data_9MM2
# 
_entry.id   9MM2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MM2         pdb_00009mm2 10.2210/pdb9mm2/pdb 
WWPDB D_1000291276 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.country'                 
2 2 'Structure model' '_citation.journal_abbrev'          
3 2 'Structure model' '_citation.journal_id_CSD'          
4 2 'Structure model' '_citation.journal_id_ISSN'         
5 2 'Structure model' '_citation.journal_volume'          
6 2 'Structure model' '_citation.pdbx_database_id_DOI'    
7 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8 2 'Structure model' '_citation.title'                   
9 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MM2 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              vince.carbone@agresearch.co.nz 
_pdbx_contact_author.name_first         vincenzo 
_pdbx_contact_author.name_last          carbone 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4231-2785 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Carbone, V.'   1 0000-0003-4231-2785 
'Reilly, K.'    2 0000-0002-0464-8811 
'Sang, C.'      3 0000-0003-4368-1558 
'Schofield, L.' 4 0000-0001-7288-2792 
'Ronimus, R.'   5 0000-0001-8669-5840 
'Attwood, G.T.' 6 0000-0002-6443-8760 
'Palevich, N.'  7 0000-0002-2101-2452 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CH 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biomolecules 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2218-273X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Crystal Structure of the Multidomain Pectin Methylesterase PmeC5 from Butyrivibrio fibrisolvens D1 T.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.3390/biom15050720 
_citation.pdbx_database_id_PubMed   40427613 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Carbone, V.'     1 0000-0003-4231-2785 
primary 'Reilly, K.'      2 ?                   
primary 'Sang, C.'        3 0000-0003-4368-1558 
primary 'Schofield, L.R.' 4 0000-0001-7288-2792 
primary 'Kelly, W.J.'     5 ?                   
primary 'Ronimus, R.S.'   6 ?                   
primary 'Attwood, G.T.'   7 ?                   
primary 'Palevich, N.'    8 0000-0002-2101-2452 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Putative cell wall binding repeat-containing protein' 49375.812 1   ? ? ? ? 
2 non-polymer syn 'MAGNESIUM ION'                                        24.305    3   ? ? ? ? 
3 non-polymer syn 'SODIUM ION'                                           22.990    3   ? ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                                         62.068    9   ? ? ? ? 
5 non-polymer syn 'AMMONIUM ION'                                         18.038    1   ? ? ? ? 
6 water       nat water                                                  18.015    676 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMLEMKKASEESKIAYSEIITVGTDKDYKTISDAIEAIRHMERDDSQRVTIKIDPGNYQEM
LIVDVDNVSLVNAAGDDASIELADSGVSVSDKAVRITSYYGHGYTYYSMGEDYRYDEEVLKVNQENGYPSVTNPGSGTAT
MWNATVYVNADGFEAEGIIFENSFNQYVSELAAEDTIVAMEGAKEGSDGTRNDLEKGSTVVQQKSYVERASALALGNNLS
DIVFTNCKVVGRQDTLYGGKMTYAEFNNCEIYGAVDYIFGGMTAIFYQCELKFNTTDNKNDVGYITAAQQSSGRGYLMYE
CHITSVEAGTDVDSKYYSYTTSKPGYFGRPWQANTSEVVFYNTTIDECDSTLASTYGSSSLIQPAGWLNSLGGEAQMYEY
GTTESSGVDNSSARIASWTTWTTSDSVLTTPYLADGTKITLDAFRKNKSG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMLEMKKASEESKIAYSEIITVGTDKDYKTISDAIEAIRHMERDDSQRVTIKIDPGNYQEM
LIVDVDNVSLVNAAGDDASIELADSGVSVSDKAVRITSYYGHGYTYYSMGEDYRYDEEVLKVNQENGYPSVTNPGSGTAT
MWNATVYVNADGFEAEGIIFENSFNQYVSELAAEDTIVAMEGAKEGSDGTRNDLEKGSTVVQQKSYVERASALALGNNLS
DIVFTNCKVVGRQDTLYGGKMTYAEFNNCEIYGAVDYIFGGMTAIFYQCELKFNTTDNKNDVGYITAAQQSSGRGYLMYE
CHITSVEAGTDVDSKYYSYTTSKPGYFGRPWQANTSEVVFYNTTIDECDSTLASTYGSSSLIQPAGWLNSLGGEAQMYEY
GTTESSGVDNSSARIASWTTWTTSDSVLTTPYLADGTKITLDAFRKNKSG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'MAGNESIUM ION' MG  
3 'SODIUM ION'    NA  
4 1,2-ETHANEDIOL  EDO 
5 'AMMONIUM ION'  NH4 
6 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  LEU n 
1 23  GLU n 
1 24  MET n 
1 25  LYS n 
1 26  LYS n 
1 27  ALA n 
1 28  SER n 
1 29  GLU n 
1 30  GLU n 
1 31  SER n 
1 32  LYS n 
1 33  ILE n 
1 34  ALA n 
1 35  TYR n 
1 36  SER n 
1 37  GLU n 
1 38  ILE n 
1 39  ILE n 
1 40  THR n 
1 41  VAL n 
1 42  GLY n 
1 43  THR n 
1 44  ASP n 
1 45  LYS n 
1 46  ASP n 
1 47  TYR n 
1 48  LYS n 
1 49  THR n 
1 50  ILE n 
1 51  SER n 
1 52  ASP n 
1 53  ALA n 
1 54  ILE n 
1 55  GLU n 
1 56  ALA n 
1 57  ILE n 
1 58  ARG n 
1 59  HIS n 
1 60  MET n 
1 61  GLU n 
1 62  ARG n 
1 63  ASP n 
1 64  ASP n 
1 65  SER n 
1 66  GLN n 
1 67  ARG n 
1 68  VAL n 
1 69  THR n 
1 70  ILE n 
1 71  LYS n 
1 72  ILE n 
1 73  ASP n 
1 74  PRO n 
1 75  GLY n 
1 76  ASN n 
1 77  TYR n 
1 78  GLN n 
1 79  GLU n 
1 80  MET n 
1 81  LEU n 
1 82  ILE n 
1 83  VAL n 
1 84  ASP n 
1 85  VAL n 
1 86  ASP n 
1 87  ASN n 
1 88  VAL n 
1 89  SER n 
1 90  LEU n 
1 91  VAL n 
1 92  ASN n 
1 93  ALA n 
1 94  ALA n 
1 95  GLY n 
1 96  ASP n 
1 97  ASP n 
1 98  ALA n 
1 99  SER n 
1 100 ILE n 
1 101 GLU n 
1 102 LEU n 
1 103 ALA n 
1 104 ASP n 
1 105 SER n 
1 106 GLY n 
1 107 VAL n 
1 108 SER n 
1 109 VAL n 
1 110 SER n 
1 111 ASP n 
1 112 LYS n 
1 113 ALA n 
1 114 VAL n 
1 115 ARG n 
1 116 ILE n 
1 117 THR n 
1 118 SER n 
1 119 TYR n 
1 120 TYR n 
1 121 GLY n 
1 122 HIS n 
1 123 GLY n 
1 124 TYR n 
1 125 THR n 
1 126 TYR n 
1 127 TYR n 
1 128 SER n 
1 129 MET n 
1 130 GLY n 
1 131 GLU n 
1 132 ASP n 
1 133 TYR n 
1 134 ARG n 
1 135 TYR n 
1 136 ASP n 
1 137 GLU n 
1 138 GLU n 
1 139 VAL n 
1 140 LEU n 
1 141 LYS n 
1 142 VAL n 
1 143 ASN n 
1 144 GLN n 
1 145 GLU n 
1 146 ASN n 
1 147 GLY n 
1 148 TYR n 
1 149 PRO n 
1 150 SER n 
1 151 VAL n 
1 152 THR n 
1 153 ASN n 
1 154 PRO n 
1 155 GLY n 
1 156 SER n 
1 157 GLY n 
1 158 THR n 
1 159 ALA n 
1 160 THR n 
1 161 MET n 
1 162 TRP n 
1 163 ASN n 
1 164 ALA n 
1 165 THR n 
1 166 VAL n 
1 167 TYR n 
1 168 VAL n 
1 169 ASN n 
1 170 ALA n 
1 171 ASP n 
1 172 GLY n 
1 173 PHE n 
1 174 GLU n 
1 175 ALA n 
1 176 GLU n 
1 177 GLY n 
1 178 ILE n 
1 179 ILE n 
1 180 PHE n 
1 181 GLU n 
1 182 ASN n 
1 183 SER n 
1 184 PHE n 
1 185 ASN n 
1 186 GLN n 
1 187 TYR n 
1 188 VAL n 
1 189 SER n 
1 190 GLU n 
1 191 LEU n 
1 192 ALA n 
1 193 ALA n 
1 194 GLU n 
1 195 ASP n 
1 196 THR n 
1 197 ILE n 
1 198 VAL n 
1 199 ALA n 
1 200 MET n 
1 201 GLU n 
1 202 GLY n 
1 203 ALA n 
1 204 LYS n 
1 205 GLU n 
1 206 GLY n 
1 207 SER n 
1 208 ASP n 
1 209 GLY n 
1 210 THR n 
1 211 ARG n 
1 212 ASN n 
1 213 ASP n 
1 214 LEU n 
1 215 GLU n 
1 216 LYS n 
1 217 GLY n 
1 218 SER n 
1 219 THR n 
1 220 VAL n 
1 221 VAL n 
1 222 GLN n 
1 223 GLN n 
1 224 LYS n 
1 225 SER n 
1 226 TYR n 
1 227 VAL n 
1 228 GLU n 
1 229 ARG n 
1 230 ALA n 
1 231 SER n 
1 232 ALA n 
1 233 LEU n 
1 234 ALA n 
1 235 LEU n 
1 236 GLY n 
1 237 ASN n 
1 238 ASN n 
1 239 LEU n 
1 240 SER n 
1 241 ASP n 
1 242 ILE n 
1 243 VAL n 
1 244 PHE n 
1 245 THR n 
1 246 ASN n 
1 247 CYS n 
1 248 LYS n 
1 249 VAL n 
1 250 VAL n 
1 251 GLY n 
1 252 ARG n 
1 253 GLN n 
1 254 ASP n 
1 255 THR n 
1 256 LEU n 
1 257 TYR n 
1 258 GLY n 
1 259 GLY n 
1 260 LYS n 
1 261 MET n 
1 262 THR n 
1 263 TYR n 
1 264 ALA n 
1 265 GLU n 
1 266 PHE n 
1 267 ASN n 
1 268 ASN n 
1 269 CYS n 
1 270 GLU n 
1 271 ILE n 
1 272 TYR n 
1 273 GLY n 
1 274 ALA n 
1 275 VAL n 
1 276 ASP n 
1 277 TYR n 
1 278 ILE n 
1 279 PHE n 
1 280 GLY n 
1 281 GLY n 
1 282 MET n 
1 283 THR n 
1 284 ALA n 
1 285 ILE n 
1 286 PHE n 
1 287 TYR n 
1 288 GLN n 
1 289 CYS n 
1 290 GLU n 
1 291 LEU n 
1 292 LYS n 
1 293 PHE n 
1 294 ASN n 
1 295 THR n 
1 296 THR n 
1 297 ASP n 
1 298 ASN n 
1 299 LYS n 
1 300 ASN n 
1 301 ASP n 
1 302 VAL n 
1 303 GLY n 
1 304 TYR n 
1 305 ILE n 
1 306 THR n 
1 307 ALA n 
1 308 ALA n 
1 309 GLN n 
1 310 GLN n 
1 311 SER n 
1 312 SER n 
1 313 GLY n 
1 314 ARG n 
1 315 GLY n 
1 316 TYR n 
1 317 LEU n 
1 318 MET n 
1 319 TYR n 
1 320 GLU n 
1 321 CYS n 
1 322 HIS n 
1 323 ILE n 
1 324 THR n 
1 325 SER n 
1 326 VAL n 
1 327 GLU n 
1 328 ALA n 
1 329 GLY n 
1 330 THR n 
1 331 ASP n 
1 332 VAL n 
1 333 ASP n 
1 334 SER n 
1 335 LYS n 
1 336 TYR n 
1 337 TYR n 
1 338 SER n 
1 339 TYR n 
1 340 THR n 
1 341 THR n 
1 342 SER n 
1 343 LYS n 
1 344 PRO n 
1 345 GLY n 
1 346 TYR n 
1 347 PHE n 
1 348 GLY n 
1 349 ARG n 
1 350 PRO n 
1 351 TRP n 
1 352 GLN n 
1 353 ALA n 
1 354 ASN n 
1 355 THR n 
1 356 SER n 
1 357 GLU n 
1 358 VAL n 
1 359 VAL n 
1 360 PHE n 
1 361 TYR n 
1 362 ASN n 
1 363 THR n 
1 364 THR n 
1 365 ILE n 
1 366 ASP n 
1 367 GLU n 
1 368 CYS n 
1 369 ASP n 
1 370 SER n 
1 371 THR n 
1 372 LEU n 
1 373 ALA n 
1 374 SER n 
1 375 THR n 
1 376 TYR n 
1 377 GLY n 
1 378 SER n 
1 379 SER n 
1 380 SER n 
1 381 LEU n 
1 382 ILE n 
1 383 GLN n 
1 384 PRO n 
1 385 ALA n 
1 386 GLY n 
1 387 TRP n 
1 388 LEU n 
1 389 ASN n 
1 390 SER n 
1 391 LEU n 
1 392 GLY n 
1 393 GLY n 
1 394 GLU n 
1 395 ALA n 
1 396 GLN n 
1 397 MET n 
1 398 TYR n 
1 399 GLU n 
1 400 TYR n 
1 401 GLY n 
1 402 THR n 
1 403 THR n 
1 404 GLU n 
1 405 SER n 
1 406 SER n 
1 407 GLY n 
1 408 VAL n 
1 409 ASP n 
1 410 ASN n 
1 411 SER n 
1 412 SER n 
1 413 ALA n 
1 414 ARG n 
1 415 ILE n 
1 416 ALA n 
1 417 SER n 
1 418 TRP n 
1 419 THR n 
1 420 THR n 
1 421 TRP n 
1 422 THR n 
1 423 THR n 
1 424 SER n 
1 425 ASP n 
1 426 SER n 
1 427 VAL n 
1 428 LEU n 
1 429 THR n 
1 430 THR n 
1 431 PRO n 
1 432 TYR n 
1 433 LEU n 
1 434 ALA n 
1 435 ASP n 
1 436 GLY n 
1 437 THR n 
1 438 LYS n 
1 439 ILE n 
1 440 THR n 
1 441 LEU n 
1 442 ASP n 
1 443 ALA n 
1 444 PHE n 
1 445 ARG n 
1 446 LYS n 
1 447 ASN n 
1 448 LYS n 
1 449 SER n 
1 450 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   450 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SAMN02745229_04032 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Butyrivibrio fibrisolvens DSM 3071' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1121131 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION' ?                 'Mg 2'           24.305  
NA  non-polymer         . 'SODIUM ION'    ?                 'Na 1'           22.990  
NH4 non-polymer         . 'AMMONIUM ION'  ?                 'H4 N 1'         18.038  
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -22 ?   ?   ?   A . n 
A 1 2   GLY 2   -21 ?   ?   ?   A . n 
A 1 3   SER 3   -20 ?   ?   ?   A . n 
A 1 4   SER 4   -19 ?   ?   ?   A . n 
A 1 5   HIS 5   -18 ?   ?   ?   A . n 
A 1 6   HIS 6   -17 ?   ?   ?   A . n 
A 1 7   HIS 7   -16 ?   ?   ?   A . n 
A 1 8   HIS 8   -15 ?   ?   ?   A . n 
A 1 9   HIS 9   -14 ?   ?   ?   A . n 
A 1 10  HIS 10  -13 ?   ?   ?   A . n 
A 1 11  SER 11  -12 ?   ?   ?   A . n 
A 1 12  SER 12  -11 ?   ?   ?   A . n 
A 1 13  GLY 13  -10 ?   ?   ?   A . n 
A 1 14  LEU 14  -9  ?   ?   ?   A . n 
A 1 15  VAL 15  -8  ?   ?   ?   A . n 
A 1 16  PRO 16  -7  ?   ?   ?   A . n 
A 1 17  ARG 17  -6  ?   ?   ?   A . n 
A 1 18  GLY 18  -5  ?   ?   ?   A . n 
A 1 19  SER 19  -4  ?   ?   ?   A . n 
A 1 20  HIS 20  -3  ?   ?   ?   A . n 
A 1 21  MET 21  -2  ?   ?   ?   A . n 
A 1 22  LEU 22  -1  ?   ?   ?   A . n 
A 1 23  GLU 23  0   ?   ?   ?   A . n 
A 1 24  MET 24  1   ?   ?   ?   A . n 
A 1 25  LYS 25  2   ?   ?   ?   A . n 
A 1 26  LYS 26  3   ?   ?   ?   A . n 
A 1 27  ALA 27  4   ?   ?   ?   A . n 
A 1 28  SER 28  5   ?   ?   ?   A . n 
A 1 29  GLU 29  6   ?   ?   ?   A . n 
A 1 30  GLU 30  7   ?   ?   ?   A . n 
A 1 31  SER 31  8   ?   ?   ?   A . n 
A 1 32  LYS 32  9   9   LYS LYS A . n 
A 1 33  ILE 33  10  10  ILE ILE A . n 
A 1 34  ALA 34  11  11  ALA ALA A . n 
A 1 35  TYR 35  12  12  TYR TYR A . n 
A 1 36  SER 36  13  13  SER SER A . n 
A 1 37  GLU 37  14  14  GLU GLU A . n 
A 1 38  ILE 38  15  15  ILE ILE A . n 
A 1 39  ILE 39  16  16  ILE ILE A . n 
A 1 40  THR 40  17  17  THR THR A . n 
A 1 41  VAL 41  18  18  VAL VAL A . n 
A 1 42  GLY 42  19  19  GLY GLY A . n 
A 1 43  THR 43  20  20  THR THR A . n 
A 1 44  ASP 44  21  21  ASP ASP A . n 
A 1 45  LYS 45  22  22  LYS LYS A . n 
A 1 46  ASP 46  23  23  ASP ASP A . n 
A 1 47  TYR 47  24  24  TYR TYR A . n 
A 1 48  LYS 48  25  25  LYS LYS A . n 
A 1 49  THR 49  26  26  THR THR A . n 
A 1 50  ILE 50  27  27  ILE ILE A . n 
A 1 51  SER 51  28  28  SER SER A . n 
A 1 52  ASP 52  29  29  ASP ASP A . n 
A 1 53  ALA 53  30  30  ALA ALA A . n 
A 1 54  ILE 54  31  31  ILE ILE A . n 
A 1 55  GLU 55  32  32  GLU GLU A . n 
A 1 56  ALA 56  33  33  ALA ALA A . n 
A 1 57  ILE 57  34  34  ILE ILE A . n 
A 1 58  ARG 58  35  35  ARG ARG A . n 
A 1 59  HIS 59  36  36  HIS HIS A . n 
A 1 60  MET 60  37  37  MET MET A . n 
A 1 61  GLU 61  38  38  GLU GLU A . n 
A 1 62  ARG 62  39  39  ARG ARG A . n 
A 1 63  ASP 63  40  40  ASP ASP A . n 
A 1 64  ASP 64  41  41  ASP ASP A . n 
A 1 65  SER 65  42  42  SER SER A . n 
A 1 66  GLN 66  43  43  GLN GLN A . n 
A 1 67  ARG 67  44  44  ARG ARG A . n 
A 1 68  VAL 68  45  45  VAL VAL A . n 
A 1 69  THR 69  46  46  THR THR A . n 
A 1 70  ILE 70  47  47  ILE ILE A . n 
A 1 71  LYS 71  48  48  LYS LYS A . n 
A 1 72  ILE 72  49  49  ILE ILE A . n 
A 1 73  ASP 73  50  50  ASP ASP A . n 
A 1 74  PRO 74  51  51  PRO PRO A . n 
A 1 75  GLY 75  52  52  GLY GLY A . n 
A 1 76  ASN 76  53  53  ASN ASN A . n 
A 1 77  TYR 77  54  54  TYR TYR A . n 
A 1 78  GLN 78  55  55  GLN GLN A . n 
A 1 79  GLU 79  56  56  GLU GLU A . n 
A 1 80  MET 80  57  57  MET MET A . n 
A 1 81  LEU 81  58  58  LEU LEU A . n 
A 1 82  ILE 82  59  59  ILE ILE A . n 
A 1 83  VAL 83  60  60  VAL VAL A . n 
A 1 84  ASP 84  61  61  ASP ASP A . n 
A 1 85  VAL 85  62  62  VAL VAL A . n 
A 1 86  ASP 86  63  63  ASP ASP A . n 
A 1 87  ASN 87  64  64  ASN ASN A . n 
A 1 88  VAL 88  65  65  VAL VAL A . n 
A 1 89  SER 89  66  66  SER SER A . n 
A 1 90  LEU 90  67  67  LEU LEU A . n 
A 1 91  VAL 91  68  68  VAL VAL A . n 
A 1 92  ASN 92  69  69  ASN ASN A . n 
A 1 93  ALA 93  70  70  ALA ALA A . n 
A 1 94  ALA 94  71  71  ALA ALA A . n 
A 1 95  GLY 95  72  72  GLY GLY A . n 
A 1 96  ASP 96  73  73  ASP ASP A . n 
A 1 97  ASP 97  74  74  ASP ASP A . n 
A 1 98  ALA 98  75  75  ALA ALA A . n 
A 1 99  SER 99  76  76  SER SER A . n 
A 1 100 ILE 100 77  77  ILE ILE A . n 
A 1 101 GLU 101 78  78  GLU GLU A . n 
A 1 102 LEU 102 79  79  LEU LEU A . n 
A 1 103 ALA 103 80  80  ALA ALA A . n 
A 1 104 ASP 104 81  81  ASP ASP A . n 
A 1 105 SER 105 82  82  SER SER A . n 
A 1 106 GLY 106 83  83  GLY GLY A . n 
A 1 107 VAL 107 84  84  VAL VAL A . n 
A 1 108 SER 108 85  85  SER SER A . n 
A 1 109 VAL 109 86  86  VAL VAL A . n 
A 1 110 SER 110 87  87  SER SER A . n 
A 1 111 ASP 111 88  88  ASP ASP A . n 
A 1 112 LYS 112 89  89  LYS LYS A . n 
A 1 113 ALA 113 90  90  ALA ALA A . n 
A 1 114 VAL 114 91  91  VAL VAL A . n 
A 1 115 ARG 115 92  92  ARG ARG A . n 
A 1 116 ILE 116 93  93  ILE ILE A . n 
A 1 117 THR 117 94  94  THR THR A . n 
A 1 118 SER 118 95  95  SER SER A . n 
A 1 119 TYR 119 96  96  TYR TYR A . n 
A 1 120 TYR 120 97  97  TYR TYR A . n 
A 1 121 GLY 121 98  98  GLY GLY A . n 
A 1 122 HIS 122 99  99  HIS HIS A . n 
A 1 123 GLY 123 100 100 GLY GLY A . n 
A 1 124 TYR 124 101 101 TYR TYR A . n 
A 1 125 THR 125 102 102 THR THR A . n 
A 1 126 TYR 126 103 103 TYR TYR A . n 
A 1 127 TYR 127 104 104 TYR TYR A . n 
A 1 128 SER 128 105 105 SER SER A . n 
A 1 129 MET 129 106 106 MET MET A . n 
A 1 130 GLY 130 107 107 GLY GLY A . n 
A 1 131 GLU 131 108 108 GLU GLU A . n 
A 1 132 ASP 132 109 109 ASP ASP A . n 
A 1 133 TYR 133 110 110 TYR TYR A . n 
A 1 134 ARG 134 111 111 ARG ARG A . n 
A 1 135 TYR 135 112 112 TYR TYR A . n 
A 1 136 ASP 136 113 113 ASP ASP A . n 
A 1 137 GLU 137 114 114 GLU GLU A . n 
A 1 138 GLU 138 115 115 GLU GLU A . n 
A 1 139 VAL 139 116 116 VAL VAL A . n 
A 1 140 LEU 140 117 117 LEU LEU A . n 
A 1 141 LYS 141 118 118 LYS LYS A . n 
A 1 142 VAL 142 119 119 VAL VAL A . n 
A 1 143 ASN 143 120 120 ASN ASN A . n 
A 1 144 GLN 144 121 121 GLN GLN A . n 
A 1 145 GLU 145 122 122 GLU GLU A . n 
A 1 146 ASN 146 123 123 ASN ASN A . n 
A 1 147 GLY 147 124 124 GLY GLY A . n 
A 1 148 TYR 148 125 125 TYR TYR A . n 
A 1 149 PRO 149 126 126 PRO PRO A . n 
A 1 150 SER 150 127 127 SER SER A . n 
A 1 151 VAL 151 128 128 VAL VAL A . n 
A 1 152 THR 152 129 129 THR THR A . n 
A 1 153 ASN 153 130 130 ASN ASN A . n 
A 1 154 PRO 154 131 131 PRO PRO A . n 
A 1 155 GLY 155 132 132 GLY GLY A . n 
A 1 156 SER 156 133 133 SER SER A . n 
A 1 157 GLY 157 134 134 GLY GLY A . n 
A 1 158 THR 158 135 135 THR THR A . n 
A 1 159 ALA 159 136 136 ALA ALA A . n 
A 1 160 THR 160 137 137 THR THR A . n 
A 1 161 MET 161 138 138 MET MET A . n 
A 1 162 TRP 162 139 139 TRP TRP A . n 
A 1 163 ASN 163 140 140 ASN ASN A . n 
A 1 164 ALA 164 141 141 ALA ALA A . n 
A 1 165 THR 165 142 142 THR THR A . n 
A 1 166 VAL 166 143 143 VAL VAL A . n 
A 1 167 TYR 167 144 144 TYR TYR A . n 
A 1 168 VAL 168 145 145 VAL VAL A . n 
A 1 169 ASN 169 146 146 ASN ASN A . n 
A 1 170 ALA 170 147 147 ALA ALA A . n 
A 1 171 ASP 171 148 148 ASP ASP A . n 
A 1 172 GLY 172 149 149 GLY GLY A . n 
A 1 173 PHE 173 150 150 PHE PHE A . n 
A 1 174 GLU 174 151 151 GLU GLU A . n 
A 1 175 ALA 175 152 152 ALA ALA A . n 
A 1 176 GLU 176 153 153 GLU GLU A . n 
A 1 177 GLY 177 154 154 GLY GLY A . n 
A 1 178 ILE 178 155 155 ILE ILE A . n 
A 1 179 ILE 179 156 156 ILE ILE A . n 
A 1 180 PHE 180 157 157 PHE PHE A . n 
A 1 181 GLU 181 158 158 GLU GLU A . n 
A 1 182 ASN 182 159 159 ASN ASN A . n 
A 1 183 SER 183 160 160 SER SER A . n 
A 1 184 PHE 184 161 161 PHE PHE A . n 
A 1 185 ASN 185 162 162 ASN ASN A . n 
A 1 186 GLN 186 163 163 GLN GLN A . n 
A 1 187 TYR 187 164 164 TYR TYR A . n 
A 1 188 VAL 188 165 165 VAL VAL A . n 
A 1 189 SER 189 166 166 SER SER A . n 
A 1 190 GLU 190 167 167 GLU GLU A . n 
A 1 191 LEU 191 168 168 LEU LEU A . n 
A 1 192 ALA 192 169 169 ALA ALA A . n 
A 1 193 ALA 193 170 170 ALA ALA A . n 
A 1 194 GLU 194 171 171 GLU GLU A . n 
A 1 195 ASP 195 172 172 ASP ASP A . n 
A 1 196 THR 196 173 173 THR THR A . n 
A 1 197 ILE 197 174 174 ILE ILE A . n 
A 1 198 VAL 198 175 175 VAL VAL A . n 
A 1 199 ALA 199 176 176 ALA ALA A . n 
A 1 200 MET 200 177 177 MET MET A . n 
A 1 201 GLU 201 178 178 GLU GLU A . n 
A 1 202 GLY 202 179 179 GLY GLY A . n 
A 1 203 ALA 203 180 180 ALA ALA A . n 
A 1 204 LYS 204 181 181 LYS LYS A . n 
A 1 205 GLU 205 182 182 GLU GLU A . n 
A 1 206 GLY 206 183 183 GLY GLY A . n 
A 1 207 SER 207 184 184 SER SER A . n 
A 1 208 ASP 208 185 185 ASP ASP A . n 
A 1 209 GLY 209 186 186 GLY GLY A . n 
A 1 210 THR 210 187 187 THR THR A . n 
A 1 211 ARG 211 188 188 ARG ARG A . n 
A 1 212 ASN 212 189 189 ASN ASN A . n 
A 1 213 ASP 213 190 190 ASP ASP A . n 
A 1 214 LEU 214 191 191 LEU LEU A . n 
A 1 215 GLU 215 192 192 GLU GLU A . n 
A 1 216 LYS 216 193 193 LYS LYS A . n 
A 1 217 GLY 217 194 194 GLY GLY A . n 
A 1 218 SER 218 195 195 SER SER A . n 
A 1 219 THR 219 196 196 THR THR A . n 
A 1 220 VAL 220 197 197 VAL VAL A . n 
A 1 221 VAL 221 198 198 VAL VAL A . n 
A 1 222 GLN 222 199 199 GLN GLN A . n 
A 1 223 GLN 223 200 200 GLN GLN A . n 
A 1 224 LYS 224 201 201 LYS LYS A . n 
A 1 225 SER 225 202 202 SER SER A . n 
A 1 226 TYR 226 203 203 TYR TYR A . n 
A 1 227 VAL 227 204 204 VAL VAL A . n 
A 1 228 GLU 228 205 205 GLU GLU A . n 
A 1 229 ARG 229 206 206 ARG ARG A . n 
A 1 230 ALA 230 207 207 ALA ALA A . n 
A 1 231 SER 231 208 208 SER SER A . n 
A 1 232 ALA 232 209 209 ALA ALA A . n 
A 1 233 LEU 233 210 210 LEU LEU A . n 
A 1 234 ALA 234 211 211 ALA ALA A . n 
A 1 235 LEU 235 212 212 LEU LEU A . n 
A 1 236 GLY 236 213 213 GLY GLY A . n 
A 1 237 ASN 237 214 214 ASN ASN A . n 
A 1 238 ASN 238 215 215 ASN ASN A . n 
A 1 239 LEU 239 216 216 LEU LEU A . n 
A 1 240 SER 240 217 217 SER SER A . n 
A 1 241 ASP 241 218 218 ASP ASP A . n 
A 1 242 ILE 242 219 219 ILE ILE A . n 
A 1 243 VAL 243 220 220 VAL VAL A . n 
A 1 244 PHE 244 221 221 PHE PHE A . n 
A 1 245 THR 245 222 222 THR THR A . n 
A 1 246 ASN 246 223 223 ASN ASN A . n 
A 1 247 CYS 247 224 224 CYS CYS A . n 
A 1 248 LYS 248 225 225 LYS LYS A . n 
A 1 249 VAL 249 226 226 VAL VAL A . n 
A 1 250 VAL 250 227 227 VAL VAL A . n 
A 1 251 GLY 251 228 228 GLY GLY A . n 
A 1 252 ARG 252 229 229 ARG ARG A . n 
A 1 253 GLN 253 230 230 GLN GLN A . n 
A 1 254 ASP 254 231 231 ASP ASP A . n 
A 1 255 THR 255 232 232 THR THR A . n 
A 1 256 LEU 256 233 233 LEU LEU A . n 
A 1 257 TYR 257 234 234 TYR TYR A . n 
A 1 258 GLY 258 235 235 GLY GLY A . n 
A 1 259 GLY 259 236 236 GLY GLY A . n 
A 1 260 LYS 260 237 237 LYS LYS A . n 
A 1 261 MET 261 238 238 MET MET A . n 
A 1 262 THR 262 239 239 THR THR A . n 
A 1 263 TYR 263 240 240 TYR TYR A . n 
A 1 264 ALA 264 241 241 ALA ALA A . n 
A 1 265 GLU 265 242 242 GLU GLU A . n 
A 1 266 PHE 266 243 243 PHE PHE A . n 
A 1 267 ASN 267 244 244 ASN ASN A . n 
A 1 268 ASN 268 245 245 ASN ASN A . n 
A 1 269 CYS 269 246 246 CYS CYS A . n 
A 1 270 GLU 270 247 247 GLU GLU A . n 
A 1 271 ILE 271 248 248 ILE ILE A . n 
A 1 272 TYR 272 249 249 TYR TYR A . n 
A 1 273 GLY 273 250 250 GLY GLY A . n 
A 1 274 ALA 274 251 251 ALA ALA A . n 
A 1 275 VAL 275 252 252 VAL VAL A . n 
A 1 276 ASP 276 253 253 ASP ASP A . n 
A 1 277 TYR 277 254 254 TYR TYR A . n 
A 1 278 ILE 278 255 255 ILE ILE A . n 
A 1 279 PHE 279 256 256 PHE PHE A . n 
A 1 280 GLY 280 257 257 GLY GLY A . n 
A 1 281 GLY 281 258 258 GLY GLY A . n 
A 1 282 MET 282 259 259 MET MET A . n 
A 1 283 THR 283 260 260 THR THR A . n 
A 1 284 ALA 284 261 261 ALA ALA A . n 
A 1 285 ILE 285 262 262 ILE ILE A . n 
A 1 286 PHE 286 263 263 PHE PHE A . n 
A 1 287 TYR 287 264 264 TYR TYR A . n 
A 1 288 GLN 288 265 265 GLN GLN A . n 
A 1 289 CYS 289 266 266 CYS CYS A . n 
A 1 290 GLU 290 267 267 GLU GLU A . n 
A 1 291 LEU 291 268 268 LEU LEU A . n 
A 1 292 LYS 292 269 269 LYS LYS A . n 
A 1 293 PHE 293 270 270 PHE PHE A . n 
A 1 294 ASN 294 271 271 ASN ASN A . n 
A 1 295 THR 295 272 272 THR THR A . n 
A 1 296 THR 296 273 273 THR THR A . n 
A 1 297 ASP 297 274 274 ASP ASP A . n 
A 1 298 ASN 298 275 275 ASN ASN A . n 
A 1 299 LYS 299 276 276 LYS LYS A . n 
A 1 300 ASN 300 277 277 ASN ASN A . n 
A 1 301 ASP 301 278 278 ASP ASP A . n 
A 1 302 VAL 302 279 279 VAL VAL A . n 
A 1 303 GLY 303 280 280 GLY GLY A . n 
A 1 304 TYR 304 281 281 TYR TYR A . n 
A 1 305 ILE 305 282 282 ILE ILE A . n 
A 1 306 THR 306 283 283 THR THR A . n 
A 1 307 ALA 307 284 284 ALA ALA A . n 
A 1 308 ALA 308 285 285 ALA ALA A . n 
A 1 309 GLN 309 286 286 GLN GLN A . n 
A 1 310 GLN 310 287 287 GLN GLN A . n 
A 1 311 SER 311 288 288 SER SER A . n 
A 1 312 SER 312 289 289 SER SER A . n 
A 1 313 GLY 313 290 290 GLY GLY A . n 
A 1 314 ARG 314 291 291 ARG ARG A . n 
A 1 315 GLY 315 292 292 GLY GLY A . n 
A 1 316 TYR 316 293 293 TYR TYR A . n 
A 1 317 LEU 317 294 294 LEU LEU A . n 
A 1 318 MET 318 295 295 MET MET A . n 
A 1 319 TYR 319 296 296 TYR TYR A . n 
A 1 320 GLU 320 297 297 GLU GLU A . n 
A 1 321 CYS 321 298 298 CYS CYS A . n 
A 1 322 HIS 322 299 299 HIS HIS A . n 
A 1 323 ILE 323 300 300 ILE ILE A . n 
A 1 324 THR 324 301 301 THR THR A . n 
A 1 325 SER 325 302 302 SER SER A . n 
A 1 326 VAL 326 303 303 VAL VAL A . n 
A 1 327 GLU 327 304 304 GLU GLU A . n 
A 1 328 ALA 328 305 305 ALA ALA A . n 
A 1 329 GLY 329 306 306 GLY GLY A . n 
A 1 330 THR 330 307 307 THR THR A . n 
A 1 331 ASP 331 308 308 ASP ASP A . n 
A 1 332 VAL 332 309 309 VAL VAL A . n 
A 1 333 ASP 333 310 310 ASP ASP A . n 
A 1 334 SER 334 311 311 SER SER A . n 
A 1 335 LYS 335 312 312 LYS LYS A . n 
A 1 336 TYR 336 313 313 TYR TYR A . n 
A 1 337 TYR 337 314 314 TYR TYR A . n 
A 1 338 SER 338 315 315 SER SER A . n 
A 1 339 TYR 339 316 316 TYR TYR A . n 
A 1 340 THR 340 317 317 THR THR A . n 
A 1 341 THR 341 318 318 THR THR A . n 
A 1 342 SER 342 319 319 SER SER A . n 
A 1 343 LYS 343 320 320 LYS LYS A . n 
A 1 344 PRO 344 321 321 PRO PRO A . n 
A 1 345 GLY 345 322 322 GLY GLY A . n 
A 1 346 TYR 346 323 323 TYR TYR A . n 
A 1 347 PHE 347 324 324 PHE PHE A . n 
A 1 348 GLY 348 325 325 GLY GLY A . n 
A 1 349 ARG 349 326 326 ARG ARG A . n 
A 1 350 PRO 350 327 327 PRO PRO A . n 
A 1 351 TRP 351 328 328 TRP TRP A . n 
A 1 352 GLN 352 329 329 GLN GLN A . n 
A 1 353 ALA 353 330 330 ALA ALA A . n 
A 1 354 ASN 354 331 331 ASN ASN A . n 
A 1 355 THR 355 332 332 THR THR A . n 
A 1 356 SER 356 333 333 SER SER A . n 
A 1 357 GLU 357 334 334 GLU GLU A . n 
A 1 358 VAL 358 335 335 VAL VAL A . n 
A 1 359 VAL 359 336 336 VAL VAL A . n 
A 1 360 PHE 360 337 337 PHE PHE A . n 
A 1 361 TYR 361 338 338 TYR TYR A . n 
A 1 362 ASN 362 339 339 ASN ASN A . n 
A 1 363 THR 363 340 340 THR THR A . n 
A 1 364 THR 364 341 341 THR THR A . n 
A 1 365 ILE 365 342 342 ILE ILE A . n 
A 1 366 ASP 366 343 343 ASP ASP A . n 
A 1 367 GLU 367 344 344 GLU GLU A . n 
A 1 368 CYS 368 345 345 CYS CYS A . n 
A 1 369 ASP 369 346 346 ASP ASP A . n 
A 1 370 SER 370 347 347 SER SER A . n 
A 1 371 THR 371 348 348 THR THR A . n 
A 1 372 LEU 372 349 349 LEU LEU A . n 
A 1 373 ALA 373 350 350 ALA ALA A . n 
A 1 374 SER 374 351 351 SER SER A . n 
A 1 375 THR 375 352 352 THR THR A . n 
A 1 376 TYR 376 353 353 TYR TYR A . n 
A 1 377 GLY 377 354 354 GLY GLY A . n 
A 1 378 SER 378 355 355 SER SER A . n 
A 1 379 SER 379 356 356 SER SER A . n 
A 1 380 SER 380 357 357 SER SER A . n 
A 1 381 LEU 381 358 358 LEU LEU A . n 
A 1 382 ILE 382 359 359 ILE ILE A . n 
A 1 383 GLN 383 360 360 GLN GLN A . n 
A 1 384 PRO 384 361 361 PRO PRO A . n 
A 1 385 ALA 385 362 362 ALA ALA A . n 
A 1 386 GLY 386 363 363 GLY GLY A . n 
A 1 387 TRP 387 364 364 TRP TRP A . n 
A 1 388 LEU 388 365 365 LEU LEU A . n 
A 1 389 ASN 389 366 366 ASN ASN A . n 
A 1 390 SER 390 367 367 SER SER A . n 
A 1 391 LEU 391 368 368 LEU LEU A . n 
A 1 392 GLY 392 369 369 GLY GLY A . n 
A 1 393 GLY 393 370 370 GLY GLY A . n 
A 1 394 GLU 394 371 371 GLU GLU A . n 
A 1 395 ALA 395 372 372 ALA ALA A . n 
A 1 396 GLN 396 373 373 GLN GLN A . n 
A 1 397 MET 397 374 374 MET MET A . n 
A 1 398 TYR 398 375 375 TYR TYR A . n 
A 1 399 GLU 399 376 376 GLU GLU A . n 
A 1 400 TYR 400 377 377 TYR TYR A . n 
A 1 401 GLY 401 378 378 GLY GLY A . n 
A 1 402 THR 402 379 379 THR THR A . n 
A 1 403 THR 403 380 380 THR THR A . n 
A 1 404 GLU 404 381 381 GLU GLU A . n 
A 1 405 SER 405 382 382 SER SER A . n 
A 1 406 SER 406 383 383 SER SER A . n 
A 1 407 GLY 407 384 384 GLY GLY A . n 
A 1 408 VAL 408 385 385 VAL VAL A . n 
A 1 409 ASP 409 386 386 ASP ASP A . n 
A 1 410 ASN 410 387 387 ASN ASN A . n 
A 1 411 SER 411 388 388 SER SER A . n 
A 1 412 SER 412 389 389 SER SER A . n 
A 1 413 ALA 413 390 390 ALA ALA A . n 
A 1 414 ARG 414 391 391 ARG ARG A . n 
A 1 415 ILE 415 392 392 ILE ILE A . n 
A 1 416 ALA 416 393 393 ALA ALA A . n 
A 1 417 SER 417 394 394 SER SER A . n 
A 1 418 TRP 418 395 395 TRP TRP A . n 
A 1 419 THR 419 396 396 THR THR A . n 
A 1 420 THR 420 397 397 THR THR A . n 
A 1 421 TRP 421 398 398 TRP TRP A . n 
A 1 422 THR 422 399 399 THR THR A . n 
A 1 423 THR 423 400 400 THR THR A . n 
A 1 424 SER 424 401 401 SER SER A . n 
A 1 425 ASP 425 402 402 ASP ASP A . n 
A 1 426 SER 426 403 403 SER SER A . n 
A 1 427 VAL 427 404 404 VAL VAL A . n 
A 1 428 LEU 428 405 405 LEU LEU A . n 
A 1 429 THR 429 406 406 THR THR A . n 
A 1 430 THR 430 407 407 THR THR A . n 
A 1 431 PRO 431 408 408 PRO PRO A . n 
A 1 432 TYR 432 409 409 TYR TYR A . n 
A 1 433 LEU 433 410 410 LEU LEU A . n 
A 1 434 ALA 434 411 411 ALA ALA A . n 
A 1 435 ASP 435 412 412 ASP ASP A . n 
A 1 436 GLY 436 413 413 GLY GLY A . n 
A 1 437 THR 437 414 414 THR THR A . n 
A 1 438 LYS 438 415 415 LYS LYS A . n 
A 1 439 ILE 439 416 416 ILE ILE A . n 
A 1 440 THR 440 417 417 THR THR A . n 
A 1 441 LEU 441 418 418 LEU LEU A . n 
A 1 442 ASP 442 419 419 ASP ASP A . n 
A 1 443 ALA 443 420 420 ALA ALA A . n 
A 1 444 PHE 444 421 421 PHE PHE A . n 
A 1 445 ARG 445 422 422 ARG ARG A . n 
A 1 446 LYS 446 423 423 LYS LYS A . n 
A 1 447 ASN 447 424 424 ASN ASN A . n 
A 1 448 LYS 448 425 425 LYS LYS A . n 
A 1 449 SER 449 426 426 SER SER A . n 
A 1 450 GLY 450 427 427 GLY GLY A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 MG  1   501  3   MG  MG  A . 
C 2 MG  1   502  5   MG  MG  A . 
D 2 MG  1   503  6   MG  MG  A . 
E 3 NA  1   504  1   NA  NA  A . 
F 3 NA  1   505  2   NA  NA  A . 
G 3 NA  1   506  3   NA  NA  A . 
H 4 EDO 1   507  1   EDO EDO A . 
I 4 EDO 1   508  2   EDO EDO A . 
J 4 EDO 1   509  9   EDO EDO A . 
K 4 EDO 1   510  10  EDO EDO A . 
L 4 EDO 1   511  12  EDO EDO A . 
M 4 EDO 1   512  13  EDO EDO A . 
N 4 EDO 1   513  14  EDO EDO A . 
O 4 EDO 1   514  16  EDO EDO A . 
P 4 EDO 1   515  18  EDO EDO A . 
Q 5 NH4 1   516  17  NH4 NH4 A . 
R 6 HOH 1   601  458 HOH HOH A . 
R 6 HOH 2   602  609 HOH HOH A . 
R 6 HOH 3   603  523 HOH HOH A . 
R 6 HOH 4   604  633 HOH HOH A . 
R 6 HOH 5   605  604 HOH HOH A . 
R 6 HOH 6   606  182 HOH HOH A . 
R 6 HOH 7   607  603 HOH HOH A . 
R 6 HOH 8   608  312 HOH HOH A . 
R 6 HOH 9   609  522 HOH HOH A . 
R 6 HOH 10  610  601 HOH HOH A . 
R 6 HOH 11  611  672 HOH HOH A . 
R 6 HOH 12  612  498 HOH HOH A . 
R 6 HOH 13  613  168 HOH HOH A . 
R 6 HOH 14  614  408 HOH HOH A . 
R 6 HOH 15  615  670 HOH HOH A . 
R 6 HOH 16  616  447 HOH HOH A . 
R 6 HOH 17  617  460 HOH HOH A . 
R 6 HOH 18  618  409 HOH HOH A . 
R 6 HOH 19  619  599 HOH HOH A . 
R 6 HOH 20  620  619 HOH HOH A . 
R 6 HOH 21  621  187 HOH HOH A . 
R 6 HOH 22  622  337 HOH HOH A . 
R 6 HOH 23  623  634 HOH HOH A . 
R 6 HOH 24  624  163 HOH HOH A . 
R 6 HOH 25  625  419 HOH HOH A . 
R 6 HOH 26  626  519 HOH HOH A . 
R 6 HOH 27  627  505 HOH HOH A . 
R 6 HOH 28  628  341 HOH HOH A . 
R 6 HOH 29  629  162 HOH HOH A . 
R 6 HOH 30  630  450 HOH HOH A . 
R 6 HOH 31  631  211 HOH HOH A . 
R 6 HOH 32  632  529 HOH HOH A . 
R 6 HOH 33  633  198 HOH HOH A . 
R 6 HOH 34  634  321 HOH HOH A . 
R 6 HOH 35  635  550 HOH HOH A . 
R 6 HOH 36  636  466 HOH HOH A . 
R 6 HOH 37  637  282 HOH HOH A . 
R 6 HOH 38  638  678 HOH HOH A . 
R 6 HOH 39  639  405 HOH HOH A . 
R 6 HOH 40  640  226 HOH HOH A . 
R 6 HOH 41  641  151 HOH HOH A . 
R 6 HOH 42  642  344 HOH HOH A . 
R 6 HOH 43  643  256 HOH HOH A . 
R 6 HOH 44  644  116 HOH HOH A . 
R 6 HOH 45  645  102 HOH HOH A . 
R 6 HOH 46  646  542 HOH HOH A . 
R 6 HOH 47  647  82  HOH HOH A . 
R 6 HOH 48  648  494 HOH HOH A . 
R 6 HOH 49  649  214 HOH HOH A . 
R 6 HOH 50  650  402 HOH HOH A . 
R 6 HOH 51  651  91  HOH HOH A . 
R 6 HOH 52  652  53  HOH HOH A . 
R 6 HOH 53  653  547 HOH HOH A . 
R 6 HOH 54  654  262 HOH HOH A . 
R 6 HOH 55  655  84  HOH HOH A . 
R 6 HOH 56  656  467 HOH HOH A . 
R 6 HOH 57  657  216 HOH HOH A . 
R 6 HOH 58  658  454 HOH HOH A . 
R 6 HOH 59  659  420 HOH HOH A . 
R 6 HOH 60  660  335 HOH HOH A . 
R 6 HOH 61  661  504 HOH HOH A . 
R 6 HOH 62  662  150 HOH HOH A . 
R 6 HOH 63  663  65  HOH HOH A . 
R 6 HOH 64  664  521 HOH HOH A . 
R 6 HOH 65  665  114 HOH HOH A . 
R 6 HOH 66  666  136 HOH HOH A . 
R 6 HOH 67  667  227 HOH HOH A . 
R 6 HOH 68  668  425 HOH HOH A . 
R 6 HOH 69  669  83  HOH HOH A . 
R 6 HOH 70  670  87  HOH HOH A . 
R 6 HOH 71  671  248 HOH HOH A . 
R 6 HOH 72  672  20  HOH HOH A . 
R 6 HOH 73  673  193 HOH HOH A . 
R 6 HOH 74  674  404 HOH HOH A . 
R 6 HOH 75  675  292 HOH HOH A . 
R 6 HOH 76  676  177 HOH HOH A . 
R 6 HOH 77  677  313 HOH HOH A . 
R 6 HOH 78  678  374 HOH HOH A . 
R 6 HOH 79  679  103 HOH HOH A . 
R 6 HOH 80  680  223 HOH HOH A . 
R 6 HOH 81  681  229 HOH HOH A . 
R 6 HOH 82  682  416 HOH HOH A . 
R 6 HOH 83  683  358 HOH HOH A . 
R 6 HOH 84  684  372 HOH HOH A . 
R 6 HOH 85  685  491 HOH HOH A . 
R 6 HOH 86  686  330 HOH HOH A . 
R 6 HOH 87  687  157 HOH HOH A . 
R 6 HOH 88  688  237 HOH HOH A . 
R 6 HOH 89  689  368 HOH HOH A . 
R 6 HOH 90  690  89  HOH HOH A . 
R 6 HOH 91  691  536 HOH HOH A . 
R 6 HOH 92  692  459 HOH HOH A . 
R 6 HOH 93  693  189 HOH HOH A . 
R 6 HOH 94  694  677 HOH HOH A . 
R 6 HOH 95  695  236 HOH HOH A . 
R 6 HOH 96  696  14  HOH HOH A . 
R 6 HOH 97  697  76  HOH HOH A . 
R 6 HOH 98  698  225 HOH HOH A . 
R 6 HOH 99  699  165 HOH HOH A . 
R 6 HOH 100 700  149 HOH HOH A . 
R 6 HOH 101 701  463 HOH HOH A . 
R 6 HOH 102 702  496 HOH HOH A . 
R 6 HOH 103 703  175 HOH HOH A . 
R 6 HOH 104 704  194 HOH HOH A . 
R 6 HOH 105 705  234 HOH HOH A . 
R 6 HOH 106 706  239 HOH HOH A . 
R 6 HOH 107 707  357 HOH HOH A . 
R 6 HOH 108 708  28  HOH HOH A . 
R 6 HOH 109 709  135 HOH HOH A . 
R 6 HOH 110 710  373 HOH HOH A . 
R 6 HOH 111 711  47  HOH HOH A . 
R 6 HOH 112 712  510 HOH HOH A . 
R 6 HOH 113 713  106 HOH HOH A . 
R 6 HOH 114 714  90  HOH HOH A . 
R 6 HOH 115 715  356 HOH HOH A . 
R 6 HOH 116 716  18  HOH HOH A . 
R 6 HOH 117 717  129 HOH HOH A . 
R 6 HOH 118 718  353 HOH HOH A . 
R 6 HOH 119 719  280 HOH HOH A . 
R 6 HOH 120 720  22  HOH HOH A . 
R 6 HOH 121 721  24  HOH HOH A . 
R 6 HOH 122 722  25  HOH HOH A . 
R 6 HOH 123 723  9   HOH HOH A . 
R 6 HOH 124 724  161 HOH HOH A . 
R 6 HOH 125 725  207 HOH HOH A . 
R 6 HOH 126 726  329 HOH HOH A . 
R 6 HOH 127 727  366 HOH HOH A . 
R 6 HOH 128 728  347 HOH HOH A . 
R 6 HOH 129 729  144 HOH HOH A . 
R 6 HOH 130 730  397 HOH HOH A . 
R 6 HOH 131 731  46  HOH HOH A . 
R 6 HOH 132 732  96  HOH HOH A . 
R 6 HOH 133 733  257 HOH HOH A . 
R 6 HOH 134 734  371 HOH HOH A . 
R 6 HOH 135 735  118 HOH HOH A . 
R 6 HOH 136 736  475 HOH HOH A . 
R 6 HOH 137 737  147 HOH HOH A . 
R 6 HOH 138 738  15  HOH HOH A . 
R 6 HOH 139 739  309 HOH HOH A . 
R 6 HOH 140 740  254 HOH HOH A . 
R 6 HOH 141 741  146 HOH HOH A . 
R 6 HOH 142 742  173 HOH HOH A . 
R 6 HOH 143 743  66  HOH HOH A . 
R 6 HOH 144 744  336 HOH HOH A . 
R 6 HOH 145 745  526 HOH HOH A . 
R 6 HOH 146 746  258 HOH HOH A . 
R 6 HOH 147 747  69  HOH HOH A . 
R 6 HOH 148 748  263 HOH HOH A . 
R 6 HOH 149 749  286 HOH HOH A . 
R 6 HOH 150 750  396 HOH HOH A . 
R 6 HOH 151 751  178 HOH HOH A . 
R 6 HOH 152 752  429 HOH HOH A . 
R 6 HOH 153 753  274 HOH HOH A . 
R 6 HOH 154 754  137 HOH HOH A . 
R 6 HOH 155 755  181 HOH HOH A . 
R 6 HOH 156 756  349 HOH HOH A . 
R 6 HOH 157 757  10  HOH HOH A . 
R 6 HOH 158 758  19  HOH HOH A . 
R 6 HOH 159 759  52  HOH HOH A . 
R 6 HOH 160 760  231 HOH HOH A . 
R 6 HOH 161 761  107 HOH HOH A . 
R 6 HOH 162 762  169 HOH HOH A . 
R 6 HOH 163 763  190 HOH HOH A . 
R 6 HOH 164 764  666 HOH HOH A . 
R 6 HOH 165 765  272 HOH HOH A . 
R 6 HOH 166 766  230 HOH HOH A . 
R 6 HOH 167 767  27  HOH HOH A . 
R 6 HOH 168 768  326 HOH HOH A . 
R 6 HOH 169 769  288 HOH HOH A . 
R 6 HOH 170 770  205 HOH HOH A . 
R 6 HOH 171 771  64  HOH HOH A . 
R 6 HOH 172 772  43  HOH HOH A . 
R 6 HOH 173 773  88  HOH HOH A . 
R 6 HOH 174 774  276 HOH HOH A . 
R 6 HOH 175 775  2   HOH HOH A . 
R 6 HOH 176 776  245 HOH HOH A . 
R 6 HOH 177 777  180 HOH HOH A . 
R 6 HOH 178 778  375 HOH HOH A . 
R 6 HOH 179 779  315 HOH HOH A . 
R 6 HOH 180 780  58  HOH HOH A . 
R 6 HOH 181 781  78  HOH HOH A . 
R 6 HOH 182 782  362 HOH HOH A . 
R 6 HOH 183 783  99  HOH HOH A . 
R 6 HOH 184 784  26  HOH HOH A . 
R 6 HOH 185 785  411 HOH HOH A . 
R 6 HOH 186 786  469 HOH HOH A . 
R 6 HOH 187 787  391 HOH HOH A . 
R 6 HOH 188 788  145 HOH HOH A . 
R 6 HOH 189 789  33  HOH HOH A . 
R 6 HOH 190 790  92  HOH HOH A . 
R 6 HOH 191 791  13  HOH HOH A . 
R 6 HOH 192 792  195 HOH HOH A . 
R 6 HOH 193 793  131 HOH HOH A . 
R 6 HOH 194 794  333 HOH HOH A . 
R 6 HOH 195 795  122 HOH HOH A . 
R 6 HOH 196 796  61  HOH HOH A . 
R 6 HOH 197 797  68  HOH HOH A . 
R 6 HOH 198 798  268 HOH HOH A . 
R 6 HOH 199 799  363 HOH HOH A . 
R 6 HOH 200 800  104 HOH HOH A . 
R 6 HOH 201 801  172 HOH HOH A . 
R 6 HOH 202 802  544 HOH HOH A . 
R 6 HOH 203 803  390 HOH HOH A . 
R 6 HOH 204 804  306 HOH HOH A . 
R 6 HOH 205 805  154 HOH HOH A . 
R 6 HOH 206 806  253 HOH HOH A . 
R 6 HOH 207 807  11  HOH HOH A . 
R 6 HOH 208 808  432 HOH HOH A . 
R 6 HOH 209 809  105 HOH HOH A . 
R 6 HOH 210 810  319 HOH HOH A . 
R 6 HOH 211 811  361 HOH HOH A . 
R 6 HOH 212 812  206 HOH HOH A . 
R 6 HOH 213 813  138 HOH HOH A . 
R 6 HOH 214 814  30  HOH HOH A . 
R 6 HOH 215 815  345 HOH HOH A . 
R 6 HOH 216 816  298 HOH HOH A . 
R 6 HOH 217 817  134 HOH HOH A . 
R 6 HOH 218 818  406 HOH HOH A . 
R 6 HOH 219 819  98  HOH HOH A . 
R 6 HOH 220 820  316 HOH HOH A . 
R 6 HOH 221 821  247 HOH HOH A . 
R 6 HOH 222 822  451 HOH HOH A . 
R 6 HOH 223 823  515 HOH HOH A . 
R 6 HOH 224 824  31  HOH HOH A . 
R 6 HOH 225 825  133 HOH HOH A . 
R 6 HOH 226 826  310 HOH HOH A . 
R 6 HOH 227 827  203 HOH HOH A . 
R 6 HOH 228 828  338 HOH HOH A . 
R 6 HOH 229 829  461 HOH HOH A . 
R 6 HOH 230 830  305 HOH HOH A . 
R 6 HOH 231 831  440 HOH HOH A . 
R 6 HOH 232 832  119 HOH HOH A . 
R 6 HOH 233 833  364 HOH HOH A . 
R 6 HOH 234 834  222 HOH HOH A . 
R 6 HOH 235 835  54  HOH HOH A . 
R 6 HOH 236 836  80  HOH HOH A . 
R 6 HOH 237 837  311 HOH HOH A . 
R 6 HOH 238 838  233 HOH HOH A . 
R 6 HOH 239 839  40  HOH HOH A . 
R 6 HOH 240 840  39  HOH HOH A . 
R 6 HOH 241 841  59  HOH HOH A . 
R 6 HOH 242 842  281 HOH HOH A . 
R 6 HOH 243 843  186 HOH HOH A . 
R 6 HOH 244 844  51  HOH HOH A . 
R 6 HOH 245 845  16  HOH HOH A . 
R 6 HOH 246 846  385 HOH HOH A . 
R 6 HOH 247 847  36  HOH HOH A . 
R 6 HOH 248 848  299 HOH HOH A . 
R 6 HOH 249 849  307 HOH HOH A . 
R 6 HOH 250 850  395 HOH HOH A . 
R 6 HOH 251 851  3   HOH HOH A . 
R 6 HOH 252 852  235 HOH HOH A . 
R 6 HOH 253 853  113 HOH HOH A . 
R 6 HOH 254 854  261 HOH HOH A . 
R 6 HOH 255 855  42  HOH HOH A . 
R 6 HOH 256 856  525 HOH HOH A . 
R 6 HOH 257 857  191 HOH HOH A . 
R 6 HOH 258 858  127 HOH HOH A . 
R 6 HOH 259 859  448 HOH HOH A . 
R 6 HOH 260 860  325 HOH HOH A . 
R 6 HOH 261 861  5   HOH HOH A . 
R 6 HOH 262 862  164 HOH HOH A . 
R 6 HOH 263 863  141 HOH HOH A . 
R 6 HOH 264 864  86  HOH HOH A . 
R 6 HOH 265 865  267 HOH HOH A . 
R 6 HOH 266 866  238 HOH HOH A . 
R 6 HOH 267 867  314 HOH HOH A . 
R 6 HOH 268 868  355 HOH HOH A . 
R 6 HOH 269 869  293 HOH HOH A . 
R 6 HOH 270 870  543 HOH HOH A . 
R 6 HOH 271 871  279 HOH HOH A . 
R 6 HOH 272 872  442 HOH HOH A . 
R 6 HOH 273 873  8   HOH HOH A . 
R 6 HOH 274 874  387 HOH HOH A . 
R 6 HOH 275 875  538 HOH HOH A . 
R 6 HOH 276 876  17  HOH HOH A . 
R 6 HOH 277 877  208 HOH HOH A . 
R 6 HOH 278 878  495 HOH HOH A . 
R 6 HOH 279 879  611 HOH HOH A . 
R 6 HOH 280 880  541 HOH HOH A . 
R 6 HOH 281 881  37  HOH HOH A . 
R 6 HOH 282 882  201 HOH HOH A . 
R 6 HOH 283 883  399 HOH HOH A . 
R 6 HOH 284 884  424 HOH HOH A . 
R 6 HOH 285 885  179 HOH HOH A . 
R 6 HOH 286 886  156 HOH HOH A . 
R 6 HOH 287 887  462 HOH HOH A . 
R 6 HOH 288 888  21  HOH HOH A . 
R 6 HOH 289 889  403 HOH HOH A . 
R 6 HOH 290 890  340 HOH HOH A . 
R 6 HOH 291 891  535 HOH HOH A . 
R 6 HOH 292 892  185 HOH HOH A . 
R 6 HOH 293 893  407 HOH HOH A . 
R 6 HOH 294 894  516 HOH HOH A . 
R 6 HOH 295 895  202 HOH HOH A . 
R 6 HOH 296 896  124 HOH HOH A . 
R 6 HOH 297 897  240 HOH HOH A . 
R 6 HOH 298 898  548 HOH HOH A . 
R 6 HOH 299 899  415 HOH HOH A . 
R 6 HOH 300 900  97  HOH HOH A . 
R 6 HOH 301 901  322 HOH HOH A . 
R 6 HOH 302 902  392 HOH HOH A . 
R 6 HOH 303 903  438 HOH HOH A . 
R 6 HOH 304 904  224 HOH HOH A . 
R 6 HOH 305 905  100 HOH HOH A . 
R 6 HOH 306 906  55  HOH HOH A . 
R 6 HOH 307 907  348 HOH HOH A . 
R 6 HOH 308 908  158 HOH HOH A . 
R 6 HOH 309 909  139 HOH HOH A . 
R 6 HOH 310 910  370 HOH HOH A . 
R 6 HOH 311 911  29  HOH HOH A . 
R 6 HOH 312 912  170 HOH HOH A . 
R 6 HOH 313 913  260 HOH HOH A . 
R 6 HOH 314 914  109 HOH HOH A . 
R 6 HOH 315 915  615 HOH HOH A . 
R 6 HOH 316 916  301 HOH HOH A . 
R 6 HOH 317 917  23  HOH HOH A . 
R 6 HOH 318 918  215 HOH HOH A . 
R 6 HOH 319 919  324 HOH HOH A . 
R 6 HOH 320 920  435 HOH HOH A . 
R 6 HOH 321 921  453 HOH HOH A . 
R 6 HOH 322 922  108 HOH HOH A . 
R 6 HOH 323 923  232 HOH HOH A . 
R 6 HOH 324 924  537 HOH HOH A . 
R 6 HOH 325 925  551 HOH HOH A . 
R 6 HOH 326 926  398 HOH HOH A . 
R 6 HOH 327 927  656 HOH HOH A . 
R 6 HOH 328 928  7   HOH HOH A . 
R 6 HOH 329 929  57  HOH HOH A . 
R 6 HOH 330 930  386 HOH HOH A . 
R 6 HOH 331 931  140 HOH HOH A . 
R 6 HOH 332 932  117 HOH HOH A . 
R 6 HOH 333 933  120 HOH HOH A . 
R 6 HOH 334 934  428 HOH HOH A . 
R 6 HOH 335 935  354 HOH HOH A . 
R 6 HOH 336 936  115 HOH HOH A . 
R 6 HOH 337 937  273 HOH HOH A . 
R 6 HOH 338 938  381 HOH HOH A . 
R 6 HOH 339 939  464 HOH HOH A . 
R 6 HOH 340 940  126 HOH HOH A . 
R 6 HOH 341 941  56  HOH HOH A . 
R 6 HOH 342 942  32  HOH HOH A . 
R 6 HOH 343 943  123 HOH HOH A . 
R 6 HOH 344 944  639 HOH HOH A . 
R 6 HOH 345 945  377 HOH HOH A . 
R 6 HOH 346 946  545 HOH HOH A . 
R 6 HOH 347 947  342 HOH HOH A . 
R 6 HOH 348 948  259 HOH HOH A . 
R 6 HOH 349 949  470 HOH HOH A . 
R 6 HOH 350 950  514 HOH HOH A . 
R 6 HOH 351 951  12  HOH HOH A . 
R 6 HOH 352 952  45  HOH HOH A . 
R 6 HOH 353 953  359 HOH HOH A . 
R 6 HOH 354 954  455 HOH HOH A . 
R 6 HOH 355 955  85  HOH HOH A . 
R 6 HOH 356 956  389 HOH HOH A . 
R 6 HOH 357 957  317 HOH HOH A . 
R 6 HOH 358 958  110 HOH HOH A . 
R 6 HOH 359 959  142 HOH HOH A . 
R 6 HOH 360 960  1   HOH HOH A . 
R 6 HOH 361 961  74  HOH HOH A . 
R 6 HOH 362 962  112 HOH HOH A . 
R 6 HOH 363 963  148 HOH HOH A . 
R 6 HOH 364 964  93  HOH HOH A . 
R 6 HOH 365 965  303 HOH HOH A . 
R 6 HOH 366 966  67  HOH HOH A . 
R 6 HOH 367 967  553 HOH HOH A . 
R 6 HOH 368 968  6   HOH HOH A . 
R 6 HOH 369 969  376 HOH HOH A . 
R 6 HOH 370 970  166 HOH HOH A . 
R 6 HOH 371 971  318 HOH HOH A . 
R 6 HOH 372 972  528 HOH HOH A . 
R 6 HOH 373 973  38  HOH HOH A . 
R 6 HOH 374 974  246 HOH HOH A . 
R 6 HOH 375 975  468 HOH HOH A . 
R 6 HOH 376 976  569 HOH HOH A . 
R 6 HOH 377 977  367 HOH HOH A . 
R 6 HOH 378 978  383 HOH HOH A . 
R 6 HOH 379 979  143 HOH HOH A . 
R 6 HOH 380 980  400 HOH HOH A . 
R 6 HOH 381 981  643 HOH HOH A . 
R 6 HOH 382 982  421 HOH HOH A . 
R 6 HOH 383 983  242 HOH HOH A . 
R 6 HOH 384 984  431 HOH HOH A . 
R 6 HOH 385 985  188 HOH HOH A . 
R 6 HOH 386 986  457 HOH HOH A . 
R 6 HOH 387 987  497 HOH HOH A . 
R 6 HOH 388 988  339 HOH HOH A . 
R 6 HOH 389 989  433 HOH HOH A . 
R 6 HOH 390 990  270 HOH HOH A . 
R 6 HOH 391 991  160 HOH HOH A . 
R 6 HOH 392 992  73  HOH HOH A . 
R 6 HOH 393 993  564 HOH HOH A . 
R 6 HOH 394 994  213 HOH HOH A . 
R 6 HOH 395 995  410 HOH HOH A . 
R 6 HOH 396 996  48  HOH HOH A . 
R 6 HOH 397 997  70  HOH HOH A . 
R 6 HOH 398 998  320 HOH HOH A . 
R 6 HOH 399 999  331 HOH HOH A . 
R 6 HOH 400 1000 71  HOH HOH A . 
R 6 HOH 401 1001 437 HOH HOH A . 
R 6 HOH 402 1002 95  HOH HOH A . 
R 6 HOH 403 1003 174 HOH HOH A . 
R 6 HOH 404 1004 62  HOH HOH A . 
R 6 HOH 405 1005 382 HOH HOH A . 
R 6 HOH 406 1006 352 HOH HOH A . 
R 6 HOH 407 1007 152 HOH HOH A . 
R 6 HOH 408 1008 539 HOH HOH A . 
R 6 HOH 409 1009 200 HOH HOH A . 
R 6 HOH 410 1010 343 HOH HOH A . 
R 6 HOH 411 1011 221 HOH HOH A . 
R 6 HOH 412 1012 132 HOH HOH A . 
R 6 HOH 413 1013 44  HOH HOH A . 
R 6 HOH 414 1014 63  HOH HOH A . 
R 6 HOH 415 1015 471 HOH HOH A . 
R 6 HOH 416 1016 79  HOH HOH A . 
R 6 HOH 417 1017 388 HOH HOH A . 
R 6 HOH 418 1018 111 HOH HOH A . 
R 6 HOH 419 1019 289 HOH HOH A . 
R 6 HOH 420 1020 651 HOH HOH A . 
R 6 HOH 421 1021 220 HOH HOH A . 
R 6 HOH 422 1022 675 HOH HOH A . 
R 6 HOH 423 1023 128 HOH HOH A . 
R 6 HOH 424 1024 171 HOH HOH A . 
R 6 HOH 425 1025 153 HOH HOH A . 
R 6 HOH 426 1026 243 HOH HOH A . 
R 6 HOH 427 1027 327 HOH HOH A . 
R 6 HOH 428 1028 346 HOH HOH A . 
R 6 HOH 429 1029 275 HOH HOH A . 
R 6 HOH 430 1030 244 HOH HOH A . 
R 6 HOH 431 1031 472 HOH HOH A . 
R 6 HOH 432 1032 636 HOH HOH A . 
R 6 HOH 433 1033 613 HOH HOH A . 
R 6 HOH 434 1034 513 HOH HOH A . 
R 6 HOH 435 1035 77  HOH HOH A . 
R 6 HOH 436 1036 378 HOH HOH A . 
R 6 HOH 437 1037 183 HOH HOH A . 
R 6 HOH 438 1038 287 HOH HOH A . 
R 6 HOH 439 1039 328 HOH HOH A . 
R 6 HOH 440 1040 418 HOH HOH A . 
R 6 HOH 441 1041 101 HOH HOH A . 
R 6 HOH 442 1042 34  HOH HOH A . 
R 6 HOH 443 1043 285 HOH HOH A . 
R 6 HOH 444 1044 75  HOH HOH A . 
R 6 HOH 445 1045 449 HOH HOH A . 
R 6 HOH 446 1046 249 HOH HOH A . 
R 6 HOH 447 1047 657 HOH HOH A . 
R 6 HOH 448 1048 503 HOH HOH A . 
R 6 HOH 449 1049 72  HOH HOH A . 
R 6 HOH 450 1050 209 HOH HOH A . 
R 6 HOH 451 1051 360 HOH HOH A . 
R 6 HOH 452 1052 125 HOH HOH A . 
R 6 HOH 453 1053 502 HOH HOH A . 
R 6 HOH 454 1054 578 HOH HOH A . 
R 6 HOH 455 1055 130 HOH HOH A . 
R 6 HOH 456 1056 4   HOH HOH A . 
R 6 HOH 457 1057 334 HOH HOH A . 
R 6 HOH 458 1058 436 HOH HOH A . 
R 6 HOH 459 1059 401 HOH HOH A . 
R 6 HOH 460 1060 674 HOH HOH A . 
R 6 HOH 461 1061 524 HOH HOH A . 
R 6 HOH 462 1062 277 HOH HOH A . 
R 6 HOH 463 1063 414 HOH HOH A . 
R 6 HOH 464 1064 49  HOH HOH A . 
R 6 HOH 465 1065 532 HOH HOH A . 
R 6 HOH 466 1066 669 HOH HOH A . 
R 6 HOH 467 1067 308 HOH HOH A . 
R 6 HOH 468 1068 507 HOH HOH A . 
R 6 HOH 469 1069 365 HOH HOH A . 
R 6 HOH 470 1070 176 HOH HOH A . 
R 6 HOH 471 1071 501 HOH HOH A . 
R 6 HOH 472 1072 252 HOH HOH A . 
R 6 HOH 473 1073 506 HOH HOH A . 
R 6 HOH 474 1074 531 HOH HOH A . 
R 6 HOH 475 1075 653 HOH HOH A . 
R 6 HOH 476 1076 422 HOH HOH A . 
R 6 HOH 477 1077 616 HOH HOH A . 
R 6 HOH 478 1078 81  HOH HOH A . 
R 6 HOH 479 1079 533 HOH HOH A . 
R 6 HOH 480 1080 530 HOH HOH A . 
R 6 HOH 481 1081 511 HOH HOH A . 
R 6 HOH 482 1082 508 HOH HOH A . 
R 6 HOH 483 1083 439 HOH HOH A . 
R 6 HOH 484 1084 302 HOH HOH A . 
R 6 HOH 485 1085 204 HOH HOH A . 
R 6 HOH 486 1086 664 HOH HOH A . 
R 6 HOH 487 1087 394 HOH HOH A . 
R 6 HOH 488 1088 446 HOH HOH A . 
R 6 HOH 489 1089 479 HOH HOH A . 
R 6 HOH 490 1090 509 HOH HOH A . 
R 6 HOH 491 1091 635 HOH HOH A . 
R 6 HOH 492 1092 184 HOH HOH A . 
R 6 HOH 493 1093 196 HOH HOH A . 
R 6 HOH 494 1094 500 HOH HOH A . 
R 6 HOH 495 1095 568 HOH HOH A . 
R 6 HOH 496 1096 456 HOH HOH A . 
R 6 HOH 497 1097 512 HOH HOH A . 
R 6 HOH 498 1098 662 HOH HOH A . 
R 6 HOH 499 1099 332 HOH HOH A . 
R 6 HOH 500 1100 284 HOH HOH A . 
R 6 HOH 501 1101 379 HOH HOH A . 
R 6 HOH 502 1102 637 HOH HOH A . 
R 6 HOH 503 1103 269 HOH HOH A . 
R 6 HOH 504 1104 644 HOH HOH A . 
R 6 HOH 505 1105 586 HOH HOH A . 
R 6 HOH 506 1106 465 HOH HOH A . 
R 6 HOH 507 1107 443 HOH HOH A . 
R 6 HOH 508 1108 558 HOH HOH A . 
R 6 HOH 509 1109 527 HOH HOH A . 
R 6 HOH 510 1110 278 HOH HOH A . 
R 6 HOH 511 1111 518 HOH HOH A . 
R 6 HOH 512 1112 579 HOH HOH A . 
R 6 HOH 513 1113 50  HOH HOH A . 
R 6 HOH 514 1114 369 HOH HOH A . 
R 6 HOH 515 1115 412 HOH HOH A . 
R 6 HOH 516 1116 487 HOH HOH A . 
R 6 HOH 517 1117 625 HOH HOH A . 
R 6 HOH 518 1118 618 HOH HOH A . 
R 6 HOH 519 1119 241 HOH HOH A . 
R 6 HOH 520 1120 673 HOH HOH A . 
R 6 HOH 521 1121 218 HOH HOH A . 
R 6 HOH 522 1122 676 HOH HOH A . 
R 6 HOH 523 1123 581 HOH HOH A . 
R 6 HOH 524 1124 567 HOH HOH A . 
R 6 HOH 525 1125 588 HOH HOH A . 
R 6 HOH 526 1126 199 HOH HOH A . 
R 6 HOH 527 1127 571 HOH HOH A . 
R 6 HOH 528 1128 294 HOH HOH A . 
R 6 HOH 529 1129 283 HOH HOH A . 
R 6 HOH 530 1130 631 HOH HOH A . 
R 6 HOH 531 1131 517 HOH HOH A . 
R 6 HOH 532 1132 608 HOH HOH A . 
R 6 HOH 533 1133 640 HOH HOH A . 
R 6 HOH 534 1134 520 HOH HOH A . 
R 6 HOH 535 1135 573 HOH HOH A . 
R 6 HOH 536 1136 655 HOH HOH A . 
R 6 HOH 537 1137 555 HOH HOH A . 
R 6 HOH 538 1138 621 HOH HOH A . 
R 6 HOH 539 1139 478 HOH HOH A . 
R 6 HOH 540 1140 476 HOH HOH A . 
R 6 HOH 541 1141 649 HOH HOH A . 
R 6 HOH 542 1142 290 HOH HOH A . 
R 6 HOH 543 1143 577 HOH HOH A . 
R 6 HOH 544 1144 266 HOH HOH A . 
R 6 HOH 545 1145 159 HOH HOH A . 
R 6 HOH 546 1146 482 HOH HOH A . 
R 6 HOH 547 1147 630 HOH HOH A . 
R 6 HOH 548 1148 593 HOH HOH A . 
R 6 HOH 549 1149 323 HOH HOH A . 
R 6 HOH 550 1150 566 HOH HOH A . 
R 6 HOH 551 1151 668 HOH HOH A . 
R 6 HOH 552 1152 642 HOH HOH A . 
R 6 HOH 553 1153 590 HOH HOH A . 
R 6 HOH 554 1154 663 HOH HOH A . 
R 6 HOH 555 1155 660 HOH HOH A . 
R 6 HOH 556 1156 423 HOH HOH A . 
R 6 HOH 557 1157 594 HOH HOH A . 
R 6 HOH 558 1158 350 HOH HOH A . 
R 6 HOH 559 1159 452 HOH HOH A . 
R 6 HOH 560 1160 665 HOH HOH A . 
R 6 HOH 561 1161 212 HOH HOH A . 
R 6 HOH 562 1162 596 HOH HOH A . 
R 6 HOH 563 1163 605 HOH HOH A . 
R 6 HOH 564 1164 251 HOH HOH A . 
R 6 HOH 565 1165 561 HOH HOH A . 
R 6 HOH 566 1166 572 HOH HOH A . 
R 6 HOH 567 1167 250 HOH HOH A . 
R 6 HOH 568 1168 610 HOH HOH A . 
R 6 HOH 569 1169 384 HOH HOH A . 
R 6 HOH 570 1170 265 HOH HOH A . 
R 6 HOH 571 1171 557 HOH HOH A . 
R 6 HOH 572 1172 647 HOH HOH A . 
R 6 HOH 573 1173 622 HOH HOH A . 
R 6 HOH 574 1174 413 HOH HOH A . 
R 6 HOH 575 1175 576 HOH HOH A . 
R 6 HOH 576 1176 483 HOH HOH A . 
R 6 HOH 577 1177 481 HOH HOH A . 
R 6 HOH 578 1178 556 HOH HOH A . 
R 6 HOH 579 1179 94  HOH HOH A . 
R 6 HOH 580 1180 192 HOH HOH A . 
R 6 HOH 581 1181 291 HOH HOH A . 
R 6 HOH 582 1182 612 HOH HOH A . 
R 6 HOH 583 1183 295 HOH HOH A . 
R 6 HOH 584 1184 427 HOH HOH A . 
R 6 HOH 585 1185 380 HOH HOH A . 
R 6 HOH 586 1186 197 HOH HOH A . 
R 6 HOH 587 1187 595 HOH HOH A . 
R 6 HOH 588 1188 430 HOH HOH A . 
R 6 HOH 589 1189 434 HOH HOH A . 
R 6 HOH 590 1190 484 HOH HOH A . 
R 6 HOH 591 1191 393 HOH HOH A . 
R 6 HOH 592 1192 560 HOH HOH A . 
R 6 HOH 593 1193 570 HOH HOH A . 
R 6 HOH 594 1194 591 HOH HOH A . 
R 6 HOH 595 1195 297 HOH HOH A . 
R 6 HOH 596 1196 492 HOH HOH A . 
R 6 HOH 597 1197 575 HOH HOH A . 
R 6 HOH 598 1198 629 HOH HOH A . 
R 6 HOH 599 1199 445 HOH HOH A . 
R 6 HOH 600 1200 626 HOH HOH A . 
R 6 HOH 601 1201 638 HOH HOH A . 
R 6 HOH 602 1202 628 HOH HOH A . 
R 6 HOH 603 1203 559 HOH HOH A . 
R 6 HOH 604 1204 35  HOH HOH A . 
R 6 HOH 605 1205 534 HOH HOH A . 
R 6 HOH 606 1206 477 HOH HOH A . 
R 6 HOH 607 1207 499 HOH HOH A . 
R 6 HOH 608 1208 167 HOH HOH A . 
R 6 HOH 609 1209 589 HOH HOH A . 
R 6 HOH 610 1210 441 HOH HOH A . 
R 6 HOH 611 1211 597 HOH HOH A . 
R 6 HOH 612 1212 549 HOH HOH A . 
R 6 HOH 613 1213 304 HOH HOH A . 
R 6 HOH 614 1214 623 HOH HOH A . 
R 6 HOH 615 1215 607 HOH HOH A . 
R 6 HOH 616 1216 155 HOH HOH A . 
R 6 HOH 617 1217 606 HOH HOH A . 
R 6 HOH 618 1218 584 HOH HOH A . 
R 6 HOH 619 1219 650 HOH HOH A . 
R 6 HOH 620 1220 271 HOH HOH A . 
R 6 HOH 621 1221 652 HOH HOH A . 
R 6 HOH 622 1222 600 HOH HOH A . 
R 6 HOH 623 1223 583 HOH HOH A . 
R 6 HOH 624 1224 486 HOH HOH A . 
R 6 HOH 625 1225 563 HOH HOH A . 
R 6 HOH 626 1226 627 HOH HOH A . 
R 6 HOH 627 1227 488 HOH HOH A . 
R 6 HOH 628 1228 554 HOH HOH A . 
R 6 HOH 629 1229 614 HOH HOH A . 
R 6 HOH 630 1230 41  HOH HOH A . 
R 6 HOH 631 1231 624 HOH HOH A . 
R 6 HOH 632 1232 300 HOH HOH A . 
R 6 HOH 633 1233 661 HOH HOH A . 
R 6 HOH 634 1234 228 HOH HOH A . 
R 6 HOH 635 1235 474 HOH HOH A . 
R 6 HOH 636 1236 351 HOH HOH A . 
R 6 HOH 637 1237 296 HOH HOH A . 
R 6 HOH 638 1238 255 HOH HOH A . 
R 6 HOH 639 1239 641 HOH HOH A . 
R 6 HOH 640 1240 658 HOH HOH A . 
R 6 HOH 641 1241 574 HOH HOH A . 
R 6 HOH 642 1242 485 HOH HOH A . 
R 6 HOH 643 1243 585 HOH HOH A . 
R 6 HOH 644 1244 645 HOH HOH A . 
R 6 HOH 645 1245 587 HOH HOH A . 
R 6 HOH 646 1246 671 HOH HOH A . 
R 6 HOH 647 1247 219 HOH HOH A . 
R 6 HOH 648 1248 493 HOH HOH A . 
R 6 HOH 649 1249 648 HOH HOH A . 
R 6 HOH 650 1250 580 HOH HOH A . 
R 6 HOH 651 1251 602 HOH HOH A . 
R 6 HOH 652 1252 489 HOH HOH A . 
R 6 HOH 653 1253 426 HOH HOH A . 
R 6 HOH 654 1254 617 HOH HOH A . 
R 6 HOH 655 1255 480 HOH HOH A . 
R 6 HOH 656 1256 264 HOH HOH A . 
R 6 HOH 657 1257 546 HOH HOH A . 
R 6 HOH 658 1258 667 HOH HOH A . 
R 6 HOH 659 1259 646 HOH HOH A . 
R 6 HOH 660 1260 60  HOH HOH A . 
R 6 HOH 661 1261 444 HOH HOH A . 
R 6 HOH 662 1262 592 HOH HOH A . 
R 6 HOH 663 1263 659 HOH HOH A . 
R 6 HOH 664 1264 490 HOH HOH A . 
R 6 HOH 665 1265 620 HOH HOH A . 
R 6 HOH 666 1266 654 HOH HOH A . 
R 6 HOH 667 1267 552 HOH HOH A . 
R 6 HOH 668 1268 417 HOH HOH A . 
R 6 HOH 669 1269 562 HOH HOH A . 
R 6 HOH 670 1270 582 HOH HOH A . 
R 6 HOH 671 1271 565 HOH HOH A . 
R 6 HOH 672 1272 121 HOH HOH A . 
R 6 HOH 673 1273 217 HOH HOH A . 
R 6 HOH 674 1274 210 HOH HOH A . 
R 6 HOH 675 1275 632 HOH HOH A . 
R 6 HOH 676 1276 473 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.39 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MM2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     43.297 
_cell.length_a_esd                 ? 
_cell.length_b                     61.950 
_cell.length_b_esd                 ? 
_cell.length_c                     77.369 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MM2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MM2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.03 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.29 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Ammonium chloride, 20 % w/v PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.953722 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.953722 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX1 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9MM2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.33 
_reflns.d_resolution_low                               47.66 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     89955 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          23.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.01 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.053 
_reflns.pdbx_Rpim_I_all                                0.020 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       624009 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.049 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.33 
_reflns_shell.d_res_low                                     1.35 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           30348 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4440 
_reflns_shell.percent_possible_obs                          98.4 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.8 
_reflns_shell.pdbx_chi_squared                              1.00 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     5.8 
_reflns_shell.pdbx_Rrim_I_all                               0.326 
_reflns_shell.pdbx_Rpim_I_all                               0.123 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.958 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.301 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.27 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            -0.17 
_refine.aniso_B[2][2]                            0.51 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -0.13 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               8.645 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.981 
_refine.correlation_coeff_Fo_to_Fc_free          0.973 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MM2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.33 
_refine.ls_d_res_low                             41.78 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     85488 
_refine.ls_number_reflns_R_free                  4444 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.34 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.12068 
_refine.ls_R_factor_R_free                       0.14014 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.11966 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.040 
_refine.pdbx_overall_ESU_R_Free                  0.042 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             0.557 
_refine.overall_SU_ML                            0.024 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.33 
_refine_hist.d_res_low                        41.78 
_refine_hist.number_atoms_solvent             676 
_refine_hist.number_atoms_total               3947 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3228 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         43 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.013 0.012  3486 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001 0.016  3082 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.899 1.800  4748 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.642 1.742  7136 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.265 5.000  460  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 8.469 5.000  12   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 9.987 10.000 553  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.098 0.200  521  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.011 0.020  4245 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002 0.020  801  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 0.857 0.799  1768 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 0.842 0.798  1767 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 1.255 1.438  2237 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 1.258 1.439  2238 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 1.664 0.946  1718 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.663 0.946  1719 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.424 1.652  2507 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 4.500 13.08  4285 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 3.927 9.40   4040 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?     ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.330 
_refine_ls_shell.d_res_low                        1.365 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             307 
_refine_ls_shell.number_reflns_R_work             6328 
_refine_ls_shell.percent_reflns_obs               99.18 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.154 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.173 
# 
_struct.entry_id                     9MM2 
_struct.title                        'Crystal structure of bacterial pectin methylesterase PmeC5 from B. fibrisolvens D1T' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MM2 
_struct_keywords.text            'Pectin methylesterase, SUGAR BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'SUGAR BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 5 ? 
