data_9MIE
# 
_entry.id   9MIE 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MIE         pdb_00009mie 10.2210/pdb9mie/pdb 
WWPDB D_1000291044 ?            ?                   
EMDB  EMD-48288    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Additional map'  1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 1 
5 'Half map'        1 0 2025-02-26 2 
6 Image             1 0 2025-02-26 ? 
7 'Primary map'     1 0 2025-02-26 ? 
8 'Structure model' 1 1 2025-03-12 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'     
2 8 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' citation        
2 8 'Structure model' citation_author 
3 8 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 8 'Structure model' '_citation.journal_volume'          
2 8 'Structure model' '_citation.page_first'              
3 8 'Structure model' '_citation.page_last'               
4 8 'Structure model' '_citation_author.identifier_ORCID' 
5 8 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MIE 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Human NLRP3 complex with compound 2 in the closed hexamer' 
_pdbx_database_related.db_id          EMD-48288 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xiaodi.yu1981@gmail.com 
_pdbx_contact_author.name_first         Xiaodi 
_pdbx_contact_author.name_last          Yu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7520-0646 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mammoliti, O.'    1 ? 
'Carbajo, R.J.'    2 ? 
'Perez-Benito, L.' 3 ? 
'Yu, X.'           4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                4848 
_citation.page_last                 4887 
_citation.title                     
'Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c03108 
_citation.pdbx_database_id_PubMed   39932543 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mammoliti, O.'      1  ? 
primary 'Carbajo, R.'        2  ? 
primary 'Perez-Benito, L.'   3  ? 
primary 'Yu, X.'             4  ? 
primary 'Prieri, M.L.C.'     5  ? 
primary 'Bontempi, L.'       6  ? 
primary 'Embrechts, S.'      7  ? 
primary 'Paesmans, I.'       8  ? 
primary 'Bassi, M.'          9  ? 
primary 'Bhattacharya, A.'   10 ? 
primary 'Canellas, S.'       11 ? 
primary 'De Hoog, S.'        12 ? 
primary 'Demin, S.'          13 ? 
primary 'Gijsen, H.J.M.'     14 ? 
primary 'Hache, G.'          15 ? 
primary 'Jacobs, T.'         16 ? 
primary 'Jerhaoui, S.'       17 ? 
primary 'Leenaerts, J.'      18 ? 
primary 'Lutter, F.H.'       19 ? 
primary 'Mahieu, M.'         20 ? 
primary 'Matico, R.'         21 ? 
primary 'Miller, R.'         22 ? 
primary 'Oehlrich, D.'       23 ? 
primary 'Perrier, M.'        24 ? 
primary 'Ryabchuk, P.'       25 ? 
primary 'Schepens, W.'       26 ? 
primary 'Sharma, S.'         27 ? 
primary 'Somers, M.'         28 ? 
primary 'Suarez, J.'         29 ? 
primary 'Surkyn, M.'         30 ? 
primary 'Van Opdenbosch, N.' 31 ? 
primary 'Verhulst, T.'       32 ? 
primary 'Bottelbergs, A.'    33 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NACHT, LRR and PYD domains-containing protein 3' 118323.531 1 3.6.4.- ? ? ? 
2 non-polymer syn "ADENOSINE-5'-TRIPHOSPHATE" 507.181    1 ?       ? ? ? 
3 non-polymer syn 
'(2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl)-5-(trifluoromethyl)phenol' 392.418    
1 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_entity_poly.pdbx_strand_id                 C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "ADENOSINE-5'-TRIPHOSPHATE"                                                                                            ATP   
3 '(2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl)-5-(trifluoromethyl)phenol' A1BLP 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1    MET n 
1 2    LYS n 
1 3    MET n 
1 4    ALA n 
1 5    SER n 
1 6    THR n 
1 7    ARG n 
1 8    CYS n 
1 9    LYS n 
1 10   LEU n 
1 11   ALA n 
1 12   ARG n 
1 13   TYR n 
1 14   LEU n 
1 15   GLU n 
1 16   ASP n 
1 17   LEU n 
1 18   GLU n 
1 19   ASP n 
1 20   VAL n 
1 21   ASP n 
1 22   LEU n 
1 23   LYS n 
1 24   LYS n 
1 25   PHE n 
1 26   LYS n 
1 27   MET n 
1 28   HIS n 
1 29   LEU n 
1 30   GLU n 
1 31   ASP n 
1 32   TYR n 
1 33   PRO n 
1 34   PRO n 
1 35   GLN n 
1 36   LYS n 
1 37   GLY n 
1 38   CYS n 
1 39   ILE n 
1 40   PRO n 
1 41   LEU n 
1 42   PRO n 
1 43   ARG n 
1 44   GLY n 
1 45   GLN n 
1 46   THR n 
1 47   GLU n 
1 48   LYS n 
1 49   ALA n 
1 50   ASP n 
1 51   HIS n 
1 52   VAL n 
1 53   ASP n 
1 54   LEU n 
1 55   ALA n 
1 56   THR n 
1 57   LEU n 
1 58   MET n 
1 59   ILE n 
1 60   ASP n 
1 61   PHE n 
1 62   ASN n 
1 63   GLY n 
1 64   GLU n 
1 65   GLU n 
1 66   LYS n 
1 67   ALA n 
1 68   TRP n 
1 69   ALA n 
1 70   MET n 
1 71   ALA n 
1 72   VAL n 
1 73   TRP n 
1 74   ILE n 
1 75   PHE n 
1 76   ALA n 
1 77   ALA n 
1 78   ILE n 
1 79   ASN n 
1 80   ARG n 
1 81   ARG n 
1 82   ASP n 
1 83   LEU n 
1 84   TYR n 
1 85   GLU n 
1 86   LYS n 
1 87   ALA n 
1 88   LYS n 
1 89   ARG n 
1 90   ASP n 
1 91   GLU n 
1 92   PRO n 
1 93   LYS n 
1 94   TRP n 
1 95   GLY n 
1 96   SER n 
1 97   ASP n 
1 98   ASN n 
1 99   ALA n 
1 100  ARG n 
1 101  VAL n 
1 102  SER n 
1 103  ASN n 
1 104  PRO n 
1 105  THR n 
1 106  VAL n 
1 107  ILE n 
1 108  CYS n 
1 109  GLN n 
1 110  GLU n 
1 111  ASP n 
1 112  SER n 
1 113  ILE n 
1 114  GLU n 
1 115  GLU n 
1 116  GLU n 
1 117  TRP n 
1 118  MET n 
1 119  GLY n 
1 120  LEU n 
1 121  LEU n 
1 122  GLU n 
1 123  TYR n 
1 124  LEU n 
1 125  SER n 
1 126  ARG n 
1 127  ILE n 
1 128  SER n 
1 129  ILE n 
1 130  CYS n 
1 131  LYS n 
1 132  MET n 
1 133  LYS n 
1 134  LYS n 
1 135  ASP n 
1 136  TYR n 
1 137  ARG n 
1 138  LYS n 
1 139  LYS n 
1 140  TYR n 
1 141  ARG n 
1 142  LYS n 
1 143  TYR n 
1 144  VAL n 
1 145  ARG n 
1 146  SER n 
1 147  ARG n 
1 148  PHE n 
1 149  GLN n 
1 150  CYS n 
1 151  ILE n 
1 152  GLU n 
1 153  ASP n 
1 154  ARG n 
1 155  ASN n 
1 156  ALA n 
1 157  ARG n 
1 158  LEU n 
1 159  GLY n 
1 160  GLU n 
1 161  SER n 
1 162  VAL n 
1 163  SER n 
1 164  LEU n 
1 165  ASN n 
1 166  LYS n 
1 167  ARG n 
1 168  TYR n 
1 169  THR n 
1 170  ARG n 
1 171  LEU n 
1 172  ARG n 
1 173  LEU n 
1 174  ILE n 
1 175  LYS n 
1 176  GLU n 
1 177  HIS n 
1 178  ARG n 
1 179  SER n 
1 180  GLN n 
1 181  GLN n 
1 182  GLU n 
1 183  ARG n 
1 184  GLU n 
1 185  GLN n 
1 186  GLU n 
1 187  LEU n 
1 188  LEU n 
1 189  ALA n 
1 190  ILE n 
1 191  GLY n 
1 192  LYS n 
1 193  THR n 
1 194  LYS n 
1 195  THR n 
1 196  CYS n 
1 197  GLU n 
1 198  SER n 
1 199  PRO n 
1 200  VAL n 
1 201  SER n 
1 202  PRO n 
1 203  ILE n 
1 204  LYS n 
1 205  MET n 
1 206  GLU n 
1 207  LEU n 
1 208  LEU n 
1 209  PHE n 
1 210  ASP n 
1 211  PRO n 
1 212  ASP n 
1 213  ASP n 
1 214  GLU n 
1 215  HIS n 
1 216  SER n 
1 217  GLU n 
1 218  PRO n 
1 219  VAL n 
1 220  HIS n 
1 221  THR n 
1 222  VAL n 
1 223  VAL n 
1 224  PHE n 
1 225  GLN n 
1 226  GLY n 
1 227  ALA n 
1 228  ALA n 
1 229  GLY n 
1 230  ILE n 
1 231  GLY n 
1 232  LYS n 
1 233  THR n 
1 234  ILE n 
1 235  LEU n 
1 236  ALA n 
1 237  ARG n 
1 238  LYS n 
1 239  MET n 
1 240  MET n 
1 241  LEU n 
1 242  ASP n 
1 243  TRP n 
1 244  ALA n 
1 245  SER n 
1 246  GLY n 
1 247  THR n 
1 248  LEU n 
1 249  TYR n 
1 250  GLN n 
1 251  ASP n 
1 252  ARG n 
1 253  PHE n 
1 254  ASP n 
1 255  TYR n 
1 256  LEU n 
1 257  PHE n 
1 258  TYR n 
1 259  ILE n 
1 260  HIS n 
1 261  CYS n 
1 262  ARG n 
1 263  GLU n 
1 264  VAL n 
1 265  SER n 
1 266  LEU n 
1 267  VAL n 
1 268  THR n 
1 269  GLN n 
1 270  ARG n 
1 271  SER n 
1 272  LEU n 
1 273  GLY n 
1 274  ASP n 
1 275  LEU n 
1 276  ILE n 
1 277  MET n 
1 278  SER n 
1 279  CYS n 
1 280  CYS n 
1 281  PRO n 
1 282  ASP n 
1 283  PRO n 
1 284  ASN n 
1 285  PRO n 
1 286  PRO n 
1 287  ILE n 
1 288  HIS n 
1 289  LYS n 
1 290  ILE n 
1 291  VAL n 
1 292  ARG n 
1 293  LYS n 
1 294  PRO n 
1 295  SER n 
1 296  ARG n 
1 297  ILE n 
1 298  LEU n 
1 299  PHE n 
1 300  LEU n 
1 301  MET n 
1 302  ASP n 
1 303  GLY n 
1 304  PHE n 
1 305  ASP n 
1 306  GLU n 
1 307  LEU n 
1 308  GLN n 
1 309  GLY n 
1 310  ALA n 
1 311  PHE n 
1 312  ASP n 
1 313  GLU n 
1 314  HIS n 
1 315  ILE n 
1 316  GLY n 
1 317  PRO n 
1 318  LEU n 
1 319  CYS n 
1 320  THR n 
1 321  ASP n 
1 322  TRP n 
1 323  GLN n 
1 324  LYS n 
1 325  ALA n 
1 326  GLU n 
1 327  ARG n 
1 328  GLY n 
1 329  ASP n 
1 330  ILE n 
1 331  LEU n 
1 332  LEU n 
1 333  SER n 
1 334  SER n 
1 335  LEU n 
1 336  ILE n 
1 337  ARG n 
1 338  LYS n 
1 339  LYS n 
1 340  LEU n 
1 341  LEU n 
1 342  PRO n 
1 343  GLU n 
1 344  ALA n 
1 345  SER n 
1 346  LEU n 
1 347  LEU n 
1 348  ILE n 
1 349  THR n 
1 350  THR n 
1 351  ARG n 
1 352  PRO n 
1 353  VAL n 
1 354  ALA n 
1 355  LEU n 
1 356  GLU n 
1 357  LYS n 
1 358  LEU n 
1 359  GLN n 
1 360  HIS n 
1 361  LEU n 
1 362  LEU n 
1 363  ASP n 
1 364  HIS n 
1 365  PRO n 
1 366  ARG n 
1 367  HIS n 
1 368  VAL n 
1 369  GLU n 
1 370  ILE n 
1 371  LEU n 
1 372  GLY n 
1 373  PHE n 
1 374  SER n 
1 375  GLU n 
1 376  ALA n 
1 377  LYS n 
1 378  ARG n 
1 379  LYS n 
1 380  GLU n 
1 381  TYR n 
1 382  PHE n 
1 383  PHE n 
1 384  LYS n 
1 385  TYR n 
1 386  PHE n 
1 387  SER n 
1 388  ASP n 
1 389  GLU n 
1 390  ALA n 
1 391  GLN n 
1 392  ALA n 
1 393  ARG n 
1 394  ALA n 
1 395  ALA n 
1 396  PHE n 
1 397  SER n 
1 398  LEU n 
1 399  ILE n 
1 400  GLN n 
1 401  GLU n 
1 402  ASN n 
1 403  GLU n 
1 404  VAL n 
1 405  LEU n 
1 406  PHE n 
1 407  THR n 
1 408  MET n 
1 409  CYS n 
1 410  PHE n 
1 411  ILE n 
1 412  PRO n 
1 413  LEU n 
1 414  VAL n 
1 415  CYS n 
1 416  TRP n 
1 417  ILE n 
1 418  VAL n 
1 419  CYS n 
1 420  THR n 
1 421  GLY n 
1 422  LEU n 
1 423  LYS n 
1 424  GLN n 
1 425  GLN n 
1 426  MET n 
1 427  GLU n 
1 428  SER n 
1 429  GLY n 
1 430  LYS n 
1 431  SER n 
1 432  LEU n 
1 433  ALA n 
1 434  GLN n 
1 435  THR n 
1 436  SER n 
1 437  LYS n 
1 438  THR n 
1 439  THR n 
1 440  THR n 
1 441  ALA n 
1 442  VAL n 
1 443  TYR n 
1 444  VAL n 
1 445  PHE n 
1 446  PHE n 
1 447  LEU n 
1 448  SER n 
1 449  SER n 
1 450  LEU n 
1 451  LEU n 
1 452  GLN n 
1 453  PRO n 
1 454  ARG n 
1 455  GLY n 
1 456  GLY n 
1 457  SER n 
1 458  GLN n 
1 459  GLU n 
1 460  HIS n 
1 461  GLY n 
1 462  LEU n 
1 463  CYS n 
1 464  ALA n 
1 465  HIS n 
1 466  LEU n 
1 467  TRP n 
1 468  GLY n 
1 469  LEU n 
1 470  CYS n 
1 471  SER n 
1 472  LEU n 
1 473  ALA n 
1 474  ALA n 
1 475  ASP n 
1 476  GLY n 
1 477  ILE n 
1 478  TRP n 
1 479  ASN n 
1 480  GLN n 
1 481  LYS n 
1 482  ILE n 
1 483  LEU n 
1 484  PHE n 
1 485  GLU n 
1 486  GLU n 
1 487  SER n 
1 488  ASP n 
1 489  LEU n 
1 490  ARG n 
1 491  ASN n 
1 492  HIS n 
1 493  GLY n 
1 494  LEU n 
1 495  GLN n 
1 496  LYS n 
1 497  ALA n 
1 498  ASP n 
1 499  VAL n 
1 500  SER n 
1 501  ALA n 
1 502  PHE n 
1 503  LEU n 
1 504  ARG n 
1 505  MET n 
1 506  ASN n 
1 507  LEU n 
1 508  PHE n 
1 509  GLN n 
1 510  LYS n 
1 511  GLU n 
1 512  VAL n 
1 513  ASP n 
1 514  CYS n 
1 515  GLU n 
1 516  LYS n 
1 517  PHE n 
1 518  TYR n 
1 519  SER n 
1 520  PHE n 
1 521  ILE n 
1 522  HIS n 
1 523  MET n 
1 524  THR n 
1 525  PHE n 
1 526  GLN n 
1 527  GLU n 
1 528  PHE n 
1 529  PHE n 
1 530  ALA n 
1 531  ALA n 
1 532  MET n 
1 533  TYR n 
1 534  TYR n 
1 535  LEU n 
1 536  LEU n 
1 537  GLU n 
1 538  GLU n 
1 539  GLU n 
1 540  LYS n 
1 541  GLU n 
1 542  GLY n 
1 543  ARG n 
1 544  THR n 
1 545  ASN n 
1 546  VAL n 
1 547  PRO n 
1 548  GLY n 
1 549  SER n 
1 550  ARG n 
1 551  LEU n 
1 552  LYS n 
1 553  LEU n 
1 554  PRO n 
1 555  SER n 
1 556  ARG n 
1 557  ASP n 
1 558  VAL n 
1 559  THR n 
1 560  VAL n 
1 561  LEU n 
1 562  LEU n 
1 563  GLU n 
1 564  ASN n 
1 565  TYR n 
1 566  GLY n 
1 567  LYS n 
1 568  PHE n 
1 569  GLU n 
1 570  LYS n 
1 571  GLY n 
1 572  TYR n 
1 573  LEU n 
1 574  ILE n 
1 575  PHE n 
1 576  VAL n 
1 577  VAL n 
1 578  ARG n 
1 579  PHE n 
1 580  LEU n 
1 581  PHE n 
1 582  GLY n 
1 583  LEU n 
1 584  VAL n 
1 585  ASN n 
1 586  GLN n 
1 587  GLU n 
1 588  ARG n 
1 589  THR n 
1 590  SER n 
1 591  TYR n 
1 592  LEU n 
1 593  GLU n 
1 594  LYS n 
1 595  LYS n 
1 596  LEU n 
1 597  SER n 
1 598  CYS n 
1 599  LYS n 
1 600  ILE n 
1 601  SER n 
1 602  GLN n 
1 603  GLN n 
1 604  ILE n 
1 605  ARG n 
1 606  LEU n 
1 607  GLU n 
1 608  LEU n 
1 609  LEU n 
1 610  LYS n 
1 611  TRP n 
1 612  ILE n 
1 613  GLU n 
1 614  VAL n 
1 615  LYS n 
1 616  ALA n 
1 617  LYS n 
1 618  ALA n 
1 619  LYS n 
1 620  LYS n 
1 621  LEU n 
1 622  GLN n 
1 623  ILE n 
1 624  GLN n 
1 625  PRO n 
1 626  SER n 
1 627  GLN n 
1 628  LEU n 
1 629  GLU n 
1 630  LEU n 
1 631  PHE n 
1 632  TYR n 
1 633  CYS n 
1 634  LEU n 
1 635  TYR n 
1 636  GLU n 
1 637  MET n 
1 638  GLN n 
1 639  GLU n 
1 640  GLU n 
1 641  ASP n 
1 642  PHE n 
1 643  VAL n 
1 644  GLN n 
1 645  ARG n 
1 646  ALA n 
1 647  MET n 
1 648  ASP n 
1 649  TYR n 
1 650  PHE n 
1 651  PRO n 
1 652  LYS n 
1 653  ILE n 
1 654  GLU n 
1 655  ILE n 
1 656  ASN n 
1 657  LEU n 
1 658  SER n 
1 659  THR n 
1 660  ARG n 
1 661  MET n 
1 662  ASP n 
1 663  HIS n 
1 664  MET n 
1 665  VAL n 
1 666  SER n 
1 667  SER n 
1 668  PHE n 
1 669  CYS n 
1 670  ILE n 
1 671  GLU n 
1 672  ASN n 
1 673  CYS n 
1 674  HIS n 
1 675  ARG n 
1 676  VAL n 
1 677  GLU n 
1 678  SER n 
1 679  LEU n 
1 680  SER n 
1 681  LEU n 
1 682  GLY n 
1 683  PHE n 
1 684  LEU n 
1 685  HIS n 
1 686  ASN n 
1 687  MET n 
1 688  PRO n 
1 689  LYS n 
1 690  GLU n 
1 691  GLU n 
1 692  GLU n 
1 693  GLU n 
1 694  GLU n 
1 695  GLU n 
1 696  LYS n 
1 697  GLU n 
1 698  GLY n 
1 699  ARG n 
1 700  HIS n 
1 701  LEU n 
1 702  ASP n 
1 703  MET n 
1 704  VAL n 
1 705  GLN n 
1 706  CYS n 
1 707  VAL n 
1 708  LEU n 
1 709  PRO n 
1 710  SER n 
1 711  SER n 
1 712  SER n 
1 713  HIS n 
1 714  ALA n 
1 715  ALA n 
1 716  CYS n 
1 717  SER n 
1 718  HIS n 
1 719  GLY n 
1 720  LEU n 
1 721  VAL n 
1 722  ASN n 
1 723  SER n 
1 724  HIS n 
1 725  LEU n 
1 726  THR n 
1 727  SER n 
1 728  SER n 
1 729  PHE n 
1 730  CYS n 
1 731  ARG n 
1 732  GLY n 
1 733  LEU n 
1 734  PHE n 
1 735  SER n 
1 736  VAL n 
1 737  LEU n 
1 738  SER n 
1 739  THR n 
1 740  SER n 
1 741  GLN n 
1 742  SER n 
1 743  LEU n 
1 744  THR n 
1 745  GLU n 
1 746  LEU n 
1 747  ASP n 
1 748  LEU n 
1 749  SER n 
1 750  ASP n 
1 751  ASN n 
1 752  SER n 
1 753  LEU n 
1 754  GLY n 
1 755  ASP n 
1 756  PRO n 
1 757  GLY n 
1 758  MET n 
1 759  ARG n 
1 760  VAL n 
1 761  LEU n 
1 762  CYS n 
1 763  GLU n 
1 764  THR n 
1 765  LEU n 
1 766  GLN n 
1 767  HIS n 
1 768  PRO n 
1 769  GLY n 
1 770  CYS n 
1 771  ASN n 
1 772  ILE n 
1 773  ARG n 
1 774  ARG n 
1 775  LEU n 
1 776  TRP n 
1 777  LEU n 
1 778  GLY n 
1 779  ARG n 
1 780  CYS n 
1 781  GLY n 
1 782  LEU n 
1 783  SER n 
1 784  HIS n 
1 785  GLU n 
1 786  CYS n 
1 787  CYS n 
1 788  PHE n 
1 789  ASP n 
1 790  ILE n 
1 791  SER n 
1 792  LEU n 
1 793  VAL n 
1 794  LEU n 
1 795  SER n 
1 796  SER n 
1 797  ASN n 
1 798  GLN n 
1 799  LYS n 
1 800  LEU n 
1 801  VAL n 
1 802  GLU n 
1 803  LEU n 
1 804  ASP n 
1 805  LEU n 
1 806  SER n 
1 807  ASP n 
1 808  ASN n 
1 809  ALA n 
1 810  LEU n 
1 811  GLY n 
1 812  ASP n 
1 813  PHE n 
1 814  GLY n 
1 815  ILE n 
1 816  ARG n 
1 817  LEU n 
1 818  LEU n 
1 819  CYS n 
1 820  VAL n 
1 821  GLY n 
1 822  LEU n 
1 823  LYS n 
1 824  HIS n 
1 825  LEU n 
1 826  LEU n 
1 827  CYS n 
1 828  ASN n 
1 829  LEU n 
1 830  LYS n 
1 831  LYS n 
1 832  LEU n 
1 833  TRP n 
1 834  LEU n 
1 835  VAL n 
1 836  SER n 
1 837  CYS n 
1 838  CYS n 
1 839  LEU n 
1 840  THR n 
1 841  SER n 
1 842  ALA n 
1 843  CYS n 
1 844  CYS n 
1 845  GLN n 
1 846  ASP n 
1 847  LEU n 
1 848  ALA n 
1 849  SER n 
1 850  VAL n 
1 851  LEU n 
1 852  SER n 
1 853  THR n 
1 854  SER n 
1 855  HIS n 
1 856  SER n 
1 857  LEU n 
1 858  THR n 
1 859  ARG n 
1 860  LEU n 
1 861  TYR n 
1 862  VAL n 
1 863  GLY n 
1 864  GLU n 
1 865  ASN n 
1 866  ALA n 
1 867  LEU n 
1 868  GLY n 
1 869  ASP n 
1 870  SER n 
1 871  GLY n 
1 872  VAL n 
1 873  ALA n 
1 874  ILE n 
1 875  LEU n 
1 876  CYS n 
1 877  GLU n 
1 878  LYS n 
1 879  ALA n 
1 880  LYS n 
1 881  ASN n 
1 882  PRO n 
1 883  GLN n 
1 884  CYS n 
1 885  ASN n 
1 886  LEU n 
1 887  GLN n 
1 888  LYS n 
1 889  LEU n 
1 890  GLY n 
1 891  LEU n 
1 892  VAL n 
1 893  ASN n 
1 894  SER n 
1 895  GLY n 
1 896  LEU n 
1 897  THR n 
1 898  SER n 
1 899  VAL n 
1 900  CYS n 
1 901  CYS n 
1 902  SER n 
1 903  ALA n 
1 904  LEU n 
1 905  SER n 
1 906  SER n 
1 907  VAL n 
1 908  LEU n 
1 909  SER n 
1 910  THR n 
1 911  ASN n 
1 912  GLN n 
1 913  ASN n 
1 914  LEU n 
1 915  THR n 
1 916  HIS n 
1 917  LEU n 
1 918  TYR n 
1 919  LEU n 
1 920  ARG n 
1 921  GLY n 
1 922  ASN n 
1 923  THR n 
1 924  LEU n 
1 925  GLY n 
1 926  ASP n 
1 927  LYS n 
1 928  GLY n 
1 929  ILE n 
1 930  LYS n 
1 931  LEU n 
1 932  LEU n 
1 933  CYS n 
1 934  GLU n 
1 935  GLY n 
1 936  LEU n 
1 937  LEU n 
1 938  HIS n 
1 939  PRO n 
1 940  ASP n 
1 941  CYS n 
1 942  LYS n 
1 943  LEU n 
1 944  GLN n 
1 945  VAL n 
1 946  LEU n 
1 947  GLU n 
1 948  LEU n 
1 949  ASP n 
1 950  ASN n 
1 951  CYS n 
1 952  ASN n 
1 953  LEU n 
1 954  THR n 
1 955  SER n 
1 956  HIS n 
1 957  CYS n 
1 958  CYS n 
1 959  TRP n 
1 960  ASP n 
1 961  LEU n 
1 962  SER n 
1 963  THR n 
1 964  LEU n 
1 965  LEU n 
1 966  THR n 
1 967  SER n 
1 968  SER n 
1 969  GLN n 
1 970  SER n 
1 971  LEU n 
1 972  ARG n 
1 973  LYS n 
1 974  LEU n 
1 975  SER n 
1 976  LEU n 
1 977  GLY n 
1 978  ASN n 
1 979  ASN n 
1 980  ASP n 
1 981  LEU n 
1 982  GLY n 
1 983  ASP n 
1 984  LEU n 
1 985  GLY n 
1 986  VAL n 
1 987  MET n 
1 988  MET n 
1 989  PHE n 
1 990  CYS n 
1 991  GLU n 
1 992  VAL n 
1 993  LEU n 
1 994  LYS n 
1 995  GLN n 
1 996  GLN n 
1 997  SER n 
1 998  CYS n 
1 999  LEU n 
1 1000 LEU n 
1 1001 GLN n 
1 1002 ASN n 
1 1003 LEU n 
1 1004 GLY n 
1 1005 LEU n 
1 1006 SER n 
1 1007 GLU n 
1 1008 MET n 
1 1009 TYR n 
1 1010 PHE n 
1 1011 ASN n 
1 1012 TYR n 
1 1013 GLU n 
1 1014 THR n 
1 1015 LYS n 
1 1016 SER n 
1 1017 ALA n 
1 1018 LEU n 
1 1019 GLU n 
1 1020 THR n 
1 1021 LEU n 
1 1022 GLN n 
1 1023 GLU n 
1 1024 GLU n 
1 1025 LYS n 
1 1026 PRO n 
1 1027 GLU n 
1 1028 LEU n 
1 1029 THR n 
1 1030 VAL n 
1 1031 VAL n 
1 1032 PHE n 
1 1033 GLU n 
1 1034 PRO n 
1 1035 SER n 
1 1036 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   1036 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'NLRP3, C1orf7, CIAS1, NALP3, PYPAF1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BLP non-polymer         . 
'(2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl)-5-(trifluoromethyl)phenol' ? 
'C20 H23 F3 N4 O'   392.418 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'        89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'    175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'       132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'        133.103 
ATP   non-polymer         . "ADENOSINE-5'-TRIPHOSPHATE" ? 'C10 H16 N5 O13 P3' 507.181 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'      121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'      146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'        147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'        75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'    156.162 
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'       131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'       131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'    147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'     149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'       165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'        115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'        105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'        119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'     204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'       181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1    MET 1    1    ?    ?   ?   C . n 
A 1 2    LYS 2    2    ?    ?   ?   C . n 
A 1 3    MET 3    3    ?    ?   ?   C . n 
A 1 4    ALA 4    4    ?    ?   ?   C . n 
A 1 5    SER 5    5    ?    ?   ?   C . n 
A 1 6    THR 6    6    ?    ?   ?   C . n 
A 1 7    ARG 7    7    ?    ?   ?   C . n 
A 1 8    CYS 8    8    ?    ?   ?   C . n 
A 1 9    LYS 9    9    ?    ?   ?   C . n 
A 1 10   LEU 10   10   ?    ?   ?   C . n 
A 1 11   ALA 11   11   ?    ?   ?   C . n 
A 1 12   ARG 12   12   ?    ?   ?   C . n 
A 1 13   TYR 13   13   ?    ?   ?   C . n 
A 1 14   LEU 14   14   ?    ?   ?   C . n 
A 1 15   GLU 15   15   ?    ?   ?   C . n 
A 1 16   ASP 16   16   ?    ?   ?   C . n 
A 1 17   LEU 17   17   ?    ?   ?   C . n 
A 1 18   GLU 18   18   ?    ?   ?   C . n 
A 1 19   ASP 19   19   ?    ?   ?   C . n 
A 1 20   VAL 20   20   ?    ?   ?   C . n 
A 1 21   ASP 21   21   ?    ?   ?   C . n 
A 1 22   LEU 22   22   ?    ?   ?   C . n 
A 1 23   LYS 23   23   ?    ?   ?   C . n 
A 1 24   LYS 24   24   ?    ?   ?   C . n 
A 1 25   PHE 25   25   ?    ?   ?   C . n 
A 1 26   LYS 26   26   ?    ?   ?   C . n 
A 1 27   MET 27   27   ?    ?   ?   C . n 
A 1 28   HIS 28   28   ?    ?   ?   C . n 
A 1 29   LEU 29   29   ?    ?   ?   C . n 
A 1 30   GLU 30   30   ?    ?   ?   C . n 
A 1 31   ASP 31   31   ?    ?   ?   C . n 
A 1 32   TYR 32   32   ?    ?   ?   C . n 
A 1 33   PRO 33   33   ?    ?   ?   C . n 
A 1 34   PRO 34   34   ?    ?   ?   C . n 
A 1 35   GLN 35   35   ?    ?   ?   C . n 
A 1 36   LYS 36   36   ?    ?   ?   C . n 
A 1 37   GLY 37   37   ?    ?   ?   C . n 
A 1 38   CYS 38   38   ?    ?   ?   C . n 
A 1 39   ILE 39   39   ?    ?   ?   C . n 
A 1 40   PRO 40   40   ?    ?   ?   C . n 
A 1 41   LEU 41   41   ?    ?   ?   C . n 
A 1 42   PRO 42   42   ?    ?   ?   C . n 
A 1 43   ARG 43   43   ?    ?   ?   C . n 
A 1 44   GLY 44   44   ?    ?   ?   C . n 
A 1 45   GLN 45   45   ?    ?   ?   C . n 
A 1 46   THR 46   46   ?    ?   ?   C . n 
A 1 47   GLU 47   47   ?    ?   ?   C . n 
A 1 48   LYS 48   48   ?    ?   ?   C . n 
A 1 49   ALA 49   49   ?    ?   ?   C . n 
A 1 50   ASP 50   50   ?    ?   ?   C . n 
A 1 51   HIS 51   51   ?    ?   ?   C . n 
A 1 52   VAL 52   52   ?    ?   ?   C . n 
A 1 53   ASP 53   53   ?    ?   ?   C . n 
A 1 54   LEU 54   54   ?    ?   ?   C . n 
A 1 55   ALA 55   55   ?    ?   ?   C . n 
A 1 56   THR 56   56   ?    ?   ?   C . n 
A 1 57   LEU 57   57   ?    ?   ?   C . n 
A 1 58   MET 58   58   ?    ?   ?   C . n 
A 1 59   ILE 59   59   ?    ?   ?   C . n 
A 1 60   ASP 60   60   ?    ?   ?   C . n 
A 1 61   PHE 61   61   ?    ?   ?   C . n 
A 1 62   ASN 62   62   ?    ?   ?   C . n 
A 1 63   GLY 63   63   ?    ?   ?   C . n 
A 1 64   GLU 64   64   ?    ?   ?   C . n 
A 1 65   GLU 65   65   ?    ?   ?   C . n 
A 1 66   LYS 66   66   ?    ?   ?   C . n 
A 1 67   ALA 67   67   ?    ?   ?   C . n 
A 1 68   TRP 68   68   ?    ?   ?   C . n 
A 1 69   ALA 69   69   ?    ?   ?   C . n 
A 1 70   MET 70   70   ?    ?   ?   C . n 
A 1 71   ALA 71   71   ?    ?   ?   C . n 
A 1 72   VAL 72   72   ?    ?   ?   C . n 
A 1 73   TRP 73   73   ?    ?   ?   C . n 
A 1 74   ILE 74   74   ?    ?   ?   C . n 
A 1 75   PHE 75   75   ?    ?   ?   C . n 
A 1 76   ALA 76   76   ?    ?   ?   C . n 
A 1 77   ALA 77   77   ?    ?   ?   C . n 
A 1 78   ILE 78   78   ?    ?   ?   C . n 
A 1 79   ASN 79   79   ?    ?   ?   C . n 
A 1 80   ARG 80   80   ?    ?   ?   C . n 
A 1 81   ARG 81   81   ?    ?   ?   C . n 
A 1 82   ASP 82   82   ?    ?   ?   C . n 
A 1 83   LEU 83   83   ?    ?   ?   C . n 
A 1 84   TYR 84   84   ?    ?   ?   C . n 
A 1 85   GLU 85   85   ?    ?   ?   C . n 
A 1 86   LYS 86   86   ?    ?   ?   C . n 
A 1 87   ALA 87   87   ?    ?   ?   C . n 
A 1 88   LYS 88   88   ?    ?   ?   C . n 
A 1 89   ARG 89   89   ?    ?   ?   C . n 
A 1 90   ASP 90   90   ?    ?   ?   C . n 
A 1 91   GLU 91   91   ?    ?   ?   C . n 
A 1 92   PRO 92   92   ?    ?   ?   C . n 
A 1 93   LYS 93   93   ?    ?   ?   C . n 
A 1 94   TRP 94   94   ?    ?   ?   C . n 
A 1 95   GLY 95   95   ?    ?   ?   C . n 
A 1 96   SER 96   96   ?    ?   ?   C . n 
A 1 97   ASP 97   97   ?    ?   ?   C . n 
A 1 98   ASN 98   98   ?    ?   ?   C . n 
A 1 99   ALA 99   99   ?    ?   ?   C . n 
A 1 100  ARG 100  100  ?    ?   ?   C . n 
A 1 101  VAL 101  101  ?    ?   ?   C . n 
A 1 102  SER 102  102  ?    ?   ?   C . n 
A 1 103  ASN 103  103  ?    ?   ?   C . n 
A 1 104  PRO 104  104  ?    ?   ?   C . n 
A 1 105  THR 105  105  ?    ?   ?   C . n 
A 1 106  VAL 106  106  ?    ?   ?   C . n 
A 1 107  ILE 107  107  ?    ?   ?   C . n 
A 1 108  CYS 108  108  ?    ?   ?   C . n 
A 1 109  GLN 109  109  ?    ?   ?   C . n 
A 1 110  GLU 110  110  ?    ?   ?   C . n 
A 1 111  ASP 111  111  ?    ?   ?   C . n 
A 1 112  SER 112  112  ?    ?   ?   C . n 
A 1 113  ILE 113  113  ?    ?   ?   C . n 
A 1 114  GLU 114  114  ?    ?   ?   C . n 
A 1 115  GLU 115  115  ?    ?   ?   C . n 
A 1 116  GLU 116  116  ?    ?   ?   C . n 
A 1 117  TRP 117  117  ?    ?   ?   C . n 
A 1 118  MET 118  118  ?    ?   ?   C . n 
A 1 119  GLY 119  119  ?    ?   ?   C . n 
A 1 120  LEU 120  120  ?    ?   ?   C . n 
A 1 121  LEU 121  121  ?    ?   ?   C . n 
A 1 122  GLU 122  122  ?    ?   ?   C . n 
A 1 123  TYR 123  123  ?    ?   ?   C . n 
A 1 124  LEU 124  124  ?    ?   ?   C . n 
A 1 125  SER 125  125  ?    ?   ?   C . n 
A 1 126  ARG 126  126  ?    ?   ?   C . n 
A 1 127  ILE 127  127  ?    ?   ?   C . n 
A 1 128  SER 128  128  ?    ?   ?   C . n 
A 1 129  ILE 129  129  ?    ?   ?   C . n 
A 1 130  CYS 130  130  ?    ?   ?   C . n 
A 1 131  LYS 131  131  ?    ?   ?   C . n 
A 1 132  MET 132  132  ?    ?   ?   C . n 
A 1 133  LYS 133  133  133  LYS LYS C . n 
A 1 134  LYS 134  134  134  LYS LYS C . n 
A 1 135  ASP 135  135  135  ASP ASP C . n 
A 1 136  TYR 136  136  136  TYR TYR C . n 
A 1 137  ARG 137  137  137  ARG ARG C . n 
A 1 138  LYS 138  138  138  LYS LYS C . n 
A 1 139  LYS 139  139  139  LYS LYS C . n 
A 1 140  TYR 140  140  140  TYR TYR C . n 
A 1 141  ARG 141  141  141  ARG ARG C . n 
A 1 142  LYS 142  142  142  LYS LYS C . n 
A 1 143  TYR 143  143  143  TYR TYR C . n 
A 1 144  VAL 144  144  144  VAL VAL C . n 
A 1 145  ARG 145  145  145  ARG ARG C . n 
A 1 146  SER 146  146  146  SER SER C . n 
A 1 147  ARG 147  147  147  ARG ARG C . n 
A 1 148  PHE 148  148  148  PHE PHE C . n 
A 1 149  GLN 149  149  149  GLN GLN C . n 
A 1 150  CYS 150  150  150  CYS CYS C . n 
A 1 151  ILE 151  151  151  ILE ILE C . n 
A 1 152  GLU 152  152  152  GLU GLU C . n 
A 1 153  ASP 153  153  153  ASP ASP C . n 
A 1 154  ARG 154  154  154  ARG ARG C . n 
A 1 155  ASN 155  155  155  ASN ASN C . n 
A 1 156  ALA 156  156  156  ALA ALA C . n 
A 1 157  ARG 157  157  157  ARG ARG C . n 
A 1 158  LEU 158  158  158  LEU LEU C . n 
A 1 159  GLY 159  159  159  GLY GLY C . n 
A 1 160  GLU 160  160  160  GLU GLU C . n 
A 1 161  SER 161  161  161  SER SER C . n 
A 1 162  VAL 162  162  162  VAL VAL C . n 
A 1 163  SER 163  163  163  SER SER C . n 
A 1 164  LEU 164  164  164  LEU LEU C . n 
A 1 165  ASN 165  165  165  ASN ASN C . n 
A 1 166  LYS 166  166  166  LYS LYS C . n 
A 1 167  ARG 167  167  167  ARG ARG C . n 
A 1 168  TYR 168  168  168  TYR TYR C . n 
A 1 169  THR 169  169  169  THR THR C . n 
A 1 170  ARG 170  170  170  ARG ARG C . n 
A 1 171  LEU 171  171  171  LEU LEU C . n 
A 1 172  ARG 172  172  172  ARG ARG C . n 
A 1 173  LEU 173  173  173  LEU LEU C . n 
A 1 174  ILE 174  174  174  ILE ILE C . n 
A 1 175  LYS 175  175  175  LYS LYS C . n 
A 1 176  GLU 176  176  176  GLU GLU C . n 
A 1 177  HIS 177  177  ?    ?   ?   C . n 
A 1 178  ARG 178  178  ?    ?   ?   C . n 
A 1 179  SER 179  179  ?    ?   ?   C . n 
A 1 180  GLN 180  180  ?    ?   ?   C . n 
A 1 181  GLN 181  181  ?    ?   ?   C . n 
A 1 182  GLU 182  182  ?    ?   ?   C . n 
A 1 183  ARG 183  183  ?    ?   ?   C . n 
A 1 184  GLU 184  184  ?    ?   ?   C . n 
A 1 185  GLN 185  185  ?    ?   ?   C . n 
A 1 186  GLU 186  186  ?    ?   ?   C . n 
A 1 187  LEU 187  187  ?    ?   ?   C . n 
A 1 188  LEU 188  188  ?    ?   ?   C . n 
A 1 189  ALA 189  189  ?    ?   ?   C . n 
A 1 190  ILE 190  190  ?    ?   ?   C . n 
A 1 191  GLY 191  191  ?    ?   ?   C . n 
A 1 192  LYS 192  192  ?    ?   ?   C . n 
A 1 193  THR 193  193  ?    ?   ?   C . n 
A 1 194  LYS 194  194  ?    ?   ?   C . n 
A 1 195  THR 195  195  ?    ?   ?   C . n 
A 1 196  CYS 196  196  ?    ?   ?   C . n 
A 1 197  GLU 197  197  ?    ?   ?   C . n 
A 1 198  SER 198  198  ?    ?   ?   C . n 
A 1 199  PRO 199  199  ?    ?   ?   C . n 
A 1 200  VAL 200  200  ?    ?   ?   C . n 
A 1 201  SER 201  201  201  SER SER C . n 
A 1 202  PRO 202  202  202  PRO PRO C . n 
A 1 203  ILE 203  203  203  ILE ILE C . n 
A 1 204  LYS 204  204  204  LYS LYS C . n 
A 1 205  MET 205  205  205  MET MET C . n 
A 1 206  GLU 206  206  206  GLU GLU C . n 
A 1 207  LEU 207  207  207  LEU LEU C . n 
A 1 208  LEU 208  208  208  LEU LEU C . n 
A 1 209  PHE 209  209  209  PHE PHE C . n 
A 1 210  ASP 210  210  210  ASP ASP C . n 
A 1 211  PRO 211  211  211  PRO PRO C . n 
A 1 212  ASP 212  212  212  ASP ASP C . n 
A 1 213  ASP 213  213  213  ASP ASP C . n 
A 1 214  GLU 214  214  214  GLU GLU C . n 
A 1 215  HIS 215  215  215  HIS HIS C . n 
A 1 216  SER 216  216  216  SER SER C . n 
A 1 217  GLU 217  217  217  GLU GLU C . n 
A 1 218  PRO 218  218  218  PRO PRO C . n 
A 1 219  VAL 219  219  219  VAL VAL C . n 
A 1 220  HIS 220  220  220  HIS HIS C . n 
A 1 221  THR 221  221  221  THR THR C . n 
A 1 222  VAL 222  222  222  VAL VAL C . n 
A 1 223  VAL 223  223  223  VAL VAL C . n 
A 1 224  PHE 224  224  224  PHE PHE C . n 
A 1 225  GLN 225  225  225  GLN GLN C . n 
A 1 226  GLY 226  226  226  GLY GLY C . n 
A 1 227  ALA 227  227  227  ALA ALA C . n 
A 1 228  ALA 228  228  228  ALA ALA C . n 
A 1 229  GLY 229  229  229  GLY GLY C . n 
A 1 230  ILE 230  230  230  ILE ILE C . n 
A 1 231  GLY 231  231  231  GLY GLY C . n 
A 1 232  LYS 232  232  232  LYS LYS C . n 
A 1 233  THR 233  233  233  THR THR C . n 
A 1 234  ILE 234  234  234  ILE ILE C . n 
A 1 235  LEU 235  235  235  LEU LEU C . n 
A 1 236  ALA 236  236  236  ALA ALA C . n 
A 1 237  ARG 237  237  237  ARG ARG C . n 
A 1 238  LYS 238  238  238  LYS LYS C . n 
A 1 239  MET 239  239  239  MET MET C . n 
A 1 240  MET 240  240  240  MET MET C . n 
A 1 241  LEU 241  241  241  LEU LEU C . n 
A 1 242  ASP 242  242  242  ASP ASP C . n 
A 1 243  TRP 243  243  243  TRP TRP C . n 
A 1 244  ALA 244  244  244  ALA ALA C . n 
A 1 245  SER 245  245  245  SER SER C . n 
A 1 246  GLY 246  246  246  GLY GLY C . n 
A 1 247  THR 247  247  247  THR THR C . n 
A 1 248  LEU 248  248  248  LEU LEU C . n 
A 1 249  TYR 249  249  249  TYR TYR C . n 
A 1 250  GLN 250  250  250  GLN GLN C . n 
A 1 251  ASP 251  251  251  ASP ASP C . n 
A 1 252  ARG 252  252  252  ARG ARG C . n 
A 1 253  PHE 253  253  253  PHE PHE C . n 
A 1 254  ASP 254  254  254  ASP ASP C . n 
A 1 255  TYR 255  255  255  TYR TYR C . n 
A 1 256  LEU 256  256  256  LEU LEU C . n 
A 1 257  PHE 257  257  257  PHE PHE C . n 
A 1 258  TYR 258  258  258  TYR TYR C . n 
A 1 259  ILE 259  259  259  ILE ILE C . n 
A 1 260  HIS 260  260  260  HIS HIS C . n 
A 1 261  CYS 261  261  261  CYS CYS C . n 
A 1 262  ARG 262  262  262  ARG ARG C . n 
A 1 263  GLU 263  263  263  GLU GLU C . n 
A 1 264  VAL 264  264  264  VAL VAL C . n 
A 1 265  SER 265  265  265  SER SER C . n 
A 1 266  LEU 266  266  266  LEU LEU C . n 
A 1 267  VAL 267  267  267  VAL VAL C . n 
A 1 268  THR 268  268  268  THR THR C . n 
A 1 269  GLN 269  269  269  GLN GLN C . n 
A 1 270  ARG 270  270  270  ARG ARG C . n 
A 1 271  SER 271  271  271  SER SER C . n 
A 1 272  LEU 272  272  272  LEU LEU C . n 
A 1 273  GLY 273  273  273  GLY GLY C . n 
A 1 274  ASP 274  274  274  ASP ASP C . n 
A 1 275  LEU 275  275  275  LEU LEU C . n 
A 1 276  ILE 276  276  276  ILE ILE C . n 
A 1 277  MET 277  277  277  MET MET C . n 
A 1 278  SER 278  278  278  SER SER C . n 
A 1 279  CYS 279  279  279  CYS CYS C . n 
A 1 280  CYS 280  280  280  CYS CYS C . n 
A 1 281  PRO 281  281  281  PRO PRO C . n 
A 1 282  ASP 282  282  282  ASP ASP C . n 
A 1 283  PRO 283  283  283  PRO PRO C . n 
A 1 284  ASN 284  284  284  ASN ASN C . n 
A 1 285  PRO 285  285  285  PRO PRO C . n 
A 1 286  PRO 286  286  286  PRO PRO C . n 
A 1 287  ILE 287  287  287  ILE ILE C . n 
A 1 288  HIS 288  288  288  HIS HIS C . n 
A 1 289  LYS 289  289  289  LYS LYS C . n 
A 1 290  ILE 290  290  290  ILE ILE C . n 
A 1 291  VAL 291  291  291  VAL VAL C . n 
A 1 292  ARG 292  292  292  ARG ARG C . n 
A 1 293  LYS 293  293  293  LYS LYS C . n 
A 1 294  PRO 294  294  294  PRO PRO C . n 
A 1 295  SER 295  295  295  SER SER C . n 
A 1 296  ARG 296  296  296  ARG ARG C . n 
A 1 297  ILE 297  297  297  ILE ILE C . n 
A 1 298  LEU 298  298  298  LEU LEU C . n 
A 1 299  PHE 299  299  299  PHE PHE C . n 
A 1 300  LEU 300  300  300  LEU LEU C . n 
A 1 301  MET 301  301  301  MET MET C . n 
A 1 302  ASP 302  302  302  ASP ASP C . n 
A 1 303  GLY 303  303  303  GLY GLY C . n 
A 1 304  PHE 304  304  304  PHE PHE C . n 
A 1 305  ASP 305  305  305  ASP ASP C . n 
A 1 306  GLU 306  306  306  GLU GLU C . n 
A 1 307  LEU 307  307  307  LEU LEU C . n 
A 1 308  GLN 308  308  308  GLN GLN C . n 
A 1 309  GLY 309  309  309  GLY GLY C . n 
A 1 310  ALA 310  310  310  ALA ALA C . n 
A 1 311  PHE 311  311  311  PHE PHE C . n 
A 1 312  ASP 312  312  312  ASP ASP C . n 
A 1 313  GLU 313  313  313  GLU GLU C . n 
A 1 314  HIS 314  314  314  HIS HIS C . n 
A 1 315  ILE 315  315  315  ILE ILE C . n 
A 1 316  GLY 316  316  316  GLY GLY C . n 
A 1 317  PRO 317  317  317  PRO PRO C . n 
A 1 318  LEU 318  318  318  LEU LEU C . n 
A 1 319  CYS 319  319  319  CYS CYS C . n 
A 1 320  THR 320  320  320  THR THR C . n 
A 1 321  ASP 321  321  321  ASP ASP C . n 
A 1 322  TRP 322  322  322  TRP TRP C . n 
A 1 323  GLN 323  323  323  GLN GLN C . n 
A 1 324  LYS 324  324  324  LYS LYS C . n 
A 1 325  ALA 325  325  325  ALA ALA C . n 
A 1 326  GLU 326  326  326  GLU GLU C . n 
A 1 327  ARG 327  327  327  ARG ARG C . n 
A 1 328  GLY 328  328  328  GLY GLY C . n 
A 1 329  ASP 329  329  329  ASP ASP C . n 
A 1 330  ILE 330  330  330  ILE ILE C . n 
A 1 331  LEU 331  331  331  LEU LEU C . n 
A 1 332  LEU 332  332  332  LEU LEU C . n 
A 1 333  SER 333  333  333  SER SER C . n 
A 1 334  SER 334  334  334  SER SER C . n 
A 1 335  LEU 335  335  335  LEU LEU C . n 
A 1 336  ILE 336  336  336  ILE ILE C . n 
A 1 337  ARG 337  337  337  ARG ARG C . n 
A 1 338  LYS 338  338  338  LYS LYS C . n 
A 1 339  LYS 339  339  339  LYS LYS C . n 
A 1 340  LEU 340  340  340  LEU LEU C . n 
A 1 341  LEU 341  341  341  LEU LEU C . n 
A 1 342  PRO 342  342  342  PRO PRO C . n 
A 1 343  GLU 343  343  343  GLU GLU C . n 
A 1 344  ALA 344  344  344  ALA ALA C . n 
A 1 345  SER 345  345  345  SER SER C . n 
A 1 346  LEU 346  346  346  LEU LEU C . n 
A 1 347  LEU 347  347  347  LEU LEU C . n 
A 1 348  ILE 348  348  348  ILE ILE C . n 
A 1 349  THR 349  349  349  THR THR C . n 
A 1 350  THR 350  350  350  THR THR C . n 
A 1 351  ARG 351  351  351  ARG ARG C . n 
A 1 352  PRO 352  352  352  PRO PRO C . n 
A 1 353  VAL 353  353  353  VAL VAL C . n 
A 1 354  ALA 354  354  354  ALA ALA C . n 
A 1 355  LEU 355  355  355  LEU LEU C . n 
A 1 356  GLU 356  356  356  GLU GLU C . n 
A 1 357  LYS 357  357  357  LYS LYS C . n 
A 1 358  LEU 358  358  358  LEU LEU C . n 
A 1 359  GLN 359  359  359  GLN GLN C . n 
A 1 360  HIS 360  360  360  HIS HIS C . n 
A 1 361  LEU 361  361  361  LEU LEU C . n 
A 1 362  LEU 362  362  362  LEU LEU C . n 
A 1 363  ASP 363  363  363  ASP ASP C . n 
A 1 364  HIS 364  364  364  HIS HIS C . n 
A 1 365  PRO 365  365  365  PRO PRO C . n 
A 1 366  ARG 366  366  366  ARG ARG C . n 
A 1 367  HIS 367  367  367  HIS HIS C . n 
A 1 368  VAL 368  368  368  VAL VAL C . n 
A 1 369  GLU 369  369  369  GLU GLU C . n 
A 1 370  ILE 370  370  370  ILE ILE C . n 
A 1 371  LEU 371  371  371  LEU LEU C . n 
A 1 372  GLY 372  372  372  GLY GLY C . n 
A 1 373  PHE 373  373  373  PHE PHE C . n 
A 1 374  SER 374  374  374  SER SER C . n 
A 1 375  GLU 375  375  375  GLU GLU C . n 
A 1 376  ALA 376  376  376  ALA ALA C . n 
A 1 377  LYS 377  377  377  LYS LYS C . n 
A 1 378  ARG 378  378  378  ARG ARG C . n 
A 1 379  LYS 379  379  379  LYS LYS C . n 
A 1 380  GLU 380  380  380  GLU GLU C . n 
A 1 381  TYR 381  381  381  TYR TYR C . n 
A 1 382  PHE 382  382  382  PHE PHE C . n 
A 1 383  PHE 383  383  383  PHE PHE C . n 
A 1 384  LYS 384  384  384  LYS LYS C . n 
A 1 385  TYR 385  385  385  TYR TYR C . n 
A 1 386  PHE 386  386  386  PHE PHE C . n 
A 1 387  SER 387  387  387  SER SER C . n 
A 1 388  ASP 388  388  388  ASP ASP C . n 
A 1 389  GLU 389  389  389  GLU GLU C . n 
A 1 390  ALA 390  390  390  ALA ALA C . n 
A 1 391  GLN 391  391  391  GLN GLN C . n 
A 1 392  ALA 392  392  392  ALA ALA C . n 
A 1 393  ARG 393  393  393  ARG ARG C . n 
A 1 394  ALA 394  394  394  ALA ALA C . n 
A 1 395  ALA 395  395  395  ALA ALA C . n 
A 1 396  PHE 396  396  396  PHE PHE C . n 
A 1 397  SER 397  397  397  SER SER C . n 
A 1 398  LEU 398  398  398  LEU LEU C . n 
A 1 399  ILE 399  399  399  ILE ILE C . n 
A 1 400  GLN 400  400  400  GLN GLN C . n 
A 1 401  GLU 401  401  401  GLU GLU C . n 
A 1 402  ASN 402  402  402  ASN ASN C . n 
A 1 403  GLU 403  403  403  GLU GLU C . n 
A 1 404  VAL 404  404  404  VAL VAL C . n 
A 1 405  LEU 405  405  405  LEU LEU C . n 
A 1 406  PHE 406  406  406  PHE PHE C . n 
A 1 407  THR 407  407  407  THR THR C . n 
A 1 408  MET 408  408  408  MET MET C . n 
A 1 409  CYS 409  409  409  CYS CYS C . n 
A 1 410  PHE 410  410  410  PHE PHE C . n 
A 1 411  ILE 411  411  411  ILE ILE C . n 
A 1 412  PRO 412  412  412  PRO PRO C . n 
A 1 413  LEU 413  413  413  LEU LEU C . n 
A 1 414  VAL 414  414  414  VAL VAL C . n 
A 1 415  CYS 415  415  415  CYS CYS C . n 
A 1 416  TRP 416  416  416  TRP TRP C . n 
A 1 417  ILE 417  417  417  ILE ILE C . n 
A 1 418  VAL 418  418  418  VAL VAL C . n 
A 1 419  CYS 419  419  419  CYS CYS C . n 
A 1 420  THR 420  420  420  THR THR C . n 
A 1 421  GLY 421  421  421  GLY GLY C . n 
A 1 422  LEU 422  422  422  LEU LEU C . n 
A 1 423  LYS 423  423  423  LYS LYS C . n 
A 1 424  GLN 424  424  424  GLN GLN C . n 
A 1 425  GLN 425  425  425  GLN GLN C . n 
A 1 426  MET 426  426  426  MET MET C . n 
A 1 427  GLU 427  427  427  GLU GLU C . n 
A 1 428  SER 428  428  428  SER SER C . n 
A 1 429  GLY 429  429  429  GLY GLY C . n 
A 1 430  LYS 430  430  430  LYS LYS C . n 
A 1 431  SER 431  431  431  SER SER C . n 
A 1 432  LEU 432  432  432  LEU LEU C . n 
A 1 433  ALA 433  433  433  ALA ALA C . n 
A 1 434  GLN 434  434  434  GLN GLN C . n 
A 1 435  THR 435  435  435  THR THR C . n 
A 1 436  SER 436  436  436  SER SER C . n 
A 1 437  LYS 437  437  437  LYS LYS C . n 
A 1 438  THR 438  438  438  THR THR C . n 
A 1 439  THR 439  439  439  THR THR C . n 
A 1 440  THR 440  440  440  THR THR C . n 
A 1 441  ALA 441  441  441  ALA ALA C . n 
A 1 442  VAL 442  442  442  VAL VAL C . n 
A 1 443  TYR 443  443  443  TYR TYR C . n 
A 1 444  VAL 444  444  444  VAL VAL C . n 
A 1 445  PHE 445  445  445  PHE PHE C . n 
A 1 446  PHE 446  446  446  PHE PHE C . n 
A 1 447  LEU 447  447  447  LEU LEU C . n 
A 1 448  SER 448  448  448  SER SER C . n 
A 1 449  SER 449  449  449  SER SER C . n 
A 1 450  LEU 450  450  450  LEU LEU C . n 
A 1 451  LEU 451  451  451  LEU LEU C . n 
A 1 452  GLN 452  452  452  GLN GLN C . n 
A 1 453  PRO 453  453  453  PRO PRO C . n 
A 1 454  ARG 454  454  ?    ?   ?   C . n 
A 1 455  GLY 455  455  ?    ?   ?   C . n 
A 1 456  GLY 456  456  ?    ?   ?   C . n 
A 1 457  SER 457  457  ?    ?   ?   C . n 
A 1 458  GLN 458  458  ?    ?   ?   C . n 
A 1 459  GLU 459  459  ?    ?   ?   C . n 
A 1 460  HIS 460  460  ?    ?   ?   C . n 
A 1 461  GLY 461  461  ?    ?   ?   C . n 
A 1 462  LEU 462  462  462  LEU LEU C . n 
A 1 463  CYS 463  463  463  CYS CYS C . n 
A 1 464  ALA 464  464  464  ALA ALA C . n 
A 1 465  HIS 465  465  465  HIS HIS C . n 
A 1 466  LEU 466  466  466  LEU LEU C . n 
A 1 467  TRP 467  467  467  TRP TRP C . n 
A 1 468  GLY 468  468  468  GLY GLY C . n 
A 1 469  LEU 469  469  469  LEU LEU C . n 
A 1 470  CYS 470  470  470  CYS CYS C . n 
A 1 471  SER 471  471  471  SER SER C . n 
A 1 472  LEU 472  472  472  LEU LEU C . n 
A 1 473  ALA 473  473  473  ALA ALA C . n 
A 1 474  ALA 474  474  474  ALA ALA C . n 
A 1 475  ASP 475  475  475  ASP ASP C . n 
A 1 476  GLY 476  476  476  GLY GLY C . n 
A 1 477  ILE 477  477  477  ILE ILE C . n 
A 1 478  TRP 478  478  478  TRP TRP C . n 
A 1 479  ASN 479  479  479  ASN ASN C . n 
A 1 480  GLN 480  480  480  GLN GLN C . n 
A 1 481  LYS 481  481  481  LYS LYS C . n 
A 1 482  ILE 482  482  482  ILE ILE C . n 
A 1 483  LEU 483  483  483  LEU LEU C . n 
A 1 484  PHE 484  484  484  PHE PHE C . n 
A 1 485  GLU 485  485  485  GLU GLU C . n 
A 1 486  GLU 486  486  486  GLU GLU C . n 
A 1 487  SER 487  487  487  SER SER C . n 
A 1 488  ASP 488  488  488  ASP ASP C . n 
A 1 489  LEU 489  489  489  LEU LEU C . n 
A 1 490  ARG 490  490  490  ARG ARG C . n 
A 1 491  ASN 491  491  491  ASN ASN C . n 
A 1 492  HIS 492  492  492  HIS HIS C . n 
A 1 493  GLY 493  493  493  GLY GLY C . n 
A 1 494  LEU 494  494  494  LEU LEU C . n 
A 1 495  GLN 495  495  495  GLN GLN C . n 
A 1 496  LYS 496  496  496  LYS LYS C . n 
A 1 497  ALA 497  497  497  ALA ALA C . n 
A 1 498  ASP 498  498  498  ASP ASP C . n 
A 1 499  VAL 499  499  499  VAL VAL C . n 
A 1 500  SER 500  500  500  SER SER C . n 
A 1 501  ALA 501  501  501  ALA ALA C . n 
A 1 502  PHE 502  502  502  PHE PHE C . n 
A 1 503  LEU 503  503  503  LEU LEU C . n 
A 1 504  ARG 504  504  504  ARG ARG C . n 
A 1 505  MET 505  505  505  MET MET C . n 
A 1 506  ASN 506  506  506  ASN ASN C . n 
A 1 507  LEU 507  507  507  LEU LEU C . n 
A 1 508  PHE 508  508  508  PHE PHE C . n 
A 1 509  GLN 509  509  509  GLN GLN C . n 
A 1 510  LYS 510  510  510  LYS LYS C . n 
A 1 511  GLU 511  511  511  GLU GLU C . n 
A 1 512  VAL 512  512  512  VAL VAL C . n 
A 1 513  ASP 513  513  513  ASP ASP C . n 
A 1 514  CYS 514  514  514  CYS CYS C . n 
A 1 515  GLU 515  515  515  GLU GLU C . n 
A 1 516  LYS 516  516  516  LYS LYS C . n 
A 1 517  PHE 517  517  517  PHE PHE C . n 
A 1 518  TYR 518  518  518  TYR TYR C . n 
A 1 519  SER 519  519  519  SER SER C . n 
A 1 520  PHE 520  520  520  PHE PHE C . n 
A 1 521  ILE 521  521  521  ILE ILE C . n 
A 1 522  HIS 522  522  522  HIS HIS C . n 
A 1 523  MET 523  523  523  MET MET C . n 
A 1 524  THR 524  524  524  THR THR C . n 
A 1 525  PHE 525  525  525  PHE PHE C . n 
A 1 526  GLN 526  526  526  GLN GLN C . n 
A 1 527  GLU 527  527  527  GLU GLU C . n 
A 1 528  PHE 528  528  528  PHE PHE C . n 
A 1 529  PHE 529  529  529  PHE PHE C . n 
A 1 530  ALA 530  530  530  ALA ALA C . n 
A 1 531  ALA 531  531  531  ALA ALA C . n 
A 1 532  MET 532  532  532  MET MET C . n 
A 1 533  TYR 533  533  533  TYR TYR C . n 
A 1 534  TYR 534  534  534  TYR TYR C . n 
A 1 535  LEU 535  535  535  LEU LEU C . n 
A 1 536  LEU 536  536  536  LEU LEU C . n 
A 1 537  GLU 537  537  537  GLU GLU C . n 
A 1 538  GLU 538  538  ?    ?   ?   C . n 
A 1 539  GLU 539  539  ?    ?   ?   C . n 
A 1 540  LYS 540  540  ?    ?   ?   C . n 
A 1 541  GLU 541  541  ?    ?   ?   C . n 
A 1 542  GLY 542  542  ?    ?   ?   C . n 
A 1 543  ARG 543  543  ?    ?   ?   C . n 
A 1 544  THR 544  544  ?    ?   ?   C . n 
A 1 545  ASN 545  545  ?    ?   ?   C . n 
A 1 546  VAL 546  546  ?    ?   ?   C . n 
A 1 547  PRO 547  547  ?    ?   ?   C . n 
A 1 548  GLY 548  548  ?    ?   ?   C . n 
A 1 549  SER 549  549  ?    ?   ?   C . n 
A 1 550  ARG 550  550  ?    ?   ?   C . n 
A 1 551  LEU 551  551  ?    ?   ?   C . n 
A 1 552  LYS 552  552  ?    ?   ?   C . n 
A 1 553  LEU 553  553  553  LEU LEU C . n 
A 1 554  PRO 554  554  554  PRO PRO C . n 
A 1 555  SER 555  555  555  SER SER C . n 
A 1 556  ARG 556  556  556  ARG ARG C . n 
A 1 557  ASP 557  557  557  ASP ASP C . n 
A 1 558  VAL 558  558  558  VAL VAL C . n 
A 1 559  THR 559  559  559  THR THR C . n 
A 1 560  VAL 560  560  560  VAL VAL C . n 
A 1 561  LEU 561  561  561  LEU LEU C . n 
A 1 562  LEU 562  562  562  LEU LEU C . n 
A 1 563  GLU 563  563  563  GLU GLU C . n 
A 1 564  ASN 564  564  564  ASN ASN C . n 
A 1 565  TYR 565  565  565  TYR TYR C . n 
A 1 566  GLY 566  566  566  GLY GLY C . n 
A 1 567  LYS 567  567  567  LYS LYS C . n 
A 1 568  PHE 568  568  568  PHE PHE C . n 
A 1 569  GLU 569  569  569  GLU GLU C . n 
A 1 570  LYS 570  570  570  LYS LYS C . n 
A 1 571  GLY 571  571  571  GLY GLY C . n 
A 1 572  TYR 572  572  572  TYR TYR C . n 
A 1 573  LEU 573  573  573  LEU LEU C . n 
A 1 574  ILE 574  574  574  ILE ILE C . n 
A 1 575  PHE 575  575  575  PHE PHE C . n 
A 1 576  VAL 576  576  576  VAL VAL C . n 
A 1 577  VAL 577  577  577  VAL VAL C . n 
A 1 578  ARG 578  578  578  ARG ARG C . n 
A 1 579  PHE 579  579  579  PHE PHE C . n 
A 1 580  LEU 580  580  580  LEU LEU C . n 
A 1 581  PHE 581  581  581  PHE PHE C . n 
A 1 582  GLY 582  582  582  GLY GLY C . n 
A 1 583  LEU 583  583  583  LEU LEU C . n 
A 1 584  VAL 584  584  584  VAL VAL C . n 
A 1 585  ASN 585  585  585  ASN ASN C . n 
A 1 586  GLN 586  586  586  GLN GLN C . n 
A 1 587  GLU 587  587  587  GLU GLU C . n 
A 1 588  ARG 588  588  588  ARG ARG C . n 
A 1 589  THR 589  589  589  THR THR C . n 
A 1 590  SER 590  590  590  SER SER C . n 
A 1 591  TYR 591  591  591  TYR TYR C . n 
A 1 592  LEU 592  592  592  LEU LEU C . n 
A 1 593  GLU 593  593  593  GLU GLU C . n 
A 1 594  LYS 594  594  594  LYS LYS C . n 
A 1 595  LYS 595  595  595  LYS LYS C . n 
A 1 596  LEU 596  596  596  LEU LEU C . n 
A 1 597  SER 597  597  597  SER SER C . n 
A 1 598  CYS 598  598  598  CYS CYS C . n 
A 1 599  LYS 599  599  599  LYS LYS C . n 
A 1 600  ILE 600  600  600  ILE ILE C . n 
A 1 601  SER 601  601  601  SER SER C . n 
A 1 602  GLN 602  602  602  GLN GLN C . n 
A 1 603  GLN 603  603  603  GLN GLN C . n 
A 1 604  ILE 604  604  604  ILE ILE C . n 
A 1 605  ARG 605  605  605  ARG ARG C . n 
A 1 606  LEU 606  606  606  LEU LEU C . n 
A 1 607  GLU 607  607  607  GLU GLU C . n 
A 1 608  LEU 608  608  608  LEU LEU C . n 
A 1 609  LEU 609  609  609  LEU LEU C . n 
A 1 610  LYS 610  610  610  LYS LYS C . n 
A 1 611  TRP 611  611  611  TRP TRP C . n 
A 1 612  ILE 612  612  612  ILE ILE C . n 
A 1 613  GLU 613  613  613  GLU GLU C . n 
A 1 614  VAL 614  614  614  VAL VAL C . n 
A 1 615  LYS 615  615  615  LYS LYS C . n 
A 1 616  ALA 616  616  616  ALA ALA C . n 
A 1 617  LYS 617  617  617  LYS LYS C . n 
A 1 618  ALA 618  618  618  ALA ALA C . n 
A 1 619  LYS 619  619  619  LYS LYS C . n 
A 1 620  LYS 620  620  620  LYS LYS C . n 
A 1 621  LEU 621  621  621  LEU LEU C . n 
A 1 622  GLN 622  622  622  GLN GLN C . n 
A 1 623  ILE 623  623  623  ILE ILE C . n 
A 1 624  GLN 624  624  624  GLN GLN C . n 
A 1 625  PRO 625  625  625  PRO PRO C . n 
A 1 626  SER 626  626  626  SER SER C . n 
A 1 627  GLN 627  627  627  GLN GLN C . n 
A 1 628  LEU 628  628  628  LEU LEU C . n 
A 1 629  GLU 629  629  629  GLU GLU C . n 
A 1 630  LEU 630  630  630  LEU LEU C . n 
A 1 631  PHE 631  631  631  PHE PHE C . n 
A 1 632  TYR 632  632  632  TYR TYR C . n 
A 1 633  CYS 633  633  633  CYS CYS C . n 
A 1 634  LEU 634  634  634  LEU LEU C . n 
A 1 635  TYR 635  635  635  TYR TYR C . n 
A 1 636  GLU 636  636  636  GLU GLU C . n 
A 1 637  MET 637  637  637  MET MET C . n 
A 1 638  GLN 638  638  638  GLN GLN C . n 
A 1 639  GLU 639  639  639  GLU GLU C . n 
A 1 640  GLU 640  640  640  GLU GLU C . n 
A 1 641  ASP 641  641  641  ASP ASP C . n 
A 1 642  PHE 642  642  642  PHE PHE C . n 
A 1 643  VAL 643  643  643  VAL VAL C . n 
A 1 644  GLN 644  644  644  GLN GLN C . n 
A 1 645  ARG 645  645  645  ARG ARG C . n 
A 1 646  ALA 646  646  646  ALA ALA C . n 
A 1 647  MET 647  647  647  MET MET C . n 
A 1 648  ASP 648  648  648  ASP ASP C . n 
A 1 649  TYR 649  649  649  TYR TYR C . n 
A 1 650  PHE 650  650  650  PHE PHE C . n 
A 1 651  PRO 651  651  651  PRO PRO C . n 
A 1 652  LYS 652  652  652  LYS LYS C . n 
A 1 653  ILE 653  653  653  ILE ILE C . n 
A 1 654  GLU 654  654  654  GLU GLU C . n 
A 1 655  ILE 655  655  655  ILE ILE C . n 
A 1 656  ASN 656  656  656  ASN ASN C . n 
A 1 657  LEU 657  657  657  LEU LEU C . n 
A 1 658  SER 658  658  658  SER SER C . n 
A 1 659  THR 659  659  659  THR THR C . n 
A 1 660  ARG 660  660  660  ARG ARG C . n 
A 1 661  MET 661  661  661  MET MET C . n 
A 1 662  ASP 662  662  662  ASP ASP C . n 
A 1 663  HIS 663  663  663  HIS HIS C . n 
A 1 664  MET 664  664  664  MET MET C . n 
A 1 665  VAL 665  665  665  VAL VAL C . n 
A 1 666  SER 666  666  666  SER SER C . n 
A 1 667  SER 667  667  667  SER SER C . n 
A 1 668  PHE 668  668  668  PHE PHE C . n 
A 1 669  CYS 669  669  669  CYS CYS C . n 
A 1 670  ILE 670  670  670  ILE ILE C . n 
A 1 671  GLU 671  671  671  GLU GLU C . n 
A 1 672  ASN 672  672  672  ASN ASN C . n 
A 1 673  CYS 673  673  673  CYS CYS C . n 
A 1 674  HIS 674  674  674  HIS HIS C . n 
A 1 675  ARG 675  675  675  ARG ARG C . n 
A 1 676  VAL 676  676  676  VAL VAL C . n 
A 1 677  GLU 677  677  677  GLU GLU C . n 
A 1 678  SER 678  678  678  SER SER C . n 
A 1 679  LEU 679  679  679  LEU LEU C . n 
A 1 680  SER 680  680  680  SER SER C . n 
A 1 681  LEU 681  681  681  LEU LEU C . n 
A 1 682  GLY 682  682  682  GLY GLY C . n 
A 1 683  PHE 683  683  683  PHE PHE C . n 
A 1 684  LEU 684  684  684  LEU LEU C . n 
A 1 685  HIS 685  685  685  HIS HIS C . n 
A 1 686  ASN 686  686  686  ASN ASN C . n 
A 1 687  MET 687  687  ?    ?   ?   C . n 
A 1 688  PRO 688  688  ?    ?   ?   C . n 
A 1 689  LYS 689  689  ?    ?   ?   C . n 
A 1 690  GLU 690  690  ?    ?   ?   C . n 
A 1 691  GLU 691  691  ?    ?   ?   C . n 
A 1 692  GLU 692  692  ?    ?   ?   C . n 
A 1 693  GLU 693  693  ?    ?   ?   C . n 
A 1 694  GLU 694  694  ?    ?   ?   C . n 
A 1 695  GLU 695  695  ?    ?   ?   C . n 
A 1 696  LYS 696  696  ?    ?   ?   C . n 
A 1 697  GLU 697  697  ?    ?   ?   C . n 
A 1 698  GLY 698  698  ?    ?   ?   C . n 
A 1 699  ARG 699  699  ?    ?   ?   C . n 
A 1 700  HIS 700  700  ?    ?   ?   C . n 
A 1 701  LEU 701  701  ?    ?   ?   C . n 
A 1 702  ASP 702  702  ?    ?   ?   C . n 
A 1 703  MET 703  703  ?    ?   ?   C . n 
A 1 704  VAL 704  704  ?    ?   ?   C . n 
A 1 705  GLN 705  705  ?    ?   ?   C . n 
A 1 706  CYS 706  706  ?    ?   ?   C . n 
A 1 707  VAL 707  707  ?    ?   ?   C . n 
A 1 708  LEU 708  708  ?    ?   ?   C . n 
A 1 709  PRO 709  709  ?    ?   ?   C . n 
A 1 710  SER 710  710  ?    ?   ?   C . n 
A 1 711  SER 711  711  ?    ?   ?   C . n 
A 1 712  SER 712  712  ?    ?   ?   C . n 
A 1 713  HIS 713  713  ?    ?   ?   C . n 
A 1 714  ALA 714  714  ?    ?   ?   C . n 
A 1 715  ALA 715  715  ?    ?   ?   C . n 
A 1 716  CYS 716  716  ?    ?   ?   C . n 
A 1 717  SER 717  717  ?    ?   ?   C . n 
A 1 718  HIS 718  718  ?    ?   ?   C . n 
A 1 719  GLY 719  719  ?    ?   ?   C . n 
A 1 720  LEU 720  720  ?    ?   ?   C . n 
A 1 721  VAL 721  721  ?    ?   ?   C . n 
A 1 722  ASN 722  722  ?    ?   ?   C . n 
A 1 723  SER 723  723  ?    ?   ?   C . n 
A 1 724  HIS 724  724  ?    ?   ?   C . n 
A 1 725  LEU 725  725  725  LEU LEU C . n 
A 1 726  THR 726  726  726  THR THR C . n 
A 1 727  SER 727  727  727  SER SER C . n 
A 1 728  SER 728  728  728  SER SER C . n 
A 1 729  PHE 729  729  729  PHE PHE C . n 
A 1 730  CYS 730  730  730  CYS CYS C . n 
A 1 731  ARG 731  731  731  ARG ARG C . n 
A 1 732  GLY 732  732  732  GLY GLY C . n 
A 1 733  LEU 733  733  733  LEU LEU C . n 
A 1 734  PHE 734  734  734  PHE PHE C . n 
A 1 735  SER 735  735  735  SER SER C . n 
A 1 736  VAL 736  736  736  VAL VAL C . n 
A 1 737  LEU 737  737  737  LEU LEU C . n 
A 1 738  SER 738  738  738  SER SER C . n 
A 1 739  THR 739  739  739  THR THR C . n 
A 1 740  SER 740  740  740  SER SER C . n 
A 1 741  GLN 741  741  741  GLN GLN C . n 
A 1 742  SER 742  742  742  SER SER C . n 
A 1 743  LEU 743  743  743  LEU LEU C . n 
A 1 744  THR 744  744  744  THR THR C . n 
A 1 745  GLU 745  745  745  GLU GLU C . n 
A 1 746  LEU 746  746  746  LEU LEU C . n 
A 1 747  ASP 747  747  747  ASP ASP C . n 
A 1 748  LEU 748  748  748  LEU LEU C . n 
A 1 749  SER 749  749  749  SER SER C . n 
A 1 750  ASP 750  750  750  ASP ASP C . n 
A 1 751  ASN 751  751  751  ASN ASN C . n 
A 1 752  SER 752  752  752  SER SER C . n 
A 1 753  LEU 753  753  753  LEU LEU C . n 
A 1 754  GLY 754  754  754  GLY GLY C . n 
A 1 755  ASP 755  755  755  ASP ASP C . n 
A 1 756  PRO 756  756  756  PRO PRO C . n 
A 1 757  GLY 757  757  757  GLY GLY C . n 
A 1 758  MET 758  758  758  MET MET C . n 
A 1 759  ARG 759  759  759  ARG ARG C . n 
A 1 760  VAL 760  760  760  VAL VAL C . n 
A 1 761  LEU 761  761  761  LEU LEU C . n 
A 1 762  CYS 762  762  762  CYS CYS C . n 
A 1 763  GLU 763  763  763  GLU GLU C . n 
A 1 764  THR 764  764  764  THR THR C . n 
A 1 765  LEU 765  765  765  LEU LEU C . n 
A 1 766  GLN 766  766  766  GLN GLN C . n 
A 1 767  HIS 767  767  767  HIS HIS C . n 
A 1 768  PRO 768  768  768  PRO PRO C . n 
A 1 769  GLY 769  769  769  GLY GLY C . n 
A 1 770  CYS 770  770  770  CYS CYS C . n 
A 1 771  ASN 771  771  771  ASN ASN C . n 
A 1 772  ILE 772  772  772  ILE ILE C . n 
A 1 773  ARG 773  773  773  ARG ARG C . n 
A 1 774  ARG 774  774  774  ARG ARG C . n 
A 1 775  LEU 775  775  775  LEU LEU C . n 
A 1 776  TRP 776  776  776  TRP TRP C . n 
A 1 777  LEU 777  777  777  LEU LEU C . n 
A 1 778  GLY 778  778  778  GLY GLY C . n 
A 1 779  ARG 779  779  779  ARG ARG C . n 
A 1 780  CYS 780  780  780  CYS CYS C . n 
A 1 781  GLY 781  781  781  GLY GLY C . n 
A 1 782  LEU 782  782  782  LEU LEU C . n 
A 1 783  SER 783  783  783  SER SER C . n 
A 1 784  HIS 784  784  784  HIS HIS C . n 
A 1 785  GLU 785  785  785  GLU GLU C . n 
A 1 786  CYS 786  786  786  CYS CYS C . n 
A 1 787  CYS 787  787  787  CYS CYS C . n 
A 1 788  PHE 788  788  788  PHE PHE C . n 
A 1 789  ASP 789  789  789  ASP ASP C . n 
A 1 790  ILE 790  790  790  ILE ILE C . n 
A 1 791  SER 791  791  791  SER SER C . n 
A 1 792  LEU 792  792  792  LEU LEU C . n 
A 1 793  VAL 793  793  793  VAL VAL C . n 
A 1 794  LEU 794  794  794  LEU LEU C . n 
A 1 795  SER 795  795  795  SER SER C . n 
A 1 796  SER 796  796  796  SER SER C . n 
A 1 797  ASN 797  797  797  ASN ASN C . n 
A 1 798  GLN 798  798  798  GLN GLN C . n 
A 1 799  LYS 799  799  799  LYS LYS C . n 
A 1 800  LEU 800  800  800  LEU LEU C . n 
A 1 801  VAL 801  801  801  VAL VAL C . n 
A 1 802  GLU 802  802  802  GLU GLU C . n 
A 1 803  LEU 803  803  803  LEU LEU C . n 
A 1 804  ASP 804  804  804  ASP ASP C . n 
A 1 805  LEU 805  805  805  LEU LEU C . n 
A 1 806  SER 806  806  806  SER SER C . n 
A 1 807  ASP 807  807  807  ASP ASP C . n 
A 1 808  ASN 808  808  808  ASN ASN C . n 
A 1 809  ALA 809  809  809  ALA ALA C . n 
A 1 810  LEU 810  810  810  LEU LEU C . n 
A 1 811  GLY 811  811  811  GLY GLY C . n 
A 1 812  ASP 812  812  812  ASP ASP C . n 
A 1 813  PHE 813  813  813  PHE PHE C . n 
A 1 814  GLY 814  814  814  GLY GLY C . n 
A 1 815  ILE 815  815  815  ILE ILE C . n 
A 1 816  ARG 816  816  816  ARG ARG C . n 
A 1 817  LEU 817  817  817  LEU LEU C . n 
A 1 818  LEU 818  818  818  LEU LEU C . n 
A 1 819  CYS 819  819  819  CYS CYS C . n 
A 1 820  VAL 820  820  820  VAL VAL C . n 
A 1 821  GLY 821  821  821  GLY GLY C . n 
A 1 822  LEU 822  822  822  LEU LEU C . n 
A 1 823  LYS 823  823  823  LYS LYS C . n 
A 1 824  HIS 824  824  824  HIS HIS C . n 
A 1 825  LEU 825  825  825  LEU LEU C . n 
A 1 826  LEU 826  826  826  LEU LEU C . n 
A 1 827  CYS 827  827  827  CYS CYS C . n 
A 1 828  ASN 828  828  828  ASN ASN C . n 
A 1 829  LEU 829  829  829  LEU LEU C . n 
A 1 830  LYS 830  830  830  LYS LYS C . n 
A 1 831  LYS 831  831  831  LYS LYS C . n 
A 1 832  LEU 832  832  832  LEU LEU C . n 
A 1 833  TRP 833  833  833  TRP TRP C . n 
A 1 834  LEU 834  834  834  LEU LEU C . n 
A 1 835  VAL 835  835  835  VAL VAL C . n 
A 1 836  SER 836  836  836  SER SER C . n 
A 1 837  CYS 837  837  837  CYS CYS C . n 
A 1 838  CYS 838  838  838  CYS CYS C . n 
A 1 839  LEU 839  839  839  LEU LEU C . n 
A 1 840  THR 840  840  840  THR THR C . n 
A 1 841  SER 841  841  841  SER SER C . n 
A 1 842  ALA 842  842  842  ALA ALA C . n 
A 1 843  CYS 843  843  843  CYS CYS C . n 
A 1 844  CYS 844  844  844  CYS CYS C . n 
A 1 845  GLN 845  845  845  GLN GLN C . n 
A 1 846  ASP 846  846  846  ASP ASP C . n 
A 1 847  LEU 847  847  847  LEU LEU C . n 
A 1 848  ALA 848  848  848  ALA ALA C . n 
A 1 849  SER 849  849  849  SER SER C . n 
A 1 850  VAL 850  850  850  VAL VAL C . n 
A 1 851  LEU 851  851  851  LEU LEU C . n 
A 1 852  SER 852  852  852  SER SER C . n 
A 1 853  THR 853  853  853  THR THR C . n 
A 1 854  SER 854  854  854  SER SER C . n 
A 1 855  HIS 855  855  855  HIS HIS C . n 
A 1 856  SER 856  856  856  SER SER C . n 
A 1 857  LEU 857  857  857  LEU LEU C . n 
A 1 858  THR 858  858  858  THR THR C . n 
A 1 859  ARG 859  859  859  ARG ARG C . n 
A 1 860  LEU 860  860  860  LEU LEU C . n 
A 1 861  TYR 861  861  861  TYR TYR C . n 
A 1 862  VAL 862  862  862  VAL VAL C . n 
A 1 863  GLY 863  863  863  GLY GLY C . n 
A 1 864  GLU 864  864  864  GLU GLU C . n 
A 1 865  ASN 865  865  865  ASN ASN C . n 
A 1 866  ALA 866  866  866  ALA ALA C . n 
A 1 867  LEU 867  867  867  LEU LEU C . n 
A 1 868  GLY 868  868  868  GLY GLY C . n 
A 1 869  ASP 869  869  869  ASP ASP C . n 
A 1 870  SER 870  870  870  SER SER C . n 
A 1 871  GLY 871  871  871  GLY GLY C . n 
A 1 872  VAL 872  872  872  VAL VAL C . n 
A 1 873  ALA 873  873  873  ALA ALA C . n 
A 1 874  ILE 874  874  874  ILE ILE C . n 
A 1 875  LEU 875  875  875  LEU LEU C . n 
A 1 876  CYS 876  876  876  CYS CYS C . n 
A 1 877  GLU 877  877  877  GLU GLU C . n 
A 1 878  LYS 878  878  878  LYS LYS C . n 
A 1 879  ALA 879  879  879  ALA ALA C . n 
A 1 880  LYS 880  880  880  LYS LYS C . n 
A 1 881  ASN 881  881  881  ASN ASN C . n 
A 1 882  PRO 882  882  882  PRO PRO C . n 
A 1 883  GLN 883  883  883  GLN GLN C . n 
A 1 884  CYS 884  884  884  CYS CYS C . n 
A 1 885  ASN 885  885  885  ASN ASN C . n 
A 1 886  LEU 886  886  886  LEU LEU C . n 
A 1 887  GLN 887  887  887  GLN GLN C . n 
A 1 888  LYS 888  888  888  LYS LYS C . n 
A 1 889  LEU 889  889  889  LEU LEU C . n 
A 1 890  GLY 890  890  890  GLY GLY C . n 
A 1 891  LEU 891  891  891  LEU LEU C . n 
A 1 892  VAL 892  892  892  VAL VAL C . n 
A 1 893  ASN 893  893  893  ASN ASN C . n 
A 1 894  SER 894  894  894  SER SER C . n 
A 1 895  GLY 895  895  895  GLY GLY C . n 
A 1 896  LEU 896  896  896  LEU LEU C . n 
A 1 897  THR 897  897  897  THR THR C . n 
A 1 898  SER 898  898  898  SER SER C . n 
A 1 899  VAL 899  899  899  VAL VAL C . n 
A 1 900  CYS 900  900  900  CYS CYS C . n 
A 1 901  CYS 901  901  901  CYS CYS C . n 
A 1 902  SER 902  902  902  SER SER C . n 
A 1 903  ALA 903  903  903  ALA ALA C . n 
A 1 904  LEU 904  904  904  LEU LEU C . n 
A 1 905  SER 905  905  905  SER SER C . n 
A 1 906  SER 906  906  906  SER SER C . n 
A 1 907  VAL 907  907  907  VAL VAL C . n 
A 1 908  LEU 908  908  908  LEU LEU C . n 
A 1 909  SER 909  909  909  SER SER C . n 
A 1 910  THR 910  910  910  THR THR C . n 
A 1 911  ASN 911  911  911  ASN ASN C . n 
A 1 912  GLN 912  912  912  GLN GLN C . n 
A 1 913  ASN 913  913  913  ASN ASN C . n 
A 1 914  LEU 914  914  914  LEU LEU C . n 
A 1 915  THR 915  915  915  THR THR C . n 
A 1 916  HIS 916  916  916  HIS HIS C . n 
A 1 917  LEU 917  917  917  LEU LEU C . n 
A 1 918  TYR 918  918  918  TYR TYR C . n 
A 1 919  LEU 919  919  919  LEU LEU C . n 
A 1 920  ARG 920  920  920  ARG ARG C . n 
A 1 921  GLY 921  921  921  GLY GLY C . n 
A 1 922  ASN 922  922  922  ASN ASN C . n 
A 1 923  THR 923  923  923  THR THR C . n 
A 1 924  LEU 924  924  924  LEU LEU C . n 
A 1 925  GLY 925  925  925  GLY GLY C . n 
A 1 926  ASP 926  926  926  ASP ASP C . n 
A 1 927  LYS 927  927  927  LYS LYS C . n 
A 1 928  GLY 928  928  928  GLY GLY C . n 
A 1 929  ILE 929  929  929  ILE ILE C . n 
A 1 930  LYS 930  930  930  LYS LYS C . n 
A 1 931  LEU 931  931  931  LEU LEU C . n 
A 1 932  LEU 932  932  932  LEU LEU C . n 
A 1 933  CYS 933  933  933  CYS CYS C . n 
A 1 934  GLU 934  934  934  GLU GLU C . n 
A 1 935  GLY 935  935  935  GLY GLY C . n 
A 1 936  LEU 936  936  936  LEU LEU C . n 
A 1 937  LEU 937  937  937  LEU LEU C . n 
A 1 938  HIS 938  938  938  HIS HIS C . n 
A 1 939  PRO 939  939  939  PRO PRO C . n 
A 1 940  ASP 940  940  940  ASP ASP C . n 
A 1 941  CYS 941  941  941  CYS CYS C . n 
A 1 942  LYS 942  942  942  LYS LYS C . n 
A 1 943  LEU 943  943  943  LEU LEU C . n 
A 1 944  GLN 944  944  944  GLN GLN C . n 
A 1 945  VAL 945  945  945  VAL VAL C . n 
A 1 946  LEU 946  946  946  LEU LEU C . n 
A 1 947  GLU 947  947  947  GLU GLU C . n 
A 1 948  LEU 948  948  948  LEU LEU C . n 
A 1 949  ASP 949  949  949  ASP ASP C . n 
A 1 950  ASN 950  950  950  ASN ASN C . n 
A 1 951  CYS 951  951  951  CYS CYS C . n 
A 1 952  ASN 952  952  952  ASN ASN C . n 
A 1 953  LEU 953  953  953  LEU LEU C . n 
A 1 954  THR 954  954  954  THR THR C . n 
A 1 955  SER 955  955  955  SER SER C . n 
A 1 956  HIS 956  956  956  HIS HIS C . n 
A 1 957  CYS 957  957  957  CYS CYS C . n 
A 1 958  CYS 958  958  958  CYS CYS C . n 
A 1 959  TRP 959  959  959  TRP TRP C . n 
A 1 960  ASP 960  960  960  ASP ASP C . n 
A 1 961  LEU 961  961  961  LEU LEU C . n 
A 1 962  SER 962  962  962  SER SER C . n 
A 1 963  THR 963  963  963  THR THR C . n 
A 1 964  LEU 964  964  964  LEU LEU C . n 
A 1 965  LEU 965  965  965  LEU LEU C . n 
A 1 966  THR 966  966  966  THR THR C . n 
A 1 967  SER 967  967  967  SER SER C . n 
A 1 968  SER 968  968  968  SER SER C . n 
A 1 969  GLN 969  969  969  GLN GLN C . n 
A 1 970  SER 970  970  970  SER SER C . n 
A 1 971  LEU 971  971  971  LEU LEU C . n 
A 1 972  ARG 972  972  972  ARG ARG C . n 
A 1 973  LYS 973  973  973  LYS LYS C . n 
A 1 974  LEU 974  974  974  LEU LEU C . n 
A 1 975  SER 975  975  975  SER SER C . n 
A 1 976  LEU 976  976  976  LEU LEU C . n 
A 1 977  GLY 977  977  977  GLY GLY C . n 
A 1 978  ASN 978  978  978  ASN ASN C . n 
A 1 979  ASN 979  979  979  ASN ASN C . n 
A 1 980  ASP 980  980  980  ASP ASP C . n 
A 1 981  LEU 981  981  981  LEU LEU C . n 
A 1 982  GLY 982  982  982  GLY GLY C . n 
A 1 983  ASP 983  983  983  ASP ASP C . n 
A 1 984  LEU 984  984  984  LEU LEU C . n 
A 1 985  GLY 985  985  985  GLY GLY C . n 
A 1 986  VAL 986  986  986  VAL VAL C . n 
A 1 987  MET 987  987  987  MET MET C . n 
A 1 988  MET 988  988  988  MET MET C . n 
A 1 989  PHE 989  989  989  PHE PHE C . n 
A 1 990  CYS 990  990  990  CYS CYS C . n 
A 1 991  GLU 991  991  991  GLU GLU C . n 
A 1 992  VAL 992  992  992  VAL VAL C . n 
A 1 993  LEU 993  993  993  LEU LEU C . n 
A 1 994  LYS 994  994  994  LYS LYS C . n 
A 1 995  GLN 995  995  995  GLN GLN C . n 
A 1 996  GLN 996  996  996  GLN GLN C . n 
A 1 997  SER 997  997  997  SER SER C . n 
A 1 998  CYS 998  998  998  CYS CYS C . n 
A 1 999  LEU 999  999  999  LEU LEU C . n 
A 1 1000 LEU 1000 1000 1000 LEU LEU C . n 
A 1 1001 GLN 1001 1001 1001 GLN GLN C . n 
A 1 1002 ASN 1002 1002 1002 ASN ASN C . n 
A 1 1003 LEU 1003 1003 1003 LEU LEU C . n 
A 1 1004 GLY 1004 1004 1004 GLY GLY C . n 
A 1 1005 LEU 1005 1005 1005 LEU LEU C . n 
A 1 1006 SER 1006 1006 1006 SER SER C . n 
A 1 1007 GLU 1007 1007 1007 GLU GLU C . n 
A 1 1008 MET 1008 1008 1008 MET MET C . n 
A 1 1009 TYR 1009 1009 1009 TYR TYR C . n 
A 1 1010 PHE 1010 1010 1010 PHE PHE C . n 
A 1 1011 ASN 1011 1011 1011 ASN ASN C . n 
A 1 1012 TYR 1012 1012 1012 TYR TYR C . n 
A 1 1013 GLU 1013 1013 1013 GLU GLU C . n 
A 1 1014 THR 1014 1014 1014 THR THR C . n 
A 1 1015 LYS 1015 1015 1015 LYS LYS C . n 
A 1 1016 SER 1016 1016 1016 SER SER C . n 
A 1 1017 ALA 1017 1017 1017 ALA ALA C . n 
A 1 1018 LEU 1018 1018 1018 LEU LEU C . n 
A 1 1019 GLU 1019 1019 1019 GLU GLU C . n 
A 1 1020 THR 1020 1020 1020 THR THR C . n 
A 1 1021 LEU 1021 1021 1021 LEU LEU C . n 
A 1 1022 GLN 1022 1022 1022 GLN GLN C . n 
A 1 1023 GLU 1023 1023 1023 GLU GLU C . n 
A 1 1024 GLU 1024 1024 1024 GLU GLU C . n 
A 1 1025 LYS 1025 1025 1025 LYS LYS C . n 
A 1 1026 PRO 1026 1026 1026 PRO PRO C . n 
A 1 1027 GLU 1027 1027 1027 GLU GLU C . n 
A 1 1028 LEU 1028 1028 1028 LEU LEU C . n 
A 1 1029 THR 1029 1029 1029 THR THR C . n 
A 1 1030 VAL 1030 1030 1030 VAL VAL C . n 
A 1 1031 VAL 1031 1031 1031 VAL VAL C . n 
A 1 1032 PHE 1032 1032 1032 PHE PHE C . n 
A 1 1033 GLU 1033 1033 1033 GLU GLU C . n 
A 1 1034 PRO 1034 1034 1034 PRO PRO C . n 
A 1 1035 SER 1035 1035 1035 SER SER C . n 
A 1 1036 TRP 1036 1036 ?    ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BLP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BLP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ATP   1 1201 1201 ATP   ATP C . 
C 3 A1BLP 1 1202 1202 A1BLP LIG C . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MIE 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MIE 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MIE 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9MIE 
_struct.title                        'Human NLRP3 complex with compound 2 in the closed hexamer' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MIE 
_struct_keywords.text            'NLRP3, cryo-EM, small molecule inhibitor, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NLRP3_HUMAN 
_struct_ref.pdbx_db_accession          Q96P20 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MIE 
_struct_ref_seq.pdbx_strand_id                C 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 1036 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q96P20 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1036 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       1036 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 135  ? PHE A 148  ? ASP C 135  PHE C 148  1 ? 14 
HELX_P HELX_P2  AA2 LEU A 164  ? TYR A 168  ? LEU C 164  TYR C 168  5 ? 5  
HELX_P HELX_P3  AA3 GLY A 231  ? SER A 245  ? GLY C 231  SER C 245  1 ? 15 
HELX_P HELX_P4  AA4 GLY A 273  ? SER A 278  ? GLY C 273  SER C 278  1 ? 6  
HELX_P HELX_P5  AA5 LYS A 289  ? LYS A 293  ? LYS C 289  LYS C 293  5 ? 5  
HELX_P HELX_P6  AA6 PHE A 304  ? LEU A 307  ? PHE C 304  LEU C 307  5 ? 4  
HELX_P HELX_P7  AA7 ARG A 327  ? ARG A 337  ? ARG C 327  ARG C 337  1 ? 11 
HELX_P HELX_P8  AA8 ARG A 351  ? VAL A 353  ? ARG C 351  VAL C 353  5 ? 3  
HELX_P HELX_P9  AA9 ALA A 354  ? GLN A 359  ? ALA C 354  GLN C 359  1 ? 6  
HELX_P HELX_P10 AB1 SER A 374  ? PHE A 386  ? SER C 374  PHE C 386  1 ? 13 
HELX_P HELX_P11 AB2 ASP A 388  ? ASN A 402  ? ASP C 388  ASN C 402  1 ? 15 
HELX_P HELX_P12 AB3 ASN A 402  ? CYS A 409  ? ASN C 402  CYS C 409  1 ? 8  
HELX_P HELX_P13 AB4 ILE A 411  ? GLU A 427  ? ILE C 411  GLU C 427  1 ? 17 
HELX_P HELX_P14 AB5 THR A 438  ? GLN A 452  ? THR C 438  GLN C 452  1 ? 15 
HELX_P HELX_P15 AB6 HIS A 465  ? ASN A 479  ? HIS C 465  ASN C 479  1 ? 15 
HELX_P HELX_P16 AB7 GLU A 485  ? ASN A 491  ? GLU C 485  ASN C 491  1 ? 7  
HELX_P HELX_P17 AB8 ALA A 497  ? MET A 505  ? ALA C 497  MET C 505  1 ? 9  
HELX_P HELX_P18 AB9 HIS A 522  ? TYR A 533  ? HIS C 522  TYR C 533  1 ? 12 
HELX_P HELX_P19 AC1 TYR A 534  ? LEU A 536  ? TYR C 534  LEU C 536  5 ? 3  
HELX_P HELX_P20 AC2 ASP A 557  ? ASN A 564  ? ASP C 557  ASN C 564  1 ? 8  
HELX_P HELX_P21 AC3 LYS A 567  ? TYR A 572  ? LYS C 567  TYR C 572  5 ? 6  
HELX_P HELX_P22 AC4 LEU A 573  ? LEU A 583  ? LEU C 573  LEU C 583  1 ? 11 
HELX_P HELX_P23 AC5 LEU A 592  ? LEU A 596  ? LEU C 592  LEU C 596  5 ? 5  
HELX_P HELX_P24 AC6 SER A 597  ? ALA A 618  ? SER C 597  ALA C 618  1 ? 22 
HELX_P HELX_P25 AC7 LEU A 628  ? GLU A 636  ? LEU C 628  GLU C 636  1 ? 9  
HELX_P HELX_P26 AC8 GLU A 639  ? ASP A 648  ? GLU C 639  ASP C 648  1 ? 10 
HELX_P HELX_P27 AC9 THR A 659  ? ASN A 672  ? THR C 659  ASN C 672  1 ? 14 
HELX_P HELX_P28 AD1 SER A 727  ? PHE A 729  ? SER C 727  PHE C 729  5 ? 3  
HELX_P HELX_P29 AD2 CYS A 730  ? SER A 738  ? CYS C 730  SER C 738  1 ? 9  
HELX_P HELX_P30 AD3 GLY A 754  ? LEU A 765  ? GLY C 754  LEU C 765  1 ? 12 
HELX_P HELX_P31 AD4 GLU A 785  ? SER A 795  ? GLU C 785  SER C 795  1 ? 11 
HELX_P HELX_P32 AD5 GLY A 811  ? LYS A 823  ? GLY C 811  LYS C 823  1 ? 13 
HELX_P HELX_P33 AD6 THR A 840  ? ALA A 842  ? THR C 840  ALA C 842  5 ? 3  
HELX_P HELX_P34 AD7 CYS A 843  ? SER A 854  ? CYS C 843  SER C 854  1 ? 12 
HELX_P HELX_P35 AD8 GLY A 868  ? LYS A 880  ? GLY C 868  LYS C 880  1 ? 13 
HELX_P HELX_P36 AD9 THR A 897  ? VAL A 899  ? THR C 897  VAL C 899  5 ? 3  
HELX_P HELX_P37 AE1 CYS A 900  ? SER A 909  ? CYS C 900  SER C 909  1 ? 10 
HELX_P HELX_P38 AE2 LEU A 924  ? LEU A 937  ? LEU C 924  LEU C 937  1 ? 14 
HELX_P HELX_P39 AE3 THR A 954  ? HIS A 956  ? THR C 954  HIS C 956  5 ? 3  
HELX_P HELX_P40 AE4 CYS A 957  ? SER A 968  ? CYS C 957  SER C 968  1 ? 12 
HELX_P HELX_P41 AE5 GLY A 982  ? LEU A 993  ? GLY C 982  LEU C 993  1 ? 12 
HELX_P HELX_P42 AE6 ASN A 1011 ? LYS A 1025 ? ASN C 1011 LYS C 1025 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6  ? 
AA2 ? 2  ? 
