data_9MTB
# 
_entry.id   9MTB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MTB         pdb_00009mtb 10.2210/pdb9mtb/pdb 
WWPDB D_1000291736 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-04 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MTB 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 9MT9 unspecified 
PDB . 9MT3 unspecified 
PDB . 9MSX unspecified 
PDB . 9MSV unspecified 
PDB . 9MSQ unspecified 
PDB . 9MSU unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              redinbo@unc.edu 
_pdbx_contact_author.name_first         Matthew 
_pdbx_contact_author.name_last          Redinbo 
_pdbx_contact_author.name_mi            R 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0814-5346 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kowalewski, M.E.' 1 0000-0001-9455-7333 
'Redinbo, M.R.'    2 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochemistry 
_citation.journal_id_ASTM           BICHAW 
_citation.journal_id_CSD            0033 
_citation.journal_id_ISSN           0006-2960 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            64 
_citation.language                  ? 
_citation.page_first                2401 
_citation.page_last                 2411 
_citation.title                     'Structural Insights into Selectively Targeting Candida albicans Hsp90.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.biochem.5c00015 
_citation.pdbx_database_id_PubMed   40397669 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kowalewski, M.E.' 1 ? 
primary 'Zagler, S.'       2 ? 
primary 'Redinbo, M.R.'    3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Heat shock protein 90 homolog'               26350.838 1  ? ? ? ? 
2 non-polymer syn 'PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER' 506.196   1  ? ? ? ? 
3 water       nat water                                         18.015    16 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER' ANP 
3 water                                         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   ASP n 
1 4   ALA n 
1 5   LYS n 
1 6   VAL n 
1 7   GLU n 
1 8   THR n 
1 9   HIS n 
1 10  GLU n 
1 11  PHE n 
1 12  THR n 
1 13  ALA n 
1 14  GLU n 
1 15  ILE n 
1 16  SER n 
1 17  GLN n 
1 18  LEU n 
1 19  MET n 
1 20  SER n 
1 21  LEU n 
1 22  ILE n 
1 23  ILE n 
1 24  ASN n 
1 25  THR n 
1 26  VAL n 
1 27  TYR n 
1 28  SER n 
1 29  ASN n 
1 30  LYS n 
1 31  GLU n 
1 32  ILE n 
1 33  PHE n 
1 34  LEU n 
1 35  ARG n 
1 36  GLU n 
1 37  LEU n 
1 38  ILE n 
1 39  SER n 
1 40  ASN n 
1 41  ALA n 
1 42  SER n 
1 43  ASP n 
1 44  ALA n 
1 45  LEU n 
1 46  ASP n 
1 47  LYS n 
1 48  ILE n 
1 49  ARG n 
1 50  TYR n 
1 51  GLN n 
1 52  ALA n 
1 53  LEU n 
1 54  SER n 
1 55  ASP n 
1 56  PRO n 
1 57  SER n 
1 58  GLN n 
1 59  LEU n 
1 60  GLU n 
1 61  SER n 
1 62  GLU n 
1 63  PRO n 
1 64  GLU n 
1 65  LEU n 
1 66  PHE n 
1 67  ILE n 
1 68  ARG n 
1 69  ILE n 
1 70  ILE n 
1 71  PRO n 
1 72  GLN n 
1 73  LYS n 
1 74  ASP n 
1 75  GLN n 
1 76  LYS n 
1 77  VAL n 
1 78  LEU n 
1 79  GLU n 
1 80  ILE n 
1 81  ARG n 
1 82  ASP n 
1 83  SER n 
1 84  GLY n 
1 85  ILE n 
1 86  GLY n 
1 87  MET n 
1 88  THR n 
1 89  LYS n 
1 90  ALA n 
1 91  ASP n 
1 92  LEU n 
1 93  VAL n 
1 94  ASN n 
1 95  ASN n 
1 96  LEU n 
1 97  GLY n 
1 98  THR n 
1 99  ILE n 
1 100 ALA n 
1 101 LYS n 
1 102 SER n 
1 103 GLY n 
1 104 THR n 
1 105 LYS n 
1 106 SER n 
1 107 PHE n 
1 108 MET n 
1 109 GLU n 
1 110 ALA n 
1 111 LEU n 
1 112 SER n 
1 113 ALA n 
1 114 GLY n 
1 115 ALA n 
1 116 ASP n 
1 117 VAL n 
1 118 SER n 
1 119 MET n 
1 120 ILE n 
1 121 GLY n 
1 122 GLN n 
1 123 PHE n 
1 124 GLY n 
1 125 VAL n 
1 126 GLY n 
1 127 PHE n 
1 128 TYR n 
1 129 SER n 
1 130 LEU n 
1 131 PHE n 
1 132 LEU n 
1 133 VAL n 
1 134 ALA n 
1 135 ASP n 
1 136 HIS n 
1 137 VAL n 
1 138 GLN n 
1 139 VAL n 
1 140 ILE n 
1 141 SER n 
1 142 LYS n 
1 143 HIS n 
1 144 ASN n 
1 145 ASP n 
1 146 ASP n 
1 147 GLU n 
1 148 GLN n 
1 149 TYR n 
1 150 VAL n 
1 151 TRP n 
1 152 GLU n 
1 153 SER n 
1 154 ASN n 
1 155 ALA n 
1 156 GLY n 
1 157 GLY n 
1 158 LYS n 
1 159 PHE n 
1 160 THR n 
1 161 VAL n 
1 162 THR n 
1 163 LEU n 
1 164 ASP n 
1 165 GLU n 
1 166 THR n 
1 167 ASN n 
1 168 GLU n 
1 169 ARG n 
1 170 LEU n 
1 171 GLY n 
1 172 ARG n 
1 173 GLY n 
1 174 THR n 
1 175 MET n 
1 176 LEU n 
1 177 ARG n 
1 178 LEU n 
1 179 PHE n 
1 180 LEU n 
1 181 LYS n 
1 182 GLU n 
1 183 ASP n 
1 184 GLN n 
1 185 LEU n 
1 186 GLU n 
1 187 TYR n 
1 188 LEU n 
1 189 GLU n 
1 190 GLU n 
1 191 LYS n 
1 192 ARG n 
1 193 ILE n 
1 194 LYS n 
1 195 GLU n 
1 196 VAL n 
1 197 VAL n 
1 198 LYS n 
1 199 LYS n 
1 200 HIS n 
1 201 SER n 
1 202 GLU n 
1 203 PHE n 
1 204 VAL n 
1 205 ALA n 
1 206 TYR n 
1 207 PRO n 
1 208 ILE n 
1 209 GLN n 
1 210 LEU n 
1 211 VAL n 
1 212 VAL n 
1 213 THR n 
1 214 LYS n 
1 215 GLU n 
1 216 VAL n 
1 217 GLU n 
1 218 LYS n 
1 219 ASN n 
1 220 LEU n 
1 221 TYR n 
1 222 PHE n 
1 223 GLN n 
1 224 SER n 
1 225 GLY n 
1 226 SER n 
1 227 HIS n 
1 228 HIS n 
1 229 HIS n 
1 230 HIS n 
1 231 HIS n 
1 232 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   232 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'HSP90, CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Candida albicans' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5476 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                       ? 'C3 H7 N O2'        89.093  
ANP non-polymer         . 'PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER' ? 'C10 H17 N6 O12 P3' 506.196 
ARG 'L-peptide linking' y ARGININE                                      ? 'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                                    ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                               ? 'C4 H7 N O4'        133.103 
GLN 'L-peptide linking' y GLUTAMINE                                     ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                               ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                                       ? 'C2 H5 N O2'        75.067  
HIS 'L-peptide linking' y HISTIDINE                                     ? 'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                                         ? 'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                    ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                                       ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                                        ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                                    ? 'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                 ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                                       ? 'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                                        ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                                     ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                    ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                                      ? 'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                                        ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   ASP 3   3   ?   ?   ?   A . n 
A 1 4   ALA 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   THR 8   8   8   THR THR A . n 
A 1 9   HIS 9   9   9   HIS HIS A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  ALA 13  13  13  ALA ALA A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  SER 16  16  16  SER SER A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  MET 19  19  19  MET MET A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  ILE 22  22  22  ILE ILE A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  ASN 24  24  24  ASN ASN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  VAL 26  26  26  VAL VAL A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  PHE 33  33  33  PHE PHE A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  GLU 36  36  36  GLU GLU A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  ASP 43  43  43  ASP ASP A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  ASP 46  46  46  ASP ASP A . n 
A 1 47  LYS 47  47  47  LYS LYS A . n 
A 1 48  ILE 48  48  48  ILE ILE A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  TYR 50  50  50  TYR TYR A . n 
A 1 51  GLN 51  51  51  GLN GLN A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  PRO 56  56  56  PRO PRO A . n 
A 1 57  SER 57  57  57  SER SER A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  GLU 60  60  60  GLU GLU A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  ILE 67  67  67  ILE ILE A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  ILE 69  69  69  ILE ILE A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  GLU 79  79  79  GLU GLU A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ARG 81  81  81  ARG ARG A . n 
A 1 82  ASP 82  82  82  ASP ASP A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  MET 87  87  87  MET MET A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLY 97  97  97  GLY GLY A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 ALA 100 100 100 ALA ALA A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 LYS 105 105 105 LYS LYS A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 MET 108 108 108 MET MET A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 MET 119 119 119 MET MET A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLN 122 122 122 GLN GLN A . n 
A 1 123 PHE 123 123 123 PHE PHE A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 PHE 127 127 127 PHE PHE A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 PHE 131 131 131 PHE PHE A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 HIS 136 136 136 HIS HIS A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 SER 141 141 141 SER SER A . n 
A 1 142 LYS 142 142 142 LYS LYS A . n 
A 1 143 HIS 143 143 143 HIS HIS A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 GLU 147 147 147 GLU GLU A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 TRP 151 151 151 TRP TRP A . n 
A 1 152 GLU 152 152 152 GLU GLU A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 GLY 156 156 156 GLY GLY A . n 
A 1 157 GLY 157 157 157 GLY GLY A . n 
A 1 158 LYS 158 158 158 LYS LYS A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLU 165 165 165 GLU GLU A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 ASN 167 167 167 ASN ASN A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLY 171 171 171 GLY GLY A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 MET 175 175 175 MET MET A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 PHE 179 179 179 PHE PHE A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 LYS 181 181 181 LYS LYS A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 GLN 184 184 184 GLN GLN A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 GLU 186 186 186 GLU GLU A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 LYS 194 194 194 LYS LYS A . n 
A 1 195 GLU 195 195 195 GLU GLU A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 LYS 198 198 198 LYS LYS A . n 
A 1 199 LYS 199 199 199 LYS LYS A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 GLU 202 202 202 GLU GLU A . n 
A 1 203 PHE 203 203 203 PHE PHE A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 PRO 207 207 207 PRO PRO A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 GLN 209 209 209 GLN GLN A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 GLU 215 215 215 GLU GLU A . n 
A 1 216 VAL 216 216 216 VAL VAL A . n 
A 1 217 GLU 217 217 217 GLU GLU A . n 
A 1 218 LYS 218 218 ?   ?   ?   A . n 
A 1 219 ASN 219 219 ?   ?   ?   A . n 
A 1 220 LEU 220 220 ?   ?   ?   A . n 
A 1 221 TYR 221 221 ?   ?   ?   A . n 
A 1 222 PHE 222 222 ?   ?   ?   A . n 
A 1 223 GLN 223 223 ?   ?   ?   A . n 
A 1 224 SER 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 SER 226 226 ?   ?   ?   A . n 
A 1 227 HIS 227 227 ?   ?   ?   A . n 
A 1 228 HIS 228 228 ?   ?   ?   A . n 
A 1 229 HIS 229 229 ?   ?   ?   A . n 
A 1 230 HIS 230 230 ?   ?   ?   A . n 
A 1 231 HIS 231 231 ?   ?   ?   A . n 
A 1 232 HIS 232 232 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ANP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ANP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ANP 1  301 301 ANP ANP A . 
C 3 HOH 1  401 11  HOH HOH A . 
C 3 HOH 2  402 14  HOH HOH A . 
C 3 HOH 3  403 6   HOH HOH A . 
C 3 HOH 4  404 18  HOH HOH A . 
C 3 HOH 5  405 1   HOH HOH A . 
C 3 HOH 6  406 7   HOH HOH A . 
C 3 HOH 7  407 13  HOH HOH A . 
C 3 HOH 8  408 4   HOH HOH A . 
C 3 HOH 9  409 9   HOH HOH A . 
C 3 HOH 10 410 2   HOH HOH A . 
C 3 HOH 11 411 8   HOH HOH A . 
C 3 HOH 12 412 10  HOH HOH A . 
C 3 HOH 13 413 19  HOH HOH A . 
C 3 HOH 14 414 15  HOH HOH A . 
C 3 HOH 15 415 3   HOH HOH A . 
C 3 HOH 16 416 12  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 5   ? CG  ? A LYS 5   CG  
2  1 Y 1 A LYS 5   ? CD  ? A LYS 5   CD  
3  1 Y 1 A LYS 5   ? CE  ? A LYS 5   CE  
4  1 Y 1 A LYS 5   ? NZ  ? A LYS 5   NZ  
5  1 Y 1 A VAL 6   ? CG1 ? A VAL 6   CG1 
6  1 Y 1 A VAL 6   ? CG2 ? A VAL 6   CG2 
7  1 Y 1 A GLN 17  ? CG  ? A GLN 17  CG  
8  1 Y 1 A GLN 17  ? CD  ? A GLN 17  CD  
9  1 Y 1 A GLN 17  ? OE1 ? A GLN 17  OE1 
10 1 Y 1 A GLN 17  ? NE2 ? A GLN 17  NE2 
11 1 Y 1 A ILE 99  ? CG1 ? A ILE 99  CG1 
12 1 Y 1 A ILE 99  ? CG2 ? A ILE 99  CG2 
13 1 Y 1 A ILE 99  ? CD1 ? A ILE 99  CD1 
14 1 Y 1 A LYS 101 ? CG  ? A LYS 101 CG  
15 1 Y 1 A LYS 101 ? CD  ? A LYS 101 CD  
16 1 Y 1 A LYS 101 ? CE  ? A LYS 101 CE  
17 1 Y 1 A LYS 101 ? NZ  ? A LYS 101 NZ  
18 1 Y 1 A LYS 105 ? CG  ? A LYS 105 CG  
19 1 Y 1 A LYS 105 ? CD  ? A LYS 105 CD  
20 1 Y 1 A LYS 105 ? CE  ? A LYS 105 CE  
21 1 Y 1 A LYS 105 ? NZ  ? A LYS 105 NZ  
22 1 Y 1 A LYS 158 ? CG  ? A LYS 158 CG  
23 1 Y 1 A LYS 158 ? CD  ? A LYS 158 CD  
24 1 Y 1 A LYS 158 ? CE  ? A LYS 158 CE  
25 1 Y 1 A LYS 158 ? NZ  ? A LYS 158 NZ  
26 1 Y 1 A GLU 202 ? CG  ? A GLU 202 CG  
27 1 Y 1 A GLU 202 ? CD  ? A GLU 202 CD  
28 1 Y 1 A GLU 202 ? OE1 ? A GLU 202 OE1 
29 1 Y 1 A GLU 202 ? OE2 ? A GLU 202 OE2 
30 1 Y 1 A LYS 214 ? CG  ? A LYS 214 CG  
31 1 Y 1 A LYS 214 ? CD  ? A LYS 214 CD  
32 1 Y 1 A LYS 214 ? CE  ? A LYS 214 CE  
33 1 Y 1 A LYS 214 ? NZ  ? A LYS 214 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.21.1_5286 1 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MTB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.162 
_cell.length_a_esd                 ? 
_cell.length_b                     74.162 
_cell.length_b_esd                 ? 
_cell.length_c                     107.610 
_cell.length_c_esd                 ? 
_cell.volume                       591855.241 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MTB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                95 
_symmetry.space_group_name_Hall            'P 4cw 2c' 
_symmetry.space_group_name_H-M             'P 43 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MTB 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.81 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.19 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.17 M ammonium acetate, 0.085 M sodium citrate:HCl pH 5.6, 25.5% w/v PEG4000, and 15% glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          47.67 
_reflns.entry_id                                       9MTB 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.53 
_reflns.d_resolution_low                               31.7 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10547 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.88 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                14.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.68 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1054 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.53 
_reflns_shell.d_res_low                                     2.64 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.63 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1286 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               15 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.934 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.64 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.5638 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.62 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MTB 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.53 
_refine.ls_d_res_low                             31.70 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10547 
_refine.ls_number_reflns_R_free                  1055 
_refine.ls_number_reflns_R_work                  9492 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.80 
_refine.ls_percent_reflns_R_free                 10.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2121 
_refine.ls_R_factor_R_free                       0.2693 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2058 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.5324 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3088 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.53 
_refine_hist.d_res_low                        31.70 
_refine_hist.number_atoms_solvent             16 
_refine_hist.number_atoms_total               1708 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1661 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         31 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0142  ? 1719 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4944  ? 2331 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0666  ? 269  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0115  ? 296  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 17.7410 ? 651  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.53 2.65  . . 129 1158 99.54  . . . . 0.2513 . . . . . . . . . . . 0.3071 
'X-RAY DIFFRACTION' 2.65 2.78  . . 128 1156 99.61  . . . . 0.2305 . . . . . . . . . . . 0.2796 
'X-RAY DIFFRACTION' 2.79 2.96  . . 129 1158 99.77  . . . . 0.2167 . . . . . . . . . . . 0.2482 
'X-RAY DIFFRACTION' 2.96 3.19  . . 129 1166 99.69  . . . . 0.2443 . . . . . . . . . . . 0.3171 
'X-RAY DIFFRACTION' 3.19 3.51  . . 129 1162 99.85  . . . . 0.2179 . . . . . . . . . . . 0.2781 
'X-RAY DIFFRACTION' 3.51 4.01  . . 132 1182 99.92  . . . . 0.1999 . . . . . . . . . . . 0.2973 
'X-RAY DIFFRACTION' 4.01 5.05  . . 135 1217 100.00 . . . . 0.1718 . . . . . . . . . . . 0.2016 
'X-RAY DIFFRACTION' 5.06 31.70 . . 144 1293 100.00 . . . . 0.2059 . . . . . . . . . . . 0.2953 
# 
_struct.entry_id                     9MTB 
_struct.title                        'Candida albicans Hsp90 nucleotide binding domain in complex with AMPPNP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MTB 
_struct_keywords.text            'Inhibitor complex, CHAPERONE, CHAPERONE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   CHAPERONE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HSP90_CANAL 
_struct_ref.pdbx_db_accession          P46598 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEK
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MTB 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 218 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P46598 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  218 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       218 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MTB ASN A 219 ? UNP P46598 ? ? 'expression tag' 219 1  
1 9MTB LEU A 220 ? UNP P46598 ? ? 'expression tag' 220 2  
1 9MTB TYR A 221 ? UNP P46598 ? ? 'expression tag' 221 3  
1 9MTB PHE A 222 ? UNP P46598 ? ? 'expression tag' 222 4  
1 9MTB GLN A 223 ? UNP P46598 ? ? 'expression tag' 223 5  
1 9MTB SER A 224 ? UNP P46598 ? ? 'expression tag' 224 6  
1 9MTB GLY A 225 ? UNP P46598 ? ? 'expression tag' 225 7  
1 9MTB SER A 226 ? UNP P46598 ? ? 'expression tag' 226 8  
1 9MTB HIS A 227 ? UNP P46598 ? ? 'expression tag' 227 9  
1 9MTB HIS A 228 ? UNP P46598 ? ? 'expression tag' 228 10 
1 9MTB HIS A 229 ? UNP P46598 ? ? 'expression tag' 229 11 
1 9MTB HIS A 230 ? UNP P46598 ? ? 'expression tag' 230 12 
1 9MTB HIS A 231 ? UNP P46598 ? ? 'expression tag' 231 13 
1 9MTB HIS A 232 ? UNP P46598 ? ? 'expression tag' 232 14 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 12  ? THR A 25  ? THR A 12  THR A 25  1 ? 14 
HELX_P HELX_P2  AA2 GLU A 31  ? ASP A 55  ? GLU A 31  ASP A 55  1 ? 25 
HELX_P HELX_P3  AA3 PRO A 56  ? GLU A 62  ? PRO A 56  GLU A 62  5 ? 7  
HELX_P HELX_P4  AA4 LYS A 73  ? GLN A 75  ? LYS A 73  GLN A 75  5 ? 3  
HELX_P HELX_P5  AA5 THR A 88  ? LEU A 96  ? THR A 88  LEU A 96  1 ? 9  
HELX_P HELX_P6  AA6 ALA A 100 ? ALA A 113 ? ALA A 100 ALA A 113 1 ? 14 
HELX_P HELX_P7  AA7 ASP A 116 ? GLY A 124 ? ASP A 116 GLY A 124 5 ? 9  
HELX_P HELX_P8  AA8 VAL A 125 ? LEU A 132 ? VAL A 125 LEU A 132 5 ? 8  
HELX_P HELX_P9  AA9 GLN A 184 ? LEU A 188 ? GLN A 184 LEU A 188 5 ? 5  
HELX_P HELX_P10 AB1 GLU A 189 ? SER A 201 ? GLU A 189 SER A 201 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   8 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 7   ? GLU A 10  ? GLU A 7   GLU A 10  
AA1 2 LYS A 158 ? LEU A 163 ? LYS A 158 LEU A 163 
AA1 3 TYR A 149 ? SER A 153 ? TYR A 149 SER A 153 
AA1 4 ALA A 134 ? LYS A 142 ? ALA A 134 LYS A 142 
AA1 5 GLY A 173 ? LEU A 180 ? GLY A 173 LEU A 180 
AA1 6 VAL A 77  ? ASP A 82  ? VAL A 77  ASP A 82  
AA1 7 ILE A 67  ? GLN A 72  ? ILE A 67  GLN A 72  
AA1 8 ILE A 208 ? LEU A 210 ? ILE A 208 LEU A 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 7   ? N GLU A 7   O VAL A 161 ? O VAL A 161 
AA1 2 3 O THR A 162 ? O THR A 162 N VAL A 150 ? N VAL A 150 
AA1 3 4 O TRP A 151 ? O TRP A 151 N VAL A 139 ? N VAL A 139 
AA1 4 5 N GLN A 138 ? N GLN A 138 O ARG A 177 ? O ARG A 177 
AA1 5 6 O LEU A 178 ? O LEU A 178 N LEU A 78  ? N LEU A 78  
AA1 6 7 O ARG A 81  ? O ARG A 81  N ARG A 68  ? N ARG A 68  
AA1 7 8 N ILE A 67  ? N ILE A 67  O GLN A 209 ? O GLN A 209 
# 
_pdbx_entry_details.entry_id                   9MTB 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 146 ? ? H A GLU 147 ? ? 1.57 
2 1 O   A ALA 115 ? ? O A HOH 401 ? ? 2.13 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 29  ? ? -95.12  59.25   
2 1 GLU A 62  ? ? -167.07 86.24   
3 1 SER A 83  ? ? -100.04 43.55   
4 1 ILE A 99  ? ? 174.38  -169.38 
5 1 ARG A 172 ? ? -174.99 124.47  
6 1 PHE A 203 ? ? -115.87 75.76   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z        
2 -y,x,z+3/4   
3 y,-x,z+1/4   
4 x,-y,-z+1/2  
5 -x,y,-z      
6 -x,-y,z+1/2  
7 y,x,-z+1/4   
8 -y,-x,-z+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ASP 3   ? A ASP 3   
4  1 Y 1 A ALA 4   ? A ALA 4   
5  1 Y 1 A LYS 218 ? A LYS 218 
6  1 Y 1 A ASN 219 ? A ASN 219 
7  1 Y 1 A LEU 220 ? A LEU 220 
8  1 Y 1 A TYR 221 ? A TYR 221 
9  1 Y 1 A PHE 222 ? A PHE 222 
10 1 Y 1 A GLN 223 ? A GLN 223 
11 1 Y 1 A SER 224 ? A SER 224 
12 1 Y 1 A GLY 225 ? A GLY 225 
13 1 Y 1 A SER 226 ? A SER 226 
14 1 Y 1 A HIS 227 ? A HIS 227 
15 1 Y 1 A HIS 228 ? A HIS 228 
16 1 Y 1 A HIS 229 ? A HIS 229 
17 1 Y 1 A HIS 230 ? A HIS 230 
18 1 Y 1 A HIS 231 ? A HIS 231 
19 1 Y 1 A HIS 232 ? A HIS 232 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ANP PG     P N N 14  
ANP O1G    O N N 15  
ANP O2G    O N N 16  
ANP O3G    O N N 17  
ANP PB     P N N 18  
ANP O1B    O N N 19  
ANP O2B    O N N 20  
ANP N3B    N N N 21  
ANP PA     P N N 22  
ANP O1A    O N N 23  
ANP O2A    O N N 24  
ANP O3A    O N N 25  
ANP "O5'"  O N N 26  
ANP "C5'"  C N N 27  
ANP "C4'"  C N R 28  
ANP "O4'"  O N N 29  
ANP "C3'"  C N S 30  
ANP "O3'"  O N N 31  
ANP "C2'"  C N R 32  
ANP "O2'"  O N N 33  
ANP "C1'"  C N R 34  
ANP N9     N Y N 35  
ANP C8     C Y N 36  
ANP N7     N Y N 37  
ANP C5     C Y N 38  
ANP C6     C Y N 39  
ANP N6     N N N 40  
ANP N1     N Y N 41  
ANP C2     C Y N 42  
ANP N3     N Y N 43  
ANP C4     C Y N 44  
ANP HOG2   H N N 45  
ANP HOG3   H N N 46  
ANP HOB2   H N N 47  
ANP HNB1   H N N 48  
ANP HOA2   H N N 49  
ANP "H5'1" H N N 50  
ANP "H5'2" H N N 51  
ANP "H4'"  H N N 52  
ANP "H3'"  H N N 53  
ANP "HO3'" H N N 54  
ANP "H2'"  H N N 55  
ANP "HO2'" H N N 56  
ANP "H1'"  H N N 57  
ANP H8     H N N 58  
ANP HN61   H N N 59  
ANP HN62   H N N 60  
ANP H2     H N N 61  
ARG N      N N N 62  
ARG CA     C N S 63  
ARG C      C N N 64  
ARG O      O N N 65  
ARG CB     C N N 66  
ARG CG     C N N 67  
ARG CD     C N N 68  
ARG NE     N N N 69  
ARG CZ     C N N 70  
ARG NH1    N N N 71  
ARG NH2    N N N 72  
ARG OXT    O N N 73  
ARG H      H N N 74  
ARG H2     H N N 75  
ARG HA     H N N 76  
ARG HB2    H N N 77  
ARG HB3    H N N 78  
ARG HG2    H N N 79  
ARG HG3    H N N 80  
ARG HD2    H N N 81  
ARG HD3    H N N 82  
ARG HE     H N N 83  
ARG HH11   H N N 84  
ARG HH12   H N N 85  
ARG HH21   H N N 86  
ARG HH22   H N N 87  
ARG HXT    H N N 88  
ASN N      N N N 89  
ASN CA     C N S 90  
ASN C      C N N 91  
ASN O      O N N 92  
ASN CB     C N N 93  
ASN CG     C N N 94  
ASN OD1    O N N 95  
ASN ND2    N N N 96  
ASN OXT    O N N 97  
ASN H      H N N 98  
ASN H2     H N N 99  
ASN HA     H N N 100 
ASN HB2    H N N 101 
ASN HB3    H N N 102 
ASN HD21   H N N 103 
ASN HD22   H N N 104 
ASN HXT    H N N 105 
ASP N      N N N 106 
ASP CA     C N S 107 
ASP C      C N N 108 
ASP O      O N N 109 
ASP CB     C N N 110 
ASP CG     C N N 111 
ASP OD1    O N N 112 
ASP OD2    O N N 113 
ASP OXT    O N N 114 
ASP H      H N N 115 
ASP H2     H N N 116 
ASP HA     H N N 117 
ASP HB2    H N N 118 
ASP HB3    H N N 119 
ASP HD2    H N N 120 
ASP HXT    H N N 121 
GLN N      N N N 122 
GLN CA     C N S 123 
GLN C      C N N 124 
GLN O      O N N 125 
GLN CB     C N N 126 
GLN CG     C N N 127 
GLN CD     C N N 128 
GLN OE1    O N N 129 
GLN NE2    N N N 130 
GLN OXT    O N N 131 
GLN H      H N N 132 
GLN H2     H N N 133 
GLN HA     H N N 134 
GLN HB2    H N N 135 
GLN HB3    H N N 136 
GLN HG2    H N N 137 
GLN HG3    H N N 138 
GLN HE21   H N N 139 
GLN HE22   H N N 140 
GLN HXT    H N N 141 
GLU N      N N N 142 
GLU CA     C N S 143 
GLU C      C N N 144 
GLU O      O N N 145 
GLU CB     C N N 146 
GLU CG     C N N 147 
GLU CD     C N N 148 
GLU OE1    O N N 149 
GLU OE2    O N N 150 
GLU OXT    O N N 151 
GLU H      H N N 152 
GLU H2     H N N 153 
GLU HA     H N N 154 
GLU HB2    H N N 155 
GLU HB3    H N N 156 
GLU HG2    H N N 157 
GLU HG3    H N N 158 
GLU HE2    H N N 159 
GLU HXT    H N N 160 
GLY N      N N N 161 
GLY CA     C N N 162 
GLY C      C N N 163 
GLY O      O N N 164 
GLY OXT    O N N 165 
GLY H      H N N 166 
GLY H2     H N N 167 
GLY HA2    H N N 168 
GLY HA3    H N N 169 
GLY HXT    H N N 170 
HIS N      N N N 171 
HIS CA     C N S 172 
HIS C      C N N 173 
HIS O      O N N 174 
HIS CB     C N N 175 
HIS CG     C Y N 176 
HIS ND1    N Y N 177 
HIS CD2    C Y N 178 
HIS CE1    C Y N 179 
HIS NE2    N Y N 180 
HIS OXT    O N N 181 
HIS H      H N N 182 
HIS H2     H N N 183 
HIS HA     H N N 184 
HIS HB2    H N N 185 
HIS HB3    H N N 186 
HIS HD1    H N N 187 
HIS HD2    H N N 188 
HIS HE1    H N N 189 
HIS HE2    H N N 190 
HIS HXT    H N N 191 
HOH O      O N N 192 
HOH H1     H N N 193 
HOH H2     H N N 194 
ILE N      N N N 195 
ILE CA     C N S 196 
ILE C      C N N 197 
ILE O      O N N 198 
ILE CB     C N S 199 
ILE CG1    C N N 200 
ILE CG2    C N N 201 
ILE CD1    C N N 202 
ILE OXT    O N N 203 
ILE H      H N N 204 
ILE H2     H N N 205 
ILE HA     H N N 206 
ILE HB     H N N 207 
ILE HG12   H N N 208 
ILE HG13   H N N 209 
ILE HG21   H N N 210 
ILE HG22   H N N 211 
ILE HG23   H N N 212 
ILE HD11   H N N 213 
ILE HD12   H N N 214 
ILE HD13   H N N 215 
ILE HXT    H N N 216 
LEU N      N N N 217 
LEU CA     C N S 218 
LEU C      C N N 219 
LEU O      O N N 220 
LEU CB     C N N 221 
LEU CG     C N N 222 
LEU CD1    C N N 223 
LEU CD2    C N N 224 
LEU OXT    O N N 225 
LEU H      H N N 226 
LEU H2     H N N 227 
LEU HA     H N N 228 
LEU HB2    H N N 229 
LEU HB3    H N N 230 
LEU HG     H N N 231 
LEU HD11   H N N 232 
LEU HD12   H N N 233 
LEU HD13   H N N 234 
LEU HD21   H N N 235 
LEU HD22   H N N 236 
LEU HD23   H N N 237 
LEU HXT    H N N 238 
LYS N      N N N 239 
LYS CA     C N S 240 
LYS C      C N N 241 
LYS O      O N N 242 
LYS CB     C N N 243 
LYS CG     C N N 244 
LYS CD     C N N 245 
LYS CE     C N N 246 
LYS NZ     N N N 247 
LYS OXT    O N N 248 
LYS H      H N N 249 
LYS H2     H N N 250 
LYS HA     H N N 251 
LYS HB2    H N N 252 
LYS HB3    H N N 253 
LYS HG2    H N N 254 
LYS HG3    H N N 255 
LYS HD2    H N N 256 
LYS HD3    H N N 257 
LYS HE2    H N N 258 
LYS HE3    H N N 259 
LYS HZ1    H N N 260 
LYS HZ2    H N N 261 
LYS HZ3    H N N 262 
LYS HXT    H N N 263 
MET N      N N N 264 
MET CA     C N S 265 
MET C      C N N 266 
MET O      O N N 267 
MET CB     C N N 268 
MET CG     C N N 269 
MET SD     S N N 270 
MET CE     C N N 271 
MET OXT    O N N 272 
MET H      H N N 273 
MET H2     H N N 274 
MET HA     H N N 275 
MET HB2    H N N 276 
MET HB3    H N N 277 
MET HG2    H N N 278 
MET HG3    H N N 279 
MET HE1    H N N 280 
MET HE2    H N N 281 
MET HE3    H N N 282 
MET HXT    H N N 283 
PHE N      N N N 284 
PHE CA     C N S 285 
PHE C      C N N 286 
PHE O      O N N 287 
PHE CB     C N N 288 
PHE CG     C Y N 289 
PHE CD1    C Y N 290 
PHE CD2    C Y N 291 
PHE CE1    C Y N 292 
PHE CE2    C Y N 293 
PHE CZ     C Y N 294 
PHE OXT    O N N 295 
PHE H      H N N 296 
PHE H2     H N N 297 
PHE HA     H N N 298 
PHE HB2    H N N 299 
PHE HB3    H N N 300 
PHE HD1    H N N 301 
PHE HD2    H N N 302 
PHE HE1    H N N 303 
PHE HE2    H N N 304 
PHE HZ     H N N 305 
PHE HXT    H N N 306 
PRO N      N N N 307 
PRO CA     C N S 308 
PRO C      C N N 309 
PRO O      O N N 310 
PRO CB     C N N 311 
PRO CG     C N N 312 
PRO CD     C N N 313 
PRO OXT    O N N 314 
PRO H      H N N 315 
PRO HA     H N N 316 
PRO HB2    H N N 317 
PRO HB3    H N N 318 
PRO HG2    H N N 319 
PRO HG3    H N N 320 
PRO HD2    H N N 321 
PRO HD3    H N N 322 
PRO HXT    H N N 323 
SER N      N N N 324 
SER CA     C N S 325 
SER C      C N N 326 
SER O      O N N 327 
SER CB     C N N 328 
SER OG     O N N 329 
SER OXT    O N N 330 
SER H      H N N 331 
SER H2     H N N 332 
SER HA     H N N 333 
SER HB2    H N N 334 
SER HB3    H N N 335 
SER HG     H N N 336 
SER HXT    H N N 337 
THR N      N N N 338 
THR CA     C N S 339 
THR C      C N N 340 
THR O      O N N 341 
THR CB     C N R 342 
THR OG1    O N N 343 
THR CG2    C N N 344 
THR OXT    O N N 345 
THR H      H N N 346 
THR H2     H N N 347 
THR HA     H N N 348 
THR HB     H N N 349 
THR HG1    H N N 350 
THR HG21   H N N 351 
THR HG22   H N N 352 
THR HG23   H N N 353 
THR HXT    H N N 354 
TRP N      N N N 355 
TRP CA     C N S 356 
TRP C      C N N 357 
TRP O      O N N 358 
TRP CB     C N N 359 
TRP CG     C Y N 360 
TRP CD1    C Y N 361 
TRP CD2    C Y N 362 
TRP NE1    N Y N 363 
TRP CE2    C Y N 364 
TRP CE3    C Y N 365 
TRP CZ2    C Y N 366 
TRP CZ3    C Y N 367 
TRP CH2    C Y N 368 
TRP OXT    O N N 369 
TRP H      H N N 370 
TRP H2     H N N 371 
TRP HA     H N N 372 
TRP HB2    H N N 373 
TRP HB3    H N N 374 
TRP HD1    H N N 375 
TRP HE1    H N N 376 
TRP HE3    H N N 377 
TRP HZ2    H N N 378 
TRP HZ3    H N N 379 
TRP HH2    H N N 380 
TRP HXT    H N N 381 
TYR N      N N N 382 
TYR CA     C N S 383 
TYR C      C N N 384 
TYR O      O N N 385 
TYR CB     C N N 386 
TYR CG     C Y N 387 
TYR CD1    C Y N 388 
TYR CD2    C Y N 389 
TYR CE1    C Y N 390 
TYR CE2    C Y N 391 
TYR CZ     C Y N 392 
TYR OH     O N N 393 
TYR OXT    O N N 394 
TYR H      H N N 395 
TYR H2     H N N 396 
TYR HA     H N N 397 
TYR HB2    H N N 398 
TYR HB3    H N N 399 
TYR HD1    H N N 400 
TYR HD2    H N N 401 
TYR HE1    H N N 402 
TYR HE2    H N N 403 
TYR HH     H N N 404 
TYR HXT    H N N 405 
VAL N      N N N 406 
VAL CA     C N S 407 
VAL C      C N N 408 
VAL O      O N N 409 
VAL CB     C N N 410 
VAL CG1    C N N 411 
VAL CG2    C N N 412 
VAL OXT    O N N 413 
VAL H      H N N 414 
VAL H2     H N N 415 
VAL HA     H N N 416 
VAL HB     H N N 417 
VAL HG11   H N N 418 
VAL HG12   H N N 419 
VAL HG13   H N N 420 
VAL HG21   H N N 421 
VAL HG22   H N N 422 
VAL HG23   H N N 423 
VAL HXT    H N N 424 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ANP PG    O1G    doub N N 13  
ANP PG    O2G    sing N N 14  
ANP PG    O3G    sing N N 15  
ANP PG    N3B    sing N N 16  
ANP O2G   HOG2   sing N N 17  
ANP O3G   HOG3   sing N N 18  
ANP PB    O1B    doub N N 19  
ANP PB    O2B    sing N N 20  
ANP PB    N3B    sing N N 21  
ANP PB    O3A    sing N N 22  
ANP O2B   HOB2   sing N N 23  
ANP N3B   HNB1   sing N N 24  
ANP PA    O1A    doub N N 25  
ANP PA    O2A    sing N N 26  
ANP PA    O3A    sing N N 27  
ANP PA    "O5'"  sing N N 28  
ANP O2A   HOA2   sing N N 29  
ANP "O5'" "C5'"  sing N N 30  
ANP "C5'" "C4'"  sing N N 31  
ANP "C5'" "H5'1" sing N N 32  
ANP "C5'" "H5'2" sing N N 33  
ANP "C4'" "O4'"  sing N N 34  
ANP "C4'" "C3'"  sing N N 35  
ANP "C4'" "H4'"  sing N N 36  
ANP "O4'" "C1'"  sing N N 37  
ANP "C3'" "O3'"  sing N N 38  
ANP "C3'" "C2'"  sing N N 39  
ANP "C3'" "H3'"  sing N N 40  
ANP "O3'" "HO3'" sing N N 41  
ANP "C2'" "O2'"  sing N N 42  
ANP "C2'" "C1'"  sing N N 43  
ANP "C2'" "H2'"  sing N N 44  
ANP "O2'" "HO2'" sing N N 45  
ANP "C1'" N9     sing N N 46  
ANP "C1'" "H1'"  sing N N 47  
ANP N9    C8     sing Y N 48  
ANP N9    C4     sing Y N 49  
ANP C8    N7     doub Y N 50  
ANP C8    H8     sing N N 51  
ANP N7    C5     sing Y N 52  
ANP C5    C6     sing Y N 53  
ANP C5    C4     doub Y N 54  
ANP C6    N6     sing N N 55  
ANP C6    N1     doub Y N 56  
ANP N6    HN61   sing N N 57  
ANP N6    HN62   sing N N 58  
ANP N1    C2     sing Y N 59  
ANP C2    N3     doub Y N 60  
ANP C2    H2     sing N N 61  
ANP N3    C4     sing Y N 62  
ARG N     CA     sing N N 63  
ARG N     H      sing N N 64  
ARG N     H2     sing N N 65  
ARG CA    C      sing N N 66  
ARG CA    CB     sing N N 67  
ARG CA    HA     sing N N 68  
ARG C     O      doub N N 69  
ARG C     OXT    sing N N 70  
ARG CB    CG     sing N N 71  
ARG CB    HB2    sing N N 72  
ARG CB    HB3    sing N N 73  
ARG CG    CD     sing N N 74  
ARG CG    HG2    sing N N 75  
ARG CG    HG3    sing N N 76  
ARG CD    NE     sing N N 77  
ARG CD    HD2    sing N N 78  
ARG CD    HD3    sing N N 79  
ARG NE    CZ     sing N N 80  
ARG NE    HE     sing N N 81  
ARG CZ    NH1    sing N N 82  
ARG CZ    NH2    doub N N 83  
ARG NH1   HH11   sing N N 84  
ARG NH1   HH12   sing N N 85  
ARG NH2   HH21   sing N N 86  
ARG NH2   HH22   sing N N 87  
ARG OXT   HXT    sing N N 88  
ASN N     CA     sing N N 89  
ASN N     H      sing N N 90  
ASN N     H2     sing N N 91  
ASN CA    C      sing N N 92  
ASN CA    CB     sing N N 93  
ASN CA    HA     sing N N 94  
ASN C     O      doub N N 95  
ASN C     OXT    sing N N 96  
ASN CB    CG     sing N N 97  
ASN CB    HB2    sing N N 98  
ASN CB    HB3    sing N N 99  
ASN CG    OD1    doub N N 100 
ASN CG    ND2    sing N N 101 
ASN ND2   HD21   sing N N 102 
ASN ND2   HD22   sing N N 103 
ASN OXT   HXT    sing N N 104 
ASP N     CA     sing N N 105 
ASP N     H      sing N N 106 
ASP N     H2     sing N N 107 
ASP CA    C      sing N N 108 
ASP CA    CB     sing N N 109 
ASP CA    HA     sing N N 110 
ASP C     O      doub N N 111 
ASP C     OXT    sing N N 112 
ASP CB    CG     sing N N 113 
ASP CB    HB2    sing N N 114 
ASP CB    HB3    sing N N 115 
ASP CG    OD1    doub N N 116 
ASP CG    OD2    sing N N 117 
ASP OD2   HD2    sing N N 118 
ASP OXT   HXT    sing N N 119 
GLN N     CA     sing N N 120 
GLN N     H      sing N N 121 
GLN N     H2     sing N N 122 
GLN CA    C      sing N N 123 
GLN CA    CB     sing N N 124 
GLN CA    HA     sing N N 125 
GLN C     O      doub N N 126 
GLN C     OXT    sing N N 127 
GLN CB    CG     sing N N 128 
GLN CB    HB2    sing N N 129 
GLN CB    HB3    sing N N 130 
GLN CG    CD     sing N N 131 
GLN CG    HG2    sing N N 132 
GLN CG    HG3    sing N N 133 
GLN CD    OE1    doub N N 134 
GLN CD    NE2    sing N N 135 
GLN NE2   HE21   sing N N 136 
GLN NE2   HE22   sing N N 137 
GLN OXT   HXT    sing N N 138 
GLU N     CA     sing N N 139 
GLU N     H      sing N N 140 
GLU N     H2     sing N N 141 
GLU CA    C      sing N N 142 
GLU CA    CB     sing N N 143 
GLU CA    HA     sing N N 144 
GLU C     O      doub N N 145 
GLU C     OXT    sing N N 146 
GLU CB    CG     sing N N 147 
GLU CB    HB2    sing N N 148 
GLU CB    HB3    sing N N 149 
GLU CG    CD     sing N N 150 
GLU CG    HG2    sing N N 151 
GLU CG    HG3    sing N N 152 
GLU CD    OE1    doub N N 153 
GLU CD    OE2    sing N N 154 
GLU OE2   HE2    sing N N 155 
GLU OXT   HXT    sing N N 156 
GLY N     CA     sing N N 157 
GLY N     H      sing N N 158 
GLY N     H2     sing N N 159 
GLY CA    C      sing N N 160 
GLY CA    HA2    sing N N 161 
GLY CA    HA3    sing N N 162 
GLY C     O      doub N N 163 
GLY C     OXT    sing N N 164 
GLY OXT   HXT    sing N N 165 
HIS N     CA     sing N N 166 
HIS N     H      sing N N 167 
HIS N     H2     sing N N 168 
HIS CA    C      sing N N 169 
HIS CA    CB     sing N N 170 
HIS CA    HA     sing N N 171 
HIS C     O      doub N N 172 
HIS C     OXT    sing N N 173 
HIS CB    CG     sing N N 174 
HIS CB    HB2    sing N N 175 
HIS CB    HB3    sing N N 176 
HIS CG    ND1    sing Y N 177 
HIS CG    CD2    doub Y N 178 
HIS ND1   CE1    doub Y N 179 
HIS ND1   HD1    sing N N 180 
HIS CD2   NE2    sing Y N 181 
HIS CD2   HD2    sing N N 182 
HIS CE1   NE2    sing Y N 183 
HIS CE1   HE1    sing N N 184 
HIS NE2   HE2    sing N N 185 
HIS OXT   HXT    sing N N 186 
HOH O     H1     sing N N 187 
HOH O     H2     sing N N 188 
ILE N     CA     sing N N 189 
ILE N     H      sing N N 190 
ILE N     H2     sing N N 191 
ILE CA    C      sing N N 192 
ILE CA    CB     sing N N 193 
ILE CA    HA     sing N N 194 
ILE C     O      doub N N 195 
ILE C     OXT    sing N N 196 
ILE CB    CG1    sing N N 197 
ILE CB    CG2    sing N N 198 
ILE CB    HB     sing N N 199 
ILE CG1   CD1    sing N N 200 
ILE CG1   HG12   sing N N 201 
ILE CG1   HG13   sing N N 202 
ILE CG2   HG21   sing N N 203 
ILE CG2   HG22   sing N N 204 
ILE CG2   HG23   sing N N 205 
ILE CD1   HD11   sing N N 206 
ILE CD1   HD12   sing N N 207 
ILE CD1   HD13   sing N N 208 
ILE OXT   HXT    sing N N 209 
LEU N     CA     sing N N 210 
LEU N     H      sing N N 211 
LEU N     H2     sing N N 212 
LEU CA    C      sing N N 213 
LEU CA    CB     sing N N 214 
LEU CA    HA     sing N N 215 
LEU C     O      doub N N 216 
LEU C     OXT    sing N N 217 
LEU CB    CG     sing N N 218 
LEU CB    HB2    sing N N 219 
LEU CB    HB3    sing N N 220 
LEU CG    CD1    sing N N 221 
LEU CG    CD2    sing N N 222 
LEU CG    HG     sing N N 223 
LEU CD1   HD11   sing N N 224 
LEU CD1   HD12   sing N N 225 
LEU CD1   HD13   sing N N 226 
LEU CD2   HD21   sing N N 227 
LEU CD2   HD22   sing N N 228 
LEU CD2   HD23   sing N N 229 
LEU OXT   HXT    sing N N 230 
LYS N     CA     sing N N 231 
LYS N     H      sing N N 232 
LYS N     H2     sing N N 233 
LYS CA    C      sing N N 234 
LYS CA    CB     sing N N 235 
LYS CA    HA     sing N N 236 
LYS C     O      doub N N 237 
LYS C     OXT    sing N N 238 
LYS CB    CG     sing N N 239 
LYS CB    HB2    sing N N 240 
LYS CB    HB3    sing N N 241 
LYS CG    CD     sing N N 242 
LYS CG    HG2    sing N N 243 
LYS CG    HG3    sing N N 244 
LYS CD    CE     sing N N 245 
LYS CD    HD2    sing N N 246 
LYS CD    HD3    sing N N 247 
LYS CE    NZ     sing N N 248 
LYS CE    HE2    sing N N 249 
LYS CE    HE3    sing N N 250 
LYS NZ    HZ1    sing N N 251 
LYS NZ    HZ2    sing N N 252 
LYS NZ    HZ3    sing N N 253 
LYS OXT   HXT    sing N N 254 
MET N     CA     sing N N 255 
MET N     H      sing N N 256 
MET N     H2     sing N N 257 
MET CA    C      sing N N 258 
MET CA    CB     sing N N 259 
MET CA    HA     sing N N 260 
MET C     O      doub N N 261 
MET C     OXT    sing N N 262 
MET CB    CG     sing N N 263 
MET CB    HB2    sing N N 264 
MET CB    HB3    sing N N 265 
MET CG    SD     sing N N 266 
MET CG    HG2    sing N N 267 
MET CG    HG3    sing N N 268 
MET SD    CE     sing N N 269 
MET CE    HE1    sing N N 270 
MET CE    HE2    sing N N 271 
MET CE    HE3    sing N N 272 
MET OXT   HXT    sing N N 273 
PHE N     CA     sing N N 274 
PHE N     H      sing N N 275 
PHE N     H2     sing N N 276 
PHE CA    C      sing N N 277 
PHE CA    CB     sing N N 278 
PHE CA    HA     sing N N 279 
PHE C     O      doub N N 280 
PHE C     OXT    sing N N 281 
PHE CB    CG     sing N N 282 
PHE CB    HB2    sing N N 283 
PHE CB    HB3    sing N N 284 
PHE CG    CD1    doub Y N 285 
PHE CG    CD2    sing Y N 286 
PHE CD1   CE1    sing Y N 287 
PHE CD1   HD1    sing N N 288 
PHE CD2   CE2    doub Y N 289 
PHE CD2   HD2    sing N N 290 
PHE CE1   CZ     doub Y N 291 
PHE CE1   HE1    sing N N 292 
PHE CE2   CZ     sing Y N 293 
PHE CE2   HE2    sing N N 294 
PHE CZ    HZ     sing N N 295 
PHE OXT   HXT    sing N N 296 
PRO N     CA     sing N N 297 
PRO N     CD     sing N N 298 
PRO N     H      sing N N 299 
PRO CA    C      sing N N 300 
PRO CA    CB     sing N N 301 
PRO CA    HA     sing N N 302 
PRO C     O      doub N N 303 
PRO C     OXT    sing N N 304 
PRO CB    CG     sing N N 305 
PRO CB    HB2    sing N N 306 
PRO CB    HB3    sing N N 307 
PRO CG    CD     sing N N 308 
PRO CG    HG2    sing N N 309 
PRO CG    HG3    sing N N 310 
PRO CD    HD2    sing N N 311 
PRO CD    HD3    sing N N 312 
PRO OXT   HXT    sing N N 313 
SER N     CA     sing N N 314 
SER N     H      sing N N 315 
SER N     H2     sing N N 316 
SER CA    C      sing N N 317 
SER CA    CB     sing N N 318 
SER CA    HA     sing N N 319 
SER C     O      doub N N 320 
SER C     OXT    sing N N 321 
SER CB    OG     sing N N 322 
SER CB    HB2    sing N N 323 
SER CB    HB3    sing N N 324 
SER OG    HG     sing N N 325 
SER OXT   HXT    sing N N 326 
THR N     CA     sing N N 327 
THR N     H      sing N N 328 
THR N     H2     sing N N 329 
THR CA    C      sing N N 330 
THR CA    CB     sing N N 331 
THR CA    HA     sing N N 332 
THR C     O      doub N N 333 
THR C     OXT    sing N N 334 
THR CB    OG1    sing N N 335 
THR CB    CG2    sing N N 336 
THR CB    HB     sing N N 337 
THR OG1   HG1    sing N N 338 
THR CG2   HG21   sing N N 339 
THR CG2   HG22   sing N N 340 
THR CG2   HG23   sing N N 341 
THR OXT   HXT    sing N N 342 
TRP N     CA     sing N N 343 
TRP N     H      sing N N 344 
TRP N     H2     sing N N 345 
TRP CA    C      sing N N 346 
TRP CA    CB     sing N N 347 
TRP CA    HA     sing N N 348 
TRP C     O      doub N N 349 
TRP C     OXT    sing N N 350 
TRP CB    CG     sing N N 351 
TRP CB    HB2    sing N N 352 
TRP CB    HB3    sing N N 353 
TRP CG    CD1    doub Y N 354 
TRP CG    CD2    sing Y N 355 
TRP CD1   NE1    sing Y N 356 
TRP CD1   HD1    sing N N 357 
TRP CD2   CE2    doub Y N 358 
TRP CD2   CE3    sing Y N 359 
TRP NE1   CE2    sing Y N 360 
TRP NE1   HE1    sing N N 361 
TRP CE2   CZ2    sing Y N 362 
TRP CE3   CZ3    doub Y N 363 
TRP CE3   HE3    sing N N 364 
TRP CZ2   CH2    doub Y N 365 
TRP CZ2   HZ2    sing N N 366 
TRP CZ3   CH2    sing Y N 367 
TRP CZ3   HZ3    sing N N 368 
TRP CH2   HH2    sing N N 369 
TRP OXT   HXT    sing N N 370 
TYR N     CA     sing N N 371 
TYR N     H      sing N N 372 
TYR N     H2     sing N N 373 
TYR CA    C      sing N N 374 
TYR CA    CB     sing N N 375 
TYR CA    HA     sing N N 376 
TYR C     O      doub N N 377 
TYR C     OXT    sing N N 378 
TYR CB    CG     sing N N 379 
TYR CB    HB2    sing N N 380 
TYR CB    HB3    sing N N 381 
TYR CG    CD1    doub Y N 382 
TYR CG    CD2    sing Y N 383 
TYR CD1   CE1    sing Y N 384 
TYR CD1   HD1    sing N N 385 
TYR CD2   CE2    doub Y N 386 
TYR CD2   HD2    sing N N 387 
TYR CE1   CZ     doub Y N 388 
TYR CE1   HE1    sing N N 389 
TYR CE2   CZ     sing Y N 390 
TYR CE2   HE2    sing N N 391 
TYR CZ    OH     sing N N 392 
TYR OH    HH     sing N N 393 
TYR OXT   HXT    sing N N 394 
VAL N     CA     sing N N 395 
VAL N     H      sing N N 396 
VAL N     H2     sing N N 397 
VAL CA    C      sing N N 398 
VAL CA    CB     sing N N 399 
VAL CA    HA     sing N N 400 
VAL C     O      doub N N 401 
VAL C     OXT    sing N N 402 
VAL CB    CG1    sing N N 403 
VAL CB    CG2    sing N N 404 
VAL CB    HB     sing N N 405 
VAL CG1   HG11   sing N N 406 
VAL CG1   HG12   sing N N 407 
VAL CG1   HG13   sing N N 408 
VAL CG2   HG21   sing N N 409 
VAL CG2   HG22   sing N N 410 
VAL CG2   HG23   sing N N 411 
VAL OXT   HXT    sing N N 412 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           T32GM148376-01A1 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6CJI 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 2 2' 
_space_group.name_Hall        'P 4cw 2c' 
_space_group.IT_number        95 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9MTB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013484 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013484 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009293 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N      . LYS A 1 5   ? 30.73000 14.54200  4.37800   1.000 62.61000  ? 5   LYS A N      1 
ATOM   2    C CA     . LYS A 1 5   ? 29.52100 15.35600  4.25000   1.000 70.53000  ? 5   LYS A CA     1 
ATOM   3    C C      . LYS A 1 5   ? 28.24500 14.48400  4.38100   1.000 71.79000  ? 5   LYS A C      1 
ATOM   4    O O      . LYS A 1 5   ? 27.74700 13.88600  3.42100   1.000 47.94000  ? 5   LYS A O      1 
ATOM   5    C CB     . LYS A 1 5   ? 29.55500 16.11000  2.92200   1.000 57.54000  ? 5   LYS A CB     1 
ATOM   6    H HA     . LYS A 1 5   ? 29.48000 16.01300  4.96200   1.000 85.01000  ? 5   LYS A HA     1 
ATOM   7    N N      . VAL A 1 6   ? 27.70900 14.40800  5.59400   1.000 58.63000  ? 6   VAL A N      1 
ATOM   8    C CA     . VAL A 1 6   ? 26.68900 13.42700  5.90300   1.000 56.14000  ? 6   VAL A CA     1 
ATOM   9    C C      . VAL A 1 6   ? 25.27900 13.97000  5.93200   1.000 64.28000  ? 6   VAL A C      1 
ATOM   10   O O      . VAL A 1 6   ? 24.86300 14.54000  6.94200   1.000 80.50000  ? 6   VAL A O      1 
ATOM   11   C CB     . VAL A 1 6   ? 26.97300 12.76000  7.26100   1.000 30.00000  ? 6   VAL A CB     1 
ATOM   12   H H      . VAL A 1 6   ? 27.91800 14.91300  6.25800   1.000 58.63000  ? 6   VAL A H      1 
ATOM   13   H HA     . VAL A 1 6   ? 26.73600 12.78800  5.17500   1.000 56.14000  ? 6   VAL A HA     1 
ATOM   14   N N      . GLU A 1 7   ? 24.52000 13.77400  4.85500   1.000 61.39000  ? 7   GLU A N      1 
ATOM   15   C CA     . GLU A 1 7   ? 23.12700 14.20000  4.84800   1.000 59.89000  ? 7   GLU A CA     1 
ATOM   16   C C      . GLU A 1 7   ? 22.26800 13.31800  5.75000   1.000 65.39000  ? 7   GLU A C      1 
ATOM   17   O O      . GLU A 1 7   ? 22.27700 12.08800  5.60300   1.000 65.91000  ? 7   GLU A O      1 
ATOM   18   C CB     . GLU A 1 7   ? 22.56600 14.14600  3.43700   1.000 62.10000  ? 7   GLU A CB     1 
ATOM   19   C CG     . GLU A 1 7   ? 22.88600 15.30200  2.53700   1.000 83.02000  ? 7   GLU A CG     1 
ATOM   20   C CD     . GLU A 1 7   ? 22.19700 15.11600  1.19600   1.000 87.55000  ? 7   GLU A CD     1 
ATOM   21   O OE1    . GLU A 1 7   ? 21.33600 14.20200  1.09500   1.000 84.31000  ? 7   GLU A OE1    1 
ATOM   22   O OE2    . GLU A 1 7   ? 22.50500 15.86600  0.24800   1.000 92.69000  ? 7   GLU A OE2    1 
ATOM   23   H H      . GLU A 1 7   ? 24.78600 13.40100  4.12700   1.000 74.05000  ? 7   GLU A H      1 
ATOM   24   H HA     . GLU A 1 7   ? 23.09000 15.11100  5.18000   1.000 72.25000  ? 7   GLU A HA     1 
ATOM   25   H HB2    . GLU A 1 7   ? 22.91300 13.34900  3.00800   1.000 74.90000  ? 7   GLU A HB2    1 
ATOM   26   H HB3    . GLU A 1 7   ? 21.60000 14.09600  3.50000   1.000 74.90000  ? 7   GLU A HB3    1 
ATOM   27   H HG2    . GLU A 1 7   ? 22.57100 16.12700  2.93800   1.000 100.01000 ? 7   GLU A HG2    1 
ATOM   28   H HG3    . GLU A 1 7   ? 23.84400 15.34900  2.39200   1.000 100.01000 ? 7   GLU A HG3    1 
ATOM   29   N N      . THR A 1 8   ? 21.49300 13.94700  6.64400   1.000 58.04000  ? 8   THR A N      1 
ATOM   30   C CA     . THR A 1 8   ? 20.53900 13.24500  7.47900   1.000 50.96000  ? 8   THR A CA     1 
ATOM   31   C C      . THR A 1 8   ? 19.11000 13.42200  6.98400   1.000 50.93000  ? 8   THR A C      1 
ATOM   32   O O      . THR A 1 8   ? 18.74600 14.44700  6.40900   1.000 58.98000  ? 8   THR A O      1 
ATOM   33   C CB     . THR A 1 8   ? 20.62100 13.72100  8.91600   1.000 58.28000  ? 8   THR A CB     1 
ATOM   34   O OG1    . THR A 1 8   ? 21.96700 13.60400  9.35600   1.000 63.92000  ? 8   THR A OG1    1 
ATOM   35   C CG2    . THR A 1 8   ? 19.68600 12.90300  9.80500   1.000 75.01000  ? 8   THR A CG2    1 
ATOM   36   H H      . THR A 1 8   ? 21.51100 14.79600  6.78000   1.000 70.04000  ? 8   THR A H      1 
ATOM   37   H HA     . THR A 1 8   ? 20.75200 12.29900  7.44100   1.000 61.53000  ? 8   THR A HA     1 
ATOM   38   H HB     . THR A 1 8   ? 20.34300 14.64800  8.98700   1.000 70.31000  ? 8   THR A HB     1 
