 1.00 258.08 ? 417 GLU A O     1 
ATOM   3342 C  CB    . GLU A 1 417 ? 162.229 138.948 177.459 1.00 258.08 ? 417 GLU A CB    1 
ATOM   3343 C  CG    . GLU A 1 417 ? 161.515 140.104 178.142 1.00 258.08 ? 417 GLU A CG    1 
ATOM   3344 C  CD    . GLU A 1 417 ? 160.372 139.645 179.026 1.00 258.08 ? 417 GLU A CD    1 
ATOM   3345 O  OE1   . GLU A 1 417 ? 160.407 138.491 179.501 1.00 258.08 ? 417 GLU A OE1   1 
ATOM   3346 O  OE2   . GLU A 1 417 ? 159.433 140.440 179.245 1.00 258.08 ? 417 GLU A OE2   1 
ATOM   3347 N  N     . LYS A 1 418 ? 159.810 139.702 175.396 1.00 238.14 ? 418 LYS A N     1 
ATOM   3348 C  CA    . LYS A 1 418 ? 159.361 140.777 174.524 1.00 238.14 ? 418 LYS A CA    1 
ATOM   3349 C  C     . LYS A 1 418 ? 159.442 142.087 175.295 1.00 238.14 ? 418 LYS A C     1 
ATOM   3350 O  O     . LYS A 1 418 ? 159.128 142.125 176.489 1.00 238.14 ? 418 LYS A O     1 
ATOM   3351 C  CB    . LYS A 1 418 ? 157.933 140.532 174.032 1.00 238.14 ? 418 LYS A CB    1 
ATOM   3352 C  CG    . LYS A 1 418 ? 157.767 139.280 173.185 1.00 238.14 ? 418 LYS A CG    1 
ATOM   3353 C  CD    . LYS A 1 418 ? 158.451 139.433 171.836 1.00 238.14 ? 418 LYS A CD    1 
ATOM   3354 C  CE    . LYS A 1 418 ? 158.277 138.187 170.982 1.00 238.14 ? 418 LYS A CE    1 
ATOM   3355 N  NZ    . LYS A 1 418 ? 159.071 137.039 171.502 1.00 238.14 ? 418 LYS A NZ    1 
ATOM   3356 N  N     . SER A 1 419 ? 159.871 143.151 174.613 1.00 228.11 ? 419 SER A N     1 
ATOM   3357 C  CA    . SER A 1 419 ? 160.073 144.431 175.289 1.00 228.11 ? 419 SER A CA    1 
ATOM   3358 C  C     . SER A 1 419 ? 158.767 144.978 175.855 1.00 228.11 ? 419 SER A C     1 
ATOM   3359 O  O     . SER A 1 419 ? 158.742 145.516 176.968 1.00 228.11 ? 419 SER A O     1 
ATOM   3360 C  CB    . SER A 1 419 ? 160.704 145.436 174.327 1.00 228.11 ? 419 SER A CB    1 
ATOM   3361 O  OG    . SER A 1 419 ? 162.020 145.046 173.975 1.00 228.11 ? 419 SER A OG    1 
ATOM   3362 N  N     . THR A 1 420 ? 157.675 144.855 175.105 1.00 218.41 ? 420 THR A N     1 
ATOM   3363 C  CA    . THR A 1 420 ? 156.390 145.357 175.568 1.00 218.41 ? 420 THR A CA    1 
ATOM   3364 C  C     . THR A 1 420 ? 155.902 144.560 176.772 1.00 218.41 ? 420 THR A C     1 
ATOM   3365 O  O     . THR A 1 420 ? 156.089 143.342 176.851 1.00 218.41 ? 420 THR A O     1 
ATOM   3366 C  CB    . THR A 1 420 ? 155.357 145.290 174.443 1.00 218.41 ? 420 THR A CB    1 
ATOM   3367 O  OG1   . THR A 1 420 ? 155.289 143.953 173.932 1.00 218.41 ? 420 THR A OG1   1 
ATOM   3368 C  CG2   . THR A 1 420 ? 155.738 146.238 173.316 1.00 218.41 ? 420 THR A CG2   1 
ATOM   3369 N  N     . GLU A 1 421 ? 155.271 145.256 177.713 1.00 227.74 ? 421 GLU A N     1 
ATOM   3370 C  CA    . GLU A 1 421 ? 154.772 144.656 178.941 1.00 227.74 ? 421 GLU A CA    1 
ATOM   3371 C  C     . GLU A 1 421 ? 153.252 144.579 178.891 1.00 227.74 ? 421 GLU A C     1 
ATOM   3372 O  O     . GLU A 1 421 ? 152.586 145.584 178.619 1.00 227.74 ? 421 GLU A O     1 
ATOM   3373 C  CB    . GLU A 1 421 ? 155.214 145.467 180.160 1.00 227.74 ? 421 GLU A CB    1 
ATOM   3374 C  CG    . GLU A 1 421 ? 156.667 145.908 180.121 1.00 227.74 ? 421 GLU A CG    1 
ATOM   3375 C  CD    . GLU A 1 421 ? 156.954 147.042 181.087 1.00 227.74 ? 421 GLU A CD    1 
ATOM   3376 O  OE1   . GLU A 1 421 ? 155.991 147.598 181.656 1.00 227.74 ? 421 GLU A OE1   1 
ATOM   3377 O  OE2   . GLU A 1 421 ? 158.142 147.378 181.277 1.00 227.74 ? 421 GLU A OE2   1 
ATOM   3378 N  N     . MET A 1 422 ? 152.707 143.393 179.158 1.00 205.71 ? 422 MET A N     1 
ATOM   3379 C  CA    . MET A 1 422 ? 151.261 143.220 179.171 1.00 205.71 ? 422 MET A CA    1 
ATOM   3380 C  C     . MET A 1 422 ? 150.912 141.934 179.905 1.00 205.71 ? 422 MET A C     1 
ATOM   3381 O  O     . MET A 1 422 ? 151.658 140.951 179.857 1.00 205.71 ? 422 MET A O     1 
ATOM   3382 C  CB    . MET A 1 422 ? 150.683 143.196 177.751 1.00 205.71 ? 422 MET A CB    1 
ATOM   3383 C  CG    . MET A 1 422 ? 149.217 143.614 177.640 1.00 205.71 ? 422 MET A CG    1 
ATOM   3384 S  SD    . MET A 1 422 ? 148.848 145.271 178.261 1.00 205.71 ? 422 MET A SD    1 
ATOM   3385 C  CE    . MET A 1 422 ? 148.307 144.932 179.937 1.00 205.71 ? 422 MET A CE    1 
ATOM   3386 N  N     . ASN A 1 423 ? 149.768 141.956 180.585 1.00 189.59 ? 423 ASN A N     1 
ATOM   3387 C  CA    . ASN A 1 423 ? 149.238 140.782 181.263 1.00 189.59 ? 423 ASN A CA    1 
ATOM   3388 C  C     . ASN A 1 423 ? 147.723 140.906 181.323 1.00 189.59 ? 423 ASN A C     1 
ATOM   3389 O  O     . ASN A 1 423 ? 147.185 142.011 181.425 1.00 189.59 ? 423 ASN A O     1 
ATOM   3390 C  CB    . ASN A 1 423 ? 149.820 140.626 182.672 1.00 189.59 ? 423 ASN A CB    1 
ATOM   3391 C  CG    . ASN A 1 423 ? 149.599 139.240 183.247 1.00 189.59 ? 423 ASN A CG    1 
ATOM   3392 O  OD1   . ASN A 1 423 ? 148.745 138.488 182.777 1.00 189.59 ? 423 ASN A OD1   1 
ATOM   3393 N  ND2   . ASN A 1 423 ? 150.371 138.895 184.270 1.00 189.59 ? 423 ASN A ND2   1 
ATOM   3394 N  N     . SER A 1 424 ? 147.043 139.757 181.262 1.00 165.48 ? 424 SER A N     1 
ATOM   3395 C  CA    . SER A 1 424 ? 145.583 139.760 181.266 1.00 165.48 ? 424 SER A CA    1 
ATOM   3396 C  C     . SER A 1 424 ? 145.036 140.370 182.549 1.00 165.48 ? 424 SER A C     1 
ATOM   3397 O  O     . SER A 1 424 ? 144.099 141.178 182.512 1.00 165.48 ? 424 SER A O     1 
ATOM   3398 C  CB    . SER A 1 424 ? 145.055 138.338 181.080 1.00 165.48 ? 424 SER A CB    1 
ATOM   3399 O  OG    . SER A 1 424 ? 143.653 138.287 181.280 1.00 165.48 ? 424 SER A OG    1 
ATOM   3400 N  N     . LYS A 1 425 ? 145.605 139.993 183.696 1.00 174.89 ? 425 LYS A N     1 
ATOM   3401 C  CA    . LYS A 1 425 ? 145.229 140.631 184.952 1.00 174.89 ? 425 LYS A CA    1 
ATOM   3402 C  C     . LYS A 1 425 ? 145.545 142.120 184.915 1.00 174.89 ? 425 LYS A C     1 
ATOM   3403 O  O     . LYS A 1 425 ? 144.720 142.957 185.302 1.00 174.89 ? 425 LYS A O     1 
ATOM   3404 C  CB    . LYS A 1 425 ? 145.947 139.946 186.115 1.00 174.89 ? 425 LYS A CB    1 
ATOM   3405 C  CG    . LYS A 1 425 ? 146.085 140.801 187.363 1.00 174.89 ? 425 LYS A CG    1 
ATOM   3406 C  CD    . LYS A 1 425 ? 146.638 139.989 188.522 1.00 174.89 ? 425 LYS A CD    1 
ATOM   3407 C  CE    . LYS A 1 425 ? 148.070 139.553 188.257 1.00 174.89 ? 425 LYS A CE    1 
ATOM   3408 N  NZ    . LYS A 1 425 ? 148.976 140.715 188.052 1.00 174.89 ? 425 LYS A NZ    1 
ATOM   3409 N  N     . LYS A 1 426 ? 146.737 142.472 184.424 1.00 174.66 ? 426 LYS A N     1 
ATOM   3410 C  CA    . LYS A 1 426 ? 147.082 143.878 184.258 1.00 174.66 ? 426 LYS A CA    1 
ATOM   3411 C  C     . LYS A 1 426 ? 146.191 144.549 183.222 1.00 174.66 ? 426 LYS A C     1 
ATOM   3412 O  O     . LYS A 1 426 ? 145.851 145.728 183.367 1.00 174.66 ? 426 LYS A O     1 
ATOM   3413 C  CB    . LYS A 1 426 ? 148.555 144.012 183.873 1.00 174.66 ? 426 LYS A CB    1 
ATOM   3414 C  CG    . LYS A 1 426 ? 149.021 145.446 183.671 1.00 174.66 ? 426 LYS A CG    1 
ATOM   3415 C  CD    . LYS A 1 426 ? 150.529 145.524 183.490 1.00 174.66 ? 426 LYS A CD    1 
ATOM   3416 C  CE    . LYS A 1 426 ? 151.045 144.401 182.605 1.00 174.66 ? 426 LYS A CE    1 
ATOM   3417 N  NZ    . LYS A 1 426 ? 152.465 144.066 182.901 1.00 174.66 ? 426 LYS A NZ    1 
ATOM   3418 N  N     . GLN A 1 427 ? 145.799 143.817 182.176 1.00 169.77 ? 427 GLN A N     1 
ATOM   3419 C  CA    . GLN A 1 427 ? 144.890 144.376 181.181 1.00 169.77 ? 427 GLN A CA    1 
ATOM   3420 C  C     . GLN A 1 427 ? 143.561 144.768 181.814 1.00 169.77 ? 427 GLN A C     1 
ATOM   3421 O  O     . GLN A 1 427 ? 143.061 145.880 181.605 1.00 169.77 ? 427 GLN A O     1 
ATOM   3422 C  CB    . GLN A 1 427 ? 144.671 143.370 180.051 1.00 169.77 ? 427 GLN A CB    1 
ATOM   3423 C  CG    . GLN A 1 427 ? 144.179 143.984 178.753 1.00 169.77 ? 427 GLN A CG    1 
ATOM   3424 C  CD    . GLN A 1 427 ? 144.293 143.029 177.581 1.00 169.77 ? 427 GLN A CD    1 
ATOM   3425 O  OE1   . GLN A 1 427 ? 144.703 141.881 177.741 1.00 169.77 ? 427 GLN A OE1   1 
ATOM   3426 N  NE2   . GLN A 1 427 ? 143.927 143.500 176.395 1.00 169.77 ? 427 GLN A NE2   1 
ATOM   3427 N  N     . LYS A 1 428 ? 142.978 143.866 182.608 1.00 175.46 ? 428 LYS A N     1 
ATOM   3428 C  CA    . LYS A 1 428 ? 141.703 144.181 183.241 1.00 175.46 ? 428 LYS A CA    1 
ATOM   3429 C  C     . LYS A 1 428 ? 141.864 145.257 184.308 1.00 175.46 ? 428 LYS A C     1 
ATOM   3430 O  O     . LYS A 1 428 ? 140.948 146.062 184.513 1.00 175.46 ? 428 LYS A O     1 
ATOM   3431 C  CB    . LYS A 1 428 ? 141.069 142.916 183.828 1.00 175.46 ? 428 LYS A CB    1 
ATOM   3432 C  CG    . LYS A 1 428 ? 141.304 142.694 185.312 1.00 175.46 ? 428 LYS A CG    1 
ATOM   3433 C  CD    . LYS A 1 428 ? 140.987 141.262 185.708 1.00 175.46 ? 428 LYS A CD    1 
ATOM   3434 C  CE    . LYS A 1 428 ? 141.422 140.973 187.134 1.00 175.46 ? 428 LYS A CE    1 
ATOM   3435 N  NZ    . LYS A 1 428 ? 142.863 141.265 187.345 1.00 175.46 ? 428 LYS A NZ    1 
ATOM   3436 N  N     . GLU A 1 429 ? 143.018 145.305 184.980 1.00 173.87 ? 429 GLU A N     1 
ATOM   3437 C  CA    . GLU A 1 429 ? 143.258 146.374 185.943 1.00 173.87 ? 429 GLU A CA    1 
ATOM   3438 C  C     . GLU A 1 429 ? 143.309 147.730 185.251 1.00 173.87 ? 429 GLU A C     1 
ATOM   3439 O  O     . GLU A 1 429 ? 142.726 148.707 185.736 1.00 173.87 ? 429 GLU A O     1 
ATOM   3440 C  CB    . GLU A 1 429 ? 144.550 146.103 186.715 1.00 173.87 ? 429 GLU A CB    1 
ATOM   3441 C  CG    . GLU A 1 429 ? 145.154 147.329 187.378 1.00 173.87 ? 429 GLU A CG    1 
ATOM   3442 C  CD    . GLU A 1 429 ? 146.307 147.909 186.585 1.00 173.87 ? 429 GLU A CD    1 
ATOM   3443 O  OE1   . GLU A 1 429 ? 146.677 147.314 185.553 1.00 173.87 ? 429 GLU A OE1   1 
ATOM   3444 O  OE2   . GLU A 1 429 ? 146.845 148.959 186.995 1.00 173.87 ? 429 GLU A OE2   1 
ATOM   3445 N  N     . VAL A 1 430 ? 143.984 147.805 184.103 1.00 169.39 ? 430 VAL A N     1 
ATOM   3446 C  CA    . VAL A 1 430 ? 144.030 149.053 183.347 1.00 169.39 ? 430 VAL A CA    1 
ATOM   3447 C  C     . VAL A 1 430 ? 142.638 149.426 182.851 1.00 169.39 ? 430 VAL A C     1 
ATOM   3448 O  O     . VAL A 1 430 ? 142.244 150.600 182.881 1.00 169.39 ? 430 VAL A O     1 
ATOM   3449 C  CB    . VAL A 1 430 ? 145.036 148.941 182.186 1.00 169.39 ? 430 VAL A CB    1 
ATOM   3450 C  CG1   . VAL A 1 430 ? 144.902 150.128 181.249 1.00 169.39 ? 430 VAL A CG1   1 
ATOM   3451 C  CG2   . VAL A 1 430 ? 146.455 148.849 182.722 1.00 169.39 ? 430 VAL A CG2   1 
ATOM   3452 N  N     . LEU A 1 431 ? 141.872 148.436 182.388 1.00 178.98 ? 431 LEU A N     1 
ATOM   3453 C  CA    . LEU A 1 431 ? 140.528 148.714 181.886 1.00 178.98 ? 431 LEU A CA    1 
ATOM   3454 C  C     . LEU A 1 431 ? 139.627 149.259 182.988 1.00 178.98 ? 431 LEU A C     1 
ATOM   3455 O  O     . LEU A 1 431 ? 138.898 150.238 182.783 1.00 178.98 ? 431 LEU A O     1 
ATOM   3456 C  CB    . LEU A 1 431 ? 139.927 147.453 181.266 1.00 178.98 ? 431 LEU A CB    1 
ATOM   3457 C  CG    . LEU A 1 431 ? 139.926 147.402 179.737 1.00 178.98 ? 431 LEU A CG    1 
ATOM   3458 C  CD1   . LEU A 1 431 ? 138.825 148.286 179.175 1.00 178.98 ? 431 LEU A CD1   1 
ATOM   3459 C  CD2   . LEU A 1 431 ? 141.280 147.807 179.178 1.00 178.98 ? 431 LEU A CD2   1 
ATOM   3460 N  N     . LYS A 1 432 ? 139.663 148.643 184.173 1.00 181.93 ? 432 LYS A N     1 
ATOM   3461 C  CA    . LYS A 1 432 ? 138.843 149.150 185.268 1.00 181.93 ? 432 LYS A CA    1 
ATOM   3462 C  C     . LYS A 1 432 ? 139.337 150.509 185.751 1.00 181.93 ? 432 LYS A C     1 
ATOM   3463 O  O     . LYS A 1 432 ? 138.523 151.359 186.132 1.00 181.93 ? 432 LYS A O     1 
ATOM   3464 C  CB    . LYS A 1 432 ? 138.793 148.142 186.420 1.00 181.93 ? 432 LYS A CB    1 
ATOM   3465 C  CG    . LYS A 1 432 ? 140.116 147.881 187.116 1.00 181.93 ? 432 LYS A CG    1 
ATOM   3466 C  CD    . LYS A 1 432 ? 139.920 147.213 188.470 1.00 181.93 ? 432 LYS A CD    1 
ATOM   3467 C  CE    . LYS A 1 432 ? 138.855 146.128 188.416 1.00 181.93 ? 432 LYS A CE    1 
ATOM   3468 N  NZ    . LYS A 1 432 ? 139.220 145.036 187.470 1.00 181.93 ? 432 LYS A NZ    1 
ATOM   3469 N  N     . LYS A 1 433 ? 140.654 150.741 185.726 1.00 175.36 ? 433 LYS A N     1 
ATOM   3470 C  CA    . LYS A 1 433 ? 141.178 152.062 186.055 1.00 175.36 ? 433 LYS A CA    1 
ATOM   3471 C  C     . LYS A 1 433 ? 140.627 153.117 185.107 1.00 175.36 ? 433 LYS A C     1 
ATOM   3472 O  O     . LYS A 1 433 ? 140.237 154.208 185.536 1.00 175.36 ? 433 LYS A O     1 
ATOM   3473 C  CB    . LYS A 1 433 ? 142.705 152.046 186.000 1.00 175.36 ? 433 LYS A CB    1 
ATOM   3474 C  CG    . LYS A 1 433 ? 143.387 151.906 187.347 1.00 175.36 ? 433 LYS A CG    1 
ATOM   3475 C  CD    . LYS A 1 433 ? 144.845 151.516 187.171 1.00 175.36 ? 433 LYS A CD    1 
ATOM   3476 C  CE    . LYS A 1 433 ? 145.777 152.649 187.563 1.00 175.36 ? 433 LYS A CE    1 
ATOM   3477 N  NZ    . LYS A 1 433 ? 147.129 152.481 186.962 1.00 175.36 ? 433 LYS A NZ    1 
ATOM   3478 N  N     . PHE A 1 434 ? 140.590 152.805 183.810 1.00 181.24 ? 434 PHE A N     1 
ATOM   3479 C  CA    . PHE A 1 434 ? 139.996 153.727 182.850 1.00 181.24 ? 434 PHE A CA    1 
ATOM   3480 C  C     . PHE A 1 434 ? 138.512 153.928 183.123 1.00 181.24 ? 434 PHE A C     1 
ATOM   3481 O  O     . PHE A 1 434 ? 137.999 155.049 183.019 1.00 181.24 ? 434 PHE A O     1 
ATOM   3482 C  CB    . PHE A 1 434 ? 140.209 153.220 181.426 1.00 181.24 ? 434 PHE A CB    1 
ATOM   3483 C  CG    . PHE A 1 434 ? 139.896 154.239 180.375 1.00 181.24 ? 434 PHE A CG    1 
ATOM   3484 C  CD1   . PHE A 1 434 ? 140.254 155.564 180.554 1.00 181.24 ? 434 PHE A CD1   1 
ATOM   3485 C  CD2   . PHE A 1 434 ? 139.232 153.880 179.215 1.00 181.24 ? 434 PHE A CD2   1 
ATOM   3486 C  CE1   . PHE A 1 434 ? 139.965 156.509 179.593 1.00 181.24 ? 434 PHE A CE1   1 
ATOM   3487 C  CE2   . PHE A 1 434 ? 138.941 154.824 178.251 1.00 181.24 ? 434 PHE A CE2   1 
ATOM   3488 C  CZ    . PHE A 1 434 ? 139.307 156.139 178.442 1.00 181.24 ? 434 PHE A CZ    1 
ATOM   3489 N  N     . ARG A 1 435 ? 137.803 152.849 183.464 1.00 182.51 ? 435 ARG A N     1 
ATOM   3490 C  CA    . ARG A 1 435 ? 136.367 152.956 183.706 1.00 182.51 ? 435 ARG A CA    1 
ATOM   3491 C  C     . ARG A 1 435 ? 136.066 153.858 184.897 1.00 182.51 ? 435 ARG A C     1 
ATOM   3492 O  O     . ARG A 1 435 ? 135.119 154.653 184.856 1.00 182.51 ? 435 ARG A O     1 
ATOM   3493 C  CB    . ARG A 1 435 ? 135.760 151.568 183.914 1.00 182.51 ? 435 ARG A CB    1 
ATOM   3494 C  CG    . ARG A 1 435 ? 134.327 151.592 184.424 1.00 182.51 ? 435 ARG A CG    1 
ATOM   3495 C  CD    . ARG A 1 435 ? 133.551 150.362 183.984 1.00 182.51 ? 435 ARG A CD    1 
ATOM   3496 N  NE    . ARG A 1 435 ? 133.043 150.499 182.624 1.00 182.51 ? 435 ARG A NE    1 
ATOM   3497 C  CZ    . ARG A 1 435 ? 133.463 149.782 181.590 1.00 182.51 ? 435 ARG A CZ    1 
ATOM   3498 N  NH1   . ARG A 1 435 ? 134.405 148.864 181.724 1.00 182.51 ? 435 ARG A NH1   1 
ATOM   3499 N  NH2   . ARG A 1 435 ? 132.922 149.992 180.394 1.00 182.51 ? 435 ARG A NH2   1 
ATOM   3500 N  N     . LYS A 1 436 ? 136.858 153.755 185.969 1.00 178.54 ? 436 LYS A N     1 
ATOM   3501 C  CA    . LYS A 1 436 ? 136.639 154.628 187.120 1.00 178.54 ? 436 LYS A CA    1 
ATOM   3502 C  C     . LYS A 1 436 ? 136.842 156.095 186.763 1.00 178.54 ? 436 LYS A C     1 
ATOM   3503 O  O     . LYS A 1 436 ? 136.269 156.976 187.414 1.00 178.54 ? 436 LYS A O     1 
ATOM   3504 C  CB    . LYS A 1 436 ? 137.562 154.245 188.277 1.00 178.54 ? 436 LYS A CB    1 
ATOM   3505 C  CG    . LYS A 1 436 ? 137.517 152.785 188.679 1.00 178.54 ? 436 LYS A CG    1 
ATOM   3506 C  CD    . LYS A 1 436 ? 138.861 152.343 189.232 1.00 178.54 ? 436 LYS A CD    1 
ATOM   3507 C  CE    . LYS A 1 436 ? 138.967 150.829 189.304 1.00 178.54 ? 436 LYS A CE    1 
ATOM   3508 N  NZ    . LYS A 1 436 ? 140.387 150.386 189.377 1.00 178.54 ? 436 LYS A NZ    1 
ATOM   3509 N  N     . GLY A 1 437 ? 137.644 156.377 185.742 1.00 171.77 ? 437 GLY A N     1 
ATOM   3510 C  CA    . GLY A 1 437 ? 137.898 157.736 185.321 1.00 171.77 ? 437 GLY A CA    1 
ATOM   3511 C  C     . GLY A 1 437 ? 139.185 158.348 185.823 1.00 171.77 ? 437 GLY A C     1 
ATOM   3512 O  O     . GLY A 1 437 ? 139.402 159.546 185.608 1.00 171.77 ? 437 GLY A O     1 
ATOM   3513 N  N     . GLU A 1 438 ? 140.044 157.572 186.488 1.00 179.54 ? 438 GLU A N     1 
ATOM   3514 C  CA    . GLU A 1 438 ? 141.323 158.101 186.944 1.00 179.54 ? 438 GLU A CA    1 
ATOM   3515 C  C     . GLU A 1 438 ? 142.250 158.445 185.786 1.00 179.54 ? 438 GLU A C     1 
ATOM   3516 O  O     . GLU A 1 438 ? 143.180 159.238 185.967 1.00 179.54 ? 438 GLU A O     1 
ATOM   3517 C  CB    . GLU A 1 438 ? 142.000 157.103 187.888 1.00 179.54 ? 438 GLU A CB    1 
ATOM   3518 C  CG    . GLU A 1 438 ? 142.420 155.796 187.234 1.00 179.54 ? 438 GLU A CG    1 
ATOM   3519 C  CD    . GLU A 1 438 ? 143.828 155.842 186.677 1.00 179.54 ? 438 GLU A CD    1 
ATOM   3520 O  OE1   . GLU A 1 438 ? 144.593 156.748 187.066 1.00 179.54 ? 438 GLU A OE1   1 
ATOM   3521 O  OE2   . GLU A 1 438 ? 144.168 154.974 185.845 1.00 179.54 ? 438 GLU A OE2   1 
ATOM   3522 N  N     . CYS A 1 439 ? 142.023 157.866 184.610 1.00 179.12 ? 439 CYS A N     1 
ATOM   3523 C  CA    . CYS A 1 439 ? 142.792 158.166 183.411 1.00 179.12 ? 439 CYS A CA    1 
ATOM   3524 C  C     . CYS A 1 439 ? 141.860 158.763 182.368 1.00 179.12 ? 439 CYS A C     1 
ATOM   3525 O  O     . CYS A 1 439 ? 140.769 158.236 182.133 1.00 179.12 ? 439 CYS A O     1 
ATOM   3526 C  CB    . CYS A 1 439 ? 143.473 156.910 182.864 1.00 179.12 ? 439 CYS A CB    1 
ATOM   3527 S  SG    . CYS A 1 439 ? 144.644 157.222 181.525 1.00 179.12 ? 439 CYS A SG    1 
ATOM   3528 N  N     . ASN A 1 440 ? 142.286 159.863 181.749 1.00 171.09 ? 440 ASN A N     1 
ATOM   3529 C  CA    . ASN A 1 440 ? 141.456 160.565 180.779 1.00 171.09 ? 440 ASN A CA    1 
ATOM   3530 C  C     . ASN A 1 440 ? 141.829 160.268 179.335 1.00 171.09 ? 440 ASN A C     1 
ATOM   3531 O  O     . ASN A 1 440 ? 140.937 160.157 178.488 1.00 171.09 ? 440 ASN A O     1 
ATOM   3532 C  CB    . ASN A 1 440 ? 141.533 162.077 181.011 1.00 171.09 ? 440 ASN A CB    1 
ATOM   3533 C  CG    . ASN A 1 440 ? 142.941 162.551 181.290 1.00 171.09 ? 440 ASN A CG    1 
ATOM   3534 O  OD1   . ASN A 1 440 ? 143.898 161.788 181.177 1.00 171.09 ? 440 ASN A OD1   1 
ATOM   3535 N  ND2   . ASN A 1 440 ? 143.076 163.819 181.659 1.00 171.09 ? 440 ASN A ND2   1 
ATOM   3536 N  N     . LEU A 1 441 ? 143.115 160.137 179.033 1.00 171.62 ? 441 LEU A N     1 
ATOM   3537 C  CA    . LEU A 1 441 ? 143.586 159.886 177.678 1.00 171.62 ? 441 LEU A CA    1 
ATOM   3538 C  C     . LEU A 1 441 ? 144.093 158.455 177.578 1.00 171.62 ? 441 LEU A C     1 
ATOM   3539 O  O     . LEU A 1 441 ? 144.840 157.996 178.448 1.00 171.62 ? 441 LEU A O     1 
ATOM   3540 C  CB    . LEU A 1 441 ? 144.694 160.866 177.291 1.00 171.62 ? 441 LEU A CB    1 
ATOM   3541 C  CG    . LEU A 1 441 ? 144.946 161.035 175.792 1.00 171.62 ? 441 LEU A CG    1 
ATOM   3542 C  CD1   . LEU A 1 441 ? 143.662 160.839 175.003 1.00 171.62 ? 441 LEU A CD1   1 
ATOM   3543 C  CD2   . LEU A 1 441 ? 145.552 162.395 175.500 1.00 171.62 ? 441 LEU A CD2   1 
ATOM   3544 N  N     . LEU A 1 442 ? 143.688 157.757 176.521 1.00 167.47 ? 442 LEU A N     1 
ATOM   3545 C  CA    . LEU A 1 442 ? 144.087 156.374 176.303 1.00 167.47 ? 442 LEU A CA    1 
ATOM   3546 C  C     . LEU A 1 442 ? 144.629 156.218 174.891 1.00 167.47 ? 442 LEU A C     1 
ATOM   3547 O  O     . LEU A 1 442 ? 144.020 156.701 173.931 1.00 167.47 ? 442 LEU A O     1 
ATOM   3548 C  CB    . LEU A 1 442 ? 142.912 155.418 176.526 1.00 167.47 ? 442 LEU A CB    1 
ATOM   3549 C  CG    . LEU A 1 442 ? 143.152 153.957 176.142 1.00 167.47 ? 442 LEU A CG    1 
ATOM   3550 C  CD1   . LEU A 1 442 ? 144.290 153.369 176.960 1.00 167.47 ? 442 LEU A CD1   1 
ATOM   3551 C  CD2   . LEU A 1 442 ? 141.885 153.136 176.312 1.00 167.47 ? 442 LEU A CD2   1 
ATOM   3552 N  N     . VAL A 1 443 ? 145.772 155.550 174.772 1.00 146.30 ? 443 VAL A N     1 
ATOM   3553 C  CA    . VAL A 1 443 ? 146.361 155.192 173.487 1.00 146.30 ? 443 VAL A CA    1 
ATOM   3554 C  C     . VAL A 1 443 ? 146.218 153.687 173.330 1.00 146.30 ? 443 VAL A C     1 
ATOM   3555 O  O     . VAL A 1 443 ? 146.700 152.922 174.175 1.00 146.30 ? 443 VAL A O     1 
ATOM   3556 C  CB    . VAL A 1 443 ? 147.833 155.623 173.398 1.00 146.30 ? 443 VAL A CB    1 
ATOM   3557 C  CG1   . VAL A 1 443 ? 148.342 155.473 171.975 1.00 146.30 ? 443 VAL A CG1   1 
ATOM   3558 C  CG2   . VAL A 1 443 ? 147.997 157.053 173.885 1.00 146.30 ? 443 VAL A CG2   1 
ATOM   3559 N  N     . ALA A 1 444 ? 145.560 153.257 172.258 1.00 173.35 ? 444 ALA A N     1 
ATOM   3560 C  CA    . ALA A 1 444 ? 145.229 151.851 172.096 1.00 173.35 ? 444 ALA A CA    1 
ATOM   3561 C  C     . ALA A 1 444 ? 145.266 151.465 170.625 1.00 173.35 ? 444 ALA A C     1 
ATOM   3562 O  O     . ALA A 1 444 ? 145.098 152.299 169.733 1.00 173.35 ? 444 ALA A O     1 
ATOM   3563 C  CB    . ALA A 1 444 ? 143.850 151.529 172.684 1.00 173.35 ? 444 ALA A CB    1 
ATOM   3564 N  N     . THR A 1 445 ? 145.492 150.176 170.389 1.00 150.00 ? 445 THR A N     1 
ATOM   3565 C  CA    . THR A 1 445 ? 145.438 149.596 169.058 1.00 150.00 ? 445 THR A CA    1 
ATOM   3566 C  C     . THR A 1 445 ? 144.032 149.055 168.801 1.00 150.00 ? 445 THR A C     1 
ATOM   3567 O  O     . THR A 1 445 ? 143.083 149.354 169.531 1.00 150.00 ? 445 THR A O     1 
ATOM   3568 C  CB    . THR A 1 445 ? 146.508 148.517 168.901 1.00 150.00 ? 445 THR A CB    1 
ATOM   3569 O  OG1   . THR A 1 445 ? 146.242 147.746 167.724 1.00 150.00 ? 445 THR A OG1   1 
ATOM   3570 C  CG2   . THR A 1 445 ? 146.528 147.603 170.113 1.00 150.00 ? 445 THR A CG2   1 
ATOM   3571 N  N     . SER A 1 446 ? 143.883 148.246 167.752 1.00 141.64 ? 446 SER A N     1 
ATOM   3572 C  CA    . SER A 1 446 ? 142.574 147.763 167.324 1.00 141.64 ? 446 SER A CA    1 
ATOM   3573 C  C     . SER A 1 446 ? 141.956 146.739 168.271 1.00 141.64 ? 446 SER A C     1 
ATOM   3574 O  O     . SER A 1 446 ? 140.886 146.210 167.952 1.00 141.64 ? 446 SER A O     1 
ATOM   3575 C  CB    . SER A 1 446 ? 142.680 147.162 165.922 1.00 141.64 ? 446 SER A CB    1 
ATOM   3576 O  OG    . SER A 1 446 ? 143.543 147.934 165.104 1.00 141.64 ? 446 SER A OG    1 
ATOM   3577 N  N     . VAL A 1 447 ? 142.588 146.437 169.406 1.00 132.70 ? 447 VAL A N     1 
ATOM   3578 C  CA    . VAL A 1 447 ? 142.021 145.461 170.332 1.00 132.70 ? 447 VAL A CA    1 
ATOM   3579 C  C     . VAL A 1 447 ? 140.716 145.977 170.930 1.00 132.70 ? 447 VAL A C     1 
ATOM   3580 O  O     . VAL A 1 447 ? 139.729 145.238 171.033 1.00 132.70 ? 447 VAL A O     1 
ATOM   3581 C  CB    . VAL A 1 447 ? 143.045 145.103 171.425 1.00 132.70 ? 447 VAL A CB    1 
ATOM   3582 C  CG1   . VAL A 1 447 ? 143.688 146.359 171.991 1.00 132.70 ? 447 VAL A CG1   1 
ATOM   3583 C  CG2   . VAL A 1 447 ? 142.388 144.291 172.529 1.00 132.70 ? 447 VAL A CG2   1 
ATOM   3584 N  N     . VAL A 1 448 ? 140.683 147.250 171.321 1.00 130.22 ? 448 VAL A N     1 
ATOM   3585 C  CA    . VAL A 1 448 ? 139.541 147.831 172.019 1.00 130.22 ? 448 VAL A CA    1 
ATOM   3586 C  C     . VAL A 1 448 ? 138.655 148.532 170.994 1.00 130.22 ? 448 VAL A C     1 
ATOM   3587 O  O     . VAL A 1 448 ? 137.506 148.894 171.277 1.00 130.22 ? 448 VAL A O     1 
ATOM   3588 C  CB    . VAL A 1 448 ? 140.038 148.769 173.143 1.00 130.22 ? 448 VAL A CB    1 
ATOM   3589 C  CG1   . VAL A 1 448 ? 139.024 149.841 173.518 1.00 130.22 ? 448 VAL A CG1   1 
ATOM   3590 C  CG2   . VAL A 1 448 ? 140.420 147.955 174.370 1.00 130.22 ? 448 VAL A CG2   1 
ATOM   3591 N  N     . GLU A 1 449 ? 139.157 148.661 169.766 1.00 165.79 ? 449 GLU A N     1 
ATOM   3592 C  CA    . GLU A 1 449 ? 138.410 149.354 168.724 1.00 165.79 ? 449 GLU A CA    1 
ATOM   3593 C  C     . GLU A 1 449 ? 137.067 148.696 168.424 1.00 165.79 ? 449 GLU A C     1 
ATOM   3594 O  O     . GLU A 1 449 ? 136.118 149.391 168.041 1.00 165.79 ? 449 GLU A O     1 
ATOM   3595 C  CB    . GLU A 1 449 ? 139.242 149.425 167.443 1.00 165.79 ? 449 GLU A CB    1 
ATOM   3596 C  CG    . GLU A 1 449 ? 138.617 150.267 166.344 1.00 165.79 ? 449 GLU A CG    1 
ATOM   3597 C  CD    . GLU A 1 449 ? 138.773 149.646 164.972 1.00 165.79 ? 449 GLU A CD    1 
ATOM   3598 O  OE1   . GLU A 1 449 ? 139.020 148.423 164.899 1.00 165.79 ? 449 GLU A OE1   1 
ATOM   3599 O  OE2   . GLU A 1 449 ? 138.646 150.376 163.967 1.00 165.79 ? 449 GLU A OE2   1 
ATOM   3600 N  N     . GLU A 1 450 ? 136.953 147.382 168.601 1.00 201.83 ? 450 GLU A N     1 
ATOM   3601 C  CA    . GLU A 1 450 ? 135.791 146.631 168.130 1.00 201.83 ? 450 GLU A CA    1 
ATOM   3602 C  C     . GLU A 1 450 ? 134.858 146.297 169.290 1.00 201.83 ? 450 GLU A C     1 
ATOM   3603 O  O     . GLU A 1 450 ? 135.199 145.489 170.161 1.00 201.83 ? 450 GLU A O     1 
ATOM   3604 C  CB    . GLU A 1 450 ? 136.230 145.359 167.410 1.00 201.83 ? 450 GLU A CB    1 
ATOM   3605 C  CG    . GLU A 1 450 ? 137.354 145.563 166.410 1.00 201.83 ? 450 GLU A CG    1 
ATOM   3606 C  CD    . GLU A 1 450 ? 137.024 144.995 165.043 1.00 201.83 ? 450 GLU A CD    1 
ATOM   3607 O  OE1   . GLU A 1 450 ? 135.912 144.450 164.876 1.00 201.83 ? 450 GLU A OE1   1 
ATOM   3608 O  OE2   . GLU A 1 450 ? 137.875 145.093 164.134 1.00 201.83 ? 450 GLU A OE2   1 
ATOM   3609 N  N     . GLY A 1 451 ? 133.685 146.924 169.297 1.00 181.32 ? 451 GLY A N     1 
ATOM   3610 C  CA    . GLY A 1 451 ? 132.536 146.436 170.036 1.00 181.32 ? 451 GLY A CA    1 
ATOM   3611 C  C     . GLY A 1 451 ? 132.520 146.599 171.542 1.00 181.32 ? 451 GLY A C     1 
ATOM   3612 O  O     . GLY A 1 451 ? 131.441 146.644 172.139 1.00 181.32 ? 451 GLY A O     1 
ATOM   3613 N  N     . ILE A 1 452 ? 133.688 146.693 172.177 1.00 173.49 ? 452 ILE A N     1 
ATOM   3614 C  CA    . ILE A 1 452 ? 133.726 146.762 173.633 1.00 173.49 ? 452 ILE A CA    1 
ATOM   3615 C  C     . ILE A 1 452 ? 133.247 148.132 174.090 1.00 173.49 ? 452 ILE A C     1 
ATOM   3616 O  O     . ILE A 1 452 ? 133.719 149.168 173.604 1.00 173.49 ? 452 ILE A O     1 
ATOM   3617 C  CB    . ILE A 1 452 ? 135.136 146.452 174.157 1.00 173.49 ? 452 ILE A CB    1 
ATOM   3618 C  CG1   . ILE A 1 452 ? 135.379 147.151 175.498 1.00 173.49 ? 452 ILE A CG1   1 
ATOM   3619 C  CG2   . ILE A 1 452 ? 136.180 146.835 173.136 1.00 173.49 ? 452 ILE A CG2   1 
ATOM   3620 C  CD1   . ILE A 1 452 ? 136.785 146.992 176.027 1.00 173.49 ? 452 ILE A CD1   1 
ATOM   3621 N  N     . ASP A 1 453 ? 132.297 148.138 175.020 1.00 173.04 ? 453 ASP A N     1 
ATOM   3622 C  CA    . ASP A 1 453 ? 131.763 149.387 175.543 1.00 173.04 ? 453 ASP A CA    1 
ATOM   3623 C  C     . ASP A 1 453 ? 132.847 150.164 176.278 1.00 173.04 ? 453 ASP A C     1 
ATOM   3624 O  O     . ASP A 1 453 ? 133.727 149.591 176.928 1.00 173.04 ? 453 ASP A O     1 
ATOM   3625 C  CB    . ASP A 1 453 ? 130.586 149.112 176.480 1.00 173.04 ? 453 ASP A CB    1 
ATOM   3626 C  CG    . ASP A 1 453 ? 130.066 150.369 177.147 1.00 173.04 ? 453 ASP A CG    1 
ATOM   3627 O  OD1   . ASP A 1 453 ? 129.577 151.266 176.427 1.00 173.04 ? 453 ASP A OD1   1 
ATOM   3628 O  OD2   . ASP A 1 453 ? 130.148 150.461 178.390 1.00 173.04 ? 453 ASP A OD2   1 
ATOM   3629 N  N     . ILE A 1 454 ? 132.778 151.486 176.168 1.00 153.02 ? 454 ILE A N     1 
ATOM   3630 C  CA    . ILE A 1 454 ? 133.746 152.371 176.807 1.00 153.02 ? 454 ILE A CA    1 
ATOM   3631 C  C     . ILE A 1 454 ? 132.970 153.367 177.662 1.00 153.02 ? 454 ILE A C     1 
ATOM   3632 O  O     . ILE A 1 454 ? 131.817 153.689 177.338 1.00 153.02 ? 454 ILE A O     1 
ATOM   3633 C  CB    . ILE A 1 454 ? 134.628 153.069 175.756 1.00 153.02 ? 454 ILE A CB    1 
ATOM   3634 C  CG1   . ILE A 1 454 ? 135.961 153.510 176.365 1.00 153.02 ? 454 ILE A CG1   1 
ATOM   3635 C  CG2   . ILE A 1 454 ? 133.900 154.247 175.121 1.00 153.02 ? 454 ILE A CG2   1 
ATOM   3636 C  CD1   . ILE A 1 454 ? 136.834 152.357 176.805 1.00 153.02 ? 454 ILE A CD1   1 
ATOM   3637 N  N     . PRO A 1 455 ? 133.529 153.843 178.774 1.00 180.66 ? 455 PRO A N     1 
ATOM   3638 C  CA    . PRO A 1 455 ? 132.855 154.894 179.543 1.00 180.66 ? 455 PRO A CA    1 
ATOM   3639 C  C     . PRO A 1 455 ? 132.634 156.151 178.712 1.00 180.66 ? 455 PRO A C     1 
ATOM   3640 O  O     . PRO A 1 455 ? 133.130 156.285 177.590 1.00 180.66 ? 455 PRO A O     1 
ATOM   3641 C  CB    . PRO A 1 455 ? 133.815 155.161 180.713 1.00 180.66 ? 455 PRO A CB    1 
ATOM   3642 C  CG    . PRO A 1 455 ? 135.047 154.329 180.440 1.00 180.66 ? 455 PRO A CG    1 
ATOM   3643 C  CD    . PRO A 1 455 ? 134.617 153.224 179.543 1.00 180.66 ? 455 PRO A CD    1 
ATOM   3644 N  N     . LYS A 1 456 ? 131.865 157.077 179.283 1.00 199.12 ? 456 LYS A N     1 
ATOM   3645 C  CA    . LYS A 1 456 ? 131.502 158.309 178.591 1.00 199.12 ? 456 LYS A CA    1 
ATOM   3646 C  C     . LYS A 1 456 ? 132.738 159.055 178.117 1.00 199.12 ? 456 LYS A C     1 
ATOM   3647 O  O     . LYS A 1 456 ? 133.549 159.515 178.925 1.00 199.12 ? 456 LYS A O     1 
ATOM   3648 C  CB    . LYS A 1 456 ? 130.667 159.197 179.515 1.00 199.12 ? 456 LYS A CB    1 
ATOM   3649 C  CG    . LYS A 1 456 ? 129.364 158.564 179.966 1.00 199.12 ? 456 LYS A CG    1 
ATOM   3650 C  CD    . LYS A 1 456 ? 128.450 159.591 180.607 1.00 199.12 ? 456 LYS A CD    1 
ATOM   3651 C  CE    . LYS A 1 456 ? 127.989 160.622 179.591 1.00 199.12 ? 456 LYS A CE    1 
ATOM   3652 N  NZ    . LYS A 1 456 ? 127.234 159.995 178.471 1.00 199.12 ? 456 LYS A NZ    1 
ATOM   3653 N  N     . CYS A 1 457 ? 132.876 159.173 176.799 1.00 185.07 ? 457 CYS A N     1 
ATOM   3654 C  CA    . CYS A 1 457 ? 134.031 159.798 176.173 1.00 185.07 ? 457 CYS A CA    1 
ATOM   3655 C  C     . CYS A 1 457 ? 133.571 160.974 175.326 1.00 185.07 ? 457 CYS A C     1 
ATOM   3656 O  O     . CYS A 1 457 ? 132.539 160.892 174.650 1.00 185.07 ? 457 CYS A O     1 
ATOM   3657 C  CB    . CYS A 1 457 ? 134.801 158.791 175.316 1.00 185.07 ? 457 CYS A CB    1 
ATOM   3658 S  SG    . CYS A 1 457 ? 133.760 157.794 174.230 1.00 185.07 ? 457 CYS A SG    1 
ATOM   3659 N  N     . ASN A 1 458 ? 134.335 162.064 175.367 1.00 158.30 ? 458 ASN A N     1 
ATOM   3660 C  CA    . ASN A 1 458 ? 133.981 163.274 174.635 1.00 158.30 ? 458 ASN A CA    1 
ATOM   3661 C  C     . ASN A 1 458 ? 134.773 163.445 173.348 1.00 158.30 ? 458 ASN A C     1 
ATOM   3662 O  O     . ASN A 1 458 ? 134.284 164.089 172.412 1.00 158.30 ? 458 ASN A O     1 
ATOM   3663 C  CB    . ASN A 1 458 ? 134.194 164.503 175.521 1.00 158.30 ? 458 ASN A CB    1 
ATOM   3664 C  CG    . ASN A 1 458 ? 133.499 164.381 176.859 1.00 158.30 ? 458 ASN A CG    1 
ATOM   3665 O  OD1   . ASN A 1 458 ? 134.086 164.662 177.904 1.00 158.30 ? 458 ASN A OD1   1 
ATOM   3666 N  ND2   . ASN A 1 458 ? 132.242 163.959 176.836 1.00 158.30 ? 458 ASN A ND2   1 
ATOM   3667 N  N     . LEU A 1 459 ? 135.980 162.889 173.272 1.00 136.30 ? 459 LEU A N     1 
ATOM   3668 C  CA    . LEU A 1 459 ? 136.865 163.106 172.137 1.00 136.30 ? 459 LEU A CA    1 
ATOM   3669 C  C     . LEU A 1 459 ? 137.445 161.788 171.649 1.00 136.30 ? 459 LEU A C     1 
ATOM   3670 O  O     . LEU A 1 459 ? 137.891 160.959 172.448 1.00 136.30 ? 459 LEU A O     1 
ATOM   3671 C  CB    . LEU A 1 459 ? 138.002 164.068 172.505 1.00 136.30 ? 459 LEU A CB    1 
ATOM   3672 C  CG    . LEU A 1 459 ? 139.104 164.279 171.464 1.00 136.30 ? 459 LEU A CG    1 
ATOM   3673 C  CD1   . LEU A 1 459 ? 138.531 164.851 170.179 1.00 136.30 ? 459 LEU A CD1   1 
ATOM   3674 C  CD2   . LEU A 1 459 ? 140.190 165.185 172.015 1.00 136.30 ? 459 LEU A CD2   1 
ATOM   3675 N  N     . VAL A 1 460 ? 137.430 161.603 170.331 1.00 154.72 ? 460 VAL A N     1 
ATOM   3676 C  CA    . VAL A 1 460 ? 138.102 160.494 169.666 1.00 154.72 ? 460 VAL A CA    1 
ATOM   3677 C  C     . VAL A 1 460 ? 138.941 161.071 168.535 1.00 154.72 ? 460 VAL A C     1 
ATOM   3678 O  O     . VAL A 1 460 ? 138.417 161.787 167.674 1.00 154.72 ? 460 VAL A O     1 
ATOM   3679 C  CB    . VAL A 1 460 ? 137.100 159.456 169.126 1.00 154.72 ? 460 VAL A CB    1 
ATOM   3680 C  CG1   . VAL A 1 460 ? 137.770 158.546 168.110 1.00 154.72 ? 460 VAL A CG1   1 
ATOM   3681 C  CG2   . VAL A 1 460 ? 136.524 158.641 170.269 1.00 154.72 ? 460 VAL A CG2   1 
ATOM   3682 N  N     . VAL A 1 461 ? 140.236 160.764 168.535 1.00 136.72 ? 461 VAL A N     1 
ATOM   3683 C  CA    . VAL A 1 461 ? 141.177 161.302 167.560 1.00 136.72 ? 461 VAL A CA    1 
ATOM   3684 C  C     . VAL A 1 461 ? 141.877 160.143 166.863 1.00 136.72 ? 461 VAL A C     1 
ATOM   3685 O  O     . VAL A 1 461 ? 142.342 159.204 167.520 1.00 136.72 ? 461 VAL A O     1 
ATOM   3686 C  CB    . VAL A 1 461 ? 142.199 162.248 168.215 1.00 136.72 ? 461 VAL A CB    1 
ATOM   3687 C  CG1   . VAL A 1 461 ? 141.564 163.601 168.481 1.00 136.72 ? 461 VAL A CG1   1 
ATOM   3688 C  CG2   . VAL A 1 461 ? 142.731 161.650 169.506 1.00 136.72 ? 461 VAL A CG2   1 
ATOM   3689 N  N     . ARG A 1 462 ? 141.942 160.210 165.535 1.00 142.10 ? 462 ARG A N     1 
ATOM   3690 C  CA    . ARG A 1 462 ? 142.557 159.168 164.716 1.00 142.10 ? 462 ARG A CA    1 
ATOM   3691 C  C     . ARG A 1 462 ? 143.953 159.628 164.311 1.00 142.10 ? 462 ARG A C     1 
ATOM   3692 O  O     . ARG A 1 462 ? 144.105 160.511 163.464 1.00 142.10 ? 462 ARG A O     1 
ATOM   3693 C  CB    . ARG A 1 462 ? 141.698 158.867 163.493 1.00 142.10 ? 462 ARG A CB    1 
ATOM   3694 C  CG    . ARG A 1 462 ? 140.432 158.090 163.794 1.00 142.10 ? 462 ARG A CG    1 
ATOM   3695 C  CD    . ARG A 1 462 ? 140.741 156.636 164.099 1.00 142.10 ? 462 ARG A CD    1 
ATOM   3696 N  NE    . ARG A 1 462 ? 141.188 155.914 162.914 1.00 142.10 ? 462 ARG A NE    1 
ATOM   3697 C  CZ    . ARG A 1 462 ? 141.745 154.713 162.936 1.00 142.10 ? 462 ARG A CZ    1 
ATOM   3698 N  NH1   . ARG A 1 462 ? 141.941 154.062 164.071 1.00 142.10 ? 462 ARG A NH1   1 
ATOM   3699 N  NH2   . ARG A 1 462 ? 142.116 154.148 161.791 1.00 142.10 ? 462 ARG A NH2   1 
ATOM   3700 N  N     . PHE A 1 463 ? 144.975 159.026 164.924 1.00 155.88 ? 463 PHE A N     1 
ATOM   3701 C  CA    . PHE A 1 463 ? 146.346 159.297 164.505 1.00 155.88 ? 463 PHE A CA    1 
ATOM   3702 C  C     . PHE A 1 463 ? 146.574 158.836 163.071 1.00 155.88 ? 463 PHE A C     1 
ATOM   3703 O  O     . PHE A 1 463 ? 147.196 159.547 162.273 1.00 155.88 ? 463 PHE A O     1 
ATOM   3704 C  CB    . PHE A 1 463 ? 147.325 158.612 165.460 1.00 155.88 ? 463 PHE A CB    1 
ATOM   3705 C  CG    . PHE A 1 463 ? 148.668 159.289 165.563 1.00 155.88 ? 463 PHE A CG    1 
ATOM   3706 C  CD1   . PHE A 1 463 ? 149.300 159.406 166.790 1.00 155.88 ? 463 PHE A CD1   1 
ATOM   3707 C  CD2   . PHE A 1 463 ? 149.308 159.790 164.442 1.00 155.88 ? 463 PHE A CD2   1 
ATOM   3708 C  CE1   . PHE A 1 463 ? 150.534 160.020 166.897 1.00 155.88 ? 463 PHE A CE1   1 
ATOM   3709 C  CE2   . PHE A 1 463 ? 150.541 160.401 164.543 1.00 155.88 ? 463 PHE A CE2   1 
ATOM   3710 C  CZ    . PHE A 1 463 ? 151.154 160.518 165.772 1.00 155.88 ? 463 PHE A CZ    1 
ATOM   3711 N  N     . ASP A 1 464 ? 146.069 157.660 162.722 1.00 168.80 ? 464 ASP A N     1 
ATOM   3712 C  CA    . ASP A 1 464 ? 146.230 157.098 161.393 1.00 168.80 ? 464 ASP A CA    1 
ATOM   3713 C  C     . ASP A 1 464 ? 144.885 157.024 160.684 1.00 168.80 ? 464 ASP A C     1 
ATOM   3714 O  O     . ASP A 1 464 ? 143.823 157.000 161.312 1.00 168.80 ? 464 ASP A O     1 
ATOM   3715 C  CB    . ASP A 1 464 ? 146.868 155.707 161.459 1.00 168.80 ? 464 ASP A CB    1 
ATOM   3716 C  CG    . ASP A 1 464 ? 148.349 155.731 161.139 1.00 168.80 ? 464 ASP A CG    1 
ATOM   3717 O  OD1   . ASP A 1 464 ? 148.890 156.833 160.908 1.00 168.80 ? 464 ASP A OD1   1 
ATOM   3718 O  OD2   . ASP A 1 464 ? 148.974 154.649 161.121 1.00 168.80 ? 464 ASP A OD2   1 
ATOM   3719 N  N     . LEU A 1 465 ? 144.947 156.991 159.356 1.00 210.51 ? 465 LEU A N     1 
ATOM   3720 C  CA    . LEU A 1 465 ? 143.741 156.952 158.547 1.00 210.51 ? 465 LEU A CA    1 
ATOM   3721 C  C     . LEU A 1 465 ? 143.033 155.606 158.698 1.00 210.51 ? 465 LEU A C     1 
ATOM   3722 O  O     . LEU A 1 465 ? 143.675 154.577 158.924 1.00 210.51 ? 465 LEU A O     1 
ATOM   3723 C  CB    . LEU A 1 465 ? 144.076 157.195 157.078 1.00 210.51 ? 465 LEU A CB    1 
ATOM   3724 C  CG    . LEU A 1 465 ? 144.129 158.648 156.600 1.00 210.51 ? 465 LEU A CG    1 
ATOM   3725 C  CD1   . LEU A 1 465 ? 145.365 159.356 157.134 1.00 210.51 ? 465 LEU A CD1   1 