AA3 ? 11 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 2  3  ? parallel      
AA1 3  4  ? parallel      
AA1 4  5  ? parallel      
AA1 5  6  ? parallel      
AA2 1  2  ? anti-parallel 
AA3 1  2  ? parallel      
AA3 2  3  ? parallel      
AA3 3  4  ? parallel      
AA3 4  5  ? parallel      
AA3 5  6  ? parallel      
AA3 6  7  ? parallel      
AA3 7  8  ? parallel      
AA3 8  9  ? parallel      
AA3 9  10 ? parallel      
AA3 10 11 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  LEU A 173 ? LYS A 175 ? LEU C 173 LYS C 175 
AA1 2  ARG A 366 ? ILE A 370 ? ARG C 366 ILE C 370 
AA1 3  THR A 221 ? GLN A 225 ? THR C 221 GLN C 225 
AA1 4  SER A 345 ? THR A 350 ? SER C 345 THR C 350 
AA1 5  ILE A 297 ? ASP A 302 ? ILE C 297 ASP C 302 
AA1 6  TYR A 255 ? HIS A 260 ? TYR C 255 HIS C 260 
AA2 1  PHE A 508 ? GLN A 509 ? PHE C 508 GLN C 509 
AA2 2  SER A 519 ? PHE A 520 ? SER C 519 PHE C 520 
AA3 1  LYS A 652 ? ILE A 655 ? LYS C 652 ILE C 655 
AA3 2  SER A 678 ? LEU A 681 ? SER C 678 LEU C 681 
AA3 3  GLU A 745 ? LEU A 748 ? GLU C 745 LEU C 748 
AA3 4  ARG A 774 ? LEU A 777 ? ARG C 774 LEU C 777 
AA3 5  GLU A 802 ? ASP A 804 ? GLU C 802 ASP C 804 
AA3 6  LYS A 831 ? TRP A 833 ? LYS C 831 TRP C 833 
AA3 7  ARG A 859 ? TYR A 861 ? ARG C 859 TYR C 861 
AA3 8  LYS A 888 ? LEU A 889 ? LYS C 888 LEU C 889 
AA3 9  HIS A 916 ? TYR A 918 ? HIS C 916 TYR C 918 
AA3 10 VAL A 945 ? LEU A 948 ? VAL C 945 LEU C 948 
AA3 11 LYS A 973 ? LEU A 976 ? LYS C 973 LEU C 976 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N ILE A 174 ? N ILE C 174 O GLU A 369 ? O GLU C 369 
AA1 2  3  O ARG A 366 ? O ARG C 366 N VAL A 223 ? N VAL C 223 
AA1 3  4  N PHE A 224 ? N PHE C 224 O ILE A 348 ? O ILE C 348 
AA1 4  5  O LEU A 347 ? O LEU C 347 N PHE A 299 ? N PHE C 299 
AA1 5  6  O LEU A 300 ? O LEU C 300 N ILE A 259 ? N ILE C 259 
AA2 1  2  N GLN A 509 ? N GLN C 509 O SER A 519 ? O SER C 519 
AA3 1  2  N ILE A 653 ? N ILE C 653 O SER A 680 ? O SER C 680 
AA3 2  3  N LEU A 679 ? N LEU C 679 O ASP A 747 ? O ASP C 747 
AA3 3  4  N LEU A 746 ? N LEU C 746 O ARG A 774 ? O ARG C 774 
AA3 4  5  N LEU A 775 ? N LEU C 775 O GLU A 802 ? O GLU C 802 
AA3 5  6  N LEU A 803 ? N LEU C 803 O LYS A 831 ? O LYS C 831 
AA3 6  7  N LEU A 832 ? N LEU C 832 O ARG A 859 ? O ARG C 859 
AA3 7  8  N LEU A 860 ? N LEU C 860 O LYS A 888 ? O LYS C 888 
AA3 8  9  N LEU A 889 ? N LEU C 889 O HIS A 916 ? O HIS C 916 
AA3 9  10 N LEU A 917 ? N LEU C 917 O VAL A 945 ? O VAL C 945 
AA3 10 11 N LEU A 948 ? N LEU C 948 O SER A 975 ? O SER C 975 
# 
_pdbx_entry_details.entry_id                   9MIE 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NH1 
_pdbx_validate_close_contact.auth_asym_id_1   C 
_pdbx_validate_close_contact.auth_comp_id_1   ARG 
_pdbx_validate_close_contact.auth_seq_id_1    578 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O1 
_pdbx_validate_close_contact.auth_asym_id_2   C 
_pdbx_validate_close_contact.auth_comp_id_2   A1BLP 
_pdbx_validate_close_contact.auth_seq_id_2    1202 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             1.44 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU C 164  ? ? 53.28   75.15   
2  1 LYS C 289  ? ? -106.08 -124.83 
3  1 CYS C 319  ? ? 57.45   79.32   
4  1 ASP C 321  ? ? 83.72   95.16   
5  1 ASP C 363  ? ? 63.55   -68.97  
6  1 LEU C 432  ? ? 66.67   63.07   
7  1 GLN C 434  ? ? -176.13 101.54  
8  1 ALA C 497  ? ? -155.05 -62.89  
9  1 ASN C 506  ? ? -47.88  106.82  
10 1 VAL C 512  ? ? -70.77  35.22   
11 1 SER C 555  ? ? -165.73 -66.84  
12 1 TYR C 572  ? ? 68.09   -10.68  
13 1 THR C 589  ? ? -131.72 -152.82 
14 1 SER C 590  ? ? -82.07  -159.22 
15 1 TYR C 591  ? ? 65.60   81.29   
16 1 LEU C 592  ? ? 73.26   -55.34  
17 1 GLN C 627  ? ? 69.12   -4.89   
18 1 CYS C 633  ? ? -67.21  0.32    
19 1 SER C 783  ? ? -108.14 -167.82 
20 1 ALA C 809  ? ? -95.65  52.70   
21 1 ALA C 866  ? ? -98.41  52.43   
22 1 THR C 923  ? ? -119.46 62.05   
23 1 ASN C 950  ? ? -29.78  96.12   
24 1 LEU C 1005 ? ? 70.71   30.48   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9MIE 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9MIE 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.93 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               407363 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human NLRP3 complex with compound 2' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9MIE 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2400 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9MIE 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9MIE 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 C MET 1    ? A MET 1    
2   1 Y 1 C LYS 2    ? A LYS 2    
3   1 Y 1 C MET 3    ? A MET 3    
4   1 Y 1 C ALA 4    ? A ALA 4    
5   1 Y 1 C SER 5    ? A SER 5    
6   1 Y 1 C THR 6    ? A THR 6    
7   1 Y 1 C ARG 7    ? A ARG 7    
8   1 Y 1 C CYS 8    ? A CYS 8    
9   1 Y 1 C LYS 9    ? A LYS 9    
10  1 Y 1 C LEU 10   ? A LEU 10   
11  1 Y 1 C ALA 11   ? A ALA 11   
12  1 Y 1 C ARG 12   ? A ARG 12   
13  1 Y 1 C TYR 13   ? A TYR 13   
14  1 Y 1 C LEU 14   ? A LEU 14   
15  1 Y 1 C GLU 15   ? A GLU 15   
16  1 Y 1 C ASP 16   ? A ASP 16   
17  1 Y 1 C LEU 17   ? A LEU 17   
18  1 Y 1 C GLU 18   ? A GLU 18   
19  1 Y 1 C ASP 19   ? A ASP 19   
20  1 Y 1 C VAL 20   ? A VAL 20   
21  1 Y 1 C ASP 21   ? A ASP 21   
22  1 Y 1 C LEU 22   ? A LEU 22   
23  1 Y 1 C LYS 23   ? A LYS 23   
24  1 Y 1 C LYS 24   ? A LYS 24   
25  1 Y 1 C PHE 25   ? A PHE 25   
26  1 Y 1 C LYS 26   ? A LYS 26   
27  1 Y 1 C MET 27   ? A MET 27   
28  1 Y 1 C HIS 28   ? A HIS 28   
29  1 Y 1 C LEU 29   ? A LEU 29   
30  1 Y 1 C GLU 30   ? A GLU 30   
31  1 Y 1 C ASP 31   ? A ASP 31   
32  1 Y 1 C TYR 32   ? A TYR 32   
33  1 Y 1 C PRO 33   ? A PRO 33   
34  1 Y 1 C PRO 34   ? A PRO 34   
35  1 Y 1 C GLN 35   ? A GLN 35   
36  1 Y 1 C LYS 36   ? A LYS 36   
37  1 Y 1 C GLY 37   ? A GLY 37   
38  1 Y 1 C CYS 38   ? A CYS 38   
39  1 Y 1 C ILE 39   ? A ILE 39   
40  1 Y 1 C PRO 40   ? A PRO 40   
41  1 Y 1 C LEU 41   ? A LEU 41   
42  1 Y 1 C PRO 42   ? A PRO 42   
43  1 Y 1 C ARG 43   ? A ARG 43   
44  1 Y 1 C GLY 44   ? A GLY 44   
45  1 Y 1 C GLN 45   ? A GLN 45   
46  1 Y 1 C THR 46   ? A THR 46   
47  1 Y 1 C GLU 47   ? A GLU 47   
48  1 Y 1 C LYS 48   ? A LYS 48   
49  1 Y 1 C ALA 49   ? A ALA 49   
50  1 Y 1 C ASP 50   ? A ASP 50   
51  1 Y 1 C HIS 51   ? A HIS 51   
52  1 Y 1 C VAL 52   ? A VAL 52   
53  1 Y 1 C ASP 53   ? A ASP 53   
54  1 Y 1 C LEU 54   ? A LEU 54   
55  1 Y 1 C ALA 55   ? A ALA 55   
56  1 Y 1 C THR 56   ? A THR 56   
57  1 Y 1 C LEU 57   ? A LEU 57   
58  1 Y 1 C MET 58   ? A MET 58   
59  1 Y 1 C ILE 59   ? A ILE 59   
60  1 Y 1 C ASP 60   ? A ASP 60   
61  1 Y 1 C PHE 61   ? A PHE 61   
62  1 Y 1 C ASN 62   ? A ASN 62   
63  1 Y 1 C GLY 63   ? A GLY 63   
64  1 Y 1 C GLU 64   ? A GLU 64   
65  1 Y 1 C GLU 65   ? A GLU 65   
66  1 Y 1 C LYS 66   ? A LYS 66   
67  1 Y 1 C ALA 67   ? A ALA 67   
68  1 Y 1 C TRP 68   ? A TRP 68   
69  1 Y 1 C ALA 69   ? A ALA 69   
70  1 Y 1 C MET 70   ? A MET 70   
71  1 Y 1 C ALA 71   ? A ALA 71   
72  1 Y 1 C VAL 72   ? A VAL 72   
73  1 Y 1 C TRP 73   ? A TRP 73   
74  1 Y 1 C ILE 74   ? A ILE 74   
75  1 Y 1 C PHE 75   ? A PHE 75   
76  1 Y 1 C ALA 76   ? A ALA 76   
77  1 Y 1 C ALA 77   ? A ALA 77   
78  1 Y 1 C ILE 78   ? A ILE 78   
79  1 Y 1 C ASN 79   ? A ASN 79   
80  1 Y 1 C ARG 80   ? A ARG 80   
81  1 Y 1 C ARG 81   ? A ARG 81   
82  1 Y 1 C ASP 82   ? A ASP 82   
83  1 Y 1 C LEU 83   ? A LEU 83   
84  1 Y 1 C TYR 84   ? A TYR 84   
85  1 Y 1 C GLU 85   ? A GLU 85   
86  1 Y 1 C LYS 86   ? A LYS 86   
87  1 Y 1 C ALA 87   ? A ALA 87   
88  1 Y 1 C LYS 88   ? A LYS 88   
89  1 Y 1 C ARG 89   ? A ARG 89   
90  1 Y 1 C ASP 90   ? A ASP 90   
91  1 Y 1 C GLU 91   ? A GLU 91   
92  1 Y 1 C PRO 92   ? A PRO 92   
93  1 Y 1 C LYS 93   ? A LYS 93   
94  1 Y 1 C TRP 94   ? A TRP 94   
95  1 Y 1 C GLY 95   ? A GLY 95   
96  1 Y 1 C SER 96   ? A SER 96   
97  1 Y 1 C ASP 97   ? A ASP 97   
98  1 Y 1 C ASN 98   ? A ASN 98   
99  1 Y 1 C ALA 99   ? A ALA 99   
100 1 Y 1 C ARG 100  ? A ARG 100  
101 1 Y 1 C VAL 101  ? A VAL 101  
102 1 Y 1 C SER 102  ? A SER 102  
103 1 Y 1 C ASN 103  ? A ASN 103  
104 1 Y 1 C PRO 104  ? A PRO 104  
105 1 Y 1 C THR 105  ? A THR 105  
106 1 Y 1 C VAL 106  ? A VAL 106  
107 1 Y 1 C ILE 107  ? A ILE 107  
108 1 Y 1 C CYS 108  ? A CYS 108  
109 1 Y 1 C GLN 109  ? A GLN 109  
110 1 Y 1 C GLU 110  ? A GLU 110  
111 1 Y 1 C ASP 111  ? A ASP 111  
112 1 Y 1 C SER 112  ? A SER 112  
113 1 Y 1 C ILE 113  ? A ILE 113  
114 1 Y 1 C GLU 114  ? A GLU 114  
115 1 Y 1 C GLU 115  ? A GLU 115  
116 1 Y 1 C GLU 116  ? A GLU 116  
117 1 Y 1 C TRP 117  ? A TRP 117  
118 1 Y 1 C MET 118  ? A MET 118  
119 1 Y 1 C GLY 119  ? A GLY 119  
120 1 Y 1 C LEU 120  ? A LEU 120  
121 1 Y 1 C LEU 121  ? A LEU 121  
122 1 Y 1 C GLU 122  ? A GLU 122  
123 1 Y 1 C TYR 123  ? A TYR 123  
124 1 Y 1 C LEU 124  ? A LEU 124  
125 1 Y 1 C SER 125  ? A SER 125  
126 1 Y 1 C ARG 126  ? A ARG 126  
127 1 Y 1 C ILE 127  ? A ILE 127  
128 1 Y 1 C SER 128  ? A SER 128  
129 1 Y 1 C ILE 129  ? A ILE 129  
130 1 Y 1 C CYS 130  ? A CYS 130  
131 1 Y 1 C LYS 131  ? A LYS 131  
132 1 Y 1 C MET 132  ? A MET 132  
133 1 Y 1 C HIS 177  ? A HIS 177  
134 1 Y 1 C ARG 178  ? A ARG 178  
135 1 Y 1 C SER 179  ? A SER 179  
136 1 Y 1 C GLN 180  ? A GLN 180  
137 1 Y 1 C GLN 181  ? A GLN 181  
138 1 Y 1 C GLU 182  ? A GLU 182  
139 1 Y 1 C ARG 183  ? A ARG 183  
140 1 Y 1 C GLU 184  ? A GLU 184  
141 1 Y 1 C GLN 185  ? A GLN 185  
142 1 Y 1 C GLU 186  ? A GLU 186  
143 1 Y 1 C LEU 187  ? A LEU 187  
144 1 Y 1 C LEU 188  ? A LEU 188  
145 1 Y 1 C ALA 189  ? A ALA 189  
146 1 Y 1 C ILE 190  ? A ILE 190  
147 1 Y 1 C GLY 191  ? A GLY 191  
148 1 Y 1 C LYS 192  ? A LYS 192  
149 1 Y 1 C THR 193  ? A THR 193  
150 1 Y 1 C LYS 194  ? A LYS 194  
151 1 Y 1 C THR 195  ? A THR 195  
152 1 Y 1 C CYS 196  ? A CYS 196  
153 1 Y 1 C GLU 197  ? A GLU 197  
154 1 Y 1 C SER 198  ? A SER 198  
155 1 Y 1 C PRO 199  ? A PRO 199  
156 1 Y 1 C VAL 200  ? A VAL 200  
157 1 Y 1 C ARG 454  ? A ARG 454  
158 1 Y 1 C GLY 455  ? A GLY 455  
159 1 Y 1 C GLY 456  ? A GLY 456  
160 1 Y 1 C SER 457  ? A SER 457  
161 1 Y 1 C GLN 458  ? A GLN 458  
162 1 Y 1 C GLU 459  ? A GLU 459  
163 1 Y 1 C HIS 460  ? A HIS 460  
164 1 Y 1 C GLY 461  ? A GLY 461  
165 1 Y 1 C GLU 538  ? A GLU 538  
166 1 Y 1 C GLU 539  ? A GLU 539  
167 1 Y 1 C LYS 540  ? A LYS 540  
168 1 Y 1 C GLU 541  ? A GLU 541  
169 1 Y 1 C GLY 542  ? A GLY 542  
170 1 Y 1 C ARG 543  ? A ARG 543  
171 1 Y 1 C THR 544  ? A THR 544  
172 1 Y 1 C ASN 545  ? A ASN 545  
173 1 Y 1 C VAL 546  ? A VAL 546  
174 1 Y 1 C PRO 547  ? A PRO 547  
175 1 Y 1 C GLY 548  ? A GLY 548  
176 1 Y 1 C SER 549  ? A SER 549  
177 1 Y 1 C ARG 550  ? A ARG 550  
178 1 Y 1 C LEU 551  ? A LEU 551  
179 1 Y 1 C LYS 552  ? A LYS 552  
180 1 Y 1 C MET 687  ? A MET 687  
181 1 Y 1 C PRO 688  ? A PRO 688  
182 1 Y 1 C LYS 689  ? A LYS 689  
183 1 Y 1 C GLU 690  ? A GLU 690  
184 1 Y 1 C GLU 691  ? A GLU 691  
185 1 Y 1 C GLU 692  ? A GLU 692  
186 1 Y 1 C GLU 693  ? A GLU 693  
187 1 Y 1 C GLU 694  ? A GLU 694  
188 1 Y 1 C GLU 695  ? A GLU 695  
189 1 Y 1 C LYS 696  ? A LYS 696  
190 1 Y 1 C GLU 697  ? A GLU 697  
191 1 Y 1 C GLY 698  ? A GLY 698  
192 1 Y 1 C ARG 699  ? A ARG 699  
193 1 Y 1 C HIS 700  ? A HIS 700  
194 1 Y 1 C LEU 701  ? A LEU 701  
195 1 Y 1 C ASP 702  ? A ASP 702  
196 1 Y 1 C MET 703  ? A MET 703  
197 1 Y 1 C VAL 704  ? A VAL 704  
198 1 Y 1 C GLN 705  ? A GLN 705  
199 1 Y 1 C CYS 706  ? A CYS 706  
200 1 Y 1 C VAL 707  ? A VAL 707  
201 1 Y 1 C LEU 708  ? A LEU 708  
202 1 Y 1 C PRO 709  ? A PRO 709  
203 1 Y 1 C SER 710  ? A SER 710  
204 1 Y 1 C SER 711  ? A SER 711  
205 1 Y 1 C SER 712  ? A SER 712  
206 1 Y 1 C HIS 713  ? A HIS 713  
207 1 Y 1 C ALA 714  ? A ALA 714  
208 1 Y 1 C ALA 715  ? A ALA 715  
209 1 Y 1 C CYS 716  ? A CYS 716  
210 1 Y 1 C SER 717  ? A SER 717  
211 1 Y 1 C HIS 718  ? A HIS 718  
212 1 Y 1 C GLY 719  ? A GLY 719  
213 1 Y 1 C LEU 720  ? A LEU 720  
214 1 Y 1 C VAL 721  ? A VAL 721  
215 1 Y 1 C ASN 722  ? A ASN 722  
216 1 Y 1 C SER 723  ? A SER 723  
217 1 Y 1 C HIS 724  ? A HIS 724  
218 1 Y 1 C TRP 1036 ? A TRP 1036 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BLP N1     N N N 1   
A1BLP N3     N Y N 2   
A1BLP C4     C N N 3   
A1BLP C5     C N R 4   
A1BLP C6     C N N 5   
A1BLP C7     C Y N 6   
A1BLP C8     C Y N 7   
A1BLP C10    C N N 8   
A1BLP C13    C Y N 9   
A1BLP C15    C Y N 10  
A1BLP C17    C Y N 11  
A1BLP C20    C N N 12  
A1BLP C1     C N N 13  
A1BLP O1     O N N 14  
A1BLP C2     C N N 15  
A1BLP N2     N N N 16  
A1BLP C3     C N N 17  
A1BLP N4     N Y N 18  
A1BLP C9     C Y N 19  
A1BLP C11    C N N 20  
A1BLP C12    C N N 21  
A1BLP C14    C Y N 22  
A1BLP C16    C Y N 23  
A1BLP C18    C Y N 24  
A1BLP C19    C Y N 25  
A1BLP F1     F N N 26  
A1BLP F2     F N N 27  
A1BLP F3     F N N 28  
A1BLP H2     H N N 29  
A1BLP H3     H N N 30  
A1BLP H4     H N N 31  
A1BLP H5     H N N 32  
A1BLP H6     H N N 33  
A1BLP H7     H N N 34  
A1BLP H8     H N N 35  
A1BLP H9     H N N 36  
A1BLP H10    H N N 37  
A1BLP H11    H N N 38  
A1BLP H12    H N N 39  
A1BLP H13    H N N 40  
A1BLP H14    H N N 41  
A1BLP H15    H N N 42  
A1BLP H16    H N N 43  
A1BLP H17    H N N 44  
A1BLP H18    H N N 45  
A1BLP H19    H N N 46  
A1BLP H20    H N N 47  
A1BLP H21    H N N 48  
A1BLP H22    H N N 49  
A1BLP H23    H N N 50  
A1BLP H24    H N N 51  
ALA   N      N N N 52  
ALA   CA     C N S 53  
ALA   C      C N N 54  
ALA   O      O N N 55  
ALA   CB     C N N 56  
ALA   OXT    O N N 57  
ALA   H      H N N 58  
ALA   H2     H N N 59  
ALA   HA     H N N 60  
ALA   HB1    H N N 61  
ALA   HB2    H N N 62  
ALA   HB3    H N N 63  
ALA   HXT    H N N 64  
ARG   N      N N N 65  
ARG   CA     C N S 66  
ARG   C      C N N 67  
ARG   O      O N N 68  
ARG   CB     C N N 69  
ARG   CG     C N N 70  
ARG   CD     C N N 71  
ARG   NE     N N N 72  
ARG   CZ     C N N 73  
ARG   NH1    N N N 74  
ARG   NH2    N N N 75  
ARG   OXT    O N N 76  
ARG   H      H N N 77  
ARG   H2     H N N 78  
ARG   HA     H N N 79  
ARG   HB2    H N N 80  
ARG   HB3    H N N 81  
ARG   HG2    H N N 82  
ARG   HG3    H N N 83  
ARG   HD2    H N N 84  
ARG   HD3    H N N 85  
ARG   HE     H N N 86  
ARG   HH11   H N N 87  
ARG   HH12   H N N 88  
ARG   HH21   H N N 89  
ARG   HH22   H N N 90  
ARG   HXT    H N N 91  
ASN   N      N N N 92  
ASN   CA     C N S 93  
ASN   C      C N N 94  
ASN   O      O N N 95  
ASN   CB     C N N 96  
ASN   CG     C N N 97  
ASN   OD1    O N N 98  
ASN   ND2    N N N 99  
ASN   OXT    O N N 100 
ASN   H      H N N 101 
ASN   H2     H N N 102 
ASN   HA     H N N 103 
ASN   HB2    H N N 104 
ASN   HB3    H N N 105 
ASN   HD21   H N N 106 
ASN   HD22   H N N 107 
ASN   HXT    H N N 108 
ASP   N      N N N 109 
ASP   CA     C N S 110 
ASP   C      C N N 111 
ASP   O      O N N 112 
ASP   CB     C N N 113 
ASP   CG     C N N 114 
ASP   OD1    O N N 115 
ASP   OD2    O N N 116 
ASP   OXT    O N N 117 
ASP   H      H N N 118 
ASP   H2     H N N 119 
ASP   HA     H N N 120 
ASP   HB2    H N N 121 
ASP   HB3    H N N 122 
ASP   HD2    H N N 123 
ASP   HXT    H N N 124 
ATP   PG     P N N 125 
ATP   O1G    O N N 126 
ATP   O2G    O N N 127 
ATP   O3G    O N N 128 
ATP   PB     P N R 129 
ATP   O1B    O N N 130 
ATP   O2B    O N N 131 
ATP   O3B    O N N 132 
ATP   PA     P N R 133 
ATP   O1A    O N N 134 
ATP   O2A    O N N 135 
ATP   O3A    O N N 136 
ATP   "O5'"  O N N 137 
ATP   "C5'"  C N N 138 
ATP   "C4'"  C N R 139 
ATP   "O4'"  O N N 140 
ATP   "C3'"  C N S 141 
ATP   "O3'"  O N N 142 
ATP   "C2'"  C N R 143 
ATP   "O2'"  O N N 144 
ATP   "C1'"  C N R 145 
ATP   N9     N Y N 146 
ATP   C8     C Y N 147 
ATP   N7     N Y N 148 
ATP   C5     C Y N 149 
ATP   C6     C Y N 150 
ATP   N6     N N N 151 
ATP   N1     N Y N 152 
ATP   C2     C Y N 153 
ATP   N3     N Y N 154 
ATP   C4     C Y N 155 
ATP   HOG2   H N N 156 
ATP   HOG3   H N N 157 
ATP   HOB2   H N N 158 
ATP   HOA2   H N N 159 
ATP   "H5'1" H N N 160 
ATP   "H5'2" H N N 161 
ATP   "H4'"  H N N 162 
ATP   "H3'"  H N N 163 
ATP   "HO3'" H N N 164 
ATP   "H2'"  H N N 165 
ATP   "HO2'" H N N 166 
ATP   "H1'"  H N N 167 
ATP   H8     H N N 168 
ATP   HN61   H N N 169 
ATP   HN62   H N N 170 
ATP   H2     H N N 171 
CYS   N      N N N 172 
CYS   CA     C N R 173 
CYS   C      C N N 174 
CYS   O      O N N 175 
CYS   CB     C N N 176 
CYS   SG     S N N 177 
CYS   OXT    O N N 178 
CYS   H      H N N 179 
CYS   H2     H N N 180 
CYS   HA     H N N 181 
CYS   HB2    H N N 182 
CYS   HB3    H N N 183 
CYS   HG     H N N 184 
CYS   HXT    H N N 185 
GLN   N      N N N 186 
GLN   CA     C N S 187 
GLN   C      C N N 188 
GLN   O      O N N 189 
GLN   CB     C N N 190 
GLN   CG     C N N 191 
GLN   CD     C N N 192 
GLN   OE1    O N N 193 
GLN   NE2    N N N 194 
GLN   OXT    O N N 195 
GLN   H      H N N 196 
GLN   H2     H N N 197 
GLN   HA     H N N 198 
GLN   HB2    H N N 199 
GLN   HB3    H N N 200 
GLN   HG2    H N N 201 
GLN   HG3    H N N 202 
GLN   HE21   H N N 203 
GLN   HE22   H N N 204 
GLN   HXT    H N N 205 
GLU   N      N N N 206 
GLU   CA     C N S 207 
GLU   C      C N N 208 
GLU   O      O N N 209 
GLU   CB     C N N 210 
GLU   CG     C N N 211 
GLU   CD     C N N 212 
GLU   OE1    O N N 213 
GLU   OE2    O N N 214 
GLU   OXT    O N N 215 
GLU   H      H N N 216 
GLU   H2     H N N 217 
GLU   HA     H N N 218 
GLU   HB2    H N N 219 
GLU   HB3    H N N 220 
GLU   HG2    H N N 221 
GLU   HG3    H N N 222 
GLU   HE2    H N N 223 
GLU   HXT    H N N 224 
GLY   N      N N N 225 
GLY   CA     C N N 226 
GLY   C      C N N 227 
GLY   O      O N N 228 
GLY   OXT    O N N 229 
GLY   H      H N N 230 
GLY   H2     H N N 231 
GLY   HA2    H N N 232 
GLY   HA3    H N N 233 
GLY   HXT    H N N 234 
HIS   N      N N N 235 
HIS   CA     C N S 236 
HIS   C      C N N 237 
HIS   O      O N N 238 
HIS   CB     C N N 239 
HIS   CG     C Y N 240 
HIS   ND1    N Y N 241 
HIS   CD2    C Y N 242 
HIS   CE1    C Y N 243 
HIS   NE2    N Y N 244 
HIS   OXT    O N N 245 
HIS   H      H N N 246 
HIS   H2     H N N 247 
HIS   HA     H N N 248 
HIS   HB2    H N N 249 
HIS   HB3    H N N 250 
HIS   HD1    H N N 251 
HIS   HD2    H N N 252 
HIS   HE1    H N N 253 
HIS   HE2    H N N 254 
HIS   HXT    H N N 255 
ILE   N      N N N 256 
ILE   CA     C N S 257 
ILE   C      C N N 258 
ILE   O      O N N 259 
ILE   CB     C N S 260 
ILE   CG1    C N N 261 
ILE   CG2    C N N 262 
ILE   CD1    C N N 263 
ILE   OXT    O N N 264 
ILE   H      H N N 265 
ILE   H2     H N N 266 
ILE   HA     H N N 267 
ILE   HB     H N N 268 
ILE   HG12   H N N 269 
ILE   HG13   H N N 270 
ILE   HG21   H N N 271 
ILE   HG22   H N N 272 
ILE   HG23   H N N 273 
ILE   HD11   H N N 274 
ILE   HD12   H N N 275 
ILE   HD13   H N N 276 
ILE   HXT    H N N 277 
LEU   N      N N N 278 
LEU   CA     C N S 279 
LEU   C      C N N 280 
LEU   O      O N N 281 
LEU   CB     C N N 282 
LEU   CG     C N N 283 
LEU   CD1    C N N 284 
LEU   CD2    C N N 285 
LEU   OXT    O N N 286 
LEU   H      H N N 287 
LEU   H2     H N N 288 
LEU   HA     H N N 289 
LEU   HB2    H N N 290 
LEU   HB3    H N N 291 
LEU   HG     H N N 292 
LEU   HD11   H N N 293 
LEU   HD12   H N N 294 
LEU   HD13   H N N 295 
LEU   HD21   H N N 296 
LEU   HD22   H N N 297 
LEU   HD23   H N N 298 
LEU   HXT    H N N 299 
LYS   N      N N N 300 
LYS   CA     C N S 301 
LYS   C      C N N 302 
LYS   O      O N N 303 
LYS   CB     C N N 304 
LYS   CG     C N N 305 
LYS   CD     C N N 306 
LYS   CE     C N N 307 
LYS   NZ     N N N 308 
LYS   OXT    O N N 309 
LYS   H      H N N 310 
LYS   H2     H N N 311 
LYS   HA     H N N 312 
LYS   HB2    H N N 313 
LYS   HB3    H N N 314 
LYS   HG2    H N N 315 
LYS   HG3    H N N 316 
LYS   HD2    H N N 317 
LYS   HD3    H N N 318 
LYS   HE2    H N N 319 
LYS   HE3    H N N 320 
LYS   HZ1    H N N 321 
LYS   HZ2    H N N 322 
LYS   HZ3    H N N 323 
LYS   HXT    H N N 324 
MET   N      N N N 325 
MET   CA     C N S 326 
MET   C      C N N 327 
MET   O      O N N 328 
MET   CB     C N N 329 
MET   CG     C N N 330 
MET   SD     S N N 331 
MET   CE     C N N 332 
MET   OXT    O N N 333 
MET   H      H N N 334 
MET   H2     H N N 335 
MET   HA     H N N 336 
MET   HB2    H N N 337 
MET   HB3    H N N 338 
MET   HG2    H N N 339 
MET   HG3    H N N 340 
MET   HE1    H N N 341 
MET   HE2    H N N 342 
MET   HE3    H N N 343 
MET   HXT    H N N 344 
PHE   N      N N N 345 
PHE   CA     C N S 346 
PHE   C      C N N 347 
PHE   O      O N N 348 
PHE   CB     C N N 349 
PHE   CG     C Y N 350 
PHE   CD1    C Y N 351 
PHE   CD2    C Y N 352 
PHE   CE1    C Y N 353 
PHE   CE2    C Y N 354 
PHE   CZ     C Y N 355 
PHE   OXT    O N N 356 
PHE   H      H N N 357 
PHE   H2     H N N 358 
PHE   HA     H N N 359 
PHE   HB2    H N N 360 
PHE   HB3    H N N 361 
PHE   HD1    H N N 362 
PHE   HD2    H N N 363 
PHE   HE1    H N N 364 
PHE   HE2    H N N 365 
PHE   HZ     H N N 366 
PHE   HXT    H N N 367 
PRO   N      N N N 368 
PRO   CA     C N S 369 
PRO   C      C N N 370 
PRO   O      O N N 371 
PRO   CB     C N N 372 
PRO   CG     C N N 373 
PRO   CD     C N N 374 
PRO   OXT    O N N 375 
PRO   H      H N N 376 
PRO   HA     H N N 377 
PRO   HB2    H N N 378 
PRO   HB3    H N N 379 
PRO   HG2    H N N 380 
PRO   HG3    H N N 381 
PRO   HD2    H N N 382 
PRO   HD3    H N N 383 
PRO   HXT    H N N 384 
SER   N      N N N 385 
SER   CA     C N S 386 
SER   C      C N N 387 
SER   O      O N N 388 
SER   CB     C N N 389 
SER   OG     O N N 390 
SER   OXT    O N N 391 
SER   H      H N N 392 
SER   H2     H N N 393 
SER   HA     H N N 394 
SER   HB2    H N N 395 
SER   HB3    H N N 396 
SER   HG     H N N 397 
SER   HXT    H N N 398 
THR   N      N N N 399 
THR   CA     C N S 400 
THR   C      C N N 401 
THR   O      O N N 402 
THR   CB     C N R 403 
THR   OG1    O N N 404 
THR   CG2    C N N 405 
THR   OXT    O N N 406 
THR   H      H N N 407 
THR   H2     H N N 408 
THR   HA     H N N 409 
THR   HB     H N N 410 
THR   HG1    H N N 411 
THR   HG21   H N N 412 
THR   HG22   H N N 413 
THR   HG23   H N N 414 
THR   HXT    H N N 415 
TRP   N      N N N 416 
TRP   CA     C N S 417 
TRP   C      C N N 418 
TRP   O      O N N 419 
TRP   CB     C N N 420 
TRP   CG     C Y N 421 
TRP   CD1    C Y N 422 
TRP   CD2    C Y N 423 
TRP   NE1    N Y N 424 
TRP   CE2    C Y N 425 
TRP   CE3    C Y N 426 
TRP   CZ2    C Y N 427 
TRP   CZ3    C Y N 428 
TRP   CH2    C Y N 429 
TRP   OXT    O N N 430 
TRP   H      H N N 431 
TRP   H2     H N N 432 
TRP   HA     H N N 433 
TRP   HB2    H N N 434 
TRP   HB3    H N N 435 
TRP   HD1    H N N 436 
TRP   HE1    H N N 437 
TRP   HE3    H N N 438 
TRP   HZ2    H N N 439 
TRP   HZ3    H N N 440 
TRP   HH2    H N N 441 
TRP   HXT    H N N 442 
TYR   N      N N N 443 
TYR   CA     C N S 444 
TYR   C      C N N 445 
TYR   O      O N N 446 
TYR   CB     C N N 447 
TYR   CG     C Y N 448 
TYR   CD1    C Y N 449 
TYR   CD2    C Y N 450 
TYR   CE1    C Y N 451 
TYR   CE2    C Y N 452 
TYR   CZ     C Y N 453 
TYR   OH     O N N 454 
TYR   OXT    O N N 455 
TYR   H      H N N 456 
TYR   H2     H N N 457 
TYR   HA     H N N 458 
TYR   HB2    H N N 459 
TYR   HB3    H N N 460 
TYR   HD1    H N N 461 
TYR   HD2    H N N 462 
TYR   HE1    H N N 463 
TYR   HE2    H N N 464 
TYR   HH     H N N 465 
TYR   HXT    H N N 466 
VAL   N      N N N 467 
VAL   CA     C N S 468 
VAL   C      C N N 469 
VAL   O      O N N 470 
VAL   CB     C N N 471 
VAL   CG1    C N N 472 
VAL   CG2    C N N 473 
VAL   OXT    O N N 474 
VAL   H      H N N 475 
VAL   H2     H N N 476 
VAL   HA     H N N 477 
VAL   HB     H N N 478 
VAL   HG11   H N N 479 
VAL   HG12   H N N 480 
VAL   HG13   H N N 481 
VAL   HG21   H N N 482 
VAL   HG22   H N N 483 
VAL   HG23   H N N 484 
VAL   HXT    H N N 485 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BLP C11   C10    sing N N 1   
A1BLP C11   C12    sing N N 2   
A1BLP C10   C9     sing N N 3   
A1BLP C12   C13    sing N N 4   
A1BLP C9    C13    doub Y N 5   
A1BLP C9    C8     sing Y N 6   
A1BLP C13   C7     sing Y N 7   
A1BLP C15   C16    doub Y N 8   
A1BLP C15   C14    sing Y N 9   
A1BLP C16   C17    sing Y N 10  
A1BLP C7    N2     sing N N 11  
A1BLP C7    N3     doub Y N 12  
A1BLP C8    C14    sing N N 13  
A1BLP C8    N4     doub Y N 14  
A1BLP N2    C5     sing N N 15  
A1BLP C14   C19    doub Y N 16  
A1BLP F2    C20    sing N N 17  
A1BLP F1    C20    sing N N 18  
A1BLP C4    C3     sing N N 19  
A1BLP C4    C5     sing N N 20  
A1BLP C17   C20    sing N N 21  
A1BLP C17   C18    doub Y N 22  
A1BLP C20   F3     sing N N 23  
A1BLP C3    C2     sing N N 24  
A1BLP C5    C6     sing N N 25  
A1BLP N4    N3     sing Y N 26  
A1BLP C19   C18    sing Y N 27  
A1BLP C19   O1     sing N N 28  
A1BLP C1    N1     sing N N 29  
A1BLP C2    N1     sing N N 30  
A1BLP C6    N1     sing N N 31  
A1BLP C4    H2     sing N N 32  
A1BLP C4    H3     sing N N 33  
A1BLP C5    H4     sing N N 34  
A1BLP C6    H5     sing N N 35  
A1BLP C6    H6     sing N N 36  
A1BLP C10   H7     sing N N 37  
A1BLP C10   H8     sing N N 38  
A1BLP C15   H9     sing N N 39  
A1BLP C1    H10    sing N N 40  
A1BLP C1    H11    sing N N 41  
A1BLP C1    H12    sing N N 42  
A1BLP O1    H13    sing N N 43  
A1BLP C2    H14    sing N N 44  
A1BLP C2    H15    sing N N 45  
A1BLP N2    H16    sing N N 46  
A1BLP C3    H17    sing N N 47  
A1BLP C3    H18    sing N N 48  
A1BLP C11   H19    sing N N 49  
A1BLP C11   H20    sing N N 50  
A1BLP C12   H21    sing N N 51  
A1BLP C12   H22    sing N N 52  
A1BLP C16   H23    sing N N 53  
A1BLP C18   H24    sing N N 54  
ALA   N     CA     sing N N 55  
ALA   N     H      sing N N 56  
ALA   N     H2     sing N N 57  
ALA   CA    C      sing N N 58  
ALA   CA    CB     sing N N 59  
ALA   CA    HA     sing N N 60  
ALA   C     O      doub N N 61  
ALA   C     OXT    sing N N 62  
ALA   CB    HB1    sing N N 63  
ALA   CB    HB2    sing N N 64  
ALA   CB    HB3    sing N N 65  
ALA   OXT   HXT    sing N N 66  
ARG   N     CA     sing N N 67  
ARG   N     H      sing N N 68  
ARG   N     H2     sing N N 69  
ARG   CA    C      sing N N 70  
ARG   CA    CB     sing N N 71  
ARG   CA    HA     sing N N 72  
ARG   C     O      doub N N 73  
ARG   C     OXT    sing N N 74  
ARG   CB    CG     sing N N 75  
ARG   CB    HB2    sing N N 76  
ARG   CB    HB3    sing N N 77  
ARG   CG    CD     sing N N 78  
ARG   CG    HG2    sing N N 79  
ARG   CG    HG3    sing N N 80  
ARG   CD    NE     sing N N 81  
ARG   CD    HD2    sing N N 82  
ARG   CD    HD3    sing N N 83  
ARG   NE    CZ     sing N N 84  
ARG   NE    HE     sing N N 85  
ARG   CZ    NH1    sing N N 86  
ARG   CZ    NH2    doub N N 87  
ARG   NH1   HH11   sing N N 88  
ARG   NH1   HH12   sing N N 89  
ARG   NH2   HH21   sing N N 90  
ARG   NH2   HH22   sing N N 91  
ARG   OXT   HXT    sing N N 92  
ASN   N     CA     sing N N 93  
ASN   N     H      sing N N 94  
ASN   N     H2     sing N N 95  
ASN   CA    C      sing N N 96  
ASN   CA    CB     sing N N 97  
ASN   CA    HA     sing N N 98  
ASN   C     O      doub N N 99  
ASN   C     OXT    sing N N 100 
ASN   CB    CG     sing N N 101 
ASN   CB    HB2    sing N N 102 
ASN   CB    HB3    sing N N 103 
ASN   CG    OD1    doub N N 104 
ASN   CG    ND2    sing N N 105 
ASN   ND2   HD21   sing N N 106 
ASN   ND2   HD22   sing N N 107 
ASN   OXT   HXT    sing N N 108 
ASP   N     CA     sing N N 109 
ASP   N     H      sing N N 110 
ASP   N     H2     sing N N 111 
ASP   CA    C      sing N N 112 
ASP   CA    CB     sing N N 113 
ASP   CA    HA     sing N N 114 
ASP   C     O      doub N N 115 
ASP   C     OXT    sing N N 116 
ASP   CB    CG     sing N N 117 
ASP   CB    HB2    sing N N 118 
ASP   CB    HB3    sing N N 119 
ASP   CG    OD1    doub N N 120 
ASP   CG    OD2    sing N N 121 
ASP   OD2   HD2    sing N N 122 
ASP   OXT   HXT    sing N N 123 
ATP   PG    O1G    doub N N 124 
ATP   PG    O2G    sing N N 125 
ATP   PG    O3G    sing N N 126 
ATP   PG    O3B    sing N N 127 
ATP   O2G   HOG2   sing N N 128 
ATP   O3G   HOG3   sing N N 129 
ATP   PB    O1B    doub N N 130 
ATP   PB    O2B    sing N N 131 
ATP   PB    O3B    sing N N 132 
ATP   PB    O3A    sing N N 133 
ATP   O2B   HOB2   sing N N 134 
ATP   PA    O1A    doub N N 135 
ATP   PA    O2A    sing N N 136 
ATP   PA    O3A    sing N N 137 
ATP   PA    "O5'"  sing N N 138 
ATP   O2A   HOA2   sing N N 139 
ATP   "O5'" "C5'"  sing N N 140 
ATP   "C5'" "C4'"  sing N N 141 
ATP   "C5'" "H5'1" sing N N 142 
ATP   "C5'" "H5'2" sing N N 143 
ATP   "C4'" "O4'"  sing N N 144 
ATP   "C4'" "C3'"  sing N N 145 
ATP   "C4'" "H4'"  sing N N 146 
ATP   "O4'" "C1'"  sing N N 147 
ATP   "C3'" "O3'"  sing N N 148 
ATP   "C3'" "C2'"  sing N N 149 
ATP   "C3'" "H3'"  sing N N 150 
ATP   "O3'" "HO3'" sing N N 151 
ATP   "C2'" "O2'"  sing N N 152 
ATP   "C2'" "C1'"  sing N N 153 
ATP   "C2'" "H2'"  sing N N 154 
ATP   "O2'" "HO2'" sing N N 155 
ATP   "C1'" N9     sing N N 156 
ATP   "C1'" "H1'"  sing N N 157 
ATP   N9    C8     sing Y N 158 
ATP   N9    C4     sing Y N 159 
ATP   C8    N7     doub Y N 160 
ATP   C8    H8     sing N N 161 
ATP   N7    C5     sing Y N 162 
ATP   C5    C6     sing Y N 163 
ATP   C5    C4     doub Y N 164 
ATP   C6    N6     sing N N 165 
ATP   C6    N1     doub Y N 166 
ATP   N6    HN61   sing N N 167 
ATP   N6    HN62   sing N N 168 
ATP   N1    C2     sing Y N 169 
ATP   C2    N3     doub Y N 170 
ATP   C2    H2     sing N N 171 
ATP   N3    C4     sing Y N 172 
CYS   N     CA     sing N N 173 
CYS   N     H      sing N N 174 
CYS   N     H2     sing N N 175 
CYS   CA    C      sing N N 176 
CYS   CA    CB     sing N N 177 
CYS   CA    HA     sing N N 178 
CYS   C     O      doub N N 179 
CYS   C     OXT    sing N N 180 
CYS   CB    SG     sing N N 181 
CYS   CB    HB2    sing N N 182 
CYS   CB    HB3    sing N N 183 
CYS   SG    HG     sing N N 184 
CYS   OXT   HXT    sing N N 185 
GLN   N     CA     sing N N 186 
GLN   N     H      sing N N 187 
GLN   N     H2     sing N N 188 
GLN   CA    C      sing N N 189 
GLN   CA    CB     sing N N 190 
GLN   CA    HA     sing N N 191 
GLN   C     O      doub N N 192 
GLN   C     OXT    sing N N 193 
GLN   CB    CG     sing N N 194 
GLN   CB    HB2    sing N N 195 
GLN   CB    HB3    sing N N 196 
GLN   CG    CD     sing N N 197 
GLN   CG    HG2    sing N N 198 
GLN   CG    HG3    sing N N 199 
GLN   CD    OE1    doub N N 200 
GLN   CD    NE2    sing N N 201 
GLN   NE2   HE21   sing N N 202 
GLN   NE2   HE22   sing N N 203 
GLN   OXT   HXT    sing N N 204 
GLU   N     CA     sing N N 205 
GLU   N     H      sing N N 206 
GLU   N     H2     sing N N 207 
GLU   CA    C      sing N N 208 
GLU   CA    CB     sing N N 209 
GLU   CA    HA     sing N N 210 
GLU   C     O      doub N N 211 
GLU   C     OXT    sing N N 212 
GLU   CB    CG     sing N N 213 
GLU   CB    HB2    sing N N 214 
GLU   CB    HB3    sing N N 215 
GLU   CG    CD     sing N N 216 
GLU   CG    HG2    sing N N 217 
GLU   CG    HG3    sing N N 218 
GLU   CD    OE1    doub N N 219 
GLU   CD    OE2    sing N N 220 
GLU   OE2   HE2    sing N N 221 
GLU   OXT   HXT    sing N N 222 
GLY   N     CA     sing N N 223 
GLY   N     H      sing N N 224 
GLY   N     H2     sing N N 225 
GLY   CA    C      sing N N 226 
GLY   CA    HA2    sing N N 227 
GLY   CA    HA3    sing N N 228 
GLY   C     O      doub N N 229 
GLY   C     OXT    sing N N 230 
GLY   OXT   HXT    sing N N 231 
HIS   N     CA     sing N N 232 
HIS   N     H      sing N N 233 
HIS   N     H2     sing N N 234 
HIS   CA    C      sing N N 235 
HIS   CA    CB     sing N N 236 
HIS   CA    HA     sing N N 237 
HIS   C     O      doub N N 238 
HIS   C     OXT    sing N N 239 
HIS   CB    CG     sing N N 240 
HIS   CB    HB2    sing N N 241 
HIS   CB    HB3    sing N N 242 
HIS   CG    ND1    sing Y N 243 
HIS   CG    CD2    doub Y N 244 
HIS   ND1   CE1    doub Y N 245 
HIS   ND1   HD1    sing N N 246 
HIS   CD2   NE2    sing Y N 247 
HIS   CD2   HD2    sing N N 248 
HIS   CE1   NE2    sing Y N 249 
HIS   CE1   HE1    sing N N 250 
HIS   NE2   HE2    sing N N 251 
HIS   OXT   HXT    sing N N 252 
ILE   N     CA     sing N N 253 
ILE   N     H      sing N N 254 
ILE   N     H2     sing N N 255 
ILE   CA    C      sing N N 256 
ILE   CA    CB     sing N N 257 
ILE   CA    HA     sing N N 258 
ILE   C     O      doub N N 259 
ILE   C     OXT    sing N N 260 
ILE   CB    CG1    sing N N 261 
ILE   CB    CG2    sing N N 262 
ILE   CB    HB     sing N N 263 
ILE   CG1   CD1    sing N N 264 
ILE   CG1   HG12   sing N N 265 
ILE   CG1   HG13   sing N N 266 
ILE   CG2   HG21   sing N N 267 
ILE   CG2   HG22   sing N N 268 
ILE   CG2   HG23   sing N N 269 
ILE   CD1   HD11   sing N N 270 
ILE   CD1   HD12   sing N N 271 
ILE   CD1   HD13   sing N N 272 
ILE   OXT   HXT    sing N N 273 
LEU   N     CA     sing N N 274 
LEU   N     H      sing N N 275 
LEU   N     H2     sing N N 276 
LEU   CA    C      sing N N 277 
LEU   CA    CB     sing N N 278 
LEU   CA    HA     sing N N 279 
LEU   C     O      doub N N 280 
LEU   C     OXT    sing N N 281 
LEU   CB    CG     sing N N 282 
LEU   CB    HB2    sing N N 283 
LEU   CB    HB3    sing N N 284 
LEU   CG    CD1    sing N N 285 
LEU   CG    CD2    sing N N 286 
LEU   CG    HG     sing N N 287 
LEU   CD1   HD11   sing N N 288 
LEU   CD1   HD12   sing N N 289 
LEU   CD1   HD13   sing N N 290 
LEU   CD2   HD21   sing N N 291 
LEU   CD2   HD22   sing N N 292 
LEU   CD2   HD23   sing N N 293 
LEU   OXT   HXT    sing N N 294 
LYS   N     CA     sing N N 295 
LYS   N     H      sing N N 296 
LYS   N     H2     sing N N 297 
LYS   CA    C      sing N N 298 
LYS   CA    CB     sing N N 299 
LYS   CA    HA     sing N N 300 
LYS   C     O      doub N N 301 
LYS   C     OXT    sing N N 302 
LYS   CB    CG     sing N N 303 
LYS   CB    HB2    sing N N 304 
LYS   CB    HB3    sing N N 305 
LYS   CG    CD     sing N N 306 
LYS   CG    HG2    sing N N 307 
LYS   CG    HG3    sing N N 308 
LYS   CD    CE     sing N N 309 
LYS   CD    HD2    sing N N 310 
LYS   CD    HD3    sing N N 311 
LYS   CE    NZ     sing N N 312 
LYS   CE    HE2    sing N N 313 
LYS   CE    HE3    sing N N 314 
LYS   NZ    HZ1    sing N N 315 
LYS   NZ    HZ2    sing N N 316 
LYS   NZ    HZ3    sing N N 317 
LYS   OXT   HXT    sing N N 318 
MET   N     CA     sing N N 319 
MET   N     H      sing N N 320 
MET   N     H2     sing N N 321 
MET   CA    C      sing N N 322 
MET   CA    CB     sing N N 323 
MET   CA    HA     sing N N 324 
MET   C     O      doub N N 325 
MET   C     OXT    sing N N 326 
MET   CB    CG     sing N N 327 
MET   CB    HB2    sing N N 328 
MET   CB    HB3    sing N N 329 
MET   CG    SD     sing N N 330 
MET   CG    HG2    sing N N 331 
MET   CG    HG3    sing N N 332 
MET   SD    CE     sing N N 333 
MET   CE    HE1    sing N N 334 
MET   CE    HE2    sing N N 335 
MET   CE    HE3    sing N N 336 
MET   OXT   HXT    sing N N 337 
PHE   N     CA     sing N N 338 
PHE   N     H      sing N N 339 
PHE   N     H2     sing N N 340 
PHE   CA    C      sing N N 341 
PHE   CA    CB     sing N N 342 
PHE   CA    HA     sing N N 343 
PHE   C     O      doub N N 344 
PHE   C     OXT    sing N N 345 
PHE   CB    CG     sing N N 346 
PHE   CB    HB2    sing N N 347 
PHE   CB    HB3    sing N N 348 
PHE   CG    CD1    doub Y N 349 
PHE   CG    CD2    sing Y N 350 
PHE   CD1   CE1    sing Y N 351 
PHE   CD1   HD1    sing N N 352 
PHE   CD2   CE2    doub Y N 353 
PHE   CD2   HD2    sing N N 354 
PHE   CE1   CZ     doub Y N 355 
PHE   CE1   HE1    sing N N 356 
PHE   CE2   CZ     sing Y N 357 
PHE   CE2   HE2    sing N N 358 
PHE   CZ    HZ     sing N N 359 
PHE   OXT   HXT    sing N N 360 
PRO   N     CA     sing N N 361 
PRO   N     CD     sing N N 362 
PRO   N     H      sing N N 363 
PRO   CA    C      sing N N 364 
PRO   CA    CB     sing N N 365 
PRO   CA    HA     sing N N 366 
PRO   C     O      doub N N 367 
PRO   C     OXT    sing N N 368 
PRO   CB    CG     sing N N 369 
PRO   CB    HB2    sing N N 370 
PRO   CB    HB3    sing N N 371 
PRO   CG    CD     sing N N 372 
PRO   CG    HG2    sing N N 373 
PRO   CG    HG3    sing N N 374 
PRO   CD    HD2    sing N N 375 
PRO   CD    HD3    sing N N 376 
PRO   OXT   HXT    sing N N 377 
SER   N     CA     sing N N 378 
SER   N     H      sing N N 379 
SER   N     H2     sing N N 380 
SER   CA    C      sing N N 381 
SER   CA    CB     sing N N 382 
SER   CA    HA     sing N N 383 
SER   C     O      doub N N 384 
SER   C     OXT    sing N N 385 
SER   CB    OG     sing N N 386 
SER   CB    HB2    sing N N 387 
SER   CB    HB3    sing N N 388 
SER   OG    HG     sing N N 389 
SER   OXT   HXT    sing N N 390 
THR   N     CA     sing N N 391 
THR   N     H      sing N N 392 
THR   N     H2     sing N N 393 
THR   CA    C      sing N N 394 
THR   CA    CB     sing N N 395 
THR   CA    HA     sing N N 396 
THR   C     O      doub N N 397 
THR   C     OXT    sing N N 398 
THR   CB    OG1    sing N N 399 
THR   CB    CG2    sing N N 400 
THR   CB    HB     sing N N 401 
THR   OG1   HG1    sing N N 402 
THR   CG2   HG21   sing N N 403 
THR   CG2   HG22   sing N N 404 
THR   CG2   HG23   sing N N 405 
THR   OXT   HXT    sing N N 406 
TRP   N     CA     sing N N 407 
TRP   N     H      sing N N 408 
TRP   N     H2     sing N N 409 
TRP   CA    C      sing N N 410 
TRP   CA    CB     sing N N 411 
TRP   CA    HA     sing N N 412 
TRP   C     O      doub N N 413 
TRP   C     OXT    sing N N 414 
TRP   CB    CG     sing N N 415 
TRP   CB    HB2    sing N N 416 
TRP   CB    HB3    sing N N 417 
TRP   CG    CD1    doub Y N 418 
TRP   CG    CD2    sing Y N 419 
TRP   CD1   NE1    sing Y N 420 
TRP   CD1   HD1    sing N N 421 
TRP   CD2   CE2    doub Y N 422 
TRP   CD2   CE3    sing Y N 423 
TRP   NE1   CE2    sing Y N 424 
TRP   NE1   HE1    sing N N 425 
TRP   CE2   CZ2    sing Y N 426 
TRP   CE3   CZ3    doub Y N 427 
TRP   CE3   HE3    sing N N 428 
TRP   CZ2   CH2    doub Y N 429 
TRP   CZ2   HZ2    sing N N 430 
TRP   CZ3   CH2    sing Y N 431 
TRP   CZ3   HZ3    sing N N 432 
TRP   CH2   HH2    sing N N 433 
TRP   OXT   HXT    sing N N 434 
TYR   N     CA     sing N N 435 
TYR   N     H      sing N N 436 
TYR   N     H2     sing N N 437 
TYR   CA    C      sing N N 438 
TYR   CA    CB     sing N N 439 
TYR   CA    HA     sing N N 440 
TYR   C     O      doub N N 441 
TYR   C     OXT    sing N N 442 
TYR   CB    CG     sing N N 443 
TYR   CB    HB2    sing N N 444 
TYR   CB    HB3    sing N N 445 
TYR   CG    CD1    doub Y N 446 
TYR   CG    CD2    sing Y N 447 
TYR   CD1   CE1    sing Y N 448 
TYR   CD1   HD1    sing N N 449 
TYR   CD2   CE2    doub Y N 450 
TYR   CD2   HD2    sing N N 451 
TYR   CE1   CZ     doub Y N 452 
TYR   CE1   HE1    sing N N 453 
TYR   CE2   CZ     sing Y N 454 
TYR   CE2   HE2    sing N N 455 
TYR   CZ    OH     sing N N 456 
TYR   OH    HH     sing N N 457 
TYR   OXT   HXT    sing N N 458 
VAL   N     CA     sing N N 459 
VAL   N     H      sing N N 460 
VAL   N     H2     sing N N 461 
VAL   CA    C      sing N N 462 
VAL   CA    CB     sing N N 463 
VAL   CA    HA     sing N N 464 
VAL   C     O      doub N N 465 
VAL   C     OXT    sing N N 466 
VAL   CB    CG1    sing N N 467 
VAL   CB    CG2    sing N N 468 
VAL   CB    HB     sing N N 469 
VAL   CG1   HG11   sing N N 470 
VAL   CG1   HG12   sing N N 471 
VAL   CG1   HG13   sing N N 472 
VAL   CG2   HG21   sing N N 473 
VAL   CG2   HG22   sing N N 474 
VAL   CG2   HG23   sing N N 475 
VAL   OXT   HXT    sing N N 476 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-12-12 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9MIE 
_em_admin.last_update        2025-03-12 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Human NLRP3 complex with compound 2 in the closed hexamer' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         52.34 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9MIE 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
F 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . LYS   A 1 133  ? 158.012 157.797 165.838 1.00 65.64  ?  133  LYS   C N     1 
ATOM   2    C CA    . LYS   A 1 133  ? 157.834 158.212 164.445 1.00 66.25  ?  133  LYS   C CA    1 
ATOM   3    C C     . LYS   A 1 133  ? 158.467 157.230 163.441 1.00 66.41  ?  133  LYS   C C     1 
ATOM   4    O O     . LYS   A 1 133  ? 158.177 157.301 162.242 1.00 65.74  ?  133  LYS   C O     1 
ATOM   5    C CB    . LYS   A 1 133  ? 158.409 159.626 164.220 1.00 76.87  ?  133  LYS   C CB    1 
ATOM   6    C CG    . LYS   A 1 133  ? 157.652 160.775 164.960 1.00 88.49  ?  133  LYS   C CG    1 
ATOM   7    C CD    . LYS   A 1 133  ? 158.275 162.174 164.646 1.00 93.42  ?  133  LYS   C CD    1 
ATOM   8    C CE    . LYS   A 1 133  ? 157.515 163.328 165.354 1.00 97.44  ?  133  LYS   C CE    1 
ATOM   9    N NZ    . LYS   A 1 133  ? 158.133 164.665 165.075 1.00 99.27  1  133  LYS   C NZ    1 
ATOM   10   N N     . LYS   A 1 134  ? 159.331 156.325 163.927 1.00 70.18  ?  134  LYS   C N     1 
ATOM   11   C CA    . LYS   A 1 134  ? 160.013 155.331 163.096 1.00 68.28  ?  134  LYS   C CA    1 
ATOM   12   C C     . LYS   A 1 134  ? 159.420 153.945 163.300 1.00 58.75  ?  134  LYS   C C     1 
ATOM   13   O O     . LYS   A 1 134  ? 158.902 153.625 164.371 1.00 52.43  ?  134  LYS   C O     1 
ATOM   14   C CB    . LYS   A 1 134  ? 161.512 155.314 163.398 1.00 61.91  ?  134  LYS   C CB    1 
ATOM   15   C CG    . LYS   A 1 134  ? 162.223 156.653 163.191 1.00 60.04  ?  134  LYS   C CG    1 
ATOM   16   C CD    . LYS   A 1 134  ? 162.164 157.103 161.732 1.00 63.22  ?  134  LYS   C CD    1 
ATOM   17   C CE    . LYS   A 1 134  ? 162.985 158.361 161.506 1.00 71.75  ?  134  LYS   C CE    1 
ATOM   18   N NZ    . LYS   A 1 134  ? 162.893 158.833 160.103 1.00 65.95  1  134  LYS   C NZ    1 
ATOM   19   N N     . ASP   A 1 135  ? 159.511 153.122 162.264 1.00 55.58  ?  135  ASP   C N     1 
ATOM   20   C CA    . ASP   A 1 135  ? 159.005 151.760 162.313 1.00 51.46  ?  135  ASP   C CA    1 
ATOM   21   C C     . ASP   A 1 135  ? 160.042 150.819 162.907 1.00 46.13  ?  135  ASP   C C     1 
ATOM   22   O O     . ASP   A 1 135  ? 161.081 150.555 162.298 1.00 44.40  ?  135  ASP   C O     1 
ATOM   23   C CB    . ASP   A 1 135  ? 158.589 151.292 160.918 1.00 59.28  ?  135  ASP   C CB    1 
ATOM   24   C CG    . ASP   A 1 135  ? 157.906 149.920 160.910 1.00 54.69  ?  135  ASP   C CG    1 
ATOM   25   O OD1   . ASP   A 1 135  ? 158.094 149.150 161.823 1.00 48.57  ?  135  ASP   C OD1   1 
ATOM   26   O OD2   . ASP   A 1 135  ? 157.188 149.657 159.981 1.00 50.01  -1 135  ASP   C OD2   1 
ATOM   27   N N     . TYR   A 1 136  ? 159.758 150.337 164.111 1.00 42.91  ?  136  TYR   C N     1 
ATOM   28   C CA    . TYR   A 1 136  ? 160.670 149.505 164.889 1.00 39.04  ?  136  TYR   C CA    1 
ATOM   29   C C     . TYR   A 1 136  ? 161.137 148.277 164.130 1.00 37.27  ?  136  TYR   C C     1 
ATOM   30   O O     . TYR   A 1 136  ? 162.202 147.730 164.423 1.00 37.04  ?  136  TYR   C O     1 
ATOM   31   C CB    . TYR   A 1 136  ? 160.002 149.078 166.192 1.00 36.85  ?  136  TYR   C CB    1 
ATOM   32   C CG    . TYR   A 1 136  ? 160.869 148.246 167.088 1.00 33.51  ?  136  TYR   C CG    1 
ATOM   33   C CD1   . TYR   A 1 136  ? 161.899 148.830 167.801 1.00 38.38  ?  136  TYR   C CD1   1 
ATOM   34   C CD2   . TYR   A 1 136  ? 160.626 146.895 167.204 1.00 34.11  ?  136  TYR   C CD2   1 
ATOM   35   C CE1   . TYR   A 1 136  ? 162.679 148.059 168.631 1.00 40.42  ?  136  TYR   C CE1   1 
ATOM   36   C CE2   . TYR   A 1 136  ? 161.405 146.125 168.028 1.00 36.20  ?  136  TYR   C CE2   1 
ATOM   37   C CZ    . TYR   A 1 136  ? 162.428 146.699 168.740 1.00 38.64  ?  136  TYR   C CZ    1 
ATOM   38   O OH    . TYR   A 1 136  ? 163.197 145.919 169.566 1.00 39.85  ?  136  TYR   C OH    1 
ATOM   39   N N     . ARG   A 1 137  ? 160.332 147.820 163.178 1.00 37.62  ?  137  ARG   C N     1 
ATOM   40   C CA    . ARG   A 1 137  ? 160.664 146.610 162.446 1.00 36.35  ?  137  ARG   C CA    1 
ATOM   41   C C     . ARG   A 1 137  ? 161.988 146.755 161.710 1.00 35.86  ?  137  ARG   C C     1 
ATOM   42   O O     . ARG   A 1 137  ? 162.713 145.776 161.528 1.00 36.22  ?  137  ARG   C O     1 
ATOM   43   C CB    . ARG   A 1 137  ? 159.573 146.262 161.447 1.00 36.12  ?  137  ARG   C CB    1 
ATOM   44   C CG    . ARG   A 1 137  ? 158.278 145.780 162.060 1.00 35.88  ?  137  ARG   C CG    1 
ATOM   45   C CD    . ARG   A 1 137  ? 157.274 145.422 161.031 1.00 42.26  ?  137  ARG   C CD    1 
ATOM   46   N NE    . ARG   A 1 137  ? 156.804 146.592 160.314 1.00 47.50  ?  137  ARG   C NE    1 
ATOM   47   C CZ    . ARG   A 1 137  ? 155.954 146.586 159.265 1.00 54.60  ?  137  ARG   C CZ    1 
ATOM   48   N NH1   . ARG   A 1 137  ? 155.447 145.465 158.787 1.00 43.70  1  137  ARG   C NH1   1 
ATOM   49   N NH2   . ARG   A 1 137  ? 155.629 147.735 158.715 1.00 60.22  ?  137  ARG   C NH2   1 
ATOM   50   N N     . LYS   A 1 138  ? 162.305 147.969 161.267 1.00 37.10  ?  138  LYS   C N     1 
ATOM   51   C CA    . LYS   A 1 138  ? 163.531 148.172 160.510 1.00 37.36  ?  138  LYS   C CA    1 
ATOM   52   C C     . LYS   A 1 138  ? 164.746 147.970 161.395 1.00 34.29  ?  138  LYS   C C     1 
ATOM   53   O O     . LYS   A 1 138  ? 165.703 147.293 161.011 1.00 35.65  ?  138  LYS   C O     1 
ATOM   54   C CB    . LYS   A 1 138  ? 163.552 149.568 159.893 1.00 46.41  ?  138  LYS   C CB    1 
ATOM   55   C CG    . LYS   A 1 138  ? 164.772 149.858 159.028 1.00 47.11  ?  138  LYS   C CG    1 
ATOM   56   C CD    . LYS   A 1 138  ? 164.661 151.224 158.370 1.00 46.67  ?  138  LYS   C CD    1 
ATOM   57   C CE    . LYS   A 1 138  ? 165.874 151.527 157.511 1.00 44.97  ?  138  LYS   C CE    1 
ATOM   58   N NZ    . LYS   A 1 138  ? 165.767 152.856 156.861 1.00 45.84  1  138  LYS   C NZ    1 
ATOM   59   N N     . LYS   A 1 139  ? 164.703 148.548 162.587 1.00 33.64  ?  139  LYS   C N     1 
ATOM   60   C CA    . LYS   A 1 139  ? 165.802 148.411 163.523 1.00 34.02  ?  139  LYS   C CA    1 
ATOM   61   C C     . LYS   A 1 139  ? 165.908 146.982 164.017 1.00 35.36  ?  139  LYS   C C     1 
ATOM   62   O O     . LYS   A 1 139  ? 167.010 146.468 164.216 1.00 37.66  ?  139  LYS   C O     1 
ATOM   63   C CB    . LYS   A 1 139  ? 165.632 149.367 164.700 1.00 38.77  ?  139  LYS   C CB    1 
ATOM   64   C CG    . LYS   A 1 139  ? 165.850 150.827 164.344 1.00 45.72  ?  139  LYS   C CG    1 
ATOM   65   C CD    . LYS   A 1 139  ? 165.676 151.730 165.555 1.00 62.97  ?  139  LYS   C CD    1 
ATOM   66   C CE    . LYS   A 1 139  ? 165.932 153.189 165.198 1.00 68.68  ?  139  LYS   C CE    1 
ATOM   67   N NZ    . LYS   A 1 139  ? 165.751 154.090 166.370 1.00 73.27  1  139  LYS   C NZ    1 
ATOM   68   N N     . TYR   A 1 140  ? 164.763 146.336 164.216 1.00 33.19  ?  140  TYR   C N     1 
ATOM   69   C CA    . TYR   A 1 140  ? 164.767 144.965 164.690 1.00 29.50  ?  140  TYR   C CA    1 
ATOM   70   C C     . TYR   A 1 140  ? 165.495 144.083 163.696 1.00 28.25  ?  140  TYR   C C     1 
ATOM   71   O O     . TYR   A 1 140  ? 166.349 143.280 164.073 1.00 31.09  ?  140  TYR   C O     1 
ATOM   72   C CB    . TYR   A 1 140  ? 163.349 144.447 164.903 1.00 30.29  ?  140  TYR   C CB    1 
ATOM   73   C CG    . TYR   A 1 140  ? 163.309 143.087 165.546 1.00 22.60  ?  140  TYR   C CG    1 
ATOM   74   C CD1   . TYR   A 1 140  ? 163.341 142.984 166.921 1.00 27.54  ?  140  TYR   C CD1   1 
ATOM   75   C CD2   . TYR   A 1 140  ? 163.258 141.949 164.775 1.00 23.18  ?  140  TYR   C CD2   1 
ATOM   76   C CE1   . TYR   A 1 140  ? 163.313 141.751 167.518 1.00 28.42  ?  140  TYR   C CE1   1 
ATOM   77   C CE2   . TYR   A 1 140  ? 163.230 140.710 165.379 1.00 23.22  ?  140  TYR   C CE2   1 
ATOM   78   C CZ    . TYR   A 1 140  ? 163.262 140.618 166.749 1.00 24.87  ?  140  TYR   C CZ    1 
ATOM   79   O OH    . TYR   A 1 140  ? 163.242 139.398 167.369 1.00 29.45  ?  140  TYR   C OH    1 
ATOM   80   N N     . ARG   A 1 141  ? 165.162 144.238 162.417 1.00 27.65  ?  141  ARG   C N     1 
ATOM   81   C CA    . ARG   A 1 141  ? 165.795 143.441 161.380 1.00 27.51  ?  141  ARG   C CA    1 
ATOM   82   C C     . ARG   A 1 141  ? 167.292 143.694 161.313 1.00 27.57  ?  141  ARG   C C     1 
ATOM   83   O O     . ARG   A 1 141  ? 168.071 142.752 161.177 1.00 30.93  ?  141  ARG   C O     1 
ATOM   84   C CB    . ARG   A 1 141  ? 165.168 143.730 160.031 1.00 27.02  ?  141  ARG   C CB    1 
ATOM   85   C CG    . ARG   A 1 141  ? 163.790 143.143 159.840 1.00 26.03  ?  141  ARG   C CG    1 
ATOM   86   C CD    . ARG   A 1 141  ? 163.181 143.594 158.579 1.00 27.73  ?  141  ARG   C CD    1 
ATOM   87   N NE    . ARG   A 1 141  ? 161.843 143.074 158.415 1.00 28.24  ?  141  ARG   C NE    1 
ATOM   88   C CZ    . ARG   A 1 141  ? 161.538 141.885 157.860 1.00 32.65  ?  141  ARG   C CZ    1 
ATOM   89   N NH1   . ARG   A 1 141  ? 162.486 141.093 157.409 1.00 36.19  1  141  ARG   C NH1   1 
ATOM   90   N NH2   . ARG   A 1 141  ? 160.277 141.513 157.765 1.00 32.71  ?  141  ARG   C NH2   1 
ATOM   91   N N     . LYS   A 1 142  ? 167.706 144.954 161.431 1.00 28.06  ?  142  LYS   C N     1 
ATOM   92   C CA    . LYS   A 1 142  ? 169.130 145.254 161.404 1.00 27.84  ?  142  LYS   C CA    1 
ATOM   93   C C     . LYS   A 1 142  ? 169.848 144.552 162.541 1.00 28.91  ?  142  LYS   C C     1 
ATOM   94   O O     . LYS   A 1 142  ? 170.907 143.959 162.338 1.00 34.38  ?  142  LYS   C O     1 
ATOM   95   C CB    . LYS   A 1 142  ? 169.386 146.756 161.486 1.00 34.51  ?  142  LYS   C CB    1 
ATOM   96   C CG    . LYS   A 1 142  ? 170.870 147.132 161.444 1.00 35.14  ?  142  LYS   C CG    1 
ATOM   97   C CD    . LYS   A 1 142  ? 171.070 148.643 161.478 1.00 54.79  ?  142  LYS   C CD    1 
ATOM   98   C CE    . LYS   A 1 142  ? 172.553 149.006 161.499 1.00 78.75  ?  142  LYS   C CE    1 
ATOM   99   N NZ    . LYS   A 1 142  ? 172.768 150.485 161.542 1.00 85.84  1  142  LYS   C NZ    1 
ATOM   100  N N     . TYR   A 1 143  ? 169.274 144.615 163.737 1.00 28.36  ?  143  TYR   C N     1 
ATOM   101  C CA    . TYR   A 1 143  ? 169.883 143.975 164.891 1.00 29.74  ?  143  TYR   C CA    1 
ATOM   102  C C     . TYR   A 1 143  ? 170.062 142.490 164.666 1.00 31.83  ?  143  TYR   C C     1 
ATOM   103  O O     . TYR   A 1 143  ? 171.142 141.942 164.896 1.00 35.08  ?  143  TYR   C O     1 
ATOM   104  C CB    . TYR   A 1 143  ? 169.047 144.200 166.141 1.00 31.11  ?  143  TYR   C CB    1 
ATOM   105  C CG    . TYR   A 1 143  ? 169.586 143.474 167.329 1.00 33.79  ?  143  TYR   C CG    1 
ATOM   106  C CD1   . TYR   A 1 143  ? 170.708 143.955 167.967 1.00 41.29  ?  143  TYR   C CD1   1 
ATOM   107  C CD2   . TYR   A 1 143  ? 168.954 142.336 167.797 1.00 37.20  ?  143  TYR   C CD2   1 
ATOM   108  C CE1   . TYR   A 1 143  ? 171.206 143.302 169.068 1.00 47.12  ?  143  TYR   C CE1   1 
ATOM   109  C CE2   . TYR   A 1 143  ? 169.452 141.682 168.903 1.00 42.80  ?  143  TYR   C CE2   1 
ATOM   110  C CZ    . TYR   A 1 143  ? 170.574 142.169 169.541 1.00 46.84  ?  143  TYR   C CZ    1 
ATOM   111  O OH    . TYR   A 1 143  ? 171.072 141.535 170.655 1.00 49.89  ?  143  TYR   C OH    1 
ATOM   112  N N     . VAL   A 1 144  ? 169.007 141.835 164.212 1.00 29.55  ?  144  VAL   C N     1 
ATOM   113  C CA    . VAL   A 1 144  ? 169.059 140.408 163.973 1.00 25.07  ?  144  VAL   C CA    1 
ATOM   114  C C     . VAL   A 1 144  ? 170.077 140.078 162.897 1.00 26.28  ?  144  VAL   C C     1 
ATOM   115  O O     . VAL   A 1 144  ? 170.852 139.133 163.035 1.00 31.43  ?  144  VAL   C O     1 
ATOM   116  C CB    . VAL   A 1 144  ? 167.674 139.890 163.562 1.00 22.04  ?  144  VAL   C CB    1 
ATOM   117  C CG1   . VAL   A 1 144  ? 167.760 138.468 163.096 1.00 22.68  ?  144  VAL   C CG1   1 
ATOM   118  C CG2   . VAL   A 1 144  ? 166.737 139.983 164.745 1.00 26.39  ?  144  VAL   C CG2   1 
ATOM   119  N N     . ARG   A 1 145  ? 170.075 140.855 161.821 1.00 27.22  ?  145  ARG   C N     1 
ATOM   120  C CA    . ARG   A 1 145  ? 170.993 140.611 160.724 1.00 27.56  ?  145  ARG   C CA    1 
ATOM   121  C C     . ARG   A 1 145  ? 172.439 140.708 161.183 1.00 26.85  ?  145  ARG   C C     1 
ATOM   122  O O     . ARG   A 1 145  ? 173.274 139.914 160.759 1.00 32.55  ?  145  ARG   C O     1 
ATOM   123  C CB    . ARG   A 1 145  ? 170.750 141.597 159.594 1.00 30.81  ?  145  ARG   C CB    1 
ATOM   124  C CG    . ARG   A 1 145  ? 171.540 141.335 158.329 1.00 29.21  ?  145  ARG   C CG    1 
ATOM   125  C CD    . ARG   A 1 145  ? 171.138 142.259 157.247 1.00 31.79  ?  145  ARG   C CD    1 
ATOM   126  N NE    . ARG   A 1 145  ? 171.495 143.634 157.558 1.00 34.83  ?  145  ARG   C NE    1 
ATOM   127  C CZ    . ARG   A 1 145  ? 171.001 144.721 156.933 1.00 36.04  ?  145  ARG   C CZ    1 
ATOM   128  N NH1   . ARG   A 1 145  ? 170.126 144.586 155.960 1.00 33.89  1  145  ARG   C NH1   1 
ATOM   129  N NH2   . ARG   A 1 145  ? 171.401 145.925 157.299 1.00 36.77  ?  145  ARG   C NH2   1 
ATOM   130  N N     . SER   A 1 146  ? 172.736 141.670 162.053 1.00 27.69  ?  146  SER   C N     1 
ATOM   131  C CA    . SER   A 1 146  ? 174.088 141.839 162.571 1.00 29.30  ?  146  SER   C CA    1 
ATOM   132  C C     . SER   A 1 146  ? 174.457 140.778 163.600 1.00 31.12  ?  146  SER   C C     1 
ATOM   133  O O     . SER   A 1 146  ? 175.597 140.317 163.643 1.00 38.19  ?  146  SER   C O     1 
ATOM   134  C CB    . SER   A 1 146  ? 174.244 143.211 163.194 1.00 34.22  ?  146  SER   C CB    1 
ATOM   135  O OG    . SER   A 1 146  ? 174.176 144.220 162.223 1.00 39.27  ?  146  SER   C OG    1 
ATOM   136  N N     . ARG   A 1 147  ? 173.501 140.395 164.440 1.00 30.06  ?  147  ARG   C N     1 
ATOM   137  C CA    . ARG   A 1 147  ? 173.781 139.441 165.504 1.00 33.04  ?  147  ARG   C CA    1 
ATOM   138  C C     . ARG   A 1 147  ? 174.003 138.028 164.982 1.00 34.28  ?  147  ARG   C C     1 
ATOM   139  O O     . ARG   A 1 147  ? 174.948 137.349 165.379 1.00 40.35  ?  147  ARG   C O     1 
ATOM   140  C CB    . ARG   A 1 147  ? 172.641 139.411 166.508 1.00 42.76  ?  147  ARG   C CB    1 
ATOM   141  C CG    . ARG   A 1 147  ? 172.873 138.509 167.713 1.00 47.26  ?  147  ARG   C CG    1 
ATOM   142  C CD    . ARG   A 1 147  ? 171.723 138.537 168.644 1.00 51.66  ?  147  ARG   C CD    1 
ATOM   143  N NE    . ARG   A 1 147  ? 171.969 137.735 169.832 1.00 61.24  ?  147  ARG   C NE    1 
ATOM   144  C CZ    . ARG   A 1 147  ? 171.022 137.275 170.671 1.00 64.98  ?  147  ARG   C CZ    1 
ATOM   145  N NH1   . ARG   A 1 147  ? 169.747 137.526 170.453 1.00 54.77  1  147  ARG   C NH1   1 
ATOM   146  N NH2   . ARG   A 1 147  ? 171.391 136.567 171.722 1.00 67.91  ?  147  ARG   C NH2   1 
ATOM   147  N N     . PHE   A 1 148  ? 173.134 137.569 164.093 1.00 32.89  ?  148  PHE   C N     1 
ATOM   148  C CA    . PHE   A 1 148  ? 173.214 136.193 163.620 1.00 29.40  ?  148  PHE   C CA    1 
ATOM   149  C C     . PHE   A 1 148  ? 174.141 136.029 162.427 1.00 32.80  ?  148  PHE   C C     1 
ATOM   150  O O     . PHE   A 1 148  ? 173.730 135.574 161.360 1.00 30.00  ?  148  PHE   C O     1 
ATOM   151  C CB    . PHE   A 1 148  ? 171.822 135.677 163.275 1.00 25.58  ?  148  PHE   C CB    1 
ATOM   152  C CG    . PHE   A 1 148  ? 170.970 135.460 164.482 1.00 24.80  ?  148  PHE   C CG    1 
ATOM   153  C CD1   . PHE   A 1 148  ? 170.251 136.492 165.030 1.00 29.04  ?  148  PHE   C CD1   1 
ATOM   154  C CD2   . PHE   A 1 148  ? 170.887 134.214 165.068 1.00 30.59  ?  148  PHE   C CD2   1 
ATOM   155  C CE1   . PHE   A 1 148  ? 169.469 136.296 166.139 1.00 34.46  ?  148  PHE   C CE1   1 
ATOM   156  C CE2   . PHE   A 1 148  ? 170.105 134.009 166.180 1.00 33.81  ?  148  PHE   C CE2   1 
ATOM   157  C CZ    . PHE   A 1 148  ? 169.395 135.054 166.716 1.00 34.18  ?  148  PHE   C CZ    1 
ATOM   158  N N     . GLN   A 1 149  ? 175.411 136.348 162.637 1.00 37.09  ?  149  GLN   C N     1 
ATOM   159  C CA    . GLN   A 1 149  ? 176.438 136.134 161.628 1.00 39.08  ?  149  GLN   C CA    1 
ATOM   160  C C     . GLN   A 1 149  ? 177.581 135.318 162.196 1.00 50.29  ?  149  GLN   C C     1 
ATOM   161  O O     . GLN   A 1 149  ? 178.718 135.418 161.740 1.00 60.67  ?  149  GLN   C O     1 
ATOM   162  C CB    . GLN   A 1 149  ? 176.958 137.447 161.056 1.00 37.48  ?  149  GLN   C CB    1 
ATOM   163  C CG    . GLN   A 1 149  ? 175.927 138.202 160.275 1.00 36.52  ?  149  GLN   C CG    1 
ATOM   164  C CD    . GLN   A 1 149  ? 176.485 139.430 159.601 1.00 39.40  ?  149  GLN   C CD    1 
ATOM   165  O OE1   . GLN   A 1 149  ? 177.607 139.430 159.086 1.00 41.03  ?  149  GLN   C OE1   1 
ATOM   166  N NE2   . GLN   A 1 149  ? 175.700 140.489 159.598 1.00 40.53  ?  149  GLN   C NE2   1 
ATOM   167  N N     . CYS   A 1 150  ? 177.266 134.497 163.186 1.00 54.50  ?  150  CYS   C N     1 
ATOM   168  C CA    . CYS   A 1 150  ? 178.245 133.616 163.797 1.00 63.45  ?  150  CYS   C CA    1 
ATOM   169  C C     . CYS   A 1 150  ? 177.634 132.246 164.030 1.00 66.17  ?  150  CYS   C C     1 
ATOM   170  O O     . CYS   A 1 150  ? 176.460 132.131 164.377 1.00 61.65  ?  150  CYS   C O     1 
ATOM   171  C CB    . CYS   A 1 150  ? 178.757 134.188 165.116 1.00 73.26  ?  150  CYS   C CB    1 
ATOM   172  S SG    . CYS   A 1 150  ? 180.111 133.226 165.849 1.00 94.45  ?  150  CYS   C SG    1 
ATOM   173  N N     . ILE   A 1 151  ? 178.430 131.209 163.810 1.00 69.91  ?  151  ILE   C N     1 
ATOM   174  C CA    . ILE   A 1 151  ? 177.959 129.837 163.907 1.00 68.58  ?  151  ILE   C CA    1 
ATOM   175  C C     . ILE   A 1 151  ? 177.551 129.471 165.337 1.00 71.08  ?  151  ILE   C C     1 
ATOM   176  O O     . ILE   A 1 151  ? 176.510 128.849 165.544 1.00 66.27  ?  151  ILE   C O     1 
ATOM   177  C CB    . ILE   A 1 151  ? 179.064 128.880 163.405 1.00 62.32  ?  151  ILE   C CB    1 
ATOM   178  C CG1   . ILE   A 1 151  ? 179.416 129.192 161.923 1.00 60.74  ?  151  ILE   C CG1   1 
ATOM   179  C CG2   . ILE   A 1 151  ? 178.644 127.431 163.545 1.00 66.46  ?  151  ILE   C CG2   1 
ATOM   180  C CD1   . ILE   A 1 151  ? 178.263 129.043 160.930 1.00 58.16  ?  151  ILE   C CD1   1 
ATOM   181  N N     . GLU   A 1 152  ? 178.371 129.848 166.320 1.00 77.27  ?  152  GLU   C N     1 
ATOM   182  C CA    . GLU   A 1 152  ? 178.072 129.524 167.716 1.00 77.25  ?  152  GLU   C CA    1 
ATOM   183  C C     . GLU   A 1 152  ? 178.039 130.749 168.631 1.00 86.45  ?  152  GLU   C C     1 
ATOM   184  O O     . GLU   A 1 152  ? 177.993 130.606 169.851 1.00 87.98  ?  152  GLU   C O     1 
ATOM   185  C CB    . GLU   A 1 152  ? 179.096 128.530 168.270 1.00 84.36  ?  152  GLU   C CB    1 
ATOM   186  C CG    . GLU   A 1 152  ? 179.176 127.191 167.547 1.00 81.24  ?  152  GLU   C CG    1 
ATOM   187  C CD    . GLU   A 1 152  ? 177.915 126.373 167.662 1.00 77.32  ?  152  GLU   C CD    1 
ATOM   188  O OE1   . GLU   A 1 152  ? 177.134 126.647 168.543 1.00 67.70  ?  152  GLU   C OE1   1 
ATOM   189  O OE2   . GLU   A 1 152  ? 177.742 125.464 166.883 1.00 76.44  -1 152  GLU   C OE2   1 
ATOM   190  N N     . ASP   A 1 153  ? 178.091 131.948 168.055 1.00 79.37  ?  153  ASP   C N     1 
ATOM   191  C CA    . ASP   A 1 153  ? 178.152 133.180 168.847 1.00 87.91  ?  153  ASP   C CA    1 
ATOM   192  C C     . ASP   A 1 153  ? 179.278 133.128 169.874 1.00 91.31  ?  153  ASP   C C     1 
ATOM   193  O O     . ASP   A 1 153  ? 179.071 133.431 171.050 1.00 105.18 ?  153  ASP   C O     1 
ATOM   194  C CB    . ASP   A 1 153  ? 176.828 133.443 169.569 1.00 84.12  ?  153  ASP   C CB    1 
ATOM   195  C CG    . ASP   A 1 153  ? 175.689 133.714 168.626 1.00 78.71  ?  153  ASP   C CG    1 
ATOM   196  O OD1   . ASP   A 1 153  ? 175.929 134.272 167.582 1.00 78.10  ?  153  ASP   C OD1   1 
ATOM   197  O OD2   . ASP   A 1 153  ? 174.573 133.360 168.947 1.00 81.21  -1 153  ASP   C OD2   1 
ATOM   198  N N     . ARG   A 1 154  ? 180.465 132.719 169.435 1.00 94.06  ?  154  ARG   C N     1 
ATOM   199  C CA    . ARG   A 1 154  ? 181.577 132.516 170.354 1.00 98.97  ?  154  ARG   C CA    1 
ATOM   200  C C     . ARG   A 1 154  ? 182.877 133.153 169.895 1.00 100.42 ?  154  ARG   C C     1 
ATOM   201  O O     . ARG   A 1 154  ? 183.041 133.498 168.725 1.00 101.80 ?  154  ARG   C O     1 
ATOM   202  C CB    . ARG   A 1 154  ? 181.837 131.034 170.534 1.00 102.20 ?  154  ARG   C CB    1 
ATOM   203  C CG    . ARG   A 1 154  ? 182.375 130.333 169.292 1.00 98.13  ?  154  ARG   C CG    1 
ATOM   204  C CD    . ARG   A 1 154  ? 182.685 128.910 169.560 1.00 95.33  ?  154  ARG   C CD    1 
ATOM   205  N NE    . ARG   A 1 154  ? 183.124 128.212 168.354 1.00 94.65  ?  154  ARG   C NE    1 
ATOM   206  C CZ    . ARG   A 1 154  ? 184.391 128.195 167.883 1.00 97.65  ?  154  ARG   C CZ    1 
ATOM   207  N NH1   . ARG   A 1 154  ? 185.348 128.849 168.509 1.00 103.13 1  154  ARG   C NH1   1 
ATOM   208  N NH2   . ARG   A 1 154  ? 184.672 127.514 166.783 1.00 86.74  ?  154  ARG   C NH2   1 
ATOM   209  N N     . ASN   A 1 155  ? 183.815 133.251 170.833 1.00 108.90 ?  155  ASN   C N     1 
ATOM   210  C CA    . ASN   A 1 155  ? 185.193 133.627 170.559 1.00 106.90 ?  155  ASN   C CA    1 
ATOM   211  C C     . ASN   A 1 155  ? 186.012 132.372 170.279 1.00 115.08 ?  155  ASN   C C     1 
ATOM   212  O O     . ASN   A 1 155  ? 185.451 131.285 170.122 1.00 106.32 ?  155  ASN   C O     1 
ATOM   213  C CB    . ASN   A 1 155  ? 185.782 134.429 171.705 1.00 107.77 ?  155  ASN   C CB    1 
ATOM   214  C CG    . ASN   A 1 155  ? 185.843 133.662 172.991 1.00 100.61 ?  155  ASN   C CG    1 
ATOM   215  O OD1   . ASN   A 1 155  ? 185.406 132.507 173.065 1.00 99.21  ?  155  ASN   C OD1   1 
ATOM   216  N ND2   . ASN   A 1 155  ? 186.384 134.282 174.009 1.00 102.25 ?  155  ASN   C ND2   1 
ATOM   217  N N     . ALA   A 1 156  ? 187.330 132.529 170.194 1.00 109.40 ?  156  ALA   C N     1 
ATOM   218  C CA    . ALA   A 1 156  ? 188.241 131.432 169.877 1.00 106.52 ?  156  ALA   C CA    1 
ATOM   219  C C     . ALA   A 1 156  ? 187.932 130.819 168.517 1.00 109.07 ?  156  ALA   C C     1 
ATOM   220  O O     . ALA   A 1 156  ? 188.055 129.608 168.321 1.00 107.70 ?  156  ALA   C O     1 
ATOM   221  C CB    . ALA   A 1 156  ? 188.164 130.356 170.950 1.00 105.78 ?  156  ALA   C CB    1 
ATOM   222  N N     . ARG   A 1 157  ? 187.565 131.660 167.559 1.00 110.29 ?  157  ARG   C N     1 
ATOM   223  C CA    . ARG   A 1 157  ? 187.262 131.167 166.224 1.00 111.40 ?  157  ARG   C CA    1 
ATOM   224  C C     . ARG   A 1 157  ? 188.533 131.097 165.391 1.00 131.89 ?  157  ARG   C C     1 
ATOM   225  O O     . ARG   A 1 157  ? 188.754 131.919 164.504 1.00 111.85 ?  157  ARG   C O     1 
ATOM   226  C CB    . ARG   A 1 157  ? 186.262 132.079 165.541 1.00 108.34 ?  157  ARG   C CB    1 
ATOM   227  C CG    . ARG   A 1 157  ? 184.969 132.272 166.297 1.00 105.19 ?  157  ARG   C CG    1 
ATOM   228  C CD    . ARG   A 1 157  ? 184.034 133.109 165.533 1.00 105.02 ?  157  ARG   C CD    1 
ATOM   229  N NE    . ARG   A 1 157  ? 184.633 134.385 165.174 1.00 112.51 ?  157  ARG   C NE    1 
ATOM   230  C CZ    . ARG   A 1 157  ? 184.692 135.487 165.950 1.00 111.30 ?  157  ARG   C CZ    1 
ATOM   231  N NH1   . ARG   A 1 157  ? 184.183 135.499 167.163 1.00 110.37 1  157  ARG   C NH1   1 
ATOM   232  N NH2   . ARG   A 1 157  ? 185.280 136.565 165.467 1.00 111.26 ?  157  ARG   C NH2   1 
ATOM   233  N N     . LEU   A 1 158  ? 189.386 130.130 165.712 1.00 121.14 ?  158  LEU   C N     1 
ATOM   234  C CA    . LEU   A 1 158  ? 190.672 129.985 165.033 1.00 119.11 ?  158  LEU   C CA    1 
ATOM   235  C C     . LEU   A 1 158  ? 191.412 131.320 164.960 1.00 123.38 ?  158  LEU   C C     1 
ATOM   236  O O     . LEU   A 1 158  ? 191.744 131.797 163.874 1.00 125.71 ?  158  LEU   C O     1 
ATOM   237  C CB    . LEU   A 1 158  ? 190.468 129.439 163.611 1.00 127.11 ?  158  LEU   C CB    1 
ATOM   238  C CG    . LEU   A 1 158  ? 189.760 128.071 163.492 1.00 112.92 ?  158  LEU   C CG    1 
ATOM   239  C CD1   . LEU   A 1 158  ? 189.501 127.775 162.021 1.00 98.14  ?  158  LEU   C CD1   1 
ATOM   240  C CD2   . LEU   A 1 158  ? 190.631 126.979 164.113 1.00 107.49 ?  158  LEU   C CD2   1 
ATOM   241  N N     . GLY   A 1 159  ? 191.648 131.938 166.117 1.00 125.21 ?  159  GLY   C N     1 
ATOM   242  C CA    . GLY   A 1 159  ? 192.269 133.260 166.154 1.00 124.51 ?  159  GLY   C CA    1 
ATOM   243  C C     . GLY   A 1 159  ? 191.227 134.374 166.079 1.00 116.47 ?  159  GLY   C C     1 
ATOM   244  O O     . GLY   A 1 159  ? 191.547 135.515 165.748 1.00 123.04 ?  159  GLY   C O     1 
ATOM   245  N N     . GLU   A 1 160  ? 189.982 134.027 166.394 1.00 181.53 ?  160  GLU   C N     1 
ATOM   246  C CA    . GLU   A 1 160  ? 188.845 134.950 166.372 1.00 122.16 ?  160  GLU   C CA    1 
ATOM   247  C C     . GLU   A 1 160  ? 188.665 135.622 165.014 1.00 109.98 ?  160  GLU   C C     1 
ATOM   248  O O     . GLU   A 1 160  ? 188.458 136.835 164.928 1.00 117.48 ?  160  GLU   C O     1 
ATOM   249  C CB    . GLU   A 1 160  ? 188.974 136.006 167.475 1.00 124.66 ?  160  GLU   C CB    1 
ATOM   250  C CG    . GLU   A 1 160  ? 188.989 135.425 168.887 1.00 121.45 ?  160  GLU   C CG    1 
ATOM   251  C CD    . GLU   A 1 160  ? 188.832 136.462 169.980 1.00 126.57 ?  160  GLU   C CD    1 
ATOM   252  O OE1   . GLU   A 1 160  ? 188.708 137.623 169.673 1.00 128.26 ?  160  GLU   C OE1   1 
ATOM   253  O OE2   . GLU   A 1 160  ? 188.832 136.078 171.128 1.00 118.04 -1 160  GLU   C OE2   1 
ATOM   254  N N     . SER   A 1 161  ? 188.719 134.821 163.956 1.00 130.93 ?  161  SER   C N     1 
ATOM   255  C CA    . SER   A 1 161  ? 188.511 135.306 162.601 1.00 114.63 ?  161  SER   C CA    1 
ATOM   256  C C     . SER   A 1 161  ? 187.022 135.475 162.341 1.00 113.57 ?  161  SER   C C     1 
ATOM   257  O O     . SER   A 1 161  ? 186.193 135.060 163.151 1.00 108.99 ?  161  SER   C O     1 
ATOM   258  C CB    . SER   A 1 161  ? 189.121 134.350 161.594 1.00 115.34 ?  161  SER   C CB    1 
ATOM   259  O OG    . SER   A 1 161  ? 188.406 133.149 161.537 1.00 114.01 ?  161  SER   C OG    1 
ATOM   260  N N     . VAL   A 1 162  ? 186.674 136.086 161.216 1.00 113.80 ?  162  VAL   C N     1 
ATOM   261  C CA    . VAL   A 1 162  ? 185.270 136.257 160.869 1.00 105.21 ?  162  VAL   C CA    1 
ATOM   262  C C     . VAL   A 1 162  ? 184.629 134.896 160.619 1.00 101.89 ?  162  VAL   C C     1 
ATOM   263  O O     . VAL   A 1 162  ? 185.197 134.054 159.926 1.00 101.64 ?  162  VAL   C O     1 
ATOM   264  C CB    . VAL   A 1 162  ? 185.126 137.163 159.630 1.00 106.46 ?  162  VAL   C CB    1 
ATOM   265  C CG1   . VAL   A 1 162  ? 183.671 137.231 159.183 1.00 98.12  ?  162  VAL   C CG1   1 
ATOM   266  C CG2   . VAL   A 1 162  ? 185.635 138.553 159.964 1.00 104.10 ?  162  VAL   C CG2   1 
ATOM   267  N N     . SER   A 1 163  ? 183.452 134.678 161.205 1.00 96.82  ?  163  SER   C N     1 
ATOM   268  C CA    . SER   A 1 163  ? 182.765 133.393 161.117 1.00 90.22  ?  163  SER   C CA    1 
ATOM   269  C C     . SER   A 1 163  ? 182.423 133.007 159.686 1.00 83.86  ?  163  SER   C C     1 
ATOM   270  O O     . SER   A 1 163  ? 182.493 131.832 159.320 1.00 77.31  ?  163  SER   C O     1 
ATOM   271  C CB    . SER   A 1 163  ? 181.496 133.444 161.930 1.00 78.33  ?  163  SER   C CB    1 
ATOM   272  O OG    . SER   A 1 163  ? 181.783 133.593 163.288 1.00 80.92  ?  163  SER   C OG    1 
ATOM   273  N N     . LEU   A 1 164  ? 182.050 133.997 158.885 1.00 82.47  ?  164  LEU   C N     1 
ATOM   274  C CA    . LEU   A 1 164  ? 181.725 133.778 157.485 1.00 78.92  ?  164  LEU   C CA    1 
ATOM   275  C C     . LEU   A 1 164  ? 180.681 132.691 157.303 1.00 72.32  ?  164  LEU   C C     1 
ATOM   276  O O     . LEU   A 1 164  ? 180.995 131.588 156.858 1.00 73.58  ?  164  LEU   C O     1 
ATOM   277  C CB    . LEU   A 1 164  ? 182.991 133.399 156.706 1.00 83.32  ?  164  LEU   C CB    1 
ATOM   278  C CG    . LEU   A 1 164  ? 184.128 134.436 156.703 1.00 91.14  ?  164  LEU   C CG    1 
ATOM   279  C CD1   . LEU   A 1 164  ? 185.340 133.829 156.035 1.00 89.81  ?  164  LEU   C CD1   1 
ATOM   280  C CD2   . LEU   A 1 164  ? 183.682 135.701 155.974 1.00 88.36  ?  164  LEU   C CD2   1 
ATOM   281  N N     . ASN   A 1 165  ? 179.425 133.011 157.603 1.00 70.40  ?  165  ASN   C N     1 
ATOM   282  C CA    . ASN   A 1 165  ? 178.346 132.025 157.537 1.00 70.85  ?  165  ASN   C CA    1 
ATOM   283  C C     . ASN   A 1 165  ? 178.077 131.548 156.112 1.00 70.62  ?  165  ASN   C C     1 
ATOM   284  O O     . ASN   A 1 165  ? 177.257 130.658 155.890 1.00 67.71  ?  165  ASN   C O     1 
ATOM   285  C CB    . ASN   A 1 165  ? 177.070 132.551 158.164 1.00 64.03  ?  165  ASN   C CB    1 
ATOM   286  C CG    . ASN   A 1 165  ? 177.125 132.585 159.670 1.00 63.24  ?  165  ASN   C CG    1 
ATOM   287  O OD1   . ASN   A 1 165  ? 178.138 132.238 160.291 1.00 66.96  ?  165  ASN   C OD1   1 
ATOM   288  N ND2   . ASN   A 1 165  ? 176.032 132.969 160.269 1.00 58.13  ?  165  ASN   C ND2   1 
ATOM   289  N N     . LYS   A 1 166  ? 178.809 132.100 155.150 1.00 73.17  ?  166  LYS   C N     1 
ATOM   290  C CA    . LYS   A 1 166  ? 178.756 131.624 153.774 1.00 74.62  ?  166  LYS   C CA    1 
ATOM   291  C C     . LYS   A 1 166  ? 179.285 130.191 153.702 1.00 69.84  ?  166  LYS   C C     1 
ATOM   292  O O     . LYS   A 1 166  ? 179.057 129.482 152.722 1.00 65.96  ?  166  LYS   C O     1 
ATOM   293  C CB    . LYS   A 1 166  ? 179.556 132.541 152.848 1.00 78.62  ?  166  LYS   C CB    1 
ATOM   294  C CG    . LYS   A 1 166  ? 181.063 132.491 153.046 1.00 79.62  ?  166  LYS   C CG    1 
ATOM   295  C CD    . LYS   A 1 166  ? 181.773 133.484 152.127 1.00 86.37  ?  166  LYS   C CD    1 
ATOM   296  C CE    . LYS   A 1 166  ? 183.288 133.393 152.266 1.00 102.11 ?  166  LYS   C CE    1 
ATOM   297  N NZ    . LYS   A 1 166  ? 183.988 134.368 151.381 1.00 99.11  1  166  LYS   C NZ    1 
ATOM   298  N N     . ARG   A 1 167  ? 179.982 129.765 154.762 1.00 68.51  ?  167  ARG   C N     1 
ATOM   299  C CA    . ARG   A 1 167  ? 180.499 128.404 154.878 1.00 64.44  ?  167  ARG   C CA    1 
ATOM   300  C C     . ARG   A 1 167  ? 179.372 127.399 155.078 1.00 58.43  ?  167  ARG   C C     1 
ATOM   301  O O     . ARG   A 1 167  ? 179.592 126.189 155.033 1.00 56.81  ?  167  ARG   C O     1 
ATOM   302  C CB    . ARG   A 1 167  ? 181.479 128.272 156.036 1.00 60.35  ?  167  ARG   C CB    1 
ATOM   303  C CG    . ARG   A 1 167  ? 180.860 128.346 157.433 1.00 60.94  ?  167  ARG   C CG    1 
ATOM   304  C CD    . ARG   A 1 167  ? 181.863 128.070 158.504 1.00 62.76  ?  167  ARG   C CD    1 
ATOM   305  N NE    . ARG   A 1 167  ? 182.957 129.043 158.515 1.00 74.20  ?  167  ARG   C NE    1 
ATOM   306  C CZ    . ARG   A 1 167  ? 184.221 128.796 158.092 1.00 80.29  ?  167  ARG   C CZ    1 
ATOM   307  N NH1   . ARG   A 1 167  ? 184.552 127.610 157.622 1.00 68.72  1  167  ARG   C NH1   1 
ATOM   308  N NH2   . ARG   A 1 167  ? 185.134 129.750 158.150 1.00 80.88  ?  167  ARG   C NH2   1 
ATOM   309  N N     . TYR   A 1 168  ? 178.169 127.900 155.336 1.00 54.44  ?  168  TYR   C N     1 
ATOM   310  C CA    . TYR   A 1 168  ? 177.016 127.050 155.565 1.00 50.88  ?  168  TYR   C CA    1 
ATOM   311  C C     . TYR   A 1 168  ? 176.834 126.040 154.446 1.00 52.47  ?  168  TYR   C C     1 
ATOM   312  O O     . TYR   A 1 168  ? 176.837 126.380 153.261 1.00 53.99  ?  168  TYR   C O     1 
ATOM   313  C CB    . TYR   A 1 168  ? 175.757 127.906 155.695 1.00 48.97  ?  168  TYR   C CB    1 
ATOM   314  C CG    . TYR   A 1 168  ? 174.470 127.120 155.767 1.00 39.90  ?  168  TYR   C CG    1 
ATOM   315  C CD1   . TYR   A 1 168  ? 174.062 126.546 156.952 1.00 40.55  ?  168  TYR   C CD1   1 
ATOM   316  C CD2   . TYR   A 1 168  ? 173.696 126.983 154.631 1.00 40.59  ?  168  TYR   C CD2   1 
ATOM   317  C CE1   . TYR   A 1 168  ? 172.880 125.835 157.000 1.00 40.30  ?  168  TYR   C CE1   1 
ATOM   318  C CE2   . TYR   A 1 168  ? 172.517 126.278 154.676 1.00 39.45  ?  168  TYR   C CE2   1 
ATOM   319  C CZ    . TYR   A 1 168  ? 172.105 125.707 155.856 1.00 41.13  ?  168  TYR   C CZ    1 
ATOM   320  O OH    . TYR   A 1 168  ? 170.921 125.003 155.907 1.00 39.85  ?  168  TYR   C OH    1 
ATOM   321  N N     . THR   A 1 169  ? 176.664 124.790 154.836 1.00 49.35  ?  169  THR   C N     1 
ATOM   322  C CA    . THR   A 1 169  ? 176.455 123.705 153.896 1.00 47.14  ?  169  THR   C CA    1 
ATOM   323  C C     . THR   A 1 169  ? 174.995 123.298 153.934 1.00 45.71  ?  169  THR   C C     1 
ATOM   324  O O     . THR   A 1 169  ? 174.432 123.075 155.005 1.00 46.07  ?  169  THR   C O     1 
ATOM   325  C CB    . THR   A 1 169  ? 177.378 122.525 154.232 1.00 46.55  ?  169  THR   C CB    1 
ATOM   326  O OG1   . THR   A 1 169  ? 178.743 122.948 154.115 1.00 47.18  ?  169  THR   C OG1   1 
ATOM   327  C CG2   . THR   A 1 169  ? 177.137 121.361 153.296 1.00 46.48  ?  169  THR   C CG2   1 
ATOM   328  N N     . ARG   A 1 170  ? 174.368 123.248 152.769 1.00 43.75  ?  170  ARG   C N     1 
ATOM   329  C CA    . ARG   A 1 170  ? 172.938 122.993 152.695 1.00 44.31  ?  170  ARG   C CA    1 
ATOM   330  C C     . ARG   A 1 170  ? 172.548 121.648 153.286 1.00 41.28  ?  170  ARG   C C     1 
ATOM   331  O O     . ARG   A 1 170  ? 173.111 120.612 152.934 1.00 41.33  ?  170  ARG   C O     1 
ATOM   332  C CB    . ARG   A 1 170  ? 172.465 123.049 151.252 1.00 50.01  ?  170  ARG   C CB    1 
ATOM   333  C CG    . ARG   A 1 170  ? 170.959 122.972 151.062 1.00 53.38  ?  170  ARG   C CG    1 
ATOM   334  C CD    . ARG   A 1 170  ? 170.589 123.008 149.623 1.00 53.13  ?  170  ARG   C CD    1 
ATOM   335  N NE    . ARG   A 1 170  ? 170.982 124.261 148.990 1.00 54.81  ?  170  ARG   C NE    1 
ATOM   336  C CZ    . ARG   A 1 170  ? 170.270 125.407 149.028 1.00 62.94  ?  170  ARG   C CZ    1 
ATOM   337  N NH1   . ARG   A 1 170  ? 169.126 125.460 149.677 1.00 63.83  1  170  ARG   C NH1   1 
ATOM   338  N NH2   . ARG   A 1 170  ? 170.727 126.483 148.410 1.00 65.03  ?  170  ARG   C NH2   1 
ATOM   339  N N     . LEU   A 1 171  ? 171.538 121.674 154.148 1.00 36.75  ?  171  LEU   C N     1 
ATOM   340  C CA    . LEU   A 1 171  ? 170.978 120.469 154.733 1.00 28.77  ?  171  LEU   C CA    1 
ATOM   341  C C     . LEU   A 1 171  ? 169.679 120.132 154.026 1.00 29.58  ?  171  LEU   C C     1 
ATOM   342  O O     . LEU   A 1 171  ? 168.933 121.028 153.629 1.00 32.51  ?  171  LEU   C O     1 
ATOM   343  C CB    . LEU   A 1 171  ? 170.722 120.675 156.230 1.00 23.57  ?  171  LEU   C CB    1 
ATOM   344  C CG    . LEU   A 1 171  ? 171.951 121.030 157.079 1.00 27.40  ?  171  LEU   C CG    1 
ATOM   345  C CD1   . LEU   A 1 171  ? 171.500 121.401 158.485 1.00 29.01  ?  171  LEU   C CD1   1 
ATOM   346  C CD2   . LEU   A 1 171  ? 172.899 119.836 157.126 1.00 31.37  ?  171  LEU   C CD2   1 
ATOM   347  N N     . ARG   A 1 172  ? 169.411 118.846 153.865 1.00 30.29  ?  172  ARG   C N     1 
ATOM   348  C CA    . ARG   A 1 172  ? 168.186 118.396 153.224 1.00 28.54  ?  172  ARG   C CA    1 
ATOM   349  C C     . ARG   A 1 172  ? 167.069 118.218 154.237 1.00 27.34  ?  172  ARG   C C     1 
ATOM   350  O O     . ARG   A 1 172  ? 167.279 117.681 155.326 1.00 29.20  ?  172  ARG   C O     1 
ATOM   351  C CB    . ARG   A 1 172  ? 168.427 117.094 152.485 1.00 36.11  ?  172  ARG   C CB    1 
ATOM   352  C CG    . ARG   A 1 172  ? 169.363 117.203 151.294 1.00 39.05  ?  172  ARG   C CG    1 
ATOM   353  C CD    . ARG   A 1 172  ? 169.684 115.872 150.722 1.00 45.59  ?  172  ARG   C CD    1 
ATOM   354  N NE    . ARG   A 1 172  ? 170.515 115.080 151.625 1.00 44.97  ?  172  ARG   C NE    1 
ATOM   355  C CZ    . ARG   A 1 172  ? 170.809 113.775 151.458 1.00 48.39  ?  172  ARG   C CZ    1 
ATOM   356  N NH1   . ARG   A 1 172  ? 170.334 113.117 150.422 1.00 51.26  1  172  ARG   C NH1   1 