ATOM   39   H HG1    . THR A 1 8   ? 22.02100 13.79600  10.17100  1.000 77.08000  ? 8   THR A HG1    1 
ATOM   40   H HG21   . THR A 1 8   ? 19.79200 13.17000  10.73200  1.000 90.39000  ? 8   THR A HG21   1 
ATOM   41   H HG22   . THR A 1 8   ? 18.76500 13.04800  9.53900   1.000 90.39000  ? 8   THR A HG22   1 
ATOM   42   H HG23   . THR A 1 8   ? 19.89300 11.95900  9.72300   1.000 90.39000  ? 8   THR A HG23   1 
ATOM   43   N N      . HIS A 1 9   ? 18.32600 12.37200  7.14900   1.000 53.45000  ? 9   HIS A N      1 
ATOM   44   C CA     . HIS A 1 9   ? 16.90800 12.38300  6.76400   1.000 68.59000  ? 9   HIS A CA     1 
ATOM   45   C C      . HIS A 1 9   ? 16.16300 11.64500  7.86100   1.000 66.21000  ? 9   HIS A C      1 
ATOM   46   O O      . HIS A 1 9   ? 16.83500 11.13600  8.74000   1.000 66.41000  ? 9   HIS A O      1 
ATOM   47   C CB     . HIS A 1 9   ? 16.71500 11.66200  5.44000   1.000 65.96000  ? 9   HIS A CB     1 
ATOM   48   C CG     . HIS A 1 9   ? 17.49200 12.21600  4.30200   1.000 74.22000  ? 9   HIS A CG     1 
ATOM   49   N ND1    . HIS A 1 9   ? 18.75500 11.76100  4.00400   1.000 63.67000  ? 9   HIS A ND1    1 
ATOM   50   C CD2    . HIS A 1 9   ? 17.20500 13.14300  3.39100   1.000 85.70000  ? 9   HIS A CD2    1 
ATOM   51   C CE1    . HIS A 1 9   ? 19.21200 12.41300  2.95000   1.000 75.49000  ? 9   HIS A CE1    1 
ATOM   52   N NE2    . HIS A 1 9   ? 18.28500 13.25700  2.56000   1.000 95.76000  ? 9   HIS A NE2    1 
ATOM   53   H H      . HIS A 1 9   ? 18.60400 11.58400  7.49200   1.000 64.53000  ? 9   HIS A H      1 
ATOM   54   H HA     . HIS A 1 9   ? 16.56100 13.30500  6.71200   1.000 82.69000  ? 9   HIS A HA     1 
ATOM   55   H HB2    . HIS A 1 9   ? 16.98500 10.73400  5.57500   1.000 79.54000  ? 9   HIS A HB2    1 
ATOM   56   H HB3    . HIS A 1 9   ? 15.76200 11.66900  5.21100   1.000 79.54000  ? 9   HIS A HB3    1 
ATOM   57   H HD2    . HIS A 1 9   ? 16.41100 13.63600  3.32900   1.000 103.22000 ? 9   HIS A HD2    1 
ATOM   58   H HE1    . HIS A 1 9   ? 20.05400 12.28900  2.54800   1.000 90.98000  ? 9   HIS A HE1    1 
ATOM   59   H HE2    . HIS A 1 9   ? 18.35100 13.80200  1.87800   1.000 115.30000 ? 9   HIS A HE2    1 
ATOM   60   N N      . GLU A 1 10  ? 14.84400 11.68300  7.85800   1.000 66.59000  ? 10  GLU A N      1 
ATOM   61   C CA     . GLU A 1 10  ? 14.00100 10.97400  8.80700   1.000 75.06000  ? 10  GLU A CA     1 
ATOM   62   C C      . GLU A 1 10  ? 13.20000 9.89500   8.08300   1.000 60.68000  ? 10  GLU A C      1 
ATOM   63   O O      . GLU A 1 10  ? 12.83500 10.02800  6.91300   1.000 43.18000  ? 10  GLU A O      1 
ATOM   64   C CB     . GLU A 1 10  ? 13.07700 11.95700  9.54900   1.000 74.73000  ? 10  GLU A CB     1 
ATOM   65   C CG     . GLU A 1 10  ? 13.81000 13.04400  10.36200  1.000 96.88000  ? 10  GLU A CG     1 
ATOM   66   C CD     . GLU A 1 10  ? 14.20000 14.28600  9.52500   1.000 119.92000 ? 10  GLU A CD     1 
ATOM   67   O OE1    . GLU A 1 10  ? 14.16900 14.21800  8.26100   1.000 101.53000 ? 10  GLU A OE1    1 
ATOM   68   O OE2    . GLU A 1 10  ? 14.54300 15.33800  10.13900  1.000 108.11000 ? 10  GLU A OE2    1 
ATOM   69   H H      . GLU A 1 10  ? 14.41300 12.21100  7.33400   1.000 80.29000  ? 10  GLU A H      1 
ATOM   70   H HA     . GLU A 1 10  ? 14.54300 10.52600  9.47600   1.000 90.45000  ? 10  GLU A HA     1 
ATOM   71   H HB2    . GLU A 1 10  ? 12.51900 12.40700  8.89600   1.000 90.06000  ? 10  GLU A HB2    1 
ATOM   72   H HB3    . GLU A 1 10  ? 12.52400 11.45300  10.16700  1.000 90.06000  ? 10  GLU A HB3    1 
ATOM   73   H HG2    . GLU A 1 10  ? 13.23100 13.34100  11.08200  1.000 116.64000 ? 10  GLU A HG2    1 
ATOM   74   H HG3    . GLU A 1 10  ? 14.62500 12.66500  10.72700  1.000 116.64000 ? 10  GLU A HG3    1 
ATOM   75   N N      . PHE A 1 11  ? 12.98100 8.78600   8.77200   1.000 71.74000  ? 11  PHE A N      1 
ATOM   76   C CA     . PHE A 1 11  ? 12.13900 7.74100   8.20900   1.000 77.48000  ? 11  PHE A CA     1 
ATOM   77   C C      . PHE A 1 11  ? 10.67900 8.17600   8.21300   1.000 72.51000  ? 11  PHE A C      1 
ATOM   78   O O      . PHE A 1 11  ? 10.20300 8.78100   9.18000   1.000 72.25000  ? 11  PHE A O      1 
ATOM   79   C CB     . PHE A 1 11  ? 12.27100 6.44500   9.01200   1.000 81.92000  ? 11  PHE A CB     1 
ATOM   80   C CG     . PHE A 1 11  ? 13.47300 5.64500   8.66200   1.000 70.40000  ? 11  PHE A CG     1 
ATOM   81   C CD1    . PHE A 1 11  ? 13.55200 4.99700   7.44300   1.000 71.42000  ? 11  PHE A CD1    1 
ATOM   82   C CD2    . PHE A 1 11  ? 14.53100 5.55200   9.54300   1.000 80.08000  ? 11  PHE A CD2    1 
ATOM   83   C CE1    . PHE A 1 11  ? 14.66100 4.28500   7.10500   1.000 56.02000  ? 11  PHE A CE1    1 
ATOM   84   C CE2    . PHE A 1 11  ? 15.65000 4.82200   9.22800   1.000 71.04000  ? 11  PHE A CE2    1 
ATOM   85   C CZ     . PHE A 1 11  ? 15.72200 4.19000   8.01200   1.000 71.69000  ? 11  PHE A CZ     1 
ATOM   86   H H      . PHE A 1 11  ? 13.30100 8.61700   9.55200   1.000 86.47000  ? 11  PHE A H      1 
ATOM   87   H HA     . PHE A 1 11  ? 12.42100 7.57200   7.29600   1.000 93.35000  ? 11  PHE A HA     1 
ATOM   88   H HB2    . PHE A 1 11  ? 12.32600 6.66600   9.95500   1.000 98.69000  ? 11  PHE A HB2    1 
ATOM   89   H HB3    . PHE A 1 11  ? 11.49000 5.89400   8.84600   1.000 98.69000  ? 11  PHE A HB3    1 
ATOM   90   H HD1    . PHE A 1 11  ? 12.84000 5.04900   6.84800   1.000 86.08000  ? 11  PHE A HD1    1 
ATOM   91   H HD2    . PHE A 1 11  ? 14.48500 5.99000   10.36200  1.000 96.48000  ? 11  PHE A HD2    1 
ATOM   92   H HE1    . PHE A 1 11  ? 14.71200 3.86500   6.27700   1.000 67.61000  ? 11  PHE A HE1    1 
ATOM   93   H HE2    . PHE A 1 11  ? 16.35200 4.75600   9.83400   1.000 85.62000  ? 11  PHE A HE2    1 
ATOM   94   H HZ     . PHE A 1 11  ? 16.47900 3.69700   7.78900   1.000 86.41000  ? 11  PHE A HZ     1 
ATOM   95   N N      . THR A 1 12  ? 9.95600  7.85300   7.13900   1.000 62.71000  ? 12  THR A N      1 
ATOM   96   C CA     . THR A 1 12  ? 8.50800  7.87000   7.25700   1.000 66.07000  ? 12  THR A CA     1 
ATOM   97   C C      . THR A 1 12  ? 8.13300  7.05500   8.49200   1.000 73.46000  ? 12  THR A C      1 
ATOM   98   O O      . THR A 1 12  ? 8.81900  6.09400   8.86800   1.000 75.25000  ? 12  THR A O      1 
ATOM   99   C CB     . THR A 1 12  ? 7.83000  7.30500   6.02300   1.000 65.64000  ? 12  THR A CB     1 
ATOM   100  O OG1    . THR A 1 12  ? 8.04700  5.89800   5.97400   1.000 77.36000  ? 12  THR A OG1    1 
ATOM   101  C CG2    . THR A 1 12  ? 8.37500  7.95600   4.77600   1.000 76.07000  ? 12  THR A CG2    1 
ATOM   102  H H      . THR A 1 12  ? 10.27000 7.63100   6.36900   1.000 75.64000  ? 12  THR A H      1 
ATOM   103  H HA     . THR A 1 12  ? 8.18900  8.78300   7.34000   1.000 79.66000  ? 12  THR A HA     1 
ATOM   104  H HB     . THR A 1 12  ? 6.87700  7.48100   6.05800   1.000 79.15000  ? 12  THR A HB     1 
ATOM   105  H HG1    . THR A 1 12  ? 7.72600  5.58300   5.26500   1.000 93.21000  ? 12  THR A HG1    1 
ATOM   106  H HG21   . THR A 1 12  ? 7.95800  7.57000   3.99000   1.000 91.67000  ? 12  THR A HG21   1 
ATOM   107  H HG22   . THR A 1 12  ? 8.19400  8.90900   4.79300   1.000 91.67000  ? 12  THR A HG22   1 
ATOM   108  H HG23   . THR A 1 12  ? 9.33400  7.81900   4.72200   1.000 91.67000  ? 12  THR A HG23   1 
ATOM   109  N N      . ALA A 1 13  ? 7.08000  7.47900   9.18300   1.000 77.76000  ? 13  ALA A N      1 
ATOM   110  C CA     . ALA A 1 13  ? 6.72500  6.79600   10.42000  1.000 73.24000  ? 13  ALA A CA     1 
ATOM   111  C C      . ALA A 1 13  ? 6.37000  5.33600   10.15700  1.000 75.23000  ? 13  ALA A C      1 
ATOM   112  O O      . ALA A 1 13  ? 6.65500  4.46000   10.98300  1.000 59.36000  ? 13  ALA A O      1 
ATOM   113  C CB     . ALA A 1 13  ? 5.56900  7.52000   11.11100  1.000 74.67000  ? 13  ALA A CB     1 
ATOM   114  H H      . ALA A 1 13  ? 6.57100  8.13700   8.96500   1.000 93.70000  ? 13  ALA A H      1 
ATOM   115  H HA     . ALA A 1 13  ? 7.48200  6.81800   11.02600  1.000 88.27000  ? 13  ALA A HA     1 
ATOM   116  H HB1    . ALA A 1 13  ? 5.42300  7.12100   11.98300  1.000 89.99000  ? 13  ALA A HB1    1 
ATOM   117  H HB2    . ALA A 1 13  ? 5.79800  8.45700   11.21000  1.000 89.99000  ? 13  ALA A HB2    1 
ATOM   118  H HB3    . ALA A 1 13  ? 4.77000  7.43000   10.56800  1.000 89.99000  ? 13  ALA A HB3    1 
ATOM   119  N N      . GLU A 1 14  ? 5.73400  5.05200   9.02000   1.000 79.69000  ? 14  GLU A N      1 
ATOM   120  C CA     . GLU A 1 14  ? 5.38300  3.67000   8.71400   1.000 84.00000  ? 14  GLU A CA     1 
ATOM   121  C C      . GLU A 1 14  ? 6.64100  2.80400   8.67100   1.000 74.97000  ? 14  GLU A C      1 
ATOM   122  O O      . GLU A 1 14  ? 6.79900  1.86100   9.46300   1.000 75.63000  ? 14  GLU A O      1 
ATOM   123  C CB     . GLU A 1 14  ? 4.61700  3.59100   7.38700   1.000 85.19000  ? 14  GLU A CB     1 
ATOM   124  C CG     . GLU A 1 14  ? 3.44900  4.56700   7.24400   1.000 102.96000 ? 14  GLU A CG     1 
ATOM   125  C CD     . GLU A 1 14  ? 3.89400  6.02800   7.02000   1.000 113.10000 ? 14  GLU A CD     1 
ATOM   126  O OE1    . GLU A 1 14  ? 4.45800  6.60500   7.98400   1.000 118.39000 ? 14  GLU A OE1    1 
ATOM   127  O OE2    . GLU A 1 14  ? 3.72600  6.58000   5.90500   1.000 109.70000 ? 14  GLU A OE2    1 
ATOM   128  H H      . GLU A 1 14  ? 5.50100  5.62800   8.42600   1.000 96.01000  ? 14  GLU A H      1 
ATOM   129  H HA     . GLU A 1 14  ? 4.79400  3.33100   9.40600   1.000 101.18000 ? 14  GLU A HA     1 
ATOM   130  H HB2    . GLU A 1 14  ? 5.23800  3.77500   6.66500   1.000 102.61000 ? 14  GLU A HB2    1 
ATOM   131  H HB3    . GLU A 1 14  ? 4.25800  2.69500   7.29500   1.000 102.61000 ? 14  GLU A HB3    1 
ATOM   132  H HG2    . GLU A 1 14  ? 2.91000  4.30100   6.48300   1.000 123.94000 ? 14  GLU A HG2    1 
ATOM   133  H HG3    . GLU A 1 14  ? 2.91700  4.54000   8.05400   1.000 123.94000 ? 14  GLU A HG3    1 
ATOM   134  N N      . ILE A 1 15  ? 7.61400  3.17600   7.84300   1.000 74.84000  ? 15  ILE A N      1 
ATOM   135  C CA     . ILE A 1 15  ? 8.87100  2.38700   7.67900   1.000 71.00000  ? 15  ILE A CA     1 
ATOM   136  C C      . ILE A 1 15  ? 9.51800  2.17500   9.05100   1.000 62.97000  ? 15  ILE A C      1 
ATOM   137  O O      . ILE A 1 15  ? 9.97900  1.06600   9.31100   1.000 53.53000  ? 15  ILE A O      1 
ATOM   138  C CB     . ILE A 1 15  ? 9.81800  3.09000   6.69200   1.000 65.81000  ? 15  ILE A CB     1 
ATOM   139  C CG1    . ILE A 1 15  ? 9.31000  2.98800   5.25400   1.000 78.72000  ? 15  ILE A CG1    1 
ATOM   140  C CG2    . ILE A 1 15  ? 11.25100 2.57300   6.81700   1.000 67.10000  ? 15  ILE A CG2    1 
ATOM   141  C CD1    . ILE A 1 15  ? 9.22100  1.57500   4.70700   1.000 80.07000  ? 15  ILE A CD1    1 
ATOM   142  H H      . ILE A 1 15  ? 7.57200  3.93300   7.35200   1.000 90.19000  ? 15  ILE A H      1 
ATOM   143  H HA     . ILE A 1 15  ? 8.63600  1.51300   7.31500   1.000 85.58000  ? 15  ILE A HA     1 
ATOM   144  H HB     . ILE A 1 15  ? 9.82800  4.03800   6.93000   1.000 79.35000  ? 15  ILE A HB     1 
ATOM   145  H HG12   . ILE A 1 15  ? 8.42000  3.39100   5.20900   1.000 94.85000  ? 15  ILE A HG12   1 
ATOM   146  H HG13   . ILE A 1 15  ? 9.90300  3.51100   4.67700   1.000 94.85000  ? 15  ILE A HG13   1 
ATOM   147  H HG21   . ILE A 1 15  ? 11.76000 2.84000   6.03300   1.000 80.90000  ? 15  ILE A HG21   1 
ATOM   148  H HG22   . ILE A 1 15  ? 11.66800 2.94600   7.61100   1.000 80.90000  ? 15  ILE A HG22   1 
ATOM   149  H HG23   . ILE A 1 15  ? 11.24600 1.60300   6.88000   1.000 80.90000  ? 15  ILE A HG23   1 
ATOM   150  H HD11   . ILE A 1 15  ? 9.27300  1.60400   3.73300   1.000 96.46000  ? 15  ILE A HD11   1 
ATOM   151  H HD12   . ILE A 1 15  ? 9.94900  1.02600   5.05300   1.000 96.46000  ? 15  ILE A HD12   1 
ATOM   152  H HD13   . ILE A 1 15  ? 8.36900  1.18400   4.97400   1.000 96.46000  ? 15  ILE A HD13   1 
ATOM   153  N N      . SER A 1 16  ? 9.54400  3.20300   9.88100   1.000 56.33000  ? 16  SER A N      1 
ATOM   154  C CA     . SER A 1 16  ? 10.16900 3.11300   11.21700  1.000 62.76000  ? 16  SER A CA     1 
ATOM   155  C C      . SER A 1 16  ? 9.44900  2.04800   12.04300  1.000 61.09000  ? 16  SER A C      1 
ATOM   156  O O      . SER A 1 16  ? 10.12000 1.31500   12.77600  1.000 53.18000  ? 16  SER A O      1 
ATOM   157  C CB     . SER A 1 16  ? 10.13100 4.44000   11.87400  1.000 60.45000  ? 16  SER A CB     1 
ATOM   158  O OG     . SER A 1 16  ? 11.01500 4.48500   12.98200  1.000 78.61000  ? 16  SER A OG     1 
ATOM   159  H H      . SER A 1 16  ? 9.17800  3.99800   9.66200   1.000 67.97000  ? 16  SER A H      1 
ATOM   160  H HA     . SER A 1 16  ? 11.11400 2.83900   11.10400  1.000 75.70000  ? 16  SER A HA     1 
ATOM   161  H HB2    . SER A 1 16  ? 10.38300 5.12600   11.22700  1.000 72.92000  ? 16  SER A HB2    1 
ATOM   162  H HB3    . SER A 1 16  ? 9.22100  4.62300   12.17500  1.000 72.92000  ? 16  SER A HB3    1 
ATOM   163  H HG     . SER A 1 16  ? 11.76800 4.19000   12.73400  1.000 94.72000  ? 16  SER A HG     1 
ATOM   164  N N      . GLN A 1 17  ? 8.13500  1.96000   11.90300  1.000 71.05000  ? 17  GLN A N      1 
ATOM   165  C CA     . GLN A 1 17  ? 7.31600  0.99100   12.66400  1.000 75.54000  ? 17  GLN A CA     1 
ATOM   166  C C      . GLN A 1 17  ? 7.54200  -0.41300  12.10700  1.000 67.23000  ? 17  GLN A C      1 
ATOM   167  O O      . GLN A 1 17  ? 7.53300  -1.35800  12.89600  1.000 51.04000  ? 17  GLN A O      1 
ATOM   168  C CB     . GLN A 1 17  ? 5.85200  1.40500   12.56400  1.000 55.96000  ? 17  GLN A CB     1 
ATOM   169  H H      . GLN A 1 17  ? 7.68700  2.49800   11.33500  1.000 85.64000  ? 17  GLN A H      1 
ATOM   170  H HA     . GLN A 1 17  ? 7.60100  1.01000   13.61200  1.000 91.04000  ? 17  GLN A HA     1 
ATOM   171  N N      . LEU A 1 18  ? 7.72200  -0.52500  10.79800  1.000 71.41000  ? 18  LEU A N      1 
ATOM   172  C CA     . LEU A 1 18  ? 8.00700  -1.82600  10.15900  1.000 69.21000  ? 18  LEU A CA     1 
ATOM   173  C C      . LEU A 1 18  ? 9.39400  -2.25300  10.61300  1.000 58.17000  ? 18  LEU A C      1 
ATOM   174  O O      . LEU A 1 18  ? 9.60100  -3.42900  10.76200  1.000 45.00000  ? 18  LEU A O      1 
ATOM   175  C CB     . LEU A 1 18  ? 7.92100  -1.70100  8.64000   1.000 61.68000  ? 18  LEU A CB     1 
ATOM   176  C CG     . LEU A 1 18  ? 8.32100  -2.93400  7.82400   1.000 61.75000  ? 18  LEU A CG     1 
ATOM   177  C CD1    . LEU A 1 18  ? 7.46400  -4.13500  8.16500   1.000 57.02000  ? 18  LEU A CD1    1 
ATOM   178  C CD2    . LEU A 1 18  ? 8.24000  -2.63600  6.34600   1.000 67.99000  ? 18  LEU A CD2    1 
ATOM   179  H H      . LEU A 1 18  ? 7.69200  0.19200   10.25300  1.000 86.08000  ? 18  LEU A H      1 
ATOM   180  H HA     . LEU A 1 18  ? 7.34300  -2.48900  10.47500  1.000 83.43000  ? 18  LEU A HA     1 
ATOM   181  H HB2    . LEU A 1 18  ? 6.99400  -1.46400  8.40500   1.000 74.40000  ? 18  LEU A HB2    1 
ATOM   182  H HB3    . LEU A 1 18  ? 8.49200  -0.94900  8.36300   1.000 74.40000  ? 18  LEU A HB3    1 
ATOM   183  H HG     . LEU A 1 18  ? 9.26300  -3.15700  8.03500   1.000 74.48000  ? 18  LEU A HG     1 
ATOM   184  H HD11   . LEU A 1 18  ? 7.40300  -4.72000  7.39000   1.000 68.80000  ? 18  LEU A HD11   1 
ATOM   185  H HD12   . LEU A 1 18  ? 7.86400  -4.62200  8.90600   1.000 68.80000  ? 18  LEU A HD12   1 
ATOM   186  H HD13   . LEU A 1 18  ? 6.57400  -3.83800  8.41600   1.000 68.80000  ? 18  LEU A HD13   1 
ATOM   187  H HD21   . LEU A 1 18  ? 8.80300  -3.26000  5.85600   1.000 81.97000  ? 18  LEU A HD21   1 
ATOM   188  H HD22   . LEU A 1 18  ? 7.32000  -2.72800  6.04700   1.000 81.97000  ? 18  LEU A HD22   1 
ATOM   189  H HD23   . LEU A 1 18  ? 8.54400  -1.72700  6.18100   1.000 81.97000  ? 18  LEU A HD23   1 
ATOM   190  N N      . MET A 1 19  ? 10.29600 -1.30400  10.79700  1.000 60.62000  ? 19  MET A N      1 
ATOM   191  C CA     . MET A 1 19  ? 11.69400 -1.62000  11.15900  1.000 64.96000  ? 19  MET A CA     1 
ATOM   192  C C      . MET A 1 19  ? 11.71000 -2.09100  12.60400  1.000 61.84000  ? 19  MET A C      1 
ATOM   193  O O      . MET A 1 19  ? 12.52900 -2.93000  12.90400  1.000 49.48000  ? 19  MET A O      1 
ATOM   194  C CB     . MET A 1 19  ? 12.60100 -0.40000  10.99600  1.000 59.31000  ? 19  MET A CB     1 
ATOM   195  C CG     . MET A 1 19  ? 13.15400 -0.23200  9.60400   1.000 54.83000  ? 19  MET A CG     1 
ATOM   196  S SD     . MET A 1 19  ? 14.16200 1.25300   9.45300   1.000 63.04000  ? 19  MET A SD     1 
ATOM   197  C CE     . MET A 1 19  ? 15.08800 0.84000   7.97200   1.000 58.76000  ? 19  MET A CE     1 
ATOM   198  H H      . MET A 1 19  ? 10.08800 -0.43100  10.71100  1.000 73.12000  ? 19  MET A H      1 
ATOM   199  H HA     . MET A 1 19  ? 12.01600 -2.35200  10.57500  1.000 78.33000  ? 19  MET A HA     1 
ATOM   200  H HB2    . MET A 1 19  ? 12.09000 0.40200   11.23300  1.000 71.55000  ? 19  MET A HB2    1 
ATOM   201  H HB3    . MET A 1 19  ? 13.34600 -0.47800  11.62900  1.000 71.55000  ? 19  MET A HB3    1 
ATOM   202  H HG2    . MET A 1 19  ? 13.69800 -1.01000  9.37500   1.000 66.18000  ? 19  MET A HG2    1 
ATOM   203  H HG3    . MET A 1 19  ? 12.41600 -0.18100  8.96400   1.000 66.18000  ? 19  MET A HG3    1 
ATOM   204  H HE1    . MET A 1 19  ? 16.02700 1.07200   8.09900   1.000 70.90000  ? 19  MET A HE1    1 
ATOM   205  H HE2    . MET A 1 19  ? 15.00900 -0.11600  7.79600   1.000 70.90000  ? 19  MET A HE2    1 
ATOM   206  H HE3    . MET A 1 19  ? 14.73000 1.34000   7.21600   1.000 70.90000  ? 19  MET A HE3    1 
ATOM   207  N N      . SER A 1 20  ? 10.84700 -1.53700  13.43900  1.000 72.59000  ? 20  SER A N      1 
ATOM   208  C CA     . SER A 1 20  ? 10.78800 -1.86900  14.87800  1.000 61.66000  ? 20  SER A CA     1 
ATOM   209  C C      . SER A 1 20  ? 10.02700 -3.18000  15.05800  1.000 58.61000  ? 20  SER A C      1 
ATOM   210  O O      . SER A 1 20  ? 10.41200 -3.98100  15.90300  1.000 54.20000  ? 20  SER A O      1 
ATOM   211  C CB     . SER A 1 20  ? 10.15500 -0.75300  15.60600  1.000 65.37000  ? 20  SER A CB     1 
ATOM   212  O OG     . SER A 1 20  ? 10.93200 0.42700   15.48300  1.000 66.23000  ? 20  SER A OG     1 
ATOM   213  H H      . SER A 1 20  ? 10.25200 -0.91900  13.15800  1.000 87.49000  ? 20  SER A H      1 
ATOM   214  H HA     . SER A 1 20  ? 11.70600 -1.98300  15.21500  1.000 74.37000  ? 20  SER A HA     1 
ATOM   215  H HB2    . SER A 1 20  ? 9.26200  -0.59700  15.24200  1.000 78.83000  ? 20  SER A HB2    1 
ATOM   216  H HB3    . SER A 1 20  ? 10.06700 -0.99000  16.54800  1.000 78.83000  ? 20  SER A HB3    1 
ATOM   217  H HG     . SER A 1 20  ? 10.71300 0.82600   14.76900  1.000 79.86000  ? 20  SER A HG     1 
ATOM   218  N N      . LEU A 1 21  ? 8.99900  -3.39000  14.26000  1.000 55.31000  ? 21  LEU A N      1 
ATOM   219  C CA     . LEU A 1 21  ? 8.24700  -4.65500  14.29900  1.000 58.76000  ? 21  LEU A CA     1 
ATOM   220  C C      . LEU A 1 21  ? 9.22800  -5.78300  14.01400  1.000 64.75000  ? 21  LEU A C      1 
ATOM   221  O O      . LEU A 1 21  ? 9.36700  -6.62300  14.88600  1.000 66.44000  ? 21  LEU A O      1 
ATOM   222  C CB     . LEU A 1 21  ? 7.14500  -4.58100  13.25200  1.000 58.85000  ? 21  LEU A CB     1 
ATOM   223  C CG     . LEU A 1 21  ? 6.38700  -5.87300  12.94800  1.000 67.71000  ? 21  LEU A CG     1 
ATOM   224  C CD1    . LEU A 1 21  ? 4.97400  -5.52300  12.55000  1.000 53.67000  ? 21  LEU A CD1    1 
ATOM   225  C CD2    . LEU A 1 21  ? 7.05200  -6.66900  11.85100  1.000 68.40000  ? 21  LEU A CD2    1 
ATOM   226  H H      . LEU A 1 21  ? 8.74100  -2.78000  13.64800  1.000 66.76000  ? 21  LEU A H      1 
ATOM   227  H HA     . LEU A 1 21  ? 7.85200  -4.77300  15.19800  1.000 70.90000  ? 21  LEU A HA     1 
ATOM   228  H HB2    . LEU A 1 21  ? 6.49400  -3.90300  13.54500  1.000 71.00000  ? 21  LEU A HB2    1 
ATOM   229  H HB3    . LEU A 1 21  ? 7.54400  -4.25100  12.41400  1.000 71.00000  ? 21  LEU A HB3    1 
ATOM   230  H HG     . LEU A 1 21  ? 6.35900  -6.42400  13.77100  1.000 81.63000  ? 21  LEU A HG     1 
ATOM   231  H HD11   . LEU A 1 21  ? 4.55600  -5.00600  13.25800  1.000 64.79000  ? 21  LEU A HD11   1 
ATOM   232  H HD12   . LEU A 1 21  ? 4.98900  -4.99800  11.73100  1.000 64.79000  ? 21  LEU A HD12   1 
ATOM   233  H HD13   . LEU A 1 21  ? 4.46700  -6.33900  12.40100  1.000 64.79000  ? 21  LEU A HD13   1 
ATOM   234  H HD21   . LEU A 1 21  ? 7.56900  -6.07200  11.28700  1.000 82.46000  ? 21  LEU A HD21   1 
ATOM   235  H HD22   . LEU A 1 21  ? 7.64200  -7.33600  12.24200  1.000 82.46000  ? 21  LEU A HD22   1 
ATOM   236  H HD23   . LEU A 1 21  ? 6.37400  -7.11200  11.31500  1.000 82.46000  ? 21  LEU A HD23   1 
ATOM   237  N N      . ILE A 1 22  ? 9.93800  -5.73500  12.89100  1.000 61.90000  ? 22  ILE A N      1 
ATOM   238  C CA     . ILE A 1 22  ? 10.82400 -6.85200  12.44700  1.000 51.74000  ? 22  ILE A CA     1 
ATOM   239  C C      . ILE A 1 22  ? 12.02500 -6.99900  13.38600  1.000 57.76000  ? 22  ILE A C      1 
ATOM   240  O O      . ILE A 1 22  ? 12.37400 -8.15300  13.68300  1.000 51.66000  ? 22  ILE A O      1 
ATOM   241  C CB     . ILE A 1 22  ? 11.29600 -6.65200  10.99400  1.000 58.82000  ? 22  ILE A CB     1 
ATOM   242  C CG1    . ILE A 1 22  ? 10.13400 -6.52600  10.00500  1.000 51.07000  ? 22  ILE A CG1    1 
ATOM   243  C CG2    . ILE A 1 22  ? 12.26000 -7.76600  10.58000  1.000 52.19000  ? 22  ILE A CG2    1 
ATOM   244  C CD1    . ILE A 1 22  ? 9.36200  -7.81000  9.77200   1.000 53.15000  ? 22  ILE A CD1    1 
ATOM   245  H H      . ILE A 1 22  ? 9.91800  -5.01200  12.35300  1.000 74.66000  ? 22  ILE A H      1 
ATOM   246  H HA     . ILE A 1 22  ? 10.30700 -7.67600  12.48200  1.000 62.47000  ? 22  ILE A HA     1 
ATOM   247  H HB     . ILE A 1 22  ? 11.79200 -5.81000  10.96700  1.000 70.97000  ? 22  ILE A HB     1 
ATOM   248  H HG12   . ILE A 1 22  ? 9.51300  -5.84500  10.33100  1.000 61.66000  ? 22  ILE A HG12   1 
ATOM   249  H HG13   . ILE A 1 22  ? 10.49000 -6.21600  9.14800   1.000 61.66000  ? 22  ILE A HG13   1 
ATOM   250  H HG21   . ILE A 1 22  ? 12.22800 -7.88400  9.61700   1.000 63.01000  ? 22  ILE A HG21   1 
ATOM   251  H HG22   . ILE A 1 22  ? 13.16500 -7.53200  10.84400  1.000 63.01000  ? 22  ILE A HG22   1 
ATOM   252  H HG23   . ILE A 1 22  ? 12.00400 -8.59800  11.01300  1.000 63.01000  ? 22  ILE A HG23   1 
ATOM   253  H HD11   . ILE A 1 22  ? 8.44900  -7.59100  9.50300   1.000 64.16000  ? 22  ILE A HD11   1 
ATOM   254  H HD12   . ILE A 1 22  ? 9.79200  -8.32600  9.06400   1.000 64.16000  ? 22  ILE A HD12   1 
ATOM   255  H HD13   . ILE A 1 22  ? 9.34000  -8.33900  10.59100  1.000 64.16000  ? 22  ILE A HD13   1 
ATOM   256  N N      . ILE A 1 23  ? 12.65300 -5.90800  13.83400  1.000 62.27000  ? 23  ILE A N      1 
ATOM   257  C CA     . ILE A 1 23  ? 13.86800 -6.05300  14.62700  1.000 65.97000  ? 23  ILE A CA     1 
ATOM   258  C C      . ILE A 1 23  ? 13.57400 -6.64200  15.98600  1.000 71.51000  ? 23  ILE A C      1 
ATOM   259  O O      . ILE A 1 23  ? 14.50300 -7.04000  16.69500  1.000 82.10000  ? 23  ILE A O      1 
ATOM   260  C CB     . ILE A 1 23  ? 14.59500 -4.70100  14.74700  1.000 64.97000  ? 23  ILE A CB     1 
ATOM   261  C CG1    . ILE A 1 23  ? 15.93300 -4.88400  15.44300  1.000 57.58000  ? 23  ILE A CG1    1 
ATOM   262  C CG2    . ILE A 1 23  ? 13.76600 -3.72500  15.50400  1.000 68.91000  ? 23  ILE A CG2    1 
ATOM   263  C CD1    . ILE A 1 23  ? 16.95600 -3.88200  15.01800  1.000 68.91000  ? 23  ILE A CD1    1 
ATOM   264  H H      . ILE A 1 23  ? 12.42800 -5.10000  13.64400  1.000 75.10000  ? 23  ILE A H      1 
ATOM   265  H HA     . ILE A 1 23  ? 14.47800 -6.65600  14.17400  1.000 79.54000  ? 23  ILE A HA     1 
ATOM   266  H HB     . ILE A 1 23  ? 14.74500 -4.35900  13.85200  1.000 78.35000  ? 23  ILE A HB     1 
ATOM   267  H HG12   . ILE A 1 23  ? 15.80500 -4.79300  16.40000  1.000 69.47000  ? 23  ILE A HG12   1 
ATOM   268  H HG13   . ILE A 1 23  ? 16.27600 -5.76700  15.23700  1.000 69.47000  ? 23  ILE A HG13   1 
ATOM   269  H HG21   . ILE A 1 23  ? 14.11100 -2.83200  15.35100  1.000 83.08000  ? 23  ILE A HG21   1 
ATOM   270  H HG22   . ILE A 1 23  ? 12.84900 -3.78300  15.19300  1.000 83.08000  ? 23  ILE A HG22   1 
ATOM   271  H HG23   . ILE A 1 23  ? 13.81000 -3.94000  16.44900  1.000 83.08000  ? 23  ILE A HG23   1 
ATOM   272  H HD11   . ILE A 1 23  ? 17.72800 -3.95200  15.60100  1.000 83.08000  ? 23  ILE A HD11   1 
ATOM   273  H HD12   . ILE A 1 23  ? 17.21500 -4.06500  14.10100  1.000 83.08000  ? 23  ILE A HD12   1 
ATOM   274  H HD13   . ILE A 1 23  ? 16.57200 -2.99300  15.08200  1.000 83.08000  ? 23  ILE A HD13   1 
ATOM   275  N N      . ASN A 1 24  ? 12.29800 -6.75200  16.33900  1.000 76.55000  ? 24  ASN A N      1 
ATOM   276  C CA     . ASN A 1 24  ? 11.91100 -7.26000  17.64000  1.000 82.87000  ? 24  ASN A CA     1 
ATOM   277  C C      . ASN A 1 24  ? 11.25200 -8.63000  17.60900  1.000 78.20000  ? 24  ASN A C      1 
ATOM   278  O O      . ASN A 1 24  ? 11.25100 -9.30700  18.64500  1.000 70.07000  ? 24  ASN A O      1 
ATOM   279  C CB     . ASN A 1 24  ? 10.95600 -6.26900  18.34400  1.000 62.23000  ? 24  ASN A CB     1 
ATOM   280  C CG     . ASN A 1 24  ? 11.65400 -5.04000  18.81800  1.000 51.73000  ? 24  ASN A CG     1 
ATOM   281  O OD1    . ASN A 1 24  ? 11.26200 -3.90200  18.51200  1.000 57.44000  ? 24  ASN A OD1    1 
ATOM   282  N ND2    . ASN A 1 24  ? 12.72800 -5.25100  19.54700  1.000 52.80000  ? 24  ASN A ND2    1 
ATOM   283  H H      . ASN A 1 24  ? 11.63500 -6.53500  15.83500  1.000 92.24000  ? 24  ASN A H      1 
ATOM   284  H HA     . ASN A 1 24  ? 12.71300 -7.34000  18.18000  1.000 99.83000  ? 24  ASN A HA     1 
ATOM   285  H HB2    . ASN A 1 24  ? 10.26300 -5.99900  17.72000  1.000 75.05000  ? 24  ASN A HB2    1 
ATOM   286  H HB3    . ASN A 1 24  ? 10.55800 -6.70400  19.11400  1.000 75.05000  ? 24  ASN A HB3    1 
ATOM   287  H HD21   . ASN A 1 24  ? 13.17800 -4.58500  19.85200  1.000 63.74000  ? 24  ASN A HD21   1 
ATOM   288  H HD22   . ASN A 1 24  ? 12.98000 -6.05500  19.71800  1.000 63.74000  ? 24  ASN A HD22   1 
ATOM   289  N N      . THR A 1 25  ? 10.59900 -8.95500  16.49500  1.000 70.06000  ? 25  THR A N      1 
ATOM   290  C CA     . THR A 1 25  ? 9.79100  -10.17100 16.36600  1.000 56.37000  ? 25  THR A CA     1 
ATOM   291  C C      . THR A 1 25  ? 10.53000 -11.37700 16.81400  1.000 75.16000  ? 25  THR A C      1 
ATOM   292  O O      . THR A 1 25  ? 11.73000 -11.48400 16.52200  1.000 72.86000  ? 25  THR A O      1 
ATOM   293  C CB     . THR A 1 25  ? 9.35700  -10.38000 14.92000  1.000 73.81000  ? 25  THR A CB     1 
ATOM   294  O OG1    . THR A 1 25  ? 10.52700 -10.19000 14.13500  1.000 109.51000 ? 25  THR A OG1    1 
ATOM   295  C CG2    . THR A 1 25  ? 8.28600  -9.40700  14.46500  1.000 73.32000  ? 25  THR A CG2    1 
ATOM   296  H H      . THR A 1 25  ? 10.61400 -8.46900  15.73300  1.000 84.45000  ? 25  THR A H      1 
ATOM   297  H HA     . THR A 1 25  ? 8.98900  -10.06700 16.92000  1.000 68.03000  ? 25  THR A HA     1 
ATOM   298  H HB     . THR A 1 25  ? 9.03100  -11.30500 14.80700  1.000 88.95000  ? 25  THR A HB     1 
ATOM   299  H HG1    . THR A 1 25  ? 10.89700 -10.95000 13.95700  1.000 131.79000 ? 25  THR A HG1    1 
ATOM   300  H HG21   . THR A 1 25  ? 7.51500  -9.90100  14.14200  1.000 88.37000  ? 25  THR A HG21   1 
ATOM   301  H HG22   . THR A 1 25  ? 8.02000  -8.84600  15.21100  1.000 88.37000  ? 25  THR A HG22   1 
ATOM   302  H HG23   . THR A 1 25  ? 8.63700  -8.85200  13.74800  1.000 88.37000  ? 25  THR A HG23   1 
ATOM   303  N N      . VAL A 1 26  ? 9.83800  -12.23600 17.53500  1.000 67.81000  ? 26  VAL A N      1 
ATOM   304  C CA     . VAL A 1 26  ? 10.38900 -13.56000 17.88300  1.000 89.31000  ? 26  VAL A CA     1 
ATOM   305  C C      . VAL A 1 26  ? 9.88300  -14.41700 16.72200  1.000 79.40000  ? 26  VAL A C      1 
ATOM   306  O O      . VAL A 1 26  ? 8.66300  -14.44000 16.50500  1.000 91.63000  ? 26  VAL A O      1 
ATOM   307  C CB     . VAL A 1 26  ? 9.93700  -14.04800 19.27200  1.000 72.90000  ? 26  VAL A CB     1 
ATOM   308  C CG1    . VAL A 1 26  ? 10.39700 -13.08700 20.35400  1.000 72.31000  ? 26  VAL A CG1    1 
ATOM   309  C CG2    . VAL A 1 26  ? 8.43700  -14.27600 19.39000  1.000 58.28000  ? 26  VAL A CG2    1 
ATOM   310  H H      . VAL A 1 26  ? 9.00800  -12.04700 17.83200  1.000 81.76000  ? 26  VAL A H      1 
ATOM   311  H HA     . VAL A 1 26  ? 11.36200 -13.52700 17.85900  1.000 107.56000 ? 26  VAL A HA     1 
ATOM   312  H HB     . VAL A 1 26  ? 10.38200 -14.91100 19.43100  1.000 87.86000  ? 26  VAL A HB     1 
ATOM   313  H HG11   . VAL A 1 26  ? 10.49000 -13.56400 21.19500  1.000 87.16000  ? 26  VAL A HG11   1 
ATOM   314  H HG12   . VAL A 1 26  ? 11.25300 -12.70200 20.10200  1.000 87.16000  ? 26  VAL A HG12   1 
ATOM   315  H HG13   . VAL A 1 26  ? 9.74100  -12.37700 20.45500  1.000 87.16000  ? 26  VAL A HG13   1 
ATOM   316  H HG21   . VAL A 1 26  ? 8.18200  -14.24800 20.32700  1.000 70.32000  ? 26  VAL A HG21   1 
ATOM   317  H HG22   . VAL A 1 26  ? 7.96000  -13.58200 18.90700  1.000 70.32000  ? 26  VAL A HG22   1 
ATOM   318  H HG23   . VAL A 1 26  ? 8.20900  -15.14500 19.02100  1.000 70.32000  ? 26  VAL A HG23   1 
ATOM   319  N N      . TYR A 1 27  ? 10.77400 -14.94000 15.90100  1.000 57.67000  ? 27  TYR A N      1 
ATOM   320  C CA     . TYR A 1 27  ? 10.36100 -15.74100 14.72800  1.000 51.13000  ? 27  TYR A CA     1 
ATOM   321  C C      . TYR A 1 27  ? 11.34700 -16.84900 14.64000  1.000 58.65000  ? 27  TYR A C      1 
ATOM   322  O O      . TYR A 1 27  ? 12.52000 -16.61000 14.93900  1.000 55.69000  ? 27  TYR A O      1 
ATOM   323  C CB     . TYR A 1 27  ? 10.24400 -14.85300 13.49200  1.000 69.80000  ? 27  TYR A CB     1 
ATOM   324  C CG     . TYR A 1 27  ? 9.87800  -15.60200 12.22300  1.000 68.56000  ? 27  TYR A CG     1 
ATOM   325  C CD1    . TYR A 1 27  ? 8.67700  -16.28600 12.12200  1.000 55.97000  ? 27  TYR A CD1    1 
ATOM   326  C CD2    . TYR A 1 27  ? 10.73500 -15.63000 11.13400  1.000 57.37000  ? 27  TYR A CD2    1 
ATOM   327  C CE1    . TYR A 1 27  ? 8.33700  -16.97700 10.97500  1.000 52.35000  ? 27  TYR A CE1    1 
ATOM   328  C CE2    . TYR A 1 27  ? 10.40400 -16.31400 9.98000   1.000 64.34000  ? 27  TYR A CE2    1 
ATOM   329  C CZ     . TYR A 1 27  ? 9.20500  -16.99100 9.90200   1.000 61.64000  ? 27  TYR A CZ     1 
ATOM   330  O OH     . TYR A 1 27  ? 8.89700  -17.66400 8.76300   1.000 61.35000  ? 27  TYR A OH     1 
ATOM   331  H H      . TYR A 1 27  ? 11.66000 -14.82000 16.02100  1.000 69.58000  ? 27  TYR A H      1 
ATOM   332  H HA     . TYR A 1 27  ? 9.47200  -16.13900 14.91100  1.000 61.74000  ? 27  TYR A HA     1 
ATOM   333  H HB2    . TYR A 1 27  ? 9.56200  -14.16600 13.66400  1.000 84.14000  ? 27  TYR A HB2    1 
ATOM   334  H HB3    . TYR A 1 27  ? 11.10400 -14.39700 13.35500  1.000 84.14000  ? 27  TYR A HB3    1 
ATOM   335  H HD1    . TYR A 1 27  ? 8.08400  -16.28800 12.85500  1.000 67.54000  ? 27  TYR A HD1    1 
ATOM   336  H HD2    . TYR A 1 27  ? 11.55700 -15.16700 11.17800  1.000 69.22000  ? 27  TYR A HD2    1 
ATOM   337  H HE1    . TYR A 1 27  ? 7.52200  -17.44100 10.93000  1.000 63.20000  ? 27  TYR A HE1    1 
ATOM   338  H HE2    . TYR A 1 27  ? 10.98900 -16.31500 9.24700   1.000 77.58000  ? 27  TYR A HE2    1 
ATOM   339  H HH     . TYR A 1 27  ? 8.26600  -17.25400 8.35500   1.000 74.01000  ? 27  TYR A HH     1 
ATOM   340  N N      . SER A 1 28  ? 10.88700 -18.02500 14.25500  1.000 56.97000  ? 28  SER A N      1 
ATOM   341  C CA     . SER A 1 28  ? 11.73500 -19.23200 14.26400  1.000 80.38000  ? 28  SER A CA     1 
ATOM   342  C C      . SER A 1 28  ? 12.58900 -19.33500 12.99900  1.000 84.07000  ? 28  SER A C      1 
ATOM   343  O O      . SER A 1 28  ? 13.78200 -19.64500 13.15300  1.000 94.62000  ? 28  SER A O      1 
ATOM   344  C CB     . SER A 1 28  ? 10.87100 -20.44600 14.43800  1.000 70.01000  ? 28  SER A CB     1 
ATOM   345  O OG     . SER A 1 28  ? 9.58400  -20.23800 13.87400  1.000 78.04000  ? 28  SER A OG     1 
ATOM   346  H H      . SER A 1 28  ? 10.04100 -18.13000 13.96100  1.000 68.75000  ? 28  SER A H      1 
ATOM   347  H HA     . SER A 1 28  ? 12.34500 -19.17500 15.04100  1.000 96.83000  ? 28  SER A HA     1 
ATOM   348  H HB2    . SER A 1 28  ? 11.29700 -21.20900 14.00300  1.000 84.40000  ? 28  SER A HB2    1 
ATOM   349  H HB3    . SER A 1 28  ? 10.78100 -20.64600 15.38800  1.000 84.40000  ? 28  SER A HB3    1 
ATOM   350  H HG     . SER A 1 28  ? 9.66400  -20.16500 13.03400  1.000 94.03000  ? 28  SER A HG     1 
ATOM   351  N N      . ASN A 1 29  ? 12.02300 -19.08900 11.82400  1.000 57.93000  ? 29  ASN A N      1 
ATOM   352  C CA     . ASN A 1 29  ? 12.75900 -19.29300 10.55400  1.000 61.68000  ? 29  ASN A CA     1 
ATOM   353  C C      . ASN A 1 29  ? 13.38600 -17.96800 10.10000  1.000 61.15000  ? 29  ASN A C      1 
ATOM   354  O O      . ASN A 1 29  ? 13.10500 -17.56200 8.97800   1.000 50.73000  ? 29  ASN A O      1 
ATOM   355  C CB     . ASN A 1 29  ? 11.83900 -19.97100 9.54300   1.000 59.83000  ? 29  ASN A CB     1 
ATOM   356  C CG     . ASN A 1 29  ? 12.57800 -20.90300 8.61700   1.000 81.14000  ? 29  ASN A CG     1 
ATOM   357  O OD1    . ASN A 1 29  ? 13.23300 -21.84700 9.06800   1.000 64.43000  ? 29  ASN A OD1    1 
ATOM   358  N ND2    . ASN A 1 29  ? 12.47300 -20.66900 7.31900   1.000 78.91000  ? 29  ASN A ND2    1 
ATOM   359  H H      . ASN A 1 29  ? 11.17700 -18.78200 11.76100  1.000 69.90000  ? 29  ASN A H      1 
ATOM   360  H HA     . ASN A 1 29  ? 13.49400 -19.91600 10.72700  1.000 74.40000  ? 29  ASN A HA     1 
ATOM   361  H HB2    . ASN A 1 29  ? 11.16300 -20.48200 10.03000  1.000 72.18000  ? 29  ASN A HB2    1 
ATOM   362  H HB3    . ASN A 1 29  ? 11.37300 -19.29300 9.01500   1.000 72.18000  ? 29  ASN A HB3    1 
ATOM   363  H HD21   . ASN A 1 29  ? 11.69000 -20.44000 6.97500   1.000 95.07000  ? 29  ASN A HD21   1 
ATOM   364  H HD22   . ASN A 1 29  ? 13.19100 -20.72800 6.79800   1.000 95.07000  ? 29  ASN A HD22   1 
ATOM   365  N N      . LYS A 1 30  ? 14.25500 -17.35500 10.90700  1.000 40.61000  ? 30  LYS A N      1 
ATOM   366  C CA     . LYS A 1 30  ? 14.89700 -16.10400 10.52800  1.000 55.54000  ? 30  LYS A CA     1 
ATOM   367  C C      . LYS A 1 30  ? 15.79100 -16.23500 9.29200   1.000 55.32000  ? 30  LYS A C      1 
ATOM   368  O O      . LYS A 1 30  ? 16.10500 -15.23200 8.65400   1.000 41.11000  ? 30  LYS A O      1 
ATOM   369  C CB     . LYS A 1 30  ? 15.65800 -15.58500 11.74800  1.000 53.38000  ? 30  LYS A CB     1 
ATOM   370  C CG     . LYS A 1 30  ? 14.75500 -14.95700 12.82200  1.000 61.36000  ? 30  LYS A CG     1 
ATOM   371  C CD     . LYS A 1 30  ? 15.51700 -14.54200 14.12700  1.000 56.88000  ? 30  LYS A CD     1 
ATOM   372  C CE     . LYS A 1 30  ? 14.66000 -13.55400 14.99600  1.000 60.84000  ? 30  LYS A CE     1 
ATOM   373  N NZ     . LYS A 1 30  ? 15.24700 -13.16400 16.30600  1.000 64.49000  ? 30  LYS A NZ     1 
ATOM   374  H H      . LYS A 1 30  ? 14.48800 -17.64000 11.68500  1.000 49.12000  ? 30  LYS A H      1 
ATOM   375  H HA     . LYS A 1 30  ? 14.23400 -15.44100 10.27900  1.000 67.03000  ? 30  LYS A HA     1 
ATOM   376  H HB2    . LYS A 1 30  ? 16.13300 -16.32500 12.15700  1.000 64.44000  ? 30  LYS A HB2    1 
ATOM   377  H HB3    . LYS A 1 30  ? 16.28800 -14.90700 11.45700  1.000 64.44000  ? 30  LYS A HB3    1 
ATOM   378  H HG2    . LYS A 1 30  ? 14.34300 -14.15900 12.45500  1.000 74.01000  ? 30  LYS A HG2    1 
ATOM   379  H HG3    . LYS A 1 30  ? 14.07200 -15.59900 13.07000  1.000 74.01000  ? 30  LYS A HG3    1 
ATOM   380  H HD2    . LYS A 1 30  ? 15.70300 -15.33300 14.65700  1.000 68.64000  ? 30  LYS A HD2    1 
ATOM   381  H HD3    . LYS A 1 30  ? 16.34700 -14.10000 13.88900  1.000 68.64000  ? 30  LYS A HD3    1 
ATOM   382  H HE2    . LYS A 1 30  ? 14.52800 -12.73800 14.48800  1.000 73.39000  ? 30  LYS A HE2    1 
ATOM   383  H HE3    . LYS A 1 30  ? 13.80500 -13.97300 15.17900  1.000 73.39000  ? 30  LYS A HE3    1 
ATOM   384  H HZ1    . LYS A 1 30  ? 14.73900 -12.54500 16.69500  1.000 77.77000  ? 30  LYS A HZ1    1 
ATOM   385  H HZ2    . LYS A 1 30  ? 15.29600 -13.87400 16.84100  1.000 77.77000  ? 30  LYS A HZ2    1 
ATOM   386  H HZ3    . LYS A 1 30  ? 16.06500 -12.83500 16.18800  1.000 77.77000  ? 30  LYS A HZ3    1 
ATOM   387  N N      . GLU A 1 31  ? 16.13200 -17.44300 8.88600   1.000 47.15000  ? 31  GLU A N      1 
ATOM   388  C CA     . GLU A 1 31  ? 16.97100 -17.63500 7.71600   1.000 49.81000  ? 31  GLU A CA     1 
ATOM   389  C C      . GLU A 1 31  ? 16.30900 -17.19700 6.41600   1.000 56.45000  ? 31  GLU A C      1 
ATOM   390  O O      . GLU A 1 31  ? 16.97100 -17.16100 5.37300   1.000 40.43000  ? 31  GLU A O      1 
ATOM   391  C CB     . GLU A 1 31  ? 17.35800 -19.11100 7.57900   1.000 51.68000  ? 31  GLU A CB     1 
ATOM   392  C CG     . GLU A 1 31  ? 16.26100 -19.97800 6.98200   1.000 66.43000  ? 31  GLU A CG     1 
ATOM   393  C CD     . GLU A 1 31  ? 16.35000 -21.44300 7.41000   1.000 70.13000  ? 31  GLU A CD     1 
ATOM   394  O OE1    . GLU A 1 31  ? 16.27200 -21.73000 8.63800   1.000 68.14000  ? 31  GLU A OE1    1 
ATOM   395  O OE2    . GLU A 1 31  ? 16.51800 -22.29200 6.51100   1.000 64.08000  ? 31  GLU A OE2    1 
ATOM   396  H H      . GLU A 1 31  ? 15.89000 -18.17300 9.27100   1.000 56.97000  ? 31  GLU A H      1 
ATOM   397  H HA     . GLU A 1 31  ? 17.77300 -17.10500 7.84600   1.000 60.15000  ? 31  GLU A HA     1 
ATOM   398  H HB2    . GLU A 1 31  ? 18.13500 -19.17700 7.00200   1.000 62.40000  ? 31  GLU A HB2    1 
ATOM   399  H HB3    . GLU A 1 31  ? 17.56800 -19.46100 8.45900   1.000 62.40000  ? 31  GLU A HB3    1 
ATOM   400  H HG2    . GLU A 1 31  ? 15.40000 -19.63600 7.26800   1.000 80.09000  ? 31  GLU A HG2    1 
ATOM   401  H HG3    . GLU A 1 31  ? 16.32600 -19.94500 6.01500   1.000 80.09000  ? 31  GLU A HG3    1 
ATOM   402  N N      . ILE A 1 32  ? 15.01700 -16.89000 6.41600   1.000 44.27000  ? 32  ILE A N      1 
ATOM   403  C CA     . ILE A 1 32  ? 14.42000 -16.49200 5.15300   1.000 41.50000  ? 32  ILE A CA     1 
ATOM   404  C C      . ILE A 1 32  ? 14.86200 -15.09400 4.72600   1.000 47.30000  ? 32  ILE A C      1 
ATOM   405  O O      . ILE A 1 32  ? 14.58300 -14.69100 3.58000   1.000 43.38000  ? 32  ILE A O      1 
ATOM   406  C CB     . ILE A 1 32  ? 12.87900 -16.57900 5.20700   1.000 54.87000  ? 32  ILE A CB     1 
ATOM   407  C CG1    . ILE A 1 32  ? 12.30500 -15.71100 6.32500   1.000 48.03000  ? 32  ILE A CG1    1 
ATOM   408  C CG2    . ILE A 1 32  ? 12.43700 -18.02600 5.39300   1.000 62.09000  ? 32  ILE A CG2    1 
ATOM   409  C CD1    . ILE A 1 32  ? 11.81500 -14.36200 5.82100   1.000 54.67000  ? 32  ILE A CD1    1 
ATOM   410  H H      . ILE A 1 32  ? 14.49400 -16.90500 7.09900   1.000 53.51000  ? 32  ILE A H      1 
ATOM   411  H HA     . ILE A 1 32  ? 14.71200 -17.11800 4.47100   1.000 50.18000  ? 32  ILE A HA     1 
ATOM   412  H HB     . ILE A 1 32  ? 12.53800 -16.24400 4.36300   1.000 66.23000  ? 32  ILE A HB     1 
ATOM   413  H HG12   . ILE A 1 32  ? 11.55500 -16.17200 6.73100   1.000 58.02000  ? 32  ILE A HG12   1 
ATOM   414  H HG13   . ILE A 1 32  ? 12.99500 -15.55200 6.98800   1.000 58.02000  ? 32  ILE A HG13   1 
ATOM   415  H HG21   . ILE A 1 32  ? 11.46800 -18.06100 5.41400   1.000 74.88000  ? 32  ILE A HG21   1 
ATOM   416  H HG22   . ILE A 1 32  ? 12.77000 -18.55600 4.65200   1.000 74.88000  ? 32  ILE A HG22   1 
ATOM   417  H HG23   . ILE A 1 32  ? 12.79900 -18.36200 6.22800   1.000 74.88000  ? 32  ILE A HG23   1 
ATOM   418  H HD11   . ILE A 1 32  ? 11.42000 -13.87400 6.56000   1.000 65.99000  ? 32  ILE A HD11   1 
ATOM   419  H HD12   . ILE A 1 32  ? 12.56800 -13.86700 5.46200   1.000 65.99000  ? 32  ILE A HD12   1 
ATOM   420  H HD13   . ILE A 1 32  ? 11.15200 -14.50600 5.12800   1.000 65.99000  ? 32  ILE A HD13   1 
ATOM   421  N N      . PHE A 1 33  ? 15.52500 -14.32700 5.61100   1.000 41.58000  ? 33  PHE A N      1 
ATOM   422  C CA     . PHE A 1 33  ? 16.04600 -13.03800 5.17700   1.000 45.90000  ? 33  PHE A CA     1 
ATOM   423  C C      . PHE A 1 33  ? 16.94700 -13.24000 3.96600   1.000 44.50000  ? 33  PHE A C      1 
ATOM   424  O O      . PHE A 1 33  ? 16.98600 -12.41200 3.05400   1.000 34.58000  ? 33  PHE A O      1 
ATOM   425  C CB     . PHE A 1 33  ? 16.80400 -12.32800 6.33400   1.000 43.97000  ? 33  PHE A CB     1 
ATOM   426  C CG     . PHE A 1 33  ? 18.21000 -12.80600 6.51200   1.000 38.26000  ? 33  PHE A CG     1 
ATOM   427  C CD1    . PHE A 1 33  ? 18.48500 -13.92000 7.33100   1.000 42.43000  ? 33  PHE A CD1    1 
ATOM   428  C CD2    . PHE A 1 33  ? 19.27400 -12.17000 5.86400   1.000 42.46000  ? 33  PHE A CD2    1 
ATOM   429  C CE1    . PHE A 1 33  ? 19.78800 -14.40600 7.47000   1.000 42.47000  ? 33  PHE A CE1    1 
ATOM   430  C CE2    . PHE A 1 33  ? 20.61500 -12.67900 5.99600   1.000 36.31000  ? 33  PHE A CE2    1 
ATOM   431  C CZ     . PHE A 1 33  ? 20.85800 -13.78400 6.80300   1.000 35.44000  ? 33  PHE A CZ     1 
ATOM   432  H H      . PHE A 1 33  ? 15.67700 -14.52900 6.43300   1.000 50.28000  ? 33  PHE A H      1 
ATOM   433  H HA     . PHE A 1 33  ? 15.31600 -12.44700 4.93500   1.000 55.46000  ? 33  PHE A HA     1 
ATOM   434  H HB2    . PHE A 1 33  ? 16.83500 -11.37600 6.14900   1.000 53.14000  ? 33  PHE A HB2    1 
ATOM   435  H HB3    . PHE A 1 33  ? 16.32800 -12.48900 7.16400   1.000 53.14000  ? 33  PHE A HB3    1 
ATOM   436  H HD1    . PHE A 1 33  ? 17.79000 -14.33800 7.78500   1.000 51.30000  ? 33  PHE A HD1    1 
ATOM   437  H HD2    . PHE A 1 33  ? 19.11500 -11.41500 5.34500   1.000 51.33000  ? 33  PHE A HD2    1 
ATOM   438  H HE1    . PHE A 1 33  ? 19.94900 -15.14800 8.00700   1.000 51.35000  ? 33  PHE A HE1    1 
ATOM   439  H HE2    . PHE A 1 33  ? 21.31700 -12.27000 5.54300   1.000 43.96000  ? 33  PHE A HE2    1 
ATOM   440  H HZ     . PHE A 1 33  ? 21.72300 -14.11000 6.90200   1.000 42.91000  ? 33  PHE A HZ     1 
ATOM   441  N N      . LEU A 1 34  ? 17.67700 -14.34200 3.92900   1.000 36.62000  ? 34  LEU A N      1 
ATOM   442  C CA     . LEU A 1 34  ? 18.66500 -14.50700 2.86900   1.000 41.98000  ? 34  LEU A CA     1 
ATOM   443  C C      . LEU A 1 34  ? 18.00800 -14.70500 1.51300   1.000 42.16000  ? 34  LEU A C      1 
ATOM   444  O O      . LEU A 1 34  ? 18.48700 -14.16200 0.50200   1.000 31.57000  ? 34  LEU A O      1 
ATOM   445  C CB     . LEU A 1 34  ? 19.60100 -15.67900 3.19400   1.000 40.54000  ? 34  LEU A CB     1 
ATOM   446  C CG     . LEU A 1 34  ? 20.75400 -15.73500 2.19500   1.000 43.87000  ? 34  LEU A CG     1 
ATOM   447  C CD1    . LEU A 1 34  ? 21.41800 -14.37800 2.09200   1.000 50.38000  ? 34  LEU A CD1    1 
ATOM   448  C CD2    . LEU A 1 34  ? 21.79100 -16.75900 2.55000   1.000 31.98000  ? 34  LEU A CD2    1 
ATOM   449  H H      . LEU A 1 34  ? 17.62400 -14.99400 4.48800   1.000 44.33000  ? 34  LEU A H      1 
ATOM   450  H HA     . LEU A 1 34  ? 19.20100 -13.70000 2.82200   1.000 50.76000  ? 34  LEU A HA     1 
ATOM   451  H HB2    . LEU A 1 34  ? 19.96700 -15.56300 4.08400   1.000 49.02000  ? 34  LEU A HB2    1 
ATOM   452  H HB3    . LEU A 1 34  ? 19.10600 -16.51200 3.14400   1.000 49.02000  ? 34  LEU A HB3    1 
ATOM   453  H HG     . LEU A 1 34  ? 20.37500 -15.99400 1.34100   1.000 53.02000  ? 34  LEU A HG     1 
ATOM   454  H HD11   . LEU A 1 34  ? 22.26600 -14.47600 1.63200   1.000 60.83000  ? 34  LEU A HD11   1 
ATOM   455  H HD12   . LEU A 1 34  ? 20.83900 -13.78000 1.59400   1.000 60.83000  ? 34  LEU A HD12   1 
ATOM   456  H HD13   . LEU A 1 34  ? 21.56400 -14.02900 2.98500   1.000 60.83000  ? 34  LEU A HD13   1 
ATOM   457  H HD21   . LEU A 1 34  ? 22.45800 -16.78900 1.84600   1.000 38.76000  ? 34  LEU A HD21   1 
ATOM   458  H HD22   . LEU A 1 34  ? 22.20800 -16.50800 3.39000   1.000 38.76000  ? 34  LEU A HD22   1 
ATOM   459  H HD23   . LEU A 1 34  ? 21.36300 -17.62400 2.63900   1.000 38.76000  ? 34  LEU A HD23   1 
ATOM   460  N N      . ARG A 1 35  ? 16.92200 -15.49200 1.46100   1.000 38.25000  ? 35  ARG A N      1 
ATOM   461  C CA     . ARG A 1 35  ? 16.12600 -15.58400 0.22500   1.000 36.66000  ? 35  ARG A CA     1 
ATOM   462  C C      . ARG A 1 35  ? 15.65300 -14.20100 -0.23300  1.000 35.08000  ? 35  ARG A C      1 
ATOM   463  O O      . ARG A 1 35  ? 15.74000 -13.85800 -1.41300  1.000 40.39000  ? 35  ARG A O      1 
ATOM   464  C CB     . ARG A 1 35  ? 14.90600 -16.51000 0.42500   1.000 59.77000  ? 35  ARG A CB     1 
ATOM   465  C CG     . ARG A 1 35  ? 14.21100 -16.90600 -0.87800  1.000 80.32000  ? 35  ARG A CG     1 
ATOM   466  C CD     . ARG A 1 35  ? 12.69500 -16.81200 -0.78800  1.000 68.79000  ? 35  ARG A CD     1 
ATOM   467  N NE     . ARG A 1 35  ? 12.08100 -17.93300 -0.10600  1.000 76.32000  ? 35  ARG A NE     1 
ATOM   468  C CZ     . ARG A 1 35  ? 11.05600 -17.83400 0.72400   1.000 79.69000  ? 35  ARG A CZ     1 
ATOM   469  N NH1    . ARG A 1 35  ? 10.57000 -16.65600 1.10600   1.000 67.86000  ? 35  ARG A NH1    1 
ATOM   470  N NH2    . ARG A 1 35  ? 10.55300 -18.94100 1.24200   1.000 75.60000  ? 35  ARG A NH2    1 
ATOM   471  H H      . ARG A 1 35  ? 16.63000 -15.97300 2.11200   1.000 46.28000  ? 35  ARG A H      1 
ATOM   472  H HA     . ARG A 1 35  ? 16.68900 -15.97000 -0.46500  1.000 44.38000  ? 35  ARG A HA     1 
ATOM   473  H HB2    . ARG A 1 35  ? 15.20000 -17.32400 0.86200   1.000 72.11000  ? 35  ARG A HB2    1 
ATOM   474  H HB3    . ARG A 1 35  ? 14.25500 -16.05200 0.98000   1.000 72.11000  ? 35  ARG A HB3    1 
ATOM   475  H HG2    . ARG A 1 35  ? 14.50600 -16.31300 -1.58700  1.000 96.77000  ? 35  ARG A HG2    1 
ATOM   476  H HG3    . ARG A 1 35  ? 14.44200 -17.82300 -1.09400  1.000 96.77000  ? 35  ARG A HG3    1 
ATOM   477  H HD2    . ARG A 1 35  ? 12.46000 -16.00600 -0.30200  1.000 82.93000  ? 35  ARG A HD2    1 
ATOM   478  H HD3    . ARG A 1 35  ? 12.33000 -16.77700 -1.68600  1.000 82.93000  ? 35  ARG A HD3    1 
ATOM   479  H HE     . ARG A 1 35  ? 12.40500 -18.71700 -0.25000  1.000 91.96000  ? 35  ARG A HE     1 
ATOM   480  H HH11   . ARG A 1 35  ? 10.92300 -15.93000 0.81200   1.000 81.81000  ? 35  ARG A HH11   1 
ATOM   481  H HH12   . ARG A 1 35  ? 9.90200  -16.62200 1.64600   1.000 81.81000  ? 35  ARG A HH12   1 
ATOM   482  H HH21   . ARG A 1 35  ? 10.89300 -19.70400 1.03800   1.000 91.11000  ? 35  ARG A HH21   1 
ATOM   483  H HH22   . ARG A 1 35  ? 9.88700  -18.89900 1.78400   1.000 91.11000  ? 35  ARG A HH22   1 
ATOM   484  N N      . GLU A 1 36  ? 15.16800 -13.38100 0.69400   1.000 33.80000  ? 36  GLU A N      1 
ATOM   485  C CA     . GLU A 1 36  ? 14.67500 -12.06900 0.31700   1.000 40.63000  ? 36  GLU A CA     1 
ATOM   486  C C      . GLU A 1 36  ? 15.75300 -11.22000 -0.32900  1.000 35.17000  ? 36  GLU A C      1 
ATOM   487  O O      . GLU A 1 36  ? 15.47900 -10.46800 -1.28700  1.000 31.66000  ? 36  GLU A O      1 
ATOM   488  C CB     . GLU A 1 36  ? 14.12800 -11.37000 1.54100   1.000 37.33000  ? 36  GLU A CB     1 
ATOM   489  C CG     . GLU A 1 36  ? 13.02900 -12.17100 2.20200   1.000 60.75000  ? 36  GLU A CG     1 
ATOM   490  C CD     . GLU A 1 36  ? 11.88400 -12.48800 1.27100   1.000 57.87000  ? 36  GLU A CD     1 
ATOM   491  O OE1    . GLU A 1 36  ? 11.53800 -11.64300 0.40100   1.000 53.03000  ? 36  GLU A OE1    1 
ATOM   492  O OE2    . GLU A 1 36  ? 11.32000 -13.59700 1.41500   1.000 73.32000  ? 36  GLU A OE2    1 
ATOM   493  H H      . GLU A 1 36  ? 15.11500 -13.55900 1.53400   1.000 40.95000  ? 36  GLU A H      1 
ATOM   494  H HA     . GLU A 1 36  ? 13.96300 -12.18100 -0.33200  1.000 49.14000  ? 36  GLU A HA     1 
ATOM   495  H HB2    . GLU A 1 36  ? 14.84300 -11.24600 2.18400   1.000 45.18000  ? 36  GLU A HB2    1 
ATOM   496  H HB3    . GLU A 1 36  ? 13.76300 -10.51000 1.28100   1.000 45.18000  ? 36  GLU A HB3    1 
ATOM   497  H HG2    . GLU A 1 36  ? 13.39800 -13.01100 2.51800   1.000 73.29000  ? 36  GLU A HG2    1 
ATOM   498  H HG3    . GLU A 1 36  ? 12.67400 -11.66300 2.94800   1.000 73.29000  ? 36  GLU A HG3    1 
ATOM   499  N N      . LEU A 1 37  ? 16.98200 -11.28800 0.20500   1.000 37.05000  ? 37  LEU A N      1 
ATOM   500  C CA     . LEU A 1 37  ? 17.98000 -10.32600 -0.23300  1.000 34.28000  ? 37  LEU A CA     1 
ATOM   501  C C      . LEU A 1 37  ? 18.62400 -10.77700 -1.51900  1.000 30.94000  ? 37  LEU A C      1 
ATOM   502  O O      . LEU A 1 37  ? 18.96300 -9.93300  -2.36500  1.000 33.84000  ? 37  LEU A O      1 
ATOM   503  C CB     . LEU A 1 37  ? 19.01100 -10.12100 0.84100   1.000 31.82000  ? 37  LEU A CB     1 
ATOM   504  C CG     . LEU A 1 37  ? 18.43000 -9.54700  2.15400   1.000 40.67000  ? 37  LEU A CG     1 
ATOM   505  C CD1    . LEU A 1 37  ? 19.57000 -9.46500  3.17200   1.000 32.05000  ? 37  LEU A CD1    1 
ATOM   506  C CD2    . LEU A 1 37  ? 17.76200 -8.23100  1.93500   1.000 36.71000  ? 37  LEU A CD2    1 
ATOM   507  H H      . LEU A 1 37  ? 17.24200 -11.85800 0.79300   1.000 44.84000  ? 37  LEU A H      1 
ATOM   508  H HA     . LEU A 1 37  ? 17.56200 -9.46500  -0.38700  1.000 41.52000  ? 37  LEU A HA     1 
ATOM   509  H HB2    . LEU A 1 37  ? 19.42200 -10.97500 1.04700   1.000 38.56000  ? 37  LEU A HB2    1 
ATOM   510  H HB3    . LEU A 1 37  ? 19.68100 -9.50000  0.51600   1.000 38.56000  ? 37  LEU A HB3    1 
