data_9MSQ
# 
_entry.id   9MSQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MSQ         pdb_00009msq 10.2210/pdb9msq/pdb 
WWPDB D_1000291728 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-04 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MSQ 
_pdbx_database_status.recvd_initial_deposition_date   2025-01-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              redinbo@unc.edu 
_pdbx_contact_author.name_first         Matthew 
_pdbx_contact_author.name_last          Redinbo 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-0814-5346 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kowalewski, M.E.' 1 0000-0001-9455-7333 
'Redinbo, M.R.'    2 0000-0003-0814-5346 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochemistry 
_citation.journal_id_ASTM           BICHAW 
_citation.journal_id_CSD            0033 
_citation.journal_id_ISSN           0006-2960 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            64 
_citation.language                  ? 
_citation.page_first                2401 
_citation.page_last                 2411 
_citation.title                     'Structural Insights into Selectively Targeting Candida albicans Hsp90.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.biochem.5c00015 
_citation.pdbx_database_id_PubMed   40397669 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kowalewski, M.E.' 1 ? 
primary 'Zagler, S.'       2 ? 
primary 'Redinbo, M.R.'    3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Heat shock protein 90 homolog'                                                                                  
26350.838 1  ? ? ? ? 
2 non-polymer syn '(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one' 
379.388   1  ? ? ? ? 
3 water       nat water                                                                                                            
18.015    15 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKNLYFQSGSHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one' 990 
3 water                                                                                                            HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   ASP n 
1 4   ALA n 
1 5   LYS n 
1 6   VAL n 
1 7   GLU n 
1 8   THR n 
1 9   HIS n 
1 10  GLU n 
1 11  PHE n 
1 12  THR n 
1 13  ALA n 
1 14  GLU n 
1 15  ILE n 
1 16  SER n 
1 17  GLN n 
1 18  LEU n 
1 19  MET n 
1 20  SER n 
1 21  LEU n 
1 22  ILE n 
1 23  ILE n 
1 24  ASN n 
1 25  THR n 
1 26  VAL n 
1 27  TYR n 
1 28  SER n 
1 29  ASN n 
1 30  LYS n 
1 31  GLU n 
1 32  ILE n 
1 33  PHE n 
1 34  LEU n 
1 35  ARG n 
1 36  GLU n 
1 37  LEU n 
1 38  ILE n 
1 39  SER n 
1 40  ASN n 
1 41  ALA n 
1 42  SER n 
1 43  ASP n 
1 44  ALA n 
1 45  LEU n 
1 46  ASP n 
1 47  LYS n 
1 48  ILE n 
1 49  ARG n 
1 50  TYR n 
1 51  GLN n 
1 52  ALA n 
1 53  LEU n 
1 54  SER n 
1 55  ASP n 
1 56  PRO n 
1 57  SER n 
1 58  GLN n 
1 59  LEU n 
1 60  GLU n 
1 61  SER n 
1 62  GLU n 
1 63  PRO n 
1 64  GLU n 
1 65  LEU n 
1 66  PHE n 
1 67  ILE n 
1 68  ARG n 
1 69  ILE n 
1 70  ILE n 
1 71  PRO n 
1 72  GLN n 
1 73  LYS n 
1 74  ASP n 
1 75  GLN n 
1 76  LYS n 
1 77  VAL n 
1 78  LEU n 
1 79  GLU n 
1 80  ILE n 
1 81  ARG n 
1 82  ASP n 
1 83  SER n 
1 84  GLY n 
1 85  ILE n 
1 86  GLY n 
1 87  MET n 
1 88  THR n 
1 89  LYS n 
1 90  ALA n 
1 91  ASP n 
1 92  LEU n 
1 93  VAL n 
1 94  ASN n 
1 95  ASN n 
1 96  LEU n 
1 97  GLY n 
1 98  THR n 
1 99  ILE n 
1 100 ALA n 
1 101 LYS n 
1 102 SER n 
1 103 GLY n 
1 104 THR n 
1 105 LYS n 
1 106 SER n 
1 107 PHE n 
1 108 MET n 
1 109 GLU n 
1 110 ALA n 
1 111 LEU n 
1 112 SER n 
1 113 ALA n 
1 114 GLY n 
1 115 ALA n 
1 116 ASP n 
1 117 VAL n 
1 118 SER n 
1 119 MET n 
1 120 ILE n 
1 121 GLY n 
1 122 GLN n 
1 123 PHE n 
1 124 GLY n 
1 125 VAL n 
1 126 GLY n 
1 127 PHE n 
1 128 TYR n 
1 129 SER n 
1 130 LEU n 
1 131 PHE n 
1 132 LEU n 
1 133 VAL n 
1 134 ALA n 
1 135 ASP n 
1 136 HIS n 
1 137 VAL n 
1 138 GLN n 
1 139 VAL n 
1 140 ILE n 
1 141 SER n 
1 142 LYS n 
1 143 HIS n 
1 144 ASN n 
1 145 ASP n 
1 146 ASP n 
1 147 GLU n 
1 148 GLN n 
1 149 TYR n 
1 150 VAL n 
1 151 TRP n 
1 152 GLU n 
1 153 SER n 
1 154 ASN n 
1 155 ALA n 
1 156 GLY n 
1 157 GLY n 
1 158 LYS n 
1 159 PHE n 
1 160 THR n 
1 161 VAL n 
1 162 THR n 
1 163 LEU n 
1 164 ASP n 
1 165 GLU n 
1 166 THR n 
1 167 ASN n 
1 168 GLU n 
1 169 ARG n 
1 170 LEU n 
1 171 GLY n 
1 172 ARG n 
1 173 GLY n 
1 174 THR n 
1 175 MET n 
1 176 LEU n 
1 177 ARG n 
1 178 LEU n 
1 179 PHE n 
1 180 LEU n 
1 181 LYS n 
1 182 GLU n 
1 183 ASP n 
1 184 GLN n 
1 185 LEU n 
1 186 GLU n 
1 187 TYR n 
1 188 LEU n 
1 189 GLU n 
1 190 GLU n 
1 191 LYS n 
1 192 ARG n 
1 193 ILE n 
1 194 LYS n 
1 195 GLU n 
1 196 VAL n 
1 197 VAL n 
1 198 LYS n 
1 199 LYS n 
1 200 HIS n 
1 201 SER n 
1 202 GLU n 
1 203 PHE n 
1 204 VAL n 
1 205 ALA n 
1 206 TYR n 
1 207 PRO n 
1 208 ILE n 
1 209 GLN n 
1 210 LEU n 
1 211 VAL n 
1 212 VAL n 
1 213 THR n 
1 214 LYS n 
1 215 GLU n 
1 216 VAL n 
1 217 GLU n 
1 218 LYS n 
1 219 ASN n 
1 220 LEU n 
1 221 TYR n 
1 222 PHE n 
1 223 GLN n 
1 224 SER n 
1 225 GLY n 
1 226 SER n 
1 227 HIS n 
1 228 HIS n 
1 229 HIS n 
1 230 HIS n 
1 231 HIS n 
1 232 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   232 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'HSP90, CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Candida albicans' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     5476 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
990 non-polymer         . 
'(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one' ? 
'C20 H18 F N5 O2' 379.388 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   ASP 3   3   ?   ?   ?   A . n 
A 1 4   ALA 4   4   4   ALA ALA A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   VAL 6   6   6   VAL VAL A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   THR 8   8   8   THR THR A . n 
A 1 9   HIS 9   9   9   HIS HIS A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  PHE 11  11  11  PHE PHE A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  ALA 13  13  13  ALA ALA A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  ILE 15  15  15  ILE ILE A . n 
A 1 16  SER 16  16  16  SER SER A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  MET 19  19  19  MET MET A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  ILE 22  22  22  ILE ILE A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  ASN 24  24  24  ASN ASN A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  VAL 26  26  26  VAL VAL A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  LYS 30  30  30  LYS LYS A . n 
A 1 31  GLU 31  31  31  GLU GLU A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  PHE 33  33  33  PHE PHE A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  GLU 36  36  36  GLU GLU A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  SER 39  39  39  SER SER A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  ASP 43  43  43  ASP ASP A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  ASP 46  46  46  ASP ASP A . n 
A 1 47  LYS 47  47  47  LYS LYS A . n 
A 1 48  ILE 48  48  48  ILE ILE A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  TYR 50  50  50  TYR TYR A . n 
A 1 51  GLN 51  51  51  GLN GLN A . n 
A 1 52  ALA 52  52  52  ALA ALA A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  PRO 56  56  56  PRO PRO A . n 
A 1 57  SER 57  57  57  SER SER A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  GLU 60  60  60  GLU GLU A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  ILE 67  67  67  ILE ILE A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  ILE 69  69  69  ILE ILE A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  PRO 71  71  71  PRO PRO A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  GLN 75  75  75  GLN GLN A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  GLU 79  79  79  GLU GLU A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ARG 81  81  81  ARG ARG A . n 
A 1 82  ASP 82  82  82  ASP ASP A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  GLY 86  86  86  GLY GLY A . n 
A 1 87  MET 87  87  87  MET MET A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  ASP 91  91  91  ASP ASP A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  LEU 96  96  ?   ?   ?   A . n 
A 1 97  GLY 97  97  ?   ?   ?   A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 ALA 100 100 100 ALA ALA A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 LYS 105 105 105 LYS LYS A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 PHE 107 107 107 PHE PHE A . n 
A 1 108 MET 108 108 108 MET MET A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 GLY 114 114 114 GLY GLY A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 SER 118 118 118 SER SER A . n 
A 1 119 MET 119 119 119 MET MET A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLN 122 122 122 GLN GLN A . n 
A 1 123 PHE 123 123 123 PHE PHE A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 PHE 127 127 127 PHE PHE A . n 
A 1 128 TYR 128 128 128 TYR TYR A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 PHE 131 131 131 PHE PHE A . n 
A 1 132 LEU 132 132 132 LEU LEU A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 HIS 136 136 136 HIS HIS A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 VAL 139 139 139 VAL VAL A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 SER 141 141 141 SER SER A . n 
A 1 142 LYS 142 142 142 LYS LYS A . n 
A 1 143 HIS 143 143 143 HIS HIS A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 GLU 147 147 147 GLU GLU A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 TRP 151 151 151 TRP TRP A . n 
A 1 152 GLU 152 152 152 GLU GLU A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 GLY 156 156 156 GLY GLY A . n 
A 1 157 GLY 157 157 157 GLY GLY A . n 
A 1 158 LYS 158 158 158 LYS LYS A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 VAL 161 161 161 VAL VAL A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 GLU 165 165 165 GLU GLU A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 ASN 167 167 167 ASN ASN A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 GLY 171 171 171 GLY GLY A . n 
A 1 172 ARG 172 172 172 ARG ARG A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 MET 175 175 175 MET MET A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 LEU 178 178 178 LEU LEU A . n 
A 1 179 PHE 179 179 179 PHE PHE A . n 
A 1 180 LEU 180 180 180 LEU LEU A . n 
A 1 181 LYS 181 181 181 LYS LYS A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 GLN 184 184 184 GLN GLN A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 GLU 186 186 186 GLU GLU A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 LYS 194 194 194 LYS LYS A . n 
A 1 195 GLU 195 195 195 GLU GLU A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 LYS 198 198 198 LYS LYS A . n 
A 1 199 LYS 199 199 199 LYS LYS A . n 
A 1 200 HIS 200 200 200 HIS HIS A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 GLU 202 202 202 GLU GLU A . n 
A 1 203 PHE 203 203 203 PHE PHE A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 PRO 207 207 207 PRO PRO A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 GLN 209 209 209 GLN GLN A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 GLU 215 215 215 GLU GLU A . n 
A 1 216 VAL 216 216 216 VAL VAL A . n 
A 1 217 GLU 217 217 217 GLU GLU A . n 
A 1 218 LYS 218 218 ?   ?   ?   A . n 
A 1 219 ASN 219 219 ?   ?   ?   A . n 
A 1 220 LEU 220 220 ?   ?   ?   A . n 
A 1 221 TYR 221 221 ?   ?   ?   A . n 
A 1 222 PHE 222 222 ?   ?   ?   A . n 
A 1 223 GLN 223 223 ?   ?   ?   A . n 
A 1 224 SER 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 SER 226 226 ?   ?   ?   A . n 
A 1 227 HIS 227 227 ?   ?   ?   A . n 
A 1 228 HIS 228 228 ?   ?   ?   A . n 
A 1 229 HIS 229 229 ?   ?   ?   A . n 
A 1 230 HIS 230 230 ?   ?   ?   A . n 
A 1 231 HIS 231 231 ?   ?   ?   A . n 
A 1 232 HIS 232 232 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        990 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   990 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 990 1  301 301 990 990 A . 
C 3 HOH 1  401 3   HOH HOH A . 
C 3 HOH 2  402 1   HOH HOH A . 
C 3 HOH 3  403 8   HOH HOH A . 
C 3 HOH 4  404 4   HOH HOH A . 
C 3 HOH 5  405 6   HOH HOH A . 
C 3 HOH 6  406 12  HOH HOH A . 
C 3 HOH 7  407 14  HOH HOH A . 
C 3 HOH 8  408 5   HOH HOH A . 
C 3 HOH 9  409 11  HOH HOH A . 
C 3 HOH 10 410 9   HOH HOH A . 
C 3 HOH 11 411 17  HOH HOH A . 
C 3 HOH 12 412 10  HOH HOH A . 
C 3 HOH 13 413 2   HOH HOH A . 
C 3 HOH 14 414 16  HOH HOH A . 
C 3 HOH 15 415 15  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 5   ? CG  ? A LYS 5   CG  
2  1 Y 1 A LYS 5   ? CD  ? A LYS 5   CD  
3  1 Y 1 A LYS 5   ? CE  ? A LYS 5   CE  
4  1 Y 1 A LYS 5   ? NZ  ? A LYS 5   NZ  
5  1 Y 1 A GLN 17  ? CG  ? A GLN 17  CG  
6  1 Y 1 A GLN 17  ? CD  ? A GLN 17  CD  
7  1 Y 1 A GLN 17  ? OE1 ? A GLN 17  OE1 
8  1 Y 1 A GLN 17  ? NE2 ? A GLN 17  NE2 
9  1 Y 1 A LYS 101 ? CG  ? A LYS 101 CG  
10 1 Y 1 A LYS 101 ? CD  ? A LYS 101 CD  
11 1 Y 1 A LYS 101 ? CE  ? A LYS 101 CE  
12 1 Y 1 A LYS 101 ? NZ  ? A LYS 101 NZ  
13 1 Y 1 A LYS 214 ? CG  ? A LYS 214 CG  
14 1 Y 1 A LYS 214 ? CD  ? A LYS 214 CD  
15 1 Y 1 A LYS 214 ? CE  ? A LYS 214 CE  
16 1 Y 1 A LYS 214 ? NZ  ? A LYS 214 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.1_5286 1 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           2 
? 'data processing' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless  ? ? ? .           4 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS      ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MSQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     73.758 
_cell.length_a_esd                 ? 
_cell.length_b                     73.758 
_cell.length_b_esd                 ? 
_cell.length_c                     107.014 
_cell.length_c_esd                 ? 
_cell.volume                       582182.118 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MSQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                95 
_symmetry.space_group_name_Hall            'P 4cw 2c' 
_symmetry.space_group_name_H-M             'P 43 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MSQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.76 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.46 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.17 M ammonium acetate, 0.085 M sodium citrate:HCl pH 5.6, 25.5% w/v PEG4000, and 15% glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          54.61 
_reflns.entry_id                                       9MSQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.53 
_reflns.d_resolution_low                               37.35 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10390 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.95 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          21.66 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              .08814 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.53 
_reflns_shell.d_res_low                                     2.66 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.83 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1437 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               19.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.955 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.93 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.6209 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               60.76 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MSQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.53 
_refine.ls_d_res_low                             37.35 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10386 
_refine.ls_number_reflns_R_free                  1039 
_refine.ls_number_reflns_R_work                  9347 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.96 
_refine.ls_percent_reflns_R_free                 10.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2166 
_refine.ls_R_factor_R_free                       0.2663 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2111 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.0369 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3584 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.53 
_refine_hist.d_res_low                        37.35 
_refine_hist.number_atoms_solvent             15 
_refine_hist.number_atoms_total               1714 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1671 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         28 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0158  ? 1735 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.5549  ? 2345 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0714  ? 268  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0132  ? 300  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 21.4253 ? 651  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.53 2.66  . . 144 1293 100.00 . . . . 0.2562 . . . . . . . . . . . . . . . 0.3106 
'X-RAY DIFFRACTION' 2.66 2.83  . . 144 1305 100.00 . . . . 0.2666 . . . . . . . . . . . . . . . 0.3429 
'X-RAY DIFFRACTION' 2.83 3.05  . . 146 1310 100.00 . . . . 0.2616 . . . . . . . . . . . . . . . 0.3673 
'X-RAY DIFFRACTION' 3.05 3.36  . . 146 1310 99.86  . . . . 0.2381 . . . . . . . . . . . . . . . 0.2804 
'X-RAY DIFFRACTION' 3.36 3.84  . . 149 1336 100.00 . . . . 0.2197 . . . . . . . . . . . . . . . 0.2735 
'X-RAY DIFFRACTION' 3.84 4.84  . . 149 1345 100.00 . . . . 0.1711 . . . . . . . . . . . . . . . 0.2287 
'X-RAY DIFFRACTION' 4.84 37.35 . . 161 1448 99.88  . . . . 0.1994 . . . . . . . . . . . . . . . 0.2416 
# 
_struct.entry_id                     9MSQ 
_struct.title                        'Candida albicans Hsp90 nucleotide binding domain in complex with HSP990' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MSQ 
_struct_keywords.text            'Inhibitor complex, CHAPERONE, CHAPERONE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   CHAPERONE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    HSP90_CANAL 
_struct_ref.pdbx_db_accession          P46598 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEI
RDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFT
VTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEK
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MSQ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 218 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P46598 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  218 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       218 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MSQ ASN A 219 ? UNP P46598 ? ? 'expression tag' 219 1  
1 9MSQ LEU A 220 ? UNP P46598 ? ? 'expression tag' 220 2  
1 9MSQ TYR A 221 ? UNP P46598 ? ? 'expression tag' 221 3  
1 9MSQ PHE A 222 ? UNP P46598 ? ? 'expression tag' 222 4  
1 9MSQ GLN A 223 ? UNP P46598 ? ? 'expression tag' 223 5  
1 9MSQ SER A 224 ? UNP P46598 ? ? 'expression tag' 224 6  
1 9MSQ GLY A 225 ? UNP P46598 ? ? 'expression tag' 225 7  
1 9MSQ SER A 226 ? UNP P46598 ? ? 'expression tag' 226 8  
1 9MSQ HIS A 227 ? UNP P46598 ? ? 'expression tag' 227 9  
1 9MSQ HIS A 228 ? UNP P46598 ? ? 'expression tag' 228 10 
1 9MSQ HIS A 229 ? UNP P46598 ? ? 'expression tag' 229 11 
1 9MSQ HIS A 230 ? UNP P46598 ? ? 'expression tag' 230 12 
1 9MSQ HIS A 231 ? UNP P46598 ? ? 'expression tag' 231 13 
1 9MSQ HIS A 232 ? UNP P46598 ? ? 'expression tag' 232 14 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 12  ? THR A 25  ? THR A 12  THR A 25  1 ? 14 
HELX_P HELX_P2 AA2 GLU A 31  ? ASP A 55  ? GLU A 31  ASP A 55  1 ? 25 
HELX_P HELX_P3 AA3 PRO A 56  ? GLU A 62  ? PRO A 56  GLU A 62  5 ? 7  
HELX_P HELX_P4 AA4 THR A 88  ? ASN A 94  ? THR A 88  ASN A 94  1 ? 7  
HELX_P HELX_P5 AA5 ILE A 99  ? ALA A 113 ? ILE A 99  ALA A 113 1 ? 15 
HELX_P HELX_P6 AA6 ASP A 116 ? GLY A 124 ? ASP A 116 GLY A 124 5 ? 9  
HELX_P HELX_P7 AA7 VAL A 125 ? LEU A 132 ? VAL A 125 LEU A 132 5 ? 8  
HELX_P HELX_P8 AA8 GLU A 182 ? LEU A 188 ? GLU A 182 LEU A 188 5 ? 7  
HELX_P HELX_P9 AA9 GLU A 189 ? SER A 201 ? GLU A 189 SER A 201 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   8 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 7   ? GLU A 10  ? GLU A 7   GLU A 10  
AA1 2 LYS A 158 ? LEU A 163 ? LYS A 158 LEU A 163 
AA1 3 GLN A 148 ? SER A 153 ? GLN A 148 SER A 153 
AA1 4 ALA A 134 ? LYS A 142 ? ALA A 134 LYS A 142 
AA1 5 GLY A 173 ? LEU A 180 ? GLY A 173 LEU A 180 
AA1 6 VAL A 77  ? ASP A 82  ? VAL A 77  ASP A 82  
AA1 7 ILE A 67  ? GLN A 72  ? ILE A 67  GLN A 72  
AA1 8 ILE A 208 ? LEU A 210 ? ILE A 208 LEU A 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 9   ? N HIS A 9   O PHE A 159 ? O PHE A 159 
AA1 2 3 O THR A 162 ? O THR A 162 N VAL A 150 ? N VAL A 150 
AA1 3 4 O TRP A 151 ? O TRP A 151 N VAL A 139 ? N VAL A 139 
AA1 4 5 N GLN A 138 ? N GLN A 138 O ARG A 177 ? O ARG A 177 
AA1 5 6 O LEU A 178 ? O LEU A 178 N LEU A 78  ? N LEU A 78  
AA1 6 7 O ARG A 81  ? O ARG A 81  N ARG A 68  ? N ARG A 68  
AA1 7 8 N ILE A 69  ? N ILE A 69  O GLN A 209 ? O GLN A 209 
# 
_pdbx_entry_details.entry_id                   9MSQ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 27  ? ? -31.74  137.81 
2 1 GLU A 31  ? ? -55.30  -7.68  
3 1 GLU A 62  ? ? -169.38 83.81  
4 1 SER A 83  ? ? -99.67  43.88  
5 1 ASN A 94  ? ? -155.22 47.20  
6 1 ALA A 155 ? ? 80.94   8.52   
7 1 SER A 201 ? ? -140.50 50.00  
8 1 PHE A 203 ? ? -105.11 57.95  
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     192 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.081 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z        
2 -y,x,z+3/4   
3 y,-x,z+1/4   
4 x,-y,-z+1/2  
5 -x,y,-z      
6 -x,-y,z+1/2  
7 y,x,-z+1/4   
8 -y,-x,-z+3/4 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A ASP 3   ? A ASP 3   
4  1 Y 1 A LEU 96  ? A LEU 96  
5  1 Y 1 A GLY 97  ? A GLY 97  
6  1 Y 1 A LYS 218 ? A LYS 218 
7  1 Y 1 A ASN 219 ? A ASN 219 
8  1 Y 1 A LEU 220 ? A LEU 220 
9  1 Y 1 A TYR 221 ? A TYR 221 
10 1 Y 1 A PHE 222 ? A PHE 222 
11 1 Y 1 A GLN 223 ? A GLN 223 
12 1 Y 1 A SER 224 ? A SER 224 
13 1 Y 1 A GLY 225 ? A GLY 225 
14 1 Y 1 A SER 226 ? A SER 226 
15 1 Y 1 A HIS 227 ? A HIS 227 
16 1 Y 1 A HIS 228 ? A HIS 228 
17 1 Y 1 A HIS 229 ? A HIS 229 
18 1 Y 1 A HIS 230 ? A HIS 230 
19 1 Y 1 A HIS 231 ? A HIS 231 
20 1 Y 1 A HIS 232 ? A HIS 232 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
990 F17  F N N 1   
990 C16  C Y N 2   
990 C18  C Y N 3   
990 C8   C Y N 4   
990 C21  C Y N 5   
990 N26  N Y N 6   
990 C25  C Y N 7   
990 O27  O N N 8   
990 C28  C N N 9   
990 C24  C Y N 10  
990 C23  C Y N 11  
990 C22  C Y N 12  
990 C19  C Y N 13  
990 C20  C Y N 14  
990 C7   C Y N 15  
990 C6   C N R 16  
990 N9   N N N 17  
990 C1   C N N 18  
990 O2   O N N 19  
990 C5   C N N 20  
990 C4   C Y N 21  
990 N15  N Y N 22  
990 C13  C Y N 23  
990 N14  N N N 24  
990 N12  N Y N 25  
990 C10  C Y N 26  
990 C3   C Y N 27  
990 C11  C N N 28  
990 H1   H N N 29  
990 H2   H N N 30  
990 H3   H N N 31  
990 H4   H N N 32  
990 H5   H N N 33  
990 H6   H N N 34  
990 H7   H N N 35  
990 H8   H N N 36  
990 H9   H N N 37  
990 H10  H N N 38  
990 H11  H N N 39  
990 H12  H N N 40  
990 H13  H N N 41  
990 H14  H N N 42  
990 H15  H N N 43  
990 H16  H N N 44  
990 H17  H N N 45  
990 H18  H N N 46  
ALA N    N N N 47  
ALA CA   C N S 48  
ALA C    C N N 49  
ALA O    O N N 50  
ALA CB   C N N 51  
ALA OXT  O N N 52  
ALA H    H N N 53  
ALA H2   H N N 54  
ALA HA   H N N 55  
ALA HB1  H N N 56  
ALA HB2  H N N 57  
ALA HB3  H N N 58  
ALA HXT  H N N 59  
ARG N    N N N 60  
ARG CA   C N S 61  
ARG C    C N N 62  
ARG O    O N N 63  
ARG CB   C N N 64  
ARG CG   C N N 65  
ARG CD   C N N 66  
ARG NE   N N N 67  
ARG CZ   C N N 68  
ARG NH1  N N N 69  
ARG NH2  N N N 70  
ARG OXT  O N N 71  
ARG H    H N N 72  
ARG H2   H N N 73  
ARG HA   H N N 74  
ARG HB2  H N N 75  
ARG HB3  H N N 76  
ARG HG2  H N N 77  
ARG HG3  H N N 78  
ARG HD2  H N N 79  
ARG HD3  H N N 80  
ARG HE   H N N 81  
ARG HH11 H N N 82  
ARG HH12 H N N 83  
ARG HH21 H N N 84  
ARG HH22 H N N 85  
ARG HXT  H N N 86  
ASN N    N N N 87  
ASN CA   C N S 88  
ASN C    C N N 89  
ASN O    O N N 90  
ASN CB   C N N 91  
ASN CG   C N N 92  
ASN OD1  O N N 93  
ASN ND2  N N N 94  
ASN OXT  O N N 95  
ASN H    H N N 96  
ASN H2   H N N 97  
ASN HA   H N N 98  
ASN HB2  H N N 99  
ASN HB3  H N N 100 
ASN HD21 H N N 101 
ASN HD22 H N N 102 
ASN HXT  H N N 103 
ASP N    N N N 104 
ASP CA   C N S 105 
ASP C    C N N 106 
ASP O    O N N 107 
ASP CB   C N N 108 
ASP CG   C N N 109 
ASP OD1  O N N 110 
ASP OD2  O N N 111 
ASP OXT  O N N 112 
ASP H    H N N 113 
ASP H2   H N N 114 
ASP HA   H N N 115 
ASP HB2  H N N 116 
ASP HB3  H N N 117 
ASP HD2  H N N 118 
ASP HXT  H N N 119 
GLN N    N N N 120 
GLN CA   C N S 121 
GLN C    C N N 122 
GLN O    O N N 123 
GLN CB   C N N 124 
GLN CG   C N N 125 
GLN CD   C N N 126 
GLN OE1  O N N 127 
GLN NE2  N N N 128 
GLN OXT  O N N 129 
GLN H    H N N 130 
GLN H2   H N N 131 
GLN HA   H N N 132 
GLN HB2  H N N 133 
GLN HB3  H N N 134 
GLN HG2  H N N 135 
GLN HG3  H N N 136 
GLN HE21 H N N 137 
GLN HE22 H N N 138 
GLN HXT  H N N 139 
GLU N    N N N 140 
GLU CA   C N S 141 
GLU C    C N N 142 
GLU O    O N N 143 
GLU CB   C N N 144 
GLU CG   C N N 145 
GLU CD   C N N 146 
GLU OE1  O N N 147 
GLU OE2  O N N 148 
GLU OXT  O N N 149 
GLU H    H N N 150 
GLU H2   H N N 151 
GLU HA   H N N 152 
GLU HB2  H N N 153 
GLU HB3  H N N 154 
GLU HG2  H N N 155 
GLU HG3  H N N 156 
GLU HE2  H N N 157 
GLU HXT  H N N 158 
GLY N    N N N 159 
GLY CA   C N N 160 
GLY C    C N N 161 
GLY O    O N N 162 
GLY OXT  O N N 163 
GLY H    H N N 164 
GLY H2   H N N 165 
GLY HA2  H N N 166 
GLY HA3  H N N 167 
GLY HXT  H N N 168 
HIS N    N N N 169 
HIS CA   C N S 170 
HIS C    C N N 171 
HIS O    O N N 172 
HIS CB   C N N 173 
HIS CG   C Y N 174 
HIS ND1  N Y N 175 
HIS CD2  C Y N 176 
HIS CE1  C Y N 177 
HIS NE2  N Y N 178 
HIS OXT  O N N 179 
HIS H    H N N 180 
HIS H2   H N N 181 
HIS HA   H N N 182 
HIS HB2  H N N 183 
HIS HB3  H N N 184 
HIS HD1  H N N 185 
HIS HD2  H N N 186 
HIS HE1  H N N 187 
HIS HE2  H N N 188 
HIS HXT  H N N 189 
HOH O    O N N 190 
HOH H1   H N N 191 
HOH H2   H N N 192 
ILE N    N N N 193 
ILE CA   C N S 194 
ILE C    C N N 195 
ILE O    O N N 196 
ILE CB   C N S 197 
ILE CG1  C N N 198 
ILE CG2  C N N 199 
ILE CD1  C N N 200 
ILE OXT  O N N 201 
ILE H    H N N 202 
ILE H2   H N N 203 
ILE HA   H N N 204 
ILE HB   H N N 205 
ILE HG12 H N N 206 
ILE HG13 H N N 207 
ILE HG21 H N N 208 
ILE HG22 H N N 209 
ILE HG23 H N N 210 
ILE HD11 H N N 211 
ILE HD12 H N N 212 
ILE HD13 H N N 213 
ILE HXT  H N N 214 
LEU N    N N N 215 
LEU CA   C N S 216 
LEU C    C N N 217 
LEU O    O N N 218 
LEU CB   C N N 219 
LEU CG   C N N 220 
LEU CD1  C N N 221 
LEU CD2  C N N 222 
LEU OXT  O N N 223 
LEU H    H N N 224 
LEU H2   H N N 225 
LEU HA   H N N 226 
LEU HB2  H N N 227 
LEU HB3  H N N 228 
LEU HG   H N N 229 
LEU HD11 H N N 230 
LEU HD12 H N N 231 
LEU HD13 H N N 232 
LEU HD21 H N N 233 
LEU HD22 H N N 234 
LEU HD23 H N N 235 
LEU HXT  H N N 236 
LYS N    N N N 237 
LYS CA   C N S 238 
LYS C    C N N 239 
LYS O    O N N 240 
LYS CB   C N N 241 
LYS CG   C N N 242 
LYS CD   C N N 243 
LYS CE   C N N 244 
LYS NZ   N N N 245 
LYS OXT  O N N 246 
LYS H    H N N 247 
LYS H2   H N N 248 
LYS HA   H N N 249 
LYS HB2  H N N 250 
LYS HB3  H N N 251 
LYS HG2  H N N 252 
LYS HG3  H N N 253 
LYS HD2  H N N 254 
LYS HD3  H N N 255 
LYS HE2  H N N 256 
LYS HE3  H N N 257 
LYS HZ1  H N N 258 
LYS HZ2  H N N 259 
LYS HZ3  H N N 260 
LYS HXT  H N N 261 
MET N    N N N 262 
MET CA   C N S 263 
MET C    C N N 264 
MET O    O N N 265 
MET CB   C N N 266 
MET CG   C N N 267 
MET SD   S N N 268 
MET CE   C N N 269 
MET OXT  O N N 270 
MET H    H N N 271 
MET H2   H N N 272 
MET HA   H N N 273 
MET HB2  H N N 274 
MET HB3  H N N 275 
MET HG2  H N N 276 
MET HG3  H N N 277 
MET HE1  H N N 278 
MET HE2  H N N 279 
MET HE3  H N N 280 
MET HXT  H N N 281 
PHE N    N N N 282 
PHE CA   C N S 283 
PHE C    C N N 284 
PHE O    O N N 285 
PHE CB   C N N 286 
PHE CG   C Y N 287 
PHE CD1  C Y N 288 
PHE CD2  C Y N 289 
PHE CE1  C Y N 290 
PHE CE2  C Y N 291 
PHE CZ   C Y N 292 
PHE OXT  O N N 293 
PHE H    H N N 294 
PHE H2   H N N 295 
PHE HA   H N N 296 
PHE HB2  H N N 297 
PHE HB3  H N N 298 
PHE HD1  H N N 299 
PHE HD2  H N N 300 
PHE HE1  H N N 301 
PHE HE2  H N N 302 
PHE HZ   H N N 303 
PHE HXT  H N N 304 
PRO N    N N N 305 
PRO CA   C N S 306 
PRO C    C N N 307 
PRO O    O N N 308 
PRO CB   C N N 309 
PRO CG   C N N 310 
PRO CD   C N N 311 
PRO OXT  O N N 312 
PRO H    H N N 313 
PRO HA   H N N 314 
PRO HB2  H N N 315 
PRO HB3  H N N 316 
PRO HG2  H N N 317 
PRO HG3  H N N 318 
PRO HD2  H N N 319 
PRO HD3  H N N 320 
PRO HXT  H N N 321 
SER N    N N N 322 
SER CA   C N S 323 
SER C    C N N 324 
SER O    O N N 325 
SER CB   C N N 326 
SER OG   O N N 327 
SER OXT  O N N 328 
SER H    H N N 329 
SER H2   H N N 330 
SER HA   H N N 331 
SER HB2  H N N 332 
SER HB3  H N N 333 
SER HG   H N N 334 
SER HXT  H N N 335 
THR N    N N N 336 
THR CA   C N S 337 
THR C    C N N 338 
THR O    O N N 339 
THR CB   C N R 340 
THR OG1  O N N 341 
THR CG2  C N N 342 
THR OXT  O N N 343 
THR H    H N N 344 
THR H2   H N N 345 
THR HA   H N N 346 
THR HB   H N N 347 
THR HG1  H N N 348 
THR HG21 H N N 349 
THR HG22 H N N 350 
THR HG23 H N N 351 
THR HXT  H N N 352 
TRP N    N N N 353 
TRP CA   C N S 354 
TRP C    C N N 355 
TRP O    O N N 356 
TRP CB   C N N 357 
TRP CG   C Y N 358 
TRP CD1  C Y N 359 
TRP CD2  C Y N 360 
TRP NE1  N Y N 361 
TRP CE2  C Y N 362 
TRP CE3  C Y N 363 
TRP CZ2  C Y N 364 
TRP CZ3  C Y N 365 
TRP CH2  C Y N 366 
TRP OXT  O N N 367 
TRP H    H N N 368 
TRP H2   H N N 369 
TRP HA   H N N 370 
TRP HB2  H N N 371 
TRP HB3  H N N 372 
TRP HD1  H N N 373 
TRP HE1  H N N 374 
TRP HE3  H N N 375 
TRP HZ2  H N N 376 
TRP HZ3  H N N 377 
TRP HH2  H N N 378 
TRP HXT  H N N 379 
TYR N    N N N 380 
TYR CA   C N S 381 
TYR C    C N N 382 
TYR O    O N N 383 
TYR CB   C N N 384 
TYR CG   C Y N 385 
TYR CD1  C Y N 386 
TYR CD2  C Y N 387 
TYR CE1  C Y N 388 
TYR CE2  C Y N 389 
TYR CZ   C Y N 390 
TYR OH   O N N 391 
TYR OXT  O N N 392 
TYR H    H N N 393 
TYR H2   H N N 394 
TYR HA   H N N 395 
TYR HB2  H N N 396 
TYR HB3  H N N 397 
TYR HD1  H N N 398 
TYR HD2  H N N 399 
TYR HE1  H N N 400 
TYR HE2  H N N 401 
TYR HH   H N N 402 
TYR HXT  H N N 403 
VAL N    N N N 404 
VAL CA   C N S 405 
VAL C    C N N 406 
VAL O    O N N 407 
VAL CB   C N N 408 
VAL CG1  C N N 409 
VAL CG2  C N N 410 
VAL OXT  O N N 411 
VAL H    H N N 412 
VAL H2   H N N 413 
VAL HA   H N N 414 
VAL HB   H N N 415 
VAL HG11 H N N 416 
VAL HG12 H N N 417 
VAL HG13 H N N 418 
VAL HG21 H N N 419 
VAL HG22 H N N 420 
VAL HG23 H N N 421 
VAL HXT  H N N 422 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
990 O2  C1   doub N N 1   
990 C19 C20  doub Y N 2   
990 C19 C16  sing Y N 3   
990 C20 C7   sing Y N 4   
990 C1  N9   sing N N 5   
990 C1  C3   sing N N 6   
990 C11 C10  sing N N 7   
990 N9  C6   sing N N 8   
990 F17 C16  sing N N 9   
990 C10 C3   doub Y N 10  
990 C10 N12  sing Y N 11  
990 C3  C4   sing Y N 12  
990 C16 C18  doub Y N 13  
990 C7  C6   sing N N 14  
990 C7  C8   doub Y N 15  
990 N12 C13  doub Y N 16  
990 C4  C5   sing N N 17  
990 C4  N15  doub Y N 18  
990 C5  C6   sing N N 19  
990 C13 N15  sing Y N 20  
990 C13 N14  sing N N 21  
990 C18 C8   sing Y N 22  
990 C8  C21  sing N N 23  
990 C21 N26  doub Y N 24  
990 C21 C22  sing Y N 25  
990 N26 C25  sing Y N 26  
990 C22 C23  doub Y N 27  
990 C28 O27  sing N N 28  
990 C25 O27  sing N N 29  
990 C25 C24  doub Y N 30  
990 C23 C24  sing Y N 31  
990 C18 H1   sing N N 32  
990 C28 H2   sing N N 33  
990 C28 H3   sing N N 34  
990 C28 H4   sing N N 35  
990 C24 H5   sing N N 36  
990 C23 H6   sing N N 37  
990 C22 H7   sing N N 38  
990 C19 H8   sing N N 39  
990 C20 H9   sing N N 40  
990 C6  H10  sing N N 41  
990 N9  H11  sing N N 42  
990 C5  H12  sing N N 43  
990 C5  H13  sing N N 44  
990 N14 H14  sing N N 45  
990 N14 H15  sing N N 46  
990 C11 H16  sing N N 47  
990 C11 H17  sing N N 48  
990 C11 H18  sing N N 49  
ALA N   CA   sing N N 50  
ALA N   H    sing N N 51  
ALA N   H2   sing N N 52  
ALA CA  C    sing N N 53  
ALA CA  CB   sing N N 54  
ALA CA  HA   sing N N 55  
ALA C   O    doub N N 56  
ALA C   OXT  sing N N 57  
ALA CB  HB1  sing N N 58  
ALA CB  HB2  sing N N 59  
ALA CB  HB3  sing N N 60  
ALA OXT HXT  sing N N 61  
ARG N   CA   sing N N 62  
ARG N   H    sing N N 63  
ARG N   H2   sing N N 64  
ARG CA  C    sing N N 65  
ARG CA  CB   sing N N 66  
ARG CA  HA   sing N N 67  
ARG C   O    doub N N 68  
ARG C   OXT  sing N N 69  
ARG CB  CG   sing N N 70  
ARG CB  HB2  sing N N 71  
ARG CB  HB3  sing N N 72  
ARG CG  CD   sing N N 73  
ARG CG  HG2  sing N N 74  
ARG CG  HG3  sing N N 75  
ARG CD  NE   sing N N 76  
ARG CD  HD2  sing N N 77  
ARG CD  HD3  sing N N 78  
ARG NE  CZ   sing N N 79  
ARG NE  HE   sing N N 80  
ARG CZ  NH1  sing N N 81  
ARG CZ  NH2  doub N N 82  
ARG NH1 HH11 sing N N 83  
ARG NH1 HH12 sing N N 84  
ARG NH2 HH21 sing N N 85  
ARG NH2 HH22 sing N N 86  
ARG OXT HXT  sing N N 87  
ASN N   CA   sing N N 88  
ASN N   H    sing N N 89  
ASN N   H2   sing N N 90  
ASN CA  C    sing N N 91  
ASN CA  CB   sing N N 92  
ASN CA  HA   sing N N 93  
ASN C   O    doub N N 94  
ASN C   OXT  sing N N 95  
ASN CB  CG   sing N N 96  
ASN CB  HB2  sing N N 97  
ASN CB  HB3  sing N N 98  
ASN CG  OD1  doub N N 99  
ASN CG  ND2  sing N N 100 
ASN ND2 HD21 sing N N 101 
ASN ND2 HD22 sing N N 102 
ASN OXT HXT  sing N N 103 
ASP N   CA   sing N N 104 
ASP N   H    sing N N 105 
ASP N   H2   sing N N 106 
ASP CA  C    sing N N 107 
ASP CA  CB   sing N N 108 
ASP CA  HA   sing N N 109 
ASP C   O    doub N N 110 
ASP C   OXT  sing N N 111 
ASP CB  CG   sing N N 112 
ASP CB  HB2  sing N N 113 
ASP CB  HB3  sing N N 114 
ASP CG  OD1  doub N N 115 
ASP CG  OD2  sing N N 116 
ASP OD2 HD2  sing N N 117 
ASP OXT HXT  sing N N 118 
GLN N   CA   sing N N 119 
GLN N   H    sing N N 120 
GLN N   H2   sing N N 121 
GLN CA  C    sing N N 122 
GLN CA  CB   sing N N 123 
GLN CA  HA   sing N N 124 
GLN C   O    doub N N 125 
GLN C   OXT  sing N N 126 
GLN CB  CG   sing N N 127 
GLN CB  HB2  sing N N 128 
GLN CB  HB3  sing N N 129 
GLN CG  CD   sing N N 130 
GLN CG  HG2  sing N N 131 
GLN CG  HG3  sing N N 132 
GLN CD  OE1  doub N N 133 
GLN CD  NE2  sing N N 134 
GLN NE2 HE21 sing N N 135 
GLN NE2 HE22 sing N N 136 
GLN OXT HXT  sing N N 137 
GLU N   CA   sing N N 138 
GLU N   H    sing N N 139 
GLU N   H2   sing N N 140 
GLU CA  C    sing N N 141 
GLU CA  CB   sing N N 142 
GLU CA  HA   sing N N 143 
GLU C   O    doub N N 144 
GLU C   OXT  sing N N 145 
GLU CB  CG   sing N N 146 
GLU CB  HB2  sing N N 147 
GLU CB  HB3  sing N N 148 
GLU CG  CD   sing N N 149 
GLU CG  HG2  sing N N 150 
GLU CG  HG3  sing N N 151 
GLU CD  OE1  doub N N 152 
GLU CD  OE2  sing N N 153 
GLU OE2 HE2  sing N N 154 
GLU OXT HXT  sing N N 155 
GLY N   CA   sing N N 156 
GLY N   H    sing N N 157 
GLY N   H2   sing N N 158 
GLY CA  C    sing N N 159 
GLY CA  HA2  sing N N 160 
GLY CA  HA3  sing N N 161 
GLY C   O    doub N N 162 
GLY C   OXT  sing N N 163 
GLY OXT HXT  sing N N 164 
HIS N   CA   sing N N 165 
HIS N   H    sing N N 166 
HIS N   H2   sing N N 167 
HIS CA  C    sing N N 168 
HIS CA  CB   sing N N 169 
HIS CA  HA   sing N N 170 
HIS C   O    doub N N 171 
HIS C   OXT  sing N N 172 
HIS CB  CG   sing N N 173 
HIS CB  HB2  sing N N 174 
HIS CB  HB3  sing N N 175 
HIS CG  ND1  sing Y N 176 
HIS CG  CD2  doub Y N 177 
HIS ND1 CE1  doub Y N 178 
HIS ND1 HD1  sing N N 179 
HIS CD2 NE2  sing Y N 180 
HIS CD2 HD2  sing N N 181 
HIS CE1 NE2  sing Y N 182 
HIS CE1 HE1  sing N N 183 
HIS NE2 HE2  sing N N 184 
HIS OXT HXT  sing N N 185 
HOH O   H1   sing N N 186 
HOH O   H2   sing N N 187 
ILE N   CA   sing N N 188 
ILE N   H    sing N N 189 
ILE N   H2   sing N N 190 
ILE CA  C    sing N N 191 
ILE CA  CB   sing N N 192 
ILE CA  HA   sing N N 193 
ILE C   O    doub N N 194 
ILE C   OXT  sing N N 195 
ILE CB  CG1  sing N N 196 
ILE CB  CG2  sing N N 197 
ILE CB  HB   sing N N 198 
ILE CG1 CD1  sing N N 199 
ILE CG1 HG12 sing N N 200 
ILE CG1 HG13 sing N N 201 
ILE CG2 HG21 sing N N 202 
ILE CG2 HG22 sing N N 203 
ILE CG2 HG23 sing N N 204 
ILE CD1 HD11 sing N N 205 
ILE CD1 HD12 sing N N 206 
ILE CD1 HD13 sing N N 207 
ILE OXT HXT  sing N N 208 
LEU N   CA   sing N N 209 
LEU N   H    sing N N 210 
LEU N   H2   sing N N 211 
LEU CA  C    sing N N 212 
LEU CA  CB   sing N N 213 
LEU CA  HA   sing N N 214 
LEU C   O    doub N N 215 
LEU C   OXT  sing N N 216 
LEU CB  CG   sing N N 217 
LEU CB  HB2  sing N N 218 
LEU CB  HB3  sing N N 219 
LEU CG  CD1  sing N N 220 
LEU CG  CD2  sing N N 221 
LEU CG  HG   sing N N 222 
LEU CD1 HD11 sing N N 223 
LEU CD1 HD12 sing N N 224 
LEU CD1 HD13 sing N N 225 
LEU CD2 HD21 sing N N 226 
LEU CD2 HD22 sing N N 227 
LEU CD2 HD23 sing N N 228 
LEU OXT HXT  sing N N 229 
LYS N   CA   sing N N 230 
LYS N   H    sing N N 231 
LYS N   H2   sing N N 232 
LYS CA  C    sing N N 233 
LYS CA  CB   sing N N 234 
LYS CA  HA   sing N N 235 
LYS C   O    doub N N 236 
LYS C   OXT  sing N N 237 
LYS CB  CG   sing N N 238 
LYS CB  HB2  sing N N 239 
LYS CB  HB3  sing N N 240 
LYS CG  CD   sing N N 241 
LYS CG  HG2  sing N N 242 
LYS CG  HG3  sing N N 243 
LYS CD  CE   sing N N 244 
LYS CD  HD2  sing N N 245 
LYS CD  HD3  sing N N 246 
LYS CE  NZ   sing N N 247 
LYS CE  HE2  sing N N 248 
LYS CE  HE3  sing N N 249 
LYS NZ  HZ1  sing N N 250 
LYS NZ  HZ2  sing N N 251 
LYS NZ  HZ3  sing N N 252 
LYS OXT HXT  sing N N 253 
MET N   CA   sing N N 254 
MET N   H    sing N N 255 
MET N   H2   sing N N 256 
MET CA  C    sing N N 257 
MET CA  CB   sing N N 258 
MET CA  HA   sing N N 259 
MET C   O    doub N N 260 
MET C   OXT  sing N N 261 
MET CB  CG   sing N N 262 
MET CB  HB2  sing N N 263 
MET CB  HB3  sing N N 264 
MET CG  SD   sing N N 265 
MET CG  HG2  sing N N 266 
MET CG  HG3  sing N N 267 
MET SD  CE   sing N N 268 
MET CE  HE1  sing N N 269 
MET CE  HE2  sing N N 270 
MET CE  HE3  sing N N 271 
MET OXT HXT  sing N N 272 
PHE N   CA   sing N N 273 
PHE N   H    sing N N 274 
PHE N   H2   sing N N 275 
PHE CA  C    sing N N 276 
PHE CA  CB   sing N N 277 
PHE CA  HA   sing N N 278 
PHE C   O    doub N N 279 
PHE C   OXT  sing N N 280 
PHE CB  CG   sing N N 281 
PHE CB  HB2  sing N N 282 
PHE CB  HB3  sing N N 283 
PHE CG  CD1  doub Y N 284 
PHE CG  CD2  sing Y N 285 
PHE CD1 CE1  sing Y N 286 
PHE CD1 HD1  sing N N 287 
PHE CD2 CE2  doub Y N 288 
PHE CD2 HD2  sing N N 289 
PHE CE1 CZ   doub Y N 290 
PHE CE1 HE1  sing N N 291 
PHE CE2 CZ   sing Y N 292 
PHE CE2 HE2  sing N N 293 
PHE CZ  HZ   sing N N 294 
PHE OXT HXT  sing N N 295 
PRO N   CA   sing N N 296 
PRO N   CD   sing N N 297 
PRO N   H    sing N N 298 
PRO CA  C    sing N N 299 
PRO CA  CB   sing N N 300 
PRO CA  HA   sing N N 301 
PRO C   O    doub N N 302 
PRO C   OXT  sing N N 303 
PRO CB  CG   sing N N 304 
PRO CB  HB2  sing N N 305 
PRO CB  HB3  sing N N 306 
PRO CG  CD   sing N N 307 
PRO CG  HG2  sing N N 308 
PRO CG  HG3  sing N N 309 
PRO CD  HD2  sing N N 310 
PRO CD  HD3  sing N N 311 
PRO OXT HXT  sing N N 312 
SER N   CA   sing N N 313 
SER N   H    sing N N 314 
SER N   H2   sing N N 315 
SER CA  C    sing N N 316 
SER CA  CB   sing N N 317 
SER CA  HA   sing N N 318 
SER C   O    doub N N 319 
SER C   OXT  sing N N 320 
SER CB  OG   sing N N 321 
SER CB  HB2  sing N N 322 
SER CB  HB3  sing N N 323 
SER OG  HG   sing N N 324 
SER OXT HXT  sing N N 325 
THR N   CA   sing N N 326 
THR N   H    sing N N 327 
THR N   H2   sing N N 328 
THR CA  C    sing N N 329 
THR CA  CB   sing N N 330 
THR CA  HA   sing N N 331 
THR C   O    doub N N 332 
THR C   OXT  sing N N 333 
THR CB  OG1  sing N N 334 
THR CB  CG2  sing N N 335 
THR CB  HB   sing N N 336 
THR OG1 HG1  sing N N 337 
THR CG2 HG21 sing N N 338 
THR CG2 HG22 sing N N 339 
THR CG2 HG23 sing N N 340 
THR OXT HXT  sing N N 341 
TRP N   CA   sing N N 342 
TRP N   H    sing N N 343 
TRP N   H2   sing N N 344 
TRP CA  C    sing N N 345 
TRP CA  CB   sing N N 346 
TRP CA  HA   sing N N 347 
TRP C   O    doub N N 348 
TRP C   OXT  sing N N 349 
TRP CB  CG   sing N N 350 
TRP CB  HB2  sing N N 351 
TRP CB  HB3  sing N N 352 
TRP CG  CD1  doub Y N 353 
TRP CG  CD2  sing Y N 354 
TRP CD1 NE1  sing Y N 355 
TRP CD1 HD1  sing N N 356 
TRP CD2 CE2  doub Y N 357 
TRP CD2 CE3  sing Y N 358 
TRP NE1 CE2  sing Y N 359 
TRP NE1 HE1  sing N N 360 
TRP CE2 CZ2  sing Y N 361 
TRP CE3 CZ3  doub Y N 362 
TRP CE3 HE3  sing N N 363 
TRP CZ2 CH2  doub Y N 364 
TRP CZ2 HZ2  sing N N 365 
TRP CZ3 CH2  sing Y N 366 
TRP CZ3 HZ3  sing N N 367 
TRP CH2 HH2  sing N N 368 
TRP OXT HXT  sing N N 369 
TYR N   CA   sing N N 370 
TYR N   H    sing N N 371 
TYR N   H2   sing N N 372 
TYR CA  C    sing N N 373 
TYR CA  CB   sing N N 374 
TYR CA  HA   sing N N 375 
TYR C   O    doub N N 376 
TYR C   OXT  sing N N 377 
TYR CB  CG   sing N N 378 
TYR CB  HB2  sing N N 379 
TYR CB  HB3  sing N N 380 
TYR CG  CD1  doub Y N 381 
TYR CG  CD2  sing Y N 382 
TYR CD1 CE1  sing Y N 383 
TYR CD1 HD1  sing N N 384 
TYR CD2 CE2  doub Y N 385 
TYR CD2 HD2  sing N N 386 
TYR CE1 CZ   doub Y N 387 
TYR CE1 HE1  sing N N 388 
TYR CE2 CZ   sing Y N 389 
TYR CE2 HE2  sing N N 390 
TYR CZ  OH   sing N N 391 
TYR OH  HH   sing N N 392 
TYR OXT HXT  sing N N 393 
VAL N   CA   sing N N 394 
VAL N   H    sing N N 395 
VAL N   H2   sing N N 396 
VAL CA  C    sing N N 397 
VAL CA  CB   sing N N 398 
VAL CA  HA   sing N N 399 
VAL C   O    doub N N 400 
VAL C   OXT  sing N N 401 
VAL CB  CG1  sing N N 402 
VAL CB  CG2  sing N N 403 
VAL CB  HB   sing N N 404 
VAL CG1 HG11 sing N N 405 
VAL CG1 HG12 sing N N 406 
VAL CG1 HG13 sing N N 407 
VAL CG2 HG21 sing N N 408 
VAL CG2 HG22 sing N N 409 
VAL CG2 HG23 sing N N 410 
VAL OXT HXT  sing N N 411 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' T32GM148376-01A1 1 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 1R35GM152079-01  2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6CJI 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 2 2' 
_space_group.name_Hall        'P 4cw 2c' 
_space_group.IT_number        95 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9MSQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013558 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013558 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009345 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 8.95735 ?       ? ? 7.27484  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ALA A 1 4   ? 33.52700 14.80300  4.68200   1.000 65.56000  ? 4   ALA A N    1 
ATOM   2    C CA   . ALA A 1 4   ? 32.37800 14.09300  4.06800   1.000 99.91000  ? 4   ALA A CA   1 
ATOM   3    C C    . ALA A 1 4   ? 31.08000 14.52600  4.73500   1.000 83.08000  ? 4   ALA A C    1 
ATOM   4    O O    . ALA A 1 4   ? 31.03400 14.51500  5.97200   1.000 83.54000  ? 4   ALA A O    1 
ATOM   5    C CB   . ALA A 1 4   ? 32.57400 12.61100  4.17700   1.000 108.64000 ? 4   ALA A CB   1 
ATOM   6    H HA   . ALA A 1 4   ? 32.33400 14.34600  3.10500   1.000 119.77000 ? 4   ALA A HA   1 
ATOM   7    H HB1  . ALA A 1 4   ? 32.10500 12.16500  3.45100   1.000 130.25000 ? 4   ALA A HB1  1 
ATOM   8    H HB2  . ALA A 1 4   ? 33.52100 12.40200  4.12400   1.000 130.25000 ? 4   ALA A HB2  1 
ATOM   9    H HB3  . ALA A 1 4   ? 32.22300 12.29500  5.02600   1.000 130.25000 ? 4   ALA A HB3  1 
ATOM   10   N N    . LYS A 1 5   ? 30.06000 14.85400  3.95000   1.000 80.63000  ? 5   LYS A N    1 
ATOM   11   C CA   . LYS A 1 5   ? 28.79800 15.41400  4.49400   1.000 76.95000  ? 5   LYS A CA   1 
ATOM   12   C C    . LYS A 1 5   ? 27.76600 14.31200  4.70000   1.000 79.94000  ? 5   LYS A C    1 
ATOM   13   O O    . LYS A 1 5   ? 27.30200 13.73700  3.70200   1.000 58.18000  ? 5   LYS A O    1 
ATOM   14   C CB   . LYS A 1 5   ? 28.23800 16.49400  3.56800   1.000 65.45000  ? 5   LYS A CB   1 
ATOM   15   H H    . LYS A 1 5   ? 30.08900 14.72000  3.06000   1.000 96.63000  ? 5   LYS A H    1 
ATOM   16   H HA   . LYS A 1 5   ? 28.99000 15.83200  5.37000   1.000 92.22000  ? 5   LYS A HA   1 
ATOM   17   N N    . VAL A 1 6   ? 27.44500 14.04900  5.95500   1.000 60.68000  ? 6   VAL A N    1 
ATOM   18   C CA   . VAL A 1 6   ? 26.42200 13.04100  6.30700   1.000 75.04000  ? 6   VAL A CA   1 
ATOM   19   C C    . VAL A 1 6   ? 25.05400 13.73000  6.28800   1.000 82.20000  ? 6   VAL A C    1 
ATOM   20   O O    . VAL A 1 6   ? 24.76400 14.50400  7.21100   1.000 71.81000  ? 6   VAL A O    1 
ATOM   21   C CB   . VAL A 1 6   ? 26.76400 12.39400  7.65900   1.000 67.96000  ? 6   VAL A CB   1 
ATOM   22   C CG1  . VAL A 1 6   ? 28.11600 11.70400  7.59200   1.000 107.75000 ? 6   VAL A CG1  1 
ATOM   23   C CG2  . VAL A 1 6   ? 26.74500 13.34900  8.84600   1.000 90.57000  ? 6   VAL A CG2  1 
ATOM   24   H H    . VAL A 1 6   ? 27.84600 14.47600  6.64000   1.000 72.69000  ? 6   VAL A H    1 
ATOM   25   H HA   . VAL A 1 6   ? 26.42500 12.34300  5.62500   1.000 89.92000  ? 6   VAL A HA   1 
ATOM   26   H HB   . VAL A 1 6   ? 26.08400 11.70100  7.82500   1.000 81.43000  ? 6   VAL A HB   1 
ATOM   27   H HG11 . VAL A 1 6   ? 28.14400 10.98200  8.24100   1.000 129.18000 ? 6   VAL A HG11 1 
ATOM   28   H HG12 . VAL A 1 6   ? 28.25100 11.34500  6.69900   1.000 129.18000 ? 6   VAL A HG12 1 
ATOM   29   H HG13 . VAL A 1 6   ? 28.81700 12.34700  7.79100   1.000 129.18000 ? 6   VAL A HG13 1 
ATOM   30   H HG21 . VAL A 1 6   ? 27.40300 13.05900  9.49900   1.000 108.57000 ? 6   VAL A HG21 1 
ATOM   31   H HG22 . VAL A 1 6   ? 26.96100 14.24800  8.55200   1.000 108.57000 ? 6   VAL A HG22 1 
ATOM   32   H HG23 . VAL A 1 6   ? 25.86400 13.34200  9.25600   1.000 108.57000 ? 6   VAL A HG23 1 
ATOM   33   N N    . GLU A 1 7   ? 24.26200 13.51700  5.24300   1.000 78.83000  ? 7   GLU A N    1 
ATOM   34   C CA   . GLU A 1 7   ? 22.90700 14.03400  5.23400   1.000 70.39000  ? 7   GLU A CA   1 
ATOM   35   C C    . GLU A 1 7   ? 22.05800 13.11900  6.11000   1.000 61.82000  ? 7   GLU A C    1 
ATOM   36   O O    . GLU A 1 7   ? 22.01000 11.90500  5.87900   1.000 76.94000  ? 7   GLU A O    1 
ATOM   37   C CB   . GLU A 1 7   ? 22.34800 14.13000  3.81800   1.000 88.49000  ? 7   GLU A CB   1 
ATOM   38   C CG   . GLU A 1 7   ? 23.25200 14.84200  2.83700   1.000 73.50000  ? 7   GLU A CG   1 
ATOM   39   C CD   . GLU A 1 7   ? 22.67000 14.81500  1.44200   1.000 89.36000  ? 7   GLU A CD   1 
ATOM   40   O OE1  . GLU A 1 7   ? 21.53300 14.30100  1.24300   1.000 85.08000  ? 7   GLU A OE1  1 
ATOM   41   O OE2  . GLU A 1 7   ? 23.37200 15.29400  0.53300   1.000 78.59000  ? 7   GLU A OE2  1 
ATOM   42   H H    . GLU A 1 7   ? 24.44800 12.97400  4.60200   1.000 94.47000  ? 7   GLU A H    1 
ATOM   43   H HA   . GLU A 1 7   ? 22.89100 14.93400  5.59600   1.000 84.34000  ? 7   GLU A HA   1 
ATOM   44   H HB2  . GLU A 1 7   ? 22.20000 13.23200  3.48200   1.000 106.07000 ? 7   GLU A HB2  1 
ATOM   45   H HB3  . GLU A 1 7   ? 21.50900 14.61600  3.84900   1.000 106.07000 ? 7   GLU A HB3  1 
ATOM   46   H HG2  . GLU A 1 7   ? 23.35700 15.76700  3.10800   1.000 88.08000  ? 7   GLU A HG2  1 
ATOM   47   H HG3  . GLU A 1 7   ? 24.11600 14.40200  2.81700   1.000 88.08000  ? 7   GLU A HG3  1 
ATOM   48   N N    . THR A 1 8   ? 21.42800 13.69100  7.13900   1.000 61.69000  ? 8   THR A N    1 
ATOM   49   C CA   . THR A 1 8   ? 20.43900 12.98300  7.93800   1.000 68.16000  ? 8   THR A CA   1 
ATOM   50   C C    . THR A 1 8   ? 19.04200 13.17600  7.35100   1.000 76.77000  ? 8   THR A C    1 
ATOM   51   O O    . THR A 1 8   ? 18.74200 14.19500  6.72100   1.000 71.07000  ? 8   THR A O    1 
ATOM   52   C CB   . THR A 1 8   ? 20.46900 13.45400  9.38800   1.000 60.53000  ? 8   THR A CB   1 
ATOM   53   O OG1  . THR A 1 8   ? 21.71700 13.05100  9.95900   1.000 59.33000  ? 8   THR A OG1  1 
