data_9MSU
# 
_entry.id   9MSU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MSU         pdb_00009msu 10.2210/pdb9msu/pdb 
WWPDB D_1000291667 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-04 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MSU 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          9MSQ 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              redinbo@unc.edu 
_pdbx_contact_author.name_first         Matthew 
_pdbx_contact_author.name_last          Redinbo 
_pdbx_contact_author.name_mi            R 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0814-5346 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kowalewski, M.E.' 1 0000-0001-9455-7333 
'Redinbo, M.R.'    2 0000-0003-0814-5346 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochemistry 
_citation.journal_id_ASTM           BICHAW 
_citation.journal_id_CSD            0033 
_citation.journal_id_ISSN           0006-2960 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            64 
_citation.language                  ? 
_citation.page_first                2401 
_citation.page_last                 2411 
_citation.title                     'Structural Insights into Selectively Targeting Candida albicans Hsp90.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.biochem.5c00015 
_citation.pdbx_database_id_PubMed   40397669 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kowalewski, M.E.' 1 ? 
primary 'Zagler, S.'       2 ? 
primary 'Redinbo, M.R.'    3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Heat shock protein 90 homolog'                                                                         
26350.838 1   ? ? ? ? 
2 non-polymer syn 'ethyl (4-{3-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-5-sulfanyl-4H-1,2,4-triazol-4-yl}benzyl)carbamate' 428.505 
1   ? ? ? ? 
3 non-polymer syn 1,2-ETHANEDIOL                                                                                          62.068 1 
? ? ? ? 
4 water       nat water                                                                                                   18.015 
291 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ethyl (4-{3-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-5-sulfanyl-4H-1,2,4-triazol-4-yl}benzyl)carbamate' 819 
3 1,2-ETHANEDIOL                                                                                          EDO 
4 water                                                                                                   HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   ASP n 
1 4   ALA n 
1 5   LYS n 
1 6   VAL n 
1 7   GLU n 
1 8   THR n 
1 9   HIS n 
1 10  GLU n 
1 11  PHE n 
1 12  THR n 
1 13  ALA n 
1 14  GLU n 
1 15  ILE n 
1 16  SER n 
1 17  GLN n 
1 18  LEU n 
1 19  MET n 
1 20  SER n 
1 21  LEU n 
1 22  ILE n 
1 23  ILE n 
1 24  ASN n 
1 25  THR n 
1 26  VAL n 
1 27  TYR n 
1 28  SER n 
1 29  ASN n 
1 30  LYS n 
1 31  GLU n 
1 32  ILE n 
1 33  PHE n 
1 34  LEU n 
1 35  ARG n 
1 36  GLU n 
1 37  LEU n 
1 38  ILE n 
1 39  SER n 
1 40  ASN n 
1 41  ALA n 
1 42  SER n 
1 43  ASP n 
1 44  ALA n 
1 45  LEU n 
1 46  ASP n 
1 47  LYS n 
1 48  ILE n 
1 49  ARG n 
1 50  TYR n 
1 51  GLN n 
1 52  ALA n 
1 53  LEU n 
1 54  SER n 
1 55  ASP n 
1 56  PRO n 
1 57  SER n 
1 58  GLN n 
1 59  LEU n 
1 60  GLU n 
1 61  SER n 
1 62  GLU n 
1 63  PRO n 
1 64  GLU n 
1 65  LEU n 
1 66  PHE n 
1 67  ILE n 
1 68  ARG n 
1 69  ILE n 
1 70  ILE n 
1 71  PRO n 
1 72  GLN n 
1 73  LYS n 
1 74  ASP n 
1 75  GLN n 
1 76  LYS n 
1 77  VAL n 
1 78  LEU n 
1 79  GLU n 
1 80  ILE n 
1 81  ARG n 
1 82  ASP n 
1 83  SER n 
1 84  GLY n 
1 85  ILE n 
1 86  GLY n 
1 87  MET n 
1 88  THR n 
1 89  LYS n 
1 90  ALA n 
1 91  ASP n 
1 92  LEU n 
1 93  VAL n 
1 94  ASN n 
1 95  ASN n 
1 96  LEU n 
1 97  GLY n 
1 98  THR n 
1 99  ILE n 
1 100 ALA n 
1 101 LYS n 
1 102 SER n 
1 103 GLY n 
1 104 THR n 
1 105 LYS n 
1 106 SER n 
1 107 PHE n 
1 108 MET n 
1 109 GLU n 
1 110 ALA n 
1 111 LEU n 
1 112 SER n 
1 113 ALA n 
1 114 GLY n 
1 115 ALA n 
1 116 ASP n 
1 117 VAL n 
1 118 SER n 
1 119 MET n 
1 120 ILE n 
1 121 GLY n 
1 122 GLN n 
1 123 PHE n 
1 124 GLY n 
1 125 VAL n 
1 126 GLY n 
1 127 PHE n 
1 128 TYR n 
1 129 SER n 
1 130 LEU n 
1 131 PHE n 
1 132 LEU n 
1 133 VAL n 
1 134 ALA n 
1 135 ASP n 
1 136 HIS n 
1 137 VAL n 
1 138 GLN n 
1 139 VAL n 
1 140 ILE n 
1 141 SER n 
1 142 LYS n 
1 143 HIS n 
1 144 ASN n 
1 145 ASP n 
1 146 ASP n 
1 147 GLU n 
1 148 GLN n 
1 149 TYR n 
1 150 VAL n 
1 151 TRP n 
1 152 GLU n 
1 153 SER n 
1 154 ASN n 
1 155 ALA n 
1 156 GLY n 
1 157 GLY n 
1 158 LYS n 
1 159 PHE n 
1 160 THR n 
1 161 VAL n 
1 162 THR n 
1 163 LEU n 
1 164 ASP n 
1 165 GLU n 
1 166 THR n 
1 167 ASN n 
1 168 GLU n 
1 169 ARG n 
1 170 LEU n 
1 171 GLY n 
1 172 ARG n 
1 173 GLY n 
1 174 THR n 
1 175 MET n 
1 176 LEU n 
1 177 ARG n 
1 178 LEU n 
1 179 PHE n 
1 180 LEU n 
1 181 LYS n 
1 182 GLU n 
1 183 ASP n 
1 184 GLN n 
1 185 LEU n 
1 186 GLU n 
1 187 TYR n 
1 188 LEU n 
1 189 GLU n 
1 190 GLU n 
1 191 LYS n 
1 192 ARG n 
1 193 ILE n 
1 194 LYS n 
1 195 GLU n 
1 196 VAL n 
1 197 VAL n 
1 198 LYS n 
1 199 LYS n 
1 200 HIS n 
1 201 SER n 
1 202 GLU n 
1 203 PHE n 
1 204 VAL n 
1 205 ALA n 
1 206 TYR n 
1 207 PRO n 
1 208 ILE n 
1 209 GLN n 
1 210 LEU n 
1 211 VAL n 
1 212 VAL n 
1 213 THR n 
1 214 LYS n 
1 215 GLU n 
1 216 VAL n 
1 217 GLU n 
1 218 LYS n 
1 219 ASN n 
1 220 LEU n 
1 221 TYR n 
1 222 PHE n 
1 223 GLN n 
1 224 SER n 
1 225 GLY n 
1 226 SER n 
1 227 HIS n 
1 228 HIS n 
1 229 HIS n 
1 230 HIS n 
1 231 HIS n 
1 232 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   232 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'HSP90, CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Candida albicans' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5476 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
819 non-polymer         . 'ethyl (4-{3-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-5-sulfanyl-4H-1,2,4-triazol-4-yl}benzyl)carbamate' 
?                 'C21 H24 N4 O4 S' 428.505 
ALA 'L-peptide linking' y ALANINE                                                                                                 
?                 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                                                                                                
?                 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                              
?                 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                         
?                 'C4 H7 N O4'      133.103 
EDO non-polymer         . 1,2-ETHANEDIOL                                                                                          
'ETHYLENE GLYCOL' 'C2 H6 O2'        62.068  
GLN 'L-peptide linking' y GLUTAMINE                                                                                               
?                 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                         
?                 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                 
?                 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                               
?                 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                                                                                   
?                 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                              
?                 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                 
?                 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                  
?                 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                                                                                              
?                 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                           
?                 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                 
?                 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                                                                                  
?                 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                                                                                               
?                 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                              
?                 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                                
?                 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                                                                                  
?                 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   ASP 3   3   3   ASP ASP A . n 
A 1 4   ALA 4   4   4   ALA ALA A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   THR 8   8   8   THR THR A . n 
A 1 9   HIS 9   9   9   HIS HIS A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  ALA 13  13  13  ALA ALA A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  SER 16  16  16  SER SER A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  MET 19  19  19  MET MET A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  ILE 22  22  22  ILE ILE A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  ASN 24  24  24  ASN ASN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  VAL 26  26  26  VAL VAL A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  PHE 33  33  33  PHE PHE A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  GLU 36  36  36  GLU GLU A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  ASP 43  43  43  ASP ASP A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  ASP 46  46  46  ASP ASP A . n 
A 1 47  LYS 47  47  47  LYS LYS A . n 
A 1 48  ILE 48  48  48  ILE ILE A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  TYR 50  50  50  TYR TYR A . n 
A 1 51  GLN 51  51  51  GLN GLN A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  PRO 56  56  56  PRO PRO A . n 
A 1 57  SER 57  57  57  SER SER A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  GLU 60  60  60  GLU GLU A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  ILE 67  67  67  ILE ILE A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  ILE 69  69  69  ILE ILE A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  GLU 79  79  79  GLU GLU A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ARG 81  81  81  ARG ARG A . n 
A 1 82  ASP 82  82  82  ASP ASP A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  MET 87  87  87  MET MET A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  GLY 97  97  97  GLY GLY A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 ALA 100 100 100 ALA ALA A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 LYS 105 105 105 LYS LYS A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 MET 108 108 108 MET MET A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 MET 119 119 119 MET MET A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLN 122 122 122 GLN GLN A . n 
A 1 123 PHE 123 123 123 PHE PHE A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 PHE 127 127 127 PHE PHE A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 PHE 131 131 131 PHE PHE A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 HIS 136 136 136 HIS HIS A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 SER 141 141 141 SER SER A . n 
A 1 142 LYS 142 142 142 LYS LYS A . n 
A 1 143 HIS 143 143 143 HIS HIS A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 GLU 147 147 147 GLU GLU A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 TRP 151 151 151 TRP TRP A . n 
A 1 152 GLU 152 152 152 GLU GLU A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 GLY 156 156 156 GLY GLY A . n 
A 1 157 GLY 157 157 157 GLY GLY A . n 
A 1 158 LYS 158 158 158 LYS LYS A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLU 165 165 165 GLU GLU A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 ASN 167 167 167 ASN ASN A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLY 171 171 171 GLY GLY A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 MET 175 175 175 MET MET A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 PHE 179 179 179 PHE PHE A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 LYS 181 181 181 LYS LYS A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 GLN 184 184 184 GLN GLN A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 GLU 186 186 186 GLU GLU A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 LYS 194 194 194 LYS LYS A . n 
A 1 195 GLU 195 195 195 GLU GLU A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 LYS 198 198 198 LYS LYS A . n 
A 1 199 LYS 199 199 199 LYS LYS A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 GLU 202 202 202 GLU GLU A . n 
A 1 203 PHE 203 203 203 PHE PHE A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 PRO 207 207 207 PRO PRO A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 GLN 209 209 209 GLN GLN A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 GLU 215 215 215 GLU GLU A . n 
A 1 216 VAL 216 216 216 VAL VAL A . n 
A 1 217 GLU 217 217 217 GLU GLU A . n 
A 1 218 LYS 218 218 218 LYS LYS A . n 
A 1 219 ASN 219 219 ?   ?   ?   A . n 
A 1 220 LEU 220 220 ?   ?   ?   A . n 
A 1 221 TYR 221 221 ?   ?   ?   A . n 
A 1 222 PHE 222 222 ?   ?   ?   A . n 
A 1 223 GLN 223 223 ?   ?   ?   A . n 
A 1 224 SER 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 SER 226 226 ?   ?   ?   A . n 
A 1 227 HIS 227 227 ?   ?   ?   A . n 
A 1 228 HIS 228 228 ?   ?   ?   A . n 
A 1 229 HIS 229 229 ?   ?   ?   A . n 
A 1 230 HIS 230 230 ?   ?   ?   A . n 
A 1 231 HIS 231 231 ?   ?   ?   A . n 
A 1 232 HIS 232 232 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        819 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   819 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 819 1   301 301 819 819 A . 
C 3 EDO 1   302 298 EDO EDO A . 
D 4 HOH 1   401 280 HOH HOH A . 
D 4 HOH 2   402 104 HOH HOH A . 
D 4 HOH 3   403 163 HOH HOH A . 
D 4 HOH 4   404 91  HOH HOH A . 
D 4 HOH 5   405 160 HOH HOH A . 
D 4 HOH 6   406 237 HOH HOH A . 
D 4 HOH 7   407 268 HOH HOH A . 
D 4 HOH 8   408 146 HOH HOH A . 
D 4 HOH 9   409 199 HOH HOH A . 
D 4 HOH 10  410 256 HOH HOH A . 
D 4 HOH 11  411 176 HOH HOH A . 
D 4 HOH 12  412 142 HOH HOH A . 
D 4 HOH 13  413 124 HOH HOH A . 
D 4 HOH 14  414 29  HOH HOH A . 
D 4 HOH 15  415 59  HOH HOH A . 
D 4 HOH 16  416 169 HOH HOH A . 
D 4 HOH 17  417 281 HOH HOH A . 
D 4 HOH 18  418 123 HOH HOH A . 
D 4 HOH 19  419 261 HOH HOH A . 
D 4 HOH 20  420 13  HOH HOH A . 
D 4 HOH 21  421 264 HOH HOH A . 
D 4 HOH 22  422 35  HOH HOH A . 
D 4 HOH 23  423 108 HOH HOH A . 
D 4 HOH 24  424 191 HOH HOH A . 
D 4 HOH 25  425 210 HOH HOH A . 
D 4 HOH 26  426 17  HOH HOH A . 
D 4 HOH 27  427 106 HOH HOH A . 
D 4 HOH 28  428 246 HOH HOH A . 
D 4 HOH 29  429 21  HOH HOH A . 
D 4 HOH 30  430 253 HOH HOH A . 
D 4 HOH 31  431 288 HOH HOH A . 
D 4 HOH 32  432 1   HOH HOH A . 
D 4 HOH 33  433 131 HOH HOH A . 
D 4 HOH 34  434 87  HOH HOH A . 
D 4 HOH 35  435 164 HOH HOH A . 
D 4 HOH 36  436 133 HOH HOH A . 
D 4 HOH 37  437 5   HOH HOH A . 
D 4 HOH 38  438 10  HOH HOH A . 
D 4 HOH 39  439 153 HOH HOH A . 
D 4 HOH 40  440 202 HOH HOH A . 
D 4 HOH 41  441 65  HOH HOH A . 
D 4 HOH 42  442 125 HOH HOH A . 
D 4 HOH 43  443 92  HOH HOH A . 
D 4 HOH 44  444 58  HOH HOH A . 
D 4 HOH 45  445 167 HOH HOH A . 
D 4 HOH 46  446 44  HOH HOH A . 
D 4 HOH 47  447 85  HOH HOH A . 
D 4 HOH 48  448 54  HOH HOH A . 
D 4 HOH 49  449 252 HOH HOH A . 
D 4 HOH 50  450 100 HOH HOH A . 
D 4 HOH 51  451 193 HOH HOH A . 
D 4 HOH 52  452 117 HOH HOH A . 
D 4 HOH 53  453 9   HOH HOH A . 
D 4 HOH 54  454 32  HOH HOH A . 
D 4 HOH 55  455 25  HOH HOH A . 
D 4 HOH 56  456 52  HOH HOH A . 
D 4 HOH 57  457 130 HOH HOH A . 
D 4 HOH 58  458 3   HOH HOH A . 
D 4 HOH 59  459 244 HOH HOH A . 
D 4 HOH 60  460 88  HOH HOH A . 
D 4 HOH 61  461 73  HOH HOH A . 
D 4 HOH 62  462 66  HOH HOH A . 
D 4 HOH 63  463 18  HOH HOH A . 
D 4 HOH 64  464 139 HOH HOH A . 
D 4 HOH 65  465 43  HOH HOH A . 
D 4 HOH 66  466 226 HOH HOH A . 
D 4 HOH 67  467 96  HOH HOH A . 
D 4 HOH 68  468 116 HOH HOH A . 
D 4 HOH 69  469 247 HOH HOH A . 
D 4 HOH 70  470 2   HOH HOH A . 
D 4 HOH 71  471 8   HOH HOH A . 
D 4 HOH 72  472 239 HOH HOH A . 
D 4 HOH 73  473 135 HOH HOH A . 
D 4 HOH 74  474 18  HOH HOH A . 
D 4 HOH 75  475 62  HOH HOH A . 
D 4 HOH 76  476 55  HOH HOH A . 
D 4 HOH 77  477 166 HOH HOH A . 
D 4 HOH 78  478 149 HOH HOH A . 
D 4 HOH 79  479 154 HOH HOH A . 
D 4 HOH 80  480 16  HOH HOH A . 
D 4 HOH 81  481 113 HOH HOH A . 
D 4 HOH 82  482 45  HOH HOH A . 
D 4 HOH 83  483 99  HOH HOH A . 
D 4 HOH 84  484 27  HOH HOH A . 
D 4 HOH 85  485 68  HOH HOH A . 
D 4 HOH 86  486 187 HOH HOH A . 
D 4 HOH 87  487 11  HOH HOH A . 
D 4 HOH 88  488 112 HOH HOH A . 
D 4 HOH 89  489 23  HOH HOH A . 
D 4 HOH 90  490 50  HOH HOH A . 
D 4 HOH 91  491 254 HOH HOH A . 
D 4 HOH 92  492 4   HOH HOH A . 
D 4 HOH 93  493 7   HOH HOH A . 
D 4 HOH 94  494 171 HOH HOH A . 
D 4 HOH 95  495 217 HOH HOH A . 
D 4 HOH 96  496 84  HOH HOH A . 
D 4 HOH 97  497 53  HOH HOH A . 
D 4 HOH 98  498 72  HOH HOH A . 
D 4 HOH 99  499 34  HOH HOH A . 
D 4 HOH 100 500 49  HOH HOH A . 
D 4 HOH 101 501 290 HOH HOH A . 
D 4 HOH 102 502 31  HOH HOH A . 
D 4 HOH 103 503 78  HOH HOH A . 
D 4 HOH 104 504 206 HOH HOH A . 
D 4 HOH 105 505 61  HOH HOH A . 
D 4 HOH 106 506 127 HOH HOH A . 
D 4 HOH 107 507 60  HOH HOH A . 
D 4 HOH 108 508 105 HOH HOH A . 
D 4 HOH 109 509 26  HOH HOH A . 
D 4 HOH 110 510 95  HOH HOH A . 
D 4 HOH 111 511 64  HOH HOH A . 
D 4 HOH 112 512 47  HOH HOH A . 
D 4 HOH 113 513 278 HOH HOH A . 
D 4 HOH 114 514 28  HOH HOH A . 
D 4 HOH 115 515 111 HOH HOH A . 
D 4 HOH 116 516 76  HOH HOH A . 
D 4 HOH 117 517 122 HOH HOH A . 
D 4 HOH 118 518 81  HOH HOH A . 
D 4 HOH 119 519 17  HOH HOH A . 
D 4 HOH 120 520 282 HOH HOH A . 
D 4 HOH 121 521 6   HOH HOH A . 
D 4 HOH 122 522 6   HOH HOH A . 
D 4 HOH 123 523 155 HOH HOH A . 
D 4 HOH 124 524 157 HOH HOH A . 
D 4 HOH 125 525 162 HOH HOH A . 
D 4 HOH 126 526 152 HOH HOH A . 
D 4 HOH 127 527 98  HOH HOH A . 
D 4 HOH 128 528 14  HOH HOH A . 
D 4 HOH 129 529 115 HOH HOH A . 
D 4 HOH 130 530 71  HOH HOH A . 
D 4 HOH 131 531 144 HOH HOH A . 
D 4 HOH 132 532 234 HOH HOH A . 
D 4 HOH 133 533 178 HOH HOH A . 
D 4 HOH 134 534 40  HOH HOH A . 
D 4 HOH 135 535 151 HOH HOH A . 
D 4 HOH 136 536 119 HOH HOH A . 
D 4 HOH 137 537 37  HOH HOH A . 
D 4 HOH 138 538 102 HOH HOH A . 
D 4 HOH 139 539 179 HOH HOH A . 
D 4 HOH 140 540 12  HOH HOH A . 
D 4 HOH 141 541 70  HOH HOH A . 
D 4 HOH 142 542 126 HOH HOH A . 
D 4 HOH 143 543 275 HOH HOH A . 
D 4 HOH 144 544 80  HOH HOH A . 
D 4 HOH 145 545 90  HOH HOH A . 
D 4 HOH 146 546 159 HOH HOH A . 
D 4 HOH 147 547 86  HOH HOH A . 
D 4 HOH 148 548 38  HOH HOH A . 
D 4 HOH 149 549 197 HOH HOH A . 
D 4 HOH 150 550 214 HOH HOH A . 
D 4 HOH 151 551 287 HOH HOH A . 
D 4 HOH 152 552 195 HOH HOH A . 
D 4 HOH 153 553 227 HOH HOH A . 
D 4 HOH 154 554 75  HOH HOH A . 
D 4 HOH 155 555 82  HOH HOH A . 
D 4 HOH 156 556 83  HOH HOH A . 
D 4 HOH 157 557 265 HOH HOH A . 
D 4 HOH 158 558 33  HOH HOH A . 
D 4 HOH 159 559 205 HOH HOH A . 
D 4 HOH 160 560 175 HOH HOH A . 
D 4 HOH 161 561 57  HOH HOH A . 
D 4 HOH 162 562 20  HOH HOH A . 
D 4 HOH 163 563 110 HOH HOH A . 
D 4 HOH 164 564 46  HOH HOH A . 
D 4 HOH 165 565 30  HOH HOH A . 
D 4 HOH 166 566 67  HOH HOH A . 
D 4 HOH 167 567 207 HOH HOH A . 
D 4 HOH 168 568 22  HOH HOH A . 
D 4 HOH 169 569 148 HOH HOH A . 
D 4 HOH 170 570 240 HOH HOH A . 
D 4 HOH 171 571 200 HOH HOH A . 
D 4 HOH 172 572 89  HOH HOH A . 
D 4 HOH 173 573 132 HOH HOH A . 
D 4 HOH 174 574 168 HOH HOH A . 
D 4 HOH 175 575 109 HOH HOH A . 
D 4 HOH 176 576 48  HOH HOH A . 
D 4 HOH 177 577 235 HOH HOH A . 
D 4 HOH 178 578 24  HOH HOH A . 
D 4 HOH 179 579 36  HOH HOH A . 
D 4 HOH 180 580 218 HOH HOH A . 
D 4 HOH 181 581 15  HOH HOH A . 
D 4 HOH 182 582 19  HOH HOH A . 
D 4 HOH 183 583 42  HOH HOH A . 
D 4 HOH 184 584 262 HOH HOH A . 
D 4 HOH 185 585 225 HOH HOH A . 
D 4 HOH 186 586 270 HOH HOH A . 
D 4 HOH 187 587 118 HOH HOH A . 
D 4 HOH 188 588 241 HOH HOH A . 
D 4 HOH 189 589 93  HOH HOH A . 
D 4 HOH 190 590 114 HOH HOH A . 
D 4 HOH 191 591 39  HOH HOH A . 
D 4 HOH 192 592 273 HOH HOH A . 
D 4 HOH 193 593 51  HOH HOH A . 
D 4 HOH 194 594 15  HOH HOH A . 
D 4 HOH 195 595 143 HOH HOH A . 
D 4 HOH 196 596 196 HOH HOH A . 
D 4 HOH 197 597 292 HOH HOH A . 
D 4 HOH 198 598 165 HOH HOH A . 
D 4 HOH 199 599 183 HOH HOH A . 
D 4 HOH 200 600 204 HOH HOH A . 
D 4 HOH 201 601 3   HOH HOH A . 
D 4 HOH 202 602 41  HOH HOH A . 
D 4 HOH 203 603 186 HOH HOH A . 
D 4 HOH 204 604 156 HOH HOH A . 
D 4 HOH 205 605 198 HOH HOH A . 
D 4 HOH 206 606 266 HOH HOH A . 
D 4 HOH 207 607 19  HOH HOH A . 
D 4 HOH 208 608 14  HOH HOH A . 
D 4 HOH 209 609 97  HOH HOH A . 
D 4 HOH 210 610 231 HOH HOH A . 
D 4 HOH 211 611 140 HOH HOH A . 
D 4 HOH 212 612 269 HOH HOH A . 
D 4 HOH 213 613 136 HOH HOH A . 
D 4 HOH 214 614 172 HOH HOH A . 
D 4 HOH 215 615 107 HOH HOH A . 
D 4 HOH 216 616 267 HOH HOH A . 
D 4 HOH 217 617 177 HOH HOH A . 
D 4 HOH 218 618 212 HOH HOH A . 
D 4 HOH 219 619 189 HOH HOH A . 
D 4 HOH 220 620 13  HOH HOH A . 
D 4 HOH 221 621 190 HOH HOH A . 
D 4 HOH 222 622 137 HOH HOH A . 
D 4 HOH 223 623 173 HOH HOH A . 
D 4 HOH 224 624 258 HOH HOH A . 
D 4 HOH 225 625 16  HOH HOH A . 
D 4 HOH 226 626 272 HOH HOH A . 
D 4 HOH 227 627 129 HOH HOH A . 
D 4 HOH 228 628 224 HOH HOH A . 
D 4 HOH 229 629 291 HOH HOH A . 
D 4 HOH 230 630 180 HOH HOH A . 
D 4 HOH 231 631 145 HOH HOH A . 
D 4 HOH 232 632 215 HOH HOH A . 
D 4 HOH 233 633 74  HOH HOH A . 
D 4 HOH 234 634 213 HOH HOH A . 
D 4 HOH 235 635 174 HOH HOH A . 
D 4 HOH 236 636 69  HOH HOH A . 
D 4 HOH 237 637 243 HOH HOH A . 
D 4 HOH 238 638 238 HOH HOH A . 
D 4 HOH 239 639 120 HOH HOH A . 
D 4 HOH 240 640 201 HOH HOH A . 
D 4 HOH 241 641 94  HOH HOH A . 
D 4 HOH 242 642 101 HOH HOH A . 
D 4 HOH 243 643 2   HOH HOH A . 
D 4 HOH 244 644 211 HOH HOH A . 
D 4 HOH 245 645 228 HOH HOH A . 
D 4 HOH 246 646 63  HOH HOH A . 
D 4 HOH 247 647 103 HOH HOH A . 
D 4 HOH 248 648 181 HOH HOH A . 
D 4 HOH 249 649 230 HOH HOH A . 
D 4 HOH 250 650 236 HOH HOH A . 
D 4 HOH 251 651 121 HOH HOH A . 
D 4 HOH 252 652 276 HOH HOH A . 
D 4 HOH 253 653 188 HOH HOH A . 
D 4 HOH 254 654 220 HOH HOH A . 
D 4 HOH 255 655 77  HOH HOH A . 
D 4 HOH 256 656 158 HOH HOH A . 
D 4 HOH 257 657 219 HOH HOH A . 
D 4 HOH 258 658 150 HOH HOH A . 
D 4 HOH 259 659 296 HOH HOH A . 
D 4 HOH 260 660 56  HOH HOH A . 
D 4 HOH 261 661 274 HOH HOH A . 
D 4 HOH 262 662 259 HOH HOH A . 
D 4 HOH 263 663 134 HOH HOH A . 
D 4 HOH 264 664 222 HOH HOH A . 
D 4 HOH 265 665 242 HOH HOH A . 
D 4 HOH 266 666 203 HOH HOH A . 
D 4 HOH 267 667 128 HOH HOH A . 
D 4 HOH 268 668 185 HOH HOH A . 
D 4 HOH 269 669 184 HOH HOH A . 
D 4 HOH 270 670 249 HOH HOH A . 
D 4 HOH 271 671 182 HOH HOH A . 
D 4 HOH 272 672 257 HOH HOH A . 
D 4 HOH 273 673 297 HOH HOH A . 
D 4 HOH 274 674 141 HOH HOH A . 
D 4 HOH 275 675 223 HOH HOH A . 
D 4 HOH 276 676 294 HOH HOH A . 
D 4 HOH 277 677 147 HOH HOH A . 
D 4 HOH 278 678 161 HOH HOH A . 
D 4 HOH 279 679 79  HOH HOH A . 
D 4 HOH 280 680 209 HOH HOH A . 
D 4 HOH 281 681 138 HOH HOH A . 
D 4 HOH 282 682 208 HOH HOH A . 
D 4 HOH 283 683 221 HOH HOH A . 
D 4 HOH 284 684 170 HOH HOH A . 
D 4 HOH 285 685 192 HOH HOH A . 
D 4 HOH 286 686 232 HOH HOH A . 
D 4 HOH 287 687 5   HOH HOH A . 
D 4 HOH 288 688 229 HOH HOH A . 
D 4 HOH 289 689 1   HOH HOH A . 
D 4 HOH 290 690 248 HOH HOH A . 
D 4 HOH 291 691 263 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASP 3   ? CG  ? A ASP 3   CG  
2  1 Y 1 A ASP 3   ? OD1 ? A ASP 3   OD1 
3  1 Y 1 A ASP 3   ? OD2 ? A ASP 3   OD2 
4  1 Y 1 A LYS 5   ? CG  ? A LYS 5   CG  
5  1 Y 1 A LYS 5   ? CD  ? A LYS 5   CD  
6  1 Y 1 A LYS 5   ? CE  ? A LYS 5   CE  
7  1 Y 1 A LYS 5   ? NZ  ? A LYS 5   NZ  
8  1 Y 1 A GLU 10  ? CG  ? A GLU 10  CG  
9  1 Y 1 A GLU 10  ? CD  ? A GLU 10  CD  
10 1 Y 1 A GLU 10  ? OE1 ? A GLU 10  OE1 
11 1 Y 1 A GLU 10  ? OE2 ? A GLU 10  OE2 
12 1 Y 1 A LYS 101 ? CG  ? A LYS 101 CG  
13 1 Y 1 A LYS 101 ? CD  ? A LYS 101 CD  
14 1 Y 1 A LYS 101 ? CE  ? A LYS 101 CE  
15 1 Y 1 A LYS 101 ? NZ  ? A LYS 101 NZ  
16 1 Y 1 A LYS 105 ? CG  ? A LYS 105 CG  
17 1 Y 1 A LYS 105 ? CD  ? A LYS 105 CD  
18 1 Y 1 A LYS 105 ? CE  ? A LYS 105 CE  
19 1 Y 1 A LYS 105 ? NZ  ? A LYS 105 NZ  
20 1 Y 1 A LYS 158 ? CG  ? A LYS 158 CG  
21 1 Y 1 A LYS 158 ? CD  ? A LYS 158 CD  
22 1 Y 1 A LYS 158 ? CE  ? A LYS 158 CE  
23 1 Y 1 A LYS 158 ? NZ  ? A LYS 158 NZ  
24 1 Y 1 A LYS 218 ? CG  ? A LYS 218 CG  
25 1 Y 1 A LYS 218 ? CD  ? A LYS 218 CD  
26 1 Y 1 A LYS 218 ? CE  ? A LYS 218 CE  
27 1 Y 1 A LYS 218 ? NZ  ? A LYS 218 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.21.1_5286 1 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .           2 
? 'data processing' ? ? ? ? ? ? ? ? ? ? ? AutoProcess ? ? ? .           3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MSU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.225 
_cell.length_a_esd                 ? 
_cell.length_b                     74.225 
_cell.length_b_esd                 ? 
_cell.length_c                     107.712 
_cell.length_c_esd                 ? 
_cell.volume                       593423.175 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MSU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                95 
_symmetry.space_group_name_Hall            'P 4cw 2c' 
_symmetry.space_group_name_H-M             'P 43 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MSU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.82 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.31 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M MES:NaOH, pH 6.5 
10% w/v PEG4000
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-06-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 23-ID-D' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   23-ID-D 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          21.53 
_reflns.entry_id                                       9MSU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.56 
_reflns.d_resolution_low                               37.59 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     43441 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.50 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.20 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.04946 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.56 
_reflns_shell.d_res_low                                     1.6 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.72 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3007 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.866 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.72 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.532 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.21 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MSU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.56 
_refine.ls_d_res_low                             37.59 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     43351 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  41353 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.5 
_refine.ls_percent_reflns_R_free                 4.61 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1794 
_refine.ls_R_factor_R_free                       0.1977 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1780 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.3443 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1706 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.56 
_refine_hist.d_res_low                        37.59 
_refine_hist.number_atoms_solvent             291 
_refine_hist.number_atoms_total               2014 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1689 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0171  ? 1805 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.4433  ? 2451 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0804  ? 279  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0119  ? 318  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.0181 ? 677  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.56 1.60  . . 139 2868 98.75  . . . . 0.2587 . . . . . . . . . . . 0.3053 
'X-RAY DIFFRACTION' 1.60 1.64  . . 141 2924 100.00 . . . . 0.2335 . . . . . . . . . . . 0.2405 
'X-RAY DIFFRACTION' 1.64 1.69  . . 141 2930 100.00 . . . . 0.2146 . . . . . . . . . . . 0.2529 
'X-RAY DIFFRACTION' 1.69 1.75  . . 142 2917 99.97  . . . . 0.1959 . . . . . . . . . . . 0.2138 
'X-RAY DIFFRACTION' 1.75 1.81  . . 141 2925 100.00 . . . . 0.1942 . . . . . . . . . . . 0.2384 
'X-RAY DIFFRACTION' 1.81 1.88  . . 141 2907 99.93  . . . . 0.2009 . . . . . . . . . . . 0.2325 
'X-RAY DIFFRACTION' 1.88 1.97  . . 141 2919 99.29  . . . . 0.2006 . . . . . . . . . . . 0.2359 
'X-RAY DIFFRACTION' 1.97 2.07  . . 143 2954 100.00 . . . . 0.1832 . . . . . . . . . . . 0.2386 
'X-RAY DIFFRACTION' 2.07 2.20  . . 142 2940 100.00 . . . . 0.1761 . . . . . . . . . . . 0.1813 
'X-RAY DIFFRACTION' 2.20 2.37  . . 144 2967 99.97  . . . . 0.1726 . . . . . . . . . . . 0.1869 
'X-RAY DIFFRACTION' 2.37 2.61  . . 144 2970 99.87  . . . . 0.1697 . . . . . . . . . . . 0.1842 
'X-RAY DIFFRACTION' 2.61 2.98  . . 144 2992 99.40  . . . . 0.1672 . . . . . . . . . . . 0.1671 
'X-RAY DIFFRACTION' 2.98 3.76  . . 148 3041 99.97  . . . . 0.1606 . . . . . . . . . . . 0.2007 
'X-RAY DIFFRACTION' 3.76 37.59 . . 149 3099 96.29  . . . . 0.1790 . . . . . . . . . . . 0.1848 
# 
_struct.entry_id                     9MSU 
_struct.title                        'Candida albicans Hsp90 nucleotide binding domain in complex with BX2819' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MSU 
_struct_keywords.text            'Inhibitor complex, CHAPERONE, CHAPERONE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   CHAPERONE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HSP90_CANAL 
_struct_ref.pdbx_db_accession          P46598 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEK
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MSU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 218 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P46598 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  218 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       218 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MSU ASN A 219 ? UNP P46598 ? ? 'expression tag' 219 1  
1 9MSU LEU A 220 ? UNP P46598 ? ? 'expression tag' 220 2  
1 9MSU TYR A 221 ? UNP P46598 ? ? 'expression tag' 221 3  
1 9MSU PHE A 222 ? UNP P46598 ? ? 'expression tag' 222 4  
1 9MSU GLN A 223 ? UNP P46598 ? ? 'expression tag' 223 5  
1 9MSU SER A 224 ? UNP P46598 ? ? 'expression tag' 224 6  
1 9MSU GLY A 225 ? UNP P46598 ? ? 'expression tag' 225 7  
1 9MSU SER A 226 ? UNP P46598 ? ? 'expression tag' 226 8  
1 9MSU HIS A 227 ? UNP P46598 ? ? 'expression tag' 227 9  
1 9MSU HIS A 228 ? UNP P46598 ? ? 'expression tag' 228 10 
1 9MSU HIS A 229 ? UNP P46598 ? ? 'expression tag' 229 11 
1 9MSU HIS A 230 ? UNP P46598 ? ? 'expression tag' 230 12 
1 9MSU HIS A 231 ? UNP P46598 ? ? 'expression tag' 231 13 
1 9MSU HIS A 232 ? UNP P46598 ? ? 'expression tag' 232 14 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 12  ? THR A 25  ? THR A 12  THR A 25  1 ? 14 
HELX_P HELX_P2 AA2 GLU A 31  ? ASP A 55  ? GLU A 31  ASP A 55  1 ? 25 
HELX_P HELX_P3 AA3 PRO A 56  ? GLU A 60  ? PRO A 56  GLU A 60  5 ? 5  
HELX_P HELX_P4 AA4 THR A 88  ? LEU A 96  ? THR A 88  LEU A 96  1 ? 9  
HELX_P HELX_P5 AA5 LYS A 101 ? GLY A 114 ? LYS A 101 GLY A 114 1 ? 14 
HELX_P HELX_P6 AA6 ASP A 116 ? GLY A 124 ? ASP A 116 GLY A 124 5 ? 9  
HELX_P HELX_P7 AA7 VAL A 125 ? LEU A 132 ? VAL A 125 LEU A 132 5 ? 8  
HELX_P HELX_P8 AA8 GLN A 184 ? LEU A 188 ? GLN A 184 LEU A 188 5 ? 5  
HELX_P HELX_P9 AA9 GLU A 189 ? SER A 201 ? GLU A 189 SER A 201 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   8 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 6   ? GLU A 10  ? VAL A 6   GLU A 10  
AA1 2 LYS A 158 ? LEU A 163 ? LYS A 158 LEU A 163 
AA1 3 TYR A 149 ? SER A 153 ? TYR A 149 SER A 153 
AA1 4 ALA A 134 ? LYS A 142 ? ALA A 134 LYS A 142 
AA1 5 GLY A 173 ? LEU A 180 ? GLY A 173 LEU A 180 
AA1 6 VAL A 77  ? ASP A 82  ? VAL A 77  ASP A 82  
AA1 7 ILE A 67  ? GLN A 72  ? ILE A 67  GLN A 72  
AA1 8 ILE A 208 ? LEU A 210 ? ILE A 208 LEU A 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 9   ? N HIS A 9   O PHE A 159 ? O PHE A 159 
AA1 2 3 O THR A 162 ? O THR A 162 N VAL A 150 ? N VAL A 150 
AA1 3 4 O TRP A 151 ? O TRP A 151 N VAL A 139 ? N VAL A 139 
AA1 4 5 N GLN A 138 ? N GLN A 138 O ARG A 177 ? O ARG A 177 
AA1 5 6 O LEU A 178 ? O LEU A 178 N LEU A 78  ? N LEU A 78  
AA1 6 7 O ARG A 81  ? O ARG A 81  N ARG A 68  ? N ARG A 68  
AA1 7 8 N ILE A 67  ? N ILE A 67  O GLN A 209 ? O GLN A 209 
# 
_pdbx_entry_details.entry_id                   9MSU 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 401 ? ? O A HOH 580 ? ? 2.10 
2 1 O   A HOH 472 ? ? O A HOH 637 ? ? 2.11 
3 1 OD1 A ASP 145 ? ? O A HOH 401 ? ? 2.15 
4 1 O   A HOH 433 ? ? O A HOH 665 ? ? 2.18 
5 1 O   A HOH 665 ? ? O A HOH 670 ? ? 2.18 
6 1 O   A HOH 632 ? ? O A HOH 645 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 29  ? ? -100.17 61.59 
2 1 GLU A 62  ? ? -167.99 95.30 
3 1 GLU A 62  ? ? -167.76 94.71 
4 1 PHE A 203 ? ? -105.89 76.29 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 583 ? D HOH . 
2 1 A HOH 606 ? D HOH . 
3 1 A HOH 609 ? D HOH . 
4 1 A HOH 689 ? D HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z        
2 -y,x,z+3/4   
3 y,-x,z+1/4   
4 x,-y,-z+1/2  
5 -x,y,-z      
6 -x,-y,z+1/2  
7 y,x,-z+1/4   
8 -y,-x,-z+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ASN 219 ? A ASN 219 
4  1 Y 1 A LEU 220 ? A LEU 220 
5  1 Y 1 A TYR 221 ? A TYR 221 
6  1 Y 1 A PHE 222 ? A PHE 222 
7  1 Y 1 A GLN 223 ? A GLN 223 
8  1 Y 1 A SER 224 ? A SER 224 
9  1 Y 1 A GLY 225 ? A GLY 225 
10 1 Y 1 A SER 226 ? A SER 226 
11 1 Y 1 A HIS 227 ? A HIS 227 
12 1 Y 1 A HIS 228 ? A HIS 228 
13 1 Y 1 A HIS 229 ? A HIS 229 
14 1 Y 1 A HIS 230 ? A HIS 230 
15 1 Y 1 A HIS 231 ? A HIS 231 
16 1 Y 1 A HIS 232 ? A HIS 232 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
819 C1   C N N 1   
819 C2   C N N 2   
819 O3   O N N 3   
819 C4   C N N 4   
819 O5   O N N 5   
819 N6   N N N 6   
819 C8   C N N 7   
819 C9   C Y N 8   
819 C12  C Y N 9   
819 C13  C Y N 10  
819 C10  C Y N 11  
819 C11  C Y N 12  
819 C14  C Y N 13  
819 N15  N Y N 14  
819 C16  C Y N 15  
819 S17  S N N 16  
819 N18  N Y N 17  
819 N20  N Y N 18  
819 C21  C Y N 19  
819 C22  C Y N 20  
819 C23  C Y N 21  
819 C24  C Y N 22  
819 C25  C N N 23  
819 C27  C N N 24  
819 C26  C N N 25  
819 C28  C Y N 26  
819 O29  O N N 27  
819 C31  C Y N 28  
819 C32  C Y N 29  
819 O33  O N N 30  
819 H1   H N N 31  
819 H1A  H N N 32  
819 H1B  H N N 33  
819 H2   H N N 34  
819 H2A  H N N 35  
819 HN6  H N N 36  
819 H8   H N N 37  
819 H8A  H N N 38  
819 H12  H N N 39  
819 H13  H N N 40  
819 H10  H N N 41  
819 H11  H N N 42  
819 HS17 H N N 43  
819 H23  H N N 44  
819 H25  H N N 45  
819 H27  H N N 46  
819 H27A H N N 47  
819 H27B H N N 48  
819 H26  H N N 49  
819 H26A H N N 50  
819 H26B H N N 51  
819 HO29 H N N 52  
819 H31  H N N 53  
819 HO33 H N N 54  
ALA N    N N N 55  
ALA CA   C N S 56  
ALA C    C N N 57  
ALA O    O N N 58  
ALA CB   C N N 59  
ALA OXT  O N N 60  
ALA H    H N N 61  
ALA H2   H N N 62  
ALA HA   H N N 63  
ALA HB1  H N N 64  
ALA HB2  H N N 65  
ALA HB3  H N N 66  
ALA HXT  H N N 67  
ARG N    N N N 68  
ARG CA   C N S 69  
ARG C    C N N 70  
ARG O    O N N 71  
ARG CB   C N N 72  
ARG CG   C N N 73  
ARG CD   C N N 74  
ARG NE   N N N 75  
ARG CZ   C N N 76  
ARG NH1  N N N 77  
ARG NH2  N N N 78  
ARG OXT  O N N 79  
ARG H    H N N 80  
ARG H2   H N N 81  
ARG HA   H N N 82  
ARG HB2  H N N 83  
ARG HB3  H N N 84  
ARG HG2  H N N 85  
ARG HG3  H N N 86  
ARG HD2  H N N 87  
ARG HD3  H N N 88  
ARG HE   H N N 89  
ARG HH11 H N N 90  
ARG HH12 H N N 91  
ARG HH21 H N N 92  
ARG HH22 H N N 93  
ARG HXT  H N N 94  
ASN N    N N N 95  
ASN CA   C N S 96  
ASN C    C N N 97  
ASN O    O N N 98  
ASN CB   C N N 99  
ASN CG   C N N 100 
ASN OD1  O N N 101 
ASN ND2  N N N 102 
ASN OXT  O N N 103 
ASN H    H N N 104 
ASN H2   H N N 105 
ASN HA   H N N 106 
ASN HB2  H N N 107 
ASN HB3  H N N 108 
ASN HD21 H N N 109 
ASN HD22 H N N 110 
ASN HXT  H N N 111 
ASP N    N N N 112 
ASP CA   C N S 113 
ASP C    C N N 114 
ASP O    O N N 115 
ASP CB   C N N 116 
ASP CG   C N N 117 
ASP OD1  O N N 118 
ASP OD2  O N N 119 
ASP OXT  O N N 120 
ASP H    H N N 121 
ASP H2   H N N 122 
ASP HA   H N N 123 
ASP HB2  H N N 124 
ASP HB3  H N N 125 
ASP HD2  H N N 126 
ASP HXT  H N N 127 
EDO C1   C N N 128 
EDO O1   O N N 129 
EDO C2   C N N 130 
EDO O2   O N N 131 
EDO H11  H N N 132 
EDO H12  H N N 133 
EDO HO1  H N N 134 
EDO H21  H N N 135 
EDO H22  H N N 136 
EDO HO2  H N N 137 
GLN N    N N N 138 
GLN CA   C N S 139 
GLN C    C N N 140 
GLN O    O N N 141 
GLN CB   C N N 142 
GLN CG   C N N 143 
GLN CD   C N N 144 
GLN OE1  O N N 145 
GLN NE2  N N N 146 
GLN OXT  O N N 147 
GLN H    H N N 148 
GLN H2   H N N 149 
GLN HA   H N N 150 
GLN HB2  H N N 151 
GLN HB3  H N N 152 
GLN HG2  H N N 153 
GLN HG3  H N N 154 
GLN HE21 H N N 155 
GLN HE22 H N N 156 
GLN HXT  H N N 157 
GLU N    N N N 158 
GLU CA   C N S 159 
GLU C    C N N 160 
GLU O    O N N 161 
GLU CB   C N N 162 
GLU CG   C N N 163 
GLU CD   C N N 164 
GLU OE1  O N N 165 
GLU OE2  O N N 166 
GLU OXT  O N N 167 
GLU H    H N N 168 
GLU H2   H N N 169 
GLU HA   H N N 170 
GLU HB2  H N N 171 
GLU HB3  H N N 172 
GLU HG2  H N N 173 
GLU HG3  H N N 174 
GLU HE2  H N N 175 
GLU HXT  H N N 176 
GLY N    N N N 177 
GLY CA   C N N 178 
GLY C    C N N 179 
GLY O    O N N 180 
GLY OXT  O N N 181 
GLY H    H N N 182 
GLY H2   H N N 183 
GLY HA2  H N N 184 
GLY HA3  H N N 185 
GLY HXT  H N N 186 
HIS N    N N N 187 
HIS CA   C N S 188 
HIS C    C N N 189 
HIS O    O N N 190 
HIS CB   C N N 191 
HIS CG   C Y N 192 
HIS ND1  N Y N 193 
HIS CD2  C Y N 194 
HIS CE1  C Y N 195 
HIS NE2  N Y N 196 
HIS OXT  O N N 197 
HIS H    H N N 198 
HIS H2   H N N 199 
HIS HA   H N N 200 
HIS HB2  H N N 201 
HIS HB3  H N N 202 
HIS HD1  H N N 203 
HIS HD2  H N N 204 
HIS HE1  H N N 205 
HIS HE2  H N N 206 
HIS HXT  H N N 207 
HOH O    O N N 208 
HOH H1   H N N 209 
HOH H2   H N N 210 
ILE N    N N N 211 
ILE CA   C N S 212 
ILE C    C N N 213 
ILE O    O N N 214 
ILE CB   C N S 215 
ILE CG1  C N N 216 
ILE CG2  C N N 217 
ILE CD1  C N N 218 
ILE OXT  O N N 219 
ILE H    H N N 220 
ILE H2   H N N 221 
ILE HA   H N N 222 
ILE HB   H N N 223 
ILE HG12 H N N 224 
ILE HG13 H N N 225 
ILE HG21 H N N 226 
ILE HG22 H N N 227 
ILE HG23 H N N 228 
ILE HD11 H N N 229 
ILE HD12 H N N 230 
ILE HD13 H N N 231 
ILE HXT  H N N 232 
LEU N    N N N 233 
LEU CA   C N S 234 
LEU C    C N N 235 
LEU O    O N N 236 
LEU CB   C N N 237 
LEU CG   C N N 238 
LEU CD1  C N N 239 
LEU CD2  C N N 240 
LEU OXT  O N N 241 
LEU H    H N N 242 
LEU H2   H N N 243 
LEU HA   H N N 244 
LEU HB2  H N N 245 
LEU HB3  H N N 246 
LEU HG   H N N 247 
LEU HD11 H N N 248 
LEU HD12 H N N 249 
LEU HD13 H N N 250 
LEU HD21 H N N 251 
LEU HD22 H N N 252 
LEU HD23 H N N 253 
LEU HXT  H N N 254 
LYS N    N N N 255 
LYS CA   C N S 256 
LYS C    C N N 257 
LYS O    O N N 258 
LYS CB   C N N 259 
LYS CG   C N N 260 
LYS CD   C N N 261 
LYS CE   C N N 262 
LYS NZ   N N N 263 
LYS OXT  O N N 264 
LYS H    H N N 265 
LYS H2   H N N 266 
LYS HA   H N N 267 
LYS HB2  H N N 268 
LYS HB3  H N N 269 
LYS HG2  H N N 270 
LYS HG3  H N N 271 
LYS HD2  H N N 272 
LYS HD3  H N N 273 
LYS HE2  H N N 274 
LYS HE3  H N N 275 
LYS HZ1  H N N 276 
LYS HZ2  H N N 277 
LYS HZ3  H N N 278 
LYS HXT  H N N 279 
MET N    N N N 280 
MET CA   C N S 281 
MET C    C N N 282 
MET O    O N N 283 
MET CB   C N N 284 
MET CG   C N N 285 
MET SD   S N N 286 
MET CE   C N N 287 
MET OXT  O N N 288 
MET H    H N N 289 
MET H2   H N N 290 
MET HA   H N N 291 
MET HB2  H N N 292 
MET HB3  H N N 293 
MET HG2  H N N 294 
MET HG3  H N N 295 
MET HE1  H N N 296 
MET HE2  H N N 297 
MET HE3  H N N 298 
MET HXT  H N N 299 
PHE N    N N N 300 
PHE CA   C N S 301 
PHE C    C N N 302 
PHE O    O N N 303 
PHE CB   C N N 304 
PHE CG   C Y N 305 
PHE CD1  C Y N 306 
PHE CD2  C Y N 307 
PHE CE1  C Y N 308 
PHE CE2  C Y N 309 
PHE CZ   C Y N 310 
PHE OXT  O N N 311 
PHE H    H N N 312 
PHE H2   H N N 313 
PHE HA   H N N 314 
PHE HB2  H N N 315 
PHE HB3  H N N 316 
PHE HD1  H N N 317 
PHE HD2  H N N 318 
PHE HE1  H N N 319 
PHE HE2  H N N 320 
PHE HZ   H N N 321 
PHE HXT  H N N 322 
PRO N    N N N 323 
PRO CA   C N S 324 
PRO C    C N N 325 
PRO O    O N N 326 
PRO CB   C N N 327 
PRO CG   C N N 328 
PRO CD   C N N 329 
PRO OXT  O N N 330 
PRO H    H N N 331 
PRO HA   H N N 332 
PRO HB2  H N N 333 
PRO HB3  H N N 334 
PRO HG2  H N N 335 
PRO HG3  H N N 336 
PRO HD2  H N N 337 
PRO HD3  H N N 338 
PRO HXT  H N N 339 
SER N    N N N 340 
SER CA   C N S 341 
SER C    C N N 342 
SER O    O N N 343 
SER CB   C N N 344 
SER OG   O N N 345 
SER OXT  O N N 346 
SER H    H N N 347 
SER H2   H N N 348 
SER HA   H N N 349 
SER HB2  H N N 350 
SER HB3  H N N 351 
SER HG   H N N 352 
SER HXT  H N N 353 
THR N    N N N 354 
THR CA   C N S 355 
THR C    C N N 356 
THR O    O N N 357 
THR CB   C N R 358 
THR OG1  O N N 359 
THR CG2  C N N 360 
THR OXT  O N N 361 
THR H    H N N 362 
THR H2   H N N 363 
THR HA   H N N 364 
THR HB   H N N 365 
THR HG1  H N N 366 
THR HG21 H N N 367 
THR HG22 H N N 368 
THR HG23 H N N 369 
THR HXT  H N N 370 
TRP N    N N N 371 
TRP CA   C N S 372 
TRP C    C N N 373 
TRP O    O N N 374 
TRP CB   C N N 375 
TRP CG   C Y N 376 
TRP CD1  C Y N 377 
TRP CD2  C Y N 378 
TRP NE1  N Y N 379 
TRP CE2  C Y N 380 
TRP CE3  C Y N 381 
TRP CZ2  C Y N 382 
TRP CZ3  C Y N 383 
TRP CH2  C Y N 384 
TRP OXT  O N N 385 
TRP H    H N N 386 
TRP H2   H N N 387 
TRP HA   H N N 388 
TRP HB2  H N N 389 
TRP HB3  H N N 390 
TRP HD1  H N N 391 
TRP HE1  H N N 392 
TRP HE3  H N N 393 
TRP HZ2  H N N 394 
TRP HZ3  H N N 395 
TRP HH2  H N N 396 
TRP HXT  H N N 397 
TYR N    N N N 398 
TYR CA   C N S 399 
TYR C    C N N 400 
TYR O    O N N 401 
TYR CB   C N N 402 
TYR CG   C Y N 403 
TYR CD1  C Y N 404 
TYR CD2  C Y N 405 
TYR CE1  C Y N 406 
TYR CE2  C Y N 407 
TYR CZ   C Y N 408 
TYR OH   O N N 409 
TYR OXT  O N N 410 
TYR H    H N N 411 
TYR H2   H N N 412 
TYR HA   H N N 413 
TYR HB2  H N N 414 
TYR HB3  H N N 415 
TYR HD1  H N N 416 
TYR HD2  H N N 417 
TYR HE1  H N N 418 
TYR HE2  H N N 419 
TYR HH   H N N 420 
TYR HXT  H N N 421 
VAL N    N N N 422 
VAL CA   C N S 423 
VAL C    C N N 424 
VAL O    O N N 425 
VAL CB   C N N 426 
VAL CG1  C N N 427 
VAL CG2  C N N 428 
VAL OXT  O N N 429 
VAL H    H N N 430 
VAL H2   H N N 431 
VAL HA   H N N 432 
VAL HB   H N N 433 
VAL HG11 H N N 434 
VAL HG12 H N N 435 
VAL HG13 H N N 436 
VAL HG21 H N N 437 
VAL HG22 H N N 438 
VAL HG23 H N N 439 
VAL HXT  H N N 440 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
819 C1  C2   sing N N 1   
819 C2  O3   sing N N 2   
819 O3  C4   sing N N 3   
819 C4  O5   doub N N 4   
819 C4  N6   sing N N 5   
819 N6  C8   sing N N 6   
819 C8  C9   sing N N 7   
819 C9  C12  doub Y N 8   
819 C9  C10  sing Y N 9   
819 C12 C13  sing Y N 10  
819 C13 C14  doub Y N 11  
819 C10 C11  doub Y N 12  
819 C11 C14  sing Y N 13  
819 C14 N15  sing Y N 14  
819 N15 C16  sing Y N 15  
819 N15 C21  sing Y N 16  
819 C16 S17  sing N N 17  
819 C16 N18  doub Y N 18  
819 N18 N20  sing Y N 19  
819 N20 C21  doub Y N 20  
819 C21 C22  sing Y N 21  
819 C22 C23  doub Y N 22  
819 C22 C32  sing Y N 23  
819 C23 C24  sing Y N 24  
819 C24 C25  sing N N 25  
819 C24 C28  doub Y N 26  
819 C25 C27  sing N N 27  
819 C25 C26  sing N N 28  
819 C28 O29  sing N N 29  
819 C28 C31  sing Y N 30  
819 C31 C32  doub Y N 31  
819 C32 O33  sing N N 32  
819 C1  H1   sing N N 33  
819 C1  H1A  sing N N 34  
819 C1  H1B  sing N N 35  
819 C2  H2   sing N N 36  
819 C2  H2A  sing N N 37  
819 N6  HN6  sing N N 38  
819 C8  H8   sing N N 39  
819 C8  H8A  sing N N 40  
819 C12 H12  sing N N 41  
819 C13 H13  sing N N 42  
819 C10 H10  sing N N 43  
819 C11 H11  sing N N 44  
819 S17 HS17 sing N N 45  
819 C23 H23  sing N N 46  
819 C25 H25  sing N N 47  
819 C27 H27  sing N N 48  
819 C27 H27A sing N N 49  
819 C27 H27B sing N N 50  
819 C26 H26  sing N N 51  
819 C26 H26A sing N N 52  
819 C26 H26B sing N N 53  
819 O29 HO29 sing N N 54  
819 C31 H31  sing N N 55  
819 O33 HO33 sing N N 56  
ALA N   CA   sing N N 57  
ALA N   H    sing N N 58  
ALA N   H2   sing N N 59  
ALA CA  C    sing N N 60  
ALA CA  CB   sing N N 61  
ALA CA  HA   sing N N 62  
ALA C   O    doub N N 63  
ALA C   OXT  sing N N 64  
ALA CB  HB1  sing N N 65  
ALA CB  HB2  sing N N 66  
ALA CB  HB3  sing N N 67  
ALA OXT HXT  sing N N 68  
ARG N   CA   sing N N 69  
ARG N   H    sing N N 70  
ARG N   H2   sing N N 71  
ARG CA  C    sing N N 72  
ARG CA  CB   sing N N 73  
ARG CA  HA   sing N N 74  
ARG C   O    doub N N 75  
ARG C   OXT  sing N N 76  
ARG CB  CG   sing N N 77  
ARG CB  HB2  sing N N 78  
ARG CB  HB3  sing N N 79  
ARG CG  CD   sing N N 80  
ARG CG  HG2  sing N N 81  
ARG CG  HG3  sing N N 82  
ARG CD  NE   sing N N 83  
ARG CD  HD2  sing N N 84  
ARG CD  HD3  sing N N 85  
ARG NE  CZ   sing N N 86  
ARG NE  HE   sing N N 87  
ARG CZ  NH1  sing N N 88  
ARG CZ  NH2  doub N N 89  
ARG NH1 HH11 sing N N 90  
ARG NH1 HH12 sing N N 91  
ARG NH2 HH21 sing N N 92  
ARG NH2 HH22 sing N N 93  
ARG OXT HXT  sing N N 94  
ASN N   CA   sing N N 95  
ASN N   H    sing N N 96  
ASN N   H2   sing N N 97  
ASN CA  C    sing N N 98  
ASN CA  CB   sing N N 99  
ASN CA  HA   sing N N 100 
ASN C   O    doub N N 101 
ASN C   OXT  sing N N 102 
ASN CB  CG   sing N N 103 
ASN CB  HB2  sing N N 104 
ASN CB  HB3  sing N N 105 
ASN CG  OD1  doub N N 106 
ASN CG  ND2  sing N N 107 
ASN ND2 HD21 sing N N 108 
ASN ND2 HD22 sing N N 109 
ASN OXT HXT  sing N N 110 
ASP N   CA   sing N N 111 
ASP N   H    sing N N 112 
ASP N   H2   sing N N 113 
ASP CA  C    sing N N 114 
ASP CA  CB   sing N N 115 
ASP CA  HA   sing N N 116 
ASP C   O    doub N N 117 
ASP C   OXT  sing N N 118 
ASP CB  CG   sing N N 119 
ASP CB  HB2  sing N N 120 
ASP CB  HB3  sing N N 121 
ASP CG  OD1  doub N N 122 
ASP CG  OD2  sing N N 123 
ASP OD2 HD2  sing N N 124 
ASP OXT HXT  sing N N 125 
EDO C1  O1   sing N N 126 
EDO C1  C2   sing N N 127 
EDO C1  H11  sing N N 128 
EDO C1  H12  sing N N 129 
EDO O1  HO1  sing N N 130 
EDO C2  O2   sing N N 131 
EDO C2  H21  sing N N 132 
EDO C2  H22  sing N N 133 
EDO O2  HO2  sing N N 134 
GLN N   CA   sing N N 135 
GLN N   H    sing N N 136 
GLN N   H2   sing N N 137 
GLN CA  C    sing N N 138 
GLN CA  CB   sing N N 139 
GLN CA  HA   sing N N 140 
GLN C   O    doub N N 141 
GLN C   OXT  sing N N 142 
GLN CB  CG   sing N N 143 
GLN CB  HB2  sing N N 144 
GLN CB  HB3  sing N N 145 
GLN CG  CD   sing N N 146 
GLN CG  HG2  sing N N 147 
GLN CG  HG3  sing N N 148 
GLN CD  OE1  doub N N 149 
GLN CD  NE2  sing N N 150 
GLN NE2 HE21 sing N N 151 
GLN NE2 HE22 sing N N 152 
GLN OXT HXT  sing N N 153 
GLU N   CA   sing N N 154 
GLU N   H    sing N N 155 
GLU N   H2   sing N N 156 
GLU CA  C    sing N N 157 
GLU CA  CB   sing N N 158 
GLU CA  HA   sing N N 159 
GLU C   O    doub N N 160 
GLU C   OXT  sing N N 161 
GLU CB  CG   sing N N 162 
GLU CB  HB2  sing N N 163 
GLU CB  HB3  sing N N 164 
GLU CG  CD   sing N N 165 
GLU CG  HG2  sing N N 166 
GLU CG  HG3  sing N N 167 
GLU CD  OE1  doub N N 168 
GLU CD  OE2  sing N N 169 
GLU OE2 HE2  sing N N 170 
GLU OXT HXT  sing N N 171 
GLY N   CA   sing N N 172 
GLY N   H    sing N N 173 
GLY N   H2   sing N N 174 
GLY CA  C    sing N N 175 
GLY CA  HA2  sing N N 176 
GLY CA  HA3  sing N N 177 
GLY C   O    doub N N 178 
GLY C   OXT  sing N N 179 
GLY OXT HXT  sing N N 180 
HIS N   CA   sing N N 181 
HIS N   H    sing N N 182 
HIS N   H2   sing N N 183 
HIS CA  C    sing N N 184 
HIS CA  CB   sing N N 185 
HIS CA  HA   sing N N 186 
HIS C   O    doub N N 187 
HIS C   OXT  sing N N 188 
HIS CB  CG   sing N N 189 
HIS CB  HB2  sing N N 190 
HIS CB  HB3  sing N N 191 
HIS CG  ND1  sing Y N 192 
HIS CG  CD2  doub Y N 193 
HIS ND1 CE1  doub Y N 194 
HIS ND1 HD1  sing N N 195 
HIS CD2 NE2  sing Y N 196 
HIS CD2 HD2  sing N N 197 
HIS CE1 NE2  sing Y N 198 
HIS CE1 HE1  sing N N 199 
HIS NE2 HE2  sing N N 200 
HIS OXT HXT  sing N N 201 
HOH O   H1   sing N N 202 
HOH O   H2   sing N N 203 
ILE N   CA   sing N N 204 
ILE N   H    sing N N 205 
ILE N   H2   sing N N 206 
ILE CA  C    sing N N 207 
ILE CA  CB   sing N N 208 
ILE CA  HA   sing N N 209 
ILE C   O    doub N N 210 
ILE C   OXT  sing N N 211 
ILE CB  CG1  sing N N 212 
ILE CB  CG2  sing N N 213 
ILE CB  HB   sing N N 214 
ILE CG1 CD1  sing N N 215 
ILE CG1 HG12 sing N N 216 
ILE CG1 HG13 sing N N 217 
ILE CG2 HG21 sing N N 218 
ILE CG2 HG22 sing N N 219 
ILE CG2 HG23 sing N N 220 
ILE CD1 HD11 sing N N 221 
ILE CD1 HD12 sing N N 222 
ILE CD1 HD13 sing N N 223 
ILE OXT HXT  sing N N 224 
LEU N   CA   sing N N 225 
LEU N   H    sing N N 226 
LEU N   H2   sing N N 227 
LEU CA  C    sing N N 228 
LEU CA  CB   sing N N 229 
LEU CA  HA   sing N N 230 
LEU C   O    doub N N 231 
LEU C   OXT  sing N N 232 
LEU CB  CG   sing N N 233 
LEU CB  HB2  sing N N 234 
LEU CB  HB3  sing N N 235 
LEU CG  CD1  sing N N 236 
LEU CG  CD2  sing N N 237 
LEU CG  HG   sing N N 238 
LEU CD1 HD11 sing N N 239 
LEU CD1 HD12 sing N N 240 
LEU CD1 HD13 sing N N 241 
LEU CD2 HD21 sing N N 242 
LEU CD2 HD22 sing N N 243 
LEU CD2 HD23 sing N N 244 
LEU OXT HXT  sing N N 245 
LYS N   CA   sing N N 246 
LYS N   H    sing N N 247 
LYS N   H2   sing N N 248 
LYS CA  C    sing N N 249 
LYS CA  CB   sing N N 250 
LYS CA  HA   sing N N 251 
LYS C   O    doub N N 252 
LYS C   OXT  sing N N 253 
LYS CB  CG   sing N N 254 
LYS CB  HB2  sing N N 255 
LYS CB  HB3  sing N N 256 
LYS CG  CD   sing N N 257 
LYS CG  HG2  sing N N 258 
LYS CG  HG3  sing N N 259 
LYS CD  CE   sing N N 260 
LYS CD  HD2  sing N N 261 
LYS CD  HD3  sing N N 262 
LYS CE  NZ   sing N N 263 
LYS CE  HE2  sing N N 264 
LYS CE  HE3  sing N N 265 
LYS NZ  HZ1  sing N N 266 
LYS NZ  HZ2  sing N N 267 
LYS NZ  HZ3  sing N N 268 
LYS OXT HXT  sing N N 269 
MET N   CA   sing N N 270 
MET N   H    sing N N 271 
MET N   H2   sing N N 272 
MET CA  C    sing N N 273 
MET CA  CB   sing N N 274 
MET CA  HA   sing N N 275 
MET C   O    doub N N 276 
MET C   OXT  sing N N 277 
MET CB  CG   sing N N 278 
MET CB  HB2  sing N N 279 
MET CB  HB3  sing N N 280 
MET CG  SD   sing N N 281 
MET CG  HG2  sing N N 282 
MET CG  HG3  sing N N 283 
MET SD  CE   sing N N 284 
MET CE  HE1  sing N N 285 
MET CE  HE2  sing N N 286 
MET CE  HE3  sing N N 287 
MET OXT HXT  sing N N 288 
PHE N   CA   sing N N 289 
PHE N   H    sing N N 290 
PHE N   H2   sing N N 291 
PHE CA  C    sing N N 292 
PHE CA  CB   sing N N 293 
PHE CA  HA   sing N N 294 
PHE C   O    doub N N 295 
PHE C   OXT  sing N N 296 
PHE CB  CG   sing N N 297 
PHE CB  HB2  sing N N 298 
PHE CB  HB3  sing N N 299 
PHE CG  CD1  doub Y N 300 
PHE CG  CD2  sing Y N 301 
PHE CD1 CE1  sing Y N 302 
PHE CD1 HD1  sing N N 303 
PHE CD2 CE2  doub Y N 304 
PHE CD2 HD2  sing N N 305 
PHE CE1 CZ   doub Y N 306 
PHE CE1 HE1  sing N N 307 
PHE CE2 CZ   sing Y N 308 
PHE CE2 HE2  sing N N 309 
PHE CZ  HZ   sing N N 310 
PHE OXT HXT  sing N N 311 
PRO N   CA   sing N N 312 
PRO N   CD   sing N N 313 
PRO N   H    sing N N 314 
PRO CA  C    sing N N 315 
PRO CA  CB   sing N N 316 
PRO CA  HA   sing N N 317 
PRO C   O    doub N N 318 
PRO C   OXT  sing N N 319 
PRO CB  CG   sing N N 320 
PRO CB  HB2  sing N N 321 
PRO CB  HB3  sing N N 322 
PRO CG  CD   sing N N 323 
PRO CG  HG2  sing N N 324 
PRO CG  HG3  sing N N 325 
PRO CD  HD2  sing N N 326 
PRO CD  HD3  sing N N 327 
PRO OXT HXT  sing N N 328 
SER N   CA   sing N N 329 
SER N   H    sing N N 330 
SER N   H2   sing N N 331 
SER CA  C    sing N N 332 
SER CA  CB   sing N N 333 
SER CA  HA   sing N N 334 
SER C   O    doub N N 335 
SER C   OXT  sing N N 336 
SER CB  OG   sing N N 337 
SER CB  HB2  sing N N 338 
SER CB  HB3  sing N N 339 
SER OG  HG   sing N N 340 
SER OXT HXT  sing N N 341 
THR N   CA   sing N N 342 
THR N   H    sing N N 343 
THR N   H2   sing N N 344 
THR CA  C    sing N N 345 
THR CA  CB   sing N N 346 
THR CA  HA   sing N N 347 
THR C   O    doub N N 348 
THR C   OXT  sing N N 349 
THR CB  OG1  sing N N 350 
THR CB  CG2  sing N N 351 
THR CB  HB   sing N N 352 
THR OG1 HG1  sing N N 353 
THR CG2 HG21 sing N N 354 
THR CG2 HG22 sing N N 355 
THR CG2 HG23 sing N N 356 
THR OXT HXT  sing N N 357 
TRP N   CA   sing N N 358 
TRP N   H    sing N N 359 
TRP N   H2   sing N N 360 
TRP CA  C    sing N N 361 
TRP CA  CB   sing N N 362 
TRP CA  HA   sing N N 363 
TRP C   O    doub N N 364 
TRP C   OXT  sing N N 365 
TRP CB  CG   sing N N 366 
TRP CB  HB2  sing N N 367 
TRP CB  HB3  sing N N 368 
TRP CG  CD1  doub Y N 369 
TRP CG  CD2  sing Y N 370 
TRP CD1 NE1  sing Y N 371 
TRP CD1 HD1  sing N N 372 
TRP CD2 CE2  doub Y N 373 
TRP CD2 CE3  sing Y N 374 
TRP NE1 CE2  sing Y N 375 
TRP NE1 HE1  sing N N 376 
TRP CE2 CZ2  sing Y N 377 
TRP CE3 CZ3  doub Y N 378 
TRP CE3 HE3  sing N N 379 
TRP CZ2 CH2  doub Y N 380 
TRP CZ2 HZ2  sing N N 381 
TRP CZ3 CH2  sing Y N 382 
TRP CZ3 HZ3  sing N N 383 
TRP CH2 HH2  sing N N 384 
TRP OXT HXT  sing N N 385 
TYR N   CA   sing N N 386 
TYR N   H    sing N N 387 
TYR N   H2   sing N N 388 
TYR CA  C    sing N N 389 
TYR CA  CB   sing N N 390 
TYR CA  HA   sing N N 391 
TYR C   O    doub N N 392 
TYR C   OXT  sing N N 393 
TYR CB  CG   sing N N 394 
TYR CB  HB2  sing N N 395 
TYR CB  HB3  sing N N 396 
TYR CG  CD1  doub Y N 397 
TYR CG  CD2  sing Y N 398 
TYR CD1 CE1  sing Y N 399 
TYR CD1 HD1  sing N N 400 
TYR CD2 CE2  doub Y N 401 
TYR CD2 HD2  sing N N 402 
TYR CE1 CZ   doub Y N 403 
TYR CE1 HE1  sing N N 404 
TYR CE2 CZ   sing Y N 405 
TYR CE2 HE2  sing N N 406 
TYR CZ  OH   sing N N 407 
TYR OH  HH   sing N N 408 
TYR OXT HXT  sing N N 409 
VAL N   CA   sing N N 410 
VAL N   H    sing N N 411 
VAL N   H2   sing N N 412 
VAL CA  C    sing N N 413 
VAL CA  CB   sing N N 414 
VAL CA  HA   sing N N 415 
VAL C   O    doub N N 416 
VAL C   OXT  sing N N 417 
VAL CB  CG1  sing N N 418 
VAL CB  CG2  sing N N 419 
VAL CB  HB   sing N N 420 
VAL CG1 HG11 sing N N 421 
VAL CG1 HG12 sing N N 422 
VAL CG1 HG13 sing N N 423 
VAL CG2 HG21 sing N N 424 
VAL CG2 HG22 sing N N 425 
VAL CG2 HG23 sing N N 426 