R N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A1M6G673_BUTFI 
_struct_ref.pdbx_db_accession          A0A1M6G673 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKKASEESKIAYSEIITVGTDKDYKTISDAIEAIRHMERDDSQRVTIKIDPGNYQEMLIVDVDNVSLVNAAGDDASIELA
DSGVSVSDKAVRITSYYGHGYTYYSMGEDYRYDEEVLKVNQENGYPSVTNPGSGTATMWNATVYVNADGFEAEGIIFENS
FNQYVSELAAEDTIVAMEGAKEGSDGTRNDLEKGSTVVQQKSYVERASALALGNNLSDIVFTNCKVVGRQDTLYGGKMTY
AEFNNCEIYGAVDYIFGGMTAIFYQCELKFNTTDNKNDVGYITAAQQSSGRGYLMYECHITSVEAGTDVDSKYYSYTTSK
PGYFGRPWQANTSEVVFYNTTIDECDSTLASTYGSSSLIQPAGWLNSLGGEAQMYEYGTTESSGVDNSSARIASWTTWTT
SDSVLTTPYLADGTKITLDAFRKNKSG
;
_struct_ref.pdbx_align_begin           617 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MM2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 24 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 450 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A1M6G673 
_struct_ref_seq.db_align_beg                  617 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1043 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       427 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9MM2 MET A 1  ? UNP A0A1M6G673 ? ? 'initiating methionine' -22 1  
1 9MM2 GLY A 2  ? UNP A0A1M6G673 ? ? 'expression tag'        -21 2  
1 9MM2 SER A 3  ? UNP A0A1M6G673 ? ? 'expression tag'        -20 3  
1 9MM2 SER A 4  ? UNP A0A1M6G673 ? ? 'expression tag'        -19 4  
1 9MM2 HIS A 5  ? UNP A0A1M6G673 ? ? 'expression tag'        -18 5  
1 9MM2 HIS A 6  ? UNP A0A1M6G673 ? ? 'expression tag'        -17 6  
1 9MM2 HIS A 7  ? UNP A0A1M6G673 ? ? 'expression tag'        -16 7  
1 9MM2 HIS A 8  ? UNP A0A1M6G673 ? ? 'expression tag'        -15 8  
1 9MM2 HIS A 9  ? UNP A0A1M6G673 ? ? 'expression tag'        -14 9  
1 9MM2 HIS A 10 ? UNP A0A1M6G673 ? ? 'expression tag'        -13 10 
1 9MM2 SER A 11 ? UNP A0A1M6G673 ? ? 'expression tag'        -12 11 
1 9MM2 SER A 12 ? UNP A0A1M6G673 ? ? 'expression tag'        -11 12 
1 9MM2 GLY A 13 ? UNP A0A1M6G673 ? ? 'expression tag'        -10 13 
1 9MM2 LEU A 14 ? UNP A0A1M6G673 ? ? 'expression tag'        -9  14 
1 9MM2 VAL A 15 ? UNP A0A1M6G673 ? ? 'expression tag'        -8  15 
1 9MM2 PRO A 16 ? UNP A0A1M6G673 ? ? 'expression tag'        -7  16 
1 9MM2 ARG A 17 ? UNP A0A1M6G673 ? ? 'expression tag'        -6  17 
1 9MM2 GLY A 18 ? UNP A0A1M6G673 ? ? 'expression tag'        -5  18 
1 9MM2 SER A 19 ? UNP A0A1M6G673 ? ? 'expression tag'        -4  19 
1 9MM2 HIS A 20 ? UNP A0A1M6G673 ? ? 'expression tag'        -3  20 
1 9MM2 MET A 21 ? UNP A0A1M6G673 ? ? 'expression tag'        -2  21 
1 9MM2 LEU A 22 ? UNP A0A1M6G673 ? ? 'expression tag'        -1  22 
1 9MM2 GLU A 23 ? UNP A0A1M6G673 ? ? 'expression tag'        0   23 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 49  ? HIS A 59  ? THR A 26  HIS A 36  1 ? 11 
HELX_P HELX_P2  AA2 ALA A 94  ? ALA A 98  ? ALA A 71  ALA A 75  5 ? 5  
HELX_P HELX_P3  AA3 ASP A 104 ? VAL A 107 ? ASP A 81  VAL A 84  5 ? 4  
HELX_P HELX_P4  AA4 ASP A 136 ? GLY A 147 ? ASP A 113 GLY A 124 1 ? 12 
HELX_P HELX_P5  AA5 SER A 189 ? ASP A 195 ? SER A 166 ASP A 172 1 ? 7  
HELX_P HELX_P6  AA6 THR A 210 ? LEU A 214 ? THR A 187 LEU A 191 5 ? 5  
HELX_P HELX_P7  AA7 THR A 219 ? VAL A 227 ? THR A 196 VAL A 204 5 ? 9  
HELX_P HELX_P8  AA8 ASP A 333 ? TYR A 337 ? ASP A 310 TYR A 314 5 ? 5  
HELX_P HELX_P9  AA9 ASP A 369 ? GLY A 377 ? ASP A 346 GLY A 354 1 ? 9  
HELX_P HELX_P10 AB1 ASN A 410 ? ARG A 414 ? ASN A 387 ARG A 391 5 ? 5  
HELX_P HELX_P11 AB2 THR A 422 ? VAL A 427 ? THR A 399 VAL A 404 1 ? 6  
HELX_P HELX_P12 AB3 LEU A 441 ? ARG A 445 ? LEU A 418 ARG A 422 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A PRO 154 O   ? ? ? 1_555 G NA  . NA ? ? A PRO 131 A NA  506  1_555 ? ? ? ? ? ? ? 2.788 ? ? 
metalc2  metalc ? ? A SER 156 O   ? ? ? 1_555 G NA  . NA ? ? A SER 133 A NA  506  1_555 ? ? ? ? ? ? ? 3.075 ? ? 
metalc3  metalc ? ? A SER 156 OG  ? ? ? 1_555 G NA  . NA ? ? A SER 133 A NA  506  1_555 ? ? ? ? ? ? ? 2.927 ? ? 
metalc4  metalc ? ? A GLY 202 O   ? ? ? 1_555 C MG  . MG ? ? A GLY 179 A MG  502  1_555 ? ? ? ? ? ? ? 2.671 ? ? 
metalc5  metalc ? ? A LYS 204 NZ  ? ? ? 1_555 C MG  . MG ? ? A LYS 181 A MG  502  1_555 ? ? ? ? ? ? ? 2.831 ? ? 
metalc6  metalc ? ? A ARG 211 NH1 ? ? ? 1_555 B MG  . MG ? ? A ARG 188 A MG  501  1_555 ? ? ? ? ? ? ? 2.982 ? ? 
metalc7  metalc ? ? A GLU 228 OE1 ? ? ? 1_555 C MG  . MG ? ? A GLU 205 A MG  502  1_555 ? ? ? ? ? ? ? 2.664 ? ? 
metalc8  metalc ? ? A GLY 401 N   ? ? ? 1_555 D MG  . MG ? ? A GLY 378 A MG  503  1_555 ? ? ? ? ? ? ? 2.888 ? ? 
metalc9  metalc ? ? A LEU 428 O   ? ? ? 1_555 D MG  . MG ? ? A LEU 405 A MG  503  1_555 ? ? ? ? ? ? ? 2.667 ? ? 
metalc10 metalc ? ? B MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  501 A HOH 720  1_555 ? ? ? ? ? ? ? 2.818 ? ? 
metalc11 metalc ? ? B MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  501 A HOH 962  1_555 ? ? ? ? ? ? ? 2.797 ? ? 
metalc12 metalc ? ? B MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  501 A HOH 1057 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc13 metalc ? ? C MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  502 A HOH 1204 1_555 ? ? ? ? ? ? ? 2.711 ? ? 
metalc14 metalc ? ? D MG  .   MG  ? ? ? 1_555 R HOH . O  ? ? A MG  503 A HOH 1032 2_545 ? ? ? ? ? ? ? 2.426 ? ? 
metalc15 metalc ? ? E NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  504 A HOH 703  1_555 ? ? ? ? ? ? ? 2.841 ? ? 
metalc16 metalc ? ? E NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  504 A HOH 760  1_555 ? ? ? ? ? ? ? 2.870 ? ? 
metalc17 metalc ? ? F NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  505 A HOH 892  1_555 ? ? ? ? ? ? ? 2.942 ? ? 
metalc18 metalc ? ? F NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  505 A HOH 992  1_555 ? ? ? ? ? ? ? 3.050 ? ? 
metalc19 metalc ? ? F NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  505 A HOH 1122 1_555 ? ? ? ? ? ? ? 2.319 ? ? 
metalc20 metalc ? ? G NA  .   NA  ? ? ? 1_555 R HOH . O  ? ? A NA  506 A HOH 607  1_555 ? ? ? ? ? ? ? 2.603 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A PRO 154 ? A PRO 131 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 O   ? A SER 156 ? A SER 133  ? 1_555 91.0  ? 
2  O   ? A PRO 154 ? A PRO 131 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 OG  ? A SER 156 ? A SER 133  ? 1_555 123.3 ? 
3  O   ? A SER 156 ? A SER 133 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 OG  ? A SER 156 ? A SER 133  ? 1_555 59.0  ? 
4  O   ? A PRO 154 ? A PRO 131 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 O   ? R HOH .   ? A HOH 607  ? 1_555 152.6 ? 
5  O   ? A SER 156 ? A SER 133 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 O   ? R HOH .   ? A HOH 607  ? 1_555 104.0 ? 
6  OG  ? A SER 156 ? A SER 133 ? 1_555 NA ? G NA . ? A NA 506 ? 1_555 O   ? R HOH .   ? A HOH 607  ? 1_555 52.3  ? 
7  O   ? A GLY 202 ? A GLY 179 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 NZ  ? A LYS 204 ? A LYS 181  ? 1_555 112.3 ? 
8  O   ? A GLY 202 ? A GLY 179 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 OE1 ? A GLU 228 ? A GLU 205  ? 1_555 108.5 ? 
9  NZ  ? A LYS 204 ? A LYS 181 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 OE1 ? A GLU 228 ? A GLU 205  ? 1_555 122.8 ? 
10 O   ? A GLY 202 ? A GLY 179 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 O   ? R HOH .   ? A HOH 1204 ? 1_555 115.2 ? 
11 NZ  ? A LYS 204 ? A LYS 181 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 O   ? R HOH .   ? A HOH 1204 ? 1_555 96.9  ? 
12 OE1 ? A GLU 228 ? A GLU 205 ? 1_555 MG ? C MG . ? A MG 502 ? 1_555 O   ? R HOH .   ? A HOH 1204 ? 1_555 100.3 ? 
13 NH1 ? A ARG 211 ? A ARG 188 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 720  ? 1_555 77.4  ? 
14 NH1 ? A ARG 211 ? A ARG 188 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 962  ? 1_555 111.6 ? 
15 O   ? R HOH .   ? A HOH 720 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 962  ? 1_555 127.8 ? 
16 NH1 ? A ARG 211 ? A ARG 188 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 1057 ? 1_555 71.5  ? 
17 O   ? R HOH .   ? A HOH 720 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 1057 ? 1_555 104.1 ? 
18 O   ? R HOH .   ? A HOH 962 ? 1_555 MG ? B MG . ? A MG 501 ? 1_555 O   ? R HOH .   ? A HOH 1057 ? 1_555 127.8 ? 
19 N   ? A GLY 401 ? A GLY 378 ? 1_555 MG ? D MG . ? A MG 503 ? 1_555 O   ? A LEU 428 ? A LEU 405  ? 1_555 122.5 ? 
20 N   ? A GLY 401 ? A GLY 378 ? 1_555 MG ? D MG . ? A MG 503 ? 1_555 O   ? R HOH .   ? A HOH 1032 ? 2_545 93.8  ? 
21 O   ? A LEU 428 ? A LEU 405 ? 1_555 MG ? D MG . ? A MG 503 ? 1_555 O   ? R HOH .   ? A HOH 1032 ? 2_545 110.3 ? 
22 O   ? R HOH .   ? A HOH 703 ? 1_555 NA ? E NA . ? A NA 504 ? 1_555 O   ? R HOH .   ? A HOH 760  ? 1_555 78.6  ? 
23 O   ? R HOH .   ? A HOH 892 ? 1_555 NA ? F NA . ? A NA 505 ? 1_555 O   ? R HOH .   ? A HOH 992  ? 1_555 108.5 ? 
24 O   ? R HOH .   ? A HOH 892 ? 1_555 NA ? F NA . ? A NA 505 ? 1_555 O   ? R HOH .   ? A HOH 1122 ? 1_555 113.7 ? 
25 O   ? R HOH .   ? A HOH 992 ? 1_555 NA ? F NA . ? A NA 505 ? 1_555 O   ? R HOH .   ? A HOH 1122 ? 1_555 100.9 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2  ? 
AA2 ? 10 ? 
AA3 ? 9  ? 
AA4 ? 7  ? 
AA5 ? 2  ? 
AA6 ? 2  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA2 1 2  ? parallel      
AA2 2 3  ? parallel      
AA2 3 4  ? parallel      
AA2 4 5  ? parallel      
AA2 5 6  ? parallel      
AA2 6 7  ? parallel      
AA2 7 8  ? parallel      
AA2 8 9  ? parallel      
AA2 9 10 ? parallel      
AA3 1 2  ? parallel      
AA3 2 3  ? parallel      
AA3 3 4  ? parallel      
AA3 4 5  ? parallel      
AA3 5 6  ? parallel      
AA3 6 7  ? parallel      
AA3 7 8  ? parallel      
AA3 8 9  ? parallel      
AA4 1 2  ? parallel      
AA4 2 3  ? parallel      
AA4 3 4  ? parallel      
AA4 4 5  ? parallel      
AA4 5 6  ? parallel      
AA4 6 7  ? parallel      
AA5 1 2  ? anti-parallel 
AA6 1 2  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ILE A 33  ? ALA A 34  ? ILE A 10  ALA A 11  
AA1 2  MET A 60  ? GLU A 61  ? MET A 37  GLU A 38  
AA2 1  ILE A 38  ? VAL A 41  ? ILE A 15  VAL A 18  
AA2 2  VAL A 68  ? ILE A 72  ? VAL A 45  ILE A 49  
AA2 3  VAL A 88  ? ASN A 92  ? VAL A 65  ASN A 69  
AA2 4  GLU A 174 ? GLU A 176 ? GLU A 151 GLU A 153 
AA2 5  ILE A 242 ? THR A 245 ? ILE A 219 THR A 222 
AA2 6  TYR A 263 ? ASN A 267 ? TYR A 240 ASN A 244 
AA2 7  THR A 283 ? TYR A 287 ? THR A 260 TYR A 264 
AA2 8  TYR A 316 ? TYR A 319 ? TYR A 293 TYR A 296 
AA2 9  GLU A 357 ? TYR A 361 ? GLU A 334 TYR A 338 
AA2 10 GLN A 396 ? TYR A 400 ? GLN A 373 TYR A 377 
AA3 1  GLY A 75  ? GLN A 78  ? GLY A 52  GLN A 55  
AA3 2  VAL A 114 ? SER A 118 ? VAL A 91  SER A 95  
AA3 3  ILE A 178 ? ASN A 182 ? ILE A 155 ASN A 159 
AA3 4  LYS A 248 ? VAL A 250 ? LYS A 225 VAL A 227 
AA3 5  GLU A 270 ? GLY A 273 ? GLU A 247 GLY A 250 
AA3 6  GLU A 290 ? PHE A 293 ? GLU A 267 PHE A 270 
AA3 7  HIS A 322 ? SER A 325 ? HIS A 299 SER A 302 
AA3 8  THR A 364 ? ILE A 365 ? THR A 341 ILE A 342 
AA3 9  THR A 403 ? GLU A 404 ? THR A 380 GLU A 381 
AA4 1  LEU A 81  ? VAL A 83  ? LEU A 58  VAL A 60  
AA4 2  VAL A 166 ? VAL A 168 ? VAL A 143 VAL A 145 
AA4 3  LEU A 233 ? LEU A 235 ? LEU A 210 LEU A 212 
AA4 4  LEU A 256 ? GLY A 258 ? LEU A 233 GLY A 235 
AA4 5  VAL A 275 ? GLY A 280 ? VAL A 252 GLY A 257 
AA4 6  TYR A 304 ? ALA A 308 ? TYR A 281 ALA A 285 
AA4 7  TYR A 346 ? GLY A 348 ? TYR A 323 GLY A 325 
AA5 1  LEU A 102 ? ALA A 103 ? LEU A 79  ALA A 80  
AA5 2  SER A 108 ? VAL A 109 ? SER A 85  VAL A 86  
AA6 1  TYR A 124 ? TYR A 126 ? TYR A 101 TYR A 103 
AA6 2  ILE A 197 ? ALA A 199 ? ILE A 174 ALA A 176 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ILE A 33  ? N ILE A 10  O GLU A 61  ? O GLU A 38  
AA2 1 2  N ILE A 39  ? N ILE A 16  O LYS A 71  ? O LYS A 48  
AA2 2 3  N ILE A 70  ? N ILE A 47  O SER A 89  ? O SER A 66  
AA2 3 4  N LEU A 90  ? N LEU A 67  O GLU A 176 ? O GLU A 153 
AA2 4 5  N ALA A 175 ? N ALA A 152 O THR A 245 ? O THR A 222 
AA2 5 6  N PHE A 244 ? N PHE A 221 O ASN A 267 ? O ASN A 244 
AA2 6 7  N PHE A 266 ? N PHE A 243 O TYR A 287 ? O TYR A 264 
AA2 7 8  N ALA A 284 ? N ALA A 261 O LEU A 317 ? O LEU A 294 
AA2 8 9  N MET A 318 ? N MET A 295 O VAL A 359 ? O VAL A 336 
AA2 9 10 N VAL A 358 ? N VAL A 335 O TYR A 398 ? O TYR A 375 
AA3 1 2  N TYR A 77  ? N TYR A 54  O ARG A 115 ? O ARG A 92  
AA3 2 3  N VAL A 114 ? N VAL A 91  O ILE A 179 ? O ILE A 156 
AA3 3 4  N PHE A 180 ? N PHE A 157 O LYS A 248 ? O LYS A 225 
AA3 4 5  N VAL A 249 ? N VAL A 226 O TYR A 272 ? O TYR A 249 
AA3 5 6  N ILE A 271 ? N ILE A 248 O LYS A 292 ? O LYS A 269 
AA3 6 7  N LEU A 291 ? N LEU A 268 O HIS A 322 ? O HIS A 299 
AA3 7 8  N ILE A 323 ? N ILE A 300 O THR A 364 ? O THR A 341 
AA3 8 9  N ILE A 365 ? N ILE A 342 O THR A 403 ? O THR A 380 
AA4 1 2  N VAL A 83  ? N VAL A 60  O TYR A 167 ? O TYR A 144 
AA4 2 3  N VAL A 168 ? N VAL A 145 O ALA A 234 ? O ALA A 211 
AA4 3 4  N LEU A 235 ? N LEU A 212 O TYR A 257 ? O TYR A 234 
AA4 4 5  N LEU A 256 ? N LEU A 233 O PHE A 279 ? O PHE A 256 
AA4 5 6  N ILE A 278 ? N ILE A 255 O ALA A 307 ? O ALA A 284 
AA4 6 7  N ILE A 305 ? N ILE A 282 O TYR A 346 ? O TYR A 323 
AA5 1 2  N ALA A 103 ? N ALA A 80  O SER A 108 ? O SER A 85  
AA6 1 2  N THR A 125 ? N THR A 102 O VAL A 198 ? O VAL A 175 
# 
_pdbx_entry_details.entry_id                   9MM2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 MET A 177 ? ? -128.50 -161.51 
2  1 ALA A 207 ? ? -160.83 99.80   
3  1 ALA A 207 ? ? -160.83 99.50   
4  1 ARG A 229 ? ? -122.26 -82.85  
5  1 ALA A 251 ? ? -125.79 -100.54 
6  1 THR A 307 ? A -99.24  -60.77  
7  1 THR A 307 ? B -93.45  -64.89  
8  1 ASN A 331 ? ? 71.10   -46.65  
9  1 ASP A 346 ? ? -38.70  131.23  
10 1 LEU A 368 ? A -95.97  -94.34  
11 1 LEU A 368 ? B -102.85 -80.85  
12 1 ALA A 372 ? ? -164.13 -168.11 
13 1 ALA A 372 ? ? -164.13 -169.92 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     44 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.083 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1275 ? 6.04 . 
2 1 O ? A HOH 1276 ? 6.12 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -22 ? A MET 1  
2  1 Y 1 A GLY -21 ? A GLY 2  
3  1 Y 1 A SER -20 ? A SER 3  
4  1 Y 1 A SER -19 ? A SER 4  
5  1 Y 1 A HIS -18 ? A HIS 5  
6  1 Y 1 A HIS -17 ? A HIS 6  
7  1 Y 1 A HIS -16 ? A HIS 7  
8  1 Y 1 A HIS -15 ? A HIS 8  
9  1 Y 1 A HIS -14 ? A HIS 9  
10 1 Y 1 A HIS -13 ? A HIS 10 
11 1 Y 1 A SER -12 ? A SER 11 
12 1 Y 1 A SER -11 ? A SER 12 
13 1 Y 1 A GLY -10 ? A GLY 13 
14 1 Y 1 A LEU -9  ? A LEU 14 
15 1 Y 1 A VAL -8  ? A VAL 15 
16 1 Y 1 A PRO -7  ? A PRO 16 
17 1 Y 1 A ARG -6  ? A ARG 17 
18 1 Y 1 A GLY -5  ? A GLY 18 
19 1 Y 1 A SER -4  ? A SER 19 
20 1 Y 1 A HIS -3  ? A HIS 20 
21 1 Y 1 A MET -2  ? A MET 21 
22 1 Y 1 A LEU -1  ? A LEU 22 
23 1 Y 1 A GLU 0   ? A GLU 23 
24 1 Y 1 A MET 1   ? A MET 24 
25 1 Y 1 A LYS 2   ? A LYS 25 
26 1 Y 1 A LYS 3   ? A LYS 26 
27 1 Y 1 A ALA 4   ? A ALA 27 
28 1 Y 1 A SER 5   ? A SER 28 
29 1 Y 1 A GLU 6   ? A GLU 29 
30 1 Y 1 A GLU 7   ? A GLU 30 
31 1 Y 1 A SER 8   ? A SER 31 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
EDO C1   C  N N 88  
EDO O1   O  N N 89  
EDO C2   C  N N 90  
EDO O2   O  N N 91  
EDO H11  H  N N 92  
EDO H12  H  N N 93  
EDO HO1  H  N N 94  
EDO H21  H  N N 95  
EDO H22  H  N N 96  
EDO HO2  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
LEU N    N  N N 193 
LEU CA   C  N S 194 
LEU C    C  N N 195 
LEU O    O  N N 196 
LEU CB   C  N N 197 
LEU CG   C  N N 198 
LEU CD1  C  N N 199 
LEU CD2  C  N N 200 
LEU OXT  O  N N 201 
LEU H    H  N N 202 
LEU H2   H  N N 203 
LEU HA   H  N N 204 
LEU HB2  H  N N 205 
LEU HB3  H  N N 206 
LEU HG   H  N N 207 
LEU HD11 H  N N 208 
LEU HD12 H  N N 209 
LEU HD13 H  N N 210 
LEU HD21 H  N N 211 
LEU HD22 H  N N 212 
LEU HD23 H  N N 213 
LEU HXT  H  N N 214 
LYS N    N  N N 215 
LYS CA   C  N S 216 
LYS C    C  N N 217 
LYS O    O  N N 218 
LYS CB   C  N N 219 
LYS CG   C  N N 220 
LYS CD   C  N N 221 
LYS CE   C  N N 222 
LYS NZ   N  N N 223 
LYS OXT  O  N N 224 
LYS H    H  N N 225 
LYS H2   H  N N 226 
LYS HA   H  N N 227 
LYS HB2  H  N N 228 
LYS HB3  H  N N 229 
LYS HG2  H  N N 230 
LYS HG3  H  N N 231 
LYS HD2  H  N N 232 
LYS HD3  H  N N 233 
LYS HE2  H  N N 234 
LYS HE3  H  N N 235 
LYS HZ1  H  N N 236 
LYS HZ2  H  N N 237 
LYS HZ3  H  N N 238 
LYS HXT  H  N N 239 
MET N    N  N N 240 
MET CA   C  N S 241 
MET C    C  N N 242 
MET O    O  N N 243 
MET CB   C  N N 244 
MET CG   C  N N 245 
MET SD   S  N N 246 
MET CE   C  N N 247 
MET OXT  O  N N 248 
MET H    H  N N 249 
MET H2   H  N N 250 
MET HA   H  N N 251 
MET HB2  H  N N 252 
MET HB3  H  N N 253 
MET HG2  H  N N 254 
MET HG3  H  N N 255 
MET HE1  H  N N 256 
MET HE2  H  N N 257 
MET HE3  H  N N 258 
MET HXT  H  N N 259 
MG  MG   MG N N 260 
NA  NA   NA N N 261 
NH4 N    N  N N 262 
NH4 HN1  H  N N 263 
NH4 HN2  H  N N 264 
NH4 HN3  H  N N 265 
NH4 HN4  H  N N 266 
PHE N    N  N N 267 
PHE CA   C  N S 268 
PHE C    C  N N 269 
PHE O    O  N N 270 
PHE CB   C  N N 271 
PHE CG   C  Y N 272 
PHE CD1  C  Y N 273 
PHE CD2  C  Y N 274 
PHE CE1  C  Y N 275 
PHE CE2  C  Y N 276 
PHE CZ   C  Y N 277 
PHE OXT  O  N N 278 
PHE H    H  N N 279 
PHE H2   H  N N 280 
PHE HA   H  N N 281 
PHE HB2  H  N N 282 
PHE HB3  H  N N 283 
PHE HD1  H  N N 284 
PHE HD2  H  N N 285 
PHE HE1  H  N N 286 
PHE HE2  H  N N 287 
PHE HZ   H  N N 288 
PHE HXT  H  N N 289 
PRO N    N  N N 290 
PRO CA   C  N S 291 
PRO C    C  N N 292 
PRO O    O  N N 293 
PRO CB   C  N N 294 
PRO CG   C  N N 295 
PRO CD   C  N N 296 
PRO OXT  O  N N 297 
PRO H    H  N N 298 
PRO HA   H  N N 299 
PRO HB2  H  N N 300 
PRO HB3  H  N N 301 
PRO HG2  H  N N 302 
PRO HG3  H  N N 303 
PRO HD2  H  N N 304 
PRO HD3  H  N N 305 
PRO HXT  H  N N 306 
SER N    N  N N 307 
SER CA   C  N S 308 
SER C    C  N N 309 
SER O    O  N N 310 
SER CB   C  N N 311 
SER OG   O  N N 312 
SER OXT  O  N N 313 
SER H    H  N N 314 
SER H2   H  N N 315 
SER HA   H  N N 316 
SER HB2  H  N N 317 
SER HB3  H  N N 318 
SER HG   H  N N 319 
SER HXT  H  N N 320 
THR N    N  N N 321 
THR CA   C  N S 322 
THR C    C  N N 323 
THR O    O  N N 324 
THR CB   C  N R 325 
THR OG1  O  N N 326 
THR CG2  C  N N 327 
THR OXT  O  N N 328 
THR H    H  N N 329 
THR H2   H  N N 330 
THR HA   H  N N 331 
THR HB   H  N N 332 
THR HG1  H  N N 333 
THR HG21 H  N N 334 
THR HG22 H  N N 335 
THR HG23 H  N N 336 
THR HXT  H  N N 337 
TRP N    N  N N 338 
TRP CA   C  N S 339 
TRP C    C  N N 340 
TRP O    O  N N 341 
TRP CB   C  N N 342 
TRP CG   C  Y N 343 
TRP CD1  C  Y N 344 
TRP CD2  C  Y N 345 
TRP NE1  N  Y N 346 
TRP CE2  C  Y N 347 
TRP CE3  C  Y N 348 
TRP CZ2  C  Y N 349 
TRP CZ3  C  Y N 350 
TRP CH2  C  Y N 351 
TRP OXT  O  N N 352 
TRP H    H  N N 353 
TRP H2   H  N N 354 
TRP HA   H  N N 355 
TRP HB2  H  N N 356 
TRP HB3  H  N N 357 
TRP HD1  H  N N 358 
TRP HE1  H  N N 359 
TRP HE3  H  N N 360 
TRP HZ2  H  N N 361 
TRP HZ3  H  N N 362 
TRP HH2  H  N N 363 
TRP HXT  H  N N 364 
TYR N    N  N N 365 
TYR CA   C  N S 366 
TYR C    C  N N 367 
TYR O    O  N N 368 
TYR CB   C  N N 369 
TYR CG   C  Y N 370 
TYR CD1  C  Y N 371 
TYR CD2  C  Y N 372 
TYR CE1  C  Y N 373 
TYR CE2  C  Y N 374 
TYR CZ   C  Y N 375 
TYR OH   O  N N 376 
TYR OXT  O  N N 377 
TYR H    H  N N 378 
TYR H2   H  N N 379 
TYR HA   H  N N 380 
TYR HB2  H  N N 381 
TYR HB3  H  N N 382 
TYR HD1  H  N N 383 
TYR HD2  H  N N 384 
TYR HE1  H  N N 385 
TYR HE2  H  N N 386 
TYR HH   H  N N 387 
TYR HXT  H  N N 388 
VAL N    N  N N 389 
VAL CA   C  N S 390 
VAL C    C  N N 391 
VAL O    O  N N 392 
VAL CB   C  N N 393 
VAL CG1  C  N N 394 
VAL CG2  C  N N 395 
VAL OXT  O  N N 396 
VAL H    H  N N 397 
VAL H2   H  N N 398 
VAL HA   H  N N 399 
VAL HB   H  N N 400 
VAL HG11 H  N N 401 
VAL HG12 H  N N 402 
VAL HG13 H  N N 403 
VAL HG21 H  N N 404 
VAL HG22 H  N N 405 
VAL HG23 H  N N 406 
VAL HXT  H  N N 407 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NH4 N   HN1  sing N N 246 
NH4 N   HN2  sing N N 247 
NH4 N   HN3  sing N N 248 
NH4 N   HN4  sing N N 249 
PHE N   CA   sing N N 250 
PHE N   H    sing N N 251 
PHE N   H2   sing N N 252 
PHE CA  C    sing N N 253 
PHE CA  CB   sing N N 254 
PHE CA  HA   sing N N 255 
PHE C   O    doub N N 256 
PHE C   OXT  sing N N 257 
PHE CB  CG   sing N N 258 
PHE CB  HB2  sing N N 259 
PHE CB  HB3  sing N N 260 
PHE CG  CD1  doub Y N 261 
PHE CG  CD2  sing Y N 262 
PHE CD1 CE1  sing Y N 263 
PHE CD1 HD1  sing N N 264 
PHE CD2 CE2  doub Y N 265 
PHE CD2 HD2  sing N N 266 
PHE CE1 CZ   doub Y N 267 
PHE CE1 HE1  sing N N 268 
PHE CE2 CZ   sing Y N 269 
PHE CE2 HE2  sing N N 270 
PHE CZ  HZ   sing N N 271 
PHE OXT HXT  sing N N 272 
PRO N   CA   sing N N 273 
PRO N   CD   sing N N 274 
PRO N   H    sing N N 275 
PRO CA  C    sing N N 276 
PRO CA  CB   sing N N 277 
PRO CA  HA   sing N N 278 
PRO C   O    doub N N 279 
PRO C   OXT  sing N N 280 
PRO CB  CG   sing N N 281 
PRO CB  HB2  sing N N 282 
PRO CB  HB3  sing N N 283 
PRO CG  CD   sing N N 284 
PRO CG  HG2  sing N N 285 
PRO CG  HG3  sing N N 286 
PRO CD  HD2  sing N N 287 
PRO CD  HD3  sing N N 288 
PRO OXT HXT  sing N N 289 
SER N   CA   sing N N 290 
SER N   H    sing N N 291 
SER N   H2   sing N N 292 
SER CA  C    sing N N 293 
SER CA  CB   sing N N 294 
SER CA  HA   sing N N 295 
SER C   O    doub N N 296 
SER C   OXT  sing N N 297 
SER CB  OG   sing N N 298 
SER CB  HB2  sing N N 299 
SER CB  HB3  sing N N 300 
SER OG  HG   sing N N 301 
SER OXT HXT  sing N N 302 
THR N   CA   sing N N 303 
THR N   H    sing N N 304 
THR N   H2   sing N N 305 
THR CA  C    sing N N 306 
THR CA  CB   sing N N 307 
THR CA  HA   sing N N 308 
THR C   O    doub N N 309 
THR C   OXT  sing N N 310 
THR CB  OG1  sing N N 311 
THR CB  CG2  sing N N 312 
THR CB  HB   sing N N 313 
THR OG1 HG1  sing N N 314 
THR CG2 HG21 sing N N 315 
THR CG2 HG22 sing N N 316 
THR CG2 HG23 sing N N 317 
THR OXT HXT  sing N N 318 
TRP N   CA   sing N N 319 
TRP N   H    sing N N 320 
TRP N   H2   sing N N 321 
TRP CA  C    sing N N 322 
TRP CA  CB   sing N N 323 
TRP CA  HA   sing N N 324 
TRP C   O    doub N N 325 
TRP C   OXT  sing N N 326 
TRP CB  CG   sing N N 327 
TRP CB  HB2  sing N N 328 
TRP CB  HB3  sing N N 329 
TRP CG  CD1  doub Y N 330 
TRP CG  CD2  sing Y N 331 
TRP CD1 NE1  sing Y N 332 
TRP CD1 HD1  sing N N 333 
TRP CD2 CE2  doub Y N 334 
TRP CD2 CE3  sing Y N 335 
TRP NE1 CE2  sing Y N 336 
TRP NE1 HE1  sing N N 337 
TRP CE2 CZ2  sing Y N 338 
TRP CE3 CZ3  doub Y N 339 
TRP CE3 HE3  sing N N 340 
TRP CZ2 CH2  doub Y N 341 
TRP CZ2 HZ2  sing N N 342 
TRP CZ3 CH2  sing Y N 343 
TRP CZ3 HZ3  sing N N 344 
TRP CH2 HH2  sing N N 345 
TRP OXT HXT  sing N N 346 
TYR N   CA   sing N N 347 
TYR N   H    sing N N 348 
TYR N   H2   sing N N 349 
TYR CA  C    sing N N 350 
TYR CA  CB   sing N N 351 
TYR CA  HA   sing N N 352 
TYR C   O    doub N N 353 
TYR C   OXT  sing N N 354 
TYR CB  CG   sing N N 355 
TYR CB  HB2  sing N N 356 
TYR CB  HB3  sing N N 357 
TYR CG  CD1  doub Y N 358 
TYR CG  CD2  sing Y N 359 
TYR CD1 CE1  sing Y N 360 
TYR CD1 HD1  sing N N 361 
TYR CD2 CE2  doub Y N 362 
TYR CD2 HD2  sing N N 363 
TYR CE1 CZ   doub Y N 364 
TYR CE1 HE1  sing N N 365 
TYR CE2 CZ   sing Y N 366 
TYR CE2 HE2  sing N N 367 
TYR CZ  OH   sing N N 368 
TYR OH  HH   sing N N 369 
TYR OXT HXT  sing N N 370 
VAL N   CA   sing N N 371 
VAL N   H    sing N N 372 
VAL N   H2   sing N N 373 
VAL CA  C    sing N N 374 
VAL CA  CB   sing N N 375 
VAL CA  HA   sing N N 376 
VAL C   O    doub N N 377 
VAL C   OXT  sing N N 378 
VAL CB  CG1  sing N N 379 
VAL CB  CG2  sing N N 380 
VAL CB  HB   sing N N 381 
VAL CG1 HG11 sing N N 382 
VAL CG1 HG12 sing N N 383 
VAL CG1 HG13 sing N N 384 
VAL CG2 HG21 sing N N 385 
VAL CG2 HG22 sing N N 386 
VAL CG2 HG23 sing N N 387 
VAL OXT HXT  sing N N 388 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                'New Zealand' 
_pdbx_audit_support.grant_number           IF_AgR_Methanol 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9MM2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.023096 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.006357 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016142 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013406 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
NA 
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LYS A 1 32  ? -24.177 28.155  8.518  1.00 23.28 ? 9    LYS A N   1 
ATOM   2    C  CA  . LYS A 1 32  ? -23.794 27.117  7.514  1.00 19.65 ? 9    LYS A CA  1 
ATOM   3    C  C   . LYS A 1 32  ? -22.786 27.660  6.491  1.00 19.29 ? 9    LYS A C   1 
ATOM   4    O  O   . LYS A 1 32  ? -22.836 28.846  6.173  1.00 21.00 ? 9    LYS A O   1 
ATOM   5    C  CB  . LYS A 1 32  ? -24.966 26.460  6.778  1.00 22.04 ? 9    LYS A CB  1 
ATOM   6    C  CG  . LYS A 1 32  ? -25.773 25.527  7.665  1.00 27.13 ? 9    LYS A CG  1 
ATOM   7    C  CD  . LYS A 1 32  ? -25.950 24.123  7.106  1.00 31.30 ? 9    LYS A CD  1 
ATOM   8    C  CE  . LYS A 1 32  ? -26.970 23.349  7.872  1.00 35.03 ? 9    LYS A CE  1 
ATOM   9    N  NZ  . LYS A 1 32  ? -26.422 22.882  9.146  1.00 39.32 ? 9    LYS A NZ  1 
ATOM   10   N  N   . ILE A 1 33  ? -21.859 26.824  6.064  1.00 14.53 ? 10   ILE A N   1 
ATOM   11   C  CA  . ILE A 1 33  ? -20.890 27.117  5.027  1.00 14.34 ? 10   ILE A CA  1 
ATOM   12   C  C   . ILE A 1 33  ? -21.146 26.186  3.842  1.00 13.36 ? 10   ILE A C   1 
ATOM   13   O  O   . ILE A 1 33  ? -21.879 25.187  3.951  1.00 12.99 ? 10   ILE A O   1 
ATOM   14   C  CB  . ILE A 1 33  ? -19.432 27.031  5.525  1.00 14.25 ? 10   ILE A CB  1 
ATOM   15   C  CG1 . ILE A 1 33  ? -19.053 25.547  5.906  1.00 13.46 ? 10   ILE A CG1 1 
ATOM   16   C  CG2 . ILE A 1 33  ? -19.212 27.993  6.694  1.00 17.89 ? 10   ILE A CG2 1 
ATOM   17   C  CD1 . ILE A 1 33  ? -17.569 25.352  6.140  1.00 14.27 ? 10   ILE A CD1 1 
ATOM   18   N  N   . ALA A 1 34  ? -20.542 26.529  2.710  1.00 14.61 ? 11   ALA A N   1 
ATOM   19   C  CA  . ALA A 1 34  ? -20.685 25.721  1.512  1.00 14.84 ? 11   ALA A CA  1 
ATOM   20   C  C   . ALA A 1 34  ? -20.061 24.351  1.722  1.00 12.25 ? 11   ALA A C   1 
ATOM   21   O  O   . ALA A 1 34  ? -19.088 24.223  2.448  1.00 12.96 ? 11   ALA A O   1 
ATOM   22   C  CB  . ALA A 1 34  ? -20.037 26.409  0.320  1.00 17.01 ? 11   ALA A CB  1 
ATOM   23   N  N   . TYR A 1 35  ? -20.555 23.355  1.007  1.00 11.48 ? 12   TYR A N   1 
ATOM   24   C  CA  . TYR A 1 35  ? -19.857 22.101  0.816  1.00 10.88 ? 12   TYR A CA  1 
ATOM   25   C  C   . TYR A 1 35  ? -18.558 22.310  0.067  1.00 11.60 ? 12   TYR A C   1 
ATOM   26   O  O   . TYR A 1 35  ? -18.514 22.971  -0.982 1.00 11.52 ? 12   TYR A O   1 
ATOM   27   C  CB  . TYR A 1 35  ? -20.703 21.165  -0.025 1.00 11.30 ? 12   TYR A CB  1 
ATOM   28   C  CG  . TYR A 1 35  ? -20.074 19.841  -0.399 1.00 11.33 ? 12   TYR A CG  1 
ATOM   29   C  CD1 . TYR A 1 35  ? -19.547 18.975  0.566  1.00 11.27 ? 12   TYR A CD1 1 
ATOM   30   C  CD2 . TYR A 1 35  ? -19.917 19.466  -1.737 1.00 12.72 ? 12   TYR A CD2 1 
ATOM   31   C  CE1 . TYR A 1 35  ? -18.994 17.760  0.206  1.00 10.61 ? 12   TYR A CE1 1 
ATOM   32   C  CE2 . TYR A 1 35  ? -19.330 18.281  -2.116 1.00 12.29 ? 12   TYR A CE2 1 
ATOM   33   C  CZ  . TYR A 1 35  ? -18.850 17.430  -1.127 1.00 10.50 ? 12   TYR A CZ  1 
ATOM   34   O  OH  . TYR A 1 35  ? -18.362 16.227  -1.534 1.00 11.27 ? 12   TYR A OH  1 
ATOM   35   N  N   A SER A 1 36  ? -17.467 21.772  0.638  0.60 10.88 ? 13   SER A N   1 
ATOM   36   N  N   B SER A 1 36  ? -17.531 21.601  0.539  0.40 11.99 ? 13   SER A N   1 
ATOM   37   C  CA  A SER A 1 36  ? -16.209 21.579  -0.057 0.60 9.98  ? 13   SER A CA  1 
ATOM   38   C  CA  B SER A 1 36  ? -16.231 21.553  -0.091 0.40 12.23 ? 13   SER A CA  1 
ATOM   39   C  C   A SER A 1 36  ? -15.906 20.082  -0.024 0.60 9.68  ? 13   SER A C   1 
ATOM   40   C  C   B SER A 1 36  ? -15.780 20.109  -0.015 0.40 11.17 ? 13   SER A C   1 
ATOM   41   O  O   A SER A 1 36  ? -15.853 19.487  1.071  0.60 10.52 ? 13   SER A O   1 
ATOM   42   O  O   B SER A 1 36  ? -15.526 19.625  1.100  0.40 11.22 ? 13   SER A O   1 
ATOM   43   C  CB  A SER A 1 36  ? -15.096 22.375  0.540  0.60 10.26 ? 13   SER A CB  1 
ATOM   44   C  CB  B SER A 1 36  ? -15.243 22.432  0.581  0.40 13.74 ? 13   SER A CB  1 
ATOM   45   O  OG  A SER A 1 36  ? -15.259 23.783  0.344  0.60 10.17 ? 13   SER A OG  1 
ATOM   46   O  OG  B SER A 1 36  ? -14.002 22.403  -0.108 0.40 16.23 ? 13   SER A OG  1 
ATOM   47   N  N   . GLU A 1 37  ? -15.664 19.450  -1.166 1.00 10.41 ? 14   GLU A N   1 
ATOM   48   C  CA  . GLU A 1 37  ? -15.306 18.046  -1.249 1.00 11.12 ? 14   GLU A CA  1 
ATOM   49   C  C   . GLU A 1 37  ? -13.927 17.777  -0.639 1.00 10.74 ? 14   GLU A C   1 
ATOM   50   O  O   . GLU A 1 37  ? -13.698 16.674  -0.090 1.00 10.76 ? 14   GLU A O   1 
ATOM   51   C  CB  . GLU A 1 37  ? -15.369 17.626  -2.715 1.00 12.38 ? 14   GLU A CB  1 
ATOM   52   C  CG  . GLU A 1 37  ? -15.134 16.143  -2.937 1.00 13.82 ? 14   GLU A CG  1 
ATOM   53   C  CD  . GLU A 1 37  ? -15.391 15.618  -4.349 1.00 19.15 ? 14   GLU A CD  1 
ATOM   54   O  OE1 . GLU A 1 37  ? -15.266 14.406  -4.618 1.00 22.38 ? 14   GLU A OE1 1 
ATOM   55   O  OE2 . GLU A 1 37  ? -15.693 16.488  -5.202 1.00 22.72 ? 14   GLU A OE2 1 
ATOM   56   N  N   . ILE A 1 38  ? -13.027 18.738  -0.769 1.00 9.94  ? 15   ILE A N   1 
ATOM   57   C  CA  . ILE A 1 38  ? -11.702 18.615  -0.174 1.00 11.20 ? 15   ILE A CA  1 
ATOM   58   C  C   . ILE A 1 38  ? -11.383 19.863  0.598  1.00 11.27 ? 15   ILE A C   1 
ATOM   59   O  O   . ILE A 1 38  ? -11.574 20.969  0.061  1.00 12.23 ? 15   ILE A O   1 
ATOM   60   C  CB  . ILE A 1 38  ? -10.619 18.407  -1.249 1.00 14.78 ? 15   ILE A CB  1 
ATOM   61   C  CG1 . ILE A 1 38  ? -10.869 17.189  -2.104 1.00 19.71 ? 15   ILE A CG1 1 
ATOM   62   C  CG2 . ILE A 1 38  ? -9.222  18.370  -0.593 1.00 16.15 ? 15   ILE A CG2 1 
ATOM   63   C  CD1 . ILE A 1 38  ? -9.882  17.026  -3.247 1.00 22.66 ? 15   ILE A CD1 1 
ATOM   64   N  N   . ILE A 1 39  ? -10.910 19.762  1.854  1.00 9.89  ? 16   ILE A N   1 
ATOM   65   C  CA  . ILE A 1 39  ? -10.457 20.873  2.636  1.00 10.94 ? 16   ILE A CA  1 
ATOM   66   C  C   . ILE A 1 39  ? -9.054  20.528  3.152  1.00 10.20 ? 16   ILE A C   1 
ATOM   67   O  O   . ILE A 1 39  ? -8.733  19.338  3.343  1.00 11.58 ? 16   ILE A O   1 
ATOM   68   C  CB  . ILE A 1 39  ? -11.414 21.238  3.773  1.00 10.55 ? 16   ILE A CB  1 
ATOM   69   C  CG1 . ILE A 1 39  ? -11.594 20.090  4.778  1.00 10.76 ? 16   ILE A CG1 1 
ATOM   70   C  CG2 . ILE A 1 39  ? -12.763 21.705  3.204  1.00 10.82 ? 16   ILE A CG2 1 
ATOM   71   C  CD1 . ILE A 1 39  ? -12.550 20.389  5.902  1.00 9.93  ? 16   ILE A CD1 1 
ATOM   72   N  N   . THR A 1 40  ? -8.218  21.527  3.329  1.00 9.56  ? 17   THR A N   1 
ATOM   73   C  CA  . THR A 1 40  ? -6.824  21.313  3.665  1.00 9.54  ? 17   THR A CA  1 
ATOM   74   C  C   . THR A 1 40  ? -6.526  21.808  5.062  1.00 10.02 ? 17   THR A C   1 
ATOM   75   O  O   . THR A 1 40  ? -7.097  22.741  5.601  1.00 9.63  ? 17   THR A O   1 
ATOM   76   C  CB  . THR A 1 40  ? -5.939  22.015  2.615  1.00 10.77 ? 17   THR A CB  1 
ATOM   77   O  OG1 . THR A 1 40  ? -6.345  23.393  2.579  1.00 11.67 ? 17   THR A OG1 1 
ATOM   78   C  CG2 . THR A 1 40  ? -6.068  21.333  1.289  1.00 11.62 ? 17   THR A CG2 1 
ATOM   79   N  N   . VAL A 1 41  ? -5.538  21.117  5.676  1.00 9.11  ? 18   VAL A N   1 
ATOM   80   C  CA  . VAL A 1 41  ? -5.031  21.449  6.982  1.00 9.16  ? 18   VAL A CA  1 
ATOM   81   C  C   . VAL A 1 41  ? -3.525  21.657  6.908  1.00 9.37  ? 18   VAL A C   1 
ATOM   82   O  O   . VAL A 1 41  ? -2.832  20.820  6.334  1.00 9.90  ? 18   VAL A O   1 
ATOM   83   C  CB  . VAL A 1 41  ? -5.357  20.367  8.030  1.00 8.68  ? 18   VAL A CB  1 
ATOM   84   C  CG1 . VAL A 1 41  ? -4.590  20.536  9.348  1.00 9.07  ? 18   VAL A CG1 1 
ATOM   85   C  CG2 . VAL A 1 41  ? -6.857  20.304  8.282  1.00 9.00  ? 18   VAL A CG2 1 
ATOM   86   N  N   . GLY A 1 42  ? -3.065  22.735  7.563  1.00 11.13 ? 19   GLY A N   1 
ATOM   87   C  CA  . GLY A 1 42  ? -1.644  23.102  7.549  1.00 12.47 ? 19   GLY A CA  1 
ATOM   88   C  C   . GLY A 1 42  ? -1.468  24.590  7.789  1.00 16.40 ? 19   GLY A C   1 
ATOM   89   O  O   . GLY A 1 42  ? -2.444  25.317  7.872  1.00 16.41 ? 19   GLY A O   1 
ATOM   90   N  N   . THR A 1 43  ? -0.216  25.073  7.872  1.00 17.96 ? 20   THR A N   1 
ATOM   91   C  CA  . THR A 1 43  ? 0.013   26.372  8.499  1.00 19.94 ? 20   THR A CA  1 
ATOM   92   C  C   . THR A 1 43  ? -0.560  27.500  7.634  1.00 22.51 ? 20   THR A C   1 
ATOM   93   O  O   . THR A 1 43  ? -0.946  28.549  8.188  1.00 24.09 ? 20   THR A O   1 
ATOM   94   C  CB  . THR A 1 43  ? 1.500   26.596  8.767  1.00 21.37 ? 20   THR A CB  1 
ATOM   95   O  OG1 . THR A 1 43  ? 2.091   26.495  7.481  1.00 21.39 ? 20   THR A OG1 1 
ATOM   96   C  CG2 . THR A 1 43  ? 2.119   25.577  9.708  1.00 21.44 ? 20   THR A CG2 1 
ATOM   97   N  N   . ASP A 1 44  ? -0.604  27.301  6.312  1.00 18.20 ? 21   ASP A N   1 
ATOM   98   C  CA  . ASP A 1 44  ? -1.179  28.275  5.383  1.00 21.35 ? 21   ASP A CA  1 
ATOM   99   C  C   . ASP A 1 44  ? -2.318  27.660  4.559  1.00 21.38 ? 21   ASP A C   1 
ATOM   100  O  O   . ASP A 1 44  ? -2.555  28.057  3.413  1.00 22.38 ? 21   ASP A O   1 
ATOM   101  C  CB  . ASP A 1 44  ? -0.109  28.739  4.413  1.00 24.01 ? 21   ASP A CB  1 
ATOM   102  C  CG  . ASP A 1 44  ? 0.415   27.598  3.557  1.00 24.89 ? 21   ASP A CG  1 
ATOM   103  O  OD1 . ASP A 1 44  ? 0.208   26.428  3.976  1.00 23.42 ? 21   ASP A OD1 1 
ATOM   104  O  OD2 . ASP A 1 44  ? 1.013   27.842  2.503  1.00 33.32 ? 21   ASP A OD2 1 
ATOM   105  N  N   . LYS A 1 45  ? -3.003  26.628  5.109  1.00 16.47 ? 22   LYS A N   1 
ATOM   106  C  CA  . LYS A 1 45  ? -4.056  25.933  4.375  1.00 14.89 ? 22   LYS A CA  1 
ATOM   107  C  C   . LYS A 1 45  ? -5.427  26.464  4.814  1.00 13.95 ? 22   LYS A C   1 
ATOM   108  O  O   . LYS A 1 45  ? -5.522  27.443  5.528  1.00 14.85 ? 22   LYS A O   1 
ATOM   109  C  CB  . LYS A 1 45  ? -3.859  24.417  4.627  1.00 14.91 ? 22   LYS A CB  1 
ATOM   110  C  CG  . LYS A 1 45  ? -2.527  23.865  4.100  1.00 14.57 ? 22   LYS A CG  1 
ATOM   111  C  CD  . LYS A 1 45  ? -2.302  24.116  2.609  1.00 15.44 ? 22   LYS A CD  1 
ATOM   112  C  CE  . LYS A 1 45  ? -1.103  23.387  2.080  1.00 15.56 ? 22   LYS A CE  1 
ATOM   113  N  NZ  . LYS A 1 45  ? 0.102   23.763  2.841  1.00 16.01 ? 22   LYS A NZ  1 
ATOM   114  N  N   . ASP A 1 46  ? -6.507  25.740  4.450  1.00 12.16 ? 23   ASP A N   1 
ATOM   115  C  CA  . ASP A 1 46  ? -7.859  26.168  4.781  1.00 12.78 ? 23   ASP A CA  1 
ATOM   116  C  C   . ASP A 1 46  ? -8.016  26.308  6.280  1.00 12.36 ? 23   ASP A C   1 
ATOM   117  O  O   . ASP A 1 46  ? -8.595  27.265  6.789  1.00 14.59 ? 23   ASP A O   1 
ATOM   118  C  CB  . ASP A 1 46  ? -8.901  25.228  4.216  1.00 12.34 ? 23   ASP A CB  1 
ATOM   119  C  CG  . ASP A 1 46  ? -8.992  25.068  2.712  1.00 13.72 ? 23   ASP A CG  1 
ATOM   120  O  OD1 . ASP A 1 46  ? -8.528  26.043  1.987  1.00 14.81 ? 23   ASP A OD1 1 
ATOM   121  O  OD2 . ASP A 1 46  ? -9.507  24.046  2.238  1.00 12.98 ? 23   ASP A OD2 1 
ATOM   122  N  N   . TYR A 1 47  ? -7.493  25.305  6.994  1.00 11.70 ? 24   TYR A N   1 
ATOM   123  C  CA  . TYR A 1 47  ? -7.647  25.230  8.463  1.00 12.74 ? 24   TYR A CA  1 
ATOM   124  C  C   . TYR A 1 47  ? -6.296  24.911  9.095  1.00 12.44 ? 24   TYR A C   1 
ATOM   125  O  O   . TYR A 1 47  ? -5.520  24.200  8.482  1.00 12.59 ? 24   TYR A O   1 
ATOM   126  C  CB  . TYR A 1 47  ? -8.666  24.146  8.843  1.00 12.09 ? 24   TYR A CB  1 
ATOM   127  C  CG  . TYR A 1 47  ? -10.033 24.484  8.266  1.00 11.34 ? 24   TYR A CG  1 
ATOM   128  C  CD1 . TYR A 1 47  ? -10.823 25.452  8.866  1.00 12.14 ? 24   TYR A CD1 1 
ATOM   129  C  CD2 . TYR A 1 47  ? -10.489 23.907  7.089  1.00 11.05 ? 24   TYR A CD2 1 
ATOM   130  C  CE1 . TYR A 1 47  ? -12.044 25.817  8.328  1.00 12.07 ? 24   TYR A CE1 1 
ATOM   131  C  CE2 . TYR A 1 47  ? -11.709 24.266  6.540  1.00 11.80 ? 24   TYR A CE2 1 
ATOM   132  C  CZ  . TYR A 1 47  ? -12.484 25.227  7.161  1.00 11.81 ? 24   TYR A CZ  1 
ATOM   133  O  OH  . TYR A 1 47  ? -13.685 25.606  6.638  1.00 13.93 ? 24   TYR A OH  1 
ATOM   134  N  N   . LYS A 1 48  ? -6.076  25.392  10.316 1.00 13.04 ? 25   LYS A N   1 
ATOM   135  C  CA  . LYS A 1 48  ? -4.758  25.249  10.921 1.00 14.48 ? 25   LYS A CA  1 
ATOM   136  C  C   . LYS A 1 48  ? -4.657  24.000  11.777 1.00 13.98 ? 25   LYS A C   1 
ATOM   137  O  O   . LYS A 1 48  ? -3.558  23.518  11.997 1.00 14.41 ? 25   LYS A O   1 
ATOM   138  C  CB  . LYS A 1 48  ? -4.440  26.503  11.724 1.00 17.71 ? 25   LYS A CB  1 
ATOM   139  C  CG  . LYS A 1 48  ? -3.935  27.654  10.831 1.00 25.36 ? 25   LYS A CG  1 
ATOM   140  C  CD  . LYS A 1 48  ? -4.510  27.748  9.416  1.00 29.67 ? 25   LYS A CD  1 
ATOM   141  C  CE  . LYS A 1 48  ? -4.085  29.025  8.743  1.00 32.69 ? 25   LYS A CE  1 
ATOM   142  N  NZ  . LYS A 1 48  ? -4.440  29.091  7.330  1.00 35.45 ? 25   LYS A NZ  1 
ATOM   143  N  N   . THR A 1 49  ? -5.793  23.467  12.195 1.00 11.09 ? 26   THR A N   1 
ATOM   144  C  CA  . THR A 1 49  ? -5.860  22.260  13.014 1.00 10.23 ? 26   THR A CA  1 
ATOM   145  C  C   . THR A 1 49  ? -6.868  21.305  12.370 1.00 9.72  ? 26   THR A C   1 
ATOM   146  O  O   . THR A 1 49  ? -7.813  21.720  11.659 1.00 9.65  ? 26   THR A O   1 
ATOM   147  C  CB  . THR A 1 49  ? -6.253  22.568  14.458 1.00 10.46 ? 26   THR A CB  1 
ATOM   148  O  OG1 . THR A 1 49  ? -7.634  22.928  14.516 1.00 10.40 ? 26   THR A OG1 1 
ATOM   149  C  CG2 . THR A 1 49  ? -5.391  23.658  15.091 1.00 11.17 ? 26   THR A CG2 1 
ATOM   150  N  N   . ILE A 1 50  ? -6.721  20.013  12.671 1.00 8.58  ? 27   ILE A N   1 
ATOM   151  C  CA  . ILE A 1 50  ? -7.661  19.030  12.168 1.00 8.34  ? 27   ILE A CA  1 
ATOM   152  C  C   . ILE A 1 50  ? -9.025  19.245  12.823 1.00 8.53  ? 27   ILE A C   1 
ATOM   153  O  O   . ILE A 1 50  ? -10.066 19.094  12.183 1.00 9.08  ? 27   ILE A O   1 
ATOM   154  C  CB  . ILE A 1 50  ? -7.119  17.602  12.383 1.00 8.46  ? 27   ILE A CB  1 
ATOM   155  C  CG1 . ILE A 1 50  ? -5.739  17.388  11.762 1.00 8.45  ? 27   ILE A CG1 1 
ATOM   156  C  CG2 . ILE A 1 50  ? -8.100  16.566  11.847 1.00 8.93  ? 27   ILE A CG2 1 
ATOM   157  C  CD1 . ILE A 1 50  ? -5.015  16.146  12.242 1.00 8.04  ? 27   ILE A CD1 1 
ATOM   158  N  N   A SER A 1 51  ? -9.045  19.553  14.127 0.70 9.29  ? 28   SER A N   1 
ATOM   159  N  N   B SER A 1 51  ? -9.038  19.634  14.101 0.30 8.10  ? 28   SER A N   1 
ATOM   160  C  CA  A SER A 1 51  ? -10.256 19.902  14.863 0.70 10.18 ? 28   SER A CA  1 
ATOM   161  C  CA  B SER A 1 51  ? -10.279 19.844  14.834 0.30 7.84  ? 28   SER A CA  1 
ATOM   162  C  C   A SER A 1 51  ? -11.073 20.960  14.124 0.70 9.89  ? 28   SER A C   1 
ATOM   163  C  C   B SER A 1 51  ? -11.084 21.017  14.266 0.30 8.56  ? 28   SER A C   1 
ATOM   164  O  O   A SER A 1 51  ? -12.278 20.851  13.932 0.70 8.76  ? 28   SER A O   1 
ATOM   165  O  O   B SER A 1 51  ? -12.317 21.004  14.319 0.30 8.15  ? 28   SER A O   1 
ATOM   166  C  CB  A SER A 1 51  ? -9.901  20.385  16.263 0.70 12.58 ? 28   SER A CB  1 
ATOM   167  C  CB  B SER A 1 51  ? -9.972  20.001  16.304 0.30 7.42  ? 28   SER A CB  1 
ATOM   168  O  OG  A SER A 1 51  ? -9.329  19.333  17.013 0.70 18.30 ? 28   SER A OG  1 
ATOM   169  O  OG  B SER A 1 51  ? -11.079 20.453  17.067 0.30 7.06  ? 28   SER A OG  1 
ATOM   170  N  N   . ASP A 1 52  ? -10.379 22.025  13.714 1.00 9.24  ? 29   ASP A N   1 
ATOM   171  C  CA  . ASP A 1 52  ? -11.050 23.145  13.050 1.00 10.19 ? 29   ASP A CA  1 
ATOM   172  C  C   . ASP A 1 52  ? -11.695 22.653  11.773 1.00 9.99  ? 29   ASP A C   1 
ATOM   173  O  O   . ASP A 1 52  ? -12.835 23.068  11.435 1.00 10.96 ? 29   ASP A O   1 
ATOM   174  C  CB  . ASP A 1 52  ? -10.134 24.332  12.785 1.00 11.12 ? 29   ASP A CB  1 
ATOM   175  C  CG  . ASP A 1 52  ? -9.783  25.180  13.993 1.00 13.63 ? 29   ASP A CG  1 
ATOM   176  O  OD1 . ASP A 1 52  ? -10.398 24.994  15.023 1.00 16.05 ? 29   ASP A OD1 1 
ATOM   177  O  OD2 . ASP A 1 52  ? -8.863  26.010  13.814 1.00 18.03 ? 29   ASP A OD2 1 
ATOM   178  N  N   . ALA A 1 53  ? -11.012 21.780  11.030 1.00 8.91  ? 30   ALA A N   1 
ATOM   179  C  CA  . ALA A 1 53  ? -11.549 21.246  9.789  1.00 8.84  ? 30   ALA A CA  1 
ATOM   180  C  C   . ALA A 1 53  ? -12.782 20.393  10.041 1.00 8.98  ? 30   ALA A C   1 
ATOM   181  O  O   . ALA A 1 53  ? -13.779 20.480  9.309  1.00 9.56  ? 30   ALA A O   1 
ATOM   182  C  CB  . ALA A 1 53  ? -10.475 20.501  9.045  1.00 8.78  ? 30   ALA A CB  1 
ATOM   183  N  N   . ILE A 1 54  ? -12.738 19.517  11.054 1.00 8.45  ? 31   ILE A N   1 
ATOM   184  C  CA  . ILE A 1 54  ? -13.920 18.723  11.359 1.00 9.05  ? 31   ILE A CA  1 
ATOM   185  C  C   . ILE A 1 54  ? -15.089 19.609  11.794 1.00 8.48  ? 31   ILE A C   1 
ATOM   186  O  O   . ILE A 1 54  ? -16.237 19.367  11.400 1.00 9.25  ? 31   ILE A O   1 
ATOM   187  C  CB  . ILE A 1 54  ? -13.616 17.632  12.402 1.00 9.58  ? 31   ILE A CB  1 
ATOM   188  C  CG1 . ILE A 1 54  ? -12.629 16.653  11.847 1.00 10.10 ? 31   ILE A CG1 1 
ATOM   189  C  CG2 . ILE A 1 54  ? -14.874 16.932  12.900 1.00 11.47 ? 31   ILE A CG2 1 
ATOM   190  C  CD1 . ILE A 1 54  ? -12.107 15.644  12.837 1.00 11.71 ? 31   ILE A CD1 1 
ATOM   191  N  N   . GLU A 1 55  ? -14.814 20.625  12.591 1.00 8.35  ? 32   GLU A N   1 
ATOM   192  C  CA  . GLU A 1 55  ? -15.873 21.538  13.009 1.00 8.97  ? 32   GLU A CA  1 
ATOM   193  C  C   . GLU A 1 55  ? -16.477 22.241  11.781 1.00 9.62  ? 32   GLU A C   1 
ATOM   194  O  O   . GLU A 1 55  ? -17.699 22.429  11.728 1.00 10.37 ? 32   GLU A O   1 
ATOM   195  C  CB  . GLU A 1 55  ? -15.313 22.531  14.027 1.00 11.23 ? 32   GLU A CB  1 
ATOM   196  C  CG  . GLU A 1 55  ? -16.305 23.576  14.530 1.00 12.11 ? 32   GLU A CG  1 
ATOM   197  C  CD  . GLU A 1 55  ? -17.474 23.049  15.318 1.00 15.61 ? 32   GLU A CD  1 
ATOM   198  O  OE1 . GLU A 1 55  ? -18.402 23.824  15.624 1.00 18.18 ? 32   GLU A OE1 1 
ATOM   199  O  OE2 . GLU A 1 55  ? -17.497 21.874  15.733 1.00 14.52 ? 32   GLU A OE2 1 
ATOM   200  N  N   . ALA A 1 56  ? -15.665 22.581  10.804 1.00 9.36  ? 33   ALA A N   1 
ATOM   201  C  CA  . ALA A 1 56  ? -16.190 23.193  9.592  1.00 10.69 ? 33   ALA A CA  1 
ATOM   202  C  C   . ALA A 1 56  ? -17.129 22.215  8.902  1.00 10.47 ? 33   ALA A C   1 
ATOM   203  O  O   . ALA A 1 56  ? -18.216 22.565  8.419  1.00 10.87 ? 33   ALA A O   1 
ATOM   204  C  CB  . ALA A 1 56  ? -15.084 23.600  8.671  1.00 11.54 ? 33   ALA A CB  1 
ATOM   205  N  N   . ILE A 1 57  ? -16.762 20.929  8.816  1.00 9.34  ? 34   ILE A N   1 
ATOM   206  C  CA  . ILE A 1 57  ? -17.616 19.937  8.185  1.00 8.77  ? 34   ILE A CA  1 
ATOM   207  C  C   . ILE A 1 57  ? -18.950 19.887  8.914  1.00 9.09  ? 34   ILE A C   1 
ATOM   208  O  O   . ILE A 1 57  ? -20.019 19.774  8.288  1.00 8.88  ? 34   ILE A O   1 
ATOM   209  C  CB  . ILE A 1 57  ? -16.957 18.539  8.146  1.00 8.96  ? 34   ILE A CB  1 
ATOM   210  C  CG1 . ILE A 1 57  ? -15.727 18.603  7.283  1.00 9.20  ? 34   ILE A CG1 1 
ATOM   211  C  CG2 . ILE A 1 57  ? -17.945 17.475  7.675  1.00 9.12  ? 34   ILE A CG2 1 
ATOM   212  C  CD1 . ILE A 1 57  ? -14.871 17.345  7.348  1.00 10.04 ? 34   ILE A CD1 1 
ATOM   213  N  N   . ARG A 1 58  ? -18.995 19.972  10.239 1.00 9.53  ? 35   ARG A N   1 
ATOM   214  C  CA  . ARG A 1 58  ? -20.281 19.986  10.998 1.00 9.70  ? 35   ARG A CA  1 
ATOM   215  C  C   . ARG A 1 58  ? -21.204 21.142  10.542 1.00 11.22 ? 35   ARG A C   1 
ATOM   216  O  O   . ARG A 1 58  ? -22.404 21.019  10.708 1.00 13.17 ? 35   ARG A O   1 
ATOM   217  C  CB  . ARG A 1 58  ? -20.036 20.121  12.507 1.00 9.61  ? 35   ARG A CB  1 
ATOM   218  C  CG  . ARG A 1 58  ? -19.282 18.933  13.093 1.00 10.12 ? 35   ARG A CG  1 
ATOM   219  C  CD  . ARG A 1 58  ? -19.163 19.076  14.597 1.00 10.97 ? 35   ARG A CD  1 
ATOM   220  N  NE  . ARG A 1 58  ? -18.427 17.957  15.196 1.00 10.99 ? 35   ARG A NE  1 
ATOM   221  C  CZ  . ARG A 1 58  ? -17.164 18.013  15.576 1.00 10.61 ? 35   ARG A CZ  1 
ATOM   222  N  NH1 . ARG A 1 58  ? -16.532 19.167  15.626 1.00 11.81 ? 35   ARG A NH1 1 
ATOM   223  N  NH2 . ARG A 1 58  ? -16.532 16.908  15.923 1.00 11.21 ? 35   ARG A NH2 1 
ATOM   224  N  N   . HIS A 1 59  ? -20.634 22.194  9.989  1.00 10.38 ? 36   HIS A N   1 
ATOM   225  C  CA  . HIS A 1 59  ? -21.391 23.367  9.542  1.00 12.13 ? 36   HIS A CA  1 
ATOM   226  C  C   . HIS A 1 59  ? -21.631 23.348  8.047  1.00 11.31 ? 36   HIS A C   1 
ATOM   227  O  O   . HIS A 1 59  ? -22.227 24.312  7.575  1.00 12.19 ? 36   HIS A O   1 
ATOM   228  C  CB  . HIS A 1 59  ? -20.666 24.670  9.897  1.00 14.49 ? 36   HIS A CB  1 
ATOM   229  C  CG  . HIS A 1 59  ? -20.610 24.903  11.349 1.00 16.19 ? 36   HIS A CG  1 
ATOM   230  N  ND1 . HIS A 1 59  ? -21.550 25.579  12.118 1.00 22.18 ? 36   HIS A ND1 1 
ATOM   231  C  CD2 . HIS A 1 59  ? -19.660 24.498  12.204 1.00 16.45 ? 36   HIS A CD2 1 
ATOM   232  C  CE1 . HIS A 1 59  ? -21.139 25.594  13.389 1.00 21.38 ? 36   HIS A CE1 1 
ATOM   233  N  NE2 . HIS A 1 59  ? -20.015 24.895  13.459 1.00 21.52 ? 36   HIS A NE2 1 
ATOM   234  N  N   . MET A 1 60  ? -21.241 22.349  7.294  1.00 10.14 ? 37   MET A N   1 
ATOM   235  C  CA  . MET A 1 60  ? -21.392 22.405  5.849  1.00 10.60 ? 37   MET A CA  1 
ATOM   236  C  C   . MET A 1 60  ? -22.834 22.115  5.470  1.00 10.25 ? 37   MET A C   1 
ATOM   237  O  O   . MET A 1 60  ? -23.483 21.240  5.990  1.00 11.02 ? 37   MET A O   1 
ATOM   238  C  CB  . MET A 1 60  ? -20.482 21.421  5.111  1.00 10.21 ? 37   MET A CB  1 
ATOM   239  C  CG  . MET A 1 60  ? -19.058 21.845  5.059  1.00 10.85 ? 37   MET A CG  1 
ATOM   240  S  SD  . MET A 1 60  ? -18.094 20.597  4.182  1.00 10.80 ? 37   MET A SD  1 
ATOM   241  C  CE  . MET A 1 60  ? -16.487 21.395  4.245  1.00 12.22 ? 37   MET A CE  1 
ATOM   242  N  N   . GLU A 1 61  ? -23.277 22.845  4.428  1.00 10.53 ? 38   GLU A N   1 
ATOM   243  C  CA  . GLU A 1 61  ? -24.486 22.492  3.725  1.00 10.72 ? 38   GLU A CA  1 
ATOM   244  C  C   . GLU A 1 61  ? -24.170 21.404  2.730  1.00 10.26 ? 38   GLU A C   1 
ATOM   245  O  O   . GLU A 1 61  ? -23.863 21.640  1.559  1.00 12.79 ? 38   GLU A O   1 
ATOM   246  C  CB  . GLU A 1 61  ? -24.969 23.746  2.994  1.00 11.67 ? 38   GLU A CB  1 
ATOM   247  C  CG  . GLU A 1 61  ? -26.310 23.566  2.279  1.00 12.06 ? 38   GLU A CG  1 
ATOM   248  C  CD  . GLU A 1 61  ? -27.378 22.914  3.146  1.00 12.95 ? 38   GLU A CD  1 
ATOM   249  O  OE1 . GLU A 1 61  ? -27.937 23.661  4.028  1.00 17.16 ? 38   GLU A OE1 1 
ATOM   250  O  OE2 . GLU A 1 61  ? -27.645 21.714  3.092  1.00 12.50 ? 38   GLU A OE2 1 
ATOM   251  N  N   . ARG A 1 62  ? -24.251 20.179  3.234  1.00 9.34  ? 39   ARG A N   1 
ATOM   252  C  CA  . ARG A 1 62  ? -24.027 18.997  2.384  1.00 10.21 ? 39   ARG A CA  1 
ATOM   253  C  C   . ARG A 1 62  ? -24.970 17.891  2.820  1.00 9.84  ? 39   ARG A C   1 
ATOM   254  O  O   . ARG A 1 62  ? -25.539 17.971  3.898  1.00 11.43 ? 39   ARG A O   1 
ATOM   255  C  CB  . ARG A 1 62  ? -22.611 18.427  2.551  1.00 10.99 ? 39   ARG A CB  1 
ATOM   256  C  CG  . ARG A 1 62  ? -22.324 17.783  3.900  1.00 11.27 ? 39   ARG A CG  1 
ATOM   257  C  CD  . ARG A 1 62  ? -21.053 16.954  3.901  1.00 12.03 ? 39   ARG A CD  1 
ATOM   258  N  NE  . ARG A 1 62  ? -20.878 16.408  5.250  1.00 11.33 ? 39   ARG A NE  1 
ATOM   259  C  CZ  . ARG A 1 62  ? -20.357 15.230  5.574  1.00 10.07 ? 39   ARG A CZ  1 
ATOM   260  N  NH1 . ARG A 1 62  ? -19.765 14.470  4.673  1.00 9.95  ? 39   ARG A NH1 1 
ATOM   261  N  NH2 . ARG A 1 62  ? -20.418 14.827  6.828  1.00 10.53 ? 39   ARG A NH2 1 
ATOM   262  N  N   . ASP A 1 63  ? -25.230 16.961  1.910  1.00 9.64  ? 40   ASP A N   1 
ATOM   263  C  CA  . ASP A 1 63  ? -25.912 15.743  2.273  1.00 11.14 ? 40   ASP A CA  1 
ATOM   264  C  C   . ASP A 1 63  ? -24.854 14.880  2.959  1.00 11.81 ? 40   ASP A C   1 
ATOM   265  O  O   . ASP A 1 63  ? -23.699 14.940  2.613  1.00 12.45 ? 40   ASP A O   1 
ATOM   266  C  CB  . ASP A 1 63  ? -26.495 15.058  1.047  1.00 12.96 ? 40   ASP A CB  1 
ATOM   267  C  CG  . ASP A 1 63  ? -27.379 13.894  1.450  1.00 14.29 ? 40   ASP A CG  1 
ATOM   268  O  OD1 . ASP A 1 63  ? -28.481 14.161  1.975  1.00 16.14 ? 40   ASP A OD1 1 
ATOM   269  O  OD2 . ASP A 1 63  ? -26.915 12.740  1.324  1.00 15.87 ? 40   ASP A OD2 1 
ATOM   270  N  N   . ASP A 1 64  ? -25.266 14.027  3.869  1.00 13.91 ? 41   ASP A N   1 
ATOM   271  C  CA  . ASP A 1 64  ? -24.329 13.161  4.574  1.00 15.20 ? 41   ASP A CA  1 
ATOM   272  C  C   . ASP A 1 64  ? -23.640 12.205  3.606  1.00 14.54 ? 41   ASP A C   1 
ATOM   273  O  O   . ASP A 1 64  ? -22.551 11.722  3.972  1.00 15.06 ? 41   ASP A O   1 
ATOM   274  C  CB  . ASP A 1 64  ? -25.076 12.398  5.665  1.00 17.28 ? 41   ASP A CB  1 
ATOM   275  C  CG  . ASP A 1 64  ? -25.468 13.233  6.875  1.00 23.36 ? 41   ASP A CG  1 
ATOM   276  O  OD1 . ASP A 1 64  ? -24.830 14.282  7.077  1.00 29.40 ? 41   ASP A OD1 1 
ATOM   277  O  OD2 . ASP A 1 64  ? -26.452 12.844  7.572  1.00 32.28 ? 41   ASP A OD2 1 
ATOM   278  N  N   . SER A 1 65  ? -24.211 11.958  2.401  1.00 12.22 ? 42   SER A N   1 
ATOM   279  C  CA  . SER A 1 65  ? -23.624 11.076  1.400  1.00 12.50 ? 42   SER A CA  1 
ATOM   280  C  C   . SER A 1 65  ? -22.472 11.726  0.662  1.00 11.08 ? 42   SER A C   1 
ATOM   281  O  O   . SER A 1 65  ? -21.713 11.013  0.012  1.00 13.19 ? 42   SER A O   1 
ATOM   282  C  CB  . SER A 1 65  ? -24.596 10.503  0.425  1.00 12.91 ? 42   SER A CB  1 
ATOM   283  O  OG  . SER A 1 65  ? -25.115 11.549  -0.380 1.00 14.68 ? 42   SER A OG  1 
ATOM   284  N  N   . GLN A 1 66  ? -22.356 13.038  0.740  1.00 10.25 ? 43   GLN A N   1 
ATOM   285  C  CA  . GLN A 1 66  ? -21.283 13.752  0.014  1.00 10.18 ? 43   GLN A CA  1 
ATOM   286  C  C   . GLN A 1 66  ? -20.014 13.738  0.868  1.00 10.45 ? 43   GLN A C   1 
ATOM   287  O  O   . GLN A 1 66  ? -19.973 14.397  1.897  1.00 11.82 ? 43   GLN A O   1 
ATOM   288  C  CB  . GLN A 1 66  ? -21.663 15.205  -0.237 1.00 10.40 ? 43   GLN A CB  1 
ATOM   289  C  CG  . GLN A 1 66  ? -22.784 15.360  -1.256 1.00 10.64 ? 43   GLN A CG  1 
ATOM   290  C  CD  . GLN A 1 66  ? -23.214 16.799  -1.404 1.00 11.81 ? 43   GLN A CD  1 
ATOM   291  O  OE1 . GLN A 1 66  ? -23.826 17.376  -0.506 1.00 11.02 ? 43   GLN A OE1 1 
ATOM   292  N  NE2 . GLN A 1 66  ? -22.868 17.396  -2.533 1.00 14.20 ? 43   GLN A NE2 1 
ATOM   293  N  N   . ARG A 1 67  ? -19.020 13.021  0.382  1.00 9.15  ? 44   ARG A N   1 
ATOM   294  C  CA  . ARG A 1 67  ? -17.785 12.890  1.188  1.00 8.77  ? 44   ARG A CA  1 
ATOM   295  C  C   . ARG A 1 67  ? -16.986 14.189  1.292  1.00 8.83  ? 44   ARG A C   1 
ATOM   296  O  O   . ARG A 1 67  ? -16.966 14.979  0.365  1.00 9.41  ? 44   ARG A O   1 
ATOM   297  C  CB  . ARG A 1 67  ? -16.915 11.787  0.580  1.00 9.59  ? 44   ARG A CB  1 
ATOM   298  C  CG  . ARG A 1 67  ? -15.615 11.570  1.345  1.00 10.52 ? 44   ARG A CG  1 
ATOM   299  C  CD  . ARG A 1 67  ? -14.872 10.305  0.961  1.00 10.22 ? 44   ARG A CD  1 
ATOM   300  N  NE  . ARG A 1 67  ? -15.631 9.103   1.314  1.00 9.63  ? 44   ARG A NE  1 
ATOM   301  C  CZ  . ARG A 1 67  ? -15.770 8.613   2.535  1.00 8.84  ? 44   ARG A CZ  1 
ATOM   302  N  NH1 . ARG A 1 67  ? -14.959 8.992   3.504  1.00 8.64  ? 44   ARG A NH1 1 
ATOM   303  N  NH2 . ARG A 1 67  ? -16.731 7.751   2.777  1.00 10.21 ? 44   ARG A NH2 1 
ATOM   304  N  N   . VAL A 1 68  ? -16.373 14.369  2.446  1.00 8.59  ? 45   VAL A N   1 
ATOM   305  C  CA  . VAL A 1 68  ? -15.400 15.475  2.612  1.00 8.34  ? 45   VAL A CA  1 
ATOM   306  C  C   . VAL A 1 68  ? -14.057 14.804  2.929  1.00 9.45  ? 45   VAL A C   1 
ATOM   307  O  O   . VAL A 1 68  ? -14.021 14.014  3.875  1.00 9.51  ? 45   VAL A O   1 
ATOM   308  C  CB  . VAL A 1 68  ? -15.750 16.504  3.702  1.00 9.00  ? 45   VAL A CB  1 
ATOM   309  C  CG1 . VAL A 1 68  ? -14.673 17.576  3.797  1.00 9.41  ? 45   VAL A CG1 1 
ATOM   310  C  CG2 . VAL A 1 68  ? -17.108 17.144  3.437  1.00 8.60  ? 45   VAL A CG2 1 
ATOM   311  N  N   . THR A 1 69  ? -13.026 15.140  2.194  1.00 8.85  ? 46   THR A N   1 
ATOM   312  C  CA  . THR A 1 69  ? -11.668 14.664  2.461  1.00 9.07  ? 46   THR A CA  1 
ATOM   313  C  C   . THR A 1 69  ? -10.899 15.791  3.100  1.00 9.48  ? 46   THR A C   1 
ATOM   314  O  O   . THR A 1 69  ? -10.816 16.877  2.522  1.00 10.47 ? 46   THR A O   1 
ATOM   315  C  CB  . THR A 1 69  ? -11.008 14.237  1.149  1.00 9.41  ? 46   THR A CB  1 
ATOM   316  O  OG1 . THR A 1 69  ? -11.646 13.076  0.669  1.00 11.15 ? 46   THR A OG1 1 
ATOM   317  C  CG2 . THR A 1 69  ? -9.542  13.854  1.363  1.00 10.91 ? 46   THR A CG2 1 
ATOM   318  N  N   . ILE A 1 70  ? -10.295 15.569  4.271  1.00 8.96  ? 47   ILE A N   1 
ATOM   319  C  CA  . ILE A 1 70  ? -9.409  16.491  4.943  1.00 9.17  ? 47   ILE A CA  1 
ATOM   320  C  C   . ILE A 1 70  ? -7.988  16.075  4.550  1.00 9.27  ? 47   ILE A C   1 
ATOM   321  O  O   . ILE A 1 70  ? -7.506  15.011  4.988  1.00 9.13  ? 47   ILE A O   1 
ATOM   322  C  CB  . ILE A 1 70  ? -9.603  16.520  6.461  1.00 8.83  ? 47   ILE A CB  1 
ATOM   323  C  CG1 . ILE A 1 70  ? -11.068 16.715  6.823  1.00 9.29  ? 47   ILE A CG1 1 
ATOM   324  C  CG2 . ILE A 1 70  ? -8.703  17.546  7.119  1.00 9.93  ? 47   ILE A CG2 1 
ATOM   325  C  CD1 . ILE A 1 70  ? -11.354 16.776  8.308  1.00 9.74  ? 47   ILE A CD1 1 
ATOM   326  N  N   . LYS A 1 71  ? -7.312  16.863  3.715  1.00 9.51  ? 48   LYS A N   1 
ATOM   327  C  CA  . LYS A 1 71  ? -5.981  16.607  3.218  1.00 9.28  ? 48   LYS A CA  1 
ATOM   328  C  C   . LYS A 1 71  ? -5.023  17.371  4.111  1.00 8.94  ? 48   LYS A C   1 
ATOM   329  O  O   . LYS A 1 71  ? -5.008  18.602  4.158  1.00 8.89  ? 48   LYS A O   1 
ATOM   330  C  CB  . LYS A 1 71  ? -5.916  17.063  1.757  1.00 11.87 ? 48   LYS A CB  1 
ATOM   331  C  CG  . LYS A 1 71  ? -4.645  16.759  1.122  1.00 14.34 ? 48   LYS A CG  1 
ATOM   332  C  CD  . LYS A 1 71  ? -4.785  17.038  -0.388 1.00 20.47 ? 48   LYS A CD  1 
ATOM   333  C  CE  . LYS A 1 71  ? -3.536  16.906  -1.146 1.00 23.97 ? 48   LYS A CE  1 
ATOM   334  N  NZ  . LYS A 1 71  ? -3.915  17.099  -2.565 1.00 25.83 ? 48   LYS A NZ  1 
ATOM   335  N  N   . ILE A 1 72  ? -4.273  16.598  4.918  1.00 8.32  ? 49   ILE A N   1 
ATOM   336  C  CA  . ILE A 1 72  ? -3.484  17.123  6.029  1.00 7.62  ? 49   ILE A CA  1 
ATOM   337  C  C   . ILE A 1 72  ? -2.010  17.183  5.671  1.00 7.83  ? 49   ILE A C   1 
ATOM   338  O  O   . ILE A 1 72  ? -1.428  16.171  5.345  1.00 8.03  ? 49   ILE A O   1 
ATOM   339  C  CB  . ILE A 1 72  ? -3.719  16.272  7.302  1.00 7.55  ? 49   ILE A CB  1 
ATOM   340  C  CG1 . ILE A 1 72  ? -5.215  16.139  7.598  1.00 7.31  ? 49   ILE A CG1 1 
ATOM   341  C  CG2 . ILE A 1 72  ? -2.982  16.827  8.486  1.00 8.08  ? 49   ILE A CG2 1 
ATOM   342  C  CD1 . ILE A 1 72  ? -5.538  15.004  8.577  1.00 8.03  ? 49   ILE A CD1 1 
ATOM   343  N  N   . ASP A 1 73  ? -1.465  18.368  5.839  1.00 8.01  ? 50   ASP A N   1 
ATOM   344  C  CA  . ASP A 1 73  ? -0.009  18.507  5.630  1.00 8.55  ? 50   ASP A CA  1 
ATOM   345  C  C   . ASP A 1 73  ? 0.769   17.672  6.652  1.00 8.28  ? 50   ASP A C   1 
ATOM   346  O  O   . ASP A 1 73  ? 0.388   17.641  7.825  1.00 8.23  ? 50   ASP A O   1 
ATOM   347  C  CB  . ASP A 1 73  ? 0.462   19.927  5.896  1.00 9.84  ? 50   ASP A CB  1 
ATOM   348  C  CG  . ASP A 1 73  ? 0.140   20.939  4.809  1.00 10.86 ? 50   ASP A CG  1 
ATOM   349  O  OD1 . ASP A 1 73  ? -0.342  20.510  3.757  1.00 11.70 ? 50   ASP A OD1 1 
ATOM   350  O  OD2 . ASP A 1 73  ? 0.386   22.131  5.047  1.00 12.23 ? 50   ASP A OD2 1 
ATOM   351  N  N   . PRO A 1 74  ? 1.858   16.985  6.250  1.00 8.10  ? 51   PRO A N   1 