ATOM   357  N NH2   . ARG   A 1 172  ? 171.577 113.155 152.337 1.00 43.43  ?  172  ARG   C NH2   1 
ATOM   358  N N     . LEU   A 1 173  ? 165.877 118.664 153.872 1.00 24.96  ?  173  LEU   C N     1 
ATOM   359  C CA    . LEU   A 1 173  ? 164.724 118.554 154.751 1.00 23.42  ?  173  LEU   C CA    1 
ATOM   360  C C     . LEU   A 1 173  ? 163.686 117.595 154.196 1.00 26.34  ?  173  LEU   C C     1 
ATOM   361  O O     . LEU   A 1 173  ? 163.269 117.718 153.043 1.00 29.94  ?  173  LEU   C O     1 
ATOM   362  C CB    . LEU   A 1 173  ? 164.090 119.930 154.938 1.00 19.70  ?  173  LEU   C CB    1 
ATOM   363  C CG    . LEU   A 1 173  ? 165.000 121.026 155.475 1.00 18.54  ?  173  LEU   C CG    1 
ATOM   364  C CD1   . LEU   A 1 173  ? 164.209 122.323 155.545 1.00 20.64  ?  173  LEU   C CD1   1 
ATOM   365  C CD2   . LEU   A 1 173  ? 165.533 120.634 156.842 1.00 19.08  ?  173  LEU   C CD2   1 
ATOM   366  N N     . ILE   A 1 174  ? 163.268 116.640 155.018 1.00 22.39  ?  174  ILE   C N     1 
ATOM   367  C CA    . ILE   A 1 174  ? 162.274 115.663 154.596 1.00 21.22  ?  174  ILE   C CA    1 
ATOM   368  C C     . ILE   A 1 174  ? 160.979 115.791 155.373 1.00 24.23  ?  174  ILE   C C     1 
ATOM   369  O O     . ILE   A 1 174  ? 160.977 115.771 156.604 1.00 26.05  ?  174  ILE   C O     1 
ATOM   370  C CB    . ILE   A 1 174  ? 162.806 114.231 154.758 1.00 22.57  ?  174  ILE   C CB    1 
ATOM   371  C CG1   . ILE   A 1 174  ? 164.128 114.061 153.992 1.00 28.02  ?  174  ILE   C CG1   1 
ATOM   372  C CG2   . ILE   A 1 174  ? 161.764 113.222 154.291 1.00 28.69  ?  174  ILE   C CG2   1 
ATOM   373  C CD1   . ILE   A 1 174  ? 164.043 114.292 152.487 1.00 36.44  ?  174  ILE   C CD1   1 
ATOM   374  N N     . LYS   A 1 175  ? 159.868 115.888 154.657 1.00 24.85  ?  175  LYS   C N     1 
ATOM   375  C CA    . LYS   A 1 175  ? 158.570 115.935 155.314 1.00 21.80  ?  175  LYS   C CA    1 
ATOM   376  C C     . LYS   A 1 175  ? 158.199 114.531 155.786 1.00 21.44  ?  175  LYS   C C     1 
ATOM   377  O O     . LYS   A 1 175  ? 158.231 113.585 154.997 1.00 27.96  ?  175  LYS   C O     1 
ATOM   378  C CB    . LYS   A 1 175  ? 157.495 116.476 154.366 1.00 27.59  ?  175  LYS   C CB    1 
ATOM   379  C CG    . LYS   A 1 175  ? 156.105 116.624 154.997 1.00 29.76  ?  175  LYS   C CG    1 
ATOM   380  C CD    . LYS   A 1 175  ? 155.088 117.192 154.005 1.00 38.86  ?  175  LYS   C CD    1 
ATOM   381  C CE    . LYS   A 1 175  ? 153.679 117.233 154.613 1.00 49.05  ?  175  LYS   C CE    1 
ATOM   382  N NZ    . LYS   A 1 175  ? 152.644 117.698 153.621 1.00 62.70  1  175  LYS   C NZ    1 
ATOM   383  N N     . GLU   A 1 176  ? 157.857 114.391 157.072 1.00 21.68  ?  176  GLU   C N     1 
ATOM   384  C CA    . GLU   A 1 176  ? 157.499 113.098 157.659 1.00 25.19  ?  176  GLU   C CA    1 
ATOM   385  C C     . GLU   A 1 176  ? 156.132 112.631 157.159 1.00 33.15  ?  176  GLU   C C     1 
ATOM   386  O O     . GLU   A 1 176  ? 155.131 113.343 157.276 1.00 34.04  ?  176  GLU   C O     1 
ATOM   387  C CB    . GLU   A 1 176  ? 157.515 113.181 159.200 1.00 26.98  ?  176  GLU   C CB    1 
ATOM   388  C CG    . GLU   A 1 176  ? 157.269 111.835 159.958 1.00 35.74  ?  176  GLU   C CG    1 
ATOM   389  C CD    . GLU   A 1 176  ? 158.384 110.811 159.774 1.00 40.75  ?  176  GLU   C CD    1 
ATOM   390  O OE1   . GLU   A 1 176  ? 159.508 111.129 160.072 1.00 33.62  ?  176  GLU   C OE1   1 
ATOM   391  O OE2   . GLU   A 1 176  ? 158.099 109.721 159.333 1.00 42.66  -1 176  GLU   C OE2   1 
ATOM   392  N N     . SER   A 1 201  ? 160.550 112.435 150.765 1.00 29.45  ?  201  SER   C N     1 
ATOM   393  C CA    . SER   A 1 201  ? 159.621 113.518 150.464 1.00 29.25  ?  201  SER   C CA    1 
ATOM   394  C C     . SER   A 1 201  ? 160.244 114.898 150.792 1.00 31.80  ?  201  SER   C C     1 
ATOM   395  O O     . SER   A 1 201  ? 159.880 115.512 151.799 1.00 31.30  ?  201  SER   C O     1 
ATOM   396  C CB    . SER   A 1 201  ? 158.324 113.312 151.241 1.00 28.12  ?  201  SER   C CB    1 
ATOM   397  O OG    . SER   A 1 201  ? 157.685 112.129 150.845 1.00 33.28  ?  201  SER   C OG    1 
ATOM   398  N N     . PRO   A 1 202  ? 161.184 115.414 149.952 1.00 33.67  ?  202  PRO   C N     1 
ATOM   399  C CA    . PRO   A 1 202  ? 161.893 116.679 150.123 1.00 33.31  ?  202  PRO   C CA    1 
ATOM   400  C C     . PRO   A 1 202  ? 160.946 117.873 150.213 1.00 31.65  ?  202  PRO   C C     1 
ATOM   401  O O     . PRO   A 1 202  ? 159.968 117.961 149.473 1.00 29.68  ?  202  PRO   C O     1 
ATOM   402  C CB    . PRO   A 1 202  ? 162.744 116.763 148.843 1.00 33.80  ?  202  PRO   C CB    1 
ATOM   403  C CG    . PRO   A 1 202  ? 162.909 115.332 148.390 1.00 39.82  ?  202  PRO   C CG    1 
ATOM   404  C CD    . PRO   A 1 202  ? 161.604 114.672 148.719 1.00 35.48  ?  202  PRO   C CD    1 
ATOM   405  N N     . ILE   A 1 203  ? 161.273 118.790 151.113 1.00 30.18  ?  203  ILE   C N     1 
ATOM   406  C CA    . ILE   A 1 203  ? 160.501 120.015 151.304 1.00 27.32  ?  203  ILE   C CA    1 
ATOM   407  C C     . ILE   A 1 203  ? 161.427 121.217 151.196 1.00 24.25  ?  203  ILE   C C     1 
ATOM   408  O O     . ILE   A 1 203  ? 162.589 121.153 151.596 1.00 27.90  ?  203  ILE   C O     1 
ATOM   409  C CB    . ILE   A 1 203  ? 159.765 119.999 152.664 1.00 24.20  ?  203  ILE   C CB    1 
ATOM   410  C CG1   . ILE   A 1 203  ? 158.822 121.207 152.774 1.00 22.59  ?  203  ILE   C CG1   1 
ATOM   411  C CG2   . ILE   A 1 203  ? 160.765 119.992 153.804 1.00 25.08  ?  203  ILE   C CG2   1 
ATOM   412  C CD1   . ILE   A 1 203  ? 157.781 121.073 153.876 1.00 25.95  ?  203  ILE   C CD1   1 
ATOM   413  N N     . LYS   A 1 204  ? 160.923 122.309 150.639 1.00 23.90  ?  204  LYS   C N     1 
ATOM   414  C CA    . LYS   A 1 204  ? 161.729 123.506 150.479 1.00 28.21  ?  204  LYS   C CA    1 
ATOM   415  C C     . LYS   A 1 204  ? 162.037 124.144 151.824 1.00 30.17  ?  204  LYS   C C     1 
ATOM   416  O O     . LYS   A 1 204  ? 161.381 123.851 152.821 1.00 30.06  ?  204  LYS   C O     1 
ATOM   417  C CB    . LYS   A 1 204  ? 161.038 124.518 149.566 1.00 32.24  ?  204  LYS   C CB    1 
ATOM   418  C CG    . LYS   A 1 204  ? 160.917 124.079 148.114 1.00 32.65  ?  204  LYS   C CG    1 
ATOM   419  C CD    . LYS   A 1 204  ? 160.352 125.198 147.250 1.00 34.97  ?  204  LYS   C CD    1 
ATOM   420  C CE    . LYS   A 1 204  ? 160.285 124.797 145.785 1.00 42.42  ?  204  LYS   C CE    1 
ATOM   421  N NZ    . LYS   A 1 204  ? 159.803 125.916 144.922 1.00 39.78  1  204  LYS   C NZ    1 
ATOM   422  N N     . MET   A 1 205  ? 163.046 125.011 151.846 1.00 29.44  ?  205  MET   C N     1 
ATOM   423  C CA    . MET   A 1 205  ? 163.384 125.726 153.068 1.00 25.79  ?  205  MET   C CA    1 
ATOM   424  C C     . MET   A 1 205  ? 162.231 126.622 153.477 1.00 24.30  ?  205  MET   C C     1 
ATOM   425  O O     . MET   A 1 205  ? 161.934 126.780 154.658 1.00 26.30  ?  205  MET   C O     1 
ATOM   426  C CB    . MET   A 1 205  ? 164.646 126.555 152.865 1.00 32.33  ?  205  MET   C CB    1 
ATOM   427  C CG    . MET   A 1 205  ? 165.200 127.182 154.130 1.00 35.60  ?  205  MET   C CG    1 
ATOM   428  S SD    . MET   A 1 205  ? 165.896 125.978 155.260 1.00 47.08  ?  205  MET   C SD    1 
ATOM   429  C CE    . MET   A 1 205  ? 164.591 125.822 156.470 1.00 28.79  ?  205  MET   C CE    1 
ATOM   430  N N     . GLU   A 1 206  ? 161.571 127.193 152.483 1.00 23.42  ?  206  GLU   C N     1 
ATOM   431  C CA    . GLU   A 1 206  ? 160.387 127.994 152.716 1.00 22.78  ?  206  GLU   C CA    1 
ATOM   432  C C     . GLU   A 1 206  ? 159.162 127.107 152.523 1.00 26.70  ?  206  GLU   C C     1 
ATOM   433  O O     . GLU   A 1 206  ? 159.294 125.926 152.216 1.00 30.84  ?  206  GLU   C O     1 
ATOM   434  C CB    . GLU   A 1 206  ? 160.376 129.214 151.784 1.00 21.02  ?  206  GLU   C CB    1 
ATOM   435  C CG    . GLU   A 1 206  ? 160.279 128.903 150.297 1.00 28.41  ?  206  GLU   C CG    1 
ATOM   436  C CD    . GLU   A 1 206  ? 161.588 128.549 149.654 1.00 37.72  ?  206  GLU   C CD    1 
ATOM   437  O OE1   . GLU   A 1 206  ? 162.509 128.217 150.357 1.00 35.84  ?  206  GLU   C OE1   1 
ATOM   438  O OE2   . GLU   A 1 206  ? 161.665 128.607 148.449 1.00 40.01  -1 206  GLU   C OE2   1 
ATOM   439  N N     . LEU   A 1 207  ? 157.974 127.664 152.715 1.00 27.00  ?  207  LEU   C N     1 
ATOM   440  C CA    . LEU   A 1 207  ? 156.722 126.902 152.643 1.00 26.03  ?  207  LEU   C CA    1 
ATOM   441  C C     . LEU   A 1 207  ? 156.584 125.895 153.780 1.00 26.42  ?  207  LEU   C C     1 
ATOM   442  O O     . LEU   A 1 207  ? 155.798 124.956 153.676 1.00 30.48  ?  207  LEU   C O     1 
ATOM   443  C CB    . LEU   A 1 207  ? 156.605 126.093 151.336 1.00 24.15  ?  207  LEU   C CB    1 
ATOM   444  C CG    . LEU   A 1 207  ? 156.902 126.793 150.021 1.00 29.21  ?  207  LEU   C CG    1 
ATOM   445  C CD1   . LEU   A 1 207  ? 156.779 125.778 148.915 1.00 34.68  ?  207  LEU   C CD1   1 
ATOM   446  C CD2   . LEU   A 1 207  ? 155.962 127.953 149.811 1.00 32.03  ?  207  LEU   C CD2   1 
ATOM   447  N N     . LEU   A 1 208  ? 157.323 126.085 154.870 1.00 23.79  ?  208  LEU   C N     1 
ATOM   448  C CA    . LEU   A 1 208  ? 157.233 125.154 155.990 1.00 22.34  ?  208  LEU   C CA    1 
ATOM   449  C C     . LEU   A 1 208  ? 155.928 125.302 156.746 1.00 28.52  ?  208  LEU   C C     1 
ATOM   450  O O     . LEU   A 1 208  ? 155.438 124.342 157.338 1.00 29.83  ?  208  LEU   C O     1 
ATOM   451  C CB    . LEU   A 1 208  ? 158.393 125.356 156.966 1.00 20.87  ?  208  LEU   C CB    1 
ATOM   452  C CG    . LEU   A 1 208  ? 159.787 124.963 156.479 1.00 19.80  ?  208  LEU   C CG    1 
ATOM   453  C CD1   . LEU   A 1 208  ? 160.796 125.476 157.473 1.00 25.23  ?  208  LEU   C CD1   1 
ATOM   454  C CD2   . LEU   A 1 208  ? 159.898 123.448 156.358 1.00 19.37  ?  208  LEU   C CD2   1 
ATOM   455  N N     . PHE   A 1 209  ? 155.366 126.505 156.743 1.00 27.75  ?  209  PHE   C N     1 
ATOM   456  C CA    . PHE   A 1 209  ? 154.137 126.770 157.482 1.00 28.69  ?  209  PHE   C CA    1 
ATOM   457  C C     . PHE   A 1 209  ? 152.942 126.835 156.537 1.00 35.39  ?  209  PHE   C C     1 
ATOM   458  O O     . PHE   A 1 209  ? 151.785 126.829 156.964 1.00 39.99  ?  209  PHE   C O     1 
ATOM   459  C CB    . PHE   A 1 209  ? 154.274 128.090 158.236 1.00 23.01  ?  209  PHE   C CB    1 
ATOM   460  C CG    . PHE   A 1 209  ? 155.445 128.107 159.142 1.00 17.07  ?  209  PHE   C CG    1 
ATOM   461  C CD1   . PHE   A 1 209  ? 156.632 128.669 158.727 1.00 17.49  ?  209  PHE   C CD1   1 
ATOM   462  C CD2   . PHE   A 1 209  ? 155.375 127.553 160.400 1.00 20.41  ?  209  PHE   C CD2   1 
ATOM   463  C CE1   . PHE   A 1 209  ? 157.725 128.675 159.548 1.00 20.39  ?  209  PHE   C CE1   1 
ATOM   464  C CE2   . PHE   A 1 209  ? 156.473 127.556 161.227 1.00 20.85  ?  209  PHE   C CE2   1 
ATOM   465  C CZ    . PHE   A 1 209  ? 157.649 128.116 160.795 1.00 20.30  ?  209  PHE   C CZ    1 
ATOM   466  N N     . ASP   A 1 210  ? 153.232 126.912 155.246 1.00 35.84  ?  210  ASP   C N     1 
ATOM   467  C CA    . ASP   A 1 210  ? 152.195 127.061 154.238 1.00 39.14  ?  210  ASP   C CA    1 
ATOM   468  C C     . ASP   A 1 210  ? 151.233 125.885 154.239 1.00 41.90  ?  210  ASP   C C     1 
ATOM   469  O O     . ASP   A 1 210  ? 151.613 124.770 154.600 1.00 43.04  ?  210  ASP   C O     1 
ATOM   470  C CB    . ASP   A 1 210  ? 152.815 127.225 152.852 1.00 40.24  ?  210  ASP   C CB    1 
ATOM   471  C CG    . ASP   A 1 210  ? 153.367 128.615 152.625 1.00 44.23  ?  210  ASP   C CG    1 
ATOM   472  O OD1   . ASP   A 1 210  ? 153.246 129.439 153.494 1.00 42.30  ?  210  ASP   C OD1   1 
ATOM   473  O OD2   . ASP   A 1 210  ? 153.880 128.857 151.571 1.00 43.87  -1 210  ASP   C OD2   1 
ATOM   474  N N     . PRO   A 1 211  ? 149.981 126.123 153.842 1.00 49.21  ?  211  PRO   C N     1 
ATOM   475  C CA    . PRO   A 1 211  ? 148.912 125.157 153.757 1.00 56.89  ?  211  PRO   C CA    1 
ATOM   476  C C     . PRO   A 1 211  ? 149.224 124.071 152.751 1.00 57.39  ?  211  PRO   C C     1 
ATOM   477  O O     . PRO   A 1 211  ? 149.887 124.309 151.744 1.00 52.43  ?  211  PRO   C O     1 
ATOM   478  C CB    . PRO   A 1 211  ? 147.716 126.018 153.325 1.00 67.82  ?  211  PRO   C CB    1 
ATOM   479  C CG    . PRO   A 1 211  ? 148.312 127.275 152.727 1.00 65.75  ?  211  PRO   C CG    1 
ATOM   480  C CD    . PRO   A 1 211  ? 149.597 127.491 153.462 1.00 49.40  ?  211  PRO   C CD    1 
ATOM   481  N N     . ASP   A 1 212  ? 148.730 122.878 153.045 1.00 63.94  ?  212  ASP   C N     1 
ATOM   482  C CA    . ASP   A 1 212  ? 148.939 121.725 152.185 1.00 69.20  ?  212  ASP   C CA    1 
ATOM   483  C C     . ASP   A 1 212  ? 147.927 121.742 151.051 1.00 76.65  ?  212  ASP   C C     1 
ATOM   484  O O     . ASP   A 1 212  ? 147.107 122.654 150.961 1.00 76.94  ?  212  ASP   C O     1 
ATOM   485  C CB    . ASP   A 1 212  ? 148.839 120.435 153.014 1.00 71.32  ?  212  ASP   C CB    1 
ATOM   486  C CG    . ASP   A 1 212  ? 149.707 119.290 152.486 1.00 74.37  ?  212  ASP   C CG    1 
ATOM   487  O OD1   . ASP   A 1 212  ? 149.798 119.144 151.290 1.00 79.05  ?  212  ASP   C OD1   1 
ATOM   488  O OD2   . ASP   A 1 212  ? 150.294 118.591 153.286 1.00 67.78  -1 212  ASP   C OD2   1 
ATOM   489  N N     . ASP   A 1 213  ? 147.992 120.750 150.173 1.00 80.13  ?  213  ASP   C N     1 
ATOM   490  C CA    . ASP   A 1 213  ? 147.077 120.700 149.038 1.00 84.86  ?  213  ASP   C CA    1 
ATOM   491  C C     . ASP   A 1 213  ? 145.661 120.341 149.463 1.00 85.48  ?  213  ASP   C C     1 
ATOM   492  O O     . ASP   A 1 213  ? 144.688 120.775 148.844 1.00 89.19  ?  213  ASP   C O     1 
ATOM   493  C CB    . ASP   A 1 213  ? 147.561 119.695 147.989 1.00 85.45  ?  213  ASP   C CB    1 
ATOM   494  C CG    . ASP   A 1 213  ? 148.775 120.178 147.195 1.00 86.99  ?  213  ASP   C CG    1 
ATOM   495  O OD1   . ASP   A 1 213  ? 149.050 121.357 147.203 1.00 83.86  ?  213  ASP   C OD1   1 
ATOM   496  O OD2   . ASP   A 1 213  ? 149.411 119.358 146.580 1.00 89.64  -1 213  ASP   C OD2   1 
ATOM   497  N N     . GLU   A 1 214  ? 145.537 119.544 150.517 1.00 90.54  ?  214  GLU   C N     1 
ATOM   498  C CA    . GLU   A 1 214  ? 144.224 119.108 150.965 1.00 93.49  ?  214  GLU   C CA    1 
ATOM   499  C C     . GLU   A 1 214  ? 143.579 120.133 151.885 1.00 90.40  ?  214  GLU   C C     1 
ATOM   500  O O     . GLU   A 1 214  ? 144.129 120.480 152.933 1.00 87.59  ?  214  GLU   C O     1 
ATOM   501  C CB    . GLU   A 1 214  ? 144.325 117.760 151.675 1.00 97.48  ?  214  GLU   C CB    1 
ATOM   502  C CG    . GLU   A 1 214  ? 144.756 116.614 150.771 1.00 102.57 ?  214  GLU   C CG    1 
ATOM   503  C CD    . GLU   A 1 214  ? 144.805 115.293 151.484 1.00 112.38 ?  214  GLU   C CD    1 
ATOM   504  O OE1   . GLU   A 1 214  ? 144.565 115.270 152.666 1.00 109.75 ?  214  GLU   C OE1   1 
ATOM   505  O OE2   . GLU   A 1 214  ? 145.080 114.305 150.844 1.00 107.00 -1 214  GLU   C OE2   1 
ATOM   506  N N     . HIS   A 1 215  ? 142.418 120.629 151.462 1.00 91.31  ?  215  HIS   C N     1 
ATOM   507  C CA    . HIS   A 1 215  ? 141.620 121.600 152.212 1.00 89.46  ?  215  HIS   C CA    1 
ATOM   508  C C     . HIS   A 1 215  ? 142.360 122.909 152.479 1.00 86.53  ?  215  HIS   C C     1 
ATOM   509  O O     . HIS   A 1 215  ? 141.893 123.742 153.256 1.00 86.41  ?  215  HIS   C O     1 
ATOM   510  C CB    . HIS   A 1 215  ? 141.159 120.987 153.539 1.00 97.46  ?  215  HIS   C CB    1 
ATOM   511  C CG    . HIS   A 1 215  ? 140.468 119.674 153.369 1.00 96.66  ?  215  HIS   C CG    1 
ATOM   512  N ND1   . HIS   A 1 215  ? 139.241 119.553 152.752 1.00 104.51 ?  215  HIS   C ND1   1 
ATOM   513  C CD2   . HIS   A 1 215  ? 140.837 118.421 153.724 1.00 102.78 ?  215  HIS   C CD2   1 
ATOM   514  C CE1   . HIS   A 1 215  ? 138.882 118.281 152.740 1.00 109.44 ?  215  HIS   C CE1   1 
ATOM   515  N NE2   . HIS   A 1 215  ? 139.834 117.575 153.323 1.00 103.63 ?  215  HIS   C NE2   1 
ATOM   516  N N     . SER   A 1 216  ? 143.514 123.083 151.843 1.00 85.57  ?  216  SER   C N     1 
ATOM   517  C CA    . SER   A 1 216  ? 144.322 124.283 152.008 1.00 78.65  ?  216  SER   C CA    1 
ATOM   518  C C     . SER   A 1 216  ? 144.509 124.629 153.485 1.00 75.37  ?  216  SER   C C     1 
ATOM   519  O O     . SER   A 1 216  ? 144.461 125.800 153.864 1.00 71.54  ?  216  SER   C O     1 
ATOM   520  C CB    . SER   A 1 216  ? 143.680 125.453 151.283 1.00 72.12  ?  216  SER   C CB    1 
ATOM   521  O OG    . SER   A 1 216  ? 143.522 125.180 149.916 1.00 65.31  ?  216  SER   C OG    1 
ATOM   522  N N     . GLU   A 1 217  ? 144.729 123.614 154.322 1.00 74.05  ?  217  GLU   C N     1 
ATOM   523  C CA    . GLU   A 1 217  ? 144.872 123.846 155.758 1.00 70.32  ?  217  GLU   C CA    1 
ATOM   524  C C     . GLU   A 1 217  ? 146.304 124.250 156.149 1.00 66.89  ?  217  GLU   C C     1 
ATOM   525  O O     . GLU   A 1 217  ? 147.232 123.467 155.932 1.00 60.22  ?  217  GLU   C O     1 
ATOM   526  C CB    . GLU   A 1 217  ? 144.468 122.589 156.530 1.00 73.19  ?  217  GLU   C CB    1 
ATOM   527  C CG    . GLU   A 1 217  ? 144.504 122.748 158.044 1.00 66.61  ?  217  GLU   C CG    1 
ATOM   528  C CD    . GLU   A 1 217  ? 144.090 121.505 158.772 1.00 69.09  ?  217  GLU   C CD    1 
ATOM   529  O OE1   . GLU   A 1 217  ? 143.804 120.525 158.130 1.00 67.13  ?  217  GLU   C OE1   1 
ATOM   530  O OE2   . GLU   A 1 217  ? 144.053 121.537 159.978 1.00 71.07  -1 217  GLU   C OE2   1 
ATOM   531  N N     . PRO   A 1 218  ? 146.492 125.448 156.748 1.00 62.69  ?  218  PRO   C N     1 
ATOM   532  C CA    . PRO   A 1 218  ? 147.752 126.048 157.177 1.00 54.26  ?  218  PRO   C CA    1 
ATOM   533  C C     . PRO   A 1 218  ? 148.276 125.390 158.442 1.00 48.68  ?  218  PRO   C C     1 
ATOM   534  O O     . PRO   A 1 218  ? 147.495 124.863 159.233 1.00 49.86  ?  218  PRO   C O     1 
ATOM   535  C CB    . PRO   A 1 218  ? 147.354 127.503 157.432 1.00 52.75  ?  218  PRO   C CB    1 
ATOM   536  C CG    . PRO   A 1 218  ? 145.910 127.428 157.864 1.00 53.87  ?  218  PRO   C CG    1 
ATOM   537  C CD    . PRO   A 1 218  ? 145.314 126.280 157.066 1.00 62.78  ?  218  PRO   C CD    1 
ATOM   538  N N     . VAL   A 1 219  ? 149.585 125.458 158.661 1.00 37.11  ?  219  VAL   C N     1 
ATOM   539  C CA    . VAL   A 1 219  ? 150.156 124.893 159.873 1.00 25.60  ?  219  VAL   C CA    1 
ATOM   540  C C     . VAL   A 1 219  ? 150.866 125.937 160.716 1.00 23.33  ?  219  VAL   C C     1 
ATOM   541  O O     . VAL   A 1 219  ? 151.802 126.587 160.262 1.00 26.12  ?  219  VAL   C O     1 
ATOM   542  C CB    . VAL   A 1 219  ? 151.133 123.769 159.515 1.00 28.18  ?  219  VAL   C CB    1 
ATOM   543  C CG1   . VAL   A 1 219  ? 151.754 123.207 160.773 1.00 30.26  ?  219  VAL   C CG1   1 
ATOM   544  C CG2   . VAL   A 1 219  ? 150.389 122.684 158.756 1.00 35.29  ?  219  VAL   C CG2   1 
ATOM   545  N N     . HIS   A 1 220  ? 150.430 126.076 161.957 1.00 24.76  ?  220  HIS   C N     1 
ATOM   546  C CA    . HIS   A 1 220  ? 151.018 127.048 162.864 1.00 21.60  ?  220  HIS   C CA    1 
ATOM   547  C C     . HIS   A 1 220  ? 152.317 126.548 163.472 1.00 23.00  ?  220  HIS   C C     1 
ATOM   548  O O     . HIS   A 1 220  ? 153.218 127.337 163.756 1.00 26.21  ?  220  HIS   C O     1 
ATOM   549  C CB    . HIS   A 1 220  ? 150.044 127.370 163.989 1.00 23.16  ?  220  HIS   C CB    1 
ATOM   550  C CG    . HIS   A 1 220  ? 148.810 128.015 163.519 1.00 25.60  ?  220  HIS   C CG    1 
ATOM   551  N ND1   . HIS   A 1 220  ? 147.775 127.304 162.952 1.00 37.40  ?  220  HIS   C ND1   1 
ATOM   552  C CD2   . HIS   A 1 220  ? 148.425 129.305 163.523 1.00 32.08  ?  220  HIS   C CD2   1 
ATOM   553  C CE1   . HIS   A 1 220  ? 146.800 128.137 162.631 1.00 39.38  ?  220  HIS   C CE1   1 
ATOM   554  N NE2   . HIS   A 1 220  ? 147.170 129.356 162.969 1.00 35.40  ?  220  HIS   C NE2   1 
ATOM   555  N N     . THR   A 1 221  ? 152.407 125.244 163.699 1.00 20.10  ?  221  THR   C N     1 
ATOM   556  C CA    . THR   A 1 221  ? 153.572 124.695 164.378 1.00 16.97  ?  221  THR   C CA    1 
ATOM   557  C C     . THR   A 1 221  ? 154.327 123.697 163.521 1.00 20.31  ?  221  THR   C C     1 
ATOM   558  O O     . THR   A 1 221  ? 153.754 122.739 163.000 1.00 26.30  ?  221  THR   C O     1 
ATOM   559  C CB    . THR   A 1 221  ? 153.175 124.025 165.706 1.00 18.61  ?  221  THR   C CB    1 
ATOM   560  O OG1   . THR   A 1 221  ? 152.550 124.989 166.559 1.00 25.75  ?  221  THR   C OG1   1 
ATOM   561  C CG2   . THR   A 1 221  ? 154.411 123.476 166.406 1.00 21.58  ?  221  THR   C CG2   1 
ATOM   562  N N     . VAL   A 1 222  ? 155.622 123.924 163.400 1.00 17.09  ?  222  VAL   C N     1 
ATOM   563  C CA    . VAL   A 1 222  ? 156.508 123.047 162.652 1.00 0.00   ?  222  VAL   C CA    1 
ATOM   564  C C     . VAL   A 1 222  ? 157.622 122.569 163.555 1.00 21.80  ?  222  VAL   C C     1 
ATOM   565  O O     . VAL   A 1 222  ? 158.226 123.363 164.274 1.00 20.21  ?  222  VAL   C O     1 
ATOM   566  C CB    . VAL   A 1 222  ? 157.097 123.777 161.435 1.00 17.35  ?  222  VAL   C CB    1 
ATOM   567  C CG1   . VAL   A 1 222  ? 158.078 122.873 160.691 1.00 19.36  ?  222  VAL   C CG1   1 
ATOM   568  C CG2   . VAL   A 1 222  ? 155.975 124.195 160.519 1.00 23.97  ?  222  VAL   C CG2   1 
ATOM   569  N N     . VAL   A 1 223  ? 157.870 121.275 163.552 1.00 25.22  ?  223  VAL   C N     1 
ATOM   570  C CA    . VAL   A 1 223  ? 158.902 120.734 164.411 1.00 0.02   ?  223  VAL   C CA    1 
ATOM   571  C C     . VAL   A 1 223  ? 160.010 120.068 163.620 1.00 7.79   ?  223  VAL   C C     1 
ATOM   572  O O     . VAL   A 1 223  ? 159.775 119.109 162.884 1.00 15.89  ?  223  VAL   C O     1 
ATOM   573  C CB    . VAL   A 1 223  ? 158.289 119.723 165.388 1.00 6.98   ?  223  VAL   C CB    1 
ATOM   574  C CG1   . VAL   A 1 223  ? 159.368 119.141 166.298 1.00 12.99  ?  223  VAL   C CG1   1 
ATOM   575  C CG2   . VAL   A 1 223  ? 157.218 120.414 166.197 1.00 15.39  ?  223  VAL   C CG2   1 
ATOM   576  N N     . PHE   A 1 224  ? 161.225 120.564 163.799 1.00 8.73   ?  224  PHE   C N     1 
ATOM   577  C CA    . PHE   A 1 224  ? 162.387 119.947 163.196 1.00 6.29   ?  224  PHE   C CA    1 
ATOM   578  C C     . PHE   A 1 224  ? 162.964 118.939 164.156 1.00 10.91  ?  224  PHE   C C     1 
ATOM   579  O O     . PHE   A 1 224  ? 163.082 119.214 165.352 1.00 16.62  ?  224  PHE   C O     1 
ATOM   580  C CB    . PHE   A 1 224  ? 163.488 120.956 162.873 1.00 6.51   ?  224  PHE   C CB    1 
ATOM   581  C CG    . PHE   A 1 224  ? 163.290 121.799 161.664 1.00 5.93   ?  224  PHE   C CG    1 
ATOM   582  C CD1   . PHE   A 1 224  ? 163.362 123.171 161.746 1.00 6.68   ?  224  PHE   C CD1   1 
ATOM   583  C CD2   . PHE   A 1 224  ? 163.056 121.224 160.432 1.00 11.34  ?  224  PHE   C CD2   1 
ATOM   584  C CE1   . PHE   A 1 224  ? 163.206 123.945 160.623 1.00 11.05  ?  224  PHE   C CE1   1 
ATOM   585  C CE2   . PHE   A 1 224  ? 162.897 122.004 159.318 1.00 15.67  ?  224  PHE   C CE2   1 
ATOM   586  C CZ    . PHE   A 1 224  ? 162.974 123.360 159.415 1.00 15.51  ?  224  PHE   C CZ    1 
ATOM   587  N N     . GLN   A 1 225  ? 163.383 117.799 163.642 1.00 12.91  ?  225  GLN   C N     1 
ATOM   588  C CA    . GLN   A 1 225  ? 164.037 116.840 164.507 1.00 14.06  ?  225  GLN   C CA    1 
ATOM   589  C C     . GLN   A 1 225  ? 165.281 116.269 163.865 1.00 17.93  ?  225  GLN   C C     1 
ATOM   590  O O     . GLN   A 1 225  ? 165.368 116.137 162.643 1.00 22.05  ?  225  GLN   C O     1 
ATOM   591  C CB    . GLN   A 1 225  ? 163.076 115.718 164.895 1.00 15.83  ?  225  GLN   C CB    1 
ATOM   592  C CG    . GLN   A 1 225  ? 162.613 114.873 163.734 1.00 18.51  ?  225  GLN   C CG    1 
ATOM   593  C CD    . GLN   A 1 225  ? 161.567 113.863 164.136 1.00 24.23  ?  225  GLN   C CD    1 
ATOM   594  O OE1   . GLN   A 1 225  ? 160.446 114.229 164.500 1.00 22.72  ?  225  GLN   C OE1   1 
ATOM   595  N NE2   . GLN   A 1 225  ? 161.922 112.585 164.075 1.00 28.55  ?  225  GLN   C NE2   1 
ATOM   596  N N     . GLY   A 1 226  ? 166.240 115.895 164.699 1.00 19.87  ?  226  GLY   C N     1 
ATOM   597  C CA    . GLY   A 1 226  ? 167.450 115.270 164.185 1.00 20.74  ?  226  GLY   C CA    1 
ATOM   598  C C     . GLY   A 1 226  ? 168.461 114.919 165.267 1.00 23.28  ?  226  GLY   C C     1 
ATOM   599  O O     . GLY   A 1 226  ? 168.291 115.259 166.440 1.00 28.00  ?  226  GLY   C O     1 
ATOM   600  N N     . ALA   A 1 227  ? 169.510 114.222 164.851 1.00 22.27  ?  227  ALA   C N     1 
ATOM   601  C CA    . ALA   A 1 227  ? 170.558 113.723 165.735 1.00 25.57  ?  227  ALA   C CA    1 
ATOM   602  C C     . ALA   A 1 227  ? 171.422 114.837 166.290 1.00 24.64  ?  227  ALA   C C     1 
ATOM   603  O O     . ALA   A 1 227  ? 171.530 115.914 165.705 1.00 26.55  ?  227  ALA   C O     1 
ATOM   604  C CB    . ALA   A 1 227  ? 171.441 112.737 164.988 1.00 38.23  ?  227  ALA   C CB    1 
ATOM   605  N N     . ALA   A 1 228  ? 172.057 114.572 167.421 1.00 24.20  ?  228  ALA   C N     1 
ATOM   606  C CA    . ALA   A 1 228  ? 172.997 115.530 167.967 1.00 24.85  ?  228  ALA   C CA    1 
ATOM   607  C C     . ALA   A 1 228  ? 174.099 115.782 166.958 1.00 24.23  ?  228  ALA   C C     1 
ATOM   608  O O     . ALA   A 1 228  ? 174.670 114.843 166.406 1.00 29.12  ?  228  ALA   C O     1 
ATOM   609  C CB    . ALA   A 1 228  ? 173.591 115.012 169.262 1.00 31.96  ?  228  ALA   C CB    1 
ATOM   610  N N     . GLY   A 1 229  ? 174.409 117.047 166.729 1.00 27.25  ?  229  GLY   C N     1 
ATOM   611  C CA    . GLY   A 1 229  ? 175.477 117.413 165.812 1.00 28.94  ?  229  GLY   C CA    1 
ATOM   612  C C     . GLY   A 1 229  ? 175.001 117.520 164.365 1.00 30.20  ?  229  GLY   C C     1 
ATOM   613  O O     . GLY   A 1 229  ? 175.788 117.847 163.476 1.00 33.80  ?  229  GLY   C O     1 
ATOM   614  N N     . ILE   A 1 230  ? 173.720 117.241 164.129 1.00 25.79  ?  230  ILE   C N     1 
ATOM   615  C CA    . ILE   A 1 230  ? 173.164 117.299 162.781 1.00 23.47  ?  230  ILE   C CA    1 
ATOM   616  C C     . ILE   A 1 230  ? 173.086 118.732 162.274 1.00 22.01  ?  230  ILE   C C     1 
ATOM   617  O O     . ILE   A 1 230  ? 173.042 118.967 161.070 1.00 26.77  ?  230  ILE   C O     1 
ATOM   618  C CB    . ILE   A 1 230  ? 171.776 116.640 162.711 1.00 26.53  ?  230  ILE   C CB    1 
ATOM   619  C CG1   . ILE   A 1 230  ? 171.406 116.262 161.269 1.00 26.93  ?  230  ILE   C CG1   1 
ATOM   620  C CG2   . ILE   A 1 230  ? 170.734 117.568 163.257 1.00 35.64  ?  230  ILE   C CG2   1 
ATOM   621  C CD1   . ILE   A 1 230  ? 172.250 115.161 160.673 1.00 37.18  ?  230  ILE   C CD1   1 
ATOM   622  N N     . GLY   A 1 231  ? 173.057 119.694 163.193 1.00 21.58  ?  231  GLY   C N     1 
ATOM   623  C CA    . GLY   A 1 231  ? 173.021 121.095 162.800 1.00 25.65  ?  231  GLY   C CA    1 
ATOM   624  C C     . GLY   A 1 231  ? 171.668 121.762 163.012 1.00 24.67  ?  231  GLY   C C     1 
ATOM   625  O O     . GLY   A 1 231  ? 171.388 122.797 162.407 1.00 29.32  ?  231  GLY   C O     1 
ATOM   626  N N     . LYS   A 1 232  ? 170.838 121.210 163.885 1.00 22.08  ?  232  LYS   C N     1 
ATOM   627  C CA    . LYS   A 1 232  ? 169.534 121.810 164.153 1.00 19.92  ?  232  LYS   C CA    1 
ATOM   628  C C     . LYS   A 1 232  ? 169.659 123.290 164.483 1.00 27.91  ?  232  LYS   C C     1 
ATOM   629  O O     . LYS   A 1 232  ? 168.894 124.119 163.983 1.00 30.07  ?  232  LYS   C O     1 
ATOM   630  C CB    . LYS   A 1 232  ? 168.848 121.123 165.329 1.00 19.42  ?  232  LYS   C CB    1 
ATOM   631  C CG    . LYS   A 1 232  ? 168.439 119.692 165.100 1.00 22.50  ?  232  LYS   C CG    1 
ATOM   632  C CD    . LYS   A 1 232  ? 167.612 119.144 166.255 1.00 21.95  ?  232  LYS   C CD    1 
ATOM   633  C CE    . LYS   A 1 232  ? 168.444 118.919 167.511 1.00 23.18  ?  232  LYS   C CE    1 
ATOM   634  N NZ    . LYS   A 1 232  ? 169.466 117.867 167.314 1.00 26.39  1  232  LYS   C NZ    1 
ATOM   635  N N     . THR   A 1 233  ? 170.616 123.614 165.343 1.00 28.67  ?  233  THR   C N     1 
ATOM   636  C CA    . THR   A 1 233  ? 170.802 124.978 165.809 1.00 24.53  ?  233  THR   C CA    1 
ATOM   637  C C     . THR   A 1 233  ? 171.311 125.894 164.700 1.00 26.05  ?  233  THR   C C     1 
ATOM   638  O O     . THR   A 1 233  ? 170.998 127.085 164.674 1.00 28.47  ?  233  THR   C O     1 
ATOM   639  C CB    . THR   A 1 233  ? 171.753 125.001 167.022 1.00 23.61  ?  233  THR   C CB    1 
ATOM   640  O OG1   . THR   A 1 233  ? 171.833 126.326 167.533 1.00 26.05  ?  233  THR   C OG1   1 
ATOM   641  C CG2   . THR   A 1 233  ? 173.144 124.519 166.648 1.00 33.85  ?  233  THR   C CG2   1 
ATOM   642  N N     . ILE   A 1 234  ? 172.097 125.345 163.781 1.00 25.95  ?  234  ILE   C N     1 
ATOM   643  C CA    . ILE   A 1 234  ? 172.647 126.143 162.698 1.00 21.78  ?  234  ILE   C CA    1 
ATOM   644  C C     . ILE   A 1 234  ? 171.580 126.418 161.665 1.00 22.59  ?  234  ILE   C C     1 
ATOM   645  O O     . ILE   A 1 234  ? 171.504 127.519 161.123 1.00 29.23  ?  234  ILE   C O     1 
ATOM   646  C CB    . ILE   A 1 234  ? 173.862 125.473 162.046 1.00 21.74  ?  234  ILE   C CB    1 
ATOM   647  C CG1   . ILE   A 1 234  ? 174.967 125.248 163.099 1.00 32.06  ?  234  ILE   C CG1   1 
ATOM   648  C CG2   . ILE   A 1 234  ? 174.378 126.326 160.885 1.00 22.14  ?  234  ILE   C CG2   1 
ATOM   649  C CD1   . ILE   A 1 234  ? 175.338 126.482 163.905 1.00 40.53  ?  234  ILE   C CD1   1 
ATOM   650  N N     . LEU   A 1 235  ? 170.754 125.421 161.387 1.00 21.48  ?  235  LEU   C N     1 
ATOM   651  C CA    . LEU   A 1 235  ? 169.663 125.610 160.455 1.00 20.20  ?  235  LEU   C CA    1 
ATOM   652  C C     . LEU   A 1 235  ? 168.753 126.725 160.958 1.00 24.84  ?  235  LEU   C C     1 
ATOM   653  O O     . LEU   A 1 235  ? 168.301 127.567 160.181 1.00 28.27  ?  235  LEU   C O     1 
ATOM   654  C CB    . LEU   A 1 235  ? 168.857 124.319 160.305 1.00 21.19  ?  235  LEU   C CB    1 
ATOM   655  C CG    . LEU   A 1 235  ? 167.697 124.353 159.298 1.00 21.70  ?  235  LEU   C CG    1 
ATOM   656  C CD1   . LEU   A 1 235  ? 168.236 124.578 157.893 1.00 23.18  ?  235  LEU   C CD1   1 
ATOM   657  C CD2   . LEU   A 1 235  ? 166.928 123.050 159.386 1.00 21.96  ?  235  LEU   C CD2   1 
ATOM   658  N N     . ALA   A 1 236  ? 168.495 126.732 162.268 1.00 23.26  ?  236  ALA   C N     1 
ATOM   659  C CA    . ALA   A 1 236  ? 167.666 127.767 162.869 1.00 21.21  ?  236  ALA   C CA    1 
ATOM   660  C C     . ALA   A 1 236  ? 168.300 129.147 162.697 1.00 23.59  ?  236  ALA   C C     1 
ATOM   661  O O     . ALA   A 1 236  ? 167.616 130.113 162.360 1.00 26.77  ?  236  ALA   C O     1 
ATOM   662  C CB    . ALA   A 1 236  ? 167.450 127.472 164.339 1.00 22.85  ?  236  ALA   C CB    1 
ATOM   663  N N     . ARG   A 1 237  ? 169.618 129.230 162.891 1.00 23.33  ?  237  ARG   C N     1 
ATOM   664  C CA    . ARG   A 1 237  ? 170.309 130.501 162.703 1.00 22.16  ?  237  ARG   C CA    1 
ATOM   665  C C     . ARG   A 1 237  ? 170.228 130.957 161.260 1.00 20.72  ?  237  ARG   C C     1 
ATOM   666  O O     . ARG   A 1 237  ? 170.033 132.145 160.990 1.00 25.44  ?  237  ARG   C O     1 
ATOM   667  C CB    . ARG   A 1 237  ? 171.772 130.392 163.086 1.00 22.71  ?  237  ARG   C CB    1 
ATOM   668  C CG    . ARG   A 1 237  ? 172.055 130.290 164.555 1.00 25.16  ?  237  ARG   C CG    1 
ATOM   669  C CD    . ARG   A 1 237  ? 173.509 130.196 164.800 1.00 34.70  ?  237  ARG   C CD    1 
ATOM   670  N NE    . ARG   A 1 237  ? 173.811 129.999 166.192 1.00 47.57  ?  237  ARG   C NE    1 
ATOM   671  C CZ    . ARG   A 1 237  ? 173.850 130.978 167.104 1.00 49.63  ?  237  ARG   C CZ    1 
ATOM   672  N NH1   . ARG   A 1 237  ? 173.593 132.213 166.754 1.00 49.39  1  237  ARG   C NH1   1 
ATOM   673  N NH2   . ARG   A 1 237  ? 174.145 130.711 168.359 1.00 59.93  ?  237  ARG   C NH2   1 
ATOM   674  N N     . LYS   A 1 238  ? 170.370 130.025 160.329 1.00 22.31  ?  238  LYS   C N     1 
ATOM   675  C CA    . LYS   A 1 238  ? 170.318 130.378 158.924 1.00 20.71  ?  238  LYS   C CA    1 
ATOM   676  C C     . LYS   A 1 238  ? 168.957 130.952 158.583 1.00 24.33  ?  238  LYS   C C     1 
ATOM   677  O O     . LYS   A 1 238  ? 168.869 131.967 157.892 1.00 30.02  ?  238  LYS   C O     1 
ATOM   678  C CB    . LYS   A 1 238  ? 170.614 129.170 158.040 1.00 29.19  ?  238  LYS   C CB    1 
ATOM   679  C CG    . LYS   A 1 238  ? 170.645 129.469 156.545 1.00 27.20  ?  238  LYS   C CG    1 
ATOM   680  C CD    . LYS   A 1 238  ? 171.824 130.359 156.179 1.00 29.84  ?  238  LYS   C CD    1 
ATOM   681  C CE    . LYS   A 1 238  ? 172.097 130.339 154.677 1.00 38.07  ?  238  LYS   C CE    1 
ATOM   682  N NZ    . LYS   A 1 238  ? 171.050 131.071 153.894 1.00 37.23  1  238  LYS   C NZ    1 
ATOM   683  N N     . MET   A 1 239  ? 167.892 130.333 159.086 1.00 22.30  ?  239  MET   C N     1 
ATOM   684  C CA    . MET   A 1 239  ? 166.561 130.852 158.817 1.00 24.39  ?  239  MET   C CA    1 
ATOM   685  C C     . MET   A 1 239  ? 166.419 132.264 159.347 1.00 23.24  ?  239  MET   C C     1 
ATOM   686  O O     . MET   A 1 239  ? 165.887 133.142 158.668 1.00 25.39  ?  239  MET   C O     1 
ATOM   687  C CB    . MET   A 1 239  ? 165.487 129.971 159.436 1.00 22.86  ?  239  MET   C CB    1 
ATOM   688  C CG    . MET   A 1 239  ? 165.316 128.634 158.774 1.00 25.34  ?  239  MET   C CG    1 
ATOM   689  S SD    . MET   A 1 239  ? 164.093 127.609 159.597 1.00 35.29  ?  239  MET   C SD    1 
ATOM   690  C CE    . MET   A 1 239  ? 162.567 128.417 159.107 1.00 24.72  ?  239  MET   C CE    1 
ATOM   691  N N     . MET   A 1 240  ? 166.917 132.491 160.552 1.00 20.70  ?  240  MET   C N     1 
ATOM   692  C CA    . MET   A 1 240  ? 166.826 133.805 161.147 1.00 18.81  ?  240  MET   C CA    1 
ATOM   693  C C     . MET   A 1 240  ? 167.525 134.855 160.292 1.00 23.13  ?  240  MET   C C     1 
ATOM   694  O O     . MET   A 1 240  ? 166.985 135.937 160.056 1.00 27.59  ?  240  MET   C O     1 
ATOM   695  C CB    . MET   A 1 240  ? 167.422 133.777 162.545 1.00 22.36  ?  240  MET   C CB    1 
ATOM   696  C CG    . MET   A 1 240  ? 167.352 135.079 163.249 1.00 23.94  ?  240  MET   C CG    1 
ATOM   697  S SD    . MET   A 1 240  ? 165.678 135.598 163.567 1.00 38.13  ?  240  MET   C SD    1 
ATOM   698  C CE    . MET   A 1 240  ? 165.381 134.822 165.128 1.00 29.41  ?  240  MET   C CE    1 
ATOM   699  N N     . LEU   A 1 241  ? 168.720 134.531 159.809 1.00 22.23  ?  241  LEU   C N     1 
ATOM   700  C CA    . LEU   A 1 241  ? 169.476 135.468 158.993 1.00 18.54  ?  241  LEU   C CA    1 
ATOM   701  C C     . LEU   A 1 241  ? 168.820 135.701 157.640 1.00 22.03  ?  241  LEU   C C     1 
ATOM   702  O O     . LEU   A 1 241  ? 168.701 136.842 157.194 1.00 27.28  ?  241  LEU   C O     1 
ATOM   703  C CB    . LEU   A 1 241  ? 170.906 134.955 158.802 1.00 18.45  ?  241  LEU   C CB    1 
ATOM   704  C CG    . LEU   A 1 241  ? 171.854 135.830 157.956 1.00 19.65  ?  241  LEU   C CG    1 
ATOM   705  C CD1   . LEU   A 1 241  ? 171.984 137.218 158.577 1.00 34.34  ?  241  LEU   C CD1   1 
ATOM   706  C CD2   . LEU   A 1 241  ? 173.216 135.149 157.889 1.00 26.73  ?  241  LEU   C CD2   1 
ATOM   707  N N     . ASP   A 1 242  ? 168.369 134.630 156.990 1.00 23.63  ?  242  ASP   C N     1 
ATOM   708  C CA    . ASP   A 1 242  ? 167.737 134.778 155.683 1.00 24.45  ?  242  ASP   C CA    1 
ATOM   709  C C     . ASP   A 1 242  ? 166.490 135.638 155.787 1.00 26.83  ?  242  ASP   C C     1 
ATOM   710  O O     . ASP   A 1 242  ? 166.173 136.405 154.874 1.00 28.66  ?  242  ASP   C O     1 
ATOM   711  C CB    . ASP   A 1 242  ? 167.382 133.420 155.079 1.00 28.43  ?  242  ASP   C CB    1 
ATOM   712  C CG    . ASP   A 1 242  ? 168.593 132.652 154.567 1.00 33.93  ?  242  ASP   C CG    1 
ATOM   713  O OD1   . ASP   A 1 242  ? 169.649 133.231 154.448 1.00 30.92  ?  242  ASP   C OD1   1 
ATOM   714  O OD2   . ASP   A 1 242  ? 168.460 131.483 154.279 1.00 33.52  -1 242  ASP   C OD2   1 
ATOM   715  N N     . TRP   A 1 243  ? 165.782 135.521 156.902 1.00 24.40  ?  243  TRP   C N     1 
ATOM   716  C CA    . TRP   A 1 243  ? 164.639 136.384 157.133 1.00 22.62  ?  243  TRP   C CA    1 
ATOM   717  C C     . TRP   A 1 243  ? 165.065 137.830 157.304 1.00 22.05  ?  243  TRP   C C     1 
ATOM   718  O O     . TRP   A 1 243  ? 164.513 138.733 156.675 1.00 26.91  ?  243  TRP   C O     1 
ATOM   719  C CB    . TRP   A 1 243  ? 163.864 135.950 158.361 1.00 24.58  ?  243  TRP   C CB    1 
ATOM   720  C CG    . TRP   A 1 243  ? 162.859 136.946 158.725 1.00 20.53  ?  243  TRP   C CG    1 
ATOM   721  C CD1   . TRP   A 1 243  ? 161.631 137.095 158.181 1.00 24.98  ?  243  TRP   C CD1   1 
ATOM   722  C CD2   . TRP   A 1 243  ? 162.978 137.962 159.726 1.00 20.64  ?  243  TRP   C CD2   1 
ATOM   723  N NE1   . TRP   A 1 243  ? 160.982 138.135 158.769 1.00 26.76  ?  243  TRP   C NE1   1 
ATOM   724  C CE2   . TRP   A 1 243  ? 161.793 138.681 159.709 1.00 23.27  ?  243  TRP   C CE2   1 
ATOM   725  C CE3   . TRP   A 1 243  ? 163.987 138.327 160.614 1.00 23.96  ?  243  TRP   C CE3   1 
ATOM   726  C CZ2   . TRP   A 1 243  ? 161.577 139.732 160.544 1.00 26.20  ?  243  TRP   C CZ2   1 
ATOM   727  C CZ3   . TRP   A 1 243  ? 163.766 139.395 161.458 1.00 28.21  ?  243  TRP   C CZ3   1 
ATOM   728  C CH2   . TRP   A 1 243  ? 162.592 140.081 161.417 1.00 29.72  ?  243  TRP   C CH2   1 
ATOM   729  N N     . ALA   A 1 244  ? 166.060 138.061 158.151 1.00 22.79  ?  244  ALA   C N     1 
ATOM   730  C CA    . ALA   A 1 244  ? 166.509 139.418 158.431 1.00 27.48  ?  244  ALA   C CA    1 
ATOM   731  C C     . ALA   A 1 244  ? 166.989 140.108 157.160 1.00 27.69  ?  244  ALA   C C     1 
ATOM   732  O O     . ALA   A 1 244  ? 166.806 141.314 156.989 1.00 30.12  ?  244  ALA   C O     1 
ATOM   733  C CB    . ALA   A 1 244  ? 167.609 139.396 159.472 1.00 30.21  ?  244  ALA   C CB    1 
ATOM   734  N N     . SER   A 1 245  ? 167.575 139.332 156.255 1.00 24.73  ?  245  SER   C N     1 
ATOM   735  C CA    . SER   A 1 245  ? 168.081 139.846 154.988 1.00 24.46  ?  245  SER   C CA    1 
ATOM   736  C C     . SER   A 1 245  ? 166.976 140.076 153.958 1.00 22.77  ?  245  SER   C C     1 
ATOM   737  O O     . SER   A 1 245  ? 167.239 140.588 152.870 1.00 26.50  ?  245  SER   C O     1 
ATOM   738  C CB    . SER   A 1 245  ? 169.118 138.900 154.418 1.00 29.37  ?  245  SER   C CB    1 
ATOM   739  O OG    . SER   A 1 245  ? 170.277 138.884 155.207 1.00 31.18  ?  245  SER   C OG    1 
ATOM   740  N N     . GLY   A 1 246  ? 165.746 139.697 154.289 1.00 22.91  ?  246  GLY   C N     1 
ATOM   741  C CA    . GLY   A 1 246  ? 164.613 139.916 153.401 1.00 25.05  ?  246  GLY   C CA    1 
ATOM   742  C C     . GLY   A 1 246  ? 164.461 138.869 152.305 1.00 26.97  ?  246  GLY   C C     1 
ATOM   743  O O     . GLY   A 1 246  ? 163.903 139.160 151.247 1.00 28.61  ?  246  GLY   C O     1 
ATOM   744  N N     . THR   A 1 247  ? 164.950 137.654 152.538 1.00 26.25  ?  247  THR   C N     1 
ATOM   745  C CA    . THR   A 1 247  ? 164.822 136.608 151.529 1.00 24.03  ?  247  THR   C CA    1 
ATOM   746  C C     . THR   A 1 247  ? 163.805 135.545 151.934 1.00 24.56  ?  247  THR   C C     1 
ATOM   747  O O     . THR   A 1 247  ? 163.046 135.053 151.099 1.00 25.10  ?  247  THR   C O     1 
ATOM   748  C CB    . THR   A 1 247  ? 166.179 135.938 151.250 1.00 26.59  ?  247  THR   C CB    1 
ATOM   749  O OG1   . THR   A 1 247  ? 167.101 136.915 150.755 1.00 30.27  ?  247  THR   C OG1   1 
ATOM   750  C CG2   . THR   A 1 247  ? 166.021 134.833 150.221 1.00 25.80  ?  247  THR   C CG2   1 
ATOM   751  N N     . LEU   A 1 248  ? 163.800 135.182 153.210 1.00 25.87  ?  248  LEU   C N     1 
ATOM   752  C CA    . LEU   A 1 248  ? 162.921 134.123 153.698 1.00 20.59  ?  248  LEU   C CA    1 
ATOM   753  C C     . LEU   A 1 248  ? 161.712 134.681 154.437 1.00 20.80  ?  248  LEU   C C     1 
ATOM   754  O O     . LEU   A 1 248  ? 161.854 135.467 155.368 1.00 25.87  ?  248  LEU   C O     1 
ATOM   755  C CB    . LEU   A 1 248  ? 163.708 133.179 154.609 1.00 21.46  ?  248  LEU   C CB    1 
ATOM   756  C CG    . LEU   A 1 248  ? 162.909 132.084 155.302 1.00 23.01  ?  248  LEU   C CG    1 
ATOM   757  C CD1   . LEU   A 1 248  ? 162.347 131.108 154.278 1.00 28.60  ?  248  LEU   C CD1   1 
ATOM   758  C CD2   . LEU   A 1 248  ? 163.808 131.367 156.289 1.00 29.37  ?  248  LEU   C CD2   1 
ATOM   759  N N     . TYR   A 1 249  ? 160.520 134.273 154.011 1.00 19.48  ?  249  TYR   C N     1 
ATOM   760  C CA    . TYR   A 1 249  ? 159.270 134.733 154.614 1.00 18.92  ?  249  TYR   C CA    1 
ATOM   761  C C     . TYR   A 1 249  ? 159.168 136.247 154.605 1.00 23.48  ?  249  TYR   C C     1 
ATOM   762  O O     . TYR   A 1 249  ? 158.645 136.854 155.544 1.00 28.12  ?  249  TYR   C O     1 
ATOM   763  C CB    . TYR   A 1 249  ? 159.141 134.240 156.051 1.00 19.69  ?  249  TYR   C CB    1 
ATOM   764  C CG    . TYR   A 1 249  ? 159.204 132.764 156.219 1.00 19.18  ?  249  TYR   C CG    1 
ATOM   765  C CD1   . TYR   A 1 249  ? 160.009 132.231 157.198 1.00 21.24  ?  249  TYR   C CD1   1 
ATOM   766  C CD2   . TYR   A 1 249  ? 158.468 131.938 155.401 1.00 22.52  ?  249  TYR   C CD2   1 
ATOM   767  C CE1   . TYR   A 1 249  ? 160.086 130.878 157.357 1.00 20.52  ?  249  TYR   C CE1   1 
ATOM   768  C CE2   . TYR   A 1 249  ? 158.542 130.581 155.563 1.00 25.35  ?  249  TYR   C CE2   1 
ATOM   769  C CZ    . TYR   A 1 249  ? 159.350 130.052 156.535 1.00 23.61  ?  249  TYR   C CZ    1 
ATOM   770  O OH    . TYR   A 1 249  ? 159.426 128.699 156.694 1.00 26.92  ?  249  TYR   C OH    1 
ATOM   771  N N     . GLN   A 1 250  ? 159.647 136.858 153.531 1.00 22.07  ?  250  GLN   C N     1 
ATOM   772  C CA    . GLN   A 1 250  ? 159.684 138.308 153.425 1.00 23.38  ?  250  GLN   C CA    1 
ATOM   773  C C     . GLN   A 1 250  ? 158.325 138.941 153.697 1.00 25.26  ?  250  GLN   C C     1 
ATOM   774  O O     . GLN   A 1 250  ? 158.242 140.006 154.308 1.00 24.26  ?  250  GLN   C O     1 
ATOM   775  C CB    . GLN   A 1 250  ? 160.165 138.719 152.031 1.00 25.61  ?  250  GLN   C CB    1 
ATOM   776  C CG    . GLN   A 1 250  ? 160.367 140.213 151.850 1.00 30.80  ?  250  GLN   C CG    1 
ATOM   777  C CD    . GLN   A 1 250  ? 160.663 140.591 150.407 1.00 33.26  ?  250  GLN   C CD    1 
ATOM   778  O OE1   . GLN   A 1 250  ? 159.744 140.901 149.641 1.00 30.49  ?  250  GLN   C OE1   1 
ATOM   779  N NE2   . GLN   A 1 250  ? 161.933 140.563 150.023 1.00 29.57  ?  250  GLN   C NE2   1 
ATOM   780  N N     . ASP   A 1 251  ? 157.265 138.306 153.214 1.00 26.53  ?  251  ASP   C N     1 
ATOM   781  C CA    . ASP   A 1 251  ? 155.926 138.851 153.339 1.00 27.99  ?  251  ASP   C CA    1 
ATOM   782  C C     . ASP   A 1 251  ? 155.048 138.125 154.354 1.00 26.99  ?  251  ASP   C C     1 
ATOM   783  O O     . ASP   A 1 251  ? 153.836 138.356 154.399 1.00 30.14  ?  251  ASP   C O     1 
ATOM   784  C CB    . ASP   A 1 251  ? 155.268 138.830 151.963 1.00 34.16  ?  251  ASP   C CB    1 
ATOM   785  C CG    . ASP   A 1 251  ? 155.282 137.442 151.354 1.00 28.45  ?  251  ASP   C CG    1 
ATOM   786  O OD1   . ASP   A 1 251  ? 155.999 136.605 151.866 1.00 27.78  ?  251  ASP   C OD1   1 
ATOM   787  O OD2   . ASP   A 1 251  ? 154.595 137.225 150.385 1.00 29.43  -1 251  ASP   C OD2   1 
ATOM   788  N N     . ARG   A 1 252  ? 155.636 137.254 155.170 1.00 26.34  ?  252  ARG   C N     1 
ATOM   789  C CA    . ARG   A 1 252  ? 154.820 136.496 156.111 1.00 26.41  ?  252  ARG   C CA    1 
ATOM   790  C C     . ARG   A 1 252  ? 155.005 136.915 157.561 1.00 26.46  ?  252  ARG   C C     1 
ATOM   791  O O     . ARG   A 1 252  ? 154.034 136.978 158.312 1.00 31.36  ?  252  ARG   C O     1 
ATOM   792  C CB    . ARG   A 1 252  ? 155.074 135.006 155.988 1.00 29.48  ?  252  ARG   C CB    1 
ATOM   793  C CG    . ARG   A 1 252  ? 154.183 134.165 156.880 1.00 28.38  ?  252  ARG   C CG    1 
ATOM   794  C CD    . ARG   A 1 252  ? 154.330 132.724 156.624 1.00 31.40  ?  252  ARG   C CD    1 
ATOM   795  N NE    . ARG   A 1 252  ? 153.868 132.371 155.299 1.00 26.14  ?  252  ARG   C NE    1 
ATOM   796  C CZ    . ARG   A 1 252  ? 152.579 132.222 154.946 1.00 26.44  ?  252  ARG   C CZ    1 
ATOM   797  N NH1   . ARG   A 1 252  ? 151.617 132.393 155.829 1.00 28.28  1  252  ARG   C NH1   1 
ATOM   798  N NH2   . ARG   A 1 252  ? 152.283 131.905 153.704 1.00 33.68  ?  252  ARG   C NH2   1 
ATOM   799  N N     . PHE   A 1 253  ? 156.236 137.192 157.975 1.00 24.88  ?  253  PHE   C N     1 
ATOM   800  C CA    . PHE   A 1 253  ? 156.452 137.516 159.384 1.00 26.09  ?  253  PHE   C CA    1 
ATOM   801  C C     . PHE   A 1 253  ? 157.118 138.872 159.582 1.00 29.01  ?  253  PHE   C C     1 
ATOM   802  O O     . PHE   A 1 253  ? 158.103 139.203 158.917 1.00 32.91  ?  253  PHE   C O     1 
ATOM   803  C CB    . PHE   A 1 253  ? 157.303 136.443 160.053 1.00 30.09  ?  253  PHE   C CB    1 
ATOM   804  C CG    . PHE   A 1 253  ? 156.704 135.057 160.026 1.00 25.64  ?  253  PHE   C CG    1 
ATOM   805  C CD1   . PHE   A 1 253  ? 157.266 134.064 159.245 1.00 24.81  ?  253  PHE   C CD1   1 
ATOM   806  C CD2   . PHE   A 1 253  ? 155.591 134.748 160.775 1.00 24.72  ?  253  PHE   C CD2   1 
ATOM   807  C CE1   . PHE   A 1 253  ? 156.734 132.795 159.221 1.00 27.57  ?  253  PHE   C CE1   1 
ATOM   808  C CE2   . PHE   A 1 253  ? 155.053 133.485 160.751 1.00 24.61  ?  253  PHE   C CE2   1 
ATOM   809  C CZ    . PHE   A 1 253  ? 155.627 132.503 159.976 1.00 25.39  ?  253  PHE   C CZ    1 
ATOM   810  N N     . ASP   A 1 254  ? 156.602 139.632 160.546 1.00 26.52  ?  254  ASP   C N     1 
ATOM   811  C CA    . ASP   A 1 254  ? 157.170 140.926 160.897 1.00 26.98  ?  254  ASP   C CA    1 
ATOM   812  C C     . ASP   A 1 254  ? 158.304 140.766 161.886 1.00 26.10  ?  254  ASP   C C     1 
ATOM   813  O O     . ASP   A 1 254  ? 159.270 141.527 161.858 1.00 32.20  ?  254  ASP   C O     1 
ATOM   814  C CB    . ASP   A 1 254  ? 156.117 141.856 161.493 1.00 34.23  ?  254  ASP   C CB    1 
ATOM   815  C CG    . ASP   A 1 254  ? 155.092 142.309 160.501 1.00 40.70  ?  254  ASP   C CG    1 
ATOM   816  O OD1   . ASP   A 1 254  ? 155.449 142.744 159.433 1.00 40.95  ?  254  ASP   C OD1   1 
ATOM   817  O OD2   . ASP   A 1 254  ? 153.937 142.230 160.814 1.00 38.98  -1 254  ASP   C OD2   1 
ATOM   818  N N     . TYR   A 1 255  ? 158.185 139.773 162.758 1.00 24.00  ?  255  TYR   C N     1 
ATOM   819  C CA    . TYR   A 1 255  ? 159.229 139.522 163.740 1.00 25.57  ?  255  TYR   C CA    1 
ATOM   820  C C     . TYR   A 1 255  ? 159.541 138.046 163.893 1.00 27.94  ?  255  TYR   C C     1 
ATOM   821  O O     . TYR   A 1 255  ? 158.630 137.219 163.993 1.00 29.53  ?  255  TYR   C O     1 
ATOM   822  C CB    . TYR   A 1 255  ? 158.826 140.065 165.104 1.00 25.29  ?  255  TYR   C CB    1 
ATOM   823  C CG    . TYR   A 1 255  ? 158.567 141.520 165.136 1.00 24.59  ?  255  TYR   C CG    1 
ATOM   824  C CD1   . TYR   A 1 255  ? 157.303 142.004 164.879 1.00 28.26  ?  255  TYR   C CD1   1 
ATOM   825  C CD2   . TYR   A 1 255  ? 159.591 142.379 165.429 1.00 29.04  ?  255  TYR   C CD2   1 
ATOM   826  C CE1   . TYR   A 1 255  ? 157.073 143.346 164.913 1.00 35.96  ?  255  TYR   C CE1   1 
ATOM   827  C CE2   . TYR   A 1 255  ? 159.365 143.721 165.464 1.00 33.21  ?  255  TYR   C CE2   1 
ATOM   828  C CZ    . TYR   A 1 255  ? 158.114 144.207 165.209 1.00 37.91  ?  255  TYR   C CZ    1 
ATOM   829  O OH    . TYR   A 1 255  ? 157.892 145.556 165.248 1.00 44.38  ?  255  TYR   C OH    1 
ATOM   830  N N     . LEU   A 1 256  ? 160.821 137.723 164.002 1.00 25.66  ?  256  LEU   C N     1 
ATOM   831  C CA    . LEU   A 1 256  ? 161.243 136.389 164.401 1.00 21.60  ?  256  LEU   C CA    1 
ATOM   832  C C     . LEU   A 1 256  ? 161.925 136.474 165.749 1.00 23.88  ?  256  LEU   C C     1 
ATOM   833  O O     . LEU   A 1 256  ? 162.835 137.282 165.934 1.00 28.40  ?  256  LEU   C O     1 
ATOM   834  C CB    . LEU   A 1 256  ? 162.188 135.766 163.372 1.00 19.70  ?  256  LEU   C CB    1 
ATOM   835  C CG    . LEU   A 1 256  ? 161.565 134.838 162.340 1.00 23.35  ?  256  LEU   C CG    1 
ATOM   836  C CD1   . LEU   A 1 256  ? 160.597 135.602 161.476 1.00 25.19  ?  256  LEU   C CD1   1 
ATOM   837  C CD2   . LEU   A 1 256  ? 162.684 134.227 161.499 1.00 28.26  ?  256  LEU   C CD2   1 
ATOM   838  N N     . PHE   A 1 257  ? 161.496 135.653 166.692 1.00 23.54  ?  257  PHE   C N     1 
ATOM   839  C CA    . PHE   A 1 257  ? 162.062 135.710 168.031 1.00 22.22  ?  257  PHE   C CA    1 
ATOM   840  C C     . PHE   A 1 257  ? 162.819 134.451 168.381 1.00 25.44  ?  257  PHE   C C     1 
ATOM   841  O O     . PHE   A 1 257  ? 162.226 133.381 168.535 1.00 27.15  ?  257  PHE   C O     1 
ATOM   842  C CB    . PHE   A 1 257  ? 160.971 135.943 169.068 1.00 23.69  ?  257  PHE   C CB    1 
ATOM   843  C CG    . PHE   A 1 257  ? 160.263 137.239 168.891 1.00 25.32  ?  257  PHE   C CG    1 
ATOM   844  C CD1   . PHE   A 1 257  ? 159.011 137.281 168.310 1.00 28.99  ?  257  PHE   C CD1   1 
ATOM   845  C CD2   . PHE   A 1 257  ? 160.849 138.422 169.287 1.00 28.90  ?  257  PHE   C CD2   1 
ATOM   846  C CE1   . PHE   A 1 257  ? 158.359 138.481 168.133 1.00 29.92  ?  257  PHE   C CE1   1 
ATOM   847  C CE2   . PHE   A 1 257  ? 160.203 139.624 169.109 1.00 33.87  ?  257  PHE   C CE2   1 
ATOM   848  C CZ    . PHE   A 1 257  ? 158.956 139.654 168.530 1.00 33.68  ?  257  PHE   C CZ    1 
ATOM   849  N N     . TYR   A 1 258  ? 164.128 134.574 168.520 1.00 24.99  ?  258  TYR   C N     1 
ATOM   850  C CA    . TYR   A 1 258  ? 164.935 133.412 168.842 1.00 24.43  ?  258  TYR   C CA    1 
ATOM   851  C C     . TYR   A 1 258  ? 164.961 133.169 170.337 1.00 27.87  ?  258  TYR   C C     1 
ATOM   852  O O     . TYR   A 1 258  ? 165.341 134.043 171.119 1.00 35.20  ?  258  TYR   C O     1 
ATOM   853  C CB    . TYR   A 1 258  ? 166.356 133.587 168.320 1.00 27.20  ?  258  TYR   C CB    1 
ATOM   854  C CG    . TYR   A 1 258  ? 167.250 132.437 168.594 1.00 27.26  ?  258  TYR   C CG    1 
ATOM   855  C CD1   . TYR   A 1 258  ? 167.183 131.318 167.793 1.00 24.78  ?  258  TYR   C CD1   1 
ATOM   856  C CD2   . TYR   A 1 258  ? 168.141 132.490 169.642 1.00 33.50  ?  258  TYR   C CD2   1 
ATOM   857  C CE1   . TYR   A 1 258  ? 168.009 130.250 168.038 1.00 23.86  ?  258  TYR   C CE1   1 
ATOM   858  C CE2   . TYR   A 1 258  ? 168.967 131.422 169.886 1.00 34.65  ?  258  TYR   C CE2   1 
ATOM   859  C CZ    . TYR   A 1 258  ? 168.903 130.308 169.096 1.00 28.97  ?  258  TYR   C CZ    1 
ATOM   860  O OH    . TYR   A 1 258  ? 169.728 129.249 169.362 1.00 34.37  ?  258  TYR   C OH    1 
ATOM   861  N N     . ILE   A 1 259  ? 164.575 131.968 170.728 1.00 25.00  ?  259  ILE   C N     1 
ATOM   862  C CA    . ILE   A 1 259  ? 164.605 131.566 172.118 1.00 23.71  ?  259  ILE   C CA    1 
ATOM   863  C C     . ILE   A 1 259  ? 165.651 130.490 172.296 1.00 28.85  ?  259  ILE   C C     1 
ATOM   864  O O     . ILE   A 1 259  ? 165.560 129.413 171.703 1.00 34.15  ?  259  ILE   C O     1 
ATOM   865  C CB    . ILE   A 1 259  ? 163.239 131.039 172.577 1.00 23.96  ?  259  ILE   C CB    1 
ATOM   866  C CG1   . ILE   A 1 259  ? 162.181 132.140 172.435 1.00 27.97  ?  259  ILE   C CG1   1 
ATOM   867  C CG2   . ILE   A 1 259  ? 163.339 130.542 174.013 1.00 31.43  ?  259  ILE   C CG2   1 
ATOM   868  C CD1   . ILE   A 1 259  ? 160.754 131.646 172.585 1.00 33.87  ?  259  ILE   C CD1   1 
ATOM   869  N N     . HIS   A 1 260  ? 166.650 130.773 173.110 1.00 32.67  ?  260  HIS   C N     1 
ATOM   870  C CA    . HIS   A 1 260  ? 167.702 129.800 173.314 1.00 38.17  ?  260  HIS   C CA    1 
ATOM   871  C C     . HIS   A 1 260  ? 167.327 128.951 174.519 1.00 41.77  ?  260  HIS   C C     1 
ATOM   872  O O     . HIS   A 1 260  ? 167.271 129.450 175.644 1.00 44.75  ?  260  HIS   C O     1 
ATOM   873  C CB    . HIS   A 1 260  ? 169.051 130.495 173.517 1.00 43.47  ?  260  HIS   C CB    1 
ATOM   874  C CG    . HIS   A 1 260  ? 170.235 129.606 173.300 1.00 45.71  ?  260  HIS   C CG    1 
ATOM   875  N ND1   . HIS   A 1 260  ? 171.519 129.981 173.640 1.00 50.74  ?  260  HIS   C ND1   1 
ATOM   876  C CD2   . HIS   A 1 260  ? 170.335 128.369 172.762 1.00 43.04  ?  260  HIS   C CD2   1 
ATOM   877  C CE1   . HIS   A 1 260  ? 172.355 129.010 173.325 1.00 56.37  ?  260  HIS   C CE1   1 
ATOM   878  N NE2   . HIS   A 1 260  ? 171.660 128.023 172.790 1.00 49.29  ?  260  HIS   C NE2   1 
ATOM   879  N N     . CYS   A 1 261  ? 167.048 127.673 174.285 1.00 35.82  ?  261  CYS   C N     1 
ATOM   880  C CA    . CYS   A 1 261  ? 166.544 126.795 175.336 1.00 35.32  ?  261  CYS   C CA    1 
ATOM   881  C C     . CYS   A 1 261  ? 167.641 126.456 176.332 1.00 39.47  ?  261  CYS   C C     1 
ATOM   882  O O     . CYS   A 1 261  ? 167.392 125.884 177.391 1.00 42.83  ?  261  CYS   C O     1 
ATOM   883  C CB    . CYS   A 1 261  ? 165.977 125.521 174.724 1.00 38.01  ?  261  CYS   C CB    1 
ATOM   884  S SG    . CYS   A 1 261  ? 164.496 125.787 173.716 1.00 41.88  ?  261  CYS   C SG    1 
ATOM   885  N N     . ARG   A 1 262  ? 168.856 126.852 175.988 1.00 42.17  ?  262  ARG   C N     1 
ATOM   886  C CA    . ARG   A 1 262  ? 170.024 126.660 176.826 1.00 46.84  ?  262  ARG   C CA    1 
ATOM   887  C C     . ARG   A 1 262  ? 170.143 127.791 177.843 1.00 48.80  ?  262  ARG   C C     1 
ATOM   888  O O     . ARG   A 1 262  ? 170.869 127.678 178.830 1.00 54.21  ?  262  ARG   C O     1 
ATOM   889  C CB    . ARG   A 1 262  ? 171.273 126.629 175.963 1.00 47.66  ?  262  ARG   C CB    1 
ATOM   890  C CG    . ARG   A 1 262  ? 172.549 126.238 176.658 1.00 53.69  ?  262  ARG   C CG    1 
ATOM   891  C CD    . ARG   A 1 262  ? 173.701 126.248 175.715 1.00 57.25  ?  262  ARG   C CD    1 
ATOM   892  N NE    . ARG   A 1 262  ? 173.569 125.235 174.669 1.00 54.92  ?  262  ARG   C NE    1 
ATOM   893  C CZ    . ARG   A 1 262  ? 174.368 125.140 173.587 1.00 57.84  ?  262  ARG   C CZ    1 
ATOM   894  N NH1   . ARG   A 1 262  ? 175.355 125.997 173.414 1.00 61.93  1  262  ARG   C NH1   1 
ATOM   895  N NH2   . ARG   A 1 262  ? 174.162 124.183 172.696 1.00 54.88  ?  262  ARG   C NH2   1 
ATOM   896  N N     . GLU   A 1 263  ? 169.442 128.894 177.584 1.00 45.91  ?  263  GLU   C N     1 
ATOM   897  C CA    . GLU   A 1 263  ? 169.518 130.071 178.438 1.00 47.51  ?  263  GLU   C CA    1 
ATOM   898  C C     . GLU   A 1 263  ? 168.284 130.209 179.316 1.00 45.95  ?  263  GLU   C C     1 
ATOM   899  O O     . GLU   A 1 263  ? 168.358 130.742 180.423 1.00 50.51  ?  263  GLU   C O     1 
ATOM   900  C CB    . GLU   A 1 263  ? 169.675 131.335 177.590 1.00 50.90  ?  263  GLU   C CB    1 
ATOM   901  C CG    . GLU   A 1 263  ? 170.965 131.403 176.795 1.00 55.94  ?  263  GLU   C CG    1 
ATOM   902  C CD    . GLU   A 1 263  ? 171.039 132.620 175.910 1.00 61.55  ?  263  GLU   C CD    1 
ATOM   903  O OE1   . GLU   A 1 263  ? 170.409 133.602 176.227 1.00 62.44  ?  263  GLU   C OE1   1 
ATOM   904  O OE2   . GLU   A 1 263  ? 171.715 132.562 174.908 1.00 58.06  -1 263  GLU   C OE2   1 
ATOM   905  N N     . VAL   A 1 264  ? 167.145 129.743 178.820 1.00 43.58  ?  264  VAL   C N     1 
ATOM   906  C CA    . VAL   A 1 264  ? 165.898 129.910 179.555 1.00 44.12  ?  264  VAL   C CA    1 
ATOM   907  C C     . VAL   A 1 264  ? 165.612 128.731 180.466 1.00 44.47  ?  264  VAL   C C     1 
ATOM   908  O O     . VAL   A 1 264  ? 165.261 127.645 180.009 1.00 46.54  ?  264  VAL   C O     1 
ATOM   909  C CB    . VAL   A 1 264  ? 164.722 130.087 178.580 1.00 40.07  ?  264  VAL   C CB    1 
ATOM   910  C CG1   . VAL   A 1 264  ? 163.414 130.224 179.348 1.00 39.52  ?  264  VAL   C CG1   1 
ATOM   911  C CG2   . VAL   A 1 264  ? 164.964 131.312 177.728 1.00 46.34  ?  264  VAL   C CG2   1 
ATOM   912  N N     . SER   A 1 265  ? 165.731 128.963 181.765 1.00 44.24  ?  265  SER   C N     1 
ATOM   913  C CA    . SER   A 1 265  ? 165.472 127.934 182.758 1.00 44.59  ?  265  SER   C CA    1 
ATOM   914  C C     . SER   A 1 265  ? 163.977 127.832 183.003 1.00 49.17  ?  265  SER   C C     1 
ATOM   915  O O     . SER   A 1 265  ? 163.210 128.700 182.582 1.00 53.63  ?  265  SER   C O     1 
ATOM   916  C CB    . SER   A 1 265  ? 166.196 128.252 184.049 1.00 46.56  ?  265  SER   C CB    1 
ATOM   917  O OG    . SER   A 1 265  ? 165.651 129.385 184.664 1.00 52.80  ?  265  SER   C OG    1 
ATOM   918  N N     . LEU   A 1 266  ? 163.557 126.778 183.688 1.00 49.79  ?  266  LEU   C N     1 
ATOM   919  C CA    . LEU   A 1 266  ? 162.141 126.590 183.967 1.00 52.79  ?  266  LEU   C CA    1 
ATOM   920  C C     . LEU   A 1 266  ? 161.731 127.123 185.344 1.00 56.69  ?  266  LEU   C C     1 
ATOM   921  O O     . LEU   A 1 266  ? 160.575 127.494 185.554 1.00 57.50  ?  266  LEU   C O     1 
ATOM   922  C CB    . LEU   A 1 266  ? 161.808 125.097 183.862 1.00 53.48  ?  266  LEU   C CB    1 
ATOM   923  C CG    . LEU   A 1 266  ? 162.116 124.420 182.485 1.00 57.64  ?  266  LEU   C CG    1 
ATOM   924  C CD1   . LEU   A 1 266  ? 161.874 122.921 182.601 1.00 59.21  ?  266  LEU   C CD1   1 
ATOM   925  C CD2   . LEU   A 1 266  ? 161.227 125.014 181.390 1.00 53.39  ?  266  LEU   C CD2   1 
ATOM   926  N N     . VAL   A 1 267  ? 162.670 127.149 186.282 1.00 55.89  ?  267  VAL   C N     1 
ATOM   927  C CA    . VAL   A 1 267  ? 162.362 127.512 187.668 1.00 56.22  ?  267  VAL   C CA    1 
ATOM   928  C C     . VAL   A 1 267  ? 161.996 128.983 187.868 1.00 58.26  ?  267  VAL   C C     1 
ATOM   929  O O     . VAL   A 1 267  ? 161.093 129.300 188.642 1.00 60.95  ?  267  VAL   C O     1 
ATOM   930  C CB    . VAL   A 1 267  ? 163.552 127.152 188.580 1.00 59.79  ?  267  VAL   C CB    1 
ATOM   931  C CG1   . VAL   A 1 267  ? 163.318 127.675 190.006 1.00 58.08  ?  267  VAL   C CG1   1 
ATOM   932  C CG2   . VAL   A 1 267  ? 163.712 125.638 188.597 1.00 64.75  ?  267  VAL   C CG2   1 
ATOM   933  N N     . THR   A 1 268  ? 162.734 129.880 187.223 1.00 58.00  ?  268  THR   C N     1 
ATOM   934  C CA    . THR   A 1 268  ? 162.543 131.317 187.403 1.00 59.20  ?  268  THR   C CA    1 
ATOM   935  C C     . THR   A 1 268  ? 161.189 131.801 186.888 1.00 59.32  ?  268  THR   C C     1 
ATOM   936  O O     . THR   A 1 268  ? 160.798 131.507 185.761 1.00 57.49  ?  268  THR   C O     1 
ATOM   937  C CB    . THR   A 1 268  ? 163.667 132.107 186.697 1.00 58.87  ?  268  THR   C CB    1 
ATOM   938  O OG1   . THR   A 1 268  ? 164.934 131.735 187.257 1.00 58.88  ?  268  THR   C OG1   1 
ATOM   939  C CG2   . THR   A 1 268  ? 163.464 133.604 186.871 1.00 58.26  ?  268  THR   C CG2   1 
ATOM   940  N N     . GLN   A 1 269  ? 160.498 132.579 187.715 1.00 58.34  ?  269  GLN   C N     1 
ATOM   941  C CA    . GLN   A 1 269  ? 159.216 133.163 187.337 1.00 57.47  ?  269  GLN   C CA    1 
ATOM   942  C C     . GLN   A 1 269  ? 159.426 134.436 186.526 1.00 56.62  ?  269  GLN   C C     1 
ATOM   943  O O     . GLN   A 1 269  ? 160.190 135.313 186.929 1.00 56.08  ?  269  GLN   C O     1 
ATOM   944  C CB    . GLN   A 1 269  ? 158.381 133.470 188.584 1.00 59.43  ?  269  GLN   C CB    1 
ATOM   945  C CG    . GLN   A 1 269  ? 157.018 134.039 188.280 1.00 62.15  ?  269  GLN   C CG    1 
ATOM   946  C CD    . GLN   A 1 269  ? 156.177 134.270 189.505 1.00 66.07  ?  269  GLN   C CD    1 
ATOM   947  O OE1   . GLN   A 1 269  ? 156.668 134.185 190.635 1.00 71.33  ?  269  GLN   C OE1   1 
ATOM   948  N NE2   . GLN   A 1 269  ? 154.893 134.566 189.301 1.00 62.74  ?  269  GLN   C NE2   1 
ATOM   949  N N     . ARG   A 1 270  ? 158.756 134.531 185.383 1.00 55.37  ?  270  ARG   C N     1 
ATOM   950  C CA    . ARG   A 1 270  ? 158.901 135.700 184.524 1.00 49.74  ?  270  ARG   C CA    1 
ATOM   951  C C     . ARG   A 1 270  ? 157.728 135.881 183.566 1.00 50.32  ?  270  ARG   C C     1 
ATOM   952  O O     . ARG   A 1 270  ? 157.034 134.922 183.221 1.00 52.50  ?  270  ARG   C O     1 
ATOM   953  C CB    . ARG   A 1 270  ? 160.205 135.606 183.743 1.00 49.24  ?  270  ARG   C CB    1 
ATOM   954  C CG    . ARG   A 1 270  ? 160.365 134.335 182.915 1.00 54.12  ?  270  ARG   C CG    1 
ATOM   955  C CD    . ARG   A 1 270  ? 161.787 134.108 182.505 1.00 54.85  ?  270  ARG   C CD    1 
ATOM   956  N NE    . ARG   A 1 270  ? 162.240 135.059 181.497 1.00 52.43  ?  270  ARG   C NE    1 
ATOM   957  C CZ    . ARG   A 1 270  ? 162.075 134.905 180.165 1.00 51.45  ?  270  ARG   C CZ    1 
ATOM   958  N NH1   . ARG   A 1 270  ? 161.469 133.844 179.686 1.00 48.35  1  270  ARG   C NH1   1 
ATOM   959  N NH2   . ARG   A 1 270  ? 162.518 135.822 179.329 1.00 48.56  ?  270  ARG   C NH2   1 
ATOM   960  N N     . SER   A 1 271  ? 157.533 137.117 183.120 1.00 49.40  ?  271  SER   C N     1 
ATOM   961  C CA    . SER   A 1 271  ? 156.532 137.460 182.116 1.00 52.46  ?  271  SER   C CA    1 
ATOM   962  C C     . SER   A 1 271  ? 157.060 137.128 180.743 1.00 47.44  ?  271  SER   C C     1 
ATOM   963  O O     . SER   A 1 271  ? 158.210 136.701 180.608 1.00 48.14  ?  271  SER   C O     1 
ATOM   964  C CB    . SER   A 1 271  ? 156.185 138.932 182.200 1.00 59.37  ?  271  SER   C CB    1 
ATOM   965  O OG    . SER   A 1 271  ? 157.275 139.725 181.812 1.00 60.28  ?  271  SER   C OG    1 
ATOM   966  N N     . LEU   A 1 272  ? 156.248 137.318 179.710 1.00 45.15  ?  272  LEU   C N     1 
ATOM   967  C CA    . LEU   A 1 272  ? 156.729 137.007 178.378 1.00 41.55  ?  272  LEU   C CA    1 
ATOM   968  C C     . LEU   A 1 272  ? 157.622 138.131 177.881 1.00 40.81  ?  272  LEU   C C     1 
ATOM   969  O O     . LEU   A 1 272  ? 157.278 138.875 176.963 1.00 38.00  ?  272  LEU   C O     1 
ATOM   970  C CB    . LEU   A 1 272  ? 155.565 136.826 177.409 1.00 35.00  ?  272  LEU   C CB    1 
ATOM   971  C CG    . LEU   A 1 272  ? 155.929 136.283 176.015 1.00 35.67  ?  272  LEU   C CG    1 
ATOM   972  C CD1   . LEU   A 1 272  ? 156.430 134.845 176.120 1.00 43.79  ?  272  LEU   C CD1   1 
ATOM   973  C CD2   . LEU   A 1 272  ? 154.724 136.372 175.126 1.00 31.13  ?  272  LEU   C CD2   1 
ATOM   974  N N     . GLY   A 1 273  ? 158.792 138.225 178.498 1.00 43.65  ?  273  GLY   C N     1 
ATOM   975  C CA    . GLY   A 1 273  ? 159.779 139.243 178.193 1.00 40.59  ?  273  GLY   C CA    1 
ATOM   976  C C     . GLY   A 1 273  ? 160.749 138.736 177.145 1.00 41.73  ?  273  GLY   C C     1 
ATOM   977  O O     . GLY   A 1 273  ? 161.734 139.396 176.829 1.00 41.45  ?  273  GLY   C O     1 
ATOM   978  N N     . ASP   A 1 274  ? 160.458 137.561 176.596 1.00 42.14  ?  274  ASP   C N     1 
ATOM   979  C CA    . ASP   A 1 274  ? 161.298 136.949 175.575 1.00 42.41  ?  274  ASP   C CA    1 
ATOM   980  C C     . ASP   A 1 274  ? 161.403 137.874 174.376 1.00 41.97  ?  274  ASP   C C     1 
ATOM   981  O O     . ASP   A 1 274  ? 162.431 137.932 173.700 1.00 41.95  ?  274  ASP   C O     1 
ATOM   982  C CB    . ASP   A 1 274  ? 160.707 135.611 175.115 1.00 40.22  ?  274  ASP   C CB    1 
ATOM   983  C CG    . ASP   A 1 274  ? 160.769 134.520 176.159 1.00 38.97  ?  274  ASP   C CG    1 
ATOM   984  O OD1   . ASP   A 1 274  ? 161.513 134.650 177.099 1.00 39.58  ?  274  ASP   C OD1   1 
ATOM   985  O OD2   . ASP   A 1 274  ? 160.049 133.567 176.022 1.00 39.61  -1 274  ASP   C OD2   1 
ATOM   986  N N     . LEU   A 1 275  ? 160.330 138.616 174.129 1.00 37.02  ?  275  LEU   C N     1 
ATOM   987  C CA    . LEU   A 1 275  ? 160.246 139.511 172.989 1.00 34.97  ?  275  LEU   C CA    1 
ATOM   988  C C     . LEU   A 1 275  ? 161.133 140.730 173.189 1.00 39.68  ?  275  LEU   C C     1 
ATOM   989  O O     . LEU   A 1 275  ? 161.398 141.476 172.247 1.00 42.22  ?  275  LEU   C O     1 
ATOM   990  C CB    . LEU   A 1 275  ? 158.798 139.950 172.786 1.00 35.54  ?  275  LEU   C CB    1 
ATOM   991  C CG    . LEU   A 1 275  ? 157.900 138.986 171.991 1.00 41.45  ?  275  LEU   C CG    1 
ATOM   992  C CD1   . LEU   A 1 275  ? 157.726 137.687 172.750 1.00 37.73  ?  275  LEU   C CD1   1 
ATOM   993  C CD2   . LEU   A 1 275  ? 156.569 139.648 171.760 1.00 58.68  ?  275  LEU   C CD2   1 
ATOM   994  N N     . ILE   A 1 276  ? 161.575 140.938 174.425 1.00 39.11  ?  276  ILE   C N     1 
ATOM   995  C CA    . ILE   A 1 276  ? 162.479 142.026 174.749 1.00 40.06  ?  276  ILE   C CA    1 
ATOM   996  C C     . ILE   A 1 276  ? 163.896 141.481 174.883 1.00 42.52  ?  276  ILE   C C     1 
ATOM   997  O O     . ILE   A 1 276  ? 164.853 142.059 174.374 1.00 43.01  ?  276  ILE   C O     1 
ATOM   998  C CB    . ILE   A 1 276  ? 162.059 142.734 176.048 1.00 40.91  ?  276  ILE   C CB    1 
ATOM   999  C CG1   . ILE   A 1 276  ? 160.653 143.342 175.865 1.00 42.71  ?  276  ILE   C CG1   1 
ATOM   1000 C CG2   . ILE   A 1 276  ? 163.086 143.823 176.398 1.00 42.29  ?  276  ILE   C CG2   1 
ATOM   1001 C CD1   . ILE   A 1 276  ? 160.010 143.824 177.143 1.00 44.50  ?  276  ILE   C CD1   1 
ATOM   1002 N N     . MET   A 1 277  ? 164.029 140.361 175.579 1.00 41.52  ?  277  MET   C N     1 
ATOM   1003 C CA    . MET   A 1 277  ? 165.326 139.754 175.845 1.00 44.17  ?  277  MET   C CA    1 
ATOM   1004 C C     . MET   A 1 277  ? 166.098 139.454 174.564 1.00 44.20  ?  277  MET   C C     1 
ATOM   1005 O O     . MET   A 1 277  ? 167.317 139.613 174.518 1.00 44.93  ?  277  MET   C O     1 
ATOM   1006 C CB    . MET   A 1 277  ? 165.135 138.477 176.655 1.00 48.90  ?  277  MET   C CB    1 
ATOM   1007 C CG    . MET   A 1 277  ? 166.417 137.720 176.987 1.00 56.36  ?  277  MET   C CG    1 
ATOM   1008 S SD    . MET   A 1 277  ? 166.102 136.193 177.910 1.00 70.12  ?  277  MET   C SD    1 
ATOM   1009 C CE    . MET   A 1 277  ? 165.360 135.141 176.655 1.00 49.31  ?  277  MET   C CE    1 
ATOM   1010 N N     . SER   A 1 278  ? 165.390 139.012 173.528 1.00 41.99  ?  278  SER   C N     1 
ATOM   1011 C CA    . SER   A 1 278  ? 166.027 138.644 172.269 1.00 42.61  ?  278  SER   C CA    1 
ATOM   1012 C C     . SER   A 1 278  ? 165.978 139.753 171.221 1.00 41.52  ?  278  SER   C C     1 
ATOM   1013 O O     . SER   A 1 278  ? 166.284 139.507 170.052 1.00 40.50  ?  278  SER   C O     1 
ATOM   1014 C CB    . SER   A 1 278  ? 165.397 137.378 171.708 1.00 41.34  ?  278  SER   C CB    1 
ATOM   1015 O OG    . SER   A 1 278  ? 165.652 136.279 172.529 1.00 45.19  ?  278  SER   C OG    1 
ATOM   1016 N N     . CYS   A 1 279  ? 165.574 140.960 171.618 1.00 40.06  ?  279  CYS   C N     1 
ATOM   1017 C CA    . CYS   A 1 279  ? 165.490 142.066 170.674 1.00 36.83  ?  279  CYS   C CA    1 
ATOM   1018 C C     . CYS   A 1 279  ? 166.693 142.982 170.798 1.00 40.25  ?  279  CYS   C C     1 
ATOM   1019 O O     . CYS   A 1 279  ? 167.610 142.735 171.580 1.00 42.81  ?  279  CYS   C O     1 
ATOM   1020 C CB    . CYS   A 1 279  ? 164.230 142.908 170.877 1.00 35.95  ?  279  CYS   C CB    1 
ATOM   1021 S SG    . CYS   A 1 279  ? 164.331 144.096 172.234 1.00 45.32  ?  279  CYS   C SG    1 
ATOM   1022 N N     . CYS   A 1 280  ? 166.673 144.050 170.015 1.00 40.15  ?  280  CYS   C N     1 
ATOM   1023 C CA    . CYS   A 1 280  ? 167.736 145.036 170.015 1.00 43.25  ?  280  CYS   C CA    1 
ATOM   1024 C C     . CYS   A 1 280  ? 167.952 145.557 171.442 1.00 44.33  ?  280  CYS   C C     1 
ATOM   1025 O O     . CYS   A 1 280  ? 167.089 145.361 172.294 1.00 43.93  ?  280  CYS   C O     1 
ATOM   1026 C CB    . CYS   A 1 280  ? 167.338 146.172 169.082 1.00 47.25  ?  280  CYS   C CB    1 
ATOM   1027 S SG    . CYS   A 1 280  ? 166.084 147.258 169.778 1.00 46.17  ?  280  CYS   C SG    1 
ATOM   1028 N N     . PRO   A 1 281  ? 169.069 146.254 171.718 1.00 48.35  ?  281  PRO   C N     1 
ATOM   1029 C CA    . PRO   A 1 281  ? 169.475 146.767 173.020 1.00 51.82  ?  281  PRO   C CA    1 
ATOM   1030 C C     . PRO   A 1 281  ? 168.450 147.682 173.679 1.00 52.12  ?  281  PRO   C C     1 
ATOM   1031 O O     . PRO   A 1 281  ? 168.496 147.884 174.891 1.00 50.87  ?  281  PRO   C O     1 
ATOM   1032 C CB    . PRO   A 1 281  ? 170.759 147.537 172.685 1.00 50.01  ?  281  PRO   C CB    1 
ATOM   1033 C CG    . PRO   A 1 281  ? 171.278 146.886 171.434 1.00 52.03  ?  281  PRO   C CG    1 
ATOM   1034 C CD    . PRO   A 1 281  ? 170.045 146.541 170.649 1.00 48.02  ?  281  PRO   C CD    1 
ATOM   1035 N N     . ASP   A 1 282  ? 167.545 148.249 172.892 1.00 47.70  ?  282  ASP   C N     1 
ATOM   1036 C CA    . ASP   A 1 282  ? 166.535 149.157 173.423 1.00 49.91  ?  282  ASP   C CA    1 
ATOM   1037 C C     . ASP   A 1 282  ? 165.565 148.393 174.327 1.00 46.99  ?  282  ASP   C C     1 
ATOM   1038 O O     . ASP   A 1 282  ? 164.822 147.543 173.837 1.00 47.70  ?  282  ASP   C O     1 
ATOM   1039 C CB    . ASP   A 1 282  ? 165.761 149.818 172.283 1.00 53.91  ?  282  ASP   C CB    1 
ATOM   1040 C CG    . ASP   A 1 282  ? 164.784 150.895 172.751 1.00 60.93  ?  282  ASP   C CG    1 
ATOM   1041 O OD1   . ASP   A 1 282  ? 164.308 150.811 173.865 1.00 55.44  ?  282  ASP   C OD1   1 
ATOM   1042 O OD2   . ASP   A 1 282  ? 164.522 151.795 171.988 1.00 57.78  -1 282  ASP   C OD2   1 
ATOM   1043 N N     . PRO   A 1 283  ? 165.541 148.686 175.636 1.00 45.36  ?  283  PRO   C N     1 
ATOM   1044 C CA    . PRO   A 1 283  ? 164.814 147.973 176.663 1.00 45.32  ?  283  PRO   C CA    1 
ATOM   1045 C C     . PRO   A 1 283  ? 163.313 148.226 176.619 1.00 46.68  ?  283  PRO   C C     1 
ATOM   1046 O O     . PRO   A 1 283  ? 162.560 147.593 177.356 1.00 50.22  ?  283  PRO   C O     1 
ATOM   1047 C CB    . PRO   A 1 283  ? 165.452 148.518 177.947 1.00 47.46  ?  283  PRO   C CB    1 
ATOM   1048 C CG    . PRO   A 1 283  ? 165.885 149.918 177.594 1.00 50.69  ?  283  PRO   C CG    1 
ATOM   1049 C CD    . PRO   A 1 283  ? 166.302 149.849 176.138 1.00 49.41  ?  283  PRO   C CD    1 
ATOM   1050 N N     . ASN   A 1 284  ? 162.874 149.159 175.775 1.00 42.46  ?  284  ASN   C N     1 
ATOM   1051 C CA    . ASN   A 1 284  ? 161.456 149.502 175.725 1.00 43.95  ?  284  ASN   C CA    1 
ATOM   1052 C C     . ASN   A 1 284  ? 160.889 149.553 174.306 1.00 43.63  ?  284  ASN   C C     1 
ATOM   1053 O O     . ASN   A 1 284  ? 160.503 150.625 173.838 1.00 47.92  ?  284  ASN   C O     1 
ATOM   1054 C CB    . ASN   A 1 284  ? 161.207 150.824 176.424 1.00 45.67  ?  284  ASN   C CB    1 
ATOM   1055 C CG    . ASN   A 1 284  ? 161.521 150.765 177.888 1.00 52.50  ?  284  ASN   C CG    1 
ATOM   1056 O OD1   . ASN   A 1 284  ? 160.785 150.145 178.663 1.00 49.73  ?  284  ASN   C OD1   1 
ATOM   1057 N ND2   . ASN   A 1 284  ? 162.590 151.398 178.287 1.00 54.57  ?  284  ASN   C ND2   1 
ATOM   1058 N N     . PRO   A 1 285  ? 160.807 148.408 173.618 1.00 38.92  ?  285  PRO   C N     1 
ATOM   1059 C CA    . PRO   A 1 285  ? 160.224 148.230 172.307 1.00 39.21  ?  285  PRO   C CA    1 
ATOM   1060 C C     . PRO   A 1 285  ? 158.707 148.374 172.400 1.00 43.11  ?  285  PRO   C C     1 
ATOM   1061 O O     . PRO   A 1 285  ? 158.132 148.187 173.474 1.00 45.85  ?  285  PRO   C O     1 
ATOM   1062 C CB    . PRO   A 1 285  ? 160.646 146.803 171.955 1.00 38.35  ?  285  PRO   C CB    1 
ATOM   1063 C CG    . PRO   A 1 285  ? 160.802 146.128 173.277 1.00 42.62  ?  285  PRO   C CG    1 
ATOM   1064 C CD    . PRO   A 1 285  ? 161.352 147.181 174.194 1.00 41.80  ?  285  PRO   C CD    1 
ATOM   1065 N N     . PRO   A 1 286  ? 158.037 148.650 171.284 1.00 46.72  ?  286  PRO   C N     1 
ATOM   1066 C CA    . PRO   A 1 286  ? 156.606 148.840 171.156 1.00 52.17  ?  286  PRO   C CA    1 
ATOM   1067 C C     . PRO   A 1 286  ? 155.840 147.525 171.219 1.00 48.88  ?  286  PRO   C C     1 
ATOM   1068 O O     . PRO   A 1 286  ? 155.209 147.110 170.248 1.00 49.03  ?  286  PRO   C O     1 
ATOM   1069 C CB    . PRO   A 1 286  ? 156.507 149.508 169.780 1.00 49.48  ?  286  PRO   C CB    1 
ATOM   1070 C CG    . PRO   A 1 286  ? 157.668 148.946 169.008 1.00 47.68  ?  286  PRO   C CG    1 
ATOM   1071 C CD    . PRO   A 1 286  ? 158.781 148.813 170.026 1.00 47.37  ?  286  PRO   C CD    1 
ATOM   1072 N N     . ILE   A 1 287  ? 155.883 146.890 172.384 1.00 42.48  ?  287  ILE   C N     1 
ATOM   1073 C CA    . ILE   A 1 287  ? 155.260 145.588 172.587 1.00 46.85  ?  287  ILE   C CA    1 
ATOM   1074 C C     . ILE   A 1 287  ? 153.756 145.650 172.360 1.00 51.59  ?  287  ILE   C C     1 
ATOM   1075 O O     . ILE   A 1 287  ? 153.157 144.700 171.862 1.00 55.26  ?  287  ILE   C O     1 
ATOM   1076 C CB    . ILE   A 1 287  ? 155.536 145.038 174.002 1.00 50.21  ?  287  ILE   C CB    1 
ATOM   1077 C CG1   . ILE   A 1 287  ? 157.060 144.820 174.227 1.00 46.05  ?  287  ILE   C CG1   1 
ATOM   1078 C CG2   . ILE   A 1 287  ? 154.769 143.721 174.218 1.00 46.45  ?  287  ILE   C CG2   1 
ATOM   1079 C CD1   . ILE   A 1 287  ? 157.737 143.877 173.244 1.00 51.05  ?  287  ILE   C CD1   1 
ATOM   1080 N N     . HIS   A 1 288  ? 153.139 146.754 172.762 1.00 46.27  ?  288  HIS   C N     1 
ATOM   1081 C CA    . HIS   A 1 288  ? 151.689 146.892 172.682 1.00 46.38  ?  288  HIS   C CA    1 
ATOM   1082 C C     . HIS   A 1 288  ? 151.205 147.327 171.304 1.00 50.40  ?  288  HIS   C C     1 
ATOM   1083 O O     . HIS   A 1 288  ? 150.003 147.517 171.100 1.00 59.37  ?  288  HIS   C O     1 
ATOM   1084 C CB    . HIS   A 1 288  ? 151.192 147.927 173.696 1.00 47.36  ?  288  HIS   C CB    1 
ATOM   1085 C CG    . HIS   A 1 288  ? 151.273 147.513 175.124 1.00 54.13  ?  288  HIS   C CG    1 
ATOM   1086 N ND1   . HIS   A 1 288  ? 150.377 146.639 175.696 1.00 56.85  ?  288  HIS   C ND1   1 
ATOM   1087 C CD2   . HIS   A 1 288  ? 152.133 147.867 176.105 1.00 56.74  ?  288  HIS   C CD2   1 
ATOM   1088 C CE1   . HIS   A 1 288  ? 150.678 146.476 176.972 1.00 55.61  ?  288  HIS   C CE1   1 
ATOM   1089 N NE2   . HIS   A 1 288  ? 151.741 147.208 177.244 1.00 57.21  ?  288  HIS   C NE2   1 
ATOM   1090 N N     . LYS   A 1 289  ? 152.127 147.521 170.367 1.00 50.19  ?  289  LYS   C N     1 
ATOM   1091 C CA    . LYS   A 1 289  ? 151.743 147.995 169.047 1.00 52.59  ?  289  LYS   C CA    1 
ATOM   1092 C C     . LYS   A 1 289  ? 151.824 146.872 168.028 1.00 51.66  ?  289  LYS   C C     1 
ATOM   1093 O O     . LYS   A 1 289  ? 151.226 145.816 168.213 1.00 55.81  ?  289  LYS   C O     1 
ATOM   1094 C CB    . LYS   A 1 289  ? 152.627 149.168 168.622 1.00 56.22  ?  289  LYS   C CB    1 
ATOM   1095 C CG    . LYS   A 1 289  ? 152.592 150.374 169.570 1.00 56.07  ?  289  LYS   C CG    1 
ATOM   1096 C CD    . LYS   A 1 289  ? 151.216 151.031 169.605 1.00 54.72  ?  289  LYS   C CD    1 
ATOM   1097 C CE    . LYS   A 1 289  ? 151.225 152.287 170.461 1.00 55.45  ?  289  LYS   C CE    1 
ATOM   1098 N NZ    . LYS   A 1 289  ? 149.878 152.915 170.534 1.00 54.31  1  289  LYS   C NZ    1 
ATOM   1099 N N     . ILE   A 1 290  ? 152.575 147.080 166.952 1.00 53.99  ?  290  ILE   C N     1 
ATOM   1100 C CA    . ILE   A 1 290  ? 152.634 146.086 165.887 1.00 60.57  ?  290  ILE   C CA    1 
ATOM   1101 C C     . ILE   A 1 290  ? 153.187 144.750 166.375 1.00 59.74  ?  290  ILE   C C     1 
ATOM   1102 O O     . ILE   A 1 290  ? 152.843 143.701 165.835 1.00 53.84  ?  290  ILE   C O     1 
ATOM   1103 C CB    . ILE   A 1 290  ? 153.459 146.600 164.694 1.00 57.05  ?  290  ILE   C CB    1 
ATOM   1104 C CG1   . ILE   A 1 290  ? 153.188 145.712 163.459 1.00 47.05  ?  290  ILE   C CG1   1 
ATOM   1105 C CG2   . ILE   A 1 290  ? 154.934 146.618 165.049 1.00 57.79  ?  290  ILE   C CG2   1 
ATOM   1106 C CD1   . ILE   A 1 290  ? 153.691 146.297 162.156 1.00 47.59  ?  290  ILE   C CD1   1 
ATOM   1107 N N     . VAL   A 1 291  ? 154.019 144.786 167.410 1.00 49.15  ?  291  VAL   C N     1 
ATOM   1108 C CA    . VAL   A 1 291  ? 154.606 143.582 167.986 1.00 46.75  ?  291  VAL   C CA    1 
ATOM   1109 C C     . VAL   A 1 291  ? 153.526 142.672 168.573 1.00 48.79  ?  291  VAL   C C     1 
ATOM   1110 O O     . VAL   A 1 291  ? 153.745 141.478 168.785 1.00 43.59  ?  291  VAL   C O     1 
ATOM   1111 C CB    . VAL   A 1 291  ? 155.619 143.973 169.075 1.00 45.72  ?  291  VAL   C CB    1 
ATOM   1112 C CG1   . VAL   A 1 291  ? 156.121 142.744 169.806 1.00 49.35  ?  291  VAL   C CG1   1 
ATOM   1113 C CG2   . VAL   A 1 291  ? 156.776 144.715 168.446 1.00 43.89  ?  291  VAL   C CG2   1 
ATOM   1114 N N     . ARG   A 1 292  ? 152.371 143.259 168.854 1.00 48.86  ?  292  ARG   C N     1 