ATOM   54   C CG2  . THR A 1 8   ? 19.32000 12.85500  10.18000  1.000 72.04000  ? 8   THR A CG2  1 
ATOM   55   H H    . THR A 1 8   ? 21.56100 14.50100  7.39400   1.000 73.91000  ? 8   THR A H    1 
ATOM   56   H HA   . THR A 1 8   ? 20.64300 12.03500  7.93100   1.000 81.66000  ? 8   THR A HA   1 
ATOM   57   H HB   . THR A 1 8   ? 20.37400 14.41800  9.43200   1.000 72.51000  ? 8   THR A HB   1 
ATOM   58   H HG1  . THR A 1 8   ? 21.75500 13.28800  10.76400  1.000 71.07000  ? 8   THR A HG1  1 
ATOM   59   H HG21 . THR A 1 8   ? 19.48300 12.95700  11.13100  1.000 86.32000  ? 8   THR A HG21 1 
ATOM   60   H HG22 . THR A 1 8   ? 18.49100 13.30400  9.95300   1.000 86.32000  ? 8   THR A HG22 1 
ATOM   61   H HG23 . THR A 1 8   ? 19.23300 11.91100  9.97600   1.000 86.32000  ? 8   THR A HG23 1 
ATOM   62   N N    . HIS A 1 9   ? 18.21000 12.15400  7.53100   1.000 67.14000  ? 9   HIS A N    1 
ATOM   63   C CA   . HIS A 1 9   ? 16.83100 12.13900  7.08200   1.000 77.17000  ? 9   HIS A CA   1 
ATOM   64   C C    . HIS A 1 9   ? 16.05300 11.29300  8.07100   1.000 79.57000  ? 9   HIS A C    1 
ATOM   65   O O    . HIS A 1 9   ? 16.61800 10.45900  8.78900   1.000 71.87000  ? 9   HIS A O    1 
ATOM   66   C CB   . HIS A 1 9   ? 16.71900 11.58200  5.67300   1.000 67.29000  ? 9   HIS A CB   1 
ATOM   67   C CG   . HIS A 1 9   ? 17.44800 12.38900  4.63900   1.000 84.52000  ? 9   HIS A CG   1 
ATOM   68   N ND1  . HIS A 1 9   ? 18.78200 12.19900  4.34500   1.000 79.14000  ? 9   HIS A ND1  1 
ATOM   69   C CD2  . HIS A 1 9   ? 17.03500 13.40700  3.84500   1.000 82.47000  ? 9   HIS A CD2  1 
ATOM   70   C CE1  . HIS A 1 9   ? 19.16200 13.07200  3.42900   1.000 71.14000  ? 9   HIS A CE1  1 
ATOM   71   N NE2  . HIS A 1 9   ? 18.11700 13.81100  3.10000   1.000 70.39000  ? 9   HIS A NE2  1 
ATOM   72   H H    . HIS A 1 9   ? 18.43500 11.42500  7.93000   1.000 80.45000  ? 9   HIS A H    1 
ATOM   73   H HA   . HIS A 1 9   ? 16.45800 13.03400  7.06900   1.000 92.48000  ? 9   HIS A HA   1 
ATOM   74   H HB2  . HIS A 1 9   ? 17.08800 10.68500  5.66200   1.000 80.62000  ? 9   HIS A HB2  1 
ATOM   75   H HB3  . HIS A 1 9   ? 15.78200 11.55800  5.42200   1.000 80.62000  ? 9   HIS A HB3  1 
ATOM   76   H HD2  . HIS A 1 9   ? 16.17700 13.76600  3.81100   1.000 98.84000  ? 9   HIS A HD2  1 
ATOM   77   H HE1  . HIS A 1 9   ? 20.01900 13.15300  3.07700   1.000 85.25000  ? 9   HIS A HE1  1 
ATOM   78   H HE2  . HIS A 1 9   ? 18.11500 14.44100  2.51500   1.000 84.35000  ? 9   HIS A HE2  1 
ATOM   79   N N    . GLU A 1 10  ? 14.74800 11.52000  8.10300   1.000 69.43000  ? 10  GLU A N    1 
ATOM   80   C CA   . GLU A 1 10  ? 13.87000 10.79500  9.03600   1.000 67.87000  ? 10  GLU A CA   1 
ATOM   81   C C    . GLU A 1 10  ? 13.05100 9.79400   8.24000   1.000 57.30000  ? 10  GLU A C    1 
ATOM   82   O O    . GLU A 1 10  ? 12.70800 10.09300  7.09400   1.000 51.69000  ? 10  GLU A O    1 
ATOM   83   C CB   . GLU A 1 10  ? 13.00200 11.79800  9.78800   1.000 74.44000  ? 10  GLU A CB   1 
ATOM   84   C CG   . GLU A 1 10  ? 13.79600 12.94700  10.39700  1.000 87.08000  ? 10  GLU A CG   1 
ATOM   85   C CD   . GLU A 1 10  ? 13.68300 14.23300  9.60100   1.000 105.29000 ? 10  GLU A CD   1 
ATOM   86   O OE1  . GLU A 1 10  ? 14.39900 14.37700  8.59000   1.000 99.93000  ? 10  GLU A OE1  1 
ATOM   87   O OE2  . GLU A 1 10  ? 12.86500 15.08800  9.99100   1.000 97.65000  ? 10  GLU A OE2  1 
ATOM   88   H H    . GLU A 1 10  ? 14.33700 12.11300  7.56100   1.000 83.19000  ? 10  GLU A H    1 
ATOM   89   H HA   . GLU A 1 10  ? 14.41900 10.31000  9.69000   1.000 81.32000  ? 10  GLU A HA   1 
ATOM   90   H HB2  . GLU A 1 10  ? 12.34000 12.16500  9.16800   1.000 89.20000  ? 10  GLU A HB2  1 
ATOM   91   H HB3  . GLU A 1 10  ? 12.51900 11.32500  10.49700  1.000 89.20000  ? 10  GLU A HB3  1 
ATOM   92   H HG2  . GLU A 1 10  ? 13.47500 13.11300  11.30700  1.000 104.37000 ? 10  GLU A HG2  1 
ATOM   93   H HG3  . GLU A 1 10  ? 14.74200 12.69300  10.45400  1.000 104.37000 ? 10  GLU A HG3  1 
ATOM   94   N N    . PHE A 1 11  ? 12.81600 8.63900   8.82700   1.000 49.26000  ? 11  PHE A N    1 
ATOM   95   C CA   . PHE A 1 11  ? 11.97800 7.59900   8.20900   1.000 57.09000  ? 11  PHE A CA   1 
ATOM   96   C C    . PHE A 1 11  ? 10.54000 7.98100   8.39000   1.000 66.37000  ? 11  PHE A C    1 
ATOM   97   O O    . PHE A 1 11  ? 10.22400 8.68300   9.36000   1.000 59.49000  ? 11  PHE A O    1 
ATOM   98   C CB   . PHE A 1 11  ? 12.20000 6.24800   8.88500   1.000 60.58000  ? 11  PHE A CB   1 
ATOM   99   C CG   . PHE A 1 11  ? 13.44800 5.47300   8.50200   1.000 63.59000  ? 11  PHE A CG   1 
ATOM   100  C CD1  . PHE A 1 11  ? 13.53500 4.81900   7.28400   1.000 71.94000  ? 11  PHE A CD1  1 
ATOM   101  C CD2  . PHE A 1 11  ? 14.51100 5.36900   9.38400   1.000 69.32000  ? 11  PHE A CD2  1 
ATOM   102  C CE1  . PHE A 1 11  ? 14.66700 4.10200   6.95300   1.000 58.55000  ? 11  PHE A CE1  1 
ATOM   103  C CE2  . PHE A 1 11  ? 15.63900 4.65200   9.04600   1.000 64.39000  ? 11  PHE A CE2  1 
ATOM   104  C CZ   . PHE A 1 11  ? 15.71100 4.01700   7.83600   1.000 64.87000  ? 11  PHE A CZ   1 
ATOM   105  H H    . PHE A 1 11  ? 13.18000 8.42900   9.62200   1.000 58.98000  ? 11  PHE A H    1 
ATOM   106  H HA   . PHE A 1 11  ? 12.18900 7.52700   7.24200   1.000 68.38000  ? 11  PHE A HA   1 
ATOM   107  H HB2  . PHE A 1 11  ? 12.21700 6.39600   9.85600   1.000 72.57000  ? 11  PHE A HB2  1 
ATOM   108  H HB3  . PHE A 1 11  ? 11.41800 5.68300   8.69500   1.000 72.57000  ? 11  PHE A HB3  1 
ATOM   109  H HD1  . PHE A 1 11  ? 12.81500 4.87100   6.67500   1.000 86.20000  ? 11  PHE A HD1  1 
ATOM   110  H HD2  . PHE A 1 11  ? 14.46400 5.79900   10.21900  1.000 83.06000  ? 11  PHE A HD2  1 
ATOM   111  H HE1  . PHE A 1 11  ? 14.71900 3.66700   6.11700   1.000 70.14000  ? 11  PHE A HE1  1 
ATOM   112  H HE2  . PHE A 1 11  ? 16.36000 4.59700   9.65200   1.000 77.15000  ? 11  PHE A HE2  1 
ATOM   113  H HZ   . PHE A 1 11  ? 16.48600 3.53200   7.60600   1.000 77.72000  ? 11  PHE A HZ   1 
ATOM   114  N N    . THR A 1 12  ? 9.68000  7.54100   7.48800   1.000 64.70000  ? 12  THR A N    1 
ATOM   115  C CA   . THR A 1 12  ? 8.23600  7.73800   7.59000   1.000 54.09000  ? 12  THR A CA   1 
ATOM   116  C C    . THR A 1 12  ? 7.77200  6.97500   8.79200   1.000 63.19000  ? 12  THR A C    1 
ATOM   117  O O    . THR A 1 12  ? 8.45800  6.02900   9.16700   1.000 70.07000  ? 12  THR A O    1 
ATOM   118  C CB   . THR A 1 12  ? 7.64000  7.23200   6.28600   1.000 78.12000  ? 12  THR A CB   1 
ATOM   119  O OG1  . THR A 1 12  ? 7.81400  8.29500   5.35900   1.000 86.46000  ? 12  THR A OG1  1 
ATOM   120  C CG2  . THR A 1 12  ? 6.17200  6.89900   6.39100   1.000 90.74000  ? 12  THR A CG2  1 
ATOM   121  H H    . THR A 1 12  ? 9.92000  7.08000   6.75100   1.000 77.52000  ? 12  THR A H    1 
ATOM   122  H HA   . THR A 1 12  ? 8.03800  8.69100   7.69800   1.000 64.79000  ? 12  THR A HA   1 
ATOM   123  H HB   . THR A 1 12  ? 8.12700  6.43200   5.97500   1.000 93.62000  ? 12  THR A HB   1 
ATOM   124  H HG1  . THR A 1 12  ? 7.24300  8.21600   4.71800   1.000 103.63000 ? 12  THR A HG1  1 
ATOM   125  H HG21 . THR A 1 12  ? 5.78400  6.89200   5.50200   1.000 108.76000 ? 12  THR A HG21 1 
ATOM   126  H HG22 . THR A 1 12  ? 6.07100  6.02300   6.80100   1.000 108.76000 ? 12  THR A HG22 1 
ATOM   127  H HG23 . THR A 1 12  ? 5.72600  7.56900   6.93300   1.000 108.76000 ? 12  THR A HG23 1 
ATOM   128  N N    . ALA A 1 13  ? 6.66000  7.35400   9.40700   1.000 70.12000  ? 13  ALA A N    1 
ATOM   129  C CA   . ALA A 1 13  ? 6.24300  6.71400   10.64200  1.000 65.59000  ? 13  ALA A CA   1 
ATOM   130  C C    . ALA A 1 13  ? 5.91200  5.25100   10.40600  1.000 67.46000  ? 13  ALA A C    1 
ATOM   131  O O    . ALA A 1 13  ? 6.18200  4.40600   11.27700  1.000 55.30000  ? 13  ALA A O    1 
ATOM   132  C CB   . ALA A 1 13  ? 5.04300  7.43100   11.26300  1.000 70.91000  ? 13  ALA A CB   1 
ATOM   133  H H    . ALA A 1 13  ? 6.10300  7.92500   9.08600   1.000 84.02000  ? 13  ALA A H    1 
ATOM   134  H HA   . ALA A 1 13  ? 6.97500  6.77600   11.27600  1.000 78.58000  ? 13  ALA A HA   1 
ATOM   135  H HB1  . ALA A 1 13  ? 4.79300  6.97600   12.08300  1.000 84.97000  ? 13  ALA A HB1  1 
ATOM   136  H HB2  . ALA A 1 13  ? 5.28800  8.34900   11.45600  1.000 84.97000  ? 13  ALA A HB2  1 
ATOM   137  H HB3  . ALA A 1 13  ? 4.30400  7.41100   10.63600  1.000 84.97000  ? 13  ALA A HB3  1 
ATOM   138  N N    . GLU A 1 14  ? 5.28700  4.93500   9.25800   1.000 74.54000  ? 14  GLU A N    1 
ATOM   139  C CA   . GLU A 1 14  ? 4.98100  3.53400   8.95500   1.000 84.59000  ? 14  GLU A CA   1 
ATOM   140  C C    . GLU A 1 14  ? 6.25900  2.71100   8.75800   1.000 75.39000  ? 14  GLU A C    1 
ATOM   141  O O    . GLU A 1 14  ? 6.32700  1.54400   9.16700   1.000 64.99000  ? 14  GLU A O    1 
ATOM   142  C CB   . GLU A 1 14  ? 4.04900  3.38900   7.73400   1.000 64.58000  ? 14  GLU A CB   1 
ATOM   143  C CG   . GLU A 1 14  ? 2.96600  4.43300   7.54600   1.000 93.63000  ? 14  GLU A CG   1 
ATOM   144  C CD   . GLU A 1 14  ? 3.40000  5.57500   6.65300   1.000 121.33000 ? 14  GLU A CD   1 
ATOM   145  O OE1  . GLU A 1 14  ? 3.89100  5.30600   5.53400   1.000 127.67000 ? 14  GLU A OE1  1 
ATOM   146  O OE2  . GLU A 1 14  ? 3.29700  6.74400   7.08700   1.000 110.75000 ? 14  GLU A OE2  1 
ATOM   147  H H    . GLU A 1 14  ? 5.03800  5.49800   8.65700   1.000 89.32000  ? 14  GLU A H    1 
ATOM   148  H HA   . GLU A 1 14  ? 4.49200  3.17400   9.71200   1.000 101.39000 ? 14  GLU A HA   1 
ATOM   149  H HB2  . GLU A 1 14  ? 4.60000  3.41000   6.93600   1.000 77.37000  ? 14  GLU A HB2  1 
ATOM   150  H HB3  . GLU A 1 14  ? 3.60000  2.53200   7.80400   1.000 77.37000  ? 14  GLU A HB3  1 
ATOM   151  H HG2  . GLU A 1 14  ? 2.19100  4.01500   7.14100   1.000 112.23000 ? 14  GLU A HG2  1 
ATOM   152  H HG3  . GLU A 1 14  ? 2.73000  4.80300   8.41100   1.000 112.23000 ? 14  GLU A HG3  1 
ATOM   153  N N    . ILE A 1 15  ? 7.27600  3.30500   8.14800   1.000 65.41000  ? 15  ILE A N    1 
ATOM   154  C CA   . ILE A 1 15  ? 8.55000  2.58100   7.90600   1.000 70.36000  ? 15  ILE A CA   1 
ATOM   155  C C    . ILE A 1 15  ? 9.27000  2.42900   9.25000   1.000 55.93000  ? 15  ILE A C    1 
ATOM   156  O O    . ILE A 1 15  ? 9.79300  1.38000   9.45400   1.000 60.15000  ? 15  ILE A O    1 
ATOM   157  C CB   . ILE A 1 15  ? 9.42100  3.26500   6.83900   1.000 74.68000  ? 15  ILE A CB   1 
ATOM   158  C CG1  . ILE A 1 15  ? 8.72400  3.29800   5.47800   1.000 69.30000  ? 15  ILE A CG1  1 
ATOM   159  C CG2  . ILE A 1 15  ? 10.79900 2.61100   6.75200   1.000 55.07000  ? 15  ILE A CG2  1 
ATOM   160  C CD1  . ILE A 1 15  ? 8.53200  1.94000   4.82600   1.000 70.93000  ? 15  ILE A CD1  1 
ATOM   161  H H    . ILE A 1 15  ? 7.24900  4.16300   7.86900   1.000 78.37000  ? 15  ILE A H    1 
ATOM   162  H HA   . ILE A 1 15  ? 8.33200  1.68700   7.58300   1.000 84.31000  ? 15  ILE A HA   1 
ATOM   163  H HB   . ILE A 1 15  ? 9.55200  4.19300   7.12200   1.000 89.49000  ? 15  ILE A HB   1 
ATOM   164  H HG12 . ILE A 1 15  ? 7.84700  3.71800   5.58700   1.000 83.03000  ? 15  ILE A HG12 1 
ATOM   165  H HG13 . ILE A 1 15  ? 9.25000  3.86100   4.87400   1.000 83.03000  ? 15  ILE A HG13 1 
ATOM   166  H HG21 . ILE A 1 15  ? 11.21700 2.84700   5.90800   1.000 65.96000  ? 15  ILE A HG21 1 
ATOM   167  H HG22 . ILE A 1 15  ? 11.35600 2.92200   7.48600   1.000 65.96000  ? 15  ILE A HG22 1 
ATOM   168  H HG23 . ILE A 1 15  ? 10.70500 1.64400   6.80500   1.000 65.96000  ? 15  ILE A HG23 1 
ATOM   169  H HD11 . ILE A 1 15  ? 7.94000  2.03400   4.05600   1.000 84.99000  ? 15  ILE A HD11 1 
ATOM   170  H HD12 . ILE A 1 15  ? 9.39400  1.59100   4.52900   1.000 84.99000  ? 15  ILE A HD12 1 
ATOM   171  H HD13 . ILE A 1 15  ? 8.13300  1.31600   5.46200   1.000 84.99000  ? 15  ILE A HD13 1 
ATOM   172  N N    . SER A 1 16  ? 9.23100  3.41000   10.13400  1.000 51.70000  ? 16  SER A N    1 
ATOM   173  C CA   . SER A 1 16  ? 9.97500  3.31900   11.40400  1.000 57.30000  ? 16  SER A CA   1 
ATOM   174  C C    . SER A 1 16  ? 9.32000  2.24900   12.26900  1.000 53.40000  ? 16  SER A C    1 
ATOM   175  O O    . SER A 1 16  ? 10.04300 1.59000   13.00100  1.000 56.75000  ? 16  SER A O    1 
ATOM   176  C CB   . SER A 1 16  ? 10.02700 4.63600   12.08900  1.000 56.53000  ? 16  SER A CB   1 
ATOM   177  O OG   . SER A 1 16  ? 10.68500 4.54400   13.34200  1.000 56.46000  ? 16  SER A OG   1 
ATOM   178  H H    . SER A 1 16  ? 8.74400  4.16000   10.00800  1.000 61.92000  ? 16  SER A H    1 
ATOM   179  H HA   . SER A 1 16  ? 10.90200 3.03300   11.20200  1.000 68.63000  ? 16  SER A HA   1 
ATOM   180  H HB2  . SER A 1 16  ? 10.50100 5.27300   11.52000  1.000 67.71000  ? 16  SER A HB2  1 
ATOM   181  H HB3  . SER A 1 16  ? 9.11800  4.96400   12.22100  1.000 67.71000  ? 16  SER A HB3  1 
ATOM   182  H HG   . SER A 1 16  ? 11.40900 4.12100   13.23100  1.000 67.63000  ? 16  SER A HG   1 
ATOM   183  N N    . GLN A 1 17  ? 8.01300  2.07400   12.14200  1.000 63.27000  ? 17  GLN A N    1 
ATOM   184  C CA   . GLN A 1 17  ? 7.25000  1.11200   12.96800  1.000 64.40000  ? 17  GLN A CA   1 
ATOM   185  C C    . GLN A 1 17  ? 7.41500  -0.30100  12.43100  1.000 70.59000  ? 17  GLN A C    1 
ATOM   186  O O    . GLN A 1 17  ? 7.29400  -1.22500  13.21100  1.000 56.56000  ? 17  GLN A O    1 
ATOM   187  C CB   . GLN A 1 17  ? 5.76900  1.49500   13.01200  1.000 30.00000  ? 17  GLN A CB   1 
ATOM   188  H H    . GLN A 1 17  ? 7.51100  2.49300   11.58400  1.000 63.27000  ? 17  GLN A H    1 
ATOM   189  H HA   . GLN A 1 17  ? 7.60200  1.14200   13.87200  1.000 64.40000  ? 17  GLN A HA   1 
ATOM   190  N N    . LEU A 1 18  ? 7.58600  -0.43000  11.12600  1.000 70.56000  ? 18  LEU A N    1 
ATOM   191  C CA   . LEU A 1 18  ? 7.88100  -1.73200  10.50400  1.000 74.02000  ? 18  LEU A CA   1 
ATOM   192  C C    . LEU A 1 18  ? 9.27700  -2.14300  10.97300  1.000 61.39000  ? 18  LEU A C    1 
ATOM   193  O O    . LEU A 1 18  ? 9.41800  -3.26700  11.39400  1.000 53.78000  ? 18  LEU A O    1 
ATOM   194  C CB   . LEU A 1 18  ? 7.77500  -1.65200  8.98600   1.000 66.55000  ? 18  LEU A CB   1 
ATOM   195  C CG   . LEU A 1 18  ? 8.16300  -2.91400  8.21200   1.000 72.52000  ? 18  LEU A CG   1 
ATOM   196  C CD1  . LEU A 1 18  ? 7.26800  -4.06700  8.58100   1.000 59.93000  ? 18  LEU A CD1  1 
ATOM   197  C CD2  . LEU A 1 18  ? 8.11200  -2.66600  6.72600   1.000 69.62000  ? 18  LEU A CD2  1 
ATOM   198  H H    . LEU A 1 18  ? 7.53100  0.27800   10.56900  1.000 84.55000  ? 18  LEU A H    1 
ATOM   199  H HA   . LEU A 1 18  ? 7.22700  -2.39400  10.84100  1.000 88.70000  ? 18  LEU A HA   1 
ATOM   200  H HB2  . LEU A 1 18  ? 6.84600  -1.42100  8.75600   1.000 79.74000  ? 18  LEU A HB2  1 
ATOM   201  H HB3  . LEU A 1 18  ? 8.34600  -0.91100  8.67800   1.000 79.74000  ? 18  LEU A HB3  1 
ATOM   202  H HG   . LEU A 1 18  ? 9.09500  -3.15500  8.44900   1.000 86.90000  ? 18  LEU A HG   1 
ATOM   203  H HD11 . LEU A 1 18  ? 7.33700  -4.75800  7.90200   1.000 71.79000  ? 18  LEU A HD11 1 
ATOM   204  H HD12 . LEU A 1 18  ? 7.54100  -4.43000  9.44100   1.000 71.79000  ? 18  LEU A HD12 1 
ATOM   205  H HD13 . LEU A 1 18  ? 6.34800  -3.75800  8.63700   1.000 71.79000  ? 18  LEU A HD13 1 
ATOM   206  H HD21 . LEU A 1 18  ? 8.63400  -3.34300  6.26300   1.000 83.42000  ? 18  LEU A HD21 1 
ATOM   207  H HD22 . LEU A 1 18  ? 8.47700  -1.78600  6.53200   1.000 83.42000  ? 18  LEU A HD22 1 
ATOM   208  H HD23 . LEU A 1 18  ? 7.18800  -2.70500  6.42200   1.000 83.42000  ? 18  LEU A HD23 1 
ATOM   209  N N    . MET A 1 19  ? 10.25300 -1.25000  10.90800  1.000 54.75000  ? 19  MET A N    1 
ATOM   210  C CA   . MET A 1 19  ? 11.63400 -1.60700  11.27000  1.000 62.53000  ? 19  MET A CA   1 
ATOM   211  C C    . MET A 1 19  ? 11.62700 -2.08600  12.70900  1.000 55.21000  ? 19  MET A C    1 
ATOM   212  O O    . MET A 1 19  ? 12.25200 -3.07600  12.90800  1.000 52.19000  ? 19  MET A O    1 
ATOM   213  C CB   . MET A 1 19  ? 12.56800 -0.41200  11.09400  1.000 58.58000  ? 19  MET A CB   1 
ATOM   214  C CG   . MET A 1 19  ? 12.90200 -0.09900  9.65500   1.000 61.00000  ? 19  MET A CG   1 
ATOM   215  S SD   . MET A 1 19  ? 14.30600 1.01600   9.47300   1.000 66.77000  ? 19  MET A SD   1 
ATOM   216  C CE   . MET A 1 19  ? 13.94800 2.31300   10.66400  1.000 79.72000  ? 19  MET A CE   1 
ATOM   217  H H    . MET A 1 19  ? 10.12500 -0.40400  10.62100  1.000 65.57000  ? 19  MET A H    1 
ATOM   218  H HA   . MET A 1 19  ? 11.93000 -2.34900  10.68600  1.000 74.92000  ? 19  MET A HA   1 
ATOM   219  H HB2  . MET A 1 19  ? 12.14200 0.37200   11.49900  1.000 70.17000  ? 19  MET A HB2  1 
ATOM   220  H HB3  . MET A 1 19  ? 13.40000 -0.58900  11.58400  1.000 70.17000  ? 19  MET A HB3  1 
ATOM   221  H HG2  . MET A 1 19  ? 13.10300 -0.93300  9.18400   1.000 73.08000  ? 19  MET A HG2  1 
ATOM   222  H HG3  . MET A 1 19  ? 12.12600 0.30500   9.22500   1.000 73.08000  ? 19  MET A HG3  1 
ATOM   223  H HE1  . MET A 1 19  ? 14.75400 2.83600   10.82700  1.000 95.54000  ? 19  MET A HE1  1 
ATOM   224  H HE2  . MET A 1 19  ? 13.24100 2.88900   10.31700  1.000 95.54000  ? 19  MET A HE2  1 
ATOM   225  H HE3  . MET A 1 19  ? 13.66100 1.92000   11.50700  1.000 95.54000  ? 19  MET A HE3  1 
ATOM   226  N N    . SER A 1 20  ? 10.89900 -1.42900  13.60400  1.000 76.77000  ? 20  SER A N    1 
ATOM   227  C CA   . SER A 1 20  ? 10.85900 -1.75000  15.05100  1.000 69.18000  ? 20  SER A CA   1 
ATOM   228  C C    . SER A 1 20  ? 10.19200 -3.10000  15.28100  1.000 65.19000  ? 20  SER A C    1 
ATOM   229  O O    . SER A 1 20  ? 10.66800 -3.86700  16.10700  1.000 67.17000  ? 20  SER A O    1 
ATOM   230  C CB   . SER A 1 20  ? 10.13400 -0.69300  15.79600  1.000 57.94000  ? 20  SER A CB   1 
ATOM   231  O OG   . SER A 1 20  ? 10.94200 0.46100   15.95600  1.000 82.31000  ? 20  SER A OG   1 
ATOM   232  H H    . SER A 1 20  ? 10.38000 -0.73300  13.35900  1.000 91.99000  ? 20  SER A H    1 
ATOM   233  H HA   . SER A 1 20  ? 11.78400 -1.79200  15.38800  1.000 82.89000  ? 20  SER A HA   1 
ATOM   234  H HB2  . SER A 1 20  ? 9.32100  -0.45600  15.30900  1.000 69.41000  ? 20  SER A HB2  1 
ATOM   235  H HB3  . SER A 1 20  ? 9.87700  -1.03500  16.67200  1.000 69.41000  ? 20  SER A HB3  1 
ATOM   236  H HG   . SER A 1 20  ? 11.14500 0.75100   15.18800  1.000 98.65000  ? 20  SER A HG   1 
ATOM   237  N N    . LEU A 1 21  ? 9.09600  -3.34400  14.59600  1.000 59.66000  ? 21  LEU A N    1 
ATOM   238  C CA   . LEU A 1 21  ? 8.39300  -4.62700  14.71900  1.000 61.82000  ? 21  LEU A CA   1 
ATOM   239  C C    . LEU A 1 21  ? 9.38500  -5.74600  14.44300  1.000 67.03000  ? 21  LEU A C    1 
ATOM   240  O O    . LEU A 1 21  ? 9.55900  -6.52000  15.35000  1.000 72.73000  ? 21  LEU A O    1 
ATOM   241  C CB   . LEU A 1 21  ? 7.23900  -4.61900  13.72700  1.000 68.41000  ? 21  LEU A CB   1 
ATOM   242  C CG   . LEU A 1 21  ? 6.42000  -5.90500  13.62200  1.000 76.09000  ? 21  LEU A CG   1 
ATOM   243  C CD1  . LEU A 1 21  ? 5.01400  -5.53300  13.22200  1.000 75.62000  ? 21  LEU A CD1  1 
ATOM   244  C CD2  . LEU A 1 21  ? 7.01400  -6.88100  12.63300  1.000 68.69000  ? 21  LEU A CD2  1 
ATOM   245  H H    . LEU A 1 21  ? 8.75300  -2.74200  14.01800  1.000 71.47000  ? 21  LEU A H    1 
ATOM   246  H HA   . LEU A 1 21  ? 8.04200  -4.71500  15.64000  1.000 74.06000  ? 21  LEU A HA   1 
ATOM   247  H HB2  . LEU A 1 21  ? 6.63100  -3.88500  13.97200  1.000 81.96000  ? 21  LEU A HB2  1 
ATOM   248  H HB3  . LEU A 1 21  ? 7.60000  -4.41100  12.83700  1.000 81.96000  ? 21  LEU A HB3  1 
ATOM   249  H HG   . LEU A 1 21  ? 6.39400  -6.33400  14.51500  1.000 91.18000  ? 21  LEU A HG   1 
ATOM   250  H HD11 . LEU A 1 21  ? 4.51400  -6.33800  13.00500  1.000 90.62000  ? 21  LEU A HD11 1 
ATOM   251  H HD12 . LEU A 1 21  ? 4.57900  -5.07000  13.95600  1.000 90.62000  ? 21  LEU A HD12 1 
ATOM   252  H HD13 . LEU A 1 21  ? 5.04300  -4.95100  12.44400  1.000 90.62000  ? 21  LEU A HD13 1 
ATOM   253  H HD21 . LEU A 1 21  ? 7.55800  -7.53400  13.10500  1.000 82.31000  ? 21  LEU A HD21 1 
ATOM   254  H HD22 . LEU A 1 21  ? 6.30000  -7.33700  12.15800  1.000 82.31000  ? 21  LEU A HD22 1 
ATOM   255  H HD23 . LEU A 1 21  ? 7.56700  -6.39900  11.99800  1.000 82.31000  ? 21  LEU A HD23 1 
ATOM   256  N N    . ILE A 1 22  ? 10.04500 -5.76900  13.28400  1.000 66.63000  ? 22  ILE A N    1 
ATOM   257  C CA   . ILE A 1 22  ? 10.92300 -6.89300  12.86300  1.000 63.59000  ? 22  ILE A CA   1 
ATOM   258  C C    . ILE A 1 22  ? 12.13800 -7.00100  13.78000  1.000 62.94000  ? 22  ILE A C    1 
ATOM   259  O O    . ILE A 1 22  ? 12.48800 -8.12900  14.14500  1.000 78.61000  ? 22  ILE A O    1 
ATOM   260  C CB   . ILE A 1 22  ? 11.35300 -6.69700  11.39900  1.000 49.13000  ? 22  ILE A CB   1 
ATOM   261  C CG1  . ILE A 1 22  ? 10.17700 -6.82000  10.44200  1.000 48.94000  ? 22  ILE A CG1  1 
ATOM   262  C CG2  . ILE A 1 22  ? 12.48400 -7.64800  11.01300  1.000 44.85000  ? 22  ILE A CG2  1 
ATOM   263  C CD1  . ILE A 1 22  ? 10.24700 -5.87200  9.26200   1.000 59.42000  ? 22  ILE A CD1  1 
ATOM   264  H H    . ILE A 1 22  ? 10.00000 -5.08300  12.70000  1.000 79.83000  ? 22  ILE A H    1 
ATOM   265  H HA   . ILE A 1 22  ? 10.41400 -7.72100  12.92300  1.000 76.18000  ? 22  ILE A HA   1 
ATOM   266  H HB   . ILE A 1 22  ? 11.69600 -5.78500  11.31900  1.000 58.83000  ? 22  ILE A HB   1 
ATOM   267  H HG12 . ILE A 1 22  ? 10.14400 -7.73800  10.10500  1.000 58.60000  ? 22  ILE A HG12 1 
ATOM   268  H HG13 . ILE A 1 22  ? 9.34800  -6.65000  10.93300  1.000 58.60000  ? 22  ILE A HG13 1 
ATOM   269  H HG21 . ILE A 1 22  ? 12.50200 -7.75700  10.04700  1.000 53.70000  ? 22  ILE A HG21 1 
ATOM   270  H HG22 . ILE A 1 22  ? 13.33400 -7.28300  11.30900  1.000 53.70000  ? 22  ILE A HG22 1 
ATOM   271  H HG23 . ILE A 1 22  ? 12.34200 -8.51300  11.43000  1.000 53.70000  ? 22  ILE A HG23 1 
ATOM   272  H HD11 . ILE A 1 22  ? 9.40100  -5.88800  8.77500   1.000 71.18000  ? 22  ILE A HD11 1 
ATOM   273  H HD12 . ILE A 1 22  ? 10.42000 -4.96600  9.58100   1.000 71.18000  ? 22  ILE A HD12 1 
ATOM   274  H HD13 . ILE A 1 22  ? 10.96800 -6.14900  8.66700   1.000 71.18000  ? 22  ILE A HD13 1 
ATOM   275  N N    . ILE A 1 23  ? 12.76500 -5.89600  14.14100  1.000 64.65000  ? 23  ILE A N    1 
ATOM   276  C CA   . ILE A 1 23  ? 14.01400 -5.99000  14.88000  1.000 76.54000  ? 23  ILE A CA   1 
ATOM   277  C C    . ILE A 1 23  ? 13.75900 -6.54900  16.26900  1.000 80.08000  ? 23  ILE A C    1 
ATOM   278  O O    . ILE A 1 23  ? 14.66500 -7.13300  16.89400  1.000 68.88000  ? 23  ILE A O    1 
ATOM   279  C CB   . ILE A 1 23  ? 14.68900 -4.61000  14.93000  1.000 64.80000  ? 23  ILE A CB   1 
ATOM   280  C CG1  . ILE A 1 23  ? 15.91400 -4.66100  15.82900  1.000 61.72000  ? 23  ILE A CG1  1 
ATOM   281  C CG2  . ILE A 1 23  ? 13.73300 -3.59800  15.44600  1.000 71.60000  ? 23  ILE A CG2  1 
ATOM   282  C CD1  . ILE A 1 23  ? 16.98900 -3.68900  15.43500  1.000 76.70000  ? 23  ILE A CD1  1 
ATOM   283  H H    . ILE A 1 23  ? 12.50500 -5.09700  13.95700  1.000 77.46000  ? 23  ILE A H    1 
ATOM   284  H HA   . ILE A 1 23  ? 14.61500 -6.59900  14.42300  1.000 91.72000  ? 23  ILE A HA   1 
ATOM   285  H HB   . ILE A 1 23  ? 14.96400 -4.36600  14.03200  1.000 77.63000  ? 23  ILE A HB   1 
ATOM   286  H HG12 . ILE A 1 23  ? 15.64400 -4.45300  16.73700  1.000 73.94000  ? 23  ILE A HG12 1 
ATOM   287  H HG13 . ILE A 1 23  ? 16.29300 -5.55300  15.79200  1.000 73.94000  ? 23  ILE A HG13 1 
ATOM   288  H HG21 . ILE A 1 23  ? 14.11900 -2.71500  15.33700  1.000 85.80000  ? 23  ILE A HG21 1 
ATOM   289  H HG22 . ILE A 1 23  ? 12.90500 -3.66200  14.94600  1.000 85.80000  ? 23  ILE A HG22 1 
ATOM   290  H HG23 . ILE A 1 23  ? 13.56600 -3.77200  16.38600  1.000 85.80000  ? 23  ILE A HG23 1 
ATOM   291  H HD11 . ILE A 1 23  ? 17.70200 -3.72400  16.09200  1.000 91.92000  ? 23  ILE A HD11 1 
ATOM   292  H HD12 . ILE A 1 23  ? 17.33100 -3.93400  14.56100  1.000 91.92000  ? 23  ILE A HD12 1 
ATOM   293  H HD13 . ILE A 1 23  ? 16.61200 -2.79600  15.40400  1.000 91.92000  ? 23  ILE A HD13 1 
ATOM   294  N N    . ASN A 1 24  ? 12.52600 -6.37900  16.77300  1.000 69.03000  ? 24  ASN A N    1 
ATOM   295  C CA   . ASN A 1 24  ? 12.15300 -6.80600  18.11700  1.000 78.28000  ? 24  ASN A CA   1 
ATOM   296  C C    . ASN A 1 24  ? 11.55400 -8.20700  18.10800  1.000 85.53000  ? 24  ASN A C    1 
ATOM   297  O O    . ASN A 1 24  ? 11.73800 -8.96300  19.07600  1.000 77.75000  ? 24  ASN A O    1 
ATOM   298  C CB   . ASN A 1 24  ? 11.18100 -5.79500  18.74500  1.000 70.99000  ? 24  ASN A CB   1 
ATOM   299  C CG   . ASN A 1 24  ? 11.84500 -4.44600  19.06500  1.000 72.52000  ? 24  ASN A CG   1 
ATOM   300  O OD1  . ASN A 1 24  ? 11.32900 -3.38900  18.71400  1.000 63.29000  ? 24  ASN A OD1  1 
ATOM   301  N ND2  . ASN A 1 24  ? 12.98200 -4.48600  19.74800  1.000 83.77000  ? 24  ASN A ND2  1 
ATOM   302  H H    . ASN A 1 24  ? 11.87900 -6.01100  16.34200  1.000 82.72000  ? 24  ASN A H    1 
ATOM   303  H HA   . ASN A 1 24  ? 12.93500 -6.82200  18.69100  1.000 93.81000  ? 24  ASN A HA   1 
ATOM   304  H HB2  . ASN A 1 24  ? 10.45200 -5.63100  18.12600  1.000 85.06000  ? 24  ASN A HB2  1 
ATOM   305  H HB3  . ASN A 1 24  ? 10.83500 -6.16300  19.57400  1.000 85.06000  ? 24  ASN A HB3  1 
ATOM   306  H HD21 . ASN A 1 24  ? 13.38900 -3.75500  19.94900  1.000 100.40000 ? 24  ASN A HD21 1 
ATOM   307  H HD22 . ASN A 1 24  ? 13.31300 -5.24200  19.98800  1.000 100.40000 ? 24  ASN A HD22 1 
ATOM   308  N N    . THR A 1 25  ? 10.92900 -8.60600  16.99800  1.000 80.54000  ? 25  THR A N    1 
ATOM   309  C CA   . THR A 1 25  ? 10.23300 -9.89000  16.95400  1.000 68.53000  ? 25  THR A CA   1 
ATOM   310  C C    . THR A 1 25  ? 11.05500 -11.09800 17.37300  1.000 70.23000  ? 25  THR A C    1 
ATOM   311  O O    . THR A 1 25  ? 12.29000 -11.07500 17.36100  1.000 88.54000  ? 25  THR A O    1 
ATOM   312  C CB   . THR A 1 25  ? 9.72000  -10.20200 15.54000  1.000 58.30000  ? 25  THR A CB   1 
ATOM   313  O OG1  . THR A 1 25  ? 9.24100  -9.01000  14.91900  1.000 89.08000  ? 25  THR A OG1  1 
ATOM   314  C CG2  . THR A 1 25  ? 8.60500  -11.24000 15.57700  1.000 82.48000  ? 25  THR A CG2  1 
ATOM   315  H H    . THR A 1 25  ? 10.89500 -8.15500  16.26700  1.000 96.52000  ? 25  THR A H    1 
ATOM   316  H HA   . THR A 1 25  ? 9.51100  -9.77700  17.59200  1.000 82.12000  ? 25  THR A HA   1 
ATOM   317  H HB   . THR A 1 25  ? 10.45100 -10.56400 15.01600  1.000 69.84000  ? 25  THR A HB   1 
ATOM   318  H HG1  . THR A 1 25  ? 8.87400  -9.19600  14.18600  1.000 106.77000 ? 25  THR A HG1  1 
ATOM   319  H HG21 . THR A 1 25  ? 8.27000  -11.39900 14.68100  1.000 98.85000  ? 25  THR A HG21 1 
ATOM   320  H HG22 . THR A 1 25  ? 8.94000  -12.07500 15.94000  1.000 98.85000  ? 25  THR A HG22 1 
ATOM   321  H HG23 . THR A 1 25  ? 7.87600  -10.92500 16.13400  1.000 98.85000  ? 25  THR A HG23 1 
ATOM   322  N N    . VAL A 1 26  ? 10.34200 -12.17000 17.69000  1.000 82.22000  ? 26  VAL A N    1 
ATOM   323  C CA   . VAL A 1 26  ? 10.94000 -13.41600 18.13600  1.000 86.31000  ? 26  VAL A CA   1 
ATOM   324  C C    . VAL A 1 26  ? 10.90100 -14.48800 17.06800  1.000 64.77000  ? 26  VAL A C    1 
ATOM   325  O O    . VAL A 1 26  ? 11.55000 -15.53100 17.25300  1.000 78.96000  ? 26  VAL A O    1 
ATOM   326  C CB   . VAL A 1 26  ? 10.24700 -13.92700 19.41300  1.000 102.57000 ? 26  VAL A CB   1 
ATOM   327  C CG1  . VAL A 1 26  ? 10.26200 -12.85600 20.46300  1.000 79.57000  ? 26  VAL A CG1  1 
ATOM   328  C CG2  . VAL A 1 26  ? 8.80000  -14.33900 19.11000  1.000 75.90000  ? 26  VAL A CG2  1 
ATOM   329  H H    . VAL A 1 26  ? 9.48300  -12.20100 17.65400  1.000 98.54000  ? 26  VAL A H    1 
ATOM   330  H HA   . VAL A 1 26  ? 11.87300 -13.25200 18.34800  1.000 103.44000 ? 26  VAL A HA   1 
ATOM   331  H HB   . VAL A 1 26  ? 10.72500 -14.70400 19.74500  1.000 122.96000 ? 26  VAL A HB   1 
ATOM   332  H HG11 . VAL A 1 26  ? 10.00600 -13.24400 21.31500  1.000 95.36000  ? 26  VAL A HG11 1 
ATOM   333  H HG12 . VAL A 1 26  ? 11.15600 -12.48500 20.52400  1.000 95.36000  ? 26  VAL A HG12 1 
ATOM   334  H HG13 . VAL A 1 26  ? 9.63200  -12.16100 20.21400  1.000 95.36000  ? 26  VAL A HG13 1 
ATOM   335  H HG21 . VAL A 1 26  ? 8.33100  -14.48300 19.94600  1.000 90.95000  ? 26  VAL A HG21 1 
ATOM   336  H HG22 . VAL A 1 26  ? 8.36900  -13.63000 18.60700  1.000 90.95000  ? 26  VAL A HG22 1 
ATOM   337  H HG23 . VAL A 1 26  ? 8.80700  -15.15700 18.58900  1.000 90.95000  ? 26  VAL A HG23 1 
ATOM   338  N N    . TYR A 1 27  ? 10.39300 -14.18400 15.87800  1.000 75.21000  ? 27  TYR A N    1 
ATOM   339  C CA   . TYR A 1 27  ? 10.19300 -15.16300 14.77900  1.000 74.30000  ? 27  TYR A CA   1 
ATOM   340  C C    . TYR A 1 27  ? 11.24000 -16.24700 14.81100  1.000 74.38000  ? 27  TYR A C    1 
ATOM   341  O O    . TYR A 1 27  ? 12.42400 -15.93700 14.88000  1.000 70.88000  ? 27  TYR A O    1 
ATOM   342  C CB   . TYR A 1 27  ? 10.17900 -14.37700 13.47100  1.000 76.78000  ? 27  TYR A CB   1 
ATOM   343  C CG   . TYR A 1 27  ? 9.90200  -15.21700 12.23700  1.000 83.79000  ? 27  TYR A CG   1 
ATOM   344  C CD1  . TYR A 1 27  ? 8.78800  -16.03800 12.17000  1.000 75.18000  ? 27  TYR A CD1  1 
ATOM   345  C CD2  . TYR A 1 27  ? 10.75300 -15.18600 11.14500  1.000 75.00000  ? 27  TYR A CD2  1 
ATOM   346  C CE1  . TYR A 1 27  ? 8.52900  -16.80700 11.05200  1.000 61.72000  ? 27  TYR A CE1  1 
ATOM   347  C CE2  . TYR A 1 27  ? 10.50100 -15.94800 10.02000  1.000 77.53000  ? 27  TYR A CE2  1 
ATOM   348  C CZ   . TYR A 1 27  ? 9.38700  -16.76100 9.97400   1.000 73.08000  ? 27  TYR A CZ   1 
ATOM   349  O OH   . TYR A 1 27  ? 9.13700  -17.52200 8.87400   1.000 72.50000  ? 27  TYR A OH   1 
ATOM   350  H H    . TYR A 1 27  ? 10.28300 -13.33400 15.61000  1.000 90.13000  ? 27  TYR A H    1 
ATOM   351  H HA   . TYR A 1 27  ? 9.30400  -15.58500 14.90000  1.000 89.03000  ? 27  TYR A HA   1 
ATOM   352  H HB2  . TYR A 1 27  ? 9.49400  -13.67500 13.53700  1.000 92.01000  ? 27  TYR A HB2  1 
ATOM   353  H HB3  . TYR A 1 27  ? 11.05100 -13.93600 13.36400  1.000 92.01000  ? 27  TYR A HB3  1 
ATOM   354  H HD1  . TYR A 1 27  ? 8.19900  -16.08000 12.90500  1.000 90.09000  ? 27  TYR A HD1  1 
ATOM   355  H HD2  . TYR A 1 27  ? 11.51600 -14.62900 11.16600  1.000 89.88000  ? 27  TYR A HD2  1 
ATOM   356  H HE1  . TYR A 1 27  ? 7.77800  -17.36700 11.03000  1.000 73.94000  ? 27  TYR A HE1  1 
ATOM   357  H HE2  . TYR A 1 27  ? 11.08500 -15.91200 9.28800   1.000 92.91000  ? 27  TYR A HE2  1 
ATOM   358  H HH   . TYR A 1 27  ? 8.41100  -17.96400 8.98300   1.000 86.88000  ? 27  TYR A HH   1 
ATOM   359  N N    . SER A 1 28  ? 10.83500 -17.49400 14.59400  1.000 78.70000  ? 28  SER A N    1 
ATOM   360  C CA   . SER A 1 28  ? 11.74900 -18.65300 14.70300  1.000 82.52000  ? 28  SER A CA   1 
ATOM   361  C C    . SER A 1 28  ? 12.55900 -18.87800 13.42300  1.000 89.82000  ? 28  SER A C    1 
ATOM   362  O O    . SER A 1 28  ? 13.76400 -19.14600 13.55500  1.000 86.03000  ? 28  SER A O    1 
ATOM   363  C CB   . SER A 1 28  ? 10.95600 -19.87200 15.04700  1.000 82.01000  ? 28  SER A CB   1 
ATOM   364  O OG   . SER A 1 28  ? 10.79000 -19.97300 16.45300  1.000 53.34000  ? 28  SER A OG   1 
ATOM   365  H H    . SER A 1 28  ? 9.98800  -17.69400 14.35500  1.000 94.32000  ? 28  SER A H    1 
ATOM   366  H HA   . SER A 1 28  ? 12.38200 -18.47900 15.44300  1.000 98.90000  ? 28  SER A HA   1 
ATOM   367  H HB2  . SER A 1 28  ? 10.08300 -19.82400 14.61600  1.000 98.29000  ? 28  SER A HB2  1 
ATOM   368  H HB3  . SER A 1 28  ? 11.42000 -20.66300 14.71400  1.000 98.29000  ? 28  SER A HB3  1 
ATOM   369  H HG   . SER A 1 28  ? 10.24200 -20.59700 16.61500  1.000 63.88000  ? 28  SER A HG   1 
ATOM   370  N N    . ASN A 1 29  ? 11.94400 -18.77600 12.25000  1.000 75.29000  ? 29  ASN A N    1 
ATOM   371  C CA   . ASN A 1 29  ? 12.63200 -19.06500 10.96600  1.000 74.14000  ? 29  ASN A CA   1 
ATOM   372  C C    . ASN A 1 29  ? 13.32300 -17.79400 10.46700  1.000 85.28000  ? 29  ASN A C    1 
ATOM   373  O O    . ASN A 1 29  ? 13.06600 -17.42100 9.33400   1.000 67.21000  ? 29  ASN A O    1 
ATOM   374  C CB   . ASN A 1 29  ? 11.64500 -19.68900 9.98900   1.000 64.77000  ? 29  ASN A CB   1 
ATOM   375  C CG   . ASN A 1 29  ? 12.31700 -20.46100 8.88200   1.000 63.06000  ? 29  ASN A CG   1 
ATOM   376  O OD1  . ASN A 1 29  ? 13.19900 -21.28800 9.13600   1.000 57.39000  ? 29  ASN A OD1  1 
ATOM   377  N ND2  . ASN A 1 29  ? 11.90100 -20.21700 7.65100   1.000 54.22000  ? 29  ASN A ND2  1 
ATOM   378  H H    . ASN A 1 29  ? 11.08400 -18.50900 12.19000  1.000 90.22000  ? 29  ASN A H    1 
ATOM   379  H HA   . ASN A 1 29  ? 13.32700 -19.73400 11.14100  1.000 88.84000  ? 29  ASN A HA   1 
ATOM   380  H HB2  . ASN A 1 29  ? 11.05400 -20.29200 10.48100  1.000 77.60000  ? 29  ASN A HB2  1 
ATOM   381  H HB3  . ASN A 1 29  ? 11.09400 -18.98800 9.59700   1.000 77.60000  ? 29  ASN A HB3  1 
ATOM   382  H HD21 . ASN A 1 29  ? 12.43300 -20.38800 6.96200   1.000 64.94000  ? 29  ASN A HD21 1 
ATOM   383  H HD22 . ASN A 1 29  ? 11.09700 -19.86500 7.51900   1.000 64.94000  ? 29  ASN A HD22 1 
ATOM   384  N N    . LYS A 1 30  ? 14.23700 -17.22000 11.24700  1.000 69.25000  ? 30  LYS A N    1 
ATOM   385  C CA   . LYS A 1 30  ? 14.90400 -15.93900 10.91400  1.000 65.51000  ? 30  LYS A CA   1 
ATOM   386  C C    . LYS A 1 30  ? 15.78100 -16.08700 9.66500   1.000 72.60000  ? 30  LYS A C    1 
ATOM   387  O O    . LYS A 1 30  ? 16.02300 -15.05100 9.05900   1.000 52.59000  ? 30  LYS A O    1 
ATOM   388  C CB   . LYS A 1 30  ? 15.71400 -15.44500 12.11300  1.000 58.22000  ? 30  LYS A CB   1 
ATOM   389  C CG   . LYS A 1 30  ? 14.95400 -14.62500 13.12400  1.000 50.83000  ? 30  LYS A CG   1 
ATOM   390  C CD   . LYS A 1 30  ? 15.78800 -14.29000 14.35200  1.000 63.97000  ? 30  LYS A CD   1 
ATOM   391  C CE   . LYS A 1 30  ? 14.99600 -13.67900 15.45700  1.000 60.77000  ? 30  LYS A CE   1 
ATOM   392  N NZ   . LYS A 1 30  ? 14.94100 -12.22400 15.34000  1.000 64.82000  ? 30  LYS A NZ   1 
ATOM   393  H H    . LYS A 1 30  ? 14.50300 -17.60300 12.01800  1.000 82.98000  ? 30  LYS A H    1 
ATOM   394  H HA   . LYS A 1 30  ? 14.20100 -15.26700 10.72200  1.000 78.48000  ? 30  LYS A HA   1 
ATOM   395  H HB2  . LYS A 1 30  ? 16.09500 -16.22200 12.57200  1.000 69.74000  ? 30  LYS A HB2  1 
ATOM   396  H HB3  . LYS A 1 30  ? 16.46100 -14.90300 11.78200  1.000 69.74000  ? 30  LYS A HB3  1 
ATOM   397  H HG2  . LYS A 1 30  ? 14.65500 -13.79600 12.70100  1.000 60.88000  ? 30  LYS A HG2  1 
ATOM   398  H HG3  . LYS A 1 30  ? 14.16300 -15.12600 13.39600  1.000 60.88000  ? 30  LYS A HG3  1 
ATOM   399  H HD2  . LYS A 1 30  ? 16.21100 -15.11200 14.67900  1.000 76.64000  ? 30  LYS A HD2  1 
ATOM   400  H HD3  . LYS A 1 30  ? 16.50100 -13.67100 14.09000  1.000 76.64000  ? 30  LYS A HD3  1 
ATOM   401  H HE2  . LYS A 1 30  ? 14.08800 -14.02700 15.43700  1.000 72.81000  ? 30  LYS A HE2  1 
ATOM   402  H HE3  . LYS A 1 30  ? 15.39700 -13.91400 16.31300  1.000 72.81000  ? 30  LYS A HE3  1 
ATOM   403  H HZ1  . LYS A 1 30  ? 14.35200 -11.88600 15.93800  1.000 77.66000  ? 30  LYS A HZ1  1 
ATOM   404  H HZ2  . LYS A 1 30  ? 15.76400 -11.87400 15.49100  1.000 77.66000  ? 30  LYS A HZ2  1 
ATOM   405  H HZ3  . LYS A 1 30  ? 14.67900 -12.00000 14.50000  1.000 77.66000  ? 30  LYS A HZ3  1 
ATOM   406  N N    . GLU A 1 31  ? 16.20800 -17.29700 9.28200   1.000 61.91000  ? 31  GLU A N    1 
ATOM   407  C CA   . GLU A 1 31  ? 16.95900 -17.50900 8.05200   1.000 54.81000  ? 31  GLU A CA   1 
ATOM   408  C C    . GLU A 1 31  ? 16.30300 -17.00500 6.76200   1.000 47.49000  ? 31  GLU A C    1 
ATOM   409  O O    . GLU A 1 31  ? 16.90200 -17.02800 5.66000   1.000 51.31000  ? 31  GLU A O    1 
ATOM   410  C CB   . GLU A 1 31  ? 17.23400 -19.02400 7.91000   1.000 76.19000  ? 31  GLU A CB   1 
ATOM   411  C CG   . GLU A 1 31  ? 15.98900 -19.86000 7.45300   1.000 83.39000  ? 31  GLU A CG   1 
ATOM   412  C CD   . GLU A 1 31  ? 16.29500 -21.31600 7.20700   1.000 80.63000  ? 31  GLU A CD   1 
ATOM   413  O OE1  . GLU A 1 31  ? 17.13700 -21.84700 7.96800   1.000 66.61000  ? 31  GLU A OE1  1 
ATOM   414  O OE2  . GLU A 1 31  ? 15.69000 -21.91600 6.27500   1.000 91.30000  ? 31  GLU A OE2  1 
ATOM   415  H H    . GLU A 1 31  ? 16.09100 -18.00900 9.75000   1.000 74.16000  ? 31  GLU A H    1 
ATOM   416  H HA   . GLU A 1 31  ? 17.77100 -16.98400 8.13500   1.000 65.65000  ? 31  GLU A HA   1 
ATOM   417  H HB2  . GLU A 1 31  ? 17.93400 -19.15200 7.25000   1.000 91.30000  ? 31  GLU A HB2  1 
ATOM   418  H HB3  . GLU A 1 31  ? 17.52200 -19.37000 8.76900   1.000 91.30000  ? 31  GLU A HB3  1 
ATOM   419  H HG2  . GLU A 1 31  ? 15.31000 -19.81200 8.14300   1.000 99.94000  ? 31  GLU A HG2  1 
ATOM   420  H HG3  . GLU A 1 31  ? 15.64800 -19.48500 6.62500   1.000 99.94000  ? 31  GLU A HG3  1 
ATOM   421  N N    . ILE A 1 32  ? 15.05600 -16.56700 6.84900   1.000 57.36000  ? 32  ILE A N    1 
ATOM   422  C CA   . ILE A 1 32  ? 14.43200 -16.19000 5.58500   1.000 43.58000  ? 32  ILE A CA   1 
ATOM   423  C C    . ILE A 1 32  ? 15.01900 -14.89100 5.02700   1.000 54.33000  ? 32  ILE A C    1 
ATOM   424  O O    . ILE A 1 32  ? 14.82500 -14.57500 3.83000   1.000 51.01000  ? 32  ILE A O    1 
ATOM   425  C CB   . ILE A 1 32  ? 12.90100 -16.11700 5.73800   1.000 55.10000  ? 32  ILE A CB   1 
ATOM   426  C CG1  . ILE A 1 32  ? 12.43600 -15.33800 6.98100   1.000 64.67000  ? 32  ILE A CG1  1 
ATOM   427  C CG2  . ILE A 1 32  ? 12.29100 -17.52500 5.76200   1.000 73.77000  ? 32  ILE A CG2  1 
ATOM   428  C CD1  . ILE A 1 32  ? 12.55500 -13.81500 6.92600   1.000 66.89000  ? 32  ILE A CD1  1 
ATOM   429  H H    . ILE A 1 32  ? 14.58600 -16.48500 7.56400   1.000 68.71000  ? 32  ILE A H    1 
ATOM   430  H HA   . ILE A 1 32  ? 14.61800 -16.88200 4.93200   1.000 52.18000  ? 32  ILE A HA   1 
ATOM   431  H HB   . ILE A 1 32  ? 12.58800 -15.62400 4.96300   1.000 66.00000  ? 32  ILE A HB   1 
ATOM   432  H HG12 . ILE A 1 32  ? 11.50100 -15.54400 7.13200   1.000 77.48000  ? 32  ILE A HG12 1 
ATOM   433  H HG13 . ILE A 1 32  ? 12.96700 -15.63500 7.73700   1.000 77.48000  ? 32  ILE A HG13 1 
ATOM   434  H HG21 . ILE A 1 32  ? 11.32500 -17.45000 5.81300   1.000 88.41000  ? 32  ILE A HG21 1 
ATOM   435  H HG22 . ILE A 1 32  ? 12.54300 -17.99200 4.95000   1.000 88.41000  ? 32  ILE A HG22 1 
ATOM   436  H HG23 . ILE A 1 32  ? 12.62700 -18.00200 6.53600   1.000 88.41000  ? 32  ILE A HG23 1 
ATOM   437  H HD11 . ILE A 1 32  ? 11.87300 -13.42400 7.49400   1.000 80.15000  ? 32  ILE A HD11 1 
ATOM   438  H HD12 . ILE A 1 32  ? 13.43500 -13.55500 7.23900   1.000 80.15000  ? 32  ILE A HD12 1 
ATOM   439  H HD13 . ILE A 1 32  ? 12.42900 -13.52200 6.01000   1.000 80.15000  ? 32  ILE A HD13 1 
ATOM   440  N N    . PHE A 1 33  ? 15.70700 -14.11300 5.87700   1.000 66.14000  ? 33  PHE A N    1 
ATOM   441  C CA   . PHE A 1 33  ? 16.25500 -12.83600 5.44200   1.000 46.91000  ? 33  PHE A CA   1 
ATOM   442  C C    . PHE A 1 33  ? 17.09900 -13.01100 4.19000   1.000 49.88000  ? 33  PHE A C    1 
ATOM   443  O O    . PHE A 1 33  ? 17.07500 -12.16300 3.28100   1.000 36.25000  ? 33  PHE A O    1 
ATOM   444  C CB   . PHE A 1 33  ? 17.05600 -12.19000 6.58300   1.000 51.87000  ? 33  PHE A CB   1 
ATOM   445  C CG   . PHE A 1 33  ? 18.45000 -12.69200 6.71300   1.000 48.13000  ? 33  PHE A CG   1 
ATOM   446  C CD1  . PHE A 1 33  ? 18.72600 -13.81000 7.48700   1.000 46.02000  ? 33  PHE A CD1  1 
ATOM   447  C CD2  . PHE A 1 33  ? 19.48300 -12.04000 6.05400   1.000 54.99000  ? 33  PHE A CD2  1 
ATOM   448  C CE1  . PHE A 1 33  ? 20.00400 -14.26600 7.61400   1.000 48.63000  ? 33  PHE A CE1  1 
ATOM   449  C CE2  . PHE A 1 33  ? 20.77000 -12.49100 6.14800   1.000 45.82000  ? 33  PHE A CE2  1 
ATOM   450  C CZ   . PHE A 1 33  ? 21.05100 -13.58300 6.94000   1.000 43.82000  ? 33  PHE A CZ   1 
ATOM   451  H H    . PHE A 1 33  ? 15.86400 -14.30500 6.70000   1.000 79.24000  ? 33  PHE A H    1 
ATOM   452  H HA   . PHE A 1 33  ? 15.53200 -12.22700 5.22600   1.000 56.17000  ? 33  PHE A HA   1 
ATOM   453  H HB2  . PHE A 1 33  ? 17.10200 -11.23400 6.42600   1.000 62.12000  ? 33  PHE A HB2  1 
ATOM   454  H HB3  . PHE A 1 33  ? 16.60100 -12.36700 7.42000   1.000 62.12000  ? 33  PHE A HB3  1 
ATOM   455  H HD1  . PHE A 1 33  ? 18.03400 -14.25200 7.92300   1.000 55.10000  ? 33  PHE A HD1  1 
ATOM   456  H HD2  . PHE A 1 33  ? 19.29700 -11.28600 5.54200   1.000 65.86000  ? 33  PHE A HD2  1 
ATOM   457  H HE1  . PHE A 1 33  ? 20.18800 -15.01400 8.13400   1.000 58.23000  ? 33  PHE A HE1  1 
ATOM   458  H HE2  . PHE A 1 33  ? 21.45100 -12.06400 5.68100   1.000 54.86000  ? 33  PHE A HE2  1 
ATOM   459  H HZ   . PHE A 1 33  ? 21.92900 -13.87400 7.03400   1.000 52.46000  ? 33  PHE A HZ   1 
ATOM   460  N N    . LEU A 1 34  ? 17.82100 -14.13400 4.10100   1.000 41.43000  ? 34  LEU A N    1 
ATOM   461  C CA   . LEU A 1 34  ? 18.73700 -14.31800 2.98600   1.000 41.84000  ? 34  LEU A CA   1 
ATOM   462  C C    . LEU A 1 34  ? 18.00300 -14.53400 1.67000   1.000 43.42000  ? 34  LEU A C    1 
ATOM   463  O O    . LEU A 1 34  ? 18.39400 -13.96100 0.64700   1.000 42.57000  ? 34  LEU A O    1 
ATOM   464  C CB   . LEU A 1 34  ? 19.67500 -15.47500 3.24600   1.000 49.19000  ? 34  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 34  ? 20.97500 -15.33600 2.46300   1.000 47.90000  ? 34  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 34  ? 21.78600 -14.09900 2.79500   1.000 55.97000  ? 34  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 34  ? 21.77500 -16.57100 2.75800   1.000 53.74000  ? 34  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 34  ? 17.79600 -14.78600 4.66100   1.000 49.60000  ? 34  LEU A H    1 
ATOM   469  H HA   . LEU A 1 34  ? 19.26600 -13.50800 2.90900   1.000 50.08000  ? 34  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 34  ? 19.89000 -15.50500 4.19100   1.000 58.90000  ? 34  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 34  ? 19.24400 -16.30100 2.97700   1.000 58.90000  ? 34  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 34  ? 20.76600 -15.23600 1.52100   1.000 57.36000  ? 34  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 34  ? 22.69700 -14.22800 2.48800   1.000 67.04000  ? 34  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 34  ? 21.39100 -13.33400 2.34800   1.000 67.04000  ? 34  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 34  ? 21.77600 -13.96300 3.75500   1.000 67.04000  ? 34  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 34  ? 22.59800 -16.54300 2.24500   1.000 64.36000  ? 34  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 34  ? 21.97700 -16.59800 3.70600   1.000 64.36000  ? 34  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 34  ? 21.25600 -17.35100 2.50800   1.000 64.36000  ? 34  LEU A HD23 1 
ATOM   479  N N    . ARG A 1 35  ? 16.94100 -15.35500 1.66600   1.000 44.00000  ? 35  ARG A N    1 
ATOM   480  C CA   . ARG A 1 35  ? 16.07900 -15.47400 0.46800   1.000 42.95000  ? 35  ARG A CA   1 
ATOM   481  C C    . ARG A 1 35  ? 15.64500 -14.08900 -0.02100  1.000 40.60000  ? 35  ARG A C    1 
ATOM   482  O O    . ARG A 1 35  ? 15.76800 -13.75600 -1.20600  1.000 42.63000  ? 35  ARG A O    1 
ATOM   483  C CB   . ARG A 1 35  ? 14.83600 -16.34800 0.77100   1.000 54.14000  ? 35  ARG A CB   1 
ATOM   484  C CG   . ARG A 1 35  ? 13.80200 -16.34900 -0.37800  1.000 87.38000  ? 35  ARG A CG   1 
ATOM   485  C CD   . ARG A 1 35  ? 12.35500 -16.55900 0.04300   1.000 75.55000  ? 35  ARG A CD   1 
ATOM   486  N NE   . ARG A 1 35  ? 11.90100 -17.89800 -0.31500  1.000 95.59000  ? 35  ARG A NE   1 
ATOM   487  C CZ   . ARG A 1 35  ? 11.12200 -18.65500 0.44800   1.000 110.70000 ? 35  ARG A CZ   1 
ATOM   488  N NH1  . ARG A 1 35  ? 10.70000 -18.23300 1.62700   1.000 98.52000  ? 35  ARG A NH1  1 
ATOM   489  N NH2  . ARG A 1 35  ? 10.81600 -19.89200 0.04800   1.000 96.30000  ? 35  ARG A NH2  1 
ATOM   490  H H    . ARG A 1 35  ? 16.69800 -15.84600 2.32900   1.000 52.68000  ? 35  ARG A H    1 
ATOM   491  H HA   . ARG A 1 35  ? 16.58500 -15.91400 -0.23400  1.000 51.42000  ? 35  ARG A HA   1 
ATOM   492  H HB2  . ARG A 1 35  ? 15.12300 -17.26400 0.91600   1.000 64.84000  ? 35  ARG A HB2  1 
ATOM   493  H HB3  . ARG A 1 35  ? 14.39900 -16.00800 1.56700   1.000 64.84000  ? 35  ARG A HB3  1 
ATOM   494  H HG2  . ARG A 1 35  ? 13.84800 -15.49300 -0.83200  1.000 104.74000 ? 35  ARG A HG2  1 
ATOM   495  H HG3  . ARG A 1 35  ? 14.02900 -17.06400 -0.99400  1.000 104.74000 ? 35  ARG A HG3  1 
ATOM   496  H HD2  . ARG A 1 35  ? 12.27900 -16.45500 1.00500   1.000 90.53000  ? 35  ARG A HD2  1 
ATOM   497  H HD3  . ARG A 1 35  ? 11.78900 -15.91200 -0.40600  1.000 90.53000  ? 35  ARG A HD3  1 
ATOM   498  H HE   . ARG A 1 35  ? 12.15600 -18.21900 -1.07100  1.000 114.59000 ? 35  ARG A HE   1 
ATOM   499  H HH11 . ARG A 1 35  ? 10.93000 -17.45500 1.91300   1.000 118.10000 ? 35  ARG A HH11 1 
ATOM   500  H HH12 . ARG A 1 35  ? 10.19500 -18.73600 2.10900   1.000 118.10000 ? 35  ARG A HH12 1 
ATOM   501  H HH21 . ARG A 1 35  ? 11.12400 -20.19100 -0.69700  1.000 115.43000 ? 35  ARG A HH21 1 
ATOM   502  H HH22 . ARG A 1 35  ? 10.31200 -20.38900 0.53600   1.000 115.43000 ? 35  ARG A HH22 1 
ATOM   503  N N    . GLU A 1 36  ? 15.15800 -13.26800 0.91100   1.000 44.53000  ? 36  GLU A N    1 
ATOM   504  C CA   . GLU A 1 36  ? 14.65800 -11.93300 0.59500   1.000 38.35000  ? 36  GLU A CA   1 
ATOM   505  C C    . GLU A 1 36  ? 15.71900 -11.02800 -0.02000  1.000 45.48000  ? 36  GLU A C    1 
ATOM   506  O O    . GLU A 1 36  ? 15.46200 -10.37100 -1.04100  1.000 37.47000  ? 36  GLU A O    1 
ATOM   507  C CB   . GLU A 1 36  ? 14.06400 -11.31300 1.86700   1.000 33.04000  ? 36  GLU A CB   1 
ATOM   508  C CG   . GLU A 1 36  ? 12.93600 -12.14200 2.43300   1.000 51.07000  ? 36  GLU A CG   1 
ATOM   509  C CD   . GLU A 1 36  ? 11.78700 -12.38200 1.41500   1.000 49.11000  ? 36  GLU A CD   1 
ATOM   510  O OE1  . GLU A 1 36  ? 11.47600 -11.45600 0.61300   1.000 48.47000  ? 36  GLU A OE1  1 
ATOM   511  O OE2  . GLU A 1 36  ? 11.22900 -13.52700 1.42700   1.000 61.74000  ? 36  GLU A OE2  1 
ATOM   512  H H    . GLU A 1 36  ? 15.10600 -13.46300 1.74700   1.000 53.31000  ? 36  GLU A H    1 
ATOM   513  H HA   . GLU A 1 36  ? 13.96200 -12.01700 -0.07500  1.000 45.89000  ? 36  GLU A HA   1 
ATOM   514  H HB2  . GLU A 1 36  ? 14.75700 -11.24400 2.54100   1.000 39.53000  ? 36  GLU A HB2  1 
ATOM   515  H HB3  . GLU A 1 36  ? 13.71600 -10.43100 1.65700   1.000 39.53000  ? 36  GLU A HB3  1 
ATOM   516  H HG2  . GLU A 1 36  ? 13.28400 -13.00700 2.70000   1.000 61.15000  ? 36  GLU A HG2  1 
ATOM   517  H HG3  . GLU A 1 36  ? 12.56200 -11.68300 3.20200   1.000 61.15000  ? 36  GLU A HG3  1 
ATOM   518  N N    . LEU A 1 37  ? 16.91900 -10.97200 0.58800   1.000 33.81000  ? 37  LEU A N    1 
ATOM   519  C CA   . LEU A 1 37  ? 17.97100 -10.09800 0.04000   1.000 46.62000  ? 37  LEU A CA   1 
ATOM   520  C C    . LEU A 1 37  ? 18.48600 -10.62800 -1.28900  1.000 39.35000  ? 37  LEU A C    1 
ATOM   521  O O    . LEU A 1 37  ? 18.81600 -9.85700  -2.20400  1.000 31.45000  ? 37  LEU A O    1 
ATOM   522  C CB   . LEU A 1 37  ? 19.14500 -9.93200  1.03300   1.000 34.78000  ? 37  LEU A CB   1 
ATOM   523  C CG   . LEU A 1 37  ? 18.64000 -9.35500  2.37000   1.000 34.18000  ? 37  LEU A CG   1 
ATOM   524  C CD1  . LEU A 1 37  ? 19.59900 -9.30700  3.46200   1.000 38.09000  ? 37  LEU A CD1  1 
ATOM   525  C CD2  . LEU A 1 37  ? 17.98300 -7.90000  2.18700   1.000 46.02000  ? 37  LEU A CD2  1 
ATOM   526  H H    . LEU A 1 37  ? 17.14000 -11.41300 1.29300   1.000 40.45000  ? 37  LEU A H    1 
ATOM   527  H HA   . LEU A 1 37  ? 17.58300 -9.22000  -0.09900  1.000 55.83000  ? 37  LEU A HA   1 
ATOM   528  H HB2  . LEU A 1 37  ? 19.55200 -10.79600 1.20200   1.000 41.62000  ? 37  LEU A HB2  1 
ATOM   529  H HB3  . LEU A 1 37  ? 19.80200 -9.32300  0.66100   1.000 41.62000  ? 37  LEU A HB3  1 
ATOM   530  H HG   . LEU A 1 37  ? 17.96900 -9.99900  2.64600   1.000 40.89000  ? 37  LEU A HG   1 
ATOM   531  H HD11 . LEU A 1 37  ? 19.15800 -8.96800  4.25600   1.000 45.58000  ? 37  LEU A HD11 1 