ATOM   352  C  CA  . PRO A 1 74  ? 2.744   16.348  7.230  1.00 7.89  ? 51   PRO A CA  1 
ATOM   353  C  C   . PRO A 1 74  ? 3.034   17.279  8.376  1.00 8.02  ? 51   PRO A C   1 
ATOM   354  O  O   . PRO A 1 74  ? 3.263   18.491  8.239  1.00 9.05  ? 51   PRO A O   1 
ATOM   355  C  CB  . PRO A 1 74  ? 3.987   16.045  6.385  1.00 8.38  ? 51   PRO A CB  1 
ATOM   356  C  CG  . PRO A 1 74  ? 3.415   15.719  5.043  1.00 8.72  ? 51   PRO A CG  1 
ATOM   357  C  CD  . PRO A 1 74  ? 2.278   16.739  4.853  1.00 8.53  ? 51   PRO A CD  1 
ATOM   358  N  N   . GLY A 1 75  ? 2.990   16.696  9.591  1.00 7.65  ? 52   GLY A N   1 
ATOM   359  C  CA  . GLY A 1 75  ? 3.189   17.446  10.799 1.00 7.87  ? 52   GLY A CA  1 
ATOM   360  C  C   . GLY A 1 75  ? 2.749   16.604  11.996 1.00 7.39  ? 52   GLY A C   1 
ATOM   361  O  O   . GLY A 1 75  ? 2.256   15.488  11.839 1.00 7.82  ? 52   GLY A O   1 
ATOM   362  N  N   . ASN A 1 76  ? 2.934   17.175  13.161 1.00 7.47  ? 53   ASN A N   1 
ATOM   363  C  CA  . ASN A 1 76  ? 2.590   16.559  14.434 1.00 7.49  ? 53   ASN A CA  1 
ATOM   364  C  C   . ASN A 1 76  ? 1.431   17.312  15.020 1.00 7.75  ? 53   ASN A C   1 
ATOM   365  O  O   . ASN A 1 76  ? 1.573   18.506  15.318 1.00 10.25 ? 53   ASN A O   1 
ATOM   366  C  CB  . ASN A 1 76  ? 3.774   16.562  15.385 1.00 7.43  ? 53   ASN A CB  1 
ATOM   367  C  CG  . ASN A 1 76  ? 3.511   15.718  16.626 1.00 8.10  ? 53   ASN A CG  1 
ATOM   368  O  OD1 . ASN A 1 76  ? 3.146   14.547  16.479 1.00 9.49  ? 53   ASN A OD1 1 
ATOM   369  N  ND2 . ASN A 1 76  ? 3.628   16.304  17.814 1.00 8.77  ? 53   ASN A ND2 1 
ATOM   370  N  N   . TYR A 1 77  ? 0.258   16.715  15.138 1.00 6.63  ? 54   TYR A N   1 
ATOM   371  C  CA  . TYR A 1 77  ? -0.990  17.347  15.527 1.00 7.03  ? 54   TYR A CA  1 
ATOM   372  C  C   . TYR A 1 77  ? -1.371  16.836  16.898 1.00 6.81  ? 54   TYR A C   1 
ATOM   373  O  O   . TYR A 1 77  ? -1.857  15.690  17.016 1.00 7.44  ? 54   TYR A O   1 
ATOM   374  C  CB  . TYR A 1 77  ? -2.074  17.077  14.483 1.00 7.50  ? 54   TYR A CB  1 
ATOM   375  C  CG  . TYR A 1 77  ? -1.719  17.658  13.129 1.00 7.20  ? 54   TYR A CG  1 
ATOM   376  C  CD1 . TYR A 1 77  ? -0.980  16.938  12.206 1.00 7.44  ? 54   TYR A CD1 1 
ATOM   377  C  CD2 . TYR A 1 77  ? -2.150  18.938  12.786 1.00 7.94  ? 54   TYR A CD2 1 
ATOM   378  C  CE1 . TYR A 1 77  ? -0.602  17.516  10.996 1.00 7.61  ? 54   TYR A CE1 1 
ATOM   379  C  CE2 . TYR A 1 77  ? -1.814  19.512  11.576 1.00 8.45  ? 54   TYR A CE2 1 
ATOM   380  C  CZ  . TYR A 1 77  ? -1.028  18.802  10.705 1.00 8.36  ? 54   TYR A CZ  1 
ATOM   381  O  OH  . TYR A 1 77  ? -0.711  19.368  9.459  1.00 9.46  ? 54   TYR A OH  1 
ATOM   382  N  N   . GLN A 1 78  ? -1.122  17.646  17.909 1.00 6.59  ? 55   GLN A N   1 
ATOM   383  C  CA  . GLN A 1 78  ? -1.411  17.312  19.293 1.00 6.55  ? 55   GLN A CA  1 
ATOM   384  C  C   . GLN A 1 78  ? -2.865  17.671  19.562 1.00 6.93  ? 55   GLN A C   1 
ATOM   385  O  O   . GLN A 1 78  ? -3.174  18.772  20.003 1.00 7.19  ? 55   GLN A O   1 
ATOM   386  C  CB  . GLN A 1 78  ? -0.456  18.038  20.242 1.00 6.50  ? 55   GLN A CB  1 
ATOM   387  C  CG  . GLN A 1 78  ? 0.979   17.564  20.107 1.00 6.80  ? 55   GLN A CG  1 
ATOM   388  C  CD  . GLN A 1 78  ? 1.872   18.315  21.040 1.00 7.99  ? 55   GLN A CD  1 
ATOM   389  O  OE1 . GLN A 1 78  ? 1.981   18.006  22.220 1.00 7.46  ? 55   GLN A OE1 1 
ATOM   390  N  NE2 . GLN A 1 78  ? 2.510   19.348  20.536 1.00 9.84  ? 55   GLN A NE2 1 
ATOM   391  N  N   . GLU A 1 79  ? -3.754  16.760  19.191 1.00 6.86  ? 56   GLU A N   1 
ATOM   392  C  CA  . GLU A 1 79  ? -5.177  17.001  19.174 1.00 6.73  ? 56   GLU A CA  1 
ATOM   393  C  C   . GLU A 1 79  ? -5.927  15.745  19.559 1.00 6.91  ? 56   GLU A C   1 
ATOM   394  O  O   . GLU A 1 79  ? -5.457  14.643  19.276 1.00 8.05  ? 56   GLU A O   1 
ATOM   395  C  CB  . GLU A 1 79  ? -5.639  17.367  17.761 1.00 7.81  ? 56   GLU A CB  1 
ATOM   396  C  CG  . GLU A 1 79  ? -5.001  18.601  17.148 1.00 8.52  ? 56   GLU A CG  1 
ATOM   397  C  CD  . GLU A 1 79  ? -5.663  19.077  15.885 1.00 8.53  ? 56   GLU A CD  1 
ATOM   398  O  OE1 . GLU A 1 79  ? -4.936  19.361  14.903 1.00 8.73  ? 56   GLU A OE1 1 
ATOM   399  O  OE2 . GLU A 1 79  ? -6.920  19.212  15.933 1.00 10.08 ? 56   GLU A OE2 1 
ATOM   400  N  N   . MET A 1 80  ? -7.091  15.927  20.145 1.00 6.49  ? 57   MET A N   1 
ATOM   401  C  CA  . MET A 1 80  ? -8.102  14.887  20.299 1.00 6.82  ? 57   MET A CA  1 
ATOM   402  C  C   . MET A 1 80  ? -9.266  15.189  19.368 1.00 7.44  ? 57   MET A C   1 
ATOM   403  O  O   . MET A 1 80  ? -9.646  16.368  19.237 1.00 8.55  ? 57   MET A O   1 
ATOM   404  C  CB  . MET A 1 80  ? -8.587  14.812  21.741 1.00 6.87  ? 57   MET A CB  1 
ATOM   405  C  CG  . MET A 1 80  ? -7.468  14.509  22.697 1.00 6.50  ? 57   MET A CG  1 
ATOM   406  S  SD  . MET A 1 80  ? -7.918  14.462  24.443 1.00 6.87  ? 57   MET A SD  1 
ATOM   407  C  CE  . MET A 1 80  ? -8.781  12.886  24.532 1.00 6.67  ? 57   MET A CE  1 
ATOM   408  N  N   . LEU A 1 81  ? -9.865  14.158  18.770 1.00 6.89  ? 58   LEU A N   1 
ATOM   409  C  CA  . LEU A 1 81  ? -10.936 14.324  17.792 1.00 7.08  ? 58   LEU A CA  1 
ATOM   410  C  C   . LEU A 1 81  ? -12.091 13.408  18.123 1.00 7.10  ? 58   LEU A C   1 
ATOM   411  O  O   . LEU A 1 81  ? -11.879 12.263  18.581 1.00 6.86  ? 58   LEU A O   1 
ATOM   412  C  CB  . LEU A 1 81  ? -10.452 13.965  16.406 1.00 7.28  ? 58   LEU A CB  1 
ATOM   413  C  CG  . LEU A 1 81  ? -9.201  14.690  15.916 1.00 8.83  ? 58   LEU A CG  1 
ATOM   414  C  CD1 . LEU A 1 81  ? -8.783  14.143  14.586 1.00 9.84  ? 58   LEU A CD1 1 
ATOM   415  C  CD2 . LEU A 1 81  ? -9.411  16.204  15.818 1.00 10.08 ? 58   LEU A CD2 1 
ATOM   416  N  N   . ILE A 1 82  ? -13.296 13.873  17.880 1.00 7.48  ? 59   ILE A N   1 
ATOM   417  C  CA  . ILE A 1 82  ? -14.503 13.058  17.853 1.00 7.67  ? 59   ILE A CA  1 
ATOM   418  C  C   . ILE A 1 82  ? -15.085 13.172  16.460 1.00 8.10  ? 59   ILE A C   1 
ATOM   419  O  O   . ILE A 1 82  ? -15.558 14.251  16.049 1.00 9.22  ? 59   ILE A O   1 
ATOM   420  C  CB  . ILE A 1 82  ? -15.525 13.497  18.904 1.00 8.68  ? 59   ILE A CB  1 
ATOM   421  C  CG1 . ILE A 1 82  ? -14.923 13.438  20.302 1.00 9.79  ? 59   ILE A CG1 1 
ATOM   422  C  CG2 . ILE A 1 82  ? -16.785 12.644  18.759 1.00 10.38 ? 59   ILE A CG2 1 
ATOM   423  C  CD1 . ILE A 1 82  ? -15.857 13.916  21.405 1.00 11.83 ? 59   ILE A CD1 1 
ATOM   424  N  N   . VAL A 1 83  ? -14.992 12.111  15.690 1.00 7.68  ? 60   VAL A N   1 
ATOM   425  C  CA  . VAL A 1 83  ? -15.504 12.124  14.326 1.00 8.67  ? 60   VAL A CA  1 
ATOM   426  C  C   . VAL A 1 83  ? -16.951 11.686  14.387 1.00 8.16  ? 60   VAL A C   1 
ATOM   427  O  O   . VAL A 1 83  ? -17.237 10.499  14.379 1.00 9.18  ? 60   VAL A O   1 
ATOM   428  C  CB  . VAL A 1 83  ? -14.669 11.283  13.357 1.00 9.24  ? 60   VAL A CB  1 
ATOM   429  C  CG1 . VAL A 1 83  ? -15.208 11.484  11.931 1.00 10.17 ? 60   VAL A CG1 1 
ATOM   430  C  CG2 . VAL A 1 83  ? -13.196 11.642  13.409 1.00 10.60 ? 60   VAL A CG2 1 
ATOM   431  N  N   . ASP A 1 84  ? -17.861 12.652  14.392 1.00 8.30  ? 61   ASP A N   1 
ATOM   432  C  CA  . ASP A 1 84  ? -19.291 12.446  14.518 1.00 8.80  ? 61   ASP A CA  1 
ATOM   433  C  C   . ASP A 1 84  ? -20.013 12.899  13.252 1.00 9.41  ? 61   ASP A C   1 
ATOM   434  O  O   . ASP A 1 84  ? -21.205 13.231  13.319 1.00 12.82 ? 61   ASP A O   1 
ATOM   435  C  CB  . ASP A 1 84  ? -19.843 13.107  15.764 1.00 9.85  ? 61   ASP A CB  1 
ATOM   436  C  CG  . ASP A 1 84  ? -19.628 14.606  15.861 1.00 11.85 ? 61   ASP A CG  1 
ATOM   437  O  OD1 . ASP A 1 84  ? -18.901 15.157  15.060 1.00 10.45 ? 61   ASP A OD1 1 
ATOM   438  O  OD2 . ASP A 1 84  ? -20.177 15.206  16.837 1.00 18.03 ? 61   ASP A OD2 1 
ATOM   439  N  N   . VAL A 1 85  ? -19.284 12.976  12.161 1.00 9.14  ? 62   VAL A N   1 
ATOM   440  C  CA  . VAL A 1 85  ? -19.784 13.371  10.844 1.00 10.00 ? 62   VAL A CA  1 
ATOM   441  C  C   . VAL A 1 85  ? -19.526 12.203  9.894  1.00 8.60  ? 62   VAL A C   1 
ATOM   442  O  O   . VAL A 1 85  ? -18.412 11.691  9.827  1.00 8.82  ? 62   VAL A O   1 
ATOM   443  C  CB  . VAL A 1 85  ? -19.088 14.668  10.358 1.00 11.92 ? 62   VAL A CB  1 
ATOM   444  C  CG1 . VAL A 1 85  ? -19.735 15.905  10.980 1.00 13.66 ? 62   VAL A CG1 1 
ATOM   445  C  CG2 . VAL A 1 85  ? -17.589 14.660  10.588 1.00 13.46 ? 62   VAL A CG2 1 
ATOM   446  N  N   . ASP A 1 86  ? -20.561 11.849  9.145  1.00 8.84  ? 63   ASP A N   1 
ATOM   447  C  CA  . ASP A 1 86  ? -20.476 10.705  8.219  1.00 8.54  ? 63   ASP A CA  1 
ATOM   448  C  C   . ASP A 1 86  ? -19.632 11.022  6.988  1.00 7.53  ? 63   ASP A C   1 
ATOM   449  O  O   . ASP A 1 86  ? -19.545 12.177  6.588  1.00 8.65  ? 63   ASP A O   1 
ATOM   450  C  CB  . ASP A 1 86  ? -21.870 10.310  7.745  1.00 10.31 ? 63   ASP A CB  1 
ATOM   451  C  CG  . ASP A 1 86  ? -22.756 9.603   8.757  1.00 13.43 ? 63   ASP A CG  1 
ATOM   452  O  OD1 . ASP A 1 86  ? -22.241 9.153   9.792  1.00 12.83 ? 63   ASP A OD1 1 
ATOM   453  O  OD2 . ASP A 1 86  ? -23.958 9.493   8.470  1.00 17.59 ? 63   ASP A OD2 1 
ATOM   454  N  N   . ASN A 1 87  ? -19.050 9.991   6.409  1.00 7.34  ? 64   ASN A N   1 
ATOM   455  C  CA  . ASN A 1 87  ? -18.353 10.064  5.124  1.00 8.02  ? 64   ASN A CA  1 
ATOM   456  C  C   . ASN A 1 87  ? -17.301 11.142  5.116  1.00 8.44  ? 64   ASN A C   1 
ATOM   457  O  O   . ASN A 1 87  ? -17.238 12.030  4.234  1.00 9.12  ? 64   ASN A O   1 
ATOM   458  C  CB  . ASN A 1 87  ? -19.359 10.223  3.978  1.00 9.66  ? 64   ASN A CB  1 
ATOM   459  C  CG  . ASN A 1 87  ? -20.251 8.998   3.970  1.00 10.32 ? 64   ASN A CG  1 
ATOM   460  O  OD1 . ASN A 1 87  ? -19.771 7.856   4.040  1.00 12.43 ? 64   ASN A OD1 1 
ATOM   461  N  ND2 . ASN A 1 87  ? -21.555 9.206   3.930  1.00 13.57 ? 64   ASN A ND2 1 
ATOM   462  N  N   . VAL A 1 88  ? -16.389 11.069  6.075  1.00 8.02  ? 65   VAL A N   1 
ATOM   463  C  CA  . VAL A 1 88  ? -15.216 11.910  6.117  1.00 8.43  ? 65   VAL A CA  1 
ATOM   464  C  C   . VAL A 1 88  ? -13.961 11.083  6.007  1.00 8.24  ? 65   VAL A C   1 
ATOM   465  O  O   . VAL A 1 88  ? -13.898 9.972   6.526  1.00 7.95  ? 65   VAL A O   1 
ATOM   466  C  CB  . VAL A 1 88  ? -15.197 12.731  7.403  1.00 10.40 ? 65   VAL A CB  1 
ATOM   467  C  CG1 . VAL A 1 88  ? -13.908 13.494  7.675  1.00 12.18 ? 65   VAL A CG1 1 
ATOM   468  C  CG2 . VAL A 1 88  ? -16.383 13.699  7.391  1.00 11.77 ? 65   VAL A CG2 1 
ATOM   469  N  N   . SER A 1 89  ? -12.985 11.634  5.311  1.00 8.34  ? 66   SER A N   1 
ATOM   470  C  CA  . SER A 1 89  ? -11.664 11.015  5.181  1.00 8.56  ? 66   SER A CA  1 
ATOM   471  C  C   . SER A 1 89  ? -10.603 11.909  5.782  1.00 8.96  ? 66   SER A C   1 
ATOM   472  O  O   . SER A 1 89  ? -10.652 13.149  5.603  1.00 10.34 ? 66   SER A O   1 
ATOM   473  C  CB  . SER A 1 89  ? -11.298 10.771  3.742  1.00 9.22  ? 66   SER A CB  1 
ATOM   474  O  OG  . SER A 1 89  ? -12.224 9.884   3.142  1.00 10.02 ? 66   SER A OG  1 
ATOM   475  N  N   . LEU A 1 90  ? -9.624  11.344  6.500  1.00 7.94  ? 67   LEU A N   1 
ATOM   476  C  CA  . LEU A 1 90  ? -8.406  12.011  6.894  1.00 7.92  ? 67   LEU A CA  1 
ATOM   477  C  C   . LEU A 1 90  ? -7.287  11.436  6.050  1.00 8.72  ? 67   LEU A C   1 
ATOM   478  O  O   . LEU A 1 90  ? -6.995  10.255  6.169  1.00 9.77  ? 67   LEU A O   1 
ATOM   479  C  CB  . LEU A 1 90  ? -8.092  11.775  8.370  1.00 8.09  ? 67   LEU A CB  1 
ATOM   480  C  CG  . LEU A 1 90  ? -9.193  12.114  9.363  1.00 8.57  ? 67   LEU A CG  1 
ATOM   481  C  CD1 . LEU A 1 90  ? -8.684  11.980  10.783 1.00 9.16  ? 67   LEU A CD1 1 
ATOM   482  C  CD2 . LEU A 1 90  ? -9.727  13.502  9.198  1.00 9.25  ? 67   LEU A CD2 1 
ATOM   483  N  N   . VAL A 1 91  ? -6.608  12.264  5.250  1.00 8.14  ? 68   VAL A N   1 
ATOM   484  C  CA  . VAL A 1 91  ? -5.565  11.720  4.373  1.00 9.32  ? 68   VAL A CA  1 
ATOM   485  C  C   . VAL A 1 91  ? -4.303  12.562  4.491  1.00 9.08  ? 68   VAL A C   1 
ATOM   486  O  O   . VAL A 1 91  ? -4.351  13.776  4.623  1.00 9.66  ? 68   VAL A O   1 
ATOM   487  C  CB  . VAL A 1 91  ? -6.003  11.594  2.919  1.00 10.04 ? 68   VAL A CB  1 
ATOM   488  C  CG1 . VAL A 1 91  ? -7.309  10.835  2.805  1.00 10.59 ? 68   VAL A CG1 1 
ATOM   489  C  CG2 . VAL A 1 91  ? -6.156  12.933  2.238  1.00 10.93 ? 68   VAL A CG2 1 
ATOM   490  N  N   . ASN A 1 92  ? -3.171  11.898  4.371  1.00 7.96  ? 69   ASN A N   1 
ATOM   491  C  CA  . ASN A 1 92  ? -1.892  12.558  4.363  1.00 7.71  ? 69   ASN A CA  1 
ATOM   492  C  C   . ASN A 1 92  ? -1.701  13.205  2.982  1.00 7.99  ? 69   ASN A C   1 
ATOM   493  O  O   . ASN A 1 92  ? -1.740  12.524  1.978  1.00 8.75  ? 69   ASN A O   1 
ATOM   494  C  CB  . ASN A 1 92  ? -0.838  11.507  4.654  1.00 7.39  ? 69   ASN A CB  1 
ATOM   495  C  CG  . ASN A 1 92  ? 0.554   12.007  4.841  1.00 7.70  ? 69   ASN A CG  1 
ATOM   496  O  OD1 . ASN A 1 92  ? 0.976   13.013  4.268  1.00 8.17  ? 69   ASN A OD1 1 
ATOM   497  N  ND2 . ASN A 1 92  ? 1.294   11.356  5.720  1.00 7.82  ? 69   ASN A ND2 1 
ATOM   498  N  N   . ALA A 1 93  ? -1.351  14.486  2.994  1.00 8.40  ? 70   ALA A N   1 
ATOM   499  C  CA  . ALA A 1 93  ? -1.137  15.244  1.759  1.00 9.25  ? 70   ALA A CA  1 
ATOM   500  C  C   . ALA A 1 93  ? 0.049   14.695  0.978  1.00 10.03 ? 70   ALA A C   1 
ATOM   501  O  O   . ALA A 1 93  ? 0.114   14.970  -0.244 1.00 12.23 ? 70   ALA A O   1 
ATOM   502  C  CB  . ALA A 1 93  ? -0.966  16.700  2.050  1.00 10.29 ? 70   ALA A CB  1 
ATOM   503  N  N   . ALA A 1 94  ? 0.972   13.945  1.585  1.00 9.29  ? 71   ALA A N   1 
ATOM   504  C  CA  . ALA A 1 94  ? 2.093   13.369  0.847  1.00 8.90  ? 71   ALA A CA  1 
ATOM   505  C  C   . ALA A 1 94  ? 1.654   12.206  -0.038 1.00 9.37  ? 71   ALA A C   1 
ATOM   506  O  O   . ALA A 1 94  ? 2.452   11.667  -0.814 1.00 9.51  ? 71   ALA A O   1 
ATOM   507  C  CB  . ALA A 1 94  ? 3.156   12.900  1.804  1.00 9.21  ? 71   ALA A CB  1 
ATOM   508  N  N   . GLY A 1 95  ? 0.426   11.709  0.089  1.00 9.51  ? 72   GLY A N   1 
ATOM   509  C  CA  . GLY A 1 95  ? -0.110  10.740  -0.855 1.00 9.74  ? 72   GLY A CA  1 
ATOM   510  C  C   . GLY A 1 95  ? 0.658   9.430   -0.857 1.00 10.65 ? 72   GLY A C   1 
ATOM   511  O  O   . GLY A 1 95  ? 0.930   8.839   0.203  1.00 10.17 ? 72   GLY A O   1 
ATOM   512  N  N   . ASP A 1 96  ? 1.039   8.927   -2.029 1.00 9.92  ? 73   ASP A N   1 
ATOM   513  C  CA  . ASP A 1 96  ? 1.750   7.668   -2.141 1.00 10.84 ? 73   ASP A CA  1 
ATOM   514  C  C   . ASP A 1 96  ? 3.110   7.735   -1.469 1.00 9.85  ? 73   ASP A C   1 
ATOM   515  O  O   . ASP A 1 96  ? 3.654   6.675   -1.160 1.00 10.57 ? 73   ASP A O   1 
ATOM   516  C  CB  . ASP A 1 96  ? 1.912   7.291   -3.608 1.00 12.48 ? 73   ASP A CB  1 
ATOM   517  C  CG  . ASP A 1 96  ? 0.630   6.957   -4.346 1.00 16.28 ? 73   ASP A CG  1 
ATOM   518  O  OD1 . ASP A 1 96  ? -0.387  6.673   -3.706 1.00 17.54 ? 73   ASP A OD1 1 
ATOM   519  O  OD2 . ASP A 1 96  ? 0.674   7.002   -5.589 1.00 19.66 ? 73   ASP A OD2 1 
ATOM   520  N  N   . ASP A 1 97  ? 3.639   8.938   -1.247 1.00 9.06  ? 74   ASP A N   1 
ATOM   521  C  CA  . ASP A 1 97  ? 4.940   9.102   -0.621 1.00 9.49  ? 74   ASP A CA  1 
ATOM   522  C  C   . ASP A 1 97  ? 4.840   9.382   0.886  1.00 9.42  ? 74   ASP A C   1 
ATOM   523  O  O   . ASP A 1 97  ? 5.843   9.735   1.515  1.00 10.75 ? 74   ASP A O   1 
ATOM   524  C  CB  . ASP A 1 97  ? 5.754   10.194  -1.299 1.00 9.71  ? 74   ASP A CB  1 
ATOM   525  C  CG  . ASP A 1 97  ? 7.258   10.088  -1.218 1.00 9.74  ? 74   ASP A CG  1 
ATOM   526  O  OD1 . ASP A 1 97  ? 7.772   8.994   -0.883 1.00 10.18 ? 74   ASP A OD1 1 
ATOM   527  O  OD2 . ASP A 1 97  ? 7.899   11.107  -1.579 1.00 11.44 ? 74   ASP A OD2 1 
ATOM   528  N  N   . ALA A 1 98  ? 3.662   9.196   1.464  1.00 8.97  ? 75   ALA A N   1 
ATOM   529  C  CA  . ALA A 1 98  ? 3.494   9.311   2.913  1.00 9.38  ? 75   ALA A CA  1 
ATOM   530  C  C   . ALA A 1 98  ? 4.445   8.374   3.661  1.00 9.54  ? 75   ALA A C   1 
ATOM   531  O  O   . ALA A 1 98  ? 4.700   7.272   3.219  1.00 11.37 ? 75   ALA A O   1 
ATOM   532  C  CB  . ALA A 1 98  ? 2.081   8.998   3.304  1.00 10.61 ? 75   ALA A CB  1 
ATOM   533  N  N   . SER A 1 99  ? 4.896   8.836   4.833  1.00 8.75  ? 76   SER A N   1 
ATOM   534  C  CA  . SER A 1 99  ? 5.570   7.960   5.799  1.00 8.18  ? 76   SER A CA  1 
ATOM   535  C  C   . SER A 1 99  ? 4.684   7.765   7.026  1.00 7.70  ? 76   SER A C   1 
ATOM   536  O  O   . SER A 1 99  ? 4.018   8.704   7.440  1.00 8.06  ? 76   SER A O   1 
ATOM   537  C  CB  . SER A 1 99  ? 6.854   8.584   6.208  1.00 8.79  ? 76   SER A CB  1 
ATOM   538  O  OG  . SER A 1 99  ? 7.512   7.802   7.209  1.00 9.38  ? 76   SER A OG  1 
ATOM   539  N  N   . ILE A 1 100 ? 4.752   6.553   7.603  1.00 7.20  ? 77   ILE A N   1 
ATOM   540  C  CA  . ILE A 1 100 ? 4.183   6.281   8.931  1.00 7.22  ? 77   ILE A CA  1 
ATOM   541  C  C   . ILE A 1 100 ? 5.300   5.979   9.934  1.00 7.35  ? 77   ILE A C   1 
ATOM   542  O  O   . ILE A 1 100 ? 5.021   5.383   10.986 1.00 7.65  ? 77   ILE A O   1 
ATOM   543  C  CB  . ILE A 1 100 ? 3.096   5.207   8.862  1.00 8.17  ? 77   ILE A CB  1 
ATOM   544  C  CG1 . ILE A 1 100 ? 3.602   3.939   8.195  1.00 8.55  ? 77   ILE A CG1 1 
ATOM   545  C  CG2 . ILE A 1 100 ? 1.852   5.771   8.172  1.00 8.71  ? 77   ILE A CG2 1 
ATOM   546  C  CD1 . ILE A 1 100 ? 2.599   2.786   8.260  1.00 8.63  ? 77   ILE A CD1 1 
ATOM   547  N  N   . GLU A 1 101 ? 6.551   6.352   9.650  1.00 7.88  ? 78   GLU A N   1 
ATOM   548  C  CA  . GLU A 1 101 ? 7.653   6.058   10.548 1.00 8.44  ? 78   GLU A CA  1 
ATOM   549  C  C   . GLU A 1 101 ? 7.690   6.987   11.753 1.00 8.63  ? 78   GLU A C   1 
ATOM   550  O  O   . GLU A 1 101 ? 7.605   8.220   11.652 1.00 9.46  ? 78   GLU A O   1 
ATOM   551  C  CB  . GLU A 1 101 ? 8.981   6.197   9.828  1.00 10.21 ? 78   GLU A CB  1 
ATOM   552  C  CG  . GLU A 1 101 ? 9.133   5.318   8.615  1.00 13.29 ? 78   GLU A CG  1 
ATOM   553  C  CD  . GLU A 1 101 ? 10.135  5.920   7.619  0.80 16.08 ? 78   GLU A CD  1 
ATOM   554  O  OE1 . GLU A 1 101 ? 11.298  5.461   7.757  0.80 18.04 ? 78   GLU A OE1 1 
ATOM   555  O  OE2 . GLU A 1 101 ? 9.874   6.793   6.727  0.80 17.09 ? 78   GLU A OE2 1 
ATOM   556  N  N   . LEU A 1 102 ? 7.962   6.340   12.909 1.00 8.37  ? 79   LEU A N   1 
ATOM   557  C  CA  . LEU A 1 102 ? 8.331   7.064   14.116 1.00 7.73  ? 79   LEU A CA  1 
ATOM   558  C  C   . LEU A 1 102 ? 9.838   7.319   14.121 1.00 8.46  ? 79   LEU A C   1 
ATOM   559  O  O   . LEU A 1 102 ? 10.580  6.636   13.419 1.00 10.82 ? 79   LEU A O   1 
ATOM   560  C  CB  . LEU A 1 102 ? 7.958   6.249   15.347 1.00 8.00  ? 79   LEU A CB  1 
ATOM   561  C  CG  . LEU A 1 102 ? 6.470   5.904   15.516 1.00 8.15  ? 79   LEU A CG  1 
ATOM   562  C  CD1 . LEU A 1 102 ? 6.233   5.013   16.753 1.00 8.02  ? 79   LEU A CD1 1 
ATOM   563  C  CD2 . LEU A 1 102 ? 5.663   7.169   15.666 1.00 11.49 ? 79   LEU A CD2 1 
ATOM   564  N  N   . ALA A 1 103 ? 10.286  8.227   14.967 1.00 7.68  ? 80   ALA A N   1 
ATOM   565  C  CA  . ALA A 1 103 ? 11.700  8.526   15.106 1.00 8.35  ? 80   ALA A CA  1 
ATOM   566  C  C   . ALA A 1 103 ? 11.987  8.912   16.549 1.00 7.70  ? 80   ALA A C   1 
ATOM   567  O  O   . ALA A 1 103 ? 11.095  9.191   17.332 1.00 7.67  ? 80   ALA A O   1 
ATOM   568  C  CB  . ALA A 1 103 ? 12.092  9.663   14.154 1.00 10.09 ? 80   ALA A CB  1 
ATOM   569  N  N   . ASP A 1 104 ? 13.274  9.011   16.875 1.00 8.04  ? 81   ASP A N   1 
ATOM   570  C  CA  . ASP A 1 104 ? 13.701  9.522   18.216 1.00 8.80  ? 81   ASP A CA  1 
ATOM   571  C  C   . ASP A 1 104 ? 13.064  8.709   19.347 1.00 7.56  ? 81   ASP A C   1 
ATOM   572  O  O   . ASP A 1 104 ? 12.532  9.290   20.268 1.00 7.79  ? 81   ASP A O   1 
ATOM   573  C  CB  . ASP A 1 104 ? 13.497  11.022  18.322 1.00 10.06 ? 81   ASP A CB  1 
ATOM   574  C  CG  . ASP A 1 104 ? 14.304  11.828  17.317 1.00 14.02 ? 81   ASP A CG  1 
ATOM   575  O  OD1 . ASP A 1 104 ? 15.456  11.443  17.055 1.00 19.92 ? 81   ASP A OD1 1 
ATOM   576  O  OD2 . ASP A 1 104 ? 13.770  12.828  16.821 1.00 17.23 ? 81   ASP A OD2 1 
ATOM   577  N  N   . SER A 1 105 ? 13.100  7.387   19.210 1.00 7.37  ? 82   SER A N   1 
ATOM   578  C  CA  . SER A 1 105 ? 12.665  6.503   20.286 1.00 8.17  ? 82   SER A CA  1 
ATOM   579  C  C   . SER A 1 105 ? 11.172  6.644   20.592 1.00 7.07  ? 82   SER A C   1 
ATOM   580  O  O   . SER A 1 105 ? 10.743  6.447   21.736 1.00 7.83  ? 82   SER A O   1 
ATOM   581  C  CB  . SER A 1 105 ? 13.505  6.630   21.538 1.00 8.25  ? 82   SER A CB  1 
ATOM   582  O  OG  . SER A 1 105 ? 14.863  6.362   21.179 1.00 10.26 ? 82   SER A OG  1 
ATOM   583  N  N   . GLY A 1 106 ? 10.411  7.035   19.562 1.00 7.09  ? 83   GLY A N   1 
ATOM   584  C  CA  . GLY A 1 106 ? 8.962   7.240   19.659 1.00 6.86  ? 83   GLY A CA  1 
ATOM   585  C  C   . GLY A 1 106 ? 8.562   8.709   19.694 1.00 6.57  ? 83   GLY A C   1 
ATOM   586  O  O   . GLY A 1 106 ? 7.387   9.016   19.511 1.00 6.89  ? 83   GLY A O   1 
ATOM   587  N  N   . VAL A 1 107 ? 9.475   9.614   20.061 1.00 7.01  ? 84   VAL A N   1 
ATOM   588  C  CA  . VAL A 1 107 ? 9.135   10.987  20.367 1.00 7.17  ? 84   VAL A CA  1 
ATOM   589  C  C   . VAL A 1 107 ? 8.747   11.805  19.138 1.00 7.96  ? 84   VAL A C   1 
ATOM   590  O  O   . VAL A 1 107 ? 7.926   12.712  19.263 1.00 8.75  ? 84   VAL A O   1 
ATOM   591  C  CB  . VAL A 1 107 ? 10.290  11.652  21.153 1.00 7.69  ? 84   VAL A CB  1 
ATOM   592  C  CG1 . VAL A 1 107 ? 10.049  13.135  21.388 1.00 9.38  ? 84   VAL A CG1 1 
ATOM   593  C  CG2 . VAL A 1 107 ? 10.534  10.932  22.478 1.00 7.87  ? 84   VAL A CG2 1 
ATOM   594  N  N   . SER A 1 108 ? 9.359   11.506  18.010 1.00 7.95  ? 85   SER A N   1 
ATOM   595  C  CA  A SER A 1 108 ? 9.220   12.277  16.778 0.50 8.16  ? 85   SER A CA  1 
ATOM   596  C  CA  B SER A 1 108 ? 9.111   12.303  16.813 0.50 8.70  ? 85   SER A CA  1 
ATOM   597  C  C   . SER A 1 108 ? 8.632   11.395  15.685 1.00 8.63  ? 85   SER A C   1 
ATOM   598  O  O   . SER A 1 108 ? 8.421   10.205  15.875 1.00 8.20  ? 85   SER A O   1 
ATOM   599  C  CB  A SER A 1 108 ? 10.574  12.832  16.355 0.50 8.69  ? 85   SER A CB  1 
ATOM   600  C  CB  B SER A 1 108 ? 10.338  13.104  16.444 0.50 10.27 ? 85   SER A CB  1 
ATOM   601  O  OG  A SER A 1 108 ? 11.070  13.666  17.387 0.50 10.37 ? 85   SER A OG  1 
ATOM   602  O  OG  B SER A 1 108 ? 11.302  12.264  15.841 0.50 12.66 ? 85   SER A OG  1 
ATOM   603  N  N   . VAL A 1 109 ? 8.384   11.977  14.499 1.00 8.86  ? 86   VAL A N   1 
ATOM   604  C  CA  . VAL A 1 109 ? 7.967   11.239  13.322 1.00 8.54  ? 86   VAL A CA  1 
ATOM   605  C  C   . VAL A 1 109 ? 8.748   11.732  12.105 1.00 8.65  ? 86   VAL A C   1 
ATOM   606  O  O   . VAL A 1 109 ? 9.321   12.809  12.132 1.00 10.28 ? 86   VAL A O   1 
ATOM   607  C  CB  . VAL A 1 109 ? 6.452   11.326  13.042 1.00 8.38  ? 86   VAL A CB  1 
ATOM   608  C  CG1 . VAL A 1 109 ? 5.678   10.699  14.180 1.00 8.50  ? 86   VAL A CG1 1 
ATOM   609  C  CG2 . VAL A 1 109 ? 5.993   12.780  12.833 1.00 9.50  ? 86   VAL A CG2 1 
ATOM   610  N  N   . SER A 1 110 ? 8.709   10.942  11.050 1.00 8.83  ? 87   SER A N   1 
ATOM   611  C  CA  . SER A 1 110 ? 9.179   11.329  9.723  1.00 10.02 ? 87   SER A CA  1 
ATOM   612  C  C   . SER A 1 110 ? 8.613   12.668  9.317  1.00 9.96  ? 87   SER A C   1 
ATOM   613  O  O   . SER A 1 110 ? 7.465   12.971  9.567  1.00 10.49 ? 87   SER A O   1 
ATOM   614  C  CB  . SER A 1 110 ? 8.677   10.330  8.739  1.00 10.65 ? 87   SER A CB  1 
ATOM   615  O  OG  . SER A 1 110 ? 8.956   10.737  7.389  1.00 12.75 ? 87   SER A OG  1 
ATOM   616  N  N   . ASP A 1 111 ? 9.389   13.446  8.547  1.00 11.46 ? 88   ASP A N   1 
ATOM   617  C  CA  . ASP A 1 111 ? 8.846   14.682  7.962  1.00 12.03 ? 88   ASP A CA  1 
ATOM   618  C  C   . ASP A 1 111 ? 7.765   14.480  6.879  1.00 11.61 ? 88   ASP A C   1 
ATOM   619  O  O   . ASP A 1 111 ? 7.176   15.486  6.500  1.00 12.02 ? 88   ASP A O   1 
ATOM   620  C  CB  . ASP A 1 111 ? 9.948   15.642  7.505  1.00 15.95 ? 88   ASP A CB  1 
ATOM   621  C  CG  . ASP A 1 111 ? 10.731  15.137  6.320  1.00 20.98 ? 88   ASP A CG  1 
ATOM   622  O  OD1 . ASP A 1 111 ? 10.391  14.072  5.769  1.00 19.04 ? 88   ASP A OD1 1 
ATOM   623  O  OD2 . ASP A 1 111 ? 11.741  15.828  5.972  1.00 24.82 ? 88   ASP A OD2 1 
ATOM   624  N  N   . LYS A 1 112 ? 7.495   13.257  6.417  1.00 10.28 ? 89   LYS A N   1 
ATOM   625  C  CA  . LYS A 1 112 ? 6.360   12.968  5.533  1.00 10.15 ? 89   LYS A CA  1 
ATOM   626  C  C   . LYS A 1 112 ? 5.172   12.286  6.255  1.00 8.31  ? 89   LYS A C   1 
ATOM   627  O  O   . LYS A 1 112 ? 4.300   11.728  5.627  1.00 8.52  ? 89   LYS A O   1 
ATOM   628  C  CB  . LYS A 1 112 ? 6.809   12.118  4.353  1.00 11.08 ? 89   LYS A CB  1 
ATOM   629  C  CG  . LYS A 1 112 ? 7.711   12.914  3.383  1.00 12.20 ? 89   LYS A CG  1 
ATOM   630  C  CD  . LYS A 1 112 ? 8.012   12.142  2.112  1.00 16.72 ? 89   LYS A CD  1 
ATOM   631  C  CE  . LYS A 1 112 ? 8.883   12.891  1.102  1.00 18.36 ? 89   LYS A CE  1 
ATOM   632  N  NZ  . LYS A 1 112 ? 8.266   14.189  0.808  1.00 21.33 ? 89   LYS A NZ  1 
ATOM   633  N  N   . ALA A 1 113 ? 5.229   12.288  7.581  1.00 7.83  ? 90   ALA A N   1 
ATOM   634  C  CA  . ALA A 1 113 ? 4.189   11.706  8.416  1.00 7.20  ? 90   ALA A CA  1 
ATOM   635  C  C   . ALA A 1 113 ? 3.212   12.763  8.878  1.00 7.01  ? 90   ALA A C   1 
ATOM   636  O  O   . ALA A 1 113 ? 3.541   13.918  9.090  1.00 7.25  ? 90   ALA A O   1 
ATOM   637  C  CB  . ALA A 1 113 ? 4.771   10.964  9.600  1.00 7.15  ? 90   ALA A CB  1 
ATOM   638  N  N   . VAL A 1 114 ? 1.984   12.285  9.098  1.00 6.98  ? 91   VAL A N   1 
ATOM   639  C  CA  . VAL A 1 114 ? 0.944   13.005  9.817  1.00 7.01  ? 91   VAL A CA  1 
ATOM   640  C  C   . VAL A 1 114 ? 0.614   12.220  11.087 1.00 6.54  ? 91   VAL A C   1 
ATOM   641  O  O   . VAL A 1 114 ? 0.081   11.115  10.972 1.00 7.10  ? 91   VAL A O   1 
ATOM   642  C  CB  . VAL A 1 114 ? -0.330  13.198  8.978  1.00 7.22  ? 91   VAL A CB  1 
ATOM   643  C  CG1 . VAL A 1 114 ? -1.490  13.757  9.772  1.00 7.75  ? 91   VAL A CG1 1 
ATOM   644  C  CG2 . VAL A 1 114 ? -0.106  14.076  7.767  1.00 7.13  ? 91   VAL A CG2 1 
ATOM   645  N  N   . ARG A 1 115 ? 0.937   12.785  12.245 1.00 6.41  ? 92   ARG A N   1 
ATOM   646  C  CA  . ARG A 1 115 ? 0.624   12.099  13.499 1.00 6.19  ? 92   ARG A CA  1 
ATOM   647  C  C   . ARG A 1 115 ? -0.447  12.887  14.226 1.00 5.92  ? 92   ARG A C   1 
ATOM   648  O  O   . ARG A 1 115 ? -0.358  14.122  14.341 1.00 6.63  ? 92   ARG A O   1 
ATOM   649  C  CB  . ARG A 1 115 ? 1.863   11.954  14.373 1.00 6.39  ? 92   ARG A CB  1 
ATOM   650  C  CG  . ARG A 1 115 ? 1.547   11.281  15.709 1.00 6.37  ? 92   ARG A CG  1 
ATOM   651  C  CD  . ARG A 1 115 ? 2.712   10.747  16.501 1.00 6.92  ? 92   ARG A CD  1 
ATOM   652  N  NE  . ARG A 1 115 ? 3.581   11.829  16.906 1.00 7.01  ? 92   ARG A NE  1 
ATOM   653  C  CZ  . ARG A 1 115 ? 4.762   11.669  17.504 1.00 7.84  ? 92   ARG A CZ  1 
ATOM   654  N  NH1 . ARG A 1 115 ? 5.158   10.491  17.933 1.00 7.80  ? 92   ARG A NH1 1 
ATOM   655  N  NH2 . ARG A 1 115 ? 5.572   12.691  17.623 1.00 7.78  ? 92   ARG A NH2 1 
ATOM   656  N  N   . ILE A 1 116 ? -1.500  12.191  14.659 1.00 5.80  ? 93   ILE A N   1 
ATOM   657  C  CA  . ILE A 1 116 ? -2.557  12.729  15.495 1.00 5.75  ? 93   ILE A CA  1 
ATOM   658  C  C   . ILE A 1 116 ? -2.353  12.068  16.859 1.00 5.34  ? 93   ILE A C   1 
ATOM   659  O  O   . ILE A 1 116 ? -2.462  10.843  16.961 1.00 6.17  ? 93   ILE A O   1 
ATOM   660  C  CB  . ILE A 1 116 ? -3.964  12.472  14.931 1.00 6.21  ? 93   ILE A CB  1 
ATOM   661  C  CG1 . ILE A 1 116 ? -4.042  12.845  13.457 1.00 6.47  ? 93   ILE A CG1 1 
ATOM   662  C  CG2 . ILE A 1 116 ? -5.003  13.204  15.790 1.00 6.52  ? 93   ILE A CG2 1 
ATOM   663  C  CD1 . ILE A 1 116 ? -5.373  12.502  12.775 1.00 7.07  ? 93   ILE A CD1 1 
ATOM   664  N  N   . THR A 1 117 ? -1.985  12.872  17.851 1.00 5.34  ? 94   THR A N   1 
ATOM   665  C  CA  . THR A 1 117 ? -1.560  12.322  19.146 1.00 5.37  ? 94   THR A CA  1 
ATOM   666  C  C   . THR A 1 117 ? -2.176  13.051  20.312 1.00 5.84  ? 94   THR A C   1 
ATOM   667  O  O   . THR A 1 117 ? -2.349  14.281  20.276 1.00 6.46  ? 94   THR A O   1 
ATOM   668  C  CB  . THR A 1 117 ? -0.047  12.305  19.231 1.00 6.35  ? 94   THR A CB  1 
ATOM   669  O  OG1 . THR A 1 117 ? 0.347   11.679  20.466 1.00 6.51  ? 94   THR A OG1 1 
ATOM   670  C  CG2 . THR A 1 117 ? 0.619   13.654  19.073 1.00 6.44  ? 94   THR A CG2 1 
ATOM   671  N  N   . SER A 1 118 ? -2.436  12.293  21.381 1.00 5.62  ? 95   SER A N   1 
ATOM   672  C  CA  . SER A 1 118 ? -2.829  12.866  22.672 1.00 5.47  ? 95   SER A CA  1 
ATOM   673  C  C   . SER A 1 118 ? -2.397  11.870  23.742 1.00 5.57  ? 95   SER A C   1 
ATOM   674  O  O   . SER A 1 118 ? -1.786  10.866  23.417 1.00 5.66  ? 95   SER A O   1 
ATOM   675  C  CB  . SER A 1 118 ? -4.318  13.189  22.695 1.00 5.99  ? 95   SER A CB  1 
ATOM   676  O  OG  . SER A 1 118 ? -5.107  11.992  22.829 1.00 6.22  ? 95   SER A OG  1 
ATOM   677  N  N   . TYR A 1 119 ? -2.660  12.195  25.016 1.00 5.57  ? 96   TYR A N   1 
ATOM   678  C  CA  . TYR A 1 119 ? -1.882  11.563  26.074 1.00 6.04  ? 96   TYR A CA  1 
ATOM   679  C  C   . TYR A 1 119 ? -2.651  11.173  27.314 1.00 5.82  ? 96   TYR A C   1 
ATOM   680  O  O   . TYR A 1 119 ? -2.000  10.765  28.276 1.00 6.14  ? 96   TYR A O   1 
ATOM   681  C  CB  . TYR A 1 119 ? -0.734  12.507  26.463 1.00 5.95  ? 96   TYR A CB  1 
ATOM   682  C  CG  . TYR A 1 119 ? -1.187  13.872  26.924 1.00 6.14  ? 96   TYR A CG  1 
ATOM   683  C  CD1 . TYR A 1 119 ? -1.522  14.130  28.246 1.00 6.10  ? 96   TYR A CD1 1 
ATOM   684  C  CD2 . TYR A 1 119 ? -1.303  14.931  26.036 1.00 6.68  ? 96   TYR A CD2 1 
ATOM   685  C  CE1 . TYR A 1 119 ? -1.929  15.372  28.660 1.00 6.58  ? 96   TYR A CE1 1 
ATOM   686  C  CE2 . TYR A 1 119 ? -1.718  16.168  26.429 1.00 7.51  ? 96   TYR A CE2 1 
ATOM   687  C  CZ  . TYR A 1 119 ? -2.011  16.407  27.748 1.00 6.89  ? 96   TYR A CZ  1 
ATOM   688  O  OH  . TYR A 1 119 ? -2.417  17.675  28.121 1.00 8.26  ? 96   TYR A OH  1 
ATOM   689  N  N   . TYR A 1 120 ? -3.954  11.307  27.333 1.00 5.43  ? 97   TYR A N   1 
ATOM   690  C  CA  . TYR A 1 120 ? -4.664  10.881  28.572 1.00 5.07  ? 97   TYR A CA  1 
ATOM   691  C  C   . TYR A 1 120 ? -4.695  9.351   28.712 1.00 5.27  ? 97   TYR A C   1 
ATOM   692  O  O   . TYR A 1 120 ? -4.752  8.639   27.719 1.00 5.59  ? 97   TYR A O   1 
ATOM   693  C  CB  . TYR A 1 120 ? -6.113  11.376  28.533 1.00 5.18  ? 97   TYR A CB  1 
ATOM   694  C  CG  . TYR A 1 120 ? -6.383  12.878  28.472 1.00 5.08  ? 97   TYR A CG  1 
ATOM   695  C  CD1 . TYR A 1 120 ? -5.462  13.821  28.918 1.00 5.18  ? 97   TYR A CD1 1 
ATOM   696  C  CD2 . TYR A 1 120 ? -7.603  13.343  27.994 1.00 6.01  ? 97   TYR A CD2 1 
ATOM   697  C  CE1 . TYR A 1 120 ? -5.752  15.176  28.881 1.00 5.78  ? 97   TYR A CE1 1 
ATOM   698  C  CE2 . TYR A 1 120 ? -7.900  14.693  27.959 1.00 6.18  ? 97   TYR A CE2 1 
ATOM   699  C  CZ  . TYR A 1 120 ? -6.971  15.612  28.400 1.00 5.68  ? 97   TYR A CZ  1 
ATOM   700  O  OH  . TYR A 1 120 ? -7.288  16.937  28.374 1.00 6.54  ? 97   TYR A OH  1 
ATOM   701  N  N   . GLY A 1 121 ? -4.673  8.894   29.963 1.00 5.65  ? 98   GLY A N   1 
ATOM   702  C  CA  . GLY A 1 121 ? -4.786  7.472   30.236 1.00 5.79  ? 98   GLY A CA  1 
ATOM   703  C  C   . GLY A 1 121 ? -5.409  7.229   31.592 1.00 6.09  ? 98   GLY A C   1 
ATOM   704  O  O   . GLY A 1 121 ? -5.617  8.134   32.397 1.00 6.49  ? 98   GLY A O   1 
ATOM   705  N  N   . HIS A 1 122 ? -5.725  5.960   31.803 1.00 5.72  ? 99   HIS A N   1 
ATOM   706  C  CA  . HIS A 1 122 ? -6.419  5.537   33.007 1.00 5.77  ? 99   HIS A CA  1 
ATOM   707  C  C   . HIS A 1 122 ? -5.569  5.801   34.238 1.00 5.89  ? 99   HIS A C   1 
ATOM   708  O  O   . HIS A 1 122 ? -4.389  5.488   34.285 1.00 6.70  ? 99   HIS A O   1 
ATOM   709  C  CB  . HIS A 1 122 ? -6.721  4.051   32.939 1.00 6.07  ? 99   HIS A CB  1 
ATOM   710  C  CG  . HIS A 1 122 ? -7.482  3.560   34.124 1.00 5.83  ? 99   HIS A CG  1 
ATOM   711  N  ND1 . HIS A 1 122 ? -8.859  3.554   34.127 1.00 6.68  ? 99   HIS A ND1 1 
ATOM   712  C  CD2 . HIS A 1 122 ? -7.061  3.072   35.333 1.00 6.17  ? 99   HIS A CD2 1 
ATOM   713  C  CE1 . HIS A 1 122 ? -9.235  3.068   35.336 1.00 7.50  ? 99   HIS A CE1 1 
ATOM   714  N  NE2 . HIS A 1 122 ? -8.186  2.781   36.071 1.00 6.97  ? 99   HIS A NE2 1 
ATOM   715  N  N   . GLY A 1 123 ? -6.199  6.407   35.253 1.00 6.50  ? 100  GLY A N   1 
ATOM   716  C  CA  . GLY A 1 123 ? -5.580  6.595   36.568 1.00 6.72  ? 100  GLY A CA  1 
ATOM   717  C  C   . GLY A 1 123 ? -5.211  8.035   36.885 1.00 6.97  ? 100  GLY A C   1 
ATOM   718  O  O   . GLY A 1 123 ? -4.720  8.301   37.983 1.00 8.11  ? 100  GLY A O   1 
ATOM   719  N  N   . TYR A 1 124 ? -5.396  8.909   35.905 1.00 6.47  ? 101  TYR A N   1 
ATOM   720  C  CA  . TYR A 1 124 ? -5.038  10.321  36.134 1.00 6.77  ? 101  TYR A CA  1 
ATOM   721  C  C   . TYR A 1 124 ? -6.125  11.282  35.722 1.00 6.73  ? 101  TYR A C   1 
ATOM   722  O  O   . TYR A 1 124 ? -6.852  11.025  34.774 1.00 7.69  ? 101  TYR A O   1 
ATOM   723  C  CB  . TYR A 1 124 ? -3.848  10.739  35.266 1.00 7.46  ? 101  TYR A CB  1 
ATOM   724  C  CG  . TYR A 1 124 ? -2.577  9.990   35.632 1.00 7.60  ? 101  TYR A CG  1 
ATOM   725  C  CD1 . TYR A 1 124 ? -2.283  8.775   35.037 1.00 8.63  ? 101  TYR A CD1 1 
ATOM   726  C  CD2 . TYR A 1 124 ? -1.695  10.485  36.586 1.00 7.42  ? 101  TYR A CD2 1 
ATOM   727  C  CE1 . TYR A 1 124 ? -1.141  8.076   35.369 1.00 9.90  ? 101  TYR A CE1 1 
ATOM   728  C  CE2 . TYR A 1 124 ? -0.544  9.796   36.928 1.00 9.01  ? 101  TYR A CE2 1 
ATOM   729  C  CZ  . TYR A 1 124 ? -0.271  8.589   36.309 1.00 9.68  ? 101  TYR A CZ  1 
ATOM   730  O  OH  . TYR A 1 124 ? 0.846   7.870   36.581 1.00 12.36 ? 101  TYR A OH  1 
ATOM   731  N  N   . THR A 1 125 ? -6.236  12.365  36.478 1.00 6.99  ? 102  THR A N   1 
ATOM   732  C  CA  . THR A 1 125 ? -7.038  13.534  36.114 1.00 6.94  ? 102  THR A CA  1 
ATOM   733  C  C   . THR A 1 125 ? -6.133  14.636  35.568 1.00 6.20  ? 102  THR A C   1 
ATOM   734  O  O   . THR A 1 125 ? -4.949  14.725  35.917 1.00 7.66  ? 102  THR A O   1 
ATOM   735  C  CB  . THR A 1 125 ? -7.862  13.934  37.337 1.00 7.26  ? 102  THR A CB  1 
ATOM   736  O  OG1 . THR A 1 125 ? -9.032  13.114  37.388 1.00 8.07  ? 102  THR A OG1 1 
ATOM   737  C  CG2 . THR A 1 125 ? -8.311  15.377  37.352 1.00 7.36  ? 102  THR A CG2 1 
ATOM   738  N  N   . TYR A 1 126 ? -6.692  15.431  34.657 1.00 6.25  ? 103  TYR A N   1 
ATOM   739  C  CA  . TYR A 1 126 ? -5.933  16.425  33.885 1.00 6.18  ? 103  TYR A CA  1 
ATOM   740  C  C   . TYR A 1 126 ? -6.616  17.795  33.981 1.00 6.40  ? 103  TYR A C   1 
ATOM   741  O  O   . TYR A 1 126 ? -7.826  17.898  33.771 1.00 6.42  ? 103  TYR A O   1 
ATOM   742  C  CB  . TYR A 1 126 ? -5.875  15.981  32.416 1.00 6.49  ? 103  TYR A CB  1 
ATOM   743  C  CG  . TYR A 1 126 ? -5.131  14.678  32.209 1.00 6.09  ? 103  TYR A CG  1 
ATOM   744  C  CD1 . TYR A 1 126 ? -5.772  13.455  32.358 1.00 6.25  ? 103  TYR A CD1 1 
ATOM   745  C  CD2 . TYR A 1 126 ? -3.777  14.674  31.950 1.00 6.30  ? 103  TYR A CD2 1 
ATOM   746  C  CE1 . TYR A 1 126 ? -5.082  12.262  32.217 1.00 6.81  ? 103  TYR A CE1 1 
ATOM   747  C  CE2 . TYR A 1 126 ? -3.067  13.490  31.779 1.00 6.53  ? 103  TYR A CE2 1 
ATOM   748  C  CZ  . TYR A 1 126 ? -3.732  12.287  31.920 1.00 6.26  ? 103  TYR A CZ  1 
ATOM   749  O  OH  . TYR A 1 126 ? -3.064  11.084  31.783 1.00 6.25  ? 103  TYR A OH  1 
ATOM   750  N  N   . TYR A 1 127 ? -5.818  18.827  34.289 1.00 6.43  ? 104  TYR A N   1 
ATOM   751  C  CA  . TYR A 1 127 ? -6.385  20.170  34.311 1.00 6.23  ? 104  TYR A CA  1 
ATOM   752  C  C   . TYR A 1 127 ? -6.840  20.624  32.947 1.00 6.48  ? 104  TYR A C   1 
ATOM   753  O  O   . TYR A 1 127 ? -7.702  21.497  32.858 1.00 7.22  ? 104  TYR A O   1 
ATOM   754  C  CB  . TYR A 1 127 ? -5.404  21.172  34.880 1.00 6.67  ? 104  TYR A CB  1 
ATOM   755  C  CG  . TYR A 1 127 ? -5.242  21.220  36.381 1.00 7.19  ? 104  TYR A CG  1 
ATOM   756  C  CD1 . TYR A 1 127 ? -5.229  20.086  37.173 1.00 7.68  ? 104  TYR A CD1 1 
ATOM   757  C  CD2 . TYR A 1 127 ? -5.012  22.447  37.013 1.00 8.06  ? 104  TYR A CD2 1 
ATOM   758  C  CE1 . TYR A 1 127 ? -4.986  20.139  38.528 1.00 8.69  ? 104  TYR A CE1 1 
ATOM   759  C  CE2 . TYR A 1 127 ? -4.781  22.507  38.384 1.00 8.67  ? 104  TYR A CE2 1 
ATOM   760  C  CZ  . TYR A 1 127 ? -4.752  21.352  39.124 1.00 8.38  ? 104  TYR A CZ  1 
ATOM   761  O  OH  . TYR A 1 127 ? -4.513  21.480  40.487 1.00 11.40 ? 104  TYR A OH  1 
ATOM   762  N  N   . SER A 1 128 ? -6.335  20.025  31.855 1.00 5.99  ? 105  SER A N   1 
ATOM   763  C  CA  . SER A 1 128 ? -6.764  20.387  30.526 1.00 6.44  ? 105  SER A CA  1 
ATOM   764  C  C   . SER A 1 128 ? -8.099  19.767  30.130 1.00 6.21  ? 105  SER A C   1 
ATOM   765  O  O   . SER A 1 128 ? -8.609  20.082  29.053 1.00 7.06  ? 105  SER A O   1 
ATOM   766  C  CB  . SER A 1 128 ? -5.723  19.957  29.525 1.00 6.50  ? 105  SER A CB  1 
ATOM   767  O  OG  . SER A 1 128 ? -5.564  18.536  29.551 1.00 6.39  ? 105  SER A OG  1 
ATOM   768  N  N   . MET A 1 129 ? -8.637  18.808  30.909 1.00 6.59  ? 106  MET A N   1 
ATOM   769  C  CA  . MET A 1 129 ? -9.786  18.055  30.459 1.00 6.16  ? 106  MET A CA  1 
ATOM   770  C  C   . MET A 1 129 ? -11.091 18.808  30.694 1.00 7.05  ? 106  MET A C   1 
ATOM   771  O  O   . MET A 1 129 ? -11.387 19.244  31.813 1.00 7.31  ? 106  MET A O   1 
ATOM   772  C  CB  . MET A 1 129 ? -9.839  16.697  31.167 1.00 6.48  ? 106  MET A CB  1 
ATOM   773  C  CG  . MET A 1 129 ? -11.044 15.867  30.719 1.00 7.21  ? 106  MET A CG  1 
ATOM   774  S  SD  . MET A 1 129 ? -11.142 14.224  31.440 1.00 7.11  ? 106  MET A SD  1 
ATOM   775  C  CE  . MET A 1 129 ? -9.850  13.317  30.565 1.00 8.06  ? 106  MET A CE  1 
ATOM   776  N  N   . GLY A 1 130 ? -11.865 18.941  29.640 1.00 7.31  ? 107  GLY A N   1 
ATOM   777  C  CA  . GLY A 1 130 ? -13.180 19.575  29.668 1.00 8.06  ? 107  GLY A CA  1 
ATOM   778  C  C   . GLY A 1 130 ? -14.300 18.559  29.851 1.00 8.95  ? 107  GLY A C   1 
ATOM   779  O  O   . GLY A 1 130 ? -14.059 17.353  30.021 1.00 8.29  ? 107  GLY A O   1 
ATOM   780  N  N   . GLU A 1 131 ? -15.543 19.059  29.861 1.00 10.14 ? 108  GLU A N   1 
ATOM   781  C  CA  . GLU A 1 131 ? -16.687 18.270  30.271 1.00 11.08 ? 108  GLU A CA  1 
ATOM   782  C  C   . GLU A 1 131 ? -16.956 17.065  29.373 1.00 10.39 ? 108  GLU A C   1 
ATOM   783  O  O   . GLU A 1 131 ? -17.539 16.096  29.868 1.00 11.85 ? 108  GLU A O   1 
ATOM   784  C  CB  . GLU A 1 131 ? -17.897 19.193  30.432 1.00 13.46 ? 108  GLU A CB  1 
ATOM   785  C  CG  . GLU A 1 131 ? -17.756 20.157  31.626 1.00 18.28 ? 108  GLU A CG  1 
ATOM   786  C  CD  . GLU A 1 131 ? -18.938 21.058  31.933 0.80 24.29 ? 108  GLU A CD  1 
ATOM   787  O  OE1 . GLU A 1 131 ? -18.808 21.889  32.858 0.80 27.71 ? 108  GLU A OE1 1 
ATOM   788  O  OE2 . GLU A 1 131 ? -19.983 20.917  31.257 0.80 29.89 ? 108  GLU A OE2 1 
ATOM   789  N  N   . ASP A 1 132 ? -16.554 17.119  28.099 1.00 9.84  ? 109  ASP A N   1 
ATOM   790  C  CA  . ASP A 1 132 ? -16.720 16.006  27.186 1.00 9.54  ? 109  ASP A CA  1 
ATOM   791  C  C   . ASP A 1 132 ? -15.519 15.049  27.212 1.00 8.95  ? 109  ASP A C   1 
ATOM   792  O  O   . ASP A 1 132 ? -15.450 14.176  26.355 1.00 8.65  ? 109  ASP A O   1 
ATOM   793  C  CB  . ASP A 1 132 ? -16.950 16.533  25.784 1.00 10.66 ? 109  ASP A CB  1 
ATOM   794  C  CG  . ASP A 1 132 ? -15.786 17.307  25.216 1.00 11.65 ? 109  ASP A CG  1 
ATOM   795  O  OD1 . ASP A 1 132 ? -14.786 17.500  25.941 1.00 10.51 ? 109  ASP A OD1 1 
ATOM   796  O  OD2 . ASP A 1 132 ? -15.867 17.678  24.011 1.00 16.29 ? 109  ASP A OD2 1 
ATOM   797  N  N   . TYR A 1 133 ? -14.626 15.228  28.188 1.00 7.92  ? 110  TYR A N   1 
ATOM   798  C  CA  . TYR A 1 133 ? -13.461 14.395  28.444 1.00 7.35  ? 110  TYR A CA  1 
ATOM   799  C  C   . TYR A 1 133 ? -12.332 14.658  27.459 1.00 6.92  ? 110  TYR A C   1 
ATOM   800  O  O   . TYR A 1 133 ? -11.315 13.956  27.495 1.00 6.91  ? 110  TYR A O   1 
ATOM   801  C  CB  . TYR A 1 133 ? -13.780 12.907  28.552 1.00 7.39  ? 110  TYR A CB  1 
ATOM   802  C  CG  . TYR A 1 133 ? -14.926 12.612  29.508 1.00 8.08  ? 110  TYR A CG  1 
ATOM   803  C  CD1 . TYR A 1 133 ? -14.895 13.008  30.820 1.00 8.83  ? 110  TYR A CD1 1 
ATOM   804  C  CD2 . TYR A 1 133 ? -16.071 11.993  29.044 1.00 9.16  ? 110  TYR A CD2 1 
ATOM   805  C  CE1 . TYR A 1 133 ? -15.949 12.734  31.679 1.00 10.24 ? 110  TYR A CE1 1 
ATOM   806  C  CE2 . TYR A 1 133 ? -17.147 11.742  29.868 1.00 11.12 ? 110  TYR A CE2 1 
ATOM   807  C  CZ  . TYR A 1 133 ? -17.066 12.106  31.175 1.00 10.71 ? 110  TYR A CZ  1 
ATOM   808  O  OH  . TYR A 1 133 ? -18.111 11.822  32.027 1.00 14.43 ? 110  TYR A OH  1 
ATOM   809  N  N   . ARG A 1 134 ? -12.446 15.712  26.666 1.00 7.37  ? 111  ARG A N   1 
ATOM   810  C  CA  . ARG A 1 134 ? -11.390 16.070  25.690 1.00 6.98  ? 111  ARG A CA  1 
ATOM   811  C  C   . ARG A 1 134 ? -10.609 17.311  26.148 1.00 6.66  ? 111  ARG A C   1 
ATOM   812  O  O   . ARG A 1 134 ? -11.121 18.119  26.916 1.00 7.31  ? 111  ARG A O   1 
ATOM   813  C  CB  . ARG A 1 134 ? -11.987 16.280  24.285 1.00 8.43  ? 111  ARG A CB  1 
ATOM   814  C  CG  . ARG A 1 134 ? -12.094 15.015  23.445 1.00 10.06 ? 111  ARG A CG  1 
ATOM   815  C  CD  . ARG A 1 134 ? -12.896 13.946  24.148 1.00 11.14 ? 111  ARG A CD  1 
ATOM   816  N  NE  . ARG A 1 134 ? -13.022 12.725  23.351 1.00 9.86  ? 111  ARG A NE  1 
ATOM   817  C  CZ  . ARG A 1 134 ? -13.861 11.759  23.659 1.00 9.50  ? 111  ARG A CZ  1 
ATOM   818  N  NH1 . ARG A 1 134 ? -14.683 11.890  24.682 1.00 9.91  ? 111  ARG A NH1 1 
ATOM   819  N  NH2 . ARG A 1 134 ? -13.887 10.664  22.930 1.00 9.72  ? 111  ARG A NH2 1 
ATOM   820  N  N   . TYR A 1 135 ? -9.389  17.412  25.656 1.00 6.98  ? 112  TYR A N   1 
ATOM   821  C  CA  . TYR A 1 135 ? -8.509  18.526  25.942 1.00 7.12  ? 112  TYR A CA  1 
ATOM   822  C  C   . TYR A 1 135 ? -9.179  19.824  25.516 1.00 7.25  ? 112  TYR A C   1 
ATOM   823  O  O   . TYR A 1 135 ? -9.716  19.916  24.423 1.00 8.21  ? 112  TYR A O   1 
ATOM   824  C  CB  . TYR A 1 135 ? -7.200  18.272  25.187 1.00 7.53  ? 112  TYR A CB  1 
ATOM   825  C  CG  . TYR A 1 135 ? -6.088  19.289  25.448 1.00 6.86  ? 112  TYR A CG  1 
ATOM   826  C  CD1 . TYR A 1 135 ? -6.130  20.567  24.896 1.00 6.82  ? 112  TYR A CD1 1 
ATOM   827  C  CD2 . TYR A 1 135 ? -5.024  18.943  26.263 1.00 7.11  ? 112  TYR A CD2 1 
ATOM   828  C  CE1 . TYR A 1 135 ? -5.151  21.473  25.182 1.00 7.32  ? 112  TYR A CE1 1 
ATOM   829  C  CE2 . TYR A 1 135 ? -4.027  19.839  26.552 1.00 7.40  ? 112  TYR A CE2 1 
ATOM   830  C  CZ  . TYR A 1 135 ? -4.089  21.115  26.008 1.00 7.17  ? 112  TYR A CZ  1 
ATOM   831  O  OH  . TYR A 1 135 ? -3.078  22.015  26.319 1.00 8.65  ? 112  TYR A OH  1 
ATOM   832  N  N   . ASP A 1 136 ? -8.985  20.850  26.322 1.00 7.53  ? 113  ASP A N   1 
ATOM   833  C  CA  . ASP A 1 136 ? -9.447  22.219  25.960 1.00 8.49  ? 113  ASP A CA  1 
ATOM   834  C  C   . ASP A 1 136 ? -8.429  23.214  26.538 1.00 8.16  ? 113  ASP A C   1 
ATOM   835  O  O   . ASP A 1 136 ? -8.344  23.318  27.753 1.00 7.99  ? 113  ASP A O   1 
ATOM   836  C  CB  . ASP A 1 136 ? -10.871 22.462  26.441 1.00 9.16  ? 113  ASP A CB  1 
ATOM   837  C  CG  . ASP A 1 136 ? -11.497 23.811  26.114 1.00 13.38 ? 113  ASP A CG  1 
ATOM   838  O  OD1 . ASP A 1 136 ? -10.763 24.789  25.996 1.00 12.69 ? 113  ASP A OD1 1 
ATOM   839  O  OD2 . ASP A 1 136 ? -12.728 23.867  26.032 1.00 17.63 ? 113  ASP A OD2 1 
ATOM   840  N  N   A GLU A 1 137 ? -7.729  23.940  25.668 0.70 8.18  ? 114  GLU A N   1 
ATOM   841  N  N   B GLU A 1 137 ? -7.733  23.941  25.663 0.30 8.27  ? 114  GLU A N   1 
ATOM   842  C  CA  A GLU A 1 137 ? -6.674  24.890  26.116 0.70 9.01  ? 114  GLU A CA  1 
ATOM   843  C  CA  B GLU A 1 137 ? -6.686  24.898  26.108 0.30 8.62  ? 114  GLU A CA  1 
ATOM   844  C  C   A GLU A 1 137 ? -7.272  26.019  26.994 0.70 9.10  ? 114  GLU A C   1 
ATOM   845  C  C   B GLU A 1 137 ? -7.309  26.015  26.969 0.30 8.56  ? 114  GLU A C   1 
ATOM   846  O  O   A GLU A 1 137 ? -6.581  26.492  27.889 0.70 10.33 ? 114  GLU A O   1 
ATOM   847  O  O   B GLU A 1 137 ? -6.617  26.498  27.881 0.30 9.19  ? 114  GLU A O   1 
ATOM   848  C  CB  A GLU A 1 137 ? -5.985  25.454  24.871 0.70 11.52 ? 114  GLU A CB  1 
ATOM   849  C  CB  B GLU A 1 137 ? -5.976  25.475  24.881 0.30 9.65  ? 114  GLU A CB  1 
ATOM   850  C  CG  A GLU A 1 137 ? -4.783  26.344  25.172 0.70 14.76 ? 114  GLU A CG  1 
ATOM   851  C  CG  B GLU A 1 137 ? -6.894  26.299  23.983 0.30 10.56 ? 114  GLU A CG  1 
ATOM   852  C  CD  A GLU A 1 137 ? -3.702  25.768  26.065 0.70 19.65 ? 114  GLU A CD  1 
ATOM   853  C  CD  B GLU A 1 137 ? -6.309  26.653  22.630 0.30 12.21 ? 114  GLU A CD  1 
ATOM   854  O  OE1 A GLU A 1 137 ? -3.083  24.734  25.703 0.70 17.49 ? 114  GLU A OE1 1 
ATOM   855  O  OE1 B GLU A 1 137 ? -5.263  27.332  22.602 0.30 13.52 ? 114  GLU A OE1 1 
ATOM   856  O  OE2 A GLU A 1 137 ? -3.490  26.391  27.130 0.70 26.71 ? 114  GLU A OE2 1 
ATOM   857  O  OE2 B GLU A 1 137 ? -6.900  26.247  21.608 0.30 15.51 ? 114  GLU A OE2 1 
ATOM   858  N  N   A GLU A 1 138 ? -8.530  26.386  26.750 0.70 8.65  ? 115  GLU A N   1 
ATOM   859  N  N   B GLU A 1 138 ? -8.562  26.389  26.690 0.30 8.16  ? 115  GLU A N   1 
ATOM   860  C  CA  A GLU A 1 138 ? -9.105  27.445  27.574 0.70 9.15  ? 115  GLU A CA  1 
ATOM   861  C  CA  B GLU A 1 138 ? -9.206  27.418  27.492 0.30 8.14  ? 115  GLU A CA  1 
ATOM   862  C  C   A GLU A 1 138 ? -9.470  26.950  28.971 0.70 8.33  ? 115  GLU A C   1 
ATOM   863  C  C   B GLU A 1 138 ? -9.399  26.932  28.925 0.30 7.87  ? 115  GLU A C   1 
ATOM   864  O  O   A GLU A 1 138 ? -9.249  27.638  29.983 0.70 8.55  ? 115  GLU A O   1 
ATOM   865  O  O   B GLU A 1 138 ? -8.996  27.629  29.871 0.30 7.69  ? 115  GLU A O   1 
ATOM   866  C  CB  A GLU A 1 138 ? -10.330 28.107  26.947 0.70 11.25 ? 115  GLU A CB  1 
ATOM   867  C  CB  B GLU A 1 138 ? -10.506 27.887  26.839 0.30 8.72  ? 115  GLU A CB  1 
ATOM   868  C  CG  A GLU A 1 138 ? -10.171 28.459  25.474 0.70 14.89 ? 115  GLU A CG  1 
ATOM   869  C  CG  B GLU A 1 138 ? -10.263 28.534  25.483 0.30 9.29  ? 115  GLU A CG  1 
ATOM   870  C  CD  A GLU A 1 138 ? -9.046  29.406  25.141 0.70 17.71 ? 115  GLU A CD  1 
ATOM   871  C  CD  B GLU A 1 138 ? -9.387  29.752  25.643 0.30 9.38  ? 115  GLU A CD  1 
ATOM   872  O  OE1 A GLU A 1 138 ? -8.828  29.609  23.940 0.70 22.21 ? 115  GLU A OE1 1 
ATOM   873  O  OE1 B GLU A 1 138 ? -8.182  29.695  25.264 0.30 9.48  ? 115  GLU A OE1 1 
ATOM   874  O  OE2 A GLU A 1 138 ? -8.379  29.944  26.058 0.70 20.75 ? 115  GLU A OE2 1 
ATOM   875  O  OE2 B GLU A 1 138 ? -9.919  30.728  26.232 0.30 9.47  ? 115  GLU A OE2 1 
ATOM   876  N  N   . VAL A 1 139 ? -9.955  25.716  29.049 1.00 8.06  ? 116  VAL A N   1 
ATOM   877  C  CA  . VAL A 1 139 ? -10.179 25.077  30.340 1.00 7.37  ? 116  VAL A CA  1 
ATOM   878  C  C   . VAL A 1 139 ? -8.881  24.888  31.119 1.00 7.01  ? 116  VAL A C   1 
ATOM   879  O  O   . VAL A 1 139 ? -8.822  25.160  32.329 1.00 7.44  ? 116  VAL A O   1 
ATOM   880  C  CB  . VAL A 1 139 ? -10.879 23.735  30.082 1.00 8.04  ? 116  VAL A CB  1 
ATOM   881  C  CG1 . VAL A 1 139 ? -10.861 22.847  31.336 1.00 8.45  ? 116  VAL A CG1 1 
ATOM   882  C  CG2 . VAL A 1 139 ? -12.303 23.971  29.612 1.00 8.77  ? 116  VAL A CG2 1 
ATOM   883  N  N   . LEU A 1 140 ? -7.802  24.530  30.421 1.00 6.92  ? 117  LEU A N   1 
ATOM   884  C  CA  . LEU A 1 140 ? -6.520  24.393  31.052 1.00 7.43  ? 117  LEU A CA  1 
ATOM   885  C  C   . LEU A 1 140 ? -6.152  25.682  31.783 1.00 6.78  ? 117  LEU A C   1 
ATOM   886  O  O   . LEU A 1 140 ? -5.683  25.658  32.922 1.00 7.37  ? 117  LEU A O   1 
ATOM   887  C  CB  . LEU A 1 140 ? -5.419  24.046  30.060 1.00 7.81  ? 117  LEU A CB  1 
ATOM   888  C  CG  . LEU A 1 140 ? -4.035  23.942  30.663 1.00 8.80  ? 117  LEU A CG  1 
ATOM   889  C  CD1 . LEU A 1 140 ? -3.968  22.883  31.760 1.00 9.16  ? 117  LEU A CD1 1 
ATOM   890  C  CD2 . LEU A 1 140 ? -3.012  23.657  29.589 1.00 11.17 ? 117  LEU A CD2 1 
ATOM   891  N  N   . LYS A 1 141 ? -6.268  26.807  31.081 1.00 7.04  ? 118  LYS A N   1 
ATOM   892  C  CA  . LYS A 1 141 ? -5.842  28.088  31.639 1.00 7.37  ? 118  LYS A CA  1 
ATOM   893  C  C   . LYS A 1 141 ? -6.668  28.458  32.868 1.00 6.70  ? 118  LYS A C   1 
ATOM   894  O  O   . LYS A 1 141 ? -6.125  28.889  33.896 1.00 7.75  ? 118  LYS A O   1 
ATOM   895  C  CB  . LYS A 1 141 ? -5.943  29.191  30.575 1.00 9.18  ? 118  LYS A CB  1 
ATOM   896  C  CG  . LYS A 1 141 ? -4.858  29.067  29.561 1.00 10.97 ? 118  LYS A CG  1 
ATOM   897  C  CD  . LYS A 1 141 ? -4.874  30.111  28.445 1.00 14.99 ? 118  LYS A CD  1 
ATOM   898  C  CE  . LYS A 1 141 ? -5.921  29.932  27.505 1.00 15.19 ? 118  LYS A CE  1 
ATOM   899  N  NZ  . LYS A 1 141 ? -5.814  30.820  26.297 1.00 14.76 ? 118  LYS A NZ  1 
ATOM   900  N  N   . VAL A 1 142 ? -7.977  28.231  32.809 1.00 6.79  ? 119  VAL A N   1 
ATOM   901  C  CA  . VAL A 1 142 ? -8.850  28.509  33.960 1.00 7.15  ? 119  VAL A CA  1 
ATOM   902  C  C   . VAL A 1 142 ? -8.438  27.643  35.135 1.00 7.00  ? 119  VAL A C   1 
ATOM   903  O  O   . VAL A 1 142 ? -8.302  28.104  36.280 1.00 7.41  ? 119  VAL A O   1 
ATOM   904  C  CB  . VAL A 1 142 ? -10.313 28.292  33.599 1.00 8.37  ? 119  VAL A CB  1 
ATOM   905  C  CG1 . VAL A 1 142 ? -11.223 28.277  34.829 1.00 8.99  ? 119  VAL A CG1 1 
ATOM   906  C  CG2 . VAL A 1 142 ? -10.774 29.356  32.632 1.00 9.08  ? 119  VAL A CG2 1 
ATOM   907  N  N   . ASN A 1 143 ? -8.233  26.329  34.872 1.00 6.59  ? 120  ASN A N   1 
ATOM   908  C  CA  . ASN A 1 143 ? -7.996  25.377  35.936 1.00 6.93  ? 120  ASN A CA  1 
ATOM   909  C  C   . ASN A 1 143 ? -6.645  25.620  36.574 1.00 7.28  ? 120  ASN A C   1 
ATOM   910  O  O   . ASN A 1 143 ? -6.480  25.476  37.785 1.00 7.78  ? 120  ASN A O   1 
ATOM   911  C  CB  . ASN A 1 143 ? -8.158  23.971  35.381 1.00 6.81  ? 120  ASN A CB  1 
ATOM   912  C  CG  . ASN A 1 143 ? -9.584  23.643  35.071 1.00 6.89  ? 120  ASN A CG  1 
ATOM   913  O  OD1 . ASN A 1 143 ? -10.523 24.382  35.370 1.00 7.42  ? 120  ASN A OD1 1 
ATOM   914  N  ND2 . ASN A 1 143 ? -9.796  22.508  34.432 1.00 7.03  ? 120  ASN A ND2 1 
ATOM   915  N  N   . GLN A 1 144 ? -5.605  25.914  35.783 1.00 7.45  ? 121  GLN A N   1 
ATOM   916  C  CA  . GLN A 1 144 ? -4.294  26.209  36.332 1.00 7.99  ? 121  GLN A CA  1 
ATOM   917  C  C   . GLN A 1 144 ? -4.321  27.491  37.175 1.00 8.64  ? 121  GLN A C   1 
ATOM   918  O  O   . GLN A 1 144 ? -3.666  27.551  38.215 1.00 9.70  ? 121  GLN A O   1 
ATOM   919  C  CB  . GLN A 1 144 ? -3.206  26.218  35.263 1.00 8.33  ? 121  GLN A CB  1 
ATOM   920  C  CG  . GLN A 1 144 ? -2.956  24.809  34.734 1.00 8.43  ? 121  GLN A CG  1 
ATOM   921  C  CD  . GLN A 1 144 ? -1.796  24.705  33.763 1.00 9.51  ? 121  GLN A CD  1 
ATOM   922  O  OE1 . GLN A 1 144 ? -1.616  25.570  32.898 1.00 11.37 ? 121  GLN A OE1 1 
ATOM   923  N  NE2 . GLN A 1 144 ? -1.057  23.628  33.858 1.00 9.13  ? 121  GLN A NE2 1 
ATOM   924  N  N   . GLU A 1 145 ? -5.079  28.490  36.768 1.00 7.55  ? 122  GLU A N   1 
ATOM   925  C  CA  A GLU A 1 145 ? -5.255  29.692  37.585 0.70 8.29  ? 122  GLU A CA  1 
ATOM   926  C  CA  B GLU A 1 145 ? -5.277  29.686  37.573 0.30 8.35  ? 122  GLU A CA  1 
ATOM   927  C  C   . GLU A 1 145 ? -5.994  29.336  38.871 1.00 8.80  ? 122  GLU A C   1 
ATOM   928  O  O   . GLU A 1 145 ? -5.657  29.856  39.930 1.00 9.99  ? 122  GLU A O   1 
ATOM   929  C  CB  A GLU A 1 145 ? -6.023  30.736  36.788 0.70 9.42  ? 122  GLU A CB  1 
ATOM   930  C  CB  B GLU A 1 145 ? -6.127  30.692  36.810 0.30 8.86  ? 122  GLU A CB  1 
ATOM   931  C  CG  A GLU A 1 145 ? -6.199  32.098  37.480 0.70 11.99 ? 122  GLU A CG  1 
ATOM   932  C  CG  B GLU A 1 145 ? -5.333  31.500  35.793 0.30 9.89  ? 122  GLU A CG  1 
ATOM   933  C  CD  A GLU A 1 145 ? -6.686  33.137  36.456 0.70 15.38 ? 122  GLU A CD  1 
ATOM   934  C  CD  B GLU A 1 145 ? -6.215  32.474  35.064 0.30 11.16 ? 122  GLU A CD  1 
ATOM   935  O  OE1 A GLU A 1 145 ? -5.917  34.124  36.265 0.70 20.60 ? 122  GLU A OE1 1 
ATOM   936  O  OE1 B GLU A 1 145 ? -7.414  32.134  34.830 0.30 11.22 ? 122  GLU A OE1 1 
ATOM   937  O  OE2 A GLU A 1 145 ? -7.724  33.006  35.810 0.70 19.33 ? 122  GLU A OE2 1 
ATOM   938  O  OE2 B GLU A 1 145 ? -5.657  33.540  34.703 0.30 13.93 ? 122  GLU A OE2 1 
ATOM   939  N  N   . ASN A 1 146 ? -7.016  28.481  38.791 1.00 8.19  ? 123  ASN A N   1 
ATOM   940  C  CA  . ASN A 1 146 ? -7.777  28.097  39.987 1.00 8.59  ? 123  ASN A CA  1 
ATOM   941  C  C   . ASN A 1 146 ? -6.962  27.260  40.944 1.00 9.37  ? 123  ASN A C   1 
ATOM   942  O  O   . ASN A 1 146 ? -7.204  27.369  42.170 1.00 11.37 ? 123  ASN A O   1 
ATOM   943  C  CB  . ASN A 1 146 ? -8.978  27.256  39.607 1.00 8.88  ? 123  ASN A CB  1 
ATOM   944  C  CG  . ASN A 1 146 ? -10.048 28.051  38.942 1.00 8.87  ? 123  ASN A CG  1 
ATOM   945  O  OD1 . ASN A 1 146 ? -10.020 29.296  38.918 1.00 8.62  ? 123  ASN A OD1 1 
ATOM   946  N  ND2 . ASN A 1 146 ? -11.072 27.400  38.396 1.00 9.66  ? 123  ASN A ND2 1 
ATOM   947  N  N   . GLY A 1 147 ? -6.076  26.399  40.477 1.00 9.34  ? 124  GLY A N   1 
ATOM   948  C  CA  . GLY A 1 147 ? -5.383  25.439  41.322 1.00 8.94  ? 124  GLY A CA  1 
ATOM   949  C  C   . GLY A 1 147 ? -6.161  24.155  41.570 1.00 9.23  ? 124  GLY A C   1 
ATOM   950  O  O   . GLY A 1 147 ? -5.890  23.481  42.581 1.00 9.52  ? 124  GLY A O   1 
ATOM   951  N  N   . TYR A 1 148 ? -7.066  23.773  40.662 1.00 8.15  ? 125  TYR A N   1 
ATOM   952  C  CA  . TYR A 1 148 ? -7.765  22.512  40.791 1.00 8.43  ? 125  TYR A CA  1 
ATOM   953  C  C   . TYR A 1 148 ? -8.378  22.217  39.426 1.00 8.62  ? 125  TYR A C   1 
ATOM   954  O  O   . TYR A 1 148 ? -8.723  23.118  38.638 1.00 7.79  ? 125  TYR A O   1 
ATOM   955  C  CB  . TYR A 1 148 ? -8.820  22.505  41.909 1.00 8.52  ? 125  TYR A CB  1 
ATOM   956  C  CG  . TYR A 1 148 ? -9.772  23.682  41.922 1.00 7.96  ? 125  TYR A CG  1 
ATOM   957  C  CD1 . TYR A 1 148 ? -10.967 23.694  41.242 1.00 9.23  ? 125  TYR A CD1 1 
ATOM   958  C  CD2 . TYR A 1 148 ? -9.453  24.824  42.659 1.00 8.11  ? 125  TYR A CD2 1 
ATOM   959  C  CE1 . TYR A 1 148 ? -11.816 24.790  41.285 1.00 9.15  ? 125  TYR A CE1 1 
ATOM   960  C  CE2 . TYR A 1 148 ? -10.284 25.916  42.692 1.00 8.91  ? 125  TYR A CE2 1 
ATOM   961  C  CZ  . TYR A 1 148 ? -11.486 25.919  42.035 1.00 8.78  ? 125  TYR A CZ  1 
ATOM   962  O  OH  . TYR A 1 148 ? -12.376 26.959  42.070 1.00 9.98  ? 125  TYR A OH  1 
ATOM   963  N  N   . PRO A 1 149 ? -8.606  20.918  39.112 1.00 8.22  ? 126  PRO A N   1 
ATOM   964  C  CA  . PRO A 1 149 ? -9.215  20.510  37.847 1.00 8.54  ? 126  PRO A CA  1 
ATOM   965  C  C   . PRO A 1 149 ? -10.696 20.764  37.882 1.00 9.43  ? 126  PRO A C   1 
ATOM   966  O  O   . PRO A 1 149 ? -11.238 20.942  38.985 1.00 10.50 ? 126  PRO A O   1 
ATOM   967  C  CB  . PRO A 1 149 ? -8.902  19.004  37.792 1.00 8.74  ? 126  PRO A CB  1 
ATOM   968  C  CG  . PRO A 1 149 ? -8.897  18.568  39.231 1.00 9.51  ? 126  PRO A CG  1 
ATOM   969  C  CD  . PRO A 1 149 ? -8.284  19.756  39.928 1.00 8.56  ? 126  PRO A CD  1 
ATOM   970  N  N   . SER A 1 150 ? -11.332 20.759  36.727 1.00 8.35  ? 127  SER A N   1 
ATOM   971  C  CA  . SER A 1 150 ? -12.765 20.891  36.619 1.00 8.25  ? 127  SER A CA  1 
ATOM   972  C  C   . SER A 1 150 ? -13.469 19.560  36.363 1.00 8.66  ? 127  SER A C   1 
ATOM   973  O  O   . SER A 1 150 ? -14.654 19.469  36.636 1.00 10.19 ? 127  SER A O   1 
ATOM   974  C  CB  . SER A 1 150 ? -13.118 21.912  35.558 1.00 8.99  ? 127  SER A CB  1 
ATOM   975  O  OG  . SER A 1 150 ? -12.558 21.535  34.302 1.00 8.83  ? 127  SER A OG  1 