VAL OXT HXT  sing N N 427 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' T32GM148376-01A1 1 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 1R35GM152079-01  2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6CJI 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 2 2' 
_space_group.name_Hall        'P 4cw 2c' 
_space_group.IT_number        95 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9MSU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013473 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013473 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009284 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASP A 1 3   ? 1.21500   -51.87900 3.72900   1.000 41.55000  ? 3   ASP A N    1 
ATOM   2    C CA   . ASP A 1 3   ? 2.07200   -51.80000 4.91600   1.000 48.98000  ? 3   ASP A CA   1 
ATOM   3    C C    . ASP A 1 3   ? 3.52100   -51.88200 4.43700   1.000 54.15000  ? 3   ASP A C    1 
ATOM   4    O O    . ASP A 1 3   ? 4.20000   -52.88100 4.66500   1.000 48.84000  ? 3   ASP A O    1 
ATOM   5    C CB   . ASP A 1 3   ? 1.75500   -52.91800 5.91200   1.000 30.00000  ? 3   ASP A CB   1 
ATOM   6    H HA   . ASP A 1 3   ? 1.91600   -50.96600 5.38600   1.000 48.98000  ? 3   ASP A HA   1 
ATOM   7    N N    . ALA A 1 4   ? 3.97100   -50.84200 3.73100   1.000 53.25000  ? 4   ALA A N    1 
ATOM   8    C CA   . ALA A 1 4   ? 5.28800   -50.86200 3.10000   1.000 39.71000  ? 4   ALA A CA   1 
ATOM   9    C C    . ALA A 1 4   ? 6.37200   -51.16900 4.12900   1.000 40.20000  ? 4   ALA A C    1 
ATOM   10   O O    . ALA A 1 4   ? 6.37700   -50.60000 5.22400   1.000 32.04000  ? 4   ALA A O    1 
ATOM   11   C CB   . ALA A 1 4   ? 5.56300   -49.50900 2.41800   1.000 36.86000  ? 4   ALA A CB   1 
ATOM   12   H H    . ALA A 1 4   ? 3.53200   -50.11400 3.60200   1.000 63.92000  ? 4   ALA A H    1 
ATOM   13   H HA   . ALA A 1 4   ? 5.31000   -51.55300 2.42100   1.000 47.67000  ? 4   ALA A HA   1 
ATOM   14   H HB1  . ALA A 1 4   ? 6.50700   -49.44800 2.20500   1.000 44.26000  ? 4   ALA A HB1  1 
ATOM   15   H HB2  . ALA A 1 4   ? 5.03600   -49.45200 1.60600   1.000 44.26000  ? 4   ALA A HB2  1 
ATOM   16   H HB3  . ALA A 1 4   ? 5.31300   -48.79300 3.02400   1.000 44.26000  ? 4   ALA A HB3  1 
ATOM   17   N N    . LYS A 1 5   ? 7.28800   -52.08300 3.76500   1.000 32.59000  ? 5   LYS A N    1 
ATOM   18   C CA   . LYS A 1 5   ? 8.44100   -52.37200 4.60100   1.000 42.99000  ? 5   LYS A CA   1 
ATOM   19   C C    . LYS A 1 5   ? 9.26100   -51.10000 4.80600   1.000 29.79000  ? 5   LYS A C    1 
ATOM   20   O O    . LYS A 1 5   ? 9.52700   -50.35100 3.86600   1.000 32.61000  ? 5   LYS A O    1 
ATOM   21   C CB   . LYS A 1 5   ? 9.31900   -53.46500 3.97000   1.000 39.29000  ? 5   LYS A CB   1 
ATOM   22   H H    . LYS A 1 5   ? 7.25600   -52.54300 3.03900   1.000 39.13000  ? 5   LYS A H    1 
ATOM   23   H HA   . LYS A 1 5   ? 8.13400   -52.70000 5.46100   1.000 51.61000  ? 5   LYS A HA   1 
ATOM   24   N N    . VAL A 1 6   ? 9.62600   -50.86100 6.05300   1.000 26.55000  ? 6   VAL A N    1 
ATOM   25   C CA   . VAL A 1 6   ? 10.58300  -49.82500 6.42900   1.000 25.04000  ? 6   VAL A CA   1 
ATOM   26   C C    . VAL A 1 6   ? 11.97900  -50.45600 6.43400   1.000 36.26000  ? 6   VAL A C    1 
ATOM   27   O O    . VAL A 1 6   ? 12.27200  -51.34300 7.24500   1.000 42.64000  ? 6   VAL A O    1 
ATOM   28   C CB   . VAL A 1 6   ? 10.22500  -49.25800 7.79300   1.000 29.72000  ? 6   VAL A CB   1 
ATOM   29   C CG1  . VAL A 1 6   ? 11.21900  -48.16200 8.21000   1.000 33.38000  ? 6   VAL A CG1  1 
ATOM   30   C CG2  . VAL A 1 6   ? 8.77300   -48.72300 7.83200   1.000 35.48000  ? 6   VAL A CG2  1 
ATOM   31   H H    . VAL A 1 6   ? 9.32500   -51.30000 6.72800   1.000 31.88000  ? 6   VAL A H    1 
ATOM   32   H HA   . VAL A 1 6   ? 10.58200  -49.10900 5.77400   1.000 30.06000  ? 6   VAL A HA   1 
ATOM   33   H HB   . VAL A 1 6   ? 10.28300  -49.98200 8.43700   1.000 35.68000  ? 6   VAL A HB   1 
ATOM   34   H HG11 . VAL A 1 6   ? 10.91400  -47.75700 9.03700   1.000 40.08000  ? 6   VAL A HG11 1 
ATOM   35   H HG12 . VAL A 1 6   ? 12.09300  -48.56100 8.33800   1.000 40.08000  ? 6   VAL A HG12 1 
ATOM   36   H HG13 . VAL A 1 6   ? 11.26000  -47.49100 7.51000   1.000 40.08000  ? 6   VAL A HG13 1 
ATOM   37   H HG21 . VAL A 1 6   ? 8.69200   -48.08000 8.55400   1.000 42.59000  ? 6   VAL A HG21 1 
ATOM   38   H HG22 . VAL A 1 6   ? 8.57100   -48.29600 6.98500   1.000 42.59000  ? 6   VAL A HG22 1 
ATOM   39   H HG23 . VAL A 1 6   ? 8.16600   -49.46500 7.98100   1.000 42.59000  ? 6   VAL A HG23 1 
ATOM   40   N N    . GLU A 1 7   ? 12.82400  -50.04700 5.49400   1.000 27.26000  ? 7   GLU A N    1 
ATOM   41   C CA   . GLU A 1 7   ? 14.18300  -50.58100 5.38100   1.000 23.93000  ? 7   GLU A CA   1 
ATOM   42   C C    . GLU A 1 7   ? 15.11400  -49.69100 6.19400   1.000 35.48000  ? 7   GLU A C    1 
ATOM   43   O O    . GLU A 1 7   ? 15.18000  -48.49200 5.92700   1.000 30.81000  ? 7   GLU A O    1 
ATOM   44   C CB   . GLU A 1 7   ? 14.66400  -50.62300 3.93700   1.000 28.37000  ? 7   GLU A CB   1 
ATOM   45   C CG   . GLU A 1 7   ? 14.03100  -51.62000 3.04300   1.000 43.36000  ? 7   GLU A CG   1 
ATOM   46   C CD   . GLU A 1 7   ? 14.83900  -51.78800 1.75800   1.000 56.25000  ? 7   GLU A CD   1 
ATOM   47   O OE1  . GLU A 1 7   ? 15.88000  -51.08700 1.60100   1.000 50.71000  ? 7   GLU A OE1  1 
ATOM   48   O OE2  . GLU A 1 7   ? 14.43000  -52.61000 0.91200   1.000 64.08000  ? 7   GLU A OE2  1 
ATOM   49   H H    . GLU A 1 7   ? 12.63500  -49.45400 4.90000   1.000 32.73000  ? 7   GLU A H    1 
ATOM   50   H HA   . GLU A 1 7   ? 14.18800  -51.48800 5.72600   1.000 28.74000  ? 7   GLU A HA   1 
ATOM   51   H HB2  . GLU A 1 7   ? 14.50600  -49.75100 3.54400   1.000 34.07000  ? 7   GLU A HB2  1 
ATOM   52   H HB3  . GLU A 1 7   ? 15.61500  -50.81600 3.94500   1.000 34.07000  ? 7   GLU A HB3  1 
ATOM   53   H HG2  . GLU A 1 7   ? 13.98800  -52.47800 3.49400   1.000 52.05000  ? 7   GLU A HG2  1 
ATOM   54   H HG3  . GLU A 1 7   ? 13.13800  -51.32300 2.80900   1.000 52.05000  ? 7   GLU A HG3  1 
ATOM   55   N N    . THR A 1 8   ? 15.86200  -50.25400 7.14700   1.000 28.90000  ? 8   THR A N    1 
ATOM   56   C CA   . THR A 1 8   ? 16.81900  -49.48300 7.93700   1.000 25.88000  ? 8   THR A CA   1 
ATOM   57   C C    . THR A 1 8   ? 18.23300  -49.68300 7.40900   1.000 34.04000  ? 8   THR A C    1 
ATOM   58   O O    . THR A 1 8   ? 18.63100  -50.78900 7.03300   1.000 29.86000  ? 8   THR A O    1 
ATOM   59   C CB   . THR A 1 8   ? 16.71700  -49.85500 9.42300   1.000 32.90000  ? 8   THR A CB   1 
ATOM   60   O OG1  . THR A 1 8   ? 15.39900  -49.53600 9.86800   1.000 36.60000  ? 8   THR A OG1  1 
ATOM   61   C CG2  . THR A 1 8   ? 17.71200  -49.09000 10.26400  1.000 39.23000  ? 8   THR A CG2  1 
ATOM   62   H H    . THR A 1 8   ? 15.83100  -51.08800 7.35300   1.000 34.70000  ? 8   THR A H    1 
ATOM   63   H HA   . THR A 1 8   ? 16.62200  -48.53700 7.85900   1.000 31.07000  ? 8   THR A HA   1 
ATOM   64   H HB   . THR A 1 8   ? 16.90800  -50.80000 9.53300   1.000 39.50000  ? 8   THR A HB   1 
ATOM   65   H HG1  . THR A 1 8   ? 15.34800  -49.62300 10.70200  1.000 43.94000  ? 8   THR A HG1  1 
ATOM   66   H HG21 . THR A 1 8   ? 17.42500  -49.08000 11.19100  1.000 47.10000  ? 8   THR A HG21 1 
ATOM   67   H HG22 . THR A 1 8   ? 18.58500  -49.51000 10.20900  1.000 47.10000  ? 8   THR A HG22 1 
ATOM   68   H HG23 . THR A 1 8   ? 17.78200  -48.17600 9.94600   1.000 47.10000  ? 8   THR A HG23 1 
ATOM   69   N N    . HIS A 1 9   ? 18.96200  -48.57700 7.31700   1.000 25.91000  ? 9   HIS A N    1 
ATOM   70   C CA   . HIS A 1 9   ? 20.30600  -48.55500 6.77300   1.000 25.13000  ? 9   HIS A CA   1 
ATOM   71   C C    . HIS A 1 9   ? 21.18300  -47.76000 7.72800   1.000 23.87000  ? 9   HIS A C    1 
ATOM   72   O O    . HIS A 1 9   ? 20.71600  -46.95600 8.55300   1.000 26.79000  ? 9   HIS A O    1 
ATOM   73   C CB   . HIS A 1 9   ? 20.37500  -47.91600 5.38200   1.000 25.46000  ? 9   HIS A CB   1 
ATOM   74   C CG   . HIS A 1 9   ? 19.50900  -48.58200 4.37600   1.000 26.43000  ? 9   HIS A CG   1 
ATOM   75   N ND1  . HIS A 1 9   ? 19.98900  -49.51300 3.48500   1.000 33.19000  ? 9   HIS A ND1  1 
ATOM   76   C CD2  . HIS A 1 9   ? 18.18800  -48.44300 4.11100   1.000 32.09000  ? 9   HIS A CD2  1 
ATOM   77   C CE1  . HIS A 1 9   ? 18.99200  -49.91900 2.71000   1.000 35.68000  ? 9   HIS A CE1  1 
ATOM   78   N NE2  . HIS A 1 9   ? 17.89000  -49.29100 3.07400   1.000 42.82000  ? 9   HIS A NE2  1 
ATOM   79   H H    . HIS A 1 9   ? 18.68800  -47.80300 7.57200   1.000 31.12000  ? 9   HIS A H    1 
ATOM   80   H HA   . HIS A 1 9   ? 20.63300  -49.46500 6.69000   1.000 30.18000  ? 9   HIS A HA   1 
ATOM   81   H HB2  . HIS A 1 9   ? 20.09300  -46.99000 5.45000   1.000 30.57000  ? 9   HIS A HB2  1 
ATOM   82   H HB3  . HIS A 1 9   ? 21.29000  -47.96200 5.06200   1.000 30.57000  ? 9   HIS A HB3  1 
ATOM   83   H HD2  . HIS A 1 9   ? 17.59300  -47.87800 4.55000   1.000 38.52000  ? 9   HIS A HD2  1 
ATOM   84   H HE1  . HIS A 1 9   ? 19.05800  -50.54400 2.02400   1.000 42.84000  ? 9   HIS A HE1  1 
ATOM   85   H HE2  . HIS A 1 9   ? 17.11400  -49.39600 2.71900   1.000 51.40000  ? 9   HIS A HE2  1 
ATOM   86   N N    . GLU A 1 10  ? 22.48700  -48.01900 7.63800   1.000 33.40000  ? 10  GLU A N    1 
ATOM   87   C CA   . GLU A 1 10  ? 23.47300  -47.36900 8.49400   1.000 34.50000  ? 10  GLU A CA   1 
ATOM   88   C C    . GLU A 1 10  ? 24.22300  -46.33200 7.68400   1.000 23.56000  ? 10  GLU A C    1 
ATOM   89   O O    . GLU A 1 10  ? 24.58200  -46.57800 6.52000   1.000 27.72000  ? 10  GLU A O    1 
ATOM   90   C CB   . GLU A 1 10  ? 24.45000  -48.40400 9.08800   1.000 34.33000  ? 10  GLU A CB   1 
ATOM   91   H H    . GLU A 1 10  ? 22.82800  -48.57600 7.07900   1.000 40.10000  ? 10  GLU A H    1 
ATOM   92   H HA   . GLU A 1 10  ? 23.02900  -46.91900 9.22900   1.000 41.42000  ? 10  GLU A HA   1 
ATOM   93   N N    . PHE A 1 11  ? 24.38600  -45.14700 8.27700   1.000 31.45000  ? 11  PHE A N    1 
ATOM   94   C CA   . PHE A 1 11  ? 25.22700  -44.13100 7.68000   1.000 26.07000  ? 11  PHE A CA   1 
ATOM   95   C C    . PHE A 1 11  ? 26.69600  -44.56100 7.77700   1.000 25.49000  ? 11  PHE A C    1 
ATOM   96   O O    . PHE A 1 11  ? 27.08000  -45.15400 8.78200   1.000 31.83000  ? 11  PHE A O    1 
ATOM   97   C CB   . PHE A 1 11  ? 25.10900  -42.79900 8.44400   1.000 24.04000  ? 11  PHE A CB   1 
ATOM   98   C CG   . PHE A 1 11  ? 23.87100  -41.95000 8.08900   1.000 21.04000  ? 11  PHE A CG   1 
ATOM   99   C CD1  . PHE A 1 11  ? 23.81300  -41.27200 6.91400   1.000 29.83000  ? 11  PHE A CD1  1 
ATOM   100  C CD2  . PHE A 1 11  ? 22.87400  -41.89300 8.98400   1.000 28.96000  ? 11  PHE A CD2  1 
ATOM   101  C CE1  . PHE A 1 11  ? 22.69400  -40.50600 6.61500   1.000 26.95000  ? 11  PHE A CE1  1 
ATOM   102  C CE2  . PHE A 1 11  ? 21.72800  -41.11600 8.68000   1.000 28.20000  ? 11  PHE A CE2  1 
ATOM   103  C CZ   . PHE A 1 11  ? 21.70900  -40.45600 7.51000   1.000 23.27000  ? 11  PHE A CZ   1 
ATOM   104  H H    . PHE A 1 11  ? 24.02000  -44.91500 9.01900   1.000 37.76000  ? 11  PHE A H    1 
ATOM   105  H HA   . PHE A 1 11  ? 24.95300  -44.00700 6.75700   1.000 31.31000  ? 11  PHE A HA   1 
ATOM   106  H HB2  . PHE A 1 11  ? 25.06500  -42.99300 9.39300   1.000 28.87000  ? 11  PHE A HB2  1 
ATOM   107  H HB3  . PHE A 1 11  ? 25.89400  -42.26300 8.25000   1.000 28.87000  ? 11  PHE A HB3  1 
ATOM   108  H HD1  . PHE A 1 11  ? 24.51900  -41.32000 6.31200   1.000 35.81000  ? 11  PHE A HD1  1 
ATOM   109  H HD2  . PHE A 1 11  ? 22.93300  -42.35500 9.78900   1.000 34.77000  ? 11  PHE A HD2  1 
ATOM   110  H HE1  . PHE A 1 11  ? 22.63500  -40.04100 5.81200   1.000 32.36000  ? 11  PHE A HE1  1 
ATOM   111  H HE2  . PHE A 1 11  ? 21.01300  -41.06500 9.27100   1.000 33.86000  ? 11  PHE A HE2  1 
ATOM   112  H HZ   . PHE A 1 11  ? 20.96500  -39.93400 7.31400   1.000 27.94000  ? 11  PHE A HZ   1 
ATOM   113  N N    . THR A 1 12  ? 27.46900  -44.24900 6.75200   1.000 30.46000  ? 12  THR A N    1 
ATOM   114  C CA   . THR A 1 12  ? 28.92400  -44.35300 6.90500   1.000 35.61000  ? 12  THR A CA   1 
ATOM   115  C C    . THR A 1 12  ? 29.35300  -43.53900 8.12200   1.000 50.36000  ? 12  THR A C    1 
ATOM   116  O O    . THR A 1 12  ? 28.72800  -42.52700 8.48400   1.000 41.98000  ? 12  THR A O    1 
ATOM   117  C CB   . THR A 1 12  ? 29.70500  -43.82400 5.71300   1.000 45.26000  ? 12  THR A CB   1 
ATOM   118  O OG1  . THR A 1 12  ? 29.75900  -42.38900 5.80000   1.000 63.19000  ? 12  THR A OG1  1 
ATOM   119  C CG2  . THR A 1 12  ? 29.10600  -44.22100 4.42100   1.000 42.98000  ? 12  THR A CG2  1 
ATOM   120  H H    . THR A 1 12  ? 27.19400  -43.98400 5.98200   1.000 36.57000  ? 12  THR A H    1 
ATOM   121  H HA   . THR A 1 12  ? 29.13800  -45.29500 6.99300   1.000 42.75000  ? 12  THR A HA   1 
ATOM   122  H HB   . THR A 1 12  ? 30.59800  -44.20200 5.73000   1.000 54.33000  ? 12  THR A HB   1 
ATOM   123  H HG1  . THR A 1 12  ? 30.19300  -42.07800 5.15100   1.000 75.84000  ? 12  THR A HG1  1 
ATOM   124  H HG21 . THR A 1 12  ? 29.64400  -43.88200 3.68800   1.000 51.60000  ? 12  THR A HG21 1 
ATOM   125  H HG22 . THR A 1 12  ? 29.06300  -45.18800 4.35900   1.000 51.60000  ? 12  THR A HG22 1 
ATOM   126  H HG23 . THR A 1 12  ? 28.20900  -43.86000 4.34600   1.000 51.60000  ? 12  THR A HG23 1 
ATOM   127  N N    . ALA A 1 13  ? 30.44900  -43.96200 8.75200   1.000 39.19000  ? 13  ALA A N    1 
ATOM   128  C CA   . ALA A 1 13  ? 30.86000  -43.30500 9.99200   1.000 32.41000  ? 13  ALA A CA   1 
ATOM   129  C C    . ALA A 1 13  ? 31.13900  -41.80200 9.78300   1.000 28.48000  ? 13  ALA A C    1 
ATOM   130  O O    . ALA A 1 13  ? 30.77900  -40.98800 10.63600  1.000 33.30000  ? 13  ALA A O    1 
ATOM   131  C CB   . ALA A 1 13  ? 32.10600  -43.98900 10.56700  1.000 39.63000  ? 13  ALA A CB   1 
ATOM   132  H H    . ALA A 1 13  ? 30.95600  -44.60600 8.49200   1.000 47.05000  ? 13  ALA A H    1 
ATOM   133  H HA   . ALA A 1 13  ? 30.13500  -43.39100 10.63000  1.000 38.92000  ? 13  ALA A HA   1 
ATOM   134  H HB1  . ALA A 1 13  ? 32.50700  -43.40800 11.23100  1.000 47.57000  ? 13  ALA A HB1  1 
ATOM   135  H HB2  . ALA A 1 13  ? 31.84400  -44.82800 10.97600  1.000 47.57000  ? 13  ALA A HB2  1 
ATOM   136  H HB3  . ALA A 1 13  ? 32.73500  -44.15400 9.84800   1.000 47.57000  ? 13  ALA A HB3  1 
ATOM   137  N N    . GLU A 1 14  ? 31.76500  -41.44000 8.66300   1.000 30.92000  ? 14  GLU A N    1 
ATOM   138  C CA   . GLU A 1 14  ? 32.12400  -40.04000 8.41600   1.000 27.75000  ? 14  GLU A CA   1 
ATOM   139  C C    . GLU A 1 14  ? 30.88100  -39.14900 8.35200   1.000 39.93000  ? 14  GLU A C    1 
ATOM   140  O O    . GLU A 1 14  ? 30.90600  -37.99400 8.80200   1.000 33.87000  ? 14  GLU A O    1 
ATOM   141  C CB   . GLU A 1 14  ? 32.91300  -39.93100 7.13000   1.000 39.80000  ? 14  GLU A CB   1 
ATOM   142  C CG   . GLU A 1 14  ? 34.39200  -40.32400 7.32900   1.000 48.23000  ? 14  GLU A CG   1 
ATOM   143  C CD   . GLU A 1 14  ? 34.65200  -41.79900 7.06400   1.000 72.06000  ? 14  GLU A CD   1 
ATOM   144  O OE1  . GLU A 1 14  ? 33.69500  -42.56500 6.74300   1.000 59.29000  ? 14  GLU A OE1  1 
ATOM   145  O OE2  . GLU A 1 14  ? 35.82600  -42.20100 7.20300   1.000 80.47000  ? 14  GLU A OE2  1 
ATOM   146  H H    . GLU A 1 14  ? 31.99300  -41.97900 8.03300   1.000 37.12000  ? 14  GLU A H    1 
ATOM   147  H HA   . GLU A 1 14  ? 32.68100  -39.72700 9.14600   1.000 33.32000  ? 14  GLU A HA   1 
ATOM   148  H HB2  . GLU A 1 14  ? 32.52700  -40.52500 6.46700   1.000 47.77000  ? 14  GLU A HB2  1 
ATOM   149  H HB3  . GLU A 1 14  ? 32.88200  -39.01500 6.81300   1.000 47.77000  ? 14  GLU A HB3  1 
ATOM   150  H HG2  . GLU A 1 14  ? 34.94100  -39.80900 6.71700   1.000 57.90000  ? 14  GLU A HG2  1 
ATOM   151  H HG3  . GLU A 1 14  ? 34.64900  -40.13500 8.24400   1.000 57.90000  ? 14  GLU A HG3  1 
ATOM   152  N N    . ILE A 1 15  ? 29.79300  -39.66400 7.77300   1.000 31.36000  ? 15  ILE A N    1 
ATOM   153  C CA   . ILE A 1 15  ? 28.58800  -38.85400 7.61200   1.000 29.81000  ? 15  ILE A CA   1 
ATOM   154  C C    . ILE A 1 15  ? 27.87400  -38.70700 8.95200   1.000 27.27000  ? 15  ILE A C    1 
ATOM   155  O O    . ILE A 1 15  ? 27.40600  -37.61400 9.33000   1.000 28.56000  ? 15  ILE A O    1 
ATOM   156  C CB   . ILE A 1 15  ? 27.67800  -39.48300 6.55400   1.000 24.22000  ? 15  ILE A CB   1 
ATOM   157  C CG1  . ILE A 1 15  ? 28.23300  -39.26700 5.17900   1.000 28.91000  ? 15  ILE A CG1  1 
ATOM   158  C CG2  . ILE A 1 15  ? 26.26600  -38.87600 6.67800   1.000 31.04000  ? 15  ILE A CG2  1 
ATOM   159  C CD1  . ILE A 1 15  ? 27.84900  -40.36000 4.14400   1.000 50.09000  ? 15  ILE A CD1  1 
ATOM   160  H H    . ILE A 1 15  ? 29.73000  -40.46600 7.47100   1.000 37.65000  ? 15  ILE A H    1 
ATOM   161  H HA   . ILE A 1 15  ? 28.83800  -37.96800 7.30700   1.000 35.79000  ? 15  ILE A HA   1 
ATOM   162  H HB   . ILE A 1 15  ? 27.63100  -40.44000 6.70300   1.000 29.09000  ? 15  ILE A HB   1 
ATOM   163  H HG12 . ILE A 1 15  ? 27.90400  -38.41900 4.84400   1.000 34.71000  ? 15  ILE A HG12 1 
ATOM   164  H HG13 . ILE A 1 15  ? 29.20100  -39.24800 5.23700   1.000 34.71000  ? 15  ILE A HG13 1 
ATOM   165  H HG21 . ILE A 1 15  ? 25.69400  -39.26300 5.99700   1.000 37.26000  ? 15  ILE A HG21 1 
ATOM   166  H HG22 . ILE A 1 15  ? 25.91200  -39.07600 7.55900   1.000 37.26000  ? 15  ILE A HG22 1 
ATOM   167  H HG23 . ILE A 1 15  ? 26.32300  -37.91500 6.55600   1.000 37.26000  ? 15  ILE A HG23 1 
ATOM   168  H HD11 . ILE A 1 15  ? 28.24800  -40.13800 3.28800   1.000 60.13000  ? 15  ILE A HD11 1 
ATOM   169  H HD12 . ILE A 1 15  ? 28.18100  -41.21800 4.45100   1.000 60.13000  ? 15  ILE A HD12 1 
ATOM   170  H HD13 . ILE A 1 15  ? 26.88300  -40.39000 4.06100   1.000 60.13000  ? 15  ILE A HD13 1 
ATOM   171  N N    . SER A 1 16  ? 27.81400  -39.77400 9.73200   1.000 27.46000  ? 16  SER A N    1 
ATOM   172  C CA   . SER A 1 16  ? 27.29500  -39.67900 11.07600  1.000 25.62000  ? 16  SER A CA   1 
ATOM   173  C C    . SER A 1 16  ? 28.09100  -38.64800 11.87400  1.000 31.24000  ? 16  SER A C    1 
ATOM   174  O O    . SER A 1 16  ? 27.52100  -37.86800 12.64600  1.000 28.72000  ? 16  SER A O    1 
ATOM   175  C CB   . SER A 1 16  ? 27.31000  -41.06400 11.74600  1.000 42.84000  ? 16  SER A CB   1 
ATOM   176  O OG   . SER A 1 16  ? 27.00200  -40.95000 13.11700  1.000 56.91000  ? 16  SER A OG   1 
ATOM   177  H H    . SER A 1 16  ? 28.06800  -40.56300 9.50400   1.000 32.97000  ? 16  SER A H    1 
ATOM   178  H HA   . SER A 1 16  ? 26.37000  -39.38900 11.05600  1.000 30.76000  ? 16  SER A HA   1 
ATOM   179  H HB2  . SER A 1 16  ? 26.64900  -41.63100 11.31800  1.000 51.43000  ? 16  SER A HB2  1 
ATOM   180  H HB3  . SER A 1 16  ? 28.19300  -41.45400 11.65000  1.000 51.43000  ? 16  SER A HB3  1 
ATOM   181  H HG   . SER A 1 16  ? 26.31300  -40.48100 13.21800  1.000 68.32000  ? 16  SER A HG   1 
ATOM   182  N N    . GLN A 1 17  ? 29.41000  -38.64300 11.68600  1.000 30.13000  ? 17  GLN A N    1 
ATOM   183  C CA   . GLN A 1 17  ? 30.25700  -37.70200 12.40000  1.000 32.84000  ? 17  GLN A CA   1 
ATOM   184  C C    . GLN A 1 17  ? 29.92000  -36.26500 12.01800  1.000 25.16000  ? 17  GLN A C    1 
ATOM   185  O O    . GLN A 1 17  ? 29.82800  -35.37900 12.89100  1.000 26.82000  ? 17  GLN A O    1 
ATOM   186  C CB   . GLN A 1 17  ? 31.71800  -37.98300 12.06100  1.000 37.62000  ? 17  GLN A CB   1 
ATOM   187  C CG   . GLN A 1 17  ? 32.70300  -37.34200 12.97600  1.000 51.37000  ? 17  GLN A CG   1 
ATOM   188  C CD   . GLN A 1 17  ? 34.11100  -37.61500 12.51000  1.000 60.27000  ? 17  GLN A CD   1 
ATOM   189  O OE1  . GLN A 1 17  ? 34.35800  -38.61500 11.79700  1.000 44.09000  ? 17  GLN A OE1  1 
ATOM   190  N NE2  . GLN A 1 17  ? 35.05200  -36.73600 12.89700  1.000 55.05000  ? 17  GLN A NE2  1 
ATOM   191  H H    . GLN A 1 17  ? 29.83300  -39.17000 11.15400  1.000 36.17000  ? 17  GLN A H    1 
ATOM   192  H HA   . GLN A 1 17  ? 30.12000  -37.81200 13.35400  1.000 39.43000  ? 17  GLN A HA   1 
ATOM   193  H HB2  . GLN A 1 17  ? 31.86400  -38.94100 12.09900  1.000 45.16000  ? 17  GLN A HB2  1 
ATOM   194  H HB3  . GLN A 1 17  ? 31.89500  -37.65500 11.16600  1.000 45.16000  ? 17  GLN A HB3  1 
ATOM   195  H HG2  . GLN A 1 17  ? 32.56100  -36.38300 12.98600  1.000 61.66000  ? 17  GLN A HG2  1 
ATOM   196  H HG3  . GLN A 1 17  ? 32.59800  -37.70300 13.87000  1.000 61.66000  ? 17  GLN A HG3  1 
ATOM   197  H HE21 . GLN A 1 17  ? 34.83600  -36.06200 13.38500  1.000 66.08000  ? 17  GLN A HE21 1 
ATOM   198  H HE22 . GLN A 1 17  ? 35.87000  -36.84800 12.65700  1.000 66.08000  ? 17  GLN A HE22 1 
ATOM   199  N N    . LEU A 1 18  ? 29.76300  -36.03400 10.72100  1.000 25.81000  ? 18  LEU A N    1 
ATOM   200  C CA   . LEU A 1 18  ? 29.42900  -34.68300 10.23900  1.000 22.78000  ? 18  LEU A CA   1 
ATOM   201  C C    . LEU A 1 18  ? 28.06000  -34.25600 10.76200  1.000 25.62000  ? 18  LEU A C    1 
ATOM   202  O O    . LEU A 1 18  ? 27.86300  -33.09600 11.16100  1.000 23.83000  ? 18  LEU A O    1 
ATOM   203  C CB   . LEU A 1 18  ? 29.47500  -34.66200 8.71700   1.000 25.61000  ? 18  LEU A CB   1 
ATOM   204  C CG   . LEU A 1 18  ? 28.96300  -33.38100 8.07400   1.000 27.24000  ? 18  LEU A CG   1 
ATOM   205  C CD1  . LEU A 1 18  ? 29.80200  -32.22600 8.50600   1.000 29.89000  ? 18  LEU A CD1  1 
ATOM   206  C CD2  . LEU A 1 18  ? 28.89600  -33.55200 6.54700   1.000 35.73000  ? 18  LEU A CD2  1 
ATOM   207  H H    . LEU A 1 18  ? 29.84100  -36.62600 10.10200  1.000 30.99000  ? 18  LEU A H    1 
ATOM   208  H HA   . LEU A 1 18  ? 30.08300  -34.04300 10.55900  1.000 27.35000  ? 18  LEU A HA   1 
ATOM   209  H HB2  . LEU A 1 18  ? 30.39600  -34.78100 8.43700   1.000 30.75000  ? 18  LEU A HB2  1 
ATOM   210  H HB3  . LEU A 1 18  ? 28.93000  -35.39200 8.38400   1.000 30.75000  ? 18  LEU A HB3  1 
ATOM   211  H HG   . LEU A 1 18  ? 28.05900  -33.18400 8.36600   1.000 32.70000  ? 18  LEU A HG   1 
ATOM   212  H HD11 . LEU A 1 18  ? 29.75800  -31.53300 7.82800   1.000 35.89000  ? 18  LEU A HD11 1 
ATOM   213  H HD12 . LEU A 1 18  ? 29.46200  -31.88600 9.34800   1.000 35.89000  ? 18  LEU A HD12 1 
ATOM   214  H HD13 . LEU A 1 18  ? 30.71800  -32.52400 8.61400   1.000 35.89000  ? 18  LEU A HD13 1 
ATOM   215  H HD21 . LEU A 1 18  ? 28.19500  -32.98100 6.19500   1.000 42.90000  ? 18  LEU A HD21 1 
ATOM   216  H HD22 . LEU A 1 18  ? 29.75100  -33.30100 6.16300   1.000 42.90000  ? 18  LEU A HD22 1 
ATOM   217  H HD23 . LEU A 1 18  ? 28.70100  -34.48000 6.34200   1.000 42.90000  ? 18  LEU A HD23 1 
ATOM   218  N N    . MET A 1 19  ? 27.07700  -35.15200 10.73400  1.000 23.71000  ? 19  MET A N    1 
ATOM   219  C CA   . MET A 1 19  ? 25.75200  -34.78600 11.22100  1.000 23.23000  ? 19  MET A CA   1 
ATOM   220  C C    . MET A 1 19  ? 25.80500  -34.35300 12.67300  1.000 26.21000  ? 19  MET A C    1 
ATOM   221  O O    . MET A 1 19  ? 25.13500  -33.39600 13.07100  1.000 25.62000  ? 19  MET A O    1 
ATOM   222  C CB   . MET A 1 19  ? 24.78400  -35.96100 11.05400  1.000 25.06000  ? 19  MET A CB   1 
ATOM   223  C CG   . MET A 1 19  ? 24.39200  -36.07400 9.63300   1.000 25.08000  ? 19  MET A CG   1 
ATOM   224  S SD   . MET A 1 19  ? 23.13900  -37.38000 9.37400   1.000 33.24000  ? 19  MET A SD   1 
ATOM   225  C CE   . MET A 1 19  ? 23.90400  -38.78300 10.00600  1.000 34.92000  ? 19  MET A CE   1 
ATOM   226  H H    . MET A 1 19  ? 27.14800  -35.95900 10.44500  1.000 28.47000  ? 19  MET A H    1 
ATOM   227  H HA   . MET A 1 19  ? 25.42200  -34.04900 10.68300  1.000 27.90000  ? 19  MET A HA   1 
ATOM   228  H HB2  . MET A 1 19  ? 25.21600  -36.78400 11.32700  1.000 30.09000  ? 19  MET A HB2  1 
ATOM   229  H HB3  . MET A 1 19  ? 23.98800  -35.81000 11.58800  1.000 30.09000  ? 19  MET A HB3  1 
ATOM   230  H HG2  . MET A 1 19  ? 24.01700  -35.23000 9.33600   1.000 30.12000  ? 19  MET A HG2  1 
ATOM   231  H HG3  . MET A 1 19  ? 25.17400  -36.29400 9.10200   1.000 30.12000  ? 19  MET A HG3  1 
ATOM   232  H HE1  . MET A 1 19  ? 23.29400  -39.53400 9.93500   1.000 41.92000  ? 19  MET A HE1  1 
ATOM   233  H HE2  . MET A 1 19  ? 24.70900  -38.96100 9.49500   1.000 41.92000  ? 19  MET A HE2  1 
ATOM   234  H HE3  . MET A 1 19  ? 24.13000  -38.62700 10.93600  1.000 41.92000  ? 19  MET A HE3  1 
ATOM   235  N N    . SER A 1 20  ? 26.54100  -35.10200 13.50000  1.000 24.83000  ? 20  SER A N    1 
ATOM   236  C CA   A SER A 1 20  ? 26.66000  -34.75300 14.90700  0.520 26.40000  ? 20  SER A CA   1 
ATOM   237  C CA   B SER A 1 20  ? 26.64600  -34.74800 14.90500  0.480 26.38000  ? 20  SER A CA   1 
ATOM   238  C C    . SER A 1 20  ? 27.29200  -33.37900 15.08800  1.000 24.26000  ? 20  SER A C    1 
ATOM   239  O O    . SER A 1 20  ? 26.81600  -32.56800 15.88100  1.000 27.19000  ? 20  SER A O    1 
ATOM   240  C CB   A SER A 1 20  ? 27.49600  -35.83200 15.60100  0.520 28.45000  ? 20  SER A CB   1 
ATOM   241  C CB   B SER A 1 20  ? 27.45500  -35.82400 15.63300  0.480 28.68000  ? 20  SER A CB   1 
ATOM   242  O OG   A SER A 1 20  ? 26.68900  -36.94800 15.92500  0.520 36.38000  ? 20  SER A OG   1 
ATOM   243  O OG   B SER A 1 20  ? 27.43500  -35.57600 17.02800  0.480 33.69000  ? 20  SER A OG   1 
ATOM   244  H H    A SER A 1 20  ? 26.97500  -35.80800 13.27000  0.520 29.82000  ? 20  SER A H    1 
ATOM   245  H H    B SER A 1 20  ? 26.97900  -35.80600 13.27200  0.480 29.82000  ? 20  SER A H    1 
ATOM   246  H HA   A SER A 1 20  ? 25.78000  -34.71900 15.31400  0.520 31.70000  ? 20  SER A HA   1 
ATOM   247  H HA   B SER A 1 20  ? 25.75800  -34.70800 15.29200  0.480 31.68000  ? 20  SER A HA   1 
ATOM   248  H HB2  A SER A 1 20  ? 28.20600  -36.11600 15.00400  0.520 34.16000  ? 20  SER A HB2  1 
ATOM   249  H HB2  B SER A 1 20  ? 27.06200  -36.69400 15.45700  0.480 34.44000  ? 20  SER A HB2  1 
ATOM   250  H HB3  A SER A 1 20  ? 27.87300  -35.46600 16.41600  0.520 34.16000  ? 20  SER A HB3  1 
ATOM   251  H HB3  B SER A 1 20  ? 28.37100  -35.80400 15.31700  0.480 34.44000  ? 20  SER A HB3  1 
ATOM   252  H HG   A SER A 1 20  ? 26.01800  -36.97400 15.42000  0.520 43.67000  ? 20  SER A HG   1 
ATOM   253  H HG   B SER A 1 20  ? 27.98600  -34.97100 17.22000  0.480 40.45000  ? 20  SER A HG   1 
ATOM   254  N N    . LEU A 1 21  ? 28.32600  -33.09000 14.32100  1.000 22.46000  ? 21  LEU A N    1 
ATOM   255  C CA   . LEU A 1 21  ? 28.95500  -31.76500 14.38200  1.000 25.43000  ? 21  LEU A CA   1 
ATOM   256  C C    . LEU A 1 21  ? 27.93700  -30.66300 14.03300  1.000 27.80000  ? 21  LEU A C    1 
ATOM   257  O O    . LEU A 1 21  ? 27.73000  -29.70000 14.79900  1.000 27.78000  ? 21  LEU A O    1 
ATOM   258  C CB   . LEU A 1 21  ? 30.12700  -31.70700 13.44000  1.000 28.18000  ? 21  LEU A CB   1 
ATOM   259  C CG   . LEU A 1 21  ? 31.45500  -32.31600 13.86000  1.000 45.20000  ? 21  LEU A CG   1 
ATOM   260  C CD1  . LEU A 1 21  ? 32.36900  -32.52900 12.65100  1.000 41.67000  ? 21  LEU A CD1  1 
ATOM   261  C CD2  . LEU A 1 21  ? 32.14300  -31.46400 14.90200  1.000 42.57000  ? 21  LEU A CD2  1 
ATOM   262  H H    . LEU A 1 21  ? 28.68700  -33.63100 13.75800  1.000 26.98000  ? 21  LEU A H    1 
ATOM   263  H HA   . LEU A 1 21  ? 29.28200  -31.61300 15.28200  1.000 30.53000  ? 21  LEU A HA   1 
ATOM   264  H HB2  . LEU A 1 21  ? 29.86400  -32.16300 12.62400  1.000 33.84000  ? 21  LEU A HB2  1 
ATOM   265  H HB3  . LEU A 1 21  ? 30.30300  -30.77100 13.25500  1.000 33.84000  ? 21  LEU A HB3  1 
ATOM   266  H HG   . LEU A 1 21  ? 31.27700  -33.18300 14.25700  1.000 54.26000  ? 21  LEU A HG   1 
ATOM   267  H HD11 . LEU A 1 21  ? 32.23400  -31.80300 12.02200  1.000 50.02000  ? 21  LEU A HD11 1 
ATOM   268  H HD12 . LEU A 1 21  ? 33.29200  -32.53900 12.95100  1.000 50.02000  ? 21  LEU A HD12 1 
ATOM   269  H HD13 . LEU A 1 21  ? 32.14800  -33.37500 12.23300  1.000 50.02000  ? 21  LEU A HD13 1 
ATOM   270  H HD21 . LEU A 1 21  ? 32.72200  -30.82600 14.45600  1.000 51.10000  ? 21  LEU A HD21 1 
ATOM   271  H HD22 . LEU A 1 21  ? 31.47100  -30.99400 15.42000  1.000 51.10000  ? 21  LEU A HD22 1 
ATOM   272  H HD23 . LEU A 1 21  ? 32.66800  -32.03700 15.48300  1.000 51.10000  ? 21  LEU A HD23 1 
ATOM   273  N N    . ILE A 1 22  ? 27.20700  -30.83900 12.92200  1.000 23.87000  ? 22  ILE A N    1 
ATOM   274  C CA   . ILE A 1 22  ? 26.31900  -29.76100 12.49500  1.000 20.53000  ? 22  ILE A CA   1 
ATOM   275  C C    . ILE A 1 22  ? 25.17000  -29.58400 13.45900  1.000 23.09000  ? 22  ILE A C    1 
ATOM   276  O O    . ILE A 1 22  ? 24.72200  -28.45400 13.70800  1.000 23.79000  ? 22  ILE A O    1 
ATOM   277  C CB   . ILE A 1 22  ? 25.83300  -30.01200 11.05500  1.000 18.06000  ? 22  ILE A CB   1 
ATOM   278  C CG1  . ILE A 1 22  ? 27.01100  -30.03300 10.14300  1.000 17.61000  ? 22  ILE A CG1  1 
ATOM   279  C CG2  . ILE A 1 22  ? 24.80400  -28.96900 10.64600  1.000 19.38000  ? 22  ILE A CG2  1 
ATOM   280  C CD1  . ILE A 1 22  ? 27.80800  -28.82700 10.01800  1.000 40.56000  ? 22  ILE A CD1  1 
ATOM   281  H H    . ILE A 1 22  ? 27.21100  -31.54000 12.42400  1.000 28.66000  ? 22  ILE A H    1 
ATOM   282  H HA   . ILE A 1 22  ? 26.82300  -28.93200 12.50100  1.000 24.65000  ? 22  ILE A HA   1 
ATOM   283  H HB   . ILE A 1 22  ? 25.39200  -30.87500 11.00200  1.000 21.70000  ? 22  ILE A HB   1 
ATOM   284  H HG12 . ILE A 1 22  ? 27.61000  -30.72900 10.45400  1.000 21.15000  ? 22  ILE A HG12 1 
ATOM   285  H HG13 . ILE A 1 22  ? 26.68900  -30.24500 9.25300   1.000 21.15000  ? 22  ILE A HG13 1 
ATOM   286  H HG21 . ILE A 1 22  ? 24.50200  -29.16100 9.74500   1.000 23.28000  ? 22  ILE A HG21 1 
ATOM   287  H HG22 . ILE A 1 22  ? 24.05600  -29.00700 11.26200  1.000 23.28000  ? 22  ILE A HG22 1 
ATOM   288  H HG23 . ILE A 1 22  ? 25.21500  -28.09100 10.67800  1.000 23.28000  ? 22  ILE A HG23 1 
ATOM   289  H HD11 . ILE A 1 22  ? 28.52300  -28.98500 9.38100   1.000 48.70000  ? 22  ILE A HD11 1 
ATOM   290  H HD12 . ILE A 1 22  ? 27.24200  -28.10400 9.70500   1.000 48.70000  ? 22  ILE A HD12 1 
ATOM   291  H HD13 . ILE A 1 22  ? 28.18100  -28.60300 10.88500  1.000 48.70000  ? 22  ILE A HD13 1 
ATOM   292  N N    . ILE A 1 23  ? 24.56000  -30.68300 13.92600  1.000 21.92000  ? 23  ILE A N    1 
ATOM   293  C CA   . ILE A 1 23  ? 23.35300  -30.52700 14.73600  1.000 22.36000  ? 23  ILE A CA   1 
ATOM   294  C C    . ILE A 1 23  ? 23.67300  -29.86300 16.08300  1.000 27.67000  ? 23  ILE A C    1 
ATOM   295  O O    . ILE A 1 23  ? 22.78200  -29.22900 16.67500  1.000 29.38000  ? 23  ILE A O    1 
ATOM   296  C CB   . ILE A 1 23  ? 22.59400  -31.87000 14.90400  1.000 25.17000  ? 23  ILE A CB   1 
ATOM   297  C CG1  . ILE A 1 23  ? 21.09000  -31.59500 15.16700  1.000 27.29000  ? 23  ILE A CG1  1 
ATOM   298  C CG2  . ILE A 1 23  ? 23.18400  -32.65100 16.02900  1.000 27.02000  ? 23  ILE A CG2  1 
ATOM   299  C CD1  . ILE A 1 23  ? 20.23100  -32.87000 15.14800  1.000 36.16000  ? 23  ILE A CD1  1 
ATOM   300  H H    . ILE A 1 23  ? 24.81700  -31.49200 13.79200  1.000 26.32000  ? 23  ILE A H    1 
ATOM   301  H HA   . ILE A 1 23  ? 22.74300  -29.94200 14.26100  1.000 26.85000  ? 23  ILE A HA   1 
ATOM   302  H HB   . ILE A 1 23  ? 22.67900  -32.38700 14.08800  1.000 30.22000  ? 23  ILE A HB   1 
ATOM   303  H HG12 . ILE A 1 23  ? 20.99400  -31.18200 16.03900  1.000 32.77000  ? 23  ILE A HG12 1 
ATOM   304  H HG13 . ILE A 1 23  ? 20.75500  -30.99800 14.47900  1.000 32.77000  ? 23  ILE A HG13 1 
ATOM   305  H HG21 . ILE A 1 23  ? 22.95000  -33.58600 15.92200  1.000 32.44000  ? 23  ILE A HG21 1 
ATOM   306  H HG22 . ILE A 1 23  ? 24.14900  -32.54700 16.01300  1.000 32.44000  ? 23  ILE A HG22 1 
ATOM   307  H HG23 . ILE A 1 23  ? 22.82900  -32.31500 16.86700  1.000 32.44000  ? 23  ILE A HG23 1 
ATOM   308  H HD11 . ILE A 1 23  ? 19.32400  -32.64300 15.41000  1.000 43.41000  ? 23  ILE A HD11 1 
ATOM   309  H HD12 . ILE A 1 23  ? 20.23300  -33.24000 14.25200  1.000 43.41000  ? 23  ILE A HD12 1 
ATOM   310  H HD13 . ILE A 1 23  ? 20.60400  -33.51100 15.77200  1.000 43.41000  ? 23  ILE A HD13 1 
ATOM   311  N N    . ASN A 1 24  ? 24.91600  -29.94500 16.52900  1.000 26.20000  ? 24  ASN A N    1 
ATOM   312  C CA   . ASN A 1 24  ? 25.31600  -29.40700 17.81700  1.000 35.87000  ? 24  ASN A CA   1 
ATOM   313  C C    . ASN A 1 24  ? 26.03700  -28.07500 17.72600  1.000 36.50000  ? 24  ASN A C    1 
ATOM   314  O O    . ASN A 1 24  ? 26.16100  -27.40200 18.76300  1.000 33.91000  ? 24  ASN A O    1 
ATOM   315  C CB   . ASN A 1 24  ? 26.20100  -30.43400 18.52700  1.000 28.78000  ? 24  ASN A CB   1 
ATOM   316  C CG   . ASN A 1 24  ? 25.40900  -31.60800 19.04400  1.000 32.03000  ? 24  ASN A CG   1 
ATOM   317  O OD1  . ASN A 1 24  ? 25.73500  -32.76300 18.77300  1.000 40.99000  ? 24  ASN A OD1  1 
ATOM   318  N ND2  . ASN A 1 24  ? 24.36600  -31.32800 19.75700  1.000 35.66000  ? 24  ASN A ND2  1 
ATOM   319  H H    . ASN A 1 24  ? 25.55900  -30.31500 16.09400  1.000 31.46000  ? 24  ASN A H    1 
ATOM   320  H HA   . ASN A 1 24  ? 24.52700  -29.25300 18.35900  1.000 43.07000  ? 24  ASN A HA   1 
ATOM   321  H HB2  . ASN A 1 24  ? 26.86400  -30.76800 17.90300  1.000 34.55000  ? 24  ASN A HB2  1 
ATOM   322  H HB3  . ASN A 1 24  ? 26.63900  -30.00900 19.28000  1.000 34.55000  ? 24  ASN A HB3  1 
ATOM   323  H HD21 . ASN A 1 24  ? 23.88000  -31.96100 20.07600  1.000 42.81000  ? 24  ASN A HD21 1 
ATOM   324  H HD22 . ASN A 1 24  ? 24.15900  -30.50800 19.91100  1.000 42.81000  ? 24  ASN A HD22 1 
ATOM   325  N N    . THR A 1 25  ? 26.43700  -27.63600 16.53200  1.000 26.07000  ? 25  THR A N    1 
ATOM   326  C CA   . THR A 1 25  ? 27.26200  -26.43100 16.41800  1.000 23.61000  ? 25  THR A CA   1 
ATOM   327  C C    . THR A 1 25  ? 26.46500  -25.18900 16.76600  1.000 27.98000  ? 25  THR A C    1 
ATOM   328  O O    . THR A 1 25  ? 25.27200  -25.07200 16.48500  1.000 25.70000  ? 25  THR A O    1 
ATOM   329  C CB   . THR A 1 25  ? 27.86900  -26.29800 15.04000  1.000 27.08000  ? 25  THR A CB   1 
ATOM   330  O OG1  . THR A 1 25  ? 28.77700  -25.17800 14.98900  1.000 28.80000  ? 25  THR A OG1  1 
ATOM   331  C CG2  . THR A 1 25  ? 26.80000  -26.08300 13.94500  1.000 24.43000  ? 25  THR A CG2  1 
ATOM   332  H H    . THR A 1 25  ? 26.24700  -28.01200 15.78300  1.000 31.31000  ? 25  THR A H    1 
ATOM   333  H HA   . THR A 1 25  ? 27.99700  -26.50300 17.04700  1.000 28.35000  ? 25  THR A HA   1 
ATOM   334  H HB   . THR A 1 25  ? 28.33900  -27.12700 14.85800  1.000 32.52000  ? 25  THR A HB   1 
ATOM   335  H HG1  . THR A 1 25  ? 29.18900  -25.10800 15.71800  1.000 34.58000  ? 25  THR A HG1  1 
ATOM   336  H HG21 . THR A 1 25  ? 27.00500  -26.62900 13.17000  1.000 29.34000  ? 25  THR A HG21 1 
ATOM   337  H HG22 . THR A 1 25  ? 25.92500  -26.33100 14.28200  1.000 29.34000  ? 25  THR A HG22 1 
ATOM   338  H HG23 . THR A 1 25  ? 26.78200  -25.15100 13.67800  1.000 29.34000  ? 25  THR A HG23 1 
ATOM   339  N N    . VAL A 1 26  ? 27.14800  -24.22400 17.38900  1.000 27.50000  ? 26  VAL A N    1 
ATOM   340  C CA   . VAL A 1 26  ? 26.51600  -22.93100 17.68600  1.000 23.83000  ? 26  VAL A CA   1 
ATOM   341  C C    . VAL A 1 26  ? 26.90400  -21.87300 16.66100  1.000 22.90000  ? 26  VAL A C    1 
ATOM   342  O O    . VAL A 1 26  ? 26.66800  -20.68700 16.88100  1.000 24.86000  ? 26  VAL A O    1 
ATOM   343  C CB   . VAL A 1 26  ? 26.81300  -22.44600 19.12500  1.000 25.32000  ? 26  VAL A CB   1 
ATOM   344  C CG1  . VAL A 1 26  ? 26.19400  -23.34900 20.10100  1.000 26.47000  ? 26  VAL A CG1  1 
ATOM   345  C CG2  . VAL A 1 26  ? 28.33100  -22.28700 19.34400  1.000 27.51000  ? 26  VAL A CG2  1 
ATOM   346  H H    . VAL A 1 26  ? 27.96600  -24.29100 17.64600  1.000 33.02000  ? 26  VAL A H    1 
ATOM   347  H HA   . VAL A 1 26  ? 25.55600  -23.06100 17.62300  1.000 28.62000  ? 26  VAL A HA   1 
ATOM   348  H HB   . VAL A 1 26  ? 26.42100  -21.56900 19.26200  1.000 30.41000  ? 26  VAL A HB   1 
ATOM   349  H HG11 . VAL A 1 26  ? 26.37800  -23.02200 20.99500  1.000 31.78000  ? 26  VAL A HG11 1 
ATOM   350  H HG12 . VAL A 1 26  ? 25.23700  -23.37200 19.94700  1.000 31.78000  ? 26  VAL A HG12 1 
ATOM   351  H HG13 . VAL A 1 26  ? 26.56800  -24.23700 19.99000  1.000 31.78000  ? 26  VAL A HG13 1 
ATOM   352  H HG21 . VAL A 1 26  ? 28.48100  -21.66200 20.07100  1.000 33.03000  ? 26  VAL A HG21 1 
ATOM   353  H HG22 . VAL A 1 26  ? 28.71000  -23.15100 19.56800  1.000 33.03000  ? 26  VAL A HG22 1 
ATOM   354  H HG23 . VAL A 1 26  ? 28.73400  -21.95000 18.52900  1.000 33.03000  ? 26  VAL A HG23 1 
ATOM   355  N N    . TYR A 1 27  ? 27.36700  -22.28200 15.49100  1.000 22.84000  ? 27  TYR A N    1 
ATOM   356  C CA   . TYR A 1 27  ? 27.59900  -21.36700 14.38600  1.000 20.99000  ? 27  TYR A CA   1 
ATOM   357  C C    . TYR A 1 27  ? 26.47600  -20.34500 14.21000  1.000 23.20000  ? 27  TYR A C    1 
ATOM   358  O O    . TYR A 1 27  ? 25.28400  -20.69400 14.29400  1.000 26.71000  ? 27  TYR A O    1 
ATOM   359  C CB   . TYR A 1 27  ? 27.72300  -22.22100 13.07900  1.000 24.75000  ? 27  TYR A CB   1 
ATOM   360  C CG   . TYR A 1 27  ? 27.90600  -21.43700 11.81600  1.000 21.88000  ? 27  TYR A CG   1 
ATOM   361  C CD1  . TYR A 1 27  ? 29.08100  -20.76100 11.56300  1.000 25.26000  ? 27  TYR A CD1  1 
ATOM   362  C CD2  . TYR A 1 27  ? 26.90500  -21.37300 10.85300  1.000 26.44000  ? 27  TYR A CD2  1 
ATOM   363  C CE1  . TYR A 1 27  ? 29.24200  -20.02100 10.44000  1.000 29.63000  ? 27  TYR A CE1  1 
ATOM   364  C CE2  . TYR A 1 27  ? 27.06500  -20.65500 9.73900   1.000 25.04000  ? 27  TYR A CE2  1 
ATOM   365  C CZ   . TYR A 1 27  ? 28.23900  -20.01300 9.46900   1.000 26.99000  ? 27  TYR A CZ   1 
ATOM   366  O OH   . TYR A 1 27  ? 28.39400  -19.27200 8.33000   1.000 27.08000  ? 27  TYR A OH   1 
ATOM   367  H H    . TYR A 1 27  ? 27.55900  -23.10000 15.30700  1.000 27.42000  ? 27  TYR A H    1 
ATOM   368  H HA   . TYR A 1 27  ? 28.40900  -20.86200 14.55700  1.000 25.21000  ? 27  TYR A HA   1 
ATOM   369  H HB2  . TYR A 1 27  ? 28.49000  -22.80800 13.16900  1.000 29.72000  ? 27  TYR A HB2  1 
ATOM   370  H HB3  . TYR A 1 27  ? 26.91400  -22.74600 12.97800  1.000 29.72000  ? 27  TYR A HB3  1 
ATOM   371  H HD1  . TYR A 1 27  ? 29.77800  -20.81500 12.17700  1.000 30.33000  ? 27  TYR A HD1  1 
ATOM   372  H HD2  . TYR A 1 27  ? 26.11000  -21.83700 10.98800  1.000 31.75000  ? 27  TYR A HD2  1 
ATOM   373  H HE1  . TYR A 1 27  ? 30.01700  -19.52000 10.31700  1.000 35.58000  ? 27  TYR A HE1  1 
ATOM   374  H HE2  . TYR A 1 27  ? 26.36200  -20.59100 9.13300   1.000 30.07000  ? 27  TYR A HE2  1 
ATOM   375  H HH   . TYR A 1 27  ? 29.10200  -18.82300 8.37300   1.000 32.51000  ? 27  TYR A HH   1 
ATOM   376  N N    . SER A 1 28  ? 26.83500  -19.09500 13.89600  1.000 21.60000  ? 28  SER A N    1 
ATOM   377  C CA   . SER A 1 28  ? 25.85200  -18.01500 13.98400  1.000 22.31000  ? 28  SER A CA   1 
ATOM   378  C C    . SER A 1 28  ? 24.91800  -17.90400 12.78500  1.000 28.16000  ? 28  SER A C    1 
ATOM   379  O O    . SER A 1 28  ? 23.77300  -17.49500 12.95600  1.000 35.50000  ? 28  SER A O    1 
ATOM   380  C CB   . SER A 1 28  ? 26.54500  -16.66200 14.16400  1.000 29.72000  ? 28  SER A CB   1 
ATOM   381  O OG   . SER A 1 28  ? 27.30600  -16.74300 15.36600  1.000 31.77000  ? 28  SER A OG   1 
ATOM   382  H H    . SER A 1 28  ? 27.61900  -18.85500 13.63600  1.000 25.94000  ? 28  SER A H    1 
ATOM   383  H HA   . SER A 1 28  ? 25.31200  -18.21900 14.76300  1.000 26.79000  ? 28  SER A HA   1 
ATOM   384  H HB2  . SER A 1 28  ? 27.13100  -16.48700 13.41100  1.000 35.68000  ? 28  SER A HB2  1 
ATOM   385  H HB3  . SER A 1 28  ? 25.88200  -15.95700 14.23800  1.000 35.68000  ? 28  SER A HB3  1 
ATOM   386  H HG   . SER A 1 28  ? 27.88000  -17.35300 15.30200  1.000 38.14000  ? 28  SER A HG   1 
ATOM   387  N N    . ASN A 1 29  ? 25.36900  -18.21800 11.59200  1.000 22.25000  ? 29  ASN A N    1 
ATOM   388  C CA   . ASN A 1 29  ? 24.62800  -17.86300 10.36900  1.000 21.52000  ? 29  ASN A CA   1 
ATOM   389  C C    . ASN A 1 29  ? 23.84100  -19.06900 9.83500   1.000 22.63000  ? 29  ASN A C    1 
ATOM   390  O O    . ASN A 1 29  ? 24.08000  -19.56700 8.75300   1.000 23.16000  ? 29  ASN A O    1 
ATOM   391  C CB   . ASN A 1 29  ? 25.58700  -17.32200 9.29100   1.000 23.97000  ? 29  ASN A CB   1 
ATOM   392  C CG   . ASN A 1 29  ? 26.47100  -16.23800 9.80500   1.000 41.97000  ? 29  ASN A CG   1 
ATOM   393  O OD1  . ASN A 1 29  ? 25.97200  -15.27200 10.40900  1.000 39.99000  ? 29  ASN A OD1  1 
ATOM   394  N ND2  . ASN A 1 29  ? 27.77200  -16.33200 9.52800   1.000 41.61000  ? 29  ASN A ND2  1 
ATOM   395  H H    . ASN A 1 29  ? 26.10400  -18.64000 11.44800  1.000 26.72000  ? 29  ASN A H    1 
ATOM   396  H HA   . ASN A 1 29  ? 23.99700  -17.16300 10.59700  1.000 25.84000  ? 29  ASN A HA   1 
ATOM   397  H HB2  . ASN A 1 29  ? 26.15100  -18.04600 8.97700   1.000 28.78000  ? 29  ASN A HB2  1 
ATOM   398  H HB3  . ASN A 1 29  ? 25.06700  -16.96300 8.55600   1.000 28.78000  ? 29  ASN A HB3  1 
ATOM   399  H HD21 . ASN A 1 29  ? 28.06800  -16.99900 9.07200   1.000 49.95000  ? 29  ASN A HD21 1 
ATOM   400  H HD22 . ASN A 1 29  ? 28.31600  -15.72700 9.80700   1.000 49.95000  ? 29  ASN A HD22 1 
ATOM   401  N N    . LYS A 1 30  ? 22.91600  -19.54600 10.65900  1.000 20.48000  ? 30  LYS A N    1 
ATOM   402  C CA   . LYS A 1 30  ? 22.17300  -20.76000 10.34700  1.000 22.52000  ? 30  LYS A CA   1 
ATOM   403  C C    . LYS A 1 30  ? 21.39000  -20.62300 9.05500   1.000 21.64000  ? 30  LYS A C    1 
ATOM   404  O O    . LYS A 1 30  ? 21.10800  -21.67200 8.42400   1.000 19.70000  ? 30  LYS A O    1 
ATOM   405  C CB   . LYS A 1 30  ? 21.25600  -21.10800 11.47800  1.000 21.29000  ? 30  LYS A CB   1 
ATOM   406  C CG   . LYS A 1 30  ? 21.96500  -21.54500 12.82900  1.000 24.96000  ? 30  LYS A CG   1 
ATOM   407  C CD   . LYS A 1 30  ? 20.91400  -21.81900 13.86000  1.000 27.31000  ? 30  LYS A CD   1 
ATOM   408  C CE   . LYS A 1 30  ? 21.49900  -22.29400 15.18600  1.000 34.97000  ? 30  LYS A CE   1 
ATOM   409  N NZ   . LYS A 1 30  ? 21.85700  -23.69600 15.11400  1.000 32.29000  ? 30  LYS A NZ   1 
ATOM   410  H H    . LYS A 1 30  ? 22.69800  -19.18500 11.40900  1.000 24.60000  ? 30  LYS A H    1 
ATOM   411  H HA   . LYS A 1 30  ? 22.79700  -21.49500 10.24100  1.000 27.04000  ? 30  LYS A HA   1 
ATOM   412  H HB2  . LYS A 1 30  ? 20.71100  -20.33100 11.67700  1.000 25.57000  ? 30  LYS A HB2  1 
ATOM   413  H HB3  . LYS A 1 30  ? 20.69300  -21.84600 11.19700  1.000 25.57000  ? 30  LYS A HB3  1 
ATOM   414  H HG2  . LYS A 1 30  ? 22.48400  -22.35100 12.68400  1.000 29.97000  ? 30  LYS A HG2  1 
ATOM   415  H HG3  . LYS A 1 30  ? 22.54100  -20.83200 13.14600  1.000 29.97000  ? 30  LYS A HG3  1 
ATOM   416  H HD2  . LYS A 1 30  ? 20.41500  -21.00400 14.02800  1.000 32.79000  ? 30  LYS A HD2  1 
ATOM   417  H HD3  . LYS A 1 30  ? 20.32000  -22.51000 13.53000  1.000 32.79000  ? 30  LYS A HD3  1 
ATOM   418  H HE2  . LYS A 1 30  ? 22.29700  -21.78200 15.39100  1.000 41.98000  ? 30  LYS A HE2  1 
ATOM   419  H HE3  . LYS A 1 30  ? 20.84100  -22.18000 15.89000  1.000 41.98000  ? 30  LYS A HE3  1 
ATOM   420  H HZ1  . LYS A 1 30  ? 21.12300  -24.19500 15.05200  1.000 38.77000  ? 30  LYS A HZ1  1 
ATOM   421  H HZ2  . LYS A 1 30  ? 22.36800  -23.84400 14.40100  1.000 38.77000  ? 30  LYS A HZ2  1 
ATOM   422  H HZ3  . LYS A 1 30  ? 22.30600  -23.93300 15.84500  1.000 38.77000  ? 30  LYS A HZ3  1 
ATOM   423  N N    . GLU A 1 31  ? 21.04600  -19.40400 8.65100   1.000 18.06000  ? 31  GLU A N    1 
ATOM   424  C CA   . GLU A 1 31  ? 20.20000  -19.21400 7.47300   1.000 17.83000  ? 31  GLU A CA   1 
ATOM   425  C C    . GLU A 1 31  ? 20.78400  -19.74200 6.17700   1.000 18.97000  ? 31  GLU A C    1 
ATOM   426  O O    . GLU A 1 31  ? 20.01900  -19.91000 5.21500   1.000 18.81000  ? 31  GLU A O    1 
ATOM   427  C CB   . GLU A 1 31  ? 19.85100  -17.75700 7.28200   1.000 20.45000  ? 31  GLU A CB   1 
ATOM   428  C CG   . GLU A 1 31  ? 21.01500  -16.92300 6.78600   1.000 20.36000  ? 31  GLU A CG   1 
ATOM   429  C CD   . GLU A 1 31  ? 20.75700  -15.40000 6.95500   1.000 30.45000  ? 31  GLU A CD   1 
ATOM   430  O OE1  . GLU A 1 31  ? 20.56100  -14.95800 8.09700   1.000 37.49000  ? 31  GLU A OE1  1 
ATOM   431  O OE2  . GLU A 1 31  ? 20.91500  -14.65800 5.97200   1.000 38.41000  ? 31  GLU A OE2  1 
ATOM   432  H H    . GLU A 1 31  ? 21.28700  -18.67400 9.03700   1.000 21.69000  ? 31  GLU A H    1 
ATOM   433  H HA   . GLU A 1 31  ? 19.38900  -19.71600 7.65300   1.000 21.42000  ? 31  GLU A HA   1 
ATOM   434  H HB2  . GLU A 1 31  ? 19.13600  -17.68900 6.63000   1.000 24.56000  ? 31  GLU A HB2  1 
ATOM   435  H HB3  . GLU A 1 31  ? 19.56100  -17.38900 8.13200   1.000 24.56000  ? 31  GLU A HB3  1 
ATOM   436  H HG2  . GLU A 1 31  ? 21.81000  -17.15300 7.29100   1.000 24.46000  ? 31  GLU A HG2  1 
ATOM   437  H HG3  . GLU A 1 31  ? 21.15700  -17.10200 5.84300   1.000 24.46000  ? 31  GLU A HG3  1 
ATOM   438  N N    . ILE A 1 32  ? 22.09100  -20.04500 6.10600   1.000 17.82000  ? 32  ILE A N    1 
ATOM   439  C CA   . ILE A 1 32  ? 22.68300  -20.53500 4.88300   1.000 19.21000  ? 32  ILE A CA   1 
ATOM   440  C C    . ILE A 1 32  ? 22.13600  -21.91500 4.54000   1.000 17.28000  ? 32  ILE A C    1 
ATOM   441  O O    . ILE A 1 32  ? 22.30500  -22.38500 3.39600   1.000 18.46000  ? 32  ILE A O    1 
ATOM   442  C CB   . ILE A 1 32  ? 24.23400  -20.58300 4.96900   1.000 25.39000  ? 32  ILE A CB   1 
ATOM   443  C CG1  . ILE A 1 32  ? 24.68500  -21.52800 6.03600   1.000 24.39000  ? 32  ILE A CG1  1 
ATOM   444  C CG2  . ILE A 1 32  ? 24.75700  -19.19700 5.22500   1.000 29.49000  ? 32  ILE A CG2  1 
ATOM   445  C CD1  . ILE A 1 32  ? 25.07500  -22.95700 5.60800   1.000 28.45000  ? 32  ILE A CD1  1 
ATOM   446  H H    . ILE A 1 32  ? 22.64400  -19.97000 6.75900   1.000 21.40000  ? 32  ILE A H    1 
ATOM   447  H HA   . ILE A 1 32  ? 22.47100  -19.91600 4.16800   1.000 23.07000  ? 32  ILE A HA   1 
ATOM   448  H HB   . ILE A 1 32  ? 24.58500  -20.91100 4.12700   1.000 30.49000  ? 32  ILE A HB   1 
ATOM   449  H HG12 . ILE A 1 32  ? 25.46500  -21.14200 6.46400   1.000 29.28000  ? 32  ILE A HG12 1 
ATOM   450  H HG13 . ILE A 1 32  ? 23.96300  -21.61600 6.67900   1.000 29.28000  ? 32  ILE A HG13 1 
ATOM   451  H HG21 . ILE A 1 32  ? 25.72400  -19.20400 5.14400   1.000 35.41000  ? 32  ILE A HG21 1 
ATOM   452  H HG22 . ILE A 1 32  ? 24.37500  -18.59000 4.57200   1.000 35.41000  ? 32  ILE A HG22 1 
ATOM   453  H HG23 . ILE A 1 32  ? 24.50200  -18.92300 6.12000   1.000 35.41000  ? 32  ILE A HG23 1 
ATOM   454  H HD11 . ILE A 1 32  ? 25.47500  -23.41500 6.36400   1.000 34.15000  ? 32  ILE A HD11 1 
ATOM   455  H HD12 . ILE A 1 32  ? 24.27800  -23.42900 5.32000   1.000 34.15000  ? 32  ILE A HD12 1 
ATOM   456  H HD13 . ILE A 1 32  ? 25.71100  -22.90500 4.87800   1.000 34.15000  ? 32  ILE A HD13 1 
ATOM   457  N N    . PHE A 1 33  ? 21.45200  -22.59300 5.47400   1.000 16.64000  ? 33  PHE A N    1 
ATOM   458  C CA   . PHE A 1 33  ? 20.84200  -23.88900 5.13400   1.000 17.17000  ? 33  PHE A CA   1 
ATOM   459  C C    . PHE A 1 33  ? 19.95400  -23.71400 3.90600   1.000 17.83000  ? 33  PHE A C    1 
ATOM   460  O O    . PHE A 1 33  ? 19.85900  -24.62800 3.07000   1.000 16.30000  ? 33  PHE A O    1 
ATOM   461  C CB   . PHE A 1 33  ? 20.02700  -24.48600 6.33300   1.000 15.57000  ? 33  PHE A CB   1 
ATOM   462  C CG   . PHE A 1 33  ? 18.63100  -23.97900 6.41800   1.000 15.80000  ? 33  PHE A CG   1 
ATOM   463  C CD1  . PHE A 1 33  ? 18.31800  -22.79800 7.13400   1.000 18.32000  ? 33  PHE A CD1  1 
ATOM   464  C CD2  . PHE A 1 33  ? 17.57000  -24.66000 5.77600   1.000 15.82000  ? 33  PHE A CD2  1 
ATOM   465  C CE1  . PHE A 1 33  ? 17.07000  -22.29400 7.15900   1.000 17.46000  ? 33  PHE A CE1  1 
ATOM   466  C CE2  . PHE A 1 33  ? 16.30900  -24.15600 5.82700   1.000 15.56000  ? 33  PHE A CE2  1 
ATOM   467  C CZ   . PHE A 1 33  ? 16.03000  -22.95800 6.51800   1.000 17.36000  ? 33  PHE A CZ   1 
ATOM   468  H H    . PHE A 1 33  ? 21.32900  -22.33500 6.28500   1.000 19.99000  ? 33  PHE A H    1 
ATOM   469  H HA   . PHE A 1 33  ? 21.54300  -24.53300 4.94800   1.000 20.62000  ? 33  PHE A HA   1 
ATOM   470  H HB2  . PHE A 1 33  ? 19.98700  -25.45000 6.23300   1.000 18.70000  ? 33  PHE A HB2  1 
ATOM   471  H HB3  . PHE A 1 33  ? 20.47700  -24.25600 7.16100   1.000 18.70000  ? 33  PHE A HB3  1 
ATOM   472  H HD1  . PHE A 1 33  ? 18.99200  -22.36000 7.60100   1.000 22.00000  ? 33  PHE A HD1  1 
ATOM   473  H HD2  . PHE A 1 33  ? 17.73500  -25.45300 5.31800   1.000 19.00000  ? 33  PHE A HD2  1 
ATOM   474  H HE1  . PHE A 1 33  ? 16.90300  -21.49600 7.60600   1.000 20.97000  ? 33  PHE A HE1  1 
ATOM   475  H HE2  . PHE A 1 33  ? 15.61800  -24.60800 5.39900   1.000 18.69000  ? 33  PHE A HE2  1 
ATOM   476  H HZ   . PHE A 1 33  ? 15.16500  -22.61800 6.54600   1.000 20.85000  ? 33  PHE A HZ   1 
ATOM   477  N N    . LEU A 1 34  ? 19.20300  -22.61800 3.83400   1.000 16.47000  ? 34  LEU A N    1 
ATOM   478  C CA   . LEU A 1 34  ? 18.22900  -22.51800 2.75800   1.000 15.09000  ? 34  LEU A CA   1 
ATOM   479  C C    . LEU A 1 34  ? 18.93100  -22.36500 1.40400   1.000 17.43000  ? 34  LEU A C    1 
ATOM   480  O O    . LEU A 1 34  ? 18.49300  -22.90800 0.38100   1.000 15.95000  ? 34  LEU A O    1 
ATOM   481  C CB   . LEU A 1 34  ? 17.25500  -21.38300 3.03100   1.000 15.85000  ? 34  LEU A CB   1 
ATOM   482  C CG   . LEU A 1 34  ? 16.05900  -21.23600 2.08500   1.000 16.49000  ? 34  LEU A CG   1 
ATOM   483  C CD1  . LEU A 1 34  ? 15.18200  -22.49400 2.06300   1.000 18.40000  ? 34  LEU A CD1  1 
ATOM   484  C CD2  . LEU A 1 34  ? 15.26000  -20.04200 2.51000   1.000 19.24000  ? 34  LEU A CD2  1 
ATOM   485  H H    . LEU A 1 34  ? 19.23800  -21.94900 4.37300   1.000 19.79000  ? 34  LEU A H    1 
ATOM   486  H HA   . LEU A 1 34  ? 17.70100  -23.33100 2.72100   1.000 18.12000  ? 34  LEU A HA   1 
ATOM   487  H HB2  . LEU A 1 34  ? 16.89400  -21.51000 3.92200   1.000 19.04000  ? 34  LEU A HB2  1 
ATOM   488  H HB3  . LEU A 1 34  ? 17.75100  -20.55000 2.98900   1.000 19.04000  ? 34  LEU A HB3  1 
ATOM   489  H HG   . LEU A 1 34  ? 16.38100  -21.11400 1.17800   1.000 19.81000  ? 34  LEU A HG   1 
ATOM   490  H HD11 . LEU A 1 34  ? 14.32400  -22.27400 1.66700   1.000 22.10000  ? 34  LEU A HD11 1 
ATOM   491  H HD12 . LEU A 1 34  ? 15.62300  -23.17800 1.53500   1.000 22.10000  ? 34  LEU A HD12 1 
ATOM   492  H HD13 . LEU A 1 34  ? 15.05600  -22.80800 2.97200   1.000 22.10000  ? 34  LEU A HD13 1 
ATOM   493  H HD21 . LEU A 1 34  ? 14.47000  -19.97600 1.95200   1.000 23.11000  ? 34  LEU A HD21 1 
ATOM   494  H HD22 . LEU A 1 34  ? 15.00100  -20.15000 3.43900   1.000 23.11000  ? 34  LEU A HD22 1 
ATOM   495  H HD23 . LEU A 1 34  ? 15.80400  -19.24600 2.40900   1.000 23.11000  ? 34  LEU A HD23 1 
ATOM   496  N N    . ARG A 1 35  ? 20.01200  -21.57100 1.35300   1.000 16.36000  ? 35  ARG A N    1 
ATOM   497  C CA   . ARG A 1 35  ? 20.80800  -21.44900 0.14700   1.000 17.80000  ? 35  ARG A CA   1 
ATOM   498  C C    . ARG A 1 35  ? 21.28200  -22.81300 -0.32500  1.000 15.10000  ? 35  ARG A C    1 
ATOM   499  O O    . ARG A 1 35  ? 21.21000  -23.12100 -1.52200  1.000 16.62000  ? 35  ARG A O    1 
ATOM   500  C CB   . ARG A 1 35  ? 22.03200  -20.53800 0.44700   1.000 19.59000  ? 35  ARG A CB   1 
ATOM   501  C CG   . ARG A 1 35  ? 22.95600  -20.39300 -0.77300  1.000 22.02000  ? 35  ARG A CG   1 
ATOM   502  C CD   . ARG A 1 35  ? 24.30900  -19.75700 -0.35500  1.000 24.78000  ? 35  ARG A CD   1 
ATOM   503  N NE   . ARG A 1 35  ? 25.06900  -20.70500 0.45100   1.000 24.99000  ? 35  ARG A NE   1 
ATOM   504  C CZ   . ARG A 1 35  ? 26.03800  -20.34500 1.26900   1.000 27.72000  ? 35  ARG A CZ   1 
ATOM   505  N NH1  . ARG A 1 35  ? 26.35400  -19.08500 1.41000   1.000 31.32000  ? 35  ARG A NH1  1 
ATOM   506  N NH2  . ARG A 1 35  ? 26.65900  -21.27200 1.99200   1.000 34.02000  ? 35  ARG A NH2  1 
ATOM   507  H H    . ARG A 1 35  ? 20.29800  -21.09600 2.01000   1.000 19.65000  ? 35  ARG A H    1 
ATOM   508  H HA   . ARG A 1 35  ? 20.27500  -21.04800 -0.55800  1.000 21.37000  ? 35  ARG A HA   1 
ATOM   509  H HB2  . ARG A 1 35  ? 21.71900  -19.65500 0.69700   1.000 23.53000  ? 35  ARG A HB2  1 
ATOM   510  H HB3  . ARG A 1 35  ? 22.54700  -20.92600 1.17200   1.000 23.53000  ? 35  ARG A HB3  1 
ATOM   511  H HG2  . ARG A 1 35  ? 23.13100  -21.26700 -1.15500  1.000 26.44000  ? 35  ARG A HG2  1 
ATOM   512  H HG3  . ARG A 1 35  ? 22.53600  -19.82000 -1.43300  1.000 26.44000  ? 35  ARG A HG3  1 
ATOM   513  H HD2  . ARG A 1 35  ? 24.82500  -19.53500 -1.14600  1.000 29.76000  ? 35  ARG A HD2  1 
ATOM   514  H HD3  . ARG A 1 35  ? 24.14700  -18.95800 0.17100   1.000 29.76000  ? 35  ARG A HD3  1 
ATOM   515  H HE   . ARG A 1 35  ? 24.87600  -21.54100 0.39000   1.000 30.00000  ? 35  ARG A HE   1 
ATOM   516  H HH11 . ARG A 1 35  ? 25.92900  -18.48300 0.96700   1.000 37.60000  ? 35  ARG A HH11 1 
ATOM   517  H HH12 . ARG A 1 35  ? 26.98800  -18.85800 1.94500   1.000 37.60000  ? 35  ARG A HH12 1 
ATOM   518  H HH21 . ARG A 1 35  ? 26.42700  -22.09800 1.92300   1.000 40.84000  ? 35  ARG A HH21 1 
ATOM   519  H HH22 . ARG A 1 35  ? 27.29200  -21.04700 2.52800   1.000 40.84000  ? 35  ARG A HH22 1 
ATOM   520  N N    . GLU A 1 36  ? 21.76300  -23.65000 0.59300   1.000 15.11000  ? 36  GLU A N    1 
ATOM   521  C CA   . GLU A 1 36  ? 22.28500  -24.95000 0.24100   1.000 14.33000  ? 36  GLU A CA   1 
ATOM   522  C C    . GLU A 1 36  ? 21.20000  -25.84500 -0.33900  1.000 15.85000  ? 36  GLU A C    1 
ATOM   523  O O    . GLU A 1 36  ? 21.43500  -26.57000 -1.28700  1.000 16.98000  ? 36  GLU A O    1 
ATOM   524  C CB   . GLU A 1 36  ? 22.92700  -25.60500 1.46500   1.000 17.42000  ? 36  GLU A CB   1 
ATOM   525  C CG   . GLU A 1 36  ? 24.25400  -24.86200 1.91600   1.000 18.60000  ? 36  GLU A CG   1 
ATOM   526  C CD   . GLU A 1 36  ? 25.23400  -24.68900 0.82000   1.000 25.88000  ? 36  GLU A CD   1 
ATOM   527  O OE1  . GLU A 1 36  ? 25.45300  -25.66200 0.10700   1.000 25.30000  ? 36  GLU A OE1  1 
ATOM   528  O OE2  . GLU A 1 36  ? 25.83400  -23.57200 0.83600   1.000 29.63000  ? 36  GLU A OE2  1 
ATOM   529  H H    . GLU A 1 36  ? 21.79600  -23.48100 1.43500   1.000 18.15000  ? 36  GLU A H    1 
ATOM   530  H HA   . GLU A 1 36  ? 22.97200  -24.83700 -0.43500  1.000 17.22000  ? 36  GLU A HA   1 
ATOM   531  H HB2  . GLU A 1 36  ? 22.29900  -25.57900 2.20400   1.000 20.93000  ? 36  GLU A HB2  1 
ATOM   532  H HB3  . GLU A 1 36  ? 23.15200  -26.52400 1.25200   1.000 20.93000  ? 36  GLU A HB3  1 
ATOM   533  H HG2  . GLU A 1 36  ? 24.02200  -23.98000 2.24900   1.000 22.34000  ? 36  GLU A HG2  1 
ATOM   534  H HG3  . GLU A 1 36  ? 24.68000  -25.37900 2.61700   1.000 22.34000  ? 36  GLU A HG3  1 