ATOM   532  H HD12 . LEU A 1 37  ? 19.93400 -10.20300 3.62800   1.000 45.58000  ? 37  LEU A HD12 1 
ATOM   533  H HD13 . LEU A 1 37  ? 20.33100 -8.72100  3.21400   1.000 45.58000  ? 37  LEU A HD13 1 
ATOM   534  H HD21 . LEU A 1 37  ? 17.90100 -7.47900  3.05700   1.000 55.11000  ? 37  LEU A HD21 1 
ATOM   535  H HD22 . LEU A 1 37  ? 18.55500 -7.36600  1.61300   1.000 55.11000  ? 37  LEU A HD22 1 
ATOM   536  H HD23 . LEU A 1 37  ? 17.10700 -7.99800  1.78300   1.000 55.11000  ? 37  LEU A HD23 1 
ATOM   537  N N    . ILE A 1 38  ? 18.56300 -11.94600 -1.41800  1.000 32.68000  ? 38  ILE A N    1 
ATOM   538  C CA   . ILE A 1 38  ? 18.99900 -12.51200 -2.68100  1.000 37.94000  ? 38  ILE A CA   1 
ATOM   539  C C    . ILE A 1 38  ? 17.98200 -12.19700 -3.75500  1.000 35.49000  ? 38  ILE A C    1 
ATOM   540  O O    . ILE A 1 38  ? 18.33500 -11.92600 -4.91000  1.000 36.89000  ? 38  ILE A O    1 
ATOM   541  C CB   . ILE A 1 38  ? 19.23200 -14.02300 -2.53500  1.000 46.64000  ? 38  ILE A CB   1 
ATOM   542  C CG1  . ILE A 1 38  ? 20.49200 -14.32000 -1.72300  1.000 46.28000  ? 38  ILE A CG1  1 
ATOM   543  C CG2  . ILE A 1 38  ? 19.36000 -14.64900 -3.88600  1.000 46.57000  ? 38  ILE A CG2  1 
ATOM   544  C CD1  . ILE A 1 38  ? 20.59100 -15.80500 -1.31600  1.000 43.66000  ? 38  ILE A CD1  1 
ATOM   545  H H    . ILE A 1 38  ? 18.37300 -12.51800 -0.80500  1.000 39.10000  ? 38  ILE A H    1 
ATOM   546  H HA   . ILE A 1 38  ? 19.84500 -12.11100 -2.93600  1.000 45.41000  ? 38  ILE A HA   1 
ATOM   547  H HB   . ILE A 1 38  ? 18.46900 -14.39400 -2.06400  1.000 55.84000  ? 38  ILE A HB   1 
ATOM   548  H HG12 . ILE A 1 38  ? 21.27200 -14.10000 -2.25600  1.000 55.41000  ? 38  ILE A HG12 1 
ATOM   549  H HG13 . ILE A 1 38  ? 20.48200 -13.78400 -0.91400  1.000 55.41000  ? 38  ILE A HG13 1 
ATOM   550  H HG21 . ILE A 1 38  ? 19.73100 -15.54000 -3.78700  1.000 55.76000  ? 38  ILE A HG21 1 
ATOM   551  H HG22 . ILE A 1 38  ? 18.48200 -14.70000 -4.29400  1.000 55.76000  ? 38  ILE A HG22 1 
ATOM   552  H HG23 . ILE A 1 38  ? 19.94800 -14.10400 -4.43200  1.000 55.76000  ? 38  ILE A HG23 1 
ATOM   553  H HD11 . ILE A 1 38  ? 21.24600 -15.89500 -0.60600  1.000 52.27000  ? 38  ILE A HD11 1 
ATOM   554  H HD12 . ILE A 1 38  ? 19.72300 -16.10600 -1.00500  1.000 52.27000  ? 38  ILE A HD12 1 
ATOM   555  H HD13 . ILE A 1 38  ? 20.86500 -16.32700 -2.08700  1.000 52.27000  ? 38  ILE A HD13 1 
ATOM   556  N N    . SER A 1 39  ? 16.69900 -12.20400 -3.36700  1.000 38.35000  ? 39  SER A N    1 
ATOM   557  C CA   . SER A 1 39  ? 15.61900 -11.98800 -4.32300  1.000 45.35000  ? 39  SER A CA   1 
ATOM   558  C C    . SER A 1 39  ? 15.66200 -10.55800 -4.83800  1.000 47.31000  ? 39  SER A C    1 
ATOM   559  O O    . SER A 1 39  ? 15.47600 -10.34800 -6.04600  1.000 41.35000  ? 39  SER A O    1 
ATOM   560  C CB   . SER A 1 39  ? 14.24300 -12.32100 -3.70800  1.000 45.56000  ? 39  SER A CB   1 
ATOM   561  O OG   . SER A 1 39  ? 13.28500 -11.28500 -4.06200  1.000 64.67000  ? 39  SER A OG   1 
ATOM   562  H H    . SER A 1 39  ? 16.43400 -12.33200 -2.55900  1.000 45.90000  ? 39  SER A H    1 
ATOM   563  H HA   . SER A 1 39  ? 15.73300 -12.59600 -5.07000  1.000 54.30000  ? 39  SER A HA   1 
ATOM   564  H HB2  . SER A 1 39  ? 13.93500 -13.17400 -4.05300  1.000 54.55000  ? 39  SER A HB2  1 
ATOM   565  H HB3  . SER A 1 39  ? 14.32500 -12.36500 -2.74200  1.000 54.55000  ? 39  SER A HB3  1 
ATOM   566  H HG   . SER A 1 39  ? 13.42800 -10.59400 -3.60600  1.000 77.49000  ? 39  SER A HG   1 
ATOM   567  N N    . ASN A 1 40  ? 15.98100 -9.58800  -3.94300  1.000 32.30000  ? 40  ASN A N    1 
ATOM   568  C CA   . ASN A 1 40  ? 16.18400 -8.19800  -4.33300  1.000 39.15000  ? 40  ASN A CA   1 
ATOM   569  C C    . ASN A 1 40  ? 17.40800 -8.06200  -5.21100  1.000 40.71000  ? 40  ASN A C    1 
ATOM   570  O O    . ASN A 1 40  ? 17.39900 -7.31600  -6.20500  1.000 37.88000  ? 40  ASN A O    1 
ATOM   571  C CB   . ASN A 1 40  ? 16.34900 -7.33100  -3.09400  1.000 42.75000  ? 40  ASN A CB   1 
ATOM   572  C CG   . ASN A 1 40  ? 15.04300 -7.18900  -2.27100  1.000 34.16000  ? 40  ASN A CG   1 
ATOM   573  O OD1  . ASN A 1 40  ? 13.97100 -7.64600  -2.66500  1.000 46.85000  ? 40  ASN A OD1  1 
ATOM   574  N ND2  . ASN A 1 40  ? 15.14300 -6.48800  -1.13500  1.000 47.51000  ? 40  ASN A ND2  1 
ATOM   575  H H    . ASN A 1 40  ? 16.08300 -9.72400  -3.10000  1.000 38.64000  ? 40  ASN A H    1 
ATOM   576  H HA   . ASN A 1 40  ? 15.40600 -7.89300  -4.82500  1.000 46.86000  ? 40  ASN A HA   1 
ATOM   577  H HB2  . ASN A 1 40  ? 17.02200 -7.72800  -2.52000  1.000 51.18000  ? 40  ASN A HB2  1 
ATOM   578  H HB3  . ASN A 1 40  ? 16.62800 -6.44300  -3.36700  1.000 51.18000  ? 40  ASN A HB3  1 
ATOM   579  H HD21 . ASN A 1 40  ? 14.45200 -6.37500  -0.63600  1.000 56.89000  ? 40  ASN A HD21 1 
ATOM   580  H HD22 . ASN A 1 40  ? 15.89900 -6.14900  -0.90400  1.000 56.89000  ? 40  ASN A HD22 1 
ATOM   581  N N    . ALA A 1 41  ? 18.48300 -8.79300  -4.87700  1.000 40.64000  ? 41  ALA A N    1 
ATOM   582  C CA   . ALA A 1 41  ? 19.68100 -8.66300  -5.69200  1.000 49.49000  ? 41  ALA A CA   1 
ATOM   583  C C    . ALA A 1 41  ? 19.42000 -9.22900  -7.08700  1.000 37.37000  ? 41  ALA A C    1 
ATOM   584  O O    . ALA A 1 41  ? 19.79600 -8.61200  -8.09500  1.000 47.16000  ? 41  ALA A O    1 
ATOM   585  C CB   . ALA A 1 41  ? 20.86600 -9.32100  -4.99500  1.000 36.00000  ? 41  ALA A CB   1 
ATOM   586  H H    . ALA A 1 41  ? 18.53500 -9.34000  -4.21600  1.000 48.65000  ? 41  ALA A H    1 
ATOM   587  H HA   . ALA A 1 41  ? 19.92400 -7.73000  -5.79600  1.000 59.26000  ? 41  ALA A HA   1 
ATOM   588  H HB1  . ALA A 1 41  ? 21.60300 -9.38900  -5.62200  1.000 43.08000  ? 41  ALA A HB1  1 
ATOM   589  H HB2  . ALA A 1 41  ? 21.12800 -8.77700  -4.23500  1.000 43.08000  ? 41  ALA A HB2  1 
ATOM   590  H HB3  . ALA A 1 41  ? 20.60500 -10.20500 -4.69400  1.000 43.08000  ? 41  ALA A HB3  1 
ATOM   591  N N    . SER A 1 42  ? 18.74600 -10.39300 -7.15600  1.000 49.70000  ? 42  SER A N    1 
ATOM   592  C CA   . SER A 1 42  ? 18.36100 -10.96800 -8.44300  1.000 50.57000  ? 42  SER A CA   1 
ATOM   593  C C    . SER A 1 42  ? 17.45700 -10.02900 -9.23900  1.000 48.60000  ? 42  SER A C    1 
ATOM   594  O O    . SER A 1 42  ? 17.59600 -9.91700  -10.45600 1.000 48.77000  ? 42  SER A O    1 
ATOM   595  C CB   . SER A 1 42  ? 17.65300 -12.29500 -8.25000  1.000 43.47000  ? 42  SER A CB   1 
ATOM   596  O OG   . SER A 1 42  ? 17.10200 -12.65400 -9.47900  1.000 48.45000  ? 42  SER A OG   1 
ATOM   597  H H    . SER A 1 42  ? 18.50500 -10.86000 -6.47600  1.000 59.52000  ? 42  SER A H    1 
ATOM   598  H HA   . SER A 1 42  ? 19.17600 -11.11900 -8.94600  1.000 60.57000  ? 42  SER A HA   1 
ATOM   599  H HB2  . SER A 1 42  ? 18.28800 -12.97000 -7.96400  1.000 52.05000  ? 42  SER A HB2  1 
ATOM   600  H HB3  . SER A 1 42  ? 16.94900 -12.20100 -7.58800  1.000 52.05000  ? 42  SER A HB3  1 
ATOM   601  H HG   . SER A 1 42  ? 17.71000 -12.74200 -10.05200 1.000 58.02000  ? 42  SER A HG   1 
ATOM   602  N N    . ASP A 1 43  ? 16.54000 -9.32600  -8.57200  1.000 44.94000  ? 43  ASP A N    1 
ATOM   603  C CA   . ASP A 1 43  ? 15.69500 -8.39000  -9.30800  1.000 45.00000  ? 43  ASP A CA   1 
ATOM   604  C C    . ASP A 1 43  ? 16.51000 -7.21900  -9.80100  1.000 51.68000  ? 43  ASP A C    1 
ATOM   605  O O    . ASP A 1 43  ? 16.26000 -6.69400  -10.88400 1.000 43.98000  ? 43  ASP A O    1 
ATOM   606  C CB   . ASP A 1 43  ? 14.55100 -7.84500  -8.44200  1.000 44.34000  ? 43  ASP A CB   1 
ATOM   607  C CG   . ASP A 1 43  ? 13.55100 -8.85100  -8.09700  1.000 46.48000  ? 43  ASP A CG   1 
ATOM   608  O OD1  . ASP A 1 43  ? 13.56400 -9.93600  -8.73000  1.000 58.90000  ? 43  ASP A OD1  1 
ATOM   609  O OD2  . ASP A 1 43  ? 12.81900 -8.55200  -7.12000  1.000 53.21000  ? 43  ASP A OD2  1 
ATOM   610  H H    . ASP A 1 43  ? 16.39400 -9.37000  -7.72600  1.000 53.81000  ? 43  ASP A H    1 
ATOM   611  H HA   . ASP A 1 43  ? 15.30600 -8.87900  -10.04900 1.000 53.88000  ? 43  ASP A HA   1 
ATOM   612  H HB2  . ASP A 1 43  ? 14.92100 -7.49900  -7.61500  1.000 53.09000  ? 43  ASP A HB2  1 
ATOM   613  H HB3  . ASP A 1 43  ? 14.10200 -7.13500  -8.92700  1.000 53.09000  ? 43  ASP A HB3  1 
ATOM   614  N N    . ALA A 1 44  ? 17.45500 -6.75500  -8.98100  1.000 44.51000  ? 44  ALA A N    1 
ATOM   615  C CA   . ALA A 1 44  ? 18.25800 -5.60900  -9.39300  1.000 50.83000  ? 44  ALA A CA   1 
ATOM   616  C C    . ALA A 1 44  ? 19.13200 -5.98300  -10.57300 1.000 40.33000  ? 44  ALA A C    1 
ATOM   617  O O    . ALA A 1 44  ? 19.44000 -5.13500  -11.42300 1.000 52.57000  ? 44  ALA A O    1 
ATOM   618  C CB   . ALA A 1 44  ? 19.12400 -5.08300  -8.22900  1.000 45.33000  ? 44  ALA A CB   1 
ATOM   619  H H    . ALA A 1 44  ? 17.64400 -7.07700  -8.20700  1.000 53.28000  ? 44  ALA A H    1 
ATOM   620  H HA   . ALA A 1 44  ? 17.66500 -4.88500  -9.64600  1.000 60.88000  ? 44  ALA A HA   1 
ATOM   621  H HB1  . ALA A 1 44  ? 19.62900 -4.31300  -8.53500  1.000 54.27000  ? 44  ALA A HB1  1 
ATOM   622  H HB2  . ALA A 1 44  ? 18.54500 -4.82900  -7.49400  1.000 54.27000  ? 44  ALA A HB2  1 
ATOM   623  H HB3  . ALA A 1 44  ? 19.73100 -5.78400  -7.94500  1.000 54.27000  ? 44  ALA A HB3  1 
ATOM   624  N N    . LEU A 1 45  ? 19.55900 -7.23900  -10.63000 1.000 49.01000  ? 45  LEU A N    1 
ATOM   625  C CA   . LEU A 1 45  ? 20.31000 -7.68800  -11.78200 1.000 51.02000  ? 45  LEU A CA   1 
ATOM   626  C C    . LEU A 1 45  ? 19.42200 -7.77300  -13.02200 1.000 55.76000  ? 45  LEU A C    1 
ATOM   627  O O    . LEU A 1 45  ? 19.86000 -7.42400  -14.12600 1.000 46.25000  ? 45  LEU A O    1 
ATOM   628  C CB   . LEU A 1 45  ? 20.95800 -9.01800  -11.44600 1.000 37.10000  ? 45  LEU A CB   1 
ATOM   629  C CG   . LEU A 1 45  ? 22.14500 -8.96500  -10.50100 1.000 44.72000  ? 45  LEU A CG   1 
ATOM   630  C CD1  . LEU A 1 45  ? 22.28600 -10.26800 -9.78400  1.000 46.46000  ? 45  LEU A CD1  1 
ATOM   631  C CD2  . LEU A 1 45  ? 23.40900 -8.61500  -11.21800 1.000 52.36000  ? 45  LEU A CD2  1 
ATOM   632  H H    . LEU A 1 45  ? 19.42900 -7.83600  -10.02400 1.000 58.69000  ? 45  LEU A H    1 
ATOM   633  H HA   . LEU A 1 45  ? 21.01400 -7.05600  -11.99400 1.000 61.10000  ? 45  LEU A HA   1 
ATOM   634  H HB2  . LEU A 1 45  ? 20.28800 -9.58500  -11.03200 1.000 44.40000  ? 45  LEU A HB2  1 
ATOM   635  H HB3  . LEU A 1 45  ? 21.26800 -9.42000  -12.27200 1.000 44.40000  ? 45  LEU A HB3  1 
ATOM   636  H HG   . LEU A 1 45  ? 21.98800 -8.26500  -9.84800  1.000 53.54000  ? 45  LEU A HG   1 
ATOM   637  H HD11 . LEU A 1 45  ? 23.03000 -10.20800 -9.16400  1.000 55.62000  ? 45  LEU A HD11 1 
ATOM   638  H HD12 . LEU A 1 45  ? 21.46600 -10.45300 -9.29900  1.000 55.62000  ? 45  LEU A HD12 1 
ATOM   639  H HD13 . LEU A 1 45  ? 22.45200 -10.96900 -10.43300 1.000 55.62000  ? 45  LEU A HD13 1 
ATOM   640  H HD21 . LEU A 1 45  ? 24.13000 -8.54800  -10.57200 1.000 62.71000  ? 45  LEU A HD21 1 
ATOM   641  H HD22 . LEU A 1 45  ? 23.60700 -9.31000  -11.86500 1.000 62.71000  ? 45  LEU A HD22 1 
ATOM   642  H HD23 . LEU A 1 45  ? 23.29000 -7.76500  -11.67100 1.000 62.71000  ? 45  LEU A HD23 1 
ATOM   643  N N    . ASP A 1 46  ? 18.18200 -8.27700  -12.86100 1.000 53.87000  ? 46  ASP A N    1 
ATOM   644  C CA   . ASP A 1 46  ? 17.22000 -8.30800  -13.96800 1.000 47.22000  ? 46  ASP A CA   1 
ATOM   645  C C    . ASP A 1 46  ? 17.06900 -6.91400  -14.57200 1.000 53.36000  ? 46  ASP A C    1 
ATOM   646  O O    . ASP A 1 46  ? 17.04800 -6.76600  -15.80100 1.000 48.63000  ? 46  ASP A O    1 
ATOM   647  C CB   . ASP A 1 46  ? 15.83500 -8.80600  -13.50800 1.000 35.59000  ? 46  ASP A CB   1 
ATOM   648  C CG   . ASP A 1 46  ? 15.74500 -10.32600 -13.27300 1.000 55.38000  ? 46  ASP A CG   1 
ATOM   649  O OD1  . ASP A 1 46  ? 16.55800 -11.11100 -13.82000 1.000 54.63000  ? 46  ASP A OD1  1 
ATOM   650  O OD2  . ASP A 1 46  ? 14.84000 -10.74700 -12.50900 1.000 57.37000  ? 46  ASP A OD2  1 
ATOM   651  H H    . ASP A 1 46  ? 17.88000 -8.60300  -12.12400 1.000 64.53000  ? 46  ASP A H    1 
ATOM   652  H HA   . ASP A 1 46  ? 17.55000 -8.93300  -14.63200 1.000 56.54000  ? 46  ASP A HA   1 
ATOM   653  H HB2  . ASP A 1 46  ? 15.61100 -8.36800  -12.67200 1.000 42.58000  ? 46  ASP A HB2  1 
ATOM   654  H HB3  . ASP A 1 46  ? 15.18200 -8.57700  -14.18800 1.000 42.58000  ? 46  ASP A HB3  1 
ATOM   655  N N    . LYS A 1 47  ? 17.03500 -5.86400  -13.70800 1.000 61.34000  ? 47  LYS A N    1 
ATOM   656  C CA   . LYS A 1 47  ? 16.83700 -4.49400  -14.17300 1.000 52.88000  ? 47  LYS A CA   1 
ATOM   657  C C    . LYS A 1 47  ? 18.02000 -3.99900  -15.00200 1.000 56.05000  ? 47  LYS A C    1 
ATOM   658  O O    . LYS A 1 47  ? 17.83300 -3.31900  -16.01600 1.000 67.62000  ? 47  LYS A O    1 
ATOM   659  C CB   . LYS A 1 47  ? 16.59200 -3.56200  -12.98000 1.000 56.65000  ? 47  LYS A CB   1 
ATOM   660  C CG   . LYS A 1 47  ? 15.27200 -3.80400  -12.19400 1.000 64.11000  ? 47  LYS A CG   1 
ATOM   661  C CD   . LYS A 1 47  ? 15.23600 -3.04500  -10.82500 1.000 55.60000  ? 47  LYS A CD   1 
ATOM   662  C CE   . LYS A 1 47  ? 14.50600 -3.84400  -9.71500  1.000 61.44000  ? 47  LYS A CE   1 
ATOM   663  N NZ   . LYS A 1 47  ? 15.29500 -4.00400  -8.42200  1.000 41.68000  ? 47  LYS A NZ   1 
ATOM   664  H H    . LYS A 1 47  ? 17.12500 -5.93300  -12.85600 1.000 73.48000  ? 47  LYS A H    1 
ATOM   665  H HA   . LYS A 1 47  ? 16.05000 -4.47500  -14.73900 1.000 63.33000  ? 47  LYS A HA   1 
ATOM   666  H HB2  . LYS A 1 47  ? 17.32500 -3.67200  -12.35400 1.000 67.85000  ? 47  LYS A HB2  1 
ATOM   667  H HB3  . LYS A 1 47  ? 16.56900 -2.64900  -13.30700 1.000 67.85000  ? 47  LYS A HB3  1 
ATOM   668  H HG2  . LYS A 1 47  ? 14.52400 -3.49500  -12.72800 1.000 76.81000  ? 47  LYS A HG2  1 
ATOM   669  H HG3  . LYS A 1 47  ? 15.18100 -4.75300  -12.01300 1.000 76.81000  ? 47  LYS A HG3  1 
ATOM   670  H HD2  . LYS A 1 47  ? 16.14500 -2.88400  -10.52900 1.000 66.60000  ? 47  LYS A HD2  1 
ATOM   671  H HD3  . LYS A 1 47  ? 14.77100 -2.20200  -10.94300 1.000 66.60000  ? 47  LYS A HD3  1 
ATOM   672  H HE2  . LYS A 1 47  ? 13.68000 -3.38400  -9.49700  1.000 73.61000  ? 47  LYS A HE2  1 
ATOM   673  H HE3  . LYS A 1 47  ? 14.31200 -4.73300  -10.05100 1.000 73.61000  ? 47  LYS A HE3  1 
ATOM   674  H HZ1  . LYS A 1 47  ? 16.01900 -4.50000  -8.56800  1.000 49.90000  ? 47  LYS A HZ1  1 
ATOM   675  H HZ2  . LYS A 1 47  ? 15.54700 -3.20600  -8.11800  1.000 49.90000  ? 47  LYS A HZ2  1 
ATOM   676  H HZ3  . LYS A 1 47  ? 14.79100 -4.40200  -7.80600  1.000 49.90000  ? 47  LYS A HZ3  1 
ATOM   677  N N    . ILE A 1 48  ? 19.24900 -4.30200  -14.58700 1.000 60.52000  ? 48  ILE A N    1 
ATOM   678  C CA   . ILE A 1 48  ? 20.37400 -3.88700  -15.42500 1.000 61.17000  ? 48  ILE A CA   1 
ATOM   679  C C    . ILE A 1 48  ? 20.45700 -4.73400  -16.70000 1.000 55.29000  ? 48  ILE A C    1 
ATOM   680  O O    . ILE A 1 48  ? 20.84500 -4.24100  -17.75800 1.000 61.91000  ? 48  ILE A O    1 
ATOM   681  C CB   . ILE A 1 48  ? 21.71800 -3.95000  -14.67500 1.000 67.23000  ? 48  ILE A CB   1 
ATOM   682  C CG1  . ILE A 1 48  ? 22.74700 -3.13600  -15.47600 1.000 57.21000  ? 48  ILE A CG1  1 
ATOM   683  C CG2  . ILE A 1 48  ? 22.19200 -5.41600  -14.47500 1.000 42.48000  ? 48  ILE A CG2  1 
ATOM   684  C CD1  . ILE A 1 48  ? 22.39100 -1.63100  -15.60000 1.000 53.26000  ? 48  ILE A CD1  1 
ATOM   685  H H    . ILE A 1 48  ? 19.44900 -4.72400  -13.86500 1.000 72.50000  ? 48  ILE A H    1 
ATOM   686  H HA   . ILE A 1 48  ? 20.20500 -2.96100  -15.65900 1.000 73.28000  ? 48  ILE A HA   1 
ATOM   687  H HB   . ILE A 1 48  ? 21.61200 -3.57200  -13.78900 1.000 80.55000  ? 48  ILE A HB   1 
ATOM   688  H HG12 . ILE A 1 48  ? 23.60800 -3.20100  -15.03400 1.000 68.53000  ? 48  ILE A HG12 1 
ATOM   689  H HG13 . ILE A 1 48  ? 22.80500 -3.50200  -16.37200 1.000 68.53000  ? 48  ILE A HG13 1 
ATOM   690  H HG21 . ILE A 1 48  ? 22.89000 -5.43400  -13.80200 1.000 50.85000  ? 48  ILE A HG21 1 
ATOM   691  H HG22 . ILE A 1 48  ? 21.43900 -5.95500  -14.18500 1.000 50.85000  ? 48  ILE A HG22 1 
ATOM   692  H HG23 . ILE A 1 48  ? 22.53600 -5.75500  -15.31700 1.000 50.85000  ? 48  ILE A HG23 1 
ATOM   693  H HD11 . ILE A 1 48  ? 23.20600 -1.12400  -15.73600 1.000 63.78000  ? 48  ILE A HD11 1 
ATOM   694  H HD12 . ILE A 1 48  ? 21.79500 -1.50900  -16.35600 1.000 63.78000  ? 48  ILE A HD12 1 
ATOM   695  H HD13 . ILE A 1 48  ? 21.95400 -1.34100  -14.78400 1.000 63.78000  ? 48  ILE A HD13 1 
ATOM   696  N N    . ARG A 1 49  ? 20.12500 -6.01900  -16.61700 1.000 55.74000  ? 49  ARG A N    1 
ATOM   697  C CA   . ARG A 1 49  ? 20.14500 -6.86400  -17.79600 1.000 59.47000  ? 49  ARG A CA   1 
ATOM   698  C C    . ARG A 1 49  ? 19.12500 -6.39600  -18.82900 1.000 80.35000  ? 49  ARG A C    1 
ATOM   699  O O    . ARG A 1 49  ? 19.41600 -6.43800  -20.03400 1.000 75.15000  ? 49  ARG A O    1 
ATOM   700  C CB   . ARG A 1 49  ? 19.90200 -8.30300  -17.37000 1.000 47.28000  ? 49  ARG A CB   1 
ATOM   701  C CG   . ARG A 1 49  ? 20.38500 -9.33900  -18.30800 1.000 74.63000  ? 49  ARG A CG   1 
ATOM   702  C CD   . ARG A 1 49  ? 20.56700 -10.68700 -17.60800 1.000 82.29000  ? 49  ARG A CD   1 
ATOM   703  N NE   . ARG A 1 49  ? 19.31200 -11.26000 -17.13200 1.000 61.92000  ? 49  ARG A NE   1 
ATOM   704  C CZ   . ARG A 1 49  ? 18.36800 -11.75000 -17.91600 1.000 69.81000  ? 49  ARG A CZ   1 
ATOM   705  N NH1  . ARG A 1 49  ? 18.48700 -11.72600 -19.23000 1.000 97.60000  ? 49  ARG A NH1  1 
ATOM   706  N NH2  . ARG A 1 49  ? 17.27600 -12.26500 -17.36700 1.000 85.66000  ? 49  ARG A NH2  1 
ATOM   707  H H    . ARG A 1 49  ? 19.88700 -6.42000  -15.89400 1.000 66.76000  ? 49  ARG A H    1 
ATOM   708  H HA   . ARG A 1 49  ? 21.01400 -6.82100  -18.22500 1.000 71.24000  ? 49  ARG A HA   1 
ATOM   709  H HB2  . ARG A 1 49  ? 20.35100 -8.45000  -16.52300 1.000 56.61000  ? 49  ARG A HB2  1 
ATOM   710  H HB3  . ARG A 1 49  ? 18.94600 -8.43300  -17.26600 1.000 56.61000  ? 49  ARG A HB3  1 
ATOM   711  H HG2  . ARG A 1 49  ? 19.74000 -9.45100  -19.02400 1.000 89.43000  ? 49  ARG A HG2  1 
ATOM   712  H HG3  . ARG A 1 49  ? 21.24200 -9.06700  -18.67400 1.000 89.43000  ? 49  ARG A HG3  1 
ATOM   713  H HD2  . ARG A 1 49  ? 20.96300 -11.31500 -18.23300 1.000 98.62000  ? 49  ARG A HD2  1 
ATOM   714  H HD3  . ARG A 1 49  ? 21.15000 -10.56900 -16.84200 1.000 98.62000  ? 49  ARG A HD3  1 
ATOM   715  H HE   . ARG A 1 49  ? 19.17800 -11.28000 -16.28300 1.000 74.18000  ? 49  ARG A HE   1 
ATOM   716  H HH11 . ARG A 1 49  ? 19.18900 -11.38700 -19.59200 1.000 117.00000 ? 49  ARG A HH11 1 
ATOM   717  H HH12 . ARG A 1 49  ? 17.86100 -12.04900 -19.72400 1.000 117.00000 ? 49  ARG A HH12 1 
ATOM   718  H HH21 . ARG A 1 49  ? 17.18900 -12.27800 -16.51100 1.000 102.67000 ? 49  ARG A HH21 1 
ATOM   719  H HH22 . ARG A 1 49  ? 16.65400 -12.58700 -17.86700 1.000 102.67000 ? 49  ARG A HH22 1 
ATOM   720  N N    . TYR A 1 50  ? 17.94900 -5.89900  -18.38100 1.000 67.40000  ? 50  TYR A N    1 
ATOM   721  C CA   . TYR A 1 50  ? 16.94200 -5.40000  -19.32800 1.000 71.14000  ? 50  TYR A CA   1 
ATOM   722  C C    . TYR A 1 50  ? 17.47100 -4.19200  -20.10300 1.000 59.82000  ? 50  TYR A C    1 
ATOM   723  O O    . TYR A 1 50  ? 17.38000 -4.13400  -21.33300 1.000 79.40000  ? 50  TYR A O    1 
ATOM   724  C CB   . TYR A 1 50  ? 15.63800 -5.03400  -18.61100 1.000 61.26000  ? 50  TYR A CB   1 
ATOM   725  C CG   . TYR A 1 50  ? 14.56900 -4.51500  -19.55500 1.000 72.83000  ? 50  TYR A CG   1 
ATOM   726  C CD1  . TYR A 1 50  ? 13.77600 -5.39300  -20.28900 1.000 63.84000  ? 50  TYR A CD1  1 
ATOM   727  C CD2  . TYR A 1 50  ? 14.34900 -3.14000  -19.71800 1.000 78.24000  ? 50  TYR A CD2  1 
ATOM   728  C CE1  . TYR A 1 50  ? 12.79500 -4.92100  -21.16000 1.000 62.46000  ? 50  TYR A CE1  1 
ATOM   729  C CE2  . TYR A 1 50  ? 13.35400 -2.65600  -20.60200 1.000 81.24000  ? 50  TYR A CE2  1 
ATOM   730  C CZ   . TYR A 1 50  ? 12.57900 -3.56000  -21.31200 1.000 72.85000  ? 50  TYR A CZ   1 
ATOM   731  O OH   . TYR A 1 50  ? 11.59300 -3.11800  -22.17600 1.000 78.81000  ? 50  TYR A OH   1 
ATOM   732  H H    . TYR A 1 50  ? 17.72000 -5.84400  -17.55400 1.000 80.76000  ? 50  TYR A H    1 
ATOM   733  H HA   . TYR A 1 50  ? 16.74400 -6.11400  -19.95300 1.000 85.25000  ? 50  TYR A HA   1 
ATOM   734  H HB2  . TYR A 1 50  ? 15.28900 -5.82500  -18.17000 1.000 73.38000  ? 50  TYR A HB2  1 
ATOM   735  H HB3  . TYR A 1 50  ? 15.82100 -4.34300  -17.95700 1.000 73.38000  ? 50  TYR A HB3  1 
ATOM   736  H HD1  . TYR A 1 50  ? 13.90300 -6.31000  -20.19700 1.000 76.49000  ? 50  TYR A HD1  1 
ATOM   737  H HD2  . TYR A 1 50  ? 14.86600 -2.53400  -19.23800 1.000 93.76000  ? 50  TYR A HD2  1 
ATOM   738  H HE1  . TYR A 1 50  ? 12.28000 -5.52600  -21.64400 1.000 74.83000  ? 50  TYR A HE1  1 
ATOM   739  H HE2  . TYR A 1 50  ? 13.22100 -1.74100  -20.70500 1.000 97.37000  ? 50  TYR A HE2  1 
ATOM   740  H HH   . TYR A 1 50  ? 11.64600 -2.28500  -22.26900 1.000 94.45000  ? 50  TYR A HH   1 
ATOM   741  N N    . GLN A 1 51  ? 18.03800 -3.22700  -19.39300 1.000 54.05000  ? 51  GLN A N    1 
ATOM   742  C CA   . GLN A 1 51  ? 18.64200 -2.07700  -20.04300 1.000 55.29000  ? 51  GLN A CA   1 
ATOM   743  C C    . GLN A 1 51  ? 19.74200 -2.47700  -21.00500 1.000 63.67000  ? 51  GLN A C    1 
ATOM   744  O O    . GLN A 1 51  ? 19.89800 -1.86600  -22.06200 1.000 83.41000  ? 51  GLN A O    1 
ATOM   745  C CB   . GLN A 1 51  ? 19.18900 -1.15300  -18.98100 1.000 51.75000  ? 51  GLN A CB   1 
ATOM   746  C CG   . GLN A 1 51  ? 18.10500 -0.56600  -18.08000 1.000 66.64000  ? 51  GLN A CG   1 
ATOM   747  C CD   . GLN A 1 51  ? 18.61300 0.58900   -17.25800 1.000 74.88000  ? 51  GLN A CD   1 
ATOM   748  O OE1  . GLN A 1 51  ? 19.79200 0.80800   -17.24200 1.000 76.55000  ? 51  GLN A OE1  1 
ATOM   749  N NE2  . GLN A 1 51  ? 17.72500 1.33200   -16.57000 1.000 74.72000  ? 51  GLN A NE2  1 
ATOM   750  H H    . GLN A 1 51  ? 18.08700 -3.21400  -18.53400 1.000 64.74000  ? 51  GLN A H    1 
ATOM   751  H HA   . GLN A 1 51  ? 17.96400 -1.61400  -20.56000 1.000 66.23000  ? 51  GLN A HA   1 
ATOM   752  H HB2  . GLN A 1 51  ? 19.80700 -1.64900  -18.42100 1.000 61.98000  ? 51  GLN A HB2  1 
ATOM   753  H HB3  . GLN A 1 51  ? 19.64900 -0.41600  -19.41300 1.000 61.98000  ? 51  GLN A HB3  1 
ATOM   754  H HG2  . GLN A 1 51  ? 17.37300 -0.24700  -18.62900 1.000 79.84000  ? 51  GLN A HG2  1 
ATOM   755  H HG3  . GLN A 1 51  ? 17.79000 -1.25400  -17.47300 1.000 79.84000  ? 51  GLN A HG3  1 
ATOM   756  H HE21 . GLN A 1 51  ? 16.88700 1.14300   -16.60400 1.000 89.55000  ? 51  GLN A HE21 1 
ATOM   757  H HE22 . GLN A 1 51  ? 17.99600 1.99500   -16.09400 1.000 89.55000  ? 51  GLN A HE22 1 
ATOM   758  N N    . ALA A 1 52  ? 20.50500 -3.50300  -20.65500 1.000 70.81000  ? 52  ALA A N    1 
ATOM   759  C CA   . ALA A 1 52  ? 21.59300 -3.97000  -21.50000 1.000 88.02000  ? 52  ALA A CA   1 
ATOM   760  C C    . ALA A 1 52  ? 21.09500 -4.64700  -22.77000 1.000 87.01000  ? 52  ALA A C    1 
ATOM   761  O O    . ALA A 1 52  ? 21.84300 -4.73400  -23.74900 1.000 86.38000  ? 52  ALA A O    1 
ATOM   762  C CB   . ALA A 1 52  ? 22.47500 -4.94500  -20.71500 1.000 87.16000  ? 52  ALA A CB   1 
ATOM   763  H H    . ALA A 1 52  ? 20.41300 -3.95100  -19.92700 1.000 84.85000  ? 52  ALA A H    1 
ATOM   764  H HA   . ALA A 1 52  ? 22.12300 -3.20000  -21.76100 1.000 105.50000 ? 52  ALA A HA   1 
ATOM   765  H HB1  . ALA A 1 52  ? 23.20000 -5.24500  -21.28600 1.000 104.47000 ? 52  ALA A HB1  1 
ATOM   766  H HB2  . ALA A 1 52  ? 22.83400 -4.49000  -19.93700 1.000 104.47000 ? 52  ALA A HB2  1 
ATOM   767  H HB3  . ALA A 1 52  ? 21.93800 -5.70300  -20.43700 1.000 104.47000 ? 52  ALA A HB3  1 
ATOM   768  N N    . LEU A 1 53  ? 19.86900 -5.17500  -22.76400 1.000 80.69000  ? 53  LEU A N    1 
ATOM   769  C CA   . LEU A 1 53  ? 19.27400 -5.63200  -24.01400 1.000 82.74000  ? 53  LEU A CA   1 
ATOM   770  C C    . LEU A 1 53  ? 19.25500 -4.50500  -25.03400 1.000 91.63000  ? 53  LEU A C    1 
ATOM   771  O O    . LEU A 1 53  ? 19.61500 -4.70400  -26.19700 1.000 112.58000 ? 53  LEU A O    1 
ATOM   772  C CB   . LEU A 1 53  ? 17.85900 -6.15900  -23.77600 1.000 70.56000  ? 53  LEU A CB   1 
ATOM   773  C CG   . LEU A 1 53  ? 17.78100 -7.47700  -23.00100 1.000 97.70000  ? 53  LEU A CG   1 
ATOM   774  C CD1  . LEU A 1 53  ? 16.51500 -8.25700  -23.43200 1.000 91.32000  ? 53  LEU A CD1  1 
ATOM   775  C CD2  . LEU A 1 53  ? 19.05700 -8.35300  -23.11300 1.000 91.22000  ? 53  LEU A CD2  1 
ATOM   776  H H    . LEU A 1 53  ? 19.37600 -5.27700  -22.06700 1.000 96.71000  ? 53  LEU A H    1 
ATOM   777  H HA   . LEU A 1 53  ? 19.80200 -6.36700  -24.36400 1.000 99.16000  ? 53  LEU A HA   1 
ATOM   778  H HB2  . LEU A 1 53  ? 17.36600 -5.49400  -23.27000 1.000 84.55000  ? 53  LEU A HB2  1 
ATOM   779  H HB3  . LEU A 1 53  ? 17.43600 -6.30100  -24.63700 1.000 84.55000  ? 53  LEU A HB3  1 
ATOM   780  H HG   . LEU A 1 53  ? 17.71900 -7.26100  -22.05800 1.000 117.11000 ? 53  LEU A HG   1 
ATOM   781  H HD11 . LEU A 1 53  ? 16.43300 -9.05400  -22.88600 1.000 109.46000 ? 53  LEU A HD11 1 
ATOM   782  H HD12 . LEU A 1 53  ? 15.73700 -7.69000  -23.30800 1.000 109.46000 ? 53  LEU A HD12 1 
ATOM   783  H HD13 . LEU A 1 53  ? 16.59800 -8.50300  -24.36700 1.000 109.46000 ? 53  LEU A HD13 1 
ATOM   784  H HD21 . LEU A 1 53  ? 18.90100 -9.19800  -22.66300 1.000 109.34000 ? 53  LEU A HD21 1 
ATOM   785  H HD22 . LEU A 1 53  ? 19.25200 -8.50800  -24.05000 1.000 109.34000 ? 53  LEU A HD22 1 
ATOM   786  H HD23 . LEU A 1 53  ? 19.79700 -7.88700  -22.69300 1.000 109.34000 ? 53  LEU A HD23 1 
ATOM   787  N N    . SER A 1 54  ? 18.85300 -3.30900  -24.61000 1.000 85.62000  ? 54  SER A N    1 
ATOM   788  C CA   . SER A 1 54  ? 18.89800 -2.14500  -25.48300 1.000 64.88000  ? 54  SER A CA   1 
ATOM   789  C C    . SER A 1 54  ? 20.33300 -1.65500  -25.65900 1.000 92.68000  ? 54  SER A C    1 
ATOM   790  O O    . SER A 1 54  ? 20.86000 -1.62300  -26.78000 1.000 107.16000 ? 54  SER A O    1 
ATOM   791  C CB   . SER A 1 54  ? 17.98700 -1.04500  -24.91600 1.000 54.71000  ? 54  SER A CB   1 
ATOM   792  O OG   . SER A 1 54  ? 16.63300 -1.44700  -24.83700 1.000 94.89000  ? 54  SER A OG   1 
ATOM   793  H H    . SER A 1 54  ? 18.55100 -3.14600  -23.82100 1.000 102.62000 ? 54  SER A H    1 
ATOM   794  H HA   . SER A 1 54  ? 18.56300 -2.38200  -26.36200 1.000 77.73000  ? 54  SER A HA   1 
ATOM   795  H HB2  . SER A 1 54  ? 18.29500 -0.81900  -24.02500 1.000 65.53000  ? 54  SER A HB2  1 
ATOM   796  H HB3  . SER A 1 54  ? 18.04500 -0.26800  -25.49400 1.000 65.53000  ? 54  SER A HB3  1 
ATOM   797  H HG   . SER A 1 54  ? 16.14800 -0.78700  -24.65000 1.000 113.75000 ? 54  SER A HG   1 
ATOM   798  N N    . ASP A 1 55  ? 21.00600 -1.33100  -24.54300 1.000 97.54000  ? 55  ASP A N    1 
ATOM   799  C CA   . ASP A 1 55  ? 22.25900 -0.57000  -24.48700 1.000 81.32000  ? 55  ASP A CA   1 
ATOM   800  C C    . ASP A 1 55  ? 23.28900 -1.40700  -23.73500 1.000 80.29000  ? 55  ASP A C    1 
ATOM   801  O O    . ASP A 1 55  ? 23.41200 -1.31000  -22.50200 1.000 92.38000  ? 55  ASP A O    1 
ATOM   802  C CB   . ASP A 1 55  ? 21.98100 0.78700   -23.82600 1.000 63.62000  ? 55  ASP A CB   1 
ATOM   803  C CG   . ASP A 1 55  ? 23.21700 1.66400   -23.63000 1.000 73.77000  ? 55  ASP A CG   1 
ATOM   804  O OD1  . ASP A 1 55  ? 24.31300 1.29800   -24.10800 1.000 74.71000  ? 55  ASP A OD1  1 
ATOM   805  O OD2  . ASP A 1 55  ? 23.06800 2.72400   -22.95600 1.000 73.96000  ? 55  ASP A OD2  1 
ATOM   806  H H    . ASP A 1 55  ? 20.73700 -1.55700  -23.75800 1.000 116.93000 ? 55  ASP A H    1 
ATOM   807  H HA   . ASP A 1 55  ? 22.62800 -0.41200  -25.37100 1.000 97.46000  ? 55  ASP A HA   1 
ATOM   808  H HB2  . ASP A 1 55  ? 21.35800 1.28000   -24.38200 1.000 76.23000  ? 55  ASP A HB2  1 
ATOM   809  H HB3  . ASP A 1 55  ? 21.59300 0.63000   -22.95100 1.000 76.23000  ? 55  ASP A HB3  1 
ATOM   810  N N    . PRO A 1 56  ? 24.06600 -2.24400  -24.44100 1.000 75.00000  ? 56  PRO A N    1 
ATOM   811  C CA   . PRO A 1 56  ? 25.04800 -3.10100  -23.73800 1.000 77.12000  ? 56  PRO A CA   1 
ATOM   812  C C    . PRO A 1 56  ? 26.25000 -2.35400  -23.12500 1.000 77.99000  ? 56  PRO A C    1 
ATOM   813  O O    . PRO A 1 56  ? 27.08200 -2.99200  -22.45100 1.000 63.19000  ? 56  PRO A O    1 
ATOM   814  C CB   . PRO A 1 56  ? 25.52100 -4.07500  -24.83400 1.000 70.64000  ? 56  PRO A CB   1 
ATOM   815  C CG   . PRO A 1 56  ? 24.43800 -4.03600  -25.94000 1.000 64.00000  ? 56  PRO A CG   1 
ATOM   816  C CD   . PRO A 1 56  ? 23.92500 -2.60100  -25.87800 1.000 75.96000  ? 56  PRO A CD   1 
ATOM   817  H HA   . PRO A 1 56  ? 24.59000 -3.58900  -23.03600 1.000 92.43000  ? 56  PRO A HA   1 
ATOM   818  H HB2  . PRO A 1 56  ? 26.37800 -3.78200  -25.18200 1.000 84.64000  ? 56  PRO A HB2  1 
ATOM   819  H HB3  . PRO A 1 56  ? 25.60100 -4.96800  -24.46400 1.000 84.64000  ? 56  PRO A HB3  1 
ATOM   820  H HG2  . PRO A 1 56  ? 24.83100 -4.23300  -26.80400 1.000 76.68000  ? 56  PRO A HG2  1 
ATOM   821  H HG3  . PRO A 1 56  ? 23.73200 -4.67100  -25.74300 1.000 76.68000  ? 56  PRO A HG3  1 
ATOM   822  H HD2  . PRO A 1 56  ? 24.46600 -2.01800  -26.43300 1.000 91.02000  ? 56  PRO A HD2  1 
ATOM   823  H HD3  . PRO A 1 56  ? 22.99700 -2.55500  -26.15500 1.000 91.02000  ? 56  PRO A HD3  1 
ATOM   824  N N    . SER A 1 57  ? 26.38700 -1.05100  -23.36500 1.000 78.98000  ? 57  SER A N    1 
ATOM   825  C CA   . SER A 1 57  ? 27.36300 -0.23900  -22.65900 1.000 86.42000  ? 57  SER A CA   1 
ATOM   826  C C    . SER A 1 57  ? 26.99900 -0.02800  -21.19600 1.000 88.11000  ? 57  SER A C    1 
ATOM   827  O O    . SER A 1 57  ? 27.84500 0.43900   -20.41800 1.000 92.71000  ? 57  SER A O    1 
ATOM   828  C CB   . SER A 1 57  ? 27.47700 1.09500   -23.38200 1.000 61.80000  ? 57  SER A CB   1 
ATOM   829  O OG   . SER A 1 57  ? 26.64800 2.09000   -22.78700 1.000 81.84000  ? 57  SER A OG   1 
ATOM   830  H H    . SER A 1 57  ? 25.92000 -0.61300  -23.93800 1.000 94.66000  ? 57  SER A H    1 
ATOM   831  H HA   . SER A 1 57  ? 28.23100 -0.67200  -22.66700 1.000 103.58000 ? 57  SER A HA   1 
ATOM   832  H HB2  . SER A 1 57  ? 28.40000 1.39300   -23.34400 1.000 74.04000  ? 57  SER A HB2  1 
ATOM   833  H HB3  . SER A 1 57  ? 27.20600 0.97400   -24.30600 1.000 74.04000  ? 57  SER A HB3  1 
ATOM   834  H HG   . SER A 1 57  ? 25.84500 1.84200   -22.80300 1.000 98.08000  ? 57  SER A HG   1 
ATOM   835  N N    . GLN A 1 58  ? 25.76600 -0.35100  -20.80500 1.000 77.52000  ? 58  GLN A N    1 
ATOM   836  C CA   . GLN A 1 58  ? 25.36500 -0.14700  -19.42000 1.000 91.18000  ? 58  GLN A CA   1 
ATOM   837  C C    . GLN A 1 58  ? 26.10100 -1.10200  -18.50400 1.000 84.77000  ? 58  GLN A C    1 
ATOM   838  O O    . GLN A 1 58  ? 26.36200 -0.76500  -17.33800 1.000 69.67000  ? 58  GLN A O    1 
ATOM   839  C CB   . GLN A 1 58  ? 23.86400 -0.33200  -19.27900 1.000 80.30000  ? 58  GLN A CB   1 
ATOM   840  C CG   . GLN A 1 58  ? 23.07400 0.94800   -19.49600 1.000 66.15000  ? 58  GLN A CG   1 
ATOM   841  C CD   . GLN A 1 58  ? 23.41700 2.02100   -18.50600 1.000 85.78000  ? 58  GLN A CD   1 
ATOM   842  O OE1  . GLN A 1 58  ? 23.15000 1.88600   -17.30400 1.000 92.15000  ? 58  GLN A OE1  1 
ATOM   843  N NE2  . GLN A 1 58  ? 24.04800 3.08300   -18.98300 1.000 99.22000  ? 58  GLN A NE2  1 
ATOM   844  H H    . GLN A 1 58  ? 25.15700 -0.68400  -21.31300 1.000 92.90000  ? 58  GLN A H    1 
ATOM   845  H HA   . GLN A 1 58  ? 25.57700 0.76200   -19.15500 1.000 109.29000 ? 58  GLN A HA   1 
ATOM   846  H HB2  . GLN A 1 58  ? 23.56500 -0.98100  -19.93500 1.000 96.24000  ? 58  GLN A HB2  1 
ATOM   847  H HB3  . GLN A 1 58  ? 23.67000 -0.65300  -18.38400 1.000 96.24000  ? 58  GLN A HB3  1 
ATOM   848  H HG2  . GLN A 1 58  ? 23.26400 1.28900   -20.38400 1.000 79.26000  ? 58  GLN A HG2  1 
ATOM   849  H HG3  . GLN A 1 58  ? 22.12800 0.75400   -19.41100 1.000 79.26000  ? 58  GLN A HG3  1 
ATOM   850  H HE21 . GLN A 1 58  ? 24.23900 3.13000   -19.82000 1.000 118.94000 ? 58  GLN A HE21 1 
ATOM   851  H HE22 . GLN A 1 58  ? 24.26600 3.72700   -18.45600 1.000 118.94000 ? 58  GLN A HE22 1 
ATOM   852  N N    . LEU A 1 59  ? 26.46900 -2.27400  -19.03900 1.000 60.08000  ? 59  LEU A N    1 
ATOM   853  C CA   . LEU A 1 59  ? 27.19100 -3.28600  -18.29500 1.000 79.43000  ? 59  LEU A CA   1 
ATOM   854  C C    . LEU A 1 59  ? 28.66800 -3.00400  -18.12600 1.000 62.41000  ? 59  LEU A C    1 
ATOM   855  O O    . LEU A 1 59  ? 29.31100 -3.76100  -17.39400 1.000 75.57000  ? 59  LEU A O    1 
ATOM   856  C CB   . LEU A 1 59  ? 27.08600 -4.63700  -18.97200 1.000 53.93000  ? 59  LEU A CB   1 
ATOM   857  C CG   . LEU A 1 59  ? 25.67700 -5.23900  -18.90500 1.000 63.30000  ? 59  LEU A CG   1 
ATOM   858  C CD1  . LEU A 1 59  ? 25.64700 -6.55300  -19.68800 1.000 58.32000  ? 59  LEU A CD1  1 
ATOM   859  C CD2  . LEU A 1 59  ? 25.22600 -5.47300  -17.47200 1.000 81.16000  ? 59  LEU A CD2  1 
ATOM   860  H H    . LEU A 1 59  ? 26.30300 -2.50400  -19.85100 1.000 71.97000  ? 59  LEU A H    1 
ATOM   861  H HA   . LEU A 1 59  ? 26.77100 -3.31700  -17.42100 1.000 95.19000  ? 59  LEU A HA   1 
ATOM   862  H HB2  . LEU A 1 59  ? 27.32500 -4.53800  -19.90700 1.000 64.59000  ? 59  LEU A HB2  1 
ATOM   863  H HB3  . LEU A 1 59  ? 27.69500 -5.25400  -18.53700 1.000 64.59000  ? 59  LEU A HB3  1 
ATOM   864  H HG   . LEU A 1 59  ? 25.05400 -4.60900  -19.30000 1.000 75.84000  ? 59  LEU A HG   1 
ATOM   865  H HD11 . LEU A 1 59  ? 24.75500 -6.93000  -19.63600 1.000 69.86000  ? 59  LEU A HD11 1 
ATOM   866  H HD12 . LEU A 1 59  ? 25.87600 -6.37400  -20.61400 1.000 69.86000  ? 59  LEU A HD12 1 
ATOM   867  H HD13 . LEU A 1 59  ? 26.28900 -7.16700  -19.30000 1.000 69.86000  ? 59  LEU A HD13 1 
ATOM   868  H HD21 . LEU A 1 59  ? 24.32700 -5.83900  -17.48000 1.000 97.27000  ? 59  LEU A HD21 1 
ATOM   869  H HD22 . LEU A 1 59  ? 25.83400 -6.09800  -17.04800 1.000 97.27000  ? 59  LEU A HD22 1 
ATOM   870  H HD23 . LEU A 1 59  ? 25.23400 -4.62800  -16.99600 1.000 97.27000  ? 59  LEU A HD23 1 
ATOM   871  N N    . GLU A 1 60  ? 29.22200 -1.95900  -18.75300 1.000 77.41000  ? 60  GLU A N    1 
ATOM   872  C CA   . GLU A 1 60  ? 30.68600 -1.82800  -18.78300 1.000 86.39000  ? 60  GLU A CA   1 
ATOM   873  C C    . GLU A 1 60  ? 31.26700 -1.40400  -17.42800 1.000 81.89000  ? 60  GLU A C    1 
ATOM   874  O O    . GLU A 1 60  ? 32.46200 -1.62600  -17.19600 1.000 67.98000  ? 60  GLU A O    1 
ATOM   875  C CB   . GLU A 1 60  ? 31.12300 -0.86000  -19.90500 1.000 74.84000  ? 60  GLU A CB   1 
ATOM   876  C CG   . GLU A 1 60  ? 31.02800 -1.50100  -21.27400 1.000 64.99000  ? 60  GLU A CG   1 
ATOM   877  C CD   . GLU A 1 60  ? 31.23500 -0.57200  -22.49300 1.000 81.71000  ? 60  GLU A CD   1 
ATOM   878  O OE1  . GLU A 1 60  ? 31.46400 0.65300   -22.34100 1.000 74.39000  ? 60  GLU A OE1  1 
ATOM   879  O OE2  . GLU A 1 60  ? 31.11100 -1.10500  -23.62400 1.000 73.19000  ? 60  GLU A OE2  1 
ATOM   880  H H    . GLU A 1 60  ? 28.79000 -1.33300  -19.15500 1.000 92.77000  ? 60  GLU A H    1 
ATOM   881  H HA   . GLU A 1 60  ? 31.06900 -2.69300  -18.99700 1.000 103.54000 ? 60  GLU A HA   1 
ATOM   882  H HB2  . GLU A 1 60  ? 30.54700 -0.07900  -19.89500 1.000 89.69000  ? 60  GLU A HB2  1 
ATOM   883  H HB3  . GLU A 1 60  ? 32.04400 -0.59500  -19.75700 1.000 89.69000  ? 60  GLU A HB3  1 
ATOM   884  H HG2  . GLU A 1 60  ? 31.70400 -2.19400  -21.32900 1.000 77.86000  ? 60  GLU A HG2  1 
ATOM   885  H HG3  . GLU A 1 60  ? 30.14500 -1.89100  -21.36300 1.000 77.86000  ? 60  GLU A HG3  1 
ATOM   886  N N    . SER A 1 61  ? 30.44800 -0.84000  -16.52100 1.000 74.82000  ? 61  SER A N    1 
ATOM   887  C CA   . SER A 1 61  ? 30.92600 -0.42900  -15.19700 1.000 71.15000  ? 61  SER A CA   1 
ATOM   888  C C    . SER A 1 61  ? 31.24700 -1.62600  -14.29200 1.000 66.57000  ? 61  SER A C    1 
ATOM   889  O O    . SER A 1 61  ? 31.96400 -1.47100  -13.29500 1.000 58.97000  ? 61  SER A O    1 
ATOM   890  C CB   . SER A 1 61  ? 29.88300 0.47300   -14.50900 1.000 62.20000  ? 61  SER A CB   1 
ATOM   891  O OG   . SER A 1 61  ? 28.57300 -0.08500  -14.65800 1.000 69.68000  ? 61  SER A OG   1 
ATOM   892  H H    . SER A 1 61  ? 29.61300 -0.68500  -16.65100 1.000 89.66000  ? 61  SER A H    1 
ATOM   893  H HA   . SER A 1 61  ? 31.74000 0.08500   -15.31300 1.000 85.26000  ? 61  SER A HA   1 
ATOM   894  H HB2  . SER A 1 61  ? 30.09400 0.54200   -13.56500 1.000 74.52000  ? 61  SER A HB2  1 
ATOM   895  H HB3  . SER A 1 61  ? 29.90300 1.35200   -14.91800 1.000 74.52000  ? 61  SER A HB3  1 
ATOM   896  H HG   . SER A 1 61  ? 28.00900 0.39400   -14.26100 1.000 83.50000  ? 61  SER A HG   1 
ATOM   897  N N    . GLU A 1 62  ? 30.73600 -2.79500  -14.61100 1.000 43.74000  ? 62  GLU A N    1 
ATOM   898  C CA   . GLU A 1 62  ? 30.97000 -4.03700  -13.88800 1.000 47.11000  ? 62  GLU A CA   1 
ATOM   899  C C    . GLU A 1 62  ? 30.42100 -5.19700  -14.72300 1.000 58.59000  ? 62  GLU A C    1 
ATOM   900  O O    . GLU A 1 62  ? 29.27900 -5.65500  -14.54900 1.000 61.41000  ? 62  GLU A O    1 
ATOM   901  C CB   . GLU A 1 62  ? 30.32800 -3.98400  -12.49800 1.000 60.58000  ? 62  GLU A CB   1 
ATOM   902  C CG   . GLU A 1 62  ? 30.35200 -5.31600  -11.74100 1.000 68.01000  ? 62  GLU A CG   1 
ATOM   903  C CD   . GLU A 1 62  ? 31.74700 -5.79800  -11.36000 1.000 71.84000  ? 62  GLU A CD   1 
ATOM   904  O OE1  . GLU A 1 62  ? 32.28600 -5.31500  -10.34600 1.000 70.87000  ? 62  GLU A OE1  1 
ATOM   905  O OE2  . GLU A 1 62  ? 32.27500 -6.68400  -12.06200 1.000 76.92000  ? 62  GLU A OE2  1 
ATOM   906  H H    . GLU A 1 62  ? 30.21500 -2.90900  -15.28600 1.000 52.36000  ? 62  GLU A H    1 
ATOM   907  H HA   . GLU A 1 62  ? 31.92000 -4.18000  -13.75100 1.000 56.41000  ? 62  GLU A HA   1 
ATOM   908  H HB2  . GLU A 1 62  ? 30.80600 -3.33200  -11.96100 1.000 72.57000  ? 62  GLU A HB2  1 
ATOM   909  H HB3  . GLU A 1 62  ? 29.40100 -3.71800  -12.59500 1.000 72.57000  ? 62  GLU A HB3  1 
ATOM   910  H HG2  . GLU A 1 62  ? 29.84300 -5.21600  -10.92100 1.000 81.49000  ? 62  GLU A HG2  1 
ATOM   911  H HG3  . GLU A 1 62  ? 29.94900 -5.99800  -12.30000 1.000 81.49000  ? 62  GLU A HG3  1 
ATOM   912  N N    . PRO A 1 63  ? 31.21000 -5.67300  -15.66100 1.000 54.46000  ? 63  PRO A N    1 
ATOM   913  C CA   . PRO A 1 63  ? 30.69900 -6.63300  -16.63600 1.000 55.58000  ? 63  PRO A CA   1 
ATOM   914  C C    . PRO A 1 63  ? 30.14600 -7.90300  -16.04100 1.000 59.90000  ? 63  PRO A C    1 
ATOM   915  O O    . PRO A 1 63  ? 29.28200 -8.54400  -16.66500 1.000 56.06000  ? 63  PRO A O    1 
ATOM   916  C CB   . PRO A 1 63  ? 31.94100 -6.91700  -17.49000 1.000 51.38000  ? 63  PRO A CB   1 
ATOM   917  C CG   . PRO A 1 63  ? 32.63500 -5.65600  -17.47200 1.000 53.15000  ? 63  PRO A CG   1 
ATOM   918  C CD   . PRO A 1 63  ? 32.49600 -5.10200  -16.07400 1.000 55.57000  ? 63  PRO A CD   1 
ATOM   919  H HA   . PRO A 1 63  ? 30.00200 -6.21600  -17.16700 1.000 66.57000  ? 63  PRO A HA   1 
ATOM   920  H HB2  . PRO A 1 63  ? 32.47500 -7.62100  -17.09000 1.000 61.53000  ? 63  PRO A HB2  1 
ATOM   921  H HB3  . PRO A 1 63  ? 31.68400 -7.16800  -18.39100 1.000 61.53000  ? 63  PRO A HB3  1 
ATOM   922  H HG2  . PRO A 1 63  ? 33.57000 -5.79800  -17.69000 1.000 63.66000  ? 63  PRO A HG2  1 
ATOM   923  H HG3  . PRO A 1 63  ? 32.23100 -5.05600  -18.11800 1.000 63.66000  ? 63  PRO A HG3  1 
ATOM   924  H HD2  . PRO A 1 63  ? 33.21700 -5.40600  -15.50100 1.000 66.56000  ? 63  PRO A HD2  1 
ATOM   925  H HD3  . PRO A 1 63  ? 32.46400 -4.13200  -16.08100 1.000 66.56000  ? 63  PRO A HD3  1 
ATOM   926  N N    . GLU A 1 64  ? 30.68800 -8.34800  -14.92100 1.000 63.16000  ? 64  GLU A N    1 
ATOM   927  C CA   . GLU A 1 64  ? 30.25200 -9.62600  -14.32100 1.000 61.74000  ? 64  GLU A CA   1 
ATOM   928  C C    . GLU A 1 64  ? 28.92400 -9.39500  -13.60900 1.000 52.08000  ? 64  GLU A C    1 
ATOM   929  O O    . GLU A 1 64  ? 28.81800 -8.39400  -12.91300 1.000 57.82000  ? 64  GLU A O    1 
ATOM   930  C CB   . GLU A 1 64  ? 31.36400 -10.15200 -13.42400 1.000 80.27000  ? 64  GLU A CB   1 
ATOM   931  C CG   . GLU A 1 64  ? 32.33500 -11.06500 -14.16000 1.000 80.92000  ? 64  GLU A CG   1 
ATOM   932  C CD   . GLU A 1 64  ? 31.76800 -12.43700 -14.45900 1.000 115.30000 ? 64  GLU A CD   1 
ATOM   933  O OE1  . GLU A 1 64  ? 31.31100 -13.11000 -13.51200 1.000 92.22000  ? 64  GLU A OE1  1 
ATOM   934  O OE2  . GLU A 1 64  ? 31.78100 -12.82600 -15.64400 1.000 101.82000 ? 64  GLU A OE2  1 
ATOM   935  H H    . GLU A 1 64  ? 31.33700 -7.90100  -14.48100 1.000 75.66000  ? 64  GLU A H    1 
ATOM   936  H HA   . GLU A 1 64  ? 30.11000 -10.28000 -15.04700 1.000 73.97000  ? 64  GLU A HA   1 
ATOM   937  H HB2  . GLU A 1 64  ? 31.86000 -9.39100  -13.05700 1.000 96.20000  ? 64  GLU A HB2  1 
ATOM   938  H HB3  . GLU A 1 64  ? 30.95900 -10.63200 -12.67300 1.000 96.20000  ? 64  GLU A HB3  1 
ATOM   939  H HG2  . GLU A 1 64  ? 32.59100 -10.64200 -15.00700 1.000 96.99000  ? 64  GLU A HG2  1 
ATOM   940  H HG3  . GLU A 1 64  ? 33.14600 -11.17200 -13.62100 1.000 96.99000  ? 64  GLU A HG3  1 
ATOM   941  N N    . LEU A 1 65  ? 27.95300 -10.26300 -13.85200 1.000 50.23000  ? 65  LEU A N    1 
ATOM   942  C CA   . LEU A 1 65  ? 26.61600 -10.16500 -13.23400 1.000 51.08000  ? 65  LEU A CA   1 
ATOM   943  C C    . LEU A 1 65  ? 26.56000 -11.24300 -12.15900 1.000 53.69000  ? 65  LEU A C    1 
ATOM   944  O O    . LEU A 1 65  ? 26.59200 -12.41500 -12.51600 1.000 47.76000  ? 65  LEU A O    1 
ATOM   945  C CB   . LEU A 1 65  ? 25.52700 -10.27500 -14.29800 1.000 52.57000  ? 65  LEU A CB   1 
ATOM   946  C CG   . LEU A 1 65  ? 25.33900 -9.05500  -15.20000 1.000 49.51000  ? 65  LEU A CG   1 
ATOM   947  C CD1  . LEU A 1 65  ? 24.14200 -9.27900  -16.08700 1.000 62.56000  ? 65  LEU A CD1  1 
ATOM   948  C CD2  . LEU A 1 65  ? 25.17300 -7.76900  -14.42700 1.000 55.08000  ? 65  LEU A CD2  1 
ATOM   949  H H    . LEU A 1 65  ? 28.07400 -10.95700 -14.41500 1.000 60.15000  ? 65  LEU A H    1 
ATOM   950  H HA   . LEU A 1 65  ? 26.53600 -9.30200  -12.80100 1.000 61.17000  ? 65  LEU A HA   1 
ATOM   951  H HB2  . LEU A 1 65  ? 25.73300 -11.05200 -14.86700 1.000 62.96000  ? 65  LEU A HB2  1 
ATOM   952  H HB3  . LEU A 1 65  ? 24.67300 -10.45400 -13.84100 1.000 62.96000  ? 65  LEU A HB3  1 
ATOM   953  H HG   . LEU A 1 65  ? 26.14100 -8.96700  -15.77600 1.000 59.29000  ? 65  LEU A HG   1 
ATOM   954  H HD11 . LEU A 1 65  ? 24.05000 -8.53200  -16.70400 1.000 74.95000  ? 65  LEU A HD11 1 
ATOM   955  H HD12 . LEU A 1 65  ? 24.25900 -10.10200 -16.59000 1.000 74.95000  ? 65  LEU A HD12 1 
ATOM   956  H HD13 . LEU A 1 65  ? 23.34100 -9.34600  -15.53900 1.000 74.95000  ? 65  LEU A HD13 1 
ATOM   957  H HD21 . LEU A 1 65  ? 24.82800 -7.07700  -15.01500 1.000 65.97000  ? 65  LEU A HD21 1 
ATOM   958  H HD22 . LEU A 1 65  ? 24.55200 -7.90800  -13.69400 1.000 65.97000  ? 65  LEU A HD22 1 
ATOM   959  H HD23 . LEU A 1 65  ? 26.03400 -7.49000  -14.07100 1.000 65.97000  ? 65  LEU A HD23 1 
ATOM   960  N N    . PHE A 1 66  ? 26.51000 -10.84100 -10.89600 1.000 40.61000  ? 66  PHE A N    1 
ATOM   961  C CA   . PHE A 1 66  ? 26.59600 -11.81100 -9.78700  1.000 55.81000  ? 66  PHE A CA   1 
ATOM   962  C C    . PHE A 1 66  ? 25.96500 -11.36300 -8.50000  1.000 46.19000  ? 66  PHE A C    1 
ATOM   963  O O    . PHE A 1 66  ? 25.72500 -10.18900 -8.32700  1.000 34.86000  ? 66  PHE A O    1 
ATOM   964  C CB   . PHE A 1 66  ? 28.08200 -12.02300 -9.47900  1.000 39.11000  ? 66  PHE A CB   1 
ATOM   965  C CG   . PHE A 1 66  ? 28.81500 -10.80100 -8.95200  1.000 39.60000  ? 66  PHE A CG   1 
ATOM   966  C CD1  . PHE A 1 66  ? 28.85400 -10.52700 -7.59400  1.000 33.99000  ? 66  PHE A CD1  1 
ATOM   967  C CD2  . PHE A 1 66  ? 29.45900 -9.93400  -9.81900  1.000 39.85000  ? 66  PHE A CD2  1 
ATOM   968  C CE1  . PHE A 1 66  ? 29.50500 -9.40700  -7.12000  1.000 57.14000  ? 66  PHE A CE1  1 
ATOM   969  C CE2  . PHE A 1 66  ? 30.11700 -8.82100  -9.33800  1.000 46.91000  ? 66  PHE A CE2  1 
ATOM   970  C CZ   . PHE A 1 66  ? 30.13700 -8.55800  -7.99200  1.000 55.57000  ? 66  PHE A CZ   1 
ATOM   971  H H    . PHE A 1 66  ? 26.41800 -9.97200  -10.67300 1.000 48.60000  ? 66  PHE A H    1 
ATOM   972  H HA   . PHE A 1 66  ? 26.19100 -12.67600 -10.06400 1.000 66.85000  ? 66  PHE A HA   1 
ATOM   973  H HB2  . PHE A 1 66  ? 28.16000 -12.74400 -8.81600  1.000 46.81000  ? 66  PHE A HB2  1 
ATOM   974  H HB3  . PHE A 1 66  ? 28.52700 -12.32600 -10.30000 1.000 46.81000  ? 66  PHE A HB3  1 
ATOM   975  H HD1  . PHE A 1 66  ? 28.41600 -11.10500 -6.99000  1.000 40.66000  ? 66  PHE A HD1  1 
ATOM   976  H HD2  . PHE A 1 66  ? 29.44000 -10.10500 -10.74700 1.000 47.70000  ? 66  PHE A HD2  1 
ATOM   977  H HE1  . PHE A 1 66  ? 29.52600 -9.23400  -6.19200  1.000 68.44000  ? 66  PHE A HE1  1 
ATOM   978  H HE2  . PHE A 1 66  ? 30.54700 -8.23400  -9.93900  1.000 56.17000  ? 66  PHE A HE2  1 
ATOM   979  H HZ   . PHE A 1 66  ? 30.59200 -7.79900  -7.66400  1.000 66.56000  ? 66  PHE A HZ   1 
ATOM   980  N N    . ILE A 1 67  ? 25.65100 -12.32100 -7.64100  1.000 45.60000  ? 67  ILE A N    1 
ATOM   981  C CA   . ILE A 1 67  ? 25.23000 -12.06000 -6.24400  1.000 47.14000  ? 67  ILE A CA   1 
ATOM   982  C C    . ILE A 1 67  ? 26.42500 -12.63200 -5.46000  1.000 51.77000  ? 67  ILE A C    1 
ATOM   983  O O    . ILE A 1 67  ? 26.96700 -13.55200 -5.97400  1.000 37.31000  ? 67  ILE A O    1 
ATOM   984  C CB   . ILE A 1 67  ? 23.87400 -12.69600 -5.90300  1.000 39.31000  ? 67  ILE A CB   1 
ATOM   985  C CG1  . ILE A 1 67  ? 22.75900 -12.18700 -6.80700  1.000 40.27000  ? 67  ILE A CG1  1 
ATOM   986  C CG2  . ILE A 1 67  ? 23.53900 -12.47900 -4.43200  1.000 43.40000  ? 67  ILE A CG2  1 
ATOM   987  C CD1  . ILE A 1 67  ? 21.66600 -13.20000 -7.06900  1.000 30.09000  ? 67  ILE A CD1  1 
ATOM   988  H H    . ILE A 1 67  ? 25.67900 -13.19200 -7.87400  1.000 54.60000  ? 67  ILE A H    1 
ATOM   989  H HA   . ILE A 1 67  ? 25.17600 -11.10100 -6.09300  1.000 56.44000  ? 67  ILE A HA   1 
ATOM   990  H HB   . ILE A 1 67  ? 23.95600 -13.65900 -6.05200  1.000 47.05000  ? 67  ILE A HB   1 
ATOM   991  H HG12 . ILE A 1 67  ? 22.36000 -11.39400 -6.39400  1.000 48.20000  ? 67  ILE A HG12 1 
ATOM   992  H HG13 . ILE A 1 67  ? 23.14300 -11.91500 -7.66400  1.000 48.20000  ? 67  ILE A HG13 1 
ATOM   993  H HG21 . ILE A 1 67  ? 22.57700 -12.54500 -4.30400  1.000 51.95000  ? 67  ILE A HG21 1 
ATOM   994  H HG22 . ILE A 1 67  ? 23.98300 -13.15500 -3.89300  1.000 51.95000  ? 67  ILE A HG22 1 
ATOM   995  H HG23 . ILE A 1 67  ? 23.84100 -11.59700 -4.15800  1.000 51.95000  ? 67  ILE A HG23 1 
ATOM   996  H HD11 . ILE A 1 67  ? 21.08800 -12.88100 -7.78900  1.000 35.98000  ? 67  ILE A HD11 1 
ATOM   997  H HD12 . ILE A 1 67  ? 22.06700 -14.05100 -7.32800  1.000 35.98000  ? 67  ILE A HD12 1 
ATOM   998  H HD13 . ILE A 1 67  ? 21.13600 -13.32400 -6.25800  1.000 35.98000  ? 67  ILE A HD13 1 
ATOM   999  N N    . ARG A 1 68  ? 26.92000 -11.99000 -4.40800  1.000 39.73000  ? 68  ARG A N    1 
ATOM   1000 C CA   . ARG A 1 68  ? 28.09400 -12.41000 -3.64800  1.000 50.58000  ? 68  ARG A CA   1 
ATOM   1001 C C    . ARG A 1 68  ? 27.86800 -12.20900 -2.15000  1.000 45.39000  ? 68  ARG A C    1 
ATOM   1002 O O    . ARG A 1 68  ? 27.45900 -11.14100 -1.67100  1.000 37.83000  ? 68  ARG A O    1 
ATOM   1003 C CB   . ARG A 1 68  ? 29.35800 -11.65200 -4.10100  1.000 43.27000  ? 68  ARG A CB   1 
ATOM   1004 C CG   . ARG A 1 68  ? 30.64700 -12.25200 -3.68200  1.000 58.30000  ? 68  ARG A CG   1 
ATOM   1005 C CD   . ARG A 1 68  ? 31.84500 -11.52300 -4.26500  1.000 45.04000  ? 68  ARG A CD   1 
ATOM   1006 N NE   . ARG A 1 68  ? 31.89900 -11.60600 -5.71700  1.000 51.29000  ? 68  ARG A NE   1 
ATOM   1007 C CZ   . ARG A 1 68  ? 32.56700 -10.76100 -6.49100  1.000 43.99000  ? 68  ARG A CZ   1 
ATOM   1008 N NH1  . ARG A 1 68  ? 33.22600 -9.74000  -5.97200  1.000 52.59000  ? 68  ARG A NH1  1 
ATOM   1009 N NH2  . ARG A 1 68  ? 32.57400 -10.95400 -7.81300  1.000 43.07000  ? 68  ARG A NH2  1 
ATOM   1010 H H    . ARG A 1 68  ? 26.57800 -11.24200 -4.15800  1.000 47.55000  ? 68  ARG A H    1 