ATOM   976  N  N   . VAL A 1 151 ? -12.777 18.572  35.816 1.00 7.84  ? 128  VAL A N   1 
ATOM   977  C  CA  . VAL A 1 151 ? -13.390 17.295  35.465 1.00 7.93  ? 128  VAL A CA  1 
ATOM   978  C  C   . VAL A 1 151 ? -12.478 16.177  35.894 1.00 8.14  ? 128  VAL A C   1 
ATOM   979  O  O   . VAL A 1 151 ? -11.281 16.212  35.619 1.00 8.95  ? 128  VAL A O   1 
ATOM   980  C  CB  . VAL A 1 151 ? -13.592 17.237  33.945 1.00 8.72  ? 128  VAL A CB  1 
ATOM   981  C  CG1 . VAL A 1 151 ? -14.118 15.881  33.494 1.00 9.72  ? 128  VAL A CG1 1 
ATOM   982  C  CG2 . VAL A 1 151 ? -14.466 18.383  33.461 1.00 9.57  ? 128  VAL A CG2 1 
ATOM   983  N  N   . THR A 1 152 ? -13.056 15.199  36.582 1.00 7.43  ? 129  THR A N   1 
ATOM   984  C  CA  . THR A 1 152 ? -12.353 14.004  36.978 1.00 8.64  ? 129  THR A CA  1 
ATOM   985  C  C   . THR A 1 152 ? -12.393 12.999  35.818 1.00 7.83  ? 129  THR A C   1 
ATOM   986  O  O   . THR A 1 152 ? -13.446 12.716  35.290 1.00 8.80  ? 129  THR A O   1 
ATOM   987  C  CB  . THR A 1 152 ? -13.040 13.366  38.195 1.00 10.24 ? 129  THR A CB  1 
ATOM   988  O  OG1 . THR A 1 152 ? -13.043 14.327  39.271 1.00 13.11 ? 129  THR A OG1 1 
ATOM   989  C  CG2 . THR A 1 152 ? -12.259 12.155  38.683 1.00 10.88 ? 129  THR A CG2 1 
ATOM   990  N  N   . ASN A 1 153 ? -11.238 12.503  35.402 1.00 7.10  ? 130  ASN A N   1 
ATOM   991  C  CA  . ASN A 1 153 ? -11.193 11.556  34.303 1.00 6.99  ? 130  ASN A CA  1 
ATOM   992  C  C   . ASN A 1 153 ? -11.789 10.217  34.764 1.00 7.72  ? 130  ASN A C   1 
ATOM   993  O  O   . ASN A 1 153 ? -11.238 9.582   35.657 1.00 8.92  ? 130  ASN A O   1 
ATOM   994  C  CB  . ASN A 1 153 ? -9.745  11.356  33.879 1.00 7.10  ? 130  ASN A CB  1 
ATOM   995  C  CG  . ASN A 1 153 ? -9.571  10.317  32.781 1.00 6.97  ? 130  ASN A CG  1 
ATOM   996  O  OD1 . ASN A 1 153 ? -10.504 10.083  31.982 1.00 6.51  ? 130  ASN A OD1 1 
ATOM   997  N  ND2 . ASN A 1 153 ? -8.377  9.734   32.695 1.00 6.83  ? 130  ASN A ND2 1 
ATOM   998  N  N   . PRO A 1 154 ? -12.862 9.728   34.129 1.00 8.00  ? 131  PRO A N   1 
ATOM   999  C  CA  . PRO A 1 154 ? -13.347 8.389   34.433 1.00 9.37  ? 131  PRO A CA  1 
ATOM   1000 C  C   . PRO A 1 154 ? -12.256 7.334   34.110 1.00 9.12  ? 131  PRO A C   1 
ATOM   1001 O  O   . PRO A 1 154 ? -12.310 6.244   34.589 1.00 14.02 ? 131  PRO A O   1 
ATOM   1002 C  CB  . PRO A 1 154 ? -14.586 8.289   33.489 1.00 9.05  ? 131  PRO A CB  1 
ATOM   1003 C  CG  . PRO A 1 154 ? -14.994 9.691   33.176 1.00 8.98  ? 131  PRO A CG  1 
ATOM   1004 C  CD  . PRO A 1 154 ? -13.663 10.401  33.143 1.00 7.93  ? 131  PRO A CD  1 
ATOM   1005 N  N   . GLY A 1 155 ? -11.411 7.569   33.089 1.00 9.57  ? 132  GLY A N   1 
ATOM   1006 C  CA  . GLY A 1 155 ? -10.425 6.569   32.663 1.00 10.17 ? 132  GLY A CA  1 
ATOM   1007 C  C   . GLY A 1 155 ? -11.027 5.550   31.693 1.00 10.41 ? 132  GLY A C   1 
ATOM   1008 O  O   . GLY A 1 155 ? -11.770 5.875   30.766 1.00 10.45 ? 132  GLY A O   1 
ATOM   1009 N  N   . SER A 1 156 ? -10.708 4.272   31.941 1.00 9.51  ? 133  SER A N   1 
ATOM   1010 C  CA  . SER A 1 156 ? -11.176 3.170   31.094 1.00 9.46  ? 133  SER A CA  1 
ATOM   1011 C  C   . SER A 1 156 ? -12.693 3.192   30.825 1.00 9.15  ? 133  SER A C   1 
ATOM   1012 O  O   . SER A 1 156 ? -13.514 3.435   31.729 1.00 9.30  ? 133  SER A O   1 
ATOM   1013 C  CB  . SER A 1 156 ? -10.777 1.845   31.691 1.00 10.40 ? 133  SER A CB  1 
ATOM   1014 O  OG  . SER A 1 156 ? -11.516 1.581   32.882 1.00 14.24 ? 133  SER A OG  1 
ATOM   1015 N  N   . GLY A 1 157 ? -13.061 2.733   29.676 1.00 9.84  ? 134  GLY A N   1 
ATOM   1016 C  CA  . GLY A 1 157 ? -14.474 2.471   29.393 1.00 9.88  ? 134  GLY A CA  1 
ATOM   1017 C  C   . GLY A 1 157 ? -15.019 3.411   28.382 1.00 11.84 ? 134  GLY A C   1 
ATOM   1018 O  O   . GLY A 1 157 ? -14.280 4.212   27.812 1.00 8.64  ? 134  GLY A O   1 
ATOM   1019 N  N   . THR A 1 158 ? -16.333 3.267   28.171 1.00 10.35 ? 135  THR A N   1 
ATOM   1020 C  CA  . THR A 1 158 ? -16.957 3.988   27.050 1.00 12.52 ? 135  THR A CA  1 
ATOM   1021 C  C   . THR A 1 158 ? -17.278 5.424   27.334 1.00 11.50 ? 135  THR A C   1 
ATOM   1022 O  O   . THR A 1 158 ? -17.579 6.156   26.353 1.00 13.33 ? 135  THR A O   1 
ATOM   1023 C  CB  . THR A 1 158 ? -18.197 3.237   26.573 1.00 13.16 ? 135  THR A CB  1 
ATOM   1024 O  OG1 . THR A 1 158 ? -19.105 3.050   27.663 1.00 14.80 ? 135  THR A OG1 1 
ATOM   1025 C  CG2 . THR A 1 158 ? -17.905 1.883   25.941 1.00 14.03 ? 135  THR A CG2 1 
ATOM   1026 N  N   . ALA A 1 159 ? -17.196 5.917   28.581 1.00 11.85 ? 136  ALA A N   1 
ATOM   1027 C  CA  . ALA A 1 159 ? -17.449 7.307   28.866 1.00 12.43 ? 136  ALA A CA  1 
ATOM   1028 C  C   . ALA A 1 159 ? -16.418 8.127   28.122 1.00 8.70  ? 136  ALA A C   1 
ATOM   1029 O  O   . ALA A 1 159 ? -16.736 9.092   27.427 1.00 11.30 ? 136  ALA A O   1 
ATOM   1030 C  CB  . ALA A 1 159 ? -17.415 7.606   30.350 1.00 11.58 ? 136  ALA A CB  1 
ATOM   1031 N  N   . THR A 1 160 ? -15.122 7.693   28.180 1.00 8.59  ? 137  THR A N   1 
ATOM   1032 C  CA  . THR A 1 160 ? -14.001 8.348   27.514 1.00 7.71  ? 137  THR A CA  1 
ATOM   1033 C  C   . THR A 1 160 ? -13.484 7.594   26.295 1.00 7.13  ? 137  THR A C   1 
ATOM   1034 O  O   . THR A 1 160 ? -12.650 8.129   25.572 1.00 7.71  ? 137  THR A O   1 
ATOM   1035 C  CB  . THR A 1 160 ? -12.812 8.560   28.450 1.00 7.48  ? 137  THR A CB  1 
ATOM   1036 O  OG1 . THR A 1 160 ? -12.209 7.283   28.659 1.00 7.16  ? 137  THR A OG1 1 
ATOM   1037 C  CG2 . THR A 1 160 ? -13.193 9.227   29.755 1.00 7.48  ? 137  THR A CG2 1 
ATOM   1038 N  N   . MET A 1 161 ? -13.999 6.370   26.067 1.00 7.31  ? 138  MET A N   1 
ATOM   1039 C  CA  . MET A 1 161 ? -13.437 5.453   25.017 1.00 6.77  ? 138  MET A CA  1 
ATOM   1040 C  C   . MET A 1 161 ? -11.961 5.175   25.339 1.00 6.40  ? 138  MET A C   1 
ATOM   1041 O  O   . MET A 1 161 ? -11.127 5.274   24.470 1.00 6.57  ? 138  MET A O   1 
ATOM   1042 C  CB  . MET A 1 161 ? -13.643 5.953   23.581 1.00 7.32  ? 138  MET A CB  1 
ATOM   1043 C  CG  . MET A 1 161 ? -15.111 6.233   23.273 1.00 7.78  ? 138  MET A CG  1 
ATOM   1044 S  SD  . MET A 1 161 ? -16.282 4.883   23.534 1.00 13.54 ? 138  MET A SD  1 
ATOM   1045 C  CE  . MET A 1 161 ? -15.469 3.674   22.497 1.00 7.00  ? 138  MET A CE  1 
ATOM   1046 N  N   . TRP A 1 162 ? -11.695 4.818   26.589 1.00 6.27  ? 139  TRP A N   1 
ATOM   1047 C  CA  . TRP A 1 162 ? -10.351 4.527   27.028 1.00 5.89  ? 139  TRP A CA  1 
ATOM   1048 C  C   . TRP A 1 162 ? -9.431  5.686   26.682 1.00 6.05  ? 139  TRP A C   1 
ATOM   1049 O  O   . TRP A 1 162 ? -8.271  5.492   26.278 1.00 6.29  ? 139  TRP A O   1 
ATOM   1050 C  CB  . TRP A 1 162 ? -9.835  3.179   26.500 1.00 6.62  ? 139  TRP A CB  1 
ATOM   1051 C  CG  . TRP A 1 162 ? -10.634 2.018   27.020 1.00 6.63  ? 139  TRP A CG  1 
ATOM   1052 C  CD1 . TRP A 1 162 ? -10.337 1.278   28.113 1.00 7.42  ? 139  TRP A CD1 1 
ATOM   1053 C  CD2 . TRP A 1 162 ? -11.896 1.526   26.535 1.00 6.42  ? 139  TRP A CD2 1 
ATOM   1054 N  NE1 . TRP A 1 162 ? -11.318 0.334   28.306 1.00 7.33  ? 139  TRP A NE1 1 
ATOM   1055 C  CE2 . TRP A 1 162 ? -12.274 0.454   27.358 1.00 7.25  ? 139  TRP A CE2 1 
ATOM   1056 C  CE3 . TRP A 1 162 ? -12.702 1.837   25.446 1.00 6.76  ? 139  TRP A CE3 1 
ATOM   1057 C  CZ2 . TRP A 1 162 ? -13.471 -0.239  27.180 1.00 7.21  ? 139  TRP A CZ2 1 
ATOM   1058 C  CZ3 . TRP A 1 162 ? -13.863 1.118   25.230 1.00 7.04  ? 139  TRP A CZ3 1 
ATOM   1059 C  CH2 . TRP A 1 162 ? -14.250 0.114   26.120 1.00 7.18  ? 139  TRP A CH2 1 
ATOM   1060 N  N   . ASN A 1 163 ? -9.927  6.902   26.906 1.00 5.69  ? 140  ASN A N   1 
ATOM   1061 C  CA  . ASN A 1 163 ? -9.117  8.138   26.672 1.00 5.48  ? 140  ASN A CA  1 
ATOM   1062 C  C   . ASN A 1 163 ? -8.557  8.193   25.245 1.00 5.19  ? 140  ASN A C   1 
ATOM   1063 O  O   . ASN A 1 163 ? -7.473  8.708   25.038 1.00 6.00  ? 140  ASN A O   1 
ATOM   1064 C  CB  . ASN A 1 163 ? -8.036  8.286   27.746 1.00 5.53  ? 140  ASN A CB  1 
ATOM   1065 C  CG  . ASN A 1 163 ? -8.607  8.527   29.128 1.00 6.16  ? 140  ASN A CG  1 
ATOM   1066 O  OD1 . ASN A 1 163 ? -8.271  7.809   30.072 1.00 8.09  ? 140  ASN A OD1 1 
ATOM   1067 N  ND2 . ASN A 1 163 ? -9.452  9.534   29.287 1.00 4.87  ? 140  ASN A ND2 1 
ATOM   1068 N  N   . ALA A 1 164 ? -9.347  7.726   24.297 1.00 5.06  ? 141  ALA A N   1 
ATOM   1069 C  CA  . ALA A 1 164 ? -8.898  7.633   22.921 1.00 5.50  ? 141  ALA A CA  1 
ATOM   1070 C  C   . ALA A 1 164 ? -8.530  8.989   22.364 1.00 5.95  ? 141  ALA A C   1 
ATOM   1071 O  O   . ALA A 1 164 ? -9.310  9.946   22.455 1.00 5.73  ? 141  ALA A O   1 
ATOM   1072 C  CB  . ALA A 1 164 ? -9.954  7.014   22.024 1.00 6.66  ? 141  ALA A CB  1 
ATOM   1073 N  N   . THR A 1 165 ? -7.435  9.040   21.615 1.00 5.66  ? 142  THR A N   1 
ATOM   1074 C  CA  . THR A 1 165 ? -7.068  10.240  20.862 1.00 5.87  ? 142  THR A CA  1 
ATOM   1075 C  C   . THR A 1 165 ? -8.122  10.586  19.820 1.00 6.02  ? 142  THR A C   1 
ATOM   1076 O  O   . THR A 1 165 ? -8.569  11.742  19.734 1.00 6.08  ? 142  THR A O   1 
ATOM   1077 C  CB  . THR A 1 165 ? -5.698  10.090  20.221 1.00 5.80  ? 142  THR A CB  1 
ATOM   1078 O  OG1 . THR A 1 165 ? -4.771  9.816   21.279 1.00 5.34  ? 142  THR A OG1 1 
ATOM   1079 C  CG2 . THR A 1 165 ? -5.273  11.276  19.386 1.00 6.16  ? 142  THR A CG2 1 
ATOM   1080 N  N   . VAL A 1 166 ? -8.462  9.592   18.990 1.00 5.88  ? 143  VAL A N   1 
ATOM   1081 C  CA  . VAL A 1 166 ? -9.469  9.734   17.949 1.00 5.81  ? 143  VAL A CA  1 
ATOM   1082 C  C   . VAL A 1 166 ? -10.582 8.761   18.245 1.00 5.71  ? 143  VAL A C   1 
ATOM   1083 O  O   . VAL A 1 166 ? -10.322 7.551   18.300 1.00 6.12  ? 143  VAL A O   1 
ATOM   1084 C  CB  . VAL A 1 166 ? -8.907  9.567   16.536 1.00 6.41  ? 143  VAL A CB  1 
ATOM   1085 C  CG1 . VAL A 1 166 ? -10.021 9.663   15.484 1.00 7.16  ? 143  VAL A CG1 1 
ATOM   1086 C  CG2 . VAL A 1 166 ? -7.830  10.618  16.294 1.00 6.52  ? 143  VAL A CG2 1 
ATOM   1087 N  N   . TYR A 1 167 ? -11.797 9.274   18.416 1.00 5.71  ? 144  TYR A N   1 
ATOM   1088 C  CA  . TYR A 1 167 ? -13.000 8.486   18.593 1.00 6.34  ? 144  TYR A CA  1 
ATOM   1089 C  C   . TYR A 1 167 ? -13.827 8.623   17.322 1.00 6.30  ? 144  TYR A C   1 
ATOM   1090 O  O   . TYR A 1 167 ? -14.251 9.764   17.007 1.00 6.72  ? 144  TYR A O   1 
ATOM   1091 C  CB  . TYR A 1 167 ? -13.754 8.981   19.813 1.00 6.48  ? 144  TYR A CB  1 
ATOM   1092 C  CG  . TYR A 1 167 ? -15.129 8.378   19.999 1.00 6.85  ? 144  TYR A CG  1 
ATOM   1093 C  CD1 . TYR A 1 167 ? -15.419 7.067   19.692 1.00 7.45  ? 144  TYR A CD1 1 
ATOM   1094 C  CD2 . TYR A 1 167 ? -16.161 9.117   20.528 1.00 7.83  ? 144  TYR A CD2 1 
ATOM   1095 C  CE1 . TYR A 1 167 ? -16.682 6.510   19.870 1.00 8.28  ? 144  TYR A CE1 1 
ATOM   1096 C  CE2 . TYR A 1 167 ? -17.412 8.574   20.746 1.00 9.44  ? 144  TYR A CE2 1 
ATOM   1097 C  CZ  . TYR A 1 167 ? -17.668 7.273   20.422 1.00 8.62  ? 144  TYR A CZ  1 
ATOM   1098 O  OH  . TYR A 1 167 ? -18.895 6.664   20.654 1.00 11.90 ? 144  TYR A OH  1 
ATOM   1099 N  N   . VAL A 1 168 ? -13.963 7.538   16.586 1.00 6.19  ? 145  VAL A N   1 
ATOM   1100 C  CA  . VAL A 1 168 ? -14.776 7.517   15.382 1.00 6.93  ? 145  VAL A CA  1 
ATOM   1101 C  C   . VAL A 1 168 ? -16.165 7.060   15.752 1.00 8.06  ? 145  VAL A C   1 
ATOM   1102 O  O   . VAL A 1 168 ? -16.344 5.930   16.205 1.00 7.99  ? 145  VAL A O   1 
ATOM   1103 C  CB  . VAL A 1 168 ? -14.158 6.624   14.300 1.00 7.82  ? 145  VAL A CB  1 
ATOM   1104 C  CG1 . VAL A 1 168 ? -15.055 6.548   13.046 1.00 8.84  ? 145  VAL A CG1 1 
ATOM   1105 C  CG2 . VAL A 1 168 ? -12.781 7.084   13.941 1.00 7.70  ? 145  VAL A CG2 1 
ATOM   1106 N  N   . ASN A 1 169 ? -17.164 7.925   15.531 1.00 8.08  ? 146  ASN A N   1 
ATOM   1107 C  CA  . ASN A 1 169 ? -18.548 7.638   15.859 1.00 8.67  ? 146  ASN A CA  1 
ATOM   1108 C  C   . ASN A 1 169 ? -19.457 8.046   14.709 1.00 9.03  ? 146  ASN A C   1 
ATOM   1109 O  O   . ASN A 1 169 ? -20.450 8.747   14.927 1.00 11.77 ? 146  ASN A O   1 
ATOM   1110 C  CB  . ASN A 1 169 ? -18.953 8.288   17.166 1.00 10.79 ? 146  ASN A CB  1 
ATOM   1111 C  CG  . ASN A 1 169 ? -20.168 7.619   17.725 1.00 13.88 ? 146  ASN A CG  1 
ATOM   1112 O  OD1 . ASN A 1 169 ? -20.370 6.406   17.507 1.00 16.12 ? 146  ASN A OD1 1 
ATOM   1113 N  ND2 . ASN A 1 169 ? -20.927 8.389   18.496 1.00 16.21 ? 146  ASN A ND2 1 
ATOM   1114 N  N   . ALA A 1 170 ? -19.104 7.622   13.519 1.00 8.15  ? 147  ALA A N   1 
ATOM   1115 C  CA  . ALA A 1 170 ? -19.873 7.937   12.326 1.00 8.61  ? 147  ALA A CA  1 
ATOM   1116 C  C   . ALA A 1 170 ? -19.597 6.883   11.272 1.00 8.34  ? 147  ALA A C   1 
ATOM   1117 O  O   . ALA A 1 170 ? -18.619 6.157   11.348 1.00 9.89  ? 147  ALA A O   1 
ATOM   1118 C  CB  . ALA A 1 170 ? -19.474 9.298   11.795 1.00 9.86  ? 147  ALA A CB  1 
ATOM   1119 N  N   . ASP A 1 171 ? -20.482 6.749   10.303 1.00 7.35  ? 148  ASP A N   1 
ATOM   1120 C  CA  . ASP A 1 171 ? -20.329 5.822   9.199  1.00 7.21  ? 148  ASP A CA  1 
ATOM   1121 C  C   . ASP A 1 171 ? -19.380 6.384   8.148  1.00 7.16  ? 148  ASP A C   1 
ATOM   1122 O  O   . ASP A 1 171 ? -19.205 7.597   8.033  1.00 7.60  ? 148  ASP A O   1 
ATOM   1123 C  CB  . ASP A 1 171 ? -21.666 5.549   8.517  1.00 8.19  ? 148  ASP A CB  1 
ATOM   1124 C  CG  . ASP A 1 171 ? -22.624 4.753   9.354  1.00 10.88 ? 148  ASP A CG  1 
ATOM   1125 O  OD1 . ASP A 1 171 ? -22.220 3.961   10.213 1.00 10.01 ? 148  ASP A OD1 1 
ATOM   1126 O  OD2 . ASP A 1 171 ? -23.867 4.936   9.153  1.00 15.91 ? 148  ASP A OD2 1 
ATOM   1127 N  N   . GLY A 1 172 ? -18.744 5.469   7.405  1.00 6.99  ? 149  GLY A N   1 
ATOM   1128 C  CA  . GLY A 1 172 ? -18.054 5.858   6.209  1.00 6.83  ? 149  GLY A CA  1 
ATOM   1129 C  C   . GLY A 1 172 ? -16.733 6.571   6.447  1.00 7.42  ? 149  GLY A C   1 
ATOM   1130 O  O   . GLY A 1 172 ? -16.185 7.205   5.544  1.00 8.28  ? 149  GLY A O   1 
ATOM   1131 N  N   . PHE A 1 173 ? -16.185 6.496   7.657  1.00 7.00  ? 150  PHE A N   1 
ATOM   1132 C  CA  . PHE A 1 173 ? -14.916 7.105   7.980  1.00 6.90  ? 150  PHE A CA  1 
ATOM   1133 C  C   . PHE A 1 173 ? -13.765 6.366   7.310  1.00 6.88  ? 150  PHE A C   1 
ATOM   1134 O  O   . PHE A 1 173 ? -13.702 5.142   7.350  1.00 7.04  ? 150  PHE A O   1 
ATOM   1135 C  CB  . PHE A 1 173 ? -14.693 7.064   9.480  1.00 7.06  ? 150  PHE A CB  1 
ATOM   1136 C  CG  . PHE A 1 173 ? -13.395 7.750   9.862  1.00 6.90  ? 150  PHE A CG  1 
ATOM   1137 C  CD1 . PHE A 1 173 ? -13.293 9.109   9.797  1.00 7.18  ? 150  PHE A CD1 1 
ATOM   1138 C  CD2 . PHE A 1 173 ? -12.285 7.012   10.254 1.00 7.06  ? 150  PHE A CD2 1 
ATOM   1139 C  CE1 . PHE A 1 173 ? -12.094 9.743   10.101 1.00 8.09  ? 150  PHE A CE1 1 
ATOM   1140 C  CE2 . PHE A 1 173 ? -11.092 7.649   10.517 1.00 7.52  ? 150  PHE A CE2 1 
ATOM   1141 C  CZ  . PHE A 1 173 ? -10.992 8.993   10.490 1.00 7.61  ? 150  PHE A CZ  1 
ATOM   1142 N  N   . GLU A 1 174 ? -12.874 7.138   6.682  1.00 7.38  ? 151  GLU A N   1 
ATOM   1143 C  CA  . GLU A 1 174 ? -11.703 6.570   6.063  1.00 7.81  ? 151  GLU A CA  1 
ATOM   1144 C  C   . GLU A 1 174 ? -10.483 7.371   6.455  1.00 7.17  ? 151  GLU A C   1 
ATOM   1145 O  O   . GLU A 1 174 ? -10.558 8.589   6.704  1.00 7.37  ? 151  GLU A O   1 
ATOM   1146 C  CB  . GLU A 1 174 ? -11.829 6.612   4.537  1.00 8.57  ? 151  GLU A CB  1 
ATOM   1147 C  CG  . GLU A 1 174 ? -13.001 5.780   4.034  1.00 9.84  ? 151  GLU A CG  1 
ATOM   1148 C  CD  . GLU A 1 174 ? -13.250 5.824   2.539  1.00 12.12 ? 151  GLU A CD  1 
ATOM   1149 O  OE1 . GLU A 1 174 ? -14.283 5.256   2.104  1.00 13.76 ? 151  GLU A OE1 1 
ATOM   1150 O  OE2 . GLU A 1 174 ? -12.504 6.517   1.814  1.00 15.94 ? 151  GLU A OE2 1 
ATOM   1151 N  N   . ALA A 1 175 ? -9.317  6.710   6.500  1.00 6.91  ? 152  ALA A N   1 
ATOM   1152 C  CA  . ALA A 1 175 ? -8.075  7.420   6.739  1.00 7.29  ? 152  ALA A CA  1 
ATOM   1153 C  C   . ALA A 1 175 ? -6.963  6.756   5.956  1.00 6.70  ? 152  ALA A C   1 
ATOM   1154 O  O   . ALA A 1 175 ? -6.978  5.553   5.748  1.00 7.46  ? 152  ALA A O   1 
ATOM   1155 C  CB  . ALA A 1 175 ? -7.714  7.455   8.209  1.00 7.36  ? 152  ALA A CB  1 
ATOM   1156 N  N   . GLU A 1 176 ? -6.010  7.570   5.505  1.00 7.67  ? 153  GLU A N   1 
ATOM   1157 C  CA  . GLU A 1 176 ? -4.924  7.095   4.677  1.00 8.29  ? 153  GLU A CA  1 
ATOM   1158 C  C   . GLU A 1 176 ? -3.625  7.806   5.053  1.00 7.20  ? 153  GLU A C   1 
ATOM   1159 O  O   . GLU A 1 176 ? -3.534  9.025   5.093  1.00 7.41  ? 153  GLU A O   1 
ATOM   1160 C  CB  . GLU A 1 176 ? -5.166  7.357   3.187  1.00 10.45 ? 153  GLU A CB  1 
ATOM   1161 C  CG  . GLU A 1 176 ? -4.205  6.615   2.277  1.00 15.36 ? 153  GLU A CG  1 
ATOM   1162 C  CD  . GLU A 1 176 ? -4.658  6.465   0.834  0.50 18.68 ? 153  GLU A CD  1 
ATOM   1163 O  OE1 . GLU A 1 176 ? -4.018  5.612   0.198  0.50 24.88 ? 153  GLU A OE1 1 
ATOM   1164 O  OE2 . GLU A 1 176 ? -5.600  7.162   0.363  0.50 21.11 ? 153  GLU A OE2 1 
ATOM   1165 N  N   . GLY A 1 177 ? -2.608  6.994   5.392  1.00 6.61  ? 154  GLY A N   1 
ATOM   1166 C  CA  . GLY A 1 177 ? -1.292  7.535   5.643  1.00 6.99  ? 154  GLY A CA  1 
ATOM   1167 C  C   . GLY A 1 177 ? -1.162  8.322   6.943  1.00 6.80  ? 154  GLY A C   1 
ATOM   1168 O  O   . GLY A 1 177 ? -0.298  9.193   7.048  1.00 7.06  ? 154  GLY A O   1 
ATOM   1169 N  N   . ILE A 1 178 ? -1.969  7.971   7.966  1.00 7.12  ? 155  ILE A N   1 
ATOM   1170 C  CA  . ILE A 1 178 ? -2.011  8.683   9.237  1.00 6.73  ? 155  ILE A CA  1 
ATOM   1171 C  C   . ILE A 1 178 ? -1.458  7.803   10.347 1.00 6.42  ? 155  ILE A C   1 
ATOM   1172 O  O   . ILE A 1 178 ? -1.735  6.601   10.370 1.00 6.74  ? 155  ILE A O   1 
ATOM   1173 C  CB  . ILE A 1 178 ? -3.462  9.044   9.572  1.00 6.93  ? 155  ILE A CB  1 
ATOM   1174 C  CG1 . ILE A 1 178 ? -4.207  9.770   8.427  1.00 8.51  ? 155  ILE A CG1 1 
ATOM   1175 C  CG2 . ILE A 1 178 ? -3.520  9.804   10.902 1.00 6.95  ? 155  ILE A CG2 1 
ATOM   1176 C  CD1 . ILE A 1 178 ? -3.632  11.106  8.103  1.00 9.63  ? 155  ILE A CD1 1 
ATOM   1177 N  N   . ILE A 1 179 ? -0.674  8.390   11.249 1.00 6.25  ? 156  ILE A N   1 
ATOM   1178 C  CA  . ILE A 1 179 ? -0.298  7.755   12.510 1.00 6.22  ? 156  ILE A CA  1 
ATOM   1179 C  C   . ILE A 1 179 ? -1.241  8.265   13.594 1.00 6.38  ? 156  ILE A C   1 
ATOM   1180 O  O   . ILE A 1 179 ? -1.268  9.461   13.895 1.00 6.58  ? 156  ILE A O   1 
ATOM   1181 C  CB  . ILE A 1 179 ? 1.133   8.116   12.932 1.00 6.26  ? 156  ILE A CB  1 
ATOM   1182 C  CG1 . ILE A 1 179 ? 2.167   7.774   11.851 1.00 6.36  ? 156  ILE A CG1 1 
ATOM   1183 C  CG2 . ILE A 1 179 ? 1.461   7.431   14.265 1.00 6.29  ? 156  ILE A CG2 1 
ATOM   1184 C  CD1 . ILE A 1 179 ? 3.546   8.311   12.119 1.00 6.94  ? 156  ILE A CD1 1 
ATOM   1185 N  N   . PHE A 1 180 ? -2.033  7.385   14.191 1.00 5.73  ? 157  PHE A N   1 
ATOM   1186 C  CA  . PHE A 1 180 ? -2.867  7.656   15.349 1.00 5.73  ? 157  PHE A CA  1 
ATOM   1187 C  C   . PHE A 1 180 ? -2.109  7.188   16.574 1.00 5.60  ? 157  PHE A C   1 
ATOM   1188 O  O   . PHE A 1 180 ? -1.649  6.038   16.583 1.00 6.41  ? 157  PHE A O   1 
ATOM   1189 C  CB  . PHE A 1 180 ? -4.174  6.861   15.269 1.00 5.81  ? 157  PHE A CB  1 
ATOM   1190 C  CG  . PHE A 1 180 ? -5.018  7.244   14.050 1.00 6.13  ? 157  PHE A CG  1 
ATOM   1191 C  CD1 . PHE A 1 180 ? -5.965  8.267   14.135 1.00 6.65  ? 157  PHE A CD1 1 
ATOM   1192 C  CD2 . PHE A 1 180 ? -4.894  6.555   12.841 1.00 6.43  ? 157  PHE A CD2 1 
ATOM   1193 C  CE1 . PHE A 1 180 ? -6.741  8.607   13.021 1.00 6.59  ? 157  PHE A CE1 1 
ATOM   1194 C  CE2 . PHE A 1 180 ? -5.669  6.905   11.765 1.00 6.90  ? 157  PHE A CE2 1 
ATOM   1195 C  CZ  . PHE A 1 180 ? -6.592  7.924   11.873 1.00 6.86  ? 157  PHE A CZ  1 
ATOM   1196 N  N   . GLU A 1 181 ? -2.005  8.062   17.566 1.00 5.09  ? 158  GLU A N   1 
ATOM   1197 C  CA  . GLU A 1 181 ? -1.190  7.698   18.729 1.00 5.32  ? 158  GLU A CA  1 
ATOM   1198 C  C   . GLU A 1 181 ? -1.752  8.173   20.051 1.00 5.28  ? 158  GLU A C   1 
ATOM   1199 O  O   . GLU A 1 181 ? -2.357  9.230   20.084 1.00 5.45  ? 158  GLU A O   1 
ATOM   1200 C  CB  . GLU A 1 181 ? 0.160   8.408   18.562 1.00 5.77  ? 158  GLU A CB  1 
ATOM   1201 C  CG  . GLU A 1 181 ? 1.137   8.240   19.726 1.00 5.63  ? 158  GLU A CG  1 
ATOM   1202 C  CD  . GLU A 1 181 ? 2.421   9.027   19.501 1.00 6.31  ? 158  GLU A CD  1 
ATOM   1203 O  OE1 . GLU A 1 181 ? 2.462   10.213  19.867 1.00 6.86  ? 158  GLU A OE1 1 
ATOM   1204 O  OE2 . GLU A 1 181 ? 3.356   8.468   18.910 1.00 6.80  ? 158  GLU A OE2 1 
ATOM   1205 N  N   . ASN A 1 182 ? -1.601  7.335   21.074 1.00 4.96  ? 159  ASN A N   1 
ATOM   1206 C  CA  . ASN A 1 182 ? -1.723  7.817   22.438 1.00 5.31  ? 159  ASN A CA  1 
ATOM   1207 C  C   . ASN A 1 182 ? -0.324  7.730   23.022 1.00 5.32  ? 159  ASN A C   1 
ATOM   1208 O  O   . ASN A 1 182 ? 0.293   6.669   23.007 1.00 5.41  ? 159  ASN A O   1 
ATOM   1209 C  CB  . ASN A 1 182 ? -2.747  7.046   23.249 1.00 5.18  ? 159  ASN A CB  1 
ATOM   1210 C  CG  . ASN A 1 182 ? -3.045  7.716   24.571 1.00 5.46  ? 159  ASN A CG  1 
ATOM   1211 O  OD1 . ASN A 1 182 ? -2.123  8.132   25.270 1.00 5.89  ? 159  ASN A OD1 1 
ATOM   1212 N  ND2 . ASN A 1 182 ? -4.319  7.885   24.900 1.00 5.31  ? 159  ASN A ND2 1 
ATOM   1213 N  N   . SER A 1 183 ? 0.221   8.861   23.461 1.00 5.02  ? 160  SER A N   1 
ATOM   1214 C  CA  . SER A 1 183 ? 1.593   8.939   23.964 1.00 5.59  ? 160  SER A CA  1 
ATOM   1215 C  C   . SER A 1 183 ? 1.724   8.521   25.433 1.00 5.79  ? 160  SER A C   1 
ATOM   1216 O  O   . SER A 1 183 ? 2.848   8.559   25.960 1.00 5.77  ? 160  SER A O   1 
ATOM   1217 C  CB  . SER A 1 183 ? 2.197   10.281  23.739 1.00 6.31  ? 160  SER A CB  1 
ATOM   1218 O  OG  . SER A 1 183 ? 1.471   11.276  24.450 1.00 6.81  ? 160  SER A OG  1 
ATOM   1219 N  N   . PHE A 1 184 ? 0.630   8.146   26.087 1.00 5.38  ? 161  PHE A N   1 
ATOM   1220 C  CA  . PHE A 1 184 ? 0.656   7.873   27.561 1.00 5.55  ? 161  PHE A CA  1 
ATOM   1221 C  C   . PHE A 1 184 ? 1.837   6.993   27.961 1.00 5.54  ? 161  PHE A C   1 
ATOM   1222 O  O   . PHE A 1 184 ? 2.491   7.323   28.930 1.00 6.06  ? 161  PHE A O   1 
ATOM   1223 C  CB  . PHE A 1 184 ? -0.698  7.236   27.889 1.00 5.82  ? 161  PHE A CB  1 
ATOM   1224 C  CG  . PHE A 1 184 ? -0.992  7.000   29.362 1.00 5.37  ? 161  PHE A CG  1 
ATOM   1225 C  CD1 . PHE A 1 184 ? -1.268  8.067   30.206 1.00 6.05  ? 161  PHE A CD1 1 
ATOM   1226 C  CD2 . PHE A 1 184 ? -1.045  5.714   29.883 1.00 5.93  ? 161  PHE A CD2 1 
ATOM   1227 C  CE1 . PHE A 1 184 ? -1.574  7.851   31.539 1.00 6.34  ? 161  PHE A CE1 1 
ATOM   1228 C  CE2 . PHE A 1 184 ? -1.347  5.507   31.218 1.00 6.44  ? 161  PHE A CE2 1 
ATOM   1229 C  CZ  . PHE A 1 184 ? -1.615  6.573   32.042 1.00 6.41  ? 161  PHE A CZ  1 
ATOM   1230 N  N   . ASN A 1 185 ? 2.059   5.916   27.213 1.00 5.00  ? 162  ASN A N   1 
ATOM   1231 C  CA  . ASN A 1 185 ? 3.211   5.020   27.511 1.00 5.30  ? 162  ASN A CA  1 
ATOM   1232 C  C   . ASN A 1 185 ? 4.228   5.031   26.368 1.00 5.40  ? 162  ASN A C   1 
ATOM   1233 O  O   . ASN A 1 185 ? 4.897   4.036   26.179 1.00 5.85  ? 162  ASN A O   1 
ATOM   1234 C  CB  . ASN A 1 185 ? 2.738   3.625   27.882 1.00 5.50  ? 162  ASN A CB  1 
ATOM   1235 C  CG  . ASN A 1 185 ? 1.963   3.596   29.175 1.00 5.69  ? 162  ASN A CG  1 
ATOM   1236 O  OD1 . ASN A 1 185 ? 0.859   3.054   29.224 1.00 7.72  ? 162  ASN A OD1 1 
ATOM   1237 N  ND2 . ASN A 1 185 ? 2.535   4.142   30.233 1.00 4.17  ? 162  ASN A ND2 1 
ATOM   1238 N  N   . GLN A 1 186 ? 4.364   6.166   25.694 1.00 5.30  ? 163  GLN A N   1 
ATOM   1239 C  CA  . GLN A 1 186 ? 5.413   6.331   24.698 1.00 5.65  ? 163  GLN A CA  1 
ATOM   1240 C  C   . GLN A 1 186 ? 6.366   7.457   25.078 1.00 5.76  ? 163  GLN A C   1 
ATOM   1241 O  O   . GLN A 1 186 ? 7.595   7.234   25.036 1.00 6.41  ? 163  GLN A O   1 
ATOM   1242 C  CB  . GLN A 1 186 ? 4.859   6.557   23.300 1.00 5.84  ? 163  GLN A CB  1 
ATOM   1243 C  CG  . GLN A 1 186 ? 4.280   5.291   22.672 1.00 6.55  ? 163  GLN A CG  1 
ATOM   1244 C  CD  . GLN A 1 186 ? 5.365   4.310   22.308 1.00 6.94  ? 163  GLN A CD  1 
ATOM   1245 O  OE1 . GLN A 1 186 ? 5.535   3.255   22.966 1.00 7.62  ? 163  GLN A OE1 1 
ATOM   1246 N  NE2 . GLN A 1 186 ? 6.135   4.635   21.288 1.00 7.97  ? 163  GLN A NE2 1 
ATOM   1247 N  N   . TYR A 1 187 ? 5.881   8.636   25.444 1.00 5.83  ? 164  TYR A N   1 
ATOM   1248 C  CA  . TYR A 1 187 ? 6.785   9.783   25.762 1.00 5.51  ? 164  TYR A CA  1 
ATOM   1249 C  C   . TYR A 1 187 ? 5.939   10.898  26.344 1.00 6.24  ? 164  TYR A C   1 
ATOM   1250 O  O   . TYR A 1 187 ? 4.731   10.918  26.160 1.00 6.62  ? 164  TYR A O   1 
ATOM   1251 C  CB  . TYR A 1 187 ? 7.604   10.316  24.567 1.00 6.36  ? 164  TYR A CB  1 
ATOM   1252 C  CG  . TYR A 1 187 ? 6.687   10.830  23.468 1.00 6.26  ? 164  TYR A CG  1 
ATOM   1253 C  CD1 . TYR A 1 187 ? 6.099   9.962   22.556 1.00 6.49  ? 164  TYR A CD1 1 
ATOM   1254 C  CD2 . TYR A 1 187 ? 6.362   12.177  23.388 1.00 6.90  ? 164  TYR A CD2 1 
ATOM   1255 C  CE1 . TYR A 1 187 ? 5.229   10.419  21.583 1.00 6.39  ? 164  TYR A CE1 1 
ATOM   1256 C  CE2 . TYR A 1 187 ? 5.494   12.649  22.420 1.00 6.85  ? 164  TYR A CE2 1 
ATOM   1257 C  CZ  . TYR A 1 187 ? 4.926   11.766  21.520 1.00 6.86  ? 164  TYR A CZ  1 
ATOM   1258 O  OH  . TYR A 1 187 ? 4.064   12.237  20.583 1.00 7.71  ? 164  TYR A OH  1 
ATOM   1259 N  N   . VAL A 1 188 ? 6.593   11.791  27.059 1.00 6.10  ? 165  VAL A N   1 
ATOM   1260 C  CA  . VAL A 1 188 ? 5.908   12.971  27.582 1.00 6.46  ? 165  VAL A CA  1 
ATOM   1261 C  C   . VAL A 1 188 ? 5.867   14.039  26.510 1.00 6.79  ? 165  VAL A C   1 
ATOM   1262 O  O   . VAL A 1 188 ? 6.903   14.577  26.091 1.00 7.57  ? 165  VAL A O   1 
ATOM   1263 C  CB  . VAL A 1 188 ? 6.597   13.437  28.876 1.00 7.21  ? 165  VAL A CB  1 
ATOM   1264 C  CG1 . VAL A 1 188 ? 5.983   14.766  29.367 1.00 7.35  ? 165  VAL A CG1 1 
ATOM   1265 C  CG2 . VAL A 1 188 ? 6.528   12.373  29.926 1.00 7.42  ? 165  VAL A CG2 1 
ATOM   1266 N  N   . SER A 1 189 ? 4.678   14.311  26.020 1.00 6.63  ? 166  SER A N   1 
ATOM   1267 C  CA  . SER A 1 189 ? 4.537   15.305  24.962 1.00 7.10  ? 166  SER A CA  1 
ATOM   1268 C  C   . SER A 1 189 ? 4.689   16.724  25.512 1.00 7.63  ? 166  SER A C   1 
ATOM   1269 O  O   . SER A 1 189 ? 4.645   16.967  26.726 1.00 7.60  ? 166  SER A O   1 
ATOM   1270 C  CB  . SER A 1 189 ? 3.205   15.157  24.262 1.00 7.35  ? 166  SER A CB  1 
ATOM   1271 O  OG  . SER A 1 189 ? 2.157   15.566  25.163 1.00 7.40  ? 166  SER A OG  1 
ATOM   1272 N  N   . GLU A 1 190 ? 4.823   17.655  24.581 1.00 7.62  ? 167  GLU A N   1 
ATOM   1273 C  CA  . GLU A 1 190 ? 4.833   19.082  24.890 1.00 8.51  ? 167  GLU A CA  1 
ATOM   1274 C  C   . GLU A 1 190 ? 3.618   19.448  25.725 1.00 7.58  ? 167  GLU A C   1 
ATOM   1275 O  O   . GLU A 1 190 ? 3.731   20.113  26.758 1.00 8.20  ? 167  GLU A O   1 
ATOM   1276 C  CB  . GLU A 1 190 ? 4.895   19.855  23.569 1.00 9.42  ? 167  GLU A CB  1 
ATOM   1277 C  CG  . GLU A 1 190 ? 4.845   21.372  23.726 1.00 11.83 ? 167  GLU A CG  1 
ATOM   1278 C  CD  . GLU A 1 190 ? 4.647   22.067  22.381 1.00 14.14 ? 167  GLU A CD  1 
ATOM   1279 O  OE1 . GLU A 1 190 ? 4.606   23.323  22.383 1.00 20.50 ? 167  GLU A OE1 1 
ATOM   1280 O  OE2 . GLU A 1 190 ? 4.490   21.441  21.320 1.00 14.09 ? 167  GLU A OE2 1 
ATOM   1281 N  N   . LEU A 1 191 ? 2.429   19.126  25.242 1.00 7.03  ? 168  LEU A N   1 
ATOM   1282 C  CA  . LEU A 1 191 ? 1.222   19.500  25.956 1.00 7.04  ? 168  LEU A CA  1 
ATOM   1283 C  C   . LEU A 1 191 ? 1.146   18.801  27.302 1.00 7.27  ? 168  LEU A C   1 
ATOM   1284 O  O   . LEU A 1 191 ? 0.687   19.383  28.294 1.00 7.96  ? 168  LEU A O   1 
ATOM   1285 C  CB  . LEU A 1 191 ? -0.030  19.244  25.144 1.00 7.14  ? 168  LEU A CB  1 
ATOM   1286 C  CG  . LEU A 1 191 ? -0.217  20.143  23.912 1.00 8.27  ? 168  LEU A CG  1 
ATOM   1287 C  CD1 . LEU A 1 191 ? -1.571  19.907  23.302 1.00 8.10  ? 168  LEU A CD1 1 
ATOM   1288 C  CD2 . LEU A 1 191 ? -0.041  21.644  24.196 1.00 9.42  ? 168  LEU A CD2 1 
ATOM   1289 N  N   . ALA A 1 192 ? 1.540   17.529  27.398 1.00 6.83  ? 169  ALA A N   1 
ATOM   1290 C  CA  . ALA A 1 192 ? 1.476   16.850  28.690 1.00 6.96  ? 169  ALA A CA  1 
ATOM   1291 C  C   . ALA A 1 192 ? 2.365   17.530  29.727 1.00 7.31  ? 169  ALA A C   1 
ATOM   1292 O  O   . ALA A 1 192 ? 1.977   17.702  30.901 1.00 7.61  ? 169  ALA A O   1 
ATOM   1293 C  CB  . ALA A 1 192 ? 1.876   15.393  28.550 1.00 6.38  ? 169  ALA A CB  1 
ATOM   1294 N  N   . ALA A 1 193 ? 3.567   17.927  29.321 1.00 7.36  ? 170  ALA A N   1 
ATOM   1295 C  CA  . ALA A 1 193 ? 4.498   18.560  30.250 1.00 8.13  ? 170  ALA A CA  1 
ATOM   1296 C  C   . ALA A 1 193 ? 3.958   19.883  30.762 1.00 8.37  ? 170  ALA A C   1 
ATOM   1297 O  O   . ALA A 1 193 ? 4.227   20.237  31.887 1.00 9.30  ? 170  ALA A O   1 
ATOM   1298 C  CB  . ALA A 1 193 ? 5.825   18.782  29.597 1.00 8.49  ? 170  ALA A CB  1 
ATOM   1299 N  N   . GLU A 1 194 ? 3.191   20.587  29.943 1.00 7.92  ? 171  GLU A N   1 
ATOM   1300 C  CA  . GLU A 1 194 ? 2.605   21.885  30.321 1.00 8.60  ? 171  GLU A CA  1 
ATOM   1301 C  C   . GLU A 1 194 ? 1.308   21.745  31.113 1.00 8.76  ? 171  GLU A C   1 
ATOM   1302 O  O   . GLU A 1 194 ? 0.870   22.697  31.757 1.00 9.21  ? 171  GLU A O   1 
ATOM   1303 C  CB  . GLU A 1 194 ? 2.363   22.696  29.051 1.00 8.95  ? 171  GLU A CB  1 
ATOM   1304 C  CG  . GLU A 1 194 ? 3.664   23.178  28.408 1.00 11.29 ? 171  GLU A CG  1 
ATOM   1305 C  CD  . GLU A 1 194 ? 3.503   23.786  27.054 1.00 15.72 ? 171  GLU A CD  1 
ATOM   1306 O  OE1 . GLU A 1 194 ? 4.602   24.178  26.562 1.00 19.66 ? 171  GLU A OE1 1 
ATOM   1307 O  OE2 . GLU A 1 194 ? 2.418   23.811  26.444 1.00 16.69 ? 171  GLU A OE2 1 
ATOM   1308 N  N   . ASP A 1 195 ? 0.639   20.583  31.053 1.00 6.94  ? 172  ASP A N   1 
ATOM   1309 C  CA  . ASP A 1 195 ? -0.591  20.303  31.754 1.00 7.14  ? 172  ASP A CA  1 
ATOM   1310 C  C   . ASP A 1 195 ? -0.279  20.124  33.235 1.00 7.39  ? 172  ASP A C   1 
ATOM   1311 O  O   . ASP A 1 195 ? 0.879   20.015  33.628 1.00 8.61  ? 172  ASP A O   1 
ATOM   1312 C  CB  . ASP A 1 195 ? -1.220  19.071  31.124 1.00 7.21  ? 172  ASP A CB  1 
ATOM   1313 C  CG  . ASP A 1 195 ? -2.710  18.868  31.316 1.00 6.91  ? 172  ASP A CG  1 
ATOM   1314 O  OD1 . ASP A 1 195 ? -3.358  19.516  32.164 1.00 7.55  ? 172  ASP A OD1 1 
ATOM   1315 O  OD2 . ASP A 1 195 ? -3.246  17.965  30.581 1.00 7.80  ? 172  ASP A OD2 1 
ATOM   1316 N  N   . THR A 1 196 ? -1.327  20.047  34.053 1.00 7.20  ? 173  THR A N   1 
ATOM   1317 C  CA  . THR A 1 196 ? -1.189  19.582  35.418 1.00 7.78  ? 173  THR A CA  1 
ATOM   1318 C  C   . THR A 1 196 ? -1.920  18.243  35.484 1.00 7.80  ? 173  THR A C   1 
ATOM   1319 O  O   . THR A 1 196 ? -3.121  18.146  35.217 1.00 7.73  ? 173  THR A O   1 
ATOM   1320 C  CB  . THR A 1 196 ? -1.731  20.598  36.414 1.00 8.38  ? 173  THR A CB  1 
ATOM   1321 O  OG1 . THR A 1 196 ? -1.067  21.841  36.214 1.00 9.47  ? 173  THR A OG1 1 
ATOM   1322 C  CG2 . THR A 1 196 ? -1.488  20.110  37.829 1.00 8.52  ? 173  THR A CG2 1 
ATOM   1323 N  N   . ILE A 1 197 ? -1.163  17.214  35.820 1.00 7.60  ? 174  ILE A N   1 
ATOM   1324 C  CA  . ILE A 1 197 ? -1.584  15.823  35.781 1.00 7.83  ? 174  ILE A CA  1 
ATOM   1325 C  C   . ILE A 1 197 ? -1.651  15.353  37.216 1.00 8.96  ? 174  ILE A C   1 
ATOM   1326 O  O   . ILE A 1 197 ? -0.678  15.516  37.954 1.00 11.00 ? 174  ILE A O   1 
ATOM   1327 C  CB  . ILE A 1 197 ? -0.590  15.001  34.962 1.00 7.87  ? 174  ILE A CB  1 
ATOM   1328 C  CG1 . ILE A 1 197 ? -0.370  15.578  33.555 1.00 8.83  ? 174  ILE A CG1 1 
ATOM   1329 C  CG2 . ILE A 1 197 ? -1.020  13.531  34.958 1.00 8.75  ? 174  ILE A CG2 1 
ATOM   1330 C  CD1 . ILE A 1 197 ? 0.659   14.871  32.705 1.00 9.65  ? 174  ILE A CD1 1 
ATOM   1331 N  N   . VAL A 1 198 ? -2.773  14.806  37.641 1.00 8.18  ? 175  VAL A N   1 
ATOM   1332 C  CA  . VAL A 1 198 ? -3.061  14.413  39.020 1.00 8.38  ? 175  VAL A CA  1 
ATOM   1333 C  C   . VAL A 1 198 ? -3.231  12.893  39.092 1.00 7.76  ? 175  VAL A C   1 
ATOM   1334 O  O   . VAL A 1 198 ? -4.154  12.322  38.479 1.00 7.53  ? 175  VAL A O   1 
ATOM   1335 C  CB  . VAL A 1 198 ? -4.349  15.101  39.500 1.00 9.17  ? 175  VAL A CB  1 
ATOM   1336 C  CG1 . VAL A 1 198 ? -4.642  14.748  40.945 1.00 11.04 ? 175  VAL A CG1 1 
ATOM   1337 C  CG2 . VAL A 1 198 ? -4.340  16.605  39.310 1.00 9.96  ? 175  VAL A CG2 1 
ATOM   1338 N  N   . ALA A 1 199 ? -2.369  12.214  39.847 1.00 7.37  ? 176  ALA A N   1 
ATOM   1339 C  CA  . ALA A 1 199 ? -2.550  10.791  40.101 1.00 7.81  ? 176  ALA A CA  1 
ATOM   1340 C  C   . ALA A 1 199 ? -3.814  10.564  40.895 1.00 7.86  ? 176  ALA A C   1 
ATOM   1341 O  O   . ALA A 1 199 ? -4.018  11.201  41.927 1.00 9.23  ? 176  ALA A O   1 
ATOM   1342 C  CB  . ALA A 1 199 ? -1.349  10.252  40.849 1.00 8.78  ? 176  ALA A CB  1 
ATOM   1343 N  N   . MET A 1 200 ? -4.649  9.639   40.418 1.00 7.47  ? 177  MET A N   1 
ATOM   1344 C  CA  . MET A 1 200 ? -5.914  9.299   41.019 1.00 7.17  ? 177  MET A CA  1 
ATOM   1345 C  C   . MET A 1 200 ? -5.990  7.771   41.217 1.00 7.01  ? 177  MET A C   1 
ATOM   1346 O  O   . MET A 1 200 ? -4.965  7.096   41.220 1.00 8.44  ? 177  MET A O   1 
ATOM   1347 C  CB  . MET A 1 200 ? -7.065  9.872   40.201 1.00 7.66  ? 177  MET A CB  1 
ATOM   1348 C  CG  . MET A 1 200 ? -7.036  11.399  40.123 1.00 7.32  ? 177  MET A CG  1 
ATOM   1349 S  SD  . MET A 1 200 ? -7.533  12.256  41.629 1.00 10.51 ? 177  MET A SD  1 
ATOM   1350 C  CE  . MET A 1 200 ? -9.305  11.959  41.594 1.00 12.26 ? 177  MET A CE  1 
ATOM   1351 N  N   . GLU A 1 201 ? -7.207  7.268   41.397 1.00 7.20  ? 178  GLU A N   1 
ATOM   1352 C  CA  . GLU A 1 201 ? -7.426  5.865   41.656 1.00 7.48  ? 178  GLU A CA  1 
ATOM   1353 C  C   . GLU A 1 201 ? -6.920  5.079   40.450 1.00 8.13  ? 178  GLU A C   1 
ATOM   1354 O  O   . GLU A 1 201 ? -7.289  5.376   39.304 1.00 8.77  ? 178  GLU A O   1 
ATOM   1355 C  CB  . GLU A 1 201 ? -8.894  5.586   41.892 1.00 7.70  ? 178  GLU A CB  1 
ATOM   1356 C  CG  . GLU A 1 201 ? -9.459  6.194   43.169 1.00 7.58  ? 178  GLU A CG  1 
ATOM   1357 C  CD  . GLU A 1 201 ? -9.707  7.687   43.165 1.00 7.76  ? 178  GLU A CD  1 
ATOM   1358 O  OE1 . GLU A 1 201 ? -9.801  8.305   42.104 1.00 7.92  ? 178  GLU A OE1 1 
ATOM   1359 O  OE2 . GLU A 1 201 ? -9.820  8.299   44.279 1.00 7.96  ? 178  GLU A OE2 1 
ATOM   1360 N  N   . GLY A 1 202 ? -6.113  4.074   40.701 1.00 8.30  ? 179  GLY A N   1 
ATOM   1361 C  CA  . GLY A 1 202 ? -5.661  3.219   39.601 1.00 9.00  ? 179  GLY A CA  1 
ATOM   1362 C  C   . GLY A 1 202 ? -4.395  3.723   38.929 1.00 9.25  ? 179  GLY A C   1 
ATOM   1363 O  O   . GLY A 1 202 ? -3.882  3.041   38.041 1.00 9.43  ? 179  GLY A O   1 
ATOM   1364 N  N   . ALA A 1 203 ? -3.790  4.851   39.341 1.00 7.60  ? 180  ALA A N   1 
ATOM   1365 C  CA  . ALA A 1 203 ? -2.558  5.314   38.735 1.00 7.60  ? 180  ALA A CA  1 
ATOM   1366 C  C   . ALA A 1 203 ? -1.470  4.276   38.949 1.00 8.09  ? 180  ALA A C   1 
ATOM   1367 O  O   . ALA A 1 203 ? -1.237  3.807   40.064 1.00 9.24  ? 180  ALA A O   1 
ATOM   1368 C  CB  . ALA A 1 203 ? -2.097  6.637   39.332 1.00 8.11  ? 180  ALA A CB  1 
ATOM   1369 N  N   . LYS A 1 204 ? -0.713  3.981   37.914 1.00 7.64  ? 181  LYS A N   1 
ATOM   1370 C  CA  . LYS A 1 204 ? 0.435   3.081   37.957 1.00 8.66  ? 181  LYS A CA  1 
ATOM   1371 C  C   . LYS A 1 204 ? 1.691   3.877   37.708 1.00 9.37  ? 181  LYS A C   1 
ATOM   1372 O  O   . LYS A 1 204 ? 1.827   4.455   36.617 1.00 9.21  ? 181  LYS A O   1 
ATOM   1373 C  CB  . LYS A 1 204 ? 0.333   1.975   36.921 1.00 10.61 ? 181  LYS A CB  1 
ATOM   1374 C  CG  . LYS A 1 204 ? -0.745  1.011   37.216 1.00 13.22 ? 181  LYS A CG  1 
ATOM   1375 C  CD  . LYS A 1 204 ? -0.457  0.149   38.440 1.00 18.55 ? 181  LYS A CD  1 
ATOM   1376 C  CE  . LYS A 1 204 ? -1.046  -1.230  38.393 1.00 22.50 ? 181  LYS A CE  1 
ATOM   1377 N  NZ  . LYS A 1 204 ? -2.444  -1.225  38.821 1.00 23.52 ? 181  LYS A NZ  1 
ATOM   1378 N  N   . GLU A 1 205 ? 2.647   3.832   38.637 1.00 8.62  ? 182  GLU A N   1 
ATOM   1379 C  CA  . GLU A 1 205 ? 3.905   4.524   38.428 1.00 9.66  ? 182  GLU A CA  1 
ATOM   1380 C  C   . GLU A 1 205 ? 5.041   3.669   38.963 1.00 9.94  ? 182  GLU A C   1 
ATOM   1381 O  O   . GLU A 1 205 ? 4.888   2.969   39.945 1.00 11.11 ? 182  GLU A O   1 
ATOM   1382 C  CB  . GLU A 1 205 ? 3.932   5.839   39.170 1.00 10.17 ? 182  GLU A CB  1 
ATOM   1383 C  CG  . GLU A 1 205 ? 2.848   6.752   38.595 1.00 11.92 ? 182  GLU A CG  1 
ATOM   1384 C  CD  . GLU A 1 205 ? 2.911   8.181   39.060 1.00 11.84 ? 182  GLU A CD  1 
ATOM   1385 O  OE1 . GLU A 1 205 ? 2.481   9.072   38.301 1.00 12.26 ? 182  GLU A OE1 1 
ATOM   1386 O  OE2 . GLU A 1 205 ? 3.384   8.446   40.177 1.00 13.74 ? 182  GLU A OE2 1 
ATOM   1387 N  N   . GLY A 1 206 ? 6.201   3.817   38.328 1.00 9.96  ? 183  GLY A N   1 
ATOM   1388 C  CA  . GLY A 1 206 ? 7.414   3.176   38.783 1.00 11.14 ? 183  GLY A CA  1 
ATOM   1389 C  C   . GLY A 1 206 ? 8.226   4.144   39.642 1.00 12.26 ? 183  GLY A C   1 
ATOM   1390 O  O   . GLY A 1 206 ? 7.689   4.906   40.433 1.00 12.90 ? 183  GLY A O   1 
ATOM   1391 N  N   . SER A 1 207 ? 9.545   4.064   39.490 1.00 11.93 ? 184  SER A N   1 
ATOM   1392 C  CA  . SER A 1 207 ? 10.452  4.683   40.450 1.00 13.62 ? 184  SER A CA  1 
ATOM   1393 C  C   . SER A 1 207 ? 11.204  5.859   39.843 1.00 14.11 ? 184  SER A C   1 
ATOM   1394 O  O   . SER A 1 207 ? 12.175  6.338   40.428 1.00 16.70 ? 184  SER A O   1 
ATOM   1395 C  CB  . SER A 1 207 ? 11.370  3.637   41.055 1.00 16.65 ? 184  SER A CB  1 
ATOM   1396 O  OG  . SER A 1 207 ? 12.074  2.908   40.089 1.00 21.39 ? 184  SER A OG  1 
ATOM   1397 N  N   . ASP A 1 208 ? 10.791  6.357   38.682 1.00 11.60 ? 185  ASP A N   1 
ATOM   1398 C  CA  . ASP A 1 208 ? 11.533  7.437   37.974 1.00 12.64 ? 185  ASP A CA  1 
ATOM   1399 C  C   . ASP A 1 208 ? 10.814  8.794   38.055 1.00 12.27 ? 185  ASP A C   1 
ATOM   1400 O  O   . ASP A 1 208 ? 11.141  9.684   37.289 1.00 16.59 ? 185  ASP A O   1 
ATOM   1401 C  CB  . ASP A 1 208 ? 11.797  7.000   36.548 1.00 13.88 ? 185  ASP A CB  1 
ATOM   1402 C  CG  . ASP A 1 208 ? 12.675  5.765   36.460 1.00 18.33 ? 185  ASP A CG  1 
ATOM   1403 O  OD1 . ASP A 1 208 ? 13.731  5.771   37.109 1.00 20.21 ? 185  ASP A OD1 1 
ATOM   1404 O  OD2 . ASP A 1 208 ? 12.274  4.802   35.797 1.00 21.30 ? 185  ASP A OD2 1 
ATOM   1405 N  N   . GLY A 1 209 ? 9.889   8.926   38.982 1.00 12.19 ? 186  GLY A N   1 
ATOM   1406 C  CA  . GLY A 1 209 ? 9.183   10.179  39.122 1.00 12.74 ? 186  GLY A CA  1 
ATOM   1407 C  C   . GLY A 1 209 ? 7.700   10.031  38.843 1.00 11.62 ? 186  GLY A C   1 
ATOM   1408 O  O   . GLY A 1 209 ? 7.276   9.132   38.099 1.00 12.53 ? 186  GLY A O   1 
ATOM   1409 N  N   . THR A 1 210 ? 6.892   10.894  39.431 1.00 11.11 ? 187  THR A N   1 
ATOM   1410 C  CA  A THR A 1 210 ? 5.470   10.877  39.147 0.70 10.78 ? 187  THR A CA  1 
ATOM   1411 C  CA  B THR A 1 210 ? 5.463   10.923  39.165 0.30 11.22 ? 187  THR A CA  1 
ATOM   1412 C  C   . THR A 1 210 ? 5.260   11.498  37.767 1.00 10.37 ? 187  THR A C   1 
ATOM   1413 O  O   . THR A 1 210 ? 6.042   12.293  37.258 1.00 11.63 ? 187  THR A O   1 
ATOM   1414 C  CB  A THR A 1 210 ? 4.688   11.622  40.230 0.70 11.21 ? 187  THR A CB  1 
ATOM   1415 C  CB  B THR A 1 210 ? 4.689   11.734  40.214 0.30 11.91 ? 187  THR A CB  1 
ATOM   1416 O  OG1 A THR A 1 210 ? 3.334   11.143  40.227 0.70 12.92 ? 187  THR A OG1 1 
ATOM   1417 O  OG1 B THR A 1 210 ? 5.103   11.370  41.526 0.30 13.37 ? 187  THR A OG1 1 
ATOM   1418 C  CG2 A THR A 1 210 ? 4.880   13.114  40.026 0.70 10.99 ? 187  THR A CG2 1 
ATOM   1419 C  CG2 B THR A 1 210 ? 3.191   11.469  40.189 0.30 12.09 ? 187  THR A CG2 1 
ATOM   1420 N  N   . ARG A 1 211 ? 4.142   11.103  37.119 1.00 10.43 ? 188  ARG A N   1 
ATOM   1421 C  CA  . ARG A 1 211 ? 3.898   11.522  35.736 1.00 9.91  ? 188  ARG A CA  1 
ATOM   1422 C  C   . ARG A 1 211 ? 3.934   13.040  35.572 1.00 10.02 ? 188  ARG A C   1 
ATOM   1423 O  O   . ARG A 1 211 ? 4.454   13.568  34.589 1.00 10.27 ? 188  ARG A O   1 
ATOM   1424 C  CB  . ARG A 1 211 ? 2.573   10.896  35.308 1.00 9.60  ? 188  ARG A CB  1 
ATOM   1425 C  CG  . ARG A 1 211 ? 2.215   11.163  33.862 1.00 9.32  ? 188  ARG A CG  1 
ATOM   1426 C  CD  . ARG A 1 211 ? 1.007   10.267  33.442 1.00 9.35  ? 188  ARG A CD  1 
ATOM   1427 N  NE  . ARG A 1 211 ? 1.337   8.863   33.211 1.00 7.73  ? 188  ARG A NE  1 
ATOM   1428 C  CZ  . ARG A 1 211 ? 1.730   8.353   32.035 1.00 6.52  ? 188  ARG A CZ  1 
ATOM   1429 N  NH1 . ARG A 1 211 ? 2.019   9.141   31.034 1.00 6.81  ? 188  ARG A NH1 1 
ATOM   1430 N  NH2 . ARG A 1 211 ? 1.882   7.055   31.878 1.00 6.41  ? 188  ARG A NH2 1 
ATOM   1431 N  N   . ASN A 1 212 ? 3.383   13.785  36.543 1.00 9.74  ? 189  ASN A N   1 
ATOM   1432 C  CA  . ASN A 1 212 ? 3.312   15.219  36.453 1.00 9.67  ? 189  ASN A CA  1 
ATOM   1433 C  C   . ASN A 1 212 ? 4.693   15.861  36.464 1.00 10.33 ? 189  ASN A C   1 
ATOM   1434 O  O   . ASN A 1 212 ? 4.819   16.993  36.032 1.00 11.10 ? 189  ASN A O   1 
ATOM   1435 C  CB  . ASN A 1 212 ? 2.451   15.789  37.572 1.00 9.72  ? 189  ASN A CB  1 
ATOM   1436 C  CG  . ASN A 1 212 ? 2.120   17.223  37.350 1.00 11.35 ? 189  ASN A CG  1 
ATOM   1437 O  OD1 . ASN A 1 212 ? 1.650   17.586  36.253 1.00 10.94 ? 189  ASN A OD1 1 
ATOM   1438 N  ND2 . ASN A 1 212 ? 2.368   18.067  38.331 1.00 13.75 ? 189  ASN A ND2 1 
ATOM   1439 N  N   . ASP A 1 213 ? 5.680   15.186  37.073 1.00 9.78  ? 190  ASP A N   1 
ATOM   1440 C  CA  . ASP A 1 213 ? 7.001   15.767  37.258 1.00 9.54  ? 190  ASP A CA  1 
ATOM   1441 C  C   . ASP A 1 213 ? 7.933   15.503  36.093 1.00 11.07 ? 190  ASP A C   1 
ATOM   1442 O  O   . ASP A 1 213 ? 9.003   16.109  36.000 1.00 11.68 ? 190  ASP A O   1 
ATOM   1443 C  CB  . ASP A 1 213 ? 7.633   15.343  38.566 1.00 9.51  ? 190  ASP A CB  1 
ATOM   1444 C  CG  . ASP A 1 213 ? 6.967   15.896  39.831 1.00 11.12 ? 190  ASP A CG  1 
ATOM   1445 O  OD1 . ASP A 1 213 ? 6.203   16.868  39.691 1.00 13.91 ? 190  ASP A OD1 1 
ATOM   1446 O  OD2 . ASP A 1 213 ? 7.182   15.310  40.924 1.00 12.48 ? 190  ASP A OD2 1 
ATOM   1447 N  N   . LEU A 1 214 ? 7.548   14.604  35.190 1.00 9.49  ? 191  LEU A N   1 
ATOM   1448 C  CA  . LEU A 1 214 ? 8.404   14.246  34.058 1.00 9.89  ? 191  LEU A CA  1 
ATOM   1449 C  C   . LEU A 1 214 ? 8.460   15.396  33.064 1.00 9.97  ? 191  LEU A C   1 
ATOM   1450 O  O   . LEU A 1 214 ? 7.478   16.077  32.794 1.00 11.39 ? 191  LEU A O   1 
ATOM   1451 C  CB  . LEU A 1 214 ? 7.888   12.951  33.391 1.00 10.12 ? 191  LEU A CB  1 
ATOM   1452 C  CG  . LEU A 1 214 ? 7.864   11.745  34.315 1.00 11.36 ? 191  LEU A CG  1 
ATOM   1453 C  CD1 . LEU A 1 214 ? 7.250   10.542  33.601 1.00 11.96 ? 191  LEU A CD1 1 
ATOM   1454 C  CD2 . LEU A 1 214 ? 9.217   11.407  34.896 1.00 12.53 ? 191  LEU A CD2 1 
ATOM   1455 N  N   A GLU A 1 215 ? 9.629   15.618  32.491 0.80 10.44 ? 192  GLU A N   1 
ATOM   1456 N  N   B GLU A 1 215 ? 9.657   15.592  32.501 0.20 10.02 ? 192  GLU A N   1 
ATOM   1457 C  CA  A GLU A 1 215 ? 9.831   16.697  31.548 0.80 11.56 ? 192  GLU A CA  1 
ATOM   1458 C  CA  B GLU A 1 215 ? 9.932   16.660  31.555 0.20 10.03 ? 192  GLU A CA  1 
ATOM   1459 C  C   A GLU A 1 215 ? 9.525   16.221  30.134 0.80 9.75  ? 192  GLU A C   1 
ATOM   1460 C  C   B GLU A 1 215 ? 9.538   16.215  30.147 0.20 9.75  ? 192  GLU A C   1 
ATOM   1461 O  O   A GLU A 1 215 ? 9.567   15.028  29.805 0.80 9.05  ? 192  GLU A O   1 
ATOM   1462 O  O   B GLU A 1 215 ? 9.518   15.020  29.856 0.20 9.61  ? 192  GLU A O   1 
ATOM   1463 C  CB  A GLU A 1 215 ? 11.250  17.251  31.627 0.80 15.31 ? 192  GLU A CB  1 
ATOM   1464 C  CB  B GLU A 1 215 ? 11.420  17.015  31.569 0.20 10.43 ? 192  GLU A CB  1 
ATOM   1465 C  CG  A GLU A 1 215 ? 11.495  17.797  33.034 0.80 19.99 ? 192  GLU A CG  1 
ATOM   1466 C  CG  B GLU A 1 215 ? 11.926  17.508  32.928 0.20 10.97 ? 192  GLU A CG  1 
ATOM   1467 C  CD  A GLU A 1 215 ? 12.796  18.525  33.293 0.80 26.67 ? 192  GLU A CD  1 
ATOM   1468 C  CD  B GLU A 1 215 ? 11.298  18.788  33.474 0.20 11.85 ? 192  GLU A CD  1 
ATOM   1469 O  OE1 A GLU A 1 215 ? 13.122  18.667  34.491 0.80 32.69 ? 192  GLU A OE1 1 
ATOM   1470 O  OE1 B GLU A 1 215 ? 10.591  19.508  32.746 0.20 13.17 ? 192  GLU A OE1 1 
ATOM   1471 O  OE2 A GLU A 1 215 ? 13.459  18.948  32.335 0.80 32.56 ? 192  GLU A OE2 1 
ATOM   1472 O  OE2 B GLU A 1 215 ? 11.537  19.073  34.663 0.20 13.84 ? 192  GLU A OE2 1 
ATOM   1473 N  N   . LYS A 1 216 ? 9.252   17.195  29.280 1.00 9.76  ? 193  LYS A N   1 
ATOM   1474 C  CA  . LYS A 1 216 ? 8.988   16.982  27.881 1.00 10.35 ? 193  LYS A CA  1 
ATOM   1475 C  C   . LYS A 1 216 ? 10.062  16.090  27.287 1.00 10.00 ? 193  LYS A C   1 
ATOM   1476 O  O   . LYS A 1 216 ? 11.259  16.331  27.426 1.00 9.72  ? 193  LYS A O   1 
ATOM   1477 C  CB  . LYS A 1 216 ? 8.966   18.331  27.131 1.00 11.74 ? 193  LYS A CB  1 
ATOM   1478 C  CG  . LYS A 1 216 ? 8.751   18.231  25.670 1.00 14.11 ? 193  LYS A CG  1 
ATOM   1479 C  CD  . LYS A 1 216 ? 8.679   19.624  25.023 1.00 16.59 ? 193  LYS A CD  1 
ATOM   1480 C  CE  . LYS A 1 216 ? 8.697   19.584  23.548 0.70 19.32 ? 193  LYS A CE  1 
ATOM   1481 N  NZ  . LYS A 1 216 ? 10.006  19.155  23.054 0.70 22.09 ? 193  LYS A NZ  1 
ATOM   1482 N  N   . GLY A 1 217 ? 9.637   15.082  26.546 1.00 8.77  ? 194  GLY A N   1 
ATOM   1483 C  CA  . GLY A 1 217 ? 10.529  14.190  25.840 1.00 8.83  ? 194  GLY A CA  1 
ATOM   1484 C  C   . GLY A 1 217 ? 10.916  12.960  26.645 1.00 9.56  ? 194  GLY A C   1 
ATOM   1485 O  O   . GLY A 1 217 ? 11.528  12.036  26.120 1.00 10.18 ? 194  GLY A O   1 
ATOM   1486 N  N   . SER A 1 218 ? 10.566  12.903  27.923 1.00 8.05  ? 195  SER A N   1 
ATOM   1487 C  CA  . SER A 1 218 ? 10.928  11.733  28.719 1.00 7.74  ? 195  SER A CA  1 
ATOM   1488 C  C   . SER A 1 218 ? 10.274  10.496  28.120 1.00 7.53  ? 195  SER A C   1 
ATOM   1489 O  O   . SER A 1 218 ? 9.062   10.498  27.860 1.00 8.01  ? 195  SER A O   1 
ATOM   1490 C  CB  . SER A 1 218 ? 10.510  11.900  30.157 1.00 7.98  ? 195  SER A CB  1 
ATOM   1491 O  OG  . SER A 1 218 ? 10.712  10.720  30.900 1.00 8.73  ? 195  SER A OG  1 
ATOM   1492 N  N   . THR A 1 219 ? 11.007  9.381   28.089 1.00 7.38  ? 196  THR A N   1 
ATOM   1493 C  CA  . THR A 1 219 ? 10.515  8.083   27.673 1.00 7.64  ? 196  THR A CA  1 
ATOM   1494 C  C   . THR A 1 219 ? 10.371  7.109   28.834 1.00 7.03  ? 196  THR A C   1 
ATOM   1495 O  O   . THR A 1 219 ? 10.087  5.934   28.615 1.00 7.09  ? 196  THR A O   1 
ATOM   1496 C  CB  . THR A 1 219 ? 11.384  7.515   26.577 1.00 8.78  ? 196  THR A CB  1 
ATOM   1497 O  OG1 . THR A 1 219 ? 12.726  7.510   27.108 1.00 10.18 ? 196  THR A OG1 1 
ATOM   1498 C  CG2 . THR A 1 219 ? 11.309  8.343   25.325 1.00 9.85  ? 196  THR A CG2 1 
ATOM   1499 N  N   A VAL A 1 220 ? 10.444  7.597   30.065 0.70 6.93  ? 197  VAL A N   1 
ATOM   1500 N  N   B VAL A 1 220 ? 10.471  7.643   30.053 0.30 6.32  ? 197  VAL A N   1 
ATOM   1501 C  CA  A VAL A 1 220 ? 10.376  6.672   31.183 0.70 7.12  ? 197  VAL A CA  1 
ATOM   1502 C  CA  B VAL A 1 220 ? 10.315  6.869   31.272 0.30 5.92  ? 197  VAL A CA  1 
ATOM   1503 C  C   A VAL A 1 220 ? 8.987   6.026   31.285 0.70 6.53  ? 197  VAL A C   1 
ATOM   1504 C  C   B VAL A 1 220 ? 9.030   6.051   31.228 0.30 5.98  ? 197  VAL A C   1 
ATOM   1505 O  O   A VAL A 1 220 ? 8.840   4.952   31.856 0.70 6.50  ? 197  VAL A O   1 
ATOM   1506 O  O   B VAL A 1 220 ? 9.018   4.896   31.616 0.30 5.67  ? 197  VAL A O   1 
ATOM   1507 C  CB  A VAL A 1 220 ? 10.763  7.296   32.531 0.70 8.85  ? 197  VAL A CB  1 
ATOM   1508 C  CB  B VAL A 1 220 ? 10.317  7.807   32.491 0.30 5.70  ? 197  VAL A CB  1 
ATOM   1509 C  CG1 A VAL A 1 220 ? 12.144  7.922   32.518 0.70 8.32  ? 197  VAL A CG1 1 
ATOM   1510 C  CG1 B VAL A 1 220 ? 9.586   7.211   33.689 0.30 5.69  ? 197  VAL A CG1 1 
ATOM   1511 C  CG2 A VAL A 1 220 ? 9.749   8.297   33.025 0.70 10.28 ? 197  VAL A CG2 1 
ATOM   1512 C  CG2 B VAL A 1 220 ? 11.737  8.165   32.896 0.30 5.61  ? 197  VAL A CG2 1 
ATOM   1513 N  N   . VAL A 1 221 ? 7.984   6.672   30.692 1.00 6.55  ? 198  VAL A N   1 
ATOM   1514 C  CA  . VAL A 1 221 ? 6.629   6.155   30.684 1.00 6.25  ? 198  VAL A CA  1 
ATOM   1515 C  C   . VAL A 1 221 ? 6.445   4.948   29.765 1.00 5.90  ? 198  VAL A C   1 
ATOM   1516 O  O   . VAL A 1 221 ? 5.391   4.327   29.805 1.00 6.65  ? 198  VAL A O   1 
ATOM   1517 C  CB  . VAL A 1 221 ? 5.641   7.250   30.270 1.00 7.29  ? 198  VAL A CB  1 
ATOM   1518 C  CG1 . VAL A 1 221 ? 5.583   8.365   31.309 1.00 7.60  ? 198  VAL A CG1 1 
ATOM   1519 C  CG2 . VAL A 1 221 ? 5.912   7.823   28.890 1.00 7.78  ? 198  VAL A CG2 1 
ATOM   1520 N  N   . GLN A 1 222 ? 7.462   4.542   29.005 1.00 5.54  ? 199  GLN A N   1 
ATOM   1521 C  CA  . GLN A 1 222 ? 7.410   3.278   28.273 1.00 5.90  ? 199  GLN A CA  1 
ATOM   1522 C  C   . GLN A 1 222 ? 7.454   2.074   29.199 1.00 6.29  ? 199  GLN A C   1 
ATOM   1523 O  O   . GLN A 1 222 ? 7.038   0.988   28.807 1.00 6.23  ? 199  GLN A O   1 
ATOM   1524 C  CB  . GLN A 1 222 ? 8.555   3.200   27.260 1.00 5.59  ? 199  GLN A CB  1 
ATOM   1525 C  CG  . GLN A 1 222 ? 8.390   4.223   26.156 1.00 5.77  ? 199  GLN A CG  1 
ATOM   1526 C  CD  . GLN A 1 222 ? 9.467   4.259   25.114 1.00 6.31  ? 199  GLN A CD  1 
ATOM   1527 O  OE1 . GLN A 1 222 ? 10.325  3.367   25.015 1.00 6.60  ? 199  GLN A OE1 1 
ATOM   1528 N  NE2 . GLN A 1 222 ? 9.406   5.267   24.260 1.00 6.86  ? 199  GLN A NE2 1 
ATOM   1529 N  N   . GLN A 1 223 ? 7.997   2.234   30.415 1.00 6.33  ? 200  GLN A N   1 
ATOM   1530 C  CA  . GLN A 1 223 ? 8.193   1.099   31.309 1.00 6.53  ? 200  GLN A CA  1 
ATOM   1531 C  C   . GLN A 1 223 ? 6.850   0.525   31.749 1.00 6.35  ? 200  GLN A C   1 
ATOM   1532 O  O   . GLN A 1 223 ? 5.879   1.256   32.023 1.00 6.56  ? 200  GLN A O   1 
ATOM   1533 C  CB  . GLN A 1 223 ? 9.046   1.540   32.499 1.00 7.14  ? 200  GLN A CB  1 
ATOM   1534 C  CG  . GLN A 1 223 ? 10.463  1.851   32.082 1.00 7.75  ? 200  GLN A CG  1 
ATOM   1535 C  CD  . GLN A 1 223 ? 11.231  2.425   33.227 1.00 9.04  ? 200  GLN A CD  1 
ATOM   1536 O  OE1 . GLN A 1 223 ? 12.014  1.730   33.899 1.00 11.14 ? 200  GLN A OE1 1 
ATOM   1537 N  NE2 . GLN A 1 223 ? 10.984  3.682   33.525 1.00 9.21  ? 200  GLN A NE2 1 
ATOM   1538 N  N   . LYS A 1 224 ? 6.866   -0.799  31.946 1.00 6.50  ? 201  LYS A N   1 
ATOM   1539 C  CA  . LYS A 1 224 ? 5.698   -1.528  32.406 1.00 6.74  ? 201  LYS A CA  1 
ATOM   1540 C  C   . LYS A 1 224 ? 5.118   -0.946  33.691 1.00 6.93  ? 201  LYS A C   1 
ATOM   1541 O  O   . LYS A 1 224 ? 3.892   -0.922  33.858 1.00 7.13  ? 201  LYS A O   1 
ATOM   1542 C  CB  . LYS A 1 224 ? 6.083   -3.012  32.565 1.00 7.43  ? 201  LYS A CB  1 
ATOM   1543 C  CG  . LYS A 1 224 ? 4.946   -3.920  33.011 1.00 9.44  ? 201  LYS A CG  1 
ATOM   1544 C  CD  . LYS A 1 224 ? 3.798   -4.034  32.031 1.00 10.82 ? 201  LYS A CD  1 
ATOM   1545 C  CE  . LYS A 1 224 ? 2.919   -5.182  32.445 1.00 12.03 ? 201  LYS A CE  1 
ATOM   1546 N  NZ  . LYS A 1 224 ? 1.741   -5.319  31.573 1.00 14.54 ? 201  LYS A NZ  1 
ATOM   1547 N  N   . SER A 1 225 ? 5.960   -0.483  34.592 1.00 7.33  ? 202  SER A N   1 
ATOM   1548 C  CA  . SER A 1 225 ? 5.503   0.067   35.866 1.00 7.60  ? 202  SER A CA  1 
ATOM   1549 C  C   . SER A 1 225 ? 4.638   1.311   35.722 1.00 7.58  ? 202  SER A C   1 
ATOM   1550 O  O   . SER A 1 225 ? 3.943   1.703   36.688 1.00 7.73  ? 202  SER A O   1 
ATOM   1551 C  CB  . SER A 1 225 ? 6.719   0.363   36.721 1.00 8.04  ? 202  SER A CB  1 
ATOM   1552 O  OG  . SER A 1 225 ? 7.563   1.256   36.059 1.00 8.76  ? 202  SER A OG  1 
ATOM   1553 N  N   . TYR A 1 226 ? 4.634   1.959   34.530 1.00 6.69  ? 203  TYR A N   1 
ATOM   1554 C  CA  . TYR A 1 226 ? 3.804   3.122   34.248 1.00 5.93  ? 203  TYR A CA  1 
ATOM   1555 C  C   . TYR A 1 226 ? 2.625   2.779   33.347 1.00 5.89  ? 203  TYR A C   1 
ATOM   1556 O  O   . TYR A 1 226 ? 1.833   3.676   33.019 1.00 6.12  ? 203  TYR A O   1 
ATOM   1557 C  CB  . TYR A 1 226 ? 4.631   4.220   33.602 1.00 6.82  ? 203  TYR A CB  1 
ATOM   1558 C  CG  . TYR A 1 226 ? 5.593   4.915   34.547 1.00 7.37  ? 203  TYR A CG  1 
ATOM   1559 C  CD1 . TYR A 1 226 ? 6.864   4.397   34.772 1.00 8.56  ? 203  TYR A CD1 1 
ATOM   1560 C  CD2 . TYR A 1 226 ? 5.232   6.105   35.183 1.00 7.38  ? 203  TYR A CD2 1 
ATOM   1561 C  CE1 . TYR A 1 226 ? 7.762   5.067   35.600 1.00 9.07  ? 203  TYR A CE1 1 
ATOM   1562 C  CE2 . TYR A 1 226 ? 6.098   6.741   36.062 1.00 8.54  ? 203  TYR A CE2 1 
ATOM   1563 C  CZ  . TYR A 1 226 ? 7.359   6.223   36.238 1.00 9.15  ? 203  TYR A CZ  1 
ATOM   1564 O  OH  . TYR A 1 226 ? 8.262   6.830   37.109 1.00 11.02 ? 203  TYR A OH  1 
ATOM   1565 N  N   . VAL A 1 227 ? 2.467   1.523   32.935 1.00 5.73  ? 204  VAL A N   1 
ATOM   1566 C  CA  . VAL A 1 227 ? 1.479   1.199   31.904 1.00 5.75  ? 204  VAL A CA  1 
ATOM   1567 C  C   . VAL A 1 227 ? 0.063   1.104   32.457 1.00 6.23  ? 204  VAL A C   1 
ATOM   1568 O  O   . VAL A 1 227 ? -0.228  0.473   33.482 1.00 6.86  ? 204  VAL A O   1 
ATOM   1569 C  CB  . VAL A 1 227 ? 1.880   -0.056  31.120 1.00 6.29  ? 204  VAL A CB  1 
ATOM   1570 C  CG1 . VAL A 1 227 ? 0.754   -0.569  30.214 1.00 6.86  ? 204  VAL A CG1 1 
ATOM   1571 C  CG2 . VAL A 1 227 ? 3.119   0.225   30.303 1.00 6.79  ? 204  VAL A CG2 1 
ATOM   1572 N  N   . GLU A 1 228 ? -0.871  1.706   31.729 1.00 5.31  ? 205  GLU A N   1 
ATOM   1573 C  CA  . GLU A 1 228 ? -2.315  1.526   31.939 1.00 5.52  ? 205  GLU A CA  1 
ATOM   1574 C  C   . GLU A 1 228 ? -3.016  1.815   30.604 1.00 5.71  ? 205  GLU A C   1 
ATOM   1575 O  O   . GLU A 1 228 ? -2.381  2.186   29.622 1.00 5.84  ? 205  GLU A O   1 
ATOM   1576 C  CB  . GLU A 1 228 ? -2.852  2.350   33.116 1.00 6.16  ? 205  GLU A CB  1 
ATOM   1577 C  CG  . GLU A 1 228 ? -3.375  1.569   34.327 1.00 6.50  ? 205  GLU A CG  1 
ATOM   1578 C  CD  . GLU A 1 228 ? -4.651  0.814   34.091 1.00 8.06  ? 205  GLU A CD  1 
ATOM   1579 O  OE1 . GLU A 1 228 ? -5.150  0.155   35.073 1.00 8.23  ? 205  GLU A OE1 1 
ATOM   1580 O  OE2 . GLU A 1 228 ? -5.237  0.804   32.986 1.00 8.06  ? 205  GLU A OE2 1 
ATOM   1581 N  N   . ARG A 1 229 ? -4.322  1.594   30.579 1.00 5.43  ? 206  ARG A N   1 
ATOM   1582 C  CA  . ARG A 1 229 ? -5.115  1.641   29.377 1.00 5.51  ? 206  ARG A CA  1 
ATOM   1583 C  C   . ARG A 1 229 ? -5.166  3.046   28.803 1.00 5.63  ? 206  ARG A C   1 
ATOM   1584 O  O   . ARG A 1 229 ? -5.559  3.992   29.500 1.00 6.02  ? 206  ARG A O   1 
ATOM   1585 C  CB  . ARG A 1 229 ? -6.531  1.175   29.730 1.00 5.58  ? 206  ARG A CB  1 
ATOM   1586 C  CG  . ARG A 1 229 ? -6.581  -0.312  30.080 1.00 6.10  ? 206  ARG A CG  1 
ATOM   1587 C  CD  . ARG A 1 229 ? -7.818  -0.736  30.845 1.00 6.49  ? 206  ARG A CD  1 
ATOM   1588 N  NE  . ARG A 1 229 ? -7.649  -0.346  32.250 1.00 7.10  ? 206  ARG A NE  1 
ATOM   1589 C  CZ  . ARG A 1 229 ? -8.542  -0.502  33.215 1.00 7.13  ? 206  ARG A CZ  1 
ATOM   1590 N  NH1 . ARG A 1 229 ? -9.721  -0.992  32.951 1.00 7.35  ? 206  ARG A NH1 1 
ATOM   1591 N  NH2 . ARG A 1 229 ? -8.164  -0.243  34.462 1.00 8.06  ? 206  ARG A NH2 1 
ATOM   1592 N  N   . ALA A 1 230 ? -4.846  3.169   27.507 1.00 5.01  ? 207  ALA A N   1 
ATOM   1593 C  CA  . ALA A 1 230 ? -4.791  4.486   26.854 1.00 5.32  ? 207  ALA A CA  1 
ATOM   1594 C  C   . ALA A 1 230 ? -4.884  4.231   25.351 1.00 5.11  ? 207  ALA A C   1 
ATOM   1595 O  O   . ALA A 1 230 ? -3.919  3.864   24.694 1.00 6.02  ? 207  ALA A O   1 
ATOM   1596 C  CB  . ALA A 1 230 ? -3.571  5.236   27.233 1.00 5.49  ? 207  ALA A CB  1 
ATOM   1597 N  N   A SER A 1 231 ? -6.083  4.409   24.783 0.50 5.39  ? 208  SER A N   1 
ATOM   1598 N  N   B SER A 1 231 ? -6.073  4.402   24.793 0.50 4.81  ? 208  SER A N   1 
ATOM   1599 C  CA  A SER A 1 231 ? -6.322  4.114   23.366 0.50 5.75  ? 208  SER A CA  1 