ATOM   1115 C CA    . ARG   A 1 292  ? 151.241 142.578 169.460 1.00 46.97  ?  292  ARG   C CA    1 
ATOM   1116 C C     . ARG   A 1 292  ? 150.417 141.767 168.469 1.00 45.09  ?  292  ARG   C C     1 
ATOM   1117 O O     . ARG   A 1 292  ? 149.640 140.905 168.878 1.00 49.92  ?  292  ARG   C O     1 
ATOM   1118 C CB    . ARG   A 1 292  ? 150.337 143.603 170.121 1.00 58.41  ?  292  ARG   C CB    1 
ATOM   1119 C CG    . ARG   A 1 292  ? 149.120 143.058 170.826 1.00 74.64  ?  292  ARG   C CG    1 
ATOM   1120 C CD    . ARG   A 1 292  ? 148.372 144.146 171.509 1.00 81.29  ?  292  ARG   C CD    1 
ATOM   1121 N NE    . ARG   A 1 292  ? 147.992 145.204 170.577 1.00 72.67  ?  292  ARG   C NE    1 
ATOM   1122 C CZ    . ARG   A 1 292  ? 146.956 145.141 169.708 1.00 76.81  ?  292  ARG   C CZ    1 
ATOM   1123 N NH1   . ARG   A 1 292  ? 146.194 144.066 169.656 1.00 76.01  1  292  ARG   C NH1   1 
ATOM   1124 N NH2   . ARG   A 1 292  ? 146.706 146.161 168.905 1.00 69.38  ?  292  ARG   C NH2   1 
ATOM   1125 N N     . LYS   A 1 293  ? 150.523 142.077 167.177 1.00 43.60  ?  293  LYS   C N     1 
ATOM   1126 C CA    . LYS   A 1 293  ? 149.644 141.463 166.189 1.00 43.46  ?  293  LYS   C CA    1 
ATOM   1127 C C     . LYS   A 1 293  ? 149.943 139.965 165.984 1.00 41.47  ?  293  LYS   C C     1 
ATOM   1128 O O     . LYS   A 1 293  ? 151.082 139.598 165.694 1.00 38.11  ?  293  LYS   C O     1 
ATOM   1129 C CB    . LYS   A 1 293  ? 149.757 142.208 164.862 1.00 42.90  ?  293  LYS   C CB    1 
ATOM   1130 C CG    . LYS   A 1 293  ? 148.779 141.751 163.802 1.00 38.86  ?  293  LYS   C CG    1 
ATOM   1131 C CD    . LYS   A 1 293  ? 148.786 142.695 162.620 1.00 39.19  ?  293  LYS   C CD    1 
ATOM   1132 C CE    . LYS   A 1 293  ? 147.952 142.157 161.473 1.00 39.99  ?  293  LYS   C CE    1 
ATOM   1133 N NZ    . LYS   A 1 293  ? 146.499 142.155 161.791 1.00 52.80  1  293  LYS   C NZ    1 
ATOM   1134 N N     . PRO   A 1 294  ? 148.937 139.088 166.136 1.00 36.50  ?  294  PRO   C N     1 
ATOM   1135 C CA    . PRO   A 1 294  ? 148.970 137.659 165.867 1.00 32.90  ?  294  PRO   C CA    1 
ATOM   1136 C C     . PRO   A 1 294  ? 149.174 137.392 164.380 1.00 38.37  ?  294  PRO   C C     1 
ATOM   1137 O O     . PRO   A 1 294  ? 148.897 138.256 163.550 1.00 39.79  ?  294  PRO   C O     1 
ATOM   1138 C CB    . PRO   A 1 294  ? 147.579 137.191 166.316 1.00 39.66  ?  294  PRO   C CB    1 
ATOM   1139 C CG    . PRO   A 1 294  ? 147.066 138.271 167.227 1.00 46.59  ?  294  PRO   C CG    1 
ATOM   1140 C CD    . PRO   A 1 294  ? 147.662 139.545 166.713 1.00 45.03  ?  294  PRO   C CD    1 
ATOM   1141 N N     . SER   A 1 295  ? 149.659 136.195 164.056 1.00 37.25  ?  295  SER   C N     1 
ATOM   1142 C CA    . SER   A 1 295  ? 149.852 135.740 162.676 1.00 33.50  ?  295  SER   C CA    1 
ATOM   1143 C C     . SER   A 1 295  ? 150.981 136.464 161.957 1.00 30.25  ?  295  SER   C C     1 
ATOM   1144 O O     . SER   A 1 295  ? 151.224 136.216 160.778 1.00 32.43  ?  295  SER   C O     1 
ATOM   1145 C CB    . SER   A 1 295  ? 148.575 135.899 161.867 1.00 38.90  ?  295  SER   C CB    1 
ATOM   1146 O OG    . SER   A 1 295  ? 147.513 135.191 162.442 1.00 45.19  ?  295  SER   C OG    1 
ATOM   1147 N N     . ARG   A 1 296  ? 151.673 137.354 162.662 1.00 29.61  ?  296  ARG   C N     1 
ATOM   1148 C CA    . ARG   A 1 296  ? 152.766 138.097 162.061 1.00 31.79  ?  296  ARG   C CA    1 
ATOM   1149 C C     . ARG   A 1 296  ? 154.094 137.839 162.749 1.00 30.03  ?  296  ARG   C C     1 
ATOM   1150 O O     . ARG   A 1 296  ? 155.097 138.487 162.443 1.00 31.12  ?  296  ARG   C O     1 
ATOM   1151 C CB    . ARG   A 1 296  ? 152.465 139.583 162.076 1.00 37.42  ?  296  ARG   C CB    1 
ATOM   1152 C CG    . ARG   A 1 296  ? 151.213 140.002 161.322 1.00 40.78  ?  296  ARG   C CG    1 
ATOM   1153 C CD    . ARG   A 1 296  ? 151.319 139.759 159.854 1.00 39.50  ?  296  ARG   C CD    1 
ATOM   1154 N NE    . ARG   A 1 296  ? 152.394 140.527 159.242 1.00 31.74  ?  296  ARG   C NE    1 
ATOM   1155 C CZ    . ARG   A 1 296  ? 152.852 140.342 157.982 1.00 34.94  ?  296  ARG   C CZ    1 
ATOM   1156 N NH1   . ARG   A 1 296  ? 152.319 139.408 157.217 1.00 32.65  1  296  ARG   C NH1   1 
ATOM   1157 N NH2   . ARG   A 1 296  ? 153.841 141.098 157.525 1.00 37.32  ?  296  ARG   C NH2   1 
ATOM   1158 N N     . ILE   A 1 297  ? 154.121 136.892 163.672 1.00 22.76  ?  297  ILE   C N     1 
ATOM   1159 C CA    . ILE   A 1 297  ? 155.377 136.598 164.334 1.00 19.67  ?  297  ILE   C CA    1 
ATOM   1160 C C     . ILE   A 1 297  ? 155.691 135.120 164.288 1.00 20.19  ?  297  ILE   C C     1 
ATOM   1161 O O     . ILE   A 1 297  ? 154.789 134.286 164.199 1.00 27.90  ?  297  ILE   C O     1 
ATOM   1162 C CB    . ILE   A 1 297  ? 155.368 137.080 165.793 1.00 17.83  ?  297  ILE   C CB    1 
ATOM   1163 C CG1   . ILE   A 1 297  ? 154.328 136.311 166.615 1.00 20.49  ?  297  ILE   C CG1   1 
ATOM   1164 C CG2   . ILE   A 1 297  ? 155.071 138.576 165.828 1.00 28.29  ?  297  ILE   C CG2   1 
ATOM   1165 C CD1   . ILE   A 1 297  ? 154.427 136.572 168.103 1.00 26.06  ?  297  ILE   C CD1   1 
ATOM   1166 N N     . LEU   A 1 298  ? 156.972 134.804 164.379 1.00 20.98  ?  298  LEU   C N     1 
ATOM   1167 C CA    . LEU   A 1 298  ? 157.426 133.425 164.443 1.00 19.88  ?  298  LEU   C CA    1 
ATOM   1168 C C     . LEU   A 1 298  ? 158.406 133.215 165.587 1.00 21.06  ?  298  LEU   C C     1 
ATOM   1169 O O     . LEU   A 1 298  ? 159.445 133.871 165.654 1.00 25.79  ?  298  LEU   C O     1 
ATOM   1170 C CB    . LEU   A 1 298  ? 158.082 133.033 163.112 1.00 20.34  ?  298  LEU   C CB    1 
ATOM   1171 C CG    . LEU   A 1 298  ? 158.780 131.666 163.070 1.00 21.98  ?  298  LEU   C CG    1 
ATOM   1172 C CD1   . LEU   A 1 298  ? 157.758 130.571 163.297 1.00 24.18  ?  298  LEU   C CD1   1 
ATOM   1173 C CD2   . LEU   A 1 298  ? 159.461 131.488 161.713 1.00 23.56  ?  298  LEU   C CD2   1 
ATOM   1174 N N     . PHE   A 1 299  ? 158.090 132.282 166.473 1.00 19.23  ?  299  PHE   C N     1 
ATOM   1175 C CA    . PHE   A 1 299  ? 158.994 131.953 167.566 1.00 17.57  ?  299  PHE   C CA    1 
ATOM   1176 C C     . PHE   A 1 299  ? 159.865 130.775 167.179 1.00 21.37  ?  299  PHE   C C     1 
ATOM   1177 O O     . PHE   A 1 299  ? 159.398 129.843 166.528 1.00 24.39  ?  299  PHE   C O     1 
ATOM   1178 C CB    . PHE   A 1 299  ? 158.228 131.580 168.830 1.00 20.20  ?  299  PHE   C CB    1 
ATOM   1179 C CG    . PHE   A 1 299  ? 157.521 132.685 169.487 1.00 21.85  ?  299  PHE   C CG    1 
ATOM   1180 C CD1   . PHE   A 1 299  ? 156.172 132.862 169.292 1.00 24.72  ?  299  PHE   C CD1   1 
ATOM   1181 C CD2   . PHE   A 1 299  ? 158.190 133.544 170.322 1.00 23.34  ?  299  PHE   C CD2   1 
ATOM   1182 C CE1   . PHE   A 1 299  ? 155.506 133.877 169.925 1.00 24.27  ?  299  PHE   C CE1   1 
ATOM   1183 C CE2   . PHE   A 1 299  ? 157.531 134.555 170.952 1.00 27.75  ?  299  PHE   C CE2   1 
ATOM   1184 C CZ    . PHE   A 1 299  ? 156.183 134.725 170.755 1.00 27.16  ?  299  PHE   C CZ    1 
ATOM   1185 N N     . LEU   A 1 300  ? 161.120 130.798 167.608 1.00 21.94  ?  300  LEU   C N     1 
ATOM   1186 C CA    . LEU   A 1 300  ? 162.023 129.678 167.379 1.00 16.87  ?  300  LEU   C CA    1 
ATOM   1187 C C     . LEU   A 1 300  ? 162.562 129.137 168.697 1.00 20.19  ?  300  LEU   C C     1 
ATOM   1188 O O     . LEU   A 1 300  ? 163.322 129.814 169.387 1.00 27.03  ?  300  LEU   C O     1 
ATOM   1189 C CB    . LEU   A 1 300  ? 163.201 130.108 166.494 1.00 14.24  ?  300  LEU   C CB    1 
ATOM   1190 C CG    . LEU   A 1 300  ? 162.894 130.382 165.014 1.00 12.25  ?  300  LEU   C CG    1 
ATOM   1191 C CD1   . LEU   A 1 300  ? 162.433 131.834 164.824 1.00 26.44  ?  300  LEU   C CD1   1 
ATOM   1192 C CD2   . LEU   A 1 300  ? 164.147 130.110 164.197 1.00 5.04   ?  300  LEU   C CD2   1 
ATOM   1193 N N     . MET   A 1 301  ? 162.162 127.920 169.052 1.00 17.74  ?  301  MET   C N     1 
ATOM   1194 C CA    . MET   A 1 301  ? 162.617 127.294 170.292 1.00 19.63  ?  301  MET   C CA    1 
ATOM   1195 C C     . MET   A 1 301  ? 163.751 126.337 170.000 1.00 22.68  ?  301  MET   C C     1 
ATOM   1196 O O     . MET   A 1 301  ? 163.524 125.196 169.592 1.00 27.10  ?  301  MET   C O     1 
ATOM   1197 C CB    . MET   A 1 301  ? 161.476 126.569 170.982 1.00 21.74  ?  301  MET   C CB    1 
ATOM   1198 C CG    . MET   A 1 301  ? 160.406 127.470 171.525 1.00 26.00  ?  301  MET   C CG    1 
ATOM   1199 S SD    . MET   A 1 301  ? 159.014 126.541 172.177 1.00 42.53  ?  301  MET   C SD    1 
ATOM   1200 C CE    . MET   A 1 301  ? 157.957 127.866 172.725 1.00 44.62  ?  301  MET   C CE    1 
ATOM   1201 N N     . ASP   A 1 302  ? 164.974 126.822 170.146 1.00 24.33  ?  302  ASP   C N     1 
ATOM   1202 C CA    . ASP   A 1 302  ? 166.122 126.065 169.690 1.00 22.46  ?  302  ASP   C CA    1 
ATOM   1203 C C     . ASP   A 1 302  ? 166.733 125.177 170.769 1.00 26.88  ?  302  ASP   C C     1 
ATOM   1204 O O     . ASP   A 1 302  ? 167.393 125.663 171.692 1.00 35.52  ?  302  ASP   C O     1 
ATOM   1205 C CB    . ASP   A 1 302  ? 167.184 127.004 169.139 1.00 27.30  ?  302  ASP   C CB    1 
ATOM   1206 C CG    . ASP   A 1 302  ? 168.340 126.273 168.497 1.00 30.53  ?  302  ASP   C CG    1 
ATOM   1207 O OD1   . ASP   A 1 302  ? 168.223 125.093 168.244 1.00 29.35  ?  302  ASP   C OD1   1 
ATOM   1208 O OD2   . ASP   A 1 302  ? 169.344 126.904 168.267 1.00 33.42  -1 302  ASP   C OD2   1 
ATOM   1209 N N     . GLY   A 1 303  ? 166.517 123.867 170.653 1.00 26.83  ?  303  GLY   C N     1 
ATOM   1210 C CA    . GLY   A 1 303  ? 167.063 122.912 171.611 1.00 34.34  ?  303  GLY   C CA    1 
ATOM   1211 C C     . GLY   A 1 303  ? 166.091 122.567 172.728 1.00 36.56  ?  303  GLY   C C     1 
ATOM   1212 O O     . GLY   A 1 303  ? 166.431 122.647 173.905 1.00 40.14  ?  303  GLY   C O     1 
ATOM   1213 N N     . PHE   A 1 304  ? 164.885 122.159 172.371 1.00 32.24  ?  304  PHE   C N     1 
ATOM   1214 C CA    . PHE   A 1 304  ? 163.891 121.805 173.379 1.00 32.25  ?  304  PHE   C CA    1 
ATOM   1215 C C     . PHE   A 1 304  ? 164.462 120.804 174.384 1.00 34.16  ?  304  PHE   C C     1 
ATOM   1216 O O     . PHE   A 1 304  ? 164.225 120.904 175.585 1.00 38.65  ?  304  PHE   C O     1 
ATOM   1217 C CB    . PHE   A 1 304  ? 162.643 121.225 172.728 1.00 30.48  ?  304  PHE   C CB    1 
ATOM   1218 C CG    . PHE   A 1 304  ? 161.581 120.861 173.703 1.00 30.16  ?  304  PHE   C CG    1 
ATOM   1219 C CD1   . PHE   A 1 304  ? 160.713 121.818 174.203 1.00 32.90  ?  304  PHE   C CD1   1 
ATOM   1220 C CD2   . PHE   A 1 304  ? 161.450 119.559 174.131 1.00 32.91  ?  304  PHE   C CD2   1 
ATOM   1221 C CE1   . PHE   A 1 304  ? 159.735 121.468 175.111 1.00 38.93  ?  304  PHE   C CE1   1 
ATOM   1222 C CE2   . PHE   A 1 304  ? 160.477 119.208 175.034 1.00 38.66  ?  304  PHE   C CE2   1 
ATOM   1223 C CZ    . PHE   A 1 304  ? 159.619 120.164 175.525 1.00 41.63  ?  304  PHE   C CZ    1 
ATOM   1224 N N     . ASP   A 1 305  ? 165.211 119.826 173.894 1.00 30.54  ?  305  ASP   C N     1 
ATOM   1225 C CA    . ASP   A 1 305  ? 165.761 118.795 174.760 1.00 32.76  ?  305  ASP   C CA    1 
ATOM   1226 C C     . ASP   A 1 305  ? 166.862 119.311 175.686 1.00 35.47  ?  305  ASP   C C     1 
ATOM   1227 O O     . ASP   A 1 305  ? 167.266 118.613 176.616 1.00 37.38  ?  305  ASP   C O     1 
ATOM   1228 C CB    . ASP   A 1 305  ? 166.289 117.633 173.927 1.00 35.31  ?  305  ASP   C CB    1 
ATOM   1229 C CG    . ASP   A 1 305  ? 167.303 118.064 172.929 1.00 38.59  ?  305  ASP   C CG    1 
ATOM   1230 O OD1   . ASP   A 1 305  ? 166.908 118.615 171.924 1.00 36.14  ?  305  ASP   C OD1   1 
ATOM   1231 O OD2   . ASP   A 1 305  ? 168.467 117.855 173.159 1.00 38.44  -1 305  ASP   C OD2   1 
ATOM   1232 N N     . GLU   A 1 306  ? 167.351 120.526 175.440 1.00 36.53  ?  306  GLU   C N     1 
ATOM   1233 C CA    . GLU   A 1 306  ? 168.400 121.100 176.274 1.00 40.83  ?  306  GLU   C CA    1 
ATOM   1234 C C     . GLU   A 1 306  ? 167.839 121.888 177.451 1.00 42.93  ?  306  GLU   C C     1 
ATOM   1235 O O     . GLU   A 1 306  ? 168.603 122.445 178.243 1.00 47.41  ?  306  GLU   C O     1 
ATOM   1236 C CB    . GLU   A 1 306  ? 169.326 122.019 175.477 1.00 43.97  ?  306  GLU   C CB    1 
ATOM   1237 C CG    . GLU   A 1 306  ? 170.153 121.349 174.395 1.00 49.84  ?  306  GLU   C CG    1 
ATOM   1238 C CD    . GLU   A 1 306  ? 171.016 120.257 174.972 1.00 59.42  ?  306  GLU   C CD    1 
ATOM   1239 O OE1   . GLU   A 1 306  ? 171.542 120.469 176.037 1.00 60.75  ?  306  GLU   C OE1   1 
ATOM   1240 O OE2   . GLU   A 1 306  ? 171.155 119.221 174.368 1.00 55.85  -1 306  GLU   C OE2   1 
ATOM   1241 N N     . LEU   A 1 307  ? 166.518 121.957 177.568 1.00 38.72  ?  307  LEU   C N     1 
ATOM   1242 C CA    . LEU   A 1 307  ? 165.920 122.687 178.679 1.00 36.42  ?  307  LEU   C CA    1 
ATOM   1243 C C     . LEU   A 1 307  ? 166.389 122.082 179.987 1.00 40.14  ?  307  LEU   C C     1 
ATOM   1244 O O     . LEU   A 1 307  ? 166.347 120.866 180.164 1.00 45.52  ?  307  LEU   C O     1 
ATOM   1245 C CB    . LEU   A 1 307  ? 164.396 122.611 178.601 1.00 34.62  ?  307  LEU   C CB    1 
ATOM   1246 C CG    . LEU   A 1 307  ? 163.742 123.360 177.443 1.00 36.66  ?  307  LEU   C CG    1 
ATOM   1247 C CD1   . LEU   A 1 307  ? 162.314 122.890 177.309 1.00 40.37  ?  307  LEU   C CD1   1 
ATOM   1248 C CD2   . LEU   A 1 307  ? 163.785 124.865 177.702 1.00 40.07  ?  307  LEU   C CD2   1 
ATOM   1249 N N     . GLN   A 1 308  ? 166.844 122.925 180.899 1.00 43.61  ?  308  GLN   C N     1 
ATOM   1250 C CA    . GLN   A 1 308  ? 167.346 122.442 182.172 1.00 51.19  ?  308  GLN   C CA    1 
ATOM   1251 C C     . GLN   A 1 308  ? 166.312 122.576 183.274 1.00 60.35  ?  308  GLN   C C     1 
ATOM   1252 O O     . GLN   A 1 308  ? 165.863 123.677 183.598 1.00 61.09  ?  308  GLN   C O     1 
ATOM   1253 C CB    . GLN   A 1 308  ? 168.636 123.169 182.535 1.00 58.61  ?  308  GLN   C CB    1 
ATOM   1254 C CG    . GLN   A 1 308  ? 169.745 122.929 181.538 1.00 57.86  ?  308  GLN   C CG    1 
ATOM   1255 C CD    . GLN   A 1 308  ? 170.079 121.463 181.425 1.00 61.49  ?  308  GLN   C CD    1 
ATOM   1256 O OE1   . GLN   A 1 308  ? 170.560 120.845 182.371 1.00 61.67  ?  308  GLN   C OE1   1 
ATOM   1257 N NE2   . GLN   A 1 308  ? 169.811 120.890 180.268 1.00 56.61  ?  308  GLN   C NE2   1 
ATOM   1258 N N     . GLY   A 1 309  ? 165.932 121.439 183.836 1.00 60.84  ?  309  GLY   C N     1 
ATOM   1259 C CA    . GLY   A 1 309  ? 164.909 121.369 184.867 1.00 63.58  ?  309  GLY   C CA    1 
ATOM   1260 C C     . GLY   A 1 309  ? 163.875 120.322 184.492 1.00 61.01  ?  309  GLY   C C     1 
ATOM   1261 O O     . GLY   A 1 309  ? 163.723 119.977 183.321 1.00 55.49  ?  309  GLY   C O     1 
ATOM   1262 N N     . ALA   A 1 310  ? 163.162 119.804 185.481 1.00 59.22  ?  310  ALA   C N     1 
ATOM   1263 C CA    . ALA   A 1 310  ? 162.131 118.825 185.185 1.00 55.56  ?  310  ALA   C CA    1 
ATOM   1264 C C     . ALA   A 1 310  ? 161.024 119.500 184.402 1.00 51.31  ?  310  ALA   C C     1 
ATOM   1265 O O     . ALA   A 1 310  ? 160.657 120.637 184.692 1.00 54.92  ?  310  ALA   C O     1 
ATOM   1266 C CB    . ALA   A 1 310  ? 161.586 118.208 186.462 1.00 59.45  ?  310  ALA   C CB    1 
ATOM   1267 N N     . PHE   A 1 311  ? 160.487 118.803 183.416 1.00 48.39  ?  311  PHE   C N     1 
ATOM   1268 C CA    . PHE   A 1 311  ? 159.417 119.362 182.613 1.00 49.83  ?  311  PHE   C CA    1 
ATOM   1269 C C     . PHE   A 1 311  ? 158.285 118.368 182.429 1.00 53.90  ?  311  PHE   C C     1 
ATOM   1270 O O     . PHE   A 1 311  ? 158.494 117.252 181.953 1.00 53.04  ?  311  PHE   C O     1 
ATOM   1271 C CB    . PHE   A 1 311  ? 159.958 119.792 181.255 1.00 45.82  ?  311  PHE   C CB    1 
ATOM   1272 C CG    . PHE   A 1 311  ? 158.939 120.406 180.381 1.00 47.84  ?  311  PHE   C CG    1 
ATOM   1273 C CD1   . PHE   A 1 311  ? 158.560 121.725 180.543 1.00 50.37  ?  311  PHE   C CD1   1 
ATOM   1274 C CD2   . PHE   A 1 311  ? 158.345 119.662 179.394 1.00 50.35  ?  311  PHE   C CD2   1 
ATOM   1275 C CE1   . PHE   A 1 311  ? 157.600 122.281 179.730 1.00 53.98  ?  311  PHE   C CE1   1 
ATOM   1276 C CE2   . PHE   A 1 311  ? 157.391 120.206 178.587 1.00 50.53  ?  311  PHE   C CE2   1 
ATOM   1277 C CZ    . PHE   A 1 311  ? 157.015 121.522 178.750 1.00 50.78  ?  311  PHE   C CZ    1 
ATOM   1278 N N     . ASP   A 1 312  ? 157.083 118.782 182.809 1.00 56.57  ?  312  ASP   C N     1 
ATOM   1279 C CA    . ASP   A 1 312  ? 155.902 117.941 182.689 1.00 57.89  ?  312  ASP   C CA    1 
ATOM   1280 C C     . ASP   A 1 312  ? 154.926 118.503 181.675 1.00 61.21  ?  312  ASP   C C     1 
ATOM   1281 O O     . ASP   A 1 312  ? 154.795 119.717 181.531 1.00 63.18  ?  312  ASP   C O     1 
ATOM   1282 C CB    . ASP   A 1 312  ? 155.193 117.814 184.039 1.00 61.95  ?  312  ASP   C CB    1 
ATOM   1283 C CG    . ASP   A 1 312  ? 156.009 117.080 185.083 1.00 63.39  ?  312  ASP   C CG    1 
ATOM   1284 O OD1   . ASP   A 1 312  ? 156.511 116.022 184.788 1.00 62.21  ?  312  ASP   C OD1   1 
ATOM   1285 O OD2   . ASP   A 1 312  ? 156.121 117.583 186.174 1.00 63.21  -1 312  ASP   C OD2   1 
ATOM   1286 N N     . GLU   A 1 313  ? 154.190 117.615 181.019 1.00 63.42  ?  313  GLU   C N     1 
ATOM   1287 C CA    . GLU   A 1 313  ? 153.106 118.022 180.136 1.00 66.73  ?  313  GLU   C CA    1 
ATOM   1288 C C     . GLU   A 1 313  ? 151.829 118.250 180.937 1.00 67.04  ?  313  GLU   C C     1 
ATOM   1289 O O     . GLU   A 1 313  ? 150.860 118.834 180.447 1.00 65.11  ?  313  GLU   C O     1 
ATOM   1290 C CB    . GLU   A 1 313  ? 152.872 116.962 179.052 1.00 63.83  ?  313  GLU   C CB    1 
ATOM   1291 C CG    . GLU   A 1 313  ? 152.238 115.648 179.548 1.00 68.30  ?  313  GLU   C CG    1 
ATOM   1292 C CD    . GLU   A 1 313  ? 153.246 114.680 180.114 1.00 68.10  ?  313  GLU   C CD    1 
ATOM   1293 O OE1   . GLU   A 1 313  ? 154.295 115.124 180.511 1.00 66.50  ?  313  GLU   C OE1   1 
ATOM   1294 O OE2   . GLU   A 1 313  ? 152.971 113.505 180.152 1.00 66.71  -1 313  GLU   C OE2   1 
ATOM   1295 N N     . HIS   A 1 314  ? 151.832 117.774 182.175 1.00 68.47  ?  314  HIS   C N     1 
ATOM   1296 C CA    . HIS   A 1 314  ? 150.654 117.804 183.028 1.00 69.42  ?  314  HIS   C CA    1 
ATOM   1297 C C     . HIS   A 1 314  ? 150.503 119.133 183.743 1.00 68.44  ?  314  HIS   C C     1 
ATOM   1298 O O     . HIS   A 1 314  ? 150.624 119.212 184.966 1.00 68.47  ?  314  HIS   C O     1 
ATOM   1299 C CB    . HIS   A 1 314  ? 150.726 116.680 184.060 1.00 74.37  ?  314  HIS   C CB    1 
ATOM   1300 C CG    . HIS   A 1 314  ? 150.754 115.328 183.446 1.00 73.44  ?  314  HIS   C CG    1 
ATOM   1301 N ND1   . HIS   A 1 314  ? 149.650 114.754 182.856 1.00 74.88  ?  314  HIS   C ND1   1 
ATOM   1302 C CD2   . HIS   A 1 314  ? 151.759 114.437 183.313 1.00 72.52  ?  314  HIS   C CD2   1 
ATOM   1303 C CE1   . HIS   A 1 314  ? 149.977 113.563 182.389 1.00 78.45  ?  314  HIS   C CE1   1 
ATOM   1304 N NE2   . HIS   A 1 314  ? 151.250 113.348 182.654 1.00 75.61  ?  314  HIS   C NE2   1 
ATOM   1305 N N     . ILE   A 1 315  ? 150.237 120.179 182.977 1.00 67.68  ?  315  ILE   C N     1 
ATOM   1306 C CA    . ILE   A 1 315  ? 150.080 121.503 183.552 1.00 71.06  ?  315  ILE   C CA    1 
ATOM   1307 C C     . ILE   A 1 315  ? 148.659 122.018 183.421 1.00 73.48  ?  315  ILE   C C     1 
ATOM   1308 O O     . ILE   A 1 315  ? 148.157 122.233 182.318 1.00 69.84  ?  315  ILE   C O     1 
ATOM   1309 C CB    . ILE   A 1 315  ? 151.060 122.499 182.911 1.00 67.50  ?  315  ILE   C CB    1 
ATOM   1310 C CG1   . ILE   A 1 315  ? 152.504 122.031 183.199 1.00 69.07  ?  315  ILE   C CG1   1 
ATOM   1311 C CG2   . ILE   A 1 315  ? 150.800 123.921 183.435 1.00 64.55  ?  315  ILE   C CG2   1 
ATOM   1312 C CD1   . ILE   A 1 315  ? 153.575 122.790 182.448 1.00 65.78  ?  315  ILE   C CD1   1 
ATOM   1313 N N     . GLY   A 1 316  ? 148.033 122.242 184.570 1.00 76.35  ?  316  GLY   C N     1 
ATOM   1314 C CA    . GLY   A 1 316  ? 146.692 122.801 184.650 1.00 77.86  ?  316  GLY   C CA    1 
ATOM   1315 C C     . GLY   A 1 316  ? 146.684 124.297 184.332 1.00 71.16  ?  316  GLY   C C     1 
ATOM   1316 O O     . GLY   A 1 316  ? 146.129 124.719 183.317 1.00 67.30  ?  316  GLY   C O     1 
ATOM   1317 N N     . PRO   A 1 317  ? 147.294 125.119 185.193 1.00 69.38  ?  317  PRO   C N     1 
ATOM   1318 C CA    . PRO   A 1 317  ? 147.307 126.564 185.142 1.00 67.68  ?  317  PRO   C CA    1 
ATOM   1319 C C     . PRO   A 1 317  ? 148.270 127.061 184.084 1.00 64.84  ?  317  PRO   C C     1 
ATOM   1320 O O     . PRO   A 1 317  ? 149.362 127.522 184.401 1.00 65.51  ?  317  PRO   C O     1 
ATOM   1321 C CB    . PRO   A 1 317  ? 147.756 126.933 186.560 1.00 67.24  ?  317  PRO   C CB    1 
ATOM   1322 C CG    . PRO   A 1 317  ? 148.643 125.790 186.986 1.00 66.61  ?  317  PRO   C CG    1 
ATOM   1323 C CD    . PRO   A 1 317  ? 148.045 124.556 186.333 1.00 65.47  ?  317  PRO   C CD    1 
ATOM   1324 N N     . LEU   A 1 318  ? 147.864 126.943 182.823 1.00 58.94  ?  318  LEU   C N     1 
ATOM   1325 C CA    . LEU   A 1 318  ? 148.718 127.327 181.706 1.00 56.14  ?  318  LEU   C CA    1 
ATOM   1326 C C     . LEU   A 1 318  ? 149.007 128.820 181.727 1.00 58.63  ?  318  LEU   C C     1 
ATOM   1327 O O     . LEU   A 1 318  ? 150.059 129.258 181.270 1.00 57.73  ?  318  LEU   C O     1 
ATOM   1328 C CB    . LEU   A 1 318  ? 148.068 126.931 180.378 1.00 53.16  ?  318  LEU   C CB    1 
ATOM   1329 C CG    . LEU   A 1 318  ? 147.933 125.414 180.126 1.00 56.97  ?  318  LEU   C CG    1 
ATOM   1330 C CD1   . LEU   A 1 318  ? 147.142 125.199 178.857 1.00 55.29  ?  318  LEU   C CD1   1 
ATOM   1331 C CD2   . LEU   A 1 318  ? 149.321 124.775 180.007 1.00 61.68  ?  318  LEU   C CD2   1 
ATOM   1332 N N     . CYS   A 1 319  ? 148.079 129.598 182.270 1.00 61.55  ?  319  CYS   C N     1 
ATOM   1333 C CA    . CYS   A 1 319  ? 148.279 131.030 182.455 1.00 65.45  ?  319  CYS   C CA    1 
ATOM   1334 C C     . CYS   A 1 319  ? 148.594 131.794 181.174 1.00 55.81  ?  319  CYS   C C     1 
ATOM   1335 O O     . CYS   A 1 319  ? 149.743 132.151 180.910 1.00 52.53  ?  319  CYS   C O     1 
ATOM   1336 C CB    . CYS   A 1 319  ? 149.395 131.271 183.472 1.00 65.76  ?  319  CYS   C CB    1 
ATOM   1337 S SG    . CYS   A 1 319  ? 149.023 130.618 185.123 1.00 73.48  ?  319  CYS   C SG    1 
ATOM   1338 N N     . THR   A 1 320  ? 147.552 132.076 180.402 1.00 51.09  ?  320  THR   C N     1 
ATOM   1339 C CA    . THR   A 1 320  ? 147.668 132.904 179.212 1.00 51.55  ?  320  THR   C CA    1 
ATOM   1340 C C     . THR   A 1 320  ? 147.753 134.362 179.649 1.00 52.65  ?  320  THR   C C     1 
ATOM   1341 O O     . THR   A 1 320  ? 147.729 134.643 180.845 1.00 54.99  ?  320  THR   C O     1 
ATOM   1342 C CB    . THR   A 1 320  ? 146.481 132.682 178.264 1.00 50.04  ?  320  THR   C CB    1 
ATOM   1343 O OG1   . THR   A 1 320  ? 145.267 133.062 178.922 1.00 50.43  ?  320  THR   C OG1   1 
ATOM   1344 C CG2   . THR   A 1 320  ? 146.406 131.215 177.864 1.00 47.80  ?  320  THR   C CG2   1 
ATOM   1345 N N     . ASP   A 1 321  ? 147.906 135.273 178.687 1.00 48.34  ?  321  ASP   C N     1 
ATOM   1346 C CA    . ASP   A 1 321  ? 148.145 136.696 178.962 1.00 46.83  ?  321  ASP   C CA    1 
ATOM   1347 C C     . ASP   A 1 321  ? 149.623 136.962 179.217 1.00 45.11  ?  321  ASP   C C     1 
ATOM   1348 O O     . ASP   A 1 321  ? 150.123 136.819 180.331 1.00 48.49  ?  321  ASP   C O     1 
ATOM   1349 C CB    . ASP   A 1 321  ? 147.323 137.216 180.152 1.00 51.93  ?  321  ASP   C CB    1 
ATOM   1350 C CG    . ASP   A 1 321  ? 147.285 138.766 180.227 1.00 61.36  ?  321  ASP   C CG    1 
ATOM   1351 O OD1   . ASP   A 1 321  ? 147.664 139.396 179.257 1.00 58.72  ?  321  ASP   C OD1   1 
ATOM   1352 O OD2   . ASP   A 1 321  ? 146.876 139.299 181.249 1.00 56.53  -1 321  ASP   C OD2   1 
ATOM   1353 N N     . TRP   A 1 322  ? 150.307 137.362 178.156 1.00 44.27  ?  322  TRP   C N     1 
ATOM   1354 C CA    . TRP   A 1 322  ? 151.740 137.624 178.147 1.00 44.01  ?  322  TRP   C CA    1 
ATOM   1355 C C     . TRP   A 1 322  ? 152.186 138.632 179.201 1.00 43.53  ?  322  TRP   C C     1 
ATOM   1356 O O     . TRP   A 1 322  ? 153.363 138.685 179.572 1.00 48.58  ?  322  TRP   C O     1 
ATOM   1357 C CB    . TRP   A 1 322  ? 152.134 138.121 176.759 1.00 40.92  ?  322  TRP   C CB    1 
ATOM   1358 C CG    . TRP   A 1 322  ? 151.473 139.387 176.366 1.00 42.51  ?  322  TRP   C CG    1 
ATOM   1359 C CD1   . TRP   A 1 322  ? 150.315 139.521 175.669 1.00 41.33  ?  322  TRP   C CD1   1 
ATOM   1360 C CD2   . TRP   A 1 322  ? 151.940 140.723 176.630 1.00 51.75  ?  322  TRP   C CD2   1 
ATOM   1361 N NE1   . TRP   A 1 322  ? 150.028 140.848 175.484 1.00 43.55  ?  322  TRP   C NE1   1 
ATOM   1362 C CE2   . TRP   A 1 322  ? 151.012 141.597 176.072 1.00 50.20  ?  322  TRP   C CE2   1 
ATOM   1363 C CE3   . TRP   A 1 322  ? 153.049 141.238 177.298 1.00 58.31  ?  322  TRP   C CE3   1 
ATOM   1364 C CZ2   . TRP   A 1 322  ? 151.167 142.967 176.144 1.00 53.87  ?  322  TRP   C CZ2   1 
ATOM   1365 C CZ3   . TRP   A 1 322  ? 153.205 142.608 177.374 1.00 53.08  ?  322  TRP   C CZ3   1 
ATOM   1366 C CH2   . TRP   A 1 322  ? 152.289 143.449 176.817 1.00 50.77  ?  322  TRP   C CH2   1 
ATOM   1367 N N     . GLN   A 1 323  ? 151.252 139.440 179.676 1.00 43.41  ?  323  GLN   C N     1 
ATOM   1368 C CA    . GLN   A 1 323  ? 151.544 140.493 180.636 1.00 50.21  ?  323  GLN   C CA    1 
ATOM   1369 C C     . GLN   A 1 323  ? 151.868 139.963 182.029 1.00 50.94  ?  323  GLN   C C     1 
ATOM   1370 O O     . GLN   A 1 323  ? 152.425 140.687 182.854 1.00 50.85  ?  323  GLN   C O     1 
ATOM   1371 C CB    . GLN   A 1 323  ? 150.351 141.442 180.740 1.00 56.47  ?  323  GLN   C CB    1 
ATOM   1372 C CG    . GLN   A 1 323  ? 150.061 142.202 179.479 1.00 56.59  ?  323  GLN   C CG    1 
ATOM   1373 C CD    . GLN   A 1 323  ? 148.831 143.057 179.594 1.00 55.74  ?  323  GLN   C CD    1 
ATOM   1374 O OE1   . GLN   A 1 323  ? 148.918 144.256 179.878 1.00 61.13  ?  323  GLN   C OE1   1 
ATOM   1375 N NE2   . GLN   A 1 323  ? 147.668 142.449 179.383 1.00 46.40  ?  323  GLN   C NE2   1 
ATOM   1376 N N     . LYS   A 1 324  ? 151.484 138.722 182.314 1.00 52.12  ?  324  LYS   C N     1 
ATOM   1377 C CA    . LYS   A 1 324  ? 151.666 138.180 183.655 1.00 55.13  ?  324  LYS   C CA    1 
ATOM   1378 C C     . LYS   A 1 324  ? 152.872 137.261 183.741 1.00 52.18  ?  324  LYS   C C     1 
ATOM   1379 O O     . LYS   A 1 324  ? 153.186 136.541 182.793 1.00 54.37  ?  324  LYS   C O     1 
ATOM   1380 C CB    . LYS   A 1 324  ? 150.409 137.441 184.102 1.00 56.84  ?  324  LYS   C CB    1 
ATOM   1381 C CG    . LYS   A 1 324  ? 149.178 138.334 184.226 1.00 57.33  ?  324  LYS   C CG    1 
ATOM   1382 C CD    . LYS   A 1 324  ? 147.989 137.571 184.800 1.00 58.44  ?  324  LYS   C CD    1 
ATOM   1383 C CE    . LYS   A 1 324  ? 146.759 138.468 184.976 1.00 62.91  ?  324  LYS   C CE    1 
ATOM   1384 N NZ    . LYS   A 1 324  ? 146.010 138.662 183.698 1.00 61.77  1  324  LYS   C NZ    1 
ATOM   1385 N N     . ALA   A 1 325  ? 153.541 137.286 184.890 1.00 52.62  ?  325  ALA   C N     1 
ATOM   1386 C CA    . ALA   A 1 325  ? 154.708 136.447 185.117 1.00 56.77  ?  325  ALA   C CA    1 
ATOM   1387 C C     . ALA   A 1 325  ? 154.322 135.115 185.723 1.00 57.09  ?  325  ALA   C C     1 
ATOM   1388 O O     . ALA   A 1 325  ? 153.522 135.059 186.656 1.00 58.46  ?  325  ALA   C O     1 
ATOM   1389 C CB    . ALA   A 1 325  ? 155.703 137.163 186.018 1.00 57.18  ?  325  ALA   C CB    1 
ATOM   1390 N N     . GLU   A 1 326  ? 154.931 134.048 185.222 1.00 56.65  ?  326  GLU   C N     1 
ATOM   1391 C CA    . GLU   A 1 326  ? 154.668 132.715 185.745 1.00 56.13  ?  326  GLU   C CA    1 
ATOM   1392 C C     . GLU   A 1 326  ? 155.913 131.832 185.605 1.00 55.05  ?  326  GLU   C C     1 
ATOM   1393 O O     . GLU   A 1 326  ? 156.918 132.254 185.037 1.00 55.55  ?  326  GLU   C O     1 
ATOM   1394 C CB    . GLU   A 1 326  ? 153.454 132.131 184.997 1.00 59.39  ?  326  GLU   C CB    1 
ATOM   1395 C CG    . GLU   A 1 326  ? 152.943 130.779 185.463 1.00 66.98  ?  326  GLU   C CG    1 
ATOM   1396 C CD    . GLU   A 1 326  ? 152.655 130.717 186.923 1.00 70.22  ?  326  GLU   C CD    1 
ATOM   1397 O OE1   . GLU   A 1 326  ? 151.542 130.963 187.314 1.00 69.47  ?  326  GLU   C OE1   1 
ATOM   1398 O OE2   . GLU   A 1 326  ? 153.567 130.422 187.653 1.00 67.63  -1 326  GLU   C OE2   1 
ATOM   1399 N N     . ARG   A 1 327  ? 155.837 130.610 186.118 1.00 57.84  ?  327  ARG   C N     1 
ATOM   1400 C CA    . ARG   A 1 327  ? 156.953 129.672 186.055 1.00 59.89  ?  327  ARG   C CA    1 
ATOM   1401 C C     . ARG   A 1 327  ? 157.272 129.333 184.598 1.00 60.25  ?  327  ARG   C C     1 
ATOM   1402 O O     . ARG   A 1 327  ? 156.401 129.402 183.729 1.00 57.16  ?  327  ARG   C O     1 
ATOM   1403 C CB    . ARG   A 1 327  ? 156.627 128.424 186.859 1.00 62.62  ?  327  ARG   C CB    1 
ATOM   1404 C CG    . ARG   A 1 327  ? 157.828 127.704 187.449 1.00 63.25  ?  327  ARG   C CG    1 
ATOM   1405 C CD    . ARG   A 1 327  ? 157.418 126.697 188.456 1.00 62.88  ?  327  ARG   C CD    1 
ATOM   1406 N NE    . ARG   A 1 327  ? 156.707 125.599 187.841 1.00 63.52  ?  327  ARG   C NE    1 
ATOM   1407 C CZ    . ARG   A 1 327  ? 155.983 124.670 188.499 1.00 69.69  ?  327  ARG   C CZ    1 
ATOM   1408 N NH1   . ARG   A 1 327  ? 155.870 124.713 189.813 1.00 72.68  1  327  ARG   C NH1   1 
ATOM   1409 N NH2   . ARG   A 1 327  ? 155.386 123.712 187.813 1.00 70.81  ?  327  ARG   C NH2   1 
ATOM   1410 N N     . GLY   A 1 328  ? 158.545 129.037 184.329 1.00 58.12  ?  328  GLY   C N     1 
ATOM   1411 C CA    . GLY   A 1 328  ? 159.045 128.857 182.970 1.00 56.56  ?  328  GLY   C CA    1 
ATOM   1412 C C     . GLY   A 1 328  ? 158.427 127.691 182.211 1.00 55.92  ?  328  GLY   C C     1 
ATOM   1413 O O     . GLY   A 1 328  ? 158.239 127.775 180.999 1.00 55.43  ?  328  GLY   C O     1 
ATOM   1414 N N     . ASP   A 1 329  ? 158.124 126.601 182.907 1.00 55.10  ?  329  ASP   C N     1 
ATOM   1415 C CA    . ASP   A 1 329  ? 157.558 125.431 182.249 1.00 54.73  ?  329  ASP   C CA    1 
ATOM   1416 C C     . ASP   A 1 329  ? 156.119 125.699 181.883 1.00 53.84  ?  329  ASP   C C     1 
ATOM   1417 O O     . ASP   A 1 329  ? 155.631 125.263 180.840 1.00 53.46  ?  329  ASP   C O     1 
ATOM   1418 C CB    . ASP   A 1 329  ? 157.639 124.222 183.169 1.00 56.67  ?  329  ASP   C CB    1 
ATOM   1419 C CG    . ASP   A 1 329  ? 156.963 124.488 184.487 1.00 60.77  ?  329  ASP   C CG    1 
ATOM   1420 O OD1   . ASP   A 1 329  ? 156.941 125.631 184.895 1.00 60.42  ?  329  ASP   C OD1   1 
ATOM   1421 O OD2   . ASP   A 1 329  ? 156.455 123.564 185.075 1.00 63.73  -1 329  ASP   C OD2   1 
ATOM   1422 N N     . ILE   A 1 330  ? 155.454 126.451 182.736 1.00 52.97  ?  330  ILE   C N     1 
ATOM   1423 C CA    . ILE   A 1 330  ? 154.081 126.838 182.487 1.00 55.63  ?  330  ILE   C CA    1 
ATOM   1424 C C     . ILE   A 1 330  ? 154.029 127.804 181.315 1.00 51.74  ?  330  ILE   C C     1 
ATOM   1425 O O     . ILE   A 1 330  ? 153.203 127.651 180.412 1.00 51.35  ?  330  ILE   C O     1 
ATOM   1426 C CB    . ILE   A 1 330  ? 153.456 127.470 183.736 1.00 59.50  ?  330  ILE   C CB    1 
ATOM   1427 C CG1   . ILE   A 1 330  ? 153.348 126.407 184.855 1.00 62.25  ?  330  ILE   C CG1   1 
ATOM   1428 C CG2   . ILE   A 1 330  ? 152.088 128.035 183.393 1.00 60.43  ?  330  ILE   C CG2   1 
ATOM   1429 C CD1   . ILE   A 1 330  ? 152.997 126.967 186.220 1.00 66.11  ?  330  ILE   C CD1   1 
ATOM   1430 N N     . LEU   A 1 331  ? 154.923 128.788 181.316 1.00 51.71  ?  331  LEU   C N     1 
ATOM   1431 C CA    . LEU   A 1 331  ? 154.968 129.769 180.245 1.00 51.12  ?  331  LEU   C CA    1 
ATOM   1432 C C     . LEU   A 1 331  ? 155.301 129.084 178.924 1.00 49.87  ?  331  LEU   C C     1 
ATOM   1433 O O     . LEU   A 1 331  ? 154.682 129.361 177.894 1.00 50.06  ?  331  LEU   C O     1 
ATOM   1434 C CB    . LEU   A 1 331  ? 156.015 130.851 180.568 1.00 51.24  ?  331  LEU   C CB    1 
ATOM   1435 C CG    . LEU   A 1 331  ? 156.156 132.036 179.562 1.00 52.88  ?  331  LEU   C CG    1 
ATOM   1436 C CD1   . LEU   A 1 331  ? 154.841 132.809 179.480 1.00 47.60  ?  331  LEU   C CD1   1 
ATOM   1437 C CD2   . LEU   A 1 331  ? 157.288 132.958 180.030 1.00 56.46  ?  331  LEU   C CD2   1 
ATOM   1438 N N     . LEU   A 1 332  ? 156.261 128.163 178.968 1.00 51.26  ?  332  LEU   C N     1 
ATOM   1439 C CA    . LEU   A 1 332  ? 156.667 127.418 177.787 1.00 51.22  ?  332  LEU   C CA    1 
ATOM   1440 C C     . LEU   A 1 332  ? 155.535 126.549 177.258 1.00 47.00  ?  332  LEU   C C     1 
ATOM   1441 O O     . LEU   A 1 332  ? 155.263 126.539 176.055 1.00 45.41  ?  332  LEU   C O     1 
ATOM   1442 C CB    . LEU   A 1 332  ? 157.873 126.535 178.129 1.00 48.18  ?  332  LEU   C CB    1 
ATOM   1443 C CG    . LEU   A 1 332  ? 158.396 125.625 177.017 1.00 46.17  ?  332  LEU   C CG    1 
ATOM   1444 C CD1   . LEU   A 1 332  ? 158.894 126.462 175.853 1.00 42.35  ?  332  LEU   C CD1   1 
ATOM   1445 C CD2   . LEU   A 1 332  ? 159.495 124.755 177.570 1.00 53.58  ?  332  LEU   C CD2   1 
ATOM   1446 N N     . SER   A 1 333  ? 154.868 125.823 178.151 1.00 46.23  ?  333  SER   C N     1 
ATOM   1447 C CA    . SER   A 1 333  ? 153.786 124.938 177.754 1.00 44.24  ?  333  SER   C CA    1 
ATOM   1448 C C     . SER   A 1 333  ? 152.661 125.711 177.090 1.00 43.71  ?  333  SER   C C     1 
ATOM   1449 O O     . SER   A 1 333  ? 152.127 125.286 176.065 1.00 44.26  ?  333  SER   C O     1 
ATOM   1450 C CB    . SER   A 1 333  ? 153.260 124.192 178.960 1.00 47.30  ?  333  SER   C CB    1 
ATOM   1451 O OG    . SER   A 1 333  ? 152.197 123.349 178.610 1.00 48.18  ?  333  SER   C OG    1 
ATOM   1452 N N     . SER   A 1 334  ? 152.307 126.854 177.665 1.00 43.92  ?  334  SER   C N     1 
ATOM   1453 C CA    . SER   A 1 334  ? 151.234 127.671 177.123 1.00 47.55  ?  334  SER   C CA    1 
ATOM   1454 C C     . SER   A 1 334  ? 151.558 128.135 175.706 1.00 46.18  ?  334  SER   C C     1 
ATOM   1455 O O     . SER   A 1 334  ? 150.687 128.141 174.831 1.00 46.19  ?  334  SER   C O     1 
ATOM   1456 C CB    . SER   A 1 334  ? 150.982 128.858 178.025 1.00 51.02  ?  334  SER   C CB    1 
ATOM   1457 O OG    . SER   A 1 334  ? 149.911 129.625 177.559 1.00 48.37  ?  334  SER   C OG    1 
ATOM   1458 N N     . LEU   A 1 335  ? 152.813 128.512 175.461 1.00 44.03  ?  335  LEU   C N     1 
ATOM   1459 C CA    . LEU   A 1 335  ? 153.191 128.940 174.122 1.00 39.32  ?  335  LEU   C CA    1 
ATOM   1460 C C     . LEU   A 1 335  ? 153.198 127.763 173.140 1.00 37.20  ?  335  LEU   C C     1 
ATOM   1461 O O     . LEU   A 1 335  ? 152.709 127.886 172.021 1.00 38.81  ?  335  LEU   C O     1 
ATOM   1462 C CB    . LEU   A 1 335  ? 154.557 129.643 174.145 1.00 35.67  ?  335  LEU   C CB    1 
ATOM   1463 C CG    . LEU   A 1 335  ? 155.047 130.262 172.800 1.00 31.66  ?  335  LEU   C CG    1 
ATOM   1464 C CD1   . LEU   A 1 335  ? 154.008 131.252 172.260 1.00 31.81  ?  335  LEU   C CD1   1 
ATOM   1465 C CD2   . LEU   A 1 335  ? 156.366 130.999 173.040 1.00 34.23  ?  335  LEU   C CD2   1 
ATOM   1466 N N     . ILE   A 1 336  ? 153.712 126.610 173.568 1.00 36.69  ?  336  ILE   C N     1 
ATOM   1467 C CA    . ILE   A 1 336  ? 153.761 125.444 172.685 1.00 36.21  ?  336  ILE   C CA    1 
ATOM   1468 C C     . ILE   A 1 336  ? 152.364 124.980 172.305 1.00 40.41  ?  336  ILE   C C     1 
ATOM   1469 O O     . ILE   A 1 336  ? 152.117 124.591 171.163 1.00 43.10  ?  336  ILE   C O     1 
ATOM   1470 C CB    . ILE   A 1 336  ? 154.542 124.272 173.307 1.00 37.41  ?  336  ILE   C CB    1 
ATOM   1471 C CG1   . ILE   A 1 336  ? 156.015 124.649 173.436 1.00 38.95  ?  336  ILE   C CG1   1 
ATOM   1472 C CG2   . ILE   A 1 336  ? 154.393 123.023 172.423 1.00 38.38  ?  336  ILE   C CG2   1 
ATOM   1473 C CD1   . ILE   A 1 336  ? 156.827 123.690 174.268 1.00 41.46  ?  336  ILE   C CD1   1 
ATOM   1474 N N     . ARG   A 1 337  ? 151.444 125.014 173.263 1.00 41.80  ?  337  ARG   C N     1 
ATOM   1475 C CA    . ARG   A 1 337  ? 150.065 124.594 173.041 1.00 43.03  ?  337  ARG   C CA    1 
ATOM   1476 C C     . ARG   A 1 337  ? 149.252 125.637 172.274 1.00 44.12  ?  337  ARG   C C     1 
ATOM   1477 O O     . ARG   A 1 337  ? 148.067 125.431 172.014 1.00 44.81  ?  337  ARG   C O     1 
ATOM   1478 C CB    . ARG   A 1 337  ? 149.355 124.330 174.358 1.00 43.76  ?  337  ARG   C CB    1 
ATOM   1479 C CG    . ARG   A 1 337  ? 149.792 123.102 175.125 1.00 40.42  ?  337  ARG   C CG    1 
ATOM   1480 C CD    . ARG   A 1 337  ? 149.029 123.000 176.398 1.00 43.29  ?  337  ARG   C CD    1 
ATOM   1481 N NE    . ARG   A 1 337  ? 149.370 121.819 177.165 1.00 45.65  ?  337  ARG   C NE    1 
ATOM   1482 C CZ    . ARG   A 1 337  ? 148.869 120.589 176.937 1.00 49.65  ?  337  ARG   C CZ    1 
ATOM   1483 N NH1   . ARG   A 1 337  ? 148.020 120.397 175.950 1.00 51.24  1  337  ARG   C NH1   1 
ATOM   1484 N NH2   . ARG   A 1 337  ? 149.230 119.573 177.703 1.00 52.02  ?  337  ARG   C NH2   1 
ATOM   1485 N N     . LYS   A 1 338  ? 149.880 126.767 171.946 1.00 43.25  ?  338  LYS   C N     1 
ATOM   1486 C CA    . LYS   A 1 338  ? 149.229 127.870 171.249 1.00 44.73  ?  338  LYS   C CA    1 
ATOM   1487 C C     . LYS   A 1 338  ? 148.087 128.476 172.056 1.00 43.43  ?  338  LYS   C C     1 
ATOM   1488 O O     . LYS   A 1 338  ? 147.085 128.915 171.488 1.00 45.97  ?  338  LYS   C O     1 
ATOM   1489 C CB    . LYS   A 1 338  ? 148.697 127.405 169.894 1.00 45.85  ?  338  LYS   C CB    1 
ATOM   1490 C CG    . LYS   A 1 338  ? 149.754 126.824 168.968 1.00 38.70  ?  338  LYS   C CG    1 
ATOM   1491 C CD    . LYS   A 1 338  ? 149.153 126.383 167.636 1.00 42.96  ?  338  LYS   C CD    1 
ATOM   1492 C CE    . LYS   A 1 338  ? 148.321 125.103 167.789 1.00 53.52  ?  338  LYS   C CE    1 
ATOM   1493 N NZ    . LYS   A 1 338  ? 147.758 124.645 166.491 1.00 43.97  1  338  LYS   C NZ    1 
ATOM   1494 N N     . LYS   A 1 339  ? 148.241 128.530 173.375 1.00 39.96  ?  339  LYS   C N     1 
ATOM   1495 C CA    . LYS   A 1 339  ? 147.242 129.163 174.220 1.00 40.89  ?  339  LYS   C CA    1 
ATOM   1496 C C     . LYS   A 1 339  ? 147.673 130.588 174.484 1.00 43.53  ?  339  LYS   C C     1 
ATOM   1497 O O     . LYS   A 1 339  ? 146.851 131.502 174.577 1.00 45.84  ?  339  LYS   C O     1 
ATOM   1498 C CB    . LYS   A 1 339  ? 147.072 128.400 175.530 1.00 42.36  ?  339  LYS   C CB    1 
ATOM   1499 C CG    . LYS   A 1 339  ? 146.621 126.961 175.371 1.00 44.00  ?  339  LYS   C CG    1 
ATOM   1500 C CD    . LYS   A 1 339  ? 145.249 126.874 174.735 1.00 46.43  ?  339  LYS   C CD    1 
ATOM   1501 C CE    . LYS   A 1 339  ? 144.746 125.443 174.699 1.00 54.83  ?  339  LYS   C CE    1 
ATOM   1502 N NZ    . LYS   A 1 339  ? 143.425 125.339 174.021 1.00 63.76  1  339  LYS   C NZ    1 
ATOM   1503 N N     . LEU   A 1 340  ? 148.981 130.771 174.561 1.00 43.18  ?  340  LEU   C N     1 
ATOM   1504 C CA    . LEU   A 1 340  ? 149.579 132.079 174.720 1.00 42.13  ?  340  LEU   C CA    1 
ATOM   1505 C C     . LEU   A 1 340  ? 149.832 132.657 173.347 1.00 38.46  ?  340  LEU   C C     1 
ATOM   1506 O O     . LEU   A 1 340  ? 150.416 131.996 172.490 1.00 41.91  ?  340  LEU   C O     1 
ATOM   1507 C CB    . LEU   A 1 340  ? 150.881 131.974 175.512 1.00 40.54  ?  340  LEU   C CB    1 
ATOM   1508 C CG    . LEU   A 1 340  ? 151.701 133.246 175.659 1.00 40.12  ?  340  LEU   C CG    1 
ATOM   1509 C CD1   . LEU   A 1 340  ? 150.931 134.281 176.461 1.00 45.81  ?  340  LEU   C CD1   1 
ATOM   1510 C CD2   . LEU   A 1 340  ? 152.987 132.898 176.351 1.00 42.87  ?  340  LEU   C CD2   1 
ATOM   1511 N N     . LEU   A 1 341  ? 149.342 133.860 173.115 1.00 33.91  ?  341  LEU   C N     1 
ATOM   1512 C CA    . LEU   A 1 341  ? 149.440 134.476 171.805 1.00 33.19  ?  341  LEU   C CA    1 
ATOM   1513 C C     . LEU   A 1 341  ? 148.991 133.528 170.692 1.00 37.83  ?  341  LEU   C C     1 
ATOM   1514 O O     . LEU   A 1 341  ? 149.807 133.107 169.873 1.00 36.87  ?  341  LEU   C O     1 
ATOM   1515 C CB    . LEU   A 1 341  ? 150.882 134.918 171.534 1.00 30.95  ?  341  LEU   C CB    1 
ATOM   1516 C CG    . LEU   A 1 341  ? 151.486 135.918 172.523 1.00 42.24  ?  341  LEU   C CG    1 
ATOM   1517 C CD1   . LEU   A 1 341  ? 152.937 136.142 172.153 1.00 45.57  ?  341  LEU   C CD1   1 
ATOM   1518 C CD2   . LEU   A 1 341  ? 150.711 137.222 172.482 1.00 42.37  ?  341  LEU   C CD2   1 
ATOM   1519 N N     . PRO   A 1 342  ? 147.699 133.187 170.627 1.00 41.12  ?  342  PRO   C N     1 
ATOM   1520 C CA    . PRO   A 1 342  ? 147.113 132.322 169.629 1.00 36.90  ?  342  PRO   C CA    1 
ATOM   1521 C C     . PRO   A 1 342  ? 147.440 132.872 168.256 1.00 33.51  ?  342  PRO   C C     1 
ATOM   1522 O O     . PRO   A 1 342  ? 147.578 134.079 168.085 1.00 35.56  ?  342  PRO   C O     1 
ATOM   1523 C CB    . PRO   A 1 342  ? 145.613 132.418 169.930 1.00 44.40  ?  342  PRO   C CB    1 
ATOM   1524 C CG    . PRO   A 1 342  ? 145.545 132.789 171.389 1.00 44.88  ?  342  PRO   C CG    1 
ATOM   1525 C CD    . PRO   A 1 342  ? 146.743 133.693 171.616 1.00 46.60  ?  342  PRO   C CD    1 
ATOM   1526 N N     . GLU   A 1 343  ? 147.591 131.978 167.291 1.00 33.93  ?  343  GLU   C N     1 
ATOM   1527 C CA    . GLU   A 1 343  ? 147.947 132.328 165.917 1.00 36.97  ?  343  GLU   C CA    1 
ATOM   1528 C C     . GLU   A 1 343  ? 149.387 132.822 165.784 1.00 30.13  ?  343  GLU   C C     1 
ATOM   1529 O O     . GLU   A 1 343  ? 149.797 133.271 164.713 1.00 28.34  ?  343  GLU   C O     1 
ATOM   1530 C CB    . GLU   A 1 343  ? 146.992 133.377 165.340 1.00 40.69  ?  343  GLU   C CB    1 
ATOM   1531 C CG    . GLU   A 1 343  ? 145.522 133.005 165.417 1.00 48.43  ?  343  GLU   C CG    1 
ATOM   1532 C CD    . GLU   A 1 343  ? 145.184 131.810 164.575 1.00 54.16  ?  343  GLU   C CD    1 
ATOM   1533 O OE1   . GLU   A 1 343  ? 145.791 131.644 163.539 1.00 47.96  ?  343  GLU   C OE1   1 
ATOM   1534 O OE2   . GLU   A 1 343  ? 144.325 131.056 164.966 1.00 50.99  -1 343  GLU   C OE2   1 
ATOM   1535 N N     . ALA   A 1 344  ? 150.176 132.682 166.842 1.00 28.40  ?  344  ALA   C N     1 
ATOM   1536 C CA    . ALA   A 1 344  ? 151.603 132.943 166.740 1.00 23.34  ?  344  ALA   C CA    1 
ATOM   1537 C C     . ALA   A 1 344  ? 152.305 131.680 166.282 1.00 20.20  ?  344  ALA   C C     1 
ATOM   1538 O O     . ALA   A 1 344  ? 152.271 130.659 166.969 1.00 23.89  ?  344  ALA   C O     1 
ATOM   1539 C CB    . ALA   A 1 344  ? 152.165 133.411 168.069 1.00 32.67  ?  344  ALA   C CB    1 
ATOM   1540 N N     . SER   A 1 345  ? 152.923 131.741 165.113 1.00 17.82  ?  345  SER   C N     1 
ATOM   1541 C CA    . SER   A 1 345  ? 153.574 130.568 164.558 1.00 17.64  ?  345  SER   C CA    1 
ATOM   1542 C C     . SER   A 1 345  ? 154.738 130.161 165.433 1.00 20.07  ?  345  SER   C C     1 
ATOM   1543 O O     . SER   A 1 345  ? 155.358 131.001 166.091 1.00 25.04  ?  345  SER   C O     1 
ATOM   1544 C CB    . SER   A 1 345  ? 154.047 130.838 163.149 1.00 20.80  ?  345  SER   C CB    1 
ATOM   1545 O OG    . SER   A 1 345  ? 152.969 131.150 162.313 1.00 23.59  ?  345  SER   C OG    1 
ATOM   1546 N N     . LEU   A 1 346  ? 155.012 128.867 165.468 1.00 18.67  ?  346  LEU   C N     1 
ATOM   1547 C CA    . LEU   A 1 346  ? 156.083 128.354 166.301 1.00 17.01  ?  346  LEU   C CA    1 
ATOM   1548 C C     . LEU   A 1 346  ? 156.911 127.278 165.621 1.00 19.37  ?  346  LEU   C C     1 
ATOM   1549 O O     . LEU   A 1 346  ? 156.378 126.288 165.121 1.00 23.36  ?  346  LEU   C O     1 
ATOM   1550 C CB    . LEU   A 1 346  ? 155.495 127.809 167.604 1.00 16.43  ?  346  LEU   C CB    1 
ATOM   1551 C CG    . LEU   A 1 346  ? 156.469 127.084 168.516 1.00 20.14  ?  346  LEU   C CG    1 
ATOM   1552 C CD1   . LEU   A 1 346  ? 157.539 128.032 168.981 1.00 24.90  ?  346  LEU   C CD1   1 
ATOM   1553 C CD2   . LEU   A 1 346  ? 155.717 126.534 169.703 1.00 29.61  ?  346  LEU   C CD2   1 
ATOM   1554 N N     . LEU   A 1 347  ? 158.223 127.466 165.639 1.00 18.49  ?  347  LEU   C N     1 
ATOM   1555 C CA    . LEU   A 1 347  ? 159.162 126.492 165.115 1.00 13.05  ?  347  LEU   C CA    1 
ATOM   1556 C C     . LEU   A 1 347  ? 159.982 125.907 166.257 1.00 14.47  ?  347  LEU   C C     1 
ATOM   1557 O O     . LEU   A 1 347  ? 160.571 126.644 167.047 1.00 20.35  ?  347  LEU   C O     1 
ATOM   1558 C CB    . LEU   A 1 347  ? 160.086 127.166 164.103 1.00 14.22  ?  347  LEU   C CB    1 
ATOM   1559 C CG    . LEU   A 1 347  ? 161.099 126.287 163.395 1.00 10.72  ?  347  LEU   C CG    1 
ATOM   1560 C CD1   . LEU   A 1 347  ? 160.372 125.337 162.463 1.00 16.12  ?  347  LEU   C CD1   1 
ATOM   1561 C CD2   . LEU   A 1 347  ? 162.053 127.170 162.636 1.00 14.50  ?  347  LEU   C CD2   1 
ATOM   1562 N N     . ILE   A 1 348  ? 160.013 124.589 166.348 1.00 13.26  ?  348  ILE   C N     1 
ATOM   1563 C CA    . ILE   A 1 348  ? 160.750 123.912 167.411 1.00 11.76  ?  348  ILE   C CA    1 
ATOM   1564 C C     . ILE   A 1 348  ? 161.839 123.019 166.851 1.00 14.22  ?  348  ILE   C C     1 
ATOM   1565 O O     . ILE   A 1 348  ? 161.610 122.289 165.890 1.00 16.87  ?  348  ILE   C O     1 
ATOM   1566 C CB    . ILE   A 1 348  ? 159.807 123.054 168.278 1.00 7.32   ?  348  ILE   C CB    1 
ATOM   1567 C CG1   . ILE   A 1 348  ? 158.767 123.937 168.954 1.00 17.58  ?  348  ILE   C CG1   1 
ATOM   1568 C CG2   . ILE   A 1 348  ? 160.608 122.270 169.318 1.00 18.54  ?  348  ILE   C CG2   1 
ATOM   1569 C CD1   . ILE   A 1 348  ? 157.620 123.166 169.564 1.00 28.07  ?  348  ILE   C CD1   1 
ATOM   1570 N N     . THR   A 1 349  ? 163.023 123.065 167.453 1.00 15.36  ?  349  THR   C N     1 
ATOM   1571 C CA    . THR   A 1 349  ? 164.084 122.139 167.071 1.00 13.65  ?  349  THR   C CA    1 
ATOM   1572 C C     . THR   A 1 349  ? 164.369 121.228 168.251 1.00 17.98  ?  349  THR   C C     1 
ATOM   1573 O O     . THR   A 1 349  ? 164.563 121.696 169.379 1.00 24.09  ?  349  THR   C O     1 
ATOM   1574 C CB    . THR   A 1 349  ? 165.381 122.865 166.688 1.00 19.42  ?  349  THR   C CB    1 
ATOM   1575 O OG1   . THR   A 1 349  ? 165.913 123.507 167.849 1.00 24.47  ?  349  THR   C OG1   1 
ATOM   1576 C CG2   . THR   A 1 349  ? 165.112 123.905 165.605 1.00 18.04  ?  349  THR   C CG2   1 
ATOM   1577 N N     . THR   A 1 350  ? 164.419 119.926 168.001 1.00 18.61  ?  350  THR   C N     1 
ATOM   1578 C CA    . THR   A 1 350  ? 164.632 118.994 169.095 1.00 19.82  ?  350  THR   C CA    1 
ATOM   1579 C C     . THR   A 1 350  ? 165.238 117.666 168.662 1.00 22.34  ?  350  THR   C C     1 
ATOM   1580 O O     . THR   A 1 350  ? 165.020 117.202 167.541 1.00 26.13  ?  350  THR   C O     1 
ATOM   1581 C CB    . THR   A 1 350  ? 163.291 118.720 169.783 1.00 23.54  ?  350  THR   C CB    1 
ATOM   1582 O OG1   . THR   A 1 350  ? 163.506 117.983 170.976 1.00 33.16  ?  350  THR   C OG1   1 
ATOM   1583 C CG2   . THR   A 1 350  ? 162.392 117.924 168.852 1.00 20.36  ?  350  THR   C CG2   1 
ATOM   1584 N N     . ARG   A 1 351  ? 165.934 117.014 169.581 1.00 22.98  ?  351  ARG   C N     1 
ATOM   1585 C CA    . ARG   A 1 351  ? 166.305 115.628 169.355 1.00 24.84  ?  351  ARG   C CA    1 
ATOM   1586 C C     . ARG   A 1 351  ? 165.054 114.772 169.499 1.00 29.52  ?  351  ARG   C C     1 
ATOM   1587 O O     . ARG   A 1 351  ? 164.201 115.081 170.329 1.00 33.06  ?  351  ARG   C O     1 
ATOM   1588 C CB    . ARG   A 1 351  ? 167.381 115.172 170.330 1.00 27.03  ?  351  ARG   C CB    1 
ATOM   1589 C CG    . ARG   A 1 351  ? 168.760 115.724 170.069 1.00 29.06  ?  351  ARG   C CG    1 
ATOM   1590 C CD    . ARG   A 1 351  ? 169.756 115.133 170.979 1.00 28.52  ?  351  ARG   C CD    1 
ATOM   1591 N NE    . ARG   A 1 351  ? 169.573 115.589 172.318 1.00 25.71  ?  351  ARG   C NE    1 
ATOM   1592 C CZ    . ARG   A 1 351  ? 170.017 114.977 173.422 1.00 31.43  ?  351  ARG   C CZ    1 
ATOM   1593 N NH1   . ARG   A 1 351  ? 170.681 113.843 173.343 1.00 32.47  1  351  ARG   C NH1   1 
ATOM   1594 N NH2   . ARG   A 1 351  ? 169.776 115.538 174.588 1.00 38.51  ?  351  ARG   C NH2   1 
ATOM   1595 N N     . PRO   A 1 352  ? 164.939 113.669 168.750 1.00 28.76  ?  352  PRO   C N     1 
ATOM   1596 C CA    . PRO   A 1 352  ? 163.792 112.780 168.706 1.00 29.68  ?  352  PRO   C CA    1 
ATOM   1597 C C     . PRO   A 1 352  ? 163.486 112.187 170.076 1.00 33.58  ?  352  PRO   C C     1 
ATOM   1598 O O     . PRO   A 1 352  ? 162.374 111.741 170.345 1.00 36.70  ?  352  PRO   C O     1 
ATOM   1599 C CB    . PRO   A 1 352  ? 164.231 111.716 167.691 1.00 28.36  ?  352  PRO   C CB    1 
ATOM   1600 C CG    . PRO   A 1 352  ? 165.740 111.806 167.654 1.00 28.41  ?  352  PRO   C CG    1 
ATOM   1601 C CD    . PRO   A 1 352  ? 166.046 113.262 167.885 1.00 28.57  ?  352  PRO   C CD    1 
ATOM   1602 N N     . VAL   A 1 353  ? 164.470 112.214 170.955 1.00 31.44  ?  353  VAL   C N     1 
ATOM   1603 C CA    . VAL   A 1 353  ? 164.322 111.665 172.290 1.00 33.84  ?  353  VAL   C CA    1 
ATOM   1604 C C     . VAL   A 1 353  ? 163.305 112.436 173.120 1.00 36.72  ?  353  VAL   C C     1 
ATOM   1605 O O     . VAL   A 1 353  ? 162.703 111.887 174.040 1.00 44.65  ?  353  VAL   C O     1 
ATOM   1606 C CB    . VAL   A 1 353  ? 165.683 111.668 173.003 1.00 36.29  ?  353  VAL   C CB    1 
ATOM   1607 C CG1   . VAL   A 1 353  ? 166.678 110.867 172.193 1.00 32.80  ?  353  VAL   C CG1   1 
ATOM   1608 C CG2   . VAL   A 1 353  ? 166.175 113.096 173.177 1.00 39.96  ?  353  VAL   C CG2   1 
ATOM   1609 N N     . ALA   A 1 354  ? 163.111 113.709 172.794 1.00 32.32  ?  354  ALA   C N     1 
ATOM   1610 C CA    . ALA   A 1 354  ? 162.198 114.555 173.545 1.00 33.14  ?  354  ALA   C CA    1 
ATOM   1611 C C     . ALA   A 1 354  ? 160.800 114.545 172.951 1.00 39.08  ?  354  ALA   C C     1 
ATOM   1612 O O     . ALA   A 1 354  ? 159.909 115.242 173.444 1.00 43.74  ?  354  ALA   C O     1 
ATOM   1613 C CB    . ALA   A 1 354  ? 162.727 115.970 173.600 1.00 35.30  ?  354  ALA   C CB    1 
ATOM   1614 N N     . LEU   A 1 355  ? 160.583 113.746 171.911 1.00 35.81  ?  355  LEU   C N     1 
ATOM   1615 C CA    . LEU   A 1 355  ? 159.260 113.686 171.310 1.00 38.02  ?  355  LEU   C CA    1 
ATOM   1616 C C     . LEU   A 1 355  ? 158.273 113.060 172.283 1.00 44.19  ?  355  LEU   C C     1 
ATOM   1617 O O     . LEU   A 1 355  ? 157.069 113.300 172.197 1.00 46.82  ?  355  LEU   C O     1 
ATOM   1618 C CB    . LEU   A 1 355  ? 159.290 112.908 169.993 1.00 32.96  ?  355  LEU   C CB    1 
ATOM   1619 C CG    . LEU   A 1 355  ? 160.046 113.586 168.833 1.00 32.16  ?  355  LEU   C CG    1 
ATOM   1620 C CD1   . LEU   A 1 355  ? 160.188 112.600 167.687 1.00 33.23  ?  355  LEU   C CD1   1 
ATOM   1621 C CD2   . LEU   A 1 355  ? 159.292 114.831 168.366 1.00 30.02  ?  355  LEU   C CD2   1 
ATOM   1622 N N     . GLU   A 1 356  ? 158.786 112.306 173.254 1.00 41.33  ?  356  GLU   C N     1 
ATOM   1623 C CA    . GLU   A 1 356  ? 157.938 111.715 174.278 1.00 44.71  ?  356  GLU   C CA    1 
ATOM   1624 C C     . GLU   A 1 356  ? 157.235 112.787 175.112 1.00 46.18  ?  356  GLU   C C     1 
ATOM   1625 O O     . GLU   A 1 356  ? 156.212 112.507 175.739 1.00 51.69  ?  356  GLU   C O     1 
ATOM   1626 C CB    . GLU   A 1 356  ? 158.736 110.790 175.206 1.00 47.84  ?  356  GLU   C CB    1 
ATOM   1627 C CG    . GLU   A 1 356  ? 159.169 109.454 174.588 1.00 57.87  ?  356  GLU   C CG    1 
ATOM   1628 C CD    . GLU   A 1 356  ? 159.751 108.490 175.616 1.00 66.15  ?  356  GLU   C CD    1 
ATOM   1629 O OE1   . GLU   A 1 356  ? 159.956 108.901 176.733 1.00 65.08  ?  356  GLU   C OE1   1 
ATOM   1630 O OE2   . GLU   A 1 356  ? 159.978 107.343 175.280 1.00 66.54  -1 356  GLU   C OE2   1 
ATOM   1631 N N     . LYS   A 1 357  ? 157.779 114.008 175.126 1.00 40.85  ?  357  LYS   C N     1 
ATOM   1632 C CA    . LYS   A 1 357  ? 157.163 115.098 175.873 1.00 39.13  ?  357  LYS   C CA    1 
ATOM   1633 C C     . LYS   A 1 357  ? 156.355 116.004 174.948 1.00 41.34  ?  357  LYS   C C     1 
ATOM   1634 O O     . LYS   A 1 357  ? 155.256 116.440 175.293 1.00 48.00  ?  357  LYS   C O     1 
ATOM   1635 C CB    . LYS   A 1 357  ? 158.227 115.932 176.589 1.00 37.53  ?  357  LYS   C CB    1 
ATOM   1636 C CG    . LYS   A 1 357  ? 159.078 115.173 177.601 1.00 40.46  ?  357  LYS   C CG    1 
ATOM   1637 C CD    . LYS   A 1 357  ? 158.231 114.596 178.729 1.00 42.55  ?  357  LYS   C CD    1 
ATOM   1638 C CE    . LYS   A 1 357  ? 159.101 114.034 179.844 1.00 43.77  ?  357  LYS   C CE    1 
ATOM   1639 N NZ    . LYS   A 1 357  ? 158.289 113.355 180.899 1.00 50.28  1  357  LYS   C NZ    1 
ATOM   1640 N N     . LEU   A 1 358  ? 156.895 116.283 173.768 1.00 36.91  ?  358  LEU   C N     1 
ATOM   1641 C CA    . LEU   A 1 358  ? 156.240 117.194 172.835 1.00 39.00  ?  358  LEU   C CA    1 
ATOM   1642 C C     . LEU   A 1 358  ? 154.949 116.623 172.267 1.00 43.04  ?  358  LEU   C C     1 
ATOM   1643 O O     . LEU   A 1 358  ? 154.014 117.366 171.963 1.00 46.91  ?  358  LEU   C O     1 
ATOM   1644 C CB    . LEU   A 1 358  ? 157.183 117.556 171.689 1.00 38.52  ?  358  LEU   C CB    1 
ATOM   1645 C CG    . LEU   A 1 358  ? 158.372 118.463 172.031 1.00 38.19  ?  358  LEU   C CG    1 
ATOM   1646 C CD1   . LEU   A 1 358  ? 159.322 118.481 170.857 1.00 35.55  ?  358  LEU   C CD1   1 
ATOM   1647 C CD2   . LEU   A 1 358  ? 157.873 119.881 172.324 1.00 37.49  ?  358  LEU   C CD2   1 
ATOM   1648 N N     . GLN   A 1 359  ? 154.866 115.302 172.157 1.00 42.27  ?  359  GLN   C N     1 
ATOM   1649 C CA    . GLN   A 1 359  ? 153.676 114.667 171.601 1.00 44.94  ?  359  GLN   C CA    1 
ATOM   1650 C C     . GLN   A 1 359  ? 152.406 115.056 172.354 1.00 48.99  ?  359  GLN   C C     1 
ATOM   1651 O O     . GLN   A 1 359  ? 151.304 114.901 171.831 1.00 52.93  ?  359  GLN   C O     1 
ATOM   1652 C CB    . GLN   A 1 359  ? 153.804 113.143 171.636 1.00 49.18  ?  359  GLN   C CB    1 
ATOM   1653 C CG    . GLN   A 1 359  ? 153.705 112.554 173.033 1.00 51.97  ?  359  GLN   C CG    1 
ATOM   1654 C CD    . GLN   A 1 359  ? 153.864 111.055 173.050 1.00 58.60  ?  359  GLN   C CD    1 
ATOM   1655 O OE1   . GLN   A 1 359  ? 153.332 110.351 172.186 1.00 61.89  ?  359  GLN   C OE1   1 
ATOM   1656 N NE2   . GLN   A 1 359  ? 154.594 110.549 174.037 1.00 56.21  ?  359  GLN   C NE2   1 
ATOM   1657 N N     . HIS   A 1 360  ? 152.551 115.538 173.587 1.00 48.38  ?  360  HIS   C N     1 
ATOM   1658 C CA    . HIS   A 1 360  ? 151.395 115.884 174.401 1.00 49.40  ?  360  HIS   C CA    1 
ATOM   1659 C C     . HIS   A 1 360  ? 151.077 117.374 174.356 1.00 46.06  ?  360  HIS   C C     1 
ATOM   1660 O O     . HIS   A 1 360  ? 150.091 117.820 174.943 1.00 48.32  ?  360  HIS   C O     1 
ATOM   1661 C CB    . HIS   A 1 360  ? 151.634 115.474 175.852 1.00 50.84  ?  360  HIS   C CB    1 
ATOM   1662 C CG    . HIS   A 1 360  ? 151.801 114.006 176.037 1.00 55.64  ?  360  HIS   C CG    1 
ATOM   1663 N ND1   . HIS   A 1 360  ? 150.787 113.105 175.794 1.00 59.03  ?  360  HIS   C ND1   1 
ATOM   1664 C CD2   . HIS   A 1 360  ? 152.862 113.277 176.446 1.00 54.81  ?  360  HIS   C CD2   1 
ATOM   1665 C CE1   . HIS   A 1 360  ? 151.221 111.883 176.043 1.00 61.94  ?  360  HIS   C CE1   1 
ATOM   1666 N NE2   . HIS   A 1 360  ? 152.476 111.961 176.440 1.00 59.34  ?  360  HIS   C NE2   1 
ATOM   1667 N N     . LEU   A 1 361  ? 151.930 118.145 173.695 1.00 44.00  ?  361  LEU   C N     1 
ATOM   1668 C CA    . LEU   A 1 361  ? 151.773 119.593 173.656 1.00 43.84  ?  361  LEU   C CA    1 
ATOM   1669 C C     . LEU   A 1 361  ? 151.444 120.113 172.262 1.00 45.94  ?  361  LEU   C C     1 
ATOM   1670 O O     . LEU   A 1 361  ? 150.737 121.107 172.113 1.00 49.08  ?  361  LEU   C O     1 
ATOM   1671 C CB    . LEU   A 1 361  ? 153.067 120.256 174.130 1.00 38.92  ?  361  LEU   C CB    1 
ATOM   1672 C CG    . LEU   A 1 361  ? 153.553 119.877 175.530 1.00 41.39  ?  361  LEU   C CG    1 
ATOM   1673 C CD1   . LEU   A 1 361  ? 154.880 120.546 175.785 1.00 41.56  ?  361  LEU   C CD1   1 
ATOM   1674 C CD2   . LEU   A 1 361  ? 152.529 120.302 176.564 1.00 47.88  ?  361  LEU   C CD2   1 
ATOM   1675 N N     . LEU   A 1 362  ? 152.000 119.463 171.250 1.00 43.34  ?  362  LEU   C N     1 
ATOM   1676 C CA    . LEU   A 1 362  ? 151.928 119.950 169.877 1.00 41.15  ?  362  LEU   C CA    1 
ATOM   1677 C C     . LEU   A 1 362  ? 150.532 119.870 169.260 1.00 43.90  ?  362  LEU   C C     1 
ATOM   1678 O O     . LEU   A 1 362  ? 150.151 120.730 168.464 1.00 44.76  ?  362  LEU   C O     1 
ATOM   1679 C CB    . LEU   A 1 362  ? 152.893 119.139 169.016 1.00 40.68  ?  362  LEU   C CB    1 
ATOM   1680 C CG    . LEU   A 1 362  ? 154.390 119.283 169.338 1.00 41.70  ?  362  LEU   C CG    1 
ATOM   1681 C CD1   . LEU   A 1 362  ? 155.162 118.215 168.574 1.00 39.23  ?  362  LEU   C CD1   1 
ATOM   1682 C CD2   . LEU   A 1 362  ? 154.877 120.659 168.952 1.00 39.22  ?  362  LEU   C CD2   1 
ATOM   1683 N N     . ASP   A 1 363  ? 149.794 118.815 169.596 1.00 47.67  ?  363  ASP   C N     1 
ATOM   1684 C CA    . ASP   A 1 363  ? 148.454 118.549 169.060 1.00 53.84  ?  363  ASP   C CA    1 
ATOM   1685 C C     . ASP   A 1 363  ? 148.432 118.303 167.551 1.00 52.63  ?  363  ASP   C C     1 
ATOM   1686 O O     . ASP   A 1 363  ? 148.169 117.185 167.104 1.00 53.04  ?  363  ASP   C O     1 
ATOM   1687 C CB    . ASP   A 1 363  ? 147.483 119.679 169.417 1.00 53.03  ?  363  ASP   C CB    1 
ATOM   1688 C CG    . ASP   A 1 363  ? 147.094 119.673 170.889 1.00 64.03  ?  363  ASP   C CG    1 
ATOM   1689 O OD1   . ASP   A 1 363  ? 147.356 118.695 171.554 1.00 60.45  ?  363  ASP   C OD1   1 
ATOM   1690 O OD2   . ASP   A 1 363  ? 146.524 120.638 171.333 1.00 64.39  -1 363  ASP   C OD2   1 
ATOM   1691 N N     . HIS   A 1 364  ? 148.700 119.343 166.762 1.00 48.00  ?  364  HIS   C N     1 
ATOM   1692 C CA    . HIS   A 1 364  ? 148.666 119.215 165.306 1.00 48.21  ?  364  HIS   C CA    1 
ATOM   1693 C C     . HIS   A 1 364  ? 149.857 119.871 164.611 1.00 41.64  ?  364  HIS   C C     1 
ATOM   1694 O O     . HIS   A 1 364  ? 149.676 120.843 163.877 1.00 38.32  ?  364  HIS   C O     1 
ATOM   1695 C CB    . HIS   A 1 364  ? 147.383 119.835 164.750 1.00 53.01  ?  364  HIS   C CB    1 
ATOM   1696 C CG    . HIS   A 1 364  ? 146.133 119.227 165.285 1.00 62.38  ?  364  HIS   C CG    1 
ATOM   1697 N ND1   . HIS   A 1 364  ? 145.662 118.002 164.866 1.00 63.31  ?  364  HIS   C ND1   1 
ATOM   1698 C CD2   . HIS   A 1 364  ? 145.256 119.674 166.210 1.00 67.07  ?  364  HIS   C CD2   1 
ATOM   1699 C CE1   . HIS   A 1 364  ? 144.544 117.723 165.509 1.00 72.63  ?  364  HIS   C CE1   1 
ATOM   1700 N NE2   . HIS   A 1 364  ? 144.276 118.723 166.330 1.00 71.05  ?  364  HIS   C NE2   1 
ATOM   1701 N N     . PRO   A 1 365  ? 151.075 119.372 164.839 1.00 35.43  ?  365  PRO   C N     1 
ATOM   1702 C CA    . PRO   A 1 365  ? 152.324 119.810 164.251 1.00 25.97  ?  365  PRO   C CA    1 
ATOM   1703 C C     . PRO   A 1 365  ? 152.536 119.257 162.857 1.00 23.37  ?  365  PRO   C C     1 
ATOM   1704 O O     . PRO   A 1 365  ? 152.013 118.201 162.508 1.00 29.00  ?  365  PRO   C O     1 
ATOM   1705 C CB    . PRO   A 1 365  ? 153.349 119.200 165.192 1.00 29.11  ?  365  PRO   C CB    1 
ATOM   1706 C CG    . PRO   A 1 365  ? 152.691 117.912 165.631 1.00 34.75  ?  365  PRO   C CG    1 
ATOM   1707 C CD    . PRO   A 1 365  ? 151.227 118.259 165.776 1.00 40.61  ?  365  PRO   C CD    1 
ATOM   1708 N N     . ARG   A 1 366  ? 153.421 119.907 162.124 1.00 22.67  ?  366  ARG   C N     1 
ATOM   1709 C CA    . ARG   A 1 366  ? 154.027 119.327 160.938 1.00 19.34  ?  366  ARG   C CA    1 
ATOM   1710 C C     . ARG   A 1 366  ? 155.441 118.902 161.299 1.00 20.42  ?  366  ARG   C C     1 
ATOM   1711 O O     . ARG   A 1 366  ? 156.158 119.650 161.962 1.00 23.62  ?  366  ARG   C O     1 
ATOM   1712 C CB    . ARG   A 1 366  ? 154.052 120.334 159.811 1.00 19.80  ?  366  ARG   C CB    1 
ATOM   1713 C CG    . ARG   A 1 366  ? 154.798 119.926 158.572 1.00 19.53  ?  366  ARG   C CG    1 
ATOM   1714 C CD    . ARG   A 1 366  ? 154.692 120.975 157.531 1.00 20.66  ?  366  ARG   C CD    1 
ATOM   1715 N NE    . ARG   A 1 366  ? 153.379 120.991 156.906 1.00 26.93  ?  366  ARG   C NE    1 
ATOM   1716 C CZ    . ARG   A 1 366  ? 152.874 122.012 156.180 1.00 32.54  ?  366  ARG   C CZ    1 
ATOM   1717 N NH1   . ARG   A 1 366  ? 153.554 123.113 155.995 1.00 28.95  1  366  ARG   C NH1   1 
ATOM   1718 N NH2   . ARG   A 1 366  ? 151.675 121.912 155.645 1.00 51.24  ?  366  ARG   C NH2   1 
ATOM   1719 N N     . HIS   A 1 367  ? 155.841 117.701 160.902 1.00 16.30  ?  367  HIS   C N     1 
ATOM   1720 C CA    . HIS   A 1 367  ? 157.173 117.223 161.260 1.00 14.37  ?  367  HIS   C CA    1 
ATOM   1721 C C     . HIS   A 1 367  ? 158.103 117.149 160.070 1.00 16.91  ?  367  HIS   C C     1 
ATOM   1722 O O     . HIS   A 1 367  ? 157.736 116.638 159.010 1.00 23.84  ?  367  HIS   C O     1 
ATOM   1723 C CB    . HIS   A 1 367  ? 157.099 115.852 161.930 1.00 15.87  ?  367  HIS   C CB    1 
ATOM   1724 C CG    . HIS   A 1 367  ? 156.560 115.891 163.308 1.00 18.78  ?  367  HIS   C CG    1 
ATOM   1725 N ND1   . HIS   A 1 367  ? 157.372 116.001 164.414 1.00 19.07  ?  367  HIS   C ND1   1 
ATOM   1726 C CD2   . HIS   A 1 367  ? 155.294 115.834 163.773 1.00 24.80  ?  367  HIS   C CD2   1 
ATOM   1727 C CE1   . HIS   A 1 367  ? 156.629 116.011 165.502 1.00 24.78  ?  367  HIS   C CE1   1 
ATOM   1728 N NE2   . HIS   A 1 367  ? 155.365 115.910 165.143 1.00 25.97  ?  367  HIS   C NE2   1 
ATOM   1729 N N     . VAL   A 1 368  ? 159.302 117.683 160.253 1.00 12.70  ?  368  VAL   C N     1 
ATOM   1730 C CA    . VAL   A 1 368  ? 160.329 117.655 159.228 1.00 9.72   ?  368  VAL   C CA    1 
ATOM   1731 C C     . VAL   A 1 368  ? 161.642 117.141 159.803 1.00 13.37  ?  368  VAL   C C     1 
ATOM   1732 O O     . VAL   A 1 368  ? 162.100 117.615 160.842 1.00 16.38  ?  368  VAL   C O     1 
ATOM   1733 C CB    . VAL   A 1 368  ? 160.519 119.058 158.628 1.00 11.56  ?  368  VAL   C CB    1 
ATOM   1734 C CG1   . VAL   A 1 368  ? 161.607 119.035 157.578 1.00 19.13  ?  368  VAL   C CG1   1 
ATOM   1735 C CG2   . VAL   A 1 368  ? 159.209 119.535 158.012 1.00 14.62  ?  368  VAL   C CG2   1 
ATOM   1736 N N     . GLU   A 1 369  ? 162.236 116.161 159.142 1.00 16.73  ?  369  GLU   C N     1 
ATOM   1737 C CA    . GLU   A 1 369  ? 163.492 115.596 159.614 1.00 16.08  ?  369  GLU   C CA    1 
ATOM   1738 C C     . GLU   A 1 369  ? 164.673 116.227 158.900 1.00 19.64  ?  369  GLU   C C     1 
ATOM   1739 O O     . GLU   A 1 369  ? 164.617 116.492 157.698 1.00 24.09  ?  369  GLU   C O     1 
ATOM   1740 C CB    . GLU   A 1 369  ? 163.519 114.078 159.436 1.00 21.16  ?  369  GLU   C CB    1 
ATOM   1741 C CG    . GLU   A 1 369  ? 164.780 113.415 159.990 1.00 26.67  ?  369  GLU   C CG    1 
ATOM   1742 C CD    . GLU   A 1 369  ? 164.753 111.917 159.933 1.00 37.93  ?  369  GLU   C CD    1 
ATOM   1743 O OE1   . GLU   A 1 369  ? 164.581 111.379 158.866 1.00 42.08  ?  369  GLU   C OE1   1 
ATOM   1744 O OE2   . GLU   A 1 369  ? 164.909 111.307 160.965 1.00 31.49  -1 369  GLU   C OE2   1 
ATOM   1745 N N     . ILE   A 1 370  ? 165.739 116.472 159.647 1.00 18.11  ?  370  ILE   C N     1 
ATOM   1746 C CA    . ILE   A 1 370  ? 166.949 117.042 159.078 1.00 17.54  ?  370  ILE   C CA    1 
ATOM   1747 C C     . ILE   A 1 370  ? 167.967 115.966 158.756 1.00 23.23  ?  370  ILE   C C     1 
ATOM   1748 O O     . ILE   A 1 370  ? 168.345 115.172 159.616 1.00 27.73  ?  370  ILE   C O     1 
ATOM   1749 C CB    . ILE   A 1 370  ? 167.567 118.070 160.037 1.00 15.22  ?  370  ILE   C CB    1 
ATOM   1750 C CG1   . ILE   A 1 370  ? 166.582 119.217 160.243 1.00 15.47  ?  370  ILE   C CG1   1 
ATOM   1751 C CG2   . ILE   A 1 370  ? 168.896 118.582 159.483 1.00 23.88  ?  370  ILE   C CG2   1 
ATOM   1752 C CD1   . ILE   A 1 370  ? 166.934 120.128 161.379 1.00 19.17  ?  370  ILE   C CD1   1 
ATOM   1753 N N     . LEU   A 1 371  ? 168.415 115.948 157.510 1.00 24.76  ?  371  LEU   C N     1 
ATOM   1754 C CA    . LEU   A 1 371  ? 169.424 114.999 157.077 1.00 23.93  ?  371  LEU   C CA    1 
ATOM   1755 C C     . LEU   A 1 371  ? 170.792 115.653 157.105 1.00 27.23  ?  371  LEU   C C     1 
ATOM   1756 O O     . LEU   A 1 371  ? 170.903 116.878 157.127 1.00 29.46  ?  371  LEU   C O     1 
ATOM   1757 C CB    . LEU   A 1 371  ? 169.137 114.504 155.663 1.00 28.99  ?  371  LEU   C CB    1 
ATOM   1758 C CG    . LEU   A 1 371  ? 167.764 113.873 155.418 1.00 36.60  ?  371  LEU   C CG    1 
ATOM   1759 C CD1   . LEU   A 1 371  ? 167.665 113.499 153.945 1.00 43.13  ?  371  LEU   C CD1   1 
ATOM   1760 C CD2   . LEU   A 1 371  ? 167.580 112.647 156.308 1.00 39.51  ?  371  LEU   C CD2   1 
ATOM   1761 N N     . GLY   A 1 372  ? 171.832 114.833 157.107 1.00 29.33  ?  372  GLY   C N     1 
ATOM   1762 C CA    . GLY   A 1 372  ? 173.197 115.337 157.152 1.00 30.62  ?  372  GLY   C CA    1 
ATOM   1763 C C     . GLY   A 1 372  ? 173.734 115.599 155.757 1.00 31.65  ?  372  GLY   C C     1 
ATOM   1764 O O     . GLY   A 1 372  ? 172.974 115.834 154.817 1.00 34.60  ?  372  GLY   C O     1 
ATOM   1765 N N     . PHE   A 1 373  ? 175.049 115.601 155.630 1.00 31.70  ?  373  PHE   C N     1 
ATOM   1766 C CA    . PHE   A 1 373  ? 175.672 115.955 154.369 1.00 33.63  ?  373  PHE   C CA    1 
ATOM   1767 C C     . PHE   A 1 373  ? 175.695 114.795 153.390 1.00 38.69  ?  373  PHE   C C     1 
ATOM   1768 O O     . PHE   A 1 373  ? 175.971 113.654 153.762 1.00 42.29  ?  373  PHE   C O     1 
ATOM   1769 C CB    . PHE   A 1 373  ? 177.106 116.417 154.606 1.00 37.52  ?  373  PHE   C CB    1 
ATOM   1770 C CG    . PHE   A 1 373  ? 177.261 117.706 155.371 1.00 31.38  ?  373  PHE   C CG    1 
ATOM   1771 C CD1   . PHE   A 1 373  ? 176.227 118.624 155.492 1.00 29.74  ?  373  PHE   C CD1   1 
ATOM   1772 C CD2   . PHE   A 1 373  ? 178.474 118.000 155.974 1.00 31.91  ?  373  PHE   C CD2   1 
ATOM   1773 C CE1   . PHE   A 1 373  ? 176.412 119.788 156.191 1.00 34.53  ?  373  PHE   C CE1   1 
ATOM   1774 C CE2   . PHE   A 1 373  ? 178.652 119.165 156.671 1.00 31.57  ?  373  PHE   C CE2   1 
ATOM   1775 C CZ    . PHE   A 1 373  ? 177.624 120.058 156.781 1.00 38.79  ?  373  PHE   C CZ    1 
ATOM   1776 N N     . SER   A 1 374  ? 175.462 115.105 152.122 1.00 39.93  ?  374  SER   C N     1 
ATOM   1777 C CA    . SER   A 1 374  ? 175.638 114.138 151.052 1.00 44.19  ?  374  SER   C CA    1 
ATOM   1778 C C     . SER   A 1 374  ? 177.120 114.051 150.727 1.00 46.90  ?  374  SER   C C     1 
ATOM   1779 O O     . SER   A 1 374  ? 177.901 114.887 151.179 1.00 46.27  ?  374  SER   C O     1 
ATOM   1780 C CB    . SER   A 1 374  ? 174.863 114.554 149.820 1.00 47.08  ?  374  SER   C CB    1 
ATOM   1781 O OG    . SER   A 1 374  ? 175.455 115.669 149.209 1.00 46.41  ?  374  SER   C OG    1 
ATOM   1782 N N     . GLU   A 1 375  ? 177.518 113.060 149.942 1.00 47.58  ?  375  GLU   C N     1 
ATOM   1783 C CA    . GLU   A 1 375  ? 178.930 112.922 149.605 1.00 50.31  ?  375  GLU   C CA    1 
ATOM   1784 C C     . GLU   A 1 375  ? 179.485 114.187 148.960 1.00 48.34  ?  375  GLU   C C     1 
ATOM   1785 O O     . GLU   A 1 375  ? 180.575 114.646 149.309 1.00 49.92  ?  375  GLU   C O     1 
ATOM   1786 C CB    . GLU   A 1 375  ? 179.131 111.729 148.675 1.00 54.15  ?  375  GLU   C CB    1 
ATOM   1787 C CG    . GLU   A 1 375  ? 180.576 111.465 148.293 1.00 58.10  ?  375  GLU   C CG    1 
ATOM   1788 C CD    . GLU   A 1 375  ? 180.728 110.244 147.439 1.00 69.77  ?  375  GLU   C CD    1 
ATOM   1789 O OE1   . GLU   A 1 375  ? 179.744 109.591 147.194 1.00 65.52  ?  375  GLU   C OE1   1 
ATOM   1790 O OE2   . GLU   A 1 375  ? 181.828 109.963 147.027 1.00 74.18  -1 375  GLU   C OE2   1 
ATOM   1791 N N     . ALA   A 1 376  ? 178.730 114.757 148.027 1.00 45.18  ?  376  ALA   C N     1 
ATOM   1792 C CA    . ALA   A 1 376  ? 179.160 115.974 147.357 1.00 45.56  ?  376  ALA   C CA    1 
ATOM   1793 C C     . ALA   A 1 376  ? 179.239 117.131 148.341 1.00 47.65  ?  376  ALA   C C     1 
ATOM   1794 O O     . ALA   A 1 376  ? 180.146 117.962 148.266 1.00 51.45  ?  376  ALA   C O     1 
ATOM   1795 C CB    . ALA   A 1 376  ? 178.207 116.314 146.225 1.00 47.26  ?  376  ALA   C CB    1 
ATOM   1796 N N     . LYS   A 1 377  ? 178.290 117.187 149.268 1.00 43.86  ?  377  LYS   C N     1 
ATOM   1797 C CA    . LYS   A 1 377  ? 178.269 118.270 150.238 1.00 42.97  ?  377  LYS   C CA    1 
ATOM   1798 C C     . LYS   A 1 377  ? 179.420 118.145 151.222 1.00 40.33  ?  377  LYS   C C     1 
ATOM   1799 O O     . LYS   A 1 377  ? 179.981 119.154 151.652 1.00 43.19  ?  377  LYS   C O     1 
ATOM   1800 C CB    . LYS   A 1 377  ? 176.928 118.323 150.962 1.00 44.10  ?  377  LYS   C CB    1 
ATOM   1801 C CG    . LYS   A 1 377  ? 175.753 118.793 150.082 1.00 44.23  ?  377  LYS   C CG    1 
ATOM   1802 C CD    . LYS   A 1 377  ? 175.796 120.311 149.833 1.00 43.23  ?  377  LYS   C CD    1 
ATOM   1803 C CE    . LYS   A 1 377  ? 174.666 120.777 148.913 1.00 49.49  ?  377  LYS   C CE    1 
ATOM   1804 N NZ    . LYS   A 1 377  ? 174.928 120.443 147.479 1.00 51.72  1  377  LYS   C NZ    1 
ATOM   1805 N N     . ARG   A 1 378  ? 179.798 116.916 151.561 1.00 40.62  ?  378  ARG   C N     1 
ATOM   1806 C CA    . ARG   A 1 378  ? 180.935 116.733 152.445 1.00 40.55  ?  378  ARG   C CA    1 
ATOM   1807 C C     . ARG   A 1 378  ? 182.180 117.307 151.796 1.00 44.21  ?  378  ARG   C C     1 
ATOM   1808 O O     . ARG   A 1 378  ? 182.944 118.024 152.442 1.00 45.71  ?  378  ARG   C O     1 
ATOM   1809 C CB    . ARG   A 1 378  ? 181.145 115.264 152.795 1.00 40.93  ?  378  ARG   C CB    1 
ATOM   1810 C CG    . ARG   A 1 378  ? 180.145 114.721 153.798 1.00 42.21  ?  378  ARG   C CG    1 
ATOM   1811 C CD    . ARG   A 1 378  ? 180.530 113.397 154.358 1.00 44.98  ?  378  ARG   C CD    1 
ATOM   1812 N NE    . ARG   A 1 378  ? 180.411 112.312 153.395 1.00 45.87  ?  378  ARG   C NE    1 
ATOM   1813 C CZ    . ARG   A 1 378  ? 179.262 111.664 153.107 1.00 47.13  ?  378  ARG   C CZ    1 
ATOM   1814 N NH1   . ARG   A 1 378  ? 178.142 112.030 153.683 1.00 43.51  1  378  ARG   C NH1   1 
ATOM   1815 N NH2   . ARG   A 1 378  ? 179.264 110.663 152.244 1.00 50.69  ?  378  ARG   C NH2   1 
ATOM   1816 N N     . LYS   A 1 379  ? 182.358 117.048 150.504 1.00 47.35  ?  379  LYS   C N     1 
ATOM   1817 C CA    . LYS   A 1 379  ? 183.502 117.609 149.804 1.00 50.99  ?  379  LYS   C CA    1 
ATOM   1818 C C     . LYS   A 1 379  ? 183.506 119.125 149.910 1.00 48.77  ?  379  LYS   C C     1 
ATOM   1819 O O     . LYS   A 1 379  ? 184.535 119.723 150.227 1.00 49.93  ?  379  LYS   C O     1 
ATOM   1820 C CB    . LYS   A 1 379  ? 183.503 117.190 148.333 1.00 54.02  ?  379  LYS   C CB    1 
ATOM   1821 C CG    . LYS   A 1 379  ? 183.885 115.747 148.097 1.00 55.08  ?  379  LYS   C CG    1 
ATOM   1822 C CD    . LYS   A 1 379  ? 183.794 115.372 146.627 1.00 59.61  ?  379  LYS   C CD    1 
ATOM   1823 C CE    . LYS   A 1 379  ? 184.157 113.908 146.411 1.00 59.96  ?  379  LYS   C CE    1 
ATOM   1824 N NZ    . LYS   A 1 379  ? 184.056 113.514 144.976 1.00 66.50  1  379  LYS   C NZ    1 
ATOM   1825 N N     . GLU   A 1 380  ? 182.348 119.746 149.693 1.00 46.87  ?  380  GLU   C N     1 
ATOM   1826 C CA    . GLU   A 1 380  ? 182.278 121.199 149.751 1.00 50.83  ?  380  GLU   C CA    1 
ATOM   1827 C C     . GLU   A 1 380  ? 182.667 121.715 151.122 1.00 48.96  ?  380  GLU   C C     1 
ATOM   1828 O O     . GLU   A 1 380  ? 183.426 122.678 151.233 1.00 50.77  ?  380  GLU   C O     1 
ATOM   1829 C CB    . GLU   A 1 380  ? 180.868 121.696 149.427 1.00 54.63  ?  380  GLU   C CB    1 
ATOM   1830 C CG    . GLU   A 1 380  ? 180.432 121.508 147.986 1.00 58.40  ?  380  GLU   C CG    1 
ATOM   1831 C CD    . GLU   A 1 380  ? 179.042 122.042 147.734 1.00 62.04  ?  380  GLU   C CD    1 
ATOM   1832 O OE1   . GLU   A 1 380  ? 178.468 122.589 148.648 1.00 59.06  ?  380  GLU   C OE1   1 
ATOM   1833 O OE2   . GLU   A 1 380  ? 178.552 121.895 146.637 1.00 56.89  -1 380  GLU   C OE2   1 
ATOM   1834 N N     . TYR   A 1 381  ? 182.172 121.064 152.167 1.00 43.99  ?  381  TYR   C N     1 
ATOM   1835 C CA    . TYR   A 1 381  ? 182.493 121.497 153.514 1.00 41.49  ?  381  TYR   C CA    1 
ATOM   1836 C C     . TYR   A 1 381  ? 183.991 121.459 153.747 1.00 40.39  ?  381  TYR   C C     1 
ATOM   1837 O O     . TYR   A 1 381  ? 184.572 122.418 154.262 1.00 46.66  ?  381  TYR   C O     1 
ATOM   1838 C CB    . TYR   A 1 381  ? 181.791 120.640 154.559 1.00 40.21  ?  381  TYR   C CB    1 
ATOM   1839 C CG    . TYR   A 1 381  ? 182.114 121.090 155.951 1.00 32.64  ?  381  TYR   C CG    1 
ATOM   1840 C CD1   . TYR   A 1 381  ? 181.340 122.061 156.546 1.00 31.19  ?  381  TYR   C CD1   1 
ATOM   1841 C CD2   . TYR   A 1 381  ? 183.203 120.560 156.622 1.00 36.15  ?  381  TYR   C CD2   1 
ATOM   1842 C CE1   . TYR   A 1 381  ? 181.643 122.502 157.809 1.00 32.33  ?  381  TYR   C CE1   1 
ATOM   1843 C CE2   . TYR   A 1 381  ? 183.507 121.004 157.886 1.00 34.89  ?  381  TYR   C CE2   1 
ATOM   1844 C CZ    . TYR   A 1 381  ? 182.731 121.971 158.477 1.00 33.64  ?  381  TYR   C CZ    1 
ATOM   1845 O OH    . TYR   A 1 381  ? 183.031 122.413 159.735 1.00 40.01  ?  381  TYR   C OH    1 
ATOM   1846 N N     . PHE   A 1 382  ? 184.621 120.348 153.383 1.00 39.13  ?  382  PHE   C N     1 
ATOM   1847 C CA    . PHE   A 1 382  ? 186.044 120.205 153.626 1.00 41.72  ?  382  PHE   C CA    1 
ATOM   1848 C C     . PHE   A 1 382  ? 186.831 121.283 152.899 1.00 48.97  ?  382  PHE   C C     1 
ATOM   1849 O O     . PHE   A 1 382  ? 187.752 121.867 153.467 1.00 50.64  ?  382  PHE   C O     1 
ATOM   1850 C CB    . PHE   A 1 382  ? 186.531 118.816 153.204 1.00 45.60  ?  382  PHE   C CB    1 
ATOM   1851 C CG    . PHE   A 1 382  ? 186.163 117.733 154.186 1.00 43.50  ?  382  PHE   C CG    1 
ATOM   1852 C CD1   . PHE   A 1 382  ? 185.214 116.769 153.878 1.00 47.52  ?  382  PHE   C CD1   1 
ATOM   1853 C CD2   . PHE   A 1 382  ? 186.759 117.684 155.423 1.00 36.95  ?  382  PHE   C CD2   1 
ATOM   1854 C CE1   . PHE   A 1 382  ? 184.872 115.794 154.786 1.00 48.77  ?  382  PHE   C CE1   1 
ATOM   1855 C CE2   . PHE   A 1 382  ? 186.417 116.713 156.334 1.00 42.32  ?  382  PHE   C CE2   1 
ATOM   1856 C CZ    . PHE   A 1 382  ? 185.471 115.767 156.015 1.00 47.54  ?  382  PHE   C CZ    1 
ATOM   1857 N N     . PHE   A 1 383  ? 186.459 121.583 151.658 1.00 50.29  ?  383  PHE   C N     1 
ATOM   1858 C CA    . PHE   A 1 383  ? 187.171 122.613 150.913 1.00 51.87  ?  383  PHE   C CA    1 
ATOM   1859 C C     . PHE   A 1 383  ? 186.953 123.999 151.497 1.00 51.57  ?  383  PHE   C C     1 
ATOM   1860 O O     . PHE   A 1 383  ? 187.894 124.782 151.610 1.00 52.81  ?  383  PHE   C O     1 
ATOM   1861 C CB    . PHE   A 1 383  ? 186.757 122.605 149.442 1.00 49.91  ?  383  PHE   C CB    1 
ATOM   1862 C CG    . PHE   A 1 383  ? 187.431 121.531 148.652 1.00 51.41  ?  383  PHE   C CG    1 
ATOM   1863 C CD1   . PHE   A 1 383  ? 186.721 120.452 148.164 1.00 54.87  ?  383  PHE   C CD1   1 
ATOM   1864 C CD2   . PHE   A 1 383  ? 188.789 121.597 148.405 1.00 56.68  ?  383  PHE   C CD2   1 
ATOM   1865 C CE1   . PHE   A 1 383  ? 187.353 119.460 147.450 1.00 57.73  ?  383  PHE   C CE1   1 
ATOM   1866 C CE2   . PHE   A 1 383  ? 189.426 120.614 147.695 1.00 63.25  ?  383  PHE   C CE2   1 
ATOM   1867 C CZ    . PHE   A 1 383  ? 188.708 119.539 147.215 1.00 64.58  ?  383  PHE   C CZ    1 
ATOM   1868 N N     . LYS   A 1 384  ? 185.724 124.305 151.891 1.00 48.66  ?  384  LYS   C N     1 
ATOM   1869 C CA    . LYS   A 1 384  ? 185.423 125.619 152.445 1.00 45.20  ?  384  LYS   C CA    1 
ATOM   1870 C C     . LYS   A 1 384  ? 186.176 125.868 153.748 1.00 45.58  ?  384  LYS   C C     1 
ATOM   1871 O O     . LYS   A 1 384  ? 186.501 127.008 154.075 1.00 52.89  ?  384  LYS   C O     1 
ATOM   1872 C CB    . LYS   A 1 384  ? 183.919 125.782 152.651 1.00 45.85  ?  384  LYS   C CB    1 