ATOM   3726 C  CD2   . LEU A 1 465 ? 144.085 158.712 155.080 1.00 210.51 ? 465 LEU A CD2   1 
ATOM   3727 N  N     . PRO A 1 466 ? 141.706 155.588 158.580 1.00 185.85 ? 466 PRO A N     1 
ATOM   3728 C  CA    . PRO A 1 466 ? 140.982 154.313 158.624 1.00 185.85 ? 466 PRO A CA    1 
ATOM   3729 C  C     . PRO A 1 466 ? 141.331 153.442 157.428 1.00 185.85 ? 466 PRO A C     1 
ATOM   3730 O  O     . PRO A 1 466 ? 141.736 153.931 156.372 1.00 185.85 ? 466 PRO A O     1 
ATOM   3731 C  CB    . PRO A 1 466 ? 139.509 154.737 158.603 1.00 185.85 ? 466 PRO A CB    1 
ATOM   3732 C  CG    . PRO A 1 466 ? 139.516 156.086 157.968 1.00 185.85 ? 466 PRO A CG    1 
ATOM   3733 C  CD    . PRO A 1 466 ? 140.798 156.734 158.400 1.00 185.85 ? 466 PRO A CD    1 
ATOM   3734 N  N     . LYS A 1 467 ? 141.171 152.130 157.607 1.00 190.58 ? 467 LYS A N     1 
ATOM   3735 C  CA    . LYS A 1 467 ? 141.573 151.167 156.594 1.00 190.58 ? 467 LYS A CA    1 
ATOM   3736 C  C     . LYS A 1 467 ? 140.415 150.582 155.798 1.00 190.58 ? 467 LYS A C     1 
ATOM   3737 O  O     . LYS A 1 467 ? 140.615 150.216 154.635 1.00 190.58 ? 467 LYS A O     1 
ATOM   3738 C  CB    . LYS A 1 467 ? 142.365 150.023 157.243 1.00 190.58 ? 467 LYS A CB    1 
ATOM   3739 C  CG    . LYS A 1 467 ? 143.577 150.499 158.028 1.00 190.58 ? 467 LYS A CG    1 
ATOM   3740 C  CD    . LYS A 1 467 ? 144.879 150.189 157.309 1.00 190.58 ? 467 LYS A CD    1 
ATOM   3741 C  CE    . LYS A 1 467 ? 145.203 148.706 157.362 1.00 190.58 ? 467 LYS A CE    1 
ATOM   3742 N  NZ    . LYS A 1 467 ? 146.612 148.436 156.964 1.00 190.58 ? 467 LYS A NZ    1 
ATOM   3743 N  N     . ASN A 1 468 ? 139.221 150.485 156.379 1.00 173.99 ? 468 ASN A N     1 
ATOM   3744 C  CA    . ASN A 1 468 ? 138.059 149.978 155.662 1.00 173.99 ? 468 ASN A CA    1 
ATOM   3745 C  C     . ASN A 1 468 ? 136.805 150.645 156.213 1.00 173.99 ? 468 ASN A C     1 
ATOM   3746 O  O     . ASN A 1 468 ? 136.862 151.458 157.139 1.00 173.99 ? 468 ASN A O     1 
ATOM   3747 C  CB    . ASN A 1 468 ? 137.978 148.449 155.745 1.00 173.99 ? 468 ASN A CB    1 
ATOM   3748 C  CG    . ASN A 1 468 ? 138.015 147.932 157.172 1.00 173.99 ? 468 ASN A CG    1 
ATOM   3749 O  OD1   . ASN A 1 468 ? 137.494 148.561 158.090 1.00 173.99 ? 468 ASN A OD1   1 
ATOM   3750 N  ND2   . ASN A 1 468 ? 138.632 146.772 157.360 1.00 173.99 ? 468 ASN A ND2   1 
ATOM   3751 N  N     . PHE A 1 469 ? 135.659 150.288 155.627 1.00 176.18 ? 469 PHE A N     1 
ATOM   3752 C  CA    . PHE A 1 469 ? 134.393 150.911 156.005 1.00 176.18 ? 469 PHE A CA    1 
ATOM   3753 C  C     . PHE A 1 469 ? 134.034 150.607 157.455 1.00 176.18 ? 469 PHE A C     1 
ATOM   3754 O  O     . PHE A 1 469 ? 133.651 151.507 158.216 1.00 176.18 ? 469 PHE A O     1 
ATOM   3755 C  CB    . PHE A 1 469 ? 133.287 150.433 155.063 1.00 176.18 ? 469 PHE A CB    1 
ATOM   3756 C  CG    . PHE A 1 469 ? 131.918 150.932 155.425 1.00 176.18 ? 469 PHE A CG    1 
ATOM   3757 C  CD1   . PHE A 1 469 ? 131.554 152.242 155.173 1.00 176.18 ? 469 PHE A CD1   1 
ATOM   3758 C  CD2   . PHE A 1 469 ? 130.990 150.086 156.008 1.00 176.18 ? 469 PHE A CD2   1 
ATOM   3759 C  CE1   . PHE A 1 469 ? 130.293 152.701 155.502 1.00 176.18 ? 469 PHE A CE1   1 
ATOM   3760 C  CE2   . PHE A 1 469 ? 129.729 150.540 156.339 1.00 176.18 ? 469 PHE A CE2   1 
ATOM   3761 C  CZ    . PHE A 1 469 ? 129.379 151.849 156.084 1.00 176.18 ? 469 PHE A CZ    1 
ATOM   3762 N  N     . ARG A 1 470 ? 134.154 149.341 157.859 1.00 168.15 ? 470 ARG A N     1 
ATOM   3763 C  CA    . ARG A 1 470 ? 133.715 148.947 159.193 1.00 168.15 ? 470 ARG A CA    1 
ATOM   3764 C  C     . ARG A 1 470 ? 134.554 149.609 160.278 1.00 168.15 ? 470 ARG A C     1 
ATOM   3765 O  O     . ARG A 1 470 ? 134.027 149.993 161.328 1.00 168.15 ? 470 ARG A O     1 
ATOM   3766 C  CB    . ARG A 1 470 ? 133.741 147.422 159.329 1.00 168.15 ? 470 ARG A CB    1 
ATOM   3767 C  CG    . ARG A 1 470 ? 135.127 146.808 159.367 1.00 168.15 ? 470 ARG A CG    1 
ATOM   3768 C  CD    . ARG A 1 470 ? 135.104 145.419 159.969 1.00 168.15 ? 470 ARG A CD    1 
ATOM   3769 N  NE    . ARG A 1 470 ? 136.422 144.799 159.933 1.00 168.15 ? 470 ARG A NE    1 
ATOM   3770 C  CZ    . ARG A 1 470 ? 137.343 144.944 160.876 1.00 168.15 ? 470 ARG A CZ    1 
ATOM   3771 N  NH1   . ARG A 1 470 ? 137.120 145.683 161.951 1.00 168.15 ? 470 ARG A NH1   1 
ATOM   3772 N  NH2   . ARG A 1 470 ? 138.516 144.335 160.737 1.00 168.15 ? 470 ARG A NH2   1 
ATOM   3773 N  N     . SER A 1 471 ? 135.863 149.752 160.045 1.00 159.50 ? 471 SER A N     1 
ATOM   3774 C  CA    . SER A 1 471 ? 136.712 150.419 161.025 1.00 159.50 ? 471 SER A CA    1 
ATOM   3775 C  C     . SER A 1 471 ? 136.295 151.870 161.206 1.00 159.50 ? 471 SER A C     1 
ATOM   3776 O  O     . SER A 1 471 ? 136.216 152.367 162.335 1.00 159.50 ? 471 SER A O     1 
ATOM   3777 C  CB    . SER A 1 471 ? 138.177 150.328 160.604 1.00 159.50 ? 471 SER A CB    1 
ATOM   3778 O  OG    . SER A 1 471 ? 138.978 151.237 161.339 1.00 159.50 ? 471 SER A OG    1 
ATOM   3779 N  N     . TYR A 1 472 ? 136.008 152.559 160.100 1.00 145.60 ? 472 TYR A N     1 
ATOM   3780 C  CA    . TYR A 1 472 ? 135.530 153.936 160.181 1.00 145.60 ? 472 TYR A CA    1 
ATOM   3781 C  C     . TYR A 1 472 ? 134.212 154.016 160.940 1.00 145.60 ? 472 TYR A C     1 
ATOM   3782 O  O     . TYR A 1 472 ? 134.029 154.898 161.790 1.00 145.60 ? 472 TYR A O     1 
ATOM   3783 C  CB    . TYR A 1 472 ? 135.390 154.511 158.771 1.00 145.60 ? 472 TYR A CB    1 
ATOM   3784 C  CG    . TYR A 1 472 ? 134.559 155.769 158.676 1.00 145.60 ? 472 TYR A CG    1 
ATOM   3785 C  CD1   . TYR A 1 472 ? 135.057 156.989 159.105 1.00 145.60 ? 472 TYR A CD1   1 
ATOM   3786 C  CD2   . TYR A 1 472 ? 133.282 155.736 158.133 1.00 145.60 ? 472 TYR A CD2   1 
ATOM   3787 C  CE1   . TYR A 1 472 ? 134.301 158.141 159.010 1.00 145.60 ? 472 TYR A CE1   1 
ATOM   3788 C  CE2   . TYR A 1 472 ? 132.519 156.882 158.033 1.00 145.60 ? 472 TYR A CE2   1 
ATOM   3789 C  CZ    . TYR A 1 472 ? 133.033 158.081 158.474 1.00 145.60 ? 472 TYR A CZ    1 
ATOM   3790 O  OH    . TYR A 1 472 ? 132.276 159.225 158.376 1.00 145.60 ? 472 TYR A OH    1 
ATOM   3791 N  N     . VAL A 1 473 ? 133.292 153.086 160.667 1.00 153.02 ? 473 VAL A N     1 
ATOM   3792 C  CA    . VAL A 1 473 ? 131.988 153.110 161.329 1.00 153.02 ? 473 VAL A CA    1 
ATOM   3793 C  C     . VAL A 1 473 ? 132.143 152.912 162.832 1.00 153.02 ? 473 VAL A C     1 
ATOM   3794 O  O     . VAL A 1 473 ? 131.572 153.659 163.638 1.00 153.02 ? 473 VAL A O     1 
ATOM   3795 C  CB    . VAL A 1 473 ? 131.054 152.053 160.715 1.00 153.02 ? 473 VAL A CB    1 
ATOM   3796 C  CG1   . VAL A 1 473 ? 129.766 151.965 161.512 1.00 153.02 ? 473 VAL A CG1   1 
ATOM   3797 C  CG2   . VAL A 1 473 ? 130.758 152.387 159.268 1.00 153.02 ? 473 VAL A CG2   1 
ATOM   3798 N  N     . GLN A 1 474 ? 132.917 151.902 163.237 1.00 166.31 ? 474 GLN A N     1 
ATOM   3799 C  CA    . GLN A 1 474 ? 133.049 151.629 164.665 1.00 166.31 ? 474 GLN A CA    1 
ATOM   3800 C  C     . GLN A 1 474 ? 133.831 152.725 165.377 1.00 166.31 ? 474 GLN A C     1 
ATOM   3801 O  O     . GLN A 1 474 ? 133.523 153.049 166.528 1.00 166.31 ? 474 GLN A O     1 
ATOM   3802 C  CB    . GLN A 1 474 ? 133.706 150.270 164.904 1.00 166.31 ? 474 GLN A CB    1 
ATOM   3803 C  CG    . GLN A 1 474 ? 135.022 150.069 164.188 1.00 166.31 ? 474 GLN A CG    1 
ATOM   3804 C  CD    . GLN A 1 474 ? 135.496 148.634 164.243 1.00 166.31 ? 474 GLN A CD    1 
ATOM   3805 O  OE1   . GLN A 1 474 ? 136.017 148.180 165.259 1.00 166.31 ? 474 GLN A OE1   1 
ATOM   3806 N  NE2   . GLN A 1 474 ? 135.313 147.906 163.146 1.00 166.31 ? 474 GLN A NE2   1 
ATOM   3807 N  N     . SER A 1 475 ? 134.838 153.306 164.719 1.00 154.37 ? 475 SER A N     1 
ATOM   3808 C  CA    . SER A 1 475 ? 135.566 154.412 165.327 1.00 154.37 ? 475 SER A CA    1 
ATOM   3809 C  C     . SER A 1 475 ? 134.669 155.631 165.502 1.00 154.37 ? 475 SER A C     1 
ATOM   3810 O  O     . SER A 1 475 ? 134.763 156.336 166.514 1.00 154.37 ? 475 SER A O     1 
ATOM   3811 C  CB    . SER A 1 475 ? 136.793 154.754 164.487 1.00 154.37 ? 475 SER A CB    1 
ATOM   3812 O  OG    . SER A 1 475 ? 137.563 153.595 164.227 1.00 154.37 ? 475 SER A OG    1 
ATOM   3813 N  N     . LYS A 1 476 ? 133.794 155.898 164.528 1.00 151.46 ? 476 LYS A N     1 
ATOM   3814 C  CA    . LYS A 1 476 ? 132.811 156.963 164.697 1.00 151.46 ? 476 LYS A CA    1 
ATOM   3815 C  C     . LYS A 1 476 ? 131.870 156.659 165.855 1.00 151.46 ? 476 LYS A C     1 
ATOM   3816 O  O     . LYS A 1 476 ? 131.531 157.551 166.642 1.00 151.46 ? 476 LYS A O     1 
ATOM   3817 C  CB    . LYS A 1 476 ? 132.019 157.160 163.406 1.00 151.46 ? 476 LYS A CB    1 
ATOM   3818 C  CG    . LYS A 1 476 ? 132.652 158.127 162.424 1.00 151.46 ? 476 LYS A CG    1 
ATOM   3819 C  CD    . LYS A 1 476 ? 131.671 159.213 162.019 1.00 151.46 ? 476 LYS A CD    1 
ATOM   3820 C  CE    . LYS A 1 476 ? 130.543 158.645 161.173 1.00 151.46 ? 476 LYS A CE    1 
ATOM   3821 N  NZ    . LYS A 1 476 ? 129.590 159.700 160.734 1.00 151.46 ? 476 LYS A NZ    1 
ATOM   3822 N  N     . GLY A 1 477 ? 131.441 155.405 165.978 1.00 165.44 ? 477 GLY A N     1 
ATOM   3823 C  CA    . GLY A 1 477 ? 130.532 155.020 167.041 1.00 165.44 ? 477 GLY A CA    1 
ATOM   3824 C  C     . GLY A 1 477 ? 131.161 154.838 168.406 1.00 165.44 ? 477 GLY A C     1 
ATOM   3825 O  O     . GLY A 1 477 ? 130.431 154.625 169.378 1.00 165.44 ? 477 GLY A O     1 
ATOM   3826 N  N     . ARG A 1 478 ? 132.492 154.906 168.502 1.00 141.41 ? 478 ARG A N     1 
ATOM   3827 C  CA    . ARG A 1 478 ? 133.147 154.731 169.794 1.00 141.41 ? 478 ARG A CA    1 
ATOM   3828 C  C     . ARG A 1 478 ? 132.720 155.807 170.783 1.00 141.41 ? 478 ARG A C     1 
ATOM   3829 O  O     . ARG A 1 478 ? 132.616 155.548 171.988 1.00 141.41 ? 478 ARG A O     1 
ATOM   3830 C  CB    . ARG A 1 478 ? 134.666 154.737 169.624 1.00 141.41 ? 478 ARG A CB    1 
ATOM   3831 C  CG    . ARG A 1 478 ? 135.254 153.414 169.152 1.00 141.41 ? 478 ARG A CG    1 
ATOM   3832 C  CD    . ARG A 1 478 ? 135.226 152.345 170.242 1.00 141.41 ? 478 ARG A CD    1 
ATOM   3833 N  NE    . ARG A 1 478 ? 133.933 151.681 170.357 1.00 141.41 ? 478 ARG A NE    1 
ATOM   3834 C  CZ    . ARG A 1 478 ? 133.416 150.864 169.449 1.00 141.41 ? 478 ARG A CZ    1 
ATOM   3835 N  NH1   . ARG A 1 478 ? 134.061 150.576 168.330 1.00 141.41 ? 478 ARG A NH1   1 
ATOM   3836 N  NH2   . ARG A 1 478 ? 132.223 150.322 169.669 1.00 141.41 ? 478 ARG A NH2   1 
ATOM   3837 N  N     . ALA A 1 479 ? 132.475 157.019 170.297 1.00 160.76 ? 479 ALA A N     1 
ATOM   3838 C  CA    . ALA A 1 479 ? 132.001 158.096 171.151 1.00 160.76 ? 479 ALA A CA    1 
ATOM   3839 C  C     . ALA A 1 479 ? 130.529 157.885 171.482 1.00 160.76 ? 479 ALA A C     1 
ATOM   3840 O  O     . ALA A 1 479 ? 129.714 157.639 170.589 1.00 160.76 ? 479 ALA A O     1 
ATOM   3841 C  CB    . ALA A 1 479 ? 132.205 159.445 170.468 1.00 160.76 ? 479 ALA A CB    1 
ATOM   3842 N  N     . ARG A 1 480 ? 130.189 157.984 172.767 1.00 178.57 ? 480 ARG A N     1 
ATOM   3843 C  CA    . ARG A 1 480 ? 128.823 157.758 173.219 1.00 178.57 ? 480 ARG A CA    1 
ATOM   3844 C  C     . ARG A 1 480 ? 128.200 158.951 173.928 1.00 178.57 ? 480 ARG A C     1 
ATOM   3845 O  O     . ARG A 1 480 ? 126.977 159.101 173.882 1.00 178.57 ? 480 ARG A O     1 
ATOM   3846 C  CB    . ARG A 1 480 ? 128.757 156.535 174.150 1.00 178.57 ? 480 ARG A CB    1 
ATOM   3847 C  CG    . ARG A 1 480 ? 129.338 156.753 175.540 1.00 178.57 ? 480 ARG A CG    1 
ATOM   3848 C  CD    . ARG A 1 480 ? 129.102 155.538 176.423 1.00 178.57 ? 480 ARG A CD    1 
ATOM   3849 N  NE    . ARG A 1 480 ? 129.409 155.803 177.824 1.00 178.57 ? 480 ARG A NE    1 
ATOM   3850 C  CZ    . ARG A 1 480 ? 129.333 154.896 178.789 1.00 178.57 ? 480 ARG A CZ    1 
ATOM   3851 N  NH1   . ARG A 1 480 ? 128.986 153.646 178.537 1.00 178.57 ? 480 ARG A NH1   1 
ATOM   3852 N  NH2   . ARG A 1 480 ? 129.612 155.255 180.039 1.00 178.57 ? 480 ARG A NH2   1 
ATOM   3853 N  N     . ALA A 1 481 ? 128.994 159.800 174.573 1.00 182.22 ? 481 ALA A N     1 
ATOM   3854 C  CA    . ALA A 1 481 ? 128.443 160.944 175.281 1.00 182.22 ? 481 ALA A CA    1 
ATOM   3855 C  C     . ALA A 1 481 ? 127.985 162.019 174.298 1.00 182.22 ? 481 ALA A C     1 
ATOM   3856 O  O     . ALA A 1 481 ? 128.366 162.033 173.123 1.00 182.22 ? 481 ALA A O     1 
ATOM   3857 C  CB    . ALA A 1 481 ? 129.470 161.522 176.253 1.00 182.22 ? 481 ALA A CB    1 
ATOM   3858 N  N     . LYS A 1 482 ? 127.150 162.925 174.796 1.00 193.10 ? 482 LYS A N     1 
ATOM   3859 C  CA    . LYS A 1 482 ? 126.643 164.015 173.976 1.00 193.10 ? 482 LYS A CA    1 
ATOM   3860 C  C     . LYS A 1 482 ? 127.745 165.037 173.710 1.00 193.10 ? 482 LYS A C     1 
ATOM   3861 O  O     . LYS A 1 482 ? 128.653 165.231 174.524 1.00 193.10 ? 482 LYS A O     1 
ATOM   3862 C  CB    . LYS A 1 482 ? 125.446 164.679 174.660 1.00 193.10 ? 482 LYS A CB    1 
ATOM   3863 C  CG    . LYS A 1 482 ? 124.803 165.815 173.877 1.00 193.10 ? 482 LYS A CG    1 
ATOM   3864 C  CD    . LYS A 1 482 ? 124.379 165.372 172.483 1.00 193.10 ? 482 LYS A CD    1 
ATOM   3865 C  CE    . LYS A 1 482 ? 123.375 164.228 172.533 1.00 193.10 ? 482 LYS A CE    1 
ATOM   3866 N  NZ    . LYS A 1 482 ? 123.193 163.595 171.199 1.00 193.10 ? 482 LYS A NZ    1 
ATOM   3867 N  N     . ASN A 1 483 ? 127.659 165.686 172.546 1.00 178.16 ? 483 ASN A N     1 
ATOM   3868 C  CA    . ASN A 1 483 ? 128.646 166.673 172.102 1.00 178.16 ? 483 ASN A CA    1 
ATOM   3869 C  C     . ASN A 1 483 ? 130.026 166.032 171.957 1.00 178.16 ? 483 ASN A C     1 
ATOM   3870 O  O     . ASN A 1 483 ? 131.014 166.478 172.545 1.00 178.16 ? 483 ASN A O     1 
ATOM   3871 C  CB    . ASN A 1 483 ? 128.692 167.879 173.043 1.00 178.16 ? 483 ASN A CB    1 
ATOM   3872 C  CG    . ASN A 1 483 ? 127.314 168.314 173.498 1.00 178.16 ? 483 ASN A CG    1 
ATOM   3873 O  OD1   . ASN A 1 483 ? 126.424 168.550 172.681 1.00 178.16 ? 483 ASN A OD1   1 
ATOM   3874 N  ND2   . ASN A 1 483 ? 127.130 168.419 174.808 1.00 178.16 ? 483 ASN A ND2   1 
ATOM   3875 N  N     . SER A 1 484 ? 130.085 164.971 171.162 1.00 160.29 ? 484 SER A N     1 
ATOM   3876 C  CA    . SER A 1 484 ? 131.322 164.254 170.907 1.00 160.29 ? 484 SER A CA    1 
ATOM   3877 C  C     . SER A 1 484 ? 132.077 164.886 169.741 1.00 160.29 ? 484 SER A C     1 
ATOM   3878 O  O     . SER A 1 484 ? 131.514 165.622 168.930 1.00 160.29 ? 484 SER A O     1 
ATOM   3879 C  CB    . SER A 1 484 ? 131.035 162.783 170.613 1.00 160.29 ? 484 SER A CB    1 
ATOM   3880 O  OG    . SER A 1 484 ? 129.904 162.642 169.771 1.00 160.29 ? 484 SER A OG    1 
ATOM   3881 N  N     . LYS A 1 485 ? 133.370 164.579 169.665 1.00 151.78 ? 485 LYS A N     1 
ATOM   3882 C  CA    . LYS A 1 485 ? 134.247 165.146 168.650 1.00 151.78 ? 485 LYS A CA    1 
ATOM   3883 C  C     . LYS A 1 485 ? 134.994 164.036 167.927 1.00 151.78 ? 485 LYS A C     1 
ATOM   3884 O  O     . LYS A 1 485 ? 135.482 163.091 168.553 1.00 151.78 ? 485 LYS A O     1 
ATOM   3885 C  CB    . LYS A 1 485 ? 135.244 166.127 169.273 1.00 151.78 ? 485 LYS A CB    1 
ATOM   3886 C  CG    . LYS A 1 485 ? 134.784 167.574 169.251 1.00 151.78 ? 485 LYS A CG    1 
ATOM   3887 C  CD    . LYS A 1 485 ? 134.787 168.136 167.840 1.00 151.78 ? 485 LYS A CD    1 
ATOM   3888 C  CE    . LYS A 1 485 ? 134.862 169.653 167.858 1.00 151.78 ? 485 LYS A CE    1 
ATOM   3889 N  NZ    . LYS A 1 485 ? 136.234 170.136 168.172 1.00 151.78 ? 485 LYS A NZ    1 
ATOM   3890 N  N     . TYR A 1 486 ? 135.085 164.161 166.603 1.00 143.20 ? 486 TYR A N     1 
ATOM   3891 C  CA    . TYR A 1 486 ? 135.781 163.198 165.759 1.00 143.20 ? 486 TYR A CA    1 
ATOM   3892 C  C     . TYR A 1 486 ? 136.798 163.947 164.911 1.00 143.20 ? 486 TYR A C     1 
ATOM   3893 O  O     . TYR A 1 486 ? 136.432 164.866 164.172 1.00 143.20 ? 486 TYR A O     1 
ATOM   3894 C  CB    . TYR A 1 486 ? 134.792 162.434 164.873 1.00 143.20 ? 486 TYR A CB    1 
ATOM   3895 C  CG    . TYR A 1 486 ? 135.315 161.119 164.350 1.00 143.20 ? 486 TYR A CG    1 
ATOM   3896 C  CD1   . TYR A 1 486 ? 135.741 160.124 165.217 1.00 143.20 ? 486 TYR A CD1   1 
ATOM   3897 C  CD2   . TYR A 1 486 ? 135.374 160.869 162.987 1.00 143.20 ? 486 TYR A CD2   1 
ATOM   3898 C  CE1   . TYR A 1 486 ? 136.218 158.919 164.740 1.00 143.20 ? 486 TYR A CE1   1 
ATOM   3899 C  CE2   . TYR A 1 486 ? 135.849 159.670 162.501 1.00 143.20 ? 486 TYR A CE2   1 
ATOM   3900 C  CZ    . TYR A 1 486 ? 136.269 158.699 163.381 1.00 143.20 ? 486 TYR A CZ    1 
ATOM   3901 O  OH    . TYR A 1 486 ? 136.740 157.503 162.895 1.00 143.20 ? 486 TYR A OH    1 
ATOM   3902 N  N     . ILE A 1 487 ? 138.068 163.558 165.017 1.00 143.31 ? 487 ILE A N     1 
ATOM   3903 C  CA    . ILE A 1 487 ? 139.173 164.265 164.375 1.00 143.31 ? 487 ILE A CA    1 
ATOM   3904 C  C     . ILE A 1 487 ? 140.053 163.259 163.647 1.00 143.31 ? 487 ILE A C     1 
ATOM   3905 O  O     . ILE A 1 487 ? 140.443 162.237 164.223 1.00 143.31 ? 487 ILE A O     1 
ATOM   3906 C  CB    . ILE A 1 487 ? 140.005 165.064 165.396 1.00 143.31 ? 487 ILE A CB    1 
ATOM   3907 C  CG1   . ILE A 1 487 ? 139.120 166.053 166.158 1.00 143.31 ? 487 ILE A CG1   1 
ATOM   3908 C  CG2   . ILE A 1 487 ? 141.141 165.794 164.704 1.00 143.31 ? 487 ILE A CG2   1 
ATOM   3909 C  CD1   . ILE A 1 487 ? 139.831 166.763 167.285 1.00 143.31 ? 487 ILE A CD1   1 
ATOM   3910 N  N     . ILE A 1 488 ? 140.368 163.550 162.384 1.00 153.10 ? 488 ILE A N     1 
ATOM   3911 C  CA    . ILE A 1 488 ? 141.266 162.733 161.575 1.00 153.10 ? 488 ILE A CA    1 
ATOM   3912 C  C     . ILE A 1 488 ? 142.327 163.638 160.963 1.00 153.10 ? 488 ILE A C     1 
ATOM   3913 O  O     . ILE A 1 488 ? 142.001 164.697 160.414 1.00 153.10 ? 488 ILE A O     1 
ATOM   3914 C  CB    . ILE A 1 488 ? 140.516 161.969 160.465 1.00 153.10 ? 488 ILE A CB    1 
ATOM   3915 C  CG1   . ILE A 1 488 ? 139.109 161.582 160.924 1.00 153.10 ? 488 ILE A CG1   1 
ATOM   3916 C  CG2   . ILE A 1 488 ? 141.300 160.736 160.056 1.00 153.10 ? 488 ILE A CG2   1 
ATOM   3917 C  CD1   . ILE A 1 488 ? 138.344 160.760 159.912 1.00 153.10 ? 488 ILE A CD1   1 
ATOM   3918 N  N     . MET A 1 489 ? 143.588 163.223 161.054 1.00 132.13 ? 489 MET A N     1 
ATOM   3919 C  CA    . MET A 1 489 ? 144.708 163.955 160.475 1.00 132.13 ? 489 MET A CA    1 
ATOM   3920 C  C     . MET A 1 489 ? 144.970 163.450 159.064 1.00 132.13 ? 489 MET A C     1 
ATOM   3921 O  O     . MET A 1 489 ? 145.000 162.237 158.831 1.00 132.13 ? 489 MET A O     1 
ATOM   3922 C  CB    . MET A 1 489 ? 145.965 163.800 161.330 1.00 132.13 ? 489 MET A CB    1 
ATOM   3923 C  CG    . MET A 1 489 ? 145.805 164.285 162.754 1.00 132.13 ? 489 MET A CG    1 
ATOM   3924 S  SD    . MET A 1 489 ? 146.722 163.280 163.932 1.00 132.13 ? 489 MET A SD    1 
ATOM   3925 C  CE    . MET A 1 489 ? 146.375 164.158 165.450 1.00 132.13 ? 489 MET A CE    1 
ATOM   3926 N  N     . VAL A 1 490 ? 145.163 164.375 158.128 1.00 160.16 ? 490 VAL A N     1 
ATOM   3927 C  CA    . VAL A 1 490 ? 145.343 164.039 156.722 1.00 160.16 ? 490 VAL A CA    1 
ATOM   3928 C  C     . VAL A 1 490 ? 146.565 164.770 156.181 1.00 160.16 ? 490 VAL A C     1 
ATOM   3929 O  O     . VAL A 1 490 ? 146.767 165.958 156.458 1.00 160.16 ? 490 VAL A O     1 
ATOM   3930 C  CB    . VAL A 1 490 ? 144.085 164.375 155.891 1.00 160.16 ? 490 VAL A CB    1 
ATOM   3931 C  CG1   . VAL A 1 490 ? 143.670 165.823 156.096 1.00 160.16 ? 490 VAL A CG1   1 
ATOM   3932 C  CG2   . VAL A 1 490 ? 144.314 164.078 154.418 1.00 160.16 ? 490 VAL A CG2   1 
ATOM   3933 N  N     . GLU A 1 491 ? 147.390 164.051 155.425 1.00 171.75 ? 491 GLU A N     1 
ATOM   3934 C  CA    . GLU A 1 491 ? 148.530 164.649 154.749 1.00 171.75 ? 491 GLU A CA    1 
ATOM   3935 C  C     . GLU A 1 491 ? 148.049 165.503 153.573 1.00 171.75 ? 491 GLU A C     1 
ATOM   3936 O  O     . GLU A 1 491 ? 146.948 165.320 153.050 1.00 171.75 ? 491 GLU A O     1 
ATOM   3937 C  CB    . GLU A 1 491 ? 149.494 163.554 154.283 1.00 171.75 ? 491 GLU A CB    1 
ATOM   3938 C  CG    . GLU A 1 491 ? 150.791 164.039 153.655 1.00 171.75 ? 491 GLU A CG    1 
ATOM   3939 C  CD    . GLU A 1 491 ? 151.417 165.183 154.424 1.00 171.75 ? 491 GLU A CD    1 
ATOM   3940 O  OE1   . GLU A 1 491 ? 151.854 164.965 155.574 1.00 171.75 ? 491 GLU A OE1   1 
ATOM   3941 O  OE2   . GLU A 1 491 ? 151.476 166.302 153.873 1.00 171.75 ? 491 GLU A OE2   1 
ATOM   3942 N  N     . GLU A 1 492 ? 148.895 166.454 153.165 1.00 196.72 ? 492 GLU A N     1 
ATOM   3943 C  CA    . GLU A 1 492 ? 148.486 167.449 152.176 1.00 196.72 ? 492 GLU A CA    1 
ATOM   3944 C  C     . GLU A 1 492 ? 148.099 166.811 150.846 1.00 196.72 ? 492 GLU A C     1 
ATOM   3945 O  O     . GLU A 1 492 ? 147.103 167.206 150.229 1.00 196.72 ? 492 GLU A O     1 
ATOM   3946 C  CB    . GLU A 1 492 ? 149.603 168.471 151.971 1.00 196.72 ? 492 GLU A CB    1 
ATOM   3947 C  CG    . GLU A 1 492 ? 150.021 169.203 153.239 1.00 196.72 ? 492 GLU A CG    1 
ATOM   3948 C  CD    . GLU A 1 492 ? 148.901 170.034 153.836 1.00 196.72 ? 492 GLU A CD    1 
ATOM   3949 O  OE1   . GLU A 1 492 ? 148.028 170.497 153.073 1.00 196.72 ? 492 GLU A OE1   1 
ATOM   3950 O  OE2   . GLU A 1 492 ? 148.894 170.225 155.070 1.00 196.72 ? 492 GLU A OE2   1 
ATOM   3951 N  N     . ASP A 1 493 ? 148.870 165.831 150.384 1.00 216.44 ? 493 ASP A N     1 
ATOM   3952 C  CA    . ASP A 1 493 ? 148.615 165.199 149.095 1.00 216.44 ? 493 ASP A CA    1 
ATOM   3953 C  C     . ASP A 1 493 ? 147.604 164.062 149.174 1.00 216.44 ? 493 ASP A C     1 
ATOM   3954 O  O     . ASP A 1 493 ? 147.300 163.449 148.146 1.00 216.44 ? 493 ASP A O     1 
ATOM   3955 C  CB    . ASP A 1 493 ? 149.926 164.682 148.491 1.00 216.44 ? 493 ASP A CB    1 
ATOM   3956 C  CG    . ASP A 1 493 ? 150.718 163.825 149.459 1.00 216.44 ? 493 ASP A CG    1 
ATOM   3957 O  OD1   . ASP A 1 493 ? 150.205 163.535 150.558 1.00 216.44 ? 493 ASP A OD1   1 
ATOM   3958 O  OD2   . ASP A 1 493 ? 151.856 163.441 149.117 1.00 216.44 ? 493 ASP A OD2   1 
ATOM   3959 N  N     . GLU A 1 494 ? 147.078 163.769 150.362 1.00 200.78 ? 494 GLU A N     1 
ATOM   3960 C  CA    . GLU A 1 494 ? 146.179 162.644 150.571 1.00 200.78 ? 494 GLU A CA    1 
ATOM   3961 C  C     . GLU A 1 494 ? 144.716 163.062 150.669 1.00 200.78 ? 494 GLU A C     1 
ATOM   3962 O  O     . GLU A 1 494 ? 143.838 162.189 150.709 1.00 200.78 ? 494 GLU A O     1 
ATOM   3963 C  CB    . GLU A 1 494 ? 146.591 161.897 151.849 1.00 200.78 ? 494 GLU A CB    1 
ATOM   3964 C  CG    . GLU A 1 494 ? 146.106 160.458 151.982 1.00 200.78 ? 494 GLU A CG    1 
ATOM   3965 C  CD    . GLU A 1 494 ? 145.893 159.769 150.652 1.00 200.78 ? 494 GLU A CD    1 
ATOM   3966 O  OE1   . GLU A 1 494 ? 146.860 159.655 149.867 1.00 200.78 ? 494 GLU A OE1   1 
ATOM   3967 O  OE2   . GLU A 1 494 ? 144.757 159.322 150.400 1.00 200.78 ? 494 GLU A OE2   1 
ATOM   3968 N  N     . LYS A 1 495 ? 144.438 164.369 150.691 1.00 198.26 ? 495 LYS A N     1 
ATOM   3969 C  CA    . LYS A 1 495 ? 143.097 164.852 151.007 1.00 198.26 ? 495 LYS A CA    1 
ATOM   3970 C  C     . LYS A 1 495 ? 142.086 164.486 149.928 1.00 198.26 ? 495 LYS A C     1 
ATOM   3971 O  O     . LYS A 1 495 ? 140.928 164.197 150.239 1.00 198.26 ? 495 LYS A O     1 
ATOM   3972 C  CB    . LYS A 1 495 ? 143.118 166.364 151.228 1.00 198.26 ? 495 LYS A CB    1 
ATOM   3973 C  CG    . LYS A 1 495 ? 144.385 166.878 151.886 1.00 198.26 ? 495 LYS A CG    1 
ATOM   3974 C  CD    . LYS A 1 495 ? 144.349 168.388 152.055 1.00 198.26 ? 495 LYS A CD    1 
ATOM   3975 C  CE    . LYS A 1 495 ? 144.280 169.097 150.713 1.00 198.26 ? 495 LYS A CE    1 
ATOM   3976 N  NZ    . LYS A 1 495 ? 145.137 168.442 149.687 1.00 198.26 ? 495 LYS A NZ    1 
ATOM   3977 N  N     . ASN A 1 496 ? 142.491 164.511 148.657 1.00 201.59 ? 496 ASN A N     1 
ATOM   3978 C  CA    . ASN A 1 496 ? 141.554 164.181 147.586 1.00 201.59 ? 496 ASN A CA    1 
ATOM   3979 C  C     . ASN A 1 496 ? 141.075 162.738 147.703 1.00 201.59 ? 496 ASN A C     1 
ATOM   3980 O  O     . ASN A 1 496 ? 139.868 162.459 147.643 1.00 201.59 ? 496 ASN A O     1 
ATOM   3981 C  CB    . ASN A 1 496 ? 142.207 164.425 146.227 1.00 201.59 ? 496 ASN A CB    1 
ATOM   3982 C  CG    . ASN A 1 496 ? 142.863 165.787 146.133 1.00 201.59 ? 496 ASN A CG    1 
ATOM   3983 O  OD1   . ASN A 1 496 ? 144.041 165.944 146.453 1.00 201.59 ? 496 ASN A OD1   1 
ATOM   3984 N  ND2   . ASN A 1 496 ? 142.100 166.781 145.694 1.00 201.59 ? 496 ASN A ND2   1 
ATOM   3985 N  N     . LYS A 1 497 ? 142.013 161.806 147.876 1.00 192.66 ? 497 LYS A N     1 
ATOM   3986 C  CA    . LYS A 1 497 ? 141.642 160.405 148.028 1.00 192.66 ? 497 LYS A CA    1 
ATOM   3987 C  C     . LYS A 1 497 ? 140.853 160.187 149.312 1.00 192.66 ? 497 LYS A C     1 
ATOM   3988 O  O     . LYS A 1 497 ? 139.905 159.394 149.338 1.00 192.66 ? 497 LYS A O     1 
ATOM   3989 C  CB    . LYS A 1 497 ? 142.886 159.516 148.007 1.00 192.66 ? 497 LYS A CB    1 
ATOM   3990 C  CG    . LYS A 1 497 ? 143.981 159.930 147.026 1.00 192.66 ? 497 LYS A CG    1 
ATOM   3991 C  CD    . LYS A 1 497 ? 143.444 160.211 145.631 1.00 192.66 ? 497 LYS A CD    1 
ATOM   3992 C  CE    . LYS A 1 497 ? 144.441 161.023 144.823 1.00 192.66 ? 497 LYS A CE    1 
ATOM   3993 N  NZ    . LYS A 1 497 ? 144.942 162.197 145.592 1.00 192.66 ? 497 LYS A NZ    1 
ATOM   3994 N  N     . PHE A 1 498 ? 141.228 160.885 150.389 1.00 211.42 ? 498 PHE A N     1 
ATOM   3995 C  CA    . PHE A 1 498 ? 140.478 160.766 151.634 1.00 211.42 ? 498 PHE A CA    1 
ATOM   3996 C  C     . PHE A 1 498 ? 139.036 161.221 151.447 1.00 211.42 ? 498 PHE A C     1 
ATOM   3997 O  O     . PHE A 1 498 ? 138.103 160.564 151.920 1.00 211.42 ? 498 PHE A O     1 
ATOM   3998 C  CB    . PHE A 1 498 ? 141.164 161.578 152.732 1.00 211.42 ? 498 PHE A CB    1 
ATOM   3999 C  CG    . PHE A 1 498 ? 140.857 161.105 154.124 1.00 211.42 ? 498 PHE A CG    1 
ATOM   4000 C  CD1   . PHE A 1 498 ? 139.985 160.051 154.341 1.00 211.42 ? 498 PHE A CD1   1 
ATOM   4001 C  CD2   . PHE A 1 498 ? 141.442 161.718 155.219 1.00 211.42 ? 498 PHE A CD2   1 
ATOM   4002 C  CE1   . PHE A 1 498 ? 139.703 159.619 155.621 1.00 211.42 ? 498 PHE A CE1   1 
ATOM   4003 C  CE2   . PHE A 1 498 ? 141.165 161.289 156.501 1.00 211.42 ? 498 PHE A CE2   1 
ATOM   4004 C  CZ    . PHE A 1 498 ? 140.294 160.239 156.702 1.00 211.42 ? 498 PHE A CZ    1 
ATOM   4005 N  N     . GLN A 1 499 ? 138.835 162.338 150.747 1.00 218.58 ? 499 GLN A N     1 
ATOM   4006 C  CA    . GLN A 1 499 ? 137.489 162.845 150.513 1.00 218.58 ? 499 GLN A CA    1 
ATOM   4007 C  C     . GLN A 1 499 ? 136.678 161.889 149.650 1.00 218.58 ? 499 GLN A C     1 
ATOM   4008 O  O     . GLN A 1 499 ? 135.505 161.626 149.942 1.00 218.58 ? 499 GLN A O     1 
ATOM   4009 C  CB    . GLN A 1 499 ? 137.560 164.232 149.872 1.00 218.58 ? 499 GLN A CB    1 
ATOM   4010 C  CG    . GLN A 1 499 ? 136.437 164.541 148.891 1.00 218.58 ? 499 GLN A CG    1 
ATOM   4011 C  CD    . GLN A 1 499 ? 136.824 164.257 147.452 1.00 218.58 ? 499 GLN A CD    1 
ATOM   4012 O  OE1   . GLN A 1 499 ? 137.908 164.628 147.003 1.00 218.58 ? 499 GLN A OE1   1 
ATOM   4013 N  NE2   . GLN A 1 499 ? 135.935 163.594 146.721 1.00 218.58 ? 499 GLN A NE2   1 
ATOM   4014 N  N     . GLU A 1 500 ? 137.279 161.359 148.580 1.00 207.45 ? 500 GLU A N     1 
ATOM   4015 C  CA    . GLU A 1 500 ? 136.530 160.442 147.726 1.00 207.45 ? 500 GLU A CA    1 
ATOM   4016 C  C     . GLU A 1 500 ? 136.169 159.165 148.479 1.00 207.45 ? 500 GLU A C     1 
ATOM   4017 O  O     . GLU A 1 500 ? 135.052 158.649 148.339 1.00 207.45 ? 500 GLU A O     1 
ATOM   4018 C  CB    . GLU A 1 500 ? 137.312 160.135 146.444 1.00 207.45 ? 500 GLU A CB    1 
ATOM   4019 C  CG    . GLU A 1 500 ? 138.516 159.228 146.606 1.00 207.45 ? 500 GLU A CG    1 
ATOM   4020 C  CD    . GLU A 1 500 ? 139.313 159.079 145.326 1.00 207.45 ? 500 GLU A CD    1 
ATOM   4021 O  OE1   . GLU A 1 500 ? 138.782 159.425 144.251 1.00 207.45 ? 500 GLU A OE1   1 
ATOM   4022 O  OE2   . GLU A 1 500 ? 140.470 158.616 145.398 1.00 207.45 ? 500 GLU A OE2   1 
ATOM   4023 N  N     . ASP A 1 501 ? 137.083 158.662 149.314 1.00 202.25 ? 501 ASP A N     1 
ATOM   4024 C  CA    . ASP A 1 501 ? 136.778 157.480 150.110 1.00 202.25 ? 501 ASP A CA    1 
ATOM   4025 C  C     . ASP A 1 501 ? 135.696 157.775 151.140 1.00 202.25 ? 501 ASP A C     1 
ATOM   4026 O  O     . ASP A 1 501 ? 134.858 156.916 151.435 1.00 202.25 ? 501 ASP A O     1 
ATOM   4027 C  CB    . ASP A 1 501 ? 138.047 156.963 150.787 1.00 202.25 ? 501 ASP A CB    1 
ATOM   4028 C  CG    . ASP A 1 501 ? 138.947 156.205 149.833 1.00 202.25 ? 501 ASP A CG    1 
ATOM   4029 O  OD1   . ASP A 1 501 ? 138.682 156.241 148.613 1.00 202.25 ? 501 ASP A OD1   1 
ATOM   4030 O  OD2   . ASP A 1 501 ? 139.918 155.575 150.300 1.00 202.25 ? 501 ASP A OD2   1 
ATOM   4031 N  N     . LEU A 1 502 ? 135.696 158.986 151.701 1.00 201.23 ? 502 LEU A N     1 
ATOM   4032 C  CA    . LEU A 1 502 ? 134.643 159.365 152.638 1.00 201.23 ? 502 LEU A CA    1 
ATOM   4033 C  C     . LEU A 1 502 ? 133.285 159.416 151.948 1.00 201.23 ? 502 LEU A C     1 
ATOM   4034 O  O     . LEU A 1 502 ? 132.276 158.982 152.516 1.00 201.23 ? 502 LEU A O     1 
ATOM   4035 C  CB    . LEU A 1 502 ? 134.970 160.713 153.281 1.00 201.23 ? 502 LEU A CB    1 
ATOM   4036 C  CG    . LEU A 1 502 ? 133.945 161.237 154.286 1.00 201.23 ? 502 LEU A CG    1 
ATOM   4037 C  CD1   . LEU A 1 502 ? 133.889 160.338 155.510 1.00 201.23 ? 502 LEU A CD1   1 
ATOM   4038 C  CD2   . LEU A 1 502 ? 134.265 162.669 154.682 1.00 201.23 ? 502 LEU A CD2   1 
ATOM   4039 N  N     . ASN A 1 503 ? 133.239 159.953 150.727 1.00 203.20 ? 503 ASN A N     1 
ATOM   4040 C  CA    . ASN A 1 503 ? 131.986 159.947 149.975 1.00 203.20 ? 503 ASN A CA    1 
ATOM   4041 C  C     . ASN A 1 503 ? 131.527 158.524 149.685 1.00 203.20 ? 503 ASN A C     1 
ATOM   4042 O  O     . ASN A 1 503 ? 130.333 158.213 149.792 1.00 203.20 ? 503 ASN A O     1 
ATOM   4043 C  CB    . ASN A 1 503 ? 132.129 160.736 148.672 1.00 203.20 ? 503 ASN A CB    1 
ATOM   4044 C  CG    . ASN A 1 503 ? 132.773 162.091 148.872 1.00 203.20 ? 503 ASN A CG    1 
ATOM   4045 O  OD1   . ASN A 1 503 ? 133.667 162.483 148.122 1.00 203.20 ? 503 ASN A OD1   1 
ATOM   4046 N  ND2   . ASN A 1 503 ? 132.322 162.816 149.890 1.00 203.20 ? 503 ASN A ND2   1 
ATOM   4047 N  N     . GLN A 1 504 ? 132.466 157.646 149.317 1.00 203.56 ? 504 GLN A N     1 
ATOM   4048 C  CA    . GLN A 1 504 ? 132.111 156.247 149.091 1.00 203.56 ? 504 GLN A CA    1 
ATOM   4049 C  C     . GLN A 1 504 ? 131.546 155.614 150.355 1.00 203.56 ? 504 GLN A C     1 
ATOM   4050 O  O     . GLN A 1 504 ? 130.545 154.893 150.303 1.00 203.56 ? 504 GLN A O     1 
ATOM   4051 C  CB    . GLN A 1 504 ? 133.328 155.460 148.603 1.00 203.56 ? 504 GLN A CB    1 
ATOM   4052 C  CG    . GLN A 1 504 ? 133.912 155.946 147.290 1.00 203.56 ? 504 GLN A CG    1 
ATOM   4053 C  CD    . GLN A 1 504 ? 135.421 155.798 147.239 1.00 203.56 ? 504 GLN A CD    1 
ATOM   4054 O  OE1   . GLN A 1 504 ? 136.003 155.002 147.974 1.00 203.56 ? 504 GLN A OE1   1 
ATOM   4055 N  NE2   . GLN A 1 504 ? 136.062 156.572 146.370 1.00 203.56 ? 504 GLN A NE2   1 
ATOM   4056 N  N     . TYR A 1 505 ? 132.171 155.881 151.504 1.00 196.19 ? 505 TYR A N     1 
ATOM   4057 C  CA    . TYR A 1 505 ? 131.696 155.308 152.759 1.00 196.19 ? 505 TYR A CA    1 
ATOM   4058 C  C     . TYR A 1 505 ? 130.311 155.831 153.119 1.00 196.19 ? 505 TYR A C     1 
ATOM   4059 O  O     . TYR A 1 505 ? 129.452 155.071 153.583 1.00 196.19 ? 505 TYR A O     1 
ATOM   4060 C  CB    . TYR A 1 505 ? 132.690 155.606 153.882 1.00 196.19 ? 505 TYR A CB    1 
ATOM   4061 C  CG    . TYR A 1 505 ? 134.049 154.970 153.691 1.00 196.19 ? 505 TYR A CG    1 
ATOM   4062 C  CD1   . TYR A 1 505 ? 134.236 153.936 152.783 1.00 196.19 ? 505 TYR A CD1   1 
ATOM   4063 C  CD2   . TYR A 1 505 ? 135.148 155.406 154.419 1.00 196.19 ? 505 TYR A CD2   1 
ATOM   4064 C  CE1   . TYR A 1 505 ? 135.476 153.356 152.607 1.00 196.19 ? 505 TYR A CE1   1 
ATOM   4065 C  CE2   . TYR A 1 505 ? 136.393 154.830 154.250 1.00 196.19 ? 505 TYR A CE2   1 
ATOM   4066 C  CZ    . TYR A 1 505 ? 136.550 153.805 153.342 1.00 196.19 ? 505 TYR A CZ    1 
ATOM   4067 O  OH    . TYR A 1 505 ? 137.787 153.228 153.167 1.00 196.19 ? 505 TYR A OH    1 
ATOM   4068 N  N     . GLN A 1 506 ? 130.076 157.130 152.919 1.00 196.79 ? 506 GLN A N     1 
ATOM   4069 C  CA    . GLN A 1 506 ? 128.768 157.695 153.236 1.00 196.79 ? 506 GLN A CA    1 
ATOM   4070 C  C     . GLN A 1 506 ? 127.682 157.118 152.338 1.00 196.79 ? 506 GLN A C     1 
ATOM   4071 O  O     . GLN A 1 506 ? 126.592 156.772 152.812 1.00 196.79 ? 506 GLN A O     1 
ATOM   4072 C  CB    . GLN A 1 506 ? 128.812 159.218 153.123 1.00 196.79 ? 506 GLN A CB    1 
ATOM   4073 C  CG    . GLN A 1 506 ? 129.549 159.891 154.268 1.00 196.79 ? 506 GLN A CG    1 
ATOM   4074 C  CD    . GLN A 1 506 ? 128.939 159.567 155.619 1.00 196.79 ? 506 GLN A CD    1 
ATOM   4075 O  OE1   . GLN A 1 506 ? 129.414 158.682 156.331 1.00 196.79 ? 506 GLN A OE1   1 
ATOM   4076 N  NE2   . GLN A 1 506 ? 127.882 160.286 155.979 1.00 196.79 ? 506 GLN A NE2   1 
ATOM   4077 N  N     . GLU A 1 507 ? 127.960 156.994 151.037 1.00 214.85 ? 507 GLU A N     1 
ATOM   4078 C  CA    . GLU A 1 507 ? 126.971 156.395 150.149 1.00 214.85 ? 507 GLU A CA    1 
ATOM   4079 C  C     . GLU A 1 507 ? 126.755 154.920 150.472 1.00 214.85 ? 507 GLU A C     1 
ATOM   4080 O  O     . GLU A 1 507 ? 125.630 154.418 150.345 1.00 214.85 ? 507 GLU A O     1 
ATOM   4081 C  CB    . GLU A 1 507 ? 127.383 156.587 148.686 1.00 214.85 ? 507 GLU A CB    1 
ATOM   4082 C  CG    . GLU A 1 507 ? 128.331 155.539 148.129 1.00 214.85 ? 507 GLU A CG    1 
ATOM   4083 C  CD    . GLU A 1 507 ? 129.160 156.059 146.972 1.00 214.85 ? 507 GLU A CD    1 
ATOM   4084 O  OE1   . GLU A 1 507 ? 128.818 157.130 146.430 1.00 214.85 ? 507 GLU A OE1   1 
ATOM   4085 O  OE2   . GLU A 1 507 ? 130.150 155.394 146.602 1.00 214.85 ? 507 GLU A OE2   1 
ATOM   4086 N  N     . ILE A 1 508 ? 127.804 154.221 150.915 1.00 206.49 ? 508 ILE A N     1 
ATOM   4087 C  CA    . ILE A 1 508 ? 127.662 152.824 151.314 1.00 206.49 ? 508 ILE A CA    1 
ATOM   4088 C  C     . ILE A 1 508 ? 126.754 152.715 152.531 1.00 206.49 ? 508 ILE A C     1 
ATOM   4089 O  O     . ILE A 1 508 ? 125.878 151.845 152.600 1.00 206.49 ? 508 ILE A O     1 
ATOM   4090 C  CB    . ILE A 1 508 ? 129.044 152.201 151.579 1.00 206.49 ? 508 ILE A CB    1 
ATOM   4091 C  CG1   . ILE A 1 508 ? 129.678 151.731 150.270 1.00 206.49 ? 508 ILE A CG1   1 
ATOM   4092 C  CG2   . ILE A 1 508 ? 128.939 151.042 152.560 1.00 206.49 ? 508 ILE A CG2   1 
ATOM   4093 C  CD1   . ILE A 1 508 ? 131.055 151.139 150.447 1.00 206.49 ? 508 ILE A CD1   1 
ATOM   4094 N  N     . GLU A 1 509 ? 126.946 153.602 153.509 1.00 208.11 ? 509 GLU A N     1 
ATOM   4095 C  CA    . GLU A 1 509 ? 126.081 153.600 154.684 1.00 208.11 ? 509 GLU A CA    1 
ATOM   4096 C  C     . GLU A 1 509 ? 124.640 153.914 154.304 1.00 208.11 ? 509 GLU A C     1 
ATOM   4097 O  O     . GLU A 1 509 ? 123.700 153.304 154.833 1.00 208.11 ? 509 GLU A O     1 
ATOM   4098 C  CB    . GLU A 1 509 ? 126.599 154.600 155.717 1.00 208.11 ? 509 GLU A CB    1 
ATOM   4099 C  CG    . GLU A 1 509 ? 125.877 154.543 157.051 1.00 208.11 ? 509 GLU A CG    1 
ATOM   4100 C  CD    . GLU A 1 509 ? 126.603 155.311 158.137 1.00 208.11 ? 509 GLU A CD    1 
ATOM   4101 O  OE1   . GLU A 1 509 ? 127.647 155.924 157.834 1.00 208.11 ? 509 GLU A OE1   1 
ATOM   4102 O  OE2   . GLU A 1 509 ? 126.131 155.297 159.294 1.00 208.11 ? 509 GLU A OE2   1 
ATOM   4103 N  N     . LYS A 1 510 ? 124.446 154.857 153.381 1.00 207.63 ? 510 LYS A N     1 
ATOM   4104 C  CA    . LYS A 1 510 ? 123.099 155.203 152.935 1.00 207.63 ? 510 LYS A CA    1 
ATOM   4105 C  C     . LYS A 1 510 ? 122.408 154.008 152.283 1.00 207.63 ? 510 LYS A C     1 
ATOM   4106 O  O     . LYS A 1 510 ? 121.259 153.680 152.613 1.00 207.63 ? 510 LYS A O     1 
ATOM   4107 C  CB    . LYS A 1 510 ? 123.168 156.387 151.967 1.00 207.63 ? 510 LYS A CB    1 
ATOM   4108 C  CG    . LYS A 1 510 ? 121.936 156.590 151.096 1.00 207.63 ? 510 LYS A CG    1 
ATOM   4109 C  CD    . LYS A 1 510 ? 120.703 156.916 151.920 1.00 207.63 ? 510 LYS A CD    1 
ATOM   4110 C  CE    . LYS A 1 510 ? 119.450 156.875 151.062 1.00 207.63 ? 510 LYS A CE    1 