ATOM   1600 C  CA  B SER A 1 231 ? -6.303  4.070   23.391 0.50 4.73  ? 208  SER A CA  1 
ATOM   1601 C  C   A SER A 1 231 ? -5.829  5.230   22.457 0.50 5.33  ? 208  SER A C   1 
ATOM   1602 C  C   B SER A 1 231 ? -5.835  5.202   22.479 0.50 4.77  ? 208  SER A C   1 
ATOM   1603 O  O   A SER A 1 231 ? -6.007  6.430   22.731 0.50 5.28  ? 208  SER A O   1 
ATOM   1604 O  O   B SER A 1 231 ? -5.958  6.397   22.823 0.50 4.87  ? 208  SER A O   1 
ATOM   1605 C  CB  A SER A 1 231 ? -7.790  3.888   23.064 0.50 6.30  ? 208  SER A CB  1 
ATOM   1606 C  CB  B SER A 1 231 ? -7.765  3.778   23.191 0.50 4.54  ? 208  SER A CB  1 
ATOM   1607 O  OG  A SER A 1 231 ? -8.275  2.720   23.708 0.50 7.51  ? 208  SER A OG  1 
ATOM   1608 O  OG  B SER A 1 231 ? -8.078  3.549   21.831 0.50 4.21  ? 208  SER A OG  1 
ATOM   1609 N  N   . ALA A 1 232 ? -5.270  4.850   21.306 1.00 4.79  ? 209  ALA A N   1 
ATOM   1610 C  CA  . ALA A 1 232 ? -4.973  5.789   20.222 1.00 5.06  ? 209  ALA A CA  1 
ATOM   1611 C  C   . ALA A 1 232 ? -6.214  6.075   19.392 1.00 5.44  ? 209  ALA A C   1 
ATOM   1612 O  O   . ALA A 1 232 ? -6.363  7.148   18.801 1.00 5.68  ? 209  ALA A O   1 
ATOM   1613 C  CB  . ALA A 1 232 ? -3.872  5.262   19.361 1.00 5.76  ? 209  ALA A CB  1 
ATOM   1614 N  N   . LEU A 1 233 ? -7.057  5.057   19.219 1.00 5.68  ? 210  LEU A N   1 
ATOM   1615 C  CA  . LEU A 1 233 ? -8.115  5.052   18.224 1.00 5.01  ? 210  LEU A CA  1 
ATOM   1616 C  C   . LEU A 1 233 ? -9.202  4.129   18.737 1.00 5.06  ? 210  LEU A C   1 
ATOM   1617 O  O   . LEU A 1 233 ? -8.949  2.973   19.066 1.00 5.73  ? 210  LEU A O   1 
ATOM   1618 C  CB  . LEU A 1 233 ? -7.548  4.536   16.893 1.00 5.54  ? 210  LEU A CB  1 
ATOM   1619 C  CG  . LEU A 1 233 ? -8.516  4.391   15.728 1.00 5.76  ? 210  LEU A CG  1 
ATOM   1620 C  CD1 . LEU A 1 233 ? -9.148  5.705   15.345 1.00 6.11  ? 210  LEU A CD1 1 
ATOM   1621 C  CD2 . LEU A 1 233 ? -7.786  3.823   14.533 1.00 6.73  ? 210  LEU A CD2 1 
ATOM   1622 N  N   . ALA A 1 234 ? -10.421 4.637   18.778 1.00 5.34  ? 211  ALA A N   1 
ATOM   1623 C  CA  . ALA A 1 234 ? -11.582 3.899   19.225 1.00 5.48  ? 211  ALA A CA  1 
ATOM   1624 C  C   . ALA A 1 234 ? -12.713 4.091   18.245 1.00 5.67  ? 211  ALA A C   1 
ATOM   1625 O  O   . ALA A 1 234 ? -13.027 5.235   17.943 1.00 6.78  ? 211  ALA A O   1 
ATOM   1626 C  CB  . ALA A 1 234 ? -11.982 4.277   20.639 1.00 6.16  ? 211  ALA A CB  1 
ATOM   1627 N  N   . LEU A 1 235 ? -13.303 3.009   17.796 1.00 5.61  ? 212  LEU A N   1 
ATOM   1628 C  CA  . LEU A 1 235 ? -14.495 3.054   16.944 1.00 5.63  ? 212  LEU A CA  1 
ATOM   1629 C  C   . LEU A 1 235 ? -15.695 2.738   17.800 1.00 6.00  ? 212  LEU A C   1 
ATOM   1630 O  O   . LEU A 1 235 ? -15.689 1.776   18.569 1.00 6.13  ? 212  LEU A O   1 
ATOM   1631 C  CB  . LEU A 1 235 ? -14.380 2.051   15.805 1.00 5.89  ? 212  LEU A CB  1 
ATOM   1632 C  CG  . LEU A 1 235 ? -13.027 1.970   15.104 1.00 6.52  ? 212  LEU A CG  1 
ATOM   1633 C  CD1 . LEU A 1 235 ? -13.141 0.914   14.019 1.00 6.77  ? 212  LEU A CD1 1 
ATOM   1634 C  CD2 . LEU A 1 235 ? -12.537 3.309   14.535 1.00 6.87  ? 212  LEU A CD2 1 
ATOM   1635 N  N   . GLY A 1 236 ? -16.760 3.507   17.637 1.00 6.26  ? 213  GLY A N   1 
ATOM   1636 C  CA  . GLY A 1 236 ? -18.026 3.259   18.318 1.00 6.32  ? 213  GLY A CA  1 
ATOM   1637 C  C   . GLY A 1 236 ? -18.714 2.018   17.774 1.00 7.02  ? 213  GLY A C   1 
ATOM   1638 O  O   . GLY A 1 236 ? -18.219 1.286   16.934 1.00 7.98  ? 213  GLY A O   1 
ATOM   1639 N  N   . ASN A 1 237 ? -19.900 1.788   18.310 1.00 7.66  ? 214  ASN A N   1 
ATOM   1640 C  CA  . ASN A 1 237 ? -20.713 0.606   17.934 1.00 7.35  ? 214  ASN A CA  1 
ATOM   1641 C  C   . ASN A 1 237 ? -21.682 0.914   16.794 1.00 7.83  ? 214  ASN A C   1 
ATOM   1642 O  O   . ASN A 1 237 ? -22.031 2.082   16.592 1.00 8.30  ? 214  ASN A O   1 
ATOM   1643 C  CB  . ASN A 1 237 ? -21.494 0.063   19.138 1.00 8.26  ? 214  ASN A CB  1 
ATOM   1644 C  CG  . ASN A 1 237 ? -22.312 1.140   19.808 1.00 9.50  ? 214  ASN A CG  1 
ATOM   1645 O  OD1 . ASN A 1 237 ? -21.781 1.926   20.594 1.00 11.40 ? 214  ASN A OD1 1 
ATOM   1646 N  ND2 . ASN A 1 237 ? -23.600 1.196   19.517 1.00 9.66  ? 214  ASN A ND2 1 
ATOM   1647 N  N   . ASN A 1 238 ? -22.081 -0.133  16.080 1.00 7.16  ? 215  ASN A N   1 
ATOM   1648 C  CA  . ASN A 1 238 ? -23.130 -0.039  15.018 1.00 7.20  ? 215  ASN A CA  1 
ATOM   1649 C  C   . ASN A 1 238 ? -22.727 0.868   13.850 1.00 8.05  ? 215  ASN A C   1 
ATOM   1650 O  O   . ASN A 1 238 ? -23.601 1.490   13.286 1.00 9.86  ? 215  ASN A O   1 
ATOM   1651 C  CB  . ASN A 1 238 ? -24.488 0.344   15.612 1.00 7.43  ? 215  ASN A CB  1 
ATOM   1652 C  CG  . ASN A 1 238 ? -24.989 -0.712  16.572 1.00 7.90  ? 215  ASN A CG  1 
ATOM   1653 O  OD1 . ASN A 1 238 ? -24.579 -0.747  17.733 1.00 11.22 ? 215  ASN A OD1 1 
ATOM   1654 N  ND2 . ASN A 1 238 ? -25.850 -1.601  16.112 1.00 7.22  ? 215  ASN A ND2 1 
ATOM   1655 N  N   . LEU A 1 239 ? -21.439 0.915   13.541 1.00 7.07  ? 216  LEU A N   1 
ATOM   1656 C  CA  . LEU A 1 239 ? -20.965 1.759   12.442 1.00 7.01  ? 216  LEU A CA  1 
ATOM   1657 C  C   . LEU A 1 239 ? -20.632 0.905   11.232 1.00 6.05  ? 216  LEU A C   1 
ATOM   1658 O  O   . LEU A 1 239 ? -20.321 -0.281  11.339 1.00 6.98  ? 216  LEU A O   1 
ATOM   1659 C  CB  . LEU A 1 239 ? -19.727 2.523   12.875 1.00 6.47  ? 216  LEU A CB  1 
ATOM   1660 C  CG  . LEU A 1 239 ? -19.842 3.353   14.150 1.00 7.22  ? 216  LEU A CG  1 
ATOM   1661 C  CD1 . LEU A 1 239 ? -18.485 3.972   14.496 1.00 7.66  ? 216  LEU A CD1 1 
ATOM   1662 C  CD2 . LEU A 1 239 ? -20.947 4.398   14.062 1.00 7.89  ? 216  LEU A CD2 1 
ATOM   1663 N  N   . SER A 1 240 ? -20.659 1.530   10.046 1.00 6.37  ? 217  SER A N   1 
ATOM   1664 C  CA  . SER A 1 240 ? -20.459 0.827   8.804  1.00 6.75  ? 217  SER A CA  1 
ATOM   1665 C  C   . SER A 1 240 ? -19.450 1.532   7.919  1.00 6.71  ? 217  SER A C   1 
ATOM   1666 O  O   . SER A 1 240 ? -19.220 2.720   8.021  1.00 7.28  ? 217  SER A O   1 
ATOM   1667 C  CB  . SER A 1 240 ? -21.794 0.766   8.031  1.00 8.31  ? 217  SER A CB  1 
ATOM   1668 O  OG  . SER A 1 240 ? -22.783 0.127   8.829  1.00 10.08 ? 217  SER A OG  1 
ATOM   1669 N  N   . ASP A 1 241 ? -18.820 0.736   7.064  1.00 7.61  ? 218  ASP A N   1 
ATOM   1670 C  CA  . ASP A 1 241 ? -17.973 1.193   5.980  1.00 7.94  ? 218  ASP A CA  1 
ATOM   1671 C  C   . ASP A 1 241 ? -16.766 2.018   6.449  1.00 8.05  ? 218  ASP A C   1 
ATOM   1672 O  O   . ASP A 1 241 ? -16.403 3.006   5.823  1.00 8.37  ? 218  ASP A O   1 
ATOM   1673 C  CB  . ASP A 1 241 ? -18.834 1.920   4.942  1.00 10.00 ? 218  ASP A CB  1 
ATOM   1674 C  CG  . ASP A 1 241 ? -19.950 1.070   4.353  1.00 12.89 ? 218  ASP A CG  1 
ATOM   1675 O  OD1 . ASP A 1 241 ? -19.594 -0.021  3.872  1.00 19.74 ? 218  ASP A OD1 1 
ATOM   1676 O  OD2 . ASP A 1 241 ? -21.061 1.491   4.446  1.00 16.62 ? 218  ASP A OD2 1 
ATOM   1677 N  N   . ILE A 1 242 ? -16.124 1.596   7.530  1.00 6.87  ? 219  ILE A N   1 
ATOM   1678 C  CA  . ILE A 1 242 ? -14.908 2.233   8.018  1.00 7.21  ? 219  ILE A CA  1 
ATOM   1679 C  C   . ILE A 1 242 ? -13.704 1.554   7.393  1.00 6.84  ? 219  ILE A C   1 
ATOM   1680 O  O   . ILE A 1 242 ? -13.624 0.326   7.430  1.00 6.84  ? 219  ILE A O   1 
ATOM   1681 C  CB  . ILE A 1 242 ? -14.890 2.202   9.546  1.00 6.86  ? 219  ILE A CB  1 
ATOM   1682 C  CG1 . ILE A 1 242 ? -16.038 3.056   10.110 1.00 8.48  ? 219  ILE A CG1 1 
ATOM   1683 C  CG2 . ILE A 1 242 ? -13.531 2.653   10.041 1.00 7.18  ? 219  ILE A CG2 1 
ATOM   1684 C  CD1 . ILE A 1 242 ? -16.219 2.970   11.601 1.00 9.13  ? 219  ILE A CD1 1 
ATOM   1685 N  N   . VAL A 1 243 ? -12.787 2.320   6.823  1.00 7.16  ? 220  VAL A N   1 
ATOM   1686 C  CA  . VAL A 1 243 ? -11.612 1.759   6.179  1.00 6.77  ? 220  VAL A CA  1 
ATOM   1687 C  C   . VAL A 1 243 ? -10.390 2.619   6.449  1.00 7.34  ? 220  VAL A C   1 
ATOM   1688 O  O   . VAL A 1 243 ? -10.361 3.810   6.131  1.00 8.19  ? 220  VAL A O   1 
ATOM   1689 C  CB  . VAL A 1 243 ? -11.806 1.629   4.658  1.00 8.22  ? 220  VAL A CB  1 
ATOM   1690 C  CG1 . VAL A 1 243 ? -10.562 0.980   4.027  1.00 8.44  ? 220  VAL A CG1 1 
ATOM   1691 C  CG2 . VAL A 1 243 ? -13.075 0.879   4.278  1.00 8.99  ? 220  VAL A CG2 1 
ATOM   1692 N  N   . PHE A 1 244 ? -9.341  1.988   6.983  1.00 6.36  ? 221  PHE A N   1 
ATOM   1693 C  CA  . PHE A 1 244 ? -8.019  2.581   7.181  1.00 7.06  ? 221  PHE A CA  1 
ATOM   1694 C  C   . PHE A 1 244 ? -7.053  1.978   6.189  1.00 7.18  ? 221  PHE A C   1 
ATOM   1695 O  O   . PHE A 1 244 ? -7.015  0.752   6.074  1.00 7.62  ? 221  PHE A O   1 
ATOM   1696 C  CB  . PHE A 1 244 ? -7.518  2.302   8.605  1.00 6.60  ? 221  PHE A CB  1 
ATOM   1697 C  CG  . PHE A 1 244 ? -8.356  2.952   9.691  1.00 6.66  ? 221  PHE A CG  1 
ATOM   1698 C  CD1 . PHE A 1 244 ? -9.518  2.359   10.160 1.00 6.59  ? 221  PHE A CD1 1 
ATOM   1699 C  CD2 . PHE A 1 244 ? -7.984  4.177   10.203 1.00 6.70  ? 221  PHE A CD2 1 
ATOM   1700 C  CE1 . PHE A 1 244 ? -10.272 2.979   11.138 1.00 6.90  ? 221  PHE A CE1 1 
ATOM   1701 C  CE2 . PHE A 1 244 ? -8.760  4.784   11.160 1.00 6.88  ? 221  PHE A CE2 1 
ATOM   1702 C  CZ  . PHE A 1 244 ? -9.913  4.198   11.602 1.00 6.74  ? 221  PHE A CZ  1 
ATOM   1703 N  N   . THR A 1 245 ? -6.238  2.795   5.547  1.00 6.98  ? 222  THR A N   1 
ATOM   1704 C  CA  . THR A 1 245 ? -5.294  2.329   4.547  1.00 7.54  ? 222  THR A CA  1 
ATOM   1705 C  C   . THR A 1 245 ? -3.927  2.916   4.877  1.00 6.82  ? 222  THR A C   1 
ATOM   1706 O  O   . THR A 1 245 ? -3.783  4.126   4.963  1.00 6.89  ? 222  THR A O   1 
ATOM   1707 C  CB  . THR A 1 245 ? -5.723  2.771   3.160  1.00 8.60  ? 222  THR A CB  1 
ATOM   1708 O  OG1 . THR A 1 245 ? -7.042  2.280   2.914  1.00 10.64 ? 222  THR A OG1 1 
ATOM   1709 C  CG2 . THR A 1 245 ? -4.817  2.196   2.094  1.00 10.41 ? 222  THR A CG2 1 
ATOM   1710 N  N   A ASN A 1 246 ? -2.928  2.047   5.017  0.30 7.08  ? 223  ASN A N   1 
ATOM   1711 N  N   B ASN A 1 246 ? -2.902  2.078   5.000  0.70 7.21  ? 223  ASN A N   1 
ATOM   1712 C  CA  A ASN A 1 246 ? -1.554  2.469   5.223  0.30 7.22  ? 223  ASN A CA  1 
ATOM   1713 C  CA  B ASN A 1 246 ? -1.555  2.565   5.249  0.70 7.50  ? 223  ASN A CA  1 
ATOM   1714 C  C   A ASN A 1 246 ? -1.405  3.403   6.427  0.30 6.96  ? 223  ASN A C   1 
ATOM   1715 C  C   B ASN A 1 246 ? -1.496  3.544   6.417  0.70 6.94  ? 223  ASN A C   1 
ATOM   1716 O  O   A ASN A 1 246 ? -0.567  4.294   6.413  0.30 7.08  ? 223  ASN A O   1 
ATOM   1717 O  O   B ASN A 1 246 ? -0.909  4.624   6.364  0.70 7.15  ? 223  ASN A O   1 
ATOM   1718 C  CB  A ASN A 1 246 ? -0.943  3.134   3.983  0.30 7.88  ? 223  ASN A CB  1 
ATOM   1719 C  CB  B ASN A 1 246 ? -0.913  3.187   3.997  0.70 9.16  ? 223  ASN A CB  1 
ATOM   1720 C  CG  A ASN A 1 246 ? -1.173  2.368   2.697  0.30 8.96  ? 223  ASN A CG  1 
ATOM   1721 C  CG  B ASN A 1 246 ? 0.535   3.608   4.176  0.70 12.28 ? 223  ASN A CG  1 
ATOM   1722 O  OD1 A ASN A 1 246 ? -1.302  1.149   2.705  0.30 9.39  ? 223  ASN A OD1 1 
ATOM   1723 O  OD1 B ASN A 1 246 ? 1.307   2.893   4.824  0.70 14.26 ? 223  ASN A OD1 1 
ATOM   1724 N  ND2 A ASN A 1 246 ? -1.291  3.064   1.579  0.30 10.38 ? 223  ASN A ND2 1 
ATOM   1725 N  ND2 B ASN A 1 246 ? 0.899   4.778   3.667  0.70 16.27 ? 223  ASN A ND2 1 
ATOM   1726 N  N   . CYS A 1 247 ? -2.184  3.157   7.490  1.00 7.08  ? 224  CYS A N   1 
ATOM   1727 C  CA  . CYS A 1 247 ? -2.120  3.915   8.726  1.00 6.38  ? 224  CYS A CA  1 
ATOM   1728 C  C   . CYS A 1 247 ? -1.353  3.132   9.785  1.00 6.08  ? 224  CYS A C   1 
ATOM   1729 O  O   . CYS A 1 247 ? -1.168  1.917   9.688  1.00 6.97  ? 224  CYS A O   1 
ATOM   1730 C  CB  . CYS A 1 247 ? -3.497  4.244   9.268  1.00 6.66  ? 224  CYS A CB  1 
ATOM   1731 S  SG  . CYS A 1 247 ? -4.467  5.372   8.226  1.00 7.34  ? 224  CYS A SG  1 
ATOM   1732 N  N   . LYS A 1 248 ? -0.934  3.851   10.826 1.00 5.64  ? 225  LYS A N   1 
ATOM   1733 C  CA  . LYS A 1 248 ? -0.288  3.233   11.983 1.00 5.35  ? 225  LYS A CA  1 
ATOM   1734 C  C   . LYS A 1 248 ? -1.087  3.614   13.210 1.00 5.71  ? 225  LYS A C   1 
ATOM   1735 O  O   . LYS A 1 248 ? -1.581  4.743   13.312 1.00 6.20  ? 225  LYS A O   1 
ATOM   1736 C  CB  . LYS A 1 248 ? 1.147   3.719   12.097 1.00 6.08  ? 225  LYS A CB  1 
ATOM   1737 C  CG  . LYS A 1 248 ? 1.905   3.137   13.269 1.00 5.85  ? 225  LYS A CG  1 
ATOM   1738 C  CD  . LYS A 1 248 ? 3.413   3.460   13.252 1.00 6.57  ? 225  LYS A CD  1 
ATOM   1739 C  CE  . LYS A 1 248 ? 4.100   2.720   12.116 1.00 7.27  ? 225  LYS A CE  1 
ATOM   1740 N  NZ  . LYS A 1 248 ? 5.545   2.946   12.097 1.00 7.25  ? 225  LYS A NZ  1 
ATOM   1741 N  N   . VAL A 1 249 ? -1.190  2.712   14.188 1.00 5.71  ? 226  VAL A N   1 
ATOM   1742 C  CA  . VAL A 1 249 ? -1.918  2.957   15.434 1.00 5.46  ? 226  VAL A CA  1 
ATOM   1743 C  C   . VAL A 1 249 ? -0.984  2.590   16.575 1.00 5.31  ? 226  VAL A C   1 
ATOM   1744 O  O   . VAL A 1 249 ? -0.577  1.433   16.685 1.00 5.58  ? 226  VAL A O   1 
ATOM   1745 C  CB  . VAL A 1 249 ? -3.234  2.185   15.462 1.00 5.63  ? 226  VAL A CB  1 
ATOM   1746 C  CG1 . VAL A 1 249 ? -4.107  2.631   16.635 1.00 6.26  ? 226  VAL A CG1 1 
ATOM   1747 C  CG2 . VAL A 1 249 ? -4.009  2.281   14.160 1.00 6.25  ? 226  VAL A CG2 1 
ATOM   1748 N  N   . VAL A 1 250 ? -0.619  3.585   17.381 1.00 5.32  ? 227  VAL A N   1 
ATOM   1749 C  CA  . VAL A 1 250 ? 0.465   3.484   18.359 1.00 5.56  ? 227  VAL A CA  1 
ATOM   1750 C  C   . VAL A 1 250 ? -0.069  3.577   19.786 1.00 5.16  ? 227  VAL A C   1 
ATOM   1751 O  O   . VAL A 1 250 ? -0.671  4.590   20.135 1.00 5.27  ? 227  VAL A O   1 
ATOM   1752 C  CB  . VAL A 1 250 ? 1.517   4.578   18.136 1.00 5.67  ? 227  VAL A CB  1 
ATOM   1753 C  CG1 . VAL A 1 250 ? 2.653   4.473   19.143 1.00 5.55  ? 227  VAL A CG1 1 
ATOM   1754 C  CG2 . VAL A 1 250 ? 2.099   4.510   16.731 1.00 6.11  ? 227  VAL A CG2 1 
ATOM   1755 N  N   . GLY A 1 251 ? 0.241   2.545   20.587 1.00 4.90  ? 228  GLY A N   1 
ATOM   1756 C  CA  . GLY A 1 251 ? -0.052  2.520   22.013 1.00 5.06  ? 228  GLY A CA  1 
ATOM   1757 C  C   . GLY A 1 251 ? 0.600   1.296   22.618 1.00 4.82  ? 228  GLY A C   1 
ATOM   1758 O  O   . GLY A 1 251 ? 1.359   0.585   21.944 1.00 5.15  ? 228  GLY A O   1 
ATOM   1759 N  N   . ARG A 1 252 ? 0.225   1.023   23.863 1.00 4.87  ? 229  ARG A N   1 
ATOM   1760 C  CA  . ARG A 1 252 ? 0.649   -0.181  24.561 1.00 5.19  ? 229  ARG A CA  1 
ATOM   1761 C  C   . ARG A 1 252 ? -0.575  -0.975  25.001 1.00 4.81  ? 229  ARG A C   1 
ATOM   1762 O  O   . ARG A 1 252 ? -0.953  -1.933  24.341 1.00 4.87  ? 229  ARG A O   1 
ATOM   1763 C  CB  . ARG A 1 252 ? 1.655   0.096   25.669 1.00 4.97  ? 229  ARG A CB  1 
ATOM   1764 C  CG  . ARG A 1 252 ? 2.901   0.768   25.086 1.00 5.53  ? 229  ARG A CG  1 
ATOM   1765 C  CD  . ARG A 1 252 ? 4.132   0.588   25.935 1.00 5.69  ? 229  ARG A CD  1 
ATOM   1766 N  NE  . ARG A 1 252 ? 5.286   1.265   25.344 1.00 5.67  ? 229  ARG A NE  1 
ATOM   1767 C  CZ  . ARG A 1 252 ? 6.459   0.740   25.086 1.00 5.66  ? 229  ARG A CZ  1 
ATOM   1768 N  NH1 . ARG A 1 252 ? 6.793   -0.413  25.609 1.00 6.03  ? 229  ARG A NH1 1 
ATOM   1769 N  NH2 . ARG A 1 252 ? 7.313   1.436   24.361 1.00 5.88  ? 229  ARG A NH2 1 
ATOM   1770 N  N   . GLN A 1 253 ? -1.167  -0.606  26.135 1.00 4.95  ? 230  GLN A N   1 
ATOM   1771 C  CA  . GLN A 1 253 ? -2.358  -1.340  26.622 1.00 4.96  ? 230  GLN A CA  1 
ATOM   1772 C  C   . GLN A 1 253 ? -3.637  -0.759  25.992 1.00 5.30  ? 230  GLN A C   1 
ATOM   1773 O  O   . GLN A 1 253 ? -3.891  0.428   26.143 1.00 5.43  ? 230  GLN A O   1 
ATOM   1774 C  CB  . GLN A 1 253 ? -2.380  -1.268  28.149 1.00 6.27  ? 230  GLN A CB  1 
ATOM   1775 C  CG  . GLN A 1 253 ? -3.481  -2.143  28.742 1.00 7.06  ? 230  GLN A CG  1 
ATOM   1776 C  CD  . GLN A 1 253 ? -3.413  -2.259  30.249 1.00 10.25 ? 230  GLN A CD  1 
ATOM   1777 O  OE1 . GLN A 1 253 ? -2.638  -1.578  30.920 1.00 13.18 ? 230  GLN A OE1 1 
ATOM   1778 N  NE2 . GLN A 1 253 ? -4.253  -3.110  30.806 1.00 10.19 ? 230  GLN A NE2 1 
ATOM   1779 N  N   . ASP A 1 254 ? -4.406  -1.626  25.332 1.00 4.96  ? 231  ASP A N   1 
ATOM   1780 C  CA  . ASP A 1 254 ? -5.689  -1.222  24.781 1.00 5.20  ? 231  ASP A CA  1 
ATOM   1781 C  C   . ASP A 1 254 ? -5.534  -0.137  23.714 1.00 4.63  ? 231  ASP A C   1 
ATOM   1782 O  O   . ASP A 1 254 ? -6.362  0.749   23.585 1.00 5.26  ? 231  ASP A O   1 
ATOM   1783 C  CB  . ASP A 1 254 ? -6.673  -0.794  25.846 1.00 5.82  ? 231  ASP A CB  1 
ATOM   1784 C  CG  . ASP A 1 254 ? -7.313  -1.907  26.626 1.00 6.26  ? 231  ASP A CG  1 
ATOM   1785 O  OD1 . ASP A 1 254 ? -7.035  -3.101  26.297 1.00 7.88  ? 231  ASP A OD1 1 
ATOM   1786 O  OD2 . ASP A 1 254 ? -8.108  -1.634  27.547 1.00 6.86  ? 231  ASP A OD2 1 
ATOM   1787 N  N   . THR A 1 255 ? -4.561  -0.322  22.806 1.00 4.85  ? 232  THR A N   1 
ATOM   1788 C  CA  . THR A 1 255 ? -4.290  0.669   21.754 1.00 4.59  ? 232  THR A CA  1 
ATOM   1789 C  C   . THR A 1 255 ? -5.529  0.972   20.924 1.00 4.76  ? 232  THR A C   1 
ATOM   1790 O  O   . THR A 1 255 ? -5.800  2.146   20.626 1.00 5.23  ? 232  THR A O   1 
ATOM   1791 C  CB  . THR A 1 255 ? -3.183  0.162   20.842 1.00 4.84  ? 232  THR A CB  1 
ATOM   1792 O  OG1 . THR A 1 255 ? -2.028  -0.086  21.656 1.00 5.30  ? 232  THR A OG1 1 
ATOM   1793 C  CG2 . THR A 1 255 ? -2.879  1.099   19.703 1.00 5.13  ? 232  THR A CG2 1 
ATOM   1794 N  N   . LEU A 1 256 ? -6.181  -0.075  20.389 1.00 4.61  ? 233  LEU A N   1 
ATOM   1795 C  CA  . LEU A 1 256 ? -7.193  0.071   19.335 1.00 4.92  ? 233  LEU A CA  1 
ATOM   1796 C  C   . LEU A 1 256 ? -8.466  -0.634  19.755 1.00 5.30  ? 233  LEU A C   1 
ATOM   1797 O  O   . LEU A 1 256 ? -8.455  -1.841  19.948 1.00 5.25  ? 233  LEU A O   1 
ATOM   1798 C  CB  . LEU A 1 256 ? -6.612  -0.526  18.049 1.00 5.48  ? 233  LEU A CB  1 
ATOM   1799 C  CG  . LEU A 1 256 ? -7.613  -0.641  16.883 1.00 7.02  ? 233  LEU A CG  1 
ATOM   1800 C  CD1 . LEU A 1 256 ? -8.241  0.692   16.507 1.00 8.92  ? 233  LEU A CD1 1 
ATOM   1801 C  CD2 . LEU A 1 256 ? -6.899  -1.244  15.680 1.00 8.43  ? 233  LEU A CD2 1 
ATOM   1802 N  N   . TYR A 1 257 ? -9.551  0.131   19.930 1.00 5.66  ? 234  TYR A N   1 
ATOM   1803 C  CA  . TYR A 1 257 ? -10.844 -0.405  20.293 1.00 5.32  ? 234  TYR A CA  1 
ATOM   1804 C  C   . TYR A 1 257 ? -11.774 -0.316  19.086 1.00 5.51  ? 234  TYR A C   1 
ATOM   1805 O  O   . TYR A 1 257 ? -11.825 0.693   18.379 1.00 5.16  ? 234  TYR A O   1 
ATOM   1806 C  CB  . TYR A 1 257 ? -11.459 0.424   21.422 1.00 5.37  ? 234  TYR A CB  1 
ATOM   1807 C  CG  . TYR A 1 257 ? -12.858 -0.000  21.805 1.00 5.41  ? 234  TYR A CG  1 
ATOM   1808 C  CD1 . TYR A 1 257 ? -13.049 -1.129  22.577 1.00 5.56  ? 234  TYR A CD1 1 
ATOM   1809 C  CD2 . TYR A 1 257 ? -13.979 0.679   21.356 1.00 6.47  ? 234  TYR A CD2 1 
ATOM   1810 C  CE1 . TYR A 1 257 ? -14.322 -1.537  22.959 1.00 5.74  ? 234  TYR A CE1 1 
ATOM   1811 C  CE2 . TYR A 1 257 ? -15.256 0.265   21.711 1.00 6.18  ? 234  TYR A CE2 1 
ATOM   1812 C  CZ  . TYR A 1 257 ? -15.421 -0.841  22.512 1.00 5.97  ? 234  TYR A CZ  1 
ATOM   1813 O  OH  . TYR A 1 257 ? -16.657 -1.260  22.918 1.00 7.28  ? 234  TYR A OH  1 
ATOM   1814 N  N   . GLY A 1 258 ? -12.666 -1.292  18.960 1.00 5.18  ? 235  GLY A N   1 
ATOM   1815 C  CA  . GLY A 1 258 ? -13.841 -1.132  18.115 1.00 5.74  ? 235  GLY A CA  1 
ATOM   1816 C  C   . GLY A 1 258 ? -15.064 -1.820  18.686 1.00 5.59  ? 235  GLY A C   1 
ATOM   1817 O  O   . GLY A 1 258 ? -14.994 -2.971  19.106 1.00 6.06  ? 235  GLY A O   1 
ATOM   1818 N  N   . GLY A 1 259 ? -16.186 -1.118  18.667 1.00 6.38  ? 236  GLY A N   1 
ATOM   1819 C  CA  . GLY A 1 259 ? -17.409 -1.581  19.284 1.00 6.15  ? 236  GLY A CA  1 
ATOM   1820 C  C   . GLY A 1 259 ? -18.148 -2.644  18.477 1.00 6.03  ? 236  GLY A C   1 
ATOM   1821 O  O   . GLY A 1 259 ? -17.913 -2.896  17.307 1.00 6.26  ? 236  GLY A O   1 
ATOM   1822 N  N   . LYS A 1 260 ? -19.129 -3.267  19.169 1.00 6.95  ? 237  LYS A N   1 
ATOM   1823 C  CA  . LYS A 1 260 ? -19.973 -4.266  18.560 1.00 6.71  ? 237  LYS A CA  1 
ATOM   1824 C  C   . LYS A 1 260 ? -20.718 -3.718  17.355 1.00 6.76  ? 237  LYS A C   1 
ATOM   1825 O  O   . LYS A 1 260 ? -21.124 -2.557  17.308 1.00 7.38  ? 237  LYS A O   1 
ATOM   1826 C  CB  . LYS A 1 260 ? -21.035 -4.776  19.531 1.00 7.11  ? 237  LYS A CB  1 
ATOM   1827 C  CG  . LYS A 1 260 ? -20.427 -5.527  20.692 1.00 8.23  ? 237  LYS A CG  1 
ATOM   1828 C  CD  . LYS A 1 260 ? -21.521 -6.009  21.651 1.00 8.83  ? 237  LYS A CD  1 
ATOM   1829 C  CE  . LYS A 1 260 ? -21.048 -7.046  22.611 1.00 9.32  ? 237  LYS A CE  1 
ATOM   1830 N  NZ  . LYS A 1 260 ? -19.994 -6.556  23.469 1.00 10.87 ? 237  LYS A NZ  1 
ATOM   1831 N  N   . MET A 1 261 ? -20.883 -4.608  16.388 1.00 6.35  ? 238  MET A N   1 
ATOM   1832 C  CA  . MET A 1 261 ? -21.716 -4.335  15.183 1.00 6.54  ? 238  MET A CA  1 
ATOM   1833 C  C   . MET A 1 261 ? -21.137 -3.238  14.305 1.00 7.06  ? 238  MET A C   1 
ATOM   1834 O  O   . MET A 1 261 ? -21.864 -2.685  13.497 1.00 7.71  ? 238  MET A O   1 
ATOM   1835 C  CB  . MET A 1 261 ? -23.161 -4.049  15.569 1.00 6.40  ? 238  MET A CB  1 
ATOM   1836 C  CG  . MET A 1 261 ? -23.716 -5.156  16.447 1.00 6.01  ? 238  MET A CG  1 
ATOM   1837 S  SD  . MET A 1 261 ? -25.506 -5.137  16.672 1.00 6.60  ? 238  MET A SD  1 
ATOM   1838 C  CE  . MET A 1 261 ? -26.070 -5.418  14.989 1.00 8.99  ? 238  MET A CE  1 
ATOM   1839 N  N   . THR A 1 262 ? -19.852 -3.010  14.450 1.00 7.02  ? 239  THR A N   1 
ATOM   1840 C  CA  . THR A 1 262 ? -19.129 -2.082  13.602 1.00 6.87  ? 239  THR A CA  1 
ATOM   1841 C  C   . THR A 1 262 ? -18.306 -2.900  12.621 1.00 7.34  ? 239  THR A C   1 
ATOM   1842 O  O   . THR A 1 262 ? -17.608 -3.851  13.021 1.00 8.59  ? 239  THR A O   1 
ATOM   1843 C  CB  . THR A 1 262 ? -18.241 -1.166  14.440 1.00 6.65  ? 239  THR A CB  1 
ATOM   1844 O  OG1 . THR A 1 262 ? -19.165 -0.226  14.996 1.00 6.46  ? 239  THR A OG1 1 
ATOM   1845 C  CG2 . THR A 1 262 ? -17.152 -0.456  13.647 1.00 6.75  ? 239  THR A CG2 1 
ATOM   1846 N  N   . TYR A 1 263 ? -18.335 -2.506  11.351 1.00 6.92  ? 240  TYR A N   1 
ATOM   1847 C  CA  . TYR A 1 263 ? -17.509 -3.087  10.307 1.00 6.79  ? 240  TYR A CA  1 
ATOM   1848 C  C   . TYR A 1 263 ? -16.370 -2.146  9.967  1.00 6.98  ? 240  TYR A C   1 
ATOM   1849 O  O   . TYR A 1 263 ? -16.639 -1.007  9.568  1.00 7.82  ? 240  TYR A O   1 
ATOM   1850 C  CB  . TYR A 1 263 ? -18.357 -3.308  9.054  1.00 7.12  ? 240  TYR A CB  1 
ATOM   1851 C  CG  . TYR A 1 263 ? -19.386 -4.387  9.269  1.00 8.71  ? 240  TYR A CG  1 
ATOM   1852 C  CD1 . TYR A 1 263 ? -20.638 -4.068  9.791  1.00 10.26 ? 240  TYR A CD1 1 
ATOM   1853 C  CD2 . TYR A 1 263 ? -19.112 -5.726  9.051  1.00 8.59  ? 240  TYR A CD2 1 
ATOM   1854 C  CE1 . TYR A 1 263 ? -21.577 -5.036  10.115 1.00 11.48 ? 240  TYR A CE1 1 
ATOM   1855 C  CE2 . TYR A 1 263 ? -20.064 -6.696  9.298  1.00 10.73 ? 240  TYR A CE2 1 
ATOM   1856 C  CZ  . TYR A 1 263 ? -21.273 -6.348  9.835  1.00 11.99 ? 240  TYR A CZ  1 
ATOM   1857 O  OH  . TYR A 1 263 ? -22.249 -7.302  10.157 1.00 16.53 ? 240  TYR A OH  1 
ATOM   1858 N  N   . ALA A 1 264 ? -15.128 -2.594  10.183 1.00 6.13  ? 241  ALA A N   1 
ATOM   1859 C  CA  . ALA A 1 264 ? -13.943 -1.783  9.948  1.00 6.88  ? 241  ALA A CA  1 
ATOM   1860 C  C   . ALA A 1 264 ? -12.866 -2.642  9.306  1.00 6.39  ? 241  ALA A C   1 
ATOM   1861 O  O   . ALA A 1 264 ? -12.673 -3.783  9.725  1.00 6.92  ? 241  ALA A O   1 
ATOM   1862 C  CB  . ALA A 1 264 ? -13.424 -1.168  11.247 1.00 7.24  ? 241  ALA A CB  1 
ATOM   1863 N  N   . GLU A 1 265 ? -12.151 -2.060  8.344  1.00 6.67  ? 242  GLU A N   1 
ATOM   1864 C  CA  . GLU A 1 265 ? -11.059 -2.738  7.700  1.00 6.39  ? 242  GLU A CA  1 
ATOM   1865 C  C   . GLU A 1 265 ? -9.813  -1.883  7.841  1.00 6.66  ? 242  GLU A C   1 
ATOM   1866 O  O   . GLU A 1 265 ? -9.882  -0.654  7.766  1.00 6.95  ? 242  GLU A O   1 
ATOM   1867 C  CB  . GLU A 1 265 ? -11.342 -2.966  6.215  1.00 7.13  ? 242  GLU A CB  1 
ATOM   1868 C  CG  . GLU A 1 265 ? -12.684 -3.654  5.988  1.00 7.55  ? 242  GLU A CG  1 
ATOM   1869 C  CD  . GLU A 1 265 ? -12.984 -4.125  4.577  1.00 8.16  ? 242  GLU A CD  1 
ATOM   1870 O  OE1 . GLU A 1 265 ? -12.065 -4.257  3.745  1.00 9.10  ? 242  GLU A OE1 1 
ATOM   1871 O  OE2 . GLU A 1 265 ? -14.195 -4.408  4.321  1.00 8.14  ? 242  GLU A OE2 1 
ATOM   1872 N  N   . PHE A 1 266 ? -8.691  -2.556  8.064  1.00 6.02  ? 243  PHE A N   1 
ATOM   1873 C  CA  . PHE A 1 266 ? -7.377  -1.981  8.237  1.00 6.43  ? 243  PHE A CA  1 
ATOM   1874 C  C   . PHE A 1 266 ? -6.493  -2.637  7.204  1.00 6.53  ? 243  PHE A C   1 
ATOM   1875 O  O   . PHE A 1 266 ? -6.140  -3.811  7.374  1.00 7.28  ? 243  PHE A O   1 
ATOM   1876 C  CB  . PHE A 1 266 ? -6.856  -2.249  9.645  1.00 6.51  ? 243  PHE A CB  1 
ATOM   1877 C  CG  . PHE A 1 266 ? -7.702  -1.636  10.732 1.00 6.89  ? 243  PHE A CG  1 
ATOM   1878 C  CD1 . PHE A 1 266 ? -8.856  -2.269  11.170 1.00 8.14  ? 243  PHE A CD1 1 
ATOM   1879 C  CD2 . PHE A 1 266 ? -7.367  -0.411  11.310 1.00 8.13  ? 243  PHE A CD2 1 
ATOM   1880 C  CE1 . PHE A 1 266 ? -9.667  -1.681  12.145 1.00 9.07  ? 243  PHE A CE1 1 
ATOM   1881 C  CE2 . PHE A 1 266 ? -8.199  0.124   12.305 1.00 8.88  ? 243  PHE A CE2 1 
ATOM   1882 C  CZ  . PHE A 1 266 ? -9.317  -0.526  12.708 1.00 9.37  ? 243  PHE A CZ  1 
ATOM   1883 N  N   . ASN A 1 267 ? -6.204  -1.903  6.143  1.00 6.60  ? 244  ASN A N   1 
ATOM   1884 C  CA  . ASN A 1 267 ? -5.508  -2.453  4.976  1.00 7.62  ? 244  ASN A CA  1 
ATOM   1885 C  C   . ASN A 1 267 ? -4.076  -1.970  4.913  1.00 7.10  ? 244  ASN A C   1 
ATOM   1886 O  O   . ASN A 1 267 ? -3.823  -0.758  4.863  1.00 7.66  ? 244  ASN A O   1 
ATOM   1887 C  CB  . ASN A 1 267 ? -6.228  -2.007  3.705  1.00 8.59  ? 244  ASN A CB  1 
ATOM   1888 C  CG  . ASN A 1 267 ? -7.580  -2.638  3.581  1.00 10.73 ? 244  ASN A CG  1 
ATOM   1889 O  OD1 . ASN A 1 267 ? -7.852  -3.661  4.200  1.00 11.83 ? 244  ASN A OD1 1 
ATOM   1890 N  ND2 . ASN A 1 267 ? -8.458  -1.970  2.852  1.00 13.29 ? 244  ASN A ND2 1 
ATOM   1891 N  N   . ASN A 1 268 ? -3.131  -2.897  5.033  1.00 7.36  ? 245  ASN A N   1 
ATOM   1892 C  CA  . ASN A 1 268 ? -1.721  -2.537  4.997  1.00 7.86  ? 245  ASN A CA  1 
ATOM   1893 C  C   . ASN A 1 268 ? -1.375  -1.507  6.072  1.00 7.42  ? 245  ASN A C   1 
ATOM   1894 O  O   . ASN A 1 268 ? -0.650  -0.538  5.835  1.00 8.53  ? 245  ASN A O   1 
ATOM   1895 C  CB  . ASN A 1 268 ? -1.285  -2.083  3.601  1.00 9.91  ? 245  ASN A CB  1 
ATOM   1896 C  CG  . ASN A 1 268 ? -1.576  -3.162  2.587  1.00 16.54 ? 245  ASN A CG  1 
ATOM   1897 O  OD1 . ASN A 1 268 ? -2.589  -3.075  1.871  1.00 24.78 ? 245  ASN A OD1 1 
ATOM   1898 N  ND2 . ASN A 1 268 ? -0.771  -4.190  2.584  1.00 20.31 ? 245  ASN A ND2 1 
ATOM   1899 N  N   . CYS A 1 269 ? -1.951  -1.698  7.256  1.00 6.50  ? 246  CYS A N   1 
ATOM   1900 C  CA  . CYS A 1 269 ? -1.694  -0.829  8.407  1.00 6.36  ? 246  CYS A CA  1 
ATOM   1901 C  C   . CYS A 1 269 ? -0.659  -1.467  9.325  1.00 6.30  ? 246  CYS A C   1 
ATOM   1902 O  O   . CYS A 1 269 ? -0.289  -2.647  9.155  1.00 7.39  ? 246  CYS A O   1 
ATOM   1903 C  CB  . CYS A 1 269 ? -2.972  -0.599  9.190  1.00 6.89  ? 246  CYS A CB  1 
ATOM   1904 S  SG  . CYS A 1 269 ? -4.190  0.420   8.300  1.00 7.46  ? 246  CYS A SG  1 
ATOM   1905 N  N   . GLU A 1 270 ? -0.190  -0.688  10.294 1.00 5.68  ? 247  GLU A N   1 
ATOM   1906 C  CA  . GLU A 1 270 ? 0.664   -1.209  11.363 1.00 5.56  ? 247  GLU A CA  1 
ATOM   1907 C  C   . GLU A 1 270 ? -0.047  -0.934  12.676 1.00 5.83  ? 247  GLU A C   1 
ATOM   1908 O  O   . GLU A 1 270 ? -0.402  0.220   12.937 1.00 6.69  ? 247  GLU A O   1 
ATOM   1909 C  CB  . GLU A 1 270 ? 2.054   -0.563  11.358 1.00 6.38  ? 247  GLU A CB  1 
ATOM   1910 C  CG  . GLU A 1 270 ? 2.795   -0.727  10.044 1.00 7.55  ? 247  GLU A CG  1 
ATOM   1911 C  CD  . GLU A 1 270 ? 4.286   -0.498  10.176 1.00 9.55  ? 247  GLU A CD  1 
ATOM   1912 O  OE1 . GLU A 1 270 ? 4.961   -0.526  9.133  1.00 12.16 ? 247  GLU A OE1 1 
ATOM   1913 O  OE2 . GLU A 1 270 ? 4.760   -0.388  11.300 1.00 9.75  ? 247  GLU A OE2 1 
ATOM   1914 N  N   . ILE A 1 271 ? -0.215  -1.965  13.516 1.00 5.58  ? 248  ILE A N   1 
ATOM   1915 C  CA  . ILE A 1 271 ? -0.888  -1.811  14.811 1.00 5.56  ? 248  ILE A CA  1 
ATOM   1916 C  C   . ILE A 1 271 ? 0.153   -2.200  15.862 1.00 5.15  ? 248  ILE A C   1 
ATOM   1917 O  O   . ILE A 1 271 ? 0.737   -3.281  15.767 1.00 5.98  ? 248  ILE A O   1 
ATOM   1918 C  CB  . ILE A 1 271 ? -2.138  -2.703  14.927 1.00 6.28  ? 248  ILE A CB  1 
ATOM   1919 C  CG1 . ILE A 1 271 ? -2.978  -2.772  13.627 1.00 6.66  ? 248  ILE A CG1 1 
ATOM   1920 C  CG2 . ILE A 1 271 ? -2.943  -2.288  16.145 1.00 6.53  ? 248  ILE A CG2 1 
ATOM   1921 C  CD1 . ILE A 1 271 ? -3.564  -1.457  13.193 1.00 7.38  ? 248  ILE A CD1 1 
ATOM   1922 N  N   . TYR A 1 272 ? 0.348   -1.316  16.845 1.00 4.81  ? 249  TYR A N   1 
ATOM   1923 C  CA  . TYR A 1 272 ? 1.347   -1.519  17.887 1.00 5.25  ? 249  TYR A CA  1 
ATOM   1924 C  C   . TYR A 1 272 ? 0.650   -1.746  19.218 1.00 4.91  ? 249  TYR A C   1 
ATOM   1925 O  O   . TYR A 1 272 ? -0.327  -1.069  19.552 1.00 5.43  ? 249  TYR A O   1 
ATOM   1926 C  CB  . TYR A 1 272 ? 2.172   -0.272  18.143 1.00 5.50  ? 249  TYR A CB  1 
ATOM   1927 C  CG  . TYR A 1 272 ? 3.193   0.154   17.120 1.00 5.58  ? 249  TYR A CG  1 
ATOM   1928 C  CD1 . TYR A 1 272 ? 3.078   -0.100  15.758 1.00 6.65  ? 249  TYR A CD1 1 
ATOM   1929 C  CD2 . TYR A 1 272 ? 4.339   0.813   17.543 1.00 6.13  ? 249  TYR A CD2 1 
ATOM   1930 C  CE1 . TYR A 1 272 ? 4.059   0.290   14.858 1.00 6.55  ? 249  TYR A CE1 1 
ATOM   1931 C  CE2 . TYR A 1 272 ? 5.336   1.189   16.658 1.00 6.10  ? 249  TYR A CE2 1 
ATOM   1932 C  CZ  . TYR A 1 272 ? 5.189   0.932   15.309 1.00 6.43  ? 249  TYR A CZ  1 
ATOM   1933 O  OH  . TYR A 1 272 ? 6.171   1.312   14.421 1.00 7.20  ? 249  TYR A OH  1 
ATOM   1934 N  N   . GLY A 1 273 ? 1.199   -2.636  20.036 1.00 4.57  ? 250  GLY A N   1 
ATOM   1935 C  CA  . GLY A 1 273 ? 0.764   -2.696  21.425 1.00 4.72  ? 250  GLY A CA  1 
ATOM   1936 C  C   . GLY A 1 273 ? 1.324   -3.851  22.226 1.00 4.85  ? 250  GLY A C   1 
ATOM   1937 O  O   . GLY A 1 273 ? 2.154   -4.644  21.742 1.00 5.17  ? 250  GLY A O   1 
ATOM   1938 N  N   . ALA A 1 274 ? 0.810   -3.938  23.443 1.00 5.42  ? 251  ALA A N   1 
ATOM   1939 C  CA  . ALA A 1 274 ? 1.204   -4.928  24.422 1.00 5.39  ? 251  ALA A CA  1 
ATOM   1940 C  C   . ALA A 1 274 ? -0.078  -5.646  24.880 1.00 5.14  ? 251  ALA A C   1 
ATOM   1941 O  O   . ALA A 1 274 ? -0.569  -6.510  24.141 1.00 4.90  ? 251  ALA A O   1 
ATOM   1942 C  CB  . ALA A 1 274 ? 2.033   -4.272  25.506 1.00 5.81  ? 251  ALA A CB  1 
ATOM   1943 N  N   . VAL A 1 275 ? -0.629  -5.300  26.027 1.00 5.21  ? 252  VAL A N   1 
ATOM   1944 C  CA  . VAL A 1 275 ? -1.801  -6.006  26.501 1.00 5.43  ? 252  VAL A CA  1 
ATOM   1945 C  C   . VAL A 1 275 ? -3.035  -5.602  25.685 1.00 5.19  ? 252  VAL A C   1 
ATOM   1946 O  O   . VAL A 1 275 ? -3.473  -4.445  25.724 1.00 5.35  ? 252  VAL A O   1 
ATOM   1947 C  CB  . VAL A 1 275 ? -1.988  -5.746  28.006 1.00 5.52  ? 252  VAL A CB  1 
ATOM   1948 C  CG1 . VAL A 1 275 ? -3.351  -6.221  28.494 1.00 5.94  ? 252  VAL A CG1 1 
ATOM   1949 C  CG2 . VAL A 1 275 ? -0.879  -6.447  28.798 1.00 6.49  ? 252  VAL A CG2 1 
ATOM   1950 N  N   . ASP A 1 276 ? -3.662  -6.607  25.086 1.00 5.26  ? 253  ASP A N   1 
ATOM   1951 C  CA  . ASP A 1 276 ? -5.017  -6.539  24.528 1.00 5.27  ? 253  ASP A CA  1 
ATOM   1952 C  C   . ASP A 1 276 ? -5.111  -5.380  23.538 1.00 4.94  ? 253  ASP A C   1 
ATOM   1953 O  O   . ASP A 1 276 ? -6.038  -4.563  23.589 1.00 5.08  ? 253  ASP A O   1 
ATOM   1954 C  CB  . ASP A 1 276 ? -6.056  -6.391  25.622 1.00 5.75  ? 253  ASP A CB  1 
ATOM   1955 C  CG  . ASP A 1 276 ? -6.099  -7.543  26.621 1.00 6.48  ? 253  ASP A CG  1 
ATOM   1956 O  OD1 . ASP A 1 276 ? -5.531  -8.618  26.345 1.00 6.62  ? 253  ASP A OD1 1 
ATOM   1957 O  OD2 . ASP A 1 276 ? -6.716  -7.302  27.689 1.00 7.53  ? 253  ASP A OD2 1 
ATOM   1958 N  N   . TYR A 1 277 ? -4.136  -5.257  22.632 1.00 5.09  ? 254  TYR A N   1 
ATOM   1959 C  CA  . TYR A 1 277 ? -4.017  -3.994  21.829 1.00 4.97  ? 254  TYR A CA  1 
ATOM   1960 C  C   . TYR A 1 277 ? -5.030  -3.818  20.712 1.00 4.84  ? 254  TYR A C   1 
ATOM   1961 O  O   . TYR A 1 277 ? -5.149  -2.710  20.228 1.00 5.19  ? 254  TYR A O   1 
ATOM   1962 C  CB  . TYR A 1 277 ? -2.546  -3.707  21.496 1.00 4.73  ? 254  TYR A CB  1 
ATOM   1963 C  CG  . TYR A 1 277 ? -1.857  -4.540  20.428 1.00 5.08  ? 254  TYR A CG  1 
ATOM   1964 C  CD1 . TYR A 1 277 ? -2.023  -4.260  19.081 1.00 5.26  ? 254  TYR A CD1 1 
ATOM   1965 C  CD2 . TYR A 1 277 ? -0.975  -5.551  20.782 1.00 5.34  ? 254  TYR A CD2 1 
ATOM   1966 C  CE1 . TYR A 1 277 ? -1.348  -4.980  18.112 1.00 5.42  ? 254  TYR A CE1 1 
ATOM   1967 C  CE2 . TYR A 1 277 ? -0.273  -6.261  19.824 1.00 4.97  ? 254  TYR A CE2 1 
ATOM   1968 C  CZ  . TYR A 1 277 ? -0.467  -5.976  18.486 1.00 5.28  ? 254  TYR A CZ  1 
ATOM   1969 O  OH  . TYR A 1 277 ? 0.199   -6.660  17.518 1.00 5.87  ? 254  TYR A OH  1 
ATOM   1970 N  N   . ILE A 1 278 ? -5.697  -4.884  20.329 1.00 4.50  ? 255  ILE A N   1 
ATOM   1971 C  CA  . ILE A 1 278 ? -6.858  -4.775  19.471 1.00 4.66  ? 255  ILE A CA  1 
ATOM   1972 C  C   . ILE A 1 278 ? -8.024  -5.389  20.248 1.00 4.75  ? 255  ILE A C   1 
ATOM   1973 O  O   . ILE A 1 278 ? -7.947  -6.595  20.549 1.00 4.98  ? 255  ILE A O   1 
ATOM   1974 C  CB  . ILE A 1 278 ? -6.689  -5.482  18.120 1.00 4.75  ? 255  ILE A CB  1 
ATOM   1975 C  CG1 . ILE A 1 278 ? -5.452  -5.020  17.396 1.00 5.06  ? 255  ILE A CG1 1 
ATOM   1976 C  CG2 . ILE A 1 278 ? -7.962  -5.330  17.284 1.00 5.49  ? 255  ILE A CG2 1 
ATOM   1977 C  CD1 . ILE A 1 278 ? -5.069  -5.837  16.184 1.00 5.60  ? 255  ILE A CD1 1 
ATOM   1978 N  N   . PHE A 1 279 ? -9.045  -4.612  20.613 1.00 4.66  ? 256  PHE A N   1 
ATOM   1979 C  CA  . PHE A 1 279 ? -10.035 -5.152  21.534 1.00 5.10  ? 256  PHE A CA  1 
ATOM   1980 C  C   . PHE A 1 279 ? -11.401 -4.578  21.196 1.00 4.78  ? 256  PHE A C   1 
ATOM   1981 O  O   . PHE A 1 279 ? -11.549 -3.576  20.532 1.00 5.36  ? 256  PHE A O   1 
ATOM   1982 C  CB  . PHE A 1 279 ? -9.639  -4.939  23.012 1.00 5.24  ? 256  PHE A CB  1 
ATOM   1983 C  CG  . PHE A 1 279 ? -9.773  -3.539  23.565 1.00 5.39  ? 256  PHE A CG  1 
ATOM   1984 C  CD1 . PHE A 1 279 ? -8.979  -2.493  23.091 1.00 5.59  ? 256  PHE A CD1 1 
ATOM   1985 C  CD2 . PHE A 1 279 ? -10.684 -3.273  24.571 1.00 5.57  ? 256  PHE A CD2 1 
ATOM   1986 C  CE1 . PHE A 1 279 ? -9.141  -1.225  23.599 1.00 5.81  ? 256  PHE A CE1 1 
ATOM   1987 C  CE2 . PHE A 1 279 ? -10.780 -2.011  25.103 1.00 6.02  ? 256  PHE A CE2 1 
ATOM   1988 C  CZ  . PHE A 1 279 ? -10.024 -0.992  24.632 1.00 6.05  ? 256  PHE A CZ  1 
ATOM   1989 N  N   . GLY A 1 280 ? -12.428 -5.256  21.720 1.00 4.82  ? 257  GLY A N   1 
ATOM   1990 C  CA  . GLY A 1 280 ? -13.805 -4.885  21.484 1.00 4.82  ? 257  GLY A CA  1 
ATOM   1991 C  C   . GLY A 1 280 ? -14.538 -5.838  20.549 1.00 5.23  ? 257  GLY A C   1 
ATOM   1992 O  O   . GLY A 1 280 ? -13.967 -6.789  20.004 1.00 5.60  ? 257  GLY A O   1 
ATOM   1993 N  N   . GLY A 1 281 ? -15.818 -5.552  20.342 1.00 5.25  ? 258  GLY A N   1 
ATOM   1994 C  CA  . GLY A 1 281 ? -16.695 -6.448  19.608 1.00 5.37  ? 258  GLY A CA  1 
ATOM   1995 C  C   . GLY A 1 281 ? -16.821 -6.165  18.119 1.00 5.27  ? 258  GLY A C   1 
ATOM   1996 O  O   . GLY A 1 281 ? -17.643 -6.828  17.496 1.00 5.71  ? 258  GLY A O   1 
ATOM   1997 N  N   . MET A 1 282 ? -16.020 -5.304  17.520 1.00 5.36  ? 259  MET A N   1 
ATOM   1998 C  CA  . MET A 1 282 ? -16.162 -5.026  16.099 1.00 5.56  ? 259  MET A CA  1 
ATOM   1999 C  C   . MET A 1 282 ? -15.970 -6.276  15.251 1.00 5.84  ? 259  MET A C   1 
ATOM   2000 O  O   . MET A 1 282 ? -15.275 -7.235  15.625 1.00 5.96  ? 259  MET A O   1 
ATOM   2001 C  CB  . MET A 1 282 ? -15.172 -3.954  15.672 1.00 6.06  ? 259  MET A CB  1 
ATOM   2002 C  CG  . MET A 1 282 ? -13.712 -4.241  16.011 1.00 6.44  ? 259  MET A CG  1 
ATOM   2003 S  SD  . MET A 1 282 ? -12.637 -3.037  15.202 1.00 7.33  ? 259  MET A SD  1 
ATOM   2004 C  CE  . MET A 1 282 ? -11.070 -3.455  15.945 1.00 8.58  ? 259  MET A CE  1 
ATOM   2005 N  N   . THR A 1 283 ? -16.554 -6.210  14.038 1.00 5.43  ? 260  THR A N   1 
ATOM   2006 C  CA  . THR A 1 283 ? -16.317 -7.177  12.983 1.00 5.97  ? 260  THR A CA  1 
ATOM   2007 C  C   . THR A 1 283 ? -15.270 -6.554  12.079 1.00 6.36  ? 260  THR A C   1 
ATOM   2008 O  O   . THR A 1 283 ? -15.545 -5.665  11.277 1.00 6.32  ? 260  THR A O   1 
ATOM   2009 C  CB  . THR A 1 283 ? -17.592 -7.534  12.233 1.00 5.90  ? 260  THR A CB  1 
ATOM   2010 O  OG1 . THR A 1 283 ? -18.564 -8.068  13.142 1.00 7.19  ? 260  THR A OG1 1 
ATOM   2011 C  CG2 . THR A 1 283 ? -17.297 -8.508  11.114 1.00 6.65  ? 260  THR A CG2 1 
ATOM   2012 N  N   . ALA A 1 284 ? -14.025 -6.955  12.293 1.00 6.72  ? 261  ALA A N   1 
ATOM   2013 C  CA  . ALA A 1 284 ? -12.869 -6.265  11.723 1.00 6.90  ? 261  ALA A CA  1 
ATOM   2014 C  C   . ALA A 1 284 ? -12.106 -7.155  10.764 1.00 6.84  ? 261  ALA A C   1 
ATOM   2015 O  O   . ALA A 1 284 ? -11.946 -8.347  11.020 1.00 8.31  ? 261  ALA A O   1 
ATOM   2016 C  CB  . ALA A 1 284 ? -11.920 -5.818  12.837 1.00 6.90  ? 261  ALA A CB  1 
ATOM   2017 N  N   . ILE A 1 285 ? -11.540 -6.544  9.736  1.00 6.36  ? 262  ILE A N   1 
ATOM   2018 C  CA  . ILE A 1 285 ? -10.549 -7.180  8.879  1.00 6.38  ? 262  ILE A CA  1 
ATOM   2019 C  C   . ILE A 1 285 ? -9.244  -6.434  9.060  1.00 6.16  ? 262  ILE A C   1 
ATOM   2020 O  O   . ILE A 1 285 ? -9.185  -5.244  8.845  1.00 6.49  ? 262  ILE A O   1 
ATOM   2021 C  CB  . ILE A 1 285 ? -10.977 -7.170  7.404  1.00 7.03  ? 262  ILE A CB  1 
ATOM   2022 C  CG1 . ILE A 1 285 ? -12.254 -7.980  7.185  1.00 7.17  ? 262  ILE A CG1 1 
ATOM   2023 C  CG2 . ILE A 1 285 ? -9.850  -7.692  6.523  1.00 8.25  ? 262  ILE A CG2 1 
ATOM   2024 C  CD1 . ILE A 1 285 ? -12.893 -7.743  5.845  1.00 7.81  ? 262  ILE A CD1 1 
ATOM   2025 N  N   . PHE A 1 286 ? -8.184  -7.157  9.403  1.00 5.52  ? 263  PHE A N   1 
ATOM   2026 C  CA  . PHE A 1 286 ? -6.815  -6.657  9.381  1.00 5.64  ? 263  PHE A CA  1 
ATOM   2027 C  C   . PHE A 1 286 ? -6.143  -7.348  8.216  1.00 6.04  ? 263  PHE A C   1 
ATOM   2028 O  O   . PHE A 1 286 ? -5.819  -8.529  8.316  1.00 6.45  ? 263  PHE A O   1 
ATOM   2029 C  CB  . PHE A 1 286 ? -6.109  -6.914  10.715 1.00 6.38  ? 263  PHE A CB  1 
ATOM   2030 C  CG  . PHE A 1 286 ? -6.683  -6.079  11.843 1.00 6.23  ? 263  PHE A CG  1 
ATOM   2031 C  CD1 . PHE A 1 286 ? -7.814  -6.470  12.538 1.00 5.95  ? 263  PHE A CD1 1 
ATOM   2032 C  CD2 . PHE A 1 286 ? -6.139  -4.833  12.128 1.00 6.22  ? 263  PHE A CD2 1 
ATOM   2033 C  CE1 . PHE A 1 286 ? -8.338  -5.657  13.511 1.00 6.18  ? 263  PHE A CE1 1 
ATOM   2034 C  CE2 . PHE A 1 286 ? -6.689  -4.019  13.118 1.00 6.43  ? 263  PHE A CE2 1 
ATOM   2035 C  CZ  . PHE A 1 286 ? -7.794  -4.450  13.802 1.00 5.98  ? 263  PHE A CZ  1 
ATOM   2036 N  N   . TYR A 1 287 ? -6.039  -6.627  7.096  1.00 6.57  ? 264  TYR A N   1 
ATOM   2037 C  CA  . TYR A 1 287 ? -5.557  -7.190  5.846  1.00 6.40  ? 264  TYR A CA  1 
ATOM   2038 C  C   . TYR A 1 287 ? -4.091  -6.799  5.669  1.00 6.59  ? 264  TYR A C   1 
ATOM   2039 O  O   . TYR A 1 287 ? -3.780  -5.617  5.510  1.00 6.79  ? 264  TYR A O   1 
ATOM   2040 C  CB  . TYR A 1 287 ? -6.400  -6.630  4.704  1.00 7.13  ? 264  TYR A CB  1 
ATOM   2041 C  CG  . TYR A 1 287 ? -5.944  -7.113  3.330  1.00 8.45  ? 264  TYR A CG  1 
ATOM   2042 C  CD1 . TYR A 1 287 ? -6.288  -8.363  2.847  1.00 9.66  ? 264  TYR A CD1 1 
ATOM   2043 C  CD2 . TYR A 1 287 ? -5.189  -6.283  2.548  1.00 8.68  ? 264  TYR A CD2 1 
ATOM   2044 C  CE1 . TYR A 1 287 ? -5.839  -8.797  1.593  1.00 10.82 ? 264  TYR A CE1 1 
ATOM   2045 C  CE2 . TYR A 1 287 ? -4.758  -6.694  1.295  1.00 10.13 ? 264  TYR A CE2 1 
ATOM   2046 C  CZ  . TYR A 1 287 ? -5.091  -7.938  0.846  1.00 11.11 ? 264  TYR A CZ  1 
ATOM   2047 O  OH  . TYR A 1 287 ? -4.670  -8.298  -0.445 1.00 14.73 ? 264  TYR A OH  1 
ATOM   2048 N  N   . GLN A 1 288 ? -3.224  -7.781  5.722  1.00 6.82  ? 265  GLN A N   1 
ATOM   2049 C  CA  . GLN A 1 288 ? -1.798  -7.581  5.449  1.00 7.66  ? 265  GLN A CA  1 
ATOM   2050 C  C   . GLN A 1 288 ? -1.213  -6.481  6.320  1.00 7.16  ? 265  GLN A C   1 
ATOM   2051 O  O   . GLN A 1 288 ? -0.477  -5.622  5.872  1.00 8.09  ? 265  GLN A O   1 
ATOM   2052 C  CB  . GLN A 1 288 ? -1.533  -7.304  3.965  1.00 8.69  ? 265  GLN A CB  1 
ATOM   2053 C  CG  . GLN A 1 288 ? -2.021  -8.483  3.136  1.00 10.67 ? 265  GLN A CG  1 
ATOM   2054 C  CD  . GLN A 1 288 ? -1.604  -8.479  1.691  1.00 12.86 ? 265  GLN A CD  1 
ATOM   2055 O  OE1 . GLN A 1 288 ? -1.205  -7.440  1.167  1.00 13.43 ? 265  GLN A OE1 1 
ATOM   2056 N  NE2 . GLN A 1 288 ? -1.785  -9.633  1.046  1.00 13.79 ? 265  GLN A NE2 1 
ATOM   2057 N  N   . CYS A 1 289 ? -1.544  -6.562  7.606  1.00 6.35  ? 266  CYS A N   1 
ATOM   2058 C  CA  . CYS A 1 289 ? -1.044  -5.617  8.588  1.00 6.11  ? 266  CYS A CA  1 
ATOM   2059 C  C   . CYS A 1 289 ? 0.193   -6.148  9.298  1.00 5.66  ? 266  CYS A C   1 
ATOM   2060 O  O   . CYS A 1 289 ? 0.381   -7.345  9.477  1.00 6.83  ? 266  CYS A O   1 
ATOM   2061 C  CB  . CYS A 1 289 ? -2.088  -5.283  9.661  1.00 6.43  ? 266  CYS A CB  1 
ATOM   2062 S  SG  . CYS A 1 289 ? -3.532  -4.389  8.998  1.00 7.13  ? 266  CYS A SG  1 
ATOM   2063 N  N   . GLU A 1 290 ? 1.005   -5.188  9.743  1.00 5.71  ? 267  GLU A N   1 
ATOM   2064 C  CA  . GLU A 1 290 ? 2.103   -5.500  10.684 1.00 6.04  ? 267  GLU A CA  1 
ATOM   2065 C  C   . GLU A 1 290 ? 1.502   -5.396  12.085 1.00 6.61  ? 267  GLU A C   1 
ATOM   2066 O  O   . GLU A 1 290 ? 0.924   -4.385  12.415 1.00 7.44  ? 267  GLU A O   1 
ATOM   2067 C  CB  . GLU A 1 290 ? 3.217   -4.458  10.561 1.00 6.82  ? 267  GLU A CB  1 
ATOM   2068 C  CG  . GLU A 1 290 ? 3.805   -4.369  9.152  1.00 7.70  ? 267  GLU A CG  1 
ATOM   2069 C  CD  . GLU A 1 290 ? 4.433   -5.668  8.690  1.00 9.36  ? 267  GLU A CD  1 
ATOM   2070 O  OE1 . GLU A 1 290 ? 5.406   -6.087  9.320  1.00 10.57 ? 267  GLU A OE1 1 
ATOM   2071 O  OE2 . GLU A 1 290 ? 3.926   -6.270  7.734  1.00 13.77 ? 267  GLU A OE2 1 
ATOM   2072 N  N   . LEU A 1 291 ? 1.660   -6.434  12.864 1.00 6.20  ? 268  LEU A N   1 
ATOM   2073 C  CA  . LEU A 1 291 ? 1.158   -6.507  14.238 1.00 5.46  ? 268  LEU A CA  1 
ATOM   2074 C  C   . LEU A 1 291 ? 2.400   -6.489  15.112 1.00 5.45  ? 268  LEU A C   1 
ATOM   2075 O  O   . LEU A 1 291 ? 3.078   -7.513  15.235 1.00 5.38  ? 268  LEU A O   1 
ATOM   2076 C  CB  . LEU A 1 291 ? 0.315   -7.762  14.391 1.00 5.47  ? 268  LEU A CB  1 
ATOM   2077 C  CG  . LEU A 1 291 ? -0.874  -7.862  13.420 1.00 6.07  ? 268  LEU A CG  1 
ATOM   2078 C  CD1 . LEU A 1 291 ? -1.550  -9.204  13.610 1.00 6.51  ? 268  LEU A CD1 1 
ATOM   2079 C  CD2 . LEU A 1 291 ? -1.887  -6.794  13.620 1.00 6.73  ? 268  LEU A CD2 1 
ATOM   2080 N  N   . LYS A 1 292 ? 2.708   -5.313  15.659 1.00 5.44  ? 269  LYS A N   1 
ATOM   2081 C  CA  . LYS A 1 292 ? 3.969   -5.117  16.333 1.00 5.62  ? 269  LYS A CA  1 
ATOM   2082 C  C   . LYS A 1 292 ? 3.844   -5.091  17.843 1.00 5.19  ? 269  LYS A C   1 
ATOM   2083 O  O   . LYS A 1 292 ? 3.201   -4.225  18.429 1.00 5.66  ? 269  LYS A O   1 
ATOM   2084 C  CB  . LYS A 1 292 ? 4.635   -3.790  15.936 1.00 6.63  ? 269  LYS A CB  1 
ATOM   2085 C  CG  . LYS A 1 292 ? 5.105   -3.751  14.488 1.00 8.82  ? 269  LYS A CG  1 
ATOM   2086 C  CD  . LYS A 1 292 ? 6.005   -2.599  14.069 1.00 9.87  ? 269  LYS A CD  1 
ATOM   2087 C  CE  . LYS A 1 292 ? 6.528   -2.827  12.696 1.00 11.64 ? 269  LYS A CE  1 
ATOM   2088 N  NZ  . LYS A 1 292 ? 7.160   -1.617  12.165 1.00 11.04 ? 269  LYS A NZ  1 
ATOM   2089 N  N   . PHE A 1 293 ? 4.471   -6.067  18.502 1.00 5.12  ? 270  PHE A N   1 
ATOM   2090 C  CA  . PHE A 1 293 ? 4.582   -6.077  19.945 1.00 5.06  ? 270  PHE A CA  1 
ATOM   2091 C  C   . PHE A 1 293 ? 5.438   -4.917  20.420 1.00 5.29  ? 270  PHE A C   1 
ATOM   2092 O  O   . PHE A 1 293 ? 6.598   -4.792  19.978 1.00 6.13  ? 270  PHE A O   1 
ATOM   2093 C  CB  . PHE A 1 293 ? 5.120   -7.386  20.463 1.00 4.80  ? 270  PHE A CB  1 
ATOM   2094 C  CG  . PHE A 1 293 ? 4.151   -8.547  20.474 1.00 5.20  ? 270  PHE A CG  1 
ATOM   2095 C  CD1 . PHE A 1 293 ? 2.895   -8.441  21.050 1.00 5.40  ? 270  PHE A CD1 1 
ATOM   2096 C  CD2 . PHE A 1 293 ? 4.502   -9.774  19.926 1.00 5.26  ? 270  PHE A CD2 1 
ATOM   2097 C  CE1 . PHE A 1 293 ? 2.041   -9.512  21.043 1.00 5.47  ? 270  PHE A CE1 1 
ATOM   2098 C  CE2 . PHE A 1 293 ? 3.648   -10.845 19.952 1.00 5.48  ? 270  PHE A CE2 1 
ATOM   2099 C  CZ  . PHE A 1 293 ? 2.413   -10.715 20.485 1.00 5.48  ? 270  PHE A CZ  1 
ATOM   2100 N  N   . ASN A 1 294 ? 4.874   -4.098  21.283 1.00 5.46  ? 271  ASN A N   1 
ATOM   2101 C  CA  . ASN A 1 294 ? 5.449   -2.875  21.835 1.00 5.32  ? 271  ASN A CA  1 
ATOM   2102 C  C   . ASN A 1 294 ? 5.604   -3.077  23.335 1.00 5.36  ? 271  ASN A C   1 
ATOM   2103 O  O   . ASN A 1 294 ? 4.728   -2.682  24.122 1.00 5.69  ? 271  ASN A O   1 
ATOM   2104 C  CB  . ASN A 1 294 ? 4.548   -1.715  21.467 1.00 5.36  ? 271  ASN A CB  1 
ATOM   2105 C  CG  . ASN A 1 294 ? 5.163   -0.390  21.789 1.00 5.84  ? 271  ASN A CG  1 
ATOM   2106 O  OD1 . ASN A 1 294 ? 6.384   -0.330  22.041 1.00 7.43  ? 271  ASN A OD1 1 
ATOM   2107 N  ND2 . ASN A 1 294 ? 4.411   0.676   21.749 1.00 6.05  ? 271  ASN A ND2 1 
ATOM   2108 N  N   . THR A 1 295 ? 6.668   -3.773  23.735 1.00 5.88  ? 272  THR A N   1 
ATOM   2109 C  CA  . THR A 1 295 ? 6.897   -4.232  25.096 1.00 6.05  ? 272  THR A CA  1 
ATOM   2110 C  C   . THR A 1 295 ? 8.310   -3.862  25.482 1.00 6.07  ? 272  THR A C   1 
ATOM   2111 O  O   . THR A 1 295 ? 9.135   -3.473  24.654 1.00 7.41  ? 272  THR A O   1 
ATOM   2112 C  CB  . THR A 1 295 ? 6.750   -5.729  25.178 1.00 6.53  ? 272  THR A CB  1 
ATOM   2113 O  OG1 . THR A 1 295 ? 7.743   -6.359  24.347 1.00 6.97  ? 272  THR A OG1 1 
ATOM   2114 C  CG2 . THR A 1 295 ? 5.346   -6.198  24.845 1.00 7.23  ? 272  THR A CG2 1 
ATOM   2115 N  N   . THR A 1 296 ? 8.604   -3.956  26.778 1.00 6.34  ? 273  THR A N   1 
ATOM   2116 C  CA  . THR A 1 296 ? 9.934   -3.705  27.363 1.00 6.09  ? 273  THR A CA  1 
ATOM   2117 C  C   . THR A 1 296 ? 10.527  -5.000  27.882 1.00 6.41  ? 273  THR A C   1 
ATOM   2118 O  O   . THR A 1 296 ? 9.889   -6.050  27.958 1.00 6.44  ? 273  THR A O   1 
ATOM   2119 C  CB  . THR A 1 296 ? 9.848   -2.700  28.501 1.00 6.36  ? 273  THR A CB  1 
ATOM   2120 O  OG1 . THR A 1 296 ? 9.203   -3.313  29.622 1.00 6.41  ? 273  THR A OG1 1 
ATOM   2121 C  CG2 . THR A 1 296 ? 9.226   -1.379  28.117 1.00 6.72  ? 273  THR A CG2 1 
ATOM   2122 N  N   . ASP A 1 297 ? 11.792  -4.869  28.339 1.00 6.64  ? 274  ASP A N   1 
ATOM   2123 C  CA  . ASP A 1 297 ? 12.544  -5.971  28.904 1.00 7.21  ? 274  ASP A CA  1 
ATOM   2124 C  C   . ASP A 1 297 ? 11.946  -6.547  30.184 1.00 7.02  ? 274  ASP A C   1 
ATOM   2125 O  O   . ASP A 1 297 ? 12.316  -7.650  30.583 1.00 8.16  ? 274  ASP A O   1 
ATOM   2126 C  CB  . ASP A 1 297 ? 13.959  -5.503  29.233 1.00 7.72  ? 274  ASP A CB  1 
ATOM   2127 C  CG  . ASP A 1 297 ? 14.806  -5.040  28.060 1.00 7.71  ? 274  ASP A CG  1 
ATOM   2128 O  OD1 . ASP A 1 297 ? 14.529  -5.398  26.928 1.00 6.87  ? 274  ASP A OD1 1 
ATOM   2129 O  OD2 . ASP A 1 297 ? 15.760  -4.249  28.367 1.00 9.56  ? 274  ASP A OD2 1 
ATOM   2130 N  N   . ASN A 1 298 ? 11.073  -5.825  30.864 1.00 7.36  ? 275  ASN A N   1 
ATOM   2131 C  CA  . ASN A 1 298 ? 10.510  -6.332  32.097 1.00 7.34  ? 275  ASN A CA  1 
ATOM   2132 C  C   . ASN A 1 298 ? 9.886   -7.697  31.857 1.00 7.30  ? 275  ASN A C   1 
ATOM   2133 O  O   . ASN A 1 298 ? 9.164   -7.911  30.888 1.00 7.01  ? 275  ASN A O   1 
ATOM   2134 C  CB  . ASN A 1 298 ? 9.502   -5.334  32.649 1.00 8.09  ? 275  ASN A CB  1 
ATOM   2135 C  CG  . ASN A 1 298 ? 8.835   -5.818  33.914 1.00 10.13 ? 275  ASN A CG  1 
ATOM   2136 O  OD1 . ASN A 1 298 ? 7.886   -6.593  33.897 1.00 11.41 ? 275  ASN A OD1 1 
ATOM   2137 N  ND2 . ASN A 1 298 ? 9.399   -5.363  35.014 1.00 14.85 ? 275  ASN A ND2 1 
ATOM   2138 N  N   . LYS A 1 299 ? 10.129  -8.635  32.786 1.00 7.73  ? 276  LYS A N   1 
ATOM   2139 C  CA  . LYS A 1 299 ? 9.755   -10.020 32.575 1.00 9.17  ? 276  LYS A CA  1 
ATOM   2140 C  C   . LYS A 1 299 ? 8.245   -10.224 32.485 1.00 9.39  ? 276  LYS A C   1 
ATOM   2141 O  O   . LYS A 1 299 ? 7.825   -11.197 31.844 1.00 10.31 ? 276  LYS A O   1 
ATOM   2142 C  CB  . LYS A 1 299 ? 10.322  -10.909 33.678 1.00 12.08 ? 276  LYS A CB  1 
ATOM   2143 C  CG  . LYS A 1 299 ? 9.769   -10.673 35.042 1.00 13.64 ? 276  LYS A CG  1 
ATOM   2144 C  CD  . LYS A 1 299 ? 10.476  -11.588 36.048 1.00 20.34 ? 276  LYS A CD  1 
ATOM   2145 C  CE  . LYS A 1 299 ? 9.769   -11.598 37.338 0.70 22.81 ? 276  LYS A CE  1 
ATOM   2146 N  NZ  . LYS A 1 299 ? 8.498   -12.324 37.334 0.50 26.02 ? 276  LYS A NZ  1 
ATOM   2147 N  N   . ASN A 1 300 ? 7.457   -9.313  33.069 1.00 8.07  ? 277  ASN A N   1 
ATOM   2148 C  CA  . ASN A 1 300 ? 5.968   -9.407  33.071 1.00 9.14  ? 277  ASN A CA  1 
ATOM   2149 C  C   . ASN A 1 300 ? 5.345   -8.598  31.917 1.00 8.16  ? 277  ASN A C   1 
ATOM   2150 O  O   . ASN A 1 300 ? 4.140   -8.560  31.819 1.00 9.28  ? 277  ASN A O   1 
ATOM   2151 C  CB  . ASN A 1 300 ? 5.444   -9.010  34.448 1.00 11.51 ? 277  ASN A CB  1 
ATOM   2152 C  CG  . ASN A 1 300 ? 5.910   -9.991  35.496 1.00 13.72 ? 277  ASN A CG  1 
ATOM   2153 O  OD1 . ASN A 1 300 ? 5.845   -11.202 35.280 1.00 16.28 ? 277  ASN A OD1 1 
ATOM   2154 N  ND2 . ASN A 1 300 ? 6.443   -9.488  36.596 1.00 21.48 ? 277  ASN A ND2 1 
ATOM   2155 N  N   . ASP A 1 301 ? 6.168   -8.012  31.042 1.00 6.95  ? 278  ASP A N   1 
ATOM   2156 C  CA  . ASP A 1 301 ? 5.663   -7.161  29.971 1.00 6.61  ? 278  ASP A CA  1 
ATOM   2157 C  C   . ASP A 1 301 ? 5.479   -8.017  28.725 1.00 6.12  ? 278  ASP A C   1 
ATOM   2158 O  O   . ASP A 1 301 ? 6.364   -8.108  27.872 1.00 6.71  ? 278  ASP A O   1 
ATOM   2159 C  CB  . ASP A 1 301 ? 6.560   -5.964  29.800 1.00 6.59  ? 278  ASP A CB  1 
ATOM   2160 C  CG  . ASP A 1 301 ? 5.976   -4.812  29.015 1.00 6.55  ? 278  ASP A CG  1 
ATOM   2161 O  OD1 . ASP A 1 301 ? 4.849   -4.992  28.436 1.00 8.05  ? 278  ASP A OD1 1 
ATOM   2162 O  OD2 . ASP A 1 301 ? 6.649   -3.786  28.874 1.00 6.44  ? 278  ASP A OD2 1 
ATOM   2163 N  N   . VAL A 1 302 ? 4.315   -8.651  28.683 1.00 6.13  ? 279  VAL A N   1 
ATOM   2164 C  CA  . VAL A 1 302 ? 3.924   -9.619  27.672 1.00 6.48  ? 279  VAL A CA  1 
ATOM   2165 C  C   . VAL A 1 302 ? 2.777   -9.050  26.851 1.00 6.25  ? 279  VAL A C   1 
ATOM   2166 O  O   . VAL A 1 302 ? 1.855   -8.452  27.427 1.00 7.73  ? 279  VAL A O   1 
ATOM   2167 C  CB  . VAL A 1 302 ? 3.540   -10.959 28.318 1.00 7.20  ? 279  VAL A CB  1 
ATOM   2168 C  CG1 . VAL A 1 302 ? 3.136   -11.986 27.263 1.00 7.81  ? 279  VAL A CG1 1 
ATOM   2169 C  CG2 . VAL A 1 302 ? 4.649   -11.518 29.220 1.00 8.46  ? 279  VAL A CG2 1 
ATOM   2170 N  N   . GLY A 1 303 ? 2.776   -9.239  25.558 1.00 5.74  ? 280  GLY A N   1 
ATOM   2171 C  CA  . GLY A 1 303 ? 1.695   -8.769  24.701 1.00 5.37  ? 280  GLY A CA  1 
ATOM   2172 C  C   . GLY A 1 303 ? 0.666   -9.836  24.355 1.00 5.47  ? 280  GLY A C   1 
ATOM   2173 O  O   . GLY A 1 303 ? 0.978   -11.018 24.253 1.00 6.13  ? 280  GLY A O   1 
ATOM   2174 N  N   . TYR A 1 304 ? -0.570  -9.365  24.144 1.00 5.66  ? 281  TYR A N   1 
ATOM   2175 C  CA  . TYR A 1 304 ? -1.671  -10.209 23.699 1.00 5.49  ? 281  TYR A CA  1 
ATOM   2176 C  C   . TYR A 1 304 ? -2.354  -9.417  22.592 1.00 5.11  ? 281  TYR A C   1 
ATOM   2177 O  O   . TYR A 1 304 ? -2.863  -8.318  22.845 1.00 5.91  ? 281  TYR A O   1 
ATOM   2178 C  CB  . TYR A 1 304 ? -2.691  -10.504 24.814 1.00 5.85  ? 281  TYR A CB  1 
ATOM   2179 C  CG  . TYR A 1 304 ? -2.130  -10.736 26.197 1.00 7.16  ? 281  TYR A CG  1 
ATOM   2180 C  CD1 . TYR A 1 304 ? -1.266  -11.779 26.487 1.00 7.08  ? 281  TYR A CD1 1 
ATOM   2181 C  CD2 . TYR A 1 304 ? -2.510  -9.923  27.240 1.00 8.14  ? 281  TYR A CD2 1 
ATOM   2182 C  CE1 . TYR A 1 304 ? -0.781  -11.994 27.760 1.00 7.94  ? 281  TYR A CE1 1 
ATOM   2183 C  CE2 . TYR A 1 304 ? -1.963  -10.073 28.507 1.00 9.25  ? 281  TYR A CE2 1 
ATOM   2184 C  CZ  . TYR A 1 304 ? -1.138  -11.142 28.752 1.00 9.20  ? 281  TYR A CZ  1 
ATOM   2185 O  OH  . TYR A 1 304 ? -0.655  -11.363 30.035 1.00 11.93 ? 281  TYR A OH  1 
ATOM   2186 N  N   . ILE A 1 305 ? -2.322  -9.902  21.359 1.00 5.12  ? 282  ILE A N   1 
ATOM   2187 C  CA  . ILE A 1 305 ? -2.724  -9.054  20.228 1.00 4.81  ? 282  ILE A CA  1 
ATOM   2188 C  C   . ILE A 1 305 ? -4.196  -8.682  20.300 1.00 4.94  ? 282  ILE A C   1 
ATOM   2189 O  O   . ILE A 1 305 ? -4.547  -7.535  20.052 1.00 5.49  ? 282  ILE A O   1 
ATOM   2190 C  CB  . ILE A 1 305 ? -2.385  -9.714  18.873 1.00 5.11  ? 282  ILE A CB  1 
ATOM   2191 C  CG1 . ILE A 1 305 ? -0.884  -9.964  18.776 1.00 5.42  ? 282  ILE A CG1 1 
ATOM   2192 C  CG2 . ILE A 1 305 ? -2.873  -8.811  17.734 1.00 4.95  ? 282  ILE A CG2 1 
ATOM   2193 C  CD1 . ILE A 1 305 ? -0.450  -10.820 17.586 1.00 5.85  ? 282  ILE A CD1 1 
ATOM   2194 N  N   . THR A 1 306 ? -5.076  -9.648  20.546 1.00 4.73  ? 283  THR A N   1 
ATOM   2195 C  CA  . THR A 1 306 ? -6.520  -9.425  20.465 1.00 4.99  ? 283  THR A CA  1 
ATOM   2196 C  C   . THR A 1 306 ? -7.216  -9.693  21.779 1.00 5.24  ? 283  THR A C   1 
ATOM   2197 O  O   . THR A 1 306 ? -6.810  -10.575 22.543 1.00 6.25  ? 283  THR A O   1 
ATOM   2198 C  CB  . THR A 1 306 ? -7.131  -10.304 19.368 1.00 5.61  ? 283  THR A CB  1 
ATOM   2199 O  OG1 . THR A 1 306 ? -7.053  -11.703 19.659 1.00 5.95  ? 283  THR A OG1 1 
ATOM   2200 C  CG2 . THR A 1 306 ? -6.547  -10.030 18.000 1.00 5.95  ? 283  THR A CG2 1 
ATOM   2201 N  N   . ALA A 1 307 ? -8.308  -8.980  22.014 1.00 4.89  ? 284  ALA A N   1 
ATOM   2202 C  CA  . ALA A 1 307 ? -9.196  -9.226  23.131 1.00 5.23  ? 284  ALA A CA  1 
ATOM   2203 C  C   . ALA A 1 307 ? -10.613 -8.998  22.629 1.00 5.29  ? 284  ALA A C   1 
ATOM   2204 O  O   . ALA A 1 307 ? -11.263 -7.962  22.900 1.00 5.36  ? 284  ALA A O   1 
ATOM   2205 C  CB  . ALA A 1 307 ? -8.850  -8.431  24.365 1.00 5.73  ? 284  ALA A CB  1 
ATOM   2206 N  N   . ALA A 1 308 ? -11.108 -9.970  21.859 1.00 5.57  ? 285  ALA A N   1 
ATOM   2207 C  CA  . ALA A 1 308 ? -12.361 -9.805  21.118 1.00 5.46  ? 285  ALA A CA  1 
ATOM   2208 C  C   . ALA A 1 308 ? -13.559 -9.895  22.061 1.00 5.31  ? 285  ALA A C   1 
ATOM   2209 O  O   . ALA A 1 308 ? -13.548 -10.602 23.076 1.00 6.11  ? 285  ALA A O   1 
ATOM   2210 C  CB  . ALA A 1 308 ? -12.434 -10.866 20.042 1.00 5.69  ? 285  ALA A CB  1 
ATOM   2211 N  N   . GLN A 1 309 ? -14.622 -9.153  21.708 1.00 5.44  ? 286  GLN A N   1 
ATOM   2212 C  CA  . GLN A 1 309 ? -15.766 -8.981  22.601 1.00 5.32  ? 286  GLN A CA  1 
ATOM   2213 C  C   . GLN A 1 309 ? -17.088 -9.088  21.842 1.00 5.47  ? 286  GLN A C   1 
ATOM   2214 O  O   . GLN A 1 309 ? -18.046 -8.399  22.200 1.00 6.67  ? 286  GLN A O   1 
ATOM   2215 C  CB  . GLN A 1 309 ? -15.649 -7.671  23.377 1.00 5.72  ? 286  GLN A CB  1 
ATOM   2216 C  CG  . GLN A 1 309 ? -16.404 -7.741  24.703 1.00 6.83  ? 286  GLN A CG  1 
ATOM   2217 C  CD  . GLN A 1 309 ? -16.727 -6.414  25.316 1.00 8.72  ? 286  GLN A CD  1 
ATOM   2218 O  OE1 . GLN A 1 309 ? -16.899 -5.417  24.616 1.00 11.28 ? 286  GLN A OE1 1 
ATOM   2219 N  NE2 . GLN A 1 309 ? -16.860 -6.385  26.635 1.00 10.01 ? 286  GLN A NE2 1 
ATOM   2220 N  N   . GLN A 1 310 ? -17.195 -9.933  20.823 1.00 5.48  ? 287  GLN A N   1 
ATOM   2221 C  CA  . GLN A 1 310 ? -18.476 -10.165 20.170 1.00 5.35  ? 287  GLN A CA  1 
ATOM   2222 C  C   . GLN A 1 310 ? -19.360 -11.021 21.079 1.00 5.57  ? 287  GLN A C   1 
ATOM   2223 O  O   . GLN A 1 310 ? -18.923 -12.034 21.623 1.00 6.18  ? 287  GLN A O   1 