ATOM   1873 C CG    . LYS   A 1 384  ? 183.132 125.935 151.350 1.00 50.08  ?  384  LYS   C CG    1 
ATOM   1874 C CD    . LYS   A 1 384  ? 181.639 126.038 151.603 1.00 56.08  ?  384  LYS   C CD    1 
ATOM   1875 C CE    . LYS   A 1 384  ? 180.863 126.134 150.299 1.00 59.66  ?  384  LYS   C CE    1 
ATOM   1876 N NZ    . LYS   A 1 384  ? 179.396 126.222 150.533 1.00 57.55  1  384  LYS   C NZ    1 
ATOM   1877 N N     . TYR   A 1 385  ? 186.454 124.800 154.486 1.00 47.52  ?  385  TYR   C N     1 
ATOM   1878 C CA    . TYR   A 1 385  ? 187.168 124.895 155.752 1.00 49.95  ?  385  TYR   C CA    1 
ATOM   1879 C C     . TYR   A 1 385  ? 188.612 125.378 155.610 1.00 51.91  ?  385  TYR   C C     1 
ATOM   1880 O O     . TYR   A 1 385  ? 189.190 125.881 156.573 1.00 56.24  ?  385  TYR   C O     1 
ATOM   1881 C CB    . TYR   A 1 385  ? 187.162 123.545 156.467 1.00 53.30  ?  385  TYR   C CB    1 
ATOM   1882 C CG    . TYR   A 1 385  ? 187.607 123.626 157.907 1.00 48.82  ?  385  TYR   C CG    1 
ATOM   1883 C CD1   . TYR   A 1 385  ? 186.700 123.979 158.891 1.00 42.51  ?  385  TYR   C CD1   1 
ATOM   1884 C CD2   . TYR   A 1 385  ? 188.920 123.356 158.242 1.00 53.86  ?  385  TYR   C CD2   1 
ATOM   1885 C CE1   . TYR   A 1 385  ? 187.109 124.055 160.204 1.00 47.26  ?  385  TYR   C CE1   1 
ATOM   1886 C CE2   . TYR   A 1 385  ? 189.328 123.433 159.550 1.00 54.78  ?  385  TYR   C CE2   1 
ATOM   1887 C CZ    . TYR   A 1 385  ? 188.430 123.779 160.531 1.00 51.42  ?  385  TYR   C CZ    1 
ATOM   1888 O OH    . TYR   A 1 385  ? 188.842 123.853 161.838 1.00 58.09  ?  385  TYR   C OH    1 
ATOM   1889 N N     . PHE   A 1 386  ? 189.225 125.180 154.444 1.00 51.23  ?  386  PHE   C N     1 
ATOM   1890 C CA    . PHE   A 1 386  ? 190.637 125.523 154.289 1.00 58.59  ?  386  PHE   C CA    1 
ATOM   1891 C C     . PHE   A 1 386  ? 190.864 126.629 153.265 1.00 62.73  ?  386  PHE   C C     1 
ATOM   1892 O O     . PHE   A 1 386  ? 190.181 126.700 152.246 1.00 59.70  ?  386  PHE   C O     1 
ATOM   1893 C CB    . PHE   A 1 386  ? 191.448 124.298 153.872 1.00 60.82  ?  386  PHE   C CB    1 
ATOM   1894 C CG    . PHE   A 1 386  ? 191.502 123.204 154.895 1.00 56.62  ?  386  PHE   C CG    1 
ATOM   1895 C CD1   . PHE   A 1 386  ? 190.612 122.154 154.839 1.00 53.97  ?  386  PHE   C CD1   1 
ATOM   1896 C CD2   . PHE   A 1 386  ? 192.444 123.222 155.913 1.00 62.44  ?  386  PHE   C CD2   1 
ATOM   1897 C CE1   . PHE   A 1 386  ? 190.652 121.138 155.765 1.00 59.43  ?  386  PHE   C CE1   1 
ATOM   1898 C CE2   . PHE   A 1 386  ? 192.491 122.208 156.846 1.00 63.68  ?  386  PHE   C CE2   1 
ATOM   1899 C CZ    . PHE   A 1 386  ? 191.591 121.164 156.774 1.00 64.26  ?  386  PHE   C CZ    1 
ATOM   1900 N N     . SER   A 1 387  ? 191.869 127.464 153.514 1.00 65.85  ?  387  SER   C N     1 
ATOM   1901 C CA    . SER   A 1 387  ? 192.246 128.502 152.561 1.00 69.85  ?  387  SER   C CA    1 
ATOM   1902 C C     . SER   A 1 387  ? 193.112 127.936 151.441 1.00 69.36  ?  387  SER   C C     1 
ATOM   1903 O O     . SER   A 1 387  ? 193.203 128.510 150.357 1.00 69.81  ?  387  SER   C O     1 
ATOM   1904 C CB    . SER   A 1 387  ? 192.996 129.606 153.276 1.00 74.41  ?  387  SER   C CB    1 
ATOM   1905 O OG    . SER   A 1 387  ? 194.220 129.136 153.770 1.00 70.17  ?  387  SER   C OG    1 
ATOM   1906 N N     . ASP   A 1 388  ? 193.749 126.803 151.718 1.00 67.10  ?  388  ASP   C N     1 
ATOM   1907 C CA    . ASP   A 1 388  ? 194.628 126.143 150.767 1.00 69.39  ?  388  ASP   C CA    1 
ATOM   1908 C C     . ASP   A 1 388  ? 193.985 124.886 150.210 1.00 67.72  ?  388  ASP   C C     1 
ATOM   1909 O O     . ASP   A 1 388  ? 193.691 123.948 150.956 1.00 68.62  ?  388  ASP   C O     1 
ATOM   1910 C CB    . ASP   A 1 388  ? 195.971 125.786 151.398 1.00 68.90  ?  388  ASP   C CB    1 
ATOM   1911 C CG    . ASP   A 1 388  ? 196.932 125.152 150.383 1.00 71.20  ?  388  ASP   C CG    1 
ATOM   1912 O OD1   . ASP   A 1 388  ? 196.533 124.987 149.245 1.00 69.64  ?  388  ASP   C OD1   1 
ATOM   1913 O OD2   . ASP   A 1 388  ? 198.044 124.847 150.743 1.00 72.11  -1 388  ASP   C OD2   1 
ATOM   1914 N N     . GLU   A 1 389  ? 193.724 124.882 148.910 1.00 68.24  ?  389  GLU   C N     1 
ATOM   1915 C CA    . GLU   A 1 389  ? 193.070 123.745 148.290 1.00 69.73  ?  389  GLU   C CA    1 
ATOM   1916 C C     . GLU   A 1 389  ? 193.911 122.486 148.443 1.00 69.34  ?  389  GLU   C C     1 
ATOM   1917 O O     . GLU   A 1 389  ? 193.369 121.385 148.555 1.00 69.47  ?  389  GLU   C O     1 
ATOM   1918 C CB    . GLU   A 1 389  ? 192.815 124.001 146.808 1.00 71.85  ?  389  GLU   C CB    1 
ATOM   1919 C CG    . GLU   A 1 389  ? 191.783 125.057 146.502 1.00 73.04  ?  389  GLU   C CG    1 
ATOM   1920 C CD    . GLU   A 1 389  ? 191.580 125.228 145.022 1.00 84.20  ?  389  GLU   C CD    1 
ATOM   1921 O OE1   . GLU   A 1 389  ? 192.223 124.527 144.264 1.00 81.50  ?  389  GLU   C OE1   1 
ATOM   1922 O OE2   . GLU   A 1 389  ? 190.783 126.051 144.644 1.00 82.42  -1 389  GLU   C OE2   1 
ATOM   1923 N N     . ALA   A 1 390  ? 195.235 122.635 148.425 1.00 68.61  ?  390  ALA   C N     1 
ATOM   1924 C CA    . ALA   A 1 390  ? 196.120 121.486 148.533 1.00 69.13  ?  390  ALA   C CA    1 
ATOM   1925 C C     . ALA   A 1 390  ? 195.938 120.795 149.875 1.00 73.44  ?  390  ALA   C C     1 
ATOM   1926 O O     . ALA   A 1 390  ? 196.033 119.574 149.973 1.00 70.51  ?  390  ALA   C O     1 
ATOM   1927 C CB    . ALA   A 1 390  ? 197.567 121.905 148.355 1.00 68.20  ?  390  ALA   C CB    1 
ATOM   1928 N N     . GLN   A 1 391  ? 195.694 121.594 150.912 1.00 69.45  ?  391  GLN   C N     1 
ATOM   1929 C CA    . GLN   A 1 391  ? 195.513 121.049 152.249 1.00 70.03  ?  391  GLN   C CA    1 
ATOM   1930 C C     . GLN   A 1 391  ? 194.165 120.372 152.351 1.00 65.41  ?  391  GLN   C C     1 
ATOM   1931 O O     . GLN   A 1 391  ? 194.046 119.297 152.949 1.00 65.77  ?  391  GLN   C O     1 
ATOM   1932 C CB    . GLN   A 1 391  ? 195.632 122.161 153.290 1.00 70.49  ?  391  GLN   C CB    1 
ATOM   1933 C CG    . GLN   A 1 391  ? 197.034 122.731 153.408 1.00 76.14  ?  391  GLN   C CG    1 
ATOM   1934 C CD    . GLN   A 1 391  ? 197.116 123.897 154.370 1.00 79.60  ?  391  GLN   C CD    1 
ATOM   1935 O OE1   . GLN   A 1 391  ? 196.109 124.537 154.687 1.00 74.25  ?  391  GLN   C OE1   1 
ATOM   1936 N NE2   . GLN   A 1 391  ? 198.323 124.190 154.839 1.00 84.19  ?  391  GLN   C NE2   1 
ATOM   1937 N N     . ALA   A 1 392  ? 193.150 120.976 151.742 1.00 65.13  ?  392  ALA   C N     1 
ATOM   1938 C CA    . ALA   A 1 392  ? 191.821 120.396 151.740 1.00 63.73  ?  392  ALA   C CA    1 
ATOM   1939 C C     . ALA   A 1 392  ? 191.829 119.057 151.023 1.00 62.83  ?  392  ALA   C C     1 
ATOM   1940 O O     . ALA   A 1 392  ? 191.173 118.111 151.449 1.00 63.03  ?  392  ALA   C O     1 
ATOM   1941 C CB    . ALA   A 1 392  ? 190.828 121.323 151.079 1.00 59.48  ?  392  ALA   C CB    1 
ATOM   1942 N N     . ARG   A 1 393  ? 192.580 118.980 149.926 1.00 64.22  ?  393  ARG   C N     1 
ATOM   1943 C CA    . ARG   A 1 393  ? 192.662 117.745 149.168 1.00 66.71  ?  393  ARG   C CA    1 
ATOM   1944 C C     . ARG   A 1 393  ? 193.372 116.652 149.959 1.00 66.24  ?  393  ARG   C C     1 
ATOM   1945 O O     . ARG   A 1 393  ? 192.925 115.510 149.983 1.00 66.02  ?  393  ARG   C O     1 
ATOM   1946 C CB    . ARG   A 1 393  ? 193.363 117.969 147.837 1.00 70.65  ?  393  ARG   C CB    1 
ATOM   1947 C CG    . ARG   A 1 393  ? 192.523 118.698 146.792 1.00 72.92  ?  393  ARG   C CG    1 
ATOM   1948 C CD    . ARG   A 1 393  ? 193.133 118.638 145.438 1.00 76.75  ?  393  ARG   C CD    1 
ATOM   1949 N NE    . ARG   A 1 393  ? 194.334 119.460 145.339 1.00 78.53  ?  393  ARG   C NE    1 
ATOM   1950 C CZ    . ARG   A 1 393  ? 194.352 120.760 144.965 1.00 78.52  ?  393  ARG   C CZ    1 
ATOM   1951 N NH1   . ARG   A 1 393  ? 193.230 121.373 144.645 1.00 73.09  1  393  ARG   C NH1   1 
ATOM   1952 N NH2   . ARG   A 1 393  ? 195.500 121.414 144.918 1.00 79.60  ?  393  ARG   C NH2   1 
ATOM   1953 N N     . ALA   A 1 394  ? 194.469 117.019 150.627 1.00 64.93  ?  394  ALA   C N     1 
ATOM   1954 C CA    . ALA   A 1 394  ? 195.199 116.031 151.426 1.00 67.86  ?  394  ALA   C CA    1 
ATOM   1955 C C     . ALA   A 1 394  ? 194.330 115.530 152.564 1.00 65.88  ?  394  ALA   C C     1 
ATOM   1956 O O     . ALA   A 1 394  ? 194.323 114.316 152.855 1.00 64.96  ?  394  ALA   C O     1 
ATOM   1957 C CB    . ALA   A 1 394  ? 196.461 116.668 151.997 1.00 69.35  ?  394  ALA   C CB    1 
ATOM   1958 N N     . ALA   A 1 395  ? 193.601 116.421 153.211 1.00 63.94  ?  395  ALA   C N     1 
ATOM   1959 C CA    . ALA   A 1 395  ? 192.758 116.064 154.327 1.00 62.01  ?  395  ALA   C CA    1 
ATOM   1960 C C     . ALA   A 1 395  ? 191.572 115.228 153.871 1.00 57.53  ?  395  ALA   C C     1 
ATOM   1961 O O     . ALA   A 1 395  ? 191.230 114.228 154.486 1.00 60.00  ?  395  ALA   C O     1 
ATOM   1962 C CB    . ALA   A 1 395  ? 192.284 117.302 155.058 1.00 64.75  ?  395  ALA   C CB    1 
ATOM   1963 N N     . PHE   A 1 396  ? 190.968 115.637 152.754 1.00 54.04  ?  396  PHE   C N     1 
ATOM   1964 C CA    . PHE   A 1 396  ? 189.824 114.901 152.256 1.00 51.57  ?  396  PHE   C CA    1 
ATOM   1965 C C     . PHE   A 1 396  ? 190.229 113.490 151.908 1.00 56.72  ?  396  PHE   C C     1 
ATOM   1966 O O     . PHE   A 1 396  ? 189.532 112.536 152.261 1.00 58.52  ?  396  PHE   C O     1 
ATOM   1967 C CB    . PHE   A 1 396  ? 189.223 115.559 151.023 1.00 51.87  ?  396  PHE   C CB    1 
ATOM   1968 C CG    . PHE   A 1 396  ? 188.001 114.834 150.581 1.00 48.46  ?  396  PHE   C CG    1 
ATOM   1969 C CD1   . PHE   A 1 396  ? 186.787 115.123 151.160 1.00 48.47  ?  396  PHE   C CD1   1 
ATOM   1970 C CD2   . PHE   A 1 396  ? 188.060 113.838 149.620 1.00 55.00  ?  396  PHE   C CD2   1 
ATOM   1971 C CE1   . PHE   A 1 396  ? 185.653 114.446 150.795 1.00 50.36  ?  396  PHE   C CE1   1 
ATOM   1972 C CE2   . PHE   A 1 396  ? 186.925 113.154 149.252 1.00 57.75  ?  396  PHE   C CE2   1 
ATOM   1973 C CZ    . PHE   A 1 396  ? 185.720 113.457 149.843 1.00 54.65  ?  396  PHE   C CZ    1 
ATOM   1974 N N     . SER   A 1 397  ? 191.347 113.349 151.205 1.00 57.86  ?  397  SER   C N     1 
ATOM   1975 C CA    . SER   A 1 397  ? 191.819 112.046 150.772 1.00 62.17  ?  397  SER   C CA    1 
ATOM   1976 C C     . SER   A 1 397  ? 192.048 111.124 151.959 1.00 64.23  ?  397  SER   C C     1 
ATOM   1977 O O     . SER   A 1 397  ? 191.618 109.971 151.948 1.00 64.07  ?  397  SER   C O     1 
ATOM   1978 C CB    . SER   A 1 397  ? 193.099 112.199 149.979 1.00 64.68  ?  397  SER   C CB    1 
ATOM   1979 O OG    . SER   A 1 397  ? 193.594 110.955 149.575 1.00 69.32  ?  397  SER   C OG    1 
ATOM   1980 N N     . LEU   A 1 398  ? 192.686 111.641 153.003 1.00 62.17  ?  398  LEU   C N     1 
ATOM   1981 C CA    . LEU   A 1 398  ? 192.925 110.844 154.199 1.00 61.92  ?  398  LEU   C CA    1 
ATOM   1982 C C     . LEU   A 1 398  ? 191.618 110.326 154.784 1.00 59.87  ?  398  LEU   C C     1 
ATOM   1983 O O     . LEU   A 1 398  ? 191.491 109.142 155.114 1.00 61.61  ?  398  LEU   C O     1 
ATOM   1984 C CB    . LEU   A 1 398  ? 193.646 111.691 155.250 1.00 60.61  ?  398  LEU   C CB    1 
ATOM   1985 C CG    . LEU   A 1 398  ? 193.865 111.038 156.613 1.00 64.30  ?  398  LEU   C CG    1 
ATOM   1986 C CD1   . LEU   A 1 398  ? 194.766 109.813 156.469 1.00 64.63  ?  398  LEU   C CD1   1 
ATOM   1987 C CD2   . LEU   A 1 398  ? 194.471 112.061 157.537 1.00 73.14  ?  398  LEU   C CD2   1 
ATOM   1988 N N     . ILE   A 1 399  ? 190.640 111.211 154.905 1.00 56.54  ?  399  ILE   C N     1 
ATOM   1989 C CA    . ILE   A 1 399  ? 189.358 110.835 155.472 1.00 53.78  ?  399  ILE   C CA    1 
ATOM   1990 C C     . ILE   A 1 399  ? 188.639 109.849 154.560 1.00 53.16  ?  399  ILE   C C     1 
ATOM   1991 O O     . ILE   A 1 399  ? 188.065 108.872 155.029 1.00 55.87  ?  399  ILE   C O     1 
ATOM   1992 C CB    . ILE   A 1 399  ? 188.485 112.072 155.708 1.00 49.00  ?  399  ILE   C CB    1 
ATOM   1993 C CG1   . ILE   A 1 399  ? 189.148 112.944 156.769 1.00 51.24  ?  399  ILE   C CG1   1 
ATOM   1994 C CG2   . ILE   A 1 399  ? 187.091 111.639 156.162 1.00 50.19  ?  399  ILE   C CG2   1 
ATOM   1995 C CD1   . ILE   A 1 399  ? 188.577 114.320 156.864 1.00 53.25  ?  399  ILE   C CD1   1 
ATOM   1996 N N     . GLN   A 1 400  ? 188.677 110.101 153.257 1.00 54.56  ?  400  GLN   C N     1 
ATOM   1997 C CA    . GLN   A 1 400  ? 188.015 109.238 152.289 1.00 55.63  ?  400  GLN   C CA    1 
ATOM   1998 C C     . GLN   A 1 400  ? 188.532 107.804 152.370 1.00 57.16  ?  400  GLN   C C     1 
ATOM   1999 O O     . GLN   A 1 400  ? 187.757 106.855 152.251 1.00 60.36  ?  400  GLN   C O     1 
ATOM   2000 C CB    . GLN   A 1 400  ? 188.217 109.783 150.872 1.00 58.39  ?  400  GLN   C CB    1 
ATOM   2001 C CG    . GLN   A 1 400  ? 187.523 108.988 149.773 1.00 57.31  ?  400  GLN   C CG    1 
ATOM   2002 C CD    . GLN   A 1 400  ? 186.014 109.052 149.842 1.00 58.02  ?  400  GLN   C CD    1 
ATOM   2003 O OE1   . GLN   A 1 400  ? 185.422 110.128 149.768 1.00 57.88  ?  400  GLN   C OE1   1 
ATOM   2004 N NE2   . GLN   A 1 400  ? 185.381 107.893 149.979 1.00 61.44  ?  400  GLN   C NE2   1 
ATOM   2005 N N     . GLU   A 1 401  ? 189.838 107.643 152.598 1.00 58.78  ?  401  GLU   C N     1 
ATOM   2006 C CA    . GLU   A 1 401  ? 190.407 106.306 152.760 1.00 62.36  ?  401  GLU   C CA    1 
ATOM   2007 C C     . GLU   A 1 401  ? 189.803 105.622 153.983 1.00 61.48  ?  401  GLU   C C     1 
ATOM   2008 O O     . GLU   A 1 401  ? 189.520 104.422 153.970 1.00 63.37  ?  401  GLU   C O     1 
ATOM   2009 C CB    . GLU   A 1 401  ? 191.930 106.371 152.898 1.00 65.60  ?  401  GLU   C CB    1 
ATOM   2010 C CG    . GLU   A 1 401  ? 192.665 106.745 151.622 1.00 72.24  ?  401  GLU   C CG    1 
ATOM   2011 C CD    . GLU   A 1 401  ? 194.149 106.874 151.824 1.00 81.45  ?  401  GLU   C CD    1 
ATOM   2012 O OE1   . GLU   A 1 401  ? 194.581 106.842 152.952 1.00 76.74  ?  401  GLU   C OE1   1 
ATOM   2013 O OE2   . GLU   A 1 401  ? 194.853 107.002 150.850 1.00 79.90  -1 401  GLU   C OE2   1 
ATOM   2014 N N     . ASN   A 1 402  ? 189.573 106.400 155.030 1.00 59.48  ?  402  ASN   C N     1 
ATOM   2015 C CA    . ASN   A 1 402  ? 188.957 105.875 156.235 1.00 57.32  ?  402  ASN   C CA    1 
ATOM   2016 C C     . ASN   A 1 402  ? 187.448 105.838 156.045 1.00 55.27  ?  402  ASN   C C     1 
ATOM   2017 O O     . ASN   A 1 402  ? 186.727 106.751 156.445 1.00 55.58  ?  402  ASN   C O     1 
ATOM   2018 C CB    . ASN   A 1 402  ? 189.350 106.717 157.436 1.00 58.89  ?  402  ASN   C CB    1 
ATOM   2019 C CG    . ASN   A 1 402  ? 188.849 106.175 158.745 1.00 58.35  ?  402  ASN   C CG    1 
ATOM   2020 O OD1   . ASN   A 1 402  ? 187.876 105.410 158.796 1.00 56.49  ?  402  ASN   C OD1   1 
ATOM   2021 N ND2   . ASN   A 1 402  ? 189.489 106.572 159.815 1.00 59.90  ?  402  ASN   C ND2   1 
ATOM   2022 N N     . GLU   A 1 403  ? 186.973 104.761 155.429 1.00 55.82  ?  403  GLU   C N     1 
ATOM   2023 C CA    . GLU   A 1 403  ? 185.567 104.639 155.063 1.00 55.85  ?  403  GLU   C CA    1 
ATOM   2024 C C     . GLU   A 1 403  ? 184.648 104.846 156.258 1.00 52.14  ?  403  GLU   C C     1 
ATOM   2025 O O     . GLU   A 1 403  ? 183.581 105.455 156.137 1.00 51.37  ?  403  GLU   C O     1 
ATOM   2026 C CB    . GLU   A 1 403  ? 185.302 103.268 154.442 1.00 58.08  ?  403  GLU   C CB    1 
ATOM   2027 C CG    . GLU   A 1 403  ? 183.879 103.063 153.947 1.00 63.64  ?  403  GLU   C CG    1 
ATOM   2028 C CD    . GLU   A 1 403  ? 183.682 101.727 153.290 1.00 75.41  ?  403  GLU   C CD    1 
ATOM   2029 O OE1   . GLU   A 1 403  ? 184.629 100.984 153.209 1.00 72.86  ?  403  GLU   C OE1   1 
ATOM   2030 O OE2   . GLU   A 1 403  ? 182.585 101.452 152.870 1.00 79.17  -1 403  GLU   C OE2   1 
ATOM   2031 N N     . VAL   A 1 404  ? 185.053 104.324 157.407 1.00 51.69  ?  404  VAL   C N     1 
ATOM   2032 C CA    . VAL   A 1 404  ? 184.239 104.417 158.607 1.00 52.11  ?  404  VAL   C CA    1 
ATOM   2033 C C     . VAL   A 1 404  ? 184.123 105.857 159.098 1.00 50.63  ?  404  VAL   C C     1 
ATOM   2034 O O     . VAL   A 1 404  ? 183.027 106.326 159.410 1.00 50.83  ?  404  VAL   C O     1 
ATOM   2035 C CB    . VAL   A 1 404  ? 184.827 103.515 159.704 1.00 56.38  ?  404  VAL   C CB    1 
ATOM   2036 C CG1   . VAL   A 1 404  ? 184.108 103.734 161.007 1.00 55.95  ?  404  VAL   C CG1   1 
ATOM   2037 C CG2   . VAL   A 1 404  ? 184.697 102.061 159.275 1.00 59.80  ?  404  VAL   C CG2   1 
ATOM   2038 N N     . LEU   A 1 405  ? 185.244 106.568 159.144 1.00 51.39  ?  405  LEU   C N     1 
ATOM   2039 C CA    . LEU   A 1 405  ? 185.226 107.960 159.573 1.00 48.81  ?  405  LEU   C CA    1 
ATOM   2040 C C     . LEU   A 1 405  ? 184.464 108.823 158.586 1.00 44.18  ?  405  LEU   C C     1 
ATOM   2041 O O     . LEU   A 1 405  ? 183.738 109.737 158.980 1.00 43.62  ?  405  LEU   C O     1 
ATOM   2042 C CB    . LEU   A 1 405  ? 186.648 108.496 159.713 1.00 48.54  ?  405  LEU   C CB    1 
ATOM   2043 C CG    . LEU   A 1 405  ? 186.799 109.943 160.199 1.00 48.94  ?  405  LEU   C CG    1 
ATOM   2044 C CD1   . LEU   A 1 405  ? 186.186 110.087 161.584 1.00 49.45  ?  405  LEU   C CD1   1 
ATOM   2045 C CD2   . LEU   A 1 405  ? 188.269 110.288 160.217 1.00 53.67  ?  405  LEU   C CD2   1 
ATOM   2046 N N     . PHE   A 1 406  ? 184.639 108.539 157.303 1.00 48.08  ?  406  PHE   C N     1 
ATOM   2047 C CA    . PHE   A 1 406  ? 183.970 109.296 156.261 1.00 48.30  ?  406  PHE   C CA    1 
ATOM   2048 C C     . PHE   A 1 406  ? 182.468 109.146 156.415 1.00 48.43  ?  406  PHE   C C     1 
ATOM   2049 O O     . PHE   A 1 406  ? 181.723 110.118 156.290 1.00 51.08  ?  406  PHE   C O     1 
ATOM   2050 C CB    . PHE   A 1 406  ? 184.437 108.848 154.882 1.00 51.49  ?  406  PHE   C CB    1 
ATOM   2051 C CG    . PHE   A 1 406  ? 183.899 109.666 153.747 1.00 46.59  ?  406  PHE   C CG    1 
ATOM   2052 C CD1   . PHE   A 1 406  ? 184.313 110.973 153.558 1.00 47.54  ?  406  PHE   C CD1   1 
ATOM   2053 C CD2   . PHE   A 1 406  ? 182.997 109.128 152.852 1.00 48.30  ?  406  PHE   C CD2   1 
ATOM   2054 C CE1   . PHE   A 1 406  ? 183.838 111.716 152.513 1.00 52.07  ?  406  PHE   C CE1   1 
ATOM   2055 C CE2   . PHE   A 1 406  ? 182.522 109.873 151.798 1.00 51.33  ?  406  PHE   C CE2   1 
ATOM   2056 C CZ    . PHE   A 1 406  ? 182.945 111.170 151.630 1.00 53.67  ?  406  PHE   C CZ    1 
ATOM   2057 N N     . THR   A 1 407  ? 182.025 107.926 156.715 1.00 45.03  ?  407  THR   C N     1 
ATOM   2058 C CA    . THR   A 1 407  ? 180.614 107.669 156.961 1.00 42.49  ?  407  THR   C CA    1 
ATOM   2059 C C     . THR   A 1 407  ? 180.105 108.503 158.131 1.00 42.33  ?  407  THR   C C     1 
ATOM   2060 O O     . THR   A 1 407  ? 179.059 109.144 158.037 1.00 42.53  ?  407  THR   C O     1 
ATOM   2061 C CB    . THR   A 1 407  ? 180.369 106.177 157.257 1.00 47.10  ?  407  THR   C CB    1 
ATOM   2062 O OG1   . THR   A 1 407  ? 180.726 105.402 156.106 1.00 53.28  ?  407  THR   C OG1   1 
ATOM   2063 C CG2   . THR   A 1 407  ? 178.905 105.928 157.617 1.00 46.97  ?  407  THR   C CG2   1 
ATOM   2064 N N     . MET   A 1 408  ? 180.857 108.524 159.229 1.00 42.52  ?  408  MET   C N     1 
ATOM   2065 C CA    . MET   A 1 408  ? 180.452 109.293 160.402 1.00 38.99  ?  408  MET   C CA    1 
ATOM   2066 C C     . MET   A 1 408  ? 180.405 110.785 160.103 1.00 38.78  ?  408  MET   C C     1 
ATOM   2067 O O     . MET   A 1 408  ? 179.574 111.508 160.658 1.00 38.89  ?  408  MET   C O     1 
ATOM   2068 C CB    . MET   A 1 408  ? 181.387 109.022 161.579 1.00 36.82  ?  408  MET   C CB    1 
ATOM   2069 C CG    . MET   A 1 408  ? 181.240 107.645 162.197 1.00 42.40  ?  408  MET   C CG    1 
ATOM   2070 S SD    . MET   A 1 408  ? 182.128 107.469 163.762 1.00 47.91  ?  408  MET   C SD    1 
ATOM   2071 C CE    . MET   A 1 408  ? 183.817 107.377 163.215 1.00 49.12  ?  408  MET   C CE    1 
ATOM   2072 N N     . CYS   A 1 409  ? 181.269 111.243 159.198 1.00 38.96  ?  409  CYS   C N     1 
ATOM   2073 C CA    . CYS   A 1 409  ? 181.352 112.658 158.851 1.00 37.63  ?  409  CYS   C CA    1 
ATOM   2074 C C     . CYS   A 1 409  ? 180.098 113.200 158.171 1.00 33.51  ?  409  CYS   C C     1 
ATOM   2075 O O     . CYS   A 1 409  ? 180.029 114.392 157.875 1.00 39.59  ?  409  CYS   C O     1 
ATOM   2076 C CB    . CYS   A 1 409  ? 182.550 112.930 157.939 1.00 41.33  ?  409  CYS   C CB    1 
ATOM   2077 S SG    . CYS   A 1 409  ? 184.157 112.782 158.752 1.00 53.38  ?  409  CYS   C SG    1 
ATOM   2078 N N     . PHE   A 1 410  ? 179.090 112.356 157.941 1.00 32.02  ?  410  PHE   C N     1 
ATOM   2079 C CA    . PHE   A 1 410  ? 177.840 112.863 157.389 1.00 34.93  ?  410  PHE   C CA    1 
ATOM   2080 C C     . PHE   A 1 410  ? 177.193 113.814 158.401 1.00 34.97  ?  410  PHE   C C     1 
ATOM   2081 O O     . PHE   A 1 410  ? 176.398 114.679 158.030 1.00 36.37  ?  410  PHE   C O     1 
ATOM   2082 C CB    . PHE   A 1 410  ? 176.891 111.728 156.993 1.00 37.54  ?  410  PHE   C CB    1 
ATOM   2083 C CG    . PHE   A 1 410  ? 175.903 111.300 158.024 1.00 36.88  ?  410  PHE   C CG    1 
ATOM   2084 C CD1   . PHE   A 1 410  ? 174.613 111.808 157.997 1.00 33.56  ?  410  PHE   C CD1   1 
ATOM   2085 C CD2   . PHE   A 1 410  ? 176.234 110.404 159.011 1.00 43.07  ?  410  PHE   C CD2   1 
ATOM   2086 C CE1   . PHE   A 1 410  ? 173.683 111.420 158.928 1.00 36.76  ?  410  PHE   C CE1   1 
ATOM   2087 C CE2   . PHE   A 1 410  ? 175.310 110.016 159.942 1.00 43.69  ?  410  PHE   C CE2   1 
ATOM   2088 C CZ    . PHE   A 1 410  ? 174.031 110.521 159.899 1.00 43.73  ?  410  PHE   C CZ    1 
ATOM   2089 N N     . ILE   A 1 411  ? 177.564 113.668 159.680 1.00 33.32  ?  411  ILE   C N     1 
ATOM   2090 C CA    . ILE   A 1 411  ? 177.138 114.588 160.733 1.00 30.08  ?  411  ILE   C CA    1 
ATOM   2091 C C     . ILE   A 1 411  ? 178.103 115.773 160.790 1.00 33.96  ?  411  ILE   C C     1 
ATOM   2092 O O     . ILE   A 1 411  ? 179.276 115.587 161.117 1.00 35.60  ?  411  ILE   C O     1 
ATOM   2093 C CB    . ILE   A 1 411  ? 177.148 113.906 162.114 1.00 28.62  ?  411  ILE   C CB    1 
ATOM   2094 C CG1   . ILE   A 1 411  ? 176.197 112.717 162.150 1.00 34.17  ?  411  ILE   C CG1   1 
ATOM   2095 C CG2   . ILE   A 1 411  ? 176.807 114.908 163.202 1.00 34.37  ?  411  ILE   C CG2   1 
ATOM   2096 C CD1   . ILE   A 1 411  ? 174.742 113.059 161.904 1.00 39.89  ?  411  ILE   C CD1   1 
ATOM   2097 N N     . PRO   A 1 412  ? 177.634 116.998 160.536 1.00 29.11  ?  412  PRO   C N     1 
ATOM   2098 C CA    . PRO   A 1 412  ? 178.409 118.219 160.499 1.00 27.19  ?  412  PRO   C CA    1 
ATOM   2099 C C     . PRO   A 1 412  ? 179.345 118.356 161.689 1.00 31.33  ?  412  PRO   C C     1 
ATOM   2100 O O     . PRO   A 1 412  ? 180.504 118.733 161.524 1.00 36.72  ?  412  PRO   C O     1 
ATOM   2101 C CB    . PRO   A 1 412  ? 177.313 119.280 160.520 1.00 29.11  ?  412  PRO   C CB    1 
ATOM   2102 C CG    . PRO   A 1 412  ? 176.178 118.626 159.796 1.00 31.32  ?  412  PRO   C CG    1 
ATOM   2103 C CD    . PRO   A 1 412  ? 176.220 117.188 160.236 1.00 30.77  ?  412  PRO   C CD    1 
ATOM   2104 N N     . LEU   A 1 413  ? 178.874 118.011 162.880 1.00 30.45  ?  413  LEU   C N     1 
ATOM   2105 C CA    . LEU   A 1 413  ? 179.729 118.110 164.051 1.00 30.17  ?  413  LEU   C CA    1 
ATOM   2106 C C     . LEU   A 1 413  ? 180.939 117.199 163.938 1.00 33.98  ?  413  LEU   C C     1 
ATOM   2107 O O     . LEU   A 1 413  ? 182.033 117.555 164.376 1.00 37.04  ?  413  LEU   C O     1 
ATOM   2108 C CB    . LEU   A 1 413  ? 178.942 117.785 165.320 1.00 24.98  ?  413  LEU   C CB    1 
ATOM   2109 C CG    . LEU   A 1 413  ? 179.723 117.828 166.658 1.00 26.61  ?  413  LEU   C CG    1 
ATOM   2110 C CD1   . LEU   A 1 413  ? 180.317 119.218 166.886 1.00 30.15  ?  413  LEU   C CD1   1 
ATOM   2111 C CD2   . LEU   A 1 413  ? 178.769 117.463 167.793 1.00 36.87  ?  413  LEU   C CD2   1 
ATOM   2112 N N     . VAL   A 1 414  ? 180.755 116.015 163.373 1.00 32.45  ?  414  VAL   C N     1 
ATOM   2113 C CA    . VAL   A 1 414  ? 181.862 115.081 163.290 1.00 33.34  ?  414  VAL   C CA    1 
ATOM   2114 C C     . VAL   A 1 414  ? 182.904 115.592 162.323 1.00 38.38  ?  414  VAL   C C     1 
ATOM   2115 O O     . VAL   A 1 414  ? 184.098 115.552 162.616 1.00 43.21  ?  414  VAL   C O     1 
ATOM   2116 C CB    . VAL   A 1 414  ? 181.387 113.687 162.857 1.00 35.91  ?  414  VAL   C CB    1 
ATOM   2117 C CG1   . VAL   A 1 414  ? 182.594 112.776 162.599 1.00 39.46  ?  414  VAL   C CG1   1 
ATOM   2118 C CG2   . VAL   A 1 414  ? 180.502 113.103 163.943 1.00 38.55  ?  414  VAL   C CG2   1 
ATOM   2119 N N     . CYS   A 1 415  ? 182.462 116.076 161.167 1.00 37.13  ?  415  CYS   C N     1 
ATOM   2120 C CA    . CYS   A 1 415  ? 183.432 116.558 160.198 1.00 41.65  ?  415  CYS   C CA    1 
ATOM   2121 C C     . CYS   A 1 415  ? 184.128 117.811 160.726 1.00 42.17  ?  415  CYS   C C     1 
ATOM   2122 O O     . CYS   A 1 415  ? 185.303 118.037 160.432 1.00 45.14  ?  415  CYS   C O     1 
ATOM   2123 C CB    . CYS   A 1 415  ? 182.771 116.846 158.850 1.00 39.52  ?  415  CYS   C CB    1 
ATOM   2124 S SG    . CYS   A 1 415  ? 181.715 118.285 158.830 1.00 39.68  ?  415  CYS   C SG    1 
ATOM   2125 N N     . TRP   A 1 416  ? 183.431 118.596 161.551 1.00 39.28  ?  416  TRP   C N     1 
ATOM   2126 C CA    . TRP   A 1 416  ? 184.033 119.768 162.175 1.00 39.01  ?  416  TRP   C CA    1 
ATOM   2127 C C     . TRP   A 1 416  ? 185.165 119.357 163.100 1.00 41.74  ?  416  TRP   C C     1 
ATOM   2128 O O     . TRP   A 1 416  ? 186.266 119.906 163.036 1.00 47.89  ?  416  TRP   C O     1 
ATOM   2129 C CB    . TRP   A 1 416  ? 183.001 120.565 162.971 1.00 36.49  ?  416  TRP   C CB    1 
ATOM   2130 C CG    . TRP   A 1 416  ? 183.560 121.794 163.620 1.00 33.81  ?  416  TRP   C CG    1 
ATOM   2131 C CD1   . TRP   A 1 416  ? 183.645 123.027 163.065 1.00 40.07  ?  416  TRP   C CD1   1 
ATOM   2132 C CD2   . TRP   A 1 416  ? 184.138 121.912 164.941 1.00 35.51  ?  416  TRP   C CD2   1 
ATOM   2133 N NE1   . TRP   A 1 416  ? 184.225 123.899 163.941 1.00 45.58  ?  416  TRP   C NE1   1 
ATOM   2134 C CE2   . TRP   A 1 416  ? 184.522 123.236 165.097 1.00 39.57  ?  416  TRP   C CE2   1 
ATOM   2135 C CE3   . TRP   A 1 416  ? 184.328 121.023 165.992 1.00 42.95  ?  416  TRP   C CE3   1 
ATOM   2136 C CZ2   . TRP   A 1 416  ? 185.126 123.690 166.251 1.00 50.39  ?  416  TRP   C CZ2   1 
ATOM   2137 C CZ3   . TRP   A 1 416  ? 184.931 121.474 167.154 1.00 48.32  ?  416  TRP   C CZ3   1 
ATOM   2138 C CH2   . TRP   A 1 416  ? 185.311 122.775 167.282 1.00 52.30  ?  416  TRP   C CH2   1 
ATOM   2139 N N     . ILE   A 1 417  ? 184.893 118.366 163.949 1.00 41.76  ?  417  ILE   C N     1 
ATOM   2140 C CA    . ILE   A 1 417  ? 185.887 117.902 164.907 1.00 44.11  ?  417  ILE   C CA    1 
ATOM   2141 C C     . ILE   A 1 417  ? 187.100 117.354 164.178 1.00 45.36  ?  417  ILE   C C     1 
ATOM   2142 O O     . ILE   A 1 417  ? 188.241 117.641 164.555 1.00 49.94  ?  417  ILE   C O     1 
ATOM   2143 C CB    . ILE   A 1 417  ? 185.301 116.814 165.836 1.00 40.06  ?  417  ILE   C CB    1 
ATOM   2144 C CG1   . ILE   A 1 417  ? 184.226 117.425 166.747 1.00 42.24  ?  417  ILE   C CG1   1 
ATOM   2145 C CG2   . ILE   A 1 417  ? 186.411 116.205 166.674 1.00 43.56  ?  417  ILE   C CG2   1 
ATOM   2146 C CD1   . ILE   A 1 417  ? 183.395 116.410 167.490 1.00 41.79  ?  417  ILE   C CD1   1 
ATOM   2147 N N     . VAL   A 1 418  ? 186.863 116.571 163.135 1.00 42.27  ?  418  VAL   C N     1 
ATOM   2148 C CA    . VAL   A 1 418  ? 187.949 115.994 162.367 1.00 42.05  ?  418  VAL   C CA    1 
ATOM   2149 C C     . VAL   A 1 418  ? 188.775 117.073 161.686 1.00 50.63  ?  418  VAL   C C     1 
ATOM   2150 O O     . VAL   A 1 418  ? 190.004 117.030 161.718 1.00 55.67  ?  418  VAL   C O     1 
ATOM   2151 C CB    . VAL   A 1 418  ? 187.410 115.020 161.310 1.00 43.23  ?  418  VAL   C CB    1 
ATOM   2152 C CG1   . VAL   A 1 418  ? 188.532 114.564 160.391 1.00 49.66  ?  418  VAL   C CG1   1 
ATOM   2153 C CG2   . VAL   A 1 418  ? 186.784 113.823 161.992 1.00 52.18  ?  418  VAL   C CG2   1 
ATOM   2154 N N     . CYS   A 1 419  ? 188.104 118.044 161.070 1.00 47.28  ?  419  CYS   C N     1 
ATOM   2155 C CA    . CYS   A 1 419  ? 188.812 119.109 160.378 1.00 52.85  ?  419  CYS   C CA    1 
ATOM   2156 C C     . CYS   A 1 419  ? 189.693 119.897 161.330 1.00 54.29  ?  419  CYS   C C     1 
ATOM   2157 O O     . CYS   A 1 419  ? 190.848 120.188 161.018 1.00 58.77  ?  419  CYS   C O     1 
ATOM   2158 C CB    . CYS   A 1 419  ? 187.832 120.076 159.722 1.00 51.35  ?  419  CYS   C CB    1 
ATOM   2159 S SG    . CYS   A 1 419  ? 186.955 119.417 158.321 1.00 53.21  ?  419  CYS   C SG    1 
ATOM   2160 N N     . THR   A 1 420  ? 189.153 120.231 162.497 1.00 49.51  ?  420  THR   C N     1 
ATOM   2161 C CA    . THR   A 1 420  ? 189.898 121.007 163.472 1.00 48.09  ?  420  THR   C CA    1 
ATOM   2162 C C     . THR   A 1 420  ? 191.120 120.238 163.942 1.00 55.02  ?  420  THR   C C     1 
ATOM   2163 O O     . THR   A 1 420  ? 192.215 120.795 164.036 1.00 61.52  ?  420  THR   C O     1 
ATOM   2164 C CB    . THR   A 1 420  ? 189.010 121.379 164.674 1.00 49.66  ?  420  THR   C CB    1 
ATOM   2165 O OG1   . THR   A 1 420  ? 187.915 122.185 164.222 1.00 47.99  ?  420  THR   C OG1   1 
ATOM   2166 C CG2   . THR   A 1 420  ? 189.812 122.160 165.709 1.00 57.66  ?  420  THR   C CG2   1 
ATOM   2167 N N     . GLY   A 1 421  ? 190.940 118.953 164.223 1.00 54.04  ?  421  GLY   C N     1 
ATOM   2168 C CA    . GLY   A 1 421  ? 192.040 118.118 164.677 1.00 61.08  ?  421  GLY   C CA    1 
ATOM   2169 C C     . GLY   A 1 421  ? 193.153 118.056 163.636 1.00 63.17  ?  421  GLY   C C     1 
ATOM   2170 O O     . GLY   A 1 421  ? 194.330 118.239 163.962 1.00 69.69  ?  421  GLY   C O     1 
ATOM   2171 N N     . LEU   A 1 422  ? 192.787 117.796 162.381 1.00 59.41  ?  422  LEU   C N     1 
ATOM   2172 C CA    . LEU   A 1 422  ? 193.784 117.696 161.326 1.00 62.24  ?  422  LEU   C CA    1 
ATOM   2173 C C     . LEU   A 1 422  ? 194.495 119.021 161.109 1.00 68.42  ?  422  LEU   C C     1 
ATOM   2174 O O     . LEU   A 1 422  ? 195.706 119.048 160.899 1.00 74.30  ?  422  LEU   C O     1 
ATOM   2175 C CB    . LEU   A 1 422  ? 193.141 117.245 160.009 1.00 59.39  ?  422  LEU   C CB    1 
ATOM   2176 C CG    . LEU   A 1 422  ? 192.633 115.786 159.946 1.00 65.53  ?  422  LEU   C CG    1 
ATOM   2177 C CD1   . LEU   A 1 422  ? 191.861 115.598 158.652 1.00 66.30  ?  422  LEU   C CD1   1 
ATOM   2178 C CD2   . LEU   A 1 422  ? 193.812 114.809 160.009 1.00 71.60  ?  422  LEU   C CD2   1 
ATOM   2179 N N     . LYS   A 1 423  ? 193.756 120.123 161.170 1.00 65.52  ?  423  LYS   C N     1 
ATOM   2180 C CA    . LYS   A 1 423  ? 194.367 121.427 160.967 1.00 68.10  ?  423  LYS   C CA    1 
ATOM   2181 C C     . LYS   A 1 423  ? 195.387 121.723 162.058 1.00 70.58  ?  423  LYS   C C     1 
ATOM   2182 O O     . LYS   A 1 423  ? 196.481 122.215 161.776 1.00 74.71  ?  423  LYS   C O     1 
ATOM   2183 C CB    . LYS   A 1 423  ? 193.304 122.525 160.926 1.00 65.08  ?  423  LYS   C CB    1 
ATOM   2184 C CG    . LYS   A 1 423  ? 193.850 123.924 160.638 1.00 67.99  ?  423  LYS   C CG    1 
ATOM   2185 C CD    . LYS   A 1 423  ? 192.723 124.951 160.544 1.00 71.06  ?  423  LYS   C CD    1 
ATOM   2186 C CE    . LYS   A 1 423  ? 193.239 126.335 160.163 1.00 90.84  ?  423  LYS   C CE    1 
ATOM   2187 N NZ    . LYS   A 1 423  ? 194.197 126.881 161.170 1.00 95.39  1  423  LYS   C NZ    1 
ATOM   2188 N N     . GLN   A 1 424  ? 195.032 121.418 163.304 1.00 69.70  ?  424  GLN   C N     1 
ATOM   2189 C CA    . GLN   A 1 424  ? 195.914 121.707 164.424 1.00 76.37  ?  424  GLN   C CA    1 
ATOM   2190 C C     . GLN   A 1 424  ? 197.223 120.936 164.349 1.00 78.36  ?  424  GLN   C C     1 
ATOM   2191 O O     . GLN   A 1 424  ? 198.280 121.485 164.657 1.00 83.39  ?  424  GLN   C O     1 
ATOM   2192 C CB    . GLN   A 1 424  ? 195.210 121.409 165.750 1.00 75.86  ?  424  GLN   C CB    1 
ATOM   2193 C CG    . GLN   A 1 424  ? 194.110 122.400 166.107 1.00 78.70  ?  424  GLN   C CG    1 
ATOM   2194 C CD    . GLN   A 1 424  ? 193.332 121.985 167.339 1.00 85.86  ?  424  GLN   C CD    1 
ATOM   2195 O OE1   . GLN   A 1 424  ? 193.450 120.851 167.811 1.00 81.47  ?  424  GLN   C OE1   1 
ATOM   2196 N NE2   . GLN   A 1 424  ? 192.531 122.901 167.868 1.00 82.69  ?  424  GLN   C NE2   1 
ATOM   2197 N N     . GLN   A 1 425  ? 197.175 119.671 163.935 1.00 77.00  ?  425  GLN   C N     1 
ATOM   2198 C CA    . GLN   A 1 425  ? 198.422 118.923 163.821 1.00 81.73  ?  425  GLN   C CA    1 
ATOM   2199 C C     . GLN   A 1 425  ? 199.176 119.299 162.545 1.00 84.63  ?  425  GLN   C C     1 
ATOM   2200 O O     . GLN   A 1 425  ? 200.408 119.290 162.515 1.00 85.87  ?  425  GLN   C O     1 
ATOM   2201 C CB    . GLN   A 1 425  ? 198.165 117.412 163.852 1.00 80.85  ?  425  GLN   C CB    1 
ATOM   2202 C CG    . GLN   A 1 425  ? 197.543 116.860 162.600 1.00 80.63  ?  425  GLN   C CG    1 
ATOM   2203 C CD    . GLN   A 1 425  ? 197.410 115.362 162.623 1.00 82.85  ?  425  GLN   C CD    1 
ATOM   2204 O OE1   . GLN   A 1 425  ? 198.402 114.636 162.463 1.00 87.47  ?  425  GLN   C OE1   1 
ATOM   2205 N NE2   . GLN   A 1 425  ? 196.191 114.882 162.804 1.00 77.60  ?  425  GLN   C NE2   1 
ATOM   2206 N N     . MET   A 1 426  ? 198.441 119.696 161.510 1.00 80.22  ?  426  MET   C N     1 
ATOM   2207 C CA    . MET   A 1 426  ? 199.048 120.087 160.244 1.00 84.25  ?  426  MET   C CA    1 
ATOM   2208 C C     . MET   A 1 426  ? 199.970 121.283 160.432 1.00 87.12  ?  426  MET   C C     1 
ATOM   2209 O O     . MET   A 1 426  ? 201.063 121.337 159.867 1.00 89.37  ?  426  MET   C O     1 
ATOM   2210 C CB    . MET   A 1 426  ? 197.960 120.404 159.226 1.00 82.27  ?  426  MET   C CB    1 
ATOM   2211 C CG    . MET   A 1 426  ? 198.450 120.817 157.858 1.00 83.78  ?  426  MET   C CG    1 
ATOM   2212 S SD    . MET   A 1 426  ? 197.088 121.113 156.715 1.00 88.95  ?  426  MET   C SD    1 
ATOM   2213 C CE    . MET   A 1 426  ? 196.412 122.644 157.360 1.00 80.28  ?  426  MET   C CE    1 
ATOM   2214 N N     . GLU   A 1 427  ? 199.539 122.222 161.264 1.00 85.92  ?  427  GLU   C N     1 
ATOM   2215 C CA    . GLU   A 1 427  ? 200.300 123.432 161.555 1.00 89.11  ?  427  GLU   C CA    1 
ATOM   2216 C C     . GLU   A 1 427  ? 201.604 123.133 162.290 1.00 89.97  ?  427  GLU   C C     1 
ATOM   2217 O O     . GLU   A 1 427  ? 202.490 123.984 162.361 1.00 93.62  ?  427  GLU   C O     1 
ATOM   2218 C CB    . GLU   A 1 427  ? 199.455 124.403 162.379 1.00 90.50  ?  427  GLU   C CB    1 
ATOM   2219 C CG    . GLU   A 1 427  ? 198.309 125.041 161.613 1.00 92.37  ?  427  GLU   C CG    1 
ATOM   2220 C CD    . GLU   A 1 427  ? 197.438 125.917 162.473 1.00 96.60  ?  427  GLU   C CD    1 
ATOM   2221 O OE1   . GLU   A 1 427  ? 197.677 125.991 163.653 1.00 94.66  ?  427  GLU   C OE1   1 
ATOM   2222 O OE2   . GLU   A 1 427  ? 196.519 126.506 161.946 1.00 93.66  -1 427  GLU   C OE2   1 
ATOM   2223 N N     . SER   A 1 428  ? 201.709 121.934 162.857 1.00 91.18  ?  428  SER   C N     1 
ATOM   2224 C CA    . SER   A 1 428  ? 202.889 121.523 163.602 1.00 93.91  ?  428  SER   C CA    1 
ATOM   2225 C C     . SER   A 1 428  ? 203.819 120.684 162.733 1.00 94.36  ?  428  SER   C C     1 
ATOM   2226 O O     . SER   A 1 428  ? 204.844 120.191 163.204 1.00 94.69  ?  428  SER   C O     1 
ATOM   2227 C CB    . SER   A 1 428  ? 202.487 120.741 164.838 1.00 94.55  ?  428  SER   C CB    1 
ATOM   2228 O OG    . SER   A 1 428  ? 201.781 121.549 165.741 1.00 94.28  ?  428  SER   C OG    1 
ATOM   2229 N N     . GLY   A 1 429  ? 203.453 120.516 161.463 1.00 95.32  ?  429  GLY   C N     1 
ATOM   2230 C CA    . GLY   A 1 429  ? 204.256 119.737 160.531 1.00 99.00  ?  429  GLY   C CA    1 
ATOM   2231 C C     . GLY   A 1 429  ? 204.038 118.234 160.670 1.00 99.03  ?  429  GLY   C C     1 
ATOM   2232 O O     . GLY   A 1 429  ? 204.928 117.445 160.350 1.00 101.70 ?  429  GLY   C O     1 
ATOM   2233 N N     . LYS   A 1 430  ? 202.862 117.831 161.145 1.00 96.79  ?  430  LYS   C N     1 
ATOM   2234 C CA    . LYS   A 1 430  ? 202.573 116.414 161.312 1.00 96.44  ?  430  LYS   C CA    1 
ATOM   2235 C C     . LYS   A 1 430  ? 202.092 115.797 160.003 1.00 95.21  ?  430  LYS   C C     1 
ATOM   2236 O O     . LYS   A 1 430  ? 201.790 116.501 159.039 1.00 92.76  ?  430  LYS   C O     1 
ATOM   2237 C CB    . LYS   A 1 430  ? 201.551 116.196 162.427 1.00 94.88  ?  430  LYS   C CB    1 
ATOM   2238 C CG    . LYS   A 1 430  ? 201.985 116.749 163.796 1.00 95.80  ?  430  LYS   C CG    1 
ATOM   2239 C CD    . LYS   A 1 430  ? 203.236 116.058 164.323 1.00 102.07 ?  430  LYS   C CD    1 
ATOM   2240 C CE    . LYS   A 1 430  ? 203.557 116.513 165.738 1.00 107.65 ?  430  LYS   C CE    1 
ATOM   2241 N NZ    . LYS   A 1 430  ? 204.810 115.896 166.247 1.00 112.93 1  430  LYS   C NZ    1 
ATOM   2242 N N     . SER   A 1 431  ? 202.052 114.469 159.970 1.00 93.52  ?  431  SER   C N     1 
ATOM   2243 C CA    . SER   A 1 431  ? 201.709 113.707 158.772 1.00 92.42  ?  431  SER   C CA    1 
ATOM   2244 C C     . SER   A 1 431  ? 200.211 113.465 158.605 1.00 87.81  ?  431  SER   C C     1 
ATOM   2245 O O     . SER   A 1 431  ? 199.801 112.661 157.769 1.00 86.64  ?  431  SER   C O     1 
ATOM   2246 C CB    . SER   A 1 431  ? 202.430 112.375 158.799 1.00 94.87  ?  431  SER   C CB    1 
ATOM   2247 O OG    . SER   A 1 431  ? 202.022 111.609 159.901 1.00 89.52  ?  431  SER   C OG    1 
ATOM   2248 N N     . LEU   A 1 432  ? 199.406 114.154 159.409 1.00 86.54  ?  432  LEU   C N     1 
ATOM   2249 C CA    . LEU   A 1 432  ? 197.949 114.018 159.387 1.00 83.75  ?  432  LEU   C CA    1 
ATOM   2250 C C     . LEU   A 1 432  ? 197.507 112.640 159.855 1.00 80.93  ?  432  LEU   C C     1 
ATOM   2251 O O     . LEU   A 1 432  ? 196.917 111.872 159.094 1.00 76.88  ?  432  LEU   C O     1 
ATOM   2252 C CB    . LEU   A 1 432  ? 197.380 114.288 157.986 1.00 79.70  ?  432  LEU   C CB    1 
ATOM   2253 C CG    . LEU   A 1 432  ? 197.714 115.644 157.355 1.00 82.67  ?  432  LEU   C CG    1 
ATOM   2254 C CD1   . LEU   A 1 432  ? 197.121 115.689 155.951 1.00 76.98  ?  432  LEU   C CD1   1 
ATOM   2255 C CD2   . LEU   A 1 432  ? 197.149 116.770 158.215 1.00 83.83  ?  432  LEU   C CD2   1 
ATOM   2256 N N     . ALA   A 1 433  ? 197.800 112.317 161.107 1.00 81.28  ?  433  ALA   C N     1 
ATOM   2257 C CA    . ALA   A 1 433  ? 197.369 111.052 161.679 1.00 79.74  ?  433  ALA   C CA    1 
ATOM   2258 C C     . ALA   A 1 433  ? 195.865 111.071 161.894 1.00 75.75  ?  433  ALA   C C     1 
ATOM   2259 O O     . ALA   A 1 433  ? 195.309 112.101 162.277 1.00 73.50  ?  433  ALA   C O     1 
ATOM   2260 C CB    . ALA   A 1 433  ? 198.087 110.781 162.992 1.00 79.68  ?  433  ALA   C CB    1 
ATOM   2261 N N     . GLN   A 1 434  ? 195.220 109.927 161.684 1.00 71.40  ?  434  GLN   C N     1 
ATOM   2262 C CA    . GLN   A 1 434  ? 193.786 109.776 161.926 1.00 67.10  ?  434  GLN   C CA    1 
ATOM   2263 C C     . GLN   A 1 434  ? 193.336 108.339 161.692 1.00 64.47  ?  434  GLN   C C     1 
ATOM   2264 O O     . GLN   A 1 434  ? 193.173 107.908 160.550 1.00 63.43  ?  434  GLN   C O     1 
ATOM   2265 C CB    . GLN   A 1 434  ? 192.983 110.728 161.034 1.00 64.53  ?  434  GLN   C CB    1 
ATOM   2266 C CG    . GLN   A 1 434  ? 191.485 110.559 161.128 1.00 63.10  ?  434  GLN   C CG    1 
ATOM   2267 C CD    . GLN   A 1 434  ? 190.950 110.794 162.521 1.00 63.30  ?  434  GLN   C CD    1 
ATOM   2268 O OE1   . GLN   A 1 434  ? 190.989 109.887 163.362 1.00 65.55  ?  434  GLN   C OE1   1 
ATOM   2269 N NE2   . GLN   A 1 434  ? 190.436 111.994 162.778 1.00 57.71  ?  434  GLN   C NE2   1 
ATOM   2270 N N     . THR   A 1 435  ? 193.155 107.598 162.779 1.00 63.88  ?  435  THR   C N     1 
ATOM   2271 C CA    . THR   A 1 435  ? 192.784 106.190 162.706 1.00 62.62  ?  435  THR   C CA    1 
ATOM   2272 C C     . THR   A 1 435  ? 191.463 105.903 163.404 1.00 61.72  ?  435  THR   C C     1 
ATOM   2273 O O     . THR   A 1 435  ? 191.150 104.748 163.698 1.00 63.55  ?  435  THR   C O     1 
ATOM   2274 C CB    . THR   A 1 435  ? 193.878 105.307 163.328 1.00 68.55  ?  435  THR   C CB    1 
ATOM   2275 O OG1   . THR   A 1 435  ? 194.066 105.675 164.702 1.00 67.30  ?  435  THR   C OG1   1 
ATOM   2276 C CG2   . THR   A 1 435  ? 195.180 105.494 162.577 1.00 68.84  ?  435  THR   C CG2   1 
ATOM   2277 N N     . SER   A 1 436  ? 190.700 106.947 163.705 1.00 59.43  ?  436  SER   C N     1 
ATOM   2278 C CA    . SER   A 1 436  ? 189.448 106.779 164.433 1.00 55.80  ?  436  SER   C CA    1 
ATOM   2279 C C     . SER   A 1 436  ? 188.422 105.970 163.647 1.00 54.49  ?  436  SER   C C     1 
ATOM   2280 O O     . SER   A 1 436  ? 188.268 106.144 162.439 1.00 55.46  ?  436  SER   C O     1 
ATOM   2281 C CB    . SER   A 1 436  ? 188.872 108.134 164.776 1.00 53.86  ?  436  SER   C CB    1 
ATOM   2282 O OG    . SER   A 1 436  ? 189.712 108.822 165.662 1.00 56.15  ?  436  SER   C OG    1 
ATOM   2283 N N     . LYS   A 1 437  ? 187.715 105.087 164.350 1.00 52.86  ?  437  LYS   C N     1 
ATOM   2284 C CA    . LYS   A 1 437  ? 186.656 104.283 163.746 1.00 50.59  ?  437  LYS   C CA    1 
ATOM   2285 C C     . LYS   A 1 437  ? 185.313 104.477 164.443 1.00 47.51  ?  437  LYS   C C     1 
ATOM   2286 O O     . LYS   A 1 437  ? 184.257 104.233 163.860 1.00 50.45  ?  437  LYS   C O     1 
ATOM   2287 C CB    . LYS   A 1 437  ? 187.041 102.806 163.759 1.00 54.57  ?  437  LYS   C CB    1 
ATOM   2288 C CG    . LYS   A 1 437  ? 188.241 102.472 162.893 1.00 62.32  ?  437  LYS   C CG    1 
ATOM   2289 C CD    . LYS   A 1 437  ? 188.539 100.981 162.901 1.00 77.23  ?  437  LYS   C CD    1 
ATOM   2290 C CE    . LYS   A 1 437  ? 189.754 100.655 162.041 1.00 85.63  ?  437  LYS   C CE    1 
ATOM   2291 N NZ    . LYS   A 1 437  ? 190.085 99.201  162.072 1.00 90.65  1  437  LYS   C NZ    1 
ATOM   2292 N N     . THR   A 1 438  ? 185.352 104.884 165.701 1.00 45.55  ?  438  THR   C N     1 
ATOM   2293 C CA    . THR   A 1 438  ? 184.141 105.027 166.494 1.00 41.48  ?  438  THR   C CA    1 
ATOM   2294 C C     . THR   A 1 438  ? 183.925 106.481 166.866 1.00 43.55  ?  438  THR   C C     1 
ATOM   2295 O O     . THR   A 1 438  ? 184.826 107.306 166.699 1.00 48.77  ?  438  THR   C O     1 
ATOM   2296 C CB    . THR   A 1 438  ? 184.215 104.170 167.765 1.00 45.48  ?  438  THR   C CB    1 
ATOM   2297 O OG1   . THR   A 1 438  ? 185.276 104.650 168.608 1.00 47.05  ?  438  THR   C OG1   1 
ATOM   2298 C CG2   . THR   A 1 438  ? 184.471 102.714 167.407 1.00 50.57  ?  438  THR   C CG2   1 
ATOM   2299 N N     . THR   A 1 439  ? 182.738 106.804 167.370 1.00 41.01  ?  439  THR   C N     1 
ATOM   2300 C CA    . THR   A 1 439  ? 182.470 108.175 167.772 1.00 37.06  ?  439  THR   C CA    1 
ATOM   2301 C C     . THR   A 1 439  ? 183.400 108.554 168.906 1.00 39.62  ?  439  THR   C C     1 
ATOM   2302 O O     . THR   A 1 439  ? 183.961 109.650 168.920 1.00 45.85  ?  439  THR   C O     1 
ATOM   2303 C CB    . THR   A 1 439  ? 181.003 108.375 168.200 1.00 39.55  ?  439  THR   C CB    1 
ATOM   2304 O OG1   . THR   A 1 439  ? 180.138 108.071 167.099 1.00 45.78  ?  439  THR   C OG1   1 
ATOM   2305 C CG2   . THR   A 1 439  ? 180.771 109.818 168.631 1.00 41.24  ?  439  THR   C CG2   1 
ATOM   2306 N N     . THR   A 1 440  ? 183.578 107.643 169.851 1.00 39.26  ?  440  THR   C N     1 
ATOM   2307 C CA    . THR   A 1 440  ? 184.454 107.890 170.982 1.00 38.56  ?  440  THR   C CA    1 
ATOM   2308 C C     . THR   A 1 440  ? 185.866 108.148 170.493 1.00 43.71  ?  440  THR   C C     1 
ATOM   2309 O O     . THR   A 1 440  ? 186.517 109.086 170.928 1.00 50.64  ?  440  THR   C O     1 
ATOM   2310 C CB    . THR   A 1 440  ? 184.453 106.715 171.970 1.00 44.32  ?  440  THR   C CB    1 
ATOM   2311 O OG1   . THR   A 1 440  ? 183.125 106.508 172.458 1.00 52.38  ?  440  THR   C OG1   1 
ATOM   2312 C CG2   . THR   A 1 440  ? 185.370 107.016 173.149 1.00 46.94  ?  440  THR   C CG2   1 
ATOM   2313 N N     . ALA   A 1 441  ? 186.321 107.324 169.551 1.00 44.61  ?  441  ALA   C N     1 
ATOM   2314 C CA    . ALA   A 1 441  ? 187.684 107.480 169.045 1.00 50.16  ?  441  ALA   C CA    1 
ATOM   2315 C C     . ALA   A 1 441  ? 187.888 108.871 168.470 1.00 48.40  ?  441  ALA   C C     1 
ATOM   2316 O O     . ALA   A 1 441  ? 188.980 109.445 168.623 1.00 51.77  ?  441  ALA   C O     1 
ATOM   2317 C CB    . ALA   A 1 441  ? 187.951 106.436 167.969 1.00 55.05  ?  441  ALA   C CB    1 
ATOM   2318 N N     . VAL   A 1 442  ? 186.879 109.438 167.829 1.00 43.86  ?  442  VAL   C N     1 
ATOM   2319 C CA    . VAL   A 1 442  ? 186.994 110.769 167.260 1.00 42.08  ?  442  VAL   C CA    1 
ATOM   2320 C C     . VAL   A 1 442  ? 187.182 111.814 168.356 1.00 44.89  ?  442  VAL   C C     1 
ATOM   2321 O O     . VAL   A 1 442  ? 188.041 112.684 168.252 1.00 49.35  ?  442  VAL   C O     1 
ATOM   2322 C CB    . VAL   A 1 442  ? 185.765 111.119 166.399 1.00 39.39  ?  442  VAL   C CB    1 
ATOM   2323 C CG1   . VAL   A 1 442  ? 185.801 112.585 165.983 1.00 39.49  ?  442  VAL   C CG1   1 
ATOM   2324 C CG2   . VAL   A 1 442  ? 185.744 110.227 165.165 1.00 42.55  ?  442  VAL   C CG2   1 
ATOM   2325 N N     . TYR   A 1 443  ? 186.376 111.710 169.412 1.00 44.17  ?  443  TYR   C N     1 
ATOM   2326 C CA    . TYR   A 1 443  ? 186.474 112.655 170.522 1.00 43.89  ?  443  TYR   C CA    1 
ATOM   2327 C C     . TYR   A 1 443  ? 187.763 112.486 171.307 1.00 51.01  ?  443  TYR   C C     1 
ATOM   2328 O O     . TYR   A 1 443  ? 188.381 113.478 171.703 1.00 57.75  ?  443  TYR   C O     1 
ATOM   2329 C CB    . TYR   A 1 443  ? 185.259 112.519 171.435 1.00 41.05  ?  443  TYR   C CB    1 
ATOM   2330 C CG    . TYR   A 1 443  ? 184.072 113.271 170.907 1.00 36.15  ?  443  TYR   C CG    1 
ATOM   2331 C CD1   . TYR   A 1 443  ? 183.312 112.736 169.892 1.00 37.63  ?  443  TYR   C CD1   1 
ATOM   2332 C CD2   . TYR   A 1 443  ? 183.749 114.499 171.432 1.00 39.98  ?  443  TYR   C CD2   1 
ATOM   2333 C CE1   . TYR   A 1 443  ? 182.245 113.426 169.391 1.00 34.37  ?  443  TYR   C CE1   1 
ATOM   2334 C CE2   . TYR   A 1 443  ? 182.675 115.193 170.931 1.00 41.22  ?  443  TYR   C CE2   1 
ATOM   2335 C CZ    . TYR   A 1 443  ? 181.930 114.660 169.912 1.00 36.19  ?  443  TYR   C CZ    1 
ATOM   2336 O OH    . TYR   A 1 443  ? 180.873 115.358 169.398 1.00 39.95  ?  443  TYR   C OH    1 
ATOM   2337 N N     . VAL   A 1 444  ? 188.200 111.249 171.502 1.00 49.25  ?  444  VAL   C N     1 
ATOM   2338 C CA    . VAL   A 1 444  ? 189.446 111.005 172.207 1.00 52.85  ?  444  VAL   C CA    1 
ATOM   2339 C C     . VAL   A 1 444  ? 190.608 111.537 171.388 1.00 61.05  ?  444  VAL   C C     1 
ATOM   2340 O O     . VAL   A 1 444  ? 191.499 112.194 171.919 1.00 68.73  ?  444  VAL   C O     1 
ATOM   2341 C CB    . VAL   A 1 444  ? 189.643 109.508 172.497 1.00 51.27  ?  444  VAL   C CB    1 
ATOM   2342 C CG1   . VAL   A 1 444  ? 191.045 109.254 173.052 1.00 58.39  ?  444  VAL   C CG1   1 
ATOM   2343 C CG2   . VAL   A 1 444  ? 188.603 109.052 173.501 1.00 58.05  ?  444  VAL   C CG2   1 
ATOM   2344 N N     . PHE   A 1 445  ? 190.585 111.261 170.088 1.00 57.54  ?  445  PHE   C N     1 
ATOM   2345 C CA    . PHE   A 1 445  ? 191.611 111.743 169.177 1.00 63.01  ?  445  PHE   C CA    1 
ATOM   2346 C C     . PHE   A 1 445  ? 191.714 113.259 169.238 1.00 63.78  ?  445  PHE   C C     1 
ATOM   2347 O O     . PHE   A 1 445  ? 192.807 113.812 169.373 1.00 69.71  ?  445  PHE   C O     1 
ATOM   2348 C CB    . PHE   A 1 445  ? 191.296 111.300 167.751 1.00 63.54  ?  445  PHE   C CB    1 
ATOM   2349 C CG    . PHE   A 1 445  ? 192.214 111.862 166.728 1.00 63.61  ?  445  PHE   C CG    1 
ATOM   2350 C CD1   . PHE   A 1 445  ? 193.454 111.295 166.502 1.00 61.43  ?  445  PHE   C CD1   1 
ATOM   2351 C CD2   . PHE   A 1 445  ? 191.836 112.964 165.980 1.00 58.50  ?  445  PHE   C CD2   1 
ATOM   2352 C CE1   . PHE   A 1 445  ? 194.297 111.819 165.555 1.00 65.95  ?  445  PHE   C CE1   1 
ATOM   2353 C CE2   . PHE   A 1 445  ? 192.677 113.488 165.034 1.00 64.50  ?  445  PHE   C CE2   1 
ATOM   2354 C CZ    . PHE   A 1 445  ? 193.905 112.914 164.823 1.00 68.57  ?  445  PHE   C CZ    1 
ATOM   2355 N N     . PHE   A 1 446  ? 190.569 113.927 169.150 1.00 59.38  ?  446  PHE   C N     1 
ATOM   2356 C CA    . PHE   A 1 446  ? 190.515 115.379 169.203 1.00 59.22  ?  446  PHE   C CA    1 
ATOM   2357 C C     . PHE   A 1 446  ? 191.144 115.917 170.475 1.00 63.82  ?  446  PHE   C C     1 
ATOM   2358 O O     . PHE   A 1 446  ? 192.018 116.781 170.423 1.00 71.73  ?  446  PHE   C O     1 
ATOM   2359 C CB    . PHE   A 1 446  ? 189.063 115.832 169.127 1.00 54.77  ?  446  PHE   C CB    1 
ATOM   2360 C CG    . PHE   A 1 446  ? 188.840 117.301 169.292 1.00 48.05  ?  446  PHE   C CG    1 
ATOM   2361 C CD1   . PHE   A 1 446  ? 189.042 118.170 168.240 1.00 49.86  ?  446  PHE   C CD1   1 
ATOM   2362 C CD2   . PHE   A 1 446  ? 188.403 117.813 170.499 1.00 53.34  ?  446  PHE   C CD2   1 
ATOM   2363 C CE1   . PHE   A 1 446  ? 188.814 119.516 168.389 1.00 57.96  ?  446  PHE   C CE1   1 
ATOM   2364 C CE2   . PHE   A 1 446  ? 188.174 119.159 170.651 1.00 62.04  ?  446  PHE   C CE2   1 
ATOM   2365 C CZ    . PHE   A 1 446  ? 188.377 120.012 169.595 1.00 62.07  ?  446  PHE   C CZ    1 
ATOM   2366 N N     . LEU   A 1 447  ? 190.713 115.400 171.620 1.00 62.29  ?  447  LEU   C N     1 
ATOM   2367 C CA    . LEU   A 1 447  ? 191.226 115.886 172.891 1.00 69.58  ?  447  LEU   C CA    1 
ATOM   2368 C C     . LEU   A 1 447  ? 192.691 115.548 173.059 1.00 77.83  ?  447  LEU   C C     1 
ATOM   2369 O O     . LEU   A 1 447  ? 193.450 116.322 173.639 1.00 84.40  ?  447  LEU   C O     1 
ATOM   2370 C CB    . LEU   A 1 447  ? 190.431 115.290 174.051 1.00 68.76  ?  447  LEU   C CB    1 
ATOM   2371 C CG    . LEU   A 1 447  ? 188.974 115.731 174.154 1.00 68.84  ?  447  LEU   C CG    1 
ATOM   2372 C CD1   . LEU   A 1 447  ? 188.298 114.926 175.231 1.00 70.08  ?  447  LEU   C CD1   1 
ATOM   2373 C CD2   . LEU   A 1 447  ? 188.899 117.208 174.461 1.00 71.14  ?  447  LEU   C CD2   1 
ATOM   2374 N N     . SER   A 1 448  ? 193.094 114.394 172.551 1.00 74.88  ?  448  SER   C N     1 
ATOM   2375 C CA    . SER   A 1 448  ? 194.482 113.983 172.639 1.00 85.16  ?  448  SER   C CA    1 
ATOM   2376 C C     . SER   A 1 448  ? 195.379 114.973 171.922 1.00 87.66  ?  448  SER   C C     1 
ATOM   2377 O O     . SER   A 1 448  ? 196.357 115.462 172.488 1.00 93.77  ?  448  SER   C O     1 
ATOM   2378 C CB    . SER   A 1 448  ? 194.650 112.607 172.036 1.00 86.55  ?  448  SER   C CB    1 
ATOM   2379 O OG    . SER   A 1 448  ? 195.989 112.220 172.040 1.00 101.31 ?  448  SER   C OG    1 
ATOM   2380 N N     . SER   A 1 449  ? 195.020 115.305 170.686 1.00 83.41  ?  449  SER   C N     1 
ATOM   2381 C CA    . SER   A 1 449  ? 195.810 116.240 169.900 1.00 88.86  ?  449  SER   C CA    1 
ATOM   2382 C C     . SER   A 1 449  ? 195.752 117.648 170.481 1.00 88.24  ?  449  SER   C C     1 
ATOM   2383 O O     . SER   A 1 449  ? 196.735 118.384 170.443 1.00 93.59  ?  449  SER   C O     1 
ATOM   2384 C CB    . SER   A 1 449  ? 195.321 116.255 168.464 1.00 86.50  ?  449  SER   C CB    1 
ATOM   2385 O OG    . SER   A 1 449  ? 195.572 115.028 167.832 1.00 80.13  ?  449  SER   C OG    1 
ATOM   2386 N N     . LEU   A 1 450  ? 194.592 118.022 171.014 1.00 85.98  ?  450  LEU   C N     1 
ATOM   2387 C CA    . LEU   A 1 450  ? 194.404 119.354 171.571 1.00 90.57  ?  450  LEU   C CA    1 
ATOM   2388 C C     . LEU   A 1 450  ? 195.156 119.565 172.886 1.00 93.60  ?  450  LEU   C C     1 
ATOM   2389 O O     . LEU   A 1 450  ? 195.787 120.605 173.083 1.00 98.43  ?  450  LEU   C O     1 
ATOM   2390 C CB    . LEU   A 1 450  ? 192.903 119.617 171.773 1.00 86.77  ?  450  LEU   C CB    1 
ATOM   2391 C CG    . LEU   A 1 450  ? 192.501 121.069 172.126 1.00 90.96  ?  450  LEU   C CG    1 
ATOM   2392 C CD1   . LEU   A 1 450  ? 191.163 121.382 171.470 1.00 85.01  ?  450  LEU   C CD1   1 
ATOM   2393 C CD2   . LEU   A 1 450  ? 192.386 121.235 173.636 1.00 90.62  ?  450  LEU   C CD2   1 
ATOM   2394 N N     . LEU   A 1 451  ? 195.062 118.609 173.806 1.00 91.42  ?  451  LEU   C N     1 
ATOM   2395 C CA    . LEU   A 1 451  ? 195.624 118.780 175.141 1.00 96.53  ?  451  LEU   C CA    1 
ATOM   2396 C C     . LEU   A 1 451  ? 197.065 118.309 175.271 1.00 108.56 ?  451  LEU   C C     1 
ATOM   2397 O O     . LEU   A 1 451  ? 197.816 118.840 176.087 1.00 110.07 ?  451  LEU   C O     1 
ATOM   2398 C CB    . LEU   A 1 451  ? 194.756 118.038 176.169 1.00 97.23  ?  451  LEU   C CB    1 
ATOM   2399 C CG    . LEU   A 1 451  ? 193.295 118.534 176.329 1.00 94.28  ?  451  LEU   C CG    1 
ATOM   2400 C CD1   . LEU   A 1 451  ? 192.540 117.568 177.232 1.00 98.63  ?  451  LEU   C CD1   1 
ATOM   2401 C CD2   . LEU   A 1 451  ? 193.283 119.935 176.937 1.00 98.23  ?  451  LEU   C CD2   1 
ATOM   2402 N N     . GLN   A 1 452  ? 197.474 117.316 174.492 1.00 101.69 ?  452  GLN   C N     1 
ATOM   2403 C CA    . GLN   A 1 452  ? 198.833 116.799 174.631 1.00 112.49 ?  452  GLN   C CA    1 
ATOM   2404 C C     . GLN   A 1 452  ? 199.970 117.845 174.478 1.00 114.73 ?  452  GLN   C C     1 
ATOM   2405 O O     . GLN   A 1 452  ? 200.918 117.785 175.261 1.00 119.83 ?  452  GLN   C O     1 
ATOM   2406 C CB    . GLN   A 1 452  ? 199.072 115.628 173.670 1.00 112.31 ?  452  GLN   C CB    1 
ATOM   2407 C CG    . GLN   A 1 452  ? 200.444 114.978 173.814 1.00 124.52 ?  452  GLN   C CG    1 
ATOM   2408 C CD    . GLN   A 1 452  ? 200.630 114.339 175.184 1.00 127.30 ?  452  GLN   C CD    1 
ATOM   2409 O OE1   . GLN   A 1 452  ? 199.678 113.788 175.754 1.00 127.87 ?  452  GLN   C OE1   1 
ATOM   2410 N NE2   . GLN   A 1 452  ? 201.846 114.411 175.717 1.00 125.22 ?  452  GLN   C NE2   1 
ATOM   2411 N N     . PRO   A 1 453  ? 199.938 118.793 173.484 1.00 114.63 ?  453  PRO   C N     1 
ATOM   2412 C CA    . PRO   A 1 453  ? 200.967 119.801 173.228 1.00 120.61 ?  453  PRO   C CA    1 
ATOM   2413 C C     . PRO   A 1 453  ? 201.251 120.658 174.458 1.00 121.95 ?  453  PRO   C C     1 
ATOM   2414 O O     . PRO   A 1 453  ? 202.151 121.501 174.442 1.00 117.64 ?  453  PRO   C O     1 
ATOM   2415 C CB    . PRO   A 1 453  ? 200.352 120.638 172.087 1.00 118.36 ?  453  PRO   C CB    1 
ATOM   2416 C CG    . PRO   A 1 453  ? 199.414 119.686 171.386 1.00 114.11 ?  453  PRO   C CG    1 
ATOM   2417 C CD    . PRO   A 1 453  ? 198.815 118.859 172.499 1.00 110.04 ?  453  PRO   C CD    1 
ATOM   2418 N N     . LEU   A 1 462  ? 197.754 121.778 181.006 1.00 125.58 ?  462  LEU   C N     1 
ATOM   2419 C CA    . LEU   A 1 462  ? 197.142 121.145 179.844 1.00 120.71 ?  462  LEU   C CA    1 
ATOM   2420 C C     . LEU   A 1 462  ? 196.077 120.133 180.282 1.00 114.96 ?  462  LEU   C C     1 
ATOM   2421 O O     . LEU   A 1 462  ? 194.880 120.383 180.119 1.00 117.59 ?  462  LEU   C O     1 
ATOM   2422 C CB    . LEU   A 1 462  ? 198.226 120.463 178.968 1.00 121.03 ?  462  LEU   C CB    1 
ATOM   2423 C CG    . LEU   A 1 462  ? 199.241 121.410 178.203 1.00 125.24 ?  462  LEU   C CG    1 
ATOM   2424 C CD1   . LEU   A 1 462  ? 200.401 120.552 177.638 1.00 120.19 ?  462  LEU   C CD1   1 
ATOM   2425 C CD2   . LEU   A 1 462  ? 198.507 122.160 177.046 1.00 120.13 ?  462  LEU   C CD2   1 
ATOM   2426 N N     . CYS   A 1 463  ? 196.523 118.991 180.831 1.00 123.95 ?  463  CYS   C N     1 
ATOM   2427 C CA    . CYS   A 1 463  ? 195.648 117.912 181.293 1.00 114.16 ?  463  CYS   C CA    1 
ATOM   2428 C C     . CYS   A 1 463  ? 195.693 117.748 182.808 1.00 111.65 ?  463  CYS   C C     1 
ATOM   2429 O O     . CYS   A 1 463  ? 194.982 116.918 183.370 1.00 113.68 ?  463  CYS   C O     1 
ATOM   2430 C CB    . CYS   A 1 463  ? 196.048 116.596 180.634 1.00 122.45 ?  463  CYS   C CB    1 
ATOM   2431 S SG    . CYS   A 1 463  ? 197.685 116.006 181.119 1.00 135.29 ?  463  CYS   C SG    1 
ATOM   2432 N N     . ALA   A 1 464  ? 196.535 118.530 183.475 1.00 119.00 ?  464  ALA   C N     1 
ATOM   2433 C CA    . ALA   A 1 464  ? 196.700 118.403 184.920 1.00 111.92 ?  464  ALA   C CA    1 
ATOM   2434 C C     . ALA   A 1 464  ? 195.377 118.649 185.636 1.00 110.74 ?  464  ALA   C C     1 
ATOM   2435 O O     . ALA   A 1 464  ? 195.076 118.018 186.649 1.00 112.70 ?  464  ALA   C O     1 
ATOM   2436 C CB    . ALA   A 1 464  ? 197.759 119.372 185.416 1.00 108.60 ?  464  ALA   C CB    1 
ATOM   2437 N N     . HIS   A 1 465  ? 194.580 119.556 185.088 1.00 109.94 ?  465  HIS   C N     1 
ATOM   2438 C CA    . HIS   A 1 465  ? 193.282 119.907 185.640 1.00 106.89 ?  465  HIS   C CA    1 
ATOM   2439 C C     . HIS   A 1 465  ? 192.139 119.168 184.953 1.00 101.45 ?  465  HIS   C C     1 
ATOM   2440 O O     . HIS   A 1 465  ? 190.970 119.515 185.138 1.00 100.99 ?  465  HIS   C O     1 
ATOM   2441 C CB    . HIS   A 1 465  ? 193.063 121.409 185.525 1.00 109.53 ?  465  HIS   C CB    1 
ATOM   2442 C CG    . HIS   A 1 465  ? 193.231 121.896 184.138 1.00 112.36 ?  465  HIS   C CG    1 
ATOM   2443 N ND1   . HIS   A 1 465  ? 194.470 122.009 183.543 1.00 115.67 ?  465  HIS   C ND1   1 
ATOM   2444 C CD2   . HIS   A 1 465  ? 192.333 122.295 183.212 1.00 115.94 ?  465  HIS   C CD2   1 
ATOM   2445 C CE1   . HIS   A 1 465  ? 194.323 122.461 182.312 1.00 115.67 ?  465  HIS   C CE1   1 
ATOM   2446 N NE2   . HIS   A 1 465  ? 193.040 122.644 182.088 1.00 115.56 ?  465  HIS   C NE2   1 
ATOM   2447 N N     . LEU   A 1 466  ? 192.467 118.153 184.156 1.00 105.22 ?  466  LEU   C N     1 
ATOM   2448 C CA    . LEU   A 1 466  ? 191.448 117.407 183.437 1.00 100.72 ?  466  LEU   C CA    1 
ATOM   2449 C C     . LEU   A 1 466  ? 190.427 116.803 184.385 1.00 92.65  ?  466  LEU   C C     1 
ATOM   2450 O O     . LEU   A 1 466  ? 189.246 116.714 184.050 1.00 91.43  ?  466  LEU   C O     1 
ATOM   2451 C CB    . LEU   A 1 466  ? 192.083 116.297 182.592 1.00 101.65 ?  466  LEU   C CB    1 
ATOM   2452 C CG    . LEU   A 1 466  ? 191.108 115.417 181.782 1.00 99.63  ?  466  LEU   C CG    1 
ATOM   2453 C CD1   . LEU   A 1 466  ? 190.290 116.284 180.822 1.00 91.31  ?  466  LEU   C CD1   1 
ATOM   2454 C CD2   . LEU   A 1 466  ? 191.910 114.386 181.013 1.00 103.85 ?  466  LEU   C CD2   1 
ATOM   2455 N N     . TRP   A 1 467  ? 190.876 116.371 185.561 1.00 94.05  ?  467  TRP   C N     1 
ATOM   2456 C CA    . TRP   A 1 467  ? 189.959 115.790 186.532 1.00 93.79  ?  467  TRP   C CA    1 
ATOM   2457 C C     . TRP   A 1 467  ? 188.910 116.824 186.914 1.00 89.14  ?  467  TRP   C C     1 
ATOM   2458 O O     . TRP   A 1 467  ? 187.719 116.518 186.984 1.00 88.06  ?  467  TRP   C O     1 
ATOM   2459 C CB    . TRP   A 1 467  ? 190.708 115.333 187.786 1.00 95.50  ?  467  TRP   C CB    1 
ATOM   2460 C CG    . TRP   A 1 467  ? 189.869 114.496 188.715 1.00 98.20  ?  467  TRP   C CG    1 
ATOM   2461 C CD1   . TRP   A 1 467  ? 189.799 113.136 188.718 1.00 100.78 ?  467  TRP   C CD1   1 
ATOM   2462 C CD2   . TRP   A 1 467  ? 188.978 114.942 189.771 1.00 99.93  ?  467  TRP   C CD2   1 
ATOM   2463 N NE1   . TRP   A 1 467  ? 188.936 112.706 189.690 1.00 100.93 ?  467  TRP   C NE1   1 
ATOM   2464 C CE2   . TRP   A 1 467  ? 188.421 113.794 190.343 1.00 101.89 ?  467  TRP   C CE2   1 
ATOM   2465 C CE3   . TRP   A 1 467  ? 188.607 116.201 190.262 1.00 101.04 ?  467  TRP   C CE3   1 
ATOM   2466 C CZ2   . TRP   A 1 467  ? 187.519 113.860 191.393 1.00 102.88 ?  467  TRP   C CZ2   1 
ATOM   2467 C CZ3   . TRP   A 1 467  ? 187.699 116.265 191.314 1.00 104.13 ?  467  TRP   C CZ3   1 
ATOM   2468 C CH2   . TRP   A 1 467  ? 187.168 115.124 191.862 1.00 103.63 ?  467  TRP   C CH2   1 
ATOM   2469 N N     . GLY   A 1 468  ? 189.360 118.053 187.166 1.00 88.27  ?  468  GLY   C N     1 
ATOM   2470 C CA    . GLY   A 1 468  ? 188.468 119.140 187.542 1.00 90.54  ?  468  GLY   C CA    1 
ATOM   2471 C C     . GLY   A 1 468  ? 187.477 119.440 186.428 1.00 88.72  ?  468  GLY   C C     1 
ATOM   2472 O O     . GLY   A 1 468  ? 186.293 119.661 186.683 1.00 86.35  ?  468  GLY   C O     1 
ATOM   2473 N N     . LEU   A 1 469  ? 187.954 119.411 185.186 1.00 88.56  ?  469  LEU   C N     1 
ATOM   2474 C CA    . LEU   A 1 469  ? 187.081 119.650 184.044 1.00 81.06  ?  469  LEU   C CA    1 
ATOM   2475 C C     . LEU   A 1 469  ? 186.035 118.554 183.940 1.00 81.17  ?  469  LEU   C C     1 
ATOM   2476 O O     . LEU   A 1 469  ? 184.860 118.825 183.677 1.00 79.34  ?  469  LEU   C O     1 
ATOM   2477 C CB    . LEU   A 1 469  ? 187.885 119.708 182.740 1.00 84.04  ?  469  LEU   C CB    1 
ATOM   2478 C CG    . LEU   A 1 469  ? 187.067 119.954 181.445 1.00 81.35  ?  469  LEU   C CG    1 
ATOM   2479 C CD1   . LEU   A 1 469  ? 186.337 121.299 181.535 1.00 85.85  ?  469  LEU   C CD1   1 
ATOM   2480 C CD2   . LEU   A 1 469  ? 188.010 119.927 180.250 1.00 84.86  ?  469  LEU   C CD2   1 
ATOM   2481 N N     . CYS   A 1 470  ? 186.462 117.315 184.143 1.00 84.45  ?  470  CYS   C N     1 
ATOM   2482 C CA    . CYS   A 1 470  ? 185.553 116.185 184.077 1.00 83.26  ?  470  CYS   C CA    1 
ATOM   2483 C C     . CYS   A 1 470  ? 184.514 116.294 185.182 1.00 83.98  ?  470  CYS   C C     1 
ATOM   2484 O O     . CYS   A 1 470  ? 183.329 116.036 184.960 1.00 80.51  ?  470  CYS   C O     1 
ATOM   2485 C CB    . CYS   A 1 470  ? 186.322 114.876 184.207 1.00 90.74  ?  470  CYS   C CB    1 
ATOM   2486 S SG    . CYS   A 1 470  ? 187.398 114.528 182.806 1.00 92.07  ?  470  CYS   C SG    1 
ATOM   2487 N N     . SER   A 1 471  ? 184.956 116.717 186.364 1.00 83.45  ?  471  SER   C N     1 
ATOM   2488 C CA    . SER   A 1 471  ? 184.061 116.913 187.492 1.00 90.74  ?  471  SER   C CA    1 
ATOM   2489 C C     . SER   A 1 471  ? 183.040 117.991 187.172 1.00 81.50  ?  471  SER   C C     1 
ATOM   2490 O O     . SER   A 1 471  ? 181.850 117.825 187.438 1.00 78.83  ?  471  SER   C O     1 
ATOM   2491 C CB    . SER   A 1 471  ? 184.848 117.294 188.729 1.00 91.15  ?  471  SER   C CB    1 
ATOM   2492 O OG    . SER   A 1 471  ? 184.000 117.457 189.831 1.00 96.05  ?  471  SER   C OG    1 
ATOM   2493 N N     . LEU   A 1 472  ? 183.499 119.087 186.572 1.00 81.31  ?  472  LEU   C N     1 
ATOM   2494 C CA    . LEU   A 1 472  ? 182.607 120.172 186.191 1.00 79.92  ?  472  LEU   C CA    1 
ATOM   2495 C C     . LEU   A 1 472  ? 181.513 119.660 185.268 1.00 76.52  ?  472  LEU   C C     1 
ATOM   2496 O O     . LEU   A 1 472  ? 180.332 119.941 185.471 1.00 79.73  ?  472  LEU   C O     1 
ATOM   2497 C CB    . LEU   A 1 472  ? 183.391 121.277 185.465 1.00 83.18  ?  472  LEU   C CB    1 
ATOM   2498 C CG    . LEU   A 1 472  ? 182.576 122.494 184.971 1.00 82.61  ?  472  LEU   C CG    1 
ATOM   2499 C CD1   . LEU   A 1 472  ? 182.062 123.289 186.167 1.00 88.12  ?  472  LEU   C CD1   1 
ATOM   2500 C CD2   . LEU   A 1 472  ? 183.451 123.349 184.070 1.00 82.36  ?  472  LEU   C CD2   1 
ATOM   2501 N N     . ALA   A 1 473  ? 181.910 118.903 184.247 1.00 75.51  ?  473  ALA   C N     1 
ATOM   2502 C CA    . ALA   A 1 473  ? 180.936 118.374 183.304 1.00 71.97  ?  473  ALA   C CA    1 
ATOM   2503 C C     . ALA   A 1 473  ? 179.968 117.434 183.997 1.00 71.58  ?  473  ALA   C C     1 
ATOM   2504 O O     . ALA   A 1 473  ? 178.757 117.510 183.766 1.00 70.62  ?  473  ALA   C O     1 
ATOM   2505 C CB    . ALA   A 1 473  ? 181.644 117.637 182.185 1.00 71.67  ?  473  ALA   C CB    1 
ATOM   2506 N N     . ALA   A 1 474  ? 180.485 116.563 184.859 1.00 74.79  ?  474  ALA   C N     1 
ATOM   2507 C CA    . ALA   A 1 474  ? 179.653 115.602 185.565 1.00 77.07  ?  474  ALA   C CA    1 
ATOM   2508 C C     . ALA   A 1 474  ? 178.667 116.317 186.471 1.00 76.30  ?  474  ALA   C C     1 
ATOM   2509 O O     . ALA   A 1 474  ? 177.502 115.929 186.567 1.00 74.91  ?  474  ALA   C O     1 
ATOM   2510 C CB    . ALA   A 1 474  ? 180.513 114.645 186.372 1.00 80.50  ?  474  ALA   C CB    1 
ATOM   2511 N N     . ASP   A 1 475  ? 179.130 117.386 187.111 1.00 76.35  ?  475  ASP   C N     1 
ATOM   2512 C CA    . ASP   A 1 475  ? 178.277 118.158 187.996 1.00 76.65  ?  475  ASP   C CA    1 
ATOM   2513 C C     . ASP   A 1 475  ? 177.160 118.786 187.188 1.00 75.07  ?  475  ASP   C C     1 
ATOM   2514 O O     . ASP   A 1 475  ? 175.996 118.738 187.585 1.00 75.38  ?  475  ASP   C O     1 
ATOM   2515 C CB    . ASP   A 1 475  ? 179.085 119.253 188.702 1.00 82.96  ?  475  ASP   C CB    1 
ATOM   2516 C CG    . ASP   A 1 475  ? 178.335 119.920 189.856 1.00 87.67  ?  475  ASP   C CG    1 
ATOM   2517 O OD1   . ASP   A 1 475  ? 178.349 119.379 190.938 1.00 85.69  ?  475  ASP   C OD1   1 
ATOM   2518 O OD2   . ASP   A 1 475  ? 177.734 120.949 189.641 1.00 87.40  -1 475  ASP   C OD2   1 
ATOM   2519 N N     . GLY   A 1 476  ? 177.507 119.348 186.035 1.00 75.85  ?  476  GLY   C N     1 
ATOM   2520 C CA    . GLY   A 1 476  ? 176.522 119.985 185.174 1.00 76.06  ?  476  GLY   C CA    1 
ATOM   2521 C C     . GLY   A 1 476  ? 175.454 119.005 184.703 1.00 71.08  ?  476  GLY   C C     1 
ATOM   2522 O O     . GLY   A 1 476  ? 174.279 119.358 184.593 1.00 69.80  ?  476  GLY   C O     1 
ATOM   2523 N N     . ILE   A 1 477  ? 175.849 117.769 184.428 1.00 69.06  ?  477  ILE   C N     1 
ATOM   2524 C CA    . ILE   A 1 477  ? 174.877 116.785 183.980 1.00 67.86  ?  477  ILE   C CA    1 
ATOM   2525 C C     . ILE   A 1 477  ? 173.902 116.422 185.094 1.00 71.71  ?  477  ILE   C C     1 
ATOM   2526 O O     . ILE   A 1 477  ? 172.694 116.360 184.866 1.00 70.73  ?  477  ILE   C O     1 
ATOM   2527 C CB    . ILE   A 1 477  ? 175.574 115.514 183.450 1.00 65.94  ?  477  ILE   C CB    1 
ATOM   2528 C CG1   . ILE   A 1 477  ? 176.409 115.828 182.166 1.00 64.85  ?  477  ILE   C CG1   1 
ATOM   2529 C CG2   . ILE   A 1 477  ? 174.550 114.423 183.176 1.00 63.56  ?  477  ILE   C CG2   1 
ATOM   2530 C CD1   . ILE   A 1 477  ? 175.613 116.334 180.970 1.00 60.75  ?  477  ILE   C CD1   1 
ATOM   2531 N N     . TRP   A 1 478  ? 174.420 116.191 186.297 1.00 73.21  ?  478  TRP   C N     1 
ATOM   2532 C CA    . TRP   A 1 478  ? 173.574 115.801 187.420 1.00 73.29  ?  478  TRP   C CA    1 
ATOM   2533 C C     . TRP   A 1 478  ? 172.774 116.955 188.033 1.00 74.22  ?  478  TRP   C C     1 
ATOM   2534 O O     . TRP   A 1 478  ? 171.668 116.746 188.531 1.00 74.46  ?  478  TRP   C O     1 
ATOM   2535 C CB    . TRP   A 1 478  ? 174.424 115.137 188.502 1.00 77.03  ?  478  TRP   C CB    1 
ATOM   2536 C CG    . TRP   A 1 478  ? 174.832 113.743 188.151 1.00 75.22  ?  478  TRP   C CG    1 
ATOM   2537 C CD1   . TRP   A 1 478  ? 176.079 113.311 187.828 1.00 79.90  ?  478  TRP   C CD1   1 
ATOM   2538 C CD2   . TRP   A 1 478  ? 173.980 112.584 188.081 1.00 73.56  ?  478  TRP   C CD2   1 
ATOM   2539 N NE1   . TRP   A 1 478  ? 176.060 111.970 187.566 1.00 79.52  ?  478  TRP   C NE1   1 
ATOM   2540 C CE2   . TRP   A 1 478  ? 174.786 111.509 187.716 1.00 78.76  ?  478  TRP   C CE2   1 
ATOM   2541 C CE3   . TRP   A 1 478  ? 172.619 112.373 188.299 1.00 74.55  ?  478  TRP   C CE3   1 
ATOM   2542 C CZ2   . TRP   A 1 478  ? 174.279 110.242 187.553 1.00 81.12  ?  478  TRP   C CZ2   1 
ATOM   2543 C CZ3   . TRP   A 1 478  ? 172.108 111.093 188.134 1.00 76.27  ?  478  TRP   C CZ3   1 
ATOM   2544 C CH2   . TRP   A 1 478  ? 172.916 110.059 187.771 1.00 78.62  ?  478  TRP   C CH2   1 
ATOM   2545 N N     . ASN   A 1 479  ? 173.325 118.167 187.996 1.00 72.13  ?  479  ASN   C N     1 
ATOM   2546 C CA    . ASN   A 1 479  ? 172.669 119.322 188.606 1.00 69.61  ?  479  ASN   C CA    1 
ATOM   2547 C C     . ASN   A 1 479  ? 171.940 120.187 187.589 1.00 68.99  ?  479  ASN   C C     1 
ATOM   2548 O O     . ASN   A 1 479  ? 171.516 121.299 187.902 1.00 69.54  ?  479  ASN   C O     1 
ATOM   2549 C CB    . ASN   A 1 479  ? 173.664 120.157 189.385 1.00 73.93  ?  479  ASN   C CB    1 
ATOM   2550 C CG    . ASN   A 1 479  ? 174.161 119.457 190.607 1.00 76.35  ?  479  ASN   C CG    1 
ATOM   2551 O OD1   . ASN   A 1 479  ? 173.426 118.694 191.249 1.00 72.28  ?  479  ASN   C OD1   1 
ATOM   2552 N ND2   . ASN   A 1 479  ? 175.392 119.699 190.953 1.00 81.95  ?  479  ASN   C ND2   1 
ATOM   2553 N N     . GLN   A 1 480  ? 171.772 119.663 186.382 1.00 69.09  ?  480  GLN   C N     1 
ATOM   2554 C CA    . GLN   A 1 480  ? 171.038 120.351 185.327 1.00 67.55  ?  480  GLN   C CA    1 
ATOM   2555 C C     . GLN   A 1 480  ? 171.596 121.736 185.001 1.00 64.89  ?  480  GLN   C C     1 
ATOM   2556 O O     . GLN   A 1 480  ? 170.878 122.734 185.067 1.00 66.61  ?  480  GLN   C O     1 
ATOM   2557 C CB    . GLN   A 1 480  ? 169.563 120.463 185.717 1.00 65.93  ?  480  GLN   C CB    1 
ATOM   2558 C CG    . GLN   A 1 480  ? 168.901 119.123 185.954 1.00 69.22  ?  480  GLN   C CG    1 
ATOM   2559 C CD    . GLN   A 1 480  ? 167.457 119.244 186.367 1.00 73.82  ?  480  GLN   C CD    1 
ATOM   2560 O OE1   . GLN   A 1 480  ? 167.081 120.124 187.147 1.00 75.15  ?  480  GLN   C OE1   1 
ATOM   2561 N NE2   . GLN   A 1 480  ? 166.628 118.351 185.847 1.00 70.51  ?  480  GLN   C NE2   1 
ATOM   2562 N N     . LYS   A 1 481  ? 172.882 121.795 184.669 1.00 64.62  ?  481  LYS   C N     1 
ATOM   2563 C CA    . LYS   A 1 481  ? 173.516 123.051 184.293 1.00 67.20  ?  481  LYS   C CA    1 
ATOM   2564 C C     . LYS   A 1 481  ? 174.358 122.916 183.029 1.00 65.87  ?  481  LYS   C C     1 
ATOM   2565 O O     . LYS   A 1 481  ? 175.273 122.090 182.960 1.00 68.87  ?  481  LYS   C O     1 
ATOM   2566 C CB    . LYS   A 1 481  ? 174.399 123.572 185.426 1.00 72.97  ?  481  LYS   C CB    1 
ATOM   2567 C CG    . LYS   A 1 481  ? 173.651 124.005 186.678 1.00 75.43  ?  481  LYS   C CG    1 
ATOM   2568 C CD    . LYS   A 1 481  ? 174.610 124.419 187.787 1.00 79.65  ?  481  LYS   C CD    1 
ATOM   2569 C CE    . LYS   A 1 481  ? 175.343 125.714 187.443 1.00 87.73  ?  481  LYS   C CE    1 
ATOM   2570 N NZ    . LYS   A 1 481  ? 176.106 126.243 188.598 1.00 94.13  1  481  LYS   C NZ    1 
ATOM   2571 N N     . ILE   A 1 482  ? 174.068 123.762 182.046 1.00 60.78  ?  482  ILE   C N     1 
ATOM   2572 C CA    . ILE   A 1 482  ? 174.861 123.817 180.824 1.00 61.25  ?  482  ILE   C CA    1 
ATOM   2573 C C     . ILE   A 1 482  ? 175.774 125.031 180.855 1.00 69.61  ?  482  ILE   C C     1 
ATOM   2574 O O     . ILE   A 1 482  ? 176.926 124.969 180.429 1.00 74.63  ?  482  ILE   C O     1 
ATOM   2575 C CB    . ILE   A 1 482  ? 173.983 123.855 179.566 1.00 58.30  ?  482  ILE   C CB    1 
ATOM   2576 C CG1   . ILE   A 1 482  ? 173.150 122.575 179.487 1.00 60.04  ?  482  ILE   C CG1   1 
ATOM   2577 C CG2   . ILE   A 1 482  ? 174.888 123.985 178.330 1.00 62.13  ?  482  ILE   C CG2   1 
ATOM   2578 C CD1   . ILE   A 1 482  ? 172.063 122.602 178.425 1.00 58.12  ?  482  ILE   C CD1   1 
ATOM   2579 N N     . LEU   A 1 483  ? 175.229 126.151 181.319 1.00 69.31  ?  483  LEU   C N     1 
ATOM   2580 C CA    . LEU   A 1 483  ? 175.983 127.389 181.422 1.00 73.16  ?  483  LEU   C CA    1 
ATOM   2581 C C     . LEU   A 1 483  ? 176.608 127.486 182.799 1.00 77.83  ?  483  LEU   C C     1 
ATOM   2582 O O     . LEU   A 1 483  ? 175.953 127.201 183.801 1.00 80.23  ?  483  LEU   C O     1 
ATOM   2583 C CB    . LEU   A 1 483  ? 175.059 128.591 181.198 1.00 74.24  ?  483  LEU   C CB    1 
ATOM   2584 C CG    . LEU   A 1 483  ? 174.343 128.666 179.844 1.00 71.58  ?  483  LEU   C CG    1 
ATOM   2585 C CD1   . LEU   A 1 483  ? 173.410 129.864 179.848 1.00 74.15  ?  483  LEU   C CD1   1 
ATOM   2586 C CD2   . LEU   A 1 483  ? 175.365 128.784 178.725 1.00 75.69  ?  483  LEU   C CD2   1 
ATOM   2587 N N     . PHE   A 1 484  ? 177.859 127.916 182.852 1.00 79.74  ?  484  PHE   C N     1 
ATOM   2588 C CA    . PHE   A 1 484  ? 178.563 128.031 184.119 1.00 85.87  ?  484  PHE   C CA    1 
ATOM   2589 C C     . PHE   A 1 484  ? 178.996 129.458 184.394 1.00 91.71  ?  484  PHE   C C     1 
ATOM   2590 O O     . PHE   A 1 484  ? 179.328 130.210 183.477 1.00 92.44  ?  484  PHE   C O     1 
ATOM   2591 C CB    . PHE   A 1 484  ? 179.794 127.124 184.118 1.00 87.15  ?  484  PHE   C CB    1 
ATOM   2592 C CG    . PHE   A 1 484  ? 179.464 125.683 183.910 1.00 82.35  ?  484  PHE   C CG    1 
ATOM   2593 C CD1   . PHE   A 1 484  ? 179.587 125.113 182.657 1.00 76.04  ?  484  PHE   C CD1   1 
ATOM   2594 C CD2   . PHE   A 1 484  ? 179.018 124.895 184.957 1.00 87.41  ?  484  PHE   C CD2   1 
ATOM   2595 C CE1   . PHE   A 1 484  ? 179.276 123.789 182.453 1.00 77.31  ?  484  PHE   C CE1   1 
ATOM   2596 C CE2   . PHE   A 1 484  ? 178.707 123.565 184.756 1.00 81.91  ?  484  PHE   C CE2   1 
ATOM   2597 C CZ    . PHE   A 1 484  ? 178.838 123.013 183.501 1.00 79.54  ?  484  PHE   C CZ    1 
ATOM   2598 N N     . GLU   A 1 485  ? 179.042 129.814 185.670 1.00 97.15  ?  485  GLU   C N     1 
ATOM   2599 C CA    . GLU   A 1 485  ? 179.565 131.108 186.081 1.00 99.67  ?  485  GLU   C CA    1 
ATOM   2600 C C     . GLU   A 1 485  ? 181.022 130.954 186.481 1.00 102.62 ?  485  GLU   C C     1 
ATOM   2601 O O     . GLU   A 1 485  ? 181.475 129.849 186.781 1.00 100.37 ?  485  GLU   C O     1 
ATOM   2602 C CB    . GLU   A 1 485  ? 178.746 131.681 187.240 1.00 105.28 ?  485  GLU   C CB    1 
ATOM   2603 C CG    . GLU   A 1 485  ? 177.290 131.951 186.891 1.00 107.94 ?  485  GLU   C CG    1 
ATOM   2604 C CD    . GLU   A 1 485  ? 176.508 132.569 188.020 1.00 115.74 ?  485  GLU   C CD    1 
ATOM   2605 O OE1   . GLU   A 1 485  ? 177.081 132.808 189.055 1.00 107.81 ?  485  GLU   C OE1   1 
ATOM   2606 O OE2   . GLU   A 1 485  ? 175.334 132.800 187.846 1.00 107.51 -1 485  GLU   C OE2   1 
ATOM   2607 N N     . GLU   A 1 486  ? 181.757 132.055 186.525 1.00 104.70 ?  486  GLU   C N     1 
ATOM   2608 C CA    . GLU   A 1 486  ? 183.157 131.980 186.923 1.00 107.58 ?  486  GLU   C CA    1 
ATOM   2609 C C     . GLU   A 1 486  ? 183.285 131.424 188.335 1.00 114.42 ?  486  GLU   C C     1 
ATOM   2610 O O     . GLU   A 1 486  ? 184.291 130.799 188.670 1.00 107.03 ?  486  GLU   C O     1 
ATOM   2611 C CB    . GLU   A 1 486  ? 183.825 133.346 186.807 1.00 108.18 ?  486  GLU   C CB    1 
ATOM   2612 C CG    . GLU   A 1 486  ? 183.968 133.810 185.373 1.00 113.42 ?  486  GLU   C CG    1 
ATOM   2613 C CD    . GLU   A 1 486  ? 184.649 135.133 185.210 1.00 125.28 ?  486  GLU   C CD    1 
ATOM   2614 O OE1   . GLU   A 1 486  ? 184.811 135.827 186.184 1.00 124.13 ?  486  GLU   C OE1   1 
ATOM   2615 O OE2   . GLU   A 1 486  ? 185.015 135.450 184.095 1.00 120.65 -1 486  GLU   C OE2   1 
ATOM   2616 N N     . SER   A 1 487  ? 182.252 131.626 189.150 1.00 106.85 ?  487  SER   C N     1 
ATOM   2617 C CA    . SER   A 1 487  ? 182.223 131.088 190.503 1.00 110.93 ?  487  SER   C CA    1 
ATOM   2618 C C     . SER   A 1 487  ? 182.181 129.563 190.484 1.00 107.24 ?  487  SER   C C     1 
ATOM   2619 O O     . SER   A 1 487  ? 182.718 128.910 191.380 1.00 110.70 ?  487  SER   C O     1 
ATOM   2620 C CB    . SER   A 1 487  ? 181.016 131.623 191.252 1.00 111.12 ?  487  SER   C CB    1 
ATOM   2621 O OG    . SER   A 1 487  ? 181.116 133.008 191.454 1.00 112.52 ?  487  SER   C OG    1 
ATOM   2622 N N     . ASP   A 1 488  ? 181.560 128.990 189.453 1.00 105.07 ?  488  ASP   C N     1 
ATOM   2623 C CA    . ASP   A 1 488  ? 181.439 127.544 189.364 1.00 107.64 ?  488  ASP   C CA    1 
ATOM   2624 C C     . ASP   A 1 488  ? 182.754 126.963 188.896 1.00 101.84 ?  488  ASP   C C     1 
ATOM   2625 O O     . ASP   A 1 488  ? 183.131 125.855 189.279 1.00 109.49 ?  488  ASP   C O     1 
ATOM   2626 C CB    . ASP   A 1 488  ? 180.338 127.145 188.378 1.00 101.58 ?  488  ASP   C CB    1 
ATOM   2627 C CG    . ASP   A 1 488  ? 178.942 127.538 188.832 1.00 104.52 ?  488  ASP   C CG    1 
ATOM   2628 O OD1   . ASP   A 1 488  ? 178.573 127.213 189.938 1.00 103.20 ?  488  ASP   C OD1   1 
ATOM   2629 O OD2   . ASP   A 1 488  ? 178.232 128.135 188.047 1.00 103.28 -1 488  ASP   C OD2   1 
ATOM   2630 N N     . LEU   A 1 489  ? 183.463 127.720 188.070 1.00 106.08 ?  489  LEU   C N     1 