ATOM   535  N N    . LEU A 1 37  ? 20.01200  -25.81700 0.26100   1.000 16.23000  ? 37  LEU A N    1 
ATOM   536  C CA   . LEU A 1 37  ? 18.92300  -26.67900 -0.23200  1.000 15.59000  ? 37  LEU A CA   1 
ATOM   537  C C    . LEU A 1 37  ? 18.37700  -26.15400 -1.56400  1.000 14.32000  ? 37  LEU A C    1 
ATOM   538  O O    . LEU A 1 37  ? 17.93200  -26.96400 -2.39900  1.000 14.89000  ? 37  LEU A O    1 
ATOM   539  C CB   . LEU A 1 37  ? 17.82100  -26.79500 0.82700   1.000 15.55000  ? 37  LEU A CB   1 
ATOM   540  C CG   . LEU A 1 37  ? 18.31100  -27.37600 2.14900   1.000 19.61000  ? 37  LEU A CG   1 
ATOM   541  C CD1  . LEU A 1 37  ? 17.04600  -27.51200 3.05700   1.000 20.63000  ? 37  LEU A CD1  1 
ATOM   542  C CD2  . LEU A 1 37  ? 19.02900  -28.72200 2.04900   1.000 21.16000  ? 37  LEU A CD2  1 
ATOM   543  H H    . LEU A 1 37  ? 19.80900  -25.32400 0.93700   1.000 19.49000  ? 37  LEU A H    1 
ATOM   544  H HA   . LEU A 1 37  ? 19.25700  -27.57700 -0.38400  1.000 18.73000  ? 37  LEU A HA   1 
ATOM   545  H HB2  . LEU A 1 37  ? 17.46200  -25.91200 1.00400   1.000 18.67000  ? 37  LEU A HB2  1 
ATOM   546  H HB3  . LEU A 1 37  ? 17.12100  -27.37500 0.48800   1.000 18.67000  ? 37  LEU A HB3  1 
ATOM   547  H HG   . LEU A 1 37  ? 18.98600  -26.78300 2.51500   1.000 23.55000  ? 37  LEU A HG   1 
ATOM   548  H HD11 . LEU A 1 37  ? 17.32100  -27.80300 3.94100   1.000 24.77000  ? 37  LEU A HD11 1 
ATOM   549  H HD12 . LEU A 1 37  ? 16.60500  -26.65000 3.11600   1.000 24.77000  ? 37  LEU A HD12 1 
ATOM   550  H HD13 . LEU A 1 37  ? 16.44500  -28.16500 2.66600   1.000 24.77000  ? 37  LEU A HD13 1 
ATOM   551  H HD21 . LEU A 1 37  ? 19.19600  -29.05700 2.94400   1.000 25.41000  ? 37  LEU A HD21 1 
ATOM   552  H HD22 . LEU A 1 37  ? 18.46700  -29.34400 1.56200   1.000 25.41000  ? 37  LEU A HD22 1 
ATOM   553  H HD23 . LEU A 1 37  ? 19.86900  -28.59700 1.58000   1.000 25.41000  ? 37  LEU A HD23 1 
ATOM   554  N N    . ILE A 1 38  ? 18.33000  -24.82800 -1.78200  1.000 14.69000  ? 38  ILE A N    1 
ATOM   555  C CA   . ILE A 1 38  ? 17.88800  -24.29400 -3.05700  1.000 13.81000  ? 38  ILE A CA   1 
ATOM   556  C C    . ILE A 1 38  ? 18.92900  -24.64500 -4.12600  1.000 14.58000  ? 38  ILE A C    1 
ATOM   557  O O    . ILE A 1 38  ? 18.58300  -25.00600 -5.25200  1.000 15.24000  ? 38  ILE A O    1 
ATOM   558  C CB   . ILE A 1 38  ? 17.63700  -22.77900 -2.93000  1.000 14.68000  ? 38  ILE A CB   1 
ATOM   559  C CG1  . ILE A 1 38  ? 16.36900  -22.53100 -2.13300  1.000 15.83000  ? 38  ILE A CG1  1 
ATOM   560  C CG2  . ILE A 1 38  ? 17.59100  -22.09900 -4.26800  1.000 16.55000  ? 38  ILE A CG2  1 
ATOM   561  C CD1  . ILE A 1 38  ? 16.15900  -21.04600 -1.77300  1.000 18.20000  ? 38  ILE A CD1  1 
ATOM   562  H H    . ILE A 1 38  ? 18.55000  -24.22900 -1.20500  1.000 17.65000  ? 38  ILE A H    1 
ATOM   563  H HA   . ILE A 1 38  ? 17.04400  -24.69300 -3.32100  1.000 16.59000  ? 38  ILE A HA   1 
ATOM   564  H HB   . ILE A 1 38  ? 18.38600  -22.39100 -2.45100  1.000 17.64000  ? 38  ILE A HB   1 
ATOM   565  H HG12 . ILE A 1 38  ? 15.60700  -22.82200 -2.65700  1.000 19.01000  ? 38  ILE A HG12 1 
ATOM   566  H HG13 . ILE A 1 38  ? 16.41500  -23.03600 -1.30600  1.000 19.01000  ? 38  ILE A HG13 1 
ATOM   567  H HG21 . ILE A 1 38  ? 17.29200  -21.18400 -4.14700  1.000 19.88000  ? 38  ILE A HG21 1 
ATOM   568  H HG22 . ILE A 1 38  ? 18.48000  -22.10800 -4.65700  1.000 19.88000  ? 38  ILE A HG22 1 
ATOM   569  H HG23 . ILE A 1 38  ? 16.97300  -22.57600 -4.84400  1.000 19.88000  ? 38  ILE A HG23 1 
ATOM   570  H HD11 . ILE A 1 38  ? 15.49800  -20.98300 -1.06600  1.000 21.85000  ? 38  ILE A HD11 1 
ATOM   571  H HD12 . ILE A 1 38  ? 17.00200  -20.67100 -1.47300  1.000 21.85000  ? 38  ILE A HD12 1 
ATOM   572  H HD13 . ILE A 1 38  ? 15.84800  -20.57100 -2.56000  1.000 21.85000  ? 38  ILE A HD13 1 
ATOM   573  N N    A SER A 1 39  ? 20.22100  -24.63400 -3.75700  0.340 15.45000  ? 39  SER A N    1 
ATOM   574  N N    B SER A 1 39  ? 20.23200  -24.62500 -3.77100  0.660 15.11000  ? 39  SER A N    1 
ATOM   575  C CA   A SER A 1 39  ? 21.26100  -25.02600 -4.70200  0.340 16.64000  ? 39  SER A CA   1 
ATOM   576  C CA   B SER A 1 39  ? 21.24700  -25.04100 -4.73300  0.660 16.06000  ? 39  SER A CA   1 
ATOM   577  C C    A SER A 1 39  ? 21.13600  -26.49000 -5.10500  0.340 15.71000  ? 39  SER A C    1 
ATOM   578  C C    B SER A 1 39  ? 21.13700  -26.50000 -5.11400  0.660 15.69000  ? 39  SER A C    1 
ATOM   579  O O    A SER A 1 39  ? 21.28500  -26.83000 -6.28300  0.340 17.93000  ? 39  SER A O    1 
ATOM   580  O O    B SER A 1 39  ? 21.26300  -26.85100 -6.29200  0.660 18.29000  ? 39  SER A O    1 
ATOM   581  C CB   A SER A 1 39  ? 22.63400  -24.78400 -4.07900  0.340 18.64000  ? 39  SER A CB   1 
ATOM   582  C CB   B SER A 1 39  ? 22.63600  -24.76200 -4.16800  0.660 17.93000  ? 39  SER A CB   1 
ATOM   583  O OG   A SER A 1 39  ? 23.66300  -25.12900 -4.99600  0.340 22.79000  ? 39  SER A OG   1 
ATOM   584  O OG   B SER A 1 39  ? 22.83100  -23.35000 -4.07600  0.660 21.69000  ? 39  SER A OG   1 
ATOM   585  H H    A SER A 1 39  ? 20.51000  -24.40800 -2.97900  0.340 18.56000  ? 39  SER A H    1 
ATOM   586  H H    B SER A 1 39  ? 20.53400  -24.38100 -3.00300  0.660 18.15000  ? 39  SER A H    1 
ATOM   587  H HA   A SER A 1 39  ? 21.16900  -24.48300 -5.50100  0.340 19.99000  ? 39  SER A HA   1 
ATOM   588  H HA   B SER A 1 39  ? 21.11400  -24.52100 -5.54000  0.660 19.29000  ? 39  SER A HA   1 
ATOM   589  H HB2  A SER A 1 39  ? 22.71600  -23.84500 -3.84800  0.340 22.39000  ? 39  SER A HB2  1 
ATOM   590  H HB2  B SER A 1 39  ? 22.71100  -25.15600 -3.28500  0.660 21.54000  ? 39  SER A HB2  1 
ATOM   591  H HB3  A SER A 1 39  ? 22.72200  -25.33000 -3.28300  0.340 22.39000  ? 39  SER A HB3  1 
ATOM   592  H HB3  B SER A 1 39  ? 23.30600  -25.14100 -4.75800  0.660 21.54000  ? 39  SER A HB3  1 
ATOM   593  H HG   A SER A 1 39  ? 23.73900  -25.96400 -5.04200  0.340 27.36000  ? 39  SER A HG   1 
ATOM   594  H HG   B SER A 1 39  ? 22.68300  -23.09100 -3.29100  0.660 26.05000  ? 39  SER A HG   1 
ATOM   595  N N    . ASN A 1 40  ? 20.84000  -27.37800 -4.14300  1.000 15.50000  ? 40  ASN A N    1 
ATOM   596  C CA   . ASN A 1 40  ? 20.62000  -28.77800 -4.47900  1.000 14.43000  ? 40  ASN A CA   1 
ATOM   597  C C    . ASN A 1 40  ? 19.42300  -28.93900 -5.40100  1.000 16.31000  ? 40  ASN A C    1 
ATOM   598  O O    . ASN A 1 40  ? 19.46800  -29.72400 -6.35400  1.000 15.87000  ? 40  ASN A O    1 
ATOM   599  C CB   . ASN A 1 40  ? 20.39700  -29.57900 -3.22500  1.000 16.09000  ? 40  ASN A CB   1 
ATOM   600  C CG   . ASN A 1 40  ? 21.66800  -29.85100 -2.43000  1.000 19.50000  ? 40  ASN A CG   1 
ATOM   601  O OD1  . ASN A 1 40  ? 22.76600  -29.50700 -2.83700  1.000 22.23000  ? 40  ASN A OD1  1 
ATOM   602  N ND2  . ASN A 1 40  ? 21.46200  -30.34100 -1.23300  1.000 23.92000  ? 40  ASN A ND2  1 
ATOM   603  H H    . ASN A 1 40  ? 20.76400  -27.18400 -3.30900  1.000 18.62000  ? 40  ASN A H    1 
ATOM   604  H HA   . ASN A 1 40  ? 21.41100  -29.11500 -4.92800  1.000 17.34000  ? 40  ASN A HA   1 
ATOM   605  H HB2  . ASN A 1 40  ? 19.78700  -29.09100 -2.64900  1.000 19.33000  ? 40  ASN A HB2  1 
ATOM   606  H HB3  . ASN A 1 40  ? 20.01100  -30.43500 -3.46700  1.000 19.33000  ? 40  ASN A HB3  1 
ATOM   607  H HD21 . ASN A 1 40  ? 20.65900  -30.48200 -0.95900  1.000 28.72000  ? 40  ASN A HD21 1 
ATOM   608  H HD22 . ASN A 1 40  ? 22.13000  -30.52200 -0.72200  1.000 28.72000  ? 40  ASN A HD22 1 
ATOM   609  N N    . ALA A 1 41  ? 18.35800  -28.19400 -5.14100  1.000 13.46000  ? 41  ALA A N    1 
ATOM   610  C CA   . ALA A 1 41  ? 17.18500  -28.26100 -6.00900  1.000 13.85000  ? 41  ALA A CA   1 
ATOM   611  C C    . ALA A 1 41  ? 17.51300  -27.79200 -7.41200  1.000 13.66000  ? 41  ALA A C    1 
ATOM   612  O O    . ALA A 1 41  ? 17.09000  -28.40800 -8.39400  1.000 14.70000  ? 41  ALA A O    1 
ATOM   613  C CB   . ALA A 1 41  ? 16.06200  -27.43700 -5.40500  1.000 14.11000  ? 41  ALA A CB   1 
ATOM   614  H H    . ALA A 1 41  ? 18.28500  -27.64900 -4.48000  1.000 16.17000  ? 41  ALA A H    1 
ATOM   615  H HA   . ALA A 1 41  ? 16.88300  -29.18000 -6.07400  1.000 16.64000  ? 41  ALA A HA   1 
ATOM   616  H HB1  . ALA A 1 41  ? 15.35300  -27.34100 -6.06000  1.000 16.95000  ? 41  ALA A HB1  1 
ATOM   617  H HB2  . ALA A 1 41  ? 15.72500  -27.89300 -4.61800  1.000 16.95000  ? 41  ALA A HB2  1 
ATOM   618  H HB3  . ALA A 1 41  ? 16.40700  -26.56400 -5.16000  1.000 16.95000  ? 41  ALA A HB3  1 
ATOM   619  N N    . SER A 1 42  ? 18.23900  -26.68900 -7.50000  1.000 14.44000  ? 42  SER A N    1 
ATOM   620  C CA   . SER A 1 42  ? 18.62100  -26.12300 -8.80900  1.000 13.43000  ? 42  SER A CA   1 
ATOM   621  C C    . SER A 1 42  ? 19.47900  -27.13200 -9.57400  1.000 14.14000  ? 42  SER A C    1 
ATOM   622  O O    . SER A 1 42  ? 19.35400  -27.17300 -10.73900 1.000 16.68000  ? 42  SER A O    1 
ATOM   623  C CB   . SER A 1 42  ? 19.35200  -24.81800 -8.62800  1.000 15.57000  ? 42  SER A CB   1 
ATOM   624  O OG   . SER A 1 42  ? 19.78500  -24.31000 -9.87600  1.000 17.95000  ? 42  SER A OG   1 
ATOM   625  H H    . SER A 1 42  ? 18.55500  -26.24900 -6.77900  1.000 17.35000  ? 42  SER A H    1 
ATOM   626  H HA   . SER A 1 42  ? 17.79500  -25.95400 -9.33100  1.000 16.14000  ? 42  SER A HA   1 
ATOM   627  H HB2  . SER A 1 42  ? 18.75800  -24.17300 -8.19800  1.000 18.70000  ? 42  SER A HB2  1 
ATOM   628  H HB3  . SER A 1 42  ? 20.12400  -24.96000 -8.04800  1.000 18.70000  ? 42  SER A HB3  1 
ATOM   629  H HG   . SER A 1 42  ? 19.90600  -23.47800 -9.79500  1.000 21.56000  ? 42  SER A HG   1 
ATOM   630  N N    . ASP A 1 43  ? 20.35200  -27.84200 -8.89000  1.000 15.21000  ? 43  ASP A N    1 
ATOM   631  C CA   . ASP A 1 43  ? 21.22800  -28.84500 -9.54500  1.000 15.89000  ? 43  ASP A CA   1 
ATOM   632  C C    . ASP A 1 43  ? 20.37700  -29.98900 -10.09900 1.000 16.71000  ? 43  ASP A C    1 
ATOM   633  O O    . ASP A 1 43  ? 20.66500  -30.46500 -11.17400 1.000 17.59000  ? 43  ASP A O    1 
ATOM   634  C CB   . ASP A 1 43  ? 22.27200  -29.36600 -8.57700  1.000 17.07000  ? 43  ASP A CB   1 
ATOM   635  C CG   . ASP A 1 43  ? 23.40000  -28.40500 -8.24200  1.000 23.51000  ? 43  ASP A CG   1 
ATOM   636  O OD1  . ASP A 1 43  ? 23.46000  -27.32600 -8.85200  1.000 25.50000  ? 43  ASP A OD1  1 
ATOM   637  O OD2  . ASP A 1 43  ? 24.20800  -28.75200 -7.37000  1.000 27.42000  ? 43  ASP A OD2  1 
ATOM   638  H H    . ASP A 1 43  ? 20.44200  -27.74800 -7.99700  1.000 18.28000  ? 43  ASP A H    1 
ATOM   639  H HA   . ASP A 1 43  ? 21.68500  -28.41200 -10.30000 1.000 19.09000  ? 43  ASP A HA   1 
ATOM   640  H HB2  . ASP A 1 43  ? 21.82400  -29.61600 -7.74200  1.000 20.50000  ? 43  ASP A HB2  1 
ATOM   641  H HB3  . ASP A 1 43  ? 22.66500  -30.17700 -8.96000  1.000 20.50000  ? 43  ASP A HB3  1 
ATOM   642  N N    . ALA A 1 44  ? 19.37700  -30.41900 -9.34000  1.000 14.67000  ? 44  ALA A N    1 
ATOM   643  C CA   . ALA A 1 44  ? 18.48800  -31.50900 -9.78500  1.000 13.09000  ? 44  ALA A CA   1 
ATOM   644  C C    . ALA A 1 44  ? 17.63100  -31.02500 -10.95700 1.000 15.04000  ? 44  ALA A C    1 
ATOM   645  O O    . ALA A 1 44  ? 17.35500  -31.79900 -11.84600 1.000 14.33000  ? 44  ALA A O    1 
ATOM   646  C CB   . ALA A 1 44  ? 17.63600  -31.98000 -8.63500  1.000 14.92000  ? 44  ALA A CB   1 
ATOM   647  H H    . ALA A 1 44  ? 19.18200  -30.07400 -8.53000  1.000 17.62000  ? 44  ALA A H    1 
ATOM   648  H HA   . ALA A 1 44  ? 19.05300  -32.26700 -10.10200 1.000 15.72000  ? 44  ALA A HA   1 
ATOM   649  H HB1  . ALA A 1 44  ? 17.16800  -32.79500 -8.88700  1.000 17.92000  ? 44  ALA A HB1  1 
ATOM   650  H HB2  . ALA A 1 44  ? 18.20100  -32.15800 -7.86400  1.000 17.92000  ? 44  ALA A HB2  1 
ATOM   651  H HB3  . ALA A 1 44  ? 16.98700  -31.29300 -8.40800  1.000 17.92000  ? 44  ALA A HB3  1 
ATOM   652  N N    . LEU A 1 45  ? 17.24400  -29.75400 -10.95000 1.000 14.78000  ? 45  LEU A N    1 
ATOM   653  C CA   . LEU A 1 45  ? 16.44900  -29.20700 -12.07100 1.000 12.14000  ? 45  LEU A CA   1 
ATOM   654  C C    . LEU A 1 45  ? 17.34700  -29.10700 -13.31100 1.000 15.05000  ? 45  LEU A C    1 
ATOM   655  O O    . LEU A 1 45  ? 16.85700  -29.28400 -14.37700 1.000 15.71000  ? 45  LEU A O    1 
ATOM   656  C CB   . LEU A 1 45  ? 15.86000  -27.85600 -11.68800 1.000 14.40000  ? 45  LEU A CB   1 
ATOM   657  C CG   . LEU A 1 45  ? 14.64500  -27.92200 -10.75700 1.000 14.34000  ? 45  LEU A CG   1 
ATOM   658  C CD1  . LEU A 1 45  ? 14.50900  -26.66100 -9.93500  1.000 15.38000  ? 45  LEU A CD1  1 
ATOM   659  C CD2  . LEU A 1 45  ? 13.38500  -28.16800 -11.55600 1.000 14.93000  ? 45  LEU A CD2  1 
ATOM   660  H H    . LEU A 1 45  ? 17.44200  -29.18100 -10.28200 1.000 17.75000  ? 45  LEU A H    1 
ATOM   661  H HA   . LEU A 1 45  ? 15.70800  -29.83500 -12.26700 1.000 14.59000  ? 45  LEU A HA   1 
ATOM   662  H HB2  . LEU A 1 45  ? 16.56300  -27.32500 -11.24800 1.000 17.30000  ? 45  LEU A HB2  1 
ATOM   663  H HB3  . LEU A 1 45  ? 15.59200  -27.39300 -12.51300 1.000 17.30000  ? 45  LEU A HB3  1 
ATOM   664  H HG   . LEU A 1 45  ? 14.77100  -28.68600 -10.13700 1.000 17.23000  ? 45  LEU A HG   1 
ATOM   665  H HD11 . LEU A 1 45  ? 13.97600  -26.84600 -9.14300  1.000 18.48000  ? 45  LEU A HD11 1 
ATOM   666  H HD12 . LEU A 1 45  ? 15.39000  -26.35100 -9.66600  1.000 18.48000  ? 45  LEU A HD12 1 
ATOM   667  H HD13 . LEU A 1 45  ? 14.07200  -25.97400 -10.46500 1.000 18.48000  ? 45  LEU A HD13 1 
ATOM   668  H HD21 . LEU A 1 45  ? 12.62200  -28.21100 -10.95300 1.000 17.93000  ? 45  LEU A HD21 1 
ATOM   669  H HD22 . LEU A 1 45  ? 13.25500  -27.44200 -12.18900 1.000 17.93000  ? 45  LEU A HD22 1 
ATOM   670  H HD23 . LEU A 1 45  ? 13.46400  -29.00800 -12.03900 1.000 17.93000  ? 45  LEU A HD23 1 
ATOM   671  N N    . ASP A 1 46  ? 18.61000  -28.77600 -13.11100 1.000 15.60000  ? 46  ASP A N    1 
ATOM   672  C CA   . ASP A 1 46  ? 19.56200  -28.70800 -14.24300 1.000 15.43000  ? 46  ASP A CA   1 
ATOM   673  C C    . ASP A 1 46  ? 19.63400  -30.08500 -14.89000 1.000 18.38000  ? 46  ASP A C    1 
ATOM   674  O O    . ASP A 1 46  ? 19.79900  -30.13400 -16.07300 1.000 17.48000  ? 46  ASP A O    1 
ATOM   675  C CB   . ASP A 1 46  ? 20.96700  -28.34100 -13.80700 1.000 14.25000  ? 46  ASP A CB   1 
ATOM   676  C CG   . ASP A 1 46  ? 21.27000  -26.90400 -13.42500 1.000 16.69000  ? 46  ASP A CG   1 
ATOM   677  O OD1  . ASP A 1 46  ? 20.53900  -26.03100 -13.81000 1.000 18.10000  ? 46  ASP A OD1  1 
ATOM   678  O OD2  . ASP A 1 46  ? 22.27900  -26.66700 -12.77900 1.000 21.37000  ? 46  ASP A OD2  1 
ATOM   679  H H    . ASP A 1 46  ? 18.93300  -28.60300 -12.28800 1.000 18.74000  ? 46  ASP A H    1 
ATOM   680  H HA   . ASP A 1 46  ? 19.23000  -28.05900 -14.90300 1.000 18.53000  ? 46  ASP A HA   1 
ATOM   681  H HB2  . ASP A 1 46  ? 21.20900  -28.89500 -13.04200 1.000 17.12000  ? 46  ASP A HB2  1 
ATOM   682  H HB3  . ASP A 1 46  ? 21.57400  -28.58000 -14.53700 1.000 17.12000  ? 46  ASP A HB3  1 
ATOM   683  N N    . LYS A 1 47  ? 19.59900  -31.14300 -14.10100 1.000 16.49000  ? 47  LYS A N    1 
ATOM   684  C CA   . LYS A 1 47  ? 19.76600  -32.51200 -14.63700 1.000 16.35000  ? 47  LYS A CA   1 
ATOM   685  C C    . LYS A 1 47  ? 18.52800  -32.93700 -15.43300 1.000 19.57000  ? 47  LYS A C    1 
ATOM   686  O O    . LYS A 1 47  ? 18.73200  -33.54800 -16.46100 1.000 16.87000  ? 47  LYS A O    1 
ATOM   687  C CB   . LYS A 1 47  ? 20.10000  -33.49000 -13.51000 1.000 17.64000  ? 47  LYS A CB   1 
ATOM   688  C CG   . LYS A 1 47  ? 21.47200  -33.29800 -12.92600 1.000 20.82000  ? 47  LYS A CG   1 
ATOM   689  C CD   . LYS A 1 47  ? 21.62100  -34.03000 -11.60500 1.000 29.64000  ? 47  LYS A CD   1 
ATOM   690  C CE   . LYS A 1 47  ? 23.00500  -34.51900 -11.38800 1.000 48.34000  ? 47  LYS A CE   1 
ATOM   691  N NZ   . LYS A 1 47  ? 23.96000  -33.41400 -11.44300 1.000 44.12000  ? 47  LYS A NZ   1 
ATOM   692  H H    . LYS A 1 47  ? 19.47900  -31.06800 -13.21000 1.000 19.80000  ? 47  LYS A H    1 
ATOM   693  H HA   . LYS A 1 47  ? 20.53900  -32.50400 -15.25500 1.000 19.64000  ? 47  LYS A HA   1 
ATOM   694  H HB2  . LYS A 1 47  ? 19.43900  -33.38400 -12.79300 1.000 21.19000  ? 47  LYS A HB2  1 
ATOM   695  H HB3  . LYS A 1 47  ? 20.02800  -34.40600 -13.85100 1.000 21.19000  ? 47  LYS A HB3  1 
ATOM   696  H HG2  . LYS A 1 47  ? 22.13800  -33.63400 -13.56200 1.000 25.00000  ? 47  LYS A HG2  1 
ATOM   697  H HG3  . LYS A 1 47  ? 21.63100  -32.34000 -12.78800 1.000 25.00000  ? 47  LYS A HG3  1 
ATOM   698  H HD2  . LYS A 1 47  ? 21.37500  -33.42300 -10.87200 1.000 35.58000  ? 47  LYS A HD2  1 
ATOM   699  H HD3  . LYS A 1 47  ? 21.00200  -34.79200 -11.59100 1.000 35.58000  ? 47  LYS A HD3  1 
ATOM   700  H HE2  . LYS A 1 47  ? 23.06300  -34.95000 -10.51700 1.000 58.02000  ? 47  LYS A HE2  1 
ATOM   701  H HE3  . LYS A 1 47  ? 23.23100  -35.17200 -12.07400 1.000 58.02000  ? 47  LYS A HE3  1 
ATOM   702  H HZ1  . LYS A 1 47  ? 24.69900  -33.62400 -10.96400 1.000 52.96000  ? 47  LYS A HZ1  1 
ATOM   703  H HZ2  . LYS A 1 47  ? 24.19900  -33.25000 -12.30100 1.000 52.96000  ? 47  LYS A HZ2  1 
ATOM   704  H HZ3  . LYS A 1 47  ? 23.58100  -32.67000 -11.09000 1.000 52.96000  ? 47  LYS A HZ3  1 
ATOM   705  N N    . ILE A 1 48  ? 17.30800  -32.65900 -14.98100 1.000 16.68000  ? 48  ILE A N    1 
ATOM   706  C CA   . ILE A 1 48  ? 16.17500  -33.02100 -15.82300 1.000 16.00000  ? 48  ILE A CA   1 
ATOM   707  C C    . ILE A 1 48  ? 16.11900  -32.13300 -17.05600 1.000 18.17000  ? 48  ILE A C    1 
ATOM   708  O O    . ILE A 1 48  ? 15.67000  -32.60600 -18.11000 1.000 18.83000  ? 48  ILE A O    1 
ATOM   709  C CB   . ILE A 1 48  ? 14.83900  -33.00600 -14.99700 1.000 17.19000  ? 48  ILE A CB   1 
ATOM   710  C CG1  . ILE A 1 48  ? 13.71500  -33.66300 -15.76000 1.000 19.87000  ? 48  ILE A CG1  1 
ATOM   711  C CG2  . ILE A 1 48  ? 14.41900  -31.62500 -14.58800 1.000 18.59000  ? 48  ILE A CG2  1 
ATOM   712  C CD1  . ILE A 1 48  ? 13.92300  -35.08100 -16.04700 1.000 21.17000  ? 48  ILE A CD1  1 
ATOM   713  H H    . ILE A 1 48  ? 17.11800  -32.29400 -14.22600 1.000 20.03000  ? 48  ILE A H    1 
ATOM   714  H HA   . ILE A 1 48  ? 16.29600  -33.93200 -16.13300 1.000 19.22000  ? 48  ILE A HA   1 
ATOM   715  H HB   . ILE A 1 48  ? 15.02600  -33.51300 -14.19100 1.000 20.64000  ? 48  ILE A HB   1 
ATOM   716  H HG12 . ILE A 1 48  ? 12.90100  -33.58700 -15.23800 1.000 23.86000  ? 48  ILE A HG12 1 
ATOM   717  H HG13 . ILE A 1 48  ? 13.60900  -33.20600 -16.60900 1.000 23.86000  ? 48  ILE A HG13 1 
ATOM   718  H HG21 . ILE A 1 48  ? 13.60400  -31.68400 -14.06600 1.000 22.33000  ? 48  ILE A HG21 1 
ATOM   719  H HG22 . ILE A 1 48  ? 15.12500  -31.22600 -14.05500 1.000 22.33000  ? 48  ILE A HG22 1 
ATOM   720  H HG23 . ILE A 1 48  ? 14.26500  -31.09300 -15.38400 1.000 22.33000  ? 48  ILE A HG23 1 
ATOM   721  H HD11 . ILE A 1 48  ? 13.06300  -35.50200 -16.19900 1.000 25.42000  ? 48  ILE A HD11 1 
ATOM   722  H HD12 . ILE A 1 48  ? 14.47700  -35.16500 -16.83800 1.000 25.42000  ? 48  ILE A HD12 1 
ATOM   723  H HD13 . ILE A 1 48  ? 14.36400  -35.49500 -15.28900 1.000 25.42000  ? 48  ILE A HD13 1 
ATOM   724  N N    . ARG A 1 49  ? 16.50800  -30.85100 -16.95600 1.000 16.79000  ? 49  ARG A N    1 
ATOM   725  C CA   . ARG A 1 49  ? 16.52300  -30.00300 -18.14500 1.000 19.48000  ? 49  ARG A CA   1 
ATOM   726  C C    . ARG A 1 49  ? 17.49100  -30.56600 -19.16100 1.000 21.31000  ? 49  ARG A C    1 
ATOM   727  O O    . ARG A 1 49  ? 17.19600  -30.59400 -20.36500 1.000 22.07000  ? 49  ARG A O    1 
ATOM   728  C CB   . ARG A 1 49  ? 16.90300  -28.57600 -17.76200 1.000 20.81000  ? 49  ARG A CB   1 
ATOM   729  C CG   . ARG A 1 49  ? 16.75500  -27.57300 -18.84800 1.000 30.58000  ? 49  ARG A CG   1 
ATOM   730  C CD   . ARG A 1 49  ? 16.55500  -26.19200 -18.17400 1.000 25.12000  ? 49  ARG A CD   1 
ATOM   731  N NE   . ARG A 1 49  ? 17.67000  -25.84300 -17.30100 1.000 28.42000  ? 49  ARG A NE   1 
ATOM   732  C CZ   . ARG A 1 49  ? 18.83900  -25.40300 -17.73600 1.000 29.21000  ? 49  ARG A CZ   1 
ATOM   733  N NH1  . ARG A 1 49  ? 19.08200  -25.26300 -19.03200 1.000 38.71000  ? 49  ARG A NH1  1 
ATOM   734  N NH2  . ARG A 1 49  ? 19.79500  -25.09600 -16.85100 1.000 30.82000  ? 49  ARG A NH2  1 
ATOM   735  H H    . ARG A 1 49  ? 16.76000  -30.46400 -16.23000 1.000 20.16000  ? 49  ARG A H    1 
ATOM   736  H HA   . ARG A 1 49  ? 15.63800  -29.97000 -18.54000 1.000 23.39000  ? 49  ARG A HA   1 
ATOM   737  H HB2  . ARG A 1 49  ? 16.33700  -28.29400 -17.02700 1.000 25.00000  ? 49  ARG A HB2  1 
ATOM   738  H HB3  . ARG A 1 49  ? 17.83300  -28.57000 -17.48600 1.000 25.00000  ? 49  ARG A HB3  1 
ATOM   739  H HG2  . ARG A 1 49  ? 17.55400  -27.55100 -19.39800 1.000 36.71000  ? 49  ARG A HG2  1 
ATOM   740  H HG3  . ARG A 1 49  ? 15.98100  -27.77900 -19.39500 1.000 36.71000  ? 49  ARG A HG3  1 
ATOM   741  H HD2  . ARG A 1 49  ? 16.48200  -25.51000 -18.85900 1.000 30.16000  ? 49  ARG A HD2  1 
ATOM   742  H HD3  . ARG A 1 49  ? 15.74700  -26.21300 -17.63800 1.000 30.16000  ? 49  ARG A HD3  1 
ATOM   743  H HE   . ARG A 1 49  ? 17.56100  -25.92900 -16.45200 1.000 34.13000  ? 49  ARG A HE   1 
ATOM   744  H HH11 . ARG A 1 49  ? 18.47400  -25.46000 -19.60800 1.000 46.47000  ? 49  ARG A HH11 1 
ATOM   745  H HH12 . ARG A 1 49  ? 19.84800  -24.97500 -19.29800 1.000 46.47000  ? 49  ARG A HH12 1 
ATOM   746  H HH21 . ARG A 1 49  ? 19.64700  -25.18600 -16.00900 1.000 37.00000  ? 49  ARG A HH21 1 
ATOM   747  H HH22 . ARG A 1 49  ? 20.55800  -24.80900 -17.12600 1.000 37.00000  ? 49  ARG A HH22 1 
ATOM   748  N N    . TYR A 1 50  ? 18.64700  -31.01200 -18.70800 1.000 18.73000  ? 50  TYR A N    1 
ATOM   749  C CA   . TYR A 1 50  ? 19.62800  -31.59900 -19.62100 1.000 19.22000  ? 50  TYR A CA   1 
ATOM   750  C C    . TYR A 1 50  ? 19.02100  -32.79900 -20.34200 1.000 21.47000  ? 50  TYR A C    1 
ATOM   751  O O    . TYR A 1 50  ? 19.12000  -32.94800 -21.58700 1.000 21.23000  ? 50  TYR A O    1 
ATOM   752  C CB   . TYR A 1 50  ? 20.89100  -32.02700 -18.84600 1.000 19.96000  ? 50  TYR A CB   1 
ATOM   753  C CG   . TYR A 1 50  ? 21.99800  -32.61800 -19.70800 1.000 20.91000  ? 50  TYR A CG   1 
ATOM   754  C CD1  . TYR A 1 50  ? 21.98600  -33.92400 -20.04600 1.000 24.38000  ? 50  TYR A CD1  1 
ATOM   755  C CD2  . TYR A 1 50  ? 22.99900  -31.80200 -20.17900 1.000 26.62000  ? 50  TYR A CD2  1 
ATOM   756  C CE1  . TYR A 1 50  ? 22.98300  -34.47400 -20.84600 1.000 26.40000  ? 50  TYR A CE1  1 
ATOM   757  C CE2  . TYR A 1 50  ? 23.99100  -32.34000 -20.99300 1.000 27.16000  ? 50  TYR A CE2  1 
ATOM   758  C CZ   . TYR A 1 50  ? 23.96900  -33.64900 -21.30800 1.000 28.70000  ? 50  TYR A CZ   1 
ATOM   759  O OH   . TYR A 1 50  ? 24.96800  -34.18400 -22.13400 1.000 28.68000  ? 50  TYR A OH   1 
ATOM   760  H H    . TYR A 1 50  ? 18.89400  -30.99000 -17.88400 1.000 22.49000  ? 50  TYR A H    1 
ATOM   761  H HA   . TYR A 1 50  ? 19.89000  -30.93300 -20.27600 1.000 23.09000  ? 50  TYR A HA   1 
ATOM   762  H HB2  . TYR A 1 50  ? 21.25600  -31.24800 -18.39700 1.000 23.97000  ? 50  TYR A HB2  1 
ATOM   763  H HB3  . TYR A 1 50  ? 20.64000  -32.69900 -18.19300 1.000 23.97000  ? 50  TYR A HB3  1 
ATOM   764  H HD1  . TYR A 1 50  ? 21.29800  -34.46800 -19.73800 1.000 29.28000  ? 50  TYR A HD1  1 
ATOM   765  H HD2  . TYR A 1 50  ? 23.01300  -30.89900 -19.95600 1.000 31.96000  ? 50  TYR A HD2  1 
ATOM   766  H HE1  . TYR A 1 50  ? 22.97800  -35.37900 -21.06100 1.000 31.70000  ? 50  TYR A HE1  1 
ATOM   767  H HE2  . TYR A 1 50  ? 24.67000  -31.79500 -21.31900 1.000 32.61000  ? 50  TYR A HE2  1 
ATOM   768  H HH   . TYR A 1 50  ? 25.48400  -33.57400 -22.39300 1.000 34.43000  ? 50  TYR A HH   1 
ATOM   769  N N    . GLN A 1 51  ? 18.39100  -33.68200 -19.58600 1.000 19.35000  ? 51  GLN A N    1 
ATOM   770  C CA   . GLN A 1 51  ? 17.78800  -34.86800 -20.20700 1.000 20.87000  ? 51  GLN A CA   1 
ATOM   771  C C    . GLN A 1 51  ? 16.68000  -34.49600 -21.15200 1.000 26.89000  ? 51  GLN A C    1 
ATOM   772  O O    . GLN A 1 51  ? 16.52000  -35.12800 -22.20800 1.000 26.23000  ? 51  GLN A O    1 
ATOM   773  C CB   . GLN A 1 51  ? 17.28100  -35.84600 -19.12400 1.000 20.99000  ? 51  GLN A CB   1 
ATOM   774  C CG   . GLN A 1 51  ? 18.36000  -36.55000 -18.41700 1.000 19.58000  ? 51  GLN A CG   1 
ATOM   775  C CD   . GLN A 1 51  ? 17.93200  -37.82600 -17.66300 1.000 20.43000  ? 51  GLN A CD   1 
ATOM   776  O OE1  . GLN A 1 51  ? 16.72700  -38.18000 -17.66300 1.000 26.10000  ? 51  GLN A OE1  1 
ATOM   777  N NE2  . GLN A 1 51  ? 18.84400  -38.45500 -17.08100 1.000 23.90000  ? 51  GLN A NE2  1 
ATOM   778  H H    . GLN A 1 51  ? 18.29500  -33.62800 -18.73300 1.000 23.24000  ? 51  GLN A H    1 
ATOM   779  H HA   . GLN A 1 51  ? 18.47300  -35.32600 -20.72000 1.000 25.07000  ? 51  GLN A HA   1 
ATOM   780  H HB2  . GLN A 1 51  ? 16.77100  -35.34700 -18.46600 1.000 25.20000  ? 51  GLN A HB2  1 
ATOM   781  H HB3  . GLN A 1 51  ? 16.71700  -36.51300 -19.54500 1.000 25.20000  ? 51  GLN A HB3  1 
ATOM   782  H HG2  . GLN A 1 51  ? 19.03300  -36.80900 -19.06600 1.000 23.52000  ? 51  GLN A HG2  1 
ATOM   783  H HG3  . GLN A 1 51  ? 18.74500  -35.94400 -17.76400 1.000 23.52000  ? 51  GLN A HG3  1 
ATOM   784  H HE21 . GLN A 1 51  ? 19.65400  -38.16900 -17.11600 1.000 28.70000  ? 51  GLN A HE21 1 
ATOM   785  H HE22 . GLN A 1 51  ? 18.66000  -39.17400 -16.64500 1.000 28.70000  ? 51  GLN A HE22 1 
ATOM   786  N N    . ALA A 1 52  ? 15.86600  -33.52000 -20.78500 1.000 19.73000  ? 52  ALA A N    1 
ATOM   787  C CA   . ALA A 1 52  ? 14.75400  -33.10900 -21.60000 1.000 19.99000  ? 52  ALA A CA   1 
ATOM   788  C C    . ALA A 1 52  ? 15.18600  -32.40000 -22.88600 1.000 25.23000  ? 52  ALA A C    1 
ATOM   789  O O    . ALA A 1 52  ? 14.36200  -32.29600 -23.81800 1.000 29.58000  ? 52  ALA A O    1 
ATOM   790  C CB   . ALA A 1 52  ? 13.84200  -32.17400 -20.81700 1.000 24.33000  ? 52  ALA A CB   1 
ATOM   791  H H    . ALA A 1 52  ? 15.94200  -33.07500 -20.05400 1.000 23.70000  ? 52  ALA A H    1 
ATOM   792  H HA   . ALA A 1 52  ? 14.25800  -33.90800 -21.84000 1.000 24.01000  ? 52  ALA A HA   1 
ATOM   793  H HB1  . ALA A 1 52  ? 13.08000  -31.94000 -21.37000 1.000 29.21000  ? 52  ALA A HB1  1 
ATOM   794  H HB2  . ALA A 1 52  ? 13.54100  -32.62600 -20.01300 1.000 29.21000  ? 52  ALA A HB2  1 
ATOM   795  H HB3  . ALA A 1 52  ? 14.33700  -31.37400 -20.58100 1.000 29.21000  ? 52  ALA A HB3  1 
ATOM   796  N N    . LEU A 1 53  ? 16.39100  -31.80700 -22.91900 1.000 21.33000  ? 53  LEU A N    1 
ATOM   797  C CA   . LEU A 1 53  ? 16.81200  -31.16000 -24.14500 1.000 31.39000  ? 53  LEU A CA   1 
ATOM   798  C C    . LEU A 1 53  ? 16.92500  -32.20300 -25.23500 1.000 29.09000  ? 53  LEU A C    1 
ATOM   799  O O    . LEU A 1 53  ? 16.53300  -31.95100 -26.38700 1.000 36.74000  ? 53  LEU A O    1 
ATOM   800  C CB   . LEU A 1 53  ? 18.13300  -30.44200 -23.94400 1.000 26.99000  ? 53  LEU A CB   1 
ATOM   801  C CG   . LEU A 1 53  ? 18.64200  -29.58000 -25.10100 1.000 41.72000  ? 53  LEU A CG   1 
ATOM   802  C CD1  . LEU A 1 53  ? 17.63800  -28.49600 -25.43600 1.000 45.73000  ? 53  LEU A CD1  1 
ATOM   803  C CD2  . LEU A 1 53  ? 19.98400  -28.97600 -24.75900 1.000 38.59000  ? 53  LEU A CD2  1 
ATOM   804  H H    . LEU A 1 53  ? 16.95100  -31.77200 -22.26700 1.000 25.62000  ? 53  LEU A H    1 
ATOM   805  H HA   . LEU A 1 53  ? 16.16600  -30.48500 -24.40600 1.000 37.68000  ? 53  LEU A HA   1 
ATOM   806  H HB2  . LEU A 1 53  ? 18.04000  -29.85800 -23.17600 1.000 32.41000  ? 53  LEU A HB2  1 
ATOM   807  H HB3  . LEU A 1 53  ? 18.81200  -31.11200 -23.77100 1.000 32.41000  ? 53  LEU A HB3  1 
ATOM   808  H HG   . LEU A 1 53  ? 18.75400  -30.13700 -25.88700 1.000 50.08000  ? 53  LEU A HG   1 
ATOM   809  H HD11 . LEU A 1 53  ? 17.99000  -27.95100 -26.15800 1.000 54.89000  ? 53  LEU A HD11 1 
ATOM   810  H HD12 . LEU A 1 53  ? 16.80500  -28.91100 -25.71100 1.000 54.89000  ? 53  LEU A HD12 1 
ATOM   811  H HD13 . LEU A 1 53  ? 17.49100  -27.94800 -24.65000 1.000 54.89000  ? 53  LEU A HD13 1 
ATOM   812  H HD21 . LEU A 1 53  ? 20.28300  -28.43000 -25.50300 1.000 46.33000  ? 53  LEU A HD21 1 
ATOM   813  H HD22 . LEU A 1 53  ? 19.89000  -28.42900 -23.96300 1.000 46.33000  ? 53  LEU A HD22 1 
ATOM   814  H HD23 . LEU A 1 53  ? 20.61900  -29.69100 -24.59700 1.000 46.33000  ? 53  LEU A HD23 1 
ATOM   815  N N    . SER A 1 54  ? 17.45700  -33.37300 -24.89000 1.000 26.89000  ? 54  SER A N    1 
ATOM   816  C CA   . SER A 1 54  ? 17.51200  -34.46100 -25.86400 1.000 27.96000  ? 54  SER A CA   1 
ATOM   817  C C    . SER A 1 54  ? 16.16300  -35.14500 -26.02200 1.000 39.59000  ? 54  SER A C    1 
ATOM   818  O O    . SER A 1 54  ? 15.76200  -35.46900 -27.13600 1.000 42.32000  ? 54  SER A O    1 
ATOM   819  C CB   . SER A 1 54  ? 18.50800  -35.50300 -25.42200 1.000 30.21000  ? 54  SER A CB   1 
ATOM   820  O OG   . SER A 1 54  ? 19.81300  -34.99200 -25.48100 1.000 51.23000  ? 54  SER A OG   1 
ATOM   821  H H    . SER A 1 54  ? 17.78700  -33.55900 -24.11800 1.000 32.29000  ? 54  SER A H    1 
ATOM   822  H HA   . SER A 1 54  ? 17.78500  -34.08200 -26.71400 1.000 33.57000  ? 54  SER A HA   1 
ATOM   823  H HB2  . SER A 1 54  ? 18.31100  -35.76300 -24.50900 1.000 36.28000  ? 54  SER A HB2  1 
ATOM   824  H HB3  . SER A 1 54  ? 18.44300  -36.27300 -26.00800 1.000 36.28000  ? 54  SER A HB3  1 
ATOM   825  H HG   . SER A 1 54  ? 20.36700  -35.59700 -25.30000 1.000 61.49000  ? 54  SER A HG   1 
ATOM   826  N N    . ASP A 1 55  ? 15.47300  -35.41700 -24.91200 1.000 24.55000  ? 55  ASP A N    1 
ATOM   827  C CA   . ASP A 1 55  ? 14.22400  -36.16800 -24.90400 1.000 25.00000  ? 55  ASP A CA   1 
ATOM   828  C C    . ASP A 1 55  ? 13.14300  -35.42500 -24.14600 1.000 24.02000  ? 55  ASP A C    1 
ATOM   829  O O    . ASP A 1 55  ? 12.99900  -35.59800 -22.91700 1.000 23.45000  ? 55  ASP A O    1 
ATOM   830  C CB   . ASP A 1 55  ? 14.42600  -37.55200 -24.28500 1.000 23.74000  ? 55  ASP A CB   1 
ATOM   831  C CG   . ASP A 1 55  ? 13.08000  -38.37000 -24.19700 1.000 20.36000  ? 55  ASP A CG   1 
ATOM   832  O OD1  . ASP A 1 55  ? 12.01500  -37.89700 -24.63600 1.000 25.65000  ? 55  ASP A OD1  1 
ATOM   833  O OD2  . ASP A 1 55  ? 13.11700  -39.48600 -23.62400 1.000 27.74000  ? 55  ASP A OD2  1 
ATOM   834  H H    . ASP A 1 55  ? 15.72000  -35.16800 -24.12700 1.000 29.48000  ? 55  ASP A H    1 
ATOM   835  H HA   . ASP A 1 55  ? 13.93000  -36.24400 -25.82500 1.000 30.02000  ? 55  ASP A HA   1 
ATOM   836  H HB2  . ASP A 1 55  ? 15.05100  -38.05600 -24.83000 1.000 28.50000  ? 55  ASP A HB2  1 
ATOM   837  H HB3  . ASP A 1 55  ? 14.77700  -37.45100 -23.38700 1.000 28.50000  ? 55  ASP A HB3  1 
ATOM   838  N N    . PRO A 1 56  ? 12.38500  -34.57200 -24.81400 1.000 27.71000  ? 56  PRO A N    1 
ATOM   839  C CA   . PRO A 1 56  ? 11.40700  -33.75200 -24.10000 1.000 24.47000  ? 56  PRO A CA   1 
ATOM   840  C C    . PRO A 1 56  ? 10.35800  -34.54100 -23.32100 1.000 25.79000  ? 56  PRO A C    1 
ATOM   841  O O    . PRO A 1 56  ? 9.74800   -33.98100 -22.38300 1.000 27.83000  ? 56  PRO A O    1 
ATOM   842  C CB   . PRO A 1 56  ? 10.75100  -32.91700 -25.21900 1.000 31.34000  ? 56  PRO A CB   1 
ATOM   843  C CG   . PRO A 1 56  ? 11.86400  -32.81000 -26.25600 1.000 31.50000  ? 56  PRO A CG   1 
ATOM   844  C CD   . PRO A 1 56  ? 12.49800  -34.17300 -26.25100 1.000 24.93000  ? 56  PRO A CD   1 
ATOM   845  H HA   . PRO A 1 56  ? 11.87700  -33.16600 -23.48700 1.000 29.39000  ? 56  PRO A HA   1 
ATOM   846  H HB2  . PRO A 1 56  ? 9.97600   -33.37800 -25.57600 1.000 37.63000  ? 56  PRO A HB2  1 
ATOM   847  H HB3  . PRO A 1 56  ? 10.49200  -32.04400 -24.88400 1.000 37.63000  ? 56  PRO A HB3  1 
ATOM   848  H HG2  . PRO A 1 56  ? 11.49200  -32.60000 -27.12700 1.000 37.82000  ? 56  PRO A HG2  1 
ATOM   849  H HG3  . PRO A 1 56  ? 12.50100  -32.12600 -25.99400 1.000 37.82000  ? 56  PRO A HG3  1 
ATOM   850  H HD2  . PRO A 1 56  ? 12.01100  -34.78700 -26.82300 1.000 29.94000  ? 56  PRO A HD2  1 
ATOM   851  H HD3  . PRO A 1 56  ? 13.42700  -34.12800 -26.52800 1.000 29.94000  ? 56  PRO A HD3  1 
ATOM   852  N N    . SER A 1 57  ? 10.15300  -35.82400 -23.64900 1.000 25.07000  ? 57  SER A N    1 
ATOM   853  C CA   . SER A 1 57  ? 9.13700   -36.61400 -22.95000 1.000 24.63000  ? 57  SER A CA   1 
ATOM   854  C C    . SER A 1 57  ? 9.46000   -36.79600 -21.47300 1.000 23.59000  ? 57  SER A C    1 
ATOM   855  O O    . SER A 1 57  ? 8.55600   -37.11400 -20.68600 1.000 21.28000  ? 57  SER A O    1 
ATOM   856  C CB   . SER A 1 57  ? 8.92200   -37.96200 -23.61100 1.000 20.45000  ? 57  SER A CB   1 
ATOM   857  O OG   . SER A 1 57  ? 9.92700   -38.87300 -23.31200 1.000 25.95000  ? 57  SER A OG   1 
ATOM   858  H H    . SER A 1 57  ? 10.58100  -36.25000 -24.26100 1.000 30.10000  ? 57  SER A H    1 
ATOM   859  H HA   . SER A 1 57  ? 8.29700   -36.13600 -23.01900 1.000 29.58000  ? 57  SER A HA   1 
ATOM   860  H HB2  . SER A 1 57  ? 8.07600   -38.32400 -23.30300 1.000 24.56000  ? 57  SER A HB2  1 
ATOM   861  H HB3  . SER A 1 57  ? 8.89800   -37.83400 -24.57200 1.000 24.56000  ? 57  SER A HB3  1 
ATOM   862  H HG   . SER A 1 57  ? 9.78800   -39.59700 -23.71300 1.000 31.16000  ? 57  SER A HG   1 
ATOM   863  N N    . GLN A 1 58  ? 10.70900  -36.60000 -21.09600 1.000 20.78000  ? 58  GLN A N    1 
ATOM   864  C CA   . GLN A 1 58  ? 11.11300  -36.73900 -19.69200 1.000 20.89000  ? 58  GLN A CA   1 
ATOM   865  C C    . GLN A 1 58  ? 10.43200  -35.72900 -18.80800 1.000 23.22000  ? 58  GLN A C    1 
ATOM   866  O O    . GLN A 1 58  ? 10.41900  -35.94400 -17.58900 1.000 21.58000  ? 58  GLN A O    1 
ATOM   867  C CB   . GLN A 1 58  ? 12.63000  -36.56200 -19.49100 1.000 19.83000  ? 58  GLN A CB   1 
ATOM   868  C CG   . GLN A 1 58  ? 13.46800  -37.67200 -20.22100 1.000 21.22000  ? 58  GLN A CG   1 
ATOM   869  C CD   . GLN A 1 58  ? 13.01400  -39.03900 -19.79000 1.000 24.81000  ? 58  GLN A CD   1 
ATOM   870  O OE1  . GLN A 1 58  ? 12.99000  -39.35900 -18.58000 1.000 28.19000  ? 58  GLN A OE1  1 
ATOM   871  N NE2  . GLN A 1 58  ? 12.69200  -39.88300 -20.74400 1.000 30.48000  ? 58  GLN A NE2  1 
ATOM   872  H H    . GLN A 1 58  ? 11.35100  -36.38500 -21.62600 1.000 24.95000  ? 58  GLN A H    1 
ATOM   873  H HA   . GLN A 1 58  ? 10.87600  -37.64300 -19.43200 1.000 25.09000  ? 58  GLN A HA   1 
ATOM   874  H HB2  . GLN A 1 58  ? 12.89700  -35.70000 -19.84600 1.000 23.81000  ? 58  GLN A HB2  1 
ATOM   875  H HB3  . GLN A 1 58  ? 12.83100  -36.60700 -18.54300 1.000 23.81000  ? 58  GLN A HB3  1 
ATOM   876  H HG2  . GLN A 1 58  ? 13.34700  -37.59300 -21.18000 1.000 25.49000  ? 58  GLN A HG2  1 
ATOM   877  H HG3  . GLN A 1 58  ? 14.40700  -37.57100 -19.99500 1.000 25.49000  ? 58  GLN A HG3  1 
ATOM   878  H HE21 . GLN A 1 58  ? 12.74700  -39.64200 -21.56800 1.000 36.60000  ? 58  GLN A HE21 1 
ATOM   879  H HE22 . GLN A 1 58  ? 12.42700  -40.67700 -20.54500 1.000 36.60000  ? 58  GLN A HE22 1 
ATOM   880  N N    . LEU A 1 59  ? 9.95300   -34.61600 -19.36400 1.000 21.30000  ? 59  LEU A N    1 
ATOM   881  C CA   . LEU A 1 59  ? 9.28600   -33.63300 -18.54700 1.000 19.22000  ? 59  LEU A CA   1 
ATOM   882  C C    . LEU A 1 59  ? 7.81500   -33.96400 -18.31600 1.000 23.37000  ? 59  LEU A C    1 
ATOM   883  O O    . LEU A 1 59  ? 7.18000   -33.32300 -17.46300 1.000 24.92000  ? 59  LEU A O    1 
ATOM   884  C CB   . LEU A 1 59  ? 9.38600   -32.24500 -19.20300 1.000 21.33000  ? 59  LEU A CB   1 
ATOM   885  C CG   . LEU A 1 59  ? 10.73400  -31.61600 -19.20700 1.000 29.72000  ? 59  LEU A CG   1 
ATOM   886  C CD1  . LEU A 1 59  ? 10.73000  -30.31500 -20.00500 1.000 34.47000  ? 59  LEU A CD1  1 
ATOM   887  C CD2  . LEU A 1 59  ? 11.21000  -31.42500 -17.74300 1.000 29.29000  ? 59  LEU A CD2  1 
ATOM   888  H H    . LEU A 1 59  ? 10.00600  -34.41900 -20.19900 1.000 25.58000  ? 59  LEU A H    1 
ATOM   889  H HA   . LEU A 1 59  ? 9.73100   -33.59500 -17.68600 1.000 23.08000  ? 59  LEU A HA   1 
ATOM   890  H HB2  . LEU A 1 59  ? 9.10600   -32.32800 -20.12800 1.000 25.62000  ? 59  LEU A HB2  1 
ATOM   891  H HB3  . LEU A 1 59  ? 8.79100   -31.64400 -18.72800 1.000 25.62000  ? 59  LEU A HB3  1 
ATOM   892  H HG   . LEU A 1 59  ? 11.37600  -32.19200 -19.65200 1.000 35.69000  ? 59  LEU A HG   1 
ATOM   893  H HD11 . LEU A 1 59  ? 11.64100  -29.99700 -20.09600 1.000 41.39000  ? 59  LEU A HD11 1 
ATOM   894  H HD12 . LEU A 1 59  ? 10.34900  -30.48300 -20.88100 1.000 41.39000  ? 59  LEU A HD12 1 
ATOM   895  H HD13 . LEU A 1 59  ? 10.19500  -29.65700 -19.53300 1.000 41.39000  ? 59  LEU A HD13 1 
ATOM   896  H HD21 . LEU A 1 59  ? 11.96900  -30.82100 -17.73400 1.000 35.17000  ? 59  LEU A HD21 1 
ATOM   897  H HD22 . LEU A 1 59  ? 10.48300  -31.05200 -17.22100 1.000 35.17000  ? 59  LEU A HD22 1 
ATOM   898  H HD23 . LEU A 1 59  ? 11.47000  -32.28700 -17.38100 1.000 35.17000  ? 59  LEU A HD23 1 
ATOM   899  N N    . GLU A 1 60  ? 7.23100   -34.93800 -19.04900 1.000 22.88000  ? 60  GLU A N    1 
ATOM   900  C CA   . GLU A 1 60  ? 5.77400   -35.13700 -18.99900 1.000 22.26000  ? 60  GLU A CA   1 
ATOM   901  C C    . GLU A 1 60  ? 5.26000   -35.51300 -17.60200 1.000 23.39000  ? 60  GLU A C    1 
ATOM   902  O O    . GLU A 1 60  ? 4.10000   -35.23800 -17.26600 1.000 23.71000  ? 60  GLU A O    1 
ATOM   903  C CB   . GLU A 1 60  ? 5.35100   -36.24100 -20.00200 1.000 24.24000  ? 60  GLU A CB   1 
ATOM   904  C CG   . GLU A 1 60  ? 5.61900   -35.80600 -21.43400 1.000 29.69000  ? 60  GLU A CG   1 
ATOM   905  C CD   . GLU A 1 60  ? 5.31500   -36.87700 -22.48100 1.000 29.96000  ? 60  GLU A CD   1 
ATOM   906  O OE1  . GLU A 1 60  ? 4.83000   -37.98000 -22.14000 1.000 35.82000  ? 60  GLU A OE1  1 
ATOM   907  O OE2  . GLU A 1 60  ? 5.58400   -36.58100 -23.66300 1.000 37.15000  ? 60  GLU A OE2  1 
ATOM   908  H H    . GLU A 1 60  ? 7.64900   -35.48000 -19.56900 1.000 27.47000  ? 60  GLU A H    1 
ATOM   909  H HA   . GLU A 1 60  ? 5.36300   -34.29500 -19.25000 1.000 26.74000  ? 60  GLU A HA   1 
ATOM   910  H HB2  . GLU A 1 60  ? 5.85800   -37.04900 -19.82500 1.000 29.11000  ? 60  GLU A HB2  1 
ATOM   911  H HB3  . GLU A 1 60  ? 4.40200   -36.41800 -19.90600 1.000 29.11000  ? 60  GLU A HB3  1 
ATOM   912  H HG2  . GLU A 1 60  ? 5.06500   -35.03500 -21.63300 1.000 35.64000  ? 60  GLU A HG2  1 
ATOM   913  H HG3  . GLU A 1 60  ? 6.55700   -35.57100 -21.51700 1.000 35.64000  ? 60  GLU A HG3  1 
ATOM   914  N N    . SER A 1 61  ? 6.11800   -36.10900 -16.77400 1.000 22.42000  ? 61  SER A N    1 
ATOM   915  C CA   . SER A 1 61  ? 5.74700   -36.47400 -15.41000 1.000 20.61000  ? 61  SER A CA   1 
ATOM   916  C C    . SER A 1 61  ? 5.48600   -35.24500 -14.53100 1.000 20.19000  ? 61  SER A C    1 
ATOM   917  O O    . SER A 1 61  ? 4.84800   -35.39000 -13.47000 1.000 21.64000  ? 61  SER A O    1 
ATOM   918  C CB   . SER A 1 61  ? 6.86500   -37.25400 -14.73700 1.000 21.32000  ? 61  SER A CB   1 
ATOM   919  O OG   . SER A 1 61  ? 8.13300   -36.62700 -15.02500 1.000 20.67000  ? 61  SER A OG   1 
ATOM   920  H H    . SER A 1 61  ? 6.92800   -36.31400 -16.98000 1.000 26.93000  ? 61  SER A H    1 
ATOM   921  H HA   . SER A 1 61  ? 4.95000   -37.02500 -15.47000 1.000 24.75000  ? 61  SER A HA   1 
ATOM   922  H HB2  . SER A 1 61  ? 6.72100   -37.25900 -13.77800 1.000 25.60000  ? 61  SER A HB2  1 
ATOM   923  H HB3  . SER A 1 61  ? 6.87200   -38.16300 -15.07600 1.000 25.60000  ? 61  SER A HB3  1 
ATOM   924  H HG   . SER A 1 61  ? 8.74700   -37.01400 -14.60100 1.000 24.83000  ? 61  SER A HG   1 
ATOM   925  N N    . GLU A 1 62  ? 6.00200   -34.09000 -14.90600 1.000 19.09000  ? 62  GLU A N    1 
ATOM   926  C CA   A GLU A 1 62  ? 5.74100   -32.80900 -14.26500 0.620 20.10000  ? 62  GLU A CA   1 
ATOM   927  C CA   B GLU A 1 62  ? 5.74800   -32.81600 -14.25300 0.380 20.25000  ? 62  GLU A CA   1 
ATOM   928  C C    . GLU A 1 62  ? 6.28400   -31.74100 -15.18700 1.000 22.38000  ? 62  GLU A C    1 
ATOM   929  O O    . GLU A 1 62  ? 7.48600   -31.43800 -15.17000 1.000 19.03000  ? 62  GLU A O    1 
ATOM   930  C CB   A GLU A 1 62  ? 6.40100   -32.70700 -12.90100 0.620 19.51000  ? 62  GLU A CB   1 
ATOM   931  C CB   B GLU A 1 62  ? 6.42600   -32.79000 -12.88400 0.380 19.87000  ? 62  GLU A CB   1 
ATOM   932  C CG   A GLU A 1 62  ? 6.25000   -31.29800 -12.29100 0.620 21.59000  ? 62  GLU A CG   1 
ATOM   933  C CG   B GLU A 1 62  ? 6.11100   -31.58400 -12.01100 0.380 22.83000  ? 62  GLU A CG   1 
ATOM   934  C CD   A GLU A 1 62  ? 4.86200   -30.69200 -12.50100 0.620 21.20000  ? 62  GLU A CD   1 
ATOM   935  C CD   B GLU A 1 62  ? 4.66900   -31.56600 -11.50600 0.380 31.14000  ? 62  GLU A CD   1 
ATOM   936  O OE1  A GLU A 1 62  ? 3.96800   -31.03800 -11.65600 0.620 27.99000  ? 62  GLU A OE1  1 
ATOM   937  O OE1  B GLU A 1 62  ? 4.17800   -32.59700 -10.98100 0.380 28.06000  ? 62  GLU A OE1  1 
ATOM   938  O OE2  A GLU A 1 62  ? 4.60000   -29.82900 -13.40000 0.620 18.72000  ? 62  GLU A OE2  1 
ATOM   939  O OE2  B GLU A 1 62  ? 4.03200   -30.49700 -11.58900 0.380 28.23000  ? 62  GLU A OE2  1 
ATOM   940  H H    . GLU A 1 62  ? 6.54100   -34.01300 -15.57100 1.000 22.93000  ? 62  GLU A H    1 
ATOM   941  H HA   . GLU A 1 62  ? 4.79000   -32.69400 -14.11800 1.000 24.32000  ? 62  GLU A HA   1 
ATOM   942  H HB2  A GLU A 1 62  ? 5.98700   -33.34500 -12.29900 0.620 23.43000  ? 62  GLU A HB2  1 
ATOM   943  H HB2  B GLU A 1 62  ? 6.15000   -33.58000 -12.39300 0.380 23.86000  ? 62  GLU A HB2  1 
ATOM   944  H HB3  A GLU A 1 62  ? 7.34700   -32.90000 -12.99000 0.620 23.43000  ? 62  GLU A HB3  1 
ATOM   945  H HB3  B GLU A 1 62  ? 7.38700   -32.80300 -13.02100 0.380 23.86000  ? 62  GLU A HB3  1 
ATOM   946  H HG2  A GLU A 1 62  ? 6.41000   -31.35100 -11.33600 0.620 25.93000  ? 62  GLU A HG2  1 
ATOM   947  H HG2  B GLU A 1 62  ? 6.69700   -31.59400 -11.23800 0.380 27.41000  ? 62  GLU A HG2  1 
ATOM   948  H HG3  A GLU A 1 62  ? 6.89800   -30.70600 -12.70400 0.620 25.93000  ? 62  GLU A HG3  1 
ATOM   949  H HG3  B GLU A 1 62  ? 6.25700   -30.77600 -12.52700 0.380 27.41000  ? 62  GLU A HG3  1 
ATOM   950  N N    . PRO A 1 63  ? 5.45500   -31.16200 -16.03600 1.000 19.73000  ? 63  PRO A N    1 
ATOM   951  C CA   . PRO A 1 63  ? 5.95600   -30.26800 -17.06200 1.000 20.72000  ? 63  PRO A CA   1 
ATOM   952  C C    . PRO A 1 63  ? 6.62100   -29.01600 -16.57700 1.000 18.73000  ? 63  PRO A C    1 
ATOM   953  O O    . PRO A 1 63  ? 7.38700   -28.43100 -17.32100 1.000 23.27000  ? 63  PRO A O    1 
ATOM   954  C CB   . PRO A 1 63  ? 4.67800   -29.91300 -17.84000 1.000 23.69000  ? 63  PRO A CB   1 
ATOM   955  C CG   . PRO A 1 63  ? 3.80600   -31.09000 -17.62100 1.000 26.83000  ? 63  PRO A CG   1 
ATOM   956  C CD   . PRO A 1 63  ? 4.01300   -31.48000 -16.20100 1.000 23.99000  ? 63  PRO A CD   1 
ATOM   957  H HA   . PRO A 1 63  ? 6.59000   -30.75600 -17.61000 1.000 24.88000  ? 63  PRO A HA   1 
ATOM   958  H HB2  . PRO A 1 63  ? 4.27900   -29.10600 -17.48000 1.000 28.45000  ? 63  PRO A HB2  1 
ATOM   959  H HB3  . PRO A 1 63  ? 4.88000   -29.79300 -18.78100 1.000 28.45000  ? 63  PRO A HB3  1 
ATOM   960  H HG2  . PRO A 1 63  ? 2.88100   -30.84700 -17.78000 1.000 32.21000  ? 63  PRO A HG2  1 
ATOM   961  H HG3  . PRO A 1 63  ? 4.06800   -31.80800 -18.21800 1.000 32.21000  ? 63  PRO A HG3  1 
ATOM   962  H HD2  . PRO A 1 63  ? 3.46200   -30.95100 -15.60400 1.000 28.81000  ? 63  PRO A HD2  1 
ATOM   963  H HD3  . PRO A 1 63  ? 3.84000   -32.42400 -16.06400 1.000 28.81000  ? 63  PRO A HD3  1 
ATOM   964  N N    . GLU A 1 64  ? 6.33700   -28.53700 -15.35900 1.000 17.92000  ? 64  GLU A N    1 
ATOM   965  C CA   . GLU A 1 64  ? 6.86100   -27.27300 -14.91700 1.000 17.87000  ? 64  GLU A CA   1 
ATOM   966  C C    . GLU A 1 64  ? 8.11600   -27.47400 -14.08300 1.000 17.81000  ? 64  GLU A C    1 
ATOM   967  O O    . GLU A 1 64  ? 8.19600   -28.42000 -13.32000 1.000 18.48000  ? 64  GLU A O    1 
ATOM   968  C CB   . GLU A 1 64  ? 5.85600   -26.53200 -14.06200 1.000 20.02000  ? 64  GLU A CB   1 
ATOM   969  C CG   . GLU A 1 64  ? 4.48000   -26.24200 -14.75200 1.000 23.88000  ? 64  GLU A CG   1 
ATOM   970  C CD   . GLU A 1 64  ? 4.62100   -25.46600 -16.01300 1.000 37.93000  ? 64  GLU A CD   1 
ATOM   971  O OE1  . GLU A 1 64  ? 5.40300   -24.49700 -16.02700 1.000 34.42000  ? 64  GLU A OE1  1 
ATOM   972  O OE2  . GLU A 1 64  ? 3.93500   -25.82500 -16.99500 1.000 40.24000  ? 64  GLU A OE2  1 
ATOM   973  H H    . GLU A 1 64  ? 5.84100   -28.93800 -14.78200 1.000 21.53000  ? 64  GLU A H    1 
ATOM   974  H HA   . GLU A 1 64  ? 7.06900   -26.74500 -15.70400 1.000 21.47000  ? 64  GLU A HA   1 
ATOM   975  H HB2  . GLU A 1 64  ? 5.67700   -27.06300 -13.27100 1.000 24.04000  ? 64  GLU A HB2  1 
ATOM   976  H HB3  . GLU A 1 64  ? 6.24000   -25.67800 -13.80900 1.000 24.04000  ? 64  GLU A HB3  1 
ATOM   977  H HG2  . GLU A 1 64  ? 4.04800   -27.08400 -14.96500 1.000 28.67000  ? 64  GLU A HG2  1 
ATOM   978  H HG3  . GLU A 1 64  ? 3.92400   -25.72800 -14.14500 1.000 28.67000  ? 64  GLU A HG3  1 
ATOM   979  N N    . LEU A 1 65  ? 9.06700   -26.57300 -14.23600 1.000 16.92000  ? 65  LEU A N    1 
ATOM   980  C CA   . LEU A 1 65  ? 10.35500  -26.59600 -13.54300 1.000 17.02000  ? 65  LEU A CA   1 
ATOM   981  C C    . LEU A 1 65  ? 10.32000  -25.49700 -12.47000 1.000 17.60000  ? 65  LEU A C    1 
ATOM   982  O O    . LEU A 1 65  ? 10.33100  -24.29100 -12.78000 1.000 18.76000  ? 65  LEU A O    1 
ATOM   983  C CB   . LEU A 1 65  ? 11.49100  -26.36500 -14.53700 1.000 15.80000  ? 65  LEU A CB   1 
ATOM   984  C CG   . LEU A 1 65  ? 11.64300  -27.42300 -15.58400 1.000 19.78000  ? 65  LEU A CG   1 
ATOM   985  C CD1  . LEU A 1 65  ? 12.88200  -27.13100 -16.43300 1.000 24.35000  ? 65  LEU A CD1  1 
ATOM   986  C CD2  . LEU A 1 65  ? 11.74100  -28.82500 -15.02800 1.000 21.22000  ? 65  LEU A CD2  1 
ATOM   987  H H    . LEU A 1 65  ? 8.99300   -25.89900 -14.76400 1.000 20.33000  ? 65  LEU A H    1 
ATOM   988  H HA   . LEU A 1 65  ? 10.49500  -27.45200 -13.10800 1.000 20.44000  ? 65  LEU A HA   1 
ATOM   989  H HB2  . LEU A 1 65  ? 11.33200  -25.52400 -14.99400 1.000 18.98000  ? 65  LEU A HB2  1 
ATOM   990  H HB3  . LEU A 1 65  ? 12.32500  -26.32100 -14.04400 1.000 18.98000  ? 65  LEU A HB3  1 
ATOM   991  H HG   . LEU A 1 65  ? 10.83900  -27.40000 -16.12600 1.000 23.76000  ? 65  LEU A HG   1 
ATOM   992  H HD11 . LEU A 1 65  ? 12.95300  -27.80100 -17.13000 1.000 29.24000  ? 65  LEU A HD11 1 
ATOM   993  H HD12 . LEU A 1 65  ? 12.79300  -26.24900 -16.82800 1.000 29.24000  ? 65  LEU A HD12 1 
ATOM   994  H HD13 . LEU A 1 65  ? 13.66800  -27.16000 -15.86500 1.000 29.24000  ? 65  LEU A HD13 1 
ATOM   995  H HD21 . LEU A 1 65  ? 12.14600  -29.40200 -15.69400 1.000 25.49000  ? 65  LEU A HD21 1 
ATOM   996  H HD22 . LEU A 1 65  ? 12.28800  -28.81000 -14.22700 1.000 25.49000  ? 65  LEU A HD22 1 
ATOM   997  H HD23 . LEU A 1 65  ? 10.85000  -29.14300 -14.81400 1.000 25.49000  ? 65  LEU A HD23 1 
ATOM   998  N N    . PHE A 1 66  ? 10.31900  -25.89500 -11.20100 1.000 14.75000  ? 66  PHE A N    1 
ATOM   999  C CA   . PHE A 1 66  ? 10.16100  -24.92800 -10.13400 1.000 15.33000  ? 66  PHE A CA   1 
ATOM   1000 C C    . PHE A 1 66  ? 10.81500  -25.42000 -8.84900  1.000 13.68000  ? 66  PHE A C    1 
ATOM   1001 O O    . PHE A 1 66  ? 11.05000  -26.62000 -8.65700  1.000 14.58000  ? 66  PHE A O    1 
ATOM   1002 C CB   . PHE A 1 66  ? 8.65600   -24.64200 -9.84800  1.000 14.96000  ? 66  PHE A CB   1 
ATOM   1003 C CG   . PHE A 1 66  ? 7.89000   -25.87300 -9.45100  1.000 15.16000  ? 66  PHE A CG   1 
ATOM   1004 C CD1  . PHE A 1 66  ? 7.83900   -26.26600 -8.12900  1.000 18.29000  ? 66  PHE A CD1  1 
ATOM   1005 C CD2  . PHE A 1 66  ? 7.23500   -26.66200 -10.39300 1.000 17.80000  ? 66  PHE A CD2  1 
ATOM   1006 C CE1  . PHE A 1 66  ? 7.19600   -27.42000 -7.72200  1.000 18.04000  ? 66  PHE A CE1  1 
ATOM   1007 C CE2  . PHE A 1 66  ? 6.53200   -27.81800 -9.98200  1.000 18.48000  ? 66  PHE A CE2  1 
ATOM   1008 C CZ   . PHE A 1 66  ? 6.52700   -28.17700 -8.65700  1.000 18.48000  ? 66  PHE A CZ   1 
ATOM   1009 H H    . PHE A 1 66  ? 10.40700  -26.71000 -10.94000 1.000 17.71000  ? 66  PHE A H    1 
ATOM   1010 H HA   . PHE A 1 66  ? 10.61400  -24.11500 -10.40900 1.000 18.41000  ? 66  PHE A HA   1 
ATOM   1011 H HB2  . PHE A 1 66  ? 8.58900   -24.00100 -9.12200  1.000 17.97000  ? 66  PHE A HB2  1 
ATOM   1012 H HB3  . PHE A 1 66  ? 8.24600   -24.28000 -10.64900 1.000 17.97000  ? 66  PHE A HB3  1 
ATOM   1013 H HD1  . PHE A 1 66  ? 8.25300   -25.73500 -7.48800  1.000 21.96000  ? 66  PHE A HD1  1 
ATOM   1014 H HD2  . PHE A 1 66  ? 7.25900   -26.42700 -11.29300 1.000 21.38000  ? 66  PHE A HD2  1 
ATOM   1015 H HE1  . PHE A 1 66  ? 7.21500   -27.68100 -6.83000  1.000 21.67000  ? 66  PHE A HE1  1 
ATOM   1016 H HE2  . PHE A 1 66  ? 6.07600   -28.33400 -10.60700 1.000 22.20000  ? 66  PHE A HE2  1 
ATOM   1017 H HZ   . PHE A 1 66  ? 6.06700   -28.94000 -8.38900  1.000 22.19000  ? 66  PHE A HZ   1 
ATOM   1018 N N    . ILE A 1 67  ? 11.04200  -24.44400 -7.94300  1.000 13.90000  ? 67  ILE A N    1 
ATOM   1019 C CA   . ILE A 1 67  ? 11.36100  -24.67600 -6.54400  1.000 15.37000  ? 67  ILE A CA   1 
ATOM   1020 C C    . ILE A 1 67  ? 10.24300  -24.03500 -5.73300  1.000 15.23000  ? 67  ILE A C    1 
ATOM   1021 O O    . ILE A 1 67  ? 9.77200   -22.94300 -6.07400  1.000 17.17000  ? 67  ILE A O    1 
ATOM   1022 C CB   . ILE A 1 67  ? 12.70400  -24.03600 -6.18800  1.000 13.95000  ? 67  ILE A CB   1 
ATOM   1023 C CG1  . ILE A 1 67  ? 13.79400  -24.64000 -7.09500  1.000 15.06000  ? 67  ILE A CG1  1 
ATOM   1024 C CG2  . ILE A 1 67  ? 13.05200  -24.18600 -4.69900  1.000 17.22000  ? 67  ILE A CG2  1 
ATOM   1025 C CD1  . ILE A 1 67  ? 15.11200  -23.94600 -6.99000  1.000 15.54000  ? 67  ILE A CD1  1 
ATOM   1026 H H    . ILE A 1 67  ? 11.01300  -23.60700 -8.13900  1.000 16.70000  ? 67  ILE A H    1 
ATOM   1027 H HA   . ILE A 1 67  ? 11.40600  -25.62500 -6.34900  1.000 18.47000  ? 67  ILE A HA   1 
ATOM   1028 H HB   . ILE A 1 67  ? 12.64300  -23.08100 -6.34500  1.000 16.76000  ? 67  ILE A HB   1 
ATOM   1029 H HG12 . ILE A 1 67  ? 13.92700  -25.56900 -6.84900  1.000 18.09000  ? 67  ILE A HG12 1 
ATOM   1030 H HG13 . ILE A 1 67  ? 13.50000  -24.58000 -8.01800  1.000 18.09000  ? 67  ILE A HG13 1 
ATOM   1031 H HG21 . ILE A 1 67  ? 13.94400  -23.83600 -4.54600  1.000 20.68000  ? 67  ILE A HG21 1 
ATOM   1032 H HG22 . ILE A 1 67  ? 12.40700  -23.68900 -4.17200  1.000 20.68000  ? 67  ILE A HG22 1 
ATOM   1033 H HG23 . ILE A 1 67  ? 13.02100  -25.12500 -4.46000  1.000 20.68000  ? 67  ILE A HG23 1 
ATOM   1034 H HD11 . ILE A 1 67  ? 15.64400  -24.15800 -7.77400  1.000 18.67000  ? 67  ILE A HD11 1 
ATOM   1035 H HD12 . ILE A 1 67  ? 14.96300  -22.98900 -6.94000  1.000 18.67000  ? 67  ILE A HD12 1 
ATOM   1036 H HD13 . ILE A 1 67  ? 15.56700  -24.25200 -6.19000  1.000 18.67000  ? 67  ILE A HD13 1 
ATOM   1037 N N    . ARG A 1 68  ? 9.74600   -24.73100 -4.71400  1.000 14.47000  ? 68  ARG A N    1 
ATOM   1038 C CA   . ARG A 1 68  ? 8.58500   -24.23400 -3.96800  1.000 14.17000  ? 68  ARG A CA   1 
ATOM   1039 C C    . ARG A 1 68  ? 8.84300   -24.45000 -2.48600  1.000 14.66000  ? 68  ARG A C    1 
ATOM   1040 O O    . ARG A 1 68  ? 9.18200   -25.56500 -2.03800  1.000 16.04000  ? 68  ARG A O    1 
ATOM   1041 C CB   . ARG A 1 68  ? 7.35100   -24.97600 -4.43400  1.000 14.89000  ? 68  ARG A CB   1 
ATOM   1042 C CG   . ARG A 1 68  ? 6.03300   -24.50600 -3.80300  1.000 17.51000  ? 68  ARG A CG   1 
ATOM   1043 C CD   . ARG A 1 68  ? 4.85100   -25.24200 -4.40100  1.000 20.06000  ? 68  ARG A CD   1 
ATOM   1044 N NE   . ARG A 1 68  ? 4.73700   -25.00600 -5.83900  1.000 19.69000  ? 68  ARG A NE   1 
ATOM   1045 C CZ   . ARG A 1 68  ? 4.16800   -25.82300 -6.71700  1.000 21.28000  ? 68  ARG A CZ   1 
ATOM   1046 N NH1  . ARG A 1 68  ? 3.58200   -26.92400 -6.33900  1.000 24.58000  ? 68  ARG A NH1  1 
ATOM   1047 N NH2  . ARG A 1 68  ? 4.21900   -25.52100 -8.01900  1.000 24.97000  ? 68  ARG A NH2  1 
ATOM   1048 H H    . ARG A 1 68  ? 10.05600  -25.48300 -4.43700  1.000 17.38000  ? 68  ARG A H    1 
ATOM   1049 H HA   . ARG A 1 68  ? 8.44600   -23.28300 -4.09800  1.000 17.02000  ? 68  ARG A HA   1 
ATOM   1050 H HB2  . ARG A 1 68  ? 7.27000   -24.86400 -5.39400  1.000 17.88000  ? 68  ARG A HB2  1 
ATOM   1051 H HB3  . ARG A 1 68  ? 7.45800   -25.91600 -4.21700  1.000 17.88000  ? 68  ARG A HB3  1 
ATOM   1052 H HG2  . ARG A 1 68  ? 6.05100   -24.68000 -2.84900  1.000 21.03000  ? 68  ARG A HG2  1 
ATOM   1053 H HG3  . ARG A 1 68  ? 5.91700   -23.55700 -3.96600  1.000 21.03000  ? 68  ARG A HG3  1 
ATOM   1054 H HD2  . ARG A 1 68  ? 4.96200   -26.19500 -4.25700  1.000 24.09000  ? 68  ARG A HD2  1 
ATOM   1055 H HD3  . ARG A 1 68  ? 4.03500   -24.93500 -3.97700  1.000 24.09000  ? 68  ARG A HD3  1 
ATOM   1056 H HE   . ARG A 1 68  ? 5.06800   -24.27300 -6.14300  1.000 23.64000  ? 68  ARG A HE   1 
ATOM   1057 H HH11 . ARG A 1 68  ? 3.55800   -27.13500 -5.50500  1.000 29.51000  ? 68  ARG A HH11 1 
ATOM   1058 H HH12 . ARG A 1 68  ? 3.21900   -27.44100 -6.92300  1.000 29.51000  ? 68  ARG A HH12 1 
ATOM   1059 H HH21 . ARG A 1 68  ? 4.61700   -24.80500 -8.27900  1.000 29.99000  ? 68  ARG A HH21 1 
ATOM   1060 H HH22 . ARG A 1 68  ? 3.85300   -26.04400 -8.59600  1.000 29.99000  ? 68  ARG A HH22 1 
ATOM   1061 N N    . ILE A 1 69  ? 8.63600   -23.38200 -1.71100  1.000 13.70000  ? 69  ILE A N    1 
ATOM   1062 C CA   . ILE A 1 69  ? 8.85700   -23.39300 -0.26600  1.000 13.13000  ? 69  ILE A CA   1 
ATOM   1063 C C    . ILE A 1 69  ? 7.48800   -23.32900 0.41000   1.000 14.40000  ? 69  ILE A C    1 
ATOM   1064 O O    . ILE A 1 69  ? 6.69600   -22.40700 0.11500   1.000 14.77000  ? 69  ILE A O    1 
ATOM   1065 C CB   . ILE A 1 69  ? 9.76400   -22.21900 0.15900   1.000 14.07000  ? 69  ILE A CB   1 
ATOM   1066 C CG1  . ILE A 1 69  ? 11.13900  -22.33600 -0.54700  1.000 15.51000  ? 69  ILE A CG1  1 
ATOM   1067 C CG2  . ILE A 1 69  ? 9.89700   -22.20500 1.64900   1.000 14.97000  ? 69  ILE A CG2  1 
ATOM   1068 C CD1  . ILE A 1 69  ? 11.93800  -21.03400 -0.51000  1.000 18.07000  ? 69  ILE A CD1  1 
ATOM   1069 H H    . ILE A 1 69  ? 8.36000   -22.62400 -2.00800  1.000 16.46000  ? 69  ILE A H    1 
ATOM   1070 H HA   . ILE A 1 69  ? 9.28400   -24.22000 0.00600   1.000 15.78000  ? 69  ILE A HA   1 
ATOM   1071 H HB   . ILE A 1 69  ? 9.36600   -21.37800 -0.11300  1.000 16.90000  ? 69  ILE A HB   1 
ATOM   1072 H HG12 . ILE A 1 69  ? 11.66300  -23.02200 -0.10500  1.000 18.63000  ? 69  ILE A HG12 1 
ATOM   1073 H HG13 . ILE A 1 69  ? 10.99700  -22.57500 -1.47600  1.000 18.63000  ? 69  ILE A HG13 1 
ATOM   1074 H HG21 . ILE A 1 69  ? 10.67800  -21.68400 1.89100   1.000 17.98000  ? 69  ILE A HG21 1 
ATOM   1075 H HG22 . ILE A 1 69  ? 9.10100   -21.80600 2.03300   1.000 17.98000  ? 69  ILE A HG22 1 