ATOM   511  H HG     . LEU A 1 37  ? 17.73300 -10.12400 2.50300   1.000 49.19000  ? 37  LEU A HG     1 
ATOM   512  H HD11   . LEU A 1 37  ? 19.22900 -9.08500  3.99700   1.000 38.84000  ? 37  LEU A HD11   1 
ATOM   513  H HD12   . LEU A 1 37  ? 19.91200 -10.35700 3.33500   1.000 38.84000  ? 37  LEU A HD12   1 
ATOM   514  H HD13   . LEU A 1 37  ? 20.27300 -8.90100  2.81400   1.000 38.84000  ? 37  LEU A HD13   1 
ATOM   515  H HD21   . LEU A 1 37  ? 17.45300 -7.88900  2.78800   1.000 44.44000  ? 37  LEU A HD21   1 
ATOM   516  H HD22   . LEU A 1 37  ? 18.39900 -7.61500  1.54200   1.000 44.44000  ? 37  LEU A HD22   1 
ATOM   517  H HD23   . LEU A 1 37  ? 17.00900 -8.35500  1.33600   1.000 44.44000  ? 37  LEU A HD23   1 
ATOM   518  N N      . ILE A 1 38  ? 18.80000 -12.09100 -1.67000  1.000 31.44000  ? 38  ILE A N      1 
ATOM   519  C CA     . ILE A 1 38  ? 19.18000 -12.66700 -2.94700  1.000 30.70000  ? 38  ILE A CA     1 
ATOM   520  C C      . ILE A 1 38  ? 18.11100 -12.40800 -3.95800  1.000 36.55000  ? 38  ILE A C      1 
ATOM   521  O O      . ILE A 1 38  ? 18.40500 -12.30100 -5.13200  1.000 27.79000  ? 38  ILE A O      1 
ATOM   522  C CB     . ILE A 1 38  ? 19.42700 -14.17000 -2.75200  1.000 30.80000  ? 38  ILE A CB     1 
ATOM   523  C CG1    . ILE A 1 38  ? 20.65300 -14.38900 -1.84200  1.000 32.27000  ? 38  ILE A CG1    1 
ATOM   524  C CG2    . ILE A 1 38  ? 19.62800 -14.86000 -4.08500  1.000 30.96000  ? 38  ILE A CG2    1 
ATOM   525  C CD1    . ILE A 1 38  ? 20.90400 -15.88000 -1.47800  1.000 35.85000  ? 38  ILE A CD1    1 
ATOM   526  H H      . ILE A 1 38  ? 18.70400 -12.67100 -1.04200  1.000 38.12000  ? 38  ILE A H      1 
ATOM   527  H HA     . ILE A 1 38  ? 19.99800 -12.25600 -3.27000  1.000 37.23000  ? 38  ILE A HA     1 
ATOM   528  H HB     . ILE A 1 38  ? 18.64400 -14.55500 -2.32700  1.000 37.34000  ? 38  ILE A HB     1 
ATOM   529  H HG12   . ILE A 1 38  ? 21.44300 -14.05900 -2.29800  1.000 39.11000  ? 38  ILE A HG12   1 
ATOM   530  H HG13   . ILE A 1 38  ? 20.51800 -13.90100 -1.01500  1.000 39.11000  ? 38  ILE A HG13   1 
ATOM   531  H HG21   . ILE A 1 38  ? 19.80700 -15.80100 -3.92900  1.000 37.53000  ? 38  ILE A HG21   1 
ATOM   532  H HG22   . ILE A 1 38  ? 18.82200 -14.76100 -4.61600  1.000 37.53000  ? 38  ILE A HG22   1 
ATOM   533  H HG23   . ILE A 1 38  ? 20.37900 -14.45100 -4.54200  1.000 37.53000  ? 38  ILE A HG23   1 
ATOM   534  H HD11   . ILE A 1 38  ? 21.55100 -15.92500 -0.75700  1.000 43.40000  ? 38  ILE A HD11   1 
ATOM   535  H HD12   . ILE A 1 38  ? 20.06700 -16.28200 -1.19700  1.000 43.40000  ? 38  ILE A HD12   1 
ATOM   536  H HD13   . ILE A 1 38  ? 21.24700 -16.34300 -2.25900  1.000 43.40000  ? 38  ILE A HD13   1 
ATOM   537  N N      . SER A 1 39  ? 16.85400 -12.33600 -3.54400  1.000 46.82000  ? 39  SER A N      1 
ATOM   538  C CA     . SER A 1 39  ? 15.81500 -12.09700 -4.53100  1.000 36.52000  ? 39  SER A CA     1 
ATOM   539  C C      . SER A 1 39  ? 15.88600 -10.66700 -5.04200  1.000 41.13000  ? 39  SER A C      1 
ATOM   540  O O      . SER A 1 39  ? 15.76300 -10.44500 -6.25600  1.000 27.97000  ? 39  SER A O      1 
ATOM   541  C CB     . SER A 1 39  ? 14.44200 -12.39800 -3.95000  1.000 40.90000  ? 39  SER A CB     1 
ATOM   542  O OG     . SER A 1 39  ? 13.47300 -11.69600 -4.70300  1.000 68.37000  ? 39  SER A OG     1 
ATOM   543  H H      . SER A 1 39  ? 16.58700 -12.41900 -2.73100  1.000 56.56000  ? 39  SER A H      1 
ATOM   544  H HA     . SER A 1 39  ? 15.94600 -12.70000 -5.28000  1.000 44.20000  ? 39  SER A HA     1 
ATOM   545  H HB2    . SER A 1 39  ? 14.26800 -13.35100 -4.00500  1.000 49.47000  ? 39  SER A HB2    1 
ATOM   546  H HB3    . SER A 1 39  ? 14.40900 -12.10700 -3.02600  1.000 49.47000  ? 39  SER A HB3    1 
ATOM   547  H HG     . SER A 1 39  ? 12.72000 -12.05400 -4.60600  1.000 82.42000  ? 39  SER A HG     1 
ATOM   548  N N      . ASN A 1 40  ? 16.09800 -9.69200  -4.13400  1.000 28.92000  ? 40  ASN A N      1 
ATOM   549  C CA     . ASN A 1 40  ? 16.39700 -8.32900  -4.55900  1.000 31.08000  ? 40  ASN A CA     1 
ATOM   550  C C      . ASN A 1 40  ? 17.57900 -8.31400  -5.48400  1.000 41.79000  ? 40  ASN A C      1 
ATOM   551  O O      . ASN A 1 40  ? 17.56000 -7.65700  -6.51300  1.000 41.00000  ? 40  ASN A O      1 
ATOM   552  C CB     . ASN A 1 40  ? 16.71700 -7.45900  -3.34300  1.000 43.96000  ? 40  ASN A CB     1 
ATOM   553  C CG     . ASN A 1 40  ? 15.50700 -7.16000  -2.51500  1.000 37.65000  ? 40  ASN A CG     1 
ATOM   554  O OD1    . ASN A 1 40  ? 14.42400 -7.62700  -2.82000  1.000 43.03000  ? 40  ASN A OD1    1 
ATOM   555  N ND2    . ASN A 1 40  ? 15.69000 -6.40900  -1.43100  1.000 52.12000  ? 40  ASN A ND2    1 
ATOM   556  H H      . ASN A 1 40  ? 16.07300 -9.80200  -3.28200  1.000 35.09000  ? 40  ASN A H      1 
ATOM   557  H HA     . ASN A 1 40  ? 15.61900 -7.96600  -5.01200  1.000 37.67000  ? 40  ASN A HA     1 
ATOM   558  H HB2    . ASN A 1 40  ? 17.35800 -7.92300  -2.78200  1.000 53.13000  ? 40  ASN A HB2    1 
ATOM   559  H HB3    . ASN A 1 40  ? 17.09000 -6.61700  -3.64600  1.000 53.13000  ? 40  ASN A HB3    1 
ATOM   560  H HD21   . ASN A 1 40  ? 16.47600 -6.12000  -1.23500  1.000 62.93000  ? 40  ASN A HD21   1 
ATOM   561  H HD22   . ASN A 1 40  ? 15.02200 -6.21200  -0.92600  1.000 62.93000  ? 40  ASN A HD22   1 
ATOM   562  N N      . ALA A 1 41  ? 18.64300 -9.02500  -5.12500  1.000 36.10000  ? 41  ALA A N      1 
ATOM   563  C CA     . ALA A 1 41  ? 19.85200 -8.89300  -5.91700  1.000 34.66000  ? 41  ALA A CA     1 
ATOM   564  C C      . ALA A 1 41  ? 19.58900 -9.40700  -7.32000  1.000 35.77000  ? 41  ALA A C      1 
ATOM   565  O O      . ALA A 1 41  ? 20.00700 -8.79300  -8.31700  1.000 34.86000  ? 41  ALA A O      1 
ATOM   566  C CB     . ALA A 1 41  ? 20.99200 -9.61200  -5.24200  1.000 29.82000  ? 41  ALA A CB     1 
ATOM   567  H H      . ALA A 1 41  ? 18.68700 -9.56500  -4.45700  1.000 43.70000  ? 41  ALA A H      1 
ATOM   568  H HA     . ALA A 1 41  ? 20.12300 -7.96400  -5.98300  1.000 41.97000  ? 41  ALA A HA     1 
ATOM   569  H HB1    . ALA A 1 41  ? 21.74700 -9.64800  -5.85000  1.000 36.16000  ? 41  ALA A HB1    1 
ATOM   570  H HB2    . ALA A 1 41  ? 21.23800 -9.12900  -4.43800  1.000 36.16000  ? 41  ALA A HB2    1 
ATOM   571  H HB3    . ALA A 1 41  ? 20.70800 -10.51100 -5.01400  1.000 36.16000  ? 41  ALA A HB3    1 
ATOM   572  N N      . SER A 1 42  ? 18.86300 -10.52200 -7.40100  1.000 34.50000  ? 42  SER A N      1 
ATOM   573  C CA     . SER A 1 42  ? 18.47000 -11.07700 -8.68600  1.000 33.22000  ? 42  SER A CA     1 
ATOM   574  C C      . SER A 1 42  ? 17.62300 -10.08500 -9.46200  1.000 37.59000  ? 42  SER A C      1 
ATOM   575  O O      . SER A 1 42  ? 17.79300 -9.91900  -10.67300 1.000 40.50000  ? 42  SER A O      1 
ATOM   576  C CB     . SER A 1 42  ? 17.69300 -12.38100 -8.51500  1.000 37.56000  ? 42  SER A CB     1 
ATOM   577  O OG     . SER A 1 42  ? 17.35100 -12.92100 -9.79200  1.000 36.18000  ? 42  SER A OG     1 
ATOM   578  H H      . SER A 1 42  ? 18.58600 -10.97500 -6.72400  1.000 41.78000  ? 42  SER A H      1 
ATOM   579  H HA     . SER A 1 42  ? 19.27800 -11.27600 -9.18400  1.000 40.24000  ? 42  SER A HA     1 
ATOM   580  H HB2    . SER A 1 42  ? 18.24500 -13.02000 -8.03700  1.000 45.46000  ? 42  SER A HB2    1 
ATOM   581  H HB3    . SER A 1 42  ? 16.88100 -12.20500 -8.01600  1.000 45.46000  ? 42  SER A HB3    1 
ATOM   582  H HG     . SER A 1 42  ? 16.76500 -12.44300 -10.15800 1.000 43.80000  ? 42  SER A HG     1 
ATOM   583  N N      . ASP A 1 43  ? 16.73200 -9.38000  -8.78400  1.000 29.25000  ? 43  ASP A N      1 
ATOM   584  C CA     . ASP A 1 43  ? 15.95500 -8.39300  -9.51200  1.000 38.49000  ? 43  ASP A CA     1 
ATOM   585  C C      . ASP A 1 43  ? 16.83100 -7.28600  -10.02400 1.000 41.07000  ? 43  ASP A C      1 
ATOM   586  O O      . ASP A 1 43  ? 16.62200 -6.81800  -11.14400 1.000 43.78000  ? 43  ASP A O      1 
ATOM   587  C CB     . ASP A 1 43  ? 14.84200 -7.83000  -8.67800  1.000 37.50000  ? 43  ASP A CB     1 
ATOM   588  C CG     . ASP A 1 43  ? 13.75900 -8.87900  -8.41000  1.000 44.34000  ? 43  ASP A CG     1 
ATOM   589  O OD1    . ASP A 1 43  ? 13.72100 -9.91300  -9.16000  1.000 44.30000  ? 43  ASP A OD1    1 
ATOM   590  O OD2    . ASP A 1 43  ? 12.99000 -8.66700  -7.43300  1.000 46.67000  ? 43  ASP A OD2    1 
ATOM   591  H H      . ASP A 1 43  ? 16.56600 -9.45000  -7.94300  1.000 35.48000  ? 43  ASP A H      1 
ATOM   592  H HA     . ASP A 1 43  ? 15.54200 -8.84400  -10.26500 1.000 46.57000  ? 43  ASP A HA     1 
ATOM   593  H HB2    . ASP A 1 43  ? 15.19800 -7.53300  -7.82500  1.000 45.38000  ? 43  ASP A HB2    1 
ATOM   594  H HB3    . ASP A 1 43  ? 14.43600 -7.08400  -9.14500  1.000 45.38000  ? 43  ASP A HB3    1 
ATOM   595  N N      . ALA A 1 44  ? 17.82600 -6.87300  -9.24800  1.000 27.07000  ? 44  ALA A N      1 
ATOM   596  C CA     . ALA A 1 44  ? 18.63100 -5.72500  -9.67900  1.000 42.70000  ? 44  ALA A CA     1 
ATOM   597  C C      . ALA A 1 44  ? 19.49500 -6.13600  -10.85300 1.000 36.58000  ? 44  ALA A C      1 
ATOM   598  O O      . ALA A 1 44  ? 19.77000 -5.34700  -11.75600 1.000 39.34000  ? 44  ALA A O      1 
ATOM   599  C CB     . ALA A 1 44  ? 19.51300 -5.19400  -8.54000  1.000 31.73000  ? 44  ALA A CB     1 
ATOM   600  H H      . ALA A 1 44  ? 18.05200 -7.22200  -8.49500  1.000 32.87000  ? 44  ALA A H      1 
ATOM   601  H HA     . ALA A 1 44  ? 18.04100 -4.99700  -9.93000  1.000 51.62000  ? 44  ALA A HA     1 
ATOM   602  H HB1    . ALA A 1 44  ? 20.00200 -4.41800  -8.85500  1.000 38.46000  ? 44  ALA A HB1    1 
ATOM   603  H HB2    . ALA A 1 44  ? 18.94800 -4.94800  -7.79100  1.000 38.46000  ? 44  ALA A HB2    1 
ATOM   604  H HB3    . ALA A 1 44  ? 20.13400 -5.89000  -8.27100  1.000 38.46000  ? 44  ALA A HB3    1 
ATOM   605  N N      . LEU A 1 45  ? 19.91600 -7.39100  -10.86500 1.000 34.89000  ? 45  LEU A N      1 
ATOM   606  C CA     . LEU A 1 45  ? 20.61000 -7.92700  -12.01900 1.000 38.49000  ? 45  LEU A CA     1 
ATOM   607  C C      . LEU A 1 45  ? 19.70300 -7.99900  -13.23900 1.000 50.14000  ? 45  LEU A C      1 
ATOM   608  O O      . LEU A 1 45  ? 20.16200 -7.72200  -14.36800 1.000 30.52000  ? 45  LEU A O      1 
ATOM   609  C CB     . LEU A 1 45  ? 21.17200 -9.29100  -11.65300 1.000 26.53000  ? 45  LEU A CB     1 
ATOM   610  C CG     . LEU A 1 45  ? 22.34600 -9.16500  -10.64700 1.000 29.06000  ? 45  LEU A CG     1 
ATOM   611  C CD1    . LEU A 1 45  ? 22.53700 -10.40800 -9.82500  1.000 33.28000  ? 45  LEU A CD1    1 
ATOM   612  C CD2    . LEU A 1 45  ? 23.59400 -8.93900  -11.42400 1.000 41.35000  ? 45  LEU A CD2    1 
ATOM   613  H H      . LEU A 1 45  ? 19.81200 -7.95100  -10.22000 1.000 42.25000  ? 45  LEU A H      1 
ATOM   614  H HA     . LEU A 1 45  ? 21.34800 -7.34600  -12.26200 1.000 46.57000  ? 45  LEU A HA     1 
ATOM   615  H HB2    . LEU A 1 45  ? 20.47400 -9.82600  -11.24500 1.000 32.22000  ? 45  LEU A HB2    1 
ATOM   616  H HB3    . LEU A 1 45  ? 21.50000 -9.72800  -12.45500 1.000 32.22000  ? 45  LEU A HB3    1 
ATOM   617  H HG     . LEU A 1 45  ? 22.15200 -8.43400  -10.03900 1.000 35.25000  ? 45  LEU A HG     1 
ATOM   618  H HD11   . LEU A 1 45  ? 23.27300 -10.27000 -9.21000  1.000 40.32000  ? 45  LEU A HD11   1 
ATOM   619  H HD12   . LEU A 1 45  ? 21.72200 -10.58800 -9.33100  1.000 40.32000  ? 45  LEU A HD12   1 
ATOM   620  H HD13   . LEU A 1 45  ? 22.73500 -11.15000 -10.41700 1.000 40.32000  ? 45  LEU A HD13   1 
ATOM   621  H HD21   . LEU A 1 45  ? 24.29900 -8.66600  -10.81600 1.000 50.00000  ? 45  LEU A HD21   1 
ATOM   622  H HD22   . LEU A 1 45  ? 23.84200 -9.76400  -11.86900 1.000 50.00000  ? 45  LEU A HD22   1 
ATOM   623  H HD23   . LEU A 1 45  ? 23.43600 -8.24300  -12.08000 1.000 50.00000  ? 45  LEU A HD23   1 
ATOM   624  N N      . ASP A 1 46  ? 18.43200 -8.40600  -13.04600 1.000 38.33000  ? 46  ASP A N      1 
ATOM   625  C CA     . ASP A 1 46  ? 17.49900 -8.46500  -14.17400 1.000 39.42000  ? 46  ASP A CA     1 
ATOM   626  C C      . ASP A 1 46  ? 17.47200 -7.10900  -14.88000 1.000 33.20000  ? 46  ASP A C      1 
ATOM   627  O O      . ASP A 1 46  ? 17.51600 -7.01700  -16.11600 1.000 37.66000  ? 46  ASP A O      1 
ATOM   628  C CB     . ASP A 1 46  ? 16.08700 -8.83900  -13.68600 1.000 39.93000  ? 46  ASP A CB     1 
ATOM   629  C CG     . ASP A 1 46  ? 15.90200 -10.32700 -13.50100 1.000 38.32000  ? 46  ASP A CG     1 
ATOM   630  O OD1    . ASP A 1 46  ? 16.72200 -11.12400 -14.02700 1.000 34.78000  ? 46  ASP A OD1    1 
ATOM   631  O OD2    . ASP A 1 46  ? 14.99500 -10.72200 -12.74300 1.000 41.62000  ? 46  ASP A OD2    1 
ATOM   632  H H      . ASP A 1 46  ? 18.10000 -8.64600  -12.28900 1.000 46.38000  ? 46  ASP A H      1 
ATOM   633  H HA     . ASP A 1 46  ? 17.78200 -9.15300  -14.79700 1.000 47.69000  ? 46  ASP A HA     1 
ATOM   634  H HB2    . ASP A 1 46  ? 15.92400 -8.40900  -12.83200 1.000 48.29000  ? 46  ASP A HB2    1 
ATOM   635  H HB3    . ASP A 1 46  ? 15.43800 -8.53600  -14.34000 1.000 48.29000  ? 46  ASP A HB3    1 
ATOM   636  N N      . LYS A 1 47  ? 17.51300 -6.03800  -14.09400 1.000 34.86000  ? 47  LYS A N      1 
ATOM   637  C CA     . LYS A 1 47  ? 17.31000 -4.70400  -14.62700 1.000 37.78000  ? 47  LYS A CA     1 
ATOM   638  C C      . LYS A 1 47  ? 18.51100 -4.21800  -15.41200 1.000 43.62000  ? 47  LYS A C      1 
ATOM   639  O O      . LYS A 1 47  ? 18.36000 -3.57400  -16.45900 1.000 42.50000  ? 47  LYS A O      1 
ATOM   640  C CB     . LYS A 1 47  ? 16.98600 -3.78900  -13.46900 1.000 27.92000  ? 47  LYS A CB     1 
ATOM   641  C CG     . LYS A 1 47  ? 15.79000 -4.24200  -12.70400 1.000 37.62000  ? 47  LYS A CG     1 
ATOM   642  C CD     . LYS A 1 47  ? 15.00900 -3.11100  -11.93800 1.000 44.05000  ? 47  LYS A CD     1 
ATOM   643  C CE     . LYS A 1 47  ? 13.83200 -3.74500  -11.12700 1.000 46.49000  ? 47  LYS A CE     1 
ATOM   644  N NZ     . LYS A 1 47  ? 13.70300 -3.19300  -9.75100  1.000 81.70000  ? 47  LYS A NZ     1 
ATOM   645  H H      . LYS A 1 47  ? 17.65900 -6.06000  -13.24700 1.000 42.22000  ? 47  LYS A H      1 
ATOM   646  H HA     . LYS A 1 47  ? 16.56600 -4.70100  -15.25000 1.000 45.72000  ? 47  LYS A HA     1 
ATOM   647  H HB2    . LYS A 1 47  ? 17.74200 -3.76700  -12.86200 1.000 33.89000  ? 47  LYS A HB2    1 
ATOM   648  H HB3    . LYS A 1 47  ? 16.80700 -2.89800  -13.80900 1.000 33.89000  ? 47  LYS A HB3    1 
ATOM   649  H HG2    . LYS A 1 47  ? 15.16700 -4.65300  -13.32400 1.000 45.52000  ? 47  LYS A HG2    1 
ATOM   650  H HG3    . LYS A 1 47  ? 16.07700 -4.89100  -12.04300 1.000 45.52000  ? 47  LYS A HG3    1 
ATOM   651  H HD2    . LYS A 1 47  ? 15.60600 -2.65900  -11.32200 1.000 53.24000  ? 47  LYS A HD2    1 
ATOM   652  H HD3    . LYS A 1 47  ? 14.64400 -2.47600  -12.57400 1.000 53.24000  ? 47  LYS A HD3    1 
ATOM   653  H HE2    . LYS A 1 47  ? 13.00000 -3.57400  -11.59500 1.000 56.17000  ? 47  LYS A HE2    1 
ATOM   654  H HE3    . LYS A 1 47  ? 13.98100 -4.70000  -11.05200 1.000 56.17000  ? 47  LYS A HE3    1 
ATOM   655  H HZ1    . LYS A 1 47  ? 12.99100 -3.54400  -9.34800  1.000 98.42000  ? 47  LYS A HZ1    1 
ATOM   656  H HZ2    . LYS A 1 47  ? 14.43000 -3.38800  -9.27600  1.000 98.42000  ? 47  LYS A HZ2    1 
ATOM   657  H HZ3    . LYS A 1 47  ? 13.60900 -2.30900  -9.78500  1.000 98.42000  ? 47  LYS A HZ3    1 
ATOM   658  N N      . ILE A 1 48  ? 19.71400 -4.51300  -14.94400 1.000 38.47000  ? 48  ILE A N      1 
ATOM   659  C CA     . ILE A 1 48  ? 20.87200 -4.20100  -15.78000 1.000 31.66000  ? 48  ILE A CA     1 
ATOM   660  C C      . ILE A 1 48  ? 20.88800 -5.12500  -16.99500 1.000 41.12000  ? 48  ILE A C      1 
ATOM   661  O O      . ILE A 1 48  ? 21.26500 -4.72900  -18.09200 1.000 39.00000  ? 48  ILE A O      1 
ATOM   662  C CB     . ILE A 1 48  ? 22.17200 -4.28900  -14.95500 1.000 38.32000  ? 48  ILE A CB     1 
ATOM   663  C CG1    . ILE A 1 48  ? 23.36100 -3.77700  -15.78200 1.000 42.45000  ? 48  ILE A CG1    1 
ATOM   664  C CG2    . ILE A 1 48  ? 22.46700 -5.68100  -14.48100 1.000 36.26000  ? 48  ILE A CG2    1 
ATOM   665  C CD1    . ILE A 1 48  ? 23.26700 -2.29100  -16.02500 1.000 45.21000  ? 48  ILE A CD1    1 
ATOM   666  H H      . ILE A 1 48  ? 19.88400 -4.87700  -14.18400 1.000 46.54000  ? 48  ILE A H      1 
ATOM   667  H HA     . ILE A 1 48  ? 20.80200 -3.28700  -16.09800 1.000 38.37000  ? 48  ILE A HA     1 
ATOM   668  H HB     . ILE A 1 48  ? 22.03700 -3.73200  -14.17300 1.000 46.36000  ? 48  ILE A HB     1 
ATOM   669  H HG12   . ILE A 1 48  ? 24.18500 -3.95700  -15.30400 1.000 51.32000  ? 48  ILE A HG12   1 
ATOM   670  H HG13   . ILE A 1 48  ? 23.37100 -4.22700  -16.64200 1.000 51.32000  ? 48  ILE A HG13   1 
ATOM   671  H HG21   . ILE A 1 48  ? 23.31000 -5.67900  -14.00300 1.000 43.89000  ? 48  ILE A HG21   1 
ATOM   672  H HG22   . ILE A 1 48  ? 21.75300 -5.97200  -13.89300 1.000 43.89000  ? 48  ILE A HG22   1 
ATOM   673  H HG23   . ILE A 1 48  ? 22.52300 -6.27100  -15.25000 1.000 43.89000  ? 48  ILE A HG23   1 
ATOM   674  H HD11   . ILE A 1 48  ? 23.98100 -2.02300  -16.62400 1.000 54.63000  ? 48  ILE A HD11   1 
ATOM   675  H HD12   . ILE A 1 48  ? 22.40600 -2.09000  -16.42500 1.000 54.63000  ? 48  ILE A HD12   1 
ATOM   676  H HD13   . ILE A 1 48  ? 23.35400 -1.82600  -15.17700 1.000 54.63000  ? 48  ILE A HD13   1 
ATOM   677  N N      . ARG A 1 49  ? 20.47400 -6.37600  -16.83000 1.000 42.23000  ? 49  ARG A N      1 
ATOM   678  C CA     . ARG A 1 49  ? 20.37600 -7.27200  -17.98700 1.000 38.52000  ? 49  ARG A CA     1 
ATOM   679  C C      . ARG A 1 49  ? 19.47100 -6.67800  -19.07100 1.000 45.94000  ? 49  ARG A C      1 
ATOM   680  O O      . ARG A 1 49  ? 19.79800 -6.71800  -20.25800 1.000 44.86000  ? 49  ARG A O      1 
ATOM   681  C CB     . ARG A 1 49  ? 19.83600 -8.63300  -17.56500 1.000 48.92000  ? 49  ARG A CB     1 
ATOM   682  C CG     . ARG A 1 49  ? 20.49700 -9.78900  -18.24000 1.000 53.36000  ? 49  ARG A CG     1 
ATOM   683  C CD     . ARG A 1 49  ? 19.61800 -11.05300 -18.28500 1.000 75.22000  ? 49  ARG A CD     1 
ATOM   684  N NE     . ARG A 1 49  ? 20.30200 -12.06300 -19.08900 1.000 102.44000 ? 49  ARG A NE     1 
ATOM   685  C CZ     . ARG A 1 49  ? 20.47200 -11.99900 -20.40800 1.000 101.70000 ? 49  ARG A CZ     1 
ATOM   686  N NH1    . ARG A 1 49  ? 19.91600 -11.04100 -21.12800 1.000 78.28000  ? 49  ARG A NH1    1 
ATOM   687  N NH2    . ARG A 1 49  ? 21.21000 -12.92900 -21.02300 1.000 73.55000  ? 49  ARG A NH2    1 
ATOM   688  H H      . ARG A 1 49  ? 20.24700 -6.72800  -16.07900 1.000 51.05000  ? 49  ARG A H      1 
ATOM   689  H HA     . ARG A 1 49  ? 21.26700 -7.39300  -18.35100 1.000 46.61000  ? 49  ARG A HA     1 
ATOM   690  H HB2    . ARG A 1 49  ? 19.96600 -8.73600  -16.60900 1.000 59.09000  ? 49  ARG A HB2    1 
ATOM   691  H HB3    . ARG A 1 49  ? 18.89000 -8.67000  -17.77600 1.000 59.09000  ? 49  ARG A HB3    1 
ATOM   692  H HG2    . ARG A 1 49  ? 20.70700 -9.54100  -19.15400 1.000 64.41000  ? 49  ARG A HG2    1 
ATOM   693  H HG3    . ARG A 1 49  ? 21.31100 -10.00900 -17.76000 1.000 64.41000  ? 49  ARG A HG3    1 
ATOM   694  H HD2    . ARG A 1 49  ? 19.48400 -11.39800 -17.38800 1.000 90.65000  ? 49  ARG A HD2    1 
ATOM   695  H HD3    . ARG A 1 49  ? 18.76200 -10.84900 -18.69300 1.000 90.65000  ? 49  ARG A HD3    1 
ATOM   696  H HE     . ARG A 1 49  ? 20.61800 -12.75100 -18.68000 1.000 123.31000 ? 49  ARG A HE     1 
ATOM   697  H HH11   . ARG A 1 49  ? 19.43200 -10.44100 -20.74600 1.000 94.31000  ? 49  ARG A HH11   1 
ATOM   698  H HH12   . ARG A 1 49  ? 20.03900 -11.01600 -21.97900 1.000 94.31000  ? 49  ARG A HH12   1 
ATOM   699  H HH21   . ARG A 1 49  ? 21.57100 -13.56300 -20.56800 1.000 88.64000  ? 49  ARG A HH21   1 
ATOM   700  H HH22   . ARG A 1 49  ? 21.32500 -12.89300 -21.87500 1.000 88.64000  ? 49  ARG A HH22   1 
ATOM   701  N N      . TYR A 1 50  ? 18.33700 -6.10800  -18.67400 1.000 39.18000  ? 50  TYR A N      1 
ATOM   702  C CA     . TYR A 1 50  ? 17.43100 -5.50600  -19.64000 1.000 49.65000  ? 50  TYR A CA     1 
ATOM   703  C C      . TYR A 1 50  ? 18.10100 -4.35100  -20.37800 1.000 54.56000  ? 50  TYR A C      1 
ATOM   704  O O      . TYR A 1 50  ? 18.13300 -4.33200  -21.61700 1.000 50.72000  ? 50  TYR A O      1 
ATOM   705  C CB     . TYR A 1 50  ? 16.16100 -5.06100  -18.89900 1.000 57.05000  ? 50  TYR A CB     1 
ATOM   706  C CG     . TYR A 1 50  ? 15.12600 -4.47500  -19.79700 1.000 50.47000  ? 50  TYR A CG     1 
ATOM   707  C CD1    . TYR A 1 50  ? 15.21800 -3.15700  -20.18600 1.000 55.67000  ? 50  TYR A CD1    1 
ATOM   708  C CD2    . TYR A 1 50  ? 14.07600 -5.24600  -20.29800 1.000 53.27000  ? 50  TYR A CD2    1 
ATOM   709  C CE1    . TYR A 1 50  ? 14.29800 -2.60100  -21.05000 1.000 62.03000  ? 50  TYR A CE1    1 
ATOM   710  C CE2    . TYR A 1 50  ? 13.14500 -4.68900  -21.16400 1.000 49.58000  ? 50  TYR A CE2    1 
ATOM   711  C CZ     . TYR A 1 50  ? 13.26400 -3.35300  -21.51900 1.000 52.49000  ? 50  TYR A CZ     1 
ATOM   712  O OH     . TYR A 1 50  ? 12.37600 -2.74400  -22.35800 1.000 71.37000  ? 50  TYR A OH     1 
ATOM   713  H H      . TYR A 1 50  ? 18.07200 -6.05800  -17.85800 1.000 47.40000  ? 50  TYR A H      1 
ATOM   714  H HA     . TYR A 1 50  ? 17.17800 -6.15400  -20.31500 1.000 59.96000  ? 50  TYR A HA     1 
ATOM   715  H HB2    . TYR A 1 50  ? 15.77000 -5.83100  -18.45700 1.000 68.84000  ? 50  TYR A HB2    1 
ATOM   716  H HB3    . TYR A 1 50  ? 16.40000 -4.38800  -18.24300 1.000 68.84000  ? 50  TYR A HB3    1 
ATOM   717  H HD1    . TYR A 1 50  ? 15.91400 -2.63300  -19.86100 1.000 67.19000  ? 50  TYR A HD1    1 
ATOM   718  H HD2    . TYR A 1 50  ? 13.99900 -6.13900  -20.04900 1.000 64.31000  ? 50  TYR A HD2    1 
ATOM   719  H HE1    . TYR A 1 50  ? 14.38300 -1.71200  -21.31200 1.000 74.81000  ? 50  TYR A HE1    1 
ATOM   720  H HE2    . TYR A 1 50  ? 12.45000 -5.20500  -21.50300 1.000 59.88000  ? 50  TYR A HE2    1 
ATOM   721  H HH     . TYR A 1 50  ? 12.65500 -1.97900  -22.56500 1.000 86.03000  ? 50  TYR A HH     1 
ATOM   722  N N      . GLN A 1 51  ? 18.65400 -3.38200  -19.63100 1.000 38.95000  ? 51  GLN A N      1 
ATOM   723  C CA     . GLN A 1 51  ? 19.31400 -2.23500  -20.25700 1.000 35.82000  ? 51  GLN A CA     1 
ATOM   724  C C      . GLN A 1 51  ? 20.44200 -2.67300  -21.18200 1.000 42.19000  ? 51  GLN A C      1 
ATOM   725  O O      . GLN A 1 51  ? 20.67000 -2.05100  -22.21300 1.000 56.20000  ? 51  GLN A O      1 
ATOM   726  C CB     . GLN A 1 51  ? 19.82700 -1.24900  -19.18000 1.000 43.70000  ? 51  GLN A CB     1 
ATOM   727  C CG     . GLN A 1 51  ? 18.70300 -0.58000  -18.36500 1.000 46.45000  ? 51  GLN A CG     1 
ATOM   728  C CD     . GLN A 1 51  ? 19.15400 0.66600   -17.56700 1.000 56.54000  ? 51  GLN A CD     1 
ATOM   729  O OE1    . GLN A 1 51  ? 20.26700 1.15600   -17.70200 1.000 56.79000  ? 51  GLN A OE1    1 
ATOM   730  N NE2    . GLN A 1 51  ? 18.26500 1.16800   -16.73400 1.000 54.37000  ? 51  GLN A NE2    1 
ATOM   731  H H      . GLN A 1 51  ? 18.65800 -3.36700  -18.77200 1.000 47.12000  ? 51  GLN A H      1 
ATOM   732  H HA     . GLN A 1 51  ? 18.66400 -1.75700  -20.79500 1.000 43.37000  ? 51  GLN A HA     1 
ATOM   733  H HB2    . GLN A 1 51  ? 20.39500 -1.73300  -18.55900 1.000 52.83000  ? 51  GLN A HB2    1 
ATOM   734  H HB3    . GLN A 1 51  ? 20.33500 -0.54700  -19.61600 1.000 52.83000  ? 51  GLN A HB3    1 
ATOM   735  H HG2    . GLN A 1 51  ? 18.00200 -0.30000  -18.97400 1.000 56.12000  ? 51  GLN A HG2    1 
ATOM   736  H HG3    . GLN A 1 51  ? 18.35300 -1.22400  -17.73000 1.000 56.12000  ? 51  GLN A HG3    1 
ATOM   737  H HE21   . GLN A 1 51  ? 17.49000 0.80300   -16.66100 1.000 65.63000  ? 51  GLN A HE21   1 
ATOM   738  H HE22   . GLN A 1 51  ? 18.46000 1.86100   -16.26300 1.000 65.63000  ? 51  GLN A HE22   1 
ATOM   739  N N      . ALA A 1 52  ? 21.11900 -3.75500  -20.86900 1.000 38.20000  ? 52  ALA A N      1 
ATOM   740  C CA     . ALA A 1 52  ? 22.22900 -4.21400  -21.69600 1.000 51.51000  ? 52  ALA A CA     1 
ATOM   741  C C      . ALA A 1 52  ? 21.78900 -4.91500  -22.97600 1.000 51.90000  ? 52  ALA A C      1 
ATOM   742  O O      . ALA A 1 52  ? 22.59800 -5.05900  -23.88300 1.000 46.63000  ? 52  ALA A O      1 
ATOM   743  C CB     . ALA A 1 52  ? 23.13200 -5.17400  -20.91000 1.000 34.33000  ? 52  ALA A CB     1 
ATOM   744  H H      . ALA A 1 52  ? 20.96100 -4.24800  -20.18200 1.000 46.22000  ? 52  ALA A H      1 
ATOM   745  H HA     . ALA A 1 52  ? 22.74500 -3.43000  -21.93900 1.000 62.20000  ? 52  ALA A HA     1 
ATOM   746  H HB1    . ALA A 1 52  ? 23.82700 -5.50800  -21.49900 1.000 41.58000  ? 52  ALA A HB1    1 
ATOM   747  H HB2    . ALA A 1 52  ? 23.53100 -4.69500  -20.16700 1.000 41.58000  ? 52  ALA A HB2    1 
ATOM   748  H HB3    . ALA A 1 52  ? 22.59700 -5.91100  -20.57800 1.000 41.58000  ? 52  ALA A HB3    1 
ATOM   749  N N      . LEU A 1 53  ? 20.56400 -5.42000  -23.04700 1.000 52.30000  ? 53  LEU A N      1 
ATOM   750  C CA     . LEU A 1 53  ? 20.01400 -5.82700  -24.34100 1.000 57.50000  ? 53  LEU A CA     1 
ATOM   751  C C      . LEU A 1 53  ? 19.94700 -4.64000  -25.32000 1.000 66.01000  ? 53  LEU A C      1 
ATOM   752  O O      . LEU A 1 53  ? 20.38500 -4.73400  -26.46800 1.000 61.30000  ? 53  LEU A O      1 
ATOM   753  C CB     . LEU A 1 53  ? 18.61900 -6.43300  -24.15400 1.000 68.10000  ? 53  LEU A CB     1 
ATOM   754  C CG     . LEU A 1 53  ? 18.52400 -7.93400  -23.92000 1.000 78.97000  ? 53  LEU A CG     1 
ATOM   755  C CD1    . LEU A 1 53  ? 17.18500 -8.32200  -23.30500 1.000 77.35000  ? 53  LEU A CD1    1 
ATOM   756  C CD2    . LEU A 1 53  ? 18.73400 -8.65800  -25.25600 1.000 89.60000  ? 53  LEU A CD2    1 
ATOM   757  H H      . LEU A 1 53  ? 20.03800 -5.53600  -22.37700 1.000 63.14000  ? 53  LEU A H      1 
ATOM   758  H HA     . LEU A 1 53  ? 20.59600 -6.50400  -24.72000 1.000 69.38000  ? 53  LEU A HA     1 
ATOM   759  H HB2    . LEU A 1 53  ? 18.21100 -6.00300  -23.38600 1.000 82.10000  ? 53  LEU A HB2    1 
ATOM   760  H HB3    . LEU A 1 53  ? 18.10500 -6.24100  -24.95400 1.000 82.10000  ? 53  LEU A HB3    1 
ATOM   761  H HG     . LEU A 1 53  ? 19.20900 -8.20700  -23.29000 1.000 95.15000  ? 53  LEU A HG     1 
ATOM   762  H HD11   . LEU A 1 53  ? 17.14200 -9.28800  -23.22700 1.000 93.20000  ? 53  LEU A HD11   1 
ATOM   763  H HD12   . LEU A 1 53  ? 17.11100 -7.91500  -22.42800 1.000 93.20000  ? 53  LEU A HD12   1 
ATOM   764  H HD13   . LEU A 1 53  ? 16.47000 -8.00500  -23.87900 1.000 93.20000  ? 53  LEU A HD13   1 
ATOM   765  H HD21   . LEU A 1 53  ? 18.66200 -9.61400  -25.11200 1.000 107.90000 ? 53  LEU A HD21   1 
ATOM   766  H HD22   . LEU A 1 53  ? 18.05400 -8.36600  -25.88400 1.000 107.90000 ? 53  LEU A HD22   1 
ATOM   767  H HD23   . LEU A 1 53  ? 19.61500 -8.44000  -25.59800 1.000 107.90000 ? 53  LEU A HD23   1 
ATOM   768  N N      . SER A 1 54  ? 19.39700 -3.51500  -24.88300 1.000 55.53000  ? 54  SER A N      1 
ATOM   769  C CA     . SER A 1 54  ? 19.38600 -2.31600  -25.70900 1.000 51.34000  ? 54  SER A CA     1 
ATOM   770  C C      . SER A 1 54  ? 20.78700 -1.72200  -25.86000 1.000 70.59000  ? 54  SER A C      1 
ATOM   771  O O      . SER A 1 54  ? 21.18400 -1.37700  -26.97100 1.000 73.59000  ? 54  SER A O      1 
ATOM   772  C CB     . SER A 1 54  ? 18.40900 -1.31300  -25.08800 1.000 63.53000  ? 54  SER A CB     1 
ATOM   773  O OG     . SER A 1 54  ? 18.56500 -0.02200  -25.59700 1.000 87.62000  ? 54  SER A OG     1 
ATOM   774  H H      . SER A 1 54  ? 19.02400 -3.41800  -24.11500 1.000 67.02000  ? 54  SER A H      1 
ATOM   775  H HA     . SER A 1 54  ? 19.08100 -2.53100  -26.60500 1.000 61.99000  ? 54  SER A HA     1 
ATOM   776  H HB2    . SER A 1 54  ? 17.50400 -1.61000  -25.27100 1.000 76.61000  ? 54  SER A HB2    1 
ATOM   777  H HB3    . SER A 1 54  ? 18.56200 -1.28700  -24.13000 1.000 76.61000  ? 54  SER A HB3    1 
ATOM   778  H HG     . SER A 1 54  ? 17.89100 0.44400   -25.41100 1.000 105.53000 ? 54  SER A HG     1 
ATOM   779  N N      . ASP A 1 55  ? 21.57100 -1.63300  -24.77600 1.000 67.15000  ? 55  ASP A N      1 
ATOM   780  C CA     . ASP A 1 55  ? 22.84100 -0.89700  -24.78400 1.000 48.88000  ? 55  ASP A CA     1 
ATOM   781  C C      . ASP A 1 55  ? 23.94500 -1.67200  -24.05400 1.000 52.62000  ? 55  ASP A C      1 
ATOM   782  O O      . ASP A 1 55  ? 24.17100 -1.51000  -22.84500 1.000 49.31000  ? 55  ASP A O      1 
ATOM   783  C CB     . ASP A 1 55  ? 22.65400 0.49400   -24.16500 1.000 46.45000  ? 55  ASP A CB     1 
ATOM   784  C CG     . ASP A 1 55  ? 23.95500 1.29700   -24.08100 1.000 61.00000  ? 55  ASP A CG     1 
ATOM   785  O OD1    . ASP A 1 55  ? 25.03300 0.79400   -24.56500 1.000 52.13000  ? 55  ASP A OD1    1 
ATOM   786  O OD2    . ASP A 1 55  ? 23.88500 2.43800   -23.53300 1.000 50.33000  ? 55  ASP A OD2    1 
ATOM   787  H H      . ASP A 1 55  ? 21.38500 -1.99300  -24.01700 1.000 80.96000  ? 55  ASP A H      1 
ATOM   788  H HA     . ASP A 1 55  ? 23.13300 -0.81600  -25.70600 1.000 59.04000  ? 55  ASP A HA     1 
ATOM   789  H HB2    . ASP A 1 55  ? 22.02800 0.99800   -24.70800 1.000 56.12000  ? 55  ASP A HB2    1 
ATOM   790  H HB3    . ASP A 1 55  ? 22.30800 0.39300   -23.26500 1.000 56.12000  ? 55  ASP A HB3    1 
ATOM   791  N N      . PRO A 1 56  ? 24.70200 -2.47000  -24.79300 1.000 62.31000  ? 56  PRO A N      1 
ATOM   792  C CA     . PRO A 1 56  ? 25.71000 -3.32600  -24.13300 1.000 49.87000  ? 56  PRO A CA     1 
ATOM   793  C C      . PRO A 1 56  ? 26.82700 -2.59300  -23.39000 1.000 54.63000  ? 56  PRO A C      1 
ATOM   794  O O      . PRO A 1 56  ? 27.49200 -3.21100  -22.55000 1.000 56.55000  ? 56  PRO A O      1 
ATOM   795  C CB     . PRO A 1 56  ? 26.31200 -4.14300  -25.27900 1.000 45.88000  ? 56  PRO A CB     1 
ATOM   796  C CG     . PRO A 1 56  ? 25.31900 -3.99200  -26.48500 1.000 43.63000  ? 56  PRO A CG     1 
ATOM   797  C CD     . PRO A 1 56  ? 24.41200 -2.83100  -26.20300 1.000 66.20000  ? 56  PRO A CD     1 
ATOM   798  H HA     . PRO A 1 56  ? 25.23500 -3.89900  -23.51000 1.000 60.22000  ? 56  PRO A HA     1 
ATOM   799  H HB2    . PRO A 1 56  ? 27.18600 -3.78900  -25.50700 1.000 55.43000  ? 56  PRO A HB2    1 
ATOM   800  H HB3    . PRO A 1 56  ? 26.38900 -5.07200  -25.01200 1.000 55.43000  ? 56  PRO A HB3    1 
ATOM   801  H HG2    . PRO A 1 56  ? 25.82700 -3.83100  -27.29600 1.000 52.74000  ? 56  PRO A HG2    1 
ATOM   802  H HG3    . PRO A 1 56  ? 24.80100 -4.80700  -26.57400 1.000 52.74000  ? 56  PRO A HG3    1 
ATOM   803  H HD2    . PRO A 1 56  ? 24.61500 -2.08900  -26.79300 1.000 79.83000  ? 56  PRO A HD2    1 
ATOM   804  H HD3    . PRO A 1 56  ? 23.48300 -3.09100  -26.30400 1.000 79.83000  ? 56  PRO A HD3    1 
ATOM   805  N N      . SER A 1 57  ? 27.09500 -1.32500  -23.66900 1.000 50.30000  ? 57  SER A N      1 
ATOM   806  C CA     . SER A 1 57  ? 28.15600 -0.65200  -22.92200 1.000 73.42000  ? 57  SER A CA     1 
ATOM   807  C C      . SER A 1 57  ? 27.81200 -0.50800  -21.42800 1.000 50.15000  ? 57  SER A C      1 
ATOM   808  O O      . SER A 1 57  ? 28.72100 -0.26800  -20.63300 1.000 44.53000  ? 57  SER A O      1 
ATOM   809  C CB     . SER A 1 57  ? 28.46500 0.71600   -23.55200 1.000 41.05000  ? 57  SER A CB     1 
ATOM   810  O OG     . SER A 1 57  ? 27.40700 1.62800   -23.32600 1.000 58.37000  ? 57  SER A OG     1 
ATOM   811  H H      . SER A 1 57  ? 26.69600 -0.84800  -24.26300 1.000 60.74000  ? 57  SER A H      1 
ATOM   812  H HA     . SER A 1 57  ? 28.96800 -1.17900  -22.97900 1.000 88.48000  ? 57  SER A HA     1 
ATOM   813  H HB2    . SER A 1 57  ? 29.27600 1.06900   -23.15700 1.000 49.64000  ? 57  SER A HB2    1 
ATOM   814  H HB3    . SER A 1 57  ? 28.58400 0.60200   -24.50800 1.000 49.64000  ? 57  SER A HB3    1 
ATOM   815  H HG     . SER A 1 57  ? 26.68900 1.31800   -23.63100 1.000 70.43000  ? 57  SER A HG     1 
ATOM   816  N N      . GLN A 1 58  ? 26.53200 -0.64400  -21.05000 1.000 35.67000  ? 58  GLN A N      1 
ATOM   817  C CA     . GLN A 1 58  ? 26.11200 -0.50300  -19.66000 1.000 53.30000  ? 58  GLN A CA     1 
ATOM   818  C C      . GLN A 1 58  ? 26.80400 -1.50900  -18.75100 1.000 45.70000  ? 58  GLN A C      1 
ATOM   819  O O      . GLN A 1 58  ? 26.89400 -1.27900  -17.53700 1.000 44.56000  ? 58  GLN A O      1 
ATOM   820  C CB     . GLN A 1 58  ? 24.60400 -0.70800  -19.51800 1.000 44.83000  ? 58  GLN A CB     1 
ATOM   821  C CG     . GLN A 1 58  ? 23.76100 0.34800   -20.17200 1.000 48.97000  ? 58  GLN A CG     1 
ATOM   822  C CD     . GLN A 1 58  ? 24.18500 1.71300   -19.72800 1.000 50.21000  ? 58  GLN A CD     1 
ATOM   823  O OE1    . GLN A 1 58  ? 24.01100 2.05100   -18.55400 1.000 55.49000  ? 58  GLN A OE1    1 
ATOM   824  N NE2    . GLN A 1 58  ? 24.77100 2.51200   -20.64800 1.000 47.65000  ? 58  GLN A NE2    1 
ATOM   825  H H      . GLN A 1 58  ? 25.88400 -0.82000  -21.58800 1.000 43.18000  ? 58  GLN A H      1 
ATOM   826  H HA     . GLN A 1 58  ? 26.34100 0.39900   -19.38500 1.000 64.34000  ? 58  GLN A HA     1 
ATOM   827  H HB2    . GLN A 1 58  ? 24.37000 -1.55900  -19.92100 1.000 54.18000  ? 58  GLN A HB2    1 
ATOM   828  H HB3    . GLN A 1 58  ? 24.38200 -0.71500  -18.57400 1.000 54.18000  ? 58  GLN A HB3    1 
ATOM   829  H HG2    . GLN A 1 58  ? 23.86100 0.29100   -21.13500 1.000 59.14000  ? 58  GLN A HG2    1 
ATOM   830  H HG3    . GLN A 1 58  ? 22.83200 0.21800   -19.92700 1.000 59.14000  ? 58  GLN A HG3    1 
ATOM   831  H HE21   . GLN A 1 58  ? 24.88700 2.23000   -21.45200 1.000 57.57000  ? 58  GLN A HE21   1 
ATOM   832  H HE22   . GLN A 1 58  ? 25.02800 3.30300   -20.42900 1.000 57.57000  ? 58  GLN A HE22   1 
ATOM   833  N N      . LEU A 1 59  ? 27.24300 -2.63800  -19.29800 1.000 47.50000  ? 59  LEU A N      1 
ATOM   834  C CA     . LEU A 1 59  ? 27.87900 -3.66400  -18.49400 1.000 49.75000  ? 59  LEU A CA     1 
ATOM   835  C C      . LEU A 1 59  ? 29.37500 -3.45100  -18.28300 1.000 46.14000  ? 59  LEU A C      1 
ATOM   836  O O      . LEU A 1 59  ? 30.03500 -4.28500  -17.63200 1.000 56.26000  ? 59  LEU A O      1 
ATOM   837  C CB     . LEU A 1 59  ? 27.70700 -5.03200  -19.12800 1.000 35.33000  ? 59  LEU A CB     1 
ATOM   838  C CG     . LEU A 1 59  ? 26.29000 -5.63800  -19.16000 1.000 38.51000  ? 59  LEU A CG     1 
ATOM   839  C CD1    . LEU A 1 59  ? 26.34100 -7.03000  -19.80700 1.000 38.72000  ? 59  LEU A CD1    1 
ATOM   840  C CD2    . LEU A 1 59  ? 25.71000 -5.67100  -17.76400 1.000 58.54000  ? 59  LEU A CD2    1 
ATOM   841  H H      . LEU A 1 59  ? 27.18100 -2.82900  -20.13500 1.000 57.38000  ? 59  LEU A H      1 
ATOM   842  H HA     . LEU A 1 59  ? 27.43600 -3.64900  -17.63200 1.000 60.09000  ? 59  LEU A HA     1 
ATOM   843  H HB2    . LEU A 1 59  ? 28.00500 -4.97000  -20.04900 1.000 42.78000  ? 59  LEU A HB2    1 
ATOM   844  H HB3    . LEU A 1 59  ? 28.26700 -5.65500  -18.64000 1.000 42.78000  ? 59  LEU A HB3    1 
ATOM   845  H HG     . LEU A 1 59  ? 25.69500 -5.09200  -19.69800 1.000 46.60000  ? 59  LEU A HG     1 
ATOM   846  H HD11   . LEU A 1 59  ? 25.45800 -7.42900  -19.76900 1.000 46.85000  ? 59  LEU A HD11   1 
ATOM   847  H HD12   . LEU A 1 59  ? 26.62300 -6.93800  -20.73100 1.000 46.85000  ? 59  LEU A HD12   1 
ATOM   848  H HD13   . LEU A 1 59  ? 26.97400 -7.58100  -19.32100 1.000 46.85000  ? 59  LEU A HD13   1 
ATOM   849  H HD21   . LEU A 1 59  ? 24.86300 -6.14400  -17.78500 1.000 70.63000  ? 59  LEU A HD21   1 
ATOM   850  H HD22   . LEU A 1 59  ? 26.33000 -6.12900  -17.17500 1.000 70.63000  ? 59  LEU A HD22   1 
ATOM   851  H HD23   . LEU A 1 59  ? 25.57300 -4.76100  -17.45700 1.000 70.63000  ? 59  LEU A HD23   1 
ATOM   852  N N      . GLU A 1 60  ? 29.93900 -2.38800  -18.84200 1.000 47.02000  ? 60  GLU A N      1 
ATOM   853  C CA     . GLU A 1 60  ? 31.39400 -2.24000  -18.83300 1.000 56.32000  ? 60  GLU A CA     1 
ATOM   854  C C      . GLU A 1 60  ? 31.93900 -1.80000  -17.47300 1.000 42.57000  ? 60  GLU A C      1 
ATOM   855  O O      . GLU A 1 60  ? 33.11900 -2.03300  -17.19200 1.000 46.09000  ? 60  GLU A O      1 
ATOM   856  C CB     . GLU A 1 60  ? 31.85200 -1.23800  -19.89400 1.000 54.48000  ? 60  GLU A CB     1 
ATOM   857  C CG     . GLU A 1 60  ? 32.12700 -1.84300  -21.25600 1.000 50.07000  ? 60  GLU A CG     1 
ATOM   858  C CD     . GLU A 1 60  ? 31.92500 -0.82800  -22.42400 1.000 76.42000  ? 60  GLU A CD     1 
ATOM   859  O OE1    . GLU A 1 60  ? 31.76800 0.39300   -22.18500 1.000 70.51000  ? 60  GLU A OE1    1 
ATOM   860  O OE2    . GLU A 1 60  ? 31.90400 -1.27800  -23.58600 1.000 78.26000  ? 60  GLU A OE2    1 
ATOM   861  H H      . GLU A 1 60  ? 29.51200 -1.74800  -19.22700 1.000 56.81000  ? 60  GLU A H      1 
ATOM   862  H HA     . GLU A 1 60  ? 31.77600 -3.10400  -19.05500 1.000 67.97000  ? 60  GLU A HA     1 
ATOM   863  H HB2    . GLU A 1 60  ? 31.15900 -0.56800  -20.00500 1.000 65.76000  ? 60  GLU A HB2    1 
ATOM   864  H HB3    . GLU A 1 60  ? 32.67200 -0.81900  -19.58900 1.000 65.76000  ? 60  GLU A HB3    1 
ATOM   865  H HG2    . GLU A 1 60  ? 33.04600 -2.15300  -21.28400 1.000 60.46000  ? 60  GLU A HG2    1 
ATOM   866  H HG3    . GLU A 1 60  ? 31.52100 -2.58700  -21.39800 1.000 60.46000  ? 60  GLU A HG3    1 
ATOM   867  N N      . SER A 1 61  ? 31.08500 -1.22300  -16.62000 1.000 49.46000  ? 61  SER A N      1 
ATOM   868  C CA     . SER A 1 61  ? 31.44200 -0.82500  -15.26300 1.000 40.39000  ? 61  SER A CA     1 
ATOM   869  C C      . SER A 1 61  ? 31.73800 -2.01900  -14.34600 1.000 35.64000  ? 61  SER A C      1 
ATOM   870  O O      . SER A 1 61  ? 32.45100 -1.83900  -13.35400 1.000 42.71000  ? 61  SER A O      1 
ATOM   871  C CB     . SER A 1 61  ? 30.29300 0.03500   -14.70100 1.000 39.99000  ? 61  SER A CB     1 
ATOM   872  O OG     . SER A 1 61  ? 29.04700 -0.62700  -15.04200 1.000 38.13000  ? 61  SER A OG     1 
ATOM   873  H H      . SER A 1 61  ? 30.26600 -1.04600  -16.81300 1.000 59.74000  ? 61  SER A H      1 
ATOM   874  H HA     . SER A 1 61  ? 32.25300 -0.29400  -15.27500 1.000 48.85000  ? 61  SER A HA     1 
ATOM   875  H HB2    . SER A 1 61  ? 30.37600 0.10600   -13.73700 1.000 48.37000  ? 61  SER A HB2    1 
ATOM   876  H HB3    . SER A 1 61  ? 30.31700 0.91800   -15.10200 1.000 48.37000  ? 61  SER A HB3    1 
ATOM   877  H HG     . SER A 1 61  ? 28.40000 -0.11000  -14.90200 1.000 46.13000  ? 61  SER A HG     1 
ATOM   878  N N      . GLU A 1 62  ? 31.22000 -3.19200  -14.64200 1.000 32.29000  ? 62  GLU A N      1 
ATOM   879  C CA     . GLU A 1 62  ? 31.36700 -4.45400  -13.92500 1.000 44.10000  ? 62  GLU A CA     1 
ATOM   880  C C      . GLU A 1 62  ? 30.85400 -5.58400  -14.82300 1.000 39.95000  ? 62  GLU A C      1 
ATOM   881  O O      . GLU A 1 62  ? 29.67600 -5.95000  -14.74200 1.000 44.37000  ? 62  GLU A O      1 
ATOM   882  C CB     . GLU A 1 62  ? 30.59500 -4.43600  -12.60700 1.000 38.08000  ? 62  GLU A CB     1 
ATOM   883  C CG     . GLU A 1 62  ? 30.76900 -5.75300  -11.79800 1.000 45.46000  ? 62  GLU A CG     1 
ATOM   884  C CD     . GLU A 1 62  ? 32.20100 -6.13900  -11.65600 1.000 63.62000  ? 62  GLU A CD     1 
ATOM   885  O OE1    . GLU A 1 62  ? 32.88300 -5.40200  -10.89400 1.000 45.93000  ? 62  GLU A OE1    1 
ATOM   886  O OE2    . GLU A 1 62  ? 32.64800 -7.08100  -12.37500 1.000 65.63000  ? 62  GLU A OE2    1 
ATOM   887  H H      . GLU A 1 62  ? 30.72000 -3.30400  -15.33300 1.000 39.13000  ? 62  GLU A H      1 
ATOM   888  H HA     . GLU A 1 62  ? 32.30100 -4.60400  -13.71100 1.000 53.30000  ? 62  GLU A HA     1 
ATOM   889  H HB2    . GLU A 1 62  ? 30.91800 -3.70200  -12.06100 1.000 46.08000  ? 62  GLU A HB2    1 
ATOM   890  H HB3    . GLU A 1 62  ? 29.65100 -4.31900  -12.79400 1.000 46.08000  ? 62  GLU A HB3    1 
ATOM   891  H HG2    . GLU A 1 62  ? 30.39800 -5.63200  -10.90900 1.000 54.93000  ? 62  GLU A HG2    1 
ATOM   892  H HG3    . GLU A 1 62  ? 30.30500 -6.47100  -12.25600 1.000 54.93000  ? 62  GLU A HG3    1 
ATOM   893  N N      . PRO A 1 63  ? 31.68300 -6.13600  -15.69800 1.000 50.08000  ? 63  PRO A N      1 
ATOM   894  C CA     . PRO A 1 63  ? 31.16400 -7.05300  -16.72400 1.000 40.89000  ? 63  PRO A CA     1 
ATOM   895  C C      . PRO A 1 63  ? 30.59200 -8.36600  -16.19800 1.000 42.89000  ? 63  PRO A C      1 
ATOM   896  O O      . PRO A 1 63  ? 29.77800 -8.99200  -16.89000 1.000 44.81000  ? 63  PRO A O      1 
ATOM   897  C CB     . PRO A 1 63  ? 32.40200 -7.32500  -17.61400 1.000 36.79000  ? 63  PRO A CB     1 
ATOM   898  C CG     . PRO A 1 63  ? 33.27300 -6.12000  -17.43200 1.000 44.23000  ? 63  PRO A CG     1 
ATOM   899  C CD     . PRO A 1 63  ? 33.00900 -5.59500  -16.02800 1.000 52.14000  ? 63  PRO A CD     1 
ATOM   900  H HA     . PRO A 1 63  ? 30.47200 -6.58900  -17.22100 1.000 49.45000  ? 63  PRO A HA     1 
ATOM   901  H HB2    . PRO A 1 63  ? 32.85400 -8.13000  -17.31700 1.000 44.53000  ? 63  PRO A HB2    1 
ATOM   902  H HB3    . PRO A 1 63  ? 32.13000 -7.42100  -18.54000 1.000 44.53000  ? 63  PRO A HB3    1 
ATOM   903  H HG2    . PRO A 1 63  ? 34.20300 -6.37600  -17.53000 1.000 53.46000  ? 63  PRO A HG2    1 
ATOM   904  H HG3    . PRO A 1 63  ? 33.04100 -5.45100  -18.09400 1.000 53.46000  ? 63  PRO A HG3    1 
ATOM   905  H HD2    . PRO A 1 63  ? 33.67800 -5.92300  -15.40700 1.000 62.95000  ? 63  PRO A HD2    1 
ATOM   906  H HD3    . PRO A 1 63  ? 32.99600 -4.62500  -16.02000 1.000 62.95000  ? 63  PRO A HD3    1 
ATOM   907  N N      . GLU A 1 64  ? 31.07100 -8.86900  -15.07400 1.000 50.24000  ? 64  GLU A N      1 
ATOM   908  C CA     . GLU A 1 64  ? 30.53800 -10.10000 -14.53800 1.000 40.14000  ? 64  GLU A CA     1 
ATOM   909  C C      . GLU A 1 64  ? 29.25900 -9.79600  -13.77700 1.000 46.20000  ? 64  GLU A C      1 
ATOM   910  O O      . GLU A 1 64  ? 29.15400 -8.78000  -13.07900 1.000 43.53000  ? 64  GLU A O      1 
ATOM   911  C CB     . GLU A 1 64  ? 31.55300 -10.76000 -13.63700 1.000 41.96000  ? 64  GLU A CB     1 
ATOM   912  C CG     . GLU A 1 64  ? 32.29000 -11.87800 -14.32700 1.000 71.63000  ? 64  GLU A CG     1 
ATOM   913  C CD     . GLU A 1 64  ? 33.02400 -11.39400 -15.57700 1.000 83.31000  ? 64  GLU A CD     1 
ATOM   914  O OE1    . GLU A 1 64  ? 34.02900 -10.64000 -15.43900 1.000 69.33000  ? 64  GLU A OE1    1 
ATOM   915  O OE2    . GLU A 1 64  ? 32.59000 -11.76200 -16.70600 1.000 75.16000  ? 64  GLU A OE2    1 
ATOM   916  H H      . GLU A 1 64  ? 31.70100 -8.51600  -14.60700 1.000 60.67000  ? 64  GLU A H      1 
ATOM   917  H HA     . GLU A 1 64  ? 30.33400 -10.72500 -15.25000 1.000 48.55000  ? 64  GLU A HA     1 
ATOM   918  H HB2    . GLU A 1 64  ? 32.20400 -10.09900 -13.35500 1.000 50.74000  ? 64  GLU A HB2    1 
ATOM   919  H HB3    . GLU A 1 64  ? 31.09800 -11.13000 -12.86400 1.000 50.74000  ? 64  GLU A HB3    1 
ATOM   920  H HG2    . GLU A 1 64  ? 32.94400 -12.25200 -13.71700 1.000 86.34000  ? 64  GLU A HG2    1 
ATOM   921  H HG3    . GLU A 1 64  ? 31.65500 -12.56200 -14.59300 1.000 86.34000  ? 64  GLU A HG3    1 
ATOM   922  N N      . LEU A 1 65  ? 28.27400 -10.66400 -13.94900 1.000 37.38000  ? 65  LEU A N      1 
ATOM   923  C CA     . LEU A 1 65  ? 26.97000 -10.56000 -13.30500 1.000 34.12000  ? 65  LEU A CA     1 
ATOM   924  C C      . LEU A 1 65  ? 26.91000 -11.61900 -12.22800 1.000 38.89000  ? 65  LEU A C      1 
ATOM   925  O O      . LEU A 1 65  ? 26.85900 -12.81200 -12.53200 1.000 41.78000  ? 65  LEU A O      1 
ATOM   926  C CB     . LEU A 1 65  ? 25.83200 -10.77400 -14.28800 1.000 37.69000  ? 65  LEU A CB     1 
ATOM   927  C CG     . LEU A 1 65  ? 25.75800 -9.75200  -15.38500 1.000 49.23000  ? 65  LEU A CG     1 
ATOM   928  C CD1    . LEU A 1 65  ? 24.57600 -10.13100 -16.27800 1.000 45.17000  ? 65  LEU A CD1    1 
ATOM   929  C CD2    . LEU A 1 65  ? 25.60100 -8.38800  -14.81200 1.000 37.68000  ? 65  LEU A CD2    1 
ATOM   930  H H      . LEU A 1 65  ? 28.33800 -11.35300 -14.45900 1.000 45.24000  ? 65  LEU A H      1 
ATOM   931  H HA     . LEU A 1 65  ? 26.88400 -9.67400  -12.91800 1.000 41.32000  ? 65  LEU A HA     1 
ATOM   932  H HB2    . LEU A 1 65  ? 25.94300 -11.64400 -14.70300 1.000 45.61000  ? 65  LEU A HB2    1 
ATOM   933  H HB3    . LEU A 1 65  ? 24.99400 -10.74400 -13.80100 1.000 45.61000  ? 65  LEU A HB3    1 
ATOM   934  H HG     . LEU A 1 65  ? 26.57200 -9.73400  -15.91300 1.000 59.46000  ? 65  LEU A HG     1 
ATOM   935  H HD11   . LEU A 1 65  ? 24.48700 -9.46900  -16.98200 1.000 54.58000  ? 65  LEU A HD11   1 
ATOM   936  H HD12   . LEU A 1 65  ? 24.74100 -11.00500 -16.66600 1.000 54.58000  ? 65  LEU A HD12   1 
ATOM   937  H HD13   . LEU A 1 65  ? 23.76900 -10.15400 -15.74100 1.000 54.58000  ? 65  LEU A HD13   1 
ATOM   938  H HD21   . LEU A 1 65  ? 25.40200 -7.76600  -15.52900 1.000 45.60000  ? 65  LEU A HD21   1 
ATOM   939  H HD22   . LEU A 1 65  ? 24.87400 -8.39600  -14.17000 1.000 45.60000  ? 65  LEU A HD22   1 
ATOM   940  H HD23   . LEU A 1 65  ? 26.42700 -8.13300  -14.37200 1.000 45.60000  ? 65  LEU A HD23   1 
ATOM   941  N N      . PHE A 1 66  ? 26.85800 -11.19700 -10.97700 1.000 38.33000  ? 66  PHE A N      1 
ATOM   942  C CA     . PHE A 1 66  ? 26.96300 -12.15200 -9.87900  1.000 34.42000  ? 66  PHE A CA     1 
ATOM   943  C C      . PHE A 1 66  ? 26.23600 -11.61600 -8.65700  1.000 36.92000  ? 66  PHE A C      1 
ATOM   944  O O      . PHE A 1 66  ? 25.99800 -10.40800 -8.52100  1.000 34.65000  ? 66  PHE A O      1 
ATOM   945  C CB     . PHE A 1 66  ? 28.46000 -12.42900 -9.50700  1.000 32.31000  ? 66  PHE A CB     1 
ATOM   946  C CG     . PHE A 1 66  ? 29.19000 -11.18100 -9.10400  1.000 30.25000  ? 66  PHE A CG     1 
ATOM   947  C CD1    . PHE A 1 66  ? 29.13000 -10.72700 -7.78800  1.000 32.24000  ? 66  PHE A CD1    1 
ATOM   948  C CD2    . PHE A 1 66  ? 29.86200 -10.41700 -10.03900 1.000 30.68000  ? 66  PHE A CD2    1 
ATOM   949  C CE1    . PHE A 1 66  ? 29.71600 -9.54900  -7.43300  1.000 45.22000  ? 66  PHE A CE1    1 
ATOM   950  C CE2    . PHE A 1 66  ? 30.46500 -9.27300  -9.68400  1.000 40.14000  ? 66  PHE A CE2    1 
ATOM   951  C CZ     . PHE A 1 66  ? 30.37800 -8.81700  -8.37600  1.000 39.02000  ? 66  PHE A CZ     1 
ATOM   952  H H      . PHE A 1 66  ? 26.76300 -10.37700 -10.73800 1.000 46.37000  ? 66  PHE A H      1 
ATOM   953  H HA     . PHE A 1 66  ? 26.53600 -12.98000 -10.14900 1.000 41.69000  ? 66  PHE A HA     1 
ATOM   954  H HB2    . PHE A 1 66  ? 28.49300 -13.05100 -8.76300  1.000 39.15000  ? 66  PHE A HB2    1 
ATOM   955  H HB3    . PHE A 1 66  ? 28.91300 -12.80800 -10.27700 1.000 39.15000  ? 66  PHE A HB3    1 
ATOM   956  H HD1    . PHE A 1 66  ? 28.68500 -11.23300 -7.14700  1.000 39.06000  ? 66  PHE A HD1    1 
ATOM   957  H HD2    . PHE A 1 66  ? 29.89700 -10.70000 -10.92400 1.000 37.20000  ? 66  PHE A HD2    1 
ATOM   958  H HE1    . PHE A 1 66  ? 29.66500 -9.24700  -6.55500  1.000 54.65000  ? 66  PHE A HE1    1 
ATOM   959  H HE2    . PHE A 1 66  ? 30.94300 -8.78400  -10.31600 1.000 48.55000  ? 66  PHE A HE2    1 
ATOM   960  H HZ     . PHE A 1 66  ? 30.77200 -8.00900  -8.14000  1.000 47.20000  ? 66  PHE A HZ     1 
ATOM   961  N N      . ILE A 1 67  ? 25.93600 -12.54400 -7.75200  1.000 32.32000  ? 67  ILE A N      1 
ATOM   962  C CA     . ILE A 1 67  ? 25.59700 -12.29200 -6.35800  1.000 44.88000  ? 67  ILE A CA     1 
ATOM   963  C C      . ILE A 1 67  ? 26.65800 -12.93000 -5.47700  1.000 36.22000  ? 67  ILE A C      1 
ATOM   964  O O      . ILE A 1 67  ? 27.04300 -14.08500 -5.68000  1.000 37.40000  ? 67  ILE A O      1 
ATOM   965  C CB     . ILE A 1 67  ? 24.22500 -12.89500 -6.05600  1.000 27.88000  ? 67  ILE A CB     1 
ATOM   966  C CG1    . ILE A 1 67  ? 23.18500 -12.30800 -6.97800  1.000 36.05000  ? 67  ILE A CG1    1 
ATOM   967  C CG2    . ILE A 1 67  ? 23.84900 -12.67600 -4.58500  1.000 24.87000  ? 67  ILE A CG2    1 
ATOM   968  C CD1    . ILE A 1 67  ? 22.04200 -13.25300 -7.08900  1.000 32.76000  ? 67  ILE A CD1    1 
ATOM   969  H H      . ILE A 1 67  ? 25.92300 -13.38400 -7.93700  1.000 39.17000  ? 67  ILE A H      1 
ATOM   970  H HA     . ILE A 1 67  ? 25.58900 -11.33900 -6.17900  1.000 54.24000  ? 67  ILE A HA     1 
ATOM   971  H HB     . ILE A 1 67  ? 24.26600 -13.85100 -6.21300  1.000 33.84000  ? 67  ILE A HB     1 
ATOM   972  H HG12   . ILE A 1 67  ? 22.86400 -11.46600 -6.61900  1.000 43.64000  ? 67  ILE A HG12   1 
ATOM   973  H HG13   . ILE A 1 67  ? 23.56600 -12.16900 -7.85900  1.000 43.64000  ? 67  ILE A HG13   1 
ATOM   974  H HG21   . ILE A 1 67  ? 22.94800 -13.00400 -4.43700  1.000 30.22000  ? 67  ILE A HG21   1 
ATOM   975  H HG22   . ILE A 1 67  ? 24.47400 -13.16200 -4.02400  1.000 30.22000  ? 67  ILE A HG22   1 
ATOM   976  H HG23   . ILE A 1 67  ? 23.89300 -11.72800 -4.38500  1.000 30.22000  ? 67  ILE A HG23   1 
ATOM   977  H HD11   . ILE A 1 67  ? 21.51200 -13.01800 -7.86700  1.000 39.70000  ? 67  ILE A HD11   1 
ATOM   978  H HD12   . ILE A 1 67  ? 22.38600 -14.15500 -7.18400  1.000 39.70000  ? 67  ILE A HD12   1 
ATOM   979  H HD13   . ILE A 1 67  ? 21.50000 -13.18800 -6.28700  1.000 39.70000  ? 67  ILE A HD13   1 
ATOM   980  N N      . ARG A 1 68  ? 27.12700 -12.18000 -4.50200  1.000 39.38000  ? 68  ARG A N      1 
ATOM   981  C CA     . ARG A 1 68  ? 28.28700 -12.62000 -3.73200  1.000 37.51000  ? 68  ARG A CA     1 
ATOM   982  C C      . ARG A 1 68  ? 28.04000 -12.35900 -2.25800  1.000 41.37000  ? 68  ARG A C      1 
ATOM   983  O O      . ARG A 1 68  ? 27.60600 -11.27700 -1.87300  1.000 40.20000  ? 68  ARG A O      1 