ATOM   2224 C  CB  . GLN A 1 310 ? -18.333 -10.889 18.840 1.00 5.69  ? 287  GLN A CB  1 
ATOM   2225 C  CG  . GLN A 1 310 ? -17.457 -10.154 17.850 1.00 5.34  ? 287  GLN A CG  1 
ATOM   2226 C  CD  . GLN A 1 310 ? -15.975 -10.291 18.110 1.00 5.11  ? 287  GLN A CD  1 
ATOM   2227 O  OE1 . GLN A 1 310 ? -15.539 -11.250 18.773 1.00 5.31  ? 287  GLN A OE1 1 
ATOM   2228 N  NE2 . GLN A 1 310 ? -15.199 -9.321  17.613 1.00 5.65  ? 287  GLN A NE2 1 
ATOM   2229 N  N   . SER A 1 311 ? -20.644 -10.668 21.158 1.00 6.31  ? 288  SER A N   1 
ATOM   2230 C  CA  . SER A 1 311 ? -21.702 -11.471 21.752 1.00 6.24  ? 288  SER A CA  1 
ATOM   2231 C  C   . SER A 1 311 ? -22.305 -12.480 20.794 1.00 6.27  ? 288  SER A C   1 
ATOM   2232 O  O   . SER A 1 311 ? -22.960 -13.412 21.230 1.00 7.20  ? 288  SER A O   1 
ATOM   2233 C  CB  . SER A 1 311 ? -22.805 -10.618 22.356 1.00 6.77  ? 288  SER A CB  1 
ATOM   2234 O  OG  . SER A 1 311 ? -23.424 -9.797  21.394 1.00 7.27  ? 288  SER A OG  1 
ATOM   2235 N  N   . SER A 1 312 ? -22.095 -12.272 19.506 1.00 6.28  ? 289  SER A N   1 
ATOM   2236 C  CA  . SER A 1 312 ? -22.707 -13.039 18.440 1.00 6.48  ? 289  SER A CA  1 
ATOM   2237 C  C   . SER A 1 312 ? -22.053 -12.592 17.145 1.00 7.17  ? 289  SER A C   1 
ATOM   2238 O  O   . SER A 1 312 ? -21.476 -11.531 17.096 1.00 7.37  ? 289  SER A O   1 
ATOM   2239 C  CB  . SER A 1 312 ? -24.193 -12.741 18.421 1.00 6.63  ? 289  SER A CB  1 
ATOM   2240 O  OG  . SER A 1 312 ? -24.923 -13.765 17.730 1.00 7.58  ? 289  SER A OG  1 
ATOM   2241 N  N   . GLY A 1 313 ? -22.242 -13.370 16.098 1.00 7.46  ? 290  GLY A N   1 
ATOM   2242 C  CA  . GLY A 1 313 ? -21.833 -12.971 14.774 1.00 7.65  ? 290  GLY A CA  1 
ATOM   2243 C  C   . GLY A 1 313 ? -20.330 -13.094 14.544 1.00 6.99  ? 290  GLY A C   1 
ATOM   2244 O  O   . GLY A 1 313 ? -19.577 -13.675 15.327 1.00 9.21  ? 290  GLY A O   1 
ATOM   2245 N  N   . ARG A 1 314 ? -19.903 -12.501 13.453 1.00 6.54  ? 291  ARG A N   1 
ATOM   2246 C  CA  . ARG A 1 314 ? -18.476 -12.559 13.060 1.00 6.44  ? 291  ARG A CA  1 
ATOM   2247 C  C   . ARG A 1 314 ? -17.600 -11.620 13.888 1.00 6.34  ? 291  ARG A C   1 
ATOM   2248 O  O   . ARG A 1 314 ? -18.038 -10.546 14.279 1.00 6.61  ? 291  ARG A O   1 
ATOM   2249 C  CB  . ARG A 1 314 ? -18.376 -12.143 11.584 1.00 6.71  ? 291  ARG A CB  1 
ATOM   2250 C  CG  . ARG A 1 314 ? -18.898 -13.146 10.561 1.00 7.57  ? 291  ARG A CG  1 
ATOM   2251 C  CD  . ARG A 1 314 ? -17.897 -14.244 10.213 1.00 8.88  ? 291  ARG A CD  1 
ATOM   2252 N  NE  . ARG A 1 314 ? -17.857 -15.349 11.175 1.00 9.03  ? 291  ARG A NE  1 
ATOM   2253 C  CZ  . ARG A 1 314 ? -18.616 -16.429 11.131 1.00 10.11 ? 291  ARG A CZ  1 
ATOM   2254 N  NH1 . ARG A 1 314 ? -19.502 -16.575 10.161 1.00 11.32 ? 291  ARG A NH1 1 
ATOM   2255 N  NH2 . ARG A 1 314 ? -18.492 -17.355 12.062 1.00 9.88  ? 291  ARG A NH2 1 
ATOM   2256 N  N   . GLY A 1 315 ? -16.369 -12.058 14.074 1.00 5.63  ? 292  GLY A N   1 
ATOM   2257 C  CA  . GLY A 1 315 ? -15.418 -11.271 14.856 1.00 5.76  ? 292  GLY A CA  1 
ATOM   2258 C  C   . GLY A 1 315 ? -14.311 -10.697 13.987 1.00 5.37  ? 292  GLY A C   1 
ATOM   2259 O  O   . GLY A 1 315 ? -14.569 -9.964  13.025 1.00 5.40  ? 292  GLY A O   1 
ATOM   2260 N  N   . TYR A 1 316 ? -13.067 -11.005 14.395 1.00 5.39  ? 293  TYR A N   1 
ATOM   2261 C  CA  . TYR A 1 316 ? -11.899 -10.437 13.673 1.00 5.10  ? 293  TYR A CA  1 
ATOM   2262 C  C   . TYR A 1 316 ? -11.303 -11.432 12.691 1.00 5.27  ? 293  TYR A C   1 
ATOM   2263 O  O   . TYR A 1 316 ? -11.142 -12.587 13.030 1.00 5.70  ? 293  TYR A O   1 
ATOM   2264 C  CB  . TYR A 1 316 ? -10.734 -10.055 14.601 1.00 5.58  ? 293  TYR A CB  1 
ATOM   2265 C  CG  . TYR A 1 316 ? -10.941 -9.160  15.817 1.00 5.37  ? 293  TYR A CG  1 
ATOM   2266 C  CD1 . TYR A 1 316 ? -12.131 -8.478  16.053 1.00 5.32  ? 293  TYR A CD1 1 
ATOM   2267 C  CD2 . TYR A 1 316 ? -9.921  -9.024  16.750 1.00 5.72  ? 293  TYR A CD2 1 
ATOM   2268 C  CE1 . TYR A 1 316 ? -12.290 -7.686  17.178 1.00 5.25  ? 293  TYR A CE1 1 
ATOM   2269 C  CE2 . TYR A 1 316 ? -10.063 -8.235  17.876 1.00 5.71  ? 293  TYR A CE2 1 
ATOM   2270 C  CZ  . TYR A 1 316 ? -11.253 -7.570  18.086 1.00 5.32  ? 293  TYR A CZ  1 
ATOM   2271 O  OH  . TYR A 1 316 ? -11.387 -6.815  19.205 1.00 5.91  ? 293  TYR A OH  1 
ATOM   2272 N  N   . LEU A 1 317 ? -10.975 -10.920 11.519 1.00 5.43  ? 294  LEU A N   1 
ATOM   2273 C  CA  . LEU A 1 317 ? -10.241 -11.666 10.501 1.00 5.23  ? 294  LEU A CA  1 
ATOM   2274 C  C   . LEU A 1 317 ? -8.862  -11.048 10.349 1.00 5.73  ? 294  LEU A C   1 
ATOM   2275 O  O   . LEU A 1 317 ? -8.776  -9.921  9.861  1.00 6.17  ? 294  LEU A O   1 
ATOM   2276 C  CB  . LEU A 1 317 ? -10.978 -11.744 9.166  1.00 6.33  ? 294  LEU A CB  1 
ATOM   2277 C  CG  . LEU A 1 317 ? -10.235 -12.435 8.030  1.00 6.80  ? 294  LEU A CG  1 
ATOM   2278 C  CD1 . LEU A 1 317 ? -9.827  -13.839 8.356  1.00 7.69  ? 294  LEU A CD1 1 
ATOM   2279 C  CD2 . LEU A 1 317 ? -11.098 -12.395 6.777  1.00 8.02  ? 294  LEU A CD2 1 
ATOM   2280 N  N   . MET A 1 318 ? -7.832  -11.756 10.795 1.00 5.56  ? 295  MET A N   1 
ATOM   2281 C  CA  . MET A 1 318 ? -6.450  -11.305 10.650 1.00 6.05  ? 295  MET A CA  1 
ATOM   2282 C  C   . MET A 1 318 ? -5.927  -11.991 9.395  1.00 6.51  ? 295  MET A C   1 
ATOM   2283 O  O   . MET A 1 318 ? -5.611  -13.186 9.438  1.00 6.59  ? 295  MET A O   1 
ATOM   2284 C  CB  . MET A 1 318 ? -5.625  -11.672 11.888 1.00 6.44  ? 295  MET A CB  1 
ATOM   2285 C  CG  . MET A 1 318 ? -6.336  -11.468 13.204 1.00 6.82  ? 295  MET A CG  1 
ATOM   2286 S  SD  . MET A 1 318 ? -6.936  -9.805  13.559 1.00 6.71  ? 295  MET A SD  1 
ATOM   2287 C  CE  . MET A 1 318 ? -5.385  -8.957  13.839 1.00 7.79  ? 295  MET A CE  1 
ATOM   2288 N  N   . TYR A 1 319 ? -5.951  -11.282 8.278  1.00 6.21  ? 296  TYR A N   1 
ATOM   2289 C  CA  . TYR A 1 319 ? -5.737  -11.893 6.973  1.00 6.83  ? 296  TYR A CA  1 
ATOM   2290 C  C   . TYR A 1 319 ? -4.333  -11.593 6.478  1.00 6.56  ? 296  TYR A C   1 
ATOM   2291 O  O   . TYR A 1 319 ? -4.012  -10.458 6.122  1.00 6.81  ? 296  TYR A O   1 
ATOM   2292 C  CB  . TYR A 1 319 ? -6.772  -11.292 6.013  1.00 7.29  ? 296  TYR A CB  1 
ATOM   2293 C  CG  . TYR A 1 319 ? -6.917  -12.039 4.694  1.00 8.99  ? 296  TYR A CG  1 
ATOM   2294 C  CD1 . TYR A 1 319 ? -6.053  -11.813 3.646  1.00 11.21 ? 296  TYR A CD1 1 
ATOM   2295 C  CD2 . TYR A 1 319 ? -7.927  -12.957 4.538  1.00 11.04 ? 296  TYR A CD2 1 
ATOM   2296 C  CE1 . TYR A 1 319 ? -6.204  -12.500 2.425  1.00 12.95 ? 296  TYR A CE1 1 
ATOM   2297 C  CE2 . TYR A 1 319 ? -8.091  -13.640 3.345  1.00 14.82 ? 296  TYR A CE2 1 
ATOM   2298 C  CZ  . TYR A 1 319 ? -7.259  -13.360 2.317  1.00 14.52 ? 296  TYR A CZ  1 
ATOM   2299 O  OH  . TYR A 1 319 ? -7.451  -14.035 1.116  1.00 23.00 ? 296  TYR A OH  1 
ATOM   2300 N  N   . GLU A 1 320 ? -3.466  -12.598 6.479  1.00 6.42  ? 297  GLU A N   1 
ATOM   2301 C  CA  . GLU A 1 320 ? -2.114  -12.478 5.941  1.00 7.48  ? 297  GLU A CA  1 
ATOM   2302 C  C   . GLU A 1 320 ? -1.330  -11.375 6.656  1.00 7.36  ? 297  GLU A C   1 
ATOM   2303 O  O   . GLU A 1 320 ? -0.611  -10.579 6.039  1.00 8.07  ? 297  GLU A O   1 
ATOM   2304 C  CB  . GLU A 1 320 ? -2.164  -12.255 4.426  1.00 8.72  ? 297  GLU A CB  1 
ATOM   2305 C  CG  . GLU A 1 320 ? -2.669  -13.520 3.736  1.00 10.69 ? 297  GLU A CG  1 
ATOM   2306 C  CD  . GLU A 1 320 ? -2.802  -13.456 2.240  1.00 13.47 ? 297  GLU A CD  1 
ATOM   2307 O  OE1 . GLU A 1 320 ? -3.106  -14.507 1.684  1.00 12.56 ? 297  GLU A OE1 1 
ATOM   2308 O  OE2 . GLU A 1 320 ? -2.525  -12.407 1.667  1.00 15.20 ? 297  GLU A OE2 1 
ATOM   2309 N  N   . CYS A 1 321 ? -1.437  -11.342 7.979  1.00 6.86  ? 298  CYS A N   1 
ATOM   2310 C  CA  . CYS A 1 321 ? -0.693  -10.389 8.796  1.00 6.06  ? 298  CYS A CA  1 
ATOM   2311 C  C   . CYS A 1 321 ? 0.650   -10.964 9.216  1.00 6.27  ? 298  CYS A C   1 
ATOM   2312 O  O   . CYS A 1 321 ? 0.934   -12.163 9.099  1.00 7.17  ? 298  CYS A O   1 
ATOM   2313 C  CB  . CYS A 1 321 ? -1.502  -10.037 10.042 1.00 5.69  ? 298  CYS A CB  1 
ATOM   2314 S  SG  . CYS A 1 321 ? -3.015  -9.091  9.701  1.00 7.05  ? 298  CYS A SG  1 
ATOM   2315 N  N   . HIS A 1 322 ? 1.507   -10.044 9.650  1.00 5.92  ? 299  HIS A N   1 
ATOM   2316 C  CA  . HIS A 1 322 ? 2.862   -10.338 10.082 1.00 5.89  ? 299  HIS A CA  1 
ATOM   2317 C  C   . HIS A 1 322 ? 2.976   -10.000 11.576 1.00 5.63  ? 299  HIS A C   1 
ATOM   2318 O  O   . HIS A 1 322 ? 2.838   -8.830  11.950 1.00 6.11  ? 299  HIS A O   1 
ATOM   2319 C  CB  . HIS A 1 322 ? 3.848   -9.478  9.266  1.00 6.32  ? 299  HIS A CB  1 
ATOM   2320 C  CG  . HIS A 1 322 ? 5.282   -9.653  9.638  1.00 6.24  ? 299  HIS A CG  1 
ATOM   2321 N  ND1 . HIS A 1 322 ? 6.147   -8.605  9.509  1.00 7.38  ? 299  HIS A ND1 1 
ATOM   2322 C  CD2 . HIS A 1 322 ? 5.957   -10.674 10.193 1.00 6.78  ? 299  HIS A CD2 1 
ATOM   2323 C  CE1 . HIS A 1 322 ? 7.356   -9.005  9.928  1.00 7.43  ? 299  HIS A CE1 1 
ATOM   2324 N  NE2 . HIS A 1 322 ? 7.291   -10.243 10.323 1.00 7.28  ? 299  HIS A NE2 1 
ATOM   2325 N  N   . ILE A 1 323 ? 3.250   -11.019 12.394 1.00 5.86  ? 300  ILE A N   1 
ATOM   2326 C  CA  . ILE A 1 323 ? 3.461   -10.819 13.821 1.00 5.93  ? 300  ILE A CA  1 
ATOM   2327 C  C   . ILE A 1 323 ? 4.936   -10.558 14.051 1.00 5.97  ? 300  ILE A C   1 
ATOM   2328 O  O   . ILE A 1 323 ? 5.805   -11.403 13.748 1.00 6.33  ? 300  ILE A O   1 
ATOM   2329 C  CB  . ILE A 1 323 ? 2.932   -11.982 14.662 1.00 5.77  ? 300  ILE A CB  1 
ATOM   2330 C  CG1 . ILE A 1 323 ? 1.437   -12.077 14.501 1.00 5.83  ? 300  ILE A CG1 1 
ATOM   2331 C  CG2 . ILE A 1 323 ? 3.353   -11.832 16.118 1.00 6.49  ? 300  ILE A CG2 1 
ATOM   2332 C  CD1 . ILE A 1 323 ? 0.795   -13.271 15.165 1.00 6.29  ? 300  ILE A CD1 1 
ATOM   2333 N  N   . THR A 1 324 ? 5.207   -9.369  14.597 1.00 5.59  ? 301  THR A N   1 
ATOM   2334 C  CA  . THR A 1 324 ? 6.564   -8.828  14.679 1.00 5.81  ? 301  THR A CA  1 
ATOM   2335 C  C   . THR A 1 324 ? 6.668   -7.908  15.892 1.00 5.48  ? 301  THR A C   1 
ATOM   2336 O  O   . THR A 1 324 ? 5.838   -7.978  16.793 1.00 5.63  ? 301  THR A O   1 
ATOM   2337 C  CB  . THR A 1 324 ? 6.893   -8.205  13.305 1.00 6.38  ? 301  THR A CB  1 
ATOM   2338 O  OG1 . THR A 1 324 ? 8.276   -7.850  13.224 1.00 6.72  ? 301  THR A OG1 1 
ATOM   2339 C  CG2 . THR A 1 324 ? 6.089   -6.978  12.961 1.00 7.03  ? 301  THR A CG2 1 
ATOM   2340 N  N   . SER A 1 325 ? 7.700   -7.077  15.886 1.00 5.90  ? 302  SER A N   1 
ATOM   2341 C  CA  . SER A 1 325 ? 8.091   -6.278  17.045 1.00 5.84  ? 302  SER A CA  1 
ATOM   2342 C  C   . SER A 1 325 ? 8.460   -4.861  16.657 1.00 6.26  ? 302  SER A C   1 
ATOM   2343 O  O   . SER A 1 325 ? 8.869   -4.615  15.517 1.00 6.89  ? 302  SER A O   1 
ATOM   2344 C  CB  . SER A 1 325 ? 9.289   -6.904  17.752 1.00 6.28  ? 302  SER A CB  1 
ATOM   2345 O  OG  . SER A 1 325 ? 9.087   -8.262  18.113 1.00 6.51  ? 302  SER A OG  1 
ATOM   2346 N  N   . VAL A 1 326 ? 8.439   -3.982  17.645 1.00 6.46  ? 303  VAL A N   1 
ATOM   2347 C  CA  . VAL A 1 326 ? 8.991   -2.630  17.474 1.00 6.16  ? 303  VAL A CA  1 
ATOM   2348 C  C   . VAL A 1 326 ? 10.526  -2.651  17.391 1.00 6.34  ? 303  VAL A C   1 
ATOM   2349 O  O   . VAL A 1 326 ? 11.169  -3.680  17.613 1.00 7.49  ? 303  VAL A O   1 
ATOM   2350 C  CB  . VAL A 1 326 ? 8.511   -1.728  18.626 1.00 6.45  ? 303  VAL A CB  1 
ATOM   2351 C  CG1 . VAL A 1 326 ? 7.001   -1.523  18.585 1.00 6.92  ? 303  VAL A CG1 1 
ATOM   2352 C  CG2 . VAL A 1 326 ? 8.981   -2.221  19.963 1.00 6.37  ? 303  VAL A CG2 1 
ATOM   2353 N  N   A GLU A 1 327 ? 11.066  -1.473  17.070 0.50 7.14  ? 304  GLU A N   1 
ATOM   2354 N  N   B GLU A 1 327 ? 11.061  -1.472  17.065 0.50 6.97  ? 304  GLU A N   1 
ATOM   2355 C  CA  A GLU A 1 327 ? 12.529  -1.309  16.906 0.50 7.69  ? 304  GLU A CA  1 
ATOM   2356 C  CA  B GLU A 1 327 ? 12.523  -1.310  16.906 0.50 7.39  ? 304  GLU A CA  1 
ATOM   2357 C  C   A GLU A 1 327 ? 13.032  -0.168  17.786 0.50 7.30  ? 304  GLU A C   1 
ATOM   2358 C  C   B GLU A 1 327 ? 13.028  -0.169  17.789 0.50 7.19  ? 304  GLU A C   1 
ATOM   2359 O  O   A GLU A 1 327 ? 12.433  0.917   17.797 0.50 7.44  ? 304  GLU A O   1 
ATOM   2360 O  O   B GLU A 1 327 ? 12.433  0.918   17.797 0.50 7.39  ? 304  GLU A O   1 
ATOM   2361 C  CB  A GLU A 1 327 ? 12.748  -0.936  15.442 0.50 9.58  ? 304  GLU A CB  1 
ATOM   2362 C  CB  B GLU A 1 327 ? 12.797  -0.947  15.447 0.50 9.00  ? 304  GLU A CB  1 
ATOM   2363 C  CG  A GLU A 1 327 ? 14.198  -0.699  15.037 0.50 12.04 ? 304  GLU A CG  1 
ATOM   2364 C  CG  B GLU A 1 327 ? 14.289  -0.813  15.162 0.50 11.21 ? 304  GLU A CG  1 
ATOM   2365 C  CD  A GLU A 1 327 ? 14.161  -0.336  13.563 0.50 15.07 ? 304  GLU A CD  1 
ATOM   2366 C  CD  B GLU A 1 327 ? 14.767  -0.967  13.731 0.50 13.95 ? 304  GLU A CD  1 
ATOM   2367 O  OE1 A GLU A 1 327 ? 14.160  -1.271  12.740 0.50 21.61 ? 304  GLU A OE1 1 
ATOM   2368 O  OE1 B GLU A 1 327 ? 16.000  -0.967  13.545 0.50 11.97 ? 304  GLU A OE1 1 
ATOM   2369 O  OE2 A GLU A 1 327 ? 14.057  0.864   13.239 0.50 17.04 ? 304  GLU A OE2 1 
ATOM   2370 O  OE2 B GLU A 1 327 ? 13.936  -1.090  12.811 0.50 19.78 ? 304  GLU A OE2 1 
ATOM   2371 N  N   . ALA A 1 328 ? 14.123  -0.428  18.473 1.00 6.83  ? 305  ALA A N   1 
ATOM   2372 C  CA  . ALA A 1 328 ? 14.783  0.572   19.281 1.00 7.02  ? 305  ALA A CA  1 
ATOM   2373 C  C   . ALA A 1 328 ? 15.302  1.720   18.436 1.00 7.45  ? 305  ALA A C   1 
ATOM   2374 O  O   . ALA A 1 328 ? 15.768  1.509   17.317 1.00 8.42  ? 305  ALA A O   1 
ATOM   2375 C  CB  . ALA A 1 328 ? 15.965  -0.014  20.037 1.00 7.55  ? 305  ALA A CB  1 
ATOM   2376 N  N   . GLY A 1 329 ? 15.207  2.922   18.956 1.00 7.55  ? 306  GLY A N   1 
ATOM   2377 C  CA  . GLY A 1 329 ? 15.710  4.150   18.342 1.00 8.26  ? 306  GLY A CA  1 
ATOM   2378 C  C   . GLY A 1 329 ? 14.731  4.800   17.387 1.00 8.84  ? 306  GLY A C   1 
ATOM   2379 O  O   . GLY A 1 329 ? 14.784  6.000   17.219 1.00 10.72 ? 306  GLY A O   1 
ATOM   2380 N  N   A THR A 1 330 ? 13.842  4.052   16.747 0.50 7.82  ? 307  THR A N   1 
ATOM   2381 N  N   B THR A 1 330 ? 13.890  3.980   16.760 0.50 9.03  ? 307  THR A N   1 
ATOM   2382 C  CA  A THR A 1 330 ? 12.755  4.668   15.996 0.50 7.25  ? 307  THR A CA  1 
ATOM   2383 C  CA  B THR A 1 330 ? 12.827  4.409   15.868 0.50 9.32  ? 307  THR A CA  1 
ATOM   2384 C  C   A THR A 1 330 ? 11.478  4.653   16.831 0.50 7.02  ? 307  THR A C   1 
ATOM   2385 C  C   B THR A 1 330 ? 11.525  4.551   16.666 0.50 8.22  ? 307  THR A C   1 
ATOM   2386 O  O   A THR A 1 330 ? 10.924  5.728   17.129 0.50 7.27  ? 307  THR A O   1 
ATOM   2387 O  O   B THR A 1 330 ? 10.991  5.631   16.802 0.50 7.97  ? 307  THR A O   1 
ATOM   2388 C  CB  A THR A 1 330 ? 12.608  3.954   14.655 0.50 6.72  ? 307  THR A CB  1 
ATOM   2389 C  CB  B THR A 1 330 ? 12.735  3.367   14.751 0.50 10.66 ? 307  THR A CB  1 
ATOM   2390 O  OG1 A THR A 1 330 ? 12.535  2.544   14.918 0.50 6.70  ? 307  THR A OG1 1 
ATOM   2391 O  OG1 B THR A 1 330 ? 13.821  3.395   13.821 0.50 12.49 ? 307  THR A OG1 1 
ATOM   2392 C  CG2 A THR A 1 330 ? 13.792  4.285   13.758 0.50 7.02  ? 307  THR A CG2 1 
ATOM   2393 C  CG2 B THR A 1 330 ? 11.519  3.575   13.881 0.50 11.37 ? 307  THR A CG2 1 
ATOM   2394 N  N   . ASP A 1 331 ? 11.032  3.425   17.182 1.00 7.53  ? 308  ASP A N   1 
ATOM   2395 C  CA  . ASP A 1 331 ? 9.768   3.323   17.890 1.00 6.29  ? 308  ASP A CA  1 
ATOM   2396 C  C   . ASP A 1 331 ? 9.852   3.538   19.393 1.00 6.04  ? 308  ASP A C   1 
ATOM   2397 O  O   . ASP A 1 331 ? 8.893   4.009   19.982 1.00 6.77  ? 308  ASP A O   1 
ATOM   2398 C  CB  . ASP A 1 331 ? 9.185   1.948   17.690 1.00 6.34  ? 308  ASP A CB  1 
ATOM   2399 C  CG  . ASP A 1 331 ? 8.933   1.522   16.250 1.00 6.51  ? 308  ASP A CG  1 
ATOM   2400 O  OD1 . ASP A 1 331 ? 8.334   2.355   15.531 1.00 6.57  ? 308  ASP A OD1 1 
ATOM   2401 O  OD2 . ASP A 1 331 ? 9.302   0.403   15.879 1.00 7.06  ? 308  ASP A OD2 1 
ATOM   2402 N  N   . VAL A 1 332 ? 10.957  3.070   19.997 1.00 6.16  ? 309  VAL A N   1 
ATOM   2403 C  CA  . VAL A 1 332 ? 11.023  2.940   21.447 1.00 6.01  ? 309  VAL A CA  1 
ATOM   2404 C  C   . VAL A 1 332 ? 12.442  3.238   21.918 1.00 5.96  ? 309  VAL A C   1 
ATOM   2405 O  O   . VAL A 1 332 ? 13.402  3.244   21.153 1.00 6.80  ? 309  VAL A O   1 
ATOM   2406 C  CB  . VAL A 1 332 ? 10.596  1.555   21.944 1.00 6.03  ? 309  VAL A CB  1 
ATOM   2407 C  CG1 . VAL A 1 332 ? 9.163   1.199   21.500 1.00 5.92  ? 309  VAL A CG1 1 
ATOM   2408 C  CG2 . VAL A 1 332 ? 11.545  0.453   21.503 1.00 6.46  ? 309  VAL A CG2 1 
ATOM   2409 N  N   . ASP A 1 333 ? 12.577  3.408   23.226 1.00 6.38  ? 310  ASP A N   1 
ATOM   2410 C  CA  A ASP A 1 333 ? 13.851  3.707   23.864 0.70 6.87  ? 310  ASP A CA  1 
ATOM   2411 C  CA  B ASP A 1 333 ? 13.837  3.700   23.893 0.30 6.35  ? 310  ASP A CA  1 
ATOM   2412 C  C   . ASP A 1 333 ? 14.596  2.396   24.135 1.00 6.93  ? 310  ASP A C   1 
ATOM   2413 O  O   . ASP A 1 333 ? 14.110  1.490   24.818 1.00 7.39  ? 310  ASP A O   1 
ATOM   2414 C  CB  A ASP A 1 333 ? 13.644  4.503   25.137 0.70 7.98  ? 310  ASP A CB  1 
ATOM   2415 C  CB  B ASP A 1 333 ? 13.577  4.373   25.230 0.30 6.18  ? 310  ASP A CB  1 
ATOM   2416 C  CG  A ASP A 1 333 ? 14.885  5.180   25.690 0.70 9.57  ? 310  ASP A CG  1 
ATOM   2417 C  CG  B ASP A 1 333 ? 14.787  4.948   25.946 0.30 5.99  ? 310  ASP A CG  1 
ATOM   2418 O  OD1 A ASP A 1 333 ? 15.901  4.450   25.836 0.70 9.55  ? 310  ASP A OD1 1 
ATOM   2419 O  OD1 B ASP A 1 333 ? 15.952  4.729   25.395 0.30 5.41  ? 310  ASP A OD1 1 
ATOM   2420 O  OD2 A ASP A 1 333 ? 14.813  6.391   25.928 0.70 10.49 ? 310  ASP A OD2 1 
ATOM   2421 O  OD2 B ASP A 1 333 ? 14.498  5.657   26.951 0.30 5.81  ? 310  ASP A OD2 1 
ATOM   2422 N  N   . SER A 1 334 ? 15.819  2.313   23.617 1.00 7.57  ? 311  SER A N   1 
ATOM   2423 C  CA  . SER A 1 334 ? 16.682  1.146   23.833 1.00 7.88  ? 311  SER A CA  1 
ATOM   2424 C  C   . SER A 1 334 ? 16.967  0.893   25.312 1.00 7.82  ? 311  SER A C   1 
ATOM   2425 O  O   . SER A 1 334 ? 17.298  -0.249  25.662 1.00 8.40  ? 311  SER A O   1 
ATOM   2426 C  CB  . SER A 1 334 ? 18.005  1.319   23.117 1.00 8.78  ? 311  SER A CB  1 
ATOM   2427 O  OG  . SER A 1 334 ? 18.743  2.416   23.650 1.00 10.03 ? 311  SER A OG  1 
ATOM   2428 N  N   . LYS A 1 335 ? 16.822  1.882   26.184 1.00 7.61  ? 312  LYS A N   1 
ATOM   2429 C  CA  . LYS A 1 335 ? 17.068  1.677   27.599 1.00 8.71  ? 312  LYS A CA  1 
ATOM   2430 C  C   . LYS A 1 335 ? 16.230  0.561   28.176 1.00 8.09  ? 312  LYS A C   1 
ATOM   2431 O  O   . LYS A 1 335 ? 16.626  -0.142  29.107 1.00 9.47  ? 312  LYS A O   1 
ATOM   2432 C  CB  . LYS A 1 335 ? 16.796  2.931   28.400 1.00 10.00 ? 312  LYS A CB  1 
ATOM   2433 C  CG  . LYS A 1 335 ? 17.278  2.883   29.864 1.00 13.31 ? 312  LYS A CG  1 
ATOM   2434 C  CD  . LYS A 1 335 ? 17.270  4.229   30.587 1.00 16.82 ? 312  LYS A CD  1 
ATOM   2435 C  CE  . LYS A 1 335 ? 17.755  4.074   32.013 1.00 20.62 ? 312  LYS A CE  1 
ATOM   2436 N  NZ  . LYS A 1 335 ? 17.767  5.343   32.740 0.50 21.75 ? 312  LYS A NZ  1 
ATOM   2437 N  N   . TYR A 1 336 ? 15.010  0.384   27.626 1.00 7.04  ? 313  TYR A N   1 
ATOM   2438 C  CA  . TYR A 1 336 ? 14.068  -0.607  28.125 1.00 6.80  ? 313  TYR A CA  1 
ATOM   2439 C  C   . TYR A 1 336 ? 13.769  -1.694  27.099 1.00 6.88  ? 313  TYR A C   1 
ATOM   2440 O  O   . TYR A 1 336 ? 12.815  -2.429  27.280 1.00 7.92  ? 313  TYR A O   1 
ATOM   2441 C  CB  . TYR A 1 336 ? 12.764  0.059   28.578 1.00 7.47  ? 313  TYR A CB  1 
ATOM   2442 C  CG  . TYR A 1 336 ? 12.994  1.382   29.288 1.00 7.43  ? 313  TYR A CG  1 
ATOM   2443 C  CD1 . TYR A 1 336 ? 13.655  1.437   30.509 1.00 7.52  ? 313  TYR A CD1 1 
ATOM   2444 C  CD2 . TYR A 1 336 ? 12.508  2.553   28.754 1.00 7.90  ? 313  TYR A CD2 1 
ATOM   2445 C  CE1 . TYR A 1 336 ? 13.836  2.638   31.156 1.00 8.33  ? 313  TYR A CE1 1 
ATOM   2446 C  CE2 . TYR A 1 336 ? 12.707  3.778   29.366 1.00 8.03  ? 313  TYR A CE2 1 
ATOM   2447 C  CZ  . TYR A 1 336 ? 13.370  3.793   30.587 1.00 8.32  ? 313  TYR A CZ  1 
ATOM   2448 O  OH  . TYR A 1 336 ? 13.550  5.029   31.183 1.00 10.99 ? 313  TYR A OH  1 
ATOM   2449 N  N   . TYR A 1 337 ? 14.513  -1.736  25.991 1.00 7.28  ? 314  TYR A N   1 
ATOM   2450 C  CA  . TYR A 1 337 ? 14.225  -2.655  24.846 1.00 6.97  ? 314  TYR A CA  1 
ATOM   2451 C  C   . TYR A 1 337 ? 15.591  -3.028  24.330 1.00 6.81  ? 314  TYR A C   1 
ATOM   2452 O  O   . TYR A 1 337 ? 16.101  -2.389  23.423 1.00 8.25  ? 314  TYR A O   1 
ATOM   2453 C  CB  . TYR A 1 337 ? 13.329  -1.884  23.874 1.00 7.22  ? 314  TYR A CB  1 
ATOM   2454 C  CG  . TYR A 1 337 ? 12.755  -2.790  22.789 1.00 6.74  ? 314  TYR A CG  1 
ATOM   2455 C  CD1 . TYR A 1 337 ? 11.686  -3.630  23.062 1.00 6.28  ? 314  TYR A CD1 1 
ATOM   2456 C  CD2 . TYR A 1 337 ? 13.283  -2.816  21.503 1.00 7.52  ? 314  TYR A CD2 1 
ATOM   2457 C  CE1 . TYR A 1 337 ? 11.139  -4.441  22.085 1.00 6.58  ? 314  TYR A CE1 1 
ATOM   2458 C  CE2 . TYR A 1 337 ? 12.758  -3.638  20.522 1.00 7.80  ? 314  TYR A CE2 1 
ATOM   2459 C  CZ  . TYR A 1 337 ? 11.677  -4.445  20.814 1.00 6.97  ? 314  TYR A CZ  1 
ATOM   2460 O  OH  . TYR A 1 337 ? 11.138  -5.233  19.846 1.00 8.58  ? 314  TYR A OH  1 
ATOM   2461 N  N   . SER A 1 338 ? 16.116  -4.130  24.829 1.00 7.33  ? 315  SER A N   1 
ATOM   2462 C  CA  . SER A 1 338 ? 17.539  -4.422  24.709 1.00 7.80  ? 315  SER A CA  1 
ATOM   2463 C  C   . SER A 1 338 ? 17.854  -5.534  23.726 1.00 8.18  ? 315  SER A C   1 
ATOM   2464 O  O   . SER A 1 338 ? 19.050  -5.843  23.579 1.00 10.51 ? 315  SER A O   1 
ATOM   2465 C  CB  . SER A 1 338 ? 18.078  -4.783  26.097 1.00 8.40  ? 315  SER A CB  1 
ATOM   2466 O  OG  . SER A 1 338 ? 17.889  -3.700  26.989 1.00 10.58 ? 315  SER A OG  1 
ATOM   2467 N  N   . TYR A 1 339 ? 16.835  -6.111  23.095 1.00 7.17  ? 316  TYR A N   1 
ATOM   2468 C  CA  . TYR A 1 339 ? 17.014  -7.324  22.247 1.00 7.17  ? 316  TYR A CA  1 
ATOM   2469 C  C   . TYR A 1 339 ? 16.555  -7.062  20.824 1.00 6.90  ? 316  TYR A C   1 
ATOM   2470 O  O   . TYR A 1 339 ? 16.133  -5.956  20.483 1.00 7.99  ? 316  TYR A O   1 
ATOM   2471 C  CB  . TYR A 1 339 ? 16.265  -8.488  22.926 1.00 7.83  ? 316  TYR A CB  1 
ATOM   2472 C  CG  . TYR A 1 339 ? 16.751  -8.702  24.354 1.00 8.23  ? 316  TYR A CG  1 
ATOM   2473 C  CD1 . TYR A 1 339 ? 16.164  -8.036  25.424 1.00 7.53  ? 316  TYR A CD1 1 
ATOM   2474 C  CD2 . TYR A 1 339 ? 17.832  -9.530  24.620 1.00 9.41  ? 316  TYR A CD2 1 
ATOM   2475 C  CE1 . TYR A 1 339 ? 16.637  -8.194  26.713 1.00 8.65  ? 316  TYR A CE1 1 
ATOM   2476 C  CE2 . TYR A 1 339 ? 18.310  -9.699  25.908 1.00 10.29 ? 316  TYR A CE2 1 
ATOM   2477 C  CZ  . TYR A 1 339 ? 17.713  -9.026  26.957 1.00 9.66  ? 316  TYR A CZ  1 
ATOM   2478 O  OH  . TYR A 1 339 ? 18.178  -9.186  28.231 1.00 11.57 ? 316  TYR A OH  1 
ATOM   2479 N  N   . THR A 1 340 ? 16.606  -8.119  20.013 1.00 6.97  ? 317  THR A N   1 
ATOM   2480 C  CA  . THR A 1 340 ? 16.306  -7.932  18.604 1.00 7.12  ? 317  THR A CA  1 
ATOM   2481 C  C   . THR A 1 340 ? 14.819  -7.990  18.292 1.00 7.76  ? 317  THR A C   1 
ATOM   2482 O  O   . THR A 1 340 ? 14.422  -7.602  17.197 1.00 8.77  ? 317  THR A O   1 
ATOM   2483 C  CB  . THR A 1 340 ? 17.063  -8.939  17.736 1.00 7.39  ? 317  THR A CB  1 
ATOM   2484 O  OG1 . THR A 1 340 ? 16.637  -10.273 17.996 1.00 7.75  ? 317  THR A OG1 1 
ATOM   2485 C  CG2 . THR A 1 340 ? 18.573  -8.824  17.848 1.00 7.90  ? 317  THR A CG2 1 
ATOM   2486 N  N   . THR A 1 341 ? 14.018  -8.500  19.219 1.00 6.89  ? 318  THR A N   1 
ATOM   2487 C  CA  . THR A 1 341 ? 12.566  -8.656  19.088 1.00 6.85  ? 318  THR A CA  1 
ATOM   2488 C  C   . THR A 1 341 ? 12.004  -8.408  20.471 1.00 6.13  ? 318  THR A C   1 
ATOM   2489 O  O   . THR A 1 341 ? 12.712  -8.311  21.477 1.00 6.35  ? 318  THR A O   1 
ATOM   2490 C  CB  . THR A 1 341 ? 12.158  -10.059 18.611 1.00 6.50  ? 318  THR A CB  1 
ATOM   2491 O  OG1 . THR A 1 341 ? 12.361  -11.000 19.687 1.00 6.80  ? 318  THR A OG1 1 
ATOM   2492 C  CG2 . THR A 1 341 ? 12.949  -10.526 17.404 1.00 6.76  ? 318  THR A CG2 1 
ATOM   2493 N  N   . SER A 1 342 ? 10.663  -8.348  20.524 1.00 6.21  ? 319  SER A N   1 
ATOM   2494 C  CA  . SER A 1 342 ? 9.950   -8.506  21.783 1.00 5.75  ? 319  SER A CA  1 
ATOM   2495 C  C   . SER A 1 342 ? 10.144  -9.921  22.317 1.00 5.27  ? 319  SER A C   1 
ATOM   2496 O  O   . SER A 1 342 ? 10.407  -10.859 21.600 1.00 6.03  ? 319  SER A O   1 
ATOM   2497 C  CB  . SER A 1 342 ? 8.472   -8.246  21.526 1.00 5.82  ? 319  SER A CB  1 
ATOM   2498 O  OG  . SER A 1 342 ? 7.626   -8.513  22.649 1.00 6.56  ? 319  SER A OG  1 
ATOM   2499 N  N   . LYS A 1 343 ? 9.918   -10.069 23.609 1.00 5.61  ? 320  LYS A N   1 
ATOM   2500 C  CA  . LYS A 1 343 ? 9.701   -11.382 24.138 1.00 5.94  ? 320  LYS A CA  1 
ATOM   2501 C  C   . LYS A 1 343 ? 8.447   -11.974 23.508 1.00 5.69  ? 320  LYS A C   1 
ATOM   2502 O  O   . LYS A 1 343 ? 7.608   -11.245 22.976 1.00 6.05  ? 320  LYS A O   1 
ATOM   2503 C  CB  . LYS A 1 343 ? 9.610   -11.389 25.658 1.00 6.04  ? 320  LYS A CB  1 
ATOM   2504 C  CG  . LYS A 1 343 ? 8.284   -10.894 26.223 1.00 6.08  ? 320  LYS A CG  1 
ATOM   2505 C  CD  . LYS A 1 343 ? 8.199   -10.918 27.751 1.00 6.50  ? 320  LYS A CD  1 
ATOM   2506 C  CE  . LYS A 1 343 ? 9.215   -10.094 28.484 1.00 6.74  ? 320  LYS A CE  1 
ATOM   2507 N  NZ  . LYS A 1 343 ? 9.151   -8.661  28.103 1.00 6.44  ? 320  LYS A NZ  1 
ATOM   2508 N  N   . PRO A 1 344 ? 8.258   -13.307 23.534 1.00 5.65  ? 321  PRO A N   1 
ATOM   2509 C  CA  . PRO A 1 344 ? 7.073   -13.875 22.933 1.00 5.86  ? 321  PRO A CA  1 
ATOM   2510 C  C   . PRO A 1 344 ? 5.797   -13.367 23.586 1.00 5.82  ? 321  PRO A C   1 
ATOM   2511 O  O   . PRO A 1 344 ? 5.759   -13.052 24.771 1.00 6.21  ? 321  PRO A O   1 
ATOM   2512 C  CB  . PRO A 1 344 ? 7.263   -15.383 23.166 1.00 6.46  ? 321  PRO A CB  1 
ATOM   2513 C  CG  . PRO A 1 344 ? 8.749   -15.566 23.448 1.00 6.89  ? 321  PRO A CG  1 
ATOM   2514 C  CD  . PRO A 1 344 ? 9.127   -14.312 24.165 1.00 6.48  ? 321  PRO A CD  1 
ATOM   2515 N  N   . GLY A 1 345 ? 4.738   -13.344 22.775 1.00 5.33  ? 322  GLY A N   1 
ATOM   2516 C  CA  . GLY A 1 345 ? 3.425   -12.965 23.247 1.00 5.39  ? 322  GLY A CA  1 
ATOM   2517 C  C   . GLY A 1 345 ? 2.383   -13.969 22.784 1.00 5.64  ? 322  GLY A C   1 
ATOM   2518 O  O   . GLY A 1 345 ? 2.690   -15.124 22.518 1.00 5.92  ? 322  GLY A O   1 
ATOM   2519 N  N   . TYR A 1 346 ? 1.126   -13.510 22.740 1.00 5.62  ? 323  TYR A N   1 
ATOM   2520 C  CA  . TYR A 1 346 ? -0.011  -14.381 22.465 1.00 5.47  ? 323  TYR A CA  1 
ATOM   2521 C  C   . TYR A 1 346 ? -0.861  -13.769 21.373 1.00 4.96  ? 323  TYR A C   1 
ATOM   2522 O  O   . TYR A 1 346 ? -0.961  -12.546 21.219 1.00 5.58  ? 323  TYR A O   1 
ATOM   2523 C  CB  . TYR A 1 346 ? -0.863  -14.570 23.711 1.00 5.65  ? 323  TYR A CB  1 
ATOM   2524 C  CG  . TYR A 1 346 ? -0.127  -15.326 24.802 1.00 5.92  ? 323  TYR A CG  1 
ATOM   2525 C  CD1 . TYR A 1 346 ? 0.763   -14.678 25.639 1.00 6.80  ? 323  TYR A CD1 1 
ATOM   2526 C  CD2 . TYR A 1 346 ? -0.304  -16.685 25.009 1.00 5.99  ? 323  TYR A CD2 1 
ATOM   2527 C  CE1 . TYR A 1 346 ? 1.460   -15.364 26.613 1.00 6.57  ? 323  TYR A CE1 1 
ATOM   2528 C  CE2 . TYR A 1 346 ? 0.370   -17.368 26.003 1.00 6.69  ? 323  TYR A CE2 1 
ATOM   2529 C  CZ  . TYR A 1 346 ? 1.247   -16.696 26.805 1.00 6.53  ? 323  TYR A CZ  1 
ATOM   2530 O  OH  . TYR A 1 346 ? 1.926   -17.393 27.774 1.00 7.89  ? 323  TYR A OH  1 
ATOM   2531 N  N   . PHE A 1 347 ? -1.589  -14.635 20.667 1.00 5.23  ? 324  PHE A N   1 
ATOM   2532 C  CA  . PHE A 1 347 ? -2.612  -14.188 19.676 1.00 4.85  ? 324  PHE A CA  1 
ATOM   2533 C  C   . PHE A 1 347 ? -3.732  -13.367 20.363 1.00 5.10  ? 324  PHE A C   1 
ATOM   2534 O  O   . PHE A 1 347 ? -4.288  -12.496 19.722 1.00 5.62  ? 324  PHE A O   1 
ATOM   2535 C  CB  . PHE A 1 347 ? -3.297  -15.407 19.019 1.00 5.25  ? 324  PHE A CB  1 
ATOM   2536 C  CG  . PHE A 1 347 ? -2.460  -16.225 18.038 1.00 5.56  ? 324  PHE A CG  1 
ATOM   2537 C  CD1 . PHE A 1 347 ? -1.799  -15.614 16.978 1.00 6.10  ? 324  PHE A CD1 1 
ATOM   2538 C  CD2 . PHE A 1 347 ? -2.360  -17.607 18.168 1.00 5.97  ? 324  PHE A CD2 1 
ATOM   2539 C  CE1 . PHE A 1 347 ? -1.062  -16.362 16.072 1.00 6.63  ? 324  PHE A CE1 1 
ATOM   2540 C  CE2 . PHE A 1 347 ? -1.616  -18.350 17.263 1.00 6.49  ? 324  PHE A CE2 1 
ATOM   2541 C  CZ  . PHE A 1 347 ? -0.975  -17.726 16.215 1.00 6.47  ? 324  PHE A CZ  1 
ATOM   2542 N  N   . GLY A 1 348 ? -4.045  -13.710 21.607 1.00 5.33  ? 325  GLY A N   1 
ATOM   2543 C  CA  . GLY A 1 348 ? -5.081  -12.977 22.276 1.00 5.57  ? 325  GLY A CA  1 
ATOM   2544 C  C   . GLY A 1 348 ? -5.586  -13.666 23.519 1.00 5.30  ? 325  GLY A C   1 
ATOM   2545 O  O   . GLY A 1 348 ? -5.150  -14.768 23.883 1.00 5.54  ? 325  GLY A O   1 
ATOM   2546 N  N   . ARG A 1 349 ? -6.549  -12.938 24.089 1.00 5.50  ? 326  ARG A N   1 
ATOM   2547 C  CA  . ARG A 1 349 ? -7.273  -13.378 25.297 1.00 6.32  ? 326  ARG A CA  1 
ATOM   2548 C  C   . ARG A 1 349 ? -8.734  -12.980 25.068 1.00 6.07  ? 326  ARG A C   1 
ATOM   2549 O  O   . ARG A 1 349 ? -9.028  -11.799 25.074 1.00 6.37  ? 326  ARG A O   1 
ATOM   2550 C  CB  . ARG A 1 349 ? -6.809  -12.611 26.546 1.00 9.12  ? 326  ARG A CB  1 
ATOM   2551 C  CG  . ARG A 1 349 ? -5.305  -12.487 26.742 1.00 9.64  ? 326  ARG A CG  1 
ATOM   2552 C  CD  . ARG A 1 349 ? -5.047  -12.067 28.177 1.00 10.48 ? 326  ARG A CD  1 
ATOM   2553 N  NE  . ARG A 1 349 ? -5.421  -10.671 28.430 1.00 10.48 ? 326  ARG A NE  1 
ATOM   2554 C  CZ  . ARG A 1 349 ? -5.364  -10.106 29.626 1.00 9.64  ? 326  ARG A CZ  1 
ATOM   2555 N  NH1 . ARG A 1 349 ? -5.094  -10.839 30.689 1.00 12.23 ? 326  ARG A NH1 1 
ATOM   2556 N  NH2 . ARG A 1 349 ? -5.590  -8.817  29.767 1.00 9.42  ? 326  ARG A NH2 1 
ATOM   2557 N  N   . PRO A 1 350 ? -9.664  -13.918 24.818 1.00 6.02  ? 327  PRO A N   1 
ATOM   2558 C  CA  . PRO A 1 350 ? -11.038 -13.496 24.539 1.00 6.50  ? 327  PRO A CA  1 
ATOM   2559 C  C   . PRO A 1 350 ? -11.600 -12.662 25.679 1.00 6.25  ? 327  PRO A C   1 
ATOM   2560 O  O   . PRO A 1 350 ? -11.420 -13.058 26.837 1.00 6.75  ? 327  PRO A O   1 
ATOM   2561 C  CB  . PRO A 1 350 ? -11.808 -14.803 24.409 1.00 7.71  ? 327  PRO A CB  1 
ATOM   2562 C  CG  . PRO A 1 350 ? -10.779 -15.794 24.034 1.00 7.95  ? 327  PRO A CG  1 
ATOM   2563 C  CD  . PRO A 1 350 ? -9.479  -15.361 24.635 1.00 6.93  ? 327  PRO A CD  1 
ATOM   2564 N  N   . TRP A 1 351 ? -12.287 -11.564 25.380 1.00 5.91  ? 328  TRP A N   1 
ATOM   2565 C  CA  . TRP A 1 351 ? -12.932 -10.780 26.436 1.00 6.05  ? 328  TRP A CA  1 
ATOM   2566 C  C   . TRP A 1 351 ? -14.357 -11.266 26.677 1.00 6.57  ? 328  TRP A C   1 
ATOM   2567 O  O   . TRP A 1 351 ? -14.738 -11.477 27.817 1.00 7.91  ? 328  TRP A O   1 
ATOM   2568 C  CB  . TRP A 1 351 ? -12.867 -9.292  26.037 1.00 6.44  ? 328  TRP A CB  1 
ATOM   2569 C  CG  . TRP A 1 351 ? -13.237 -8.363  27.154 1.00 6.58  ? 328  TRP A CG  1 
ATOM   2570 C  CD1 . TRP A 1 351 ? -13.467 -8.698  28.443 1.00 7.18  ? 328  TRP A CD1 1 
ATOM   2571 C  CD2 . TRP A 1 351 ? -13.396 -6.937  27.064 1.00 7.43  ? 328  TRP A CD2 1 
ATOM   2572 N  NE1 . TRP A 1 351 ? -13.759 -7.565  29.179 1.00 7.97  ? 328  TRP A NE1 1 
ATOM   2573 C  CE2 . TRP A 1 351 ? -13.772 -6.491  28.345 1.00 8.12  ? 328  TRP A CE2 1 
ATOM   2574 C  CE3 . TRP A 1 351 ? -13.315 -6.023  26.021 1.00 7.22  ? 328  TRP A CE3 1 
ATOM   2575 C  CZ2 . TRP A 1 351 ? -14.053 -5.139  28.597 1.00 8.43  ? 328  TRP A CZ2 1 
ATOM   2576 C  CZ3 . TRP A 1 351 ? -13.656 -4.704  26.256 1.00 7.59  ? 328  TRP A CZ3 1 
ATOM   2577 C  CH2 . TRP A 1 351 ? -14.014 -4.294  27.528 1.00 8.68  ? 328  TRP A CH2 1 
ATOM   2578 N  N   . GLN A 1 352 ? -15.139 -11.493 25.628 1.00 6.71  ? 329  GLN A N   1 
ATOM   2579 C  CA  . GLN A 1 352 ? -16.485 -12.073 25.770 1.00 6.80  ? 329  GLN A CA  1 
ATOM   2580 C  C   . GLN A 1 352 ? -16.334 -13.588 25.711 1.00 7.31  ? 329  GLN A C   1 
ATOM   2581 O  O   . GLN A 1 352 ? -15.925 -14.167 24.699 1.00 7.61  ? 329  GLN A O   1 
ATOM   2582 C  CB  . GLN A 1 352 ? -17.455 -11.524 24.734 1.00 7.22  ? 329  GLN A CB  1 
ATOM   2583 C  CG  . GLN A 1 352 ? -18.863 -12.031 24.966 1.00 7.94  ? 329  GLN A CG  1 
ATOM   2584 C  CD  . GLN A 1 352 ? -19.520 -11.382 26.139 1.00 9.36  ? 329  GLN A CD  1 
ATOM   2585 O  OE1 . GLN A 1 352 ? -19.141 -10.274 26.540 1.00 10.21 ? 329  GLN A OE1 1 
ATOM   2586 N  NE2 . GLN A 1 352 ? -20.529 -12.035 26.679 1.00 11.61 ? 329  GLN A NE2 1 
ATOM   2587 N  N   . ALA A 1 353 ? -16.722 -14.285 26.771 1.00 7.61  ? 330  ALA A N   1 
ATOM   2588 C  CA  . ALA A 1 353 ? -16.669 -15.718 26.770 1.00 8.12  ? 330  ALA A CA  1 
ATOM   2589 C  C   . ALA A 1 353 ? -17.538 -16.337 25.694 1.00 7.67  ? 330  ALA A C   1 
ATOM   2590 O  O   . ALA A 1 353 ? -18.627 -15.830 25.430 1.00 7.25  ? 330  ALA A O   1 
ATOM   2591 C  CB  . ALA A 1 353 ? -17.102 -16.243 28.104 1.00 9.99  ? 330  ALA A CB  1 
ATOM   2592 N  N   . ASN A 1 354 ? -17.076 -17.480 25.172 1.00 7.72  ? 331  ASN A N   1 
ATOM   2593 C  CA  . ASN A 1 354 ? -17.803 -18.392 24.293 1.00 8.58  ? 331  ASN A CA  1 
ATOM   2594 C  C   . ASN A 1 354 ? -18.034 -17.859 22.884 1.00 8.06  ? 331  ASN A C   1 
ATOM   2595 O  O   . ASN A 1 354 ? -17.811 -18.595 21.937 1.00 9.21  ? 331  ASN A O   1 
ATOM   2596 C  CB  . ASN A 1 354 ? -19.138 -18.832 24.892 1.00 9.76  ? 331  ASN A CB  1 
ATOM   2597 C  CG  . ASN A 1 354 ? -18.998 -19.352 26.304 1.00 13.45 ? 331  ASN A CG  1 
ATOM   2598 O  OD1 . ASN A 1 354 ? -18.023 -20.048 26.600 1.00 16.00 ? 331  ASN A OD1 1 
ATOM   2599 N  ND2 . ASN A 1 354 ? -19.868 -18.939 27.208 1.00 14.18 ? 331  ASN A ND2 1 
ATOM   2600 N  N   . THR A 1 355 ? -18.482 -16.616 22.735 1.00 6.85  ? 332  THR A N   1 
ATOM   2601 C  CA  . THR A 1 355 ? -19.009 -16.104 21.483 1.00 6.80  ? 332  THR A CA  1 
ATOM   2602 C  C   . THR A 1 355 ? -18.035 -15.199 20.742 1.00 6.57  ? 332  THR A C   1 
ATOM   2603 O  O   . THR A 1 355 ? -18.254 -14.922 19.566 1.00 7.95  ? 332  THR A O   1 
ATOM   2604 C  CB  . THR A 1 355 ? -20.317 -15.366 21.737 1.00 6.52  ? 332  THR A CB  1 
ATOM   2605 O  OG1 . THR A 1 355 ? -20.120 -14.356 22.702 1.00 6.42  ? 332  THR A OG1 1 
ATOM   2606 C  CG2 . THR A 1 355 ? -21.399 -16.314 22.206 1.00 7.33  ? 332  THR A CG2 1 
ATOM   2607 N  N   . SER A 1 356 ? -16.997 -14.692 21.408 1.00 6.28  ? 333  SER A N   1 
ATOM   2608 C  CA  . SER A 1 356 ? -16.040 -13.874 20.676 1.00 6.29  ? 333  SER A CA  1 
ATOM   2609 C  C   . SER A 1 356 ? -15.310 -14.733 19.642 1.00 5.88  ? 333  SER A C   1 
ATOM   2610 O  O   . SER A 1 356 ? -15.223 -15.962 19.752 1.00 6.31  ? 333  SER A O   1 
ATOM   2611 C  CB  . SER A 1 356 ? -15.129 -13.101 21.563 1.00 7.33  ? 333  SER A CB  1 
ATOM   2612 O  OG  . SER A 1 356 ? -14.383 -13.907 22.406 1.00 8.21  ? 333  SER A OG  1 
ATOM   2613 N  N   . GLU A 1 357 ? -14.804 -14.077 18.599 1.00 5.35  ? 334  GLU A N   1 
ATOM   2614 C  CA  . GLU A 1 357 ? -14.221 -14.778 17.465 1.00 5.75  ? 334  GLU A CA  1 
ATOM   2615 C  C   . GLU A 1 357 ? -13.044 -13.990 16.921 1.00 5.49  ? 334  GLU A C   1 
ATOM   2616 O  O   . GLU A 1 357 ? -13.158 -12.822 16.633 1.00 5.61  ? 334  GLU A O   1 
ATOM   2617 C  CB  . GLU A 1 357 ? -15.280 -14.999 16.376 1.00 5.96  ? 334  GLU A CB  1 
ATOM   2618 C  CG  . GLU A 1 357 ? -14.726 -15.632 15.103 1.00 6.42  ? 334  GLU A CG  1 
ATOM   2619 C  CD  . GLU A 1 357 ? -15.830 -15.765 14.065 1.00 7.35  ? 334  GLU A CD  1 
ATOM   2620 O  OE1 . GLU A 1 357 ? -16.459 -16.855 13.994 1.00 8.99  ? 334  GLU A OE1 1 
ATOM   2621 O  OE2 . GLU A 1 357 ? -16.049 -14.824 13.288 1.00 7.48  ? 334  GLU A OE2 1 
ATOM   2622 N  N   . VAL A 1 358 ? -11.922 -14.695 16.719 1.00 5.35  ? 335  VAL A N   1 
ATOM   2623 C  CA  . VAL A 1 358 ? -10.763 -14.173 16.022 1.00 5.74  ? 335  VAL A CA  1 
ATOM   2624 C  C   . VAL A 1 358 ? -10.223 -15.269 15.129 1.00 5.63  ? 335  VAL A C   1 
ATOM   2625 O  O   . VAL A 1 358 ? -10.101 -16.402 15.594 1.00 5.99  ? 335  VAL A O   1 
ATOM   2626 C  CB  . VAL A 1 358 ? -9.643  -13.696 16.972 1.00 5.45  ? 335  VAL A CB  1 
ATOM   2627 C  CG1 . VAL A 1 358 ? -8.438  -13.188 16.219 1.00 5.83  ? 335  VAL A CG1 1 
ATOM   2628 C  CG2 . VAL A 1 358 ? -10.150 -12.654 17.945 1.00 5.45  ? 335  VAL A CG2 1 
ATOM   2629 N  N   . VAL A 1 359 ? -9.873  -14.921 13.901 1.00 5.59  ? 336  VAL A N   1 
ATOM   2630 C  CA  . VAL A 1 359 ? -9.313  -15.859 12.948 1.00 6.10  ? 336  VAL A CA  1 
ATOM   2631 C  C   . VAL A 1 359 ? -7.962  -15.334 12.499 1.00 5.90  ? 336  VAL A C   1 
ATOM   2632 O  O   . VAL A 1 359 ? -7.906  -14.331 11.805 1.00 6.38  ? 336  VAL A O   1 
ATOM   2633 C  CB  . VAL A 1 359 ? -10.230 -16.070 11.743 1.00 6.72  ? 336  VAL A CB  1 
ATOM   2634 C  CG1 . VAL A 1 359 ? -9.658  -17.086 10.760 1.00 7.43  ? 336  VAL A CG1 1 
ATOM   2635 C  CG2 . VAL A 1 359 ? -11.645 -16.455 12.167 1.00 7.64  ? 336  VAL A CG2 1 
ATOM   2636 N  N   . PHE A 1 360 ? -6.902  -16.038 12.846 1.00 5.64  ? 337  PHE A N   1 
ATOM   2637 C  CA  . PHE A 1 360 ? -5.583  -15.812 12.293 1.00 6.19  ? 337  PHE A CA  1 
ATOM   2638 C  C   . PHE A 1 360 ? -5.466  -16.688 11.056 1.00 6.31  ? 337  PHE A C   1 
ATOM   2639 O  O   . PHE A 1 360 ? -5.382  -17.884 11.214 1.00 7.54  ? 337  PHE A O   1 
ATOM   2640 C  CB  . PHE A 1 360 ? -4.482  -16.038 13.335 1.00 6.08  ? 337  PHE A CB  1 
ATOM   2641 C  CG  . PHE A 1 360 ? -4.236  -14.837 14.227 1.00 5.63  ? 337  PHE A CG  1 
ATOM   2642 C  CD1 . PHE A 1 360 ? -3.332  -13.855 13.850 1.00 5.82  ? 337  PHE A CD1 1 
ATOM   2643 C  CD2 . PHE A 1 360 ? -4.918  -14.685 15.411 1.00 5.85  ? 337  PHE A CD2 1 
ATOM   2644 C  CE1 . PHE A 1 360 ? -3.122  -12.735 14.648 1.00 6.12  ? 337  PHE A CE1 1 
ATOM   2645 C  CE2 . PHE A 1 360 ? -4.706  -13.581 16.206 1.00 5.91  ? 337  PHE A CE2 1 
ATOM   2646 C  CZ  . PHE A 1 360 ? -3.817  -12.609 15.832 1.00 5.89  ? 337  PHE A CZ  1 
ATOM   2647 N  N   . TYR A 1 361 ? -5.335  -16.055 9.895  1.00 6.47  ? 338  TYR A N   1 
ATOM   2648 C  CA  . TYR A 1 361 ? -5.319  -16.717 8.590  1.00 6.03  ? 338  TYR A CA  1 
ATOM   2649 C  C   . TYR A 1 361 ? -4.046  -16.356 7.863  1.00 6.25  ? 338  TYR A C   1 
ATOM   2650 O  O   . TYR A 1 361 ? -3.814  -15.187 7.580  1.00 6.55  ? 338  TYR A O   1 
ATOM   2651 C  CB  . TYR A 1 361 ? -6.548  -16.264 7.797  1.00 6.78  ? 338  TYR A CB  1 
ATOM   2652 C  CG  . TYR A 1 361 ? -6.579  -16.703 6.333  1.00 7.34  ? 338  TYR A CG  1 
ATOM   2653 C  CD1 . TYR A 1 361 ? -7.118  -17.936 5.953  1.00 7.63  ? 338  TYR A CD1 1 
ATOM   2654 C  CD2 . TYR A 1 361 ? -6.072  -15.879 5.343  1.00 7.62  ? 338  TYR A CD2 1 
ATOM   2655 C  CE1 . TYR A 1 361 ? -7.184  -18.294 4.618  1.00 8.93  ? 338  TYR A CE1 1 
ATOM   2656 C  CE2 . TYR A 1 361 ? -6.097  -16.264 4.014  1.00 9.09  ? 338  TYR A CE2 1 
ATOM   2657 C  CZ  . TYR A 1 361 ? -6.655  -17.460 3.658  1.00 9.14  ? 338  TYR A CZ  1 
ATOM   2658 O  OH  . TYR A 1 361 ? -6.711  -17.762 2.294  1.00 10.65 ? 338  TYR A OH  1 
ATOM   2659 N  N   . ASN A 1 362 ? -3.262  -17.366 7.488  1.00 6.16  ? 339  ASN A N   1 
ATOM   2660 C  CA  . ASN A 1 362 ? -2.056  -17.136 6.702  1.00 6.86  ? 339  ASN A CA  1 
ATOM   2661 C  C   . ASN A 1 362 ? -1.092  -16.149 7.349  1.00 6.38  ? 339  ASN A C   1 
ATOM   2662 O  O   . ASN A 1 362 ? -0.541  -15.250 6.687  1.00 6.81  ? 339  ASN A O   1 
ATOM   2663 C  CB  . ASN A 1 362 ? -2.381  -16.749 5.262  1.00 7.22  ? 339  ASN A CB  1 
ATOM   2664 C  CG  . ASN A 1 362 ? -2.737  -17.922 4.391  1.00 9.01  ? 339  ASN A CG  1 
ATOM   2665 O  OD1 . ASN A 1 362 ? -2.857  -19.062 4.847  1.00 10.24 ? 339  ASN A OD1 1 
ATOM   2666 N  ND2 . ASN A 1 362 ? -2.984  -17.606 3.127  1.00 9.79  ? 339  ASN A ND2 1 
ATOM   2667 N  N   . THR A 1 363 ? -0.914  -16.321 8.655  1.00 6.07  ? 340  THR A N   1 
ATOM   2668 C  CA  . THR A 1 363 ? -0.059  -15.404 9.414  1.00 6.34  ? 340  THR A CA  1 
ATOM   2669 C  C   . THR A 1 363 ? 1.409   -15.779 9.251  1.00 6.83  ? 340  THR A C   1 
ATOM   2670 O  O   . THR A 1 363 ? 1.692   -16.964 9.351  1.00 8.28  ? 340  THR A O   1 
ATOM   2671 C  CB  . THR A 1 363 ? -0.437  -15.498 10.906 1.00 6.42  ? 340  THR A CB  1 
ATOM   2672 O  OG1 . THR A 1 363 ? -1.848  -15.445 11.073 1.00 6.62  ? 340  THR A OG1 1 
ATOM   2673 C  CG2 . THR A 1 363 ? 0.192   -14.405 11.748 1.00 6.76  ? 340  THR A CG2 1 
ATOM   2674 N  N   . THR A 1 364 ? 2.297   -14.794 9.151  1.00 6.47  ? 341  THR A N   1 
ATOM   2675 C  CA  . THR A 1 364 ? 3.742   -15.057 9.218  1.00 6.73  ? 341  THR A CA  1 
ATOM   2676 C  C   . THR A 1 364 ? 4.197   -14.588 10.587 1.00 6.43  ? 341  THR A C   1 
ATOM   2677 O  O   . THR A 1 364 ? 3.973   -13.417 10.927 1.00 6.97  ? 341  THR A O   1 
ATOM   2678 C  CB  . THR A 1 364 ? 4.484   -14.362 8.092  1.00 8.44  ? 341  THR A CB  1 
ATOM   2679 O  OG1 . THR A 1 364 ? 3.996   -14.926 6.857  1.00 10.80 ? 341  THR A OG1 1 
ATOM   2680 C  CG2 . THR A 1 364 ? 5.981   -14.590 8.182  1.00 10.79 ? 341  THR A CG2 1 
ATOM   2681 N  N   . ILE A 1 365 ? 4.813   -15.462 11.364 1.00 6.33  ? 342  ILE A N   1 
ATOM   2682 C  CA  . ILE A 1 365 ? 5.221   -15.131 12.727 1.00 6.45  ? 342  ILE A CA  1 
ATOM   2683 C  C   . ILE A 1 365 ? 6.736   -15.089 12.800 1.00 6.55  ? 342  ILE A C   1 
ATOM   2684 O  O   . ILE A 1 365 ? 7.389   -16.108 12.504 1.00 7.35  ? 342  ILE A O   1 
ATOM   2685 C  CB  . ILE A 1 365 ? 4.623   -16.144 13.731 1.00 6.53  ? 342  ILE A CB  1 
ATOM   2686 C  CG1 . ILE A 1 365 ? 3.117   -16.265 13.552 1.00 6.46  ? 342  ILE A CG1 1 
ATOM   2687 C  CG2 . ILE A 1 365 ? 4.957   -15.762 15.163 1.00 6.80  ? 342  ILE A CG2 1 
ATOM   2688 C  CD1 . ILE A 1 365 ? 2.458   -17.206 14.539 1.00 7.27  ? 342  ILE A CD1 1 
ATOM   2689 N  N   . ASP A 1 366 ? 7.298   -13.980 13.241 1.00 6.38  ? 343  ASP A N   1 
ATOM   2690 C  CA  . ASP A 1 366 ? 8.748   -13.885 13.440 1.00 6.47  ? 343  ASP A CA  1 
ATOM   2691 C  C   . ASP A 1 366 ? 9.246   -14.973 14.385 1.00 7.08  ? 343  ASP A C   1 
ATOM   2692 O  O   . ASP A 1 366 ? 8.571   -15.478 15.300 1.00 6.77  ? 343  ASP A O   1 
ATOM   2693 C  CB  . ASP A 1 366 ? 9.104   -12.531 13.994 1.00 6.77  ? 343  ASP A CB  1 
ATOM   2694 C  CG  . ASP A 1 366 ? 9.165   -11.432 12.976 1.00 7.46  ? 343  ASP A CG  1 
ATOM   2695 O  OD1 . ASP A 1 366 ? 8.977   -11.715 11.771 1.00 7.61  ? 343  ASP A OD1 1 
ATOM   2696 O  OD2 . ASP A 1 366 ? 9.350   -10.281 13.380 1.00 7.55  ? 343  ASP A OD2 1 
ATOM   2697 N  N   . GLU A 1 367 ? 10.547  -15.275 14.204 1.00 6.95  ? 344  GLU A N   1 
ATOM   2698 C  CA  . GLU A 1 367 ? 11.333  -15.930 15.219 1.00 7.35  ? 344  GLU A CA  1 
ATOM   2699 C  C   . GLU A 1 367 ? 11.685  -14.933 16.320 1.00 6.73  ? 344  GLU A C   1 
ATOM   2700 O  O   . GLU A 1 367 ? 12.047  -13.804 16.030 1.00 8.02  ? 344  GLU A O   1 
ATOM   2701 C  CB  . GLU A 1 367 ? 12.613  -16.452 14.542 1.00 8.32  ? 344  GLU A CB  1 
ATOM   2702 C  CG  . GLU A 1 367 ? 13.552  -17.164 15.515 1.00 9.72  ? 344  GLU A CG  1 
ATOM   2703 C  CD  . GLU A 1 367 ? 14.644  -17.970 14.879 1.00 12.64 ? 344  GLU A CD  1 
ATOM   2704 O  OE1 . GLU A 1 367 ? 14.593  -18.202 13.688 1.00 13.37 ? 344  GLU A OE1 1 
ATOM   2705 O  OE2 . GLU A 1 367 ? 15.555  -18.408 15.638 1.00 16.52 ? 344  GLU A OE2 1 
ATOM   2706 N  N   . CYS A 1 368 ? 11.596  -15.353 17.577 1.00 6.29  ? 345  CYS A N   1 
ATOM   2707 C  CA  . CYS A 1 368 ? 11.982  -14.539 18.696 1.00 6.67  ? 345  CYS A CA  1 
ATOM   2708 C  C   . CYS A 1 368 ? 13.500  -14.495 18.832 1.00 6.62  ? 345  CYS A C   1 
ATOM   2709 O  O   . CYS A 1 368 ? 14.205  -15.492 18.573 1.00 7.67  ? 345  CYS A O   1 
ATOM   2710 C  CB  . CYS A 1 368 ? 11.349  -15.097 19.953 1.00 7.35  ? 345  CYS A CB  1 
ATOM   2711 S  SG  . CYS A 1 368 ? 11.591  -14.165 21.473 1.00 7.79  ? 345  CYS A SG  1 
ATOM   2712 N  N   . ASP A 1 369 ? 13.990  -13.351 19.282 1.00 6.28  ? 346  ASP A N   1 
ATOM   2713 C  CA  . ASP A 1 369 ? 15.394  -13.188 19.683 1.00 6.15  ? 346  ASP A CA  1 
ATOM   2714 C  C   . ASP A 1 369 ? 15.885  -14.430 20.405 1.00 6.78  ? 346  ASP A C   1 
ATOM   2715 O  O   . ASP A 1 369 ? 15.231  -14.887 21.350 1.00 7.15  ? 346  ASP A O   1 
ATOM   2716 C  CB  . ASP A 1 369 ? 15.443  -11.996 20.613 1.00 6.45  ? 346  ASP A CB  1 
ATOM   2717 C  CG  . ASP A 1 369 ? 16.842  -11.697 21.163 1.00 6.79  ? 346  ASP A CG  1 
ATOM   2718 O  OD1 . ASP A 1 369 ? 17.219  -12.328 22.165 1.00 7.15  ? 346  ASP A OD1 1 
ATOM   2719 O  OD2 . ASP A 1 369 ? 17.528  -10.807 20.584 1.00 7.11  ? 346  ASP A OD2 1 
ATOM   2720 N  N   . SER A 1 370 ? 17.051  -14.978 20.031 1.00 6.89  ? 347  SER A N   1 
ATOM   2721 C  CA  . SER A 1 370 ? 17.493  -16.238 20.633 1.00 7.42  ? 347  SER A CA  1 
ATOM   2722 C  C   . SER A 1 370 ? 17.650  -16.178 22.155 1.00 7.30  ? 347  SER A C   1 
ATOM   2723 O  O   . SER A 1 370 ? 17.368  -17.169 22.836 1.00 8.09  ? 347  SER A O   1 
ATOM   2724 C  CB  . SER A 1 370 ? 18.800  -16.651 20.013 1.00 7.95  ? 347  SER A CB  1 
ATOM   2725 O  OG  . SER A 1 370 ? 18.593  -16.869 18.626 1.00 10.63 ? 347  SER A OG  1 
ATOM   2726 N  N   . THR A 1 371 ? 18.127  -15.084 22.688 1.00 6.49  ? 348  THR A N   1 
ATOM   2727 C  CA  . THR A 1 371 ? 18.259  -14.961 24.142 1.00 6.54  ? 348  THR A CA  1 
ATOM   2728 C  C   . THR A 1 371 ? 16.879  -15.032 24.799 1.00 7.03  ? 348  THR A C   1 
ATOM   2729 O  O   . THR A 1 371 ? 16.646  -15.747 25.778 1.00 7.90  ? 348  THR A O   1 
ATOM   2730 C  CB  . THR A 1 371 ? 18.964  -13.648 24.510 1.00 7.01  ? 348  THR A CB  1 
ATOM   2731 O  OG1 . THR A 1 371 ? 20.306  -13.697 23.989 1.00 7.31  ? 348  THR A OG1 1 
ATOM   2732 C  CG2 . THR A 1 371 ? 19.088  -13.470 26.005 1.00 7.81  ? 348  THR A CG2 1 
ATOM   2733 N  N   . LEU A 1 372 ? 15.926  -14.222 24.292 1.00 7.41  ? 349  LEU A N   1 
ATOM   2734 C  CA  . LEU A 1 372 ? 14.592  -14.190 24.891 1.00 6.54  ? 349  LEU A CA  1 
ATOM   2735 C  C   . LEU A 1 372 ? 13.872  -15.502 24.645 1.00 6.62  ? 349  LEU A C   1 
ATOM   2736 O  O   . LEU A 1 372 ? 13.064  -15.934 25.503 1.00 7.22  ? 349  LEU A O   1 
ATOM   2737 C  CB  . LEU A 1 372 ? 13.793  -13.025 24.325 1.00 6.78  ? 349  LEU A CB  1 
ATOM   2738 C  CG  . LEU A 1 372 ? 14.384  -11.636 24.558 1.00 7.11  ? 349  LEU A CG  1 
ATOM   2739 C  CD1 . LEU A 1 372 ? 13.406  -10.597 24.015 1.00 7.09  ? 349  LEU A CD1 1 
ATOM   2740 C  CD2 . LEU A 1 372 ? 14.709  -11.393 26.009 1.00 7.39  ? 349  LEU A CD2 1 
ATOM   2741 N  N   . ALA A 1 373 ? 14.129  -16.171 23.515 1.00 6.73  ? 350  ALA A N   1 
ATOM   2742 C  CA  . ALA A 1 373 ? 13.505  -17.462 23.227 1.00 7.96  ? 350  ALA A CA  1 
ATOM   2743 C  C   . ALA A 1 373 ? 13.829  -18.472 24.308 1.00 8.57  ? 350  ALA A C   1 
ATOM   2744 O  O   . ALA A 1 373 ? 12.964  -19.207 24.765 1.00 9.07  ? 350  ALA A O   1 
ATOM   2745 C  CB  . ALA A 1 373 ? 13.953  -17.989 21.889 1.00 7.28  ? 350  ALA A CB  1 
ATOM   2746 N  N   . SER A 1 374 ? 15.101  -18.464 24.742 1.00 8.42  ? 351  SER A N   1 
ATOM   2747 C  CA  A SER A 1 374 ? 15.566  -19.350 25.795 0.50 9.67  ? 351  SER A CA  1 
ATOM   2748 C  CA  B SER A 1 374 ? 15.511  -19.390 25.777 0.50 9.26  ? 351  SER A CA  1 
ATOM   2749 C  C   . SER A 1 374 ? 14.928  -18.977 27.122 1.00 9.23  ? 351  SER A C   1 
ATOM   2750 O  O   . SER A 1 374 ? 14.392  -19.831 27.840 1.00 11.43 ? 351  SER A O   1 
ATOM   2751 C  CB  A SER A 1 374 ? 17.085  -19.299 25.867 0.50 10.86 ? 351  SER A CB  1 
ATOM   2752 C  CB  B SER A 1 374 ? 17.011  -19.516 25.799 0.50 9.97  ? 351  SER A CB  1 
ATOM   2753 O  OG  A SER A 1 374 ? 17.662  -19.899 24.716 0.50 13.68 ? 351  SER A OG  1 
ATOM   2754 O  OG  B SER A 1 374 ? 17.405  -20.321 26.900 0.50 11.32 ? 351  SER A OG  1 
ATOM   2755 N  N   . THR A 1 375 ? 14.957  -17.704 27.474 1.00 8.03  ? 352  THR A N   1 
ATOM   2756 C  CA  . THR A 1 375 ? 14.418  -17.255 28.759 1.00 8.66  ? 352  THR A CA  1 
ATOM   2757 C  C   . THR A 1 375 ? 12.932  -17.575 28.891 1.00 8.75  ? 352  THR A C   1 
ATOM   2758 O  O   . THR A 1 375 ? 12.441  -18.070 29.910 1.00 9.99  ? 352  THR A O   1 
ATOM   2759 C  CB  . THR A 1 375 ? 14.601  -15.758 28.933 1.00 7.85  ? 352  THR A CB  1 
ATOM   2760 O  OG1 . THR A 1 375 ? 16.009  -15.500 28.896 1.00 10.06 ? 352  THR A OG1 1 
ATOM   2761 C  CG2 . THR A 1 375 ? 13.987  -15.209 30.185 1.00 8.79  ? 352  THR A CG2 1 
ATOM   2762 N  N   . TYR A 1 376 ? 12.165  -17.307 27.827 1.00 7.71  ? 353  TYR A N   1 
ATOM   2763 C  CA  . TYR A 1 376 ? 10.675  -17.396 27.912 1.00 7.70  ? 353  TYR A CA  1 
ATOM   2764 C  C   . TYR A 1 376 ? 10.135  -18.693 27.310 1.00 8.66  ? 353  TYR A C   1 
ATOM   2765 O  O   . TYR A 1 376 ? 8.919   -18.850 27.301 1.00 10.30 ? 353  TYR A O   1 
ATOM   2766 C  CB  . TYR A 1 376 ? 10.125  -16.115 27.255 1.00 7.57  ? 353  TYR A CB  1 
ATOM   2767 C  CG  . TYR A 1 376 ? 10.495  -14.894 28.079 1.00 8.28  ? 353  TYR A CG  1 
ATOM   2768 C  CD1 . TYR A 1 376 ? 9.903   -14.668 29.314 1.00 8.26  ? 353  TYR A CD1 1 
ATOM   2769 C  CD2 . TYR A 1 376 ? 11.486  -14.021 27.660 1.00 8.14  ? 353  TYR A CD2 1 
ATOM   2770 C  CE1 . TYR A 1 376 ? 10.268  -13.590 30.098 1.00 8.39  ? 353  TYR A CE1 1 
ATOM   2771 C  CE2 . TYR A 1 376 ? 11.859  -12.938 28.434 1.00 8.15  ? 353  TYR A CE2 1 
ATOM   2772 C  CZ  . TYR A 1 376 ? 11.253  -12.728 29.656 1.00 7.59  ? 353  TYR A CZ  1 
ATOM   2773 O  OH  . TYR A 1 376 ? 11.629  -11.677 30.425 1.00 9.31  ? 353  TYR A OH  1 
ATOM   2774 N  N   . GLY A 1 377 ? 10.991  -19.580 26.827 1.00 8.94  ? 354  GLY A N   1 
ATOM   2775 C  CA  . GLY A 1 377 ? 10.577  -20.888 26.397 1.00 9.42  ? 354  GLY A CA  1 
ATOM   2776 C  C   . GLY A 1 377 ? 9.837   -20.920 25.062 1.00 9.97  ? 354  GLY A C   1 
ATOM   2777 O  O   . GLY A 1 377 ? 8.933   -21.751 24.847 1.00 10.95 ? 354  GLY A O   1 
ATOM   2778 N  N   . SER A 1 378 ? 10.246  -20.107 24.078 1.00 9.18  ? 355  SER A N   1 
ATOM   2779 C  CA  . SER A 1 378 ? 9.584   -20.077 22.786 1.00 8.44  ? 355  SER A CA  1 
ATOM   2780 C  C   . SER A 1 378 ? 10.489  -19.501 21.693 1.00 7.58  ? 355  SER A C   1 
ATOM   2781 O  O   . SER A 1 378 ? 10.792  -18.318 21.758 1.00 8.17  ? 355  SER A O   1 
ATOM   2782 C  CB  . SER A 1 378 ? 8.299   -19.250 22.877 1.00 8.26  ? 355  SER A CB  1 
ATOM   2783 O  OG  . SER A 1 378 ? 7.556   -19.338 21.677 1.00 8.27  ? 355  SER A OG  1 
ATOM   2784 N  N   A SER A 1 379 ? 10.830  -20.327 20.703 0.50 8.50  ? 356  SER A N   1 
ATOM   2785 N  N   B SER A 1 379 ? 10.806  -20.317 20.685 0.50 7.67  ? 356  SER A N   1 
ATOM   2786 C  CA  A SER A 1 379 ? 11.508  -19.813 19.523 0.50 9.09  ? 356  SER A CA  1 
ATOM   2787 C  CA  B SER A 1 379 ? 11.495  -19.817 19.501 0.50 7.64  ? 356  SER A CA  1 
ATOM   2788 C  C   A SER A 1 379 ? 10.586  -18.919 18.697 0.50 7.62  ? 356  SER A C   1 
ATOM   2789 C  C   B SER A 1 379 ? 10.585  -18.950 18.626 0.50 6.99  ? 356  SER A C   1 
ATOM   2790 O  O   A SER A 1 379 ? 11.082  -18.034 18.020 0.50 8.29  ? 356  SER A O   1 
ATOM   2791 O  O   B SER A 1 379 ? 11.060  -18.139 17.834 0.50 7.50  ? 356  SER A O   1 
ATOM   2792 C  CB  A SER A 1 379 ? 12.123  -20.880 18.667 0.50 11.15 ? 356  SER A CB  1 
ATOM   2793 C  CB  B SER A 1 379 ? 12.156  -20.924 18.719 0.50 8.36  ? 356  SER A CB  1 
ATOM   2794 O  OG  A SER A 1 379 ? 11.111  -21.620 18.013 0.50 13.95 ? 356  SER A OG  1 
ATOM   2795 O  OG  B SER A 1 379 ? 13.158  -21.551 19.519 0.50 8.42  ? 356  SER A OG  1 
ATOM   2796 N  N   . SER A 1 380 ? 9.273   -19.217 18.663 1.00 6.94  ? 357  SER A N   1 
ATOM   2797 C  CA  . SER A 1 380 ? 8.307   -18.377 17.990 1.00 6.72  ? 357  SER A CA  1 
ATOM   2798 C  C   . SER A 1 380 ? 8.034   -17.128 18.830 1.00 6.50  ? 357  SER A C   1 
ATOM   2799 O  O   . SER A 1 380 ? 7.955   -17.154 20.063 1.00 6.65  ? 357  SER A O   1 
ATOM   2800 C  CB  . SER A 1 380 ? 7.023   -19.113 17.817 1.00 6.87  ? 357  SER A CB  1 
ATOM   2801 O  OG  . SER A 1 380 ? 6.039   -18.273 17.212 1.00 7.33  ? 357  SER A OG  1 
ATOM   2802 N  N   . LEU A 1 381 ? 7.766   -16.028 18.133 1.00 6.17  ? 358  LEU A N   1 
ATOM   2803 C  CA  . LEU A 1 381 ? 7.278   -14.817 18.787 1.00 5.91  ? 358  LEU A CA  1 
ATOM   2804 C  C   . LEU A 1 381 ? 5.877   -14.968 19.374 1.00 5.66  ? 358  LEU A C   1 
ATOM   2805 O  O   . LEU A 1 381 ? 5.454   -14.121 20.158 1.00 6.47  ? 358  LEU A O   1 
ATOM   2806 C  CB  . LEU A 1 381 ? 7.337   -13.671 17.780 1.00 5.93  ? 358  LEU A CB  1 
ATOM   2807 C  CG  . LEU A 1 381 ? 7.273   -12.251 18.367 1.00 7.32  ? 358  LEU A CG  1 
ATOM   2808 C  CD1 . LEU A 1 381 ? 8.332   -11.930 19.356 1.00 9.34  ? 358  LEU A CD1 1 
ATOM   2809 C  CD2 . LEU A 1 381 ? 7.288   -11.196 17.291 1.00 6.71  ? 358  LEU A CD2 1 
ATOM   2810 N  N   . ILE A 1 382 ? 5.160   -16.043 19.052 1.00 5.72  ? 359  ILE A N   1 
ATOM   2811 C  CA  . ILE A 1 382 ? 3.929   -16.423 19.743 1.00 5.71  ? 359  ILE A CA  1 
ATOM   2812 C  C   . ILE A 1 382 ? 4.199   -17.657 20.571 1.00 5.88  ? 359  ILE A C   1 
ATOM   2813 O  O   . ILE A 1 382 ? 4.640   -18.700 20.081 1.00 6.77  ? 359  ILE A O   1 
ATOM   2814 C  CB  . ILE A 1 382 ? 2.756   -16.621 18.765 1.00 5.75  ? 359  ILE A CB  1 
ATOM   2815 C  CG1 . ILE A 1 382 ? 2.404   -15.304 18.080 1.00 6.23  ? 359  ILE A CG1 1 
ATOM   2816 C  CG2 . ILE A 1 382 ? 1.534   -17.262 19.421 1.00 5.92  ? 359  ILE A CG2 1 
ATOM   2817 C  CD1 . ILE A 1 382 ? 1.764   -14.238 18.948 1.00 6.36  ? 359  ILE A CD1 1 
ATOM   2818 N  N   . GLN A 1 383 ? 3.922   -17.549 21.875 1.00 5.57  ? 360  GLN A N   1 
ATOM   2819 C  CA  . GLN A 1 383 ? 4.020   -18.656 22.805 1.00 5.94  ? 360  GLN A CA  1 
ATOM   2820 C  C   . GLN A 1 383 ? 3.277   -19.873 22.280 1.00 6.13  ? 360  GLN A C   1 
ATOM   2821 O  O   . GLN A 1 383 ? 2.186   -19.758 21.706 1.00 5.96  ? 360  GLN A O   1 
ATOM   2822 C  CB  . GLN A 1 383 ? 3.408   -18.263 24.135 1.00 6.26  ? 360  GLN A CB  1 
ATOM   2823 C  CG  . GLN A 1 383 ? 4.327   -17.446 25.045 1.00 6.83  ? 360  GLN A CG  1 
ATOM   2824 C  CD  . GLN A 1 383 ? 5.385   -18.317 25.675 1.00 7.76  ? 360  GLN A CD  1 
ATOM   2825 O  OE1 . GLN A 1 383 ? 5.262   -19.542 25.740 1.00 9.21  ? 360  GLN A OE1 1 
ATOM   2826 N  NE2 . GLN A 1 383 ? 6.470   -17.694 26.107 1.00 8.09  ? 360  GLN A NE2 1 
ATOM   2827 N  N   . PRO A 1 384 ? 3.788   -21.108 22.524 1.00 6.74  ? 361  PRO A N   1 
ATOM   2828 C  CA  . PRO A 1 384 ? 3.112   -22.313 22.025 1.00 6.82  ? 361  PRO A CA  1 
ATOM   2829 C  C   . PRO A 1 384 ? 1.637   -22.414 22.371 1.00 6.79  ? 361  PRO A C   1 
ATOM   2830 O  O   . PRO A 1 384 ? 0.860   -22.824 21.517 1.00 6.75  ? 361  PRO A O   1 
ATOM   2831 C  CB  . PRO A 1 384 ? 3.943   -23.427 22.693 1.00 7.04  ? 361  PRO A CB  1 
ATOM   2832 C  CG  . PRO A 1 384 ? 5.345   -22.888 22.692 1.00 7.47  ? 361  PRO A CG  1 
ATOM   2833 C  CD  . PRO A 1 384 ? 5.148   -21.418 23.037 1.00 7.03  ? 361  PRO A CD  1 
ATOM   2834 N  N   . ALA A 1 385 ? 1.211   -21.970 23.568 1.00 6.83  ? 362  ALA A N   1 
ATOM   2835 C  CA  . ALA A 1 385 ? -0.200  -22.117 23.927 1.00 6.53  ? 362  ALA A CA  1 
ATOM   2836 C  C   . ALA A 1 385 ? -1.076  -21.226 23.060 1.00 6.32  ? 362  ALA A C   1 
ATOM   2837 O  O   . ALA A 1 385 ? -2.287  -21.478 22.932 1.00 6.30  ? 362  ALA A O   1 
ATOM   2838 C  CB  . ALA A 1 385 ? -0.446  -21.831 25.373 1.00 6.81  ? 362  ALA A CB  1 
ATOM   2839 N  N   . GLY A 1 386 ? -0.537  -20.134 22.484 1.00 6.37  ? 363  GLY A N   1 
ATOM   2840 C  CA  . GLY A 1 386 ? -1.259  -19.277 21.537 1.00 6.02  ? 363  GLY A CA  1 
ATOM   2841 C  C   . GLY A 1 386 ? -2.210  -18.253 22.156 1.00 6.28  ? 363  GLY A C   1 
ATOM   2842 O  O   . GLY A 1 386 ? -2.176  -17.103 21.771 1.00 6.47  ? 363  GLY A O   1 
ATOM   2843 N  N   . TRP A 1 387 ? -3.090  -18.691 23.042 1.00 5.99  ? 364  TRP A N   1 
ATOM   2844 C  CA  . TRP A 1 387 ? -4.194  -17.913 23.560 1.00 6.52  ? 364  TRP A CA  1 
ATOM   2845 C  C   . TRP A 1 387 ? -4.291  -18.114 25.052 1.00 6.61  ? 364  TRP A C   1 
ATOM   2846 O  O   . TRP A 1 387 ? -3.897  -19.187 25.552 1.00 7.74  ? 364  TRP A O   1 