ATOM   1076 H HG23 . ILE A 1 69  ? 9.99500   -23.11600 1.96600   1.000 17.98000  ? 69  ILE A HG23 1 
ATOM   1077 H HD11 . ILE A 1 69  ? 12.70600  -21.11800 -1.09700  1.000 21.71000  ? 69  ILE A HD11 1 
ATOM   1078 H HD12 . ILE A 1 69  ? 11.37100  -20.30700 -0.81000  1.000 21.71000  ? 69  ILE A HD12 1 
ATOM   1079 H HD13 . ILE A 1 69  ? 12.23400  -20.87000 0.39900   1.000 21.71000  ? 69  ILE A HD13 1 
ATOM   1080 N N    . ILE A 1 70  ? 7.20900   -24.30100 1.27800   1.000 13.91000  ? 70  ILE A N    1 
ATOM   1081 C CA   . ILE A 1 70  ? 5.86600   -24.45600 1.87200   1.000 13.33000  ? 70  ILE A CA   1 
ATOM   1082 C C    . ILE A 1 70  ? 6.00100   -24.51000 3.39600   1.000 13.83000  ? 70  ILE A C    1 
ATOM   1083 O O    . ILE A 1 70  ? 6.26300   -25.58900 3.97400   1.000 14.56000  ? 70  ILE A O    1 
ATOM   1084 C CB   . ILE A 1 70  ? 5.11400   -25.67200 1.32700   1.000 15.00000  ? 70  ILE A CB   1 
ATOM   1085 C CG1  . ILE A 1 70  ? 5.17700   -25.77500 -0.20700  1.000 16.37000  ? 70  ILE A CG1  1 
ATOM   1086 C CG2  . ILE A 1 70  ? 3.69500   -25.57800 1.79100   1.000 16.90000  ? 70  ILE A CG2  1 
ATOM   1087 C CD1  . ILE A 1 70  ? 6.20100   -26.76700 -0.68500  1.000 23.91000  ? 70  ILE A CD1  1 
ATOM   1088 H H    . ILE A 1 70  ? 7.77800   -24.88900 1.54500   1.000 16.71000  ? 70  ILE A H    1 
ATOM   1089 H HA   . ILE A 1 70  ? 5.34200   -23.67500 1.63900   1.000 16.02000  ? 70  ILE A HA   1 
ATOM   1090 H HB   . ILE A 1 70  ? 5.54100   -26.47600 1.66400   1.000 18.02000  ? 70  ILE A HB   1 
ATOM   1091 H HG12 . ILE A 1 70  ? 4.31000   -26.05400 -0.54100  1.000 19.67000  ? 70  ILE A HG12 1 
ATOM   1092 H HG13 . ILE A 1 70  ? 5.40800   -24.90600 -0.57200  1.000 19.67000  ? 70  ILE A HG13 1 
ATOM   1093 H HG21 . ILE A 1 70  ? 3.18800   -26.31100 1.40700   1.000 20.30000  ? 70  ILE A HG21 1 
ATOM   1094 H HG22 . ILE A 1 70  ? 3.67500   -25.63400 2.75900   1.000 20.30000  ? 70  ILE A HG22 1 
ATOM   1095 H HG23 . ILE A 1 70  ? 3.32300   -24.73100 1.50100   1.000 20.30000  ? 70  ILE A HG23 1 
ATOM   1096 H HD11 . ILE A 1 70  ? 6.23200   -26.74700 -1.65500  1.000 28.71000  ? 70  ILE A HD11 1 
ATOM   1097 H HD12 . ILE A 1 70  ? 7.06700   -26.52700 -0.32200  1.000 28.71000  ? 70  ILE A HD12 1 
ATOM   1098 H HD13 . ILE A 1 70  ? 5.94800   -27.65300 -0.38100  1.000 28.71000  ? 70  ILE A HD13 1 
ATOM   1099 N N    . PRO A 1 71  ? 5.81800   -23.38400 4.09800   1.000 15.16000  ? 71  PRO A N    1 
ATOM   1100 C CA   . PRO A 1 71  ? 5.75000   -23.44400 5.57000   1.000 17.68000  ? 71  PRO A CA   1 
ATOM   1101 C C    . PRO A 1 71  ? 4.52800   -24.22100 6.01100   1.000 17.25000  ? 71  PRO A C    1 
ATOM   1102 O O    . PRO A 1 71  ? 3.44500   -23.98500 5.46200   1.000 20.24000  ? 71  PRO A O    1 
ATOM   1103 C CB   . PRO A 1 71  ? 5.62400   -21.95100 5.95800   1.000 19.19000  ? 71  PRO A CB   1 
ATOM   1104 C CG   . PRO A 1 71  ? 6.16100   -21.20200 4.81400   1.000 20.54000  ? 71  PRO A CG   1 
ATOM   1105 C CD   . PRO A 1 71  ? 5.74900   -21.99000 3.58300   1.000 18.54000  ? 71  PRO A CD   1 
ATOM   1106 H HA   . PRO A 1 71  ? 6.55300   -23.82900 5.95600   1.000 21.24000  ? 71  PRO A HA   1 
ATOM   1107 H HB2  . PRO A 1 71  ? 4.69200   -21.72900 6.11000   1.000 23.04000  ? 71  PRO A HB2  1 
ATOM   1108 H HB3  . PRO A 1 71  ? 6.14200   -21.77500 6.76000   1.000 23.04000  ? 71  PRO A HB3  1 
ATOM   1109 H HG2  . PRO A 1 71  ? 5.78000   -20.31100 4.79600   1.000 24.67000  ? 71  PRO A HG2  1 
ATOM   1110 H HG3  . PRO A 1 71  ? 7.12700   -21.14900 4.88100   1.000 24.67000  ? 71  PRO A HG3  1 
ATOM   1111 H HD2  . PRO A 1 71  ? 4.84900   -21.76100 3.30200   1.000 22.27000  ? 71  PRO A HD2  1 
ATOM   1112 H HD3  . PRO A 1 71  ? 6.37000   -21.85300 2.85100   1.000 22.27000  ? 71  PRO A HD3  1 
ATOM   1113 N N    . GLN A 1 72  ? 4.70500   -25.05800 7.02800   1.000 16.31000  ? 72  GLN A N    1 
ATOM   1114 C CA   . GLN A 1 72  ? 3.60800   -25.79700 7.66600   1.000 16.71000  ? 72  GLN A CA   1 
ATOM   1115 C C    . GLN A 1 72  ? 3.62500   -25.42300 9.14900   1.000 18.22000  ? 72  GLN A C    1 
ATOM   1116 O O    . GLN A 1 72  ? 4.19000   -26.14600 9.97700   1.000 19.67000  ? 72  GLN A O    1 
ATOM   1117 C CB   . GLN A 1 72  ? 3.74600   -27.29000 7.43600   1.000 18.37000  ? 72  GLN A CB   1 
ATOM   1118 C CG   . GLN A 1 72  ? 3.80900   -27.73200 5.93000   1.000 19.57000  ? 72  GLN A CG   1 
ATOM   1119 C CD   . GLN A 1 72  ? 2.46500   -27.87000 5.29500   1.000 27.67000  ? 72  GLN A CD   1 
ATOM   1120 O OE1  . GLN A 1 72  ? 1.42600   -27.63600 5.92900   1.000 24.10000  ? 72  GLN A OE1  1 
ATOM   1121 N NE2  . GLN A 1 72  ? 2.45700   -28.26900 4.03200   1.000 26.15000  ? 72  GLN A NE2  1 
ATOM   1122 H H    . GLN A 1 72  ? 5.47200   -25.22300 7.37900   1.000 19.59000  ? 72  GLN A H    1 
ATOM   1123 H HA   . GLN A 1 72  ? 2.75900   -25.52600 7.28400   1.000 20.07000  ? 72  GLN A HA   1 
ATOM   1124 H HB2  . GLN A 1 72  ? 4.56400   -27.59100 7.86100   1.000 22.06000  ? 72  GLN A HB2  1 
ATOM   1125 H HB3  . GLN A 1 72  ? 2.98100   -27.73300 7.83700   1.000 22.06000  ? 72  GLN A HB3  1 
ATOM   1126 H HG2  . GLN A 1 72  ? 4.30700   -27.06700 5.42900   1.000 23.51000  ? 72  GLN A HG2  1 
ATOM   1127 H HG3  . GLN A 1 72  ? 4.25400   -28.59200 5.87400   1.000 23.51000  ? 72  GLN A HG3  1 
ATOM   1128 H HE21 . GLN A 1 72  ? 3.19900   -28.43100 3.62700   1.000 31.40000  ? 72  GLN A HE21 1 
ATOM   1129 H HE22 . GLN A 1 72  ? 1.71100   -28.36500 3.61600   1.000 31.40000  ? 72  GLN A HE22 1 
ATOM   1130 N N    . LYS A 1 73  ? 3.03100   -24.26900 9.46500   1.000 20.14000  ? 73  LYS A N    1 
ATOM   1131 C CA   . LYS A 1 73  ? 3.22300   -23.69300 10.79500  1.000 19.70000  ? 73  LYS A CA   1 
ATOM   1132 C C    . LYS A 1 73  ? 2.71800   -24.60900 11.88900  1.000 24.23000  ? 73  LYS A C    1 
ATOM   1133 O O    . LYS A 1 73  ? 3.39000   -24.76400 12.90700  1.000 24.27000  ? 73  LYS A O    1 
ATOM   1134 C CB   . LYS A 1 73  ? 2.54200   -22.34600 10.86600  1.000 23.86000  ? 73  LYS A CB   1 
ATOM   1135 C CG   . LYS A 1 73  ? 3.33500   -21.30100 10.15500  1.000 26.06000  ? 73  LYS A CG   1 
ATOM   1136 C CD   . LYS A 1 73  ? 2.72300   -19.92400 10.35500  1.000 26.88000  ? 73  LYS A CD   1 
ATOM   1137 C CE   . LYS A 1 73  ? 3.60800   -18.83700 9.72000   1.000 39.56000  ? 73  LYS A CE   1 
ATOM   1138 N NZ   . LYS A 1 73  ? 2.97100   -17.47200 9.85500   1.000 42.18000  ? 73  LYS A NZ   1 
ATOM   1139 H H    . LYS A 1 73  ? 2.52500   -23.81200 8.94100   1.000 24.19000  ? 73  LYS A H    1 
ATOM   1140 H HA   . LYS A 1 73  ? 4.17300   -23.56700 10.94500  1.000 23.66000  ? 73  LYS A HA   1 
ATOM   1141 H HB2  . LYS A 1 73  ? 1.66800   -22.40500 10.44900  1.000 28.65000  ? 73  LYS A HB2  1 
ATOM   1142 H HB3  . LYS A 1 73  ? 2.44900   -22.08100 11.79500  1.000 28.65000  ? 73  LYS A HB3  1 
ATOM   1143 H HG2  . LYS A 1 73  ? 4.24000   -21.28800 10.50400  1.000 31.30000  ? 73  LYS A HG2  1 
ATOM   1144 H HG3  . LYS A 1 73  ? 3.34800   -21.49600 9.20500   1.000 31.30000  ? 73  LYS A HG3  1 
ATOM   1145 H HD2  . LYS A 1 73  ? 1.84900   -19.89300 9.93500   1.000 32.28000  ? 73  LYS A HD2  1 
ATOM   1146 H HD3  . LYS A 1 73  ? 2.64200   -19.73900 11.30400  1.000 32.28000  ? 73  LYS A HD3  1 
ATOM   1147 H HE2  . LYS A 1 73  ? 4.46900   -18.82000 10.16600  1.000 47.49000  ? 73  LYS A HE2  1 
ATOM   1148 H HE3  . LYS A 1 73  ? 3.72700   -19.02900 8.77600   1.000 47.49000  ? 73  LYS A HE3  1 
ATOM   1149 H HZ1  . LYS A 1 73  ? 2.20500   -17.44700 9.40300   1.000 50.64000  ? 73  LYS A HZ1  1 
ATOM   1150 H HZ2  . LYS A 1 73  ? 2.80700   -17.29600 10.71200  1.000 50.64000  ? 73  LYS A HZ2  1 
ATOM   1151 H HZ3  . LYS A 1 73  ? 3.51700   -16.84800 9.53100   1.000 50.64000  ? 73  LYS A HZ3  1 
ATOM   1152 N N    . ASP A 1 74  ? 1.54900   -25.23800 11.68800  1.000 23.62000  ? 74  ASP A N    1 
ATOM   1153 C CA   . ASP A 1 74  ? 0.99700   -26.03000 12.78000  1.000 29.45000  ? 74  ASP A CA   1 
ATOM   1154 C C    . ASP A 1 74  ? 1.87300   -27.23300 13.09800  1.000 33.25000  ? 74  ASP A C    1 
ATOM   1155 O O    . ASP A 1 74  ? 1.90000   -27.70100 14.22900  1.000 32.85000  ? 74  ASP A O    1 
ATOM   1156 C CB   . ASP A 1 74  ? -0.41200  -26.53000 12.43800  1.000 37.74000  ? 74  ASP A CB   1 
ATOM   1157 C CG   . ASP A 1 74  ? -1.46900  -25.42200 12.41500  1.000 48.01000  ? 74  ASP A CG   1 
ATOM   1158 O OD1  . ASP A 1 74  ? -1.25200  -24.34100 13.00200  1.000 37.13000  ? 74  ASP A OD1  1 
ATOM   1159 O OD2  . ASP A 1 74  ? -2.53300  -25.66200 11.79500  1.000 45.38000  ? 74  ASP A OD2  1 
ATOM   1160 H H    . ASP A 1 74  ? 1.08500   -25.21900 10.96400  1.000 28.36000  ? 74  ASP A H    1 
ATOM   1161 H HA   . ASP A 1 74  ? 0.94200   -25.45500 13.55900  1.000 35.36000  ? 74  ASP A HA   1 
ATOM   1162 H HB2  . ASP A 1 74  ? -0.39400  -26.93900 11.55900  1.000 45.30000  ? 74  ASP A HB2  1 
ATOM   1163 H HB3  . ASP A 1 74  ? -0.68200  -27.18300 13.10200  1.000 45.30000  ? 74  ASP A HB3  1 
ATOM   1164 N N    . GLN A 1 75  ? 2.59400   -27.75100 12.10800  1.000 24.27000  ? 75  GLN A N    1 
ATOM   1165 C CA   . GLN A 1 75  ? 3.47300   -28.87200 12.30200  1.000 21.41000  ? 75  GLN A CA   1 
ATOM   1166 C C    . GLN A 1 75  ? 4.91200   -28.48200 12.66700  1.000 18.32000  ? 75  GLN A C    1 
ATOM   1167 O O    . GLN A 1 75  ? 5.73000   -29.37400 12.93000  1.000 21.45000  ? 75  GLN A O    1 
ATOM   1168 C CB   . GLN A 1 75  ? 3.55400   -29.69400 11.03900  1.000 25.55000  ? 75  GLN A CB   1 
ATOM   1169 C CG   . GLN A 1 75  ? 2.20500   -30.13300 10.41600  1.000 31.35000  ? 75  GLN A CG   1 
ATOM   1170 C CD   . GLN A 1 75  ? 2.44000   -30.89000 9.09700   1.000 56.26000  ? 75  GLN A CD   1 
ATOM   1171 O OE1  . GLN A 1 75  ? 1.85200   -30.56100 8.07000   1.000 41.48000  ? 75  GLN A OE1  1 
ATOM   1172 N NE2  . GLN A 1 75  ? 3.31900   -31.88800 9.12700   1.000 44.40000  ? 75  GLN A NE2  1 
ATOM   1173 H H    . GLN A 1 75  ? 2.58400   -27.45600 11.30100  1.000 29.15000  ? 75  GLN A H    1 
ATOM   1174 H HA   . GLN A 1 75  ? 3.10000   -29.40400 13.02200  1.000 25.71000  ? 75  GLN A HA   1 
ATOM   1175 H HB2  . GLN A 1 75  ? 4.02100   -29.17200 10.36900  1.000 30.68000  ? 75  GLN A HB2  1 
ATOM   1176 H HB3  . GLN A 1 75  ? 4.05200   -30.50300 11.23700  1.000 30.68000  ? 75  GLN A HB3  1 
ATOM   1177 H HG2  . GLN A 1 75  ? 1.74000   -30.72000 11.03100  1.000 37.63000  ? 75  GLN A HG2  1 
ATOM   1178 H HG3  . GLN A 1 75  ? 1.66400   -29.35000 10.23100  1.000 37.63000  ? 75  GLN A HG3  1 
ATOM   1179 H HE21 . GLN A 1 75  ? 3.72500   -32.08200 9.86000   1.000 53.30000  ? 75  GLN A HE21 1 
ATOM   1180 H HE22 . GLN A 1 75  ? 3.48200   -32.34000 8.41400   1.000 53.30000  ? 75  GLN A HE22 1 
ATOM   1181 N N    . LYS A 1 76  ? 5.24200   -27.19100 12.63400  1.000 20.80000  ? 76  LYS A N    1 
ATOM   1182 C CA   . LYS A 1 76  ? 6.61300   -26.72100 12.84300  1.000 18.43000  ? 76  LYS A CA   1 
ATOM   1183 C C    . LYS A 1 76  ? 7.54500   -27.36500 11.81600  1.000 17.64000  ? 76  LYS A C    1 
ATOM   1184 O O    . LYS A 1 76  ? 8.64600   -27.76600 12.12800  1.000 18.70000  ? 76  LYS A O    1 
ATOM   1185 C CB   . LYS A 1 76  ? 7.10800   -26.99200 14.28900  1.000 22.59000  ? 76  LYS A CB   1 
ATOM   1186 C CG   . LYS A 1 76  ? 6.31200   -26.08700 15.28400  1.000 27.06000  ? 76  LYS A CG   1 
ATOM   1187 C CD   . LYS A 1 76  ? 6.68200   -26.42000 16.71100  1.000 28.33000  ? 76  LYS A CD   1 
ATOM   1188 C CE   . LYS A 1 76  ? 5.91600   -25.55300 17.70800  1.000 48.58000  ? 76  LYS A CE   1 
ATOM   1189 N NZ   . LYS A 1 76  ? 6.18700   -26.01300 19.09400  1.000 47.70000  ? 76  LYS A NZ   1 
ATOM   1190 H H    . LYS A 1 76  ? 4.68000   -26.55500 12.49000  1.000 24.98000  ? 76  LYS A H    1 
ATOM   1191 H HA   . LYS A 1 76  ? 6.63500   -25.75900 12.71800  1.000 22.14000  ? 76  LYS A HA   1 
ATOM   1192 H HB2  . LYS A 1 76  ? 6.95700   -27.92200 14.52000  1.000 27.12000  ? 76  LYS A HB2  1 
ATOM   1193 H HB3  . LYS A 1 76  ? 8.05200   -26.78200 14.35900  1.000 27.12000  ? 76  LYS A HB3  1 
ATOM   1194 H HG2  . LYS A 1 76  ? 6.52600   -25.15500 15.11800  1.000 32.49000  ? 76  LYS A HG2  1 
ATOM   1195 H HG3  . LYS A 1 76  ? 5.36100   -26.23400 15.16800  1.000 32.49000  ? 76  LYS A HG3  1 
ATOM   1196 H HD2  . LYS A 1 76  ? 6.46800   -27.34900 16.88900  1.000 34.02000  ? 76  LYS A HD2  1 
ATOM   1197 H HD3  . LYS A 1 76  ? 7.63100   -26.26700 16.84000  1.000 34.02000  ? 76  LYS A HD3  1 
ATOM   1198 H HE2  . LYS A 1 76  ? 6.20200   -24.63000 17.62500  1.000 58.32000  ? 76  LYS A HE2  1 
ATOM   1199 H HE3  . LYS A 1 76  ? 4.96400   -25.62200 17.53800  1.000 58.32000  ? 76  LYS A HE3  1 
ATOM   1200 H HZ1  . LYS A 1 76  ? 7.04400   -25.88400 19.29500  1.000 57.27000  ? 76  LYS A HZ1  1 
ATOM   1201 H HZ2  . LYS A 1 76  ? 5.68300   -25.55800 19.67000  1.000 57.27000  ? 76  LYS A HZ2  1 
ATOM   1202 H HZ3  . LYS A 1 76  ? 6.00000   -26.88000 19.16900  1.000 57.27000  ? 76  LYS A HZ3  1 
ATOM   1203 N N    . VAL A 1 77  ? 7.06700   -27.39400 10.56800  1.000 16.69000  ? 77  VAL A N    1 
ATOM   1204 C CA   . VAL A 1 77  ? 7.78300   -28.03900 9.46800   1.000 16.04000  ? 77  VAL A CA   1 
ATOM   1205 C C    . VAL A 1 77  ? 7.91700   -27.03000 8.35400   1.000 13.89000  ? 77  VAL A C    1 
ATOM   1206 O O    . VAL A 1 77  ? 6.97000   -26.30000 8.00900   1.000 18.02000  ? 77  VAL A O    1 
ATOM   1207 C CB   . VAL A 1 77  ? 6.99200   -29.24600 8.95400   1.000 18.77000  ? 77  VAL A CB   1 
ATOM   1208 C CG1  . VAL A 1 77  ? 7.34400   -29.58600 7.49900   1.000 21.22000  ? 77  VAL A CG1  1 
ATOM   1209 C CG2  . VAL A 1 77  ? 7.26900   -30.44700 9.82100   1.000 17.64000  ? 77  VAL A CG2  1 
ATOM   1210 H H    . VAL A 1 77  ? 6.31900   -27.04100 10.33300  1.000 20.04000  ? 77  VAL A H    1 
ATOM   1211 H HA   . VAL A 1 77  ? 8.66300   -28.32200 9.76100   1.000 19.26000  ? 77  VAL A HA   1 
ATOM   1212 H HB   . VAL A 1 77  ? 6.05000   -29.01800 8.99000   1.000 22.54000  ? 77  VAL A HB   1 
ATOM   1213 H HG11 . VAL A 1 77  ? 6.98300   -30.46100 7.28300   1.000 25.48000  ? 77  VAL A HG11 1 
ATOM   1214 H HG12 . VAL A 1 77  ? 6.95700   -28.91600 6.91500   1.000 25.48000  ? 77  VAL A HG12 1 
ATOM   1215 H HG13 . VAL A 1 77  ? 8.30900   -29.59300 7.40100   1.000 25.48000  ? 77  VAL A HG13 1 
ATOM   1216 H HG21 . VAL A 1 77  ? 6.77900   -31.20800 9.47100   1.000 21.18000  ? 77  VAL A HG21 1 
ATOM   1217 H HG22 . VAL A 1 77  ? 8.22100   -30.63300 9.80800   1.000 21.18000  ? 77  VAL A HG22 1 
ATOM   1218 H HG23 . VAL A 1 77  ? 6.98100   -30.25600 10.72700  1.000 21.18000  ? 77  VAL A HG23 1 
ATOM   1219 N N    . LEU A 1 78  ? 9.09400   -27.02200 7.73800   1.000 14.18000  ? 78  LEU A N    1 
ATOM   1220 C CA   . LEU A 1 78  ? 9.32500   -26.26300 6.51100   1.000 15.04000  ? 78  LEU A CA   1 
ATOM   1221 C C    . LEU A 1 78  ? 9.58300   -27.26000 5.37000   1.000 13.55000  ? 78  LEU A C    1 
ATOM   1222 O O    . LEU A 1 78  ? 10.49500  -28.06900 5.47100   1.000 14.52000  ? 78  LEU A O    1 
ATOM   1223 C CB   . LEU A 1 78  ? 10.52300  -25.32700 6.65400   1.000 14.12000  ? 78  LEU A CB   1 
ATOM   1224 C CG   . LEU A 1 78  ? 10.81300  -24.43800 5.41700   1.000 15.04000  ? 78  LEU A CG   1 
ATOM   1225 C CD1  . LEU A 1 78  ? 9.71600   -23.43800 5.10400   1.000 15.63000  ? 78  LEU A CD1  1 
ATOM   1226 C CD2  . LEU A 1 78  ? 12.08400  -23.69800 5.63300   1.000 16.73000  ? 78  LEU A CD2  1 
ATOM   1227 H H    . LEU A 1 78  ? 9.78300   -27.45500 8.01400   1.000 17.04000  ? 78  LEU A H    1 
ATOM   1228 H HA   . LEU A 1 78  ? 8.54000   -25.73100 6.30900   1.000 18.06000  ? 78  LEU A HA   1 
ATOM   1229 H HB2  . LEU A 1 78  ? 10.36100  -24.73600 7.40600   1.000 16.97000  ? 78  LEU A HB2  1 
ATOM   1230 H HB3  . LEU A 1 78  ? 11.31300  -25.86500 6.81900   1.000 16.97000  ? 78  LEU A HB3  1 
ATOM   1231 H HG   . LEU A 1 78  ? 10.87200  -25.03100 4.65100   1.000 18.07000  ? 78  LEU A HG   1 
ATOM   1232 H HD11 . LEU A 1 78  ? 10.06000  -22.77600 4.48400   1.000 18.78000  ? 78  LEU A HD11 1 
ATOM   1233 H HD12 . LEU A 1 78  ? 8.96600   -23.90700 4.70500   1.000 18.78000  ? 78  LEU A HD12 1 
ATOM   1234 H HD13 . LEU A 1 78  ? 9.43700   -23.00800 5.92700   1.000 18.78000  ? 78  LEU A HD13 1 
ATOM   1235 H HD21 . LEU A 1 78  ? 12.28700  -23.18100 4.83800   1.000 20.09000  ? 78  LEU A HD21 1 
ATOM   1236 H HD22 . LEU A 1 78  ? 11.97900  -23.10700 6.39500   1.000 20.09000  ? 78  LEU A HD22 1 
ATOM   1237 H HD23 . LEU A 1 78  ? 12.79500  -24.33500 5.80400   1.000 20.09000  ? 78  LEU A HD23 1 
ATOM   1238 N N    . GLU A 1 79  ? 8.77200   -27.18300 4.32800   1.000 13.54000  ? 79  GLU A N    1 
ATOM   1239 C CA   . GLU A 1 79  ? 8.97500   -28.04700 3.15600   1.000 14.57000  ? 79  GLU A CA   1 
ATOM   1240 C C    . GLU A 1 79  ? 9.60700   -27.28000 2.02000   1.000 14.48000  ? 79  GLU A C    1 
ATOM   1241 O O    . GLU A 1 79  ? 9.26500   -26.12900 1.76800   1.000 14.46000  ? 79  GLU A O    1 
ATOM   1242 C CB   . GLU A 1 79  ? 7.64000   -28.60400 2.69200   1.000 14.47000  ? 79  GLU A CB   1 
ATOM   1243 C CG   . GLU A 1 79  ? 6.96600   -29.52100 3.70800   1.000 16.43000  ? 79  GLU A CG   1 
ATOM   1244 C CD   . GLU A 1 79  ? 5.54200   -29.96500 3.36900   1.000 16.39000  ? 79  GLU A CD   1 
ATOM   1245 O OE1  . GLU A 1 79  ? 4.84000   -29.25400 2.64300   1.000 19.58000  ? 79  GLU A OE1  1 
ATOM   1246 O OE2  . GLU A 1 79  ? 5.15200   -31.05500 3.89500   1.000 22.14000  ? 79  GLU A OE2  1 
ATOM   1247 H H    . GLU A 1 79  ? 8.10200   -26.64700 4.26900   1.000 16.27000  ? 79  GLU A H    1 
ATOM   1248 H HA   . GLU A 1 79  ? 9.57300   -28.77300 3.39400   1.000 17.51000  ? 79  GLU A HA   1 
ATOM   1249 H HB2  . GLU A 1 79  ? 7.03800   -27.86300 2.51700   1.000 17.38000  ? 79  GLU A HB2  1 
ATOM   1250 H HB3  . GLU A 1 79  ? 7.78100   -29.11600 1.88000   1.000 17.38000  ? 79  GLU A HB3  1 
ATOM   1251 H HG2  . GLU A 1 79  ? 7.50300   -30.32400 3.79600   1.000 19.74000  ? 79  GLU A HG2  1 
ATOM   1252 H HG3  . GLU A 1 79  ? 6.92500   -29.05400 4.55800   1.000 19.74000  ? 79  GLU A HG3  1 
ATOM   1253 N N    . ILE A 1 80  ? 10.54700  -27.92800 1.32200   1.000 14.45000  ? 80  ILE A N    1 
ATOM   1254 C CA   . ILE A 1 80  ? 11.17900  -27.37700 0.12400   1.000 15.20000  ? 80  ILE A CA   1 
ATOM   1255 C C    . ILE A 1 80  ? 11.06200  -28.42200 -0.98300  1.000 14.02000  ? 80  ILE A C    1 
ATOM   1256 O O    . ILE A 1 80  ? 11.70200  -29.48200 -0.90400  1.000 13.78000  ? 80  ILE A O    1 
ATOM   1257 C CB   . ILE A 1 80  ? 12.62100  -27.02300 0.37800   1.000 14.90000  ? 80  ILE A CB   1 
ATOM   1258 C CG1  . ILE A 1 80  ? 12.80600  -26.08300 1.61100   1.000 22.06000  ? 80  ILE A CG1  1 
ATOM   1259 C CG2  . ILE A 1 80  ? 13.26000  -26.37900 -0.85000  1.000 20.24000  ? 80  ILE A CG2  1 
ATOM   1260 C CD1  . ILE A 1 80  ? 13.09100  -26.80100 2.82100   1.000 31.68000  ? 80  ILE A CD1  1 
ATOM   1261 H H    . ILE A 1 80  ? 10.84000  -28.70900 1.53100   1.000 17.36000  ? 80  ILE A H    1 
ATOM   1262 H HA   . ILE A 1 80  ? 10.70300  -26.58200 -0.16400  1.000 18.26000  ? 80  ILE A HA   1 
ATOM   1263 H HB   . ILE A 1 80  ? 13.06500  -27.86300 0.57300   1.000 17.90000  ? 80  ILE A HB   1 
ATOM   1264 H HG12 . ILE A 1 80  ? 13.54500  -25.47900 1.44000   1.000 26.49000  ? 80  ILE A HG12 1 
ATOM   1265 H HG13 . ILE A 1 80  ? 11.98900  -25.57800 1.74800   1.000 26.49000  ? 80  ILE A HG13 1 
ATOM   1266 H HG21 . ILE A 1 80  ? 14.15000  -26.06900 -0.61700  1.000 24.30000  ? 80  ILE A HG21 1 
ATOM   1267 H HG22 . ILE A 1 80  ? 13.31500  -27.03800 -1.55900  1.000 24.30000  ? 80  ILE A HG22 1 
ATOM   1268 H HG23 . ILE A 1 80  ? 12.71400  -25.63000 -1.13400  1.000 24.30000  ? 80  ILE A HG23 1 
ATOM   1269 H HD11 . ILE A 1 80  ? 13.11600  -26.17400 3.56200   1.000 38.03000  ? 80  ILE A HD11 1 
ATOM   1270 H HD12 . ILE A 1 80  ? 12.39600  -27.46000 2.96900   1.000 38.03000  ? 80  ILE A HD12 1 
ATOM   1271 H HD13 . ILE A 1 80  ? 13.95100  -27.24100 2.73200   1.000 38.03000  ? 80  ILE A HD13 1 
ATOM   1272 N N    . ARG A 1 81  ? 10.28400  -28.10400 -2.00200  1.000 14.36000  ? 81  ARG A N    1 
ATOM   1273 C CA   . ARG A 1 81  ? 9.94300   -29.01600 -3.08300  1.000 12.94000  ? 81  ARG A CA   1 
ATOM   1274 C C    . ARG A 1 81  ? 10.59900  -28.52600 -4.36000  1.000 15.82000  ? 81  ARG A C    1 
ATOM   1275 O O    . ARG A 1 81  ? 10.68700  -27.32400 -4.59900  1.000 17.58000  ? 81  ARG A O    1 
ATOM   1276 C CB   . ARG A 1 81  ? 8.43100   -29.08100 -3.22800  1.000 15.18000  ? 81  ARG A CB   1 
ATOM   1277 C CG   . ARG A 1 81  ? 7.99500   -29.97200 -4.46600  1.000 17.22000  ? 81  ARG A CG   1 
ATOM   1278 C CD   . ARG A 1 81  ? 6.42000   -30.11600 -4.61200  1.000 20.62000  ? 81  ARG A CD   1 
ATOM   1279 N NE   . ARG A 1 81  ? 6.01400   -30.87300 -5.80000  1.000 19.24000  ? 81  ARG A NE   1 
ATOM   1280 C CZ   . ARG A 1 81  ? 4.77600   -31.03400 -6.17500  1.000 27.62000  ? 81  ARG A CZ   1 
ATOM   1281 N NH1  . ARG A 1 81  ? 3.78500   -30.51200 -5.47600  1.000 33.00000  ? 81  ARG A NH1  1 
ATOM   1282 N NH2  . ARG A 1 81  ? 4.53500   -31.69000 -7.28800  1.000 26.76000  ? 81  ARG A NH2  1 
ATOM   1283 H H    . ARG A 1 81  ? 9.92400   -27.32900 -2.09700  1.000 17.26000  ? 81  ARG A H    1 
ATOM   1284 H HA   . ARG A 1 81  ? 10.26900  -29.91400 -2.91400  1.000 15.55000  ? 81  ARG A HA   1 
ATOM   1285 H HB2  . ARG A 1 81  ? 8.04900   -29.47000 -2.42400  1.000 18.23000  ? 81  ARG A HB2  1 
ATOM   1286 H HB3  . ARG A 1 81  ? 8.08300   -28.18500 -3.36000  1.000 18.23000  ? 81  ARG A HB3  1 
ATOM   1287 H HG2  . ARG A 1 81  ? 8.33300   -29.56600 -5.28000  1.000 20.69000  ? 81  ARG A HG2  1 
ATOM   1288 H HG3  . ARG A 1 81  ? 8.36700   -30.86100 -4.36000  1.000 20.69000  ? 81  ARG A HG3  1 
ATOM   1289 H HD2  . ARG A 1 81  ? 6.07400   -30.57800 -3.83200  1.000 24.76000  ? 81  ARG A HD2  1 
ATOM   1290 H HD3  . ARG A 1 81  ? 6.02800   -29.23100 -4.67400  1.000 24.76000  ? 81  ARG A HD3  1 
ATOM   1291 H HE   . ARG A 1 81  ? 6.63000   -31.23200 -6.28000  1.000 23.11000  ? 81  ARG A HE   1 
ATOM   1292 H HH11 . ARG A 1 81  ? 3.95200   -30.05900 -4.76400  1.000 39.62000  ? 81  ARG A HH11 1 
ATOM   1293 H HH12 . ARG A 1 81  ? 2.97200   -30.62500 -5.73300  1.000 39.62000  ? 81  ARG A HH12 1 
ATOM   1294 H HH21 . ARG A 1 81  ? 5.18700   -32.00400 -7.75200  1.000 32.14000  ? 81  ARG A HH21 1 
ATOM   1295 H HH22 . ARG A 1 81  ? 3.72400   -31.80700 -7.55100  1.000 32.14000  ? 81  ARG A HH22 1 
ATOM   1296 N N    . ASP A 1 82  ? 11.05400  -29.44400 -5.18500  1.000 13.71000  ? 82  ASP A N    1 
ATOM   1297 C CA   . ASP A 1 82  ? 11.49600  -29.10500 -6.53300  1.000 12.83000  ? 82  ASP A CA   1 
ATOM   1298 C C    . ASP A 1 82  ? 10.93600  -30.14000 -7.47800  1.000 12.06000  ? 82  ASP A C    1 
ATOM   1299 O O    . ASP A 1 82  ? 10.61000  -31.24500 -7.07700  1.000 13.44000  ? 82  ASP A O    1 
ATOM   1300 C CB   . ASP A 1 82  ? 13.03800  -29.00000 -6.64500  1.000 12.43000  ? 82  ASP A CB   1 
ATOM   1301 C CG   . ASP A 1 82  ? 13.76800  -30.27900 -6.41300  1.000 13.26000  ? 82  ASP A CG   1 
ATOM   1302 O OD1  . ASP A 1 82  ? 13.60900  -31.16600 -7.26800  1.000 13.89000  ? 82  ASP A OD1  1 
ATOM   1303 O OD2  . ASP A 1 82  ? 14.49200  -30.45700 -5.38700  1.000 13.57000  ? 82  ASP A OD2  1 
ATOM   1304 H H    . ASP A 1 82  ? 11.12000  -30.28000 -4.99200  1.000 16.47000  ? 82  ASP A H    1 
ATOM   1305 H HA   . ASP A 1 82  ? 11.14900  -28.23700 -6.78900  1.000 15.42000  ? 82  ASP A HA   1 
ATOM   1306 H HB2  . ASP A 1 82  ? 13.26200  -28.69500 -7.53800  1.000 14.94000  ? 82  ASP A HB2  1 
ATOM   1307 H HB3  . ASP A 1 82  ? 13.35300  -28.36100 -5.98700  1.000 14.94000  ? 82  ASP A HB3  1 
ATOM   1308 N N    . SER A 1 83  ? 10.89200  -29.76400 -8.74500  1.000 13.35000  ? 83  SER A N    1 
ATOM   1309 C CA   . SER A 1 83  ? 10.52400  -30.69700 -9.81300  1.000 14.96000  ? 83  SER A CA   1 
ATOM   1310 C C    . SER A 1 83  ? 11.73800  -31.11000 -10.63100 1.000 13.81000  ? 83  SER A C    1 
ATOM   1311 O O    . SER A 1 83  ? 11.65600  -31.32600 -11.86400 1.000 15.83000  ? 83  SER A O    1 
ATOM   1312 C CB   . SER A 1 83  ? 9.42300   -30.10300 -10.68100 1.000 13.37000  ? 83  SER A CB   1 
ATOM   1313 O OG   . SER A 1 83  ? 9.81000   -28.87300 -11.24800 1.000 15.07000  ? 83  SER A OG   1 
ATOM   1314 H H    . SER A 1 83  ? 11.07100  -28.96800 -9.02000  1.000 16.03000  ? 83  SER A H    1 
ATOM   1315 H HA   . SER A 1 83  ? 10.15800  -31.50600 -9.42200  1.000 17.97000  ? 83  SER A HA   1 
ATOM   1316 H HB2  . SER A 1 83  ? 9.22000   -30.72600 -11.39700 1.000 16.06000  ? 83  SER A HB2  1 
ATOM   1317 H HB3  . SER A 1 83  ? 8.63600   -29.96000 -10.13200 1.000 16.06000  ? 83  SER A HB3  1 
ATOM   1318 H HG   . SER A 1 83  ? 9.14600   -28.49800 -11.60200 1.000 18.11000  ? 83  SER A HG   1 
ATOM   1319 N N    . GLY A 1 84  ? 12.87100  -31.26800 -9.94900  1.000 13.91000  ? 84  GLY A N    1 
ATOM   1320 C CA   . GLY A 1 84  ? 14.03900  -31.76900 -10.64100 1.000 14.00000  ? 84  GLY A CA   1 
ATOM   1321 C C    . GLY A 1 84  ? 14.00300  -33.24200 -10.96700 1.000 15.17000  ? 84  GLY A C    1 
ATOM   1322 O O    . GLY A 1 84  ? 12.94500  -33.87700 -10.98600 1.000 14.33000  ? 84  GLY A O    1 
ATOM   1323 H H    . GLY A 1 84  ? 12.97900  -31.09600 -9.11300  1.000 16.71000  ? 84  GLY A H    1 
ATOM   1324 H HA2  . GLY A 1 84  ? 14.13700  -31.28500 -11.47600 1.000 16.82000  ? 84  GLY A HA2  1 
ATOM   1325 H HA3  . GLY A 1 84  ? 14.82000  -31.60800 -10.08900 1.000 16.82000  ? 84  GLY A HA3  1 
ATOM   1326 N N    . ILE A 1 85  ? 15.18500  -33.82700 -11.24900 1.000 14.84000  ? 85  ILE A N    1 
ATOM   1327 C CA   . ILE A 1 85  ? 15.21200  -35.19100 -11.76700 1.000 15.44000  ? 85  ILE A CA   1 
ATOM   1328 C C    . ILE A 1 85  ? 14.79500  -36.24300 -10.73600 1.000 14.59000  ? 85  ILE A C    1 
ATOM   1329 O O    . ILE A 1 85  ? 14.44900  -37.38300 -11.08700 1.000 15.59000  ? 85  ILE A O    1 
ATOM   1330 C CB   . ILE A 1 85  ? 16.64600  -35.44600 -12.29200 1.000 15.28000  ? 85  ILE A CB   1 
ATOM   1331 C CG1  . ILE A 1 85  ? 16.64000  -36.73200 -13.12900 1.000 16.96000  ? 85  ILE A CG1  1 
ATOM   1332 C CG2  . ILE A 1 85  ? 17.68600  -35.59200 -11.25400 1.000 16.05000  ? 85  ILE A CG2  1 
ATOM   1333 C CD1  . ILE A 1 85  ? 17.77300  -36.74700 -14.17600 1.000 20.19000  ? 85  ILE A CD1  1 
ATOM   1334 H H    . ILE A 1 85  ? 15.95600  -33.45900 -11.14900 1.000 17.82000  ? 85  ILE A H    1 
ATOM   1335 H HA   . ILE A 1 85  ? 14.56500  -35.27900 -12.48500 1.000 18.54000  ? 85  ILE A HA   1 
ATOM   1336 H HB   . ILE A 1 85  ? 16.87400  -34.65300 -12.80200 1.000 18.35000  ? 85  ILE A HB   1 
ATOM   1337 H HG12 . ILE A 1 85  ? 16.75900  -37.49500 -12.54200 1.000 20.37000  ? 85  ILE A HG12 1 
ATOM   1338 H HG13 . ILE A 1 85  ? 15.79400  -36.80300 -13.59800 1.000 20.37000  ? 85  ILE A HG13 1 
ATOM   1339 H HG21 . ILE A 1 85  ? 18.54800  -35.36600 -11.63700 1.000 19.28000  ? 85  ILE A HG21 1 
ATOM   1340 H HG22 . ILE A 1 85  ? 17.48400  -34.99400 -10.51800 1.000 19.28000  ? 85  ILE A HG22 1 
ATOM   1341 H HG23 . ILE A 1 85  ? 17.69400  -36.51000 -10.94200 1.000 19.28000  ? 85  ILE A HG23 1 
ATOM   1342 H HD11 . ILE A 1 85  ? 17.76700  -37.60100 -14.63600 1.000 24.25000  ? 85  ILE A HD11 1 
ATOM   1343 H HD12 . ILE A 1 85  ? 17.62700  -36.02800 -14.81000 1.000 24.25000  ? 85  ILE A HD12 1 
ATOM   1344 H HD13 . ILE A 1 85  ? 18.62200  -36.62200 -13.72400 1.000 24.25000  ? 85  ILE A HD13 1 
ATOM   1345 N N    . GLY A 1 86  ? 14.85900  -35.91600 -9.40800  1.000 14.55000  ? 86  GLY A N    1 
ATOM   1346 C CA   . GLY A 1 86  ? 14.48000  -36.85300 -8.40100  1.000 13.61000  ? 86  GLY A CA   1 
ATOM   1347 C C    . GLY A 1 86  ? 15.55300  -37.89200 -8.17100  1.000 14.27000  ? 86  GLY A C    1 
ATOM   1348 O O    . GLY A 1 86  ? 16.65800  -37.83000 -8.70800  1.000 16.21000  ? 86  GLY A O    1 
ATOM   1349 H H    . GLY A 1 86  ? 15.12100  -35.15500 -9.10500  1.000 17.48000  ? 86  GLY A H    1 
ATOM   1350 H HA2  . GLY A 1 86  ? 14.32100  -36.38500 -7.56700  1.000 16.36000  ? 86  GLY A HA2  1 
ATOM   1351 H HA3  . GLY A 1 86  ? 13.66500  -37.30600 -8.67000  1.000 16.36000  ? 86  GLY A HA3  1 
ATOM   1352 N N    . MET A 1 87  ? 15.23000  -38.82100 -7.29900  1.000 13.80000  ? 87  MET A N    1 
ATOM   1353 C CA   . MET A 1 87  ? 16.10000  -39.91000 -6.84900  1.000 13.16000  ? 87  MET A CA   1 
ATOM   1354 C C    . MET A 1 87  ? 15.29600  -41.18500 -6.72800  1.000 16.28000  ? 87  MET A C    1 
ATOM   1355 O O    . MET A 1 87  ? 14.22400  -41.18700 -6.12700  1.000 16.28000  ? 87  MET A O    1 
ATOM   1356 C CB   . MET A 1 87  ? 16.76900  -39.58000 -5.53000  1.000 15.45000  ? 87  MET A CB   1 
ATOM   1357 C CG   . MET A 1 87  ? 17.73000  -38.41000 -5.58300  1.000 16.18000  ? 87  MET A CG   1 
ATOM   1358 S SD   . MET A 1 87  ? 18.31100  -37.78200 -3.99900  1.000 17.41000  ? 87  MET A SD   1 
ATOM   1359 C CE   . MET A 1 87  ? 16.83600  -36.92900 -3.40000  1.000 17.73000  ? 87  MET A CE   1 
ATOM   1360 H H    . MET A 1 87  ? 14.45800  -38.85400 -6.92000  1.000 16.58000  ? 87  MET A H    1 
ATOM   1361 H HA   . MET A 1 87  ? 16.79800  -40.04400 -7.51000  1.000 15.81000  ? 87  MET A HA   1 
ATOM   1362 H HB2  . MET A 1 87  ? 16.08100  -39.36300 -4.88100  1.000 18.56000  ? 87  MET A HB2  1 
ATOM   1363 H HB3  . MET A 1 87  ? 17.27000  -40.35600 -5.23500  1.000 18.56000  ? 87  MET A HB3  1 
ATOM   1364 H HG2  . MET A 1 87  ? 18.51300  -38.68400 -6.08500  1.000 19.44000  ? 87  MET A HG2  1 
ATOM   1365 H HG3  . MET A 1 87  ? 17.28700  -37.67500 -6.03500  1.000 19.44000  ? 87  MET A HG3  1 
ATOM   1366 H HE1  . MET A 1 87  ? 17.02900  -36.53200 -2.53700  1.000 21.29000  ? 87  MET A HE1  1 
ATOM   1367 H HE2  . MET A 1 87  ? 16.59100  -36.23800 -4.03500  1.000 21.29000  ? 87  MET A HE2  1 
ATOM   1368 H HE3  . MET A 1 87  ? 16.11300  -37.57000 -3.31500  1.000 21.29000  ? 87  MET A HE3  1 
ATOM   1369 N N    . THR A 1 88  ? 15.82300  -42.26400 -7.29800  1.000 16.63000  ? 88  THR A N    1 
ATOM   1370 C CA   . THR A 1 88  ? 15.24200  -43.58700 -7.12300  1.000 16.50000  ? 88  THR A CA   1 
ATOM   1371 C C    . THR A 1 88  ? 15.51000  -44.08400 -5.70800  1.000 16.83000  ? 88  THR A C    1 
ATOM   1372 O O    . THR A 1 88  ? 16.29400  -43.52700 -4.95000  1.000 17.35000  ? 88  THR A O    1 
ATOM   1373 C CB   . THR A 1 88  ? 15.85700  -44.60300 -8.11100  1.000 16.90000  ? 88  THR A CB   1 
ATOM   1374 O OG1  . THR A 1 88  ? 17.23400  -44.73200 -7.78500  1.000 19.06000  ? 88  THR A OG1  1 
ATOM   1375 C CG2  . THR A 1 88  ? 15.70700  -44.14500 -9.50600  1.000 20.69000  ? 88  THR A CG2  1 
ATOM   1376 H H    . THR A 1 88  ? 16.52500  -42.25500 -7.79500  1.000 19.98000  ? 88  THR A H    1 
ATOM   1377 H HA   . THR A 1 88  ? 14.28800  -43.52600 -7.28700  1.000 19.82000  ? 88  THR A HA   1 
ATOM   1378 H HB   . THR A 1 88  ? 15.40800  -45.46100 -8.04700  1.000 20.30000  ? 88  THR A HB   1 
ATOM   1379 H HG1  . THR A 1 88  ? 17.37600  -45.47600 -7.42300  1.000 22.89000  ? 88  THR A HG1  1 
ATOM   1380 H HG21 . THR A 1 88  ? 15.88800  -44.87600 -10.11700 1.000 24.85000  ? 88  THR A HG21 1 
ATOM   1381 H HG22 . THR A 1 88  ? 14.80300  -43.82700 -9.65600  1.000 24.85000  ? 88  THR A HG22 1 
ATOM   1382 H HG23 . THR A 1 88  ? 16.32900  -43.42200 -9.68700  1.000 24.85000  ? 88  THR A HG23 1 
ATOM   1383 N N    . LYS A 1 89  ? 14.87900  -45.19400 -5.34000  1.000 18.02000  ? 89  LYS A N    1 
ATOM   1384 C CA   . LYS A 1 89  ? 15.18900  -45.82600 -4.06100  1.000 18.31000  ? 89  LYS A CA   1 
ATOM   1385 C C    . LYS A 1 89  ? 16.69000  -46.04000 -3.92900  1.000 18.95000  ? 89  LYS A C    1 
ATOM   1386 O O    . LYS A 1 89  ? 17.29000  -45.71100 -2.91900  1.000 19.15000  ? 89  LYS A O    1 
ATOM   1387 C CB   . LYS A 1 89  ? 14.45800  -47.18600 -3.89800  1.000 20.79000  ? 89  LYS A CB   1 
ATOM   1388 C CG   . LYS A 1 89  ? 14.74000  -47.83700 -2.52500  1.000 20.33000  ? 89  LYS A CG   1 
ATOM   1389 C CD   . LYS A 1 89  ? 14.14100  -49.27300 -2.52300  1.000 25.00000  ? 89  LYS A CD   1 
ATOM   1390 C CE   . LYS A 1 89  ? 14.48800  -49.91100 -1.21000  1.000 33.58000  ? 89  LYS A CE   1 
ATOM   1391 N NZ   . LYS A 1 89  ? 13.78100  -51.24100 -1.07700  1.000 40.14000  ? 89  LYS A NZ   1 
ATOM   1392 H H    . LYS A 1 89  ? 14.27700  -45.59600 -5.80500  1.000 21.64000  ? 89  LYS A H    1 
ATOM   1393 H HA   . LYS A 1 89  ? 14.87000  -45.24000 -3.35700  1.000 21.99000  ? 89  LYS A HA   1 
ATOM   1394 H HB2  . LYS A 1 89  ? 13.50100  -47.04400 -3.97500  1.000 24.97000  ? 89  LYS A HB2  1 
ATOM   1395 H HB3  . LYS A 1 89  ? 14.76000  -47.79400 -4.59000  1.000 24.97000  ? 89  LYS A HB3  1 
ATOM   1396 H HG2  . LYS A 1 89  ? 15.69700  -47.89300 -2.37400  1.000 24.42000  ? 89  LYS A HG2  1 
ATOM   1397 H HG3  . LYS A 1 89  ? 14.32200  -47.31900 -1.82000  1.000 24.42000  ? 89  LYS A HG3  1 
ATOM   1398 H HD2  . LYS A 1 89  ? 13.17600  -49.23400 -2.61600  1.000 30.02000  ? 89  LYS A HD2  1 
ATOM   1399 H HD3  . LYS A 1 89  ? 14.52300  -49.79700 -3.24500  1.000 30.02000  ? 89  LYS A HD3  1 
ATOM   1400 H HE2  . LYS A 1 89  ? 15.44500  -50.06200 -1.16300  1.000 40.31000  ? 89  LYS A HE2  1 
ATOM   1401 H HE3  . LYS A 1 89  ? 14.20600  -49.33500 -0.48300  1.000 40.31000  ? 89  LYS A HE3  1 
ATOM   1402 H HZ1  . LYS A 1 89  ? 14.37400  -51.90500 -1.10100  1.000 48.19000  ? 89  LYS A HZ1  1 
ATOM   1403 H HZ2  . LYS A 1 89  ? 13.34000  -51.27500 -0.30400  1.000 48.19000  ? 89  LYS A HZ2  1 
ATOM   1404 H HZ3  . LYS A 1 89  ? 13.20200  -51.34700 -1.74400  1.000 48.19000  ? 89  LYS A HZ3  1 
ATOM   1405 N N    . ALA A 1 90  ? 17.28700  -46.63200 -4.95400  1.000 19.43000  ? 90  ALA A N    1 
ATOM   1406 C CA   . ALA A 1 90  ? 18.70900  -46.90800 -4.88300  1.000 21.60000  ? 90  ALA A CA   1 
ATOM   1407 C C    . ALA A 1 90  ? 19.55100  -45.64300 -4.75000  1.000 20.03000  ? 90  ALA A C    1 
ATOM   1408 O O    . ALA A 1 90  ? 20.58700  -45.64900 -4.06700  1.000 22.27000  ? 90  ALA A O    1 
ATOM   1409 C CB   . ALA A 1 90  ? 19.12300  -47.72200 -6.10400  1.000 26.33000  ? 90  ALA A CB   1 
ATOM   1410 H H    . ALA A 1 90  ? 16.90000  -46.87700 -5.68200  1.000 23.34000  ? 90  ALA A H    1 
ATOM   1411 H HA   . ALA A 1 90  ? 18.88200  -47.43200 -4.08500  1.000 25.94000  ? 90  ALA A HA   1 
ATOM   1412 H HB1  . ALA A 1 90  ? 20.02900  -48.04200 -5.97700  1.000 31.62000  ? 90  ALA A HB1  1 
ATOM   1413 H HB2  . ALA A 1 90  ? 18.51700  -48.47300 -6.20200  1.000 31.62000  ? 90  ALA A HB2  1 
ATOM   1414 H HB3  . ALA A 1 90  ? 19.07800  -47.15600 -6.89000  1.000 31.62000  ? 90  ALA A HB3  1 
ATOM   1415 N N    . ASP A 1 91  ? 19.15100  -44.57100 -5.43200  1.000 18.84000  ? 91  ASP A N    1 
ATOM   1416 C CA   . ASP A 1 91  ? 19.83000  -43.27800 -5.34000  1.000 18.58000  ? 91  ASP A CA   1 
ATOM   1417 C C    . ASP A 1 91  ? 19.76100  -42.78400 -3.89200  1.000 24.29000  ? 91  ASP A C    1 
ATOM   1418 O O    . ASP A 1 91  ? 20.72100  -42.22700 -3.35700  1.000 23.11000  ? 91  ASP A O    1 
ATOM   1419 C CB   . ASP A 1 91  ? 19.19500  -42.22500 -6.23800  1.000 19.28000  ? 91  ASP A CB   1 
ATOM   1420 C CG   . ASP A 1 91  ? 19.41400  -42.40000 -7.73100  1.000 22.45000  ? 91  ASP A CG   1 
ATOM   1421 O OD1  . ASP A 1 91  ? 20.43200  -43.06900 -8.11900  1.000 26.44000  ? 91  ASP A OD1  1 
ATOM   1422 O OD2  . ASP A 1 91  ? 18.53400  -41.92800 -8.56500  1.000 20.20000  ? 91  ASP A OD2  1 
ATOM   1423 H H    . ASP A 1 91  ? 18.47700  -44.56300 -5.96600  1.000 22.63000  ? 91  ASP A H    1 
ATOM   1424 H HA   . ASP A 1 91  ? 20.74500  -43.39600 -5.63800  1.000 22.31000  ? 91  ASP A HA   1 
ATOM   1425 H HB2  . ASP A 1 91  ? 18.23700  -42.23500 -6.08700  1.000 23.16000  ? 91  ASP A HB2  1 
ATOM   1426 H HB3  . ASP A 1 91  ? 19.56000  -41.35900 -5.99600  1.000 23.16000  ? 91  ASP A HB3  1 
ATOM   1427 N N    . LEU A 1 92  ? 18.60200  -42.91100 -3.25400  1.000 19.55000  ? 92  LEU A N    1 
ATOM   1428 C CA   . LEU A 1 92  ? 18.44600  -42.38400 -1.87600  1.000 20.87000  ? 92  LEU A CA   1 
ATOM   1429 C C    . LEU A 1 92  ? 19.38600  -43.15100 -0.94200  1.000 23.17000  ? 92  LEU A C    1 
ATOM   1430 O O    . LEU A 1 92  ? 20.06500  -42.53600 -0.14100  1.000 27.73000  ? 92  LEU A O    1 
ATOM   1431 C CB   . LEU A 1 92  ? 16.99200  -42.48900 -1.41700  1.000 19.22000  ? 92  LEU A CB   1 
ATOM   1432 C CG   . LEU A 1 92  ? 16.01500  -41.52300 -2.08800  1.000 18.62000  ? 92  LEU A CG   1 
ATOM   1433 C CD1  . LEU A 1 92  ? 14.59400  -41.97800 -1.83400  1.000 17.13000  ? 92  LEU A CD1  1 
ATOM   1434 C CD2  . LEU A 1 92  ? 16.23400  -40.10900 -1.59100  1.000 19.60000  ? 92  LEU A CD2  1 
ATOM   1435 H H    . LEU A 1 92  ? 17.88500  -43.32400 -3.61500  1.000 23.48000  ? 92  LEU A H    1 
ATOM   1436 H HA   . LEU A 1 92  ? 18.71500  -41.43100 -1.87500  1.000 25.07000  ? 92  LEU A HA   1 
ATOM   1437 H HB2  . LEU A 1 92  ? 16.68300  -43.40800 -1.58400  1.000 23.09000  ? 92  LEU A HB2  1 
ATOM   1438 H HB3  . LEU A 1 92  ? 16.96500  -42.33300 -0.44400  1.000 23.09000  ? 92  LEU A HB3  1 
ATOM   1439 H HG   . LEU A 1 92  ? 16.18000  -41.54000 -3.06500  1.000 22.36000  ? 92  LEU A HG   1 
ATOM   1440 H HD11 . LEU A 1 92  ? 13.97500  -41.35900 -2.25600  1.000 20.57000  ? 92  LEU A HD11 1 
ATOM   1441 H HD12 . LEU A 1 92  ? 14.46700  -42.86800 -2.20500  1.000 20.57000  ? 92  LEU A HD12 1 
ATOM   1442 H HD13 . LEU A 1 92  ? 14.42800  -42.00000 -0.87600  1.000 20.57000  ? 92  LEU A HD13 1 
ATOM   1443 H HD21 . LEU A 1 92  ? 16.32300  -40.11500 -0.62200  1.000 23.54000  ? 92  LEU A HD21 1 
ATOM   1444 H HD22 . LEU A 1 92  ? 17.04500  -39.74800 -1.98700  1.000 23.54000  ? 92  LEU A HD22 1 
ATOM   1445 H HD23 . LEU A 1 92  ? 15.47600  -39.55500 -1.84400  1.000 23.54000  ? 92  LEU A HD23 1 
ATOM   1446 N N    . VAL A 1 93  ? 19.41000  -44.46100 -1.06100  1.000 22.95000  ? 93  VAL A N    1 
ATOM   1447 C CA   . VAL A 1 93  ? 20.28500  -45.29400 -0.19200  1.000 23.53000  ? 93  VAL A CA   1 
ATOM   1448 C C    . VAL A 1 93  ? 21.75600  -44.97600 -0.50900  1.000 31.22000  ? 93  VAL A C    1 
ATOM   1449 O O    . VAL A 1 93  ? 22.49300  -44.74000 0.44500   1.000 37.16000  ? 93  VAL A O    1 
ATOM   1450 C CB   . VAL A 1 93  ? 19.94500  -46.77800 -0.39100  1.000 23.50000  ? 93  VAL A CB   1 
ATOM   1451 C CG1  . VAL A 1 93  ? 20.97300  -47.68200 0.27400   1.000 29.47000  ? 93  VAL A CG1  1 
ATOM   1452 C CG2  . VAL A 1 93  ? 18.55100  -47.11500 0.11700   1.000 24.77000  ? 93  VAL A CG2  1 
ATOM   1453 H H    . VAL A 1 93  ? 18.91500  -44.89400 -1.67800  1.000 27.56000  ? 93  VAL A H    1 
ATOM   1454 H HA   . VAL A 1 93  ? 20.10800  -45.06000 0.74000   1.000 28.25000  ? 93  VAL A HA   1 
ATOM   1455 H HB   . VAL A 1 93  ? 19.96500  -46.95200 -1.36100  1.000 28.21000  ? 93  VAL A HB   1 
ATOM   1456 H HG11 . VAL A 1 93  ? 21.25800  -47.28600 1.11500   1.000 35.39000  ? 93  VAL A HG11 1 
ATOM   1457 H HG12 . VAL A 1 93  ? 20.57400  -48.55100 0.44600   1.000 35.39000  ? 93  VAL A HG12 1 
ATOM   1458 H HG13 . VAL A 1 93  ? 21.74200  -47.78900 -0.31200  1.000 35.39000  ? 93  VAL A HG13 1 
ATOM   1459 H HG21 . VAL A 1 93  ? 18.33700  -48.03500 -0.10900  1.000 29.74000  ? 93  VAL A HG21 1 
ATOM   1460 H HG22 . VAL A 1 93  ? 18.52400  -47.00500 1.08300   1.000 29.74000  ? 93  VAL A HG22 1 
ATOM   1461 H HG23 . VAL A 1 93  ? 17.90100  -46.52100 -0.29300  1.000 29.74000  ? 93  VAL A HG23 1 
ATOM   1462 N N    . ASN A 1 94  ? 22.12500  -44.87100 -1.77900  1.000 30.57000  ? 94  ASN A N    1 
ATOM   1463 C CA   . ASN A 1 94  ? 23.52600  -44.65600 -2.21600  1.000 32.38000  ? 94  ASN A CA   1 
ATOM   1464 C C    . ASN A 1 94  ? 24.03400  -43.24800 -1.93800  1.000 33.61000  ? 94  ASN A C    1 
ATOM   1465 O O    . ASN A 1 94  ? 25.13400  -43.13300 -1.40600  1.000 41.74000  ? 94  ASN A O    1 
ATOM   1466 C CB   . ASN A 1 94  ? 23.64500  -44.88500 -3.71400  1.000 34.02000  ? 94  ASN A CB   1 
ATOM   1467 C CG   . ASN A 1 94  ? 25.04100  -44.65700 -4.23300  1.000 34.15000  ? 94  ASN A CG   1 
ATOM   1468 O OD1  . ASN A 1 94  ? 25.95300  -45.42100 -3.90900  1.000 44.04000  ? 94  ASN A OD1  1 
ATOM   1469 N ND2  . ASN A 1 94  ? 25.22000  -43.62600 -5.04200  1.000 29.82000  ? 94  ASN A ND2  1 
ATOM   1470 H H    . ASN A 1 94  ? 21.52800  -44.90500 -2.45300  1.000 36.71000  ? 94  ASN A H    1 
ATOM   1471 H HA   . ASN A 1 94  ? 24.10400  -45.30600 -1.76500  1.000 38.87000  ? 94  ASN A HA   1 
ATOM   1472 H HB2  . ASN A 1 94  ? 23.37600  -45.80000 -3.91800  1.000 40.84000  ? 94  ASN A HB2  1 
ATOM   1473 H HB3  . ASN A 1 94  ? 23.03000  -44.28000 -4.17600  1.000 40.84000  ? 94  ASN A HB3  1 
ATOM   1474 H HD21 . ASN A 1 94  ? 25.82800  -43.66500 -5.68500  1.000 35.80000  ? 94  ASN A HD21 1 
ATOM   1475 H HD22 . ASN A 1 94  ? 24.72600  -42.89500 -4.93500  1.000 35.80000  ? 94  ASN A HD22 1 
ATOM   1476 N N    . ASN A 1 95  ? 23.29900  -42.22600 -2.33400  1.000 32.78000  ? 95  ASN A N    1 
ATOM   1477 C CA   . ASN A 1 95  ? 23.79600  -40.83500 -2.23000  1.000 31.06000  ? 95  ASN A CA   1 
ATOM   1478 C C    . ASN A 1 95  ? 23.58900  -40.23900 -0.85100  1.000 29.10000  ? 95  ASN A C    1 
ATOM   1479 O O    . ASN A 1 95  ? 24.35100  -39.33700 -0.55100  1.000 32.83000  ? 95  ASN A O    1 
ATOM   1480 C CB   . ASN A 1 95  ? 23.04300  -39.81800 -3.07000  1.000 44.32000  ? 95  ASN A CB   1 
ATOM   1481 C CG   . ASN A 1 95  ? 22.77700  -40.25500 -4.48400  1.000 56.96000  ? 95  ASN A CG   1 
ATOM   1482 O OD1  . ASN A 1 95  ? 23.61300  -40.90700 -5.11600  1.000 55.00000  ? 95  ASN A OD1  1 
ATOM   1483 N ND2  . ASN A 1 95  ? 21.61300  -39.88400 -4.98700  1.000 48.34000  ? 95  ASN A ND2  1 
ATOM   1484 H H    . ASN A 1 95  ? 22.46800  -42.34600 -2.65600  1.000 39.35000  ? 95  ASN A H    1 
ATOM   1485 H HA   . ASN A 1 95  ? 24.74700  -40.80200 -2.47600  1.000 37.29000  ? 95  ASN A HA   1 
ATOM   1486 H HB2  . ASN A 1 95  ? 22.18700  -39.62800 -2.63500  1.000 53.20000  ? 95  ASN A HB2  1 
ATOM   1487 H HB3  . ASN A 1 95  ? 23.55500  -38.98500 -3.09100  1.000 53.20000  ? 95  ASN A HB3  1 
ATOM   1488 H HD21 . ASN A 1 95  ? 21.10700  -39.29800 -4.55400  1.000 58.03000  ? 95  ASN A HD21 1 
ATOM   1489 H HD22 . ASN A 1 95  ? 21.33900  -40.22900 -5.75400  1.000 58.03000  ? 95  ASN A HD22 1 
ATOM   1490 N N    . LEU A 1 96  ? 22.61800  -40.72100 -0.07300  1.000 26.91000  ? 96  LEU A N    1 
ATOM   1491 C CA   . LEU A 1 96  ? 22.26500  -40.04700 1.20500   1.000 34.59000  ? 96  LEU A CA   1 
ATOM   1492 C C    . LEU A 1 96  ? 22.66000  -40.86200 2.43300   1.000 52.13000  ? 96  LEU A C    1 
ATOM   1493 O O    . LEU A 1 96  ? 21.85200  -40.89900 3.37000   1.000 38.99000  ? 96  LEU A O    1 
ATOM   1494 C CB   . LEU A 1 96  ? 20.77300  -39.70300 1.26600   1.000 29.20000  ? 96  LEU A CB   1 
ATOM   1495 C CG   . LEU A 1 96  ? 20.22000  -38.77100 0.19000   1.000 29.32000  ? 96  LEU A CG   1 
ATOM   1496 C CD1  . LEU A 1 96  ? 18.79200  -38.44800 0.58300   1.000 23.75000  ? 96  LEU A CD1  1 
ATOM   1497 C CD2  . LEU A 1 96  ? 21.04500  -37.50700 0.05100   1.000 30.68000  ? 96  LEU A CD2  1 
ATOM   1498 H H    . LEU A 1 96  ? 22.15000  -41.46000 -0.29200  1.000 32.31000  ? 96  LEU A H    1 
ATOM   1499 H HA   . LEU A 1 96  ? 22.77200  -39.20300 1.25500   1.000 41.53000  ? 96  LEU A HA   1 
ATOM   1500 H HB2  . LEU A 1 96  ? 20.25700  -40.53800 1.25000   1.000 35.06000  ? 96  LEU A HB2  1 
ATOM   1501 H HB3  . LEU A 1 96  ? 20.59200  -39.27400 2.13300   1.000 35.06000  ? 96  LEU A HB3  1 
ATOM   1502 H HG   . LEU A 1 96  ? 20.21600  -39.25300 -0.67700  1.000 35.20000  ? 96  LEU A HG   1 
ATOM   1503 H HD11 . LEU A 1 96  ? 18.78800  -37.98000 1.43500   1.000 28.52000  ? 96  LEU A HD11 1 
ATOM   1504 H HD12 . LEU A 1 96  ? 18.38700  -37.88400 -0.09800  1.000 28.52000  ? 96  LEU A HD12 1 
ATOM   1505 H HD13 . LEU A 1 96  ? 18.28300  -39.27300 0.66500   1.000 28.52000  ? 96  LEU A HD13 1 
ATOM   1506 H HD21 . LEU A 1 96  ? 21.23600  -37.14400 0.93200   1.000 36.84000  ? 96  LEU A HD21 1 
ATOM   1507 H HD22 . LEU A 1 96  ? 21.87900  -37.71200 -0.40400  1.000 36.84000  ? 96  LEU A HD22 1 
ATOM   1508 H HD23 . LEU A 1 96  ? 20.54900  -36.85400 -0.46700  1.000 36.84000  ? 96  LEU A HD23 1 
ATOM   1509 N N    . GLY A 1 97  ? 23.80600  -41.53300 2.44500   1.000 33.62000  ? 97  GLY A N    1 
ATOM   1510 C CA   . GLY A 1 97  ? 24.22600  -42.09800 3.70800   1.000 46.66000  ? 97  GLY A CA   1 
ATOM   1511 C C    . GLY A 1 97  ? 25.16000  -43.27900 3.69400   1.000 48.96000  ? 97  GLY A C    1 
ATOM   1512 O O    . GLY A 1 97  ? 26.04700  -43.31600 4.54700   1.000 40.03000  ? 97  GLY A O    1 
ATOM   1513 H H    . GLY A 1 97  ? 24.32300  -41.64600 1.76800   1.000 40.36000  ? 97  GLY A H    1 
ATOM   1514 H HA2  . GLY A 1 97  ? 24.66800  -41.39800 4.21400   1.000 56.01000  ? 97  GLY A HA2  1 
ATOM   1515 H HA3  . GLY A 1 97  ? 23.43000  -42.37800 4.18700   1.000 56.01000  ? 97  GLY A HA3  1 
ATOM   1516 N N    . THR A 1 98  ? 24.91800  -44.27800 2.86700   1.000 39.98000  ? 98  THR A N    1 
ATOM   1517 C CA   . THR A 1 98  ? 25.63700  -45.56500 2.93300   1.000 48.27000  ? 98  THR A CA   1 
ATOM   1518 C C    . THR A 1 98  ? 27.02000  -45.51700 2.33800   1.000 49.91000  ? 98  THR A C    1 
ATOM   1519 O O    . THR A 1 98  ? 27.83100  -46.36100 2.75800   1.000 47.69000  ? 98  THR A O    1 
ATOM   1520 C CB   . THR A 1 98  ? 24.76100  -46.55800 2.18500   1.000 49.08000  ? 98  THR A CB   1 
ATOM   1521 O OG1  . THR A 1 98  ? 25.33100  -47.84000 2.42000   1.000 58.80000  ? 98  THR A OG1  1 
ATOM   1522 C CG2  . THR A 1 98  ? 24.76000  -46.20500 0.71700   1.000 38.15000  ? 98  THR A CG2  1 
ATOM   1523 H H    . THR A 1 98  ? 24.28200  -44.25600 2.22800   1.000 48.00000  ? 98  THR A H    1 
ATOM   1524 H HA   . THR A 1 98  ? 25.70100  -45.84400 3.87200   1.000 57.95000  ? 98  THR A HA   1 
ATOM   1525 N N    . ILE A 1 99  ? 27.25500  -44.66900 1.34500   1.000 47.60000  ? 99  ILE A N    1 
ATOM   1526 C CA   . ILE A 1 99  ? 28.55500  -44.61500 0.62300   1.000 53.09000  ? 99  ILE A CA   1 
ATOM   1527 C C    . ILE A 1 99  ? 29.31400  -43.35600 1.05400   1.000 65.26000  ? 99  ILE A C    1 
ATOM   1528 O O    . ILE A 1 99  ? 28.77900  -42.25000 0.92700   1.000 41.48000  ? 99  ILE A O    1 
ATOM   1529 C CB   . ILE A 1 99  ? 28.33300  -44.68100 -0.89500  1.000 45.98000  ? 99  ILE A CB   1 
ATOM   1530 C CG1  . ILE A 1 99  ? 27.30800  -45.73900 -1.25600  1.000 53.51000  ? 99  ILE A CG1  1 
ATOM   1531 C CG2  . ILE A 1 99  ? 29.65500  -44.91400 -1.62300  1.000 66.10000  ? 99  ILE A CG2  1 
ATOM   1532 C CD1  . ILE A 1 99  ? 27.86300  -47.14900 -1.27700  1.000 56.45000  ? 99  ILE A CD1  1 
ATOM   1533 H H    . ILE A 1 99  ? 26.62300  -44.10000 1.05400   1.000 57.14000  ? 99  ILE A H    1 
ATOM   1534 H HA   . ILE A 1 99  ? 29.08500  -45.38900 0.88000   1.000 63.73000  ? 99  ILE A HA   1 
ATOM   1535 N N    . ALA A 1 100 ? 30.54000  -43.56100 1.52800   1.000 67.92000  ? 100 ALA A N    1 
ATOM   1536 C CA   . ALA A 1 100 ? 31.33100  -42.42600 2.03100   1.000 71.97000  ? 100 ALA A CA   1 
ATOM   1537 C C    . ALA A 1 100 ? 31.49100  -41.39900 0.92800   1.000 66.31000  ? 100 ALA A C    1 
ATOM   1538 O O    . ALA A 1 100 ? 31.84300  -41.80600 -0.19500  1.000 78.59000  ? 100 ALA A O    1 
ATOM   1539 C CB   . ALA A 1 100 ? 32.68200  -42.91200 2.51500   1.000 72.82000  ? 100 ALA A CB   1 
ATOM   1540 N N    . LYS A 1 101 ? 31.18500  -40.14300 1.22300   1.000 62.32000  ? 101 LYS A N    1 
ATOM   1541 C CA   . LYS A 1 101 ? 31.46900  -39.07200 0.25100   1.000 69.22000  ? 101 LYS A CA   1 
ATOM   1542 C C    . LYS A 1 101 ? 32.80700  -38.50800 0.74500   1.000 63.71000  ? 101 LYS A C    1 
ATOM   1543 O O    . LYS A 1 101 ? 32.99400  -38.45000 1.96900   1.000 62.24000  ? 101 LYS A O    1 
ATOM   1544 C CB   . LYS A 1 101 ? 30.33400  -38.05200 0.11300   1.000 52.15000  ? 101 LYS A CB   1 
ATOM   1545 H H    . LYS A 1 101 ? 30.80700  -39.91200 2.00900   1.000 74.80000  ? 101 LYS A H    1 
ATOM   1546 H HA   . LYS A 1 101 ? 31.61400  -39.47100 -0.64000  1.000 83.08000  ? 101 LYS A HA   1 
ATOM   1547 N N    . SER A 1 102 ? 33.75600  -38.34100 -0.13800  1.000 46.06000  ? 102 SER A N    1 
ATOM   1548 C CA   . SER A 1 102 ? 35.04800  -37.70200 0.18100   1.000 71.99000  ? 102 SER A CA   1 
ATOM   1549 C C    . SER A 1 102 ? 34.76200  -36.36200 0.83000   1.000 71.78000  ? 102 SER A C    1 
ATOM   1550 O O    . SER A 1 102 ? 35.51100  -35.93900 1.71100   1.000 68.00000  ? 102 SER A O    1 
ATOM   1551 C CB   . SER A 1 102 ? 35.79100  -37.52800 -1.09100  1.000 53.49000  ? 102 SER A CB   1 
ATOM   1552 O OG   . SER A 1 102 ? 34.89200  -37.42700 -2.18200  1.000 56.90000  ? 102 SER A OG   1 
ATOM   1553 H H    . SER A 1 102 ? 33.70700  -38.69600 -1.10900  1.000 55.29000  ? 102 SER A H    1 
ATOM   1554 H HA   . SER A 1 102 ? 35.61200  -38.33400 0.86500   1.000 86.41000  ? 102 SER A HA   1 
ATOM   1555 H HB2  . SER A 1 102 ? 36.39800  -36.62600 -1.03300  1.000 64.21000  ? 102 SER A HB2  1 
ATOM   1556 H HB3  . SER A 1 102 ? 36.45500  -38.37800 -1.24200  1.000 64.21000  ? 102 SER A HB3  1 
ATOM   1557 H HG   . SER A 1 102 ? 34.37500  -36.61400 -2.07500  1.000 68.29000  ? 102 SER A HG   1 
ATOM   1558 N N    . GLY A 1 103 ? 33.71000  -35.70600 0.36800   1.000 62.23000  ? 103 GLY A N    1 
ATOM   1559 C CA   . GLY A 1 103 ? 33.38000  -34.36700 0.86400   1.000 59.20000  ? 103 GLY A CA   1 
ATOM   1560 C C    . GLY A 1 103 ? 33.37100  -34.30900 2.36700   1.000 55.04000  ? 103 GLY A C    1 
ATOM   1561 O O    . GLY A 1 103 ? 33.81000  -33.28300 2.88400   1.000 45.67000  ? 103 GLY A O    1 
ATOM   1562 H H    . GLY A 1 103 ? 33.08000  -36.08100 -0.36300  1.000 74.70000  ? 103 GLY A H    1 
ATOM   1563 H HA2  . GLY A 1 103 ? 34.10300  -33.65100 0.47600   1.000 71.06000  ? 103 GLY A HA2  1 
ATOM   1564 H HA3  . GLY A 1 103 ? 32.39300  -34.09500 0.49400   1.000 71.06000  ? 103 GLY A HA3  1 
ATOM   1565 N N    . THR A 1 104 ? 32.87700  -35.34300 3.03600   1.000 48.08000  ? 104 THR A N    1 
ATOM   1566 C CA   . THR A 1 104 ? 32.69400  -35.33200 4.50000   1.000 47.27000  ? 104 THR A CA   1 
ATOM   1567 C C    . THR A 1 104 ? 34.03800  -35.12200 5.19200   1.000 42.09000  ? 104 THR A C    1 
ATOM   1568 O O    . THR A 1 104 ? 34.10800  -34.15900 5.91500   1.000 32.11000  ? 104 THR A O    1 
ATOM   1569 C CB   . THR A 1 104 ? 31.94100  -36.58700 4.97000   1.000 31.59000  ? 104 THR A CB   1 
ATOM   1570 O OG1  . THR A 1 104 ? 31.11100  -37.02900 3.89900   1.000 61.28000  ? 104 THR A OG1  1 
ATOM   1571 C CG2  . THR A 1 104 ? 31.10100  -36.33400 6.19700   1.000 44.61000  ? 104 THR A CG2  1 
ATOM   1572 H H    . THR A 1 104 ? 32.57900  -36.23200 2.59600   1.000 57.72000  ? 104 THR A H    1 
ATOM   1573 H HA   . THR A 1 104 ? 32.07100  -34.46900 4.73200   1.000 56.74000  ? 104 THR A HA   1 
ATOM   1574 H HB   . THR A 1 104 ? 32.67200  -37.36200 5.19500   1.000 37.93000  ? 104 THR A HB   1 
ATOM   1575 H HG1  . THR A 1 104 ? 30.70400  -37.87800 4.13400   1.000 73.56000  ? 104 THR A HG1  1 
ATOM   1576 H HG21 . THR A 1 104 ? 30.16400  -36.88300 6.11700   1.000 53.55000  ? 104 THR A HG21 1 
ATOM   1577 H HG22 . THR A 1 104 ? 31.64400  -36.66800 7.07600   1.000 53.55000  ? 104 THR A HG22 1 
ATOM   1578 H HG23 . THR A 1 104 ? 30.89300  -35.27000 6.28500   1.000 53.55000  ? 104 THR A HG23 1 
ATOM   1579 N N    . LYS A 1 105 ? 35.07600  -35.92600 4.93700   1.000 36.91000  ? 105 LYS A N    1 
ATOM   1580 C CA   . LYS A 1 105 ? 36.31600  -35.86800 5.70200   1.000 38.47000  ? 105 LYS A CA   1 
ATOM   1581 C C    . LYS A 1 105 ? 37.04700  -34.55300 5.45300   1.000 29.14000  ? 105 LYS A C    1 
ATOM   1582 O O    . LYS A 1 105 ? 37.47900  -33.89100 6.39400   1.000 33.42000  ? 105 LYS A O    1 
ATOM   1583 C CB   . LYS A 1 105 ? 37.24000  -37.05400 5.36800   1.000 41.47000  ? 105 LYS A CB   1 
ATOM   1584 H H    . LYS A 1 105 ? 35.07200  -36.52300 4.31900   1.000 44.31000  ? 105 LYS A H    1 
ATOM   1585 H HA   . LYS A 1 105 ? 36.08600  -35.93200 6.64300   1.000 46.18000  ? 105 LYS A HA   1 
ATOM   1586 N N    . SER A 1 106 ? 37.15200  -34.14800 4.18400   1.000 39.44000  ? 106 SER A N    1 
ATOM   1587 C CA   . SER A 1 106 ? 37.84000  -32.90500 3.86000   1.000 36.15000  ? 106 SER A CA   1 
ATOM   1588 C C    . SER A 1 106 ? 37.15000  -31.71300 4.52200   1.000 30.95000  ? 106 SER A C    1 
ATOM   1589 O O    . SER A 1 106 ? 37.80600  -30.77500 4.99700   1.000 28.73000  ? 106 SER A O    1 
ATOM   1590 C CB   . SER A 1 106 ? 37.88100  -32.70400 2.34400   1.000 45.64000  ? 106 SER A CB   1 
ATOM   1591 O OG   . SER A 1 106 ? 39.07700  -33.23300 1.80600   1.000 56.65000  ? 106 SER A OG   1 
ATOM   1592 H H    . SER A 1 106 ? 36.83800  -34.57100 3.50400   1.000 47.35000  ? 106 SER A H    1 
ATOM   1593 H HA   . SER A 1 106 ? 38.75200  -32.95900 4.18600   1.000 43.39000  ? 106 SER A HA   1 
ATOM   1594 H HB2  . SER A 1 106 ? 37.12400  -33.16000 1.94300   1.000 54.79000  ? 106 SER A HB2  1 
ATOM   1595 H HB3  . SER A 1 106 ? 37.83700  -31.75500 2.14800   1.000 54.79000  ? 106 SER A HB3  1 
ATOM   1596 H HG   . SER A 1 106 ? 39.06100  -33.18600 0.96700   1.000 68.00000  ? 106 SER A HG   1 
ATOM   1597 N N    . PHE A 1 107 ? 35.82600  -31.72900 4.53900   1.000 28.20000  ? 107 PHE A N    1 
ATOM   1598 C CA   . PHE A 1 107 ? 35.12800  -30.60300 5.14800   1.000 22.24000  ? 107 PHE A CA   1 
ATOM   1599 C C    . PHE A 1 107 ? 35.35600  -30.56200 6.64500   1.000 21.61000  ? 107 PHE A C    1 
ATOM   1600 O O    . PHE A 1 107 ? 35.51800  -29.48300 7.23000   1.000 21.65000  ? 107 PHE A O    1 
ATOM   1601 C CB   . PHE A 1 107 ? 33.62700  -30.70000 4.86800   1.000 27.54000  ? 107 PHE A CB   1 
ATOM   1602 C CG   . PHE A 1 107 ? 32.81200  -29.61500 5.51200   1.000 23.47000  ? 107 PHE A CG   1 
ATOM   1603 C CD1  . PHE A 1 107 ? 33.10700  -28.30000 5.30300   1.000 22.98000  ? 107 PHE A CD1  1 
ATOM   1604 C CD2  . PHE A 1 107 ? 31.75500  -29.92800 6.32600   1.000 27.15000  ? 107 PHE A CD2  1 
ATOM   1605 C CE1  . PHE A 1 107 ? 32.36400  -27.30300 5.94600   1.000 23.06000  ? 107 PHE A CE1  1 
ATOM   1606 C CE2  . PHE A 1 107 ? 31.01000  -28.91100 6.93400   1.000 25.12000  ? 107 PHE A CE2  1 
ATOM   1607 C CZ   . PHE A 1 107 ? 31.33700  -27.61800 6.69600   1.000 22.48000  ? 107 PHE A CZ   1 
ATOM   1608 H H    . PHE A 1 107 ? 35.32700  -32.35200 4.21800   1.000 33.86000  ? 107 PHE A H    1 
ATOM   1609 H HA   . PHE A 1 107 ? 35.46800  -29.78400 4.75500   1.000 26.71000  ? 107 PHE A HA   1 
ATOM   1610 H HB2  . PHE A 1 107 ? 33.48600  -30.64600 3.91000   1.000 33.06000  ? 107 PHE A HB2  1 
ATOM   1611 H HB3  . PHE A 1 107 ? 33.30300  -31.55100 5.20400   1.000 33.06000  ? 107 PHE A HB3  1 
ATOM   1612 H HD1  . PHE A 1 107 ? 33.80200  -28.06600 4.73100   1.000 27.60000  ? 107 PHE A HD1  1 
ATOM   1613 H HD2  . PHE A 1 107 ? 31.53300  -30.81900 6.47500   1.000 32.60000  ? 107 PHE A HD2  1 
ATOM   1614 H HE1  . PHE A 1 107 ? 32.60200  -26.41000 5.84100   1.000 27.69000  ? 107 PHE A HE1  1 
ATOM   1615 H HE2  . PHE A 1 107 ? 30.29800  -29.12100 7.49400   1.000 30.16000  ? 107 PHE A HE2  1 