ATOM   1011 H HA   . ARG A 1 68  ? 28.22900 -13.35900 -3.79400  1.000 60.57000  ? 68  ARG A HA   1 
ATOM   1012 H HB2  . ARG A 1 68  ? 29.35900 -11.61400 -5.07000  1.000 51.80000  ? 68  ARG A HB2  1 
ATOM   1013 H HB3  . ARG A 1 68  ? 29.32400 -10.75500 -3.73400  1.000 51.80000  ? 68  ARG A HB3  1 
ATOM   1014 H HG2  . ARG A 1 68  ? 30.71400 -12.21500 -2.71500  1.000 69.84000  ? 68  ARG A HG2  1 
ATOM   1015 H HG3  . ARG A 1 68  ? 30.68100 -13.17300 -3.98200  1.000 69.84000  ? 68  ARG A HG3  1 
ATOM   1016 H HD2  . ARG A 1 68  ? 31.79500 -10.58600 -4.01900  1.000 53.93000  ? 68  ARG A HD2  1 
ATOM   1017 H HD3  . ARG A 1 68  ? 32.65800 -11.91600 -3.91100  1.000 53.93000  ? 68  ARG A HD3  1 
ATOM   1018 H HE   . ARG A 1 68  ? 31.46900 -12.24600 -6.09900  1.000 61.43000  ? 68  ARG A HE   1 
ATOM   1019 H HH11 . ARG A 1 68  ? 33.22600 -9.61500  -5.12100  1.000 62.98000  ? 68  ARG A HH11 1 
ATOM   1020 H HH12 . ARG A 1 68  ? 33.65600 -9.20000  -6.48600  1.000 62.98000  ? 68  ARG A HH12 1 
ATOM   1021 H HH21 . ARG A 1 68  ? 32.14900 -11.62000 -8.15300  1.000 51.56000  ? 68  ARG A HH21 1 
ATOM   1022 H HH22 . ARG A 1 68  ? 33.00400 -10.41300 -8.32500  1.000 51.56000  ? 68  ARG A HH22 1 
ATOM   1023 N N    . ILE A 1 69  ? 28.12400 -13.27500 -1.42000  1.000 37.01000  ? 69  ILE A N    1 
ATOM   1024 C CA   . ILE A 1 69  ? 27.90800 -13.33300 0.00800   1.000 34.56000  ? 69  ILE A CA   1 
ATOM   1025 C C    . ILE A 1 69  ? 29.27300 -13.39100 0.66700   1.000 43.27000  ? 69  ILE A C    1 
ATOM   1026 O O    . ILE A 1 69  ? 30.04100 -14.32400 0.39700   1.000 32.82000  ? 69  ILE A O    1 
ATOM   1027 C CB   . ILE A 1 69  ? 27.01500 -14.51000 0.39300   1.000 37.77000  ? 69  ILE A CB   1 
ATOM   1028 C CG1  . ILE A 1 69  ? 25.69600 -14.35700 -0.34400  1.000 53.41000  ? 69  ILE A CG1  1 
ATOM   1029 C CG2  . ILE A 1 69  ? 26.76100 -14.53300 1.87100   1.000 53.57000  ? 69  ILE A CG2  1 
ATOM   1030 C CD1  . ILE A 1 69  ? 24.76800 -15.54600 -0.18600  1.000 52.78000  ? 69  ILE A CD1  1 
ATOM   1031 H H    . ILE A 1 69  ? 28.43700 -14.00700 -1.74500  1.000 44.29000  ? 69  ILE A H    1 
ATOM   1032 H HA   . ILE A 1 69  ? 27.46500 -12.52800 0.31900   1.000 41.35000  ? 69  ILE A HA   1 
ATOM   1033 H HB   . ILE A 1 69  ? 27.45700 -15.33800 0.15000   1.000 45.20000  ? 69  ILE A HB   1 
ATOM   1034 H HG12 . ILE A 1 69  ? 25.23600 -13.57500 -0.00100  1.000 63.97000  ? 69  ILE A HG12 1 
ATOM   1035 H HG13 . ILE A 1 69  ? 25.87800 -14.24700 -1.29000  1.000 63.97000  ? 69  ILE A HG13 1 
ATOM   1036 H HG21 . ILE A 1 69  ? 26.16600 -15.27100 2.07700   1.000 64.17000  ? 69  ILE A HG21 1 
ATOM   1037 H HG22 . ILE A 1 69  ? 27.60500 -14.65000 2.33500   1.000 64.17000  ? 69  ILE A HG22 1 
ATOM   1038 H HG23 . ILE A 1 69  ? 26.35100 -13.69500 2.13400   1.000 64.17000  ? 69  ILE A HG23 1 
ATOM   1039 H HD11 . ILE A 1 69  ? 24.03400 -15.46000 -0.81400  1.000 63.21000  ? 69  ILE A HD11 1 
ATOM   1040 H HD12 . ILE A 1 69  ? 25.26400 -16.36000 -0.36700  1.000 63.21000  ? 69  ILE A HD12 1 
ATOM   1041 H HD13 . ILE A 1 69  ? 24.42700 -15.56200 0.72200   1.000 63.21000  ? 69  ILE A HD13 1 
ATOM   1042 N N    . ILE A 1 70  ? 29.58600 -12.35200 1.45900   1.000 29.12000  ? 70  ILE A N    1 
ATOM   1043 C CA   . ILE A 1 70  ? 30.92000 -12.13800 2.02700   1.000 32.15000  ? 70  ILE A CA   1 
ATOM   1044 C C    . ILE A 1 70  ? 30.88400 -12.03500 3.54500   1.000 46.61000  ? 70  ILE A C    1 
ATOM   1045 O O    . ILE A 1 70  ? 30.70400 -10.92900 4.07200   1.000 42.20000  ? 70  ILE A O    1 
ATOM   1046 C CB   . ILE A 1 70  ? 31.56200 -10.86700 1.45900   1.000 39.22000  ? 70  ILE A CB   1 
ATOM   1047 C CG1  . ILE A 1 70  ? 31.38900 -10.84300 -0.06900  1.000 56.32000  ? 70  ILE A CG1  1 
ATOM   1048 C CG2  . ILE A 1 70  ? 33.03300 -10.78800 1.86900   1.000 45.46000  ? 70  ILE A CG2  1 
ATOM   1049 C CD1  . ILE A 1 70  ? 31.01200 -9.45300  -0.61200  1.000 58.27000  ? 70  ILE A CD1  1 
ATOM   1050 H H    . ILE A 1 70  ? 29.02400 -11.74200 1.68600   1.000 34.81000  ? 70  ILE A H    1 
ATOM   1051 H HA   . ILE A 1 70  ? 31.44100 -12.92400 1.79900   1.000 38.46000  ? 70  ILE A HA   1 
ATOM   1052 H HB   . ILE A 1 70  ? 31.11700 -10.08600 1.82300   1.000 46.94000  ? 70  ILE A HB   1 
ATOM   1053 H HG12 . ILE A 1 70  ? 32.22300 -11.11000 -0.48400  1.000 67.47000  ? 70  ILE A HG12 1 
ATOM   1054 H HG13 . ILE A 1 70  ? 30.68300 -11.46100 -0.31500  1.000 67.47000  ? 70  ILE A HG13 1 
ATOM   1055 H HG21 . ILE A 1 70  ? 33.44000 -10.02000 1.43800   1.000 54.43000  ? 70  ILE A HG21 1 
ATOM   1056 H HG22 . ILE A 1 70  ? 33.08800 -10.69500 2.83300   1.000 54.43000  ? 70  ILE A HG22 1 
ATOM   1057 H HG23 . ILE A 1 70  ? 33.48300 -11.60100 1.58900   1.000 54.43000  ? 70  ILE A HG23 1 
ATOM   1058 H HD11 . ILE A 1 70  ? 30.90700 -9.50800  -1.57500  1.000 69.80000  ? 70  ILE A HD11 1 
ATOM   1059 H HD12 . ILE A 1 70  ? 30.17900 -9.16900  -0.20400  1.000 69.80000  ? 70  ILE A HD12 1 
ATOM   1060 H HD13 . ILE A 1 70  ? 31.71900 -8.82600  -0.39300  1.000 69.80000  ? 70  ILE A HD13 1 
ATOM   1061 N N    . PRO A 1 71  ? 31.01500 -13.14200 4.27400   1.000 45.01000  ? 71  PRO A N    1 
ATOM   1062 C CA   . PRO A 1 71  ? 31.12300 -13.05800 5.74300   1.000 43.20000  ? 71  PRO A CA   1 
ATOM   1063 C C    . PRO A 1 71  ? 32.41100 -12.38100 6.16800   1.000 42.68000  ? 71  PRO A C    1 
ATOM   1064 O O    . PRO A 1 71  ? 33.44900 -12.51600 5.50800   1.000 45.06000  ? 71  PRO A O    1 
ATOM   1065 C CB   . PRO A 1 71  ? 31.05000 -14.52600 6.20300   1.000 57.83000  ? 71  PRO A CB   1 
ATOM   1066 C CG   . PRO A 1 71  ? 31.19700 -15.35600 5.00400   1.000 36.60000  ? 71  PRO A CG   1 
ATOM   1067 C CD   . PRO A 1 71  ? 30.91500 -14.52700 3.77500   1.000 46.88000  ? 71  PRO A CD   1 
ATOM   1068 H HA   . PRO A 1 71  ? 30.37000 -12.57500 6.11900   1.000 51.72000  ? 71  PRO A HA   1 
ATOM   1069 H HB2  . PRO A 1 71  ? 31.76900 -14.70400 6.82900   1.000 69.27000  ? 71  PRO A HB2  1 
ATOM   1070 H HB3  . PRO A 1 71  ? 30.19300 -14.69000 6.62600   1.000 69.27000  ? 71  PRO A HB3  1 
ATOM   1071 H HG2  . PRO A 1 71  ? 32.10500 -15.69600 4.97000   1.000 43.79000  ? 71  PRO A HG2  1 
ATOM   1072 H HG3  . PRO A 1 71  ? 30.56800 -16.09200 5.05600   1.000 43.79000  ? 71  PRO A HG3  1 
ATOM   1073 H HD2  . PRO A 1 71  ? 31.57700 -14.69500 3.08600   1.000 56.13000  ? 71  PRO A HD2  1 
ATOM   1074 H HD3  . PRO A 1 71  ? 30.02600 -14.70800 3.43200   1.000 56.13000  ? 71  PRO A HD3  1 
ATOM   1075 N N    . GLN A 1 72  ? 32.30500 -11.54500 7.20200   1.000 40.28000  ? 72  GLN A N    1 
ATOM   1076 C CA   . GLN A 1 72  ? 33.44900 -10.84300 7.79200   1.000 43.94000  ? 72  GLN A CA   1 
ATOM   1077 C C    . GLN A 1 72  ? 33.49100 -11.15000 9.29200   1.000 55.61000  ? 72  GLN A C    1 
ATOM   1078 O O    . GLN A 1 72  ? 33.06600 -10.32900 10.11300  1.000 42.85000  ? 72  GLN A O    1 
ATOM   1079 C CB   . GLN A 1 72  ? 33.35400 -9.34100  7.54600   1.000 51.93000  ? 72  GLN A CB   1 
ATOM   1080 C CG   . GLN A 1 72  ? 33.00700 -8.99600  6.14400   1.000 57.17000  ? 72  GLN A CG   1 
ATOM   1081 C CD   . GLN A 1 72  ? 33.85900 -7.93100  5.56900   1.000 66.77000  ? 72  GLN A CD   1 
ATOM   1082 O OE1  . GLN A 1 72  ? 33.60200 -6.73400  5.77000   1.000 76.70000  ? 72  GLN A OE1  1 
ATOM   1083 N NE2  . GLN A 1 72  ? 34.92200 -8.35400  4.83500   1.000 82.81000  ? 72  GLN A NE2  1 
ATOM   1084 H H    . GLN A 1 72  ? 31.55900 -11.36300 7.59000   1.000 48.21000  ? 72  GLN A H    1 
ATOM   1085 H HA   . GLN A 1 72  ? 34.25900 -11.18100 7.38000   1.000 52.61000  ? 72  GLN A HA   1 
ATOM   1086 H HB2  . GLN A 1 72  ? 32.66700 -8.97200  8.12300   1.000 62.20000  ? 72  GLN A HB2  1 
ATOM   1087 H HB3  . GLN A 1 72  ? 34.21100 -8.93600  7.74900   1.000 62.20000  ? 72  GLN A HB3  1 
ATOM   1088 H HG2  . GLN A 1 72  ? 33.10800 -9.78700  5.59200   1.000 68.48000  ? 72  GLN A HG2  1 
ATOM   1089 H HG3  . GLN A 1 72  ? 32.08700 -8.68700  6.11600   1.000 68.48000  ? 72  GLN A HG3  1 
ATOM   1090 H HE21 . GLN A 1 72  ? 35.06300 -9.19600  4.73000   1.000 99.25000  ? 72  GLN A HE21 1 
ATOM   1091 H HE22 . GLN A 1 72  ? 35.45200 -7.78100  4.47600   1.000 99.25000  ? 72  GLN A HE22 1 
ATOM   1092 N N    . LYS A 1 73  ? 34.02400 -12.33300 9.64600   1.000 55.12000  ? 73  LYS A N    1 
ATOM   1093 C CA   . LYS A 1 73  ? 33.92800 -12.81200 11.02500  1.000 58.11000  ? 73  LYS A CA   1 
ATOM   1094 C C    . LYS A 1 73  ? 34.52800 -11.81000 11.99300  1.000 59.55000  ? 73  LYS A C    1 
ATOM   1095 O O    . LYS A 1 73  ? 33.97800 -11.55600 13.07300  1.000 56.69000  ? 73  LYS A O    1 
ATOM   1096 C CB   . LYS A 1 73  ? 34.62600 -14.16300 11.18300  1.000 56.22000  ? 73  LYS A CB   1 
ATOM   1097 C CG   . LYS A 1 73  ? 33.75800 -15.32300 10.78000  1.000 64.27000  ? 73  LYS A CG   1 
ATOM   1098 C CD   . LYS A 1 73  ? 34.54300 -16.48300 10.21500  1.000 75.81000  ? 73  LYS A CD   1 
ATOM   1099 C CE   . LYS A 1 73  ? 33.71900 -17.76700 10.22200  1.000 71.22000  ? 73  LYS A CE   1 
ATOM   1100 N NZ   . LYS A 1 73  ? 33.91400 -18.54200 11.47900  1.000 92.47000  ? 73  LYS A NZ   1 
ATOM   1101 H H    . LYS A 1 73  ? 34.43900 -12.86400 9.11300   1.000 66.02000  ? 73  LYS A H    1 
ATOM   1102 H HA   . LYS A 1 73  ? 32.99000 -12.93500 11.23700  1.000 69.61000  ? 73  LYS A HA   1 
ATOM   1103 H HB2  . LYS A 1 73  ? 35.41900 -14.17400 10.62500  1.000 67.34000  ? 73  LYS A HB2  1 
ATOM   1104 H HB3  . LYS A 1 73  ? 34.87400 -14.28300 12.11300  1.000 67.34000  ? 73  LYS A HB3  1 
ATOM   1105 H HG2  . LYS A 1 73  ? 33.27500 -15.64100 11.55900  1.000 77.00000  ? 73  LYS A HG2  1 
ATOM   1106 H HG3  . LYS A 1 73  ? 33.13200 -15.02800 10.10000  1.000 77.00000  ? 73  LYS A HG3  1 
ATOM   1107 H HD2  . LYS A 1 73  ? 34.79400 -16.28600 9.29900   1.000 90.85000  ? 73  LYS A HD2  1 
ATOM   1108 H HD3  . LYS A 1 73  ? 35.33700 -16.62600 10.75300  1.000 90.85000  ? 73  LYS A HD3  1 
ATOM   1109 H HE2  . LYS A 1 73  ? 32.77900 -17.54400 10.14500  1.000 85.34000  ? 73  LYS A HE2  1 
ATOM   1110 H HE3  . LYS A 1 73  ? 33.99000 -18.32500 9.47700   1.000 85.34000  ? 73  LYS A HE3  1 
ATOM   1111 H HZ1  . LYS A 1 73  ? 33.43000 -19.28900 11.45400  1.000 110.84000 ? 73  LYS A HZ1  1 
ATOM   1112 H HZ2  . LYS A 1 73  ? 34.77200 -18.75700 11.57500  1.000 110.84000 ? 73  LYS A HZ2  1 
ATOM   1113 H HZ3  . LYS A 1 73  ? 33.65800 -18.05500 12.17900  1.000 110.84000 ? 73  LYS A HZ3  1 
ATOM   1114 N N    . ASP A 1 74  ? 35.64300 -11.19900 11.60500  1.000 64.31000  ? 74  ASP A N    1 
ATOM   1115 C CA   . ASP A 1 74  ? 36.28600 -10.20500 12.45700  1.000 66.24000  ? 74  ASP A CA   1 
ATOM   1116 C C    . ASP A 1 74  ? 35.29800 -9.11200  12.87000  1.000 70.38000  ? 74  ASP A C    1 
ATOM   1117 O O    . ASP A 1 74  ? 35.19900 -8.77600  14.05300  1.000 59.92000  ? 74  ASP A O    1 
ATOM   1118 C CB   . ASP A 1 74  ? 37.49900 -9.62800  11.72000  1.000 41.08000  ? 74  ASP A CB   1 
ATOM   1119 C CG   . ASP A 1 74  ? 38.67500 -10.67900 11.54900  1.000 96.31000  ? 74  ASP A CG   1 
ATOM   1120 O OD1  . ASP A 1 74  ? 38.45400 -11.88700 11.87500  1.000 81.04000  ? 74  ASP A OD1  1 
ATOM   1121 O OD2  . ASP A 1 74  ? 39.80700 -10.29400 11.08400  1.000 83.25000  ? 74  ASP A OD2  1 
ATOM   1122 H H    . ASP A 1 74  ? 36.04500 -11.34100 10.85800  1.000 77.04000  ? 74  ASP A H    1 
ATOM   1123 H HA   . ASP A 1 74  ? 36.60300 -10.62300 13.27300  1.000 79.37000  ? 74  ASP A HA   1 
ATOM   1124 H HB2  . ASP A 1 74  ? 37.22300 -9.34100  10.83500  1.000 49.17000  ? 74  ASP A HB2  1 
ATOM   1125 H HB3  . ASP A 1 74  ? 37.84300 -8.87200  12.22100  1.000 49.17000  ? 74  ASP A HB3  1 
ATOM   1126 N N    . GLN A 1 75  ? 34.51900 -8.57100  11.92200  1.000 56.18000  ? 75  GLN A N    1 
ATOM   1127 C CA   . GLN A 1 75  ? 33.64000 -7.44600  12.26700  1.000 48.23000  ? 75  GLN A CA   1 
ATOM   1128 C C    . GLN A 1 75  ? 32.21400 -7.83900  12.68100  1.000 51.73000  ? 75  GLN A C    1 
ATOM   1129 O O    . GLN A 1 75  ? 31.38600 -6.93800  12.95300  1.000 51.42000  ? 75  GLN A O    1 
ATOM   1130 C CB   . GLN A 1 75  ? 33.51500 -6.45900  11.11100  1.000 50.69000  ? 75  GLN A CB   1 
ATOM   1131 C CG   . GLN A 1 75  ? 34.79500 -5.79600  10.74100  1.000 48.93000  ? 75  GLN A CG   1 
ATOM   1132 C CD   . GLN A 1 75  ? 35.50700 -6.53200  9.59300   1.000 84.85000  ? 75  GLN A CD   1 
ATOM   1133 O OE1  . GLN A 1 75  ? 36.26700 -7.51000  9.80200   1.000 72.67000  ? 75  GLN A OE1  1 
ATOM   1134 N NE2  . GLN A 1 75  ? 35.22400 -6.08100  8.35600   1.000 76.91000  ? 75  GLN A NE2  1 
ATOM   1135 H H    . GLN A 1 75  ? 34.48400 -8.82900  11.10300  1.000 67.29000  ? 75  GLN A H    1 
ATOM   1136 H HA   . GLN A 1 75  ? 34.07000 -7.00800  13.01800  1.000 57.75000  ? 75  GLN A HA   1 
ATOM   1137 H HB2  . GLN A 1 75  ? 33.19100 -6.93300  10.33000  1.000 60.71000  ? 75  GLN A HB2  1 
ATOM   1138 H HB3  . GLN A 1 75  ? 32.88500 -5.76500  11.36200  1.000 60.71000  ? 75  GLN A HB3  1 
ATOM   1139 H HG2  . GLN A 1 75  ? 34.61400 -4.88800  10.45400  1.000 58.60000  ? 75  GLN A HG2  1 
ATOM   1140 H HG3  . GLN A 1 75  ? 35.38600 -5.79000  11.51000  1.000 58.60000  ? 75  GLN A HG3  1 
ATOM   1141 H HE21 . GLN A 1 75  ? 34.67800 -5.42500  8.25200   1.000 92.17000  ? 75  GLN A HE21 1 
ATOM   1142 H HE22 . GLN A 1 75  ? 35.58900 -6.45000  7.67100   1.000 92.17000  ? 75  GLN A HE22 1 
ATOM   1143 N N    . LYS A 1 76  ? 31.90500 -9.14100  12.72200  1.000 51.16000  ? 76  LYS A N    1 
ATOM   1144 C CA   . LYS A 1 76  ? 30.53400 -9.61900  12.93700  1.000 62.78000  ? 76  LYS A CA   1 
ATOM   1145 C C    . LYS A 1 76  ? 29.60500 -8.99500  11.90500  1.000 59.86000  ? 76  LYS A C    1 
ATOM   1146 O O    . LYS A 1 76  ? 28.52600 -8.46000  12.20000  1.000 51.13000  ? 76  LYS A O    1 
ATOM   1147 C CB   . LYS A 1 76  ? 30.09900 -9.35000  14.37100  1.000 59.48000  ? 76  LYS A CB   1 
ATOM   1148 C CG   . LYS A 1 76  ? 31.03900 -10.07500 15.36600  1.000 76.36000  ? 76  LYS A CG   1 
ATOM   1149 C CD   . LYS A 1 76  ? 30.53600 -10.09900 16.79400  1.000 83.59000  ? 76  LYS A CD   1 
ATOM   1150 C CE   . LYS A 1 76  ? 31.56800 -9.53300  17.77600  1.000 87.66000  ? 76  LYS A CE   1 
ATOM   1151 N NZ   . LYS A 1 76  ? 31.32400 -10.04700 19.14900  1.000 89.32000  ? 76  LYS A NZ   1 
ATOM   1152 H H    . LYS A 1 76  ? 32.47900 -9.77400  12.62700  1.000 61.27000  ? 76  LYS A H    1 
ATOM   1153 H HA   . LYS A 1 76  ? 30.48700 -10.58000 12.81000  1.000 75.21000  ? 76  LYS A HA   1 
ATOM   1154 H HB2  . LYS A 1 76  ? 30.13500 -8.39700  14.54800  1.000 71.26000  ? 76  LYS A HB2  1 
ATOM   1155 H HB3  . LYS A 1 76  ? 29.19600 -9.67800  14.50300  1.000 71.26000  ? 76  LYS A HB3  1 
ATOM   1156 H HG2  . LYS A 1 76  ? 31.14700 -10.99500 15.07800  1.000 91.51000  ? 76  LYS A HG2  1 
ATOM   1157 H HG3  . LYS A 1 76  ? 31.89800 -9.62400  15.36600  1.000 91.51000  ? 76  LYS A HG3  1 
ATOM   1158 H HD2  . LYS A 1 76  ? 29.73100 -9.56100  16.85800  1.000 100.18000 ? 76  LYS A HD2  1 
ATOM   1159 H HD3  . LYS A 1 76  ? 30.34500 -11.01500 17.04900  1.000 100.18000 ? 76  LYS A HD3  1 
ATOM   1160 H HE2  . LYS A 1 76  ? 32.45900 -9.80100  17.50100  1.000 105.06000 ? 76  LYS A HE2  1 
ATOM   1161 H HE3  . LYS A 1 76  ? 31.50400 -8.56600  17.79300  1.000 105.06000 ? 76  LYS A HE3  1 
ATOM   1162 H HZ1  . LYS A 1 76  ? 31.90300 -9.68400  19.71800  1.000 107.07000 ? 76  LYS A HZ1  1 
ATOM   1163 H HZ2  . LYS A 1 76  ? 30.49700 -9.84200  19.40900  1.000 107.07000 ? 76  LYS A HZ2  1 
ATOM   1164 H HZ3  . LYS A 1 76  ? 31.42000 -10.93200 19.16500  1.000 107.07000 ? 76  LYS A HZ3  1 
ATOM   1165 N N    . VAL A 1 77  ? 30.05400 -9.07700  10.65600  1.000 48.80000  ? 77  VAL A N    1 
ATOM   1166 C CA   . VAL A 1 77  ? 29.35700 -8.48700  9.52500   1.000 53.86000  ? 77  VAL A CA   1 
ATOM   1167 C C    . VAL A 1 77  ? 29.16600 -9.54700  8.43300   1.000 48.15000  ? 77  VAL A C    1 
ATOM   1168 O O    . VAL A 1 77  ? 30.09400 -10.29400 8.09600   1.000 38.59000  ? 77  VAL A O    1 
ATOM   1169 C CB   . VAL A 1 77  ? 30.10200 -7.23300  8.99600   1.000 47.02000  ? 77  VAL A CB   1 
ATOM   1170 C CG1  . VAL A 1 77  ? 29.62900 -6.94200  7.61300   1.000 39.54000  ? 77  VAL A CG1  1 
ATOM   1171 C CG2  . VAL A 1 77  ? 29.88100 -6.04100  9.95500   1.000 57.53000  ? 77  VAL A CG2  1 
ATOM   1172 H H    . VAL A 1 77  ? 30.78100 -9.48100  10.43700  1.000 58.44000  ? 77  VAL A H    1 
ATOM   1173 H HA   . VAL A 1 77  ? 28.46900 -8.21100  9.80200   1.000 64.51000  ? 77  VAL A HA   1 
ATOM   1174 H HB   . VAL A 1 77  ? 31.05900 -7.38800  8.95900   1.000 56.30000  ? 77  VAL A HB   1 
ATOM   1175 H HG11 . VAL A 1 77  ? 29.99400 -6.09000  7.32700   1.000 47.32000  ? 77  VAL A HG11 1 
ATOM   1176 H HG12 . VAL A 1 77  ? 29.93200 -7.64700  7.02000   1.000 47.32000  ? 77  VAL A HG12 1 
ATOM   1177 H HG13 . VAL A 1 77  ? 28.65900 -6.90300  7.61200   1.000 47.32000  ? 77  VAL A HG13 1 
ATOM   1178 H HG21 . VAL A 1 77  ? 30.38400 -5.27800  9.63100   1.000 68.91000  ? 77  VAL A HG21 1 
ATOM   1179 H HG22 . VAL A 1 77  ? 28.93600 -5.82800  9.98200   1.000 68.91000  ? 77  VAL A HG22 1 
ATOM   1180 H HG23 . VAL A 1 77  ? 30.19000 -6.28800  10.84100  1.000 68.91000  ? 77  VAL A HG23 1 
ATOM   1181 N N    . LEU A 1 78  ? 27.97100 -9.58000  7.85000   1.000 37.82000  ? 78  LEU A N    1 
ATOM   1182 C CA   . LEU A 1 78  ? 27.67700 -10.38000 6.65900   1.000 38.62000  ? 78  LEU A CA   1 
ATOM   1183 C C    . LEU A 1 78  ? 27.31500 -9.39000  5.55500   1.000 46.02000  ? 78  LEU A C    1 
ATOM   1184 O O    . LEU A 1 78  ? 26.40400 -8.57600  5.75100   1.000 34.24000  ? 78  LEU A O    1 
ATOM   1185 C CB   . LEU A 1 78  ? 26.53400 -11.35800 6.92900   1.000 34.26000  ? 78  LEU A CB   1 
ATOM   1186 C CG   . LEU A 1 78  ? 26.11300 -12.22700 5.74700   1.000 44.86000  ? 78  LEU A CG   1 
ATOM   1187 C CD1  . LEU A 1 78  ? 27.20600 -13.19400 5.31000   1.000 43.38000  ? 78  LEU A CD1  1 
ATOM   1188 C CD2  . LEU A 1 78  ? 24.87200 -13.00000 6.06800   1.000 34.88000  ? 78  LEU A CD2  1 
ATOM   1189 H H    . LEU A 1 78  ? 27.29200 -9.13500  8.13400   1.000 45.26000  ? 78  LEU A H    1 
ATOM   1190 H HA   . LEU A 1 78  ? 28.44500 -10.90500 6.38400   1.000 46.23000  ? 78  LEU A HA   1 
ATOM   1191 H HB2  . LEU A 1 78  ? 26.80700 -11.95400 7.64300   1.000 40.99000  ? 78  LEU A HB2  1 
ATOM   1192 H HB3  . LEU A 1 78  ? 25.75600 -10.84700 7.20300   1.000 40.99000  ? 78  LEU A HB3  1 
ATOM   1193 H HG   . LEU A 1 78  ? 25.93800 -11.62700 5.00600   1.000 53.70000  ? 78  LEU A HG   1 
ATOM   1194 H HD11 . LEU A 1 78  ? 26.85500 -13.77700 4.61900   1.000 51.93000  ? 78  LEU A HD11 1 
ATOM   1195 H HD12 . LEU A 1 78  ? 27.95700 -12.68600 4.96400   1.000 51.93000  ? 78  LEU A HD12 1 
ATOM   1196 H HD13 . LEU A 1 78  ? 27.48700 -13.72000 6.07500   1.000 51.93000  ? 78  LEU A HD13 1 
ATOM   1197 H HD21 . LEU A 1 78  ? 24.64000 -13.55600 5.30800   1.000 41.74000  ? 78  LEU A HD21 1 
ATOM   1198 H HD22 . LEU A 1 78  ? 25.03800 -13.55500 6.84600   1.000 41.74000  ? 78  LEU A HD22 1 
ATOM   1199 H HD23 . LEU A 1 78  ? 24.15200 -12.37700 6.25400   1.000 41.74000  ? 78  LEU A HD23 1 
ATOM   1200 N N    . GLU A 1 79  ? 28.06400 -9.41200  4.44000   1.000 27.46000  ? 79  GLU A N    1 
ATOM   1201 C CA   . GLU A 1 79  ? 27.82500 -8.53900  3.30700   1.000 36.76000  ? 79  GLU A CA   1 
ATOM   1202 C C    . GLU A 1 79  ? 27.16700 -9.34400  2.21200   1.000 39.58000  ? 79  GLU A C    1 
ATOM   1203 O O    . GLU A 1 79  ? 27.57200 -10.48300 1.95900   1.000 36.35000  ? 79  GLU A O    1 
ATOM   1204 C CB   . GLU A 1 79  ? 29.11200 -7.93000  2.77300   1.000 30.85000  ? 79  GLU A CB   1 
ATOM   1205 C CG   . GLU A 1 79  ? 29.94200 -7.16900  3.82500   1.000 50.90000  ? 79  GLU A CG   1 
ATOM   1206 C CD   . GLU A 1 79  ? 31.28900 -6.71700  3.27400   1.000 32.70000  ? 79  GLU A CD   1 
ATOM   1207 O OE1  . GLU A 1 79  ? 31.97900 -7.54200  2.58600   1.000 40.54000  ? 79  GLU A OE1  1 
ATOM   1208 O OE2  . GLU A 1 79  ? 31.65200 -5.54500  3.55100   1.000 38.65000  ? 79  GLU A OE2  1 
ATOM   1209 H H    . GLU A 1 79  ? 28.73100 -9.94200  4.32500   1.000 32.83000  ? 79  GLU A H    1 
ATOM   1210 H HA   . GLU A 1 79  ? 27.24600 -7.81300  3.58700   1.000 43.99000  ? 79  GLU A HA   1 
ATOM   1211 H HB2  . GLU A 1 79  ? 29.66700 -8.64100  2.41900   1.000 36.90000  ? 79  GLU A HB2  1 
ATOM   1212 H HB3  . GLU A 1 79  ? 28.88700 -7.30200  2.06800   1.000 36.90000  ? 79  GLU A HB3  1 
ATOM   1213 H HG2  . GLU A 1 79  ? 29.45200 -6.38300  4.11000   1.000 60.96000  ? 79  GLU A HG2  1 
ATOM   1214 H HG3  . GLU A 1 79  ? 30.10600 -7.75200  4.58300   1.000 60.96000  ? 79  GLU A HG3  1 
ATOM   1215 N N    . ILE A 1 80  ? 26.11900 -8.76900  1.62000   1.000 32.21000  ? 80  ILE A N    1 
ATOM   1216 C CA   . ILE A 1 80  ? 25.44800 -9.30100  0.45500   1.000 37.05000  ? 80  ILE A CA   1 
ATOM   1217 C C    . ILE A 1 80  ? 25.59000 -8.26000  -0.62600  1.000 31.56000  ? 80  ILE A C    1 
ATOM   1218 O O    . ILE A 1 80  ? 24.98500 -7.17800  -0.54400  1.000 29.48000  ? 80  ILE A O    1 
ATOM   1219 C CB   . ILE A 1 80  ? 23.97600 -9.63100  0.73000   1.000 34.65000  ? 80  ILE A CB   1 
ATOM   1220 C CG1  . ILE A 1 80  ? 23.95600 -10.67300 1.85700   1.000 47.11000  ? 80  ILE A CG1  1 
ATOM   1221 C CG2  . ILE A 1 80  ? 23.29700 -10.19500 -0.55500  1.000 31.63000  ? 80  ILE A CG2  1 
ATOM   1222 C CD1  . ILE A 1 80  ? 22.99300 -10.42300 2.91200   1.000 65.06000  ? 80  ILE A CD1  1 
ATOM   1223 H H    . ILE A 1 80  ? 25.76800 -8.03300  1.89600   1.000 38.53000  ? 80  ILE A H    1 
ATOM   1224 H HA   . ILE A 1 80  ? 25.88100 -10.11900 0.16500   1.000 44.33000  ? 80  ILE A HA   1 
ATOM   1225 H HB   . ILE A 1 80  ? 23.48700 -8.83600  0.99000   1.000 41.46000  ? 80  ILE A HB   1 
ATOM   1226 H HG12 . ILE A 1 80  ? 23.74500 -11.53800 1.47100   1.000 56.41000  ? 80  ILE A HG12 1 
ATOM   1227 H HG13 . ILE A 1 80  ? 24.83500 -10.69800 2.26700   1.000 56.41000  ? 80  ILE A HG13 1 
ATOM   1228 H HG21 . ILE A 1 80  ? 22.42900 -10.55800 -0.31900  1.000 37.83000  ? 80  ILE A HG21 1 
ATOM   1229 H HG22 . ILE A 1 80  ? 23.19200 -9.47600  -1.19700  1.000 37.83000  ? 80  ILE A HG22 1 
ATOM   1230 H HG23 . ILE A 1 80  ? 23.85700 -10.89300 -0.92800  1.000 37.83000  ? 80  ILE A HG23 1 
ATOM   1231 H HD11 . ILE A 1 80  ? 23.12400 -11.07300 3.62000   1.000 77.95000  ? 80  ILE A HD11 1 
ATOM   1232 H HD12 . ILE A 1 80  ? 23.12900 -9.52700  3.25700   1.000 77.95000  ? 80  ILE A HD12 1 
ATOM   1233 H HD13 . ILE A 1 80  ? 22.09800 -10.50600 2.54900   1.000 77.95000  ? 80  ILE A HD13 1 
ATOM   1234 N N    . ARG A 1 81  ? 26.40400 -8.57600  -1.62200  1.000 32.39000  ? 81  ARG A N    1 
ATOM   1235 C CA   . ARG A 1 81  ? 26.69100 -7.71300  -2.74000  1.000 45.99000  ? 81  ARG A CA   1 
ATOM   1236 C C    . ARG A 1 81  ? 26.09300 -8.23000  -4.04000  1.000 45.05000  ? 81  ARG A C    1 
ATOM   1237 O O    . ARG A 1 81  ? 26.12100 -9.42600  -4.34100  1.000 36.62000  ? 81  ARG A O    1 
ATOM   1238 C CB   . ARG A 1 81  ? 28.21100 -7.57300  -2.91600  1.000 47.10000  ? 81  ARG A CB   1 
ATOM   1239 C CG   . ARG A 1 81  ? 28.63600 -6.88900  -4.20700  1.000 40.87000  ? 81  ARG A CG   1 
ATOM   1240 C CD   . ARG A 1 81  ? 30.10000 -6.64300  -4.22000  1.000 49.41000  ? 81  ARG A CD   1 
ATOM   1241 N NE   . ARG A 1 81  ? 30.57400 -5.94000  -5.40800  1.000 53.96000  ? 81  ARG A NE   1 
ATOM   1242 C CZ   . ARG A 1 81  ? 31.85400 -5.74400  -5.70500  1.000 67.17000  ? 81  ARG A CZ   1 
ATOM   1243 N NH1  . ARG A 1 81  ? 32.82100 -6.27600  -4.96900  1.000 49.03000  ? 81  ARG A NH1  1 
ATOM   1244 N NH2  . ARG A 1 81  ? 32.16800 -4.97000  -6.74700  1.000 64.62000  ? 81  ARG A NH2  1 
ATOM   1245 H H    . ARG A 1 81  ? 26.82200 -9.32700  -1.66800  1.000 38.75000  ? 81  ARG A H    1 
ATOM   1246 H HA   . ARG A 1 81  ? 26.28400 -6.85000  -2.56700  1.000 55.06000  ? 81  ARG A HA   1 
ATOM   1247 H HB2  . ARG A 1 81  ? 28.56000 -7.05000  -2.17800  1.000 56.40000  ? 81  ARG A HB2  1 
ATOM   1248 H HB3  . ARG A 1 81  ? 28.60600 -8.45900  -2.91000  1.000 56.40000  ? 81  ARG A HB3  1 
ATOM   1249 H HG2  . ARG A 1 81  ? 28.41200 -7.45500  -4.96200  1.000 48.92000  ? 81  ARG A HG2  1 
ATOM   1250 H HG3  . ARG A 1 81  ? 28.18000 -6.03600  -4.28600  1.000 48.92000  ? 81  ARG A HG3  1 
ATOM   1251 H HD2  . ARG A 1 81  ? 30.33200 -6.10600  -3.44700  1.000 59.17000  ? 81  ARG A HD2  1 
ATOM   1252 H HD3  . ARG A 1 81  ? 30.55900 -7.49700  -4.18100  1.000 59.17000  ? 81  ARG A HD3  1 
ATOM   1253 H HE   . ARG A 1 81  ? 29.98400 -5.63100  -5.95300  1.000 64.62000  ? 81  ARG A HE   1 
ATOM   1254 H HH11 . ARG A 1 81  ? 32.62400 -6.75900  -4.28500  1.000 58.71000  ? 81  ARG A HH11 1 
ATOM   1255 H HH12 . ARG A 1 81  ? 33.64400 -6.13900  -5.17600  1.000 58.71000  ? 81  ARG A HH12 1 
ATOM   1256 H HH21 . ARG A 1 81  ? 31.54500 -4.60600  -7.21600  1.000 77.42000  ? 81  ARG A HH21 1 
ATOM   1257 H HH22 . ARG A 1 81  ? 32.99300 -4.83500  -6.95000  1.000 77.42000  ? 81  ARG A HH22 1 
ATOM   1258 N N    . ASP A 1 82  ? 25.61100 -7.30800  -4.83400  1.000 33.45000  ? 82  ASP A N    1 
ATOM   1259 C CA   . ASP A 1 82  ? 25.14300 -7.61200  -6.18500  1.000 46.28000  ? 82  ASP A CA   1 
ATOM   1260 C C    . ASP A 1 82  ? 25.74900 -6.61300  -7.14500  1.000 35.21000  ? 82  ASP A C    1 
ATOM   1261 O O    . ASP A 1 82  ? 26.09000 -5.49800  -6.75700  1.000 51.54000  ? 82  ASP A O    1 
ATOM   1262 C CB   . ASP A 1 82  ? 23.59000 -7.61500  -6.32400  1.000 34.55000  ? 82  ASP A CB   1 
ATOM   1263 C CG   . ASP A 1 82  ? 22.94400 -6.25700  -6.11900  1.000 32.94000  ? 82  ASP A CG   1 
ATOM   1264 O OD1  . ASP A 1 82  ? 23.03300 -5.40500  -7.03100  1.000 41.54000  ? 82  ASP A OD1  1 
ATOM   1265 O OD2  . ASP A 1 82  ? 22.32600 -6.05500  -5.04200  1.000 47.31000  ? 82  ASP A OD2  1 
ATOM   1266 H H    . ASP A 1 82  ? 25.53900 -6.47900  -4.62000  1.000 40.02000  ? 82  ASP A H    1 
ATOM   1267 H HA   . ASP A 1 82  ? 25.43700 -8.50600  -6.42200  1.000 55.42000  ? 82  ASP A HA   1 
ATOM   1268 H HB2  . ASP A 1 82  ? 23.35900 -7.91800  -7.21600  1.000 41.33000  ? 82  ASP A HB2  1 
ATOM   1269 H HB3  . ASP A 1 82  ? 23.22000 -8.21900  -5.66100  1.000 41.33000  ? 82  ASP A HB3  1 
ATOM   1270 N N    . SER A 1 83  ? 25.91800 -7.03000  -8.39300  1.000 33.46000  ? 83  SER A N    1 
ATOM   1271 C CA   . SER A 1 83  ? 26.25700 -6.10300  -9.48300  1.000 49.61000  ? 83  SER A CA   1 
ATOM   1272 C C    . SER A 1 83  ? 24.99500 -5.74300  -10.29600 1.000 55.28000  ? 83  SER A C    1 
ATOM   1273 O O    . SER A 1 83  ? 24.96000 -5.74600  -11.52900 1.000 50.26000  ? 83  SER A O    1 
ATOM   1274 C CB   . SER A 1 83  ? 27.36500 -6.71300  -10.35200 1.000 38.15000  ? 83  SER A CB   1 
ATOM   1275 O OG   . SER A 1 83  ? 26.94300 -7.94900  -10.89500 1.000 43.43000  ? 83  SER A OG   1 
ATOM   1276 H H    . SER A 1 83  ? 25.84200 -7.85000  -8.64200  1.000 40.02000  ? 83  SER A H    1 
ATOM   1277 H HA   . SER A 1 83  ? 26.60900 -5.27500  -9.12000  1.000 59.40000  ? 83  SER A HA   1 
ATOM   1278 H HB2  . SER A 1 83  ? 27.57100 -6.10200  -11.07700 1.000 45.66000  ? 83  SER A HB2  1 
ATOM   1279 H HB3  . SER A 1 83  ? 28.15300 -6.85800  -9.80600  1.000 45.66000  ? 83  SER A HB3  1 
ATOM   1280 H HG   . SER A 1 83  ? 26.19900 -7.85800  -11.27400 1.000 51.99000  ? 83  SER A HG   1 
ATOM   1281 N N    . GLY A 1 84  ? 23.89900 -5.46700  -9.60600  1.000 61.42000  ? 84  GLY A N    1 
ATOM   1282 C CA   . GLY A 1 84  ? 22.68600 -5.05200  -10.27200 1.000 56.12000  ? 84  GLY A CA   1 
ATOM   1283 C C    . GLY A 1 84  ? 22.69600 -3.58400  -10.65100 1.000 44.21000  ? 84  GLY A C    1 
ATOM   1284 O O    . GLY A 1 84  ? 23.73900 -2.93200  -10.73100 1.000 42.60000  ? 84  GLY A O    1 
ATOM   1285 H H    . GLY A 1 84  ? 23.83700 -5.51500  -8.74900  1.000 73.58000  ? 84  GLY A H    1 
ATOM   1286 H HA2  . GLY A 1 84  ? 22.57200 -5.57400  -11.08100 1.000 67.22000  ? 84  GLY A HA2  1 
ATOM   1287 H HA3  . GLY A 1 84  ? 21.93000 -5.21000  -9.68500  1.000 67.22000  ? 84  GLY A HA3  1 
ATOM   1288 N N    . ILE A 1 85  ? 21.49500 -3.04700  -10.83600 1.000 41.22000  ? 85  ILE A N    1 
ATOM   1289 C CA   . ILE A 1 85  ? 21.37900 -1.69200  -11.36400 1.000 39.68000  ? 85  ILE A CA   1 
ATOM   1290 C C    . ILE A 1 85  ? 21.96500 -0.67000  -10.40300 1.000 42.99000  ? 85  ILE A C    1 
ATOM   1291 O O    . ILE A 1 85  ? 22.41200 0.39800   -10.81100 1.000 54.10000  ? 85  ILE A O    1 
ATOM   1292 C CB   . ILE A 1 85  ? 19.89900 -1.37800  -11.69500 1.000 65.55000  ? 85  ILE A CB   1 
ATOM   1293 C CG1  . ILE A 1 85  ? 19.78500 0.00000   -12.36400 1.000 61.09000  ? 85  ILE A CG1  1 
ATOM   1294 C CG2  . ILE A 1 85  ? 19.02300 -1.45300  -10.43800 1.000 51.77000  ? 85  ILE A CG2  1 
ATOM   1295 C CD1  . ILE A 1 85  ? 18.88700 -0.00500  -13.58300 1.000 73.18000  ? 85  ILE A CD1  1 
ATOM   1296 H H    . ILE A 1 85  ? 20.74700 -3.43600  -10.66700 1.000 49.34000  ? 85  ILE A H    1 
ATOM   1297 H HA   . ILE A 1 85  ? 21.89300 -1.64200  -12.18500 1.000 47.49000  ? 85  ILE A HA   1 
ATOM   1298 H HB   . ILE A 1 85  ? 19.57900 -2.05000  -12.31700 1.000 78.53000  ? 85  ILE A HB   1 
ATOM   1299 H HG12 . ILE A 1 85  ? 19.41800 0.63100   -11.72500 1.000 73.19000  ? 85  ILE A HG12 1 
ATOM   1300 H HG13 . ILE A 1 85  ? 20.66800 0.28800   -12.64400 1.000 73.19000  ? 85  ILE A HG13 1 
ATOM   1301 H HG21 . ILE A 1 85  ? 18.10500 -1.25200  -10.68100 1.000 62.00000  ? 85  ILE A HG21 1 
ATOM   1302 H HG22 . ILE A 1 85  ? 19.07800 -2.34800  -10.06800 1.000 62.00000  ? 85  ILE A HG22 1 
ATOM   1303 H HG23 . ILE A 1 85  ? 19.34300 -0.80700  -9.79100  1.000 62.00000  ? 85  ILE A HG23 1 
ATOM   1304 H HD11 . ILE A 1 85  ? 18.85700 0.89000   -13.95700 1.000 87.70000  ? 85  ILE A HD11 1 
ATOM   1305 H HD12 . ILE A 1 85  ? 19.24500 -0.62500  -14.23700 1.000 87.70000  ? 85  ILE A HD12 1 
ATOM   1306 H HD13 . ILE A 1 85  ? 17.99600 -0.28200  -13.31800 1.000 87.70000  ? 85  ILE A HD13 1 
ATOM   1307 N N    . GLY A 1 86  ? 21.95200 -0.95000  -9.13200  1.000 47.09000  ? 86  GLY A N    1 
ATOM   1308 C CA   . GLY A 1 86  ? 22.31300 0.08800   -8.18400  1.000 49.73000  ? 86  GLY A CA   1 
ATOM   1309 C C    . GLY A 1 86  ? 21.21000 1.14600   -8.02000  1.000 55.81000  ? 86  GLY A C    1 
ATOM   1310 O O    . GLY A 1 86  ? 20.15400 1.13500   -8.67400  1.000 45.45000  ? 86  GLY A O    1 
ATOM   1311 H H    . GLY A 1 86  ? 21.74500 -1.71100  -8.79000  1.000 56.39000  ? 86  GLY A H    1 
ATOM   1312 H HA2  . GLY A 1 86  ? 22.48100 -0.31400  -7.31800  1.000 59.55000  ? 86  GLY A HA2  1 
ATOM   1313 H HA3  . GLY A 1 86  ? 23.11900 0.53300   -8.48800  1.000 59.55000  ? 86  GLY A HA3  1 
ATOM   1314 N N    . MET A 1 87  ? 21.47200 2.05700   -7.07900  1.000 40.34000  ? 87  MET A N    1 
ATOM   1315 C CA   . MET A 1 87  ? 20.52900 3.08200   -6.64100  1.000 54.36000  ? 87  MET A CA   1 
ATOM   1316 C C    . MET A 1 87  ? 21.25400 4.43300   -6.65500  1.000 56.52000  ? 87  MET A C    1 
ATOM   1317 O O    . MET A 1 87  ? 22.31900 4.58800   -6.03900  1.000 65.11000  ? 87  MET A O    1 
ATOM   1318 C CB   . MET A 1 87  ? 19.99400 2.74500   -5.22000  1.000 47.43000  ? 87  MET A CB   1 
ATOM   1319 C CG   . MET A 1 87  ? 19.41800 1.31500   -5.03900  1.000 54.98000  ? 87  MET A CG   1 
ATOM   1320 S SD   . MET A 1 87  ? 18.63000 1.08700   -3.43400  1.000 52.33000  ? 87  MET A SD   1 
ATOM   1321 C CE   . MET A 1 87  ? 18.49100 2.72900   -2.87400  1.000 57.36000  ? 87  MET A CE   1 
ATOM   1322 H H    . MET A 1 87  ? 22.22300 2.10200   -6.66300  1.000 48.28000  ? 87  MET A H    1 
ATOM   1323 H HA   . MET A 1 87  ? 19.76800 3.13100   -7.24000  1.000 65.11000  ? 87  MET A HA   1 
ATOM   1324 H HB2  . MET A 1 87  ? 20.72400 2.84300   -4.58900  1.000 56.79000  ? 87  MET A HB2  1 
ATOM   1325 H HB3  . MET A 1 87  ? 19.28400 3.37000   -5.00600  1.000 56.79000  ? 87  MET A HB3  1 
ATOM   1326 H HG2  . MET A 1 87  ? 18.75300 1.15100   -5.72600  1.000 65.85000  ? 87  MET A HG2  1 
ATOM   1327 H HG3  . MET A 1 87  ? 20.13900 0.67000   -5.11400  1.000 65.85000  ? 87  MET A HG3  1 
ATOM   1328 H HE1  . MET A 1 87  ? 18.15400 2.72500   -1.96400  1.000 68.71000  ? 87  MET A HE1  1 
ATOM   1329 H HE2  . MET A 1 87  ? 19.36600 3.14700   -2.90100  1.000 68.71000  ? 87  MET A HE2  1 
ATOM   1330 H HE3  . MET A 1 87  ? 17.87700 3.20900   -3.45200  1.000 68.71000  ? 87  MET A HE3  1 
ATOM   1331 N N    . THR A 1 88  ? 20.68400 5.40800   -7.35800  1.000 55.21000  ? 88  THR A N    1 
ATOM   1332 C CA   . THR A 1 88  ? 21.20000 6.77500   -7.29400  1.000 52.42000  ? 88  THR A CA   1 
ATOM   1333 C C    . THR A 1 88  ? 21.09600 7.35200   -5.86200  1.000 51.40000  ? 88  THR A C    1 
ATOM   1334 O O    . THR A 1 88  ? 20.39800 6.82300   -4.97500  1.000 48.14000  ? 88  THR A O    1 
ATOM   1335 C CB   . THR A 1 88  ? 20.46000 7.64500   -8.30800  1.000 53.59000  ? 88  THR A CB   1 
ATOM   1336 O OG1  . THR A 1 88  ? 19.15400 7.97400   -7.80600  1.000 57.26000  ? 88  THR A OG1  1 
ATOM   1337 C CG2  . THR A 1 88  ? 20.36800 6.94200   -9.66200  1.000 62.49000  ? 88  THR A CG2  1 
ATOM   1338 H H    . THR A 1 88  ? 20.00300 5.30600   -7.87400  1.000 66.13000  ? 88  THR A H    1 
ATOM   1339 H HA   . THR A 1 88  ? 22.14300 6.77900   -7.52100  1.000 62.78000  ? 88  THR A HA   1 
ATOM   1340 H HB   . THR A 1 88  ? 20.94800 8.47200   -8.44800  1.000 64.18000  ? 88  THR A HB   1 
ATOM   1341 H HG1  . THR A 1 88  ? 19.21900 8.52300   -7.17400  1.000 68.59000  ? 88  THR A HG1  1 
ATOM   1342 H HG21 . THR A 1 88  ? 19.96400 7.53300   -10.31600 1.000 74.86000  ? 88  THR A HG21 1 
ATOM   1343 H HG22 . THR A 1 88  ? 21.25500 6.69300   -9.96800  1.000 74.86000  ? 88  THR A HG22 1 
ATOM   1344 H HG23 . THR A 1 88  ? 19.82700 6.14100   -9.58400  1.000 74.86000  ? 88  THR A HG23 1 
ATOM   1345 N N    . LYS A 1 89  ? 21.82700 8.44900   -5.60200  1.000 39.78000  ? 89  LYS A N    1 
ATOM   1346 C CA   . LYS A 1 89  ? 21.59200 9.11100   -4.32000  1.000 50.84000  ? 89  LYS A CA   1 
ATOM   1347 C C    . LYS A 1 89  ? 20.10500 9.44500   -4.07900  1.000 50.58000  ? 89  LYS A C    1 
ATOM   1348 O O    . LYS A 1 89  ? 19.65500 9.40400   -2.92900  1.000 53.91000  ? 89  LYS A O    1 
ATOM   1349 C CB   . LYS A 1 89  ? 22.42200 10.38900  -4.18200  1.000 58.72000  ? 89  LYS A CB   1 
ATOM   1350 C CG   . LYS A 1 89  ? 22.04300 11.29600  -2.91500  1.000 61.13000  ? 89  LYS A CG   1 
ATOM   1351 C CD   . LYS A 1 89  ? 23.14400 12.23300  -2.38600  1.000 65.38000  ? 89  LYS A CD   1 
ATOM   1352 C CE   . LYS A 1 89  ? 22.67600 13.70100  -2.25400  1.000 69.33000  ? 89  LYS A CE   1 
ATOM   1353 N NZ   . LYS A 1 89  ? 23.76900 14.65100  -1.86800  1.000 91.29000  ? 89  LYS A NZ   1 
ATOM   1354 H H    . LYS A 1 89  ? 22.42000 8.80000   -6.11600  1.000 47.62000  ? 89  LYS A H    1 
ATOM   1355 H HA   . LYS A 1 89  ? 21.88000 8.48600   -3.63700  1.000 60.89000  ? 89  LYS A HA   1 
ATOM   1356 H HB2  . LYS A 1 89  ? 23.35700 10.14300  -4.09700  1.000 70.34000  ? 89  LYS A HB2  1 
ATOM   1357 H HB3  . LYS A 1 89  ? 22.29300 10.92900  -4.97800  1.000 70.34000  ? 89  LYS A HB3  1 
ATOM   1358 H HG2  . LYS A 1 89  ? 21.28800 11.85400  -3.15900  1.000 73.23000  ? 89  LYS A HG2  1 
ATOM   1359 H HG3  . LYS A 1 89  ? 21.79800 10.70700  -2.18500  1.000 73.23000  ? 89  LYS A HG3  1 
ATOM   1360 H HD2  . LYS A 1 89  ? 23.42300 11.92900  -1.50900  1.000 78.33000  ? 89  LYS A HD2  1 
ATOM   1361 H HD3  . LYS A 1 89  ? 23.89600 12.21400  -2.99900  1.000 78.33000  ? 89  LYS A HD3  1 
ATOM   1362 H HE2  . LYS A 1 89  ? 22.31900 13.99300  -3.10800  1.000 83.08000  ? 89  LYS A HE2  1 
ATOM   1363 H HE3  . LYS A 1 89  ? 21.98800 13.74900  -1.57300  1.000 83.08000  ? 89  LYS A HE3  1 
ATOM   1364 H HZ1  . LYS A 1 89  ? 23.44900 15.48000  -1.82300  1.000 109.42000 ? 89  LYS A HZ1  1 
ATOM   1365 H HZ2  . LYS A 1 89  ? 24.10100 14.42600  -1.07400  1.000 109.42000 ? 89  LYS A HZ2  1 
ATOM   1366 H HZ3  . LYS A 1 89  ? 24.42200 14.62600  -2.47200  1.000 109.42000 ? 89  LYS A HZ3  1 
ATOM   1367 N N    . ALA A 1 90  ? 19.34400 9.82500   -5.11500  1.000 53.14000  ? 90  ALA A N    1 
ATOM   1368 C CA   . ALA A 1 90  ? 17.93800 10.19000  -4.90300  1.000 48.00000  ? 90  ALA A CA   1 
ATOM   1369 C C    . ALA A 1 90  ? 17.12300 8.95300   -4.54500  1.000 57.68000  ? 90  ALA A C    1 
ATOM   1370 O O    . ALA A 1 90  ? 16.29900 8.99300   -3.63800  1.000 53.32000  ? 90  ALA A O    1 
ATOM   1371 C CB   . ALA A 1 90  ? 17.37100 10.88500  -6.14200  1.000 44.88000  ? 90  ALA A CB   1 
ATOM   1372 H H    . ALA A 1 90  ? 19.61100 9.87800   -5.93100  1.000 63.65000  ? 90  ALA A H    1 
ATOM   1373 H HA   . ALA A 1 90  ? 17.87600 10.82400  -4.17100  1.000 57.47000  ? 90  ALA A HA   1 
ATOM   1374 H HB1  . ALA A 1 90  ? 16.50300 11.25900  -5.92400  1.000 53.74000  ? 90  ALA A HB1  1 
ATOM   1375 H HB2  . ALA A 1 90  ? 17.97700 11.59200  -6.41200  1.000 53.74000  ? 90  ALA A HB2  1 
ATOM   1376 H HB3  . ALA A 1 90  ? 17.28200 10.23500  -6.85600  1.000 53.74000  ? 90  ALA A HB3  1 
ATOM   1377 N N    . ASP A 1 91  ? 17.35400 7.84000   -5.24000  1.000 40.66000  ? 91  ASP A N    1 
ATOM   1378 C CA   . ASP A 1 91  ? 16.78900 6.56700   -4.83500  1.000 56.22000  ? 91  ASP A CA   1 
ATOM   1379 C C    . ASP A 1 91  ? 16.95400 6.34700   -3.32100  1.000 61.09000  ? 91  ASP A C    1 
ATOM   1380 O O    . ASP A 1 91  ? 15.98300 6.08100   -2.60000  1.000 63.33000  ? 91  ASP A O    1 
ATOM   1381 C CB   . ASP A 1 91  ? 17.45000 5.44300   -5.66700  1.000 54.96000  ? 91  ASP A CB   1 
ATOM   1382 C CG   . ASP A 1 91  ? 17.01100 5.43600   -7.13500  1.000 57.33000  ? 91  ASP A CG   1 
ATOM   1383 O OD1  . ASP A 1 91  ? 15.80100 5.52100   -7.40200  1.000 77.42000  ? 91  ASP A OD1  1 
ATOM   1384 O OD2  . ASP A 1 91  ? 17.83600 5.28600   -8.04000  1.000 57.11000  ? 91  ASP A OD2  1 
ATOM   1385 H H    . ASP A 1 91  ? 17.83600 7.80000   -5.95100  1.000 48.66000  ? 91  ASP A H    1 
ATOM   1386 H HA   . ASP A 1 91  ? 15.83600 6.54600   -5.01700  1.000 67.34000  ? 91  ASP A HA   1 
ATOM   1387 H HB2  . ASP A 1 91  ? 18.41300 5.56200   -5.64500  1.000 65.83000  ? 91  ASP A HB2  1 
ATOM   1388 H HB3  . ASP A 1 91  ? 17.21300 4.58600   -5.28100  1.000 65.83000  ? 91  ASP A HB3  1 
ATOM   1389 N N    . LEU A 1 92  ? 18.17500 6.48600   -2.80900  1.000 62.95000  ? 92  LEU A N    1 
ATOM   1390 C CA   . LEU A 1 92  ? 18.40600 6.08900   -1.41800  1.000 65.73000  ? 92  LEU A CA   1 
ATOM   1391 C C    . LEU A 1 92  ? 17.67700 6.99800   -0.43600  1.000 55.59000  ? 92  LEU A C    1 
ATOM   1392 O O    . LEU A 1 92  ? 17.26800 6.55300   0.64900   1.000 62.43000  ? 92  LEU A O    1 
ATOM   1393 C CB   . LEU A 1 92  ? 19.90800 6.07900   -1.09800  1.000 51.90000  ? 92  LEU A CB   1 
ATOM   1394 C CG   . LEU A 1 92  ? 20.71700 4.95100   -1.72600  1.000 49.82000  ? 92  LEU A CG   1 
ATOM   1395 C CD1  . LEU A 1 92  ? 22.17500 5.36100   -1.77900  1.000 63.00000  ? 92  LEU A CD1  1 
ATOM   1396 C CD2  . LEU A 1 92  ? 20.52000 3.72900   -0.88100  1.000 53.65000  ? 92  LEU A CD2  1 
ATOM   1397 H H    . LEU A 1 92  ? 18.86000 6.79500   -3.22600  1.000 75.42000  ? 92  LEU A H    1 
ATOM   1398 H HA   . LEU A 1 92  ? 18.06900 5.18600   -1.30700  1.000 78.76000  ? 92  LEU A HA   1 
ATOM   1399 H HB2  . LEU A 1 92  ? 20.29000 6.91500   -1.40900  1.000 62.16000  ? 92  LEU A HB2  1 
ATOM   1400 H HB3  . LEU A 1 92  ? 20.01200 6.00500   -0.13600  1.000 62.16000  ? 92  LEU A HB3  1 
ATOM   1401 H HG   . LEU A 1 92  ? 20.43500 4.75700   -2.63400  1.000 59.66000  ? 92  LEU A HG   1 
ATOM   1402 H HD11 . LEU A 1 92  ? 22.69600 4.62600   -2.13800  1.000 75.48000  ? 92  LEU A HD11 1 
ATOM   1403 H HD12 . LEU A 1 92  ? 22.26300 6.14000   -2.35000  1.000 75.48000  ? 92  LEU A HD12 1 
ATOM   1404 H HD13 . LEU A 1 92  ? 22.47600 5.57300   -0.88200  1.000 75.48000  ? 92  LEU A HD13 1 
ATOM   1405 H HD21 . LEU A 1 92  ? 20.90500 2.96500   -1.33600  1.000 64.26000  ? 92  LEU A HD21 1 
ATOM   1406 H HD22 . LEU A 1 92  ? 20.96100 3.86200   -0.02700  1.000 64.26000  ? 92  LEU A HD22 1 
ATOM   1407 H HD23 . LEU A 1 92  ? 19.57000 3.58900   -0.74400  1.000 64.26000  ? 92  LEU A HD23 1 
ATOM   1408 N N    . VAL A 1 93  ? 17.54000 8.28100   -0.78700  1.000 59.04000  ? 93  VAL A N    1 
ATOM   1409 C CA   . VAL A 1 93  ? 16.88700 9.25000   0.08600   1.000 77.12000  ? 93  VAL A CA   1 
ATOM   1410 C C    . VAL A 1 93  ? 15.37300 9.14300   0.02700   1.000 80.25000  ? 93  VAL A C    1 
ATOM   1411 O O    . VAL A 1 93  ? 14.69500 9.83800   0.78900   1.000 102.33000 ? 93  VAL A O    1 
ATOM   1412 C CB   . VAL A 1 93  ? 17.34600 10.68300  -0.27000  1.000 68.62000  ? 93  VAL A CB   1 
ATOM   1413 C CG1  . VAL A 1 93  ? 16.74500 11.68300  0.67700   1.000 85.21000  ? 93  VAL A CG1  1 
ATOM   1414 C CG2  . VAL A 1 93  ? 18.86700 10.79900  -0.19400  1.000 70.78000  ? 93  VAL A CG2  1 
ATOM   1415 H H    . VAL A 1 93  ? 17.82000 8.61300   -1.52900  1.000 70.72000  ? 93  VAL A H    1 
ATOM   1416 H HA   . VAL A 1 93  ? 17.14700 9.07600   1.00400   1.000 92.42000  ? 93  VAL A HA   1 
ATOM   1417 H HB   . VAL A 1 93  ? 17.05000 10.87400  -1.17400  1.000 82.22000  ? 93  VAL A HB   1 
ATOM   1418 H HG11 . VAL A 1 93  ? 16.47400 11.22600  1.48900   1.000 102.12000 ? 93  VAL A HG11 1 
ATOM   1419 H HG12 . VAL A 1 93  ? 17.40700 12.36100  0.88300   1.000 102.12000 ? 93  VAL A HG12 1 
ATOM   1420 H HG13 . VAL A 1 93  ? 15.97300 12.09300  0.25500   1.000 102.12000 ? 93  VAL A HG13 1 
ATOM   1421 H HG21 . VAL A 1 93  ? 19.14300 11.61900  -0.63200  1.000 84.81000  ? 93  VAL A HG21 1 
ATOM   1422 H HG22 . VAL A 1 93  ? 19.13600 10.81600  0.73800   1.000 84.81000  ? 93  VAL A HG22 1 
ATOM   1423 H HG23 . VAL A 1 93  ? 19.26400 10.03500  -0.64000  1.000 84.81000  ? 93  VAL A HG23 1 
ATOM   1424 N N    . ASN A 1 94  ? 14.81300 8.26900   -0.82100  1.000 77.03000  ? 94  ASN A N    1 
ATOM   1425 C CA   . ASN A 1 94  ? 13.36700 8.27300   -1.05000  1.000 88.45000  ? 94  ASN A CA   1 
ATOM   1426 C C    . ASN A 1 94  ? 12.88000 6.90600   -1.51900  1.000 98.49000  ? 94  ASN A C    1 
ATOM   1427 O O    . ASN A 1 94  ? 12.08900 6.80300   -2.46600  1.000 90.68000  ? 94  ASN A O    1 
ATOM   1428 C CB   . ASN A 1 94  ? 13.08600 9.44500   -2.02000  1.000 81.04000  ? 94  ASN A CB   1 
ATOM   1429 C CG   . ASN A 1 94  ? 11.82900 9.30000   -2.79800  1.000 102.67000 ? 94  ASN A CG   1 
ATOM   1430 O OD1  . ASN A 1 94  ? 11.75400 8.50000   -3.72700  1.000 93.39000  ? 94  ASN A OD1  1 
ATOM   1431 N ND2  . ASN A 1 94  ? 10.80900 10.06700  -2.42200  1.000 121.44000 ? 94  ASN A ND2  1 
ATOM   1432 H H    . ASN A 1 94  ? 15.24500 7.67400   -1.26700  1.000 92.31000  ? 94  ASN A H    1 
ATOM   1433 H HA   . ASN A 1 94  ? 12.84700 8.42200   -0.24500  1.000 106.01000 ? 94  ASN A HA   1 
ATOM   1434 H HB2  . ASN A 1 94  ? 13.02200 10.26500  -1.50600  1.000 97.12000  ? 94  ASN A HB2  1 
ATOM   1435 H HB3  . ASN A 1 94  ? 13.81800 9.50700   -2.65300  1.000 97.12000  ? 94  ASN A HB3  1 
ATOM   1436 H HD21 . ASN A 1 94  ? 10.90000 10.60900  -1.76000  1.000 145.60000 ? 94  ASN A HD21 1 
ATOM   1437 H HD22 . ASN A 1 94  ? 10.05900 10.02100  -2.84000  1.000 145.60000 ? 94  ASN A HD22 1 
ATOM   1438 N N    . ASN A 1 95  ? 13.31900 5.85300   -0.82700  1.000 81.63000  ? 95  ASN A N    1 
ATOM   1439 C CA   . ASN A 1 95  ? 12.99400 4.51900   -1.29200  1.000 100.58000 ? 95  ASN A CA   1 
ATOM   1440 C C    . ASN A 1 95  ? 11.84400 3.88800   -0.49900  1.000 95.75000  ? 95  ASN A C    1 
ATOM   1441 O O    . ASN A 1 95  ? 11.97300 3.66800   0.70700   1.000 90.61000  ? 95  ASN A O    1 
ATOM   1442 C CB   . ASN A 1 95  ? 14.25500 3.62300   -1.23400  1.000 109.91000 ? 95  ASN A CB   1 
ATOM   1443 C CG   . ASN A 1 95  ? 14.49000 2.81400   -2.53800  1.000 82.20000  ? 95  ASN A CG   1 
ATOM   1444 O OD1  . ASN A 1 95  ? 15.63200 2.51000   -2.87800  1.000 89.31000  ? 95  ASN A OD1  1 
ATOM   1445 N ND2  . ASN A 1 95  ? 13.40100 2.43700   -3.23900  1.000 96.99000  ? 95  ASN A ND2  1 
ATOM   1446 H H    . ASN A 1 95  ? 13.79000 5.89100   -0.10900  1.000 97.83000  ? 95  ASN A H    1 
ATOM   1447 H HA   . ASN A 1 95  ? 12.69400 4.57300   -2.21300  1.000 120.57000 ? 95  ASN A HA   1 
ATOM   1448 H HB2  . ASN A 1 95  ? 15.03300 4.18400   -1.08700  1.000 131.77000 ? 95  ASN A HB2  1 
ATOM   1449 H HB3  . ASN A 1 95  ? 14.15900 2.99100   -0.50400  1.000 131.77000 ? 95  ASN A HB3  1 
ATOM   1450 H HD21 . ASN A 1 95  ? 12.61600 2.64500   -2.95800  1.000 116.26000 ? 95  ASN A HD21 1 
ATOM   1451 H HD22 . ASN A 1 95  ? 13.49300 1.98700   -3.96600  1.000 116.26000 ? 95  ASN A HD22 1 
ATOM   1452 N N    . THR A 1 98  ? 9.16300  5.63700   -3.39100  1.000 93.09000  ? 98  THR A N    1 
ATOM   1453 C CA   . THR A 1 98  ? 8.71700  4.96300   -2.17500  1.000 98.42000  ? 98  THR A CA   1 
ATOM   1454 C C    . THR A 1 98  ? 7.49400  4.09100   -2.50000  1.000 110.88000 ? 98  THR A C    1 
ATOM   1455 O O    . THR A 1 98  ? 6.35500  4.49000   -2.16900  1.000 104.56000 ? 98  THR A O    1 
ATOM   1456 C CB   . THR A 1 98  ? 8.35000  5.96400   -1.01200  1.000 101.42000 ? 98  THR A CB   1 
ATOM   1457 O OG1  . THR A 1 98  ? 7.11700  6.64400   -1.28500  1.000 97.56000  ? 98  THR A OG1  1 
ATOM   1458 C CG2  . THR A 1 98  ? 9.45600  6.96900   -0.79200  1.000 104.36000 ? 98  THR A CG2  1 
ATOM   1459 H HA   . THR A 1 98  ? 9.43600  4.40700   -1.83600  1.000 117.98000 ? 98  THR A HA   1 
ATOM   1460 H HB   . THR A 1 98  ? 8.23800  5.45400   -0.19400  1.000 121.58000 ? 98  THR A HB   1 
ATOM   1461 H HG1  . THR A 1 98  ? 6.72700  6.28200   -1.93400  1.000 116.95000 ? 98  THR A HG1  1 
ATOM   1462 H HG21 . THR A 1 98  ? 9.14800  7.67900   -0.20800  1.000 125.11000 ? 98  THR A HG21 1 
ATOM   1463 H HG22 . THR A 1 98  ? 10.22200 6.53500   -0.38300  1.000 125.11000 ? 98  THR A HG22 1 
ATOM   1464 H HG23 . THR A 1 98  ? 9.72800  7.35400   -1.64000  1.000 125.11000 ? 98  THR A HG23 1 
ATOM   1465 N N    . ILE A 1 99  ? 7.71200  2.96300   -3.20300  1.000 96.03000  ? 99  ILE A N    1 
ATOM   1466 C CA   . ILE A 1 99  ? 6.68900  1.90900   -3.21100  1.000 93.19000  ? 99  ILE A CA   1 
ATOM   1467 C C    . ILE A 1 99  ? 6.60400  1.30900   -1.80100  1.000 90.60000  ? 99  ILE A C    1 
ATOM   1468 O O    . ILE A 1 99  ? 5.63600  0.60200   -1.45800  1.000 90.44000  ? 99  ILE A O    1 
ATOM   1469 C CB   . ILE A 1 99  ? 6.93600  0.78300   -4.24900  1.000 97.53000  ? 99  ILE A CB   1 
ATOM   1470 C CG1  . ILE A 1 99  ? 6.75400  1.31200   -5.67600  1.000 108.44000 ? 99  ILE A CG1  1 
ATOM   1471 C CG2  . ILE A 1 99  ? 6.01000  -0.43300  -3.96500  1.000 73.10000  ? 99  ILE A CG2  1 
ATOM   1472 C CD1  . ILE A 1 99  ? 7.26400  0.34400   -6.78700  1.000 89.50000  ? 99  ILE A CD1  1 
ATOM   1473 H H    . ILE A 1 99  ? 8.41800  2.79300   -3.66400  1.000 115.11000 ? 99  ILE A H    1 
ATOM   1474 H HA   . ILE A 1 99  ? 5.85300  2.31600   -3.48600  1.000 111.70000 ? 99  ILE A HA   1 
ATOM   1475 H HB   . ILE A 1 99  ? 7.85500  0.48300   -4.16300  1.000 116.91000 ? 99  ILE A HB   1 
ATOM   1476 H HG12 . ILE A 1 99  ? 5.80900  1.46600   -5.83100  1.000 130.01000 ? 99  ILE A HG12 1 
ATOM   1477 H HG13 . ILE A 1 99  ? 7.24500  2.14400   -5.76300  1.000 130.01000 ? 99  ILE A HG13 1 
ATOM   1478 H HG21 . ILE A 1 99  ? 5.95200  -0.97900  -4.76500  1.000 87.60000  ? 99  ILE A HG21 1 
ATOM   1479 H HG22 . ILE A 1 99  ? 6.38400  -0.95300  -3.23700  1.000 87.60000  ? 99  ILE A HG22 1 
ATOM   1480 H HG23 . ILE A 1 99  ? 5.12900  -0.10900  -3.72200  1.000 87.60000  ? 99  ILE A HG23 1 
ATOM   1481 H HD11 . ILE A 1 99  ? 7.42800  0.85100   -7.59700  1.000 107.28000 ? 99  ILE A HD11 1 
ATOM   1482 H HD12 . ILE A 1 99  ? 8.08500  -0.07700  -6.48700  1.000 107.28000 ? 99  ILE A HD12 1 
ATOM   1483 H HD13 . ILE A 1 99  ? 6.58800  -0.33200  -6.95200  1.000 107.28000 ? 99  ILE A HD13 1 
ATOM   1484 N N    . ALA A 1 100 ? 7.64700  1.55500   -0.98900  1.000 82.74000  ? 100 ALA A N    1 
ATOM   1485 C CA   . ALA A 1 100 ? 7.72000  1.02600   0.37100   1.000 75.43000  ? 100 ALA A CA   1 
ATOM   1486 C C    . ALA A 1 100 ? 6.48900  1.41200   1.17100   1.000 74.35000  ? 100 ALA A C    1 
ATOM   1487 O O    . ALA A 1 100 ? 5.90700  0.56900   1.86200   1.000 71.34000  ? 100 ALA A O    1 
ATOM   1488 C CB   . ALA A 1 100 ? 8.99200  1.52300   1.06800   1.000 67.92000  ? 100 ALA A CB   1 
ATOM   1489 H H    . ALA A 1 100 ? 8.32900  2.03100   -1.20800  1.000 99.16000  ? 100 ALA A H    1 
ATOM   1490 H HA   . ALA A 1 100 ? 7.76400  0.05800   0.32700   1.000 90.39000  ? 100 ALA A HA   1 