ATOM   4111 N  NZ    . LYS A 1 510 ? 118.224 157.184 151.848 1.00 207.63 ? 510 LYS A NZ    1 
ATOM   4112 N  N     . ILE A 1 511 ? 123.097 153.341 151.354 1.00 224.64 ? 511 ILE A N     1 
ATOM   4113 C  CA    . ILE A 1 511 ? 122.473 152.217 150.660 1.00 224.64 ? 511 ILE A CA    1 
ATOM   4114 C  C     . ILE A 1 511 ? 122.286 151.040 151.609 1.00 224.64 ? 511 ILE A C     1 
ATOM   4115 O  O     . ILE A 1 511 ? 121.355 150.244 151.449 1.00 224.64 ? 511 ILE A O     1 
ATOM   4116 C  CB    . ILE A 1 511 ? 123.276 151.821 149.407 1.00 224.64 ? 511 ILE A CB    1 
ATOM   4117 C  CG1   . ILE A 1 511 ? 124.725 151.491 149.761 1.00 224.64 ? 511 ILE A CG1   1 
ATOM   4118 C  CG2   . ILE A 1 511 ? 123.224 152.932 148.370 1.00 224.64 ? 511 ILE A CG2   1 
ATOM   4119 C  CD1   . ILE A 1 511 ? 125.517 150.908 148.610 1.00 224.64 ? 511 ILE A CD1   1 
ATOM   4120 N  N     . LEU A 1 512 ? 123.164 150.902 152.605 1.00 223.37 ? 512 LEU A N     1 
ATOM   4121 C  CA    . LEU A 1 512 ? 122.976 149.866 153.615 1.00 223.37 ? 512 LEU A CA    1 
ATOM   4122 C  C     . LEU A 1 512 ? 121.726 150.126 154.442 1.00 223.37 ? 512 LEU A C     1 
ATOM   4123 O  O     . LEU A 1 512 ? 120.960 149.201 154.734 1.00 223.37 ? 512 LEU A O     1 
ATOM   4124 C  CB    . LEU A 1 512 ? 124.204 149.784 154.522 1.00 223.37 ? 512 LEU A CB    1 
ATOM   4125 C  CG    . LEU A 1 512 ? 124.274 148.570 155.450 1.00 223.37 ? 512 LEU A CG    1 
ATOM   4126 C  CD1   . LEU A 1 512 ? 124.396 147.283 154.648 1.00 223.37 ? 512 LEU A CD1   1 
ATOM   4127 C  CD2   . LEU A 1 512 ? 125.425 148.708 156.435 1.00 223.37 ? 512 LEU A CD2   1 
ATOM   4128 N  N     . LEU A 1 513 ? 121.509 151.383 154.836 1.00 201.44 ? 513 LEU A N     1 
ATOM   4129 C  CA    . LEU A 1 513 ? 120.308 151.718 155.592 1.00 201.44 ? 513 LEU A CA    1 
ATOM   4130 C  C     . LEU A 1 513 ? 119.057 151.473 154.755 1.00 201.44 ? 513 LEU A C     1 
ATOM   4131 O  O     . LEU A 1 513 ? 118.061 150.936 155.254 1.00 201.44 ? 513 LEU A O     1 
ATOM   4132 C  CB    . LEU A 1 513 ? 120.376 153.176 156.055 1.00 201.44 ? 513 LEU A CB    1 
ATOM   4133 C  CG    . LEU A 1 513 ? 119.199 153.864 156.762 1.00 201.44 ? 513 LEU A CG    1 
ATOM   4134 C  CD1   . LEU A 1 513 ? 118.399 152.917 157.653 1.00 201.44 ? 513 LEU A CD1   1 
ATOM   4135 C  CD2   . LEU A 1 513 ? 119.688 155.065 157.560 1.00 201.44 ? 513 LEU A CD2   1 
ATOM   4136 N  N     . ARG A 1 514 ? 119.096 151.841 153.473 1.00 214.73 ? 514 ARG A N     1 
ATOM   4137 C  CA    . ARG A 1 514 ? 117.901 151.700 152.644 1.00 214.73 ? 514 ARG A CA    1 
ATOM   4138 C  C     . ARG A 1 514 ? 117.619 150.247 152.270 1.00 214.73 ? 514 ARG A C     1 
ATOM   4139 O  O     . ARG A 1 514 ? 116.453 149.842 152.199 1.00 214.73 ? 514 ARG A O     1 
ATOM   4140 C  CB    . ARG A 1 514 ? 118.031 152.558 151.385 1.00 214.73 ? 514 ARG A CB    1 
ATOM   4141 C  CG    . ARG A 1 514 ? 117.412 153.949 151.497 1.00 214.73 ? 514 ARG A CG    1 
ATOM   4142 C  CD    . ARG A 1 514 ? 115.880 153.922 151.536 1.00 214.73 ? 514 ARG A CD    1 
ATOM   4143 N  NE    . ARG A 1 514 ? 115.328 153.448 152.802 1.00 214.73 ? 514 ARG A NE    1 
ATOM   4144 C  CZ    . ARG A 1 514 ? 115.415 154.097 153.956 1.00 214.73 ? 514 ARG A CZ    1 
ATOM   4145 N  NH1   . ARG A 1 514 ? 116.008 155.276 154.045 1.00 214.73 ? 514 ARG A NH1   1 
ATOM   4146 N  NH2   . ARG A 1 514 ? 114.888 153.549 155.047 1.00 214.73 ? 514 ARG A NH2   1 
ATOM   4147 N  N     . LEU A 1 515 ? 118.662 149.451 152.030 1.00 242.83 ? 515 LEU A N     1 
ATOM   4148 C  CA    . LEU A 1 515 ? 118.463 148.097 151.520 1.00 242.83 ? 515 LEU A CA    1 
ATOM   4149 C  C     . LEU A 1 515 ? 118.005 147.130 152.606 1.00 242.83 ? 515 LEU A C     1 
ATOM   4150 O  O     . LEU A 1 515 ? 117.355 146.124 152.299 1.00 242.83 ? 515 LEU A O     1 
ATOM   4151 C  CB    . LEU A 1 515 ? 119.753 147.586 150.878 1.00 242.83 ? 515 LEU A CB    1 
ATOM   4152 C  CG    . LEU A 1 515 ? 119.948 147.874 149.387 1.00 242.83 ? 515 LEU A CG    1 
ATOM   4153 C  CD1   . LEU A 1 515 ? 121.168 147.136 148.856 1.00 242.83 ? 515 LEU A CD1   1 
ATOM   4154 C  CD2   . LEU A 1 515 ? 118.704 147.498 148.597 1.00 242.83 ? 515 LEU A CD2   1 
ATOM   4155 N  N     . CYS A 1 516 ? 118.334 147.408 153.869 1.00 231.09 ? 516 CYS A N     1 
ATOM   4156 C  CA    . CYS A 1 516 ? 118.089 146.447 154.938 1.00 231.09 ? 516 CYS A CA    1 
ATOM   4157 C  C     . CYS A 1 516 ? 116.607 146.183 155.179 1.00 231.09 ? 516 CYS A C     1 
ATOM   4158 O  O     . CYS A 1 516 ? 116.268 145.163 155.787 1.00 231.09 ? 516 CYS A O     1 
ATOM   4159 C  CB    . CYS A 1 516 ? 118.750 146.930 156.231 1.00 231.09 ? 516 CYS A CB    1 
ATOM   4160 S  SG    . CYS A 1 516 ? 117.889 148.286 157.056 1.00 231.09 ? 516 CYS A SG    1 
ATOM   4161 N  N     . HIS A 1 517 ? 115.722 147.062 154.718 1.00 230.20 ? 517 HIS A N     1 
ATOM   4162 C  CA    . HIS A 1 517 ? 114.298 146.904 154.978 1.00 230.20 ? 517 HIS A CA    1 
ATOM   4163 C  C     . HIS A 1 517 ? 113.639 146.013 153.931 1.00 230.20 ? 517 HIS A C     1 
ATOM   4164 O  O     . HIS A 1 517 ? 113.958 146.086 152.741 1.00 230.20 ? 517 HIS A O     1 
ATOM   4165 C  CB    . HIS A 1 517 ? 113.607 148.267 155.008 1.00 230.20 ? 517 HIS A CB    1 
ATOM   4166 C  CG    . HIS A 1 517 ? 112.700 148.457 156.183 1.00 230.20 ? 517 HIS A CG    1 
ATOM   4167 N  ND1   . HIS A 1 517 ? 111.709 147.557 156.511 1.00 230.20 ? 517 HIS A ND1   1 
ATOM   4168 C  CD2   . HIS A 1 517 ? 112.632 149.444 157.108 1.00 230.20 ? 517 HIS A CD2   1 
ATOM   4169 C  CE1   . HIS A 1 517 ? 111.071 147.980 157.587 1.00 230.20 ? 517 HIS A CE1   1 
ATOM   4170 N  NE2   . HIS A 1 517 ? 111.611 149.123 157.970 1.00 230.20 ? 517 HIS A NE2   1 
ATOM   4171 N  N     . ASN A 1 518 ? 112.713 145.168 154.391 1.00 240.47 ? 518 ASN A N     1 
ATOM   4172 C  CA    . ASN A 1 518 ? 111.857 144.353 153.527 1.00 240.47 ? 518 ASN A CA    1 
ATOM   4173 C  C     . ASN A 1 518 ? 112.678 143.431 152.621 1.00 240.47 ? 518 ASN A C     1 
ATOM   4174 O  O     . ASN A 1 518 ? 112.681 143.556 151.395 1.00 240.47 ? 518 ASN A O     1 
ATOM   4175 C  CB    . ASN A 1 518 ? 110.917 145.240 152.703 1.00 240.47 ? 518 ASN A CB    1 
ATOM   4176 C  CG    . ASN A 1 518 ? 109.586 144.573 152.421 1.00 240.47 ? 518 ASN A CG    1 
ATOM   4177 O  OD1   . ASN A 1 518 ? 109.486 143.346 152.399 1.00 240.47 ? 518 ASN A OD1   1 
ATOM   4178 N  ND2   . ASN A 1 518 ? 108.554 145.380 152.205 1.00 240.47 ? 518 ASN A ND2   1 
ATOM   4179 N  N     . ARG A 1 519 ? 113.379 142.493 153.253 1.00 230.97 ? 519 ARG A N     1 
ATOM   4180 C  CA    . ARG A 1 519 ? 114.167 141.493 152.544 1.00 230.97 ? 519 ARG A CA    1 
ATOM   4181 C  C     . ARG A 1 519 ? 113.604 140.105 152.820 1.00 230.97 ? 519 ARG A C     1 
ATOM   4182 O  O     . ARG A 1 519 ? 113.185 139.804 153.942 1.00 230.97 ? 519 ARG A O     1 
ATOM   4183 C  CB    . ARG A 1 519 ? 115.643 141.560 152.952 1.00 230.97 ? 519 ARG A CB    1 
ATOM   4184 C  CG    . ARG A 1 519 ? 116.565 140.731 152.070 1.00 230.97 ? 519 ARG A CG    1 
ATOM   4185 C  CD    . ARG A 1 519 ? 117.985 141.275 152.087 1.00 230.97 ? 519 ARG A CD    1 
ATOM   4186 N  NE    . ARG A 1 519 ? 118.066 142.605 151.495 1.00 230.97 ? 519 ARG A NE    1 
ATOM   4187 C  CZ    . ARG A 1 519 ? 118.191 142.841 150.196 1.00 230.97 ? 519 ARG A CZ    1 
ATOM   4188 N  NH1   . ARG A 1 519 ? 118.257 141.853 149.317 1.00 230.97 ? 519 ARG A NH1   1 
ATOM   4189 N  NH2   . ARG A 1 519 ? 118.252 144.098 149.767 1.00 230.97 ? 519 ARG A NH2   1 
ATOM   4190 N  N     . ASP A 1 520 ? 113.596 139.265 151.788 1.00 231.35 ? 520 ASP A N     1 
ATOM   4191 C  CA    . ASP A 1 520 ? 113.007 137.937 151.890 1.00 231.35 ? 520 ASP A CA    1 
ATOM   4192 C  C     . ASP A 1 520 ? 113.895 137.011 152.720 1.00 231.35 ? 520 ASP A C     1 
ATOM   4193 O  O     . ASP A 1 520 ? 115.092 137.253 152.900 1.00 231.35 ? 520 ASP A O     1 
ATOM   4194 C  CB    . ASP A 1 520 ? 112.783 137.355 150.491 1.00 231.35 ? 520 ASP A CB    1 
ATOM   4195 C  CG    . ASP A 1 520 ? 112.202 135.953 150.521 1.00 231.35 ? 520 ASP A CG    1 
ATOM   4196 O  OD1   . ASP A 1 520 ? 111.303 135.700 151.350 1.00 231.35 ? 520 ASP A OD1   1 
ATOM   4197 O  OD2   . ASP A 1 520 ? 112.644 135.106 149.716 1.00 231.35 ? 520 ASP A OD2   1 
ATOM   4198 N  N     . ALA A 1 521 ? 113.288 135.943 153.235 1.00 230.74 ? 521 ALA A N     1 
ATOM   4199 C  CA    . ALA A 1 521 ? 114.005 134.978 154.053 1.00 230.74 ? 521 ALA A CA    1 
ATOM   4200 C  C     . ALA A 1 521 ? 115.069 134.256 153.225 1.00 230.74 ? 521 ALA A C     1 
ATOM   4201 O  O     . ALA A 1 521 ? 114.936 134.125 152.004 1.00 230.74 ? 521 ALA A O     1 
ATOM   4202 C  CB    . ALA A 1 521 ? 113.028 133.968 154.652 1.00 230.74 ? 521 ALA A CB    1 
ATOM   4203 N  N     . PRO A 1 522 ? 116.139 133.780 153.863 1.00 230.56 ? 522 PRO A N     1 
ATOM   4204 C  CA    . PRO A 1 522 ? 117.220 133.133 153.112 1.00 230.56 ? 522 PRO A CA    1 
ATOM   4205 C  C     . PRO A 1 522 ? 116.796 131.803 152.507 1.00 230.56 ? 522 PRO A C     1 
ATOM   4206 O  O     . PRO A 1 522 ? 115.840 131.163 152.949 1.00 230.56 ? 522 PRO A O     1 
ATOM   4207 C  CB    . PRO A 1 522 ? 118.312 132.930 154.170 1.00 230.56 ? 522 PRO A CB    1 
ATOM   4208 C  CG    . PRO A 1 522 ? 117.578 132.895 155.463 1.00 230.56 ? 522 PRO A CG    1 
ATOM   4209 C  CD    . PRO A 1 522 ? 116.445 133.865 155.301 1.00 230.56 ? 522 PRO A CD    1 
ATOM   4210 N  N     . SER A 1 523 ? 117.531 131.396 151.475 1.00 234.73 ? 523 SER A N     1 
ATOM   4211 C  CA    . SER A 1 523 ? 117.285 130.124 150.811 1.00 234.73 ? 523 SER A CA    1 
ATOM   4212 C  C     . SER A 1 523 ? 118.325 129.096 151.242 1.00 234.73 ? 523 SER A C     1 
ATOM   4213 O  O     . SER A 1 523 ? 119.531 129.347 151.159 1.00 234.73 ? 523 SER A O     1 
ATOM   4214 C  CB    . SER A 1 523 ? 117.312 130.303 149.293 1.00 234.73 ? 523 SER A CB    1 
ATOM   4215 O  OG    . SER A 1 523 ? 116.293 131.189 148.865 1.00 234.73 ? 523 SER A OG    1 
ATOM   4216 N  N     . GLU A 1 524 ? 117.851 127.935 151.704 1.00 227.46 ? 524 GLU A N     1 
ATOM   4217 C  CA    . GLU A 1 524 ? 118.747 126.871 152.146 1.00 227.46 ? 524 GLU A CA    1 
ATOM   4218 C  C     . GLU A 1 524 ? 119.556 126.276 151.001 1.00 227.46 ? 524 GLU A C     1 
ATOM   4219 O  O     . GLU A 1 524 ? 120.600 125.657 151.247 1.00 227.46 ? 524 GLU A O     1 
ATOM   4220 C  CB    . GLU A 1 524 ? 117.948 125.770 152.846 1.00 227.46 ? 524 GLU A CB    1 
ATOM   4221 C  CG    . GLU A 1 524 ? 116.799 125.203 152.021 1.00 227.46 ? 524 GLU A CG    1 
ATOM   4222 C  CD    . GLU A 1 524 ? 115.533 126.036 152.116 1.00 227.46 ? 524 GLU A CD    1 
ATOM   4223 O  OE1   . GLU A 1 524 ? 115.576 127.123 152.729 1.00 227.46 ? 524 GLU A OE1   1 
ATOM   4224 O  OE2   . GLU A 1 524 ? 114.494 125.603 151.574 1.00 227.46 ? 524 GLU A OE2   1 
ATOM   4225 N  N     . GLU A 1 525 ? 119.093 126.437 149.758 1.00 236.44 ? 525 GLU A N     1 
ATOM   4226 C  CA    . GLU A 1 525 ? 119.895 126.017 148.616 1.00 236.44 ? 525 GLU A CA    1 
ATOM   4227 C  C     . GLU A 1 525 ? 121.212 126.776 148.564 1.00 236.44 ? 525 GLU A C     1 
ATOM   4228 O  O     . GLU A 1 525 ? 122.251 126.200 148.227 1.00 236.44 ? 525 GLU A O     1 
ATOM   4229 C  CB    . GLU A 1 525 ? 119.109 126.207 147.319 1.00 236.44 ? 525 GLU A CB    1 
ATOM   4230 C  CG    . GLU A 1 525 ? 117.806 125.420 147.261 1.00 236.44 ? 525 GLU A CG    1 
ATOM   4231 C  CD    . GLU A 1 525 ? 116.645 126.148 147.913 1.00 236.44 ? 525 GLU A CD    1 
ATOM   4232 O  OE1   . GLU A 1 525 ? 116.865 127.241 148.472 1.00 236.44 ? 525 GLU A OE1   1 
ATOM   4233 O  OE2   . GLU A 1 525 ? 115.513 125.623 147.868 1.00 236.44 ? 525 GLU A OE2   1 
ATOM   4234 N  N     . ASP A 1 526 ? 121.190 128.064 148.905 1.00 221.84 ? 526 ASP A N     1 
ATOM   4235 C  CA    . ASP A 1 526 ? 122.437 128.803 149.055 1.00 221.84 ? 526 ASP A CA    1 
ATOM   4236 C  C     . ASP A 1 526 ? 123.255 128.275 150.226 1.00 221.84 ? 526 ASP A C     1 
ATOM   4237 O  O     . ASP A 1 526 ? 124.490 128.291 150.179 1.00 221.84 ? 526 ASP A O     1 
ATOM   4238 C  CB    . ASP A 1 526 ? 122.141 130.289 149.237 1.00 221.84 ? 526 ASP A CB    1 
ATOM   4239 C  CG    . ASP A 1 526 ? 121.388 130.880 148.064 1.00 221.84 ? 526 ASP A CG    1 
ATOM   4240 O  OD1   . ASP A 1 526 ? 121.349 130.235 146.995 1.00 221.84 ? 526 ASP A OD1   1 
ATOM   4241 O  OD2   . ASP A 1 526 ? 120.831 131.988 148.212 1.00 221.84 ? 526 ASP A OD2   1 
ATOM   4242 N  N     . PHE A 1 527 ? 122.585 127.806 151.283 1.00 232.19 ? 527 PHE A N     1 
ATOM   4243 C  CA    . PHE A 1 527 ? 123.297 127.296 152.451 1.00 232.19 ? 527 PHE A CA    1 
ATOM   4244 C  C     . PHE A 1 527 ? 124.086 126.037 152.116 1.00 232.19 ? 527 PHE A C     1 
ATOM   4245 O  O     . PHE A 1 527 ? 125.234 125.881 152.546 1.00 232.19 ? 527 PHE A O     1 
ATOM   4246 C  CB    . PHE A 1 527 ? 122.313 127.023 153.590 1.00 232.19 ? 527 PHE A CB    1 
ATOM   4247 C  CG    . PHE A 1 527 ? 122.972 126.599 154.873 1.00 232.19 ? 527 PHE A CG    1 
ATOM   4248 C  CD1   . PHE A 1 527 ? 124.209 127.106 155.236 1.00 232.19 ? 527 PHE A CD1   1 
ATOM   4249 C  CD2   . PHE A 1 527 ? 122.356 125.687 155.714 1.00 232.19 ? 527 PHE A CD2   1 
ATOM   4250 C  CE1   . PHE A 1 527 ? 124.813 126.715 156.412 1.00 232.19 ? 527 PHE A CE1   1 
ATOM   4251 C  CE2   . PHE A 1 527 ? 122.957 125.293 156.892 1.00 232.19 ? 527 PHE A CE2   1 
ATOM   4252 C  CZ    . PHE A 1 527 ? 124.188 125.807 157.241 1.00 232.19 ? 527 PHE A CZ    1 
ATOM   4253 N  N     . ASP A 1 528 ? 123.487 125.114 151.365 1.00 240.10 ? 528 ASP A N     1 
ATOM   4254 C  CA    . ASP A 1 528 ? 124.236 123.923 150.982 1.00 240.10 ? 528 ASP A CA    1 
ATOM   4255 C  C     . ASP A 1 528 ? 124.956 124.084 149.648 1.00 240.10 ? 528 ASP A C     1 
ATOM   4256 O  O     . ASP A 1 528 ? 125.588 123.127 149.186 1.00 240.10 ? 528 ASP A O     1 
ATOM   4257 C  CB    . ASP A 1 528 ? 123.320 122.694 150.938 1.00 240.10 ? 528 ASP A CB    1 
ATOM   4258 C  CG    . ASP A 1 528 ? 121.974 122.987 150.316 1.00 240.10 ? 528 ASP A CG    1 
ATOM   4259 O  OD1   . ASP A 1 528 ? 120.962 122.430 150.793 1.00 240.10 ? 528 ASP A OD1   1 
ATOM   4260 O  OD2   . ASP A 1 528 ? 121.928 123.750 149.334 1.00 240.10 ? 528 ASP A OD2   1 
ATOM   4261 N  N     . SER A 1 529 ? 124.873 125.260 149.023 1.00 232.05 ? 529 SER A N     1 
ATOM   4262 C  CA    . SER A 1 529 ? 125.544 125.475 147.744 1.00 232.05 ? 529 SER A CA    1 
ATOM   4263 C  C     . SER A 1 529 ? 127.061 125.455 147.893 1.00 232.05 ? 529 SER A C     1 
ATOM   4264 O  O     . SER A 1 529 ? 127.757 124.748 147.154 1.00 232.05 ? 529 SER A O     1 
ATOM   4265 C  CB    . SER A 1 529 ? 125.082 126.798 147.133 1.00 232.05 ? 529 SER A CB    1 
ATOM   4266 O  OG    . SER A 1 529 ? 125.739 127.896 147.741 1.00 232.05 ? 529 SER A OG    1 
ATOM   4267 N  N     . PHE A 1 530 ? 127.596 126.222 148.841 1.00 198.74 ? 530 PHE A N     1 
ATOM   4268 C  CA    . PHE A 1 530 ? 129.042 126.348 148.960 1.00 198.74 ? 530 PHE A CA    1 
ATOM   4269 C  C     . PHE A 1 530 ? 129.666 125.059 149.483 1.00 198.74 ? 530 PHE A C     1 
ATOM   4270 O  O     . PHE A 1 530 ? 129.095 124.369 150.332 1.00 198.74 ? 530 PHE A O     1 
ATOM   4271 C  CB    . PHE A 1 530 ? 129.415 127.528 149.863 1.00 198.74 ? 530 PHE A CB    1 
ATOM   4272 C  CG    . PHE A 1 530 ? 128.825 127.460 151.245 1.00 198.74 ? 530 PHE A CG    1 
ATOM   4273 C  CD1   . PHE A 1 530 ? 129.447 126.738 152.250 1.00 198.74 ? 530 PHE A CD1   1 
ATOM   4274 C  CD2   . PHE A 1 530 ? 127.669 128.160 151.548 1.00 198.74 ? 530 PHE A CD2   1 
ATOM   4275 C  CE1   . PHE A 1 530 ? 128.909 126.685 153.520 1.00 198.74 ? 530 PHE A CE1   1 
ATOM   4276 C  CE2   . PHE A 1 530 ? 127.132 128.121 152.820 1.00 198.74 ? 530 PHE A CE2   1 
ATOM   4277 C  CZ    . PHE A 1 530 ? 127.750 127.379 153.805 1.00 198.74 ? 530 PHE A CZ    1 
ATOM   4278 N  N     . GLU A 1 531 ? 130.845 124.735 148.956 1.00 224.51 ? 531 GLU A N     1 
ATOM   4279 C  CA    . GLU A 1 531 ? 131.578 123.540 149.367 1.00 224.51 ? 531 GLU A CA    1 
ATOM   4280 C  C     . GLU A 1 531 ? 133.045 123.752 149.020 1.00 224.51 ? 531 GLU A C     1 
ATOM   4281 O  O     . GLU A 1 531 ? 133.396 123.839 147.839 1.00 224.51 ? 531 GLU A O     1 
ATOM   4282 C  CB    . GLU A 1 531 ? 131.027 122.291 148.684 1.00 224.51 ? 531 GLU A CB    1 
ATOM   4283 C  CG    . GLU A 1 531 ? 131.139 121.027 149.521 1.00 224.51 ? 531 GLU A CG    1 
ATOM   4284 C  CD    . GLU A 1 531 ? 132.576 120.584 149.722 1.00 224.51 ? 531 GLU A CD    1 
ATOM   4285 O  OE1   . GLU A 1 531 ? 133.383 120.726 148.780 1.00 224.51 ? 531 GLU A OE1   1 
ATOM   4286 O  OE2   . GLU A 1 531 ? 132.898 120.096 150.826 1.00 224.51 ? 531 GLU A OE2   1 
ATOM   4287 N  N     . ASP A 1 532 ? 133.894 123.835 150.043 1.00 257.30 ? 532 ASP A N     1 
ATOM   4288 C  CA    . ASP A 1 532 ? 135.323 124.025 149.850 1.00 257.30 ? 532 ASP A CA    1 
ATOM   4289 C  C     . ASP A 1 532 ? 136.154 122.810 150.236 1.00 257.30 ? 532 ASP A C     1 
ATOM   4290 O  O     . ASP A 1 532 ? 137.315 122.720 149.820 1.00 257.30 ? 532 ASP A O     1 
ATOM   4291 C  CB    . ASP A 1 532 ? 135.812 125.242 150.651 1.00 257.30 ? 532 ASP A CB    1 
ATOM   4292 C  CG    . ASP A 1 532 ? 135.172 126.536 150.190 1.00 257.30 ? 532 ASP A CG    1 
ATOM   4293 O  OD1   . ASP A 1 532 ? 134.572 126.549 149.096 1.00 257.30 ? 532 ASP A OD1   1 
ATOM   4294 O  OD2   . ASP A 1 532 ? 135.269 127.542 150.925 1.00 257.30 ? 532 ASP A OD2   1 
ATOM   4295 N  N     . GLU A 1 533 ? 135.600 121.881 151.008 1.00 240.24 ? 533 GLU A N     1 
ATOM   4296 C  CA    . GLU A 1 533 ? 136.339 120.704 151.463 1.00 240.24 ? 533 GLU A CA    1 
ATOM   4297 C  C     . GLU A 1 533 ? 136.488 119.746 150.289 1.00 240.24 ? 533 GLU A C     1 
ATOM   4298 O  O     . GLU A 1 533 ? 135.543 119.049 149.915 1.00 240.24 ? 533 GLU A O     1 
ATOM   4299 C  CB    . GLU A 1 533 ? 135.627 120.046 152.638 1.00 240.24 ? 533 GLU A CB    1 
ATOM   4300 C  CG    . GLU A 1 533 ? 136.556 119.578 153.746 1.00 240.24 ? 533 GLU A CG    1 
ATOM   4301 C  CD    . GLU A 1 533 ? 135.819 118.871 154.866 1.00 240.24 ? 533 GLU A CD    1 
ATOM   4302 O  OE1   . GLU A 1 533 ? 134.686 119.285 155.189 1.00 240.24 ? 533 GLU A OE1   1 
ATOM   4303 O  OE2   . GLU A 1 533 ? 136.372 117.900 155.425 1.00 240.24 ? 533 GLU A OE2   1 
ATOM   4304 N  N     . LEU A 1 534 ? 137.685 119.713 149.700 1.00 222.17 ? 534 LEU A N     1 
ATOM   4305 C  CA    . LEU A 1 534 ? 137.908 118.869 148.531 1.00 222.17 ? 534 LEU A CA    1 
ATOM   4306 C  C     . LEU A 1 534 ? 138.060 117.402 148.919 1.00 222.17 ? 534 LEU A C     1 
ATOM   4307 O  O     . LEU A 1 534 ? 137.866 116.518 148.077 1.00 222.17 ? 534 LEU A O     1 
ATOM   4308 C  CB    . LEU A 1 534 ? 139.127 119.386 147.754 1.00 222.17 ? 534 LEU A CB    1 
ATOM   4309 C  CG    . LEU A 1 534 ? 139.873 118.581 146.683 1.00 222.17 ? 534 LEU A CG    1 
ATOM   4310 C  CD1   . LEU A 1 534 ? 140.593 119.540 145.754 1.00 222.17 ? 534 LEU A CD1   1 
ATOM   4311 C  CD2   . LEU A 1 534 ? 140.886 117.625 147.288 1.00 222.17 ? 534 LEU A CD2   1 
ATOM   4312 N  N     . LEU A 1 535 ? 138.389 117.122 150.180 1.00 192.87 ? 535 LEU A N     1 
ATOM   4313 C  CA    . LEU A 1 535 ? 138.480 115.755 150.660 1.00 192.87 ? 535 LEU A CA    1 
ATOM   4314 C  C     . LEU A 1 535 ? 137.648 115.574 151.924 1.00 192.87 ? 535 LEU A C     1 
ATOM   4315 O  O     . LEU A 1 535 ? 137.552 116.496 152.740 1.00 192.87 ? 535 LEU A O     1 
ATOM   4316 C  CB    . LEU A 1 535 ? 139.935 115.359 150.954 1.00 192.87 ? 535 LEU A CB    1 
ATOM   4317 C  CG    . LEU A 1 535 ? 140.830 115.040 149.758 1.00 192.87 ? 535 LEU A CG    1 
ATOM   4318 C  CD1   . LEU A 1 535 ? 142.266 114.826 150.207 1.00 192.87 ? 535 LEU A CD1   1 
ATOM   4319 C  CD2   . LEU A 1 535 ? 140.311 113.820 149.013 1.00 192.87 ? 535 LEU A CD2   1 
ATOM   4320 N  N     . PRO A 1 536 ? 137.034 114.403 152.111 1.00 154.95 ? 536 PRO A N     1 
ATOM   4321 C  CA    . PRO A 1 536 ? 136.297 114.162 153.347 1.00 154.95 ? 536 PRO A CA    1 
ATOM   4322 C  C     . PRO A 1 536 ? 137.251 114.003 154.516 1.00 154.95 ? 536 PRO A C     1 
ATOM   4323 O  O     . PRO A 1 536 ? 138.413 113.603 154.337 1.00 154.95 ? 536 PRO A O     1 
ATOM   4324 C  CB    . PRO A 1 536 ? 135.541 112.854 153.057 1.00 154.95 ? 536 PRO A CB    1 
ATOM   4325 C  CG    . PRO A 1 536 ? 136.386 112.161 152.050 1.00 154.95 ? 536 PRO A CG    1 
ATOM   4326 C  CD    . PRO A 1 536 ? 136.990 113.247 151.201 1.00 154.95 ? 536 PRO A CD    1 
ATOM   4327 N  N     . PRO A 1 537 ? 136.805 114.303 155.735 1.00 148.08 ? 537 PRO A N     1 
ATOM   4328 C  CA    . PRO A 1 537 ? 137.683 114.129 156.900 1.00 148.08 ? 537 PRO A CA    1 
ATOM   4329 C  C     . PRO A 1 537 ? 137.912 112.664 157.231 1.00 148.08 ? 537 PRO A C     1 
ATOM   4330 O  O     . PRO A 1 537 ? 137.403 111.775 156.543 1.00 148.08 ? 537 PRO A O     1 
ATOM   4331 C  CB    . PRO A 1 537 ? 136.922 114.848 158.020 1.00 148.08 ? 537 PRO A CB    1 
ATOM   4332 C  CG    . PRO A 1 537 ? 135.495 114.762 157.610 1.00 148.08 ? 537 PRO A CG    1 
ATOM   4333 C  CD    . PRO A 1 537 ? 135.483 114.834 156.109 1.00 148.08 ? 537 PRO A CD    1 
ATOM   4334 N  N     . TYR A 1 538 ? 138.679 112.404 158.285 1.00 161.25 ? 538 TYR A N     1 
ATOM   4335 C  CA    . TYR A 1 538 ? 139.005 111.046 158.701 1.00 161.25 ? 538 TYR A CA    1 
ATOM   4336 C  C     . TYR A 1 538 ? 138.051 110.640 159.818 1.00 161.25 ? 538 TYR A C     1 
ATOM   4337 O  O     . TYR A 1 538 ? 138.119 111.175 160.929 1.00 161.25 ? 538 TYR A O     1 
ATOM   4338 C  CB    . TYR A 1 538 ? 140.465 110.968 159.144 1.00 161.25 ? 538 TYR A CB    1 
ATOM   4339 C  CG    . TYR A 1 538 ? 140.862 109.687 159.843 1.00 161.25 ? 538 TYR A CG    1 
ATOM   4340 C  CD1   . TYR A 1 538 ? 140.982 108.496 159.140 1.00 161.25 ? 538 TYR A CD1   1 
ATOM   4341 C  CD2   . TYR A 1 538 ? 141.145 109.675 161.202 1.00 161.25 ? 538 TYR A CD2   1 
ATOM   4342 C  CE1   . TYR A 1 538 ? 141.356 107.327 159.774 1.00 161.25 ? 538 TYR A CE1   1 
ATOM   4343 C  CE2   . TYR A 1 538 ? 141.520 108.512 161.844 1.00 161.25 ? 538 TYR A CE2   1 
ATOM   4344 C  CZ    . TYR A 1 538 ? 141.623 107.342 161.126 1.00 161.25 ? 538 TYR A CZ    1 
ATOM   4345 O  OH    . TYR A 1 538 ? 141.997 106.182 161.764 1.00 161.25 ? 538 TYR A OH    1 
ATOM   4346 N  N     . MET A 1 539 ? 137.160 109.690 159.524 1.00 159.18 ? 539 MET A N     1 
ATOM   4347 C  CA    . MET A 1 539 ? 136.124 109.239 160.452 1.00 159.18 ? 539 MET A CA    1 
ATOM   4348 C  C     . MET A 1 539 ? 136.360 107.771 160.782 1.00 159.18 ? 539 MET A C     1 
ATOM   4349 O  O     . MET A 1 539 ? 135.872 106.879 160.070 1.00 159.18 ? 539 MET A O     1 
ATOM   4350 C  CB    . MET A 1 539 ? 134.731 109.442 159.863 1.00 159.18 ? 539 MET A CB    1 
ATOM   4351 C  CG    . MET A 1 539 ? 134.398 110.876 159.502 1.00 159.18 ? 539 MET A CG    1 
ATOM   4352 S  SD    . MET A 1 539 ? 133.776 111.796 160.921 1.00 159.18 ? 539 MET A SD    1 
ATOM   4353 C  CE    . MET A 1 539 ? 132.076 112.061 160.425 1.00 159.18 ? 539 MET A CE    1 
ATOM   4354 N  N     . PRO A 1 540 ? 137.098 107.472 161.853 1.00 149.43 ? 540 PRO A N     1 
ATOM   4355 C  CA    . PRO A 1 540 ? 137.307 106.061 162.206 1.00 149.43 ? 540 PRO A CA    1 
ATOM   4356 C  C     . PRO A 1 540 ? 136.085 105.411 162.827 1.00 149.43 ? 540 PRO A C     1 
ATOM   4357 O  O     . PRO A 1 540 ? 135.762 104.265 162.489 1.00 149.43 ? 540 PRO A O     1 
ATOM   4358 C  CB    . PRO A 1 540 ? 138.484 106.123 163.187 1.00 149.43 ? 540 PRO A CB    1 
ATOM   4359 C  CG    . PRO A 1 540 ? 138.377 107.474 163.807 1.00 149.43 ? 540 PRO A CG    1 
ATOM   4360 C  CD    . PRO A 1 540 ? 137.811 108.390 162.756 1.00 149.43 ? 540 PRO A CD    1 
ATOM   4361 N  N     . TYR A 1 541 ? 135.391 106.108 163.725 1.00 165.60 ? 541 TYR A N     1 
ATOM   4362 C  CA    . TYR A 1 541 ? 134.273 105.537 164.463 1.00 165.60 ? 541 TYR A CA    1 
ATOM   4363 C  C     . TYR A 1 541 ? 132.918 105.986 163.930 1.00 165.60 ? 541 TYR A C     1 
ATOM   4364 O  O     . TYR A 1 541 ? 131.894 105.710 164.563 1.00 165.60 ? 541 TYR A O     1 
ATOM   4365 C  CB    . TYR A 1 541 ? 134.392 105.887 165.947 1.00 165.60 ? 541 TYR A CB    1 
ATOM   4366 C  CG    . TYR A 1 541 ? 135.802 105.805 166.481 1.00 165.60 ? 541 TYR A CG    1 
ATOM   4367 C  CD1   . TYR A 1 541 ? 136.408 104.579 166.715 1.00 165.60 ? 541 TYR A CD1   1 
ATOM   4368 C  CD2   . TYR A 1 541 ? 136.528 106.956 166.755 1.00 165.60 ? 541 TYR A CD2   1 
ATOM   4369 C  CE1   . TYR A 1 541 ? 137.697 104.502 167.204 1.00 165.60 ? 541 TYR A CE1   1 
ATOM   4370 C  CE2   . TYR A 1 541 ? 137.816 106.889 167.244 1.00 165.60 ? 541 TYR A CE2   1 
ATOM   4371 C  CZ    . TYR A 1 541 ? 138.396 105.661 167.466 1.00 165.60 ? 541 TYR A CZ    1 
ATOM   4372 O  OH    . TYR A 1 541 ? 139.680 105.591 167.952 1.00 165.60 ? 541 TYR A OH    1 
ATOM   4373 N  N     . GLY A 1 542 ? 132.885 106.666 162.792 1.00 179.63 ? 542 GLY A N     1 
ATOM   4374 C  CA    . GLY A 1 542 ? 131.638 107.119 162.214 1.00 179.63 ? 542 GLY A CA    1 
ATOM   4375 C  C     . GLY A 1 542 ? 131.324 108.565 162.545 1.00 179.63 ? 542 GLY A C     1 
ATOM   4376 O  O     . GLY A 1 542 ? 132.203 109.389 162.806 1.00 179.63 ? 542 GLY A O     1 
ATOM   4377 N  N     . THR A 1 543 ? 130.025 108.871 162.528 1.00 160.67 ? 543 THR A N     1 
ATOM   4378 C  CA    . THR A 1 543 ? 129.584 110.242 162.770 1.00 160.67 ? 543 THR A CA    1 
ATOM   4379 C  C     . THR A 1 543 ? 129.770 110.643 164.228 1.00 160.67 ? 543 THR A C     1 
ATOM   4380 O  O     . THR A 1 543 ? 130.080 111.803 164.523 1.00 160.67 ? 543 THR A O     1 
ATOM   4381 C  CB    . THR A 1 543 ? 128.122 110.404 162.356 1.00 160.67 ? 543 THR A CB    1 
ATOM   4382 O  OG1   . THR A 1 543 ? 127.347 109.329 162.901 1.00 160.67 ? 543 THR A OG1   1 
ATOM   4383 C  CG2   . THR A 1 543 ? 127.997 110.392 160.842 1.00 160.67 ? 543 THR A CG2   1 
ATOM   4384 N  N     . ASP A 1 544 ? 129.577 109.702 165.154 1.00 197.15 ? 544 ASP A N     1 
ATOM   4385 C  CA    . ASP A 1 544 ? 129.678 110.031 166.573 1.00 197.15 ? 544 ASP A CA    1 
ATOM   4386 C  C     . ASP A 1 544 ? 131.123 110.345 166.947 1.00 197.15 ? 544 ASP A C     1 
ATOM   4387 O  O     . ASP A 1 544 ? 131.395 111.360 167.599 1.00 197.15 ? 544 ASP A O     1 
ATOM   4388 C  CB    . ASP A 1 544 ? 129.101 108.863 167.392 1.00 197.15 ? 544 ASP A CB    1 
ATOM   4389 C  CG    . ASP A 1 544 ? 129.583 108.803 168.854 1.00 197.15 ? 544 ASP A CG    1 
ATOM   4390 O  OD1   . ASP A 1 544 ? 129.189 107.835 169.534 1.00 197.15 ? 544 ASP A OD1   1 
ATOM   4391 O  OD2   . ASP A 1 544 ? 130.257 109.719 169.372 1.00 197.15 ? 544 ASP A OD2   1 
ATOM   4392 N  N     . GLY A 1 545 ? 132.062 109.509 166.511 1.00 197.64 ? 545 GLY A N     1 
ATOM   4393 C  CA    . GLY A 1 545 ? 133.439 109.609 166.937 1.00 197.64 ? 545 GLY A CA    1 
ATOM   4394 C  C     . GLY A 1 545 ? 134.131 110.871 166.464 1.00 197.64 ? 545 GLY A C     1 
ATOM   4395 O  O     . GLY A 1 545 ? 133.671 111.558 165.546 1.00 197.64 ? 545 GLY A O     1 
ATOM   4396 N  N     . PRO A 1 546 ? 135.254 111.202 167.096 1.00 164.47 ? 546 PRO A N     1 
ATOM   4397 C  CA    . PRO A 1 546 ? 135.980 112.419 166.722 1.00 164.47 ? 546 PRO A CA    1 
ATOM   4398 C  C     . PRO A 1 546 ? 136.516 112.343 165.303 1.00 164.47 ? 546 PRO A C     1 
ATOM   4399 O  O     . PRO A 1 546 ? 136.824 111.269 164.782 1.00 164.47 ? 546 PRO A O     1 
ATOM   4400 C  CB    . PRO A 1 546 ? 137.126 112.480 167.741 1.00 164.47 ? 546 PRO A CB    1 
ATOM   4401 C  CG    . PRO A 1 546 ? 136.698 111.593 168.864 1.00 164.47 ? 546 PRO A CG    1 
ATOM   4402 C  CD    . PRO A 1 546 ? 135.878 110.515 168.237 1.00 164.47 ? 546 PRO A CD    1 
ATOM   4403 N  N     . ARG A 1 547 ? 136.623 113.512 164.677 1.00 172.95 ? 547 ARG A N     1 
ATOM   4404 C  CA    . ARG A 1 547 ? 137.116 113.636 163.315 1.00 172.95 ? 547 ARG A CA    1 
ATOM   4405 C  C     . ARG A 1 547 ? 138.317 114.569 163.297 1.00 172.95 ? 547 ARG A C     1 
ATOM   4406 O  O     . ARG A 1 547 ? 138.533 115.356 164.221 1.00 172.95 ? 547 ARG A O     1 
ATOM   4407 C  CB    . ARG A 1 547 ? 136.029 114.170 162.370 1.00 172.95 ? 547 ARG A CB    1 
ATOM   4408 C  CG    . ARG A 1 547 ? 136.118 115.669 162.122 1.00 172.95 ? 547 ARG A CG    1 
ATOM   4409 C  CD    . ARG A 1 547 ? 135.017 116.175 161.207 1.00 172.95 ? 547 ARG A CD    1 
ATOM   4410 N  NE    . ARG A 1 547 ? 133.752 116.334 161.913 1.00 172.95 ? 547 ARG A NE    1 
ATOM   4411 C  CZ    . ARG A 1 547 ? 132.581 115.913 161.457 1.00 172.95 ? 547 ARG A CZ    1 
ATOM   4412 N  NH1   . ARG A 1 547 ? 132.471 115.319 160.280 1.00 172.95 ? 547 ARG A NH1   1 
ATOM   4413 N  NH2   . ARG A 1 547 ? 131.491 116.097 162.197 1.00 172.95 ? 547 ARG A NH2   1 
ATOM   4414 N  N     . VAL A 1 548 ? 139.109 114.465 162.234 1.00 158.18 ? 548 VAL A N     1 
ATOM   4415 C  CA    . VAL A 1 548 ? 140.194 115.401 161.972 1.00 158.18 ? 548 VAL A CA    1 
ATOM   4416 C  C     . VAL A 1 548 ? 140.029 115.952 160.562 1.00 158.18 ? 548 VAL A C     1 
ATOM   4417 O  O     . VAL A 1 548 ? 139.783 115.202 159.611 1.00 158.18 ? 548 VAL A O     1 
ATOM   4418 C  CB    . VAL A 1 548 ? 141.582 114.753 162.162 1.00 158.18 ? 548 VAL A CB    1 
ATOM   4419 C  CG1   . VAL A 1 548 ? 141.815 114.443 163.629 1.00 158.18 ? 548 VAL A CG1   1 
ATOM   4420 C  CG2   . VAL A 1 548 ? 141.700 113.487 161.343 1.00 158.18 ? 548 VAL A CG2   1 
ATOM   4421 N  N     . THR A 1 549 ? 140.141 117.270 160.438 1.00 173.07 ? 549 THR A N     1 
ATOM   4422 C  CA    . THR A 1 549 ? 139.952 117.978 159.184 1.00 173.07 ? 549 THR A CA    1 
ATOM   4423 C  C     . THR A 1 549 ? 141.289 118.574 158.760 1.00 173.07 ? 549 THR A C     1 
ATOM   4424 O  O     . THR A 1 549 ? 142.161 118.822 159.597 1.00 173.07 ? 549 THR A O     1 
ATOM   4425 C  CB    . THR A 1 549 ? 138.853 119.059 159.344 1.00 173.07 ? 549 THR A CB    1 
ATOM   4426 O  OG1   . THR A 1 549 ? 137.564 118.444 159.231 1.00 173.07 ? 549 THR A OG1   1 
ATOM   4427 C  CG2   . THR A 1 549 ? 138.955 120.167 158.301 1.00 173.07 ? 549 THR A CG2   1 
ATOM   4428 N  N     . MET A 1 550 ? 141.450 118.792 157.450 1.00 169.16 ? 550 MET A N     1 
ATOM   4429 C  CA    . MET A 1 550 ? 142.722 119.271 156.917 1.00 169.16 ? 550 MET A CA    1 
ATOM   4430 C  C     . MET A 1 550 ? 143.158 120.577 157.568 1.00 169.16 ? 550 MET A C     1 
ATOM   4431 O  O     . MET A 1 550 ? 144.354 120.891 157.586 1.00 169.16 ? 550 MET A O     1 
ATOM   4432 C  CB    . MET A 1 550 ? 142.616 119.461 155.405 1.00 169.16 ? 550 MET A CB    1 
ATOM   4433 C  CG    . MET A 1 550 ? 141.307 120.086 154.955 1.00 169.16 ? 550 MET A CG    1 
ATOM   4434 S  SD    . MET A 1 550 ? 139.962 118.893 154.861 1.00 169.16 ? 550 MET A SD    1 
ATOM   4435 C  CE    . MET A 1 550 ? 140.403 118.020 153.363 1.00 169.16 ? 550 MET A CE    1 
ATOM   4436 N  N     . SER A 1 551 ? 142.210 121.353 158.096 1.00 181.36 ? 551 SER A N     1 
ATOM   4437 C  CA    . SER A 1 551 ? 142.559 122.621 158.729 1.00 181.36 ? 551 SER A CA    1 
ATOM   4438 C  C     . SER A 1 551 ? 143.421 122.414 159.971 1.00 181.36 ? 551 SER A C     1 
ATOM   4439 O  O     . SER A 1 551 ? 144.393 123.147 160.185 1.00 181.36 ? 551 SER A O     1 
ATOM   4440 C  CB    . SER A 1 551 ? 141.289 123.394 159.081 1.00 181.36 ? 551 SER A CB    1 
ATOM   4441 O  OG    . SER A 1 551 ? 140.509 122.682 160.024 1.00 181.36 ? 551 SER A OG    1 
ATOM   4442 N  N     . SER A 1 552 ? 143.086 121.427 160.799 1.00 154.19 ? 552 SER A N     1 
ATOM   4443 C  CA    . SER A 1 552 ? 143.741 121.247 162.090 1.00 154.19 ? 552 SER A CA    1 
ATOM   4444 C  C     . SER A 1 552 ? 144.864 120.213 162.072 1.00 154.19 ? 552 SER A C     1 
ATOM   4445 O  O     . SER A 1 552 ? 145.518 120.017 163.103 1.00 154.19 ? 552 SER A O     1 
ATOM   4446 C  CB    . SER A 1 552 ? 142.709 120.857 163.151 1.00 154.19 ? 552 SER A CB    1 
ATOM   4447 O  OG    . SER A 1 552 ? 143.305 120.772 164.435 1.00 154.19 ? 552 SER A OG    1 
ATOM   4448 N  N     . ALA A 1 553 ? 145.106 119.553 160.938 1.00 151.08 ? 553 ALA A N     1 
ATOM   4449 C  CA    . ALA A 1 553 ? 146.102 118.486 160.905 1.00 151.08 ? 553 ALA A CA    1 
ATOM   4450 C  C     . ALA A 1 553 ? 147.514 119.023 161.117 1.00 151.08 ? 553 ALA A C     1 
ATOM   4451 O  O     . ALA A 1 553 ? 148.326 118.396 161.810 1.00 151.08 ? 553 ALA A O     1 
ATOM   4452 C  CB    . ALA A 1 553 ? 146.006 117.726 159.583 1.00 151.08 ? 553 ALA A CB    1 
ATOM   4453 N  N     . ILE A 1 554 ? 147.831 120.172 160.516 1.00 128.54 ? 554 ILE A N     1 
ATOM   4454 C  CA    . ILE A 1 554 ? 149.160 120.756 160.683 1.00 128.54 ? 554 ILE A CA    1 
ATOM   4455 C  C     . ILE A 1 554 ? 149.399 121.126 162.139 1.00 128.54 ? 554 ILE A C     1 
ATOM   4456 O  O     . ILE A 1 554 ? 150.476 120.869 162.697 1.00 128.54 ? 554 ILE A O     1 
ATOM   4457 C  CB    . ILE A 1 554 ? 149.324 121.971 159.753 1.00 128.54 ? 554 ILE A CB    1 
ATOM   4458 C  CG1   . ILE A 1 554 ? 148.900 121.608 158.329 1.00 128.54 ? 554 ILE A CG1   1 
ATOM   4459 C  CG2   . ILE A 1 554 ? 150.756 122.466 159.777 1.00 128.54 ? 554 ILE A CG2   1 
ATOM   4460 C  CD1   . ILE A 1 554 ? 148.577 122.802 157.464 1.00 128.54 ? 554 ILE A CD1   1 
ATOM   4461 N  N     . SER A 1 555 ? 148.398 121.735 162.778 1.00 151.30 ? 555 SER A N     1 
ATOM   4462 C  CA    . SER A 1 555 ? 148.511 122.056 164.196 1.00 151.30 ? 555 SER A CA    1 
ATOM   4463 C  C     . SER A 1 555 ? 148.672 120.793 165.030 1.00 151.30 ? 555 SER A C     1 
ATOM   4464 O  O     . SER A 1 555 ? 149.432 120.779 166.004 1.00 151.30 ? 555 SER A O     1 
ATOM   4465 C  CB    . SER A 1 555 ? 147.286 122.848 164.655 1.00 151.30 ? 555 SER A CB    1 
ATOM   4466 O  OG    . SER A 1 555 ? 146.154 122.006 164.781 1.00 151.30 ? 555 SER A OG    1 
ATOM   4467 N  N     . LEU A 1 556 ? 147.964 119.722 164.663 1.00 155.13 ? 556 LEU A N     1 
ATOM   4468 C  CA    . LEU A 1 556 ? 148.097 118.462 165.386 1.00 155.13 ? 556 LEU A CA    1 
ATOM   4469 C  C     . LEU A 1 556 ? 149.523 117.925 165.302 1.00 155.13 ? 556 LEU A C     1 
ATOM   4470 O  O     . LEU A 1 556 ? 150.111 117.528 166.317 1.00 155.13 ? 556 LEU A O     1 
ATOM   4471 C  CB    . LEU A 1 556 ? 147.103 117.441 164.835 1.00 155.13 ? 556 LEU A CB    1 
ATOM   4472 C  CG    . LEU A 1 556 ? 146.497 116.455 165.834 1.00 155.13 ? 556 LEU A CG    1 
ATOM   4473 C  CD1   . LEU A 1 556 ? 146.032 117.179 167.082 1.00 155.13 ? 556 LEU A CD1   1 
ATOM   4474 C  CD2   . LEU A 1 556 ? 145.350 115.694 165.197 1.00 155.13 ? 556 LEU A CD2   1 
ATOM   4475 N  N     . LEU A 1 557 ? 150.095 117.907 164.094 1.00 134.84 ? 557 LEU A N     1 
ATOM   4476 C  CA    . LEU A 1 557 ? 151.460 117.409 163.942 1.00 134.84 ? 557 LEU A CA    1 
ATOM   4477 C  C     . LEU A 1 557 ? 152.442 118.264 164.727 1.00 134.84 ? 557 LEU A C     1 
ATOM   4478 O  O     . LEU A 1 557 ? 153.340 117.741 165.396 1.00 134.84 ? 557 LEU A O     1 
ATOM   4479 C  CB    . LEU A 1 557 ? 151.879 117.371 162.474 1.00 134.84 ? 557 LEU A CB    1 
ATOM   4480 C  CG    . LEU A 1 557 ? 151.007 116.795 161.369 1.00 134.84 ? 557 LEU A CG    1 
ATOM   4481 C  CD1   . LEU A 1 557 ? 151.407 117.478 160.087 1.00 134.84 ? 557 LEU A CD1   1 
ATOM   4482 C  CD2   . LEU A 1 557 ? 151.190 115.294 161.258 1.00 134.84 ? 557 LEU A CD2   1 
ATOM   4483 N  N     . HIS A 1 558 ? 152.298 119.589 164.639 1.00 145.28 ? 558 HIS A N     1 
ATOM   4484 C  CA    . HIS A 1 558 ? 153.225 120.468 165.343 1.00 145.28 ? 558 HIS A CA    1 
ATOM   4485 C  C     . HIS A 1 558 ? 153.108 120.298 166.851 1.00 145.28 ? 558 HIS A C     1 
ATOM   4486 O  O     . HIS A 1 558 ? 154.118 120.294 167.564 1.00 145.28 ? 558 HIS A O     1 
ATOM   4487 C  CB    . HIS A 1 558 ? 152.986 121.921 164.936 1.00 145.28 ? 558 HIS A CB    1 
ATOM   4488 C  CG    . HIS A 1 558 ? 153.613 122.287 163.626 1.00 145.28 ? 558 HIS A CG    1 
ATOM   4489 N  ND1   . HIS A 1 558 ? 152.995 122.063 162.415 1.00 145.28 ? 558 HIS A ND1   1 
ATOM   4490 C  CD2   . HIS A 1 558 ? 154.807 122.856 163.340 1.00 145.28 ? 558 HIS A CD2   1 
ATOM   4491 C  CE1   . HIS A 1 558 ? 153.780 122.480 161.439 1.00 145.28 ? 558 HIS A CE1   1 
ATOM   4492 N  NE2   . HIS A 1 558 ? 154.886 122.968 161.973 1.00 145.28 ? 558 HIS A NE2   1 
ATOM   4493 N  N     . ARG A 1 559 ? 151.884 120.138 167.357 1.00 158.00 ? 559 ARG A N     1 
ATOM   4494 C  CA    . ARG A 1 559 ? 151.693 119.918 168.785 1.00 158.00 ? 559 ARG A CA    1 
ATOM   4495 C  C     . ARG A 1 559 ? 152.334 118.610 169.228 1.00 158.00 ? 559 ARG A C     1 