ATOM   984  C CB     . ARG A 1 68  ? 29.54200 -11.90600 -4.20200  1.000 30.04000  ? 68  ARG A CB     1 
ATOM   985  C CG     . ARG A 1 68  ? 30.85300 -12.52400 -3.80100  1.000 39.60000  ? 68  ARG A CG     1 
ATOM   986  C CD     . ARG A 1 68  ? 32.04800 -11.72400 -4.36500  1.000 36.01000  ? 68  ARG A CD     1 
ATOM   987  N NE     . ARG A 1 68  ? 32.16400 -11.83900 -5.81300  1.000 33.84000  ? 68  ARG A NE     1 
ATOM   988  C CZ     . ARG A 1 68  ? 32.83000 -10.99300 -6.57100  1.000 40.61000  ? 68  ARG A CZ     1 
ATOM   989  N NH1    . ARG A 1 68  ? 33.48100 -9.97300  -6.04100  1.000 42.32000  ? 68  ARG A NH1    1 
ATOM   990  N NH2    . ARG A 1 68  ? 32.84300 -11.18800 -7.88800  1.000 35.62000  ? 68  ARG A NH2    1 
ATOM   991  H H      . ARG A 1 68  ? 26.80000 -11.42100 -4.26500  1.000 47.63000  ? 68  ARG A H      1 
ATOM   992  H HA     . ARG A 1 68  ? 28.41500 -13.57500 -3.84200  1.000 45.39000  ? 68  ARG A HA     1 
ATOM   993  H HB2    . ARG A 1 68  ? 29.52600 -11.87600 -5.17100  1.000 36.43000  ? 68  ARG A HB2    1 
ATOM   994  H HB3    . ARG A 1 68  ? 29.53000 -11.00600 -3.84100  1.000 36.43000  ? 68  ARG A HB3    1 
ATOM   995  H HG2    . ARG A 1 68  ? 30.92200 -12.53400 -2.83300  1.000 47.91000  ? 68  ARG A HG2    1 
ATOM   996  H HG3    . ARG A 1 68  ? 30.90100 -13.43000 -4.14600  1.000 47.91000  ? 68  ARG A HG3    1 
ATOM   997  H HD2    . ARG A 1 68  ? 31.93400 -10.78600 -4.14600  1.000 43.60000  ? 68  ARG A HD2    1 
ATOM   998  H HD3    . ARG A 1 68  ? 32.86900 -12.06000 -3.97100  1.000 43.60000  ? 68  ARG A HD3    1 
ATOM   999  H HE     . ARG A 1 68  ? 31.77200 -12.50100 -6.19700  1.000 40.99000  ? 68  ARG A HE     1 
ATOM   1000 H HH11   . ARG A 1 68  ? 33.47300 -9.85300  -5.18900  1.000 51.17000  ? 68  ARG A HH11   1 
ATOM   1001 H HH12   . ARG A 1 68  ? 33.91200 -9.42800  -6.54800  1.000 51.17000  ? 68  ARG A HH12   1 
ATOM   1002 H HH21   . ARG A 1 68  ? 32.42100 -11.85500 -8.22900  1.000 43.13000  ? 68  ARG A HH21   1 
ATOM   1003 H HH22   . ARG A 1 68  ? 33.27300 -10.64500 -8.39900  1.000 43.13000  ? 68  ARG A HH22   1 
ATOM   1004 N N      . ILE A 1 69  ? 28.26300 -13.38300 -1.45700  1.000 33.15000  ? 69  ILE A N      1 
ATOM   1005 C CA     . ILE A 1 69  ? 28.03100 -13.38100 -0.01900  1.000 38.17000  ? 69  ILE A CA     1 
ATOM   1006 C C      . ILE A 1 69  ? 29.38600 -13.43100 0.66300   1.000 35.74000  ? 69  ILE A C      1 
ATOM   1007 O O      . ILE A 1 69  ? 30.18700 -14.33800 0.38300   1.000 34.26000  ? 69  ILE A O      1 
ATOM   1008 C CB     . ILE A 1 69  ? 27.16600 -14.57700 0.40000   1.000 31.99000  ? 69  ILE A CB     1 
ATOM   1009 C CG1    . ILE A 1 69  ? 25.88700 -14.56800 -0.43400  1.000 36.96000  ? 69  ILE A CG1    1 
ATOM   1010 C CG2    . ILE A 1 69  ? 26.89500 -14.57000 1.88600   1.000 42.32000  ? 69  ILE A CG2    1 
ATOM   1011 C CD1    . ILE A 1 69  ? 25.05500 -15.84400 -0.24800  1.000 43.09000  ? 69  ILE A CD1    1 
ATOM   1012 H H      . ILE A 1 69  ? 28.56700 -14.13800 -1.73700  1.000 40.17000  ? 69  ILE A H      1 
ATOM   1013 H HA     . ILE A 1 69  ? 27.58200 -12.56200 0.24300   1.000 46.19000  ? 69  ILE A HA     1 
ATOM   1014 H HB     . ILE A 1 69  ? 27.64300 -15.40400 0.22500   1.000 38.76000  ? 69  ILE A HB     1 
ATOM   1015 H HG12   . ILE A 1 69  ? 25.34100 -13.81100 -0.16800  1.000 44.74000  ? 69  ILE A HG12   1 
ATOM   1016 H HG13   . ILE A 1 69  ? 26.12100 -14.49400 -1.37200  1.000 44.74000  ? 69  ILE A HG13   1 
ATOM   1017 H HG21   . ILE A 1 69  ? 26.31600 -15.31600 2.10500   1.000 51.17000  ? 69  ILE A HG21   1 
ATOM   1018 H HG22   . ILE A 1 69  ? 27.73600 -14.65300 2.36100   1.000 51.17000  ? 69  ILE A HG22   1 
ATOM   1019 H HG23   . ILE A 1 69  ? 26.46200 -13.73500 2.12300   1.000 51.17000  ? 69  ILE A HG23   1 
ATOM   1020 H HD11   . ILE A 1 69  ? 24.19700 -15.72800 -0.68500  1.000 52.09000  ? 69  ILE A HD11   1 
ATOM   1021 H HD12   . ILE A 1 69  ? 25.53000 -16.59100 -0.64400  1.000 52.09000  ? 69  ILE A HD12   1 
ATOM   1022 H HD13   . ILE A 1 69  ? 24.92400 -16.00100 0.70000   1.000 52.09000  ? 69  ILE A HD13   1 
ATOM   1023 N N      . ILE A 1 70  ? 29.64900 -12.45000 1.52800   1.000 29.10000  ? 70  ILE A N      1 
ATOM   1024 C CA     . ILE A 1 70  ? 30.99000 -12.26600 2.11400   1.000 29.54000  ? 70  ILE A CA     1 
ATOM   1025 C C      . ILE A 1 70  ? 30.93300 -12.18600 3.63000   1.000 29.59000  ? 70  ILE A C      1 
ATOM   1026 O O      . ILE A 1 70  ? 30.75500 -11.08700 4.17200   1.000 30.82000  ? 70  ILE A O      1 
ATOM   1027 C CB     . ILE A 1 70  ? 31.64900 -10.98400 1.58900   1.000 36.88000  ? 70  ILE A CB     1 
ATOM   1028 C CG1    . ILE A 1 70  ? 31.56800 -10.94400 0.04500   1.000 36.25000  ? 70  ILE A CG1    1 
ATOM   1029 C CG2    . ILE A 1 70  ? 33.13200 -10.91600 2.05700   1.000 33.84000  ? 70  ILE A CG2    1 
ATOM   1030 C CD1    . ILE A 1 70  ? 30.72300 -9.83300  -0.45200  1.000 44.70000  ? 70  ILE A CD1    1 
ATOM   1031 H H      . ILE A 1 70  ? 29.06900 -11.87400 1.79600   1.000 35.30000  ? 70  ILE A H      1 
ATOM   1032 H HA     . ILE A 1 70  ? 31.50400 -13.05100 1.86900   1.000 35.83000  ? 70  ILE A HA     1 
ATOM   1033 H HB     . ILE A 1 70  ? 31.17500 -10.21700 1.94600   1.000 44.64000  ? 70  ILE A HB     1 
ATOM   1034 H HG12   . ILE A 1 70  ? 32.46000 -10.82800 -0.31600  1.000 43.88000  ? 70  ILE A HG12   1 
ATOM   1035 H HG13   . ILE A 1 70  ? 31.18600 -11.77700 -0.27300  1.000 43.88000  ? 70  ILE A HG13   1 
ATOM   1036 H HG21   . ILE A 1 70  ? 33.53700 -10.10800 1.70700   1.000 40.99000  ? 70  ILE A HG21   1 
ATOM   1037 H HG22   . ILE A 1 70  ? 33.15700 -10.90600 3.02600   1.000 40.99000  ? 70  ILE A HG22   1 
ATOM   1038 H HG23   . ILE A 1 70  ? 33.60400 -11.69500 1.72200   1.000 40.99000  ? 70  ILE A HG23   1 
ATOM   1039 H HD11   . ILE A 1 70  ? 30.66000 -9.89200  -1.41800  1.000 54.03000  ? 70  ILE A HD11   1 
ATOM   1040 H HD12   . ILE A 1 70  ? 29.84000 -9.90600  -0.05700  1.000 54.03000  ? 70  ILE A HD12   1 
ATOM   1041 H HD13   . ILE A 1 70  ? 31.12900 -8.98900  -0.19800  1.000 54.03000  ? 70  ILE A HD13   1 
ATOM   1042 N N      . PRO A 1 71  ? 31.00500 -13.33800 4.31900   1.000 31.29000  ? 71  PRO A N      1 
ATOM   1043 C CA     . PRO A 1 71  ? 31.07700 -13.34700 5.78900   1.000 38.81000  ? 71  PRO A CA     1 
ATOM   1044 C C      . PRO A 1 71  ? 32.34000 -12.62000 6.22300   1.000 34.03000  ? 71  PRO A C      1 
ATOM   1045 O O      . PRO A 1 71  ? 33.41000 -12.90100 5.65000   1.000 41.22000  ? 71  PRO A O      1 
ATOM   1046 C CB     . PRO A 1 71  ? 31.00400 -14.82800 6.13400   1.000 32.44000  ? 71  PRO A CB     1 
ATOM   1047 C CG     . PRO A 1 71  ? 31.46000 -15.54900 4.89100   1.000 35.13000  ? 71  PRO A CG     1 
ATOM   1048 C CD     . PRO A 1 71  ? 30.90700 -14.73700 3.79000   1.000 38.78000  ? 71  PRO A CD     1 
ATOM   1049 H HA     . PRO A 1 71  ? 30.29200 -12.88800 6.15600   1.000 46.96000  ? 71  PRO A HA     1 
ATOM   1050 H HB2    . PRO A 1 71  ? 31.58700 -15.03600 6.89000   1.000 39.31000  ? 71  PRO A HB2    1 
ATOM   1051 H HB3    . PRO A 1 71  ? 30.09000 -15.08400 6.36700   1.000 39.31000  ? 71  PRO A HB3    1 
ATOM   1052 H HG2    . PRO A 1 71  ? 32.43600 -15.58100 4.84200   1.000 42.54000  ? 71  PRO A HG2    1 
ATOM   1053 H HG3    . PRO A 1 71  ? 31.10700 -16.46000 4.86200   1.000 42.54000  ? 71  PRO A HG3    1 
ATOM   1054 H HD2    . PRO A 1 71  ? 31.43400 -14.84300 2.97600   1.000 46.91000  ? 71  PRO A HD2    1 
ATOM   1055 H HD3    . PRO A 1 71  ? 29.97600 -14.97300 3.60500   1.000 46.91000  ? 71  PRO A HD3    1 
ATOM   1056 N N      . GLN A 1 72  ? 32.21600 -11.70000 7.16900   1.000 29.52000  ? 72  GLN A N      1 
ATOM   1057 C CA     . GLN A 1 72  ? 33.34500 -10.92300 7.72900   1.000 39.52000  ? 72  GLN A CA     1 
ATOM   1058 C C      . GLN A 1 72  ? 33.37100 -11.23300 9.22700   1.000 38.31000  ? 72  GLN A C      1 
ATOM   1059 O O      . GLN A 1 72  ? 32.84900 -10.44800 9.99200   1.000 36.82000  ? 72  GLN A O      1 
ATOM   1060 C CB     . GLN A 1 72  ? 33.13400 -9.44600  7.41500   1.000 44.10000  ? 72  GLN A CB     1 
ATOM   1061 C CG     . GLN A 1 72  ? 32.84400 -9.15700  5.95000   1.000 45.09000  ? 72  GLN A CG     1 
ATOM   1062 C CD     . GLN A 1 72  ? 33.63800 -7.98300  5.43200   1.000 44.94000  ? 72  GLN A CD     1 
ATOM   1063 O OE1    . GLN A 1 72  ? 33.47300 -6.84500  5.88000   1.000 43.36000  ? 72  GLN A OE1    1 
ATOM   1064 N NE2    . GLN A 1 72  ? 34.51900 -8.26000  4.48400   1.000 42.68000  ? 72  GLN A NE2    1 
ATOM   1065 H H      . GLN A 1 72  ? 31.41800 -11.53900 7.54900   1.000 35.81000  ? 72  GLN A H      1 
ATOM   1066 H HA     . GLN A 1 72  ? 34.19000 -11.23200 7.32200   1.000 47.80000  ? 72  GLN A HA     1 
ATOM   1067 H HB2    . GLN A 1 72  ? 32.38600 -9.11000  7.95000   1.000 53.31000  ? 72  GLN A HB2    1 
ATOM   1068 H HB3    . GLN A 1 72  ? 33.93600 -8.95200  7.68400   1.000 53.31000  ? 72  GLN A HB3    1 
ATOM   1069 H HG2    . GLN A 1 72  ? 33.06200 -9.94500  5.41000   1.000 54.49000  ? 72  GLN A HG2    1 
ATOM   1070 H HG3    . GLN A 1 72  ? 31.88600 -8.97000  5.83700   1.000 54.49000  ? 72  GLN A HG3    1 
ATOM   1071 H HE21   . GLN A 1 72  ? 35.24500 -7.76000  4.39500   1.000 51.60000  ? 72  GLN A HE21   1 
ATOM   1072 H HE22   . GLN A 1 72  ? 34.37700 -8.94500  3.93900   1.000 51.60000  ? 72  GLN A HE22   1 
ATOM   1073 N N      . LYS A 1 73  ? 33.93300 -12.36700 9.62000   1.000 42.40000  ? 73  LYS A N      1 
ATOM   1074 C CA     . LYS A 1 73  ? 33.87900 -12.80700 11.03600  1.000 44.07000  ? 73  LYS A CA     1 
ATOM   1075 C C      . LYS A 1 73  ? 34.60000 -11.81000 11.95100  1.000 38.33000  ? 73  LYS A C      1 
ATOM   1076 O O      . LYS A 1 73  ? 34.15400 -11.67200 13.09500  1.000 44.47000  ? 73  LYS A O      1 
ATOM   1077 C CB     . LYS A 1 73  ? 34.43600 -14.22800 11.13000  1.000 44.85000  ? 73  LYS A CB     1 
ATOM   1078 C CG     . LYS A 1 73  ? 33.38200 -15.29900 10.95200  1.000 63.74000  ? 73  LYS A CG     1 
ATOM   1079 C CD     . LYS A 1 73  ? 33.50300 -16.07100 9.64700   1.000 69.79000  ? 73  LYS A CD     1 
ATOM   1080 C CE     . LYS A 1 73  ? 33.42000 -17.54100 9.87200   1.000 68.97000  ? 73  LYS A CE     1 
ATOM   1081 N NZ     . LYS A 1 73  ? 34.61300 -18.03800 10.55800  1.000 85.60000  ? 73  LYS A NZ     1 
ATOM   1082 H H      . LYS A 1 73  ? 34.35900 -12.91000 9.04000   1.000 51.26000  ? 73  LYS A H      1 
ATOM   1083 H HA     . LYS A 1 73  ? 32.92700 -12.83600 11.30800  1.000 53.26000  ? 73  LYS A HA     1 
ATOM   1084 H HB2    . LYS A 1 73  ? 35.12600 -14.34600 10.44400  1.000 54.20000  ? 73  LYS A HB2    1 
ATOM   1085 H HB3    . LYS A 1 73  ? 34.85900 -14.34600 12.00600  1.000 54.20000  ? 73  LYS A HB3    1 
ATOM   1086 H HG2    . LYS A 1 73  ? 33.44100 -15.92600 11.70300  1.000 76.87000  ? 73  LYS A HG2    1 
ATOM   1087 H HG3    . LYS A 1 73  ? 32.49900 -14.87500 10.98500  1.000 76.87000  ? 73  LYS A HG3    1 
ATOM   1088 H HD2    . LYS A 1 73  ? 32.78000 -15.79500 9.04200   1.000 84.13000  ? 73  LYS A HD2    1 
ATOM   1089 H HD3    . LYS A 1 73  ? 34.35900 -15.85900 9.22100   1.000 84.13000  ? 73  LYS A HD3    1 
ATOM   1090 H HE2    . LYS A 1 73  ? 32.63300 -17.74100 10.41000  1.000 83.14000  ? 73  LYS A HE2    1 
ATOM   1091 H HE3    . LYS A 1 73  ? 33.33000 -17.99600 9.01600   1.000 83.14000  ? 73  LYS A HE3    1 
ATOM   1092 H HZ1    . LYS A 1 73  ? 34.79100 -18.88500 10.29300  1.000 103.10000 ? 73  LYS A HZ1    1 
ATOM   1093 H HZ2    . LYS A 1 73  ? 35.31900 -17.50700 10.35900  1.000 103.10000 ? 73  LYS A HZ2    1 
ATOM   1094 H HZ3    . LYS A 1 73  ? 34.47900 -18.02700 11.45400  1.000 103.10000 ? 73  LYS A HZ3    1 
ATOM   1095 N N      . ASP A 1 74  ? 35.65100 -11.13400 11.48600  1.000 49.46000  ? 74  ASP A N      1 
ATOM   1096 C CA     . ASP A 1 74  ? 36.30000 -10.11000 12.31400  1.000 51.06000  ? 74  ASP A CA     1 
ATOM   1097 C C      . ASP A 1 74  ? 35.28900 -9.10200  12.85500  1.000 54.14000  ? 74  ASP A C      1 
ATOM   1098 O O      . ASP A 1 74  ? 35.34800 -8.70500  14.01500  1.000 46.12000  ? 74  ASP A O      1 
ATOM   1099 C CB     . ASP A 1 74  ? 37.39400 -9.35100  11.52100  1.000 46.67000  ? 74  ASP A CB     1 
ATOM   1100 C CG     . ASP A 1 74  ? 38.67600 -10.20100 11.29000  1.000 84.90000  ? 74  ASP A CG     1 
ATOM   1101 O OD1    . ASP A 1 74  ? 38.86800 -11.28300 11.93100  1.000 71.88000  ? 74  ASP A OD1    1 
ATOM   1102 O OD2    . ASP A 1 74  ? 39.52700 -9.77200  10.45200  1.000 75.51000  ? 74  ASP A OD2    1 
ATOM   1103 H H      . ASP A 1 74  ? 36.02200 -11.26300 10.72100  1.000 59.73000  ? 74  ASP A H      1 
ATOM   1104 H HA     . ASP A 1 74  ? 36.72600 -10.56800 13.05500  1.000 61.65000  ? 74  ASP A HA     1 
ATOM   1105 H HB2    . ASP A 1 74  ? 37.04000 -9.10200  10.65300  1.000 56.38000  ? 74  ASP A HB2    1 
ATOM   1106 H HB3    . ASP A 1 74  ? 37.64800 -8.55600  12.01600  1.000 56.38000  ? 74  ASP A HB3    1 
ATOM   1107 N N      . GLN A 1 75  ? 34.41700 -8.58300  11.99300  1.000 43.37000  ? 75  GLN A N      1 
ATOM   1108 C CA     . GLN A 1 75  ? 33.52200 -7.46500  12.36000  1.000 43.58000  ? 75  GLN A CA     1 
ATOM   1109 C C      . GLN A 1 75  ? 32.11400 -7.93300  12.69900  1.000 38.25000  ? 75  GLN A C      1 
ATOM   1110 O O      . GLN A 1 75  ? 31.29100 -7.05800  12.96000  1.000 40.16000  ? 75  GLN A O      1 
ATOM   1111 C CB     . GLN A 1 75  ? 33.51000 -6.53200  11.15600  1.000 49.37000  ? 75  GLN A CB     1 
ATOM   1112 C CG     . GLN A 1 75  ? 34.87400 -5.98900  10.76000  1.000 57.30000  ? 75  GLN A CG     1 
ATOM   1113 C CD     . GLN A 1 75  ? 35.16400 -6.18400  9.29100   1.000 76.46000  ? 75  GLN A CD     1 
ATOM   1114 O OE1    . GLN A 1 75  ? 34.90000 -5.31000  8.46100   1.000 64.43000  ? 75  GLN A OE1    1 
ATOM   1115 N NE2    . GLN A 1 75  ? 35.69900 -7.34700  8.95600   1.000 75.98000  ? 75  GLN A NE2    1 
ATOM   1116 H H      . GLN A 1 75  ? 34.32100 -8.89700  11.15200  1.000 52.42000  ? 75  GLN A H      1 
ATOM   1117 H HA     . GLN A 1 75  ? 33.89800 -6.97700  13.13100  1.000 52.68000  ? 75  GLN A HA     1 
ATOM   1118 H HB2    . GLN A 1 75  ? 33.13100 -7.02000  10.39400  1.000 59.62000  ? 75  GLN A HB2    1 
ATOM   1119 H HB3    . GLN A 1 75  ? 32.91500 -5.77900  11.34800  1.000 59.62000  ? 75  GLN A HB3    1 
ATOM   1120 H HG2    . GLN A 1 75  ? 34.91300 -5.03200  10.96500  1.000 69.14000  ? 75  GLN A HG2    1 
ATOM   1121 H HG3    . GLN A 1 75  ? 35.57200 -6.43500  11.28300  1.000 69.14000  ? 75  GLN A HG3    1 
ATOM   1122 H HE21   . GLN A 1 75  ? 35.44700 -8.08600  9.38100   1.000 91.56000  ? 75  GLN A HE21   1 
ATOM   1123 H HE22   . GLN A 1 75  ? 36.30100 -7.39000  8.30800   1.000 91.56000  ? 75  GLN A HE22   1 
ATOM   1124 N N      . LYS A 1 76  ? 31.84600 -9.23600  12.71100  1.000 45.24000  ? 76  LYS A N      1 
ATOM   1125 C CA     . LYS A 1 76  ? 30.48400 -9.73800  12.91100  1.000 45.40000  ? 76  LYS A CA     1 
ATOM   1126 C C      . LYS A 1 76  ? 29.53200 -9.15700  11.85400  1.000 48.27000  ? 76  LYS A C      1 
ATOM   1127 O O      . LYS A 1 76  ? 28.40600 -8.74900  12.13000  1.000 52.32000  ? 76  LYS A O      1 
ATOM   1128 C CB     . LYS A 1 76  ? 30.02100 -9.45500  14.34200  1.000 56.78000  ? 76  LYS A CB     1 
ATOM   1129 C CG     . LYS A 1 76  ? 30.33300 -10.63100 15.30000  1.000 66.79000  ? 76  LYS A CG     1 
ATOM   1130 C CD     . LYS A 1 76  ? 30.93900 -10.22600 16.63800  1.000 91.49000  ? 76  LYS A CD     1 
ATOM   1131 C CE     . LYS A 1 76  ? 29.87600 -9.99600  17.70200  1.000 95.62000  ? 76  LYS A CE     1 
ATOM   1132 N NZ     . LYS A 1 76  ? 30.31400 -10.45300 19.06900  1.000 100.88000 ? 76  LYS A NZ     1 
ATOM   1133 H H      . LYS A 1 76  ? 32.42900 -9.85500  12.58100  1.000 54.67000  ? 76  LYS A H      1 
ATOM   1134 H HA     . LYS A 1 76  ? 30.46800 -10.70100 12.79100  1.000 54.86000  ? 76  LYS A HA     1 
ATOM   1135 H HB2    . LYS A 1 76  ? 30.47700 -8.66500  14.67300  1.000 68.51000  ? 76  LYS A HB2    1 
ATOM   1136 H HB3    . LYS A 1 76  ? 29.06200 -9.30900  14.34300  1.000 68.51000  ? 76  LYS A HB3    1 
ATOM   1137 H HG2    . LYS A 1 76  ? 29.50600 -11.10300 15.48700  1.000 80.53000  ? 76  LYS A HG2    1 
ATOM   1138 H HG3    . LYS A 1 76  ? 30.96300 -11.22500 14.86400  1.000 80.53000  ? 76  LYS A HG3    1 
ATOM   1139 H HD2    . LYS A 1 76  ? 31.52900 -10.93100 16.94800  1.000 110.17000 ? 76  LYS A HD2    1 
ATOM   1140 H HD3    . LYS A 1 76  ? 31.43700 -9.40100  16.52600  1.000 110.17000 ? 76  LYS A HD3    1 
ATOM   1141 H HE2    . LYS A 1 76  ? 29.67700 -9.04800  17.75100  1.000 115.12000 ? 76  LYS A HE2    1 
ATOM   1142 H HE3    . LYS A 1 76  ? 29.07700 -10.49100 17.46200  1.000 115.12000 ? 76  LYS A HE3    1 
ATOM   1143 H HZ1    . LYS A 1 76  ? 29.66600 -10.30500 19.66200  1.000 121.44000 ? 76  LYS A HZ1    1 
ATOM   1144 H HZ2    . LYS A 1 76  ? 30.49900 -11.32300 19.05500  1.000 121.44000 ? 76  LYS A HZ2    1 
ATOM   1145 H HZ3    . LYS A 1 76  ? 31.04200 -10.00700 19.32000  1.000 121.44000 ? 76  LYS A HZ3    1 
ATOM   1146 N N      . VAL A 1 77  ? 29.98800 -9.17700  10.61100  1.000 40.66000  ? 77  VAL A N      1 
ATOM   1147 C CA     . VAL A 1 77  ? 29.27400 -8.60800  9.49000   1.000 43.35000  ? 77  VAL A CA     1 
ATOM   1148 C C      . VAL A 1 77  ? 29.11000 -9.67100  8.40800   1.000 36.65000  ? 77  VAL A C      1 
ATOM   1149 O O      . VAL A 1 77  ? 30.04200 -10.42700 8.09900   1.000 32.29000  ? 77  VAL A O      1 
ATOM   1150 C CB     . VAL A 1 77  ? 30.03500 -7.38300  8.95400   1.000 45.78000  ? 77  VAL A CB     1 
ATOM   1151 C CG1    . VAL A 1 77  ? 29.55400 -7.06300  7.53400   1.000 44.01000  ? 77  VAL A CG1    1 
ATOM   1152 C CG2    . VAL A 1 77  ? 29.89400 -6.19300  9.87900   1.000 44.32000  ? 77  VAL A CG2    1 
ATOM   1153 H H      . VAL A 1 77  ? 30.73900 -9.52900  10.38700  1.000 49.18000  ? 77  VAL A H      1 
ATOM   1154 H HA     . VAL A 1 77  ? 28.38200 -8.33900  9.76200   1.000 52.40000  ? 77  VAL A HA     1 
ATOM   1155 H HB     . VAL A 1 77  ? 30.98300 -7.58500  8.91600   1.000 55.32000  ? 77  VAL A HB     1 
ATOM   1156 H HG11   . VAL A 1 77  ? 29.86600 -6.17900  7.28600   1.000 53.20000  ? 77  VAL A HG11   1 
ATOM   1157 H HG12   . VAL A 1 77  ? 29.91300 -7.72500  6.92200   1.000 53.20000  ? 77  VAL A HG12   1 
ATOM   1158 H HG13   . VAL A 1 77  ? 28.58400 -7.08900  7.51600   1.000 53.20000  ? 77  VAL A HG13   1 
ATOM   1159 H HG21   . VAL A 1 77  ? 30.41200 -5.45400  9.52500   1.000 53.56000  ? 77  VAL A HG21   1 
ATOM   1160 H HG22   . VAL A 1 77  ? 28.95800 -5.94400  9.93400   1.000 53.56000  ? 77  VAL A HG22   1 
ATOM   1161 H HG23   . VAL A 1 77  ? 30.22300 -6.43600  10.75900  1.000 53.56000  ? 77  VAL A HG23   1 
ATOM   1162 N N      . LEU A 1 78  ? 27.90700 -9.74700  7.85300   1.000 36.42000  ? 78  LEU A N      1 
ATOM   1163 C CA     . LEU A 1 78  ? 27.63800 -10.51800 6.64700   1.000 29.79000  ? 78  LEU A CA     1 
ATOM   1164 C C      . LEU A 1 78  ? 27.33500 -9.50500  5.54600   1.000 35.74000  ? 78  LEU A C      1 
ATOM   1165 O O      . LEU A 1 78  ? 26.43400 -8.66000  5.71100   1.000 33.61000  ? 78  LEU A O      1 
ATOM   1166 C CB     . LEU A 1 78  ? 26.47400 -11.47100 6.87800   1.000 34.35000  ? 78  LEU A CB     1 
ATOM   1167 C CG     . LEU A 1 78  ? 26.08100 -12.29100 5.66900   1.000 36.10000  ? 78  LEU A CG     1 
ATOM   1168 C CD1    . LEU A 1 78  ? 27.01900 -13.38800 5.29200   1.000 31.93000  ? 78  LEU A CD1    1 
ATOM   1169 C CD2    . LEU A 1 78  ? 24.71500 -12.93100 5.91900   1.000 34.40000  ? 78  LEU A CD2    1 
ATOM   1170 H H      . LEU A 1 78  ? 27.21200 -9.34800  8.16500   1.000 44.08000  ? 78  LEU A H      1 
ATOM   1171 H HA     . LEU A 1 78  ? 28.40100 -11.05500 6.38100   1.000 36.13000  ? 78  LEU A HA     1 
ATOM   1172 H HB2    . LEU A 1 78  ? 26.71800 -12.08900 7.58500   1.000 41.60000  ? 78  LEU A HB2    1 
ATOM   1173 H HB3    . LEU A 1 78  ? 25.69900 -10.95200 7.14400   1.000 41.60000  ? 78  LEU A HB3    1 
ATOM   1174 H HG     . LEU A 1 78  ? 26.08400 -11.66600 4.92800   1.000 43.70000  ? 78  LEU A HG     1 
ATOM   1175 H HD11   . LEU A 1 78  ? 26.69100 -13.82100 4.48900   1.000 38.69000  ? 78  LEU A HD11   1 
ATOM   1176 H HD12   . LEU A 1 78  ? 27.89700 -13.01000 5.12900   1.000 38.69000  ? 78  LEU A HD12   1 
ATOM   1177 H HD13   . LEU A 1 78  ? 27.06500 -14.02900 6.01900   1.000 38.69000  ? 78  LEU A HD13   1 
ATOM   1178 H HD21   . LEU A 1 78  ? 24.45000 -13.42900 5.13100   1.000 41.67000  ? 78  LEU A HD21   1 
ATOM   1179 H HD22   . LEU A 1 78  ? 24.78000 -13.52700 6.68200   1.000 41.67000  ? 78  LEU A HD22   1 
ATOM   1180 H HD23   . LEU A 1 78  ? 24.06800 -12.23100 6.10100   1.000 41.67000  ? 78  LEU A HD23   1 
ATOM   1181 N N      . GLU A 1 79  ? 28.08200 -9.58900  4.44100   1.000 31.70000  ? 79  GLU A N      1 
ATOM   1182 C CA     . GLU A 1 79  ? 27.89900 -8.71500  3.29800   1.000 31.06000  ? 79  GLU A CA     1 
ATOM   1183 C C      . GLU A 1 79  ? 27.25300 -9.49300  2.15800   1.000 42.83000  ? 79  GLU A C      1 
ATOM   1184 O O      . GLU A 1 79  ? 27.61000 -10.64900 1.86400   1.000 30.14000  ? 79  GLU A O      1 
ATOM   1185 C CB     . GLU A 1 79  ? 29.22700 -8.10700  2.81500   1.000 29.95000  ? 79  GLU A CB     1 
ATOM   1186 C CG     . GLU A 1 79  ? 29.89300 -7.15800  3.80400   1.000 30.97000  ? 79  GLU A CG     1 
ATOM   1187 C CD     . GLU A 1 79  ? 31.25900 -6.68600  3.34300   1.000 33.35000  ? 79  GLU A CD     1 
ATOM   1188 O OE1    . GLU A 1 79  ? 32.04200 -7.47300  2.68800   1.000 31.65000  ? 79  GLU A OE1    1 
ATOM   1189 O OE2    . GLU A 1 79  ? 31.57500 -5.50900  3.66700   1.000 36.13000  ? 79  GLU A OE2    1 
ATOM   1190 H H      . GLU A 1 79  ? 28.71500 -10.16000 4.33500   1.000 38.43000  ? 79  GLU A H      1 
ATOM   1191 H HA     . GLU A 1 79  ? 27.31900 -7.98200  3.55700   1.000 37.65000  ? 79  GLU A HA     1 
ATOM   1192 H HB2    . GLU A 1 79  ? 29.85000 -8.83000  2.63900   1.000 36.32000  ? 79  GLU A HB2    1 
ATOM   1193 H HB3    . GLU A 1 79  ? 29.05900 -7.60900  2.00000   1.000 36.32000  ? 79  GLU A HB3    1 
ATOM   1194 H HG2    . GLU A 1 79  ? 29.33000 -6.37700  3.91900   1.000 37.55000  ? 79  GLU A HG2    1 
ATOM   1195 H HG3    . GLU A 1 79  ? 30.00500 -7.61500  4.65200   1.000 37.55000  ? 79  GLU A HG3    1 
ATOM   1196 N N      . ILE A 1 80  ? 26.30500 -8.84000  1.50800   1.000 26.83000  ? 80  ILE A N      1 
ATOM   1197 C CA     . ILE A 1 80  ? 25.62600 -9.37900  0.33700   1.000 27.89000  ? 80  ILE A CA     1 
ATOM   1198 C C      . ILE A 1 80  ? 25.71300 -8.38200  -0.78800  1.000 27.41000  ? 80  ILE A C      1 
ATOM   1199 O O      . ILE A 1 80  ? 25.07400 -7.32500  -0.72600  1.000 32.58000  ? 80  ILE A O      1 
ATOM   1200 C CB     . ILE A 1 80  ? 24.14400 -9.70000  0.58300   1.000 32.74000  ? 80  ILE A CB     1 
ATOM   1201 C CG1    . ILE A 1 80  ? 24.00400 -10.72900 1.66600   1.000 40.14000  ? 80  ILE A CG1    1 
ATOM   1202 C CG2    . ILE A 1 80  ? 23.54000 -10.22700 -0.71300  1.000 25.44000  ? 80  ILE A CG2    1 
ATOM   1203 C CD1    . ILE A 1 80  ? 22.97400 -10.37500 2.57800   1.000 44.61000  ? 80  ILE A CD1    1 
ATOM   1204 H H      . ILE A 1 80  ? 26.02700 -8.05700  1.73200   1.000 32.57000  ? 80  ILE A H      1 
ATOM   1205 H HA     . ILE A 1 80  ? 26.10300 -10.18700 0.09100   1.000 33.85000  ? 80  ILE A HA     1 
ATOM   1206 H HB     . ILE A 1 80  ? 23.68300 -8.89500  0.86500   1.000 39.67000  ? 80  ILE A HB     1 
ATOM   1207 H HG12   . ILE A 1 80  ? 23.78300 -11.58600 1.27000   1.000 48.55000  ? 80  ILE A HG12   1 
ATOM   1208 H HG13   . ILE A 1 80  ? 24.83900 -10.79600 2.15600   1.000 48.55000  ? 80  ILE A HG13   1 
ATOM   1209 H HG21   . ILE A 1 80  ? 22.67000 -10.61100 -0.52200  1.000 30.91000  ? 80  ILE A HG21   1 
ATOM   1210 H HG22   . ILE A 1 80  ? 23.44700 -9.49200  -1.33900  1.000 30.91000  ? 80  ILE A HG22   1 
ATOM   1211 H HG23   . ILE A 1 80  ? 24.12700 -10.90500 -1.08300  1.000 30.91000  ? 80  ILE A HG23   1 
ATOM   1212 H HD11   . ILE A 1 80  ? 23.00300 -10.97900 3.33700   1.000 53.92000  ? 80  ILE A HD11   1 
ATOM   1213 H HD12   . ILE A 1 80  ? 23.11500 -9.46300  2.87600   1.000 53.92000  ? 80  ILE A HD12   1 
ATOM   1214 H HD13   . ILE A 1 80  ? 22.11700 -10.44800 2.13000   1.000 53.92000  ? 80  ILE A HD13   1 
ATOM   1215 N N      . ARG A 1 81  ? 26.46200 -8.72600  -1.82200  1.000 25.69000  ? 81  ARG A N      1 
ATOM   1216 C CA     . ARG A 1 81  ? 26.80600 -7.85100  -2.92800  1.000 36.55000  ? 81  ARG A CA     1 
ATOM   1217 C C      . ARG A 1 81  ? 26.28000 -8.40800  -4.23400  1.000 35.75000  ? 81  ARG A C      1 
ATOM   1218 O O      . ARG A 1 81  ? 26.41400 -9.60600  -4.51200  1.000 30.89000  ? 81  ARG A O      1 
ATOM   1219 C CB     . ARG A 1 81  ? 28.33700 -7.70000  -3.01100  1.000 34.72000  ? 81  ARG A CB     1 
ATOM   1220 C CG     . ARG A 1 81  ? 28.82200 -6.96200  -4.23800  1.000 31.74000  ? 81  ARG A CG     1 
ATOM   1221 C CD     . ARG A 1 81  ? 30.38800 -6.81900  -4.26000  1.000 42.06000  ? 81  ARG A CD     1 
ATOM   1222 N NE     . ARG A 1 81  ? 30.83000 -6.14400  -5.48200  1.000 43.30000  ? 81  ARG A NE     1 
ATOM   1223 C CZ     . ARG A 1 81  ? 32.08300 -6.03200  -5.91900  1.000 41.74000  ? 81  ARG A CZ     1 
ATOM   1224 N NH1    . ARG A 1 81  ? 33.10300 -6.53700  -5.23900  1.000 44.78000  ? 81  ARG A NH1    1 
ATOM   1225 N NH2    . ARG A 1 81  ? 32.31300 -5.40000  -7.07900  1.000 41.80000  ? 81  ARG A NH2    1 
ATOM   1226 H H      . ARG A 1 81  ? 26.80300 -9.51100  -1.91100  1.000 31.21000  ? 81  ARG A H      1 
ATOM   1227 H HA     . ARG A 1 81  ? 26.39600 -6.98200  -2.79900  1.000 44.24000  ? 81  ARG A HA     1 
ATOM   1228 H HB2    . ARG A 1 81  ? 28.64300 -7.20800  -2.23300  1.000 42.04000  ? 81  ARG A HB2    1 
ATOM   1229 H HB3    . ARG A 1 81  ? 28.73600 -8.58400  -3.02300  1.000 42.04000  ? 81  ARG A HB3    1 
ATOM   1230 H HG2    . ARG A 1 81  ? 28.55100 -7.45000  -5.03200  1.000 38.47000  ? 81  ARG A HG2    1 
ATOM   1231 H HG3    . ARG A 1 81  ? 28.43600 -6.07200  -4.24900  1.000 38.47000  ? 81  ARG A HG3    1 
ATOM   1232 H HD2    . ARG A 1 81  ? 30.67600 -6.29400  -3.49600  1.000 50.85000  ? 81  ARG A HD2    1 
ATOM   1233 H HD3    . ARG A 1 81  ? 30.79500 -7.69900  -4.22900  1.000 50.85000  ? 81  ARG A HD3    1 
ATOM   1234 H HE     . ARG A 1 81  ? 30.21800 -5.78300  -5.96700  1.000 52.34000  ? 81  ARG A HE     1 
ATOM   1235 H HH11   . ARG A 1 81  ? 32.96400 -6.94800  -4.49700  1.000 54.12000  ? 81  ARG A HH11   1 
ATOM   1236 H HH12   . ARG A 1 81  ? 33.90400 -6.45300  -5.54100  1.000 54.12000  ? 81  ARG A HH12   1 
ATOM   1237 H HH21   . ARG A 1 81  ? 31.65600 -5.07400  -7.52900  1.000 50.54000  ? 81  ARG A HH21   1 
ATOM   1238 H HH22   . ARG A 1 81  ? 33.11700 -5.32100  -7.37300  1.000 50.54000  ? 81  ARG A HH22   1 
ATOM   1239 N N      . ASP A 1 82  ? 25.69500 -7.53900  -5.03600  1.000 34.84000  ? 82  ASP A N      1 
ATOM   1240 C CA     . ASP A 1 82  ? 25.34700 -7.90100  -6.40200  1.000 33.62000  ? 82  ASP A CA     1 
ATOM   1241 C C      . ASP A 1 82  ? 25.99400 -6.92000  -7.34400  1.000 21.20000  ? 82  ASP A C      1 
ATOM   1242 O O      . ASP A 1 82  ? 26.26000 -5.74900  -6.97500  1.000 32.32000  ? 82  ASP A O      1 
ATOM   1243 C CB     . ASP A 1 82  ? 23.82300 -7.87900  -6.66600  1.000 29.14000  ? 82  ASP A CB     1 
ATOM   1244 C CG     . ASP A 1 82  ? 23.21700 -6.53300  -6.47900  1.000 24.38000  ? 82  ASP A CG     1 
ATOM   1245 O OD1    . ASP A 1 82  ? 23.42000 -5.66000  -7.36600  1.000 37.61000  ? 82  ASP A OD1    1 
ATOM   1246 O OD2    . ASP A 1 82  ? 22.50200 -6.33500  -5.45500  1.000 33.47000  ? 82  ASP A OD2    1 
ATOM   1247 H H      . ASP A 1 82  ? 25.48800 -6.73400  -4.81400  1.000 42.19000  ? 82  ASP A H      1 
ATOM   1248 H HA     . ASP A 1 82  ? 25.66600 -8.80200  -6.56700  1.000 40.73000  ? 82  ASP A HA     1 
ATOM   1249 H HB2    . ASP A 1 82  ? 23.65800 -8.15600  -7.58100  1.000 35.36000  ? 82  ASP A HB2    1 
ATOM   1250 H HB3    . ASP A 1 82  ? 23.38800 -8.49000  -6.05100  1.000 35.36000  ? 82  ASP A HB3    1 
ATOM   1251 N N      . SER A 1 83  ? 26.12000 -7.36300  -8.59700  1.000 29.37000  ? 83  SER A N      1 
ATOM   1252 C CA     . SER A 1 83  ? 26.55300 -6.45300  -9.66900  1.000 24.30000  ? 83  SER A CA     1 
ATOM   1253 C C      . SER A 1 83  ? 25.35000 -5.97500  -10.47200 1.000 42.42000  ? 83  SER A C      1 
ATOM   1254 O O      . SER A 1 83  ? 25.39700 -5.95400  -11.69900 1.000 36.47000  ? 83  SER A O      1 
ATOM   1255 C CB     . SER A 1 83  ? 27.59100 -7.11000  -10.57800 1.000 33.43000  ? 83  SER A CB     1 
ATOM   1256 O OG     . SER A 1 83  ? 27.18800 -8.42800  -11.03200 1.000 34.78000  ? 83  SER A OG     1 
ATOM   1257 H H      . SER A 1 83  ? 25.96400 -8.17100  -8.84800  1.000 35.62000  ? 83  SER A H      1 
ATOM   1258 H HA     . SER A 1 83  ? 26.99300 -5.68600  -9.27100  1.000 29.55000  ? 83  SER A HA     1 
ATOM   1259 H HB2    . SER A 1 83  ? 27.72200 -6.54400  -11.35400 1.000 40.50000  ? 83  SER A HB2    1 
ATOM   1260 H HB3    . SER A 1 83  ? 28.42200 -7.19500  -10.08400 1.000 40.50000  ? 83  SER A HB3    1 
ATOM   1261 H HG     . SER A 1 83  ? 27.85700 -8.85100  -11.31400 1.000 42.12000  ? 83  SER A HG     1 
ATOM   1262 N N      . GLY A 1 84  ? 24.25500 -5.61100  -9.79500  1.000 36.72000  ? 84  GLY A N      1 
ATOM   1263 C CA     . GLY A 1 84  ? 23.04800 -5.17700  -10.46400 1.000 39.38000  ? 84  GLY A CA     1 
ATOM   1264 C C      . GLY A 1 84  ? 23.12200 -3.74200  -10.93500 1.000 37.28000  ? 84  GLY A C      1 
ATOM   1265 O O      . GLY A 1 84  ? 24.19100 -3.13200  -11.06200 1.000 34.96000  ? 84  GLY A O      1 
ATOM   1266 H H      . GLY A 1 84  ? 24.19700 -5.61000  -8.93700  1.000 44.45000  ? 84  GLY A H      1 
ATOM   1267 H HA2    . GLY A 1 84  ? 22.89000 -5.74300  -11.23600 1.000 47.63000  ? 84  GLY A HA2    1 
ATOM   1268 H HA3    . GLY A 1 84  ? 22.29800 -5.25800  -9.85400  1.000 47.63000  ? 84  GLY A HA3    1 
ATOM   1269 N N      . ILE A 1 85  ? 21.94100 -3.19000  -11.17300 1.000 34.59000  ? 85  ILE A N      1 
ATOM   1270 C CA     . ILE A 1 85  ? 21.84300 -1.85800  -11.77000 1.000 45.97000  ? 85  ILE A CA     1 
ATOM   1271 C C      . ILE A 1 85  ? 22.34500 -0.79900  -10.79700 1.000 28.72000  ? 85  ILE A C      1 
ATOM   1272 O O      . ILE A 1 85  ? 22.83900 0.26400   -11.19300 1.000 26.40000  ? 85  ILE A O      1 
ATOM   1273 C CB     . ILE A 1 85  ? 20.40300 -1.54900  -12.18200 1.000 39.58000  ? 85  ILE A CB     1 
ATOM   1274 C CG1    . ILE A 1 85  ? 20.31700 -0.12600  -12.74400 1.000 44.09000  ? 85  ILE A CG1    1 
ATOM   1275 C CG2    . ILE A 1 85  ? 19.47700 -1.60600  -10.97500 1.000 31.38000  ? 85  ILE A CG2    1 
ATOM   1276 C CD1    . ILE A 1 85  ? 19.49800 -0.08000  -13.98900 1.000 43.27000  ? 85  ILE A CD1    1 
ATOM   1277 H H      . ILE A 1 85  ? 21.18300 -3.55800  -11.00200 1.000 41.89000  ? 85  ILE A H      1 
ATOM   1278 H HA     . ILE A 1 85  ? 22.39900 -1.85100  -12.56500 1.000 55.54000  ? 85  ILE A HA     1 
ATOM   1279 H HB     . ILE A 1 85  ? 20.14200 -2.20700  -12.84500 1.000 47.88000  ? 85  ILE A HB     1 
ATOM   1280 H HG12   . ILE A 1 85  ? 19.90600 0.45400   -12.08500 1.000 53.29000  ? 85  ILE A HG12   1 
ATOM   1281 H HG13   . ILE A 1 85  ? 21.21000 0.19000   -12.95400 1.000 53.29000  ? 85  ILE A HG13   1 
ATOM   1282 H HG21   . ILE A 1 85  ? 18.57700 -1.38200  -11.25700 1.000 38.03000  ? 85  ILE A HG21   1 
ATOM   1283 H HG22   . ILE A 1 85  ? 19.49500 -2.50300  -10.60500 1.000 38.03000  ? 85  ILE A HG22   1 
ATOM   1284 H HG23   . ILE A 1 85  ? 19.78400 -0.96800  -10.31100 1.000 38.03000  ? 85  ILE A HG23   1 
ATOM   1285 H HD11   . ILE A 1 85  ? 19.43000 0.84000   -14.28800 1.000 52.30000  ? 85  ILE A HD11   1 
ATOM   1286 H HD12   . ILE A 1 85  ? 19.92800 -0.61800  -14.67100 1.000 52.30000  ? 85  ILE A HD12   1 
ATOM   1287 H HD13   . ILE A 1 85  ? 18.61400 -0.43200  -13.79900 1.000 52.30000  ? 85  ILE A HD13   1 
ATOM   1288 N N      . GLY A 1 86  ? 22.24000 -1.07300  -9.52500  1.000 35.70000  ? 86  GLY A N      1 
ATOM   1289 C CA     . GLY A 1 86  ? 22.74400 -0.13000  -8.55800  1.000 36.70000  ? 86  GLY A CA     1 
ATOM   1290 C C      . GLY A 1 86  ? 21.69700 0.93300   -8.36500  1.000 37.67000  ? 86  GLY A C      1 
ATOM   1291 O O      . GLY A 1 86  ? 20.58800 0.87100   -8.90800  1.000 35.95000  ? 86  GLY A O      1 
ATOM   1292 H H      . GLY A 1 86  ? 21.88700 -1.78600  -9.19800  1.000 43.22000  ? 86  GLY A H      1 
ATOM   1293 H HA2    . GLY A 1 86  ? 22.91900 -0.57300  -7.71200  1.000 44.42000  ? 86  GLY A HA2    1 
ATOM   1294 H HA3    . GLY A 1 86  ? 23.56500 0.27600   -8.87700  1.000 44.42000  ? 86  GLY A HA3    1 
ATOM   1295 N N      . MET A 1 87  ? 22.03500 1.89000   -7.51700  1.000 37.78000  ? 87  MET A N      1 
ATOM   1296 C CA     . MET A 1 87  ? 21.09600 2.89100   -7.04500  1.000 34.31000  ? 87  MET A CA     1 
ATOM   1297 C C      . MET A 1 87  ? 21.79400 4.25100   -7.01700  1.000 46.10000  ? 87  MET A C      1 
ATOM   1298 O O      . MET A 1 87  ? 22.96200 4.35200   -6.65700  1.000 44.80000  ? 87  MET A O      1 
ATOM   1299 C CB     . MET A 1 87  ? 20.54400 2.51800   -5.66600  1.000 36.56000  ? 87  MET A CB     1 
ATOM   1300 C CG     . MET A 1 87  ? 19.54200 1.39900   -5.68900  1.000 47.32000  ? 87  MET A CG     1 
ATOM   1301 S SD     . MET A 1 87  ? 18.76400 1.01400   -4.10900  1.000 41.24000  ? 87  MET A SD     1 
ATOM   1302 C CE     . MET A 1 87  ? 18.10800 2.53400   -3.61900  1.000 34.24000  ? 87  MET A CE     1 
ATOM   1303 H H      . MET A 1 87  ? 22.82500 1.98300   -7.19100  1.000 45.72000  ? 87  MET A H      1 
ATOM   1304 H HA     . MET A 1 87  ? 20.33900 2.95400   -7.64800  1.000 41.56000  ? 87  MET A HA     1 
ATOM   1305 H HB2    . MET A 1 87  ? 21.28200 2.24100   -5.10100  1.000 44.25000  ? 87  MET A HB2    1 
ATOM   1306 H HB3    . MET A 1 87  ? 20.10800 3.29600   -5.28600  1.000 44.25000  ? 87  MET A HB3    1 
ATOM   1307 H HG2    . MET A 1 87  ? 18.83400 1.63700   -6.30800  1.000 57.17000  ? 87  MET A HG2    1 
ATOM   1308 H HG3    . MET A 1 87  ? 19.99100 0.59400   -5.99200  1.000 57.17000  ? 87  MET A HG3    1 
ATOM   1309 H HE1    . MET A 1 87  ? 17.68700 2.43000   -2.75100  1.000 41.48000  ? 87  MET A HE1    1 
ATOM   1310 H HE2    . MET A 1 87  ? 18.82600 3.18400   -3.56200  1.000 41.48000  ? 87  MET A HE2    1 
ATOM   1311 H HE3    . MET A 1 87  ? 17.45200 2.82100   -4.27300  1.000 41.48000  ? 87  MET A HE3    1 
ATOM   1312 N N      . THR A 1 88  ? 21.08100 5.29100   -7.42300  1.000 39.97000  ? 88  THR A N      1 
ATOM   1313 C CA     . THR A 1 88  ? 21.61300 6.63100   -7.32500  1.000 40.24000  ? 88  THR A CA     1 
ATOM   1314 C C      . THR A 1 88  ? 21.46700 7.13300   -5.89800  1.000 47.95000  ? 88  THR A C      1 
ATOM   1315 O O      . THR A 1 88  ? 20.76100 6.54600   -5.06400  1.000 39.74000  ? 88  THR A O      1 
ATOM   1316 C CB     . THR A 1 88  ? 20.87700 7.58800   -8.25600  1.000 38.67000  ? 88  THR A CB     1 
ATOM   1317 O OG1    . THR A 1 88  ? 19.59000 7.79500   -7.68200  1.000 45.19000  ? 88  THR A OG1    1 
ATOM   1318 C CG2    . THR A 1 88  ? 20.75200 7.04800   -9.63700  1.000 40.62000  ? 88  THR A CG2    1 
ATOM   1319 H H      . THR A 1 88  ? 20.29000 5.24400   -7.75800  1.000 48.34000  ? 88  THR A H      1 
ATOM   1320 H HA     . THR A 1 88  ? 22.54800 6.61300   -7.58100  1.000 48.67000  ? 88  THR A HA     1 
ATOM   1321 H HB     . THR A 1 88  ? 21.36400 8.42200   -8.35000  1.000 46.78000  ? 88  THR A HB     1 
ATOM   1322 H HG1    . THR A 1 88  ? 19.08000 8.15900   -8.24200  1.000 54.61000  ? 88  THR A HG1    1 
ATOM   1323 H HG21   . THR A 1 88  ? 20.29600 7.68900   -10.20400 1.000 49.13000  ? 88  THR A HG21   1 
ATOM   1324 H HG22   . THR A 1 88  ? 21.63200 6.87100   -10.00500 1.000 49.13000  ? 88  THR A HG22   1 
ATOM   1325 H HG23   . THR A 1 88  ? 20.24400 6.22200   -9.62500  1.000 49.13000  ? 88  THR A HG23   1 
ATOM   1326 N N      . LYS A 1 89  ? 22.08900 8.28400   -5.63700  1.000 40.39000  ? 89  LYS A N      1 
ATOM   1327 C CA     . LYS A 1 89  ? 21.90800 8.92500   -4.33600  1.000 50.17000  ? 89  LYS A CA     1 
ATOM   1328 C C      . LYS A 1 89  ? 20.43300 9.17900   -4.06100  1.000 41.04000  ? 89  LYS A C      1 
ATOM   1329 O O      . LYS A 1 89  ? 19.92800 8.87200   -2.96500  1.000 50.79000  ? 89  LYS A O      1 
ATOM   1330 C CB     . LYS A 1 89  ? 22.67900 10.23700  -4.26700  1.000 44.79000  ? 89  LYS A CB     1 
ATOM   1331 C CG     . LYS A 1 89  ? 22.79000 10.87200  -2.86200  1.000 43.19000  ? 89  LYS A CG     1 
ATOM   1332 C CD     . LYS A 1 89  ? 23.34800 12.28500  -3.01400  1.000 53.77000  ? 89  LYS A CD     1 
ATOM   1333 C CE     . LYS A 1 89  ? 23.38500 13.08000  -1.72600  1.000 68.28000  ? 89  LYS A CE     1 
ATOM   1334 N NZ     . LYS A 1 89  ? 23.58300 14.54900  -2.00900  1.000 91.84000  ? 89  LYS A NZ     1 
ATOM   1335 H H      . LYS A 1 89  ? 22.60600 8.70300   -6.18100  1.000 48.85000  ? 89  LYS A H      1 
ATOM   1336 H HA     . LYS A 1 89  ? 22.26200 8.33200   -3.65500  1.000 60.59000  ? 89  LYS A HA     1 
ATOM   1337 H HB2    . LYS A 1 89  ? 23.58200 10.07700  -4.58300  1.000 54.13000  ? 89  LYS A HB2    1 
ATOM   1338 H HB3    . LYS A 1 89  ? 22.23600 10.88200  -4.84000  1.000 54.13000  ? 89  LYS A HB3    1 
ATOM   1339 H HG2    . LYS A 1 89  ? 21.91500 10.91900  -2.44800  1.000 52.21000  ? 89  LYS A HG2    1 
ATOM   1340 H HG3    . LYS A 1 89  ? 23.39200 10.35100  -2.30800  1.000 52.21000  ? 89  LYS A HG3    1 
ATOM   1341 H HD2    . LYS A 1 89  ? 24.25600 12.22700  -3.34900  1.000 64.90000  ? 89  LYS A HD2    1 
ATOM   1342 H HD3    . LYS A 1 89  ? 22.79300 12.77300  -3.64300  1.000 64.90000  ? 89  LYS A HD3    1 
ATOM   1343 H HE2    . LYS A 1 89  ? 22.54600 12.96800  -1.25200  1.000 82.32000  ? 89  LYS A HE2    1 
ATOM   1344 H HE3    . LYS A 1 89  ? 24.12200 12.77000  -1.17600  1.000 82.32000  ? 89  LYS A HE3    1 
ATOM   1345 H HZ1    . LYS A 1 89  ? 23.56000 15.01100  -1.24900  1.000 110.59000 ? 89  LYS A HZ1    1 
ATOM   1346 H HZ2    . LYS A 1 89  ? 24.37000 14.68000  -2.40300  1.000 110.59000 ? 89  LYS A HZ2    1 
ATOM   1347 H HZ3    . LYS A 1 89  ? 22.93800 14.84500  -2.54600  1.000 110.59000 ? 89  LYS A HZ3    1 
ATOM   1348 N N      . ALA A 1 90  ? 19.71800 9.74100   -5.04400  1.000 43.37000  ? 90  ALA A N      1 
ATOM   1349 C CA     . ALA A 1 90  ? 18.29100 10.02700  -4.83800  1.000 44.73000  ? 90  ALA A CA     1 
ATOM   1350 C C      . ALA A 1 90  ? 17.48000 8.74200   -4.71000  1.000 39.74000  ? 90  ALA A C      1 
ATOM   1351 O O      . ALA A 1 90  ? 16.53900 8.67800   -3.92800  1.000 38.68000  ? 90  ALA A O      1 
ATOM   1352 C CB     . ALA A 1 90  ? 17.75900 10.86200  -6.00300  1.000 40.01000  ? 90  ALA A CB     1 
ATOM   1353 H H      . ALA A 1 90  ? 20.02400 9.96000   -5.81700  1.000 52.43000  ? 90  ALA A H      1 
ATOM   1354 H HA     . ALA A 1 90  ? 18.19000 10.53500  -4.01700  1.000 54.06000  ? 90  ALA A HA     1 
ATOM   1355 H HB1    . ALA A 1 90  ? 16.83100 11.08700  -5.83200  1.000 48.40000  ? 90  ALA A HB1    1 
ATOM   1356 H HB2    . ALA A 1 90  ? 18.28700 11.67200  -6.07800  1.000 48.40000  ? 90  ALA A HB2    1 
ATOM   1357 H HB3    . ALA A 1 90  ? 17.82900 10.34500  -6.82000  1.000 48.40000  ? 90  ALA A HB3    1 
ATOM   1358 N N      . ASP A 1 91  ? 17.79000 7.73500   -5.52800  1.000 30.15000  ? 91  ASP A N      1 
ATOM   1359 C CA     . ASP A 1 91  ? 17.23500 6.41300   -5.33300  1.000 36.37000  ? 91  ASP A CA     1 
ATOM   1360 C C      . ASP A 1 91  ? 17.34000 5.97000   -3.87000  1.000 46.96000  ? 91  ASP A C      1 
ATOM   1361 O O      . ASP A 1 91  ? 16.37300 5.48200   -3.28400  1.000 52.43000  ? 91  ASP A O      1 
ATOM   1362 C CB     . ASP A 1 91  ? 17.97500 5.40400   -6.21600  1.000 40.25000  ? 91  ASP A CB     1 
ATOM   1363 C CG     . ASP A 1 91  ? 17.61600 5.49500   -7.66100  1.000 41.31000  ? 91  ASP A CG     1 
ATOM   1364 O OD1    . ASP A 1 91  ? 16.48300 5.88600   -8.00700  1.000 56.06000  ? 91  ASP A OD1    1 
ATOM   1365 O OD2    . ASP A 1 91  ? 18.49300 5.11900   -8.46000  1.000 48.33000  ? 91  ASP A OD2    1 
ATOM   1366 H H      . ASP A 1 91  ? 18.32000 7.79900   -6.20200  1.000 36.56000  ? 91  ASP A H      1 
ATOM   1367 H HA     . ASP A 1 91  ? 16.29900 6.43700   -5.58600  1.000 44.03000  ? 91  ASP A HA     1 
ATOM   1368 H HB2    . ASP A 1 91  ? 18.92900 5.56200   -6.13800  1.000 48.68000  ? 91  ASP A HB2    1 
ATOM   1369 H HB3    . ASP A 1 91  ? 17.76100 4.50800   -5.91400  1.000 48.68000  ? 91  ASP A HB3    1 
ATOM   1370 N N      . LEU A 1 92  ? 18.52800 6.07400   -3.27400  1.000 48.66000  ? 92  LEU A N      1 
ATOM   1371 C CA     . LEU A 1 92  ? 18.68200 5.58000   -1.90500  1.000 58.56000  ? 92  LEU A CA     1 
ATOM   1372 C C      . LEU A 1 92  ? 17.76500 6.35000   -0.95900  1.000 50.91000  ? 92  LEU A C      1 
ATOM   1373 O O      . LEU A 1 92  ? 17.13700 5.76700   -0.05500  1.000 55.15000  ? 92  LEU A O      1 
ATOM   1374 C CB     . LEU A 1 92  ? 20.15100 5.66600   -1.44000  1.000 40.49000  ? 92  LEU A CB     1 
ATOM   1375 C CG     . LEU A 1 92  ? 21.01500 4.71000   -2.29200  1.000 41.82000  ? 92  LEU A CG     1 
ATOM   1376 C CD1    . LEU A 1 92  ? 22.48200 5.05300   -2.36400  1.000 40.49000  ? 92  LEU A CD1    1 
ATOM   1377 C CD2    . LEU A 1 92  ? 20.85500 3.33100   -1.68600  1.000 41.71000  ? 92  LEU A CD2    1 
ATOM   1378 H H      . LEU A 1 92  ? 19.23600 6.41400   -3.62700  1.000 58.77000  ? 92  LEU A H      1 
ATOM   1379 H HA     . LEU A 1 92  ? 18.44000 4.64100   -1.88200  1.000 70.65000  ? 92  LEU A HA     1 
ATOM   1380 H HB2    . LEU A 1 92  ? 20.47800 6.57200   -1.55400  1.000 48.97000  ? 92  LEU A HB2    1 
ATOM   1381 H HB3    . LEU A 1 92  ? 20.21700 5.40500   -0.50900  1.000 48.97000  ? 92  LEU A HB3    1 
ATOM   1382 H HG     . LEU A 1 92  ? 20.70900 4.76800   -3.21100  1.000 50.56000  ? 92  LEU A HG     1 
ATOM   1383 H HD11   . LEU A 1 92  ? 22.57800 5.96800   -2.67100  1.000 48.97000  ? 92  LEU A HD11   1 
ATOM   1384 H HD12   . LEU A 1 92  ? 22.87200 4.95700   -1.48100  1.000 48.97000  ? 92  LEU A HD12   1 
ATOM   1385 H HD13   . LEU A 1 92  ? 22.91800 4.44800   -2.98500  1.000 48.97000  ? 92  LEU A HD13   1 
ATOM   1386 H HD21   . LEU A 1 92  ? 21.32800 3.30200   -0.83900  1.000 50.43000  ? 92  LEU A HD21   1 
ATOM   1387 H HD22   . LEU A 1 92  ? 19.91200 3.15500   -1.54400  1.000 50.43000  ? 92  LEU A HD22   1 
ATOM   1388 H HD23   . LEU A 1 92  ? 21.22600 2.67300   -2.29400  1.000 50.43000  ? 92  LEU A HD23   1 
ATOM   1389 N N      . VAL A 1 93  ? 17.67000 7.66400   -1.16200  1.000 61.07000  ? 93  VAL A N      1 
ATOM   1390 C CA     . VAL A 1 93  ? 16.90300 8.47400   -0.24300  1.000 60.03000  ? 93  VAL A CA     1 
ATOM   1391 C C      . VAL A 1 93  ? 15.42100 8.12700   -0.33000  1.000 71.20000  ? 93  VAL A C      1 
ATOM   1392 O O      . VAL A 1 93  ? 14.69600 8.19500   0.66900   1.000 78.03000  ? 93  VAL A O      1 
ATOM   1393 C CB     . VAL A 1 93  ? 17.13900 9.96700   -0.51100  1.000 53.89000  ? 93  VAL A CB     1 
ATOM   1394 C CG1    . VAL A 1 93  ? 16.16600 10.72300  0.33500   1.000 51.84000  ? 93  VAL A CG1    1 
ATOM   1395 C CG2    . VAL A 1 93  ? 18.57000 10.35800  -0.19400  1.000 54.68000  ? 93  VAL A CG2    1 
ATOM   1396 H H      . VAL A 1 93  ? 18.03400 8.09400   -1.81200  1.000 73.67000  ? 93  VAL A H      1 
ATOM   1397 H HA     . VAL A 1 93  ? 17.20900 8.28200   0.65700   1.000 72.42000  ? 93  VAL A HA     1 
ATOM   1398 H HB     . VAL A 1 93  ? 17.00400 10.17900  -1.44700  1.000 65.05000  ? 93  VAL A HB     1 
ATOM   1399 H HG11   . VAL A 1 93  ? 16.42600 11.65700  0.35900   1.000 62.59000  ? 93  VAL A HG11   1 
ATOM   1400 H HG12   . VAL A 1 93  ? 15.27900 10.63600  -0.05000  1.000 62.59000  ? 93  VAL A HG12   1 
ATOM   1401 H HG13   . VAL A 1 93  ? 16.17400 10.35400  1.23200   1.000 62.59000  ? 93  VAL A HG13   1 
ATOM   1402 H HG21   . VAL A 1 93  ? 18.96800 10.76200  -0.98200  1.000 66.00000  ? 93  VAL A HG21   1 
ATOM   1403 H HG22   . VAL A 1 93  ? 18.56900 10.99400  0.53800   1.000 66.00000  ? 93  VAL A HG22   1 
ATOM   1404 H HG23   . VAL A 1 93  ? 19.06700 9.56400   0.05700   1.000 66.00000  ? 93  VAL A HG23   1 
ATOM   1405 N N      . ASN A 1 94  ? 14.92700 7.66800   -1.47400  1.000 65.24000  ? 94  ASN A N      1 
ATOM   1406 C CA     . ASN A 1 94  ? 13.47200 7.42300   -1.63600  1.000 67.67000  ? 94  ASN A CA     1 
ATOM   1407 C C      . ASN A 1 94  ? 13.14600 5.92900   -1.54400  1.000 68.51000  ? 94  ASN A C      1 
ATOM   1408 O O      . ASN A 1 94  ? 12.17900 5.60500   -0.87900  1.000 76.68000  ? 94  ASN A O      1 
ATOM   1409 C CB     . ASN A 1 94  ? 12.99200 8.10000   -2.90800  1.000 80.62000  ? 94  ASN A CB     1 
ATOM   1410 C CG     . ASN A 1 94  ? 13.14600 9.59900   -2.81500  1.000 90.41000  ? 94  ASN A CG     1 
ATOM   1411 O OD1    . ASN A 1 94  ? 13.73600 10.22400  -3.70200  1.000 78.05000  ? 94  ASN A OD1    1 
ATOM   1412 N ND2    . ASN A 1 94  ? 12.64700 10.19400  -1.74200  1.000 89.64000  ? 94  ASN A ND2    1 
ATOM   1413 H H      . ASN A 1 94  ? 15.44400 7.49600   -2.19300  1.000 78.68000  ? 94  ASN A H      1 
ATOM   1414 H HA     . ASN A 1 94  ? 12.99600 7.85300   -0.90100  1.000 81.59000  ? 94  ASN A HA     1 
ATOM   1415 H HB2    . ASN A 1 94  ? 13.51200 7.76700   -3.66600  1.000 97.12000  ? 94  ASN A HB2    1 
ATOM   1416 H HB3    . ASN A 1 94  ? 12.05200 7.87900   -3.05700  1.000 97.12000  ? 94  ASN A HB3    1 
ATOM   1417 H HD21   . ASN A 1 94  ? 11.80000 10.45200  -1.73300  1.000 107.95000 ? 94  ASN A HD21   1 
ATOM   1418 H HD22   . ASN A 1 94  ? 13.16100 10.31900  -1.02900  1.000 107.95000 ? 94  ASN A HD22   1 
ATOM   1419 N N      . ASN A 1 95  ? 13.87700 5.05500   -2.22000  1.000 64.72000  ? 95  ASN A N      1 
ATOM   1420 C CA     . ASN A 1 95  ? 13.57800 3.59900   -2.21600  1.000 63.48000  ? 95  ASN A CA     1 
ATOM   1421 C C      . ASN A 1 95  ? 13.69200 3.10700   -0.77700  1.000 74.96000  ? 95  ASN A C      1 
ATOM   1422 O O      . ASN A 1 95  ? 12.88400 2.24600   -0.39300  1.000 59.96000  ? 95  ASN A O      1 
ATOM   1423 C CB     . ASN A 1 95  ? 14.48400 2.80800   -3.14800  1.000 54.96000  ? 95  ASN A CB     1 
ATOM   1424 C CG     . ASN A 1 95  ? 14.17100 2.99200   -4.61000  1.000 59.07000  ? 95  ASN A CG     1 
ATOM   1425 O OD1    . ASN A 1 95  ? 13.04000 3.32000   -4.97800  1.000 73.61000  ? 95  ASN A OD1    1 
ATOM   1426 N ND2    . ASN A 1 95  ? 15.16000 2.76500   -5.46000  1.000 55.90000  ? 95  ASN A ND2    1 
ATOM   1427 H H      . ASN A 1 95  ? 14.57600 5.31900   -2.72000  1.000 78.05000  ? 95  ASN A H      1 
ATOM   1428 H HA     . ASN A 1 95  ? 12.65100 3.47100   -2.51100  1.000 76.56000  ? 95  ASN A HA     1 
ATOM   1429 H HB2    . ASN A 1 95  ? 15.41000 3.07500   -2.98700  1.000 66.33000  ? 95  ASN A HB2    1 
ATOM   1430 H HB3    . ASN A 1 95  ? 14.40900 1.85800   -2.92800  1.000 66.33000  ? 95  ASN A HB3    1 
ATOM   1431 H HD21   . ASN A 1 95  ? 15.66500 3.44000   -5.73900  1.000 67.46000  ? 95  ASN A HD21   1 
ATOM   1432 H HD22   . ASN A 1 95  ? 15.32800 1.93800   -5.73100  1.000 67.46000  ? 95  ASN A HD22   1 
ATOM   1433 N N      . LEU A 1 96  ? 14.66600 3.62000   -0.03100  1.000 63.37000  ? 96  LEU A N      1 
ATOM   1434 C CA     . LEU A 1 96  ? 14.87600 3.25800   1.38900   1.000 66.66000  ? 96  LEU A CA     1 
ATOM   1435 C C      . LEU A 1 96  ? 14.48600 4.49300   2.19800   1.000 75.07000  ? 96  LEU A C      1 
ATOM   1436 O O      . LEU A 1 96  ? 15.08600 5.55200   1.97000   1.000 76.34000  ? 96  LEU A O      1 
ATOM   1437 C CB     . LEU A 1 96  ? 16.31600 2.82100   1.63300   1.000 63.20000  ? 96  LEU A CB     1 
ATOM   1438 C CG     . LEU A 1 96  ? 16.94900 1.89400   0.59600   1.000 56.84000  ? 96  LEU A CG     1 
ATOM   1439 C CD1    . LEU A 1 96  ? 18.42200 1.75900   0.91500   1.000 55.24000  ? 96  LEU A CD1    1 
ATOM   1440 C CD2    . LEU A 1 96  ? 16.25600 0.55000   0.58300   1.000 49.96000  ? 96  LEU A CD2    1 
ATOM   1441 H H      . LEU A 1 96  ? 15.25300 4.21400   -0.37200  1.000 76.43000  ? 96  LEU A H      1 
ATOM   1442 H HA     . LEU A 1 96  ? 14.26800 2.51800   1.63000   1.000 80.37000  ? 96  LEU A HA     1 
ATOM   1443 H HB2    . LEU A 1 96  ? 16.87400 3.62800   1.70100   1.000 76.22000  ? 96  LEU A HB2    1 
ATOM   1444 H HB3    . LEU A 1 96  ? 16.35300 2.37100   2.50800   1.000 76.22000  ? 96  LEU A HB3    1 
ATOM   1445 H HG     . LEU A 1 96  ? 16.86100 2.30900   -0.30100  1.000 68.59000  ? 96  LEU A HG     1 
ATOM   1446 H HD11   . LEU A 1 96  ? 18.84900 1.19400   0.24900   1.000 66.66000  ? 96  LEU A HD11   1 
ATOM   1447 H HD12   . LEU A 1 96  ? 18.83800 2.63800   0.90900   1.000 66.66000  ? 96  LEU A HD12   1 
ATOM   1448 H HD13   . LEU A 1 96  ? 18.52800 1.35800   1.79500   1.000 66.66000  ? 96  LEU A HD13   1 
ATOM   1449 H HD21   . LEU A 1 96  ? 16.91300 -0.15300  0.45100   1.000 60.33000  ? 96  LEU A HD21   1 
ATOM   1450 H HD22   . LEU A 1 96  ? 15.80200 0.41100   1.43200   1.000 60.33000  ? 96  LEU A HD22   1 
ATOM   1451 H HD23   . LEU A 1 96  ? 15.60500 0.52600   -0.13900  1.000 60.33000  ? 96  LEU A HD23   1 
ATOM   1452 N N      . GLY A 1 97  ? 13.50500 4.37700   3.08600   1.000 76.16000  ? 97  GLY A N      1 
ATOM   1453 C CA     . GLY A 1 97  ? 12.96800 5.55000   3.79500   1.000 86.60000  ? 97  GLY A CA     1 
ATOM   1454 C C      . GLY A 1 97  ? 12.18500 6.39500   2.82000   1.000 85.65000  ? 97  GLY A C      1 
ATOM   1455 O O      . GLY A 1 97  ? 12.23700 6.10800   1.62700   1.000 84.17000  ? 97  GLY A O      1 