ATOM   2847 C  CB  . TRP A 1 387 ? -5.510  -18.298 22.914 1.00 6.16  ? 364  TRP A CB  1 
ATOM   2848 C  CG  . TRP A 1 387 ? -5.503  -18.377 21.413 1.00 5.45  ? 364  TRP A CG  1 
ATOM   2849 C  CD1 . TRP A 1 387 ? -5.109  -19.429 20.642 1.00 5.91  ? 364  TRP A CD1 1 
ATOM   2850 C  CD2 . TRP A 1 387 ? -5.946  -17.372 20.478 1.00 5.40  ? 364  TRP A CD2 1 
ATOM   2851 N  NE1 . TRP A 1 387 ? -5.255  -19.151 19.316 1.00 5.80  ? 364  TRP A NE1 1 
ATOM   2852 C  CE2 . TRP A 1 387 ? -5.798  -17.901 19.171 1.00 5.38  ? 364  TRP A CE2 1 
ATOM   2853 C  CE3 . TRP A 1 387 ? -6.476  -16.094 20.601 1.00 5.29  ? 364  TRP A CE3 1 
ATOM   2854 C  CZ2 . TRP A 1 387 ? -6.164  -17.212 18.037 1.00 5.86  ? 364  TRP A CZ2 1 
ATOM   2855 C  CZ3 . TRP A 1 387 ? -6.835  -15.400 19.460 1.00 6.10  ? 364  TRP A CZ3 1 
ATOM   2856 C  CH2 . TRP A 1 387 ? -6.725  -15.979 18.201 1.00 6.16  ? 364  TRP A CH2 1 
ATOM   2857 N  N   . LEU A 1 388 ? -4.848  -17.130 25.755 1.00 6.76  ? 365  LEU A N   1 
ATOM   2858 C  CA  . LEU A 1 388 ? -5.080  -17.217 27.193 1.00 6.92  ? 365  LEU A CA  1 
ATOM   2859 C  C   . LEU A 1 388 ? -6.555  -17.053 27.518 1.00 7.06  ? 365  LEU A C   1 
ATOM   2860 O  O   . LEU A 1 388 ? -7.252  -16.262 26.898 1.00 7.67  ? 365  LEU A O   1 
ATOM   2861 C  CB  . LEU A 1 388 ? -4.277  -16.192 28.000 1.00 7.29  ? 365  LEU A CB  1 
ATOM   2862 C  CG  . LEU A 1 388 ? -2.759  -16.339 27.884 1.00 7.63  ? 365  LEU A CG  1 
ATOM   2863 C  CD1 . LEU A 1 388 ? -2.114  -15.086 28.401 1.00 10.08 ? 365  LEU A CD1 1 
ATOM   2864 C  CD2 . LEU A 1 388 ? -2.262  -17.582 28.608 1.00 9.80  ? 365  LEU A CD2 1 
ATOM   2865 N  N   . ASN A 1 389 ? -7.003  -17.736 28.575 1.00 7.14  ? 366  ASN A N   1 
ATOM   2866 C  CA  . ASN A 1 389 ? -8.360  -17.636 29.088 1.00 7.10  ? 366  ASN A CA  1 
ATOM   2867 C  C   . ASN A 1 389 ? -8.529  -16.651 30.229 1.00 7.57  ? 366  ASN A C   1 
ATOM   2868 O  O   . ASN A 1 389 ? -9.573  -16.684 30.876 1.00 7.90  ? 366  ASN A O   1 
ATOM   2869 C  CB  . ASN A 1 389 ? -8.863  -19.025 29.448 1.00 7.03  ? 366  ASN A CB  1 
ATOM   2870 C  CG  . ASN A 1 389 ? -8.163  -19.550 30.668 1.00 8.26  ? 366  ASN A CG  1 
ATOM   2871 O  OD1 . ASN A 1 389 ? -7.264  -18.932 31.225 1.00 8.46  ? 366  ASN A OD1 1 
ATOM   2872 N  ND2 . ASN A 1 389 ? -8.542  -20.758 31.046 1.00 9.04  ? 366  ASN A ND2 1 
ATOM   2873 N  N   . SER A 1 390 ? -7.561  -15.771 30.434 1.00 7.23  ? 367  SER A N   1 
ATOM   2874 C  CA  . SER A 1 390 ? -7.368  -15.012 31.656 1.00 9.21  ? 367  SER A CA  1 
ATOM   2875 C  C   . SER A 1 390 ? -8.158  -13.734 31.672 1.00 10.75 ? 367  SER A C   1 
ATOM   2876 O  O   . SER A 1 390 ? -8.128  -13.068 32.707 1.00 13.13 ? 367  SER A O   1 
ATOM   2877 C  CB  . SER A 1 390 ? -5.886  -14.790 31.879 1.00 11.65 ? 367  SER A CB  1 
ATOM   2878 O  OG  . SER A 1 390 ? -5.294  -14.057 30.821 1.00 12.74 ? 367  SER A OG  1 
ATOM   2879 N  N   A LEU A 1 391 ? -8.851  -13.361 30.585 0.50 11.30 ? 368  LEU A N   1 
ATOM   2880 N  N   B LEU A 1 391 ? -8.833  -13.382 30.582 0.50 9.31  ? 368  LEU A N   1 
ATOM   2881 C  CA  A LEU A 1 391 ? -9.776  -12.238 30.592 0.50 13.75 ? 368  LEU A CA  1 
ATOM   2882 C  CA  B LEU A 1 391 ? -9.560  -12.141 30.530 0.50 10.17 ? 368  LEU A CA  1 
ATOM   2883 C  C   A LEU A 1 391 ? -11.127 -12.806 30.824 0.50 15.24 ? 368  LEU A C   1 
ATOM   2884 C  C   B LEU A 1 391 ? -11.015 -12.550 30.720 0.50 11.19 ? 368  LEU A C   1 
ATOM   2885 O  O   A LEU A 1 391 ? -11.581 -13.085 31.923 0.50 19.88 ? 368  LEU A O   1 
ATOM   2886 O  O   B LEU A 1 391 ? -11.443 -12.588 31.866 0.50 16.66 ? 368  LEU A O   1 
ATOM   2887 C  CB  A LEU A 1 391 ? -9.920  -11.487 29.274 0.50 14.54 ? 368  LEU A CB  1 
ATOM   2888 C  CB  B LEU A 1 391 ? -9.126  -11.334 29.290 0.50 7.93  ? 368  LEU A CB  1 
ATOM   2889 C  CG  A LEU A 1 391 ? -9.054  -10.262 29.122 0.50 13.96 ? 368  LEU A CG  1 
ATOM   2890 C  CG  B LEU A 1 391 ? -9.875  -10.032 29.086 0.50 7.21  ? 368  LEU A CG  1 
ATOM   2891 C  CD1 A LEU A 1 391 ? -9.486  -9.586  27.848 0.50 12.51 ? 368  LEU A CD1 1 
ATOM   2892 C  CD1 B LEU A 1 391 ? -9.331  -9.090  30.161 0.50 7.58  ? 368  LEU A CD1 1 
ATOM   2893 C  CD2 A LEU A 1 391 ? -9.225  -9.373  30.341 0.50 14.29 ? 368  LEU A CD2 1 
ATOM   2894 C  CD2 B LEU A 1 391 ? -9.587  -9.569  27.710 0.50 6.69  ? 368  LEU A CD2 1 
ATOM   2895 N  N   . GLY A 1 392 ? -11.773 -13.033 29.706 1.00 13.91 ? 369  GLY A N   1 
ATOM   2896 C  CA  . GLY A 1 392 ? -13.131 -13.469 29.836 1.00 12.29 ? 369  GLY A CA  1 
ATOM   2897 C  C   . GLY A 1 392 ? -13.348 -14.993 29.860 1.00 15.48 ? 369  GLY A C   1 
ATOM   2898 O  O   . GLY A 1 392 ? -14.399 -15.522 30.247 1.00 17.45 ? 369  GLY A O   1 
ATOM   2899 N  N   . GLY A 1 393 ? -12.340 -15.787 29.467 1.00 12.93 ? 370  GLY A N   1 
ATOM   2900 C  CA  . GLY A 1 393 ? -12.596 -17.211 29.373 1.00 11.98 ? 370  GLY A CA  1 
ATOM   2901 C  C   . GLY A 1 393 ? -12.167 -17.766 28.011 1.00 8.51  ? 370  GLY A C   1 
ATOM   2902 O  O   . GLY A 1 393 ? -11.368 -17.167 27.372 1.00 11.21 ? 370  GLY A O   1 
ATOM   2903 N  N   . GLU A 1 394 ? -12.704 -18.917 27.597 1.00 8.03  ? 371  GLU A N   1 
ATOM   2904 C  CA  . GLU A 1 394 ? -12.483 -19.511 26.269 1.00 7.34  ? 371  GLU A CA  1 
ATOM   2905 C  C   . GLU A 1 394 ? -13.460 -18.904 25.271 1.00 7.13  ? 371  GLU A C   1 
ATOM   2906 O  O   . GLU A 1 394 ? -14.538 -18.462 25.669 1.00 8.47  ? 371  GLU A O   1 
ATOM   2907 C  CB  . GLU A 1 394 ? -12.711 -21.024 26.333 1.00 7.44  ? 371  GLU A CB  1 
ATOM   2908 C  CG  . GLU A 1 394 ? -11.853 -21.736 27.385 1.00 7.80  ? 371  GLU A CG  1 
ATOM   2909 C  CD  . GLU A 1 394 ? -12.092 -23.228 27.381 1.00 7.27  ? 371  GLU A CD  1 
ATOM   2910 O  OE1 . GLU A 1 394 ? -11.589 -23.861 28.371 1.00 8.01  ? 371  GLU A OE1 1 
ATOM   2911 O  OE2 . GLU A 1 394 ? -12.693 -23.815 26.478 1.00 8.65  ? 371  GLU A OE2 1 
ATOM   2912 N  N   . ALA A 1 395 ? -13.128 -18.914 23.979 1.00 6.06  ? 372  ALA A N   1 
ATOM   2913 C  CA  . ALA A 1 395 ? -14.045 -18.514 22.916 1.00 6.05  ? 372  ALA A CA  1 
ATOM   2914 C  C   . ALA A 1 395 ? -13.497 -19.013 21.588 1.00 6.50  ? 372  ALA A C   1 
ATOM   2915 O  O   . ALA A 1 395 ? -12.537 -19.794 21.554 1.00 6.80  ? 372  ALA A O   1 
ATOM   2916 C  CB  . ALA A 1 395 ? -14.296 -17.002 22.911 1.00 6.18  ? 372  ALA A CB  1 
ATOM   2917 N  N   A GLN A 1 396 ? -14.063 -18.541 20.478 0.70 6.17  ? 373  GLN A N   1 
ATOM   2918 N  N   B GLN A 1 396 ? -14.100 -18.559 20.480 0.30 6.08  ? 373  GLN A N   1 
ATOM   2919 C  CA  A GLN A 1 396 ? -13.866 -19.167 19.179 0.70 6.76  ? 373  GLN A CA  1 
ATOM   2920 C  CA  B GLN A 1 396 ? -13.892 -19.137 19.159 0.30 6.13  ? 373  GLN A CA  1 
ATOM   2921 C  C   A GLN A 1 396 ? -12.664 -18.542 18.478 0.70 5.98  ? 373  GLN A C   1 
ATOM   2922 C  C   B GLN A 1 396 ? -12.666 -18.526 18.484 0.30 5.92  ? 373  GLN A C   1 
ATOM   2923 O  O   A GLN A 1 396 ? -12.793 -17.673 17.634 0.70 6.13  ? 373  GLN A O   1 
ATOM   2924 O  O   B GLN A 1 396 ? -12.779 -17.686 17.598 0.30 5.99  ? 373  GLN A O   1 
ATOM   2925 C  CB  A GLN A 1 396 ? -15.174 -19.073 18.416 0.70 7.68  ? 373  GLN A CB  1 
ATOM   2926 C  CB  B GLN A 1 396 ? -15.100 -18.876 18.268 0.30 6.17  ? 373  GLN A CB  1 
ATOM   2927 C  CG  A GLN A 1 396 ? -16.303 -19.849 19.118 0.70 9.01  ? 373  GLN A CG  1 
ATOM   2928 C  CG  B GLN A 1 396 ? -16.421 -19.389 18.834 0.30 6.56  ? 373  GLN A CG  1 
ATOM   2929 C  CD  A GLN A 1 396 ? -17.666 -19.577 18.530 0.70 12.74 ? 373  GLN A CD  1 
ATOM   2930 C  CD  B GLN A 1 396 ? -17.592 -18.894 18.029 0.30 6.88  ? 373  GLN A CD  1 
ATOM   2931 O  OE1 A GLN A 1 396 ? -17.874 -19.592 17.323 0.70 14.49 ? 373  GLN A OE1 1 
ATOM   2932 O  OE1 B GLN A 1 396 ? -17.927 -17.699 18.039 0.30 8.77  ? 373  GLN A OE1 1 
ATOM   2933 N  NE2 A GLN A 1 396 ? -18.625 -19.282 19.397 0.70 15.57 ? 373  GLN A NE2 1 
ATOM   2934 N  NE2 B GLN A 1 396 ? -18.163 -19.861 17.328 0.30 7.46  ? 373  GLN A NE2 1 
ATOM   2935 N  N   . MET A 1 397 ? -11.495 -18.972 18.927 1.00 6.04  ? 374  MET A N   1 
ATOM   2936 C  CA  . MET A 1 397 ? -10.209 -18.457 18.494 1.00 6.11  ? 374  MET A CA  1 
ATOM   2937 C  C   . MET A 1 397 ? -9.572  -19.458 17.537 1.00 6.16  ? 374  MET A C   1 
ATOM   2938 O  O   . MET A 1 397 ? -9.347  -20.607 17.938 1.00 6.39  ? 374  MET A O   1 
ATOM   2939 C  CB  . MET A 1 397 ? -9.285  -18.233 19.693 1.00 6.31  ? 374  MET A CB  1 
ATOM   2940 C  CG  . MET A 1 397 ? -9.856  -17.262 20.749 1.00 6.16  ? 374  MET A CG  1 
ATOM   2941 S  SD  . MET A 1 397 ? -10.135 -15.573 20.147 1.00 6.56  ? 374  MET A SD  1 
ATOM   2942 C  CE  . MET A 1 397 ? -11.923 -15.426 20.261 1.00 6.58  ? 374  MET A CE  1 
ATOM   2943 N  N   . TYR A 1 398 ? -9.384  -19.010 16.306 1.00 6.21  ? 375  TYR A N   1 
ATOM   2944 C  CA  . TYR A 1 398 ? -8.930  -19.920 15.224 1.00 6.04  ? 375  TYR A CA  1 
ATOM   2945 C  C   . TYR A 1 398 ? -7.583  -19.548 14.628 1.00 6.43  ? 375  TYR A C   1 
ATOM   2946 O  O   . TYR A 1 398 ? -7.178  -18.405 14.640 1.00 6.44  ? 375  TYR A O   1 
ATOM   2947 C  CB  . TYR A 1 398 ? -9.900  -19.847 14.031 1.00 7.03  ? 375  TYR A CB  1 
ATOM   2948 C  CG  . TYR A 1 398 ? -11.359 -20.243 14.189 1.00 6.88  ? 375  TYR A CG  1 
ATOM   2949 C  CD1 . TYR A 1 398 ? -12.322 -19.313 14.560 1.00 6.72  ? 375  TYR A CD1 1 
ATOM   2950 C  CD2 . TYR A 1 398 ? -11.782 -21.531 13.882 1.00 6.96  ? 375  TYR A CD2 1 
ATOM   2951 C  CE1 . TYR A 1 398 ? -13.658 -19.665 14.644 1.00 7.30  ? 375  TYR A CE1 1 
ATOM   2952 C  CE2 . TYR A 1 398 ? -13.115 -21.892 13.954 1.00 6.55  ? 375  TYR A CE2 1 
ATOM   2953 C  CZ  . TYR A 1 398 ? -14.054 -20.954 14.336 1.00 6.67  ? 375  TYR A CZ  1 
ATOM   2954 O  OH  . TYR A 1 398 ? -15.362 -21.316 14.399 1.00 7.73  ? 375  TYR A OH  1 
ATOM   2955 N  N   . GLU A 1 399 ? -6.922  -20.556 14.060 1.00 6.23  ? 376  GLU A N   1 
ATOM   2956 C  CA  . GLU A 1 399 ? -5.628  -20.401 13.413 1.00 6.56  ? 376  GLU A CA  1 
ATOM   2957 C  C   . GLU A 1 399 ? -5.604  -21.296 12.178 1.00 6.68  ? 376  GLU A C   1 
ATOM   2958 O  O   . GLU A 1 399 ? -5.861  -22.498 12.294 1.00 7.98  ? 376  GLU A O   1 
ATOM   2959 C  CB  . GLU A 1 399 ? -4.525  -20.785 14.381 1.00 6.87  ? 376  GLU A CB  1 
ATOM   2960 C  CG  . GLU A 1 399 ? -3.124  -20.620 13.814 1.00 7.36  ? 376  GLU A CG  1 
ATOM   2961 C  CD  . GLU A 1 399 ? -2.080  -21.123 14.752 1.00 7.15  ? 376  GLU A CD  1 
ATOM   2962 O  OE1 . GLU A 1 399 ? -2.404  -21.705 15.815 1.00 7.17  ? 376  GLU A OE1 1 
ATOM   2963 O  OE2 . GLU A 1 399 ? -0.879  -20.902 14.417 1.00 8.04  ? 376  GLU A OE2 1 
ATOM   2964 N  N   . TYR A 1 400 ? -5.316  -20.729 11.016 1.00 6.42  ? 377  TYR A N   1 
ATOM   2965 C  CA  . TYR A 1 400 ? -5.175  -21.470 9.778  1.00 6.74  ? 377  TYR A CA  1 
ATOM   2966 C  C   . TYR A 1 400 ? -3.944  -20.958 9.040  1.00 7.05  ? 377  TYR A C   1 
ATOM   2967 O  O   . TYR A 1 400 ? -3.754  -19.755 8.921  1.00 7.39  ? 377  TYR A O   1 
ATOM   2968 C  CB  . TYR A 1 400 ? -6.383  -21.215 8.861  1.00 7.26  ? 377  TYR A CB  1 
ATOM   2969 C  CG  . TYR A 1 400 ? -6.217  -21.840 7.473  1.00 7.47  ? 377  TYR A CG  1 
ATOM   2970 C  CD1 . TYR A 1 400 ? -5.587  -21.113 6.468  1.00 8.20  ? 377  TYR A CD1 1 
ATOM   2971 C  CD2 . TYR A 1 400 ? -6.563  -23.160 7.202  1.00 8.91  ? 377  TYR A CD2 1 
ATOM   2972 C  CE1 . TYR A 1 400 ? -5.315  -21.668 5.235  1.00 9.20  ? 377  TYR A CE1 1 
ATOM   2973 C  CE2 . TYR A 1 400 ? -6.318  -23.716 5.949  1.00 8.93  ? 377  TYR A CE2 1 
ATOM   2974 C  CZ  . TYR A 1 400 ? -5.704  -22.952 4.992  1.00 9.75  ? 377  TYR A CZ  1 
ATOM   2975 O  OH  . TYR A 1 400 ? -5.366  -23.417 3.736  1.00 11.28 ? 377  TYR A OH  1 
ATOM   2976 N  N   . GLY A 1 401 ? -3.117  -21.859 8.501  1.00 7.38  ? 378  GLY A N   1 
ATOM   2977 C  CA  . GLY A 1 401 ? -2.096  -21.475 7.543  1.00 7.49  ? 378  GLY A CA  1 
ATOM   2978 C  C   . GLY A 1 401 ? -0.916  -20.691 8.126  1.00 7.55  ? 378  GLY A C   1 
ATOM   2979 O  O   . GLY A 1 401 ? -0.321  -19.917 7.395  1.00 8.71  ? 378  GLY A O   1 
ATOM   2980 N  N   . THR A 1 402 ? -0.594  -20.854 9.392  1.00 7.11  ? 379  THR A N   1 
ATOM   2981 C  CA  . THR A 1 402 ? 0.562   -20.189 10.004 1.00 7.94  ? 379  THR A CA  1 
ATOM   2982 C  C   . THR A 1 402 ? 1.872   -20.586 9.342  1.00 8.92  ? 379  THR A C   1 
ATOM   2983 O  O   . THR A 1 402 ? 2.124   -21.776 9.169  1.00 9.32  ? 379  THR A O   1 
ATOM   2984 C  CB  . THR A 1 402 ? 0.600   -20.475 11.495 1.00 7.79  ? 379  THR A CB  1 
ATOM   2985 O  OG1 . THR A 1 402 ? -0.572  -19.854 12.020 1.00 8.17  ? 379  THR A OG1 1 
ATOM   2986 C  CG2 . THR A 1 402 ? 1.804   -19.884 12.200 1.00 8.26  ? 379  THR A CG2 1 
ATOM   2987 N  N   . THR A 1 403 ? 2.721   -19.604 9.090  1.00 8.33  ? 380  THR A N   1 
ATOM   2988 C  CA  . THR A 1 403 ? 4.147   -19.820 8.815  1.00 8.57  ? 380  THR A CA  1 
ATOM   2989 C  C   . THR A 1 403 ? 4.909   -19.340 10.051 1.00 8.27  ? 380  THR A C   1 
ATOM   2990 O  O   . THR A 1 403 ? 4.853   -18.160 10.384 1.00 8.62  ? 380  THR A O   1 
ATOM   2991 C  CB  . THR A 1 403 ? 4.605   -19.051 7.573  1.00 9.71  ? 380  THR A CB  1 
ATOM   2992 O  OG1 . THR A 1 403 ? 3.904   -19.579 6.441  1.00 12.04 ? 380  THR A OG1 1 
ATOM   2993 C  CG2 . THR A 1 403 ? 6.114   -19.164 7.358  1.00 11.30 ? 380  THR A CG2 1 
ATOM   2994 N  N   . GLU A 1 404 ? 5.684   -20.222 10.648 1.00 8.12  ? 381  GLU A N   1 
ATOM   2995 C  CA  . GLU A 1 404 ? 6.578   -19.877 11.724 1.00 7.59  ? 381  GLU A CA  1 
ATOM   2996 C  C   . GLU A 1 404 ? 7.957   -19.651 11.130 1.00 8.57  ? 381  GLU A C   1 
ATOM   2997 O  O   . GLU A 1 404 ? 8.602   -20.610 10.644 1.00 9.76  ? 381  GLU A O   1 
ATOM   2998 C  CB  . GLU A 1 404 ? 6.672   -21.011 12.727 1.00 8.25  ? 381  GLU A CB  1 
ATOM   2999 C  CG  . GLU A 1 404 ? 5.377   -21.259 13.478 1.00 7.74  ? 381  GLU A CG  1 
ATOM   3000 C  CD  . GLU A 1 404 ? 5.127   -20.346 14.657 1.00 8.12  ? 381  GLU A CD  1 
ATOM   3001 O  OE1 . GLU A 1 404 ? 4.136   -20.642 15.364 1.00 8.17  ? 381  GLU A OE1 1 
ATOM   3002 O  OE2 . GLU A 1 404 ? 5.846   -19.342 14.818 1.00 7.85  ? 381  GLU A OE2 1 
ATOM   3003 N  N   . SER A 1 405 ? 8.460   -18.435 11.140 1.00 7.83  ? 382  SER A N   1 
ATOM   3004 C  CA  . SER A 1 405 ? 9.795   -18.177 10.598 1.00 8.31  ? 382  SER A CA  1 
ATOM   3005 C  C   . SER A 1 405 ? 10.853  -18.910 11.396 1.00 9.30  ? 382  SER A C   1 
ATOM   3006 O  O   . SER A 1 405 ? 11.943  -19.169 10.848 1.00 10.31 ? 382  SER A O   1 
ATOM   3007 C  CB  . SER A 1 405 ? 10.022  -16.679 10.538 1.00 8.85  ? 382  SER A CB  1 
ATOM   3008 O  OG  . SER A 1 405 ? 9.120   -16.051 9.633  1.00 11.30 ? 382  SER A OG  1 
ATOM   3009 N  N   . SER A 1 406 ? 10.616  -19.253 12.662 1.00 8.75  ? 383  SER A N   1 
ATOM   3010 C  CA  . SER A 1 406 ? 11.565  -20.048 13.451 1.00 9.42  ? 383  SER A CA  1 
ATOM   3011 C  C   . SER A 1 406 ? 11.609  -21.501 12.991 1.00 11.05 ? 383  SER A C   1 
ATOM   3012 O  O   . SER A 1 406 ? 12.480  -22.250 13.457 1.00 12.04 ? 383  SER A O   1 
ATOM   3013 C  CB  . SER A 1 406 ? 11.274  -20.019 14.909 1.00 9.61  ? 383  SER A CB  1 
ATOM   3014 O  OG  . SER A 1 406 ? 10.005  -20.589 15.182 1.00 10.15 ? 383  SER A OG  1 
ATOM   3015 N  N   . GLY A 1 407 ? 10.618  -21.968 12.243 1.00 10.12 ? 384  GLY A N   1 
ATOM   3016 C  CA  . GLY A 1 407 ? 10.542  -23.369 11.861 1.00 11.11 ? 384  GLY A CA  1 
ATOM   3017 C  C   . GLY A 1 407 ? 9.865   -24.286 12.868 1.00 12.16 ? 384  GLY A C   1 
ATOM   3018 O  O   . GLY A 1 407 ? 9.745   -25.486 12.616 1.00 14.45 ? 384  GLY A O   1 
ATOM   3019 N  N   . VAL A 1 408 ? 9.444   -23.802 14.032 1.00 10.69 ? 385  VAL A N   1 
ATOM   3020 C  CA  . VAL A 1 408 ? 8.720   -24.629 14.992 1.00 10.77 ? 385  VAL A CA  1 
ATOM   3021 C  C   . VAL A 1 408 ? 7.325   -24.932 14.490 1.00 10.02 ? 385  VAL A C   1 
ATOM   3022 O  O   . VAL A 1 408 ? 6.825   -24.270 13.585 1.00 11.39 ? 385  VAL A O   1 
ATOM   3023 C  CB  . VAL A 1 408 ? 8.662   -23.986 16.370 1.00 11.87 ? 385  VAL A CB  1 
ATOM   3024 C  CG1 . VAL A 1 408 ? 10.061  -23.700 16.863 1.00 16.00 ? 385  VAL A CG1 1 
ATOM   3025 C  CG2 . VAL A 1 408 ? 7.753   -22.754 16.396 1.00 12.47 ? 385  VAL A CG2 1 
ATOM   3026 N  N   . ASP A 1 409 ? 6.736   -25.975 15.080 1.00 10.54 ? 386  ASP A N   1 
ATOM   3027 C  CA  . ASP A 1 409 ? 5.340   -26.295 14.852 1.00 11.58 ? 386  ASP A CA  1 
ATOM   3028 C  C   . ASP A 1 409 ? 4.654   -26.455 16.194 1.00 11.31 ? 386  ASP A C   1 
ATOM   3029 O  O   . ASP A 1 409 ? 4.791   -27.471 16.852 1.00 11.53 ? 386  ASP A O   1 
ATOM   3030 C  CB  . ASP A 1 409 ? 5.173   -27.567 14.042 1.00 13.48 ? 386  ASP A CB  1 
ATOM   3031 C  CG  . ASP A 1 409 ? 3.738   -27.940 13.758 1.00 17.04 ? 386  ASP A CG  1 
ATOM   3032 O  OD1 . ASP A 1 409 ? 2.825   -27.338 14.346 1.00 15.00 ? 386  ASP A OD1 1 
ATOM   3033 O  OD2 . ASP A 1 409 ? 3.546   -28.874 12.969 1.00 21.60 ? 386  ASP A OD2 1 
ATOM   3034 N  N   . ASN A 1 410 ? 3.918   -25.407 16.617 1.00 9.55  ? 387  ASN A N   1 
ATOM   3035 C  CA  . ASN A 1 410 ? 3.267   -25.424 17.908 1.00 9.36  ? 387  ASN A CA  1 
ATOM   3036 C  C   . ASN A 1 410 ? 1.799   -25.804 17.828 1.00 9.31  ? 387  ASN A C   1 
ATOM   3037 O  O   . ASN A 1 410 ? 1.063   -25.644 18.817 1.00 9.95  ? 387  ASN A O   1 
ATOM   3038 C  CB  . ASN A 1 410 ? 3.377   -24.049 18.587 1.00 9.45  ? 387  ASN A CB  1 
ATOM   3039 C  CG  . ASN A 1 410 ? 4.788   -23.769 19.042 1.00 9.60  ? 387  ASN A CG  1 
ATOM   3040 O  OD1 . ASN A 1 410 ? 5.487   -24.669 19.521 1.00 11.74 ? 387  ASN A OD1 1 
ATOM   3041 N  ND2 . ASN A 1 410 ? 5.198   -22.507 18.945 1.00 9.81  ? 387  ASN A ND2 1 
ATOM   3042 N  N   A SER A 1 411 ? 1.346   -26.345 16.703 0.50 9.49  ? 388  SER A N   1 
ATOM   3043 N  N   B SER A 1 411 ? 1.375   -26.366 16.699 0.50 9.34  ? 388  SER A N   1 
ATOM   3044 C  CA  A SER A 1 411 ? -0.081  -26.624 16.548 0.50 11.12 ? 388  SER A CA  1 
ATOM   3045 C  CA  B SER A 1 411 ? -0.039  -26.657 16.475 0.50 10.91 ? 388  SER A CA  1 
ATOM   3046 C  C   A SER A 1 411 ? -0.600  -27.518 17.679 0.50 11.31 ? 388  SER A C   1 
ATOM   3047 C  C   B SER A 1 411 ? -0.619  -27.571 17.554 0.50 11.33 ? 388  SER A C   1 
ATOM   3048 O  O   A SER A 1 411 ? -1.673  -27.301 18.255 0.50 11.47 ? 388  SER A O   1 
ATOM   3049 O  O   B SER A 1 411 ? -1.782  -27.412 17.922 0.50 12.02 ? 388  SER A O   1 
ATOM   3050 C  CB  A SER A 1 411 ? -0.352  -27.243 15.201 0.50 11.70 ? 388  SER A CB  1 
ATOM   3051 C  CB  B SER A 1 411 ? -0.264  -27.249 15.109 0.50 11.16 ? 388  SER A CB  1 
ATOM   3052 O  OG  A SER A 1 411 ? 0.008   -26.387 14.121 0.50 13.67 ? 388  SER A OG  1 
ATOM   3053 O  OG  B SER A 1 411 ? 0.523   -28.418 14.903 0.50 12.02 ? 388  SER A OG  1 
ATOM   3054 N  N   . SER A 1 412 ? 0.147   -28.554 18.038 1.00 11.47 ? 389  SER A N   1 
ATOM   3055 C  CA  . SER A 1 412 ? -0.361  -29.487 19.040 1.00 11.07 ? 389  SER A CA  1 
ATOM   3056 C  C   . SER A 1 412 ? -0.467  -28.869 20.415 1.00 10.87 ? 389  SER A C   1 
ATOM   3057 O  O   . SER A 1 412 ? -1.142  -29.438 21.287 1.00 13.40 ? 389  SER A O   1 
ATOM   3058 C  CB  . SER A 1 412 ? 0.454   -30.766 19.111 1.00 13.87 ? 389  SER A CB  1 
ATOM   3059 O  OG  . SER A 1 412 ? 1.761   -30.489 19.540 1.00 16.52 ? 389  SER A OG  1 
ATOM   3060 N  N   . ALA A 1 413 ? 0.257   -27.781 20.674 1.00 9.26  ? 390  ALA A N   1 
ATOM   3061 C  CA  . ALA A 1 413 ? 0.316   -27.129 21.960 1.00 9.89  ? 390  ALA A CA  1 
ATOM   3062 C  C   . ALA A 1 413 ? -0.775  -26.062 22.153 1.00 8.35  ? 390  ALA A C   1 
ATOM   3063 O  O   . ALA A 1 413 ? -0.994  -25.610 23.277 1.00 8.82  ? 390  ALA A O   1 
ATOM   3064 C  CB  . ALA A 1 413 ? 1.689   -26.529 22.188 1.00 10.30 ? 390  ALA A CB  1 
ATOM   3065 N  N   . ARG A 1 414 ? -1.416  -25.644 21.078 1.00 7.93  ? 391  ARG A N   1 
ATOM   3066 C  CA  . ARG A 1 414 ? -2.352  -24.531 21.183 1.00 7.83  ? 391  ARG A CA  1 
ATOM   3067 C  C   . ARG A 1 414 ? -3.444  -24.858 22.182 1.00 8.04  ? 391  ARG A C   1 
ATOM   3068 O  O   . ARG A 1 414 ? -4.069  -25.922 22.088 1.00 7.57  ? 391  ARG A O   1 
ATOM   3069 C  CB  . ARG A 1 414 ? -2.965  -24.251 19.813 1.00 7.49  ? 391  ARG A CB  1 
ATOM   3070 C  CG  . ARG A 1 414 ? -1.980  -23.798 18.767 1.00 7.26  ? 391  ARG A CG  1 
ATOM   3071 C  CD  . ARG A 1 414 ? -1.366  -22.451 19.068 1.00 7.56  ? 391  ARG A CD  1 
ATOM   3072 N  NE  . ARG A 1 414 ? -0.667  -21.941 17.888 1.00 7.19  ? 391  ARG A NE  1 
ATOM   3073 C  CZ  . ARG A 1 414 ? 0.505   -21.330 17.897 1.00 6.64  ? 391  ARG A CZ  1 
ATOM   3074 N  NH1 . ARG A 1 414 ? 1.201   -21.177 19.006 1.00 7.41  ? 391  ARG A NH1 1 
ATOM   3075 N  NH2 . ARG A 1 414 ? 0.939   -20.818 16.787 1.00 6.71  ? 391  ARG A NH2 1 
ATOM   3076 N  N   . ILE A 1 415 ? -3.707  -23.928 23.115 1.00 6.96  ? 392  ILE A N   1 
ATOM   3077 C  CA  . ILE A 1 415 ? -4.816  -24.009 24.079 1.00 6.80  ? 392  ILE A CA  1 
ATOM   3078 C  C   . ILE A 1 415 ? -4.955  -25.424 24.618 1.00 7.98  ? 392  ILE A C   1 
ATOM   3079 O  O   . ILE A 1 415 ? -6.084  -25.921 24.832 1.00 7.86  ? 392  ILE A O   1 
ATOM   3080 C  CB  . ILE A 1 415 ? -6.114  -23.446 23.493 1.00 7.07  ? 392  ILE A CB  1 
ATOM   3081 C  CG1 . ILE A 1 415 ? -6.590  -24.113 22.222 1.00 7.37  ? 392  ILE A CG1 1 
ATOM   3082 C  CG2 . ILE A 1 415 ? -5.962  -21.945 23.331 1.00 6.90  ? 392  ILE A CG2 1 
ATOM   3083 C  CD1 . ILE A 1 415 ? -7.997  -23.746 21.825 1.00 7.85  ? 392  ILE A CD1 1 
ATOM   3084 N  N   . ALA A 1 416 ? -3.839  -26.042 25.022 1.00 8.05  ? 393  ALA A N   1 
ATOM   3085 C  CA  . ALA A 1 416 ? -3.910  -27.405 25.548 1.00 9.27  ? 393  ALA A CA  1 
ATOM   3086 C  C   . ALA A 1 416 ? -4.755  -27.499 26.818 1.00 9.64  ? 393  ALA A C   1 
ATOM   3087 O  O   . ALA A 1 416 ? -5.280  -28.622 27.078 1.00 12.37 ? 393  ALA A O   1 
ATOM   3088 C  CB  . ALA A 1 416 ? -2.516  -27.890 25.835 1.00 10.71 ? 393  ALA A CB  1 
ATOM   3089 N  N   . SER A 1 417 ? -4.876  -26.436 27.588 1.00 9.26  ? 394  SER A N   1 
ATOM   3090 C  CA  . SER A 1 417 ? -5.605  -26.434 28.847 1.00 9.58  ? 394  SER A CA  1 
ATOM   3091 C  C   . SER A 1 417 ? -7.090  -26.103 28.668 1.00 9.72  ? 394  SER A C   1 
ATOM   3092 O  O   . SER A 1 417 ? -7.815  -26.114 29.670 1.00 10.82 ? 394  SER A O   1 
ATOM   3093 C  CB  . SER A 1 417 ? -4.977  -25.458 29.792 1.00 9.97  ? 394  SER A CB  1 
ATOM   3094 O  OG  . SER A 1 417 ? -5.166  -24.115 29.388 1.00 10.96 ? 394  SER A OG  1 
ATOM   3095 N  N   . TRP A 1 418 ? -7.560  -25.759 27.463 1.00 7.88  ? 395  TRP A N   1 
ATOM   3096 C  CA  . TRP A 1 418 ? -8.947  -25.396 27.231 1.00 7.89  ? 395  TRP A CA  1 
ATOM   3097 C  C   . TRP A 1 418 ? -9.780  -26.658 27.077 1.00 7.86  ? 395  TRP A C   1 
ATOM   3098 O  O   . TRP A 1 418 ? -9.338  -27.652 26.505 1.00 8.62  ? 395  TRP A O   1 
ATOM   3099 C  CB  . TRP A 1 418 ? -9.070  -24.472 26.023 1.00 7.67  ? 395  TRP A CB  1 
ATOM   3100 C  CG  . TRP A 1 418 ? -8.518  -23.086 26.269 1.00 6.86  ? 395  TRP A CG  1 
ATOM   3101 C  CD1 . TRP A 1 418 ? -7.646  -22.643 27.203 1.00 6.86  ? 395  TRP A CD1 1 
ATOM   3102 C  CD2 . TRP A 1 418 ? -8.846  -21.938 25.451 1.00 6.25  ? 395  TRP A CD2 1 
ATOM   3103 N  NE1 . TRP A 1 418 ? -7.407  -21.299 27.043 1.00 6.95  ? 395  TRP A NE1 1 
ATOM   3104 C  CE2 . TRP A 1 418 ? -8.103  -20.859 25.954 1.00 6.54  ? 395  TRP A CE2 1 
ATOM   3105 C  CE3 . TRP A 1 418 ? -9.669  -21.741 24.345 1.00 6.63  ? 395  TRP A CE3 1 
ATOM   3106 C  CZ2 . TRP A 1 418 ? -8.226  -19.582 25.400 1.00 6.39  ? 395  TRP A CZ2 1 
ATOM   3107 C  CZ3 . TRP A 1 418 ? -9.737  -20.487 23.770 1.00 6.41  ? 395  TRP A CZ3 1 
ATOM   3108 C  CH2 . TRP A 1 418 ? -9.052  -19.410 24.327 1.00 6.52  ? 395  TRP A CH2 1 
ATOM   3109 N  N   . THR A 1 419 ? -11.042 -26.574 27.469 1.00 7.37  ? 396  THR A N   1 
ATOM   3110 C  CA  . THR A 1 419 ? -11.903 -27.746 27.576 1.00 8.15  ? 396  THR A CA  1 
ATOM   3111 C  C   . THR A 1 419 ? -13.180 -27.639 26.757 1.00 8.39  ? 396  THR A C   1 
ATOM   3112 O  O   . THR A 1 419 ? -13.761 -28.679 26.435 1.00 9.84  ? 396  THR A O   1 
ATOM   3113 C  CB  . THR A 1 419 ? -12.221 -28.053 29.026 1.00 8.44  ? 396  THR A CB  1 
ATOM   3114 O  OG1 . THR A 1 419 ? -12.949 -26.942 29.545 1.00 9.29  ? 396  THR A OG1 1 
ATOM   3115 C  CG2 . THR A 1 419 ? -11.001 -28.324 29.860 1.00 8.11  ? 396  THR A CG2 1 
ATOM   3116 N  N   A THR A 1 420 ? -13.655 -26.449 26.378 0.50 8.98  ? 397  THR A N   1 
ATOM   3117 N  N   B THR A 1 420 ? -13.681 -26.443 26.479 0.50 8.44  ? 397  THR A N   1 
ATOM   3118 C  CA  A THR A 1 420 ? -14.909 -26.332 25.619 0.50 9.63  ? 397  THR A CA  1 
ATOM   3119 C  CA  B THR A 1 420 ? -14.886 -26.336 25.662 0.50 8.75  ? 397  THR A CA  1 
ATOM   3120 C  C   A THR A 1 420 ? -14.714 -25.853 24.187 0.50 9.65  ? 397  THR A C   1 
ATOM   3121 C  C   B THR A 1 420 ? -14.492 -26.115 24.194 0.50 8.66  ? 397  THR A C   1 
ATOM   3122 O  O   A THR A 1 420 ? -15.540 -26.102 23.325 0.50 10.92 ? 397  THR A O   1 
ATOM   3123 O  O   B THR A 1 420 ? -14.893 -26.868 23.275 0.50 7.94  ? 397  THR A O   1 
ATOM   3124 C  CB  A THR A 1 420 ? -15.905 -25.422 26.317 0.50 10.96 ? 397  THR A CB  1 
ATOM   3125 C  CB  B THR A 1 420 ? -15.811 -25.257 26.219 0.50 9.60  ? 397  THR A CB  1 
ATOM   3126 O  OG1 A THR A 1 420 ? -15.389 -24.110 26.526 0.50 14.07 ? 397  THR A OG1 1 
ATOM   3127 O  OG1 B THR A 1 420 ? -16.100 -25.555 27.597 0.50 11.05 ? 397  THR A OG1 1 
ATOM   3128 C  CG2 A THR A 1 420 ? -16.394 -26.140 27.558 0.50 9.91  ? 397  THR A CG2 1 
ATOM   3129 C  CG2 B THR A 1 420 ? -17.100 -25.266 25.406 0.50 10.01 ? 397  THR A CG2 1 
ATOM   3130 N  N   . TRP A 1 421 ? -13.692 -25.070 23.981 1.00 8.60  ? 398  TRP A N   1 
ATOM   3131 C  CA  . TRP A 1 421 ? -13.090 -24.783 22.680 1.00 7.72  ? 398  TRP A CA  1 
ATOM   3132 C  C   . TRP A 1 421 ? -11.689 -25.328 22.739 1.00 7.95  ? 398  TRP A C   1 
ATOM   3133 O  O   . TRP A 1 421 ? -10.867 -24.843 23.500 1.00 8.39  ? 398  TRP A O   1 
ATOM   3134 C  CB  . TRP A 1 421 ? -13.045 -23.291 22.421 1.00 7.32  ? 398  TRP A CB  1 
ATOM   3135 C  CG  . TRP A 1 421 ? -12.549 -22.963 21.044 1.00 7.25  ? 398  TRP A CG  1 
ATOM   3136 C  CD1 . TRP A 1 421 ? -11.315 -22.503 20.681 1.00 7.09  ? 398  TRP A CD1 1 
ATOM   3137 C  CD2 . TRP A 1 421 ? -13.336 -23.023 19.838 1.00 7.22  ? 398  TRP A CD2 1 
ATOM   3138 N  NE1 . TRP A 1 421 ? -11.272 -22.262 19.321 1.00 7.26  ? 398  TRP A NE1 1 
ATOM   3139 C  CE2 . TRP A 1 421 ? -12.520 -22.546 18.794 1.00 7.22  ? 398  TRP A CE2 1 
ATOM   3140 C  CE3 . TRP A 1 421 ? -14.676 -23.348 19.582 1.00 8.66  ? 398  TRP A CE3 1 
ATOM   3141 C  CZ2 . TRP A 1 421 ? -12.986 -22.437 17.490 1.00 7.94  ? 398  TRP A CZ2 1 
ATOM   3142 C  CZ3 . TRP A 1 421 ? -15.110 -23.297 18.271 1.00 9.22  ? 398  TRP A CZ3 1 
ATOM   3143 C  CH2 . TRP A 1 421 ? -14.279 -22.827 17.255 1.00 8.94  ? 398  TRP A CH2 1 
ATOM   3144 N  N   . THR A 1 422 ? -11.443 -26.456 22.060 1.00 8.82  ? 399  THR A N   1 
ATOM   3145 C  CA  . THR A 1 422 ? -10.214 -27.205 22.236 1.00 9.17  ? 399  THR A CA  1 
ATOM   3146 C  C   . THR A 1 422 ? -9.269  -27.000 21.047 1.00 8.22  ? 399  THR A C   1 
ATOM   3147 O  O   . THR A 1 422 ? -9.591  -26.384 20.043 1.00 8.31  ? 399  THR A O   1 
ATOM   3148 C  CB  . THR A 1 422 ? -10.535 -28.694 22.452 1.00 10.15 ? 399  THR A CB  1 
ATOM   3149 O  OG1 . THR A 1 422 ? -11.090 -29.233 21.266 1.00 11.96 ? 399  THR A OG1 1 
ATOM   3150 C  CG2 . THR A 1 422 ? -11.485 -28.925 23.612 1.00 10.92 ? 399  THR A CG2 1 
ATOM   3151 N  N   . THR A 1 423 ? -8.086  -27.585 21.187 1.00 8.44  ? 400  THR A N   1 
ATOM   3152 C  CA  . THR A 1 423 ? -7.063  -27.473 20.142 1.00 7.89  ? 400  THR A CA  1 
ATOM   3153 C  C   . THR A 1 423 ? -7.604  -27.775 18.760 1.00 9.43  ? 400  THR A C   1 
ATOM   3154 O  O   . THR A 1 423 ? -7.347  -27.067 17.784 1.00 9.09  ? 400  THR A O   1 
ATOM   3155 C  CB  . THR A 1 423 ? -5.905  -28.410 20.480 1.00 8.38  ? 400  THR A CB  1 
ATOM   3156 O  OG1 . THR A 1 423 ? -5.502  -28.188 21.835 1.00 9.09  ? 400  THR A OG1 1 
ATOM   3157 C  CG2 . THR A 1 423 ? -4.743  -28.261 19.523 1.00 8.92  ? 400  THR A CG2 1 
ATOM   3158 N  N   . SER A 1 424 ? -8.395  -28.854 18.632 1.00 9.76  ? 401  SER A N   1 
ATOM   3159 C  CA  . SER A 1 424 ? -8.890  -29.288 17.336 1.00 10.55 ? 401  SER A CA  1 
ATOM   3160 C  C   . SER A 1 424 ? -9.955  -28.349 16.793 1.00 9.45  ? 401  SER A C   1 
ATOM   3161 O  O   . SER A 1 424 ? -10.156 -28.321 15.578 1.00 11.10 ? 401  SER A O   1 
ATOM   3162 C  CB  . SER A 1 424 ? -9.458  -30.710 17.402 1.00 12.17 ? 401  SER A CB  1 
ATOM   3163 O  OG  . SER A 1 424 ? -10.530 -30.815 18.280 1.00 15.55 ? 401  SER A OG  1 
ATOM   3164 N  N   . ASP A 1 425 ? -10.649 -27.592 17.635 1.00 8.46  ? 402  ASP A N   1 
ATOM   3165 C  CA  . ASP A 1 425 ? -11.542 -26.540 17.177 1.00 8.33  ? 402  ASP A CA  1 
ATOM   3166 C  C   . ASP A 1 425 ? -10.770 -25.352 16.615 1.00 7.72  ? 402  ASP A C   1 
ATOM   3167 O  O   . ASP A 1 425 ? -11.197 -24.719 15.662 1.00 8.05  ? 402  ASP A O   1 
ATOM   3168 C  CB  . ASP A 1 425 ? -12.410 -26.048 18.331 1.00 8.69  ? 402  ASP A CB  1 
ATOM   3169 C  CG  . ASP A 1 425 ? -13.360 -27.109 18.858 1.00 9.42  ? 402  ASP A CG  1 
ATOM   3170 O  OD1 . ASP A 1 425 ? -13.968 -27.830 18.031 1.00 11.51 ? 402  ASP A OD1 1 
ATOM   3171 O  OD2 . ASP A 1 425 ? -13.480 -27.228 20.076 1.00 10.53 ? 402  ASP A OD2 1 
ATOM   3172 N  N   . SER A 1 426 ? -9.639  -25.019 17.233 1.00 7.36  ? 403  SER A N   1 
ATOM   3173 C  CA  . SER A 1 426 ? -8.879  -23.830 16.880 1.00 7.09  ? 403  SER A CA  1 
ATOM   3174 C  C   . SER A 1 426 ? -8.015  -24.012 15.645 1.00 7.24  ? 403  SER A C   1 
ATOM   3175 O  O   . SER A 1 426 ? -7.990  -23.138 14.800 1.00 7.35  ? 403  SER A O   1 
ATOM   3176 C  CB  . SER A 1 426 ? -8.041  -23.445 18.071 1.00 7.45  ? 403  SER A CB  1 
ATOM   3177 O  OG  . SER A 1 426 ? -7.232  -22.306 17.785 1.00 7.90  ? 403  SER A OG  1 
ATOM   3178 N  N   . VAL A 1 427 ? -7.236  -25.103 15.629 1.00 7.62  ? 404  VAL A N   1 
ATOM   3179 C  CA  . VAL A 1 427 ? -6.197  -25.288 14.630 1.00 8.38  ? 404  VAL A CA  1 
ATOM   3180 C  C   . VAL A 1 427 ? -6.819  -25.946 13.409 1.00 8.76  ? 404  VAL A C   1 
ATOM   3181 O  O   . VAL A 1 427 ? -7.073  -27.148 13.416 1.00 10.65 ? 404  VAL A O   1 
ATOM   3182 C  CB  . VAL A 1 427 ? -5.034  -26.085 15.218 1.00 10.30 ? 404  VAL A CB  1 
ATOM   3183 C  CG1 . VAL A 1 427 ? -3.953  -26.371 14.159 1.00 13.72 ? 404  VAL A CG1 1 
ATOM   3184 C  CG2 . VAL A 1 427 ? -4.441  -25.341 16.424 1.00 10.96 ? 404  VAL A CG2 1 
ATOM   3185 N  N   . LEU A 1 428 ? -7.084  -25.138 12.396 1.00 8.52  ? 405  LEU A N   1 
ATOM   3186 C  CA  . LEU A 1 428 ? -7.832  -25.578 11.233 1.00 8.57  ? 405  LEU A CA  1 
ATOM   3187 C  C   . LEU A 1 428 ? -6.914  -26.194 10.191 1.00 10.27 ? 405  LEU A C   1 
ATOM   3188 O  O   . LEU A 1 428 ? -5.872  -25.632 9.875  1.00 12.47 ? 405  LEU A O   1 
ATOM   3189 C  CB  . LEU A 1 428 ? -8.563  -24.384 10.635 1.00 7.75  ? 405  LEU A CB  1 
ATOM   3190 C  CG  . LEU A 1 428 ? -9.605  -23.678 11.506 1.00 8.67  ? 405  LEU A CG  1 
ATOM   3191 C  CD1 . LEU A 1 428 ? -10.184 -22.493 10.781 1.00 9.86  ? 405  LEU A CD1 1 
ATOM   3192 C  CD2 . LEU A 1 428 ? -10.669 -24.658 11.950 1.00 9.27  ? 405  LEU A CD2 1 
ATOM   3193 N  N   . THR A 1 429 ? -7.415  -27.285 9.594  1.00 11.92 ? 406  THR A N   1 
ATOM   3194 C  CA  . THR A 1 429 ? -6.697  -27.911 8.490  1.00 14.14 ? 406  THR A CA  1 
ATOM   3195 C  C   . THR A 1 429 ? -7.260  -27.484 7.131  1.00 13.32 ? 406  THR A C   1 
ATOM   3196 O  O   . THR A 1 429 ? -6.609  -27.699 6.106  1.00 14.56 ? 406  THR A O   1 
ATOM   3197 C  CB  . THR A 1 429 ? -6.647  -29.443 8.605  1.00 16.27 ? 406  THR A CB  1 
ATOM   3198 O  OG1 . THR A 1 429 ? -7.977  -29.924 8.554  1.00 18.61 ? 406  THR A OG1 1 
ATOM   3199 C  CG2 . THR A 1 429 ? -6.080  -29.887 9.937  1.00 19.63 ? 406  THR A CG2 1 
ATOM   3200 N  N   . THR A 1 430 ? -8.489  -26.961 7.097  1.00 11.42 ? 407  THR A N   1 
ATOM   3201 C  CA  . THR A 1 430 ? -9.140  -26.423 5.914  1.00 10.69 ? 407  THR A CA  1 
ATOM   3202 C  C   . THR A 1 430 ? -9.717  -25.065 6.323  1.00 9.25  ? 407  THR A C   1 
ATOM   3203 O  O   . THR A 1 430 ? -10.024 -24.855 7.529  1.00 9.73  ? 407  THR A O   1 
ATOM   3204 C  CB  . THR A 1 430 ? -10.252 -27.363 5.449  1.00 12.11 ? 407  THR A CB  1 
ATOM   3205 O  OG1 . THR A 1 430 ? -11.275 -27.417 6.426  1.00 13.67 ? 407  THR A OG1 1 
ATOM   3206 C  CG2 . THR A 1 430 ? -9.713  -28.747 5.130  1.00 13.57 ? 407  THR A CG2 1 
ATOM   3207 N  N   . PRO A 1 431 ? -9.874  -24.120 5.392  1.00 9.00  ? 408  PRO A N   1 
ATOM   3208 C  CA  . PRO A 1 431 ? -10.217 -22.753 5.781  1.00 9.44  ? 408  PRO A CA  1 
ATOM   3209 C  C   . PRO A 1 431 ? -11.717 -22.525 5.959  1.00 8.33  ? 408  PRO A C   1 
ATOM   3210 O  O   . PRO A 1 431 ? -12.306 -21.705 5.274  1.00 9.21  ? 408  PRO A O   1 
ATOM   3211 C  CB  . PRO A 1 431 ? -9.603  -21.951 4.632  1.00 10.05 ? 408  PRO A CB  1 
ATOM   3212 C  CG  . PRO A 1 431 ? -9.850  -22.876 3.425  1.00 9.62  ? 408  PRO A CG  1 
ATOM   3213 C  CD  . PRO A 1 431 ? -9.503  -24.248 3.959  1.00 10.21 ? 408  PRO A CD  1 
ATOM   3214 N  N   . TYR A 1 432 ? -12.305 -23.237 6.924  1.00 9.24  ? 409  TYR A N   1 
ATOM   3215 C  CA  . TYR A 1 432 ? -13.729 -23.172 7.201  1.00 8.96  ? 409  TYR A CA  1 
ATOM   3216 C  C   . TYR A 1 432 ? -13.947 -23.069 8.701  1.00 9.52  ? 409  TYR A C   1 
ATOM   3217 O  O   . TYR A 1 432 ? -13.335 -23.807 9.465  1.00 9.54  ? 409  TYR A O   1 
ATOM   3218 C  CB  . TYR A 1 432 ? -14.466 -24.415 6.647  1.00 10.40 ? 409  TYR A CB  1 
ATOM   3219 C  CG  . TYR A 1 432 ? -14.383 -24.514 5.136  1.00 10.92 ? 409  TYR A CG  1 
ATOM   3220 C  CD1 . TYR A 1 432 ? -13.307 -25.093 4.511  1.00 12.47 ? 409  TYR A CD1 1 
ATOM   3221 C  CD2 . TYR A 1 432 ? -15.313 -23.909 4.329  1.00 10.90 ? 409  TYR A CD2 1 
ATOM   3222 C  CE1 . TYR A 1 432 ? -13.186 -25.130 3.135  1.00 13.74 ? 409  TYR A CE1 1 
ATOM   3223 C  CE2 . TYR A 1 432 ? -15.220 -23.922 2.947  1.00 13.48 ? 409  TYR A CE2 1 
ATOM   3224 C  CZ  . TYR A 1 432 ? -14.152 -24.552 2.356  1.00 14.63 ? 409  TYR A CZ  1 
ATOM   3225 O  OH  . TYR A 1 432 ? -14.023 -24.582 0.981  1.00 15.97 ? 409  TYR A OH  1 
ATOM   3226 N  N   . LEU A 1 433 ? -14.823 -22.165 9.113  1.00 9.20  ? 410  LEU A N   1 
ATOM   3227 C  CA  . LEU A 1 433 ? -15.171 -21.953 10.510 1.00 9.14  ? 410  LEU A CA  1 
ATOM   3228 C  C   . LEU A 1 433 ? -16.212 -22.960 10.969 1.00 10.59 ? 410  LEU A C   1 
ATOM   3229 O  O   . LEU A 1 433 ? -16.725 -23.751 10.161 1.00 11.12 ? 410  LEU A O   1 
ATOM   3230 C  CB  . LEU A 1 433 ? -15.629 -20.505 10.693 1.00 9.14  ? 410  LEU A CB  1 
ATOM   3231 C  CG  . LEU A 1 433 ? -14.645 -19.453 10.173 1.00 8.76  ? 410  LEU A CG  1 
ATOM   3232 C  CD1 . LEU A 1 433 ? -15.197 -18.113 10.486 1.00 9.72  ? 410  LEU A CD1 1 
ATOM   3233 C  CD2 . LEU A 1 433 ? -13.302 -19.621 10.772 1.00 7.91  ? 410  LEU A CD2 1 
ATOM   3234 N  N   . ALA A 1 434 ? -16.565 -22.960 12.257 1.00 10.42 ? 411  ALA A N   1 
ATOM   3235 C  CA  . ALA A 1 434 ? -17.411 -24.028 12.797 1.00 11.37 ? 411  ALA A CA  1 
ATOM   3236 C  C   . ALA A 1 434 ? -18.799 -24.010 12.172 1.00 12.10 ? 411  ALA A C   1 
ATOM   3237 O  O   . ALA A 1 434 ? -19.407 -25.098 12.075 1.00 14.76 ? 411  ALA A O   1 
ATOM   3238 C  CB  . ALA A 1 434 ? -17.462 -23.887 14.307 1.00 12.23 ? 411  ALA A CB  1 
ATOM   3239 N  N   . ASP A 1 435 ? -19.314 -22.870 11.758 1.00 12.26 ? 412  ASP A N   1 
ATOM   3240 C  CA  . ASP A 1 435 ? -20.625 -22.804 11.132 1.00 12.66 ? 412  ASP A CA  1 
ATOM   3241 C  C   . ASP A 1 435 ? -20.547 -23.143 9.645  1.00 13.00 ? 412  ASP A C   1 
ATOM   3242 O  O   . ASP A 1 435 ? -21.559 -22.979 8.942  1.00 15.02 ? 412  ASP A O   1 
ATOM   3243 C  CB  . ASP A 1 435 ? -21.261 -21.438 11.339 1.00 12.52 ? 412  ASP A CB  1 
ATOM   3244 C  CG  . ASP A 1 435 ? -20.533 -20.266 10.691 1.00 12.99 ? 412  ASP A CG  1 
ATOM   3245 O  OD1 . ASP A 1 435 ? -19.552 -20.528 9.965  1.00 12.56 ? 412  ASP A OD1 1 
ATOM   3246 O  OD2 . ASP A 1 435 ? -21.012 -19.138 10.890 1.00 14.49 ? 412  ASP A OD2 1 
ATOM   3247 N  N   . GLY A 1 436 ? -19.394 -23.552 9.120  1.00 11.86 ? 413  GLY A N   1 
ATOM   3248 C  CA  . GLY A 1 436 ? -19.262 -23.904 7.717  1.00 12.17 ? 413  GLY A CA  1 
ATOM   3249 C  C   . GLY A 1 436 ? -18.756 -22.765 6.849  1.00 11.10 ? 413  GLY A C   1 
ATOM   3250 O  O   . GLY A 1 436 ? -18.477 -22.958 5.663  1.00 12.61 ? 413  GLY A O   1 
ATOM   3251 N  N   . THR A 1 437 ? -18.666 -21.531 7.401  1.00 11.41 ? 414  THR A N   1 
ATOM   3252 C  CA  . THR A 1 437 ? -18.270 -20.374 6.604  1.00 11.06 ? 414  THR A CA  1 
ATOM   3253 C  C   . THR A 1 437 ? -16.831 -20.524 6.122  1.00 9.90  ? 414  THR A C   1 
ATOM   3254 O  O   . THR A 1 437 ? -15.889 -20.739 6.906  1.00 10.40 ? 414  THR A O   1 
ATOM   3255 C  CB  . THR A 1 437 ? -18.429 -19.088 7.428  1.00 12.17 ? 414  THR A CB  1 
ATOM   3256 O  OG1 . THR A 1 437 ? -19.794 -18.964 7.837  1.00 13.79 ? 414  THR A OG1 1 
ATOM   3257 C  CG2 . THR A 1 437 ? -18.025 -17.849 6.666  1.00 14.44 ? 414  THR A CG2 1 
ATOM   3258 N  N   . LYS A 1 438 ? -16.629 -20.268 4.840  1.00 9.56  ? 415  LYS A N   1 
ATOM   3259 C  CA  . LYS A 1 438 ? -15.300 -20.211 4.291  1.00 9.05  ? 415  LYS A CA  1 
ATOM   3260 C  C   . LYS A 1 438 ? -14.599 -18.936 4.762  1.00 8.39  ? 415  LYS A C   1 
ATOM   3261 O  O   . LYS A 1 438 ? -15.163 -17.844 4.766  1.00 9.02  ? 415  LYS A O   1 
ATOM   3262 C  CB  . LYS A 1 438 ? -15.390 -20.267 2.765  1.00 9.34  ? 415  LYS A CB  1 
ATOM   3263 C  CG  . LYS A 1 438 ? -14.053 -20.543 2.097  1.00 9.71  ? 415  LYS A CG  1 
ATOM   3264 C  CD  . LYS A 1 438 ? -14.241 -20.813 0.596  1.00 12.05 ? 415  LYS A CD  1 
ATOM   3265 C  CE  . LYS A 1 438 ? -13.043 -21.340 -0.146 1.00 14.57 ? 415  LYS A CE  1 
ATOM   3266 N  NZ  . LYS A 1 438 ? -11.918 -20.428 -0.237 1.00 14.22 ? 415  LYS A NZ  1 
ATOM   3267 N  N   . ILE A 1 439 ? -13.300 -19.048 5.053  1.00 8.44  ? 416  ILE A N   1 
ATOM   3268 C  CA  . ILE A 1 439 ? -12.553 -17.868 5.478  1.00 7.95  ? 416  ILE A CA  1 
ATOM   3269 C  C   . ILE A 1 439 ? -12.218 -17.012 4.284  1.00 8.35  ? 416  ILE A C   1 
ATOM   3270 O  O   . ILE A 1 439 ? -11.330 -17.358 3.501  1.00 9.50  ? 416  ILE A O   1 
ATOM   3271 C  CB  . ILE A 1 439 ? -11.279 -18.252 6.223  1.00 8.25  ? 416  ILE A CB  1 
ATOM   3272 C  CG1 . ILE A 1 439 ? -11.593 -19.098 7.435  1.00 9.21  ? 416  ILE A CG1 1 
ATOM   3273 C  CG2 . ILE A 1 439 ? -10.529 -16.981 6.609  1.00 8.07  ? 416  ILE A CG2 1 
ATOM   3274 C  CD1 . ILE A 1 439 ? -10.360 -19.687 8.104  1.00 10.44 ? 416  ILE A CD1 1 
ATOM   3275 N  N   . THR A 1 440 ? -12.938 -15.899 4.160  1.00 7.74  ? 417  THR A N   1 
ATOM   3276 C  CA  . THR A 1 440 ? -12.786 -14.930 3.091  1.00 8.05  ? 417  THR A CA  1 
ATOM   3277 C  C   . THR A 1 440 ? -13.013 -13.543 3.674  1.00 7.44  ? 417  THR A C   1 
ATOM   3278 O  O   . THR A 1 440 ? -13.673 -13.382 4.697  1.00 7.53  ? 417  THR A O   1 
ATOM   3279 C  CB  . THR A 1 440 ? -13.793 -15.182 1.959  1.00 8.24  ? 417  THR A CB  1 
ATOM   3280 O  OG1 . THR A 1 440 ? -15.100 -14.814 2.392  1.00 8.55  ? 417  THR A OG1 1 
ATOM   3281 C  CG2 . THR A 1 440 ? -13.772 -16.613 1.462  1.00 8.93  ? 417  THR A CG2 1 
ATOM   3282 N  N   . LEU A 1 441 ? -12.517 -12.534 2.966  1.00 7.66  ? 418  LEU A N   1 
ATOM   3283 C  CA  . LEU A 1 441 ? -12.811 -11.153 3.341  1.00 7.54  ? 418  LEU A CA  1 
ATOM   3284 C  C   . LEU A 1 441 ? -14.310 -10.931 3.409  1.00 7.88  ? 418  LEU A C   1 
ATOM   3285 O  O   . LEU A 1 441 ? -14.827 -10.287 4.318  1.00 7.85  ? 418  LEU A O   1 
ATOM   3286 C  CB  . LEU A 1 441 ? -12.155 -10.152 2.394  1.00 8.54  ? 418  LEU A CB  1 
ATOM   3287 C  CG  . LEU A 1 441 ? -10.635 -10.261 2.282  1.00 9.78  ? 418  LEU A CG  1 
ATOM   3288 C  CD1 . LEU A 1 441 ? -10.117 -9.353  1.207  1.00 11.86 ? 418  LEU A CD1 1 
ATOM   3289 C  CD2 . LEU A 1 441 ? -9.931  -9.981  3.576  1.00 9.59  ? 418  LEU A CD2 1 
ATOM   3290 N  N   . ASP A 1 442 ? -15.009 -11.441 2.393  1.00 7.89  ? 419  ASP A N   1 
ATOM   3291 C  CA  . ASP A 1 442 ? -16.437 -11.162 2.270  1.00 7.99  ? 419  ASP A CA  1 
ATOM   3292 C  C   . ASP A 1 442 ? -17.249 -11.768 3.405  1.00 7.65  ? 419  ASP A C   1 
ATOM   3293 O  O   . ASP A 1 442 ? -18.306 -11.239 3.756  1.00 8.49  ? 419  ASP A O   1 
ATOM   3294 C  CB  . ASP A 1 442 ? -16.939 -11.552 0.885  1.00 8.93  ? 419  ASP A CB  1 
ATOM   3295 C  CG  . ASP A 1 442 ? -16.402 -10.613 -0.182 1.00 9.59  ? 419  ASP A CG  1 
ATOM   3296 O  OD1 . ASP A 1 442 ? -15.907 -9.533  0.113  1.00 9.65  ? 419  ASP A OD1 1 
ATOM   3297 O  OD2 . ASP A 1 442 ? -16.535 -10.957 -1.399 1.00 8.98  ? 419  ASP A OD2 1 
ATOM   3298 N  N   . ALA A 1 443 ? -16.776 -12.854 4.006  1.00 7.83  ? 420  ALA A N   1 
ATOM   3299 C  CA  . ALA A 1 443 ? -17.420 -13.433 5.182  1.00 7.93  ? 420  ALA A CA  1 
ATOM   3300 C  C   . ALA A 1 443 ? -17.474 -12.456 6.354  1.00 7.53  ? 420  ALA A C   1 
ATOM   3301 O  O   . ALA A 1 443 ? -18.336 -12.566 7.217  1.00 8.39  ? 420  ALA A O   1 
ATOM   3302 C  CB  . ALA A 1 443 ? -16.758 -14.676 5.646  1.00 8.14  ? 420  ALA A CB  1 
ATOM   3303 N  N   . PHE A 1 444 ? -16.571 -11.467 6.365  1.00 7.24  ? 421  PHE A N   1 
ATOM   3304 C  CA  . PHE A 1 444 ? -16.414 -10.495 7.452  1.00 7.38  ? 421  PHE A CA  1 
ATOM   3305 C  C   . PHE A 1 444 ? -16.858 -9.102  7.051  1.00 7.53  ? 421  PHE A C   1 
ATOM   3306 O  O   . PHE A 1 444 ? -16.556 -8.155  7.767  1.00 8.62  ? 421  PHE A O   1 
ATOM   3307 C  CB  . PHE A 1 444 ? -14.965 -10.505 7.948  1.00 6.81  ? 421  PHE A CB  1 
ATOM   3308 C  CG  . PHE A 1 444 ? -14.651 -11.736 8.778  1.00 6.46  ? 421  PHE A CG  1 
ATOM   3309 C  CD1 . PHE A 1 444 ? -14.418 -12.967 8.181  1.00 7.24  ? 421  PHE A CD1 1 
ATOM   3310 C  CD2 . PHE A 1 444 ? -14.592 -11.687 10.173 1.00 6.37  ? 421  PHE A CD2 1 
ATOM   3311 C  CE1 . PHE A 1 444 ? -14.164 -14.110 8.917  1.00 7.37  ? 421  PHE A CE1 1 
ATOM   3312 C  CE2 . PHE A 1 444 ? -14.347 -12.834 10.919 1.00 6.81  ? 421  PHE A CE2 1 
ATOM   3313 C  CZ  . PHE A 1 444 ? -14.117 -14.063 10.299 1.00 6.78  ? 421  PHE A CZ  1 
ATOM   3314 N  N   . ARG A 1 445 ? -17.599 -8.967  5.934  1.00 7.15  ? 422  ARG A N   1 
ATOM   3315 C  CA  . ARG A 1 445 ? -18.154 -7.716  5.498  1.00 7.07  ? 422  ARG A CA  1 
ATOM   3316 C  C   . ARG A 1 445 ? -19.661 -7.730  5.728  1.00 7.63  ? 422  ARG A C   1 
ATOM   3317 O  O   . ARG A 1 445 ? -20.277 -8.780  5.913  1.00 9.55  ? 422  ARG A O   1 
ATOM   3318 C  CB  . ARG A 1 445 ? -17.816 -7.443  4.034  1.00 7.18  ? 422  ARG A CB  1 
ATOM   3319 C  CG  . ARG A 1 445 ? -16.335 -7.153  3.897  1.00 6.77  ? 422  ARG A CG  1 
ATOM   3320 C  CD  . ARG A 1 445 ? -15.885 -7.051  2.446  1.00 8.28  ? 422  ARG A CD  1 
ATOM   3321 N  NE  . ARG A 1 445 ? -14.533 -6.500  2.381  1.00 8.01  ? 422  ARG A NE  1 
ATOM   3322 C  CZ  . ARG A 1 445 ? -13.679 -6.622  1.394  1.00 9.15  ? 422  ARG A CZ  1 
ATOM   3323 N  NH1 . ARG A 1 445 ? -13.916 -7.440  0.386  1.00 9.72  ? 422  ARG A NH1 1 
ATOM   3324 N  NH2 . ARG A 1 445 ? -12.539 -5.948  1.466  1.00 9.67  ? 422  ARG A NH2 1 
ATOM   3325 N  N   . LYS A 1 446 ? -20.260 -6.551  5.716  1.00 8.33  ? 423  LYS A N   1 
ATOM   3326 C  CA  . LYS A 1 446 ? -21.678 -6.417  6.049  1.00 10.07 ? 423  LYS A CA  1 
ATOM   3327 C  C   . LYS A 1 446 ? -22.563 -7.056  4.969  1.00 12.17 ? 423  LYS A C   1 
ATOM   3328 O  O   . LYS A 1 446 ? -22.358 -6.887  3.785  1.00 17.11 ? 423  LYS A O   1 
ATOM   3329 C  CB  . LYS A 1 446 ? -21.946 -4.932  6.302  1.00 12.59 ? 423  LYS A CB  1 
ATOM   3330 C  CG  . LYS A 1 446 ? -23.358 -4.621  6.896  1.00 15.09 ? 423  LYS A CG  1 
ATOM   3331 C  CD  . LYS A 1 446 ? -23.484 -3.125  7.214  1.00 18.85 ? 423  LYS A CD  1 
ATOM   3332 C  CE  . LYS A 1 446 ? -24.733 -2.647  7.858  1.00 25.90 ? 423  LYS A CE  1 
ATOM   3333 N  NZ  . LYS A 1 446 ? -24.861 -1.268  7.356  1.00 26.26 ? 423  LYS A NZ  1 
ATOM   3334 N  N   . ASN A 1 447 ? -23.539 -7.806  5.410  1.00 10.73 ? 424  ASN A N   1 
ATOM   3335 C  CA  . ASN A 1 447 ? -24.557 -8.437  4.578  1.00 12.76 ? 424  ASN A CA  1 
ATOM   3336 C  C   . ASN A 1 447 ? -25.719 -7.465  4.502  1.00 13.71 ? 424  ASN A C   1 
ATOM   3337 O  O   . ASN A 1 447 ? -26.367 -7.227  5.537  1.00 15.80 ? 424  ASN A O   1 
ATOM   3338 C  CB  . ASN A 1 447 ? -24.969 -9.743  5.244  1.00 14.56 ? 424  ASN A CB  1 
ATOM   3339 C  CG  . ASN A 1 447 ? -26.147 -10.462 4.634  1.00 15.24 ? 424  ASN A CG  1 
ATOM   3340 O  OD1 . ASN A 1 447 ? -26.741 -10.005 3.667  1.00 13.82 ? 424  ASN A OD1 1 
ATOM   3341 N  ND2 . ASN A 1 447 ? -26.444 -11.616 5.216  1.00 19.29 ? 424  ASN A ND2 1 
ATOM   3342 N  N   . LYS A 1 448 ? -25.928 -6.838  3.341  1.00 13.06 ? 425  LYS A N   1 
ATOM   3343 C  CA  . LYS A 1 448 ? -26.856 -5.716  3.236  1.00 16.39 ? 425  LYS A CA  1 
ATOM   3344 C  C   . LYS A 1 448 ? -28.298 -6.143  3.543  1.00 18.51 ? 425  LYS A C   1 
ATOM   3345 O  O   . LYS A 1 448 ? -29.083 -5.277  3.965  1.00 20.14 ? 425  LYS A O   1 
ATOM   3346 C  CB  . LYS A 1 448 ? -26.711 -5.061  1.865  1.00 19.14 ? 425  LYS A CB  1 
ATOM   3347 C  CG  . LYS A 1 448 ? -27.548 -3.789  1.631  0.70 21.70 ? 425  LYS A CG  1 
ATOM   3348 C  CD  . LYS A 1 448 ? -27.359 -3.217  0.232  0.70 25.56 ? 425  LYS A CD  1 
ATOM   3349 C  CE  . LYS A 1 448 ? -28.300 -2.101  -0.098 0.70 28.71 ? 425  LYS A CE  1 
ATOM   3350 N  NZ  . LYS A 1 448 ? -29.670 -2.618  -0.074 0.70 32.58 ? 425  LYS A NZ  1 
ATOM   3351 N  N   . SER A 1 449 ? -28.683 -7.425  3.392  1.00 17.02 ? 426  SER A N   1 
ATOM   3352 C  CA  . SER A 1 449 ? -30.061 -7.780  3.729  1.00 18.32 ? 426  SER A CA  1 
ATOM   3353 C  C   . SER A 1 449 ? -30.228 -8.157  5.201  1.00 22.20 ? 426  SER A C   1 
ATOM   3354 O  O   . SER A 1 449 ? -31.355 -8.402  5.649  1.00 22.71 ? 426  SER A O   1 
ATOM   3355 C  CB  . SER A 1 449 ? -30.629 -8.849  2.808  1.00 16.32 ? 426  SER A CB  1 
ATOM   3356 O  OG  . SER A 1 449 ? -29.764 -9.964  2.701  1.00 15.30 ? 426  SER A OG  1 
ATOM   3357 N  N   . GLY A 1 450 ? -29.131 -8.159  5.980  1.00 22.15 ? 427  GLY A N   1 
ATOM   3358 C  CA  . GLY A 1 450 ? -29.217 -8.149  7.433  1.00 26.62 ? 427  GLY A CA  1 
ATOM   3359 C  C   . GLY A 1 450 ? -28.734 -9.448  8.047  1.00 31.46 ? 427  GLY A C   1 
ATOM   3360 O  O   . GLY A 1 450 ? -28.583 -9.469  9.297  1.00 36.25 ? 427  GLY A O   1 
ATOM   3361 O  OXT . GLY A 1 450 ? -28.538 -10.416 7.278  1.00 32.90 ? 427  GLY A OXT 1 
HETATM 3362 MG MG  . MG  B 2 .   ? 2.052   11.999  30.182 1.00 18.97 ? 501  MG  A MG  1 
HETATM 3363 MG MG  . MG  C 2 .   ? -4.372  0.452   37.603 1.00 15.68 ? 502  MG  A MG  1 
HETATM 3364 MG MG  . MG  D 2 .   ? -3.492  -24.635 9.202  1.00 26.35 ? 503  MG  A MG  1 
HETATM 3365 NA NA  . NA  E 3 .   ? -13.490 16.897  17.082 1.00 18.40 ? 504  NA  A NA  1 
HETATM 3366 NA NA  . NA  F 3 .   ? 5.671   16.692  21.750 1.00 12.18 ? 505  NA  A NA  1 
HETATM 3367 NA NA  . NA  G 3 .   ? -12.764 3.496   34.710 1.00 23.94 ? 506  NA  A NA  1 
HETATM 3368 C  C1  . EDO H 4 .   ? -10.216 -4.301  28.200 1.00 8.83  ? 507  EDO A C1  1 
HETATM 3369 O  O1  . EDO H 4 .   ? -9.712  -3.279  29.002 1.00 7.66  ? 507  EDO A O1  1 
HETATM 3370 C  C2  . EDO H 4 .   ? -9.353  -5.470  28.175 1.00 10.34 ? 507  EDO A C2  1 
HETATM 3371 O  O2  . EDO H 4 .   ? -7.960  -5.156  27.816 1.00 9.00  ? 507  EDO A O2  1 
HETATM 3372 C  C1  . EDO I 4 .   ? -8.212  -6.011  0.560  1.00 19.96 ? 508  EDO A C1  1 
HETATM 3373 O  O1  . EDO I 4 .   ? -9.544  -5.644  0.850  1.00 18.05 ? 508  EDO A O1  1 
HETATM 3374 C  C2  . EDO I 4 .   ? -8.102  -6.247  -0.917 1.00 24.10 ? 508  EDO A C2  1 
HETATM 3375 O  O2  . EDO I 4 .   ? -8.876  -7.358  -1.381 1.00 27.56 ? 508  EDO A O2  1 
HETATM 3376 C  C1  . EDO J 4 .   ? 16.343  -12.467 15.631 1.00 20.68 ? 509  EDO A C1  1 
HETATM 3377 O  O1  . EDO J 4 .   ? 17.711  -12.761 15.387 1.00 19.83 ? 509  EDO A O1  1 
HETATM 3378 C  C2  . EDO J 4 .   ? 15.470  -13.722 15.611 1.00 19.63 ? 509  EDO A C2  1 
HETATM 3379 O  O2  . EDO J 4 .   ? 15.646  -14.657 14.549 1.00 21.35 ? 509  EDO A O2  1 
HETATM 3380 C  C1  . EDO K 4 .   ? -7.460  33.197  31.483 1.00 24.04 ? 510  EDO A C1  1 
HETATM 3381 O  O1  . EDO K 4 .   ? -6.279  32.774  30.908 1.00 27.58 ? 510  EDO A O1  1 
HETATM 3382 C  C2  . EDO K 4 .   ? -8.160  32.098  32.175 1.00 25.45 ? 510  EDO A C2  1 
HETATM 3383 O  O2  . EDO K 4 .   ? -8.865  32.701  33.226 1.00 24.14 ? 510  EDO A O2  1 
HETATM 3384 C  C1  . EDO L 4 .   ? -17.283 9.037   24.124 1.00 20.06 ? 511  EDO A C1  1 
HETATM 3385 O  O1  . EDO L 4 .   ? -16.140 9.463   24.765 1.00 14.00 ? 511  EDO A O1  1 
HETATM 3386 C  C2  . EDO L 4 .   ? -18.331 10.081  23.995 1.00 20.70 ? 511  EDO A C2  1 
HETATM 3387 O  O2  . EDO L 4 .   ? -17.859 11.204  23.264 1.00 22.68 ? 511  EDO A O2  1 
HETATM 3388 C  C1  . EDO M 4 .   ? -3.983  -14.332 -1.402 0.80 21.50 ? 512  EDO A C1  1 
HETATM 3389 O  O1  . EDO M 4 .   ? -4.734  -14.527 -0.218 0.80 22.80 ? 512  EDO A O1  1 
HETATM 3390 C  C2  . EDO M 4 .   ? -2.582  -14.073 -1.164 0.80 19.52 ? 512  EDO A C2  1 
HETATM 3391 O  O2  . EDO M 4 .   ? -2.214  -12.717 -1.238 0.80 26.61 ? 512  EDO A O2  1 
HETATM 3392 C  C1  . EDO N 4 .   ? 20.966  -7.034  26.331 1.00 21.15 ? 513  EDO A C1  1 
HETATM 3393 O  O1  . EDO N 4 .   ? 21.397  -5.878  25.633 1.00 19.66 ? 513  EDO A O1  1 
HETATM 3394 C  C2  . EDO N 4 .   ? 22.066  -7.833  26.787 1.00 20.51 ? 513  EDO A C2  1 
HETATM 3395 O  O2  . EDO N 4 .   ? 23.064  -8.020  25.811 1.00 20.84 ? 513  EDO A O2  1 
HETATM 3396 C  C1  A EDO O 4 .   ? -17.558 -3.201  26.750 0.70 33.44 ? 514  EDO A C1  1 
HETATM 3397 C  C1  B EDO O 4 .   ? -18.554 -3.268  26.889 0.30 18.22 ? 514  EDO A C1  1 
HETATM 3398 O  O1  A EDO O 4 .   ? -18.410 -3.713  25.759 0.70 28.67 ? 514  EDO A O1  1 
HETATM 3399 O  O1  B EDO O 4 .   ? -17.717 -3.687  27.937 0.30 16.92 ? 514  EDO A O1  1 
HETATM 3400 C  C2  A EDO O 4 .   ? -17.263 -1.836  26.364 0.70 34.19 ? 514  EDO A C2  1 
HETATM 3401 C  C2  B EDO O 4 .   ? -17.882 -2.231  26.075 0.30 16.38 ? 514  EDO A C2  1 
HETATM 3402 O  O2  A EDO O 4 .   ? -18.416 -1.168  25.895 0.70 38.16 ? 514  EDO A O2  1 
HETATM 3403 O  O2  B EDO O 4 .   ? -16.756 -2.723  25.435 0.30 16.54 ? 514  EDO A O2  1 
HETATM 3404 C  C1  . EDO P 4 .   ? -20.322 -7.544  17.004 0.80 8.38  ? 515  EDO A C1  1 
HETATM 3405 O  O1  . EDO P 4 .   ? -19.567 -7.154  15.681 0.80 12.56 ? 515  EDO A O1  1 
HETATM 3406 C  C2  . EDO P 4 .   ? -21.224 -8.794  16.581 0.80 9.69  ? 515  EDO A C2  1 
HETATM 3407 O  O2  . EDO P 4 .   ? -20.566 -9.648  15.488 0.80 11.18 ? 515  EDO A O2  1 
HETATM 3408 N  N   . NH4 Q 5 .   ? 10.525  2.864   11.129 1.00 21.60 ? 516  NH4 A N   1 
HETATM 3409 O  O   . HOH R 6 .   ? 9.064   1.188   11.365 1.00 26.21 ? 601  HOH A O   1 
HETATM 3410 O  O   . HOH R 6 .   ? -4.174  32.311  31.576 1.00 32.52 ? 602  HOH A O   1 
HETATM 3411 O  O   . HOH R 6 .   ? -5.681  35.901  34.119 1.00 35.39 ? 603  HOH A O   1 
HETATM 3412 O  O   . HOH R 6 .   ? 11.580  -1.625  12.502 1.00 27.37 ? 604  HOH A O   1 
HETATM 3413 O  O   . HOH R 6 .   ? -11.126 15.758  39.771 1.00 35.73 ? 605  HOH A O   1 
HETATM 3414 O  O   . HOH R 6 .   ? -20.099 -3.795  23.981 1.00 14.66 ? 606  HOH A O   1 
HETATM 3415 O  O   . HOH R 6 .   ? -12.030 1.052   35.225 1.00 29.65 ? 607  HOH A O   1 
HETATM 3416 O  O   . HOH R 6 .   ? -14.640 -24.751 29.410 1.00 15.32 ? 608  HOH A O   1 
HETATM 3417 O  O   . HOH R 6 .   ? -7.170  27.111  15.228 1.00 40.01 ? 609  HOH A O   1 
HETATM 3418 O  O   . HOH R 6 .   ? -5.603  -16.816 0.123  1.00 29.19 ? 610  HOH A O   1 
HETATM 3419 O  O   . HOH R 6 .   ? 2.348   26.476  0.911  1.00 37.71 ? 611  HOH A O   1 
HETATM 3420 O  O   . HOH R 6 .   ? -21.470 4.401   18.488 1.00 21.40 ? 612  HOH A O   1 
HETATM 3421 O  O   . HOH R 6 .   ? -10.399 23.483  -0.017 1.00 24.07 ? 613  HOH A O   1 
HETATM 3422 O  O   . HOH R 6 .   ? -19.423 11.837  21.427 1.00 24.76 ? 614  HOH A O   1 
HETATM 3423 O  O   . HOH R 6 .   ? -12.209 20.505  41.242 1.00 21.98 ? 615  HOH A O   1 
HETATM 3424 O  O   . HOH R 6 .   ? -16.652 -26.120 21.089 1.00 36.47 ? 616  HOH A O   1 
HETATM 3425 O  O   . HOH R 6 .   ? -0.678  -10.747 -1.411 1.00 28.88 ? 617  HOH A O   1 
HETATM 3426 O  O   . HOH R 6 .   ? -25.271 7.003   8.935  1.00 32.85 ? 618  HOH A O   1 
HETATM 3427 O  O   . HOH R 6 .   ? -20.917 -6.917  13.580 1.00 32.96 ? 619  HOH A O   1 
HETATM 3428 O  O   . HOH R 6 .   ? 0.054   15.100  -2.749 1.00 29.50 ? 620  HOH A O   1 
HETATM 3429 O  O   . HOH R 6 .   ? -7.108  31.265  23.140 1.00 16.30 ? 621  HOH A O   1 
HETATM 3430 O  O   . HOH R 6 .   ? 11.394  12.334  4.234  1.00 29.30 ? 622  HOH A O   1 
HETATM 3431 O  O   . HOH R 6 .   ? -21.476 17.377  16.755 1.00 29.68 ? 623  HOH A O   1 
HETATM 3432 O  O   . HOH R 6 .   ? -6.738  29.235  43.828 1.00 15.57 ? 624  HOH A O   1 
HETATM 3433 O  O   . HOH R 6 .   ? -2.194  -6.972  -1.132 1.00 25.16 ? 625  HOH A O   1 
HETATM 3434 O  O   . HOH R 6 .   ? 1.299   -29.528 11.964 1.00 36.04 ? 626  HOH A O   1 
HETATM 3435 O  O   A HOH R 6 .   ? -24.286 22.382  -0.843 0.70 17.09 ? 627  HOH A O   1 
HETATM 3436 O  O   B HOH R 6 .   ? -23.364 23.364  -0.399 0.30 7.30  ? 627  HOH A O   1 
HETATM 3437 O  O   . HOH R 6 .   ? -20.079 4.404   20.640 1.00 21.37 ? 628  HOH A O   1 
HETATM 3438 O  O   . HOH R 6 .   ? -3.019  -13.139 31.532 1.00 18.38 ? 629  HOH A O   1 
HETATM 3439 O  O   . HOH R 6 .   ? 14.310  1.954   34.996 1.00 35.14 ? 630  HOH A O   1 
HETATM 3440 O  O   . HOH R 6 .   ? 4.075   -0.943  6.768  1.00 20.00 ? 631  HOH A O   1 
HETATM 3441 O  O   . HOH R 6 .   ? 4.731   22.778  19.148 1.00 39.71 ? 632  HOH A O   1 
HETATM 3442 O  O   . HOH R 6 .   ? -15.396 12.704  -2.706 1.00 23.14 ? 633  HOH A O   1 
HETATM 3443 O  O   . HOH R 6 .   ? -7.541  20.431  18.487 1.00 18.22 ? 634  HOH A O   1 
HETATM 3444 O  O   . HOH R 6 .   ? -0.820  29.035  10.705 1.00 42.73 ? 635  HOH A O   1 
HETATM 3445 O  O   . HOH R 6 .   ? -23.060 15.623  8.378  1.00 30.97 ? 636  HOH A O   1 
HETATM 3446 O  O   . HOH R 6 .   ? 18.157  5.750   26.254 1.00 22.99 ? 637  HOH A O   1 
HETATM 3447 O  O   . HOH R 6 .   ? -21.831 28.108  9.589  1.00 30.00 ? 638  HOH A O   1 
HETATM 3448 O  O   . HOH R 6 .   ? 1.914   0.396   5.058  1.00 27.55 ? 639  HOH A O   1 
HETATM 3449 O  O   . HOH R 6 .   ? -1.477  17.181  -3.407 1.00 23.49 ? 640  HOH A O   1 
HETATM 3450 O  O   . HOH R 6 .   ? -20.579 7.872   22.196 1.00 20.33 ? 641  HOH A O   1 
HETATM 3451 O  O   . HOH R 6 .   ? 16.023  -2.631  30.367 1.00 22.89 ? 642  HOH A O   1 
HETATM 3452 O  O   . HOH R 6 .   ? -9.382  6.365   38.137 1.00 17.24 ? 643  HOH A O   1 
HETATM 3453 O  O   . HOH R 6 .   ? -9.643  -5.594  3.441  1.00 10.84 ? 644  HOH A O   1 
HETATM 3454 O  O   . HOH R 6 .   ? 2.537   -6.052  28.981 1.00 12.68 ? 645  HOH A O   1 
HETATM 3455 O  O   . HOH R 6 .   ? -13.336 6.241   36.980 1.00 29.53 ? 646  HOH A O   1 
HETATM 3456 O  O   . HOH R 6 .   ? -20.144 -14.987 17.779 1.00 16.55 ? 647  HOH A O   1 
HETATM 3457 O  O   . HOH R 6 .   ? -27.906 10.891  2.868  1.00 29.87 ? 648  HOH A O   1 
HETATM 3458 O  O   . HOH R 6 .   ? 8.838   -13.461 9.769  1.00 21.93 ? 649  HOH A O   1 
HETATM 3459 O  O   . HOH R 6 .   ? -16.720 22.645  34.228 1.00 27.11 ? 650  HOH A O   1 
HETATM 3460 O  O   . HOH R 6 .   ? -16.226 4.035   3.348  1.00 15.73 ? 651  HOH A O   1 
HETATM 3461 O  O   . HOH R 6 .   ? -16.949 -19.296 14.885 1.00 9.18  ? 652  HOH A O   1 
HETATM 3462 O  O   . HOH R 6 .   ? -33.730 -8.052  4.613  1.00 36.42 ? 653  HOH A O   1 
HETATM 3463 O  O   . HOH R 6 .   ? -2.273  27.905  31.918 1.00 19.49 ? 654  HOH A O   1 
HETATM 3464 O  O   . HOH R 6 .   ? 2.654   12.399  26.742 1.00 13.27 ? 655  HOH A O   1 
HETATM 3465 O  O   . HOH R 6 .   ? -21.510 13.825  18.617 1.00 32.25 ? 656  HOH A O   1 
HETATM 3466 O  O   . HOH R 6 .   ? 12.235  4.557   10.098 1.00 19.98 ? 657  HOH A O   1 
HETATM 3467 O  O   . HOH R 6 .   ? -19.135 -22.290 17.227 1.00 38.33 ? 658  HOH A O   1 
HETATM 3468 O  O   . HOH R 6 .   ? -10.407 -3.456  -0.301 1.00 27.19 ? 659  HOH A O   1 
HETATM 3469 O  O   . HOH R 6 .   ? -14.512 26.554  40.609 1.00 28.07 ? 660  HOH A O   1 
HETATM 3470 O  O   . HOH R 6 .   ? 15.947  -20.119 12.514 1.00 35.56 ? 661  HOH A O   1 