ATOM   2631 C CA    . LEU   A 1 489  ? 184.754 127.264 187.585 1.00 109.35 ?  489  LEU   C CA    1 
ATOM   2632 C C     . LEU   A 1 489  ? 185.777 127.314 188.717 1.00 100.28 ?  489  LEU   C C     1 
ATOM   2633 O O     . LEU   A 1 489  ? 186.538 126.366 188.924 1.00 108.56 ?  489  LEU   C O     1 
ATOM   2634 C CB    . LEU   A 1 489  ? 185.214 128.145 186.414 1.00 106.92 ?  489  LEU   C CB    1 
ATOM   2635 C CG    . LEU   A 1 489  ? 184.330 128.102 185.134 1.00 102.50 ?  489  LEU   C CG    1 
ATOM   2636 C CD1   . LEU   A 1 489  ? 184.812 129.163 184.155 1.00 103.87 ?  489  LEU   C CD1   1 
ATOM   2637 C CD2   . LEU   A 1 489  ? 184.401 126.720 184.499 1.00 100.15 ?  489  LEU   C CD2   1 
ATOM   2638 N N     . ARG   A 1 490  ? 185.746 128.391 189.501 1.00 163.74 ?  490  ARG   C N     1 
ATOM   2639 C CA    . ARG   A 1 490  ? 186.674 128.535 190.616 1.00 115.81 ?  490  ARG   C CA    1 
ATOM   2640 C C     . ARG   A 1 490  ? 186.485 127.422 191.637 1.00 115.53 ?  490  ARG   C C     1 
ATOM   2641 O O     . ARG   A 1 490  ? 187.454 126.910 192.200 1.00 112.61 ?  490  ARG   C O     1 
ATOM   2642 C CB    . ARG   A 1 490  ? 186.505 129.881 191.304 1.00 117.28 ?  490  ARG   C CB    1 
ATOM   2643 C CG    . ARG   A 1 490  ? 187.054 131.075 190.534 1.00 122.37 ?  490  ARG   C CG    1 
ATOM   2644 C CD    . ARG   A 1 490  ? 187.147 132.286 191.390 1.00 123.28 ?  490  ARG   C CD    1 
ATOM   2645 N NE    . ARG   A 1 490  ? 185.840 132.762 191.824 1.00 119.59 ?  490  ARG   C NE    1 
ATOM   2646 C CZ    . ARG   A 1 490  ? 185.067 133.644 191.152 1.00 120.90 ?  490  ARG   C CZ    1 
ATOM   2647 N NH1   . ARG   A 1 490  ? 185.468 134.154 190.006 1.00 117.71 1  490  ARG   C NH1   1 
ATOM   2648 N NH2   . ARG   A 1 490  ? 183.898 134.002 191.653 1.00 118.20 ?  490  ARG   C NH2   1 
ATOM   2649 N N     . ASN   A 1 491  ? 185.237 127.019 191.846 1.00 112.66 ?  491  ASN   C N     1 
ATOM   2650 C CA    . ASN   A 1 491  ? 184.912 125.992 192.825 1.00 115.36 ?  491  ASN   C CA    1 
ATOM   2651 C C     . ASN   A 1 491  ? 185.405 124.606 192.415 1.00 109.06 ?  491  ASN   C C     1 
ATOM   2652 O O     . ASN   A 1 491  ? 185.369 123.670 193.215 1.00 111.64 ?  491  ASN   C O     1 
ATOM   2653 C CB    . ASN   A 1 491  ? 183.422 125.971 193.085 1.00 114.74 ?  491  ASN   C CB    1 
ATOM   2654 C CG    . ASN   A 1 491  ? 182.963 127.169 193.872 1.00 119.04 ?  491  ASN   C CG    1 
ATOM   2655 O OD1   . ASN   A 1 491  ? 183.766 127.849 194.522 1.00 122.10 ?  491  ASN   C OD1   1 
ATOM   2656 N ND2   . ASN   A 1 491  ? 181.684 127.440 193.830 1.00 120.65 ?  491  ASN   C ND2   1 
ATOM   2657 N N     . HIS   A 1 492  ? 185.867 124.471 191.174 1.00 112.32 ?  492  HIS   C N     1 
ATOM   2658 C CA    . HIS   A 1 492  ? 186.412 123.208 190.695 1.00 108.77 ?  492  HIS   C CA    1 
ATOM   2659 C C     . HIS   A 1 492  ? 187.924 123.290 190.540 1.00 110.39 ?  492  HIS   C C     1 
ATOM   2660 O O     . HIS   A 1 492  ? 188.551 122.392 189.977 1.00 106.66 ?  492  HIS   C O     1 
ATOM   2661 C CB    . HIS   A 1 492  ? 185.765 122.800 189.368 1.00 104.67 ?  492  HIS   C CB    1 
ATOM   2662 C CG    . HIS   A 1 492  ? 184.349 122.334 189.512 1.00 101.96 ?  492  HIS   C CG    1 
ATOM   2663 N ND1   . HIS   A 1 492  ? 183.276 123.193 189.550 1.00 104.08 ?  492  HIS   C ND1   1 
ATOM   2664 C CD2   . HIS   A 1 492  ? 183.839 121.090 189.635 1.00 97.61  ?  492  HIS   C CD2   1 
ATOM   2665 C CE1   . HIS   A 1 492  ? 182.165 122.495 189.685 1.00 97.37  ?  492  HIS   C CE1   1 
ATOM   2666 N NE2   . HIS   A 1 492  ? 182.480 121.216 189.737 1.00 93.88  ?  492  HIS   C NE2   1 
ATOM   2667 N N     . GLY   A 1 493  ? 188.509 124.371 191.052 1.00 112.64 ?  493  GLY   C N     1 
ATOM   2668 C CA    . GLY   A 1 493  ? 189.948 124.573 190.972 1.00 114.73 ?  493  GLY   C CA    1 
ATOM   2669 C C     . GLY   A 1 493  ? 190.367 125.072 189.596 1.00 117.48 ?  493  GLY   C C     1 
ATOM   2670 O O     . GLY   A 1 493  ? 191.519 124.908 189.192 1.00 112.06 ?  493  GLY   C O     1 
ATOM   2671 N N     . LEU   A 1 494  ? 189.427 125.663 188.867 1.00 115.75 ?  494  LEU   C N     1 
ATOM   2672 C CA    . LEU   A 1 494  ? 189.693 126.151 187.527 1.00 117.20 ?  494  LEU   C CA    1 
ATOM   2673 C C     . LEU   A 1 494  ? 189.655 127.673 187.504 1.00 121.11 ?  494  LEU   C C     1 
ATOM   2674 O O     . LEU   A 1 494  ? 188.580 128.273 187.500 1.00 117.90 ?  494  LEU   C O     1 
ATOM   2675 C CB    . LEU   A 1 494  ? 188.641 125.583 186.570 1.00 113.77 ?  494  LEU   C CB    1 
ATOM   2676 C CG    . LEU   A 1 494  ? 188.485 124.040 186.561 1.00 108.75 ?  494  LEU   C CG    1 
ATOM   2677 C CD1   . LEU   A 1 494  ? 187.273 123.664 185.714 1.00 105.47 ?  494  LEU   C CD1   1 
ATOM   2678 C CD2   . LEU   A 1 494  ? 189.750 123.398 186.006 1.00 107.15 ?  494  LEU   C CD2   1 
ATOM   2679 N N     . GLN   A 1 495  ? 190.825 128.305 187.515 1.00 124.21 ?  495  GLN   C N     1 
ATOM   2680 C CA    . GLN   A 1 495  ? 190.874 129.759 187.592 1.00 130.22 ?  495  GLN   C CA    1 
ATOM   2681 C C     . GLN   A 1 495  ? 192.097 130.346 186.903 1.00 130.77 ?  495  GLN   C C     1 
ATOM   2682 O O     . GLN   A 1 495  ? 193.232 130.002 187.233 1.00 126.99 ?  495  GLN   C O     1 
ATOM   2683 C CB    . GLN   A 1 495  ? 190.846 130.193 189.060 1.00 131.12 ?  495  GLN   C CB    1 
ATOM   2684 C CG    . GLN   A 1 495  ? 190.820 131.691 189.281 1.00 133.39 ?  495  GLN   C CG    1 
ATOM   2685 C CD    . GLN   A 1 495  ? 190.673 132.043 190.746 1.00 136.61 ?  495  GLN   C CD    1 
ATOM   2686 O OE1   . GLN   A 1 495  ? 190.692 131.162 191.608 1.00 131.08 ?  495  GLN   C OE1   1 
ATOM   2687 N NE2   . GLN   A 1 495  ? 190.524 133.328 191.043 1.00 136.44 ?  495  GLN   C NE2   1 
ATOM   2688 N N     . LYS   A 1 496  ? 191.855 131.260 185.965 1.00 134.34 ?  496  LYS   C N     1 
ATOM   2689 C CA    . LYS   A 1 496  ? 192.918 131.975 185.259 1.00 133.71 ?  496  LYS   C CA    1 
ATOM   2690 C C     . LYS   A 1 496  ? 193.961 131.044 184.651 1.00 126.60 ?  496  LYS   C C     1 
ATOM   2691 O O     . LYS   A 1 496  ? 195.160 131.317 184.719 1.00 134.62 ?  496  LYS   C O     1 
ATOM   2692 C CB    . LYS   A 1 496  ? 193.605 132.973 186.194 1.00 141.72 ?  496  LYS   C CB    1 
ATOM   2693 C CG    . LYS   A 1 496  ? 192.711 134.102 186.685 1.00 142.08 ?  496  LYS   C CG    1 
ATOM   2694 C CD    . LYS   A 1 496  ? 193.485 135.062 187.574 1.00 145.93 ?  496  LYS   C CD    1 
ATOM   2695 C CE    . LYS   A 1 496  ? 192.595 136.178 188.103 1.00 153.25 ?  496  LYS   C CE    1 
ATOM   2696 N NZ    . LYS   A 1 496  ? 193.351 137.123 188.974 1.00 159.44 1  496  LYS   C NZ    1 
ATOM   2697 N N     . ALA   A 1 497  ? 193.506 129.951 184.048 1.00 129.04 ?  497  ALA   C N     1 
ATOM   2698 C CA    . ALA   A 1 497  ? 194.429 129.010 183.429 1.00 122.93 ?  497  ALA   C CA    1 
ATOM   2699 C C     . ALA   A 1 497  ? 193.761 128.209 182.321 1.00 117.57 ?  497  ALA   C C     1 
ATOM   2700 O O     . ALA   A 1 497  ? 194.183 128.254 181.163 1.00 120.23 ?  497  ALA   C O     1 
ATOM   2701 C CB    . ALA   A 1 497  ? 194.992 128.067 184.482 1.00 121.96 ?  497  ALA   C CB    1 
ATOM   2702 N N     . ASP   A 1 498  ? 192.756 127.425 182.695 1.00 120.25 ?  498  ASP   C N     1 
ATOM   2703 C CA    . ASP   A 1 498  ? 192.154 126.466 181.788 1.00 122.94 ?  498  ASP   C CA    1 
ATOM   2704 C C     . ASP   A 1 498  ? 191.332 127.160 180.727 1.00 114.99 ?  498  ASP   C C     1 
ATOM   2705 O O     . ASP   A 1 498  ? 191.374 126.794 179.554 1.00 104.30 ?  498  ASP   C O     1 
ATOM   2706 C CB    . ASP   A 1 498  ? 191.240 125.542 182.570 1.00 113.78 ?  498  ASP   C CB    1 
ATOM   2707 C CG    . ASP   A 1 498  ? 190.147 126.329 183.229 1.00 115.98 ?  498  ASP   C CG    1 
ATOM   2708 O OD1   . ASP   A 1 498  ? 190.428 127.434 183.664 1.00 119.90 ?  498  ASP   C OD1   1 
ATOM   2709 O OD2   . ASP   A 1 498  ? 189.036 125.862 183.262 1.00 119.44 -1 498  ASP   C OD2   1 
ATOM   2710 N N     . VAL   A 1 499  ? 190.605 128.188 181.136 1.00 108.30 ?  499  VAL   C N     1 
ATOM   2711 C CA    . VAL   A 1 499  ? 189.743 128.883 180.201 1.00 111.54 ?  499  VAL   C CA    1 
ATOM   2712 C C     . VAL   A 1 499  ? 190.563 129.454 179.065 1.00 105.17 ?  499  VAL   C C     1 
ATOM   2713 O O     . VAL   A 1 499  ? 190.198 129.297 177.906 1.00 108.76 ?  499  VAL   C O     1 
ATOM   2714 C CB    . VAL   A 1 499  ? 188.954 130.000 180.907 1.00 110.10 ?  499  VAL   C CB    1 
ATOM   2715 C CG1   . VAL   A 1 499  ? 188.235 130.875 179.883 1.00 109.79 ?  499  VAL   C CG1   1 
ATOM   2716 C CG2   . VAL   A 1 499  ? 187.940 129.369 181.854 1.00 108.12 ?  499  VAL   C CG2   1 
ATOM   2717 N N     . SER   A 1 500  ? 191.689 130.080 179.383 1.00 111.02 ?  500  SER   C N     1 
ATOM   2718 C CA    . SER   A 1 500  ? 192.532 130.641 178.339 1.00 110.56 ?  500  SER   C CA    1 
ATOM   2719 C C     . SER   A 1 500  ? 193.061 129.537 177.431 1.00 100.16 ?  500  SER   C C     1 
ATOM   2720 O O     . SER   A 1 500  ? 193.044 129.666 176.205 1.00 107.71 ?  500  SER   C O     1 
ATOM   2721 C CB    . SER   A 1 500  ? 193.691 131.398 178.955 1.00 118.78 ?  500  SER   C CB    1 
ATOM   2722 O OG    . SER   A 1 500  ? 193.245 132.518 179.668 1.00 113.65 ?  500  SER   C OG    1 
ATOM   2723 N N     . ALA   A 1 501  ? 193.490 128.429 178.031 1.00 113.32 ?  501  ALA   C N     1 
ATOM   2724 C CA    . ALA   A 1 501  ? 194.021 127.306 177.267 1.00 110.57 ?  501  ALA   C CA    1 
ATOM   2725 C C     . ALA   A 1 501  ? 192.978 126.745 176.310 1.00 103.32 ?  501  ALA   C C     1 
ATOM   2726 O O     . ALA   A 1 501  ? 193.304 126.313 175.203 1.00 105.93 ?  501  ALA   C O     1 
ATOM   2727 C CB    . ALA   A 1 501  ? 194.499 126.215 178.209 1.00 115.74 ?  501  ALA   C CB    1 
ATOM   2728 N N     . PHE   A 1 502  ? 191.720 126.770 176.736 1.00 109.31 ?  502  PHE   C N     1 
ATOM   2729 C CA    . PHE   A 1 502  ? 190.627 126.196 175.970 1.00 102.44 ?  502  PHE   C CA    1 
ATOM   2730 C C     . PHE   A 1 502  ? 190.067 127.177 174.952 1.00 89.76  ?  502  PHE   C C     1 
ATOM   2731 O O     . PHE   A 1 502  ? 189.121 126.860 174.227 1.00 98.77  ?  502  PHE   C O     1 
ATOM   2732 C CB    . PHE   A 1 502  ? 189.510 125.772 176.912 1.00 92.27  ?  502  PHE   C CB    1 
ATOM   2733 C CG    . PHE   A 1 502  ? 189.884 124.730 177.920 1.00 97.76  ?  502  PHE   C CG    1 
ATOM   2734 C CD1   . PHE   A 1 502  ? 189.104 124.564 179.049 1.00 99.46  ?  502  PHE   C CD1   1 
ATOM   2735 C CD2   . PHE   A 1 502  ? 191.004 123.917 177.763 1.00 102.48 ?  502  PHE   C CD2   1 
ATOM   2736 C CE1   . PHE   A 1 502  ? 189.419 123.618 179.988 1.00 104.09 ?  502  PHE   C CE1   1 
ATOM   2737 C CE2   . PHE   A 1 502  ? 191.321 122.973 178.710 1.00 109.04 ?  502  PHE   C CE2   1 
ATOM   2738 C CZ    . PHE   A 1 502  ? 190.527 122.823 179.820 1.00 107.65 ?  502  PHE   C CZ    1 
ATOM   2739 N N     . LEU   A 1 503  ? 190.651 128.369 174.892 1.00 99.66  ?  503  LEU   C N     1 
ATOM   2740 C CA    . LEU   A 1 503  ? 190.279 129.344 173.880 1.00 101.84 ?  503  LEU   C CA    1 
ATOM   2741 C C     . LEU   A 1 503  ? 191.384 129.432 172.839 1.00 105.03 ?  503  LEU   C C     1 
ATOM   2742 O O     . LEU   A 1 503  ? 191.115 129.588 171.649 1.00 101.40 ?  503  LEU   C O     1 
ATOM   2743 C CB    . LEU   A 1 503  ? 190.002 130.712 174.517 1.00 103.58 ?  503  LEU   C CB    1 
ATOM   2744 C CG    . LEU   A 1 503  ? 188.793 130.769 175.484 1.00 100.00 ?  503  LEU   C CG    1 
ATOM   2745 C CD1   . LEU   A 1 503  ? 188.745 132.131 176.152 1.00 107.97 ?  503  LEU   C CD1   1 
ATOM   2746 C CD2   . LEU   A 1 503  ? 187.503 130.507 174.723 1.00 93.01  ?  503  LEU   C CD2   1 
ATOM   2747 N N     . ARG   A 1 504  ? 192.637 129.284 173.278 1.00 106.82 ?  504  ARG   C N     1 
ATOM   2748 C CA    . ARG   A 1 504  ? 193.743 129.261 172.329 1.00 109.82 ?  504  ARG   C CA    1 
ATOM   2749 C C     . ARG   A 1 504  ? 193.548 128.076 171.394 1.00 106.44 ?  504  ARG   C C     1 
ATOM   2750 O O     . ARG   A 1 504  ? 193.667 128.201 170.175 1.00 105.01 ?  504  ARG   C O     1 
ATOM   2751 C CB    . ARG   A 1 504  ? 195.084 129.150 173.037 1.00 110.96 ?  504  ARG   C CB    1 
ATOM   2752 C CG    . ARG   A 1 504  ? 195.526 130.400 173.787 1.00 113.59 ?  504  ARG   C CG    1 
ATOM   2753 C CD    . ARG   A 1 504  ? 196.971 130.346 174.152 1.00 117.28 ?  504  ARG   C CD    1 
ATOM   2754 N NE    . ARG   A 1 504  ? 197.271 129.263 175.084 1.00 120.85 ?  504  ARG   C NE    1 
ATOM   2755 C CZ    . ARG   A 1 504  ? 197.222 129.354 176.432 1.00 122.04 ?  504  ARG   C CZ    1 
ATOM   2756 N NH1   . ARG   A 1 504  ? 196.879 130.482 177.017 1.00 118.79 1  504  ARG   C NH1   1 
ATOM   2757 N NH2   . ARG   A 1 504  ? 197.525 128.300 177.169 1.00 121.13 ?  504  ARG   C NH2   1 
ATOM   2758 N N     . MET   A 1 505  ? 193.182 126.936 171.976 1.00 105.41 ?  505  MET   C N     1 
ATOM   2759 C CA    . MET   A 1 505  ? 192.783 125.771 171.202 1.00 100.48 ?  505  MET   C CA    1 
ATOM   2760 C C     . MET   A 1 505  ? 191.359 125.411 171.592 1.00 93.56  ?  505  MET   C C     1 
ATOM   2761 O O     . MET   A 1 505  ? 191.121 124.811 172.639 1.00 92.74  ?  505  MET   C O     1 
ATOM   2762 C CB    . MET   A 1 505  ? 193.739 124.610 171.425 1.00 100.97 ?  505  MET   C CB    1 
ATOM   2763 C CG    . MET   A 1 505  ? 195.172 124.898 170.986 1.00 108.04 ?  505  MET   C CG    1 
ATOM   2764 S SD    . MET   A 1 505  ? 196.286 123.499 171.227 1.00 115.97 ?  505  MET   C SD    1 
ATOM   2765 C CE    . MET   A 1 505  ? 195.813 122.432 169.866 1.00 99.96  ?  505  MET   C CE    1 
ATOM   2766 N N     . ASN   A 1 506  ? 190.412 125.828 170.763 1.00 93.14  ?  506  ASN   C N     1 
ATOM   2767 C CA    . ASN   A 1 506  ? 188.998 125.763 171.104 1.00 86.78  ?  506  ASN   C CA    1 
ATOM   2768 C C     . ASN   A 1 506  ? 188.558 124.417 171.665 1.00 82.36  ?  506  ASN   C C     1 
ATOM   2769 O O     . ASN   A 1 506  ? 188.394 123.446 170.924 1.00 81.82  ?  506  ASN   C O     1 
ATOM   2770 C CB    . ASN   A 1 506  ? 188.157 126.104 169.891 1.00 86.13  ?  506  ASN   C CB    1 
ATOM   2771 C CG    . ASN   A 1 506  ? 186.705 126.162 170.210 1.00 85.94  ?  506  ASN   C CG    1 
ATOM   2772 O OD1   . ASN   A 1 506  ? 186.299 126.670 171.259 1.00 87.38  ?  506  ASN   C OD1   1 
ATOM   2773 N ND2   . ASN   A 1 506  ? 185.907 125.644 169.324 1.00 83.20  ?  506  ASN   C ND2   1 
ATOM   2774 N N     . LEU   A 1 507  ? 188.308 124.396 172.970 1.00 84.52  ?  507  LEU   C N     1 
ATOM   2775 C CA    . LEU   A 1 507  ? 187.730 123.248 173.657 1.00 81.55  ?  507  LEU   C CA    1 
ATOM   2776 C C     . LEU   A 1 507  ? 186.500 123.660 174.453 1.00 76.75  ?  507  LEU   C C     1 
ATOM   2777 O O     . LEU   A 1 507  ? 185.601 122.856 174.705 1.00 69.96  ?  507  LEU   C O     1 
ATOM   2778 C CB    . LEU   A 1 507  ? 188.745 122.588 174.594 1.00 84.94  ?  507  LEU   C CB    1 
ATOM   2779 C CG    . LEU   A 1 507  ? 188.200 121.406 175.428 1.00 79.57  ?  507  LEU   C CG    1 
ATOM   2780 C CD1   . LEU   A 1 507  ? 187.673 120.328 174.498 1.00 72.55  ?  507  LEU   C CD1   1 
ATOM   2781 C CD2   . LEU   A 1 507  ? 189.313 120.862 176.312 1.00 86.21  ?  507  LEU   C CD2   1 
ATOM   2782 N N     . PHE   A 1 508  ? 186.510 124.904 174.905 1.00 81.98  ?  508  PHE   C N     1 
ATOM   2783 C CA    . PHE   A 1 508  ? 185.513 125.421 175.833 1.00 79.75  ?  508  PHE   C CA    1 
ATOM   2784 C C     . PHE   A 1 508  ? 185.244 126.868 175.450 1.00 80.05  ?  508  PHE   C C     1 
ATOM   2785 O O     . PHE   A 1 508  ? 186.173 127.593 175.104 1.00 86.24  ?  508  PHE   C O     1 
ATOM   2786 C CB    . PHE   A 1 508  ? 186.060 125.294 177.258 1.00 80.80  ?  508  PHE   C CB    1 
ATOM   2787 C CG    . PHE   A 1 508  ? 185.102 125.489 178.372 1.00 75.69  ?  508  PHE   C CG    1 
ATOM   2788 C CD1   . PHE   A 1 508  ? 184.159 124.521 178.670 1.00 76.17  ?  508  PHE   C CD1   1 
ATOM   2789 C CD2   . PHE   A 1 508  ? 185.170 126.616 179.162 1.00 80.87  ?  508  PHE   C CD2   1 
ATOM   2790 C CE1   . PHE   A 1 508  ? 183.293 124.684 179.729 1.00 77.77  ?  508  PHE   C CE1   1 
ATOM   2791 C CE2   . PHE   A 1 508  ? 184.314 126.780 180.218 1.00 86.41  ?  508  PHE   C CE2   1 
ATOM   2792 C CZ    . PHE   A 1 508  ? 183.367 125.814 180.504 1.00 83.90  ?  508  PHE   C CZ    1 
ATOM   2793 N N     . GLN   A 1 509  ? 183.982 127.279 175.440 1.00 75.20  ?  509  GLN   C N     1 
ATOM   2794 C CA    . GLN   A 1 509  ? 183.658 128.608 174.931 1.00 76.24  ?  509  GLN   C CA    1 
ATOM   2795 C C     . GLN   A 1 509  ? 183.116 129.544 175.997 1.00 85.01  ?  509  GLN   C C     1 
ATOM   2796 O O     . GLN   A 1 509  ? 182.527 129.117 176.989 1.00 85.65  ?  509  GLN   C O     1 
ATOM   2797 C CB    . GLN   A 1 509  ? 182.657 128.502 173.777 1.00 77.95  ?  509  GLN   C CB    1 
ATOM   2798 C CG    . GLN   A 1 509  ? 181.335 127.862 174.156 1.00 77.27  ?  509  GLN   C CG    1 
ATOM   2799 C CD    . GLN   A 1 509  ? 180.385 127.789 172.996 1.00 77.03  ?  509  GLN   C CD    1 
ATOM   2800 O OE1   . GLN   A 1 509  ? 180.338 128.704 172.177 1.00 76.87  ?  509  GLN   C OE1   1 
ATOM   2801 N NE2   . GLN   A 1 509  ? 179.622 126.706 172.911 1.00 71.69  ?  509  GLN   C NE2   1 
ATOM   2802 N N     . LYS   A 1 510  ? 183.308 130.838 175.767 1.00 91.74  ?  510  LYS   C N     1 
ATOM   2803 C CA    . LYS   A 1 510  ? 182.826 131.871 176.675 1.00 90.81  ?  510  LYS   C CA    1 
ATOM   2804 C C     . LYS   A 1 510  ? 181.478 132.442 176.242 1.00 87.50  ?  510  LYS   C C     1 
ATOM   2805 O O     . LYS   A 1 510  ? 180.911 133.288 176.928 1.00 90.54  ?  510  LYS   C O     1 
ATOM   2806 C CB    . LYS   A 1 510  ? 183.878 132.975 176.804 1.00 96.13  ?  510  LYS   C CB    1 
ATOM   2807 C CG    . LYS   A 1 510  ? 183.518 134.101 177.761 1.00 97.56  ?  510  LYS   C CG    1 
ATOM   2808 C CD    . LYS   A 1 510  ? 184.710 135.008 178.014 1.00 103.59 ?  510  LYS   C CD    1 
ATOM   2809 C CE    . LYS   A 1 510  ? 184.344 136.158 178.939 1.00 100.35 ?  510  LYS   C CE    1 
ATOM   2810 N NZ    . LYS   A 1 510  ? 185.515 137.035 179.217 1.00 108.36 1  510  LYS   C NZ    1 
ATOM   2811 N N     . GLU   A 1 511  ? 180.991 132.020 175.076 1.00 90.44  ?  511  GLU   C N     1 
ATOM   2812 C CA    . GLU   A 1 511  ? 179.734 132.544 174.543 1.00 94.18  ?  511  GLU   C CA    1 
ATOM   2813 C C     . GLU   A 1 511  ? 179.693 134.060 174.666 1.00 98.92  ?  511  GLU   C C     1 
ATOM   2814 O O     . GLU   A 1 511  ? 178.792 134.614 175.291 1.00 102.15 ?  511  GLU   C O     1 
ATOM   2815 C CB    . GLU   A 1 511  ? 178.513 131.944 175.256 1.00 87.21  ?  511  GLU   C CB    1 
ATOM   2816 C CG    . GLU   A 1 511  ? 178.355 130.432 175.122 1.00 91.86  ?  511  GLU   C CG    1 
ATOM   2817 C CD    . GLU   A 1 511  ? 176.958 129.952 175.490 1.00 88.10  ?  511  GLU   C CD    1 
ATOM   2818 O OE1   . GLU   A 1 511  ? 176.128 130.778 175.781 1.00 87.72  ?  511  GLU   C OE1   1 
ATOM   2819 O OE2   . GLU   A 1 511  ? 176.727 128.761 175.481 1.00 79.78  -1 511  GLU   C OE2   1 
ATOM   2820 N N     . VAL   A 1 512  ? 180.674 134.732 174.066 1.00 103.36 ?  512  VAL   C N     1 
ATOM   2821 C CA    . VAL   A 1 512  ? 180.885 136.173 174.241 1.00 108.07 ?  512  VAL   C CA    1 
ATOM   2822 C C     . VAL   A 1 512  ? 179.841 137.078 173.587 1.00 107.71 ?  512  VAL   C C     1 
ATOM   2823 O O     . VAL   A 1 512  ? 180.167 138.174 173.127 1.00 106.34 ?  512  VAL   C O     1 
ATOM   2824 C CB    . VAL   A 1 512  ? 182.263 136.574 173.678 1.00 109.33 ?  512  VAL   C CB    1 
ATOM   2825 C CG1   . VAL   A 1 512  ? 183.349 135.855 174.427 1.00 107.17 ?  512  VAL   C CG1   1 
ATOM   2826 C CG2   . VAL   A 1 512  ? 182.327 136.243 172.176 1.00 109.13 ?  512  VAL   C CG2   1 
ATOM   2827 N N     . ASP   A 1 513  ? 178.587 136.651 173.570 1.00 109.07 ?  513  ASP   C N     1 
ATOM   2828 C CA    . ASP   A 1 513  ? 177.523 137.458 172.998 1.00 114.25 ?  513  ASP   C CA    1 
ATOM   2829 C C     . ASP   A 1 513  ? 176.992 138.414 174.057 1.00 127.98 ?  513  ASP   C C     1 
ATOM   2830 O O     . ASP   A 1 513  ? 175.848 138.304 174.497 1.00 110.67 ?  513  ASP   C O     1 
ATOM   2831 C CB    . ASP   A 1 513  ? 176.400 136.562 172.470 1.00 104.03 ?  513  ASP   C CB    1 
ATOM   2832 C CG    . ASP   A 1 513  ? 175.403 137.303 171.585 1.00 92.59  ?  513  ASP   C CG    1 
ATOM   2833 O OD1   . ASP   A 1 513  ? 175.740 138.363 171.113 1.00 104.99 ?  513  ASP   C OD1   1 
ATOM   2834 O OD2   . ASP   A 1 513  ? 174.315 136.803 171.389 1.00 86.03  -1 513  ASP   C OD2   1 
ATOM   2835 N N     . CYS   A 1 514  ? 177.851 139.340 174.481 1.00 114.63 ?  514  CYS   C N     1 
ATOM   2836 C CA    . CYS   A 1 514  ? 177.525 140.284 175.547 1.00 125.54 ?  514  CYS   C CA    1 
ATOM   2837 C C     . CYS   A 1 514  ? 176.989 139.546 176.770 1.00 110.74 ?  514  CYS   C C     1 
ATOM   2838 O O     . CYS   A 1 514  ? 175.937 139.895 177.305 1.00 112.13 ?  514  CYS   C O     1 
ATOM   2839 C CB    . CYS   A 1 514  ? 176.493 141.303 175.070 1.00 150.09 ?  514  CYS   C CB    1 
ATOM   2840 S SG    . CYS   A 1 514  ? 177.033 142.263 173.642 1.00 182.21 ?  514  CYS   C SG    1 
ATOM   2841 N N     . GLU   A 1 515  ? 177.714 138.515 177.190 1.00 113.43 ?  515  GLU   C N     1 
ATOM   2842 C CA    . GLU   A 1 515  ? 177.290 137.654 178.285 1.00 108.58 ?  515  GLU   C CA    1 
ATOM   2843 C C     . GLU   A 1 515  ? 178.501 137.134 179.059 1.00 114.31 ?  515  GLU   C C     1 
ATOM   2844 O O     . GLU   A 1 515  ? 179.618 137.128 178.541 1.00 112.16 ?  515  GLU   C O     1 
ATOM   2845 C CB    . GLU   A 1 515  ? 176.442 136.504 177.724 1.00 113.74 ?  515  GLU   C CB    1 
ATOM   2846 C CG    . GLU   A 1 515  ? 175.815 135.575 178.751 1.00 116.30 ?  515  GLU   C CG    1 
ATOM   2847 C CD    . GLU   A 1 515  ? 174.965 136.287 179.771 1.00 119.36 ?  515  GLU   C CD    1 
ATOM   2848 O OE1   . GLU   A 1 515  ? 173.767 136.267 179.643 1.00 109.63 ?  515  GLU   C OE1   1 
ATOM   2849 O OE2   . GLU   A 1 515  ? 175.529 136.843 180.687 1.00 117.96 -1 515  GLU   C OE2   1 
ATOM   2850 N N     . LYS   A 1 516  ? 178.280 136.732 180.312 1.00 113.26 ?  516  LYS   C N     1 
ATOM   2851 C CA    . LYS   A 1 516  ? 179.361 136.258 181.181 1.00 110.68 ?  516  LYS   C CA    1 
ATOM   2852 C C     . LYS   A 1 516  ? 179.244 134.783 181.567 1.00 104.47 ?  516  LYS   C C     1 
ATOM   2853 O O     . LYS   A 1 516  ? 179.745 134.376 182.616 1.00 101.17 ?  516  LYS   C O     1 
ATOM   2854 C CB    . LYS   A 1 516  ? 179.427 137.106 182.448 1.00 106.39 ?  516  LYS   C CB    1 
ATOM   2855 C CG    . LYS   A 1 516  ? 179.786 138.562 182.205 1.00 120.95 ?  516  LYS   C CG    1 
ATOM   2856 C CD    . LYS   A 1 516  ? 179.893 139.330 183.512 1.00 123.35 ?  516  LYS   C CD    1 
ATOM   2857 C CE    . LYS   A 1 516  ? 180.282 140.784 183.271 1.00 130.37 ?  516  LYS   C CE    1 
ATOM   2858 N NZ    . LYS   A 1 516  ? 180.369 141.554 184.543 1.00 133.09 1  516  LYS   C NZ    1 
ATOM   2859 N N     . PHE   A 1 517  ? 178.582 133.986 180.740 1.00 103.93 ?  517  PHE   C N     1 
ATOM   2860 C CA    . PHE   A 1 517  ? 178.463 132.554 181.004 1.00 96.59  ?  517  PHE   C CA    1 
ATOM   2861 C C     . PHE   A 1 517  ? 179.430 131.750 180.161 1.00 91.51  ?  517  PHE   C C     1 
ATOM   2862 O O     . PHE   A 1 517  ? 179.748 132.125 179.038 1.00 89.28  ?  517  PHE   C O     1 
ATOM   2863 C CB    . PHE   A 1 517  ? 177.055 132.036 180.734 1.00 95.56  ?  517  PHE   C CB    1 
ATOM   2864 C CG    . PHE   A 1 517  ? 176.057 132.394 181.772 1.00 93.74  ?  517  PHE   C CG    1 
ATOM   2865 C CD1   . PHE   A 1 517  ? 176.088 131.783 183.014 1.00 93.08  ?  517  PHE   C CD1   1 
ATOM   2866 C CD2   . PHE   A 1 517  ? 175.077 133.322 181.517 1.00 93.63  ?  517  PHE   C CD2   1 
ATOM   2867 C CE1   . PHE   A 1 517  ? 175.161 132.106 183.977 1.00 99.59  ?  517  PHE   C CE1   1 
ATOM   2868 C CE2   . PHE   A 1 517  ? 174.147 133.651 182.471 1.00 101.90 ?  517  PHE   C CE2   1 
ATOM   2869 C CZ    . PHE   A 1 517  ? 174.190 133.044 183.708 1.00 102.00 ?  517  PHE   C CZ    1 
ATOM   2870 N N     . TYR   A 1 518  ? 179.868 130.626 180.698 1.00 86.36  ?  518  TYR   C N     1 
ATOM   2871 C CA    . TYR   A 1 518  ? 180.748 129.720 179.980 1.00 84.74  ?  518  TYR   C CA    1 
ATOM   2872 C C     . TYR   A 1 518  ? 180.038 128.417 179.673 1.00 83.09  ?  518  TYR   C C     1 
ATOM   2873 O O     . TYR   A 1 518  ? 179.107 128.027 180.379 1.00 80.98  ?  518  TYR   C O     1 
ATOM   2874 C CB    . TYR   A 1 518  ? 182.002 129.449 180.790 1.00 86.18  ?  518  TYR   C CB    1 
ATOM   2875 C CG    . TYR   A 1 518  ? 182.874 130.645 180.974 1.00 86.98  ?  518  TYR   C CG    1 
ATOM   2876 C CD1   . TYR   A 1 518  ? 182.586 131.551 181.965 1.00 96.86  ?  518  TYR   C CD1   1 
ATOM   2877 C CD2   . TYR   A 1 518  ? 183.971 130.837 180.149 1.00 88.20  ?  518  TYR   C CD2   1 
ATOM   2878 C CE1   . TYR   A 1 518  ? 183.383 132.646 182.143 1.00 102.53 ?  518  TYR   C CE1   1 
ATOM   2879 C CE2   . TYR   A 1 518  ? 184.774 131.938 180.328 1.00 93.11  ?  518  TYR   C CE2   1 
ATOM   2880 C CZ    . TYR   A 1 518  ? 184.481 132.843 181.330 1.00 105.70 ?  518  TYR   C CZ    1 
ATOM   2881 O OH    . TYR   A 1 518  ? 185.279 133.952 181.527 1.00 104.33 ?  518  TYR   C OH    1 
ATOM   2882 N N     . SER   A 1 519  ? 180.477 127.739 178.624 1.00 78.27  ?  519  SER   C N     1 
ATOM   2883 C CA    . SER   A 1 519  ? 179.879 126.464 178.257 1.00 71.30  ?  519  SER   C CA    1 
ATOM   2884 C C     . SER   A 1 519  ? 180.813 125.619 177.406 1.00 70.69  ?  519  SER   C C     1 
ATOM   2885 O O     . SER   A 1 519  ? 181.838 126.094 176.917 1.00 73.44  ?  519  SER   C O     1 
ATOM   2886 C CB    . SER   A 1 519  ? 178.589 126.704 177.504 1.00 67.07  ?  519  SER   C CB    1 
ATOM   2887 O OG    . SER   A 1 519  ? 178.848 127.254 176.247 1.00 74.62  ?  519  SER   C OG    1 
ATOM   2888 N N     . PHE   A 1 520  ? 180.439 124.365 177.215 1.00 63.84  ?  520  PHE   C N     1 
ATOM   2889 C CA    . PHE   A 1 520  ? 181.178 123.467 176.346 1.00 61.28  ?  520  PHE   C CA    1 
ATOM   2890 C C     . PHE   A 1 520  ? 180.824 123.755 174.896 1.00 59.47  ?  520  PHE   C C     1 
ATOM   2891 O O     . PHE   A 1 520  ? 179.780 124.343 174.616 1.00 59.79  ?  520  PHE   C O     1 
ATOM   2892 C CB    . PHE   A 1 520  ? 180.871 122.012 176.699 1.00 59.11  ?  520  PHE   C CB    1 
ATOM   2893 C CG    . PHE   A 1 520  ? 181.487 121.568 178.002 1.00 58.44  ?  520  PHE   C CG    1 
ATOM   2894 C CD1   . PHE   A 1 520  ? 180.793 121.685 179.197 1.00 62.47  ?  520  PHE   C CD1   1 
ATOM   2895 C CD2   . PHE   A 1 520  ? 182.762 121.030 178.031 1.00 60.01  ?  520  PHE   C CD2   1 
ATOM   2896 C CE1   . PHE   A 1 520  ? 181.366 121.278 180.386 1.00 69.14  ?  520  PHE   C CE1   1 
ATOM   2897 C CE2   . PHE   A 1 520  ? 183.331 120.623 179.217 1.00 61.23  ?  520  PHE   C CE2   1 
ATOM   2898 C CZ    . PHE   A 1 520  ? 182.634 120.749 180.394 1.00 67.55  ?  520  PHE   C CZ    1 
ATOM   2899 N N     . ILE   A 1 521  ? 181.683 123.334 173.973 1.00 56.80  ?  521  ILE   C N     1 
ATOM   2900 C CA    . ILE   A 1 521  ? 181.438 123.547 172.549 1.00 52.44  ?  521  ILE   C CA    1 
ATOM   2901 C C     . ILE   A 1 521  ? 180.105 122.958 172.126 1.00 51.59  ?  521  ILE   C C     1 
ATOM   2902 O O     . ILE   A 1 521  ? 179.385 123.539 171.316 1.00 53.57  ?  521  ILE   C O     1 
ATOM   2903 C CB    . ILE   A 1 521  ? 182.551 122.918 171.696 1.00 52.77  ?  521  ILE   C CB    1 
ATOM   2904 C CG1   . ILE   A 1 521  ? 183.837 123.693 171.890 1.00 59.96  ?  521  ILE   C CG1   1 
ATOM   2905 C CG2   . ILE   A 1 521  ? 182.142 122.887 170.213 1.00 56.46  ?  521  ILE   C CG2   1 
ATOM   2906 C CD1   . ILE   A 1 521  ? 185.046 122.985 171.351 1.00 63.63  ?  521  ILE   C CD1   1 
ATOM   2907 N N     . HIS   A 1 522  ? 179.800 121.784 172.649 1.00 49.37  ?  522  HIS   C N     1 
ATOM   2908 C CA    . HIS   A 1 522  ? 178.570 121.091 172.319 1.00 46.88  ?  522  HIS   C CA    1 
ATOM   2909 C C     . HIS   A 1 522  ? 178.192 120.172 173.463 1.00 50.44  ?  522  HIS   C C     1 
ATOM   2910 O O     . HIS   A 1 522  ? 179.063 119.683 174.184 1.00 50.85  ?  522  HIS   C O     1 
ATOM   2911 C CB    . HIS   A 1 522  ? 178.722 120.291 171.026 1.00 45.45  ?  522  HIS   C CB    1 
ATOM   2912 C CG    . HIS   A 1 522  ? 177.427 119.861 170.442 1.00 43.82  ?  522  HIS   C CG    1 
ATOM   2913 N ND1   . HIS   A 1 522  ? 176.770 118.705 170.830 1.00 45.40  ?  522  HIS   C ND1   1 
ATOM   2914 C CD2   . HIS   A 1 522  ? 176.650 120.439 169.500 1.00 42.24  ?  522  HIS   C CD2   1 
ATOM   2915 C CE1   . HIS   A 1 522  ? 175.645 118.599 170.143 1.00 45.60  ?  522  HIS   C CE1   1 
ATOM   2916 N NE2   . HIS   A 1 522  ? 175.553 119.638 169.332 1.00 47.36  ?  522  HIS   C NE2   1 
ATOM   2917 N N     . MET   A 1 523  ? 176.902 119.900 173.614 1.00 48.27  ?  523  MET   C N     1 
ATOM   2918 C CA    . MET   A 1 523  ? 176.458 119.006 174.674 1.00 49.11  ?  523  MET   C CA    1 
ATOM   2919 C C     . MET   A 1 523  ? 177.129 117.650 174.576 1.00 49.00  ?  523  MET   C C     1 
ATOM   2920 O O     . MET   A 1 523  ? 177.320 116.974 175.587 1.00 51.93  ?  523  MET   C O     1 
ATOM   2921 C CB    . MET   A 1 523  ? 174.945 118.833 174.633 1.00 48.62  ?  523  MET   C CB    1 
ATOM   2922 C CG    . MET   A 1 523  ? 174.165 120.048 175.075 1.00 58.31  ?  523  MET   C CG    1 
ATOM   2923 S SD    . MET   A 1 523  ? 174.669 120.635 176.709 1.00 81.67  ?  523  MET   C SD    1 
ATOM   2924 C CE    . MET   A 1 523  ? 174.270 119.250 177.782 1.00 68.16  ?  523  MET   C CE    1 
ATOM   2925 N N     . THR   A 1 524  ? 177.503 117.256 173.368 1.00 45.11  ?  524  THR   C N     1 
ATOM   2926 C CA    . THR   A 1 524  ? 178.161 115.981 173.172 1.00 43.14  ?  524  THR   C CA    1 
ATOM   2927 C C     . THR   A 1 524  ? 179.499 115.966 173.908 1.00 44.79  ?  524  THR   C C     1 
ATOM   2928 O O     . THR   A 1 524  ? 179.898 114.944 174.464 1.00 48.43  ?  524  THR   C O     1 
ATOM   2929 C CB    . THR   A 1 524  ? 178.372 115.692 171.682 1.00 41.58  ?  524  THR   C CB    1 
ATOM   2930 O OG1   . THR   A 1 524  ? 177.117 115.790 171.006 1.00 42.84  ?  524  THR   C OG1   1 
ATOM   2931 C CG2   . THR   A 1 524  ? 178.910 114.286 171.512 1.00 46.08  ?  524  THR   C CG2   1 
ATOM   2932 N N     . PHE   A 1 525  ? 180.197 117.104 173.903 1.00 44.45  ?  525  PHE   C N     1 
ATOM   2933 C CA    . PHE   A 1 525  ? 181.477 117.204 174.589 1.00 46.39  ?  525  PHE   C CA    1 
ATOM   2934 C C     . PHE   A 1 525  ? 181.266 117.179 176.087 1.00 52.61  ?  525  PHE   C C     1 
ATOM   2935 O O     . PHE   A 1 525  ? 182.025 116.539 176.818 1.00 54.08  ?  525  PHE   C O     1 
ATOM   2936 C CB    . PHE   A 1 525  ? 182.215 118.491 174.215 1.00 45.55  ?  525  PHE   C CB    1 
ATOM   2937 C CG    . PHE   A 1 525  ? 183.026 118.419 172.959 1.00 40.51  ?  525  PHE   C CG    1 
ATOM   2938 C CD1   . PHE   A 1 525  ? 182.552 118.942 171.766 1.00 44.55  ?  525  PHE   C CD1   1 
ATOM   2939 C CD2   . PHE   A 1 525  ? 184.283 117.840 172.979 1.00 40.19  ?  525  PHE   C CD2   1 
ATOM   2940 C CE1   . PHE   A 1 525  ? 183.319 118.882 170.620 1.00 43.87  ?  525  PHE   C CE1   1 
ATOM   2941 C CE2   . PHE   A 1 525  ? 185.048 117.779 171.840 1.00 42.41  ?  525  PHE   C CE2   1 
ATOM   2942 C CZ    . PHE   A 1 525  ? 184.569 118.302 170.659 1.00 46.02  ?  525  PHE   C CZ    1 
ATOM   2943 N N     . GLN   A 1 526  ? 180.231 117.869 176.552 1.00 53.78  ?  526  GLN   C N     1 
ATOM   2944 C CA    . GLN   A 1 526  ? 179.966 117.898 177.980 1.00 57.39  ?  526  GLN   C CA    1 
ATOM   2945 C C     . GLN   A 1 526  ? 179.676 116.496 178.491 1.00 56.52  ?  526  GLN   C C     1 
ATOM   2946 O O     . GLN   A 1 526  ? 180.190 116.088 179.531 1.00 60.46  ?  526  GLN   C O     1 
ATOM   2947 C CB    . GLN   A 1 526  ? 178.798 118.823 178.315 1.00 56.41  ?  526  GLN   C CB    1 
ATOM   2948 C CG    . GLN   A 1 526  ? 178.538 118.946 179.807 1.00 56.55  ?  526  GLN   C CG    1 
ATOM   2949 C CD    . GLN   A 1 526  ? 177.527 120.013 180.146 1.00 65.12  ?  526  GLN   C CD    1 
ATOM   2950 O OE1   . GLN   A 1 526  ? 177.027 120.720 179.270 1.00 59.94  ?  526  GLN   C OE1   1 
ATOM   2951 N NE2   . GLN   A 1 526  ? 177.224 120.135 181.431 1.00 71.07  ?  526  GLN   C NE2   1 
ATOM   2952 N N     . GLU   A 1 527  ? 178.876 115.745 177.738 1.00 51.89  ?  527  GLU   C N     1 
ATOM   2953 C CA    . GLU   A 1 527  ? 178.568 114.383 178.135 1.00 52.12  ?  527  GLU   C CA    1 
ATOM   2954 C C     . GLU   A 1 527  ? 179.814 113.505 178.080 1.00 53.94  ?  527  GLU   C C     1 
ATOM   2955 O O     . GLU   A 1 527  ? 180.006 112.645 178.941 1.00 55.62  ?  527  GLU   C O     1 
ATOM   2956 C CB    . GLU   A 1 527  ? 177.451 113.799 177.268 1.00 48.75  ?  527  GLU   C CB    1 
ATOM   2957 C CG    . GLU   A 1 527  ? 176.056 114.396 177.538 1.00 50.01  ?  527  GLU   C CG    1 
ATOM   2958 C CD    . GLU   A 1 527  ? 174.926 113.624 176.870 1.00 50.24  ?  527  GLU   C CD    1 
ATOM   2959 O OE1   . GLU   A 1 527  ? 174.855 112.419 177.042 1.00 48.44  ?  527  GLU   C OE1   1 
ATOM   2960 O OE2   . GLU   A 1 527  ? 174.140 114.227 176.186 1.00 45.40  -1 527  GLU   C OE2   1 
ATOM   2961 N N     . PHE   A 1 528  ? 180.679 113.742 177.094 1.00 52.09  ?  528  PHE   C N     1 
ATOM   2962 C CA    . PHE   A 1 528  ? 181.926 112.993 176.995 1.00 53.21  ?  528  PHE   C CA    1 
ATOM   2963 C C     . PHE   A 1 528  ? 182.742 113.144 178.266 1.00 56.54  ?  528  PHE   C C     1 
ATOM   2964 O O     . PHE   A 1 528  ? 183.201 112.160 178.845 1.00 58.72  ?  528  PHE   C O     1 
ATOM   2965 C CB    . PHE   A 1 528  ? 182.771 113.471 175.814 1.00 50.34  ?  528  PHE   C CB    1 
ATOM   2966 C CG    . PHE   A 1 528  ? 184.082 112.763 175.712 1.00 48.25  ?  528  PHE   C CG    1 
ATOM   2967 C CD1   . PHE   A 1 528  ? 184.213 111.653 174.917 1.00 46.78  ?  528  PHE   C CD1   1 
ATOM   2968 C CD2   . PHE   A 1 528  ? 185.184 113.193 176.428 1.00 56.39  ?  528  PHE   C CD2   1 
ATOM   2969 C CE1   . PHE   A 1 528  ? 185.403 110.982 174.828 1.00 52.32  ?  528  PHE   C CE1   1 
ATOM   2970 C CE2   . PHE   A 1 528  ? 186.371 112.523 176.345 1.00 55.30  ?  528  PHE   C CE2   1 
ATOM   2971 C CZ    . PHE   A 1 528  ? 186.481 111.416 175.543 1.00 50.41  ?  528  PHE   C CZ    1 
ATOM   2972 N N     . PHE   A 1 529  ? 182.929 114.385 178.701 1.00 57.14  ?  529  PHE   C N     1 
ATOM   2973 C CA    . PHE   A 1 529  ? 183.738 114.625 179.886 1.00 61.50  ?  529  PHE   C CA    1 
ATOM   2974 C C     . PHE   A 1 529  ? 183.074 114.031 181.117 1.00 65.32  ?  529  PHE   C C     1 
ATOM   2975 O O     . PHE   A 1 529  ? 183.755 113.465 181.983 1.00 70.17  ?  529  PHE   C O     1 
ATOM   2976 C CB    . PHE   A 1 529  ? 183.985 116.121 180.070 1.00 64.86  ?  529  PHE   C CB    1 
ATOM   2977 C CG    . PHE   A 1 529  ? 185.043 116.673 179.152 1.00 66.81  ?  529  PHE   C CG    1 
ATOM   2978 C CD1   . PHE   A 1 529  ? 184.704 117.516 178.107 1.00 61.42  ?  529  PHE   C CD1   1 
ATOM   2979 C CD2   . PHE   A 1 529  ? 186.379 116.347 179.331 1.00 67.00  ?  529  PHE   C CD2   1 
ATOM   2980 C CE1   . PHE   A 1 529  ? 185.670 118.020 177.268 1.00 62.40  ?  529  PHE   C CE1   1 
ATOM   2981 C CE2   . PHE   A 1 529  ? 187.342 116.854 178.490 1.00 65.58  ?  529  PHE   C CE2   1 
ATOM   2982 C CZ    . PHE   A 1 529  ? 186.985 117.688 177.463 1.00 65.79  ?  529  PHE   C CZ    1 
ATOM   2983 N N     . ALA   A 1 530  ? 181.752 114.128 181.207 1.00 61.52  ?  530  ALA   C N     1 
ATOM   2984 C CA    . ALA   A 1 530  ? 181.036 113.561 182.331 1.00 66.23  ?  530  ALA   C CA    1 
ATOM   2985 C C     . ALA   A 1 530  ? 181.257 112.052 182.408 1.00 64.11  ?  530  ALA   C C     1 
ATOM   2986 O O     . ALA   A 1 530  ? 181.366 111.487 183.479 1.00 68.50  ?  530  ALA   C O     1 
ATOM   2987 C CB    . ALA   A 1 530  ? 179.554 113.866 182.249 1.00 65.22  ?  530  ALA   C CB    1 
ATOM   2988 N N     . ALA   A 1 531  ? 181.307 111.417 181.228 1.00 57.08  ?  531  ALA   C N     1 
ATOM   2989 C CA    . ALA   A 1 531  ? 181.536 109.970 181.160 1.00 59.70  ?  531  ALA   C CA    1 
ATOM   2990 C C     . ALA   A 1 531  ? 182.950 109.636 181.583 1.00 62.69  ?  531  ALA   C C     1 
ATOM   2991 O O     . ALA   A 1 531  ? 183.185 108.633 182.268 1.00 67.69  ?  531  ALA   C O     1 
ATOM   2992 C CB    . ALA   A 1 531  ? 181.316 109.486 179.736 1.00 62.48  ?  531  ALA   C CB    1 
ATOM   2993 N N     . MET   A 1 532  ? 183.893 110.483 181.210 1.00 61.32  ?  532  MET   C N     1 
ATOM   2994 C CA    . MET   A 1 532  ? 185.292 110.274 181.534 1.00 66.81  ?  532  MET   C CA    1 
ATOM   2995 C C     . MET   A 1 532  ? 185.476 110.244 183.039 1.00 72.10  ?  532  MET   C C     1 
ATOM   2996 O O     . MET   A 1 532  ? 186.276 109.475 183.564 1.00 74.53  ?  532  MET   C O     1 
ATOM   2997 C CB    . MET   A 1 532  ? 186.149 111.374 180.915 1.00 68.31  ?  532  MET   C CB    1 
ATOM   2998 C CG    . MET   A 1 532  ? 187.648 111.171 181.057 1.00 72.78  ?  532  MET   C CG    1 
ATOM   2999 S SD    . MET   A 1 532  ? 188.239 109.723 180.195 1.00 91.42  ?  532  MET   C SD    1 
ATOM   3000 C CE    . MET   A 1 532  ? 188.327 110.335 178.525 1.00 74.72  ?  532  MET   C CE    1 
ATOM   3001 N N     . TYR   A 1 533  ? 184.686 111.058 183.727 1.00 72.25  ?  533  TYR   C N     1 
ATOM   3002 C CA    . TYR   A 1 533  ? 184.735 111.201 185.176 1.00 78.18  ?  533  TYR   C CA    1 
ATOM   3003 C C     . TYR   A 1 533  ? 184.522 109.881 185.911 1.00 77.27  ?  533  TYR   C C     1 
ATOM   3004 O O     . TYR   A 1 533  ? 184.943 109.729 187.057 1.00 80.58  ?  533  TYR   C O     1 
ATOM   3005 C CB    . TYR   A 1 533  ? 183.676 112.215 185.617 1.00 79.92  ?  533  TYR   C CB    1 
ATOM   3006 C CG    . TYR   A 1 533  ? 183.788 112.672 187.044 1.00 82.81  ?  533  TYR   C CG    1 
ATOM   3007 C CD1   . TYR   A 1 533  ? 184.921 113.341 187.458 1.00 90.01  ?  533  TYR   C CD1   1 
ATOM   3008 C CD2   . TYR   A 1 533  ? 182.746 112.452 187.930 1.00 82.65  ?  533  TYR   C CD2   1 
ATOM   3009 C CE1   . TYR   A 1 533  ? 185.024 113.785 188.747 1.00 93.43  ?  533  TYR   C CE1   1 
ATOM   3010 C CE2   . TYR   A 1 533  ? 182.847 112.904 189.225 1.00 87.68  ?  533  TYR   C CE2   1 
ATOM   3011 C CZ    . TYR   A 1 533  ? 183.982 113.570 189.633 1.00 92.80  ?  533  TYR   C CZ    1 
ATOM   3012 O OH    . TYR   A 1 533  ? 184.084 114.030 190.920 1.00 97.79  ?  533  TYR   C OH    1 
ATOM   3013 N N     . TYR   A 1 534  ? 183.853 108.932 185.268 1.00 71.06  ?  534  TYR   C N     1 
ATOM   3014 C CA    . TYR   A 1 534  ? 183.527 107.673 185.921 1.00 72.91  ?  534  TYR   C CA    1 
ATOM   3015 C C     . TYR   A 1 534  ? 184.648 106.648 185.826 1.00 77.39  ?  534  TYR   C C     1 
ATOM   3016 O O     . TYR   A 1 534  ? 184.563 105.584 186.439 1.00 79.94  ?  534  TYR   C O     1 
ATOM   3017 C CB    . TYR   A 1 534  ? 182.244 107.097 185.327 1.00 71.79  ?  534  TYR   C CB    1 
ATOM   3018 C CG    . TYR   A 1 534  ? 181.015 107.874 185.707 1.00 68.42  ?  534  TYR   C CG    1 
ATOM   3019 C CD1   . TYR   A 1 534  ? 180.631 108.955 184.942 1.00 68.62  ?  534  TYR   C CD1   1 
ATOM   3020 C CD2   . TYR   A 1 534  ? 180.273 107.511 186.821 1.00 72.57  ?  534  TYR   C CD2   1 
ATOM   3021 C CE1   . TYR   A 1 534  ? 179.516 109.683 185.284 1.00 67.38  ?  534  TYR   C CE1   1 
ATOM   3022 C CE2   . TYR   A 1 534  ? 179.153 108.236 187.162 1.00 72.55  ?  534  TYR   C CE2   1 
ATOM   3023 C CZ    . TYR   A 1 534  ? 178.778 109.322 186.400 1.00 70.46  ?  534  TYR   C CZ    1 
ATOM   3024 O OH    . TYR   A 1 534  ? 177.667 110.050 186.748 1.00 72.78  ?  534  TYR   C OH    1 
ATOM   3025 N N     . LEU   A 1 535  ? 185.684 106.946 185.046 1.00 79.00  ?  535  LEU   C N     1 
ATOM   3026 C CA    . LEU   A 1 535  ? 186.797 106.017 184.871 1.00 84.72  ?  535  LEU   C CA    1 
ATOM   3027 C C     . LEU   A 1 535  ? 188.102 106.516 185.486 1.00 89.69  ?  535  LEU   C C     1 
ATOM   3028 O O     . LEU   A 1 535  ? 189.169 105.946 185.248 1.00 94.24  ?  535  LEU   C O     1 
ATOM   3029 C CB    . LEU   A 1 535  ? 187.002 105.739 183.377 1.00 87.00  ?  535  LEU   C CB    1 
ATOM   3030 C CG    . LEU   A 1 535  ? 185.826 105.046 182.656 1.00 82.58  ?  535  LEU   C CG    1 
ATOM   3031 C CD1   . LEU   A 1 535  ? 186.089 105.010 181.160 1.00 78.81  ?  535  LEU   C CD1   1 
ATOM   3032 C CD2   . LEU   A 1 535  ? 185.667 103.632 183.191 1.00 83.81  ?  535  LEU   C CD2   1 
ATOM   3033 N N     . LEU   A 1 536  ? 188.025 107.587 186.262 1.00 86.45  ?  536  LEU   C N     1 
ATOM   3034 C CA    . LEU   A 1 536  ? 189.229 108.183 186.827 1.00 89.71  ?  536  LEU   C CA    1 
ATOM   3035 C C     . LEU   A 1 536  ? 189.461 107.759 188.274 1.00 93.77  ?  536  LEU   C C     1 
ATOM   3036 O O     . LEU   A 1 536  ? 188.512 107.482 189.011 1.00 96.41  ?  536  LEU   C O     1 
ATOM   3037 C CB    . LEU   A 1 536  ? 189.139 109.715 186.753 1.00 87.18  ?  536  LEU   C CB    1 
ATOM   3038 C CG    . LEU   A 1 536  ? 188.893 110.305 185.359 1.00 83.82  ?  536  LEU   C CG    1 
ATOM   3039 C CD1   . LEU   A 1 536  ? 188.753 111.815 185.466 1.00 91.40  ?  536  LEU   C CD1   1 
ATOM   3040 C CD2   . LEU   A 1 536  ? 190.037 109.924 184.422 1.00 92.28  ?  536  LEU   C CD2   1 
ATOM   3041 N N     . GLU   A 1 537  ? 190.741 107.736 188.678 1.00 96.79  ?  537  GLU   C N     1 
ATOM   3042 C CA    . GLU   A 1 537  ? 191.199 107.451 190.044 1.00 102.61 ?  537  GLU   C CA    1 
ATOM   3043 C C     . GLU   A 1 537  ? 190.448 106.295 190.707 1.00 105.11 ?  537  GLU   C C     1 
ATOM   3044 O O     . GLU   A 1 537  ? 190.881 105.139 190.646 1.00 108.46 ?  537  GLU   C O     1 
ATOM   3045 C CB    . GLU   A 1 537  ? 191.103 108.719 190.926 1.00 104.78 ?  537  GLU   C CB    1 
ATOM   3046 C CG    . GLU   A 1 537  ? 192.094 109.871 190.552 1.00 111.16 ?  537  GLU   C CG    1 
ATOM   3047 C CD    . GLU   A 1 537  ? 193.568 109.523 190.789 1.00 122.06 ?  537  GLU   C CD    1 
ATOM   3048 O OE1   . GLU   A 1 537  ? 193.884 109.031 191.846 1.00 111.36 ?  537  GLU   C OE1   1 
ATOM   3049 O OE2   . GLU   A 1 537  ? 194.360 109.750 189.904 1.00 113.73 -1 537  GLU   C OE2   1 
ATOM   3050 N N     . LEU   A 1 553  ? 181.386 116.294 192.939 1.00 91.86  ?  553  LEU   C N     1 
ATOM   3051 C CA    . LEU   A 1 553  ? 181.463 114.865 193.221 1.00 96.82  ?  553  LEU   C CA    1 
ATOM   3052 C C     . LEU   A 1 553  ? 180.036 114.275 193.365 1.00 94.90  ?  553  LEU   C C     1 
ATOM   3053 O O     . LEU   A 1 553  ? 179.686 113.768 194.434 1.00 96.97  ?  553  LEU   C O     1 
ATOM   3054 C CB    . LEU   A 1 553  ? 182.302 114.643 194.513 1.00 102.53 ?  553  LEU   C CB    1 
ATOM   3055 C CG    . LEU   A 1 553  ? 182.718 113.149 194.894 1.00 105.99 ?  553  LEU   C CG    1 
ATOM   3056 C CD1   . LEU   A 1 553  ? 183.708 112.584 193.845 1.00 100.25 ?  553  LEU   C CD1   1 
ATOM   3057 C CD2   . LEU   A 1 553  ? 183.352 113.144 196.303 1.00 107.07 ?  553  LEU   C CD2   1 
ATOM   3058 N N     . PRO   A 1 554  ? 179.190 114.325 192.295 1.00 91.50  ?  554  PRO   C N     1 
ATOM   3059 C CA    . PRO   A 1 554  ? 177.767 113.997 192.303 1.00 92.97  ?  554  PRO   C CA    1 
ATOM   3060 C C     . PRO   A 1 554  ? 177.438 112.521 192.535 1.00 93.36  ?  554  PRO   C C     1 
ATOM   3061 O O     . PRO   A 1 554  ? 176.329 112.203 192.961 1.00 93.69  ?  554  PRO   C O     1 
ATOM   3062 C CB    . PRO   A 1 554  ? 177.323 114.427 190.896 1.00 87.03  ?  554  PRO   C CB    1 
ATOM   3063 C CG    . PRO   A 1 554  ? 178.566 114.333 190.039 1.00 86.77  ?  554  PRO   C CG    1 
ATOM   3064 C CD    . PRO   A 1 554  ? 179.694 114.724 190.943 1.00 90.72  ?  554  PRO   C CD    1 
ATOM   3065 N N     . SER   A 1 555  ? 178.375 111.619 192.249 1.00 90.56  ?  555  SER   C N     1 
ATOM   3066 C CA    . SER   A 1 555  ? 178.072 110.202 192.429 1.00 89.70  ?  555  SER   C CA    1 
ATOM   3067 C C     . SER   A 1 555  ? 179.301 109.305 192.404 1.00 88.42  ?  555  SER   C C     1 
ATOM   3068 O O     . SER   A 1 555  ? 179.639 108.666 193.399 1.00 87.93  ?  555  SER   C O     1 
ATOM   3069 C CB    . SER   A 1 555  ? 177.129 109.730 191.342 1.00 87.29  ?  555  SER   C CB    1 
ATOM   3070 O OG    . SER   A 1 555  ? 177.792 109.647 190.106 1.00 85.84  ?  555  SER   C OG    1 
ATOM   3071 N N     . ARG   A 1 556  ? 179.930 109.232 191.231 1.00 86.58  ?  556  ARG   C N     1 
ATOM   3072 C CA    . ARG   A 1 556  ? 181.010 108.285 190.937 1.00 86.76  ?  556  ARG   C CA    1 
ATOM   3073 C C     . ARG   A 1 556  ? 180.503 106.855 191.040 1.00 85.09  ?  556  ARG   C C     1 
ATOM   3074 O O     . ARG   A 1 556  ? 181.213 105.960 191.500 1.00 85.17  ?  556  ARG   C O     1 
ATOM   3075 C CB    . ARG   A 1 556  ? 182.190 108.442 191.886 1.00 87.60  ?  556  ARG   C CB    1 
ATOM   3076 C CG    . ARG   A 1 556  ? 182.796 109.809 191.953 1.00 93.07  ?  556  ARG   C CG    1 
ATOM   3077 C CD    . ARG   A 1 556  ? 183.706 110.096 190.807 1.00 90.07  ?  556  ARG   C CD    1 
ATOM   3078 N NE    . ARG   A 1 556  ? 184.833 109.176 190.741 1.00 89.69  ?  556  ARG   C NE    1 
ATOM   3079 C CZ    . ARG   A 1 556  ? 185.952 109.274 191.489 1.00 99.03  ?  556  ARG   C CZ    1 
ATOM   3080 N NH1   . ARG   A 1 556  ? 186.081 110.240 192.374 1.00 99.13  1  556  ARG   C NH1   1 
ATOM   3081 N NH2   . ARG   A 1 556  ? 186.925 108.394 191.332 1.00 97.77  ?  556  ARG   C NH2   1 
ATOM   3082 N N     . ASP   A 1 557  ? 179.272 106.647 190.588 1.00 84.31  ?  557  ASP   C N     1 
ATOM   3083 C CA    . ASP   A 1 557  ? 178.654 105.328 190.601 1.00 81.86  ?  557  ASP   C CA    1 
ATOM   3084 C C     . ASP   A 1 557  ? 177.892 105.065 189.313 1.00 78.23  ?  557  ASP   C C     1 
ATOM   3085 O O     . ASP   A 1 557  ? 176.894 105.728 189.018 1.00 76.64  ?  557  ASP   C O     1 
ATOM   3086 C CB    . ASP   A 1 557  ? 177.701 105.164 191.783 1.00 83.94  ?  557  ASP   C CB    1 
ATOM   3087 C CG    . ASP   A 1 557  ? 177.144 103.739 191.861 1.00 82.92  ?  557  ASP   C CG    1 
ATOM   3088 O OD1   . ASP   A 1 557  ? 177.494 102.939 191.011 1.00 77.78  ?  557  ASP   C OD1   1 
ATOM   3089 O OD2   . ASP   A 1 557  ? 176.374 103.465 192.748 1.00 82.91  -1 557  ASP   C OD2   1 
ATOM   3090 N N     . VAL   A 1 558  ? 178.380 104.107 188.538 1.00 74.18  ?  558  VAL   C N     1 
ATOM   3091 C CA    . VAL   A 1 558  ? 177.776 103.784 187.258 1.00 71.69  ?  558  VAL   C CA    1 
ATOM   3092 C C     . VAL   A 1 558  ? 176.365 103.234 187.418 1.00 71.63  ?  558  VAL   C C     1 
ATOM   3093 O O     . VAL   A 1 558  ? 175.543 103.382 186.515 1.00 70.52  ?  558  VAL   C O     1 
ATOM   3094 C CB    . VAL   A 1 558  ? 178.651 102.781 186.489 1.00 68.20  ?  558  VAL   C CB    1 
ATOM   3095 C CG1   . VAL   A 1 558  ? 178.551 101.376 187.092 1.00 74.68  ?  558  VAL   C CG1   1 
ATOM   3096 C CG2   . VAL   A 1 558  ? 178.228 102.755 185.030 1.00 67.34  ?  558  VAL   C CG2   1 
ATOM   3097 N N     . THR   A 1 559  ? 176.073 102.595 188.549 1.00 73.38  ?  559  THR   C N     1 
ATOM   3098 C CA    . THR   A 1 559  ? 174.738 102.050 188.739 1.00 73.97  ?  559  THR   C CA    1 
ATOM   3099 C C     . THR   A 1 559  ? 173.717 103.170 188.745 1.00 73.47  ?  559  THR   C C     1 
ATOM   3100 O O     . THR   A 1 559  ? 172.689 103.091 188.072 1.00 72.02  ?  559  THR   C O     1 
ATOM   3101 C CB    . THR   A 1 559  ? 174.628 101.255 190.053 1.00 77.13  ?  559  THR   C CB    1 
ATOM   3102 O OG1   . THR   A 1 559  ? 175.530 100.144 190.025 1.00 76.01  ?  559  THR   C OG1   1 
ATOM   3103 C CG2   . THR   A 1 559  ? 173.211 100.740 190.229 1.00 78.55  ?  559  THR   C CG2   1 
ATOM   3104 N N     . VAL   A 1 560  ? 174.022 104.227 189.484 1.00 73.91  ?  560  VAL   C N     1 
ATOM   3105 C CA    . VAL   A 1 560  ? 173.139 105.375 189.578 1.00 75.32  ?  560  VAL   C CA    1 
ATOM   3106 C C     . VAL   A 1 560  ? 173.017 106.046 188.219 1.00 73.29  ?  560  VAL   C C     1 
ATOM   3107 O O     . VAL   A 1 560  ? 171.940 106.494 187.821 1.00 72.73  ?  560  VAL   C O     1 
ATOM   3108 C CB    . VAL   A 1 560  ? 173.661 106.369 190.631 1.00 79.06  ?  560  VAL   C CB    1 
ATOM   3109 C CG1   . VAL   A 1 560  ? 172.842 107.655 190.598 1.00 82.26  ?  560  VAL   C CG1   1 
ATOM   3110 C CG2   . VAL   A 1 560  ? 173.579 105.721 192.006 1.00 77.85  ?  560  VAL   C CG2   1 
ATOM   3111 N N     . LEU   A 1 561  ? 174.133 106.126 187.511 1.00 71.52  ?  561  LEU   C N     1 
ATOM   3112 C CA    . LEU   A 1 561  ? 174.143 106.731 186.191 1.00 70.32  ?  561  LEU   C CA    1 
ATOM   3113 C C     . LEU   A 1 561  ? 173.206 106.003 185.230 1.00 67.65  ?  561  LEU   C C     1 
ATOM   3114 O O     . LEU   A 1 561  ? 172.403 106.629 184.539 1.00 64.82  ?  561  LEU   C O     1 
ATOM   3115 C CB    . LEU   A 1 561  ? 175.568 106.694 185.630 1.00 70.11  ?  561  LEU   C CB    1 
ATOM   3116 C CG    . LEU   A 1 561  ? 175.754 107.253 184.234 1.00 69.17  ?  561  LEU   C CG    1 
ATOM   3117 C CD1   . LEU   A 1 561  ? 175.496 108.753 184.250 1.00 67.07  ?  561  LEU   C CD1   1 
ATOM   3118 C CD2   . LEU   A 1 561  ? 177.160 106.920 183.756 1.00 72.60  ?  561  LEU   C CD2   1 
ATOM   3119 N N     . LEU   A 1 562  ? 173.313 104.679 185.189 1.00 68.04  ?  562  LEU   C N     1 
ATOM   3120 C CA    . LEU   A 1 562  ? 172.519 103.872 184.269 1.00 65.91  ?  562  LEU   C CA    1 
ATOM   3121 C C     . LEU   A 1 562  ? 171.033 103.866 184.615 1.00 65.20  ?  562  LEU   C C     1 
ATOM   3122 O O     . LEU   A 1 562  ? 170.183 103.892 183.723 1.00 63.01  ?  562  LEU   C O     1 
ATOM   3123 C CB    . LEU   A 1 562  ? 173.054 102.439 184.263 1.00 62.61  ?  562  LEU   C CB    1 
ATOM   3124 C CG    . LEU   A 1 562  ? 174.460 102.244 183.655 1.00 62.96  ?  562  LEU   C CG    1 
ATOM   3125 C CD1   . LEU   A 1 562  ? 174.936 100.838 183.973 1.00 66.88  ?  562  LEU   C CD1   1 
ATOM   3126 C CD2   . LEU   A 1 562  ? 174.420 102.466 182.140 1.00 61.24  ?  562  LEU   C CD2   1 
ATOM   3127 N N     . GLU   A 1 563  ? 170.711 103.859 185.905 1.00 67.78  ?  563  GLU   C N     1 
ATOM   3128 C CA    . GLU   A 1 563  ? 169.317 103.815 186.345 1.00 69.45  ?  563  GLU   C CA    1 
ATOM   3129 C C     . GLU   A 1 563  ? 168.512 105.021 185.878 1.00 64.72  ?  563  GLU   C C     1 
ATOM   3130 O O     . GLU   A 1 563  ? 167.289 104.952 185.764 1.00 66.86  ?  563  GLU   C O     1 
ATOM   3131 C CB    . GLU   A 1 563  ? 169.233 103.718 187.868 1.00 73.25  ?  563  GLU   C CB    1 
ATOM   3132 C CG    . GLU   A 1 563  ? 169.574 102.353 188.437 1.00 79.69  ?  563  GLU   C CG    1 
ATOM   3133 C CD    . GLU   A 1 563  ? 169.572 102.340 189.938 1.00 82.58  ?  563  GLU   C CD    1 
ATOM   3134 O OE1   . GLU   A 1 563  ? 169.367 103.379 190.519 1.00 77.24  ?  563  GLU   C OE1   1 
ATOM   3135 O OE2   . GLU   A 1 563  ? 169.776 101.293 190.505 1.00 81.81  -1 563  GLU   C OE2   1 
ATOM   3136 N N     . ASN   A 1 564  ? 169.194 106.129 185.628 1.00 60.92  ?  564  ASN   C N     1 
ATOM   3137 C CA    . ASN   A 1 564  ? 168.540 107.364 185.223 1.00 60.56  ?  564  ASN   C CA    1 
ATOM   3138 C C     . ASN   A 1 564  ? 168.695 107.629 183.725 1.00 55.65  ?  564  ASN   C C     1 
ATOM   3139 O O     . ASN   A 1 564  ? 168.419 108.729 183.246 1.00 55.50  ?  564  ASN   C O     1 
ATOM   3140 C CB    . ASN   A 1 564  ? 169.104 108.511 186.039 1.00 66.06  ?  564  ASN   C CB    1 
ATOM   3141 C CG    . ASN   A 1 564  ? 168.711 108.427 187.501 1.00 73.63  ?  564  ASN   C CG    1 
ATOM   3142 O OD1   . ASN   A 1 564  ? 167.620 108.868 187.888 1.00 72.69  ?  564  ASN   C OD1   1 
ATOM   3143 N ND2   . ASN   A 1 564  ? 169.562 107.861 188.319 1.00 73.25  ?  564  ASN   C ND2   1 
ATOM   3144 N N     . TYR   A 1 565  ? 169.139 106.617 182.986 1.00 53.79  ?  565  TYR   C N     1 
ATOM   3145 C CA    . TYR   A 1 565  ? 169.441 106.756 181.562 1.00 50.13  ?  565  TYR   C CA    1 
ATOM   3146 C C     . TYR   A 1 565  ? 168.299 107.332 180.740 1.00 44.69  ?  565  TYR   C C     1 
ATOM   3147 O O     . TYR   A 1 565  ? 168.500 108.224 179.926 1.00 46.05  ?  565  TYR   C O     1 
ATOM   3148 C CB    . TYR   A 1 565  ? 169.842 105.402 180.981 1.00 49.71  ?  565  TYR   C CB    1 
ATOM   3149 C CG    . TYR   A 1 565  ? 170.174 105.434 179.508 1.00 46.30  ?  565  TYR   C CG    1 
ATOM   3150 C CD1   . TYR   A 1 565  ? 171.423 105.855 179.097 1.00 45.94  ?  565  TYR   C CD1   1 
ATOM   3151 C CD2   . TYR   A 1 565  ? 169.238 105.042 178.570 1.00 47.04  ?  565  TYR   C CD2   1 
ATOM   3152 C CE1   . TYR   A 1 565  ? 171.742 105.875 177.759 1.00 45.42  ?  565  TYR   C CE1   1 
ATOM   3153 C CE2   . TYR   A 1 565  ? 169.561 105.068 177.226 1.00 46.89  ?  565  TYR   C CE2   1 
ATOM   3154 C CZ    . TYR   A 1 565  ? 170.805 105.476 176.824 1.00 44.42  ?  565  TYR   C CZ    1 
ATOM   3155 O OH    . TYR   A 1 565  ? 171.121 105.488 175.489 1.00 44.22  ?  565  TYR   C OH    1 
ATOM   3156 N N     . GLY   A 1 566  ? 167.099 106.815 180.918 1.00 45.00  ?  566  GLY   C N     1 
ATOM   3157 C CA    . GLY   A 1 566  ? 166.004 107.214 180.041 1.00 47.31  ?  566  GLY   C CA    1 
ATOM   3158 C C     . GLY   A 1 566  ? 165.264 108.458 180.514 1.00 46.91  ?  566  GLY   C C     1 
ATOM   3159 O O     . GLY   A 1 566  ? 164.232 108.818 179.946 1.00 46.79  ?  566  GLY   C O     1 
ATOM   3160 N N     . LYS   A 1 567  ? 165.754 109.103 181.566 1.00 47.69  ?  567  LYS   C N     1 
ATOM   3161 C CA    . LYS   A 1 567  ? 165.034 110.238 182.116 1.00 49.07  ?  567  LYS   C CA    1 
ATOM   3162 C C     . LYS   A 1 567  ? 165.354 111.558 181.421 1.00 48.65  ?  567  LYS   C C     1 
ATOM   3163 O O     . LYS   A 1 567  ? 166.516 111.952 181.287 1.00 53.18  ?  567  LYS   C O     1 
ATOM   3164 C CB    . LYS   A 1 567  ? 165.306 110.353 183.611 1.00 54.65  ?  567  LYS   C CB    1 
ATOM   3165 C CG    . LYS   A 1 567  ? 164.744 109.199 184.423 1.00 60.10  ?  567  LYS   C CG    1 
ATOM   3166 C CD    . LYS   A 1 567  ? 164.997 109.400 185.898 1.00 65.95  ?  567  LYS   C CD    1 
ATOM   3167 C CE    . LYS   A 1 567  ? 164.530 108.203 186.719 1.00 72.17  ?  567  LYS   C CE    1 
ATOM   3168 N NZ    . LYS   A 1 567  ? 164.845 108.377 188.159 1.00 72.03  1  567  LYS   C NZ    1 
ATOM   3169 N N     . PHE   A 1 568  ? 164.295 112.273 181.051 1.00 44.59  ?  568  PHE   C N     1 
ATOM   3170 C CA    . PHE   A 1 568  ? 164.389 113.607 180.468 1.00 41.43  ?  568  PHE   C CA    1 
ATOM   3171 C C     . PHE   A 1 568  ? 165.174 114.525 181.382 1.00 42.24  ?  568  PHE   C C     1 
ATOM   3172 O O     . PHE   A 1 568  ? 166.015 115.308 180.941 1.00 44.09  ?  568  PHE   C O     1 
ATOM   3173 C CB    . PHE   A 1 568  ? 162.995 114.193 180.256 1.00 40.27  ?  568  PHE   C CB    1 
ATOM   3174 C CG    . PHE   A 1 568  ? 162.984 115.606 179.731 1.00 37.71  ?  568  PHE   C CG    1 
ATOM   3175 C CD1   . PHE   A 1 568  ? 162.978 115.861 178.372 1.00 37.31  ?  568  PHE   C CD1   1 
ATOM   3176 C CD2   . PHE   A 1 568  ? 162.984 116.687 180.603 1.00 40.86  ?  568  PHE   C CD2   1 
ATOM   3177 C CE1   . PHE   A 1 568  ? 162.966 117.149 177.890 1.00 33.96  ?  568  PHE   C CE1   1 
ATOM   3178 C CE2   . PHE   A 1 568  ? 162.975 117.978 180.125 1.00 40.41  ?  568  PHE   C CE2   1 
ATOM   3179 C CZ    . PHE   A 1 568  ? 162.965 118.209 178.762 1.00 35.27  ?  568  PHE   C CZ    1 
ATOM   3180 N N     . GLU   A 1 569  ? 164.882 114.425 182.669 1.00 45.25  ?  569  GLU   C N     1 
ATOM   3181 C CA    . GLU   A 1 569  ? 165.454 115.282 183.695 1.00 52.18  ?  569  GLU   C CA    1 
ATOM   3182 C C     . GLU   A 1 569  ? 166.979 115.276 183.719 1.00 52.95  ?  569  GLU   C C     1 
ATOM   3183 O O     . GLU   A 1 569  ? 167.590 116.215 184.231 1.00 59.35  ?  569  GLU   C O     1 
ATOM   3184 C CB    . GLU   A 1 569  ? 164.933 114.855 185.069 1.00 57.83  ?  569  GLU   C CB    1 
ATOM   3185 C CG    . GLU   A 1 569  ? 163.439 115.072 185.284 1.00 62.66  ?  569  GLU   C CG    1 
ATOM   3186 C CD    . GLU   A 1 569  ? 162.571 113.934 184.795 1.00 62.92  ?  569  GLU   C CD    1 
ATOM   3187 O OE1   . GLU   A 1 569  ? 163.020 113.169 183.974 1.00 58.18  ?  569  GLU   C OE1   1 
ATOM   3188 O OE2   . GLU   A 1 569  ? 161.456 113.836 185.247 1.00 59.69  -1 569  GLU   C OE2   1 
ATOM   3189 N N     . LYS   A 1 570  ? 167.600 114.212 183.217 1.00 47.21  ?  570  LYS   C N     1 
ATOM   3190 C CA    . LYS   A 1 570  ? 169.054 114.121 183.239 1.00 47.69  ?  570  LYS   C CA    1 
ATOM   3191 C C     . LYS   A 1 570  ? 169.636 114.278 181.840 1.00 47.06  ?  570  LYS   C C     1 
ATOM   3192 O O     . LYS   A 1 570  ? 170.833 114.088 181.626 1.00 49.74  ?  570  LYS   C O     1 
ATOM   3193 C CB    . LYS   A 1 570  ? 169.494 112.802 183.872 1.00 53.64  ?  570  LYS   C CB    1 
ATOM   3194 C CG    . LYS   A 1 570  ? 169.014 112.606 185.318 1.00 58.15  ?  570  LYS   C CG    1 
ATOM   3195 C CD    . LYS   A 1 570  ? 169.588 113.673 186.253 1.00 61.94  ?  570  LYS   C CD    1 
ATOM   3196 C CE    . LYS   A 1 570  ? 169.234 113.406 187.713 1.00 68.78  ?  570  LYS   C CE    1 
ATOM   3197 N NZ    . LYS   A 1 570  ? 167.795 113.639 187.995 1.00 70.12  1  570  LYS   C NZ    1 
ATOM   3198 N N     . GLY   A 1 571  ? 168.778 114.624 180.884 1.00 44.91  ?  571  GLY   C N     1 
ATOM   3199 C CA    . GLY   A 1 571  ? 169.196 114.831 179.506 1.00 42.49  ?  571  GLY   C CA    1 
ATOM   3200 C C     . GLY   A 1 571  ? 169.382 113.525 178.753 1.00 39.53  ?  571  GLY   C C     1 
ATOM   3201 O O     . GLY   A 1 571  ? 170.115 113.482 177.766 1.00 41.40  ?  571  GLY   C O     1 
ATOM   3202 N N     . TYR   A 1 572  ? 168.744 112.458 179.236 1.00 41.92  ?  572  TYR   C N     1 
ATOM   3203 C CA    . TYR   A 1 572  ? 168.803 111.125 178.637 1.00 41.27  ?  572  TYR   C CA    1 
ATOM   3204 C C     . TYR   A 1 572  ? 170.171 110.441 178.735 1.00 41.21  ?  572  TYR   C C     1 
ATOM   3205 O O     . TYR   A 1 572  ? 170.299 109.260 178.418 1.00 45.14  ?  572  TYR   C O     1 
ATOM   3206 C CB    . TYR   A 1 572  ? 168.337 111.182 177.183 1.00 37.96  ?  572  TYR   C CB    1 
ATOM   3207 C CG    . TYR   A 1 572  ? 166.939 111.704 177.022 1.00 37.24  ?  572  TYR   C CG    1 
ATOM   3208 C CD1   . TYR   A 1 572  ? 166.719 113.027 176.682 1.00 35.33  ?  572  TYR   C CD1   1 
ATOM   3209 C CD2   . TYR   A 1 572  ? 165.874 110.851 177.205 1.00 43.13  ?  572  TYR   C CD2   1 
ATOM   3210 C CE1   . TYR   A 1 572  ? 165.432 113.487 176.524 1.00 37.38  ?  572  TYR   C CE1   1 
ATOM   3211 C CE2   . TYR   A 1 572  ? 164.594 111.311 177.046 1.00 44.60  ?  572  TYR   C CE2   1 
ATOM   3212 C CZ    . TYR   A 1 572  ? 164.371 112.619 176.708 1.00 39.16  ?  572  TYR   C CZ    1 
ATOM   3213 O OH    . TYR   A 1 572  ? 163.091 113.063 176.540 1.00 40.65  ?  572  TYR   C OH    1 
ATOM   3214 N N     . LEU   A 1 573  ? 171.200 111.176 179.138 1.00 37.54  ?  573  LEU   C N     1 
ATOM   3215 C CA    . LEU   A 1 573  ? 172.522 110.598 179.362 1.00 41.59  ?  573  LEU   C CA    1 
ATOM   3216 C C     . LEU   A 1 573  ? 172.983 109.698 178.218 1.00 46.96  ?  573  LEU   C C     1 
ATOM   3217 O O     . LEU   A 1 573  ? 173.713 108.729 178.440 1.00 47.47  ?  573  LEU   C O     1 
ATOM   3218 C CB    . LEU   A 1 573  ? 172.496 109.782 180.657 1.00 40.77  ?  573  LEU   C CB    1 
ATOM   3219 C CG    . LEU   A 1 573  ? 172.072 110.544 181.916 1.00 48.97  ?  573  LEU   C CG    1 
ATOM   3220 C CD1   . LEU   A 1 573  ? 171.922 109.566 183.066 1.00 59.39  ?  573  LEU   C CD1   1 
ATOM   3221 C CD2   . LEU   A 1 573  ? 173.113 111.593 182.245 1.00 52.23  ?  573  LEU   C CD2   1 
ATOM   3222 N N     . ILE   A 1 574  ? 172.561 109.999 176.996 1.00 42.80  ?  574  ILE   C N     1 
ATOM   3223 C CA    . ILE   A 1 574  ? 172.840 109.106 175.885 1.00 38.32  ?  574  ILE   C CA    1 
ATOM   3224 C C     . ILE   A 1 574  ? 174.302 109.046 175.558 1.00 38.52  ?  574  ILE   C C     1 
ATOM   3225 O O     . ILE   A 1 574  ? 174.847 107.964 175.337 1.00 42.20  ?  574  ILE   C O     1 
ATOM   3226 C CB    . ILE   A 1 574  ? 172.041 109.502 174.641 1.00 34.99  ?  574  ILE   C CB    1 
ATOM   3227 C CG1   . ILE   A 1 574  ? 170.582 109.220 174.910 1.00 35.02  ?  574  ILE   C CG1   1 
ATOM   3228 C CG2   . ILE   A 1 574  ? 172.547 108.741 173.406 1.00 39.20  ?  574  ILE   C CG2   1 
ATOM   3229 C CD1   . ILE   A 1 574  ? 169.650 109.839 173.934 1.00 35.49  ?  574  ILE   C CD1   1 
ATOM   3230 N N     . PHE   A 1 575  ? 174.942 110.198 175.500 1.00 37.84  ?  575  PHE   C N     1 
ATOM   3231 C CA    . PHE   A 1 575  ? 176.340 110.212 175.143 1.00 43.08  ?  575  PHE   C CA    1 
ATOM   3232 C C     . PHE   A 1 575  ? 177.189 109.898 176.351 1.00 46.81  ?  575  PHE   C C     1 
ATOM   3233 O O     . PHE   A 1 575  ? 178.269 109.328 176.222 1.00 51.24  ?  575  PHE   C O     1 
ATOM   3234 C CB    . PHE   A 1 575  ? 176.724 111.534 174.504 1.00 42.80  ?  575  PHE   C CB    1 
ATOM   3235 C CG    . PHE   A 1 575  ? 176.189 111.663 173.135 1.00 35.77  ?  575  PHE   C CG    1 
ATOM   3236 C CD1   . PHE   A 1 575  ? 175.019 112.349 172.906 1.00 33.93  ?  575  PHE   C CD1   1 
ATOM   3237 C CD2   . PHE   A 1 575  ? 176.850 111.090 172.066 1.00 33.85  ?  575  PHE   C CD2   1 
ATOM   3238 C CE1   . PHE   A 1 575  ? 174.512 112.464 171.638 1.00 28.10  ?  575  PHE   C CE1   1 
ATOM   3239 C CE2   . PHE   A 1 575  ? 176.347 111.204 170.792 1.00 36.60  ?  575  PHE   C CE2   1 
ATOM   3240 C CZ    . PHE   A 1 575  ? 175.176 111.892 170.578 1.00 33.74  ?  575  PHE   C CZ    1 
ATOM   3241 N N     . VAL   A 1 576  ? 176.687 110.198 177.540 1.00 42.88  ?  576  VAL   C N     1 
ATOM   3242 C CA    . VAL   A 1 576  ? 177.479 109.880 178.713 1.00 44.55  ?  576  VAL   C CA    1 
ATOM   3243 C C     . VAL   A 1 576  ? 177.716 108.377 178.758 1.00 47.38  ?  576  VAL   C C     1 
ATOM   3244 O O     . VAL   A 1 576  ? 178.842 107.921 178.949 1.00 51.20  ?  576  VAL   C O     1 
ATOM   3245 C CB    . VAL   A 1 576  ? 176.790 110.319 180.019 1.00 46.48  ?  576  VAL   C CB    1 
ATOM   3246 C CG1   . VAL   A 1 576  ? 177.589 109.817 181.210 1.00 53.22  ?  576  VAL   C CG1   1 
ATOM   3247 C CG2   . VAL   A 1 576  ? 176.672 111.817 180.062 1.00 57.08  ?  576  VAL   C CG2   1 
ATOM   3248 N N     . VAL   A 1 577  ? 176.660 107.601 178.548 1.00 46.33  ?  577  VAL   C N     1 
ATOM   3249 C CA    . VAL   A 1 577  ? 176.810 106.157 178.555 1.00 45.67  ?  577  VAL   C CA    1 
ATOM   3250 C C     . VAL   A 1 577  ? 177.475 105.653 177.280 1.00 45.88  ?  577  VAL   C C     1 
ATOM   3251 O O     . VAL   A 1 577  ? 178.387 104.830 177.342 1.00 48.98  ?  577  VAL   C O     1 
ATOM   3252 C CB    . VAL   A 1 577  ? 175.455 105.476 178.779 1.00 41.87  ?  577  VAL   C CB    1 
ATOM   3253 C CG1   . VAL   A 1 577  ? 175.581 103.976 178.597 1.00 45.41  ?  577  VAL   C CG1   1 
ATOM   3254 C CG2   . VAL   A 1 577  ? 174.981 105.800 180.193 1.00 54.12  ?  577  VAL   C CG2   1 
ATOM   3255 N N     . ARG   A 1 578  ? 177.047 106.148 176.124 1.00 43.95  ?  578  ARG   C N     1 
ATOM   3256 C CA    . ARG   A 1 578  ? 177.648 105.700 174.875 1.00 41.60  ?  578  ARG   C CA    1 
ATOM   3257 C C     . ARG   A 1 578  ? 179.162 105.885 174.896 1.00 41.01  ?  578  ARG   C C     1 
ATOM   3258 O O     . ARG   A 1 578  ? 179.906 104.997 174.477 1.00 44.81  ?  578  ARG   C O     1 
ATOM   3259 C CB    . ARG   A 1 578  ? 177.061 106.447 173.692 1.00 37.29  ?  578  ARG   C CB    1 
ATOM   3260 C CG    . ARG   A 1 578  ? 177.557 105.979 172.339 1.00 36.43  ?  578  ARG   C CG    1 
ATOM   3261 C CD    . ARG   A 1 578  ? 176.945 106.736 171.218 1.00 32.04  ?  578  ARG   C CD    1 
ATOM   3262 N NE    . ARG   A 1 578  ? 175.510 106.520 171.130 1.00 27.19  ?  578  ARG   C NE    1 
ATOM   3263 C CZ    . ARG   A 1 578  ? 174.692 107.129 170.249 1.00 27.61  ?  578  ARG   C CZ    1 
ATOM   3264 N NH1   . ARG   A 1 578  ? 175.175 107.989 169.380 1.00 31.92  1  578  ARG   C NH1   1 
ATOM   3265 N NH2   . ARG   A 1 578  ? 173.400 106.859 170.261 1.00 30.21  ?  578  ARG   C NH2   1 
ATOM   3266 N N     . PHE   A 1 579  ? 179.624 107.023 175.405 1.00 42.51  ?  579  PHE   C N     1 
ATOM   3267 C CA    . PHE   A 1 579  ? 181.053 107.251 175.513 1.00 45.06  ?  579  PHE   C CA    1 
ATOM   3268 C C     . PHE   A 1 579  ? 181.649 106.357 176.587 1.00 47.86  ?  579  PHE   C C     1 
ATOM   3269 O O     . PHE   A 1 579  ? 182.721 105.786 176.396 1.00 50.38  ?  579  PHE   C O     1 
ATOM   3270 C CB    . PHE   A 1 579  ? 181.362 108.716 175.818 1.00 47.83  ?  579  PHE   C CB    1 
ATOM   3271 C CG    . PHE   A 1 579  ? 181.225 109.643 174.632 1.00 45.24  ?  579  PHE   C CG    1 
ATOM   3272 C CD1   . PHE   A 1 579  ? 180.440 110.775 174.703 1.00 45.54  ?  579  PHE   C CD1   1 
ATOM   3273 C CD2   . PHE   A 1 579  ? 181.892 109.387 173.450 1.00 45.04  ?  579  PHE   C CD2   1 
ATOM   3274 C CE1   . PHE   A 1 579  ? 180.329 111.625 173.627 1.00 44.40  ?  579  PHE   C CE1   1 
ATOM   3275 C CE2   . PHE   A 1 579  ? 181.780 110.235 172.376 1.00 46.97  ?  579  PHE   C CE2   1 
ATOM   3276 C CZ    . PHE   A 1 579  ? 180.997 111.354 172.465 1.00 46.84  ?  579  PHE   C CZ    1 
ATOM   3277 N N     . LEU   A 1 580  ? 180.942 106.185 177.702 1.00 47.19  ?  580  LEU   C N     1 
ATOM   3278 C CA    . LEU   A 1 580  ? 181.445 105.318 178.757 1.00 50.16  ?  580  LEU   C CA    1 
ATOM   3279 C C     . LEU   A 1 580  ? 181.742 103.933 178.195 1.00 52.97  ?  580  LEU   C C     1 
ATOM   3280 O O     . LEU   A 1 580  ? 182.744 103.321 178.551 1.00 57.26  ?  580  LEU   C O     1 
ATOM   3281 C CB    . LEU   A 1 580  ? 180.431 105.217 179.905 1.00 45.69  ?  580  LEU   C CB    1 
ATOM   3282 C CG    . LEU   A 1 580  ? 180.855 104.389 181.134 1.00 50.91  ?  580  LEU   C CG    1 
ATOM   3283 C CD1   . LEU   A 1 580  ? 182.079 105.024 181.799 1.00 61.87  ?  580  LEU   C CD1   1 
ATOM   3284 C CD2   . LEU   A 1 580  ? 179.689 104.322 182.106 1.00 60.91  ?  580  LEU   C CD2   1 
ATOM   3285 N N     . PHE   A 1 581  ? 180.890 103.445 177.293 1.00 50.50  ?  581  PHE   C N     1 
ATOM   3286 C CA    . PHE   A 1 581  ? 181.153 102.165 176.643 1.00 49.81  ?  581  PHE   C CA    1 
ATOM   3287 C C     . PHE   A 1 581  ? 182.419 102.240 175.807 1.00 51.30  ?  581  PHE   C C     1 
ATOM   3288 O O     . PHE   A 1 581  ? 183.298 101.388 175.910 1.00 57.39  ?  581  PHE   C O     1 
ATOM   3289 C CB    . PHE   A 1 581  ? 180.005 101.766 175.709 1.00 48.72  ?  581  PHE   C CB    1 
ATOM   3290 C CG    . PHE   A 1 581  ? 178.905 100.969 176.316 1.00 45.54  ?  581  PHE   C CG    1 
ATOM   3291 C CD1   . PHE   A 1 581  ? 177.765 101.577 176.807 1.00 48.62  ?  581  PHE   C CD1   1 
ATOM   3292 C CD2   . PHE   A 1 581  ? 178.995 99.592  176.365 1.00 47.71  ?  581  PHE   C CD2   1 
ATOM   3293 C CE1   . PHE   A 1 581  ? 176.741 100.822 177.339 1.00 48.52  ?  581  PHE   C CE1   1 
ATOM   3294 C CE2   . PHE   A 1 581  ? 177.980 98.845  176.895 1.00 53.54  ?  581  PHE   C CE2   1 
ATOM   3295 C CZ    . PHE   A 1 581  ? 176.850 99.456  177.382 1.00 50.27  ?  581  PHE   C CZ    1 
ATOM   3296 N N     . GLY   A 1 582  ? 182.523 103.282 174.990 1.00 48.62  ?  582  GLY   C N     1 
ATOM   3297 C CA    . GLY   A 1 582  ? 183.663 103.452 174.098 1.00 51.37  ?  582  GLY   C CA    1 
ATOM   3298 C C     . GLY   A 1 582  ? 184.986 103.597 174.840 1.00 56.06  ?  582  GLY   C C     1 
ATOM   3299 O O     . GLY   A 1 582  ? 186.033 103.176 174.346 1.00 59.59  ?  582  GLY   C O     1 
ATOM   3300 N N     . LEU   A 1 583  ? 184.940 104.177 176.032 1.00 55.40  ?  583  LEU   C N     1 
ATOM   3301 C CA    . LEU   A 1 583  ? 186.141 104.421 176.818 1.00 57.54  ?  583  LEU   C CA    1 
ATOM   3302 C C     . LEU   A 1 583  ? 186.632 103.179 177.557 1.00 61.79  ?  583  LEU   C C     1 
ATOM   3303 O O     . LEU   A 1 583  ? 187.690 103.207 178.188 1.00 69.96  ?  583  LEU   C O     1 
ATOM   3304 C CB    . LEU   A 1 583  ? 185.870 105.544 177.823 1.00 57.11  ?  583  LEU   C CB    1 
ATOM   3305 C CG    . LEU   A 1 583  ? 185.587 106.943 177.237 1.00 54.70  ?  583  LEU   C CG    1 
ATOM   3306 C CD1   . LEU   A 1 583  ? 185.096 107.862 178.354 1.00 61.86  ?  583  LEU   C CD1   1 
ATOM   3307 C CD2   . LEU   A 1 583  ? 186.854 107.499 176.617 1.00 57.45  ?  583  LEU   C CD2   1 
ATOM   3308 N N     . VAL   A 1 584  ? 185.873 102.093 177.483 1.00 59.62  ?  584  VAL   C N     1 
ATOM   3309 C CA    . VAL   A 1 584  ? 186.264 100.849 178.129 1.00 66.00  ?  584  VAL   C CA    1 
ATOM   3310 C C     . VAL   A 1 584  ? 186.803 99.862  177.107 1.00 76.13  ?  584  VAL   C C     1 
ATOM   3311 O O     . VAL   A 1 584  ? 186.082 99.407  176.221 1.00 74.98  ?  584  VAL   C O     1 
ATOM   3312 C CB    . VAL   A 1 584  ? 185.064 100.239 178.874 1.00 66.42  ?  584  VAL   C CB    1 
ATOM   3313 C CG1   . VAL   A 1 584  ? 185.426 98.884  179.467 1.00 76.23  ?  584  VAL   C CG1   1 
ATOM   3314 C CG2   . VAL   A 1 584  ? 184.646 101.186 179.992 1.00 70.25  ?  584  VAL   C CG2   1 
ATOM   3315 N N     . ASN   A 1 585  ? 188.083 99.543  177.225 1.00 87.17  ?  585  ASN   C N     1 
ATOM   3316 C CA    . ASN   A 1 585  ? 188.733 98.628  176.298 1.00 94.31  ?  585  ASN   C CA    1 
ATOM   3317 C C     . ASN   A 1 585  ? 190.075 98.175  176.852 1.00 103.05 ?  585  ASN   C C     1 
ATOM   3318 O O     . ASN   A 1 585  ? 190.504 98.630  177.913 1.00 105.86 ?  585  ASN   C O     1 
ATOM   3319 C CB    . ASN   A 1 585  ? 188.899 99.291  174.935 1.00 94.07  ?  585  ASN   C CB    1 
ATOM   3320 C CG    . ASN   A 1 585  ? 188.888 98.310  173.781 1.00 98.62  ?  585  ASN   C CG    1 
ATOM   3321 O OD1   . ASN   A 1 585  ? 189.639 97.324  173.773 1.00 105.07 ?  585  ASN   C OD1   1 
ATOM   3322 N ND2   . ASN   A 1 585  ? 188.051 98.562  172.809 1.00 80.61  ?  585  ASN   C ND2   1 
ATOM   3323 N N     . GLN   A 1 586  ? 190.752 97.311  176.107 1.00 111.12 ?  586  GLN   C N     1 
ATOM   3324 C CA    . GLN   A 1 586  ? 192.101 96.887  176.436 1.00 113.58 ?  586  GLN   C CA    1 
ATOM   3325 C C     . GLN   A 1 586  ? 193.087 97.470  175.436 1.00 114.73 ?  586  GLN   C C     1 
ATOM   3326 O O     . GLN   A 1 586  ? 194.259 97.680  175.748 1.00 118.10 ?  586  GLN   C O     1 
ATOM   3327 C CB    . GLN   A 1 586  ? 192.195 95.362  176.447 1.00 113.74 ?  586  GLN   C CB    1 
ATOM   3328 C CG    . GLN   A 1 586  ? 191.279 94.701  177.456 1.00 114.01 ?  586  GLN   C CG    1 
ATOM   3329 C CD    . GLN   A 1 586  ? 191.617 95.102  178.876 1.00 118.95 ?  586  GLN   C CD    1 
ATOM   3330 O OE1   . GLN   A 1 586  ? 192.750 94.928  179.330 1.00 115.20 ?  586  GLN   C OE1   1 
ATOM   3331 N NE2   . GLN   A 1 586  ? 190.639 95.649  179.584 1.00 113.66 ?  586  GLN   C NE2   1 
ATOM   3332 N N     . GLU   A 1 587  ? 192.604 97.738  174.225 1.00 120.00 ?  587  GLU   C N     1 
ATOM   3333 C CA    . GLU   A 1 587  ? 193.464 98.247  173.164 1.00 127.04 ?  587  GLU   C CA    1 
ATOM   3334 C C     . GLU   A 1 587  ? 193.607 99.753  173.279 1.00 123.06 ?  587  GLU   C C     1 
ATOM   3335 O O     . GLU   A 1 587  ? 193.079 100.511 172.465 1.00 127.19 ?  587  GLU   C O     1 
ATOM   3336 C CB    . GLU   A 1 587  ? 192.913 97.874  171.786 1.00 129.04 ?  587  GLU   C CB    1 
ATOM   3337 C CG    . GLU   A 1 587  ? 192.866 96.376  171.516 1.00 131.72 ?  587  GLU   C CG    1 
ATOM   3338 C CD    . GLU   A 1 587  ? 192.444 96.040  170.110 1.00 138.74 ?  587  GLU   C CD    1 
ATOM   3339 O OE1   . GLU   A 1 587  ? 192.154 96.943  169.362 1.00 140.57 ?  587  GLU   C OE1   1 
ATOM   3340 O OE2   . GLU   A 1 587  ? 192.417 94.877  169.783 1.00 140.96 -1 587  GLU   C OE2   1 
ATOM   3341 N N     . ARG   A 1 588  ? 194.310 100.175 174.318 1.00 128.87 ?  588  ARG   C N     1 
ATOM   3342 C CA    . ARG   A 1 588  ? 194.482 101.584 174.627 1.00 125.30 ?  588  ARG   C CA    1 
ATOM   3343 C C     . ARG   A 1 588  ? 195.956 101.942 174.721 1.00 124.28 ?  588  ARG   C C     1 
ATOM   3344 O O     . ARG   A 1 588  ? 196.808 101.070 174.888 1.00 137.26 ?  588  ARG   C O     1 
ATOM   3345 C CB    . ARG   A 1 588  ? 193.767 101.928 175.917 1.00 129.20 ?  588  ARG   C CB    1 
ATOM   3346 C CG    . ARG   A 1 588  ? 192.254 101.795 175.832 1.00 118.42 ?  588  ARG   C CG    1 
ATOM   3347 C CD    . ARG   A 1 588  ? 191.583 102.173 177.091 1.00 116.14 ?  588  ARG   C CD    1 
ATOM   3348 N NE    . ARG   A 1 588  ? 191.919 101.260 178.177 1.00 115.43 ?  588  ARG   C NE    1 
ATOM   3349 C CZ    . ARG   A 1 588  ? 192.727 101.553 179.222 1.00 125.89 ?  588  ARG   C CZ    1 
ATOM   3350 N NH1   . ARG   A 1 588  ? 193.283 102.745 179.328 1.00 124.39 1  588  ARG   C NH1   1 
ATOM   3351 N NH2   . ARG   A 1 588  ? 192.957 100.634 180.144 1.00 121.94 ?  588  ARG   C NH2   1 
ATOM   3352 N N     . THR   A 1 589  ? 196.256 103.226 174.587 1.00 147.58 ?  589  THR   C N     1 
ATOM   3353 C CA    . THR   A 1 589  ? 197.630 103.704 174.612 1.00 130.07 ?  589  THR   C CA    1 
ATOM   3354 C C     . THR   A 1 589  ? 197.795 104.895 175.546 1.00 137.38 ?  589  THR   C C     1 
ATOM   3355 O O     . THR   A 1 589  ? 197.077 105.017 176.538 1.00 137.65 ?  589  THR   C O     1 
ATOM   3356 C CB    . THR   A 1 589  ? 198.100 104.055 173.185 1.00 136.01 ?  589  THR   C CB    1 
ATOM   3357 O OG1   . THR   A 1 589  ? 199.498 104.366 173.205 1.00 137.89 ?  589  THR   C OG1   1 
ATOM   3358 C CG2   . THR   A 1 589  ? 197.299 105.228 172.607 1.00 139.13 ?  589  THR   C CG2   1 
ATOM   3359 N N     . SER   A 1 590  ? 198.779 105.737 175.256 1.00 138.42 ?  590  SER   C N     1 
ATOM   3360 C CA    . SER   A 1 590  ? 199.057 106.908 176.065 1.00 135.96 ?  590  SER   C CA    1 
ATOM   3361 C C     . SER   A 1 590  ? 198.124 108.041 175.680 1.00 160.34 ?  590  SER   C C     1 
ATOM   3362 O O     . SER   A 1 590  ? 197.068 107.812 175.095 1.00 119.56 ?  590  SER   C O     1 
ATOM   3363 C CB    . SER   A 1 590  ? 200.500 107.337 175.886 1.00 139.33 ?  590  SER   C CB    1 
ATOM   3364 O OG    . SER   A 1 590  ? 200.795 108.467 176.664 1.00 140.05 ?  590  SER   C OG    1 
ATOM   3365 N N     . TYR   A 1 591  ? 198.515 109.264 176.005 1.00 124.21 ?  591  TYR   C N     1 
ATOM   3366 C CA    . TYR   A 1 591  ? 197.734 110.442 175.649 1.00 128.23 ?  591  TYR   C CA    1 
ATOM   3367 C C     . TYR   A 1 591  ? 196.378 110.510 176.344 1.00 125.18 ?  591  TYR   C C     1 
ATOM   3368 O O     . TYR   A 1 591  ? 195.352 110.148 175.766 1.00 130.42 ?  591  TYR   C O     1 
ATOM   3369 C CB    . TYR   A 1 591  ? 197.532 110.510 174.140 1.00 133.43 ?  591  TYR   C CB    1 
ATOM   3370 C CG    . TYR   A 1 591  ? 198.796 110.282 173.351 1.00 132.17 ?  591  TYR   C CG    1 
ATOM   3371 C CD1   . TYR   A 1 591  ? 198.990 109.101 172.639 1.00 137.78 ?  591  TYR   C CD1   1 
ATOM   3372 C CD2   . TYR   A 1 591  ? 199.767 111.256 173.346 1.00 139.85 ?  591  TYR   C CD2   1 
ATOM   3373 C CE1   . TYR   A 1 591  ? 200.158 108.915 171.934 1.00 143.28 ?  591  TYR   C CE1   1 
ATOM   3374 C CE2   . TYR   A 1 591  ? 200.932 111.075 172.643 1.00 146.71 ?  591  TYR   C CE2   1 
ATOM   3375 C CZ    . TYR   A 1 591  ? 201.131 109.907 171.938 1.00 150.24 ?  591  TYR   C CZ    1 
ATOM   3376 O OH    . TYR   A 1 591  ? 202.293 109.712 171.233 1.00 147.20 ?  591  TYR   C OH    1 
ATOM   3377 N N     . LEU   A 1 592  ? 196.385 110.975 177.590 1.00 126.73 ?  592  LEU   C N     1 
ATOM   3378 C CA    . LEU   A 1 592  ? 195.177 111.208 178.390 1.00 122.03 ?  592  LEU   C CA    1 
ATOM   3379 C C     . LEU   A 1 592  ? 194.501 109.930 178.892 1.00 118.28 ?  592  LEU   C C     1 
ATOM   3380 O O     . LEU   A 1 592  ? 194.289 109.776 180.094 1.00 117.31 ?  592  LEU   C O     1 
ATOM   3381 C CB    . LEU   A 1 592  ? 194.144 112.011 177.577 1.00 122.85 ?  592  LEU   C CB    1 
ATOM   3382 C CG    . LEU   A 1 592  ? 194.590 113.395 177.059 1.00 113.73 ?  592  LEU   C CG    1 
ATOM   3383 C CD1   . LEU   A 1 592  ? 193.485 113.961 176.177 1.00 98.74  ?  592  LEU   C CD1   1 
ATOM   3384 C CD2   . LEU   A 1 592  ? 194.886 114.318 178.224 1.00 117.46 ?  592  LEU   C CD2   1 
ATOM   3385 N N     . GLU   A 1 593  ? 194.161 109.015 177.987 1.00 124.04 ?  593  GLU   C N     1 
ATOM   3386 C CA    . GLU   A 1 593  ? 193.422 107.811 178.377 1.00 128.49 ?  593  GLU   C CA    1 
ATOM   3387 C C     . GLU   A 1 593  ? 194.229 106.904 179.309 1.00 124.62 ?  593  GLU   C C     1 
ATOM   3388 O O     . GLU   A 1 593  ? 193.687 106.001 179.947 1.00 114.24 ?  593  GLU   C O     1 
ATOM   3389 C CB    . GLU   A 1 593  ? 192.932 107.035 177.149 1.00 120.24 ?  593  GLU   C CB    1 