ATOM   1616 H HZ   . PHE A 1 107 ? 30.82200  -26.94100 7.07300   1.000 27.00000  ? 107 PHE A HZ   1 
ATOM   1617 N N    . MET A 1 108 ? 35.30600  -31.70800 7.31100   1.000 22.99000  ? 108 MET A N    1 
ATOM   1618 C CA   . MET A 1 108 ? 35.54800  -31.76100 8.75000   1.000 20.95000  ? 108 MET A CA   1 
ATOM   1619 C C    . MET A 1 108 ? 36.96500  -31.30600 9.07600   1.000 23.74000  ? 108 MET A C    1 
ATOM   1620 O O    . MET A 1 108 ? 37.18000  -30.62500 10.07600  1.000 24.92000  ? 108 MET A O    1 
ATOM   1621 C CB   . MET A 1 108 ? 35.30400  -33.17700 9.24400   1.000 26.43000  ? 108 MET A CB   1 
ATOM   1622 C CG   . MET A 1 108 ? 33.88000  -33.61400 8.97500   1.000 29.11000  ? 108 MET A CG   1 
ATOM   1623 S SD   . MET A 1 108 ? 33.28500  -34.93100 10.05800  1.000 30.06000  ? 108 MET A SD   1 
ATOM   1624 C CE   . MET A 1 108 ? 33.62900  -36.29800 9.10000   1.000 37.63000  ? 108 MET A CE   1 
ATOM   1625 H H    . MET A 1 108 ? 35.13500  -32.47200 6.95600   1.000 27.60000  ? 108 MET A H    1 
ATOM   1626 H HA   . MET A 1 108 ? 34.92500  -31.17400 9.20600   1.000 25.16000  ? 108 MET A HA   1 
ATOM   1627 H HB2  . MET A 1 108 ? 35.90400  -33.78500 8.78500   1.000 31.74000  ? 108 MET A HB2  1 
ATOM   1628 H HB3  . MET A 1 108 ? 35.46100  -33.21500 10.20100  1.000 31.74000  ? 108 MET A HB3  1 
ATOM   1629 H HG2  . MET A 1 108 ? 33.29400  -32.85000 9.09300   1.000 34.95000  ? 108 MET A HG2  1 
ATOM   1630 H HG3  . MET A 1 108 ? 33.82300  -33.93700 8.06200   1.000 34.95000  ? 108 MET A HG3  1 
ATOM   1631 H HE1  . MET A 1 108 ? 33.30000  -37.09100 9.55100   1.000 45.17000  ? 108 MET A HE1  1 
ATOM   1632 H HE2  . MET A 1 108 ? 33.18800  -36.20000 8.24100   1.000 45.17000  ? 108 MET A HE2  1 
ATOM   1633 H HE3  . MET A 1 108 ? 34.58800  -36.36200 8.97400   1.000 45.17000  ? 108 MET A HE3  1 
ATOM   1634 N N    . GLU A 1 109 ? 37.92700  -31.66400 8.23200   1.000 25.83000  ? 109 GLU A N    1 
ATOM   1635 C CA   . GLU A 1 109 ? 39.28200  -31.15200 8.46100   1.000 25.64000  ? 109 GLU A CA   1 
ATOM   1636 C C    . GLU A 1 109 ? 39.32700  -29.64900 8.27600   1.000 24.70000  ? 109 GLU A C    1 
ATOM   1637 O O    . GLU A 1 109 ? 39.99200  -28.92600 9.04700   1.000 29.14000  ? 109 GLU A O    1 
ATOM   1638 C CB   . GLU A 1 109 ? 40.23500  -31.83200 7.48900   1.000 29.03000  ? 109 GLU A CB   1 
ATOM   1639 C CG   . GLU A 1 109 ? 40.22800  -33.33900 7.64400   1.000 43.55000  ? 109 GLU A CG   1 
ATOM   1640 C CD   . GLU A 1 109 ? 41.48800  -33.98400 7.11400   1.000 68.75000  ? 109 GLU A CD   1 
ATOM   1641 O OE1  . GLU A 1 109 ? 42.58800  -33.50700 7.46800   1.000 71.50000  ? 109 GLU A OE1  1 
ATOM   1642 O OE2  . GLU A 1 109 ? 41.37400  -34.95500 6.33000   1.000 77.62000  ? 109 GLU A OE2  1 
ATOM   1643 H HA   . GLU A 1 109 ? 39.56000  -31.35300 9.36900   1.000 30.79000  ? 109 GLU A HA   1 
ATOM   1644 H HB2  . GLU A 1 109 ? 39.96900  -31.62000 6.58100   1.000 34.85000  ? 109 GLU A HB2  1 
ATOM   1645 H HB3  . GLU A 1 109 ? 41.13700  -31.51500 7.65400   1.000 34.85000  ? 109 GLU A HB3  1 
ATOM   1646 H HG2  . GLU A 1 109 ? 40.15000  -33.56100 8.58500   1.000 52.28000  ? 109 GLU A HG2  1 
ATOM   1647 H HG3  . GLU A 1 109 ? 39.47500  -33.70500 7.15400   1.000 52.28000  ? 109 GLU A HG3  1 
ATOM   1648 N N    . ALA A 1 110 ? 38.63400  -29.15800 7.25600   1.000 23.63000  ? 110 ALA A N    1 
ATOM   1649 C CA   . ALA A 1 110 ? 38.57300  -27.71700 7.05300   1.000 22.54000  ? 110 ALA A CA   1 
ATOM   1650 C C    . ALA A 1 110 ? 37.97000  -27.03000 8.27400   1.000 29.74000  ? 110 ALA A C    1 
ATOM   1651 O O    . ALA A 1 110 ? 38.46100  -25.98800 8.73400   1.000 22.87000  ? 110 ALA A O    1 
ATOM   1652 C CB   . ALA A 1 110 ? 37.81200  -27.40600 5.78200   1.000 23.17000  ? 110 ALA A CB   1 
ATOM   1653 H H    . ALA A 1 110 ? 38.19900  -29.62600 6.68000   1.000 28.38000  ? 110 ALA A H    1 
ATOM   1654 H HA   . ALA A 1 110 ? 39.46700  -27.36000 6.93400   1.000 27.06000  ? 110 ALA A HA   1 
ATOM   1655 H HB1  . ALA A 1 110 ? 37.83200  -26.44800 5.62800   1.000 27.83000  ? 110 ALA A HB1  1 
ATOM   1656 H HB2  . ALA A 1 110 ? 38.23200  -27.86800 5.04000   1.000 27.83000  ? 110 ALA A HB2  1 
ATOM   1657 H HB3  . ALA A 1 110 ? 36.89500  -27.70500 5.88200   1.000 27.83000  ? 110 ALA A HB3  1 
ATOM   1658 N N    . LEU A 1 111 ? 36.89400  -27.59300 8.83100   1.000 22.23000  ? 111 LEU A N    1 
ATOM   1659 C CA   . LEU A 1 111 ? 36.30400  -26.98100 10.01900  1.000 19.50000  ? 111 LEU A CA   1 
ATOM   1660 C C    . LEU A 1 111 ? 37.30200  -26.91900 11.16500  1.000 23.43000  ? 111 LEU A C    1 
ATOM   1661 O O    . LEU A 1 111 ? 37.36100  -25.91400 11.89700  1.000 27.35000  ? 111 LEU A O    1 
ATOM   1662 C CB   . LEU A 1 111 ? 35.07200  -27.79500 10.44700  1.000 23.41000  ? 111 LEU A CB   1 
ATOM   1663 C CG   . LEU A 1 111 ? 33.85600  -27.63400 9.55500   1.000 23.23000  ? 111 LEU A CG   1 
ATOM   1664 C CD1  . LEU A 1 111 ? 32.78400  -28.63000 10.03900  1.000 26.18000  ? 111 LEU A CD1  1 
ATOM   1665 C CD2  . LEU A 1 111 ? 33.30500  -26.24000 9.59200   1.000 22.18000  ? 111 LEU A CD2  1 
ATOM   1666 H H    . LEU A 1 111 ? 36.50000  -28.30400 8.54900   1.000 26.69000  ? 111 LEU A H    1 
ATOM   1667 H HA   . LEU A 1 111 ? 36.03100  -26.07500 9.80600   1.000 23.42000  ? 111 LEU A HA   1 
ATOM   1668 H HB2  . LEU A 1 111 ? 35.31100  -28.73500 10.44800  1.000 28.11000  ? 111 LEU A HB2  1 
ATOM   1669 H HB3  . LEU A 1 111 ? 34.81600  -27.51700 11.34100  1.000 28.11000  ? 111 LEU A HB3  1 
ATOM   1670 H HG   . LEU A 1 111 ? 34.10700  -27.80900 8.63400   1.000 27.90000  ? 111 LEU A HG   1 
ATOM   1671 H HD11 . LEU A 1 111 ? 31.95500  -28.45700 9.56500   1.000 31.43000  ? 111 LEU A HD11 1 
ATOM   1672 H HD12 . LEU A 1 111 ? 33.08600  -29.53300 9.85800   1.000 31.43000  ? 111 LEU A HD12 1 
ATOM   1673 H HD13 . LEU A 1 111 ? 32.64900  -28.51100 10.99300  1.000 31.43000  ? 111 LEU A HD13 1 
ATOM   1674 H HD21 . LEU A 1 111 ? 32.39000  -26.25400 9.27100   1.000 26.63000  ? 111 LEU A HD21 1 
ATOM   1675 H HD22 . LEU A 1 111 ? 33.33000  -25.91500 10.50600  1.000 26.63000  ? 111 LEU A HD22 1 
ATOM   1676 H HD23 . LEU A 1 111 ? 33.84700  -25.67100 9.02400   1.000 26.63000  ? 111 LEU A HD23 1 
ATOM   1677 N N    A SER A 1 112 ? 38.05500  -27.99700 11.36800  0.720 23.88000  ? 112 SER A N    1 
ATOM   1678 N N    B SER A 1 112 ? 38.06200  -27.99600 11.36100  0.280 23.84000  ? 112 SER A N    1 
ATOM   1679 C CA   A SER A 1 112 ? 39.02700  -28.01800 12.45700  0.720 26.11000  ? 112 SER A CA   1 
ATOM   1680 C CA   B SER A 1 112 ? 39.02500  -28.02200 12.45300  0.280 25.72000  ? 112 SER A CA   1 
ATOM   1681 C C    A SER A 1 112 ? 40.04000  -26.90300 12.29000  0.720 28.55000  ? 112 SER A C    1 
ATOM   1682 C C    B SER A 1 112 ? 40.06100  -26.92600 12.28700  0.280 28.45000  ? 112 SER A C    1 
ATOM   1683 O O    A SER A 1 112 ? 40.55300  -26.36800 13.28300  0.720 30.37000  ? 112 SER A O    1 
ATOM   1684 O O    B SER A 1 112 ? 40.61800  -26.43200 13.27500  0.280 29.72000  ? 112 SER A O    1 
ATOM   1685 C CB   A SER A 1 112 ? 39.73500  -29.36700 12.51600  0.720 33.28000  ? 112 SER A CB   1 
ATOM   1686 C CB   B SER A 1 112 ? 39.71000  -29.38200 12.52300  0.280 33.61000  ? 112 SER A CB   1 
ATOM   1687 O OG   A SER A 1 112 ? 38.81700  -30.42800 12.54600  0.720 41.25000  ? 112 SER A OG   1 
ATOM   1688 O OG   B SER A 1 112 ? 40.72600  -29.35500 13.50900  0.280 31.18000  ? 112 SER A OG   1 
ATOM   1689 H H    A SER A 1 112 ? 38.02500  -28.71600 10.89800  0.720 28.68000  ? 112 SER A H    1 
ATOM   1690 H H    B SER A 1 112 ? 38.03800  -28.71100 10.88400  0.280 28.63000  ? 112 SER A H    1 
ATOM   1691 H HA   A SER A 1 112 ? 38.56100  -27.89800 13.29900  0.720 31.35000  ? 112 SER A HA   1 
ATOM   1692 H HA   B SER A 1 112 ? 38.55600  -27.88200 13.29100  0.280 30.89000  ? 112 SER A HA   1 
ATOM   1693 H HB2  A SER A 1 112 ? 40.29700  -29.46100 11.73000  0.720 39.95000  ? 112 SER A HB2  1 
ATOM   1694 H HB2  B SER A 1 112 ? 39.05500  -30.05900 12.75600  0.280 40.35000  ? 112 SER A HB2  1 
ATOM   1695 H HB3  A SER A 1 112 ? 40.27900  -29.40100 13.31800  0.720 39.95000  ? 112 SER A HB3  1 
ATOM   1696 H HB3  B SER A 1 112 ? 40.10500  -29.58600 11.66100  0.280 40.35000  ? 112 SER A HB3  1 
ATOM   1697 H HG   A SER A 1 112 ? 38.47800  -30.53600 11.78500  0.720 49.51000  ? 112 SER A HG   1 
ATOM   1698 H HG   B SER A 1 112 ? 40.45300  -28.94800 14.19200  0.280 37.43000  ? 112 SER A HG   1 
ATOM   1699 N N    . ALA A 1 113 ? 40.32800  -26.53800 11.05100  1.000 26.18000  ? 113 ALA A N    1 
ATOM   1700 C CA   . ALA A 1 113 ? 41.33000  -25.50500 10.74000  1.000 25.64000  ? 113 ALA A CA   1 
ATOM   1701 C C    . ALA A 1 113 ? 40.78100  -24.09000 10.76900  1.000 25.33000  ? 113 ALA A C    1 
ATOM   1702 O O    . ALA A 1 113 ? 41.56000  -23.10900 10.66400  1.000 25.56000  ? 113 ALA A O    1 
ATOM   1703 C CB   . ALA A 1 113 ? 41.92200  -25.79800 9.38000   1.000 24.31000  ? 113 ALA A CB   1 
ATOM   1704 H H    . ALA A 1 113 ? 39.95500  -26.87300 10.35200  1.000 31.43000  ? 113 ALA A H    1 
ATOM   1705 H HA   . ALA A 1 113 ? 42.03800  -25.53800 11.40200  1.000 30.78000  ? 113 ALA A HA   1 
ATOM   1706 H HB1  . ALA A 1 113 ? 42.73300  -25.27700 9.27000   1.000 29.19000  ? 113 ALA A HB1  1 
ATOM   1707 H HB2  . ALA A 1 113 ? 42.12600  -26.74400 9.32200   1.000 29.19000  ? 113 ALA A HB2  1 
ATOM   1708 H HB3  . ALA A 1 113 ? 41.27800  -25.55500 8.69700   1.000 29.19000  ? 113 ALA A HB3  1 
ATOM   1709 N N    . GLY A 1 114 ? 39.47900  -23.92900 10.97400  1.000 25.86000  ? 114 GLY A N    1 
ATOM   1710 C CA   . GLY A 1 114 ? 38.89500  -22.61300 11.06800  1.000 25.77000  ? 114 GLY A CA   1 
ATOM   1711 C C    . GLY A 1 114 ? 37.89100  -22.28400 10.01100  1.000 21.76000  ? 114 GLY A C    1 
ATOM   1712 O O    . GLY A 1 114 ? 37.35500  -21.17700 10.02900  1.000 22.04000  ? 114 GLY A O    1 
ATOM   1713 H H    . GLY A 1 114 ? 38.91700  -24.57400 11.06200  1.000 31.05000  ? 114 GLY A H    1 
ATOM   1714 H HA2  . GLY A 1 114 ? 38.45500  -22.53100 11.92800  1.000 30.94000  ? 114 GLY A HA2  1 
ATOM   1715 H HA3  . GLY A 1 114 ? 39.60600  -21.95500 11.01300  1.000 30.94000  ? 114 GLY A HA3  1 
ATOM   1716 N N    . ALA A 1 115 ? 37.57800  -23.19600 9.10200   1.000 21.81000  ? 115 ALA A N    1 
ATOM   1717 C CA   . ALA A 1 115 ? 36.66800  -22.85000 8.02400   1.000 20.25000  ? 115 ALA A CA   1 
ATOM   1718 C C    . ALA A 1 115 ? 35.30200  -22.42300 8.53100   1.000 19.60000  ? 115 ALA A C    1 
ATOM   1719 O O    . ALA A 1 115 ? 34.79800  -22.94400 9.52400   1.000 24.49000  ? 115 ALA A O    1 
ATOM   1720 C CB   . ALA A 1 115 ? 36.46400  -24.06200 7.11300   1.000 20.97000  ? 115 ALA A CB   1 
ATOM   1721 H H    . ALA A 1 115 ? 37.87200  -24.00300 9.08700   1.000 26.19000  ? 115 ALA A H    1 
ATOM   1722 H HA   . ALA A 1 115 ? 37.05900  -22.10900 7.53500   1.000 24.32000  ? 115 ALA A HA   1 
ATOM   1723 H HB1  . ALA A 1 115 ? 35.84700  -23.82300 6.40400   1.000 25.19000  ? 115 ALA A HB1  1 
ATOM   1724 H HB2  . ALA A 1 115 ? 37.31900  -24.32000 6.73500   1.000 25.19000  ? 115 ALA A HB2  1 
ATOM   1725 H HB3  . ALA A 1 115 ? 36.09900  -24.79200 7.63700   1.000 25.19000  ? 115 ALA A HB3  1 
ATOM   1726 N N    . ASP A 1 116 ? 34.69400  -21.54400 7.76800   1.000 21.50000  ? 116 ASP A N    1 
ATOM   1727 C CA   . ASP A 1 116 ? 33.31900  -21.09400 7.99400   1.000 20.35000  ? 116 ASP A CA   1 
ATOM   1728 C C    . ASP A 1 116 ? 32.38600  -22.23200 7.52400   1.000 27.14000  ? 116 ASP A C    1 
ATOM   1729 O O    . ASP A 1 116 ? 32.57300  -22.79900 6.44600   1.000 23.71000  ? 116 ASP A O    1 
ATOM   1730 C CB   . ASP A 1 116 ? 33.09600  -19.83500 7.20600   1.000 23.03000  ? 116 ASP A CB   1 
ATOM   1731 C CG   . ASP A 1 116 ? 31.78500  -19.14700 7.56300   1.000 42.27000  ? 116 ASP A CG   1 
ATOM   1732 O OD1  . ASP A 1 116 ? 30.75700  -19.79500 7.56200   1.000 32.14000  ? 116 ASP A OD1  1 
ATOM   1733 O OD2  . ASP A 1 116 ? 31.79400  -17.95500 7.92500   1.000 56.73000  ? 116 ASP A OD2  1 
ATOM   1734 H H    . ASP A 1 116 ? 35.06000  -21.17200 7.08400   1.000 25.82000  ? 116 ASP A H    1 
ATOM   1735 H HA   . ASP A 1 116 ? 33.13300  -20.89800 8.92600   1.000 24.44000  ? 116 ASP A HA   1 
ATOM   1736 H HB2  . ASP A 1 116 ? 33.82000  -19.21500 7.38600   1.000 27.65000  ? 116 ASP A HB2  1 
ATOM   1737 H HB3  . ASP A 1 116 ? 33.07300  -20.05300 6.26100   1.000 27.65000  ? 116 ASP A HB3  1 
ATOM   1738 N N    . VAL A 1 117 ? 31.40000  -22.55100 8.34100   1.000 22.96000  ? 117 VAL A N    1 
ATOM   1739 C CA   . VAL A 1 117 ? 30.45100  -23.61400 8.03500   1.000 22.50000  ? 117 VAL A CA   1 
ATOM   1740 C C    . VAL A 1 117 ? 29.79800  -23.35000 6.69000   1.000 22.78000  ? 117 VAL A C    1 
ATOM   1741 O O    . VAL A 1 117 ? 29.38600  -24.29900 5.98900   1.000 21.53000  ? 117 VAL A O    1 
ATOM   1742 C CB   . VAL A 1 117 ? 29.40800  -23.71100 9.15700   1.000 22.30000  ? 117 VAL A CB   1 
ATOM   1743 C CG1  . VAL A 1 117 ? 28.20400  -24.60100 8.70300   1.000 25.58000  ? 117 VAL A CG1  1 
ATOM   1744 C CG2  . VAL A 1 117 ? 29.99600  -24.31100 10.40400  1.000 25.04000  ? 117 VAL A CG2  1 
ATOM   1745 H H    . VAL A 1 117 ? 31.25200  -22.16400 9.09400   1.000 27.58000  ? 117 VAL A H    1 
ATOM   1746 H HA   . VAL A 1 117 ? 30.91800  -24.46300 7.98500   1.000 27.02000  ? 117 VAL A HA   1 
ATOM   1747 H HB   . VAL A 1 117 ? 29.10400  -22.81100 9.35300   1.000 26.78000  ? 117 VAL A HB   1 
ATOM   1748 H HG11 . VAL A 1 117 ? 27.69800  -24.87000 9.48500   1.000 30.71000  ? 117 VAL A HG11 1 
ATOM   1749 H HG12 . VAL A 1 117 ? 27.64000  -24.08700 8.10300   1.000 30.71000  ? 117 VAL A HG12 1 
ATOM   1750 H HG13 . VAL A 1 117 ? 28.54600  -25.38400 8.24400   1.000 30.71000  ? 117 VAL A HG13 1 
ATOM   1751 H HG21 . VAL A 1 117 ? 29.43200  -24.08400 11.16000  1.000 30.07000  ? 117 VAL A HG21 1 
ATOM   1752 H HG22 . VAL A 1 117 ? 30.03900  -25.27500 10.30100  1.000 30.07000  ? 117 VAL A HG22 1 
ATOM   1753 H HG23 . VAL A 1 117 ? 30.88800  -23.95300 10.53700  1.000 30.07000  ? 117 VAL A HG23 1 
ATOM   1754 N N    A SER A 1 118 ? 29.70200  -22.08200 6.29100   0.620 20.43000  ? 118 SER A N    1 
ATOM   1755 N N    B SER A 1 118 ? 29.68100  -22.07700 6.30100   0.380 20.48000  ? 118 SER A N    1 
ATOM   1756 C CA   A SER A 1 118 ? 29.07300  -21.70900 5.03700   0.620 22.49000  ? 118 SER A CA   1 
ATOM   1757 C CA   B SER A 1 118 ? 29.05000  -21.71800 5.03900   0.380 22.52000  ? 118 SER A CA   1 
ATOM   1758 C C    A SER A 1 118 ? 29.78900  -22.28400 3.83500   0.620 24.70000  ? 118 SER A C    1 
ATOM   1759 C C    B SER A 1 118 ? 29.79100  -22.27500 3.83300   0.380 24.25000  ? 118 SER A C    1 
ATOM   1760 O O    A SER A 1 118 ? 29.22900  -22.22300 2.72700   0.620 27.36000  ? 118 SER A O    1 
ATOM   1761 O O    B SER A 1 118 ? 29.24800  -22.20000 2.72000   0.380 27.49000  ? 118 SER A O    1 
ATOM   1762 C CB   A SER A 1 118 ? 28.96800  -20.19300 4.90700   0.620 29.84000  ? 118 SER A CB   1 
ATOM   1763 C CB   B SER A 1 118 ? 28.90500  -20.19600 4.90400   0.380 29.61000  ? 118 SER A CB   1 
ATOM   1764 O OG   A SER A 1 118 ? 28.95200  -19.83300 3.53700   0.620 40.66000  ? 118 SER A OG   1 
ATOM   1765 O OG   B SER A 1 118 ? 30.12900  -19.49700 5.04700   0.380 25.31000  ? 118 SER A OG   1 
ATOM   1766 H H    A SER A 1 118 ? 30.00000  -21.41100 6.74000   0.620 24.54000  ? 118 SER A H    1 
ATOM   1767 H H    B SER A 1 118 ? 29.96200  -21.40300 6.75500   0.380 24.60000  ? 118 SER A H    1 
ATOM   1768 H HA   A SER A 1 118 ? 28.16700  -22.05500 5.04200   0.620 27.01000  ? 118 SER A HA   1 
ATOM   1769 H HA   B SER A 1 118 ? 28.15400  -22.08900 5.04100   0.380 27.04000  ? 118 SER A HA   1 
ATOM   1770 H HB2  A SER A 1 118 ? 28.14800  -19.89100 5.32700   0.620 35.83000  ? 118 SER A HB2  1 
ATOM   1771 H HB2  B SER A 1 118 ? 28.54300  -20.00000 4.02600   0.380 35.55000  ? 118 SER A HB2  1 
ATOM   1772 H HB3  A SER A 1 118 ? 29.73400  -19.78100 5.33700   0.620 35.83000  ? 118 SER A HB3  1 
ATOM   1773 H HB3  B SER A 1 118 ? 28.29500  -19.88500 5.59100   0.380 35.55000  ? 118 SER A HB3  1 
ATOM   1774 H HG   A SER A 1 118 ? 28.84300  -19.00400 3.45900   0.620 48.81000  ? 118 SER A HG   1 
ATOM   1775 H HG   B SER A 1 118 ? 30.00400  -18.78400 5.47400   0.380 30.40000  ? 118 SER A HG   1 
ATOM   1776 N N    . MET A 1 119 ? 31.00400  -22.82900 4.00400   1.000 24.81000  ? 119 MET A N    1 
ATOM   1777 C CA   . MET A 1 119 ? 31.72200  -23.41500 2.88200   1.000 27.87000  ? 119 MET A CA   1 
ATOM   1778 C C    . MET A 1 119 ? 31.31300  -24.85300 2.61700   1.000 27.48000  ? 119 MET A C    1 
ATOM   1779 O O    . MET A 1 119 ? 31.89100  -25.51800 1.74600   1.000 25.08000  ? 119 MET A O    1 
ATOM   1780 C CB   . MET A 1 119 ? 33.24500  -23.28200 3.09200   1.000 35.56000  ? 119 MET A CB   1 
ATOM   1781 C CG   . MET A 1 119 ? 33.65000  -21.78600 3.28900   1.000 47.28000  ? 119 MET A CG   1 
ATOM   1782 S SD   . MET A 1 119 ? 33.63000  -20.64200 1.83000   1.000 67.22000  ? 119 MET A SD   1 
ATOM   1783 C CE   . MET A 1 119 ? 31.96400  -19.97900 1.85900   1.000 53.52000  ? 119 MET A CE   1 
ATOM   1784 H H    . MET A 1 119 ? 31.42300  -22.86700 4.75400   1.000 29.79000  ? 119 MET A H    1 
ATOM   1785 H HA   . MET A 1 119 ? 31.52000  -22.90700 2.08100   1.000 33.46000  ? 119 MET A HA   1 
ATOM   1786 H HB2  . MET A 1 119 ? 33.50700  -23.78000 3.88200   1.000 42.69000  ? 119 MET A HB2  1 
ATOM   1787 H HB3  . MET A 1 119 ? 33.70900  -23.62700 2.31300   1.000 42.69000  ? 119 MET A HB3  1 
ATOM   1788 H HG2  . MET A 1 119 ? 33.04300  -21.40400 3.94200   1.000 56.75000  ? 119 MET A HG2  1 
ATOM   1789 H HG3  . MET A 1 119 ? 34.55700  -21.77300 3.63300   1.000 56.75000  ? 119 MET A HG3  1 
ATOM   1790 H HE1  . MET A 1 119 ? 31.85400  -19.36800 1.11300   1.000 64.24000  ? 119 MET A HE1  1 
ATOM   1791 H HE2  . MET A 1 119 ? 31.33100  -20.71100 1.78300   1.000 64.24000  ? 119 MET A HE2  1 
ATOM   1792 H HE3  . MET A 1 119 ? 31.82500  -19.50800 2.69500   1.000 64.24000  ? 119 MET A HE3  1 
ATOM   1793 N N    . ILE A 1 120 ? 30.30100  -25.34600 3.32600   1.000 21.25000  ? 120 ILE A N    1 
ATOM   1794 C CA   . ILE A 1 120 ? 29.96100  -26.75200 3.25600   1.000 17.99000  ? 120 ILE A CA   1 
ATOM   1795 C C    . ILE A 1 120 ? 29.62800  -27.17000 1.82100   1.000 22.45000  ? 120 ILE A C    1 
ATOM   1796 O O    . ILE A 1 120 ? 29.91800  -28.29500 1.43400   1.000 24.09000  ? 120 ILE A O    1 
ATOM   1797 C CB   . ILE A 1 120 ? 28.78500  -27.05900 4.22700   1.000 20.83000  ? 120 ILE A CB   1 
ATOM   1798 C CG1  . ILE A 1 120 ? 28.52100  -28.55600 4.31100   1.000 22.13000  ? 120 ILE A CG1  1 
ATOM   1799 C CG2  . ILE A 1 120 ? 27.54700  -26.25800 3.87800   1.000 20.47000  ? 120 ILE A CG2  1 
ATOM   1800 C CD1  . ILE A 1 120 ? 27.60000  -28.99500 5.47200   1.000 21.27000  ? 120 ILE A CD1  1 
ATOM   1801 H H    . ILE A 1 120 ? 29.80100  -24.88500 3.85200   1.000 25.52000  ? 120 ILE A H    1 
ATOM   1802 H HA   . ILE A 1 120 ? 30.73400  -27.26600 3.53400   1.000 21.61000  ? 120 ILE A HA   1 
ATOM   1803 H HB   . ILE A 1 120 ? 29.04900  -26.77400 5.11600   1.000 25.01000  ? 120 ILE A HB   1 
ATOM   1804 H HG12 . ILE A 1 120 ? 28.10100  -28.84100 3.48400   1.000 26.57000  ? 120 ILE A HG12 1 
ATOM   1805 H HG13 . ILE A 1 120 ? 29.37000  -29.01200 4.42500   1.000 26.57000  ? 120 ILE A HG13 1 
ATOM   1806 H HG21 . ILE A 1 120 ? 26.90100  -26.34500 4.59600   1.000 24.58000  ? 120 ILE A HG21 1 
ATOM   1807 H HG22 . ILE A 1 120 ? 27.79500  -25.32600 3.76800   1.000 24.58000  ? 120 ILE A HG22 1 
ATOM   1808 H HG23 . ILE A 1 120 ? 27.17200  -26.60000 3.05200   1.000 24.58000  ? 120 ILE A HG23 1 
ATOM   1809 H HD11 . ILE A 1 120 ? 27.61100  -29.96300 5.53500   1.000 25.54000  ? 120 ILE A HD11 1 
ATOM   1810 H HD12 . ILE A 1 120 ? 27.92700  -28.60600 6.29900   1.000 25.54000  ? 120 ILE A HD12 1 
ATOM   1811 H HD13 . ILE A 1 120 ? 26.69800  -28.68600 5.29400   1.000 25.54000  ? 120 ILE A HD13 1 
ATOM   1812 N N    . GLY A 1 121 ? 29.00000  -26.29400 1.05400   1.000 24.00000  ? 121 GLY A N    1 
ATOM   1813 C CA   . GLY A 1 121 ? 28.61700  -26.65000 -0.31400  1.000 25.99000  ? 121 GLY A CA   1 
ATOM   1814 C C    . GLY A 1 121 ? 29.78100  -26.87200 -1.23800  1.000 37.50000  ? 121 GLY A C    1 
ATOM   1815 O O    . GLY A 1 121 ? 29.68300  -27.63000 -2.19900  1.000 33.34000  ? 121 GLY A O    1 
ATOM   1816 H H    . GLY A 1 121 ? 28.78400  -25.49600 1.29100   1.000 28.82000  ? 121 GLY A H    1 
ATOM   1817 H HA2  . GLY A 1 121 ? 28.09400  -27.46700 -0.29100  1.000 31.21000  ? 121 GLY A HA2  1 
ATOM   1818 H HA3  . GLY A 1 121 ? 28.07400  -25.93700 -0.68400  1.000 31.21000  ? 121 GLY A HA3  1 
ATOM   1819 N N    . GLN A 1 122 ? 30.90000  -26.24400 -0.94800  1.000 27.25000  ? 122 GLN A N    1 
ATOM   1820 C CA   . GLN A 1 122 ? 32.09600  -26.38500 -1.75200  1.000 27.70000  ? 122 GLN A CA   1 
ATOM   1821 C C    . GLN A 1 122 ? 32.69600  -27.75500 -1.62900  1.000 24.99000  ? 122 GLN A C    1 
ATOM   1822 O O    . GLN A 1 122 ? 33.57400  -28.09700 -2.44500  1.000 35.91000  ? 122 GLN A O    1 
ATOM   1823 C CB   . GLN A 1 122 ? 33.12500  -25.33500 -1.33800  1.000 27.24000  ? 122 GLN A CB   1 
ATOM   1824 C CG   . GLN A 1 122 ? 32.69300  -23.94600 -1.62800  1.000 39.52000  ? 122 GLN A CG   1 
ATOM   1825 C CD   . GLN A 1 122 ? 33.83300  -22.98000 -1.47900  1.000 62.38000  ? 122 GLN A CD   1 
ATOM   1826 O OE1  . GLN A 1 122 ? 34.38900  -22.81000 -0.38400  1.000 61.14000  ? 122 GLN A OE1  1 
ATOM   1827 N NE2  . GLN A 1 122 ? 34.20100  -22.34300 -2.58300  1.000 67.41000  ? 122 GLN A NE2  1 
ATOM   1828 H H    . GLN A 1 122 ? 30.99700  -25.71600 -0.27500  1.000 32.72000  ? 122 GLN A H    1 
ATOM   1829 H HA   . GLN A 1 122 ? 31.87400  -26.23200 -2.68400  1.000 33.26000  ? 122 GLN A HA   1 
ATOM   1830 H HB2  . GLN A 1 122 ? 33.27900  -25.40600 -0.38300  1.000 32.71000  ? 122 GLN A HB2  1 
ATOM   1831 H HB3  . GLN A 1 122 ? 33.95000  -25.49700 -1.82000  1.000 32.71000  ? 122 GLN A HB3  1 
ATOM   1832 H HG2  . GLN A 1 122 ? 32.36500  -23.89400 -2.54000  1.000 47.44000  ? 122 GLN A HG2  1 
ATOM   1833 H HG3  . GLN A 1 122 ? 31.99200  -23.69000 -1.00900  1.000 47.44000  ? 122 GLN A HG3  1 
ATOM   1834 H HE21 . GLN A 1 122 ? 33.79300  -22.49500 -3.32400  1.000 80.91000  ? 122 GLN A HE21 1 
ATOM   1835 H HE22 . GLN A 1 122 ? 34.84900  -21.77700 -2.55700  1.000 80.91000  ? 122 GLN A HE22 1 
ATOM   1836 N N    . PHE A 1 123 ? 32.24600  -28.54400 -0.67800  1.000 25.79000  ? 123 PHE A N    1 
ATOM   1837 C CA   . PHE A 1 123 ? 32.65500  -29.91100 -0.45100  1.000 24.72000  ? 123 PHE A CA   1 
ATOM   1838 C C    . PHE A 1 123 ? 31.59100  -30.91500 -0.87300  1.000 31.69000  ? 123 PHE A C    1 
ATOM   1839 O O    . PHE A 1 123 ? 31.71100  -32.11700 -0.55400  1.000 31.34000  ? 123 PHE A O    1 
ATOM   1840 C CB   . PHE A 1 123 ? 33.01800  -30.14600 1.03600   1.000 33.30000  ? 123 PHE A CB   1 
ATOM   1841 C CG   . PHE A 1 123 ? 34.23000  -29.36700 1.49800   1.000 29.50000  ? 123 PHE A CG   1 
ATOM   1842 C CD1  . PHE A 1 123 ? 34.12100  -28.02100 1.80500   1.000 36.94000  ? 123 PHE A CD1  1 
ATOM   1843 C CD2  . PHE A 1 123 ? 35.48500  -29.95200 1.53400   1.000 39.72000  ? 123 PHE A CD2  1 
ATOM   1844 C CE1  . PHE A 1 123 ? 35.22300  -27.28200 2.20300   1.000 36.79000  ? 123 PHE A CE1  1 
ATOM   1845 C CE2  . PHE A 1 123 ? 36.60700  -29.19900 1.91500   1.000 33.48000  ? 123 PHE A CE2  1 
ATOM   1846 C CZ   . PHE A 1 123 ? 36.47800  -27.88500 2.23600   1.000 31.93000  ? 123 PHE A CZ   1 
ATOM   1847 H H    . PHE A 1 123 ? 31.65500  -28.29200 -0.10600  1.000 30.96000  ? 123 PHE A H    1 
ATOM   1848 H HA   . PHE A 1 123 ? 33.45700  -30.07200 -0.97200  1.000 29.68000  ? 123 PHE A HA   1 
ATOM   1849 H HB2  . PHE A 1 123 ? 32.26600  -29.87800 1.58600   1.000 39.98000  ? 123 PHE A HB2  1 
ATOM   1850 H HB3  . PHE A 1 123 ? 33.20400  -31.08900 1.16500   1.000 39.98000  ? 123 PHE A HB3  1 
ATOM   1851 H HD1  . PHE A 1 123 ? 33.29200  -27.60500 1.74300   1.000 44.35000  ? 123 PHE A HD1  1 
ATOM   1852 H HD2  . PHE A 1 123 ? 35.58500  -30.84800 1.30400   1.000 47.69000  ? 123 PHE A HD2  1 
ATOM   1853 H HE1  . PHE A 1 123 ? 35.12500  -26.38900 2.44600   1.000 44.17000  ? 123 PHE A HE1  1 
ATOM   1854 H HE2  . PHE A 1 123 ? 37.44500  -29.60200 1.94800   1.000 40.19000  ? 123 PHE A HE2  1 
ATOM   1855 H HZ   . PHE A 1 123 ? 37.22700  -27.38900 2.47600   1.000 38.34000  ? 123 PHE A HZ   1 
ATOM   1856 N N    . GLY A 1 124 ? 30.49500  -30.44100 -1.43300  1.000 30.84000  ? 124 GLY A N    1 
ATOM   1857 C CA   . GLY A 1 124 ? 29.46700  -31.32100 -1.97900  1.000 37.11000  ? 124 GLY A CA   1 
ATOM   1858 C C    . GLY A 1 124 ? 28.51600  -31.95200 -0.98400  1.000 40.00000  ? 124 GLY A C    1 
ATOM   1859 O O    . GLY A 1 124 ? 27.78200  -32.87100 -1.37100  1.000 30.62000  ? 124 GLY A O    1 
ATOM   1860 H H    . GLY A 1 124 ? 30.31500  -29.60300 -1.51200  1.000 37.03000  ? 124 GLY A H    1 
ATOM   1861 H HA2  . GLY A 1 124 ? 28.93200  -30.81000 -2.60600  1.000 44.55000  ? 124 GLY A HA2  1 
ATOM   1862 H HA3  . GLY A 1 124 ? 29.90700  -32.04300 -2.45500  1.000 44.55000  ? 124 GLY A HA3  1 
ATOM   1863 N N    . VAL A 1 125 ? 28.48300  -31.46900 0.27200   1.000 25.47000  ? 125 VAL A N    1 
ATOM   1864 C CA   . VAL A 1 125 ? 27.70100  -32.07400 1.33900   1.000 22.62000  ? 125 VAL A CA   1 
ATOM   1865 C C    . VAL A 1 125 ? 26.76300  -31.03400 1.99500   1.000 17.22000  ? 125 VAL A C    1 
ATOM   1866 O O    . VAL A 1 125 ? 26.35600  -31.23100 3.13500   1.000 20.89000  ? 125 VAL A O    1 
ATOM   1867 C CB   . VAL A 1 125 ? 28.56600  -32.74500 2.40800   1.000 29.65000  ? 125 VAL A CB   1 
ATOM   1868 C CG1  . VAL A 1 125 ? 29.18500  -34.06700 1.86600   1.000 39.10000  ? 125 VAL A CG1  1 
ATOM   1869 C CG2  . VAL A 1 125 ? 29.72500  -31.82300 2.89000   1.000 25.26000  ? 125 VAL A CG2  1 
ATOM   1870 H H    . VAL A 1 125 ? 28.92000  -30.77400 0.52700   1.000 30.58000  ? 125 VAL A H    1 
ATOM   1871 H HA   . VAL A 1 125 ? 27.15600  -32.75600 0.91700   1.000 27.16000  ? 125 VAL A HA   1 
ATOM   1872 H HB   . VAL A 1 125 ? 27.98500  -32.93200 3.16200   1.000 35.60000  ? 125 VAL A HB   1 
ATOM   1873 H HG11 . VAL A 1 125 ? 29.73500  -34.46600 2.55800   1.000 46.94000  ? 125 VAL A HG11 1 
ATOM   1874 H HG12 . VAL A 1 125 ? 28.46900  -34.67400 1.62100   1.000 46.94000  ? 125 VAL A HG12 1 
ATOM   1875 H HG13 . VAL A 1 125 ? 29.72800  -33.86600 1.08800   1.000 46.94000  ? 125 VAL A HG13 1 
ATOM   1876 H HG21 . VAL A 1 125 ? 29.91500  -32.01500 3.82200   1.000 30.33000  ? 125 VAL A HG21 1 
ATOM   1877 H HG22 . VAL A 1 125 ? 30.51200  -31.99500 2.35000   1.000 30.33000  ? 125 VAL A HG22 1 
ATOM   1878 H HG23 . VAL A 1 125 ? 29.45300  -30.89700 2.79200   1.000 30.33000  ? 125 VAL A HG23 1 
ATOM   1879 N N    . GLY A 1 126 ? 26.33300  -30.03000 1.22100   1.000 20.48000  ? 126 GLY A N    1 
ATOM   1880 C CA   . GLY A 1 126 ? 25.46900  -28.97200 1.71500   1.000 21.47000  ? 126 GLY A CA   1 
ATOM   1881 C C    . GLY A 1 126 ? 24.12500  -29.43000 2.23600   1.000 19.38000  ? 126 GLY A C    1 
ATOM   1882 O O    . GLY A 1 126 ? 23.54900  -28.76100 3.10000   1.000 19.01000  ? 126 GLY A O    1 
ATOM   1883 H H    . GLY A 1 126 ? 26.53600  -29.94300 0.38900   1.000 24.59000  ? 126 GLY A H    1 
ATOM   1884 H HA2  . GLY A 1 126 ? 25.92400  -28.51300 2.43800   1.000 25.79000  ? 126 GLY A HA2  1 
ATOM   1885 H HA3  . GLY A 1 126 ? 25.30700  -28.34300 0.99500   1.000 25.79000  ? 126 GLY A HA3  1 
ATOM   1886 N N    . PHE A 1 127 ? 23.60600  -30.58100 1.77200   1.000 19.00000  ? 127 PHE A N    1 
ATOM   1887 C CA   . PHE A 1 127 ? 22.36300  -31.11000 2.32500   1.000 17.39000  ? 127 PHE A CA   1 
ATOM   1888 C C    . PHE A 1 127 ? 22.39700  -31.17300 3.84900   1.000 19.84000  ? 127 PHE A C    1 
ATOM   1889 O O    . PHE A 1 127 ? 21.43100  -30.83500 4.53100   1.000 17.20000  ? 127 PHE A O    1 
ATOM   1890 C CB   . PHE A 1 127 ? 22.15700  -32.53300 1.76300   1.000 18.54000  ? 127 PHE A CB   1 
ATOM   1891 C CG   . PHE A 1 127 ? 21.11700  -33.37700 2.48200   1.000 18.24000  ? 127 PHE A CG   1 
ATOM   1892 C CD1  . PHE A 1 127 ? 19.76200  -33.06500 2.41000   1.000 16.30000  ? 127 PHE A CD1  1 
ATOM   1893 C CD2  . PHE A 1 127 ? 21.47300  -34.53900 3.17600   1.000 21.16000  ? 127 PHE A CD2  1 
ATOM   1894 C CE1  . PHE A 1 127 ? 18.80800  -33.83700 2.98900   1.000 17.63000  ? 127 PHE A CE1  1 
ATOM   1895 C CE2  . PHE A 1 127 ? 20.46200  -35.33000 3.79900   1.000 21.98000  ? 127 PHE A CE2  1 
ATOM   1896 C CZ   . PHE A 1 127 ? 19.08100  -34.94800 3.67100   1.000 19.18000  ? 127 PHE A CZ   1 
ATOM   1897 H H    . PHE A 1 127 ? 23.95300  -31.06100 1.14800   1.000 22.82000  ? 127 PHE A H    1 
ATOM   1898 H HA   . PHE A 1 127 ? 21.62800  -30.53200 2.06800   1.000 20.88000  ? 127 PHE A HA   1 
ATOM   1899 H HB2  . PHE A 1 127 ? 21.87700  -32.45800 0.83700   1.000 22.27000  ? 127 PHE A HB2  1 
ATOM   1900 H HB3  . PHE A 1 127 ? 23.00100  -33.00800 1.81700   1.000 22.27000  ? 127 PHE A HB3  1 
ATOM   1901 H HD1  . PHE A 1 127 ? 19.50100  -32.30100 1.94800   1.000 19.57000  ? 127 PHE A HD1  1 
ATOM   1902 H HD2  . PHE A 1 127 ? 22.36600  -34.79500 3.23200   1.000 25.41000  ? 127 PHE A HD2  1 
ATOM   1903 H HE1  . PHE A 1 127 ? 17.91900  -33.57800 2.90600   1.000 21.17000  ? 127 PHE A HE1  1 
ATOM   1904 H HE2  . PHE A 1 127 ? 20.69400  -36.08800 4.28500   1.000 26.40000  ? 127 PHE A HE2  1 
ATOM   1905 H HZ   . PHE A 1 127 ? 18.40400  -35.45800 4.05200   1.000 23.04000  ? 127 PHE A HZ   1 
ATOM   1906 N N    . TYR A 1 128 ? 23.53600  -31.56200 4.40900   1.000 17.02000  ? 128 TYR A N    1 
ATOM   1907 C CA   . TYR A 1 128 ? 23.61000  -31.80200 5.87600   1.000 18.83000  ? 128 TYR A CA   1 
ATOM   1908 C C    . TYR A 1 128 ? 23.55500  -30.48700 6.64800   1.000 16.71000  ? 128 TYR A C    1 
ATOM   1909 O O    . TYR A 1 128 ? 23.37900  -30.56700 7.85300   1.000 18.11000  ? 128 TYR A O    1 
ATOM   1910 C CB   . TYR A 1 128 ? 24.85100  -32.65900 6.13900   1.000 20.04000  ? 128 TYR A CB   1 
ATOM   1911 C CG   . TYR A 1 128 ? 24.70000  -34.05900 5.56200   1.000 21.74000  ? 128 TYR A CG   1 
ATOM   1912 C CD1  . TYR A 1 128 ? 23.92700  -35.00900 6.21000   1.000 23.40000  ? 128 TYR A CD1  1 
ATOM   1913 C CD2  . TYR A 1 128 ? 25.28700  -34.41100 4.35500   1.000 24.70000  ? 128 TYR A CD2  1 
ATOM   1914 C CE1  . TYR A 1 128 ? 23.76200  -36.27900 5.68900   1.000 21.51000  ? 128 TYR A CE1  1 
ATOM   1915 C CE2  . TYR A 1 128 ? 25.12700  -35.67800 3.82100   1.000 25.49000  ? 128 TYR A CE2  1 
ATOM   1916 C CZ   . TYR A 1 128 ? 24.36300  -36.61200 4.49300   1.000 25.85000  ? 128 TYR A CZ   1 
ATOM   1917 O OH   . TYR A 1 128 ? 24.18400  -37.86900 4.00400   1.000 35.67000  ? 128 TYR A OH   1 
ATOM   1918 H H    . TYR A 1 128 ? 24.29800  -31.68500 3.94100   1.000 20.45000  ? 128 TYR A H    1 
ATOM   1919 H HA   . TYR A 1 128 ? 22.81500  -32.33800 6.13600   1.000 22.61000  ? 128 TYR A HA   1 
ATOM   1920 H HB2  . TYR A 1 128 ? 25.63100  -32.22300 5.73000   1.000 24.07000  ? 128 TYR A HB2  1 
ATOM   1921 H HB3  . TYR A 1 128 ? 24.99500  -32.72300 7.10800   1.000 24.07000  ? 128 TYR A HB3  1 
ATOM   1922 H HD1  . TYR A 1 128 ? 23.51200  -34.78800 7.02900   1.000 28.10000  ? 128 TYR A HD1  1 
ATOM   1923 H HD2  . TYR A 1 128 ? 25.80800  -33.77600 3.89000   1.000 29.65000  ? 128 TYR A HD2  1 
ATOM   1924 H HE1  . TYR A 1 128 ? 23.24200  -36.91500 6.14900   1.000 25.83000  ? 128 TYR A HE1  1 
ATOM   1925 H HE2  . TYR A 1 128 ? 25.53900  -35.90500 3.00500   1.000 30.61000  ? 128 TYR A HE2  1 
ATOM   1926 H HH   . TYR A 1 128 ? 23.95600  -37.83200 3.17800   1.000 42.83000  ? 128 TYR A HH   1 
ATOM   1927 N N    . SER A 1 129 ? 23.70700  -29.33900 5.99000   1.000 16.31000  ? 129 SER A N    1 
ATOM   1928 C CA   . SER A 1 129 ? 23.50900  -28.07200 6.68400   1.000 15.97000  ? 129 SER A CA   1 
ATOM   1929 C C    . SER A 1 129 ? 22.10200  -27.92300 7.23500   1.000 15.47000  ? 129 SER A C    1 
ATOM   1930 O O    . SER A 1 129 ? 21.85800  -27.03300 8.03800   1.000 17.43000  ? 129 SER A O    1 
ATOM   1931 C CB   . SER A 1 129 ? 23.82800  -26.88700 5.82400   1.000 17.59000  ? 129 SER A CB   1 
ATOM   1932 O OG   . SER A 1 129 ? 22.87600  -26.69000 4.74600   1.000 18.92000  ? 129 SER A OG   1 
ATOM   1933 H H    . SER A 1 129 ? 23.90100  -29.27000 5.15500   1.000 19.59000  ? 129 SER A H    1 
ATOM   1934 H HA   . SER A 1 129 ? 24.14400  -28.05600 7.41700   1.000 19.18000  ? 129 SER A HA   1 
ATOM   1935 H HB2  . SER A 1 129 ? 23.82600  -26.09400 6.38200   1.000 21.12000  ? 129 SER A HB2  1 
ATOM   1936 H HB3  . SER A 1 129 ? 24.70700  -27.01800 5.43600   1.000 21.12000  ? 129 SER A HB3  1 
ATOM   1937 H HG   . SER A 1 129 ? 22.70300  -27.42500 4.37800   1.000 22.72000  ? 129 SER A HG   1 
ATOM   1938 N N    . LEU A 1 130 ? 21.12400  -28.74600 6.82100   1.000 16.41000  ? 130 LEU A N    1 
ATOM   1939 C CA   . LEU A 1 130 ? 19.78900  -28.58000 7.38100   1.000 14.95000  ? 130 LEU A CA   1 
ATOM   1940 C C    . LEU A 1 130 ? 19.74300  -28.81500 8.87500   1.000 16.52000  ? 130 LEU A C    1 
ATOM   1941 O O    . LEU A 1 130 ? 18.85600  -28.27700 9.53900   1.000 16.16000  ? 130 LEU A O    1 
ATOM   1942 C CB   . LEU A 1 130 ? 18.80200  -29.53000 6.64500   1.000 16.45000  ? 130 LEU A CB   1 
ATOM   1943 C CG   . LEU A 1 130 ? 18.95500  -30.97400 6.95600   1.000 17.62000  ? 130 LEU A CG   1 
ATOM   1944 C CD1  . LEU A 1 130 ? 18.16800  -31.37300 8.19800   1.000 16.83000  ? 130 LEU A CD1  1 
ATOM   1945 C CD2  . LEU A 1 130 ? 18.57000  -31.87300 5.73100   1.000 20.34000  ? 130 LEU A CD2  1 
ATOM   1946 H H    . LEU A 1 130 ? 21.21200  -29.37800 6.24400   1.000 19.72000  ? 130 LEU A H    1 
ATOM   1947 H HA   . LEU A 1 130 ? 19.49600  -27.66700 7.23600   1.000 17.96000  ? 130 LEU A HA   1 
ATOM   1948 H HB2  . LEU A 1 130 ? 17.89700  -29.27600 6.88500   1.000 19.76000  ? 130 LEU A HB2  1 
ATOM   1949 H HB3  . LEU A 1 130 ? 18.93300  -29.42400 5.68900   1.000 19.76000  ? 130 LEU A HB3  1 
ATOM   1950 H HG   . LEU A 1 130 ? 19.89200  -31.13300 7.14900   1.000 21.16000  ? 130 LEU A HG   1 
ATOM   1951 H HD11 . LEU A 1 130 ? 17.87000  -32.29100 8.10200   1.000 20.21000  ? 130 LEU A HD11 1 
ATOM   1952 H HD12 . LEU A 1 130 ? 18.74200  -31.29200 8.97600   1.000 20.21000  ? 130 LEU A HD12 1 
ATOM   1953 H HD13 . LEU A 1 130 ? 17.40200  -30.78500 8.29000   1.000 20.21000  ? 130 LEU A HD13 1 
ATOM   1954 H HD21 . LEU A 1 130 ? 18.80800  -32.79300 5.92800   1.000 24.43000  ? 130 LEU A HD21 1 
ATOM   1955 H HD22 . LEU A 1 130 ? 17.61500  -31.80400 5.57600   1.000 24.43000  ? 130 LEU A HD22 1 
ATOM   1956 H HD23 . LEU A 1 130 ? 19.05500  -31.56600 4.94900   1.000 24.43000  ? 130 LEU A HD23 1 
ATOM   1957 N N    . PHE A 1 131 ? 20.72200  -29.54400 9.41900   1.000 16.89000  ? 131 PHE A N    1 
ATOM   1958 C CA   . PHE A 1 131 ? 20.73500  -29.82500 10.84700  1.000 18.76000  ? 131 PHE A CA   1 
ATOM   1959 C C    . PHE A 1 131 ? 21.13300  -28.59600 11.63500  1.000 19.19000  ? 131 PHE A C    1 
ATOM   1960 O O    . PHE A 1 131 ? 21.01500  -28.60800 12.87800  1.000 21.30000  ? 131 PHE A O    1 
ATOM   1961 C CB   . PHE A 1 131 ? 21.63200  -31.02700 11.08000  1.000 18.44000  ? 131 PHE A CB   1 
ATOM   1962 C CG   . PHE A 1 131 ? 20.99000  -32.32200 10.63600  1.000 20.26000  ? 131 PHE A CG   1 
ATOM   1963 C CD1  . PHE A 1 131 ? 19.95300  -32.84400 11.33500  1.000 21.79000  ? 131 PHE A CD1  1 
ATOM   1964 C CD2  . PHE A 1 131 ? 21.45000  -32.99100 9.49800   1.000 22.28000  ? 131 PHE A CD2  1 
ATOM   1965 C CE1  . PHE A 1 131 ? 19.33900  -34.02400 10.91700  1.000 25.57000  ? 131 PHE A CE1  1 
ATOM   1966 C CE2  . PHE A 1 131 ? 20.86100  -34.12700 9.06700   1.000 23.96000  ? 131 PHE A CE2  1 
ATOM   1967 C CZ   . PHE A 1 131 ? 19.80400  -34.66000 9.79200   1.000 24.83000  ? 131 PHE A CZ   1 
ATOM   1968 H H    . PHE A 1 131 ? 21.38100  -29.88200 8.98200   1.000 20.29000  ? 131 PHE A H    1 
ATOM   1969 H HA   . PHE A 1 131 ? 19.86500  -30.08100 11.19100  1.000 22.53000  ? 131 PHE A HA   1 
ATOM   1970 H HB2  . PHE A 1 131 ? 22.45400  -30.91000 10.57900  1.000 22.15000  ? 131 PHE A HB2  1 
ATOM   1971 H HB3  . PHE A 1 131 ? 21.82700  -31.09600 12.02800  1.000 22.15000  ? 131 PHE A HB3  1 
ATOM   1972 H HD1  . PHE A 1 131 ? 19.64900  -32.41200 12.10100  1.000 26.17000  ? 131 PHE A HD1  1 
ATOM   1973 H HD2  . PHE A 1 131 ? 22.17500  -32.64700 9.02900   1.000 26.76000  ? 131 PHE A HD2  1 
ATOM   1974 H HE1  . PHE A 1 131 ? 18.62300  -34.37600 11.39400  1.000 30.71000  ? 131 PHE A HE1  1 
ATOM   1975 H HE2  . PHE A 1 131 ? 21.16000  -34.54800 8.29300   1.000 28.77000  ? 131 PHE A HE2  1 
ATOM   1976 H HZ   . PHE A 1 131 ? 19.40800  -35.45400 9.51400   1.000 29.81000  ? 131 PHE A HZ   1 
ATOM   1977 N N    . LEU A 1 132 ? 21.49900  -27.50700 10.95200  1.000 18.13000  ? 132 LEU A N    1 
ATOM   1978 C CA   . LEU A 1 132 ? 21.61900  -26.25100 11.67400  1.000 20.06000  ? 132 LEU A CA   1 
ATOM   1979 C C    . LEU A 1 132 ? 20.27500  -25.80100 12.24200  1.000 21.18000  ? 132 LEU A C    1 
ATOM   1980 O O    . LEU A 1 132 ? 20.21700  -25.17400 13.32600  1.000 21.35000  ? 132 LEU A O    1 
ATOM   1981 C CB   . LEU A 1 132 ? 22.14900  -25.20500 10.74500  1.000 19.51000  ? 132 LEU A CB   1 
ATOM   1982 C CG   . LEU A 1 132 ? 23.57300  -25.31900 10.25700  1.000 18.64000  ? 132 LEU A CG   1 
ATOM   1983 C CD1  . LEU A 1 132 ? 23.91200  -24.36100 9.17400   1.000 17.14000  ? 132 LEU A CD1  1 
ATOM   1984 C CD2  . LEU A 1 132 ? 24.57500  -25.16600 11.41500  1.000 20.00000  ? 132 LEU A CD2  1 
ATOM   1985 H H    . LEU A 1 132 ? 21.67500  -27.47500 10.11100  1.000 21.77000  ? 132 LEU A H    1 
ATOM   1986 H HA   . LEU A 1 132 ? 22.23600  -26.36300 12.41400  1.000 24.09000  ? 132 LEU A HA   1 
ATOM   1987 H HB2  . LEU A 1 132 ? 21.58700  -25.20500 9.95500   1.000 23.43000  ? 132 LEU A HB2  1 
ATOM   1988 H HB3  . LEU A 1 132 ? 22.08200  -24.35000 11.20000  1.000 23.43000  ? 132 LEU A HB3  1 
ATOM   1989 H HG   . LEU A 1 132 ? 23.65300  -26.20900 9.87800   1.000 22.39000  ? 132 LEU A HG   1 
ATOM   1990 H HD11 . LEU A 1 132 ? 24.83200  -24.50600 8.90100   1.000 20.58000  ? 132 LEU A HD11 1 
ATOM   1991 H HD12 . LEU A 1 132 ? 23.31700  -24.51000 8.42300   1.000 20.58000  ? 132 LEU A HD12 1 
ATOM   1992 H HD13 . LEU A 1 132 ? 23.80500  -23.45700 9.50700   1.000 20.58000  ? 132 LEU A HD13 1 
ATOM   1993 H HD21 . LEU A 1 132 ? 25.47700  -25.22300 11.06300  1.000 24.02000  ? 132 LEU A HD21 1 
ATOM   1994 H HD22 . LEU A 1 132 ? 24.44000  -24.30300 11.83800  1.000 24.02000  ? 132 LEU A HD22 1 
ATOM   1995 H HD23 . LEU A 1 132 ? 24.42600  -25.87600 12.05900  1.000 24.02000  ? 132 LEU A HD23 1 
ATOM   1996 N N    . VAL A 1 133 ? 19.17300  -26.09400 11.55600  1.000 18.20000  ? 133 VAL A N    1 
ATOM   1997 C CA   . VAL A 1 133 ? 17.87500  -25.54400 11.94100  1.000 16.95000  ? 133 VAL A CA   1 
ATOM   1998 C C    . VAL A 1 133 ? 16.84000  -26.62100 12.23200  1.000 17.60000  ? 133 VAL A C    1 
ATOM   1999 O O    . VAL A 1 133 ? 15.77800  -26.29900 12.75500  1.000 18.64000  ? 133 VAL A O    1 
ATOM   2000 C CB   . VAL A 1 133 ? 17.32400  -24.55800 10.89500  1.000 17.76000  ? 133 VAL A CB   1 
ATOM   2001 C CG1  . VAL A 1 133 ? 18.21300  -23.37400 10.71500  1.000 19.47000  ? 133 VAL A CG1  1 
ATOM   2002 C CG2  . VAL A 1 133 ? 17.08100  -25.27700 9.51900   1.000 17.88000  ? 133 VAL A CG2  1 
ATOM   2003 H H    . VAL A 1 133 ? 19.15100  -26.60700 10.86600  1.000 21.86000  ? 133 VAL A H    1 
ATOM   2004 H HA   . VAL A 1 133 ? 18.00500  -25.03800 12.75800  1.000 20.36000  ? 133 VAL A HA   1 
ATOM   2005 H HB   . VAL A 1 133 ? 16.47400  -24.23000 11.22600  1.000 21.33000  ? 133 VAL A HB   1 
ATOM   2006 H HG11 . VAL A 1 133 ? 17.78900  -22.75000 10.10600  1.000 23.39000  ? 133 VAL A HG11 1 
ATOM   2007 H HG12 . VAL A 1 133 ? 18.35400  -22.95100 11.57700  1.000 23.39000  ? 133 VAL A HG12 1 
ATOM   2008 H HG13 . VAL A 1 133 ? 19.06200  -23.66900 10.34800  1.000 23.39000  ? 133 VAL A HG13 1 
ATOM   2009 H HG21 . VAL A 1 133 ? 16.71700  -24.63600 8.88800   1.000 21.48000  ? 133 VAL A HG21 1 
ATOM   2010 H HG22 . VAL A 1 133 ? 17.92500  -25.62200 9.18900   1.000 21.48000  ? 133 VAL A HG22 1 
ATOM   2011 H HG23 . VAL A 1 133 ? 16.45300  -26.00500 9.65000   1.000 21.48000  ? 133 VAL A HG23 1 
ATOM   2012 N N    . ALA A 1 134 ? 17.12500  -27.89400 11.94800  1.000 17.27000  ? 134 ALA A N    1 
ATOM   2013 C CA   . ALA A 1 134 ? 16.14500  -28.96300 12.05200  1.000 16.55000  ? 134 ALA A CA   1 
ATOM   2014 C C    . ALA A 1 134 ? 16.75400  -30.09000 12.82800  1.000 18.96000  ? 134 ALA A C    1 
ATOM   2015 O O    . ALA A 1 134 ? 17.96400  -30.30300 12.76300  1.000 19.28000  ? 134 ALA A O    1 
ATOM   2016 C CB   . ALA A 1 134 ? 15.74000  -29.49400 10.66100  1.000 16.94000  ? 134 ALA A CB   1 
ATOM   2017 H H    . ALA A 1 134 ? 17.89900  -28.16400 11.68600  1.000 20.74000  ? 134 ALA A H    1 
ATOM   2018 H HA   . ALA A 1 134 ? 15.35200  -28.63700 12.50700  1.000 19.88000  ? 134 ALA A HA   1 
ATOM   2019 H HB1  . ALA A 1 134 ? 15.26900  -30.33500 10.76900  1.000 20.35000  ? 134 ALA A HB1  1 
ATOM   2020 H HB2  . ALA A 1 134 ? 15.16300  -28.84400 10.23100  1.000 20.35000  ? 134 ALA A HB2  1 
ATOM   2021 H HB3  . ALA A 1 134 ? 16.54000  -29.62900 10.13000  1.000 20.35000  ? 134 ALA A HB3  1 
ATOM   2022 N N    . ASP A 1 135 ? 15.92200  -30.85700 13.53100  1.000 19.86000  ? 135 ASP A N    1 
ATOM   2023 C CA   . ASP A 1 135 ? 16.47900  -32.01400 14.19100  1.000 19.46000  ? 135 ASP A CA   1 
ATOM   2024 C C    . ASP A 1 135 ? 16.05800  -33.32900 13.56800  1.000 24.11000  ? 135 ASP A C    1 
ATOM   2025 O O    . ASP A 1 135 ? 16.49200  -34.38200 14.02400  1.000 26.17000  ? 135 ASP A O    1 
ATOM   2026 C CB   . ASP A 1 135 ? 16.09300  -32.01400 15.67300  1.000 25.41000  ? 135 ASP A CB   1 
ATOM   2027 C CG   . ASP A 1 135 ? 14.65000  -31.83200 15.88000  1.000 35.33000  ? 135 ASP A CG   1 
ATOM   2028 O OD1  . ASP A 1 135 ? 13.85700  -32.08700 14.96600  1.000 47.19000  ? 135 ASP A OD1  1 
ATOM   2029 O OD2  . ASP A 1 135 ? 14.30700  -31.40000 17.01600  1.000 56.66000  ? 135 ASP A OD2  1 
ATOM   2030 H H    . ASP A 1 135 ? 15.07800  -30.72700 13.62900  1.000 23.85000  ? 135 ASP A H    1 
ATOM   2031 H HA   . ASP A 1 135 ? 17.44600  -31.95600 14.12700  1.000 23.38000  ? 135 ASP A HA   1 
ATOM   2032 H HB2  . ASP A 1 135 ? 16.34900  -32.86200 16.06700  1.000 30.52000  ? 135 ASP A HB2  1 
ATOM   2033 H HB3  . ASP A 1 135 ? 16.55400  -31.28800 16.12100  1.000 30.52000  ? 135 ASP A HB3  1 
ATOM   2034 N N    . HIS A 1 136 ? 15.25600  -33.29500 12.50600  1.000 19.39000  ? 136 HIS A N    1 
ATOM   2035 C CA   . HIS A 1 136 ? 14.68800  -34.46400 11.88100  1.000 21.11000  ? 136 HIS A CA   1 
ATOM   2036 C C    . HIS A 1 136 ? 14.34700  -34.00200 10.46500  1.000 17.51000  ? 136 HIS A C    1 
ATOM   2037 O O    . HIS A 1 136 ? 13.95200  -32.85000 10.26700  1.000 17.08000  ? 136 HIS A O    1 
ATOM   2038 C CB   . HIS A 1 136 ? 13.47400  -34.88100 12.72500  1.000 24.24000  ? 136 HIS A CB   1 
ATOM   2039 C CG   . HIS A 1 136 ? 12.68200  -35.99700 12.17000  1.000 30.37000  ? 136 HIS A CG   1 
ATOM   2040 N ND1  . HIS A 1 136 ? 11.31000  -35.96200 12.11100  1.000 44.63000  ? 136 HIS A ND1  1 
ATOM   2041 C CD2  . HIS A 1 136 ? 13.06700  -37.17800 11.63400  1.000 55.93000  ? 136 HIS A CD2  1 
ATOM   2042 C CE1  . HIS A 1 136 ? 10.88400  -37.06700 11.52700  1.000 46.62000  ? 136 HIS A CE1  1 
ATOM   2043 N NE2  . HIS A 1 136 ? 11.92600  -37.82800 11.24500  1.000 45.98000  ? 136 HIS A NE2  1 
ATOM   2044 H H    . HIS A 1 136 ? 15.01900  -32.56700 12.11600  1.000 23.29000  ? 136 HIS A H    1 
ATOM   2045 H HA   . HIS A 1 136 ? 15.26400  -35.24000 11.80300  1.000 25.36000  ? 136 HIS A HA   1 
ATOM   2046 H HB2  . HIS A 1 136 ? 13.78800  -35.15600 13.60100  1.000 29.11000  ? 136 HIS A HB2  1 
ATOM   2047 H HB3  . HIS A 1 136 ? 12.88100  -34.11800 12.81000  1.000 29.11000  ? 136 HIS A HB3  1 
ATOM   2048 H HD2  . HIS A 1 136 ? 13.93900  -37.48900 11.54700  1.000 67.14000  ? 136 HIS A HD2  1 
ATOM   2049 H HE1  . HIS A 1 136 ? 9.99600   -37.27500 11.34500  1.000 55.97000  ? 136 HIS A HE1  1 
ATOM   2050 H HE2  . HIS A 1 136 ? 11.89300  -38.60400 10.87600  1.000 55.19000  ? 136 HIS A HE2  1 
ATOM   2051 N N    . VAL A 1 137 ? 14.45600  -34.92000 9.49200   1.000 17.42000  ? 137 VAL A N    1 
ATOM   2052 C CA   . VAL A 1 137 ? 14.16000  -34.59500 8.11200   1.000 15.64000  ? 137 VAL A CA   1 
ATOM   2053 C C    . VAL A 1 137 ? 13.59600  -35.82300 7.43800   1.000 17.71000  ? 137 VAL A C    1 
ATOM   2054 O O    . VAL A 1 137 ? 14.01600  -36.94500 7.70700   1.000 17.76000  ? 137 VAL A O    1 
ATOM   2055 C CB   . VAL A 1 137 ? 15.39400  -34.09400 7.37000   1.000 17.40000  ? 137 VAL A CB   1 
ATOM   2056 C CG1  . VAL A 1 137 ? 16.57600  -35.05900 7.50600   1.000 21.54000  ? 137 VAL A CG1  1 
ATOM   2057 C CG2  . VAL A 1 137 ? 15.13100  -33.82300 5.90300   1.000 19.99000  ? 137 VAL A CG2  1 
ATOM   2058 H H    . VAL A 1 137 ? 14.70100  -35.73500 9.61900   1.000 20.92000  ? 137 VAL A H    1 
ATOM   2059 H HA   . VAL A 1 137 ? 13.48800  -33.89500 8.09900   1.000 18.78000  ? 137 VAL A HA   1 
ATOM   2060 H HB   . VAL A 1 137 ? 15.62900  -33.25200 7.78900   1.000 20.90000  ? 137 VAL A HB   1 
ATOM   2061 H HG11 . VAL A 1 137 ? 17.29100  -34.76700 6.92000   1.000 25.87000  ? 137 VAL A HG11 1 
ATOM   2062 H HG12 . VAL A 1 137 ? 16.88100  -35.05700 8.42700   1.000 25.87000  ? 137 VAL A HG12 1 
ATOM   2063 H HG13 . VAL A 1 137 ? 16.28600  -35.95000 7.25500   1.000 25.87000  ? 137 VAL A HG13 1 
ATOM   2064 H HG21 . VAL A 1 137 ? 15.86200  -33.29700 5.54300   1.000 24.00000  ? 137 VAL A HG21 1 
ATOM   2065 H HG22 . VAL A 1 137 ? 15.06900  -34.66900 5.43200   1.000 24.00000  ? 137 VAL A HG22 1 
ATOM   2066 H HG23 . VAL A 1 137 ? 14.29800  -33.33400 5.81700   1.000 24.00000  ? 137 VAL A HG23 1 
ATOM   2067 N N    . GLN A 1 138 ? 12.63000  -35.59800 6.55500   1.000 15.39000  ? 138 GLN A N    1 
ATOM   2068 C CA   . GLN A 1 138 ? 12.18100  -36.57700 5.55800   1.000 15.53000  ? 138 GLN A CA   1 
ATOM   2069 C C    . GLN A 1 138 ? 12.55200  -36.05800 4.16300   1.000 16.78000  ? 138 GLN A C    1 
ATOM   2070 O O    . GLN A 1 138 ? 12.34700  -34.87700 3.84600   1.000 17.14000  ? 138 GLN A O    1 
ATOM   2071 C CB   . GLN A 1 138 ? 10.67000  -36.75800 5.61400   1.000 16.44000  ? 138 GLN A CB   1 
ATOM   2072 C CG   . GLN A 1 138 ? 10.25600  -37.53100 6.81000   1.000 17.21000  ? 138 GLN A CG   1 
ATOM   2073 C CD   . GLN A 1 138 ? 8.78200   -37.39800 7.13900   1.000 22.16000  ? 138 GLN A CD   1 
ATOM   2074 O OE1  . GLN A 1 138 ? 8.02700   -36.76500 6.42800   1.000 24.18000  ? 138 GLN A OE1  1 
ATOM   2075 N NE2  . GLN A 1 138 ? 8.37700   -38.01900 8.26200   1.000 22.99000  ? 138 GLN A NE2  1 
ATOM   2076 H H    . GLN A 1 138 ? 12.19800  -34.85600 6.50900   1.000 18.48000  ? 138 GLN A H    1 
ATOM   2077 H HA   . GLN A 1 138 ? 12.60700  -37.43300 5.72300   1.000 18.65000  ? 138 GLN A HA   1 
ATOM   2078 H HB2  . GLN A 1 138 ? 10.24500  -35.88600 5.65200   1.000 19.75000  ? 138 GLN A HB2  1 
ATOM   2079 H HB3  . GLN A 1 138 ? 10.37600  -37.23700 4.82400   1.000 19.75000  ? 138 GLN A HB3  1 
ATOM   2080 H HG2  . GLN A 1 138 ? 10.44100  -38.47000 6.65400   1.000 20.67000  ? 138 GLN A HG2  1 
ATOM   2081 H HG3  . GLN A 1 138 ? 10.76000  -37.21600 7.57600   1.000 20.67000  ? 138 GLN A HG3  1 
ATOM   2082 H HE21 . GLN A 1 138 ? 8.94300   -38.45600 8.74000   1.000 27.61000  ? 138 GLN A HE21 1 
ATOM   2083 H HE22 . GLN A 1 138 ? 7.55200   -37.98000 8.50200   1.000 27.61000  ? 138 GLN A HE22 1 
ATOM   2084 N N    . VAL A 1 139 ? 13.08200  -36.92700 3.32600   1.000 14.39000  ? 139 VAL A N    1 
ATOM   2085 C CA   . VAL A 1 139 ? 13.36400  -36.61300 1.93000   1.000 14.06000  ? 139 VAL A CA   1 
ATOM   2086 C C    . VAL A 1 139 ? 12.43800  -37.48800 1.10800   1.000 15.32000  ? 139 VAL A C    1 
ATOM   2087 O O    . VAL A 1 139 ? 12.58600  -38.72900 1.09000   1.000 16.26000  ? 139 VAL A O    1 
ATOM   2088 C CB   . VAL A 1 139 ? 14.83000  -36.86200 1.54600   1.000 15.31000  ? 139 VAL A CB   1 
ATOM   2089 C CG1  . VAL A 1 139 ? 15.07200  -36.70900 0.07100   1.000 15.08000  ? 139 VAL A CG1  1 
ATOM   2090 C CG2  . VAL A 1 139 ? 15.79600  -35.96200 2.34300   1.000 16.23000  ? 139 VAL A CG2  1 
ATOM   2091 H H    . VAL A 1 139 ? 13.29500  -37.73100 3.54600   1.000 17.29000  ? 139 VAL A H    1 
ATOM   2092 H HA   . VAL A 1 139 ? 13.17300  -35.67600 1.76500   1.000 16.89000  ? 139 VAL A HA   1 
ATOM   2093 H HB   . VAL A 1 139 ? 15.02000  -37.78500 1.77800   1.000 18.39000  ? 139 VAL A HB   1 
ATOM   2094 H HG11 . VAL A 1 139 ? 16.01000  -36.50900 -0.07700  1.000 18.11000  ? 139 VAL A HG11 1 
ATOM   2095 H HG12 . VAL A 1 139 ? 14.83600  -37.53800 -0.37600  1.000 18.11000  ? 139 VAL A HG12 1 
ATOM   2096 H HG13 . VAL A 1 139 ? 14.52200  -35.98400 -0.26600  1.000 18.11000  ? 139 VAL A HG13 1 
ATOM   2097 H HG21 . VAL A 1 139 ? 16.70600  -36.15000 2.06400   1.000 19.50000  ? 139 VAL A HG21 1 
ATOM   2098 H HG22 . VAL A 1 139 ? 15.58100  -35.03300 2.16600   1.000 19.50000  ? 139 VAL A HG22 1 
ATOM   2099 H HG23 . VAL A 1 139 ? 15.69400  -36.15100 3.28900   1.000 19.50000  ? 139 VAL A HG23 1 
ATOM   2100 N N    . ILE A 1 140 ? 11.47000  -36.86200 0.46400   1.000 12.54000  ? 140 ILE A N    1 
ATOM   2101 C CA   . ILE A 1 140 ? 10.48600  -37.54900 -0.38500  1.000 13.83000  ? 140 ILE A CA   1 
ATOM   2102 C C    . ILE A 1 140 ? 10.95400  -37.36000 -1.82000  1.000 14.65000  ? 140 ILE A C    1 
ATOM   2103 O O    . ILE A 1 140 ? 11.27000  -36.24000 -2.21300  1.000 13.12000  ? 140 ILE A O    1 
ATOM   2104 C CB   . ILE A 1 140 ? 9.08900   -36.94900 -0.18900  1.000 14.82000  ? 140 ILE A CB   1 
ATOM   2105 C CG1  . ILE A 1 140 ? 8.66300   -37.00700 1.26400   1.000 15.57000  ? 140 ILE A CG1  1 
ATOM   2106 C CG2  . ILE A 1 140 ? 8.06600   -37.60400 -1.09500  1.000 16.02000  ? 140 ILE A CG2  1 
ATOM   2107 C CD1  . ILE A 1 140 ? 7.64800   -35.95600 1.63200   1.000 21.36000  ? 140 ILE A CD1  1 
ATOM   2108 H H    . ILE A 1 140 ? 11.35100  -36.01100 0.49700   1.000 15.07000  ? 140 ILE A H    1 
ATOM   2109 H HA   . ILE A 1 140 ? 10.44400  -38.49500 -0.17100  1.000 16.61000  ? 140 ILE A HA   1 
ATOM   2110 H HB   . ILE A 1 140 ? 9.14200   -36.01400 -0.44200  1.000 17.80000  ? 140 ILE A HB   1 
ATOM   2111 H HG12 . ILE A 1 140 ? 8.27000   -37.87600 1.44000   1.000 18.71000  ? 140 ILE A HG12 1 
ATOM   2112 H HG13 . ILE A 1 140 ? 9.44400   -36.87600 1.82400   1.000 18.71000  ? 140 ILE A HG13 1 
ATOM   2113 H HG21 . ILE A 1 140 ? 7.17600   -37.39800 -0.76800  1.000 19.24000  ? 140 ILE A HG21 1 
ATOM   2114 H HG22 . ILE A 1 140 ? 8.17500   -37.26100 -1.99600  1.000 19.24000  ? 140 ILE A HG22 1 
ATOM   2115 H HG23 . ILE A 1 140 ? 8.20600   -38.56400 -1.08800  1.000 19.24000  ? 140 ILE A HG23 1 
ATOM   2116 H HD11 . ILE A 1 140 ? 7.51200   -35.97200 2.59300   1.000 25.65000  ? 140 ILE A HD11 1 
ATOM   2117 H HD12 . ILE A 1 140 ? 7.98000   -35.08700 1.36000   1.000 25.65000  ? 140 ILE A HD12 1 
ATOM   2118 H HD13 . ILE A 1 140 ? 6.81400   -36.15000 1.17700   1.000 25.65000  ? 140 ILE A HD13 1 
ATOM   2119 N N    . SER A 1 141 ? 11.03000  -38.43500 -2.61800  1.000 13.68000  ? 141 SER A N    1 
ATOM   2120 C CA   . SER A 1 141 ? 11.55300  -38.26600 -3.97500  1.000 13.07000  ? 141 SER A CA   1 
ATOM   2121 C C    . SER A 1 141 ? 10.91600  -39.21500 -4.97000  1.000 13.33000  ? 141 SER A C    1 
ATOM   2122 O O    . SER A 1 141 ? 10.54600  -40.34400 -4.62100  1.000 15.06000  ? 141 SER A O    1 
ATOM   2123 C CB   . SER A 1 141 ? 13.10400  -38.44200 -4.03000  1.000 14.01000  ? 141 SER A CB   1 
ATOM   2124 O OG   . SER A 1 141 ? 13.67000  -37.82600 -5.13700  1.000 14.96000  ? 141 SER A OG   1 
ATOM   2125 H H    . SER A 1 141 ? 10.79500  -39.23400 -2.40300  1.000 16.43000  ? 141 SER A H    1 
ATOM   2126 H HA   . SER A 1 141 ? 11.30800  -37.36900 -4.24900  1.000 15.70000  ? 141 SER A HA   1 
ATOM   2127 H HB2  . SER A 1 141 ? 13.48800  -38.05200 -3.22900  1.000 16.83000  ? 141 SER A HB2  1 
ATOM   2128 H HB3  . SER A 1 141 ? 13.30600  -39.39000 -4.06700  1.000 16.83000  ? 141 SER A HB3  1 
ATOM   2129 H HG   . SER A 1 141 ? 13.06800  -37.49700 -5.62200  1.000 17.98000  ? 141 SER A HG   1 
ATOM   2130 N N    . LYS A 1 142 ? 10.80500  -38.70600 -6.18900  1.000 14.35000  ? 142 LYS A N    1 
ATOM   2131 C CA   . LYS A 1 142 ? 10.19300  -39.42800 -7.30700  1.000 15.30000  ? 142 LYS A CA   1 
ATOM   2132 C C    . LYS A 1 142 ? 11.04600  -39.13400 -8.53200  1.000 13.58000  ? 142 LYS A C    1 
ATOM   2133 O O    . LYS A 1 142 ? 11.06200  -38.01400 -9.07000  1.000 15.74000  ? 142 LYS A O    1 
ATOM   2134 C CB   . LYS A 1 142 ? 8.75800   -38.98100 -7.55800  1.000 14.25000  ? 142 LYS A CB   1 
ATOM   2135 C CG   . LYS A 1 142 ? 8.08100   -39.64800 -8.73500  1.000 16.76000  ? 142 LYS A CG   1 
ATOM   2136 C CD   . LYS A 1 142 ? 7.87500   -41.08900 -8.54800  1.000 16.16000  ? 142 LYS A CD   1 
ATOM   2137 C CE   . LYS A 1 142 ? 7.13400   -41.71500 -9.73600  1.000 16.71000  ? 142 LYS A CE   1 
ATOM   2138 N NZ   . LYS A 1 142 ? 7.93800   -41.83200 -10.96600 1.000 18.76000  ? 142 LYS A NZ   1 
ATOM   2139 H H    . LYS A 1 142 ? 11.08400  -37.92100 -6.40500  1.000 17.24000  ? 142 LYS A H    1 
ATOM   2140 H HA   . LYS A 1 142 ? 10.17700  -40.37900 -7.12100  1.000 18.38000  ? 142 LYS A HA   1 
ATOM   2141 H HB2  . LYS A 1 142 ? 8.23200   -39.17900 -6.76800  1.000 17.12000  ? 142 LYS A HB2  1 
ATOM   2142 H HB3  . LYS A 1 142 ? 8.75800   -38.02500 -7.72500  1.000 17.12000  ? 142 LYS A HB3  1 
ATOM   2143 H HG2  . LYS A 1 142 ? 7.21200   -39.23900 -8.87100  1.000 20.13000  ? 142 LYS A HG2  1 
ATOM   2144 H HG3  . LYS A 1 142 ? 8.63200   -39.52700 -9.52500  1.000 20.13000  ? 142 LYS A HG3  1 
ATOM   2145 H HD2  . LYS A 1 142 ? 8.73600   -41.52700 -8.46200  1.000 19.41000  ? 142 LYS A HD2  1 
ATOM   2146 H HD3  . LYS A 1 142 ? 7.34600   -41.23600 -7.74800  1.000 19.41000  ? 142 LYS A HD3  1 
ATOM   2147 H HE2  . LYS A 1 142 ? 6.84900   -42.60800 -9.48700  1.000 20.07000  ? 142 LYS A HE2  1 
ATOM   2148 H HE3  . LYS A 1 142 ? 6.36100   -41.16600 -9.94400  1.000 20.07000  ? 142 LYS A HE3  1 
ATOM   2149 H HZ1  . LYS A 1 142 ? 8.13400   -41.02300 -11.28000 1.000 22.54000  ? 142 LYS A HZ1  1 
ATOM   2150 H HZ2  . LYS A 1 142 ? 8.69500   -42.26700 -10.79400 1.000 22.54000  ? 142 LYS A HZ2  1 
ATOM   2151 H HZ3  . LYS A 1 142 ? 7.48300   -42.27900 -11.58600 1.000 22.54000  ? 142 LYS A HZ3  1 
ATOM   2152 N N    . HIS A 1 143 ? 11.64500  -40.21400 -9.06100  1.000 14.84000  ? 143 HIS A N    1 
ATOM   2153 C CA   . HIS A 1 143 ? 12.44600  -40.19800 -10.27600 1.000 14.42000  ? 143 HIS A CA   1 
ATOM   2154 C C    . HIS A 1 143 ? 11.64800  -40.90700 -11.37400 1.000 17.59000  ? 143 HIS A C    1 
ATOM   2155 O O    . HIS A 1 143 ? 10.85800  -41.78000 -11.03100 1.000 16.19000  ? 143 HIS A O    1 
ATOM   2156 C CB   . HIS A 1 143 ? 13.72600  -40.96100 -10.03000 1.000 16.75000  ? 143 HIS A CB   1 