ATOM   1491 H HB1  . ALA A 1 100 ? 9.76600  1.21000   0.57400   1.000 81.38000  ? 100 ALA A HB1  1 
ATOM   1492 H HB2  . ALA A 1 100 ? 8.98300  2.49300   1.08800   1.000 81.38000  ? 100 ALA A HB2  1 
ATOM   1493 H HB3  . ALA A 1 100 ? 9.01400  1.17400   1.97300   1.000 81.38000  ? 100 ALA A HB3  1 
ATOM   1494 N N    . LYS A 1 101 ? 6.05600  2.67600   1.05000   1.000 73.47000  ? 101 LYS A N    1 
ATOM   1495 C CA   . LYS A 1 101 ? 4.88900  3.17600   1.78400   1.000 87.29000  ? 101 LYS A CA   1 
ATOM   1496 C C    . LYS A 1 101 ? 3.68100  2.23800   1.67400   1.000 64.35000  ? 101 LYS A C    1 
ATOM   1497 O O    . LYS A 1 101 ? 3.09100  1.86100   2.69000   1.000 72.53000  ? 101 LYS A O    1 
ATOM   1498 C CB   . LYS A 1 101 ? 4.50800  4.56900   1.28100   1.000 30.00000  ? 101 LYS A CB   1 
ATOM   1499 H H    . LYS A 1 101 ? 6.41600  3.27500   0.54900   1.000 73.47000  ? 101 LYS A H    1 
ATOM   1500 H HA   . LYS A 1 101 ? 5.13900  3.21900   2.72000   1.000 87.29000  ? 101 LYS A HA   1 
ATOM   1501 N N    . SER A 1 102 ? 3.29000  1.85700   0.45200   1.000 76.22000  ? 102 SER A N    1 
ATOM   1502 C CA   . SER A 1 102 ? 2.08600  1.04200   0.28300   1.000 74.97000  ? 102 SER A CA   1 
ATOM   1503 C C    . SER A 1 102 ? 2.29700  -0.37400  0.79200   1.000 70.93000  ? 102 SER A C    1 
ATOM   1504 O O    . SER A 1 102 ? 1.41800  -0.94300  1.44500   1.000 66.74000  ? 102 SER A O    1 
ATOM   1505 C CB   . SER A 1 102 ? 1.67500  0.97200   -1.18700  1.000 84.27000  ? 102 SER A CB   1 
ATOM   1506 O OG   . SER A 1 102 ? 1.94100  2.18600   -1.85800  1.000 109.88000 ? 102 SER A OG   1 
ATOM   1507 H H    . SER A 1 102 ? 3.69700  2.05500   -0.28000  1.000 91.34000  ? 102 SER A H    1 
ATOM   1508 H HA   . SER A 1 102 ? 1.37600  1.46700   0.78900   1.000 89.84000  ? 102 SER A HA   1 
ATOM   1509 H HB2  . SER A 1 102 ? 2.17300  0.26000   -1.61800  1.000 101.00000 ? 102 SER A HB2  1 
ATOM   1510 H HB3  . SER A 1 102 ? 0.72300  0.78900   -1.23700  1.000 101.00000 ? 102 SER A HB3  1 
ATOM   1511 H HG   . SER A 1 102 ? 1.70800  2.12600   -2.66300  1.000 131.74000 ? 102 SER A HG   1 
ATOM   1512 N N    . GLY A 1 103 ? 3.45200  -0.96500  0.53700   1.000 75.97000  ? 103 GLY A N    1 
ATOM   1513 C CA   . GLY A 1 103 ? 3.68500  -2.36000  0.91800   1.000 58.57000  ? 103 GLY A CA   1 
ATOM   1514 C C    . GLY A 1 103 ? 3.89300  -2.48900  2.39000   1.000 60.20000  ? 103 GLY A C    1 
ATOM   1515 O O    . GLY A 1 103 ? 3.77900  -3.59300  2.88100   1.000 61.71000  ? 103 GLY A O    1 
ATOM   1516 H H    . GLY A 1 103 ? 4.14600  -0.53400  0.13700   1.000 91.04000  ? 103 GLY A H    1 
ATOM   1517 H HA2  . GLY A 1 103 ? 2.92100  -2.91600  0.63600   1.000 70.16000  ? 103 GLY A HA2  1 
ATOM   1518 H HA3  . GLY A 1 103 ? 4.48400  -2.68000  0.45300   1.000 70.16000  ? 103 GLY A HA3  1 
ATOM   1519 N N    . THR A 1 104 ? 4.28200  -1.41600  3.05200   1.000 66.55000  ? 104 THR A N    1 
ATOM   1520 C CA   . THR A 1 104 ? 4.56300  -1.41400  4.48800   1.000 67.88000  ? 104 THR A CA   1 
ATOM   1521 C C    . THR A 1 104 ? 3.24400  -1.42300  5.17300   1.000 45.87000  ? 104 THR A C    1 
ATOM   1522 O O    . THR A 1 104 ? 3.11600  -2.14900  6.10600   1.000 75.02000  ? 104 THR A O    1 
ATOM   1523 C CB   . THR A 1 104 ? 5.41400  -0.20600  4.85900   1.000 60.01000  ? 104 THR A CB   1 
ATOM   1524 O OG1  . THR A 1 104 ? 6.69000  -0.57300  4.35500   1.000 62.47000  ? 104 THR A OG1  1 
ATOM   1525 C CG2  . THR A 1 104 ? 5.48500  0.04200   6.35200   1.000 69.09000  ? 104 THR A CG2  1 
ATOM   1526 H H    . THR A 1 104 ? 4.40500  -0.60700  2.67200   1.000 79.74000  ? 104 THR A H    1 
ATOM   1527 H HA   . THR A 1 104 ? 5.05500  -2.23100  4.71900   1.000 81.33000  ? 104 THR A HA   1 
ATOM   1528 H HB   . THR A 1 104 ? 5.08700  0.60200   4.39700   1.000 71.89000  ? 104 THR A HB   1 
ATOM   1529 H HG1  . THR A 1 104 ? 7.22800  -0.70500  5.01600   1.000 74.84000  ? 104 THR A HG1  1 
ATOM   1530 H HG21 . THR A 1 104 ? 5.57900  -0.80600  6.81900   1.000 82.78000  ? 104 THR A HG21 1 
ATOM   1531 H HG22 . THR A 1 104 ? 6.25100  0.60500   6.55000   1.000 82.78000  ? 104 THR A HG22 1 
ATOM   1532 H HG23 . THR A 1 104 ? 4.67300  0.48700   6.64900   1.000 82.78000  ? 104 THR A HG23 1 
ATOM   1533 N N    . LYS A 1 105 ? 2.28400  -0.67800  4.66500   1.000 63.65000  ? 105 LYS A N    1 
ATOM   1534 C CA   . LYS A 1 105 ? 0.93900  -0.60900  5.27900   1.000 72.61000  ? 105 LYS A CA   1 
ATOM   1535 C C    . LYS A 1 105 ? 0.24300  -1.95200  5.07000   1.000 51.86000  ? 105 LYS A C    1 
ATOM   1536 O O    . LYS A 1 105 ? -0.10000 -2.49900  6.05000   1.000 56.87000  ? 105 LYS A O    1 
ATOM   1537 C CB   . LYS A 1 105 ? 0.18500  0.58900   4.70100   1.000 58.27000  ? 105 LYS A CB   1 
ATOM   1538 C CG   . LYS A 1 105 ? 0.66700  1.90600   5.27000   1.000 93.35000  ? 105 LYS A CG   1 
ATOM   1539 C CD   . LYS A 1 105 ? -0.25700 3.08000   4.98800   1.000 116.09000 ? 105 LYS A CD   1 
ATOM   1540 C CE   . LYS A 1 105 ? 0.50700  4.30200   4.61800   1.000 109.98000 ? 105 LYS A CE   1 
ATOM   1541 N NZ   . LYS A 1 105 ? 0.66800  4.38100   3.16700   1.000 90.16000  ? 105 LYS A NZ   1 
ATOM   1542 H H    . LYS A 1 105 ? 2.41300  -0.18400  3.92100   1.000 76.25000  ? 105 LYS A H    1 
ATOM   1543 H HA   . LYS A 1 105 ? 1.05000  -0.46300  6.25100   1.000 87.01000  ? 105 LYS A HA   1 
ATOM   1544 H HB2  . LYS A 1 105 ? 0.30400  0.60300   3.72800   1.000 69.80000  ? 105 LYS A HB2  1 
ATOM   1545 H HB3  . LYS A 1 105 ? -0.77100 0.49200   4.89100   1.000 69.80000  ? 105 LYS A HB3  1 
ATOM   1546 H HG2  . LYS A 1 105 ? 0.77100  1.80600   6.24000   1.000 111.90000 ? 105 LYS A HG2  1 
ATOM   1547 H HG3  . LYS A 1 105 ? 1.55200  2.10000   4.89400   1.000 111.90000 ? 105 LYS A HG3  1 
ATOM   1548 H HD2  . LYS A 1 105 ? -0.85900 2.84300   4.25100   1.000 139.18000 ? 105 LYS A HD2  1 
ATOM   1549 H HD3  . LYS A 1 105 ? -0.79800 3.26500   5.78500   1.000 139.18000 ? 105 LYS A HD3  1 
ATOM   1550 H HE2  . LYS A 1 105 ? 0.04600  5.09700   4.93700   1.000 131.85000 ? 105 LYS A HE2  1 
ATOM   1551 H HE3  . LYS A 1 105 ? 1.38700  4.26700   5.03200   1.000 131.85000 ? 105 LYS A HE3  1 
ATOM   1552 H HZ1  . LYS A 1 105 ? 1.21000  5.07500   2.95600   1.000 108.07000 ? 105 LYS A HZ1  1 
ATOM   1553 H HZ2  . LYS A 1 105 ? 1.03700  3.61100   2.86300   1.000 108.07000 ? 105 LYS A HZ2  1 
ATOM   1554 H HZ3  . LYS A 1 105 ? -0.14100 4.49900   2.77900   1.000 108.07000 ? 105 LYS A HZ3  1 
ATOM   1555 N N    . SER A 1 106 ? 0.10000  -2.44200  3.85000   1.000 52.63000  ? 106 SER A N    1 
ATOM   1556 C CA   . SER A 1 106 ? -0.53100 -3.71200  3.50300   1.000 34.06000  ? 106 SER A CA   1 
ATOM   1557 C C    . SER A 1 106 ? 0.05400  -4.85000  4.32100   1.000 55.38000  ? 106 SER A C    1 
ATOM   1558 O O    . SER A 1 106 ? -0.68900 -5.62400  4.94200   1.000 51.85000  ? 106 SER A O    1 
ATOM   1559 C CB   . SER A 1 106 ? -0.40500 -3.97300  1.99200   1.000 55.66000  ? 106 SER A CB   1 
ATOM   1560 O OG   . SER A 1 106 ? -1.10300 -3.00400  1.23900   1.000 58.88000  ? 106 SER A OG   1 
ATOM   1561 H H    . SER A 1 106 ? 0.41000  -2.01700  3.16900   1.000 63.03000  ? 106 SER A H    1 
ATOM   1562 H HA   . SER A 1 106 ? -1.47800 -3.66300  3.70600   1.000 40.75000  ? 106 SER A HA   1 
ATOM   1563 H HB2  . SER A 1 106 ? 0.53300  -3.94300  1.74600   1.000 66.67000  ? 106 SER A HB2  1 
ATOM   1564 H HB3  . SER A 1 106 ? -0.77200 -4.84800  1.79300   1.000 66.67000  ? 106 SER A HB3  1 
ATOM   1565 H HG   . SER A 1 106 ? -0.79400 -2.23900  1.39700   1.000 70.53000  ? 106 SER A HG   1 
ATOM   1566 N N    . PHE A 1 107 ? 1.39700  -4.95000  4.34500   1.000 64.54000  ? 107 PHE A N    1 
ATOM   1567 C CA   . PHE A 1 107 ? 2.06100  -5.99300  5.12100   1.000 63.97000  ? 107 PHE A CA   1 
ATOM   1568 C C    . PHE A 1 107 ? 1.73200  -5.87400  6.60800   1.000 43.79000  ? 107 PHE A C    1 
ATOM   1569 O O    . PHE A 1 107 ? 1.60000  -6.87800  7.31200   1.000 49.63000  ? 107 PHE A O    1 
ATOM   1570 C CB   . PHE A 1 107 ? 3.57900  -5.93500  4.90600   1.000 60.75000  ? 107 PHE A CB   1 
ATOM   1571 C CG   . PHE A 1 107 ? 4.34500  -6.89000  5.77900   1.000 52.27000  ? 107 PHE A CG   1 
ATOM   1572 C CD1  . PHE A 1 107 ? 4.14300  -8.24100  5.68100   1.000 72.01000  ? 107 PHE A CD1  1 
ATOM   1573 C CD2  . PHE A 1 107 ? 5.22400  -6.42900  6.72200   1.000 48.99000  ? 107 PHE A CD2  1 
ATOM   1574 C CE1  . PHE A 1 107 ? 4.81300  -9.11700  6.50100   1.000 49.65000  ? 107 PHE A CE1  1 
ATOM   1575 C CE2  . PHE A 1 107 ? 5.93300  -7.30600  7.52200   1.000 52.98000  ? 107 PHE A CE2  1 
ATOM   1576 C CZ   . PHE A 1 107 ? 5.71600  -8.64700  7.41700   1.000 63.32000  ? 107 PHE A CZ   1 
ATOM   1577 H H    . PHE A 1 107 ? 1.93400  -4.42800  3.92300   1.000 77.32000  ? 107 PHE A H    1 
ATOM   1578 H HA   . PHE A 1 107 ? 1.74700  -6.85500  4.80800   1.000 76.64000  ? 107 PHE A HA   1 
ATOM   1579 H HB2  . PHE A 1 107 ? 3.77200  -6.15700  3.98200   1.000 72.78000  ? 107 PHE A HB2  1 
ATOM   1580 H HB3  . PHE A 1 107 ? 3.88900  -5.03800  5.10300   1.000 72.78000  ? 107 PHE A HB3  1 
ATOM   1581 H HD1  . PHE A 1 107 ? 3.54500  -8.57000  5.05000   1.000 86.28000  ? 107 PHE A HD1  1 
ATOM   1582 H HD2  . PHE A 1 107 ? 5.34700  -5.51300  6.82600   1.000 58.66000  ? 107 PHE A HD2  1 
ATOM   1583 H HE1  . PHE A 1 107 ? 4.65300  -10.03100 6.43300   1.000 59.45000  ? 107 PHE A HE1  1 
ATOM   1584 H HE2  . PHE A 1 107 ? 6.55600  -6.98200  8.13100   1.000 63.46000  ? 107 PHE A HE2  1 
ATOM   1585 H HZ   . PHE A 1 107 ? 6.17900  -9.24000  7.96500   1.000 75.86000  ? 107 PHE A HZ   1 
ATOM   1586 N N    . MET A 1 108 ? 1.61900  -4.65900  7.11800   1.000 47.70000  ? 108 MET A N    1 
ATOM   1587 C CA   . MET A 1 108 ? 1.24500  -4.53300  8.51800   1.000 66.76000  ? 108 MET A CA   1 
ATOM   1588 C C    . MET A 1 108 ? -0.17400 -5.04700  8.74200   1.000 71.51000  ? 108 MET A C    1 
ATOM   1589 O O    . MET A 1 108 ? -0.40500 -5.80100  9.69400   1.000 57.26000  ? 108 MET A O    1 
ATOM   1590 C CB   . MET A 1 108 ? 1.42500  -3.08700  8.98700   1.000 61.12000  ? 108 MET A CB   1 
ATOM   1591 C CG   . MET A 1 108 ? 2.92400  -2.79700  9.16600   1.000 69.07000  ? 108 MET A CG   1 
ATOM   1592 S SD   . MET A 1 108 ? 3.46500  -1.86000  10.57700  1.000 77.63000  ? 108 MET A SD   1 
ATOM   1593 C CE   . MET A 1 108 ? 3.68600  -0.24500  9.80500   1.000 64.58000  ? 108 MET A CE   1 
ATOM   1594 H H    . MET A 1 108 ? 1.74800  -3.92100  6.69600   1.000 57.11000  ? 108 MET A H    1 
ATOM   1595 H HA   . MET A 1 108 ? 1.84500  -5.06600  9.06300   1.000 79.99000  ? 108 MET A HA   1 
ATOM   1596 H HB2  . MET A 1 108 ? 1.06300  -2.47900  8.32400   1.000 73.22000  ? 108 MET A HB2  1 
ATOM   1597 H HB3  . MET A 1 108 ? 0.97500  -2.95800  9.83700   1.000 73.22000  ? 108 MET A HB3  1 
ATOM   1598 H HG2  . MET A 1 108 ? 3.38100  -3.65100  9.21500   1.000 82.76000  ? 108 MET A HG2  1 
ATOM   1599 H HG3  . MET A 1 108 ? 3.22100  -2.30600  8.38400   1.000 82.76000  ? 108 MET A HG3  1 
ATOM   1600 H HE1  . MET A 1 108 ? 3.98800  0.38700   10.47600  1.000 77.38000  ? 108 MET A HE1  1 
ATOM   1601 H HE2  . MET A 1 108 ? 4.34700  -0.32100  9.10000   1.000 77.38000  ? 108 MET A HE2  1 
ATOM   1602 H HE3  . MET A 1 108 ? 2.83800  0.04600   9.43500   1.000 77.38000  ? 108 MET A HE3  1 
ATOM   1603 N N    . GLU A 1 109 ? -1.12900 -4.70000  7.85800   1.000 62.85000  ? 109 GLU A N    1 
ATOM   1604 C CA   . GLU A 1 109 ? -2.47500 -5.26300  7.97400   1.000 50.63000  ? 109 GLU A CA   1 
ATOM   1605 C C    . GLU A 1 109 ? -2.44900 -6.79900  7.93600   1.000 64.55000  ? 109 GLU A C    1 
ATOM   1606 O O    . GLU A 1 109 ? -3.11500 -7.46900  8.73900   1.000 74.92000  ? 109 GLU A O    1 
ATOM   1607 C CB   . GLU A 1 109 ? -3.37800 -4.72300  6.87100   1.000 63.34000  ? 109 GLU A CB   1 
ATOM   1608 C CG   . GLU A 1 109 ? -3.17700 -3.25700  6.52900   1.000 70.84000  ? 109 GLU A CG   1 
ATOM   1609 C CD   . GLU A 1 109 ? -4.06500 -2.34200  7.34000   1.000 87.78000  ? 109 GLU A CD   1 
ATOM   1610 O OE1  . GLU A 1 109 ? -3.91700 -2.30600  8.58500   1.000 82.19000  ? 109 GLU A OE1  1 
ATOM   1611 O OE2  . GLU A 1 109 ? -4.91600 -1.67300  6.71700   1.000 96.41000  ? 109 GLU A OE2  1 
ATOM   1612 H H    . GLU A 1 109 ? -1.02000 -4.15500  7.20200   1.000 75.30000  ? 109 GLU A H    1 
ATOM   1613 H HA   . GLU A 1 109 ? -2.84600 -4.98800  8.82600   1.000 60.63000  ? 109 GLU A HA   1 
ATOM   1614 H HB2  . GLU A 1 109 ? -3.21300 -5.23400  6.06300   1.000 75.89000  ? 109 GLU A HB2  1 
ATOM   1615 H HB3  . GLU A 1 109 ? -4.30100 -4.83200  7.15000   1.000 75.89000  ? 109 GLU A HB3  1 
ATOM   1616 H HG2  . GLU A 1 109 ? -2.25500 -3.01500  6.70600   1.000 84.88000  ? 109 GLU A HG2  1 
ATOM   1617 H HG3  . GLU A 1 109 ? -3.38200 -3.12000  5.59100   1.000 84.88000  ? 109 GLU A HG3  1 
ATOM   1618 N N    . ALA A 1 110 ? -1.68300 -7.38100  7.02300   1.000 57.39000  ? 110 ALA A N    1 
ATOM   1619 C CA   . ALA A 1 110 ? -1.69700 -8.83000  6.94600   1.000 58.04000  ? 110 ALA A CA   1 
ATOM   1620 C C    . ALA A 1 110 ? -1.16000 -9.46700  8.22300   1.000 64.22000  ? 110 ALA A C    1 
ATOM   1621 O O    . ALA A 1 110 ? -1.59500 -10.57300 8.59000   1.000 67.14000  ? 110 ALA A O    1 
ATOM   1622 C CB   . ALA A 1 110 ? -0.90800 -9.30500  5.73200   1.000 62.27000  ? 110 ALA A CB   1 
ATOM   1623 H H    . ALA A 1 110 ? -1.17000 -6.97700  6.46300   1.000 68.75000  ? 110 ALA A H    1 
ATOM   1624 H HA   . ALA A 1 110 ? -2.61300 -9.12700  6.83100   1.000 69.53000  ? 110 ALA A HA   1 
ATOM   1625 H HB1  . ALA A 1 110 ? -0.96100 -10.27200 5.67900   1.000 74.60000  ? 110 ALA A HB1  1 
ATOM   1626 H HB2  . ALA A 1 110 ? -1.28900 -8.90800  4.93300   1.000 74.60000  ? 110 ALA A HB2  1 
ATOM   1627 H HB3  . ALA A 1 110 ? 0.01700  -9.02900  5.82900   1.000 74.60000  ? 110 ALA A HB3  1 
ATOM   1628 N N    . LEU A 1 111 ? -0.21900 -8.79400  8.90700   1.000 57.13000  ? 111 LEU A N    1 
ATOM   1629 C CA   . LEU A 1 111 ? 0.35100  -9.36500  10.13100  1.000 86.15000  ? 111 LEU A CA   1 
ATOM   1630 C C    . LEU A 1 111 ? -0.67300 -9.39800  11.26100  1.000 62.24000  ? 111 LEU A C    1 
ATOM   1631 O O    . LEU A 1 111 ? -0.72500 -10.36800 12.01800  1.000 65.69000  ? 111 LEU A O    1 
ATOM   1632 C CB   . LEU A 1 111 ? 1.61200  -8.60400  10.57700  1.000 65.85000  ? 111 LEU A CB   1 
ATOM   1633 C CG   . LEU A 1 111 ? 2.92800  -8.96600  9.88900   1.000 54.54000  ? 111 LEU A CG   1 
ATOM   1634 C CD1  . LEU A 1 111 ? 4.02700  -7.95900  10.35200  1.000 65.26000  ? 111 LEU A CD1  1 
ATOM   1635 C CD2  . LEU A 1 111 ? 3.43200  -10.39300 10.02300  1.000 63.51000  ? 111 LEU A CD2  1 
ATOM   1636 H H    . LEU A 1 111 ? 0.09800  -8.02500  8.68600   1.000 68.43000  ? 111 LEU A H    1 
ATOM   1637 H HA   . LEU A 1 111 ? 0.61900  -10.27500 9.93000   1.000 103.25000 ? 111 LEU A HA   1 
ATOM   1638 H HB2  . LEU A 1 111 ? 1.46200  -7.65900  10.41700  1.000 78.89000  ? 111 LEU A HB2  1 
ATOM   1639 H HB3  . LEU A 1 111 ? 1.73600  -8.76500  11.52500  1.000 78.89000  ? 111 LEU A HB3  1 
ATOM   1640 H HG   . LEU A 1 111 ? 2.73900  -8.90500  8.94000   1.000 65.32000  ? 111 LEU A HG   1 
ATOM   1641 H HD11 . LEU A 1 111 ? 4.89600  -8.29300  10.08000  1.000 78.19000  ? 111 LEU A HD11 1 
ATOM   1642 H HD12 . LEU A 1 111 ? 3.86000  -7.09800  9.93800   1.000 78.19000  ? 111 LEU A HD12 1 
ATOM   1643 H HD13 . LEU A 1 111 ? 3.99200  -7.87400  11.31700  1.000 78.19000  ? 111 LEU A HD13 1 
ATOM   1644 H HD21 . LEU A 1 111 ? 4.29300  -10.46600 9.58300   1.000 76.09000  ? 111 LEU A HD21 1 
ATOM   1645 H HD22 . LEU A 1 111 ? 3.52200  -10.60900 10.96400  1.000 76.09000  ? 111 LEU A HD22 1 
ATOM   1646 H HD23 . LEU A 1 111 ? 2.79500  -10.99400 9.60500   1.000 76.09000  ? 111 LEU A HD23 1 
ATOM   1647 N N    . SER A 1 112 ? -1.50600 -8.36300  11.37200  1.000 57.01000  ? 112 SER A N    1 
ATOM   1648 C CA   . SER A 1 112 ? -2.64000 -8.38700  12.30300  1.000 75.50000  ? 112 SER A CA   1 
ATOM   1649 C C    . SER A 1 112 ? -3.51300 -9.62200  12.12000  1.000 79.24000  ? 112 SER A C    1 
ATOM   1650 O O    . SER A 1 112 ? -3.88600 -10.30000 13.09500  1.000 86.73000  ? 112 SER A O    1 
ATOM   1651 C CB   . SER A 1 112 ? -3.49300 -7.13200  12.10800  1.000 60.62000  ? 112 SER A CB   1 
ATOM   1652 O OG   . SER A 1 112 ? -2.68300 -5.98900  12.25600  1.000 97.86000  ? 112 SER A OG   1 
ATOM   1653 H H    . SER A 1 112 ? -1.44000 -7.63400  10.92100  1.000 68.29000  ? 112 SER A H    1 
ATOM   1654 H HA   . SER A 1 112 ? -2.28200 -8.40100  13.20400  1.000 90.48000  ? 112 SER A HA   1 
ATOM   1655 H HB2  . SER A 1 112 ? -3.87800 -7.13900  11.21700  1.000 72.62000  ? 112 SER A HB2  1 
ATOM   1656 H HB3  . SER A 1 112 ? -4.19800 -7.11500  12.77300  1.000 72.62000  ? 112 SER A HB3  1 
ATOM   1657 H HG   . SER A 1 112 ? -3.14500 -5.29500  12.15700  1.000 117.31000 ? 112 SER A HG   1 
ATOM   1658 N N    . ALA A 1 113 ? -3.87800 -9.90600  10.86800  1.000 65.82000  ? 113 ALA A N    1 
ATOM   1659 C CA   . ALA A 1 113 ? -4.67900 -11.08400 10.54400  1.000 61.39000  ? 113 ALA A CA   1 
ATOM   1660 C C    . ALA A 1 113 ? -3.97100 -12.41800 10.76000  1.000 66.49000  ? 113 ALA A C    1 
ATOM   1661 O O    . ALA A 1 113 ? -4.55200 -13.49300 10.52300  1.000 63.09000  ? 113 ALA A O    1 
ATOM   1662 C CB   . ALA A 1 113 ? -5.15000 -11.05300 9.08100   1.000 50.64000  ? 113 ALA A CB   1 
ATOM   1663 H H    . ALA A 1 113 ? -3.67300 -9.42700  10.18400  1.000 78.87000  ? 113 ALA A H    1 
ATOM   1664 H HA   . ALA A 1 113 ? -5.43000 -11.04400 11.15800  1.000 73.55000  ? 113 ALA A HA   1 
ATOM   1665 H HB1  . ALA A 1 113 ? -5.71300 -11.82600 8.91300   1.000 60.65000  ? 113 ALA A HB1  1 
ATOM   1666 H HB2  . ALA A 1 113 ? -5.65400 -10.23800 8.92800   1.000 60.65000  ? 113 ALA A HB2  1 
ATOM   1667 H HB3  . ALA A 1 113 ? -4.37500 -11.07600 8.49900   1.000 60.65000  ? 113 ALA A HB3  1 
ATOM   1668 N N    . GLY A 1 114 ? -2.70500 -12.36700 11.15500  1.000 60.99000  ? 114 GLY A N    1 
ATOM   1669 C CA   . GLY A 1 114 ? -1.93800 -13.58400 11.42300  1.000 57.77000  ? 114 GLY A CA   1 
ATOM   1670 C C    . GLY A 1 114 ? -1.01900 -14.07100 10.31100  1.000 68.10000  ? 114 GLY A C    1 
ATOM   1671 O O    . GLY A 1 114 ? -0.63300 -15.26600 10.29800  1.000 58.20000  ? 114 GLY A O    1 
ATOM   1672 H H    . GLY A 1 114 ? -2.26400 -11.63900 11.27700  1.000 73.07000  ? 114 GLY A H    1 
ATOM   1673 H HA2  . GLY A 1 114 ? -1.38600 -13.42800 12.20500  1.000 69.20000  ? 114 GLY A HA2  1 
ATOM   1674 H HA3  . GLY A 1 114 ? -2.56300 -14.30000 11.61400  1.000 69.20000  ? 114 GLY A HA3  1 
ATOM   1675 N N    . ALA A 1 115 ? -0.64200 -13.19100 9.39300   1.000 75.57000  ? 115 ALA A N    1 
ATOM   1676 C CA   . ALA A 1 115 ? 0.33400  -13.57600 8.39400   1.000 76.99000  ? 115 ALA A CA   1 
ATOM   1677 C C    . ALA A 1 115 ? 1.65500  -13.91500 9.07400   1.000 72.66000  ? 115 ALA A C    1 
ATOM   1678 O O    . ALA A 1 115 ? 1.99800  -13.39000 10.14900  1.000 49.05000  ? 115 ALA A O    1 
ATOM   1679 C CB   . ALA A 1 115 ? 0.52000  -12.46900 7.37000   1.000 67.47000  ? 115 ALA A CB   1 
ATOM   1680 H H    . ALA A 1 115 ? -0.93000 -12.38300 9.33000   1.000 90.56000  ? 115 ALA A H    1 
ATOM   1681 H HA   . ALA A 1 115 ? 0.02600  -14.36000 7.91300   1.000 92.26000  ? 115 ALA A HA   1 
ATOM   1682 H HB1  . ALA A 1 115 ? 1.18200  -12.75000 6.71900   1.000 80.84000  ? 115 ALA A HB1  1 
ATOM   1683 H HB2  . ALA A 1 115 ? -0.32800 -12.30100 6.92900   1.000 80.84000  ? 115 ALA A HB2  1 
ATOM   1684 H HB3  . ALA A 1 115 ? 0.82200  -11.66700 7.82400   1.000 80.84000  ? 115 ALA A HB3  1 
ATOM   1685 N N    . ASP A 1 116 ? 2.38800  -14.83500 8.46000   1.000 78.89000  ? 116 ASP A N    1 
ATOM   1686 C CA   . ASP A 1 116 ? 3.73500  -15.10900 8.94900   1.000 86.89000  ? 116 ASP A CA   1 
ATOM   1687 C C    . ASP A 1 116 ? 4.76300  -14.12300 8.37600   1.000 65.62000  ? 116 ASP A C    1 
ATOM   1688 O O    . ASP A 1 116 ? 4.64300  -13.64100 7.24600   1.000 57.30000  ? 116 ASP A O    1 
ATOM   1689 C CB   . ASP A 1 116 ? 4.16200  -16.52800 8.59700   1.000 71.17000  ? 116 ASP A CB   1 
ATOM   1690 C CG   . ASP A 1 116 ? 5.40000  -16.92000 9.31500   1.000 81.93000  ? 116 ASP A CG   1 
ATOM   1691 O OD1  . ASP A 1 116 ? 5.30100  -17.21100 10.52000  1.000 89.64000  ? 116 ASP A OD1  1 
ATOM   1692 O OD2  . ASP A 1 116 ? 6.47400  -16.88700 8.68500   1.000 89.89000  ? 116 ASP A OD2  1 
ATOM   1693 H H    . ASP A 1 116 ? 2.13800  -15.30000 7.78000   1.000 94.55000  ? 116 ASP A H    1 
ATOM   1694 H HA   . ASP A 1 116 ? 3.72900  -15.01200 9.91400   1.000 104.15000 ? 116 ASP A HA   1 
ATOM   1695 H HB2  . ASP A 1 116 ? 3.45700  -17.14600 8.84500   1.000 85.28000  ? 116 ASP A HB2  1 
ATOM   1696 H HB3  . ASP A 1 116 ? 4.33200  -16.58400 7.64300   1.000 85.28000  ? 116 ASP A HB3  1 
ATOM   1697 N N    . VAL A 1 117 ? 5.80000  -13.84800 9.16500   1.000 74.53000  ? 117 VAL A N    1 
ATOM   1698 C CA   . VAL A 1 117 ? 6.83400  -12.89800 8.74900   1.000 69.46000  ? 117 VAL A CA   1 
ATOM   1699 C C    . VAL A 1 117 ? 7.38700  -13.25200 7.36500   1.000 65.86000  ? 117 VAL A C    1 
ATOM   1700 O O    . VAL A 1 117 ? 7.75000  -12.36800 6.58600   1.000 52.30000  ? 117 VAL A O    1 
ATOM   1701 C CB   . VAL A 1 117 ? 7.95100  -12.85800 9.81500   1.000 58.88000  ? 117 VAL A CB   1 
ATOM   1702 C CG1  . VAL A 1 117 ? 9.08500  -11.95800 9.36200   1.000 51.24000  ? 117 VAL A CG1  1 
ATOM   1703 C CG2  . VAL A 1 117 ? 7.45500  -12.37900 11.18700  1.000 62.78000  ? 117 VAL A CG2  1 
ATOM   1704 H H    . VAL A 1 117 ? 5.93000  -14.19400 9.94100   1.000 89.31000  ? 117 VAL A H    1 
ATOM   1705 H HA   . VAL A 1 117 ? 6.43900  -12.01400 8.68300   1.000 83.22000  ? 117 VAL A HA   1 
ATOM   1706 H HB   . VAL A 1 117 ? 8.26700  -13.77000 9.91900   1.000 70.53000  ? 117 VAL A HB   1 
ATOM   1707 H HG11 . VAL A 1 117 ? 9.74700  -11.90400 10.06900  1.000 61.36000  ? 117 VAL A HG11 1 
ATOM   1708 H HG12 . VAL A 1 117 ? 9.48500  -12.33300 8.56200   1.000 61.36000  ? 117 VAL A HG12 1 
ATOM   1709 H HG13 . VAL A 1 117 ? 8.73100  -11.07600 9.17200   1.000 61.36000  ? 117 VAL A HG13 1 
ATOM   1710 H HG21 . VAL A 1 117 ? 8.20200  -12.36400 11.80600  1.000 75.21000  ? 117 VAL A HG21 1 
ATOM   1711 H HG22 . VAL A 1 117 ? 7.08300  -11.48800 11.09500  1.000 75.21000  ? 117 VAL A HG22 1 
ATOM   1712 H HG23 . VAL A 1 117 ? 6.77300  -12.99100 11.50700  1.000 75.21000  ? 117 VAL A HG23 1 
ATOM   1713 N N    . SER A 1 118 ? 7.39200  -14.53800 7.01400   1.000 56.60000  ? 118 SER A N    1 
ATOM   1714 C CA   . SER A 1 118 ? 7.91900  -14.99100 5.73600   1.000 55.19000  ? 118 SER A CA   1 
ATOM   1715 C C    . SER A 1 118 ? 7.14500  -14.46700 4.53600   1.000 47.68000  ? 118 SER A C    1 
ATOM   1716 O O    . SER A 1 118 ? 7.64800  -14.56900 3.40900   1.000 77.14000  ? 118 SER A O    1 
ATOM   1717 C CB   . SER A 1 118 ? 7.93200  -16.52500 5.73600   1.000 73.88000  ? 118 SER A CB   1 
ATOM   1718 O OG   . SER A 1 118 ? 6.82200  -17.00300 6.45100   1.000 73.23000  ? 118 SER A OG   1 
ATOM   1719 H H    . SER A 1 118 ? 7.09200  -15.17500 7.50800   1.000 67.80000  ? 118 SER A H    1 
ATOM   1720 H HA   . SER A 1 118 ? 8.82500  -14.66100 5.63400   1.000 66.11000  ? 118 SER A HA   1 
ATOM   1721 H HB2  . SER A 1 118 ? 7.88900  -16.84700 4.82200   1.000 88.54000  ? 118 SER A HB2  1 
ATOM   1722 H HB3  . SER A 1 118 ? 8.74700  -16.84000 6.15900   1.000 88.54000  ? 118 SER A HB3  1 
ATOM   1723 H HG   . SER A 1 118 ? 6.88600  -17.83400 6.56000   1.000 87.76000  ? 118 SER A HG   1 
ATOM   1724 N N    . MET A 1 119 ? 5.95800  -13.90500 4.73000   1.000 60.61000  ? 119 MET A N    1 
ATOM   1725 C CA   . MET A 1 119 ? 5.20100  -13.38400 3.59700   1.000 71.71000  ? 119 MET A CA   1 
ATOM   1726 C C    . MET A 1 119 ? 5.62900  -11.97100 3.21600   1.000 50.25000  ? 119 MET A C    1 
ATOM   1727 O O    . MET A 1 119 ? 4.97200  -11.32900 2.38500   1.000 68.21000  ? 119 MET A O    1 
ATOM   1728 C CB   . MET A 1 119 ? 3.68800  -13.37500 3.87600   1.000 71.78000  ? 119 MET A CB   1 
ATOM   1729 C CG   . MET A 1 119 ? 2.85000  -14.50600 3.25200   1.000 82.63000  ? 119 MET A CG   1 
ATOM   1730 S SD   . MET A 1 119 ? 1.29600  -14.74700 4.15500   1.000 119.97000 ? 119 MET A SD   1 
ATOM   1731 C CE   . MET A 1 119 ? 1.81200  -15.96500 5.44400   1.000 77.17000  ? 119 MET A CE   1 
ATOM   1732 H H    . MET A 1 119 ? 5.57600  -13.81500 5.49500   1.000 72.61000  ? 119 MET A H    1 
ATOM   1733 H HA   . MET A 1 119 ? 5.35100  -13.99200 2.85600   1.000 85.93000  ? 119 MET A HA   1 
ATOM   1734 H HB2  . MET A 1 119 ? 3.56100  -13.42800 4.83600   1.000 86.02000  ? 119 MET A HB2  1 
ATOM   1735 H HB3  . MET A 1 119 ? 3.32800  -12.53900 3.54000   1.000 86.02000  ? 119 MET A HB3  1 
ATOM   1736 H HG2  . MET A 1 119 ? 2.63900  -14.28100 2.33200   1.000 99.03000  ? 119 MET A HG2  1 
ATOM   1737 H HG3  . MET A 1 119 ? 3.35400  -15.33500 3.28300   1.000 99.03000  ? 119 MET A HG3  1 
ATOM   1738 H HE1  . MET A 1 119 ? 1.05600  -16.15200 6.02200   1.000 92.48000  ? 119 MET A HE1  1 
ATOM   1739 H HE2  . MET A 1 119 ? 2.10600  -16.78000 5.00900   1.000 92.48000  ? 119 MET A HE2  1 
ATOM   1740 H HE3  . MET A 1 119 ? 2.53900  -15.58600 5.96300   1.000 92.48000  ? 119 MET A HE3  1 
ATOM   1741 N N    . ILE A 1 120 ? 6.67100  -11.44000 3.86000   1.000 64.95000  ? 120 ILE A N    1 
ATOM   1742 C CA   . ILE A 1 120 ? 7.02600  -10.02700 3.68000   1.000 65.03000  ? 120 ILE A CA   1 
ATOM   1743 C C    . ILE A 1 120 ? 7.31800  -9.72100  2.19800   1.000 40.93000  ? 120 ILE A C    1 
ATOM   1744 O O    . ILE A 1 120 ? 6.95700  -8.65100  1.67800   1.000 55.28000  ? 120 ILE A O    1 
ATOM   1745 C CB   . ILE A 1 120 ? 8.20200  -9.67100  4.62900   1.000 52.18000  ? 120 ILE A CB   1 
ATOM   1746 C CG1  . ILE A 1 120 ? 8.47700  -8.17800  4.63800   1.000 51.24000  ? 120 ILE A CG1  1 
ATOM   1747 C CG2  . ILE A 1 120 ? 9.46500  -10.51200 4.29000   1.000 56.41000  ? 120 ILE A CG2  1 
ATOM   1748 C CD1  . ILE A 1 120 ? 9.60100  -7.71900  5.65000   1.000 50.85000  ? 120 ILE A CD1  1 
ATOM   1749 H H    . ILE A 1 120 ? 7.18400  -11.86800 4.40100   1.000 77.82000  ? 120 ILE A H    1 
ATOM   1750 H HA   . ILE A 1 120 ? 6.27300  -9.46600  3.92400   1.000 77.92000  ? 120 ILE A HA   1 
ATOM   1751 H HB   . ILE A 1 120 ? 7.94000  -9.90500  5.53300   1.000 62.49000  ? 120 ILE A HB   1 
ATOM   1752 H HG12 . ILE A 1 120 ? 8.75800  -7.91100  3.74900   1.000 61.37000  ? 120 ILE A HG12 1 
ATOM   1753 H HG13 . ILE A 1 120 ? 7.66000  -7.71600  4.88100   1.000 61.37000  ? 120 ILE A HG13 1 
ATOM   1754 H HG21 . ILE A 1 120 ? 10.13200 -10.37200 4.97900   1.000 67.56000  ? 120 ILE A HG21 1 
ATOM   1755 H HG22 . ILE A 1 120 ? 9.21900  -11.45000 4.25300   1.000 67.56000  ? 120 ILE A HG22 1 
ATOM   1756 H HG23 . ILE A 1 120 ? 9.81200  -10.22800 3.43000   1.000 67.56000  ? 120 ILE A HG23 1 
ATOM   1757 H HD11 . ILE A 1 120 ? 9.68100  -6.75300  5.61600   1.000 60.90000  ? 120 ILE A HD11 1 
ATOM   1758 H HD12 . ILE A 1 120 ? 9.35400  -7.99900  6.54500   1.000 60.90000  ? 120 ILE A HD12 1 
ATOM   1759 H HD13 . ILE A 1 120 ? 10.44200 -8.13000  5.39500   1.000 60.90000  ? 120 ILE A HD13 1 
ATOM   1760 N N    . GLY A 1 121 ? 7.96200  -10.63400 1.49400   1.000 53.74000  ? 121 GLY A N    1 
ATOM   1761 C CA   . GLY A 1 121 ? 8.31500  -10.34200 0.12300   1.000 51.72000  ? 121 GLY A CA   1 
ATOM   1762 C C    . GLY A 1 121 ? 7.13000  -10.08300 -0.78500  1.000 53.61000  ? 121 GLY A C    1 
ATOM   1763 O O    . GLY A 1 121 ? 7.25400  -9.34500  -1.76900  1.000 54.82000  ? 121 GLY A O    1 
ATOM   1764 H H    . GLY A 1 121 ? 8.19900  -11.41000 1.77900   1.000 64.37000  ? 121 GLY A H    1 
ATOM   1765 H HA2  . GLY A 1 121 ? 8.88100  -9.55400  0.10600   1.000 61.94000  ? 121 GLY A HA2  1 
ATOM   1766 H HA3  . GLY A 1 121 ? 8.81000  -11.09300 -0.24000  1.000 61.94000  ? 121 GLY A HA3  1 
ATOM   1767 N N    . GLN A 1 122 ? 5.97100  -10.68200 -0.47100  1.000 50.26000  ? 122 GLN A N    1 
ATOM   1768 C CA   . GLN A 1 122 ? 4.78500  -10.56800 -1.31100  1.000 57.37000  ? 122 GLN A CA   1 
ATOM   1769 C C    . GLN A 1 122 ? 4.22100  -9.15600  -1.34400  1.000 50.78000  ? 122 GLN A C    1 
ATOM   1770 O O    . GLN A 1 122 ? 3.47000  -8.82300  -2.27000  1.000 69.58000  ? 122 GLN A O    1 
ATOM   1771 C CB   . GLN A 1 122 ? 3.67300  -11.50600 -0.81900  1.000 91.14000  ? 122 GLN A CB   1 
ATOM   1772 C CG   . GLN A 1 122 ? 4.07800  -12.91700 -0.46000  1.000 81.64000  ? 122 GLN A CG   1 
ATOM   1773 C CD   . GLN A 1 122 ? 4.20000  -13.80200 -1.64000  1.000 87.00000  ? 122 GLN A CD   1 
ATOM   1774 O OE1  . GLN A 1 122 ? 5.24000  -13.81300 -2.31500  1.000 88.56000  ? 122 GLN A OE1  1 
ATOM   1775 N NE2  . GLN A 1 122 ? 3.11500  -14.54800 -1.93600  1.000 86.23000  ? 122 GLN A NE2  1 
ATOM   1776 H H    . GLN A 1 122 ? 5.85100  -11.16400 0.23100   1.000 60.19000  ? 122 GLN A H    1 
ATOM   1777 H HA   . GLN A 1 122 ? 5.04500  -10.83000 -2.20800  1.000 68.72000  ? 122 GLN A HA   1 
ATOM   1778 H HB2  . GLN A 1 122 ? 3.28000  -11.11400 -0.02400  1.000 109.24000 ? 122 GLN A HB2  1 
ATOM   1779 H HB3  . GLN A 1 122 ? 3.00600  -11.57300 -1.52000  1.000 109.24000 ? 122 GLN A HB3  1 
ATOM   1780 H HG2  . GLN A 1 122 ? 4.93800  -12.89400 -0.01300  1.000 97.84000  ? 122 GLN A HG2  1 
ATOM   1781 H HG3  . GLN A 1 122 ? 3.40800  -13.29700 0.13000   1.000 97.84000  ? 122 GLN A HG3  1 
ATOM   1782 H HE21 . GLN A 1 122 ? 2.40800  -14.49100 -1.45000  1.000 103.35000 ? 122 GLN A HE21 1 
ATOM   1783 H HE22 . GLN A 1 122 ? 3.13100  -15.08000 -2.61200  1.000 103.35000 ? 122 GLN A HE22 1 
ATOM   1784 N N    . PHE A 1 123 ? 4.52700  -8.34600  -0.33600  1.000 38.54000  ? 123 PHE A N    1 
ATOM   1785 C CA   . PHE A 1 123 ? 4.14400  -6.94600  -0.23600  1.000 46.41000  ? 123 PHE A CA   1 
ATOM   1786 C C    . PHE A 1 123 ? 5.25400  -6.01800  -0.67700  1.000 48.83000  ? 123 PHE A C    1 
ATOM   1787 O O    . PHE A 1 123 ? 5.07600  -4.80200  -0.62200  1.000 50.65000  ? 123 PHE A O    1 
ATOM   1788 C CB   . PHE A 1 123 ? 3.70000  -6.60500  1.21400   1.000 50.64000  ? 123 PHE A CB   1 
ATOM   1789 C CG   . PHE A 1 123 ? 2.53100  -7.43600  1.67200   1.000 46.55000  ? 123 PHE A CG   1 
ATOM   1790 C CD1  . PHE A 1 123 ? 2.75600  -8.71200  2.18600   1.000 63.90000  ? 123 PHE A CD1  1 
ATOM   1791 C CD2  . PHE A 1 123 ? 1.21700  -7.00900  1.47200   1.000 55.27000  ? 123 PHE A CD2  1 
ATOM   1792 C CE1  . PHE A 1 123 ? 1.72200  -9.52000  2.55500   1.000 59.65000  ? 123 PHE A CE1  1 
ATOM   1793 C CE2  . PHE A 1 123 ? 0.16500  -7.82000  1.82900   1.000 67.45000  ? 123 PHE A CE2  1 
ATOM   1794 C CZ   . PHE A 1 123 ? 0.41900  -9.10500  2.36600   1.000 43.75000  ? 123 PHE A CZ   1 
ATOM   1795 H H    . PHE A 1 123 ? 4.98600  -8.60300  0.34500   1.000 46.13000  ? 123 PHE A H    1 
ATOM   1796 H HA   . PHE A 1 123 ? 3.37700  -6.78700  -0.80900  1.000 55.56000  ? 123 PHE A HA   1 
ATOM   1797 H HB2  . PHE A 1 123 ? 4.44100  -6.76800  1.81900   1.000 60.64000  ? 123 PHE A HB2  1 
ATOM   1798 H HB3  . PHE A 1 123 ? 3.43900  -5.67100  1.25400   1.000 60.64000  ? 123 PHE A HB3  1 
ATOM   1799 H HD1  . PHE A 1 123 ? 3.62900  -9.01800  2.27800   1.000 76.56000  ? 123 PHE A HD1  1 
ATOM   1800 H HD2  . PHE A 1 123 ? 1.05300  -6.17400  1.09600   1.000 66.20000  ? 123 PHE A HD2  1 
ATOM   1801 H HE1  . PHE A 1 123 ? 1.89500  -10.35200 2.93400   1.000 71.46000  ? 123 PHE A HE1  1 
ATOM   1802 H HE2  . PHE A 1 123 ? -0.71100 -7.52500  1.71800   1.000 80.82000  ? 123 PHE A HE2  1 
ATOM   1803 H HZ   . PHE A 1 123 ? -0.28800 -9.66600  2.59000   1.000 52.37000  ? 123 PHE A HZ   1 
ATOM   1804 N N    . GLY A 1 124 ? 6.37700  -6.56100  -1.13500  1.000 51.96000  ? 124 GLY A N    1 
ATOM   1805 C CA   . GLY A 1 124 ? 7.46700  -5.78100  -1.70200  1.000 60.31000  ? 124 GLY A CA   1 
ATOM   1806 C C    . GLY A 1 124 ? 8.41000  -5.08000  -0.74400  1.000 45.70000  ? 124 GLY A C    1 
ATOM   1807 O O    . GLY A 1 124 ? 9.12600  -4.16800  -1.18100  1.000 48.15000  ? 124 GLY A O    1 
ATOM   1808 H H    . GLY A 1 124 ? 6.53600  -7.40600  -1.12800  1.000 62.22000  ? 124 GLY A H    1 
ATOM   1809 H HA2  . GLY A 1 124 ? 8.00700  -6.37400  -2.24700  1.000 72.25000  ? 124 GLY A HA2  1 
ATOM   1810 H HA3  . GLY A 1 124 ? 7.08000  -5.09600  -2.26900  1.000 72.25000  ? 124 GLY A HA3  1 
ATOM   1811 N N    . VAL A 1 125 ? 8.39500  -5.42600  0.54500   1.000 53.39000  ? 125 VAL A N    1 
ATOM   1812 C CA   . VAL A 1 125 ? 9.24000  -4.76100  1.52300   1.000 42.33000  ? 125 VAL A CA   1 
ATOM   1813 C C    . VAL A 1 125 ? 10.15900 -5.73900  2.20900   1.000 43.03000  ? 125 VAL A C    1 
ATOM   1814 O O    . VAL A 1 125 ? 10.50500 -5.51500  3.36300   1.000 44.50000  ? 125 VAL A O    1 
ATOM   1815 C CB   . VAL A 1 125 ? 8.40700  -4.02300  2.58900   1.000 48.11000  ? 125 VAL A CB   1 
ATOM   1816 C CG1  . VAL A 1 125 ? 7.73000  -2.82400  1.94900   1.000 44.38000  ? 125 VAL A CG1  1 
ATOM   1817 C CG2  . VAL A 1 125 ? 7.33600  -4.91800  3.24500   1.000 44.70000  ? 125 VAL A CG2  1 
ATOM   1818 H H    . VAL A 1 125 ? 7.89900  -6.04700  0.87400   1.000 63.94000  ? 125 VAL A H    1 
ATOM   1819 H HA   . VAL A 1 125 ? 9.78300  -4.12700  1.02900   1.000 50.68000  ? 125 VAL A HA   1 
ATOM   1820 H HB   . VAL A 1 125 ? 9.01400  -3.74500  3.29400   1.000 57.61000  ? 125 VAL A HB   1 
ATOM   1821 H HG11 . VAL A 1 125 ? 6.83200  -2.74100  2.30600   1.000 53.13000  ? 125 VAL A HG11 1 
ATOM   1822 H HG12 . VAL A 1 125 ? 8.24200  -2.02600  2.15300   1.000 53.13000  ? 125 VAL A HG12 1 
ATOM   1823 H HG13 . VAL A 1 125 ? 7.69400  -2.95800  0.98900   1.000 53.13000  ? 125 VAL A HG13 1 
ATOM   1824 H HG21 . VAL A 1 125 ? 6.85500  -4.40000  3.91000   1.000 53.51000  ? 125 VAL A HG21 1 
ATOM   1825 H HG22 . VAL A 1 125 ? 6.72200  -5.22800  2.56000   1.000 53.51000  ? 125 VAL A HG22 1 
ATOM   1826 H HG23 . VAL A 1 125 ? 7.77200  -5.67500  3.66600   1.000 53.51000  ? 125 VAL A HG23 1 
ATOM   1827 N N    . GLY A 1 126 ? 10.57700 -6.80400  1.52000   1.000 42.44000  ? 126 GLY A N    1 
ATOM   1828 C CA   . GLY A 1 126 ? 11.40400 -7.82300  2.16700   1.000 49.39000  ? 126 GLY A CA   1 
ATOM   1829 C C    . GLY A 1 126 ? 12.81400 -7.38800  2.57900   1.000 45.49000  ? 126 GLY A C    1 
ATOM   1830 O O    . GLY A 1 126 ? 13.45700 -8.06100  3.39000   1.000 43.83000  ? 126 GLY A O    1 
ATOM   1831 H H    . GLY A 1 126 ? 10.40000 -6.95700  0.69200   1.000 50.80000  ? 126 GLY A H    1 
ATOM   1832 H HA2  . GLY A 1 126 ? 10.94800 -8.12300  2.96800   1.000 59.14000  ? 126 GLY A HA2  1 
ATOM   1833 H HA3  . GLY A 1 126 ? 11.49800 -8.57200  1.55800   1.000 59.14000  ? 126 GLY A HA3  1 
ATOM   1834 N N    . PHE A 1 127 ? 13.32100 -6.28800  2.00400   1.000 46.52000  ? 127 PHE A N    1 
ATOM   1835 C CA   . PHE A 1 127 ? 14.53900 -5.63800  2.50700   1.000 44.11000  ? 127 PHE A CA   1 
ATOM   1836 C C    . PHE A 1 127 ? 14.51100 -5.53800  4.02600   1.000 56.96000  ? 127 PHE A C    1 
ATOM   1837 O O    . PHE A 1 127 ? 15.50000 -5.87200  4.70000   1.000 30.57000  ? 127 PHE A O    1 
ATOM   1838 C CB   . PHE A 1 127 ? 14.69700 -4.22600  1.90100   1.000 40.53000  ? 127 PHE A CB   1 
ATOM   1839 C CG   . PHE A 1 127 ? 15.80100 -3.36800  2.52400   1.000 52.07000  ? 127 PHE A CG   1 
ATOM   1840 C CD1  . PHE A 1 127 ? 17.15200 -3.55000  2.19600   1.000 45.78000  ? 127 PHE A CD1  1 
ATOM   1841 C CD2  . PHE A 1 127 ? 15.47200 -2.31400  3.39600   1.000 49.36000  ? 127 PHE A CD2  1 
ATOM   1842 C CE1  . PHE A 1 127 ? 18.16400 -2.71400  2.77300   1.000 41.39000  ? 127 PHE A CE1  1 
ATOM   1843 C CE2  . PHE A 1 127 ? 16.45800 -1.48400  3.94300   1.000 55.90000  ? 127 PHE A CE2  1 
ATOM   1844 C CZ   . PHE A 1 127 ? 17.79900 -1.68900  3.63800   1.000 58.42000  ? 127 PHE A CZ   1 
ATOM   1845 H H    . PHE A 1 127 ? 12.97800 -5.89700  1.31900   1.000 55.70000  ? 127 PHE A H    1 
ATOM   1846 H HA   . PHE A 1 127 ? 15.30200 -6.17000  2.23200   1.000 52.81000  ? 127 PHE A HA   1 
ATOM   1847 H HB2  . PHE A 1 127 ? 14.90100 -4.31900  0.95700   1.000 48.52000  ? 127 PHE A HB2  1 
ATOM   1848 H HB3  . PHE A 1 127 ? 13.86000 -3.74900  2.01400   1.000 48.52000  ? 127 PHE A HB3  1 
ATOM   1849 H HD1  . PHE A 1 127 ? 17.39400 -4.22000  1.59800   1.000 54.81000  ? 127 PHE A HD1  1 
ATOM   1850 H HD2  . PHE A 1 127 ? 14.58000 -2.16600  3.61500   1.000 59.10000  ? 127 PHE A HD2  1 
ATOM   1851 H HE1  . PHE A 1 127 ? 19.06000 -2.85700  2.57000   1.000 49.55000  ? 127 PHE A HE1  1 
ATOM   1852 H HE2  . PHE A 1 127 ? 16.21400 -0.79100  4.51300   1.000 66.96000  ? 127 PHE A HE2  1 
ATOM   1853 H HZ   . PHE A 1 127 ? 18.45100 -1.14200  4.01200   1.000 69.99000  ? 127 PHE A HZ   1 
ATOM   1854 N N    . TYR A 1 128 ? 13.37000 -5.09300  4.58700   1.000 31.91000  ? 128 TYR A N    1 
ATOM   1855 C CA   . TYR A 1 128 ? 13.35500 -4.86500  6.02500   1.000 59.14000  ? 128 TYR A CA   1 
ATOM   1856 C C    . TYR A 1 128 ? 13.42200 -6.17300  6.81900   1.000 50.47000  ? 128 TYR A C    1 
ATOM   1857 O O    . TYR A 1 128 ? 13.60400 -6.11300  8.03800   1.000 45.30000  ? 128 TYR A O    1 
ATOM   1858 C CB   . TYR A 1 128 ? 12.14600 -3.98200  6.38400   1.000 42.96000  ? 128 TYR A CB   1 
ATOM   1859 C CG   . TYR A 1 128 ? 12.27600 -2.56600  5.77800   1.000 55.00000  ? 128 TYR A CG   1 
ATOM   1860 C CD1  . TYR A 1 128 ? 13.22500 -1.63700  6.26800   1.000 61.57000  ? 128 TYR A CD1  1 
ATOM   1861 C CD2  . TYR A 1 128 ? 11.48000 -2.16500  4.70100   1.000 48.14000  ? 128 TYR A CD2  1 
ATOM   1862 C CE1  . TYR A 1 128 ? 13.38200 -0.34000  5.66300   1.000 58.60000  ? 128 TYR A CE1  1 
ATOM   1863 C CE2  . TYR A 1 128 ? 11.65400 -0.90400  4.08600   1.000 48.21000  ? 128 TYR A CE2  1 
ATOM   1864 C CZ   . TYR A 1 128 ? 12.56700 0.01100   4.57400   1.000 63.54000  ? 128 TYR A CZ   1 
ATOM   1865 O OH   . TYR A 1 128 ? 12.64100 1.25900   3.95400   1.000 73.06000  ? 128 TYR A OH   1 
ATOM   1866 H H    . TYR A 1 128 ? 12.63700 -4.92700  4.17100   1.000 38.17000  ? 128 TYR A H    1 
ATOM   1867 H HA   . TYR A 1 128 ? 14.13400 -4.36100  6.30700   1.000 70.85000  ? 128 TYR A HA   1 
ATOM   1868 H HB2  . TYR A 1 128 ? 11.33700 -4.38900  6.03700   1.000 51.43000  ? 128 TYR A HB2  1 
ATOM   1869 H HB3  . TYR A 1 128 ? 12.08700 -3.89600  7.34900   1.000 51.43000  ? 128 TYR A HB3  1 
ATOM   1870 H HD1  . TYR A 1 128 ? 13.75700 -1.86900  6.99400   1.000 73.76000  ? 128 TYR A HD1  1 
ATOM   1871 H HD2  . TYR A 1 128 ? 10.82200 -2.73900  4.38200   1.000 57.64000  ? 128 TYR A HD2  1 
ATOM   1872 H HE1  . TYR A 1 128 ? 14.01600 0.25700   5.98900   1.000 70.20000  ? 128 TYR A HE1  1 
ATOM   1873 H HE2  . TYR A 1 128 ? 11.14400 -0.68600  3.33900   1.000 57.73000  ? 128 TYR A HE2  1 
ATOM   1874 H HH   . TYR A 1 128 ? 12.16000 1.26700   3.26600   1.000 87.55000  ? 128 TYR A HH   1 
ATOM   1875 N N    . SER A 1 129 ? 13.39900 -7.34500  6.16000   1.000 47.54000  ? 129 SER A N    1 
ATOM   1876 C CA   . SER A 1 129 ? 13.57000 -8.57900  6.92300   1.000 40.44000  ? 129 SER A CA   1 
ATOM   1877 C C    . SER A 1 129 ? 14.98000 -8.69500  7.48900   1.000 41.03000  ? 129 SER A C    1 
ATOM   1878 O O    . SER A 1 129 ? 15.23000 -9.52000  8.36600   1.000 49.35000  ? 129 SER A O    1 
ATOM   1879 C CB   . SER A 1 129 ? 13.24800 -9.81500  6.06900   1.000 46.69000  ? 129 SER A CB   1 
ATOM   1880 O OG   . SER A 1 129 ? 14.31500 -10.14600 5.21000   1.000 44.83000  ? 129 SER A OG   1 
ATOM   1881 H H    . SER A 1 129 ? 13.29200 -7.44200  5.31200   1.000 56.92000  ? 129 SER A H    1 
ATOM   1882 H HA   . SER A 1 129 ? 12.93500 -8.57300  7.65600   1.000 48.41000  ? 129 SER A HA   1 
ATOM   1883 H HB2  . SER A 1 129 ? 13.07700 -10.56600 6.65900   1.000 55.90000  ? 129 SER A HB2  1 
ATOM   1884 H HB3  . SER A 1 129 ? 12.46100 -9.62800  5.53300   1.000 55.90000  ? 129 SER A HB3  1 
ATOM   1885 H HG   . SER A 1 129 ? 14.33600 -9.61400  4.56000   1.000 53.67000  ? 129 SER A HG   1 
ATOM   1886 N N    . LEU A 1 130 ? 15.91900 -7.91300  6.97400   1.000 38.76000  ? 130 LEU A N    1 
ATOM   1887 C CA   . LEU A 1 130 ? 17.27500 -8.00800  7.47300   1.000 51.50000  ? 130 LEU A CA   1 
ATOM   1888 C C    . LEU A 1 130 ? 17.35300 -7.75100  8.96300   1.000 44.91000  ? 130 LEU A C    1 
ATOM   1889 O O    . LEU A 1 130 ? 18.25700 -8.25800  9.59700   1.000 50.82000  ? 130 LEU A O    1 
ATOM   1890 C CB   . LEU A 1 130 ? 18.18400 -7.03400  6.72100   1.000 44.49000  ? 130 LEU A CB   1 
ATOM   1891 C CG   . LEU A 1 130 ? 18.06100 -5.51200  6.97700   1.000 52.90000  ? 130 LEU A CG   1 
ATOM   1892 C CD1  . LEU A 1 130 ? 18.95200 -5.10700  8.15300   1.000 49.60000  ? 130 LEU A CD1  1 
ATOM   1893 C CD2  . LEU A 1 130 ? 18.35900 -4.67900  5.70300   1.000 47.36000  ? 130 LEU A CD2  1 
ATOM   1894 H H    . LEU A 1 130 ? 15.79700 -7.33400  6.35000   1.000 46.39000  ? 130 LEU A H    1 
ATOM   1895 H HA   . LEU A 1 130 ? 17.60500 -8.90500  7.30900   1.000 61.68000  ? 130 LEU A HA   1 
ATOM   1896 H HB2  . LEU A 1 130 ? 19.09900 -7.27200  6.93600   1.000 53.26000  ? 130 LEU A HB2  1 
ATOM   1897 H HB3  . LEU A 1 130 ? 18.02100 -7.16300  5.77400   1.000 53.26000  ? 130 LEU A HB3  1 
ATOM   1898 H HG   . LEU A 1 130 ? 17.14300 -5.30700  7.21400   1.000 63.36000  ? 130 LEU A HG   1 
ATOM   1899 H HD11 . LEU A 1 130 ? 19.09800 -4.14900  8.12300   1.000 59.39000  ? 130 LEU A HD11 1 
ATOM   1900 H HD12 . LEU A 1 130 ? 18.51100 -5.34900  8.98200   1.000 59.39000  ? 130 LEU A HD12 1 
ATOM   1901 H HD13 . LEU A 1 130 ? 19.80000 -5.57300  8.08100   1.000 59.39000  ? 130 LEU A HD13 1 
ATOM   1902 H HD21 . LEU A 1 130 ? 18.13000 -3.75100  5.87200   1.000 56.71000  ? 130 LEU A HD21 1 
ATOM   1903 H HD22 . LEU A 1 130 ? 19.30200 -4.75400  5.48900   1.000 56.71000  ? 130 LEU A HD22 1 
ATOM   1904 H HD23 . LEU A 1 130 ? 17.82500 -5.02300  4.96900   1.000 56.71000  ? 130 LEU A HD23 1 
ATOM   1905 N N    . PHE A 1 131 ? 16.42900 -7.00800  9.54900   1.000 44.71000  ? 131 PHE A N    1 
ATOM   1906 C CA   . PHE A 1 131 ? 16.48200 -6.73000  10.98200  1.000 63.82000  ? 131 PHE A CA   1 
ATOM   1907 C C    . PHE A 1 131 ? 16.09800 -7.92600  11.85200  1.000 55.22000  ? 131 PHE A C    1 
ATOM   1908 O O    . PHE A 1 131 ? 16.27800 -7.87500  13.06000  1.000 48.65000  ? 131 PHE A O    1 
ATOM   1909 C CB   . PHE A 1 131 ? 15.62100 -5.50700  11.25600  1.000 49.54000  ? 131 PHE A CB   1 
ATOM   1910 C CG   . PHE A 1 131 ? 16.20700 -4.19300  10.66700  1.000 40.38000  ? 131 PHE A CG   1 
ATOM   1911 C CD1  . PHE A 1 131 ? 17.29600 -3.56700  11.24900  1.000 51.50000  ? 131 PHE A CD1  1 
ATOM   1912 C CD2  . PHE A 1 131 ? 15.64000 -3.58700  9.55100   1.000 39.87000  ? 131 PHE A CD2  1 
ATOM   1913 C CE1  . PHE A 1 131 ? 17.77200 -2.34400  10.72800  1.000 60.66000  ? 131 PHE A CE1  1 
ATOM   1914 C CE2  . PHE A 1 131 ? 16.11100 -2.38700  9.04200   1.000 49.12000  ? 131 PHE A CE2  1 
ATOM   1915 C CZ   . PHE A 1 131 ? 17.16700 -1.77200  9.61400   1.000 58.59000  ? 131 PHE A CZ   1 
ATOM   1916 H H    . PHE A 1 131 ? 15.76000 -6.65100  9.14300   1.000 53.52000  ? 131 PHE A H    1 
ATOM   1917 H HA   . PHE A 1 131 ? 17.38800 -6.51500  11.25300  1.000 76.47000  ? 131 PHE A HA   1 
ATOM   1918 H HB2  . PHE A 1 131 ? 14.74600 -5.64600  10.86200  1.000 59.33000  ? 131 PHE A HB2  1 
ATOM   1919 H HB3  . PHE A 1 131 ? 15.53800 -5.39200  12.21600  1.000 59.33000  ? 131 PHE A HB3  1 
ATOM   1920 H HD1  . PHE A 1 131 ? 17.71600 -3.95200  11.98400  1.000 61.68000  ? 131 PHE A HD1  1 
ATOM   1921 H HD2  . PHE A 1 131 ? 14.92000 -4.00100  9.13300   1.000 47.72000  ? 131 PHE A HD2  1 
ATOM   1922 H HE1  . PHE A 1 131 ? 18.49400 -1.91900  11.13100  1.000 72.67000  ? 131 PHE A HE1  1 
ATOM   1923 H HE2  . PHE A 1 131 ? 15.69700 -2.00300  8.30300   1.000 58.82000  ? 131 PHE A HE2  1 
ATOM   1924 H HZ   . PHE A 1 131 ? 17.48800 -0.97100  9.26600   1.000 70.19000  ? 131 PHE A HZ   1 
ATOM   1925 N N    . LEU A 1 132 ? 15.70000 -9.04300  11.26400  1.000 37.17000  ? 132 LEU A N    1 
ATOM   1926 C CA   . LEU A 1 132 ? 15.63900 -10.29600 11.99700  1.000 50.32000  ? 132 LEU A CA   1 
ATOM   1927 C C    . LEU A 1 132 ? 16.99400 -10.69600 12.55900  1.000 49.09000  ? 132 LEU A C    1 
ATOM   1928 O O    . LEU A 1 132 ? 17.09200 -11.15700 13.70400  1.000 60.92000  ? 132 LEU A O    1 
ATOM   1929 C CB   . LEU A 1 132 ? 15.09300 -11.37100 11.07800  1.000 43.36000  ? 132 LEU A CB   1 
ATOM   1930 C CG   . LEU A 1 132 ? 13.63200 -11.17300 10.70900  1.000 47.62000  ? 132 LEU A CG   1 
ATOM   1931 C CD1  . LEU A 1 132 ? 13.36200 -11.96000 9.45700   1.000 46.45000  ? 132 LEU A CD1  1 
ATOM   1932 C CD2  . LEU A 1 132 ? 12.76200 -11.57300 11.84300  1.000 58.84000  ? 132 LEU A CD2  1 
ATOM   1933 H H    . LEU A 1 132 ? 15.45900 -9.10300  10.44000  1.000 44.49000  ? 132 LEU A H    1 
ATOM   1934 H HA   . LEU A 1 132 ? 15.04200 -10.19400 12.75500  1.000 60.26000  ? 132 LEU A HA   1 
ATOM   1935 H HB2  . LEU A 1 132 ? 15.61000 -11.37200 10.25700  1.000 51.90000  ? 132 LEU A HB2  1 
ATOM   1936 H HB3  . LEU A 1 132 ? 15.17400 -12.23000 11.52200  1.000 51.90000  ? 132 LEU A HB3  1 
ATOM   1937 H HG   . LEU A 1 132 ? 13.42700 -10.24200 10.53100  1.000 57.03000  ? 132 LEU A HG   1 
ATOM   1938 H HD11 . LEU A 1 132 ? 12.41100 -11.93400 9.26600   1.000 55.62000  ? 132 LEU A HD11 1 
ATOM   1939 H HD12 . LEU A 1 132 ? 13.85700 -11.56500 8.72200   1.000 55.62000  ? 132 LEU A HD12 1 
ATOM   1940 H HD13 . LEU A 1 132 ? 13.64600 -12.87700 9.59200   1.000 55.62000  ? 132 LEU A HD13 1 
ATOM   1941 H HD21 . LEU A 1 132 ? 11.83400 -11.51600 11.56500  1.000 70.49000  ? 132 LEU A HD21 1 
ATOM   1942 H HD22 . LEU A 1 132 ? 12.97500 -12.48400 12.09900  1.000 70.49000  ? 132 LEU A HD22 1 
ATOM   1943 H HD23 . LEU A 1 132 ? 12.92000 -10.97400 12.58900  1.000 70.49000  ? 132 LEU A HD23 1 
ATOM   1944 N N    . VAL A 1 133 ? 18.06100 -10.47300 11.80000  1.000 52.87000  ? 133 VAL A N    1 
ATOM   1945 C CA   . VAL A 1 133 ? 19.37100 -10.96300 12.19700  1.000 40.31000  ? 133 VAL A CA   1 
ATOM   1946 C C    . VAL A 1 133 ? 20.36100 -9.84200  12.46900  1.000 55.10000  ? 133 VAL A C    1 
ATOM   1947 O O    . VAL A 1 133 ? 21.47000 -10.12600 12.97500  1.000 46.67000  ? 133 VAL A O    1 
ATOM   1948 C CB   . VAL A 1 133 ? 19.93000 -11.97800 11.17100  1.000 54.16000  ? 133 VAL A CB   1 
ATOM   1949 C CG1  . VAL A 1 133 ? 18.99900 -13.22900 11.08800  1.000 60.18000  ? 133 VAL A CG1  1 
ATOM   1950 C CG2  . VAL A 1 133 ? 20.11000 -11.36100 9.71900   1.000 46.85000  ? 133 VAL A CG2  1 
ATOM   1951 H H    . VAL A 1 133 ? 18.04900 -10.04400 11.05500  1.000 63.33000  ? 133 VAL A H    1 
ATOM   1952 H HA   . VAL A 1 133 ? 19.27300 -11.43900 13.03700  1.000 48.25000  ? 133 VAL A HA   1 
ATOM   1953 H HB   . VAL A 1 133 ? 20.81100 -12.23700 11.48300  1.000 64.86000  ? 133 VAL A HB   1 
ATOM   1954 H HG11 . VAL A 1 133 ? 19.39100 -13.87500 10.48000  1.000 72.10000  ? 133 VAL A HG11 1 
ATOM   1955 H HG12 . VAL A 1 133 ? 18.91300 -13.61700 11.97300  1.000 72.10000  ? 133 VAL A HG12 1 
ATOM   1956 H HG13 . VAL A 1 133 ? 18.12800 -12.95300 10.76200  1.000 72.10000  ? 133 VAL A HG13 1 
ATOM   1957 H HG21 . VAL A 1 133 ? 20.44000 -12.05000 9.12200   1.000 56.09000  ? 133 VAL A HG21 1 
ATOM   1958 H HG22 . VAL A 1 133 ? 19.25200 -11.03500 9.40600   1.000 56.09000  ? 133 VAL A HG22 1 
ATOM   1959 H HG23 . VAL A 1 133 ? 20.74500 -10.62900 9.76400   1.000 56.09000  ? 133 VAL A HG23 1 
ATOM   1960 N N    . ALA A 1 134 ? 19.97000 -8.57300  12.26400  1.000 50.88000  ? 134 ALA A N    1 
ATOM   1961 C CA   . ALA A 1 134 ? 20.90800 -7.45700  12.39200  1.000 46.50000  ? 134 ALA A CA   1 
ATOM   1962 C C    . ALA A 1 134 ? 20.25900 -6.30200  13.12800  1.000 50.54000  ? 134 ALA A C    1 
ATOM   1963 O O    . ALA A 1 134 ? 19.08200 -5.99300  12.88800  1.000 54.74000  ? 134 ALA A O    1 
ATOM   1964 C CB   . ALA A 1 134 ? 21.38000 -6.98500  11.00900  1.000 56.45000  ? 134 ALA A CB   1 
ATOM   1965 H H    . ALA A 1 134 ? 19.17100 -8.34000  12.05100  1.000 60.93000  ? 134 ALA A H    1 
ATOM   1966 H HA   . ALA A 1 134 ? 21.67500 -7.74200  12.91500  1.000 55.68000  ? 134 ALA A HA   1 
ATOM   1967 H HB1  . ALA A 1 134 ? 22.02200 -6.26700  11.12200  1.000 67.62000  ? 134 ALA A HB1  1 
ATOM   1968 H HB2  . ALA A 1 134 ? 21.79500 -7.72900  10.54500  1.000 67.62000  ? 134 ALA A HB2  1 
ATOM   1969 H HB3  . ALA A 1 134 ? 20.61400 -6.66700  10.50500  1.000 67.62000  ? 134 ALA A HB3  1 