ATOM   1456 H H      . GLY A 1 97  ? 13.14200 3.57400   3.29100   1.000 91.78000  ? 97  GLY A H      1 
ATOM   1457 H HA2    . GLY A 1 97  ? 12.38100 5.25200   4.53000   1.000 104.30000 ? 97  GLY A HA2    1 
ATOM   1458 H HA3    . GLY A 1 97  ? 13.70800 6.07500   4.18100   1.000 104.30000 ? 97  GLY A HA3    1 
ATOM   1459 N N      . THR A 1 98  ? 11.43400 7.36500   3.31300   1.000 90.67000  ? 98  THR A N      1 
ATOM   1460 C CA     . THR A 1 98  ? 10.75200 8.25100   2.25100   1.000 91.35000  ? 98  THR A CA     1 
ATOM   1461 C C      . THR A 1 98  ? 9.97700  7.49600   1.17100   1.000 89.67000  ? 98  THR A C      1 
ATOM   1462 O O      . THR A 1 98  ? 9.80100  8.09700   0.10000   1.000 84.40000  ? 98  THR A O      1 
ATOM   1463 C CB     . THR A 1 98  ? 11.82200 9.15100   1.63900   1.000 93.55000  ? 98  THR A CB     1 
ATOM   1464 O OG1    . THR A 1 98  ? 12.82100 9.33900   2.63400   1.000 68.05000  ? 98  THR A OG1    1 
ATOM   1465 C CG2    . THR A 1 98  ? 11.29200 10.52100  1.26700   1.000 99.66000  ? 98  THR A CG2    1 
ATOM   1466 H H      A THR A 1 98  ? 11.41500 7.38400   4.23200   0.660 109.19000 ? 98  THR A H      1 
ATOM   1467 H H      B THR A 1 98  ? 11.41500 7.38400   4.23200   0.340 109.19000 ? 98  THR A H      1 
ATOM   1468 H HA     . THR A 1 98  ? 10.11700 8.82800   2.72200   1.000 110.00000 ? 98  THR A HA     1 
ATOM   1469 H HB     . THR A 1 98  ? 12.21400 8.72500   0.84100   1.000 112.65000 ? 98  THR A HB     1 
ATOM   1470 H HG1    . THR A 1 98  ? 13.58400 9.04800   2.34700   1.000 82.04000  ? 98  THR A HG1    1 
ATOM   1471 H HG21   . THR A 1 98  ? 10.62900 10.80000  1.92000   1.000 119.98000 ? 98  THR A HG21   1 
ATOM   1472 H HG22   . THR A 1 98  ? 12.02500 11.15800  1.25800   1.000 119.98000 ? 98  THR A HG22   1 
ATOM   1473 H HG23   . THR A 1 98  ? 10.88500 10.48500  0.38700   1.000 119.98000 ? 98  THR A HG23   1 
ATOM   1474 N N      . ILE A 1 99  ? 9.44300  6.29000   1.41200   1.000 99.33000  ? 99  ILE A N      1 
ATOM   1475 C CA     . ILE A 1 99  ? 8.58300  5.58300   0.40500   1.000 98.89000  ? 99  ILE A CA     1 
ATOM   1476 C C      . ILE A 1 99  ? 8.20000  4.16200   0.84700   1.000 118.74000 ? 99  ILE A C      1 
ATOM   1477 O O      . ILE A 1 99  ? 8.40000  3.87300   2.03900   1.000 105.18000 ? 99  ILE A O      1 
ATOM   1478 C CB     . ILE A 1 99  ? 9.28400  5.51100   -0.96000  1.000 70.68000  ? 99  ILE A CB     1 
ATOM   1479 H H      . ILE A 1 99  ? 9.56200  5.86300   2.19700   1.000 119.58000 ? 99  ILE A H      1 
ATOM   1480 H HA     . ILE A 1 99  ? 7.76100  6.09900   0.29600   1.000 119.05000 ? 99  ILE A HA     1 
ATOM   1481 N N      . ALA A 1 100 ? 7.61700  3.34300   -0.05000  1.000 130.18000 ? 100 ALA A N      1 
ATOM   1482 C CA     . ALA A 1 100 ? 7.23100  1.92400   0.19100   1.000 90.17000  ? 100 ALA A CA     1 
ATOM   1483 C C      . ALA A 1 100 ? 5.93700  1.82200   0.98600   1.000 98.36000  ? 100 ALA A C      1 
ATOM   1484 O O      . ALA A 1 100 ? 5.48600  0.69200   1.18400   1.000 102.16000 ? 100 ALA A O      1 
ATOM   1485 C CB     . ALA A 1 100 ? 8.32900  1.17700   0.89500   1.000 81.21000  ? 100 ALA A CB     1 
ATOM   1486 H H      . ALA A 1 100 ? 7.38700  3.62500   -0.87500  1.000 156.60000 ? 100 ALA A H      1 
ATOM   1487 H HA     . ALA A 1 100 ? 7.07500  1.49700   -0.69500  1.000 108.58000 ? 100 ALA A HA     1 
ATOM   1488 H HB1    . ALA A 1 100 ? 9.19300  1.52400   0.61800   1.000 97.83000  ? 100 ALA A HB1    1 
ATOM   1489 H HB2    . ALA A 1 100 ? 8.23100  1.28000   1.85600   1.000 97.83000  ? 100 ALA A HB2    1 
ATOM   1490 H HB3    . ALA A 1 100 ? 8.27600  0.23300   0.67000   1.000 97.83000  ? 100 ALA A HB3    1 
ATOM   1491 N N      . LYS A 1 101 ? 5.32400  2.93600   1.35500   1.000 96.64000  ? 101 LYS A N      1 
ATOM   1492 C CA     . LYS A 1 101 ? 4.13900  2.93600   2.24700   1.000 101.18000 ? 101 LYS A CA     1 
ATOM   1493 C C      . LYS A 1 101 ? 3.07800  1.91000   1.83900   1.000 93.59000  ? 101 LYS A C      1 
ATOM   1494 O O      . LYS A 1 101 ? 2.44900  1.35800   2.74400   1.000 96.59000  ? 101 LYS A O      1 
ATOM   1495 C CB     . LYS A 1 101 ? 3.50800  4.32800   2.20100   1.000 75.75000  ? 101 LYS A CB     1 
ATOM   1496 H H      . LYS A 1 101 ? 5.58100  3.74300   1.04800   1.000 116.35000 ? 101 LYS A H      1 
ATOM   1497 H HA     . LYS A 1 101 ? 4.44000  2.73500   3.17000   1.000 121.80000 ? 101 LYS A HA     1 
ATOM   1498 N N      . SER A 1 102 ? 2.85300  1.68600   0.54900   1.000 105.42000 ? 102 SER A N      1 
ATOM   1499 C CA     . SER A 1 102 ? 1.77100  0.81300   0.10200   1.000 108.21000 ? 102 SER A CA     1 
ATOM   1500 C C      . SER A 1 102 ? 1.91600  -0.56900  0.73200   1.000 94.98000  ? 102 SER A C      1 
ATOM   1501 O O      . SER A 1 102 ? 1.05100  -1.02400  1.48900   1.000 93.48000  ? 102 SER A O      1 
ATOM   1502 C CB     . SER A 1 102 ? 1.75100  0.71900   -1.43000  1.000 98.47000  ? 102 SER A CB     1 
ATOM   1503 O OG     . SER A 1 102 ? 3.03900  0.47300   -1.96100  1.000 98.45000  ? 102 SER A OG     1 
ATOM   1504 H H      . SER A 1 102 ? 3.33800  2.01700   -0.08000  1.000 126.88000 ? 102 SER A H      1 
ATOM   1505 H HA     . SER A 1 102 ? 0.92200  1.19400   0.37700   1.000 130.23000 ? 102 SER A HA     1 
ATOM   1506 H HB2    . SER A 1 102 ? 1.16300  -0.00800  -1.68900  1.000 118.54000 ? 102 SER A HB2    1 
ATOM   1507 H HB3    . SER A 1 102 ? 1.42100  1.55700   -1.78900  1.000 118.54000 ? 102 SER A HB3    1 
ATOM   1508 H HG     . SER A 1 102 ? 3.22100  -0.34500  -1.90500  1.000 118.52000 ? 102 SER A HG     1 
ATOM   1509 N N      . GLY A 1 103 ? 3.03600  -1.23400  0.44900   1.000 98.33000  ? 103 GLY A N      1 
ATOM   1510 C CA     . GLY A 1 103 ? 3.24500  -2.58800  0.92700   1.000 75.35000  ? 103 GLY A CA     1 
ATOM   1511 C C      . GLY A 1 103 ? 3.27800  -2.69800  2.43900   1.000 69.38000  ? 103 GLY A C      1 
ATOM   1512 O O      . GLY A 1 103 ? 2.87500  -3.71900  3.00100   1.000 75.77000  ? 103 GLY A O      1 
ATOM   1513 H H      . GLY A 1 103 ? 3.68700  -0.92000  -0.01700  1.000 118.38000 ? 103 GLY A H      1 
ATOM   1514 H HA2    . GLY A 1 103 ? 2.52700  -3.15300  0.60000   1.000 90.80000  ? 103 GLY A HA2    1 
ATOM   1515 H HA3    . GLY A 1 103 ? 4.08900  -2.91800  0.58300   1.000 90.80000  ? 103 GLY A HA3    1 
ATOM   1516 N N      . THR A 1 104 ? 3.74600  -1.65500  3.12500   1.000 72.53000  ? 104 THR A N      1 
ATOM   1517 C CA     . THR A 1 104 ? 3.95900  -1.79500  4.56400   1.000 73.56000  ? 104 THR A CA     1 
ATOM   1518 C C      . THR A 1 104 ? 2.63900  -1.78300  5.32300   1.000 70.16000  ? 104 THR A C      1 
ATOM   1519 O O      . THR A 1 104 ? 2.49800  -2.45700  6.35000   1.000 84.83000  ? 104 THR A O      1 
ATOM   1520 C CB     . THR A 1 104 ? 4.87100  -0.70000  5.13900   1.000 50.17000  ? 104 THR A CB     1 
ATOM   1521 O OG1    . THR A 1 104 ? 4.14000  0.52200   5.25300   1.000 86.79000  ? 104 THR A OG1    1 
ATOM   1522 C CG2    . THR A 1 104 ? 6.09200  -0.50400  4.22700   1.000 63.21000  ? 104 THR A CG2    1 
ATOM   1523 H H      . THR A 1 104 ? 3.94100  -0.88600  2.79400   1.000 87.42000  ? 104 THR A H      1 
ATOM   1524 H HA     . THR A 1 104 ? 4.41100  -2.64400  4.69100   1.000 88.65000  ? 104 THR A HA     1 
ATOM   1525 H HB     . THR A 1 104 ? 5.18600  -0.95700  6.02000   1.000 60.59000  ? 104 THR A HB     1 
ATOM   1526 H HG1    . THR A 1 104 ? 4.65100  1.17600   5.12400   1.000 104.54000 ? 104 THR A HG1    1 
ATOM   1527 H HG21   . THR A 1 104 ? 6.49600  0.36200   4.39500   1.000 76.23000  ? 104 THR A HG21   1 
ATOM   1528 H HG22   . THR A 1 104 ? 6.74900  -1.19600  4.40000   1.000 76.23000  ? 104 THR A HG22   1 
ATOM   1529 H HG23   . THR A 1 104 ? 5.82200  -0.55100  3.29700   1.000 76.23000  ? 104 THR A HG23   1 
ATOM   1530 N N      . LYS A 1 105 ? 1.66900  -0.99000  4.87700   1.000 79.92000  ? 105 LYS A N      1 
ATOM   1531 C CA     . LYS A 1 105 ? 0.36800  -1.01200  5.54800   1.000 59.13000  ? 105 LYS A CA     1 
ATOM   1532 C C      . LYS A 1 105 ? -0.29900 -2.36000  5.31100   1.000 67.47000  ? 105 LYS A C      1 
ATOM   1533 O O      . LYS A 1 105 ? -0.71500 -3.03400  6.26000   1.000 63.06000  ? 105 LYS A O      1 
ATOM   1534 C CB     . LYS A 1 105 ? -0.51500 0.13600   5.06300   1.000 56.54000  ? 105 LYS A CB     1 
ATOM   1535 H H      . LYS A 1 105 ? 1.73300  -0.44800  4.21200   1.000 96.28000  ? 105 LYS A H      1 
ATOM   1536 H HA     . LYS A 1 105 ? 0.49000  -0.88000  6.50100   1.000 71.34000  ? 105 LYS A HA     1 
ATOM   1537 N N      . SER A 1 106 ? -0.34900 -2.80300  4.04900   1.000 65.15000  ? 106 SER A N      1 
ATOM   1538 C CA     . SER A 1 106 ? -0.91100 -4.11900  3.75400   1.000 44.76000  ? 106 SER A CA     1 
ATOM   1539 C C      . SER A 1 106 ? -0.25900 -5.19500  4.60400   1.000 60.47000  ? 106 SER A C      1 
ATOM   1540 O O      . SER A 1 106 ? -0.93000 -6.05800  5.18000   1.000 52.47000  ? 106 SER A O      1 
ATOM   1541 C CB     . SER A 1 106 ? -0.74200 -4.44900  2.26100   1.000 49.86000  ? 106 SER A CB     1 
ATOM   1542 O OG     . SER A 1 106 ? -1.93500 -4.16100  1.53700   1.000 75.98000  ? 106 SER A OG     1 
ATOM   1543 H H      . SER A 1 106 ? -0.06900 -2.36800  3.36200   1.000 78.57000  ? 106 SER A H      1 
ATOM   1544 H HA     . SER A 1 106 ? -1.86000 -4.09900  3.95400   1.000 54.10000  ? 106 SER A HA     1 
ATOM   1545 H HB2    . SER A 1 106 ? -0.01700 -3.91500  1.90000   1.000 60.22000  ? 106 SER A HB2    1 
ATOM   1546 H HB3    . SER A 1 106 ? -0.53600 -5.39200  2.16800   1.000 60.22000  ? 106 SER A HB3    1 
ATOM   1547 H HG     . SER A 1 106 ? -1.83900 -4.36900  0.72900   1.000 91.56000  ? 106 SER A HG     1 
ATOM   1548 N N      . PHE A 1 107 ? 1.06100  -5.15500  4.69300   1.000 64.13000  ? 107 PHE A N      1 
ATOM   1549 C CA     . PHE A 1 107 ? 1.78200  -6.21600  5.37100   1.000 57.03000  ? 107 PHE A CA     1 
ATOM   1550 C C      . PHE A 1 107 ? 1.52600  -6.20300  6.87700   1.000 51.43000  ? 107 PHE A C      1 
ATOM   1551 O O      . PHE A 1 107 ? 1.34700  -7.25700  7.49500   1.000 54.09000  ? 107 PHE A O      1 
ATOM   1552 C CB     . PHE A 1 107 ? 3.28700  -6.10500  5.06600   1.000 51.05000  ? 107 PHE A CB     1 
ATOM   1553 C CG     . PHE A 1 107 ? 4.10400  -7.10800  5.79400   1.000 47.12000  ? 107 PHE A CG     1 
ATOM   1554 C CD1    . PHE A 1 107 ? 3.95900  -8.46200  5.50600   1.000 68.11000  ? 107 PHE A CD1    1 
ATOM   1555 C CD2    . PHE A 1 107 ? 4.99200  -6.72000  6.79000   1.000 51.18000  ? 107 PHE A CD2    1 
ATOM   1556 C CE1    . PHE A 1 107 ? 4.67000  -9.42200  6.21100   1.000 57.47000  ? 107 PHE A CE1    1 
ATOM   1557 C CE2    . PHE A 1 107 ? 5.71800  -7.67100  7.48800   1.000 51.28000  ? 107 PHE A CE2    1 
ATOM   1558 C CZ     . PHE A 1 107 ? 5.54400  -9.02300  7.20600   1.000 42.27000  ? 107 PHE A CZ     1 
ATOM   1559 H H      . PHE A 1 107 ? 1.55900  -4.53100  4.37200   1.000 77.34000  ? 107 PHE A H      1 
ATOM   1560 H HA     . PHE A 1 107 ? 1.46800  -7.06900  5.03400   1.000 68.81000  ? 107 PHE A HA     1 
ATOM   1561 H HB2    . PHE A 1 107 ? 3.42600  -6.24000  4.11500   1.000 61.64000  ? 107 PHE A HB2    1 
ATOM   1562 H HB3    . PHE A 1 107 ? 3.59600  -5.22300  5.32400   1.000 61.64000  ? 107 PHE A HB3    1 
ATOM   1563 H HD1    . PHE A 1 107 ? 3.37700  -8.72600  4.83100   1.000 82.11000  ? 107 PHE A HD1    1 
ATOM   1564 H HD2    . PHE A 1 107 ? 5.09800  -5.81800  6.98900   1.000 61.79000  ? 107 PHE A HD2    1 
ATOM   1565 H HE1    . PHE A 1 107 ? 4.56000  -10.32400 6.01700   1.000 69.35000  ? 107 PHE A HE1    1 
ATOM   1566 H HE2    . PHE A 1 107 ? 6.32200  -7.40600  8.14500   1.000 61.92000  ? 107 PHE A HE2    1 
ATOM   1567 H HZ     . PHE A 1 107 ? 6.01700  -9.66200  7.68900   1.000 51.11000  ? 107 PHE A HZ     1 
ATOM   1568 N N      . MET A 1 108 ? 1.55200  -5.04000  7.50400   1.000 50.98000  ? 108 MET A N      1 
ATOM   1569 C CA     . MET A 1 108 ? 1.25400  -5.01000  8.92900   1.000 58.39000  ? 108 MET A CA     1 
ATOM   1570 C C      . MET A 1 108 ? -0.13600 -5.59200  9.20300   1.000 46.16000  ? 108 MET A C      1 
ATOM   1571 O O      . MET A 1 108 ? -0.32100 -6.33000  10.17400  1.000 50.47000  ? 108 MET A O      1 
ATOM   1572 C CB     . MET A 1 108 ? 1.44300  -3.57800  9.45700   1.000 65.15000  ? 108 MET A CB     1 
ATOM   1573 C CG     . MET A 1 108 ? 2.94000  -3.19000  9.55200   1.000 73.19000  ? 108 MET A CG     1 
ATOM   1574 S SD     . MET A 1 108 ? 3.39800  -1.84600  10.65300  1.000 80.68000  ? 108 MET A SD     1 
ATOM   1575 C CE     . MET A 1 108 ? 2.46500  -0.48700  9.97200   1.000 71.89000  ? 108 MET A CE     1 
ATOM   1576 H H      . MET A 1 108 ? 1.73200  -4.28000  7.14400   1.000 61.55000  ? 108 MET A H      1 
ATOM   1577 H HA     . MET A 1 108 ? 1.88500  -5.55300  9.42600   1.000 70.45000  ? 108 MET A HA     1 
ATOM   1578 H HB2    . MET A 1 108 ? 1.00500  -2.95600  8.85500   1.000 78.57000  ? 108 MET A HB2    1 
ATOM   1579 H HB3    . MET A 1 108 ? 1.05400  -3.51200  10.34400  1.000 78.57000  ? 108 MET A HB3    1 
ATOM   1580 H HG2    . MET A 1 108 ? 3.42900  -3.97200  9.85200   1.000 88.21000  ? 108 MET A HG2    1 
ATOM   1581 H HG3    . MET A 1 108 ? 3.23500  -2.93400  8.66500   1.000 88.21000  ? 108 MET A HG3    1 
ATOM   1582 H HE1    . MET A 1 108 ? 2.57500  0.29000   10.54200  1.000 86.66000  ? 108 MET A HE1    1 
ATOM   1583 H HE2    . MET A 1 108 ? 2.79500  -0.29200  9.08000   1.000 86.66000  ? 108 MET A HE2    1 
ATOM   1584 H HE3    . MET A 1 108 ? 1.52800  -0.73600  9.93000   1.000 86.66000  ? 108 MET A HE3    1 
ATOM   1585 N N      . GLU A 1 109 ? -1.09500 -5.36200  8.31500   1.000 57.55000  ? 109 GLU A N      1 
ATOM   1586 C CA     . GLU A 1 109 ? -2.43900 -5.91100  8.50000   1.000 56.78000  ? 109 GLU A CA     1 
ATOM   1587 C C      . GLU A 1 109 ? -2.47400 -7.41800  8.27600   1.000 49.20000  ? 109 GLU A C      1 
ATOM   1588 O O      . GLU A 1 109 ? -3.09800 -8.17500  9.03800   1.000 45.05000  ? 109 GLU A O      1 
ATOM   1589 C CB     . GLU A 1 109 ? -3.39900 -5.19400  7.55600   1.000 48.17000  ? 109 GLU A CB     1 
ATOM   1590 C CG     . GLU A 1 109 ? -3.43000 -3.66300  7.78600   1.000 59.52000  ? 109 GLU A CG     1 
ATOM   1591 C CD     . GLU A 1 109 ? -4.62800 -2.97600  7.10900   1.000 89.70000  ? 109 GLU A CD     1 
ATOM   1592 O OE1    . GLU A 1 109 ? -4.72900 -2.99000  5.85700   1.000 92.93000  ? 109 GLU A OE1    1 
ATOM   1593 O OE2    . GLU A 1 109 ? -5.47900 -2.42100  7.83900   1.000 95.46000  ? 109 GLU A OE2    1 
ATOM   1594 H H      . GLU A 1 109 ? -0.99900 -4.89600  7.59900   1.000 69.44000  ? 109 GLU A H      1 
ATOM   1595 H HA     . GLU A 1 109 ? -2.72500 -5.75600  9.41400   1.000 68.52000  ? 109 GLU A HA     1 
ATOM   1596 H HB2    . GLU A 1 109 ? -3.12200 -5.35500  6.64100   1.000 58.19000  ? 109 GLU A HB2    1 
ATOM   1597 H HB3    . GLU A 1 109 ? -4.29600 -5.53700  7.69600   1.000 58.19000  ? 109 GLU A HB3    1 
ATOM   1598 H HG2    . GLU A 1 109 ? -3.48500 -3.48900  8.73900   1.000 71.81000  ? 109 GLU A HG2    1 
ATOM   1599 H HG3    . GLU A 1 109 ? -2.61800 -3.27400  7.42400   1.000 71.81000  ? 109 GLU A HG3    1 
ATOM   1600 N N      . ALA A 1 110 ? -1.77800 -7.89200  7.26800   1.000 49.18000  ? 110 ALA A N      1 
ATOM   1601 C CA     . ALA A 1 110 ? -1.78200 -9.32500  7.08500   1.000 40.25000  ? 110 ALA A CA     1 
ATOM   1602 C C      . ALA A 1 110 ? -1.18200 -10.01600 8.30100   1.000 53.17000  ? 110 ALA A C      1 
ATOM   1603 O O      . ALA A 1 110 ? -1.61800 -11.11900 8.65800   1.000 57.93000  ? 110 ALA A O      1 
ATOM   1604 C CB     . ALA A 1 110 ? -1.03400 -9.70800  5.80400   1.000 41.40000  ? 110 ALA A CB     1 
ATOM   1605 H H      . ALA A 1 110 ? -1.31800 -7.43200  6.70500   1.000 59.40000  ? 110 ALA A H      1 
ATOM   1606 H HA     . ALA A 1 110 ? -2.69400 -9.63500  6.97600   1.000 48.68000  ? 110 ALA A HA     1 
ATOM   1607 H HB1    . ALA A 1 110 ? -1.00000 -10.67500 5.73500   1.000 50.06000  ? 110 ALA A HB1    1 
ATOM   1608 H HB2    . ALA A 1 110 ? -1.50500 -9.33900  5.04100   1.000 50.06000  ? 110 ALA A HB2    1 
ATOM   1609 H HB3    . ALA A 1 110 ? -0.13400 -9.34700  5.84300   1.000 50.06000  ? 110 ALA A HB3    1 
ATOM   1610 N N      . LEU A 1 111 ? -0.18400 -9.38900  8.95800   1.000 44.51000  ? 111 LEU A N      1 
ATOM   1611 C CA     . LEU A 1 111 ? 0.45400  -10.05500 10.10400  1.000 49.64000  ? 111 LEU A CA     1 
ATOM   1612 C C      . LEU A 1 111 ? -0.53100 -10.20600 11.26300  1.000 57.01000  ? 111 LEU A C      1 
ATOM   1613 O O      . LEU A 1 111 ? -0.64400 -11.28300 11.86700  1.000 49.98000  ? 111 LEU A O      1 
ATOM   1614 C CB     . LEU A 1 111 ? 1.68600  -9.28800  10.58000  1.000 53.58000  ? 111 LEU A CB     1 
ATOM   1615 C CG     . LEU A 1 111 ? 2.98800  -9.45700  9.80700   1.000 52.04000  ? 111 LEU A CG     1 
ATOM   1616 C CD1    . LEU A 1 111 ? 3.99500  -8.47100  10.44800  1.000 46.17000  ? 111 LEU A CD1    1 
ATOM   1617 C CD2    . LEU A 1 111 ? 3.47300  -10.86300 9.75700   1.000 47.86000  ? 111 LEU A CD2    1 
ATOM   1618 H H      . LEU A 1 111 ? 0.12600  -8.61100  8.76500   1.000 53.79000  ? 111 LEU A H      1 
ATOM   1619 H HA     . LEU A 1 111 ? 0.74500  -10.93200 9.80800   1.000 59.95000  ? 111 LEU A HA     1 
ATOM   1620 H HB2    . LEU A 1 111 ? 1.47000  -8.34300  10.55600  1.000 64.68000  ? 111 LEU A HB2    1 
ATOM   1621 H HB3    . LEU A 1 111 ? 1.86800  -9.56300  11.49200  1.000 64.68000  ? 111 LEU A HB3    1 
ATOM   1622 H HG     . LEU A 1 111 ? 2.86800  -9.25100  8.86700   1.000 62.83000  ? 111 LEU A HG     1 
ATOM   1623 H HD11   . LEU A 1 111 ? 4.84100  -8.53300  9.97700   1.000 55.78000  ? 111 LEU A HD11   1 
ATOM   1624 H HD12   . LEU A 1 111 ? 3.64300  -7.57000  10.37700  1.000 55.78000  ? 111 LEU A HD12   1 
ATOM   1625 H HD13   . LEU A 1 111 ? 4.11800  -8.70600  11.38100  1.000 55.78000  ? 111 LEU A HD13   1 
ATOM   1626 H HD21   . LEU A 1 111 ? 4.31200  -10.89000 9.27200   1.000 57.81000  ? 111 LEU A HD21   1 
ATOM   1627 H HD22   . LEU A 1 111 ? 3.60300  -11.18400 10.66200  1.000 57.81000  ? 111 LEU A HD22   1 
ATOM   1628 H HD23   . LEU A 1 111 ? 2.81100  -11.40900 9.30400   1.000 57.81000  ? 111 LEU A HD23   1 
ATOM   1629 N N      . SER A 1 112 ? -1.25700 -9.12400  11.58500  1.000 52.85000  ? 112 SER A N      1 
ATOM   1630 C CA     . SER A 1 112 ? -2.27000 -9.16900  12.63900  1.000 54.18000  ? 112 SER A CA     1 
ATOM   1631 C C      . SER A 1 112 ? -3.33200 -10.24200 12.35300  1.000 50.79000  ? 112 SER A C      1 
ATOM   1632 O O      . SER A 1 112 ? -3.94900 -10.77200 13.27800  1.000 58.17000  ? 112 SER A O      1 
ATOM   1633 C CB     . SER A 1 112 ? -2.90400 -7.79200  12.78600  1.000 43.60000  ? 112 SER A CB     1 
ATOM   1634 O OG     . SER A 1 112 ? -3.97000 -7.64100  11.86400  1.000 72.37000  ? 112 SER A OG     1 
ATOM   1635 H H      . SER A 1 112 ? -1.18000 -8.35500  11.20700  1.000 63.81000  ? 112 SER A H      1 
ATOM   1636 H HA     . SER A 1 112 ? -1.85100 -9.39800  13.48400  1.000 65.39000  ? 112 SER A HA     1 
ATOM   1637 H HB2    . SER A 1 112 ? -3.24800 -7.69500  13.68800  1.000 52.71000  ? 112 SER A HB2    1 
ATOM   1638 H HB3    . SER A 1 112 ? -2.23400 -7.11200  12.61200  1.000 52.71000  ? 112 SER A HB3    1 
ATOM   1639 H HG     . SER A 1 112 ? -4.40300 -6.94200  12.03700  1.000 87.22000  ? 112 SER A HG     1 
ATOM   1640 N N      . ALA A 1 113 ? -3.56400 -10.58500 11.09300  1.000 50.35000  ? 113 ALA A N      1 
ATOM   1641 C CA     . ALA A 1 113 ? -4.50800 -11.66200 10.77500  1.000 47.75000  ? 113 ALA A CA     1 
ATOM   1642 C C      . ALA A 1 113 ? -3.88900 -13.06900 10.81900  1.000 51.40000  ? 113 ALA A C      1 
ATOM   1643 O O      . ALA A 1 113 ? -4.60300 -14.05000 10.57400  1.000 47.74000  ? 113 ALA A O      1 
ATOM   1644 C CB     . ALA A 1 113 ? -5.13200 -11.42600 9.37900   1.000 39.37000  ? 113 ALA A CB     1 
ATOM   1645 H H      . ALA A 1 113 ? -3.19500 -10.21600 10.40900  1.000 60.81000  ? 113 ALA A H      1 
ATOM   1646 H HA     . ALA A 1 113 ? -5.21500 -11.63900 11.43800  1.000 57.68000  ? 113 ALA A HA     1 
ATOM   1647 H HB1    . ALA A 1 113 ? -5.81600 -12.09600 9.22200   1.000 47.62000  ? 113 ALA A HB1    1 
ATOM   1648 H HB2    . ALA A 1 113 ? -5.52600 -10.54000 9.35500   1.000 47.62000  ? 113 ALA A HB2    1 
ATOM   1649 H HB3    . ALA A 1 113 ? -4.43800 -11.49900 8.70600   1.000 47.62000  ? 113 ALA A HB3    1 
ATOM   1650 N N      . GLY A 1 114 ? -2.57900 -13.18500 11.07700  1.000 51.62000  ? 114 GLY A N      1 
ATOM   1651 C CA     . GLY A 1 114 ? -1.98000 -14.49900 11.19700  1.000 48.51000  ? 114 GLY A CA     1 
ATOM   1652 C C      . GLY A 1 114 ? -0.91600 -14.86400 10.16100  1.000 37.19000  ? 114 GLY A C      1 
ATOM   1653 O O      . GLY A 1 114 ? -0.37400 -15.98000 10.13600  1.000 39.29000  ? 114 GLY A O      1 
ATOM   1654 H H      . GLY A 1 114 ? -2.03600 -12.52600 11.18300  1.000 62.33000  ? 114 GLY A H      1 
ATOM   1655 H HA2    . GLY A 1 114 ? -1.56500 -14.56600 12.07100  1.000 58.60000  ? 114 GLY A HA2    1 
ATOM   1656 H HA3    . GLY A 1 114 ? -2.68500 -15.16200 11.13100  1.000 58.60000  ? 114 GLY A HA3    1 
ATOM   1657 N N      . ALA A 1 115 ? -0.57700 -13.88400 9.32800   1.000 42.61000  ? 115 ALA A N      1 
ATOM   1658 C CA     . ALA A 1 115 ? 0.31900  -14.15100 8.21300   1.000 58.55000  ? 115 ALA A CA     1 
ATOM   1659 C C      . ALA A 1 115 ? 1.70400  -14.53500 8.72800   1.000 54.66000  ? 115 ALA A C      1 
ATOM   1660 O O      . ALA A 1 115 ? 2.16100  -14.06200 9.78900   1.000 36.94000  ? 115 ALA A O      1 
ATOM   1661 C CB     . ALA A 1 115 ? 0.41900  -12.93800 7.30300   1.000 55.61000  ? 115 ALA A CB     1 
ATOM   1662 H H      . ALA A 1 115 ? -0.84900 -13.07000 9.38700   1.000 51.51000  ? 115 ALA A H      1 
ATOM   1663 H HA     . ALA A 1 115 ? -0.02900 -14.88700 7.68600   1.000 70.64000  ? 115 ALA A HA     1 
ATOM   1664 H HB1    . ALA A 1 115 ? 1.02500  -13.14100 6.57300   1.000 67.12000  ? 115 ALA A HB1    1 
ATOM   1665 H HB2    . ALA A 1 115 ? -0.46200 -12.73200 6.95400   1.000 67.12000  ? 115 ALA A HB2    1 
ATOM   1666 H HB3    . ALA A 1 115 ? 0.75700  -12.18700 7.81500   1.000 67.12000  ? 115 ALA A HB3    1 
ATOM   1667 N N      . ASP A 1 116 ? 2.36600  -15.41700 7.98300   1.000 55.30000  ? 116 ASP A N      1 
ATOM   1668 C CA     . ASP A 1 116 ? 3.70900  -15.82600 8.37300   1.000 82.38000  ? 116 ASP A CA     1 
ATOM   1669 C C      . ASP A 1 116 ? 4.73900  -14.80900 7.86200   1.000 66.99000  ? 116 ASP A C      1 
ATOM   1670 O O      . ASP A 1 116 ? 4.73900  -14.44000 6.68200   1.000 49.85000  ? 116 ASP A O      1 
ATOM   1671 C CB     . ASP A 1 116 ? 4.02000  -17.23900 7.86600   1.000 70.64000  ? 116 ASP A CB     1 
ATOM   1672 C CG     . ASP A 1 116 ? 5.07200  -17.92700 8.71700   1.000 75.66000  ? 116 ASP A CG     1 
ATOM   1673 O OD1    . ASP A 1 116 ? 6.20100  -17.39800 8.74700   1.000 70.02000  ? 116 ASP A OD1    1 
ATOM   1674 O OD2    . ASP A 1 116 ? 4.76100  -18.94800 9.37900   1.000 85.83000  ? 116 ASP A OD2    1 
ATOM   1675 H H      . ASP A 1 116 ? 2.06600  -15.78400 7.26600   1.000 66.74000  ? 116 ASP A H      1 
ATOM   1676 H HA     . ASP A 1 116 ? 3.77000  -15.85000 9.34000   1.000 99.24000  ? 116 ASP A HA     1 
ATOM   1677 H HB2    . ASP A 1 116 ? 3.21100  -17.77400 7.89200   1.000 85.15000  ? 116 ASP A HB2    1 
ATOM   1678 H HB3    . ASP A 1 116 ? 4.35300  -17.18600 6.95600   1.000 85.15000  ? 116 ASP A HB3    1 
ATOM   1679 N N      . VAL A 1 117 ? 5.62600  -14.38000 8.76700   1.000 57.11000  ? 117 VAL A N      1 
ATOM   1680 C CA     . VAL A 1 117 ? 6.63200  -13.37900 8.45400   1.000 58.08000  ? 117 VAL A CA     1 
ATOM   1681 C C      . VAL A 1 117 ? 7.34100  -13.69700 7.15900   1.000 60.75000  ? 117 VAL A C      1 
ATOM   1682 O O      . VAL A 1 117 ? 7.81300  -12.78700 6.46000   1.000 52.96000  ? 117 VAL A O      1 
ATOM   1683 C CB     . VAL A 1 117 ? 7.64600  -13.26300 9.60100   1.000 52.56000  ? 117 VAL A CB     1 
ATOM   1684 C CG1    . VAL A 1 117 ? 8.78600  -12.37800 9.17900   1.000 57.93000  ? 117 VAL A CG1    1 
ATOM   1685 C CG2    . VAL A 1 117 ? 7.01700  -12.70400 10.83800  1.000 63.17000  ? 117 VAL A CG2    1 
ATOM   1686 H H      . VAL A 1 117 ? 5.66200  -14.66000 9.57900   1.000 68.91000  ? 117 VAL A H      1 
ATOM   1687 H HA     . VAL A 1 117 ? 6.17600  -12.52800 8.35200   1.000 70.08000  ? 117 VAL A HA     1 
ATOM   1688 H HB     . VAL A 1 117 ? 7.97400  -14.15200 9.80700   1.000 63.45000  ? 117 VAL A HB     1 
ATOM   1689 H HG11   . VAL A 1 117 ? 9.27300  -12.09300 9.96700   1.000 69.90000  ? 117 VAL A HG11   1 
ATOM   1690 H HG12   . VAL A 1 117 ? 9.37200  -12.87700 8.58900   1.000 69.90000  ? 117 VAL A HG12   1 
ATOM   1691 H HG13   . VAL A 1 117 ? 8.43000  -11.60400 8.71300   1.000 69.90000  ? 117 VAL A HG13   1 
ATOM   1692 H HG21   . VAL A 1 117 ? 7.69700  -12.61100 11.52300  1.000 76.18000  ? 117 VAL A HG21   1 
ATOM   1693 H HG22   . VAL A 1 117 ? 6.63300  -11.83700 10.63300  1.000 76.18000  ? 117 VAL A HG22   1 
ATOM   1694 H HG23   . VAL A 1 117 ? 6.32300  -13.31000 11.14000  1.000 76.18000  ? 117 VAL A HG23   1 
ATOM   1695 N N      . SER A 1 118 ? 7.44300  -14.97500 6.82100   1.000 51.05000  ? 118 SER A N      1 
ATOM   1696 C CA     . SER A 1 118 ? 8.06800  -15.37100 5.56400   1.000 58.53000  ? 118 SER A CA     1 
ATOM   1697 C C      . SER A 1 118 ? 7.31200  -14.92300 4.33000   1.000 62.79000  ? 118 SER A C      1 
ATOM   1698 O O      . SER A 1 118 ? 7.77400  -15.20500 3.21400   1.000 63.80000  ? 118 SER A O      1 
ATOM   1699 C CB     . SER A 1 118 ? 8.19700  -16.88900 5.51600   1.000 61.55000  ? 118 SER A CB     1 
ATOM   1700 O OG     . SER A 1 118 ? 6.96200  -17.42900 5.92100   1.000 62.23000  ? 118 SER A OG     1 
ATOM   1701 H H      . SER A 1 118 ? 7.16000  -15.63100 7.29900   1.000 61.64000  ? 118 SER A H      1 
ATOM   1702 H HA     . SER A 1 118 ? 8.94900  -14.96600 5.53600   1.000 70.62000  ? 118 SER A HA     1 
ATOM   1703 H HB2    . SER A 1 118 ? 8.40100  -17.17400 4.61200   1.000 74.24000  ? 118 SER A HB2    1 
ATOM   1704 H HB3    . SER A 1 118 ? 8.89800  -17.17900 6.12100   1.000 74.24000  ? 118 SER A HB3    1 
ATOM   1705 H HG     . SER A 1 118 ? 7.02300  -18.26400 5.99200   1.000 75.06000  ? 118 SER A HG     1 
ATOM   1706 N N      . MET A 1 119 ? 6.14600  -14.30700 4.47600   1.000 61.86000  ? 119 MET A N      1 
ATOM   1707 C CA     . MET A 1 119 ? 5.32600  -13.86400 3.35700   1.000 66.84000  ? 119 MET A CA     1 
ATOM   1708 C C      . MET A 1 119 ? 5.54800  -12.38200 3.09700   1.000 55.92000  ? 119 MET A C      1 
ATOM   1709 O O      . MET A 1 119 ? 4.90500  -11.81300 2.22600   1.000 64.36000  ? 119 MET A O      1 
ATOM   1710 C CB     . MET A 1 119 ? 3.87100  -14.22500 3.67000   1.000 68.38000  ? 119 MET A CB     1 
ATOM   1711 C CG     . MET A 1 119 ? 2.77600  -13.58500 2.83400   1.000 89.22000  ? 119 MET A CG     1 
ATOM   1712 S SD     . MET A 1 119 ? 1.21600  -14.51600 3.03200   1.000 105.02000 ? 119 MET A SD     1 
ATOM   1713 C CE     . MET A 1 119 ? -0.00600 -13.32000 2.42700   1.000 74.59000  ? 119 MET A CE     1 
ATOM   1714 H H      . MET A 1 119 ? 5.79700  -14.12700 5.24100   1.000 74.62000  ? 119 MET A H      1 
ATOM   1715 H HA     . MET A 1 119 ? 5.53900  -14.32500 2.53100   1.000 80.59000  ? 119 MET A HA     1 
ATOM   1716 H HB2    . MET A 1 119 ? 3.77700  -15.18500 3.56200   1.000 82.44000  ? 119 MET A HB2    1 
ATOM   1717 H HB3    . MET A 1 119 ? 3.69700  -13.97600 4.59100   1.000 82.44000  ? 119 MET A HB3    1 
ATOM   1718 H HG2    . MET A 1 119 ? 2.63300  -12.67200 3.12800   1.000 107.45000 ? 119 MET A HG2    1 
ATOM   1719 H HG3    . MET A 1 119 ? 3.03000  -13.59700 1.89800   1.000 107.45000 ? 119 MET A HG3    1 
ATOM   1720 H HE1    . MET A 1 119 ? -0.88500 -13.73000 2.44500   1.000 89.89000  ? 119 MET A HE1    1 
ATOM   1721 H HE2    . MET A 1 119 ? 0.00600  -12.53800 3.00100   1.000 89.89000  ? 119 MET A HE2    1 
ATOM   1722 H HE3    . MET A 1 119 ? 0.22200  -13.06600 1.51900   1.000 89.89000  ? 119 MET A HE3    1 
ATOM   1723 N N      . ILE A 1 120 ? 6.55500  -11.79500 3.75000   1.000 60.67000  ? 120 ILE A N      1 
ATOM   1724 C CA     . ILE A 1 120 ? 6.84500  -10.36800 3.64000   1.000 60.22000  ? 120 ILE A CA     1 
ATOM   1725 C C      . ILE A 1 120 ? 7.20600  -9.93800  2.22900   1.000 60.33000  ? 120 ILE A C      1 
ATOM   1726 O O      . ILE A 1 120 ? 7.01800  -8.77300  1.85800   1.000 49.91000  ? 120 ILE A O      1 
ATOM   1727 C CB     . ILE A 1 120 ? 7.97800  -10.02600 4.63100   1.000 52.07000  ? 120 ILE A CB     1 
ATOM   1728 C CG1    . ILE A 1 120 ? 8.28700  -8.55000  4.62900   1.000 51.78000  ? 120 ILE A CG1    1 
ATOM   1729 C CG2    . ILE A 1 120 ? 9.25400  -10.76100 4.27900   1.000 45.77000  ? 120 ILE A CG2    1 
ATOM   1730 C CD1    . ILE A 1 120 ? 9.38700  -8.19700  5.55700   1.000 50.31000  ? 120 ILE A CD1    1 
ATOM   1731 H H      . ILE A 1 120 ? 7.09500  -12.21000 4.27400   1.000 73.18000  ? 120 ILE A H      1 
ATOM   1732 H HA     . ILE A 1 120 ? 6.03800  -9.87900  3.86500   1.000 72.65000  ? 120 ILE A HA     1 
ATOM   1733 H HB     . ILE A 1 120 ? 7.66000  -10.29900 5.50600   1.000 62.86000  ? 120 ILE A HB     1 
ATOM   1734 H HG12   . ILE A 1 120 ? 8.55100  -8.28300  3.73500   1.000 62.52000  ? 120 ILE A HG12   1 
ATOM   1735 H HG13   . ILE A 1 120 ? 7.49500  -8.06100  4.90100   1.000 62.52000  ? 120 ILE A HG13   1 
ATOM   1736 H HG21   . ILE A 1 120 ? 9.88400  -10.66600 5.01100   1.000 55.31000  ? 120 ILE A HG21   1 
ATOM   1737 H HG22   . ILE A 1 120 ? 9.05000  -11.69800 4.13800   1.000 55.31000  ? 120 ILE A HG22   1 
ATOM   1738 H HG23   . ILE A 1 120 ? 9.62600  -10.37800 3.47000   1.000 55.31000  ? 120 ILE A HG23   1 
ATOM   1739 H HD11   . ILE A 1 120 ? 9.39400  -7.23500  5.68700   1.000 60.75000  ? 120 ILE A HD11   1 
ATOM   1740 H HD12   . ILE A 1 120 ? 9.24000  -8.64300  6.40600   1.000 60.75000  ? 120 ILE A HD12   1 
ATOM   1741 H HD13   . ILE A 1 120 ? 10.22900 -8.48500  5.17300   1.000 60.75000  ? 120 ILE A HD13   1 
ATOM   1742 N N      . GLY A 1 121 ? 7.78600  -10.82800 1.44500   1.000 48.81000  ? 121 GLY A N      1 
ATOM   1743 C CA     . GLY A 1 121 ? 8.15900  -10.44500 0.10800   1.000 51.66000  ? 121 GLY A CA     1 
ATOM   1744 C C      . GLY A 1 121 ? 6.97800  -10.31300 -0.82400  1.000 63.98000  ? 121 GLY A C      1 
ATOM   1745 O O      . GLY A 1 121 ? 7.07800  -9.61600  -1.83600  1.000 64.35000  ? 121 GLY A O      1 
ATOM   1746 H H      . GLY A 1 121 ? 7.96900  -11.64000 1.66300   1.000 58.95000  ? 121 GLY A H      1 
ATOM   1747 H HA2    . GLY A 1 121 ? 8.61800  -9.59100  0.13800   1.000 62.37000  ? 121 GLY A HA2    1 
ATOM   1748 H HA3    . GLY A 1 121 ? 8.76000  -11.11400 -0.25800  1.000 62.37000  ? 121 GLY A HA3    1 
ATOM   1749 N N      . GLN A 1 122 ? 5.86400  -10.98500 -0.52400  1.000 61.38000  ? 122 GLN A N      1 
ATOM   1750 C CA     . GLN A 1 122 ? 4.70600  -10.88000 -1.40400  1.000 56.00000  ? 122 GLN A CA     1 
ATOM   1751 C C      . GLN A 1 122 ? 4.15700  -9.46900  -1.35500  1.000 59.79000  ? 122 GLN A C      1 
ATOM   1752 O O      . GLN A 1 122 ? 3.43500  -9.05600  -2.26600  1.000 63.07000  ? 122 GLN A O      1 
ATOM   1753 C CB     . GLN A 1 122 ? 3.60300  -11.87500 -1.01700  1.000 83.99000  ? 122 GLN A CB     1 
ATOM   1754 C CG     . GLN A 1 122 ? 4.04600  -13.32300 -0.73200  1.000 77.39000  ? 122 GLN A CG     1 
ATOM   1755 C CD     . GLN A 1 122 ? 4.13200  -14.19600 -1.97400  1.000 84.40000  ? 122 GLN A CD     1 
ATOM   1756 O OE1    . GLN A 1 122 ? 3.14400  -14.81500 -2.40200  1.000 85.91000  ? 122 GLN A OE1    1 
ATOM   1757 N NE2    . GLN A 1 122 ? 5.33400  -14.26800 -2.55300  1.000 86.04000  ? 122 GLN A NE2    1 
ATOM   1758 H H      . GLN A 1 122 ? 5.75900  -11.49300 0.16200   1.000 74.04000  ? 122 GLN A H      1 
ATOM   1759 H HA     . GLN A 1 122 ? 4.97100  -11.11200 -2.30800  1.000 67.58000  ? 122 GLN A HA     1 
ATOM   1760 H HB2    . GLN A 1 122 ? 3.17100  -11.54700 -0.21300  1.000 101.17000 ? 122 GLN A HB2    1 
ATOM   1761 H HB3    . GLN A 1 122 ? 2.96300  -11.91200 -1.74500  1.000 101.17000 ? 122 GLN A HB3    1 
ATOM   1762 H HG2    . GLN A 1 122 ? 4.92500  -13.30500 -0.32300  1.000 93.25000  ? 122 GLN A HG2    1 
ATOM   1763 H HG3    . GLN A 1 122 ? 3.40600  -13.73100 -0.12800  1.000 93.25000  ? 122 GLN A HG3    1 
ATOM   1764 H HE21   . GLN A 1 122 ? 5.99800  -13.83600 -2.21900  1.000 103.63000 ? 122 GLN A HE21   1 
ATOM   1765 H HE22   . GLN A 1 122 ? 5.44300  -14.74800 -3.25800  1.000 103.63000 ? 122 GLN A HE22   1 
ATOM   1766 N N      . PHE A 1 123 ? 4.47300  -8.73400  -0.29200  1.000 42.98000  ? 123 PHE A N      1 
ATOM   1767 C CA     . PHE A 1 123 ? 4.11000  -7.33700  -0.17200  1.000 48.87000  ? 123 PHE A CA     1 
ATOM   1768 C C      . PHE A 1 123 ? 5.21400  -6.41200  -0.61900  1.000 48.88000  ? 123 PHE A C      1 
ATOM   1769 O O      . PHE A 1 123 ? 5.10700  -5.19600  -0.40700  1.000 52.01000  ? 123 PHE A O      1 
ATOM   1770 C CB     . PHE A 1 123 ? 3.73500  -7.03100  1.28500   1.000 54.98000  ? 123 PHE A CB     1 
ATOM   1771 C CG     . PHE A 1 123 ? 2.51300  -7.78500  1.75600   1.000 62.07000  ? 123 PHE A CG     1 
ATOM   1772 C CD1    . PHE A 1 123 ? 2.62500  -9.07800  2.23700   1.000 64.70000  ? 123 PHE A CD1    1 
ATOM   1773 C CD2    . PHE A 1 123 ? 1.26800  -7.20400  1.70300   1.000 67.14000  ? 123 PHE A CD2    1 
ATOM   1774 C CE1    . PHE A 1 123 ? 1.50900  -9.76600  2.68200   1.000 71.12000  ? 123 PHE A CE1    1 
ATOM   1775 C CE2    . PHE A 1 123 ? 0.15100  -7.87500  2.13200   1.000 61.45000  ? 123 PHE A CE2    1 
ATOM   1776 C CZ     . PHE A 1 123 ? 0.26900  -9.16700  2.63000   1.000 59.02000  ? 123 PHE A CZ     1 
ATOM   1777 H H      . PHE A 1 123 ? 4.90900  -9.03500  0.38600   1.000 51.95000  ? 123 PHE A H      1 
ATOM   1778 H HA     . PHE A 1 123 ? 3.33700  -7.16200  -0.73000  1.000 59.03000  ? 123 PHE A HA     1 
ATOM   1779 H HB2    . PHE A 1 123 ? 4.47800  -7.27800  1.85800   1.000 66.36000  ? 123 PHE A HB2    1 
ATOM   1780 H HB3    . PHE A 1 123 ? 3.55200  -6.08300  1.36900   1.000 66.36000  ? 123 PHE A HB3    1 
ATOM   1781 H HD1    . PHE A 1 123 ? 3.45900  -9.48900  2.26100   1.000 78.02000  ? 123 PHE A HD1    1 
ATOM   1782 H HD2    . PHE A 1 123 ? 1.18200  -6.34000  1.37100   1.000 80.94000  ? 123 PHE A HD2    1 
ATOM   1783 H HE1    . PHE A 1 123 ? 1.59700  -10.63000 3.01400   1.000 85.72000  ? 123 PHE A HE1    1 
ATOM   1784 H HE2    . PHE A 1 123 ? -0.68300 -7.46600  2.08900   1.000 74.12000  ? 123 PHE A HE2    1 
ATOM   1785 H HZ     . PHE A 1 123 ? -0.48400 -9.62500  2.92700   1.000 71.21000  ? 123 PHE A HZ     1 
ATOM   1786 N N      . GLY A 1 124 ? 6.29400  -6.96800  -1.17500  1.000 63.40000  ? 124 GLY A N      1 
ATOM   1787 C CA     . GLY A 1 124 ? 7.43300  -6.18400  -1.61300  1.000 67.81000  ? 124 GLY A CA     1 
ATOM   1788 C C      . GLY A 1 124 ? 8.04600  -5.25300  -0.58400  1.000 72.69000  ? 124 GLY A C      1 
ATOM   1789 O O      . GLY A 1 124 ? 8.31000  -4.08300  -0.86800  1.000 71.27000  ? 124 GLY A O      1 
ATOM   1790 H H      . GLY A 1 124 ? 6.38600  -7.81300  -1.30800  1.000 76.47000  ? 124 GLY A H      1 
ATOM   1791 H HA2    . GLY A 1 124 ? 8.13000  -6.79300  -1.90200  1.000 81.75000  ? 124 GLY A HA2    1 
ATOM   1792 H HA3    . GLY A 1 124 ? 7.15600  -5.63900  -2.36600  1.000 81.75000  ? 124 GLY A HA3    1 
ATOM   1793 N N      . VAL A 1 125 ? 8.24600  -5.74500  0.62600   1.000 58.11000  ? 125 VAL A N      1 
ATOM   1794 C CA     . VAL A 1 125 ? 9.05300  -5.02800  1.59400   1.000 38.91000  ? 125 VAL A CA     1 
ATOM   1795 C C      . VAL A 1 125 ? 10.05000 -5.99900  2.22800   1.000 34.07000  ? 125 VAL A C      1 
ATOM   1796 O O      . VAL A 1 125 ? 10.51200 -5.78300  3.35300   1.000 42.62000  ? 125 VAL A O      1 
ATOM   1797 C CB     . VAL A 1 125 ? 8.19400  -4.32500  2.64500   1.000 55.09000  ? 125 VAL A CB     1 
ATOM   1798 C CG1    . VAL A 1 125 ? 7.54200  -3.15300  1.98300   1.000 62.86000  ? 125 VAL A CG1    1 
ATOM   1799 C CG2    . VAL A 1 125 ? 7.16500  -5.24700  3.19300   1.000 56.78000  ? 125 VAL A CG2    1 
ATOM   1800 H H      . VAL A 1 125 ? 7.92600  -6.49100  0.91000   1.000 70.12000  ? 125 VAL A H      1 
ATOM   1801 H HA     . VAL A 1 125 ? 9.55700  -4.33900  1.13300   1.000 47.07000  ? 125 VAL A HA     1 
ATOM   1802 H HB     . VAL A 1 125 ? 8.74100  -4.03300  3.39100   1.000 66.48000  ? 125 VAL A HB     1 
ATOM   1803 H HG11   . VAL A 1 125 ? 6.99500  -2.68600  2.63500   1.000 75.81000  ? 125 VAL A HG11   1 
ATOM   1804 H HG12   . VAL A 1 125 ? 8.23000  -2.55900  1.64300   1.000 75.81000  ? 125 VAL A HG12   1 
ATOM   1805 H HG13   . VAL A 1 125 ? 6.98800  -3.47000  1.25300   1.000 75.81000  ? 125 VAL A HG13   1 
ATOM   1806 H HG21   . VAL A 1 125 ? 6.64700  -4.77900  3.86700   1.000 68.52000  ? 125 VAL A HG21   1 
ATOM   1807 H HG22   . VAL A 1 125 ? 6.58400  -5.53700  2.47200   1.000 68.52000  ? 125 VAL A HG22   1 
ATOM   1808 H HG23   . VAL A 1 125 ? 7.60700  -6.01400  3.59000   1.000 68.52000  ? 125 VAL A HG23   1 
ATOM   1809 N N      . GLY A 1 126 ? 10.46000 -7.02400  1.46000   1.000 30.89000  ? 126 GLY A N      1 
ATOM   1810 C CA     . GLY A 1 126 ? 11.35800 -8.06500  1.96900   1.000 40.16000  ? 126 GLY A CA     1 
ATOM   1811 C C      . GLY A 1 126 ? 12.74100 -7.57800  2.37800   1.000 36.89000  ? 126 GLY A C      1 
ATOM   1812 O O      . GLY A 1 126 ? 13.45800 -8.28000  3.10300   1.000 50.78000  ? 126 GLY A O      1 
ATOM   1813 H H      . GLY A 1 126 ? 10.23000 -7.13700  0.64000   1.000 37.45000  ? 126 GLY A H      1 
ATOM   1814 H HA2    . GLY A 1 126 ? 10.94800 -8.47600  2.74600   1.000 48.58000  ? 126 GLY A HA2    1 
ATOM   1815 H HA3    . GLY A 1 126 ? 11.47400 -8.73800  1.28000   1.000 48.58000  ? 126 GLY A HA3    1 
ATOM   1816 N N      . PHE A 1 127 ? 13.14500 -6.41300  1.90500   1.000 39.59000  ? 127 PHE A N      1 
ATOM   1817 C CA     . PHE A 1 127 ? 14.42800 -5.86300  2.30400   1.000 37.71000  ? 127 PHE A CA     1 
ATOM   1818 C C      . PHE A 1 127 ? 14.53800 -5.79800  3.81000   1.000 49.14000  ? 127 PHE A C      1 
ATOM   1819 O O      . PHE A 1 127 ? 15.54600 -6.22100  4.39300   1.000 37.09000  ? 127 PHE A O      1 
ATOM   1820 C CB     . PHE A 1 127 ? 14.56800 -4.48200  1.67500   1.000 35.57000  ? 127 PHE A CB     1 
ATOM   1821 C CG     . PHE A 1 127 ? 15.66500 -3.63700  2.23300   1.000 47.34000  ? 127 PHE A CG     1 
ATOM   1822 C CD1    . PHE A 1 127 ? 16.97000 -3.74500  1.75700   1.000 34.79000  ? 127 PHE A CD1    1 
ATOM   1823 C CD2    . PHE A 1 127 ? 15.37700 -2.66800  3.15700   1.000 40.72000  ? 127 PHE A CD2    1 
ATOM   1824 C CE1    . PHE A 1 127 ? 17.97500 -2.90200  2.21700   1.000 32.64000  ? 127 PHE A CE1    1 
ATOM   1825 C CE2    . PHE A 1 127 ? 16.39100 -1.82800  3.63000   1.000 50.06000  ? 127 PHE A CE2    1 
ATOM   1826 C CZ     . PHE A 1 127 ? 17.68700 -1.95200  3.14000   1.000 33.96000  ? 127 PHE A CZ     1 
ATOM   1827 H H      . PHE A 1 127 ? 12.70000 -5.92300  1.35600   1.000 47.90000  ? 127 PHE A H      1 
ATOM   1828 H HA     . PHE A 1 127 ? 15.15300 -6.42400  1.98700   1.000 45.64000  ? 127 PHE A HA     1 
ATOM   1829 H HB2    . PHE A 1 127 ? 14.74100 -4.59400  0.72700   1.000 43.06000  ? 127 PHE A HB2    1 
ATOM   1830 H HB3    . PHE A 1 127 ? 13.73600 -4.00100  1.80600   1.000 43.06000  ? 127 PHE A HB3    1 
ATOM   1831 H HD1    . PHE A 1 127 ? 17.17200 -4.39300  1.12100   1.000 42.13000  ? 127 PHE A HD1    1 
ATOM   1832 H HD2    . PHE A 1 127 ? 14.50700 -2.56800  3.47000   1.000 49.24000  ? 127 PHE A HD2    1 
ATOM   1833 H HE1    . PHE A 1 127 ? 18.84200 -2.98900  1.89300   1.000 39.55000  ? 127 PHE A HE1    1 
ATOM   1834 H HE2    . PHE A 1 127 ? 16.19800 -1.18500  4.27300   1.000 60.46000  ? 127 PHE A HE2    1 
ATOM   1835 H HZ     . PHE A 1 127 ? 18.35600 -1.38300  3.44600   1.000 41.13000  ? 127 PHE A HZ     1 
ATOM   1836 N N      . TYR A 1 128 ? 13.48900 -5.28600  4.45000   1.000 36.60000  ? 128 TYR A N      1 
ATOM   1837 C CA     . TYR A 1 128 ? 13.44500 -5.12600  5.88300   1.000 43.95000  ? 128 TYR A CA     1 
ATOM   1838 C C      . TYR A 1 128 ? 13.43300 -6.44500  6.64400   1.000 43.54000  ? 128 TYR A C      1 
ATOM   1839 O O      . TYR A 1 128 ? 13.64200 -6.41700  7.85000   1.000 34.35000  ? 128 TYR A O      1 
ATOM   1840 C CB     . TYR A 1 128 ? 12.22700 -4.27900  6.20800   1.000 33.65000  ? 128 TYR A CB     1 
ATOM   1841 C CG     . TYR A 1 128 ? 12.28800 -2.93100  5.53100   1.000 33.70000  ? 128 TYR A CG     1 
ATOM   1842 C CD1    . TYR A 1 128 ? 13.09800 -1.89400  6.03800   1.000 40.36000  ? 128 TYR A CD1    1 
ATOM   1843 C CD2    . TYR A 1 128 ? 11.55800 -2.69000  4.37900   1.000 45.85000  ? 128 TYR A CD2    1 
ATOM   1844 C CE1    . TYR A 1 128 ? 13.16700 -0.65300  5.38800   1.000 44.24000  ? 128 TYR A CE1    1 
ATOM   1845 C CE2    . TYR A 1 128 ? 11.60600 -1.46300  3.73200   1.000 45.01000  ? 128 TYR A CE2    1 
ATOM   1846 C CZ     . TYR A 1 128 ? 12.40700 -0.45100  4.22600   1.000 48.30000  ? 128 TYR A CZ     1 
ATOM   1847 O OH     . TYR A 1 128 ? 12.43200 0.75900   3.56500   1.000 52.51000  ? 128 TYR A OH     1 
ATOM   1848 H H      . TYR A 1 128 ? 12.77200 -5.01900  4.05700   1.000 44.30000  ? 128 TYR A H      1 
ATOM   1849 H HA     . TYR A 1 128 ? 14.23900 -4.66400  6.19600   1.000 53.12000  ? 128 TYR A HA     1 
ATOM   1850 H HB2    . TYR A 1 128 ? 11.42800 -4.73800  5.90400   1.000 40.76000  ? 128 TYR A HB2    1 
ATOM   1851 H HB3    . TYR A 1 128 ? 12.18300 -4.13700  7.16700   1.000 40.76000  ? 128 TYR A HB3    1 
ATOM   1852 H HD1    . TYR A 1 128 ? 13.59300 -2.03400  6.81300   1.000 48.82000  ? 128 TYR A HD1    1 
ATOM   1853 H HD2    . TYR A 1 128 ? 11.02400 -3.36600  4.03000   1.000 55.40000  ? 128 TYR A HD2    1 
ATOM   1854 H HE1    . TYR A 1 128 ? 13.70700 0.02500   5.72300   1.000 53.47000  ? 128 TYR A HE1    1 
ATOM   1855 H HE2    . TYR A 1 128 ? 11.09800 -1.32200  2.96600   1.000 54.39000  ? 128 TYR A HE2    1 
ATOM   1856 H HH     . TYR A 1 128 ? 12.91500 1.30400   3.98300   1.000 63.39000  ? 128 TYR A HH     1 
ATOM   1857 N N      . SER A 1 129 ? 13.25500 -7.58800  5.98400   1.000 28.30000  ? 129 SER A N      1 
ATOM   1858 C CA     . SER A 1 129 ? 13.50500 -8.84500  6.66000   1.000 29.00000  ? 129 SER A CA     1 
ATOM   1859 C C      . SER A 1 129 ? 14.92000 -8.94500  7.21100   1.000 47.71000  ? 129 SER A C      1 
ATOM   1860 O O      . SER A 1 129 ? 15.18700 -9.83400  8.01400   1.000 42.33000  ? 129 SER A O      1 
ATOM   1861 C CB     . SER A 1 129 ? 13.22700 -9.98300  5.68000   1.000 31.23000  ? 129 SER A CB     1 
ATOM   1862 O OG     . SER A 1 129 ? 14.21100 -10.12400 4.71900   1.000 44.06000  ? 129 SER A OG     1 
ATOM   1863 H H      . SER A 1 129 ? 12.99700 -7.65500  5.16700   1.000 34.34000  ? 129 SER A H      1 
ATOM   1864 H HA     . SER A 1 129 ? 12.90600 -8.93700  7.41700   1.000 35.18000  ? 129 SER A HA     1 
ATOM   1865 H HB2    . SER A 1 129 ? 13.16700 -10.81200 6.18100   1.000 37.85000  ? 129 SER A HB2    1 
ATOM   1866 H HB3    . SER A 1 129 ? 12.38500 -9.80400  5.23300   1.000 37.85000  ? 129 SER A HB3    1 
ATOM   1867 H HG     . SER A 1 129 ? 14.03400 -9.64300  4.05400   1.000 53.25000  ? 129 SER A HG     1 
ATOM   1868 N N      . LEU A 1 130 ? 15.84800 -8.08800  6.78300   1.000 33.67000  ? 130 LEU A N      1 
ATOM   1869 C CA     . LEU A 1 130 ? 17.20700 -8.21800  7.26200   1.000 41.72000  ? 130 LEU A CA     1 
ATOM   1870 C C      . LEU A 1 130 ? 17.29100 -8.01900  8.76000   1.000 44.56000  ? 130 LEU A C      1 
ATOM   1871 O O      . LEU A 1 130 ? 18.24200 -8.48800  9.37600   1.000 42.02000  ? 130 LEU A O      1 
ATOM   1872 C CB     . LEU A 1 130 ? 18.10900 -7.22900  6.50800   1.000 35.45000  ? 130 LEU A CB     1 
ATOM   1873 C CG     . LEU A 1 130 ? 17.93800 -5.75700  6.84000   1.000 42.86000  ? 130 LEU A CG     1 
ATOM   1874 C CD1    . LEU A 1 130 ? 18.71700 -5.35500  8.06200   1.000 43.44000  ? 130 LEU A CD1    1 
ATOM   1875 C CD2    . LEU A 1 130 ? 18.31800 -4.92300  5.64300   1.000 37.89000  ? 130 LEU A CD2    1 
ATOM   1876 H H      . LEU A 1 130 ? 15.71300 -7.44300  6.23100   1.000 40.78000  ? 130 LEU A H      1 
ATOM   1877 H HA     . LEU A 1 130 ? 17.54300 -9.10900  7.07600   1.000 50.44000  ? 130 LEU A HA     1 
ATOM   1878 H HB2    . LEU A 1 130 ? 19.03100 -7.45800  6.70100   1.000 42.92000  ? 130 LEU A HB2    1 
ATOM   1879 H HB3    . LEU A 1 130 ? 17.93400 -7.32800  5.55900   1.000 42.92000  ? 130 LEU A HB3    1 
ATOM   1880 H HG     . LEU A 1 130 ? 17.00600 -5.59100  7.05300   1.000 51.81000  ? 130 LEU A HG     1 
ATOM   1881 H HD11   . LEU A 1 130 ? 18.62500 -4.39800  8.19400   1.000 52.51000  ? 130 LEU A HD11   1 
ATOM   1882 H HD12   . LEU A 1 130 ? 18.36600 -5.83000  8.83100   1.000 52.51000  ? 130 LEU A HD12   1 
ATOM   1883 H HD13   . LEU A 1 130 ? 19.65100 -5.58200  7.93000   1.000 52.51000  ? 130 LEU A HD13   1 
ATOM   1884 H HD21   . LEU A 1 130 ? 18.19800 -3.98500  5.86000   1.000 45.85000  ? 130 LEU A HD21   1 
ATOM   1885 H HD22   . LEU A 1 130 ? 19.24600 -5.09400  5.42000   1.000 45.85000  ? 130 LEU A HD22   1 
ATOM   1886 H HD23   . LEU A 1 130 ? 17.74900 -5.16400  4.89600   1.000 45.85000  ? 130 LEU A HD23   1 
ATOM   1887 N N      . PHE A 1 131 ? 16.34500 -7.32700  9.34600   1.000 32.29000  ? 131 PHE A N      1 
ATOM   1888 C CA     . PHE A 1 131 ? 16.38600 -7.02900  10.76500  1.000 49.71000  ? 131 PHE A CA     1 
ATOM   1889 C C      . PHE A 1 131 ? 15.97300 -8.21200  11.64500  1.000 50.78000  ? 131 PHE A C      1 
ATOM   1890 O O      . PHE A 1 131 ? 16.07500 -8.13500  12.87700  1.000 40.89000  ? 131 PHE A O      1 
ATOM   1891 C CB     . PHE A 1 131 ? 15.50000 -5.82900  11.05800  1.000 45.24000  ? 131 PHE A CB     1 
ATOM   1892 C CG     . PHE A 1 131 ? 16.02200 -4.53800  10.49100  1.000 37.50000  ? 131 PHE A CG     1 
ATOM   1893 C CD1    . PHE A 1 131 ? 17.02700 -3.87300  11.10100  1.000 40.02000  ? 131 PHE A CD1    1 
ATOM   1894 C CD2    . PHE A 1 131 ? 15.45900 -3.97700  9.37400   1.000 50.42000  ? 131 PHE A CD2    1 
ATOM   1895 C CE1    . PHE A 1 131 ? 17.49700 -2.68900  10.59400  1.000 49.29000  ? 131 PHE A CE1    1 
ATOM   1896 C CE2    . PHE A 1 131 ? 15.90200 -2.77900  8.89100   1.000 32.20000  ? 131 PHE A CE2    1 
ATOM   1897 C CZ     . PHE A 1 131 ? 16.92500 -2.14200  9.48400   1.000 38.24000  ? 131 PHE A CZ     1 
ATOM   1898 H H      . PHE A 1 131 ? 15.65500 -7.01000  8.94100   1.000 39.13000  ? 131 PHE A H      1 
ATOM   1899 H HA     . PHE A 1 131 ? 17.29600 -6.79900  11.01100  1.000 60.03000  ? 131 PHE A HA     1 
ATOM   1900 H HB2    . PHE A 1 131 ? 14.62400 -5.98800  10.67500  1.000 54.67000  ? 131 PHE A HB2    1 
ATOM   1901 H HB3    . PHE A 1 131 ? 15.42800 -5.72300  12.01900  1.000 54.67000  ? 131 PHE A HB3    1 
ATOM   1902 H HD1    . PHE A 1 131 ? 17.40600 -4.22300  11.87500  1.000 48.41000  ? 131 PHE A HD1    1 
ATOM   1903 H HD2    . PHE A 1 131 ? 14.76600 -4.41900  8.93800   1.000 60.88000  ? 131 PHE A HD2    1 
ATOM   1904 H HE1    . PHE A 1 131 ? 18.20900 -2.25800  11.00800  1.000 59.53000  ? 131 PHE A HE1    1 
ATOM   1905 H HE2    . PHE A 1 131 ? 15.49300 -2.40200  8.14700   1.000 39.02000  ? 131 PHE A HE2    1 
ATOM   1906 H HZ     . PHE A 1 131 ? 17.24000 -1.33700  9.14100   1.000 46.27000  ? 131 PHE A HZ     1 
ATOM   1907 N N      . LEU A 1 132 ? 15.51000 -9.29800  11.04900  1.000 40.78000  ? 132 LEU A N      1 
ATOM   1908 C CA     . LEU A 1 132 ? 15.42700 -10.53500 11.78300  1.000 46.71000  ? 132 LEU A CA     1 
ATOM   1909 C C      . LEU A 1 132 ? 16.78100 -10.90600 12.36400  1.000 39.38000  ? 132 LEU A C      1 
ATOM   1910 O O      . LEU A 1 132 ? 16.86200 -11.43600 13.47600  1.000 40.61000  ? 132 LEU A O      1 
ATOM   1911 C CB     . LEU A 1 132 ? 14.93500 -11.63600 10.86000  1.000 41.59000  ? 132 LEU A CB     1 
ATOM   1912 C CG     . LEU A 1 132 ? 13.50800 -11.53700 10.31000  1.000 48.45000  ? 132 LEU A CG     1 
ATOM   1913 C CD1    . LEU A 1 132 ? 13.29700 -12.56000 9.17100   1.000 50.91000  ? 132 LEU A CD1    1 
ATOM   1914 C CD2    . LEU A 1 132 ? 12.52000 -11.76900 11.44400  1.000 58.20000  ? 132 LEU A CD2    1 
ATOM   1915 H H      . LEU A 1 132 ? 15.24300 -9.34100  10.23300  1.000 49.32000  ? 132 LEU A H      1 
ATOM   1916 H HA     . LEU A 1 132 ? 14.79500 -10.43600 12.51200  1.000 56.44000  ? 132 LEU A HA     1 
ATOM   1917 H HB2    . LEU A 1 132 ? 15.52800 -11.66300 10.09300  1.000 50.30000  ? 132 LEU A HB2    1 
ATOM   1918 H HB3    . LEU A 1 132 ? 14.98700 -12.47300 11.34800  1.000 50.30000  ? 132 LEU A HB3    1 
ATOM   1919 H HG     . LEU A 1 132 ? 13.35300 -10.65400 9.93800   1.000 58.52000  ? 132 LEU A HG     1 
ATOM   1920 H HD11   . LEU A 1 132 ? 12.39000 -12.47800 8.83700   1.000 61.48000  ? 132 LEU A HD11   1 
ATOM   1921 H HD12   . LEU A 1 132 ? 13.93000 -12.37500 8.46000   1.000 61.48000  ? 132 LEU A HD12   1 
ATOM   1922 H HD13   . LEU A 1 132 ? 13.44200 -13.45400 9.52000   1.000 61.48000  ? 132 LEU A HD13   1 
ATOM   1923 H HD21   . LEU A 1 132 ? 11.61900 -11.76300 11.08400  1.000 70.23000  ? 132 LEU A HD21   1 
ATOM   1924 H HD22   . LEU A 1 132 ? 12.70600 -12.62900 11.85300  1.000 70.23000  ? 132 LEU A HD22   1 
ATOM   1925 H HD23   . LEU A 1 132 ? 12.61900 -11.06200 12.09900  1.000 70.23000  ? 132 LEU A HD23   1 
ATOM   1926 N N      . VAL A 1 133 ? 17.85900 -10.67100 11.61500  1.000 43.86000  ? 133 VAL A N      1 
ATOM   1927 C CA     . VAL A 1 133 ? 19.18700 -11.14200 12.00400  1.000 38.34000  ? 133 VAL A CA     1 
ATOM   1928 C C      . VAL A 1 133 ? 20.15700 -10.00000 12.27200  1.000 40.01000  ? 133 VAL A C      1 