ATOM   2157 C CG   . HIS A 1 143 ? 14.74000  -40.87100 -11.13700 1.000 17.81000  ? 143 HIS A CG   1 
ATOM   2158 N ND1  . HIS A 1 143 ? 14.65100  -41.64000 -12.28600 1.000 19.32000  ? 143 HIS A ND1  1 
ATOM   2159 C CD2  . HIS A 1 143 ? 15.91900  -40.21600 -11.21000 1.000 18.34000  ? 143 HIS A CD2  1 
ATOM   2160 C CE1  . HIS A 1 143 ? 15.69200  -41.36900 -13.06800 1.000 19.66000  ? 143 HIS A CE1  1 
ATOM   2161 N NE2  . HIS A 1 143 ? 16.50100  -40.54500 -12.42300 1.000 19.59000  ? 143 HIS A NE2  1 
ATOM   2162 H H    . HIS A 1 143 ? 11.59500  -40.99700 -8.71000  1.000 17.82000  ? 143 HIS A H    1 
ATOM   2163 H HA   . HIS A 1 143 ? 12.65800  -39.29500 -10.56000 1.000 17.32000  ? 143 HIS A HA   1 
ATOM   2164 H HB2  . HIS A 1 143 ? 14.14100  -40.61200 -9.22600  1.000 20.12000  ? 143 HIS A HB2  1 
ATOM   2165 H HB3  . HIS A 1 143 ? 13.50700  -41.89800 -9.91200  1.000 20.12000  ? 143 HIS A HB3  1 
ATOM   2166 H HD2  . HIS A 1 143 ? 16.27500  -39.64800 -10.56400 1.000 22.02000  ? 143 HIS A HD2  1 
ATOM   2167 H HE1  . HIS A 1 143 ? 15.82800  -41.70300 -13.92600 1.000 23.62000  ? 143 HIS A HE1  1 
ATOM   2168 H HE2  . HIS A 1 143 ? 17.26100  -40.26100 -12.70900 1.000 23.53000  ? 143 HIS A HE2  1 
ATOM   2169 N N    . ASN A 1 144 ? 11.84200  -40.51400 -12.64200 1.000 17.64000  ? 144 ASN A N    1 
ATOM   2170 C CA   . ASN A 1 144 ? 11.01500  -41.13300 -13.69800 1.000 16.92000  ? 144 ASN A CA   1 
ATOM   2171 C C    . ASN A 1 144 ? 11.20300  -42.63600 -13.75400 1.000 21.23000  ? 144 ASN A C    1 
ATOM   2172 O O    . ASN A 1 144 ? 10.27000  -43.32900 -14.23300 1.000 23.01000  ? 144 ASN A O    1 
ATOM   2173 C CB   . ASN A 1 144 ? 11.36900  -40.49100 -15.05500 1.000 17.00000  ? 144 ASN A CB   1 
ATOM   2174 C CG   . ASN A 1 144 ? 10.78200  -39.11700 -15.27200 1.000 18.16000  ? 144 ASN A CG   1 
ATOM   2175 O OD1  . ASN A 1 144 ? 9.85800   -38.66400 -14.55700 1.000 18.27000  ? 144 ASN A OD1  1 
ATOM   2176 N ND2  . ASN A 1 144 ? 11.32100  -38.41700 -16.29900 1.000 19.90000  ? 144 ASN A ND2  1 
ATOM   2177 H H    . ASN A 1 144 ? 12.41200  -39.92500 -12.90500 1.000 21.18000  ? 144 ASN A H    1 
ATOM   2178 H HA   . ASN A 1 144 ? 10.07600  -40.96600 -13.52100 1.000 20.32000  ? 144 ASN A HA   1 
ATOM   2179 H HB2  . ASN A 1 144 ? 12.33400  -40.40900 -15.11600 1.000 20.42000  ? 144 ASN A HB2  1 
ATOM   2180 H HB3  . ASN A 1 144 ? 11.04000  -41.06500 -15.76400 1.000 20.42000  ? 144 ASN A HB3  1 
ATOM   2181 H HD21 . ASN A 1 144 ? 11.03300  -37.62700 -16.47900 1.000 23.90000  ? 144 ASN A HD21 1 
ATOM   2182 H HD22 . ASN A 1 144 ? 11.95000  -38.76300 -16.77200 1.000 23.90000  ? 144 ASN A HD22 1 
ATOM   2183 N N    . ASP A 1 145 ? 12.33800  -43.15300 -13.27000 1.000 18.22000  ? 145 ASP A N    1 
ATOM   2184 C CA   . ASP A 1 145 ? 12.62800  -44.60500 -13.33300 1.000 20.40000  ? 145 ASP A CA   1 
ATOM   2185 C C    . ASP A 1 145 ? 12.10300  -45.40700 -12.12100 1.000 25.21000  ? 145 ASP A C    1 
ATOM   2186 O O    . ASP A 1 145 ? 12.30500  -46.62300 -12.07800 1.000 24.15000  ? 145 ASP A O    1 
ATOM   2187 C CB   . ASP A 1 145 ? 14.13500  -44.89400 -13.45500 1.000 22.89000  ? 145 ASP A CB   1 
ATOM   2188 C CG   . ASP A 1 145 ? 14.73000  -44.46200 -14.79200 1.000 24.34000  ? 145 ASP A CG   1 
ATOM   2189 O OD1  . ASP A 1 145 ? 13.96700  -44.21900 -15.75200 1.000 26.11000  ? 145 ASP A OD1  1 
ATOM   2190 O OD2  . ASP A 1 145 ? 15.99300  -44.33000 -14.82700 1.000 25.61000  ? 145 ASP A OD2  1 
ATOM   2191 H H    . ASP A 1 145 ? 12.96000  -42.68900 -12.89900 1.000 21.88000  ? 145 ASP A H    1 
ATOM   2192 H HA   . ASP A 1 145 ? 12.18900  -44.92100 -14.13800 1.000 24.50000  ? 145 ASP A HA   1 
ATOM   2193 H HB2  . ASP A 1 145 ? 14.60400  -44.41600 -12.75300 1.000 27.49000  ? 145 ASP A HB2  1 
ATOM   2194 H HB3  . ASP A 1 145 ? 14.28000  -45.84900 -13.36000 1.000 27.49000  ? 145 ASP A HB3  1 
ATOM   2195 N N    . ASP A 1 146 ? 11.48100  -44.79400 -11.09400 1.000 18.89000  ? 146 ASP A N    1 
ATOM   2196 C CA   . ASP A 1 146 ? 11.09600  -45.55500 -9.93400  1.000 16.12000  ? 146 ASP A CA   1 
ATOM   2197 C C    . ASP A 1 146 ? 9.78800   -44.98800 -9.34400  1.000 17.91000  ? 146 ASP A C    1 
ATOM   2198 O O    . ASP A 1 146 ? 9.22500   -43.99500 -9.82100  1.000 20.91000  ? 146 ASP A O    1 
ATOM   2199 C CB   . ASP A 1 146 ? 12.20300  -45.53600 -8.87400  1.000 20.92000  ? 146 ASP A CB   1 
ATOM   2200 C CG   . ASP A 1 146 ? 12.24400  -46.72500 -7.95600  1.000 19.59000  ? 146 ASP A CG   1 
ATOM   2201 O OD1  . ASP A 1 146 ? 11.35600  -47.61400 -7.96800  1.000 21.46000  ? 146 ASP A OD1  1 
ATOM   2202 O OD2  . ASP A 1 146 ? 13.18200  -46.75100 -7.10800  1.000 22.61000  ? 146 ASP A OD2  1 
ATOM   2203 H H    A ASP A 1 146 ? 11.28400  -43.95800 -11.06500 0.720 22.69000  ? 146 ASP A H    1 
ATOM   2204 H H    B ASP A 1 146 ? 11.28400  -43.95800 -11.06500 0.280 22.69000  ? 146 ASP A H    1 
ATOM   2205 H HA   . ASP A 1 146 ? 10.93100  -46.46600 -10.22200 1.000 19.37000  ? 146 ASP A HA   1 
ATOM   2206 H HB2  . ASP A 1 146 ? 13.05900  -45.49300 -9.32800  1.000 25.12000  ? 146 ASP A HB2  1 
ATOM   2207 H HB3  . ASP A 1 146 ? 12.08200  -44.74900 -8.32000  1.000 25.12000  ? 146 ASP A HB3  1 
ATOM   2208 N N    . GLU A 1 147 ? 9.30900   -45.65700 -8.30800  1.000 18.54000  ? 147 GLU A N    1 
ATOM   2209 C CA   . GLU A 1 147 ? 8.17400   -45.21000 -7.50900  1.000 19.22000  ? 147 GLU A CA   1 
ATOM   2210 C C    . GLU A 1 147 ? 8.64100   -44.07900 -6.59500  1.000 17.43000  ? 147 GLU A C    1 
ATOM   2211 O O    . GLU A 1 147 ? 9.84400   -43.89000 -6.38500  1.000 18.32000  ? 147 GLU A O    1 
ATOM   2212 C CB   . GLU A 1 147 ? 7.63300   -46.32700 -6.65100  1.000 21.45000  ? 147 GLU A CB   1 
ATOM   2213 C CG   . GLU A 1 147 ? 7.21900   -47.57300 -7.47300  1.000 30.25000  ? 147 GLU A CG   1 
ATOM   2214 C CD   . GLU A 1 147 ? 6.15100   -47.27200 -8.49000  1.000 36.95000  ? 147 GLU A CD   1 
ATOM   2215 O OE1  . GLU A 1 147 ? 5.28300   -46.41800 -8.24700  1.000 49.65000  ? 147 GLU A OE1  1 
ATOM   2216 O OE2  . GLU A 1 147 ? 6.18300   -47.91200 -9.56400  1.000 53.21000  ? 147 GLU A OE2  1 
ATOM   2217 H H    . GLU A 1 147 ? 9.63400   -46.40500 -8.03400  1.000 22.27000  ? 147 GLU A H    1 
ATOM   2218 H HA   . GLU A 1 147 ? 7.46500   -44.91200 -8.10000  1.000 23.08000  ? 147 GLU A HA   1 
ATOM   2219 H HB2  . GLU A 1 147 ? 8.31700   -46.59800 -6.01900  1.000 25.76000  ? 147 GLU A HB2  1 
ATOM   2220 H HB3  . GLU A 1 147 ? 6.85000   -46.00700 -6.17600  1.000 25.76000  ? 147 GLU A HB3  1 
ATOM   2221 H HG2  . GLU A 1 147 ? 7.99500   -47.91200 -7.94500  1.000 36.32000  ? 147 GLU A HG2  1 
ATOM   2222 H HG3  . GLU A 1 147 ? 6.87500   -48.25000 -6.86900  1.000 36.32000  ? 147 GLU A HG3  1 
ATOM   2223 N N    . GLN A 1 148 ? 7.67800   -43.46700 -5.90400  1.000 17.01000  ? 148 GLN A N    1 
ATOM   2224 C CA   . GLN A 1 148 ? 7.99500   -42.45600 -4.91900  1.000 13.67000  ? 148 GLN A CA   1 
ATOM   2225 C C    . GLN A 1 148 ? 8.37500   -43.10900 -3.60700  1.000 14.44000  ? 148 GLN A C    1 
ATOM   2226 O O    . GLN A 1 148 ? 7.71200   -44.05700 -3.12600  1.000 16.31000  ? 148 GLN A O    1 
ATOM   2227 C CB   . GLN A 1 148 ? 6.80200   -41.51900 -4.72300  1.000 15.12000  ? 148 GLN A CB   1 
ATOM   2228 C CG   . GLN A 1 148 ? 6.98300   -40.31900 -3.76400  1.000 14.37000  ? 148 GLN A CG   1 
ATOM   2229 C CD   . GLN A 1 148 ? 5.93400   -39.28400 -3.96000  1.000 13.95000  ? 148 GLN A CD   1 
ATOM   2230 O OE1  . GLN A 1 148 ? 5.61500   -38.83900 -5.04600  1.000 15.83000  ? 148 GLN A OE1  1 
ATOM   2231 N NE2  . GLN A 1 148 ? 5.37500   -38.88200 -2.84200  1.000 15.41000  ? 148 GLN A NE2  1 
ATOM   2232 H H    . GLN A 1 148 ? 6.83700   -43.62500 -5.99200  1.000 20.43000  ? 148 GLN A H    1 
ATOM   2233 H HA   . GLN A 1 148 ? 8.74900   -41.92900 -5.22600  1.000 16.42000  ? 148 GLN A HA   1 
ATOM   2234 H HB2  . GLN A 1 148 ? 6.56800   -41.15100 -5.58900  1.000 18.17000  ? 148 GLN A HB2  1 
ATOM   2235 H HB3  . GLN A 1 148 ? 6.06500   -42.04500 -4.37500  1.000 18.17000  ? 148 GLN A HB3  1 
ATOM   2236 H HG2  . GLN A 1 148 ? 6.93300   -40.63200 -2.84800  1.000 17.26000  ? 148 GLN A HG2  1 
ATOM   2237 H HG3  . GLN A 1 148 ? 7.84700   -39.90800 -3.92700  1.000 17.26000  ? 148 GLN A HG3  1 
ATOM   2238 H HE21 . GLN A 1 148 ? 5.62600   -39.21700 -2.09100  1.000 18.51000  ? 148 GLN A HE21 1 
ATOM   2239 H HE22 . GLN A 1 148 ? 4.75600   -38.28500 -2.86100  1.000 18.51000  ? 148 GLN A HE22 1 
ATOM   2240 N N    . TYR A 1 149 ? 9.45900   -42.61100 -2.98900  1.000 15.47000  ? 149 TYR A N    1 
ATOM   2241 C CA   . TYR A 1 149 ? 10.01600  -43.13700 -1.78000  1.000 14.59000  ? 149 TYR A CA   1 
ATOM   2242 C C    . TYR A 1 149 ? 10.26200  -42.01200 -0.76600  1.000 15.62000  ? 149 TYR A C    1 
ATOM   2243 O O    . TYR A 1 149 ? 10.43500  -40.85600 -1.16400  1.000 16.46000  ? 149 TYR A O    1 
ATOM   2244 C CB   . TYR A 1 149 ? 11.39700  -43.87300 -2.02600  1.000 15.28000  ? 149 TYR A CB   1 
ATOM   2245 C CG   . TYR A 1 149 ? 11.19400  -45.29700 -2.54000  1.000 17.08000  ? 149 TYR A CG   1 
ATOM   2246 C CD1  . TYR A 1 149 ? 11.08200  -45.51200 -3.87100  1.000 18.35000  ? 149 TYR A CD1  1 
ATOM   2247 C CD2  . TYR A 1 149 ? 11.08800  -46.34800 -1.67000  1.000 17.57000  ? 149 TYR A CD2  1 
ATOM   2248 C CE1  . TYR A 1 149 ? 10.79600  -46.79700 -4.37400  1.000 19.10000  ? 149 TYR A CE1  1 
ATOM   2249 C CE2  . TYR A 1 149 ? 10.84200  -47.65400 -2.17100  1.000 18.92000  ? 149 TYR A CE2  1 
ATOM   2250 C CZ   . TYR A 1 149 ? 10.70500  -47.80500 -3.47700  1.000 17.71000  ? 149 TYR A CZ   1 
ATOM   2251 O OH   . TYR A 1 149 ? 10.45400  -49.12800 -3.94900  1.000 25.36000  ? 149 TYR A OH   1 
ATOM   2252 H H    . TYR A 1 149 ? 9.89800   -41.93300 -3.28500  1.000 18.59000  ? 149 TYR A H    1 
ATOM   2253 H HA   . TYR A 1 149 ? 9.37400   -43.76400 -1.41300  1.000 17.53000  ? 149 TYR A HA   1 
ATOM   2254 H HB2  . TYR A 1 149 ? 11.90900  -43.38000 -2.68600  1.000 18.36000  ? 149 TYR A HB2  1 
ATOM   2255 H HB3  . TYR A 1 149 ? 11.88900  -43.91700 -1.19100  1.000 18.36000  ? 149 TYR A HB3  1 
ATOM   2256 H HD1  . TYR A 1 149 ? 11.19700  -44.80300 -4.46100  1.000 22.04000  ? 149 TYR A HD1  1 
ATOM   2257 H HD2  . TYR A 1 149 ? 11.17700  -46.20800 -0.75400  1.000 21.11000  ? 149 TYR A HD2  1 
ATOM   2258 H HE1  . TYR A 1 149 ? 10.67500  -46.94600 -5.28400  1.000 22.94000  ? 149 TYR A HE1  1 
ATOM   2259 H HE2  . TYR A 1 149 ? 10.78000  -48.38300 -1.59700  1.000 22.72000  ? 149 TYR A HE2  1 
ATOM   2260 H HH   . TYR A 1 149 ? 10.56400  -49.68100 -3.32700  1.000 30.46000  ? 149 TYR A HH   1 
ATOM   2261 N N    . VAL A 1 150 ? 10.31500  -42.39000 0.50800   1.000 14.35000  ? 150 VAL A N    1 
ATOM   2262 C CA   . VAL A 1 150 ? 10.64300  -41.48700 1.60400   1.000 15.23000  ? 150 VAL A CA   1 
ATOM   2263 C C    . VAL A 1 150 ? 11.87300  -42.01400 2.35300   1.000 17.08000  ? 150 VAL A C    1 
ATOM   2264 O O    . VAL A 1 150 ? 11.87800  -43.15100 2.89000   1.000 18.13000  ? 150 VAL A O    1 
ATOM   2265 C CB   . VAL A 1 150 ? 9.47300   -41.29600 2.58500   1.000 19.84000  ? 150 VAL A CB   1 
ATOM   2266 C CG1  . VAL A 1 150 ? 9.82000   -40.16800 3.61200   1.000 20.95000  ? 150 VAL A CG1  1 
ATOM   2267 C CG2  . VAL A 1 150 ? 8.23800   -41.02500 1.90200   1.000 24.24000  ? 150 VAL A CG2  1 
ATOM   2268 H H    . VAL A 1 150 ? 10.15800  -43.19300 0.77100   1.000 17.24000  ? 150 VAL A H    1 
ATOM   2269 H HA   . VAL A 1 150 ? 10.87200  -40.62900 1.21300   1.000 18.30000  ? 150 VAL A HA   1 
ATOM   2270 H HB   . VAL A 1 150 ? 9.33800   -42.12400 3.07100   1.000 23.83000  ? 150 VAL A HB   1 
ATOM   2271 H HG11 . VAL A 1 150 ? 9.04000   -39.99000 4.16100   1.000 25.17000  ? 150 VAL A HG11 1 
ATOM   2272 H HG12 . VAL A 1 150 ? 10.55600  -40.46400 4.17000   1.000 25.17000  ? 150 VAL A HG12 1 
ATOM   2273 H HG13 . VAL A 1 150 ? 10.07300  -39.36700 3.12800   1.000 25.17000  ? 150 VAL A HG13 1 
ATOM   2274 H HG21 . VAL A 1 150 ? 7.61200   -40.62800 2.52700   1.000 29.11000  ? 150 VAL A HG21 1 
ATOM   2275 H HG22 . VAL A 1 150 ? 8.40900   -40.41200 1.17000   1.000 29.11000  ? 150 VAL A HG22 1 
ATOM   2276 H HG23 . VAL A 1 150 ? 7.87800   -41.85800 1.55800   1.000 29.11000  ? 150 VAL A HG23 1 
ATOM   2277 N N    . TRP A 1 151 ? 12.87600  -41.15200 2.43900   1.000 14.58000  ? 151 TRP A N    1 
ATOM   2278 C CA   . TRP A 1 151 ? 14.10800  -41.39600 3.21000   1.000 15.48000  ? 151 TRP A CA   1 
ATOM   2279 C C    . TRP A 1 151 ? 13.93200  -40.61000 4.50600   1.000 17.81000  ? 151 TRP A C    1 
ATOM   2280 O O    . TRP A 1 151 ? 13.39900  -39.55700 4.44000   1.000 18.46000  ? 151 TRP A O    1 
ATOM   2281 C CB   . TRP A 1 151 ? 15.29900  -40.91000 2.38300   1.000 15.74000  ? 151 TRP A CB   1 
ATOM   2282 C CG   . TRP A 1 151 ? 16.65700  -40.93800 3.00900   1.000 16.07000  ? 151 TRP A CG   1 
ATOM   2283 C CD1  . TRP A 1 151 ? 17.65400  -41.83400 2.75400   1.000 20.94000  ? 151 TRP A CD1  1 
ATOM   2284 C CD2  . TRP A 1 151 ? 17.21900  -39.95600 3.89400   1.000 18.97000  ? 151 TRP A CD2  1 
ATOM   2285 N NE1  . TRP A 1 151 ? 18.77900  -41.50600 3.45900   1.000 24.33000  ? 151 TRP A NE1  1 
ATOM   2286 C CE2  . TRP A 1 151 ? 18.54200  -40.35900 4.16800   1.000 25.34000  ? 151 TRP A CE2  1 
ATOM   2287 C CE3  . TRP A 1 151 ? 16.72800  -38.79800 4.50100   1.000 20.55000  ? 151 TRP A CE3  1 
ATOM   2288 C CZ2  . TRP A 1 151 ? 19.37500  -39.63900 5.02000   1.000 26.19000  ? 151 TRP A CZ2  1 
ATOM   2289 C CZ3  . TRP A 1 151 ? 17.55200  -38.08900 5.34500   1.000 24.54000  ? 151 TRP A CZ3  1 
ATOM   2290 C CH2  . TRP A 1 151 ? 18.85800  -38.50500 5.59700   1.000 27.83000  ? 151 TRP A CH2  1 
ATOM   2291 H H    . TRP A 1 151 ? 12.87200  -40.23000 1.97500   1.000 17.51000  ? 151 TRP A H    1 
ATOM   2292 H HA   . TRP A 1 151 ? 14.20600  -42.46000 3.40200   1.000 18.59000  ? 151 TRP A HA   1 
ATOM   2293 H HB2  . TRP A 1 151 ? 15.33200  -41.51100 1.47500   1.000 18.91000  ? 151 TRP A HB2  1 
ATOM   2294 H HB3  . TRP A 1 151 ? 15.08700  -39.88600 2.08100   1.000 18.91000  ? 151 TRP A HB3  1 
ATOM   2295 H HD1  . TRP A 1 151 ? 17.56400  -42.70100 2.11300   1.000 25.15000  ? 151 TRP A HD1  1 
ATOM   2296 H HE1  . TRP A 1 151 ? 19.64500  -42.03600 3.46100   1.000 29.22000  ? 151 TRP A HE1  1 
ATOM   2297 H HE3  . TRP A 1 151 ? 15.71900  -38.46100 4.30400   1.000 24.69000  ? 151 TRP A HE3  1 
ATOM   2298 H HZ2  . TRP A 1 151 ? 20.38500  -39.96700 5.22200   1.000 31.45000  ? 151 TRP A HZ2  1 
ATOM   2299 H HZ3  . TRP A 1 151 ? 17.18200  -37.18900 5.81500   1.000 29.47000  ? 151 TRP A HZ3  1 
ATOM   2300 H HH2  . TRP A 1 151 ? 19.47700  -37.92700 6.27000   1.000 33.42000  ? 151 TRP A HH2  1 
ATOM   2301 N N    . GLU A 1 152 ? 14.25400  -41.15000 5.65600   1.000 16.60000  ? 152 GLU A N    1 
ATOM   2302 C CA   . GLU A 1 152 ? 14.00700  -40.42200 6.89800   1.000 19.28000  ? 152 GLU A CA   1 
ATOM   2303 C C    . GLU A 1 152 ? 15.16500  -40.57000 7.86700   1.000 24.11000  ? 152 GLU A C    1 
ATOM   2304 O O    . GLU A 1 152 ? 15.69900  -41.67600 8.01500   1.000 23.56000  ? 152 GLU A O    1 
ATOM   2305 C CB   . GLU A 1 152 ? 12.67900  -40.86300 7.57300   1.000 19.83000  ? 152 GLU A CB   1 
ATOM   2306 C CG   . GLU A 1 152 ? 12.23400  -39.97900 8.73300   1.000 21.79000  ? 152 GLU A CG   1 
ATOM   2307 C CD   . GLU A 1 152 ? 10.87000  -40.26800 9.24300   1.000 26.28000  ? 152 GLU A CD   1 
ATOM   2308 O OE1  . GLU A 1 152 ? 10.25200  -41.27900 8.84300   1.000 34.65000  ? 152 GLU A OE1  1 
ATOM   2309 O OE2  . GLU A 1 152 ? 10.33200  -39.43600 9.96400   1.000 26.90000  ? 152 GLU A OE2  1 
ATOM   2310 H H    . GLU A 1 152 ? 14.61300  -41.92700 5.74300   1.000 19.94000  ? 152 GLU A H    1 
ATOM   2311 H HA   . GLU A 1 152 ? 13.94400  -39.47800 6.68400   1.000 23.15000  ? 152 GLU A HA   1 
ATOM   2312 H HB2  . GLU A 1 152 ? 11.97500  -40.84900 6.90700   1.000 23.81000  ? 152 GLU A HB2  1 
ATOM   2313 H HB3  . GLU A 1 152 ? 12.79200  -41.76300 7.91800   1.000 23.81000  ? 152 GLU A HB3  1 
ATOM   2314 H HG2  . GLU A 1 152 ? 12.85300  -40.10200 9.47000   1.000 26.17000  ? 152 GLU A HG2  1 
ATOM   2315 H HG3  . GLU A 1 152 ? 12.24600  -39.05500 8.43900   1.000 26.17000  ? 152 GLU A HG3  1 
ATOM   2316 N N    . SER A 1 153 ? 15.53300  -39.46000 8.52500   1.000 23.52000  ? 153 SER A N    1 
ATOM   2317 C CA   . SER A 1 153 ? 16.62200  -39.52000 9.50300   1.000 28.19000  ? 153 SER A CA   1 
ATOM   2318 C C    . SER A 1 153 ? 16.40400  -38.56200 10.66800  1.000 38.63000  ? 153 SER A C    1 
ATOM   2319 O O    . SER A 1 153 ? 15.88600  -37.44600 10.50200  1.000 26.28000  ? 153 SER A O    1 
ATOM   2320 C CB   . SER A 1 153 ? 17.97700  -39.16000 8.86900   1.000 39.98000  ? 153 SER A CB   1 
ATOM   2321 O OG   . SER A 1 153 ? 18.98400  -39.12400 9.88300   1.000 50.64000  ? 153 SER A OG   1 
ATOM   2322 H H    . SER A 1 153 ? 15.17600  -38.68400 8.42300   1.000 28.24000  ? 153 SER A H    1 
ATOM   2323 H HA   . SER A 1 153 ? 16.62300  -40.42600 9.85100   1.000 33.85000  ? 153 SER A HA   1 
ATOM   2324 H HB2  . SER A 1 153 ? 18.21000  -39.83100 8.20800   1.000 47.99000  ? 153 SER A HB2  1 
ATOM   2325 H HB3  . SER A 1 153 ? 17.91300  -38.28800 8.44900   1.000 47.99000  ? 153 SER A HB3  1 
ATOM   2326 H HG   . SER A 1 153 ? 19.73800  -39.00000 9.53400   1.000 60.79000  ? 153 SER A HG   1 
ATOM   2327 N N    . ASN A 1 154 ? 16.90200  -38.96600 11.83200  1.000 42.41000  ? 154 ASN A N    1 
ATOM   2328 C CA   . ASN A 1 154 ? 16.91300  -38.11700 13.02500  1.000 47.09000  ? 154 ASN A CA   1 
ATOM   2329 C C    . ASN A 1 154 ? 18.33300  -37.71500 13.44700  1.000 55.85000  ? 154 ASN A C    1 
ATOM   2330 O O    . ASN A 1 154 ? 18.59000  -37.45900 14.62800  1.000 64.96000  ? 154 ASN A O    1 
ATOM   2331 C CB   . ASN A 1 154 ? 16.19600  -38.81900 14.17600  1.000 42.62000  ? 154 ASN A CB   1 
ATOM   2332 C CG   . ASN A 1 154 ? 16.94300  -40.06100 14.64800  1.000 57.92000  ? 154 ASN A CG   1 
ATOM   2333 O OD1  . ASN A 1 154 ? 18.14900  -40.21300 14.40400  1.000 67.29000  ? 154 ASN A OD1  1 
ATOM   2334 N ND2  . ASN A 1 154 ? 16.24000  -40.93800 15.35100  1.000 76.82000  ? 154 ASN A ND2  1 
ATOM   2335 H H    . ASN A 1 154 ? 17.24500  -39.74400 11.96100  1.000 50.91000  ? 154 ASN A H    1 
ATOM   2336 H HA   . ASN A 1 154 ? 16.43600  -37.29800 12.81800  1.000 56.53000  ? 154 ASN A HA   1 
ATOM   2337 H HB2  . ASN A 1 154 ? 16.12300  -38.20800 14.92500  1.000 51.17000  ? 154 ASN A HB2  1 
ATOM   2338 H HB3  . ASN A 1 154 ? 15.31300  -39.09100 13.88200  1.000 51.17000  ? 154 ASN A HB3  1 
ATOM   2339 H HD21 . ASN A 1 154 ? 15.40900  -40.78900 15.51700  1.000 92.21000  ? 154 ASN A HD21 1 
ATOM   2340 H HD22 . ASN A 1 154 ? 16.61400  -41.65600 15.64100  1.000 92.21000  ? 154 ASN A HD22 1 
ATOM   2341 N N    . ALA A 1 155 ? 19.26700  -37.66100 12.50000  1.000 44.22000  ? 155 ALA A N    1 
ATOM   2342 C CA   . ALA A 1 155 ? 20.64600  -37.21700 12.71100  1.000 60.89000  ? 155 ALA A CA   1 
ATOM   2343 C C    . ALA A 1 155 ? 21.48000  -38.21700 13.49300  1.000 71.86000  ? 155 ALA A C    1 
ATOM   2344 O O    . ALA A 1 155 ? 22.61000  -37.88600 13.89800  1.000 68.98000  ? 155 ALA A O    1 
ATOM   2345 C CB   . ALA A 1 155 ? 20.73200  -35.87300 13.44500  1.000 59.12000  ? 155 ALA A CB   1 
ATOM   2346 H H    . ALA A 1 155 ? 19.11700  -37.88900 11.68500  1.000 53.09000  ? 155 ALA A H    1 
ATOM   2347 H HA   . ALA A 1 155 ? 21.03100  -37.11300 11.82700  1.000 73.09000  ? 155 ALA A HA   1 
ATOM   2348 H HB1  . ALA A 1 155 ? 20.88300  -36.03800 14.38900  1.000 70.96000  ? 155 ALA A HB1  1 
ATOM   2349 H HB2  . ALA A 1 155 ? 21.46800  -35.35900 13.07700  1.000 70.96000  ? 155 ALA A HB2  1 
ATOM   2350 H HB3  . ALA A 1 155 ? 19.89900  -35.39200 13.32100  1.000 70.96000  ? 155 ALA A HB3  1 
ATOM   2351 N N    . GLY A 1 156 ? 20.95600  -39.41900 13.74300  1.000 67.46000  ? 156 GLY A N    1 
ATOM   2352 C CA   . GLY A 1 156 ? 21.71700  -40.47200 14.38700  1.000 59.30000  ? 156 GLY A CA   1 
ATOM   2353 C C    . GLY A 1 156 ? 22.68200  -41.13700 13.42700  1.000 64.53000  ? 156 GLY A C    1 
ATOM   2354 O O    . GLY A 1 156 ? 23.24800  -40.50400 12.52000  1.000 59.11000  ? 156 GLY A O    1 
ATOM   2355 H H    . GLY A 1 156 ? 20.15000  -39.64500 13.54300  1.000 80.97000  ? 156 GLY A H    1 
ATOM   2356 H HA2  . GLY A 1 156 ? 22.22500  -40.09900 15.12400  1.000 71.17000  ? 156 GLY A HA2  1 
ATOM   2357 H HA3  . GLY A 1 156 ? 21.11000  -41.14700 14.73000  1.000 71.17000  ? 156 GLY A HA3  1 
ATOM   2358 N N    . GLY A 1 157 ? 22.88000  -42.43300 13.62800  1.000 44.67000  ? 157 GLY A N    1 
ATOM   2359 C CA   . GLY A 1 157 ? 23.66500  -43.23500 12.71800  1.000 39.12000  ? 157 GLY A CA   1 
ATOM   2360 C C    . GLY A 1 157 ? 22.86500  -44.09300 11.76300  1.000 44.00000  ? 157 GLY A C    1 
ATOM   2361 O O    . GLY A 1 157 ? 23.47300  -44.81100 10.95000  1.000 36.89000  ? 157 GLY A O    1 
ATOM   2362 H H    . GLY A 1 157 ? 22.56200  -42.87100 14.29700  1.000 53.62000  ? 157 GLY A H    1 
ATOM   2363 H HA2  . GLY A 1 157 ? 24.22200  -42.64400 12.18700  1.000 46.97000  ? 157 GLY A HA2  1 
ATOM   2364 H HA3  . GLY A 1 157 ? 24.23400  -43.82400 13.23700  1.000 46.97000  ? 157 GLY A HA3  1 
ATOM   2365 N N    . LYS A 1 158 ? 21.52500  -44.00000 11.80900  1.000 40.00000  ? 158 LYS A N    1 
ATOM   2366 C CA   . LYS A 1 158 ? 20.64900  -44.79500 10.96000  1.000 31.75000  ? 158 LYS A CA   1 
ATOM   2367 C C    . LYS A 1 158 ? 19.68300  -43.90000 10.19600  1.000 29.99000  ? 158 LYS A C    1 
ATOM   2368 O O    . LYS A 1 158 ? 19.31100  -42.80900 10.65100  1.000 36.26000  ? 158 LYS A O    1 
ATOM   2369 C CB   . LYS A 1 158 ? 19.83100  -45.79600 11.77700  1.000 34.63000  ? 158 LYS A CB   1 
ATOM   2370 H H    . LYS A 1 158 ? 21.10100  -43.47100 12.33800  1.000 48.01000  ? 158 LYS A H    1 
ATOM   2371 H HA   . LYS A 1 158 ? 21.20000  -45.27100 10.31900  1.000 38.12000  ? 158 LYS A HA   1 
ATOM   2372 N N    . PHE A 1 159 ? 19.26300  -44.39600 9.03500   1.000 27.86000  ? 159 PHE A N    1 
ATOM   2373 C CA   . PHE A 1 159 ? 18.16700  -43.77600 8.29200   1.000 26.14000  ? 159 PHE A CA   1 
ATOM   2374 C C    . PHE A 1 159 ? 17.25700  -44.88900 7.80200   1.000 22.30000  ? 159 PHE A C    1 
ATOM   2375 O O    . PHE A 1 159 ? 17.62800  -46.06200 7.74300   1.000 24.73000  ? 159 PHE A O    1 
ATOM   2376 C CB   . PHE A 1 159 ? 18.66300  -42.93500 7.14400   1.000 25.95000  ? 159 PHE A CB   1 
ATOM   2377 C CG   . PHE A 1 159 ? 19.40000  -43.68300 6.05800   1.000 24.81000  ? 159 PHE A CG   1 
ATOM   2378 C CD1  . PHE A 1 159 ? 20.81600  -43.78000 6.09000   1.000 27.94000  ? 159 PHE A CD1  1 
ATOM   2379 C CD2  . PHE A 1 159 ? 18.73800  -44.20400 4.96200   1.000 22.98000  ? 159 PHE A CD2  1 
ATOM   2380 C CE1  . PHE A 1 159 ? 21.48700  -44.37600 5.06600   1.000 24.00000  ? 159 PHE A CE1  1 
ATOM   2381 C CE2  . PHE A 1 159 ? 19.40500  -44.78900 3.91600   1.000 20.80000  ? 159 PHE A CE2  1 
ATOM   2382 C CZ   . PHE A 1 159 ? 20.80800  -44.88400 3.95300   1.000 21.61000  ? 159 PHE A CZ   1 
ATOM   2383 H H    . PHE A 1 159 ? 19.59600  -45.09200 8.65600   1.000 33.45000  ? 159 PHE A H    1 
ATOM   2384 H HA   . PHE A 1 159 ? 17.66300  -43.18700 8.87500   1.000 31.39000  ? 159 PHE A HA   1 
ATOM   2385 H HB2  . PHE A 1 159 ? 17.89900  -42.50400 6.73000   1.000 31.16000  ? 159 PHE A HB2  1 
ATOM   2386 H HB3  . PHE A 1 159 ? 19.27100  -42.26600 7.49700   1.000 31.16000  ? 159 PHE A HB3  1 
ATOM   2387 H HD1  . PHE A 1 159 ? 21.28700  -43.43500 6.81300   1.000 33.55000  ? 159 PHE A HD1  1 
ATOM   2388 H HD2  . PHE A 1 159 ? 17.81000  -44.15600 4.93400   1.000 27.60000  ? 159 PHE A HD2  1 
ATOM   2389 H HE1  . PHE A 1 159 ? 22.41300  -44.44700 5.10700   1.000 28.82000  ? 159 PHE A HE1  1 
ATOM   2390 H HE2  . PHE A 1 159 ? 18.93300  -45.12100 3.18700   1.000 24.98000  ? 159 PHE A HE2  1 
ATOM   2391 H HZ   . PHE A 1 159 ? 21.27500  -45.27800 3.25100   1.000 25.96000  ? 159 PHE A HZ   1 
ATOM   2392 N N    . THR A 1 160 ? 16.05000  -44.53500 7.35500   1.000 25.94000  ? 160 THR A N    1 
ATOM   2393 C CA   A THR A 1 160 ? 15.15600  -45.50400 6.74900   0.860 23.29000  ? 160 THR A CA   1 
ATOM   2394 C CA   B THR A 1 160 ? 15.20500  -45.53500 6.71800   0.140 22.92000  ? 160 THR A CA   1 
ATOM   2395 C C    . THR A 1 160 ? 14.75400  -45.07500 5.33900   1.000 21.23000  ? 160 THR A C    1 
ATOM   2396 O O    . THR A 1 160 ? 14.78500  -43.87900 5.02600   1.000 20.93000  ? 160 THR A O    1 
ATOM   2397 C CB   A THR A 1 160 ? 13.84900  -45.66800 7.52700   0.860 23.79000  ? 160 THR A CB   1 
ATOM   2398 C CB   B THR A 1 160 ? 13.96000  -45.84600 7.54100   0.140 25.17000  ? 160 THR A CB   1 
ATOM   2399 O OG1  A THR A 1 160 ? 13.19500  -44.40400 7.70900   0.860 23.77000  ? 160 THR A OG1  1 
ATOM   2400 O OG1  B THR A 1 160 ? 13.13300  -46.73800 6.79300   0.140 27.88000  ? 160 THR A OG1  1 
ATOM   2401 C CG2  A THR A 1 160 ? 14.12700  -46.24700 8.93800   0.860 26.72000  ? 160 THR A CG2  1 
ATOM   2402 C CG2  B THR A 1 160 ? 13.18800  -44.58300 7.83500   0.140 24.20000  ? 160 THR A CG2  1 
ATOM   2403 H H    A THR A 1 160 ? 15.73200  -43.73700 7.39500   0.860 31.15000  ? 160 THR A H    1 
ATOM   2404 H H    B THR A 1 160 ? 15.71300  -43.74600 7.40900   0.140 31.15000  ? 160 THR A H    1 
ATOM   2405 H HA   A THR A 1 160 ? 15.64100  -46.34400 6.72500   0.860 27.97000  ? 160 THR A HA   1 
ATOM   2406 H HA   B THR A 1 160 ? 15.73500  -46.34100 6.62400   0.140 27.52000  ? 160 THR A HA   1 
ATOM   2407 H HB   A THR A 1 160 ? 13.27600  -46.26700 7.02200   0.860 28.57000  ? 160 THR A HB   1 
ATOM   2408 H HB   B THR A 1 160 ? 14.21300  -46.25000 8.38600   0.140 30.23000  ? 160 THR A HB   1 
ATOM   2409 H HG1  A THR A 1 160 ? 13.15000  -43.99600 6.97700   0.860 28.54000  ? 160 THR A HG1  1 
ATOM   2410 H HG1  B THR A 1 160 ? 13.50800  -47.48600 6.72100   0.140 33.48000  ? 160 THR A HG1  1 
ATOM   2411 H HG21 A THR A 1 160 ? 14.66300  -47.05300 8.86600   0.860 32.08000  ? 160 THR A HG21 1 
ATOM   2412 H HG21 B THR A 1 160 ? 13.29500  -43.95100 7.10700   0.140 29.06000  ? 160 THR A HG21 1 
ATOM   2413 H HG22 A THR A 1 160 ? 14.60700  -45.59700 9.47500   0.860 32.08000  ? 160 THR A HG22 1 
ATOM   2414 H HG22 B THR A 1 160 ? 12.24500  -44.78700 7.93900   0.140 29.06000  ? 160 THR A HG22 1 
ATOM   2415 H HG23 A THR A 1 160 ? 13.29100  -46.46400 9.37800   0.860 32.08000  ? 160 THR A HG23 1 
ATOM   2416 H HG23 B THR A 1 160 ? 13.51400  -44.17800 8.65400   0.140 29.06000  ? 160 THR A HG23 1 
ATOM   2417 N N    . VAL A 1 161 ? 14.35300  -46.05900 4.50700   1.000 19.17000  ? 161 VAL A N    1 
ATOM   2418 C CA   . VAL A 1 161 ? 13.80900  -45.81600 3.17900   1.000 19.05000  ? 161 VAL A CA   1 
ATOM   2419 C C    . VAL A 1 161 ? 12.55500  -46.66200 3.10200   1.000 23.94000  ? 161 VAL A C    1 
ATOM   2420 O O    . VAL A 1 161 ? 12.61200  -47.85800 3.40800   1.000 25.55000  ? 161 VAL A O    1 
ATOM   2421 C CB   . VAL A 1 161 ? 14.76100  -46.11200 2.00900   1.000 19.25000  ? 161 VAL A CB   1 
ATOM   2422 C CG1  . VAL A 1 161 ? 14.15600  -45.81100 0.67100   1.000 25.15000  ? 161 VAL A CG1  1 
ATOM   2423 C CG2  . VAL A 1 161 ? 16.04100  -45.24500 2.18500   1.000 25.18000  ? 161 VAL A CG2  1 
ATOM   2424 H H    . VAL A 1 161 ? 14.39300  -46.89400 4.70800   1.000 23.02000  ? 161 VAL A H    1 
ATOM   2425 H HA   . VAL A 1 161 ? 13.60500  -44.87300 3.08400   1.000 22.88000  ? 161 VAL A HA   1 
ATOM   2426 H HB   . VAL A 1 161 ? 14.96500  -47.06000 2.02100   1.000 23.12000  ? 161 VAL A HB   1 
ATOM   2427 H HG11 . VAL A 1 161 ? 13.65900  -44.98000 0.72800   1.000 30.20000  ? 161 VAL A HG11 1 
ATOM   2428 H HG12 . VAL A 1 161 ? 14.86600  -45.72800 0.01500   1.000 30.20000  ? 161 VAL A HG12 1 
ATOM   2429 H HG13 . VAL A 1 161 ? 13.56100  -46.53600 0.42300   1.000 30.20000  ? 161 VAL A HG13 1 
ATOM   2430 H HG21 . VAL A 1 161 ? 15.77900  -44.34000 2.41500   1.000 30.23000  ? 161 VAL A HG21 1 
ATOM   2431 H HG22 . VAL A 1 161 ? 16.58200  -45.62400 2.89600   1.000 30.23000  ? 161 VAL A HG22 1 
ATOM   2432 H HG23 . VAL A 1 161 ? 16.53900  -45.24500 1.35300   1.000 30.23000  ? 161 VAL A HG23 1 
ATOM   2433 N N    . THR A 1 162 ? 11.44000  -46.04700 2.72100   1.000 17.58000  ? 162 THR A N    1 
ATOM   2434 C CA   . THR A 1 162 ? 10.10600  -46.66000 2.69000   1.000 19.08000  ? 162 THR A CA   1 
ATOM   2435 C C    . THR A 1 162 ? 9.37100   -46.23500 1.43900   1.000 18.53000  ? 162 THR A C    1 
ATOM   2436 O O    . THR A 1 162 ? 9.37100   -45.04900 1.09100   1.000 17.74000  ? 162 THR A O    1 
ATOM   2437 C CB   . THR A 1 162 ? 9.29300   -46.23800 3.90200   1.000 17.97000  ? 162 THR A CB   1 
ATOM   2438 O OG1  . THR A 1 162 ? 10.02700  -46.39200 5.16200   1.000 23.90000  ? 162 THR A OG1  1 
ATOM   2439 C CG2  . THR A 1 162 ? 8.04100   -47.11400 4.01900   1.000 24.56000  ? 162 THR A CG2  1 
ATOM   2440 H H    . THR A 1 162 ? 11.42500  -45.22800 2.45900   1.000 21.12000  ? 162 THR A H    1 
ATOM   2441 H HA   . THR A 1 162 ? 10.20600  -47.62400 2.67800   1.000 22.92000  ? 162 THR A HA   1 
ATOM   2442 H HB   . THR A 1 162 ? 9.07000   -45.30200 3.77800   1.000 21.58000  ? 162 THR A HB   1 
ATOM   2443 H HG1  . THR A 1 162 ? 10.67200  -45.85400 5.18600   1.000 28.70000  ? 162 THR A HG1  1 
ATOM   2444 H HG21 . THR A 1 162 ? 7.52100   -46.84800 4.79400   1.000 29.49000  ? 162 THR A HG21 1 
ATOM   2445 H HG22 . THR A 1 162 ? 7.49300   -47.01700 3.22400   1.000 29.49000  ? 162 THR A HG22 1 
ATOM   2446 H HG23 . THR A 1 162 ? 8.29500   -48.04500 4.11500   1.000 29.49000  ? 162 THR A HG23 1 
ATOM   2447 N N    . LEU A 1 163 ? 8.72000   -47.17200 0.75300   1.000 18.01000  ? 163 LEU A N    1 
ATOM   2448 C CA   . LEU A 1 163 ? 7.82200   -46.84100 -0.34200  1.000 18.32000  ? 163 LEU A CA   1 
ATOM   2449 C C    . LEU A 1 163 ? 6.79300   -45.86000 0.19300   1.000 16.42000  ? 163 LEU A C    1 
ATOM   2450 O O    . LEU A 1 163 ? 6.23900   -46.10200 1.27500   1.000 17.82000  ? 163 LEU A O    1 
ATOM   2451 C CB   . LEU A 1 163 ? 7.10600   -48.13400 -0.85400  1.000 19.60000  ? 163 LEU A CB   1 
ATOM   2452 C CG   . LEU A 1 163 ? 6.22900   -47.95100 -2.02700  1.000 20.98000  ? 163 LEU A CG   1 
ATOM   2453 C CD1  . LEU A 1 163 ? 6.90300   -47.64500 -3.32000  1.000 19.80000  ? 163 LEU A CD1  1 
ATOM   2454 C CD2  . LEU A 1 163 ? 5.35400   -49.22700 -2.19100  1.000 27.43000  ? 163 LEU A CD2  1 
ATOM   2455 H H    . LEU A 1 163 ? 8.78400   -48.01600 0.90600   1.000 21.63000  ? 163 LEU A H    1 
ATOM   2456 H HA   . LEU A 1 163 ? 8.30600   -46.45800 -1.09100  1.000 22.01000  ? 163 LEU A HA   1 
ATOM   2457 H HB2  . LEU A 1 163 ? 7.78500   -48.78200 -1.09800  1.000 23.54000  ? 163 LEU A HB2  1 
ATOM   2458 H HB3  . LEU A 1 163 ? 6.55700   -48.48300 -0.13400  1.000 23.54000  ? 163 LEU A HB3  1 
ATOM   2459 H HG   . LEU A 1 163 ? 5.70400   -47.15600 -1.84400  1.000 25.20000  ? 163 LEU A HG   1 
ATOM   2460 H HD11 . LEU A 1 163 ? 6.25500   -47.71600 -4.03800  1.000 23.78000  ? 163 LEU A HD11 1 
ATOM   2461 H HD12 . LEU A 1 163 ? 7.26100   -46.74400 -3.28400  1.000 23.78000  ? 163 LEU A HD12 1 
ATOM   2462 H HD13 . LEU A 1 163 ? 7.62200   -48.28100 -3.45900  1.000 23.78000  ? 163 LEU A HD13 1 
ATOM   2463 H HD21 . LEU A 1 163 ? 4.81500   -49.13900 -2.99300  1.000 32.93000  ? 163 LEU A HD21 1 
ATOM   2464 H HD22 . LEU A 1 163 ? 5.93400   -50.00100 -2.26500  1.000 32.93000  ? 163 LEU A HD22 1 
ATOM   2465 H HD23 . LEU A 1 163 ? 4.77900   -49.31700 -1.41400  1.000 32.93000  ? 163 LEU A HD23 1 
ATOM   2466 N N    . ASP A 1 164 ? 6.54800   -44.75700 -0.54800  1.000 16.04000  ? 164 ASP A N    1 
ATOM   2467 C CA   . ASP A 1 164 ? 5.69000   -43.65400 -0.07400  1.000 18.64000  ? 164 ASP A CA   1 
ATOM   2468 C C    . ASP A 1 164 ? 4.23500   -43.94700 -0.38400  1.000 15.27000  ? 164 ASP A C    1 
ATOM   2469 O O    . ASP A 1 164 ? 3.79000   -43.82600 -1.51800  1.000 17.17000  ? 164 ASP A O    1 
ATOM   2470 C CB   . ASP A 1 164 ? 6.15800   -42.34000 -0.69800  1.000 15.17000  ? 164 ASP A CB   1 
ATOM   2471 C CG   . ASP A 1 164 ? 5.48400   -41.14400 -0.10000  1.000 17.49000  ? 164 ASP A CG   1 
ATOM   2472 O OD1  . ASP A 1 164 ? 4.36800   -41.36500 0.42800   1.000 18.45000  ? 164 ASP A OD1  1 
ATOM   2473 O OD2  . ASP A 1 164 ? 5.97500   -40.03900 -0.29300  1.000 16.46000  ? 164 ASP A OD2  1 
ATOM   2474 H H    . ASP A 1 164 ? 6.87200   -44.62600 -1.33300  1.000 19.27000  ? 164 ASP A H    1 
ATOM   2475 H HA   . ASP A 1 164 ? 5.75800   -43.58300 0.89100   1.000 22.39000  ? 164 ASP A HA   1 
ATOM   2476 H HB2  . ASP A 1 164 ? 7.11400   -42.24700 -0.55900  1.000 18.22000  ? 164 ASP A HB2  1 
ATOM   2477 H HB3  . ASP A 1 164 ? 5.96100   -42.35300 -1.64800  1.000 18.22000  ? 164 ASP A HB3  1 
ATOM   2478 N N    . GLU A 1 165 ? 3.48800   -44.27100 0.67700   1.000 18.77000  ? 165 GLU A N    1 
ATOM   2479 C CA   . GLU A 1 165 ? 2.02300   -44.46900 0.60400   1.000 19.59000  ? 165 GLU A CA   1 
ATOM   2480 C C    . GLU A 1 165 ? 1.28400   -43.46500 1.47100   1.000 22.77000  ? 165 GLU A C    1 
ATOM   2481 O O    . GLU A 1 165 ? 0.09700   -43.69000 1.82900   1.000 21.89000  ? 165 GLU A O    1 
ATOM   2482 C CB   . GLU A 1 165 ? 1.68000   -45.90200 1.01700   1.000 23.42000  ? 165 GLU A CB   1 
ATOM   2483 C CG   . GLU A 1 165 ? 2.52900   -46.93600 0.34100   1.000 25.85000  ? 165 GLU A CG   1 
ATOM   2484 C CD   . GLU A 1 165 ? 2.18000   -48.40500 0.69000   1.000 29.71000  ? 165 GLU A CD   1 
ATOM   2485 O OE1  . GLU A 1 165 ? 2.24400   -48.76000 1.88100   1.000 34.56000  ? 165 GLU A OE1  1 
ATOM   2486 O OE2  . GLU A 1 165 ? 1.99100   -49.15800 -0.27200  1.000 37.90000  ? 165 GLU A OE2  1 
ATOM   2487 H H    . GLU A 1 165 ? 3.80700   -44.38500 1.46700   1.000 22.54000  ? 165 GLU A H    1 
ATOM   2488 H HA   . GLU A 1 165 ? 1.72000   -44.34000 -0.30800  1.000 23.52000  ? 165 GLU A HA   1 
ATOM   2489 H HB2  . GLU A 1 165 ? 1.80700   -45.99200 1.97400   1.000 28.12000  ? 165 GLU A HB2  1 
ATOM   2490 H HB3  . GLU A 1 165 ? 0.75400   -46.08100 0.78700   1.000 28.12000  ? 165 GLU A HB3  1 
ATOM   2491 H HG2  . GLU A 1 165 ? 2.43000   -46.83500 -0.61900  1.000 31.04000  ? 165 GLU A HG2  1 
ATOM   2492 H HG3  . GLU A 1 165 ? 3.45300   -46.78900 0.59600   1.000 31.04000  ? 165 GLU A HG3  1 
ATOM   2493 N N    . THR A 1 166 ? 1.95200   -42.35500 1.84800   1.000 16.94000  ? 166 THR A N    1 
ATOM   2494 C CA   . THR A 1 166 ? 1.34100   -41.39600 2.75500   1.000 18.50000  ? 166 THR A CA   1 
ATOM   2495 C C    . THR A 1 166 ? 1.47700   -39.93800 2.35800   1.000 17.32000  ? 166 THR A C    1 
ATOM   2496 O O    . THR A 1 166 ? 0.81600   -39.10200 2.98900   1.000 18.44000  ? 166 THR A O    1 
ATOM   2497 C CB   . THR A 1 166 ? 1.89100   -41.55500 4.16200   1.000 20.83000  ? 166 THR A CB   1 
ATOM   2498 O OG1  . THR A 1 166 ? 3.29900   -41.27200 4.16600   1.000 21.08000  ? 166 THR A OG1  1 
ATOM   2499 C CG2  . THR A 1 166 ? 1.63000   -42.95800 4.65300   1.000 23.33000  ? 166 THR A CG2  1 
ATOM   2500 H H    . THR A 1 166 ? 2.74700   -42.15000 1.59000   1.000 20.35000  ? 166 THR A H    1 
ATOM   2501 H HA   . THR A 1 166 ? 0.39100   -41.59500 2.77100   1.000 22.22000  ? 166 THR A HA   1 
ATOM   2502 H HB   . THR A 1 166 ? 1.45500   -40.93700 4.76900   1.000 25.02000  ? 166 THR A HB   1 
ATOM   2503 H HG1  . THR A 1 166 ? 3.64900   -41.56500 4.87000   1.000 25.31000  ? 166 THR A HG1  1 
ATOM   2504 H HG21 . THR A 1 166 ? 1.80400   -43.01300 5.60500   1.000 28.02000  ? 166 THR A HG21 1 
ATOM   2505 H HG22 . THR A 1 166 ? 0.70600   -43.20100 4.48700   1.000 28.02000  ? 166 THR A HG22 1 
ATOM   2506 H HG23 . THR A 1 166 ? 2.20800   -43.58400 4.19000   1.000 28.02000  ? 166 THR A HG23 1 
ATOM   2507 N N    . ASN A 1 167 ? 2.33600   -39.55900 1.40500   1.000 16.77000  ? 167 ASN A N    1 
ATOM   2508 C CA   . ASN A 1 167 ? 2.46000   -38.16100 1.04600   1.000 16.08000  ? 167 ASN A CA   1 
ATOM   2509 C C    . ASN A 1 167 ? 1.80600   -37.85500 -0.29400  1.000 15.60000  ? 167 ASN A C    1 
ATOM   2510 O O    . ASN A 1 167 ? 1.53300   -38.73600 -1.13800  1.000 17.31000  ? 167 ASN A O    1 
ATOM   2511 C CB   . ASN A 1 167 ? 3.94100   -37.77400 0.99100   1.000 16.77000  ? 167 ASN A CB   1 
ATOM   2512 C CG   . ASN A 1 167 ? 4.61200   -37.91300 2.28400   1.000 18.41000  ? 167 ASN A CG   1 
ATOM   2513 O OD1  . ASN A 1 167 ? 4.21400   -37.25100 3.26800   1.000 20.18000  ? 167 ASN A OD1  1 
ATOM   2514 N ND2  . ASN A 1 167 ? 5.58700   -38.85800 2.40900   1.000 17.20000  ? 167 ASN A ND2  1 
ATOM   2515 H H    . ASN A 1 167 ? 2.84600   -40.09300 0.96500   1.000 20.14000  ? 167 ASN A H    1 
ATOM   2516 H HA   . ASN A 1 167 ? 2.00000   -37.63300 1.71700   1.000 19.32000  ? 167 ASN A HA   1 
ATOM   2517 H HB2  . ASN A 1 167 ? 4.39500   -38.34900 0.35500   1.000 20.14000  ? 167 ASN A HB2  1 
ATOM   2518 H HB3  . ASN A 1 167 ? 4.01600   -36.84800 0.71300   1.000 20.14000  ? 167 ASN A HB3  1 
ATOM   2519 H HD21 . ASN A 1 167 ? 5.99500   -38.95900 3.15900   1.000 20.66000  ? 167 ASN A HD21 1 
ATOM   2520 H HD22 . ASN A 1 167 ? 5.79300   -39.35400 1.73800   1.000 20.66000  ? 167 ASN A HD22 1 
ATOM   2521 N N    . GLU A 1 168 ? 1.64700   -36.55800 -0.53600  1.000 15.94000  ? 168 GLU A N    1 
ATOM   2522 C CA   . GLU A 1 168 ? 1.15400   -36.10900 -1.85400  1.000 15.25000  ? 168 GLU A CA   1 
ATOM   2523 C C    . GLU A 1 168 ? 2.09400   -36.59400 -2.96100  1.000 16.12000  ? 168 GLU A C    1 
ATOM   2524 O O    . GLU A 1 168 ? 3.31300   -36.69100 -2.76600  1.000 16.58000  ? 168 GLU A O    1 
ATOM   2525 C CB   . GLU A 1 168 ? 1.05000   -34.58400 -1.88300  1.000 17.10000  ? 168 GLU A CB   1 
ATOM   2526 C CG   . GLU A 1 168 ? 0.51500   -34.02200 -3.23600  1.000 23.48000  ? 168 GLU A CG   1 
ATOM   2527 C CD   . GLU A 1 168 ? 0.46900   -32.46100 -3.30200  1.000 38.33000  ? 168 GLU A CD   1 
ATOM   2528 O OE1  . GLU A 1 168 ? 0.95400   -31.76200 -2.38400  1.000 33.76000  ? 168 GLU A OE1  1 
ATOM   2529 O OE2  . GLU A 1 168 ? -0.08400  -31.94300 -4.29100  1.000 35.28000  ? 168 GLU A OE2  1 
ATOM   2530 H H    . GLU A 1 168 ? 1.81000   -35.92700 0.02500   1.000 19.15000  ? 168 GLU A H    1 
ATOM   2531 H HA   . GLU A 1 168 ? 0.27100   -36.47600 -2.01600  1.000 18.31000  ? 168 GLU A HA   1 
ATOM   2532 H HB2  . GLU A 1 168 ? 0.44300   -34.29900 -1.18200  1.000 20.54000  ? 168 GLU A HB2  1 
ATOM   2533 H HB3  . GLU A 1 168 ? 1.93100   -34.20800 -1.73300  1.000 20.54000  ? 168 GLU A HB3  1 
ATOM   2534 H HG2  . GLU A 1 168 ? 1.09300   -34.33000 -3.95100  1.000 28.20000  ? 168 GLU A HG2  1 
ATOM   2535 H HG3  . GLU A 1 168 ? -0.38800  -34.34900 -3.37400  1.000 28.20000  ? 168 GLU A HG3  1 
ATOM   2536 N N    . ARG A 1 169 ? 1.55400   -36.95500 -4.10200  1.000 16.59000  ? 169 ARG A N    1 
ATOM   2537 C CA   . ARG A 1 169 ? 2.38300   -37.36500 -5.22300  1.000 16.14000  ? 169 ARG A CA   1 
ATOM   2538 C C    . ARG A 1 169 ? 3.15100   -36.17600 -5.74700  1.000 16.22000  ? 169 ARG A C    1 
ATOM   2539 O O    . ARG A 1 169 ? 2.57900   -35.12100 -6.03700  1.000 17.89000  ? 169 ARG A O    1 
ATOM   2540 C CB   . ARG A 1 169 ? 1.55300   -37.95200 -6.37500  1.000 16.12000  ? 169 ARG A CB   1 
ATOM   2541 C CG   . ARG A 1 169 ? 0.75100   -39.17500 -6.00400  1.000 16.83000  ? 169 ARG A CG   1 
ATOM   2542 C CD   . ARG A 1 169 ? 1.57300   -40.30400 -5.56000  1.000 19.39000  ? 169 ARG A CD   1 
ATOM   2543 N NE   . ARG A 1 169 ? 1.75500   -40.29400 -4.11300  1.000 15.40000  ? 169 ARG A NE   1 
ATOM   2544 C CZ   . ARG A 1 169 ? 2.42000   -41.22200 -3.43900  1.000 16.18000  ? 169 ARG A CZ   1 
ATOM   2545 N NH1  . ARG A 1 169 ? 3.00200   -42.22300 -4.08300  1.000 20.25000  ? 169 ARG A NH1  1 
ATOM   2546 N NH2  . ARG A 1 169 ? 2.47600   -41.16600 -2.12300  1.000 17.55000  ? 169 ARG A NH2  1 
ATOM   2547 H H    . ARG A 1 169 ? 0.70900   -36.97300 -4.25900  1.000 19.92000  ? 169 ARG A H    1 
ATOM   2548 H HA   . ARG A 1 169 ? 2.98900   -38.05400 -4.90900  1.000 19.39000  ? 169 ARG A HA   1 
ATOM   2549 H HB2  . ARG A 1 169 ? 0.93100   -37.27600 -6.68400  1.000 19.36000  ? 169 ARG A HB2  1 
ATOM   2550 H HB3  . ARG A 1 169 ? 2.15500   -38.20300 -7.09300  1.000 19.36000  ? 169 ARG A HB3  1 
ATOM   2551 H HG2  . ARG A 1 169 ? 0.14800   -38.94600 -5.28000  1.000 20.21000  ? 169 ARG A HG2  1 
ATOM   2552 H HG3  . ARG A 1 169 ? 0.24500   -39.46500 -6.77900  1.000 20.21000  ? 169 ARG A HG3  1 
ATOM   2553 H HD2  . ARG A 1 169 ? 1.13900   -41.13500 -5.80800  1.000 23.29000  ? 169 ARG A HD2  1 
ATOM   2554 H HD3  . ARG A 1 169 ? 2.44700   -40.24900 -5.97800  1.000 23.29000  ? 169 ARG A HD3  1 
ATOM   2555 H HE   . ARG A 1 169 ? 1.40800   -39.64400 -3.66800  1.000 18.50000  ? 169 ARG A HE   1 
ATOM   2556 H HH11 . ARG A 1 169 ? 2.94800   -42.27200 -4.94000  1.000 24.32000  ? 169 ARG A HH11 1 
ATOM   2557 H HH12 . ARG A 1 169 ? 3.43200   -42.82400 -3.64400  1.000 24.32000  ? 169 ARG A HH12 1 
ATOM   2558 H HH21 . ARG A 1 169 ? 2.08100   -40.52800 -1.70200  1.000 21.08000  ? 169 ARG A HH21 1 
ATOM   2559 H HH22 . ARG A 1 169 ? 2.90700   -41.76800 -1.68500  1.000 21.08000  ? 169 ARG A HH22 1 
ATOM   2560 N N    . LEU A 1 170 ? 4.46000   -36.37100 -5.96300  1.000 16.28000  ? 170 LEU A N    1 
ATOM   2561 C CA   . LEU A 1 170 ? 5.27200   -35.29400 -6.51300  1.000 15.59000  ? 170 LEU A CA   1 
ATOM   2562 C C    . LEU A 1 170 ? 5.23100   -35.19500 -8.01200  1.000 16.73000  ? 170 LEU A C    1 
ATOM   2563 O O    . LEU A 1 170 ? 5.54600   -34.10700 -8.56600  1.000 17.21000  ? 170 LEU A O    1 
ATOM   2564 C CB   . LEU A 1 170 ? 6.74300   -35.54000 -6.08700  1.000 15.56000  ? 170 LEU A CB   1 
ATOM   2565 C CG   . LEU A 1 170 ? 7.02400   -35.47500 -4.58700  1.000 15.94000  ? 170 LEU A CG   1 
ATOM   2566 C CD1  . LEU A 1 170 ? 8.52900   -35.69000 -4.32900  1.000 20.27000  ? 170 LEU A CD1  1 
ATOM   2567 C CD2  . LEU A 1 170 ? 6.54000   -34.16200 -3.97100  1.000 19.94000  ? 170 LEU A CD2  1 
ATOM   2568 H H    . LEU A 1 170 ? 4.88400   -37.10100 -5.80000  1.000 19.55000  ? 170 LEU A H    1 
ATOM   2569 H HA   . LEU A 1 170 ? 4.94400   -34.45200 -6.16300  1.000 18.73000  ? 170 LEU A HA   1 
ATOM   2570 H HB2  . LEU A 1 170 ? 7.00200   -36.42500 -6.39000  1.000 18.69000  ? 170 LEU A HB2  1 
ATOM   2571 H HB3  . LEU A 1 170 ? 7.29800   -34.86800 -6.51300  1.000 18.69000  ? 170 LEU A HB3  1 
ATOM   2572 H HG   . LEU A 1 170 ? 6.52800   -36.18300 -4.14500  1.000 19.14000  ? 170 LEU A HG   1 
ATOM   2573 H HD11 . LEU A 1 170 ? 8.72500   -35.47600 -3.40400  1.000 24.35000  ? 170 LEU A HD11 1 
ATOM   2574 H HD12 . LEU A 1 170 ? 8.75100   -36.61600 -4.51000  1.000 24.35000  ? 170 LEU A HD12 1 
ATOM   2575 H HD13 . LEU A 1 170 ? 9.03600   -35.10800 -4.91700  1.000 24.35000  ? 170 LEU A HD13 1 
ATOM   2576 H HD21 . LEU A 1 170 ? 6.99600   -34.02300 -3.12600  1.000 23.94000  ? 170 LEU A HD21 1 
ATOM   2577 H HD22 . LEU A 1 170 ? 6.74100   -33.43500 -4.58000  1.000 23.94000  ? 170 LEU A HD22 1 
ATOM   2578 H HD23 . LEU A 1 170 ? 5.58200   -34.21600 -3.82400  1.000 23.94000  ? 170 LEU A HD23 1 
ATOM   2579 N N    . GLY A 1 171 ? 4.87200   -36.28800 -8.68900  1.000 17.17000  ? 171 GLY A N    1 
ATOM   2580 C CA   . GLY A 1 171 ? 4.92900   -36.26200 -10.15500 1.000 17.44000  ? 171 GLY A CA   1 
ATOM   2581 C C    . GLY A 1 171 ? 6.32500   -36.59900 -10.64200 1.000 16.05000  ? 171 GLY A C    1 
ATOM   2582 O O    . GLY A 1 171 ? 6.61800   -37.66100 -11.20800 1.000 17.58000  ? 171 GLY A O    1 
ATOM   2583 H H    . GLY A 1 171 ? 4.60300   -37.02600 -8.33900  1.000 20.63000  ? 171 GLY A H    1 
ATOM   2584 H HA2  . GLY A 1 171 ? 4.30500   -36.91000 -10.51900 1.000 20.94000  ? 171 GLY A HA2  1 
ATOM   2585 H HA3  . GLY A 1 171 ? 4.69000   -35.37800 -10.47600 1.000 20.94000  ? 171 GLY A HA3  1 
ATOM   2586 N N    . ARG A 1 172 ? 7.23800   -35.69700 -10.26400 1.000 15.00000  ? 172 ARG A N    1 
ATOM   2587 C CA   . ARG A 1 172 ? 8.67000   -35.87800 -10.42800 1.000 15.82000  ? 172 ARG A CA   1 
ATOM   2588 C C    . ARG A 1 172 ? 9.33100   -34.85400 -9.51900  1.000 14.15000  ? 172 ARG A C    1 
ATOM   2589 O O    . ARG A 1 172 ? 8.90700   -33.71600 -9.47800  1.000 15.70000  ? 172 ARG A O    1 
ATOM   2590 C CB   . ARG A 1 172 ? 9.13900   -35.68100 -11.87500 1.000 15.95000  ? 172 ARG A CB   1 
ATOM   2591 C CG   . ARG A 1 172 ? 10.59100  -36.03600 -12.07800 1.000 16.44000  ? 172 ARG A CG   1 
ATOM   2592 C CD   . ARG A 1 172 ? 11.15700  -35.37400 -13.37000 1.000 14.91000  ? 172 ARG A CD   1 
ATOM   2593 N NE   . ARG A 1 172 ? 10.98200  -33.94600 -13.41700 1.000 15.03000  ? 172 ARG A NE   1 
ATOM   2594 C CZ   . ARG A 1 172 ? 10.11000  -33.25700 -14.12100 1.000 16.98000  ? 172 ARG A CZ   1 
ATOM   2595 N NH1  . ARG A 1 172 ? 9.27400   -33.85400 -14.99500 1.000 19.12000  ? 172 ARG A NH1  1 
ATOM   2596 N NH2  . ARG A 1 172 ? 10.08000  -31.93500 -13.99300 1.000 16.72000  ? 172 ARG A NH2  1 
ATOM   2597 H H    . ARG A 1 172 ? 7.03900   -34.94500 -9.89700  1.000 18.02000  ? 172 ARG A H    1 
ATOM   2598 H HA   . ARG A 1 172 ? 8.92400   -36.78100 -10.17800 1.000 19.01000  ? 172 ARG A HA   1 
ATOM   2599 H HB2  . ARG A 1 172 ? 8.60800   -36.24700 -12.45700 1.000 19.16000  ? 172 ARG A HB2  1 
ATOM   2600 H HB3  . ARG A 1 172 ? 9.02100   -34.75000 -12.12000 1.000 19.16000  ? 172 ARG A HB3  1 
ATOM   2601 H HG2  . ARG A 1 172 ? 11.10900  -35.72000 -11.32000 1.000 19.75000  ? 172 ARG A HG2  1 
ATOM   2602 H HG3  . ARG A 1 172 ? 10.67900  -36.99800 -12.16300 1.000 19.75000  ? 172 ARG A HG3  1 
ATOM   2603 H HD2  . ARG A 1 172 ? 12.10900  -35.55700 -13.42300 1.000 17.91000  ? 172 ARG A HD2  1 
ATOM   2604 H HD3  . ARG A 1 172 ? 10.70400  -35.75300 -14.13900 1.000 17.91000  ? 172 ARG A HD3  1 
ATOM   2605 H HE   . ARG A 1 172 ? 11.51500  -33.48600 -12.92400 1.000 18.05000  ? 172 ARG A HE   1 
ATOM   2606 H HH11 . ARG A 1 172 ? 9.30400   -34.70700 -15.10400 1.000 22.96000  ? 172 ARG A HH11 1 
ATOM   2607 H HH12 . ARG A 1 172 ? 8.71200   -33.38200 -15.44300 1.000 22.96000  ? 172 ARG A HH12 1 
ATOM   2608 H HH21 . ARG A 1 172 ? 10.62600  -31.54300 -13.45700 1.000 20.08000  ? 172 ARG A HH21 1 
ATOM   2609 H HH22 . ARG A 1 172 ? 9.51500   -31.47200 -14.44600 1.000 20.08000  ? 172 ARG A HH22 1 
ATOM   2610 N N    . GLY A 1 173 ? 10.40300  -35.25500 -8.87200  1.000 13.43000  ? 173 GLY A N    1 
ATOM   2611 C CA   . GLY A 1 173 ? 11.20700  -34.33600 -8.10500  1.000 14.20000  ? 173 GLY A CA   1 
ATOM   2612 C C    . GLY A 1 173 ? 11.44100  -34.75900 -6.67000  1.000 12.88000  ? 173 GLY A C    1 
ATOM   2613 O O    . GLY A 1 173 ? 11.41200  -35.94500 -6.34100  1.000 14.96000  ? 173 GLY A O    1 
ATOM   2614 H H    . GLY A 1 173 ? 10.68900  -36.06600 -8.86100  1.000 16.14000  ? 173 GLY A H    1 
ATOM   2615 H HA2  . GLY A 1 173 ? 12.07300  -34.24400 -8.53300  1.000 17.06000  ? 173 GLY A HA2  1 
ATOM   2616 H HA3  . GLY A 1 173 ? 10.76800  -33.47100 -8.09200  1.000 17.06000  ? 173 GLY A HA3  1 
ATOM   2617 N N    . THR A 1 174 ? 11.67600  -33.77900 -5.76900  1.000 12.04000  ? 174 THR A N    1 
ATOM   2618 C CA   . THR A 1 174 ? 12.09400  -34.06800 -4.39400  1.000 11.60000  ? 174 THR A CA   1 
ATOM   2619 C C    . THR A 1 174 ? 11.45700  -33.04400 -3.48600  1.000 12.51000  ? 174 THR A C    1 
ATOM   2620 O O    . THR A 1 174 ? 11.37800  -31.86000 -3.83000  1.000 14.62000  ? 174 THR A O    1 
ATOM   2621 C CB   . THR A 1 174 ? 13.66900  -34.00400 -4.27400  1.000 14.36000  ? 174 THR A CB   1 
ATOM   2622 O OG1  . THR A 1 174 ? 14.19000  -34.99900 -5.17900  1.000 13.51000  ? 174 THR A OG1  1 
ATOM   2623 C CG2  . THR A 1 174 ? 14.12800  -34.31900 -2.92400  1.000 14.33000  ? 174 THR A CG2  1 
ATOM   2624 H H    . THR A 1 174 ? 11.59700  -32.93900 -5.93900  1.000 14.47000  ? 174 THR A H    1 
ATOM   2625 H HA   . THR A 1 174 ? 11.80200  -34.95000 -4.11600  1.000 13.94000  ? 174 THR A HA   1 
ATOM   2626 H HB   . THR A 1 174 ? 13.98700  -33.11100 -4.48100  1.000 17.25000  ? 174 THR A HB   1 
ATOM   2627 H HG1  . THR A 1 174 ? 14.23500  -35.74300 -4.79200  1.000 16.23000  ? 174 THR A HG1  1 
ATOM   2628 H HG21 . THR A 1 174 ? 15.08600  -34.46700 -2.92500  1.000 17.21000  ? 174 THR A HG21 1 
ATOM   2629 H HG22 . THR A 1 174 ? 13.92300  -33.58400 -2.32400  1.000 17.21000  ? 174 THR A HG22 1 
ATOM   2630 H HG23 . THR A 1 174 ? 13.68600  -35.12000 -2.60200  1.000 17.21000  ? 174 THR A HG23 1 
ATOM   2631 N N    . MET A 1 175 ? 11.03400  -33.48900 -2.31100  1.000 12.10000  ? 175 MET A N    1 
ATOM   2632 C CA   . MET A 1 175 ? 10.54100  -32.54600 -1.28500  1.000 12.75000  ? 175 MET A CA   1 
ATOM   2633 C C    . MET A 1 175 ? 11.23300  -32.86900 0.03000   1.000 13.71000  ? 175 MET A C    1 
ATOM   2634 O O    . MET A 1 175 ? 11.12900  -33.95900 0.46600   1.000 13.47000  ? 175 MET A O    1 
ATOM   2635 C CB   . MET A 1 175 ? 9.03000   -32.59200 -1.05500  1.000 15.14000  ? 175 MET A CB   1 
ATOM   2636 C CG   . MET A 1 175 ? 8.55900   -31.43600 -0.18700  1.000 14.74000  ? 175 MET A CG   1 
ATOM   2637 S SD   . MET A 1 175 ? 6.75600   -31.24500 -0.12700  1.000 23.77000  ? 175 MET A SD   1 
ATOM   2638 C CE   . MET A 1 175 ? 6.36300   -32.60700 0.96000   1.000 17.60000  ? 175 MET A CE   1 
ATOM   2639 H H    . MET A 1 175 ? 11.01600  -34.48400 -2.03400  1.000 14.54000  ? 175 MET A H    1 
ATOM   2640 H HA   . MET A 1 175 ? 10.82300  -31.53900 -1.58200  1.000 15.32000  ? 175 MET A HA   1 
ATOM   2641 H HB2  . MET A 1 175 ? 8.52400   -32.55000 -2.01800  1.000 18.19000  ? 175 MET A HB2  1 
ATOM   2642 H HB3  . MET A 1 175 ? 8.77100   -33.53400 -0.57500  1.000 18.19000  ? 175 MET A HB3  1 
ATOM   2643 H HG2  . MET A 1 175 ? 8.92700   -31.58300 0.82700   1.000 17.71000  ? 175 MET A HG2  1 
ATOM   2644 H HG3  . MET A 1 175 ? 8.99500   -30.51300 -0.56600  1.000 17.71000  ? 175 MET A HG3  1 
ATOM   2645 H HE1  . MET A 1 175 ? 5.28800   -32.63400 1.13500   1.000 21.14000  ? 175 MET A HE1  1 
ATOM   2646 H HE2  . MET A 1 175 ? 6.68000   -33.54100 0.49800   1.000 21.14000  ? 175 MET A HE2  1 
ATOM   2647 H HE3  . MET A 1 175 ? 6.88300   -32.47400 1.90700   1.000 21.14000  ? 175 MET A HE3  1 
ATOM   2648 N N    . LEU A 1 176 ? 11.92700  -31.89300 0.59700   1.000 12.76000  ? 176 LEU A N    1 
ATOM   2649 C CA   . LEU A 1 176 ? 12.53600  -32.05000 1.93000   1.000 13.49000  ? 176 LEU A CA   1 
ATOM   2650 C C    . LEU A 1 176 ? 11.54100  -31.54300 2.96900   1.000 14.99000  ? 176 LEU A C    1 
ATOM   2651 O O    . LEU A 1 176 ? 11.00900  -30.48500 2.76400   1.000 15.84000  ? 176 LEU A O    1 
ATOM   2652 C CB   . LEU A 1 176 ? 13.83200  -31.24000 2.03400   1.000 14.50000  ? 176 LEU A CB   1 
ATOM   2653 C CG   . LEU A 1 176 ? 15.10900  -31.97500 1.63500   1.000 16.28000  ? 176 LEU A CG   1 
ATOM   2654 C CD1  . LEU A 1 176 ? 14.98800  -32.55800 0.23600   1.000 17.31000  ? 176 LEU A CD1  1 
ATOM   2655 C CD2  . LEU A 1 176 ? 16.30900  -31.04600 1.72500   1.000 15.16000  ? 176 LEU A CD2  1 
ATOM   2656 H H    . LEU A 1 176 ? 12.08600  -30.96900 0.15700   1.000 15.33000  ? 176 LEU A H    1 
ATOM   2657 H HA   . LEU A 1 176 ? 12.74200  -33.10400 2.10900   1.000 16.20000  ? 176 LEU A HA   1 
ATOM   2658 H HB2  . LEU A 1 176 ? 13.73400  -30.35600 1.40600   1.000 17.42000  ? 176 LEU A HB2  1 
ATOM   2659 H HB3  . LEU A 1 176 ? 13.93800  -30.90000 3.06300   1.000 17.42000  ? 176 LEU A HB3  1 
ATOM   2660 H HG   . LEU A 1 176 ? 15.26100  -32.79600 2.33400   1.000 19.56000  ? 176 LEU A HG   1 
ATOM   2661 H HD11 . LEU A 1 176 ? 15.97800  -32.82300 -0.13400  1.000 20.79000  ? 176 LEU A HD11 1 
ATOM   2662 H HD12 . LEU A 1 176 ? 14.36300  -33.45000 0.26700   1.000 20.79000  ? 176 LEU A HD12 1 
ATOM   2663 H HD13 . LEU A 1 176 ? 14.53700  -31.82100 -0.42600  1.000 20.79000  ? 176 LEU A HD13 1 
ATOM   2664 H HD21 . LEU A 1 176 ? 17.22300  -31.61500 1.55700   1.000 18.21000  ? 176 LEU A HD21 1 
ATOM   2665 H HD22 . LEU A 1 176 ? 16.22400  -30.26700 0.96900   1.000 18.21000  ? 176 LEU A HD22 1 
ATOM   2666 H HD23 . LEU A 1 176 ? 16.34200  -30.59000 2.71300   1.000 18.21000  ? 176 LEU A HD23 1 
ATOM   2667 N N    . ARG A 1 177 ? 11.27500  -32.33900 3.98800   1.000 14.49000  ? 177 ARG A N    1 
ATOM   2668 C CA   A ARG A 1 177 ? 10.39200  -31.90500 5.10200   0.390 13.82000  ? 177 ARG A CA   1 
ATOM   2669 C CA   B ARG A 1 177 ? 10.39400  -31.90700 5.10200   0.610 13.57000  ? 177 ARG A CA   1 
ATOM   2670 C C    . ARG A 1 177 ? 11.29800  -31.70000 6.33100   1.000 15.14000  ? 177 ARG A C    1 
ATOM   2671 O O    . ARG A 1 177 ? 11.86900  -32.64800 6.91800   1.000 15.90000  ? 177 ARG A O    1 
ATOM   2672 C CB   A ARG A 1 177 ? 9.30800   -32.94800 5.36900   0.390 16.72000  ? 177 ARG A CB   1 
ATOM   2673 C CB   B ARG A 1 177 ? 9.32500   -32.96100 5.37700   0.610 17.03000  ? 177 ARG A CB   1 
ATOM   2674 C CG   A ARG A 1 177 ? 8.70000   -33.53700 4.10400   0.390 18.59000  ? 177 ARG A CG   1 
ATOM   2675 C CG   B ARG A 1 177 ? 8.18100   -32.44600 6.22900   0.610 20.31000  ? 177 ARG A CG   1 
ATOM   2676 C CD   A ARG A 1 177 ? 7.28200   -34.05900 4.25700   0.390 20.37000  ? 177 ARG A CD   1 
ATOM   2677 C CD   B ARG A 1 177 ? 7.08900   -33.48000 6.35000   0.610 26.44000  ? 177 ARG A CD   1 
ATOM   2678 N NE   A ARG A 1 177 ? 6.43800   -33.15500 5.01000   0.390 18.48000  ? 177 ARG A NE   1 
ATOM   2679 N NE   B ARG A 1 177 ? 6.23400   -33.44400 5.17200   0.610 21.13000  ? 177 ARG A NE   1 
ATOM   2680 C CZ   A ARG A 1 177 ? 6.24200   -33.17500 6.31800   0.390 26.01000  ? 177 ARG A CZ   1 
ATOM   2681 C CZ   B ARG A 1 177 ? 5.60000   -34.48400 4.63700   0.610 18.05000  ? 177 ARG A CZ   1 
ATOM   2682 N NH1  A ARG A 1 177 ? 6.82800   -34.06600 7.09400   0.390 29.91000  ? 177 ARG A NH1  1 
ATOM   2683 N NH1  B ARG A 1 177 ? 5.70000   -35.69800 5.15500   0.610 19.32000  ? 177 ARG A NH1  1 
ATOM   2684 N NH2  A ARG A 1 177 ? 5.45900   -32.27200 6.87000   0.390 34.87000  ? 177 ARG A NH2  1 
ATOM   2685 N NH2  B ARG A 1 177 ? 4.84800   -34.30100 3.56800   0.610 18.63000  ? 177 ARG A NH2  1 
ATOM   2686 H H    A ARG A 1 177 ? 12.02000  -32.96300 4.34900   0.390 17.41000  ? 177 ARG A H    1 
ATOM   2687 H H    B ARG A 1 177 ? 12.02200  -32.95900 4.35100   0.610 17.41000  ? 177 ARG A H    1 
ATOM   2688 H HA   A ARG A 1 177 ? 9.92200   -30.95900 4.84200   0.390 16.61000  ? 177 ARG A HA   1 
ATOM   2689 H HA   B ARG A 1 177 ? 9.91500   -30.96400 4.84300   0.610 16.31000  ? 177 ARG A HA   1 
ATOM   2690 H HB2  A ARG A 1 177 ? 9.73600   -33.75500 5.96200   0.390 20.09000  ? 177 ARG A HB2  1 
ATOM   2691 H HB2  B ARG A 1 177 ? 8.92800   -33.31500 4.42700   0.610 20.46000  ? 177 ARG A HB2  1 
ATOM   2692 H HB3  A ARG A 1 177 ? 8.53100   -32.47200 5.96100   0.390 20.09000  ? 177 ARG A HB3  1 
ATOM   2693 H HB3  B ARG A 1 177 ? 9.79000   -33.80400 5.88400   0.610 20.46000  ? 177 ARG A HB3  1 
ATOM   2694 H HG2  A ARG A 1 177 ? 8.70200   -32.77500 3.32700   0.390 22.32000  ? 177 ARG A HG2  1 
ATOM   2695 H HG2  B ARG A 1 177 ? 8.54700   -32.18900 7.22200   0.610 24.39000  ? 177 ARG A HG2  1 
ATOM   2696 H HG3  A ARG A 1 177 ? 9.33200   -34.35600 3.76100   0.390 22.32000  ? 177 ARG A HG3  1 