ATOM   4496 O  O     . ARG A 1 559 ? 153.026 118.562 170.252 1.00 158.00 ? 559 ARG A O     1 
ATOM   4497 C  CB    . ARG A 1 559 ? 150.201 119.936 169.114 1.00 158.00 ? 559 ARG A CB    1 
ATOM   4498 C  CG    . ARG A 1 559 ? 149.882 119.810 170.591 1.00 158.00 ? 559 ARG A CG    1 
ATOM   4499 C  CD    . ARG A 1 559 ? 148.396 119.561 170.951 1.00 158.00 ? 559 ARG A CD    1 
ATOM   4500 N  NE    . ARG A 1 559 ? 147.430 120.575 170.522 1.00 158.00 ? 559 ARG A NE    1 
ATOM   4501 C  CZ    . ARG A 1 559 ? 147.030 120.813 169.279 1.00 158.00 ? 559 ARG A CZ    1 
ATOM   4502 N  NH1   . ARG A 1 559 ? 147.351 120.011 168.277 1.00 158.00 ? 559 ARG A NH1   1 
ATOM   4503 N  NH2   . ARG A 1 559 ? 146.239 121.856 169.043 1.00 158.00 ? 559 ARG A NH2   1 
ATOM   4504 N  N     . TYR A 1 560 ? 152.129 117.536 168.459 1.00 168.48 ? 560 TYR A N     1 
ATOM   4505 C  CA    . TYR A 1 560 ? 152.730 116.258 168.827 1.00 168.48 ? 560 TYR A CA    1 
ATOM   4506 C  C     . TYR A 1 560 ? 154.251 116.334 168.794 1.00 168.48 ? 560 TYR A C     1 
ATOM   4507 O  O     . TYR A 1 560 ? 154.926 115.781 169.669 1.00 168.48 ? 560 TYR A O     1 
ATOM   4508 C  CB    . TYR A 1 560 ? 152.236 115.143 167.906 1.00 168.48 ? 560 TYR A CB    1 
ATOM   4509 C  CG    . TYR A 1 560 ? 152.958 113.831 168.125 1.00 168.48 ? 560 TYR A CG    1 
ATOM   4510 C  CD1   . TYR A 1 560 ? 152.912 113.191 169.356 1.00 168.48 ? 560 TYR A CD1   1 
ATOM   4511 C  CD2   . TYR A 1 560 ? 153.685 113.235 167.104 1.00 168.48 ? 560 TYR A CD2   1 
ATOM   4512 C  CE1   . TYR A 1 560 ? 153.570 111.995 169.566 1.00 168.48 ? 560 TYR A CE1   1 
ATOM   4513 C  CE2   . TYR A 1 560 ? 154.345 112.037 167.305 1.00 168.48 ? 560 TYR A CE2   1 
ATOM   4514 C  CZ    . TYR A 1 560 ? 154.284 111.422 168.537 1.00 168.48 ? 560 TYR A CZ    1 
ATOM   4515 O  OH    . TYR A 1 560 ? 154.940 110.230 168.741 1.00 168.48 ? 560 TYR A OH    1 
ATOM   4516 N  N     . CYS A 1 561 ? 154.807 117.015 167.789 1.00 173.72 ? 561 CYS A N     1 
ATOM   4517 C  CA    . CYS A 1 561 ? 156.254 117.188 167.727 1.00 173.72 ? 561 CYS A CA    1 
ATOM   4518 C  C     . CYS A 1 561 ? 156.760 117.984 168.921 1.00 173.72 ? 561 CYS A C     1 
ATOM   4519 O  O     . CYS A 1 561 ? 157.831 117.691 169.464 1.00 173.72 ? 561 CYS A O     1 
ATOM   4520 C  CB    . CYS A 1 561 ? 156.647 117.872 166.417 1.00 173.72 ? 561 CYS A CB    1 
ATOM   4521 S  SG    . CYS A 1 561 ? 156.513 116.818 164.957 1.00 173.72 ? 561 CYS A SG    1 
ATOM   4522 N  N     . SER A 1 562 ? 156.004 118.999 169.341 1.00 179.16 ? 562 SER A N     1 
ATOM   4523 C  CA    . SER A 1 562 ? 156.376 119.754 170.531 1.00 179.16 ? 562 SER A CA    1 
ATOM   4524 C  C     . SER A 1 562 ? 156.366 118.867 171.769 1.00 179.16 ? 562 SER A C     1 
ATOM   4525 O  O     . SER A 1 562 ? 157.236 118.992 172.639 1.00 179.16 ? 562 SER A O     1 
ATOM   4526 C  CB    . SER A 1 562 ? 155.435 120.943 170.716 1.00 179.16 ? 562 SER A CB    1 
ATOM   4527 O  OG    . SER A 1 562 ? 155.510 121.450 172.037 1.00 179.16 ? 562 SER A OG    1 
ATOM   4528 N  N     . LYS A 1 563 ? 155.390 117.962 171.866 1.00 195.36 ? 563 LYS A N     1 
ATOM   4529 C  CA    . LYS A 1 563 ? 155.321 117.067 173.017 1.00 195.36 ? 563 LYS A CA    1 
ATOM   4530 C  C     . LYS A 1 563 ? 156.415 116.005 173.013 1.00 195.36 ? 563 LYS A C     1 
ATOM   4531 O  O     . LYS A 1 563 ? 156.562 115.299 174.016 1.00 195.36 ? 563 LYS A O     1 
ATOM   4532 C  CB    . LYS A 1 563 ? 153.953 116.383 173.086 1.00 195.36 ? 563 LYS A CB    1 
ATOM   4533 C  CG    . LYS A 1 563 ? 152.763 117.329 173.052 1.00 195.36 ? 563 LYS A CG    1 
ATOM   4534 C  CD    . LYS A 1 563 ? 152.963 118.522 173.972 1.00 195.36 ? 563 LYS A CD    1 
ATOM   4535 C  CE    . LYS A 1 563 ? 152.016 119.657 173.613 1.00 195.36 ? 563 LYS A CE    1 
ATOM   4536 N  NZ    . LYS A 1 563 ? 152.665 120.664 172.729 1.00 195.36 ? 563 LYS A NZ    1 
ATOM   4537 N  N     . LEU A 1 564 ? 157.167 115.869 171.926 1.00 193.59 ? 564 LEU A N     1 
ATOM   4538 C  CA    . LEU A 1 564 ? 158.224 114.868 171.881 1.00 193.59 ? 564 LEU A CA    1 
ATOM   4539 C  C     . LEU A 1 564 ? 159.293 115.186 172.924 1.00 193.59 ? 564 LEU A C     1 
ATOM   4540 O  O     . LEU A 1 564 ? 159.647 116.355 173.116 1.00 193.59 ? 564 LEU A O     1 
ATOM   4541 C  CB    . LEU A 1 564 ? 158.858 114.809 170.492 1.00 193.59 ? 564 LEU A CB    1 
ATOM   4542 C  CG    . LEU A 1 564 ? 158.131 113.988 169.426 1.00 193.59 ? 564 LEU A CG    1 
ATOM   4543 C  CD1   . LEU A 1 564 ? 158.603 114.385 168.037 1.00 193.59 ? 564 LEU A CD1   1 
ATOM   4544 C  CD2   . LEU A 1 564 ? 158.340 112.502 169.665 1.00 193.59 ? 564 LEU A CD2   1 
ATOM   4545 N  N     . PRO A 1 565 ? 159.824 114.178 173.617 1.00 225.84 ? 565 PRO A N     1 
ATOM   4546 C  CA    . PRO A 1 565 ? 160.899 114.427 174.590 1.00 225.84 ? 565 PRO A CA    1 
ATOM   4547 C  C     . PRO A 1 565 ? 162.195 114.778 173.874 1.00 225.84 ? 565 PRO A C     1 
ATOM   4548 O  O     . PRO A 1 565 ? 162.736 113.974 173.112 1.00 225.84 ? 565 PRO A O     1 
ATOM   4549 C  CB    . PRO A 1 565 ? 161.007 113.099 175.346 1.00 225.84 ? 565 PRO A CB    1 
ATOM   4550 C  CG    . PRO A 1 565 ? 160.515 112.078 174.374 1.00 225.84 ? 565 PRO A CG    1 
ATOM   4551 C  CD    . PRO A 1 565 ? 159.449 112.755 173.552 1.00 225.84 ? 565 PRO A CD    1 
ATOM   4552 N  N     . SER A 1 566 ? 162.692 115.986 174.124 1.00 304.36 ? 566 SER A N     1 
ATOM   4553 C  CA    . SER A 1 566 ? 163.899 116.471 173.469 1.00 304.36 ? 566 SER A CA    1 
ATOM   4554 C  C     . SER A 1 566 ? 164.496 117.583 174.321 1.00 304.36 ? 566 SER A C     1 
ATOM   4555 O  O     . SER A 1 566 ? 164.023 117.872 175.423 1.00 304.36 ? 566 SER A O     1 
ATOM   4556 C  CB    . SER A 1 566 ? 163.601 116.950 172.045 1.00 304.36 ? 566 SER A CB    1 
ATOM   4557 O  OG    . SER A 1 566 ? 162.617 117.971 172.047 1.00 304.36 ? 566 SER A OG    1 
ATOM   4558 N  N     . ASP A 1 567 ? 165.548 118.206 173.796 1.00 371.39 ? 567 ASP A N     1 
ATOM   4559 C  CA    . ASP A 1 567 ? 166.215 119.287 174.505 1.00 371.39 ? 567 ASP A CA    1 
ATOM   4560 C  C     . ASP A 1 567 ? 165.327 120.524 174.568 1.00 371.39 ? 567 ASP A C     1 
ATOM   4561 O  O     . ASP A 1 567 ? 164.517 120.784 173.675 1.00 371.39 ? 567 ASP A O     1 
ATOM   4562 C  CB    . ASP A 1 567 ? 167.542 119.630 173.827 1.00 371.39 ? 567 ASP A CB    1 
ATOM   4563 C  CG    . ASP A 1 567 ? 168.538 118.489 173.884 1.00 371.39 ? 567 ASP A CG    1 
ATOM   4564 O  OD1   . ASP A 1 567 ? 168.314 117.541 174.665 1.00 371.39 ? 567 ASP A OD1   1 
ATOM   4565 O  OD2   . ASP A 1 567 ? 169.544 118.540 173.146 1.00 371.39 ? 567 ASP A OD2   1 
ATOM   4566 N  N     . ARG A 1 568 ? 165.484 121.287 175.651 1.00 389.73 ? 568 ARG A N     1 
ATOM   4567 C  CA    . ARG A 1 568 ? 164.710 122.512 175.818 1.00 389.73 ? 568 ARG A CA    1 
ATOM   4568 C  C     . ARG A 1 568 ? 165.110 123.565 174.791 1.00 389.73 ? 568 ARG A C     1 
ATOM   4569 O  O     . ARG A 1 568 ? 164.260 124.320 174.304 1.00 389.73 ? 568 ARG A O     1 
ATOM   4570 C  CB    . ARG A 1 568 ? 164.891 123.051 177.235 1.00 389.73 ? 568 ARG A CB    1 
ATOM   4571 C  CG    . ARG A 1 568 ? 166.302 122.878 177.774 1.00 389.73 ? 568 ARG A CG    1 
ATOM   4572 C  CD    . ARG A 1 568 ? 166.360 123.088 179.277 1.00 389.73 ? 568 ARG A CD    1 
ATOM   4573 N  NE    . ARG A 1 568 ? 167.703 122.868 179.799 1.00 389.73 ? 568 ARG A NE    1 
ATOM   4574 C  CZ    . ARG A 1 568 ? 168.213 121.676 180.077 1.00 389.73 ? 568 ARG A CZ    1 
ATOM   4575 N  NH1   . ARG A 1 568 ? 167.515 120.567 179.898 1.00 389.73 ? 568 ARG A NH1   1 
ATOM   4576 N  NH2   . ARG A 1 568 ? 169.454 121.594 180.547 1.00 389.73 ? 568 ARG A NH2   1 
ATOM   4577 N  N     . PHE A 1 569 ? 166.400 123.635 174.458 1.00 405.76 ? 569 PHE A N     1 
ATOM   4578 C  CA    . PHE A 1 569 ? 166.886 124.686 173.568 1.00 405.76 ? 569 PHE A CA    1 
ATOM   4579 C  C     . PHE A 1 569 ? 166.362 124.502 172.148 1.00 405.76 ? 569 PHE A C     1 
ATOM   4580 O  O     . PHE A 1 569 ? 165.854 125.449 171.537 1.00 405.76 ? 569 PHE A O     1 
ATOM   4581 C  CB    . PHE A 1 569 ? 168.414 124.708 173.580 1.00 405.76 ? 569 PHE A CB    1 
ATOM   4582 C  CG    . PHE A 1 569 ? 169.013 124.345 174.909 1.00 405.76 ? 569 PHE A CG    1 
ATOM   4583 C  CD1   . PHE A 1 569 ? 168.841 125.166 176.010 1.00 405.76 ? 569 PHE A CD1   1 
ATOM   4584 C  CD2   . PHE A 1 569 ? 169.745 123.177 175.058 1.00 405.76 ? 569 PHE A CD2   1 
ATOM   4585 C  CE1   . PHE A 1 569 ? 169.389 124.833 177.235 1.00 405.76 ? 569 PHE A CE1   1 
ATOM   4586 C  CE2   . PHE A 1 569 ? 170.296 122.839 176.279 1.00 405.76 ? 569 PHE A CE2   1 
ATOM   4587 C  CZ    . PHE A 1 569 ? 170.117 123.667 177.369 1.00 405.76 ? 569 PHE A CZ    1 
ATOM   4588 N  N     . THR A 1 570 ? 166.474 123.292 171.609 1.00 364.76 ? 570 THR A N     1 
ATOM   4589 C  CA    . THR A 1 570 ? 166.059 123.023 170.241 1.00 364.76 ? 570 THR A CA    1 
ATOM   4590 C  C     . THR A 1 570 ? 164.608 122.561 170.197 1.00 364.76 ? 570 THR A C     1 
ATOM   4591 O  O     . THR A 1 570 ? 164.083 121.993 171.158 1.00 364.76 ? 570 THR A O     1 
ATOM   4592 C  CB    . THR A 1 570 ? 166.960 121.968 169.595 1.00 364.76 ? 570 THR A CB    1 
ATOM   4593 O  OG1   . THR A 1 570 ? 166.553 121.754 168.237 1.00 364.76 ? 570 THR A OG1   1 
ATOM   4594 C  CG2   . THR A 1 570 ? 166.881 120.652 170.355 1.00 364.76 ? 570 THR A CG2   1 
ATOM   4595 N  N     . THR A 1 571 ? 163.958 122.825 169.067 1.00 286.91 ? 571 THR A N     1 
ATOM   4596 C  CA    . THR A 1 571 ? 162.583 122.412 168.826 1.00 286.91 ? 571 THR A CA    1 
ATOM   4597 C  C     . THR A 1 571 ? 162.544 121.490 167.615 1.00 286.91 ? 571 THR A C     1 
ATOM   4598 O  O     . THR A 1 571 ? 163.094 121.821 166.560 1.00 286.91 ? 571 THR A O     1 
ATOM   4599 C  CB    . THR A 1 571 ? 161.672 123.620 168.596 1.00 286.91 ? 571 THR A CB    1 
ATOM   4600 O  OG1   . THR A 1 571 ? 161.829 124.091 167.252 1.00 286.91 ? 571 THR A OG1   1 
ATOM   4601 C  CG2   . THR A 1 571 ? 162.012 124.742 169.565 1.00 286.91 ? 571 THR A CG2   1 
ATOM   4602 N  N     . LEU A 1 572 ? 161.897 120.339 167.770 1.00 223.16 ? 572 LEU A N     1 
ATOM   4603 C  CA    . LEU A 1 572 ? 161.771 119.385 166.676 1.00 223.16 ? 572 LEU A CA    1 
ATOM   4604 C  C     . LEU A 1 572 ? 160.693 119.865 165.713 1.00 223.16 ? 572 LEU A C     1 
ATOM   4605 O  O     . LEU A 1 572 ? 159.511 119.912 166.068 1.00 223.16 ? 572 LEU A O     1 
ATOM   4606 C  CB    . LEU A 1 572 ? 161.437 117.997 167.216 1.00 223.16 ? 572 LEU A CB    1 
ATOM   4607 C  CG    . LEU A 1 572 ? 162.582 117.218 167.864 1.00 223.16 ? 572 LEU A CG    1 
ATOM   4608 C  CD1   . LEU A 1 572 ? 162.219 115.748 168.003 1.00 223.16 ? 572 LEU A CD1   1 
ATOM   4609 C  CD2   . LEU A 1 572 ? 163.865 117.384 167.067 1.00 223.16 ? 572 LEU A CD2   1 
ATOM   4610 N  N     . THR A 1 573 ? 161.099 120.221 164.497 1.00 181.33 ? 573 THR A N     1 
ATOM   4611 C  CA    . THR A 1 573 ? 160.170 120.691 163.486 1.00 181.33 ? 573 THR A CA    1 
ATOM   4612 C  C     . THR A 1 573 ? 160.258 119.804 162.252 1.00 181.33 ? 573 THR A C     1 
ATOM   4613 O  O     . THR A 1 573 ? 161.361 119.481 161.795 1.00 181.33 ? 573 THR A O     1 
ATOM   4614 C  CB    . THR A 1 573 ? 160.455 122.145 163.086 1.00 181.33 ? 573 THR A CB    1 
ATOM   4615 O  OG1   . THR A 1 573 ? 161.400 122.168 162.009 1.00 181.33 ? 573 THR A OG1   1 
ATOM   4616 C  CG2   . THR A 1 573 ? 161.017 122.928 164.262 1.00 181.33 ? 573 THR A CG2   1 
ATOM   4617 N  N     . PRO A 1 574 ? 159.120 119.388 161.702 1.00 145.58 ? 574 PRO A N     1 
ATOM   4618 C  CA    . PRO A 1 574 ? 159.149 118.593 160.470 1.00 145.58 ? 574 PRO A CA    1 
ATOM   4619 C  C     . PRO A 1 574 ? 159.754 119.380 159.319 1.00 145.58 ? 574 PRO A C     1 
ATOM   4620 O  O     . PRO A 1 574 ? 159.552 120.589 159.188 1.00 145.58 ? 574 PRO A O     1 
ATOM   4621 C  CB    . PRO A 1 574 ? 157.671 118.274 160.215 1.00 145.58 ? 574 PRO A CB    1 
ATOM   4622 C  CG    . PRO A 1 574 ? 156.910 119.292 160.999 1.00 145.58 ? 574 PRO A CG    1 
ATOM   4623 C  CD    . PRO A 1 574 ? 157.751 119.618 162.190 1.00 145.58 ? 574 PRO A CD    1 
ATOM   4624 N  N     . LYS A 1 575 ? 160.500 118.676 158.477 1.00 144.96 ? 575 LYS A N     1 
ATOM   4625 C  CA    . LYS A 1 575 ? 161.105 119.260 157.290 1.00 144.96 ? 575 LYS A CA    1 
ATOM   4626 C  C     . LYS A 1 575 ? 160.179 119.030 156.105 1.00 144.96 ? 575 LYS A C     1 
ATOM   4627 O  O     . LYS A 1 575 ? 159.758 117.896 155.851 1.00 144.96 ? 575 LYS A O     1 
ATOM   4628 C  CB    . LYS A 1 575 ? 162.480 118.651 157.020 1.00 144.96 ? 575 LYS A CB    1 
ATOM   4629 C  CG    . LYS A 1 575 ? 163.433 118.743 158.199 1.00 144.96 ? 575 LYS A CG    1 
ATOM   4630 C  CD    . LYS A 1 575 ? 164.835 118.313 157.807 1.00 144.96 ? 575 LYS A CD    1 
ATOM   4631 C  CE    . LYS A 1 575 ? 165.479 119.331 156.881 1.00 144.96 ? 575 LYS A CE    1 
ATOM   4632 N  NZ    . LYS A 1 575 ? 165.722 120.628 157.571 1.00 144.96 ? 575 LYS A NZ    1 
ATOM   4633 N  N     . PHE A 1 576 ? 159.865 120.100 155.386 1.00 127.76 ? 576 PHE A N     1 
ATOM   4634 C  CA    . PHE A 1 576 ? 158.857 120.068 154.337 1.00 127.76 ? 576 PHE A CA    1 
ATOM   4635 C  C     . PHE A 1 576 ? 159.524 120.177 152.975 1.00 127.76 ? 576 PHE A C     1 
ATOM   4636 O  O     . PHE A 1 576 ? 160.229 121.153 152.699 1.00 127.76 ? 576 PHE A O     1 
ATOM   4637 C  CB    . PHE A 1 576 ? 157.844 121.195 154.534 1.00 127.76 ? 576 PHE A CB    1 
ATOM   4638 C  CG    . PHE A 1 576 ? 156.869 120.937 155.644 1.00 127.76 ? 576 PHE A CG    1 
ATOM   4639 C  CD1   . PHE A 1 576 ? 155.641 120.353 155.387 1.00 127.76 ? 576 PHE A CD1   1 
ATOM   4640 C  CD2   . PHE A 1 576 ? 157.194 121.257 156.951 1.00 127.76 ? 576 PHE A CD2   1 
ATOM   4641 C  CE1   . PHE A 1 576 ? 154.748 120.108 156.413 1.00 127.76 ? 576 PHE A CE1   1 
ATOM   4642 C  CE2   . PHE A 1 576 ? 156.306 121.014 157.980 1.00 127.76 ? 576 PHE A CE2   1 
ATOM   4643 C  CZ    . PHE A 1 576 ? 155.082 120.439 157.711 1.00 127.76 ? 576 PHE A CZ    1 
ATOM   4644 N  N     . THR A 1 577 ? 159.294 119.177 152.130 1.00 129.82 ? 577 THR A N     1 
ATOM   4645 C  CA    . THR A 1 577 ? 159.830 119.138 150.778 1.00 129.82 ? 577 THR A CA    1 
ATOM   4646 C  C     . THR A 1 577 ? 158.674 119.213 149.795 1.00 129.82 ? 577 THR A C     1 
ATOM   4647 O  O     . THR A 1 577 ? 157.684 118.489 149.940 1.00 129.82 ? 577 THR A O     1 
ATOM   4648 C  CB    . THR A 1 577 ? 160.647 117.866 150.544 1.00 129.82 ? 577 THR A CB    1 
ATOM   4649 O  OG1   . THR A 1 577 ? 161.739 117.821 151.470 1.00 129.82 ? 577 THR A OG1   1 
ATOM   4650 C  CG2   . THR A 1 577 ? 161.190 117.835 149.124 1.00 129.82 ? 577 THR A CG2   1 
ATOM   4651 N  N     . TYR A 1 578 ? 158.799 120.082 148.799 1.00 144.72 ? 578 TYR A N     1 
ATOM   4652 C  CA    . TYR A 1 578 ? 157.727 120.350 147.853 1.00 144.72 ? 578 TYR A CA    1 
ATOM   4653 C  C     . TYR A 1 578 ? 158.124 119.850 146.473 1.00 144.72 ? 578 TYR A C     1 
ATOM   4654 O  O     . TYR A 1 578 ? 159.255 120.071 146.028 1.00 144.72 ? 578 TYR A O     1 
ATOM   4655 C  CB    . TYR A 1 578 ? 157.407 121.844 147.810 1.00 144.72 ? 578 TYR A CB    1 
ATOM   4656 C  CG    . TYR A 1 578 ? 157.031 122.409 149.161 1.00 144.72 ? 578 TYR A CG    1 
ATOM   4657 C  CD1   . TYR A 1 578 ? 156.259 121.674 150.050 1.00 144.72 ? 578 TYR A CD1   1 
ATOM   4658 C  CD2   . TYR A 1 578 ? 157.452 123.673 149.550 1.00 144.72 ? 578 TYR A CD2   1 
ATOM   4659 C  CE1   . TYR A 1 578 ? 155.913 122.182 151.285 1.00 144.72 ? 578 TYR A CE1   1 
ATOM   4660 C  CE2   . TYR A 1 578 ? 157.110 124.191 150.784 1.00 144.72 ? 578 TYR A CE2   1 
ATOM   4661 C  CZ    . TYR A 1 578 ? 156.340 123.440 151.647 1.00 144.72 ? 578 TYR A CZ    1 
ATOM   4662 O  OH    . TYR A 1 578 ? 155.998 123.949 152.878 1.00 144.72 ? 578 TYR A OH    1 
ATOM   4663 N  N     . ILE A 1 579 ? 157.193 119.175 145.803 1.00 171.26 ? 579 ILE A N     1 
ATOM   4664 C  CA    . ILE A 1 579 ? 157.411 118.621 144.474 1.00 171.26 ? 579 ILE A CA    1 
ATOM   4665 C  C     . ILE A 1 579 ? 156.396 119.240 143.525 1.00 171.26 ? 579 ILE A C     1 
ATOM   4666 O  O     . ILE A 1 579 ? 155.191 119.222 143.799 1.00 171.26 ? 579 ILE A O     1 
ATOM   4667 C  CB    . ILE A 1 579 ? 157.294 117.085 144.471 1.00 171.26 ? 579 ILE A CB    1 
ATOM   4668 C  CG1   . ILE A 1 579 ? 158.235 116.477 145.513 1.00 171.26 ? 579 ILE A CG1   1 
ATOM   4669 C  CG2   . ILE A 1 579 ? 157.591 116.532 143.087 1.00 171.26 ? 579 ILE A CG2   1 
ATOM   4670 C  CD1   . ILE A 1 579 ? 159.688 116.839 145.308 1.00 171.26 ? 579 ILE A CD1   1 
ATOM   4671 N  N     . GLU A 1 580 ? 156.884 119.784 142.416 1.00 216.02 ? 580 GLU A N     1 
ATOM   4672 C  CA    . GLU A 1 580 ? 156.045 120.406 141.402 1.00 216.02 ? 580 GLU A CA    1 
ATOM   4673 C  C     . GLU A 1 580 ? 155.980 119.499 140.184 1.00 216.02 ? 580 GLU A C     1 
ATOM   4674 O  O     . GLU A 1 580 ? 157.003 118.956 139.753 1.00 216.02 ? 580 GLU A O     1 
ATOM   4675 C  CB    . GLU A 1 580 ? 156.584 121.784 141.012 1.00 216.02 ? 580 GLU A CB    1 
ATOM   4676 C  CG    . GLU A 1 580 ? 155.637 122.610 140.151 1.00 216.02 ? 580 GLU A CG    1 
ATOM   4677 C  CD    . GLU A 1 580 ? 155.754 122.295 138.672 1.00 216.02 ? 580 GLU A CD    1 
ATOM   4678 O  OE1   . GLU A 1 580 ? 156.845 121.869 138.236 1.00 216.02 ? 580 GLU A OE1   1 
ATOM   4679 O  OE2   . GLU A 1 580 ? 154.753 122.471 137.945 1.00 216.02 ? 580 GLU A OE2   1 
ATOM   4680 N  N     . GLN A 1 581 ? 154.780 119.334 139.634 1.00 229.64 ? 581 GLN A N     1 
ATOM   4681 C  CA    . GLN A 1 581 ? 154.587 118.500 138.458 1.00 229.64 ? 581 GLN A CA    1 
ATOM   4682 C  C     . GLN A 1 581 ? 153.435 119.053 137.635 1.00 229.64 ? 581 GLN A C     1 
ATOM   4683 O  O     . GLN A 1 581 ? 152.554 119.742 138.158 1.00 229.64 ? 581 GLN A O     1 
ATOM   4684 C  CB    . GLN A 1 581 ? 154.315 117.039 138.841 1.00 229.64 ? 581 GLN A CB    1 
ATOM   4685 C  CG    . GLN A 1 581 ? 152.979 116.814 139.535 1.00 229.64 ? 581 GLN A CG    1 
ATOM   4686 C  CD    . GLN A 1 581 ? 153.013 117.177 141.008 1.00 229.64 ? 581 GLN A CD    1 
ATOM   4687 O  OE1   . GLN A 1 581 ? 154.056 117.548 141.545 1.00 229.64 ? 581 GLN A OE1   1 
ATOM   4688 N  NE2   . GLN A 1 581 ? 151.865 117.075 141.668 1.00 229.64 ? 581 GLN A NE2   1 
ATOM   4689 N  N     . ASN A 1 582 ? 153.454 118.750 136.341 1.00 276.41 ? 582 ASN A N     1 
ATOM   4690 C  CA    . ASN A 1 582 ? 152.396 119.138 135.421 1.00 276.41 ? 582 ASN A CA    1 
ATOM   4691 C  C     . ASN A 1 582 ? 151.821 117.889 134.773 1.00 276.41 ? 582 ASN A C     1 
ATOM   4692 O  O     . ASN A 1 582 ? 152.568 117.063 134.236 1.00 276.41 ? 582 ASN A O     1 
ATOM   4693 C  CB    . ASN A 1 582 ? 152.917 120.102 134.350 1.00 276.41 ? 582 ASN A CB    1 
ATOM   4694 C  CG    . ASN A 1 582 ? 153.070 121.519 134.868 1.00 276.41 ? 582 ASN A CG    1 
ATOM   4695 O  OD1   . ASN A 1 582 ? 154.177 121.967 135.165 1.00 276.41 ? 582 ASN A OD1   1 
ATOM   4696 N  ND2   . ASN A 1 582 ? 151.957 122.232 134.977 1.00 276.41 ? 582 ASN A ND2   1 
ATOM   4697 N  N     . ASN A 1 583 ? 150.500 117.753 134.824 1.00 287.89 ? 583 ASN A N     1 
ATOM   4698 C  CA    . ASN A 1 583 ? 149.826 116.602 134.247 1.00 287.89 ? 583 ASN A CA    1 
ATOM   4699 C  C     . ASN A 1 583 ? 149.775 116.727 132.725 1.00 287.89 ? 583 ASN A C     1 
ATOM   4700 O  O     . ASN A 1 583 ? 150.327 117.656 132.129 1.00 287.89 ? 583 ASN A O     1 
ATOM   4701 C  CB    . ASN A 1 583 ? 148.423 116.465 134.831 1.00 287.89 ? 583 ASN A CB    1 
ATOM   4702 C  CG    . ASN A 1 583 ? 147.704 117.795 134.941 1.00 287.89 ? 583 ASN A CG    1 
ATOM   4703 O  OD1   . ASN A 1 583 ? 147.955 118.716 134.163 1.00 287.89 ? 583 ASN A OD1   1 
ATOM   4704 N  ND2   . ASN A 1 583 ? 146.802 117.902 135.909 1.00 287.89 ? 583 ASN A ND2   1 
ATOM   4705 N  N     . GLU A 1 584 ? 149.103 115.768 132.084 1.00 312.46 ? 584 GLU A N     1 
ATOM   4706 C  CA    . GLU A 1 584 ? 148.871 115.864 130.648 1.00 312.46 ? 584 GLU A CA    1 
ATOM   4707 C  C     . GLU A 1 584 ? 148.011 117.068 130.293 1.00 312.46 ? 584 GLU A C     1 
ATOM   4708 O  O     . GLU A 1 584 ? 148.097 117.566 129.166 1.00 312.46 ? 584 GLU A O     1 
ATOM   4709 C  CB    . GLU A 1 584 ? 148.226 114.575 130.128 1.00 312.46 ? 584 GLU A CB    1 
ATOM   4710 C  CG    . GLU A 1 584 ? 146.719 114.490 130.321 1.00 312.46 ? 584 GLU A CG    1 
ATOM   4711 C  CD    . GLU A 1 584 ? 146.314 114.379 131.779 1.00 312.46 ? 584 GLU A CD    1 
ATOM   4712 O  OE1   . GLU A 1 584 ? 147.167 114.004 132.612 1.00 312.46 ? 584 GLU A OE1   1 
ATOM   4713 O  OE2   . GLU A 1 584 ? 145.141 114.667 132.094 1.00 312.46 ? 584 GLU A OE2   1 
ATOM   4714 N  N     . GLU A 1 585 ? 147.186 117.545 131.229 1.00 319.52 ? 585 GLU A N     1 
ATOM   4715 C  CA    . GLU A 1 585 ? 146.462 118.795 131.048 1.00 319.52 ? 585 GLU A CA    1 
ATOM   4716 C  C     . GLU A 1 585 ? 147.366 120.012 131.184 1.00 319.52 ? 585 GLU A C     1 
ATOM   4717 O  O     . GLU A 1 585 ? 146.920 121.129 130.898 1.00 319.52 ? 585 GLU A O     1 
ATOM   4718 C  CB    . GLU A 1 585 ? 145.315 118.885 132.057 1.00 319.52 ? 585 GLU A CB    1 
ATOM   4719 C  CG    . GLU A 1 585 ? 144.103 119.659 131.563 1.00 319.52 ? 585 GLU A CG    1 
ATOM   4720 C  CD    . GLU A 1 585 ? 143.623 119.188 130.206 1.00 319.52 ? 585 GLU A CD    1 
ATOM   4721 O  OE1   . GLU A 1 585 ? 143.444 117.963 130.030 1.00 319.52 ? 585 GLU A OE1   1 
ATOM   4722 O  OE2   . GLU A 1 585 ? 143.423 120.040 129.316 1.00 319.52 ? 585 GLU A OE2   1 
ATOM   4723 N  N     . GLU A 1 586 ? 148.608 119.821 131.627 1.00 316.52 ? 586 GLU A N     1 
ATOM   4724 C  CA    . GLU A 1 586 ? 149.621 120.858 131.800 1.00 316.52 ? 586 GLU A CA    1 
ATOM   4725 C  C     . GLU A 1 586 ? 149.241 121.888 132.855 1.00 316.52 ? 586 GLU A C     1 
ATOM   4726 O  O     . GLU A 1 586 ? 149.850 122.964 132.907 1.00 316.52 ? 586 GLU A O     1 
ATOM   4727 C  CB    . GLU A 1 586 ? 149.942 121.568 130.480 1.00 316.52 ? 586 GLU A CB    1 
ATOM   4728 C  CG    . GLU A 1 586 ? 150.486 120.640 129.406 1.00 316.52 ? 586 GLU A CG    1 
ATOM   4729 C  CD    . GLU A 1 586 ? 151.729 119.896 129.856 1.00 316.52 ? 586 GLU A CD    1 
ATOM   4730 O  OE1   . GLU A 1 586 ? 152.609 120.525 130.478 1.00 316.52 ? 586 GLU A OE1   1 
ATOM   4731 O  OE2   . GLU A 1 586 ? 151.823 118.679 129.588 1.00 316.52 ? 586 GLU A OE2   1 
ATOM   4732 N  N     . ASN A 1 587 ? 148.255 121.593 133.697 1.00 294.23 ? 587 ASN A N     1 
ATOM   4733 C  CA    . ASN A 1 587 ? 147.926 122.484 134.796 1.00 294.23 ? 587 ASN A CA    1 
ATOM   4734 C  C     . ASN A 1 587 ? 148.977 122.372 135.897 1.00 294.23 ? 587 ASN A C     1 
ATOM   4735 O  O     . ASN A 1 587 ? 149.754 121.414 135.960 1.00 294.23 ? 587 ASN A O     1 
ATOM   4736 C  CB    . ASN A 1 587 ? 146.538 122.167 135.351 1.00 294.23 ? 587 ASN A CB    1 
ATOM   4737 C  CG    . ASN A 1 587 ? 145.431 122.487 134.366 1.00 294.23 ? 587 ASN A CG    1 
ATOM   4738 O  OD1   . ASN A 1 587 ? 144.520 121.686 134.156 1.00 294.23 ? 587 ASN A OD1   1 
ATOM   4739 N  ND2   . ASN A 1 587 ? 145.503 123.664 133.756 1.00 294.23 ? 587 ASN A ND2   1 
ATOM   4740 N  N     . LYS A 1 588 ? 148.998 123.373 136.771 1.00 236.39 ? 588 LYS A N     1 
ATOM   4741 C  CA    . LYS A 1 588 ? 149.995 123.447 137.837 1.00 236.39 ? 588 LYS A CA    1 
ATOM   4742 C  C     . LYS A 1 588 ? 149.549 122.560 138.993 1.00 236.39 ? 588 LYS A C     1 
ATOM   4743 O  O     . LYS A 1 588 ? 148.727 122.961 139.817 1.00 236.39 ? 588 LYS A O     1 
ATOM   4744 C  CB    . LYS A 1 588 ? 150.185 124.891 138.285 1.00 236.39 ? 588 LYS A CB    1 
ATOM   4745 C  CG    . LYS A 1 588 ? 151.198 125.073 139.400 1.00 236.39 ? 588 LYS A CG    1 
ATOM   4746 C  CD    . LYS A 1 588 ? 151.559 126.538 139.574 1.00 236.39 ? 588 LYS A CD    1 
ATOM   4747 C  CE    . LYS A 1 588 ? 150.387 127.335 140.122 1.00 236.39 ? 588 LYS A CE    1 
ATOM   4748 N  NZ    . LYS A 1 588 ? 150.775 128.732 140.461 1.00 236.39 ? 588 LYS A NZ    1 
ATOM   4749 N  N     . MET A 1 589 ? 150.092 121.346 139.054 1.00 227.33 ? 589 MET A N     1 
ATOM   4750 C  CA    . MET A 1 589 ? 149.831 120.416 140.144 1.00 227.33 ? 589 MET A CA    1 
ATOM   4751 C  C     . MET A 1 589 ? 150.936 120.507 141.187 1.00 227.33 ? 589 MET A C     1 
ATOM   4752 O  O     . MET A 1 589 ? 152.120 120.584 140.848 1.00 227.33 ? 589 MET A O     1 
ATOM   4753 C  CB    . MET A 1 589 ? 149.723 118.975 139.636 1.00 227.33 ? 589 MET A CB    1 
ATOM   4754 C  CG    . MET A 1 589 ? 148.885 118.753 138.374 1.00 227.33 ? 589 MET A CG    1 
ATOM   4755 S  SD    . MET A 1 589 ? 147.662 120.010 137.938 1.00 227.33 ? 589 MET A SD    1 
ATOM   4756 C  CE    . MET A 1 589 ? 146.529 119.941 139.328 1.00 227.33 ? 589 MET A CE    1 
ATOM   4757 N  N     . PHE A 1 590 ? 150.543 120.493 142.458 1.00 188.83 ? 590 PHE A N     1 
ATOM   4758 C  CA    . PHE A 1 590 ? 151.474 120.549 143.574 1.00 188.83 ? 590 PHE A CA    1 
ATOM   4759 C  C     . PHE A 1 590 ? 151.309 119.316 144.449 1.00 188.83 ? 590 PHE A C     1 
ATOM   4760 O  O     . PHE A 1 590 ? 150.186 118.871 144.705 1.00 188.83 ? 590 PHE A O     1 
ATOM   4761 C  CB    . PHE A 1 590 ? 151.260 121.811 144.415 1.00 188.83 ? 590 PHE A CB    1 
ATOM   4762 C  CG    . PHE A 1 590 ? 151.826 123.056 143.797 1.00 188.83 ? 590 PHE A CG    1 
ATOM   4763 C  CD1   . PHE A 1 590 ? 152.746 122.978 142.766 1.00 188.83 ? 590 PHE A CD1   1 
ATOM   4764 C  CD2   . PHE A 1 590 ? 151.445 124.305 144.254 1.00 188.83 ? 590 PHE A CD2   1 
ATOM   4765 C  CE1   . PHE A 1 590 ? 153.268 124.124 142.200 1.00 188.83 ? 590 PHE A CE1   1 
ATOM   4766 C  CE2   . PHE A 1 590 ? 151.964 125.453 143.692 1.00 188.83 ? 590 PHE A CE2   1 
ATOM   4767 C  CZ    . PHE A 1 590 ? 152.877 125.363 142.664 1.00 188.83 ? 590 PHE A CZ    1 
ATOM   4768 N  N     . ARG A 1 591 ? 152.434 118.766 144.900 1.00 182.27 ? 591 ARG A N     1 
ATOM   4769 C  CA    . ARG A 1 591 ? 152.442 117.634 145.813 1.00 182.27 ? 591 ARG A CA    1 
ATOM   4770 C  C     . ARG A 1 591 ? 153.545 117.838 146.839 1.00 182.27 ? 591 ARG A C     1 
ATOM   4771 O  O     . ARG A 1 591 ? 154.655 118.251 146.492 1.00 182.27 ? 591 ARG A O     1 
ATOM   4772 C  CB    . ARG A 1 591 ? 152.647 116.308 145.069 1.00 182.27 ? 591 ARG A CB    1 
ATOM   4773 C  CG    . ARG A 1 591 ? 152.536 115.078 145.951 1.00 182.27 ? 591 ARG A CG    1 
ATOM   4774 C  CD    . ARG A 1 591 ? 152.502 113.802 145.126 1.00 182.27 ? 591 ARG A CD    1 
ATOM   4775 N  NE    . ARG A 1 591 ? 153.745 113.584 144.396 1.00 182.27 ? 591 ARG A NE    1 
ATOM   4776 C  CZ    . ARG A 1 591 ? 153.878 113.731 143.085 1.00 182.27 ? 591 ARG A CZ    1 
ATOM   4777 N  NH1   . ARG A 1 591 ? 152.861 114.097 142.324 1.00 182.27 ? 591 ARG A NH1   1 
ATOM   4778 N  NH2   . ARG A 1 591 ? 155.063 113.504 142.524 1.00 182.27 ? 591 ARG A NH2   1 
ATOM   4779 N  N     . CYS A 1 592 ? 153.237 117.549 148.098 1.00 156.74 ? 592 CYS A N     1 
ATOM   4780 C  CA    . CYS A 1 592 ? 154.156 117.782 149.201 1.00 156.74 ? 592 CYS A CA    1 
ATOM   4781 C  C     . CYS A 1 592 ? 154.661 116.465 149.773 1.00 156.74 ? 592 CYS A C     1 
ATOM   4782 O  O     . CYS A 1 592 ? 154.097 115.396 149.521 1.00 156.74 ? 592 CYS A O     1 
ATOM   4783 C  CB    . CYS A 1 592 ? 153.488 118.599 150.312 1.00 156.74 ? 592 CYS A CB    1 
ATOM   4784 S  SG    . CYS A 1 592 ? 154.239 118.381 151.942 1.00 156.74 ? 592 CYS A SG    1 
ATOM   4785 N  N     . THR A 1 593 ? 155.741 116.560 150.544 1.00 138.99 ? 593 THR A N     1 
ATOM   4786 C  CA    . THR A 1 593 ? 156.335 115.424 151.231 1.00 138.99 ? 593 THR A CA    1 
ATOM   4787 C  C     . THR A 1 593 ? 157.097 115.949 152.437 1.00 138.99 ? 593 THR A C     1 
ATOM   4788 O  O     . THR A 1 593 ? 157.752 116.991 152.357 1.00 138.99 ? 593 THR A O     1 
ATOM   4789 C  CB    . THR A 1 593 ? 157.276 114.631 150.313 1.00 138.99 ? 593 THR A CB    1 
ATOM   4790 O  OG1   . THR A 1 593 ? 156.606 114.324 149.084 1.00 138.99 ? 593 THR A OG1   1 
ATOM   4791 C  CG2   . THR A 1 593 ? 157.714 113.337 150.981 1.00 138.99 ? 593 THR A CG2   1 
ATOM   4792 N  N     . LEU A 1 594 ? 157.012 115.228 153.551 1.00 119.41 ? 594 LEU A N     1 
ATOM   4793 C  CA    . LEU A 1 594 ? 157.614 115.671 154.797 1.00 119.41 ? 594 LEU A CA    1 
ATOM   4794 C  C     . LEU A 1 594 ? 158.357 114.517 155.451 1.00 119.41 ? 594 LEU A C     1 
ATOM   4795 O  O     . LEU A 1 594 ? 158.110 113.345 155.160 1.00 119.41 ? 594 LEU A O     1 
ATOM   4796 C  CB    . LEU A 1 594 ? 156.552 116.249 155.751 1.00 119.41 ? 594 LEU A CB    1 
ATOM   4797 C  CG    . LEU A 1 594 ? 155.741 115.336 156.676 1.00 119.41 ? 594 LEU A CG    1 
ATOM   4798 C  CD1   . LEU A 1 594 ? 156.444 115.102 158.007 1.00 119.41 ? 594 LEU A CD1   1 
ATOM   4799 C  CD2   . LEU A 1 594 ? 154.349 115.906 156.900 1.00 119.41 ? 594 LEU A CD2   1 
ATOM   4800 N  N     . ARG A 1 595 ? 159.278 114.868 156.342 1.00 131.71 ? 595 ARG A N     1 
ATOM   4801 C  CA    . ARG A 1 595 ? 160.044 113.895 157.105 1.00 131.71 ? 595 ARG A CA    1 
ATOM   4802 C  C     . ARG A 1 595 ? 159.948 114.222 158.586 1.00 131.71 ? 595 ARG A C     1 
ATOM   4803 O  O     . ARG A 1 595 ? 160.165 115.365 158.995 1.00 131.71 ? 595 ARG A O     1 
ATOM   4804 C  CB    . ARG A 1 595 ? 161.512 113.872 156.671 1.00 131.71 ? 595 ARG A CB    1 
ATOM   4805 C  CG    . ARG A 1 595 ? 161.744 113.280 155.295 1.00 131.71 ? 595 ARG A CG    1 
ATOM   4806 C  CD    . ARG A 1 595 ? 163.215 113.330 154.917 1.00 131.71 ? 595 ARG A CD    1 
ATOM   4807 N  NE    . ARG A 1 595 ? 163.447 112.837 153.565 1.00 131.71 ? 595 ARG A NE    1 
ATOM   4808 C  CZ    . ARG A 1 595 ? 163.297 113.564 152.466 1.00 131.71 ? 595 ARG A CZ    1 
ATOM   4809 N  NH1   . ARG A 1 595 ? 162.917 114.830 152.522 1.00 131.71 ? 595 ARG A NH1   1 
ATOM   4810 N  NH2   . ARG A 1 595 ? 163.536 113.008 151.282 1.00 131.71 ? 595 ARG A NH2   1 
ATOM   4811 N  N     . LEU A 1 596 ? 159.624 113.213 159.380 1.00 142.53 ? 596 LEU A N     1 
ATOM   4812 C  CA    . LEU A 1 596 ? 159.543 113.360 160.820 1.00 142.53 ? 596 LEU A CA    1 
ATOM   4813 C  C     . LEU A 1 596 ? 160.950 113.440 161.411 1.00 142.53 ? 596 LEU A C     1 
ATOM   4814 O  O     . LEU A 1 596 ? 161.913 112.958 160.810 1.00 142.53 ? 596 LEU A O     1 
ATOM   4815 C  CB    . LEU A 1 596 ? 158.785 112.177 161.416 1.00 142.53 ? 596 LEU A CB    1 
ATOM   4816 C  CG    . LEU A 1 596 ? 157.338 112.323 161.911 1.00 142.53 ? 596 LEU A CG    1 
ATOM   4817 C  CD1   . LEU A 1 596 ? 157.220 113.128 163.197 1.00 142.53 ? 596 LEU A CD1   1 
ATOM   4818 C  CD2   . LEU A 1 596 ? 156.458 112.918 160.826 1.00 142.53 ? 596 LEU A CD2   1 
ATOM   4819 N  N     . PRO A 1 597 ? 161.101 114.053 162.588 1.00 159.73 ? 597 PRO A N     1 
ATOM   4820 C  CA    . PRO A 1 597 ? 162.418 114.070 163.240 1.00 159.73 ? 597 PRO A CA    1 
ATOM   4821 C  C     . PRO A 1 597 ? 162.855 112.702 163.742 1.00 159.73 ? 597 PRO A C     1 
ATOM   4822 O  O     . PRO A 1 597 ? 162.167 111.699 163.528 1.00 159.73 ? 597 PRO A O     1 
ATOM   4823 C  CB    . PRO A 1 597 ? 162.224 115.057 164.399 1.00 159.73 ? 597 PRO A CB    1 
ATOM   4824 C  CG    . PRO A 1 597 ? 160.754 115.099 164.627 1.00 159.73 ? 597 PRO A CG    1 
ATOM   4825 C  CD    . PRO A 1 597 ? 160.147 114.942 163.269 1.00 159.73 ? 597 PRO A CD    1 
ATOM   4826 N  N     . ILE A 1 598 ? 164.009 112.659 164.410 1.00 176.88 ? 598 ILE A N     1 
ATOM   4827 C  CA    . ILE A 1 598 ? 164.591 111.387 164.826 1.00 176.88 ? 598 ILE A CA    1 
ATOM   4828 C  C     . ILE A 1 598 ? 163.767 110.724 165.925 1.00 176.88 ? 598 ILE A C     1 
ATOM   4829 O  O     . ILE A 1 598 ? 163.730 109.491 166.019 1.00 176.88 ? 598 ILE A O     1 
ATOM   4830 C  CB    . ILE A 1 598 ? 166.060 111.591 165.252 1.00 176.88 ? 598 ILE A CB    1 
ATOM   4831 C  CG1   . ILE A 1 598 ? 166.159 112.462 166.510 1.00 176.88 ? 598 ILE A CG1   1 
ATOM   4832 C  CG2   . ILE A 1 598 ? 166.861 112.205 164.114 1.00 176.88 ? 598 ILE A CG2   1 
ATOM   4833 C  CD1   . ILE A 1 598 ? 166.347 111.681 167.798 1.00 176.88 ? 598 ILE A CD1   1 
ATOM   4834 N  N     . ASN A 1 599 ? 163.100 111.513 166.770 1.00 194.54 ? 599 ASN A N     1 
ATOM   4835 C  CA    . ASN A 1 599 ? 162.352 110.942 167.886 1.00 194.54 ? 599 ASN A CA    1 
ATOM   4836 C  C     . ASN A 1 599 ? 161.126 110.159 167.435 1.00 194.54 ? 599 ASN A C     1 
ATOM   4837 O  O     . ASN A 1 599 ? 160.544 109.426 168.243 1.00 194.54 ? 599 ASN A O     1 
ATOM   4838 C  CB    . ASN A 1 599 ? 161.928 112.046 168.856 1.00 194.54 ? 599 ASN A CB    1 
ATOM   4839 C  CG    . ASN A 1 599 ? 162.928 112.253 169.974 1.00 194.54 ? 599 ASN A CG    1 
ATOM   4840 O  OD1   . ASN A 1 599 ? 163.911 111.518 170.086 1.00 194.54 ? 599 ASN A OD1   1 
ATOM   4841 N  ND2   . ASN A 1 599 ? 162.683 113.253 170.811 1.00 194.54 ? 599 ASN A ND2   1 
ATOM   4842 N  N     . SER A 1 600 ? 160.723 110.296 166.180 1.00 182.15 ? 600 SER A N     1 
ATOM   4843 C  CA    . SER A 1 600 ? 159.543 109.594 165.693 1.00 182.15 ? 600 SER A CA    1 
ATOM   4844 C  C     . SER A 1 600 ? 159.858 108.119 165.475 1.00 182.15 ? 600 SER A C     1 
ATOM   4845 O  O     . SER A 1 600 ? 160.854 107.793 164.819 1.00 182.15 ? 600 SER A O     1 
ATOM   4846 C  CB    . SER A 1 600 ? 159.058 110.213 164.388 1.00 182.15 ? 600 SER A CB    1 
ATOM   4847 O  OG    . SER A 1 600 ? 159.969 109.942 163.338 1.00 182.15 ? 600 SER A OG    1 
ATOM   4848 N  N     . PRO A 1 601 ? 159.049 107.202 166.010 1.00 159.62 ? 601 PRO A N     1 
ATOM   4849 C  CA    . PRO A 1 601 ? 159.245 105.781 165.681 1.00 159.62 ? 601 PRO A CA    1 
ATOM   4850 C  C     . PRO A 1 601 ? 159.149 105.503 164.193 1.00 159.62 ? 601 PRO A C     1 
ATOM   4851 O  O     . PRO A 1 601 ? 159.877 104.643 163.682 1.00 159.62 ? 601 PRO A O     1 
ATOM   4852 C  CB    . PRO A 1 601 ? 158.124 105.083 166.462 1.00 159.62 ? 601 PRO A CB    1 
ATOM   4853 C  CG    . PRO A 1 601 ? 157.779 106.033 167.563 1.00 159.62 ? 601 PRO A CG    1 
ATOM   4854 C  CD    . PRO A 1 601 ? 157.962 107.401 166.982 1.00 159.62 ? 601 PRO A CD    1 
ATOM   4855 N  N     . LEU A 1 602 ? 158.277 106.211 163.482 1.00 157.21 ? 602 LEU A N     1 
ATOM   4856 C  CA    . LEU A 1 602 ? 158.176 106.096 162.034 1.00 157.21 ? 602 LEU A CA    1 
ATOM   4857 C  C     . LEU A 1 602 ? 159.276 106.941 161.402 1.00 157.21 ? 602 LEU A C     1 
ATOM   4858 O  O     . LEU A 1 602 ? 159.476 108.097 161.792 1.00 157.21 ? 602 LEU A O     1 
ATOM   4859 C  CB    . LEU A 1 602 ? 156.792 106.534 161.555 1.00 157.21 ? 602 LEU A CB    1 
ATOM   4860 C  CG    . LEU A 1 602 ? 156.560 106.826 160.071 1.00 157.21 ? 602 LEU A CG    1 
ATOM   4861 C  CD1   . LEU A 1 602 ? 155.133 106.474 159.699 1.00 157.21 ? 602 LEU A CD1   1 
ATOM   4862 C  CD2   . LEU A 1 602 ? 156.826 108.288 159.749 1.00 157.21 ? 602 LEU A CD2   1 
ATOM   4863 N  N     . ARG A 1 603 ? 159.986 106.366 160.433 1.00 152.23 ? 603 ARG A N     1 
ATOM   4864 C  CA    . ARG A 1 603 ? 161.109 107.037 159.793 1.00 152.23 ? 603 ARG A CA    1 
ATOM   4865 C  C     . ARG A 1 603 ? 160.886 107.298 158.311 1.00 152.23 ? 603 ARG A C     1 
ATOM   4866 O  O     . ARG A 1 603 ? 161.420 108.271 157.772 1.00 152.23 ? 603 ARG A O     1 
ATOM   4867 C  CB    . ARG A 1 603 ? 162.386 106.211 159.976 1.00 152.23 ? 603 ARG A CB    1 
ATOM   4868 C  CG    . ARG A 1 603 ? 162.450 105.442 161.288 1.00 152.23 ? 603 ARG A CG    1 
ATOM   4869 C  CD    . ARG A 1 603 ? 162.636 106.371 162.477 1.00 152.23 ? 603 ARG A CD    1 
ATOM   4870 N  NE    . ARG A 1 603 ? 163.804 107.228 162.319 1.00 152.23 ? 603 ARG A NE    1 
ATOM   4871 C  CZ    . ARG A 1 603 ? 163.797 108.544 162.479 1.00 152.23 ? 603 ARG A CZ    1 
ATOM   4872 N  NH1   . ARG A 1 603 ? 162.694 109.193 162.817 1.00 152.23 ? 603 ARG A NH1   1 
ATOM   4873 N  NH2   . ARG A 1 603 ? 164.923 109.226 162.296 1.00 152.23 ? 603 ARG A NH2   1 
ATOM   4874 N  N     . GLU A 1 604 ? 160.116 106.452 157.642 1.00 158.87 ? 604 GLU A N     1 
ATOM   4875 C  CA    . GLU A 1 604 ? 159.918 106.591 156.203 1.00 158.87 ? 604 GLU A CA    1 
ATOM   4876 C  C     . GLU A 1 604 ? 159.142 107.869 155.904 1.00 158.87 ? 604 GLU A C     1 
ATOM   4877 O  O     . GLU A 1 604 ? 158.176 108.181 156.610 1.00 158.87 ? 604 GLU A O     1 
ATOM   4878 C  CB    . GLU A 1 604 ? 159.180 105.368 155.660 1.00 158.87 ? 604 GLU A CB    1 
ATOM   4879 C  CG    . GLU A 1 604 ? 159.353 105.112 154.169 1.00 158.87 ? 604 GLU A CG    1 
ATOM   4880 C  CD    . GLU A 1 604 ? 158.358 105.876 153.319 1.00 158.87 ? 604 GLU A CD    1 