ATOM   1929 O O      . VAL A 1 133 ? 21.28000 -10.24900 12.72000  1.000 39.89000  ? 133 VAL A O      1 
ATOM   1930 C CB     . VAL A 1 133 ? 19.78600 -12.11900 10.96700  1.000 53.21000  ? 133 VAL A CB     1 
ATOM   1931 C CG1    . VAL A 1 133 ? 18.86900 -13.34400 10.78100  1.000 45.50000  ? 133 VAL A CG1    1 
ATOM   1932 C CG2    . VAL A 1 133 ? 20.07600 -11.43300 9.59000   1.000 53.13000  ? 133 VAL A CG2    1 
ATOM   1933 H H      . VAL A 1 133 ? 17.84600 -10.23700 10.87300  1.000 53.01000  ? 133 VAL A H      1 
ATOM   1934 H HA     . VAL A 1 133 ? 19.08800 -11.63700 12.83200  1.000 46.39000  ? 133 VAL A HA     1 
ATOM   1935 H HB     . VAL A 1 133 ? 20.64100 -12.41900 11.31400  1.000 64.23000  ? 133 VAL A HB     1 
ATOM   1936 H HG11   . VAL A 1 133 ? 19.31000 -13.98300 10.20000  1.000 54.98000  ? 133 VAL A HG11   1 
ATOM   1937 H HG12   . VAL A 1 133 ? 18.69900 -13.74600 11.64700  1.000 54.98000  ? 133 VAL A HG12   1 
ATOM   1938 H HG13   . VAL A 1 133 ? 18.03300 -13.05500 10.38100  1.000 54.98000  ? 133 VAL A HG13   1 
ATOM   1939 H HG21   . VAL A 1 133 ? 20.47900 -12.08100 8.99300   1.000 64.13000  ? 133 VAL A HG21   1 
ATOM   1940 H HG22   . VAL A 1 133 ? 19.24100 -11.11100 9.21500   1.000 64.13000  ? 133 VAL A HG22   1 
ATOM   1941 H HG23   . VAL A 1 133 ? 20.68400 -10.68900 9.73000   1.000 64.13000  ? 133 VAL A HG23   1 
ATOM   1942 N N      . ALA A 1 134 ? 19.74300 -8.75500  12.10200  1.000 43.96000  ? 134 ALA A N      1 
ATOM   1943 C CA     . ALA A 1 134 ? 20.67200 -7.65800  12.28000  1.000 44.14000  ? 134 ALA A CA     1 
ATOM   1944 C C      . ALA A 1 134 ? 19.99300 -6.48100  12.93900  1.000 39.15000  ? 134 ALA A C      1 
ATOM   1945 O O      . ALA A 1 134 ? 18.79900 -6.26700  12.78600  1.000 45.81000  ? 134 ALA A O      1 
ATOM   1946 C CB     . ALA A 1 134 ? 21.25200 -7.23500  10.91700  1.000 39.20000  ? 134 ALA A CB     1 
ATOM   1947 H H      . ALA A 1 134 ? 18.94300 -8.52700  11.88700  1.000 53.13000  ? 134 ALA A H      1 
ATOM   1948 H HA     . ALA A 1 134 ? 21.38900 -7.93100  12.87400  1.000 53.34000  ? 134 ALA A HA     1 
ATOM   1949 H HB1    . ALA A 1 134 ? 21.90000 -6.52700  11.05500  1.000 47.42000  ? 134 ALA A HB1    1 
ATOM   1950 H HB2    . ALA A 1 134 ? 21.68200 -8.00100  10.50500  1.000 47.42000  ? 134 ALA A HB2    1 
ATOM   1951 H HB3    . ALA A 1 134 ? 20.53100 -6.91700  10.35200  1.000 47.42000  ? 134 ALA A HB3    1 
ATOM   1952 N N      . ASP A 1 135 ? 20.78500 -5.67400  13.61600  1.000 48.85000  ? 135 ASP A N      1 
ATOM   1953 C CA     . ASP A 1 135 ? 20.27900 -4.47500  14.26300  1.000 54.09000  ? 135 ASP A CA     1 
ATOM   1954 C C      . ASP A 1 135 ? 20.79800 -3.18800  13.63700  1.000 51.76000  ? 135 ASP A C      1 
ATOM   1955 O O      . ASP A 1 135 ? 20.31400 -2.11100  13.97800  1.000 65.46000  ? 135 ASP A O      1 
ATOM   1956 C CB     . ASP A 1 135 ? 20.66200 -4.48800  15.74600  1.000 63.84000  ? 135 ASP A CB     1 
ATOM   1957 C CG     . ASP A 1 135 ? 22.16600 -4.61800  15.95600  1.000 66.23000  ? 135 ASP A CG     1 
ATOM   1958 O OD1    . ASP A 1 135 ? 22.91000 -3.75300  15.44400  1.000 74.64000  ? 135 ASP A OD1    1 
ATOM   1959 O OD2    . ASP A 1 135 ? 22.61400 -5.62300  16.53700  1.000 69.83000  ? 135 ASP A OD2    1 
ATOM   1960 H H      . ASP A 1 135 ? 21.63000 -5.79800  13.71700  1.000 59.00000  ? 135 ASP A H      1 
ATOM   1961 H HA     . ASP A 1 135 ? 19.31100 -4.46900  14.19700  1.000 65.28000  ? 135 ASP A HA     1 
ATOM   1962 H HB2    . ASP A 1 135 ? 20.37200 -3.65800  16.15600  1.000 76.98000  ? 135 ASP A HB2    1 
ATOM   1963 H HB3    . ASP A 1 135 ? 20.23100 -5.24100  16.17800  1.000 76.98000  ? 135 ASP A HB3    1 
ATOM   1964 N N      . HIS A 1 136 ? 21.78700 -3.29800  12.76000  1.000 48.37000  ? 136 HIS A N      1 
ATOM   1965 C CA     . HIS A 1 136 ? 22.36800 -2.14000  12.04900  1.000 49.13000  ? 136 HIS A CA     1 
ATOM   1966 C C      . HIS A 1 136 ? 22.59200 -2.61500  10.62200  1.000 44.32000  ? 136 HIS A C      1 
ATOM   1967 O O      . HIS A 1 136 ? 22.74300 -3.81400  10.44700  1.000 41.29000  ? 136 HIS A O      1 
ATOM   1968 C CB     . HIS A 1 136 ? 23.63600 -1.65200  12.74500  1.000 44.87000  ? 136 HIS A CB     1 
ATOM   1969 C CG     . HIS A 1 136 ? 23.91500 -0.21700  12.52900  1.000 62.62000  ? 136 HIS A CG     1 
ATOM   1970 N ND1    . HIS A 1 136 ? 23.46800 0.75400   13.39400  1.000 55.10000  ? 136 HIS A ND1    1 
ATOM   1971 C CD2    . HIS A 1 136 ? 24.57900 0.41100   11.56500  1.000 86.59000  ? 136 HIS A CD2    1 
ATOM   1972 C CE1    . HIS A 1 136 ? 23.86300 1.93400   12.95300  1.000 73.73000  ? 136 HIS A CE1    1 
ATOM   1973 N NE2    . HIS A 1 136 ? 24.53400 1.74800   11.84500  1.000 80.83000  ? 136 HIS A NE2    1 
ATOM   1974 H H      . HIS A 1 136 ? 22.17300 -4.08500  12.54200  1.000 58.42000  ? 136 HIS A H      1 
ATOM   1975 H HA     . HIS A 1 136 ? 21.71200 -1.40200  12.02600  1.000 59.34000  ? 136 HIS A HA     1 
ATOM   1976 H HB2    . HIS A 1 136 ? 23.54900 -1.81800  13.70700  1.000 54.22000  ? 136 HIS A HB2    1 
ATOM   1977 H HB3    . HIS A 1 136 ? 24.39500 -2.17500  12.41400  1.000 54.22000  ? 136 HIS A HB3    1 
ATOM   1978 H HD2    . HIS A 1 136 ? 24.99800 0.01700   10.82600  1.000 104.29000 ? 136 HIS A HD2    1 
ATOM   1979 H HE1    . HIS A 1 136 ? 23.68700 2.76400   13.36100  1.000 88.86000  ? 136 HIS A HE1    1 
ATOM   1980 H HE2    . HIS A 1 136 ? 24.89500 2.38000   11.36900  1.000 97.38000  ? 136 HIS A HE2    1 
ATOM   1981 N N      . VAL A 1 137 ? 22.49000 -1.72100  9.64700   1.000 48.04000  ? 137 VAL A N      1 
ATOM   1982 C CA     . VAL A 1 137 ? 22.73600 -2.08600  8.25400   1.000 40.82000  ? 137 VAL A CA     1 
ATOM   1983 C C      . VAL A 1 137 ? 23.26300 -0.90000  7.46300   1.000 33.64000  ? 137 VAL A C      1 
ATOM   1984 O O      . VAL A 1 137 ? 22.79400 0.22200   7.63600   1.000 37.71000  ? 137 VAL A O      1 
ATOM   1985 C CB     . VAL A 1 137 ? 21.48400 -2.56900  7.52800   1.000 38.41000  ? 137 VAL A CB     1 
ATOM   1986 C CG1    . VAL A 1 137 ? 20.41500 -1.50100  7.52900   1.000 38.78000  ? 137 VAL A CG1    1 
ATOM   1987 C CG2    . VAL A 1 137 ? 21.87600 -2.89700  6.07200   1.000 37.98000  ? 137 VAL A CG2    1 
ATOM   1988 H H      . VAL A 1 137 ? 22.26700 -0.89900  9.76800   1.000 58.02000  ? 137 VAL A H      1 
ATOM   1989 H HA     . VAL A 1 137 ? 23.40500 -2.78600  8.30300   1.000 49.37000  ? 137 VAL A HA     1 
ATOM   1990 H HB     . VAL A 1 137 ? 21.12500 -3.35200  7.97300   1.000 46.48000  ? 137 VAL A HB     1 
ATOM   1991 H HG11   . VAL A 1 137 ? 19.54800 -1.92200  7.42000   1.000 46.91000  ? 137 VAL A HG11   1 
ATOM   1992 H HG12   . VAL A 1 137 ? 20.44700 -1.02400  8.37300   1.000 46.91000  ? 137 VAL A HG12   1 
ATOM   1993 H HG13   . VAL A 1 137 ? 20.58000 -0.88800  6.79600   1.000 46.91000  ? 137 VAL A HG13   1 
ATOM   1994 H HG21   . VAL A 1 137 ? 21.26800 -3.56900  5.72500   1.000 45.96000  ? 137 VAL A HG21   1 
ATOM   1995 H HG22   . VAL A 1 137 ? 21.81400 -2.08900  5.53800   1.000 45.96000  ? 137 VAL A HG22   1 
ATOM   1996 H HG23   . VAL A 1 137 ? 22.78500 -3.23400  6.05800   1.000 45.96000  ? 137 VAL A HG23   1 
ATOM   1997 N N      . GLN A 1 138 ? 24.24900 -1.15000  6.60000   1.000 33.60000  ? 138 GLN A N      1 
ATOM   1998 C CA     . GLN A 1 138 ? 24.73000 -0.17000  5.64100   1.000 38.17000  ? 138 GLN A CA     1 
ATOM   1999 C C      . GLN A 1 138 ? 24.41500 -0.70900  4.26100   1.000 36.08000  ? 138 GLN A C      1 
ATOM   2000 O O      . GLN A 1 138 ? 24.58400 -1.92100  3.99900   1.000 24.43000  ? 138 GLN A O      1 
ATOM   2001 C CB     . GLN A 1 138 ? 26.22900 0.06500   5.79100   1.000 34.87000  ? 138 GLN A CB     1 
ATOM   2002 C CG     . GLN A 1 138 ? 26.62300 0.62300   7.15100   1.000 46.44000  ? 138 GLN A CG     1 
ATOM   2003 C CD     . GLN A 1 138 ? 28.13300 0.79500   7.30700   1.000 38.78000  ? 138 GLN A CD     1 
ATOM   2004 O OE1    . GLN A 1 138 ? 28.92900 0.25000   6.51500   1.000 40.01000  ? 138 GLN A OE1    1 
ATOM   2005 N NE2    . GLN A 1 138 ? 28.53000 1.54600   8.34100   1.000 49.34000  ? 138 GLN A NE2    1 
ATOM   2006 H H      . GLN A 1 138 ? 24.66300 -1.90300  6.55500   1.000 40.70000  ? 138 GLN A H      1 
ATOM   2007 H HA     . GLN A 1 138 ? 24.29800 0.68900   5.76900   1.000 46.19000  ? 138 GLN A HA     1 
ATOM   2008 H HB2    . GLN A 1 138 ? 26.69100 -0.77900  5.67000   1.000 42.23000  ? 138 GLN A HB2    1 
ATOM   2009 H HB3    . GLN A 1 138 ? 26.51500 0.70000   5.11500   1.000 42.23000  ? 138 GLN A HB3    1 
ATOM   2010 H HG2    . GLN A 1 138 ? 26.20900 1.49200   7.26800   1.000 56.11000  ? 138 GLN A HG2    1 
ATOM   2011 H HG3    . GLN A 1 138 ? 26.31700 0.01400   7.84200   1.000 56.11000  ? 138 GLN A HG3    1 
ATOM   2012 H HE21   . GLN A 1 138 ? 27.94600 1.89700   8.86700   1.000 59.59000  ? 138 GLN A HE21   1 
ATOM   2013 H HE22   . GLN A 1 138 ? 29.36800 1.67900   8.48000   1.000 59.59000  ? 138 GLN A HE22   1 
ATOM   2014 N N      . VAL A 1 139 ? 24.01000 0.20100   3.37500   1.000 31.75000  ? 139 VAL A N      1 
ATOM   2015 C CA     . VAL A 1 139 ? 23.76000 -0.12400  1.97300   1.000 32.83000  ? 139 VAL A CA     1 
ATOM   2016 C C      . VAL A 1 139 ? 24.65500 0.74500   1.11400   1.000 35.54000  ? 139 VAL A C      1 
ATOM   2017 O O      . VAL A 1 139 ? 24.52500 1.97000   1.12200   1.000 31.12000  ? 139 VAL A O      1 
ATOM   2018 C CB     . VAL A 1 139 ? 22.28400 0.08000   1.58300   1.000 30.86000  ? 139 VAL A CB     1 
ATOM   2019 C CG1    . VAL A 1 139 ? 22.07100 -0.34400  0.10500   1.000 33.10000  ? 139 VAL A CG1    1 
ATOM   2020 C CG2    . VAL A 1 139 ? 21.37400 -0.72800  2.46600   1.000 35.76000  ? 139 VAL A CG2    1 
ATOM   2021 H H      . VAL A 1 139 ? 23.87100 1.02700   3.56800   1.000 38.49000  ? 139 VAL A H      1 
ATOM   2022 H HA     . VAL A 1 139 ? 23.99600 -1.05300  1.82400   1.000 39.77000  ? 139 VAL A HA     1 
ATOM   2023 H HB     . VAL A 1 139 ? 22.06300 1.01800   1.69300   1.000 37.41000  ? 139 VAL A HB     1 
ATOM   2024 H HG11   . VAL A 1 139 ? 21.12000 -0.36500  -0.08400  1.000 40.11000  ? 139 VAL A HG11   1 
ATOM   2025 H HG12   . VAL A 1 139 ? 22.50800 0.30000   -0.47400  1.000 40.11000  ? 139 VAL A HG12   1 
ATOM   2026 H HG13   . VAL A 1 139 ? 22.45500 -1.22400  -0.03000  1.000 40.11000  ? 139 VAL A HG13   1 
ATOM   2027 H HG21   . VAL A 1 139 ? 20.45200 -0.51700  2.24800   1.000 43.29000  ? 139 VAL A HG21   1 
ATOM   2028 H HG22   . VAL A 1 139 ? 21.54200 -1.67100  2.31300   1.000 43.29000  ? 139 VAL A HG22   1 
ATOM   2029 H HG23   . VAL A 1 139 ? 21.55300 -0.50600  3.39300   1.000 43.29000  ? 139 VAL A HG23   1 
ATOM   2030 N N      . ILE A 1 140 ? 25.51900 0.11400   0.34700   1.000 25.30000  ? 140 ILE A N      1 
ATOM   2031 C CA     . ILE A 1 140 ? 26.46700 0.78100   -0.52600  1.000 31.74000  ? 140 ILE A CA     1 
ATOM   2032 C C      . ILE A 1 140 ? 26.05600 0.55500   -1.97400  1.000 30.73000  ? 140 ILE A C      1 
ATOM   2033 O O      . ILE A 1 140 ? 25.76100 -0.59100  -2.38800  1.000 27.93000  ? 140 ILE A O      1 
ATOM   2034 C CB     . ILE A 1 140 ? 27.88700 0.21600   -0.29000  1.000 31.97000  ? 140 ILE A CB     1 
ATOM   2035 C CG1    . ILE A 1 140 ? 28.29400 0.45500   1.14000   1.000 40.02000  ? 140 ILE A CG1    1 
ATOM   2036 C CG2    . ILE A 1 140 ? 28.90700 0.80000   -1.30200  1.000 37.39000  ? 140 ILE A CG2    1 
ATOM   2037 C CD1    . ILE A 1 140 ? 29.22900 -0.65800  1.67200   1.000 40.11000  ? 140 ILE A CD1    1 
ATOM   2038 H H      . ILE A 1 140 ? 25.57900 -0.74300  0.31100   1.000 30.74000  ? 140 ILE A H      1 
ATOM   2039 H HA     . ILE A 1 140 ? 26.45400 1.73500   -0.35100  1.000 38.48000  ? 140 ILE A HA     1 
ATOM   2040 H HB     . ILE A 1 140 ? 27.87300 -0.74200  -0.44300  1.000 38.75000  ? 140 ILE A HB     1 
ATOM   2041 H HG12   . ILE A 1 140 ? 28.76500 1.30100   1.20000   1.000 48.40000  ? 140 ILE A HG12   1 
ATOM   2042 H HG13   . ILE A 1 140 ? 27.50100 0.47700   1.69800   1.000 48.40000  ? 140 ILE A HG13   1 
ATOM   2043 H HG21   . ILE A 1 140 ? 29.78100 0.41700   -1.12700  1.000 45.25000  ? 140 ILE A HG21   1 
ATOM   2044 H HG22   . ILE A 1 140 ? 28.62300 0.57600   -2.20200  1.000 45.25000  ? 140 ILE A HG22   1 
ATOM   2045 H HG23   . ILE A 1 140 ? 28.94200 1.76400   -1.19600  1.000 45.25000  ? 140 ILE A HG23   1 
ATOM   2046 H HD11   . ILE A 1 140 ? 29.40300 -0.50100  2.61400   1.000 48.51000  ? 140 ILE A HD11   1 
ATOM   2047 H HD12   . ILE A 1 140 ? 28.79700 -1.51700  1.55400   1.000 48.51000  ? 140 ILE A HD12   1 
ATOM   2048 H HD13   . ILE A 1 140 ? 30.06200 -0.63500  1.17500   1.000 48.51000  ? 140 ILE A HD13   1 
ATOM   2049 N N      . SER A 1 141 ? 26.09000 1.63000   -2.76100  1.000 28.36000  ? 141 SER A N      1 
ATOM   2050 C CA     . SER A 1 141 ? 25.51400 1.46400   -4.07100  1.000 35.21000  ? 141 SER A CA     1 
ATOM   2051 C C      . SER A 1 141 ? 26.12500 2.38800   -5.09900  1.000 32.14000  ? 141 SER A C      1 
ATOM   2052 O O      . SER A 1 141 ? 26.54400 3.50600   -4.78900  1.000 29.14000  ? 141 SER A O      1 
ATOM   2053 C CB     . SER A 1 141 ? 24.02100 1.69300   -3.99200  1.000 31.40000  ? 141 SER A CB     1 
ATOM   2054 O OG     . SER A 1 141 ? 23.43800 1.02600   -5.07600  1.000 39.60000  ? 141 SER A OG     1 
ATOM   2055 H H      . SER A 1 141 ? 26.41700 2.40100   -2.56500  1.000 34.42000  ? 141 SER A H      1 
ATOM   2056 H HA     . SER A 1 141 ? 25.71800 0.56900   -4.38600  1.000 42.64000  ? 141 SER A HA     1 
ATOM   2057 H HB2    . SER A 1 141 ? 23.67600 1.33400   -3.15900  1.000 38.06000  ? 141 SER A HB2    1 
ATOM   2058 H HB3    . SER A 1 141 ? 23.82900 2.64200   -4.04800  1.000 38.06000  ? 141 SER A HB3    1 
ATOM   2059 H HG     . SER A 1 141 ? 23.65600 0.21500   -5.06500  1.000 47.90000  ? 141 SER A HG     1 
ATOM   2060 N N      . LYS A 1 142 ? 26.11600 1.92900   -6.33900  1.000 33.50000  ? 142 LYS A N      1 
ATOM   2061 C CA     . LYS A 1 142 ? 26.76000 2.66200   -7.42500  1.000 46.84000  ? 142 LYS A CA     1 
ATOM   2062 C C      . LYS A 1 142 ? 26.02600 2.35400   -8.72500  1.000 27.08000  ? 142 LYS A C      1 
ATOM   2063 O O      . LYS A 1 142 ? 26.09400 1.22700   -9.24200  1.000 38.06000  ? 142 LYS A O      1 
ATOM   2064 C CB     . LYS A 1 142 ? 28.23400 2.29500   -7.51100  1.000 43.06000  ? 142 LYS A CB     1 
ATOM   2065 C CG     . LYS A 1 142 ? 28.89900 2.59400   -8.83900  1.000 47.67000  ? 142 LYS A CG     1 
ATOM   2066 C CD     . LYS A 1 142 ? 29.54500 4.00000   -8.85300  1.000 52.27000  ? 142 LYS A CD     1 
ATOM   2067 C CE     . LYS A 1 142 ? 30.12000 4.36800   -10.23900 1.000 61.94000  ? 142 LYS A CE     1 
ATOM   2068 N NZ     . LYS A 1 142 ? 29.10000 4.68300   -11.27600 1.000 47.78000  ? 142 LYS A NZ     1 
ATOM   2069 H H      . LYS A 1 142 ? 25.74400 1.19300   -6.58300  1.000 40.58000  ? 142 LYS A H      1 
ATOM   2070 H HA     . LYS A 1 142 ? 26.68300 3.61600   -7.26800  1.000 56.59000  ? 142 LYS A HA     1 
ATOM   2071 H HB2    . LYS A 1 142 ? 28.71300 2.79100   -6.82900  1.000 52.06000  ? 142 LYS A HB2    1 
ATOM   2072 H HB3    . LYS A 1 142 ? 28.32100 1.34200   -7.35100  1.000 52.06000  ? 142 LYS A HB3    1 
ATOM   2073 H HG2    . LYS A 1 142 ? 29.59500 1.93800   -9.00300  1.000 57.59000  ? 142 LYS A HG2    1 
ATOM   2074 H HG3    . LYS A 1 142 ? 28.23600 2.55700   -9.54600  1.000 57.59000  ? 142 LYS A HG3    1 
ATOM   2075 H HD2    . LYS A 1 142 ? 28.87400 4.66100   -8.62000  1.000 63.11000  ? 142 LYS A HD2    1 
ATOM   2076 H HD3    . LYS A 1 142 ? 30.27000 4.02300   -8.21000  1.000 63.11000  ? 142 LYS A HD3    1 
ATOM   2077 H HE2    . LYS A 1 142 ? 30.68600 5.14900   -10.14100 1.000 74.71000  ? 142 LYS A HE2    1 
ATOM   2078 H HE3    . LYS A 1 142 ? 30.64300 3.61800   -10.56500 1.000 74.71000  ? 142 LYS A HE3    1 
ATOM   2079 H HZ1    . LYS A 1 142 ? 29.49900 4.86500   -12.05100 1.000 57.72000  ? 142 LYS A HZ1    1 
ATOM   2080 H HZ2    . LYS A 1 142 ? 28.55500 3.98900   -11.38800 1.000 57.72000  ? 142 LYS A HZ2    1 
ATOM   2081 H HZ3    . LYS A 1 142 ? 28.62000 5.39000   -11.02600 1.000 57.72000  ? 142 LYS A HZ3    1 
ATOM   2082 N N      . HIS A 1 143 ? 25.33900 3.36600   -9.23900  1.000 46.47000  ? 143 HIS A N      1 
ATOM   2083 C CA     . HIS A 1 143 ? 24.64100 3.31900   -10.51300 1.000 44.00000  ? 143 HIS A CA     1 
ATOM   2084 C C      . HIS A 1 143 ? 25.58800 3.84100   -11.58800 1.000 41.45000  ? 143 HIS A C      1 
ATOM   2085 O O      . HIS A 1 143 ? 26.31300 4.81900   -11.36300 1.000 37.17000  ? 143 HIS A O      1 
ATOM   2086 C CB     . HIS A 1 143 ? 23.37200 4.18000   -10.42200 1.000 42.12000  ? 143 HIS A CB     1 
ATOM   2087 C CG     . HIS A 1 143 ? 22.39700 3.95200   -11.53600 1.000 61.48000  ? 143 HIS A CG     1 
ATOM   2088 N ND1    . HIS A 1 143 ? 22.56400 4.51000   -12.78500 1.000 41.85000  ? 143 HIS A ND1    1 
ATOM   2089 C CD2    . HIS A 1 143 ? 21.23900 3.25200   -11.58600 1.000 49.55000  ? 143 HIS A CD2    1 
ATOM   2090 C CE1    . HIS A 1 143 ? 21.56400 4.15000   -13.56400 1.000 49.03000  ? 143 HIS A CE1    1 
ATOM   2091 N NE2    . HIS A 1 143 ? 20.75700 3.37400   -12.86500 1.000 50.74000  ? 143 HIS A NE2    1 
ATOM   2092 H H      . HIS A 1 143 ? 25.25900 4.12800   -8.84900  1.000 56.15000  ? 143 HIS A H      1 
ATOM   2093 H HA     . HIS A 1 143 ? 24.37000 2.41800   -10.75200 1.000 53.18000  ? 143 HIS A HA     1 
ATOM   2094 H HB2    . HIS A 1 143 ? 22.91800 3.97900   -9.58900  1.000 50.92000  ? 143 HIS A HB2    1 
ATOM   2095 H HB3    . HIS A 1 143 ? 23.62900 5.11500   -10.44300 1.000 50.92000  ? 143 HIS A HB3    1 
ATOM   2096 H HD2    . HIS A 1 143 ? 20.84500 2.78000   -10.88800 1.000 59.84000  ? 143 HIS A HD2    1 
ATOM   2097 H HE1    . HIS A 1 143 ? 21.44700 4.39900   -14.45300 1.000 59.22000  ? 143 HIS A HE1    1 
ATOM   2098 H HE2    . HIS A 1 143 ? 20.04200 3.00200   -13.16400 1.000 61.27000  ? 143 HIS A HE2    1 
ATOM   2099 N N      . ASN A 1 144 ? 25.60200 3.18500   -12.74900 1.000 48.23000  ? 144 ASN A N      1 
ATOM   2100 C CA     . ASN A 1 144 ? 26.35300 3.73500   -13.88700 1.000 38.98000  ? 144 ASN A CA     1 
ATOM   2101 C C      . ASN A 1 144 ? 26.08400 5.25300   -13.98600 1.000 51.58000  ? 144 ASN A C      1 
ATOM   2102 O O      . ASN A 1 144 ? 24.95500 5.71800   -13.78400 1.000 49.80000  ? 144 ASN A O      1 
ATOM   2103 C CB     . ASN A 1 144 ? 25.92300 3.07700   -15.21900 1.000 27.28000  ? 144 ASN A CB     1 
ATOM   2104 C CG     . ASN A 1 144 ? 26.59500 1.78700   -15.49800 1.000 37.57000  ? 144 ASN A CG     1 
ATOM   2105 O OD1    . ASN A 1 144 ? 27.61400 1.42700   -14.84700 1.000 39.72000  ? 144 ASN A OD1    1 
ATOM   2106 N ND2    . ASN A 1 144 ? 26.09300 1.05200   -16.54800 1.000 34.05000  ? 144 ASN A ND2    1 
ATOM   2107 H H      . ASN A 1 144 ? 25.19700 2.44200   -12.90300 1.000 58.26000  ? 144 ASN A H      1 
ATOM   2108 H HA     . ASN A 1 144 ? 27.29700 3.55600   -13.75600 1.000 47.16000  ? 144 ASN A HA     1 
ATOM   2109 H HB2    . ASN A 1 144 ? 24.96800 2.91200   -15.19100 1.000 33.12000  ? 144 ASN A HB2    1 
ATOM   2110 H HB3    . ASN A 1 144 ? 26.13400 3.68200   -15.94800 1.000 33.12000  ? 144 ASN A HB3    1 
ATOM   2111 H HD21   . ASN A 1 144 ? 25.42500 1.35000   -17.00100 1.000 41.24000  ? 144 ASN A HD21   1 
ATOM   2112 H HD22   . ASN A 1 144 ? 26.44700 0.29500   -16.75200 1.000 41.24000  ? 144 ASN A HD22   1 
ATOM   2113 N N      . ASP A 1 145 ? 27.11800 6.02000   -14.30800 1.000 40.09000  ? 145 ASP A N      1 
ATOM   2114 C CA     . ASP A 1 145 ? 27.03500 7.46700   -14.50400 1.000 67.96000  ? 145 ASP A CA     1 
ATOM   2115 C C      . ASP A 1 145 ? 26.65600 8.22200   -13.22800 1.000 52.36000  ? 145 ASP A C      1 
ATOM   2116 O O      . ASP A 1 145 ? 26.16500 9.35300   -13.29200 1.000 56.79000  ? 145 ASP A O      1 
ATOM   2117 C CB     . ASP A 1 145 ? 26.05100 7.83000   -15.63900 1.000 67.81000  ? 145 ASP A CB     1 
ATOM   2118 C CG     . ASP A 1 145 ? 26.27800 7.00800   -16.91200 1.000 63.04000  ? 145 ASP A CG     1 
ATOM   2119 O OD1    . ASP A 1 145 ? 27.42600 6.58900   -17.16300 1.000 67.45000  ? 145 ASP A OD1    1 
ATOM   2120 O OD2    . ASP A 1 145 ? 25.29300 6.76700   -17.65200 1.000 61.47000  ? 145 ASP A OD2    1 
ATOM   2121 H H      . ASP A 1 145 ? 27.91300 5.71400   -14.42400 1.000 48.49000  ? 145 ASP A H      1 
ATOM   2122 H HA     . ASP A 1 145 ? 27.91900 7.77100   -14.76200 1.000 81.93000  ? 145 ASP A HA     1 
ATOM   2123 H HB2    . ASP A 1 145 ? 25.14400 7.66600   -15.33600 1.000 81.76000  ? 145 ASP A HB2    1 
ATOM   2124 H HB3    . ASP A 1 145 ? 26.16000 8.76700   -15.86500 1.000 81.76000  ? 145 ASP A HB3    1 
ATOM   2125 N N      . ASP A 1 146 ? 26.81700 7.63000   -12.05400 1.000 61.65000  ? 146 ASP A N      1 
ATOM   2126 C CA     . ASP A 1 146 ? 26.68400 8.40300   -10.82000 1.000 54.14000  ? 146 ASP A CA     1 
ATOM   2127 C C      . ASP A 1 146 ? 27.68500 7.84500   -9.82700  1.000 45.29000  ? 146 ASP A C      1 
ATOM   2128 O O      . ASP A 1 146 ? 28.32600 6.80800   -10.07400 1.000 49.82000  ? 146 ASP A O      1 
ATOM   2129 C CB     . ASP A 1 146 ? 25.27200 8.37400   -10.23100 1.000 53.49000  ? 146 ASP A CB     1 
ATOM   2130 C CG     . ASP A 1 146 ? 25.07500 9.40700   -9.08400  1.000 60.89000  ? 146 ASP A CG     1 
ATOM   2131 O OD1    . ASP A 1 146 ? 26.04300 10.07100  -8.62800  1.000 57.66000  ? 146 ASP A OD1    1 
ATOM   2132 O OD2    . ASP A 1 146 ? 23.92800 9.56700   -8.62300  1.000 57.26000  ? 146 ASP A OD2    1 
ATOM   2133 H H      A ASP A 1 146 ? 27.00000 6.79700   -11.94400 0.390 74.36000  ? 146 ASP A H      1 
ATOM   2134 H H      B ASP A 1 146 ? 27.00000 6.79700   -11.94400 0.610 74.36000  ? 146 ASP A H      1 
ATOM   2135 H HA     . ASP A 1 146 ? 26.88500 9.33200   -11.01400 1.000 65.35000  ? 146 ASP A HA     1 
ATOM   2136 H HB2    . ASP A 1 146 ? 24.63300 8.57900   -10.93200 1.000 64.57000  ? 146 ASP A HB2    1 
ATOM   2137 H HB3    . ASP A 1 146 ? 25.09800 7.49000   -9.87200  1.000 64.57000  ? 146 ASP A HB3    1 
ATOM   2138 N N      . GLU A 1 147 ? 27.85400 8.56300   -8.72400  1.000 46.01000  ? 147 GLU A N      1 
ATOM   2139 C CA     . GLU A 1 147 ? 28.90200 8.23000   -7.76800  1.000 48.06000  ? 147 GLU A CA     1 
ATOM   2140 C C      . GLU A 1 147 ? 28.42500 7.14200   -6.79100  1.000 42.93000  ? 147 GLU A C      1 
ATOM   2141 O O      . GLU A 1 147 ? 27.22400 6.82400   -6.69300  1.000 44.58000  ? 147 GLU A O      1 
ATOM   2142 C CB     . GLU A 1 147 ? 29.33400 9.48600   -7.02500  1.000 43.52000  ? 147 GLU A CB     1 
ATOM   2143 C CG     . GLU A 1 147 ? 30.15900 10.47200  -7.88100  1.000 47.25000  ? 147 GLU A CG     1 
ATOM   2144 C CD     . GLU A 1 147 ? 31.47400 9.85000   -8.36700  1.000 67.96000  ? 147 GLU A CD     1 
ATOM   2145 O OE1    . GLU A 1 147 ? 31.44500 9.20300   -9.43300  1.000 80.91000  ? 147 GLU A OE1    1 
ATOM   2146 O OE2    . GLU A 1 147 ? 32.51500 9.96700   -7.67300  1.000 92.68000  ? 147 GLU A OE2    1 
ATOM   2147 H H      . GLU A 1 147 ? 27.37800 9.24500   -8.50700  1.000 55.60000  ? 147 GLU A H      1 
ATOM   2148 H HA     . GLU A 1 147 ? 29.67300 7.87500   -8.23800  1.000 58.05000  ? 147 GLU A HA     1 
ATOM   2149 H HB2    . GLU A 1 147 ? 28.54200 9.95400   -6.71800  1.000 52.60000  ? 147 GLU A HB2    1 
ATOM   2150 H HB3    . GLU A 1 147 ? 29.88000 9.22600   -6.26600  1.000 52.60000  ? 147 GLU A HB3    1 
ATOM   2151 H HG2    . GLU A 1 147 ? 29.64100 10.73000  -8.65900  1.000 57.08000  ? 147 GLU A HG2    1 
ATOM   2152 H HG3    . GLU A 1 147 ? 30.37200 11.25500  -7.35000  1.000 57.08000  ? 147 GLU A HG3    1 
ATOM   2153 N N      . GLN A 1 148 ? 29.39100 6.56600   -6.06600  1.000 40.85000  ? 148 GLN A N      1 
ATOM   2154 C CA     . GLN A 1 148 ? 29.10300 5.55800   -5.06300  1.000 38.76000  ? 148 GLN A CA     1 
ATOM   2155 C C      . GLN A 1 148 ? 28.75000 6.22200   -3.75400  1.000 39.55000  ? 148 GLN A C      1 
ATOM   2156 O O      . GLN A 1 148 ? 29.52700 7.04900   -3.23900  1.000 35.62000  ? 148 GLN A O      1 
ATOM   2157 C CB     . GLN A 1 148 ? 30.30000 4.64100   -4.87700  1.000 30.92000  ? 148 GLN A CB     1 
ATOM   2158 C CG     . GLN A 1 148 ? 30.12300 3.47100   -3.86500  1.000 31.19000  ? 148 GLN A CG     1 
ATOM   2159 C CD     . GLN A 1 148 ? 31.16100 2.34300   -4.09800  1.000 35.21000  ? 148 GLN A CD     1 
ATOM   2160 O OE1    . GLN A 1 148 ? 31.53900 2.02600   -5.19900  1.000 30.64000  ? 148 GLN A OE1    1 
ATOM   2161 N NE2    . GLN A 1 148 ? 31.65200 1.77700   -3.01700  1.000 26.59000  ? 148 GLN A NE2    1 
ATOM   2162 H H      . GLN A 1 148 ? 30.22700 6.75000   -6.14300  1.000 49.40000  ? 148 GLN A H      1 
ATOM   2163 H HA     . GLN A 1 148 ? 28.34800 5.02200   -5.35200  1.000 46.89000  ? 148 GLN A HA     1 
ATOM   2164 H HB2    . GLN A 1 148 ? 30.51300 4.24500   -5.73600  1.000 37.49000  ? 148 GLN A HB2    1 
ATOM   2165 H HB3    . GLN A 1 148 ? 31.04500 5.17700   -4.56500  1.000 37.49000  ? 148 GLN A HB3    1 
ATOM   2166 H HG2    . GLN A 1 148 ? 30.23900 3.80800   -2.96300  1.000 37.81000  ? 148 GLN A HG2    1 
ATOM   2167 H HG3    . GLN A 1 148 ? 29.23600 3.09200   -3.96600  1.000 37.81000  ? 148 GLN A HG3    1 
ATOM   2168 H HE21   . GLN A 1 148 ? 31.39300 2.03800   -2.23900  1.000 32.28000  ? 148 GLN A HE21   1 
ATOM   2169 H HE22   . GLN A 1 148 ? 32.23200 1.14600   -3.08700  1.000 32.28000  ? 148 GLN A HE22   1 
ATOM   2170 N N      . TYR A 1 149 ? 27.57000 5.84900   -3.21900  1.000 32.26000  ? 149 TYR A N      1 
ATOM   2171 C CA     . TYR A 1 149 ? 27.07500 6.32300   -1.93100  1.000 34.50000  ? 149 TYR A CA     1 
ATOM   2172 C C      . TYR A 1 149 ? 26.86000 5.18100   -0.95600  1.000 37.65000  ? 149 TYR A C      1 
ATOM   2173 O O      . TYR A 1 149 ? 26.78300 4.01100   -1.34600  1.000 37.91000  ? 149 TYR A O      1 
ATOM   2174 C CB     . TYR A 1 149 ? 25.74500 7.08200   -2.10000  1.000 28.56000  ? 149 TYR A CB     1 
ATOM   2175 C CG     . TYR A 1 149 ? 25.92200 8.36600   -2.84200  1.000 33.06000  ? 149 TYR A CG     1 
ATOM   2176 C CD1    . TYR A 1 149 ? 25.95700 8.37700   -4.22100  1.000 42.74000  ? 149 TYR A CD1    1 
ATOM   2177 C CD2    . TYR A 1 149 ? 26.16000 9.54400   -2.16400  1.000 44.98000  ? 149 TYR A CD2    1 
ATOM   2178 C CE1    . TYR A 1 149 ? 26.20400 9.53700   -4.90600  1.000 43.06000  ? 149 TYR A CE1    1 
ATOM   2179 C CE2    . TYR A 1 149 ? 26.39300 10.69900  -2.84000  1.000 44.58000  ? 149 TYR A CE2    1 
ATOM   2180 C CZ     . TYR A 1 149 ? 26.40700 10.69600  -4.21900  1.000 42.89000  ? 149 TYR A CZ     1 
ATOM   2181 O OH     . TYR A 1 149 ? 26.62800 11.84900  -4.94000  1.000 75.28000  ? 149 TYR A OH     1 
ATOM   2182 H H      . TYR A 1 149 ? 27.02700 5.30400   -3.60400  1.000 39.09000  ? 149 TYR A H      1 
ATOM   2183 H HA     . TYR A 1 149 ? 27.74700 6.91100   -1.55200  1.000 41.78000  ? 149 TYR A HA     1 
ATOM   2184 H HB2    . TYR A 1 149 ? 25.12300 6.52700   -2.59600  1.000 34.65000  ? 149 TYR A HB2    1 
ATOM   2185 H HB3    . TYR A 1 149 ? 25.38100 7.28500   -1.22400  1.000 34.65000  ? 149 TYR A HB3    1 
ATOM   2186 H HD1    . TYR A 1 149 ? 25.81100 7.58800   -4.69100  1.000 51.67000  ? 149 TYR A HD1    1 
ATOM   2187 H HD2    . TYR A 1 149 ? 26.16100 9.54800   -1.23400  1.000 54.36000  ? 149 TYR A HD2    1 
ATOM   2188 H HE1    . TYR A 1 149 ? 26.23300 9.53300   -5.83500  1.000 52.06000  ? 149 TYR A HE1    1 
ATOM   2189 H HE2    . TYR A 1 149 ? 26.54400 11.49000  -2.37500  1.000 53.88000  ? 149 TYR A HE2    1 
ATOM   2190 H HH     . TYR A 1 149 ? 26.81100 12.48300  -4.41900  1.000 90.72000  ? 149 TYR A HH     1 
ATOM   2191 N N      . VAL A 1 150 ? 26.79500 5.54000   0.32900   1.000 34.53000  ? 150 VAL A N      1 
ATOM   2192 C CA     . VAL A 1 150 ? 26.43800 4.59900   1.38800   1.000 36.47000  ? 150 VAL A CA     1 
ATOM   2193 C C      . VAL A 1 150 ? 25.30000 5.17200   2.20900   1.000 40.35000  ? 150 VAL A C      1 
ATOM   2194 O O      . VAL A 1 150 ? 25.33800 6.34300   2.58700   1.000 41.16000  ? 150 VAL A O      1 
ATOM   2195 C CB     . VAL A 1 150 ? 27.63400 4.27400   2.30900   1.000 37.28000  ? 150 VAL A CB     1 
ATOM   2196 C CG1    . VAL A 1 150 ? 28.36700 5.49700   2.75100   1.000 48.40000  ? 150 VAL A CG1    1 
ATOM   2197 C CG2    . VAL A 1 150 ? 27.17200 3.54200   3.57100   1.000 37.38000  ? 150 VAL A CG2    1 
ATOM   2198 H H      . VAL A 1 150 ? 26.95500 6.33600   0.61300   1.000 41.81000  ? 150 VAL A H      1 
ATOM   2199 H HA     . VAL A 1 150 ? 26.13000 3.78000   0.96900   1.000 44.15000  ? 150 VAL A HA     1 
ATOM   2200 H HB     . VAL A 1 150 ? 28.23000 3.71600   1.78400   1.000 45.11000  ? 150 VAL A HB     1 
ATOM   2201 H HG11   . VAL A 1 150 ? 29.10400 5.23400   3.32400   1.000 58.46000  ? 150 VAL A HG11   1 
ATOM   2202 H HG12   . VAL A 1 150 ? 28.70500 5.96200   1.97000   1.000 58.46000  ? 150 VAL A HG12   1 
ATOM   2203 H HG13   . VAL A 1 150 ? 27.75700 6.07200   3.24000   1.000 58.46000  ? 150 VAL A HG13   1 
ATOM   2204 H HG21   . VAL A 1 150 ? 27.94400 3.35300   4.12700   1.000 45.24000  ? 150 VAL A HG21   1 
ATOM   2205 H HG22   . VAL A 1 150 ? 26.54800 4.10700   4.05300   1.000 45.24000  ? 150 VAL A HG22   1 
ATOM   2206 H HG23   . VAL A 1 150 ? 26.73800 2.71300   3.31500   1.000 45.24000  ? 150 VAL A HG23   1 
ATOM   2207 N N      . TRP A 1 151 ? 24.29200 4.34400   2.46300   1.000 31.82000  ? 151 TRP A N      1 
ATOM   2208 C CA     . TRP A 1 151 ? 23.10900 4.66600   3.23700   1.000 34.71000  ? 151 TRP A CA     1 
ATOM   2209 C C      . TRP A 1 151 ? 23.15200 3.86100   4.51800   1.000 35.09000  ? 151 TRP A C      1 
ATOM   2210 O O      . TRP A 1 151 ? 23.52300 2.69400   4.51200   1.000 43.34000  ? 151 TRP A O      1 
ATOM   2211 C CB     . TRP A 1 151 ? 21.86800 4.36300   2.38200   1.000 35.55000  ? 151 TRP A CB     1 
ATOM   2212 C CG     . TRP A 1 151 ? 20.48500 4.40700   3.02000   1.000 37.09000  ? 151 TRP A CG     1 
ATOM   2213 C CD1    . TRP A 1 151 ? 19.54200 5.39800   2.85900   1.000 40.05000  ? 151 TRP A CD1    1 
ATOM   2214 C CD2    . TRP A 1 151 ? 19.87900 3.42100   3.85100   1.000 45.03000  ? 151 TRP A CD2    1 
ATOM   2215 N NE1    . TRP A 1 151 ? 18.39100 5.08100   3.52600   1.000 51.94000  ? 151 TRP A NE1    1 
ATOM   2216 C CE2    . TRP A 1 151 ? 18.57200 3.87000   4.14600   1.000 56.96000  ? 151 TRP A CE2    1 
ATOM   2217 C CE3    . TRP A 1 151 ? 20.30900 2.19600   4.37500   1.000 49.20000  ? 151 TRP A CE3    1 
ATOM   2218 C CZ2    . TRP A 1 151 ? 17.70800 3.15100   4.95500   1.000 43.93000  ? 151 TRP A CZ2    1 
ATOM   2219 C CZ3    . TRP A 1 151 ? 19.44200 1.46700   5.15600   1.000 54.07000  ? 151 TRP A CZ3    1 
ATOM   2220 C CH2    . TRP A 1 151 ? 18.16200 1.96600   5.47600   1.000 45.46000  ? 151 TRP A CH2    1 
ATOM   2221 H HA     . TRP A 1 151 ? 23.06100 5.60000   3.49700   1.000 42.03000  ? 151 TRP A HA     1 
ATOM   2222 H HB2    . TRP A 1 151 ? 21.85200 5.00800   1.65700   1.000 43.05000  ? 151 TRP A HB2    1 
ATOM   2223 H HB3    . TRP A 1 151 ? 21.97400 3.46700   2.02700   1.000 43.05000  ? 151 TRP A HB3    1 
ATOM   2224 H HD1    . TRP A 1 151 ? 19.67000 6.17500   2.36400   1.000 48.45000  ? 151 TRP A HD1    1 
ATOM   2225 H HE1    . TRP A 1 151 ? 17.67700 5.55800   3.55200   1.000 62.71000  ? 151 TRP A HE1    1 
ATOM   2226 H HE3    . TRP A 1 151 ? 21.16500 1.88000   4.19700   1.000 59.42000  ? 151 TRP A HE3    1 
ATOM   2227 H HZ2    . TRP A 1 151 ? 16.85000 3.46100   5.13800   1.000 53.10000  ? 151 TRP A HZ2    1 
ATOM   2228 H HZ3    . TRP A 1 151 ? 19.70400 0.63400   5.47700   1.000 65.27000  ? 151 TRP A HZ3    1 
ATOM   2229 H HH2    . TRP A 1 151 ? 17.61500 1.48300   6.05200   1.000 54.94000  ? 151 TRP A HH2    1 
ATOM   2230 N N      . GLU A 1 152 ? 22.79500 4.48300   5.61400   1.000 37.19000  ? 152 GLU A N      1 
ATOM   2231 C CA     . GLU A 1 152 ? 22.94200 3.84000   6.91000   1.000 45.78000  ? 152 GLU A CA     1 
ATOM   2232 C C      . GLU A 1 152 ? 21.78900 4.10900   7.86600   1.000 49.89000  ? 152 GLU A C      1 
ATOM   2233 O O      . GLU A 1 152 ? 21.30700 5.24200   7.99100   1.000 41.00000  ? 152 GLU A O      1 
ATOM   2234 C CB     . GLU A 1 152 ? 24.24800 4.29100   7.58500   1.000 34.25000  ? 152 GLU A CB     1 
ATOM   2235 C CG     . GLU A 1 152 ? 24.62900 3.40300   8.78100   1.000 53.85000  ? 152 GLU A CG     1 
ATOM   2236 C CD     . GLU A 1 152 ? 26.05800 3.61800   9.25200   1.000 48.33000  ? 152 GLU A CD     1 
ATOM   2237 O OE1    . GLU A 1 152 ? 26.66900 4.63800   8.85200   1.000 50.27000  ? 152 GLU A OE1    1 
ATOM   2238 O OE2    . GLU A 1 152 ? 26.55300 2.76100   10.03600  1.000 35.93000  ? 152 GLU A OE2    1 
ATOM   2239 H H      . GLU A 1 152 ? 22.46500 5.27700   5.64100   1.000 45.01000  ? 152 GLU A H      1 
ATOM   2240 H HA     . GLU A 1 152 ? 22.93200 2.88300   6.74900   1.000 55.32000  ? 152 GLU A HA     1 
ATOM   2241 H HB2    . GLU A 1 152 ? 24.96900 4.25100   6.93800   1.000 41.48000  ? 152 GLU A HB2    1 
ATOM   2242 H HB3    . GLU A 1 152 ? 24.14100 5.20000   7.90700   1.000 41.48000  ? 152 GLU A HB3    1 
ATOM   2243 H HG2    . GLU A 1 152 ? 24.03700 3.60300   9.52300   1.000 65.00000  ? 152 GLU A HG2    1 
ATOM   2244 H HG3    . GLU A 1 152 ? 24.53600 2.47200   8.52400   1.000 65.00000  ? 152 GLU A HG3    1 
ATOM   2245 N N      . SER A 1 153 ? 21.40900 3.04500   8.57600   1.000 52.62000  ? 153 SER A N      1 
ATOM   2246 C CA     . SER A 1 153 ? 20.29700 3.04900   9.50200   1.000 60.74000  ? 153 SER A CA     1 
ATOM   2247 C C      . SER A 1 153 ? 20.60500 2.20200   10.72600  1.000 78.88000  ? 153 SER A C      1 
ATOM   2248 O O      . SER A 1 153 ? 21.32500 1.20100   10.64300  1.000 58.31000  ? 153 SER A O      1 
ATOM   2249 C CB     . SER A 1 153 ? 19.02800 2.47500   8.84400   1.000 67.78000  ? 153 SER A CB     1 
ATOM   2250 O OG     . SER A 1 153 ? 18.17600 1.86300   9.80500   1.000 76.24000  ? 153 SER A OG     1 
ATOM   2251 H H      . SER A 1 153 ? 21.80200 2.28100   8.53100   1.000 63.53000  ? 153 SER A H      1 
ATOM   2252 H HA     . SER A 1 153 ? 20.15000 3.96300   9.79200   1.000 73.27000  ? 153 SER A HA     1 
ATOM   2253 H HB2    . SER A 1 153 ? 18.54500 3.19700   8.41200   1.000 81.72000  ? 153 SER A HB2    1 
ATOM   2254 H HB3    . SER A 1 153 ? 19.28900 1.81100   8.18700   1.000 81.72000  ? 153 SER A HB3    1 
ATOM   2255 H HG     . SER A 1 153 ? 17.37300 2.03700   9.63000   1.000 91.87000  ? 153 SER A HG     1 
ATOM   2256 N N      . ASN A 1 154 ? 20.01400 2.60900   11.86000  1.000 102.26000 ? 154 ASN A N      1 
ATOM   2257 C CA     . ASN A 1 154 ? 20.05600 1.87600   13.12400  1.000 79.57000  ? 154 ASN A CA     1 
ATOM   2258 C C      . ASN A 1 154 ? 18.67400 1.36300   13.52500  1.000 77.45000  ? 154 ASN A C      1 
ATOM   2259 O O      . ASN A 1 154 ? 18.44400 1.07400   14.70200  1.000 87.77000  ? 154 ASN A O      1 
ATOM   2260 C CB     . ASN A 1 154 ? 20.62300 2.78700   14.22200  1.000 77.11000  ? 154 ASN A CB     1 
ATOM   2261 C CG     . ASN A 1 154 ? 19.86200 4.13400   14.32700  1.000 96.92000  ? 154 ASN A CG     1 
ATOM   2262 O OD1    . ASN A 1 154 ? 19.15800 4.54700   13.39100  1.000 87.05000  ? 154 ASN A OD1    1 
ATOM   2263 N ND2    . ASN A 1 154 ? 20.00400 4.81200   15.46600  1.000 92.59000  ? 154 ASN A ND2    1 
ATOM   2264 H H      . ASN A 1 154 ? 19.56400 3.33900   11.92000  1.000 123.10000 ? 154 ASN A H      1 
ATOM   2265 H HA     . ASN A 1 154 ? 20.63700 1.10500   13.02900  1.000 95.86000  ? 154 ASN A HA     1 
ATOM   2266 H HB2    . ASN A 1 154 ? 20.55300 2.33400   15.07700  1.000 92.91000  ? 154 ASN A HB2    1 
ATOM   2267 H HB3    . ASN A 1 154 ? 21.55300 2.98100   14.02400  1.000 92.91000  ? 154 ASN A HB3    1 
ATOM   2268 H HD21   . ASN A 1 154 ? 20.49800 4.49600   16.09500  1.000 111.49000 ? 154 ASN A HD21   1 
ATOM   2269 H HD22   . ASN A 1 154 ? 19.60100 5.56400   15.57100  1.000 111.49000 ? 154 ASN A HD22   1 
ATOM   2270 N N      . ALA A 1 155 ? 17.73900 1.27900   12.57700  1.000 86.47000  ? 155 ALA A N      1 
ATOM   2271 C CA     . ALA A 1 155 ? 16.33800 0.92900   12.81700  1.000 99.26000  ? 155 ALA A CA     1 
ATOM   2272 C C      . ALA A 1 155 ? 15.59900 2.00700   13.60800  1.000 106.25000 ? 155 ALA A C      1 
ATOM   2273 O O      . ALA A 1 155 ? 14.49500 1.76700   14.12000  1.000 119.11000 ? 155 ALA A O      1 
ATOM   2274 C CB     . ALA A 1 155 ? 16.20900 -0.42400  13.53000  1.000 89.78000  ? 155 ALA A CB     1 
ATOM   2275 H H      . ALA A 1 155 ? 17.90100 1.42900   11.74600  1.000 104.15000 ? 155 ALA A H      1 
ATOM   2276 H HA     . ALA A 1 155 ? 15.89900 0.84800   11.95600  1.000 119.49000 ? 155 ALA A HA     1 
ATOM   2277 H HB1    . ALA A 1 155 ? 15.32700 -0.78900  13.35900  1.000 108.12000 ? 155 ALA A HB1    1 
ATOM   2278 H HB2    . ALA A 1 155 ? 16.88900 -1.02700  13.18900  1.000 108.12000 ? 155 ALA A HB2    1 
ATOM   2279 H HB3    . ALA A 1 155 ? 16.33300 -0.29100  14.48300  1.000 108.12000 ? 155 ALA A HB3    1 
ATOM   2280 N N      . GLY A 1 156 ? 16.18500 3.19800   13.70900  1.000 96.28000  ? 156 GLY A N      1 
ATOM   2281 C CA     . GLY A 1 156 ? 15.60900 4.26600   14.49400  1.000 93.83000  ? 156 GLY A CA     1 
ATOM   2282 C C      . GLY A 1 156 ? 14.78000 5.23500   13.67400  1.000 100.67000 ? 156 GLY A C      1 
ATOM   2283 O O      . GLY A 1 156 ? 13.94600 4.83000   12.84800  1.000 77.77000  ? 156 GLY A O      1 
ATOM   2284 H H      . GLY A 1 156 ? 16.92600 3.40800   13.32600  1.000 115.92000 ? 156 GLY A H      1 
ATOM   2285 H HA2    . GLY A 1 156 ? 15.03700 3.88300   15.17800  1.000 112.98000 ? 156 GLY A HA2    1 
ATOM   2286 H HA3    . GLY A 1 156 ? 16.32200 4.76500   14.92200  1.000 112.98000 ? 156 GLY A HA3    1 
ATOM   2287 N N      . GLY A 1 157 ? 15.00600 6.52800   13.90000  1.000 97.66000  ? 157 GLY A N      1 
ATOM   2288 C CA     . GLY A 1 157 ? 14.16400 7.54400   13.31800  1.000 79.25000  ? 157 GLY A CA     1 
ATOM   2289 C C      . GLY A 1 157 ? 14.83500 8.36300   12.23900  1.000 79.22000  ? 157 GLY A C      1 
ATOM   2290 O O      . GLY A 1 157 ? 14.19200 9.16000   11.55100  1.000 81.08000  ? 157 GLY A O      1 
ATOM   2291 H H      . GLY A 1 157 ? 15.64500 6.83300   14.38900  1.000 117.58000 ? 157 GLY A H      1 
ATOM   2292 H HA2    . GLY A 1 157 ? 13.38400 7.12000   12.92900  1.000 95.48000  ? 157 GLY A HA2    1 
ATOM   2293 H HA3    . GLY A 1 157 ? 13.87700 8.15200   14.01800  1.000 95.48000  ? 157 GLY A HA3    1 
ATOM   2294 N N      . LYS A 1 158 ? 16.13100 8.20900   12.09100  1.000 66.98000  ? 158 LYS A N      1 
ATOM   2295 C CA     . LYS A 1 158 ? 16.87700 8.93100   11.08000  1.000 71.51000  ? 158 LYS A CA     1 
ATOM   2296 C C      . LYS A 1 158 ? 17.70000 7.91900   10.28400  1.000 62.35000  ? 158 LYS A C      1 
ATOM   2297 O O      . LYS A 1 158 ? 17.90000 6.77200   10.70100  1.000 59.11000  ? 158 LYS A O      1 
ATOM   2298 C CB     . LYS A 1 158 ? 17.71000 10.02600  11.73800  1.000 48.87000  ? 158 LYS A CB     1 
ATOM   2299 H H      . LYS A 1 158 ? 16.61200 7.68300   12.57200  1.000 80.76000  ? 158 LYS A H      1 
ATOM   2300 H HA     . LYS A 1 158 ? 16.30700 9.37500   10.43300  1.000 86.19000  ? 158 LYS A HA     1 
ATOM   2301 N N      . PHE A 1 159 ? 18.08900 8.32000   9.07100   1.000 55.51000  ? 159 PHE A N      1 
ATOM   2302 C CA     . PHE A 1 159 ? 19.05400 7.55500   8.28300   1.000 51.35000  ? 159 PHE A CA     1 
ATOM   2303 C C      . PHE A 1 159 ? 19.95600 8.56900   7.60000   1.000 54.24000  ? 159 PHE A C      1 
ATOM   2304 O O      . PHE A 1 159 ? 19.51700 9.68500   7.29400   1.000 50.99000  ? 159 PHE A O      1 
ATOM   2305 C CB     . PHE A 1 159 ? 18.43300 6.62400   7.23000   1.000 47.60000  ? 159 PHE A CB     1 
ATOM   2306 C CG     . PHE A 1 159 ? 17.66400 7.34100   6.15800   1.000 53.41000  ? 159 PHE A CG     1 
ATOM   2307 C CD1    . PHE A 1 159 ? 18.30300 7.79700   5.00400   1.000 50.41000  ? 159 PHE A CD1    1 
ATOM   2308 C CD2    . PHE A 1 159 ? 16.29600 7.57600   6.31500   1.000 56.73000  ? 159 PHE A CD2    1 
ATOM   2309 C CE1    . PHE A 1 159 ? 17.57900 8.48900   4.00300   1.000 59.65000  ? 159 PHE A CE1    1 
ATOM   2310 C CE2    . PHE A 1 159 ? 15.56800 8.26200   5.32900   1.000 65.92000  ? 159 PHE A CE2    1 
ATOM   2311 C CZ     . PHE A 1 159 ? 16.20500 8.71300   4.16600   1.000 64.26000  ? 159 PHE A CZ     1 
ATOM   2312 H H      . PHE A 1 159 ? 17.80600 9.03300   8.68300   1.000 66.99000  ? 159 PHE A H      1 
ATOM   2313 H HA     . PHE A 1 159 ? 19.55600 6.97300   8.87400   1.000 62.00000  ? 159 PHE A HA     1 
ATOM   2314 H HB2    . PHE A 1 159 ? 19.14500 6.12500   6.79900   1.000 57.51000  ? 159 PHE A HB2    1 
ATOM   2315 H HB3    . PHE A 1 159 ? 17.82300 6.01600   7.67500   1.000 57.51000  ? 159 PHE A HB3    1 
ATOM   2316 H HD1    . PHE A 1 159 ? 19.21300 7.64500   4.89000   1.000 60.88000  ? 159 PHE A HD1    1 
ATOM   2317 H HD2    . PHE A 1 159 ? 15.86300 7.27500   7.08100   1.000 68.46000  ? 159 PHE A HD2    1 
ATOM   2318 H HE1    . PHE A 1 159 ? 18.01300 8.79400   3.24000   1.000 71.96000  ? 159 PHE A HE1    1 
ATOM   2319 H HE2    . PHE A 1 159 ? 14.65900 8.41600   5.44800   1.000 79.49000  ? 159 PHE A HE2    1 
ATOM   2320 H HZ     . PHE A 1 159 ? 15.72100 9.15800   3.50900   1.000 77.49000  ? 159 PHE A HZ     1 
ATOM   2321 N N      . THR A 1 160 ? 21.21900 8.19400   7.37400   1.000 53.33000  ? 160 THR A N      1 
ATOM   2322 C CA     . THR A 1 160 ? 22.12000 9.04900   6.62700   1.000 55.15000  ? 160 THR A CA     1 
ATOM   2323 C C      . THR A 1 160 ? 22.30900 8.51600   5.23400   1.000 46.74000  ? 160 THR A C      1 
ATOM   2324 O O      . THR A 1 160 ? 22.14400 7.33000   4.96300   1.000 49.82000  ? 160 THR A O      1 
ATOM   2325 C CB     . THR A 1 160 ? 23.50700 9.14700   7.26500   1.000 52.33000  ? 160 THR A CB     1 
ATOM   2326 O OG1    . THR A 1 160 ? 23.89400 7.84000   7.69500   1.000 60.46000  ? 160 THR A OG1    1 
ATOM   2327 C CG2    . THR A 1 160 ? 23.46500 10.08600  8.42900   1.000 57.66000  ? 160 THR A CG2    1 
ATOM   2328 H H      . THR A 1 160 ? 21.56500 7.45400   7.64400   1.000 64.37000  ? 160 THR A H      1 
ATOM   2329 H HA     . THR A 1 160 ? 21.72500 9.93500   6.60900   1.000 66.56000  ? 160 THR A HA     1 
ATOM   2330 H HB     . THR A 1 160 ? 24.16100 9.48600   6.63500   1.000 63.17000  ? 160 THR A HB     1 
ATOM   2331 H HG1    . THR A 1 160 ? 24.67300 7.85900   8.01000   1.000 72.93000  ? 160 THR A HG1    1 
ATOM   2332 H HG21   . THR A 1 160 ? 24.33500 10.12400  8.85600   1.000 69.57000  ? 160 THR A HG21   1 
ATOM   2333 H HG22   . THR A 1 160 ? 23.22200 10.97600  8.12800   1.000 69.57000  ? 160 THR A HG22   1 
ATOM   2334 H HG23   . THR A 1 160 ? 22.80900 9.78300   9.07600   1.000 69.57000  ? 160 THR A HG23   1 
ATOM   2335 N N      . VAL A 1 161 ? 22.73200 9.40900   4.35900   1.000 38.73000  ? 161 VAL A N      1 
ATOM   2336 C CA     . VAL A 1 161 ? 23.20600 9.06100   3.02600   1.000 42.29000  ? 161 VAL A CA     1 
ATOM   2337 C C      . VAL A 1 161 ? 24.45400 9.89800   2.82000   1.000 38.86000  ? 161 VAL A C      1 
ATOM   2338 O O      . VAL A 1 161 ? 24.44000 11.09700  3.10600   1.000 54.78000  ? 161 VAL A O      1 
ATOM   2339 C CB     . VAL A 1 161 ? 22.18800 9.36700   1.91900   1.000 44.41000  ? 161 VAL A CB     1 
ATOM   2340 C CG1    . VAL A 1 161 ? 22.87100 9.32600   0.59100   1.000 39.35000  ? 161 VAL A CG1    1 
ATOM   2341 C CG2    . VAL A 1 161 ? 21.08600 8.35800   1.98500   1.000 35.10000  ? 161 VAL A CG2    1 
ATOM   2342 H H      . VAL A 1 161 ? 22.75700 10.25500  4.51600   1.000 46.86000  ? 161 VAL A H      1 
ATOM   2343 H HA     . VAL A 1 161 ? 23.39900 8.11200   2.97600   1.000 51.13000  ? 161 VAL A HA     1 
ATOM   2344 H HB     . VAL A 1 161 ? 21.80700 10.25200  2.03600   1.000 53.68000  ? 161 VAL A HB     1 
ATOM   2345 H HG11   . VAL A 1 161 ? 23.58700 8.67200   0.62500   1.000 47.60000  ? 161 VAL A HG11   1 
ATOM   2346 H HG12   . VAL A 1 161 ? 22.22500 9.07400   -0.08800  1.000 47.60000  ? 161 VAL A HG12   1 
ATOM   2347 H HG13   . VAL A 1 161 ? 23.23300 10.20400  0.39500   1.000 47.60000  ? 161 VAL A HG13   1 
ATOM   2348 H HG21   . VAL A 1 161 ? 21.02100 8.02000   2.89200   1.000 42.50000  ? 161 VAL A HG21   1 
ATOM   2349 H HG22   . VAL A 1 161 ? 20.25300 8.78300   1.72900   1.000 42.50000  ? 161 VAL A HG22   1 
ATOM   2350 H HG23   . VAL A 1 161 ? 21.28700 7.63100   1.37500   1.000 42.50000  ? 161 VAL A HG23   1 
ATOM   2351 N N      . THR A 1 162 ? 25.54800 9.28500   2.38600   1.000 40.94000  ? 162 THR A N      1 
ATOM   2352 C CA     . THR A 1 162 ? 26.78900 10.03800  2.30000   1.000 39.97000  ? 162 THR A CA     1 
ATOM   2353 C C      . THR A 1 162 ? 27.64400 9.42400   1.20300   1.000 38.24000  ? 162 THR A C      1 
ATOM   2354 O O      . THR A 1 162 ? 27.53600 8.23700   0.89300   1.000 56.34000  ? 162 THR A O      1 
ATOM   2355 C CB     . THR A 1 162 ? 27.51200 10.14600  3.68700   1.000 44.81000  ? 162 THR A CB     1 
ATOM   2356 O OG1    . THR A 1 162 ? 28.80800 9.54400   3.64600   1.000 56.05000  ? 162 THR A OG1    1 
ATOM   2357 C CG2    . THR A 1 162 ? 26.71100 9.53200   4.85000   1.000 50.61000  ? 162 THR A CG2    1 
ATOM   2358 H H      . THR A 1 162 ? 25.59500 8.46100   2.14400   1.000 49.51000  ? 162 THR A H      1 
ATOM   2359 H HA     . THR A 1 162 ? 26.62200 10.95600  2.03300   1.000 48.34000  ? 162 THR A HA     1 
ATOM   2360 H HB     . THR A 1 162 ? 27.59900 11.09400  3.87100   1.000 54.15000  ? 162 THR A HB     1 
ATOM   2361 H HG1    . THR A 1 162 ? 28.73500 8.70900   3.58000   1.000 67.65000  ? 162 THR A HG1    1 
ATOM   2362 H HG21   . THR A 1 162 ? 25.90400 10.04700  5.00400   1.000 61.11000  ? 162 THR A HG21   1 
ATOM   2363 H HG22   . THR A 1 162 ? 26.46600 8.61800   4.63800   1.000 61.11000  ? 162 THR A HG22   1 
ATOM   2364 H HG23   . THR A 1 162 ? 27.24600 9.53500   5.65900   1.000 61.11000  ? 162 THR A HG23   1 
ATOM   2365 N N      . LEU A 1 163 ? 28.46600 10.26100  0.59300   1.000 39.80000  ? 163 LEU A N      1 
ATOM   2366 C CA     . LEU A 1 163 ? 29.32100 9.81500   -0.49200  1.000 50.28000  ? 163 LEU A CA     1 
ATOM   2367 C C      . LEU A 1 163 ? 30.39300 8.88500   0.05700   1.000 46.28000  ? 163 LEU A C      1 
ATOM   2368 O O      . LEU A 1 163 ? 30.93100 9.11500   1.13700   1.000 39.88000  ? 163 LEU A O      1 
ATOM   2369 C CB     . LEU A 1 163 ? 29.93600 11.02700  -1.19500  1.000 40.14000  ? 163 LEU A CB     1 
ATOM   2370 C CG     . LEU A 1 163 ? 30.79500 10.71400  -2.41900  1.000 53.33000  ? 163 LEU A CG     1 
ATOM   2371 C CD1    . LEU A 1 163 ? 30.11100 10.64700  -3.74400  1.000 50.05000  ? 163 LEU A CD1    1 
ATOM   2372 C CD2    . LEU A 1 163 ? 31.87500 11.82300  -2.45500  1.000 53.26000  ? 163 LEU A CD2    1 
ATOM   2373 H H      . LEU A 1 163 ? 28.54800 11.09400  0.78800   1.000 48.14000  ? 163 LEU A H      1 
ATOM   2374 H HA     . LEU A 1 163 ? 28.81200 9.32400   -1.15600  1.000 60.72000  ? 163 LEU A HA     1 
ATOM   2375 H HB2    . LEU A 1 163 ? 29.21600 11.60700  -1.48800  1.000 48.55000  ? 163 LEU A HB2    1 
ATOM   2376 H HB3    . LEU A 1 163 ? 30.50000 11.49300  -0.55800  1.000 48.55000  ? 163 LEU A HB3    1 
ATOM   2377 H HG     . LEU A 1 163 ? 31.13300 9.81100   -2.31400  1.000 64.38000  ? 163 LEU A HG     1 
ATOM   2378 H HD11   . LEU A 1 163 ? 30.75700 10.39100  -4.42100  1.000 60.44000  ? 163 LEU A HD11   1 
ATOM   2379 H HD12   . LEU A 1 163 ? 29.40000 9.98900   -3.70000  1.000 60.44000  ? 163 LEU A HD12   1 
ATOM   2380 H HD13   . LEU A 1 163 ? 29.74100 11.52000  -3.95300  1.000 60.44000  ? 163 LEU A HD13   1 
ATOM   2381 H HD21   . LEU A 1 163 ? 32.41700 11.71000  -3.25100  1.000 64.30000  ? 163 LEU A HD21   1 
ATOM   2382 H HD22   . LEU A 1 163 ? 31.43800 12.68900  -2.47400  1.000 64.30000  ? 163 LEU A HD22   1 
ATOM   2383 H HD23   . LEU A 1 163 ? 32.43000 11.75000  -1.66300  1.000 64.30000  ? 163 LEU A HD23   1 
ATOM   2384 N N      . ASP A 1 164 ? 30.72100 7.84300   -0.71100  1.000 51.33000  ? 164 ASP A N      1 
ATOM   2385 C CA     . ASP A 1 164 ? 31.41600 6.66900   -0.18000  1.000 43.26000  ? 164 ASP A CA     1 
ATOM   2386 C C      . ASP A 1 164 ? 32.91400 6.83000   -0.39000  1.000 42.76000  ? 164 ASP A C      1 
ATOM   2387 O O      . ASP A 1 164 ? 33.45100 6.60200   -1.48500  1.000 38.06000  ? 164 ASP A O      1 
ATOM   2388 C CB     . ASP A 1 164 ? 30.90800 5.39400   -0.83100  1.000 39.11000  ? 164 ASP A CB     1 
ATOM   2389 C CG     . ASP A 1 164 ? 31.57000 4.16500   -0.27800  1.000 40.61000  ? 164 ASP A CG     1 
ATOM   2390 O OD1    . ASP A 1 164 ? 32.54700 4.31400   0.48200   1.000 45.30000  ? 164 ASP A OD1    1 
ATOM   2391 O OD2    . ASP A 1 164 ? 31.08100 3.04600   -0.56800  1.000 39.19000  ? 164 ASP A OD2    1 
ATOM   2392 H H      . ASP A 1 164 ? 30.55000 7.79300   -1.55300  1.000 61.98000  ? 164 ASP A H      1 
ATOM   2393 H HA     . ASP A 1 164 ? 31.24800 6.62400   0.77400   1.000 52.29000  ? 164 ASP A HA     1 
ATOM   2394 H HB2    . ASP A 1 164 ? 29.95300 5.31800   -0.67600  1.000 47.31000  ? 164 ASP A HB2    1 
ATOM   2395 H HB3    . ASP A 1 164 ? 31.08800 5.43100   -1.78300  1.000 47.31000  ? 164 ASP A HB3    1 
ATOM   2396 N N      . GLU A 1 165 ? 33.59600 7.12600   0.70600   1.000 36.72000  ? 165 GLU A N      1 
ATOM   2397 C CA     . GLU A 1 165 ? 35.02300 7.37400   0.70100   1.000 41.82000  ? 165 GLU A CA     1 
ATOM   2398 C C      . GLU A 1 165 ? 35.78400 6.38800   1.55600   1.000 50.56000  ? 165 GLU A C      1 
ATOM   2399 O O      . GLU A 1 165 ? 36.97100 6.60400   1.83300   1.000 45.46000  ? 165 GLU A O      1 
ATOM   2400 C CB     . GLU A 1 165 ? 35.27700 8.81300   1.17000   1.000 42.67000  ? 165 GLU A CB     1 