ATOM   2697 H HG3  B ARG A 1 177 ? 7.77300   -31.54800 5.76800   0.610 24.39000  ? 177 ARG A HG3  1 
ATOM   2698 H HD2  A ARG A 1 177 ? 6.84600   -34.18300 3.26800   0.390 24.47000  ? 177 ARG A HD2  1 
ATOM   2699 H HD2  B ARG A 1 177 ? 7.54700   -34.46000 6.45100   0.610 31.75000  ? 177 ARG A HD2  1 
ATOM   2700 H HD3  A ARG A 1 177 ? 7.30200   -35.03500 4.73500   0.390 24.47000  ? 177 ARG A HD3  1 
ATOM   2701 H HD3  B ARG A 1 177 ? 6.49600   -33.28500 7.24100   0.610 31.75000  ? 177 ARG A HD3  1 
ATOM   2702 H HE   A ARG A 1 177 ? 5.96400   -32.43000 4.48600   0.390 22.20000  ? 177 ARG A HE   1 
ATOM   2703 H HE   B ARG A 1 177 ? 6.10900   -32.54400 4.71800   0.610 25.37000  ? 177 ARG A HE   1 
ATOM   2704 H HH11 A ARG A 1 177 ? 7.44600   -34.77800 6.71600   0.390 35.91000  ? 177 ARG A HH11 1 
ATOM   2705 H HH11 B ARG A 1 177 ? 6.26300   -35.87100 5.98100   0.610 23.20000  ? 177 ARG A HH11 1 
ATOM   2706 H HH12 A ARG A 1 177 ? 6.63600   -34.03000 8.08900   0.390 35.91000  ? 177 ARG A HH12 1 
ATOM   2707 H HH12 B ARG A 1 177 ? 5.19900   -36.46700 4.71900   0.610 23.20000  ? 177 ARG A HH12 1 
ATOM   2708 H HH21 A ARG A 1 177 ? 5.00600   -31.56500 6.29800   0.390 41.86000  ? 177 ARG A HH21 1 
ATOM   2709 H HH21 B ARG A 1 177 ? 4.76800   -33.37400 3.16100   0.610 22.38000  ? 177 ARG A HH21 1 
ATOM   2710 H HH22 A ARG A 1 177 ? 5.33200   -32.28600 7.87600   0.390 41.86000  ? 177 ARG A HH22 1 
ATOM   2711 H HH22 B ARG A 1 177 ? 4.36300   -35.09000 3.14900   0.610 22.38000  ? 177 ARG A HH22 1 
ATOM   2712 N N    . LEU A 1 178 ? 11.54000  -30.44100 6.66500   1.000 15.03000  ? 178 LEU A N    1 
ATOM   2713 C CA   . LEU A 1 178 ? 12.43200  -30.10200 7.79700   1.000 15.54000  ? 178 LEU A CA   1 
ATOM   2714 C C    . LEU A 1 178 ? 11.61200  -29.90700 9.06600   1.000 15.03000  ? 178 LEU A C    1 
ATOM   2715 O O    . LEU A 1 178 ? 10.78000  -29.03900 9.09800   1.000 16.60000  ? 178 LEU A O    1 
ATOM   2716 C CB   . LEU A 1 178 ? 13.20000  -28.81700 7.48400   1.000 15.40000  ? 178 LEU A CB   1 
ATOM   2717 C CG   . LEU A 1 178 ? 14.03600  -28.83000 6.20700   1.000 22.38000  ? 178 LEU A CG   1 
ATOM   2718 C CD1  . LEU A 1 178 ? 14.85500  -27.55500 6.09700   1.000 20.68000  ? 178 LEU A CD1  1 
ATOM   2719 C CD2  . LEU A 1 178 ? 14.94200  -30.04800 6.15300   1.000 24.29000  ? 178 LEU A CD2  1 
ATOM   2720 H H    . LEU A 1 178 ? 11.13000  -29.63000 6.17400   1.000 18.06000  ? 178 LEU A H    1 
ATOM   2721 H HA   . LEU A 1 178 ? 13.13600  -30.91800 7.95200   1.000 18.67000  ? 178 LEU A HA   1 
ATOM   2722 H HB2  . LEU A 1 178 ? 12.48100  -28.00200 7.41400   1.000 18.50000  ? 178 LEU A HB2  1 
ATOM   2723 H HB3  . LEU A 1 178 ? 13.85800  -28.60200 8.32400   1.000 18.50000  ? 178 LEU A HB3  1 
ATOM   2724 H HG   . LEU A 1 178 ? 13.35600  -28.87200 5.35700   1.000 26.87000  ? 178 LEU A HG   1 
ATOM   2725 H HD11 . LEU A 1 178 ? 14.97700  -27.29100 5.04800   1.000 24.83000  ? 178 LEU A HD11 1 
ATOM   2726 H HD12 . LEU A 1 178 ? 14.34100  -26.74700 6.61700   1.000 24.83000  ? 178 LEU A HD12 1 
ATOM   2727 H HD13 . LEU A 1 178 ? 15.83400  -27.71200 6.54800   1.000 24.83000  ? 178 LEU A HD13 1 
ATOM   2728 H HD21 . LEU A 1 178 ? 15.75600  -29.86400 5.45300   1.000 29.17000  ? 178 LEU A HD21 1 
ATOM   2729 H HD22 . LEU A 1 178 ? 15.35100  -30.24000 7.14300   1.000 29.17000  ? 178 LEU A HD22 1 
ATOM   2730 H HD23 . LEU A 1 178 ? 14.36700  -30.91300 5.82400   1.000 29.17000  ? 178 LEU A HD23 1 
ATOM   2731 N N    . PHE A 1 179 ? 11.86900  -30.72100 10.06300  1.000 15.29000  ? 179 PHE A N    1 
ATOM   2732 C CA   . PHE A 1 179 ? 11.21200  -30.55400 11.36500  1.000 14.90000  ? 179 PHE A CA   1 
ATOM   2733 C C    . PHE A 1 179 ? 12.05900  -29.60100 12.18600  1.000 17.03000  ? 179 PHE A C    1 
ATOM   2734 O O    . PHE A 1 179 ? 13.13400  -29.96500 12.67000  1.000 18.42000  ? 179 PHE A O    1 
ATOM   2735 C CB   . PHE A 1 179 ? 11.05200  -31.92700 12.01800  1.000 16.55000  ? 179 PHE A CB   1 
ATOM   2736 C CG   . PHE A 1 179 ? 10.08000  -32.83500 11.27200  1.000 20.68000  ? 179 PHE A CG   1 
ATOM   2737 C CD1  . PHE A 1 179 ? 10.48200  -33.47100 10.12800  1.000 18.33000  ? 179 PHE A CD1  1 
ATOM   2738 C CD2  . PHE A 1 179 ? 8.74300   -32.98300 11.68900  1.000 19.26000  ? 179 PHE A CD2  1 
ATOM   2739 C CE1  . PHE A 1 179 ? 9.61000   -34.27800 9.46000   1.000 19.10000  ? 179 PHE A CE1  1 
ATOM   2740 C CE2  . PHE A 1 179 ? 7.88700   -33.79600 11.01800  1.000 21.39000  ? 179 PHE A CE2  1 
ATOM   2741 C CZ   . PHE A 1 179 ? 8.30800   -34.45000 9.88600   1.000 20.77000  ? 179 PHE A CZ   1 
ATOM   2742 H H    . PHE A 1 179 ? 12.42800  -31.37400 10.02900  1.000 18.37000  ? 179 PHE A H    1 
ATOM   2743 H HA   . PHE A 1 179 ? 10.33300  -30.15400 11.27200  1.000 17.89000  ? 179 PHE A HA   1 
ATOM   2744 H HB2  . PHE A 1 179 ? 11.91600  -32.36700 12.04000  1.000 19.88000  ? 179 PHE A HB2  1 
ATOM   2745 H HB3  . PHE A 1 179 ? 10.71700  -31.80800 12.92100  1.000 19.88000  ? 179 PHE A HB3  1 
ATOM   2746 H HD1  . PHE A 1 179 ? 11.34800  -33.35400 9.80900   1.000 22.02000  ? 179 PHE A HD1  1 
ATOM   2747 H HD2  . PHE A 1 179 ? 8.44300   -32.51700 12.43600  1.000 23.13000  ? 179 PHE A HD2  1 
ATOM   2748 H HE1  . PHE A 1 179 ? 9.89900   -34.72400 8.69700   1.000 22.94000  ? 179 PHE A HE1  1 
ATOM   2749 H HE2  . PHE A 1 179 ? 7.01600   -33.90900 11.32400  1.000 25.69000  ? 179 PHE A HE2  1 
ATOM   2750 H HZ   . PHE A 1 179 ? 7.72500   -35.00000 9.41400   1.000 24.95000  ? 179 PHE A HZ   1 
ATOM   2751 N N    . LEU A 1 180 ? 11.63300  -28.34600 12.24400  1.000 17.20000  ? 180 LEU A N    1 
ATOM   2752 C CA   . LEU A 1 180 ? 12.51200  -27.29800 12.75400  1.000 17.38000  ? 180 LEU A CA   1 
ATOM   2753 C C    . LEU A 1 180 ? 12.69100  -27.40600 14.27900  1.000 18.64000  ? 180 LEU A C    1 
ATOM   2754 O O    . LEU A 1 180 ? 11.77700  -27.79300 15.00200  1.000 20.20000  ? 180 LEU A O    1 
ATOM   2755 C CB   . LEU A 1 180 ? 11.90700  -25.92800 12.44600  1.000 17.30000  ? 180 LEU A CB   1 
ATOM   2756 C CG   . LEU A 1 180 ? 11.79500  -25.60700 10.95800  1.000 15.73000  ? 180 LEU A CG   1 
ATOM   2757 C CD1  . LEU A 1 180 ? 11.15700  -24.27900 10.84100  1.000 17.78000  ? 180 LEU A CD1  1 
ATOM   2758 C CD2  . LEU A 1 180 ? 13.20500  -25.60800 10.37400  1.000 19.13000  ? 180 LEU A CD2  1 
ATOM   2759 H H    . LEU A 1 180 ? 10.85400  -28.07700 12.00000  1.000 20.66000  ? 180 LEU A H    1 
ATOM   2760 H HA   . LEU A 1 180 ? 13.38100  -27.38600 12.33200  1.000 20.88000  ? 180 LEU A HA   1 
ATOM   2761 H HB2  . LEU A 1 180 ? 11.01300  -25.89400 12.82200  1.000 20.78000  ? 180 LEU A HB2  1 
ATOM   2762 H HB3  . LEU A 1 180 ? 12.46400  -25.24600 12.85300  1.000 20.78000  ? 180 LEU A HB3  1 
ATOM   2763 H HG   . LEU A 1 180 ? 11.26300  -26.25100 10.46500  1.000 18.90000  ? 180 LEU A HG   1 
ATOM   2764 H HD11 . LEU A 1 180 ? 10.98400  -24.09300 9.90500   1.000 21.36000  ? 180 LEU A HD11 1 
ATOM   2765 H HD12 . LEU A 1 180 ? 10.32300  -24.28500 11.33600  1.000 21.36000  ? 180 LEU A HD12 1 
ATOM   2766 H HD13 . LEU A 1 180 ? 11.75400  -23.60800 11.20600  1.000 21.36000  ? 180 LEU A HD13 1 
ATOM   2767 H HD21 . LEU A 1 180 ? 13.22500  -25.03100 9.59500   1.000 22.98000  ? 180 LEU A HD21 1 
ATOM   2768 H HD22 . LEU A 1 180 ? 13.82500  -25.28000 11.04400  1.000 22.98000  ? 180 LEU A HD22 1 
ATOM   2769 H HD23 . LEU A 1 180 ? 13.44100  -26.51400 10.12000  1.000 22.98000  ? 180 LEU A HD23 1 
ATOM   2770 N N    . LYS A 1 181 ? 13.87100  -26.97700 14.71800  1.000 17.51000  ? 181 LYS A N    1 
ATOM   2771 C CA   . LYS A 1 181 ? 14.18000  -26.87400 16.15700  1.000 19.81000  ? 181 LYS A CA   1 
ATOM   2772 C C    . LYS A 1 181 ? 13.21600  -25.85000 16.73500  1.000 18.98000  ? 181 LYS A C    1 
ATOM   2773 O O    . LYS A 1 181 ? 12.89500  -24.91400 16.02500  1.000 19.16000  ? 181 LYS A O    1 
ATOM   2774 C CB   . LYS A 1 181 ? 15.65400  -26.52100 16.34800  1.000 20.30000  ? 181 LYS A CB   1 
ATOM   2775 C CG   . LYS A 1 181 ? 16.64500  -27.58700 15.89900  1.000 22.09000  ? 181 LYS A CG   1 
ATOM   2776 C CD   . LYS A 1 181 ? 18.05200  -27.05800 15.71000  1.000 22.91000  ? 181 LYS A CD   1 
ATOM   2777 C CE   . LYS A 1 181 ? 19.07800  -28.14600 15.47700  1.000 24.32000  ? 181 LYS A CE   1 
ATOM   2778 N NZ   . LYS A 1 181 ? 20.46000  -27.61700 15.52200  1.000 27.09000  ? 181 LYS A NZ   1 
ATOM   2779 H H    . LYS A 1 181 ? 14.64400  -26.68700 14.09500  1.000 21.03000  ? 181 LYS A H    1 
ATOM   2780 H HA   . LYS A 1 181 ? 13.98600  -27.83900 16.62300  1.000 23.79000  ? 181 LYS A HA   1 
ATOM   2781 H HB2  . LYS A 1 181 ? 15.86000  -25.60500 15.79600  1.000 24.38000  ? 181 LYS A HB2  1 
ATOM   2782 H HB3  . LYS A 1 181 ? 15.82200  -26.31500 17.40400  1.000 24.38000  ? 181 LYS A HB3  1 
ATOM   2783 H HG2  . LYS A 1 181 ? 16.66100  -28.38600 16.63800  1.000 26.53000  ? 181 LYS A HG2  1 
ATOM   2784 H HG3  . LYS A 1 181 ? 16.29900  -28.01100 14.95700  1.000 26.53000  ? 181 LYS A HG3  1 
ATOM   2785 H HD2  . LYS A 1 181 ? 18.06300  -26.38100 14.85700  1.000 27.52000  ? 181 LYS A HD2  1 
ATOM   2786 H HD3  . LYS A 1 181 ? 18.33800  -26.48800 16.59200  1.000 27.52000  ? 181 LYS A HD3  1 
ATOM   2787 H HE2  . LYS A 1 181 ? 18.96900  -28.92000 16.23600  1.000 29.21000  ? 181 LYS A HE2  1 
ATOM   2788 H HE3  . LYS A 1 181 ? 18.90600  -28.60200 14.50300  1.000 29.21000  ? 181 LYS A HE3  1 
ATOM   2789 H HZ1  . LYS A 1 181 ? 21.13600  -28.38900 15.36900  1.000 32.53000  ? 181 LYS A HZ1  1 
ATOM   2790 H HZ2  . LYS A 1 181 ? 20.58500  -26.90500 14.78000  1.000 32.53000  ? 181 LYS A HZ2  1 
ATOM   2791 H HZ3  . LYS A 1 181 ? 20.63900  -27.18200 16.44400  1.000 32.53000  ? 181 LYS A HZ3  1 
ATOM   2792 N N    A GLU A 1 182 ? 13.05200  -25.85900 18.05700  0.650 23.05000  ? 182 GLU A N    1 
ATOM   2793 N N    B GLU A 1 182 ? 13.05200  -25.86300 18.05800  0.350 22.84000  ? 182 GLU A N    1 
ATOM   2794 C CA   A GLU A 1 182 ? 12.05900  -24.95600 18.69200  0.650 24.92000  ? 182 GLU A CA   1 
ATOM   2795 C CA   B GLU A 1 182 ? 12.06500  -24.95700 18.70100  0.350 24.86000  ? 182 GLU A CA   1 
ATOM   2796 C C    A GLU A 1 182 ? 12.47900  -23.48700 18.63700  0.650 23.34000  ? 182 GLU A C    1 
ATOM   2797 C C    B GLU A 1 182 ? 12.47700  -23.49200 18.61700  0.350 23.58000  ? 182 GLU A C    1 
ATOM   2798 O O    A GLU A 1 182 ? 11.59600  -22.63500 18.57000  0.650 25.16000  ? 182 GLU A O    1 
ATOM   2799 O O    B GLU A 1 182 ? 11.58600  -22.63800 18.55300  0.350 25.12000  ? 182 GLU A O    1 
ATOM   2800 C CB   A GLU A 1 182 ? 11.87100  -25.39800 20.14200  0.650 25.01000  ? 182 GLU A CB   1 
ATOM   2801 C CB   B GLU A 1 182 ? 11.92300  -25.34400 20.17800  0.350 25.54000  ? 182 GLU A CB   1 
ATOM   2802 C CG   A GLU A 1 182 ? 10.98200  -26.61200 20.28600  0.650 31.38000  ? 182 GLU A CG   1 
ATOM   2803 C CG   B GLU A 1 182 ? 10.51100  -25.59900 20.67000  0.350 35.97000  ? 182 GLU A CG   1 
ATOM   2804 C CD   A GLU A 1 182 ? 9.61100   -26.41700 19.67000  0.650 43.47000  ? 182 GLU A CD   1 
ATOM   2805 C CD   B GLU A 1 182 ? 9.48300   -25.90200 19.60200  0.350 42.17000  ? 182 GLU A CD   1 
ATOM   2806 O OE1  A GLU A 1 182 ? 9.13700   -25.26900 19.67900  0.650 42.56000  ? 182 GLU A OE1  1 
ATOM   2807 O OE1  B GLU A 1 182 ? 8.98300   -24.93700 19.00500  0.350 42.12000  ? 182 GLU A OE1  1 
ATOM   2808 O OE2  A GLU A 1 182 ? 9.04300   -27.40000 19.16700  0.650 42.16000  ? 182 GLU A OE2  1 
ATOM   2809 O OE2  B GLU A 1 182 ? 9.21600   -27.09100 19.35100  0.350 47.31000  ? 182 GLU A OE2  1 
ATOM   2810 H H    A GLU A 1 182 ? 13.09600  -26.76000 18.56400  0.650 27.68000  ? 182 GLU A H    1 
ATOM   2811 H H    B GLU A 1 182 ? 13.08800  -26.76900 18.55400  0.350 27.42000  ? 182 GLU A H    1 
ATOM   2812 H HA   A GLU A 1 182 ? 11.11700  -25.06300 18.15800  0.650 29.92000  ? 182 GLU A HA   1 
ATOM   2813 H HA   B GLU A 1 182 ? 11.12300  -25.07500 18.17500  0.350 29.86000  ? 182 GLU A HA   1 
ATOM   2814 H HB2  A GLU A 1 182 ? 12.84800  -25.62200 20.56500  0.650 30.03000  ? 182 GLU A HB2  1 
ATOM   2815 H HB2  B GLU A 1 182 ? 12.51700  -26.23700 20.36300  0.350 30.67000  ? 182 GLU A HB2  1 
ATOM   2816 H HB3  A GLU A 1 182 ? 11.44100  -24.57100 20.70500  0.650 30.03000  ? 182 GLU A HB3  1 
ATOM   2817 H HB3  B GLU A 1 182 ? 12.35200  -24.54000 20.77300  0.350 30.67000  ? 182 GLU A HB3  1 
ATOM   2818 H HG2  A GLU A 1 182 ? 11.46100  -27.46500 19.80800  0.650 37.68000  ? 182 GLU A HG2  1 
ATOM   2819 H HG2  B GLU A 1 182 ? 10.53200  -26.43500 21.36600  0.350 43.18000  ? 182 GLU A HG2  1 
ATOM   2820 H HG3  A GLU A 1 182 ? 10.86100  -26.84400 21.34200  0.650 37.68000  ? 182 GLU A HG3  1 
ATOM   2821 H HG3  B GLU A 1 182 ? 10.17500  -24.72400 21.22400  0.350 43.18000  ? 182 GLU A HG3  1 
ATOM   2822 N N    . ASP A 1 183 ? 13.77800  -23.22700 18.50000  1.000 22.37000  ? 183 ASP A N    1 
ATOM   2823 C CA   . ASP A 1 183 ? 14.26500  -21.83000 18.48000  1.000 22.44000  ? 183 ASP A CA   1 
ATOM   2824 C C    . ASP A 1 183 ? 14.50900  -21.36100 17.04300  1.000 24.39000  ? 183 ASP A C    1 
ATOM   2825 O O    . ASP A 1 183 ? 15.05000  -20.27100 16.89100  1.000 23.74000  ? 183 ASP A O    1 
ATOM   2826 C CB   . ASP A 1 183 ? 15.51900  -21.65100 19.32600  1.000 29.05000  ? 183 ASP A CB   1 
ATOM   2827 C CG   . ASP A 1 183 ? 16.70000  -22.40500 18.79100  1.000 35.56000  ? 183 ASP A CG   1 
ATOM   2828 O OD1  . ASP A 1 183 ? 16.45800  -23.38200 18.07700  1.000 36.11000  ? 183 ASP A OD1  1 
ATOM   2829 O OD2  . ASP A 1 183 ? 17.82900  -21.99900 19.10500  1.000 47.14000  ? 183 ASP A OD2  1 
ATOM   2830 H H    . ASP A 1 183 ? 14.46500  -23.84800 18.96100  1.000 26.86000  ? 183 ASP A H    1 
ATOM   2831 H HA   . ASP A 1 183 ? 13.49500  -21.19600 18.91500  1.000 26.95000  ? 183 ASP A HA   1 
ATOM   2832 H HB2  . ASP A 1 183 ? 15.77400  -20.59400 19.37300  1.000 34.88000  ? 183 ASP A HB2  1 
ATOM   2833 H HB3  . ASP A 1 183 ? 15.31500  -22.00100 20.33700  1.000 34.88000  ? 183 ASP A HB3  1 
ATOM   2834 N N    . GLN A 1 184 ? 14.11200  -22.15100 16.03900  1.000 21.21000  ? 184 GLN A N    1 
ATOM   2835 C CA   . GLN A 1 184 ? 14.37300  -21.76200 14.65100  1.000 20.67000  ? 184 GLN A CA   1 
ATOM   2836 C C    . GLN A 1 184 ? 13.09000  -21.58900 13.87600  1.000 22.45000  ? 184 GLN A C    1 
ATOM   2837 O O    . GLN A 1 184 ? 13.06900  -21.70800 12.65000  1.000 20.92000  ? 184 GLN A O    1 
ATOM   2838 C CB   . GLN A 1 184 ? 15.27900  -22.77400 13.96300  1.000 18.59000  ? 184 GLN A CB   1 
ATOM   2839 C CG   . GLN A 1 184 ? 16.58300  -23.00900 14.69600  1.000 20.53000  ? 184 GLN A CG   1 
ATOM   2840 C CD   . GLN A 1 184 ? 17.44800  -21.77400 14.65900  1.000 24.29000  ? 184 GLN A CD   1 
ATOM   2841 O OE1  . GLN A 1 184 ? 17.45400  -20.98700 13.67200  1.000 22.59000  ? 184 GLN A OE1  1 
ATOM   2842 N NE2  . GLN A 1 184 ? 18.15400  -21.54100 15.76800  1.000 28.50000  ? 184 GLN A NE2  1 
ATOM   2843 H H    . GLN A 1 184 ? 13.67900  -22.88800 16.12800  1.000 25.47000  ? 184 GLN A H    1 
ATOM   2844 H HA   . GLN A 1 184 ? 14.83400  -20.90800 14.65700  1.000 24.82000  ? 184 GLN A HA   1 
ATOM   2845 H HB2  . GLN A 1 184 ? 14.81300  -23.62200 13.90500  1.000 22.33000  ? 184 GLN A HB2  1 
ATOM   2846 H HB3  . GLN A 1 184 ? 15.49100  -22.45000 13.07400  1.000 22.33000  ? 184 GLN A HB3  1 
ATOM   2847 H HG2  . GLN A 1 184 ? 16.39800  -23.22800 15.62300  1.000 24.66000  ? 184 GLN A HG2  1 
ATOM   2848 H HG3  . GLN A 1 184 ? 17.06500  -23.73600 14.27300  1.000 24.66000  ? 184 GLN A HG3  1 
ATOM   2849 H HE21 . GLN A 1 184 ? 18.09400  -22.08000 16.43600  1.000 34.22000  ? 184 GLN A HE21 1 
ATOM   2850 H HE22 . GLN A 1 184 ? 18.66800  -20.85400 15.81500  1.000 34.22000  ? 184 GLN A HE22 1 
ATOM   2851 N N    . LEU A 1 185 ? 12.01500  -21.28800 14.54300  1.000 19.63000  ? 185 LEU A N    1 
ATOM   2852 C CA   . LEU A 1 185 ? 10.71000  -21.18100 13.88800  1.000 20.62000  ? 185 LEU A CA   1 
ATOM   2853 C C    . LEU A 1 185 ? 10.56400  -19.89100 13.08000  1.000 18.06000  ? 185 LEU A C    1 
ATOM   2854 O O    . LEU A 1 185 ? 9.59100   -19.73200 12.32000  1.000 21.04000  ? 185 LEU A O    1 
ATOM   2855 C CB   . LEU A 1 185 ? 9.59900   -21.29400 14.94200  1.000 20.87000  ? 185 LEU A CB   1 
ATOM   2856 C CG   . LEU A 1 185 ? 9.60500   -22.59000 15.71300  1.000 23.08000  ? 185 LEU A CG   1 
ATOM   2857 C CD1  . LEU A 1 185 ? 8.36900   -22.65800 16.70000  1.000 26.18000  ? 185 LEU A CD1  1 
ATOM   2858 C CD2  . LEU A 1 185 ? 9.59100   -23.84100 14.85600  1.000 23.34000  ? 185 LEU A CD2  1 
ATOM   2859 H H    . LEU A 1 185 ? 11.99600  -21.13600 15.39000  1.000 23.57000  ? 185 LEU A H    1 
ATOM   2860 H HA   . LEU A 1 185 ? 10.59700  -21.91800 13.26800  1.000 24.76000  ? 185 LEU A HA   1 
ATOM   2861 H HB2  . LEU A 1 185 ? 9.70400   -20.57100 15.58000  1.000 25.06000  ? 185 LEU A HB2  1 
ATOM   2862 H HB3  . LEU A 1 185 ? 8.74100   -21.22200 14.49500  1.000 25.06000  ? 185 LEU A HB3  1 
ATOM   2863 H HG   . LEU A 1 185 ? 10.44500  -22.58900 16.19700  1.000 27.72000  ? 185 LEU A HG   1 
ATOM   2864 H HD11 . LEU A 1 185 ? 8.45800   -23.44200 17.26300  1.000 31.43000  ? 185 LEU A HD11 1 
ATOM   2865 H HD12 . LEU A 1 185 ? 8.35700   -21.85700 17.24700  1.000 31.43000  ? 185 LEU A HD12 1 
ATOM   2866 H HD13 . LEU A 1 185 ? 7.55200   -22.71500 16.18000  1.000 31.43000  ? 185 LEU A HD13 1 
ATOM   2867 H HD21 . LEU A 1 185 ? 9.23300   -24.57700 15.37800  1.000 28.03000  ? 185 LEU A HD21 1 
ATOM   2868 H HD22 . LEU A 1 185 ? 9.03400   -23.68500 14.07800  1.000 28.03000  ? 185 LEU A HD22 1 
ATOM   2869 H HD23 . LEU A 1 185 ? 10.49800  -24.04400 14.57800  1.000 28.03000  ? 185 LEU A HD23 1 
ATOM   2870 N N    . GLU A 1 186 ? 11.55700  -18.99200 13.10500  1.000 18.94000  ? 186 GLU A N    1 
ATOM   2871 C CA   . GLU A 1 186 ? 11.51300  -17.84900 12.21600  1.000 19.66000  ? 186 GLU A CA   1 
ATOM   2872 C C    . GLU A 1 186 ? 11.46300  -18.27900 10.73800  1.000 17.75000  ? 186 GLU A C    1 
ATOM   2873 O O    . GLU A 1 186 ? 11.00300  -17.52300 9.90200   1.000 18.22000  ? 186 GLU A O    1 
ATOM   2874 C CB   . GLU A 1 186 ? 12.74000  -16.92200 12.40500  1.000 20.90000  ? 186 GLU A CB   1 
ATOM   2875 C CG   . GLU A 1 186 ? 14.08600  -17.53400 12.01100  1.000 20.40000  ? 186 GLU A CG   1 
ATOM   2876 C CD   . GLU A 1 186 ? 15.27200  -16.81500 12.64700  1.000 22.04000  ? 186 GLU A CD   1 
ATOM   2877 O OE1  . GLU A 1 186 ? 15.40800  -16.90500 13.93600  1.000 25.61000  ? 186 GLU A OE1  1 
ATOM   2878 O OE2  . GLU A 1 186 ? 15.97500  -16.13800 11.89300  1.000 23.82000  ? 186 GLU A OE2  1 
ATOM   2879 H H    . GLU A 1 186 ? 12.24700  -19.02800 13.61800  1.000 22.74000  ? 186 GLU A H    1 
ATOM   2880 H HA   . GLU A 1 186 ? 10.71300  -17.35000 12.44600  1.000 23.61000  ? 186 GLU A HA   1 
ATOM   2881 H HB2  . GLU A 1 186 ? 12.61100  -16.12900 11.86100  1.000 25.10000  ? 186 GLU A HB2  1 
ATOM   2882 H HB3  . GLU A 1 186 ? 12.79600  -16.67600 13.34200  1.000 25.10000  ? 186 GLU A HB3  1 
ATOM   2883 H HG2  . GLU A 1 186 ? 14.10800  -18.46000 12.29700  1.000 24.50000  ? 186 GLU A HG2  1 
ATOM   2884 H HG3  . GLU A 1 186 ? 14.18600  -17.48200 11.04700  1.000 24.50000  ? 186 GLU A HG3  1 
ATOM   2885 N N    . TYR A 1 187 ? 12.00300  -19.45900 10.40100  1.000 18.04000  ? 187 TYR A N    1 
ATOM   2886 C CA   . TYR A 1 187 ? 12.04400  -19.88700 9.00100   1.000 16.79000  ? 187 TYR A CA   1 
ATOM   2887 C C    . TYR A 1 187 ? 10.70400  -20.43500 8.53900   1.000 20.91000  ? 187 TYR A C    1 
ATOM   2888 O O    . TYR A 1 187 ? 10.63800  -20.86600 7.36400   1.000 18.55000  ? 187 TYR A O    1 
ATOM   2889 C CB   . TYR A 1 187 ? 13.17100  -20.92800 8.81300   1.000 17.20000  ? 187 TYR A CB   1 
ATOM   2890 C CG   . TYR A 1 187 ? 14.51600  -20.28700 9.13800   1.000 16.02000  ? 187 TYR A CG   1 
ATOM   2891 C CD1  . TYR A 1 187 ? 15.01200  -19.28000 8.38100   1.000 17.51000  ? 187 TYR A CD1  1 
ATOM   2892 C CD2  . TYR A 1 187 ? 15.19000  -20.63800 10.28900  1.000 18.52000  ? 187 TYR A CD2  1 
ATOM   2893 C CE1  . TYR A 1 187 ? 16.17800  -18.59500 8.73400   1.000 18.05000  ? 187 TYR A CE1  1 
ATOM   2894 C CE2  . TYR A 1 187 ? 16.39000  -19.96400 10.65800  1.000 18.79000  ? 187 TYR A CE2  1 
ATOM   2895 C CZ   . TYR A 1 187 ? 16.86300  -18.99300 9.86200   1.000 20.02000  ? 187 TYR A CZ   1 
ATOM   2896 O OH   . TYR A 1 187 ? 18.01100  -18.30500 10.26000  1.000 21.57000  ? 187 TYR A OH   1 
ATOM   2897 H H    . TYR A 1 187 ? 12.34500  -20.01800 10.95800  1.000 21.66000  ? 187 TYR A H    1 
ATOM   2898 H HA   . TYR A 1 187 ? 12.25900  -19.13400 8.42900   1.000 20.17000  ? 187 TYR A HA   1 
ATOM   2899 H HB2  . TYR A 1 187 ? 13.02800  -21.67800 9.41100   1.000 20.65000  ? 187 TYR A HB2  1 
ATOM   2900 H HB3  . TYR A 1 187 ? 13.18400  -21.23500 7.89300   1.000 20.65000  ? 187 TYR A HB3  1 
ATOM   2901 H HD1  . TYR A 1 187 ? 14.56300  -19.03700 7.60300   1.000 21.03000  ? 187 TYR A HD1  1 
ATOM   2902 H HD2  . TYR A 1 187 ? 14.86000  -21.32100 10.82700  1.000 22.24000  ? 187 TYR A HD2  1 
ATOM   2903 H HE1  . TYR A 1 187 ? 16.48600  -17.88500 8.21800   1.000 21.68000  ? 187 TYR A HE1  1 
ATOM   2904 H HE2  . TYR A 1 187 ? 16.83800  -20.19400 11.44000  1.000 22.57000  ? 187 TYR A HE2  1 
ATOM   2905 H HH   . TYR A 1 187 ? 18.69700  -18.70800 9.98900   1.000 25.91000  ? 187 TYR A HH   1 
ATOM   2906 N N    . LEU A 1 188 ? 9.62200   -20.31600 9.34700   1.000 17.97000  ? 188 LEU A N    1 
ATOM   2907 C CA   . LEU A 1 188 ? 8.25300   -20.50800 8.87400   1.000 18.39000  ? 188 LEU A CA   1 
ATOM   2908 C C    . LEU A 1 188 ? 7.59600   -19.22300 8.41000   1.000 19.01000  ? 188 LEU A C    1 
ATOM   2909 O O    . LEU A 1 188 ? 6.46200   -19.25600 7.90100   1.000 20.48000  ? 188 LEU A O    1 
ATOM   2910 C CB   . LEU A 1 188 ? 7.41500   -21.12400 9.98800   1.000 20.91000  ? 188 LEU A CB   1 
ATOM   2911 C CG   . LEU A 1 188 ? 7.88300   -22.48400 10.48300  1.000 24.37000  ? 188 LEU A CG   1 
ATOM   2912 C CD1  . LEU A 1 188 ? 7.19600   -22.86100 11.79600  1.000 25.84000  ? 188 LEU A CD1  1 
ATOM   2913 C CD2  . LEU A 1 188 ? 7.69600   -23.60500 9.42800   1.000 26.79000  ? 188 LEU A CD2  1 
ATOM   2914 H H    . LEU A 1 188 ? 9.66900   -20.12100 10.18300  1.000 21.59000  ? 188 LEU A H    1 
ATOM   2915 H HA   . LEU A 1 188 ? 8.26300   -21.11800 8.12000   1.000 22.09000  ? 188 LEU A HA   1 
ATOM   2916 H HB2  . LEU A 1 188 ? 7.42700   -20.52000 10.74700  1.000 25.11000  ? 188 LEU A HB2  1 
ATOM   2917 H HB3  . LEU A 1 188 ? 6.50800   -21.23100 9.66300   1.000 25.11000  ? 188 LEU A HB3  1 
ATOM   2918 H HG   . LEU A 1 188 ? 8.83700   -22.41300 10.64600  1.000 29.26000  ? 188 LEU A HG   1 
ATOM   2919 H HD11 . LEU A 1 188 ? 7.50200   -23.74000 12.07100  1.000 31.03000  ? 188 LEU A HD11 1 
ATOM   2920 H HD12 . LEU A 1 188 ? 7.42500   -22.20400 12.47200  1.000 31.03000  ? 188 LEU A HD12 1 
ATOM   2921 H HD13 . LEU A 1 188 ? 6.23600   -22.87300 11.65800  1.000 31.03000  ? 188 LEU A HD13 1 
ATOM   2922 H HD21 . LEU A 1 188 ? 7.94400   -24.45500 9.82300   1.000 32.16000  ? 188 LEU A HD21 1 
ATOM   2923 H HD22 . LEU A 1 188 ? 6.76600   -23.62700 9.15300   1.000 32.16000  ? 188 LEU A HD22 1 
ATOM   2924 H HD23 . LEU A 1 188 ? 8.26300   -23.41600 8.66400   1.000 32.16000  ? 188 LEU A HD23 1 
ATOM   2925 N N    . GLU A 1 189 ? 8.23500   -18.08100 8.62200   1.000 18.84000  ? 189 GLU A N    1 
ATOM   2926 C CA   . GLU A 1 189 ? 7.61800   -16.80000 8.39000   1.000 20.12000  ? 189 GLU A CA   1 
ATOM   2927 C C    . GLU A 1 189 ? 7.89500   -16.28700 6.98600   1.000 18.06000  ? 189 GLU A C    1 
ATOM   2928 O O    . GLU A 1 189 ? 9.04600   -16.26100 6.54200   1.000 19.85000  ? 189 GLU A O    1 
ATOM   2929 C CB   . GLU A 1 189 ? 8.13700   -15.80600 9.42400   1.000 21.80000  ? 189 GLU A CB   1 
ATOM   2930 C CG   . GLU A 1 189 ? 7.84100   -16.10600 10.84900  1.000 22.09000  ? 189 GLU A CG   1 
ATOM   2931 C CD   . GLU A 1 189 ? 6.35300   -16.05000 11.16500  1.000 37.98000  ? 189 GLU A CD   1 
ATOM   2932 O OE1  . GLU A 1 189 ? 5.70000   -15.08200 10.71900  1.000 53.64000  ? 189 GLU A OE1  1 
ATOM   2933 O OE2  . GLU A 1 189 ? 5.83500   -16.94800 11.85800  1.000 48.84000  ? 189 GLU A OE2  1 
ATOM   2934 H H    . GLU A 1 189 ? 9.04500   -18.02800 8.90600   1.000 22.62000  ? 189 GLU A H    1 
ATOM   2935 H HA   . GLU A 1 189 ? 6.65600   -16.89100 8.46700   1.000 24.17000  ? 189 GLU A HA   1 
ATOM   2936 H HB2  . GLU A 1 189 ? 9.10200   -15.76000 9.33800   1.000 26.18000  ? 189 GLU A HB2  1 
ATOM   2937 H HB3  . GLU A 1 189 ? 7.74500   -14.94000 9.23000   1.000 26.18000  ? 189 GLU A HB3  1 
ATOM   2938 H HG2  . GLU A 1 189 ? 8.15900   -16.99800 11.05700  1.000 26.53000  ? 189 GLU A HG2  1 
ATOM   2939 H HG3  . GLU A 1 189 ? 8.29100   -15.45400 11.40900  1.000 26.53000  ? 189 GLU A HG3  1 
ATOM   2940 N N    . GLU A 1 190 ? 6.86200   -15.78700 6.31300   1.000 18.81000  ? 190 GLU A N    1 
ATOM   2941 C CA   . GLU A 1 190 ? 6.98100   -15.28200 4.96400   1.000 19.73000  ? 190 GLU A CA   1 
ATOM   2942 C C    . GLU A 1 190 ? 8.08200   -14.22500 4.85200   1.000 19.91000  ? 190 GLU A C    1 
ATOM   2943 O O    . GLU A 1 190 ? 8.90500   -14.25600 3.94100   1.000 19.24000  ? 190 GLU A O    1 
ATOM   2944 C CB   . GLU A 1 190 ? 5.60700   -14.70400 4.50200   1.000 22.57000  ? 190 GLU A CB   1 
ATOM   2945 C CG   . GLU A 1 190 ? 5.64100   -14.06700 3.16800   1.000 22.30000  ? 190 GLU A CG   1 
ATOM   2946 C CD   . GLU A 1 190 ? 4.28100   -13.42200 2.76700   1.000 25.29000  ? 190 GLU A CD   1 
ATOM   2947 O OE1  . GLU A 1 190 ? 3.42100   -13.24900 3.65200   1.000 25.17000  ? 190 GLU A OE1  1 
ATOM   2948 O OE2  . GLU A 1 190 ? 4.12900   -13.09500 1.57900   1.000 29.84000  ? 190 GLU A OE2  1 
ATOM   2949 H H    . GLU A 1 190 ? 6.06400   -15.73000 6.62900   1.000 22.59000  ? 190 GLU A H    1 
ATOM   2950 H HA   . GLU A 1 190 ? 7.22100   -16.01400 4.37500   1.000 23.70000  ? 190 GLU A HA   1 
ATOM   2951 H HB2  . GLU A 1 190 ? 4.96200   -15.42700 4.46700   1.000 27.10000  ? 190 GLU A HB2  1 
ATOM   2952 H HB3  . GLU A 1 190 ? 5.32100   -14.03400 5.14200   1.000 27.10000  ? 190 GLU A HB3  1 
ATOM   2953 H HG2  . GLU A 1 190 ? 6.31500   -13.36800 3.16900   1.000 26.78000  ? 190 GLU A HG2  1 
ATOM   2954 H HG3  . GLU A 1 190 ? 5.86100   -14.73800 2.50300   1.000 26.78000  ? 190 GLU A HG3  1 
ATOM   2955 N N    . LYS A 1 191 ? 8.08300   -13.26400 5.76100   1.000 20.27000  ? 191 LYS A N    1 
ATOM   2956 C CA   . LYS A 1 191 ? 9.02500   -12.15700 5.65100   1.000 19.02000  ? 191 LYS A CA   1 
ATOM   2957 C C    . LYS A 1 191 ? 10.47200  -12.62600 5.74500   1.000 18.64000  ? 191 LYS A C    1 
ATOM   2958 O O    . LYS A 1 191 ? 11.32700  -12.21700 4.94200   1.000 20.66000  ? 191 LYS A O    1 
ATOM   2959 C CB   . LYS A 1 191 ? 8.67400   -11.14000 6.73800   1.000 24.81000  ? 191 LYS A CB   1 
ATOM   2960 C CG   . LYS A 1 191 ? 9.58800   -9.90600  6.76200   1.000 44.09000  ? 191 LYS A CG   1 
ATOM   2961 C CD   . LYS A 1 191 ? 9.41000   -9.14100  8.08600   1.000 45.74000  ? 191 LYS A CD   1 
ATOM   2962 C CE   . LYS A 1 191 ? 10.42000  -7.98800  8.21400   1.000 45.33000  ? 191 LYS A CE   1 
ATOM   2963 N NZ   . LYS A 1 191 ? 9.81400   -6.82600  8.90400   1.000 71.94000  ? 191 LYS A NZ   1 
ATOM   2964 H H    . LYS A 1 191 ? 7.55900   -13.22600 6.44200   1.000 24.35000  ? 191 LYS A H    1 
ATOM   2965 H HA   . LYS A 1 191 ? 8.94700   -11.72900 4.78400   1.000 22.84000  ? 191 LYS A HA   1 
ATOM   2966 H HB2  . LYS A 1 191 ? 7.76600   -10.83100 6.59300   1.000 29.79000  ? 191 LYS A HB2  1 
ATOM   2967 H HB3  . LYS A 1 191 ? 8.74300   -11.57400 7.60300   1.000 29.79000  ? 191 LYS A HB3  1 
ATOM   2968 H HG2  . LYS A 1 191 ? 10.51400  -10.18500 6.68600   1.000 52.93000  ? 191 LYS A HG2  1 
ATOM   2969 H HG3  . LYS A 1 191 ? 9.35800   -9.31500  6.02800   1.000 52.93000  ? 191 LYS A HG3  1 
ATOM   2970 H HD2  . LYS A 1 191 ? 8.51600   -8.76700  8.12300   1.000 54.90000  ? 191 LYS A HD2  1 
ATOM   2971 H HD3  . LYS A 1 191 ? 9.54700   -9.74900  8.82900   1.000 54.90000  ? 191 LYS A HD3  1 
ATOM   2972 H HE2  . LYS A 1 191 ? 11.18600  -8.28500  8.72800   1.000 54.42000  ? 191 LYS A HE2  1 
ATOM   2973 H HE3  . LYS A 1 191 ? 10.70300  -7.70600  7.33000   1.000 54.42000  ? 191 LYS A HE3  1 
ATOM   2974 H HZ1  . LYS A 1 191 ? 10.42500  -6.19000  9.02400   1.000 86.34000  ? 191 LYS A HZ1  1 
ATOM   2975 H HZ2  . LYS A 1 191 ? 9.14500   -6.49700  8.41700   1.000 86.34000  ? 191 LYS A HZ2  1 
ATOM   2976 H HZ3  . LYS A 1 191 ? 9.49700   -7.07500  9.69800   1.000 86.34000  ? 191 LYS A HZ3  1 
ATOM   2977 N N    . ARG A 1 192 ? 10.73300  -13.53900 6.66200   1.000 19.54000  ? 192 ARG A N    1 
ATOM   2978 C CA   . ARG A 1 192 ? 12.06800  -14.07300 6.86700   1.000 20.50000  ? 192 ARG A CA   1 
ATOM   2979 C C    . ARG A 1 192 ? 12.51200  -14.92200 5.68600   1.000 18.96000  ? 192 ARG A C    1 
ATOM   2980 O O    . ARG A 1 192 ? 13.65000  -14.82500 5.22700   1.000 17.80000  ? 192 ARG A O    1 
ATOM   2981 C CB   . ARG A 1 192 ? 12.07900  -14.91700 8.13900   1.000 19.50000  ? 192 ARG A CB   1 
ATOM   2982 C CG   . ARG A 1 192 ? 13.44300  -15.45900 8.52200   1.000 18.63000  ? 192 ARG A CG   1 
ATOM   2983 C CD   . ARG A 1 192 ? 14.33700  -14.31700 9.08600   1.000 24.60000  ? 192 ARG A CD   1 
ATOM   2984 N NE   . ARG A 1 192 ? 15.64900  -14.85900 9.39300   1.000 21.66000  ? 192 ARG A NE   1 
ATOM   2985 C CZ   . ARG A 1 192 ? 16.78400  -14.56000 8.80300   1.000 20.19000  ? 192 ARG A CZ   1 
ATOM   2986 N NH1  . ARG A 1 192 ? 16.85400  -13.62400 7.87800   1.000 24.69000  ? 192 ARG A NH1  1 
ATOM   2987 N NH2  . ARG A 1 192 ? 17.87200  -15.26200 9.09400   1.000 24.97000  ? 192 ARG A NH2  1 
ATOM   2988 H H    . ARG A 1 192 ? 10.14400  -13.87500 7.19200   1.000 23.47000  ? 192 ARG A H    1 
ATOM   2989 H HA   . ARG A 1 192 ? 12.69100  -13.33600 6.96400   1.000 24.62000  ? 192 ARG A HA   1 
ATOM   2990 H HB2  . ARG A 1 192 ? 11.76400  -14.37100 8.87600   1.000 23.41000  ? 192 ARG A HB2  1 
ATOM   2991 H HB3  . ARG A 1 192 ? 11.48800  -15.67600 8.01200   1.000 23.41000  ? 192 ARG A HB3  1 
ATOM   2992 H HG2  . ARG A 1 192 ? 13.34300  -16.14000 9.20400   1.000 22.37000  ? 192 ARG A HG2  1 
ATOM   2993 H HG3  . ARG A 1 192 ? 13.87600  -15.83400 7.73900   1.000 22.37000  ? 192 ARG A HG3  1 
ATOM   2994 H HD2  . ARG A 1 192 ? 14.43300  -13.61300 8.42500   1.000 29.54000  ? 192 ARG A HD2  1 
ATOM   2995 H HD3  . ARG A 1 192 ? 13.94500  -13.95800 9.89700   1.000 29.54000  ? 192 ARG A HD3  1 
ATOM   2996 H HE   . ARG A 1 192 ? 15.68700  -15.43600 10.02900  1.000 26.02000  ? 192 ARG A HE   1 
ATOM   2997 H HH11 . ARG A 1 192 ? 16.14600  -13.19200 7.64800   1.000 29.65000  ? 192 ARG A HH11 1 
ATOM   2998 H HH12 . ARG A 1 192 ? 17.60700  -13.44400 7.50400   1.000 29.65000  ? 192 ARG A HH12 1 
ATOM   2999 H HH21 . ARG A 1 192 ? 17.82900  -15.90500 9.66400   1.000 29.99000  ? 192 ARG A HH21 1 
ATOM   3000 H HH22 . ARG A 1 192 ? 18.62000  -15.07500 8.71300   1.000 29.99000  ? 192 ARG A HH22 1 
ATOM   3001 N N    . ILE A 1 193 ? 11.63600  -15.80700 5.20100   1.000 18.33000  ? 193 ILE A N    1 
ATOM   3002 C CA   . ILE A 1 193 ? 11.98700  -16.61900 4.06600   1.000 18.07000  ? 193 ILE A CA   1 
ATOM   3003 C C    . ILE A 1 193 ? 12.36300  -15.72300 2.88400   1.000 19.43000  ? 193 ILE A C    1 
ATOM   3004 O O    . ILE A 1 193 ? 13.36200  -15.95200 2.20100   1.000 19.21000  ? 193 ILE A O    1 
ATOM   3005 C CB   . ILE A 1 193 ? 10.82200  -17.59600 3.72900   1.000 18.00000  ? 193 ILE A CB   1 
ATOM   3006 C CG1  . ILE A 1 193 ? 10.62100  -18.60400 4.86800   1.000 18.25000  ? 193 ILE A CG1  1 
ATOM   3007 C CG2  . ILE A 1 193 ? 11.11600  -18.26000 2.34200   1.000 18.42000  ? 193 ILE A CG2  1 
ATOM   3008 C CD1  . ILE A 1 193 ? 9.29600   -19.31200 4.80300   1.000 18.51000  ? 193 ILE A CD1  1 
ATOM   3009 H H    . ILE A 1 193 ? 10.84800  -15.94600 5.51600   1.000 22.02000  ? 193 ILE A H    1 
ATOM   3010 H HA   . ILE A 1 193 ? 12.76300  -17.15900 4.28000   1.000 21.70000  ? 193 ILE A HA   1 
ATOM   3011 H HB   . ILE A 1 193 ? 9.98100   -17.11900 3.65400   1.000 21.62000  ? 193 ILE A HB   1 
ATOM   3012 H HG12 . ILE A 1 193 ? 11.32100  -19.27400 4.82200   1.000 21.92000  ? 193 ILE A HG12 1 
ATOM   3013 H HG13 . ILE A 1 193 ? 10.66700  -18.13400 5.71500   1.000 21.92000  ? 193 ILE A HG13 1 
ATOM   3014 H HG21 . ILE A 1 193 ? 10.61700  -19.08900 2.27700   1.000 22.13000  ? 193 ILE A HG21 1 
ATOM   3015 H HG22 . ILE A 1 193 ? 10.84200  -17.65200 1.63700   1.000 22.13000  ? 193 ILE A HG22 1 
ATOM   3016 H HG23 . ILE A 1 193 ? 12.06700  -18.44000 2.27300   1.000 22.13000  ? 193 ILE A HG23 1 
ATOM   3017 H HD11 . ILE A 1 193 ? 9.12300   -19.73800 5.65800   1.000 22.23000  ? 193 ILE A HD11 1 
ATOM   3018 H HD12 . ILE A 1 193 ? 8.60100   -18.66400 4.61000   1.000 22.23000  ? 193 ILE A HD12 1 
ATOM   3019 H HD13 . ILE A 1 193 ? 9.33000   -19.98100 4.10100   1.000 22.23000  ? 193 ILE A HD13 1 
ATOM   3020 N N    . LYS A 1 194 ? 11.52600  -14.72200 2.58900   1.000 17.75000  ? 194 LYS A N    1 
ATOM   3021 C CA   . LYS A 1 194 ? 11.81100  -13.83100 1.47600   1.000 20.36000  ? 194 LYS A CA   1 
ATOM   3022 C C    . LYS A 1 194 ? 13.16200  -13.17100 1.64700   1.000 18.32000  ? 194 LYS A C    1 
ATOM   3023 O O    . LYS A 1 194 ? 13.92400  -13.05100 0.68300   1.000 20.06000  ? 194 LYS A O    1 
ATOM   3024 C CB   . LYS A 1 194 ? 10.71400  -12.75900 1.34000   1.000 25.32000  ? 194 LYS A CB   1 
ATOM   3025 C CG   . LYS A 1 194 ? 9.43000   -13.21300 0.74200   1.000 24.51000  ? 194 LYS A CG   1 
ATOM   3026 C CD   . LYS A 1 194 ? 8.38600   -12.06800 0.75700   1.000 28.85000  ? 194 LYS A CD   1 
ATOM   3027 C CE   . LYS A 1 194 ? 7.11300   -12.43800 0.01300   1.000 42.34000  ? 194 LYS A CE   1 
ATOM   3028 N NZ   . LYS A 1 194 ? 6.14100   -11.28500 0.04700   1.000 46.29000  ? 194 LYS A NZ   1 
ATOM   3029 H H    . LYS A 1 194 ? 10.80000  -14.54500 3.01300   1.000 21.32000  ? 194 LYS A H    1 
ATOM   3030 H HA   . LYS A 1 194 ? 11.81800  -14.35500 0.66000   1.000 24.45000  ? 194 LYS A HA   1 
ATOM   3031 H HB2  . LYS A 1 194 ? 10.51300  -12.41700 2.22400   1.000 30.40000  ? 194 LYS A HB2  1 
ATOM   3032 H HB3  . LYS A 1 194 ? 11.05500  -12.04600 0.77700   1.000 30.40000  ? 194 LYS A HB3  1 
ATOM   3033 H HG2  . LYS A 1 194 ? 9.57800   -13.48400 -0.17700  1.000 29.43000  ? 194 LYS A HG2  1 
ATOM   3034 H HG3  . LYS A 1 194 ? 9.07900   -13.95800 1.25500   1.000 29.43000  ? 194 LYS A HG3  1 
ATOM   3035 H HD2  . LYS A 1 194 ? 8.15100   -11.86500 1.67600   1.000 34.64000  ? 194 LYS A HD2  1 
ATOM   3036 H HD3  . LYS A 1 194 ? 8.76800   -11.28500 0.33100   1.000 34.64000  ? 194 LYS A HD3  1 
ATOM   3037 H HE2  . LYS A 1 194 ? 7.32200   -12.64100 -0.91200  1.000 50.83000  ? 194 LYS A HE2  1 
ATOM   3038 H HE3  . LYS A 1 194 ? 6.69900   -13.20600 0.43700   1.000 50.83000  ? 194 LYS A HE3  1 
ATOM   3039 H HZ1  . LYS A 1 194 ? 5.98700   -11.04100 0.88900   1.000 55.57000  ? 194 LYS A HZ1  1 
ATOM   3040 H HZ2  . LYS A 1 194 ? 5.37100   -11.52600 -0.32900  1.000 55.57000  ? 194 LYS A HZ2  1 
ATOM   3041 H HZ3  . LYS A 1 194 ? 6.47600   -10.59200 -0.39800  1.000 55.57000  ? 194 LYS A HZ3  1 
ATOM   3042 N N    . GLU A 1 195 ? 13.48400  -12.73500 2.86900   1.000 21.02000  ? 195 GLU A N    1 
ATOM   3043 C CA   . GLU A 1 195 ? 14.78400  -12.10700 3.12500   1.000 23.09000  ? 195 GLU A CA   1 
ATOM   3044 C C    . GLU A 1 195 ? 15.93300  -13.01600 2.75500   1.000 20.58000  ? 195 GLU A C    1 
ATOM   3045 O O    . GLU A 1 195 ? 16.90200  -12.60800 2.11600   1.000 21.76000  ? 195 GLU A O    1 
ATOM   3046 C CB   . GLU A 1 195 ? 14.92300  -11.71800 4.60300   1.000 27.03000  ? 195 GLU A CB   1 
ATOM   3047 C CG   . GLU A 1 195 ? 14.14900  -10.55400 5.13300   1.000 46.72000  ? 195 GLU A CG   1 
ATOM   3048 C CD   . GLU A 1 195 ? 14.15900  -10.52500 6.66800   1.000 41.35000  ? 195 GLU A CD   1 
ATOM   3049 O OE1  . GLU A 1 195 ? 15.02000  -11.21200 7.32000   1.000 32.22000  ? 195 GLU A OE1  1 
ATOM   3050 O OE2  . GLU A 1 195 ? 13.31800  -9.78300  7.22700   1.000 50.41000  ? 195 GLU A OE2  1 
ATOM   3051 H H    . GLU A 1 195 ? 12.97400  -12.79000 3.55900   1.000 25.25000  ? 195 GLU A H    1 
ATOM   3052 H HA   . GLU A 1 195 ? 14.82300  -11.30600 2.57900   1.000 27.73000  ? 195 GLU A HA   1 
ATOM   3053 H HB2  . GLU A 1 195 ? 14.65300  -12.48600 5.13100   1.000 32.46000  ? 195 GLU A HB2  1 
ATOM   3054 H HB3  . GLU A 1 195 ? 15.85800  -11.51700 4.76300   1.000 32.46000  ? 195 GLU A HB3  1 
ATOM   3055 H HG2  . GLU A 1 195 ? 14.54700  -9.73000  4.80900   1.000 56.09000  ? 195 GLU A HG2  1 
ATOM   3056 H HG3  . GLU A 1 195 ? 13.22900  -10.61700 4.83400   1.000 56.09000  ? 195 GLU A HG3  1 
ATOM   3057 N N    . VAL A 1 196 ? 15.84500  -14.26600 3.18800   1.000 19.26000  ? 196 VAL A N    1 
ATOM   3058 C CA   . VAL A 1 196 ? 16.93700  -15.20200 3.02800   1.000 17.00000  ? 196 VAL A CA   1 
ATOM   3059 C C    . VAL A 1 196 ? 17.09100  -15.57000 1.56400   1.000 18.58000  ? 196 VAL A C    1 
ATOM   3060 O O    . VAL A 1 196 ? 18.21400  -15.69100 1.06100   1.000 18.26000  ? 196 VAL A O    1 
ATOM   3061 C CB   . VAL A 1 196 ? 16.69100  -16.44600 3.91100   1.000 18.81000  ? 196 VAL A CB   1 
ATOM   3062 C CG1  . VAL A 1 196 ? 17.75200  -17.53600 3.65300   1.000 19.49000  ? 196 VAL A CG1  1 
ATOM   3063 C CG2  . VAL A 1 196 ? 16.69700  -16.07500 5.39200   1.000 20.48000  ? 196 VAL A CG2  1 
ATOM   3064 H H    . VAL A 1 196 ? 15.15600  -14.59800 3.58100   1.000 23.14000  ? 196 VAL A H    1 
ATOM   3065 H HA   . VAL A 1 196 ? 17.76300  -14.78600 3.31900   1.000 20.41000  ? 196 VAL A HA   1 
ATOM   3066 H HB   . VAL A 1 196 ? 15.81900  -16.80100 3.67900   1.000 22.59000  ? 196 VAL A HB   1 
ATOM   3067 H HG11 . VAL A 1 196 ? 17.67300  -18.22100 4.33500   1.000 23.41000  ? 196 VAL A HG11 1 
ATOM   3068 H HG12 . VAL A 1 196 ? 17.60100  -17.92300 2.77700   1.000 23.41000  ? 196 VAL A HG12 1 
ATOM   3069 H HG13 . VAL A 1 196 ? 18.63400  -17.13300 3.69000   1.000 23.41000  ? 196 VAL A HG13 1 
ATOM   3070 H HG21 . VAL A 1 196 ? 16.27100  -16.78600 5.89700   1.000 24.60000  ? 196 VAL A HG21 1 
ATOM   3071 H HG22 . VAL A 1 196 ? 17.61500  -15.96500 5.68700   1.000 24.60000  ? 196 VAL A HG22 1 
ATOM   3072 H HG23 . VAL A 1 196 ? 16.20900  -15.24600 5.51200   1.000 24.60000  ? 196 VAL A HG23 1 
ATOM   3073 N N    . VAL A 1 197 ? 15.96400  -15.80100 0.87500   1.000 19.82000  ? 197 VAL A N    1 
ATOM   3074 C CA   . VAL A 1 197 ? 16.00900  -16.13900 -0.54100  1.000 18.68000  ? 197 VAL A CA   1 
ATOM   3075 C C    . VAL A 1 197 ? 16.64200  -14.99400 -1.31600  1.000 19.66000  ? 197 VAL A C    1 
ATOM   3076 O O    . VAL A 1 197 ? 17.54500  -15.21000 -2.15900  1.000 20.78000  ? 197 VAL A O    1 
ATOM   3077 C CB   . VAL A 1 197 ? 14.60500  -16.49300 -1.05300  1.000 18.43000  ? 197 VAL A CB   1 
ATOM   3078 C CG1  . VAL A 1 197 ? 14.61700  -16.53300 -2.55600  1.000 22.92000  ? 197 VAL A CG1  1 
ATOM   3079 C CG2  . VAL A 1 197 ? 14.15300  -17.77100 -0.48900  1.000 19.64000  ? 197 VAL A CG2  1 
ATOM   3080 H H    . VAL A 1 197 ? 15.17100  -15.76800 1.20600   1.000 23.80000  ? 197 VAL A H    1 
ATOM   3081 H HA   . VAL A 1 197 ? 16.56200  -16.92500 -0.66900  1.000 22.43000  ? 197 VAL A HA   1 
ATOM   3082 H HB   . VAL A 1 197 ? 13.97200  -15.81600 -0.76800  1.000 22.13000  ? 197 VAL A HB   1 
ATOM   3083 H HG11 . VAL A 1 197 ? 13.87200  -17.07400 -2.86300  1.000 27.52000  ? 197 VAL A HG11 1 
ATOM   3084 H HG12 . VAL A 1 197 ? 14.53100  -15.62900 -2.89700  1.000 27.52000  ? 197 VAL A HG12 1 
ATOM   3085 H HG13 . VAL A 1 197 ? 15.45400  -16.92200 -2.85500  1.000 27.52000  ? 197 VAL A HG13 1 
ATOM   3086 H HG21 . VAL A 1 197 ? 13.19200  -17.84100 -0.59500  1.000 23.58000  ? 197 VAL A HG21 1 
ATOM   3087 H HG22 . VAL A 1 197 ? 14.59200  -18.49700 -0.96100  1.000 23.58000  ? 197 VAL A HG22 1 
ATOM   3088 H HG23 . VAL A 1 197 ? 14.38600  -17.80000 0.45200   1.000 23.58000  ? 197 VAL A HG23 1 
ATOM   3089 N N    . LYS A 1 198 ? 16.17800  -13.74300 -1.03400  1.000 21.19000  ? 198 LYS A N    1 
ATOM   3090 C CA   . LYS A 1 198 ? 16.67500  -12.62500 -1.82000  1.000 23.07000  ? 198 LYS A CA   1 
ATOM   3091 C C    . LYS A 1 198 ? 18.15700  -12.37100 -1.55400  1.000 20.74000  ? 198 LYS A C    1 
ATOM   3092 O O    . LYS A 1 198 ? 18.90100  -12.00600 -2.48300  1.000 23.81000  ? 198 LYS A O    1 
ATOM   3093 C CB   . LYS A 1 198 ? 15.83500  -11.39500 -1.51500  1.000 20.59000  ? 198 LYS A CB   1 
ATOM   3094 C CG   . LYS A 1 198 ? 14.47000  -11.40200 -2.14600  1.000 26.09000  ? 198 LYS A CG   1 
ATOM   3095 C CD   . LYS A 1 198 ? 13.60900  -10.38000 -1.41700  1.000 34.28000  ? 198 LYS A CD   1 
ATOM   3096 C CE   . LYS A 1 198 ? 12.15900  -10.42900 -1.80300  1.000 49.65000  ? 198 LYS A CE   1 
ATOM   3097 N NZ   . LYS A 1 198 ? 11.86000  -9.58700  -2.95600  1.000 54.89000  ? 198 LYS A NZ   1 
ATOM   3098 H H    . LYS A 1 198 ? 15.60700  -13.54500 -0.42200  1.000 25.44000  ? 198 LYS A H    1 
ATOM   3099 H HA   . LYS A 1 198 ? 16.58800  -12.82000 -2.76700  1.000 27.71000  ? 198 LYS A HA   1 
ATOM   3100 H HB2  . LYS A 1 198 ? 15.71400  -11.33400 -0.55500  1.000 24.73000  ? 198 LYS A HB2  1 
ATOM   3101 H HB3  . LYS A 1 198 ? 16.30400  -10.61100 -1.84100  1.000 24.73000  ? 198 LYS A HB3  1 
ATOM   3102 H HG2  . LYS A 1 198 ? 14.53300  -11.15800 -3.08200  1.000 31.32000  ? 198 LYS A HG2  1 
ATOM   3103 H HG3  . LYS A 1 198 ? 14.06600  -12.28000 -2.05800  1.000 31.32000  ? 198 LYS A HG3  1 
ATOM   3104 H HD2  . LYS A 1 198 ? 13.66700  -10.54400 -0.46300  1.000 41.16000  ? 198 LYS A HD2  1 
ATOM   3105 H HD3  . LYS A 1 198 ? 13.93900  -9.49100  -1.62200  1.000 41.16000  ? 198 LYS A HD3  1 
ATOM   3106 H HE2  . LYS A 1 198 ? 11.92100  -11.34300 -2.02700  1.000 59.60000  ? 198 LYS A HE2  1 
ATOM   3107 H HE3  . LYS A 1 198 ? 11.62100  -10.12000 -1.05700  1.000 59.60000  ? 198 LYS A HE3  1 
ATOM   3108 H HZ1  . LYS A 1 198 ? 11.03100  -9.74400  -3.24100  1.000 65.89000  ? 198 LYS A HZ1  1 
ATOM   3109 H HZ2  . LYS A 1 198 ? 11.93000  -8.72900  -2.73200  1.000 65.89000  ? 198 LYS A HZ2  1 
ATOM   3110 H HZ3  . LYS A 1 198 ? 12.43000  -9.76200  -3.61600  1.000 65.89000  ? 198 LYS A HZ3  1 
ATOM   3111 N N    . LYS A 1 199 ? 18.63000  -12.61300 -0.33500  1.000 21.97000  ? 199 LYS A N    1 
ATOM   3112 C CA   . LYS A 1 199 ? 20.02100  -12.35700 -0.00600  1.000 21.22000  ? 199 LYS A CA   1 
ATOM   3113 C C    . LYS A 1 199 ? 20.95100  -13.39300 -0.62700  1.000 23.56000  ? 199 LYS A C    1 
ATOM   3114 O O    . LYS A 1 199 ? 22.02400  -13.04700 -1.15200  1.000 24.18000  ? 199 LYS A O    1 
ATOM   3115 C CB   . LYS A 1 199 ? 20.19300  -12.31000 1.50000   1.000 26.00000  ? 199 LYS A CB   1 
ATOM   3116 C CG   . LYS A 1 199 ? 21.63800  -12.27400 1.99800   1.000 25.51000  ? 199 LYS A CG   1 
ATOM   3117 C CD   . LYS A 1 199 ? 21.64300  -12.20000 3.53800   1.000 32.77000  ? 199 LYS A CD   1 
ATOM   3118 C CE   . LYS A 1 199 ? 23.01100  -11.90300 4.11900   1.000 42.36000  ? 199 LYS A CE   1 
ATOM   3119 N NZ   . LYS A 1 199 ? 23.03000  -12.20700 5.60100   1.000 63.47000  ? 199 LYS A NZ   1 
ATOM   3120 H H    . LYS A 1 199 ? 18.16500  -12.92600 0.31700   1.000 26.38000  ? 199 LYS A H    1 
ATOM   3121 H HA   . LYS A 1 199 ? 20.26900  -11.49200 -0.36800  1.000 25.48000  ? 199 LYS A HA   1 
ATOM   3122 H HB2  . LYS A 1 199 ? 19.75400  -11.51200 1.83200   1.000 31.22000  ? 199 LYS A HB2  1 
ATOM   3123 H HB3  . LYS A 1 199 ? 19.77700  -13.10000 1.87900   1.000 31.22000  ? 199 LYS A HB3  1 
ATOM   3124 H HG2  . LYS A 1 199 ? 22.10300  -13.07900 1.72000   1.000 30.63000  ? 199 LYS A HG2  1 
ATOM   3125 H HG3  . LYS A 1 199 ? 22.09000  -11.49200 1.64400   1.000 30.63000  ? 199 LYS A HG3  1 
ATOM   3126 H HD2  . LYS A 1 199 ? 21.04000  -11.49400 3.82000   1.000 39.34000  ? 199 LYS A HD2  1 
ATOM   3127 H HD3  . LYS A 1 199 ? 21.34600  -13.05200 3.89500   1.000 39.34000  ? 199 LYS A HD3  1 
ATOM   3128 H HE2  . LYS A 1 199 ? 23.67700  -12.45600 3.68100   1.000 50.85000  ? 199 LYS A HE2  1 
ATOM   3129 H HE3  . LYS A 1 199 ? 23.22200  -10.96500 3.99200   1.000 50.85000  ? 199 LYS A HE3  1 
ATOM   3130 H HZ1  . LYS A 1 199 ? 22.47100  -11.66400 6.03000   1.000 76.18000  ? 199 LYS A HZ1  1 
ATOM   3131 H HZ2  . LYS A 1 199 ? 22.78000  -13.04900 5.74200   1.000 76.18000  ? 199 LYS A HZ2  1 
ATOM   3132 H HZ3  . LYS A 1 199 ? 23.85100  -12.09100 5.92500   1.000 76.18000  ? 199 LYS A HZ3  1 
ATOM   3133 N N    . HIS A 1 200 ? 20.61100  -14.67700 -0.51900  1.000 20.06000  ? 200 HIS A N    1 
ATOM   3134 C CA   . HIS A 1 200 ? 21.53600  -15.75600 -0.84800  1.000 20.64000  ? 200 HIS A CA   1 
ATOM   3135 C C    . HIS A 1 200 ? 21.24800  -16.49800 -2.13400  1.000 20.81000  ? 200 HIS A C    1 
ATOM   3136 O O    . HIS A 1 200 ? 22.12400  -17.27300 -2.57500  1.000 24.38000  ? 200 HIS A O    1 
ATOM   3137 C CB   . HIS A 1 200 ? 21.52000  -16.72800 0.29700   1.000 23.82000  ? 200 HIS A CB   1 
ATOM   3138 C CG   . HIS A 1 200 ? 22.09000  -16.24500 1.58200   1.000 23.23000  ? 200 HIS A CG   1 
ATOM   3139 N ND1  . HIS A 1 200 ? 23.38400  -15.78700 1.71300   1.000 28.33000  ? 200 HIS A ND1  1 
ATOM   3140 C CD2  . HIS A 1 200 ? 21.47900  -15.95000 2.75500   1.000 25.28000  ? 200 HIS A CD2  1 
ATOM   3141 C CE1  . HIS A 1 200 ? 23.58800  -15.39700 2.95600   1.000 28.12000  ? 200 HIS A CE1  1 
ATOM   3142 N NE2  . HIS A 1 200 ? 22.44900  -15.49200 3.60900   1.000 29.68000  ? 200 HIS A NE2  1 
ATOM   3143 H H    . HIS A 1 200 ? 19.84000  -14.95000 -0.25300  1.000 24.10000  ? 200 HIS A H    1 
ATOM   3144 H HA   . HIS A 1 200 ? 22.42400  -15.38200 -0.96600  1.000 24.78000  ? 200 HIS A HA   1 
ATOM   3145 H HB2  . HIS A 1 200 ? 20.59800  -16.97600 0.46900   1.000 28.60000  ? 200 HIS A HB2  1 
ATOM   3146 H HB3  . HIS A 1 200 ? 22.03000  -17.51100 0.03500   1.000 28.60000  ? 200 HIS A HB3  1 
ATOM   3147 H HD1  . HIS A 1 200 ? 23.96700  -15.75900 1.08200   1.000 34.01000  ? 200 HIS A HD1  1 
ATOM   3148 H HD2  . HIS A 1 200 ? 20.57300  -16.04100 2.94500   1.000 30.36000  ? 200 HIS A HD2  1 
ATOM   3149 H HE1  . HIS A 1 200 ? 24.39700  -15.10600 3.31100   1.000 33.76000  ? 200 HIS A HE1  1 
ATOM   3150 H HE2  . HIS A 1 200 ? 22.33100  -15.29600 4.43800   1.000 35.64000  ? 200 HIS A HE2  1 
ATOM   3151 N N    . SER A 1 201 ? 20.07800  -16.33800 -2.72500  1.000 21.50000  ? 201 SER A N    1 
ATOM   3152 C CA   . SER A 1 201 ? 19.65100  -17.13100 -3.87600  1.000 18.69000  ? 201 SER A CA   1 
ATOM   3153 C C    . SER A 1 201 ? 19.13500  -16.23800 -5.01500  1.000 18.04000  ? 201 SER A C    1 
ATOM   3154 O O    . SER A 1 201 ? 18.23500  -16.59800 -5.76800  1.000 25.84000  ? 201 SER A O    1 
ATOM   3155 C CB   . SER A 1 201 ? 18.58900  -18.17600 -3.44900  1.000 20.22000  ? 201 SER A CB   1 
ATOM   3156 O OG   . SER A 1 201 ? 19.09400  -19.04600 -2.43600  1.000 21.25000  ? 201 SER A OG   1 
ATOM   3157 H H    . SER A 1 201 ? 19.49200  -15.76100 -2.47400  1.000 25.82000  ? 201 SER A H    1 
ATOM   3158 H HA   . SER A 1 201 ? 20.42100  -17.60600 -4.22700  1.000 22.45000  ? 201 SER A HA   1 
ATOM   3159 H HB2  . SER A 1 201 ? 17.81200  -17.71000 -3.10300  1.000 24.28000  ? 201 SER A HB2  1 
ATOM   3160 H HB3  . SER A 1 201 ? 18.34100  -18.70600 -4.22300  1.000 24.28000  ? 201 SER A HB3  1 
ATOM   3161 H HG   . SER A 1 201 ? 19.91200  -19.19000 -2.56200  1.000 25.52000  ? 201 SER A HG   1 
ATOM   3162 N N    . GLU A 1 202 ? 19.87500  -15.12700 -5.28300  1.000 22.22000  ? 202 GLU A N    1 
ATOM   3163 C CA   . GLU A 1 202 ? 19.48800  -14.20800 -6.34500  1.000 23.17000  ? 202 GLU A CA   1 
ATOM   3164 C C    . GLU A 1 202 ? 19.67500  -14.83700 -7.72700  1.000 24.88000  ? 202 GLU A C    1 
ATOM   3165 O O    . GLU A 1 202 ? 18.90400  -14.60400 -8.66300  1.000 30.15000  ? 202 GLU A O    1 
ATOM   3166 C CB   . GLU A 1 202 ? 20.33600  -12.94500 -6.23100  1.000 24.69000  ? 202 GLU A CB   1 
ATOM   3167 C CG   . GLU A 1 202 ? 20.22800  -12.08500 -7.52500  1.000 29.96000  ? 202 GLU A CG   1 
ATOM   3168 C CD   . GLU A 1 202 ? 20.71700  -10.66900 -7.42100  1.000 41.26000  ? 202 GLU A CD   1 
ATOM   3169 O OE1  . GLU A 1 202 ? 21.36100  -10.32700 -6.43500  1.000 35.99000  ? 202 GLU A OE1  1 
ATOM   3170 O OE2  . GLU A 1 202 ? 20.49400  -9.90900  -8.39000  1.000 40.73000  ? 202 GLU A OE2  1 
ATOM   3171 H H    . GLU A 1 202 ? 20.59000  -14.90100 -4.86300  1.000 26.68000  ? 202 GLU A H    1 
ATOM   3172 H HA   . GLU A 1 202 ? 18.55000  -13.98000 -6.24600  1.000 27.83000  ? 202 GLU A HA   1 
ATOM   3173 H HB2  . GLU A 1 202 ? 20.02600  -12.41400 -5.48100  1.000 29.65000  ? 202 GLU A HB2  1 
ATOM   3174 H HB3  . GLU A 1 202 ? 21.26600  -13.19100 -6.10200  1.000 29.65000  ? 202 GLU A HB3  1 
ATOM   3175 H HG2  . GLU A 1 202 ? 20.74800  -12.51600 -8.22000  1.000 35.97000  ? 202 GLU A HG2  1 
ATOM   3176 H HG3  . GLU A 1 202 ? 19.29400  -12.04600 -7.78500  1.000 35.97000  ? 202 GLU A HG3  1 
ATOM   3177 N N    . PHE A 1 203 ? 20.70200  -15.62700 -7.90400  1.000 20.67000  ? 203 PHE A N    1 
ATOM   3178 C CA   . PHE A 1 203 ? 21.04400  -16.14100 -9.21000  1.000 20.49000  ? 203 PHE A CA   1 
ATOM   3179 C C    . PHE A 1 203 ? 20.67100  -17.60200 -9.30700  1.000 17.60000  ? 203 PHE A C    1 
ATOM   3180 O O    . PHE A 1 203 ? 21.52300  -18.48600 -9.36400  1.000 19.93000  ? 203 PHE A O    1 
ATOM   3181 C CB   . PHE A 1 203 ? 22.50300  -15.93600 -9.47400  1.000 21.22000  ? 203 PHE A CB   1 
ATOM   3182 C CG   . PHE A 1 203 ? 22.90400  -14.46200 -9.44100  1.000 23.17000  ? 203 PHE A CG   1 
ATOM   3183 C CD1  . PHE A 1 203 ? 22.58300  -13.65300 -10.48800 1.000 26.82000  ? 203 PHE A CD1  1 
ATOM   3184 C CD2  . PHE A 1 203 ? 23.48600  -13.93500 -8.32200  1.000 26.75000  ? 203 PHE A CD2  1 
ATOM   3185 C CE1  . PHE A 1 203 ? 22.93800  -12.27600 -10.44700 1.000 27.84000  ? 203 PHE A CE1  1 
ATOM   3186 C CE2  . PHE A 1 203 ? 23.81500  -12.56700 -8.29200  1.000 28.85000  ? 203 PHE A CE2  1 
ATOM   3187 C CZ   . PHE A 1 203 ? 23.51100  -11.81700 -9.32600  1.000 25.21000  ? 203 PHE A CZ   1 
ATOM   3188 H H    . PHE A 1 203 ? 21.22700  -15.88700 -7.27400  1.000 24.82000  ? 203 PHE A H    1 
ATOM   3189 H HA   . PHE A 1 203 ? 20.51600  -15.66400 -9.87000  1.000 24.61000  ? 203 PHE A HA   1 
ATOM   3190 H HB2  . PHE A 1 203 ? 23.01500  -16.40300 -8.79500  1.000 25.48000  ? 203 PHE A HB2  1 
ATOM   3191 H HB3  . PHE A 1 203 ? 22.71800  -16.28800 -10.35200 1.000 25.48000  ? 203 PHE A HB3  1 
ATOM   3192 H HD1  . PHE A 1 203 ? 22.13400  -13.99800 -11.22600 1.000 32.21000  ? 203 PHE A HD1  1 
ATOM   3193 H HD2  . PHE A 1 203 ? 23.66400  -14.47700 -7.58700  1.000 32.12000  ? 203 PHE A HD2  1 
ATOM   3194 H HE1  . PHE A 1 203 ? 22.78000  -11.71500 -11.17200 1.000 33.43000  ? 203 PHE A HE1  1 
ATOM   3195 H HE2  . PHE A 1 203 ? 24.24100  -12.20000 -7.55100  1.000 34.64000  ? 203 PHE A HE2  1 
ATOM   3196 H HZ   . PHE A 1 203 ? 23.70500  -10.90900 -9.27600  1.000 30.28000  ? 203 PHE A HZ   1 
ATOM   3197 N N    . VAL A 1 204 ? 19.35800  -17.82900 -9.47100  1.000 19.21000  ? 204 VAL A N    1 
ATOM   3198 C CA   . VAL A 1 204 ? 18.78100  -19.14900 -9.69800  1.000 15.74000  ? 204 VAL A CA   1 
ATOM   3199 C C    . VAL A 1 204 ? 17.91000  -19.09000 -10.93700 1.000 18.61000  ? 204 VAL A C    1 
ATOM   3200 O O    . VAL A 1 204 ? 17.18300  -18.10900 -11.15500 1.000 21.65000  ? 204 VAL A O    1 
ATOM   3201 C CB   . VAL A 1 204 ? 17.95800  -19.57500 -8.42600  1.000 19.04000  ? 204 VAL A CB   1 
ATOM   3202 C CG1  . VAL A 1 204 ? 17.29600  -20.89900 -8.58400  1.000 20.86000  ? 204 VAL A CG1  1 
ATOM   3203 C CG2  . VAL A 1 204 ? 18.87500  -19.56900 -7.22800  1.000 20.43000  ? 204 VAL A CG2  1 
ATOM   3204 H H    . VAL A 1 204 ? 18.76600  -17.20500 -9.45400  1.000 23.07000  ? 204 VAL A H    1 
ATOM   3205 H HA   . VAL A 1 204 ? 19.46800  -19.81100 -9.87200  1.000 18.91000  ? 204 VAL A HA   1 
ATOM   3206 H HB   . VAL A 1 204 ? 17.24000  -18.93600 -8.29400  1.000 22.87000  ? 204 VAL A HB   1 
ATOM   3207 H HG11 . VAL A 1 204 ? 17.30200  -21.35900 -7.73000  1.000 25.05000  ? 204 VAL A HG11 1 
ATOM   3208 H HG12 . VAL A 1 204 ? 16.38200  -20.76100 -8.87900  1.000 25.05000  ? 204 VAL A HG12 1 
ATOM   3209 H HG13 . VAL A 1 204 ? 17.78200  -21.41800 -9.24400  1.000 25.05000  ? 204 VAL A HG13 1 
ATOM   3210 H HG21 . VAL A 1 204 ? 18.37200  -19.83700 -6.44300  1.000 24.54000  ? 204 VAL A HG21 1 
ATOM   3211 H HG22 . VAL A 1 204 ? 19.60200  -20.19300 -7.38300  1.000 24.54000  ? 204 VAL A HG22 1 
ATOM   3212 H HG23 . VAL A 1 204 ? 19.22800  -18.67400 -7.10500  1.000 24.54000  ? 204 VAL A HG23 1 
ATOM   3213 N N    . ALA A 1 205 ? 18.04100  -20.09400 -11.80300 1.000 15.94000  ? 205 ALA A N    1 
ATOM   3214 C CA   . ALA A 1 205 ? 17.41000  -20.08700 -13.13800 1.000 16.52000  ? 205 ALA A CA   1 
ATOM   3215 C C    . ALA A 1 205 ? 15.95300  -20.50700 -13.10900 1.000 20.42000  ? 205 ALA A C    1 
ATOM   3216 O O    . ALA A 1 205 ? 15.32400  -20.45400 -14.16500 1.000 25.79000  ? 205 ALA A O    1 
ATOM   3217 C CB   . ALA A 1 205 ? 18.18200  -21.04100 -14.00000 1.000 19.51000  ? 205 ALA A CB   1 
ATOM   3218 H H    . ALA A 1 205 ? 18.48200  -20.85800 -11.62000 1.000 19.14000  ? 205 ALA A H    1 
ATOM   3219 H HA   . ALA A 1 205 ? 17.47100  -19.17000 -13.51900 1.000 19.85000  ? 205 ALA A HA   1 
ATOM   3220 H HB1  . ALA A 1 205 ? 17.97900  -20.87700 -14.93500 1.000 23.43000  ? 205 ALA A HB1  1 
ATOM   3221 H HB2  . ALA A 1 205 ? 19.13400  -20.91800 -13.85000 1.000 23.43000  ? 205 ALA A HB2  1 
ATOM   3222 H HB3  . ALA A 1 205 ? 17.93700  -21.95500 -13.77200 1.000 23.43000  ? 205 ALA A HB3  1 
ATOM   3223 N N    . TYR A 1 206 ? 15.47600  -20.92900 -11.95000 1.000 17.19000  ? 206 TYR A N    1 
ATOM   3224 C CA   . TYR A 1 206 ? 14.09600  -21.44500 -11.83600 1.000 19.35000  ? 206 TYR A CA   1 
ATOM   3225 C C    . TYR A 1 206 ? 13.32200  -20.57700 -10.91400 1.000 17.09000  ? 206 TYR A C    1 
ATOM   3226 O O    . TYR A 1 206 ? 13.88800  -19.98100 -10.01700 1.000 18.29000  ? 206 TYR A O    1 
ATOM   3227 C CB   . TYR A 1 206 ? 14.14700  -22.87400 -11.31400 1.000 17.83000  ? 206 TYR A CB   1 
ATOM   3228 C CG   . TYR A 1 206 ? 15.11800  -23.72700 -12.10300 1.000 17.00000  ? 206 TYR A CG   1 
ATOM   3229 C CD1  . TYR A 1 206 ? 14.74400  -24.29200 -13.31000 1.000 17.63000  ? 206 TYR A CD1  1 
ATOM   3230 C CD2  . TYR A 1 206 ? 16.41000  -23.93100 -11.64700 1.000 15.76000  ? 206 TYR A CD2  1 
ATOM   3231 C CE1  . TYR A 1 206 ? 15.63000  -25.05300 -14.04600 1.000 17.46000  ? 206 TYR A CE1  1 
ATOM   3232 C CE2  . TYR A 1 206 ? 17.30300  -24.69500 -12.36800 1.000 16.01000  ? 206 TYR A CE2  1 
ATOM   3233 C CZ   . TYR A 1 206 ? 16.90900  -25.24700 -13.56800 1.000 19.47000  ? 206 TYR A CZ   1 
ATOM   3234 O OH   . TYR A 1 206 ? 17.79500  -26.00600 -14.23700 1.000 21.80000  ? 206 TYR A OH   1 
ATOM   3235 H H    . TYR A 1 206 ? 15.97300  -20.93900 -11.19900 1.000 20.65000  ? 206 TYR A H    1 
ATOM   3236 H HA   . TYR A 1 206 ? 13.67200  -21.44600 -12.72600 1.000 23.24000  ? 206 TYR A HA   1 
ATOM   3237 H HB2  . TYR A 1 206 ? 14.42300  -22.85800 -10.37100 1.000 21.42000  ? 206 TYR A HB2  1 