ATOM   4881 O  OE1   . GLU A 1 604 ? 157.141 105.738 153.562 1.00 158.87 ? 604 GLU A OE1   1 
ATOM   4882 O  OE2   . GLU A 1 604 ? 158.788 106.601 152.398 1.00 158.87 ? 604 GLU A OE2   1 
ATOM   4883 N  N     . PRO A 1 605 ? 159.535 108.637 154.889 1.00 143.19 ? 605 PRO A N     1 
ATOM   4884 C  CA    . PRO A 1 605 ? 158.811 109.873 154.574 1.00 143.19 ? 605 PRO A CA    1 
ATOM   4885 C  C     . PRO A 1 605 ? 157.380 109.607 154.133 1.00 143.19 ? 605 PRO A C     1 
ATOM   4886 O  O     . PRO A 1 605 ? 157.075 108.593 153.502 1.00 143.19 ? 605 PRO A O     1 
ATOM   4887 C  CB    . PRO A 1 605 ? 159.635 110.488 153.436 1.00 143.19 ? 605 PRO A CB    1 
ATOM   4888 C  CG    . PRO A 1 605 ? 160.428 109.350 152.876 1.00 143.19 ? 605 PRO A CG    1 
ATOM   4889 C  CD    . PRO A 1 605 ? 160.728 108.468 154.045 1.00 143.19 ? 605 PRO A CD    1 
ATOM   4890 N  N     . ILE A 1 606 ? 156.501 110.548 154.468 1.00 134.69 ? 606 ILE A N     1 
ATOM   4891 C  CA    . ILE A 1 606 ? 155.081 110.466 154.150 1.00 134.69 ? 606 ILE A CA    1 
ATOM   4892 C  C     . ILE A 1 606 ? 154.793 111.423 153.005 1.00 134.69 ? 606 ILE A C     1 
ATOM   4893 O  O     . ILE A 1 606 ? 155.253 112.572 153.018 1.00 134.69 ? 606 ILE A O     1 
ATOM   4894 C  CB    . ILE A 1 606 ? 154.211 110.801 155.372 1.00 134.69 ? 606 ILE A CB    1 
ATOM   4895 C  CG1   . ILE A 1 606 ? 154.632 109.964 156.577 1.00 134.69 ? 606 ILE A CG1   1 
ATOM   4896 C  CG2   . ILE A 1 606 ? 152.746 110.573 155.057 1.00 134.69 ? 606 ILE A CG2   1 
ATOM   4897 C  CD1   . ILE A 1 606 ? 155.382 110.757 157.614 1.00 134.69 ? 606 ILE A CD1   1 
ATOM   4898 N  N     . THR A 1 607 ? 154.035 110.956 152.017 1.00 157.83 ? 607 THR A N     1 
ATOM   4899 C  CA    . THR A 1 607 ? 153.642 111.772 150.881 1.00 157.83 ? 607 THR A CA    1 
ATOM   4900 C  C     . THR A 1 607 ? 152.125 111.776 150.750 1.00 157.83 ? 607 THR A C     1 
ATOM   4901 O  O     . THR A 1 607 ? 151.441 110.870 151.235 1.00 157.83 ? 607 THR A O     1 
ATOM   4902 C  CB    . THR A 1 607 ? 154.280 111.270 149.576 1.00 157.83 ? 607 THR A CB    1 
ATOM   4903 O  OG1   . THR A 1 607 ? 154.059 112.229 148.533 1.00 157.83 ? 607 THR A OG1   1 
ATOM   4904 C  CG2   . THR A 1 607 ? 153.685 109.934 149.165 1.00 157.83 ? 607 THR A CG2   1 
ATOM   4905 N  N     . GLY A 1 608 ? 151.604 112.814 150.102 1.00 153.15 ? 608 GLY A N     1 
ATOM   4906 C  CA    . GLY A 1 608 ? 150.171 112.956 149.934 1.00 153.15 ? 608 GLY A CA    1 
ATOM   4907 C  C     . GLY A 1 608 ? 149.735 113.038 148.486 1.00 153.15 ? 608 GLY A C     1 
ATOM   4908 O  O     . GLY A 1 608 ? 150.552 112.897 147.572 1.00 153.15 ? 608 GLY A O     1 
ATOM   4909 N  N     . GLN A 1 609 ? 148.444 113.263 148.268 1.00 181.60 ? 609 GLN A N     1 
ATOM   4910 C  CA    . GLN A 1 609 ? 147.900 113.372 146.926 1.00 181.60 ? 609 GLN A CA    1 
ATOM   4911 C  C     . GLN A 1 609 ? 148.286 114.705 146.296 1.00 181.60 ? 609 GLN A C     1 
ATOM   4912 O  O     . GLN A 1 609 ? 148.619 115.662 146.998 1.00 181.60 ? 609 GLN A O     1 
ATOM   4913 C  CB    . GLN A 1 609 ? 146.381 113.232 146.964 1.00 181.60 ? 609 GLN A CB    1 
ATOM   4914 C  CG    . GLN A 1 609 ? 145.888 112.021 147.738 1.00 181.60 ? 609 GLN A CG    1 
ATOM   4915 C  CD    . GLN A 1 609 ? 144.566 112.274 148.435 1.00 181.60 ? 609 GLN A CD    1 
ATOM   4916 O  OE1   . GLN A 1 609 ? 143.681 112.934 147.891 1.00 181.60 ? 609 GLN A OE1   1 
ATOM   4917 N  NE2   . GLN A 1 609 ? 144.426 111.750 149.647 1.00 181.60 ? 609 GLN A NE2   1 
ATOM   4918 N  N     . PRO A 1 610 ? 148.277 114.788 144.965 1.00 200.30 ? 610 PRO A N     1 
ATOM   4919 C  CA    . PRO A 1 610 ? 148.541 116.069 144.301 1.00 200.30 ? 610 PRO A CA    1 
ATOM   4920 C  C     . PRO A 1 610 ? 147.277 116.885 144.074 1.00 200.30 ? 610 PRO A C     1 
ATOM   4921 O  O     . PRO A 1 610 ? 146.186 116.353 143.859 1.00 200.30 ? 610 PRO A O     1 
ATOM   4922 C  CB    . PRO A 1 610 ? 149.154 115.633 142.963 1.00 200.30 ? 610 PRO A CB    1 
ATOM   4923 C  CG    . PRO A 1 610 ? 148.494 114.331 142.677 1.00 200.30 ? 610 PRO A CG    1 
ATOM   4924 C  CD    . PRO A 1 610 ? 148.274 113.662 144.013 1.00 200.30 ? 610 PRO A CD    1 
ATOM   4925 N  N     . MET A 1 611 ? 147.439 118.202 144.130 1.00 196.55 ? 611 MET A N     1 
ATOM   4926 C  CA    . MET A 1 611 ? 146.372 119.149 143.837 1.00 196.55 ? 611 MET A CA    1 
ATOM   4927 C  C     . MET A 1 611 ? 147.014 120.484 143.485 1.00 196.55 ? 611 MET A C     1 
ATOM   4928 O  O     . MET A 1 611 ? 148.197 120.699 143.772 1.00 196.55 ? 611 MET A O     1 
ATOM   4929 C  CB    . MET A 1 611 ? 145.401 119.295 145.018 1.00 196.55 ? 611 MET A CB    1 
ATOM   4930 C  CG    . MET A 1 611 ? 145.910 120.181 146.120 1.00 196.55 ? 611 MET A CG    1 
ATOM   4931 S  SD    . MET A 1 611 ? 147.441 119.519 146.768 1.00 196.55 ? 611 MET A SD    1 
ATOM   4932 C  CE    . MET A 1 611 ? 146.798 118.110 147.668 1.00 196.55 ? 611 MET A CE    1 
ATOM   4933 N  N     . PRO A 1 612 ? 146.266 121.397 142.850 1.00 203.78 ? 612 PRO A N     1 
ATOM   4934 C  CA    . PRO A 1 612 ? 146.904 122.614 142.315 1.00 203.78 ? 612 PRO A CA    1 
ATOM   4935 C  C     . PRO A 1 612 ? 147.623 123.474 143.345 1.00 203.78 ? 612 PRO A C     1 
ATOM   4936 O  O     . PRO A 1 612 ? 148.648 124.079 143.006 1.00 203.78 ? 612 PRO A O     1 
ATOM   4937 C  CB    . PRO A 1 612 ? 145.728 123.369 141.677 1.00 203.78 ? 612 PRO A CB    1 
ATOM   4938 C  CG    . PRO A 1 612 ? 144.502 122.779 142.300 1.00 203.78 ? 612 PRO A CG    1 
ATOM   4939 C  CD    . PRO A 1 612 ? 144.843 121.339 142.474 1.00 203.78 ? 612 PRO A CD    1 
ATOM   4940 N  N     . SER A 1 613 ? 147.133 123.562 144.576 1.00 198.69 ? 613 SER A N     1 
ATOM   4941 C  CA    . SER A 1 613 ? 147.704 124.476 145.554 1.00 198.69 ? 613 SER A CA    1 
ATOM   4942 C  C     . SER A 1 613 ? 148.659 123.755 146.498 1.00 198.69 ? 613 SER A C     1 
ATOM   4943 O  O     . SER A 1 613 ? 148.462 122.587 146.843 1.00 198.69 ? 613 SER A O     1 
ATOM   4944 C  CB    . SER A 1 613 ? 146.605 125.170 146.359 1.00 198.69 ? 613 SER A CB    1 
ATOM   4945 O  OG    . SER A 1 613 ? 147.161 126.039 147.330 1.00 198.69 ? 613 SER A OG    1 
ATOM   4946 N  N     . LYS A 1 614 ? 149.705 124.475 146.912 1.00 172.62 ? 614 LYS A N     1 
ATOM   4947 C  CA    . LYS A 1 614 ? 150.738 123.900 147.768 1.00 172.62 ? 614 LYS A CA    1 
ATOM   4948 C  C     . LYS A 1 614 ? 150.279 123.783 149.217 1.00 172.62 ? 614 LYS A C     1 
ATOM   4949 O  O     . LYS A 1 614 ? 150.653 122.833 149.916 1.00 172.62 ? 614 LYS A O     1 
ATOM   4950 C  CB    . LYS A 1 614 ? 152.012 124.741 147.676 1.00 172.62 ? 614 LYS A CB    1 
ATOM   4951 C  CG    . LYS A 1 614 ? 153.139 124.277 148.578 1.00 172.62 ? 614 LYS A CG    1 
ATOM   4952 C  CD    . LYS A 1 614 ? 154.450 124.221 147.815 1.00 172.62 ? 614 LYS A CD    1 
ATOM   4953 C  CE    . LYS A 1 614 ? 154.898 125.606 147.383 1.00 172.62 ? 614 LYS A CE    1 
ATOM   4954 N  NZ    . LYS A 1 614 ? 156.245 125.579 146.751 1.00 172.62 ? 614 LYS A NZ    1 
ATOM   4955 N  N     . LYS A 1 615 ? 149.482 124.744 149.689 1.00 156.12 ? 615 LYS A N     1 
ATOM   4956 C  CA    . LYS A 1 615 ? 148.968 124.665 151.052 1.00 156.12 ? 615 LYS A CA    1 
ATOM   4957 C  C     . LYS A 1 615 ? 148.088 123.435 151.231 1.00 156.12 ? 615 LYS A C     1 
ATOM   4958 O  O     . LYS A 1 615 ? 148.168 122.746 152.255 1.00 156.12 ? 615 LYS A O     1 
ATOM   4959 C  CB    . LYS A 1 615 ? 148.198 125.938 151.395 1.00 156.12 ? 615 LYS A CB    1 
ATOM   4960 C  CG    . LYS A 1 615 ? 148.272 126.333 152.861 1.00 156.12 ? 615 LYS A CG    1 
ATOM   4961 C  CD    . LYS A 1 615 ? 147.852 127.782 153.080 1.00 156.12 ? 615 LYS A CD    1 
ATOM   4962 C  CE    . LYS A 1 615 ? 146.785 128.222 152.086 1.00 156.12 ? 615 LYS A CE    1 
ATOM   4963 N  NZ    . LYS A 1 615 ? 146.563 129.693 152.121 1.00 156.12 ? 615 LYS A NZ    1 
ATOM   4964 N  N     . LEU A 1 616 ? 147.249 123.138 150.237 1.00 168.82 ? 616 LEU A N     1 
ATOM   4965 C  CA    . LEU A 1 616 ? 146.469 121.909 150.289 1.00 168.82 ? 616 LEU A CA    1 
ATOM   4966 C  C     . LEU A 1 616 ? 147.358 120.675 150.202 1.00 168.82 ? 616 LEU A C     1 
ATOM   4967 O  O     . LEU A 1 616 ? 147.010 119.632 150.757 1.00 168.82 ? 616 LEU A O     1 
ATOM   4968 C  CB    . LEU A 1 616 ? 145.418 121.891 149.179 1.00 168.82 ? 616 LEU A CB    1 
ATOM   4969 C  CG    . LEU A 1 616 ? 144.841 123.220 148.695 1.00 168.82 ? 616 LEU A CG    1 
ATOM   4970 C  CD1   . LEU A 1 616 ? 143.849 122.981 147.570 1.00 168.82 ? 616 LEU A CD1   1 
ATOM   4971 C  CD2   . LEU A 1 616 ? 144.171 123.970 149.835 1.00 168.82 ? 616 LEU A CD2   1 
ATOM   4972 N  N     . ALA A 1 617 ? 148.500 120.767 149.515 1.00 181.37 ? 617 ALA A N     1 
ATOM   4973 C  CA    . ALA A 1 617 ? 149.445 119.652 149.523 1.00 181.37 ? 617 ALA A CA    1 
ATOM   4974 C  C     . ALA A 1 617 ? 149.987 119.407 150.923 1.00 181.37 ? 617 ALA A C     1 
ATOM   4975 O  O     . ALA A 1 617 ? 150.069 118.257 151.378 1.00 181.37 ? 617 ALA A O     1 
ATOM   4976 C  CB    . ALA A 1 617 ? 150.585 119.920 148.540 1.00 181.37 ? 617 ALA A CB    1 
ATOM   4977 N  N     . LYS A 1 618 ? 150.358 120.482 151.622 1.00 170.57 ? 618 LYS A N     1 
ATOM   4978 C  CA    . LYS A 1 618 ? 150.815 120.346 153.000 1.00 170.57 ? 618 LYS A CA    1 
ATOM   4979 C  C     . LYS A 1 618 ? 149.718 119.761 153.880 1.00 170.57 ? 618 LYS A C     1 
ATOM   4980 O  O     . LYS A 1 618 ? 149.979 118.884 154.711 1.00 170.57 ? 618 LYS A O     1 
ATOM   4981 C  CB    . LYS A 1 618 ? 151.272 121.704 153.532 1.00 170.57 ? 618 LYS A CB    1 
ATOM   4982 C  CG    . LYS A 1 618 ? 151.621 121.718 155.009 1.00 170.57 ? 618 LYS A CG    1 
ATOM   4983 C  CD    . LYS A 1 618 ? 152.126 123.089 155.430 1.00 170.57 ? 618 LYS A CD    1 
ATOM   4984 C  CE    . LYS A 1 618 ? 152.758 123.049 156.811 1.00 170.57 ? 618 LYS A CE    1 
ATOM   4985 N  NZ    . LYS A 1 618 ? 153.498 124.302 157.122 1.00 170.57 ? 618 LYS A NZ    1 
ATOM   4986 N  N     . ARG A 1 619 ? 148.480 120.223 153.695 1.00 153.84 ? 619 ARG A N     1 
ATOM   4987 C  CA    . ARG A 1 619 ? 147.368 119.702 154.487 1.00 153.84 ? 619 ARG A CA    1 
ATOM   4988 C  C     . ARG A 1 619 ? 147.112 118.226 154.196 1.00 153.84 ? 619 ARG A C     1 
ATOM   4989 O  O     . ARG A 1 619 ? 146.817 117.449 155.112 1.00 153.84 ? 619 ARG A O     1 
ATOM   4990 C  CB    . ARG A 1 619 ? 146.111 120.530 154.228 1.00 153.84 ? 619 ARG A CB    1 
ATOM   4991 C  CG    . ARG A 1 619 ? 146.233 121.979 154.665 1.00 153.84 ? 619 ARG A CG    1 
ATOM   4992 C  CD    . ARG A 1 619 ? 145.260 122.868 153.910 1.00 153.84 ? 619 ARG A CD    1 
ATOM   4993 N  NE    . ARG A 1 619 ? 144.862 124.025 154.702 1.00 153.84 ? 619 ARG A NE    1 
ATOM   4994 C  CZ    . ARG A 1 619 ? 144.272 125.103 154.205 1.00 153.84 ? 619 ARG A CZ    1 
ATOM   4995 N  NH1   . ARG A 1 619 ? 143.997 125.210 152.916 1.00 153.84 ? 619 ARG A NH1   1 
ATOM   4996 N  NH2   . ARG A 1 619 ? 143.951 126.102 155.024 1.00 153.84 ? 619 ARG A NH2   1 
ATOM   4997 N  N     . SER A 1 620 ? 147.201 117.822 152.927 1.00 156.80 ? 620 SER A N     1 
ATOM   4998 C  CA    . SER A 1 620 ? 146.990 116.422 152.571 1.00 156.80 ? 620 SER A CA    1 
ATOM   4999 C  C     . SER A 1 620 ? 148.069 115.531 153.169 1.00 156.80 ? 620 SER A C     1 
ATOM   5000 O  O     . SER A 1 620 ? 147.769 114.455 153.706 1.00 156.80 ? 620 SER A O     1 
ATOM   5001 C  CB    . SER A 1 620 ? 146.953 116.269 151.051 1.00 156.80 ? 620 SER A CB    1 
ATOM   5002 O  OG    . SER A 1 620 ? 146.859 114.906 150.676 1.00 156.80 ? 620 SER A OG    1 
ATOM   5003 N  N     . ALA A 1 621 ? 149.331 115.957 153.081 1.00 143.99 ? 621 ALA A N     1 
ATOM   5004 C  CA    . ALA A 1 621 ? 150.399 115.200 153.723 1.00 143.99 ? 621 ALA A CA    1 
ATOM   5005 C  C     . ALA A 1 621 ? 150.183 115.133 155.227 1.00 143.99 ? 621 ALA A C     1 
ATOM   5006 O  O     . ALA A 1 621 ? 150.419 114.091 155.851 1.00 143.99 ? 621 ALA A O     1 
ATOM   5007 C  CB    . ALA A 1 621 ? 151.755 115.825 153.400 1.00 143.99 ? 621 ALA A CB    1 
ATOM   5008 N  N     . ALA A 1 622 ? 149.718 116.233 155.822 1.00 133.02 ? 622 ALA A N     1 
ATOM   5009 C  CA    . ALA A 1 622 ? 149.436 116.256 157.251 1.00 133.02 ? 622 ALA A CA    1 
ATOM   5010 C  C     . ALA A 1 622 ? 148.365 115.238 157.619 1.00 133.02 ? 622 ALA A C     1 
ATOM   5011 O  O     . ALA A 1 622 ? 148.506 114.495 158.596 1.00 133.02 ? 622 ALA A O     1 
ATOM   5012 C  CB    . ALA A 1 622 ? 149.002 117.663 157.659 1.00 133.02 ? 622 ALA A CB    1 
ATOM   5013 N  N     . LEU A 1 623 ? 147.281 115.198 156.844 1.00 150.15 ? 623 LEU A N     1 
ATOM   5014 C  CA    . LEU A 1 623 ? 146.193 114.269 157.133 1.00 150.15 ? 623 LEU A CA    1 
ATOM   5015 C  C     . LEU A 1 623 ? 146.644 112.824 156.970 1.00 150.15 ? 623 LEU A C     1 
ATOM   5016 O  O     . LEU A 1 623 ? 146.303 111.960 157.790 1.00 150.15 ? 623 LEU A O     1 
ATOM   5017 C  CB    . LEU A 1 623 ? 144.998 114.564 156.229 1.00 150.15 ? 623 LEU A CB    1 
ATOM   5018 C  CG    . LEU A 1 623 ? 143.610 114.278 156.807 1.00 150.15 ? 623 LEU A CG    1 
ATOM   5019 C  CD1   . LEU A 1 623 ? 143.603 114.452 158.317 1.00 150.15 ? 623 LEU A CD1   1 
ATOM   5020 C  CD2   . LEU A 1 623 ? 142.569 115.173 156.159 1.00 150.15 ? 623 LEU A CD2   1 
ATOM   5021 N  N     . GLU A 1 624 ? 147.407 112.538 155.912 1.00 132.65 ? 624 GLU A N     1 
ATOM   5022 C  CA    . GLU A 1 624 ? 147.904 111.182 155.716 1.00 132.65 ? 624 GLU A CA    1 
ATOM   5023 C  C     . GLU A 1 624 ? 148.824 110.766 156.857 1.00 132.65 ? 624 GLU A C     1 
ATOM   5024 O  O     . GLU A 1 624 ? 148.738 109.636 157.356 1.00 132.65 ? 624 GLU A O     1 
ATOM   5025 C  CB    . GLU A 1 624 ? 148.629 111.077 154.375 1.00 132.65 ? 624 GLU A CB    1 
ATOM   5026 C  CG    . GLU A 1 624 ? 149.277 109.728 154.127 1.00 132.65 ? 624 GLU A CG    1 
ATOM   5027 C  CD    . GLU A 1 624 ? 148.266 108.603 154.050 1.00 132.65 ? 624 GLU A CD    1 
ATOM   5028 O  OE1   . GLU A 1 624 ? 147.147 108.843 153.551 1.00 132.65 ? 624 GLU A OE1   1 
ATOM   5029 O  OE2   . GLU A 1 624 ? 148.590 107.480 154.489 1.00 132.65 ? 624 GLU A OE2   1 
ATOM   5030 N  N     . ALA A 1 625 ? 149.707 111.670 157.288 1.00 128.16 ? 625 ALA A N     1 
ATOM   5031 C  CA    . ALA A 1 625 ? 150.593 111.368 158.404 1.00 128.16 ? 625 ALA A CA    1 
ATOM   5032 C  C     . ALA A 1 625 ? 149.807 111.135 159.685 1.00 128.16 ? 625 ALA A C     1 
ATOM   5033 O  O     . ALA A 1 625 ? 150.137 110.240 160.467 1.00 128.16 ? 625 ALA A O     1 
ATOM   5034 C  CB    . ALA A 1 625 ? 151.605 112.496 158.592 1.00 128.16 ? 625 ALA A CB    1 
ATOM   5035 N  N     . CYS A 1 626 ? 148.767 111.938 159.921 1.00 157.00 ? 626 CYS A N     1 
ATOM   5036 C  CA    . CYS A 1 626 ? 147.943 111.754 161.111 1.00 157.00 ? 626 CYS A CA    1 
ATOM   5037 C  C     . CYS A 1 626 ? 147.256 110.396 161.095 1.00 157.00 ? 626 CYS A C     1 
ATOM   5038 O  O     . CYS A 1 626 ? 147.225 109.689 162.111 1.00 157.00 ? 626 CYS A O     1 
ATOM   5039 C  CB    . CYS A 1 626 ? 146.912 112.877 161.215 1.00 157.00 ? 626 CYS A CB    1 
ATOM   5040 S  SG    . CYS A 1 626 ? 147.597 114.487 161.659 1.00 157.00 ? 626 CYS A SG    1 
ATOM   5041 N  N     . LYS A 1 627 ? 146.697 110.013 159.945 1.00 147.90 ? 627 LYS A N     1 
ATOM   5042 C  CA    . LYS A 1 627 ? 146.035 108.716 159.846 1.00 147.90 ? 627 LYS A CA    1 
ATOM   5043 C  C     . LYS A 1 627 ? 147.022 107.579 160.072 1.00 147.90 ? 627 LYS A C     1 
ATOM   5044 O  O     . LYS A 1 627 ? 146.726 106.623 160.802 1.00 147.90 ? 627 LYS A O     1 
ATOM   5045 C  CB    . LYS A 1 627 ? 145.348 108.577 158.487 1.00 147.90 ? 627 LYS A CB    1 
ATOM   5046 C  CG    . LYS A 1 627 ? 145.469 107.198 157.859 1.00 147.90 ? 627 LYS A CG    1 
ATOM   5047 C  CD    . LYS A 1 627 ? 144.496 107.027 156.707 1.00 147.90 ? 627 LYS A CD    1 
ATOM   5048 C  CE    . LYS A 1 627 ? 144.718 108.079 155.636 1.00 147.90 ? 627 LYS A CE    1 
ATOM   5049 N  NZ    . LYS A 1 627 ? 143.641 108.059 154.608 1.00 147.90 ? 627 LYS A NZ    1 
ATOM   5050 N  N     . LYS A 1 628 ? 148.213 107.675 159.474 1.00 150.31 ? 628 LYS A N     1 
ATOM   5051 C  CA    . LYS A 1 628 ? 149.213 106.628 159.657 1.00 150.31 ? 628 LYS A CA    1 
ATOM   5052 C  C     . LYS A 1 628 ? 149.661 106.539 161.110 1.00 150.31 ? 628 LYS A C     1 
ATOM   5053 O  O     . LYS A 1 628 ? 149.814 105.440 161.656 1.00 150.31 ? 628 LYS A O     1 
ATOM   5054 C  CB    . LYS A 1 628 ? 150.408 106.884 158.740 1.00 150.31 ? 628 LYS A CB    1 
ATOM   5055 C  CG    . LYS A 1 628 ? 151.396 105.736 158.680 1.00 150.31 ? 628 LYS A CG    1 
ATOM   5056 C  CD    . LYS A 1 628 ? 150.793 104.533 157.977 1.00 150.31 ? 628 LYS A CD    1 
ATOM   5057 C  CE    . LYS A 1 628 ? 151.812 103.417 157.827 1.00 150.31 ? 628 LYS A CE    1 
ATOM   5058 N  NZ    . LYS A 1 628 ? 152.940 103.819 156.943 1.00 150.31 ? 628 LYS A NZ    1 
ATOM   5059 N  N     . LEU A 1 629 ? 149.870 107.688 161.756 1.00 150.23 ? 629 LEU A N     1 
ATOM   5060 C  CA    . LEU A 1 629 ? 150.321 107.696 163.141 1.00 150.23 ? 629 LEU A CA    1 
ATOM   5061 C  C     . LEU A 1 629 ? 149.258 107.117 164.066 1.00 150.23 ? 629 LEU A C     1 
ATOM   5062 O  O     . LEU A 1 629 ? 149.580 106.369 164.997 1.00 150.23 ? 629 LEU A O     1 
ATOM   5063 C  CB    . LEU A 1 629 ? 150.692 109.121 163.555 1.00 150.23 ? 629 LEU A CB    1 
ATOM   5064 C  CG    . LEU A 1 629 ? 151.882 109.335 164.495 1.00 150.23 ? 629 LEU A CG    1 
ATOM   5065 C  CD1   . LEU A 1 629 ? 152.131 110.822 164.700 1.00 150.23 ? 629 LEU A CD1   1 
ATOM   5066 C  CD2   . LEU A 1 629 ? 151.686 108.642 165.833 1.00 150.23 ? 629 LEU A CD2   1 
ATOM   5067 N  N     . HIS A 1 630 ? 147.988 107.449 163.829 1.00 163.06 ? 630 HIS A N     1 
ATOM   5068 C  CA    . HIS A 1 630 ? 146.917 106.840 164.611 1.00 163.06 ? 630 HIS A CA    1 
ATOM   5069 C  C     . HIS A 1 630 ? 146.863 105.336 164.377 1.00 163.06 ? 630 HIS A C     1 
ATOM   5070 O  O     . HIS A 1 630 ? 146.612 104.563 165.308 1.00 163.06 ? 630 HIS A O     1 
ATOM   5071 C  CB    . HIS A 1 630 ? 145.574 107.487 164.272 1.00 163.06 ? 630 HIS A CB    1 
ATOM   5072 C  CG    . HIS A 1 630 ? 144.403 106.826 164.933 1.00 163.06 ? 630 HIS A CG    1 
ATOM   5073 N  ND1   . HIS A 1 630 ? 143.237 106.532 164.261 1.00 163.06 ? 630 HIS A ND1   1 
ATOM   5074 C  CD2   . HIS A 1 630 ? 144.220 106.406 166.207 1.00 163.06 ? 630 HIS A CD2   1 
ATOM   5075 C  CE1   . HIS A 1 630 ? 142.386 105.956 165.092 1.00 163.06 ? 630 HIS A CE1   1 
ATOM   5076 N  NE2   . HIS A 1 630 ? 142.958 105.869 166.279 1.00 163.06 ? 630 HIS A NE2   1 
ATOM   5077 N  N     . GLU A 1 631 ? 147.095 104.903 163.134 1.00 170.40 ? 631 GLU A N     1 
ATOM   5078 C  CA    . GLU A 1 631 ? 147.144 103.474 162.846 1.00 170.40 ? 631 GLU A CA    1 
ATOM   5079 C  C     . GLU A 1 631 ? 148.272 102.786 163.605 1.00 170.40 ? 631 GLU A C     1 
ATOM   5080 O  O     . GLU A 1 631 ? 148.117 101.638 164.035 1.00 170.40 ? 631 GLU A O     1 
ATOM   5081 C  CB    . GLU A 1 631 ? 147.298 103.246 161.343 1.00 170.40 ? 631 GLU A CB    1 
ATOM   5082 C  CG    . GLU A 1 631 ? 145.994 103.324 160.571 1.00 170.40 ? 631 GLU A CG    1 
ATOM   5083 C  CD    . GLU A 1 631 ? 146.204 103.629 159.103 1.00 170.40 ? 631 GLU A CD    1 
ATOM   5084 O  OE1   . GLU A 1 631 ? 147.341 103.456 158.617 1.00 170.40 ? 631 GLU A OE1   1 
ATOM   5085 O  OE2   . GLU A 1 631 ? 145.233 104.038 158.434 1.00 170.40 ? 631 GLU A OE2   1 
ATOM   5086 N  N     . MET A 1 632 ? 149.412 103.463 163.771 1.00 160.56 ? 632 MET A N     1 
ATOM   5087 C  CA    . MET A 1 632 ? 150.513 102.869 164.525 1.00 160.56 ? 632 MET A CA    1 
ATOM   5088 C  C     . MET A 1 632 ? 150.119 102.609 165.974 1.00 160.56 ? 632 MET A C     1 
ATOM   5089 O  O     . MET A 1 632 ? 150.441 101.552 166.528 1.00 160.56 ? 632 MET A O     1 
ATOM   5090 C  CB    . MET A 1 632 ? 151.750 103.762 164.453 1.00 160.56 ? 632 MET A CB    1 
ATOM   5091 C  CG    . MET A 1 632 ? 152.249 104.019 163.043 1.00 160.56 ? 632 MET A CG    1 
ATOM   5092 S  SD    . MET A 1 632 ? 153.335 102.709 162.446 1.00 160.56 ? 632 MET A SD    1 
ATOM   5093 C  CE    . MET A 1 632 ? 154.939 103.481 162.639 1.00 160.56 ? 632 MET A CE    1 
ATOM   5094 N  N     . GLY A 1 633 ? 149.425 103.552 166.606 1.00 177.31 ? 633 GLY A N     1 
ATOM   5095 C  CA    . GLY A 1 633 ? 148.891 103.339 167.942 1.00 177.31 ? 633 GLY A CA    1 
ATOM   5096 C  C     . GLY A 1 633 ? 149.319 104.342 168.996 1.00 177.31 ? 633 GLY A C     1 
ATOM   5097 O  O     . GLY A 1 633 ? 148.984 104.145 170.174 1.00 177.31 ? 633 GLY A O     1 
ATOM   5098 N  N     . GLU A 1 634 ? 150.048 105.408 168.659 1.00 189.99 ? 634 GLU A N     1 
ATOM   5099 C  CA    . GLU A 1 634 ? 150.414 106.393 169.672 1.00 189.99 ? 634 GLU A CA    1 
ATOM   5100 C  C     . GLU A 1 634 ? 149.199 107.195 170.122 1.00 189.99 ? 634 GLU A C     1 
ATOM   5101 O  O     . GLU A 1 634 ? 148.994 107.410 171.322 1.00 189.99 ? 634 GLU A O     1 
ATOM   5102 C  CB    . GLU A 1 634 ? 151.506 107.320 169.134 1.00 189.99 ? 634 GLU A CB    1 
ATOM   5103 C  CG    . GLU A 1 634 ? 152.038 108.330 170.147 1.00 189.99 ? 634 GLU A CG    1 
ATOM   5104 C  CD    . GLU A 1 634 ? 151.153 109.556 170.280 1.00 189.99 ? 634 GLU A CD    1 
ATOM   5105 O  OE1   . GLU A 1 634 ? 150.483 109.916 169.291 1.00 189.99 ? 634 GLU A OE1   1 
ATOM   5106 O  OE2   . GLU A 1 634 ? 151.121 110.153 171.376 1.00 189.99 ? 634 GLU A OE2   1 
ATOM   5107 N  N     . LEU A 1 635 ? 148.393 107.659 169.172 1.00 191.45 ? 635 LEU A N     1 
ATOM   5108 C  CA    . LEU A 1 635 ? 147.223 108.460 169.499 1.00 191.45 ? 635 LEU A CA    1 
ATOM   5109 C  C     . LEU A 1 635 ? 146.203 107.628 170.268 1.00 191.45 ? 635 LEU A C     1 
ATOM   5110 O  O     . LEU A 1 635 ? 146.037 106.431 170.017 1.00 191.45 ? 635 LEU A O     1 
ATOM   5111 C  CB    . LEU A 1 635 ? 146.597 109.021 168.224 1.00 191.45 ? 635 LEU A CB    1 
ATOM   5112 C  CG    . LEU A 1 635 ? 147.416 110.092 167.499 1.00 191.45 ? 635 LEU A CG    1 
ATOM   5113 C  CD1   . LEU A 1 635 ? 146.738 110.512 166.206 1.00 191.45 ? 635 LEU A CD1   1 
ATOM   5114 C  CD2   . LEU A 1 635 ? 147.647 111.291 168.400 1.00 191.45 ? 635 LEU A CD2   1 
ATOM   5115 N  N     . ASP A 1 636 ? 145.518 108.268 171.210 1.00 199.05 ? 636 ASP A N     1 
ATOM   5116 C  CA    . ASP A 1 636 ? 144.574 107.576 172.076 1.00 199.05 ? 636 ASP A CA    1 
ATOM   5117 C  C     . ASP A 1 636 ? 143.208 107.478 171.396 1.00 199.05 ? 636 ASP A C     1 
ATOM   5118 O  O     . ASP A 1 636 ? 143.062 107.711 170.192 1.00 199.05 ? 636 ASP A O     1 
ATOM   5119 C  CB    . ASP A 1 636 ? 144.484 108.269 173.433 1.00 199.05 ? 636 ASP A CB    1 
ATOM   5120 C  CG    . ASP A 1 636 ? 144.157 109.743 173.319 1.00 199.05 ? 636 ASP A CG    1 
ATOM   5121 O  OD1   . ASP A 1 636 ? 143.922 110.227 172.192 1.00 199.05 ? 636 ASP A OD1   1 
ATOM   5122 O  OD2   . ASP A 1 636 ? 144.127 110.418 174.369 1.00 199.05 ? 636 ASP A OD2   1 
ATOM   5123 N  N     . ASP A 1 637 ? 142.191 107.115 172.181 1.00 190.80 ? 637 ASP A N     1 
ATOM   5124 C  CA    . ASP A 1 637 ? 140.855 106.897 171.633 1.00 190.80 ? 637 ASP A CA    1 
ATOM   5125 C  C     . ASP A 1 637 ? 140.287 108.165 171.006 1.00 190.80 ? 637 ASP A C     1 
ATOM   5126 O  O     . ASP A 1 637 ? 139.691 108.115 169.924 1.00 190.80 ? 637 ASP A O     1 
ATOM   5127 C  CB    . ASP A 1 637 ? 139.924 106.384 172.732 1.00 190.80 ? 637 ASP A CB    1 
ATOM   5128 C  CG    . ASP A 1 637 ? 138.585 105.920 172.196 1.00 190.80 ? 637 ASP A CG    1 
ATOM   5129 O  OD1   . ASP A 1 637 ? 138.449 105.773 170.963 1.00 190.80 ? 637 ASP A OD1   1 
ATOM   5130 O  OD2   . ASP A 1 637 ? 137.663 105.705 173.010 1.00 190.80 ? 637 ASP A OD2   1 
ATOM   5131 N  N     . HIS A 1 638 ? 140.461 109.308 171.663 1.00 190.39 ? 638 HIS A N     1 
ATOM   5132 C  CA    . HIS A 1 638 ? 139.851 110.553 171.214 1.00 190.39 ? 638 HIS A CA    1 
ATOM   5133 C  C     . HIS A 1 638 ? 140.757 111.368 170.300 1.00 190.39 ? 638 HIS A C     1 
ATOM   5134 O  O     . HIS A 1 638 ? 140.553 112.578 170.166 1.00 190.39 ? 638 HIS A O     1 
ATOM   5135 C  CB    . HIS A 1 638 ? 139.425 111.391 172.421 1.00 190.39 ? 638 HIS A CB    1 
ATOM   5136 C  CG    . HIS A 1 638 ? 138.157 110.916 173.058 1.00 190.39 ? 638 HIS A CG    1 
ATOM   5137 N  ND1   . HIS A 1 638 ? 137.120 110.372 172.332 1.00 190.39 ? 638 HIS A ND1   1 
ATOM   5138 C  CD2   . HIS A 1 638 ? 137.763 110.892 174.353 1.00 190.39 ? 638 HIS A CD2   1 
ATOM   5139 C  CE1   . HIS A 1 638 ? 136.139 110.038 173.151 1.00 190.39 ? 638 HIS A CE1   1 
ATOM   5140 N  NE2   . HIS A 1 638 ? 136.504 110.344 174.383 1.00 190.39 ? 638 HIS A NE2   1 
ATOM   5141 N  N     . LEU A 1 639 ? 141.750 110.735 169.678 1.00 190.37 ? 639 LEU A N     1 
ATOM   5142 C  CA    . LEU A 1 639 ? 142.593 111.315 168.634 1.00 190.37 ? 639 LEU A CA    1 
ATOM   5143 C  C     . LEU A 1 639 ? 143.363 112.547 169.085 1.00 190.37 ? 639 LEU A C     1 
ATOM   5144 O  O     . LEU A 1 639 ? 143.681 113.404 168.253 1.00 190.37 ? 639 LEU A O     1 
ATOM   5145 C  CB    . LEU A 1 639 ? 141.780 111.661 167.382 1.00 190.37 ? 639 LEU A CB    1 
ATOM   5146 C  CG    . LEU A 1 639 ? 141.592 110.525 166.375 1.00 190.37 ? 639 LEU A CG    1 
ATOM   5147 C  CD1   . LEU A 1 639 ? 140.423 109.639 166.773 1.00 190.37 ? 639 LEU A CD1   1 
ATOM   5148 C  CD2   . LEU A 1 639 ? 141.397 111.074 164.972 1.00 190.37 ? 639 LEU A CD2   1 
ATOM   5149 N  N     . LEU A 1 640 ? 143.669 112.673 170.371 1.00 225.78 ? 640 LEU A N     1 
ATOM   5150 C  CA    . LEU A 1 640 ? 144.531 113.777 170.767 1.00 225.78 ? 640 LEU A CA    1 
ATOM   5151 C  C     . LEU A 1 640 ? 145.939 113.263 171.064 1.00 225.78 ? 640 LEU A C     1 
ATOM   5152 O  O     . LEU A 1 640 ? 146.102 112.115 171.486 1.00 225.78 ? 640 LEU A O     1 
ATOM   5153 C  CB    . LEU A 1 640 ? 143.943 114.515 171.979 1.00 225.78 ? 640 LEU A CB    1 
ATOM   5154 C  CG    . LEU A 1 640 ? 143.675 113.900 173.363 1.00 225.78 ? 640 LEU A CG    1 
ATOM   5155 C  CD1   . LEU A 1 640 ? 144.926 113.455 174.113 1.00 225.78 ? 640 LEU A CD1   1 
ATOM   5156 C  CD2   . LEU A 1 640 ? 142.865 114.870 174.212 1.00 225.78 ? 640 LEU A CD2   1 
ATOM   5157 N  N     . PRO A 1 641 ? 146.970 114.073 170.823 1.00 235.18 ? 641 PRO A N     1 
ATOM   5158 C  CA    . PRO A 1 641 ? 148.338 113.621 171.102 1.00 235.18 ? 641 PRO A CA    1 
ATOM   5159 C  C     . PRO A 1 641 ? 148.514 113.270 172.570 1.00 235.18 ? 641 PRO A C     1 
ATOM   5160 O  O     . PRO A 1 641 ? 148.007 113.957 173.460 1.00 235.18 ? 641 PRO A O     1 
ATOM   5161 C  CB    . PRO A 1 641 ? 149.197 114.826 170.703 1.00 235.18 ? 641 PRO A CB    1 
ATOM   5162 C  CG    . PRO A 1 641 ? 148.363 115.569 169.716 1.00 235.18 ? 641 PRO A CG    1 
ATOM   5163 C  CD    . PRO A 1 641 ? 146.948 115.399 170.184 1.00 235.18 ? 641 PRO A CD    1 
ATOM   5164 N  N     . VAL A 1 642 ? 149.252 112.193 172.818 1.00 286.89 ? 642 VAL A N     1 
ATOM   5165 C  CA    . VAL A 1 642 ? 149.438 111.651 174.158 1.00 286.89 ? 642 VAL A CA    1 
ATOM   5166 C  C     . VAL A 1 642 ? 150.883 111.877 174.571 1.00 286.89 ? 642 VAL A C     1 
ATOM   5167 O  O     . VAL A 1 642 ? 151.809 111.552 173.819 1.00 286.89 ? 642 VAL A O     1 
ATOM   5168 C  CB    . VAL A 1 642 ? 149.080 110.157 174.216 1.00 286.89 ? 642 VAL A CB    1 
ATOM   5169 C  CG1   . VAL A 1 642 ? 149.257 109.623 175.630 1.00 286.89 ? 642 VAL A CG1   1 
ATOM   5170 C  CG2   . VAL A 1 642 ? 147.662 109.937 173.726 1.00 286.89 ? 642 VAL A CG2   1 
ATOM   5171 N  N     . LYS A 1 643 ? 151.075 112.435 175.763 1.00 418.15 ? 643 LYS A N     1 
ATOM   5172 C  CA    . LYS A 1 643 ? 152.416 112.634 176.303 1.00 418.15 ? 643 LYS A CA    1 
ATOM   5173 C  C     . LYS A 1 643 ? 152.976 111.275 176.696 1.00 418.15 ? 643 LYS A C     1 
ATOM   5174 O  O     . LYS A 1 643 ? 152.765 110.797 177.813 1.00 418.15 ? 643 LYS A O     1 
ATOM   5175 C  CB    . LYS A 1 643 ? 152.382 113.587 177.492 1.00 418.15 ? 643 LYS A CB    1 
ATOM   5176 C  CG    . LYS A 1 643 ? 152.324 115.056 177.107 1.00 418.15 ? 643 LYS A CG    1 
ATOM   5177 C  CD    . LYS A 1 643 ? 153.650 115.748 177.382 1.00 418.15 ? 643 LYS A CD    1 
ATOM   5178 C  CE    . LYS A 1 643 ? 153.509 117.260 177.322 1.00 418.15 ? 643 LYS A CE    1 
ATOM   5179 N  NZ    . LYS A 1 643 ? 154.825 117.946 177.433 1.00 418.15 ? 643 LYS A NZ    1 
ATOM   5180 N  N     . ILE A 1 644 ? 153.698 110.646 175.770 1.00 562.50 ? 644 ILE A N     1 
ATOM   5181 C  CA    . ILE A 1 644 ? 154.259 109.315 175.985 1.00 562.50 ? 644 ILE A CA    1 
ATOM   5182 C  C     . ILE A 1 644 ? 155.483 109.481 176.882 1.00 562.50 ? 644 ILE A C     1 
ATOM   5183 O  O     . ILE A 1 644 ? 156.567 109.831 176.415 1.00 562.50 ? 644 ILE A O     1 
ATOM   5184 C  CB    . ILE A 1 644 ? 154.615 108.625 174.667 1.00 562.50 ? 644 ILE A CB    1 
ATOM   5185 C  CG1   . ILE A 1 644 ? 153.406 108.605 173.727 1.00 562.50 ? 644 ILE A CG1   1 
ATOM   5186 C  CG2   . ILE A 1 644 ? 155.111 107.209 174.924 1.00 562.50 ? 644 ILE A CG2   1 
ATOM   5187 C  CD1   . ILE A 1 644 ? 152.213 107.862 174.280 1.00 562.50 ? 644 ILE A CD1   1 
ATOM   5188 N  N     . SER A 1 645 ? 155.309 109.235 178.177 1.00 717.27 ? 645 SER A N     1 
ATOM   5189 C  CA    . SER A 1 645 ? 156.418 109.327 179.111 1.00 717.27 ? 645 SER A CA    1 
ATOM   5190 C  C     . SER A 1 645 ? 157.408 108.190 178.870 1.00 717.27 ? 645 SER A C     1 
ATOM   5191 O  O     . SER A 1 645 ? 157.161 107.262 178.094 1.00 717.27 ? 645 SER A O     1 
ATOM   5192 C  CB    . SER A 1 645 ? 155.906 109.297 180.551 1.00 717.27 ? 645 SER A CB    1 
ATOM   5193 O  OG    . SER A 1 645 ? 154.797 110.162 180.716 1.00 717.27 ? 645 SER A OG    1 
ATOM   5194 N  N     . ARG A 1 646 ? 158.557 108.277 179.548 1.00 798.29 ? 646 ARG A N     1 
ATOM   5195 C  CA    . ARG A 1 646 ? 159.557 107.220 179.437 1.00 798.29 ? 646 ARG A CA    1 
ATOM   5196 C  C     . ARG A 1 646 ? 159.001 105.888 179.924 1.00 798.29 ? 646 ARG A C     1 
ATOM   5197 O  O     . ARG A 1 646 ? 159.228 104.845 179.297 1.00 798.29 ? 646 ARG A O     1 
ATOM   5198 C  CB    . ARG A 1 646 ? 160.815 107.606 180.218 1.00 798.29 ? 646 ARG A CB    1 
ATOM   5199 C  CG    . ARG A 1 646 ? 160.544 108.148 181.612 1.00 798.29 ? 646 ARG A CG    1 
ATOM   5200 C  CD    . ARG A 1 646 ? 161.784 108.802 182.199 1.00 798.29 ? 646 ARG A CD    1 
ATOM   5201 N  NE    . ARG A 1 646 ? 161.618 109.114 183.613 1.00 798.29 ? 646 ARG A NE    1 
ATOM   5202 C  CZ    . ARG A 1 646 ? 161.008 110.195 184.076 1.00 798.29 ? 646 ARG A CZ    1 
ATOM   5203 N  NH1   . ARG A 1 646 ? 160.490 111.099 183.259 1.00 798.29 ? 646 ARG A NH1   1 
ATOM   5204 N  NH2   . ARG A 1 646 ? 160.914 110.376 185.390 1.00 798.29 ? 646 ARG A NH2   1 
ATOM   5205 N  N     . LYS A 1 647 ? 158.262 105.903 181.036 1.00 800.01 ? 647 LYS A N     1 
ATOM   5206 C  CA    . LYS A 1 647 ? 157.572 104.699 181.482 1.00 800.01 ? 647 LYS A CA    1 
ATOM   5207 C  C     . LYS A 1 647 ? 156.526 104.259 180.465 1.00 800.01 ? 647 LYS A C     1 
ATOM   5208 O  O     . LYS A 1 647 ? 156.361 103.059 180.216 1.00 800.01 ? 647 LYS A O     1 
ATOM   5209 C  CB    . LYS A 1 647 ? 156.936 104.935 182.851 1.00 800.01 ? 647 LYS A CB    1 
ATOM   5210 C  CG    . LYS A 1 647 ? 156.108 106.207 182.942 1.00 800.01 ? 647 LYS A CG    1 
ATOM   5211 C  CD    . LYS A 1 647 ? 155.413 106.326 184.287 1.00 800.01 ? 647 LYS A CD    1 
ATOM   5212 C  CE    . LYS A 1 647 ? 154.778 107.696 184.458 1.00 800.01 ? 647 LYS A CE    1 
ATOM   5213 N  NZ    . LYS A 1 647 ? 153.797 107.990 183.377 1.00 800.01 ? 647 LYS A NZ    1 
ATOM   5214 N  N     . ASN A 1 648 ? 155.810 105.216 179.870 1.00 771.11 ? 648 ASN A N     1 
ATOM   5215 C  CA    . ASN A 1 648 ? 154.834 104.880 178.839 1.00 771.11 ? 648 ASN A CA    1 
ATOM   5216 C  C     . ASN A 1 648 ? 155.507 104.252 177.626 1.00 771.11 ? 648 ASN A C     1 
ATOM   5217 O  O     . ASN A 1 648 ? 155.003 103.273 177.062 1.00 771.11 ? 648 ASN A O     1 
ATOM   5218 C  CB    . ASN A 1 648 ? 154.053 106.129 178.428 1.00 771.11 ? 648 ASN A CB    1 
ATOM   5219 C  CG    . ASN A 1 648 ? 153.433 106.846 179.611 1.00 771.11 ? 648 ASN A CG    1 
ATOM   5220 O  OD1   . ASN A 1 648 ? 153.642 106.464 180.762 1.00 771.11 ? 648 ASN A OD1   1 
ATOM   5221 N  ND2   . ASN A 1 648 ? 152.667 107.895 179.332 1.00 771.11 ? 648 ASN A ND2   1 
ATOM   5222 N  N     . ALA A 1 649 ? 156.648 104.806 177.205 1.00 799.73 ? 649 ALA A N     1 
ATOM   5223 C  CA    . ALA A 1 649 ? 157.369 104.248 176.066 1.00 799.73 ? 649 ALA A CA    1 
ATOM   5224 C  C     . ALA A 1 649 ? 157.889 102.848 176.370 1.00 799.73 ? 649 ALA A C     1 
ATOM   5225 O  O     . ALA A 1 649 ? 157.812 101.954 175.519 1.00 799.73 ? 649 ALA A O     1 
ATOM   5226 C  CB    . ALA A 1 649 ? 158.518 105.173 175.668 1.00 799.73 ? 649 ALA A CB    1 
ATOM   5227 N  N     . GLU A 1 650 ? 158.427 102.641 177.574 1.00 812.62 ? 650 GLU A N     1 
ATOM   5228 C  CA    . GLU A 1 650 ? 158.926 101.319 177.941 1.00 812.62 ? 650 GLU A CA    1 
ATOM   5229 C  C     . GLU A 1 650 ? 157.797 100.299 178.018 1.00 812.62 ? 650 GLU A C     1 
ATOM   5230 O  O     . GLU A 1 650 ? 157.966 99.146  177.601 1.00 812.62 ? 650 GLU A O     1 
ATOM   5231 C  CB    . GLU A 1 650 ? 159.678 101.391 179.270 1.00 812.62 ? 650 GLU A CB    1 
ATOM   5232 C  CG    . GLU A 1 650 ? 161.068 101.998 179.162 1.00 812.62 ? 650 GLU A CG    1 
ATOM   5233 C  CD    . GLU A 1 650 ? 161.425 102.858 180.359 1.00 812.62 ? 650 GLU A CD    1 
ATOM   5234 O  OE1   . GLU A 1 650 ? 160.969 102.541 181.477 1.00 812.62 ? 650 GLU A OE1   1 
ATOM   5235 O  OE2   . GLU A 1 650 ? 162.162 103.850 180.181 1.00 812.62 ? 650 GLU A OE2   1 
ATOM   5236 N  N     . LEU A 1 651 ? 156.641 100.699 178.554 1.00 805.16 ? 651 LEU A N     1 
ATOM   5237 C  CA    . LEU A 1 651 ? 155.510 99.780  178.647 1.00 805.16 ? 651 LEU A CA    1 
ATOM   5238 C  C     . LEU A 1 651 ? 155.004 99.382  177.266 1.00 805.16 ? 651 LEU A C     1 
ATOM   5239 O  O     . LEU A 1 651 ? 154.670 98.215  177.031 1.00 805.16 ? 651 LEU A O     1 
ATOM   5240 C  CB    . LEU A 1 651 ? 154.388 100.412 179.470 1.00 805.16 ? 651 LEU A CB    1 
ATOM   5241 C  CG    . LEU A 1 651 ? 154.572 100.394 180.989 1.00 805.16 ? 651 LEU A CG    1 
ATOM   5242 C  CD1   . LEU A 1 651 ? 153.717 101.465 181.648 1.00 805.16 ? 651 LEU A CD1   1 
ATOM   5243 C  CD2   . LEU A 1 651 ? 154.250 99.019  181.555 1.00 805.16 ? 651 LEU A CD2   1 
ATOM   5244 N  N     . LYS A 1 652 ? 154.939 100.335 176.340 1.00 758.95 ? 652 LYS A N     1 
ATOM   5245 C  CA    . LYS A 1 652 ? 154.474 100.055 174.986 1.00 758.95 ? 652 LYS A CA    1 
ATOM   5246 C  C     . LYS A 1 652 ? 155.556 99.367  174.160 1.00 758.95 ? 652 LYS A C     1 
ATOM   5247 O  O     . LYS A 1 652 ? 156.602 98.981  174.684 1.00 758.95 ? 652 LYS A O     1 
ATOM   5248 C  CB    . LYS A 1 652 ? 154.028 101.346 174.293 1.00 758.95 ? 652 LYS A CB    1 
ATOM   5249 C  CG    . LYS A 1 652 ? 152.644 101.828 174.701 1.00 758.95 ? 652 LYS A CG    1 
ATOM   5250 C  CD    . LYS A 1 652 ? 152.586 103.347 174.773 1.00 758.95 ? 652 LYS A CD    1 
ATOM   5251 C  CE    . LYS A 1 652 ? 152.166 103.949 173.440 1.00 758.95 ? 652 LYS A CE    1 
ATOM   5252 N  NZ    . LYS A 1 652 ? 150.732 103.686 173.132 1.00 758.95 ? 652 LYS A NZ    1 
ATOM   5253 O  "O5'" . A   B 2 1   ? 139.570 155.231 107.245 1.00 1027.2 ? 1   A   B "O5'" 1 
ATOM   5254 C  "C5'" . A   B 2 1   ? 138.738 156.339 107.555 1.00 1027.2 ? 1   A   B "C5'" 1 
ATOM   5255 C  "C4'" . A   B 2 1   ? 137.278 155.965 107.500 1.00 1027.2 ? 1   A   B "C4'" 1 
ATOM   5256 O  "O4'" . A   B 2 1   ? 136.916 155.594 106.146 1.00 1027.2 ? 1   A   B "O4'" 1 
ATOM   5257 C  "C3'" . A   B 2 1   ? 136.866 154.766 108.340 1.00 1027.2 ? 1   A   B "C3'" 1 
ATOM   5258 O  "O3'" . A   B 2 1   ? 136.648 155.106 109.700 1.00 1027.2 ? 1   A   B "O3'" 1 
ATOM   5259 C  "C2'" . A   B 2 1   ? 135.610 154.270 107.632 1.00 1027.2 ? 1   A   B "C2'" 1 
ATOM   5260 O  "O2'" . A   B 2 1   ? 134.482 155.043 108.009 1.00 1027.2 ? 1   A   B "O2'" 1 
ATOM   5261 C  "C1'" . A   B 2 1   ? 135.938 154.576 106.169 1.00 1027.2 ? 1   A   B "C1'" 1 
ATOM   5262 N  N9    . A   B 2 1   ? 136.455 153.406 105.432 1.00 1027.2 ? 1   A   B N9    1 
ATOM   5263 C  C8    . A   B 2 1   ? 137.693 153.280 104.850 1.00 1027.2 ? 1   A   B C8    1 
ATOM   5264 N  N7    . A   B 2 1   ? 137.881 152.135 104.240 1.00 1027.2 ? 1   A   B N7    1 
ATOM   5265 C  C5    . A   B 2 1   ? 136.681 151.461 104.425 1.00 1027.2 ? 1   A   B C5    1 