ATOM   2401 C CG     . GLU A 1 165 ? 34.69400 9.81300   0.23400   1.000 54.82000  ? 165 GLU A CG     1 
ATOM   2402 C CD     . GLU A 1 165 ? 34.98700 11.21400  0.65600   1.000 59.19000  ? 165 GLU A CD     1 
ATOM   2403 O OE1    . GLU A 1 165 ? 35.23500 11.43400  1.88900   1.000 54.72000  ? 165 GLU A OE1    1 
ATOM   2404 O OE2    . GLU A 1 165 ? 34.96300 12.08300  -0.25900  1.000 51.26000  ? 165 GLU A OE2    1 
ATOM   2405 H H      . GLU A 1 165 ? 33.24200 7.19100   1.48700   1.000 44.45000  ? 165 GLU A H      1 
ATOM   2406 H HA     . GLU A 1 165 ? 35.36900 7.28200   -0.20000  1.000 50.56000  ? 165 GLU A HA     1 
ATOM   2407 H HB2    . GLU A 1 165 ? 34.87200 8.94100   2.04200   1.000 51.59000  ? 165 GLU A HB2    1 
ATOM   2408 H HB3    . GLU A 1 165 ? 36.23300 8.96700   1.22200   1.000 51.59000  ? 165 GLU A HB3    1 
ATOM   2409 H HG2    . GLU A 1 165 ? 35.06800 9.67800   -0.65100  1.000 66.16000  ? 165 GLU A HG2    1 
ATOM   2410 H HG3    . GLU A 1 165 ? 33.73000 9.70000   0.20700   1.000 66.16000  ? 165 GLU A HG3    1 
ATOM   2411 N N      . THR A 1 166 ? 35.15200 5.29900   1.95400   1.000 37.21000  ? 166 THR A N      1 
ATOM   2412 C CA     . THR A 1 166 ? 35.83000 4.34500   2.81800   1.000 39.18000  ? 166 THR A CA     1 
ATOM   2413 C C      . THR A 1 166 ? 35.74300 2.88100   2.40800   1.000 43.21000  ? 166 THR A C      1 
ATOM   2414 O O      . THR A 1 166 ? 36.49400 2.05900   2.98100   1.000 34.94000  ? 166 THR A O      1 
ATOM   2415 C CB     . THR A 1 166 ? 35.29900 4.48800   4.24700   1.000 38.42000  ? 166 THR A CB     1 
ATOM   2416 O OG1    . THR A 1 166 ? 33.92000 4.18000   4.28100   1.000 43.71000  ? 166 THR A OG1    1 
ATOM   2417 C CG2    . THR A 1 166 ? 35.46800 5.93000   4.70400   1.000 35.30000  ? 166 THR A CG2    1 
ATOM   2418 H H      . THR A 1 166 ? 34.34400 5.09100   1.74300   1.000 45.03000  ? 166 THR A H      1 
ATOM   2419 H HA     . THR A 1 166 ? 36.77500 4.56100   2.80300   1.000 47.40000  ? 166 THR A HA     1 
ATOM   2420 H HB     . THR A 1 166 ? 35.78300 3.88800   4.83700   1.000 46.48000  ? 166 THR A HB     1 
ATOM   2421 H HG1    . THR A 1 166 ? 33.61500 4.31100   5.05300   1.000 52.83000  ? 166 THR A HG1    1 
ATOM   2422 H HG21   . THR A 1 166 ? 35.06500 6.05100   5.57800   1.000 42.74000  ? 166 THR A HG21   1 
ATOM   2423 H HG22   . THR A 1 166 ? 36.41100 6.15200   4.75800   1.000 42.74000  ? 166 THR A HG22   1 
ATOM   2424 H HG23   . THR A 1 166 ? 35.04000 6.53000   4.07400   1.000 42.74000  ? 166 THR A HG23   1 
ATOM   2425 N N      . ASN A 1 167 ? 34.90100 2.52700   1.41900   1.000 39.83000  ? 167 ASN A N      1 
ATOM   2426 C CA     . ASN A 1 167 ? 34.66400 1.13700   1.02800   1.000 28.65000  ? 167 ASN A CA     1 
ATOM   2427 C C      . ASN A 1 167 ? 35.30500 0.79700   -0.32300  1.000 37.07000  ? 167 ASN A C      1 
ATOM   2428 O O      . ASN A 1 167 ? 35.56200 1.64900   -1.16200  1.000 39.53000  ? 167 ASN A O      1 
ATOM   2429 C CB     . ASN A 1 167 ? 33.16000 0.82600   0.96100   1.000 39.69000  ? 167 ASN A CB     1 
ATOM   2430 C CG     . ASN A 1 167 ? 32.46400 1.00100   2.26000   1.000 38.78000  ? 167 ASN A CG     1 
ATOM   2431 O OD1    . ASN A 1 167 ? 31.84800 2.03600   2.52500   1.000 42.31000  ? 167 ASN A OD1    1 
ATOM   2432 N ND2    . ASN A 1 167 ? 32.46300 -0.05800  3.04900   1.000 28.27000  ? 167 ASN A ND2    1 
ATOM   2433 H H      . ASN A 1 167 ? 34.45000 3.09200   0.95300   1.000 48.18000  ? 167 ASN A H      1 
ATOM   2434 H HA     . ASN A 1 167 ? 35.07800 0.57200   1.69900   1.000 34.76000  ? 167 ASN A HA     1 
ATOM   2435 H HB2    . ASN A 1 167 ? 32.74500 1.42200   0.31800   1.000 48.01000  ? 167 ASN A HB2    1 
ATOM   2436 H HB3    . ASN A 1 167 ? 33.04200 -0.09600  0.68200   1.000 48.01000  ? 167 ASN A HB3    1 
ATOM   2437 H HD21   . ASN A 1 167 ? 32.84900 -0.78300  2.79500   1.000 34.30000  ? 167 ASN A HD21   1 
ATOM   2438 H HD22   . ASN A 1 167 ? 32.07700 -0.02200  3.81600   1.000 34.30000  ? 167 ASN A HD22   1 
ATOM   2439 N N      . GLU A 1 168 ? 35.54500 -0.48600  -0.54100  1.000 38.04000  ? 168 GLU A N      1 
ATOM   2440 C CA     . GLU A 1 168 ? 35.93100 -0.96600  -1.87000  1.000 41.59000  ? 168 GLU A CA     1 
ATOM   2441 C C      . GLU A 1 168 ? 34.94100 -0.45100  -2.91700  1.000 37.18000  ? 168 GLU A C      1 
ATOM   2442 O O      . GLU A 1 168 ? 33.75500 -0.29300  -2.65000  1.000 32.34000  ? 168 GLU A O      1 
ATOM   2443 C CB     . GLU A 1 168 ? 35.97200 -2.49800  -1.88000  1.000 25.10000  ? 168 GLU A CB     1 
ATOM   2444 C CG     . GLU A 1 168 ? 34.77800 -3.07400  -1.11100  1.000 54.61000  ? 168 GLU A CG     1 
ATOM   2445 C CD     . GLU A 1 168 ? 34.78200 -4.58400  -1.00000  1.000 67.80000  ? 168 GLU A CD     1 
ATOM   2446 O OE1    . GLU A 1 168 ? 34.99000 -5.24600  -2.06300  1.000 53.30000  ? 168 GLU A OE1    1 
ATOM   2447 O OE2    . GLU A 1 168 ? 34.56100 -5.09800  0.15100   1.000 66.08000  ? 168 GLU A OE2    1 
ATOM   2448 H H      . GLU A 1 168 ? 35.49300 -1.10200  0.05600   1.000 46.03000  ? 168 GLU A H      1 
ATOM   2449 H HA     . GLU A 1 168 ? 36.81600 -0.64100  -2.09900  1.000 50.29000  ? 168 GLU A HA     1 
ATOM   2450 H HB2    . GLU A 1 168 ? 35.93300 -2.81700  -2.79600  1.000 30.50000  ? 168 GLU A HB2    1 
ATOM   2451 H HB3    . GLU A 1 168 ? 36.78900 -2.80300  -1.45700  1.000 30.50000  ? 168 GLU A HB3    1 
ATOM   2452 H HG2    . GLU A 1 168 ? 34.78600 -2.71400  -0.21000  1.000 65.91000  ? 168 GLU A HG2    1 
ATOM   2453 H HG3    . GLU A 1 168 ? 33.96100 -2.81500  -1.56500  1.000 65.91000  ? 168 GLU A HG3    1 
ATOM   2454 N N      . ARG A 1 169 ? 35.44300 -0.14600  -4.10800  1.000 24.84000  ? 169 ARG A N      1 
ATOM   2455 C CA     . ARG A 1 169 ? 34.60400 0.26500   -5.23100  1.000 33.20000  ? 169 ARG A CA     1 
ATOM   2456 C C      . ARG A 1 169 ? 33.81500 -0.91900  -5.73600  1.000 33.84000  ? 169 ARG A C      1 
ATOM   2457 O O      . ARG A 1 169 ? 34.36300 -2.01900  -5.88200  1.000 36.50000  ? 169 ARG A O      1 
ATOM   2458 C CB     . ARG A 1 169 ? 35.43700 0.78800   -6.42200  1.000 24.80000  ? 169 ARG A CB     1 
ATOM   2459 C CG     . ARG A 1 169 ? 36.31700 2.05700   -6.11100  1.000 25.75000  ? 169 ARG A CG     1 
ATOM   2460 C CD     . ARG A 1 169 ? 35.55400 3.20500   -5.51400  1.000 31.57000  ? 169 ARG A CD     1 
ATOM   2461 N NE     . ARG A 1 169 ? 35.39700 3.22600   -4.07400  1.000 36.11000  ? 169 ARG A NE     1 
ATOM   2462 C CZ     . ARG A 1 169 ? 34.78200 4.22400   -3.45600  1.000 38.37000  ? 169 ARG A CZ     1 
ATOM   2463 N NH1    . ARG A 1 169 ? 34.22900 5.20000   -4.12300  1.000 34.04000  ? 169 ARG A NH1    1 
ATOM   2464 N NH2    . ARG A 1 169 ? 34.70100 4.23000   -2.13600  1.000 27.35000  ? 169 ARG A NH2    1 
ATOM   2465 H H      . ARG A 1 169 ? 36.28200 -0.16900  -4.29800  1.000 30.19000  ? 169 ARG A H      1 
ATOM   2466 H HA     . ARG A 1 169 ? 34.02400 0.97700   -4.91900  1.000 40.22000  ? 169 ARG A HA     1 
ATOM   2467 H HB2    . ARG A 1 169 ? 36.03700 0.08200   -6.71000  1.000 30.15000  ? 169 ARG A HB2    1 
ATOM   2468 H HB3    . ARG A 1 169 ? 34.83000 1.02200   -7.14100  1.000 30.15000  ? 169 ARG A HB3    1 
ATOM   2469 H HG2    . ARG A 1 169 ? 37.01100 1.80800   -5.48200  1.000 31.28000  ? 169 ARG A HG2    1 
ATOM   2470 H HG3    . ARG A 1 169 ? 36.71500 2.36900   -6.93900  1.000 31.28000  ? 169 ARG A HG3    1 
ATOM   2471 H HD2    . ARG A 1 169 ? 36.01100 4.02500   -5.75800  1.000 38.27000  ? 169 ARG A HD2    1 
ATOM   2472 H HD3    . ARG A 1 169 ? 34.66100 3.19800   -5.89200  1.000 38.27000  ? 169 ARG A HD3    1 
ATOM   2473 H HE     . ARG A 1 169 ? 35.71200 2.57500   -3.60800  1.000 43.71000  ? 169 ARG A HE     1 
ATOM   2474 H HH11   . ARG A 1 169 ? 34.25900 5.20500   -4.98200  1.000 41.23000  ? 169 ARG A HH11   1 
ATOM   2475 H HH12   . ARG A 1 169 ? 33.83400 5.83800   -3.70300  1.000 41.23000  ? 169 ARG A HH12   1 
ATOM   2476 H HH21   . ARG A 1 169 ? 35.04700 3.58800   -1.68100  1.000 33.20000  ? 169 ARG A HH21   1 
ATOM   2477 H HH22   . ARG A 1 169 ? 34.30200 4.87700   -1.73300  1.000 33.20000  ? 169 ARG A HH22   1 
ATOM   2478 N N      . LEU A 1 170 ? 32.51200 -0.71000  -5.97100  1.000 36.22000  ? 170 LEU A N      1 
ATOM   2479 C CA     . LEU A 1 170 ? 31.68100 -1.82200  -6.45400  1.000 28.04000  ? 170 LEU A CA     1 
ATOM   2480 C C      . LEU A 1 170 ? 31.81200 -1.99500  -7.96300  1.000 32.21000  ? 170 LEU A C      1 
ATOM   2481 O O      . LEU A 1 170 ? 31.65200 -3.10500  -8.50200  1.000 32.34000  ? 170 LEU A O      1 
ATOM   2482 C CB     . LEU A 1 170 ? 30.21000 -1.60000  -6.11900  1.000 30.89000  ? 170 LEU A CB     1 
ATOM   2483 C CG     . LEU A 1 170 ? 29.94600 -1.44600  -4.62100  1.000 28.42000  ? 170 LEU A CG     1 
ATOM   2484 C CD1    . LEU A 1 170 ? 28.47200 -1.27600  -4.31600  1.000 32.23000  ? 170 LEU A CD1    1 
ATOM   2485 C CD2    . LEU A 1 170 ? 30.40000 -2.68700  -3.98900  1.000 24.50000  ? 170 LEU A CD2    1 
ATOM   2486 H H      . LEU A 1 170 ? 32.10000 0.03700   -5.86200  1.000 43.85000  ? 170 LEU A H      1 
ATOM   2487 H HA     . LEU A 1 170 ? 31.97100 -2.63000  -6.00200  1.000 34.03000  ? 170 LEU A HA     1 
ATOM   2488 H HB2    . LEU A 1 170 ? 29.90700 -0.79000  -6.56000  1.000 37.44000  ? 170 LEU A HB2    1 
ATOM   2489 H HB3    . LEU A 1 170 ? 29.69800 -2.36100  -6.43500  1.000 37.44000  ? 170 LEU A HB3    1 
ATOM   2490 H HG     . LEU A 1 170 ? 30.40600 -0.66000  -4.28500  1.000 34.49000  ? 170 LEU A HG     1 
ATOM   2491 H HD11   . LEU A 1 170 ? 28.36200 -1.12100  -3.36500  1.000 39.05000  ? 170 LEU A HD11   1 
ATOM   2492 H HD12   . LEU A 1 170 ? 28.13100 -0.51800  -4.81600  1.000 39.05000  ? 170 LEU A HD12   1 
ATOM   2493 H HD13   . LEU A 1 170 ? 28.00000 -2.08300  -4.57600  1.000 39.05000  ? 170 LEU A HD13   1 
ATOM   2494 H HD21   . LEU A 1 170 ? 30.02200 -2.74500  -3.09800  1.000 29.79000  ? 170 LEU A HD21   1 
ATOM   2495 H HD22   . LEU A 1 170 ? 30.10400 -3.44000  -4.52400  1.000 29.79000  ? 170 LEU A HD22   1 
ATOM   2496 H HD23   . LEU A 1 170 ? 31.36900 -2.68000  -3.93700  1.000 29.79000  ? 170 LEU A HD23   1 
ATOM   2497 N N      . GLY A 1 171 ? 32.11200 -0.92500  -8.67200  1.000 30.79000  ? 171 GLY A N      1 
ATOM   2498 C CA     . GLY A 1 171 ? 32.11500 -1.01800  -10.13100 1.000 38.53000  ? 171 GLY A CA     1 
ATOM   2499 C C      . GLY A 1 171 ? 30.72800 -0.67300  -10.56700 1.000 42.37000  ? 171 GLY A C      1 
ATOM   2500 O O      . GLY A 1 171 ? 30.52300 0.30200   -11.27600 1.000 42.20000  ? 171 GLY A O      1 
ATOM   2501 H H      . GLY A 1 171 ? 32.31200 -0.15400  -8.35000  1.000 37.33000  ? 171 GLY A H      1 
ATOM   2502 H HA2    . GLY A 1 171 ? 32.75000 -0.39400  -10.51600 1.000 46.62000  ? 171 GLY A HA2    1 
ATOM   2503 H HA3    . GLY A 1 171 ? 32.34000 -1.91700  -10.41900 1.000 46.62000  ? 171 GLY A HA3    1 
ATOM   2504 N N      . ARG A 1 172 ? 29.77100 -1.44900  -10.06300 1.000 33.15000  ? 172 ARG A N      1 
ATOM   2505 C CA     . ARG A 1 172 ? 28.34900 -1.28700  -10.36500 1.000 33.03000  ? 172 ARG A CA     1 
ATOM   2506 C C      . ARG A 1 172 ? 27.58200 -2.27000  -9.51100  1.000 24.51000  ? 172 ARG A C      1 
ATOM   2507 O O      . ARG A 1 172 ? 27.82100 -3.48200  -9.58200  1.000 30.17000  ? 172 ARG A O      1 
ATOM   2508 C CB     . ARG A 1 172 ? 27.99500 -1.53600  -11.84400 1.000 29.01000  ? 172 ARG A CB     1 
ATOM   2509 C CG     . ARG A 1 172 ? 26.54800 -1.05000  -12.15700 1.000 30.36000  ? 172 ARG A CG     1 
ATOM   2510 C CD     . ARG A 1 172 ? 26.06000 -1.54700  -13.48000 1.000 28.83000  ? 172 ARG A CD     1 
ATOM   2511 N NE     . ARG A 1 172 ? 26.11700 -2.99100  -13.51200 1.000 29.82000  ? 172 ARG A NE     1 
ATOM   2512 C CZ     . ARG A 1 172 ? 26.98900 -3.71100  -14.20900 1.000 34.61000  ? 172 ARG A CZ     1 
ATOM   2513 N NH1    . ARG A 1 172 ? 27.94700 -3.13700  -14.93800 1.000 43.33000  ? 172 ARG A NH1    1 
ATOM   2514 N NH2    . ARG A 1 172 ? 26.91700 -5.04000  -14.15500 1.000 34.92000  ? 172 ARG A NH2    1 
ATOM   2515 H H      . ARG A 1 172 ? 29.92300 -2.10000  -9.52300  1.000 40.16000  ? 172 ARG A H      1 
ATOM   2516 H HA     . ARG A 1 172 ? 28.10300 -0.36700  -10.18300 1.000 40.02000  ? 172 ARG A HA     1 
ATOM   2517 H HB2    . ARG A 1 172 ? 28.61300 -1.04800  -12.41100 1.000 35.20000  ? 172 ARG A HB2    1 
ATOM   2518 H HB3    . ARG A 1 172 ? 28.05000 -2.48500  -12.03500 1.000 35.20000  ? 172 ARG A HB3    1 
ATOM   2519 H HG2    . ARG A 1 172 ? 25.94700 -1.37900  -11.47000 1.000 36.81000  ? 172 ARG A HG2    1 
ATOM   2520 H HG3    . ARG A 1 172 ? 26.53400 -0.08100  -12.17500 1.000 36.81000  ? 172 ARG A HG3    1 
ATOM   2521 H HD2    . ARG A 1 172 ? 25.14100 -1.26800  -13.61500 1.000 34.98000  ? 172 ARG A HD2    1 
ATOM   2522 H HD3    . ARG A 1 172 ? 26.62100 -1.19700  -14.18900 1.000 34.98000  ? 172 ARG A HD3    1 
ATOM   2523 H HE     . ARG A 1 172 ? 25.53800 -3.41900  -13.04100 1.000 36.17000  ? 172 ARG A HE     1 
ATOM   2524 H HH11   . ARG A 1 172 ? 28.01100 -2.28000  -14.96500 1.000 52.37000  ? 172 ARG A HH11   1 
ATOM   2525 H HH12   . ARG A 1 172 ? 28.50000 -3.62400  -15.38100 1.000 52.37000  ? 172 ARG A HH12   1 
ATOM   2526 H HH21   . ARG A 1 172 ? 26.31300 -5.41800  -13.67400 1.000 42.29000  ? 172 ARG A HH21   1 
ATOM   2527 H HH22   . ARG A 1 172 ? 27.47500 -5.51900  -14.60100 1.000 42.29000  ? 172 ARG A HH22   1 
ATOM   2528 N N      . GLY A 1 173 ? 26.63600 -1.79200  -8.73600  1.000 30.54000  ? 173 GLY A N      1 
ATOM   2529 C CA     . GLY A 1 173 ? 25.75200 -2.72300  -8.07100  1.000 26.64000  ? 173 GLY A CA     1 
ATOM   2530 C C      . GLY A 1 173 ? 25.51000 -2.30400  -6.67000  1.000 30.66000  ? 173 GLY A C      1 
ATOM   2531 O O      . GLY A 1 173 ? 25.48700 -1.11700  -6.37500  1.000 26.87000  ? 173 GLY A O      1 
ATOM   2532 H H      . GLY A 1 173 ? 26.48800 -0.95900  -8.58200  1.000 37.04000  ? 173 GLY A H      1 
ATOM   2533 H HA2    . GLY A 1 173 ? 24.90300 -2.76000  -8.53800  1.000 32.35000  ? 173 GLY A HA2    1 
ATOM   2534 H HA3    . GLY A 1 173 ? 26.15000 -3.60800  -8.06800  1.000 32.35000  ? 173 GLY A HA3    1 
ATOM   2535 N N      . THR A 1 174 ? 25.33600 -3.25800  -5.78300  1.000 23.06000  ? 174 THR A N      1 
ATOM   2536 C CA     . THR A 1 174 ? 24.86600 -2.88800  -4.45100  1.000 34.00000  ? 174 THR A CA     1 
ATOM   2537 C C      . THR A 1 174 ? 25.41100 -3.91600  -3.47600  1.000 35.06000  ? 174 THR A C      1 
ATOM   2538 O O      . THR A 1 174 ? 25.47600 -5.12900  -3.77400  1.000 29.45000  ? 174 THR A O      1 
ATOM   2539 C CB     . THR A 1 174 ? 23.32200 -2.82900  -4.37800  1.000 33.97000  ? 174 THR A CB     1 
ATOM   2540 O OG1    . THR A 1 174 ? 22.81100 -1.71600  -5.15600  1.000 35.75000  ? 174 THR A OG1    1 
ATOM   2541 C CG2    . THR A 1 174 ? 22.85700 -2.67300  -2.89300  1.000 33.00000  ? 174 THR A CG2    1 
ATOM   2542 H H      . THR A 1 174 ? 25.47600 -4.09600  -5.91500  1.000 28.06000  ? 174 THR A H      1 
ATOM   2543 H HA     . THR A 1 174 ? 25.19600 -2.00900  -4.20700  1.000 41.18000  ? 174 THR A HA     1 
ATOM   2544 H HB     . THR A 1 174 ? 22.96100 -3.65300  -4.74100  1.000 41.15000  ? 174 THR A HB     1 
ATOM   2545 H HG1    . THR A 1 174 ? 21.99000 -1.61300  -5.00600  1.000 43.28000  ? 174 THR A HG1    1 
ATOM   2546 H HG21   . THR A 1 174 ? 21.90300 -2.49800  -2.86100  1.000 39.98000  ? 174 THR A HG21   1 
ATOM   2547 H HG22   . THR A 1 174 ? 23.04500 -3.48600  -2.39900  1.000 39.98000  ? 174 THR A HG22   1 
ATOM   2548 H HG23   . THR A 1 174 ? 23.32700 -1.93500  -2.47400  1.000 39.98000  ? 174 THR A HG23   1 
ATOM   2549 N N      . MET A 1 175 ? 25.77500 -3.44100  -2.30500  1.000 22.32000  ? 175 MET A N      1 
ATOM   2550 C CA     . MET A 1 175 ? 26.29100 -4.33900  -1.28100  1.000 36.40000  ? 175 MET A CA     1 
ATOM   2551 C C      . MET A 1 175 ? 25.65300 -3.93800  0.03500   1.000 24.59000  ? 175 MET A C      1 
ATOM   2552 O O      . MET A 1 175 ? 25.81000 -2.79100  0.47700   1.000 31.23000  ? 175 MET A O      1 
ATOM   2553 C CB     . MET A 1 175 ? 27.83000 -4.26900  -1.18800  1.000 37.82000  ? 175 MET A CB     1 
ATOM   2554 C CG     . MET A 1 175 ? 28.44400 -5.08600  0.01500   1.000 40.32000  ? 175 MET A CG     1 
ATOM   2555 S SD     . MET A 1 175 ? 30.19700 -5.58300  -0.06800  1.000 38.83000  ? 175 MET A SD     1 
ATOM   2556 C CE     . MET A 1 175 ? 30.85900 -4.06700  0.53800   1.000 30.53000  ? 175 MET A CE     1 
ATOM   2557 H H      . MET A 1 175 ? 25.73500 -2.61300  -2.07600  1.000 27.16000  ? 175 MET A H      1 
ATOM   2558 H HA     . MET A 1 175 ? 26.05600 -5.25500  -1.49800  1.000 44.07000  ? 175 MET A HA     1 
ATOM   2559 H HB2    . MET A 1 175 ? 28.20700 -4.62500  -2.00800  1.000 45.76000  ? 175 MET A HB2    1 
ATOM   2560 H HB3    . MET A 1 175 ? 28.09200 -3.34200  -1.07800  1.000 45.76000  ? 175 MET A HB3    1 
ATOM   2561 H HG2    . MET A 1 175 ? 28.35000 -4.54500  0.81400   1.000 48.76000  ? 175 MET A HG2    1 
ATOM   2562 H HG3    . MET A 1 175 ? 27.93100 -5.90400  0.10500   1.000 48.76000  ? 175 MET A HG3    1 
ATOM   2563 H HE1    . MET A 1 175 ? 31.82700 -4.13100  0.55900   1.000 37.02000  ? 175 MET A HE1    1 
ATOM   2564 H HE2    . MET A 1 175 ? 30.58800 -3.34600  -0.05100  1.000 37.02000  ? 175 MET A HE2    1 
ATOM   2565 H HE3    . MET A 1 175 ? 30.51800 -3.90900  1.43200   1.000 37.02000  ? 175 MET A HE3    1 
ATOM   2566 N N      . LEU A 1 176 ? 24.98000 -4.89700  0.66500   1.000 32.91000  ? 176 LEU A N      1 
ATOM   2567 C CA     . LEU A 1 176 ? 24.39400 -4.75400  1.99100   1.000 28.59000  ? 176 LEU A CA     1 
ATOM   2568 C C      . LEU A 1 176 ? 25.36100 -5.29100  3.04400   1.000 41.16000  ? 176 LEU A C      1 
ATOM   2569 O O      . LEU A 1 176 ? 25.92700 -6.36900  2.87000   1.000 33.92000  ? 176 LEU A O      1 
ATOM   2570 C CB     . LEU A 1 176 ? 23.06800 -5.51500  2.03500   1.000 32.59000  ? 176 LEU A CB     1 
ATOM   2571 C CG     . LEU A 1 176 ? 21.80200 -4.79200  1.58200   1.000 38.41000  ? 176 LEU A CG     1 
ATOM   2572 C CD1    . LEU A 1 176 ? 21.87700 -4.27500  0.24100   1.000 35.33000  ? 176 LEU A CD1    1 
ATOM   2573 C CD2    . LEU A 1 176 ? 20.66100 -5.83800  1.67600   1.000 36.16000  ? 176 LEU A CD2    1 
ATOM   2574 H H      . LEU A 1 176 ? 24.84400 -5.67600  0.32700   1.000 39.87000  ? 176 LEU A H      1 
ATOM   2575 H HA     . LEU A 1 176 ? 24.23500 -3.82000  2.19600   1.000 34.69000  ? 176 LEU A HA     1 
ATOM   2576 H HB2    . LEU A 1 176 ? 23.15900 -6.29600  1.46700   1.000 39.49000  ? 176 LEU A HB2    1 
ATOM   2577 H HB3    . LEU A 1 176 ? 22.91800 -5.78800  2.95400   1.000 39.49000  ? 176 LEU A HB3    1 
ATOM   2578 H HG     . LEU A 1 176 ? 21.65000 -4.01500  2.14300   1.000 46.47000  ? 176 LEU A HG     1 
ATOM   2579 H HD11   . LEU A 1 176 ? 21.00200 -3.95200  -0.02300  1.000 42.78000  ? 176 LEU A HD11   1 
ATOM   2580 H HD12   . LEU A 1 176 ? 22.51800 -3.54600  0.21900   1.000 42.78000  ? 176 LEU A HD12   1 
ATOM   2581 H HD13   . LEU A 1 176 ? 22.16300 -4.98400  -0.35600  1.000 42.78000  ? 176 LEU A HD13   1 
ATOM   2582 H HD21   . LEU A 1 176 ? 19.82400 -5.41400  1.42900   1.000 43.78000  ? 176 LEU A HD21   1 
ATOM   2583 H HD22   . LEU A 1 176 ? 20.85300 -6.57000  1.06900   1.000 43.78000  ? 176 LEU A HD22   1 
ATOM   2584 H HD23   . LEU A 1 176 ? 20.60900 -6.16800  2.58600   1.000 43.78000  ? 176 LEU A HD23   1 
ATOM   2585 N N      . ARG A 1 177 ? 25.55500 -4.55100  4.10900   1.000 38.99000  ? 177 ARG A N      1 
ATOM   2586 C CA     . ARG A 1 177 ? 26.44600 -4.94300  5.18700   1.000 34.35000  ? 177 ARG A CA     1 
ATOM   2587 C C      . ARG A 1 177 ? 25.54100 -5.10100  6.39800   1.000 34.88000  ? 177 ARG A C      1 
ATOM   2588 O O      . ARG A 1 177 ? 25.11400 -4.10300  6.99100   1.000 26.92000  ? 177 ARG A O      1 
ATOM   2589 C CB     . ARG A 1 177 ? 27.50500 -3.89800  5.45600   1.000 33.88000  ? 177 ARG A CB     1 
ATOM   2590 C CG     . ARG A 1 177 ? 28.21300 -3.44900  4.23600   1.000 42.67000  ? 177 ARG A CG     1 
ATOM   2591 C CD     . ARG A 1 177 ? 29.51700 -2.72200  4.52200   1.000 59.05000  ? 177 ARG A CD     1 
ATOM   2592 N NE     . ARG A 1 177 ? 30.48200 -3.54200  5.24500   1.000 40.24000  ? 177 ARG A NE     1 
ATOM   2593 C CZ     . ARG A 1 177 ? 31.04100 -3.18200  6.39700   1.000 46.84000  ? 177 ARG A CZ     1 
ATOM   2594 N NH1    . ARG A 1 177 ? 30.81200 -1.99100  6.93300   1.000 57.11000  ? 177 ARG A NH1    1 
ATOM   2595 N NH2    . ARG A 1 177 ? 31.88400 -4.01700  7.00700   1.000 61.10000  ? 177 ARG A NH2    1 
ATOM   2596 H H      . ARG A 1 177 ? 25.17200 -3.79200  4.23900   1.000 47.17000  ? 177 ARG A H      1 
ATOM   2597 H HA     . ARG A 1 177 ? 26.90200 -5.76900  4.96400   1.000 41.60000  ? 177 ARG A HA     1 
ATOM   2598 H HB2    . ARG A 1 177 ? 27.08300 -3.12200  5.85800   1.000 41.03000  ? 177 ARG A HB2    1 
ATOM   2599 H HB3    . ARG A 1 177 ? 28.16400 -4.26900  6.06300   1.000 41.03000  ? 177 ARG A HB3    1 
ATOM   2600 H HG2    . ARG A 1 177 ? 28.42000 -4.22400  3.69000   1.000 51.59000  ? 177 ARG A HG2    1 
ATOM   2601 H HG3    . ARG A 1 177 ? 27.63800 -2.84200  3.74500   1.000 51.59000  ? 177 ARG A HG3    1 
ATOM   2602 H HD2    . ARG A 1 177 ? 29.92200 -2.45700  3.68100   1.000 71.24000  ? 177 ARG A HD2    1 
ATOM   2603 H HD3    . ARG A 1 177 ? 29.32900 -1.93800  5.06200   1.000 71.24000  ? 177 ARG A HD3    1 
ATOM   2604 H HE     . ARG A 1 177 ? 30.70200 -4.30100  4.90700   1.000 48.67000  ? 177 ARG A HE     1 
ATOM   2605 H HH11   . ARG A 1 177 ? 30.29300 -1.43400  6.53500   1.000 68.91000  ? 177 ARG A HH11   1 
ATOM   2606 H HH12   . ARG A 1 177 ? 31.18300 -1.77700  7.67900   1.000 68.91000  ? 177 ARG A HH12   1 
ATOM   2607 H HH21   . ARG A 1 177 ? 32.06100 -4.78200  6.65500   1.000 73.70000  ? 177 ARG A HH21   1 
ATOM   2608 H HH22   . ARG A 1 177 ? 32.24900 -3.79200  7.75200   1.000 73.70000  ? 177 ARG A HH22   1 
ATOM   2609 N N      . LEU A 1 178 ? 25.23300 -6.34700  6.75900   1.000 28.28000  ? 178 LEU A N      1 
ATOM   2610 C CA     . LEU A 1 178 ? 24.43200 -6.61800  7.93300   1.000 38.76000  ? 178 LEU A CA     1 
ATOM   2611 C C      . LEU A 1 178 ? 25.35400 -6.75500  9.14400   1.000 34.30000  ? 178 LEU A C      1 
ATOM   2612 O O      . LEU A 1 178 ? 26.29000 -7.57500  9.14400   1.000 31.99000  ? 178 LEU A O      1 
ATOM   2613 C CB     . LEU A 1 178 ? 23.61400 -7.87500  7.72300   1.000 30.81000  ? 178 LEU A CB     1 
ATOM   2614 C CG     . LEU A 1 178 ? 22.87100 -8.02300  6.40600   1.000 40.95000  ? 178 LEU A CG     1 
ATOM   2615 C CD1    . LEU A 1 178 ? 21.97600 -9.25500  6.37800   1.000 40.77000  ? 178 LEU A CD1    1 
ATOM   2616 C CD2    . LEU A 1 178 ? 22.09100 -6.77000  6.12700   1.000 46.49000  ? 178 LEU A CD2    1 
ATOM   2617 H H      . LEU A 1 178 ? 25.48200 -7.05100  6.33200   1.000 34.32000  ? 178 LEU A H      1 
ATOM   2618 H HA     . LEU A 1 178 ? 23.82300 -5.88200  8.10100   1.000 46.90000  ? 178 LEU A HA     1 
ATOM   2619 H HB2    . LEU A 1 178 ? 24.21500 -8.63400  7.79100   1.000 37.35000  ? 178 LEU A HB2    1 
ATOM   2620 H HB3    . LEU A 1 178 ? 22.94800 -7.91600  8.42600   1.000 37.35000  ? 178 LEU A HB3    1 
ATOM   2621 H HG     . LEU A 1 178 ? 23.51900 -8.15300  5.69600   1.000 49.52000  ? 178 LEU A HG     1 
ATOM   2622 H HD11   . LEU A 1 178 ? 21.55400 -9.31800  5.50700   1.000 49.30000  ? 178 LEU A HD11   1 
ATOM   2623 H HD12   . LEU A 1 178 ? 22.51800 -10.04200 6.54100   1.000 49.30000  ? 178 LEU A HD12   1 
ATOM   2624 H HD13   . LEU A 1 178 ? 21.30000 -9.16900  7.06700   1.000 49.30000  ? 178 LEU A HD13   1 
ATOM   2625 H HD21   . LEU A 1 178 ? 21.46400 -6.94200  5.40700   1.000 56.16000  ? 178 LEU A HD21   1 
ATOM   2626 H HD22   . LEU A 1 178 ? 21.61000 -6.51200  6.92900   1.000 56.16000  ? 178 LEU A HD22   1 
ATOM   2627 H HD23   . LEU A 1 178 ? 22.70600 -6.06600  5.86900   1.000 56.16000  ? 178 LEU A HD23   1 
ATOM   2628 N N      . PHE A 1 179 ? 25.11500 -5.91800  10.15100  1.000 38.68000  ? 179 PHE A N      1 
ATOM   2629 C CA     . PHE A 1 179 ? 25.73400 -6.02200  11.48600  1.000 33.38000  ? 179 PHE A CA     1 
ATOM   2630 C C      . PHE A 1 179 ? 24.89900 -6.99500  12.29800  1.000 28.84000  ? 179 PHE A C      1 
ATOM   2631 O O      . PHE A 1 179 ? 23.86500 -6.62600  12.87800  1.000 37.69000  ? 179 PHE A O      1 
ATOM   2632 C CB     . PHE A 1 179 ? 25.80800 -4.64400  12.13100  1.000 27.28000  ? 179 PHE A CB     1 
ATOM   2633 C CG     . PHE A 1 179 ? 26.75100 -3.74600  11.41600  1.000 46.17000  ? 179 PHE A CG     1 
ATOM   2634 C CD1    . PHE A 1 179 ? 26.36600 -3.12900  10.21700  1.000 36.71000  ? 179 PHE A CD1    1 
ATOM   2635 C CD2    . PHE A 1 179 ? 28.08400 -3.61800  11.86400  1.000 32.06000  ? 179 PHE A CD2    1 
ATOM   2636 C CE1    . PHE A 1 179 ? 27.25700 -2.31300  9.52600   1.000 41.96000  ? 179 PHE A CE1    1 
ATOM   2637 C CE2    . PHE A 1 179 ? 28.99800 -2.83000  11.14400  1.000 36.41000  ? 179 PHE A CE2    1 
ATOM   2638 C CZ     . PHE A 1 179 ? 28.57400 -2.15300  10.00700  1.000 32.73000  ? 179 PHE A CZ     1 
ATOM   2639 H H      . PHE A 1 179 ? 24.57600 -5.25100  10.09000  1.000 46.80000  ? 179 PHE A H      1 
ATOM   2640 H HA     . PHE A 1 179 ? 26.63500 -6.37400  11.42100  1.000 40.44000  ? 179 PHE A HA     1 
ATOM   2641 H HB2    . PHE A 1 179 ? 24.92900 -4.23600  12.11400  1.000 33.12000  ? 179 PHE A HB2    1 
ATOM   2642 H HB3    . PHE A 1 179 ? 26.11400 -4.73800  13.04700  1.000 33.12000  ? 179 PHE A HB3    1 
ATOM   2643 H HD1    . PHE A 1 179 ? 25.51000 -3.26500  9.88100   1.000 44.44000  ? 179 PHE A HD1    1 
ATOM   2644 H HD2    . PHE A 1 179 ? 28.35800 -4.05600  12.63700  1.000 38.86000  ? 179 PHE A HD2    1 
ATOM   2645 H HE1    . PHE A 1 179 ? 26.98600 -1.87600  8.75100   1.000 50.73000  ? 179 PHE A HE1    1 
ATOM   2646 H HE2    . PHE A 1 179 ? 29.88100 -2.76100  11.42700  1.000 44.07000  ? 179 PHE A HE2    1 
ATOM   2647 H HZ     . PHE A 1 179 ? 29.16300 -1.59000  9.55800   1.000 39.66000  ? 179 PHE A HZ     1 
ATOM   2648 N N      . LEU A 1 180 ? 25.33000 -8.25200  12.29800  1.000 35.79000  ? 180 LEU A N      1 
ATOM   2649 C CA     . LEU A 1 180 ? 24.51800 -9.32600  12.85100  1.000 38.99000  ? 180 LEU A CA     1 
ATOM   2650 C C      . LEU A 1 180 ? 24.32200 -9.19300  14.35200  1.000 38.46000  ? 180 LEU A C      1 
ATOM   2651 O O      . LEU A 1 180 ? 25.25200 -8.89200  15.09400  1.000 48.59000  ? 180 LEU A O      1 
ATOM   2652 C CB     . LEU A 1 180 ? 25.15600 -10.65600 12.54500  1.000 41.05000  ? 180 LEU A CB     1 
ATOM   2653 C CG     . LEU A 1 180 ? 25.16700 -11.05700 11.08100  1.000 34.13000  ? 180 LEU A CG     1 
ATOM   2654 C CD1    . LEU A 1 180 ? 25.84600 -12.42300 10.99300  1.000 42.69000  ? 180 LEU A CD1    1 
ATOM   2655 C CD2    . LEU A 1 180 ? 23.80800 -11.13500 10.46300  1.000 38.02000  ? 180 LEU A CD2    1 
ATOM   2656 H H      . LEU A 1 180 ? 26.08900 -8.50800  11.98400  1.000 43.32000  ? 180 LEU A H      1 
ATOM   2657 H HA     . LEU A 1 180 ? 23.64000 -9.28200  12.44200  1.000 47.17000  ? 180 LEU A HA     1 
ATOM   2658 H HB2    . LEU A 1 180 ? 26.07900 -10.62700 12.84300  1.000 49.64000  ? 180 LEU A HB2    1 
ATOM   2659 H HB3    . LEU A 1 180 ? 24.67300 -11.34400 13.02900  1.000 49.64000  ? 180 LEU A HB3    1 
ATOM   2660 H HG     . LEU A 1 180 ? 25.63900 -10.37600 10.57600  1.000 41.34000  ? 180 LEU A HG     1 
ATOM   2661 H HD11   . LEU A 1 180 ? 25.86100 -12.71000 10.06700  1.000 51.61000  ? 180 LEU A HD11   1 
ATOM   2662 H HD12   . LEU A 1 180 ? 26.75200 -12.34800 11.33100  1.000 51.61000  ? 180 LEU A HD12   1 
ATOM   2663 H HD13   . LEU A 1 180 ? 25.34500 -13.05900 11.52800  1.000 51.61000  ? 180 LEU A HD13   1 
ATOM   2664 H HD21   . LEU A 1 180 ? 23.90200 -11.34100 9.52000   1.000 46.01000  ? 180 LEU A HD21   1 
ATOM   2665 H HD22   . LEU A 1 180 ? 23.30000 -11.83200 10.90500  1.000 46.01000  ? 180 LEU A HD22   1 
ATOM   2666 H HD23   . LEU A 1 180 ? 23.36200 -10.28000 10.57200  1.000 46.01000  ? 180 LEU A HD23   1 
ATOM   2667 N N      . LYS A 1 181 ? 23.09500 -9.44200  14.79200  1.000 50.96000  ? 181 LYS A N      1 
ATOM   2668 C CA     . LYS A 1 181 ? 22.79600 -9.63100  16.20700  1.000 44.20000  ? 181 LYS A CA     1 
ATOM   2669 C C      . LYS A 1 181 ? 23.67700 -10.72400 16.81400  1.000 43.30000  ? 181 LYS A C      1 
ATOM   2670 O O      . LYS A 1 181 ? 24.08100 -11.67500 16.12800  1.000 51.00000  ? 181 LYS A O      1 
ATOM   2671 C CB     . LYS A 1 181 ? 21.31900 -10.00300 16.42700  1.000 41.09000  ? 181 LYS A CB     1 
ATOM   2672 C CG     . LYS A 1 181 ? 20.27900 -8.96400  16.09100  1.000 37.44000  ? 181 LYS A CG     1 
ATOM   2673 C CD     . LYS A 1 181 ? 18.94100 -9.65100  15.91500  1.000 43.10000  ? 181 LYS A CD     1 
ATOM   2674 C CE     . LYS A 1 181 ? 17.75600 -8.67700  15.68800  1.000 43.87000  ? 181 LYS A CE     1 
ATOM   2675 N NZ     . LYS A 1 181 ? 16.46700 -9.42400  15.50800  1.000 51.31000  ? 181 LYS A NZ     1 
ATOM   2676 H H      . LYS A 1 181 ? 22.40500 -9.50800  14.28300  1.000 61.54000  ? 181 LYS A H      1 
ATOM   2677 H HA     . LYS A 1 181 ? 22.97200 -8.79100  16.65800  1.000 53.43000  ? 181 LYS A HA     1 
ATOM   2678 H HB2    . LYS A 1 181 ? 21.12500 -10.78000 15.88000  1.000 49.69000  ? 181 LYS A HB2    1 
ATOM   2679 H HB3    . LYS A 1 181 ? 21.20500 -10.22100 17.36500  1.000 49.69000  ? 181 LYS A HB3    1 
ATOM   2680 H HG2    . LYS A 1 181 ? 20.21000 -8.31900  16.81200  1.000 45.31000  ? 181 LYS A HG2    1 
ATOM   2681 H HG3    . LYS A 1 181 ? 20.51500 -8.51400  15.26500  1.000 45.31000  ? 181 LYS A HG3    1 
ATOM   2682 H HD2    . LYS A 1 181 ? 18.99100 -10.23700 15.14400  1.000 52.10000  ? 181 LYS A HD2    1 
ATOM   2683 H HD3    . LYS A 1 181 ? 18.74800 -10.16800 16.71300  1.000 52.10000  ? 181 LYS A HD3    1 
ATOM   2684 H HE2    . LYS A 1 181 ? 17.66700 -8.09300  16.45800  1.000 53.02000  ? 181 LYS A HE2    1 
ATOM   2685 H HE3    . LYS A 1 181 ? 17.92000 -8.15100  14.89000  1.000 53.02000  ? 181 LYS A HE3    1 
ATOM   2686 H HZ1    . LYS A 1 181 ? 15.79100 -8.85100  15.43300  1.000 61.95000  ? 181 LYS A HZ1    1 
ATOM   2687 H HZ2    . LYS A 1 181 ? 16.50500 -9.92400  14.77300  1.000 61.95000  ? 181 LYS A HZ2    1 
ATOM   2688 H HZ3    . LYS A 1 181 ? 16.32100 -9.95300  16.21000  1.000 61.95000  ? 181 LYS A HZ3    1 
ATOM   2689 N N      . GLU A 1 182 ? 23.89900 -10.66100 18.11900  1.000 59.00000  ? 182 GLU A N      1 
ATOM   2690 C CA     . GLU A 1 182 ? 24.77600 -11.62100 18.76100  1.000 61.72000  ? 182 GLU A CA     1 
ATOM   2691 C C      . GLU A 1 182 ? 24.17600 -13.01700 18.86100  1.000 37.62000  ? 182 GLU A C      1 
ATOM   2692 O O      . GLU A 1 182 ? 24.92100 -13.96900 19.06100  1.000 39.95000  ? 182 GLU A O      1 
ATOM   2693 C CB     . GLU A 1 182 ? 25.12500 -11.17200 20.18400  1.000 62.78000  ? 182 GLU A CB     1 
ATOM   2694 C CG     . GLU A 1 182 ? 25.41200 -9.68100  20.33300  1.000 96.14000  ? 182 GLU A CG     1 
ATOM   2695 C CD     . GLU A 1 182 ? 24.10100 -8.86300  20.33800  1.000 101.01000 ? 182 GLU A CD     1 
ATOM   2696 O OE1    . GLU A 1 182 ? 23.08000 -9.29500  19.71300  1.000 97.11000  ? 182 GLU A OE1    1 
ATOM   2697 O OE2    . GLU A 1 182 ? 24.11400 -7.76000  20.91900  1.000 87.04000  ? 182 GLU A OE2    1 
ATOM   2698 H H      . GLU A 1 182 ? 23.55600 -10.07700 18.64900  1.000 71.19000  ? 182 GLU A H      1 
ATOM   2699 H HA     . GLU A 1 182 ? 25.58200 -11.65900 18.22300  1.000 74.45000  ? 182 GLU A HA     1 
ATOM   2700 H HB2    . GLU A 1 182 ? 24.37900 -11.38600 20.76600  1.000 75.72000  ? 182 GLU A HB2    1 
ATOM   2701 H HB3    . GLU A 1 182 ? 25.91800 -11.65200 20.47200  1.000 75.72000  ? 182 GLU A HB3    1 
ATOM   2702 H HG2    . GLU A 1 182 ? 25.87500 -9.52400  21.17100  1.000 115.75000 ? 182 GLU A HG2    1 
ATOM   2703 H HG3    . GLU A 1 182 ? 25.95900 -9.38200  19.59000  1.000 115.75000 ? 182 GLU A HG3    1 
ATOM   2704 N N      . ASP A 1 183 ? 22.87000 -13.17200 18.77900  1.000 43.95000  ? 183 ASP A N      1 
ATOM   2705 C CA     . ASP A 1 183 ? 22.30900 -14.52100 18.79400  1.000 47.27000  ? 183 ASP A CA     1 
ATOM   2706 C C      . ASP A 1 183 ? 22.34400 -15.18100 17.41800  1.000 59.90000  ? 183 ASP A C      1 
ATOM   2707 O O      . ASP A 1 183 ? 21.86400 -16.31400 17.28700  1.000 62.52000  ? 183 ASP A O      1 
ATOM   2708 C CB     . ASP A 1 183 ? 20.84000 -14.52000 19.31600  1.000 65.66000  ? 183 ASP A CB     1 
ATOM   2709 C CG     . ASP A 1 183 ? 19.93000 -13.45600 18.64200  1.000 63.03000  ? 183 ASP A CG     1 
ATOM   2710 O OD1    . ASP A 1 183 ? 20.08500 -12.24700 18.92300  1.000 75.93000  ? 183 ASP A OD1    1 
ATOM   2711 O OD2    . ASP A 1 183 ? 19.02500 -13.82300 17.85500  1.000 73.12000  ? 183 ASP A OD2    1 
ATOM   2712 H H      . ASP A 1 183 ? 22.29700 -12.53300 18.71600  1.000 53.12000  ? 183 ASP A H      1 
ATOM   2713 H HA     . ASP A 1 183 ? 22.83400 -15.05100 19.41400  1.000 57.11000  ? 183 ASP A HA     1 
ATOM   2714 H HB2    . ASP A 1 183 ? 20.44900 -15.39100 19.14700  1.000 79.18000  ? 183 ASP A HB2    1 
ATOM   2715 H HB3    . ASP A 1 183 ? 20.84800 -14.34000 20.26900  1.000 79.18000  ? 183 ASP A HB3    1 
ATOM   2716 N N      . GLN A 1 184 ? 22.87800 -14.49700 16.38000  1.000 52.75000  ? 184 GLN A N      1 
ATOM   2717 C CA     . GLN A 1 184 ? 22.62600 -14.90600 14.99700  1.000 47.61000  ? 184 GLN A CA     1 
ATOM   2718 C C      . GLN A 1 184 ? 23.91000 -15.07200 14.19700  1.000 40.75000  ? 184 GLN A C      1 
ATOM   2719 O O      . GLN A 1 184 ? 23.88400 -15.09400 12.96600  1.000 45.88000  ? 184 GLN A O      1 
ATOM   2720 C CB     . GLN A 1 184 ? 21.70400 -13.90800 14.28900  1.000 42.47000  ? 184 GLN A CB     1 
ATOM   2721 C CG     . GLN A 1 184 ? 20.36800 -13.66400 14.97700  1.000 53.68000  ? 184 GLN A CG     1 
ATOM   2722 C CD     . GLN A 1 184 ? 19.48500 -14.88700 14.89700  1.000 42.24000  ? 184 GLN A CD     1 
ATOM   2723 O OE1    . GLN A 1 184 ? 19.73500 -15.80700 14.10100  1.000 54.00000  ? 184 GLN A OE1    1 
ATOM   2724 N NE2    . GLN A 1 184 ? 18.41400 -14.88800 15.68900  1.000 47.82000  ? 184 GLN A NE2    1 
ATOM   2725 H H      . GLN A 1 184 ? 23.38200 -13.80400 16.46000  1.000 63.68000  ? 184 GLN A H      1 
ATOM   2726 H HA     . GLN A 1 184 ? 22.18200 -15.76800 15.02200  1.000 57.51000  ? 184 GLN A HA     1 
ATOM   2727 H HB2    . GLN A 1 184 ? 22.16200 -13.05400 14.23200  1.000 51.35000  ? 184 GLN A HB2    1 
ATOM   2728 H HB3    . GLN A 1 184 ? 21.51500 -14.24300 13.39800  1.000 51.35000  ? 184 GLN A HB3    1 
ATOM   2729 H HG2    . GLN A 1 184 ? 20.52000 -13.45600 15.91200  1.000 64.80000  ? 184 GLN A HG2    1 
ATOM   2730 H HG3    . GLN A 1 184 ? 19.91100 -12.92600 14.54300  1.000 64.80000  ? 184 GLN A HG3    1 
ATOM   2731 H HE21   . GLN A 1 184 ? 18.26000 -14.21700 16.20500  1.000 57.76000  ? 184 GLN A HE21   1 
ATOM   2732 H HE22   . GLN A 1 184 ? 17.87600 -15.55900 15.68400  1.000 57.76000  ? 184 GLN A HE22   1 
ATOM   2733 N N      . LEU A 1 185 ? 25.02800 -15.21500 14.87000  1.000 44.78000  ? 185 LEU A N      1 
ATOM   2734 C CA     . LEU A 1 185 ? 26.32100 -15.34800 14.22700  1.000 35.53000  ? 185 LEU A CA     1 
ATOM   2735 C C      . LEU A 1 185 ? 26.49300 -16.65200 13.46000  1.000 40.99000  ? 185 LEU A C      1 
ATOM   2736 O O      . LEU A 1 185 ? 27.51400 -16.83400 12.77400  1.000 50.32000  ? 185 LEU A O      1 
ATOM   2737 C CB     . LEU A 1 185 ? 27.41300 -15.19600 15.28500  1.000 46.28000  ? 185 LEU A CB     1 
ATOM   2738 C CG     . LEU A 1 185 ? 27.35600 -13.86100 16.01400  1.000 55.04000  ? 185 LEU A CG     1 
ATOM   2739 C CD1    . LEU A 1 185 ? 28.62800 -13.69100 16.85800  1.000 42.64000  ? 185 LEU A CD1    1 
ATOM   2740 C CD2    . LEU A 1 185 ? 27.19300 -12.69300 15.04000  1.000 58.24000  ? 185 LEU A CD2    1 
ATOM   2741 H H      . LEU A 1 185 ? 25.07100 -15.24000 15.72800  1.000 54.12000  ? 185 LEU A H      1 
ATOM   2742 H HA     . LEU A 1 185 ? 26.42500 -14.63800 13.57500  1.000 43.01000  ? 185 LEU A HA     1 
ATOM   2743 H HB2    . LEU A 1 185 ? 27.31400 -15.90200 15.94300  1.000 55.91000  ? 185 LEU A HB2    1 
ATOM   2744 H HB3    . LEU A 1 185 ? 28.27900 -15.26500 14.85300  1.000 55.91000  ? 185 LEU A HB3    1 
ATOM   2745 H HG     . LEU A 1 185 ? 26.58100 -13.84900 16.59700  1.000 66.43000  ? 185 LEU A HG     1 
ATOM   2746 H HD11   . LEU A 1 185 ? 28.60200 -12.82600 17.29700  1.000 51.55000  ? 185 LEU A HD11   1 
ATOM   2747 H HD12   . LEU A 1 185 ? 28.66400 -14.39800 17.52000  1.000 51.55000  ? 185 LEU A HD12   1 
ATOM   2748 H HD13   . LEU A 1 185 ? 29.40200 -13.74300 16.27600  1.000 51.55000  ? 185 LEU A HD13   1 
ATOM   2749 H HD21   . LEU A 1 185 ? 27.25000 -11.86000 15.53400  1.000 70.26000  ? 185 LEU A HD21   1 
ATOM   2750 H HD22   . LEU A 1 185 ? 27.89900 -12.73400 14.37600  1.000 70.26000  ? 185 LEU A HD22   1 
ATOM   2751 H HD23   . LEU A 1 185 ? 26.32700 -12.76100 14.60700  1.000 70.26000  ? 185 LEU A HD23   1 
ATOM   2752 N N      . GLU A 1 186 ? 25.51200 -17.54700 13.51500  1.000 43.59000  ? 186 GLU A N      1 
ATOM   2753 C CA     . GLU A 1 186 ? 25.62400 -18.74800 12.69600  1.000 41.60000  ? 186 GLU A CA     1 
ATOM   2754 C C      . GLU A 1 186 ? 25.69700 -18.41400 11.21100  1.000 52.42000  ? 186 GLU A C      1 
ATOM   2755 O O      . GLU A 1 186 ? 26.16100 -19.23400 10.41500  1.000 49.77000  ? 186 GLU A O      1 
ATOM   2756 C CB     . GLU A 1 186 ? 24.43000 -19.65500 12.96800  1.000 46.80000  ? 186 GLU A CB     1 
ATOM   2757 C CG     . GLU A 1 186 ? 23.13300 -19.08700 12.51700  1.000 49.19000  ? 186 GLU A CG     1 
ATOM   2758 C CD     . GLU A 1 186 ? 21.91900 -19.79500 13.18000  1.000 55.65000  ? 186 GLU A CD     1 
ATOM   2759 O OE1    . GLU A 1 186 ? 21.64900 -19.57200 14.39200  1.000 48.98000  ? 186 GLU A OE1    1 
ATOM   2760 O OE2    . GLU A 1 186 ? 21.24700 -20.56700 12.47200  1.000 43.53000  ? 186 GLU A OE2    1 
ATOM   2761 H H      . GLU A 1 186 ? 24.80200 -17.48600 13.99600  1.000 52.69000  ? 186 GLU A H      1 
ATOM   2762 H HA     . GLU A 1 186 ? 26.43300 -19.22800 12.93400  1.000 50.31000  ? 186 GLU A HA     1 
ATOM   2763 H HB2    . GLU A 1 186 ? 24.56400 -20.49500 12.50200  1.000 56.54000  ? 186 GLU A HB2    1 
ATOM   2764 H HB3    . GLU A 1 186 ? 24.36900 -19.81200 13.92300  1.000 56.54000  ? 186 GLU A HB3    1 
ATOM   2765 H HG2    . GLU A 1 186 ? 23.09900 -18.14700 12.75100  1.000 59.41000  ? 186 GLU A HG2    1 
ATOM   2766 H HG3    . GLU A 1 186 ? 23.05600 -19.19300 11.55600  1.000 59.41000  ? 186 GLU A HG3    1 
ATOM   2767 N N      . TYR A 1 187 ? 25.19600 -17.24900 10.81100  1.000 46.58000  ? 187 TYR A N      1 
ATOM   2768 C CA     . TYR A 1 187 ? 25.09100 -16.91500 9.39600   1.000 39.36000  ? 187 TYR A CA     1 
ATOM   2769 C C      . TYR A 1 187 ? 26.40400 -16.40400 8.82300   1.000 52.24000  ? 187 TYR A C      1 
ATOM   2770 O O      . TYR A 1 187 ? 26.47700 -16.10100 7.61900   1.000 34.19000  ? 187 TYR A O      1 
ATOM   2771 C CB     . TYR A 1 187 ? 23.99900 -15.88200 9.19000   1.000 39.52000  ? 187 TYR A CB     1 
ATOM   2772 C CG     . TYR A 1 187 ? 22.64900 -16.45300 9.51800   1.000 36.98000  ? 187 TYR A CG     1 
ATOM   2773 C CD1    . TYR A 1 187 ? 22.15400 -17.52100 8.78300   1.000 42.41000  ? 187 TYR A CD1    1 
ATOM   2774 C CD2    . TYR A 1 187 ? 21.88800 -15.95900 10.59800  1.000 39.98000  ? 187 TYR A CD2    1 
ATOM   2775 C CE1    . TYR A 1 187 ? 20.91900 -18.10400 9.10800   1.000 49.88000  ? 187 TYR A CE1    1 
ATOM   2776 C CE2    . TYR A 1 187 ? 20.67300 -16.50600 10.90900  1.000 37.63000  ? 187 TYR A CE2    1 
ATOM   2777 C CZ     . TYR A 1 187 ? 20.18900 -17.58900 10.17100  1.000 48.38000  ? 187 TYR A CZ     1 
ATOM   2778 O OH     . TYR A 1 187 ? 18.96800 -18.15000 10.44400  1.000 55.34000  ? 187 TYR A OH     1 
ATOM   2779 H H      . TYR A 1 187 ? 24.91100 -16.63500 11.34100  1.000 56.28000  ? 187 TYR A H      1 
ATOM   2780 H HA     . TYR A 1 187 ? 24.84000 -17.70900 8.90000   1.000 47.62000  ? 187 TYR A HA     1 
ATOM   2781 H HB2    . TYR A 1 187 ? 24.16000 -15.12200 9.77000   1.000 47.81000  ? 187 TYR A HB2    1 
ATOM   2782 H HB3    . TYR A 1 187 ? 23.99500 -15.59700 8.26300   1.000 47.81000  ? 187 TYR A HB3    1 
ATOM   2783 H HD1    . TYR A 1 187 ? 22.64600 -17.85300 8.06700   1.000 51.27000  ? 187 TYR A HD1    1 
ATOM   2784 H HD2    . TYR A 1 187 ? 22.21600 -15.25200 11.10600  1.000 48.36000  ? 187 TYR A HD2    1 
ATOM   2785 H HE1    . TYR A 1 187 ? 20.59500 -18.82500 8.61800   1.000 60.24000  ? 187 TYR A HE1    1 
ATOM   2786 H HE2    . TYR A 1 187 ? 20.17000 -16.15800 11.60900  1.000 45.53000  ? 187 TYR A HE2    1 
ATOM   2787 H HH     . TYR A 1 187 ? 18.65800 -17.83000 11.15700  1.000 66.79000  ? 187 TYR A HH     1 
ATOM   2788 N N      . LEU A 1 188 ? 27.43200 -16.33900 9.65200   1.000 36.21000  ? 188 LEU A N      1 
ATOM   2789 C CA     . LEU A 1 188 ? 28.79600 -16.17600 9.22200   1.000 44.51000  ? 188 LEU A CA     1 
ATOM   2790 C C      . LEU A 1 188 ? 29.49100 -17.47100 8.82700   1.000 46.41000  ? 188 LEU A C      1 
ATOM   2791 O O      . LEU A 1 188 ? 30.63600 -17.40300 8.36500   1.000 44.66000  ? 188 LEU A O      1 
ATOM   2792 C CB     . LEU A 1 188 ? 29.59700 -15.57200 10.35800  1.000 24.73000  ? 188 LEU A CB     1 
ATOM   2793 C CG     . LEU A 1 188 ? 29.17300 -14.17900 10.75300  1.000 34.63000  ? 188 LEU A CG     1 
ATOM   2794 C CD1    . LEU A 1 188 ? 29.89200 -13.83500 12.03100  1.000 34.97000  ? 188 LEU A CD1    1 
ATOM   2795 C CD2    . LEU A 1 188 ? 29.49600 -13.15900 9.69900   1.000 45.05000  ? 188 LEU A CD2    1 
ATOM   2796 H H      . LEU A 1 188 ? 27.35600 -16.39000 10.50700  1.000 43.84000  ? 188 LEU A H      1 
ATOM   2797 H HA     . LEU A 1 188 ? 28.78800 -15.59100 8.44800   1.000 53.80000  ? 188 LEU A HA     1 
ATOM   2798 H HB2    . LEU A 1 188 ? 29.50200 -16.14000 11.13800  1.000 30.06000  ? 188 LEU A HB2    1 
ATOM   2799 H HB3    . LEU A 1 188 ? 30.52800 -15.53000 10.09000  1.000 30.06000  ? 188 LEU A HB3    1 
ATOM   2800 H HG     . LEU A 1 188 ? 28.21000 -14.15400 10.86900  1.000 41.94000  ? 188 LEU A HG     1 
ATOM   2801 H HD11   . LEU A 1 188 ? 29.67600 -12.92200 12.27900  1.000 42.35000  ? 188 LEU A HD11   1 
ATOM   2802 H HD12   . LEU A 1 188 ? 29.60500 -14.44400 12.72900  1.000 42.35000  ? 188 LEU A HD12   1 
ATOM   2803 H HD13   . LEU A 1 188 ? 30.84800 -13.92100 11.88900  1.000 42.35000  ? 188 LEU A HD13   1 
ATOM   2804 H HD21   . LEU A 1 188 ? 29.19800 -12.28700 10.00100  1.000 54.45000  ? 188 LEU A HD21   1 
ATOM   2805 H HD22   . LEU A 1 188 ? 30.45500 -13.14800 9.55300   1.000 54.45000  ? 188 LEU A HD22   1 
ATOM   2806 H HD23   . LEU A 1 188 ? 29.04000 -13.39800 8.87700   1.000 54.45000  ? 188 LEU A HD23   1 
ATOM   2807 N N      . GLU A 1 189 ? 28.84300 -18.61400 8.96500   1.000 42.15000  ? 189 GLU A N      1 
ATOM   2808 C CA     . GLU A 1 189 ? 29.48300 -19.90900 8.78900   1.000 38.77000  ? 189 GLU A CA     1 
ATOM   2809 C C      . GLU A 1 189 ? 29.22900 -20.46500 7.38900   1.000 33.85000  ? 189 GLU A C      1 
ATOM   2810 O O      . GLU A 1 189 ? 28.08600 -20.54600 6.93300   1.000 41.55000  ? 189 GLU A O      1 
ATOM   2811 C CB     . GLU A 1 189 ? 28.97700 -20.90700 9.84800   1.000 44.93000  ? 189 GLU A CB     1 
ATOM   2812 C CG     . GLU A 1 189 ? 29.43500 -20.63100 11.29000  1.000 38.79000  ? 189 GLU A CG     1 
ATOM   2813 C CD     . GLU A 1 189 ? 30.94600 -20.71500 11.43100  1.000 51.20000  ? 189 GLU A CD     1 
ATOM   2814 O OE1    . GLU A 1 189 ? 31.59100 -21.35100 10.57500  1.000 60.54000  ? 189 GLU A OE1    1 
ATOM   2815 O OE2    . GLU A 1 189 ? 31.47900 -20.12900 12.39300  1.000 55.53000  ? 189 GLU A OE2    1 
ATOM   2816 H H      . GLU A 1 189 ? 28.00800 -18.66900 9.16500   1.000 50.96000  ? 189 GLU A H      1 
ATOM   2817 H HA     . GLU A 1 189 ? 30.44200 -19.79600 8.88600   1.000 46.91000  ? 189 GLU A HA     1 
ATOM   2818 H HB2    . GLU A 1 189 ? 28.00700 -20.88900 9.84500   1.000 54.29000  ? 189 GLU A HB2    1 
ATOM   2819 H HB3    . GLU A 1 189 ? 29.29400 -21.79200 9.60900   1.000 54.29000  ? 189 GLU A HB3    1 
ATOM   2820 H HG2    . GLU A 1 189 ? 29.15500 -19.74000 11.54900  1.000 46.93000  ? 189 GLU A HG2    1 
ATOM   2821 H HG3    . GLU A 1 189 ? 29.03800 -21.28900 11.88200  1.000 46.93000  ? 189 GLU A HG3    1 
ATOM   2822 N N      . GLU A 1 190 ? 30.30600 -20.87900 6.73700   1.000 36.07000  ? 190 GLU A N      1 
ATOM   2823 C CA     . GLU A 1 190 ? 30.25300 -21.43200 5.39500   1.000 38.07000  ? 190 GLU A CA     1 
ATOM   2824 C C      . GLU A 1 190 ? 29.22300 -22.55000 5.25700   1.000 49.11000  ? 190 GLU A C      1 
ATOM   2825 O O      . GLU A 1 190 ? 28.44400 -22.57100 4.29100   1.000 43.99000  ? 190 GLU A O      1 
ATOM   2826 C CB     . GLU A 1 190 ? 31.65500 -21.91100 5.00300   1.000 43.75000  ? 190 GLU A CB     1 
ATOM   2827 C CG     . GLU A 1 190 ? 31.68600 -22.80300 3.73800   1.000 55.76000  ? 190 GLU A CG     1 
ATOM   2828 C CD     . GLU A 1 190 ? 33.08300 -23.29200 3.33500   1.000 63.29000  ? 190 GLU A CD     1 
ATOM   2829 O OE1    . GLU A 1 190 ? 34.07900 -23.17400 4.12200   1.000 57.79000  ? 190 GLU A OE1    1 
ATOM   2830 O OE2    . GLU A 1 190 ? 33.17300 -23.76200 2.17500   1.000 52.70000  ? 190 GLU A OE2    1 
ATOM   2831 H H      . GLU A 1 190 ? 31.10300 -20.85000 7.05900   1.000 43.66000  ? 190 GLU A H      1 
ATOM   2832 H HA     . GLU A 1 190 ? 29.97400 -20.73500 4.78000   1.000 46.07000  ? 190 GLU A HA     1 
ATOM   2833 H HB2    . GLU A 1 190 ? 32.21100 -21.13600 4.83100   1.000 52.89000  ? 190 GLU A HB2    1 
ATOM   2834 H HB3    . GLU A 1 190 ? 32.02300 -22.42800 5.73700   1.000 52.89000  ? 190 GLU A HB3    1 
ATOM   2835 H HG2    . GLU A 1 190 ? 31.13800 -23.58600 3.89900   1.000 67.29000  ? 190 GLU A HG2    1 
ATOM   2836 H HG3    . GLU A 1 190 ? 31.32900 -22.29500 2.99300   1.000 67.29000  ? 190 GLU A HG3    1 
ATOM   2837 N N      . LYS A 1 191 ? 29.22000 -23.51600 6.17800   1.000 46.22000  ? 191 LYS A N      1 
ATOM   2838 C CA     . LYS A 1 191 ? 28.22400 -24.58800 6.07700   1.000 53.92000  ? 191 LYS A CA     1 
ATOM   2839 C C      . LYS A 1 191 ? 26.79900 -24.03300 6.19500   1.000 54.41000  ? 191 LYS A C      1 
ATOM   2840 O O      . LYS A 1 191 ? 25.93100 -24.31800 5.36300   1.000 46.77000  ? 191 LYS A O      1 
ATOM   2841 C CB     . LYS A 1 191 ? 28.46000 -25.64300 7.15300   1.000 56.11000  ? 191 LYS A CB     1 
ATOM   2842 C CG     . LYS A 1 191 ? 27.86300 -27.00900 6.83600   1.000 76.41000  ? 191 LYS A CG     1 
ATOM   2843 C CD     . LYS A 1 191 ? 28.82400 -27.88400 6.00700   1.000 88.03000  ? 191 LYS A CD     1 
ATOM   2844 C CE     . LYS A 1 191 ? 29.85300 -28.60500 6.90700   1.000 90.58000  ? 191 LYS A CE     1 
ATOM   2845 N NZ     . LYS A 1 191 ? 29.20000 -29.52900 7.88900   1.000 102.90000 ? 191 LYS A NZ     1 
ATOM   2846 H H      . LYS A 1 191 ? 29.76100 -23.57300 6.84500   1.000 55.84000  ? 191 LYS A H      1 
ATOM   2847 H HA     . LYS A 1 191 ? 28.32300 -25.01000 5.21000   1.000 65.08000  ? 191 LYS A HA     1 
ATOM   2848 H HB2    . LYS A 1 191 ? 29.41600 -25.75900 7.26700   1.000 67.72000  ? 191 LYS A HB2    1 
ATOM   2849 H HB3    . LYS A 1 191 ? 28.06200 -25.33400 7.98200   1.000 67.72000  ? 191 LYS A HB3    1 
ATOM   2850 H HG2    . LYS A 1 191 ? 27.67100 -27.47300 7.66600   1.000 92.07000  ? 191 LYS A HG2    1 
ATOM   2851 H HG3    . LYS A 1 191 ? 27.04700 -26.89000 6.32600   1.000 92.07000  ? 191 LYS A HG3    1 
ATOM   2852 H HD2    . LYS A 1 191 ? 28.31500 -28.55600 5.52700   1.000 106.01000 ? 191 LYS A HD2    1 
ATOM   2853 H HD3    . LYS A 1 191 ? 29.30800 -27.32400 5.38000   1.000 106.01000 ? 191 LYS A HD3    1 
ATOM   2854 H HE2    . LYS A 1 191 ? 30.45000 -29.12800 6.35000   1.000 109.07000 ? 191 LYS A HE2    1 
ATOM   2855 H HE3    . LYS A 1 191 ? 30.35800 -27.94300 7.40500   1.000 109.07000 ? 191 LYS A HE3    1 
ATOM   2856 H HZ1    . LYS A 1 191 ? 29.82000 -29.94200 8.37600   1.000 123.86000 ? 191 LYS A HZ1    1 
ATOM   2857 H HZ2    . LYS A 1 191 ? 28.66500 -29.06900 8.43100   1.000 123.86000 ? 191 LYS A HZ2    1 
ATOM   2858 H HZ3    . LYS A 1 191 ? 28.71800 -30.14000 7.45700   1.000 123.86000 ? 191 LYS A HZ3    1 
ATOM   2859 N N      . ARG A 1 192 ? 26.53700 -23.23900 7.23400   1.000 45.70000  ? 192 ARG A N      1 
ATOM   2860 C CA     . ARG A 1 192 ? 25.20700 -22.67900 7.41100   1.000 44.92000  ? 192 ARG A CA     1 
ATOM   2861 C C      . ARG A 1 192 ? 24.76700 -21.93400 6.15400   1.000 53.07000  ? 192 ARG A C      1 
ATOM   2862 O O      . ARG A 1 192 ? 23.67400 -22.14700 5.62800   1.000 45.30000  ? 192 ARG A O      1 
ATOM   2863 C CB     . ARG A 1 192 ? 25.19800 -21.76700 8.63600   1.000 40.88000  ? 192 ARG A CB     1 
ATOM   2864 C CG     . ARG A 1 192 ? 23.82800 -21.28000 9.00100   1.000 49.59000  ? 192 ARG A CG     1 
ATOM   2865 C CD     . ARG A 1 192 ? 22.80900 -22.39700 9.18000   1.000 49.13000  ? 192 ARG A CD     1 
ATOM   2866 N NE     . ARG A 1 192 ? 21.64100 -21.82700 9.83600   1.000 48.88000  ? 192 ARG A NE     1 
ATOM   2867 C CZ     . ARG A 1 192 ? 20.38600 -22.07200 9.48200   1.000 39.43000  ? 192 ARG A CZ     1 
ATOM   2868 N NH1    . ARG A 1 192 ? 20.09900 -23.00400 8.60700   1.000 36.98000  ? 192 ARG A NH1    1 
ATOM   2869 N NH2    . ARG A 1 192 ? 19.39800 -21.31300 9.97700   1.000 58.19000  ? 192 ARG A NH2    1 
ATOM   2870 H H      . ARG A 1 192 ? 27.10600 -23.01500 7.83900   1.000 55.23000  ? 192 ARG A H      1 
ATOM   2871 H HA     . ARG A 1 192 ? 24.56900 -23.39200 7.56900   1.000 54.28000  ? 192 ARG A HA     1 
ATOM   2872 H HB2    . ARG A 1 192 ? 25.55200 -22.25700 9.39400   1.000 49.44000  ? 192 ARG A HB2    1 
ATOM   2873 H HB3    . ARG A 1 192 ? 25.75100 -20.99100 8.45400   1.000 49.44000  ? 192 ARG A HB3    1 