ATOM   3390 C CG    . GLU   A 1 593  ? 194.000 106.365 176.301 1.00 127.00 ?  593  GLU   C CG    1 
ATOM   3391 C CD    . GLU   A 1 593  ? 193.389 105.619 175.128 1.00 122.29 ?  593  GLU   C CD    1 
ATOM   3392 O OE1   . GLU   A 1 593  ? 192.184 105.562 175.056 1.00 125.95 ?  593  GLU   C OE1   1 
ATOM   3393 O OE2   . GLU   A 1 593  ? 194.121 105.102 174.312 1.00 138.65 -1 593  GLU   C OE2   1 
ATOM   3394 N N     . LYS   A 1 594  ? 195.528 107.152 179.397 1.00 109.38 ?  594  LYS   C N     1 
ATOM   3395 C CA    . LYS   A 1 594  ? 196.407 106.386 180.275 1.00 122.07 ?  594  LYS   C CA    1 
ATOM   3396 C C     . LYS   A 1 594  ? 196.125 106.669 181.740 1.00 118.94 ?  594  LYS   C C     1 
ATOM   3397 O O     . LYS   A 1 594  ? 196.605 105.956 182.621 1.00 117.06 ?  594  LYS   C O     1 
ATOM   3398 C CB    . LYS   A 1 594  ? 197.872 106.696 180.000 1.00 128.03 ?  594  LYS   C CB    1 
ATOM   3399 C CG    . LYS   A 1 594  ? 198.323 108.098 180.428 1.00 130.12 ?  594  LYS   C CG    1 
ATOM   3400 C CD    . LYS   A 1 594  ? 199.814 108.291 180.168 1.00 135.71 ?  594  LYS   C CD    1 
ATOM   3401 C CE    . LYS   A 1 594  ? 200.295 109.648 180.677 1.00 139.73 ?  594  LYS   C CE    1 
ATOM   3402 N NZ    . LYS   A 1 594  ? 201.753 109.840 180.456 1.00 140.98 1  594  LYS   C NZ    1 
ATOM   3403 N N     . LYS   A 1 595  ? 195.372 107.729 182.001 1.00 120.17 ?  595  LYS   C N     1 
ATOM   3404 C CA    . LYS   A 1 595  ? 195.085 108.153 183.362 1.00 118.14 ?  595  LYS   C CA    1 
ATOM   3405 C C     . LYS   A 1 595  ? 193.892 107.418 183.947 1.00 113.25 ?  595  LYS   C C     1 
ATOM   3406 O O     . LYS   A 1 595  ? 193.500 107.672 185.086 1.00 110.63 ?  595  LYS   C O     1 
ATOM   3407 C CB    . LYS   A 1 595  ? 194.812 109.651 183.410 1.00 120.69 ?  595  LYS   C CB    1 
ATOM   3408 C CG    . LYS   A 1 595  ? 195.996 110.529 183.061 1.00 123.23 ?  595  LYS   C CG    1 
ATOM   3409 C CD    . LYS   A 1 595  ? 195.612 111.996 183.167 1.00 122.17 ?  595  LYS   C CD    1 
ATOM   3410 C CE    . LYS   A 1 595  ? 196.784 112.919 182.895 1.00 124.43 ?  595  LYS   C CE    1 
ATOM   3411 N NZ    . LYS   A 1 595  ? 197.816 112.844 183.965 1.00 124.44 1  595  LYS   C NZ    1 
ATOM   3412 N N     . LEU   A 1 596  ? 193.297 106.525 183.166 1.00 115.41 ?  596  LEU   C N     1 
ATOM   3413 C CA    . LEU   A 1 596  ? 192.117 105.800 183.609 1.00 106.81 ?  596  LEU   C CA    1 
ATOM   3414 C C     . LEU   A 1 596  ? 192.519 104.566 184.402 1.00 106.96 ?  596  LEU   C C     1 
ATOM   3415 O O     . LEU   A 1 596  ? 193.498 103.894 184.075 1.00 108.59 ?  596  LEU   C O     1 
ATOM   3416 C CB    . LEU   A 1 596  ? 191.265 105.419 182.393 1.00 107.46 ?  596  LEU   C CB    1 
ATOM   3417 C CG    . LEU   A 1 596  ? 190.328 106.527 181.853 1.00 100.19 ?  596  LEU   C CG    1 
ATOM   3418 C CD1   . LEU   A 1 596  ? 191.116 107.815 181.624 1.00 108.40 ?  596  LEU   C CD1   1 
ATOM   3419 C CD2   . LEU   A 1 596  ? 189.709 106.048 180.547 1.00 95.69  ?  596  LEU   C CD2   1 
ATOM   3420 N N     . SER   A 1 597  ? 191.767 104.282 185.458 1.00 105.04 ?  597  SER   C N     1 
ATOM   3421 C CA    . SER   A 1 597  ? 192.087 103.159 186.332 1.00 105.01 ?  597  SER   C CA    1 
ATOM   3422 C C     . SER   A 1 597  ? 191.608 101.831 185.768 1.00 99.65  ?  597  SER   C C     1 
ATOM   3423 O O     . SER   A 1 597  ? 190.468 101.701 185.316 1.00 97.07  ?  597  SER   C O     1 
ATOM   3424 C CB    . SER   A 1 597  ? 191.489 103.385 187.703 1.00 103.45 ?  597  SER   C CB    1 
ATOM   3425 O OG    . SER   A 1 597  ? 192.093 104.483 188.334 1.00 104.29 ?  597  SER   C OG    1 
ATOM   3426 N N     . CYS   A 1 598  ? 192.487 100.835 185.806 1.00 102.34 ?  598  CYS   C N     1 
ATOM   3427 C CA    . CYS   A 1 598  ? 192.168 99.510  185.295 1.00 104.00 ?  598  CYS   C CA    1 
ATOM   3428 C C     . CYS   A 1 598  ? 191.062 98.846  186.094 1.00 99.39  ?  598  CYS   C C     1 
ATOM   3429 O O     . CYS   A 1 598  ? 190.145 98.260  185.522 1.00 100.00 ?  598  CYS   C O     1 
ATOM   3430 C CB    . CYS   A 1 598  ? 193.397 98.609  185.317 1.00 101.39 ?  598  CYS   C CB    1 
ATOM   3431 S SG    . CYS   A 1 598  ? 193.100 96.975  184.614 1.00 141.38 ?  598  CYS   C SG    1 
ATOM   3432 N N     . LYS   A 1 599  ? 191.161 98.910  187.419 1.00 105.22 ?  599  LYS   C N     1 
ATOM   3433 C CA    . LYS   A 1 599  ? 190.176 98.239  188.257 1.00 97.44  ?  599  LYS   C CA    1 
ATOM   3434 C C     . LYS   A 1 599  ? 188.790 98.815  188.032 1.00 96.64  ?  599  LYS   C C     1 
ATOM   3435 O O     . LYS   A 1 599  ? 187.810 98.073  187.956 1.00 92.18  ?  599  LYS   C O     1 
ATOM   3436 C CB    . LYS   A 1 599  ? 190.555 98.338  189.733 1.00 102.19 ?  599  LYS   C CB    1 
ATOM   3437 C CG    . LYS   A 1 599  ? 191.750 97.489  190.126 1.00 109.48 ?  599  LYS   C CG    1 
ATOM   3438 C CD    . LYS   A 1 599  ? 192.063 97.626  191.605 1.00 114.23 ?  599  LYS   C CD    1 
ATOM   3439 C CE    . LYS   A 1 599  ? 193.238 96.746  192.007 1.00 121.85 ?  599  LYS   C CE    1 
ATOM   3440 N NZ    . LYS   A 1 599  ? 193.561 96.883  193.452 1.00 122.84 1  599  LYS   C NZ    1 
ATOM   3441 N N     . ILE   A 1 600  ? 188.705 100.137 187.896 1.00 93.82  ?  600  ILE   C N     1 
ATOM   3442 C CA    . ILE   A 1 600  ? 187.407 100.751 187.678 1.00 91.89  ?  600  ILE   C CA    1 
ATOM   3443 C C     . ILE   A 1 600  ? 186.856 100.335 186.330 1.00 90.18  ?  600  ILE   C C     1 
ATOM   3444 O O     . ILE   A 1 600  ? 185.683 99.990  186.226 1.00 85.29  ?  600  ILE   C O     1 
ATOM   3445 C CB    . ILE   A 1 600  ? 187.452 102.290 187.762 1.00 94.98  ?  600  ILE   C CB    1 
ATOM   3446 C CG1   . ILE   A 1 600  ? 187.773 102.730 189.202 1.00 98.26  ?  600  ILE   C CG1   1 
ATOM   3447 C CG2   . ILE   A 1 600  ? 186.118 102.873 187.309 1.00 92.35  ?  600  ILE   C CG2   1 
ATOM   3448 C CD1   . ILE   A 1 600  ? 188.028 104.224 189.351 1.00 101.39 ?  600  ILE   C CD1   1 
ATOM   3449 N N     . SER   A 1 601  ? 187.698 100.364 185.299 1.00 89.06  ?  601  SER   C N     1 
ATOM   3450 C CA    . SER   A 1 601  ? 187.254 100.019 183.958 1.00 87.67  ?  601  SER   C CA    1 
ATOM   3451 C C     . SER   A 1 601  ? 186.701 98.602  183.901 1.00 83.42  ?  601  SER   C C     1 
ATOM   3452 O O     . SER   A 1 601  ? 185.660 98.360  183.287 1.00 82.15  ?  601  SER   C O     1 
ATOM   3453 C CB    . SER   A 1 601  ? 188.397 100.176 182.980 1.00 87.47  ?  601  SER   C CB    1 
ATOM   3454 O OG    . SER   A 1 601  ? 187.987 99.863  181.682 1.00 83.52  ?  601  SER   C OG    1 
ATOM   3455 N N     . GLN   A 1 602  ? 187.378 97.668  184.568 1.00 86.36  ?  602  GLN   C N     1 
ATOM   3456 C CA    . GLN   A 1 602  ? 186.918 96.286  184.590 1.00 86.30  ?  602  GLN   C CA    1 
ATOM   3457 C C     . GLN   A 1 602  ? 185.553 96.177  185.262 1.00 83.31  ?  602  GLN   C C     1 
ATOM   3458 O O     . GLN   A 1 602  ? 184.670 95.464  184.779 1.00 85.31  ?  602  GLN   C O     1 
ATOM   3459 C CB    . GLN   A 1 602  ? 187.929 95.410  185.327 1.00 89.28  ?  602  GLN   C CB    1 
ATOM   3460 C CG    . GLN   A 1 602  ? 189.240 95.216  184.590 1.00 93.37  ?  602  GLN   C CG    1 
ATOM   3461 C CD    . GLN   A 1 602  ? 190.284 94.543  185.449 1.00 99.94  ?  602  GLN   C CD    1 
ATOM   3462 O OE1   . GLN   A 1 602  ? 190.158 94.493  186.676 1.00 104.20 ?  602  GLN   C OE1   1 
ATOM   3463 N NE2   . GLN   A 1 602  ? 191.326 94.022  184.814 1.00 101.88 ?  602  GLN   C NE2   1 
ATOM   3464 N N     . GLN   A 1 603  ? 185.365 96.912  186.354 1.00 83.13  ?  603  GLN   C N     1 
ATOM   3465 C CA    . GLN   A 1 603  ? 184.092 96.896  187.060 1.00 83.35  ?  603  GLN   C CA    1 
ATOM   3466 C C     . GLN   A 1 603  ? 182.988 97.503  186.206 1.00 79.44  ?  603  GLN   C C     1 
ATOM   3467 O O     . GLN   A 1 603  ? 181.872 96.981  186.161 1.00 78.55  ?  603  GLN   C O     1 
ATOM   3468 C CB    . GLN   A 1 603  ? 184.209 97.652  188.378 1.00 90.03  ?  603  GLN   C CB    1 
ATOM   3469 C CG    . GLN   A 1 603  ? 185.069 96.964  189.410 1.00 94.19  ?  603  GLN   C CG    1 
ATOM   3470 C CD    . GLN   A 1 603  ? 185.353 97.860  190.596 1.00 99.12  ?  603  GLN   C CD    1 
ATOM   3471 O OE1   . GLN   A 1 603  ? 185.032 99.052  190.567 1.00 94.76  ?  603  GLN   C OE1   1 
ATOM   3472 N NE2   . GLN   A 1 603  ? 185.955 97.299  191.638 1.00 99.56  ?  603  GLN   C NE2   1 
ATOM   3473 N N     . ILE   A 1 604  ? 183.312 98.580  185.495 1.00 78.23  ?  604  ILE   C N     1 
ATOM   3474 C CA    . ILE   A 1 604  ? 182.339 99.216  184.621 1.00 75.09  ?  604  ILE   C CA    1 
ATOM   3475 C C     . ILE   A 1 604  ? 181.934 98.252  183.520 1.00 75.31  ?  604  ILE   C C     1 
ATOM   3476 O O     . ILE   A 1 604  ? 180.749 98.109  183.221 1.00 71.78  ?  604  ILE   C O     1 
ATOM   3477 C CB    . ILE   A 1 604  ? 182.902 100.512 183.995 1.00 74.07  ?  604  ILE   C CB    1 
ATOM   3478 C CG1   . ILE   A 1 604  ? 183.177 101.585 185.088 1.00 78.13  ?  604  ILE   C CG1   1 
ATOM   3479 C CG2   . ILE   A 1 604  ? 181.942 101.044 182.937 1.00 68.48  ?  604  ILE   C CG2   1 
ATOM   3480 C CD1   . ILE   A 1 604  ? 181.975 102.076 185.820 1.00 76.45  ?  604  ILE   C CD1   1 
ATOM   3481 N N     . ARG   A 1 605  ? 182.909 97.566  182.933 1.00 75.66  ?  605  ARG   C N     1 
ATOM   3482 C CA    . ARG   A 1 605  ? 182.621 96.615  181.874 1.00 75.07  ?  605  ARG   C CA    1 
ATOM   3483 C C     . ARG   A 1 605  ? 181.584 95.592  182.316 1.00 71.54  ?  605  ARG   C C     1 
ATOM   3484 O O     . ARG   A 1 605  ? 180.621 95.320  181.598 1.00 69.49  ?  605  ARG   C O     1 
ATOM   3485 C CB    . ARG   A 1 605  ? 183.886 95.884  181.454 1.00 79.47  ?  605  ARG   C CB    1 
ATOM   3486 C CG    . ARG   A 1 605  ? 183.710 94.897  180.318 1.00 77.27  ?  605  ARG   C CG    1 
ATOM   3487 C CD    . ARG   A 1 605  ? 184.983 94.200  179.995 1.00 75.77  ?  605  ARG   C CD    1 
ATOM   3488 N NE    . ARG   A 1 605  ? 185.471 93.397  181.118 1.00 84.77  ?  605  ARG   C NE    1 
ATOM   3489 C CZ    . ARG   A 1 605  ? 185.022 92.163  181.450 1.00 86.77  ?  605  ARG   C CZ    1 
ATOM   3490 N NH1   . ARG   A 1 605  ? 184.071 91.586  180.746 1.00 85.14  1  605  ARG   C NH1   1 
ATOM   3491 N NH2   . ARG   A 1 605  ? 185.544 91.532  182.488 1.00 85.13  ?  605  ARG   C NH2   1 
ATOM   3492 N N     . LEU   A 1 606  ? 181.775 95.033  183.507 1.00 74.70  ?  606  LEU   C N     1 
ATOM   3493 C CA    . LEU   A 1 606  ? 180.853 94.026  184.008 1.00 73.97  ?  606  LEU   C CA    1 
ATOM   3494 C C     . LEU   A 1 606  ? 179.465 94.603  184.251 1.00 74.04  ?  606  LEU   C C     1 
ATOM   3495 O O     . LEU   A 1 606  ? 178.458 93.970  183.921 1.00 70.70  ?  606  LEU   C O     1 
ATOM   3496 C CB    . LEU   A 1 606  ? 181.395 93.427  185.309 1.00 76.31  ?  606  LEU   C CB    1 
ATOM   3497 C CG    . LEU   A 1 606  ? 182.674 92.577  185.181 1.00 81.44  ?  606  LEU   C CG    1 
ATOM   3498 C CD1   . LEU   A 1 606  ? 183.204 92.266  186.572 1.00 85.36  ?  606  LEU   C CD1   1 
ATOM   3499 C CD2   . LEU   A 1 606  ? 182.365 91.288  184.423 1.00 81.62  ?  606  LEU   C CD2   1 
ATOM   3500 N N     . GLU   A 1 607  ? 179.404 95.815  184.793 1.00 71.78  ?  607  GLU   C N     1 
ATOM   3501 C CA    . GLU   A 1 607  ? 178.117 96.444  185.056 1.00 71.17  ?  607  GLU   C CA    1 
ATOM   3502 C C     . GLU   A 1 607  ? 177.391 96.785  183.762 1.00 67.33  ?  607  GLU   C C     1 
ATOM   3503 O O     . GLU   A 1 607  ? 176.170 96.641  183.671 1.00 67.39  ?  607  GLU   C O     1 
ATOM   3504 C CB    . GLU   A 1 607  ? 178.294 97.706  185.900 1.00 74.63  ?  607  GLU   C CB    1 
ATOM   3505 C CG    . GLU   A 1 607  ? 178.729 97.447  187.339 1.00 82.46  ?  607  GLU   C CG    1 
ATOM   3506 C CD    . GLU   A 1 607  ? 177.744 96.611  188.108 1.00 87.60  ?  607  GLU   C CD    1 
ATOM   3507 O OE1   . GLU   A 1 607  ? 176.568 96.853  187.987 1.00 83.46  ?  607  GLU   C OE1   1 
ATOM   3508 O OE2   . GLU   A 1 607  ? 178.167 95.719  188.814 1.00 85.11  -1 607  GLU   C OE2   1 
ATOM   3509 N N     . LEU   A 1 608  ? 178.142 97.209  182.751 1.00 65.49  ?  608  LEU   C N     1 
ATOM   3510 C CA    . LEU   A 1 608  ? 177.542 97.542  181.470 1.00 64.90  ?  608  LEU   C CA    1 
ATOM   3511 C C     . LEU   A 1 608  ? 176.971 96.298  180.803 1.00 66.74  ?  608  LEU   C C     1 
ATOM   3512 O O     . LEU   A 1 608  ? 175.917 96.358  180.167 1.00 62.17  ?  608  LEU   C O     1 
ATOM   3513 C CB    . LEU   A 1 608  ? 178.570 98.204  180.546 1.00 61.71  ?  608  LEU   C CB    1 
ATOM   3514 C CG    . LEU   A 1 608  ? 179.072 99.615  180.955 1.00 63.21  ?  608  LEU   C CG    1 
ATOM   3515 C CD1   . LEU   A 1 608  ? 180.185 100.036 179.999 1.00 61.49  ?  608  LEU   C CD1   1 
ATOM   3516 C CD2   . LEU   A 1 608  ? 177.928 100.617 180.925 1.00 61.90  ?  608  LEU   C CD2   1 
ATOM   3517 N N     . LEU   A 1 609  ? 177.646 95.163  180.959 1.00 65.01  ?  609  LEU   C N     1 
ATOM   3518 C CA    . LEU   A 1 609  ? 177.159 93.930  180.357 1.00 60.66  ?  609  LEU   C CA    1 
ATOM   3519 C C     . LEU   A 1 609  ? 175.849 93.497  181.006 1.00 60.61  ?  609  LEU   C C     1 
ATOM   3520 O O     . LEU   A 1 609  ? 174.914 93.083  180.315 1.00 60.71  ?  609  LEU   C O     1 
ATOM   3521 C CB    . LEU   A 1 609  ? 178.202 92.816  180.493 1.00 63.28  ?  609  LEU   C CB    1 
ATOM   3522 C CG    . LEU   A 1 609  ? 177.862 91.461  179.826 1.00 66.53  ?  609  LEU   C CG    1 
ATOM   3523 C CD1   . LEU   A 1 609  ? 177.637 91.654  178.315 1.00 66.09  ?  609  LEU   C CD1   1 
ATOM   3524 C CD2   . LEU   A 1 609  ? 179.014 90.492  180.071 1.00 67.06  ?  609  LEU   C CD2   1 
ATOM   3525 N N     . LYS   A 1 610  ? 175.774 93.604  182.333 1.00 62.57  ?  610  LYS   C N     1 
ATOM   3526 C CA    . LYS   A 1 610  ? 174.547 93.262  183.045 1.00 64.19  ?  610  LYS   C CA    1 
ATOM   3527 C C     . LYS   A 1 610  ? 173.410 94.185  182.623 1.00 61.93  ?  610  LYS   C C     1 
ATOM   3528 O O     . LYS   A 1 610  ? 172.268 93.751  182.461 1.00 61.46  ?  610  LYS   C O     1 
ATOM   3529 C CB    . LYS   A 1 610  ? 174.760 93.345  184.556 1.00 67.59  ?  610  LYS   C CB    1 
ATOM   3530 C CG    . LYS   A 1 610  ? 175.629 92.232  185.129 1.00 70.19  ?  610  LYS   C CG    1 
ATOM   3531 C CD    . LYS   A 1 610  ? 175.633 92.250  186.654 1.00 77.10  ?  610  LYS   C CD    1 
ATOM   3532 C CE    . LYS   A 1 610  ? 176.473 93.398  187.198 1.00 78.72  ?  610  LYS   C CE    1 
ATOM   3533 N NZ    . LYS   A 1 610  ? 176.604 93.344  188.682 1.00 82.08  1  610  LYS   C NZ    1 
ATOM   3534 N N     . TRP   A 1 611  ? 173.735 95.459  182.424 1.00 59.41  ?  611  TRP   C N     1 
ATOM   3535 C CA    . TRP   A 1 611  ? 172.765 96.448  181.983 1.00 57.87  ?  611  TRP   C CA    1 
ATOM   3536 C C     . TRP   A 1 611  ? 172.176 96.052  180.639 1.00 59.19  ?  611  TRP   C C     1 
ATOM   3537 O O     . TRP   A 1 611  ? 170.958 96.082  180.457 1.00 60.70  ?  611  TRP   C O     1 
ATOM   3538 C CB    . TRP   A 1 611  ? 173.434 97.816  181.912 1.00 57.91  ?  611  TRP   C CB    1 
ATOM   3539 C CG    . TRP   A 1 611  ? 172.559 98.947  181.480 1.00 54.91  ?  611  TRP   C CG    1 
ATOM   3540 C CD1   . TRP   A 1 611  ? 171.652 99.610  182.242 1.00 58.95  ?  611  TRP   C CD1   1 
ATOM   3541 C CD2   . TRP   A 1 611  ? 172.538 99.588  180.187 1.00 49.67  ?  611  TRP   C CD2   1 
ATOM   3542 N NE1   . TRP   A 1 611  ? 171.070 100.614 181.517 1.00 57.80  ?  611  TRP   C NE1   1 
ATOM   3543 C CE2   . TRP   A 1 611  ? 171.604 100.620 180.260 1.00 51.25  ?  611  TRP   C CE2   1 
ATOM   3544 C CE3   . TRP   A 1 611  ? 173.243 99.387  179.003 1.00 53.27  ?  611  TRP   C CE3   1 
ATOM   3545 C CZ2   . TRP   A 1 611  ? 171.340 101.446 179.185 1.00 50.37  ?  611  TRP   C CZ2   1 
ATOM   3546 C CZ3   . TRP   A 1 611  ? 172.981 100.214 177.923 1.00 52.65  ?  611  TRP   C CZ3   1 
ATOM   3547 C CH2   . TRP   A 1 611  ? 172.057 101.222 178.014 1.00 51.31  ?  611  TRP   C CH2   1 
ATOM   3548 N N     . ILE   A 1 612  ? 173.034 95.630  179.712 1.00 58.90  ?  612  ILE   C N     1 
ATOM   3549 C CA    . ILE   A 1 612  ? 172.567 95.201  178.402 1.00 55.84  ?  612  ILE   C CA    1 
ATOM   3550 C C     . ILE   A 1 612  ? 171.610 94.028  178.524 1.00 59.21  ?  612  ILE   C C     1 
ATOM   3551 O O     . ILE   A 1 612  ? 170.560 94.015  177.887 1.00 59.42  ?  612  ILE   C O     1 
ATOM   3552 C CB    . ILE   A 1 612  ? 173.736 94.786  177.494 1.00 51.75  ?  612  ILE   C CB    1 
ATOM   3553 C CG1   . ILE   A 1 612  ? 174.576 96.003  177.138 1.00 56.73  ?  612  ILE   C CG1   1 
ATOM   3554 C CG2   . ILE   A 1 612  ? 173.199 94.104  176.233 1.00 51.61  ?  612  ILE   C CG2   1 
ATOM   3555 C CD1   . ILE   A 1 612  ? 175.894 95.660  176.517 1.00 58.92  ?  612  ILE   C CD1   1 
ATOM   3556 N N     . GLU   A 1 613  ? 171.969 93.038  179.336 1.00 60.68  ?  613  GLU   C N     1 
ATOM   3557 C CA    . GLU   A 1 613  ? 171.108 91.871  179.497 1.00 61.50  ?  613  GLU   C CA    1 
ATOM   3558 C C     . GLU   A 1 613  ? 169.701 92.267  179.920 1.00 60.83  ?  613  GLU   C C     1 
ATOM   3559 O O     . GLU   A 1 613  ? 168.714 91.775  179.368 1.00 62.67  ?  613  GLU   C O     1 
ATOM   3560 C CB    . GLU   A 1 613  ? 171.692 90.907  180.532 1.00 61.71  ?  613  GLU   C CB    1 
ATOM   3561 C CG    . GLU   A 1 613  ? 170.832 89.679  180.780 1.00 65.19  ?  613  GLU   C CG    1 
ATOM   3562 C CD    . GLU   A 1 613  ? 171.449 88.690  181.729 1.00 68.94  ?  613  GLU   C CD    1 
ATOM   3563 O OE1   . GLU   A 1 613  ? 172.511 88.954  182.236 1.00 66.37  ?  613  GLU   C OE1   1 
ATOM   3564 O OE2   . GLU   A 1 613  ? 170.849 87.661  181.948 1.00 70.23  -1 613  GLU   C OE2   1 
ATOM   3565 N N     . VAL   A 1 614  ? 169.606 93.161  180.895 1.00 58.82  ?  614  VAL   C N     1 
ATOM   3566 C CA    . VAL   A 1 614  ? 168.308 93.579  181.403 1.00 61.74  ?  614  VAL   C CA    1 
ATOM   3567 C C     . VAL   A 1 614  ? 167.504 94.343  180.360 1.00 63.58  ?  614  VAL   C C     1 
ATOM   3568 O O     . VAL   A 1 614  ? 166.306 94.107  180.197 1.00 67.58  ?  614  VAL   C O     1 
ATOM   3569 C CB    . VAL   A 1 614  ? 168.476 94.460  182.654 1.00 65.23  ?  614  VAL   C CB    1 
ATOM   3570 C CG1   . VAL   A 1 614  ? 167.126 95.048  183.075 1.00 61.84  ?  614  VAL   C CG1   1 
ATOM   3571 C CG2   . VAL   A 1 614  ? 169.066 93.626  183.778 1.00 66.85  ?  614  VAL   C CG2   1 
ATOM   3572 N N     . LYS   A 1 615  ? 168.157 95.274  179.674 1.00 60.44  ?  615  LYS   C N     1 
ATOM   3573 C CA    . LYS   A 1 615  ? 167.455 96.103  178.706 1.00 60.23  ?  615  LYS   C CA    1 
ATOM   3574 C C     . LYS   A 1 615  ? 167.105 95.316  177.448 1.00 62.00  ?  615  LYS   C C     1 
ATOM   3575 O O     . LYS   A 1 615  ? 166.082 95.578  176.817 1.00 64.07  ?  615  LYS   C O     1 
ATOM   3576 C CB    . LYS   A 1 615  ? 168.297 97.330  178.351 1.00 60.96  ?  615  LYS   C CB    1 
ATOM   3577 C CG    . LYS   A 1 615  ? 168.622 98.255  179.544 1.00 62.61  ?  615  LYS   C CG    1 
ATOM   3578 C CD    . LYS   A 1 615  ? 167.375 98.883  180.169 1.00 62.07  ?  615  LYS   C CD    1 
ATOM   3579 C CE    . LYS   A 1 615  ? 167.753 99.770  181.351 1.00 62.68  ?  615  LYS   C CE    1 
ATOM   3580 N NZ    . LYS   A 1 615  ? 166.558 100.324 182.048 1.00 66.33  1  615  LYS   C NZ    1 
ATOM   3581 N N     . ALA   A 1 616  ? 167.948 94.355  177.080 1.00 59.89  ?  616  ALA   C N     1 
ATOM   3582 C CA    . ALA   A 1 616  ? 167.686 93.531  175.908 1.00 62.05  ?  616  ALA   C CA    1 
ATOM   3583 C C     . ALA   A 1 616  ? 166.457 92.650  176.131 1.00 65.72  ?  616  ALA   C C     1 
ATOM   3584 O O     . ALA   A 1 616  ? 165.643 92.473  175.224 1.00 66.39  ?  616  ALA   C O     1 
ATOM   3585 C CB    . ALA   A 1 616  ? 168.900 92.672  175.579 1.00 63.19  ?  616  ALA   C CB    1 
ATOM   3586 N N     . LYS   A 1 617  ? 166.312 92.118  177.347 1.00 68.61  ?  617  LYS   C N     1 
ATOM   3587 C CA    . LYS   A 1 617  ? 165.156 91.288  177.687 1.00 74.53  ?  617  LYS   C CA    1 
ATOM   3588 C C     . LYS   A 1 617  ? 163.870 92.104  177.773 1.00 74.34  ?  617  LYS   C C     1 
ATOM   3589 O O     . LYS   A 1 617  ? 162.799 91.642  177.369 1.00 75.92  ?  617  LYS   C O     1 
ATOM   3590 C CB    . LYS   A 1 617  ? 165.385 90.554  179.009 1.00 74.63  ?  617  LYS   C CB    1 
ATOM   3591 C CG    . LYS   A 1 617  ? 166.401 89.420  178.942 1.00 77.42  ?  617  LYS   C CG    1 
ATOM   3592 C CD    . LYS   A 1 617  ? 166.587 88.766  180.308 1.00 77.25  ?  617  LYS   C CD    1 
ATOM   3593 C CE    . LYS   A 1 617  ? 167.641 87.664  180.260 1.00 77.18  ?  617  LYS   C CE    1 
ATOM   3594 N NZ    . LYS   A 1 617  ? 167.854 87.033  181.597 1.00 75.01  1  617  LYS   C NZ    1 
ATOM   3595 N N     . ALA   A 1 618  ? 163.969 93.320  178.296 1.00 74.11  ?  618  ALA   C N     1 
ATOM   3596 C CA    . ALA   A 1 618  ? 162.798 94.170  178.478 1.00 79.34  ?  618  ALA   C CA    1 
ATOM   3597 C C     . ALA   A 1 618  ? 162.387 94.798  177.155 1.00 79.23  ?  618  ALA   C C     1 
ATOM   3598 O O     . ALA   A 1 618  ? 162.556 96.000  176.935 1.00 84.12  ?  618  ALA   C O     1 
ATOM   3599 C CB    . ALA   A 1 618  ? 163.089 95.249  179.507 1.00 80.60  ?  618  ALA   C CB    1 
ATOM   3600 N N     . LYS   A 1 619  ? 161.834 93.975  176.277 1.00 79.37  ?  619  LYS   C N     1 
ATOM   3601 C CA    . LYS   A 1 619  ? 161.483 94.411  174.936 1.00 85.78  ?  619  LYS   C CA    1 
ATOM   3602 C C     . LYS   A 1 619  ? 160.166 95.176  174.915 1.00 88.58  ?  619  LYS   C C     1 
ATOM   3603 O O     . LYS   A 1 619  ? 159.111 94.619  174.614 1.00 88.81  ?  619  LYS   C O     1 
ATOM   3604 C CB    . LYS   A 1 619  ? 161.407 93.209  173.996 1.00 88.89  ?  619  LYS   C CB    1 
ATOM   3605 C CG    . LYS   A 1 619  ? 161.127 93.562  172.549 1.00 89.66  ?  619  LYS   C CG    1 
ATOM   3606 C CD    . LYS   A 1 619  ? 161.114 92.323  171.675 1.00 80.99  ?  619  LYS   C CD    1 
ATOM   3607 C CE    . LYS   A 1 619  ? 160.847 92.675  170.225 1.00 75.89  ?  619  LYS   C CE    1 
ATOM   3608 N NZ    . LYS   A 1 619  ? 159.473 93.216  170.025 1.00 75.50  1  619  LYS   C NZ    1 
ATOM   3609 N N     . LYS   A 1 620  ? 160.249 96.461  175.238 1.00 90.47  ?  620  LYS   C N     1 
ATOM   3610 C CA    . LYS   A 1 620  ? 159.088 97.344  175.296 1.00 89.30  ?  620  LYS   C CA    1 
ATOM   3611 C C     . LYS   A 1 620  ? 159.322 98.569  174.419 1.00 86.82  ?  620  LYS   C C     1 
ATOM   3612 O O     . LYS   A 1 620  ? 160.465 98.901  174.109 1.00 88.93  ?  620  LYS   C O     1 
ATOM   3613 C CB    . LYS   A 1 620  ? 158.805 97.767  176.741 1.00 88.25  ?  620  LYS   C CB    1 
ATOM   3614 C CG    . LYS   A 1 620  ? 158.532 96.610  177.709 1.00 89.15  ?  620  LYS   C CG    1 
ATOM   3615 C CD    . LYS   A 1 620  ? 157.208 95.919  177.402 1.00 95.22  ?  620  LYS   C CD    1 
ATOM   3616 C CE    . LYS   A 1 620  ? 156.900 94.826  178.416 1.00 98.62  ?  620  LYS   C CE    1 
ATOM   3617 N NZ    . LYS   A 1 620  ? 155.629 94.115  178.096 1.00 100.17 1  620  LYS   C NZ    1 
ATOM   3618 N N     . LEU   A 1 621  ? 158.248 99.244  174.018 1.00 89.79  ?  621  LEU   C N     1 
ATOM   3619 C CA    . LEU   A 1 621  ? 158.400 100.450 173.209 1.00 87.64  ?  621  LEU   C CA    1 
ATOM   3620 C C     . LEU   A 1 621  ? 158.636 101.664 174.094 1.00 82.55  ?  621  LEU   C C     1 
ATOM   3621 O O     . LEU   A 1 621  ? 157.811 102.002 174.942 1.00 82.46  ?  621  LEU   C O     1 
ATOM   3622 C CB    . LEU   A 1 621  ? 157.163 100.667 172.326 1.00 94.34  ?  621  LEU   C CB    1 
ATOM   3623 C CG    . LEU   A 1 621  ? 157.166 101.945 171.452 1.00 100.08 ?  621  LEU   C CG    1 
ATOM   3624 C CD1   . LEU   A 1 621  ? 158.298 101.870 170.425 1.00 94.87  ?  621  LEU   C CD1   1 
ATOM   3625 C CD2   . LEU   A 1 621  ? 155.815 102.075 170.757 1.00 103.30 ?  621  LEU   C CD2   1 
ATOM   3626 N N     . GLN   A 1 622  ? 159.792 102.289 173.907 1.00 79.01  ?  622  GLN   C N     1 
ATOM   3627 C CA    . GLN   A 1 622  ? 160.244 103.390 174.747 1.00 74.01  ?  622  GLN   C CA    1 
ATOM   3628 C C     . GLN   A 1 622  ? 161.509 104.017 174.173 1.00 70.99  ?  622  GLN   C C     1 
ATOM   3629 O O     . GLN   A 1 622  ? 162.195 103.387 173.371 1.00 72.85  ?  622  GLN   C O     1 
ATOM   3630 C CB    . GLN   A 1 622  ? 160.485 102.860 176.152 1.00 74.52  ?  622  GLN   C CB    1 
ATOM   3631 C CG    . GLN   A 1 622  ? 161.427 101.669 176.182 1.00 76.55  ?  622  GLN   C CG    1 
ATOM   3632 C CD    . GLN   A 1 622  ? 161.446 101.016 177.522 1.00 80.95  ?  622  GLN   C CD    1 
ATOM   3633 O OE1   . GLN   A 1 622  ? 161.014 101.625 178.505 1.00 83.60  ?  622  GLN   C OE1   1 
ATOM   3634 N NE2   . GLN   A 1 622  ? 161.942 99.786  177.594 1.00 79.88  ?  622  GLN   C NE2   1 
ATOM   3635 N N     . ILE   A 1 623  ? 161.835 105.240 174.596 1.00 64.58  ?  623  ILE   C N     1 
ATOM   3636 C CA    . ILE   A 1 623  ? 163.053 105.898 174.121 1.00 63.67  ?  623  ILE   C CA    1 
ATOM   3637 C C     . ILE   A 1 623  ? 164.343 105.288 174.664 1.00 57.00  ?  623  ILE   C C     1 
ATOM   3638 O O     . ILE   A 1 623  ? 165.376 105.326 173.997 1.00 51.79  ?  623  ILE   C O     1 
ATOM   3639 C CB    . ILE   A 1 623  ? 163.027 107.410 174.421 1.00 65.05  ?  623  ILE   C CB    1 
ATOM   3640 C CG1   . ILE   A 1 623  ? 164.092 108.147 173.580 1.00 58.97  ?  623  ILE   C CG1   1 
ATOM   3641 C CG2   . ILE   A 1 623  ? 163.258 107.679 175.914 1.00 63.61  ?  623  ILE   C CG2   1 
ATOM   3642 C CD1   . ILE   A 1 623  ? 163.855 108.080 172.062 1.00 56.67  ?  623  ILE   C CD1   1 
ATOM   3643 N N     . GLN   A 1 624  ? 164.300 104.748 175.878 1.00 55.15  ?  624  GLN   C N     1 
ATOM   3644 C CA    . GLN   A 1 624  ? 165.483 104.102 176.425 1.00 52.55  ?  624  GLN   C CA    1 
ATOM   3645 C C     . GLN   A 1 624  ? 165.767 102.923 175.482 1.00 48.74  ?  624  GLN   C C     1 
ATOM   3646 O O     . GLN   A 1 624  ? 164.981 102.714 174.563 1.00 54.48  ?  624  GLN   C O     1 
ATOM   3647 C CB    . GLN   A 1 624  ? 165.231 103.721 177.891 1.00 58.94  ?  624  GLN   C CB    1 
ATOM   3648 C CG    . GLN   A 1 624  ? 164.285 102.588 178.113 1.00 65.84  ?  624  GLN   C CG    1 
ATOM   3649 C CD    . GLN   A 1 624  ? 164.326 102.104 179.550 1.00 76.46  ?  624  GLN   C CD    1 
ATOM   3650 O OE1   . GLN   A 1 624  ? 165.416 101.924 180.107 1.00 69.45  ?  624  GLN   C OE1   1 
ATOM   3651 N NE2   . GLN   A 1 624  ? 163.167 101.896 180.160 1.00 81.71  ?  624  GLN   C NE2   1 
ATOM   3652 N N     . PRO   A 1 625  ? 166.826 102.121 175.667 1.00 44.74  ?  625  PRO   C N     1 
ATOM   3653 C CA    . PRO   A 1 625  ? 167.337 101.205 174.668 1.00 44.17  ?  625  PRO   C CA    1 
ATOM   3654 C C     . PRO   A 1 625  ? 166.219 100.380 174.048 1.00 49.02  ?  625  PRO   C C     1 
ATOM   3655 O O     . PRO   A 1 625  ? 165.440 99.743  174.758 1.00 54.45  ?  625  PRO   C O     1 
ATOM   3656 C CB    . PRO   A 1 625  ? 168.284 100.339 175.498 1.00 46.25  ?  625  PRO   C CB    1 
ATOM   3657 C CG    . PRO   A 1 625  ? 168.755 101.259 176.585 1.00 48.57  ?  625  PRO   C CG    1 
ATOM   3658 C CD    . PRO   A 1 625  ? 167.536 102.071 176.937 1.00 49.93  ?  625  PRO   C CD    1 
ATOM   3659 N N     . SER   A 1 626  ? 166.174 100.387 172.716 1.00 42.92  ?  626  SER   C N     1 
ATOM   3660 C CA    . SER   A 1 626  ? 165.141 99.719  171.934 1.00 44.59  ?  626  SER   C CA    1 
ATOM   3661 C C     . SER   A 1 626  ? 165.728 98.869  170.812 1.00 42.65  ?  626  SER   C C     1 
ATOM   3662 O O     . SER   A 1 626  ? 165.252 98.904  169.681 1.00 40.97  ?  626  SER   C O     1 
ATOM   3663 C CB    . SER   A 1 626  ? 164.205 100.752 171.339 1.00 42.77  ?  626  SER   C CB    1 
ATOM   3664 O OG    . SER   A 1 626  ? 164.915 101.670 170.551 1.00 39.31  ?  626  SER   C OG    1 
ATOM   3665 N N     . GLN   A 1 627  ? 166.777 98.117  171.132 1.00 40.06  ?  627  GLN   C N     1 
ATOM   3666 C CA    . GLN   A 1 627  ? 167.449 97.205  170.202 1.00 36.66  ?  627  GLN   C CA    1 
ATOM   3667 C C     . GLN   A 1 627  ? 168.224 97.893  169.073 1.00 39.14  ?  627  GLN   C C     1 
ATOM   3668 O O     . GLN   A 1 627  ? 168.735 97.220  168.182 1.00 38.70  ?  627  GLN   C O     1 
ATOM   3669 C CB    . GLN   A 1 627  ? 166.430 96.234  169.580 1.00 36.16  ?  627  GLN   C CB    1 
ATOM   3670 C CG    . GLN   A 1 627  ? 165.717 95.342  170.582 1.00 40.26  ?  627  GLN   C CG    1 
ATOM   3671 C CD    . GLN   A 1 627  ? 166.652 94.322  171.169 1.00 44.84  ?  627  GLN   C CD    1 
ATOM   3672 O OE1   . GLN   A 1 627  ? 167.603 93.929  170.497 1.00 39.62  ?  627  GLN   C OE1   1 
ATOM   3673 N NE2   . GLN   A 1 627  ? 166.401 93.880  172.393 1.00 52.82  ?  627  GLN   C NE2   1 
ATOM   3674 N N     . LEU   A 1 628  ? 168.186 99.221  168.914 1.00 37.66  ?  628  LEU   C N     1 
ATOM   3675 C CA    . LEU   A 1 628  ? 169.082 99.836  167.872 1.00 33.85  ?  628  LEU   C CA    1 
ATOM   3676 C C     . LEU   A 1 628  ? 170.162 100.558 168.652 1.00 34.74  ?  628  LEU   C C     1 
ATOM   3677 O O     . LEU   A 1 628  ? 171.302 100.523 168.231 1.00 35.17  ?  628  LEU   C O     1 
ATOM   3678 C CB    . LEU   A 1 628  ? 168.363 100.797 166.921 1.00 28.21  ?  628  LEU   C CB    1 
ATOM   3679 C CG    . LEU   A 1 628  ? 169.225 101.604 165.967 1.00 24.40  ?  628  LEU   C CG    1 
ATOM   3680 C CD1   . LEU   A 1 628  ? 169.990 100.680 165.048 1.00 28.35  ?  628  LEU   C CD1   1 
ATOM   3681 C CD2   . LEU   A 1 628  ? 168.357 102.547 165.163 1.00 24.17  ?  628  LEU   C CD2   1 
ATOM   3682 N N     . GLU   A 1 629  ? 169.800 101.123 169.800 1.00 34.26  ?  629  GLU   C N     1 
ATOM   3683 C CA    . GLU   A 1 629  ? 170.786 101.921 170.546 1.00 32.23  ?  629  GLU   C CA    1 
ATOM   3684 C C     . GLU   A 1 629  ? 171.610 100.978 171.372 1.00 34.98  ?  629  GLU   C C     1 
ATOM   3685 O O     . GLU   A 1 629  ? 172.771 101.282 171.553 1.00 38.63  ?  629  GLU   C O     1 
ATOM   3686 C CB    . GLU   A 1 629  ? 170.185 102.897 171.532 1.00 30.26  ?  629  GLU   C CB    1 
ATOM   3687 C CG    . GLU   A 1 629  ? 170.443 104.333 171.199 1.00 30.37  ?  629  GLU   C CG    1 
ATOM   3688 C CD    . GLU   A 1 629  ? 169.177 104.899 170.608 1.00 31.46  ?  629  GLU   C CD    1 
ATOM   3689 O OE1   . GLU   A 1 629  ? 168.522 105.703 171.269 1.00 35.58  ?  629  GLU   C OE1   1 
ATOM   3690 O OE2   . GLU   A 1 629  ? 168.874 104.563 169.464 1.00 24.92  -1 629  GLU   C OE2   1 
ATOM   3691 N N     . LEU   A 1 630  ? 171.059 99.859  171.808 1.00 34.09  ?  630  LEU   C N     1 
ATOM   3692 C CA    . LEU   A 1 630  ? 171.958 98.964  172.554 1.00 33.79  ?  630  LEU   C CA    1 
ATOM   3693 C C     . LEU   A 1 630  ? 173.027 98.530  171.568 1.00 38.11  ?  630  LEU   C C     1 
ATOM   3694 O O     . LEU   A 1 630  ? 174.100 98.133  172.000 1.00 41.08  ?  630  LEU   C O     1 
ATOM   3695 C CB    . LEU   A 1 630  ? 171.191 97.775  173.092 1.00 33.68  ?  630  LEU   C CB    1 
ATOM   3696 C CG    . LEU   A 1 630  ? 171.778 97.137  174.337 1.00 37.29  ?  630  LEU   C CG    1 
ATOM   3697 C CD1   . LEU   A 1 630  ? 172.512 98.181  175.142 1.00 45.97  ?  630  LEU   C CD1   1 
ATOM   3698 C CD2   . LEU   A 1 630  ? 170.674 96.519  175.168 1.00 51.53  ?  630  LEU   C CD2   1 
ATOM   3699 N N     . PHE   A 1 631  ? 172.754 98.672  170.277 1.00 37.31  ?  631  PHE   C N     1 
ATOM   3700 C CA    . PHE   A 1 631  ? 173.723 98.242  169.252 1.00 38.96  ?  631  PHE   C CA    1 
ATOM   3701 C C     . PHE   A 1 631  ? 174.798 99.306  169.162 1.00 39.78  ?  631  PHE   C C     1 
ATOM   3702 O O     . PHE   A 1 631  ? 175.948 98.943  169.292 1.00 41.62  ?  631  PHE   C O     1 
ATOM   3703 C CB    . PHE   A 1 631  ? 173.037 98.047  167.904 1.00 38.66  ?  631  PHE   C CB    1 
ATOM   3704 C CG    . PHE   A 1 631  ? 172.379 96.718  167.678 1.00 37.37  ?  631  PHE   C CG    1 
ATOM   3705 C CD1   . PHE   A 1 631  ? 172.642 95.643  168.503 1.00 41.93  ?  631  PHE   C CD1   1 
ATOM   3706 C CD2   . PHE   A 1 631  ? 171.506 96.550  166.625 1.00 34.91  ?  631  PHE   C CD2   1 
ATOM   3707 C CE1   . PHE   A 1 631  ? 172.034 94.422  168.287 1.00 38.41  ?  631  PHE   C CE1   1 
ATOM   3708 C CE2   . PHE   A 1 631  ? 170.899 95.330  166.409 1.00 36.11  ?  631  PHE   C CE2   1 
ATOM   3709 C CZ    . PHE   A 1 631  ? 171.163 94.273  167.242 1.00 37.70  ?  631  PHE   C CZ    1 
ATOM   3710 N N     . TYR   A 1 632  ? 174.430 100.560 168.905 1.00 36.85  ?  632  TYR   C N     1 
ATOM   3711 C CA    . TYR   A 1 632  ? 175.490 101.564 168.710 1.00 34.61  ?  632  TYR   C CA    1 
ATOM   3712 C C     . TYR   A 1 632  ? 176.335 101.512 169.959 1.00 37.49  ?  632  TYR   C C     1 
ATOM   3713 O O     . TYR   A 1 632  ? 177.546 101.475 169.834 1.00 41.38  ?  632  TYR   C O     1 
ATOM   3714 C CB    . TYR   A 1 632  ? 174.982 102.990 168.683 1.00 34.93  ?  632  TYR   C CB    1 
ATOM   3715 C CG    . TYR   A 1 632  ? 174.391 103.618 167.460 1.00 30.60  ?  632  TYR   C CG    1 
ATOM   3716 C CD1   . TYR   A 1 632  ? 173.034 103.835 167.389 1.00 33.89  ?  632  TYR   C CD1   1 
ATOM   3717 C CD2   . TYR   A 1 632  ? 175.187 104.189 166.497 1.00 31.54  ?  632  TYR   C CD2   1 
ATOM   3718 C CE1   . TYR   A 1 632  ? 172.464 104.499 166.326 1.00 33.15  ?  632  TYR   C CE1   1 
ATOM   3719 C CE2   . TYR   A 1 632  ? 174.635 104.849 165.419 1.00 33.57  ?  632  TYR   C CE2   1 
ATOM   3720 C CZ    . TYR   A 1 632  ? 173.270 105.008 165.339 1.00 31.99  ?  632  TYR   C CZ    1 
ATOM   3721 O OH    . TYR   A 1 632  ? 172.702 105.668 164.300 1.00 39.34  ?  632  TYR   C OH    1 
ATOM   3722 N N     . CYS   A 1 633  ? 175.705 101.440 171.130 1.00 37.06  ?  633  CYS   C N     1 
ATOM   3723 C CA    . CYS   A 1 633  ? 176.488 101.507 172.390 1.00 39.52  ?  633  CYS   C CA    1 
ATOM   3724 C C     . CYS   A 1 633  ? 177.341 100.268 172.500 1.00 43.70  ?  633  CYS   C C     1 
ATOM   3725 O O     . CYS   A 1 633  ? 177.988 100.128 173.530 1.00 47.19  ?  633  CYS   C O     1 
ATOM   3726 C CB    . CYS   A 1 633  ? 175.670 101.562 173.668 1.00 38.75  ?  633  CYS   C CB    1 
ATOM   3727 S SG    . CYS   A 1 633  ? 174.568 102.992 173.762 1.00 45.46  ?  633  CYS   C SG    1 
ATOM   3728 N N     . LEU   A 1 634  ? 177.271 99.376  171.521 1.00 42.77  ?  634  LEU   C N     1 
ATOM   3729 C CA    . LEU   A 1 634  ? 178.172 98.212  171.519 1.00 44.04  ?  634  LEU   C CA    1 
ATOM   3730 C C     . LEU   A 1 634  ? 179.242 98.524  170.482 1.00 45.27  ?  634  LEU   C C     1 
ATOM   3731 O O     . LEU   A 1 634  ? 180.414 98.333  170.805 1.00 46.48  ?  634  LEU   C O     1 
ATOM   3732 C CB    . LEU   A 1 634  ? 177.363 96.946  171.227 1.00 40.80  ?  634  LEU   C CB    1 
ATOM   3733 C CG    . LEU   A 1 634  ? 176.919 96.202  172.478 1.00 39.29  ?  634  LEU   C CG    1 
ATOM   3734 C CD1   . LEU   A 1 634  ? 175.714 95.337  172.193 1.00 50.15  ?  634  LEU   C CD1   1 
ATOM   3735 C CD2   . LEU   A 1 634  ? 178.054 95.362  173.015 1.00 48.58  ?  634  LEU   C CD2   1 
ATOM   3736 N N     . TYR   A 1 635  ? 178.839 99.032  169.318 1.00 42.46  ?  635  TYR   C N     1 
ATOM   3737 C CA    . TYR   A 1 635  ? 179.813 99.288  168.228 1.00 44.19  ?  635  TYR   C CA    1 
ATOM   3738 C C     . TYR   A 1 635  ? 180.957 100.043 168.849 1.00 45.96  ?  635  TYR   C C     1 
ATOM   3739 O O     . TYR   A 1 635  ? 182.115 99.705  168.593 1.00 48.75  ?  635  TYR   C O     1 
ATOM   3740 C CB    . TYR   A 1 635  ? 179.231 100.148 167.108 1.00 42.88  ?  635  TYR   C CB    1 
ATOM   3741 C CG    . TYR   A 1 635  ? 180.153 100.483 165.975 1.00 38.10  ?  635  TYR   C CG    1 
ATOM   3742 C CD1   . TYR   A 1 635  ? 180.613 99.497  165.133 1.00 43.44  ?  635  TYR   C CD1   1 
ATOM   3743 C CD2   . TYR   A 1 635  ? 180.533 101.785 165.724 1.00 41.26  ?  635  TYR   C CD2   1 
ATOM   3744 C CE1   . TYR   A 1 635  ? 181.465 99.786  164.086 1.00 47.20  ?  635  TYR   C CE1   1 
ATOM   3745 C CE2   . TYR   A 1 635  ? 181.379 102.096 164.678 1.00 43.48  ?  635  TYR   C CE2   1 
ATOM   3746 C CZ    . TYR   A 1 635  ? 181.846 101.091 163.855 1.00 46.02  ?  635  TYR   C CZ    1 
ATOM   3747 O OH    . TYR   A 1 635  ? 182.677 101.367 162.813 1.00 47.89  ?  635  TYR   C OH    1 
ATOM   3748 N N     . GLU   A 1 636  ? 180.620 100.985 169.713 1.00 43.83  ?  636  GLU   C N     1 
ATOM   3749 C CA    . GLU   A 1 636  ? 181.662 101.853 170.238 1.00 42.77  ?  636  GLU   C CA    1 
ATOM   3750 C C     . GLU   A 1 636  ? 182.752 101.076 170.971 1.00 46.35  ?  636  GLU   C C     1 
ATOM   3751 O O     . GLU   A 1 636  ? 183.870 101.570 171.127 1.00 49.57  ?  636  GLU   C O     1 
ATOM   3752 C CB    . GLU   A 1 636  ? 181.043 102.897 171.162 1.00 38.39  ?  636  GLU   C CB    1 
ATOM   3753 C CG    . GLU   A 1 636  ? 180.222 103.949 170.438 1.00 39.28  ?  636  GLU   C CG    1 
ATOM   3754 C CD    . GLU   A 1 636  ? 181.071 104.874 169.646 1.00 45.11  ?  636  GLU   C CD    1 
ATOM   3755 O OE1   . GLU   A 1 636  ? 181.976 105.433 170.220 1.00 49.76  ?  636  GLU   C OE1   1 
ATOM   3756 O OE2   . GLU   A 1 636  ? 180.840 105.029 168.464 1.00 47.46  -1 636  GLU   C OE2   1 
ATOM   3757 N N     . MET   A 1 637  ? 182.425 99.882  171.455 1.00 45.44  ?  637  MET   C N     1 
ATOM   3758 C CA    . MET   A 1 637  ? 183.396 99.050  172.146 1.00 48.89  ?  637  MET   C CA    1 
ATOM   3759 C C     . MET   A 1 637  ? 183.815 97.885  171.260 1.00 51.02  ?  637  MET   C C     1 
ATOM   3760 O O     . MET   A 1 637  ? 183.248 96.794  171.345 1.00 54.42  ?  637  MET   C O     1 
ATOM   3761 C CB    . MET   A 1 637  ? 182.829 98.538  173.466 1.00 49.39  ?  637  MET   C CB    1 
ATOM   3762 C CG    . MET   A 1 637  ? 183.812 97.708  174.276 1.00 55.42  ?  637  MET   C CG    1 
ATOM   3763 S SD    . MET   A 1 637  ? 183.200 97.281  175.909 1.00 67.67  ?  637  MET   C SD    1 
ATOM   3764 C CE    . MET   A 1 637  ? 184.555 96.269  176.490 1.00 71.73  ?  637  MET   C CE    1 
ATOM   3765 N N     . GLN   A 1 638  ? 184.814 98.104  170.412 1.00 54.12  ?  638  GLN   C N     1 
ATOM   3766 C CA    . GLN   A 1 638  ? 185.216 97.091  169.440 1.00 55.27  ?  638  GLN   C CA    1 
ATOM   3767 C C     . GLN   A 1 638  ? 186.023 95.971  170.079 1.00 59.44  ?  638  GLN   C C     1 
ATOM   3768 O O     . GLN   A 1 638  ? 187.214 95.818  169.817 1.00 65.44  ?  638  GLN   C O     1 
ATOM   3769 C CB    . GLN   A 1 638  ? 186.037 97.724  168.310 1.00 57.90  ?  638  GLN   C CB    1 
ATOM   3770 C CG    . GLN   A 1 638  ? 185.262 98.671  167.407 1.00 53.97  ?  638  GLN   C CG    1 
ATOM   3771 C CD    . GLN   A 1 638  ? 184.359 97.917  166.451 1.00 55.98  ?  638  GLN   C CD    1 
ATOM   3772 O OE1   . GLN   A 1 638  ? 184.841 97.150  165.610 1.00 58.93  ?  638  GLN   C OE1   1 
ATOM   3773 N NE2   . GLN   A 1 638  ? 183.061 98.116  166.568 1.00 51.67  ?  638  GLN   C NE2   1 
ATOM   3774 N N     . GLU   A 1 639  ? 185.351 95.185  170.910 1.00 58.23  ?  639  GLU   C N     1 
ATOM   3775 C CA    . GLU   A 1 639  ? 185.955 94.039  171.573 1.00 62.34  ?  639  GLU   C CA    1 
ATOM   3776 C C     . GLU   A 1 639  ? 185.112 92.806  171.304 1.00 65.72  ?  639  GLU   C C     1 
ATOM   3777 O O     . GLU   A 1 639  ? 183.938 92.753  171.672 1.00 64.30  ?  639  GLU   C O     1 
ATOM   3778 C CB    . GLU   A 1 639  ? 186.071 94.288  173.077 1.00 69.06  ?  639  GLU   C CB    1 
ATOM   3779 C CG    . GLU   A 1 639  ? 186.701 93.146  173.857 1.00 73.14  ?  639  GLU   C CG    1 
ATOM   3780 C CD    . GLU   A 1 639  ? 186.805 93.437  175.321 1.00 83.22  ?  639  GLU   C CD    1 
ATOM   3781 O OE1   . GLU   A 1 639  ? 187.463 94.382  175.674 1.00 90.30  ?  639  GLU   C OE1   1 
ATOM   3782 O OE2   . GLU   A 1 639  ? 186.228 92.710  176.091 1.00 77.68  -1 639  GLU   C OE2   1 
ATOM   3783 N N     . GLU   A 1 640  ? 185.702 91.815  170.653 1.00 68.74  ?  640  GLU   C N     1 
ATOM   3784 C CA    . GLU   A 1 640  ? 184.948 90.645  170.230 1.00 69.17  ?  640  GLU   C CA    1 
ATOM   3785 C C     . GLU   A 1 640  ? 184.326 89.889  171.391 1.00 67.09  ?  640  GLU   C C     1 
ATOM   3786 O O     . GLU   A 1 640  ? 183.190 89.431  171.296 1.00 66.24  ?  640  GLU   C O     1 
ATOM   3787 C CB    . GLU   A 1 640  ? 185.849 89.702  169.433 1.00 71.52  ?  640  GLU   C CB    1 
ATOM   3788 C CG    . GLU   A 1 640  ? 186.295 90.249  168.084 1.00 76.64  ?  640  GLU   C CG    1 
ATOM   3789 C CD    . GLU   A 1 640  ? 187.431 91.231  168.192 1.00 84.89  ?  640  GLU   C CD    1 
ATOM   3790 O OE1   . GLU   A 1 640  ? 187.892 91.460  169.289 1.00 80.26  ?  640  GLU   C OE1   1 
ATOM   3791 O OE2   . GLU   A 1 640  ? 187.837 91.754  167.182 1.00 84.96  -1 640  GLU   C OE2   1 
ATOM   3792 N N     . ASP   A 1 641  ? 185.053 89.771  172.496 1.00 67.01  ?  641  ASP   C N     1 
ATOM   3793 C CA    . ASP   A 1 641  ? 184.538 88.999  173.618 1.00 69.92  ?  641  ASP   C CA    1 
ATOM   3794 C C     . ASP   A 1 641  ? 183.330 89.689  174.239 1.00 67.77  ?  641  ASP   C C     1 
ATOM   3795 O O     . ASP   A 1 641  ? 182.310 89.051  174.505 1.00 66.59  ?  641  ASP   C O     1 
ATOM   3796 C CB    . ASP   A 1 641  ? 185.628 88.797  174.677 1.00 71.87  ?  641  ASP   C CB    1 
ATOM   3797 C CG    . ASP   A 1 641  ? 185.256 87.759  175.742 1.00 76.42  ?  641  ASP   C CG    1 
ATOM   3798 O OD1   . ASP   A 1 641  ? 185.192 86.600  175.411 1.00 75.73  ?  641  ASP   C OD1   1 
ATOM   3799 O OD2   . ASP   A 1 641  ? 185.044 88.136  176.872 1.00 74.66  -1 641  ASP   C OD2   1 
ATOM   3800 N N     . PHE   A 1 642  ? 183.434 90.996  174.451 1.00 66.19  ?  642  PHE   C N     1 
ATOM   3801 C CA    . PHE   A 1 642  ? 182.348 91.740  175.070 1.00 64.80  ?  642  PHE   C CA    1 
ATOM   3802 C C     . PHE   A 1 642  ? 181.120 91.749  174.183 1.00 60.48  ?  642  PHE   C C     1 
ATOM   3803 O O     . PHE   A 1 642  ? 180.005 91.507  174.651 1.00 61.99  ?  642  PHE   C O     1 
ATOM   3804 C CB    . PHE   A 1 642  ? 182.760 93.175  175.367 1.00 64.80  ?  642  PHE   C CB    1 
ATOM   3805 C CG    . PHE   A 1 642  ? 181.723 93.945  176.134 1.00 60.52  ?  642  PHE   C CG    1 
ATOM   3806 C CD1   . PHE   A 1 642  ? 181.634 93.816  177.506 1.00 65.51  ?  642  PHE   C CD1   1 
ATOM   3807 C CD2   . PHE   A 1 642  ? 180.839 94.800  175.495 1.00 58.44  ?  642  PHE   C CD2   1 
ATOM   3808 C CE1   . PHE   A 1 642  ? 180.696 94.521  178.221 1.00 68.95  ?  642  PHE   C CE1   1 
ATOM   3809 C CE2   . PHE   A 1 642  ? 179.898 95.504  176.219 1.00 56.80  ?  642  PHE   C CE2   1 
ATOM   3810 C CZ    . PHE   A 1 642  ? 179.830 95.363  177.581 1.00 63.47  ?  642  PHE   C CZ    1 
ATOM   3811 N N     . VAL   A 1 643  ? 181.315 92.031  172.899 1.00 55.52  ?  643  VAL   C N     1 
ATOM   3812 C CA    . VAL   A 1 643  ? 180.181 92.111  172.001 1.00 52.62  ?  643  VAL   C CA    1 
ATOM   3813 C C     . VAL   A 1 643  ? 179.492 90.764  171.880 1.00 57.07  ?  643  VAL   C C     1 
ATOM   3814 O O     . VAL   A 1 643  ? 178.267 90.697  171.936 1.00 55.29  ?  643  VAL   C O     1 
ATOM   3815 C CB    . VAL   A 1 643  ? 180.607 92.631  170.614 1.00 52.55  ?  643  VAL   C CB    1 
ATOM   3816 C CG1   . VAL   A 1 643  ? 179.445 92.520  169.620 1.00 56.39  ?  643  VAL   C CG1   1 
ATOM   3817 C CG2   . VAL   A 1 643  ? 181.046 94.089  170.742 1.00 52.94  ?  643  VAL   C CG2   1 
ATOM   3818 N N     . GLN   A 1 644  ? 180.257 89.685  171.735 1.00 59.05  ?  644  GLN   C N     1 
ATOM   3819 C CA    . GLN   A 1 644  ? 179.633 88.375  171.612 1.00 59.86  ?  644  GLN   C CA    1 
ATOM   3820 C C     . GLN   A 1 644  ? 178.844 88.017  172.864 1.00 57.32  ?  644  GLN   C C     1 
ATOM   3821 O O     . GLN   A 1 644  ? 177.728 87.505  172.768 1.00 56.89  ?  644  GLN   C O     1 
ATOM   3822 C CB    . GLN   A 1 644  ? 180.678 87.298  171.331 1.00 61.89  ?  644  GLN   C CB    1 
ATOM   3823 C CG    . GLN   A 1 644  ? 181.276 87.354  169.938 1.00 61.41  ?  644  GLN   C CG    1 
ATOM   3824 C CD    . GLN   A 1 644  ? 182.415 86.366  169.776 1.00 68.88  ?  644  GLN   C CD    1 
ATOM   3825 O OE1   . GLN   A 1 644  ? 182.770 85.662  170.726 1.00 68.89  ?  644  GLN   C OE1   1 
ATOM   3826 N NE2   . GLN   A 1 644  ? 182.994 86.307  168.585 1.00 66.96  ?  644  GLN   C NE2   1 
ATOM   3827 N N     . ARG   A 1 645  ? 179.397 88.318  174.036 1.00 56.48  ?  645  ARG   C N     1 
ATOM   3828 C CA    . ARG   A 1 645  ? 178.687 88.030  175.272 1.00 56.73  ?  645  ARG   C CA    1 
ATOM   3829 C C     . ARG   A 1 645  ? 177.381 88.796  175.320 1.00 54.48  ?  645  ARG   C C     1 
ATOM   3830 O O     . ARG   A 1 645  ? 176.350 88.261  175.724 1.00 57.80  ?  645  ARG   C O     1 
ATOM   3831 C CB    . ARG   A 1 645  ? 179.528 88.401  176.481 1.00 62.87  ?  645  ARG   C CB    1 
ATOM   3832 C CG    . ARG   A 1 645  ? 180.684 87.469  176.765 1.00 66.38  ?  645  ARG   C CG    1 
ATOM   3833 C CD    . ARG   A 1 645  ? 181.508 87.951  177.902 1.00 69.48  ?  645  ARG   C CD    1 
ATOM   3834 N NE    . ARG   A 1 645  ? 182.667 87.104  178.126 1.00 73.97  ?  645  ARG   C NE    1 
ATOM   3835 C CZ    . ARG   A 1 645  ? 182.662 85.954  178.830 1.00 79.78  ?  645  ARG   C CZ    1 
ATOM   3836 N NH1   . ARG   A 1 645  ? 181.548 85.513  179.382 1.00 77.69  1  645  ARG   C NH1   1 
ATOM   3837 N NH2   . ARG   A 1 645  ? 183.782 85.267  178.963 1.00 78.59  ?  645  ARG   C NH2   1 
ATOM   3838 N N     . ALA   A 1 646  ? 177.418 90.049  174.888 1.00 51.87  ?  646  ALA   C N     1 
ATOM   3839 C CA    . ALA   A 1 646  ? 176.219 90.861  174.863 1.00 52.30  ?  646  ALA   C CA    1 
ATOM   3840 C C     . ALA   A 1 646  ? 175.204 90.301  173.881 1.00 54.03  ?  646  ALA   C C     1 
ATOM   3841 O O     . ALA   A 1 646  ? 174.017 90.226  174.187 1.00 56.03  ?  646  ALA   C O     1 
ATOM   3842 C CB    . ALA   A 1 646  ? 176.569 92.286  174.498 1.00 56.92  ?  646  ALA   C CB    1 
ATOM   3843 N N     . MET   A 1 647  ? 175.675 89.867  172.713 1.00 52.95  ?  647  MET   C N     1 
ATOM   3844 C CA    . MET   A 1 647  ? 174.785 89.383  171.661 1.00 53.59  ?  647  MET   C CA    1 
ATOM   3845 C C     . MET   A 1 647  ? 174.053 88.103  172.038 1.00 53.56  ?  647  MET   C C     1 
ATOM   3846 O O     . MET   A 1 647  ? 172.978 87.819  171.511 1.00 51.55  ?  647  MET   C O     1 
ATOM   3847 C CB    . MET   A 1 647  ? 175.533 89.222  170.349 1.00 52.05  ?  647  MET   C CB    1 
ATOM   3848 C CG    . MET   A 1 647  ? 175.945 90.546  169.732 1.00 53.21  ?  647  MET   C CG    1 
ATOM   3849 S SD    . MET   A 1 647  ? 174.559 91.690  169.572 1.00 48.65  ?  647  MET   C SD    1 
ATOM   3850 C CE    . MET   A 1 647  ? 175.390 93.091  168.896 1.00 48.97  ?  647  MET   C CE    1 
ATOM   3851 N N     . ASP   A 1 648  ? 174.596 87.351  172.985 1.00 54.49  ?  648  ASP   C N     1 
ATOM   3852 C CA    . ASP   A 1 648  ? 173.928 86.144  173.457 1.00 52.43  ?  648  ASP   C CA    1 
ATOM   3853 C C     . ASP   A 1 648  ? 172.593 86.458  174.136 1.00 50.29  ?  648  ASP   C C     1 
ATOM   3854 O O     . ASP   A 1 648  ? 171.785 85.559  174.371 1.00 52.40  ?  648  ASP   C O     1 
ATOM   3855 C CB    . ASP   A 1 648  ? 174.830 85.365  174.412 1.00 57.35  ?  648  ASP   C CB    1 
ATOM   3856 C CG    . ASP   A 1 648  ? 175.967 84.650  173.689 1.00 63.62  ?  648  ASP   C CG    1 
ATOM   3857 O OD1   . ASP   A 1 648  ? 175.895 84.514  172.485 1.00 62.92  ?  648  ASP   C OD1   1 
ATOM   3858 O OD2   . ASP   A 1 648  ? 176.892 84.233  174.345 1.00 65.04  -1 648  ASP   C OD2   1 
ATOM   3859 N N     . TYR   A 1 649  ? 172.349 87.733  174.433 1.00 49.78  ?  649  TYR   C N     1 
ATOM   3860 C CA    . TYR   A 1 649  ? 171.098 88.141  175.062 1.00 49.82  ?  649  TYR   C CA    1 
ATOM   3861 C C     . TYR   A 1 649  ? 170.119 88.712  174.043 1.00 49.73  ?  649  TYR   C C     1 
ATOM   3862 O O     . TYR   A 1 649  ? 169.079 89.262  174.411 1.00 53.80  ?  649  TYR   C O     1 
ATOM   3863 C CB    . TYR   A 1 649  ? 171.361 89.181  176.148 1.00 51.35  ?  649  TYR   C CB    1 
ATOM   3864 C CG    . TYR   A 1 649  ? 172.294 88.703  177.215 1.00 53.68  ?  649  TYR   C CG    1 
ATOM   3865 C CD1   . TYR   A 1 649  ? 173.519 89.319  177.375 1.00 57.54  ?  649  TYR   C CD1   1 
ATOM   3866 C CD2   . TYR   A 1 649  ? 171.940 87.641  178.027 1.00 57.68  ?  649  TYR   C CD2   1 
ATOM   3867 C CE1   . TYR   A 1 649  ? 174.391 88.878  178.343 1.00 58.75  ?  649  TYR   C CE1   1 
ATOM   3868 C CE2   . TYR   A 1 649  ? 172.811 87.200  178.996 1.00 59.41  ?  649  TYR   C CE2   1 
ATOM   3869 C CZ    . TYR   A 1 649  ? 174.032 87.815  179.156 1.00 60.71  ?  649  TYR   C CZ    1 
ATOM   3870 O OH    . TYR   A 1 649  ? 174.901 87.369  180.122 1.00 63.05  ?  649  TYR   C OH    1 
ATOM   3871 N N     . PHE   A 1 650  ? 170.436 88.548  172.761 1.00 44.80  ?  650  PHE   C N     1 
ATOM   3872 C CA    . PHE   A 1 650  ? 169.605 89.054  171.675 1.00 44.18  ?  650  PHE   C CA    1 
ATOM   3873 C C     . PHE   A 1 650  ? 169.131 87.957  170.719 1.00 43.78  ?  650  PHE   C C     1 
ATOM   3874 O O     . PHE   A 1 650  ? 169.640 87.874  169.606 1.00 45.34  ?  650  PHE   C O     1 
ATOM   3875 C CB    . PHE   A 1 650  ? 170.391 90.069  170.835 1.00 46.04  ?  650  PHE   C CB    1 
ATOM   3876 C CG    . PHE   A 1 650  ? 170.793 91.331  171.525 1.00 46.98  ?  650  PHE   C CG    1 
ATOM   3877 C CD1   . PHE   A 1 650  ? 171.778 91.336  172.478 1.00 51.80  ?  650  PHE   C CD1   1 
ATOM   3878 C CD2   . PHE   A 1 650  ? 170.210 92.528  171.178 1.00 43.79  ?  650  PHE   C CD2   1 
ATOM   3879 C CE1   . PHE   A 1 650  ? 172.173 92.502  173.082 1.00 56.79  ?  650  PHE   C CE1   1 
ATOM   3880 C CE2   . PHE   A 1 650  ? 170.601 93.703  171.772 1.00 45.36  ?  650  PHE   C CE2   1 
ATOM   3881 C CZ    . PHE   A 1 650  ? 171.588 93.686  172.729 1.00 54.39  ?  650  PHE   C CZ    1 
ATOM   3882 N N     . PRO   A 1 651  ? 168.173 87.106  171.109 1.00 41.10  ?  651  PRO   C N     1 
ATOM   3883 C CA    . PRO   A 1 651  ? 167.610 86.042  170.297 1.00 37.22  ?  651  PRO   C CA    1 
ATOM   3884 C C     . PRO   A 1 651  ? 166.786 86.599  169.138 1.00 36.56  ?  651  PRO   C C     1 
ATOM   3885 O O     . PRO   A 1 651  ? 166.561 85.920  168.132 1.00 40.71  ?  651  PRO   C O     1 
ATOM   3886 C CB    . PRO   A 1 651  ? 166.739 85.282  171.305 1.00 38.92  ?  651  PRO   C CB    1 
ATOM   3887 C CG    . PRO   A 1 651  ? 166.398 86.306  172.367 1.00 45.96  ?  651  PRO   C CG    1 
ATOM   3888 C CD    . PRO   A 1 651  ? 167.621 87.195  172.462 1.00 46.83  ?  651  PRO   C CD    1 
ATOM   3889 N N     . LYS   A 1 652  ? 166.344 87.843  169.284 1.00 32.80  ?  652  LYS   C N     1 
ATOM   3890 C CA    . LYS   A 1 652  ? 165.546 88.495  168.259 1.00 30.69  ?  652  LYS   C CA    1 
ATOM   3891 C C     . LYS   A 1 652  ? 166.033 89.920  168.044 1.00 32.85  ?  652  LYS   C C     1 
ATOM   3892 O O     . LYS   A 1 652  ? 166.355 90.623  169.002 1.00 41.29  ?  652  LYS   C O     1 
ATOM   3893 C CB    . LYS   A 1 652  ? 164.072 88.509  168.664 1.00 34.16  ?  652  LYS   C CB    1 
ATOM   3894 C CG    . LYS   A 1 652  ? 163.455 87.133  168.874 1.00 41.87  ?  652  LYS   C CG    1 
ATOM   3895 C CD    . LYS   A 1 652  ? 161.969 87.247  169.173 1.00 50.08  ?  652  LYS   C CD    1 
ATOM   3896 C CE    . LYS   A 1 652  ? 161.331 85.885  169.391 1.00 59.12  ?  652  LYS   C CE    1 
ATOM   3897 N NZ    . LYS   A 1 652  ? 159.885 86.003  169.725 1.00 57.48  1  652  LYS   C NZ    1 
ATOM   3898 N N     . ILE   A 1 653  ? 166.057 90.351  166.790 1.00 28.06  ?  653  ILE   C N     1 
ATOM   3899 C CA    . ILE   A 1 653  ? 166.411 91.725  166.464 1.00 25.14  ?  653  ILE   C CA    1 
ATOM   3900 C C     . ILE   A 1 653  ? 165.321 92.387  165.639 1.00 26.56  ?  653  ILE   C C     1 
ATOM   3901 O O     . ILE   A 1 653  ? 165.042 91.958  164.521 1.00 30.76  ?  653  ILE   C O     1 
ATOM   3902 C CB    . ILE   A 1 653  ? 167.742 91.779  165.691 1.00 25.15  ?  653  ILE   C CB    1 
ATOM   3903 C CG1   . ILE   A 1 653  ? 168.871 91.193  166.546 1.00 30.01  ?  653  ILE   C CG1   1 
ATOM   3904 C CG2   . ILE   A 1 653  ? 168.053 93.216  165.252 1.00 29.58  ?  653  ILE   C CG2   1 
ATOM   3905 C CD1   . ILE   A 1 653  ? 170.197 91.061  165.810 1.00 34.36  ?  653  ILE   C CD1   1 
ATOM   3906 N N     . GLU   A 1 654  ? 164.725 93.446  166.172 1.00 28.69  ?  654  GLU   C N     1 
ATOM   3907 C CA    . GLU   A 1 654  ? 163.691 94.182  165.451 1.00 28.57  ?  654  GLU   C CA    1 
ATOM   3908 C C     . GLU   A 1 654  ? 164.079 95.647  165.353 1.00 28.89  ?  654  GLU   C C     1 
ATOM   3909 O O     . GLU   A 1 654  ? 163.928 96.398  166.316 1.00 34.12  ?  654  GLU   C O     1 
ATOM   3910 C CB    . GLU   A 1 654  ? 162.333 94.034  166.144 1.00 38.40  ?  654  GLU   C CB    1 
ATOM   3911 C CG    . GLU   A 1 654  ? 161.802 92.601  166.186 1.00 47.73  ?  654  GLU   C CG    1 
ATOM   3912 C CD    . GLU   A 1 654  ? 160.452 92.482  166.853 1.00 61.98  ?  654  GLU   C CD    1 
ATOM   3913 O OE1   . GLU   A 1 654  ? 159.926 93.483  167.289 1.00 61.17  ?  654  GLU   C OE1   1 
ATOM   3914 O OE2   . GLU   A 1 654  ? 159.948 91.384  166.936 1.00 58.59  -1 654  GLU   C OE2   1 
ATOM   3915 N N     . ILE   A 1 655  ? 164.634 96.041  164.214 1.00 26.24  ?  655  ILE   C N     1 
ATOM   3916 C CA    . ILE   A 1 655  ? 165.181 97.388  164.091 1.00 24.99  ?  655  ILE   C CA    1 
ATOM   3917 C C     . ILE   A 1 655  ? 164.717 98.132  162.847 1.00 28.06  ?  655  ILE   C C     1 
ATOM   3918 O O     . ILE   A 1 655  ? 164.301 97.526  161.859 1.00 33.46  ?  655  ILE   C O     1 
ATOM   3919 C CB    . ILE   A 1 655  ? 166.720 97.340  164.126 1.00 26.33  ?  655  ILE   C CB    1 
ATOM   3920 C CG1   . ILE   A 1 655  ? 167.256 96.508  162.942 1.00 23.81  ?  655  ILE   C CG1   1 
ATOM   3921 C CG2   . ILE   A 1 655  ? 167.176 96.770  165.458 1.00 37.66  ?  655  ILE   C CG2   1 
ATOM   3922 C CD1   . ILE   A 1 655  ? 168.761 96.540  162.795 1.00 26.75  ?  655  ILE   C CD1   1 
ATOM   3923 N N     . ASN   A 1 656  ? 164.839 99.454  162.901 1.00 28.08  ?  656  ASN   C N     1 
ATOM   3924 C CA    . ASN   A 1 656  ? 164.547 100.335 161.778 1.00 29.28  ?  656  ASN   C CA    1 
ATOM   3925 C C     . ASN   A 1 656  ? 165.785 101.135 161.415 1.00 34.11  ?  656  ASN   C C     1 
ATOM   3926 O O     . ASN   A 1 656  ? 166.324 101.865 162.245 1.00 39.75  ?  656  ASN   C O     1 
ATOM   3927 C CB    . ASN   A 1 656  ? 163.406 101.272 162.103 1.00 33.05  ?  656  ASN   C CB    1 
ATOM   3928 C CG    . ASN   A 1 656  ? 162.121 100.569 162.315 1.00 39.64  ?  656  ASN   C CG    1 
ATOM   3929 O OD1   . ASN   A 1 656  ? 161.632 100.477 163.446 1.00 44.89  ?  656  ASN   C OD1   1 
ATOM   3930 N ND2   . ASN   A 1 656  ? 161.549 100.066 161.255 1.00 41.42  ?  656  ASN   C ND2   1 
ATOM   3931 N N     . LEU   A 1 657  ? 166.248 100.977 160.188 1.00 31.76  ?  657  LEU   C N     1 
ATOM   3932 C CA    . LEU   A 1 657  ? 167.452 101.651 159.729 1.00 29.10  ?  657  LEU   C CA    1 
ATOM   3933 C C     . LEU   A 1 657  ? 167.101 102.925 158.980 1.00 35.78  ?  657  LEU   C C     1 
ATOM   3934 O O     . LEU   A 1 657  ? 166.387 102.884 157.976 1.00 42.72  ?  657  LEU   C O     1 
ATOM   3935 C CB    . LEU   A 1 657  ? 168.242 100.716 158.817 1.00 27.76  ?  657  LEU   C CB    1 
ATOM   3936 C CG    . LEU   A 1 657  ? 168.616 99.365  159.419 1.00 32.75  ?  657  LEU   C CG    1 
ATOM   3937 C CD1   . LEU   A 1 657  ? 169.194 98.475  158.338 1.00 41.23  ?  657  LEU   C CD1   1 
ATOM   3938 C CD2   . LEU   A 1 657  ? 169.623 99.572  160.524 1.00 34.73  ?  657  LEU   C CD2   1 
ATOM   3939 N N     . SER   A 1 658  ? 167.580 104.061 159.483 1.00 36.26  ?  658  SER   C N     1 
ATOM   3940 C CA    . SER   A 1 658  ? 167.250 105.355 158.904 1.00 36.41  ?  658  SER   C CA    1 
ATOM   3941 C C     . SER   A 1 658  ? 168.336 105.846 157.962 1.00 37.43  ?  658  SER   C C     1 
ATOM   3942 O O     . SER   A 1 658  ? 168.056 106.287 156.850 1.00 46.19  ?  658  SER   C O     1 
ATOM   3943 C CB    . SER   A 1 658  ? 167.027 106.368 160.008 1.00 40.56  ?  658  SER   C CB    1 
ATOM   3944 O OG    . SER   A 1 658  ? 166.728 107.631 159.485 1.00 46.95  ?  658  SER   C OG    1 
ATOM   3945 N N     . THR   A 1 659  ? 169.578 105.785 158.421 1.00 35.81  ?  659  THR   C N     1 
ATOM   3946 C CA    . THR   A 1 659  ? 170.696 106.296 157.637 1.00 35.30  ?  659  THR   C CA    1 
ATOM   3947 C C     . THR   A 1 659  ? 171.869 105.338 157.536 1.00 37.52  ?  659  THR   C C     1 
ATOM   3948 O O     . THR   A 1 659  ? 171.899 104.290 158.181 1.00 41.76  ?  659  THR   C O     1 
ATOM   3949 C CB    . THR   A 1 659  ? 171.187 107.629 158.200 1.00 40.96  ?  659  THR   C CB    1 
ATOM   3950 O OG1   . THR   A 1 659  ? 172.196 108.163 157.328 1.00 47.07  ?  659  THR   C OG1   1 
ATOM   3951 C CG2   . THR   A 1 659  ? 171.746 107.439 159.592 1.00 44.56  ?  659  THR   C CG2   1 
ATOM   3952 N N     . ARG   A 1 660  ? 172.861 105.727 156.745 1.00 37.43  ?  660  ARG   C N     1 
ATOM   3953 C CA    . ARG   A 1 660  ? 174.043 104.904 156.519 1.00 39.45  ?  660  ARG   C CA    1 
ATOM   3954 C C     . ARG   A 1 660  ? 174.713 104.512 157.827 1.00 39.49  ?  660  ARG   C C     1 
ATOM   3955 O O     . ARG   A 1 660  ? 175.260 103.416 157.947 1.00 44.20  ?  660  ARG   C O     1 
ATOM   3956 C CB    . ARG   A 1 660  ? 175.039 105.624 155.629 1.00 43.06  ?  660  ARG   C CB    1 
ATOM   3957 C CG    . ARG   A 1 660  ? 176.220 104.778 155.191 1.00 47.64  ?  660  ARG   C CG    1 
ATOM   3958 C CD    . ARG   A 1 660  ? 177.102 105.514 154.259 1.00 54.92  ?  660  ARG   C CD    1 
ATOM   3959 N NE    . ARG   A 1 660  ? 176.438 105.802 152.999 1.00 61.29  ?  660  ARG   C NE    1 
ATOM   3960 C CZ    . ARG   A 1 660  ? 176.316 104.932 151.977 1.00 75.04  ?  660  ARG   C CZ    1 
ATOM   3961 N NH1   . ARG   A 1 660  ? 176.811 103.716 152.079 1.00 73.40  1  660  ARG   C NH1   1 
ATOM   3962 N NH2   . ARG   A 1 660  ? 175.695 105.302 150.870 1.00 74.36  ?  660  ARG   C NH2   1 
ATOM   3963 N N     . MET   A 1 661  ? 174.665 105.410 158.801 1.00 37.79  ?  661  MET   C N     1 
ATOM   3964 C CA    . MET   A 1 661  ? 175.256 105.166 160.107 1.00 39.59  ?  661  MET   C CA    1 
ATOM   3965 C C     . MET   A 1 661  ? 174.589 103.997 160.818 1.00 41.39  ?  661  MET   C C     1 
ATOM   3966 O O     . MET   A 1 661  ? 175.236 103.290 161.593 1.00 43.38  ?  661  MET   C O     1 
ATOM   3967 C CB    . MET   A 1 661  ? 175.140 106.418 160.963 1.00 37.96  ?  661  MET   C CB    1 
ATOM   3968 C CG    . MET   A 1 661  ? 175.867 106.368 162.287 1.00 34.16  ?  661  MET   C CG    1 
ATOM   3969 S SD    . MET   A 1 661  ? 177.631 106.356 162.113 1.00 38.43  ?  661  MET   C SD    1 
ATOM   3970 C CE    . MET   A 1 661  ? 178.126 105.759 163.732 1.00 34.65  ?  661  MET   C CE    1 
ATOM   3971 N N     . ASP   A 1 662  ? 173.305 103.775 160.551 1.00 37.01  ?  662  ASP   C N     1 
ATOM   3972 C CA    . ASP   A 1 662  ? 172.594 102.695 161.206 1.00 35.93  ?  662  ASP   C CA    1 
ATOM   3973 C C     . ASP   A 1 662  ? 172.949 101.394 160.529 1.00 39.29  ?  662  ASP   C C     1 
ATOM   3974 O O     . ASP   A 1 662  ? 173.044 100.353 161.172 1.00 39.77  ?  662  ASP   C O     1 
ATOM   3975 C CB    . ASP   A 1 662  ? 171.081 102.884 161.123 1.00 38.35  ?  662  ASP   C CB    1 
ATOM   3976 C CG    . ASP   A 1 662  ? 170.561 104.076 161.861 1.00 38.97  ?  662  ASP   C CG    1 
ATOM   3977 O OD1   . ASP   A 1 662  ? 170.869 104.230 163.022 1.00 38.67  ?  662  ASP   C OD1   1 
ATOM   3978 O OD2   . ASP   A 1 662  ? 169.829 104.836 161.256 1.00 40.60  -1 662  ASP   C OD2   1 
ATOM   3979 N N     . HIS   A 1 663  ? 173.158 101.463 159.218 1.00 38.89  ?  663  HIS   C N     1 
ATOM   3980 C CA    . HIS   A 1 663  ? 173.530 100.278 158.460 1.00 37.15  ?  663  HIS   C CA    1 
ATOM   3981 C C     . HIS   A 1 663  ? 174.917 99.820  158.876 1.00 39.42  ?  663  HIS   C C     1 
ATOM   3982 O O     . HIS   A 1 663  ? 175.166 98.623  159.020 1.00 42.29  ?  663  HIS   C O     1 
ATOM   3983 C CB    . HIS   A 1 663  ? 173.505 100.553 156.953 1.00 35.35  ?  663  HIS   C CB    1 
ATOM   3984 C CG    . HIS   A 1 663  ? 172.137 100.594 156.353 1.00 37.93  ?  663  HIS   C CG    1 
ATOM   3985 N ND1   . HIS   A 1 663  ? 171.752 99.757  155.330 1.00 45.68  ?  663  HIS   C ND1   1 
ATOM   3986 C CD2   . HIS   A 1 663  ? 171.066 101.367 156.627 1.00 40.92  ?  663  HIS   C CD2   1 
ATOM   3987 C CE1   . HIS   A 1 663  ? 170.501 100.017 155.001 1.00 45.92  ?  663  HIS   C CE1   1 
ATOM   3988 N NE2   . HIS   A 1 663  ? 170.062 100.988 155.773 1.00 40.68  ?  663  HIS   C NE2   1 
ATOM   3989 N N     . MET   A 1 664  ? 175.820 100.772 159.092 1.00 39.21  ?  664  MET   C N     1 
ATOM   3990 C CA    . MET   A 1 664  ? 177.174 100.441 159.511 1.00 40.39  ?  664  MET   C CA    1 
ATOM   3991 C C     . MET   A 1 664  ? 177.178 99.751  160.869 1.00 43.09  ?  664  MET   C C     1 
ATOM   3992 O O     . MET   A 1 664  ? 177.845 98.731  161.054 1.00 45.85  ?  664  MET   C O     1 
ATOM   3993 C CB    . MET   A 1 664  ? 178.040 101.693 159.549 1.00 41.31  ?  664  MET   C CB    1 
ATOM   3994 C CG    . MET   A 1 664  ? 179.483 101.442 159.982 1.00 44.37  ?  664  MET   C CG    1 
ATOM   3995 S SD    . MET   A 1 664  ? 180.478 102.939 159.995 1.00 55.20  ?  664  MET   C SD    1 
ATOM   3996 C CE    . MET   A 1 664  ? 179.885 103.730 161.478 1.00 48.03  ?  664  MET   C CE    1 
ATOM   3997 N N     . VAL   A 1 665  ? 176.431 100.310 161.817 1.00 40.06  ?  665  VAL   C N     1 
ATOM   3998 C CA    . VAL   A 1 665  ? 176.353 99.739  163.152 1.00 39.53  ?  665  VAL   C CA    1 
ATOM   3999 C C     . VAL   A 1 665  ? 175.620 98.404  163.159 1.00 41.47  ?  665  VAL   C C     1 
ATOM   4000 O O     . VAL   A 1 665  ? 176.072 97.444  163.782 1.00 43.27  ?  665  VAL   C O     1 
ATOM   4001 C CB    . VAL   A 1 665  ? 175.667 100.726 164.109 1.00 40.22  ?  665  VAL   C CB    1 
ATOM   4002 C CG1   . VAL   A 1 665  ? 175.374 100.061 165.449 1.00 43.82  ?  665  VAL   C CG1   1 
ATOM   4003 C CG2   . VAL   A 1 665  ? 176.578 101.924 164.311 1.00 46.33  ?  665  VAL   C CG2   1 
ATOM   4004 N N     . SER   A 1 666  ? 174.491 98.347  162.459 1.00 39.43  ?  666  SER   C N     1 
ATOM   4005 C CA    . SER   A 1 666  ? 173.704 97.126  162.394 1.00 37.45  ?  666  SER   C CA    1 
ATOM   4006 C C     . SER   A 1 666  ? 174.508 96.004  161.771 1.00 39.54  ?  666  SER   C C     1 
ATOM   4007 O O     . SER   A 1 666  ? 174.493 94.874  162.263 1.00 43.14  ?  666  SER   C O     1 
ATOM   4008 C CB    . SER   A 1 666  ? 172.441 97.366  161.599 1.00 39.08  ?  666  SER   C CB    1 
ATOM   4009 O OG    . SER   A 1 666  ? 171.669 96.205  161.520 1.00 40.45  ?  666  SER   C OG    1 
ATOM   4010 N N     . SER   A 1 667  ? 175.238 96.310  160.700 1.00 39.59  ?  667  SER   C N     1 
ATOM   4011 C CA    . SER   A 1 667  ? 176.056 95.317  160.027 1.00 41.06  ?  667  SER   C CA    1 
ATOM   4012 C C     . SER   A 1 667  ? 177.076 94.717  160.982 1.00 42.35  ?  667  SER   C C     1 
ATOM   4013 O O     . SER   A 1 667  ? 177.189 93.497  161.092 1.00 46.44  ?  667  SER   C O     1 
ATOM   4014 C CB    . SER   A 1 667  ? 176.759 95.945  158.843 1.00 42.72  ?  667  SER   C CB    1 
ATOM   4015 O OG    . SER   A 1 667  ? 177.617 95.035  158.225 1.00 46.40  ?  667  SER   C OG    1 
ATOM   4016 N N     . PHE   A 1 668  ? 177.781 95.571  161.715 1.00 41.49  ?  668  PHE   C N     1 
ATOM   4017 C CA    . PHE   A 1 668  ? 178.755 95.086  162.683 1.00 44.46  ?  668  PHE   C CA    1 
ATOM   4018 C C     . PHE   A 1 668  ? 178.114 94.170  163.706 1.00 45.75  ?  668  PHE   C C     1 
ATOM   4019 O O     . PHE   A 1 668  ? 178.623 93.083  164.000 1.00 49.51  ?  668  PHE   C O     1 
ATOM   4020 C CB    . PHE   A 1 668  ? 179.404 96.253  163.419 1.00 45.79  ?  668  PHE   C CB    1 
ATOM   4021 C CG    . PHE   A 1 668  ? 180.254 95.823  164.573 1.00 43.64  ?  668  PHE   C CG    1 
ATOM   4022 C CD1   . PHE   A 1 668  ? 181.538 95.367  164.376 1.00 44.63  ?  668  PHE   C CD1   1 
ATOM   4023 C CD2   . PHE   A 1 668  ? 179.757 95.870  165.866 1.00 46.03  ?  668  PHE   C CD2   1 
ATOM   4024 C CE1   . PHE   A 1 668  ? 182.313 94.968  165.444 1.00 48.98  ?  668  PHE   C CE1   1 
ATOM   4025 C CE2   . PHE   A 1 668  ? 180.526 95.473  166.932 1.00 51.27  ?  668  PHE   C CE2   1 
ATOM   4026 C CZ    . PHE   A 1 668  ? 181.808 95.020  166.722 1.00 52.04  ?  668  PHE   C CZ    1 
ATOM   4027 N N     . CYS   A 1 669  ? 177.014 94.624  164.284 1.00 42.46  ?  669  CYS   C N     1 
ATOM   4028 C CA    . CYS   A 1 669  ? 176.367 93.883  165.343 1.00 46.51  ?  669  CYS   C CA    1 
ATOM   4029 C C     . CYS   A 1 669  ? 175.820 92.540  164.886 1.00 47.54  ?  669  CYS   C C     1 
ATOM   4030 O O     . CYS   A 1 669  ? 176.070 91.514  165.516 1.00 48.59  ?  669  CYS   C O     1 
ATOM   4031 C CB    . CYS   A 1 669  ? 175.253 94.724  165.940 1.00 46.26  ?  669  CYS   C CB    1 
ATOM   4032 S SG    . CYS   A 1 669  ? 175.871 96.071  166.949 1.00 55.82  ?  669  CYS   C SG    1 
ATOM   4033 N N     . ILE   A 1 670  ? 175.100 92.533  163.771 1.00 42.65  ?  670  ILE   C N     1 
ATOM   4034 C CA    . ILE   A 1 670  ? 174.517 91.300  163.267 1.00 35.22  ?  670  ILE   C CA    1 
ATOM   4035 C C     . ILE   A 1 670  ? 175.601 90.318  162.844 1.00 40.42  ?  670  ILE   C C     1 
ATOM   4036 O O     . ILE   A 1 670  ? 175.483 89.118  163.091 1.00 43.38  ?  670  ILE   C O     1 
ATOM   4037 C CB    . ILE   A 1 670  ? 173.520 91.581  162.130 1.00 33.53  ?  670  ILE   C CB    1 
ATOM   4038 C CG1   . ILE   A 1 670  ? 172.284 92.297  162.723 1.00 32.85  ?  670  ILE   C CG1   1 
ATOM   4039 C CG2   . ILE   A 1 670  ? 173.113 90.275  161.448 1.00 40.45  ?  670  ILE   C CG2   1 
ATOM   4040 C CD1   . ILE   A 1 670  ? 171.358 92.913  161.697 1.00 34.34  ?  670  ILE   C CD1   1 
ATOM   4041 N N     . GLU   A 1 671  ? 176.656 90.811  162.205 1.00 44.25  ?  671  GLU   C N     1 
ATOM   4042 C CA    . GLU   A 1 671  ? 177.750 89.947  161.770 1.00 48.64  ?  671  GLU   C CA    1 
ATOM   4043 C C     . GLU   A 1 671  ? 178.356 89.182  162.939 1.00 48.67  ?  671  GLU   C C     1 
ATOM   4044 O O     . GLU   A 1 671  ? 178.771 88.032  162.788 1.00 50.09  ?  671  GLU   C O     1 
ATOM   4045 C CB    . GLU   A 1 671  ? 178.843 90.752  161.068 1.00 49.87  ?  671  GLU   C CB    1 
ATOM   4046 C CG    . GLU   A 1 671  ? 179.950 89.896  160.454 1.00 53.22  ?  671  GLU   C CG    1 
ATOM   4047 C CD    . GLU   A 1 671  ? 180.957 90.690  159.663 1.00 63.68  ?  671  GLU   C CD    1 
ATOM   4048 O OE1   . GLU   A 1 671  ? 180.839 91.889  159.608 1.00 59.67  ?  671  GLU   C OE1   1 
ATOM   4049 O OE2   . GLU   A 1 671  ? 181.846 90.090  159.108 1.00 67.16  -1 671  GLU   C OE2   1 
ATOM   4050 N N     . ASN   A 1 672  ? 178.405 89.815  164.106 1.00 46.21  ?  672  ASN   C N     1 
ATOM   4051 C CA    . ASN   A 1 672  ? 179.003 89.202  165.283 1.00 46.96  ?  672  ASN   C CA    1 
ATOM   4052 C C     . ASN   A 1 672  ? 177.996 88.441  166.139 1.00 50.08  ?  672  ASN   C C     1 
ATOM   4053 O O     . ASN   A 1 672  ? 178.318 88.022  167.251 1.00 54.25  ?  672  ASN   C O     1 
ATOM   4054 C CB    . ASN   A 1 672  ? 179.697 90.261  166.114 1.00 47.67  ?  672  ASN   C CB    1 
ATOM   4055 C CG    . ASN   A 1 672  ? 180.957 90.743  165.471 1.00 53.38  ?  672  ASN   C CG    1 
ATOM   4056 O OD1   . ASN   A 1 672  ? 182.008 90.104  165.595 1.00 55.76  ?  672  ASN   C OD1   1 
ATOM   4057 N ND2   . ASN   A 1 672  ? 180.881 91.843  164.775 1.00 52.80  ?  672  ASN   C ND2   1 
ATOM   4058 N N     . CYS   A 1 673  ? 176.785 88.253  165.629 1.00 49.00  ?  673  CYS   C N     1 
ATOM   4059 C CA    . CYS   A 1 673  ? 175.774 87.509  166.364 1.00 49.91  ?  673  CYS   C CA    1 
ATOM   4060 C C     . CYS   A 1 673  ? 175.802 86.021  166.043 1.00 49.98  ?  673  CYS   C C     1 
ATOM   4061 O O     . CYS   A 1 673  ? 175.932 85.623  164.887 1.00 51.62  ?  673  CYS   C O     1 
ATOM   4062 C CB    . CYS   A 1 673  ? 174.383 88.037  166.060 1.00 50.36  ?  673  CYS   C CB    1 
ATOM   4063 S SG    . CYS   A 1 673  ? 174.026 89.663  166.735 1.00 61.24  ?  673  CYS   C SG    1 
ATOM   4064 N N     . HIS   A 1 674  ? 175.635 85.196  167.072 1.00 48.40  ?  674  HIS   C N     1 
ATOM   4065 C CA    . HIS   A 1 674  ? 175.606 83.751  166.881 1.00 48.12  ?  674  HIS   C CA    1 
ATOM   4066 C C     . HIS   A 1 674  ? 174.279 83.109  167.283 1.00 45.65  ?  674  HIS   C C     1 
ATOM   4067 O O     . HIS   A 1 674  ? 173.997 81.974  166.901 1.00 47.59  ?  674  HIS   C O     1 
ATOM   4068 C CB    . HIS   A 1 674  ? 176.743 83.098  167.666 1.00 49.61  ?  674  HIS   C CB    1 
ATOM   4069 C CG    . HIS   A 1 674  ? 178.098 83.519  167.208 1.00 56.42  ?  674  HIS   C CG    1 
ATOM   4070 N ND1   . HIS   A 1 674  ? 178.656 83.067  166.034 1.00 59.97  ?  674  HIS   C ND1   1 
ATOM   4071 C CD2   . HIS   A 1 674  ? 179.008 84.357  167.759 1.00 61.13  ?  674  HIS   C CD2   1 
ATOM   4072 C CE1   . HIS   A 1 674  ? 179.852 83.604  165.883 1.00 66.10  ?  674  HIS   C CE1   1 
ATOM   4073 N NE2   . HIS   A 1 674  ? 180.091 84.391  166.914 1.00 63.79  ?  674  HIS   C NE2   1 
ATOM   4074 N N     . ARG   A 1 675  ? 173.474 83.809  168.076 1.00 43.28  ?  675  ARG   C N     1 
ATOM   4075 C CA    . ARG   A 1 675  ? 172.251 83.215  168.607 1.00 41.75  ?  675  ARG   C CA    1 
ATOM   4076 C C     . ARG   A 1 675  ? 170.980 83.966  168.227 1.00 40.49  ?  675  ARG   C C     1 
ATOM   4077 O O     . ARG   A 1 675  ? 169.967 83.857  168.916 1.00 42.54  ?  675  ARG   C O     1 
ATOM   4078 C CB    . ARG   A 1 675  ? 172.333 83.087  170.120 1.00 51.12  ?  675  ARG   C CB    1 
ATOM   4079 C CG    . ARG   A 1 675  ? 173.313 82.024  170.618 1.00 56.70  ?  675  ARG   C CG    1 
ATOM   4080 C CD    . ARG   A 1 675  ? 173.342 81.942  172.108 1.00 65.97  ?  675  ARG   C CD    1 
ATOM   4081 N NE    . ARG   A 1 675  ? 174.056 80.752  172.574 1.00 73.81  ?  675  ARG   C NE    1 
ATOM   4082 C CZ    . ARG   A 1 675  ? 175.398 80.639  172.718 1.00 76.36  ?  675  ARG   C CZ    1 
ATOM   4083 N NH1   . ARG   A 1 675  ? 176.197 81.649  172.449 1.00 73.25  1  675  ARG   C NH1   1 
ATOM   4084 N NH2   . ARG   A 1 675  ? 175.915 79.495  173.137 1.00 75.21  ?  675  ARG   C NH2   1 
ATOM   4085 N N     . VAL   A 1 676  ? 171.023 84.708  167.129 1.00 36.60  ?  676  VAL   C N     1 
ATOM   4086 C CA    . VAL   A 1 676  ? 169.826 85.384  166.641 1.00 36.27  ?  676  VAL   C CA    1 
ATOM   4087 C C     . VAL   A 1 676  ? 169.003 84.433  165.800 1.00 37.58  ?  676  VAL   C C     1 
ATOM   4088 O O     . VAL   A 1 676  ? 169.484 83.915  164.796 1.00 39.16  ?  676  VAL   C O     1 
ATOM   4089 C CB    . VAL   A 1 676  ? 170.197 86.604  165.784 1.00 36.08  ?  676  VAL   C CB    1 
ATOM   4090 C CG1   . VAL   A 1 676  ? 168.932 87.248  165.178 1.00 36.28  ?  676  VAL   C CG1   1 
ATOM   4091 C CG2   . VAL   A 1 676  ? 170.911 87.593  166.635 1.00 40.84  ?  676  VAL   C CG2   1 
ATOM   4092 N N     . GLU   A 1 677  ? 167.757 84.218  166.191 1.00 35.82  ?  677  GLU   C N     1 
ATOM   4093 C CA    . GLU   A 1 677  ? 166.903 83.311  165.445 1.00 33.59  ?  677  GLU   C CA    1 
ATOM   4094 C C     . GLU   A 1 677  ? 165.966 84.066  164.514 1.00 30.48  ?  677  GLU   C C     1 
ATOM   4095 O O     . GLU   A 1 677  ? 165.660 83.588  163.420 1.00 32.95  ?  677  GLU   C O     1 
ATOM   4096 C CB    . GLU   A 1 677  ? 166.098 82.426  166.398 1.00 35.54  ?  677  GLU   C CB    1 
ATOM   4097 C CG    . GLU   A 1 677  ? 166.948 81.476  167.239 1.00 40.49  ?  677  GLU   C CG    1 
ATOM   4098 C CD    . GLU   A 1 677  ? 166.128 80.621  168.168 1.00 58.07  ?  677  GLU   C CD    1 
ATOM   4099 O OE1   . GLU   A 1 677  ? 164.943 80.838  168.250 1.00 56.88  ?  677  GLU   C OE1   1 
ATOM   4100 O OE2   . GLU   A 1 677  ? 166.686 79.749  168.794 1.00 54.89  -1 677  GLU   C OE2   1 
ATOM   4101 N N     . SER   A 1 678  ? 165.531 85.251  164.931 1.00 26.87  ?  678  SER   C N     1 
ATOM   4102 C CA    . SER   A 1 678  ? 164.581 86.018  164.128 1.00 24.73  ?  678  SER   C CA    1 
ATOM   4103 C C     . SER   A 1 678  ? 164.995 87.471  163.968 1.00 26.66  ?  678  SER   C C     1 
ATOM   4104 O O     . SER   A 1 678  ? 165.223 88.179  164.951 1.00 33.69  ?  678  SER   C O     1 
ATOM   4105 C CB    . SER   A 1 678  ? 163.198 85.947  164.738 1.00 31.03  ?  678  SER   C CB    1 
ATOM   4106 O OG    . SER   A 1 678  ? 162.299 86.755  164.031 1.00 29.53  ?  678  SER   C OG    1 
ATOM   4107 N N     . LEU   A 1 679  ? 165.108 87.899  162.715 1.00 21.88  ?  679  LEU   C N     1 
ATOM   4108 C CA    . LEU   A 1 679  ? 165.525 89.253  162.377 1.00 20.16  ?  679  LEU   C CA    1 
ATOM   4109 C C     . LEU   A 1 679  ? 164.489 89.983  161.539 1.00 17.79  ?  679  LEU   C C     1 
ATOM   4110 O O     . LEU   A 1 679  ? 164.025 89.460  160.525 1.00 22.91  ?  679  LEU   C O     1 
ATOM   4111 C CB    . LEU   A 1 679  ? 166.839 89.212  161.598 1.00 19.86  ?  679  LEU   C CB    1 
ATOM   4112 C CG    . LEU   A 1 679  ? 167.334 90.547  161.038 1.00 22.93  ?  679  LEU   C CG    1 
ATOM   4113 C CD1   . LEU   A 1 679  ? 167.734 91.468  162.161 1.00 32.38  ?  679  LEU   C CD1   1 
ATOM   4114 C CD2   . LEU   A 1 679  ? 168.481 90.285  160.147 1.00 25.71  ?  679  LEU   C CD2   1 
ATOM   4115 N N     . SER   A 1 680  ? 164.161 91.203  161.943 1.00 17.84  ?  680  SER   C N     1 
ATOM   4116 C CA    . SER   A 1 680  ? 163.247 92.046  161.188 1.00 16.40  ?  680  SER   C CA    1 
ATOM   4117 C C     . SER   A 1 680  ? 163.908 93.363  160.823 1.00 20.96  ?  680  SER   C C     1 
ATOM   4118 O O     . SER   A 1 680  ? 164.352 94.114  161.696 1.00 30.16  ?  680  SER   C O     1 
ATOM   4119 C CB    . SER   A 1 680  ? 161.982 92.305  161.977 1.00 19.86  ?  680  SER   C CB    1 
ATOM   4120 O OG    . SER   A 1 680  ? 161.133 93.181  161.286 1.00 21.03  ?  680  SER   C OG    1 
ATOM   4121 N N     . LEU   A 1 681  ? 164.012 93.623  159.526 1.00 18.79  ?  681  LEU   C N     1 
ATOM   4122 C CA    . LEU   A 1 681  ? 164.667 94.836  159.048 1.00 19.36  ?  681  LEU   C CA    1 
ATOM   4123 C C     . LEU   A 1 681  ? 163.683 95.782  158.391 1.00 22.04  ?  681  LEU   C C     1 
ATOM   4124 O O     . LEU   A 1 681  ? 163.357 95.642  157.212 1.00 27.78  ?  681  LEU   C O     1 
ATOM   4125 C CB    . LEU   A 1 681  ? 165.770 94.494  158.044 1.00 21.35  ?  681  LEU   C CB    1 
ATOM   4126 C CG    . LEU   A 1 681  ? 166.890 93.584  158.539 1.00 23.87  ?  681  LEU   C CG    1 
ATOM   4127 C CD1   . LEU   A 1 681  ? 167.777 93.212  157.367 1.00 31.75  ?  681  LEU   C CD1   1 
ATOM   4128 C CD2   . LEU   A 1 681  ? 167.691 94.308  159.608 1.00 31.20  ?  681  LEU   C CD2   1 
ATOM   4129 N N     . GLY   A 1 682  ? 163.208 96.751  159.156 1.00 24.25  ?  682  GLY   C N     1 
ATOM   4130 C CA    . GLY   A 1 682  ? 162.225 97.701  158.665 1.00 28.89  ?  682  GLY   C CA    1 
ATOM   4131 C C     . GLY   A 1 682  ? 162.917 98.868  157.985 1.00 38.32  ?  682  GLY   C C     1 
ATOM   4132 O O     . GLY   A 1 682  ? 162.960 99.971  158.528 1.00 41.51  ?  682  GLY   C O     1 
ATOM   4133 N N     . PHE   A 1 683  ? 163.480 98.616  156.809 1.00 33.27  ?  683  PHE   C N     1 
ATOM   4134 C CA    . PHE   A 1 683  ? 164.241 99.642  156.107 1.00 33.20  ?  683  PHE   C CA    1 
ATOM   4135 C C     . PHE   A 1 683  ? 163.406 100.892 155.884 1.00 37.53  ?  683  PHE   C C     1 
ATOM   4136 O O     . PHE   A 1 683  ? 162.275 100.816 155.408 1.00 42.61  ?  683  PHE   C O     1 
ATOM   4137 C CB    . PHE   A 1 683  ? 164.691 99.137  154.740 1.00 31.65  ?  683  PHE   C CB    1 
ATOM   4138 C CG    . PHE   A 1 683  ? 165.718 98.065  154.766 1.00 34.39  ?  683  PHE   C CG    1 
ATOM   4139 C CD1   . PHE   A 1 683  ? 165.354 96.749  154.565 1.00 34.81  ?  683  PHE   C CD1   1 
ATOM   4140 C CD2   . PHE   A 1 683  ? 167.052 98.359  154.964 1.00 42.35  ?  683  PHE   C CD2   1 
ATOM   4141 C CE1   . PHE   A 1 683  ? 166.300 95.753  154.564 1.00 36.71  ?  683  PHE   C CE1   1 
ATOM   4142 C CE2   . PHE   A 1 683  ? 168.000 97.355  154.963 1.00 46.00  ?  683  PHE   C CE2   1 
ATOM   4143 C CZ    . PHE   A 1 683  ? 167.620 96.054  154.762 1.00 41.46  ?  683  PHE   C CZ    1 
ATOM   4144 N N     . LEU   A 1 684  ? 163.976 102.045 156.197 1.00 39.88  ?  684  LEU   C N     1 
ATOM   4145 C CA    . LEU   A 1 684  ? 163.299 103.312 155.980 1.00 46.51  ?  684  LEU   C CA    1 
ATOM   4146 C C     . LEU   A 1 684  ? 163.869 103.986 154.745 1.00 53.53  ?  684  LEU   C C     1 
ATOM   4147 O O     . LEU   A 1 684  ? 164.944 103.616 154.272 1.00 54.33  ?  684  LEU   C O     1 