ATOM   5266 C  C6    . A   B 2 1   ? 136.245 150.188 104.017 1.00 1027.2 ? 1   A   B C6    1 
ATOM   5267 N  N6    . A   B 2 1   ? 136.996 149.341 103.313 1.00 1027.2 ? 1   A   B N6    1 
ATOM   5268 N  N1    . A   B 2 1   ? 134.994 149.810 104.360 1.00 1027.2 ? 1   A   B N1    1 
ATOM   5269 C  C2    . A   B 2 1   ? 134.241 150.663 105.068 1.00 1027.2 ? 1   A   B C2    1 
ATOM   5270 N  N3    . A   B 2 1   ? 134.541 151.885 105.511 1.00 1027.2 ? 1   A   B N3    1 
ATOM   5271 C  C4    . A   B 2 1   ? 135.791 152.232 105.151 1.00 1027.2 ? 1   A   B C4    1 
ATOM   5272 P  P     . U   B 2 2   ? 137.016 154.067 110.869 1.00 1027.2 ? 2   U   B P     1 
ATOM   5273 O  OP1   . U   B 2 2   ? 137.120 154.826 112.142 1.00 1027.2 ? 2   U   B OP1   1 
ATOM   5274 O  OP2   . U   B 2 2   ? 138.163 153.244 110.409 1.00 1027.2 ? 2   U   B OP2   1 
ATOM   5275 O  "O5'" . U   B 2 2   ? 135.738 153.121 110.963 1.00 1027.2 ? 2   U   B "O5'" 1 
ATOM   5276 C  "C5'" . U   B 2 2   ? 134.453 153.647 111.268 1.00 1027.2 ? 2   U   B "C5'" 1 
ATOM   5277 C  "C4'" . U   B 2 2   ? 133.380 152.606 111.075 1.00 1027.2 ? 2   U   B "C4'" 1 
ATOM   5278 O  "O4'" . U   B 2 2   ? 133.312 152.239 109.672 1.00 1027.2 ? 2   U   B "O4'" 1 
ATOM   5279 C  "C3'" . U   B 2 2   ? 133.609 151.287 111.801 1.00 1027.2 ? 2   U   B "C3'" 1 
ATOM   5280 O  "O3'" . U   B 2 2   ? 133.171 151.326 113.148 1.00 1027.2 ? 2   U   B "O3'" 1 
ATOM   5281 C  "C2'" . U   B 2 2   ? 132.849 150.285 110.942 1.00 1027.2 ? 2   U   B "C2'" 1 
ATOM   5282 O  "O2'" . U   B 2 2   ? 131.461 150.325 111.234 1.00 1027.2 ? 2   U   B "O2'" 1 
ATOM   5283 C  "C1'" . U   B 2 2   ? 133.063 150.856 109.541 1.00 1027.2 ? 2   U   B "C1'" 1 
ATOM   5284 N  N1    . U   B 2 2   ? 134.214 150.248 108.832 1.00 1027.2 ? 2   U   B N1    1 
ATOM   5285 C  C2    . U   B 2 2   ? 134.096 148.976 108.299 1.00 1027.2 ? 2   U   B C2    1 
ATOM   5286 O  O2    . U   B 2 2   ? 133.084 148.303 108.400 1.00 1027.2 ? 2   U   B O2    1 
ATOM   5287 N  N3    . U   B 2 2   ? 135.218 148.516 107.649 1.00 1027.2 ? 2   U   B N3    1 
ATOM   5288 C  C4    . U   B 2 2   ? 136.414 149.185 107.472 1.00 1027.2 ? 2   U   B C4    1 
ATOM   5289 O  O4    . U   B 2 2   ? 137.344 148.652 106.865 1.00 1027.2 ? 2   U   B O4    1 
ATOM   5290 C  C5    . U   B 2 2   ? 136.451 150.493 108.043 1.00 1027.2 ? 2   U   B C5    1 
ATOM   5291 C  C6    . U   B 2 2   ? 135.377 150.963 108.680 1.00 1027.2 ? 2   U   B C6    1 
ATOM   5292 P  P     . A   B 2 3   ? 133.880 150.412 114.263 1.00 1027.2 ? 3   A   B P     1 
ATOM   5293 O  OP1   . A   B 2 3   ? 133.425 150.881 115.596 1.00 1027.2 ? 3   A   B OP1   1 
ATOM   5294 O  OP2   . A   B 2 3   ? 135.332 150.359 113.959 1.00 1027.2 ? 3   A   B OP2   1 
ATOM   5295 O  "O5'" . A   B 2 3   ? 133.270 148.961 114.019 1.00 1027.2 ? 3   A   B "O5'" 1 
ATOM   5296 C  "C5'" . A   B 2 3   ? 131.882 148.711 114.188 1.00 1027.2 ? 3   A   B "C5'" 1 
ATOM   5297 C  "C4'" . A   B 2 3   ? 131.520 147.322 113.729 1.00 1027.2 ? 3   A   B "C4'" 1 
ATOM   5298 O  "O4'" . A   B 2 3   ? 131.732 147.214 112.297 1.00 1027.2 ? 3   A   B "O4'" 1 
ATOM   5299 C  "C3'" . A   B 2 3   ? 132.357 146.195 114.319 1.00 1027.2 ? 3   A   B "C3'" 1 
ATOM   5300 O  "O3'" . A   B 2 3   ? 131.899 145.784 115.596 1.00 1027.2 ? 3   A   B "O3'" 1 
ATOM   5301 C  "C2'" . A   B 2 3   ? 132.261 145.110 113.256 1.00 1027.2 ? 3   A   B "C2'" 1 
ATOM   5302 O  "O2'" . A   B 2 3   ? 131.022 144.422 113.351 1.00 1027.2 ? 3   A   B "O2'" 1 
ATOM   5303 C  "C1'" . A   B 2 3   ? 132.251 145.941 111.976 1.00 1027.2 ? 3   A   B "C1'" 1 
ATOM   5304 N  N9    . A   B 2 3   ? 133.602 146.131 111.416 1.00 1027.2 ? 3   A   B N9    1 
ATOM   5305 C  C8    . A   B 2 3   ? 134.352 147.279 111.484 1.00 1027.2 ? 3   A   B C8    1 
ATOM   5306 N  N7    . A   B 2 3   ? 135.515 147.195 110.893 1.00 1027.2 ? 3   A   B N7    1 
ATOM   5307 C  C5    . A   B 2 3   ? 135.535 145.900 110.398 1.00 1027.2 ? 3   A   B C5    1 
ATOM   5308 C  C6    . A   B 2 3   ? 136.505 145.197 109.669 1.00 1027.2 ? 3   A   B C6    1 
ATOM   5309 N  N6    . A   B 2 3   ? 137.674 145.729 109.308 1.00 1027.2 ? 3   A   B N6    1 
ATOM   5310 N  N1    . A   B 2 3   ? 136.231 143.923 109.321 1.00 1027.2 ? 3   A   B N1    1 
ATOM   5311 C  C2    . A   B 2 3   ? 135.055 143.394 109.691 1.00 1027.2 ? 3   A   B C2    1 
ATOM   5312 N  N3    . A   B 2 3   ? 134.060 143.960 110.377 1.00 1027.2 ? 3   A   B N3    1 
ATOM   5313 C  C4    . A   B 2 3   ? 134.364 145.229 110.706 1.00 1027.2 ? 3   A   B C4    1 
ATOM   5314 P  P     . C   B 2 4   ? 132.919 145.133 116.652 1.00 1027.2 ? 4   C   B P     1 
ATOM   5315 O  OP1   . C   B 2 4   ? 132.183 144.933 117.927 1.00 1027.2 ? 4   C   B OP1   1 
ATOM   5316 O  OP2   . C   B 2 4   ? 134.172 145.930 116.645 1.00 1027.2 ? 4   C   B OP2   1 
ATOM   5317 O  "O5'" . C   B 2 4   ? 133.242 143.697 116.041 1.00 1027.2 ? 4   C   B "O5'" 1 
ATOM   5318 C  "C5'" . C   B 2 4   ? 132.229 142.709 115.923 1.00 1027.2 ? 4   C   B "C5'" 1 
ATOM   5319 C  "C4'" . C   B 2 4   ? 132.713 141.518 115.136 1.00 1027.2 ? 4   C   B "C4'" 1 
ATOM   5320 O  "O4'" . C   B 2 4   ? 133.075 141.930 113.791 1.00 1027.2 ? 4   C   B "O4'" 1 
ATOM   5321 C  "C3'" . C   B 2 4   ? 133.968 140.844 115.666 1.00 1027.2 ? 4   C   B "C3'" 1 
ATOM   5322 O  "O3'" . C   B 2 4   ? 133.710 139.961 116.741 1.00 1027.2 ? 4   C   B "O3'" 1 
ATOM   5323 C  "C2'" . C   B 2 4   ? 134.525 140.161 114.425 1.00 1027.2 ? 4   C   B "C2'" 1 
ATOM   5324 O  "O2'" . C   B 2 4   ? 133.813 138.964 114.148 1.00 1027.2 ? 4   C   B "O2'" 1 
ATOM   5325 C  "C1'" . C   B 2 4   ? 134.188 141.185 113.341 1.00 1027.2 ? 4   C   B "C1'" 1 
ATOM   5326 N  N1    . C   B 2 4   ? 135.309 142.123 113.088 1.00 1027.2 ? 4   C   B N1    1 
ATOM   5327 C  C2    . C   B 2 4   ? 136.412 141.705 112.331 1.00 1027.2 ? 4   C   B C2    1 
ATOM   5328 O  O2    . C   B 2 4   ? 136.430 140.546 111.888 1.00 1027.2 ? 4   C   B O2    1 
ATOM   5329 N  N3    . C   B 2 4   ? 137.425 142.577 112.108 1.00 1027.2 ? 4   C   B N3    1 
ATOM   5330 C  C4    . C   B 2 4   ? 137.364 143.815 112.604 1.00 1027.2 ? 4   C   B C4    1 
ATOM   5331 N  N4    . C   B 2 4   ? 138.377 144.651 112.366 1.00 1027.2 ? 4   C   B N4    1 
ATOM   5332 C  C5    . C   B 2 4   ? 136.255 144.265 113.371 1.00 1027.2 ? 4   C   B C5    1 
ATOM   5333 C  C6    . C   B 2 4   ? 135.264 143.395 113.585 1.00 1027.2 ? 4   C   B C6    1 
ATOM   5334 P  P     . G   B 2 5   ? 134.741 139.868 117.970 1.00 1027.2 ? 5   G   B P     1 
ATOM   5335 O  OP1   . G   B 2 5   ? 134.070 139.144 119.081 1.00 1027.2 ? 5   G   B OP1   1 
ATOM   5336 O  OP2   . G   B 2 5   ? 135.296 141.225 118.210 1.00 1027.2 ? 5   G   B OP2   1 
ATOM   5337 O  "O5'" . G   B 2 5   ? 135.913 138.945 117.415 1.00 1027.2 ? 5   G   B "O5'" 1 
ATOM   5338 C  "C5'" . G   B 2 5   ? 135.644 137.631 116.952 1.00 1027.2 ? 5   G   B "C5'" 1 
ATOM   5339 C  "C4'" . G   B 2 5   ? 136.789 137.082 116.139 1.00 1027.2 ? 5   G   B "C4'" 1 
ATOM   5340 O  "O4'" . G   B 2 5   ? 136.915 137.822 114.897 1.00 1027.2 ? 5   G   B "O4'" 1 
ATOM   5341 C  "C3'" . G   B 2 5   ? 138.168 137.188 116.769 1.00 1027.2 ? 5   G   B "C3'" 1 
ATOM   5342 O  "O3'" . G   B 2 5   ? 138.419 136.179 117.731 1.00 1027.2 ? 5   G   B "O3'" 1 
ATOM   5343 C  "C2'" . G   B 2 5   ? 139.088 137.125 115.558 1.00 1027.2 ? 5   G   B "C2'" 1 
ATOM   5344 O  "O2'" . G   B 2 5   ? 139.223 135.788 115.099 1.00 1027.2 ? 5   G   B "O2'" 1 
ATOM   5345 C  "C1'" . G   B 2 5   ? 138.277 137.911 114.526 1.00 1027.2 ? 5   G   B "C1'" 1 
ATOM   5346 N  N9    . G   B 2 5   ? 138.664 139.334 114.494 1.00 1027.2 ? 5   G   B N9    1 
ATOM   5347 C  C8    . G   B 2 5   ? 137.909 140.409 114.891 1.00 1027.2 ? 5   G   B C8    1 
ATOM   5348 N  N7    . G   B 2 5   ? 138.524 141.551 114.748 1.00 1027.2 ? 5   G   B N7    1 
ATOM   5349 C  C5    . G   B 2 5   ? 139.762 141.210 114.221 1.00 1027.2 ? 5   G   B C5    1 
ATOM   5350 C  C6    . G   B 2 5   ? 140.864 142.028 113.860 1.00 1027.2 ? 5   G   B C6    1 
ATOM   5351 O  O6    . G   B 2 5   ? 140.955 143.259 113.929 1.00 1027.2 ? 5   G   B O6    1 
ATOM   5352 N  N1    . G   B 2 5   ? 141.926 141.273 113.371 1.00 1027.2 ? 5   G   B N1    1 
ATOM   5353 C  C2    . G   B 2 5   ? 141.927 139.905 113.250 1.00 1027.2 ? 5   G   B C2    1 
ATOM   5354 N  N2    . G   B 2 5   ? 143.045 139.353 112.757 1.00 1027.2 ? 5   G   B N2    1 
ATOM   5355 N  N3    . G   B 2 5   ? 140.908 139.131 113.585 1.00 1027.2 ? 5   G   B N3    1 
ATOM   5356 C  C4    . G   B 2 5   ? 139.864 139.845 114.059 1.00 1027.2 ? 5   G   B C4    1 
ATOM   5357 P  P     . U   B 2 6   ? 139.330 136.498 119.016 1.00 1027.2 ? 6   U   B P     1 
ATOM   5358 O  OP1   . U   B 2 6   ? 139.200 135.366 119.967 1.00 1027.2 ? 6   U   B OP1   1 
ATOM   5359 O  OP2   . U   B 2 6   ? 139.016 137.877 119.471 1.00 1027.2 ? 6   U   B OP2   1 
ATOM   5360 O  "O5'" . U   B 2 6   ? 140.816 136.494 118.443 1.00 1027.2 ? 6   U   B "O5'" 1 
ATOM   5361 C  "C5'" . U   B 2 6   ? 141.355 135.336 117.823 1.00 1027.2 ? 6   U   B "C5'" 1 
ATOM   5362 C  "C4'" . U   B 2 6   ? 142.715 135.606 117.231 1.00 1027.2 ? 6   U   B "C4'" 1 
ATOM   5363 O  "O4'" . U   B 2 6   ? 142.595 136.523 116.111 1.00 1027.2 ? 6   U   B "O4'" 1 
ATOM   5364 C  "C3'" . U   B 2 6   ? 143.720 136.279 118.152 1.00 1027.2 ? 6   U   B "C3'" 1 
ATOM   5365 O  "O3'" . U   B 2 6   ? 144.345 135.377 119.048 1.00 1027.2 ? 6   U   B "O3'" 1 
ATOM   5366 C  "C2'" . U   B 2 6   ? 144.681 136.932 117.169 1.00 1027.2 ? 6   U   B "C2'" 1 
ATOM   5367 O  "O2'" . U   B 2 6   ? 145.577 135.972 116.630 1.00 1027.2 ? 6   U   B "O2'" 1 
ATOM   5368 C  "C1'" . U   B 2 6   ? 143.722 137.373 116.062 1.00 1027.2 ? 6   U   B "C1'" 1 
ATOM   5369 N  N1    . U   B 2 6   ? 143.267 138.770 116.248 1.00 1027.2 ? 6   U   B N1    1 
ATOM   5370 C  C2    . U   B 2 6   ? 144.155 139.800 115.987 1.00 1027.2 ? 6   U   B C2    1 
ATOM   5371 O  O2    . U   B 2 6   ? 145.302 139.615 115.615 1.00 1027.2 ? 6   U   B O2    1 
ATOM   5372 N  N3    . U   B 2 6   ? 143.654 141.064 116.187 1.00 1027.2 ? 6   U   B N3    1 
ATOM   5373 C  C4    . U   B 2 6   ? 142.382 141.394 116.611 1.00 1027.2 ? 6   U   B C4    1 
ATOM   5374 O  O4    . U   B 2 6   ? 142.061 142.576 116.746 1.00 1027.2 ? 6   U   B O4    1 
ATOM   5375 C  C5    . U   B 2 6   ? 141.526 140.275 116.855 1.00 1027.2 ? 6   U   B C5    1 
ATOM   5376 C  C6    . U   B 2 6   ? 141.985 139.035 116.668 1.00 1027.2 ? 6   U   B C6    1 
ATOM   5377 P  P     . C   B 2 7   ? 144.846 135.887 120.487 1.00 1027.2 ? 7   C   B P     1 
ATOM   5378 O  OP1   . C   B 2 7   ? 145.325 134.705 121.246 1.00 1027.2 ? 7   C   B OP1   1 
ATOM   5379 O  OP2   . C   B 2 7   ? 143.790 136.754 121.071 1.00 1027.2 ? 7   C   B OP2   1 
ATOM   5380 O  "O5'" . C   B 2 7   ? 146.107 136.801 120.153 1.00 1027.2 ? 7   C   B "O5'" 1 
ATOM   5381 C  "C5'" . C   B 2 7   ? 147.300 136.230 119.636 1.00 1027.2 ? 7   C   B "C5'" 1 
ATOM   5382 C  "C4'" . C   B 2 7   ? 148.307 137.289 119.260 1.00 1027.2 ? 7   C   B "C4'" 1 
ATOM   5383 O  "O4'" . C   B 2 7   ? 147.764 138.142 118.219 1.00 1027.2 ? 7   C   B "O4'" 1 
ATOM   5384 C  "C3'" . C   B 2 7   ? 148.700 138.259 120.360 1.00 1027.2 ? 7   C   B "C3'" 1 
ATOM   5385 O  "O3'" . C   B 2 7   ? 149.661 137.726 121.255 1.00 1027.2 ? 7   C   B "O3'" 1 
ATOM   5386 C  "C2'" . C   B 2 7   ? 149.200 139.463 119.575 1.00 1027.2 ? 7   C   B "C2'" 1 
ATOM   5387 O  "O2'" . C   B 2 7   ? 150.516 139.238 119.092 1.00 1027.2 ? 7   C   B "O2'" 1 
ATOM   5388 C  "C1'" . C   B 2 7   ? 148.241 139.463 118.382 1.00 1027.2 ? 7   C   B "C1'" 1 
ATOM   5389 N  N1    . C   B 2 7   ? 147.087 140.366 118.596 1.00 1027.2 ? 7   C   B N1    1 
ATOM   5390 C  C2    . C   B 2 7   ? 147.276 141.750 118.515 1.00 1027.2 ? 7   C   B C2    1 
ATOM   5391 O  O2    . C   B 2 7   ? 148.412 142.190 118.274 1.00 1027.2 ? 7   C   B O2    1 
ATOM   5392 N  N3    . C   B 2 7   ? 146.221 142.575 118.711 1.00 1027.2 ? 7   C   B N3    1 
ATOM   5393 C  C4    . C   B 2 7   ? 145.016 142.068 118.973 1.00 1027.2 ? 7   C   B C4    1 
ATOM   5394 N  N4    . C   B 2 7   ? 144.003 142.917 119.158 1.00 1027.2 ? 7   C   B N4    1 
ATOM   5395 C  C5    . C   B 2 7   ? 144.794 140.664 119.059 1.00 1027.2 ? 7   C   B C5    1 
ATOM   5396 C  C6    . C   B 2 7   ? 145.845 139.859 118.862 1.00 1027.2 ? 7   C   B C6    1 
ATOM   5397 P  P     . C   B 2 8   ? 149.721 138.240 122.777 1.00 1027.2 ? 8   C   B P     1 
ATOM   5398 O  OP1   . C   B 2 8   ? 150.732 137.421 123.492 1.00 1027.2 ? 8   C   B OP1   1 
ATOM   5399 O  OP2   . C   B 2 8   ? 148.333 138.313 123.301 1.00 1027.2 ? 8   C   B OP2   1 
ATOM   5400 O  "O5'" . C   B 2 8   ? 150.286 139.725 122.660 1.00 1027.2 ? 8   C   B "O5'" 1 
ATOM   5401 C  "C5'" . C   B 2 8   ? 151.623 139.964 122.249 1.00 1027.2 ? 8   C   B "C5'" 1 
ATOM   5402 C  "C4'" . C   B 2 8   ? 151.902 141.438 122.090 1.00 1027.2 ? 8   C   B "C4'" 1 
ATOM   5403 O  "O4'" . C   B 2 8   ? 151.026 142.003 121.082 1.00 1027.2 ? 8   C   B "O4'" 1 
ATOM   5404 C  "C3'" . C   B 2 8   ? 151.655 142.300 123.317 1.00 1027.2 ? 8   C   B "C3'" 1 
ATOM   5405 O  "O3'" . C   B 2 8   ? 152.723 142.251 124.248 1.00 1027.2 ? 8   C   B "O3'" 1 
ATOM   5406 C  "C2'" . C   B 2 8   ? 151.436 143.682 122.715 1.00 1027.2 ? 8   C   B "C2'" 1 
ATOM   5407 O  "O2'" . C   B 2 8   ? 152.677 144.288 122.386 1.00 1027.2 ? 8   C   B "O2'" 1 
ATOM   5408 C  "C1'" . C   B 2 8   ? 150.708 143.339 121.414 1.00 1027.2 ? 8   C   B "C1'" 1 
ATOM   5409 N  N1    . C   B 2 8   ? 149.236 143.471 121.525 1.00 1027.2 ? 8   C   B N1    1 
ATOM   5410 C  C2    . C   B 2 8   ? 148.658 144.748 121.534 1.00 1027.2 ? 8   C   B C2    1 
ATOM   5411 O  O2    . C   B 2 8   ? 149.402 145.738 121.467 1.00 1027.2 ? 8   C   B O2    1 
ATOM   5412 N  N3    . C   B 2 8   ? 147.311 144.866 121.622 1.00 1027.2 ? 8   C   B N3    1 
ATOM   5413 C  C4    . C   B 2 8   ? 146.550 143.772 121.691 1.00 1027.2 ? 8   C   B C4    1 
ATOM   5414 N  N4    . C   B 2 8   ? 145.227 143.924 121.777 1.00 1027.2 ? 8   C   B N4    1 
ATOM   5415 C  C5    . C   B 2 8   ? 147.112 142.463 121.680 1.00 1027.2 ? 8   C   B C5    1 
ATOM   5416 C  C6    . C   B 2 8   ? 148.443 142.359 121.591 1.00 1027.2 ? 8   C   B C6    1 
ATOM   5417 P  P     . U   B 2 9   ? 152.450 142.514 125.809 1.00 1027.2 ? 9   U   B P     1 
ATOM   5418 O  OP1   . U   B 2 9   ? 153.703 142.219 126.549 1.00 1027.2 ? 9   U   B OP1   1 
ATOM   5419 O  OP2   . U   B 2 9   ? 151.195 141.816 126.182 1.00 1027.2 ? 9   U   B OP2   1 
ATOM   5420 O  "O5'" . U   B 2 9   ? 152.186 144.083 125.896 1.00 1027.2 ? 9   U   B "O5'" 1 
ATOM   5421 C  "C5'" . U   B 2 9   ? 153.192 145.016 125.528 1.00 1027.2 ? 9   U   B "C5'" 1 
ATOM   5422 C  "C4'" . U   B 2 9   ? 152.670 146.430 125.554 1.00 1027.2 ? 9   U   B "C4'" 1 
ATOM   5423 O  "O4'" . U   B 2 9   ? 151.681 146.612 124.509 1.00 1027.2 ? 9   U   B "O4'" 1 
ATOM   5424 C  "C3'" . U   B 2 9   ? 151.943 146.841 126.824 1.00 1027.2 ? 9   U   B "C3'" 1 
ATOM   5425 O  "O3'" . U   B 2 9   ? 152.828 147.203 127.869 1.00 1027.2 ? 9   U   B "O3'" 1 
ATOM   5426 C  "C2'" . U   B 2 9   ? 151.059 147.985 126.348 1.00 1027.2 ? 9   U   B "C2'" 1 
ATOM   5427 O  "O2'" . U   B 2 9   ? 151.809 149.185 126.230 1.00 1027.2 ? 9   U   B "O2'" 1 
ATOM   5428 C  "C1'" . U   B 2 9   ? 150.682 147.514 124.943 1.00 1027.2 ? 9   U   B "C1'" 1 
ATOM   5429 N  N1    . U   B 2 9   ? 149.370 146.824 124.902 1.00 1027.2 ? 9   U   B N1    1 
ATOM   5430 C  C2    . U   B 2 9   ? 148.223 147.595 124.927 1.00 1027.2 ? 9   U   B C2    1 
ATOM   5431 O  O2    . U   B 2 9   ? 148.242 148.812 124.994 1.00 1027.2 ? 9   U   B O2    1 
ATOM   5432 N  N3    . U   B 2 9   ? 147.044 146.890 124.877 1.00 1027.2 ? 9   U   B N3    1 
ATOM   5433 C  C4    . U   B 2 9   ? 146.900 145.519 124.800 1.00 1027.2 ? 9   U   B C4    1 
ATOM   5434 O  O4    . U   B 2 9   ? 145.775 145.016 124.760 1.00 1027.2 ? 9   U   B O4    1 
ATOM   5435 C  C5    . U   B 2 9   ? 148.132 144.794 124.775 1.00 1027.2 ? 9   U   B C5    1 
ATOM   5436 C  C6    . U   B 2 9   ? 149.293 145.454 124.822 1.00 1027.2 ? 9   U   B C6    1 
ATOM   5437 P  P     . G   B 2 10  ? 152.436 146.900 129.397 1.00 1027.2 ? 10  G   B P     1 
ATOM   5438 O  OP1   . G   B 2 10  ? 153.647 147.114 130.230 1.00 1027.2 ? 10  G   B OP1   1 
ATOM   5439 O  OP2   . G   B 2 10  ? 151.735 145.590 129.443 1.00 1027.2 ? 10  G   B OP2   1 
ATOM   5440 O  "O5'" . G   B 2 10  ? 151.382 148.039 129.752 1.00 1027.2 ? 10  G   B "O5'" 1 
ATOM   5441 C  "C5'" . G   B 2 10  ? 151.756 149.408 129.716 1.00 1027.2 ? 10  G   B "C5'" 1 
ATOM   5442 C  "C4'" . G   B 2 10  ? 150.554 150.316 129.777 1.00 1027.2 ? 10  G   B "C4'" 1 
ATOM   5443 O  "O4'" . G   B 2 10  ? 149.755 150.165 128.575 1.00 1027.2 ? 10  G   B "O4'" 1 
ATOM   5444 C  "C3'" . G   B 2 10  ? 149.569 150.051 130.904 1.00 1027.2 ? 10  G   B "C3'" 1 
ATOM   5445 O  "O3'" . G   B 2 10  ? 149.989 150.581 132.148 1.00 1027.2 ? 10  G   B "O3'" 1 
ATOM   5446 C  "C2'" . G   B 2 10  ? 148.287 150.676 130.373 1.00 1027.2 ? 10  G   B "C2'" 1 
ATOM   5447 O  "O2'" . G   B 2 10  ? 148.318 152.089 130.525 1.00 1027.2 ? 10  G   B "O2'" 1 
ATOM   5448 C  "C1'" . G   B 2 10  ? 148.388 150.350 128.882 1.00 1027.2 ? 10  G   B "C1'" 1 
ATOM   5449 N  N9    . G   B 2 10  ? 147.647 149.122 128.535 1.00 1027.2 ? 10  G   B N9    1 
ATOM   5450 C  C8    . G   B 2 10  ? 148.161 147.896 128.189 1.00 1027.2 ? 10  G   B C8    1 
ATOM   5451 N  N7    . G   B 2 10  ? 147.238 147.007 127.937 1.00 1027.2 ? 10  G   B N7    1 
ATOM   5452 C  C5    . G   B 2 10  ? 146.042 147.687 128.127 1.00 1027.2 ? 10  G   B C5    1 
ATOM   5453 C  C6    . G   B 2 10  ? 144.698 147.244 128.007 1.00 1027.2 ? 10  G   B C6    1 
ATOM   5454 O  O6    . G   B 2 10  ? 144.288 146.123 127.683 1.00 1027.2 ? 10  G   B O6    1 
ATOM   5455 N  N1    . G   B 2 10  ? 143.793 148.266 128.291 1.00 1027.2 ? 10  G   B N1    1 
ATOM   5456 C  C2    . G   B 2 10  ? 144.142 149.544 128.653 1.00 1027.2 ? 10  G   B C2    1 
ATOM   5457 N  N2    . G   B 2 10  ? 143.137 150.396 128.896 1.00 1027.2 ? 10  G   B N2    1 
ATOM   5458 N  N3    . G   B 2 10  ? 145.389 149.965 128.773 1.00 1027.2 ? 10  G   B N3    1 
ATOM   5459 C  C4    . G   B 2 10  ? 146.281 148.992 128.496 1.00 1027.2 ? 10  G   B C4    1 
ATOM   5460 P  P     . A   B 2 11  ? 149.563 149.855 133.516 1.00 1027.2 ? 11  A   B P     1 
ATOM   5461 O  OP1   . A   B 2 11  ? 150.355 150.452 134.622 1.00 1027.2 ? 11  A   B OP1   1 
ATOM   5462 O  OP2   . A   B 2 11  ? 149.609 148.388 133.290 1.00 1027.2 ? 11  A   B OP2   1 
ATOM   5463 O  "O5'" . A   B 2 11  ? 148.039 150.275 133.718 1.00 1027.2 ? 11  A   B "O5'" 1 
ATOM   5464 C  "C5'" . A   B 2 11  ? 147.676 151.638 133.885 1.00 1027.2 ? 11  A   B "C5'" 1 
ATOM   5465 C  "C4'" . A   B 2 11  ? 146.186 151.836 133.768 1.00 1027.2 ? 11  A   B "C4'" 1 
ATOM   5466 O  "O4'" . A   B 2 11  ? 145.736 151.455 132.441 1.00 1027.2 ? 11  A   B "O4'" 1 
ATOM   5467 C  "C3'" . A   B 2 11  ? 145.322 151.002 134.701 1.00 1027.2 ? 11  A   B "C3'" 1 
ATOM   5468 O  "O3'" . A   B 2 11  ? 145.243 151.536 136.011 1.00 1027.2 ? 11  A   B "O3'" 1 
ATOM   5469 C  "C2'" . A   B 2 11  ? 143.985 150.971 133.972 1.00 1027.2 ? 11  A   B "C2'" 1 
ATOM   5470 O  "O2'" . A   B 2 11  ? 143.282 152.190 134.161 1.00 1027.2 ? 11  A   B "O2'" 1 
ATOM   5471 C  "C1'" . A   B 2 11  ? 144.440 150.897 132.515 1.00 1027.2 ? 11  A   B "C1'" 1 
ATOM   5472 N  N9    . A   B 2 11  ? 144.495 149.506 132.023 1.00 1027.2 ? 11  A   B N9    1 
ATOM   5473 C  C8    . A   B 2 11  ? 145.609 148.759 131.731 1.00 1027.2 ? 11  A   B C8    1 
ATOM   5474 N  N7    . A   B 2 11  ? 145.336 147.547 131.311 1.00 1027.2 ? 11  A   B N7    1 
ATOM   5475 C  C5    . A   B 2 11  ? 143.949 147.492 131.330 1.00 1027.2 ? 11  A   B C5    1 
ATOM   5476 C  C6    . A   B 2 11  ? 143.038 146.475 130.995 1.00 1027.2 ? 11  A   B C6    1 
ATOM   5477 N  N6    . A   B 2 11  ? 143.405 145.268 130.560 1.00 1027.2 ? 11  A   B N6    1 
ATOM   5478 N  N1    . A   B 2 11  ? 141.719 146.742 131.122 1.00 1027.2 ? 11  A   B N1    1 
ATOM   5479 C  C2    . A   B 2 11  ? 141.352 147.954 131.559 1.00 1027.2 ? 11  A   B C2    1 
ATOM   5480 N  N3    . A   B 2 11  ? 142.114 148.990 131.904 1.00 1027.2 ? 11  A   B N3    1 
ATOM   5481 C  C4    . A   B 2 11  ? 143.417 148.693 131.764 1.00 1027.2 ? 11  A   B C4    1 
ATOM   5482 P  P     . U   B 2 12  ? 145.044 150.558 137.271 1.00 1027.2 ? 12  U   B P     1 
ATOM   5483 O  OP1   . U   B 2 12  ? 145.265 151.350 138.508 1.00 1027.2 ? 12  U   B OP1   1 
ATOM   5484 O  OP2   . U   B 2 12  ? 145.847 149.333 137.032 1.00 1027.2 ? 12  U   B OP2   1 
ATOM   5485 O  "O5'" . U   B 2 12  ? 143.503 150.157 137.211 1.00 1027.2 ? 12  U   B "O5'" 1 
ATOM   5486 C  "C5'" . U   B 2 12  ? 142.488 151.141 137.334 1.00 1027.2 ? 12  U   B "C5'" 1 
ATOM   5487 C  "C4'" . U   B 2 12  ? 141.123 150.572 137.034 1.00 1027.2 ? 12  U   B "C4'" 1 
ATOM   5488 O  "O4'" . U   B 2 12  ? 141.077 150.101 135.661 1.00 1027.2 ? 12  U   B "O4'" 1 
ATOM   5489 C  "C3'" . U   B 2 12  ? 140.711 149.359 137.854 1.00 1027.2 ? 12  U   B "C3'" 1 
ATOM   5490 O  "O3'" . U   B 2 12  ? 140.222 149.697 139.140 1.00 1027.2 ? 12  U   B "O3'" 1 
ATOM   5491 C  "C2'" . U   B 2 12  ? 139.673 148.694 136.961 1.00 1027.2 ? 12  U   B "C2'" 1 
ATOM   5492 O  "O2'" . U   B 2 12  ? 138.427 149.369 137.053 1.00 1027.2 ? 12  U   B "O2'" 1 
ATOM   5493 C  "C1'" . U   B 2 12  ? 140.261 148.952 135.573 1.00 1027.2 ? 12  U   B "C1'" 1 
ATOM   5494 N  N1    . U   B 2 12  ? 141.090 147.820 135.097 1.00 1027.2 ? 12  U   B N1    1 
ATOM   5495 C  C2    . U   B 2 12  ? 140.452 146.667 134.674 1.00 1027.2 ? 12  U   B C2    1 
ATOM   5496 O  O2    . U   B 2 12  ? 139.240 146.534 134.680 1.00 1027.2 ? 12  U   B O2    1 
ATOM   5497 N  N3    . U   B 2 12  ? 141.288 145.661 134.250 1.00 1027.2 ? 12  U   B N3    1 
ATOM   5498 C  C4    . U   B 2 12  ? 142.667 145.694 134.199 1.00 1027.2 ? 12  U   B C4    1 
ATOM   5499 O  O4    . U   B 2 12  ? 143.293 144.714 133.791 1.00 1027.2 ? 12  U   B O4    1 
ATOM   5500 C  C5    . U   B 2 12  ? 143.249 146.921 134.649 1.00 1027.2 ? 12  U   B C5    1 
ATOM   5501 C  C6    . U   B 2 12  ? 142.461 147.915 135.069 1.00 1027.2 ? 12  U   B C6    1 
ATOM   5502 P  P     . A   B 2 13  ? 140.519 148.736 140.395 1.00 992.63 ? 13  A   B P     1 
ATOM   5503 O  OP1   . A   B 2 13  ? 140.145 149.469 141.631 1.00 992.63 ? 13  A   B OP1   1 
ATOM   5504 O  OP2   . A   B 2 13  ? 141.895 148.200 140.249 1.00 992.63 ? 13  A   B OP2   1 
ATOM   5505 O  "O5'" . A   B 2 13  ? 139.495 147.528 140.211 1.00 992.63 ? 13  A   B "O5'" 1 
ATOM   5506 C  "C5'" . A   B 2 13  ? 138.099 147.722 140.391 1.00 992.63 ? 13  A   B "C5'" 1 
ATOM   5507 C  "C4'" . A   B 2 13  ? 137.310 146.504 139.976 1.00 992.63 ? 13  A   B "C4'" 1 
ATOM   5508 O  "O4'" . A   B 2 13  ? 137.458 146.282 138.550 1.00 992.63 ? 13  A   B "O4'" 1 
ATOM   5509 C  "C3'" . A   B 2 13  ? 137.734 145.185 140.602 1.00 992.63 ? 13  A   B "C3'" 1 
ATOM   5510 O  "O3'" . A   B 2 13  ? 137.218 145.002 141.910 1.00 992.63 ? 13  A   B "O3'" 1 
ATOM   5511 C  "C2'" . A   B 2 13  ? 137.223 144.162 139.595 1.00 992.63 ? 13  A   B "C2'" 1 
ATOM   5512 O  "O2'" . A   B 2 13  ? 135.826 143.960 139.752 1.00 992.63 ? 13  A   B "O2'" 1 
ATOM   5513 C  "C1'" . A   B 2 13  ? 137.460 144.897 138.275 1.00 992.63 ? 13  A   B "C1'" 1 
ATOM   5514 N  N9    . A   B 2 13  ? 138.759 144.540 137.674 1.00 992.63 ? 13  A   B N9    1 
ATOM   5515 C  C8    . A   B 2 13  ? 139.883 145.324 137.607 1.00 992.63 ? 13  A   B C8    1 
ATOM   5516 N  N7    . A   B 2 13  ? 140.898 144.746 137.016 1.00 992.63 ? 13  A   B N7    1 
ATOM   5517 C  C5    . A   B 2 13  ? 140.410 143.496 136.670 1.00 992.63 ? 13  A   B C5    1 
ATOM   5518 C  C6    . A   B 2 13  ? 141.003 142.404 136.014 1.00 992.63 ? 13  A   B C6    1 
ATOM   5519 N  N6    . A   B 2 13  ? 142.264 142.410 135.579 1.00 992.63 ? 13  A   B N6    1 
ATOM   5520 N  N1    . A   B 2 13  ? 140.252 141.300 135.819 1.00 992.63 ? 13  A   B N1    1 
ATOM   5521 C  C2    . A   B 2 13  ? 138.984 141.302 136.257 1.00 992.63 ? 13  A   B C2    1 
ATOM   5522 N  N3    . A   B 2 13  ? 138.317 142.267 136.891 1.00 992.63 ? 13  A   B N3    1 
ATOM   5523 C  C4    . A   B 2 13  ? 139.093 143.352 137.067 1.00 992.63 ? 13  A   B C4    1 
ATOM   5524 P  P     . G   B 2 14  ? 138.015 144.101 142.977 1.00 793.69 ? 14  G   B P     1 
ATOM   5525 O  OP1   . G   B 2 14  ? 137.355 144.265 144.297 1.00 793.69 ? 14  G   B OP1   1 
ATOM   5526 O  OP2   . G   B 2 14  ? 139.465 144.390 142.839 1.00 793.69 ? 14  G   B OP2   1 
ATOM   5527 O  "O5'" . G   B 2 14  ? 137.761 142.607 142.486 1.00 793.69 ? 14  G   B "O5'" 1 
ATOM   5528 C  "C5'" . G   B 2 14  ? 136.460 142.039 142.522 1.00 793.69 ? 14  G   B "C5'" 1 
ATOM   5529 C  "C4'" . G   B 2 14  ? 136.417 140.709 141.812 1.00 793.69 ? 14  G   B "C4'" 1 
ATOM   5530 O  "O4'" . G   B 2 14  ? 136.774 140.882 140.416 1.00 793.69 ? 14  G   B "O4'" 1 
ATOM   5531 C  "C3'" . G   B 2 14  ? 137.391 139.655 142.314 1.00 793.69 ? 14  G   B "C3'" 1 
ATOM   5532 O  "O3'" . G   B 2 14  ? 136.929 138.984 143.473 1.00 793.69 ? 14  G   B "O3'" 1 
ATOM   5533 C  "C2'" . G   B 2 14  ? 137.548 138.743 141.103 1.00 793.69 ? 14  G   B "C2'" 1 
ATOM   5534 O  "O2'" . G   B 2 14  ? 136.439 137.864 140.989 1.00 793.69 ? 14  G   B "O2'" 1 
ATOM   5535 C  "C1'" . G   B 2 14  ? 137.486 139.753 139.956 1.00 793.69 ? 14  G   B "C1'" 1 
ATOM   5536 N  N9    . G   B 2 14  ? 138.829 140.186 139.525 1.00 793.69 ? 14  G   B N9    1 
ATOM   5537 C  C8    . G   B 2 14  ? 139.387 141.428 139.702 1.00 793.69 ? 14  G   B C8    1 
ATOM   5538 N  N7    . G   B 2 14  ? 140.592 141.523 139.211 1.00 793.69 ? 14  G   B N7    1 
ATOM   5539 C  C5    . G   B 2 14  ? 140.846 140.266 138.680 1.00 793.69 ? 14  G   B C5    1 
ATOM   5540 C  C6    . G   B 2 14  ? 141.996 139.771 138.016 1.00 793.69 ? 14  G   B C6    1 
ATOM   5541 O  O6    . G   B 2 14  ? 143.044 140.374 137.762 1.00 793.69 ? 14  G   B O6    1 
ATOM   5542 N  N1    . G   B 2 14  ? 141.838 138.440 137.637 1.00 793.69 ? 14  G   B N1    1 
ATOM   5543 C  C2    . G   B 2 14  ? 140.714 137.687 137.871 1.00 793.69 ? 14  G   B C2    1 
ATOM   5544 N  N2    . G   B 2 14  ? 140.740 136.420 137.435 1.00 793.69 ? 14  G   B N2    1 
ATOM   5545 N  N3    . G   B 2 14  ? 139.634 138.139 138.489 1.00 793.69 ? 14  G   B N3    1 
ATOM   5546 C  C4    . G   B 2 14  ? 139.767 139.429 138.863 1.00 793.69 ? 14  G   B C4    1 
ATOM   5547 P  P     . U   B 2 15  ? 137.975 138.445 144.565 1.00 666.16 ? 15  U   B P     1 
ATOM   5548 O  OP1   . U   B 2 15  ? 137.205 137.956 145.736 1.00 666.16 ? 15  U   B OP1   1 
ATOM   5549 O  OP2   . U   B 2 15  ? 139.017 139.487 144.755 1.00 666.16 ? 15  U   B OP2   1 
ATOM   5550 O  "O5'" . U   B 2 15  ? 138.655 137.188 143.860 1.00 666.16 ? 15  U   B "O5'" 1 
ATOM   5551 C  "C5'" . U   B 2 15  ? 137.883 136.056 143.487 1.00 666.16 ? 15  U   B "C5'" 1 
ATOM   5552 C  "C4'" . U   B 2 15  ? 138.695 135.068 142.688 1.00 666.16 ? 15  U   B "C4'" 1 
ATOM   5553 O  "O4'" . U   B 2 15  ? 139.085 135.655 141.420 1.00 666.16 ? 15  U   B "O4'" 1 
ATOM   5554 C  "C3'" . U   B 2 15  ? 140.010 134.630 143.309 1.00 666.16 ? 15  U   B "C3'" 1 
ATOM   5555 O  "O3'" . U   B 2 15  ? 139.853 133.631 144.301 1.00 666.16 ? 15  U   B "O3'" 1 
ATOM   5556 C  "C2'" . U   B 2 15  ? 140.808 134.166 142.098 1.00 666.16 ? 15  U   B "C2'" 1 
ATOM   5557 O  "O2'" . U   B 2 15  ? 140.394 132.871 141.690 1.00 666.16 ? 15  U   B "O2'" 1 
ATOM   5558 C  "C1'" . U   B 2 15  ? 140.358 135.171 141.038 1.00 666.16 ? 15  U   B "C1'" 1 
ATOM   5559 N  N1    . U   B 2 15  ? 141.288 136.317 140.923 1.00 666.16 ? 15  U   B N1    1 
ATOM   5560 C  C2    . U   B 2 15  ? 142.499 136.118 140.281 1.00 666.16 ? 15  U   B C2    1 
ATOM   5561 O  O2    . U   B 2 15  ? 142.837 135.044 139.814 1.00 666.16 ? 15  U   B O2    1 
ATOM   5562 N  N3    . U   B 2 15  ? 143.309 137.225 140.209 1.00 666.16 ? 15  U   B N3    1 
ATOM   5563 C  C4    . U   B 2 15  ? 143.032 138.484 140.705 1.00 666.16 ? 15  U   B C4    1 
ATOM   5564 O  O4    . U   B 2 15  ? 143.851 139.394 140.568 1.00 666.16 ? 15  U   B O4    1 
ATOM   5565 C  C5    . U   B 2 15  ? 141.762 138.607 141.350 1.00 666.16 ? 15  U   B C5    1 
ATOM   5566 C  C6    . U   B 2 15  ? 140.954 137.548 141.432 1.00 666.16 ? 15  U   B C6    1 
ATOM   5567 P  P     . U   B 2 16  ? 140.912 133.518 145.504 1.00 551.24 ? 16  U   B P     1 
ATOM   5568 O  OP1   . U   B 2 16  ? 140.400 132.518 146.475 1.00 551.24 ? 16  U   B OP1   1 
ATOM   5569 O  OP2   . U   B 2 16  ? 141.229 134.894 145.964 1.00 551.24 ? 16  U   B OP2   1 
ATOM   5570 O  "O5'" . U   B 2 16  ? 142.215 132.915 144.814 1.00 551.24 ? 16  U   B "O5'" 1 
ATOM   5571 C  "C5'" . U   B 2 16  ? 142.183 131.645 144.181 1.00 551.24 ? 16  U   B "C5'" 1 
ATOM   5572 C  "C4'" . U   B 2 16  ? 143.453 131.374 143.414 1.00 551.24 ? 16  U   B "C4'" 1 
ATOM   5573 O  "O4'" . U   B 2 16  ? 143.577 132.302 142.305 1.00 551.24 ? 16  U   B "O4'" 1 
ATOM   5574 C  "C3'" . U   B 2 16  ? 144.748 131.556 144.185 1.00 551.24 ? 16  U   B "C3'" 1 
ATOM   5575 O  "O3'" . U   B 2 16  ? 145.053 130.460 145.028 1.00 551.24 ? 16  U   B "O3'" 1 
ATOM   5576 C  "C2'" . U   B 2 16  ? 145.764 131.777 143.072 1.00 551.24 ? 16  U   B "C2'" 1 
ATOM   5577 O  "O2'" . U   B 2 16  ? 146.115 130.545 142.461 1.00 551.24 ? 16  U   B "O2'" 1 
ATOM   5578 C  "C1'" . U   B 2 16  ? 144.941 132.595 142.075 1.00 551.24 ? 16  U   B "C1'" 1 
ATOM   5579 N  N1    . U   B 2 16  ? 145.153 134.053 142.239 1.00 551.24 ? 16  U   B N1    1 
ATOM   5580 C  C2    . U   B 2 16  ? 146.327 134.603 141.752 1.00 551.24 ? 16  U   B C2    1 
ATOM   5581 O  O2    . U   B 2 16  ? 147.192 133.944 141.200 1.00 551.24 ? 16  U   B O2    1 
ATOM   5582 N  N3    . U   B 2 16  ? 146.460 135.958 141.938 1.00 551.24 ? 16  U   B N3    1 
ATOM   5583 C  C4    . U   B 2 16  ? 145.553 136.803 142.548 1.00 551.24 ? 16  U   B C4    1 
ATOM   5584 O  O4    . U   B 2 16  ? 145.799 138.006 142.647 1.00 551.24 ? 16  U   B O4    1 
ATOM   5585 C  C5    . U   B 2 16  ? 144.367 136.158 143.022 1.00 551.24 ? 16  U   B C5    1 
ATOM   5586 C  C6    . U   B 2 16  ? 144.212 134.842 142.855 1.00 551.24 ? 16  U   B C6    1 
ATOM   5587 P  P     . A   B 2 17  ? 145.880 130.700 146.384 1.00 432.34 ? 17  A   B P     1 
ATOM   5588 O  OP1   . A   B 2 17  ? 145.793 129.465 147.205 1.00 432.34 ? 17  A   B OP1   1 
ATOM   5589 O  OP2   . A   B 2 17  ? 145.445 131.997 146.961 1.00 432.34 ? 17  A   B OP2   1 
ATOM   5590 O  "O5'" . A   B 2 17  ? 147.385 130.859 145.888 1.00 432.34 ? 17  A   B "O5'" 1 
ATOM   5591 C  "C5'" . A   B 2 17  ? 148.012 129.835 145.130 1.00 432.34 ? 17  A   B "C5'" 1 
ATOM   5592 C  "C4'" . A   B 2 17  ? 149.332 130.295 144.568 1.00 432.34 ? 17  A   B "C4'" 1 
ATOM   5593 O  "O4'" . A   B 2 17  ? 149.113 131.262 143.507 1.00 432.34 ? 17  A   B "O4'" 1 
ATOM   5594 C  "C3'" . A   B 2 17  ? 150.249 131.021 145.537 1.00 432.34 ? 17  A   B "C3'" 1 
ATOM   5595 O  "O3'" . A   B 2 17  ? 150.958 130.149 146.396 1.00 432.34 ? 17  A   B "O3'" 1 
ATOM   5596 C  "C2'" . A   B 2 17  ? 151.140 131.826 144.603 1.00 432.34 ? 17  A   B "C2'" 1 
ATOM   5597 O  "O2'" . A   B 2 17  ? 152.125 130.995 144.010 1.00 432.34 ? 17  A   B "O2'" 1 
ATOM   5598 C  "C1'" . A   B 2 17  ? 150.140 132.233 143.523 1.00 432.34 ? 17  A   B "C1'" 1 
ATOM   5599 N  N9    . A   B 2 17  ? 149.538 133.549 143.805 1.00 432.34 ? 17  A   B N9    1 
ATOM   5600 C  C8    . A   B 2 17  ? 148.256 133.804 144.222 1.00 432.34 ? 17  A   B C8    1 
ATOM   5601 N  N7    . A   B 2 17  ? 147.996 135.077 144.394 1.00 432.34 ? 17  A   B N7    1 
ATOM   5602 C  C5    . A   B 2 17  ? 149.191 135.702 144.072 1.00 432.34 ? 17  A   B C5    1 
ATOM   5603 C  C6    . A   B 2 17  ? 149.571 137.054 144.061 1.00 432.34 ? 17  A   B C6    1 
ATOM   5604 N  N6    . A   B 2 17  ? 148.745 138.050 144.384 1.00 432.34 ? 17  A   B N6    1 
ATOM   5605 N  N1    . A   B 2 17  ? 150.834 137.352 143.688 1.00 432.34 ? 17  A   B N1    1 
ATOM   5606 C  C2    . A   B 2 17  ? 151.660 136.347 143.361 1.00 432.34 ? 17  A   B C2    1 
ATOM   5607 N  N3    . A   B 2 17  ? 151.419 135.036 143.338 1.00 432.34 ? 17  A   B N3    1 
ATOM   5608 C  C4    . A   B 2 17  ? 150.151 134.776 143.707 1.00 432.34 ? 17  A   B C4    1 
ATOM   5609 P  P     . G   B 2 18  ? 151.299 130.609 147.897 1.00 343.36 ? 18  G   B P     1 
ATOM   5610 O  OP1   . G   B 2 18  ? 151.743 129.417 148.662 1.00 343.36 ? 18  G   B OP1   1 
ATOM   5611 O  OP2   . G   B 2 18  ? 150.154 131.414 148.393 1.00 343.36 ? 18  G   B OP2   1 
ATOM   5612 O  "O5'" . G   B 2 18  ? 152.548 131.582 147.721 1.00 343.36 ? 18  G   B "O5'" 1 
ATOM   5613 C  "C5'" . G   B 2 18  ? 153.702 131.158 147.011 1.00 343.36 ? 18  G   B "C5'" 1 
ATOM   5614 C  "C4'" . G   B 2 18  ? 154.549 132.326 146.574 1.00 343.36 ? 18  G   B "C4'" 1 
ATOM   5615 O  "O4'" . G   B 2 18  ? 153.799 133.177 145.669 1.00 343.36 ? 18  G   B "O4'" 1 
ATOM   5616 C  "C3'" . G   B 2 18  ? 154.999 133.273 147.672 1.00 343.36 ? 18  G   B "C3'" 1 
ATOM   5617 O  "O3'" . G   B 2 18  ? 156.110 132.782 148.399 1.00 343.36 ? 18  G   B "O3'" 1 
ATOM   5618 C  "C2'" . G   B 2 18  ? 155.288 134.557 146.905 1.00 343.36 ? 18  G   B "C2'" 1 
ATOM   5619 O  "O2'" . G   B 2 18  ? 156.554 134.484 146.265 1.00 343.36 ? 18  G   B "O2'" 1 
ATOM   5620 C  "C1'" . G   B 2 18  ? 154.204 134.522 145.831 1.00 343.36 ? 18  G   B "C1'" 1 
ATOM   5621 N  N9    . G   B 2 18  ? 153.031 135.343 146.187 1.00 343.36 ? 18  G   B N9    1 
ATOM   5622 C  C8    . G   B 2 18  ? 151.762 134.911 146.483 1.00 343.36 ? 18  G   B C8    1 
ATOM   5623 N  N7    . G   B 2 18  ? 150.937 135.889 146.747 1.00 343.36 ? 18  G   B N7    1 
ATOM   5624 C  C5    . G   B 2 18  ? 151.707 137.036 146.613 1.00 343.36 ? 18  G   B C5    1 
ATOM   5625 C  C6    . G   B 2 18  ? 151.360 138.402 146.777 1.00 343.36 ? 18  G   B C6    1 
ATOM   5626 O  O6    . G   B 2 18  ? 150.259 138.877 147.080 1.00 343.36 ? 18  G   B O6    1 
ATOM   5627 N  N1    . G   B 2 18  ? 152.445 139.242 146.546 1.00 343.36 ? 18  G   B N1    1 
ATOM   5628 C  C2    . G   B 2 18  ? 153.705 138.816 146.203 1.00 343.36 ? 18  G   B C2    1 
ATOM   5629 N  N2    . G   B 2 18  ? 154.632 139.765 146.018 1.00 343.36 ? 18  G   B N2    1 
ATOM   5630 N  N3    . G   B 2 18  ? 154.040 137.546 146.046 1.00 343.36 ? 18  G   B N3    1 
ATOM   5631 C  C4    . G   B 2 18  ? 153.001 136.716 146.267 1.00 343.36 ? 18  G   B C4    1 
ATOM   5632 P  P     . U   B 2 19  ? 156.297 133.173 149.946 1.00 278.08 ? 19  U   B P     1 
ATOM   5633 O  OP1   . U   B 2 19  ? 157.454 132.410 150.477 1.00 278.08 ? 19  U   B OP1   1 
ATOM   5634 O  OP2   . U   B 2 19  ? 154.974 133.058 150.611 1.00 278.08 ? 19  U   B OP2   1 
ATOM   5635 O  "O5'" . U   B 2 19  ? 156.699 134.713 149.904 1.00 278.08 ? 19  U   B "O5'" 1 
ATOM   5636 C  "C5'" . U   B 2 19  ? 157.839 135.147 149.177 1.00 278.08 ? 19  U   B "C5'" 1 
ATOM   5637 C  "C4'" . U   B 2 19  ? 157.950 136.650 149.168 1.00 278.08 ? 19  U   B "C4'" 1 
ATOM   5638 O  "O4'" . U   B 2 19  ? 156.901 137.234 148.352 1.00 278.08 ? 19  U   B "O4'" 1 
ATOM   5639 C  "C3'" . U   B 2 19  ? 157.782 137.332 150.511 1.00 278.08 ? 19  U   B "C3'" 1 
ATOM   5640 O  "O3'" . U   B 2 19  ? 158.943 137.249 151.318 1.00 278.08 ? 19  U   B "O3'" 1 
ATOM   5641 C  "C2'" . U   B 2 19  ? 157.404 138.753 150.113 1.00 278.08 ? 19  U   B "C2'" 1 
ATOM   5642 O  "O2'" . U   B 2 19  ? 158.553 139.488 149.717 1.00 278.08 ? 19  U   B "O2'" 1 
ATOM   5643 C  "C1'" . U   B 2 19  ? 156.542 138.500 148.873 1.00 278.08 ? 19  U   B "C1'" 1 
ATOM   5644 N  N1    . U   B 2 19  ? 155.095 138.505 149.188 1.00 278.08 ? 19  U   B N1    1 
ATOM   5645 C  C2    . U   B 2 19  ? 154.481 139.735 149.352 1.00 278.08 ? 19  U   B C2    1 
ATOM   5646 O  O2    . U   B 2 19  ? 155.076 140.793 149.248 1.00 278.08 ? 19  U   B O2    1 
ATOM   5647 N  N3    . U   B 2 19  ? 153.141 139.687 149.643 1.00 278.08 ? 19  U   B N3    1 
ATOM   5648 C  C4    . U   B 2 19  ? 152.368 138.553 149.786 1.00 278.08 ? 19  U   B C4    1 
ATOM   5649 O  O4    . U   B 2 19  ? 151.169 138.657 150.047 1.00 278.08 ? 19  U   B O4    1 