ATOM   2874 H HG2    . ARG A 1 192 ? 23.88200 -20.79200 9.83700   1.000 59.89000  ? 192 ARG A HG2    1 
ATOM   2875 H HG3    . ARG A 1 192 ? 23.50600 -20.69600 8.29600   1.000 59.89000  ? 192 ARG A HG3    1 
ATOM   2876 H HD2    . ARG A 1 192 ? 22.54900 -22.75700 8.31700   1.000 59.34000  ? 192 ARG A HD2    1 
ATOM   2877 H HD3    . ARG A 1 192 ? 23.17700 -23.10200 9.73600   1.000 59.34000  ? 192 ARG A HD3    1 
ATOM   2878 H HE     . ARG A 1 192 ? 21.77300 -21.29400 10.49800  1.000 59.04000  ? 192 ARG A HE     1 
ATOM   2879 H HH11   . ARG A 1 192 ? 20.73000 -23.46800 8.25100   1.000 44.76000  ? 192 ARG A HH11   1 
ATOM   2880 H HH12   . ARG A 1 192 ? 19.28100 -23.15100 8.38800   1.000 44.76000  ? 192 ARG A HH12   1 
ATOM   2881 H HH21   . ARG A 1 192 ? 19.58000 -20.67100 10.52000  1.000 70.21000  ? 192 ARG A HH21   1 
ATOM   2882 H HH22   . ARG A 1 192 ? 18.58300 -21.46700 9.75100   1.000 70.21000  ? 192 ARG A HH22   1 
ATOM   2883 N N      . ILE A 1 193 ? 25.61500 -21.06600 5.64800   1.000 45.95000  ? 193 ILE A N      1 
ATOM   2884 C CA     . ILE A 1 193 ? 25.22300 -20.28100 4.49500   1.000 51.82000  ? 193 ILE A CA     1 
ATOM   2885 C C      . ILE A 1 193 ? 24.93100 -21.19500 3.30700   1.000 43.65000  ? 193 ILE A C      1 
ATOM   2886 O O      . ILE A 1 193 ? 23.99100 -20.96400 2.52800   1.000 43.08000  ? 193 ILE A O      1 
ATOM   2887 C CB     . ILE A 1 193 ? 26.31800 -19.24800 4.19300   1.000 46.94000  ? 193 ILE A CB     1 
ATOM   2888 C CG1    . ILE A 1 193 ? 26.45100 -18.24700 5.34600   1.000 41.14000  ? 193 ILE A CG1    1 
ATOM   2889 C CG2    . ILE A 1 193 ? 26.01100 -18.52300 2.92300   1.000 42.81000  ? 193 ILE A CG2    1 
ATOM   2890 C CD1    . ILE A 1 193 ? 27.74400 -17.43900 5.22000   1.000 40.47000  ? 193 ILE A CD1    1 
ATOM   2891 H H      . ILE A 1 193 ? 26.40800 -20.91400 5.94500   1.000 55.53000  ? 193 ILE A H      1 
ATOM   2892 H HA     . ILE A 1 193 ? 24.40300 -19.80100 4.68700   1.000 62.56000  ? 193 ILE A HA     1 
ATOM   2893 H HB     . ILE A 1 193 ? 27.15900 -19.72100 4.09500   1.000 56.71000  ? 193 ILE A HB     1 
ATOM   2894 H HG12   . ILE A 1 193 ? 25.70100 -17.63200 5.32900   1.000 49.75000  ? 193 ILE A HG12   1 
ATOM   2895 H HG13   . ILE A 1 193 ? 26.46800 -18.72600 6.19000   1.000 49.75000  ? 193 ILE A HG13   1 
ATOM   2896 H HG21   . ILE A 1 193 ? 26.52800 -17.70300 2.89500   1.000 51.75000  ? 193 ILE A HG21   1 
ATOM   2897 H HG22   . ILE A 1 193 ? 26.24700 -19.08900 2.17200   1.000 51.75000  ? 193 ILE A HG22   1 
ATOM   2898 H HG23   . ILE A 1 193 ? 25.06300 -18.31800 2.89800   1.000 51.75000  ? 193 ILE A HG23   1 
ATOM   2899 H HD11   . ILE A 1 193 ? 28.16400 -17.37700 6.09200   1.000 48.95000  ? 193 ILE A HD11   1 
ATOM   2900 H HD12   . ILE A 1 193 ? 28.33700 -17.88800 4.59700   1.000 48.95000  ? 193 ILE A HD12   1 
ATOM   2901 H HD13   . ILE A 1 193 ? 27.53100 -16.55100 4.89200   1.000 48.95000  ? 193 ILE A HD13   1 
ATOM   2902 N N      . LYS A 1 194 ? 25.69600 -22.26700 3.16700   1.000 51.73000  ? 194 LYS A N      1 
ATOM   2903 C CA     . LYS A 1 194 ? 25.42400 -23.18700 2.07000   1.000 57.07000  ? 194 LYS A CA     1 
ATOM   2904 C C      . LYS A 1 194 ? 24.01900 -23.79900 2.16200   1.000 51.42000  ? 194 LYS A C      1 
ATOM   2905 O O      . LYS A 1 194 ? 23.32600 -23.91700 1.14500   1.000 49.57000  ? 194 LYS A O      1 
ATOM   2906 C CB     . LYS A 1 194 ? 26.49200 -24.28300 2.02700   1.000 62.07000  ? 194 LYS A CB     1 
ATOM   2907 C CG     . LYS A 1 194 ? 27.67900 -24.00900 1.09400   1.000 56.69000  ? 194 LYS A CG     1 
ATOM   2908 C CD     . LYS A 1 194 ? 28.62000 -25.21200 1.03600   1.000 67.39000  ? 194 LYS A CD     1 
ATOM   2909 C CE     . LYS A 1 194 ? 30.07900 -24.84300 1.27300   1.000 67.68000  ? 194 LYS A CE     1 
ATOM   2910 N NZ     . LYS A 1 194 ? 30.87700 -24.80000 0.01000   1.000 88.06000  ? 194 LYS A NZ     1 
ATOM   2911 H H      . LYS A 1 194 ? 26.35600 -22.48000 3.67500   1.000 62.46000  ? 194 LYS A H      1 
ATOM   2912 H HA     . LYS A 1 194 ? 25.46600 -22.68900 1.23800   1.000 68.87000  ? 194 LYS A HA     1 
ATOM   2913 H HB2    . LYS A 1 194 ? 26.84800 -24.39800 2.92200   1.000 74.87000  ? 194 LYS A HB2    1 
ATOM   2914 H HB3    . LYS A 1 194 ? 26.07300 -25.10600 1.72900   1.000 74.87000  ? 194 LYS A HB3    1 
ATOM   2915 H HG2    . LYS A 1 194 ? 27.35100 -23.83200 0.19800   1.000 68.41000  ? 194 LYS A HG2    1 
ATOM   2916 H HG3    . LYS A 1 194 ? 28.17800 -23.24500 1.42200   1.000 68.41000  ? 194 LYS A HG3    1 
ATOM   2917 H HD2    . LYS A 1 194 ? 28.35900 -25.84900 1.71900   1.000 81.25000  ? 194 LYS A HD2    1 
ATOM   2918 H HD3    . LYS A 1 194 ? 28.55500 -25.62100 0.15900   1.000 81.25000  ? 194 LYS A HD3    1 
ATOM   2919 H HE2    . LYS A 1 194 ? 30.12100 -23.96500 1.68400   1.000 81.60000  ? 194 LYS A HE2    1 
ATOM   2920 H HE3    . LYS A 1 194 ? 30.48100 -25.50300 1.85900   1.000 81.60000  ? 194 LYS A HE3    1 
ATOM   2921 H HZ1    . LYS A 1 194 ? 31.71400 -24.55500 0.18600   1.000 106.06000 ? 194 LYS A HZ1    1 
ATOM   2922 H HZ2    . LYS A 1 194 ? 30.88600 -25.60400 -0.37200  1.000 106.06000 ? 194 LYS A HZ2    1 
ATOM   2923 H HZ3    . LYS A 1 194 ? 30.51800 -24.21600 -0.55700  1.000 106.06000 ? 194 LYS A HZ3    1 
ATOM   2924 N N      . GLU A 1 195 ? 23.58400 -24.18800 3.36100   1.000 44.54000  ? 195 GLU A N      1 
ATOM   2925 C CA     . GLU A 1 195 ? 22.28900 -24.83700 3.50800   1.000 48.92000  ? 195 GLU A CA     1 
ATOM   2926 C C      . GLU A 1 195 ? 21.16200 -23.91300 3.07100   1.000 45.59000  ? 195 GLU A C      1 
ATOM   2927 O O      . GLU A 1 195 ? 20.22800 -24.31900 2.39400   1.000 42.63000  ? 195 GLU A O      1 
ATOM   2928 C CB     . GLU A 1 195 ? 22.06900 -25.23100 4.97100   1.000 60.54000  ? 195 GLU A CB     1 
ATOM   2929 C CG     . GLU A 1 195 ? 22.88800 -26.35400 5.50100   1.000 62.22000  ? 195 GLU A CG     1 
ATOM   2930 C CD     . GLU A 1 195 ? 22.66400 -26.55000 6.99800   1.000 82.85000  ? 195 GLU A CD     1 
ATOM   2931 O OE1    . GLU A 1 195 ? 22.20000 -25.59900 7.67200   1.000 77.20000  ? 195 GLU A OE1    1 
ATOM   2932 O OE2    . GLU A 1 195 ? 22.94700 -27.65400 7.49100   1.000 78.48000  ? 195 GLU A OE2    1 
ATOM   2933 H H      . GLU A 1 195 ? 24.01800 -24.08700 4.09700   1.000 53.83000  ? 195 GLU A H      1 
ATOM   2934 H HA     . GLU A 1 195 ? 22.28300 -25.63300 2.95500   1.000 59.09000  ? 195 GLU A HA     1 
ATOM   2935 H HB2    . GLU A 1 195 ? 22.26300 -24.45600 5.52200   1.000 73.03000  ? 195 GLU A HB2    1 
ATOM   2936 H HB3    . GLU A 1 195 ? 21.13900 -25.48700 5.07500   1.000 73.03000  ? 195 GLU A HB3    1 
ATOM   2937 H HG2    . GLU A 1 195 ? 22.64200 -27.17400 5.04500   1.000 75.05000  ? 195 GLU A HG2    1 
ATOM   2938 H HG3    . GLU A 1 195 ? 23.82800 -26.16200 5.35500   1.000 75.05000  ? 195 GLU A HG3    1 
ATOM   2939 N N      . VAL A 1 196 ? 21.19400 -22.67700 3.53000   1.000 46.78000  ? 196 VAL A N      1 
ATOM   2940 C CA     . VAL A 1 196 ? 20.06200 -21.78800 3.32100   1.000 45.04000  ? 196 VAL A CA     1 
ATOM   2941 C C      . VAL A 1 196 ? 19.92800 -21.46400 1.84500   1.000 47.24000  ? 196 VAL A C      1 
ATOM   2942 O O      . VAL A 1 196 ? 18.82500 -21.44600 1.29100   1.000 44.19000  ? 196 VAL A O      1 
ATOM   2943 C CB     . VAL A 1 196 ? 20.24300 -20.53700 4.20200   1.000 42.27000  ? 196 VAL A CB     1 
ATOM   2944 C CG1    . VAL A 1 196 ? 19.13900 -19.57000 3.99300   1.000 43.49000  ? 196 VAL A CG1    1 
ATOM   2945 C CG2    . VAL A 1 196 ? 20.37900 -20.97300 5.71100   1.000 39.58000  ? 196 VAL A CG2    1 
ATOM   2946 H H      . VAL A 1 196 ? 21.85000 -22.32900 3.96300   1.000 56.51000  ? 196 VAL A H      1 
ATOM   2947 H HA     . VAL A 1 196 ? 19.23700 -22.22000 3.59000   1.000 54.43000  ? 196 VAL A HA     1 
ATOM   2948 H HB     . VAL A 1 196 ? 21.05700 -20.07500 3.94900   1.000 51.11000  ? 196 VAL A HB     1 
ATOM   2949 H HG11   . VAL A 1 196 ? 19.23300 -18.84200 4.62800   1.000 52.57000  ? 196 VAL A HG11   1 
ATOM   2950 H HG12   . VAL A 1 196 ? 19.18600 -19.22700 3.08700   1.000 52.57000  ? 196 VAL A HG12   1 
ATOM   2951 H HG13   . VAL A 1 196 ? 18.29200 -20.02300 4.13200   1.000 52.57000  ? 196 VAL A HG13   1 
ATOM   2952 H HG21   . VAL A 1 196 ? 20.50500 -20.18100 6.25700   1.000 47.87000  ? 196 VAL A HG21   1 
ATOM   2953 H HG22   . VAL A 1 196 ? 19.57000 -21.43500 5.98000   1.000 47.87000  ? 196 VAL A HG22   1 
ATOM   2954 H HG23   . VAL A 1 196 ? 21.14300 -21.56300 5.80100   1.000 47.87000  ? 196 VAL A HG23   1 
ATOM   2955 N N      . VAL A 1 197 ? 21.04500 -21.26200 1.16300   1.000 39.63000  ? 197 VAL A N      1 
ATOM   2956 C CA     . VAL A 1 197 ? 20.97600 -20.90400 -0.25400  1.000 42.96000  ? 197 VAL A CA     1 
ATOM   2957 C C      . VAL A 1 197 ? 20.38400 -22.04300 -1.06800  1.000 61.67000  ? 197 VAL A C      1 
ATOM   2958 O O      . VAL A 1 197 ? 19.44200 -21.83900 -1.84800  1.000 64.19000  ? 197 VAL A O      1 
ATOM   2959 C CB     . VAL A 1 197 ? 22.36800 -20.51200 -0.77200  1.000 37.85000  ? 197 VAL A CB     1 
ATOM   2960 C CG1    . VAL A 1 197 ? 22.41000 -20.44800 -2.29700  1.000 38.79000  ? 197 VAL A CG1    1 
ATOM   2961 C CG2    . VAL A 1 197 ? 22.79300 -19.15600 -0.16800  1.000 44.25000  ? 197 VAL A CG2    1 
ATOM   2962 H H      . VAL A 1 197 ? 21.84000 -21.32200 1.48500   1.000 47.94000  ? 197 VAL A H      1 
ATOM   2963 H HA     . VAL A 1 197 ? 20.38800 -20.13800 -0.34600  1.000 51.94000  ? 197 VAL A HA     1 
ATOM   2964 H HB     . VAL A 1 197 ? 22.99700 -21.19600 -0.49600  1.000 45.80000  ? 197 VAL A HB     1 
ATOM   2965 H HG11   . VAL A 1 197 ? 23.14700 -19.88000 -2.56900  1.000 46.93000  ? 197 VAL A HG11   1 
ATOM   2966 H HG12   . VAL A 1 197 ? 22.53700 -21.34400 -2.64700  1.000 46.93000  ? 197 VAL A HG12   1 
ATOM   2967 H HG13   . VAL A 1 197 ? 21.57300 -20.08200 -2.62100  1.000 46.93000  ? 197 VAL A HG13   1 
ATOM   2968 H HG21   . VAL A 1 197 ? 23.66700 -18.91600 -0.51400  1.000 53.48000  ? 197 VAL A HG21   1 
ATOM   2969 H HG22   . VAL A 1 197 ? 22.14200 -18.48100 -0.41700  1.000 53.48000  ? 197 VAL A HG22   1 
ATOM   2970 H HG23   . VAL A 1 197 ? 22.83100 -19.23800 0.79800   1.000 53.48000  ? 197 VAL A HG23   1 
ATOM   2971 N N      . LYS A 1 198 ? 20.93600 -23.26100 -0.90800  1.000 60.62000  ? 198 LYS A N      1 
ATOM   2972 C CA     . LYS A 1 198 ? 20.46200 -24.39700 -1.70200  1.000 73.38000  ? 198 LYS A CA     1 
ATOM   2973 C C      . LYS A 1 198 ? 19.02100 -24.75500 -1.35200  1.000 67.37000  ? 198 LYS A C      1 
ATOM   2974 O O      . LYS A 1 198 ? 18.25000 -25.19600 -2.21800  1.000 64.98000  ? 198 LYS A O      1 
ATOM   2975 C CB     . LYS A 1 198 ? 21.37900 -25.59500 -1.49400  1.000 57.01000  ? 198 LYS A CB     1 
ATOM   2976 C CG     . LYS A 1 198 ? 22.83300 -25.38300 -1.97900  1.000 74.98000  ? 198 LYS A CG     1 
ATOM   2977 C CD     . LYS A 1 198 ? 23.67800 -26.66100 -1.85800  1.000 75.15000  ? 198 LYS A CD     1 
ATOM   2978 C CE     . LYS A 1 198 ? 24.61200 -26.62200 -0.63300  1.000 94.80000  ? 198 LYS A CE     1 
ATOM   2979 N NZ     . LYS A 1 198 ? 25.39300 -27.88800 -0.36400  1.000 94.43000  ? 198 LYS A NZ     1 
ATOM   2980 H H      . LYS A 1 198 ? 21.57100 -23.44700 -0.35900  1.000 73.13000  ? 198 LYS A H      1 
ATOM   2981 H HA     . LYS A 1 198 ? 20.49100 -24.16300 -2.64300  1.000 88.44000  ? 198 LYS A HA     1 
ATOM   2982 H HB2    . LYS A 1 198 ? 21.41400 -25.79600 -0.54600  1.000 68.80000  ? 198 LYS A HB2    1 
ATOM   2983 H HB3    . LYS A 1 198 ? 21.01500 -26.35100 -1.98000  1.000 68.80000  ? 198 LYS A HB3    1 
ATOM   2984 H HG2    . LYS A 1 198 ? 22.82100 -25.11600 -2.91200  1.000 90.36000  ? 198 LYS A HG2    1 
ATOM   2985 H HG3    . LYS A 1 198 ? 23.25100 -24.69200 -1.44200  1.000 90.36000  ? 198 LYS A HG3    1 
ATOM   2986 H HD2    . LYS A 1 198 ? 23.08900 -27.42600 -1.76600  1.000 90.57000  ? 198 LYS A HD2    1 
ATOM   2987 H HD3    . LYS A 1 198 ? 24.22600 -26.75700 -2.65300  1.000 90.57000  ? 198 LYS A HD3    1 
ATOM   2988 H HE2    . LYS A 1 198 ? 25.25700 -25.90900 -0.76300  1.000 114.14000 ? 198 LYS A HE2    1 
ATOM   2989 H HE3    . LYS A 1 198 ? 24.07400 -26.44400 0.15500   1.000 114.14000 ? 198 LYS A HE3    1 
ATOM   2990 H HZ1    . LYS A 1 198 ? 25.89300 -27.78800 0.36500   1.000 113.70000 ? 198 LYS A HZ1    1 
ATOM   2991 H HZ2    . LYS A 1 198 ? 24.83400 -28.56900 -0.24000  1.000 113.70000 ? 198 LYS A HZ2    1 
ATOM   2992 H HZ3    . LYS A 1 198 ? 25.92300 -28.07100 -1.05500  1.000 113.70000 ? 198 LYS A HZ3    1 
ATOM   2993 N N      . LYS A 1 199 ? 18.63400 -24.47800 -0.11300  1.000 46.22000  ? 199 LYS A N      1 
ATOM   2994 C CA     . LYS A 1 199 ? 17.28600 -24.71300 0.36000   1.000 55.16000  ? 199 LYS A CA     1 
ATOM   2995 C C      . LYS A 1 199 ? 16.29000 -23.74100 -0.24300  1.000 63.16000  ? 199 LYS A C      1 
ATOM   2996 O O      . LYS A 1 199 ? 15.15900 -24.12100 -0.57200  1.000 64.06000  ? 199 LYS A O      1 
ATOM   2997 C CB     . LYS A 1 199 ? 17.28200 -24.57900 1.87700   1.000 61.03000  ? 199 LYS A CB     1 
ATOM   2998 C CG     . LYS A 1 199 ? 15.97100 -24.79500 2.53500   1.000 76.48000  ? 199 LYS A CG     1 
ATOM   2999 C CD     . LYS A 1 199 ? 16.05200 -24.35800 3.98800   1.000 97.24000  ? 199 LYS A CD     1 
ATOM   3000 C CE     . LYS A 1 199 ? 15.26600 -25.30800 4.89900   1.000 110.51000 ? 199 LYS A CE     1 
ATOM   3001 N NZ     . LYS A 1 199 ? 14.86200 -24.65600 6.19900   1.000 97.88000  ? 199 LYS A NZ     1 
ATOM   3002 H H      . LYS A 1 199 ? 19.15000 -24.14300 0.48800   1.000 55.84000  ? 199 LYS A H      1 
ATOM   3003 H HA     . LYS A 1 199 ? 17.01200 -25.60700 0.10000   1.000 66.57000  ? 199 LYS A HA     1 
ATOM   3004 H HB2    . LYS A 1 199 ? 17.90000 -25.23200 2.24200   1.000 73.62000  ? 199 LYS A HB2    1 
ATOM   3005 H HB3    . LYS A 1 199 ? 17.57500 -23.68200 2.10400   1.000 73.62000  ? 199 LYS A HB3    1 
ATOM   3006 H HG2    . LYS A 1 199 ? 15.28900 -24.27100 2.08800   1.000 92.16000  ? 199 LYS A HG2    1 
ATOM   3007 H HG3    . LYS A 1 199 ? 15.74000 -25.73700 2.50400   1.000 92.16000  ? 199 LYS A HG3    1 
ATOM   3008 H HD2    . LYS A 1 199 ? 16.97900 -24.35800 4.27300   1.000 117.07000 ? 199 LYS A HD2    1 
ATOM   3009 H HD3    . LYS A 1 199 ? 15.67700 -23.46800 4.07800   1.000 117.07000 ? 199 LYS A HD3    1 
ATOM   3010 H HE2    . LYS A 1 199 ? 14.46000 -25.59300 4.44200   1.000 132.99000 ? 199 LYS A HE2    1 
ATOM   3011 H HE3    . LYS A 1 199 ? 15.81800 -26.07800 5.10800   1.000 132.99000 ? 199 LYS A HE3    1 
ATOM   3012 H HZ1    . LYS A 1 199 ? 14.39700 -25.22900 6.69600   1.000 117.84000 ? 199 LYS A HZ1    1 
ATOM   3013 H HZ2    . LYS A 1 199 ? 15.58600 -24.40400 6.65100   1.000 117.84000 ? 199 LYS A HZ2    1 
ATOM   3014 H HZ3    . LYS A 1 199 ? 14.35900 -23.94000 6.03700   1.000 117.84000 ? 199 LYS A HZ3    1 
ATOM   3015 N N      . HIS A 1 200 ? 16.64300 -22.46200 -0.31100  1.000 62.93000  ? 200 HIS A N      1 
ATOM   3016 C CA     . HIS A 1 200 ? 15.63100 -21.44300 -0.56200  1.000 47.15000  ? 200 HIS A CA     1 
ATOM   3017 C C      . HIS A 1 200 ? 15.81100 -20.73000 -1.87600  1.000 45.82000  ? 200 HIS A C      1 
ATOM   3018 O O      . HIS A 1 200 ? 14.88400 -20.04300 -2.31000  1.000 46.19000  ? 200 HIS A O      1 
ATOM   3019 C CB     . HIS A 1 200 ? 15.62000 -20.39900 0.54900   1.000 64.16000  ? 200 HIS A CB     1 
ATOM   3020 C CG     . HIS A 1 200 ? 15.04600 -20.88900 1.83800   1.000 70.85000  ? 200 HIS A CG     1 
ATOM   3021 N ND1    . HIS A 1 200 ? 13.71700 -21.20800 1.97900   1.000 64.39000  ? 200 HIS A ND1    1 
ATOM   3022 C CD2    . HIS A 1 200 ? 15.61400 -21.09200 3.05000   1.000 73.15000  ? 200 HIS A CD2    1 
ATOM   3023 C CE1    . HIS A 1 200 ? 13.49100 -21.60200 3.21600   1.000 67.62000  ? 200 HIS A CE1    1 
ATOM   3024 N NE2    . HIS A 1 200 ? 14.61700 -21.50800 3.89600   1.000 76.13000  ? 200 HIS A NE2    1 
ATOM   3025 H H      . HIS A 1 200 ? 17.44600 -22.16600 -0.21800  1.000 75.90000  ? 200 HIS A H      1 
ATOM   3026 H HA     . HIS A 1 200 ? 14.76700 -21.88400 -0.56600  1.000 56.97000  ? 200 HIS A HA     1 
ATOM   3027 H HB2    . HIS A 1 200 ? 16.53200 -20.11700 0.72000   1.000 77.37000  ? 200 HIS A HB2    1 
ATOM   3028 H HB3    . HIS A 1 200 ? 15.08700 -19.64200 0.25900   1.000 77.37000  ? 200 HIS A HB3    1 
ATOM   3029 H HD1    . HIS A 1 200 ? 13.12500 -21.15700 1.35700   1.000 77.64000  ? 200 HIS A HD1    1 
ATOM   3030 H HD2    . HIS A 1 200 ? 16.51000 -20.97200 3.26700   1.000 88.16000  ? 200 HIS A HD2    1 
ATOM   3031 H HE1    . HIS A 1 200 ? 12.67600 -21.89800 3.55200   1.000 81.53000  ? 200 HIS A HE1    1 
ATOM   3032 H HE2    . HIS A 1 200 ? 14.71100 -21.67800 4.73400   1.000 91.73000  ? 200 HIS A HE2    1 
ATOM   3033 N N      . SER A 1 201 ? 16.95600 -20.89600 -2.53500  1.000 46.24000  ? 201 SER A N      1 
ATOM   3034 C CA     . SER A 1 201 ? 17.28500 -20.11100 -3.72700  1.000 50.21000  ? 201 SER A CA     1 
ATOM   3035 C C      . SER A 1 201 ? 17.79100 -20.99800 -4.87600  1.000 60.32000  ? 201 SER A C      1 
ATOM   3036 O O      . SER A 1 201 ? 18.78300 -20.69100 -5.54100  1.000 55.98000  ? 201 SER A O      1 
ATOM   3037 C CB     . SER A 1 201 ? 18.35200 -19.05700 -3.40600  1.000 59.46000  ? 201 SER A CB     1 
ATOM   3038 O OG     . SER A 1 201 ? 18.01000 -18.26000 -2.31600  1.000 41.21000  ? 201 SER A OG     1 
ATOM   3039 H H      . SER A 1 201 ? 17.56300 -21.46300 -2.30900  1.000 55.87000  ? 201 SER A H      1 
ATOM   3040 H HA     . SER A 1 201 ? 16.46500 -19.68300 -4.01800  1.000 60.63000  ? 201 SER A HA     1 
ATOM   3041 H HB2    . SER A 1 201 ? 19.18400 -19.51300 -3.20600  1.000 71.74000  ? 201 SER A HB2    1 
ATOM   3042 H HB3    . SER A 1 201 ? 18.46400 -18.48700 -4.18300  1.000 71.74000  ? 201 SER A HB3    1 
ATOM   3043 H HG     . SER A 1 201 ? 17.40300 -17.72200 -2.53300  1.000 49.83000  ? 201 SER A HG     1 
ATOM   3044 N N      . GLU A 1 202 ? 17.08800 -22.09600 -5.15300  1.000 53.59000  ? 202 GLU A N      1 
ATOM   3045 C CA     . GLU A 1 202 ? 17.52200 -23.01000 -6.20900  1.000 53.55000  ? 202 GLU A CA     1 
ATOM   3046 C C      . GLU A 1 202 ? 17.36200 -22.41900 -7.61900  1.000 63.82000  ? 202 GLU A C      1 
ATOM   3047 O O      . GLU A 1 202 ? 18.07200 -22.83400 -8.54100  1.000 71.69000  ? 202 GLU A O      1 
ATOM   3048 C CB     . GLU A 1 202 ? 16.73500 -24.33100 -6.12700  1.000 50.49000  ? 202 GLU A CB     1 
ATOM   3049 H H      . GLU A 1 202 ? 16.36700 -22.33300 -4.75000  1.000 64.68000  ? 202 GLU A H      1 
ATOM   3050 H HA     . GLU A 1 202 ? 18.46500 -23.18800 -6.06400  1.000 64.64000  ? 202 GLU A HA     1 
ATOM   3051 N N      . PHE A 1 203 ? 16.43700 -21.48400 -7.83100  1.000 58.05000  ? 203 PHE A N      1 
ATOM   3052 C CA     . PHE A 1 203 ? 16.11300 -21.02600 -9.17900  1.000 41.56000  ? 203 PHE A CA     1 
ATOM   3053 C C      . PHE A 1 203 ? 16.47400 -19.55900 -9.33400  1.000 42.36000  ? 203 PHE A C      1 
ATOM   3054 O O      . PHE A 1 203 ? 15.62700 -18.67500 -9.41400  1.000 42.72000  ? 203 PHE A O      1 
ATOM   3055 C CB     . PHE A 1 203 ? 14.65600 -21.25700 -9.50200  1.000 44.06000  ? 203 PHE A CB     1 
ATOM   3056 C CG     . PHE A 1 203 ? 14.30100 -22.70000 -9.50300  1.000 46.81000  ? 203 PHE A CG     1 
ATOM   3057 C CD1    . PHE A 1 203 ? 14.70500 -23.50500 -10.56200 1.000 58.33000  ? 203 PHE A CD1    1 
ATOM   3058 C CD2    . PHE A 1 203 ? 13.66000 -23.27100 -8.42400  1.000 46.04000  ? 203 PHE A CD2    1 
ATOM   3059 C CE1    . PHE A 1 203 ? 14.42000 -24.86700 -10.57200 1.000 53.59000  ? 203 PHE A CE1    1 
ATOM   3060 C CE2    . PHE A 1 203 ? 13.35500 -24.62900 -8.41100  1.000 53.86000  ? 203 PHE A CE2    1 
ATOM   3061 C CZ     . PHE A 1 203 ? 13.74600 -25.43800 -9.48600  1.000 61.90000  ? 203 PHE A CZ     1 
ATOM   3062 H H      . PHE A 1 203 ? 15.98400 -21.10100 -7.20800  1.000 70.04000  ? 203 PHE A H      1 
ATOM   3063 H HA     . PHE A 1 203 ? 16.66500 -21.53700 -9.79200  1.000 50.25000  ? 203 PHE A HA     1 
ATOM   3064 H HB2    . PHE A 1 203 ? 14.10900 -20.81100 -8.83700  1.000 53.25000  ? 203 PHE A HB2    1 
ATOM   3065 H HB3    . PHE A 1 203 ? 14.46600 -20.89800 -10.38300 1.000 53.25000  ? 203 PHE A HB3    1 
ATOM   3066 H HD1    . PHE A 1 203 ? 15.17100 -23.12800 -11.27300 1.000 70.38000  ? 203 PHE A HD1    1 
ATOM   3067 H HD2    . PHE A 1 203 ? 13.42900 -22.74100 -7.69600  1.000 55.63000  ? 203 PHE A HD2    1 
ATOM   3068 H HE1    . PHE A 1 203 ? 14.67500 -25.39300 -11.29400 1.000 64.69000  ? 203 PHE A HE1    1 
ATOM   3069 H HE2    . PHE A 1 203 ? 12.89400 -24.99700 -7.69200  1.000 65.02000  ? 203 PHE A HE2    1 
ATOM   3070 H HZ     . PHE A 1 203 ? 13.55900 -26.34900 -9.47800  1.000 74.66000  ? 203 PHE A HZ     1 
ATOM   3071 N N      . VAL A 1 204 ? 17.76300 -19.31800 -9.46900  1.000 40.71000  ? 204 VAL A N      1 
ATOM   3072 C CA     . VAL A 1 204 ? 18.32300 -17.99400 -9.55900  1.000 43.25000  ? 204 VAL A CA     1 
ATOM   3073 C C      . VAL A 1 204 ? 19.12500 -17.95100 -10.83400 1.000 47.51000  ? 204 VAL A C      1 
ATOM   3074 O O      . VAL A 1 204 ? 19.99400 -18.79100 -11.03700 1.000 37.03000  ? 204 VAL A O      1 
ATOM   3075 C CB     . VAL A 1 204 ? 19.18100 -17.70300 -8.32400  1.000 41.01000  ? 204 VAL A CB     1 
ATOM   3076 C CG1    . VAL A 1 204 ? 19.94600 -16.44800 -8.46600  1.000 34.97000  ? 204 VAL A CG1    1 
ATOM   3077 C CG2    . VAL A 1 204 ? 18.21800 -17.64000 -7.10200  1.000 54.87000  ? 204 VAL A CG2    1 
ATOM   3078 H H      . VAL A 1 204 ? 18.35800 -19.93800 -9.51200  1.000 49.23000  ? 204 VAL A H      1 
ATOM   3079 H HA     . VAL A 1 204 ? 17.63900 -17.31000 -9.62100  1.000 52.28000  ? 204 VAL A HA     1 
ATOM   3080 H HB     . VAL A 1 204 ? 19.84400 -18.40100 -8.20100  1.000 49.59000  ? 204 VAL A HB     1 
ATOM   3081 H HG11   . VAL A 1 204 ? 20.33800 -16.21900 -7.60900  1.000 42.35000  ? 204 VAL A HG11   1 
ATOM   3082 H HG12   . VAL A 1 204 ? 20.64400 -16.57700 -9.12600  1.000 42.35000  ? 204 VAL A HG12   1 
ATOM   3083 H HG13   . VAL A 1 204 ? 19.34500 -15.74300 -8.75300  1.000 42.35000  ? 204 VAL A HG13   1 
ATOM   3084 H HG21   . VAL A 1 204 ? 18.72400 -17.38200 -6.31500  1.000 66.23000  ? 204 VAL A HG21   1 
ATOM   3085 H HG22   . VAL A 1 204 ? 17.52600 -16.98400 -7.28000  1.000 66.23000  ? 204 VAL A HG22   1 
ATOM   3086 H HG23   . VAL A 1 204 ? 17.82000 -18.51400 -6.96800  1.000 66.23000  ? 204 VAL A HG23   1 
ATOM   3087 N N      . ALA A 1 205 ? 18.82800 -16.99900 -11.70200 1.000 49.79000  ? 205 ALA A N      1 
ATOM   3088 C CA     . ALA A 1 205 ? 19.48600 -17.02800 -13.00100 1.000 46.15000  ? 205 ALA A CA     1 
ATOM   3089 C C      . ALA A 1 205 ? 20.97600 -16.73700 -12.92300 1.000 52.54000  ? 205 ALA A C      1 
ATOM   3090 O O      . ALA A 1 205 ? 21.63200 -16.83500 -13.95500 1.000 42.55000  ? 205 ALA A O      1 
ATOM   3091 C CB     . ALA A 1 205 ? 18.80200 -16.02200 -13.93700 1.000 47.03000  ? 205 ALA A CB     1 
ATOM   3092 H H      . ALA A 1 205 ? 18.27400 -16.35500 -11.57200 1.000 60.13000  ? 205 ALA A H      1 
ATOM   3093 H HA     . ALA A 1 205 ? 19.39100 -17.91400 -13.38200 1.000 55.77000  ? 205 ALA A HA     1 
ATOM   3094 H HB1    . ALA A 1 205 ? 19.26800 -16.01500 -14.78800 1.000 56.82000  ? 205 ALA A HB1    1 
ATOM   3095 H HB2    . ALA A 1 205 ? 17.87900 -16.28900 -14.06800 1.000 56.82000  ? 205 ALA A HB2    1 
ATOM   3096 H HB3    . ALA A 1 205 ? 18.83800 -15.14000 -13.53400 1.000 56.82000  ? 205 ALA A HB3    1 
ATOM   3097 N N      . TYR A 1 206 ? 21.52300 -16.41200 -11.74400 1.000 41.38000  ? 206 TYR A N      1 
ATOM   3098 C CA     . TYR A 1 206 ? 22.89400 -15.89800 -11.67500 1.000 39.89000  ? 206 TYR A CA     1 
ATOM   3099 C C      . TYR A 1 206 ? 23.73700 -16.62100 -10.63100 1.000 38.44000  ? 206 TYR A C      1 
ATOM   3100 O O      . TYR A 1 206 ? 23.21700 -17.17700 -9.66000  1.000 39.93000  ? 206 TYR A O      1 
ATOM   3101 C CB     . TYR A 1 206 ? 22.93800 -14.39600 -11.37300 1.000 27.85000  ? 206 TYR A CB     1 
ATOM   3102 C CG     . TYR A 1 206 ? 21.94300 -13.56800 -12.18300 1.000 41.99000  ? 206 TYR A CG     1 
ATOM   3103 C CD1    . TYR A 1 206 ? 22.25900 -13.10300 -13.44900 1.000 44.37000  ? 206 TYR A CD1    1 
ATOM   3104 C CD2    . TYR A 1 206 ? 20.69100 -13.24300 -11.67100 1.000 32.95000  ? 206 TYR A CD2    1 
ATOM   3105 C CE1    . TYR A 1 206 ? 21.34500 -12.33200 -14.17900 1.000 47.64000  ? 206 TYR A CE1    1 
ATOM   3106 C CE2    . TYR A 1 206 ? 19.80700 -12.48400 -12.38200 1.000 51.29000  ? 206 TYR A CE2    1 
ATOM   3107 C CZ     . TYR A 1 206 ? 20.14000 -12.03700 -13.63700 1.000 44.35000  ? 206 TYR A CZ     1 
ATOM   3108 O OH     . TYR A 1 206 ? 19.21700 -11.28700 -14.31200 1.000 45.23000  ? 206 TYR A OH     1 
ATOM   3109 H H      . TYR A 1 206 ? 21.12500 -16.47900 -10.98400 1.000 50.04000  ? 206 TYR A H      1 
ATOM   3110 H HA     . TYR A 1 206 ? 23.29400 -16.06200 -12.54400 1.000 48.25000  ? 206 TYR A HA     1 
ATOM   3111 H HB2    . TYR A 1 206 ? 22.73700 -14.26200 -10.43300 1.000 33.80000  ? 206 TYR A HB2    1 
ATOM   3112 H HB3    . TYR A 1 206 ? 23.82800 -14.06500 -11.57200 1.000 33.80000  ? 206 TYR A HB3    1 
ATOM   3113 H HD1    . TYR A 1 206 ? 23.08800 -13.30400 -13.81800 1.000 53.63000  ? 206 TYR A HD1    1 
ATOM   3114 H HD2    . TYR A 1 206 ? 20.45100 -13.55000 -10.82700 1.000 39.92000  ? 206 TYR A HD2    1 
ATOM   3115 H HE1    . TYR A 1 206 ? 21.56400 -12.02600 -15.02900 1.000 57.54000  ? 206 TYR A HE1    1 
ATOM   3116 H HE2    . TYR A 1 206 ? 18.97900 -12.27000 -12.01600 1.000 61.92000  ? 206 TYR A HE2    1 
ATOM   3117 H HH     . TYR A 1 206 ? 18.45100 -11.42400 -13.99800 1.000 54.65000  ? 206 TYR A HH     1 
ATOM   3118 N N      . PRO A 1 207 ? 25.04100 -16.67900 -10.85500 1.000 38.30000  ? 207 PRO A N      1 
ATOM   3119 C CA     . PRO A 1 207 ? 25.88400 -17.46100 -9.94000  1.000 41.16000  ? 207 PRO A CA     1 
ATOM   3120 C C      . PRO A 1 207 ? 25.88800 -16.79100 -8.58200  1.000 36.53000  ? 207 PRO A C      1 
ATOM   3121 O O      . PRO A 1 207 ? 26.07800 -15.57700 -8.48600  1.000 36.90000  ? 207 PRO A O      1 
ATOM   3122 C CB     . PRO A 1 207 ? 27.27300 -17.43200 -10.59500 1.000 40.75000  ? 207 PRO A CB     1 
ATOM   3123 C CG     . PRO A 1 207 ? 27.26900 -16.25000 -11.51100 1.000 37.31000  ? 207 PRO A CG     1 
ATOM   3124 C CD     . PRO A 1 207 ? 25.81600 -15.97200 -11.92000 1.000 38.27000  ? 207 PRO A CD     1 
ATOM   3125 H HA     . PRO A 1 207 ? 25.58900 -18.38300 -9.87500  1.000 49.77000  ? 207 PRO A HA     1 
ATOM   3126 H HB2    . PRO A 1 207 ? 27.95400 -17.33400 -9.91100  1.000 49.28000  ? 207 PRO A HB2    1 
ATOM   3127 H HB3    . PRO A 1 207 ? 27.41700 -18.25200 -11.09200 1.000 49.28000  ? 207 PRO A HB3    1 
ATOM   3128 H HG2    . PRO A 1 207 ? 27.63900 -15.48400 -11.04500 1.000 45.15000  ? 207 PRO A HG2    1 
ATOM   3129 H HG3    . PRO A 1 207 ? 27.80500 -16.45200 -12.29400 1.000 45.15000  ? 207 PRO A HG3    1 
ATOM   3130 H HD2    . PRO A 1 207 ? 25.62800 -15.02100 -11.91400 1.000 46.30000  ? 207 PRO A HD2    1 
ATOM   3131 H HD3    . PRO A 1 207 ? 25.62300 -16.34300 -12.79600 1.000 46.30000  ? 207 PRO A HD3    1 
ATOM   3132 N N      . ILE A 1 208 ? 25.65000 -17.58500 -7.54600  1.000 34.01000  ? 208 ILE A N      1 
ATOM   3133 C CA     . ILE A 1 208 ? 25.74800 -17.16100 -6.16300  1.000 40.68000  ? 208 ILE A CA     1 
ATOM   3134 C C      . ILE A 1 208 ? 27.10500 -17.59200 -5.63700  1.000 33.12000  ? 208 ILE A C      1 
ATOM   3135 O O      . ILE A 1 208 ? 27.35400 -18.78000 -5.41600  1.000 41.27000  ? 208 ILE A O      1 
ATOM   3136 C CB     . ILE A 1 208 ? 24.61700 -17.74400 -5.31400  1.000 47.73000  ? 208 ILE A CB     1 
ATOM   3137 C CG1    . ILE A 1 208 ? 23.27600 -17.23200 -5.81800  1.000 39.98000  ? 208 ILE A CG1    1 
ATOM   3138 C CG2    . ILE A 1 208 ? 24.84400 -17.38200 -3.83400  1.000 44.74000  ? 208 ILE A CG2    1 
ATOM   3139 C CD1    . ILE A 1 208 ? 22.08800 -17.99400 -5.28500  1.000 41.29000  ? 208 ILE A CD1    1 
ATOM   3140 H H      . ILE A 1 208 ? 25.42000 -18.41000 -7.62700  1.000 41.19000  ? 208 ILE A H      1 
ATOM   3141 H HA     . ILE A 1 208 ? 25.69700 -16.19300 -6.12400  1.000 49.20000  ? 208 ILE A HA     1 
ATOM   3142 H HB     . ILE A 1 208 ? 24.61300 -18.71100 -5.39300  1.000 57.66000  ? 208 ILE A HB     1 
ATOM   3143 H HG12   . ILE A 1 208 ? 23.17700 -16.30500 -5.55100  1.000 48.36000  ? 208 ILE A HG12   1 
ATOM   3144 H HG13   . ILE A 1 208 ? 23.26100 -17.30200 -6.78600  1.000 48.36000  ? 208 ILE A HG13   1 
ATOM   3145 H HG21   . ILE A 1 208 ? 24.09700 -17.71300 -3.31000  1.000 54.07000  ? 208 ILE A HG21   1 
ATOM   3146 H HG22   . ILE A 1 208 ? 25.66800 -17.79400 -3.53100  1.000 54.07000  ? 208 ILE A HG22   1 
ATOM   3147 H HG23   . ILE A 1 208 ? 24.90500 -16.41800 -3.75100  1.000 54.07000  ? 208 ILE A HG23   1 
ATOM   3148 H HD11   . ILE A 1 208 ? 21.28200 -17.66000 -5.71000  1.000 49.93000  ? 208 ILE A HD11   1 
ATOM   3149 H HD12   . ILE A 1 208 ? 22.20100 -18.93600 -5.48300  1.000 49.93000  ? 208 ILE A HD12   1 
ATOM   3150 H HD13   . ILE A 1 208 ? 22.03300 -17.86200 -4.32500  1.000 49.93000  ? 208 ILE A HD13   1 
ATOM   3151 N N      . GLN A 1 209 ? 27.95500 -16.61300 -5.38600  1.000 31.40000  ? 209 GLN A N      1 
ATOM   3152 C CA     . GLN A 1 209 ? 29.32400 -16.83800 -4.92500  1.000 49.45000  ? 209 GLN A CA     1 
ATOM   3153 C C      . GLN A 1 209 ? 29.44700 -16.62100 -3.42900  1.000 36.03000  ? 209 GLN A C      1 
ATOM   3154 O O      . GLN A 1 209 ? 28.96500 -15.61900 -2.89300  1.000 50.01000  ? 209 GLN A O      1 
ATOM   3155 C CB     . GLN A 1 209 ? 30.30000 -15.90800 -5.64900  1.000 32.67000  ? 209 GLN A CB     1 
ATOM   3156 C CG     . GLN A 1 209 ? 30.31300 -16.13100 -7.13600  1.000 34.67000  ? 209 GLN A CG     1 
ATOM   3157 C CD     . GLN A 1 209 ? 30.88500 -14.97500 -7.86800  1.000 32.60000  ? 209 GLN A CD     1 
ATOM   3158 O OE1    . GLN A 1 209 ? 31.16500 -13.92900 -7.29600  1.000 58.87000  ? 209 GLN A OE1    1 
ATOM   3159 N NE2    . GLN A 1 209 ? 31.04500 -15.14100 -9.13500  1.000 40.49000  ? 209 GLN A NE2    1 
ATOM   3160 H H      . GLN A 1 209 ? 27.76100 -15.78000 -5.47600  1.000 38.06000  ? 209 GLN A H      1 
ATOM   3161 H HA     . GLN A 1 209 ? 29.55300 -17.76200 -5.11100  1.000 59.72000  ? 209 GLN A HA     1 
ATOM   3162 H HB2    . GLN A 1 209 ? 30.04100 -14.98800 -5.48400  1.000 39.58000  ? 209 GLN A HB2    1 
ATOM   3163 H HB3    . GLN A 1 209 ? 31.19600 -16.06500 -5.31200  1.000 39.58000  ? 209 GLN A HB3    1 
ATOM   3164 H HG2    . GLN A 1 209 ? 30.85200 -16.91300 -7.33600  1.000 41.98000  ? 209 GLN A HG2    1 
ATOM   3165 H HG3    . GLN A 1 209 ? 29.40400 -16.26700 -7.44600  1.000 41.98000  ? 209 GLN A HG3    1 
ATOM   3166 H HE21   . GLN A 1 209 ? 30.82500 -15.88600 -9.50300  1.000 48.96000  ? 209 GLN A HE21   1 
ATOM   3167 H HE22   . GLN A 1 209 ? 31.37200 -14.50500 -9.61300  1.000 48.96000  ? 209 GLN A HE22   1 
ATOM   3168 N N      . LEU A 1 210 ? 30.09600 -17.56500 -2.77600  1.000 38.60000  ? 210 LEU A N      1 
ATOM   3169 C CA     . LEU A 1 210 ? 30.40100 -17.50200 -1.36000  1.000 34.90000  ? 210 LEU A CA     1 
ATOM   3170 C C      . LEU A 1 210 ? 31.90200 -17.32300 -1.19900  1.000 39.72000  ? 210 LEU A C      1 
ATOM   3171 O O      . LEU A 1 210 ? 32.68700 -17.97300 -1.89400  1.000 37.63000  ? 210 LEU A O      1 
ATOM   3172 C CB     . LEU A 1 210 ? 29.91600 -18.74800 -0.66000  1.000 37.02000  ? 210 LEU A CB     1 
ATOM   3173 C CG     . LEU A 1 210 ? 30.20600 -18.71000 0.85100   1.000 49.29000  ? 210 LEU A CG     1 
ATOM   3174 C CD1    . LEU A 1 210 ? 29.62100 -17.56600 1.60300   1.000 41.99000  ? 210 LEU A CD1    1 
ATOM   3175 C CD2    . LEU A 1 210 ? 29.70000 -20.07100 1.43000   1.000 53.39000  ? 210 LEU A CD2    1 
ATOM   3176 H H      . LEU A 1 210 ? 30.38300 -18.28500 -3.14800  1.000 46.70000  ? 210 LEU A H      1 
ATOM   3177 H HA     . LEU A 1 210 ? 29.96100 -16.74800 -0.93800  1.000 42.27000  ? 210 LEU A HA     1 
ATOM   3178 H HB2    . LEU A 1 210 ? 28.95800 -18.83100 -0.78400  1.000 44.81000  ? 210 LEU A HB2    1 
ATOM   3179 H HB3    . LEU A 1 210 ? 30.36700 -19.52000 -1.03700  1.000 44.81000  ? 210 LEU A HB3    1 
ATOM   3180 H HG     . LEU A 1 210 ? 31.15900 -18.57700 0.97400   1.000 59.53000  ? 210 LEU A HG     1 
ATOM   3181 H HD11   . LEU A 1 210 ? 29.95300 -17.58400 2.51400   1.000 50.77000  ? 210 LEU A HD11   1 
ATOM   3182 H HD12   . LEU A 1 210 ? 29.88200 -16.73800 1.17200   1.000 50.77000  ? 210 LEU A HD12   1 
ATOM   3183 H HD13   . LEU A 1 210 ? 28.65400 -17.64900 1.60200   1.000 50.77000  ? 210 LEU A HD13   1 
ATOM   3184 H HD21   . LEU A 1 210 ? 29.81500 -20.06600 2.39300   1.000 64.45000  ? 210 LEU A HD21   1 
ATOM   3185 H HD22   . LEU A 1 210 ? 28.76200 -20.17800 1.21000   1.000 64.45000  ? 210 LEU A HD22   1 
ATOM   3186 H HD23   . LEU A 1 210 ? 30.21700 -20.79200 1.03900   1.000 64.45000  ? 210 LEU A HD23   1 
ATOM   3187 N N      . VAL A 1 211 ? 32.31200 -16.38700 -0.34800  1.000 41.73000  ? 211 VAL A N      1 
ATOM   3188 C CA     . VAL A 1 211 ? 33.72600 -16.04600 -0.18000  1.000 38.07000  ? 211 VAL A CA     1 
ATOM   3189 C C      . VAL A 1 211 ? 34.19000 -16.61600 1.14400   1.000 40.99000  ? 211 VAL A C      1 
ATOM   3190 O O      . VAL A 1 211 ? 33.67900 -16.22700 2.19100   1.000 48.46000  ? 211 VAL A O      1 
ATOM   3191 C CB     . VAL A 1 211 ? 33.93600 -14.53000 -0.22000  1.000 51.86000  ? 211 VAL A CB     1 
ATOM   3192 C CG1    . VAL A 1 211 ? 35.31900 -14.20700 0.26000   1.000 36.16000  ? 211 VAL A CG1    1 
ATOM   3193 C CG2    . VAL A 1 211 ? 33.70100 -14.00500 -1.60600  1.000 35.93000  ? 211 VAL A CG2    1 
ATOM   3194 H H      . VAL A 1 211 ? 31.78400 -15.92900 0.15200   1.000 50.45000  ? 211 VAL A H      1 
ATOM   3195 H HA     . VAL A 1 211 ? 34.24400 -16.45500 -0.89100  1.000 46.07000  ? 211 VAL A HA     1 
ATOM   3196 H HB     . VAL A 1 211 ? 33.29900 -14.09100 0.36500   1.000 62.62000  ? 211 VAL A HB     1 
ATOM   3197 H HG11   . VAL A 1 211 ? 35.66300 -13.45700 -0.24900  1.000 43.78000  ? 211 VAL A HG11   1 
ATOM   3198 H HG12   . VAL A 1 211 ? 35.28100 -13.97800 1.20200   1.000 43.78000  ? 211 VAL A HG12   1 
ATOM   3199 H HG13   . VAL A 1 211 ? 35.88700 -14.98300 0.13100   1.000 43.78000  ? 211 VAL A HG13   1 
ATOM   3200 H HG21   . VAL A 1 211 ? 34.03900 -13.09800 -1.66200  1.000 43.50000  ? 211 VAL A HG21   1 
ATOM   3201 H HG22   . VAL A 1 211 ? 34.16700 -14.57100 -2.24100  1.000 43.50000  ? 211 VAL A HG22   1 
ATOM   3202 H HG23   . VAL A 1 211 ? 32.74900 -14.01500 -1.79000  1.000 43.50000  ? 211 VAL A HG23   1 
ATOM   3203 N N      . VAL A 1 212 ? 35.14400 -17.53400 1.10400   1.000 51.10000  ? 212 VAL A N      1 
ATOM   3204 C CA     . VAL A 1 212 ? 35.62600 -18.20100 2.30800   1.000 70.56000  ? 212 VAL A CA     1 
ATOM   3205 C C      . VAL A 1 212 ? 37.10600 -17.88800 2.50500   1.000 48.45000  ? 212 VAL A C      1 
ATOM   3206 O O      . VAL A 1 212 ? 37.92700 -18.04500 1.59000   1.000 37.12000  ? 212 VAL A O      1 
ATOM   3207 C CB     . VAL A 1 212 ? 35.40200 -19.72800 2.27000   1.000 68.95000  ? 212 VAL A CB     1 
ATOM   3208 C CG1    . VAL A 1 212 ? 33.98700 -20.08300 1.81900   1.000 72.01000  ? 212 VAL A CG1    1 
ATOM   3209 C CG2    . VAL A 1 212 ? 36.38400 -20.39300 1.35300   1.000 63.92000  ? 212 VAL A CG2    1 
ATOM   3210 H H      . VAL A 1 212 ? 35.53400 -17.79200 0.38200   1.000 61.70000  ? 212 VAL A H      1 
ATOM   3211 H HA     . VAL A 1 212 ? 35.13600 -17.83800 3.06200   1.000 85.06000  ? 212 VAL A HA     1 
ATOM   3212 H HB     . VAL A 1 212 ? 35.53000 -20.05600 3.17400   1.000 83.12000  ? 212 VAL A HB     1 
ATOM   3213 H HG11   . VAL A 1 212 ? 33.82400 -21.02200 1.99900   1.000 86.79000  ? 212 VAL A HG11   1 
ATOM   3214 H HG12   . VAL A 1 212 ? 33.35300 -19.53700 2.31000   1.000 86.79000  ? 212 VAL A HG12   1 
ATOM   3215 H HG13   . VAL A 1 212 ? 33.90500 -19.90900 0.86800   1.000 86.79000  ? 212 VAL A HG13   1 
ATOM   3216 H HG21   . VAL A 1 212 ? 36.14100 -21.32700 1.25400   1.000 77.09000  ? 212 VAL A HG21   1 
ATOM   3217 H HG22   . VAL A 1 212 ? 36.36000 -19.95100 0.49000   1.000 77.09000  ? 212 VAL A HG22   1 
ATOM   3218 H HG23   . VAL A 1 212 ? 37.27200 -20.32200 1.73600   1.000 77.09000  ? 212 VAL A HG23   1 
ATOM   3219 N N      . THR A 1 213 ? 37.43200 -17.40200 3.68200   1.000 50.06000  ? 213 THR A N      1 
ATOM   3220 C CA     . THR A 1 213 ? 38.80500 -17.26200 4.09200   1.000 46.01000  ? 213 THR A CA     1 
ATOM   3221 C C      . THR A 1 213 ? 39.23400 -18.56900 4.74700   1.000 61.35000  ? 213 THR A C      1 
ATOM   3222 O O      . THR A 1 213 ? 38.72200 -18.92300 5.80500   1.000 63.96000  ? 213 THR A O      1 
ATOM   3223 C CB     . THR A 1 213 ? 38.93800 -16.07100 5.02600   1.000 46.94000  ? 213 THR A CB     1 
ATOM   3224 O OG1    . THR A 1 213 ? 38.46400 -14.88900 4.38200   1.000 48.62000  ? 213 THR A OG1    1 
ATOM   3225 C CG2    . THR A 1 213 ? 40.40800 -15.85000 5.38100   1.000 58.09000  ? 213 THR A CG2    1 
ATOM   3226 H H      . THR A 1 213 ? 36.86300 -17.14100 4.27200   1.000 60.45000  ? 213 THR A H      1 
ATOM   3227 H HA     . THR A 1 213 ? 39.38500 -17.11100 3.32900   1.000 55.59000  ? 213 THR A HA     1 
ATOM   3228 H HB     . THR A 1 213 ? 38.42200 -16.24100 5.83000   1.000 56.71000  ? 213 THR A HB     1 
ATOM   3229 H HG1    . THR A 1 213 ? 38.59500 -14.22100 4.87400   1.000 58.72000  ? 213 THR A HG1    1 
ATOM   3230 H HG21   . THR A 1 213 ? 40.49600 -15.07500 5.95900   1.000 70.10000  ? 213 THR A HG21   1 
ATOM   3231 H HG22   . THR A 1 213 ? 40.75800 -16.62800 5.84200   1.000 70.10000  ? 213 THR A HG22   1 
ATOM   3232 H HG23   . THR A 1 213 ? 40.92500 -15.70200 4.57500   1.000 70.10000  ? 213 THR A HG23   1 
ATOM   3233 N N      . LYS A 1 214 ? 40.22400 -19.24600 4.16000   1.000 48.20000  ? 214 LYS A N      1 
ATOM   3234 C CA     . LYS A 1 214 ? 40.75400 -20.52200 4.69500   1.000 47.13000  ? 214 LYS A CA     1 
ATOM   3235 C C      . LYS A 1 214 ? 42.25400 -20.38700 4.97400   1.000 59.14000  ? 214 LYS A C      1 
ATOM   3236 O O      . LYS A 1 214 ? 42.98400 -19.93100 4.08000   1.000 58.87000  ? 214 LYS A O      1 
ATOM   3237 C CB     . LYS A 1 214 ? 40.48300 -21.62300 3.67400   1.000 47.89000  ? 214 LYS A CB     1 
ATOM   3238 H H      . LYS A 1 214 ? 40.62600 -18.95700 3.40500   1.000 58.22000  ? 214 LYS A H      1 
ATOM   3239 H HA     . LYS A 1 214 ? 40.29400 -20.74300 5.54000   1.000 56.94000  ? 214 LYS A HA     1 
ATOM   3240 N N      . GLU A 1 215 ? 42.69000 -20.77700 6.16900   1.000 59.33000  ? 215 GLU A N      1 
ATOM   3241 C CA     . GLU A 1 215 ? 44.11700 -20.71300 6.54900   1.000 46.91000  ? 215 GLU A CA     1 
ATOM   3242 C C      . GLU A 1 215 ? 44.87300 -21.82400 5.83100   1.000 44.83000  ? 215 GLU A C      1 
ATOM   3243 O O      . GLU A 1 215 ? 44.37600 -22.95600 5.83400   1.000 58.68000  ? 215 GLU A O      1 
ATOM   3244 C CB     . GLU A 1 215 ? 44.29500 -20.86600 8.05500   1.000 41.21000  ? 215 GLU A CB     1 
ATOM   3245 C CG     . GLU A 1 215 ? 45.74400 -21.05700 8.49000   1.000 62.07000  ? 215 GLU A CG     1 
ATOM   3246 C CD     . GLU A 1 215 ? 45.96500 -21.06600 9.99000   1.000 77.77000  ? 215 GLU A CD     1 
ATOM   3247 O OE1    . GLU A 1 215 ? 45.01900 -20.78100 10.75100  1.000 62.60000  ? 215 GLU A OE1    1 
ATOM   3248 O OE2    . GLU A 1 215 ? 47.10100 -21.37700 10.39500  1.000 68.67000  ? 215 GLU A OE2    1 
ATOM   3249 H H      . GLU A 1 215 ? 42.12600 -21.09600 6.79700   1.000 71.58000  ? 215 GLU A H      1 
ATOM   3250 H HA     . GLU A 1 215 ? 44.48300 -19.83900 6.26700   1.000 56.68000  ? 215 GLU A HA     1 
ATOM   3251 H HB2    . GLU A 1 215 ? 43.92700 -20.07100 8.49200   1.000 49.83000  ? 215 GLU A HB2    1 
ATOM   3252 H HB3    . GLU A 1 215 ? 43.77400 -21.64000 8.35400   1.000 49.83000  ? 215 GLU A HB3    1 
ATOM   3253 H HG2    . GLU A 1 215 ? 46.07600 -21.90500 8.13400   1.000 74.87000  ? 215 GLU A HG2    1 
ATOM   3254 H HG3    . GLU A 1 215 ? 46.28900 -20.34200 8.10000   1.000 74.87000  ? 215 GLU A HG3    1 
ATOM   3255 N N      . VAL A 1 216 ? 46.02000 -21.50100 5.24800   1.000 53.48000  ? 216 VAL A N      1 
ATOM   3256 C CA     . VAL A 1 216 ? 46.89700 -22.51300 4.60400   1.000 51.23000  ? 216 VAL A CA     1 
ATOM   3257 C C      . VAL A 1 216 ? 47.77300 -23.10100 5.71000   1.000 58.10000  ? 216 VAL A C      1 
ATOM   3258 O O      . VAL A 1 216 ? 48.31300 -22.31000 6.50200   1.000 57.96000  ? 216 VAL A O      1 
ATOM   3259 C CB     . VAL A 1 216 ? 47.74200 -21.90300 3.47800   1.000 60.91000  ? 216 VAL A CB     1 
ATOM   3260 C CG1    . VAL A 1 216 ? 48.70800 -22.92200 2.89300   1.000 69.38000  ? 216 VAL A CG1    1 
ATOM   3261 C CG2    . VAL A 1 216 ? 46.86500 -21.30000 2.39300   1.000 58.09000  ? 216 VAL A CG2    1 
ATOM   3262 H H      . VAL A 1 216 ? 46.31900 -20.65000 5.22800   1.000 64.55000  ? 216 VAL A H      1 
ATOM   3263 H HA     . VAL A 1 216 ? 46.34200 -23.22100 4.22900   1.000 61.86000  ? 216 VAL A HA     1 
ATOM   3264 H HB     . VAL A 1 216 ? 48.27200 -21.17600 3.87500   1.000 73.47000  ? 216 VAL A HB     1 
ATOM   3265 H HG11   . VAL A 1 216 ? 48.91300 -22.68400 1.97400   1.000 83.64000  ? 216 VAL A HG11   1 
ATOM   3266 H HG12   . VAL A 1 216 ? 49.52700 -22.93100 3.41600   1.000 83.64000  ? 216 VAL A HG12   1 
ATOM   3267 H HG13   . VAL A 1 216 ? 48.30000 -23.80400 2.91600   1.000 83.64000  ? 216 VAL A HG13   1 
ATOM   3268 H HG21   . VAL A 1 216 ? 47.39400 -21.15100 1.59200   1.000 70.09000  ? 216 VAL A HG21   1 
ATOM   3269 H HG22   . VAL A 1 216 ? 46.13600 -21.91000 2.19200   1.000 70.09000  ? 216 VAL A HG22   1 
ATOM   3270 H HG23   . VAL A 1 216 ? 46.50100 -20.45400 2.70300   1.000 70.09000  ? 216 VAL A HG23   1 
ATOM   3271 N N      . GLU A 1 217 ? 47.88500 -24.42400 5.76500   1.000 73.14000  ? 217 GLU A N      1 
ATOM   3272 C CA     . GLU A 1 217 ? 48.65200 -25.12000 6.82500   1.000 90.10000  ? 217 GLU A CA     1 
ATOM   3273 C C      . GLU A 1 217 ? 49.47600 -26.24300 6.18300   1.000 96.43000  ? 217 GLU A C      1 
ATOM   3274 O O      . GLU A 1 217 ? 49.08600 -26.66100 5.07700   1.000 88.18000  ? 217 GLU A O      1 
ATOM   3275 C CB     . GLU A 1 217 ? 47.66100 -25.65200 7.85700   1.000 93.86000  ? 217 GLU A CB     1 
ATOM   3276 C CG     . GLU A 1 217 ? 46.67400 -24.60200 8.35800   1.000 96.44000  ? 217 GLU A CG     1 
ATOM   3277 C CD     . GLU A 1 217 ? 45.81300 -25.05400 9.52100   1.000 99.97000  ? 217 GLU A CD     1 
ATOM   3278 O OE1    . GLU A 1 217 ? 45.61600 -26.27500 9.67700   1.000 131.73000 ? 217 GLU A OE1    1 
ATOM   3279 O OE2    . GLU A 1 217 ? 45.33200 -24.17900 10.26700  1.000 114.05000 ? 217 GLU A OE2    1 
ATOM   3280 H H      . GLU A 1 217 ? 47.49300 -24.95400 5.15100   1.000 88.15000  ? 217 GLU A H      1 
ATOM   3281 H HA     . GLU A 1 217 ? 49.26700 -24.47900 7.25800   1.000 108.50000 ? 217 GLU A HA     1 
ATOM   3282 H HB2    . GLU A 1 217 ? 47.16200 -26.39200 7.45500   1.000 113.02000 ? 217 GLU A HB2    1 
ATOM   3283 H HB3    . GLU A 1 217 ? 48.16200 -26.00700 8.61900   1.000 113.02000 ? 217 GLU A HB3    1 
ATOM   3284 H HG2    . GLU A 1 217 ? 47.17100 -23.80300 8.63200   1.000 116.11000 ? 217 GLU A HG2    1 
ATOM   3285 H HG3    . GLU A 1 217 ? 46.08000 -24.34200 7.62300   1.000 116.11000 ? 217 GLU A HG3    1 
HETATM 3286 P PG     . ANP B 2 .   ? 12.66000 -5.52000  -6.66300  1.000 160.07000 ? 301 ANP A PG     1 
HETATM 3287 O O1G    . ANP B 2 .   ? 12.61700 -4.19500  -7.42000  1.000 131.87000 ? 301 ANP A O1G    1 
HETATM 3288 O O2G    . ANP B 2 .   ? 11.61900 -6.53600  -7.15000  1.000 129.97000 ? 301 ANP A O2G    1 
HETATM 3289 O O3G    . ANP B 2 .   ? 14.06600 -6.10100  -6.46900  1.000 103.81000 ? 301 ANP A O3G    1 
HETATM 3290 P PB     . ANP B 2 .   ? 10.90400 -4.98800  -4.03800  1.000 114.56000 ? 301 ANP A PB     1 
HETATM 3291 O O1B    . ANP B 2 .   ? 9.95300  -4.07100  -4.76200  1.000 119.81000 ? 301 ANP A O1B    1 
HETATM 3292 O O2B    . ANP B 2 .   ? 10.42300 -6.25700  -3.40000  1.000 107.27000 ? 301 ANP A O2B    1 
HETATM 3293 N N3B    . ANP B 2 .   ? 12.33700 -5.22300  -4.90100  1.000 128.51000 ? 301 ANP A N3B    1 
HETATM 3294 P PA     . ANP B 2 .   ? 12.19500 -4.14800  -1.33900  1.000 110.28000 ? 301 ANP A PA     1 
HETATM 3295 O O1A    . ANP B 2 .   ? 11.60300 -3.29600  -0.28000  1.000 78.10000  ? 301 ANP A O1A    1 
HETATM 3296 O O2A    . ANP B 2 .   ? 12.52200 -5.59700  -0.98600  1.000 72.40000  ? 301 ANP A O2A    1 
HETATM 3297 O O3A    . ANP B 2 .   ? 11.41900 -3.94100  -2.76600  1.000 130.39000 ? 301 ANP A O3A    1 
HETATM 3298 O "O5'"  . ANP B 2 .   ? 13.55000 -3.28000  -1.74700  1.000 85.56000  ? 301 ANP A "O5'"  1 
HETATM 3299 C "C5'"  . ANP B 2 .   ? 13.53300 -1.85300  -1.72300  1.000 94.83000  ? 301 ANP A "C5'"  1 
HETATM 3300 C "C4'"  . ANP B 2 .   ? 13.87700 -1.16900  -3.04000  1.000 93.63000  ? 301 ANP A "C4'"  1 
HETATM 3301 O "O4'"  . ANP B 2 .   ? 15.28000 -0.85000  -2.98200  1.000 98.29000  ? 301 ANP A "O4'"  1 
HETATM 3302 C "C3'"  . ANP B 2 .   ? 13.64200 -1.95000  -4.31500  1.000 103.55000 ? 301 ANP A "C3'"  1 
HETATM 3303 O "O3'"  . ANP B 2 .   ? 12.39300 -1.73600  -4.91300  1.000 107.71000 ? 301 ANP A "O3'"  1 
HETATM 3304 C "C2'"  . ANP B 2 .   ? 14.81800 -1.51900  -5.19700  1.000 108.56000 ? 301 ANP A "C2'"  1 
HETATM 3305 O "O2'"  . ANP B 2 .   ? 14.38500 -0.39600  -5.94900  1.000 88.50000  ? 301 ANP A "O2'"  1 
HETATM 3306 C "C1'"  . ANP B 2 .   ? 15.93000 -1.21700  -4.16000  1.000 103.36000 ? 301 ANP A "C1'"  1 
HETATM 3307 N N9     . ANP B 2 .   ? 16.80900 -2.36600  -3.85200  1.000 78.46000  ? 301 ANP A N9     1 
HETATM 3308 C C8     . ANP B 2 .   ? 16.71300 -3.25100  -2.80500  1.000 66.37000  ? 301 ANP A C8     1 
HETATM 3309 N N7     . ANP B 2 .   ? 17.63200 -4.16600  -2.81000  1.000 63.18000  ? 301 ANP A N7     1 
HETATM 3310 C C5     . ANP B 2 .   ? 18.41400 -3.88000  -3.91000  1.000 77.10000  ? 301 ANP A C5     1 
HETATM 3311 C C6     . ANP B 2 .   ? 19.59200 -4.47300  -4.47200  1.000 55.64000  ? 301 ANP A C6     1 
HETATM 3312 N N6     . ANP B 2 .   ? 20.19700 -5.57400  -3.98400  1.000 46.45000  ? 301 ANP A N6     1 
HETATM 3313 N N1     . ANP B 2 .   ? 20.10800 -3.90800  -5.57700  1.000 63.01000  ? 301 ANP A N1     1 
HETATM 3314 C C2     . ANP B 2 .   ? 19.52400 -2.81300  -6.12800  1.000 65.22000  ? 301 ANP A C2     1 
HETATM 3315 N N3     . ANP B 2 .   ? 18.42900 -2.18200  -5.68900  1.000 86.54000  ? 301 ANP A N3     1 
HETATM 3316 C C4     . ANP B 2 .   ? 17.90800 -2.75100  -4.57300  1.000 85.93000  ? 301 ANP A C4     1 
HETATM 3317 H HNB1   . ANP B 2 .   ? 12.91400 -5.68700  -4.40800  1.000 154.59000 ? 301 ANP A HNB1   1 
HETATM 3318 H "H5'1" . ANP B 2 .   ? 14.16100 -1.50900  -1.06900  1.000 114.18000 ? 301 ANP A "H5'1" 1 
HETATM 3319 H "H5'2" . ANP B 2 .   ? 12.65700 -1.52100  -1.46800  1.000 114.18000 ? 301 ANP A "H5'2" 1 
HETATM 3320 H "H4'"  . ANP B 2 .   ? 13.34900 -0.36100  -3.14500  1.000 112.74000 ? 301 ANP A "H4'"  1 
HETATM 3321 H "H3'"  . ANP B 2 .   ? 13.79600 -2.88200  -4.09700  1.000 124.64000 ? 301 ANP A "H3'"  1 
HETATM 3322 H "HO3'" . ANP B 2 .   ? 12.44100 -0.93300  -5.18600  1.000 129.63000 ? 301 ANP A "HO3'" 1 
HETATM 3323 H "H2'"  . ANP B 2 .   ? 15.16200 -2.23000  -5.76000  1.000 130.66000 ? 301 ANP A "H2'"  1 
HETATM 3324 H "HO2'" . ANP B 2 .   ? 14.01100 0.15900   -5.42500  1.000 106.58000 ? 301 ANP A "HO2'" 1 
HETATM 3325 H "H1'"  . ANP B 2 .   ? 16.51800 -0.52300  -4.49600  1.000 124.41000 ? 301 ANP A "H1'"  1 
HETATM 3326 H H8     . ANP B 2 .   ? 16.04100 -3.17800  -2.16500  1.000 80.02000  ? 301 ANP A H8     1 
HETATM 3327 H HN61   . ANP B 2 .   ? 21.07300 -5.59500  -3.88500  1.000 56.12000  ? 301 ANP A HN61   1 
HETATM 3328 H HN62   . ANP B 2 .   ? 19.72400 -6.29600  -3.76000  1.000 56.12000  ? 301 ANP A HN62   1 
HETATM 3329 H H2     . ANP B 2 .   ? 19.93100 -2.46900  -6.89000  1.000 78.65000  ? 301 ANP A H2     1 
HETATM 3330 O O      . HOH C 3 .   ? 1.41900  -13.36600 11.66600  1.000 50.28000  ? 401 HOH A O      1 
HETATM 3331 O O      . HOH C 3 .   ? 27.37700 5.66200   6.96500   1.000 51.05000  ? 402 HOH A O      1 
HETATM 3332 O O      . HOH C 3 .   ? 14.98800 -11.79600 -10.66700 1.000 38.89000  ? 403 HOH A O      1 
HETATM 3333 O O      . HOH C 3 .   ? 16.14400 -4.77300  -6.28200  1.000 46.23000  ? 404 HOH A O      1 
HETATM 3334 O O      . HOH C 3 .   ? 18.40700 -5.69400  -1.00300  1.000 33.98000  ? 405 HOH A O      1 
HETATM 3335 O O      . HOH C 3 .   ? 25.21800 5.54800   -7.50200  1.000 38.06000  ? 406 HOH A O      1 
HETATM 3336 O O      . HOH C 3 .   ? 20.92300 2.89000   -19.57300 1.000 49.29000  ? 407 HOH A O      1 
HETATM 3337 O O      . HOH C 3 .   ? 22.31600 -3.23400  -7.53700  1.000 36.19000  ? 408 HOH A O      1 
HETATM 3338 O O      . HOH C 3 .   ? 32.40700 1.66000   -7.75100  1.000 43.74000  ? 409 HOH A O      1 
HETATM 3339 O O      . HOH C 3 .   ? 20.28300 -7.41600  -1.97400  1.000 32.76000  ? 410 HOH A O      1 
HETATM 3340 O O      . HOH C 3 .   ? 28.63800 2.10800   -12.40600 1.000 40.92000  ? 411 HOH A O      1 
HETATM 3341 O O      . HOH C 3 .   ? 32.43800 7.64700   -3.88100  1.000 44.46000  ? 412 HOH A O      1 
HETATM 3342 O O      . HOH C 3 .   ? 16.06700 -11.09700 18.04200  1.000 58.07000  ? 413 HOH A O      1 
HETATM 3343 O O      . HOH C 3 .   ? 33.18700 -20.91800 8.11600   1.000 53.17000  ? 414 HOH A O      1 
HETATM 3344 O O      . HOH C 3 .   ? 22.81800 -7.36600  -2.65800  1.000 26.06000  ? 415 HOH A O      1 
HETATM 3345 O O      . HOH C 3 .   ? 31.46500 -23.52200 8.30600   1.000 48.37000  ? 416 HOH A O      1 
# 