ATOM   1970 N N    . ASP A 1 135 ? 21.05400 -5.58800  13.91600  1.000 62.70000  ? 135 ASP A N    1 
ATOM   1971 C CA   . ASP A 1 135 ? 20.57600 -4.42300  14.69700  1.000 67.72000  ? 135 ASP A CA   1 
ATOM   1972 C C    . ASP A 1 135 ? 20.92700 -3.13000  13.97000  1.000 59.42000  ? 135 ASP A C    1 
ATOM   1973 O O    . ASP A 1 135 ? 20.30600 -2.11200  14.27800  1.000 78.69000  ? 135 ASP A O    1 
ATOM   1974 C CB   . ASP A 1 135 ? 21.17800 -4.46500  16.08700  1.000 78.33000  ? 135 ASP A CB   1 
ATOM   1975 C CG   . ASP A 1 135 ? 22.69000 -4.34400  16.18400  1.000 69.84000  ? 135 ASP A CG   1 
ATOM   1976 O OD1  . ASP A 1 135 ? 23.36600 -4.59200  15.17200  1.000 84.49000  ? 135 ASP A OD1  1 
ATOM   1977 O OD2  . ASP A 1 135 ? 23.17500 -4.01800  17.28100  1.000 86.15000  ? 135 ASP A OD2  1 
ATOM   1978 H H    . ASP A 1 135 ? 21.93100 -5.78000  14.01300  1.000 75.11000  ? 135 ASP A H    1 
ATOM   1979 H HA   . ASP A 1 135 ? 19.60300 -4.48100  14.79200  1.000 81.14000  ? 135 ASP A HA   1 
ATOM   1980 H HB2  . ASP A 1 135 ? 20.78100 -3.74400  16.61800  1.000 93.87000  ? 135 ASP A HB2  1 
ATOM   1981 H HB3  . ASP A 1 135 ? 20.92000 -5.31700  16.49700  1.000 93.87000  ? 135 ASP A HB3  1 
ATOM   1982 N N    . HIS A 1 136 ? 21.86900 -3.17200  13.04100  1.000 63.31000  ? 136 HIS A N    1 
ATOM   1983 C CA   . HIS A 1 136 ? 22.35300 -1.97400  12.31600  1.000 62.82000  ? 136 HIS A CA   1 
ATOM   1984 C C    . HIS A 1 136 ? 22.67400 -2.44200  10.90200  1.000 57.50000  ? 136 HIS A C    1 
ATOM   1985 O O    . HIS A 1 136 ? 22.86000 -3.63100  10.72600  1.000 49.69000  ? 136 HIS A O    1 
ATOM   1986 C CB   . HIS A 1 136 ? 23.48000 -1.34500  13.14000  1.000 52.54000  ? 136 HIS A CB   1 
ATOM   1987 C CG   . HIS A 1 136 ? 24.51300 -0.58200  12.39800  1.000 61.74000  ? 136 HIS A CG   1 
ATOM   1988 N ND1  . HIS A 1 136 ? 25.84600 -0.81200  12.64100  1.000 64.83000  ? 136 HIS A ND1  1 
ATOM   1989 C CD2  . HIS A 1 136 ? 24.46200 0.39800   11.49800  1.000 74.60000  ? 136 HIS A CD2  1 
ATOM   1990 C CE1  . HIS A 1 136 ? 26.56700 -0.00900  11.88100  1.000 80.07000  ? 136 HIS A CE1  1 
ATOM   1991 N NE2  . HIS A 1 136 ? 25.74500 0.72800   11.17400  1.000 70.83000  ? 136 HIS A NE2  1 
ATOM   1992 H H    . HIS A 1 136 ? 22.27500 -3.94100  12.79900  1.000 75.84000  ? 136 HIS A H    1 
ATOM   1993 H HA   . HIS A 1 136 ? 21.61300 -1.32400  12.25700  1.000 75.27000  ? 136 HIS A HA   1 
ATOM   1994 H HB2  . HIS A 1 136 ? 23.07500 -0.75100  13.80800  1.000 62.92000  ? 136 HIS A HB2  1 
ATOM   1995 H HB3  . HIS A 1 136 ? 23.92700 -2.06300  13.64000  1.000 62.92000  ? 136 HIS A HB3  1 
ATOM   1996 H HD2  . HIS A 1 136 ? 23.69200 0.77900   11.12300  1.000 89.40000  ? 136 HIS A HD2  1 
ATOM   1997 H HE1  . HIS A 1 136 ? 27.50700 0.02200   11.84500  1.000 95.96000  ? 136 HIS A HE1  1 
ATOM   1998 H HE2  . HIS A 1 136 ? 25.98300 1.33700   10.59400  1.000 84.87000  ? 136 HIS A HE2  1 
ATOM   1999 N N    . VAL A 1 137 ? 22.62300 -1.54100  9.93200   1.000 47.03000  ? 137 VAL A N    1 
ATOM   2000 C CA   . VAL A 1 137 ? 22.87300 -1.90300  8.51800   1.000 38.91000  ? 137 VAL A CA   1 
ATOM   2001 C C    . VAL A 1 137 ? 23.44300 -0.73500  7.72400   1.000 48.32000  ? 137 VAL A C    1 
ATOM   2002 O O    . VAL A 1 137 ? 22.94900 0.36500   7.89600   1.000 41.75000  ? 137 VAL A O    1 
ATOM   2003 C CB   . VAL A 1 137 ? 21.60800 -2.42100  7.80400   1.000 43.68000  ? 137 VAL A CB   1 
ATOM   2004 C CG1  . VAL A 1 137 ? 20.43800 -1.45100  7.88700   1.000 41.15000  ? 137 VAL A CG1  1 
ATOM   2005 C CG2  . VAL A 1 137 ? 21.87800 -2.80400  6.35600   1.000 38.11000  ? 137 VAL A CG2  1 
ATOM   2006 H H    . VAL A 1 137 ? 22.39700 -0.68200  10.08800  1.000 56.32000  ? 137 VAL A H    1 
ATOM   2007 H HA   . VAL A 1 137 ? 23.53500 -2.61700  8.50800   1.000 46.57000  ? 137 VAL A HA   1 
ATOM   2008 H HB   . VAL A 1 137 ? 21.33500 -3.24300  8.27200   1.000 52.30000  ? 137 VAL A HB   1 
ATOM   2009 H HG11 . VAL A 1 137 ? 19.62100 -1.90800  7.62200   1.000 49.25000  ? 137 VAL A HG11 1 
ATOM   2010 H HG12 . VAL A 1 137 ? 20.34300 -1.12500  8.79700   1.000 49.25000  ? 137 VAL A HG12 1 
ATOM   2011 H HG13 . VAL A 1 137 ? 20.59400 -0.70200  7.29000   1.000 49.25000  ? 137 VAL A HG13 1 
ATOM   2012 H HG21 . VAL A 1 137 ? 21.21200 -3.44900  6.06200   1.000 45.61000  ? 137 VAL A HG21 1 
ATOM   2013 H HG22 . VAL A 1 137 ? 21.83000 -2.01200  5.79400   1.000 45.61000  ? 137 VAL A HG22 1 
ATOM   2014 H HG23 . VAL A 1 137 ? 22.76200 -3.19900  6.28300   1.000 45.61000  ? 137 VAL A HG23 1 
ATOM   2015 N N    . GLN A 1 138 ? 24.50900 -0.96900  6.96900   1.000 43.86000  ? 138 GLN A N    1 
ATOM   2016 C CA   . GLN A 1 138 ? 24.98500 -0.04500  5.95600   1.000 36.24000  ? 138 GLN A CA   1 
ATOM   2017 C C    . GLN A 1 138 ? 24.66500 -0.61000  4.57900   1.000 48.48000  ? 138 GLN A C    1 
ATOM   2018 O O    . GLN A 1 138 ? 24.76500 -1.83200  4.33600   1.000 37.74000  ? 138 GLN A O    1 
ATOM   2019 C CB   . GLN A 1 138 ? 26.48300 0.16200   6.04600   1.000 39.96000  ? 138 GLN A CB   1 
ATOM   2020 C CG   . GLN A 1 138 ? 26.95700 0.75700   7.33600   1.000 69.22000  ? 138 GLN A CG   1 
ATOM   2021 C CD   . GLN A 1 138 ? 28.46000 0.83300   7.45900   1.000 63.50000  ? 138 GLN A CD   1 
ATOM   2022 O OE1  . GLN A 1 138 ? 29.22700 0.40100   6.57800   1.000 47.02000  ? 138 GLN A OE1  1 
ATOM   2023 N NE2  . GLN A 1 138 ? 28.89200 1.41400   8.57200   1.000 58.61000  ? 138 GLN A NE2  1 
ATOM   2024 H H    . GLN A 1 138 ? 24.97000 -1.69400  7.00900   1.000 52.50000  ? 138 GLN A H    1 
ATOM   2025 H HA   . GLN A 1 138 ? 24.54600 0.81100   6.07700   1.000 43.37000  ? 138 GLN A HA   1 
ATOM   2026 H HB2  . GLN A 1 138 ? 26.92000 -0.69900  5.94400   1.000 47.83000  ? 138 GLN A HB2  1 
ATOM   2027 H HB3  . GLN A 1 138 ? 26.75600 0.75900   5.33200   1.000 47.83000  ? 138 GLN A HB3  1 
ATOM   2028 H HG2  . GLN A 1 138 ? 26.60900 1.65900   7.40900   1.000 82.94000  ? 138 GLN A HG2  1 
ATOM   2029 H HG3  . GLN A 1 138 ? 26.62800 0.21400   8.06900   1.000 82.94000  ? 138 GLN A HG3  1 
ATOM   2030 H HE21 . GLN A 1 138 ? 28.32800 1.71000   9.15000   1.000 70.21000  ? 138 GLN A HE21 1 
ATOM   2031 H HE22 . GLN A 1 138 ? 29.73600 1.49500   8.71500   1.000 70.21000  ? 138 GLN A HE22 1 
ATOM   2032 N N    . VAL A 1 139 ? 24.21800 0.27000   3.69500   1.000 46.71000  ? 139 VAL A N    1 
ATOM   2033 C CA   . VAL A 1 139 ? 23.91300 -0.09500  2.32800   1.000 30.73000  ? 139 VAL A CA   1 
ATOM   2034 C C    . VAL A 1 139 ? 24.75200 0.80400   1.44100   1.000 43.68000  ? 139 VAL A C    1 
ATOM   2035 O O    . VAL A 1 139 ? 24.59800 2.02800   1.45500   1.000 40.71000  ? 139 VAL A O    1 
ATOM   2036 C CB   . VAL A 1 139 ? 22.41700 0.03600   1.99200   1.000 38.25000  ? 139 VAL A CB   1 
ATOM   2037 C CG1  . VAL A 1 139 ? 22.19900 -0.28500  0.46400   1.000 32.17000  ? 139 VAL A CG1  1 
ATOM   2038 C CG2  . VAL A 1 139 ? 21.60700 -0.86100  2.80600   1.000 42.09000  ? 139 VAL A CG2  1 
ATOM   2039 H H    . VAL A 1 139 ? 24.08100 1.10000   3.87100   1.000 55.93000  ? 139 VAL A H    1 
ATOM   2040 H HA   . VAL A 1 139 ? 24.15900 -1.02100  2.17700   1.000 36.75000  ? 139 VAL A HA   1 
ATOM   2041 H HB   . VAL A 1 139 ? 22.13200 0.94300   2.18300   1.000 45.77000  ? 139 VAL A HB   1 
ATOM   2042 H HG11 . VAL A 1 139 ? 21.25100 -0.24000  0.26500   1.000 38.48000  ? 139 VAL A HG11 1 
ATOM   2043 H HG12 . VAL A 1 139 ? 22.68100 0.36800   -0.06700  1.000 38.48000  ? 139 VAL A HG12 1 
ATOM   2044 H HG13 . VAL A 1 139 ? 22.53400 -1.17600  0.27800   1.000 38.48000  ? 139 VAL A HG13 1 
ATOM   2045 H HG21 . VAL A 1 139 ? 20.71200 -0.90200  2.43500   1.000 50.39000  ? 139 VAL A HG21 1 
ATOM   2046 H HG22 . VAL A 1 139 ? 22.00900 -1.74400  2.79800   1.000 50.39000  ? 139 VAL A HG22 1 
ATOM   2047 H HG23 . VAL A 1 139 ? 21.57400 -0.52100  3.71400   1.000 50.39000  ? 139 VAL A HG23 1 
ATOM   2048 N N    . ILE A 1 140 ? 25.59200 0.19400   0.63600   1.000 35.79000  ? 140 ILE A N    1 
ATOM   2049 C CA   . ILE A 1 140 ? 26.51200 0.87300   -0.25700  1.000 39.79000  ? 140 ILE A CA   1 
ATOM   2050 C C    . ILE A 1 140 ? 25.98600 0.63700   -1.64800  1.000 40.94000  ? 140 ILE A C    1 
ATOM   2051 O O    . ILE A 1 140 ? 25.79800 -0.53100  -2.04300  1.000 45.47000  ? 140 ILE A O    1 
ATOM   2052 C CB   . ILE A 1 140 ? 27.93100 0.27100   -0.11200  1.000 46.55000  ? 140 ILE A CB   1 
ATOM   2053 C CG1  . ILE A 1 140 ? 28.37700 0.41600   1.33200   1.000 41.14000  ? 140 ILE A CG1  1 
ATOM   2054 C CG2  . ILE A 1 140 ? 28.92700 0.82900   -1.09200  1.000 45.42000  ? 140 ILE A CG2  1 
ATOM   2055 C CD1  . ILE A 1 140 ? 29.23100 -0.66500  1.78600   1.000 54.02000  ? 140 ILE A CD1  1 
ATOM   2056 H H    . ILE A 1 140 ? 25.65400 -0.66300  0.58300   1.000 42.83000  ? 140 ILE A H    1 
ATOM   2057 H HA   . ILE A 1 140 ? 26.55100 1.82400   -0.07300  1.000 47.62000  ? 140 ILE A HA   1 
ATOM   2058 H HB   . ILE A 1 140 ? 27.88500 -0.67200  -0.33800  1.000 55.74000  ? 140 ILE A HB   1 
ATOM   2059 H HG12 . ILE A 1 140 ? 28.87300 1.24500   1.42400   1.000 49.25000  ? 140 ILE A HG12 1 
ATOM   2060 H HG13 . ILE A 1 140 ? 27.59200 0.43400   1.90200   1.000 49.25000  ? 140 ILE A HG13 1 
ATOM   2061 H HG21 . ILE A 1 140 ? 29.80300 0.46300   -0.89500  1.000 54.38000  ? 140 ILE A HG21 1 
ATOM   2062 H HG22 . ILE A 1 140 ? 28.65900 0.58000   -1.99100  1.000 54.38000  ? 140 ILE A HG22 1 
ATOM   2063 H HG23 . ILE A 1 140 ? 28.94500 1.79500   -1.00800  1.000 54.38000  ? 140 ILE A HG23 1 
ATOM   2064 H HD11 . ILE A 1 140 ? 29.59200 -0.43800  2.65700   1.000 64.69000  ? 140 ILE A HD11 1 
ATOM   2065 H HD12 . ILE A 1 140 ? 28.70500 -1.47800  1.84700   1.000 64.69000  ? 140 ILE A HD12 1 
ATOM   2066 H HD13 . ILE A 1 140 ? 29.95300 -0.78600  1.14900   1.000 64.69000  ? 140 ILE A HD13 1 
ATOM   2067 N N    . SER A 1 141 ? 25.80700 1.71100   -2.41400  1.000 42.69000  ? 141 SER A N    1 
ATOM   2068 C CA   . SER A 1 141 ? 25.25300 1.55700   -3.74600  1.000 47.97000  ? 141 SER A CA   1 
ATOM   2069 C C    . SER A 1 141 ? 25.89500 2.46200   -4.78600  1.000 47.56000  ? 141 SER A C    1 
ATOM   2070 O O    . SER A 1 141 ? 26.25400 3.61100   -4.51900  1.000 34.51000  ? 141 SER A O    1 
ATOM   2071 C CB   . SER A 1 141 ? 23.78700 1.83800   -3.66400  1.000 43.11000  ? 141 SER A CB   1 
ATOM   2072 O OG   . SER A 1 141 ? 23.08900 1.08300   -4.59100  1.000 44.16000  ? 141 SER A OG   1 
ATOM   2073 H H    . SER A 1 141 ? 25.99500 2.51800   -2.18500  1.000 51.11000  ? 141 SER A H    1 
ATOM   2074 H HA   . SER A 1 141 ? 25.44300 0.66100   -4.06800  1.000 57.44000  ? 141 SER A HA   1 
ATOM   2075 H HB2  . SER A 1 141 ? 23.47200 1.61500   -2.77400  1.000 51.61000  ? 141 SER A HB2  1 
ATOM   2076 H HB3  . SER A 1 141 ? 23.63500 2.77900   -3.84500  1.000 51.61000  ? 141 SER A HB3  1 
ATOM   2077 H HG   . SER A 1 141 ? 22.28600 1.32700   -4.61400  1.000 52.87000  ? 141 SER A HG   1 
ATOM   2078 N N    . LYS A 1 142 ? 26.05200 1.92300   -5.98300  1.000 43.50000  ? 142 LYS A N    1 
ATOM   2079 C CA   . LYS A 1 142 ? 26.59100 2.65000   -7.12900  1.000 51.73000  ? 142 LYS A CA   1 
ATOM   2080 C C    . LYS A 1 142 ? 25.70500 2.40100   -8.35600  1.000 45.66000  ? 142 LYS A C    1 
ATOM   2081 O O    . LYS A 1 142 ? 25.71100 1.30100   -8.94400  1.000 41.78000  ? 142 LYS A O    1 
ATOM   2082 C CB   . LYS A 1 142 ? 28.03600 2.22800   -7.41700  1.000 58.75000  ? 142 LYS A CB   1 
ATOM   2083 C CG   . LYS A 1 142 ? 28.61400 2.79600   -8.72800  1.000 48.19000  ? 142 LYS A CG   1 
ATOM   2084 C CD   . LYS A 1 142 ? 28.89200 4.35900   -8.63100  1.000 49.13000  ? 142 LYS A CD   1 
ATOM   2085 C CE   . LYS A 1 142 ? 29.50100 4.90000   -9.93900  1.000 59.98000  ? 142 LYS A CE   1 
ATOM   2086 N NZ   . LYS A 1 142 ? 28.90800 4.27100   -11.20400 1.000 82.09000  ? 142 LYS A NZ   1 
ATOM   2087 H H    . LYS A 1 142 ? 25.84800 1.10800   -6.16700  1.000 52.08000  ? 142 LYS A H    1 
ATOM   2088 H HA   . LYS A 1 142 ? 26.56700 3.59900   -6.93300  1.000 61.96000  ? 142 LYS A HA   1 
ATOM   2089 H HB2  . LYS A 1 142 ? 28.59900 2.53500   -6.69000  1.000 70.37000  ? 142 LYS A HB2  1 
ATOM   2090 H HB3  . LYS A 1 142 ? 28.07000 1.26000   -7.47600  1.000 70.37000  ? 142 LYS A HB3  1 
ATOM   2091 H HG2  . LYS A 1 142 ? 29.45300 2.35100   -8.92600  1.000 57.70000  ? 142 LYS A HG2  1 
ATOM   2092 H HG3  . LYS A 1 142 ? 27.98100 2.64600   -9.44800  1.000 57.70000  ? 142 LYS A HG3  1 
ATOM   2093 H HD2  . LYS A 1 142 ? 28.05700 4.82600   -8.46600  1.000 58.84000  ? 142 LYS A HD2  1 
ATOM   2094 H HD3  . LYS A 1 142 ? 29.51600 4.53100   -7.90900  1.000 58.84000  ? 142 LYS A HD3  1 
ATOM   2095 H HE2  . LYS A 1 142 ? 29.34600 5.85600   -9.98400  1.000 71.85000  ? 142 LYS A HE2  1 
ATOM   2096 H HE3  . LYS A 1 142 ? 30.45400 4.71900   -9.93800  1.000 71.85000  ? 142 LYS A HE3  1 
ATOM   2097 H HZ1  . LYS A 1 142 ? 29.29000 4.62300   -11.92700 1.000 98.38000  ? 142 LYS A HZ1  1 
ATOM   2098 H HZ2  . LYS A 1 142 ? 29.04800 3.39200   -11.20100 1.000 98.38000  ? 142 LYS A HZ2  1 
ATOM   2099 H HZ3  . LYS A 1 142 ? 28.03100 4.42300   -11.23700 1.000 98.38000  ? 142 LYS A HZ3  1 
ATOM   2100 N N    . HIS A 1 143 ? 24.96700 3.44300   -8.75500  1.000 57.54000  ? 143 HIS A N    1 
ATOM   2101 C CA   . HIS A 1 143 ? 24.20600 3.45900   -10.00200 1.000 65.05000  ? 143 HIS A CA   1 
ATOM   2102 C C    . HIS A 1 143 ? 25.08800 4.06200   -11.09200 1.000 47.09000  ? 143 HIS A C    1 
ATOM   2103 O O    . HIS A 1 143 ? 25.77400 5.05900   -10.85400 1.000 56.97000  ? 143 HIS A O    1 
ATOM   2104 C CB   . HIS A 1 143 ? 22.89700 4.27200   -9.86300  1.000 68.16000  ? 143 HIS A CB   1 
ATOM   2105 C CG   . HIS A 1 143 ? 21.97300 4.11600   -11.04200 1.000 77.51000  ? 143 HIS A CG   1 
ATOM   2106 N ND1  . HIS A 1 143 ? 22.25800 4.64600   -12.28500 1.000 73.04000  ? 143 HIS A ND1  1 
ATOM   2107 C CD2  . HIS A 1 143 ? 20.80800 3.44100   -11.17800 1.000 64.03000  ? 143 HIS A CD2  1 
ATOM   2108 C CE1  . HIS A 1 143 ? 21.30900 4.30000   -13.13300 1.000 73.27000  ? 143 HIS A CE1  1 
ATOM   2109 N NE2  . HIS A 1 143 ? 20.40800 3.58700   -12.48100 1.000 72.74000  ? 143 HIS A NE2  1 
ATOM   2110 H H    . HIS A 1 143 ? 24.89000 4.17200   -8.30500  1.000 68.92000  ? 143 HIS A H    1 
ATOM   2111 H HA   . HIS A 1 143 ? 23.94800 2.55600   -10.24800 1.000 77.94000  ? 143 HIS A HA   1 
ATOM   2112 H HB2  . HIS A 1 143 ? 22.42300 3.97300   -9.07200  1.000 81.67000  ? 143 HIS A HB2  1 
ATOM   2113 H HB3  . HIS A 1 143 ? 23.11900 5.21300   -9.78100  1.000 81.67000  ? 143 HIS A HB3  1 
ATOM   2114 H HD2  . HIS A 1 143 ? 20.36200 2.96800   -10.51200 1.000 76.71000  ? 143 HIS A HD2  1 
ATOM   2115 H HE1  . HIS A 1 143 ? 21.27900 4.52100   -14.03600 1.000 87.80000  ? 143 HIS A HE1  1 
ATOM   2116 H HE2  . HIS A 1 143 ? 19.68700 3.26500   -12.82000 1.000 87.17000  ? 143 HIS A HE2  1 
ATOM   2117 N N    . ASN A 1 144 ? 24.99800 3.51300   -12.30100 1.000 54.79000  ? 144 ASN A N    1 
ATOM   2118 C CA   . ASN A 1 144 ? 25.89800 3.88300   -13.39300 1.000 74.22000  ? 144 ASN A CA   1 
ATOM   2119 C C    . ASN A 1 144 ? 26.22200 5.37500   -13.48100 1.000 75.67000  ? 144 ASN A C    1 
ATOM   2120 O O    . ASN A 1 144 ? 27.39200 5.77300   -13.41700 1.000 109.59000 ? 144 ASN A O    1 
ATOM   2121 C CB   . ASN A 1 144 ? 25.31700 3.40400   -14.73500 1.000 39.37000  ? 144 ASN A CB   1 
ATOM   2122 C CG   . ASN A 1 144 ? 25.84700 2.04700   -15.11700 1.000 56.26000  ? 144 ASN A CG   1 
ATOM   2123 O OD1  . ASN A 1 144 ? 26.74800 1.54400   -14.44000 1.000 68.04000  ? 144 ASN A OD1  1 
ATOM   2124 N ND2  . ASN A 1 144 ? 25.33100 1.44700   -16.19900 1.000 53.12000  ? 144 ASN A ND2  1 
ATOM   2125 H H    . ASN A 1 144 ? 24.41700 2.91700   -12.51800 1.000 65.62000  ? 144 ASN A H    1 
ATOM   2126 H HA   . ASN A 1 144 ? 26.73500 3.42800   -13.21100 1.000 88.94000  ? 144 ASN A HA   1 
ATOM   2127 H HB2  . ASN A 1 144 ? 24.35100 3.34500   -14.66400 1.000 47.12000  ? 144 ASN A HB2  1 
ATOM   2128 H HB3  . ASN A 1 144 ? 25.56000 4.03400   -15.43200 1.000 47.12000  ? 144 ASN A HB3  1 
ATOM   2129 H HD21 . ASN A 1 144 ? 24.71500 1.83700   -16.65400 1.000 63.62000  ? 144 ASN A HD21 1 
ATOM   2130 H HD22 . ASN A 1 144 ? 25.61700 0.67200   -16.43800 1.000 63.62000  ? 144 ASN A HD22 1 
ATOM   2131 N N    . ASP A 1 145 ? 25.22900 6.22400   -13.66600 1.000 64.09000  ? 145 ASP A N    1 
ATOM   2132 C CA   . ASP A 1 145 ? 25.52900 7.61300   -14.02600 1.000 86.01000  ? 145 ASP A CA   1 
ATOM   2133 C C    . ASP A 1 145 ? 25.62800 8.51300   -12.79800 1.000 68.93000  ? 145 ASP A C    1 
ATOM   2134 O O    . ASP A 1 145 ? 25.45900 9.72900   -12.91300 1.000 79.22000  ? 145 ASP A O    1 
ATOM   2135 C CB   . ASP A 1 145 ? 24.47300 8.15400   -15.01500 1.000 100.01000 ? 145 ASP A CB   1 
ATOM   2136 C CG   . ASP A 1 145 ? 24.40300 7.33200   -16.33000 1.000 105.55000 ? 145 ASP A CG   1 
ATOM   2137 O OD1  . ASP A 1 145 ? 25.46800 7.00000   -16.91600 1.000 99.65000  ? 145 ASP A OD1  1 
ATOM   2138 O OD2  . ASP A 1 145 ? 23.26500 6.99200   -16.74800 1.000 116.46000 ? 145 ASP A OD2  1 
ATOM   2139 H H    . ASP A 1 145 ? 24.39400 6.03200   -13.59200 1.000 76.79000  ? 145 ASP A H    1 
ATOM   2140 H HA   . ASP A 1 145 ? 26.38400 7.63700   -14.48400 1.000 103.09000 ? 145 ASP A HA   1 
ATOM   2141 H HB2  . ASP A 1 145 ? 23.60000 8.12100   -14.59400 1.000 119.89000 ? 145 ASP A HB2  1 
ATOM   2142 H HB3  . ASP A 1 145 ? 24.69600 9.07000   -15.24500 1.000 119.89000 ? 145 ASP A HB3  1 
ATOM   2143 N N    . ASP A 1 146 ? 25.89700 7.93700   -11.63000 1.000 62.44000  ? 146 ASP A N    1 
ATOM   2144 C CA   . ASP A 1 146 ? 25.91800 8.66300   -10.36200 1.000 69.52000  ? 146 ASP A CA   1 
ATOM   2145 C C    . ASP A 1 146 ? 27.08400 8.15600   -9.52100  1.000 64.09000  ? 146 ASP A C    1 
ATOM   2146 O O    . ASP A 1 146 ? 27.78800 7.19900   -9.87900  1.000 47.47000  ? 146 ASP A O    1 
ATOM   2147 C CB   . ASP A 1 146 ? 24.59100 8.51000   -9.59900  1.000 58.69000  ? 146 ASP A CB   1 
ATOM   2148 C CG   . ASP A 1 146 ? 24.35900 9.58800   -8.55900  1.000 62.73000  ? 146 ASP A CG   1 
ATOM   2149 O OD1  . ASP A 1 146 ? 25.30600 10.28000  -8.13100  1.000 60.32000  ? 146 ASP A OD1  1 
ATOM   2150 O OD2  . ASP A 1 146 ? 23.17400 9.73600   -8.18500  1.000 70.60000  ? 146 ASP A OD2  1 
ATOM   2151 H H    A ASP A 1 146 ? 26.07700 7.10000   -11.54200 0.430 74.80000  ? 146 ASP A H    1 
ATOM   2152 H H    B ASP A 1 146 ? 26.07700 7.10000   -11.54200 0.570 74.80000  ? 146 ASP A H    1 
ATOM   2153 H HA   . ASP A 1 146 ? 26.05700 9.60700   -10.53700 1.000 83.30000  ? 146 ASP A HA   1 
ATOM   2154 H HB2  . ASP A 1 146 ? 23.85900 8.54900   -10.23400 1.000 70.30000  ? 146 ASP A HB2  1 
ATOM   2155 H HB3  . ASP A 1 146 ? 24.59000 7.65400   -9.14400  1.000 70.30000  ? 146 ASP A HB3  1 
ATOM   2156 N N    . GLU A 1 147 ? 27.30400 8.83500   -8.40800  1.000 47.69000  ? 147 GLU A N    1 
ATOM   2157 C CA   . GLU A 1 147 ? 28.40300 8.48300   -7.53100  1.000 52.03000  ? 147 GLU A CA   1 
ATOM   2158 C C    . GLU A 1 147 ? 28.01400 7.33400   -6.57400  1.000 65.94000  ? 147 GLU A C    1 
ATOM   2159 O O    . GLU A 1 147 ? 26.87600 6.84400   -6.56100  1.000 57.89000  ? 147 GLU A O    1 
ATOM   2160 C CB   . GLU A 1 147 ? 28.85100 9.70400   -6.71900  1.000 66.57000  ? 147 GLU A CB   1 
ATOM   2161 C CG   . GLU A 1 147 ? 29.11400 10.97300  -7.49700  1.000 85.28000  ? 147 GLU A CG   1 
ATOM   2162 C CD   . GLU A 1 147 ? 30.26500 10.84000  -8.49600  1.000 85.50000  ? 147 GLU A CD   1 
ATOM   2163 O OE1  . GLU A 1 147 ? 31.05900 9.88300   -8.35200  1.000 87.59000  ? 147 GLU A OE1  1 
ATOM   2164 O OE2  . GLU A 1 147 ? 30.37200 11.70100  -9.41600  1.000 89.15000  ? 147 GLU A OE2  1 
ATOM   2165 H H    . GLU A 1 147 ? 26.83200 9.50200   -8.13900  1.000 57.11000  ? 147 GLU A H    1 
ATOM   2166 H HA   . GLU A 1 147 ? 29.13400 8.18000   -8.09300  1.000 62.32000  ? 147 GLU A HA   1 
ATOM   2167 H HB2  . GLU A 1 147 ? 28.15700 9.90700   -6.07200  1.000 79.76000  ? 147 GLU A HB2  1 
ATOM   2168 H HB3  . GLU A 1 147 ? 29.67500 9.47600   -6.26100  1.000 79.76000  ? 147 GLU A HB3  1 
ATOM   2169 H HG2  . GLU A 1 147 ? 28.31500 11.20900  -7.99300  1.000 102.21000 ? 147 GLU A HG2  1 
ATOM   2170 H HG3  . GLU A 1 147 ? 29.34000 11.68200  -6.87500  1.000 102.21000 ? 147 GLU A HG3  1 
ATOM   2171 N N    . GLN A 1 148 ? 28.97000 6.91800   -5.72400  1.000 56.65000  ? 148 GLN A N    1 
ATOM   2172 C CA   . GLN A 1 148 ? 28.77600 5.79600   -4.81200  1.000 49.46000  ? 148 GLN A CA   1 
ATOM   2173 C C    . GLN A 1 148 ? 28.43800 6.36800   -3.45200  1.000 51.30000  ? 148 GLN A C    1 
ATOM   2174 O O    . GLN A 1 148 ? 29.17700 7.22300   -2.94800  1.000 43.17000  ? 148 GLN A O    1 
ATOM   2175 C CB   . GLN A 1 148 ? 30.01400 4.89100   -4.74100  1.000 54.24000  ? 148 GLN A CB   1 
ATOM   2176 C CG   . GLN A 1 148 ? 29.87200 3.68900   -3.83800  1.000 46.11000  ? 148 GLN A CG   1 
ATOM   2177 C CD   . GLN A 1 148 ? 31.00000 2.62000   -4.03700  1.000 32.56000  ? 148 GLN A CD   1 
ATOM   2178 O OE1  . GLN A 1 148 ? 31.29500 2.18500   -5.14600  1.000 48.35000  ? 148 GLN A OE1  1 
ATOM   2179 N NE2  . GLN A 1 148 ? 31.57000 2.16900   -2.94100  1.000 42.40000  ? 148 GLN A NE2  1 
ATOM   2180 H H    . GLN A 1 148 ? 29.74700 7.28100   -5.66300  1.000 67.86000  ? 148 GLN A H    1 
ATOM   2181 H HA   . GLN A 1 148 ? 28.04700 5.23200   -5.11800  1.000 59.23000  ? 148 GLN A HA   1 
ATOM   2182 H HB2  . GLN A 1 148 ? 30.20600 4.56400   -5.63400  1.000 64.97000  ? 148 GLN A HB2  1 
ATOM   2183 H HB3  . GLN A 1 148 ? 30.76000 5.41700   -4.41200  1.000 64.97000  ? 148 GLN A HB3  1 
ATOM   2184 H HG2  . GLN A 1 148 ? 29.90400 3.98500   -2.91500  1.000 55.21000  ? 148 GLN A HG2  1 
ATOM   2185 H HG3  . GLN A 1 148 ? 29.02100 3.26000   -4.01900  1.000 55.21000  ? 148 GLN A HG3  1 
ATOM   2186 H HE21 . GLN A 1 148 ? 31.31700 2.46300   -2.17300  1.000 50.76000  ? 148 GLN A HE21 1 
ATOM   2187 H HE22 . GLN A 1 148 ? 32.19500 1.58100   -2.99200  1.000 50.76000  ? 148 GLN A HE22 1 
ATOM   2188 N N    . TYR A 1 149 ? 27.34100 5.93200   -2.84800  1.000 46.26000  ? 149 TYR A N    1 
ATOM   2189 C CA   . TYR A 1 149 ? 26.88600 6.47500   -1.55100  1.000 50.40000  ? 149 TYR A CA   1 
ATOM   2190 C C    . TYR A 1 149 ? 26.74900 5.36500   -0.56300  1.000 43.08000  ? 149 TYR A C    1 
ATOM   2191 O O    . TYR A 1 149 ? 26.86100 4.22500   -0.92800  1.000 50.08000  ? 149 TYR A O    1 
ATOM   2192 C CB   . TYR A 1 149 ? 25.58300 7.23800   -1.76900  1.000 40.40000  ? 149 TYR A CB   1 
ATOM   2193 C CG   . TYR A 1 149 ? 25.73900 8.51700   -2.56500  1.000 55.97000  ? 149 TYR A CG   1 
ATOM   2194 C CD1  . TYR A 1 149 ? 25.73600 8.49700   -3.94800  1.000 52.95000  ? 149 TYR A CD1  1 
ATOM   2195 C CD2  . TYR A 1 149 ? 25.89200 9.73400   -1.92600  1.000 49.92000  ? 149 TYR A CD2  1 
ATOM   2196 C CE1  . TYR A 1 149 ? 25.88500 9.65600   -4.68200  1.000 56.64000  ? 149 TYR A CE1  1 
ATOM   2197 C CE2  . TYR A 1 149 ? 26.04300 10.90100  -2.64600  1.000 61.67000  ? 149 TYR A CE2  1 
ATOM   2198 C CZ   . TYR A 1 149 ? 26.03500 10.86200  -4.02700  1.000 60.04000  ? 149 TYR A CZ   1 
ATOM   2199 O OH   . TYR A 1 149 ? 26.17600 12.01400  -4.73400  1.000 75.05000  ? 149 TYR A OH   1 
ATOM   2200 H H    . TYR A 1 149 ? 26.82100 5.28000   -3.19500  1.000 55.39000  ? 149 TYR A H    1 
ATOM   2201 H HA   . TYR A 1 149 ? 27.56100 7.11100   -1.20700  1.000 60.36000  ? 149 TYR A HA   1 
ATOM   2202 H HB2  . TYR A 1 149 ? 24.95200 6.64700   -2.23600  1.000 48.36000  ? 149 TYR A HB2  1 
ATOM   2203 H HB3  . TYR A 1 149 ? 25.19900 7.45700   -0.89000  1.000 48.36000  ? 149 TYR A HB3  1 
ATOM   2204 H HD1  . TYR A 1 149 ? 25.63400 7.67400   -4.39800  1.000 63.41000  ? 149 TYR A HD1  1 
ATOM   2205 H HD2  . TYR A 1 149 ? 25.89800 9.76600   -0.98300  1.000 59.78000  ? 149 TYR A HD2  1 
ATOM   2206 H HE1  . TYR A 1 149 ? 25.88000 9.62600   -5.62200  1.000 67.85000  ? 149 TYR A HE1  1 
ATOM   2207 H HE2  . TYR A 1 149 ? 26.14400 11.72300  -2.19900  1.000 73.88000  ? 149 TYR A HE2  1 
ATOM   2208 H HH   . TYR A 1 149 ? 25.72300 12.63500  -4.35300  1.000 89.94000  ? 149 TYR A HH   1 
ATOM   2209 N N    . VAL A 1 150 ? 26.61300 5.72500   0.69700   1.000 52.82000  ? 150 VAL A N    1 
ATOM   2210 C CA   . VAL A 1 150 ? 26.44800 4.74100   1.78800   1.000 48.88000  ? 150 VAL A CA   1 
ATOM   2211 C C    . VAL A 1 150 ? 25.25700 5.21700   2.61500   1.000 53.98000  ? 150 VAL A C    1 
ATOM   2212 O O    . VAL A 1 150 ? 25.30500 6.33600   3.12800   1.000 54.16000  ? 150 VAL A O    1 
ATOM   2213 C CB   . VAL A 1 150 ? 27.70500 4.48600   2.64100   1.000 52.76000  ? 150 VAL A CB   1 
ATOM   2214 C CG1  . VAL A 1 150 ? 28.62700 5.69200   2.70300   1.000 55.96000  ? 150 VAL A CG1  1 
ATOM   2215 C CG2  . VAL A 1 150 ? 27.36800 3.95800   4.02800   1.000 50.88000  ? 150 VAL A CG2  1 
ATOM   2216 H H    . VAL A 1 150 ? 26.59000 6.59200   0.94300   1.000 63.26000  ? 150 VAL A H    1 
ATOM   2217 H HA   . VAL A 1 150 ? 26.20000 3.89600   1.38800   1.000 58.53000  ? 150 VAL A HA   1 
ATOM   2218 H HB   . VAL A 1 150 ? 28.21000 3.77300   2.18400   1.000 63.19000  ? 150 VAL A HB   1 
ATOM   2219 H HG11 . VAL A 1 150 ? 29.33700 5.52200   3.34300   1.000 67.03000  ? 150 VAL A HG11 1 
ATOM   2220 H HG12 . VAL A 1 150 ? 29.01500 5.85200   1.82500   1.000 67.03000  ? 150 VAL A HG12 1 
ATOM   2221 H HG13 . VAL A 1 150 ? 28.12200 6.47400   2.98000   1.000 67.03000  ? 150 VAL A HG13 1 
ATOM   2222 H HG21 . VAL A 1 150 ? 28.16400 3.56400   4.42400   1.000 60.93000  ? 150 VAL A HG21 1 
ATOM   2223 H HG22 . VAL A 1 150 ? 27.05700 4.68600   4.59100   1.000 60.93000  ? 150 VAL A HG22 1 
ATOM   2224 H HG23 . VAL A 1 150 ? 26.67500 3.28000   3.96000   1.000 60.93000  ? 150 VAL A HG23 1 
ATOM   2225 N N    . TRP A 1 151 ? 24.21000 4.41100   2.65200   1.000 50.90000  ? 151 TRP A N    1 
ATOM   2226 C CA   . TRP A 1 151 ? 23.00000 4.65300   3.44500   1.000 43.21000  ? 151 TRP A CA   1 
ATOM   2227 C C    . TRP A 1 151 ? 23.23100 3.96000   4.76200   1.000 50.27000  ? 151 TRP A C    1 
ATOM   2228 O O    . TRP A 1 151 ? 24.05100 3.09900   4.79100   1.000 53.33000  ? 151 TRP A O    1 
ATOM   2229 C CB   . TRP A 1 151 ? 21.84500 4.07000   2.63700   1.000 52.73000  ? 151 TRP A CB   1 
ATOM   2230 C CG   . TRP A 1 151 ? 20.46000 4.14500   3.20700   1.000 44.90000  ? 151 TRP A CG   1 
ATOM   2231 C CD1  . TRP A 1 151 ? 19.50500 5.07300   2.92800   1.000 40.43000  ? 151 TRP A CD1  1 
ATOM   2232 C CD2  . TRP A 1 151 ? 19.83900 3.16900   4.06400   1.000 55.98000  ? 151 TRP A CD2  1 
ATOM   2233 N NE1  . TRP A 1 151 ? 18.34700 4.77100   3.58800   1.000 52.80000  ? 151 TRP A NE1  1 
ATOM   2234 C CE2  . TRP A 1 151 ? 18.52000 3.60700   4.28700   1.000 58.62000  ? 151 TRP A CE2  1 
ATOM   2235 C CE3  . TRP A 1 151 ? 20.27500 1.99000   4.67100   1.000 41.57000  ? 151 TRP A CE3  1 
ATOM   2236 C CZ2  . TRP A 1 151 ? 17.63500 2.90200   5.09200   1.000 43.65000  ? 151 TRP A CZ2  1 
ATOM   2237 C CZ3  . TRP A 1 151 ? 19.39400 1.29400   5.46300   1.000 55.99000  ? 151 TRP A CZ3  1 
ATOM   2238 C CH2  . TRP A 1 151 ? 18.09200 1.74000   5.66300   1.000 47.60000  ? 151 TRP A CH2  1 
ATOM   2239 H H    . TRP A 1 151 ? 24.17400 3.67100   2.14600   1.000 60.95000  ? 151 TRP A H    1 
ATOM   2240 H HA   . TRP A 1 151 ? 22.87000 5.61800   3.57200   1.000 51.73000  ? 151 TRP A HA   1 
ATOM   2241 H HB2  . TRP A 1 151 ? 21.84000 4.51600   1.76300   1.000 63.16000  ? 151 TRP A HB2  1 
ATOM   2242 H HB3  . TRP A 1 151 ? 22.05100 3.12800   2.45600   1.000 63.16000  ? 151 TRP A HB3  1 
ATOM   2243 H HD1  . TRP A 1 151 ? 19.62500 5.83300   2.38000   1.000 48.39000  ? 151 TRP A HD1  1 
ATOM   2244 H HE1  . TRP A 1 151 ? 17.61300 5.24000   3.56400   1.000 63.24000  ? 151 TRP A HE1  1 
ATOM   2245 H HE3  . TRP A 1 151 ? 21.15600 1.68000   4.53900   1.000 49.76000  ? 151 TRP A HE3  1 
ATOM   2246 H HZ2  . TRP A 1 151 ? 16.75300 3.20000   5.22400   1.000 52.25000  ? 151 TRP A HZ2  1 
ATOM   2247 H HZ3  . TRP A 1 151 ? 19.67500 0.49500   5.87200   1.000 67.07000  ? 151 TRP A HZ3  1 
ATOM   2248 H HH2  . TRP A 1 151 ? 17.51400 1.24100   6.21200   1.000 57.00000  ? 151 TRP A HH2  1 
ATOM   2249 N N    . GLU A 1 152 ? 22.65500 4.41700   5.85000   1.000 55.88000  ? 152 GLU A N    1 
ATOM   2250 C CA   . GLU A 1 152 ? 22.95100 3.81400   7.16200   1.000 57.08000  ? 152 GLU A CA   1 
ATOM   2251 C C    . GLU A 1 152 ? 21.71900 3.98800   8.03000   1.000 54.52000  ? 152 GLU A C    1 
ATOM   2252 O O    . GLU A 1 152 ? 21.02700 4.94200   7.84600   1.000 50.50000  ? 152 GLU A O    1 
ATOM   2253 C CB   . GLU A 1 152 ? 24.18800 4.38600   7.83600   1.000 49.22000  ? 152 GLU A CB   1 
ATOM   2254 C CG   . GLU A 1 152 ? 24.85700 3.40300   8.78900   1.000 55.58000  ? 152 GLU A CG   1 
ATOM   2255 C CD   . GLU A 1 152 ? 26.24200 3.82100   9.23400   1.000 56.31000  ? 152 GLU A CD   1 
ATOM   2256 O OE1  . GLU A 1 152 ? 26.91400 4.57200   8.50600   1.000 65.02000  ? 152 GLU A OE1  1 
ATOM   2257 O OE2  . GLU A 1 152 ? 26.65600 3.39700   10.31900  1.000 44.00000  ? 152 GLU A OE2  1 
ATOM   2258 H H    . GLU A 1 152 ? 22.07600 5.10800   5.83100   1.000 66.94000  ? 152 GLU A H    1 
ATOM   2259 H HA   . GLU A 1 152 ? 23.09200 2.84600   7.03500   1.000 68.37000  ? 152 GLU A HA   1 
ATOM   2260 H HB2  . GLU A 1 152 ? 24.81700 4.65800   7.13800   1.000 58.94000  ? 152 GLU A HB2  1 
ATOM   2261 H HB3  . GLU A 1 152 ? 23.93000 5.18700   8.33500   1.000 58.94000  ? 152 GLU A HB3  1 
ATOM   2262 H HG2  . GLU A 1 152 ? 24.29300 3.29400   9.58400   1.000 66.57000  ? 152 GLU A HG2  1 
ATOM   2263 H HG3  . GLU A 1 152 ? 24.91800 2.52900   8.35100   1.000 66.57000  ? 152 GLU A HG3  1 
ATOM   2264 N N    . SER A 1 153 ? 21.39000 2.99000   8.85200   1.000 44.88000  ? 153 SER A N    1 
ATOM   2265 C CA   . SER A 1 153 ? 20.21700 3.02500   9.75400   1.000 66.54000  ? 153 SER A CA   1 
ATOM   2266 C C    . SER A 1 153 ? 20.43000 2.07600   10.93200  1.000 70.35000  ? 153 SER A C    1 
ATOM   2267 O O    . SER A 1 153 ? 20.96600 1.00700   10.71500  1.000 51.23000  ? 153 SER A O    1 
ATOM   2268 C CB   . SER A 1 153 ? 18.93700 2.67600   9.05400   1.000 67.38000  ? 153 SER A CB   1 
ATOM   2269 O OG   . SER A 1 153 ? 17.92600 2.32100   9.98500   1.000 65.63000  ? 153 SER A OG   1 
ATOM   2270 H H    . SER A 1 153 ? 21.87200 2.22900   8.90100   1.000 53.73000  ? 153 SER A H    1 
ATOM   2271 H HA   . SER A 1 153 ? 20.13300 3.94400   10.11400  1.000 79.72000  ? 153 SER A HA   1 
ATOM   2272 H HB2  . SER A 1 153 ? 18.63900 3.44100   8.52500   1.000 80.73000  ? 153 SER A HB2  1 
ATOM   2273 H HB3  . SER A 1 153 ? 19.09700 1.92900   8.44700   1.000 80.73000  ? 153 SER A HB3  1 
ATOM   2274 H HG   . SER A 1 153 ? 17.24000 2.06100   9.56300   1.000 78.63000  ? 153 SER A HG   1 
ATOM   2275 N N    . ASN A 1 154 ? 19.96500 2.46100   12.11700  1.000 80.26000  ? 154 ASN A N    1 
ATOM   2276 C CA   . ASN A 1 154 ? 20.08000 1.65000   13.35600  1.000 76.97000  ? 154 ASN A CA   1 
ATOM   2277 C C    . ASN A 1 154 ? 18.69300 1.13400   13.72500  1.000 89.93000  ? 154 ASN A C    1 
ATOM   2278 O O    . ASN A 1 154 ? 18.54800 0.66000   14.86100  1.000 84.74000  ? 154 ASN A O    1 
ATOM   2279 C CB   . ASN A 1 154 ? 20.65000 2.49100   14.48100  1.000 71.72000  ? 154 ASN A CB   1 
ATOM   2280 C CG   . ASN A 1 154 ? 19.71100 3.60800   14.86900  1.000 75.02000  ? 154 ASN A CG   1 
ATOM   2281 O OD1  . ASN A 1 154 ? 19.55800 4.58100   14.12300  1.000 66.02000  ? 154 ASN A OD1  1 
ATOM   2282 N ND2  . ASN A 1 154 ? 19.05300 3.47700   16.00900  1.000 69.76000  ? 154 ASN A ND2  1 
ATOM   2283 H H    . ASN A 1 154 ? 19.53800 3.24900   12.20800  1.000 96.19000  ? 154 ASN A H    1 
ATOM   2284 H HA   . ASN A 1 154 ? 20.68500 0.89100   13.20100  1.000 92.24000  ? 154 ASN A HA   1 
ATOM   2285 H HB2  . ASN A 1 154 ? 20.81900 1.92400   15.25900  1.000 85.94000  ? 154 ASN A HB2  1 
ATOM   2286 H HB3  . ASN A 1 154 ? 21.50200 2.87500   14.19300  1.000 85.94000  ? 154 ASN A HB3  1 
ATOM   2287 H HD21 . ASN A 1 154 ? 19.46900 3.16700   16.72700  1.000 83.59000  ? 154 ASN A HD21 1 
ATOM   2288 H HD22 . ASN A 1 154 ? 18.19300 3.69700   16.04800  1.000 83.59000  ? 154 ASN A HD22 1 
ATOM   2289 N N    . ALA A 1 155 ? 17.71600 1.26000   12.82700  1.000 90.58000  ? 155 ALA A N    1 
ATOM   2290 C CA   . ALA A 1 155 ? 16.32000 0.80200   13.02400  1.000 93.99000  ? 155 ALA A CA   1 
ATOM   2291 C C    . ALA A 1 155 ? 15.54400 1.82700   13.84300  1.000 95.24000  ? 155 ALA A C    1 
ATOM   2292 O O    . ALA A 1 155 ? 14.40100 1.49900   14.21100  1.000 99.34000  ? 155 ALA A O    1 
ATOM   2293 C CB   . ALA A 1 155 ? 16.26000 -0.56600  13.65300  1.000 75.90000  ? 155 ALA A CB   1 
ATOM   2294 H H    . ALA A 1 155 ? 17.84800 1.65100   12.02600  1.000 108.58000 ? 155 ALA A H    1 
ATOM   2295 H HA   . ALA A 1 155 ? 15.89400 0.75000   12.12500  1.000 112.67000 ? 155 ALA A HA   1 
ATOM   2296 H HB1  . ALA A 1 155 ? 15.46100 -1.02900  13.34800  1.000 90.95000  ? 155 ALA A HB1  1 
ATOM   2297 H HB2  . ALA A 1 155 ? 17.04200 -1.08300  13.39600  1.000 90.95000  ? 155 ALA A HB2  1 
ATOM   2298 H HB3  . ALA A 1 155 ? 16.23100 -0.48500  14.62000  1.000 90.95000  ? 155 ALA A HB3  1 
ATOM   2299 N N    . GLY A 1 156 ? 16.10400 3.01000   14.11300  1.000 89.21000  ? 156 GLY A N    1 
ATOM   2300 C CA   . GLY A 1 156 ? 15.40600 4.06600   14.81000  1.000 84.35000  ? 156 GLY A CA   1 
ATOM   2301 C C    . GLY A 1 156 ? 14.41500 4.75200   13.89900  1.000 81.28000  ? 156 GLY A C    1 
ATOM   2302 O O    . GLY A 1 156 ? 13.61300 4.09700   13.21500  1.000 89.74000  ? 156 GLY A O    1 
ATOM   2303 H H    . GLY A 1 156 ? 16.91900 3.20900   13.92400  1.000 106.93000 ? 156 GLY A H    1 
ATOM   2304 H HA2  . GLY A 1 156 ? 14.92900 3.69600   15.56900  1.000 101.10000 ? 156 GLY A HA2  1 
ATOM   2305 H HA3  . GLY A 1 156 ? 16.04400 4.72300   15.12900  1.000 101.10000 ? 156 GLY A HA3  1 
ATOM   2306 N N    . GLY A 1 157 ? 14.44700 6.07700   13.90800  1.000 71.25000  ? 157 GLY A N    1 
ATOM   2307 C CA   . GLY A 1 157 ? 13.59200 6.83600   13.02500  1.000 67.51000  ? 157 GLY A CA   1 
ATOM   2308 C C    . GLY A 1 157 ? 14.36200 7.72600   12.06800  1.000 71.42000  ? 157 GLY A C    1 
ATOM   2309 O O    . GLY A 1 157 ? 13.80200 8.63000   11.43800  1.000 91.86000  ? 157 GLY A O    1 
ATOM   2310 H H    . GLY A 1 157 ? 14.95400 6.55300   14.41400  1.000 85.38000  ? 157 GLY A H    1 
ATOM   2311 H HA2  . GLY A 1 157 ? 13.05200 6.22400   12.50100  1.000 80.89000  ? 157 GLY A HA2  1 
ATOM   2312 H HA3  . GLY A 1 157 ? 13.00600 7.39900   13.55500  1.000 80.89000  ? 157 GLY A HA3  1 
ATOM   2313 N N    . LYS A 1 158 ? 15.66200 7.48400   11.96000  1.000 68.14000  ? 158 LYS A N    1 
ATOM   2314 C CA   . LYS A 1 158 ? 16.55500 8.34200   11.20400  1.000 79.92000  ? 158 LYS A CA   1 
ATOM   2315 C C    . LYS A 1 158 ? 17.59400 7.48300   10.49500  1.000 70.70000  ? 158 LYS A C    1 
ATOM   2316 O O    . LYS A 1 158 ? 18.05400 6.46100   11.03400  1.000 75.25000  ? 158 LYS A O    1 
ATOM   2317 C CB   . LYS A 1 158 ? 17.21500 9.37700   12.12800  1.000 70.12000  ? 158 LYS A CB   1 
ATOM   2318 C CG   . LYS A 1 158 ? 18.00400 8.78800   13.30400  1.000 91.35000  ? 158 LYS A CG   1 
ATOM   2319 C CD   . LYS A 1 158 ? 17.16900 7.91600   14.22500  1.000 101.60000 ? 158 LYS A CD   1 
ATOM   2320 C CE   . LYS A 1 158 ? 17.92300 7.57500   15.51500  1.000 101.05000 ? 158 LYS A CE   1 
ATOM   2321 N NZ   . LYS A 1 158 ? 17.23100 6.49000   16.26600  1.000 90.68000  ? 158 LYS A NZ   1 
ATOM   2322 H H    . LYS A 1 158 ? 16.05700 6.81200   12.32400  1.000 81.64000  ? 158 LYS A H    1 
ATOM   2323 H HA   . LYS A 1 158 ? 16.07000 8.82400   10.51600  1.000 95.78000  ? 158 LYS A HA   1 
ATOM   2324 H HB2  . LYS A 1 158 ? 17.83300 9.90900   11.60100  1.000 84.01000  ? 158 LYS A HB2  1 
ATOM   2325 H HB3  . LYS A 1 158 ? 16.52100 9.94400   12.49900  1.000 84.01000  ? 158 LYS A HB3  1 
ATOM   2326 H HG2  . LYS A 1 158 ? 18.72600 8.24200   12.95500  1.000 109.49000 ? 158 LYS A HG2  1 
ATOM   2327 H HG3  . LYS A 1 158 ? 18.36500 9.51600   13.83400  1.000 109.49000 ? 158 LYS A HG3  1 
ATOM   2328 H HD2  . LYS A 1 158 ? 16.35500 8.38700   14.46300  1.000 121.80000 ? 158 LYS A HD2  1 
ATOM   2329 H HD3  . LYS A 1 158 ? 16.95100 7.08600   13.77100  1.000 121.80000 ? 158 LYS A HD3  1 
ATOM   2330 H HE2  . LYS A 1 158 ? 18.81900 7.27400   15.29600  1.000 121.13000 ? 158 LYS A HE2  1 
ATOM   2331 H HE3  . LYS A 1 158 ? 17.96600 8.36100   16.08200  1.000 121.13000 ? 158 LYS A HE3  1 
ATOM   2332 H HZ1  . LYS A 1 158 ? 17.64000 6.35000   17.04500  1.000 108.70000 ? 158 LYS A HZ1  1 
ATOM   2333 H HZ2  . LYS A 1 158 ? 16.38500 6.71800   16.42100  1.000 108.70000 ? 158 LYS A HZ2  1 
ATOM   2334 H HZ3  . LYS A 1 158 ? 17.24500 5.73600   15.79400  1.000 108.70000 ? 158 LYS A HZ3  1 
ATOM   2335 N N    . PHE A 1 159 ? 17.92400 7.88900   9.26300   1.000 63.43000  ? 159 PHE A N    1 
ATOM   2336 C CA   . PHE A 1 159 ? 18.95000 7.24000   8.46500   1.000 66.09000  ? 159 PHE A CA   1 
ATOM   2337 C C    . PHE A 1 159 ? 19.85000 8.32600   7.90200   1.000 53.74000  ? 159 PHE A C    1 
ATOM   2338 O O    . PHE A 1 159 ? 19.41200 9.46300   7.74300   1.000 61.91000  ? 159 PHE A O    1 
ATOM   2339 C CB   . PHE A 1 159 ? 18.38600 6.36600   7.29300   1.000 51.41000  ? 159 PHE A CB   1 
ATOM   2340 C CG   . PHE A 1 159 ? 17.56100 7.11000   6.30200   1.000 51.58000  ? 159 PHE A CG   1 
ATOM   2341 C CD1  . PHE A 1 159 ? 16.21400 7.34100   6.55000   1.000 47.01000  ? 159 PHE A CD1  1 
ATOM   2342 C CD2  . PHE A 1 159 ? 18.10600 7.54000   5.09700   1.000 56.03000  ? 159 PHE A CD2  1 
ATOM   2343 C CE1  . PHE A 1 159 ? 15.42900 8.02300   5.62400   1.000 57.04000  ? 159 PHE A CE1  1 
ATOM   2344 C CE2  . PHE A 1 159 ? 17.32800 8.24000   4.17400   1.000 58.18000  ? 159 PHE A CE2  1 
ATOM   2345 C CZ   . PHE A 1 159 ? 15.99300 8.48700   4.43900   1.000 51.83000  ? 159 PHE A CZ   1 
ATOM   2346 H H    . PHE A 1 159 ? 17.55300 8.55600   8.86600   1.000 75.99000  ? 159 PHE A H    1 
ATOM   2347 H HA   . PHE A 1 159 ? 19.45500 6.63700   9.03300   1.000 79.19000  ? 159 PHE A HA   1 
ATOM   2348 H HB2  . PHE A 1 159 ? 19.13300 5.97300   6.81500   1.000 61.57000  ? 159 PHE A HB2  1 
ATOM   2349 H HB3  . PHE A 1 159 ? 17.83000 5.66700   7.67100   1.000 61.57000  ? 159 PHE A HB3  1 
ATOM   2350 H HD1  . PHE A 1 159 ? 15.83300 7.03700   7.34200   1.000 56.29000  ? 159 PHE A HD1  1 
ATOM   2351 H HD2  . PHE A 1 159 ? 18.99700 7.36000   4.90500   1.000 67.11000  ? 159 PHE A HD2  1 
ATOM   2352 H HE1  . PHE A 1 159 ? 14.52700 8.16900   5.79700   1.000 68.33000  ? 159 PHE A HE1  1 
ATOM   2353 H HE2  . PHE A 1 159 ? 17.70700 8.54000   3.37900   1.000 69.69000  ? 159 PHE A HE2  1 
ATOM   2354 H HZ   . PHE A 1 159 ? 15.47600 8.96100   3.82900   1.000 62.07000  ? 159 PHE A HZ   1 
ATOM   2355 N N    . THR A 1 160 ? 21.06500 7.98100   7.48000   1.000 52.04000  ? 160 THR A N    1 
ATOM   2356 C CA   . THR A 1 160 ? 22.00200 8.93300   6.86500   1.000 52.22000  ? 160 THR A CA   1 
ATOM   2357 C C    . THR A 1 160 ? 22.29600 8.54000   5.44700   1.000 45.44000  ? 160 THR A C    1 
ATOM   2358 O O    . THR A 1 160 ? 22.01100 7.41000   5.11400   1.000 60.59000  ? 160 THR A O    1 
ATOM   2359 C CB   . THR A 1 160 ? 23.27700 9.00200   7.69700   1.000 69.90000  ? 160 THR A CB   1 
ATOM   2360 O OG1  . THR A 1 160 ? 23.84300 7.69800   7.68500   1.000 80.11000  ? 160 THR A OG1  1 
ATOM   2361 C CG2  . THR A 1 160 ? 22.99400 9.46200   9.11400   1.000 64.77000  ? 160 THR A CG2  1 
ATOM   2362 H H    . THR A 1 160 ? 21.40500 7.14700   7.53000   1.000 62.33000  ? 160 THR A H    1 
ATOM   2363 H HA   . THR A 1 160 ? 21.59600 9.80700   6.86600   1.000 62.54000  ? 160 THR A HA   1 
ATOM   2364 H HB   . THR A 1 160 ? 23.90600 9.63500   7.27400   1.000 83.76000  ? 160 THR A HB   1 
ATOM   2365 H HG1  . THR A 1 160 ? 23.56700 7.26100   8.37600   1.000 96.01000  ? 160 THR A HG1  1 
ATOM   2366 H HG21 . THR A 1 160 ? 23.81700 9.77700   9.52300   1.000 77.61000  ? 160 THR A HG21 1 
ATOM   2367 H HG22 . THR A 1 160 ? 22.34500 10.18600  9.09300   1.000 77.61000  ? 160 THR A HG22 1 
ATOM   2368 H HG23 . THR A 1 160 ? 22.63700 8.72200   9.63200   1.000 77.61000  ? 160 THR A HG23 1 
ATOM   2369 N N    . VAL A 1 161 ? 22.75500 9.46900   4.62100   1.000 44.03000  ? 161 VAL A N    1 
ATOM   2370 C CA   . VAL A 1 161 ? 23.18700 9.18400   3.22600   1.000 53.62000  ? 161 VAL A CA   1 
ATOM   2371 C C    . VAL A 1 161 ? 24.43100 10.05100  2.99800   1.000 68.38000  ? 161 VAL A C    1 
ATOM   2372 O O    . VAL A 1 161 ? 24.26000 11.26200  2.88900   1.000 67.22000  ? 161 VAL A O    1 
ATOM   2373 C CB   . VAL A 1 161 ? 22.12500 9.40500   2.13400   1.000 55.38000  ? 161 VAL A CB   1 
ATOM   2374 C CG1  . VAL A 1 161 ? 22.72700 9.34900   0.73600   1.000 46.87000  ? 161 VAL A CG1  1 
ATOM   2375 C CG2  . VAL A 1 161 ? 20.97900 8.41200   2.24800   1.000 46.47000  ? 161 VAL A CG2  1 
ATOM   2376 H H    . VAL A 1 161 ? 22.83300 10.33000  4.87600   1.000 52.72000  ? 161 VAL A H    1 
ATOM   2377 H HA   . VAL A 1 161 ? 23.46400 8.25000   3.18300   1.000 64.23000  ? 161 VAL A HA   1 
ATOM   2378 H HB   . VAL A 1 161 ? 21.75400 10.30800  2.26800   1.000 66.33000  ? 161 VAL A HB   1 
ATOM   2379 H HG11 . VAL A 1 161 ? 23.44300 8.69100   0.71600   1.000 56.13000  ? 161 VAL A HG11 1 
ATOM   2380 H HG12 . VAL A 1 161 ? 22.03900 9.09500   0.09800   1.000 56.13000  ? 161 VAL A HG12 1 
ATOM   2381 H HG13 . VAL A 1 161 ? 23.08300 10.22200  0.49600   1.000 56.13000  ? 161 VAL A HG13 1 
ATOM   2382 H HG21 . VAL A 1 161 ? 21.33700 7.51400   2.34700   1.000 55.64000  ? 161 VAL A HG21 1 
ATOM   2383 H HG22 . VAL A 1 161 ? 20.43400 8.63000   3.02400   1.000 55.64000  ? 161 VAL A HG22 1 
ATOM   2384 H HG23 . VAL A 1 161 ? 20.43000 8.45400   1.44700   1.000 55.64000  ? 161 VAL A HG23 1 
ATOM   2385 N N    . THR A 1 162 ? 25.62100 9.45600   2.91700   1.000 68.21000  ? 162 THR A N    1 
ATOM   2386 C CA   . THR A 1 162 ? 26.90500 10.15900  2.77900   1.000 50.78000  ? 162 THR A CA   1 
ATOM   2387 C C    . THR A 1 162 ? 27.57500 9.73300   1.51300   1.000 54.34000  ? 162 THR A C    1 
ATOM   2388 O O    . THR A 1 162 ? 27.33300 8.65100   1.10000   1.000 54.23000  ? 162 THR A O    1 
ATOM   2389 C CB   . THR A 1 162 ? 27.75400 9.79200   3.98700   1.000 56.68000  ? 162 THR A CB   1 
ATOM   2390 O OG1  . THR A 1 162 ? 26.86800 9.78700   5.09900   1.000 55.98000  ? 162 THR A OG1  1 
ATOM   2391 C CG2  . THR A 1 162 ? 28.89400 10.76700  4.21000   1.000 56.52000  ? 162 THR A CG2  1 
ATOM   2392 H H    . THR A 1 162 ? 25.72500 8.56000   2.93500   1.000 81.73000  ? 162 THR A H    1 
ATOM   2393 H HA   . THR A 1 162 ? 26.75700 11.12600  2.76600   1.000 60.82000  ? 162 THR A HA   1 
ATOM   2394 H HB   . THR A 1 162 ? 28.12400 8.88600   3.85900   1.000 67.90000  ? 162 THR A HB   1 
ATOM   2395 H HG1  . THR A 1 162 ? 27.30100 9.55100   5.80600   1.000 67.06000  ? 162 THR A HG1  1 
ATOM   2396 H HG21 . THR A 1 162 ? 28.54500 11.58600  4.59300   1.000 67.70000  ? 162 THR A HG21 1 
ATOM   2397 H HG22 . THR A 1 162 ? 29.53800 10.37500  4.82200   1.000 67.70000  ? 162 THR A HG22 1 
ATOM   2398 H HG23 . THR A 1 162 ? 29.32900 10.96500  3.36500   1.000 67.70000  ? 162 THR A HG23 1 
ATOM   2399 N N    . LEU A 1 163 ? 28.40200 10.57100  0.90200   1.000 52.33000  ? 163 LEU A N    1 
ATOM   2400 C CA   . LEU A 1 163 ? 29.20100 10.13500  -0.26800  1.000 70.28000  ? 163 LEU A CA   1 
ATOM   2401 C C    . LEU A 1 163 ? 30.15100 9.05300   0.24800   1.000 56.38000  ? 163 LEU A C    1 
ATOM   2402 O O    . LEU A 1 163 ? 30.64200 9.20300   1.37200   1.000 42.10000  ? 163 LEU A O    1 
ATOM   2403 C CB   . LEU A 1 163 ? 29.93100 11.27600  -0.96700  1.000 70.50000  ? 163 LEU A CB   1 
ATOM   2404 C CG   . LEU A 1 163 ? 30.44300 10.97000  -2.37400  1.000 66.64000  ? 163 LEU A CG   1 
ATOM   2405 C CD1  . LEU A 1 163 ? 29.32300 10.82400  -3.37400  1.000 70.91000  ? 163 LEU A CD1  1 
ATOM   2406 C CD2  . LEU A 1 163 ? 31.38600 12.06800  -2.78500  1.000 64.85000  ? 163 LEU A CD2  1 
ATOM   2407 H H    . LEU A 1 163 ? 28.50600 11.42200  1.17900   1.000 62.67000  ? 163 LEU A H    1 
ATOM   2408 H HA   . LEU A 1 163 ? 28.58400 9.71100   -0.91600  1.000 84.21000  ? 163 LEU A HA   1 
ATOM   2409 H HB2  . LEU A 1 163 ? 29.31700 12.04400  -1.02100  1.000 84.48000  ? 163 LEU A HB2  1 
ATOM   2410 H HB3  . LEU A 1 163 ? 30.69800 11.53700  -0.40800  1.000 84.48000  ? 163 LEU A HB3  1 
ATOM   2411 H HG   . LEU A 1 163 ? 30.94800 10.11800  -2.34500  1.000 79.84000  ? 163 LEU A HG   1 
ATOM   2412 H HD11 . LEU A 1 163 ? 29.69200 10.78200  -4.27100  1.000 84.97000  ? 163 LEU A HD11 1 
ATOM   2413 H HD12 . LEU A 1 163 ? 28.82500 10.00900  -3.19000  1.000 84.97000  ? 163 LEU A HD12 1 
ATOM   2414 H HD13 . LEU A 1 163 ? 28.72900 11.58900  -3.30500  1.000 84.97000  ? 163 LEU A HD13 1 
ATOM   2415 H HD21 . LEU A 1 163 ? 31.55800 12.00700  -3.73900  1.000 77.70000  ? 163 LEU A HD21 1 
ATOM   2416 H HD22 . LEU A 1 163 ? 30.98500 12.93000  -2.58300  1.000 77.70000  ? 163 LEU A HD22 1 
ATOM   2417 H HD23 . LEU A 1 163 ? 32.22100 11.97700  -2.29700  1.000 77.70000  ? 163 LEU A HD23 1 
ATOM   2418 N N    . ASP A 1 164 ? 30.43700 8.03300   -0.54800  1.000 49.20000  ? 164 ASP A N    1 
ATOM   2419 C CA   . ASP A 1 164 ? 31.17800 6.84900   -0.06000  1.000 68.93000  ? 164 ASP A CA   1 
ATOM   2420 C C    . ASP A 1 164 ? 32.66200 7.12300   -0.28100  1.000 63.37000  ? 164 ASP A C    1 
ATOM   2421 O O    . ASP A 1 164 ? 33.16000 7.04700   -1.40700  1.000 44.11000  ? 164 ASP A O    1 
ATOM   2422 C CB   . ASP A 1 164 ? 30.74900 5.55700   -0.76100  1.000 44.99000  ? 164 ASP A CB   1 
ATOM   2423 C CG   . ASP A 1 164 ? 31.35800 4.31000   -0.15800  1.000 61.42000  ? 164 ASP A CG   1 
ATOM   2424 O OD1  . ASP A 1 164 ? 32.25300 4.40000   0.72100   1.000 57.24000  ? 164 ASP A OD1  1 
ATOM   2425 O OD2  . ASP A 1 164 ? 30.92900 3.21200   -0.59600  1.000 53.34000  ? 164 ASP A OD2  1 
ATOM   2426 H H    . ASP A 1 164 ? 30.19500 7.98400   -1.37100  1.000 58.92000  ? 164 ASP A H    1 
ATOM   2427 H HA   . ASP A 1 164 ? 30.99400 6.73800   0.88500   1.000 82.59000  ? 164 ASP A HA   1 
ATOM   2428 H HB2  . ASP A 1 164 ? 29.78400 5.47500   -0.70100  1.000 53.87000  ? 164 ASP A HB2  1 
ATOM   2429 H HB3  . ASP A 1 164 ? 31.02100 5.60000   -1.69100  1.000 53.87000  ? 164 ASP A HB3  1 
ATOM   2430 N N    . GLU A 1 165 ? 33.36100 7.44400   0.80900   1.000 49.33000  ? 165 GLU A N    1 
ATOM   2431 C CA   . GLU A 1 165 ? 34.80500 7.64900   0.81700   1.000 61.14000  ? 165 GLU A CA   1 
ATOM   2432 C C    . GLU A 1 165 ? 35.52600 6.67600   1.75200   1.000 57.30000  ? 165 GLU A C    1 
ATOM   2433 O O    . GLU A 1 165 ? 36.63100 6.97700   2.20900   1.000 85.72000  ? 165 GLU A O    1 
ATOM   2434 C CB   . GLU A 1 165 ? 35.08000 9.09800   1.22400   1.000 68.41000  ? 165 GLU A CB   1 
ATOM   2435 C CG   . GLU A 1 165 ? 34.26500 10.10400  0.42500   1.000 88.18000  ? 165 GLU A CG   1 
ATOM   2436 C CD   . GLU A 1 165 ? 34.76400 11.52600  0.55100   1.000 93.92000  ? 165 GLU A CD   1 
ATOM   2437 O OE1  . GLU A 1 165 ? 34.99700 11.96300  1.72300   1.000 67.10000  ? 165 GLU A OE1  1 
ATOM   2438 O OE2  . GLU A 1 165 ? 34.91200 12.16900  -0.52900  1.000 69.28000  ? 165 GLU A OE2  1 
ATOM   2439 H H    . GLU A 1 165 ? 33.00500 7.55300   1.58500   1.000 59.07000  ? 165 GLU A H    1 
ATOM   2440 H HA   . GLU A 1 165 ? 35.16600 7.49100   -0.07000  1.000 73.24000  ? 165 GLU A HA   1 
ATOM   2441 H HB2  . GLU A 1 165 ? 34.85800 9.20900   2.16100   1.000 81.97000  ? 165 GLU A HB2  1 
ATOM   2442 H HB3  . GLU A 1 165 ? 36.02000 9.29200   1.08000   1.000 81.97000  ? 165 GLU A HB3  1 
ATOM   2443 H HG2  . GLU A 1 165 ? 34.30000 9.86000   -0.51300  1.000 105.69000 ? 165 GLU A HG2  1 
ATOM   2444 H HG3  . GLU A 1 165 ? 33.34800 10.08300  0.74000   1.000 105.69000 ? 165 GLU A HG3  1 
ATOM   2445 N N    . THR A 1 166 ? 34.91600 5.52600   2.07000   1.000 52.58000  ? 166 THR A N    1 
ATOM   2446 C CA   . THR A 1 166 ? 35.57100 4.55400   2.92600   1.000 52.15000  ? 166 THR A CA   1 
ATOM   2447 C C    . THR A 1 166 ? 35.45700 3.07500   2.52200   1.000 60.40000  ? 166 THR A C    1 
ATOM   2448 O O    . THR A 1 166 ? 36.13500 2.23700   3.14200   1.000 49.20000  ? 166 THR A O    1 
ATOM   2449 C CB   . THR A 1 166 ? 35.06800 4.69900   4.37600   1.000 69.64000  ? 166 THR A CB   1 