ATOM   5650 C  C5    . U   B 2 19  ? 153.075 137.323 149.601 1.00 278.08 ? 19  U   B C5    1 
ATOM   5651 C  C6    . U   B 2 19  ? 154.380 137.339 149.316 1.00 278.08 ? 19  U   B C6    1 
ATOM   5652 P  P     . A   B 2 20  ? 158.800 137.083 152.908 1.00 215.18 ? 20  A   B P     1 
ATOM   5653 O  OP1   . A   B 2 20  ? 160.110 136.633 153.446 1.00 215.18 ? 20  A   B OP1   1 
ATOM   5654 O  OP2   . A   B 2 20  ? 157.580 136.282 153.182 1.00 215.18 ? 20  A   B OP2   1 
ATOM   5655 O  "O5'" . A   B 2 20  ? 158.540 138.569 153.411 1.00 215.18 ? 20  A   B "O5'" 1 
ATOM   5656 C  "C5'" . A   B 2 20  ? 159.360 139.634 152.956 1.00 215.18 ? 20  A   B "C5'" 1 
ATOM   5657 C  "C4'" . A   B 2 20  ? 158.706 140.972 153.182 1.00 215.18 ? 20  A   B "C4'" 1 
ATOM   5658 O  "O4'" . A   B 2 20  ? 157.637 141.185 152.225 1.00 215.18 ? 20  A   B "O4'" 1 
ATOM   5659 C  "C3'" . A   B 2 20  ? 158.028 141.163 154.525 1.00 215.18 ? 20  A   B "C3'" 1 
ATOM   5660 O  "O3'" . A   B 2 20  ? 158.941 141.424 155.575 1.00 215.18 ? 20  A   B "O3'" 1 
ATOM   5661 C  "C2'" . A   B 2 20  ? 157.065 142.307 154.240 1.00 215.18 ? 20  A   B "C2'" 1 
ATOM   5662 O  "O2'" . A   B 2 20  ? 157.752 143.549 154.222 1.00 215.18 ? 20  A   B "O2'" 1 
ATOM   5663 C  "C1'" . A   B 2 20  ? 156.625 141.978 152.813 1.00 215.18 ? 20  A   B "C1'" 1 
ATOM   5664 N  N9    . A   B 2 20  ? 155.349 141.238 152.787 1.00 215.18 ? 20  A   B N9    1 
ATOM   5665 C  C8    . A   B 2 20  ? 155.139 139.905 152.529 1.00 215.18 ? 20  A   B C8    1 
ATOM   5666 N  N7    . A   B 2 20  ? 153.876 139.551 152.585 1.00 215.18 ? 20  A   B N7    1 
ATOM   5667 C  C5    . A   B 2 20  ? 153.212 140.727 152.902 1.00 215.18 ? 20  A   B C5    1 
ATOM   5668 C  C6    . A   B 2 20  ? 151.854 141.027 153.110 1.00 215.18 ? 20  A   B C6    1 
ATOM   5669 N  N6    . A   B 2 20  ? 150.879 140.121 153.021 1.00 215.18 ? 20  A   B N6    1 
ATOM   5670 N  N1    . A   B 2 20  ? 151.522 142.301 153.416 1.00 215.18 ? 20  A   B N1    1 
ATOM   5671 C  C2    . A   B 2 20  ? 152.502 143.208 153.505 1.00 215.18 ? 20  A   B C2    1 
ATOM   5672 N  N3    . A   B 2 20  ? 153.813 143.049 153.334 1.00 215.18 ? 20  A   B N3    1 
ATOM   5673 C  C4    . A   B 2 20  ? 154.107 141.772 153.030 1.00 215.18 ? 20  A   B C4    1 
ATOM   5674 P  P     . U   B 2 21  ? 158.614 140.916 157.062 1.00 187.85 ? 21  U   B P     1 
ATOM   5675 O  OP1   . U   B 2 21  ? 159.871 140.939 157.851 1.00 187.85 ? 21  U   B OP1   1 
ATOM   5676 O  OP2   . U   B 2 21  ? 157.839 139.652 156.957 1.00 187.85 ? 21  U   B OP2   1 
ATOM   5677 O  "O5'" . U   B 2 21  ? 157.647 142.044 157.635 1.00 187.85 ? 21  U   B "O5'" 1 
ATOM   5678 C  "C5'" . U   B 2 21  ? 157.990 143.414 157.509 1.00 187.85 ? 21  U   B "C5'" 1 
ATOM   5679 C  "C4'" . U   B 2 21  ? 156.789 144.308 157.690 1.00 187.85 ? 21  U   B "C4'" 1 
ATOM   5680 O  "O4'" . U   B 2 21  ? 155.867 144.148 156.581 1.00 187.85 ? 21  U   B "O4'" 1 
ATOM   5681 C  "C3'" . U   B 2 21  ? 155.934 144.032 158.913 1.00 187.85 ? 21  U   B "C3'" 1 
ATOM   5682 O  "O3'" . U   B 2 21  ? 156.489 144.556 160.105 1.00 187.85 ? 21  U   B "O3'" 1 
ATOM   5683 C  "C2'" . U   B 2 21  ? 154.603 144.659 158.525 1.00 187.85 ? 21  U   B "C2'" 1 
ATOM   5684 O  "O2'" . U   B 2 21  ? 154.652 146.070 158.672 1.00 187.85 ? 21  U   B "O2'" 1 
ATOM   5685 C  "C1'" . U   B 2 21  ? 154.540 144.331 157.033 1.00 187.85 ? 21  U   B "C1'" 1 
ATOM   5686 N  N1    . U   B 2 21  ? 153.765 143.097 156.766 1.00 187.85 ? 21  U   B N1    1 
ATOM   5687 C  C2    . U   B 2 21  ? 152.385 143.152 156.869 1.00 187.85 ? 21  U   B C2    1 
ATOM   5688 O  O2    . U   B 2 21  ? 151.778 144.165 157.172 1.00 187.85 ? 21  U   B O2    1 
ATOM   5689 N  N3    . U   B 2 21  ? 151.731 141.972 156.611 1.00 187.85 ? 21  U   B N3    1 
ATOM   5690 C  C4    . U   B 2 21  ? 152.310 140.767 156.266 1.00 187.85 ? 21  U   B C4    1 
ATOM   5691 O  O4    . U   B 2 21  ? 151.604 139.779 156.057 1.00 187.85 ? 21  U   B O4    1 
ATOM   5692 C  C5    . U   B 2 21  ? 153.736 140.794 156.177 1.00 187.85 ? 21  U   B C5    1 
ATOM   5693 C  C6    . U   B 2 21  ? 154.396 141.928 156.424 1.00 187.85 ? 21  U   B C6    1 
ATOM   5694 P  P     . C   B 2 22  ? 156.198 143.833 161.510 1.00 160.93 ? 22  C   B P     1 
ATOM   5695 O  OP1   . C   B 2 22  ? 157.098 144.429 162.529 1.00 160.93 ? 22  C   B OP1   1 
ATOM   5696 O  OP2   . C   B 2 22  ? 156.216 142.366 161.288 1.00 160.93 ? 22  C   B OP2   1 
ATOM   5697 O  "O5'" . C   B 2 22  ? 154.704 144.265 161.852 1.00 160.93 ? 22  C   B "O5'" 1 
ATOM   5698 C  "C5'" . C   B 2 22  ? 154.353 145.638 161.949 1.00 160.93 ? 22  C   B "C5'" 1 
ATOM   5699 C  "C4'" . C   B 2 22  ? 152.859 145.832 161.929 1.00 160.93 ? 22  C   B "C4'" 1 
ATOM   5700 O  "O4'" . C   B 2 22  ? 152.310 145.381 160.663 1.00 160.93 ? 22  C   B "O4'" 1 
ATOM   5701 C  "C3'" . C   B 2 22  ? 152.075 145.048 162.963 1.00 160.93 ? 22  C   B "C3'" 1 
ATOM   5702 O  "O3'" . C   B 2 22  ? 152.106 145.644 164.246 1.00 160.93 ? 22  C   B "O3'" 1 
ATOM   5703 C  "C2'" . C   B 2 22  ? 150.685 144.997 162.350 1.00 160.93 ? 22  C   B "C2'" 1 
ATOM   5704 O  "O2'" . C   B 2 22  ? 150.011 146.233 162.535 1.00 160.93 ? 22  C   B "O2'" 1 
ATOM   5705 C  "C1'" . C   B 2 22  ? 151.017 144.847 160.865 1.00 160.93 ? 22  C   B "C1'" 1 
ATOM   5706 N  N1    . C   B 2 22  ? 151.012 143.430 160.434 1.00 160.93 ? 22  C   B N1    1 
ATOM   5707 C  C2    . C   B 2 22  ? 149.791 142.752 160.313 1.00 160.93 ? 22  C   B C2    1 
ATOM   5708 O  O2    . C   B 2 22  ? 148.744 143.361 160.579 1.00 160.93 ? 22  C   B O2    1 
ATOM   5709 N  N3    . C   B 2 22  ? 149.790 141.457 159.918 1.00 160.93 ? 22  C   B N3    1 
ATOM   5710 C  C4    . C   B 2 22  ? 150.943 140.844 159.644 1.00 160.93 ? 22  C   B C4    1 
ATOM   5711 N  N4    . C   B 2 22  ? 150.906 139.568 159.255 1.00 160.93 ? 22  C   B N4    1 
ATOM   5712 C  C5    . C   B 2 22  ? 152.196 141.510 159.755 1.00 160.93 ? 22  C   B C5    1 
ATOM   5713 C  C6    . C   B 2 22  ? 152.182 142.788 160.150 1.00 160.93 ? 22  C   B C6    1 
ATOM   5714 P  P     . C   B 2 23  ? 152.097 144.721 165.557 1.00 140.00 ? 23  C   B P     1 
ATOM   5715 O  OP1   . C   B 2 23  ? 152.549 145.564 166.687 1.00 140.00 ? 23  C   B OP1   1 
ATOM   5716 O  OP2   . C   B 2 23  ? 152.827 143.468 165.245 1.00 140.00 ? 23  C   B OP2   1 
ATOM   5717 O  "O5'" . C   B 2 23  ? 150.559 144.355 165.759 1.00 140.00 ? 23  C   B "O5'" 1 
ATOM   5718 C  "C5'" . C   B 2 23  ? 149.572 145.373 165.844 1.00 140.00 ? 23  C   B "C5'" 1 
ATOM   5719 C  "C4'" . C   B 2 23  ? 148.189 144.838 165.562 1.00 140.00 ? 23  C   B "C4'" 1 
ATOM   5720 O  "O4'" . C   B 2 23  ? 148.137 144.277 164.226 1.00 140.00 ? 23  C   B "O4'" 1 
ATOM   5721 C  "C3'" . C   B 2 23  ? 147.711 143.710 166.461 1.00 140.00 ? 23  C   B "C3'" 1 
ATOM   5722 O  "O3'" . C   B 2 23  ? 147.195 144.185 167.689 1.00 140.00 ? 23  C   B "O3'" 1 
ATOM   5723 C  "C2'" . C   B 2 23  ? 146.665 143.014 165.602 1.00 140.00 ? 23  C   B "C2'" 1 
ATOM   5724 O  "O2'" . C   B 2 23  ? 145.432 143.715 165.652 1.00 140.00 ? 23  C   B "O2'" 1 
ATOM   5725 C  "C1'" . C   B 2 23  ? 147.256 143.175 164.200 1.00 140.00 ? 23  C   B "C1'" 1 
ATOM   5726 N  N1    . C   B 2 23  ? 148.008 141.979 163.756 1.00 140.00 ? 23  C   B N1    1 
ATOM   5727 C  C2    . C   B 2 23  ? 147.321 140.803 163.426 1.00 140.00 ? 23  C   B C2    1 
ATOM   5728 O  O2    . C   B 2 23  ? 146.086 140.782 163.532 1.00 140.00 ? 23  C   B O2    1 
ATOM   5729 N  N3    . C   B 2 23  ? 148.027 139.724 163.015 1.00 140.00 ? 23  C   B N3    1 
ATOM   5730 C  C4    . C   B 2 23  ? 149.355 139.794 162.917 1.00 140.00 ? 23  C   B C4    1 
ATOM   5731 N  N4    . C   B 2 23  ? 150.017 138.712 162.506 1.00 140.00 ? 23  C   B N4    1 
ATOM   5732 C  C5    . C   B 2 23  ? 150.075 140.978 163.236 1.00 140.00 ? 23  C   B C5    1 
ATOM   5733 C  C6    . C   B 2 23  ? 149.367 142.034 163.645 1.00 140.00 ? 23  C   B C6    1 
ATOM   5734 P  P     . A   B 2 24  ? 147.250 143.272 169.007 1.00 127.72 ? 24  A   B P     1 
ATOM   5735 O  OP1   . A   B 2 24  ? 146.657 144.081 170.098 1.00 127.72 ? 24  A   B OP1   1 
ATOM   5736 O  OP2   . A   B 2 24  ? 148.623 142.729 169.150 1.00 127.72 ? 24  A   B OP2   1 
ATOM   5737 O  "O5'" . A   B 2 24  ? 146.255 142.065 168.695 1.00 127.72 ? 24  A   B "O5'" 1 
ATOM   5738 C  "C5'" . A   B 2 24  ? 144.848 142.239 168.780 1.00 127.72 ? 24  A   B "C5'" 1 
ATOM   5739 C  "C4'" . A   B 2 24  ? 144.101 140.965 168.466 1.00 127.72 ? 24  A   B "C4'" 1 
ATOM   5740 O  "O4'" . A   B 2 24  ? 144.366 140.563 167.099 1.00 127.72 ? 24  A   B "O4'" 1 
ATOM   5741 C  "C3'" . A   B 2 24  ? 144.476 139.744 169.291 1.00 127.72 ? 24  A   B "C3'" 1 
ATOM   5742 O  "O3'" . A   B 2 24  ? 143.831 139.721 170.553 1.00 127.72 ? 24  A   B "O3'" 1 
ATOM   5743 C  "C2'" . A   B 2 24  ? 144.068 138.588 168.388 1.00 127.72 ? 24  A   B "C2'" 1 
ATOM   5744 O  "O2'" . A   B 2 24  ? 142.672 138.351 168.482 1.00 127.72 ? 24  A   B "O2'" 1 
ATOM   5745 C  "C1'" . A   B 2 24  ? 144.368 139.155 167.001 1.00 127.72 ? 24  A   B "C1'" 1 
ATOM   5746 N  N9    . A   B 2 24  ? 145.676 138.720 166.478 1.00 127.72 ? 24  A   B N9    1 
ATOM   5747 C  C8    . A   B 2 24  ? 146.851 139.429 166.468 1.00 127.72 ? 24  A   B C8    1 
ATOM   5748 N  N7    . A   B 2 24  ? 147.852 138.787 165.920 1.00 127.72 ? 24  A   B N7    1 
ATOM   5749 C  C5    . A   B 2 24  ? 147.298 137.574 165.537 1.00 127.72 ? 24  A   B C5    1 
ATOM   5750 C  C6    . A   B 2 24  ? 147.844 136.448 164.897 1.00 127.72 ? 24  A   B C6    1 
ATOM   5751 N  N6    . A   B 2 24  ? 149.119 136.367 164.521 1.00 127.72 ? 24  A   B N6    1 
ATOM   5752 N  N1    . A   B 2 24  ? 147.031 135.398 164.655 1.00 127.72 ? 24  A   B N1    1 
ATOM   5753 C  C2    . A   B 2 24  ? 145.750 135.486 165.035 1.00 127.72 ? 24  A   B C2    1 
ATOM   5754 N  N3    . A   B 2 24  ? 145.121 136.491 165.644 1.00 127.72 ? 24  A   B N3    1 
ATOM   5755 C  C4    . A   B 2 24  ? 145.959 137.518 165.870 1.00 127.72 ? 24  A   B C4    1 
ATOM   5756 P  P     . U   B 2 25  ? 144.106 138.518 171.582 1.00 124.83 ? 25  U   B P     1 
ATOM   5757 O  OP1   . U   B 2 25  ? 143.664 138.955 172.929 1.00 124.83 ? 25  U   B OP1   1 
ATOM   5758 O  OP2   . U   B 2 25  ? 145.504 138.065 171.380 1.00 124.83 ? 25  U   B OP2   1 
ATOM   5759 O  "O5'" . U   B 2 25  ? 143.133 137.352 171.096 1.00 124.83 ? 25  U   B "O5'" 1 
ATOM   5760 C  "C5'" . U   B 2 25  ? 143.132 136.090 171.751 1.00 124.83 ? 25  U   B "C5'" 1 
ATOM   5761 C  "C4'" . U   B 2 25  ? 142.849 134.957 170.795 1.00 124.83 ? 25  U   B "C4'" 1 
ATOM   5762 O  "O4'" . U   B 2 25  ? 143.380 135.270 169.485 1.00 124.83 ? 25  U   B "O4'" 1 
ATOM   5763 C  "C3'" . U   B 2 25  ? 143.487 133.624 171.159 1.00 124.83 ? 25  U   B "C3'" 1 
ATOM   5764 O  "O3'" . U   B 2 25  ? 142.699 132.894 172.082 1.00 124.83 ? 25  U   B "O3'" 1 
ATOM   5765 C  "C2'" . U   B 2 25  ? 143.635 132.925 169.812 1.00 124.83 ? 25  U   B "C2'" 1 
ATOM   5766 O  "O2'" . U   B 2 25  ? 142.420 132.292 169.445 1.00 124.83 ? 25  U   B "O2'" 1 
ATOM   5767 C  "C1'" . U   B 2 25  ? 143.869 134.102 168.863 1.00 124.83 ? 25  U   B "C1'" 1 
ATOM   5768 N  N1    . U   B 2 25  ? 145.290 134.327 168.504 1.00 124.83 ? 25  U   B N1    1 
ATOM   5769 C  C2    . U   B 2 25  ? 145.990 133.423 167.715 1.00 124.83 ? 25  U   B C2    1 
ATOM   5770 O  O2    . U   B 2 25  ? 145.514 132.380 167.305 1.00 124.83 ? 25  U   B O2    1 
ATOM   5771 N  N3    . U   B 2 25  ? 147.292 133.786 167.438 1.00 124.83 ? 25  U   B N3    1 
ATOM   5772 C  C4    . U   B 2 25  ? 147.936 134.938 167.849 1.00 124.83 ? 25  U   B C4    1 
ATOM   5773 O  O4    . U   B 2 25  ? 149.106 135.153 167.535 1.00 124.83 ? 25  U   B O4    1 
ATOM   5774 C  C5    . U   B 2 25  ? 147.141 135.821 168.638 1.00 124.83 ? 25  U   B C5    1 
ATOM   5775 C  C6    . U   B 2 25  ? 145.881 135.495 168.922 1.00 124.83 ? 25  U   B C6    1 
ATOM   5776 P  P     . C   B 2 26  ? 143.387 131.998 173.221 1.00 139.25 ? 26  C   B P     1 
ATOM   5777 O  OP1   . C   B 2 26  ? 142.301 131.379 174.021 1.00 139.25 ? 26  C   B OP1   1 
ATOM   5778 O  OP2   . C   B 2 26  ? 144.424 132.813 173.901 1.00 139.25 ? 26  C   B OP2   1 
ATOM   5779 O  "O5'" . C   B 2 26  ? 144.104 130.832 172.410 1.00 139.25 ? 26  C   B "O5'" 1 
ATOM   5780 C  "C5'" . C   B 2 26  ? 143.343 129.814 171.779 1.00 139.25 ? 26  C   B "C5'" 1 
ATOM   5781 C  "C4'" . C   B 2 26  ? 144.223 128.862 171.010 1.00 139.25 ? 26  C   B "C4'" 1 
ATOM   5782 O  "O4'" . C   B 2 26  ? 144.902 129.569 169.944 1.00 139.25 ? 26  C   B "O4'" 1 
ATOM   5783 C  "C3'" . C   B 2 26  ? 145.350 128.208 171.792 1.00 139.25 ? 26  C   B "C3'" 1 
ATOM   5784 O  "O3'" . C   B 2 26  ? 144.914 127.101 172.559 1.00 139.25 ? 26  C   B "O3'" 1 
ATOM   5785 C  "C2'" . C   B 2 26  ? 146.341 127.832 170.698 1.00 139.25 ? 26  C   B "C2'" 1 
ATOM   5786 O  "O2'" . C   B 2 26  ? 145.940 126.632 170.053 1.00 139.25 ? 26  C   B "O2'" 1 
ATOM   5787 C  "C1'" . C   B 2 26  ? 146.168 128.990 169.713 1.00 139.25 ? 26  C   B "C1'" 1 
ATOM   5788 N  N1    . C   B 2 26  ? 147.214 130.027 169.863 1.00 139.25 ? 26  C   B N1    1 
ATOM   5789 C  C2    . C   B 2 26  ? 148.390 129.883 169.127 1.00 139.25 ? 26  C   B C2    1 
ATOM   5790 O  O2    . C   B 2 26  ? 148.513 128.896 168.389 1.00 139.25 ? 26  C   B O2    1 
ATOM   5791 N  N3    . C   B 2 26  ? 149.367 130.810 169.230 1.00 139.25 ? 26  C   B N3    1 
ATOM   5792 C  C4    . C   B 2 26  ? 149.194 131.857 170.036 1.00 139.25 ? 26  C   B C4    1 
ATOM   5793 N  N4    . C   B 2 26  ? 150.180 132.752 170.113 1.00 139.25 ? 26  C   B N4    1 
ATOM   5794 C  C5    . C   B 2 26  ? 148.005 132.035 170.800 1.00 139.25 ? 26  C   B C5    1 
ATOM   5795 C  C6    . C   B 2 26  ? 147.048 131.106 170.686 1.00 139.25 ? 26  C   B C6    1 
ATOM   5796 P  P     . G   B 2 27  ? 144.838 127.210 174.160 1.00 188.37 ? 27  G   B P     1 
ATOM   5797 O  OP1   . G   B 2 27  ? 144.573 125.855 174.705 1.00 188.37 ? 27  G   B OP1   1 
ATOM   5798 O  OP2   . G   B 2 27  ? 143.921 128.326 174.489 1.00 188.37 ? 27  G   B OP2   1 
ATOM   5799 O  "O5'" . G   B 2 27  ? 146.312 127.637 174.585 1.00 188.37 ? 27  G   B "O5'" 1 
ATOM   5800 C  "C5'" . G   B 2 27  ? 147.253 126.671 175.027 1.00 188.37 ? 27  G   B "C5'" 1 
ATOM   5801 C  "C4'" . G   B 2 27  ? 148.119 126.185 173.894 1.00 188.37 ? 27  G   B "C4'" 1 
ATOM   5802 O  "O4'" . G   B 2 27  ? 148.423 127.287 173.001 1.00 188.37 ? 27  G   B "O4'" 1 
ATOM   5803 C  "C3'" . G   B 2 27  ? 149.483 125.636 174.283 1.00 188.37 ? 27  G   B "C3'" 1 
ATOM   5804 O  "O3'" . G   B 2 27  ? 149.432 124.293 174.732 1.00 188.37 ? 27  G   B "O3'" 1 
ATOM   5805 C  "C2'" . G   B 2 27  ? 150.294 125.825 173.007 1.00 188.37 ? 27  G   B "C2'" 1 
ATOM   5806 O  "O2'" . G   B 2 27  ? 149.996 124.805 172.067 1.00 188.37 ? 27  G   B "O2'" 1 
ATOM   5807 C  "C1'" . G   B 2 27  ? 149.728 127.145 172.483 1.00 188.37 ? 27  G   B "C1'" 1 
ATOM   5808 N  N9    . G   B 2 27  ? 150.526 128.303 172.925 1.00 188.37 ? 27  G   B N9    1 
ATOM   5809 C  C8    . G   B 2 27  ? 150.219 129.148 173.964 1.00 188.37 ? 27  G   B C8    1 
ATOM   5810 N  N7    . G   B 2 27  ? 151.106 130.086 174.139 1.00 188.37 ? 27  G   B N7    1 
ATOM   5811 C  C5    . G   B 2 27  ? 152.050 129.848 173.151 1.00 188.37 ? 27  G   B C5    1 
ATOM   5812 C  C6    . G   B 2 27  ? 153.244 130.545 172.851 1.00 188.37 ? 27  G   B C6    1 
ATOM   5813 O  O6    . G   B 2 27  ? 153.703 131.544 173.412 1.00 188.37 ? 27  G   B O6    1 
ATOM   5814 N  N1    . G   B 2 27  ? 153.916 129.978 171.774 1.00 188.37 ? 27  G   B N1    1 
ATOM   5815 C  C2    . G   B 2 27  ? 153.491 128.875 171.077 1.00 188.37 ? 27  G   B C2    1 
ATOM   5816 N  N2    . G   B 2 27  ? 154.287 128.483 170.072 1.00 188.37 ? 27  G   B N2    1 
ATOM   5817 N  N3    . G   B 2 27  ? 152.379 128.210 171.348 1.00 188.37 ? 27  G   B N3    1 
ATOM   5818 C  C4    . G   B 2 27  ? 151.711 128.749 172.391 1.00 188.37 ? 27  G   B C4    1 
ATOM   5819 O  "O5'" . C   C 3 1   ? 163.254 130.433 170.146 1.00 215.55 ? 1   C   C "O5'" 1 
ATOM   5820 C  "C5'" . C   C 3 1   ? 162.629 131.247 169.158 1.00 215.55 ? 1   C   C "C5'" 1 
ATOM   5821 C  "C4'" . C   C 3 1   ? 161.550 130.497 168.419 1.00 215.55 ? 1   C   C "C4'" 1 
ATOM   5822 O  "O4'" . C   C 3 1   ? 160.512 130.099 169.359 1.00 215.55 ? 1   C   C "O4'" 1 
ATOM   5823 C  "C3'" . C   C 3 1   ? 160.846 131.285 167.319 1.00 215.55 ? 1   C   C "C3'" 1 
ATOM   5824 O  "O3'" . C   C 3 1   ? 160.462 130.384 166.283 1.00 215.55 ? 1   C   C "O3'" 1 
ATOM   5825 C  "C2'" . C   C 3 1   ? 159.600 131.801 168.030 1.00 215.55 ? 1   C   C "C2'" 1 
ATOM   5826 O  "O2'" . C   C 3 1   ? 158.525 132.129 167.177 1.00 215.55 ? 1   C   C "O2'" 1 
ATOM   5827 C  "C1'" . C   C 3 1   ? 159.266 130.629 168.946 1.00 215.55 ? 1   C   C "C1'" 1 
ATOM   5828 N  N1    . C   C 3 1   ? 158.517 131.021 170.147 1.00 215.55 ? 1   C   C N1    1 
ATOM   5829 C  C2    . C   C 3 1   ? 157.373 130.313 170.536 1.00 215.55 ? 1   C   C C2    1 
ATOM   5830 O  O2    . C   C 3 1   ? 156.981 129.343 169.870 1.00 215.55 ? 1   C   C O2    1 
ATOM   5831 N  N3    . C   C 3 1   ? 156.708 130.706 171.647 1.00 215.55 ? 1   C   C N3    1 
ATOM   5832 C  C4    . C   C 3 1   ? 157.146 131.751 172.350 1.00 215.55 ? 1   C   C C4    1 
ATOM   5833 N  N4    . C   C 3 1   ? 156.463 132.105 173.436 1.00 215.55 ? 1   C   C N4    1 
ATOM   5834 C  C5    . C   C 3 1   ? 158.301 132.490 171.973 1.00 215.55 ? 1   C   C C5    1 
ATOM   5835 C  C6    . C   C 3 1   ? 158.946 132.093 170.873 1.00 215.55 ? 1   C   C C6    1 
ATOM   5836 P  P     . G   C 3 2   ? 160.130 130.921 164.806 1.00 164.55 ? 2   G   C P     1 
ATOM   5837 O  OP1   . G   C 3 2   ? 161.298 130.619 163.942 1.00 164.55 ? 2   G   C OP1   1 
ATOM   5838 O  OP2   . G   C 3 2   ? 159.632 132.317 164.896 1.00 164.55 ? 2   G   C OP2   1 
ATOM   5839 O  "O5'" . G   C 3 2   ? 158.924 129.988 164.348 1.00 164.55 ? 2   G   C "O5'" 1 
ATOM   5840 C  "C5'" . G   C 3 2   ? 159.103 128.585 164.250 1.00 164.55 ? 2   G   C "C5'" 1 
ATOM   5841 C  "C4'" . G   C 3 2   ? 157.830 127.829 164.537 1.00 164.55 ? 2   G   C "C4'" 1 
ATOM   5842 O  "O4'" . G   C 3 2   ? 157.438 127.995 165.924 1.00 164.55 ? 2   G   C "O4'" 1 
ATOM   5843 C  "C3'" . G   C 3 2   ? 156.600 128.261 163.764 1.00 164.55 ? 2   G   C "C3'" 1 
ATOM   5844 O  "O3'" . G   C 3 2   ? 156.585 127.780 162.433 1.00 164.55 ? 2   G   C "O3'" 1 
ATOM   5845 C  "C2'" . G   C 3 2   ? 155.466 127.716 164.623 1.00 164.55 ? 2   G   C "C2'" 1 
ATOM   5846 O  "O2'" . G   C 3 2   ? 155.293 126.325 164.398 1.00 164.55 ? 2   G   C "O2'" 1 
ATOM   5847 C  "C1'" . G   C 3 2   ? 156.031 127.905 166.031 1.00 164.55 ? 2   G   C "C1'" 1 
ATOM   5848 N  N9    . G   C 3 2   ? 155.505 129.118 166.686 1.00 164.55 ? 2   G   C N9    1 
ATOM   5849 C  C8    . G   C 3 2   ? 156.162 130.291 166.955 1.00 164.55 ? 2   G   C C8    1 
ATOM   5850 N  N7    . G   C 3 2   ? 155.407 131.174 167.551 1.00 164.55 ? 2   G   C N7    1 
ATOM   5851 C  C5    . G   C 3 2   ? 154.177 130.546 167.689 1.00 164.55 ? 2   G   C C5    1 
ATOM   5852 C  C6    . G   C 3 2   ? 152.960 131.006 168.259 1.00 164.55 ? 2   G   C C6    1 
ATOM   5853 O  O6    . G   C 3 2   ? 152.724 132.102 168.782 1.00 164.55 ? 2   G   C O6    1 
ATOM   5854 N  N1    . G   C 3 2   ? 151.959 130.042 168.189 1.00 164.55 ? 2   G   C N1    1 
ATOM   5855 C  C2    . G   C 3 2   ? 152.112 128.795 167.636 1.00 164.55 ? 2   G   C C2    1 
ATOM   5856 N  N2    . G   C 3 2   ? 151.035 127.997 167.654 1.00 164.55 ? 2   G   C N2    1 
ATOM   5857 N  N3    . G   C 3 2   ? 153.239 128.355 167.101 1.00 164.55 ? 2   G   C N3    1 
ATOM   5858 C  C4    . G   C 3 2   ? 154.224 129.275 167.160 1.00 164.55 ? 2   G   C C4    1 
ATOM   5859 P  P     . A   C 3 3   ? 155.763 128.571 161.304 1.00 148.35 ? 3   A   C P     1 
ATOM   5860 O  OP1   . A   C 3 3   ? 156.130 128.005 159.982 1.00 148.35 ? 3   A   C OP1   1 
ATOM   5861 O  OP2   . A   C 3 3   ? 155.939 130.024 161.552 1.00 148.35 ? 3   A   C OP2   1 
ATOM   5862 O  "O5'" . A   C 3 3   ? 154.244 128.195 161.603 1.00 148.35 ? 3   A   C "O5'" 1 
ATOM   5863 C  "C5'" . A   C 3 3   ? 153.824 126.839 161.618 1.00 148.35 ? 3   A   C "C5'" 1 
ATOM   5864 C  "C4'" . A   C 3 3   ? 152.452 126.684 162.225 1.00 148.35 ? 3   A   C "C4'" 1 
ATOM   5865 O  "O4'" . A   C 3 3   ? 152.467 127.071 163.623 1.00 148.35 ? 3   A   C "O4'" 1 
ATOM   5866 C  "C3'" . A   C 3 3   ? 151.356 127.540 161.625 1.00 148.35 ? 3   A   C "C3'" 1 
ATOM   5867 O  "O3'" . A   C 3 3   ? 150.860 127.020 160.405 1.00 148.35 ? 3   A   C "O3'" 1 
ATOM   5868 C  "C2'" . A   C 3 3   ? 150.320 127.575 162.741 1.00 148.35 ? 3   A   C "C2'" 1 
ATOM   5869 O  "O2'" . A   C 3 3   ? 149.575 126.368 162.768 1.00 148.35 ? 3   A   C "O2'" 1 
ATOM   5870 C  "C1'" . A   C 3 3   ? 151.214 127.617 163.980 1.00 148.35 ? 3   A   C "C1'" 1 
ATOM   5871 N  N9    . A   C 3 3   ? 151.412 128.994 164.472 1.00 148.35 ? 3   A   C N9    1 
ATOM   5872 C  C8    . A   C 3 3   ? 152.573 129.724 164.446 1.00 148.35 ? 3   A   C C8    1 
ATOM   5873 N  N7    . A   C 3 3   ? 152.454 130.922 164.959 1.00 148.35 ? 3   A   C N7    1 
ATOM   5874 C  C5    . A   C 3 3   ? 151.122 130.990 165.347 1.00 148.35 ? 3   A   C C5    1 
ATOM   5875 C  C6    . A   C 3 3   ? 150.370 132.008 165.957 1.00 148.35 ? 3   A   C C6    1 
ATOM   5876 N  N6    . A   C 3 3   ? 150.887 133.191 166.286 1.00 148.35 ? 3   A   C N6    1 
ATOM   5877 N  N1    . A   C 3 3   ? 149.064 131.777 166.218 1.00 148.35 ? 3   A   C N1    1 
ATOM   5878 C  C2    . A   C 3 3   ? 148.558 130.583 165.877 1.00 148.35 ? 3   A   C C2    1 
ATOM   5879 N  N3    . A   C 3 3   ? 149.168 129.543 165.303 1.00 148.35 ? 3   A   C N3    1 
ATOM   5880 C  C4    . A   C 3 3   ? 150.466 129.809 165.058 1.00 148.35 ? 3   A   C C4    1 
ATOM   5881 P  P     . U   C 3 4   ? 150.303 128.017 159.278 1.00 147.83 ? 4   U   C P     1 
ATOM   5882 O  OP1   . U   C 3 4   ? 150.138 127.252 158.017 1.00 147.83 ? 4   U   C OP1   1 
ATOM   5883 O  OP2   . U   C 3 4   ? 151.156 129.232 159.289 1.00 147.83 ? 4   U   C OP2   1 
ATOM   5884 O  "O5'" . U   C 3 4   ? 148.859 128.422 159.809 1.00 147.83 ? 4   U   C "O5'" 1 
ATOM   5885 C  "C5'" . U   C 3 4   ? 147.909 127.427 160.159 1.00 147.83 ? 4   U   C "C5'" 1 
ATOM   5886 C  "C4'" . U   C 3 4   ? 146.744 128.015 160.915 1.00 147.83 ? 4   U   C "C4'" 1 
ATOM   5887 O  "O4'" . U   C 3 4   ? 147.182 128.494 162.214 1.00 147.83 ? 4   U   C "O4'" 1 
ATOM   5888 C  "C3'" . U   C 3 4   ? 146.091 129.227 160.279 1.00 147.83 ? 4   U   C "C3'" 1 
ATOM   5889 O  "O3'" . U   C 3 4   ? 145.193 128.886 159.239 1.00 147.83 ? 4   U   C "O3'" 1 
ATOM   5890 C  "C2'" . U   C 3 4   ? 145.422 129.902 161.467 1.00 147.83 ? 4   U   C "C2'" 1 
ATOM   5891 O  "O2'" . U   C 3 4   ? 144.219 129.231 161.810 1.00 147.83 ? 4   U   C "O2'" 1 
ATOM   5892 C  "C1'" . U   C 3 4   ? 146.446 129.646 162.573 1.00 147.83 ? 4   U   C "C1'" 1 
ATOM   5893 N  N1    . U   C 3 4   ? 147.388 130.777 162.739 1.00 147.83 ? 4   U   C N1    1 
ATOM   5894 C  C2    . U   C 3 4   ? 146.931 131.968 163.280 1.00 147.83 ? 4   U   C C2    1 
ATOM   5895 O  O2    . U   C 3 4   ? 145.774 132.154 163.617 1.00 147.83 ? 4   U   C O2    1 
ATOM   5896 N  N3    . U   C 3 4   ? 147.878 132.959 163.395 1.00 147.83 ? 4   U   C N3    1 
ATOM   5897 C  C4    . U   C 3 4   ? 149.211 132.873 163.045 1.00 147.83 ? 4   U   C C4    1 
ATOM   5898 O  O4    . U   C 3 4   ? 149.960 133.837 163.206 1.00 147.83 ? 4   U   C O4    1 
ATOM   5899 C  C5    . U   C 3 4   ? 149.605 131.612 162.503 1.00 147.83 ? 4   U   C C5    1 
ATOM   5900 C  C6    . U   C 3 4   ? 148.704 130.635 162.375 1.00 147.83 ? 4   U   C C6    1 
ATOM   5901 P  P     . G   C 3 5   ? 144.979 129.890 158.005 1.00 159.73 ? 5   G   C P     1 
ATOM   5902 O  OP1   . G   C 3 5   ? 144.151 129.198 156.986 1.00 159.73 ? 5   G   C OP1   1 
ATOM   5903 O  OP2   . G   C 3 5   ? 146.305 130.435 157.624 1.00 159.73 ? 5   G   C OP2   1 
ATOM   5904 O  "O5'" . G   C 3 5   ? 144.116 131.077 158.625 1.00 159.73 ? 5   G   C "O5'" 1 
ATOM   5905 C  "C5'" . G   C 3 5   ? 142.837 130.826 159.186 1.00 159.73 ? 5   G   C "C5'" 1 
ATOM   5906 C  "C4'" . G   C 3 5   ? 142.295 132.038 159.902 1.00 159.73 ? 5   G   C "C4'" 1 
ATOM   5907 O  "O4'" . G   C 3 5   ? 143.074 132.303 161.097 1.00 159.73 ? 5   G   C "O4'" 1 
ATOM   5908 C  "C3'" . G   C 3 5   ? 142.351 133.344 159.132 1.00 159.73 ? 5   G   C "C3'" 1 
ATOM   5909 O  "O3'" . G   C 3 5   ? 141.302 133.475 158.191 1.00 159.73 ? 5   G   C "O3'" 1 
ATOM   5910 C  "C2'" . G   C 3 5   ? 142.308 134.381 160.244 1.00 159.73 ? 5   G   C "C2'" 1 
ATOM   5911 O  "O2'" . G   C 3 5   ? 140.986 134.533 160.737 1.00 159.73 ? 5   G   C "O2'" 1 
ATOM   5912 C  "C1'" . G   C 3 5   ? 143.148 133.697 161.321 1.00 159.73 ? 5   G   C "C1'" 1 
ATOM   5913 N  N9    . G   C 3 5   ? 144.561 134.109 161.255 1.00 159.73 ? 5   G   C N9    1 
ATOM   5914 C  C8    . G   C 3 5   ? 145.625 133.347 160.844 1.00 159.73 ? 5   G   C C8    1 
ATOM   5915 N  N7    . G   C 3 5   ? 146.763 133.984 160.895 1.00 159.73 ? 5   G   C N7    1 
ATOM   5916 C  C5    . G   C 3 5   ? 146.427 135.248 161.361 1.00 159.73 ? 5   G   C C5    1 
ATOM   5917 C  C6    . G   C 3 5   ? 147.243 136.379 161.610 1.00 159.73 ? 5   G   C C6    1 
ATOM   5918 O  O6    . G   C 3 5   ? 148.466 136.479 161.473 1.00 159.73 ? 5   G   C O6    1 
ATOM   5919 N  N1    . G   C 3 5   ? 146.499 137.460 162.075 1.00 159.73 ? 5   G   C N1    1 
ATOM   5920 C  C2    . G   C 3 5   ? 145.140 137.450 162.267 1.00 159.73 ? 5   G   C C2    1 
ATOM   5921 N  N2    . G   C 3 5   ? 144.590 138.586 162.717 1.00 159.73 ? 5   G   C N2    1 
ATOM   5922 N  N3    . G   C 3 5   ? 144.367 136.402 162.034 1.00 159.73 ? 5   G   C N3    1 
ATOM   5923 C  C4    . G   C 3 5   ? 145.072 135.342 161.587 1.00 159.73 ? 5   G   C C4    1 
ATOM   5924 P  P     . G   C 3 6   ? 141.537 134.311 156.842 1.00 178.01 ? 6   G   C P     1 
ATOM   5925 O  OP1   . G   C 3 6   ? 140.386 134.056 155.943 1.00 178.01 ? 6   G   C OP1   1 
ATOM   5926 O  OP2   . G   C 3 6   ? 142.917 134.041 156.367 1.00 178.01 ? 6   G   C OP2   1 
ATOM   5927 O  "O5'" . G   C 3 6   ? 141.461 135.829 157.316 1.00 178.01 ? 6   G   C "O5'" 1 
ATOM   5928 C  "C5'" . G   C 3 6   ? 140.286 136.343 157.926 1.00 178.01 ? 6   G   C "C5'" 1 
ATOM   5929 C  "C4'" . G   C 3 6   ? 140.535 137.691 158.551 1.00 178.01 ? 6   G   C "C4'" 1 
ATOM   5930 O  "O4'" . G   C 3 6   ? 141.524 137.568 159.605 1.00 178.01 ? 6   G   C "O4'" 1 
ATOM   5931 C  "C3'" . G   C 3 6   ? 141.111 138.752 157.627 1.00 178.01 ? 6   G   C "C3'" 1 
ATOM   5932 O  "O3'" . G   C 3 6   ? 140.122 139.378 156.829 1.00 178.01 ? 6   G   C "O3'" 1 
ATOM   5933 C  "C2'" . G   C 3 6   ? 141.802 139.700 158.597 1.00 178.01 ? 6   G   C "C2'" 1 
ATOM   5934 O  "O2'" . G   C 3 6   ? 140.856 140.553 159.221 1.00 178.01 ? 6   G   C "O2'" 1 
ATOM   5935 C  "C1'" . G   C 3 6   ? 142.334 138.723 159.645 1.00 178.01 ? 6   G   C "C1'" 1 
ATOM   5936 N  N9    . G   C 3 6   ? 143.731 138.327 159.383 1.00 178.01 ? 6   G   C N9    1 
ATOM   5937 C  C8    . G   C 3 6   ? 144.185 137.088 159.001 1.00 178.01 ? 6   G   C C8    1 
ATOM   5938 N  N7    . G   C 3 6   ? 145.479 137.037 158.853 1.00 178.01 ? 6   G   C N7    1 
ATOM   5939 C  C5    . G   C 3 6   ? 145.910 138.321 159.156 1.00 178.01 ? 6   G   C C5    1 
ATOM   5940 C  C6    . G   C 3 6   ? 147.217 138.874 159.165 1.00 178.01 ? 6   G   C C6    1 
ATOM   5941 O  O6    . G   C 3 6   ? 148.285 138.310 158.904 1.00 178.01 ? 6   G   C O6    1 
ATOM   5942 N  N1    . G   C 3 6   ? 147.206 140.217 159.534 1.00 178.01 ? 6   G   C N1    1 
ATOM   5943 C  C2    . G   C 3 6   ? 146.077 140.933 159.847 1.00 178.01 ? 6   G   C C2    1 
ATOM   5944 N  N2    . G   C 3 6   ? 146.254 142.220 160.174 1.00 178.01 ? 6   G   C N2    1 
ATOM   5945 N  N3    . G   C 3 6   ? 144.854 140.429 159.839 1.00 178.01 ? 6   G   C N3    1 
ATOM   5946 C  C4    . G   C 3 6   ? 144.844 139.127 159.488 1.00 178.01 ? 6   G   C C4    1 
ATOM   5947 P  P     . A   C 3 7   ? 140.494 139.924 155.365 1.00 199.53 ? 7   A   C P     1 
ATOM   5948 O  OP1   . A   C 3 7   ? 139.229 140.268 154.670 1.00 199.53 ? 7   A   C OP1   1 
ATOM   5949 O  OP2   . A   C 3 7   ? 141.436 138.963 154.739 1.00 199.53 ? 7   A   C OP2   1 
ATOM   5950 O  "O5'" . A   C 3 7   ? 141.286 141.278 155.649 1.00 199.53 ? 7   A   C "O5'" 1 
ATOM   5951 C  "C5'" . A   C 3 7   ? 140.674 142.343 156.360 1.00 199.53 ? 7   A   C "C5'" 1 
ATOM   5952 C  "C4'" . A   C 3 7   ? 141.675 143.406 156.734 1.00 199.53 ? 7   A   C "C4'" 1 
ATOM   5953 O  "O4'" . A   C 3 7   ? 142.649 142.861 157.660 1.00 199.53 ? 7   A   C "O4'" 1 
ATOM   5954 C  "C3'" . A   C 3 7   ? 142.515 143.956 155.592 1.00 199.53 ? 7   A   C "C3'" 1 
ATOM   5955 O  "O3'" . A   C 3 7   ? 141.837 144.954 154.850 1.00 199.53 ? 7   A   C "O3'" 1 
ATOM   5956 C  "C2'" . A   C 3 7   ? 143.760 144.468 156.305 1.00 199.53 ? 7   A   C "C2'" 1 
ATOM   5957 O  "O2'" . A   C 3 7   ? 143.511 145.736 156.894 1.00 199.53 ? 7   A   C "O2'" 1 
ATOM   5958 C  "C1'" . A   C 3 7   ? 143.916 143.440 157.425 1.00 199.53 ? 7   A   C "C1'" 1 
ATOM   5959 N  N9    . A   C 3 7   ? 144.871 142.363 157.089 1.00 199.53 ? 7   A   C N9    1 
ATOM   5960 C  C8    . A   C 3 7   ? 144.575 141.042 156.858 1.00 199.53 ? 7   A   C C8    1 
ATOM   5961 N  N7    . A   C 3 7   ? 145.620 140.299 156.598 1.00 199.53 ? 7   A   C N7    1 
ATOM   5962 C  C5    . A   C 3 7   ? 146.681 141.187 156.664 1.00 199.53 ? 7   A   C C5    1 
ATOM   5963 C  C6    . A   C 3 7   ? 148.064 141.012 156.485 1.00 199.53 ? 7   A   C C6    1 
ATOM   5964 N  N6    . A   C 3 7   ? 148.624 139.839 156.184 1.00 199.53 ? 7   A   C N6    1 
ATOM   5965 N  N1    . A   C 3 7   ? 148.862 142.094 156.617 1.00 199.53 ? 7   A   C N1    1 
ATOM   5966 C  C2    . A   C 3 7   ? 148.294 143.270 156.917 1.00 199.53 ? 7   A   C C2    1 
ATOM   5967 N  N3    . A   C 3 7   ? 147.006 143.559 157.113 1.00 199.53 ? 7   A   C N3    1 
ATOM   5968 C  C4    . A   C 3 7   ? 146.240 142.461 156.975 1.00 199.53 ? 7   A   C C4    1 
ATOM   5969 P  P     . U   C 3 8   ? 142.131 145.138 153.281 1.00 223.25 ? 8   U   C P     1 
ATOM   5970 O  OP1   . U   C 3 8   ? 141.095 146.044 152.725 1.00 223.25 ? 8   U   C OP1   1 
ATOM   5971 O  OP2   . U   C 3 8   ? 142.319 143.790 152.688 1.00 223.25 ? 8   U   C OP2   1 
ATOM   5972 O  "O5'" . U   C 3 8   ? 143.527 145.901 153.239 1.00 223.25 ? 8   U   C "O5'" 1 
ATOM   5973 C  "C5'" . U   C 3 8   ? 143.680 147.177 153.843 1.00 223.25 ? 8   U   C "C5'" 1 
ATOM   5974 C  "C4'" . U   C 3 8   ? 145.128 147.597 153.887 1.00 223.25 ? 8   U   C "C4'" 1 
ATOM   5975 O  "O4'" . U   C 3 8   ? 145.872 146.712 154.762 1.00 223.25 ? 8   U   C "O4'" 1 
ATOM   5976 C  "C3'" . U   C 3 8   ? 145.879 147.529 152.568 1.00 223.25 ? 8   U   C "C3'" 1 
ATOM   5977 O  "O3'" . U   C 3 8   ? 145.640 148.657 151.743 1.00 223.25 ? 8   U   C "O3'" 1 
ATOM   5978 C  "C2'" . U   C 3 8   ? 147.329 147.399 153.015 1.00 223.25 ? 8   U   C "C2'" 1 
ATOM   5979 O  "O2'" . U   C 3 8   ? 147.852 148.665 153.390 1.00 223.25 ? 8   U   C "O2'" 1 
ATOM   5980 C  "C1'" . U   C 3 8   ? 147.187 146.544 154.274 1.00 223.25 ? 8   U   C "C1'" 1 
ATOM   5981 N  N1    . U   C 3 8   ? 147.425 145.101 154.026 1.00 223.25 ? 8   U   C N1    1 
ATOM   5982 C  C2    . U   C 3 8   ? 148.722 144.658 153.827 1.00 223.25 ? 8   U   C C2    1 
ATOM   5983 O  O2    . U   C 3 8   ? 149.687 145.404 153.817 1.00 223.25 ? 8   U   C O2    1 
ATOM   5984 N  N3    . U   C 3 8   ? 148.853 143.306 153.612 1.00 223.25 ? 8   U   C N3    1 
ATOM   5985 C  C4    . U   C 3 8   ? 147.841 142.368 153.593 1.00 223.25 ? 8   U   C C4    1 
ATOM   5986 O  O4    . U   C 3 8   ? 148.100 141.179 153.394 1.00 223.25 ? 8   U   C O4    1 
ATOM   5987 C  C5    . U   C 3 8   ? 146.535 142.902 153.817 1.00 223.25 ? 8   U   C C5    1 
ATOM   5988 C  C6    . U   C 3 8   ? 146.379 144.211 154.025 1.00 223.25 ? 8   U   C C6    1 
ATOM   5989 P  P     . A   C 3 9   ? 145.769 148.534 150.146 1.00 252.29 ? 9   A   C P     1 
ATOM   5990 O  OP1   . A   C 3 9   ? 145.289 149.807 149.551 1.00 252.29 ? 9   A   C OP1   1 
ATOM   5991 O  OP2   . A   C 3 9   ? 145.145 147.251 149.733 1.00 252.29 ? 9   A   C OP2   1 
ATOM   5992 O  "O5'" . A   C 3 9   ? 147.338 148.431 149.890 1.00 252.29 ? 9   A   C "O5'" 1 
ATOM   5993 C  "C5'" . A   C 3 9   ? 148.201 149.511 150.217 1.00 252.29 ? 9   A   C "C5'" 1 
ATOM   5994 C  "C4'" . A   C 3 9   ? 149.652 149.114 150.116 1.00 252.29 ? 9   A   C "C4'" 1 
ATOM   5995 O  "O4'" . A   C 3 9   ? 149.971 148.126 151.128 1.00 252.29 ? 9   A   C "O4'" 1 
ATOM   5996 C  "C3'" . A   C 3 9   ? 150.076 148.455 148.814 1.00 252.29 ? 9   A   C "C3'" 1 
ATOM   5997 O  "O3'" . A   C 3 9   ? 150.305 149.390 147.775 1.00 252.29 ? 9   A   C "O3'" 1 
ATOM   5998 C  "C2'" . A   C 3 9   ? 151.321 147.680 149.224 1.00 252.29 ? 9   A   C "C2'" 1 
ATOM   5999 O  "O2'" . A   C 3 9   ? 152.445 148.544 149.309 1.00 252.29 ? 9   A   C "O2'" 1 
ATOM   6000 C  "C1'" . A   C 3 9   ? 150.950 147.232 150.638 1.00 252.29 ? 9   A   C "C1'" 1 
ATOM   6001 N  N9    . A   C 3 9   ? 150.400 145.863 150.664 1.00 252.29 ? 9   A   C N9    1 
ATOM   6002 C  C8    . A   C 3 9   ? 149.097 145.491 150.870 1.00 252.29 ? 9   A   C C8    1 
ATOM   6003 N  N7    . A   C 3 9   ? 148.903 144.196 150.849 1.00 252.29 ? 9   A   C N7    1 
ATOM   6004 C  C5    . A   C 3 9   ? 150.166 143.680 150.606 1.00 252.29 ? 9   A   C C5    1 
ATOM   6005 C  C6    . A   C 3 9   ? 150.631 142.363 150.462 1.00 252.29 ? 9   A   C C6    1 
ATOM   6006 N  N6    . A   C 3 9   ? 149.843 141.290 150.549 1.00 252.29 ? 9   A   C N6    1 
ATOM   6007 N  N1    . A   C 3 9   ? 151.947 142.182 150.221 1.00 252.29 ? 9   A   C N1    1 
ATOM   6008 C  C2    . A   C 3 9   ? 152.736 143.261 150.131 1.00 252.29 ? 9   A   C C2    1 
ATOM   6009 N  N3    . A   C 3 9   ? 152.415 144.548 150.248 1.00 252.29 ? 9   A   C N3    1 
ATOM   6010 C  C4    . A   C 3 9   ? 151.100 144.693 150.490 1.00 252.29 ? 9   A   C C4    1 
ATOM   6011 P  P     . C   C 3 10  ? 150.142 148.947 146.240 1.00 317.67 ? 10  C   C P     1 
ATOM   6012 O  OP1   . C   C 3 10  ? 150.310 150.159 145.400 1.00 317.67 ? 10  C   C OP1   1 
ATOM   6013 O  OP2   . C   C 3 10  ? 148.902 148.138 146.120 1.00 317.67 ? 10  C   C OP2   1 
ATOM   6014 O  "O5'" . C   C 3 10  ? 151.390 147.991 145.982 1.00 317.67 ? 10  C   C "O5'" 1 
ATOM   6015 C  "C5'" . C   C 3 10  ? 152.713 148.503 146.012 1.00 317.67 ? 10  C   C "C5'" 1 
ATOM   6016 C  "C4'" . C   C 3 10  ? 153.740 147.407 145.866 1.00 317.67 ? 10  C   C "C4'" 1 
ATOM   6017 O  "O4'" . C   C 3 10  ? 153.648 146.482 146.981 1.00 317.67 ? 10  C   C "O4'" 1 
ATOM   6018 C  "C3'" . C   C 3 10  ? 153.597 146.517 144.644 1.00 317.67 ? 10  C   C "C3'" 1 
ATOM   6019 O  "O3'" . C   C 3 10  ? 154.109 147.109 143.464 1.00 317.67 ? 10  C   C "O3'" 1 
ATOM   6020 C  "C2'" . C   C 3 10  ? 154.341 145.258 145.066 1.00 317.67 ? 10  C   C "C2'" 1 
ATOM   6021 O  "O2'" . C   C 3 10  ? 155.745 145.443 144.953 1.00 317.67 ? 10  C   C "O2'" 1 
ATOM   6022 C  "C1'" . C   C 3 10  ? 153.985 145.179 146.551 1.00 317.67 ? 10  C   C "C1'" 1 
ATOM   6023 N  N1    . C   C 3 10  ? 152.841 144.274 146.809 1.00 317.67 ? 10  C   C N1    1 
ATOM   6024 C  C2    . C   C 3 10  ? 153.041 142.888 146.751 1.00 317.67 ? 10  C   C C2    1 
ATOM   6025 O  O2    . C   C 3 10  ? 154.172 142.461 146.476 1.00 317.67 ? 10  C   C O2    1 
ATOM   6026 N  N3    . C   C 3 10  ? 151.999 142.059 146.995 1.00 317.67 ? 10  C   C N3    1 
ATOM   6027 C  C4    . C   C 3 10  ? 150.802 142.568 147.285 1.00 317.67 ? 10  C   C C4    1 
ATOM   6028 N  N4    . C   C 3 10  ? 149.795 141.723 147.521 1.00 317.67 ? 10  C   C N4    1 
ATOM   6029 C  C5    . C   C 3 10  ? 150.573 143.972 147.353 1.00 317.67 ? 10  C   C C5    1 
ATOM   6030 C  C6    . C   C 3 10  ? 151.610 144.779 147.112 1.00 317.67 ? 10  C   C C6    1 
ATOM   6031 P  P     . U   C 3 11  ? 153.520 146.684 142.031 1.00 379.43 ? 11  U   C P     1 
ATOM   6032 O  OP1   . U   C 3 11  ? 154.095 147.594 141.008 1.00 379.43 ? 11  U   C OP1   1 
ATOM   6033 O  OP2   . U   C 3 11  ? 152.047 146.560 142.162 1.00 379.43 ? 11  U   C OP2   1 
ATOM   6034 O  "O5'" . U   C 3 11  ? 154.119 145.228 141.786 1.00 379.43 ? 11  U   C "O5'" 1 