ATOM   3238 H HB3  . TYR A 1 206 ? 13.24800  -23.26800 -11.37300 1.000 21.42000  ? 206 TYR A HB3  1 
ATOM   3239 H HD1  . TYR A 1 206 ? 13.86900  -24.15400 -13.63700 1.000 21.17000  ? 206 TYR A HD1  1 
ATOM   3240 H HD2  . TYR A 1 206 ? 16.68100  -23.54700 -10.82800 1.000 18.93000  ? 206 TYR A HD2  1 
ATOM   3241 H HE1  . TYR A 1 206 ? 15.36200  -25.44500 -14.86000 1.000 20.97000  ? 206 TYR A HE1  1 
ATOM   3242 H HE2  . TYR A 1 206 ? 18.17600  -24.83700 -12.04600 1.000 19.23000  ? 206 TYR A HE2  1 
ATOM   3243 H HH   . TYR A 1 206 ? 18.57100  -25.65300 -14.18500 1.000 26.18000  ? 206 TYR A HH   1 
ATOM   3244 N N    . PRO A 1 207 ? 12.00000  -20.49100 -11.11400 1.000 16.90000  ? 207 PRO A N    1 
ATOM   3245 C CA   . PRO A 1 207 ? 11.14600  -19.73000 -10.21000 1.000 18.00000  ? 207 PRO A CA   1 
ATOM   3246 C C    . PRO A 1 207 ? 11.20800  -20.31000 -8.80900  1.000 15.41000  ? 207 PRO A C    1 
ATOM   3247 O O    . PRO A 1 207 ? 11.14300  -21.52500 -8.72400  1.000 16.98000  ? 207 PRO A O    1 
ATOM   3248 C CB   . PRO A 1 207 ? 9.75600   -19.87800 -10.80800 1.000 21.59000  ? 207 PRO A CB   1 
ATOM   3249 C CG   . PRO A 1 207 ? 9.82400   -21.13900 -11.62800 1.000 21.57000  ? 207 PRO A CG   1 
ATOM   3250 C CD   . PRO A 1 207 ? 11.19000  -21.11800 -12.20200 1.000 19.17000  ? 207 PRO A CD   1 
ATOM   3251 H HA   . PRO A 1 207 ? 11.42000  -18.79100 -10.20000 1.000 21.62000  ? 207 PRO A HA   1 
ATOM   3252 H HB2  . PRO A 1 207 ? 9.08400   -19.95900 -10.10300 1.000 25.93000  ? 207 PRO A HB2  1 
ATOM   3253 H HB3  . PRO A 1 207 ? 9.53600   -19.11000 -11.36900 1.000 25.93000  ? 207 PRO A HB3  1 
ATOM   3254 H HG2  . PRO A 1 207 ? 9.69600   -21.93100 -11.06800 1.000 25.90000  ? 207 PRO A HG2  1 
ATOM   3255 H HG3  . PRO A 1 207 ? 9.15000   -21.13400 -12.33300 1.000 25.90000  ? 207 PRO A HG3  1 
ATOM   3256 H HD2  . PRO A 1 207 ? 11.50500  -22.01900 -12.39600 1.000 23.02000  ? 207 PRO A HD2  1 
ATOM   3257 H HD3  . PRO A 1 207 ? 11.22700  -20.58000 -13.01500 1.000 23.02000  ? 207 PRO A HD3  1 
ATOM   3258 N N    . ILE A 1 208 ? 11.36200  -19.48900 -7.78600  1.000 15.98000  ? 208 ILE A N    1 
ATOM   3259 C CA   . ILE A 1 208 ? 11.29700  -19.87200 -6.36800  1.000 15.22000  ? 208 ILE A CA   1 
ATOM   3260 C C    . ILE A 1 208 ? 9.94700   -19.38500 -5.85200  1.000 18.02000  ? 208 ILE A C    1 
ATOM   3261 O O    . ILE A 1 208 ? 9.72000   -18.17200 -5.73300  1.000 19.00000  ? 208 ILE A O    1 
ATOM   3262 C CB   . ILE A 1 208 ? 12.46700  -19.30500 -5.54800  1.000 15.69000  ? 208 ILE A CB   1 
ATOM   3263 C CG1  . ILE A 1 208 ? 13.77200  -19.85200 -6.12200  1.000 17.22000  ? 208 ILE A CG1  1 
ATOM   3264 C CG2  . ILE A 1 208 ? 12.31900  -19.70100 -4.04700  1.000 17.87000  ? 208 ILE A CG2  1 
ATOM   3265 C CD1  . ILE A 1 208 ? 15.03300  -19.18800 -5.56300  1.000 20.76000  ? 208 ILE A CD1  1 
ATOM   3266 H H    . ILE A 1 208 ? 11.48300  -18.64500 -7.90100  1.000 19.20000  ? 208 ILE A H    1 
ATOM   3267 H HA   . ILE A 1 208 ? 11.33500  -20.83800 -6.28500  1.000 18.28000  ? 208 ILE A HA   1 
ATOM   3268 H HB   . ILE A 1 208 ? 12.46800  -18.33600 -5.60300  1.000 18.85000  ? 208 ILE A HB   1 
ATOM   3269 H HG12 . ILE A 1 208 ? 13.82500  -20.80000 -5.92200  1.000 20.68000  ? 208 ILE A HG12 1 
ATOM   3270 H HG13 . ILE A 1 208 ? 13.76900  -19.71500 -7.08300  1.000 20.68000  ? 208 ILE A HG13 1 
ATOM   3271 H HG21 . ILE A 1 208 ? 13.14800  -19.50400 -3.58400  1.000 21.46000  ? 208 ILE A HG21 1 
ATOM   3272 H HG22 . ILE A 1 208 ? 11.59200  -19.19100 -3.65600  1.000 21.46000  ? 208 ILE A HG22 1 
ATOM   3273 H HG23 . ILE A 1 208 ? 12.12500  -20.65000 -3.98800  1.000 21.46000  ? 208 ILE A HG23 1 
ATOM   3274 H HD11 . ILE A 1 208 ? 15.68400  -19.09600 -6.27600  1.000 24.94000  ? 208 ILE A HD11 1 
ATOM   3275 H HD12 . ILE A 1 208 ? 14.80100  -18.31400 -5.21200  1.000 24.94000  ? 208 ILE A HD12 1 
ATOM   3276 H HD13 . ILE A 1 208 ? 15.39400  -19.74300 -4.85400  1.000 24.94000  ? 208 ILE A HD13 1 
ATOM   3277 N N    . GLN A 1 209 ? 9.01800   -20.33400 -5.66400  1.000 15.26000  ? 209 GLN A N    1 
ATOM   3278 C CA   . GLN A 1 209 ? 7.63000   -20.03700 -5.27200  1.000 16.15000  ? 209 GLN A CA   1 
ATOM   3279 C C    . GLN A 1 209 ? 7.48900   -20.20600 -3.75700  1.000 18.76000  ? 209 GLN A C    1 
ATOM   3280 O O    . GLN A 1 209 ? 8.11100   -21.07900 -3.15700  1.000 21.76000  ? 209 GLN A O    1 
ATOM   3281 C CB   . GLN A 1 209 ? 6.69200   -21.00500 -5.95200  1.000 16.87000  ? 209 GLN A CB   1 
ATOM   3282 C CG   . GLN A 1 209 ? 6.67800   -20.84100 -7.43300  1.000 18.48000  ? 209 GLN A CG   1 
ATOM   3283 C CD   . GLN A 1 209 ? 6.11100   -22.03200 -8.17800  1.000 20.27000  ? 209 GLN A CD   1 
ATOM   3284 O OE1  . GLN A 1 209 ? 5.76800   -23.07300 -7.60300  1.000 21.82000  ? 209 GLN A OE1  1 
ATOM   3285 N NE2  . GLN A 1 209 ? 5.98100   -21.86500 -9.48200  1.000 27.44000  ? 209 GLN A NE2  1 
ATOM   3286 H H    . GLN A 1 209 ? 9.17100   -21.17500 -5.75900  1.000 18.34000  ? 209 GLN A H    1 
ATOM   3287 H HA   . GLN A 1 209 ? 7.39600   -19.12800 -5.52000  1.000 19.40000  ? 209 GLN A HA   1 
ATOM   3288 H HB2  . GLN A 1 209 ? 6.97300   -21.91200 -5.75200  1.000 20.26000  ? 209 GLN A HB2  1 
ATOM   3289 H HB3  . GLN A 1 209 ? 5.79100   -20.85700 -5.62400  1.000 20.26000  ? 209 GLN A HB3  1 
ATOM   3290 H HG2  . GLN A 1 209 ? 6.13600   -20.06800 -7.65600  1.000 22.19000  ? 209 GLN A HG2  1 
ATOM   3291 H HG3  . GLN A 1 209 ? 7.58800   -20.70800 -7.74000  1.000 22.19000  ? 209 GLN A HG3  1 
ATOM   3292 H HE21 . GLN A 1 209 ? 6.21300   -21.12100 -9.84500  1.000 32.94000  ? 209 GLN A HE21 1 
ATOM   3293 H HE22 . GLN A 1 209 ? 5.66600   -22.50100 -9.96700  1.000 32.94000  ? 209 GLN A HE22 1 
ATOM   3294 N N    . LEU A 1 210 ? 6.77000   -19.28400 -3.11500  1.000 16.27000  ? 210 LEU A N    1 
ATOM   3295 C CA   . LEU A 1 210 ? 6.53700   -19.32000 -1.68900  1.000 14.94000  ? 210 LEU A CA   1 
ATOM   3296 C C    . LEU A 1 210 ? 5.04000   -19.45800 -1.46600  1.000 15.20000  ? 210 LEU A C    1 
ATOM   3297 O O    . LEU A 1 210 ? 4.25900   -18.66700 -2.01000  1.000 17.30000  ? 210 LEU A O    1 
ATOM   3298 C CB   . LEU A 1 210 ? 7.06300   -18.05800 -1.01300  1.000 17.84000  ? 210 LEU A CB   1 
ATOM   3299 C CG   . LEU A 1 210 ? 6.87100   -17.94900 0.45700   1.000 20.57000  ? 210 LEU A CG   1 
ATOM   3300 C CD1  . LEU A 1 210 ? 7.41800   -19.08300 1.27200   1.000 20.65000  ? 210 LEU A CD1  1 
ATOM   3301 C CD2  . LEU A 1 210 ? 7.54500   -16.63200 0.93400   1.000 22.70000  ? 210 LEU A CD2  1 
ATOM   3302 H H    . LEU A 1 210 ? 6.40000   -18.61300 -3.50400  1.000 19.54000  ? 210 LEU A H    1 
ATOM   3303 H HA   . LEU A 1 210 ? 6.99100   -20.07800 -1.28900  1.000 17.94000  ? 210 LEU A HA   1 
ATOM   3304 H HB2  . LEU A 1 210 ? 8.01700   -18.00700 -1.17800  1.000 21.43000  ? 210 LEU A HB2  1 
ATOM   3305 H HB3  . LEU A 1 210 ? 6.61500   -17.29700 -1.41400  1.000 21.43000  ? 210 LEU A HB3  1 
ATOM   3306 H HG   . LEU A 1 210 ? 5.91300   -17.96700 0.61100   1.000 24.70000  ? 210 LEU A HG   1 
ATOM   3307 H HD11 . LEU A 1 210 ? 7.58800   -18.77100 2.17400   1.000 24.79000  ? 210 LEU A HD11 1 
ATOM   3308 H HD12 . LEU A 1 210 ? 6.76700   -19.80300 1.28900   1.000 24.79000  ? 210 LEU A HD12 1 
ATOM   3309 H HD13 . LEU A 1 210 ? 8.24300   -19.39300 0.86800   1.000 24.79000  ? 210 LEU A HD13 1 
ATOM   3310 H HD21 . LEU A 1 210 ? 7.40200   -16.53200 1.88800   1.000 27.26000  ? 210 LEU A HD21 1 
ATOM   3311 H HD22 . LEU A 1 210 ? 8.49500   -16.67700 0.74500   1.000 27.26000  ? 210 LEU A HD22 1 
ATOM   3312 H HD23 . LEU A 1 210 ? 7.14800   -15.88500 0.46000   1.000 27.26000  ? 210 LEU A HD23 1 
ATOM   3313 N N    . VAL A 1 211 ? 4.65800   -20.43400 -0.68400  1.000 15.17000  ? 211 VAL A N    1 
ATOM   3314 C CA   . VAL A 1 211 ? 3.26600   -20.75300 -0.42700  1.000 16.06000  ? 211 VAL A CA   1 
ATOM   3315 C C    . VAL A 1 211 ? 2.91200   -20.18900 0.91700   1.000 21.19000  ? 211 VAL A C    1 
ATOM   3316 O O    . VAL A 1 211 ? 3.46100   -20.64400 1.92100   1.000 25.88000  ? 211 VAL A O    1 
ATOM   3317 C CB   . VAL A 1 211 ? 3.04500   -22.27300 -0.47500  1.000 20.20000  ? 211 VAL A CB   1 
ATOM   3318 C CG1  . VAL A 1 211 ? 1.61200   -22.55600 -0.13700  1.000 25.59000  ? 211 VAL A CG1  1 
ATOM   3319 C CG2  . VAL A 1 211 ? 3.45900   -22.78400 -1.82300  1.000 20.41000  ? 211 VAL A CG2  1 
ATOM   3320 H H    . VAL A 1 211 ? 5.20600   -20.95200 -0.26900  1.000 18.22000  ? 211 VAL A H    1 
ATOM   3321 H HA   . VAL A 1 211 ? 2.69500   -20.33700 -1.09100  1.000 19.29000  ? 211 VAL A HA   1 
ATOM   3322 H HB   . VAL A 1 211 ? 3.58700   -22.74600 0.17600   1.000 24.26000  ? 211 VAL A HB   1 
ATOM   3323 H HG11 . VAL A 1 211 ? 1.31300   -23.32500 -0.64600  1.000 30.72000  ? 211 VAL A HG11 1 
ATOM   3324 H HG12 . VAL A 1 211 ? 1.54200   -22.74000 0.81300   1.000 30.72000  ? 211 VAL A HG12 1 
ATOM   3325 H HG13 . VAL A 1 211 ? 1.07500   -21.78000 -0.36400  1.000 30.72000  ? 211 VAL A HG13 1 
ATOM   3326 H HG21 . VAL A 1 211 ? 3.16800   -23.70400 -1.91500  1.000 24.52000  ? 211 VAL A HG21 1 
ATOM   3327 H HG22 . VAL A 1 211 ? 3.04600   -22.23600 -2.50900  1.000 24.52000  ? 211 VAL A HG22 1 
ATOM   3328 H HG23 . VAL A 1 211 ? 4.42500   -22.73300 -1.89700  1.000 24.52000  ? 211 VAL A HG23 1 
ATOM   3329 N N    . VAL A 1 212 ? 1.99300   -19.24700 0.94100   1.000 17.16000  ? 212 VAL A N    1 
ATOM   3330 C CA   . VAL A 1 212 ? 1.60500   -18.56600 2.15900   1.000 23.62000  ? 212 VAL A CA   1 
ATOM   3331 C C    . VAL A 1 212 ? 0.12300   -18.79300 2.45100   1.000 19.20000  ? 212 VAL A C    1 
ATOM   3332 O O    . VAL A 1 212 ? -0.71800  -18.67200 1.56500   1.000 18.94000  ? 212 VAL A O    1 
ATOM   3333 C CB   . VAL A 1 212 ? 1.89300   -17.06600 2.05300   1.000 30.18000  ? 212 VAL A CB   1 
ATOM   3334 C CG1  . VAL A 1 212 ? 1.53900   -16.34500 3.36200   1.000 38.20000  ? 212 VAL A CG1  1 
ATOM   3335 C CG2  . VAL A 1 212 ? 3.36400   -16.85700 1.71200   1.000 31.21000  ? 212 VAL A CG2  1 
ATOM   3336 H H    . VAL A 1 212 ? 1.56700   -18.97600 0.24500   1.000 20.61000  ? 212 VAL A H    1 
ATOM   3337 H HA   . VAL A 1 212 ? 2.10400   -18.95100 2.89700   1.000 28.36000  ? 212 VAL A HA   1 
ATOM   3338 H HB   . VAL A 1 212 ? 1.34500   -16.68300 1.35000   1.000 36.24000  ? 212 VAL A HB   1 
ATOM   3339 H HG11 . VAL A 1 212 ? 2.20500   -15.66300 3.53800   1.000 45.86000  ? 212 VAL A HG11 1 
ATOM   3340 H HG12 . VAL A 1 212 ? 0.66300   -15.93700 3.27200   1.000 45.86000  ? 212 VAL A HG12 1 
ATOM   3341 H HG13 . VAL A 1 212 ? 1.52900   -16.99200 4.08600   1.000 45.86000  ? 212 VAL A HG13 1 
ATOM   3342 H HG21 . VAL A 1 212 ? 3.53800   -15.90600 1.63300   1.000 37.48000  ? 212 VAL A HG21 1 
ATOM   3343 H HG22 . VAL A 1 212 ? 3.90900   -17.23500 2.42100   1.000 37.48000  ? 212 VAL A HG22 1 
ATOM   3344 H HG23 . VAL A 1 212 ? 3.56000   -17.30100 0.87200   1.000 37.48000  ? 212 VAL A HG23 1 
ATOM   3345 N N    . THR A 1 213 ? -0.16100  -19.09400 3.73200   1.000 23.73000  ? 213 THR A N    1 
ATOM   3346 C CA   . THR A 1 213 ? -1.52800  -19.34300 4.21100   1.000 22.26000  ? 213 THR A CA   1 
ATOM   3347 C C    . THR A 1 213 ? -2.02200  -18.14800 5.02000   1.000 26.86000  ? 213 THR A C    1 
ATOM   3348 O O    . THR A 1 213 ? -1.37600  -17.73800 5.99600   1.000 28.04000  ? 213 THR A O    1 
ATOM   3349 C CB   . THR A 1 213 ? -1.50700  -20.63100 5.00100   1.000 22.20000  ? 213 THR A CB   1 
ATOM   3350 O OG1  . THR A 1 213 ? -1.00200  -21.73300 4.25200   1.000 24.22000  ? 213 THR A OG1  1 
ATOM   3351 C CG2  . THR A 1 213 ? -2.94300  -20.98900 5.50200   1.000 26.06000  ? 213 THR A CG2  1 
ATOM   3352 H H    . THR A 1 213 ? 0.43400   -19.16000 4.34900   1.000 28.50000  ? 213 THR A H    1 
ATOM   3353 H HA   . THR A 1 213 ? -2.16100  -19.42400 3.48000   1.000 26.73000  ? 213 THR A HA   1 
ATOM   3354 H HB   . THR A 1 213 ? -0.91400  -20.49100 5.75600   1.000 26.66000  ? 213 THR A HB   1 
ATOM   3355 H HG1  . THR A 1 213 ? -0.65300  -22.29700 4.76900   1.000 29.08000  ? 213 THR A HG1  1 
ATOM   3356 H HG21 . THR A 1 213 ? -3.06600  -21.95100 5.49500   1.000 31.29000  ? 213 THR A HG21 1 
ATOM   3357 H HG22 . THR A 1 213 ? -3.07000  -20.66100 6.40600   1.000 31.29000  ? 213 THR A HG22 1 
ATOM   3358 H HG23 . THR A 1 213 ? -3.60600  -20.58200 4.92300   1.000 31.29000  ? 213 THR A HG23 1 
ATOM   3359 N N    . LYS A 1 214 ? -3.13800  -17.55600 4.61500   1.000 21.89000  ? 214 LYS A N    1 
ATOM   3360 C CA   . LYS A 1 214 ? -3.70300  -16.40800 5.32100   1.000 22.07000  ? 214 LYS A CA   1 
ATOM   3361 C C    . LYS A 1 214 ? -5.20600  -16.58600 5.52500   1.000 25.55000  ? 214 LYS A C    1 
ATOM   3362 O O    . LYS A 1 214 ? -5.91900  -17.00800 4.60800   1.000 23.67000  ? 214 LYS A O    1 
ATOM   3363 C CB   . LYS A 1 214 ? -3.48300  -15.09300 4.57700   1.000 28.13000  ? 214 LYS A CB   1 
ATOM   3364 C CG   . LYS A 1 214 ? -2.02200  -14.58900 4.63000   1.000 44.08000  ? 214 LYS A CG   1 
ATOM   3365 C CD   . LYS A 1 214 ? -1.89000  -13.34100 3.76300   1.000 59.15000  ? 214 LYS A CD   1 
ATOM   3366 C CE   . LYS A 1 214 ? -0.47000  -12.80500 3.73500   1.000 58.21000  ? 214 LYS A CE   1 
ATOM   3367 N NZ   . LYS A 1 214 ? -0.48500  -11.39600 3.28100   1.000 62.02000  ? 214 LYS A NZ   1 
ATOM   3368 H H    . LYS A 1 214 ? -3.59200  -17.80100 3.92700   1.000 26.29000  ? 214 LYS A H    1 
ATOM   3369 H HA   . LYS A 1 214 ? -3.26500  -16.35900 6.18500   1.000 26.51000  ? 214 LYS A HA   1 
ATOM   3370 N N    . GLU A 1 215 ? -5.71100  -16.16300 6.68600   1.000 23.57000  ? 215 GLU A N    1 
ATOM   3371 C CA   . GLU A 1 215 ? -7.14600  -16.18400 6.91200   1.000 21.69000  ? 215 GLU A CA   1 
ATOM   3372 C C    . GLU A 1 215 ? -7.83000  -15.12800 6.05800   1.000 24.32000  ? 215 GLU A C    1 
ATOM   3373 O O    . GLU A 1 215 ? -7.32300  -14.00300 5.91000   1.000 27.79000  ? 215 GLU A O    1 
ATOM   3374 C CB   . GLU A 1 215 ? -7.44100  -15.97100 8.40900   1.000 21.74000  ? 215 GLU A CB   1 
ATOM   3375 C CG   . GLU A 1 215 ? -8.86800  -16.17200 8.72300   1.000 26.53000  ? 215 GLU A CG   1 
ATOM   3376 C CD   . GLU A 1 215 ? -9.14900  -16.18300 10.20500  1.000 32.16000  ? 215 GLU A CD   1 
ATOM   3377 O OE1  . GLU A 1 215 ? -8.16600  -16.25900 10.97700  1.000 35.94000  ? 215 GLU A OE1  1 
ATOM   3378 O OE2  . GLU A 1 215 ? -10.35100 -16.07700 10.52500  1.000 34.67000  ? 215 GLU A OE2  1 
ATOM   3379 H H    . GLU A 1 215 ? -5.24700  -15.86500 7.34500   1.000 28.31000  ? 215 GLU A H    1 
ATOM   3380 H HA   . GLU A 1 215 ? -7.51400  -17.04500 6.66000   1.000 26.05000  ? 215 GLU A HA   1 
ATOM   3381 H HB2  . GLU A 1 215 ? -6.92300  -16.60500 8.93000   1.000 26.11000  ? 215 GLU A HB2  1 
ATOM   3382 H HB3  . GLU A 1 215 ? -7.20000  -15.06400 8.65600   1.000 26.11000  ? 215 GLU A HB3  1 
ATOM   3383 H HG2  . GLU A 1 215 ? -9.38300  -15.45100 8.32700   1.000 31.86000  ? 215 GLU A HG2  1 
ATOM   3384 H HG3  . GLU A 1 215 ? -9.15400  -17.02400 8.35800   1.000 31.86000  ? 215 GLU A HG3  1 
ATOM   3385 N N    . VAL A 1 216 ? -8.96000  -15.49400 5.45500   1.000 21.22000  ? 216 VAL A N    1 
ATOM   3386 C CA   . VAL A 1 216 ? -9.81800  -14.54900 4.75100   1.000 21.01000  ? 216 VAL A CA   1 
ATOM   3387 C C    . VAL A 1 216 ? -10.60700 -13.78200 5.79300   1.000 30.54000  ? 216 VAL A C    1 
ATOM   3388 O O    . VAL A 1 216 ? -11.35200 -14.37800 6.56100   1.000 31.17000  ? 216 VAL A O    1 
ATOM   3389 C CB   . VAL A 1 216 ? -10.76200 -15.26800 3.76900   1.000 21.99000  ? 216 VAL A CB   1 
ATOM   3390 C CG1  . VAL A 1 216 ? -11.72300 -14.25300 3.18300   1.000 28.57000  ? 216 VAL A CG1  1 
ATOM   3391 C CG2  . VAL A 1 216 ? -9.96600  -15.98000 2.74700   1.000 23.33000  ? 216 VAL A CG2  1 
ATOM   3392 H H    . VAL A 1 216 ? -9.25600  -16.30100 5.43900   1.000 25.48000  ? 216 VAL A H    1 
ATOM   3393 H HA   . VAL A 1 216 ? -9.27100  -13.93100 4.24100   1.000 25.23000  ? 216 VAL A HA   1 
ATOM   3394 H HB   . VAL A 1 216 ? -11.29800 -15.94200 4.21600   1.000 26.41000  ? 216 VAL A HB   1 
ATOM   3395 H HG11 . VAL A 1 216 ? -12.03200 -14.57200 2.32000   1.000 34.30000  ? 216 VAL A HG11 1 
ATOM   3396 H HG12 . VAL A 1 216 ? -12.47600 -14.14700 3.78500   1.000 34.30000  ? 216 VAL A HG12 1 
ATOM   3397 H HG13 . VAL A 1 216 ? -11.26300 -13.40600 3.07700   1.000 34.30000  ? 216 VAL A HG13 1 
ATOM   3398 H HG21 . VAL A 1 216 ? -10.56300 -16.32500 2.06500   1.000 28.02000  ? 216 VAL A HG21 1 
ATOM   3399 H HG22 . VAL A 1 216 ? -9.33300  -15.36100 2.35100   1.000 28.02000  ? 216 VAL A HG22 1 
ATOM   3400 H HG23 . VAL A 1 216 ? -9.49000  -16.71200 3.17100   1.000 28.02000  ? 216 VAL A HG23 1 
ATOM   3401 N N    . GLU A 1 217 ? -10.42700 -12.47300 5.83200   1.000 33.30000  ? 217 GLU A N    1 
ATOM   3402 C CA   . GLU A 1 217 ? -11.03000 -11.65600 6.87800   1.000 41.30000  ? 217 GLU A CA   1 
ATOM   3403 C C    . GLU A 1 217 ? -12.38500 -11.12400 6.43500   1.000 44.80000  ? 217 GLU A C    1 
ATOM   3404 O O    . GLU A 1 217 ? -12.70100 -11.06800 5.24500   1.000 43.70000  ? 217 GLU A O    1 
ATOM   3405 C CB   . GLU A 1 217 ? -10.11200 -10.48800 7.25400   1.000 45.98000  ? 217 GLU A CB   1 
ATOM   3406 C CG   . GLU A 1 217 ? -8.74200  -10.89000 7.80000   1.000 57.98000  ? 217 GLU A CG   1 
ATOM   3407 C CD   . GLU A 1 217 ? -8.80400  -11.63400 9.13000   1.000 65.73000  ? 217 GLU A CD   1 
ATOM   3408 O OE1  . GLU A 1 217 ? -9.89300  -11.70300 9.73900   1.000 78.17000  ? 217 GLU A OE1  1 
ATOM   3409 O OE2  . GLU A 1 217 ? -7.76100  -12.18700 9.55100   1.000 72.86000  ? 217 GLU A OE2  1 
ATOM   3410 H H    . GLU A 1 217 ? -9.95900  -12.02900 5.26300   1.000 39.98000  ? 217 GLU A H    1 
ATOM   3411 H HA   . GLU A 1 217 ? -11.16200 -12.20500 7.66700   1.000 49.58000  ? 217 GLU A HA   1 
ATOM   3412 H HB2  . GLU A 1 217 ? -9.96200  -9.94800  6.46200   1.000 55.20000  ? 217 GLU A HB2  1 
ATOM   3413 H HB3  . GLU A 1 217 ? -10.55300 -9.95900  7.93700   1.000 55.20000  ? 217 GLU A HB3  1 
ATOM   3414 H HG2  . GLU A 1 217 ? -8.30800  -11.47200 7.15600   1.000 69.60000  ? 217 GLU A HG2  1 
ATOM   3415 H HG3  . GLU A 1 217 ? -8.21100  -10.08900 7.93400   1.000 69.60000  ? 217 GLU A HG3  1 
ATOM   3416 N N    . LYS A 1 218 ? -13.17800 -10.71500 7.41700   1.000 57.64000  ? 218 LYS A N    1 
ATOM   3417 C CA   . LYS A 1 218 ? -14.51100 -10.16500 7.17100   1.000 65.56000  ? 218 LYS A CA   1 
ATOM   3418 C C    . LYS A 1 218 ? -14.45200 -8.64300  7.04100   1.000 48.09000  ? 218 LYS A C    1 
ATOM   3419 O O    . LYS A 1 218 ? -13.43200 -8.07600  6.62400   1.000 64.59000  ? 218 LYS A O    1 
ATOM   3420 C CB   . LYS A 1 218 ? -15.47100 -10.57200 8.30100   1.000 73.53000  ? 218 LYS A CB   1 
ATOM   3421 H H    . LYS A 1 218 ? -12.96700 -10.74400 8.25000   1.000 69.19000  ? 218 LYS A H    1 
ATOM   3422 H HA   . LYS A 1 218 ? -14.86100 -10.52200 6.34000   1.000 78.69000  ? 218 LYS A HA   1 
HETATM 3423 C C1   . 819 B 2 .   ? 24.36400  -36.30000 -0.63100  1.000 36.45000  ? 301 819 A C1   1 
HETATM 3424 C C2   . 819 B 2 .   ? 24.60100  -34.78300 -0.44800  1.000 28.95000  ? 301 819 A C2   1 
HETATM 3425 O O3   . 819 B 2 .   ? 24.71100  -34.18000 -1.69500  1.000 20.95000  ? 301 819 A O3   1 
HETATM 3426 C C4   . 819 B 2 .   ? 24.41500  -32.79700 -1.69300  1.000 23.21000  ? 301 819 A C4   1 
HETATM 3427 O O5   . 819 B 2 .   ? 24.34900  -32.19700 -0.68200  1.000 21.04000  ? 301 819 A O5   1 
HETATM 3428 N N6   . 819 B 2 .   ? 24.19300  -32.08800 -2.94700  1.000 22.10000  ? 301 819 A N6   1 
HETATM 3429 C C8   . 819 B 2 .   ? 24.38400  -32.77500 -4.22300  1.000 19.37000  ? 301 819 A C8   1 
HETATM 3430 C C9   . 819 B 2 .   ? 23.01900  -33.27100 -4.79700  1.000 17.22000  ? 301 819 A C9   1 
HETATM 3431 C C12  . 819 B 2 .   ? 22.69400  -34.60300 -4.74500  1.000 16.68000  ? 301 819 A C12  1 
HETATM 3432 C C13  . 819 B 2 .   ? 21.48300  -35.04800 -5.26800  1.000 17.62000  ? 301 819 A C13  1 
HETATM 3433 C C10  . 819 B 2 .   ? 22.13900  -32.37300 -5.38000  1.000 17.13000  ? 301 819 A C10  1 
HETATM 3434 C C11  . 819 B 2 .   ? 20.93600  -32.82000 -5.90100  1.000 17.30000  ? 301 819 A C11  1 
HETATM 3435 C C14  . 819 B 2 .   ? 20.60200  -34.15800 -5.85100  1.000 15.55000  ? 301 819 A C14  1 
HETATM 3436 N N15  . 819 B 2 .   ? 19.42700  -34.56800 -6.34800  1.000 15.38000  ? 301 819 A N15  1 
HETATM 3437 C C16  . 819 B 2 .   ? 19.23800  -35.28700 -7.46400  1.000 14.85000  ? 301 819 A C16  1 
HETATM 3438 S S17  . 819 B 2 .   ? 20.57100  -35.89300 -8.56400  1.000 19.82000  ? 301 819 A S17  1 
HETATM 3439 N N18  . 819 B 2 .   ? 17.96800  -35.47800 -7.62300  1.000 15.30000  ? 301 819 A N18  1 
HETATM 3440 N N20  . 819 B 2 .   ? 17.31700  -34.86600 -6.60000  1.000 14.24000  ? 301 819 A N20  1 
HETATM 3441 C C21  . 819 B 2 .   ? 18.22500  -34.32900 -5.82800  1.000 12.01000  ? 301 819 A C21  1 
HETATM 3442 C C22  . 819 B 2 .   ? 18.05800  -33.57300 -4.65100  1.000 12.61000  ? 301 819 A C22  1 
HETATM 3443 C C23  . 819 B 2 .   ? 18.80900  -33.90100 -3.51700  1.000 13.70000  ? 301 819 A C23  1 
HETATM 3444 C C24  . 819 B 2 .   ? 18.70400  -33.15400 -2.38300  1.000 13.74000  ? 301 819 A C24  1 
HETATM 3445 C C25  . 819 B 2 .   ? 19.52400  -33.54000 -1.11600  1.000 14.86000  ? 301 819 A C25  1 
HETATM 3446 C C27  . 819 B 2 .   ? 18.77800  -34.67700 -0.40800  1.000 15.75000  ? 301 819 A C27  1 
HETATM 3447 C C26  . 819 B 2 .   ? 20.93600  -34.04000 -1.51500  1.000 13.87000  ? 301 819 A C26  1 
HETATM 3448 C C28  . 819 B 2 .   ? 17.84400  -32.05500 -2.36400  1.000 14.04000  ? 301 819 A C28  1 
HETATM 3449 O O29  . 819 B 2 .   ? 17.73500  -31.28100 -1.20500  1.000 14.71000  ? 301 819 A O29  1 
HETATM 3450 C C31  . 819 B 2 .   ? 17.11900  -31.72200 -3.47300  1.000 13.73000  ? 301 819 A C31  1 
HETATM 3451 C C32  . 819 B 2 .   ? 17.22700  -32.49200 -4.63800  1.000 11.89000  ? 301 819 A C32  1 
HETATM 3452 O O33  . 819 B 2 .   ? 16.46700  -32.15100 -5.80400  1.000 13.78000  ? 301 819 A O33  1 
HETATM 3453 H H1   . 819 B 2 .   ? 25.30800  -36.78700 -0.86900  1.000 43.76000  ? 301 819 A H1   1 
HETATM 3454 H H1A  . 819 B 2 .   ? 23.65400  -36.46100 -1.44200  1.000 43.76000  ? 301 819 A H1A  1 
HETATM 3455 H H1B  . 819 B 2 .   ? 23.96100  -36.71600 0.29000   1.000 43.76000  ? 301 819 A H1B  1 
HETATM 3456 H H2   . 819 B 2 .   ? 25.51500  -34.61600 0.12300   1.000 34.76000  ? 301 819 A H2   1 
HETATM 3457 H H2A  . 819 B 2 .   ? 23.75400  -34.37800 0.09400   1.000 34.76000  ? 301 819 A H2A  1 
HETATM 3458 H HN6  . 819 B 2 .   ? 24.04900  -31.08000 -2.93700  1.000 26.54000  ? 301 819 A HN6  1 
HETATM 3459 H H8   . 819 B 2 .   ? 25.05700  -33.62800 -4.09100  1.000 23.26000  ? 301 819 A H8   1 
HETATM 3460 H H8A  . 819 B 2 .   ? 24.83300  -32.06800 -4.93900  1.000 23.26000  ? 301 819 A H8A  1 
HETATM 3461 H H12  . 819 B 2 .   ? 23.38700  -35.30800 -4.28900  1.000 20.04000  ? 301 819 A H12  1 
HETATM 3462 H H13  . 819 B 2 .   ? 21.23100  -36.08000 -5.22000  1.000 21.16000  ? 301 819 A H13  1 
HETATM 3463 H H10  . 819 B 2 .   ? 22.39300  -31.31600 -5.42900  1.000 20.58000  ? 301 819 A H10  1 
HETATM 3464 H H11  . 819 B 2 .   ? 20.24300  -32.11600 -6.35300  1.000 20.78000  ? 301 819 A H11  1 
HETATM 3465 H HS17 . 819 B 2 .   ? 21.31700  -34.86500 -8.95300  1.000 23.80000  ? 301 819 A HS17 1 
HETATM 3466 H H23  . 819 B 2 .   ? 19.47300  -34.75700 -3.54000  1.000 16.46000  ? 301 819 A H23  1 
HETATM 3467 H H25  . 819 B 2 .   ? 19.62300  -32.69400 -0.44600  1.000 17.85000  ? 301 819 A H25  1 
HETATM 3468 H H27  . 819 B 2 .   ? 18.55300  -35.45500 -1.11500  1.000 18.92000  ? 301 819 A H27  1 
HETATM 3469 H H27A . 819 B 2 .   ? 17.86100  -34.29100 0.01400   1.000 18.92000  ? 301 819 A H27A 1 
HETATM 3470 H H27B . 819 B 2 .   ? 19.40300  -35.07400 0.38300   1.000 18.92000  ? 301 819 A H27B 1 
HETATM 3471 H H26  . 819 B 2 .   ? 21.30400  -33.46200 -2.37000  1.000 16.66000  ? 301 819 A H26  1 
HETATM 3472 H H26A . 819 B 2 .   ? 20.87400  -35.09900 -1.78500  1.000 16.66000  ? 301 819 A H26A 1 
HETATM 3473 H H26B . 819 B 2 .   ? 21.62100  -33.92300 -0.67700  1.000 16.66000  ? 301 819 A H26B 1 
HETATM 3474 H HO29 . 819 B 2 .   ? 18.50500  -30.80300 -1.08100  1.000 17.67000  ? 301 819 A HO29 1 
HETATM 3475 H H31  . 819 B 2 .   ? 16.45800  -30.87200 -3.45000  1.000 16.50000  ? 301 819 A H31  1 
HETATM 3476 H HO33 . 819 B 2 .   ? 15.75000  -32.81000 -5.93400  1.000 16.55000  ? 301 819 A HO33 1 
HETATM 3477 C C1   . EDO C 3 .   ? 6.74700   -23.33100 -19.99600 1.000 57.33000  ? 302 EDO A C1   1 
HETATM 3478 O O1   . EDO C 3 .   ? 7.79900   -22.89700 -20.86900 1.000 69.15000  ? 302 EDO A O1   1 
HETATM 3479 C C2   . EDO C 3 .   ? 6.63600   -22.33900 -18.84300 1.000 67.48000  ? 302 EDO A C2   1 
HETATM 3480 O O2   . EDO C 3 .   ? 5.44300   -22.61500 -18.09700 1.000 84.03000  ? 302 EDO A O2   1 
HETATM 3481 H H11  . EDO C 3 .   ? 6.96600   -24.33000 -19.61200 1.000 68.81000  ? 302 EDO A H11  1 
HETATM 3482 H H12  . EDO C 3 .   ? 5.80300   -23.38100 -20.54100 1.000 68.81000  ? 302 EDO A H12  1 
HETATM 3483 H HO1  . EDO C 3 .   ? 7.81700   -23.45900 -21.65600 1.000 83.00000  ? 302 EDO A HO1  1 
HETATM 3484 H H21  . EDO C 3 .   ? 6.60400   -21.31900 -19.23200 1.000 80.99000  ? 302 EDO A H21  1 
HETATM 3485 H H22  . EDO C 3 .   ? 7.50900   -22.42300 -18.19400 1.000 80.99000  ? 302 EDO A H22  1 
HETATM 3486 H HO2  . EDO C 3 .   ? 5.30800   -21.92200 -17.43700 1.000 100.86000 ? 302 EDO A HO2  1 
HETATM 3487 O O    . HOH D 4 .   ? 14.25400  -43.31400 -17.68000 1.000 31.88000  ? 401 HOH A O    1 
HETATM 3488 O O    . HOH D 4 .   ? 21.50000  -18.04600 12.93700  1.000 32.80000  ? 402 HOH A O    1 
HETATM 3489 O O    . HOH D 4 .   ? 18.68400  -24.13000 18.18800  1.000 44.41000  ? 403 HOH A O    1 
HETATM 3490 O O    . HOH D 4 .   ? 6.47900   -34.52400 -24.59100 1.000 40.55000  ? 404 HOH A O    1 
HETATM 3491 O O    . HOH D 4 .   ? 13.34800  -51.40100 9.42500   1.000 46.42000  ? 405 HOH A O    1 
HETATM 3492 O O    . HOH D 4 .   ? 20.45200  -12.66200 8.90700   1.000 44.34000  ? 406 HOH A O    1 
HETATM 3493 O O    . HOH D 4 .   ? 34.05500  -41.04200 11.50600  1.000 37.06000  ? 407 HOH A O    1 
HETATM 3494 O O    . HOH D 4 .   ? 30.74600  -25.72700 13.58200  1.000 46.97000  ? 408 HOH A O    1 
HETATM 3495 O O    . HOH D 4 .   ? 1.85900   -12.57200 0.70800   1.000 48.19000  ? 409 HOH A O    1 
HETATM 3496 O O    . HOH D 4 .   ? 3.52200   -17.00200 12.77600  1.000 52.80000  ? 410 HOH A O    1 
HETATM 3497 O O    . HOH D 4 .   ? 22.716    -42.538   -9.111    1.000 47.69000  ? 411 HOH A O    1 
HETATM 3498 O O    . HOH D 4 .   ? 17.85100  -35.48200 16.05300  1.000 48.08000  ? 412 HOH A O    1 
HETATM 3499 O O    . HOH D 4 .   ? 24.25400  -28.13400 -12.11700 1.000 36.09000  ? 413 HOH A O    1 
HETATM 3500 O O    . HOH D 4 .   ? 9.50900   -42.60900 6.77000   1.000 26.14000  ? 414 HOH A O    1 
HETATM 3501 O O    . HOH D 4 .   ? 7.19700   -18.67100 13.20500  1.000 30.33000  ? 415 HOH A O    1 
HETATM 3502 O O    . HOH D 4 .   ? 25.785    -16.840   17.447    1.000 39.78000  ? 416 HOH A O    1 
HETATM 3503 O O    . HOH D 4 .   ? 16.41700  -43.77500 -17.31500 1.000 46.31000  ? 417 HOH A O    1 
HETATM 3504 O O    . HOH D 4 .   ? 44.14100  -23.05000 10.88100  1.000 34.15000  ? 418 HOH A O    1 
HETATM 3505 O O    . HOH D 4 .   ? 42.39000  -29.73200 9.62300   1.000 46.16000  ? 419 HOH A O    1 
HETATM 3506 O O    . HOH D 4 .   ? 20.86500  -23.46000 -13.63500 1.000 21.08000  ? 420 HOH A O    1 
HETATM 3507 O O    . HOH D 4 .   ? 8.87600   -39.91000 12.07100  1.000 53.85000  ? 421 HOH A O    1 
HETATM 3508 O O    . HOH D 4 .   ? 24.33400  -27.52300 -1.33600  1.000 29.56000  ? 422 HOH A O    1 
HETATM 3509 O O    . HOH D 4 .   ? 17.85400  -16.99200 14.85200  1.000 36.06000  ? 423 HOH A O    1 
HETATM 3510 O O    . HOH D 4 .   ? 29.84100  -16.83100 6.60000   1.000 56.07000  ? 424 HOH A O    1 
HETATM 3511 O O    . HOH D 4 .   ? 11.30900  -49.72400 -6.42300  1.000 31.53000  ? 425 HOH A O    1 
HETATM 3512 O O    . HOH D 4 .   ? 9.22900   -50.01300 1.28900   1.000 24.41000  ? 426 HOH A O    1 
HETATM 3513 O O    . HOH D 4 .   ? 23.02400  -11.51500 -4.79600  1.000 46.33000  ? 427 HOH A O    1 
HETATM 3514 O O    . HOH D 4 .   ? 41.403    -33.359   3.016     1.000 45.49000  ? 428 HOH A O    1 
HETATM 3515 O O    . HOH D 4 .   ? 18.70700  -18.79100 12.93000  1.000 25.18000  ? 429 HOH A O    1 
HETATM 3516 O O    . HOH D 4 .   ? 12.07900  -53.69800 1.40700   1.000 65.78000  ? 430 HOH A O    1 
HETATM 3517 O O    . HOH D 4 .   ? 3.22200   -39.15300 -20.40500 1.000 50.30000  ? 431 HOH A O    1 
HETATM 3518 O O    . HOH D 4 .   ? 16.32800  -29.06400 -1.48400  1.000 13.81000  ? 432 HOH A O    1 
HETATM 3519 O O    . HOH D 4 .   ? 14.88800  -48.06700 12.01000  1.000 43.28000  ? 433 HOH A O    1 
HETATM 3520 O O    . HOH D 4 .   ? 5.06000   -48.59500 6.35400   1.000 35.38000  ? 434 HOH A O    1 
HETATM 3521 O O    . HOH D 4 .   ? 21.10300  -38.96800 -7.42500  1.000 42.76000  ? 435 HOH A O    1 
HETATM 3522 O O    . HOH D 4 .   ? 12.41000  -8.04900  5.43300   1.000 39.98000  ? 436 HOH A O    1 
HETATM 3523 O O    . HOH D 4 .   ? 19.99900  -22.06200 -11.27700 1.000 18.63000  ? 437 HOH A O    1 
HETATM 3524 O O    . HOH D 4 .   ? 13.64700  -18.47100 15.17500  1.000 25.10000  ? 438 HOH A O    1 
HETATM 3525 O O    . HOH D 4 .   ? 25.46700  -38.60800 1.75700   1.000 39.78000  ? 439 HOH A O    1 
HETATM 3526 O O    . HOH D 4 .   ? 23.72500  -36.78700 16.05800  1.000 50.60000  ? 440 HOH A O    1 
HETATM 3527 O O    . HOH D 4 .   ? 18.84700  -45.58200 -9.73400  1.000 25.97000  ? 441 HOH A O    1 
HETATM 3528 O O    . HOH D 4 .   ? 1.78700   -27.37400 -16.63600 1.000 35.31000  ? 442 HOH A O    1 
HETATM 3529 O O    . HOH D 4 .   ? 3.03200   -29.69700 0.71700   1.000 30.69000  ? 443 HOH A O    1 
HETATM 3530 O O    . HOH D 4 .   ? -0.17000  -29.33500 -2.22100  1.000 33.29000  ? 444 HOH A O    1 
HETATM 3531 O O    . HOH D 4 .   ? 15.16500  -16.79900 -12.33800 1.000 49.31000  ? 445 HOH A O    1 
HETATM 3532 O O    . HOH D 4 .   ? 25.20600  -38.52500 14.15700  1.000 38.32000  ? 446 HOH A O    1 
HETATM 3533 O O    . HOH D 4 .   ? 27.18900  -32.73700 -21.69700 1.000 33.29000  ? 447 HOH A O    1 
HETATM 3534 O O    . HOH D 4 .   ? 25.99600  -42.31300 1.00300   1.000 36.01000  ? 448 HOH A O    1 
HETATM 3535 O O    . HOH D 4 .   ? 3.47500   -28.96200 16.00800  1.000 49.56000  ? 449 HOH A O    1 
HETATM 3536 O O    . HOH D 4 .   ? 7.69500   -32.30700 -22.86200 1.000 35.72000  ? 450 HOH A O    1 
HETATM 3537 O O    . HOH D 4 .   ? 26.83500  -47.85600 5.78000   1.000 55.02000  ? 451 HOH A O    1 
HETATM 3538 O O    . HOH D 4 .   ? 11.70100  -41.74700 -23.99900 1.000 37.18000  ? 452 HOH A O    1 
HETATM 3539 O O    . HOH D 4 .   ? 22.26900  -25.30700 -10.45300 1.000 19.74000  ? 453 HOH A O    1 
HETATM 3540 O O    . HOH D 4 .   ? 9.17200   -22.66300 -14.59300 1.000 27.60000  ? 454 HOH A O    1 
HETATM 3541 O O    . HOH D 4 .   ? -11.85600 -16.59400 8.34200   1.000 24.91000  ? 455 HOH A O    1 
HETATM 3542 O O    . HOH D 4 .   ? 14.49800  -17.40800 -9.46400  1.000 32.35000  ? 456 HOH A O    1 
HETATM 3543 O O    . HOH D 4 .   ? 0.36700   -18.60700 7.87200   1.000 40.92000  ? 457 HOH A O    1 
HETATM 3544 O O    . HOH D 4 .   ? 11.96500  -42.49300 -7.32500  1.000 16.75000  ? 458 HOH A O    1 
HETATM 3545 O O    . HOH D 4 .   ? 17.47900  -51.33800 -0.58000  1.000 48.96000  ? 459 HOH A O    1 
HETATM 3546 O O    . HOH D 4 .   ? -2.65800  -31.69400 -5.12400  1.000 33.92000  ? 460 HOH A O    1 
HETATM 3547 O O    . HOH D 4 .   ? 24.48500  -23.29000 14.41100  1.000 29.42000  ? 461 HOH A O    1 
HETATM 3548 O O    . HOH D 4 .   ? 28.56000  -23.56200 0.45700   1.000 31.07000  ? 462 HOH A O    1 
HETATM 3549 O O    . HOH D 4 .   ? 9.23000   -22.52700 20.24100  1.000 52.29000  ? 463 HOH A O    1 
HETATM 3550 O O    . HOH D 4 .   ? 18.00900  -14.46200 12.57100  1.000 40.12000  ? 464 HOH A O    1 
HETATM 3551 O O    . HOH D 4 .   ? 11.10100  -9.79000  3.72900   1.000 28.45000  ? 465 HOH A O    1 
HETATM 3552 O O    . HOH D 4 .   ? 7.93300   -41.75200 10.19300  1.000 50.75000  ? 466 HOH A O    1 
HETATM 3553 O O    . HOH D 4 .   ? 5.28400   -32.02700 13.36300  1.000 38.08000  ? 467 HOH A O    1 
HETATM 3554 O O    . HOH D 4 .   ? -1.31500  -24.37800 4.84300   1.000 37.53000  ? 468 HOH A O    1 
HETATM 3555 O O    . HOH D 4 .   ? 36.445    -21.250   -3.685    1.000 48.44000  ? 469 HOH A O    1 
HETATM 3556 O O    . HOH D 4 .   ? 14.73900  -33.63400 -7.54500  1.000 14.65000  ? 470 HOH A O    1 
HETATM 3557 O O    . HOH D 4 .   ? 8.68900   -39.29000 -12.17100 1.000 18.90000  ? 471 HOH A O    1 
HETATM 3558 O O    . HOH D 4 .   ? 15.96500  -15.68700 -6.98000  1.000 45.15000  ? 472 HOH A O    1 
HETATM 3559 O O    . HOH D 4 .   ? 11.05500  -28.68900 17.47800  1.000 42.01000  ? 473 HOH A O    1 
HETATM 3560 O O    . HOH D 4 .   ? 7.92400   -32.03000 -7.37700  1.000 22.21000  ? 474 HOH A O    1 
HETATM 3561 O O    . HOH D 4 .   ? 18.74800  -12.99700 5.77100   1.000 33.24000  ? 475 HOH A O    1 
HETATM 3562 O O    . HOH D 4 .   ? 4.82400   -39.51100 -12.14600 1.000 28.97000  ? 476 HOH A O    1 
HETATM 3563 O O    . HOH D 4 .   ? 1.88800   -31.84900 0.19400   1.000 38.34000  ? 477 HOH A O    1 
HETATM 3564 O O    . HOH D 4 .   ? 24.23800  -19.65000 17.62100  1.000 37.07000  ? 478 HOH A O    1 
HETATM 3565 O O    . HOH D 4 .   ? 9.42600   -40.76600 -21.38700 1.000 48.13000  ? 479 HOH A O    1 
HETATM 3566 O O    . HOH D 4 .   ? 20.75800  -20.92500 -3.57000  1.000 21.50000  ? 480 HOH A O    1 
HETATM 3567 O O    . HOH D 4 .   ? 5.14000   -43.09200 5.10800   1.000 33.79000  ? 481 HOH A O    1 
HETATM 3568 O O    . HOH D 4 .   ? 4.95800   -44.72300 -3.85000  1.000 26.22000  ? 482 HOH A O    1 
HETATM 3569 O O    . HOH D 4 .   ? 16.29800  -40.15700 -19.54200 1.000 39.47000  ? 483 HOH A O    1 
HETATM 3570 O O    . HOH D 4 .   ? 4.43300   -18.43700 6.21600   1.000 23.19000  ? 484 HOH A O    1 
HETATM 3571 O O    . HOH D 4 .   ? 20.96700  -28.28500 -17.76200 1.000 29.42000  ? 485 HOH A O    1 
HETATM 3572 O O    . HOH D 4 .   ? 2.23400   -10.76400 3.40100   1.000 46.85000  ? 486 HOH A O    1 
HETATM 3573 O O    . HOH D 4 .   ? 11.49000  -44.02200 5.48800   1.000 19.42000  ? 487 HOH A O    1 
HETATM 3574 O O    . HOH D 4 .   ? 19.14500  -42.71600 -11.14700 1.000 32.21000  ? 488 HOH A O    1 
HETATM 3575 O O    . HOH D 4 .   ? 21.41100  -16.79300 9.98700   1.000 27.00000  ? 489 HOH A O    1 
HETATM 3576 O O    . HOH D 4 .   ? 25.54300  -16.66100 0.21400   1.000 31.13000  ? 490 HOH A O    1 
HETATM 3577 O O    . HOH D 4 .   ? 7.77200   -50.14200 -9.98300  1.000 51.55000  ? 491 HOH A O    1 
HETATM 3578 O O    . HOH D 4 .   ? 13.94100  -29.46900 -2.85800  1.000 15.31000  ? 492 HOH A O    1 
HETATM 3579 O O    . HOH D 4 .   ? 13.42600  -38.34100 -13.47800 1.000 19.14000  ? 493 HOH A O    1 
HETATM 3580 O O    . HOH D 4 .   ? 21.05000  -10.42600 -3.23900  1.000 44.87000  ? 494 HOH A O    1 
HETATM 3581 O O    . HOH D 4 .   ? 5.54200   -38.53400 -25.63200 1.000 46.76000  ? 495 HOH A O    1 
HETATM 3582 O O    . HOH D 4 .   ? 29.32100  -29.05800 16.97900  1.000 34.15000  ? 496 HOH A O    1 
HETATM 3583 O O    . HOH D 4 .   ? 4.67000   -45.07600 3.32200   1.000 27.92000  ? 497 HOH A O    1 
HETATM 3584 O O    . HOH D 4 .   ? 3.55700   -38.95700 5.67700   1.000 33.72000  ? 498 HOH A O    1 
HETATM 3585 O O    . HOH D 4 .   ? 17.33700  -9.87600  1.80600   1.000 26.11000  ? 499 HOH A O    1 
HETATM 3586 O O    . HOH D 4 .   ? 29.46500  -17.99100 14.12800  1.000 25.86000  ? 500 HOH A O    1 
HETATM 3587 O O    . HOH D 4 .   ? 17.23300  -13.05900 -10.26800 1.000 49.28000  ? 501 HOH A O    1 
HETATM 3588 O O    . HOH D 4 .   ? 11.76000  -20.13000 17.35500  1.000 24.08000  ? 502 HOH A O    1 
HETATM 3589 O O    . HOH D 4 .   ? 18.96800  -39.29200 -9.35300  1.000 28.81000  ? 503 HOH A O    1 
HETATM 3590 O O    . HOH D 4 .   ? 20.46400  -19.10900 2.57500   1.000 33.67000  ? 504 HOH A O    1 
HETATM 3591 O O    . HOH D 4 .   ? 35.47900  -23.77600 12.09400  1.000 30.20000  ? 505 HOH A O    1 
HETATM 3592 O O    . HOH D 4 .   ? 33.76200  -29.81000 -4.63400  1.000 35.79000  ? 506 HOH A O    1 
HETATM 3593 O O    . HOH D 4 .   ? 12.12800  -49.49400 1.20500   1.000 33.65000  ? 507 HOH A O    1 
HETATM 3594 O O    . HOH D 4 .   ? 2.29700   -34.02300 -19.01200 1.000 34.59000  ? 508 HOH A O    1 
HETATM 3595 O O    . HOH D 4 .   ? 23.24100  -26.43400 14.93800  1.000 23.97000  ? 509 HOH A O    1 
HETATM 3596 O O    . HOH D 4 .   ? 4.89400   -44.01500 -6.87900  1.000 30.48000  ? 510 HOH A O    1 
HETATM 3597 O O    . HOH D 4 .   ? -1.01500  -45.39800 3.73800   1.000 31.81000  ? 511 HOH A O    1 
HETATM 3598 O O    . HOH D 4 .   ? -4.79800  -24.10600 11.29600  1.000 30.96000  ? 512 HOH A O    1 
HETATM 3599 O O    . HOH D 4 .   ? 3.20500   -51.63300 0.17900   1.000 47.25000  ? 513 HOH A O    1 
HETATM 3600 O O    . HOH D 4 .   ? 18.58500  -18.54800 0.27000   1.000 22.03000  ? 514 HOH A O    1 
HETATM 3601 O O    . HOH D 4 .   ? 24.24500  -27.95000 -4.63100  1.000 31.04000  ? 515 HOH A O    1 
HETATM 3602 O O    . HOH D 4 .   ? 10.83400  -51.36000 -2.30200  1.000 41.05000  ? 516 HOH A O    1 
HETATM 3603 O O    . HOH D 4 .   ? -0.16500  -24.80200 9.51700   1.000 35.58000  ? 517 HOH A O    1 
HETATM 3604 O O    . HOH D 4 .   ? 14.79900  -38.98800 -15.79600 1.000 31.36000  ? 518 HOH A O    1 
HETATM 3605 O O    . HOH D 4 .   ? 11.72200  -43.65500 9.97500   1.000 38.42000  ? 519 HOH A O    1 
HETATM 3606 O O    . HOH D 4 .   ? 22.01700  -47.99200 -3.48600  1.000 37.45000  ? 520 HOH A O    1 
HETATM 3607 O O    . HOH D 4 .   ? 4.80200   -39.05000 -7.72800  1.000 19.56000  ? 521 HOH A O    1 
HETATM 3608 O O    . HOH D 4 .   ? 2.46700   -43.33400 -6.60900  1.000 42.52000  ? 522 HOH A O    1 
HETATM 3609 O O    . HOH D 4 .   ? 4.86000   -22.98100 14.50900  1.000 44.83000  ? 523 HOH A O    1 
HETATM 3610 O O    . HOH D 4 .   ? 26.27600  -24.67000 -2.39300  1.000 42.23000  ? 524 HOH A O    1 
HETATM 3611 O O    . HOH D 4 .   ? 25.13300  -22.50900 -2.69500  1.000 43.50000  ? 525 HOH A O    1 
HETATM 3612 O O    . HOH D 4 .   ? 24.88500  -16.84000 -2.19200  1.000 38.55000  ? 526 HOH A O    1 
HETATM 3613 O O    . HOH D 4 .   ? 15.69800  -28.70800 -21.84100 1.000 35.86000  ? 527 HOH A O    1 
HETATM 3614 O O    . HOH D 4 .   ? 9.47700   -29.39300 14.28700  1.000 23.88000  ? 528 HOH A O    1 
HETATM 3615 O O    . HOH D 4 .   ? 0.23000   -26.90000 8.39700   1.000 40.51000  ? 529 HOH A O    1 
HETATM 3616 O O    . HOH D 4 .   ? 31.16400  -35.41800 15.39900  1.000 34.24000  ? 530 HOH A O    1 
HETATM 3617 O O    . HOH D 4 .   ? -5.62100  -12.40400 7.53500   1.000 43.29000  ? 531 HOH A O    1 
HETATM 3618 O O    . HOH D 4 .   ? 17.63500  -11.23600 -4.91400  1.000 32.55000  ? 532 HOH A O    1 
HETATM 3619 O O    . HOH D 4 .   ? 15.93800  -10.81900 9.99000   1.000 44.79000  ? 533 HOH A O    1 
HETATM 3620 O O    . HOH D 4 .   ? 2.67000   -34.54000 1.20000   1.000 25.25000  ? 534 HOH A O    1 
HETATM 3621 O O    . HOH D 4 .   ? 2.97600   -37.49700 -13.02900 1.000 37.66000  ? 535 HOH A O    1 
HETATM 3622 O O    . HOH D 4 .   ? 35.86600  -30.87600 12.59800  1.000 34.49000  ? 536 HOH A O    1 
HETATM 3623 O O    . HOH D 4 .   ? 8.59900   -45.28400 7.37200   1.000 31.78000  ? 537 HOH A O    1 
HETATM 3624 O O    . HOH D 4 .   ? 2.37600   -14.39700 6.05100   1.000 37.89000  ? 538 HOH A O    1 
HETATM 3625 O O    . HOH D 4 .   ? 9.07700   -26.22600 -17.99900 1.000 41.48000  ? 539 HOH A O    1 
HETATM 3626 O O    . HOH D 4 .   ? 15.74200  -48.03300 -7.06300  1.000 24.78000  ? 540 HOH A O    1 
HETATM 3627 O O    . HOH D 4 .   ? 1.91300   -22.33200 3.69500   1.000 29.34000  ? 541 HOH A O    1 
HETATM 3628 O O    . HOH D 4 .   ? 17.68900  -35.26700 -29.24700 1.000 37.52000  ? 542 HOH A O    1 
HETATM 3629 O O    . HOH D 4 .   ? 16.06800  -17.99500 18.30900  1.000 47.87000  ? 543 HOH A O    1 
HETATM 3630 O O    . HOH D 4 .   ? 7.07300   -28.94600 -20.12600 1.000 36.86000  ? 544 HOH A O    1 
HETATM 3631 O O    . HOH D 4 .   ? 4.73600   -34.76400 -1.18200  1.000 26.44000  ? 545 HOH A O    1 
HETATM 3632 O O    . HOH D 4 .   ? 20.27500  -10.53100 -11.20200 1.000 42.10000  ? 546 HOH A O    1 
HETATM 3633 O O    . HOH D 4 .   ? 19.29600  -39.92400 -12.80900 1.000 33.65000  ? 547 HOH A O    1 
HETATM 3634 O O    . HOH D 4 .   ? 17.59600  -37.81300 -22.18900 1.000 28.24000  ? 548 HOH A O    1 
HETATM 3635 O O    . HOH D 4 .   ? 25.14600  -48.45000 -0.40600  1.000 42.73000  ? 549 HOH A O    1 
HETATM 3636 O O    . HOH D 4 .   ? 2.80100   -27.94600 -3.73900  1.000 34.49000  ? 550 HOH A O    1 
HETATM 3637 O O    . HOH D 4 .   ? 12.45700  -48.45500 -14.32400 1.000 52.78000  ? 551 HOH A O    1 
HETATM 3638 O O    . HOH D 4 .   ? 6.40800   -43.92700 -12.27900 1.000 44.02000  ? 552 HOH A O    1 
HETATM 3639 O O    . HOH D 4 .   ? 23.35600  -14.34200 9.53700   1.000 54.71000  ? 553 HOH A O    1 
HETATM 3640 O O    . HOH D 4 .   ? -0.85500  -29.36000 5.37300   1.000 33.22000  ? 554 HOH A O    1 
HETATM 3641 O O    . HOH D 4 .   ? 22.36100  -14.10000 -3.84800  1.000 29.81000  ? 555 HOH A O    1 
HETATM 3642 O O    . HOH D 4 .   ? 15.69600  -53.15200 7.40300   1.000 38.96000  ? 556 HOH A O    1 
HETATM 3643 O O    . HOH D 4 .   ? 25.68800  -31.45000 -10.15600 1.000 48.05000  ? 557 HOH A O    1 
HETATM 3644 O O    . HOH D 4 .   ? 22.25900  -20.88100 -10.85500 1.000 24.93000  ? 558 HOH A O    1 
HETATM 3645 O O    . HOH D 4 .   ? 12.80800  -29.82200 -23.73300 1.000 55.95000  ? 559 HOH A O    1 
HETATM 3646 O O    . HOH D 4 .   ? 11.98900  -11.12600 9.46100   1.000 46.62000  ? 560 HOH A O    1 
HETATM 3647 O O    . HOH D 4 .   ? 1.88600   -29.16100 -14.28100 1.000 33.66000  ? 561 HOH A O    1 
HETATM 3648 O O    . HOH D 4 .   ? 1.57400   -22.73100 7.34500   1.000 23.57000  ? 562 HOH A O    1 
HETATM 3649 O O    . HOH D 4 .   ? 31.52200  -46.55600 7.88100   1.000 34.96000  ? 563 HOH A O    1 
HETATM 3650 O O    . HOH D 4 .   ? 14.29100  -28.07000 19.55400  1.000 30.59000  ? 564 HOH A O    1 
HETATM 3651 O O    . HOH D 4 .   ? 5.93500   -12.89200 7.74000   1.000 26.94000  ? 565 HOH A O    1 
HETATM 3652 O O    . HOH D 4 .   ? 20.84600  -25.43600 17.46600  1.000 35.03000  ? 566 HOH A O    1 
HETATM 3653 O O    . HOH D 4 .   ? 8.71300   -52.81500 8.07500   1.000 42.63000  ? 567 HOH A O    1 
HETATM 3654 O O    . HOH D 4 .   ? 6.54600   -39.11700 5.19500   1.000 24.75000  ? 568 HOH A O    1 
HETATM 3655 O O    . HOH D 4 .   ? 7.94400   -38.39000 -18.08200 1.000 30.38000  ? 569 HOH A O    1 
HETATM 3656 O O    . HOH D 4 .   ? 9.84700   -49.40000 -9.81500  1.000 44.64000  ? 570 HOH A O    1 
HETATM 3657 O O    . HOH D 4 .   ? 4.39300   -35.18200 8.40300   1.000 47.62000  ? 571 HOH A O    1 
HETATM 3658 O O    . HOH D 4 .   ? 22.60000  -16.77000 -5.90200  1.000 33.63000  ? 572 HOH A O    1 
HETATM 3659 O O    . HOH D 4 .   ? 20.11800  -19.39800 16.47400  1.000 43.96000  ? 573 HOH A O    1 
HETATM 3660 O O    . HOH D 4 .   ? 26.17600  -26.43300 -4.01100  1.000 42.61000  ? 574 HOH A O    1 
HETATM 3661 O O    . HOH D 4 .   ? -2.37800  -16.18300 1.36700   1.000 34.02000  ? 575 HOH A O    1 
HETATM 3662 O O    . HOH D 4 .   ? 8.38600   -24.48000 -16.33200 1.000 28.16000  ? 576 HOH A O    1 
HETATM 3663 O O    . HOH D 4 .   ? 2.41100   -28.31900 -8.72800  1.000 45.72000  ? 577 HOH A O    1 
HETATM 3664 O O    . HOH D 4 .   ? 36.45800  -20.29800 5.66900   1.000 26.25000  ? 578 HOH A O    1 
HETATM 3665 O O    . HOH D 4 .   ? 26.32400  -29.40900 -1.72700  1.000 26.82000  ? 579 HOH A O    1 
HETATM 3666 O O    . HOH D 4 .   ? 14.72300  -41.48200 -16.76600 1.000 40.09000  ? 580 HOH A O    1 
HETATM 3667 O O    . HOH D 4 .   ? 4.06000   -15.68900 7.67600   1.000 23.89000  ? 581 HOH A O    1 
HETATM 3668 O O    . HOH D 4 .   ? -1.41000  -36.59200 -4.56500  1.000 22.77000  ? 582 HOH A O    1 
HETATM 3669 O O    . HOH D 4 .   ? 10.20200  -37.11250 -26.92800 0.50  32.41000  ? 583 HOH A O    1 
HETATM 3670 O O    . HOH D 4 .   ? 22.83800  -23.55700 17.97400  1.000 47.30000  ? 584 HOH A O    1 
HETATM 3671 O O    . HOH D 4 .   ? 33.92500  -35.30600 15.33100  1.000 43.25000  ? 585 HOH A O    1 
HETATM 3672 O O    . HOH D 4 .   ? 18.312    -26.527   -21.687   1.000 42.77000  ? 586 HOH A O    1 
HETATM 3673 O O    . HOH D 4 .   ? -3.81300  -15.54600 8.98500   1.000 34.34000  ? 587 HOH A O    1 
HETATM 3674 O O    . HOH D 4 .   ? 23.36800  -50.28900 5.80700   1.000 44.30000  ? 588 HOH A O    1 
HETATM 3675 O O    . HOH D 4 .   ? 18.41400  -41.09200 -15.60100 1.000 35.32000  ? 589 HOH A O    1 
HETATM 3676 O O    . HOH D 4 .   ? 30.16300  -24.75900 17.67900  1.000 35.21000  ? 590 HOH A O    1 
HETATM 3677 O O    . HOH D 4 .   ? 32.45300  -21.75700 11.09900  1.000 29.02000  ? 591 HOH A O    1 
HETATM 3678 O O    . HOH D 4 .   ? 20.76100  -29.76000 18.91800  1.000 49.05000  ? 592 HOH A O    1 
HETATM 3679 O O    . HOH D 4 .   ? 6.24300   -19.05300 -10.74800 1.000 31.09000  ? 593 HOH A O    1 
HETATM 3680 O O    . HOH D 4 .   ? 8.62500   -47.74100 -11.46400 1.000 45.90000  ? 594 HOH A O    1 
HETATM 3681 O O    . HOH D 4 .   ? 22.42400  -18.74700 15.48200  1.000 36.33000  ? 595 HOH A O    1 
HETATM 3682 O O    . HOH D 4 .   ? 29.099    -39.462   14.934    1.000 42.64000  ? 596 HOH A O    1 
HETATM 3683 O O    . HOH D 4 .   ? 24.85000  -31.85300 -7.63200  1.000 52.69000  ? 597 HOH A O    1 
HETATM 3684 O O    . HOH D 4 .   ? 4.573     -14.744   -1.113    1.000 36.38000  ? 598 HOH A O    1 
HETATM 3685 O O    . HOH D 4 .   ? 30.23200  -34.01600 17.25200  1.000 46.29000  ? 599 HOH A O    1 
HETATM 3686 O O    . HOH D 4 .   ? 5.46400   -37.32500 9.46200   1.000 47.71000  ? 600 HOH A O    1 
HETATM 3687 O O    . HOH D 4 .   ? 4.15500   -33.47200 11.81400  1.000 44.89000  ? 601 HOH A O    1 
HETATM 3688 O O    . HOH D 4 .   ? 2.04200   -19.92300 5.97700   1.000 25.17000  ? 602 HOH A O    1 
HETATM 3689 O O    . HOH D 4 .   ? -6.57700  -14.49800 2.63000   1.000 36.49000  ? 603 HOH A O    1 
HETATM 3690 O O    . HOH D 4 .   ? 31.14500  -27.04400 16.25800  1.000 46.71000  ? 604 HOH A O    1 
HETATM 3691 O O    . HOH D 4 .   ? 3.85000   -29.58700 -2.30200  1.000 38.43000  ? 605 HOH A O    1 
HETATM 3692 O O    . HOH D 4 .   ? 31.98100  -42.24400 13.46400  0.50  45.74000  ? 606 HOH A O    1 
HETATM 3693 O O    . HOH D 4 .   ? -8.882    -11.103   3.220     1.000 29.77000  ? 607 HOH A O    1 
HETATM 3694 O O    . HOH D 4 .   ? 1.80300   -34.38900 -9.46800  1.000 46.71000  ? 608 HOH A O    1 
HETATM 3695 O O    . HOH D 4 .   ? 23.74100  -23.74100 -13.46400 0.50  36.46000  ? 609 HOH A O    1 
HETATM 3696 O O    . HOH D 4 .   ? 4.76200   -11.04800 5.85000   1.000 54.18000  ? 610 HOH A O    1 
HETATM 3697 O O    . HOH D 4 .   ? 7.22600   -12.10700 10.15300  1.000 41.21000  ? 611 HOH A O    1 
HETATM 3698 O O    . HOH D 4 .   ? 22.63000  -19.66400 -4.98300  1.000 40.78000  ? 612 HOH A O    1 
HETATM 3699 O O    . HOH D 4 .   ? 3.37300   -46.98800 4.63600   1.000 35.62000  ? 613 HOH A O    1 
HETATM 3700 O O    . HOH D 4 .   ? 6.152     -22.671   -13.150   1.000 43.09000  ? 614 HOH A O    1 
HETATM 3701 O O    . HOH D 4 .   ? 9.81300   -12.61600 9.90300   1.000 33.39000  ? 615 HOH A O    1 
HETATM 3702 O O    . HOH D 4 .   ? 9.97200   -34.20700 14.83100  1.000 43.53000  ? 616 HOH A O    1 
HETATM 3703 O O    . HOH D 4 .   ? 31.79300  -31.58700 -4.48100  1.000 43.56000  ? 617 HOH A O    1 
HETATM 3704 O O    . HOH D 4 .   ? 5.94900   -40.66400 -24.10900 1.000 54.84000  ? 618 HOH A O    1 
HETATM 3705 O O    . HOH D 4 .   ? 23.53400  -50.48500 0.96500   1.000 57.86000  ? 619 HOH A O    1 
HETATM 3706 O O    . HOH D 4 .   ? 8.93700   -41.44900 -25.48800 1.000 37.26000  ? 620 HOH A O    1 
HETATM 3707 O O    . HOH D 4 .   ? 18.26600  -12.28000 10.91900  1.000 47.57000  ? 621 HOH A O    1 
HETATM 3708 O O    . HOH D 4 .   ? 5.34100   -39.29400 -18.05100 1.000 40.95000  ? 622 HOH A O    1 
HETATM 3709 O O    . HOH D 4 .   ? -1.49100  -19.61400 8.99500   1.000 45.47000  ? 623 HOH A O    1 
HETATM 3710 O O    . HOH D 4 .   ? 23.160    -26.230   -16.757   1.000 43.18000  ? 624 HOH A O    1 
HETATM 3711 O O    . HOH D 4 .   ? 14.52300  -42.27300 11.31400  1.000 50.29000  ? 625 HOH A O    1 
HETATM 3712 O O    . HOH D 4 .   ? 16.333    -25.159   -21.320   1.000 46.65000  ? 626 HOH A O    1 
HETATM 3713 O O    . HOH D 4 .   ? 20.56000  -28.16700 -20.55900 1.000 34.60000  ? 627 HOH A O    1 
HETATM 3714 O O    . HOH D 4 .   ? 22.47100  -22.10800 -7.44300  1.000 46.47000  ? 628 HOH A O    1 
HETATM 3715 O O    . HOH D 4 .   ? 4.21200   -44.10600 -10.80600 1.000 47.30000  ? 629 HOH A O    1 
HETATM 3716 O O    . HOH D 4 .   ? 12.86700  -18.24600 18.94800  1.000 45.28000  ? 630 HOH A O    1 
HETATM 3717 O O    . HOH D 4 .   ? 30.958    -21.811   15.213    1.000 44.98000  ? 631 HOH A O    1 
HETATM 3718 O O    . HOH D 4 .   ? 20.83900  -15.51300 12.08900  1.000 40.35000  ? 632 HOH A O    1 
HETATM 3719 O O    . HOH D 4 .   ? 6.42200   -10.41300 3.57700   1.000 37.34000  ? 633 HOH A O    1 
HETATM 3720 O O    . HOH D 4 .   ? -3.90500  -18.57000 8.76400   1.000 38.70000  ? 634 HOH A O    1 
HETATM 3721 O O    . HOH D 4 .   ? 26.93100  -30.07100 -4.29500  1.000 38.09000  ? 635 HOH A O    1 
HETATM 3722 O O    . HOH D 4 .   ? 35.91100  -43.02200 10.77700  1.000 31.79000  ? 636 HOH A O    1 
HETATM 3723 O O    . HOH D 4 .   ? 15.59400  -13.99900 -5.77000  1.000 48.89000  ? 637 HOH A O    1 
HETATM 3724 O O    . HOH D 4 .   ? -2.17600  -34.38300 -6.13800  1.000 42.17000  ? 638 HOH A O    1 
HETATM 3725 O O    . HOH D 4 .   ? 18.61800  -8.85800  -0.49400  1.000 38.25000  ? 639 HOH A O    1 
HETATM 3726 O O    . HOH D 4 .   ? 23.133    -23.467   -17.248   1.000 44.21000  ? 640 HOH A O    1 
HETATM 3727 O O    . HOH D 4 .   ? 0.10500   -25.05600 2.95200   1.000 36.21000  ? 641 HOH A O    1 
HETATM 3728 O O    . HOH D 4 .   ? 12.50300  -9.36800  1.47200   1.000 31.97000  ? 642 HOH A O    1 
HETATM 3729 O O    . HOH D 4 .   ? 27.41300  -16.43100 4.20800   1.000 55.11000  ? 643 HOH A O    1 
HETATM 3730 O O    . HOH D 4 .   ? 8.14400   -35.17500 -26.83400 1.000 33.95000  ? 644 HOH A O    1 
HETATM 3731 O O    . HOH D 4 .   ? 22.42500  -14.00300 12.10100  1.000 56.63000  ? 645 HOH A O    1 
HETATM 3732 O O    . HOH D 4 .   ? 6.11800   -31.59600 -20.75200 1.000 32.99000  ? 646 HOH A O    1 
HETATM 3733 O O    . HOH D 4 .   ? 11.76300  -16.72900 16.23100  1.000 36.36000  ? 647 HOH A O    1 
HETATM 3734 O O    . HOH D 4 .   ? 1.46000   -37.26800 -10.22800 1.000 37.03000  ? 648 HOH A O    1 
HETATM 3735 O O    . HOH D 4 .   ? 5.93500   -40.99700 8.67500   1.000 45.62000  ? 649 HOH A O    1 
HETATM 3736 O O    . HOH D 4 .   ? 17.93000  -50.05200 -3.19600  1.000 36.58000  ? 650 HOH A O    1 
HETATM 3737 O O    . HOH D 4 .   ? 35.47400  -28.84500 14.17300  1.000 41.41000  ? 651 HOH A O    1 
HETATM 3738 O O    . HOH D 4 .   ? 9.79600   -15.76600 14.51000  1.000 48.03000  ? 652 HOH A O    1 
HETATM 3739 O O    . HOH D 4 .   ? 25.09900  -19.76100 -3.74100  1.000 49.71000  ? 653 HOH A O    1 
HETATM 3740 O O    . HOH D 4 .   ? 7.41200   -37.19900 12.19100  1.000 49.15000  ? 654 HOH A O    1 
HETATM 3741 O O    . HOH D 4 .   ? 15.94600  -50.44700 -5.67700  1.000 33.23000  ? 655 HOH A O    1 
HETATM 3742 O O    . HOH D 4 .   ? 32.10300  -23.24800 13.39900  1.000 47.70000  ? 656 HOH A O    1 
HETATM 3743 O O    . HOH D 4 .   ? 13.25800  -13.01800 12.37000  1.000 54.80000  ? 657 HOH A O    1 
HETATM 3744 O O    . HOH D 4 .   ? 30.10100  -31.48800 18.23600  1.000 47.07000  ? 658 HOH A O    1 
HETATM 3745 O O    . HOH D 4 .   ? 2.97100   -38.58200 -26.26600 1.000 65.52000  ? 659 HOH A O    1 
HETATM 3746 O O    . HOH D 4 .   ? 7.08100   -41.63300 6.03200   1.000 29.52000  ? 660 HOH A O    1 
HETATM 3747 O O    . HOH D 4 .   ? 18.92000  -10.39600 5.75800   1.000 53.33000  ? 661 HOH A O    1 
HETATM 3748 O O    . HOH D 4 .   ? 1.905     -41.067   8.226     1.000 52.57000  ? 662 HOH A O    1 
HETATM 3749 O O    . HOH D 4 .   ? 13.58400  -51.41400 -5.81700  1.000 51.76000  ? 663 HOH A O    1 
HETATM 3750 O O    . HOH D 4 .   ? 10.78800  -13.83100 12.15700  1.000 53.97000  ? 664 HOH A O    1 
HETATM 3751 O O    . HOH D 4 .   ? 15.83000  -46.19600 12.59900  1.000 51.30000  ? 665 HOH A O    1 
HETATM 3752 O O    . HOH D 4 .   ? 18.72800  -8.93400  3.62400   1.000 50.12000  ? 666 HOH A O    1 
HETATM 3753 O O    . HOH D 4 .   ? 8.45900   -51.96300 -0.45200  1.000 41.54000  ? 667 HOH A O    1 
HETATM 3754 O O    . HOH D 4 .   ? 14.64200  -7.00400  4.06600   1.000 49.29000  ? 668 HOH A O    1 
HETATM 3755 O O    . HOH D 4 .   ? 0.47400   -32.72200 -17.63000 1.000 45.69000  ? 669 HOH A O    1 
HETATM 3756 O O    . HOH D 4 .   ? 17.04000  -45.16500 14.09500  1.000 56.43000  ? 670 HOH A O    1 
HETATM 3757 O O    . HOH D 4 .   ? 32.77700  -27.05600 14.19800  1.000 43.96000  ? 671 HOH A O    1 
HETATM 3758 O O    . HOH D 4 .   ? 2.85300   -19.33500 14.24400  1.000 47.82000  ? 672 HOH A O    1 
HETATM 3759 O O    . HOH D 4 .   ? 17.08300  -7.87500  -2.30000  1.000 59.21000  ? 673 HOH A O    1 
HETATM 3760 O O    . HOH D 4 .   ? 6.19500   -46.47800 7.69200   1.000 37.12000  ? 674 HOH A O    1 
HETATM 3761 O O    . HOH D 4 .   ? 7.32500   -43.60600 11.52300  1.000 58.19000  ? 675 HOH A O    1 
HETATM 3762 O O    . HOH D 4 .   ? 10.19900  -54.11300 -0.09100  1.000 67.65000  ? 676 HOH A O    1 
HETATM 3763 O O    . HOH D 4 .   ? 1.19500   -46.32100 5.68100   1.000 44.19000  ? 677 HOH A O    1 
HETATM 3764 O O    . HOH D 4 .   ? 3.43600   -32.47700 -20.93500 1.000 35.65000  ? 678 HOH A O    1 
HETATM 3765 O O    . HOH D 4 .   ? 15.04300  -8.36300  1.72600   1.000 32.79000  ? 679 HOH A O    1 
HETATM 3766 O O    . HOH D 4 .   ? 10.73000  -26.46700 -20.16900 1.000 44.92000  ? 680 HOH A O    1 
HETATM 3767 O O    . HOH D 4 .   ? 8.46900   -8.78700  3.28100   1.000 38.70000  ? 681 HOH A O    1 
HETATM 3768 O O    . HOH D 4 .   ? 20.99500  -38.79700 -11.13500 1.000 45.57000  ? 682 HOH A O    1 
HETATM 3769 O O    . HOH D 4 .   ? 7.24700   -33.29700 15.15300  1.000 46.87000  ? 683 HOH A O    1 
HETATM 3770 O O    . HOH D 4 .   ? 9.45100   -18.34300 17.42300  1.000 43.71000  ? 684 HOH A O    1 
HETATM 3771 O O    . HOH D 4 .   ? 16.93100  -7.27200  5.09600   1.000 51.39000  ? 685 HOH A O    1 
HETATM 3772 O O    . HOH D 4 .   ? 0.14500   -42.37300 -8.39300  1.000 54.78000  ? 686 HOH A O    1 
HETATM 3773 O O    . HOH D 4 .   ? 3.29900   -41.17300 -9.09500  1.000 33.13000  ? 687 HOH A O    1 
HETATM 3774 O O    . HOH D 4 .   ? 1.13300   -39.61000 -9.85800  1.000 49.28000  ? 688 HOH A O    1 
HETATM 3775 O O    . HOH D 4 .   ? -0.00000  -26.20600 0.00000   0.50  35.06000  ? 689 HOH A O    1 
HETATM 3776 O O    . HOH D 4 .   ? -1.03100  -37.13900 -9.22400  1.000 48.07000  ? 690 HOH A O    1 
HETATM 3777 O O    . HOH D 4 .   ? 15.58400  -6.84400  -0.50500  1.000 56.22000  ? 691 HOH A O    1 
# 