HETATM 3471 O  O   . HOH R 6 .   ? 9.807   8.813   0.766  1.00 15.23 ? 662  HOH A O   1 
HETATM 3472 O  O   . HOH R 6 .   ? 16.784  -3.429  20.780 1.00 9.92  ? 663  HOH A O   1 
HETATM 3473 O  O   . HOH R 6 .   ? -22.460 -18.311 12.923 1.00 33.48 ? 664  HOH A O   1 
HETATM 3474 O  O   . HOH R 6 .   ? -10.629 8.348   1.594  1.00 19.03 ? 665  HOH A O   1 
HETATM 3475 O  O   . HOH R 6 .   ? -4.377  12.864  43.934 1.00 17.21 ? 666  HOH A O   1 
HETATM 3476 O  O   . HOH R 6 .   ? -21.836 3.814   5.417  1.00 18.71 ? 667  HOH A O   1 
HETATM 3477 O  O   . HOH R 6 .   ? 5.137   -24.616 11.592 1.00 29.48 ? 668  HOH A O   1 
HETATM 3478 O  O   . HOH R 6 .   ? 1.632   -20.001 28.013 1.00 10.02 ? 669  HOH A O   1 
HETATM 3479 O  O   . HOH R 6 .   ? 9.304   -0.502  13.402 1.00 11.59 ? 670  HOH A O   1 
HETATM 3480 O  O   . HOH R 6 .   ? -8.813  -29.128 13.331 1.00 25.39 ? 671  HOH A O   1 
HETATM 3481 O  O   . HOH R 6 .   ? 0.790   5.690   34.368 1.00 8.16  ? 672  HOH A O   1 
HETATM 3482 O  O   . HOH R 6 .   ? -7.777  0.361   1.258  1.00 16.99 ? 673  HOH A O   1 
HETATM 3483 O  O   . HOH R 6 .   ? -19.304 14.805  -3.549 1.00 32.35 ? 674  HOH A O   1 
HETATM 3484 O  O   . HOH R 6 .   ? -9.094  26.526  -0.547 1.00 31.45 ? 675  HOH A O   1 
HETATM 3485 O  O   . HOH R 6 .   ? -23.867 -8.331  8.337  1.00 20.40 ? 676  HOH A O   1 
HETATM 3486 O  O   . HOH R 6 .   ? -5.012  -2.454  35.488 1.00 18.52 ? 677  HOH A O   1 
HETATM 3487 O  O   . HOH R 6 .   ? 10.103  -3.386  13.521 1.00 22.79 ? 678  HOH A O   1 
HETATM 3488 O  O   . HOH R 6 .   ? 8.348   12.926  40.995 1.00 15.00 ? 679  HOH A O   1 
HETATM 3489 O  O   . HOH R 6 .   ? -3.294  -29.626 22.833 1.00 20.69 ? 680  HOH A O   1 
HETATM 3490 O  O   . HOH R 6 .   ? -30.748 12.792  1.758  1.00 19.82 ? 681  HOH A O   1 
HETATM 3491 O  O   . HOH R 6 .   ? -23.738 8.736   11.950 1.00 31.52 ? 682  HOH A O   1 
HETATM 3492 O  O   . HOH R 6 .   ? -20.745 5.434   3.531  1.00 24.52 ? 683  HOH A O   1 
HETATM 3493 O  O   . HOH R 6 .   ? 7.449   -4.526  10.001 1.00 22.71 ? 684  HOH A O   1 
HETATM 3494 O  O   . HOH R 6 .   ? 5.444   7.890   41.769 1.00 22.41 ? 685  HOH A O   1 
HETATM 3495 O  O   . HOH R 6 .   ? 18.233  -10.375 14.327 1.00 24.57 ? 686  HOH A O   1 
HETATM 3496 O  O   . HOH R 6 .   ? -23.969 1.854   10.473 1.00 14.61 ? 687  HOH A O   1 
HETATM 3497 O  O   . HOH R 6 .   ? 15.696  -17.716 18.206 1.00 17.89 ? 688  HOH A O   1 
HETATM 3498 O  O   . HOH R 6 .   ? -18.152 17.354  22.680 1.00 25.13 ? 689  HOH A O   1 
HETATM 3499 O  O   . HOH R 6 .   ? 1.671   22.991  7.217  1.00 16.55 ? 690  HOH A O   1 
HETATM 3500 O  O   . HOH R 6 .   ? 17.659  -0.404  11.537 1.00 30.82 ? 691  HOH A O   1 
HETATM 3501 O  O   . HOH R 6 .   ? -3.540  34.656  37.346 1.00 30.92 ? 692  HOH A O   1 
HETATM 3502 O  O   . HOH R 6 .   ? 12.456  6.930   11.549 1.00 16.07 ? 693  HOH A O   1 
HETATM 3503 O  O   . HOH R 6 .   ? -24.481 29.536  10.781 1.00 30.00 ? 694  HOH A O   1 
HETATM 3504 O  O   . HOH R 6 .   ? 10.515  16.535  23.015 1.00 20.70 ? 695  HOH A O   1 
HETATM 3505 O  O   . HOH R 6 .   ? -0.812  1.968   27.446 1.00 5.64  ? 696  HOH A O   1 
HETATM 3506 O  O   . HOH R 6 .   ? -11.175 -1.615  30.495 1.00 9.03  ? 697  HOH A O   1 
HETATM 3507 O  O   . HOH R 6 .   ? -5.873  -18.102 33.353 1.00 19.38 ? 698  HOH A O   1 
HETATM 3508 O  O   . HOH R 6 .   ? 14.568  4.957   33.658 1.00 17.63 ? 699  HOH A O   1 
HETATM 3509 O  O   . HOH R 6 .   ? -12.875 -30.230 17.125 1.00 20.71 ? 700  HOH A O   1 
HETATM 3510 O  O   . HOH R 6 .   ? 15.318  -13.700 12.068 1.00 35.23 ? 701  HOH A O   1 
HETATM 3511 O  O   . HOH R 6 .   ? -24.520 11.871  -2.973 1.00 17.87 ? 702  HOH A O   1 
HETATM 3512 O  O   . HOH R 6 .   ? -13.724 19.541  16.069 1.00 15.44 ? 703  HOH A O   1 
HETATM 3513 O  O   . HOH R 6 .   ? -6.428  -25.792 3.072  1.00 17.65 ? 704  HOH A O   1 
HETATM 3514 O  O   . HOH R 6 .   ? 14.008  -19.586 31.479 1.00 19.84 ? 705  HOH A O   1 
HETATM 3515 O  O   . HOH R 6 .   ? -13.049 25.236  -0.134 1.00 22.14 ? 706  HOH A O   1 
HETATM 3516 O  O   . HOH R 6 .   ? -19.790 -10.497 8.135  1.00 19.34 ? 707  HOH A O   1 
HETATM 3517 O  O   . HOH R 6 .   ? 0.456   13.167  22.826 1.00 7.95  ? 708  HOH A O   1 
HETATM 3518 O  O   . HOH R 6 .   ? 6.776   -13.656 31.533 1.00 13.36 ? 709  HOH A O   1 
HETATM 3519 O  O   . HOH R 6 .   ? 19.466  -1.535  26.714 1.00 24.72 ? 710  HOH A O   1 
HETATM 3520 O  O   . HOH R 6 .   ? -11.053 24.483  38.009 1.00 10.28 ? 711  HOH A O   1 
HETATM 3521 O  O   . HOH R 6 .   ? -18.658 21.177  18.062 1.00 35.90 ? 712  HOH A O   1 
HETATM 3522 O  O   . HOH R 6 .   ? 12.397  11.483  32.859 1.00 14.57 ? 713  HOH A O   1 
HETATM 3523 O  O   . HOH R 6 .   ? 13.360  -9.878  29.411 1.00 9.99  ? 714  HOH A O   1 
HETATM 3524 O  O   . HOH R 6 .   ? -16.198 -23.886 -0.451 1.00 25.19 ? 715  HOH A O   1 
HETATM 3525 O  O   . HOH R 6 .   ? 3.728   -20.184 17.989 1.00 8.64  ? 716  HOH A O   1 
HETATM 3526 O  O   . HOH R 6 .   ? -13.163 19.651  25.845 1.00 14.57 ? 717  HOH A O   1 
HETATM 3527 O  O   . HOH R 6 .   ? -27.664 26.341  4.183  1.00 27.00 ? 718  HOH A O   1 
HETATM 3528 O  O   . HOH R 6 .   ? 5.196   5.904   0.943  1.00 21.68 ? 719  HOH A O   1 
HETATM 3529 O  O   . HOH R 6 .   ? -0.697  11.499  30.547 1.00 6.57  ? 720  HOH A O   1 
HETATM 3530 O  O   . HOH R 6 .   ? 1.753   9.444   8.790  1.00 6.95  ? 721  HOH A O   1 
HETATM 3531 O  O   . HOH R 6 .   ? 22.151  -14.775 25.644 1.00 8.85  ? 722  HOH A O   1 
HETATM 3532 O  O   . HOH R 6 .   ? 8.350   -18.395 14.440 1.00 8.36  ? 723  HOH A O   1 
HETATM 3533 O  O   . HOH R 6 .   ? -14.748 -28.034 31.243 1.00 10.11 ? 724  HOH A O   1 
HETATM 3534 O  O   A HOH R 6 .   ? -21.659 17.720  7.652  0.80 13.81 ? 725  HOH A O   1 
HETATM 3535 O  O   B HOH R 6 .   ? -23.066 18.114  7.994  0.20 7.97  ? 725  HOH A O   1 
HETATM 3536 O  O   . HOH R 6 .   ? 16.833  -12.924 28.960 1.00 25.99 ? 726  HOH A O   1 
HETATM 3537 O  O   . HOH R 6 .   ? 13.847  -22.451 27.420 1.00 27.79 ? 727  HOH A O   1 
HETATM 3538 O  O   . HOH R 6 .   ? -13.336 -28.829 5.378  1.00 40.58 ? 728  HOH A O   1 
HETATM 3539 O  O   . HOH R 6 .   ? -1.931  22.544  13.932 1.00 16.40 ? 729  HOH A O   1 
HETATM 3540 O  O   A HOH R 6 .   ? -2.734  7.362   42.734 0.80 21.26 ? 730  HOH A O   1 
HETATM 3541 O  O   B HOH R 6 .   ? -3.682  5.867   43.401 0.20 5.95  ? 730  HOH A O   1 
HETATM 3542 O  O   . HOH R 6 .   ? -3.238  -20.929 27.521 1.00 8.33  ? 731  HOH A O   1 
HETATM 3543 O  O   . HOH R 6 .   ? -5.215  -22.042 31.137 1.00 12.80 ? 732  HOH A O   1 
HETATM 3544 O  O   . HOH R 6 .   ? -11.583 -7.178  -1.389 1.00 21.80 ? 733  HOH A O   1 
HETATM 3545 O  O   . HOH R 6 .   ? -14.153 -29.539 21.328 1.00 27.08 ? 734  HOH A O   1 
HETATM 3546 O  O   . HOH R 6 .   ? -16.514 25.081  2.507  1.00 15.33 ? 735  HOH A O   1 
HETATM 3547 O  O   . HOH R 6 .   ? -23.724 19.052  12.033 1.00 28.86 ? 736  HOH A O   1 
HETATM 3548 O  O   . HOH R 6 .   ? 1.579   -18.182 6.339  1.00 16.96 ? 737  HOH A O   1 
HETATM 3549 O  O   . HOH R 6 .   ? 2.160   -8.531  17.668 1.00 6.07  ? 738  HOH A O   1 
HETATM 3550 O  O   . HOH R 6 .   ? -18.764 0.301   22.216 1.00 15.46 ? 739  HOH A O   1 
HETATM 3551 O  O   . HOH R 6 .   ? -18.204 13.535  34.132 1.00 25.27 ? 740  HOH A O   1 
HETATM 3552 O  O   . HOH R 6 .   ? 16.284  8.520   20.342 1.00 16.14 ? 741  HOH A O   1 
HETATM 3553 O  O   . HOH R 6 .   ? 19.199  -0.394  29.943 1.00 21.62 ? 742  HOH A O   1 
HETATM 3554 O  O   . HOH R 6 .   ? -0.998  21.585  28.014 1.00 10.75 ? 743  HOH A O   1 
HETATM 3555 O  O   . HOH R 6 .   ? 9.195   -16.835 7.032  1.00 21.46 ? 744  HOH A O   1 
HETATM 3556 O  O   . HOH R 6 .   ? -10.983 -31.926 20.910 1.00 40.98 ? 745  HOH A O   1 
HETATM 3557 O  O   . HOH R 6 .   ? 12.947  10.455  35.409 1.00 18.19 ? 746  HOH A O   1 
HETATM 3558 O  O   . HOH R 6 .   ? -3.522  -23.648 27.273 1.00 9.45  ? 747  HOH A O   1 
HETATM 3559 O  O   . HOH R 6 .   ? 15.466  -20.117 19.629 1.00 19.44 ? 748  HOH A O   1 
HETATM 3560 O  O   . HOH R 6 .   ? 5.663   14.939  43.149 1.00 19.04 ? 749  HOH A O   1 
HETATM 3561 O  O   . HOH R 6 .   ? -8.170  -9.942  -1.857 1.00 33.15 ? 750  HOH A O   1 
HETATM 3562 O  O   . HOH R 6 .   ? -14.374 22.767  32.692 1.00 16.17 ? 751  HOH A O   1 
HETATM 3563 O  O   . HOH R 6 .   ? -19.856 6.704   24.966 1.00 28.68 ? 752  HOH A O   1 
HETATM 3564 O  O   . HOH R 6 .   ? -2.549  25.410  39.471 1.00 19.49 ? 753  HOH A O   1 
HETATM 3565 O  O   . HOH R 6 .   ? -14.341 24.647  4.176  1.00 16.84 ? 754  HOH A O   1 
HETATM 3566 O  O   . HOH R 6 .   ? -6.599  31.265  42.061 1.00 15.96 ? 755  HOH A O   1 
HETATM 3567 O  O   . HOH R 6 .   ? 6.874   16.709  4.086  1.00 23.14 ? 756  HOH A O   1 
HETATM 3568 O  O   . HOH R 6 .   ? -2.205  -18.114 10.664 1.00 7.27  ? 757  HOH A O   1 
HETATM 3569 O  O   . HOH R 6 .   ? 5.481   7.082   19.901 1.00 7.30  ? 758  HOH A O   1 
HETATM 3570 O  O   . HOH R 6 .   ? 0.404   15.972  23.113 1.00 6.93  ? 759  HOH A O   1 
HETATM 3571 O  O   . HOH R 6 .   ? -11.525 18.281  18.650 1.00 20.24 ? 760  HOH A O   1 
HETATM 3572 O  O   . HOH R 6 .   ? -13.892 13.865  -0.656 1.00 13.11 ? 761  HOH A O   1 
HETATM 3573 O  O   . HOH R 6 .   ? -8.133  26.867  11.333 1.00 20.48 ? 762  HOH A O   1 
HETATM 3574 O  O   . HOH R 6 .   ? -1.168  23.861  38.040 1.00 18.34 ? 763  HOH A O   1 
HETATM 3575 O  O   . HOH R 6 .   ? -2.425  21.385  19.812 1.00 2.03  ? 764  HOH A O   1 
HETATM 3576 O  O   . HOH R 6 .   ? -8.327  23.868  16.978 1.00 25.08 ? 765  HOH A O   1 
HETATM 3577 O  O   . HOH R 6 .   ? -1.964  27.683  28.982 1.00 23.33 ? 766  HOH A O   1 
HETATM 3578 O  O   . HOH R 6 .   ? 10.101  -9.425  15.866 1.00 7.86  ? 767  HOH A O   1 
HETATM 3579 O  O   . HOH R 6 .   ? 4.988   -26.923 20.971 1.00 21.85 ? 768  HOH A O   1 
HETATM 3580 O  O   . HOH R 6 .   ? 1.342   -13.188 30.372 1.00 20.81 ? 769  HOH A O   1 
HETATM 3581 O  O   . HOH R 6 .   ? 10.936  17.835  37.019 1.00 25.93 ? 770  HOH A O   1 
HETATM 3582 O  O   . HOH R 6 .   ? -9.718  18.209  22.294 1.00 10.78 ? 771  HOH A O   1 
HETATM 3583 O  O   . HOH R 6 .   ? 9.682   -1.884  31.897 1.00 9.10  ? 772  HOH A O   1 
HETATM 3584 O  O   . HOH R 6 .   ? 3.121   -23.163 15.115 1.00 10.57 ? 773  HOH A O   1 
HETATM 3585 O  O   . HOH R 6 .   ? -29.357 16.744  2.070  1.00 21.68 ? 774  HOH A O   1 
HETATM 3586 O  O   . HOH R 6 .   ? -1.320  3.124   25.079 1.00 5.97  ? 775  HOH A O   1 
HETATM 3587 O  O   . HOH R 6 .   ? -7.413  -13.690 35.267 1.00 24.11 ? 776  HOH A O   1 
HETATM 3588 O  O   . HOH R 6 .   ? 1.438   -1.079  35.044 1.00 14.61 ? 777  HOH A O   1 
HETATM 3589 O  O   . HOH R 6 .   ? -21.043 8.384   0.324  1.00 25.59 ? 778  HOH A O   1 
HETATM 3590 O  O   . HOH R 6 .   ? 4.173   19.865  6.061  1.00 21.30 ? 779  HOH A O   1 
HETATM 3591 O  O   . HOH R 6 .   ? 16.723  4.613   22.150 1.00 10.13 ? 780  HOH A O   1 
HETATM 3592 O  O   . HOH R 6 .   ? 1.623   -13.696 6.076  1.00 13.60 ? 781  HOH A O   1 
HETATM 3593 O  O   . HOH R 6 .   ? 13.542  12.392  24.306 1.00 23.88 ? 782  HOH A O   1 
HETATM 3594 O  O   . HOH R 6 .   ? 3.451   0.200   38.918 1.00 12.35 ? 783  HOH A O   1 
HETATM 3595 O  O   . HOH R 6 .   ? -15.965 -4.058  6.375  1.00 7.89  ? 784  HOH A O   1 
HETATM 3596 O  O   . HOH R 6 .   ? -18.868 -25.361 4.415  1.00 34.25 ? 785  HOH A O   1 
HETATM 3597 O  O   . HOH R 6 .   ? 2.548   21.065  8.829  1.00 31.07 ? 786  HOH A O   1 
HETATM 3598 O  O   . HOH R 6 .   ? 3.371   4.202   -2.297 1.00 30.14 ? 787  HOH A O   1 
HETATM 3599 O  O   . HOH R 6 .   ? 3.675   17.041  40.725 1.00 17.01 ? 788  HOH A O   1 
HETATM 3600 O  O   . HOH R 6 .   ? 5.614   -1.355  28.146 1.00 6.97  ? 789  HOH A O   1 
HETATM 3601 O  O   . HOH R 6 .   ? 4.741   15.958  32.906 1.00 10.78 ? 790  HOH A O   1 
HETATM 3602 O  O   . HOH R 6 .   ? 0.895   4.783   24.904 1.00 6.65  ? 791  HOH A O   1 
HETATM 3603 O  O   . HOH R 6 .   ? -20.386 -9.793  2.704  1.00 18.10 ? 792  HOH A O   1 
HETATM 3604 O  O   . HOH R 6 .   ? 10.588  11.318  -2.079 1.00 11.92 ? 793  HOH A O   1 
HETATM 3605 O  O   . HOH R 6 .   ? -17.843 13.183  25.164 1.00 20.11 ? 794  HOH A O   1 
HETATM 3606 O  O   . HOH R 6 .   ? -12.678 -31.160 26.881 1.00 14.00 ? 795  HOH A O   1 
HETATM 3607 O  O   . HOH R 6 .   ? 0.426   -25.548 25.625 1.00 13.32 ? 796  HOH A O   1 
HETATM 3608 O  O   . HOH R 6 .   ? -8.923  4.172   3.563  1.00 12.19 ? 797  HOH A O   1 
HETATM 3609 O  O   . HOH R 6 .   ? -8.839  35.402  35.064 1.00 29.87 ? 798  HOH A O   1 
HETATM 3610 O  O   . HOH R 6 .   ? 12.739  18.542  28.113 1.00 21.68 ? 799  HOH A O   1 
HETATM 3611 O  O   . HOH R 6 .   ? 9.325   19.926  30.343 1.00 16.25 ? 800  HOH A O   1 
HETATM 3612 O  O   . HOH R 6 .   ? -11.284 -2.314  1.965  1.00 19.87 ? 801  HOH A O   1 
HETATM 3613 O  O   . HOH R 6 .   ? -7.651  -32.653 8.544  1.00 33.71 ? 802  HOH A O   1 
HETATM 3614 O  O   . HOH R 6 .   ? -24.288 21.108  8.615  1.00 25.88 ? 803  HOH A O   1 
HETATM 3615 O  O   . HOH R 6 .   ? -16.916 -16.864 2.889  1.00 14.94 ? 804  HOH A O   1 
HETATM 3616 O  O   . HOH R 6 .   ? -13.733 25.558  12.177 1.00 17.07 ? 805  HOH A O   1 
HETATM 3617 O  O   . HOH R 6 .   ? -19.304 10.072  27.518 1.00 24.16 ? 806  HOH A O   1 
HETATM 3618 O  O   . HOH R 6 .   ? -9.440  14.793  34.148 1.00 7.50  ? 807  HOH A O   1 
HETATM 3619 O  O   . HOH R 6 .   ? 2.196   -4.970  5.896  1.00 22.76 ? 808  HOH A O   1 
HETATM 3620 O  O   . HOH R 6 .   ? -2.781  20.819  15.800 1.00 13.54 ? 809  HOH A O   1 
HETATM 3621 O  O   . HOH R 6 .   ? 20.530  3.956   22.231 1.00 24.42 ? 810  HOH A O   1 
HETATM 3622 O  O   . HOH R 6 .   ? 3.307   -15.816 29.560 1.00 18.81 ? 811  HOH A O   1 
HETATM 3623 O  O   . HOH R 6 .   ? 2.820   -29.376 17.118 1.00 22.41 ? 812  HOH A O   1 
HETATM 3624 O  O   . HOH R 6 .   ? -0.177  24.115  27.322 1.00 16.45 ? 813  HOH A O   1 
HETATM 3625 O  O   . HOH R 6 .   ? -5.954  11.125  25.305 1.00 6.57  ? 814  HOH A O   1 
HETATM 3626 O  O   . HOH R 6 .   ? 2.522   19.755  17.586 1.00 24.13 ? 815  HOH A O   1 
HETATM 3627 O  O   . HOH R 6 .   ? -22.912 -9.062  14.161 1.00 19.39 ? 816  HOH A O   1 
HETATM 3628 O  O   . HOH R 6 .   ? -9.220  10.364  37.489 1.00 9.57  ? 817  HOH A O   1 
HETATM 3629 O  O   . HOH R 6 .   ? -16.163 12.968  35.708 1.00 23.45 ? 818  HOH A O   1 
HETATM 3630 O  O   . HOH R 6 .   ? -13.465 -25.476 14.280 1.00 12.71 ? 819  HOH A O   1 
HETATM 3631 O  O   . HOH R 6 .   ? -14.389 21.922  27.074 1.00 19.22 ? 820  HOH A O   1 
HETATM 3632 O  O   . HOH R 6 .   ? -5.353  24.747  0.383  1.00 19.01 ? 821  HOH A O   1 
HETATM 3633 O  O   . HOH R 6 .   ? 20.385  1.387   25.622 1.00 35.05 ? 822  HOH A O   1 
HETATM 3634 O  O   . HOH R 6 .   ? -5.979  -29.517 14.333 1.00 38.95 ? 823  HOH A O   1 
HETATM 3635 O  O   . HOH R 6 .   ? -2.204  16.152  22.308 1.00 6.63  ? 824  HOH A O   1 
HETATM 3636 O  O   . HOH R 6 .   ? -0.989  8.564   2.176  1.00 15.02 ? 825  HOH A O   1 
HETATM 3637 O  O   . HOH R 6 .   ? -9.768  -16.197 1.535  1.00 15.91 ? 826  HOH A O   1 
HETATM 3638 O  O   . HOH R 6 .   ? -1.104  24.284  10.974 1.00 24.74 ? 827  HOH A O   1 
HETATM 3639 O  O   . HOH R 6 .   ? 11.948  13.075  12.962 1.00 24.82 ? 828  HOH A O   1 
HETATM 3640 O  O   . HOH R 6 .   ? 5.416   -16.107 4.795  1.00 35.38 ? 829  HOH A O   1 
HETATM 3641 O  O   . HOH R 6 .   ? 13.937  10.809  22.108 1.00 22.87 ? 830  HOH A O   1 
HETATM 3642 O  O   . HOH R 6 .   ? -18.836 -27.461 13.401 1.00 37.22 ? 831  HOH A O   1 
HETATM 3643 O  O   . HOH R 6 .   ? -0.549  -20.515 4.364  1.00 12.34 ? 832  HOH A O   1 
HETATM 3644 O  O   . HOH R 6 .   ? -19.572 14.427  28.995 1.00 23.20 ? 833  HOH A O   1 
HETATM 3645 O  O   . HOH R 6 .   ? 6.830   -21.641 26.649 1.00 22.50 ? 834  HOH A O   1 
HETATM 3646 O  O   . HOH R 6 .   ? 6.762   -14.859 26.619 1.00 8.65  ? 835  HOH A O   1 
HETATM 3647 O  O   . HOH R 6 .   ? -7.661  -28.126 24.250 1.00 9.40  ? 836  HOH A O   1 
HETATM 3648 O  O   . HOH R 6 .   ? 12.852  -12.349 13.811 1.00 21.08 ? 837  HOH A O   1 
HETATM 3649 O  O   . HOH R 6 .   ? -15.184 27.533  7.953  1.00 22.31 ? 838  HOH A O   1 
HETATM 3650 O  O   . HOH R 6 .   ? 9.911   -7.781  25.339 1.00 6.52  ? 839  HOH A O   1 
HETATM 3651 O  O   . HOH R 6 .   ? 12.571  -6.756  25.500 1.00 7.52  ? 840  HOH A O   1 
HETATM 3652 O  O   . HOH R 6 .   ? -17.167 -3.991  22.247 1.00 8.77  ? 841  HOH A O   1 
HETATM 3653 O  O   . HOH R 6 .   ? 7.837   15.487  19.162 1.00 17.56 ? 842  HOH A O   1 
HETATM 3654 O  O   . HOH R 6 .   ? -3.521  29.820  33.627 1.00 17.04 ? 843  HOH A O   1 
HETATM 3655 O  O   . HOH R 6 .   ? -15.269 -5.770  8.382  1.00 8.58  ? 844  HOH A O   1 
HETATM 3656 O  O   . HOH R 6 .   ? -9.529  -14.647 28.111 1.00 9.35  ? 845  HOH A O   1 
HETATM 3657 O  O   . HOH R 6 .   ? -15.526 -3.159  2.224  1.00 22.53 ? 846  HOH A O   1 
HETATM 3658 O  O   . HOH R 6 .   ? 7.750   -21.547 19.999 1.00 9.17  ? 847  HOH A O   1 
HETATM 3659 O  O   . HOH R 6 .   ? 7.467   6.240   -0.647 1.00 16.79 ? 848  HOH A O   1 
HETATM 3660 O  O   . HOH R 6 .   ? -6.671  -4.310  30.137 1.00 10.23 ? 849  HOH A O   1 
HETATM 3661 O  O   . HOH R 6 .   ? -8.062  10.433  43.977 1.00 22.21 ? 850  HOH A O   1 
HETATM 3662 O  O   . HOH R 6 .   ? 11.455  0.874   25.515 1.00 7.05  ? 851  HOH A O   1 
HETATM 3663 O  O   . HOH R 6 .   ? 5.624   -7.959  6.315  1.00 19.18 ? 852  HOH A O   1 
HETATM 3664 O  O   . HOH R 6 .   ? 5.833   15.162  10.108 1.00 11.88 ? 853  HOH A O   1 
HETATM 3665 O  O   . HOH R 6 .   ? -29.820 -11.525 5.066  1.00 23.07 ? 854  HOH A O   1 
HETATM 3666 O  O   . HOH R 6 .   ? 13.801  -6.229  22.980 1.00 7.44  ? 855  HOH A O   1 
HETATM 3667 O  O   . HOH R 6 .   ? -16.325 -28.987 18.974 1.00 36.46 ? 856  HOH A O   1 
HETATM 3668 O  O   . HOH R 6 .   ? 0.732   21.676  10.074 1.00 22.09 ? 857  HOH A O   1 
HETATM 3669 O  O   . HOH R 6 .   ? -20.058 -14.706 7.714  1.00 13.43 ? 858  HOH A O   1 
HETATM 3670 O  O   . HOH R 6 .   ? -24.097 0.294   5.172  1.00 35.02 ? 859  HOH A O   1 
HETATM 3671 O  O   . HOH R 6 .   ? -0.069  16.267  40.573 1.00 21.03 ? 860  HOH A O   1 
HETATM 3672 O  O   . HOH R 6 .   ? 9.492   -0.711  24.415 1.00 7.03  ? 861  HOH A O   1 
HETATM 3673 O  O   . HOH R 6 .   ? -23.070 -1.681  11.183 1.00 14.14 ? 862  HOH A O   1 
HETATM 3674 O  O   . HOH R 6 .   ? -2.920  20.000  2.802  1.00 13.76 ? 863  HOH A O   1 
HETATM 3675 O  O   . HOH R 6 .   ? 3.127   -2.795  28.264 1.00 8.54  ? 864  HOH A O   1 
HETATM 3676 O  O   . HOH R 6 .   ? 8.502   7.517   41.023 1.00 18.93 ? 865  HOH A O   1 
HETATM 3677 O  O   . HOH R 6 .   ? -18.293 15.900  32.555 1.00 19.64 ? 866  HOH A O   1 
HETATM 3678 O  O   . HOH R 6 .   ? 7.970   8.474   2.824  1.00 17.16 ? 867  HOH A O   1 
HETATM 3679 O  O   . HOH R 6 .   ? -6.866  28.293  2.065  1.00 32.49 ? 868  HOH A O   1 
HETATM 3680 O  O   . HOH R 6 .   ? -11.636 33.021  33.460 1.00 10.19 ? 869  HOH A O   1 
HETATM 3681 O  O   . HOH R 6 .   ? -23.485 -6.768  12.612 1.00 37.60 ? 870  HOH A O   1 
HETATM 3682 O  O   . HOH R 6 .   ? 5.739   19.146  38.130 1.00 23.35 ? 871  HOH A O   1 
HETATM 3683 O  O   . HOH R 6 .   ? -11.568 23.206  16.902 1.00 29.66 ? 872  HOH A O   1 
HETATM 3684 O  O   . HOH R 6 .   ? -10.227 19.315  34.365 1.00 6.84  ? 873  HOH A O   1 
HETATM 3685 O  O   . HOH R 6 .   ? -3.525  31.603  40.450 1.00 30.36 ? 874  HOH A O   1 
HETATM 3686 O  O   . HOH R 6 .   ? -9.599  31.191  36.839 1.00 16.29 ? 875  HOH A O   1 
HETATM 3687 O  O   . HOH R 6 .   ? -10.535 11.273  27.241 1.00 6.88  ? 876  HOH A O   1 
HETATM 3688 O  O   . HOH R 6 .   ? 14.635  7.068   29.590 1.00 19.44 ? 877  HOH A O   1 
HETATM 3689 O  O   . HOH R 6 .   ? -3.511  30.378  24.755 1.00 26.74 ? 878  HOH A O   1 
HETATM 3690 O  O   . HOH R 6 .   ? 1.364   -8.670  30.184 1.00 29.40 ? 879  HOH A O   1 
HETATM 3691 O  O   . HOH R 6 .   ? -24.289 -23.056 9.609  1.00 40.85 ? 880  HOH A O   1 
HETATM 3692 O  O   . HOH R 6 .   ? 8.303   3.493   12.960 1.00 8.34  ? 881  HOH A O   1 
HETATM 3693 O  O   . HOH R 6 .   ? -10.462 8.697   39.397 1.00 18.14 ? 882  HOH A O   1 
HETATM 3694 O  O   . HOH R 6 .   ? -18.667 -22.463 2.899  1.00 29.82 ? 883  HOH A O   1 
HETATM 3695 O  O   A HOH R 6 .   ? 16.910  3.193   15.372 0.70 13.62 ? 884  HOH A O   1 
HETATM 3696 O  O   B HOH R 6 .   ? 15.804  1.932   14.729 0.30 12.70 ? 884  HOH A O   1 
HETATM 3697 O  O   . HOH R 6 .   ? 5.618   4.970   42.341 1.00 18.04 ? 885  HOH A O   1 
HETATM 3698 O  O   . HOH R 6 .   ? -15.363 -26.559 15.940 1.00 17.11 ? 886  HOH A O   1 
HETATM 3699 O  O   . HOH R 6 .   ? -16.559 21.509  37.016 1.00 30.16 ? 887  HOH A O   1 
HETATM 3700 O  O   . HOH R 6 .   ? -2.810  -13.132 9.784  1.00 7.65  ? 888  HOH A O   1 
HETATM 3701 O  O   . HOH R 6 .   ? -10.531 10.633  -0.184 1.00 30.68 ? 889  HOH A O   1 
HETATM 3702 O  O   . HOH R 6 .   ? 7.539   -1.960  9.392  1.00 27.81 ? 890  HOH A O   1 
HETATM 3703 O  O   . HOH R 6 .   ? -3.581  24.049  44.097 1.00 33.95 ? 891  HOH A O   1 
HETATM 3704 O  O   . HOH R 6 .   ? 5.940   19.243  20.310 1.00 15.11 ? 892  HOH A O   1 
HETATM 3705 O  O   . HOH R 6 .   ? -14.326 17.091  21.722 1.00 25.07 ? 893  HOH A O   1 
HETATM 3706 O  O   . HOH R 6 .   ? 10.387  2.525   37.279 1.00 23.34 ? 894  HOH A O   1 
HETATM 3707 O  O   . HOH R 6 .   ? 6.709   1.729   9.832  1.00 13.52 ? 895  HOH A O   1 
HETATM 3708 O  O   . HOH R 6 .   ? 20.620  -10.581 28.472 1.00 15.29 ? 896  HOH A O   1 
HETATM 3709 O  O   . HOH R 6 .   ? 8.301   -27.837 16.514 1.00 27.55 ? 897  HOH A O   1 
HETATM 3710 O  O   . HOH R 6 .   ? -15.356 5.484   -0.498 1.00 35.41 ? 898  HOH A O   1 
HETATM 3711 O  O   . HOH R 6 .   ? 17.825  -16.453 14.487 1.00 32.30 ? 899  HOH A O   1 
HETATM 3712 O  O   . HOH R 6 .   ? -14.569 6.082   30.446 1.00 10.95 ? 900  HOH A O   1 
HETATM 3713 O  O   . HOH R 6 .   ? -3.006  10.032  1.564  1.00 22.56 ? 901  HOH A O   1 
HETATM 3714 O  O   . HOH R 6 .   ? -1.850  -1.948  33.609 1.00 23.82 ? 902  HOH A O   1 
HETATM 3715 O  O   . HOH R 6 .   ? 9.789   -21.448 8.218  1.00 32.18 ? 903  HOH A O   1 
HETATM 3716 O  O   . HOH R 6 .   ? 17.081  7.498   17.910 1.00 23.08 ? 904  HOH A O   1 
HETATM 3717 O  O   . HOH R 6 .   ? -4.980  19.269  22.122 1.00 10.05 ? 905  HOH A O   1 
HETATM 3718 O  O   . HOH R 6 .   ? -12.845 25.089  33.917 1.00 10.98 ? 906  HOH A O   1 
HETATM 3719 O  O   . HOH R 6 .   ? 8.987   -28.191 12.952 1.00 33.52 ? 907  HOH A O   1 
HETATM 3720 O  O   . HOH R 6 .   ? -24.904 3.615   20.190 1.00 15.63 ? 908  HOH A O   1 
HETATM 3721 O  O   . HOH R 6 .   ? -14.229 -25.311 11.692 1.00 14.80 ? 909  HOH A O   1 
HETATM 3722 O  O   . HOH R 6 .   ? -22.020 -1.292  4.598  1.00 21.70 ? 910  HOH A O   1 
HETATM 3723 O  O   . HOH R 6 .   ? -16.917 9.532   8.757  1.00 8.26  ? 911  HOH A O   1 
HETATM 3724 O  O   . HOH R 6 .   ? -9.411  30.439  29.565 1.00 12.72 ? 912  HOH A O   1 
HETATM 3725 O  O   . HOH R 6 .   ? 10.003  -0.039  36.706 1.00 27.55 ? 913  HOH A O   1 
HETATM 3726 O  O   . HOH R 6 .   ? 12.169  -7.634  15.469 1.00 13.92 ? 914  HOH A O   1 
HETATM 3727 O  O   . HOH R 6 .   ? -24.001 4.108   16.313 1.00 28.19 ? 915  HOH A O   1 
HETATM 3728 O  O   . HOH R 6 .   ? -5.134  19.178  42.034 1.00 19.99 ? 916  HOH A O   1 
HETATM 3729 O  O   . HOH R 6 .   ? -11.408 11.514  21.343 1.00 8.15  ? 917  HOH A O   1 
HETATM 3730 O  O   . HOH R 6 .   ? -18.706 7.286   0.782  1.00 23.92 ? 918  HOH A O   1 
HETATM 3731 O  O   . HOH R 6 .   ? -16.475 -13.832 31.212 1.00 16.13 ? 919  HOH A O   1 
HETATM 3732 O  O   . HOH R 6 .   ? 8.871   -24.166 23.342 1.00 30.58 ? 920  HOH A O   1 
HETATM 3733 O  O   . HOH R 6 .   ? 2.083   -30.658 22.367 1.00 33.82 ? 921  HOH A O   1 
HETATM 3734 O  O   . HOH R 6 .   ? 11.955  14.128  33.338 1.00 15.35 ? 922  HOH A O   1 
HETATM 3735 O  O   . HOH R 6 .   ? 9.227   -5.644  11.689 1.00 19.19 ? 923  HOH A O   1 
HETATM 3736 O  O   . HOH R 6 .   ? -30.005 22.726  5.756  1.00 40.83 ? 924  HOH A O   1 
HETATM 3737 O  O   . HOH R 6 .   ? 20.254  -18.892 24.079 1.00 24.50 ? 925  HOH A O   1 
HETATM 3738 O  O   . HOH R 6 .   ? -5.324  29.975  21.530 1.00 28.01 ? 926  HOH A O   1 
HETATM 3739 O  O   . HOH R 6 .   ? -27.550 -5.082  7.001  1.00 32.77 ? 927  HOH A O   1 
HETATM 3740 O  O   . HOH R 6 .   ? -11.158 10.398  24.692 1.00 7.46  ? 928  HOH A O   1 
HETATM 3741 O  O   . HOH R 6 .   ? -8.540  1.325   38.501 1.00 8.72  ? 929  HOH A O   1 
HETATM 3742 O  O   . HOH R 6 .   ? -2.658  -31.768 20.635 1.00 25.98 ? 930  HOH A O   1 
HETATM 3743 O  O   . HOH R 6 .   ? 3.058   18.176  33.778 1.00 13.96 ? 931  HOH A O   1 
HETATM 3744 O  O   . HOH R 6 .   ? -7.854  23.248  22.894 1.00 17.03 ? 932  HOH A O   1 
HETATM 3745 O  O   . HOH R 6 .   ? 1.559   12.476  38.428 1.00 11.97 ? 933  HOH A O   1 
HETATM 3746 O  O   . HOH R 6 .   ? 1.469   -6.501  1.549  1.00 31.14 ? 934  HOH A O   1 
HETATM 3747 O  O   . HOH R 6 .   ? 4.141   3.212   4.610  1.00 25.66 ? 935  HOH A O   1 
HETATM 3748 O  O   . HOH R 6 .   ? -23.086 13.146  9.495  1.00 20.56 ? 936  HOH A O   1 
HETATM 3749 O  O   . HOH R 6 .   ? 17.283  -19.825 21.778 1.00 18.39 ? 937  HOH A O   1 
HETATM 3750 O  O   . HOH R 6 .   ? -2.884  -0.457  0.757  1.00 31.10 ? 938  HOH A O   1 
HETATM 3751 O  O   . HOH R 6 .   ? -13.376 7.007   -0.866 1.00 31.37 ? 939  HOH A O   1 
HETATM 3752 O  O   . HOH R 6 .   ? -12.309 -26.427 8.932  1.00 16.02 ? 940  HOH A O   1 
HETATM 3753 O  O   . HOH R 6 .   ? 15.572  -2.888  18.248 1.00 8.40  ? 941  HOH A O   1 
HETATM 3754 O  O   . HOH R 6 .   ? -4.488  -21.459 17.803 1.00 7.43  ? 942  HOH A O   1 
HETATM 3755 O  O   . HOH R 6 .   ? -17.028 -9.010  28.008 1.00 16.11 ? 943  HOH A O   1 
HETATM 3756 O  O   . HOH R 6 .   ? -3.294  -0.349  41.416 1.00 30.84 ? 944  HOH A O   1 
HETATM 3757 O  O   . HOH R 6 .   ? -28.036 14.173  4.811  1.00 23.44 ? 945  HOH A O   1 
HETATM 3758 O  O   . HOH R 6 .   ? -8.031  -29.740 27.981 1.00 22.80 ? 946  HOH A O   1 
HETATM 3759 O  O   . HOH R 6 .   ? -3.189  2.512   41.726 1.00 27.90 ? 947  HOH A O   1 
HETATM 3760 O  O   . HOH R 6 .   ? 9.477   15.513  11.176 1.00 25.35 ? 948  HOH A O   1 
HETATM 3761 O  O   . HOH R 6 .   ? 17.873  -18.819 29.304 1.00 30.87 ? 949  HOH A O   1 
HETATM 3762 O  O   . HOH R 6 .   ? 2.812   24.696  32.455 1.00 29.98 ? 950  HOH A O   1 
HETATM 3763 O  O   . HOH R 6 .   ? 5.052   -10.157 24.064 1.00 11.14 ? 951  HOH A O   1 
HETATM 3764 O  O   . HOH R 6 .   ? -21.486 -8.518  19.448 1.00 9.09  ? 952  HOH A O   1 
HETATM 3765 O  O   . HOH R 6 .   ? -10.141 -27.942 10.222 1.00 28.20 ? 953  HOH A O   1 
HETATM 3766 O  O   . HOH R 6 .   ? 6.116   1.210   41.858 1.00 28.76 ? 954  HOH A O   1 
HETATM 3767 O  O   . HOH R 6 .   ? -8.954  7.176   35.544 1.00 13.82 ? 955  HOH A O   1 
HETATM 3768 O  O   . HOH R 6 .   ? -12.211 -27.870 13.615 1.00 24.28 ? 956  HOH A O   1 
HETATM 3769 O  O   . HOH R 6 .   ? -18.978 12.036  -2.322 1.00 22.43 ? 957  HOH A O   1 
HETATM 3770 O  O   . HOH R 6 .   ? -23.378 -16.014 16.176 1.00 15.41 ? 958  HOH A O   1 
HETATM 3771 O  O   . HOH R 6 .   ? 8.107   15.469  23.632 1.00 15.38 ? 959  HOH A O   1 
HETATM 3772 O  O   . HOH R 6 .   ? -8.360  4.945   29.757 1.00 7.42  ? 960  HOH A O   1 
HETATM 3773 O  O   . HOH R 6 .   ? 13.930  -4.767  17.003 1.00 12.30 ? 961  HOH A O   1 
HETATM 3774 O  O   . HOH R 6 .   ? 3.744   13.536  31.794 1.00 11.66 ? 962  HOH A O   1 
HETATM 3775 O  O   . HOH R 6 .   ? -30.078 21.139  1.654  1.00 18.04 ? 963  HOH A O   1 
HETATM 3776 O  O   . HOH R 6 .   ? 12.198  -8.099  34.723 1.00 17.30 ? 964  HOH A O   1 
HETATM 3777 O  O   . HOH R 6 .   ? -13.614 28.208  37.295 1.00 11.41 ? 965  HOH A O   1 
HETATM 3778 O  O   . HOH R 6 .   ? -19.926 -1.860  6.454  1.00 9.48  ? 966  HOH A O   1 
HETATM 3779 O  O   . HOH R 6 .   ? -15.642 -1.232  6.073  1.00 9.16  ? 967  HOH A O   1 
HETATM 3780 O  O   . HOH R 6 .   ? -1.788  4.687   35.328 1.00 8.65  ? 968  HOH A O   1 
HETATM 3781 O  O   . HOH R 6 .   ? 0.256   -7.649  32.423 1.00 28.69 ? 969  HOH A O   1 
HETATM 3782 O  O   . HOH R 6 .   ? 15.250  8.205   14.920 1.00 18.37 ? 970  HOH A O   1 
HETATM 3783 O  O   . HOH R 6 .   ? -3.315  -29.342 16.403 1.00 23.73 ? 971  HOH A O   1 
HETATM 3784 O  O   . HOH R 6 .   ? -22.751 10.295  14.094 1.00 40.58 ? 972  HOH A O   1 
HETATM 3785 O  O   . HOH R 6 .   ? -18.571 -4.211  5.478  1.00 8.31  ? 973  HOH A O   1 
HETATM 3786 O  O   . HOH R 6 .   ? -0.753  20.433  17.214 1.00 17.06 ? 974  HOH A O   1 
HETATM 3787 O  O   . HOH R 6 .   ? 6.886   18.350  42.084 1.00 27.49 ? 975  HOH A O   1 
HETATM 3788 O  O   . HOH R 6 .   ? -2.900  31.377  6.440  1.00 36.38 ? 976  HOH A O   1 
HETATM 3789 O  O   . HOH R 6 .   ? 0.819   -10.011 3.585  1.00 25.97 ? 977  HOH A O   1 
HETATM 3790 O  O   . HOH R 6 .   ? 8.869   16.411  2.567  1.00 24.27 ? 978  HOH A O   1 
HETATM 3791 O  O   . HOH R 6 .   ? 5.884   -22.869 9.480  1.00 18.02 ? 979  HOH A O   1 
HETATM 3792 O  O   . HOH R 6 .   ? 0.650   20.880  13.929 1.00 30.04 ? 980  HOH A O   1 
HETATM 3793 O  O   A HOH R 6 .   ? -0.589  -3.745  30.844 0.80 18.47 ? 981  HOH A O   1 
HETATM 3794 O  O   B HOH R 6 .   ? -0.198  -3.803  32.121 0.20 8.42  ? 981  HOH A O   1 
HETATM 3795 O  O   . HOH R 6 .   ? 8.673   19.403  20.483 1.00 30.72 ? 982  HOH A O   1 
HETATM 3796 O  O   . HOH R 6 .   ? -24.135 -2.750  19.793 1.00 17.23 ? 983  HOH A O   1 
HETATM 3797 O  O   . HOH R 6 .   ? -19.191 -16.557 15.346 1.00 25.97 ? 984  HOH A O   1 
HETATM 3798 O  O   A HOH R 6 .   ? 0.000   13.675  40.693 0.80 19.37 ? 985  HOH A O   1 
HETATM 3799 O  O   B HOH R 6 .   ? -0.767  13.714  41.747 0.20 4.54  ? 985  HOH A O   1 
HETATM 3800 O  O   . HOH R 6 .   ? -2.186  23.195  40.819 1.00 39.24 ? 986  HOH A O   1 
HETATM 3801 O  O   . HOH R 6 .   ? -20.120 -19.658 30.019 1.00 30.83 ? 987  HOH A O   1 
HETATM 3802 O  O   . HOH R 6 .   ? 1.756   -8.881  6.065  1.00 26.84 ? 988  HOH A O   1 
HETATM 3803 O  O   . HOH R 6 .   ? -11.366 -24.745 -0.204 1.00 29.74 ? 989  HOH A O   1 
HETATM 3804 O  O   . HOH R 6 .   ? 16.031  -10.380 29.801 1.00 23.07 ? 990  HOH A O   1 
HETATM 3805 O  O   . HOH R 6 .   ? -21.898 -11.065 11.885 1.00 16.52 ? 991  HOH A O   1 
HETATM 3806 O  O   . HOH R 6 .   ? 3.428   15.080  20.457 1.00 9.48  ? 992  HOH A O   1 
HETATM 3807 O  O   . HOH R 6 .   ? 7.840   20.463  32.555 1.00 38.40 ? 993  HOH A O   1 
HETATM 3808 O  O   . HOH R 6 .   ? -13.626 26.347  27.286 1.00 19.77 ? 994  HOH A O   1 
HETATM 3809 O  O   . HOH R 6 .   ? 15.142  8.048   38.282 1.00 35.80 ? 995  HOH A O   1 
HETATM 3810 O  O   . HOH R 6 .   ? 2.935   -21.308 25.899 1.00 9.93  ? 996  HOH A O   1 
HETATM 3811 O  O   . HOH R 6 .   ? 11.986  -14.098 11.945 1.00 12.26 ? 997  HOH A O   1 
HETATM 3812 O  O   . HOH R 6 .   ? -27.287 20.113  5.517  1.00 34.22 ? 998  HOH A O   1 
HETATM 3813 O  O   . HOH R 6 .   ? 0.479   -23.537 14.623 1.00 18.76 ? 999  HOH A O   1 
HETATM 3814 O  O   . HOH R 6 .   ? 6.266   4.574   6.056  1.00 13.16 ? 1000 HOH A O   1 
HETATM 3815 O  O   . HOH R 6 .   ? -17.016 17.792  36.175 1.00 34.71 ? 1001 HOH A O   1 
HETATM 3816 O  O   . HOH R 6 .   ? -19.971 -2.222  21.778 1.00 10.08 ? 1002 HOH A O   1 
HETATM 3817 O  O   . HOH R 6 .   ? -7.196  -22.480 33.004 1.00 16.53 ? 1003 HOH A O   1 
HETATM 3818 O  O   . HOH R 6 .   ? -17.793 -12.752 29.033 1.00 13.67 ? 1004 HOH A O   1 
HETATM 3819 O  O   . HOH R 6 .   ? 3.488   22.025  34.096 1.00 32.62 ? 1005 HOH A O   1 
HETATM 3820 O  O   . HOH R 6 .   ? 11.924  -1.066  33.004 1.00 19.85 ? 1006 HOH A O   1 
HETATM 3821 O  O   . HOH R 6 .   ? -15.964 15.378  36.979 1.00 16.18 ? 1007 HOH A O   1 
HETATM 3822 O  O   . HOH R 6 .   ? 3.907   24.395  6.510  1.00 37.17 ? 1008 HOH A O   1 
HETATM 3823 O  O   . HOH R 6 .   ? 5.008   19.823  35.251 1.00 26.78 ? 1009 HOH A O   1 
HETATM 3824 O  O   . HOH R 6 .   ? -18.915 28.970  2.485  1.00 26.07 ? 1010 HOH A O   1 
HETATM 3825 O  O   . HOH R 6 .   ? -12.276 25.029  2.407  1.00 25.46 ? 1011 HOH A O   1 
HETATM 3826 O  O   . HOH R 6 .   ? 12.253  12.771  8.461  1.00 21.69 ? 1012 HOH A O   1 
HETATM 3827 O  O   . HOH R 6 .   ? -5.439  -20.196 28.990 1.00 7.91  ? 1013 HOH A O   1 
HETATM 3828 O  O   . HOH R 6 .   ? 8.673   -1.628  34.567 1.00 12.30 ? 1014 HOH A O   1 
HETATM 3829 O  O   . HOH R 6 .   ? -19.886 2.491   22.779 1.00 33.34 ? 1015 HOH A O   1 
HETATM 3830 O  O   . HOH R 6 .   ? -18.871 -20.335 13.195 1.00 14.55 ? 1016 HOH A O   1 
HETATM 3831 O  O   . HOH R 6 .   ? 0.951   25.626  31.431 1.00 26.54 ? 1017 HOH A O   1 
HETATM 3832 O  O   . HOH R 6 .   ? -17.281 0.761   29.424 1.00 17.25 ? 1018 HOH A O   1 
HETATM 3833 O  O   . HOH R 6 .   ? 10.465  -20.263 30.131 1.00 31.22 ? 1019 HOH A O   1 
HETATM 3834 O  O   A HOH R 6 .   ? 2.731   -11.117 32.328 0.50 13.67 ? 1020 HOH A O   1 
HETATM 3835 O  O   B HOH R 6 .   ? 2.173   -9.966  32.950 0.50 15.86 ? 1020 HOH A O   1 
HETATM 3836 O  O   . HOH R 6 .   ? -21.557 -18.850 19.367 1.00 24.38 ? 1021 HOH A O   1 
HETATM 3837 O  O   . HOH R 6 .   ? -1.516  -23.203 10.947 1.00 18.19 ? 1022 HOH A O   1 
HETATM 3838 O  O   . HOH R 6 .   ? -8.561  -30.970 20.702 1.00 14.19 ? 1023 HOH A O   1 
HETATM 3839 O  O   . HOH R 6 .   ? -7.675  -25.209 32.490 1.00 20.42 ? 1024 HOH A O   1 
HETATM 3840 O  O   . HOH R 6 .   ? 8.253   14.939  14.589 1.00 14.11 ? 1025 HOH A O   1 
HETATM 3841 O  O   . HOH R 6 .   ? 4.738   -13.029 33.220 1.00 22.68 ? 1026 HOH A O   1 
HETATM 3842 O  O   . HOH R 6 .   ? -3.122  23.985  22.830 1.00 22.87 ? 1027 HOH A O   1 
HETATM 3843 O  O   . HOH R 6 .   ? 1.882   21.838  35.867 1.00 29.00 ? 1028 HOH A O   1 
HETATM 3844 O  O   . HOH R 6 .   ? -16.097 -1.634  29.350 1.00 20.24 ? 1029 HOH A O   1 
HETATM 3845 O  O   . HOH R 6 .   ? 4.116   19.894  12.944 1.00 21.67 ? 1030 HOH A O   1 
HETATM 3846 O  O   . HOH R 6 .   ? -13.285 25.696  14.919 1.00 30.30 ? 1031 HOH A O   1 
HETATM 3847 O  O   . HOH R 6 .   ? 2.829   5.529   -7.014 1.00 38.31 ? 1032 HOH A O   1 
HETATM 3848 O  O   . HOH R 6 .   ? -26.438 2.174   12.712 1.00 26.47 ? 1033 HOH A O   1 
HETATM 3849 O  O   . HOH R 6 .   ? -2.246  8.094   -1.867 1.00 39.22 ? 1034 HOH A O   1 
HETATM 3850 O  O   . HOH R 6 .   ? -7.442  18.790  20.885 1.00 9.91  ? 1035 HOH A O   1 
HETATM 3851 O  O   . HOH R 6 .   ? 7.200   18.735  34.117 1.00 25.42 ? 1036 HOH A O   1 
HETATM 3852 O  O   . HOH R 6 .   ? 6.386   21.417  27.145 1.00 20.56 ? 1037 HOH A O   1 
HETATM 3853 O  O   . HOH R 6 .   ? 14.035  -16.312 11.445 1.00 21.62 ? 1038 HOH A O   1 
HETATM 3854 O  O   . HOH R 6 .   ? 2.095   21.045  38.286 1.00 23.60 ? 1039 HOH A O   1 
HETATM 3855 O  O   . HOH R 6 .   ? -15.138 -29.759 24.009 1.00 29.73 ? 1040 HOH A O   1 
HETATM 3856 O  O   . HOH R 6 .   ? 18.670  -16.699 27.770 1.00 15.52 ? 1041 HOH A O   1 
HETATM 3857 O  O   . HOH R 6 .   ? 0.401   -3.422  28.122 1.00 8.36  ? 1042 HOH A O   1 
HETATM 3858 O  O   . HOH R 6 .   ? -15.397 22.054  29.844 1.00 21.45 ? 1043 HOH A O   1 
HETATM 3859 O  O   . HOH R 6 .   ? 2.156   1.789   40.779 1.00 14.32 ? 1044 HOH A O   1 
HETATM 3860 O  O   . HOH R 6 .   ? -26.852 29.476  8.195  1.00 34.61 ? 1045 HOH A O   1 
HETATM 3861 O  O   . HOH R 6 .   ? -9.004  -12.399 -0.865 1.00 22.94 ? 1046 HOH A O   1 
HETATM 3862 O  O   . HOH R 6 .   ? -12.302 -15.504 33.551 1.00 33.21 ? 1047 HOH A O   1 
HETATM 3863 O  O   . HOH R 6 .   ? -21.197 -26.553 10.143 1.00 42.54 ? 1048 HOH A O   1 
HETATM 3864 O  O   . HOH R 6 .   ? -13.717 -12.232 -0.208 1.00 10.47 ? 1049 HOH A O   1 
HETATM 3865 O  O   . HOH R 6 .   ? 4.775   19.091  17.826 1.00 17.40 ? 1050 HOH A O   1 
HETATM 3866 O  O   . HOH R 6 .   ? 1.908   12.221  42.654 1.00 23.26 ? 1051 HOH A O   1 
HETATM 3867 O  O   . HOH R 6 .   ? -11.041 -13.464 0.507  1.00 13.10 ? 1052 HOH A O   1 
HETATM 3868 O  O   . HOH R 6 .   ? -20.887 -9.990  10.036 1.00 25.26 ? 1053 HOH A O   1 
HETATM 3869 O  O   . HOH R 6 .   ? -33.153 -9.500  7.808  1.00 29.71 ? 1054 HOH A O   1 
HETATM 3870 O  O   . HOH R 6 .   ? 13.849  9.740   29.037 1.00 14.44 ? 1055 HOH A O   1 
HETATM 3871 O  O   . HOH R 6 .   ? -9.334  -12.416 21.504 1.00 7.13  ? 1056 HOH A O   1 
HETATM 3872 O  O   . HOH R 6 .   ? 2.642   10.653  28.326 1.00 23.75 ? 1057 HOH A O   1 
HETATM 3873 O  O   . HOH R 6 .   ? -18.423 16.264  19.058 1.00 32.91 ? 1058 HOH A O   1 
HETATM 3874 O  O   . HOH R 6 .   ? 13.695  14.595  27.993 1.00 30.11 ? 1059 HOH A O   1 
HETATM 3875 O  O   . HOH R 6 .   ? 11.696  -3.376  34.782 1.00 31.14 ? 1060 HOH A O   1 
HETATM 3876 O  O   . HOH R 6 .   ? -4.900  -11.420 -0.605 1.00 31.78 ? 1061 HOH A O   1 
HETATM 3877 O  O   . HOH R 6 .   ? 13.075  -12.993 32.767 1.00 24.73 ? 1062 HOH A O   1 
HETATM 3878 O  O   . HOH R 6 .   ? -16.659 -26.453 8.743  1.00 28.58 ? 1063 HOH A O   1 
HETATM 3879 O  O   . HOH R 6 .   ? 11.979  -9.152  27.055 1.00 8.81  ? 1064 HOH A O   1 
HETATM 3880 O  O   . HOH R 6 .   ? -16.820 19.988  27.056 1.00 27.70 ? 1065 HOH A O   1 
HETATM 3881 O  O   . HOH R 6 .   ? -5.989  -9.096  33.048 1.00 25.93 ? 1066 HOH A O   1 
HETATM 3882 O  O   . HOH R 6 .   ? 9.909   -23.244 20.939 1.00 13.34 ? 1067 HOH A O   1 
HETATM 3883 O  O   . HOH R 6 .   ? -11.367 25.814  23.167 1.00 30.53 ? 1068 HOH A O   1 
HETATM 3884 O  O   . HOH R 6 .   ? 0.753   5.028   42.057 1.00 29.18 ? 1069 HOH A O   1 
HETATM 3885 O  O   . HOH R 6 .   ? -20.265 11.348  18.992 1.00 21.92 ? 1070 HOH A O   1 
HETATM 3886 O  O   . HOH R 6 .   ? -15.667 -19.891 28.575 1.00 20.19 ? 1071 HOH A O   1 
HETATM 3887 O  O   . HOH R 6 .   ? -16.537 -10.444 30.104 1.00 23.73 ? 1072 HOH A O   1 
HETATM 3888 O  O   . HOH R 6 .   ? -12.417 20.823  23.211 1.00 36.02 ? 1073 HOH A O   1 
HETATM 3889 O  O   . HOH R 6 .   ? -21.912 15.681  -4.945 1.00 25.47 ? 1074 HOH A O   1 
HETATM 3890 O  O   A HOH R 6 .   ? 19.748  -1.695  24.403 0.50 19.74 ? 1075 HOH A O   1 
HETATM 3891 O  O   B HOH R 6 .   ? 20.594  -3.256  24.063 0.50 13.77 ? 1075 HOH A O   1 
HETATM 3892 O  O   . HOH R 6 .   ? 15.640  -8.471  14.469 1.00 30.58 ? 1076 HOH A O   1 
HETATM 3893 O  O   . HOH R 6 .   ? -23.059 7.021   20.310 1.00 35.96 ? 1077 HOH A O   1 
HETATM 3894 O  O   . HOH R 6 .   ? 6.741   15.470  16.815 1.00 15.74 ? 1078 HOH A O   1 
HETATM 3895 O  O   . HOH R 6 .   ? 14.281  -21.230 10.678 1.00 37.12 ? 1079 HOH A O   1 
HETATM 3896 O  O   . HOH R 6 .   ? 6.082   22.710  31.430 1.00 40.59 ? 1080 HOH A O   1 
HETATM 3897 O  O   . HOH R 6 .   ? -1.886  8.743   -6.021 1.00 37.74 ? 1081 HOH A O   1 
HETATM 3898 O  O   . HOH R 6 .   ? -21.884 0.768   23.496 1.00 38.57 ? 1082 HOH A O   1 
HETATM 3899 O  O   . HOH R 6 .   ? 9.368   -6.800  37.791 1.00 34.57 ? 1083 HOH A O   1 
HETATM 3900 O  O   . HOH R 6 .   ? -5.304  -6.386  31.718 1.00 16.59 ? 1084 HOH A O   1 
HETATM 3901 O  O   . HOH R 6 .   ? 7.492   -17.590 29.789 1.00 19.77 ? 1085 HOH A O   1 
HETATM 3902 O  O   . HOH R 6 .   ? -24.477 25.161  11.057 1.00 37.94 ? 1086 HOH A O   1 
HETATM 3903 O  O   . HOH R 6 .   ? -16.258 -21.735 24.618 1.00 29.78 ? 1087 HOH A O   1 
HETATM 3904 O  O   . HOH R 6 .   ? -3.473  13.039  -0.598 1.00 32.52 ? 1088 HOH A O   1 
HETATM 3905 O  O   . HOH R 6 .   ? -3.017  28.669  41.173 1.00 34.79 ? 1089 HOH A O   1 
HETATM 3906 O  O   . HOH R 6 .   ? 1.656   -2.877  6.686  1.00 23.32 ? 1090 HOH A O   1 
HETATM 3907 O  O   . HOH R 6 .   ? 16.984  5.903   14.961 1.00 35.43 ? 1091 HOH A O   1 
HETATM 3908 O  O   . HOH R 6 .   ? -16.750 4.491   31.359 1.00 18.12 ? 1092 HOH A O   1 
HETATM 3909 O  O   . HOH R 6 .   ? -22.328 -17.249 26.152 1.00 16.38 ? 1093 HOH A O   1 
HETATM 3910 O  O   . HOH R 6 .   ? -16.656 -21.522 22.289 1.00 28.30 ? 1094 HOH A O   1 
HETATM 3911 O  O   . HOH R 6 .   ? -26.224 -6.194  8.532  1.00 41.45 ? 1095 HOH A O   1 
HETATM 3912 O  O   . HOH R 6 .   ? -13.798 21.947  17.743 1.00 42.21 ? 1096 HOH A O   1 
HETATM 3913 O  O   . HOH R 6 .   ? -27.260 -1.554  9.431  1.00 41.08 ? 1097 HOH A O   1 
HETATM 3914 O  O   . HOH R 6 .   ? 6.244   -6.138  36.592 1.00 43.25 ? 1098 HOH A O   1 
HETATM 3915 O  O   . HOH R 6 .   ? 10.512  -9.073  10.663 1.00 22.99 ? 1099 HOH A O   1 
HETATM 3916 O  O   . HOH R 6 .   ? 3.387   3.396   42.733 1.00 25.51 ? 1100 HOH A O   1 
HETATM 3917 O  O   A HOH R 6 .   ? -0.529  6.066   2.367  0.70 23.85 ? 1101 HOH A O   1 
HETATM 3918 O  O   B HOH R 6 .   ? -1.431  5.558   0.931  0.30 19.64 ? 1101 HOH A O   1 
HETATM 3919 O  O   . HOH R 6 .   ? -4.475  27.242  0.967  1.00 34.00 ? 1102 HOH A O   1 
HETATM 3920 O  O   . HOH R 6 .   ? 6.606   17.545  8.905  1.00 25.14 ? 1103 HOH A O   1 
HETATM 3921 O  O   . HOH R 6 .   ? -11.394 21.466  20.111 1.00 37.07 ? 1104 HOH A O   1 
HETATM 3922 O  O   . HOH R 6 .   ? -31.574 -4.189  2.213  1.00 42.37 ? 1105 HOH A O   1 
HETATM 3923 O  O   . HOH R 6 .   ? 19.872  3.537   26.469 1.00 40.05 ? 1106 HOH A O   1 
HETATM 3924 O  O   . HOH R 6 .   ? -23.087 6.797   15.789 1.00 28.59 ? 1107 HOH A O   1 
HETATM 3925 O  O   . HOH R 6 .   ? 21.802  -16.953 18.111 1.00 36.74 ? 1108 HOH A O   1 
HETATM 3926 O  O   . HOH R 6 .   ? -25.055 9.015   3.512  1.00 41.84 ? 1109 HOH A O   1 
HETATM 3927 O  O   . HOH R 6 .   ? -16.308 1.838   32.256 1.00 21.56 ? 1110 HOH A O   1 
HETATM 3928 O  O   . HOH R 6 .   ? -25.420 -10.268 9.333  1.00 39.30 ? 1111 HOH A O   1 
HETATM 3929 O  O   . HOH R 6 .   ? 8.072   -21.259 29.345 1.00 40.60 ? 1112 HOH A O   1 
HETATM 3930 O  O   . HOH R 6 .   ? -4.773  14.612  25.680 1.00 7.54  ? 1113 HOH A O   1 
HETATM 3931 O  O   . HOH R 6 .   ? 0.748   -11.675 1.509  1.00 30.34 ? 1114 HOH A O   1 
HETATM 3932 O  O   . HOH R 6 .   ? 0.578   -3.672  34.230 1.00 24.83 ? 1115 HOH A O   1 
HETATM 3933 O  O   . HOH R 6 .   ? 0.342   -30.024 24.240 1.00 30.35 ? 1116 HOH A O   1 
HETATM 3934 O  O   . HOH R 6 .   ? -10.870 3.590   1.462  1.00 30.44 ? 1117 HOH A O   1 
HETATM 3935 O  O   . HOH R 6 .   ? 11.294  15.511  38.404 1.00 24.34 ? 1118 HOH A O   1 
HETATM 3936 O  O   . HOH R 6 .   ? 18.440  6.163   23.619 1.00 25.12 ? 1119 HOH A O   1 
HETATM 3937 O  O   . HOH R 6 .   ? 13.493  -4.802  32.991 1.00 25.74 ? 1120 HOH A O   1 
HETATM 3938 O  O   . HOH R 6 .   ? 7.939   5.900   4.102  1.00 23.99 ? 1121 HOH A O   1 
HETATM 3939 O  O   . HOH R 6 .   ? 7.469   15.258  21.450 1.00 30.00 ? 1122 HOH A O   1 
HETATM 3940 O  O   . HOH R 6 .   ? 4.333   -23.498 7.235  1.00 32.50 ? 1123 HOH A O   1 
HETATM 3941 O  O   . HOH R 6 .   ? -2.625  -2.840  35.825 1.00 31.79 ? 1124 HOH A O   1 
HETATM 3942 O  O   . HOH R 6 .   ? 11.507  15.204  1.129  1.00 33.42 ? 1125 HOH A O   1 
HETATM 3943 O  O   . HOH R 6 .   ? 2.899   -11.258 6.461  1.00 22.30 ? 1126 HOH A O   1 
HETATM 3944 O  O   . HOH R 6 .   ? 8.341   -11.879 7.512  1.00 24.59 ? 1127 HOH A O   1 
HETATM 3945 O  O   . HOH R 6 .   ? -12.767 27.519  29.847 1.00 13.33 ? 1128 HOH A O   1 
HETATM 3946 O  O   . HOH R 6 .   ? -2.074  30.003  36.007 1.00 27.19 ? 1129 HOH A O   1 
HETATM 3947 O  O   . HOH R 6 .   ? 4.109   20.978  10.495 1.00 29.69 ? 1130 HOH A O   1 
HETATM 3948 O  O   . HOH R 6 .   ? -2.318  -5.627  32.196 1.00 27.63 ? 1131 HOH A O   1 
HETATM 3949 O  O   . HOH R 6 .   ? -2.792  -29.313 29.391 1.00 26.97 ? 1132 HOH A O   1 
HETATM 3950 O  O   . HOH R 6 .   ? 7.707   23.103  25.436 1.00 37.14 ? 1133 HOH A O   1 
HETATM 3951 O  O   . HOH R 6 .   ? -1.846  13.222  43.737 1.00 29.44 ? 1134 HOH A O   1 
HETATM 3952 O  O   . HOH R 6 .   ? 8.195   -7.138  7.086  1.00 38.05 ? 1135 HOH A O   1 
HETATM 3953 O  O   . HOH R 6 .   ? -12.756 2.336   0.878  1.00 34.18 ? 1136 HOH A O   1 
HETATM 3954 O  O   A HOH R 6 .   ? 6.610   -3.421  36.458 0.80 26.96 ? 1137 HOH A O   1 
HETATM 3955 O  O   B HOH R 6 .   ? 4.737   -3.281  36.549 0.20 10.83 ? 1137 HOH A O   1 
HETATM 3956 O  O   . HOH R 6 .   ? -22.192 -14.418 9.268  1.00 28.36 ? 1138 HOH A O   1 
HETATM 3957 O  O   . HOH R 6 .   ? 0.679   7.508   42.327 1.00 32.10 ? 1139 HOH A O   1 
HETATM 3958 O  O   . HOH R 6 .   ? -15.687 17.381  19.377 1.00 22.94 ? 1140 HOH A O   1 
HETATM 3959 O  O   . HOH R 6 .   ? 11.626  13.235  37.616 1.00 44.01 ? 1141 HOH A O   1 
HETATM 3960 O  O   . HOH R 6 .   ? 11.646  9.061   10.154 1.00 26.07 ? 1142 HOH A O   1 
HETATM 3961 O  O   . HOH R 6 .   ? -23.443 7.142   1.608  1.00 41.34 ? 1143 HOH A O   1 
HETATM 3962 O  O   . HOH R 6 .   ? 6.218   18.729  13.402 1.00 25.52 ? 1144 HOH A O   1 
HETATM 3963 O  O   . HOH R 6 .   ? -16.059 -0.775  3.371  1.00 16.24 ? 1145 HOH A O   1 
HETATM 3964 O  O   . HOH R 6 .   ? 2.903   -23.831 12.083 1.00 31.01 ? 1146 HOH A O   1 
HETATM 3965 O  O   . HOH R 6 .   ? -12.963 -30.438 14.577 1.00 34.70 ? 1147 HOH A O   1 
HETATM 3966 O  O   . HOH R 6 .   ? -16.488 25.956  11.970 1.00 25.64 ? 1148 HOH A O   1 
HETATM 3967 O  O   . HOH R 6 .   ? -14.566 -22.128 29.635 1.00 22.33 ? 1149 HOH A O   1 
HETATM 3968 O  O   . HOH R 6 .   ? -20.564 -21.527 15.102 1.00 39.37 ? 1150 HOH A O   1 
HETATM 3969 O  O   . HOH R 6 .   ? 10.209  9.911   4.015  1.00 42.07 ? 1151 HOH A O   1 
HETATM 3970 O  O   . HOH R 6 .   ? 0.012   0.850   41.975 1.00 35.04 ? 1152 HOH A O   1 
HETATM 3971 O  O   . HOH R 6 .   ? -13.030 8.628   38.798 1.00 28.35 ? 1153 HOH A O   1 
HETATM 3972 O  O   . HOH R 6 .   ? 11.890  -13.543 9.260  1.00 33.14 ? 1154 HOH A O   1 
HETATM 3973 O  O   . HOH R 6 .   ? 12.003  10.521  41.662 1.00 36.33 ? 1155 HOH A O   1 
HETATM 3974 O  O   . HOH R 6 .   ? -5.611  -30.508 16.695 1.00 27.77 ? 1156 HOH A O   1 
HETATM 3975 O  O   . HOH R 6 .   ? 5.801   -10.884 6.520  1.00 29.29 ? 1157 HOH A O   1 
HETATM 3976 O  O   . HOH R 6 .   ? -22.091 12.209  -3.549 1.00 37.05 ? 1158 HOH A O   1 
HETATM 3977 O  O   . HOH R 6 .   ? -15.635 -3.982  -0.208 1.00 33.92 ? 1159 HOH A O   1 
HETATM 3978 O  O   . HOH R 6 .   ? -8.653  7.097   2.607  1.00 31.20 ? 1160 HOH A O   1 
HETATM 3979 O  O   . HOH R 6 .   ? 6.582   16.259  12.683 1.00 18.00 ? 1161 HOH A O   1 
HETATM 3980 O  O   . HOH R 6 .   ? -18.449 18.221  33.758 1.00 36.76 ? 1162 HOH A O   1 
HETATM 3981 O  O   . HOH R 6 .   ? 14.477  11.112  31.200 1.00 25.96 ? 1163 HOH A O   1 
HETATM 3982 O  O   . HOH R 6 .   ? 2.792   -24.082 26.309 1.00 20.43 ? 1164 HOH A O   1 
HETATM 3983 O  O   . HOH R 6 .   ? -20.175 -13.921 29.980 1.00 30.28 ? 1165 HOH A O   1 
HETATM 3984 O  O   . HOH R 6 .   ? -11.778 13.776  -3.196 1.00 39.31 ? 1166 HOH A O   1 
HETATM 3985 O  O   . HOH R 6 .   ? -22.635 -1.693  21.822 1.00 14.37 ? 1167 HOH A O   1 
HETATM 3986 O  O   . HOH R 6 .   ? -3.457  -12.182 33.898 1.00 28.70 ? 1168 HOH A O   1 
HETATM 3987 O  O   . HOH R 6 .   ? -22.763 -12.598 5.812  1.00 29.90 ? 1169 HOH A O   1 
HETATM 3988 O  O   . HOH R 6 .   ? -18.639 4.448   2.130  1.00 23.19 ? 1170 HOH A O   1 
HETATM 3989 O  O   . HOH R 6 .   ? 12.876  -2.435  31.415 1.00 14.83 ? 1171 HOH A O   1 
HETATM 3990 O  O   . HOH R 6 .   ? 0.132   26.061  36.638 1.00 35.33 ? 1172 HOH A O   1 
HETATM 3991 O  O   . HOH R 6 .   ? -22.594 -14.895 11.801 1.00 30.97 ? 1173 HOH A O   1 
HETATM 3992 O  O   . HOH R 6 .   ? -22.219 -3.149  2.704  1.00 35.00 ? 1174 HOH A O   1 
HETATM 3993 O  O   . HOH R 6 .   ? -20.988 8.049   26.471 1.00 39.77 ? 1175 HOH A O   1 
HETATM 3994 O  O   . HOH R 6 .   ? -15.829 -27.354 11.371 1.00 31.29 ? 1176 HOH A O   1 
HETATM 3995 O  O   . HOH R 6 .   ? -6.290  -32.138 18.915 1.00 31.06 ? 1177 HOH A O   1 
HETATM 3996 O  O   . HOH R 6 .   ? -23.912 10.626  19.733 1.00 35.81 ? 1178 HOH A O   1 
HETATM 3997 O  O   . HOH R 6 .   ? -1.187  -24.964 27.744 1.00 11.53 ? 1179 HOH A O   1 
HETATM 3998 O  O   . HOH R 6 .   ? -12.160 18.637  21.271 1.00 21.68 ? 1180 HOH A O   1 
HETATM 3999 O  O   . HOH R 6 .   ? -26.898 -3.155  -2.860 1.00 26.01 ? 1181 HOH A O   1 
HETATM 4000 O  O   . HOH R 6 .   ? 10.568  16.452  14.588 1.00 30.98 ? 1182 HOH A O   1 
HETATM 4001 O  O   . HOH R 6 .   ? -12.191 30.292  29.534 1.00 10.15 ? 1183 HOH A O   1 
HETATM 4002 O  O   . HOH R 6 .   ? 0.341   26.238  28.859 1.00 21.05 ? 1184 HOH A O   1 
HETATM 4003 O  O   . HOH R 6 .   ? 12.824  11.372  10.812 1.00 30.55 ? 1185 HOH A O   1 
HETATM 4004 O  O   . HOH R 6 .   ? -1.399  -27.153 29.455 1.00 20.54 ? 1186 HOH A O   1 
HETATM 4005 O  O   . HOH R 6 .   ? -20.047 -26.655 15.717 1.00 42.41 ? 1187 HOH A O   1 
HETATM 4006 O  O   . HOH R 6 .   ? 0.692   22.658  39.729 1.00 30.68 ? 1188 HOH A O   1 
HETATM 4007 O  O   . HOH R 6 .   ? -19.063 15.033  23.438 1.00 30.64 ? 1189 HOH A O   1 
HETATM 4008 O  O   . HOH R 6 .   ? 5.604   -0.986  40.006 1.00 34.21 ? 1190 HOH A O   1 
HETATM 4009 O  O   . HOH R 6 .   ? 22.269  4.261   24.258 1.00 30.26 ? 1191 HOH A O   1 
HETATM 4010 O  O   . HOH R 6 .   ? -15.739 1.503   1.881  1.00 23.91 ? 1192 HOH A O   1 
HETATM 4011 O  O   . HOH R 6 .   ? 1.761   -7.875  35.018 1.00 33.54 ? 1193 HOH A O   1 
HETATM 4012 O  O   . HOH R 6 .   ? -18.435 8.328   34.044 1.00 39.78 ? 1194 HOH A O   1 
HETATM 4013 O  O   . HOH R 6 .   ? -13.368 -30.319 31.768 1.00 10.22 ? 1195 HOH A O   1 
HETATM 4014 O  O   . HOH R 6 .   ? 19.452  -12.809 29.572 1.00 20.64 ? 1196 HOH A O   1 
HETATM 4015 O  O   . HOH R 6 .   ? 13.414  -10.038 13.499 1.00 32.84 ? 1197 HOH A O   1 
HETATM 4016 O  O   . HOH R 6 .   ? -14.850 -27.871 8.343  1.00 32.32 ? 1198 HOH A O   1 
HETATM 4017 O  O   . HOH R 6 .   ? -21.284 -17.699 15.026 1.00 33.06 ? 1199 HOH A O   1 
HETATM 4018 O  O   . HOH R 6 .   ? -19.496 28.575  10.227 1.00 30.88 ? 1200 HOH A O   1 
HETATM 4019 O  O   . HOH R 6 .   ? -15.709 29.027  5.609  1.00 34.31 ? 1201 HOH A O   1 
HETATM 4020 O  O   . HOH R 6 .   ? -11.290 29.326  13.942 1.00 39.34 ? 1202 HOH A O   1 
HETATM 4021 O  O   . HOH R 6 .   ? -0.054  22.265  19.147 1.00 38.61 ? 1203 HOH A O   1 
HETATM 4022 O  O   . HOH R 6 .   ? -6.535  -0.550  38.895 1.00 9.85  ? 1204 HOH A O   1 
HETATM 4023 O  O   . HOH R 6 .   ? -21.378 19.742  17.474 1.00 42.10 ? 1205 HOH A O   1 
HETATM 4024 O  O   . HOH R 6 .   ? 3.109   19.145  42.252 1.00 24.17 ? 1206 HOH A O   1 
HETATM 4025 O  O   . HOH R 6 .   ? -24.270 5.496   18.577 1.00 31.72 ? 1207 HOH A O   1 
HETATM 4026 O  O   . HOH R 6 .   ? 6.009   -15.124 29.334 1.00 13.64 ? 1208 HOH A O   1 
HETATM 4027 O  O   . HOH R 6 .   ? -13.786 24.257  38.233 1.00 15.54 ? 1209 HOH A O   1 
HETATM 4028 O  O   . HOH R 6 .   ? 11.341  -8.139  37.422 1.00 37.95 ? 1210 HOH A O   1 
HETATM 4029 O  O   . HOH R 6 .   ? -1.269  24.714  15.257 1.00 32.14 ? 1211 HOH A O   1 
HETATM 4030 O  O   . HOH R 6 .   ? 9.593   -19.600 6.731  1.00 34.05 ? 1212 HOH A O   1 
HETATM 4031 O  O   . HOH R 6 .   ? -14.347 25.869  36.069 1.00 12.99 ? 1213 HOH A O   1 
HETATM 4032 O  O   . HOH R 6 .   ? 6.810   18.464  16.212 1.00 27.68 ? 1214 HOH A O   1 
HETATM 4033 O  O   . HOH R 6 .   ? 4.822   21.335  39.174 1.00 27.96 ? 1215 HOH A O   1 
HETATM 4034 O  O   . HOH R 6 .   ? -18.338 -3.829  2.687  1.00 19.23 ? 1216 HOH A O   1 
HETATM 4035 O  O   . HOH R 6 .   ? 13.634  14.288  30.455 1.00 41.87 ? 1217 HOH A O   1 
HETATM 4036 O  O   . HOH R 6 .   ? 11.176  -2.296  9.893  1.00 36.03 ? 1218 HOH A O   1 
HETATM 4037 O  O   . HOH R 6 .   ? -19.676 14.663  20.973 1.00 37.32 ? 1219 HOH A O   1 
HETATM 4038 O  O   . HOH R 6 .   ? 2.166   -1.972  37.691 1.00 28.38 ? 1220 HOH A O   1 
HETATM 4039 O  O   . HOH R 6 .   ? 3.229   -20.598 30.182 1.00 29.31 ? 1221 HOH A O   1 
HETATM 4040 O  O   . HOH R 6 .   ? 8.527   -15.173 33.087 1.00 25.06 ? 1222 HOH A O   1 
HETATM 4041 O  O   . HOH R 6 .   ? -4.067  37.040  38.706 1.00 30.39 ? 1223 HOH A O   1 
HETATM 4042 O  O   . HOH R 6 .   ? -15.573 22.630  39.318 1.00 30.26 ? 1224 HOH A O   1 
HETATM 4043 O  O   . HOH R 6 .   ? 7.291   2.495   7.257  1.00 24.22 ? 1225 HOH A O   1 
HETATM 4044 O  O   . HOH R 6 .   ? -12.069 27.623  11.518 1.00 32.86 ? 1226 HOH A O   1 
HETATM 4045 O  O   . HOH R 6 .   ? -15.997 19.878  19.799 1.00 35.26 ? 1227 HOH A O   1 
HETATM 4046 O  O   . HOH R 6 .   ? -2.587  20.157  0.133  1.00 23.73 ? 1228 HOH A O   1 
HETATM 4047 O  O   . HOH R 6 .   ? -23.757 6.694   13.152 1.00 38.17 ? 1229 HOH A O   1 
HETATM 4048 O  O   . HOH R 6 .   ? -4.591  16.705  23.541 1.00 8.46  ? 1230 HOH A O   1 
HETATM 4049 O  O   . HOH R 6 .   ? -21.074 -9.105  30.185 1.00 27.18 ? 1231 HOH A O   1 
HETATM 4050 O  O   . HOH R 6 .   ? 11.440  15.794  41.298 1.00 22.65 ? 1232 HOH A O   1 
HETATM 4051 O  O   . HOH R 6 .   ? -8.153  22.418  -2.113 1.00 35.17 ? 1233 HOH A O   1 
HETATM 4052 O  O   . HOH R 6 .   ? -5.092  22.093  21.958 1.00 18.11 ? 1234 HOH A O   1 
HETATM 4053 O  O   . HOH R 6 .   ? 3.068   14.907  42.897 1.00 25.11 ? 1235 HOH A O   1 
HETATM 4054 O  O   . HOH R 6 .   ? -5.493  22.321  19.217 1.00 22.88 ? 1236 HOH A O   1 
HETATM 4055 O  O   . HOH R 6 .   ? -5.911  -1.334  41.400 1.00 12.34 ? 1237 HOH A O   1 
HETATM 4056 O  O   . HOH R 6 .   ? -19.544 12.595  27.001 1.00 23.66 ? 1238 HOH A O   1 
HETATM 4057 O  O   . HOH R 6 .   ? -5.834  -0.560  -0.291 1.00 36.55 ? 1239 HOH A O   1 
HETATM 4058 O  O   . HOH R 6 .   ? 13.969  -10.082 34.178 1.00 33.92 ? 1240 HOH A O   1 
HETATM 4059 O  O   . HOH R 6 .   ? 20.308  -15.079 29.381 1.00 28.20 ? 1241 HOH A O   1 
HETATM 4060 O  O   . HOH R 6 .   ? -0.381  26.459  12.441 1.00 32.89 ? 1242 HOH A O   1 
HETATM 4061 O  O   . HOH R 6 .   ? 7.740   -16.160 5.007  1.00 35.40 ? 1243 HOH A O   1 
HETATM 4062 O  O   . HOH R 6 .   ? 0.669   22.527  12.337 1.00 37.30 ? 1244 HOH A O   1 
HETATM 4063 O  O   . HOH R 6 .   ? -9.201  13.488  -2.917 1.00 38.28 ? 1245 HOH A O   1 
HETATM 4064 O  O   . HOH R 6 .   ? -18.348 -23.913 0.918  1.00 34.04 ? 1246 HOH A O   1 
HETATM 4065 O  O   . HOH R 6 .   ? -3.714  22.517  17.682 1.00 19.40 ? 1247 HOH A O   1 
HETATM 4066 O  O   . HOH R 6 .   ? 16.230  0.578   33.455 1.00 29.23 ? 1248 HOH A O   1 
HETATM 4067 O  O   . HOH R 6 .   ? 11.015  13.314  40.072 1.00 35.61 ? 1249 HOH A O   1 
HETATM 4068 O  O   . HOH R 6 .   ? -12.834 -0.932  0.958  0.50 28.47 ? 1250 HOH A O   1 
HETATM 4069 O  O   . HOH R 6 .   ? -17.417 26.722  9.719  1.00 25.24 ? 1251 HOH A O   1 
HETATM 4070 O  O   . HOH R 6 .   ? 1.369   -28.098 26.085 1.00 26.96 ? 1252 HOH A O   1 
HETATM 4071 O  O   . HOH R 6 .   ? -1.116  8.741   44.262 1.00 35.54 ? 1253 HOH A O   1 
HETATM 4072 O  O   . HOH R 6 .   ? -15.870 10.890  39.632 1.00 34.12 ? 1254 HOH A O   1 
HETATM 4073 O  O   . HOH R 6 .   ? 12.859  15.220  23.274 1.00 27.56 ? 1255 HOH A O   1 
HETATM 4074 O  O   . HOH R 6 .   ? -13.834 28.615  25.624 1.00 21.86 ? 1256 HOH A O   1 
HETATM 4075 O  O   . HOH R 6 .   ? -18.660 -15.275 31.657 1.00 29.39 ? 1257 HOH A O   1 
HETATM 4076 O  O   . HOH R 6 .   ? -3.475  23.005  -0.897 1.00 32.09 ? 1258 HOH A O   1 
HETATM 4077 O  O   . HOH R 6 .   ? -1.522  18.061  41.612 1.00 40.01 ? 1259 HOH A O   1 
HETATM 4078 O  O   . HOH R 6 .   ? -0.866  -20.781 28.930 1.00 11.56 ? 1260 HOH A O   1 
HETATM 4079 O  O   . HOH R 6 .   ? -10.049 -26.797 1.702  1.00 33.25 ? 1261 HOH A O   1 
HETATM 4080 O  O   . HOH R 6 .   ? 14.921  7.612   12.254 1.00 30.59 ? 1262 HOH A O   1 
HETATM 4081 O  O   . HOH R 6 .   ? -5.684  -11.836 -4.129 1.00 32.18 ? 1263 HOH A O   1 
HETATM 4082 O  O   . HOH R 6 .   ? -1.238  30.447  25.859 1.00 30.68 ? 1264 HOH A O   1 
HETATM 4083 O  O   . HOH R 6 .   ? -17.888 -25.490 17.288 1.00 27.77 ? 1265 HOH A O   1 
HETATM 4084 O  O   . HOH R 6 .   ? -24.520 25.754  -0.470 1.00 30.00 ? 1266 HOH A O   1 
HETATM 4085 O  O   . HOH R 6 .   ? -1.391  30.345  28.390 1.00 34.31 ? 1267 HOH A O   1 
HETATM 4086 O  O   . HOH R 6 .   ? 5.170   -26.927 23.579 1.00 29.42 ? 1268 HOH A O   1 
HETATM 4087 O  O   . HOH R 6 .   ? 7.722   21.930  29.248 1.00 28.89 ? 1269 HOH A O   1 
HETATM 4088 O  O   . HOH R 6 .   ? -17.356 5.718   33.551 1.00 34.97 ? 1270 HOH A O   1 
HETATM 4089 O  O   . HOH R 6 .   ? -18.542 30.232  0.297  1.00 39.32 ? 1271 HOH A O   1 
HETATM 4090 O  O   . HOH R 6 .   ? -13.854 27.074  32.261 1.00 13.75 ? 1272 HOH A O   1 
HETATM 4091 O  O   . HOH R 6 .   ? -0.028  -23.287 29.503 1.00 18.96 ? 1273 HOH A O   1 
HETATM 4092 O  O   . HOH R 6 .   ? -1.194  -19.539 31.392 1.00 23.87 ? 1274 HOH A O   1 
HETATM 4093 O  O   . HOH R 6 .   ? 2.769   24.102  13.034 1.00 34.74 ? 1275 HOH A O   1 
HETATM 4094 O  O   . HOH R 6 .   ? 2.644   -23.848 29.211 1.00 31.51 ? 1276 HOH A O   1 
# 