ATOM   6035 C  "C5'" . U   C 3 11  ? 155.522 145.017 141.747 1.00 379.43 ? 11  U   C "C5'" 1 
ATOM   6036 C  "C4'" . U   C 3 11  ? 155.860 143.550 141.676 1.00 379.43 ? 11  U   C "C4'" 1 
ATOM   6037 O  "O4'" . U   C 3 11  ? 155.483 142.886 142.911 1.00 379.43 ? 11  U   C "O4'" 1 
ATOM   6038 C  "C3'" . U   C 3 11  ? 155.141 142.753 140.603 1.00 379.43 ? 11  U   C "C3'" 1 
ATOM   6039 O  "O3'" . U   C 3 11  ? 155.709 142.924 139.317 1.00 379.43 ? 11  U   C "O3'" 1 
ATOM   6040 C  "C2'" . U   C 3 11  ? 155.230 141.329 141.133 1.00 379.43 ? 11  U   C "C2'" 1 
ATOM   6041 O  "O2'" . U   C 3 11  ? 156.518 140.782 140.889 1.00 379.43 ? 11  U   C "O2'" 1 
ATOM   6042 C  "C1'" . U   C 3 11  ? 155.080 141.559 142.638 1.00 379.43 ? 11  U   C "C1'" 1 
ATOM   6043 N  N1    . U   C 3 11  ? 153.682 141.378 143.093 1.00 379.43 ? 11  U   C N1    1 
ATOM   6044 C  C2    . U   C 3 11  ? 153.214 140.086 143.250 1.00 379.43 ? 11  U   C C2    1 
ATOM   6045 O  O2    . U   C 3 11  ? 153.898 139.102 143.033 1.00 379.43 ? 11  U   C O2    1 
ATOM   6046 N  N3    . U   C 3 11  ? 151.912 139.983 143.673 1.00 379.43 ? 11  U   C N3    1 
ATOM   6047 C  C4    . U   C 3 11  ? 151.048 141.025 143.949 1.00 379.43 ? 11  U   C C4    1 
ATOM   6048 O  O4    . U   C 3 11  ? 149.899 140.790 144.324 1.00 379.43 ? 11  U   C O4    1 
ATOM   6049 C  C5    . U   C 3 11  ? 151.607 142.329 143.761 1.00 379.43 ? 11  U   C C5    1 
ATOM   6050 C  C6    . U   C 3 11  ? 152.871 142.457 143.351 1.00 379.43 ? 11  U   C C6    1 
ATOM   6051 P  P     . A   C 3 12  ? 154.765 142.919 138.017 1.00 470.00 ? 12  A   C P     1 
ATOM   6052 O  OP1   . A   C 3 12  ? 155.554 143.440 136.872 1.00 470.00 ? 12  A   C OP1   1 
ATOM   6053 O  OP2   . A   C 3 12  ? 153.478 143.566 138.380 1.00 470.00 ? 12  A   C OP2   1 
ATOM   6054 O  "O5'" . A   C 3 12  ? 154.485 141.374 137.762 1.00 470.00 ? 12  A   C "O5'" 1 
ATOM   6055 C  "C5'" . A   C 3 12  ? 155.561 140.458 137.633 1.00 470.00 ? 12  A   C "C5'" 1 
ATOM   6056 C  "C4'" . A   C 3 12  ? 155.091 139.032 137.754 1.00 470.00 ? 12  A   C "C4'" 1 
ATOM   6057 O  "O4'" . A   C 3 12  ? 154.711 138.743 139.125 1.00 470.00 ? 12  A   C "O4'" 1 
ATOM   6058 C  "C3'" . A   C 3 12  ? 153.854 138.668 136.952 1.00 470.00 ? 12  A   C "C3'" 1 
ATOM   6059 O  "O3'" . A   C 3 12  ? 154.120 138.448 135.579 1.00 470.00 ? 12  A   C "O3'" 1 
ATOM   6060 C  "C2'" . A   C 3 12  ? 153.343 137.438 137.689 1.00 470.00 ? 12  A   C "C2'" 1 
ATOM   6061 O  "O2'" . A   C 3 12  ? 154.119 136.297 137.358 1.00 470.00 ? 12  A   C "O2'" 1 
ATOM   6062 C  "C1'" . A   C 3 12  ? 153.637 137.822 139.139 1.00 470.00 ? 12  A   C "C1'" 1 
ATOM   6063 N  N9    . A   C 3 12  ? 152.472 138.462 139.774 1.00 470.00 ? 12  A   C N9    1 
ATOM   6064 C  C8    . A   C 3 12  ? 152.287 139.790 140.066 1.00 470.00 ? 12  A   C C8    1 
ATOM   6065 N  N7    . A   C 3 12  ? 151.131 140.051 140.624 1.00 470.00 ? 12  A   C N7    1 
ATOM   6066 C  C5    . A   C 3 12  ? 150.512 138.811 140.703 1.00 470.00 ? 12  A   C C5    1 
ATOM   6067 C  C6    . A   C 3 12  ? 149.259 138.405 141.193 1.00 470.00 ? 12  A   C C6    1 
ATOM   6068 N  N6    . A   C 3 12  ? 148.371 139.246 141.727 1.00 470.00 ? 12  A   C N6    1 
ATOM   6069 N  N1    . A   C 3 12  ? 148.946 137.091 141.123 1.00 470.00 ? 12  A   C N1    1 
ATOM   6070 C  C2    . A   C 3 12  ? 149.840 136.249 140.589 1.00 470.00 ? 12  A   C C2    1 
ATOM   6071 N  N3    . A   C 3 12  ? 151.047 136.511 140.092 1.00 470.00 ? 12  A   C N3    1 
ATOM   6072 C  C4    . A   C 3 12  ? 151.326 137.824 140.180 1.00 470.00 ? 12  A   C C4    1 
ATOM   6073 P  P     . A   C 3 13  ? 153.002 138.805 134.482 1.00 545.52 ? 13  A   C P     1 
ATOM   6074 O  OP1   . A   C 3 13  ? 153.658 138.863 133.151 1.00 545.52 ? 13  A   C OP1   1 
ATOM   6075 O  OP2   . A   C 3 13  ? 152.235 139.978 134.975 1.00 545.52 ? 13  A   C OP2   1 
ATOM   6076 O  "O5'" . A   C 3 13  ? 152.035 137.542 134.506 1.00 545.52 ? 13  A   C "O5'" 1 
ATOM   6077 C  "C5'" . A   C 3 13  ? 152.556 136.229 134.369 1.00 545.52 ? 13  A   C "C5'" 1 
ATOM   6078 C  "C4'" . A   C 3 13  ? 151.545 135.188 134.774 1.00 545.52 ? 13  A   C "C4'" 1 
ATOM   6079 O  "O4'" . A   C 3 13  ? 151.327 135.234 136.208 1.00 545.52 ? 13  A   C "O4'" 1 
ATOM   6080 C  "C3'" . A   C 3 13  ? 150.153 135.354 134.188 1.00 545.52 ? 13  A   C "C3'" 1 
ATOM   6081 O  "O3'" . A   C 3 13  ? 150.056 134.882 132.857 1.00 545.52 ? 13  A   C "O3'" 1 
ATOM   6082 C  "C2'" . A   C 3 13  ? 149.287 134.588 135.178 1.00 545.52 ? 13  A   C "C2'" 1 
ATOM   6083 O  "O2'" . A   C 3 13  ? 149.391 133.190 134.959 1.00 545.52 ? 13  A   C "O2'" 1 
ATOM   6084 C  "C1'" . A   C 3 13  ? 149.979 134.924 136.499 1.00 545.52 ? 13  A   C "C1'" 1 
ATOM   6085 N  N9    . A   C 3 13  ? 149.365 136.090 137.162 1.00 545.52 ? 13  A   C N9    1 
ATOM   6086 C  C8    . A   C 3 13  ? 149.919 137.333 137.331 1.00 545.52 ? 13  A   C C8    1 
ATOM   6087 N  N7    . A   C 3 13  ? 149.144 138.180 137.960 1.00 545.52 ? 13  A   C N7    1 
ATOM   6088 C  C5    . A   C 3 13  ? 147.995 137.446 138.219 1.00 545.52 ? 13  A   C C5    1 
ATOM   6089 C  C6    . A   C 3 13  ? 146.794 137.778 138.866 1.00 545.52 ? 13  A   C C6    1 
ATOM   6090 N  N6    . A   C 3 13  ? 146.543 138.984 139.379 1.00 545.52 ? 13  A   C N6    1 
ATOM   6091 N  N1    . A   C 3 13  ? 145.845 136.823 138.963 1.00 545.52 ? 13  A   C N1    1 
ATOM   6092 C  C2    . A   C 3 13  ? 146.098 135.613 138.446 1.00 545.52 ? 13  A   C C2    1 
ATOM   6093 N  N3    . A   C 3 13  ? 147.192 135.180 137.819 1.00 545.52 ? 13  A   C N3    1 
ATOM   6094 C  C4    . A   C 3 13  ? 148.118 136.154 137.739 1.00 545.52 ? 13  A   C C4    1 
ATOM   6095 P  P     . C   C 3 14  ? 149.033 135.576 131.832 1.00 649.76 ? 14  C   C P     1 
ATOM   6096 O  OP1   . C   C 3 14  ? 149.376 135.117 130.462 1.00 649.76 ? 14  C   C OP1   1 
ATOM   6097 O  OP2   . C   C 3 14  ? 148.990 137.030 132.132 1.00 649.76 ? 14  C   C OP2   1 
ATOM   6098 O  "O5'" . C   C 3 14  ? 147.624 134.951 132.227 1.00 649.76 ? 14  C   C "O5'" 1 
ATOM   6099 C  "C5'" . C   C 3 14  ? 147.427 133.544 132.225 1.00 649.76 ? 14  C   C "C5'" 1 
ATOM   6100 C  "C4'" . C   C 3 14  ? 146.114 133.175 132.865 1.00 649.76 ? 14  C   C "C4'" 1 
ATOM   6101 O  "O4'" . C   C 3 14  ? 146.144 133.504 134.280 1.00 649.76 ? 14  C   C "O4'" 1 
ATOM   6102 C  "C3'" . C   C 3 14  ? 144.895 133.915 132.341 1.00 649.76 ? 14  C   C "C3'" 1 
ATOM   6103 O  "O3'" . C   C 3 14  ? 144.397 133.373 131.131 1.00 649.76 ? 14  C   C "O3'" 1 
ATOM   6104 C  "C2'" . C   C 3 14  ? 143.921 133.817 133.506 1.00 649.76 ? 14  C   C "C2'" 1 
ATOM   6105 O  "O2'" . C   C 3 14  ? 143.318 132.531 133.547 1.00 649.76 ? 14  C   C "O2'" 1 
ATOM   6106 C  "C1'" . C   C 3 14  ? 144.868 133.944 134.700 1.00 649.76 ? 14  C   C "C1'" 1 
ATOM   6107 N  N1    . C   C 3 14  ? 144.990 135.344 135.173 1.00 649.76 ? 14  C   C N1    1 
ATOM   6108 C  C2    . C   C 3 14  ? 143.921 135.969 135.828 1.00 649.76 ? 14  C   C C2    1 
ATOM   6109 O  O2    . C   C 3 14  ? 142.861 135.344 135.986 1.00 649.76 ? 14  C   C O2    1 
ATOM   6110 N  N3    . C   C 3 14  ? 144.067 137.251 136.247 1.00 649.76 ? 14  C   C N3    1 
ATOM   6111 C  C4    . C   C 3 14  ? 145.218 137.895 136.047 1.00 649.76 ? 14  C   C C4    1 
ATOM   6112 N  N4    . C   C 3 14  ? 145.332 139.153 136.476 1.00 649.76 ? 14  C   C N4    1 
ATOM   6113 C  C5    . C   C 3 14  ? 146.319 137.279 135.393 1.00 649.76 ? 14  C   C C5    1 
ATOM   6114 C  C6    . C   C 3 14  ? 146.162 136.018 134.982 1.00 649.76 ? 14  C   C C6    1 
ATOM   6115 P  P     . U   C 3 15  ? 143.732 134.337 130.032 1.00 864.48 ? 15  U   C P     1 
ATOM   6116 O  OP1   . U   C 3 15  ? 143.559 133.560 128.778 1.00 864.48 ? 15  U   C OP1   1 
ATOM   6117 O  OP2   . U   C 3 15  ? 144.502 135.607 130.009 1.00 864.48 ? 15  U   C OP2   1 
ATOM   6118 O  "O5'" . U   C 3 15  ? 142.287 134.650 130.624 1.00 864.48 ? 15  U   C "O5'" 1 
ATOM   6119 C  "C5'" . U   C 3 15  ? 141.390 133.600 130.950 1.00 864.48 ? 15  U   C "C5'" 1 
ATOM   6120 C  "C4'" . U   C 3 15  ? 140.188 134.117 131.698 1.00 864.48 ? 15  U   C "C4'" 1 
ATOM   6121 O  "O4'" . U   C 3 15  ? 140.583 134.567 133.020 1.00 864.48 ? 15  U   C "O4'" 1 
ATOM   6122 C  "C3'" . U   C 3 15  ? 139.501 135.327 131.085 1.00 864.48 ? 15  U   C "C3'" 1 
ATOM   6123 O  "O3'" . U   C 3 15  ? 138.627 134.987 130.025 1.00 864.48 ? 15  U   C "O3'" 1 
ATOM   6124 C  "C2'" . U   C 3 15  ? 138.799 135.953 132.283 1.00 864.48 ? 15  U   C "C2'" 1 
ATOM   6125 O  "O2'" . U   C 3 15  ? 137.603 135.250 132.586 1.00 864.48 ? 15  U   C "O2'" 1 
ATOM   6126 C  "C1'" . U   C 3 15  ? 139.811 135.689 133.399 1.00 864.48 ? 15  U   C "C1'" 1 
ATOM   6127 N  N1    . U   C 3 15  ? 140.723 136.834 133.624 1.00 864.48 ? 15  U   C N1    1 
ATOM   6128 C  C2    . U   C 3 15  ? 140.233 137.986 134.215 1.00 864.48 ? 15  U   C C2    1 
ATOM   6129 O  O2    . U   C 3 15  ? 139.066 138.128 134.539 1.00 864.48 ? 15  U   C O2    1 
ATOM   6130 N  N3    . U   C 3 15  ? 141.155 138.994 134.383 1.00 864.48 ? 15  U   C N3    1 
ATOM   6131 C  C4    . U   C 3 15  ? 142.494 138.957 134.049 1.00 864.48 ? 15  U   C C4    1 
ATOM   6132 O  O4    . U   C 3 15  ? 143.217 139.931 134.261 1.00 864.48 ? 15  U   C O4    1 
ATOM   6133 C  C5    . U   C 3 15  ? 142.921 137.732 133.451 1.00 864.48 ? 15  U   C C5    1 
ATOM   6134 C  C6    . U   C 3 15  ? 142.047 136.739 133.274 1.00 864.48 ? 15  U   C C6    1 
ATOM   6135 P  P     . A   C 3 16  ? 138.448 135.981 128.775 1.00 1027.2 ? 16  A   C P     1 
ATOM   6136 O  OP1   . A   C 3 16  ? 137.659 135.275 127.735 1.00 1027.2 ? 16  A   C OP1   1 
ATOM   6137 O  OP2   . A   C 3 16  ? 139.783 136.536 128.434 1.00 1027.2 ? 16  A   C OP2   1 
ATOM   6138 O  "O5'" . A   C 3 16  ? 137.554 137.166 129.354 1.00 1027.2 ? 16  A   C "O5'" 1 
ATOM   6139 C  "C5'" . A   C 3 16  ? 136.254 136.913 129.864 1.00 1027.2 ? 16  A   C "C5'" 1 
ATOM   6140 C  "C4'" . A   C 3 16  ? 135.703 138.110 130.595 1.00 1027.2 ? 16  A   C "C4'" 1 
ATOM   6141 O  "O4'" . A   C 3 16  ? 136.431 138.316 131.833 1.00 1027.2 ? 16  A   C "O4'" 1 
ATOM   6142 C  "C3'" . A   C 3 16  ? 135.821 139.443 129.875 1.00 1027.2 ? 16  A   C "C3'" 1 
ATOM   6143 O  "O3'" . A   C 3 16  ? 134.816 139.635 128.895 1.00 1027.2 ? 16  A   C "O3'" 1 
ATOM   6144 C  "C2'" . A   C 3 16  ? 135.759 140.444 131.021 1.00 1027.2 ? 16  A   C "C2'" 1 
ATOM   6145 O  "O2'" . A   C 3 16  ? 134.420 140.624 131.458 1.00 1027.2 ? 16  A   C "O2'" 1 
ATOM   6146 C  "C1'" . A   C 3 16  ? 136.527 139.698 132.112 1.00 1027.2 ? 16  A   C "C1'" 1 
ATOM   6147 N  N9    . A   C 3 16  ? 137.952 140.074 132.140 1.00 1027.2 ? 16  A   C N9    1 
ATOM   6148 C  C8    . A   C 3 16  ? 139.023 139.303 131.772 1.00 1027.2 ? 16  A   C C8    1 
ATOM   6149 N  N7    . A   C 3 16  ? 140.182 139.898 131.910 1.00 1027.2 ? 16  A   C N7    1 
ATOM   6150 C  C5    . A   C 3 16  ? 139.850 141.154 132.396 1.00 1027.2 ? 16  A   C C5    1 
ATOM   6151 C  C6    . A   C 3 16  ? 140.635 142.266 132.744 1.00 1027.2 ? 16  A   C C6    1 
ATOM   6152 N  N6    . A   C 3 16  ? 141.965 142.288 132.652 1.00 1027.2 ? 16  A   C N6    1 
ATOM   6153 N  N1    . A   C 3 16  ? 139.998 143.371 133.190 1.00 1027.2 ? 16  A   C N1    1 
ATOM   6154 C  C2    . A   C 3 16  ? 138.661 143.345 133.280 1.00 1027.2 ? 16  A   C C2    1 
ATOM   6155 N  N3    . A   C 3 16  ? 137.815 142.361 132.983 1.00 1027.2 ? 16  A   C N3    1 
ATOM   6156 C  C4    . A   C 3 16  ? 138.481 141.277 132.543 1.00 1027.2 ? 16  A   C C4    1 
ATOM   6157 P  P     . U   C 3 17  ? 135.131 140.500 127.579 1.00 1027.2 ? 17  U   C P     1 
ATOM   6158 O  OP1   . U   C 3 17  ? 134.013 140.306 126.620 1.00 1027.2 ? 17  U   C OP1   1 
ATOM   6159 O  OP2   . U   C 3 17  ? 136.522 140.203 127.155 1.00 1027.2 ? 17  U   C OP2   1 
ATOM   6160 O  "O5'" . U   C 3 17  ? 135.085 142.007 128.093 1.00 1027.2 ? 17  U   C "O5'" 1 
ATOM   6161 C  "C5'" . U   C 3 17  ? 133.921 142.530 128.715 1.00 1027.2 ? 17  U   C "C5'" 1 
ATOM   6162 C  "C4'" . U   C 3 17  ? 134.169 143.906 129.279 1.00 1027.2 ? 17  U   C "C4'" 1 
ATOM   6163 O  "O4'" . U   C 3 17  ? 135.105 143.826 130.386 1.00 1027.2 ? 17  U   C "O4'" 1 
ATOM   6164 C  "C3'" . U   C 3 17  ? 134.807 144.906 128.327 1.00 1027.2 ? 17  U   C "C3'" 1 
ATOM   6165 O  "O3'" . U   C 3 17  ? 133.870 145.499 127.447 1.00 1027.2 ? 17  U   C "O3'" 1 
ATOM   6166 C  "C2'" . U   C 3 17  ? 135.468 145.896 129.276 1.00 1027.2 ? 17  U   C "C2'" 1 
ATOM   6167 O  "O2'" . U   C 3 17  ? 134.511 146.805 129.800 1.00 1027.2 ? 17  U   C "O2'" 1 
ATOM   6168 C  "C1'" . U   C 3 17  ? 135.927 144.975 130.406 1.00 1027.2 ? 17  U   C "C1'" 1 
ATOM   6169 N  N1    . U   C 3 17  ? 137.338 144.548 130.257 1.00 1027.2 ? 17  U   C N1    1 
ATOM   6170 C  C2    . U   C 3 17  ? 138.345 145.460 130.522 1.00 1027.2 ? 17  U   C C2    1 
ATOM   6171 O  O2    . U   C 3 17  ? 138.130 146.614 130.853 1.00 1027.2 ? 17  U   C O2    1 
ATOM   6172 N  N3    . U   C 3 17  ? 139.624 144.978 130.367 1.00 1027.2 ? 17  U   C N3    1 
ATOM   6173 C  C4    . U   C 3 17  ? 139.989 143.700 129.991 1.00 1027.2 ? 17  U   C C4    1 
ATOM   6174 O  O4    . U   C 3 17  ? 141.179 143.398 129.894 1.00 1027.2 ? 17  U   C O4    1 
ATOM   6175 C  C5    . U   C 3 17  ? 138.891 142.819 129.743 1.00 1027.2 ? 17  U   C C5    1 
ATOM   6176 C  C6    . U   C 3 17  ? 137.639 143.259 129.886 1.00 1027.2 ? 17  U   C C6    1 
ATOM   6177 P  P     . C   C 3 18  ? 134.339 146.033 126.006 1.00 1027.2 ? 18  C   C P     1 
ATOM   6178 O  OP1   . C   C 3 18  ? 133.125 146.461 125.264 1.00 1027.2 ? 18  C   C OP1   1 
ATOM   6179 O  OP2   . C   C 3 18  ? 135.249 145.025 125.406 1.00 1027.2 ? 18  C   C OP2   1 
ATOM   6180 O  "O5'" . C   C 3 18  ? 135.193 147.335 126.341 1.00 1027.2 ? 18  C   C "O5'" 1 
ATOM   6181 C  "C5'" . C   C 3 18  ? 134.580 148.477 126.920 1.00 1027.2 ? 18  C   C "C5'" 1 
ATOM   6182 C  "C4'" . C   C 3 18  ? 135.602 149.522 127.289 1.00 1027.2 ? 18  C   C "C4'" 1 
ATOM   6183 O  "O4'" . C   C 3 18  ? 136.502 149.002 128.300 1.00 1027.2 ? 18  C   C "O4'" 1 
ATOM   6184 C  "C3'" . C   C 3 18  ? 136.527 149.967 126.168 1.00 1027.2 ? 18  C   C "C3'" 1 
ATOM   6185 O  "O3'" . C   C 3 18  ? 135.929 150.923 125.310 1.00 1027.2 ? 18  C   C "O3'" 1 
ATOM   6186 C  "C2'" . C   C 3 18  ? 137.737 150.497 126.925 1.00 1027.2 ? 18  C   C "C2'" 1 
ATOM   6187 O  "O2'" . C   C 3 18  ? 137.488 151.806 127.417 1.00 1027.2 ? 18  C   C "O2'" 1 
ATOM   6188 C  "C1'" . C   C 3 18  ? 137.795 149.540 128.116 1.00 1027.2 ? 18  C   C "C1'" 1 
ATOM   6189 N  N1    . C   C 3 18  ? 138.756 148.429 127.916 1.00 1027.2 ? 18  C   C N1    1 
ATOM   6190 C  C2    . C   C 3 18  ? 140.127 148.677 128.038 1.00 1027.2 ? 18  C   C C2    1 
ATOM   6191 O  O2    . C   C 3 18  ? 140.501 149.833 128.288 1.00 1027.2 ? 18  C   C O2    1 
ATOM   6192 N  N3    . C   C 3 18  ? 141.005 147.659 127.867 1.00 1027.2 ? 18  C   C N3    1 
ATOM   6193 C  C4    . C   C 3 18  ? 140.557 146.432 127.598 1.00 1027.2 ? 18  C   C C4    1 
ATOM   6194 N  N4    . C   C 3 18  ? 141.449 145.451 127.438 1.00 1027.2 ? 18  C   C N4    1 
ATOM   6195 C  C5    . C   C 3 18  ? 139.166 146.150 127.473 1.00 1027.2 ? 18  C   C C5    1 
ATOM   6196 C  C6    . C   C 3 18  ? 138.312 147.166 127.644 1.00 1027.2 ? 18  C   C C6    1 
ATOM   6197 P  P     . A   C 3 19  ? 136.401 151.038 123.778 1.00 1027.2 ? 19  A   C P     1 
ATOM   6198 O  OP1   . A   C 3 19  ? 135.464 151.953 123.078 1.00 1027.2 ? 19  A   C OP1   1 
ATOM   6199 O  OP2   . A   C 3 19  ? 136.611 149.662 123.258 1.00 1027.2 ? 19  A   C OP2   1 
ATOM   6200 O  "O5'" . A   C 3 19  ? 137.818 151.755 123.867 1.00 1027.2 ? 19  A   C "O5'" 1 
ATOM   6201 C  "C5'" . A   C 3 19  ? 137.947 153.044 124.450 1.00 1027.2 ? 19  A   C "C5'" 1 
ATOM   6202 C  "C4'" . A   C 3 19  ? 139.393 153.416 124.654 1.00 1027.2 ? 19  A   C "C4'" 1 
ATOM   6203 O  "O4'" . A   C 3 19  ? 139.977 152.603 125.706 1.00 1027.2 ? 19  A   C "O4'" 1 
ATOM   6204 C  "C3'" . A   C 3 19  ? 140.309 153.184 123.466 1.00 1027.2 ? 19  A   C "C3'" 1 
ATOM   6205 O  "O3'" . A   C 3 19  ? 140.210 154.198 122.482 1.00 1027.2 ? 19  A   C "O3'" 1 
ATOM   6206 C  "C2'" . A   C 3 19  ? 141.679 153.089 124.123 1.00 1027.2 ? 19  A   C "C2'" 1 
ATOM   6207 O  "O2'" . A   C 3 19  ? 142.161 154.379 124.468 1.00 1027.2 ? 19  A   C "O2'" 1 
ATOM   6208 C  "C1'" . A   C 3 19  ? 141.335 152.341 125.411 1.00 1027.2 ? 19  A   C "C1'" 1 
ATOM   6209 N  N9    . A   C 3 19  ? 141.510 150.884 125.258 1.00 1027.2 ? 19  A   C N9    1 
ATOM   6210 C  C8    . A   C 3 19  ? 140.537 149.935 125.073 1.00 1027.2 ? 19  A   C C8    1 
ATOM   6211 N  N7    . A   C 3 19  ? 140.999 148.714 124.961 1.00 1027.2 ? 19  A   C N7    1 
ATOM   6212 C  C5    . A   C 3 19  ? 142.373 148.870 125.075 1.00 1027.2 ? 19  A   C C5    1 
ATOM   6213 C  C6    . A   C 3 19  ? 143.435 147.949 125.039 1.00 1027.2 ? 19  A   C C6    1 
ATOM   6214 N  N6    . A   C 3 19  ? 143.268 146.636 124.871 1.00 1027.2 ? 19  A   C N6    1 
ATOM   6215 N  N1    . A   C 3 19  ? 144.689 148.430 125.180 1.00 1027.2 ? 19  A   C N1    1 
ATOM   6216 C  C2    . A   C 3 19  ? 144.857 149.748 125.348 1.00 1027.2 ? 19  A   C C2    1 
ATOM   6217 N  N3    . A   C 3 19  ? 143.939 150.711 125.399 1.00 1027.2 ? 19  A   C N3    1 
ATOM   6218 C  C4    . A   C 3 19  ? 142.704 150.201 125.255 1.00 1027.2 ? 19  A   C C4    1 
ATOM   6219 P  P     . G   C 3 20  ? 140.207 153.802 120.926 1.00 1027.2 ? 20  G   C P     1 
ATOM   6220 O  OP1   . G   C 3 20  ? 139.603 154.923 120.160 1.00 1027.2 ? 20  G   C OP1   1 
ATOM   6221 O  OP2   . G   C 3 20  ? 139.635 152.437 120.800 1.00 1027.2 ? 20  G   C OP2   1 
ATOM   6222 O  "O5'" . G   C 3 20  ? 141.753 153.723 120.555 1.00 1027.2 ? 20  G   C "O5'" 1 
ATOM   6223 C  "C5'" . G   C 3 20  ? 142.626 154.792 120.882 1.00 1027.2 ? 20  G   C "C5'" 1 
ATOM   6224 C  "C4'" . G   C 3 20  ? 144.064 154.343 120.933 1.00 1027.2 ? 20  G   C "C4'" 1 
ATOM   6225 O  "O4'" . G   C 3 20  ? 144.279 153.477 122.079 1.00 1027.2 ? 20  G   C "O4'" 1 
ATOM   6226 C  "C3'" . G   C 3 20  ? 144.551 153.514 119.758 1.00 1027.2 ? 20  G   C "C3'" 1 
ATOM   6227 O  "O3'" . G   C 3 20  ? 144.853 154.291 118.613 1.00 1027.2 ? 20  G   C "O3'" 1 
ATOM   6228 C  "C2'" . G   C 3 20  ? 145.755 152.791 120.347 1.00 1027.2 ? 20  G   C "C2'" 1 
ATOM   6229 O  "O2'" . G   C 3 20  ? 146.877 153.658 120.415 1.00 1027.2 ? 20  G   C "O2'" 1 
ATOM   6230 C  "C1'" . G   C 3 20  ? 145.269 152.516 121.773 1.00 1027.2 ? 20  G   C "C1'" 1 
ATOM   6231 N  N9    . G   C 3 20  ? 144.684 151.167 121.900 1.00 1027.2 ? 20  G   C N9    1 
ATOM   6232 C  C8    . G   C 3 20  ? 143.357 150.827 121.999 1.00 1027.2 ? 20  G   C C8    1 
ATOM   6233 N  N7    . G   C 3 20  ? 143.166 149.537 122.091 1.00 1027.2 ? 20  G   C N7    1 
ATOM   6234 C  C5    . G   C 3 20  ? 144.444 148.993 122.050 1.00 1027.2 ? 20  G   C C5    1 
ATOM   6235 C  C6    . G   C 3 20  ? 144.876 147.641 122.105 1.00 1027.2 ? 20  G   C C6    1 
ATOM   6236 O  O6    . G   C 3 20  ? 144.186 146.621 122.217 1.00 1027.2 ? 20  G   C O6    1 
ATOM   6237 N  N1    . G   C 3 20  ? 146.263 147.538 122.030 1.00 1027.2 ? 20  G   C N1    1 
ATOM   6238 C  C2    . G   C 3 20  ? 147.120 148.604 121.910 1.00 1027.2 ? 20  G   C C2    1 
ATOM   6239 N  N2    . G   C 3 20  ? 148.428 148.316 121.849 1.00 1027.2 ? 20  G   C N2    1 
ATOM   6240 N  N3    . G   C 3 20  ? 146.730 149.867 121.856 1.00 1027.2 ? 20  G   C N3    1 
ATOM   6241 C  C4    . G   C 3 20  ? 145.390 149.988 121.931 1.00 1027.2 ? 20  G   C C4    1 
ATOM   6242 P  P     . G   C 3 21  ? 144.623 153.681 117.145 1.00 1027.2 ? 21  G   C P     1 
ATOM   6243 O  OP1   . G   C 3 21  ? 144.672 154.798 116.167 1.00 1027.2 ? 21  G   C OP1   1 
ATOM   6244 O  OP2   . G   C 3 21  ? 143.428 152.801 117.193 1.00 1027.2 ? 21  G   C OP2   1 
ATOM   6245 O  "O5'" . G   C 3 21  ? 145.902 152.760 116.911 1.00 1027.2 ? 21  G   C "O5'" 1 
ATOM   6246 C  "C5'" . G   C 3 21  ? 147.210 153.310 116.964 1.00 1027.2 ? 21  G   C "C5'" 1 
ATOM   6247 C  "C4'" . G   C 3 21  ? 148.267 152.234 116.939 1.00 1027.2 ? 21  G   C "C4'" 1 
ATOM   6248 O  "O4'" . G   C 3 21  ? 148.244 151.486 118.183 1.00 1027.2 ? 21  G   C "O4'" 1 
ATOM   6249 C  "C3'" . G   C 3 21  ? 148.110 151.169 115.867 1.00 1027.2 ? 21  G   C "C3'" 1 
ATOM   6250 O  "O3'" . G   C 3 21  ? 148.574 151.591 114.596 1.00 1027.2 ? 21  G   C "O3'" 1 
ATOM   6251 C  "C2'" . G   C 3 21  ? 148.892 149.999 116.447 1.00 1027.2 ? 21  G   C "C2'" 1 
ATOM   6252 O  "O2'" . G   C 3 21  ? 150.288 150.189 116.268 1.00 1027.2 ? 21  G   C "O2'" 1 
ATOM   6253 C  "C1'" . G   C 3 21  ? 148.573 150.134 117.937 1.00 1027.2 ? 21  G   C "C1'" 1 
ATOM   6254 N  N9    . G   C 3 21  ? 147.427 149.294 118.335 1.00 1027.2 ? 21  G   C N9    1 
ATOM   6255 C  C8    . G   C 3 21  ? 146.217 149.730 118.814 1.00 1027.2 ? 21  G   C C8    1 
ATOM   6256 N  N7    . G   C 3 21  ? 145.390 148.759 119.086 1.00 1027.2 ? 21  G   C N7    1 
ATOM   6257 C  C5    . G   C 3 21  ? 146.093 147.608 118.766 1.00 1027.2 ? 21  G   C C5    1 
ATOM   6258 C  C6    . G   C 3 21  ? 145.706 146.245 118.846 1.00 1027.2 ? 21  G   C C6    1 
ATOM   6259 O  O6    . G   C 3 21  ? 144.631 145.776 119.239 1.00 1027.2 ? 21  G   C O6    1 
ATOM   6260 N  N1    . G   C 3 21  ? 146.725 145.398 118.421 1.00 1027.2 ? 21  G   C N1    1 
ATOM   6261 C  C2    . G   C 3 21  ? 147.955 145.811 117.973 1.00 1027.2 ? 21  G   C C2    1 
ATOM   6262 N  N2    . G   C 3 21  ? 148.804 144.844 117.599 1.00 1027.2 ? 21  G   C N2    1 
ATOM   6263 N  N3    . G   C 3 21  ? 148.327 147.079 117.892 1.00 1027.2 ? 21  G   C N3    1 
ATOM   6264 C  C4    . G   C 3 21  ? 147.354 147.919 118.301 1.00 1027.2 ? 21  G   C C4    1 
ATOM   6265 P  P     . A   C 3 22  ? 147.826 151.105 113.260 1.00 1027.2 ? 22  A   C P     1 
ATOM   6266 O  OP1   . A   C 3 22  ? 148.261 151.981 112.142 1.00 1027.2 ? 22  A   C OP1   1 
ATOM   6267 O  OP2   . A   C 3 22  ? 146.378 150.972 113.566 1.00 1027.2 ? 22  A   C OP2   1 
ATOM   6268 O  "O5'" . A   C 3 22  ? 148.409 149.646 113.000 1.00 1027.2 ? 22  A   C "O5'" 1 
ATOM   6269 C  "C5'" . A   C 3 22  ? 149.801 149.441 112.803 1.00 1027.2 ? 22  A   C "C5'" 1 
ATOM   6270 C  "C4'" . A   C 3 22  ? 150.148 147.973 112.816 1.00 1027.2 ? 22  A   C "C4'" 1 
ATOM   6271 O  "O4'" . A   C 3 22  ? 149.904 147.425 114.137 1.00 1027.2 ? 22  A   C "O4'" 1 
ATOM   6272 C  "C3'" . A   C 3 22  ? 149.329 147.091 111.887 1.00 1027.2 ? 22  A   C "C3'" 1 
ATOM   6273 O  "O3'" . A   C 3 22  ? 149.805 147.111 110.552 1.00 1027.2 ? 22  A   C "O3'" 1 
ATOM   6274 C  "C2'" . A   C 3 22  ? 149.425 145.724 112.549 1.00 1027.2 ? 22  A   C "C2'" 1 
ATOM   6275 O  "O2'" . A   C 3 22  ? 150.671 145.110 112.253 1.00 1027.2 ? 22  A   C "O2'" 1 
ATOM   6276 C  "C1'" . A   C 3 22  ? 149.415 146.104 114.030 1.00 1027.2 ? 22  A   C "C1'" 1 
ATOM   6277 N  N9    . A   C 3 22  ? 148.059 146.066 114.609 1.00 1027.2 ? 22  A   C N9    1 
ATOM   6278 C  C8    . A   C 3 22  ? 147.340 147.133 115.085 1.00 1027.2 ? 22  A   C C8    1 
ATOM   6279 N  N7    . A   C 3 22  ? 146.161 146.813 115.556 1.00 1027.2 ? 22  A   C N7    1 
ATOM   6280 C  C5    . A   C 3 22  ? 146.095 145.440 115.372 1.00 1027.2 ? 22  A   C C5    1 
ATOM   6281 C  C6    . A   C 3 22  ? 145.094 144.500 115.668 1.00 1027.2 ? 22  A   C C6    1 
ATOM   6282 N  N6    . A   C 3 22  ? 143.926 144.823 116.227 1.00 1027.2 ? 22  A   C N6    1 
ATOM   6283 N  N1    . A   C 3 22  ? 145.334 143.207 115.365 1.00 1027.2 ? 22  A   C N1    1 
ATOM   6284 C  C2    . A   C 3 22  ? 146.508 142.888 114.804 1.00 1027.2 ? 22  A   C C2    1 
ATOM   6285 N  N3    . A   C 3 22  ? 147.528 143.682 114.479 1.00 1027.2 ? 22  A   C N3    1 
ATOM   6286 C  C4    . A   C 3 22  ? 147.259 144.962 114.796 1.00 1027.2 ? 22  A   C C4    1 
ATOM   6287 P  P     . C   C 3 23  ? 148.788 146.908 109.324 1.00 1027.2 ? 23  C   C P     1 
ATOM   6288 O  OP1   . C   C 3 23  ? 149.529 147.193 108.070 1.00 1027.2 ? 23  C   C OP1   1 
ATOM   6289 O  OP2   . C   C 3 23  ? 147.538 147.654 109.624 1.00 1027.2 ? 23  C   C OP2   1 
ATOM   6290 O  "O5'" . C   C 3 23  ? 148.455 145.351 109.354 1.00 1027.2 ? 23  C   C "O5'" 1 
ATOM   6291 C  "C5'" . C   C 3 23  ? 149.434 144.387 108.996 1.00 1027.2 ? 23  C   C "C5'" 1 
ATOM   6292 C  "C4'" . C   C 3 23  ? 148.904 142.984 109.150 1.00 1027.2 ? 23  C   C "C4'" 1 
ATOM   6293 O  "O4'" . C   C 3 23  ? 148.523 142.757 110.532 1.00 1027.2 ? 23  C   C "O4'" 1 
ATOM   6294 C  "C3'" . C   C 3 23  ? 147.647 142.661 108.356 1.00 1027.2 ? 23  C   C "C3'" 1 
ATOM   6295 O  "O3'" . C   C 3 23  ? 147.920 142.318 107.009 1.00 1027.2 ? 23  C   C "O3'" 1 
ATOM   6296 C  "C2'" . C   C 3 23  ? 147.025 141.527 109.158 1.00 1027.2 ? 23  C   C "C2'" 1 
ATOM   6297 O  "O2'" . C   C 3 23  ? 147.674 140.297 108.874 1.00 1027.2 ? 23  C   C "O2'" 1 
ATOM   6298 C  "C1'" . C   C 3 23  ? 147.375 141.937 110.588 1.00 1027.2 ? 23  C   C "C1'" 1 
ATOM   6299 N  N1    . C   C 3 23  ? 146.288 142.698 111.252 1.00 1027.2 ? 23  C   C N1    1 
ATOM   6300 C  C2    . C   C 3 23  ? 145.114 142.050 111.657 1.00 1027.2 ? 23  C   C C2    1 
ATOM   6301 O  O2    . C   C 3 23  ? 144.981 140.837 111.434 1.00 1027.2 ? 23  C   C O2    1 
ATOM   6302 N  N3    . C   C 3 23  ? 144.141 142.767 112.270 1.00 1027.2 ? 23  C   C N3    1 
ATOM   6303 C  C4    . C   C 3 23  ? 144.309 144.070 112.495 1.00 1027.2 ? 23  C   C C4    1 
ATOM   6304 N  N4    . C   C 3 23  ? 143.330 144.742 113.106 1.00 1027.2 ? 23  C   C N4    1 
ATOM   6305 C  C5    . C   C 3 23  ? 145.495 144.752 112.103 1.00 1027.2 ? 23  C   C C5    1 
ATOM   6306 C  C6    . C   C 3 23  ? 146.448 144.034 111.497 1.00 1027.2 ? 23  C   C C6    1 
ATOM   6307 P  P     . G   C 3 24  ? 146.795 142.512 105.877 1.00 1027.2 ? 24  G   C P     1 
ATOM   6308 O  OP1   . G   C 3 24  ? 147.423 142.227 104.562 1.00 1027.2 ? 24  G   C OP1   1 
ATOM   6309 O  OP2   . G   C 3 24  ? 146.128 143.819 106.104 1.00 1027.2 ? 24  G   C OP2   1 
ATOM   6310 O  "O5'" . G   C 3 24  ? 145.739 141.356 106.177 1.00 1027.2 ? 24  G   C "O5'" 1 
ATOM   6311 C  "C5'" . G   C 3 24  ? 146.043 139.996 105.901 1.00 1027.2 ? 24  G   C "C5'" 1 
ATOM   6312 C  "C4'" . G   C 3 24  ? 144.933 139.079 106.351 1.00 1027.2 ? 24  G   C "C4'" 1 
ATOM   6313 O  "O4'" . G   C 3 24  ? 144.755 139.193 107.786 1.00 1027.2 ? 24  G   C "O4'" 1 
ATOM   6314 C  "C3'" . G   C 3 24  ? 143.553 139.376 105.779 1.00 1027.2 ? 24  G   C "C3'" 1 
ATOM   6315 O  "O3'" . G   C 3 24  ? 143.368 138.829 104.485 1.00 1027.2 ? 24  G   C "O3'" 1 
ATOM   6316 C  "C2'" . G   C 3 24  ? 142.620 138.785 106.828 1.00 1027.2 ? 24  G   C "C2'" 1 
ATOM   6317 O  "O2'" . G   C 3 24  ? 142.521 137.376 106.674 1.00 1027.2 ? 24  G   C "O2'" 1 
ATOM   6318 C  "C1'" . G   C 3 24  ? 143.387 139.076 108.117 1.00 1027.2 ? 24  G   C "C1'" 1 
ATOM   6319 N  N9    . G   C 3 24  ? 142.956 140.331 108.761 1.00 1027.2 ? 24  G   C N9    1 
ATOM   6320 C  C8    . G   C 3 24  ? 143.675 141.499 108.804 1.00 1027.2 ? 24  G   C C8    1 
ATOM   6321 N  N7    . G   C 3 24  ? 143.070 142.457 109.448 1.00 1027.2 ? 24  G   C N7    1 
ATOM   6322 C  C5    . G   C 3 24  ? 141.877 141.886 109.861 1.00 1027.2 ? 24  G   C C5    1 
ATOM   6323 C  C6    . G   C 3 24  ? 140.809 142.453 110.598 1.00 1027.2 ? 24  G   C C6    1 
ATOM   6324 O  O6    . G   C 3 24  ? 140.727 143.601 111.048 1.00 1027.2 ? 24  G   C O6    1 
ATOM   6325 N  N1    . G   C 3 24  ? 139.784 141.535 110.803 1.00 1027.2 ? 24  G   C N1    1 
ATOM   6326 C  C2    . G   C 3 24  ? 139.787 140.239 110.347 1.00 1027.2 ? 24  G   C C2    1 
ATOM   6327 N  N2    . G   C 3 24  ? 138.706 139.500 110.640 1.00 1027.2 ? 24  G   C N2    1 
ATOM   6328 N  N3    . G   C 3 24  ? 140.778 139.700 109.653 1.00 1027.2 ? 24  G   C N3    1 
ATOM   6329 C  C4    . G   C 3 24  ? 141.787 140.572 109.447 1.00 1027.2 ? 24  G   C C4    1 
ATOM   6330 P  P     . U   C 3 25  ? 142.392 139.550 103.432 1.00 1027.2 ? 25  U   C P     1 
ATOM   6331 O  OP1   . U   C 3 25  ? 142.577 138.896 102.112 1.00 1027.2 ? 25  U   C OP1   1 
ATOM   6332 O  OP2   . U   C 3 25  ? 142.585 141.017 103.558 1.00 1027.2 ? 25  U   C OP2   1 
ATOM   6333 O  "O5'" . U   C 3 25  ? 140.929 139.198 103.956 1.00 1027.2 ? 25  U   C "O5'" 1 
ATOM   6334 C  "C5'" . U   C 3 25  ? 140.468 137.856 103.998 1.00 1027.2 ? 25  U   C "C5'" 1 
ATOM   6335 C  "C4'" . U   C 3 25  ? 139.138 137.754 104.703 1.00 1027.2 ? 25  U   C "C4'" 1 
ATOM   6336 O  "O4'" . U   C 3 25  ? 139.288 138.165 106.086 1.00 1027.2 ? 25  U   C "O4'" 1 
ATOM   6337 C  "C3'" . U   C 3 25  ? 138.035 138.652 104.163 1.00 1027.2 ? 25  U   C "C3'" 1 
ATOM   6338 O  "O3'" . U   C 3 25  ? 137.378 138.093 103.037 1.00 1027.2 ? 25  U   C "O3'" 1 
ATOM   6339 C  "C2'" . U   C 3 25  ? 137.123 138.835 105.370 1.00 1027.2 ? 25  U   C "C2'" 1 
ATOM   6340 O  "O2'" . U   C 3 25  ? 136.277 137.707 105.535 1.00 1027.2 ? 25  U   C "O2'" 1 
ATOM   6341 C  "C1'" . U   C 3 25  ? 138.134 138.853 106.517 1.00 1027.2 ? 25  U   C "C1'" 1 
ATOM   6342 N  N1    . U   C 3 25  ? 138.528 140.224 106.913 1.00 1027.2 ? 25  U   C N1    1 
ATOM   6343 C  C2    . U   C 3 25  ? 137.669 140.965 107.704 1.00 1027.2 ? 25  U   C C2    1 
ATOM   6344 O  O2    . U   C 3 25  ? 136.587 140.547 108.081 1.00 1027.2 ? 25  U   C O2    1 
ATOM   6345 N  N3    . U   C 3 25  ? 138.120 142.221 108.034 1.00 1027.2 ? 25  U   C N3    1 
ATOM   6346 C  C4    . U   C 3 25  ? 139.322 142.794 107.662 1.00 1027.2 ? 25  U   C C4    1 
ATOM   6347 O  O4    . U   C 3 25  ? 139.608 143.934 108.029 1.00 1027.2 ? 25  U   C O4    1 
ATOM   6348 C  C5    . U   C 3 25  ? 140.155 141.962 106.853 1.00 1027.2 ? 25  U   C C5    1 
ATOM   6349 C  C6    . U   C 3 25  ? 139.739 140.739 106.519 1.00 1027.2 ? 25  U   C C6    1 
ATOM   6350 P  P     . A   C 3 26  ? 136.815 139.042 101.870 1.00 1027.2 ? 26  A   C P     1 
ATOM   6351 O  OP1   . A   C 3 26  ? 136.476 138.183 100.707 1.00 1027.2 ? 26  A   C OP1   1 
ATOM   6352 O  OP2   . A   C 3 26  ? 137.762 140.172 101.697 1.00 1027.2 ? 26  A   C OP2   1 
ATOM   6353 O  "O5'" . A   C 3 26  ? 135.455 139.623 102.465 1.00 1027.2 ? 26  A   C "O5'" 1 
ATOM   6354 C  "C5'" . A   C 3 26  ? 134.384 138.760 102.820 1.00 1027.2 ? 26  A   C "C5'" 1 
ATOM   6355 C  "C4'" . A   C 3 26  ? 133.398 139.452 103.728 1.00 1027.2 ? 26  A   C "C4'" 1 
ATOM   6356 O  "O4'" . A   C 3 26  ? 134.075 139.889 104.935 1.00 1027.2 ? 26  A   C "O4'" 1 
ATOM   6357 C  "C3'" . A   C 3 26  ? 132.764 140.720 103.176 1.00 1027.2 ? 26  A   C "C3'" 1 
ATOM   6358 O  "O3'" . A   C 3 26  ? 131.663 140.460 102.325 1.00 1027.2 ? 26  A   C "O3'" 1 
ATOM   6359 C  "C2'" . A   C 3 26  ? 132.391 141.486 104.439 1.00 1027.2 ? 26  A   C "C2'" 1 
ATOM   6360 O  "O2'" . A   C 3 26  ? 131.196 140.968 105.003 1.00 1027.2 ? 26  A   C "O2'" 1 
ATOM   6361 C  "C1'" . A   C 3 26  ? 133.553 141.129 105.362 1.00 1027.2 ? 26  A   C "C1'" 1 
ATOM   6362 N  N9    . A   C 3 26  ? 134.635 142.130 105.309 1.00 1027.2 ? 26  A   C N9    1 
ATOM   6363 C  C8    . A   C 3 26  ? 135.837 142.024 104.654 1.00 1027.2 ? 26  A   C C8    1 
ATOM   6364 N  N7    . A   C 3 26  ? 136.608 143.075 104.789 1.00 1027.2 ? 26  A   C N7    1 
ATOM   6365 C  C5    . A   C 3 26  ? 135.863 143.929 105.588 1.00 1027.2 ? 26  A   C C5    1 
ATOM   6366 C  C6    . A   C 3 26  ? 136.126 145.213 106.094 1.00 1027.2 ? 26  A   C C6    1 
ATOM   6367 N  N6    . A   C 3 26  ? 137.257 145.878 105.858 1.00 1027.2 ? 26  A   C N6    1 
ATOM   6368 N  N1    . A   C 3 26  ? 135.177 145.796 106.861 1.00 1027.2 ? 26  A   C N1    1 
ATOM   6369 C  C2    . A   C 3 26  ? 134.042 145.125 107.092 1.00 1027.2 ? 26  A   C C2    1 
ATOM   6370 N  N3    . A   C 3 26  ? 133.681 143.912 106.675 1.00 1027.2 ? 26  A   C N3    1 
ATOM   6371 C  C4    . A   C 3 26  ? 134.646 143.362 105.917 1.00 1027.2 ? 26  A   C C4    1 
ATOM   6372 P  P     . U   C 3 27  ? 131.310 141.467 101.123 1.00 1027.2 ? 27  U   C P     1 
ATOM   6373 O  OP1   . U   C 3 27  ? 130.223 140.855 100.317 1.00 1027.2 ? 27  U   C OP1   1 
ATOM   6374 O  OP2   . U   C 3 27  ? 132.582 141.858 100.463 1.00 1027.2 ? 27  U   C OP2   1 
ATOM   6375 O  "O5'" . U   C 3 27  ? 130.717 142.754 101.855 1.00 1027.2 ? 27  U   C "O5'" 1 
ATOM   6376 C  "C5'" . U   C 3 27  ? 129.528 142.673 102.627 1.00 1027.2 ? 27  U   C "C5'" 1 
ATOM   6377 C  "C4'" . U   C 3 27  ? 129.319 143.916 103.455 1.00 1027.2 ? 27  U   C "C4'" 1 
ATOM   6378 O  "O4'" . U   C 3 27  ? 130.458 144.120 104.332 1.00 1027.2 ? 27  U   C "O4'" 1 
ATOM   6379 C  "C3'" . U   C 3 27  ? 129.212 145.221 102.682 1.00 1027.2 ? 27  U   C "C3'" 1 
ATOM   6380 O  "O3'" . U   C 3 27  ? 127.921 145.438 102.139 1.00 1027.2 ? 27  U   C "O3'" 1 
ATOM   6381 C  "C2'" . U   C 3 27  ? 129.620 146.258 103.719 1.00 1027.2 ? 27  U   C "C2'" 1 
ATOM   6382 O  "O2'" . U   C 3 27  ? 128.546 146.532 104.606 1.00 1027.2 ? 27  U   C "O2'" 1 
ATOM   6383 C  "C1'" . U   C 3 27  ? 130.703 145.503 104.491 1.00 1027.2 ? 27  U   C "C1'" 1 
ATOM   6384 N  N1    . U   C 3 27  ? 132.064 145.805 103.989 1.00 1027.2 ? 27  U   C N1    1 
ATOM   6385 C  C2    . U   C 3 27  ? 132.660 146.985 104.396 1.00 1027.2 ? 27  U   C C2    1 
ATOM   6386 O  O2    . U   C 3 27  ? 132.114 147.779 105.143 1.00 1027.2 ? 27  U   C O2    1 
ATOM   6387 N  N3    . U   C 3 27  ? 133.922 147.205 103.897 1.00 1027.2 ? 27  U   C N3    1 
ATOM   6388 C  C4    . U   C 3 27  ? 134.631 146.378 103.049 1.00 1027.2 ? 27  U   C C4    1 
ATOM   6389 O  O4    . U   C 3 27  ? 135.761 146.697 102.675 1.00 1027.2 ? 27  U   C O4    1 
ATOM   6390 C  C5    . U   C 3 27  ? 133.947 145.177 102.676 1.00 1027.2 ? 27  U   C C5    1 
ATOM   6391 C  C6    . U   C 3 27  ? 132.720 144.938 103.147 1.00 1027.2 ? 27  U   C C6    1 
HETATM 6392 MG MG    . MG  D 4 .   ? 128.318 146.406 170.433 1.00 124.44 ? 701 MG  A MG    1 
HETATM 6393 P  PB    . ADP E 5 .   ? 124.947 147.937 172.418 1.00 167.23 ? 702 ADP A PB    1 
HETATM 6394 O  O1B   . ADP E 5 .   ? 126.335 148.529 172.410 1.00 167.23 ? 702 ADP A O1B   1 
HETATM 6395 O  O2B   . ADP E 5 .   ? 123.832 148.944 172.533 1.00 167.23 ? 702 ADP A O2B   1 
HETATM 6396 O  O3B   . ADP E 5 .   ? 124.715 146.896 171.351 1.00 167.23 ? 702 ADP A O3B   1 
HETATM 6397 P  PA    . ADP E 5 .   ? 125.395 147.682 175.207 1.00 167.23 ? 702 ADP A PA    1 
HETATM 6398 O  O1A   . ADP E 5 .   ? 126.904 147.676 175.213 1.00 167.23 ? 702 ADP A O1A   1 
HETATM 6399 O  O2A   . ADP E 5 .   ? 124.639 146.972 176.302 1.00 167.23 ? 702 ADP A O2A   1 
HETATM 6400 O  O3A   . ADP E 5 .   ? 124.896 147.094 173.790 1.00 167.23 ? 702 ADP A O3A   1 
HETATM 6401 O  "O5'" . ADP E 5 .   ? 124.904 149.215 175.247 1.00 167.23 ? 702 ADP A "O5'" 1 
HETATM 6402 C  "C5'" . ADP E 5 .   ? 123.548 149.527 175.560 1.00 167.23 ? 702 ADP A "C5'" 1 
HETATM 6403 C  "C4'" . ADP E 5 .   ? 123.497 150.409 176.799 1.00 167.23 ? 702 ADP A "C4'" 1 
HETATM 6404 O  "O4'" . ADP E 5 .   ? 122.162 150.864 177.032 1.00 167.23 ? 702 ADP A "O4'" 1 
HETATM 6405 C  "C3'" . ADP E 5 .   ? 123.926 149.630 178.032 1.00 167.23 ? 702 ADP A "C3'" 1 
HETATM 6406 O  "O3'" . ADP E 5 .   ? 125.135 150.180 178.560 1.00 167.23 ? 702 ADP A "O3'" 1 
HETATM 6407 C  "C2'" . ADP E 5 .   ? 122.805 149.789 179.038 1.00 167.23 ? 702 ADP A "C2'" 1 
HETATM 6408 O  "O2'" . ADP E 5 .   ? 123.322 150.293 180.271 1.00 167.23 ? 702 ADP A "O2'" 1 
HETATM 6409 C  "C1'" . ADP E 5 .   ? 121.843 150.793 178.424 1.00 167.23 ? 702 ADP A "C1'" 1 
HETATM 6410 N  N9    . ADP E 5 .   ? 120.436 150.351 178.603 1.00 167.23 ? 702 ADP A N9    1 
HETATM 6411 C  C8    . ADP E 5 .   ? 119.561 150.107 177.609 1.00 167.23 ? 702 ADP A C8    1 
HETATM 6412 N  N7    . ADP E 5 .   ? 118.354 149.729 178.099 1.00 167.23 ? 702 ADP A N7    1 
HETATM 6413 C  C5    . ADP E 5 .   ? 118.444 149.732 179.440 1.00 167.23 ? 702 ADP A C5    1 
HETATM 6414 C  C6    . ADP E 5 .   ? 117.533 149.434 180.570 1.00 167.23 ? 702 ADP A C6    1 
HETATM 6415 N  N6    . ADP E 5 .   ? 116.254 149.047 180.351 1.00 167.23 ? 702 ADP A N6    1 
HETATM 6416 N  N1    . ADP E 5 .   ? 118.022 149.561 181.823 1.00 167.23 ? 702 ADP A N1    1 
HETATM 6417 C  C2    . ADP E 5 .   ? 119.292 149.944 182.050 1.00 167.23 ? 702 ADP A C2    1 
HETATM 6418 N  N3    . ADP E 5 .   ? 120.172 150.232 181.074 1.00 167.23 ? 702 ADP A N3    1 
HETATM 6419 C  C4    . ADP E 5 .   ? 119.816 150.148 179.769 1.00 167.23 ? 702 ADP A C4    1 
# 