ATOM   2450 O OG1  . THR A 1 166 ? 33.70500 4.29900   4.54100   1.000 58.45000  ? 166 THR A OG1  1 
ATOM   2451 C CG2  . THR A 1 166 ? 35.23200 6.13200   4.86100   1.000 62.45000  ? 166 THR A CG2  1 
ATOM   2452 H H    . THR A 1 166 ? 34.13200 5.29700   1.80200   1.000 62.97000  ? 166 THR A H    1 
ATOM   2453 H HA   . THR A 1 166 ? 36.51900 4.75800   2.89300   1.000 62.46000  ? 166 THR A HA   1 
ATOM   2454 H HB   . THR A 1 166 ? 35.60700 4.10500   4.92200   1.000 83.45000  ? 166 THR A HB   1 
ATOM   2455 H HG1  . THR A 1 166 ? 33.48900 4.34200   5.35200   1.000 70.02000  ? 166 THR A HG1  1 
ATOM   2456 H HG21 . THR A 1 166 ? 34.92600 6.21000   5.77800   1.000 74.82000  ? 166 THR A HG21 1 
ATOM   2457 H HG22 . THR A 1 166 ? 36.16600 6.39200   4.81800   1.000 74.82000  ? 166 THR A HG22 1 
ATOM   2458 H HG23 . THR A 1 166 ? 34.71300 6.73300   4.30300   1.000 74.82000  ? 166 THR A HG23 1 
ATOM   2459 N N    . ASN A 1 167 ? 34.70400 2.72600   1.48400   1.000 56.02000  ? 167 ASN A N    1 
ATOM   2460 C CA   . ASN A 1 167 ? 34.46300 1.33400   1.16000   1.000 34.16000  ? 167 ASN A CA   1 
ATOM   2461 C C    . ASN A 1 167 ? 35.01800 1.03400   -0.23500  1.000 49.08000  ? 167 ASN A C    1 
ATOM   2462 O O    . ASN A 1 167 ? 35.17800 1.91700   -1.06900  1.000 52.14000  ? 167 ASN A O    1 
ATOM   2463 C CB   . ASN A 1 167 ? 32.95900 0.96300   1.17500   1.000 39.55000  ? 167 ASN A CB   1 
ATOM   2464 C CG   . ASN A 1 167 ? 32.30000 1.09500   2.55300   1.000 41.70000  ? 167 ASN A CG   1 
ATOM   2465 O OD1  . ASN A 1 167 ? 32.55700 0.31000   3.46200   1.000 37.88000  ? 167 ASN A OD1  1 
ATOM   2466 N ND2  . ASN A 1 167 ? 31.43200 2.11200   2.69700   1.000 46.54000  ? 167 ASN A ND2  1 
ATOM   2467 H H    . ASN A 1 167 ? 34.32200 3.28500   0.95200   1.000 67.10000  ? 167 ASN A H    1 
ATOM   2468 H HA   . ASN A 1 167 ? 34.91200 0.78900   1.82500   1.000 40.87000  ? 167 ASN A HA   1 
ATOM   2469 H HB2  . ASN A 1 167 ? 32.48700 1.55100   0.56500   1.000 47.34000  ? 167 ASN A HB2  1 
ATOM   2470 H HB3  . ASN A 1 167 ? 32.86300 0.04200   0.88900   1.000 47.34000  ? 167 ASN A HB3  1 
ATOM   2471 H HD21 . ASN A 1 167 ? 31.03300 2.23300   3.44900   1.000 55.73000  ? 167 ASN A HD21 1 
ATOM   2472 H HD22 . ASN A 1 167 ? 31.27600 2.64100   2.03700   1.000 55.73000  ? 167 ASN A HD22 1 
ATOM   2473 N N    . GLU A 1 168 ? 35.30400 -0.24100  -0.48800  1.000 42.96000  ? 168 GLU A N    1 
ATOM   2474 C CA   . GLU A 1 168 ? 35.65800 -0.66900  -1.83500  1.000 60.29000  ? 168 GLU A CA   1 
ATOM   2475 C C    . GLU A 1 168 ? 34.66200 -0.16600  -2.86900  1.000 46.56000  ? 168 GLU A C    1 
ATOM   2476 O O    . GLU A 1 168 ? 33.47100 -0.09000  -2.61900  1.000 49.99000  ? 168 GLU A O    1 
ATOM   2477 C CB   . GLU A 1 168 ? 35.72900 -2.20100  -1.90400  1.000 40.44000  ? 168 GLU A CB   1 
ATOM   2478 C CG   . GLU A 1 168 ? 34.54100 -2.90000  -1.25500  1.000 69.70000  ? 168 GLU A CG   1 
ATOM   2479 C CD   . GLU A 1 168 ? 34.72100 -4.39100  -1.28800  1.000 86.78000  ? 168 GLU A CD   1 
ATOM   2480 O OE1  . GLU A 1 168 ? 35.66100 -4.86400  -2.00500  1.000 88.15000  ? 168 GLU A OE1  1 
ATOM   2481 O OE2  . GLU A 1 168 ? 33.93600 -5.08700  -0.60900  1.000 80.78000  ? 168 GLU A OE2  1 
ATOM   2482 H H    . GLU A 1 168 ? 35.30000 -0.87100  0.09800   1.000 51.43000  ? 168 GLU A H    1 
ATOM   2483 H HA   . GLU A 1 168 ? 36.52700 -0.29800  -2.05200  1.000 72.22000  ? 168 GLU A HA   1 
ATOM   2484 H HB2  . GLU A 1 168 ? 35.75900 -2.47000  -2.83600  1.000 48.41000  ? 168 GLU A HB2  1 
ATOM   2485 H HB3  . GLU A 1 168 ? 36.53300 -2.49700  -1.44800  1.000 48.41000  ? 168 GLU A HB3  1 
ATOM   2486 H HG2  . GLU A 1 168 ? 34.46400 -2.61800  -0.33000  1.000 83.52000  ? 168 GLU A HG2  1 
ATOM   2487 H HG3  . GLU A 1 168 ? 33.73000 -2.67700  -1.73800  1.000 83.52000  ? 168 GLU A HG3  1 
ATOM   2488 N N    . ARG A 1 169 ? 35.16400 0.14200   -4.05500  1.000 41.77000  ? 169 ARG A N    1 
ATOM   2489 C CA   . ARG A 1 169 ? 34.31500 0.50500   -5.17100  1.000 45.66000  ? 169 ARG A CA   1 
ATOM   2490 C C    . ARG A 1 169 ? 33.54600 -0.70100  -5.67600  1.000 46.48000  ? 169 ARG A C    1 
ATOM   2491 O O    . ARG A 1 169 ? 34.08500 -1.80200  -5.81700  1.000 55.67000  ? 169 ARG A O    1 
ATOM   2492 C CB   . ARG A 1 169 ? 35.14400 1.08700   -6.31200  1.000 44.00000  ? 169 ARG A CB   1 
ATOM   2493 C CG   . ARG A 1 169 ? 35.97600 2.29800   -5.94500  1.000 43.75000  ? 169 ARG A CG   1 
ATOM   2494 C CD   . ARG A 1 169 ? 35.10700 3.43000   -5.45900  1.000 46.23000  ? 169 ARG A CD   1 
ATOM   2495 N NE   . ARG A 1 169 ? 35.10900 3.50200   -4.00600  1.000 45.65000  ? 169 ARG A NE   1 
ATOM   2496 C CZ   . ARG A 1 169 ? 34.50000 4.43900   -3.28800  1.000 46.55000  ? 169 ARG A CZ   1 
ATOM   2497 N NH1  . ARG A 1 169 ? 33.85400 5.45500   -3.86200  1.000 56.43000  ? 169 ARG A NH1  1 
ATOM   2498 N NH2  . ARG A 1 169 ? 34.56300 4.37700   -1.95600  1.000 44.63000  ? 169 ARG A NH2  1 
ATOM   2499 H H    . ARG A 1 169 ? 36.00400 0.14800   -4.24000  1.000 50.00000  ? 169 ARG A H    1 
ATOM   2500 H HA   . ARG A 1 169 ? 33.68300 1.17700   -4.87300  1.000 54.67000  ? 169 ARG A HA   1 
ATOM   2501 H HB2  . ARG A 1 169 ? 35.75200 0.40100   -6.63000  1.000 52.68000  ? 169 ARG A HB2  1 
ATOM   2502 H HB3  . ARG A 1 169 ? 34.54100 1.35200   -7.02400  1.000 52.68000  ? 169 ARG A HB3  1 
ATOM   2503 H HG2  . ARG A 1 169 ? 36.59500 2.06200   -5.23700  1.000 52.37000  ? 169 ARG A HG2  1 
ATOM   2504 H HG3  . ARG A 1 169 ? 36.46500 2.60200   -6.72600  1.000 52.37000  ? 169 ARG A HG3  1 
ATOM   2505 H HD2  . ARG A 1 169 ? 35.44400 4.27000   -5.80800  1.000 55.35000  ? 169 ARG A HD2  1 
ATOM   2506 H HD3  . ARG A 1 169 ? 34.19500 3.28900   -5.75800  1.000 55.35000  ? 169 ARG A HD3  1 
ATOM   2507 H HE   . ARG A 1 169 ? 35.53700 2.89000   -3.57900  1.000 54.65000  ? 169 ARG A HE   1 
ATOM   2508 H HH11 . ARG A 1 169 ? 33.82300 5.51500   -4.72000  1.000 67.59000  ? 169 ARG A HH11 1 
ATOM   2509 H HH12 . ARG A 1 169 ? 33.46700 6.05000   -3.37600  1.000 67.59000  ? 169 ARG A HH12 1 
ATOM   2510 H HH21 . ARG A 1 169 ? 34.99300 3.73600   -1.57500  1.000 53.43000  ? 169 ARG A HH21 1 
ATOM   2511 H HH22 . ARG A 1 169 ? 34.17400 4.97600   -1.47800  1.000 53.43000  ? 169 ARG A HH22 1 
ATOM   2512 N N    . LEU A 1 170 ? 32.26600 -0.49500  -5.90900  1.000 44.73000  ? 170 LEU A N    1 
ATOM   2513 C CA   . LEU A 1 170 ? 31.40200 -1.57800  -6.36700  1.000 49.71000  ? 170 LEU A CA   1 
ATOM   2514 C C    . LEU A 1 170 ? 31.45500 -1.73100  -7.86800  1.000 39.10000  ? 170 LEU A C    1 
ATOM   2515 O O    . LEU A 1 170 ? 31.27900 -2.83300  -8.38000  1.000 49.49000  ? 170 LEU A O    1 
ATOM   2516 C CB   . LEU A 1 170 ? 29.95200 -1.33300  -5.93400  1.000 54.98000  ? 170 LEU A CB   1 
ATOM   2517 C CG   . LEU A 1 170 ? 29.75300 -1.29600  -4.42500  1.000 51.15000  ? 170 LEU A CG   1 
ATOM   2518 C CD1  . LEU A 1 170 ? 28.32200 -1.15100  -4.13200  1.000 47.74000  ? 170 LEU A CD1  1 
ATOM   2519 C CD2  . LEU A 1 170 ? 30.31100 -2.59100  -3.89400  1.000 37.07000  ? 170 LEU A CD2  1 
ATOM   2520 H H    . LEU A 1 170 ? 31.86800 0.26100   -5.81100  1.000 53.56000  ? 170 LEU A H    1 
ATOM   2521 H HA   . LEU A 1 170 ? 31.68700 -2.40900  -5.95500  1.000 59.53000  ? 170 LEU A HA   1 
ATOM   2522 H HB2  . LEU A 1 170 ? 29.66100 -0.47900  -6.29200  1.000 65.85000  ? 170 LEU A HB2  1 
ATOM   2523 H HB3  . LEU A 1 170 ? 29.39700 -2.04600  -6.28800  1.000 65.85000  ? 170 LEU A HB3  1 
ATOM   2524 H HG   . LEU A 1 170 ? 30.20300 -0.55000  -3.99800  1.000 61.26000  ? 170 LEU A HG   1 
ATOM   2525 H HD11 . LEU A 1 170 ? 28.19200 -1.18200  -3.17100  1.000 57.17000  ? 170 LEU A HD11 1 
ATOM   2526 H HD12 . LEU A 1 170 ? 28.01300 -0.30000  -4.48000  1.000 57.17000  ? 170 LEU A HD12 1 
ATOM   2527 H HD13 . LEU A 1 170 ? 27.83800 -1.87800  -4.55500  1.000 57.17000  ? 170 LEU A HD13 1 
ATOM   2528 H HD21 . LEU A 1 170 ? 29.94500 -2.75300  -3.01000  1.000 44.36000  ? 170 LEU A HD21 1 
ATOM   2529 H HD22 . LEU A 1 170 ? 30.06200 -3.31200  -4.49300  1.000 44.36000  ? 170 LEU A HD22 1 
ATOM   2530 H HD23 . LEU A 1 170 ? 31.27800 -2.52100  -3.84400  1.000 44.36000  ? 170 LEU A HD23 1 
ATOM   2531 N N    . GLY A 1 171 ? 31.74500 -0.65200  -8.58900  1.000 50.84000  ? 171 GLY A N    1 
ATOM   2532 C CA   . GLY A 1 171 ? 31.69800 -0.68600  -10.04300 1.000 53.30000  ? 171 GLY A CA   1 
ATOM   2533 C C    . GLY A 1 171 ? 30.27300 -0.35800  -10.42000 1.000 57.42000  ? 171 GLY A C    1 
ATOM   2534 O O    . GLY A 1 171 ? 29.94300 0.73500   -10.90000 1.000 62.67000  ? 171 GLY A O    1 
ATOM   2535 H H    . GLY A 1 171 ? 31.97100 0.10900   -8.25900  1.000 60.89000  ? 171 GLY A H    1 
ATOM   2536 H HA2  . GLY A 1 171 ? 32.30200 -0.03000  -10.42400 1.000 63.83000  ? 171 GLY A HA2  1 
ATOM   2537 H HA3  . GLY A 1 171 ? 31.93700 -1.56500  -10.37600 1.000 63.83000  ? 171 GLY A HA3  1 
ATOM   2538 N N    . ARG A 1 172 ? 29.39900 -1.31500  -10.14900 1.000 63.09000  ? 172 ARG A N    1 
ATOM   2539 C CA   . ARG A 1 172 ? 27.97800 -1.04900  -10.22000 1.000 49.61000  ? 172 ARG A CA   1 
ATOM   2540 C C    . ARG A 1 172 ? 27.24700 -1.98300  -9.28200  1.000 55.40000  ? 172 ARG A C    1 
ATOM   2541 O O    . ARG A 1 172 ? 27.50900 -3.19100  -9.28200  1.000 47.73000  ? 172 ARG A O    1 
ATOM   2542 C CB   . ARG A 1 172 ? 27.47200 -1.23900  -11.64100 1.000 57.62000  ? 172 ARG A CB   1 
ATOM   2543 C CG   . ARG A 1 172 ? 26.06200 -0.87100  -11.84300 1.000 43.95000  ? 172 ARG A CG   1 
ATOM   2544 C CD   . ARG A 1 172 ? 25.62000 -1.37100  -13.17400 1.000 33.58000  ? 172 ARG A CD   1 
ATOM   2545 N NE   . ARG A 1 172 ? 25.62100 -2.81600  -13.28700 1.000 48.30000  ? 172 ARG A NE   1 
ATOM   2546 C CZ   . ARG A 1 172 ? 26.52200 -3.50300  -13.97400 1.000 61.63000  ? 172 ARG A CZ   1 
ATOM   2547 N NH1  . ARG A 1 172 ? 27.52100 -2.90700  -14.62500 1.000 55.44000  ? 172 ARG A NH1  1 
ATOM   2548 N NH2  . ARG A 1 172 ? 26.43100 -4.81800  -13.99900 1.000 50.54000  ? 172 ARG A NH2  1 
ATOM   2549 H H    . ARG A 1 172 ? 29.60600 -2.11900  -9.92400  1.000 75.59000  ? 172 ARG A H    1 
ATOM   2550 H HA   . ARG A 1 172 ? 27.80300 -0.13800  -9.93700  1.000 59.41000  ? 172 ARG A HA   1 
ATOM   2551 H HB2  . ARG A 1 172 ? 28.00500 -0.68800  -12.23500 1.000 69.02000  ? 172 ARG A HB2  1 
ATOM   2552 H HB3  . ARG A 1 172 ? 27.56700 -2.17400  -11.88100 1.000 69.02000  ? 172 ARG A HB3  1 
ATOM   2553 H HG2  . ARG A 1 172 ? 25.51200 -1.27700  -11.15400 1.000 52.61000  ? 172 ARG A HG2  1 
ATOM   2554 H HG3  . ARG A 1 172 ? 25.96500 0.09400   -11.82000 1.000 52.61000  ? 172 ARG A HG3  1 
ATOM   2555 H HD2  . ARG A 1 172 ? 24.71500 -1.06300  -13.33900 1.000 40.18000  ? 172 ARG A HD2  1 
ATOM   2556 H HD3  . ARG A 1 172 ? 26.21800 -1.02200  -13.85300 1.000 40.18000  ? 172 ARG A HD3  1 
ATOM   2557 H HE   . ARG A 1 172 ? 24.99900 -3.25400  -12.88400 1.000 57.84000  ? 172 ARG A HE   1 
ATOM   2558 H HH11 . ARG A 1 172 ? 27.59500 -2.05000  -14.60800 1.000 66.40000  ? 172 ARG A HH11 1 
ATOM   2559 H HH12 . ARG A 1 172 ? 28.09200 -3.37900  -15.06300 1.000 66.40000  ? 172 ARG A HH12 1 
ATOM   2560 H HH21 . ARG A 1 172 ? 25.79500 -5.21300  -13.57500 1.000 60.53000  ? 172 ARG A HH21 1 
ATOM   2561 H HH22 . ARG A 1 172 ? 27.00600 -5.28100  -14.43900 1.000 60.53000  ? 172 ARG A HH22 1 
ATOM   2562 N N    . GLY A 1 173 ? 26.34000 -1.41300  -8.49300  1.000 38.44000  ? 173 GLY A N    1 
ATOM   2563 C CA   . GLY A 1 173 ? 25.38900 -2.21900  -7.79100  1.000 37.43000  ? 173 GLY A CA   1 
ATOM   2564 C C    . GLY A 1 173 ? 25.21100 -1.82200  -6.35600  1.000 35.54000  ? 173 GLY A C    1 
ATOM   2565 O O    . GLY A 1 173 ? 25.26100 -0.63400  -6.02500  1.000 39.73000  ? 173 GLY A O    1 
ATOM   2566 H H    . GLY A 1 173 ? 26.26600 -0.56600  -8.35800  1.000 46.00000  ? 173 GLY A H    1 
ATOM   2567 H HA2  . GLY A 1 173 ? 24.52700 -2.14900  -8.23100  1.000 44.80000  ? 173 GLY A HA2  1 
ATOM   2568 H HA3  . GLY A 1 173 ? 25.68000 -3.14400  -7.81300  1.000 44.80000  ? 173 GLY A HA3  1 
ATOM   2569 N N    . THR A 1 174 ? 25.00200 -2.83600  -5.50600  1.000 32.79000  ? 174 THR A N    1 
ATOM   2570 C CA   . THR A 1 174 ? 24.57700 -2.64300  -4.13000  1.000 38.15000  ? 174 THR A CA   1 
ATOM   2571 C C    . THR A 1 174 ? 25.23200 -3.69400  -3.21900  1.000 33.32000  ? 174 THR A C    1 
ATOM   2572 O O    . THR A 1 174 ? 25.32100 -4.89100  -3.54000  1.000 31.40000  ? 174 THR A O    1 
ATOM   2573 C CB   . THR A 1 174 ? 23.00300 -2.67200  -4.03600  1.000 41.23000  ? 174 THR A CB   1 
ATOM   2574 O OG1  . THR A 1 174 ? 22.42200 -1.67100  -4.90900  1.000 44.70000  ? 174 THR A OG1  1 
ATOM   2575 C CG2  . THR A 1 174 ? 22.58900 -2.41700  -2.60500  1.000 42.51000  ? 174 THR A CG2  1 
ATOM   2576 H H    . THR A 1 174 ? 25.10500 -3.66300  -5.71600  1.000 39.22000  ? 174 THR A H    1 
ATOM   2577 H HA   . THR A 1 174 ? 24.87800 -1.78300  -3.79700  1.000 45.65000  ? 174 THR A HA   1 
ATOM   2578 H HB   . THR A 1 174 ? 22.66700 -3.53800  -4.31500  1.000 49.35000  ? 174 THR A HB   1 
ATOM   2579 H HG1  . THR A 1 174 ? 22.71000 -0.90900  -4.70300  1.000 53.52000  ? 174 THR A HG1  1 
ATOM   2580 H HG21 . THR A 1 174 ? 21.63500 -2.25100  -2.56000  1.000 50.89000  ? 174 THR A HG21 1 
ATOM   2581 H HG22 . THR A 1 174 ? 22.80100 -3.18900  -2.05700  1.000 50.89000  ? 174 THR A HG22 1 
ATOM   2582 H HG23 . THR A 1 174 ? 23.06000 -1.64400  -2.25600  1.000 50.89000  ? 174 THR A HG23 1 
ATOM   2583 N N    . MET A 1 175 ? 25.64200 -3.25100  -2.04500  1.000 25.32000  ? 175 MET A N    1 
ATOM   2584 C CA   . MET A 1 175 ? 26.17000 -4.18300  -1.06300  1.000 33.72000  ? 175 MET A CA   1 
ATOM   2585 C C    . MET A 1 175 ? 25.54900 -3.82200  0.27700   1.000 38.87000  ? 175 MET A C    1 
ATOM   2586 O O    . MET A 1 175 ? 25.69400 -2.69500  0.72700   1.000 38.22000  ? 175 MET A O    1 
ATOM   2587 C CB   . MET A 1 175 ? 27.71800 -4.12900  -0.94700  1.000 38.51000  ? 175 MET A CB   1 
ATOM   2588 C CG   . MET A 1 175 ? 28.35100 -4.99300  0.20800   1.000 43.79000  ? 175 MET A CG   1 
ATOM   2589 S SD   . MET A 1 175 ? 30.14000 -5.45500  -0.05400  1.000 46.43000  ? 175 MET A SD   1 
ATOM   2590 C CE   . MET A 1 175 ? 30.86000 -4.03700  0.57900   1.000 43.61000  ? 175 MET A CE   1 
ATOM   2591 H H    . MET A 1 175 ? 25.62500 -2.42900  -1.79500  1.000 30.26000  ? 175 MET A H    1 
ATOM   2592 H HA   . MET A 1 175 ? 25.93400 -5.08400  -1.33400  1.000 40.34000  ? 175 MET A HA   1 
ATOM   2593 H HB2  . MET A 1 175 ? 28.09600 -4.44500  -1.78300  1.000 46.08000  ? 175 MET A HB2  1 
ATOM   2594 H HB3  . MET A 1 175 ? 27.97900 -3.20800  -0.79300  1.000 46.08000  ? 175 MET A HB3  1 
ATOM   2595 H HG2  . MET A 1 175 ? 28.29900 -4.48900  1.03500   1.000 52.43000  ? 175 MET A HG2  1 
ATOM   2596 H HG3  . MET A 1 175 ? 27.84600 -5.81800  0.29000   1.000 52.43000  ? 175 MET A HG3  1 
ATOM   2597 H HE1  . MET A 1 175 ? 31.82500 -4.12700  0.53800   1.000 52.21000  ? 175 MET A HE1  1 
ATOM   2598 H HE2  . MET A 1 175 ? 30.57600 -3.27500  0.05100   1.000 52.21000  ? 175 MET A HE2  1 
ATOM   2599 H HE3  . MET A 1 175 ? 30.57800 -3.92400  1.50100   1.000 52.21000  ? 175 MET A HE3  1 
ATOM   2600 N N    . LEU A 1 176 ? 24.86500 -4.75900  0.90000   1.000 28.26000  ? 176 LEU A N    1 
ATOM   2601 C CA   . LEU A 1 176 ? 24.34300 -4.60300  2.22900   1.000 27.57000  ? 176 LEU A CA   1 
ATOM   2602 C C    . LEU A 1 176 ? 25.35700 -5.17600  3.22200   1.000 46.99000  ? 176 LEU A C    1 
ATOM   2603 O O    . LEU A 1 176 ? 25.81300 -6.31000  3.07800   1.000 40.13000  ? 176 LEU A O    1 
ATOM   2604 C CB   . LEU A 1 176 ? 23.00400 -5.32900  2.32500   1.000 37.31000  ? 176 LEU A CB   1 
ATOM   2605 C CG   . LEU A 1 176 ? 21.83200 -4.64300  1.62000   1.000 46.31000  ? 176 LEU A CG   1 
ATOM   2606 C CD1  . LEU A 1 176 ? 21.83400 -4.91000  0.11100   1.000 41.83000  ? 176 LEU A CD1  1 
ATOM   2607 C CD2  . LEU A 1 176 ? 20.47000 -5.08200  2.25900   1.000 37.47000  ? 176 LEU A CD2  1 
ATOM   2608 H H    . LEU A 1 176 ? 24.68400 -5.52500  0.55400   1.000 33.79000  ? 176 LEU A H    1 
ATOM   2609 H HA   . LEU A 1 176 ? 24.20500 -3.66900  2.45200   1.000 32.96000  ? 176 LEU A HA   1 
ATOM   2610 H HB2  . LEU A 1 176 ? 23.10500 -6.20900  1.93000   1.000 44.65000  ? 176 LEU A HB2  1 
ATOM   2611 H HB3  . LEU A 1 176 ? 22.76900 -5.41200  3.26300   1.000 44.65000  ? 176 LEU A HB3  1 
ATOM   2612 H HG   . LEU A 1 176 ? 21.93200 -3.68500  1.73700   1.000 55.44000  ? 176 LEU A HG   1 
ATOM   2613 H HD11 . LEU A 1 176 ? 21.02100 -4.54700  -0.27500  1.000 50.08000  ? 176 LEU A HD11 1 
ATOM   2614 H HD12 . LEU A 1 176 ? 22.60900 -4.48100  -0.28500  1.000 50.08000  ? 176 LEU A HD12 1 
ATOM   2615 H HD13 . LEU A 1 176 ? 21.87300 -5.86700  -0.04100  1.000 50.08000  ? 176 LEU A HD13 1 
ATOM   2616 H HD21 . LEU A 1 176 ? 19.74300 -4.77200  1.69700   1.000 44.84000  ? 176 LEU A HD21 1 
ATOM   2617 H HD22 . LEU A 1 176 ? 20.44900 -6.04900  2.32400   1.000 44.84000  ? 176 LEU A HD22 1 
ATOM   2618 H HD23 . LEU A 1 176 ? 20.39500 -4.69000  3.14300   1.000 44.84000  ? 176 LEU A HD23 1 
ATOM   2619 N N    . ARG A 1 177 ? 25.74600 -4.36100  4.17500   1.000 36.11000  ? 177 ARG A N    1 
ATOM   2620 C CA   A ARG A 1 177 ? 26.60200 -4.74200  5.28300   0.510 44.21000  ? 177 ARG A CA   1 
ATOM   2621 C CA   B ARG A 1 177 ? 26.60600 -4.74000  5.28400   0.490 47.16000  ? 177 ARG A CA   1 
ATOM   2622 C C    . ARG A 1 177 ? 25.67400 -4.94100  6.47000   1.000 36.78000  ? 177 ARG A C    1 
ATOM   2623 O O    . ARG A 1 177 ? 25.13300 -3.98300  7.02300   1.000 35.90000  ? 177 ARG A O    1 
ATOM   2624 C CB   A ARG A 1 177 ? 27.63900 -3.65600  5.53300   0.510 41.57000  ? 177 ARG A CB   1 
ATOM   2625 C CB   B ARG A 1 177 ? 27.65100 -3.65500  5.53400   0.490 40.46000  ? 177 ARG A CB   1 
ATOM   2626 C CG   A ARG A 1 177 ? 28.41300 -3.24100  4.28700   0.510 42.45000  ? 177 ARG A CG   1 
ATOM   2627 C CG   B ARG A 1 177 ? 28.88100 -4.14100  6.31200   0.490 40.99000  ? 177 ARG A CG   1 
ATOM   2628 C CD   A ARG A 1 177 ? 29.71600 -2.56700  4.70000   0.510 40.73000  ? 177 ARG A CD   1 
ATOM   2629 C CD   B ARG A 1 177 ? 30.03200 -3.13400  6.34400   0.490 33.88000  ? 177 ARG A CD   1 
ATOM   2630 N NE   A ARG A 1 177 ? 30.64800 -3.52100  5.28900   0.510 35.72000  ? 177 ARG A NE   1 
ATOM   2631 N NE   B ARG A 1 177 ? 30.73600 -3.06200  5.06800   0.490 34.78000  ? 177 ARG A NE   1 
ATOM   2632 C CZ   A ARG A 1 177 ? 31.19700 -3.41700  6.49300   0.510 34.13000  ? 177 ARG A CZ   1 
ATOM   2633 C CZ   B ARG A 1 177 ? 31.37000 -1.98800  4.61000   0.490 53.89000  ? 177 ARG A CZ   1 
ATOM   2634 N NH1  A ARG A 1 177 ? 30.99600 -2.35900  7.25900   0.510 36.71000  ? 177 ARG A NH1  1 
ATOM   2635 N NH1  B ARG A 1 177 ? 31.37200 -0.84000  5.29300   0.490 45.99000  ? 177 ARG A NH1  1 
ATOM   2636 N NH2  A ARG A 1 177 ? 31.98500 -4.39400  6.92800   0.510 43.02000  ? 177 ARG A NH2  1 
ATOM   2637 N NH2  B ARG A 1 177 ? 32.03900 -2.07300  3.45100   0.490 39.81000  ? 177 ARG A NH2  1 
ATOM   2638 H H    A ARG A 1 177 ? 25.51700 -3.53300  4.20800   0.510 43.20000  ? 177 ARG A H    1 
ATOM   2639 H H    B ARG A 1 177 ? 25.51500 -3.53300  4.20800   0.490 43.20000  ? 177 ARG A H    1 
ATOM   2640 H HA   A ARG A 1 177 ? 27.07600 -5.56900  5.10500   0.510 52.93000  ? 177 ARG A HA   1 
ATOM   2641 H HA   B ARG A 1 177 ? 27.08300 -5.56600  5.10800   0.490 56.47000  ? 177 ARG A HA   1 
ATOM   2642 H HB2  A ARG A 1 177 ? 27.18800 -2.86900  5.87700   0.510 49.77000  ? 177 ARG A HB2  1 
ATOM   2643 H HB2  B ARG A 1 177 ? 27.95800 -3.31700  4.67800   0.490 48.42000  ? 177 ARG A HB2  1 
ATOM   2644 H HB3  A ARG A 1 177 ? 28.28000 -3.98200  6.18400   0.510 49.77000  ? 177 ARG A HB3  1 
ATOM   2645 H HB3  B ARG A 1 177 ? 27.24200 -2.94000  6.04600   0.490 48.42000  ? 177 ARG A HB3  1 
ATOM   2646 H HG2  A ARG A 1 177 ? 28.62000 -4.02300  3.75200   0.510 50.82000  ? 177 ARG A HG2  1 
ATOM   2647 H HG2  B ARG A 1 177 ? 28.62000 -4.32000  7.22900   0.490 49.06000  ? 177 ARG A HG2  1 
ATOM   2648 H HG3  A ARG A 1 177 ? 27.88700 -2.61300  3.76600   0.510 50.82000  ? 177 ARG A HG3  1 
ATOM   2649 H HG3  B ARG A 1 177 ? 29.21200 -4.95300  5.89700   0.490 49.06000  ? 177 ARG A HG3  1 
ATOM   2650 H HD2  A ARG A 1 177 ? 30.13600 -2.17300  3.92000   0.510 48.75000  ? 177 ARG A HD2  1 
ATOM   2651 H HD2  B ARG A 1 177 ? 29.67800 -2.25400  6.54400   0.490 40.53000  ? 177 ARG A HD2  1 
ATOM   2652 H HD3  A ARG A 1 177 ? 29.52800 -1.87900  5.35800   0.510 48.75000  ? 177 ARG A HD3  1 
ATOM   2653 H HD3  B ARG A 1 177 ? 30.66800 -3.40000  7.02600   0.490 40.53000  ? 177 ARG A HD3  1 
ATOM   2654 H HE   A ARG A 1 177 ? 30.85900 -4.20900  4.81800   0.510 42.74000  ? 177 ARG A HE   1 
ATOM   2655 H HE   B ARG A 1 177 ? 30.74100 -3.76800  4.57600   0.490 41.62000  ? 177 ARG A HE   1 
ATOM   2656 H HH11 A ARG A 1 177 ? 30.49800 -1.71500  6.98100   0.510 43.93000  ? 177 ARG A HH11 1 
ATOM   2657 H HH11 B ARG A 1 177 ? 30.95800 -0.78600  6.04500   0.490 55.06000  ? 177 ARG A HH11 1 
ATOM   2658 H HH12 A ARG A 1 177 ? 31.36300 -2.31400  8.03600   0.510 43.93000  ? 177 ARG A HH12 1 
ATOM   2659 H HH12 B ARG A 1 177 ? 31.78800 -0.15500  4.98200   0.490 55.06000  ? 177 ARG A HH12 1 
ATOM   2660 H HH21 A ARG A 1 177 ? 32.13200 -5.08100  6.43200   0.510 51.50000  ? 177 ARG A HH21 1 
ATOM   2661 H HH21 B ARG A 1 177 ? 32.05200 -2.81500  3.01600   0.490 47.65000  ? 177 ARG A HH21 1 
ATOM   2662 H HH22 A ARG A 1 177 ? 32.34700 -4.34000  7.70600   0.510 51.50000  ? 177 ARG A HH22 1 
ATOM   2663 H HH22 B ARG A 1 177 ? 32.45400 -1.38600  3.14200   0.490 47.65000  ? 177 ARG A HH22 1 
ATOM   2664 N N    . LEU A 1 178 ? 25.42200 -6.18000  6.81400   1.000 39.21000  ? 178 LEU A N    1 
ATOM   2665 C CA   . LEU A 1 178 ? 24.56100 -6.47100  7.94600   1.000 42.35000  ? 178 LEU A CA   1 
ATOM   2666 C C    . LEU A 1 178 ? 25.40800 -6.61200  9.21200   1.000 42.86000  ? 178 LEU A C    1 
ATOM   2667 O O    . LEU A 1 178 ? 26.31000 -7.46300  9.26100   1.000 40.72000  ? 178 LEU A O    1 
ATOM   2668 C CB   . LEU A 1 178 ? 23.77700 -7.74400  7.68500   1.000 37.22000  ? 178 LEU A CB   1 
ATOM   2669 C CG   . LEU A 1 178 ? 22.74600 -7.82600  6.56000   1.000 53.20000  ? 178 LEU A CG   1 
ATOM   2670 C CD1  . LEU A 1 178 ? 21.92400 -9.10700  6.62800   1.000 46.78000  ? 178 LEU A CD1  1 
ATOM   2671 C CD2  . LEU A 1 178 ? 21.87400 -6.64400  6.66500   1.000 57.06000  ? 178 LEU A CD2  1 
ATOM   2672 H H    . LEU A 1 178 ? 25.73500 -6.87300  6.41200   1.000 46.93000  ? 178 LEU A H    1 
ATOM   2673 H HA   . LEU A 1 178 ? 23.93900 -5.73800  8.08100   1.000 50.70000  ? 178 LEU A HA   1 
ATOM   2674 H HB2  . LEU A 1 178 ? 24.42600 -8.44000  7.49900   1.000 44.54000  ? 178 LEU A HB2  1 
ATOM   2675 H HB3  . LEU A 1 178 ? 23.29500 -7.94900  8.50000   1.000 44.54000  ? 178 LEU A HB3  1 
ATOM   2676 H HG   . LEU A 1 178 ? 23.19700 -7.84300  5.70100   1.000 63.72000  ? 178 LEU A HG   1 
ATOM   2677 H HD11 . LEU A 1 178 ? 21.31500 -9.13200  5.87300   1.000 56.01000  ? 178 LEU A HD11 1 
ATOM   2678 H HD12 . LEU A 1 178 ? 22.52300 -9.87000  6.59400   1.000 56.01000  ? 178 LEU A HD12 1 
ATOM   2679 H HD13 . LEU A 1 178 ? 21.42200 -9.11700  7.45800   1.000 56.01000  ? 178 LEU A HD13 1 
ATOM   2680 H HD21 . LEU A 1 178 ? 21.07800 -6.79100  6.13000   1.000 68.35000  ? 178 LEU A HD21 1 
ATOM   2681 H HD22 . LEU A 1 178 ? 21.62900 -6.51400  7.59400   1.000 68.35000  ? 178 LEU A HD22 1 
ATOM   2682 H HD23 . LEU A 1 178 ? 22.35400 -5.86800  6.33700   1.000 68.35000  ? 178 LEU A HD23 1 
ATOM   2683 N N    . PHE A 1 179 ? 25.15000 -5.74800  10.20800  1.000 42.58000  ? 179 PHE A N    1 
ATOM   2684 C CA   . PHE A 1 179 ? 25.77400 -5.86500  11.53700  1.000 49.65000  ? 179 PHE A CA   1 
ATOM   2685 C C    . PHE A 1 179 ? 24.92000 -6.78500  12.39200  1.000 36.23000  ? 179 PHE A C    1 
ATOM   2686 O O    . PHE A 1 179 ? 23.98700 -6.36500  13.06800  1.000 57.46000  ? 179 PHE A O    1 
ATOM   2687 C CB   . PHE A 1 179 ? 25.95000 -4.48700  12.17500  1.000 36.57000  ? 179 PHE A CB   1 
ATOM   2688 C CG   . PHE A 1 179 ? 26.93100 -3.66200  11.44500  1.000 58.21000  ? 179 PHE A CG   1 
ATOM   2689 C CD1  . PHE A 1 179 ? 26.56400 -3.02400  10.25300  1.000 44.65000  ? 179 PHE A CD1  1 
ATOM   2690 C CD2  . PHE A 1 179 ? 28.23500 -3.56100  11.89600  1.000 39.48000  ? 179 PHE A CD2  1 
ATOM   2691 C CE1  . PHE A 1 179 ? 27.50700 -2.25700  9.54000   1.000 51.29000  ? 179 PHE A CE1  1 
ATOM   2692 C CE2  . PHE A 1 179 ? 29.18500 -2.80300  11.18300  1.000 30.26000  ? 179 PHE A CE2  1 
ATOM   2693 C CZ   . PHE A 1 179 ? 28.81000 -2.15500  10.00700  1.000 47.28000  ? 179 PHE A CZ   1 
ATOM   2694 H H    . PHE A 1 179 ? 24.61200 -5.08100  10.13800  1.000 50.97000  ? 179 PHE A H    1 
ATOM   2695 H HA   . PHE A 1 179 ? 26.65000 -6.27200  11.44300  1.000 59.45000  ? 179 PHE A HA   1 
ATOM   2696 H HB2  . PHE A 1 179 ? 25.09900 -4.02200  12.16900  1.000 43.76000  ? 179 PHE A HB2  1 
ATOM   2697 H HB3  . PHE A 1 179 ? 26.26300 -4.59500  13.08600  1.000 43.76000  ? 179 PHE A HB3  1 
ATOM   2698 H HD1  . PHE A 1 179 ? 25.69500 -3.10700  9.93100   1.000 53.45000  ? 179 PHE A HD1  1 
ATOM   2699 H HD2  . PHE A 1 179 ? 28.48700 -3.99800  12.67800  1.000 47.25000  ? 179 PHE A HD2  1 
ATOM   2700 H HE1  . PHE A 1 179 ? 27.25700 -1.82000  8.75800   1.000 61.43000  ? 179 PHE A HE1  1 
ATOM   2701 H HE2  . PHE A 1 179 ? 30.05800 -2.73600  11.49600  1.000 36.19000  ? 179 PHE A HE2  1 
ATOM   2702 H HZ   . PHE A 1 179 ? 29.43400 -1.65300  9.53400   1.000 56.61000  ? 179 PHE A HZ   1 
ATOM   2703 N N    . LEU A 1 180 ? 25.26000 -8.05900  12.35400  1.000 37.17000  ? 180 LEU A N    1 
ATOM   2704 C CA   . LEU A 1 180 ? 24.48700 -9.10600  12.99600  1.000 46.94000  ? 180 LEU A CA   1 
ATOM   2705 C C    . LEU A 1 180 ? 24.42300 -8.94100  14.51200  1.000 48.26000  ? 180 LEU A C    1 
ATOM   2706 O O    . LEU A 1 180 ? 25.29600 -8.34200  15.14500  1.000 55.62000  ? 180 LEU A O    1 
ATOM   2707 C CB   . LEU A 1 180 ? 25.09900 -10.45900 12.66400  1.000 53.44000  ? 180 LEU A CB   1 
ATOM   2708 C CG   . LEU A 1 180 ? 25.23900 -10.88400 11.20800  1.000 47.97000  ? 180 LEU A CG   1 
ATOM   2709 C CD1  . LEU A 1 180 ? 26.07500 -12.12800 11.10100  1.000 54.12000  ? 180 LEU A CD1  1 
ATOM   2710 C CD2  . LEU A 1 180 ? 23.88600 -11.15100 10.60900  1.000 50.85000  ? 180 LEU A CD2  1 
ATOM   2711 H H    . LEU A 1 180 ? 25.95900 -8.35700  11.95000  1.000 44.49000  ? 180 LEU A H    1 
ATOM   2712 H HA   . LEU A 1 180 ? 23.57500 -9.06200  12.66800  1.000 56.21000  ? 180 LEU A HA   1 
ATOM   2713 H HB2  . LEU A 1 180 ? 25.99400 -10.47000 13.03700  1.000 64.00000  ? 180 LEU A HB2  1 
ATOM   2714 H HB3  . LEU A 1 180 ? 24.55200 -11.13600 13.09300  1.000 64.00000  ? 180 LEU A HB3  1 
ATOM   2715 H HG   . LEU A 1 180 ? 25.67000 -10.16700 10.71700  1.000 57.44000  ? 180 LEU A HG   1 
ATOM   2716 H HD11 . LEU A 1 180 ? 26.13400 -12.39000 10.16900  1.000 64.82000  ? 180 LEU A HD11 1 
ATOM   2717 H HD12 . LEU A 1 180 ? 26.96100 -11.94300 11.45000  1.000 64.82000  ? 180 LEU A HD12 1 
ATOM   2718 H HD13 . LEU A 1 180 ? 25.65700 -12.83400 11.61800  1.000 64.82000  ? 180 LEU A HD13 1 
ATOM   2719 H HD21 . LEU A 1 180 ? 23.99600 -11.38800 9.67500   1.000 60.89000  ? 180 LEU A HD21 1 
ATOM   2720 H HD22 . LEU A 1 180 ? 23.46800 -11.88300 11.08900  1.000 60.89000  ? 180 LEU A HD22 1 
ATOM   2721 H HD23 . LEU A 1 180 ? 23.34300 -10.35200 10.68700  1.000 60.89000  ? 180 LEU A HD23 1 
ATOM   2722 N N    . LYS A 1 181 ? 23.38500 -9.53500  15.08900  1.000 76.57000  ? 181 LYS A N    1 
ATOM   2723 C CA   . LYS A 1 181 ? 23.19900 -9.55400  16.54700  1.000 48.27000  ? 181 LYS A CA   1 
ATOM   2724 C C    . LYS A 1 181 ? 24.01400 -10.74300 17.04200  1.000 55.18000  ? 181 LYS A C    1 
ATOM   2725 O O    . LYS A 1 181 ? 24.27300 -11.63500 16.23300  1.000 73.02000  ? 181 LYS A O    1 
ATOM   2726 C CB   . LYS A 1 181 ? 21.69900 -9.69000  16.79900  1.000 70.53000  ? 181 LYS A CB   1 
ATOM   2727 C CG   . LYS A 1 181 ? 20.74400 -8.74800  16.08600  1.000 55.95000  ? 181 LYS A CG   1 
ATOM   2728 C CD   . LYS A 1 181 ? 19.39300 -9.41500  15.87900  1.000 57.36000  ? 181 LYS A CD   1 
ATOM   2729 C CE   . LYS A 1 181 ? 18.36000 -8.46500  15.39500  1.000 66.54000  ? 181 LYS A CE   1 
ATOM   2730 N NZ   . LYS A 1 181 ? 17.01900 -8.86900  15.81800  1.000 58.62000  ? 181 LYS A NZ   1 
ATOM   2731 H H    . LYS A 1 181 ? 22.75300 -9.97800  14.62100  1.000 91.76000  ? 181 LYS A H    1 
ATOM   2732 H HA   . LYS A 1 181 ? 23.54500 -8.71500  16.94000  1.000 57.80000  ? 181 LYS A HA   1 
ATOM   2733 H HB2  . LYS A 1 181 ? 21.44400 -10.60700 16.55700  1.000 84.51000  ? 181 LYS A HB2  1 
ATOM   2734 H HB3  . LYS A 1 181 ? 21.54900 -9.59500  17.76300  1.000 84.51000  ? 181 LYS A HB3  1 
ATOM   2735 H HG2  . LYS A 1 181 ? 20.62900 -7.93600  16.62500  1.000 67.02000  ? 181 LYS A HG2  1 
ATOM   2736 H HG3  . LYS A 1 181 ? 21.11700 -8.49300  15.21600  1.000 67.02000  ? 181 LYS A HG3  1 
ATOM   2737 H HD2  . LYS A 1 181 ? 19.49300 -10.14100 15.22500  1.000 68.71000  ? 181 LYS A HD2  1 
ATOM   2738 H HD3  . LYS A 1 181 ? 19.09600 -9.80800  16.72600  1.000 68.71000  ? 181 LYS A HD3  1 
ATOM   2739 H HE2  . LYS A 1 181 ? 18.55000 -7.57200  15.73100  1.000 79.72000  ? 181 LYS A HE2  1 
ATOM   2740 H HE3  . LYS A 1 181 ? 18.39200 -8.43700  14.42400  1.000 79.72000  ? 181 LYS A HE3  1 
ATOM   2741 H HZ1  . LYS A 1 181 ? 16.84800 -9.70700  15.51800  1.000 70.22000  ? 181 LYS A HZ1  1 
ATOM   2742 H HZ2  . LYS A 1 181 ? 16.96800 -8.85500  16.72100  1.000 70.22000  ? 181 LYS A HZ2  1 
ATOM   2743 H HZ3  . LYS A 1 181 ? 16.40600 -8.29500  15.47200  1.000 70.22000  ? 181 LYS A HZ3  1 
ATOM   2744 N N    . GLU A 1 182 ? 24.38400 -10.77200 18.31200  1.000 69.19000  ? 182 GLU A N    1 
ATOM   2745 C CA   . GLU A 1 182 ? 25.25900 -11.83200 18.85800  1.000 48.16000  ? 182 GLU A CA   1 
ATOM   2746 C C    . GLU A 1 182 ? 24.58000 -13.19500 18.79600  1.000 63.07000  ? 182 GLU A C    1 
ATOM   2747 O O    . GLU A 1 182 ? 25.29700 -14.20100 18.81700  1.000 59.33000  ? 182 GLU A O    1 
ATOM   2748 C CB   . GLU A 1 182 ? 25.58600 -11.44300 20.29000  1.000 84.05000  ? 182 GLU A CB   1 
ATOM   2749 C CG   . GLU A 1 182 ? 26.93400 -10.74200 20.40100  1.000 99.24000  ? 182 GLU A CG   1 
ATOM   2750 C CD   . GLU A 1 182 ? 28.11000 -11.67200 20.62000  1.000 101.64000 ? 182 GLU A CD   1 
ATOM   2751 O OE1  . GLU A 1 182 ? 28.01800 -12.86600 20.28100  1.000 91.72000  ? 182 GLU A OE1  1 
ATOM   2752 O OE2  . GLU A 1 182 ? 29.12700 -11.18800 21.14400  1.000 104.05000 ? 182 GLU A OE2  1 
ATOM   2753 H H    . GLU A 1 182 ? 24.10800 -10.13900 18.89100  1.000 82.90000  ? 182 GLU A H    1 
ATOM   2754 H HA   . GLU A 1 182 ? 26.09300 -11.86100 18.32300  1.000 57.66000  ? 182 GLU A HA   1 
ATOM   2755 H HB2  . GLU A 1 182 ? 24.88600 -10.84900 20.62700  1.000 100.74000 ? 182 GLU A HB2  1 
ATOM   2756 H HB3  . GLU A 1 182 ? 25.58300 -12.24900 20.84500  1.000 100.74000 ? 182 GLU A HB3  1 
ATOM   2757 H HG2  . GLU A 1 182 ? 27.09300 -10.23200 19.57900  1.000 118.97000 ? 182 GLU A HG2  1 
ATOM   2758 H HG3  . GLU A 1 182 ? 26.90100 -10.10400 21.14300  1.000 118.97000 ? 182 GLU A HG3  1 
ATOM   2759 N N    . ASP A 1 183 ? 23.26200 -13.22200 18.71100  1.000 61.79000  ? 183 ASP A N    1 
ATOM   2760 C CA   . ASP A 1 183 ? 22.48200 -14.47700 18.66300  1.000 60.99000  ? 183 ASP A CA   1 
ATOM   2761 C C    . ASP A 1 183 ? 22.51200 -15.06800 17.26300  1.000 70.06000  ? 183 ASP A C    1 
ATOM   2762 O O    . ASP A 1 183 ? 22.38400 -16.29500 17.15800  1.000 66.77000  ? 183 ASP A O    1 
ATOM   2763 C CB   . ASP A 1 183 ? 21.05200 -14.17000 19.05600  1.000 77.13000  ? 183 ASP A CB   1 
ATOM   2764 C CG   . ASP A 1 183 ? 20.15200 -15.35600 19.35800  1.000 101.49000 ? 183 ASP A CG   1 
ATOM   2765 O OD1  . ASP A 1 183 ? 20.68200 -16.43100 19.70100  1.000 118.46000 ? 183 ASP A OD1  1 
ATOM   2766 O OD2  . ASP A 1 183 ? 18.92200 -15.18700 19.25800  1.000 117.07000 ? 183 ASP A OD2  1 
ATOM   2767 H H    . ASP A 1 183 ? 22.77300 -12.46500 18.69600  1.000 74.03000  ? 183 ASP A H    1 
ATOM   2768 H HA   . ASP A 1 183 ? 22.87400 -15.11600 19.29600  1.000 73.06000  ? 183 ASP A HA   1 
ATOM   2769 H HB2  . ASP A 1 183 ? 21.07100 -13.59200 19.84500  1.000 92.44000  ? 183 ASP A HB2  1 
ATOM   2770 H HB3  . ASP A 1 183 ? 20.64700 -13.66400 18.32200  1.000 92.44000  ? 183 ASP A HB3  1 
ATOM   2771 N N    . GLN A 1 184 ? 22.73400 -14.24900 16.24700  1.000 58.58000  ? 184 GLN A N    1 
ATOM   2772 C CA   . GLN A 1 184 ? 22.61000 -14.68300 14.84000  1.000 66.87000  ? 184 GLN A CA   1 
ATOM   2773 C C    . GLN A 1 184 ? 23.97000 -14.77500 14.14400  1.000 72.32000  ? 184 GLN A C    1 
ATOM   2774 O O    . GLN A 1 184 ? 24.00600 -14.62600 12.93200  1.000 65.99000  ? 184 GLN A O    1 
ATOM   2775 C CB   . GLN A 1 184 ? 21.68600 -13.64700 14.20200  1.000 66.56000  ? 184 GLN A CB   1 
ATOM   2776 C CG   . GLN A 1 184 ? 20.44200 -13.28200 15.00500  1.000 59.28000  ? 184 GLN A CG   1 
ATOM   2777 C CD   . GLN A 1 184 ? 19.47200 -14.42700 15.18100  1.000 66.33000  ? 184 GLN A CD   1 
ATOM   2778 O OE1  . GLN A 1 184 ? 19.39100 -15.34500 14.36300  1.000 63.09000  ? 184 GLN A OE1  1 
ATOM   2779 N NE2  . GLN A 1 184 ? 18.70800 -14.37100 16.25900  1.000 73.63000  ? 184 GLN A NE2  1 
ATOM   2780 H H    . GLN A 1 184 ? 22.97000 -13.38800 16.37900  1.000 70.18000  ? 184 GLN A H    1 
ATOM   2781 H HA   . GLN A 1 184 ? 22.17200 -15.56800 14.80700  1.000 80.13000  ? 184 GLN A HA   1 
ATOM   2782 H HB2  . GLN A 1 184 ? 22.20600 -12.83000 14.05200  1.000 79.75000  ? 184 GLN A HB2  1 
ATOM   2783 H HB3  . GLN A 1 184 ? 21.40600 -13.97900 13.32300  1.000 79.75000  ? 184 GLN A HB3  1 
ATOM   2784 H HG2  . GLN A 1 184 ? 20.70200 -12.94600 15.88800  1.000 71.02000  ? 184 GLN A HG2  1 
ATOM   2785 H HG3  . GLN A 1 184 ? 19.97400 -12.55600 14.54900  1.000 71.02000  ? 184 GLN A HG3  1 
ATOM   2786 H HE21 . GLN A 1 184 ? 18.90300 -13.79800 16.90600  1.000 88.24000  ? 184 GLN A HE21 1 
ATOM   2787 H HE22 . GLN A 1 184 ? 18.00300 -14.90300 16.33000  1.000 88.24000  ? 184 GLN A HE22 1 
ATOM   2788 N N    . LEU A 1 185 ? 25.04200 -15.02900 14.87800  1.000 61.95000  ? 185 LEU A N    1 
ATOM   2789 C CA   . LEU A 1 185 ? 26.40000 -15.07500 14.29200  1.000 50.86000  ? 185 LEU A CA   1 
ATOM   2790 C C    . LEU A 1 185 ? 26.59400 -16.42000 13.58500  1.000 58.39000  ? 185 LEU A C    1 
ATOM   2791 O O    . LEU A 1 185 ? 27.66400 -16.61200 13.01700  1.000 58.96000  ? 185 LEU A O    1 
ATOM   2792 C CB   . LEU A 1 185 ? 27.42100 -14.79100 15.38600  1.000 46.21000  ? 185 LEU A CB   1 
ATOM   2793 C CG   . LEU A 1 185 ? 27.39300 -13.37500 15.96600  1.000 65.02000  ? 185 LEU A CG   1 
ATOM   2794 C CD1  . LEU A 1 185 ? 28.45500 -13.22100 17.02000  1.000 60.75000  ? 185 LEU A CD1  1 
ATOM   2795 C CD2  . LEU A 1 185 ? 27.56500 -12.30700 14.90600  1.000 67.40000  ? 185 LEU A CD2  1 
ATOM   2796 H H    . LEU A 1 185 ? 24.98400 -15.17700 15.76500  1.000 74.21000  ? 185 LEU A H    1 
ATOM   2797 H HA   . LEU A 1 185 ? 26.46300 -14.36400 13.60600  1.000 60.91000  ? 185 LEU A HA   1 
ATOM   2798 H HB2  . LEU A 1 185 ? 27.27000 -15.42900 16.12000  1.000 55.33000  ? 185 LEU A HB2  1 
ATOM   2799 H HB3  . LEU A 1 185 ? 28.32000 -14.95300 15.01800  1.000 55.33000  ? 185 LEU A HB3  1 
ATOM   2800 H HG   . LEU A 1 185 ? 26.51200 -13.23700 16.39900  1.000 77.90000  ? 185 LEU A HG   1 
ATOM   2801 H HD11 . LEU A 1 185 ? 28.29500 -12.40500 17.52500  1.000 72.78000  ? 185 LEU A HD11 1 
ATOM   2802 H HD12 . LEU A 1 185 ? 28.42900 -13.98400 17.62000  1.000 72.78000  ? 185 LEU A HD12 1 
ATOM   2803 H HD13 . LEU A 1 185 ? 29.32700 -13.17100 16.59500  1.000 72.78000  ? 185 LEU A HD13 1 
ATOM   2804 H HD21 . LEU A 1 185 ? 28.02200 -11.54000 15.29100  1.000 80.76000  ? 185 LEU A HD21 1 
ATOM   2805 H HD22 . LEU A 1 185 ? 28.09200 -12.66200 14.17100  1.000 80.76000  ? 185 LEU A HD22 1 
ATOM   2806 H HD23 . LEU A 1 185 ? 26.69300 -12.03300 14.57600  1.000 80.76000  ? 185 LEU A HD23 1 
ATOM   2807 N N    . GLU A 1 186 ? 25.61500 -17.32600 13.63000  1.000 55.79000  ? 186 GLU A N    1 
ATOM   2808 C CA   . GLU A 1 186 ? 25.69100 -18.55500 12.85100  1.000 59.26000  ? 186 GLU A CA   1 
ATOM   2809 C C    . GLU A 1 186 ? 25.72100 -18.26900 11.34500  1.000 66.00000  ? 186 GLU A C    1 
ATOM   2810 O O    . GLU A 1 186 ? 26.22900 -19.08400 10.55700  1.000 62.06000  ? 186 GLU A O    1 
ATOM   2811 C CB   . GLU A 1 186 ? 24.51100 -19.45800 13.20600  1.000 57.36000  ? 186 GLU A CB   1 
ATOM   2812 C CG   . GLU A 1 186 ? 23.19200 -18.89000 12.82900  1.000 65.68000  ? 186 GLU A CG   1 
ATOM   2813 C CD   . GLU A 1 186 ? 22.01000 -19.64800 13.42400  1.000 75.09000  ? 186 GLU A CD   1 
ATOM   2814 O OE1  . GLU A 1 186 ? 21.71500 -19.42200 14.64600  1.000 72.42000  ? 186 GLU A OE1  1 
ATOM   2815 O OE2  . GLU A 1 186 ? 21.38600 -20.43800 12.63100  1.000 47.65000  ? 186 GLU A OE2  1 
ATOM   2816 H H    . GLU A 1 186 ? 24.92000 -17.24900 14.13000  1.000 66.82000  ? 186 GLU A H    1 
ATOM   2817 H HA   . GLU A 1 186 ? 26.51000 -19.02400 13.07500  1.000 70.98000  ? 186 GLU A HA   1 
ATOM   2818 H HB2  . GLU A 1 186 ? 24.61300 -20.30300 12.74100  1.000 68.71000  ? 186 GLU A HB2  1 
ATOM   2819 H HB3  . GLU A 1 186 ? 24.50700 -19.60500 14.16400  1.000 68.71000  ? 186 GLU A HB3  1 
ATOM   2820 H HG2  . GLU A 1 186 ? 23.14500 -17.97400 13.14300  1.000 78.69000  ? 186 GLU A HG2  1 
ATOM   2821 H HG3  . GLU A 1 186 ? 23.10500 -18.91600 11.86300  1.000 78.69000  ? 186 GLU A HG3  1 
ATOM   2822 N N    . TYR A 1 187 ? 25.15000 -17.14000 10.92100  1.000 49.88000  ? 187 TYR A N    1 
ATOM   2823 C CA   . TYR A 1 187 ? 25.05800 -16.78100 9.50800   1.000 55.34000  ? 187 TYR A CA   1 
ATOM   2824 C C    . TYR A 1 187 ? 26.39800 -16.27900 8.93100   1.000 62.68000  ? 187 TYR A C    1 
ATOM   2825 O O    . TYR A 1 187 ? 26.46300 -15.99900 7.74000   1.000 47.03000  ? 187 TYR A O    1 
ATOM   2826 C CB   . TYR A 1 187 ? 23.91600 -15.74700 9.32200   1.000 55.47000  ? 187 TYR A CB   1 
ATOM   2827 C CG   . TYR A 1 187 ? 22.57700 -16.30900 9.75100   1.000 47.89000  ? 187 TYR A CG   1 
ATOM   2828 C CD1  . TYR A 1 187 ? 22.01300 -17.37900 9.06000   1.000 47.32000  ? 187 TYR A CD1  1 
ATOM   2829 C CD2  . TYR A 1 187 ? 21.91400 -15.82800 10.89900  1.000 47.75000  ? 187 TYR A CD2  1 
ATOM   2830 C CE1  . TYR A 1 187 ? 20.82600 -17.96600 9.47600   1.000 48.67000  ? 187 TYR A CE1  1 
ATOM   2831 C CE2  . TYR A 1 187 ? 20.73400 -16.41500 11.34200  1.000 59.14000  ? 187 TYR A CE2  1 
ATOM   2832 C CZ   . TYR A 1 187 ? 20.18100 -17.48300 10.61700  1.000 57.45000  ? 187 TYR A CZ   1 
ATOM   2833 O OH   . TYR A 1 187 ? 18.98400 -18.04700 11.01200  1.000 80.38000  ? 187 TYR A OH   1 
ATOM   2834 H H    . TYR A 1 187 ? 24.80100 -16.55400 11.44500  1.000 59.73000  ? 187 TYR A H    1 
ATOM   2835 H HA   . TYR A 1 187 ? 24.82000 -17.55900 8.97900   1.000 66.28000  ? 187 TYR A HA   1 
ATOM   2836 H HB2  . TYR A 1 187 ? 24.10400 -14.96200 9.86100   1.000 66.44000  ? 187 TYR A HB2  1 
ATOM   2837 H HB3  . TYR A 1 187 ? 23.85700 -15.50000 8.38600   1.000 66.44000  ? 187 TYR A HB3  1 
ATOM   2838 H HD1  . TYR A 1 187 ? 22.44200 -17.70800 8.30300   1.000 56.66000  ? 187 TYR A HD1  1 
ATOM   2839 H HD2  . TYR A 1 187 ? 22.27100 -15.10700 11.36600  1.000 57.18000  ? 187 TYR A HD2  1 
ATOM   2840 H HE1  . TYR A 1 187 ? 20.46200 -18.67600 8.99800   1.000 58.28000  ? 187 TYR A HE1  1 
ATOM   2841 H HE2  . TYR A 1 187 ? 20.31600 -16.10500 12.11200  1.000 70.84000  ? 187 TYR A HE2  1 
ATOM   2842 H HH   . TYR A 1 187 ? 18.71300 -17.68100 11.71800  1.000 96.34000  ? 187 TYR A HH   1 
ATOM   2843 N N    . LEU A 1 188 ? 27.47200 -16.23900 9.72000   1.000 40.89000  ? 188 LEU A N    1 
ATOM   2844 C CA   . LEU A 1 188 ? 28.83100 -16.06300 9.26000   1.000 51.75000  ? 188 LEU A CA   1 
ATOM   2845 C C    . LEU A 1 188 ? 29.51000 -17.37800 8.87200   1.000 59.89000  ? 188 LEU A C    1 
ATOM   2846 O O    . LEU A 1 188 ? 30.68500 -17.36300 8.49800   1.000 59.11000  ? 188 LEU A O    1 
ATOM   2847 C CB   . LEU A 1 188 ? 29.59900 -15.36900 10.36800  1.000 45.91000  ? 188 LEU A CB   1 
ATOM   2848 C CG   . LEU A 1 188 ? 29.15400 -14.00300 10.83000  1.000 57.02000  ? 188 LEU A CG   1 
ATOM   2849 C CD1  . LEU A 1 188 ? 29.94200 -13.71900 12.12600  1.000 44.69000  ? 188 LEU A CD1  1 
ATOM   2850 C CD2  . LEU A 1 188 ? 29.40400 -12.95700 9.74700   1.000 54.57000  ? 188 LEU A CD2  1 
ATOM   2851 H H    . LEU A 1 188 ? 27.42900 -16.31700 10.57500  1.000 48.94000  ? 188 LEU A H    1 
ATOM   2852 H HA   . LEU A 1 188 ? 28.85100 -15.50800 8.46500   1.000 61.98000  ? 188 LEU A HA   1 
ATOM   2853 H HB2  . LEU A 1 188 ? 29.56600 -15.94600 11.14700  1.000 54.97000  ? 188 LEU A HB2  1 
ATOM   2854 H HB3  . LEU A 1 188 ? 30.51600 -15.27100 10.06600  1.000 54.97000  ? 188 LEU A HB3  1 
ATOM   2855 H HG   . LEU A 1 188 ? 28.20100 -13.96000 11.00500  1.000 68.31000  ? 188 LEU A HG   1 
ATOM   2856 H HD11 . LEU A 1 188 ? 29.71400 -12.83200 12.44500  1.000 53.50000  ? 188 LEU A HD11 1 
ATOM   2857 H HD12 . LEU A 1 188 ? 29.70400 -14.38200 12.79200  1.000 53.50000  ? 188 LEU A HD12 1 
ATOM   2858 H HD13 . LEU A 1 188 ? 30.89200 -13.76800 11.93500  1.000 53.50000  ? 188 LEU A HD13 1 
ATOM   2859 H HD21 . LEU A 1 188 ? 29.19400 -12.07900 10.10200  1.000 65.37000  ? 188 LEU A HD21 1 
ATOM   2860 H HD22 . LEU A 1 188 ? 30.33700 -12.99200 9.48300   1.000 65.37000  ? 188 LEU A HD22 1 
ATOM   2861 H HD23 . LEU A 1 188 ? 28.83700 -13.15000 8.98400   1.000 65.37000  ? 188 LEU A HD23 1 
ATOM   2862 N N    . GLU A 1 189 ? 28.79700 -18.49200 8.89300   1.000 54.26000  ? 189 GLU A N    1 
ATOM   2863 C CA   . GLU A 1 189 ? 29.40200 -19.81200 8.74500   1.000 52.56000  ? 189 GLU A CA   1 
ATOM   2864 C C    . GLU A 1 189 ? 29.17200 -20.33600 7.33200   1.000 45.73000  ? 189 GLU A C    1 
ATOM   2865 O O    . GLU A 1 189 ? 28.02400 -20.43900 6.88500   1.000 52.71000  ? 189 GLU A O    1 
ATOM   2866 C CB   . GLU A 1 189 ? 28.81100 -20.80800 9.75100   1.000 67.79000  ? 189 GLU A CB   1 
ATOM   2867 C CG   . GLU A 1 189 ? 29.08600 -20.47800 11.20700  1.000 59.01000  ? 189 GLU A CG   1 
ATOM   2868 C CD   . GLU A 1 189 ? 30.57000 -20.47700 11.48900  1.000 72.33000  ? 189 GLU A CD   1 
ATOM   2869 O OE1  . GLU A 1 189 ? 31.29600 -21.22700 10.79500  1.000 68.11000  ? 189 GLU A OE1  1 
ATOM   2870 O OE2  . GLU A 1 189 ? 31.01400 -19.72100 12.37600  1.000 87.31000  ? 189 GLU A OE2  1 
ATOM   2871 H H    . GLU A 1 189 ? 27.94300 -18.51300 8.99300   1.000 64.99000  ? 189 GLU A H    1 
ATOM   2872 H HA   . GLU A 1 189 ? 30.35600 -19.72500 8.89800   1.000 62.95000  ? 189 GLU A HA   1 
ATOM   2873 H HB2  . GLU A 1 189 ? 27.84800 -20.83000 9.63400   1.000 81.23000  ? 189 GLU A HB2  1 
ATOM   2874 H HB3  . GLU A 1 189 ? 29.18700 -21.68500 9.57400   1.000 81.23000  ? 189 GLU A HB3  1 
ATOM   2875 H HG2  . GLU A 1 189 ? 28.73300 -19.59800 11.41100  1.000 70.68000  ? 189 GLU A HG2  1 
ATOM   2876 H HG3  . GLU A 1 189 ? 28.66600 -21.14400 11.77400  1.000 70.68000  ? 189 GLU A HG3  1 
ATOM   2877 N N    . GLU A 1 190 ? 30.26400 -20.70100 6.66100   1.000 39.30000  ? 190 GLU A N    1 
ATOM   2878 C CA   . GLU A 1 190 ? 30.18700 -21.21000 5.29900   1.000 48.66000  ? 190 GLU A CA   1 
ATOM   2879 C C    . GLU A 1 190 ? 29.09600 -22.27200 5.16900   1.000 66.47000  ? 190 GLU A C    1 
ATOM   2880 O O    . GLU A 1 190 ? 28.27300 -22.22900 4.23500   1.000 55.54000  ? 190 GLU A O    1 
ATOM   2881 C CB   . GLU A 1 190 ? 31.56500 -21.75400 4.88300   1.000 50.86000  ? 190 GLU A CB   1 
ATOM   2882 C CG   . GLU A 1 190 ? 31.51500 -22.70400 3.68700   1.000 49.75000  ? 190 GLU A CG   1 
ATOM   2883 C CD   . GLU A 1 190 ? 32.88000 -23.07300 3.12600   1.000 60.87000  ? 190 GLU A CD   1 
ATOM   2884 O OE1  . GLU A 1 190 ? 33.87900 -23.02000 3.89300   1.000 66.97000  ? 190 GLU A OE1  1 
ATOM   2885 O OE2  . GLU A 1 190 ? 32.93700 -23.40000 1.90500   1.000 64.80000  ? 190 GLU A OE2  1 
ATOM   2886 H H    . GLU A 1 190 ? 31.06400 -20.66300 6.97500   1.000 47.04000  ? 190 GLU A H    1 
ATOM   2887 H HA   . GLU A 1 190 ? 29.95600 -20.48900 4.69300   1.000 58.27000  ? 190 GLU A HA   1 
ATOM   2888 H HB2  . GLU A 1 190 ? 32.13600 -21.00700 4.64400   1.000 60.91000  ? 190 GLU A HB2  1 
ATOM   2889 H HB3  . GLU A 1 190 ? 31.94800 -22.23800 5.63100   1.000 60.91000  ? 190 GLU A HB3  1 
ATOM   2890 H HG2  . GLU A 1 190 ? 31.07800 -23.52500 3.96100   1.000 59.58000  ? 190 GLU A HG2  1 
ATOM   2891 H HG3  . GLU A 1 190 ? 31.01000 -22.28000 2.97500   1.000 59.58000  ? 190 GLU A HG3  1 
ATOM   2892 N N    . LYS A 1 191 ? 29.06600 -23.23200 6.10700   1.000 66.96000  ? 191 LYS A N    1 
ATOM   2893 C CA   . LYS A 1 191 ? 28.11400 -24.33400 5.98700   1.000 66.74000  ? 191 LYS A CA   1 
ATOM   2894 C C    . LYS A 1 191 ? 26.68300 -23.86900 6.24700   1.000 69.56000  ? 191 LYS A C    1 
ATOM   2895 O O    . LYS A 1 191 ? 25.74400 -24.30800 5.56600   1.000 45.86000  ? 191 LYS A O    1 
ATOM   2896 C CB   . LYS A 1 191 ? 28.48500 -25.45100 6.95400   1.000 84.32000  ? 191 LYS A CB   1 
ATOM   2897 C CG   . LYS A 1 191 ? 27.43400 -26.52900 7.07900   1.000 94.37000  ? 191 LYS A CG   1 
ATOM   2898 C CD   . LYS A 1 191 ? 27.74400 -27.68200 6.12800   1.000 111.44000 ? 191 LYS A CD   1 
ATOM   2899 C CE   . LYS A 1 191 ? 28.95800 -28.50400 6.61700   1.000 121.95000 ? 191 LYS A CE   1 
ATOM   2900 N NZ   . LYS A 1 191 ? 28.80500 -29.98100 6.38000   1.000 87.88000  ? 191 LYS A NZ   1 
ATOM   2901 H H    . LYS A 1 191 ? 29.57300 -23.26300 6.80100   1.000 80.23000  ? 191 LYS A H    1 
ATOM   2902 H HA   . LYS A 1 191 ? 28.16000 -24.68200 5.08300   1.000 79.97000  ? 191 LYS A HA   1 
ATOM   2903 H HB2  . LYS A 1 191 ? 29.30300 -25.87000 6.64600   1.000 101.06000 ? 191 LYS A HB2  1 
ATOM   2904 H HB3  . LYS A 1 191 ? 28.62100 -25.06700 7.83500   1.000 101.06000 ? 191 LYS A HB3  1 
ATOM   2905 H HG2  . LYS A 1 191 ? 27.42200 -26.87000 7.98700   1.000 113.12000 ? 191 LYS A HG2  1 
ATOM   2906 H HG3  . LYS A 1 191 ? 26.56400 -26.16400 6.85000   1.000 113.12000 ? 191 LYS A HG3  1 
ATOM   2907 H HD2  . LYS A 1 191 ? 26.97700 -28.27200 6.07700   1.000 133.61000 ? 191 LYS A HD2  1 
ATOM   2908 H HD3  . LYS A 1 191 ? 27.95000 -27.32800 5.24900   1.000 133.61000 ? 191 LYS A HD3  1 
ATOM   2909 H HE2  . LYS A 1 191 ? 29.75000 -28.20700 6.14300   1.000 146.22000 ? 191 LYS A HE2  1 
ATOM   2910 H HE3  . LYS A 1 191 ? 29.06900 -28.36500 7.57000   1.000 146.22000 ? 191 LYS A HE3  1 
ATOM   2911 H HZ1  . LYS A 1 191 ? 29.52200 -30.41300 6.68400   1.000 105.33000 ? 191 LYS A HZ1  1 
ATOM   2912 H HZ2  . LYS A 1 191 ? 28.08400 -30.28400 6.80400   1.000 105.33000 ? 191 LYS A HZ2  1 
ATOM   2913 H HZ3  . LYS A 1 191 ? 28.71800 -30.14200 5.51000   1.000 105.33000 ? 191 LYS A HZ3  1 
ATOM   2914 N N    . ARG A 1 192 ? 26.48700 -23.03300 7.26600   1.000 60.49000  ? 192 ARG A N    1 
ATOM   2915 C CA   . ARG A 1 192 ? 25.14700 -22.53000 7.52100   1.000 59.91000  ? 192 ARG A CA   1 
ATOM   2916 C C    . ARG A 1 192 ? 24.64400 -21.72000 6.34000   1.000 62.08000  ? 192 ARG A C    1 
ATOM   2917 O O    . ARG A 1 192 ? 23.48700 -21.84500 5.93700   1.000 67.86000  ? 192 ARG A O    1 
ATOM   2918 C CB   . ARG A 1 192 ? 25.14400 -21.70500 8.78900   1.000 42.38000  ? 192 ARG A CB   1 
ATOM   2919 C CG   . ARG A 1 192 ? 23.80100 -21.21800 9.16700   1.000 58.29000  ? 192 ARG A CG   1 
ATOM   2920 C CD   . ARG A 1 192 ? 22.75100 -22.33800 9.38000   1.000 55.49000  ? 192 ARG A CD   1 
ATOM   2921 N NE   . ARG A 1 192 ? 21.66100 -21.82800 10.22300  1.000 51.55000  ? 192 ARG A NE   1 
ATOM   2922 C CZ   . ARG A 1 192 ? 20.39100 -21.78000 9.84900   1.000 60.17000  ? 192 ARG A CZ   1 
ATOM   2923 N NH1  . ARG A 1 192 ? 19.97000 -22.43200 8.77300   1.000 46.07000  ? 192 ARG A NH1  1 
ATOM   2924 N NH2  . ARG A 1 192 ? 19.54200 -21.00400 10.52900  1.000 60.78000  ? 192 ARG A NH2  1 
ATOM   2925 H H    . ARG A 1 192 ? 27.09500 -22.75300 7.80600   1.000 72.46000  ? 192 ARG A H    1 
ATOM   2926 H HA   . ARG A 1 192 ? 24.54000 -23.27500 7.65200   1.000 71.77000  ? 192 ARG A HA   1 
ATOM   2927 H HB2  . ARG A 1 192 ? 25.47900 -22.25000 9.51800   1.000 50.74000  ? 192 ARG A HB2  1 
ATOM   2928 H HB3  . ARG A 1 192 ? 25.71600 -20.93200 8.66200   1.000 50.74000  ? 192 ARG A HB3  1 
ATOM   2929 H HG2  . ARG A 1 192 ? 23.87300 -20.72300 9.99800   1.000 69.82000  ? 192 ARG A HG2  1 
ATOM   2930 H HG3  . ARG A 1 192 ? 23.47200 -20.63800 8.46300   1.000 69.82000  ? 192 ARG A HG3  1 
ATOM   2931 H HD2  . ARG A 1 192 ? 22.38500 -22.61300 8.52400   1.000 66.47000  ? 192 ARG A HD2  1 
ATOM   2932 H HD3  . ARG A 1 192 ? 23.16300 -23.09600 9.82300   1.000 66.47000  ? 192 ARG A HD3  1 
ATOM   2933 H HE   . ARG A 1 192 ? 21.86000 -21.54300 11.01000  1.000 61.73000  ? 192 ARG A HE   1 
ATOM   2934 H HH11 . ARG A 1 192 ? 20.52500 -22.89500 8.30700   1.000 55.16000  ? 192 ARG A HH11 1 
ATOM   2935 H HH12 . ARG A 1 192 ? 19.14300 -22.39200 8.54200   1.000 55.16000  ? 192 ARG A HH12 1 
ATOM   2936 H HH21 . ARG A 1 192 ? 19.82200 -20.54400 11.19900  1.000 72.81000  ? 192 ARG A HH21 1 
ATOM   2937 H HH22 . ARG A 1 192 ? 18.71500 -20.96400 10.29600  1.000 72.81000  ? 192 ARG A HH22 1 
ATOM   2938 N N    . ILE A 1 193 ? 25.49600 -20.89400 5.75300   1.000 64.85000  ? 193 ILE A N    1 
ATOM   2939 C CA   . ILE A 1 193 ? 25.04100 -20.09500 4.62600   1.000 58.22000  ? 193 ILE A CA   1 
ATOM   2940 C C    . ILE A 1 193 ? 24.75800 -20.98300 3.41800   1.000 49.54000  ? 193 ILE A C    1 
ATOM   2941 O O    . ILE A 1 193 ? 23.83200 -20.71200 2.63000   1.000 51.64000  ? 193 ILE A O    1 
ATOM   2942 C CB   . ILE A 1 193 ? 26.08900 -19.02300 4.29000   1.000 61.95000  ? 193 ILE A CB   1 
ATOM   2943 C CG1  . ILE A 1 193 ? 26.25400 -18.00500 5.40100   1.000 53.31000  ? 193 ILE A CG1  1 
ATOM   2944 C CG2  . ILE A 1 193 ? 25.75900 -18.31600 2.95800   1.000 47.07000  ? 193 ILE A CG2  1 
ATOM   2945 C CD1  . ILE A 1 193 ? 27.57000 -17.18700 5.22500   1.000 49.79000  ? 193 ILE A CD1  1 
ATOM   2946 H H    . ILE A 1 193 ? 26.31800 -20.78000 5.98100   1.000 77.70000  ? 193 ILE A H    1 
ATOM   2947 H HA   . ILE A 1 193 ? 24.21300 -19.65500 4.87500   1.000 69.74000  ? 193 ILE A HA   1 
ATOM   2948 H HB   . ILE A 1 193 ? 26.93400 -19.49000 4.19700   1.000 74.21000  ? 193 ILE A HB   1 
ATOM   2949 H HG12 . ILE A 1 193 ? 25.50500 -17.38800 5.38600   1.000 63.85000  ? 193 ILE A HG12 1 
ATOM   2950 H HG13 . ILE A 1 193 ? 26.28900 -18.46300 6.25500   1.000 63.85000  ? 193 ILE A HG13 1 
ATOM   2951 H HG21 . ILE A 1 193 ? 26.27100 -17.49400 2.90100   1.000 56.36000  ? 193 ILE A HG21 1 
ATOM   2952 H HG22 . ILE A 1 193 ? 25.99400 -18.90300 2.22200   1.000 56.36000  ? 193 ILE A HG22 1 
ATOM   2953 H HG23 . ILE A 1 193 ? 24.81000 -18.11700 2.93200   1.000 56.36000  ? 193 ILE A HG23 1 
ATOM   2954 H HD11 . ILE A 1 193 ? 27.79900 -16.77200 6.07100   1.000 59.63000  ? 193 ILE A HD11 1 
ATOM   2955 H HD12 . ILE A 1 193 ? 28.28000 -17.78700 4.94800   1.000 59.63000  ? 193 ILE A HD12 1 
ATOM   2956 H HD13 . ILE A 1 193 ? 27.43100 -16.50500 4.54900   1.000 59.63000  ? 193 ILE A HD13 1 
ATOM   2957 N N    . LYS A 1 194 ? 25.59500 -22.01300 3.20100   1.000 57.06000  ? 194 LYS A N    1 
ATOM   2958 C CA   . LYS A 1 194 ? 25.34100 -22.95900 2.11100   1.000 60.79000  ? 194 LYS A CA   1 
ATOM   2959 C C    . LYS A 1 194 ? 23.96400 -23.63000 2.26300   1.000 58.31000  ? 194 LYS A C    1 
ATOM   2960 O O    . LYS A 1 194 ? 23.20900 -23.74500 1.28900   1.000 56.54000  ? 194 LYS A O    1 
ATOM   2961 C CB   . LYS A 1 194 ? 26.47800 -23.97900 2.03600   1.000 59.09000  ? 194 LYS A CB   1 
ATOM   2962 C CG   . LYS A 1 194 ? 27.32900 -23.87100 0.76100   1.000 70.47000  ? 194 LYS A CG   1 
ATOM   2963 C CD   . LYS A 1 194 ? 28.37600 -24.98900 0.69700   1.000 79.99000  ? 194 LYS A CD   1 
ATOM   2964 C CE   . LYS A 1 194 ? 29.72100 -24.51100 1.19700   1.000 91.52000  ? 194 LYS A CE   1 
ATOM   2965 N NZ   . LYS A 1 194 ? 30.88100 -25.15300 0.47800   1.000 93.51000  ? 194 LYS A NZ   1 
ATOM   2966 H H    . LYS A 1 194 ? 26.30100 -22.17900 3.66300   1.000 68.35000  ? 194 LYS A H    1 
ATOM   2967 H HA   . LYS A 1 194 ? 25.32800 -22.48500 1.26400   1.000 72.83000  ? 194 LYS A HA   1 
ATOM   2968 H HB2  . LYS A 1 194 ? 27.06500 -23.84600 2.79600   1.000 70.78000  ? 194 LYS A HB2  1 
ATOM   2969 H HB3  . LYS A 1 194 ? 26.09700 -24.87100 2.06300   1.000 70.78000  ? 194 LYS A HB3  1 
ATOM   2970 H HG2  . LYS A 1 194 ? 26.75500 -23.94400 -0.01700  1.000 84.44000  ? 194 LYS A HG2  1 
ATOM   2971 H HG3  . LYS A 1 194 ? 27.79100 -23.01800 0.75400   1.000 84.44000  ? 194 LYS A HG3  1 
ATOM   2972 H HD2  . LYS A 1 194 ? 28.09000 -25.73100 1.25100   1.000 95.86000  ? 194 LYS A HD2  1 
ATOM   2973 H HD3  . LYS A 1 194 ? 28.47800 -25.28100 -0.22300  1.000 95.86000  ? 194 LYS A HD3  1 
ATOM   2974 H HE2  . LYS A 1 194 ? 29.78300 -23.55200 1.06700   1.000 109.70000 ? 194 LYS A HE2  1 
ATOM   2975 H HE3  . LYS A 1 194 ? 29.80000 -24.72400 2.14000   1.000 109.70000 ? 194 LYS A HE3  1 
ATOM   2976 H HZ1  . LYS A 1 194 ? 31.63400 -25.01600 0.93200   1.000 112.08000 ? 194 LYS A HZ1  1 
ATOM   2977 H HZ2  . LYS A 1 194 ? 30.74500 -26.02900 0.40100   1.000 112.08000 ? 194 LYS A HZ2  1 
ATOM   2978 H HZ3  . LYS A 1 194 ? 30.96600 -24.80100 -0.33600  1.000 112.08000 ? 194 LYS A HZ3  1 
ATOM   2979 N N    . GLU A 1 195 ? 23.58300 -23.99600 3.48600   1.000 54.21000  ? 195 GLU A N    1 
ATOM   2980 C CA   . GLU A 1 195 ? 22.26300 -24.56700 3.69700   1.000 64.93000  ? 195 GLU A CA   1 
ATOM   2981 C C    . GLU A 1 195 ? 21.17500 -23.63300 3.18700   1.000 62.72000  ? 195 GLU A C    1 
ATOM   2982 O O    . GLU A 1 195 ? 20.38100 -23.99600 2.30500   1.000 52.73000  ? 195 GLU A O    1 
ATOM   2983 C CB   . GLU A 1 195 ? 22.05100 -24.86100 5.18200   1.000 64.46000  ? 195 GLU A CB   1 
ATOM   2984 C CG   . GLU A 1 195 ? 22.77800 -26.09700 5.69900   1.000 80.61000  ? 195 GLU A CG   1 
ATOM   2985 C CD   . GLU A 1 195 ? 22.80200 -26.13600 7.19800   1.000 99.58000  ? 195 GLU A CD   1 
ATOM   2986 O OE1  . GLU A 1 195 ? 22.11100 -25.28800 7.82300   1.000 91.13000  ? 195 GLU A OE1  1 
ATOM   2987 O OE2  . GLU A 1 195 ? 23.53800 -26.99200 7.73700   1.000 92.70000  ? 195 GLU A OE2  1 
ATOM   2988 H H    . GLU A 1 195 ? 24.06300 -23.92400 4.19500   1.000 64.93000  ? 195 GLU A H    1 
ATOM   2989 H HA   . GLU A 1 195 ? 22.20600 -25.40200 3.20600   1.000 77.79000  ? 195 GLU A HA   1 
ATOM   2990 H HB2  . GLU A 1 195 ? 22.36700 -24.10100 5.69400   1.000 77.22000  ? 195 GLU A HB2  1 
ATOM   2991 H HB3  . GLU A 1 195 ? 21.10300 -24.99500 5.33700   1.000 77.22000  ? 195 GLU A HB3  1 
ATOM   2992 H HG2  . GLU A 1 195 ? 22.32400 -26.89300 5.38000   1.000 96.61000  ? 195 GLU A HG2  1 
ATOM   2993 H HG3  . GLU A 1 195 ? 23.69400 -26.08700 5.38000   1.000 96.61000  ? 195 GLU A HG3  1 
ATOM   2994 N N    . VAL A 1 196 ? 21.12600 -22.42100 3.76100   1.000 52.28000  ? 196 VAL A N    1 
ATOM   2995 C CA   . VAL A 1 196 ? 20.03300 -21.48000 3.51300   1.000 46.03000  ? 196 VAL A CA   1 
ATOM   2996 C C    . VAL A 1 196 ? 19.90700 -21.16700 2.01800   1.000 51.72000  ? 196 VAL A C    1 
ATOM   2997 O O    . VAL A 1 196 ? 18.80500 -21.19200 1.46100   1.000 50.73000  ? 196 VAL A O    1 
ATOM   2998 C CB   . VAL A 1 196 ? 20.24700 -20.21600 4.37400   1.000 57.01000  ? 196 VAL A CB   1 
ATOM   2999 C CG1  . VAL A 1 196 ? 19.24500 -19.17100 4.05000   1.000 51.19000  ? 196 VAL A CG1  1 
ATOM   3000 C CG2  . VAL A 1 196 ? 20.27100 -20.56000 5.88000   1.000 40.91000  ? 196 VAL A CG2  1 
ATOM   3001 H H    . VAL A 1 196 ? 21.72100 -22.11900 4.30400   1.000 62.62000  ? 196 VAL A H    1 
ATOM   3002 H HA   . VAL A 1 196 ? 19.19300 -21.88500 3.77800   1.000 55.12000  ? 196 VAL A HA   1 
ATOM   3003 H HB   . VAL A 1 196 ? 21.11700 -19.84400 4.16100   1.000 68.28000  ? 196 VAL A HB   1 
ATOM   3004 H HG11 . VAL A 1 196 ? 19.19900 -18.53900 4.78400   1.000 61.30000  ? 196 VAL A HG11 1 
ATOM   3005 H HG12 . VAL A 1 196 ? 19.51400 -18.71600 3.23700   1.000 61.30000  ? 196 VAL A HG12 1 
ATOM   3006 H HG13 . VAL A 1 196 ? 18.38000 -19.59200 3.92200   1.000 61.30000  ? 196 VAL A HG13 1 
ATOM   3007 H HG21 . VAL A 1 196 ? 20.31200 -19.73600 6.39100   1.000 48.97000  ? 196 VAL A HG21 1 
ATOM   3008 H HG22 . VAL A 1 196 ? 19.46400 -21.04900 6.10500   1.000 48.97000  ? 196 VAL A HG22 1 
ATOM   3009 H HG23 . VAL A 1 196 ? 21.05100 -21.10500 6.06800   1.000 48.97000  ? 196 VAL A HG23 1 
ATOM   3010 N N    . VAL A 1 197 ? 21.03200 -20.95700 1.32600   1.000 48.78000  ? 197 VAL A N    1 
ATOM   3011 C CA   . VAL A 1 197 ? 20.96500 -20.64600 -0.10900  1.000 53.54000  ? 197 VAL A CA   1 
ATOM   3012 C C    . VAL A 1 197 ? 20.37000 -21.81200 -0.90600  1.000 62.48000  ? 197 VAL A C    1 
ATOM   3013 O O    . VAL A 1 197 ? 19.47100 -21.62000 -1.73900  1.000 68.13000  ? 197 VAL A O    1 
ATOM   3014 C CB   . VAL A 1 197 ? 22.35400 -20.27100 -0.66100  1.000 52.70000  ? 197 VAL A CB   1 
ATOM   3015 C CG1  . VAL A 1 197 ? 22.31600 -20.31900 -2.17500  1.000 40.68000  ? 197 VAL A CG1  1 
ATOM   3016 C CG2  . VAL A 1 197 ? 22.75700 -18.90200 -0.21000  1.000 57.34000  ? 197 VAL A CG2  1 
ATOM   3017 H H    . VAL A 1 197 ? 21.82700 -20.98800 1.65300   1.000 58.42000  ? 197 VAL A H    1 
ATOM   3018 H HA   . VAL A 1 197 ? 20.37600 -19.88100 -0.20400  1.000 64.13000  ? 197 VAL A HA   1 
ATOM   3019 H HB   . VAL A 1 197 ? 23.01000 -20.90300 -0.32800  1.000 63.11000  ? 197 VAL A HB   1 
ATOM   3020 H HG11 . VAL A 1 197 ? 23.07300 -19.82400 -2.52600  1.000 48.69000  ? 197 VAL A HG11 1 
ATOM   3021 H HG12 . VAL A 1 197 ? 22.36400 -21.24400 -2.46300  1.000 48.69000  ? 197 VAL A HG12 1 
ATOM   3022 H HG13 . VAL A 1 197 ? 21.48800 -19.91900 -2.48300  1.000 48.69000  ? 197 VAL A HG13 1 
ATOM   3023 H HG21 . VAL A 1 197 ? 23.65900 -18.72000 -0.52000  1.000 68.69000  ? 197 VAL A HG21 1 
ATOM   3024 H HG22 . VAL A 1 197 ? 22.14200 -18.25200 -0.58400  1.000 68.69000  ? 197 VAL A HG22 1 
ATOM   3025 H HG23 . VAL A 1 197 ? 22.72700 -18.86700 0.75900   1.000 68.69000  ? 197 VAL A HG23 1 
ATOM   3026 N N    . LYS A 1 198 ? 20.92700 -23.02300 -0.73300  1.000 69.96000  ? 198 LYS A N    1 
ATOM   3027 C CA   . LYS A 1 198 ? 20.47600 -24.18500 -1.50700  1.000 74.71000  ? 198 LYS A CA   1 
ATOM   3028 C C    . LYS A 1 198 ? 18.98300 -24.48800 -1.27700  1.000 71.46000  ? 198 LYS A C    1 
ATOM   3029 O O    . LYS A 1 198 ? 18.25300 -24.79900 -2.24500  1.000 53.04000  ? 198 LYS A O    1 
ATOM   3030 C CB   . LYS A 1 198 ? 21.39300 -25.35800 -1.15900  1.000 64.45000  ? 198 LYS A CB   1 
ATOM   3031 C CG   . LYS A 1 198 ? 22.87500 -25.14000 -1.57400  1.000 70.32000  ? 198 LYS A CG   1 
ATOM   3032 C CD   . LYS A 1 198 ? 23.84200 -26.28200 -1.15500  1.000 90.83000  ? 198 LYS A CD   1 
ATOM   3033 C CE   . LYS A 1 198 ? 23.47100 -27.64900 -1.79500  1.000 108.94000 ? 198 LYS A CE   1 
ATOM   3034 N NZ   . LYS A 1 198 ? 24.19200 -28.81600 -1.19100  1.000 110.61000 ? 198 LYS A NZ   1 
ATOM   3035 H H    . LYS A 1 198 ? 21.56200 -23.19400 -0.17900  1.000 83.83000  ? 198 LYS A H    1 
ATOM   3036 H HA   . LYS A 1 198 ? 20.55000 -24.02300 -2.46000  1.000 89.53000  ? 198 LYS A HA   1 
ATOM   3037 H HB2  . LYS A 1 198 ? 21.37200 -25.49700 -0.19900  1.000 77.22000  ? 198 LYS A HB2  1 
ATOM   3038 H HB3  . LYS A 1 198 ? 21.07200 -26.15200 -1.61500  1.000 77.22000  ? 198 LYS A HB3  1 
ATOM   3039 H HG2  . LYS A 1 198 ? 22.91700 -25.06300 -2.54000  1.000 84.26000  ? 198 LYS A HG2  1 
ATOM   3040 H HG3  . LYS A 1 198 ? 23.19400 -24.32200 -1.16200  1.000 84.26000  ? 198 LYS A HG3  1 
ATOM   3041 H HD2  . LYS A 1 198 ? 24.74200 -26.05400 -1.43700  1.000 108.87000 ? 198 LYS A HD2  1 
ATOM   3042 H HD3  . LYS A 1 198 ? 23.81300 -26.38400 -0.19100  1.000 108.87000 ? 198 LYS A HD3  1 
ATOM   3043 H HE2  . LYS A 1 198 ? 22.51900 -27.79900 -1.68000  1.000 130.61000 ? 198 LYS A HE2  1 
ATOM   3044 H HE3  . LYS A 1 198 ? 23.69100 -27.62200 -2.73900  1.000 130.61000 ? 198 LYS A HE3  1 
ATOM   3045 H HZ1  . LYS A 1 198 ? 23.93800 -29.57000 -1.59100  1.000 132.61000 ? 198 LYS A HZ1  1 
ATOM   3046 H HZ2  . LYS A 1 198 ? 25.07000 -28.71600 -1.29300  1.000 132.61000 ? 198 LYS A HZ2  1 
ATOM   3047 H HZ3  . LYS A 1 198 ? 24.00600 -28.87200 -0.32300  1.000 132.61000 ? 198 LYS A HZ3  1 
ATOM   3048 N N    . LYS A 1 199 ? 18.50400 -24.26200 -0.03800  1.000 48.07000  ? 199 LYS A N    1 
ATOM   3049 C CA   . LYS A 1 199 ? 17.09800 -24.43600 0.33600   1.000 63.35000  ? 199 LYS A CA   1 
ATOM   3050 C C    . LYS A 1 199 ? 16.14300 -23.50000 -0.41300  1.000 71.45000  ? 199 LYS A C    1 
ATOM   3051 O O    . LYS A 1 199 ? 15.08800 -23.93100 -0.89200  1.000 73.07000  ? 199 LYS A O    1 
ATOM   3052 C CB   . LYS A 1 199 ? 16.95000 -24.21300 1.85300   1.000 57.10000  ? 199 LYS A CB   1 
ATOM   3053 C CG   . LYS A 1 199 ? 15.54500 -24.37500 2.40200   1.000 73.81000  ? 199 LYS A CG   1 
ATOM   3054 C CD   . LYS A 1 199 ? 15.56500 -25.30100 3.64300   1.000 97.01000  ? 199 LYS A CD   1 
ATOM   3055 C CE   . LYS A 1 199 ? 14.46400 -24.98900 4.67400   1.000 112.56000 ? 199 LYS A CE   1 
ATOM   3056 N NZ   . LYS A 1 199 ? 14.78400 -25.53200 6.04800   1.000 117.61000 ? 199 LYS A NZ   1 
ATOM   3057 H H    . LYS A 1 199 ? 18.99100 -23.99900 0.62000   1.000 57.57000  ? 199 LYS A H    1 
ATOM   3058 H HA   . LYS A 1 199 ? 16.84600 -25.34300 0.10000   1.000 75.90000  ? 199 LYS A HA   1 
ATOM   3059 H HB2  . LYS A 1 199 ? 17.51500 -24.85400 2.31200   1.000 68.40000  ? 199 LYS A HB2  1 
ATOM   3060 H HB3  . LYS A 1 199 ? 17.23800 -23.31000 2.05800   1.000 68.40000  ? 199 LYS A HB3  1 
ATOM   3061 H HG2  . LYS A 1 199 ? 15.19500 -23.50900 2.66600   1.000 88.45000  ? 199 LYS A HG2  1 
ATOM   3062 H HG3  . LYS A 1 199 ? 14.97300 -24.77200 1.72700   1.000 88.45000  ? 199 LYS A HG3  1 
ATOM   3063 H HD2  . LYS A 1 199 ? 15.44200 -26.21800 3.35000   1.000 116.29000 ? 199 LYS A HD2  1 
ATOM   3064 H HD3  . LYS A 1 199 ? 16.42100 -25.20700 4.08900   1.000 116.29000 ? 199 LYS A HD3  1 
ATOM   3065 H HE2  . LYS A 1 199 ? 14.36200 -24.02700 4.74800   1.000 134.95000 ? 199 LYS A HE2  1 
ATOM   3066 H HE3  . LYS A 1 199 ? 13.63100 -25.38900 4.38000   1.000 134.95000 ? 199 LYS A HE3  1 
ATOM   3067 H HZ1  . LYS A 1 199 ? 14.13000 -25.32900 6.61600   1.000 141.01000 ? 199 LYS A HZ1  1 
ATOM   3068 H HZ2  . LYS A 1 199 ? 14.87200 -26.41700 6.01300   1.000 141.01000 ? 199 LYS A HZ2  1 
ATOM   3069 H HZ3  . LYS A 1 199 ? 15.54500 -25.17800 6.34500   1.000 141.01000 ? 199 LYS A HZ3  1 
ATOM   3070 N N    . HIS A 1 200 ? 16.44700 -22.20600 -0.46400  1.000 65.25000  ? 200 HIS A N    1 
ATOM   3071 C CA   . HIS A 1 200 ? 15.41000 -21.22500 -0.76200  1.000 58.56000  ? 200 HIS A CA   1 
ATOM   3072 C C    . HIS A 1 200 ? 15.70100 -20.39700 -1.99600  1.000 53.42000  ? 200 HIS A C    1 
ATOM   3073 O O    . HIS A 1 200 ? 14.91300 -19.49100 -2.31100  1.000 68.28000  ? 200 HIS A O    1 
ATOM   3074 C CB   . HIS A 1 200 ? 15.21100 -20.24700 0.41700   1.000 71.04000  ? 200 HIS A CB   1 
ATOM   3075 C CG   . HIS A 1 200 ? 14.55200 -20.82700 1.64400   1.000 68.80000  ? 200 HIS A CG   1 
ATOM   3076 N ND1  . HIS A 1 200 ? 13.26800 -21.32900 1.63800   1.000 75.43000  ? 200 HIS A ND1  1 
ATOM   3077 C CD2  . HIS A 1 200 ? 14.98600 -20.93300 2.92700   1.000 82.47000  ? 200 HIS A CD2  1 
ATOM   3078 C CE1  . HIS A 1 200 ? 12.94500 -21.73100 2.85800   1.000 89.52000  ? 200 HIS A CE1  1 
ATOM   3079 N NE2  . HIS A 1 200 ? 13.96700 -21.49900 3.66100   1.000 90.27000  ? 200 HIS A NE2  1 
ATOM   3080 H H    . HIS A 1 200 ? 17.23100 -21.87800 -0.33100  1.000 78.18000  ? 200 HIS A H    1 
ATOM   3081 H HA   . HIS A 1 200 ? 14.58600 -21.71800 -0.89800  1.000 70.14000  ? 200 HIS A HA   1 
ATOM   3082 H HB2  . HIS A 1 200 ? 16.08200 -19.91500 0.68800   1.000 85.12000  ? 200 HIS A HB2  1 
ATOM   3083 H HB3  . HIS A 1 200 ? 14.65600 -19.51200 0.11300   1.000 85.12000  ? 200 HIS A HB3  1 
ATOM   3084 H HD2  . HIS A 1 200 ? 15.81800 -20.67100 3.25100   1.000 98.84000  ? 200 HIS A HD2  1 
ATOM   3085 H HE1  . HIS A 1 200 ? 12.13400 -22.11200 3.10700   1.000 107.31000 ? 200 HIS A HE1  1 
ATOM   3086 H HE2  . HIS A 1 200 ? 13.99200 -21.67200 4.50300   1.000 108.20000 ? 200 HIS A HE2  1 
ATOM   3087 N N    . SER A 1 201 ? 16.83100 -20.62200 -2.66900  1.000 53.88000  ? 201 SER A N    1 
ATOM   3088 C CA   . SER A 1 201 ? 17.21200 -19.84100 -3.84800  1.000 58.30000  ? 201 SER A CA   1 
ATOM   3089 C C    . SER A 1 201 ? 17.84100 -20.75400 -4.90600  1.000 74.86000  ? 201 SER A C    1 
ATOM   3090 O O    . SER A 1 201 ? 18.92000 -20.49800 -5.45400  1.000 60.30000  ? 201 SER A O    1 
ATOM   3091 C CB   . SER A 1 201 ? 18.16100 -18.70500 -3.47200  1.000 76.51000  ? 201 SER A CB   1 
ATOM   3092 O OG   . SER A 1 201 ? 17.70900 -17.99100 -2.34700  1.000 57.68000  ? 201 SER A OG   1 
ATOM   3093 H H    . SER A 1 201 ? 17.40100 -21.23100 -2.45900  1.000 64.53000  ? 201 SER A H    1 
ATOM   3094 H HA   . SER A 1 201 ? 16.40800 -19.45500 -4.22700  1.000 69.84000  ? 201 SER A HA   1 
ATOM   3095 H HB2  . SER A 1 201 ? 19.03200 -19.08100 -3.27200  1.000 91.68000  ? 201 SER A HB2  1 
ATOM   3096 H HB3  . SER A 1 201 ? 18.22700 -18.09400 -4.22300  1.000 91.68000  ? 201 SER A HB3  1 
ATOM   3097 H HG   . SER A 1 201 ? 18.23000 -17.35300 -2.18400  1.000 69.09000  ? 201 SER A HG   1 
ATOM   3098 N N    . GLU A 1 202 ? 17.13700 -21.85000 -5.19400  1.000 88.44000  ? 202 GLU A N    1 
ATOM   3099 C CA   . GLU A 1 202 ? 17.51500 -22.73200 -6.29000  1.000 82.90000  ? 202 GLU A CA   1 
ATOM   3100 C C    . GLU A 1 202 ? 17.32600 -22.05500 -7.65000  1.000 82.00000  ? 202 GLU A C    1 
ATOM   3101 O O    . GLU A 1 202 ? 18.15100 -22.24600 -8.54600  1.000 81.69000  ? 202 GLU A O    1 
ATOM   3102 C CB   . GLU A 1 202 ? 16.69000 -24.01300 -6.17000  1.000 85.63000  ? 202 GLU A CB   1 
ATOM   3103 C CG   . GLU A 1 202 ? 16.62900 -24.93200 -7.38100  1.000 97.04000  ? 202 GLU A CG   1 
ATOM   3104 C CD   . GLU A 1 202 ? 15.72700 -26.16800 -7.12700  1.000 105.85000 ? 202 GLU A CD   1 
ATOM   3105 O OE1  . GLU A 1 202 ? 15.39600 -26.44400 -5.93900  1.000 106.26000 ? 202 GLU A OE1  1 
ATOM   3106 O OE2  . GLU A 1 202 ? 15.36900 -26.87400 -8.10600  1.000 85.57000  ? 202 GLU A OE2  1 
ATOM   3107 H H    . GLU A 1 202 ? 16.43500 -22.10500 -4.76700  1.000 106.00000 ? 202 GLU A H    1 
ATOM   3108 H HA   . GLU A 1 202 ? 18.45600 -22.96200 -6.23200  1.000 99.36000  ? 202 GLU A HA   1 
ATOM   3109 H HB2  . GLU A 1 202 ? 17.05900 -24.53600 -5.44100  1.000 102.63000 ? 202 GLU A HB2  1 
ATOM   3110 H HB3  . GLU A 1 202 ? 15.77600 -23.75900 -5.96700  1.000 102.63000 ? 202 GLU A HB3  1 
ATOM   3111 H HG2  . GLU A 1 202 ? 16.26600 -24.44100 -8.13600  1.000 116.33000 ? 202 GLU A HG2  1 
ATOM   3112 H HG3  . GLU A 1 202 ? 17.52300 -25.24600 -7.58900  1.000 116.33000 ? 202 GLU A HG3  1 
ATOM   3113 N N    . PHE A 1 203 ? 16.29800 -21.21200 -7.81200  1.000 72.68000  ? 203 PHE A N    1 
ATOM   3114 C CA   . PHE A 1 203 ? 15.90600 -20.73200 -9.14200  1.000 48.06000  ? 203 PHE A CA   1 
ATOM   3115 C C    . PHE A 1 203 ? 16.32700 -19.29200 -9.38000  1.000 51.40000  ? 203 PHE A C    1 
ATOM   3116 O O    . PHE A 1 203 ? 15.53900 -18.40500 -9.75000  1.000 54.04000  ? 203 PHE A O    1 
ATOM   3117 C CB   . PHE A 1 203 ? 14.41200 -20.89200 -9.33700  1.000 49.57000  ? 203 PHE A CB   1 
ATOM   3118 C CG   . PHE A 1 203 ? 14.04100 -22.27100 -9.67200  1.000 62.09000  ? 203 PHE A CG   1 
ATOM   3119 C CD1  . PHE A 1 203 ? 14.43800 -22.80700 -10.88100 1.000 80.57000  ? 203 PHE A CD1  1 
ATOM   3120 C CD2  . PHE A 1 203 ? 13.38000 -23.07500 -8.76900  1.000 77.38000  ? 203 PHE A CD2  1 
ATOM   3121 C CE1  . PHE A 1 203 ? 14.14800 -24.10200 -11.19700 1.000 77.59000  ? 203 PHE A CE1  1 
ATOM   3122 C CE2  . PHE A 1 203 ? 13.06900 -24.37700 -9.09500  1.000 76.04000  ? 203 PHE A CE2  1 
ATOM   3123 C CZ   . PHE A 1 203 ? 13.46600 -24.89100 -10.30500 1.000 78.04000  ? 203 PHE A CZ   1 
ATOM   3124 H H    . PHE A 1 203 ? 15.81500 -20.90600 -7.16900  1.000 87.10000  ? 203 PHE A H    1 
ATOM   3125 H HA   . PHE A 1 203 ? 16.37100 -21.27900 -9.79400  1.000 57.55000  ? 203 PHE A HA   1 
ATOM   3126 H HB2  . PHE A 1 203 ? 13.95600 -20.64700 -8.51700  1.000 59.37000  ? 203 PHE A HB2  1 
ATOM   3127 H HB3  . PHE A 1 203 ? 14.12300 -20.31700 -10.06300 1.000 59.37000  ? 203 PHE A HB3  1 
ATOM   3128 H HD1  . PHE A 1 203 ? 14.90600 -22.27900 -11.48600 1.000 96.56000  ? 203 PHE A HD1  1 
ATOM   3129 H HD2  . PHE A 1 203 ? 13.14200 -22.73700 -7.93500  1.000 92.73000  ? 203 PHE A HD2  1 
ATOM   3130 H HE1  . PHE A 1 203 ? 14.41400 -24.45100 -12.01700 1.000 92.99000  ? 203 PHE A HE1  1 
ATOM   3131 H HE2  . PHE A 1 203 ? 12.59200 -24.90600 -8.49700  1.000 91.12000  ? 203 PHE A HE2  1 
ATOM   3132 H HZ   . PHE A 1 203 ? 13.27300 -25.77500 -10.52000 1.000 93.53000  ? 203 PHE A HZ   1 
ATOM   3133 N N    . VAL A 1 204 ? 17.62000 -19.09400 -9.25700  1.000 39.99000  ? 204 VAL A N    1 
ATOM   3134 C CA   . VAL A 1 204 ? 18.22200 -17.79700 -9.41200  1.000 48.79000  ? 204 VAL A CA   1 
ATOM   3135 C C    . VAL A 1 204 ? 19.08200 -17.85800 -10.65800 1.000 57.61000  ? 204 VAL A C    1 
ATOM   3136 O O    . VAL A 1 204 ? 20.01600 -18.66300 -10.74200 1.000 67.80000  ? 204 VAL A O    1 
ATOM   3137 C CB   . VAL A 1 204 ? 19.03300 -17.42200 -8.16900  1.000 49.29000  ? 204 VAL A CB   1 
ATOM   3138 C CG1  . VAL A 1 204 ? 19.81300 -16.14300 -8.40300  1.000 47.31000  ? 204 VAL A CG1  1 
ATOM   3139 C CG2  . VAL A 1 204 ? 18.11500 -17.24900 -6.98100  1.000 55.78000  ? 204 VAL A CG2  1 
ATOM   3140 H H    . VAL A 1 204 ? 18.18500 -19.71800 -9.07800  1.000 47.86000  ? 204 VAL A H    1 
ATOM   3141 H HA   . VAL A 1 204 ? 17.54600 -17.11400 -9.54400  1.000 58.43000  ? 204 VAL A HA   1 
ATOM   3142 H HB   . VAL A 1 204 ? 19.66300 -18.13600 -7.98200  1.000 59.02000  ? 204 VAL A HB   1 
ATOM   3143 H HG11 . VAL A 1 204 ? 20.07600 -15.77300 -7.54600  1.000 56.65000  ? 204 VAL A HG11 1 
ATOM   3144 H HG12 . VAL A 1 204 ? 20.60000 -16.34600 -8.93100  1.000 56.65000  ? 204 VAL A HG12 1 
ATOM   3145 H HG13 . VAL A 1 204 ? 19.24900 -15.51200 -8.87700  1.000 56.65000  ? 204 VAL A HG13 1 
ATOM   3146 H HG21 . VAL A 1 204 ? 18.63300 -16.93300 -6.22400  1.000 66.81000  ? 204 VAL A HG21 1 
ATOM   3147 H HG22 . VAL A 1 204 ? 17.42700 -16.60200 -7.20500  1.000 66.81000  ? 204 VAL A HG22 1 
ATOM   3148 H HG23 . VAL A 1 204 ? 17.70800 -18.10400 -6.76900  1.000 66.81000  ? 204 VAL A HG23 1 
ATOM   3149 N N    . ALA A 1 205 ? 18.78300 -16.98100 -11.61000 1.000 61.50000  ? 205 ALA A N    1 
ATOM   3150 C CA   . ALA A 1 205 ? 19.47600 -16.99600 -12.88900 1.000 68.17000  ? 205 ALA A CA   1 
ATOM   3151 C C    . ALA A 1 205 ? 20.95000 -16.64800 -12.76500 1.000 58.07000  ? 205 ALA A C    1 
ATOM   3152 O O    . ALA A 1 205 ? 21.66500 -16.70900 -13.77000 1.000 76.81000  ? 205 ALA A O    1 
ATOM   3153 C CB   . ALA A 1 205 ? 18.82700 -15.99200 -13.85400 1.000 61.66000  ? 205 ALA A CB   1 
ATOM   3154 H H    . ALA A 1 205 ? 18.18400 -16.36800 -11.53900 1.000 73.67000  ? 205 ALA A H    1 
ATOM   3155 H HA   . ALA A 1 205 ? 19.39600 -17.88900 -13.26000 1.000 81.68000  ? 205 ALA A HA   1 
ATOM   3156 H HB1  . ALA A 1 205 ? 19.29000 -16.02800 -14.70500 1.000 73.87000  ? 205 ALA A HB1  1 
ATOM   3157 H HB2  . ALA A 1 205 ? 17.89400 -16.22800 -13.97400 1.000 73.87000  ? 205 ALA A HB2  1 
ATOM   3158 H HB3  . ALA A 1 205 ? 18.89700 -15.10200 -13.47600 1.000 73.87000  ? 205 ALA A HB3  1 
ATOM   3159 N N    . TYR A 1 206 ? 21.40800 -16.22600 -11.58500 1.000 58.46000  ? 206 TYR A N    1 
ATOM   3160 C CA   . TYR A 1 206 ? 22.71300 -15.58900 -11.48300 1.000 43.94000  ? 206 TYR A CA   1 
ATOM   3161 C C    . TYR A 1 206 ? 23.57900 -16.38200 -10.51800 1.000 46.58000  ? 206 TYR A C    1 
ATOM   3162 O O    . TYR A 1 206 ? 23.07200 -17.09600 -9.63600  1.000 51.49000  ? 206 TYR A O    1 
ATOM   3163 C CB   . TYR A 1 206 ? 22.62900 -14.13000 -11.04200 1.000 44.14000  ? 206 TYR A CB   1 
ATOM   3164 C CG   . TYR A 1 206 ? 21.63200 -13.32800 -11.82900 1.000 52.45000  ? 206 TYR A CG   1 
ATOM   3165 C CD1  . TYR A 1 206 ? 21.97200 -12.75000 -13.03600 1.000 54.52000  ? 206 TYR A CD1  1 
ATOM   3166 C CD2  . TYR A 1 206 ? 20.36000 -13.14800 -11.35900 1.000 41.69000  ? 206 TYR A CD2  1 
ATOM   3167 C CE1  . TYR A 1 206 ? 21.07600 -12.00500 -13.74700 1.000 57.65000  ? 206 TYR A CE1  1 
ATOM   3168 C CE2  . TYR A 1 206 ? 19.42700 -12.40800 -12.07800 1.000 64.37000  ? 206 TYR A CE2  1 
ATOM   3169 C CZ   . TYR A 1 206 ? 19.79800 -11.83000 -13.27700 1.000 60.60000  ? 206 TYR A CZ   1 
ATOM   3170 O OH   . TYR A 1 206 ? 18.92400 -11.06000 -14.00700 1.000 57.17000  ? 206 TYR A OH   1 
ATOM   3171 H H    . TYR A 1 206 ? 20.98300 -16.29800 -10.84000 1.000 70.03000  ? 206 TYR A H    1 
ATOM   3172 H HA   . TYR A 1 206 ? 23.13600 -15.57700 -12.35600 1.000 52.60000  ? 206 TYR A HA   1 
ATOM   3173 H HB2  . TYR A 1 206 ? 22.36600 -14.09900 -10.10900 1.000 52.85000  ? 206 TYR A HB2  1 
ATOM   3174 H HB3  . TYR A 1 206 ? 23.50000 -13.71800 -11.15600 1.000 52.85000  ? 206 TYR A HB3  1 
ATOM   3175 H HD1  . TYR A 1 206 ? 22.83000 -12.87100 -13.37300 1.000 65.30000  ? 206 TYR A HD1  1 
ATOM   3176 H HD2  . TYR A 1 206 ? 20.11500 -13.52600 -10.54600 1.000 49.90000  ? 206 TYR A HD2  1 
ATOM   3177 H HE1  . TYR A 1 206 ? 21.33200 -11.61400 -14.55100 1.000 69.06000  ? 206 TYR A HE1  1 
ATOM   3178 H HE2  . TYR A 1 206 ? 18.56200 -12.30300 -11.75500 1.000 77.12000  ? 206 TYR A HE2  1 
ATOM   3179 H HH   . TYR A 1 206 ? 18.16400 -11.07200 -13.65000 1.000 68.48000  ? 206 TYR A HH   1 
ATOM   3180 N N    . PRO A 1 207 ? 24.88300 -16.36500 -10.71700 1.000 57.21000  ? 207 PRO A N    1 
ATOM   3181 C CA   . PRO A 1 207 ? 25.75300 -17.12500 -9.81400  1.000 54.69000  ? 207 PRO A CA   1 
ATOM   3182 C C    . PRO A 1 207 ? 25.66300 -16.51400 -8.42500  1.000 52.41000  ? 207 PRO A C    1 
ATOM   3183 O O    . PRO A 1 207 ? 25.72700 -15.29200 -8.27600  1.000 44.88000  ? 207 PRO A O    1 
ATOM   3184 C CB   . PRO A 1 207 ? 27.13900 -16.97800 -10.44500 1.000 60.02000  ? 207 PRO A CB   1 
ATOM   3185 C CG   . PRO A 1 207 ? 27.06200 -15.65800 -11.19900 1.000 58.60000  ? 207 PRO A CG   1 
ATOM   3186 C CD   . PRO A 1 207 ? 25.61000 -15.42600 -11.59200 1.000 52.76000  ? 207 PRO A CD   1 
ATOM   3187 H HA   . PRO A 1 207 ? 25.53500 -18.07000 -9.78300  1.000 65.51000  ? 207 PRO A HA   1 
ATOM   3188 H HB2  . PRO A 1 207 ? 27.82000 -16.94900 -9.75500  1.000 71.90000  ? 207 PRO A HB2  1 
ATOM   3189 H HB3  . PRO A 1 207 ? 27.31200 -17.71700 -11.04900 1.000 71.90000  ? 207 PRO A HB3  1 
ATOM   3190 H HG2  . PRO A 1 207 ? 27.37100 -14.94300 -10.62100 1.000 70.20000  ? 207 PRO A HG2  1 
ATOM   3191 H HG3  . PRO A 1 207 ? 27.62000 -15.71000 -11.99000 1.000 70.20000  ? 207 PRO A HG3  1 
ATOM   3192 H HD2  . PRO A 1 207 ? 25.34500 -14.51000 -11.41600 1.000 63.19000  ? 207 PRO A HD2  1 
ATOM   3193 H HD3  . PRO A 1 207 ? 25.46500 -15.64000 -12.52700 1.000 63.19000  ? 207 PRO A HD3  1 
ATOM   3194 N N    . ILE A 1 208 ? 25.40700 -17.34700 -7.42800  1.000 44.90000  ? 208 ILE A N    1 
ATOM   3195 C CA   . ILE A 1 208 ? 25.48300 -16.93200 -6.03500  1.000 53.33000  ? 208 ILE A CA   1 
ATOM   3196 C C    . ILE A 1 208 ? 26.84700 -17.39400 -5.54200  1.000 47.10000  ? 208 ILE A C    1 
ATOM   3197 O O    . ILE A 1 208 ? 27.07100 -18.59500 -5.29900  1.000 43.64000  ? 208 ILE A O    1 
ATOM   3198 C CB   . ILE A 1 208 ? 24.35800 -17.51300 -5.18800  1.000 38.65000  ? 208 ILE A CB   1 
ATOM   3199 C CG1  . ILE A 1 208 ? 22.99900 -17.01500 -5.71400  1.000 55.96000  ? 208 ILE A CG1  1 
ATOM   3200 C CG2  . ILE A 1 208 ? 24.54700 -17.12400 -3.75400  1.000 50.22000  ? 208 ILE A CG2  1 
ATOM   3201 C CD1  . ILE A 1 208 ? 21.75900 -17.62500 -5.03900  1.000 54.84000  ? 208 ILE A CD1  1 
ATOM   3202 H H    . ILE A 1 208 ? 25.18300 -18.17100 -7.53500  1.000 53.76000  ? 208 ILE A H    1 
ATOM   3203 H HA   . ILE A 1 208 ? 25.42100 -15.96500 -5.98100  1.000 63.87000  ? 208 ILE A HA   1 
ATOM   3204 H HB   . ILE A 1 208 ? 24.37700 -18.48100 -5.25100  1.000 46.26000  ? 208 ILE A HB   1 
ATOM   3205 H HG12 . ILE A 1 208 ? 22.95500 -16.05500 -5.58300  1.000 67.03000  ? 208 ILE A HG12 1 
ATOM   3206 H HG13 . ILE A 1 208 ? 22.94300 -17.22300 -6.66000  1.000 67.03000  ? 208 ILE A HG13 1 
ATOM   3207 H HG21 . ILE A 1 208 ? 23.71600 -17.26700 -3.27600  1.000 60.14000  ? 208 ILE A HG21 1 
ATOM   3208 H HG22 . ILE A 1 208 ? 25.24900 -17.67100 -3.36900  1.000 60.14000  ? 208 ILE A HG22 1 
ATOM   3209 H HG23 . ILE A 1 208 ? 24.79700 -16.18800 -3.71200  1.000 60.14000  ? 208 ILE A HG23 1 
ATOM   3210 H HD11 . ILE A 1 208 ? 20.96900 -17.37500 -5.54400  1.000 65.69000  ? 208 ILE A HD11 1 
ATOM   3211 H HD12 . ILE A 1 208 ? 21.85000 -18.59100 -5.02500  1.000 65.69000  ? 208 ILE A HD12 1 
ATOM   3212 H HD13 . ILE A 1 208 ? 21.69300 -17.28600 -4.13300  1.000 65.69000  ? 208 ILE A HD13 1 
ATOM   3213 N N    . GLN A 1 209 ? 27.74800 -16.42000 -5.41800  1.000 41.76000  ? 209 GLN A N    1 
ATOM   3214 C CA   . GLN A 1 209 ? 29.11100 -16.65100 -4.96400  1.000 47.62000  ? 209 GLN A CA   1 
ATOM   3215 C C    . GLN A 1 209 ? 29.26300 -16.43400 -3.46300  1.000 43.84000  ? 209 GLN A C    1 
ATOM   3216 O O    . GLN A 1 209 ? 28.80500 -15.43000 -2.91700  1.000 57.63000  ? 209 GLN A O    1 
ATOM   3217 C CB   . GLN A 1 209 ? 30.05300 -15.72300 -5.71100  1.000 36.63000  ? 209 GLN A CB   1 
ATOM   3218 C CG   . GLN A 1 209 ? 29.88700 -15.73300 -7.23000  1.000 43.38000  ? 209 GLN A CG   1 
ATOM   3219 C CD   . GLN A 1 209 ? 30.71800 -14.61400 -7.91100  1.000 44.92000  ? 209 GLN A CD   1 
ATOM   3220 O OE1  . GLN A 1 209 ? 31.12000 -13.62300 -7.27200  1.000 58.18000  ? 209 GLN A OE1  1 
ATOM   3221 N NE2  . GLN A 1 209 ? 30.92400 -14.74800 -9.20700  1.000 55.20000  ? 209 GLN A NE2  1 
ATOM   3222 H H    . GLN A 1 209 ? 27.58600 -15.59500 -5.59600  1.000 49.99000  ? 209 GLN A H    1 
ATOM   3223 H HA   . GLN A 1 209 ? 29.34000 -17.57800 -5.13700  1.000 57.02000  ? 209 GLN A HA   1 
ATOM   3224 H HB2  . GLN A 1 209 ? 29.89700 -14.81500 -5.40600  1.000 43.83000  ? 209 GLN A HB2  1 
ATOM   3225 H HB3  . GLN A 1 209 ? 30.96500 -15.98700 -5.51500  1.000 43.83000  ? 209 GLN A HB3  1 
ATOM   3226 H HG2  . GLN A 1 209 ? 30.18600 -16.58700 -7.57900  1.000 51.93000  ? 209 GLN A HG2  1 
ATOM   3227 H HG3  . GLN A 1 209 ? 28.95300 -15.59300 -7.45100  1.000 51.93000  ? 209 GLN A HG3  1 
ATOM   3228 H HE21 . GLN A 1 209 ? 30.60200 -15.42700 -9.62600  1.000 66.11000  ? 209 GLN A HE21 1 
ATOM   3229 H HE22 . GLN A 1 209 ? 31.37800 -14.15600 -9.63400  1.000 66.11000  ? 209 GLN A HE22 1 
ATOM   3230 N N    . LEU A 1 210 ? 29.94500 -17.35600 -2.81100  1.000 49.19000  ? 210 LEU A N    1 
ATOM   3231 C CA   . LEU A 1 210 ? 30.22900 -17.27200 -1.38400  1.000 46.16000  ? 210 LEU A CA   1 
ATOM   3232 C C    . LEU A 1 210 ? 31.73600 -17.09700 -1.21400  1.000 48.31000  ? 210 LEU A C    1 
ATOM   3233 O O    . LEU A 1 210 ? 32.50200 -17.81400 -1.86500  1.000 48.01000  ? 210 LEU A O    1 
ATOM   3234 C CB   . LEU A 1 210 ? 29.72500 -18.54300 -0.67900  1.000 42.38000  ? 210 LEU A CB   1 
ATOM   3235 C CG   . LEU A 1 210 ? 30.04100 -18.63100 0.81100   1.000 54.97000  ? 210 LEU A CG   1 
ATOM   3236 C CD1  . LEU A 1 210 ? 29.38500 -17.54500 1.67100   1.000 52.85000  ? 210 LEU A CD1  1 
ATOM   3237 C CD2  . LEU A 1 210 ? 29.60300 -20.00400 1.32100   1.000 65.74000  ? 210 LEU A CD2  1 
ATOM   3238 H H    . LEU A 1 210 ? 30.26600 -18.06300 -3.18200  1.000 58.91000  ? 210 LEU A H    1 
ATOM   3239 H HA   . LEU A 1 210 ? 29.79000 -16.51000 -0.97300  1.000 55.27000  ? 210 LEU A HA   1 
ATOM   3240 H HB2  . LEU A 1 210 ? 28.76000 -18.58200 -0.77400  1.000 50.73000  ? 210 LEU A HB2  1 
ATOM   3241 H HB3  . LEU A 1 210 ? 30.13200 -19.31100 -1.10800  1.000 50.73000  ? 210 LEU A HB3  1 
ATOM   3242 H HG   . LEU A 1 210 ? 30.99600 -18.49600 0.90600   1.000 65.84000  ? 210 LEU A HG   1 
ATOM   3243 H HD11 . LEU A 1 210 ? 29.64100 -17.67700 2.59700   1.000 63.30000  ? 210 LEU A HD11 1 
ATOM   3244 H HD12 . LEU A 1 210 ? 29.68700 -16.67500 1.36600   1.000 63.30000  ? 210 LEU A HD12 1 
ATOM   3245 H HD13 . LEU A 1 210 ? 28.42100 -17.61100 1.58300   1.000 63.30000  ? 210 LEU A HD13 1 
ATOM   3246 H HD21 . LEU A 1 210 ? 29.82200 -20.07500 2.26300   1.000 78.77000  ? 210 LEU A HD21 1 
ATOM   3247 H HD22 . LEU A 1 210 ? 28.64600 -20.09700 1.19500   1.000 78.77000  ? 210 LEU A HD22 1 
ATOM   3248 H HD23 . LEU A 1 210 ? 30.07100 -20.69000 0.82000   1.000 78.77000  ? 210 LEU A HD23 1 
ATOM   3249 N N    . VAL A 1 211 ? 32.15500 -16.07600 -0.44300  1.000 42.69000  ? 211 VAL A N    1 
ATOM   3250 C CA   . VAL A 1 211 ? 33.56400 -15.74300 -0.24700  1.000 44.22000  ? 211 VAL A CA   1 
ATOM   3251 C C    . VAL A 1 211 ? 33.98800 -16.39400 1.05400   1.000 46.33000  ? 211 VAL A C    1 
ATOM   3252 O O    . VAL A 1 211 ? 33.36800 -16.17500 2.09200   1.000 53.81000  ? 211 VAL A O    1 
ATOM   3253 C CB   . VAL A 1 211 ? 33.80300 -14.22200 -0.20500  1.000 64.54000  ? 211 VAL A CB   1 
ATOM   3254 C CG1  . VAL A 1 211 ? 35.17600 -13.94000 0.32400   1.000 36.65000  ? 211 VAL A CG1  1 
ATOM   3255 C CG2  . VAL A 1 211 ? 33.64600 -13.67000 -1.57100  1.000 36.45000  ? 211 VAL A CG2  1 
ATOM   3256 H H    . VAL A 1 211 ? 31.62200 -15.55400 -0.01600  1.000 51.11000  ? 211 VAL A H    1 
ATOM   3257 H HA   . VAL A 1 211 ? 34.08900 -16.10000 -0.98000  1.000 52.94000  ? 211 VAL A HA   1 
ATOM   3258 H HB   . VAL A 1 211 ? 33.15900 -13.79600 0.38200   1.000 77.33000  ? 211 VAL A HB   1 
ATOM   3259 H HG11 . VAL A 1 211 ? 35.43200 -13.03800 0.07400   1.000 43.85000  ? 211 VAL A HG11 1 
ATOM   3260 H HG12 . VAL A 1 211 ? 35.16500 -14.02400 1.29000   1.000 43.85000  ? 211 VAL A HG12 1 
ATOM   3261 H HG13 . VAL A 1 211 ? 35.79900 -14.57800 -0.05700  1.000 43.85000  ? 211 VAL A HG13 1 
ATOM   3262 H HG21 . VAL A 1 211 ? 33.76700 -12.70800 -1.53800  1.000 43.62000  ? 211 VAL A HG21 1 
ATOM   3263 H HG22 . VAL A 1 211 ? 34.31500 -14.06800 -2.15100  1.000 43.62000  ? 211 VAL A HG22 1 
ATOM   3264 H HG23 . VAL A 1 211 ? 32.75800 -13.88100 -1.89700  1.000 43.62000  ? 211 VAL A HG23 1 
ATOM   3265 N N    . VAL A 1 212 ? 35.00200 -17.23000 1.01900   1.000 54.42000  ? 212 VAL A N    1 
ATOM   3266 C CA   . VAL A 1 212 ? 35.43400 -17.94000 2.21800   1.000 75.60000  ? 212 VAL A CA   1 
ATOM   3267 C C    . VAL A 1 212 ? 36.94400 -17.75600 2.40800   1.000 47.71000  ? 212 VAL A C    1 
ATOM   3268 O O    . VAL A 1 212 ? 37.73300 -17.79000 1.44800   1.000 38.22000  ? 212 VAL A O    1 
ATOM   3269 C CB   . VAL A 1 212 ? 35.01700 -19.42800 2.17200   1.000 74.67000  ? 212 VAL A CB   1 
ATOM   3270 C CG1  . VAL A 1 212 ? 35.35500 -20.04300 0.82500   1.000 56.68000  ? 212 VAL A CG1  1 
ATOM   3271 C CG2  . VAL A 1 212 ? 35.66500 -20.17700 3.30800   1.000 80.43000  ? 212 VAL A CG2  1 
ATOM   3272 H H    . VAL A 1 212 ? 35.46200 -17.40700 0.31400   1.000 65.18000  ? 212 VAL A H    1 
ATOM   3273 H HA   . VAL A 1 212 ? 35.01800 -17.54100 2.99800   1.000 90.59000  ? 212 VAL A HA   1 
ATOM   3274 H HB   . VAL A 1 212 ? 34.05600 -19.49900 2.28000   1.000 89.48000  ? 212 VAL A HB   1 
ATOM   3275 H HG11 . VAL A 1 212 ? 35.07300 -20.97100 0.82100   1.000 67.90000  ? 212 VAL A HG11 1 
ATOM   3276 H HG12 . VAL A 1 212 ? 34.89000 -19.55400 0.12800   1.000 67.90000  ? 212 VAL A HG12 1 
ATOM   3277 H HG13 . VAL A 1 212 ? 36.31300 -19.98800 0.68300   1.000 67.90000  ? 212 VAL A HG13 1 
ATOM   3278 H HG21 . VAL A 1 212 ? 35.39100 -21.10600 3.27100   1.000 96.39000  ? 212 VAL A HG21 1 
ATOM   3279 H HG22 . VAL A 1 212 ? 36.62900 -20.11200 3.21900   1.000 96.39000  ? 212 VAL A HG22 1 
ATOM   3280 H HG23 . VAL A 1 212 ? 35.38300 -19.78200 4.14800   1.000 96.39000  ? 212 VAL A HG23 1 
ATOM   3281 N N    . THR A 1 213 ? 37.31400 -17.44900 3.62200   1.000 61.32000  ? 213 THR A N    1 
ATOM   3282 C CA   . THR A 1 213 ? 38.68600 -17.21800 4.02100   1.000 50.68000  ? 213 THR A CA   1 
ATOM   3283 C C    . THR A 1 213 ? 39.10900 -18.48200 4.77600   1.000 51.23000  ? 213 THR A C    1 
ATOM   3284 O O    . THR A 1 213 ? 38.69000 -18.69600 5.91100   1.000 65.81000  ? 213 THR A O    1 
ATOM   3285 C CB   . THR A 1 213 ? 38.75400 -15.94400 4.86900   1.000 44.91000  ? 213 THR A CB   1 
ATOM   3286 O OG1  . THR A 1 213 ? 38.08700 -14.84900 4.22500   1.000 48.80000  ? 213 THR A OG1  1 
ATOM   3287 C CG2  . THR A 1 213 ? 40.23600 -15.48200 5.09900   1.000 56.34000  ? 213 THR A CG2  1 
ATOM   3288 H H    . THR A 1 213 ? 36.76200 -17.36300 4.27500   1.000 73.46000  ? 213 THR A H    1 
ATOM   3289 H HA   . THR A 1 213 ? 39.28500 -17.09600 3.26800   1.000 60.69000  ? 213 THR A HA   1 
ATOM   3290 H HB   . THR A 1 213 ? 38.32900 -16.15300 5.71500   1.000 53.77000  ? 213 THR A HB   1 
ATOM   3291 H HG1  . THR A 1 213 ? 37.27100 -15.02400 4.13100   1.000 58.44000  ? 213 THR A HG1  1 
ATOM   3292 H HG21 . THR A 1 213 ? 40.25200 -14.56900 5.42700   1.000 67.48000  ? 213 THR A HG21 1 
ATOM   3293 H HG22 . THR A 1 213 ? 40.66600 -16.05800 5.75000   1.000 67.48000  ? 213 THR A HG22 1 
ATOM   3294 H HG23 . THR A 1 213 ? 40.73000 -15.52500 4.26500   1.000 67.48000  ? 213 THR A HG23 1 
ATOM   3295 N N    . LYS A 1 214 ? 39.90800 -19.33200 4.12800   1.000 52.71000  ? 214 LYS A N    1 
ATOM   3296 C CA   . LYS A 1 214 ? 40.50800 -20.52800 4.71300   1.000 59.73000  ? 214 LYS A CA   1 
ATOM   3297 C C    . LYS A 1 214 ? 42.01100 -20.31600 4.96200   1.000 82.48000  ? 214 LYS A C    1 
ATOM   3298 O O    . LYS A 1 214 ? 42.74500 -19.80800 4.10500   1.000 73.93000  ? 214 LYS A O    1 
ATOM   3299 C CB   . LYS A 1 214 ? 40.31200 -21.75800 3.79100   1.000 55.07000  ? 214 LYS A CB   1 
ATOM   3300 H H    . LYS A 1 214 ? 40.12800 -19.23000 3.30300   1.000 63.13000  ? 214 LYS A H    1 
ATOM   3301 H HA   . LYS A 1 214 ? 40.08200 -20.70400 5.56700   1.000 71.55000  ? 214 LYS A HA   1 
ATOM   3302 N N    . GLU A 1 215 ? 42.48300 -20.72500 6.12700   1.000 80.02000  ? 215 GLU A N    1 
ATOM   3303 C CA   . GLU A 1 215 ? 43.90100 -20.62100 6.43300   1.000 52.26000  ? 215 GLU A CA   1 
ATOM   3304 C C    . GLU A 1 215 ? 44.68500 -21.73700 5.74400   1.000 54.64000  ? 215 GLU A C    1 
ATOM   3305 O O    . GLU A 1 215 ? 44.23100 -22.86800 5.62300   1.000 61.94000  ? 215 GLU A O    1 
ATOM   3306 C CB   . GLU A 1 215 ? 44.08900 -20.63200 7.94800   1.000 68.63000  ? 215 GLU A CB   1 
ATOM   3307 C CG   . GLU A 1 215 ? 45.31800 -21.32700 8.47600   1.000 92.03000  ? 215 GLU A CG   1 
ATOM   3308 C CD   . GLU A 1 215 ? 45.71300 -20.78300 9.84200   1.000 92.49000  ? 215 GLU A CD   1 
ATOM   3309 O OE1  . GLU A 1 215 ? 44.81000 -20.27700 10.55900  1.000 85.51000  ? 215 GLU A OE1  1 
ATOM   3310 O OE2  . GLU A 1 215 ? 46.92100 -20.86100 10.18200  1.000 91.12000  ? 215 GLU A OE2  1 
ATOM   3311 H H    . GLU A 1 215 ? 42.00600 -21.06600 6.75700   1.000 95.90000  ? 215 GLU A H    1 
ATOM   3312 H HA   . GLU A 1 215 ? 44.26800 -19.78800 6.09900   1.000 62.59000  ? 215 GLU A HA   1 
ATOM   3313 H HB2  . GLU A 1 215 ? 44.13200 -19.71200 8.25200   1.000 82.24000  ? 215 GLU A HB2  1 
ATOM   3314 H HB3  . GLU A 1 215 ? 43.32200 -21.07700 8.34200   1.000 82.24000  ? 215 GLU A HB3  1 
ATOM   3315 H HG2  . GLU A 1 215 ? 45.13900 -22.27600 8.56500   1.000 110.31000 ? 215 GLU A HG2  1 
ATOM   3316 H HG3  . GLU A 1 215 ? 46.05700 -21.18400 7.86400   1.000 110.31000 ? 215 GLU A HG3  1 
ATOM   3317 N N    . VAL A 1 216 ? 45.82700 -21.37500 5.17900   1.000 64.14000  ? 216 VAL A N    1 
ATOM   3318 C CA   . VAL A 1 216 ? 46.64800 -22.34600 4.47400   1.000 59.37000  ? 216 VAL A CA   1 
ATOM   3319 C C    . VAL A 1 216 ? 47.48700 -23.07400 5.51000   1.000 74.28000  ? 216 VAL A C    1 
ATOM   3320 O O    . VAL A 1 216 ? 48.28200 -22.44800 6.21400   1.000 77.69000  ? 216 VAL A O    1 
ATOM   3321 C CB   . VAL A 1 216 ? 47.53400 -21.66000 3.42900   1.000 60.66000  ? 216 VAL A CB   1 
ATOM   3322 C CG1  . VAL A 1 216 ? 48.48900 -22.65000 2.73500   1.000 69.57000  ? 216 VAL A CG1  1 
ATOM   3323 C CG2  . VAL A 1 216 ? 46.68100 -20.98800 2.41200   1.000 63.14000  ? 216 VAL A CG2  1 
ATOM   3324 H H    . VAL A 1 216 ? 46.14700 -20.57700 5.18900   1.000 76.84000  ? 216 VAL A H    1 
ATOM   3325 H HA   . VAL A 1 216 ? 46.08300 -22.98800 4.01500   1.000 71.12000  ? 216 VAL A HA   1 
ATOM   3326 H HB   . VAL A 1 216 ? 48.08300 -21.00300 3.88500   1.000 72.66000  ? 216 VAL A HB   1 
ATOM   3327 H HG11 . VAL A 1 216 ? 48.89600 -22.21400 1.97100   1.000 83.36000  ? 216 VAL A HG11 1 
ATOM   3328 H HG12 . VAL A 1 216 ? 49.17400 -22.92200 3.36500   1.000 83.36000  ? 216 VAL A HG12 1 
ATOM   3329 H HG13 . VAL A 1 216 ? 47.98200 -23.42400 2.44300   1.000 83.36000  ? 216 VAL A HG13 1 
ATOM   3330 H HG21 . VAL A 1 216 ? 47.24700 -20.62800 1.71200   1.000 75.64000  ? 216 VAL A HG21 1 
ATOM   3331 H HG22 . VAL A 1 216 ? 46.06400 -21.63700 2.03900   1.000 75.64000  ? 216 VAL A HG22 1 
ATOM   3332 H HG23 . VAL A 1 216 ? 46.18700 -20.27100 2.83900   1.000 75.64000  ? 216 VAL A HG23 1 
ATOM   3333 N N    . GLU A 1 217 ? 47.32400 -24.39100 5.58900   1.000 99.74000  ? 217 GLU A N    1 
ATOM   3334 C CA   . GLU A 1 217 ? 48.02200 -25.22900 6.55700   1.000 97.85000  ? 217 GLU A CA   1 
ATOM   3335 C C    . GLU A 1 217 ? 49.11200 -26.00700 5.83600   1.000 103.96000 ? 217 GLU A C    1 
ATOM   3336 O O    . GLU A 1 217 ? 48.86100 -26.57800 4.76500   1.000 95.79000  ? 217 GLU A O    1 
ATOM   3337 C CB   . GLU A 1 217 ? 47.05000 -26.19000 7.24100   1.000 110.71000 ? 217 GLU A CB   1 
ATOM   3338 C CG   . GLU A 1 217 ? 47.31700 -26.37100 8.73500   1.000 116.16000 ? 217 GLU A CG   1 
ATOM   3339 C CD   . GLU A 1 217 ? 46.63900 -25.30200 9.59600   1.000 108.03000 ? 217 GLU A CD   1 
ATOM   3340 O OE1  . GLU A 1 217 ? 45.40400 -25.15500 9.48700   1.000 97.25000  ? 217 GLU A OE1  1 
ATOM   3341 O OE2  . GLU A 1 217 ? 47.32700 -24.58000 10.36600  1.000 96.11000  ? 217 GLU A OE2  1 
ATOM   3342 H H    . GLU A 1 217 ? 46.79600 -24.83500 5.07600   1.000 119.56000 ? 217 GLU A H    1 
ATOM   3343 H HA   . GLU A 1 217 ? 48.43500 -24.67700 7.23900   1.000 117.30000 ? 217 GLU A HA   1 
ATOM   3344 H HB2  . GLU A 1 217 ? 46.14800 -25.84600 7.14000   1.000 132.73000 ? 217 GLU A HB2  1 
ATOM   3345 H HB3  . GLU A 1 217 ? 47.12100 -27.06000 6.81900   1.000 132.73000 ? 217 GLU A HB3  1 
ATOM   3346 H HG2  . GLU A 1 217 ? 46.98100 -27.23700 9.01300   1.000 139.27000 ? 217 GLU A HG2  1 
ATOM   3347 H HG3  . GLU A 1 217 ? 48.27300 -26.32000 8.89200   1.000 139.27000 ? 217 GLU A HG3  1 
HETATM 3348 F F17  . 990 B 2 .   ? 11.05200 -1.40000  1.05400   1.000 47.62000  ? 301 990 A F17  1 
HETATM 3349 C C16  . 990 B 2 .   ? 12.06000 -1.48900  0.14000   1.000 49.26000  ? 301 990 A C16  1 
HETATM 3350 C C18  . 990 B 2 .   ? 13.24800 -0.88100  0.49700   1.000 52.38000  ? 301 990 A C18  1 
HETATM 3351 C C8   . 990 B 2 .   ? 14.36900 -0.92500  -0.29700  1.000 45.86000  ? 301 990 A C8   1 
HETATM 3352 C C21  . 990 B 2 .   ? 15.64100 -0.24200  0.26200   1.000 54.78000  ? 301 990 A C21  1 
HETATM 3353 N N26  . 990 B 2 .   ? 16.84500 -0.81600  0.01400   1.000 32.01000  ? 301 990 A N26  1 
HETATM 3354 C C25  . 990 B 2 .   ? 17.95800 -0.25800  0.46400   1.000 57.28000  ? 301 990 A C25  1 
HETATM 3355 O O27  . 990 B 2 .   ? 19.13300 -0.92800  0.12000   1.000 42.15000  ? 301 990 A O27  1 
HETATM 3356 C C28  . 990 B 2 .   ? 18.97700 -2.05300  -0.68900  1.000 56.60000  ? 301 990 A C28  1 
HETATM 3357 C C24  . 990 B 2 .   ? 17.92400 0.90100   1.25400   1.000 65.96000  ? 301 990 A C24  1 
HETATM 3358 C C23  . 990 B 2 .   ? 16.71800 1.47000   1.54300   1.000 54.62000  ? 301 990 A C23  1 
HETATM 3359 C C22  . 990 B 2 .   ? 15.57300 0.88700   1.07700   1.000 48.18000  ? 301 990 A C22  1 
HETATM 3360 C C19  . 990 B 2 .   ? 11.94100 -2.16200  -1.07200  1.000 31.95000  ? 301 990 A C19  1 
HETATM 3361 C C20  . 990 B 2 .   ? 13.03900 -2.17900  -1.91600  1.000 38.93000  ? 301 990 A C20  1 
HETATM 3362 C C7   . 990 B 2 .   ? 14.26700 -1.55800  -1.54500  1.000 40.12000  ? 301 990 A C7   1 
HETATM 3363 C C6   . 990 B 2 .   ? 15.47600 -1.65000  -2.50600  1.000 38.99000  ? 301 990 A C6   1 
HETATM 3364 N N9   . 990 B 2 .   ? 15.10600 -1.11900  -3.85600  1.000 36.46000  ? 301 990 A N9   1 
HETATM 3365 C C1   . 990 B 2 .   ? 15.94300 -1.56200  -4.92500  1.000 36.64000  ? 301 990 A C1   1 
HETATM 3366 O O2   . 990 B 2 .   ? 15.67600 -1.20400  -6.05600  1.000 56.04000  ? 301 990 A O2   1 
HETATM 3367 C C5   . 990 B 2 .   ? 15.83000 -3.10100  -2.65600  1.000 47.01000  ? 301 990 A C5   1 
HETATM 3368 C C4   . 990 B 2 .   ? 17.04000 -3.31100  -3.53900  1.000 43.17000  ? 301 990 A C4   1 
HETATM 3369 N N15  . 990 B 2 .   ? 17.98800 -4.17200  -3.21600  1.000 49.86000  ? 301 990 A N15  1 
HETATM 3370 C C13  . 990 B 2 .   ? 19.04800 -4.28500  -4.01800  1.000 47.15000  ? 301 990 A C13  1 
HETATM 3371 N N14  . 990 B 2 .   ? 19.96700 -5.26800  -3.64200  1.000 41.25000  ? 301 990 A N14  1 
HETATM 3372 N N12  . 990 B 2 .   ? 19.20500 -3.55700  -5.14100  1.000 40.00000  ? 301 990 A N12  1 
HETATM 3373 C C10  . 990 B 2 .   ? 18.23600 -2.69100  -5.47100  1.000 39.88000  ? 301 990 A C10  1 
HETATM 3374 C C3   . 990 B 2 .   ? 17.14300 -2.54500  -4.64100  1.000 38.60000  ? 301 990 A C3   1 
HETATM 3375 C C11  . 990 B 2 .   ? 18.38400 -1.79400  -6.71300  1.000 45.45000  ? 301 990 A C11  1 
HETATM 3376 H H1   . 990 B 2 .   ? 13.29900 -0.35100  1.44000   1.000 62.74000  ? 301 990 A H1   1 
HETATM 3377 H H2   . 990 B 2 .   ? 18.47700 -1.77000  -1.61100  1.000 67.79000  ? 301 990 A H2   1 
HETATM 3378 H H3   . 990 B 2 .   ? 18.38000 -2.79500  -0.16700  1.000 67.79000  ? 301 990 A H3   1 
HETATM 3379 H H4   . 990 B 2 .   ? 19.95300 -2.47100  -0.92000  1.000 67.79000  ? 301 990 A H4   1 
HETATM 3380 H H5   . 990 B 2 .   ? 18.84100 1.33800   1.62900   1.000 79.02000  ? 301 990 A H5   1 
HETATM 3381 H H6   . 990 B 2 .   ? 16.66800 2.37500   2.13600   1.000 65.42000  ? 301 990 A H6   1 
HETATM 3382 H H7   . 990 B 2 .   ? 14.60900 1.30400   1.34200   1.000 57.69000  ? 301 990 A H7   1 
HETATM 3383 H H8   . 990 B 2 .   ? 11.01800 -2.65700  -1.34800  1.000 38.21000  ? 301 990 A H8   1 
HETATM 3384 H H9   . 990 B 2 .   ? 12.96300 -2.67500  -2.87600  1.000 46.59000  ? 301 990 A H9   1 
HETATM 3385 H H10  . 990 B 2 .   ? 16.27900 -1.06400  -2.07700  1.000 46.67000  ? 301 990 A H10  1 
HETATM 3386 H H11  . 990 B 2 .   ? 14.33100 -0.50200  -3.99800  1.000 43.63000  ? 301 990 A H11  1 
HETATM 3387 H H12  . 990 B 2 .   ? 14.98600 -3.61600  -3.10300  1.000 56.29000  ? 301 990 A H12  1 
HETATM 3388 H H13  . 990 B 2 .   ? 16.04900 -3.50500  -1.67300  1.000 56.29000  ? 301 990 A H13  1 
HETATM 3389 H H14  . 990 B 2 .   ? 20.24600 -5.32800  -2.68600  1.000 49.37000  ? 301 990 A H14  1 
HETATM 3390 H H15  . 990 B 2 .   ? 20.31700 -5.91600  -4.33600  1.000 49.37000  ? 301 990 A H15  1 
HETATM 3391 H H16  . 990 B 2 .   ? 18.42400 -0.75300  -6.40400  1.000 54.42000  ? 301 990 A H16  1 
HETATM 3392 H H17  . 990 B 2 .   ? 17.53300 -1.94400  -7.37100  1.000 54.42000  ? 301 990 A H17  1 
HETATM 3393 H H18  . 990 B 2 .   ? 19.29800 -2.05100  -7.23800  1.000 54.42000  ? 301 990 A H18  1 
HETATM 3394 O O    . HOH C 3 .   ? 24.98200 5.78900   -7.37300  1.000 46.71000  ? 401 HOH A O    1 
HETATM 3395 O O    . HOH C 3 .   ? 21.58600 -3.13300  -6.76900  1.000 31.99000  ? 402 HOH A O    1 
HETATM 3396 O O    . HOH C 3 .   ? 28.67400 -4.86500  -23.26100 1.000 58.94000  ? 403 HOH A O    1 
HETATM 3397 O O    . HOH C 3 .   ? 23.35200 1.63100   -12.97400 1.000 53.99000  ? 404 HOH A O    1 
HETATM 3398 O O    . HOH C 3 .   ? 16.21200 -16.07500 -3.30300  1.000 46.84000  ? 405 HOH A O    1 
HETATM 3399 O O    . HOH C 3 .   ? 22.72400 -7.30400  -2.77800  1.000 32.10000  ? 406 HOH A O    1 
HETATM 3400 O O    . HOH C 3 .   ? 30.24800 15.76500  1.37900   1.000 54.39000  ? 407 HOH A O    1 
HETATM 3401 O O    . HOH C 3 .   ? 16.98700 -15.02300 -10.89200 1.000 46.28000  ? 408 HOH A O    1 
HETATM 3402 O O    . HOH C 3 .   ? 20.25300 -7.35900  -1.78600  1.000 33.39000  ? 409 HOH A O    1 
HETATM 3403 O O    . HOH C 3 .   ? 21.36900 16.49400  7.41000   1.000 51.48000  ? 410 HOH A O    1 
HETATM 3404 O O    . HOH C 3 .   ? 25.89300 -3.73600  16.08500  1.000 67.50000  ? 411 HOH A O    1 
HETATM 3405 O O    . HOH C 3 .   ? 18.22600 -5.54600  -0.69700  1.000 37.49000  ? 412 HOH A O    1 
HETATM 3406 O O    . HOH C 3 .   ? 12.30500 -5.21900  -0.57100  1.000 39.28000  ? 413 HOH A O    1 
HETATM 3407 O O    . HOH C 3 .   ? 31.89900 8.03000   -5.94000  1.000 53.29000  ? 414 HOH A O    1 
HETATM 3408 O O    . HOH C 3 .   ? 29.02600 15.42300  -1.27300  1.000 46.60000  ? 415 HOH A O    1 
# 