ATOM   4148 C CB    . LEU   A 1 684  ? 163.467 104.219 157.199 1.00 51.63  ?  684  LEU   C CB    1 
ATOM   4149 C CG    . LEU   A 1 684  ? 163.031 103.621 158.554 1.00 51.92  ?  684  LEU   C CG    1 
ATOM   4150 C CD1   . LEU   A 1 684  ? 163.363 104.613 159.661 1.00 52.86  ?  684  LEU   C CD1   1 
ATOM   4151 C CD2   . LEU   A 1 684  ? 161.540 103.307 158.531 1.00 50.63  ?  684  LEU   C CD2   1 
ATOM   4152 N N     . HIS   A 1 685  ? 163.156 104.973 154.218 1.00 58.95  ?  685  HIS   C N     1 
ATOM   4153 C CA    . HIS   A 1 685  ? 163.647 105.699 153.054 1.00 67.43  ?  685  HIS   C CA    1 
ATOM   4154 C C     . HIS   A 1 685  ? 164.981 106.372 153.371 1.00 68.09  ?  685  HIS   C C     1 
ATOM   4155 O O     . HIS   A 1 685  ? 165.139 106.965 154.439 1.00 63.16  ?  685  HIS   C O     1 
ATOM   4156 C CB    . HIS   A 1 685  ? 162.633 106.760 152.612 1.00 75.44  ?  685  HIS   C CB    1 
ATOM   4157 C CG    . HIS   A 1 685  ? 162.978 107.413 151.311 1.00 82.03  ?  685  HIS   C CG    1 
ATOM   4158 N ND1   . HIS   A 1 685  ? 163.964 108.375 151.191 1.00 79.92  ?  685  HIS   C ND1   1 
ATOM   4159 C CD2   . HIS   A 1 685  ? 162.472 107.237 150.073 1.00 88.70  ?  685  HIS   C CD2   1 
ATOM   4160 C CE1   . HIS   A 1 685  ? 164.047 108.757 149.932 1.00 83.35  ?  685  HIS   C CE1   1 
ATOM   4161 N NE2   . HIS   A 1 685  ? 163.153 108.082 149.233 1.00 87.43  ?  685  HIS   C NE2   1 
ATOM   4162 N N     . ASN   A 1 686  ? 165.933 106.288 152.428 1.00 73.41  ?  686  ASN   C N     1 
ATOM   4163 C CA    . ASN   A 1 686  ? 167.262 106.886 152.563 1.00 75.34  ?  686  ASN   C CA    1 
ATOM   4164 C C     . ASN   A 1 686  ? 167.301 108.261 151.887 1.00 77.43  ?  686  ASN   C C     1 
ATOM   4165 O O     . ASN   A 1 686  ? 166.502 109.153 152.190 1.00 74.15  ?  686  ASN   C O     1 
ATOM   4166 C CB    . ASN   A 1 686  ? 168.335 105.942 151.985 1.00 72.99  ?  686  ASN   C CB    1 
ATOM   4167 C CG    . ASN   A 1 686  ? 169.808 106.387 152.264 1.00 72.02  ?  686  ASN   C CG    1 
ATOM   4168 O OD1   . ASN   A 1 686  ? 170.088 106.976 153.320 1.00 67.51  ?  686  ASN   C OD1   1 
ATOM   4169 N ND2   . ASN   A 1 686  ? 170.718 106.105 151.336 1.00 66.36  ?  686  ASN   C ND2   1 
ATOM   4170 N N     . LEU   A 1 725  ? 164.082 102.302 149.675 1.00 47.91  ?  725  LEU   C N     1 
ATOM   4171 C CA    . LEU   A 1 725  ? 165.448 101.998 149.265 1.00 54.38  ?  725  LEU   C CA    1 
ATOM   4172 C C     . LEU   A 1 725  ? 165.661 102.328 147.780 1.00 59.09  ?  725  LEU   C C     1 
ATOM   4173 O O     . LEU   A 1 725  ? 166.261 103.356 147.452 1.00 61.83  ?  725  LEU   C O     1 
ATOM   4174 C CB    . LEU   A 1 725  ? 165.786 100.506 149.555 1.00 50.73  ?  725  LEU   C CB    1 
ATOM   4175 C CG    . LEU   A 1 725  ? 165.926 100.063 151.073 1.00 53.17  ?  725  LEU   C CG    1 
ATOM   4176 C CD1   . LEU   A 1 725  ? 166.011 98.515  151.134 1.00 45.34  ?  725  LEU   C CD1   1 
ATOM   4177 C CD2   . LEU   A 1 725  ? 167.198 100.709 151.709 1.00 59.51  ?  725  LEU   C CD2   1 
ATOM   4178 N N     . THR   A 1 726  ? 165.195 101.434 146.885 1.00 54.73  ?  726  THR   C N     1 
ATOM   4179 C CA    . THR   A 1 726  ? 165.356 101.527 145.426 1.00 56.22  ?  726  THR   C CA    1 
ATOM   4180 C C     . THR   A 1 726  ? 166.809 101.801 145.022 1.00 62.67  ?  726  THR   C C     1 
ATOM   4181 O O     . THR   A 1 726  ? 167.088 102.615 144.142 1.00 60.22  ?  726  THR   C O     1 
ATOM   4182 C CB    . THR   A 1 726  ? 164.419 102.600 144.828 1.00 56.99  ?  726  THR   C CB    1 
ATOM   4183 O OG1   . THR   A 1 726  ? 163.132 102.503 145.455 1.00 52.47  ?  726  THR   C OG1   1 
ATOM   4184 C CG2   . THR   A 1 726  ? 164.244 102.380 143.329 1.00 57.54  ?  726  THR   C CG2   1 
ATOM   4185 N N     . SER   A 1 727  ? 167.734 101.101 145.675 1.00 62.83  ?  727  SER   C N     1 
ATOM   4186 C CA    . SER   A 1 727  ? 169.154 101.252 145.391 1.00 61.71  ?  727  SER   C CA    1 
ATOM   4187 C C     . SER   A 1 727  ? 169.945 100.064 145.933 1.00 63.50  ?  727  SER   C C     1 
ATOM   4188 O O     . SER   A 1 727  ? 169.402 99.205  146.627 1.00 61.24  ?  727  SER   C O     1 
ATOM   4189 C CB    . SER   A 1 727  ? 169.692 102.534 145.997 1.00 62.05  ?  727  SER   C CB    1 
ATOM   4190 O OG    . SER   A 1 727  ? 169.851 102.412 147.379 1.00 60.70  ?  727  SER   C OG    1 
ATOM   4191 N N     . SER   A 1 728  ? 171.241 100.041 145.633 1.00 63.68  ?  728  SER   C N     1 
ATOM   4192 C CA    . SER   A 1 728  ? 172.150 99.002  146.107 1.00 65.06  ?  728  SER   C CA    1 
ATOM   4193 C C     . SER   A 1 728  ? 172.633 99.283  147.530 1.00 61.39  ?  728  SER   C C     1 
ATOM   4194 O O     . SER   A 1 728  ? 173.426 98.530  148.093 1.00 58.37  ?  728  SER   C O     1 
ATOM   4195 C CB    . SER   A 1 728  ? 173.342 98.883  145.176 1.00 66.91  ?  728  SER   C CB    1 
ATOM   4196 O OG    . SER   A 1 728  ? 174.103 100.060 145.181 1.00 66.77  ?  728  SER   C OG    1 
ATOM   4197 N N     . PHE   A 1 729  ? 172.153 100.377 148.107 1.00 61.02  ?  729  PHE   C N     1 
ATOM   4198 C CA    . PHE   A 1 729  ? 172.543 100.826 149.434 1.00 60.41  ?  729  PHE   C CA    1 
ATOM   4199 C C     . PHE   A 1 729  ? 172.465 99.721  150.486 1.00 58.00  ?  729  PHE   C C     1 
ATOM   4200 O O     . PHE   A 1 729  ? 173.400 99.519  151.261 1.00 58.48  ?  729  PHE   C O     1 
ATOM   4201 C CB    . PHE   A 1 729  ? 171.647 102.007 149.816 1.00 61.81  ?  729  PHE   C CB    1 
ATOM   4202 C CG    . PHE   A 1 729  ? 171.742 102.484 151.217 1.00 64.93  ?  729  PHE   C CG    1 
ATOM   4203 C CD1   . PHE   A 1 729  ? 172.920 102.990 151.722 1.00 65.06  ?  729  PHE   C CD1   1 
ATOM   4204 C CD2   . PHE   A 1 729  ? 170.621 102.465 152.026 1.00 59.69  ?  729  PHE   C CD2   1 
ATOM   4205 C CE1   . PHE   A 1 729  ? 172.978 103.460 153.014 1.00 61.69  ?  729  PHE   C CE1   1 
ATOM   4206 C CE2   . PHE   A 1 729  ? 170.674 102.936 153.309 1.00 56.34  ?  729  PHE   C CE2   1 
ATOM   4207 C CZ    . PHE   A 1 729  ? 171.853 103.432 153.807 1.00 59.82  ?  729  PHE   C CZ    1 
ATOM   4208 N N     . CYS   A 1 730  ? 171.351 98.999  150.494 1.00 55.86  ?  730  CYS   C N     1 
ATOM   4209 C CA    . CYS   A 1 730  ? 171.095 97.959  151.482 1.00 52.05  ?  730  CYS   C CA    1 
ATOM   4210 C C     . CYS   A 1 730  ? 171.995 96.736  151.332 1.00 50.72  ?  730  CYS   C C     1 
ATOM   4211 O O     . CYS   A 1 730  ? 172.032 95.874  152.217 1.00 50.34  ?  730  CYS   C O     1 
ATOM   4212 C CB    . CYS   A 1 730  ? 169.649 97.511  151.374 1.00 48.81  ?  730  CYS   C CB    1 
ATOM   4213 S SG    . CYS   A 1 730  ? 169.268 96.758  149.784 1.00 55.97  ?  730  CYS   C SG    1 
ATOM   4214 N N     . ARG   A 1 731  ? 172.722 96.651  150.220 1.00 51.96  ?  731  ARG   C N     1 
ATOM   4215 C CA    . ARG   A 1 731  ? 173.603 95.519  149.957 1.00 52.52  ?  731  ARG   C CA    1 
ATOM   4216 C C     . ARG   A 1 731  ? 174.563 95.291  151.114 1.00 50.75  ?  731  ARG   C C     1 
ATOM   4217 O O     . ARG   A 1 731  ? 174.939 94.156  151.407 1.00 49.29  ?  731  ARG   C O     1 
ATOM   4218 C CB    . ARG   A 1 731  ? 174.405 95.735  148.682 1.00 53.74  ?  731  ARG   C CB    1 
ATOM   4219 C CG    . ARG   A 1 731  ? 175.310 94.567  148.285 1.00 53.45  ?  731  ARG   C CG    1 
ATOM   4220 C CD    . ARG   A 1 731  ? 176.112 94.871  147.069 1.00 56.49  ?  731  ARG   C CD    1 
ATOM   4221 N NE    . ARG   A 1 731  ? 175.278 95.062  145.890 1.00 58.14  ?  731  ARG   C NE    1 
ATOM   4222 C CZ    . ARG   A 1 731  ? 174.821 94.072  145.091 1.00 61.78  ?  731  ARG   C CZ    1 
ATOM   4223 N NH1   . ARG   A 1 731  ? 175.125 92.813  145.343 1.00 60.64  1  731  ARG   C NH1   1 
ATOM   4224 N NH2   . ARG   A 1 731  ? 174.063 94.371  144.051 1.00 60.56  ?  731  ARG   C NH2   1 
ATOM   4225 N N     . GLY   A 1 732  ? 174.969 96.384  151.761 1.00 50.62  ?  732  GLY   C N     1 
ATOM   4226 C CA    . GLY   A 1 732  ? 175.939 96.328  152.847 1.00 51.51  ?  732  GLY   C CA    1 
ATOM   4227 C C     . GLY   A 1 732  ? 175.493 95.436  154.003 1.00 49.09  ?  732  GLY   C C     1 
ATOM   4228 O O     . GLY   A 1 732  ? 176.327 94.900  154.730 1.00 49.02  ?  732  GLY   C O     1 
ATOM   4229 N N     . LEU   A 1 733  ? 174.181 95.292  154.193 1.00 46.31  ?  733  LEU   C N     1 
ATOM   4230 C CA    . LEU   A 1 733  ? 173.680 94.468  155.288 1.00 44.13  ?  733  LEU   C CA    1 
ATOM   4231 C C     . LEU   A 1 733  ? 173.237 93.089  154.825 1.00 44.99  ?  733  LEU   C C     1 
ATOM   4232 O O     . LEU   A 1 733  ? 173.408 92.100  155.540 1.00 43.63  ?  733  LEU   C O     1 
ATOM   4233 C CB    . LEU   A 1 733  ? 172.519 95.172  155.998 1.00 38.87  ?  733  LEU   C CB    1 
ATOM   4234 C CG    . LEU   A 1 733  ? 171.864 94.394  157.157 1.00 34.54  ?  733  LEU   C CG    1 
ATOM   4235 C CD1   . LEU   A 1 733  ? 172.910 94.032  158.210 1.00 39.39  ?  733  LEU   C CD1   1 
ATOM   4236 C CD2   . LEU   A 1 733  ? 170.787 95.261  157.771 1.00 31.97  ?  733  LEU   C CD2   1 
ATOM   4237 N N     . PHE   A 1 734  ? 172.672 93.001  153.634 1.00 45.35  ?  734  PHE   C N     1 
ATOM   4238 C CA    . PHE   A 1 734  ? 172.181 91.711  153.175 1.00 40.26  ?  734  PHE   C CA    1 
ATOM   4239 C C     . PHE   A 1 734  ? 173.330 90.711  153.074 1.00 43.08  ?  734  PHE   C C     1 
ATOM   4240 O O     . PHE   A 1 734  ? 173.177 89.539  153.425 1.00 45.99  ?  734  PHE   C O     1 
ATOM   4241 C CB    . PHE   A 1 734  ? 171.447 91.851  151.845 1.00 39.98  ?  734  PHE   C CB    1 
ATOM   4242 C CG    . PHE   A 1 734  ? 170.041 92.350  152.011 1.00 37.57  ?  734  PHE   C CG    1 
ATOM   4243 C CD1   . PHE   A 1 734  ? 169.678 93.633  151.641 1.00 40.49  ?  734  PHE   C CD1   1 
ATOM   4244 C CD2   . PHE   A 1 734  ? 169.072 91.526  152.549 1.00 38.81  ?  734  PHE   C CD2   1 
ATOM   4245 C CE1   . PHE   A 1 734  ? 168.373 94.066  151.808 1.00 39.89  ?  734  PHE   C CE1   1 
ATOM   4246 C CE2   . PHE   A 1 734  ? 167.781 91.963  152.713 1.00 38.64  ?  734  PHE   C CE2   1 
ATOM   4247 C CZ    . PHE   A 1 734  ? 167.433 93.229  152.340 1.00 37.64  ?  734  PHE   C CZ    1 
ATOM   4248 N N     . SER   A 1 735  ? 174.500 91.202  152.668 1.00 43.60  ?  735  SER   C N     1 
ATOM   4249 C CA    . SER   A 1 735  ? 175.700 90.379  152.526 1.00 45.83  ?  735  SER   C CA    1 
ATOM   4250 C C     . SER   A 1 735  ? 176.168 89.800  153.862 1.00 45.70  ?  735  SER   C C     1 
ATOM   4251 O O     . SER   A 1 735  ? 176.994 88.888  153.894 1.00 47.09  ?  735  SER   C O     1 
ATOM   4252 C CB    . SER   A 1 735  ? 176.816 91.206  151.926 1.00 50.93  ?  735  SER   C CB    1 
ATOM   4253 O OG    . SER   A 1 735  ? 177.292 92.147  152.847 1.00 49.73  ?  735  SER   C OG    1 
ATOM   4254 N N     . VAL   A 1 736  ? 175.648 90.341  154.960 1.00 44.36  ?  736  VAL   C N     1 
ATOM   4255 C CA    . VAL   A 1 736  ? 175.968 89.875  156.301 1.00 44.52  ?  736  VAL   C CA    1 
ATOM   4256 C C     . VAL   A 1 736  ? 175.054 88.725  156.680 1.00 45.49  ?  736  VAL   C C     1 
ATOM   4257 O O     . VAL   A 1 736  ? 175.457 87.785  157.363 1.00 45.69  ?  736  VAL   C O     1 
ATOM   4258 C CB    . VAL   A 1 736  ? 175.810 91.015  157.323 1.00 44.62  ?  736  VAL   C CB    1 
ATOM   4259 C CG1   . VAL   A 1 736  ? 176.016 90.500  158.731 1.00 45.31  ?  736  VAL   C CG1   1 
ATOM   4260 C CG2   . VAL   A 1 736  ? 176.801 92.107  157.006 1.00 50.01  ?  736  VAL   C CG2   1 
ATOM   4261 N N     . LEU   A 1 737  ? 173.804 88.816  156.256 1.00 44.55  ?  737  LEU   C N     1 
ATOM   4262 C CA    . LEU   A 1 737  ? 172.817 87.811  156.613 1.00 40.32  ?  737  LEU   C CA    1 
ATOM   4263 C C     . LEU   A 1 737  ? 173.219 86.456  156.056 1.00 43.57  ?  737  LEU   C C     1 
ATOM   4264 O O     . LEU   A 1 737  ? 173.004 85.423  156.689 1.00 42.39  ?  737  LEU   C O     1 
ATOM   4265 C CB    . LEU   A 1 737  ? 171.448 88.195  156.051 1.00 37.92  ?  737  LEU   C CB    1 
ATOM   4266 C CG    . LEU   A 1 737  ? 170.873 89.523  156.539 1.00 39.67  ?  737  LEU   C CG    1 
ATOM   4267 C CD1   . LEU   A 1 737  ? 169.515 89.737  155.888 1.00 37.49  ?  737  LEU   C CD1   1 
ATOM   4268 C CD2   . LEU   A 1 737  ? 170.784 89.523  158.033 1.00 36.61  ?  737  LEU   C CD2   1 
ATOM   4269 N N     . SER   A 1 738  ? 173.850 86.466  154.889 1.00 46.96  ?  738  SER   C N     1 
ATOM   4270 C CA    . SER   A 1 738  ? 174.283 85.242  154.223 1.00 48.60  ?  738  SER   C CA    1 
ATOM   4271 C C     . SER   A 1 738  ? 175.342 84.463  154.991 1.00 49.10  ?  738  SER   C C     1 
ATOM   4272 O O     . SER   A 1 738  ? 175.616 83.309  154.663 1.00 50.30  ?  738  SER   C O     1 
ATOM   4273 C CB    . SER   A 1 738  ? 174.835 85.559  152.855 1.00 51.74  ?  738  SER   C CB    1 
ATOM   4274 O OG    . SER   A 1 738  ? 176.002 86.321  152.949 1.00 50.87  ?  738  SER   C OG    1 
ATOM   4275 N N     . THR   A 1 739  ? 175.965 85.079  155.989 1.00 46.45  ?  739  THR   C N     1 
ATOM   4276 C CA    . THR   A 1 739  ? 177.004 84.387  156.732 1.00 48.63  ?  739  THR   C CA    1 
ATOM   4277 C C     . THR   A 1 739  ? 176.496 83.900  158.081 1.00 50.18  ?  739  THR   C C     1 
ATOM   4278 O O     . THR   A 1 739  ? 177.248 83.299  158.855 1.00 51.18  ?  739  THR   C O     1 
ATOM   4279 C CB    . THR   A 1 739  ? 178.232 85.291  156.926 1.00 51.84  ?  739  THR   C CB    1 
ATOM   4280 O OG1   . THR   A 1 739  ? 177.894 86.404  157.760 1.00 49.71  ?  739  THR   C OG1   1 
ATOM   4281 C CG2   . THR   A 1 739  ? 178.683 85.811  155.570 1.00 54.49  ?  739  THR   C CG2   1 
ATOM   4282 N N     . SER   A 1 740  ? 175.226 84.165  158.374 1.00 47.52  ?  740  SER   C N     1 
ATOM   4283 C CA    . SER   A 1 740  ? 174.639 83.737  159.633 1.00 46.62  ?  740  SER   C CA    1 
ATOM   4284 C C     . SER   A 1 740  ? 174.482 82.228  159.665 1.00 44.48  ?  740  SER   C C     1 
ATOM   4285 O O     . SER   A 1 740  ? 174.127 81.608  158.664 1.00 47.13  ?  740  SER   C O     1 
ATOM   4286 C CB    . SER   A 1 740  ? 173.302 84.405  159.860 1.00 43.60  ?  740  SER   C CB    1 
ATOM   4287 O OG    . SER   A 1 740  ? 172.698 83.931  161.040 1.00 39.77  ?  740  SER   C OG    1 
ATOM   4288 N N     . GLN   A 1 741  ? 174.747 81.635  160.818 1.00 42.73  ?  741  GLN   C N     1 
ATOM   4289 C CA    . GLN   A 1 741  ? 174.647 80.192  160.943 1.00 44.67  ?  741  GLN   C CA    1 
ATOM   4290 C C     . GLN   A 1 741  ? 173.378 79.766  161.658 1.00 45.01  ?  741  GLN   C C     1 
ATOM   4291 O O     . GLN   A 1 741  ? 172.964 78.611  161.562 1.00 47.19  ?  741  GLN   C O     1 
ATOM   4292 C CB    . GLN   A 1 741  ? 175.875 79.657  161.668 1.00 45.16  ?  741  GLN   C CB    1 
ATOM   4293 C CG    . GLN   A 1 741  ? 177.171 80.006  160.969 1.00 51.90  ?  741  GLN   C CG    1 
ATOM   4294 C CD    . GLN   A 1 741  ? 177.221 79.463  159.557 1.00 57.11  ?  741  GLN   C CD    1 
ATOM   4295 O OE1   . GLN   A 1 741  ? 177.107 78.251  159.344 1.00 56.26  ?  741  GLN   C OE1   1 
ATOM   4296 N NE2   . GLN   A 1 741  ? 177.382 80.352  158.584 1.00 54.36  ?  741  GLN   C NE2   1 
ATOM   4297 N N     . SER   A 1 742  ? 172.776 80.688  162.400 1.00 39.14  ?  742  SER   C N     1 
ATOM   4298 C CA    . SER   A 1 742  ? 171.616 80.359  163.214 1.00 38.61  ?  742  SER   C CA    1 
ATOM   4299 C C     . SER   A 1 742  ? 170.343 81.116  162.835 1.00 35.57  ?  742  SER   C C     1 
ATOM   4300 O O     . SER   A 1 742  ? 169.258 80.760  163.295 1.00 37.43  ?  742  SER   C O     1 
ATOM   4301 C CB    . SER   A 1 742  ? 171.956 80.589  164.670 1.00 44.99  ?  742  SER   C CB    1 
ATOM   4302 O OG    . SER   A 1 742  ? 172.312 81.922  164.900 1.00 46.51  ?  742  SER   C OG    1 
ATOM   4303 N N     . LEU   A 1 743  ? 170.448 82.145  161.993 1.00 32.46  ?  743  LEU   C N     1 
ATOM   4304 C CA    . LEU   A 1 743  ? 169.243 82.898  161.643 1.00 30.04  ?  743  LEU   C CA    1 
ATOM   4305 C C     . LEU   A 1 743  ? 168.241 81.989  160.956 1.00 32.43  ?  743  LEU   C C     1 
ATOM   4306 O O     . LEU   A 1 743  ? 168.585 81.285  160.010 1.00 34.13  ?  743  LEU   C O     1 
ATOM   4307 C CB    . LEU   A 1 743  ? 169.570 84.077  160.711 1.00 26.57  ?  743  LEU   C CB    1 
ATOM   4308 C CG    . LEU   A 1 743  ? 168.355 84.943  160.254 1.00 28.32  ?  743  LEU   C CG    1 
ATOM   4309 C CD1   . LEU   A 1 743  ? 167.771 85.686  161.450 1.00 30.93  ?  743  LEU   C CD1   1 
ATOM   4310 C CD2   . LEU   A 1 743  ? 168.806 85.933  159.179 1.00 32.26  ?  743  LEU   C CD2   1 
ATOM   4311 N N     . THR   A 1 744  ? 166.998 82.011  161.425 1.00 30.04  ?  744  THR   C N     1 
ATOM   4312 C CA    . THR   A 1 744  ? 165.957 81.172  160.862 1.00 25.02  ?  744  THR   C CA    1 
ATOM   4313 C C     . THR   A 1 744  ? 164.901 81.989  160.132 1.00 23.03  ?  744  THR   C C     1 
ATOM   4314 O O     . THR   A 1 744  ? 164.481 81.628  159.028 1.00 27.01  ?  744  THR   C O     1 
ATOM   4315 C CB    . THR   A 1 744  ? 165.282 80.347  161.973 1.00 27.58  ?  744  THR   C CB    1 
ATOM   4316 O OG1   . THR   A 1 744  ? 166.263 79.517  162.608 1.00 31.38  ?  744  THR   C OG1   1 
ATOM   4317 C CG2   . THR   A 1 744  ? 164.183 79.474  161.404 1.00 31.51  ?  744  THR   C CG2   1 
ATOM   4318 N N     . GLU   A 1 745  ? 164.460 83.079  160.752 1.00 20.76  ?  745  GLU   C N     1 
ATOM   4319 C CA    . GLU   A 1 745  ? 163.370 83.866  160.190 1.00 16.69  ?  745  GLU   C CA    1 
ATOM   4320 C C     . GLU   A 1 745  ? 163.813 85.259  159.789 1.00 17.68  ?  745  GLU   C C     1 
ATOM   4321 O O     . GLU   A 1 745  ? 164.329 86.020  160.608 1.00 26.88  ?  745  GLU   C O     1 
ATOM   4322 C CB    . GLU   A 1 745  ? 162.227 83.989  161.199 1.00 24.62  ?  745  GLU   C CB    1 
ATOM   4323 C CG    . GLU   A 1 745  ? 161.644 82.671  161.652 1.00 31.69  ?  745  GLU   C CG    1 
ATOM   4324 C CD    . GLU   A 1 745  ? 160.441 82.837  162.552 1.00 34.24  ?  745  GLU   C CD    1 
ATOM   4325 O OE1   . GLU   A 1 745  ? 160.080 83.954  162.836 1.00 31.28  ?  745  GLU   C OE1   1 
ATOM   4326 O OE2   . GLU   A 1 745  ? 159.889 81.842  162.957 1.00 31.72  -1 745  GLU   C OE2   1 
ATOM   4327 N N     . LEU   A 1 746  ? 163.576 85.601  158.533 1.00 11.97  ?  746  LEU   C N     1 
ATOM   4328 C CA    . LEU   A 1 746  ? 163.898 86.927  158.035 1.00 8.66   ?  746  LEU   C CA    1 
ATOM   4329 C C     . LEU   A 1 746  ? 162.625 87.666  157.643 1.00 7.36   ?  746  LEU   C C     1 
ATOM   4330 O O     . LEU   A 1 746  ? 161.880 87.224  156.769 1.00 13.75  ?  746  LEU   C O     1 
ATOM   4331 C CB    . LEU   A 1 746  ? 164.857 86.823  156.842 1.00 10.02  ?  746  LEU   C CB    1 
ATOM   4332 C CG    . LEU   A 1 746  ? 165.219 88.143  156.144 1.00 10.86  ?  746  LEU   C CG    1 
ATOM   4333 C CD1   . LEU   A 1 746  ? 165.937 89.067  157.123 1.00 21.97  ?  746  LEU   C CD1   1 
ATOM   4334 C CD2   . LEU   A 1 746  ? 166.112 87.844  154.948 1.00 17.35  ?  746  LEU   C CD2   1 
ATOM   4335 N N     . ASP   A 1 747  ? 162.364 88.773  158.320 1.00 10.11  ?  747  ASP   C N     1 
ATOM   4336 C CA    . ASP   A 1 747  ? 161.161 89.564  158.092 1.00 9.28   ?  747  ASP   C CA    1 
ATOM   4337 C C     . ASP   A 1 747  ? 161.489 90.890  157.422 1.00 13.57  ?  747  ASP   C C     1 
ATOM   4338 O O     . ASP   A 1 747  ? 162.202 91.726  157.980 1.00 21.88  ?  747  ASP   C O     1 
ATOM   4339 C CB    . ASP   A 1 747  ? 160.411 89.787  159.406 1.00 16.35  ?  747  ASP   C CB    1 
ATOM   4340 C CG    . ASP   A 1 747  ? 159.097 90.553  159.245 1.00 20.11  ?  747  ASP   C CG    1 
ATOM   4341 O OD1   . ASP   A 1 747  ? 158.932 91.230  158.249 1.00 16.90  ?  747  ASP   C OD1   1 
ATOM   4342 O OD2   . ASP   A 1 747  ? 158.271 90.455  160.122 1.00 22.76  -1 747  ASP   C OD2   1 
ATOM   4343 N N     . LEU   A 1 748  ? 161.032 91.048  156.190 1.00 7.03   ?  748  LEU   C N     1 
ATOM   4344 C CA    . LEU   A 1 748  ? 161.326 92.242  155.417 1.00 12.99  ?  748  LEU   C CA    1 
ATOM   4345 C C     . LEU   A 1 748  ? 160.046 92.952  155.027 1.00 12.25  ?  748  LEU   C C     1 
ATOM   4346 O O     . LEU   A 1 748  ? 159.971 93.581  153.973 1.00 16.36  ?  748  LEU   C O     1 
ATOM   4347 C CB    . LEU   A 1 748  ? 162.127 91.871  154.177 1.00 0.36   ?  748  LEU   C CB    1 
ATOM   4348 C CG    . LEU   A 1 748  ? 163.475 91.241  154.457 1.00 11.56  ?  748  LEU   C CG    1 
ATOM   4349 C CD1   . LEU   A 1 748  ? 163.980 90.613  153.220 1.00 17.55  ?  748  LEU   C CD1   1 
ATOM   4350 C CD2   . LEU   A 1 748  ? 164.436 92.292  154.926 1.00 21.38  ?  748  LEU   C CD2   1 
ATOM   4351 N N     . SER   A 1 749  ? 159.032 92.826  155.866 1.00 11.41  ?  749  SER   C N     1 
ATOM   4352 C CA    . SER   A 1 749  ? 157.731 93.417  155.600 1.00 14.38  ?  749  SER   C CA    1 
ATOM   4353 C C     . SER   A 1 749  ? 157.691 94.927  155.793 1.00 17.84  ?  749  SER   C C     1 
ATOM   4354 O O     . SER   A 1 749  ? 158.561 95.518  156.432 1.00 24.18  ?  749  SER   C O     1 
ATOM   4355 C CB    . SER   A 1 749  ? 156.685 92.765  156.482 1.00 16.78  ?  749  SER   C CB    1 
ATOM   4356 O OG    . SER   A 1 749  ? 156.922 93.039  157.835 1.00 18.10  ?  749  SER   C OG    1 
ATOM   4357 N N     . ASP   A 1 750  ? 156.656 95.541  155.229 1.00 19.03  ?  750  ASP   C N     1 
ATOM   4358 C CA    . ASP   A 1 750  ? 156.348 96.959  155.389 1.00 20.55  ?  750  ASP   C CA    1 
ATOM   4359 C C     . ASP   A 1 750  ? 157.490 97.914  155.054 1.00 24.90  ?  750  ASP   C C     1 
ATOM   4360 O O     . ASP   A 1 750  ? 157.706 98.895  155.765 1.00 31.37  ?  750  ASP   C O     1 
ATOM   4361 C CB    . ASP   A 1 750  ? 155.871 97.235  156.815 1.00 25.69  ?  750  ASP   C CB    1 
ATOM   4362 C CG    . ASP   A 1 750  ? 154.570 96.518  157.157 1.00 29.98  ?  750  ASP   C CG    1 
ATOM   4363 O OD1   . ASP   A 1 750  ? 153.892 96.094  156.249 1.00 27.90  ?  750  ASP   C OD1   1 
ATOM   4364 O OD2   . ASP   A 1 750  ? 154.261 96.410  158.321 1.00 31.78  -1 750  ASP   C OD2   1 
ATOM   4365 N N     . ASN   A 1 751  ? 158.199 97.659  153.964 1.00 21.43  ?  751  ASN   C N     1 
ATOM   4366 C CA    . ASN   A 1 751  ? 159.245 98.576  153.525 1.00 23.03  ?  751  ASN   C CA    1 
ATOM   4367 C C     . ASN   A 1 751  ? 159.408 98.492  152.017 1.00 23.44  ?  751  ASN   C C     1 
ATOM   4368 O O     . ASN   A 1 751  ? 159.067 97.478  151.409 1.00 26.75  ?  751  ASN   C O     1 
ATOM   4369 C CB    . ASN   A 1 751  ? 160.546 98.289  154.236 1.00 26.04  ?  751  ASN   C CB    1 
ATOM   4370 C CG    . ASN   A 1 751  ? 161.101 96.989  153.862 1.00 28.87  ?  751  ASN   C CG    1 
ATOM   4371 O OD1   . ASN   A 1 751  ? 161.958 96.906  152.980 1.00 32.06  ?  751  ASN   C OD1   1 
ATOM   4372 N ND2   . ASN   A 1 751  ? 160.640 95.960  154.497 1.00 24.62  ?  751  ASN   C ND2   1 
ATOM   4373 N N     . SER   A 1 752  ? 159.958 99.540  151.413 1.00 23.24  ?  752  SER   C N     1 
ATOM   4374 C CA    . SER   A 1 752  ? 160.080 99.601  149.961 1.00 23.66  ?  752  SER   C CA    1 
ATOM   4375 C C     . SER   A 1 752  ? 161.266 98.821  149.409 1.00 26.84  ?  752  SER   C C     1 
ATOM   4376 O O     . SER   A 1 752  ? 162.154 99.384  148.764 1.00 34.55  ?  752  SER   C O     1 
ATOM   4377 C CB    . SER   A 1 752  ? 160.182 101.043 149.519 1.00 29.10  ?  752  SER   C CB    1 
ATOM   4378 O OG    . SER   A 1 752  ? 159.024 101.756 149.854 1.00 33.15  ?  752  SER   C OG    1 
ATOM   4379 N N     . LEU   A 1 753  ? 161.242 97.511  149.605 1.00 26.51  ?  753  LEU   C N     1 
ATOM   4380 C CA    . LEU   A 1 753  ? 162.268 96.635  149.055 1.00 24.25  ?  753  LEU   C CA    1 
ATOM   4381 C C     . LEU   A 1 753  ? 161.867 96.273  147.638 1.00 28.06  ?  753  LEU   C C     1 
ATOM   4382 O O     . LEU   A 1 753  ? 161.556 95.121  147.336 1.00 35.67  ?  753  LEU   C O     1 
ATOM   4383 C CB    . LEU   A 1 753  ? 162.399 95.359  149.900 1.00 25.60  ?  753  LEU   C CB    1 
ATOM   4384 C CG    . LEU   A 1 753  ? 163.582 94.419  149.575 1.00 29.26  ?  753  LEU   C CG    1 
ATOM   4385 C CD1   . LEU   A 1 753  ? 164.903 95.054  150.028 1.00 37.90  ?  753  LEU   C CD1   1 
ATOM   4386 C CD2   . LEU   A 1 753  ? 163.360 93.093  150.268 1.00 30.36  ?  753  LEU   C CD2   1 
ATOM   4387 N N     . GLY   A 1 754  ? 161.880 97.277  146.771 1.00 27.65  ?  754  GLY   C N     1 
ATOM   4388 C CA    . GLY   A 1 754  ? 161.389 97.131  145.410 1.00 30.60  ?  754  GLY   C CA    1 
ATOM   4389 C C     . GLY   A 1 754  ? 162.348 96.324  144.556 1.00 35.08  ?  754  GLY   C C     1 
ATOM   4390 O O     . GLY   A 1 754  ? 163.328 95.777  145.056 1.00 37.82  ?  754  GLY   C O     1 
ATOM   4391 N N     . ASP   A 1 755  ? 162.058 96.244  143.263 1.00 30.22  ?  755  ASP   C N     1 
ATOM   4392 C CA    . ASP   A 1 755  ? 162.796 95.386  142.343 1.00 32.01  ?  755  ASP   C CA    1 
ATOM   4393 C C     . ASP   A 1 755  ? 164.291 95.173  142.677 1.00 38.04  ?  755  ASP   C C     1 
ATOM   4394 O O     . ASP   A 1 755  ? 164.681 94.025  142.889 1.00 40.42  ?  755  ASP   C O     1 
ATOM   4395 C CB    . ASP   A 1 755  ? 162.616 95.876  140.906 1.00 38.04  ?  755  ASP   C CB    1 
ATOM   4396 C CG    . ASP   A 1 755  ? 161.189 95.682  140.411 1.00 44.66  ?  755  ASP   C CG    1 
ATOM   4397 O OD1   . ASP   A 1 755  ? 160.407 95.091  141.119 1.00 41.37  ?  755  ASP   C OD1   1 
ATOM   4398 O OD2   . ASP   A 1 755  ? 160.892 96.137  139.331 1.00 49.39  -1 755  ASP   C OD2   1 
ATOM   4399 N N     . PRO   A 1 756  ? 165.154 96.214  142.713 1.00 37.93  ?  756  PRO   C N     1 
ATOM   4400 C CA    . PRO   A 1 756  ? 166.582 96.101  142.973 1.00 39.15  ?  756  PRO   C CA    1 
ATOM   4401 C C     . PRO   A 1 756  ? 166.876 95.578  144.375 1.00 41.55  ?  756  PRO   C C     1 
ATOM   4402 O O     . PRO   A 1 756  ? 167.942 95.009  144.623 1.00 44.60  ?  756  PRO   C O     1 
ATOM   4403 C CB    . PRO   A 1 756  ? 167.068 97.548  142.806 1.00 46.88  ?  756  PRO   C CB    1 
ATOM   4404 C CG    . PRO   A 1 756  ? 165.846 98.398  143.018 1.00 45.54  ?  756  PRO   C CG    1 
ATOM   4405 C CD    . PRO   A 1 756  ? 164.710 97.596  142.449 1.00 40.77  ?  756  PRO   C CD    1 
ATOM   4406 N N     . GLY   A 1 757  ? 165.930 95.768  145.288 1.00 39.60  ?  757  GLY   C N     1 
ATOM   4407 C CA    . GLY   A 1 757  ? 166.074 95.302  146.658 1.00 42.56  ?  757  GLY   C CA    1 
ATOM   4408 C C     . GLY   A 1 757  ? 165.875 93.804  146.685 1.00 43.27  ?  757  GLY   C C     1 
ATOM   4409 O O     . GLY   A 1 757  ? 166.627 93.062  147.321 1.00 42.99  ?  757  GLY   C O     1 
ATOM   4410 N N     . MET   A 1 758  ? 164.864 93.360  145.962 1.00 40.36  ?  758  MET   C N     1 
ATOM   4411 C CA    . MET   A 1 758  ? 164.584 91.948  145.864 1.00 39.03  ?  758  MET   C CA    1 
ATOM   4412 C C     . MET   A 1 758  ? 165.719 91.253  145.135 1.00 42.16  ?  758  MET   C C     1 
ATOM   4413 O O     . MET   A 1 758  ? 166.058 90.114  145.451 1.00 42.16  ?  758  MET   C O     1 
ATOM   4414 C CB    . MET   A 1 758  ? 163.259 91.720  145.150 1.00 35.10  ?  758  MET   C CB    1 
ATOM   4415 C CG    . MET   A 1 758  ? 162.728 90.301  145.245 1.00 32.32  ?  758  MET   C CG    1 
ATOM   4416 S SD    . MET   A 1 758  ? 162.290 89.848  146.926 1.00 32.77  ?  758  MET   C SD    1 
ATOM   4417 C CE    . MET   A 1 758  ? 163.474 88.550  147.271 1.00 36.52  ?  758  MET   C CE    1 
ATOM   4418 N N     . ARG   A 1 759  ? 166.316 91.940  144.163 1.00 40.36  ?  759  ARG   C N     1 
ATOM   4419 C CA    . ARG   A 1 759  ? 167.394 91.350  143.385 1.00 41.68  ?  759  ARG   C CA    1 
ATOM   4420 C C     . ARG   A 1 759  ? 168.633 91.084  144.232 1.00 42.44  ?  759  ARG   C C     1 
ATOM   4421 O O     . ARG   A 1 759  ? 169.207 89.995  144.160 1.00 45.76  ?  759  ARG   C O     1 
ATOM   4422 C CB    . ARG   A 1 759  ? 167.758 92.245  142.215 1.00 39.63  ?  759  ARG   C CB    1 
ATOM   4423 C CG    . ARG   A 1 759  ? 168.771 91.656  141.255 1.00 39.34  ?  759  ARG   C CG    1 
ATOM   4424 C CD    . ARG   A 1 759  ? 168.843 92.448  140.008 1.00 44.66  ?  759  ARG   C CD    1 
ATOM   4425 N NE    . ARG   A 1 759  ? 169.805 91.905  139.062 1.00 50.15  ?  759  ARG   C NE    1 
ATOM   4426 C CZ    . ARG   A 1 759  ? 169.572 90.870  138.220 1.00 51.74  ?  759  ARG   C CZ    1 
ATOM   4427 N NH1   . ARG   A 1 759  ? 168.405 90.252  138.212 1.00 45.27  1  759  ARG   C NH1   1 
ATOM   4428 N NH2   . ARG   A 1 759  ? 170.526 90.472  137.393 1.00 51.94  ?  759  ARG   C NH2   1 
ATOM   4429 N N     . VAL   A 1 760  ? 169.039 92.052  145.056 1.00 41.25  ?  760  VAL   C N     1 
ATOM   4430 C CA    . VAL   A 1 760  ? 170.215 91.835  145.893 1.00 41.33  ?  760  VAL   C CA    1 
ATOM   4431 C C     . VAL   A 1 760  ? 169.934 90.771  146.941 1.00 42.65  ?  760  VAL   C C     1 
ATOM   4432 O O     . VAL   A 1 760  ? 170.810 89.970  147.275 1.00 43.74  ?  760  VAL   C O     1 
ATOM   4433 C CB    . VAL   A 1 760  ? 170.700 93.148  146.555 1.00 42.86  ?  760  VAL   C CB    1 
ATOM   4434 C CG1   . VAL   A 1 760  ? 169.738 93.636  147.622 1.00 42.21  ?  760  VAL   C CG1   1 
ATOM   4435 C CG2   . VAL   A 1 760  ? 172.057 92.912  147.169 1.00 48.22  ?  760  VAL   C CG2   1 
ATOM   4436 N N     . LEU   A 1 761  ? 168.705 90.740  147.441 1.00 43.07  ?  761  LEU   C N     1 
ATOM   4437 C CA    . LEU   A 1 761  ? 168.322 89.712  148.388 1.00 43.76  ?  761  LEU   C CA    1 
ATOM   4438 C C     . LEU   A 1 761  ? 168.329 88.341  147.728 1.00 44.09  ?  761  LEU   C C     1 
ATOM   4439 O O     . LEU   A 1 761  ? 168.810 87.370  148.307 1.00 43.12  ?  761  LEU   C O     1 
ATOM   4440 C CB    . LEU   A 1 761  ? 166.952 90.023  148.981 1.00 40.00  ?  761  LEU   C CB    1 
ATOM   4441 C CG    . LEU   A 1 761  ? 166.352 88.957  149.900 1.00 36.03  ?  761  LEU   C CG    1 
ATOM   4442 C CD1   . LEU   A 1 761  ? 167.281 88.652  151.065 1.00 35.92  ?  761  LEU   C CD1   1 
ATOM   4443 C CD2   . LEU   A 1 761  ? 165.055 89.474  150.409 1.00 34.06  ?  761  LEU   C CD2   1 
ATOM   4444 N N     . CYS   A 1 762  ? 167.825 88.255  146.505 1.00 43.89  ?  762  CYS   C N     1 
ATOM   4445 C CA    . CYS   A 1 762  ? 167.818 86.972  145.823 1.00 42.61  ?  762  CYS   C CA    1 
ATOM   4446 C C     . CYS   A 1 762  ? 169.228 86.435  145.641 1.00 44.47  ?  762  CYS   C C     1 
ATOM   4447 O O     . CYS   A 1 762  ? 169.464 85.243  145.830 1.00 43.58  ?  762  CYS   C O     1 
ATOM   4448 C CB    . CYS   A 1 762  ? 167.121 87.074  144.481 1.00 45.57  ?  762  CYS   C CB    1 
ATOM   4449 S SG    . CYS   A 1 762  ? 165.360 87.316  144.642 1.00 55.66  ?  762  CYS   C SG    1 
ATOM   4450 N N     . GLU   A 1 763  ? 170.180 87.309  145.317 1.00 45.65  ?  763  GLU   C N     1 
ATOM   4451 C CA    . GLU   A 1 763  ? 171.567 86.868  145.217 1.00 47.23  ?  763  GLU   C CA    1 
ATOM   4452 C C     . GLU   A 1 763  ? 172.043 86.364  146.574 1.00 45.93  ?  763  GLU   C C     1 
ATOM   4453 O O     . GLU   A 1 763  ? 172.703 85.333  146.678 1.00 48.24  ?  763  GLU   C O     1 
ATOM   4454 C CB    . GLU   A 1 763  ? 172.488 88.012  144.772 1.00 50.02  ?  763  GLU   C CB    1 
ATOM   4455 C CG    . GLU   A 1 763  ? 172.325 88.475  143.331 1.00 55.12  ?  763  GLU   C CG    1 
ATOM   4456 C CD    . GLU   A 1 763  ? 173.203 89.671  143.004 1.00 60.71  ?  763  GLU   C CD    1 
ATOM   4457 O OE1   . GLU   A 1 763  ? 173.737 90.261  143.922 1.00 57.15  ?  763  GLU   C OE1   1 
ATOM   4458 O OE2   . GLU   A 1 763  ? 173.340 89.987  141.845 1.00 57.06  -1 763  GLU   C OE2   1 
ATOM   4459 N N     . THR   A 1 764  ? 171.661 87.088  147.619 1.00 44.59  ?  764  THR   C N     1 
ATOM   4460 C CA    . THR   A 1 764  ? 172.045 86.775  148.988 1.00 44.36  ?  764  THR   C CA    1 
ATOM   4461 C C     . THR   A 1 764  ? 171.523 85.402  149.398 1.00 45.73  ?  764  THR   C C     1 
ATOM   4462 O O     . THR   A 1 764  ? 172.222 84.619  150.045 1.00 47.50  ?  764  THR   C O     1 
ATOM   4463 C CB    . THR   A 1 764  ? 171.498 87.862  149.941 1.00 46.66  ?  764  THR   C CB    1 
ATOM   4464 O OG1   . THR   A 1 764  ? 172.018 89.146  149.550 1.00 46.32  ?  764  THR   C OG1   1 
ATOM   4465 C CG2   . THR   A 1 764  ? 171.904 87.594  151.359 1.00 47.41  ?  764  THR   C CG2   1 
ATOM   4466 N N     . LEU   A 1 765  ? 170.298 85.099  148.995 1.00 43.34  ?  765  LEU   C N     1 
ATOM   4467 C CA    . LEU   A 1 765  ? 169.631 83.861  149.365 1.00 40.58  ?  765  LEU   C CA    1 
ATOM   4468 C C     . LEU   A 1 765  ? 170.138 82.648  148.589 1.00 42.99  ?  765  LEU   C C     1 
ATOM   4469 O O     . LEU   A 1 765  ? 169.715 81.520  148.852 1.00 43.58  ?  765  LEU   C O     1 
ATOM   4470 C CB    . LEU   A 1 765  ? 168.126 84.009  149.142 1.00 40.05  ?  765  LEU   C CB    1 
ATOM   4471 C CG    . LEU   A 1 765  ? 167.413 85.045  150.016 1.00 39.86  ?  765  LEU   C CG    1 
ATOM   4472 C CD1   . LEU   A 1 765  ? 166.032 85.273  149.458 1.00 39.97  ?  765  LEU   C CD1   1 
ATOM   4473 C CD2   . LEU   A 1 765  ? 167.334 84.552  151.448 1.00 35.63  ?  765  LEU   C CD2   1 
ATOM   4474 N N     . GLN   A 1 766  ? 171.031 82.863  147.624 1.00 42.90  ?  766  GLN   C N     1 
ATOM   4475 C CA    . GLN   A 1 766  ? 171.598 81.749  146.876 1.00 43.67  ?  766  GLN   C CA    1 
ATOM   4476 C C     . GLN   A 1 766  ? 172.926 81.317  147.470 1.00 45.06  ?  766  GLN   C C     1 
ATOM   4477 O O     . GLN   A 1 766  ? 173.544 80.362  147.001 1.00 45.90  ?  766  GLN   C O     1 
ATOM   4478 C CB    . GLN   A 1 766  ? 171.777 82.099  145.402 1.00 43.06  ?  766  GLN   C CB    1 
ATOM   4479 C CG    . GLN   A 1 766  ? 170.481 82.244  144.643 1.00 43.50  ?  766  GLN   C CG    1 
ATOM   4480 C CD    . GLN   A 1 766  ? 170.709 82.615  143.200 1.00 49.03  ?  766  GLN   C CD    1 
ATOM   4481 O OE1   . GLN   A 1 766  ? 171.687 83.295  142.877 1.00 49.25  ?  766  GLN   C OE1   1 
ATOM   4482 N NE2   . GLN   A 1 766  ? 169.824 82.168  142.315 1.00 48.37  ?  766  GLN   C NE2   1 
ATOM   4483 N N     . HIS   A 1 767  ? 173.369 82.026  148.499 1.00 44.23  ?  767  HIS   C N     1 
ATOM   4484 C CA    . HIS   A 1 767  ? 174.621 81.702  149.156 1.00 46.72  ?  767  HIS   C CA    1 
ATOM   4485 C C     . HIS   A 1 767  ? 174.480 80.338  149.840 1.00 47.55  ?  767  HIS   C C     1 
ATOM   4486 O O     . HIS   A 1 767  ? 173.470 80.091  150.503 1.00 49.38  ?  767  HIS   C O     1 
ATOM   4487 C CB    . HIS   A 1 767  ? 174.956 82.795  150.183 1.00 51.81  ?  767  HIS   C CB    1 
ATOM   4488 C CG    . HIS   A 1 767  ? 176.343 82.754  150.746 1.00 56.05  ?  767  HIS   C CG    1 
ATOM   4489 N ND1   . HIS   A 1 767  ? 176.754 81.800  151.648 1.00 55.47  ?  767  HIS   C ND1   1 
ATOM   4490 C CD2   . HIS   A 1 767  ? 177.407 83.567  150.544 1.00 55.54  ?  767  HIS   C CD2   1 
ATOM   4491 C CE1   . HIS   A 1 767  ? 178.016 82.026  151.977 1.00 57.22  ?  767  HIS   C CE1   1 
ATOM   4492 N NE2   . HIS   A 1 767  ? 178.433 83.091  151.317 1.00 56.03  ?  767  HIS   C NE2   1 
ATOM   4493 N N     . PRO   A 1 768  ? 175.469 79.442  149.722 1.00 48.24  ?  768  PRO   C N     1 
ATOM   4494 C CA    . PRO   A 1 768  ? 175.477 78.101  150.283 1.00 50.97  ?  768  PRO   C CA    1 
ATOM   4495 C C     . PRO   A 1 768  ? 175.339 78.092  151.802 1.00 53.32  ?  768  PRO   C C     1 
ATOM   4496 O O     . PRO   A 1 768  ? 174.917 77.094  152.383 1.00 53.32  ?  768  PRO   C O     1 
ATOM   4497 C CB    . PRO   A 1 768  ? 176.842 77.554  149.837 1.00 48.92  ?  768  PRO   C CB    1 
ATOM   4498 C CG    . PRO   A 1 768  ? 177.666 78.774  149.487 1.00 49.16  ?  768  PRO   C CG    1 
ATOM   4499 C CD    . PRO   A 1 768  ? 176.676 79.773  148.952 1.00 46.99  ?  768  PRO   C CD    1 
ATOM   4500 N N     . GLY   A 1 769  ? 175.703 79.201  152.439 1.00 52.65  ?  769  GLY   C N     1 
ATOM   4501 C CA    . GLY   A 1 769  ? 175.645 79.317  153.889 1.00 52.93  ?  769  GLY   C CA    1 
ATOM   4502 C C     . GLY   A 1 769  ? 174.440 80.123  154.361 1.00 50.46  ?  769  GLY   C C     1 
ATOM   4503 O O     . GLY   A 1 769  ? 174.396 80.551  155.512 1.00 50.19  ?  769  GLY   C O     1 
ATOM   4504 N N     . CYS   A 1 770  ? 173.481 80.360  153.469 1.00 47.18  ?  770  CYS   C N     1 
ATOM   4505 C CA    . CYS   A 1 770  ? 172.319 81.184  153.790 1.00 45.51  ?  770  CYS   C CA    1 
ATOM   4506 C C     . CYS   A 1 770  ? 171.596 80.727  155.056 1.00 40.28  ?  770  CYS   C C     1 
ATOM   4507 O O     . CYS   A 1 770  ? 171.442 81.495  156.002 1.00 41.66  ?  770  CYS   C O     1 
ATOM   4508 C CB    . CYS   A 1 770  ? 171.338 81.177  152.623 1.00 49.39  ?  770  CYS   C CB    1 
ATOM   4509 S SG    . CYS   A 1 770  ? 169.811 82.053  152.949 1.00 52.06  ?  770  CYS   C SG    1 
ATOM   4510 N N     . ASN   A 1 771  ? 171.140 79.479  155.057 1.00 38.64  ?  771  ASN   C N     1 
ATOM   4511 C CA    . ASN   A 1 771  ? 170.504 78.847  156.219 1.00 39.11  ?  771  ASN   C CA    1 
ATOM   4512 C C     . ASN   A 1 771  ? 169.185 79.483  156.666 1.00 33.79  ?  771  ASN   C C     1 
ATOM   4513 O O     . ASN   A 1 771  ? 168.672 79.145  157.732 1.00 32.06  ?  771  ASN   C O     1 
ATOM   4514 C CB    . ASN   A 1 771  ? 171.475 78.818  157.384 1.00 40.56  ?  771  ASN   C CB    1 
ATOM   4515 C CG    . ASN   A 1 771  ? 172.741 78.113  157.035 1.00 48.10  ?  771  ASN   C CG    1 
ATOM   4516 O OD1   . ASN   A 1 771  ? 172.717 77.043  156.411 1.00 48.71  ?  771  ASN   C OD1   1 
ATOM   4517 N ND2   . ASN   A 1 771  ? 173.852 78.683  157.411 1.00 49.21  ?  771  ASN   C ND2   1 
ATOM   4518 N N     . ILE   A 1 772  ? 168.611 80.354  155.850 1.00 29.05  ?  772  ILE   C N     1 
ATOM   4519 C CA    . ILE   A 1 772  ? 167.324 80.959  156.179 1.00 26.29  ?  772  ILE   C CA    1 
ATOM   4520 C C     . ILE   A 1 772  ? 166.184 80.018  155.827 1.00 28.91  ?  772  ILE   C C     1 
ATOM   4521 O O     . ILE   A 1 772  ? 166.173 79.428  154.749 1.00 33.42  ?  772  ILE   C O     1 
ATOM   4522 C CB    . ILE   A 1 772  ? 167.138 82.314  155.471 1.00 24.75  ?  772  ILE   C CB    1 
ATOM   4523 C CG1   . ILE   A 1 772  ? 168.188 83.299  156.000 1.00 30.03  ?  772  ILE   C CG1   1 
ATOM   4524 C CG2   . ILE   A 1 772  ? 165.720 82.847  155.694 1.00 24.01  ?  772  ILE   C CG2   1 
ATOM   4525 C CD1   . ILE   A 1 772  ? 168.281 84.589  155.223 1.00 35.47  ?  772  ILE   C CD1   1 
ATOM   4526 N N     . ARG   A 1 773  ? 165.239 79.860  156.750 1.00 25.18  ?  773  ARG   C N     1 
ATOM   4527 C CA    . ARG   A 1 773  ? 164.115 78.962  156.537 1.00 21.49  ?  773  ARG   C CA    1 
ATOM   4528 C C     . ARG   A 1 773  ? 162.852 79.702  156.134 1.00 19.01  ?  773  ARG   C C     1 
ATOM   4529 O O     . ARG   A 1 773  ? 162.073 79.211  155.315 1.00 24.03  ?  773  ARG   C O     1 
ATOM   4530 C CB    . ARG   A 1 773  ? 163.821 78.173  157.795 1.00 23.61  ?  773  ARG   C CB    1 
ATOM   4531 C CG    . ARG   A 1 773  ? 164.928 77.259  158.261 1.00 29.26  ?  773  ARG   C CG    1 
ATOM   4532 C CD    . ARG   A 1 773  ? 165.130 76.139  157.338 1.00 32.86  ?  773  ARG   C CD    1 
ATOM   4533 N NE    . ARG   A 1 773  ? 166.006 75.137  157.897 1.00 38.18  ?  773  ARG   C NE    1 
ATOM   4534 C CZ    . ARG   A 1 773  ? 166.309 73.974  157.301 1.00 47.98  ?  773  ARG   C CZ    1 
ATOM   4535 N NH1   . ARG   A 1 773  ? 165.793 73.684  156.126 1.00 47.72  1  773  ARG   C NH1   1 
ATOM   4536 N NH2   . ARG   A 1 773  ? 167.120 73.119  157.901 1.00 47.01  ?  773  ARG   C NH2   1 
ATOM   4537 N N     . ARG   A 1 774  ? 162.621 80.866  156.721 1.00 15.97  ?  774  ARG   C N     1 
ATOM   4538 C CA    . ARG   A 1 774  ? 161.391 81.581  156.433 1.00 11.68  ?  774  ARG   C CA    1 
ATOM   4539 C C     . ARG   A 1 774  ? 161.657 82.969  155.876 1.00 9.65   ?  774  ARG   C C     1 
ATOM   4540 O O     . ARG   A 1 774  ? 162.288 83.802  156.530 1.00 17.39  ?  774  ARG   C O     1 
ATOM   4541 C CB    . ARG   A 1 774  ? 160.546 81.684  157.689 1.00 19.45  ?  774  ARG   C CB    1 
ATOM   4542 C CG    . ARG   A 1 774  ? 160.174 80.342  158.312 1.00 23.39  ?  774  ARG   C CG    1 
ATOM   4543 C CD    . ARG   A 1 774  ? 159.197 80.485  159.425 1.00 24.74  ?  774  ARG   C CD    1 
ATOM   4544 N NE    . ARG   A 1 774  ? 158.750 79.195  159.930 1.00 29.75  ?  774  ARG   C NE    1 
ATOM   4545 C CZ    . ARG   A 1 774  ? 159.384 78.460  160.863 1.00 36.75  ?  774  ARG   C CZ    1 
ATOM   4546 N NH1   . ARG   A 1 774  ? 160.504 78.889  161.397 1.00 33.59  1  774  ARG   C NH1   1 
ATOM   4547 N NH2   . ARG   A 1 774  ? 158.872 77.300  161.241 1.00 43.10  ?  774  ARG   C NH2   1 
ATOM   4548 N N     . LEU   A 1 775  ? 161.169 83.222  154.667 1.00 3.41   ?  775  LEU   C N     1 
ATOM   4549 C CA    . LEU   A 1 775  ? 161.324 84.527  154.039 1.00 0.00   ?  775  LEU   C CA    1 
ATOM   4550 C C     . LEU   A 1 775  ? 159.996 85.262  153.973 1.00 0.01   ?  775  LEU   C C     1 
ATOM   4551 O O     . LEU   A 1 775  ? 159.201 85.061  153.050 1.00 0.00   ?  775  LEU   C O     1 
ATOM   4552 C CB    . LEU   A 1 775  ? 161.906 84.368  152.636 1.00 0.01   ?  775  LEU   C CB    1 
ATOM   4553 C CG    . LEU   A 1 775  ? 161.999 85.637  151.794 1.00 0.37   ?  775  LEU   C CG    1 
ATOM   4554 C CD1   . LEU   A 1 775  ? 162.855 86.676  152.496 1.00 12.45  ?  775  LEU   C CD1   1 
ATOM   4555 C CD2   . LEU   A 1 775  ? 162.595 85.279  150.459 1.00 14.60  ?  775  LEU   C CD2   1 
ATOM   4556 N N     . TRP   A 1 776  ? 159.748 86.106  154.959 1.00 0.08   ?  776  TRP   C N     1 
ATOM   4557 C CA    . TRP   A 1 776  ? 158.463 86.773  155.073 1.00 0.08   ?  776  TRP   C CA    1 
ATOM   4558 C C     . TRP   A 1 776  ? 158.465 88.147  154.425 1.00 0.01   ?  776  TRP   C C     1 
ATOM   4559 O O     . TRP   A 1 776  ? 158.496 89.167  155.113 1.00 0.31   ?  776  TRP   C O     1 
ATOM   4560 C CB    . TRP   A 1 776  ? 158.054 86.892  156.538 1.00 7.04   ?  776  TRP   C CB    1 
ATOM   4561 C CG    . TRP   A 1 776  ? 157.730 85.582  157.191 1.00 9.35   ?  776  TRP   C CG    1 
ATOM   4562 C CD1   . TRP   A 1 776  ? 157.477 84.386  156.585 1.00 13.01  ?  776  TRP   C CD1   1 
ATOM   4563 C CD2   . TRP   A 1 776  ? 157.630 85.339  158.606 1.00 16.48  ?  776  TRP   C CD2   1 
ATOM   4564 N NE1   . TRP   A 1 776  ? 157.221 83.424  157.531 1.00 16.43  ?  776  TRP   C NE1   1 
ATOM   4565 C CE2   . TRP   A 1 776  ? 157.317 83.988  158.769 1.00 18.19  ?  776  TRP   C CE2   1 
ATOM   4566 C CE3   . TRP   A 1 776  ? 157.787 86.145  159.735 1.00 24.76  ?  776  TRP   C CE3   1 
ATOM   4567 C CZ2   . TRP   A 1 776  ? 157.151 83.424  160.018 1.00 27.91  ?  776  TRP   C CZ2   1 
ATOM   4568 C CZ3   . TRP   A 1 776  ? 157.621 85.578  160.987 1.00 28.58  ?  776  TRP   C CZ3   1 
ATOM   4569 C CH2   . TRP   A 1 776  ? 157.313 84.252  161.124 1.00 32.05  ?  776  TRP   C CH2   1 
ATOM   4570 N N     . LEU   A 1 777  ? 158.419 88.172  153.104 1.00 0.00   ?  777  LEU   C N     1 
ATOM   4571 C CA    . LEU   A 1 777  ? 158.318 89.432  152.381 1.00 0.00   ?  777  LEU   C CA    1 
ATOM   4572 C C     . LEU   A 1 777  ? 156.922 90.000  152.583 1.00 0.10   ?  777  LEU   C C     1 
ATOM   4573 O O     . LEU   A 1 777  ? 155.957 89.254  152.719 1.00 0.00   ?  777  LEU   C O     1 
ATOM   4574 C CB    . LEU   A 1 777  ? 158.602 89.220  150.891 1.00 0.00   ?  777  LEU   C CB    1 
ATOM   4575 C CG    . LEU   A 1 777  ? 160.026 88.797  150.541 1.00 1.50   ?  777  LEU   C CG    1 
ATOM   4576 C CD1   . LEU   A 1 777  ? 160.058 88.264  149.132 1.00 14.88  ?  777  LEU   C CD1   1 
ATOM   4577 C CD2   . LEU   A 1 777  ? 160.952 89.982  150.660 1.00 16.37  ?  777  LEU   C CD2   1 
ATOM   4578 N N     . GLY   A 1 778  ? 156.812 91.315  152.639 1.00 11.12  ?  778  GLY   C N     1 
ATOM   4579 C CA    . GLY   A 1 778  ? 155.514 91.953  152.815 1.00 14.53  ?  778  GLY   C CA    1 
ATOM   4580 C C     . GLY   A 1 778  ? 155.218 92.880  151.657 1.00 13.06  ?  778  GLY   C C     1 
ATOM   4581 O O     . GLY   A 1 778  ? 155.516 92.563  150.508 1.00 16.75  ?  778  GLY   C O     1 
ATOM   4582 N N     . ARG   A 1 779  ? 154.658 94.046  151.963 1.00 14.46  ?  779  ARG   C N     1 
ATOM   4583 C CA    . ARG   A 1 779  ? 154.319 95.026  150.939 1.00 15.17  ?  779  ARG   C CA    1 
ATOM   4584 C C     . ARG   A 1 779  ? 155.578 95.655  150.368 1.00 18.07  ?  779  ARG   C C     1 
ATOM   4585 O O     . ARG   A 1 779  ? 155.855 96.831  150.591 1.00 22.96  ?  779  ARG   C O     1 
ATOM   4586 C CB    . ARG   A 1 779  ? 153.452 96.129  151.524 1.00 17.19  ?  779  ARG   C CB    1 
ATOM   4587 C CG    . ARG   A 1 779  ? 152.098 95.688  151.971 1.00 18.34  ?  779  ARG   C CG    1 
ATOM   4588 C CD    . ARG   A 1 779  ? 151.342 96.759  152.630 1.00 21.54  ?  779  ARG   C CD    1 
ATOM   4589 N NE    . ARG   A 1 779  ? 150.018 96.298  153.000 1.00 28.93  ?  779  ARG   C NE    1 
ATOM   4590 C CZ    . ARG   A 1 779  ? 149.067 97.057  153.576 1.00 38.10  ?  779  ARG   C CZ    1 
ATOM   4591 N NH1   . ARG   A 1 779  ? 149.303 98.325  153.851 1.00 35.20  1  779  ARG   C NH1   1 
ATOM   4592 N NH2   . ARG   A 1 779  ? 147.894 96.523  153.861 1.00 35.13  ?  779  ARG   C NH2   1 
ATOM   4593 N N     . CYS   A 1 780  ? 156.339 94.854  149.637 1.00 16.43  ?  780  CYS   C N     1 
ATOM   4594 C CA    . CYS   A 1 780  ? 157.625 95.255  149.095 1.00 18.83  ?  780  CYS   C CA    1 
ATOM   4595 C C     . CYS   A 1 780  ? 157.495 95.934  147.743 1.00 20.77  ?  780  CYS   C C     1 
ATOM   4596 O O     . CYS   A 1 780  ? 158.465 96.478  147.219 1.00 27.71  ?  780  CYS   C O     1 
ATOM   4597 C CB    . CYS   A 1 780  ? 158.522 94.033  148.952 1.00 21.26  ?  780  CYS   C CB    1 
ATOM   4598 S SG    . CYS   A 1 780  ? 158.953 93.247  150.510 1.00 31.54  ?  780  CYS   C SG    1 
ATOM   4599 N N     . GLY   A 1 781  ? 156.300 95.901  147.174 1.00 18.35  ?  781  GLY   C N     1 
ATOM   4600 C CA    . GLY   A 1 781  ? 156.084 96.492  145.864 1.00 20.25  ?  781  GLY   C CA    1 
ATOM   4601 C C     . GLY   A 1 781  ? 156.689 95.625  144.772 1.00 20.99  ?  781  GLY   C C     1 
ATOM   4602 O O     . GLY   A 1 781  ? 157.178 96.134  143.764 1.00 24.43  ?  781  GLY   C O     1 
ATOM   4603 N N     . LEU   A 1 782  ? 156.673 94.315  144.978 1.00 18.46  ?  782  LEU   C N     1 
ATOM   4604 C CA    . LEU   A 1 782  ? 157.268 93.411  144.011 1.00 18.84  ?  782  LEU   C CA    1 
ATOM   4605 C C     . LEU   A 1 782  ? 156.503 93.520  142.707 1.00 20.20  ?  782  LEU   C C     1 
ATOM   4606 O O     . LEU   A 1 782  ? 155.271 93.585  142.705 1.00 23.21  ?  782  LEU   C O     1 
ATOM   4607 C CB    . LEU   A 1 782  ? 157.215 91.961  144.510 1.00 17.85  ?  782  LEU   C CB    1 
ATOM   4608 C CG    . LEU   A 1 782  ? 157.915 91.659  145.831 1.00 18.67  ?  782  LEU   C CG    1 
ATOM   4609 C CD1   . LEU   A 1 782  ? 157.638 90.217  146.205 1.00 19.53  ?  782  LEU   C CD1   1 
ATOM   4610 C CD2   . LEU   A 1 782  ? 159.401 91.916  145.712 1.00 24.43  ?  782  LEU   C CD2   1 
ATOM   4611 N N     . SER   A 1 783  ? 157.231 93.547  141.600 1.00 22.40  ?  783  SER   C N     1 
ATOM   4612 C CA    . SER   A 1 783  ? 156.619 93.662  140.289 1.00 25.77  ?  783  SER   C CA    1 
ATOM   4613 C C     . SER   A 1 783  ? 156.688 92.376  139.488 1.00 28.22  ?  783  SER   C C     1 
ATOM   4614 O O     . SER   A 1 783  ? 157.020 91.309  140.006 1.00 28.72  ?  783  SER   C O     1 
ATOM   4615 C CB    . SER   A 1 783  ? 157.284 94.767  139.502 1.00 41.38  ?  783  SER   C CB    1 
ATOM   4616 O OG    . SER   A 1 783  ? 156.607 95.000  138.295 1.00 45.55  ?  783  SER   C OG    1 
ATOM   4617 N N     . HIS   A 1 784  ? 156.376 92.496  138.208 1.00 26.85  ?  784  HIS   C N     1 
ATOM   4618 C CA    . HIS   A 1 784  ? 156.317 91.362  137.306 1.00 25.04  ?  784  HIS   C CA    1 
ATOM   4619 C C     . HIS   A 1 784  ? 157.675 90.738  137.042 1.00 29.60  ?  784  HIS   C C     1 
ATOM   4620 O O     . HIS   A 1 784  ? 157.799 89.516  136.978 1.00 33.88  ?  784  HIS   C O     1 
ATOM   4621 C CB    . HIS   A 1 784  ? 155.722 91.805  135.970 1.00 26.78  ?  784  HIS   C CB    1 
ATOM   4622 C CG    . HIS   A 1 784  ? 154.278 92.110  136.032 1.00 31.78  ?  784  HIS   C CG    1 
ATOM   4623 N ND1   . HIS   A 1 784  ? 153.611 92.757  135.015 1.00 39.30  ?  784  HIS   C ND1   1 
ATOM   4624 C CD2   . HIS   A 1 784  ? 153.361 91.862  136.986 1.00 37.74  ?  784  HIS   C CD2   1 
ATOM   4625 C CE1   . HIS   A 1 784  ? 152.339 92.890  135.344 1.00 41.73  ?  784  HIS   C CE1   1 
ATOM   4626 N NE2   . HIS   A 1 784  ? 152.159 92.355  136.537 1.00 42.47  ?  784  HIS   C NE2   1 
ATOM   4627 N N     . GLU   A 1 785  ? 158.692 91.575  136.877 1.00 32.61  ?  785  GLU   C N     1 
ATOM   4628 C CA    . GLU   A 1 785  ? 160.012 91.083  136.504 1.00 35.83  ?  785  GLU   C CA    1 
ATOM   4629 C C     . GLU   A 1 785  ? 160.806 90.541  137.683 1.00 39.19  ?  785  GLU   C C     1 
ATOM   4630 O O     . GLU   A 1 785  ? 161.542 89.567  137.544 1.00 40.37  ?  785  GLU   C O     1 
ATOM   4631 C CB    . GLU   A 1 785  ? 160.813 92.190  135.816 1.00 38.11  ?  785  GLU   C CB    1 
ATOM   4632 C CG    . GLU   A 1 785  ? 160.284 92.601  134.450 1.00 32.51  ?  785  GLU   C CG    1 
ATOM   4633 C CD    . GLU   A 1 785  ? 160.413 91.516  133.421 1.00 27.43  ?  785  GLU   C CD    1 
ATOM   4634 O OE1   . GLU   A 1 785  ? 161.419 90.854  133.408 1.00 26.24  ?  785  GLU   C OE1   1 
ATOM   4635 O OE2   . GLU   A 1 785  ? 159.504 91.351  132.646 1.00 32.30  -1 785  GLU   C OE2   1 
ATOM   4636 N N     . CYS   A 1 786  ? 160.663 91.161  138.848 1.00 34.73  ?  786  CYS   C N     1 
ATOM   4637 C CA    . CYS   A 1 786  ? 161.482 90.786  139.997 1.00 34.15  ?  786  CYS   C CA    1 
ATOM   4638 C C     . CYS   A 1 786  ? 161.135 89.394  140.499 1.00 35.12  ?  786  CYS   C C     1 
ATOM   4639 O O     . CYS   A 1 786  ? 161.929 88.757  141.193 1.00 35.37  ?  786  CYS   C O     1 
ATOM   4640 C CB    . CYS   A 1 786  ? 161.292 91.763  141.139 1.00 36.20  ?  786  CYS   C CB    1 
ATOM   4641 S SG    . CYS   A 1 786  ? 159.728 91.584  141.951 1.00 39.90  ?  786  CYS   C SG    1 
ATOM   4642 N N     . CYS   A 1 787  ? 159.946 88.923  140.148 1.00 34.42  ?  787  CYS   C N     1 
ATOM   4643 C CA    . CYS   A 1 787  ? 159.504 87.603  140.558 1.00 31.24  ?  787  CYS   C CA    1 
ATOM   4644 C C     . CYS   A 1 787  ? 160.387 86.531  139.941 1.00 32.32  ?  787  CYS   C C     1 
ATOM   4645 O O     . CYS   A 1 787  ? 160.473 85.413  140.454 1.00 32.55  ?  787  CYS   C O     1 
ATOM   4646 C CB    . CYS   A 1 787  ? 158.062 87.353  140.160 1.00 29.69  ?  787  CYS   C CB    1 
ATOM   4647 S SG    . CYS   A 1 787  ? 157.390 85.856  140.895 1.00 36.67  ?  787  CYS   C SG    1 
ATOM   4648 N N     . PHE   A 1 788  ? 161.031 86.869  138.829 1.00 33.23  ?  788  PHE   C N     1 
ATOM   4649 C CA    . PHE   A 1 788  ? 161.945 85.962  138.163 1.00 33.08  ?  788  PHE   C CA    1 
ATOM   4650 C C     . PHE   A 1 788  ? 163.072 85.598  139.110 1.00 38.84  ?  788  PHE   C C     1 
ATOM   4651 O O     . PHE   A 1 788  ? 163.429 84.430  139.257 1.00 39.88  ?  788  PHE   C O     1 
ATOM   4652 C CB    . PHE   A 1 788  ? 162.513 86.612  136.907 1.00 28.15  ?  788  PHE   C CB    1 
ATOM   4653 C CG    . PHE   A 1 788  ? 163.503 85.783  136.201 1.00 25.18  ?  788  PHE   C CG    1 
ATOM   4654 C CD1   . PHE   A 1 788  ? 163.107 84.686  135.473 1.00 26.73  ?  788  PHE   C CD1   1 
ATOM   4655 C CD2   . PHE   A 1 788  ? 164.842 86.099  136.253 1.00 29.54  ?  788  PHE   C CD2   1 
ATOM   4656 C CE1   . PHE   A 1 788  ? 164.028 83.916  134.809 1.00 30.90  ?  788  PHE   C CE1   1 
ATOM   4657 C CE2   . PHE   A 1 788  ? 165.766 85.336  135.589 1.00 33.68  ?  788  PHE   C CE2   1 
ATOM   4658 C CZ    . PHE   A 1 788  ? 165.361 84.241  134.866 1.00 31.96  ?  788  PHE   C CZ    1 
ATOM   4659 N N     . ASP   A 1 789  ? 163.627 86.616  139.757 1.00 39.84  ?  789  ASP   C N     1 
ATOM   4660 C CA    . ASP   A 1 789  ? 164.740 86.430  140.668 1.00 39.38  ?  789  ASP   C CA    1 
ATOM   4661 C C     . ASP   A 1 789  ? 164.324 85.606  141.876 1.00 42.14  ?  789  ASP   C C     1 
ATOM   4662 O O     . ASP   A 1 789  ? 165.117 84.826  142.401 1.00 43.10  ?  789  ASP   C O     1 
ATOM   4663 C CB    . ASP   A 1 789  ? 165.284 87.789  141.099 1.00 41.02  ?  789  ASP   C CB    1 
ATOM   4664 C CG    . ASP   A 1 789  ? 166.031 88.502  139.980 1.00 54.36  ?  789  ASP   C CG    1 
ATOM   4665 O OD1   . ASP   A 1 789  ? 166.599 87.835  139.148 1.00 49.63  ?  789  ASP   C OD1   1 
ATOM   4666 O OD2   . ASP   A 1 789  ? 165.996 89.710  139.942 1.00 54.82  -1 789  ASP   C OD2   1 
ATOM   4667 N N     . ILE   A 1 790  ? 163.070 85.750  142.302 1.00 39.74  ?  790  ILE   C N     1 
ATOM   4668 C CA    . ILE   A 1 790  ? 162.573 84.935  143.409 1.00 35.33  ?  790  ILE   C CA    1 
ATOM   4669 C C     . ILE   A 1 790  ? 162.552 83.468  143.003 1.00 35.01  ?  790  ILE   C C     1 
ATOM   4670 O O     . ILE   A 1 790  ? 162.974 82.595  143.764 1.00 37.50  ?  790  ILE   C O     1 
ATOM   4671 C CB    . ILE   A 1 790  ? 161.167 85.368  143.871 1.00 32.02  ?  790  ILE   C CB    1 
ATOM   4672 C CG1   . ILE   A 1 790  ? 161.241 86.755  144.520 1.00 35.30  ?  790  ILE   C CG1   1 
ATOM   4673 C CG2   . ILE   A 1 790  ? 160.600 84.338  144.854 1.00 25.82  ?  790  ILE   C CG2   1 
ATOM   4674 C CD1   . ILE   A 1 790  ? 159.896 87.404  144.773 1.00 30.03  ?  790  ILE   C CD1   1 
ATOM   4675 N N     . SER   A 1 791  ? 162.087 83.200  141.788 1.00 33.29  ?  791  SER   C N     1 
ATOM   4676 C CA    . SER   A 1 791  ? 162.042 81.837  141.273 1.00 34.26  ?  791  SER   C CA    1 
ATOM   4677 C C     . SER   A 1 791  ? 163.425 81.189  141.288 1.00 36.66  ?  791  SER   C C     1 
ATOM   4678 O O     . SER   A 1 791  ? 163.554 79.995  141.575 1.00 37.20  ?  791  SER   C O     1 
ATOM   4679 C CB    . SER   A 1 791  ? 161.489 81.827  139.866 1.00 37.00  ?  791  SER   C CB    1 
ATOM   4680 O OG    . SER   A 1 791  ? 161.403 80.521  139.377 1.00 40.37  ?  791  SER   C OG    1 
ATOM   4681 N N     . LEU   A 1 792  ? 164.457 81.982  140.999 1.00 37.95  ?  792  LEU   C N     1 
ATOM   4682 C CA    . LEU   A 1 792  ? 165.831 81.486  140.969 1.00 41.07  ?  792  LEU   C CA    1 
ATOM   4683 C C     . LEU   A 1 792  ? 166.342 81.120  142.360 1.00 41.22  ?  792  LEU   C C     1 
ATOM   4684 O O     . LEU   A 1 792  ? 167.375 80.462  142.497 1.00 41.66  ?  792  LEU   C O     1 
ATOM   4685 C CB    . LEU   A 1 792  ? 166.775 82.537  140.375 1.00 43.03  ?  792  LEU   C CB    1 
ATOM   4686 C CG    . LEU   A 1 792  ? 166.552 82.938  138.910 1.00 44.66  ?  792  LEU   C CG    1 
ATOM   4687 C CD1   . LEU   A 1 792  ? 167.509 84.071  138.573 1.00 45.45  ?  792  LEU   C CD1   1 
ATOM   4688 C CD2   . LEU   A 1 792  ? 166.782 81.748  137.992 1.00 44.73  ?  792  LEU   C CD2   1 
ATOM   4689 N N     . VAL   A 1 793  ? 165.640 81.561  143.396 1.00 38.35  ?  793  VAL   C N     1 
ATOM   4690 C CA    . VAL   A 1 793  ? 166.016 81.206  144.752 1.00 36.68  ?  793  VAL   C CA    1 
ATOM   4691 C C     . VAL   A 1 793  ? 165.382 79.872  145.090 1.00 38.77  ?  793  VAL   C C     1 
ATOM   4692 O O     . VAL   A 1 793  ? 166.033 78.978  145.622 1.00 39.05  ?  793  VAL   C O     1 
ATOM   4693 C CB    . VAL   A 1 793  ? 165.562 82.275  145.763 1.00 34.22  ?  793  VAL   C CB    1 
ATOM   4694 C CG1   . VAL   A 1 793  ? 165.859 81.810  147.188 1.00 38.60  ?  793  VAL   C CG1   1 
ATOM   4695 C CG2   . VAL   A 1 793  ? 166.278 83.585  145.474 1.00 41.31  ?  793  VAL   C CG2   1 
ATOM   4696 N N     . LEU   A 1 794  ? 164.105 79.735  144.760 1.00 38.01  ?  794  LEU   C N     1 
ATOM   4697 C CA    . LEU   A 1 794  ? 163.357 78.521  145.066 1.00 33.36  ?  794  LEU   C CA    1 
ATOM   4698 C C     . LEU   A 1 794  ? 163.952 77.293  144.392 1.00 37.54  ?  794  LEU   C C     1 
ATOM   4699 O O     . LEU   A 1 794  ? 163.990 76.209  144.974 1.00 41.20  ?  794  LEU   C O     1 
ATOM   4700 C CB    . LEU   A 1 794  ? 161.908 78.682  144.603 1.00 31.05  ?  794  LEU   C CB    1 
ATOM   4701 C CG    . LEU   A 1 794  ? 161.044 79.661  145.391 1.00 27.50  ?  794  LEU   C CG    1 
ATOM   4702 C CD1   . LEU   A 1 794  ? 159.757 79.902  144.631 1.00 34.87  ?  794  LEU   C CD1   1 
ATOM   4703 C CD2   . LEU   A 1 794  ? 160.741 79.077  146.760 1.00 27.08  ?  794  LEU   C CD2   1 
ATOM   4704 N N     . SER   A 1 795  ? 164.437 77.467  143.170 1.00 37.63  ?  795  SER   C N     1 
ATOM   4705 C CA    . SER   A 1 795  ? 164.992 76.359  142.403 1.00 40.82  ?  795  SER   C CA    1 
ATOM   4706 C C     . SER   A 1 795  ? 166.409 75.975  142.830 1.00 41.74  ?  795  SER   C C     1 
ATOM   4707 O O     . SER   A 1 795  ? 166.949 74.978  142.350 1.00 43.82  ?  795  SER   C O     1 
ATOM   4708 C CB    . SER   A 1 795  ? 164.989 76.701  140.928 1.00 44.89  ?  795  SER   C CB    1 
ATOM   4709 O OG    . SER   A 1 795  ? 165.886 77.739  140.650 1.00 43.66  ?  795  SER   C OG    1 
ATOM   4710 N N     . SER   A 1 796  ? 167.026 76.774  143.699 1.00 40.77  ?  796  SER   C N     1 
ATOM   4711 C CA    . SER   A 1 796  ? 168.410 76.534  144.098 1.00 42.42  ?  796  SER   C CA    1 
ATOM   4712 C C     . SER   A 1 796  ? 168.550 76.313  145.602 1.00 43.36  ?  796  SER   C C     1 
ATOM   4713 O O     . SER   A 1 796  ? 169.222 75.378  146.042 1.00 43.13  ?  796  SER   C O     1 
ATOM   4714 C CB    . SER   A 1 796  ? 169.285 77.690  143.664 1.00 44.52  ?  796  SER   C CB    1 
ATOM   4715 O OG    . SER   A 1 796  ? 170.617 77.480  144.048 1.00 46.74  ?  796  SER   C OG    1 
ATOM   4716 N N     . ASN   A 1 797  ? 167.942 77.196  146.388 1.00 41.11  ?  797  ASN   C N     1 
ATOM   4717 C CA    . ASN   A 1 797  ? 168.027 77.144  147.840 1.00 39.81  ?  797  ASN   C CA    1 
ATOM   4718 C C     . ASN   A 1 797  ? 167.288 75.924  148.365 1.00 40.02  ?  797  ASN   C C     1 
ATOM   4719 O O     . ASN   A 1 797  ? 166.096 75.751  148.117 1.00 41.42  ?  797  ASN   C O     1 
ATOM   4720 C CB    . ASN   A 1 797  ? 167.477 78.423  148.448 1.00 39.66  ?  797  ASN   C CB    1 
ATOM   4721 C CG    . ASN   A 1 797  ? 167.633 78.483  149.939 1.00 41.83  ?  797  ASN   C CG    1 
ATOM   4722 O OD1   . ASN   A 1 797  ? 167.227 77.553  150.652 1.00 37.88  ?  797  ASN   C OD1   1 
ATOM   4723 N ND2   . ASN   A 1 797  ? 168.207 79.554  150.436 1.00 43.56  ?  797  ASN   C ND2   1 
ATOM   4724 N N     . GLN   A 1 798  ? 168.015 75.061  149.064 1.00 40.99  ?  798  GLN   C N     1 
ATOM   4725 C CA    . GLN   A 1 798  ? 167.487 73.782  149.518 1.00 43.59  ?  798  GLN   C CA    1 
ATOM   4726 C C     . GLN   A 1 798  ? 166.860 73.835  150.904 1.00 43.84  ?  798  GLN   C C     1 
ATOM   4727 O O     . GLN   A 1 798  ? 166.304 72.841  151.374 1.00 44.46  ?  798  GLN   C O     1 
ATOM   4728 C CB    . GLN   A 1 798  ? 168.613 72.745  149.528 1.00 45.86  ?  798  GLN   C CB    1 
ATOM   4729 C CG    . GLN   A 1 798  ? 169.243 72.510  148.175 1.00 49.09  ?  798  GLN   C CG    1 
ATOM   4730 C CD    . GLN   A 1 798  ? 168.253 71.967  147.200 1.00 56.21  ?  798  GLN   C CD    1 
ATOM   4731 O OE1   . GLN   A 1 798  ? 167.704 70.883  147.416 1.00 53.73  ?  798  GLN   C OE1   1 
ATOM   4732 N NE2   . GLN   A 1 798  ? 168.003 72.714  146.130 1.00 52.04  ?  798  GLN   C NE2   1 
ATOM   4733 N N     . LYS   A 1 799  ? 166.980 74.972  151.577 1.00 38.49  ?  799  LYS   C N     1 
ATOM   4734 C CA    . LYS   A 1 799  ? 166.541 75.060  152.963 1.00 36.69  ?  799  LYS   C CA    1 
ATOM   4735 C C     . LYS   A 1 799  ? 165.277 75.887  153.161 1.00 33.60  ?  799  LYS   C C     1 
ATOM   4736 O O     . LYS   A 1 799  ? 164.573 75.704  154.153 1.00 32.90  ?  799  LYS   C O     1 
ATOM   4737 C CB    . LYS   A 1 799  ? 167.679 75.590  153.832 1.00 38.97  ?  799  LYS   C CB    1 
ATOM   4738 C CG    . LYS   A 1 799  ? 168.860 74.624  153.923 1.00 43.06  ?  799  LYS   C CG    1 
ATOM   4739 C CD    . LYS   A 1 799  ? 169.961 75.141  154.835 1.00 46.54  ?  799  LYS   C CD    1 
ATOM   4740 C CE    . LYS   A 1 799  ? 171.097 74.125  154.950 1.00 49.16  ?  799  LYS   C CE    1 
ATOM   4741 N NZ    . LYS   A 1 799  ? 172.197 74.607  155.834 1.00 50.63  1  799  LYS   C NZ    1 
ATOM   4742 N N     . LEU   A 1 800  ? 164.989 76.799  152.242 1.00 28.96  ?  800  LEU   C N     1 
ATOM   4743 C CA    . LEU   A 1 800  ? 163.833 77.676  152.400 1.00 22.54  ?  800  LEU   C CA    1 
ATOM   4744 C C     . LEU   A 1 800  ? 162.541 76.861  152.490 1.00 23.76  ?  800  LEU   C C     1 
ATOM   4745 O O     . LEU   A 1 800  ? 162.278 76.010  151.641 1.00 27.65  ?  800  LEU   C O     1 
ATOM   4746 C CB    . LEU   A 1 800  ? 163.757 78.662  151.223 1.00 20.19  ?  800  LEU   C CB    1 
ATOM   4747 C CG    . LEU   A 1 800  ? 162.679 79.774  151.314 1.00 16.62  ?  800  LEU   C CG    1 
ATOM   4748 C CD1   . LEU   A 1 800  ? 163.034 80.749  152.429 1.00 21.37  ?  800  LEU   C CD1   1 
ATOM   4749 C CD2   . LEU   A 1 800  ? 162.593 80.503  149.983 1.00 17.01  ?  800  LEU   C CD2   1 
ATOM   4750 N N     . VAL   A 1 801  ? 161.742 77.125  153.526 1.00 21.98  ?  801  VAL   C N     1 
ATOM   4751 C CA    . VAL   A 1 801  ? 160.496 76.403  153.777 1.00 18.37  ?  801  VAL   C CA    1 
ATOM   4752 C C     . VAL   A 1 801  ? 159.254 77.250  153.530 1.00 17.34  ?  801  VAL   C C     1 
ATOM   4753 O O     . VAL   A 1 801  ? 158.264 76.761  152.980 1.00 23.44  ?  801  VAL   C O     1 
ATOM   4754 C CB    . VAL   A 1 801  ? 160.455 75.884  155.225 1.00 18.28  ?  801  VAL   C CB    1 
ATOM   4755 C CG1   . VAL   A 1 801  ? 159.120 75.215  155.500 1.00 22.46  ?  801  VAL   C CG1   1 
ATOM   4756 C CG2   . VAL   A 1 801  ? 161.581 74.909  155.435 1.00 23.78  ?  801  VAL   C CG2   1 
ATOM   4757 N N     . GLU   A 1 802  ? 159.277 78.499  153.985 1.00 13.52  ?  802  GLU   C N     1 
ATOM   4758 C CA    . GLU   A 1 802  ? 158.101 79.353  153.849 1.00 0.12   ?  802  GLU   C CA    1 
ATOM   4759 C C     . GLU   A 1 802  ? 158.402 80.574  153.005 1.00 5.19   ?  802  GLU   C C     1 
ATOM   4760 O O     . GLU   A 1 802  ? 159.482 81.158  153.105 1.00 14.51  ?  802  GLU   C O     1 
ATOM   4761 C CB    . GLU   A 1 802  ? 157.602 79.824  155.212 1.00 15.81  ?  802  GLU   C CB    1 
ATOM   4762 C CG    . GLU   A 1 802  ? 157.276 78.726  156.192 1.00 24.50  ?  802  GLU   C CG    1 
ATOM   4763 C CD    . GLU   A 1 802  ? 156.679 79.259  157.470 1.00 33.69  ?  802  GLU   C CD    1 
ATOM   4764 O OE1   . GLU   A 1 802  ? 156.445 80.447  157.547 1.00 29.63  ?  802  GLU   C OE1   1 
ATOM   4765 O OE2   . GLU   A 1 802  ? 156.478 78.485  158.382 1.00 34.20  -1 802  GLU   C OE2   1 
ATOM   4766 N N     . LEU   A 1 803  ? 157.425 80.988  152.212 1.00 0.00   ?  803  LEU   C N     1 
ATOM   4767 C CA    . LEU   A 1 803  ? 157.551 82.198  151.415 1.00 0.00   ?  803  LEU   C CA    1 
ATOM   4768 C C     . LEU   A 1 803  ? 156.245 82.970  151.404 1.00 0.00   ?  803  LEU   C C     1 
ATOM   4769 O O     . LEU   A 1 803  ? 155.189 82.408  151.113 1.00 0.00   ?  803  LEU   C O     1 
ATOM   4770 C CB    . LEU   A 1 803  ? 157.946 81.839  149.981 1.00 0.00   ?  803  LEU   C CB    1 
ATOM   4771 C CG    . LEU   A 1 803  ? 158.098 82.998  149.002 1.00 0.06   ?  803  LEU   C CG    1 
ATOM   4772 C CD1   . LEU   A 1 803  ? 159.295 83.849  149.396 1.00 0.00   ?  803  LEU   C CD1   1 
ATOM   4773 C CD2   . LEU   A 1 803  ? 158.268 82.436  147.604 1.00 13.81  ?  803  LEU   C CD2   1 
ATOM   4774 N N     . ASP   A 1 804  ? 156.317 84.249  151.726 1.00 0.02   ?  804  ASP   C N     1 
ATOM   4775 C CA    . ASP   A 1 804  ? 155.123 85.082  151.747 1.00 0.03   ?  804  ASP   C CA    1 
ATOM   4776 C C     . ASP   A 1 804  ? 155.268 86.272  150.822 1.00 0.00   ?  804  ASP   C C     1 
ATOM   4777 O O     . ASP   A 1 804  ? 156.135 87.113  151.020 1.00 0.00   ?  804  ASP   C O     1 
ATOM   4778 C CB    . ASP   A 1 804  ? 154.805 85.549  153.169 1.00 0.00   ?  804  ASP   C CB    1 
ATOM   4779 C CG    . ASP   A 1 804  ? 153.491 86.315  153.258 1.00 0.00   ?  804  ASP   C CG    1 
ATOM   4780 O OD1   . ASP   A 1 804  ? 153.016 86.766  152.236 1.00 6.44   ?  804  ASP   C OD1   1 
ATOM   4781 O OD2   . ASP   A 1 804  ? 152.969 86.442  154.341 1.00 0.02   -1 804  ASP   C OD2   1 
ATOM   4782 N N     . LEU   A 1 805  ? 154.476 86.301  149.763 1.00 2.20   ?  805  LEU   C N     1 
ATOM   4783 C CA    . LEU   A 1 805  ? 154.581 87.362  148.777 1.00 0.38   ?  805  LEU   C CA    1 
ATOM   4784 C C     . LEU   A 1 805  ? 153.344 88.255  148.771 1.00 7.21   ?  805  LEU   C C     1 
ATOM   4785 O O     . LEU   A 1 805  ? 153.010 88.852  147.747 1.00 11.50  ?  805  LEU   C O     1 
ATOM   4786 C CB    . LEU   A 1 805  ? 154.785 86.759  147.391 1.00 0.01   ?  805  LEU   C CB    1 
ATOM   4787 C CG    . LEU   A 1 805  ? 155.978 85.804  147.239 1.00 6.84   ?  805  LEU   C CG    1 
ATOM   4788 C CD1   . LEU   A 1 805  ? 155.969 85.198  145.846 1.00 17.96  ?  805  LEU   C CD1   1 
ATOM   4789 C CD2   . LEU   A 1 805  ? 157.253 86.551  147.480 1.00 14.53  ?  805  LEU   C CD2   1 
ATOM   4790 N N     . SER   A 1 806  ? 152.659 88.336  149.905 1.00 6.64   ?  806  SER   C N     1 
ATOM   4791 C CA    . SER   A 1 806  ? 151.392 89.059  149.998 1.00 8.39   ?  806  SER   C CA    1 
ATOM   4792 C C     . SER   A 1 806  ? 151.487 90.541  149.659 1.00 10.77  ?  806  SER   C C     1 
ATOM   4793 O O     . SER   A 1 806  ? 152.518 91.183  149.846 1.00 15.33  ?  806  SER   C O     1 
ATOM   4794 C CB    . SER   A 1 806  ? 150.813 88.937  151.393 1.00 10.03  ?  806  SER   C CB    1 
ATOM   4795 O OG    . SER   A 1 806  ? 150.547 87.604  151.717 1.00 13.55  ?  806  SER   C OG    1 
ATOM   4796 N N     . ASP   A 1 807  ? 150.369 91.073  149.186 1.00 12.96  ?  807  ASP   C N     1 
ATOM   4797 C CA    . ASP   A 1 807  ? 150.192 92.486  148.870 1.00 13.28  ?  807  ASP   C CA    1 
ATOM   4798 C C     . ASP   A 1 807  ? 151.200 93.035  147.867 1.00 14.11  ?  807  ASP   C C     1 
ATOM   4799 O O     . ASP   A 1 807  ? 151.664 94.167  148.000 1.00 19.51  ?  807  ASP   C O     1 
ATOM   4800 C CB    . ASP   A 1 807  ? 150.250 93.336  150.135 1.00 16.73  ?  807  ASP   C CB    1 
ATOM   4801 C CG    . ASP   A 1 807  ? 149.131 93.057  151.133 1.00 21.85  ?  807  ASP   C CG    1 
ATOM   4802 O OD1   . ASP   A 1 807  ? 148.113 92.557  150.738 1.00 21.24  ?  807  ASP   C OD1   1 
ATOM   4803 O OD2   . ASP   A 1 807  ? 149.299 93.380  152.288 1.00 27.23  -1 807  ASP   C OD2   1 
ATOM   4804 N N     . ASN   A 1 808  ? 151.505 92.261  146.840 1.00 12.74  ?  808  ASN   C N     1 
ATOM   4805 C CA    . ASN   A 1 808  ? 152.383 92.732  145.784 1.00 11.52  ?  808  ASN   C CA    1 
ATOM   4806 C C     . ASN   A 1 808  ? 151.676 92.712  144.445 1.00 15.03  ?  808  ASN   C C     1 
ATOM   4807 O O     . ASN   A 1 808  ? 150.527 92.287  144.346 1.00 20.16  ?  808  ASN   C O     1 
ATOM   4808 C CB    . ASN   A 1 808  ? 153.628 91.901  145.731 1.00 15.88  ?  808  ASN   C CB    1 
ATOM   4809 C CG    . ASN   A 1 808  ? 154.464 92.108  146.921 1.00 19.00  ?  808  ASN   C CG    1 
ATOM   4810 O OD1   . ASN   A 1 808  ? 155.144 93.138  147.058 1.00 22.42  ?  808  ASN   C OD1   1 
ATOM   4811 N ND2   . ASN   A 1 808  ? 154.435 91.163  147.805 1.00 17.36  ?  808  ASN   C ND2   1 
ATOM   4812 N N     . ALA   A 1 809  ? 152.359 93.161  143.403 1.00 17.08  ?  809  ALA   C N     1 
ATOM   4813 C CA    . ALA   A 1 809  ? 151.766 93.184  142.076 1.00 18.00  ?  809  ALA   C CA    1 
ATOM   4814 C C     . ALA   A 1 809  ? 152.152 91.945  141.291 1.00 20.22  ?  809  ALA   C C     1 
ATOM   4815 O O     . ALA   A 1 809  ? 152.639 92.037  140.166 1.00 24.81  ?  809  ALA   C O     1 
ATOM   4816 C CB    . ALA   A 1 809  ? 152.199 94.435  141.329 1.00 23.86  ?  809  ALA   C CB    1 
ATOM   4817 N N     . LEU   A 1 810  ? 151.929 90.781  141.868 1.00 15.74  ?  810  LEU   C N     1 
ATOM   4818 C CA    . LEU   A 1 810  ? 152.277 89.557  141.172 1.00 14.74  ?  810  LEU   C CA    1 
ATOM   4819 C C     . LEU   A 1 810  ? 151.150 89.131  140.274 1.00 20.28  ?  810  LEU   C C     1 
ATOM   4820 O O     . LEU   A 1 810  ? 150.362 88.259  140.626 1.00 26.92  ?  810  LEU   C O     1 
ATOM   4821 C CB    . LEU   A 1 810  ? 152.593 88.435  142.151 1.00 14.73  ?  810  LEU   C CB    1 
ATOM   4822 C CG    . LEU   A 1 810  ? 153.772 88.659  143.058 1.00 14.06  ?  810  LEU   C CG    1 
ATOM   4823 C CD1   . LEU   A 1 810  ? 153.864 87.506  144.009 1.00 15.78  ?  810  LEU   C CD1   1 
ATOM   4824 C CD2   . LEU   A 1 810  ? 155.053 88.774  142.232 1.00 22.54  ?  810  LEU   C CD2   1 
ATOM   4825 N N     . GLY   A 1 811  ? 151.070 89.755  139.112 1.00 19.60  ?  811  GLY   C N     1 
ATOM   4826 C CA    . GLY   A 1 811  ? 149.974 89.487  138.203 1.00 21.35  ?  811  GLY   C CA    1 
ATOM   4827 C C     . GLY   A 1 811  ? 150.125 88.096  137.624 1.00 25.94  ?  811  GLY   C C     1 
ATOM   4828 O O     . GLY   A 1 811  ? 151.011 87.337  138.022 1.00 27.06  ?  811  GLY   C O     1 
ATOM   4829 N N     . ASP   A 1 812  ? 149.253 87.744  136.695 1.00 27.19  ?  812  ASP   C N     1 
ATOM   4830 C CA    . ASP   A 1 812  ? 149.272 86.400  136.145 1.00 30.98  ?  812  ASP   C CA    1 
ATOM   4831 C C     . ASP   A 1 812  ? 150.655 86.022  135.639 1.00 34.27  ?  812  ASP   C C     1 
ATOM   4832 O O     . ASP   A 1 812  ? 151.122 84.900  135.848 1.00 35.40  ?  812  ASP   C O     1 
ATOM   4833 C CB    . ASP   A 1 812  ? 148.254 86.292  135.013 1.00 36.59  ?  812  ASP   C CB    1 
ATOM   4834 C CG    . ASP   A 1 812  ? 148.457 87.373  133.960 1.00 43.36  ?  812  ASP   C CG    1 
ATOM   4835 O OD1   . ASP   A 1 812  ? 149.240 88.274  134.201 1.00 38.74  ?  812  ASP   C OD1   1 
ATOM   4836 O OD2   . ASP   A 1 812  ? 147.838 87.296  132.930 1.00 50.13  -1 812  ASP   C OD2   1 
ATOM   4837 N N     . PHE   A 1 813  ? 151.317 86.973  135.001 1.00 29.65  ?  813  PHE   C N     1 
ATOM   4838 C CA    . PHE   A 1 813  ? 152.661 86.760  134.495 1.00 29.41  ?  813  PHE   C CA    1 
ATOM   4839 C C     . PHE   A 1 813  ? 153.619 86.379  135.615 1.00 29.64  ?  813  PHE   C C     1 
ATOM   4840 O O     . PHE   A 1 813  ? 154.401 85.434  135.486 1.00 32.15  ?  813  PHE   C O     1 
ATOM   4841 C CB    . PHE   A 1 813  ? 153.170 88.010  133.793 1.00 28.62  ?  813  PHE   C CB    1 
ATOM   4842 C CG    . PHE   A 1 813  ? 154.569 87.883  133.339 1.00 23.89  ?  813  PHE   C CG    1 
ATOM   4843 C CD1   . PHE   A 1 813  ? 154.875 87.201  132.180 1.00 23.01  ?  813  PHE   C CD1   1 
ATOM   4844 C CD2   . PHE   A 1 813  ? 155.588 88.435  134.074 1.00 25.98  ?  813  PHE   C CD2   1 
ATOM   4845 C CE1   . PHE   A 1 813  ? 156.177 87.077  131.768 1.00 22.78  ?  813  PHE   C CE1   1 
ATOM   4846 C CE2   . PHE   A 1 813  ? 156.886 88.317  133.668 1.00 27.30  ?  813  PHE   C CE2   1 
ATOM   4847 C CZ    . PHE   A 1 813  ? 157.184 87.636  132.511 1.00 25.05  ?  813  PHE   C CZ    1 
ATOM   4848 N N     . GLY   A 1 814  ? 153.575 87.131  136.710 1.00 27.71  ?  814  GLY   C N     1 
ATOM   4849 C CA    . GLY   A 1 814  ? 154.481 86.890  137.822 1.00 30.34  ?  814  GLY   C CA    1 
ATOM   4850 C C     . GLY   A 1 814  ? 154.287 85.492  138.395 1.00 32.17  ?  814  GLY   C C     1 
ATOM   4851 O O     . GLY   A 1 814  ? 155.257 84.801  138.714 1.00 34.20  ?  814  GLY   C O     1 
ATOM   4852 N N     . ILE   A 1 815  ? 153.036 85.062  138.508 1.00 28.10  ?  815  ILE   C N     1 
ATOM   4853 C CA    . ILE   A 1 815  ? 152.769 83.742  139.052 1.00 25.52  ?  815  ILE   C CA    1 
ATOM   4854 C C     . ILE   A 1 815  ? 153.287 82.657  138.136 1.00 30.66  ?  815  ILE   C C     1 
ATOM   4855 O O     . ILE   A 1 815  ? 153.876 81.684  138.602 1.00 32.67  ?  815  ILE   C O     1 
ATOM   4856 C CB    . ILE   A 1 815  ? 151.280 83.526  139.328 1.00 23.48  ?  815  ILE   C CB    1 
ATOM   4857 C CG1   . ILE   A 1 815  ? 150.794 84.490  140.417 1.00 24.94  ?  815  ILE   C CG1   1 
ATOM   4858 C CG2   . ILE   A 1 815  ? 151.005 82.085  139.723 1.00 24.93  ?  815  ILE   C CG2   1 
ATOM   4859 C CD1   . ILE   A 1 815  ? 151.571 84.450  141.735 1.00 26.18  ?  815  ILE   C CD1   1 
ATOM   4860 N N     . ARG   A 1 816  ? 153.095 82.814  136.834 1.00 30.46  ?  816  ARG   C N     1 
ATOM   4861 C CA    . ARG   A 1 816  ? 153.616 81.818  135.916 1.00 29.83  ?  816  ARG   C CA    1 
ATOM   4862 C C     . ARG   A 1 816  ? 155.100 81.579  136.178 1.00 31.84  ?  816  ARG   C C     1 
ATOM   4863 O O     . ARG   A 1 816  ? 155.543 80.432  136.259 1.00 34.32  ?  816  ARG   C O     1 
ATOM   4864 C CB    . ARG   A 1 816  ? 153.412 82.247  134.477 1.00 26.91  ?  816  ARG   C CB    1 
ATOM   4865 C CG    . ARG   A 1 816  ? 153.876 81.239  133.447 1.00 28.13  ?  816  ARG   C CG    1 
ATOM   4866 C CD    . ARG   A 1 816  ? 153.722 81.755  132.078 1.00 30.44  ?  816  ARG   C CD    1 
ATOM   4867 N NE    . ARG   A 1 816  ? 152.327 81.909  131.719 1.00 37.67  ?  816  ARG   C NE    1 
ATOM   4868 C CZ    . ARG   A 1 816  ? 151.882 82.530  130.610 1.00 47.02  ?  816  ARG   C CZ    1 
ATOM   4869 N NH1   . ARG   A 1 816  ? 152.737 83.056  129.760 1.00 38.52  1  816  ARG   C NH1   1 
ATOM   4870 N NH2   . ARG   A 1 816  ? 150.584 82.613  130.379 1.00 50.12  ?  816  ARG   C NH2   1 
ATOM   4871 N N     . LEU   A 1 817  ? 155.867 82.658  136.339 1.00 30.97  ?  817  LEU   C N     1 
ATOM   4872 C CA    . LEU   A 1 817  ? 157.295 82.518  136.606 1.00 29.31  ?  817  LEU   C CA    1 
ATOM   4873 C C     . LEU   A 1 817  ? 157.544 81.841  137.942 1.00 32.88  ?  817  LEU   C C     1 
ATOM   4874 O O     . LEU   A 1 817  ? 158.432 80.993  138.070 1.00 34.30  ?  817  LEU   C O     1 
ATOM   4875 C CB    . LEU   A 1 817  ? 157.977 83.886  136.638 1.00 26.04  ?  817  LEU   C CB    1 
ATOM   4876 C CG    . LEU   A 1 817  ? 158.058 84.655  135.328 1.00 25.80  ?  817  LEU   C CG    1 
ATOM   4877 C CD1   . LEU   A 1 817  ? 158.634 86.025  135.624 1.00 36.57  ?  817  LEU   C CD1   1 
ATOM   4878 C CD2   . LEU   A 1 817  ? 158.926 83.905  134.329 1.00 29.69  ?  817  LEU   C CD2   1 
ATOM   4879 N N     . LEU   A 1 818  ? 156.757 82.210  138.942 1.00 32.19  ?  818  LEU   C N     1 
ATOM   4880 C CA    . LEU   A 1 818  ? 156.932 81.639  140.263 1.00 31.34  ?  818  LEU   C CA    1 
ATOM   4881 C C     . LEU   A 1 818  ? 156.692 80.141  140.203 1.00 35.77  ?  818  LEU   C C     1 
ATOM   4882 O O     . LEU   A 1 818  ? 157.429 79.357  140.803 1.00 35.99  ?  818  LEU   C O     1 
ATOM   4883 C CB    . LEU   A 1 818  ? 155.953 82.283  141.251 1.00 27.66  ?  818  LEU   C CB    1 
ATOM   4884 C CG    . LEU   A 1 818  ? 156.070 81.857  142.718 1.00 25.58  ?  818  LEU   C CG    1 
ATOM   4885 C CD1   . LEU   A 1 818  ? 157.430 82.259  143.273 1.00 24.94  ?  818  LEU   C CD1   1 
ATOM   4886 C CD2   . LEU   A 1 818  ? 154.947 82.508  143.505 1.00 26.65  ?  818  LEU   C CD2   1 
ATOM   4887 N N     . CYS   A 1 819  ? 155.671 79.749  139.447 1.00 35.13  ?  819  CYS   C N     1 
ATOM   4888 C CA    . CYS   A 1 819  ? 155.306 78.351  139.297 1.00 37.42  ?  819  CYS   C CA    1 
ATOM   4889 C C     . CYS   A 1 819  ? 156.412 77.551  138.627 1.00 39.92  ?  819  CYS   C C     1 
ATOM   4890 O O     . CYS   A 1 819  ? 156.626 76.387  138.964 1.00 41.41  ?  819  CYS   C O     1 
ATOM   4891 C CB    . CYS   A 1 819  ? 154.005 78.219  138.516 1.00 38.81  ?  819  CYS   C CB    1 
ATOM   4892 S SG    . CYS   A 1 819  ? 152.561 78.818  139.435 1.00 44.75  ?  819  CYS   C SG    1 
ATOM   4893 N N     . VAL   A 1 820  ? 157.145 78.168  137.708 1.00 37.11  ?  820  VAL   C N     1 
ATOM   4894 C CA    . VAL   A 1 820  ? 158.243 77.453  137.074 1.00 38.39  ?  820  VAL   C CA    1 
ATOM   4895 C C     . VAL   A 1 820  ? 159.248 77.030  138.132 1.00 38.26  ?  820  VAL   C C     1 
ATOM   4896 O O     . VAL   A 1 820  ? 159.734 75.899  138.121 1.00 41.03  ?  820  VAL   C O     1 
ATOM   4897 C CB    . VAL   A 1 820  ? 158.939 78.319  136.006 1.00 37.74  ?  820  VAL   C CB    1 
ATOM   4898 C CG1   . VAL   A 1 820  ? 160.222 77.640  135.527 1.00 38.15  ?  820  VAL   C CG1   1 
ATOM   4899 C CG2   . VAL   A 1 820  ? 157.993 78.528  134.835 1.00 47.78  ?  820  VAL   C CG2   1 
ATOM   4900 N N     . GLY   A 1 821  ? 159.549 77.935  139.054 1.00 36.52  ?  821  GLY   C N     1 
ATOM   4901 C CA    . GLY   A 1 821  ? 160.450 77.614  140.153 1.00 40.37  ?  821  GLY   C CA    1 
ATOM   4902 C C     . GLY   A 1 821  ? 159.845 76.552  141.073 1.00 40.25  ?  821  GLY   C C     1 
ATOM   4903 O O     . GLY   A 1 821  ? 160.525 75.613  141.484 1.00 42.41  ?  821  GLY   C O     1 
ATOM   4904 N N     . LEU   A 1 822  ? 158.559 76.695  141.383 1.00 36.21  ?  822  LEU   C N     1 
ATOM   4905 C CA    . LEU   A 1 822  ? 157.885 75.798  142.319 1.00 34.05  ?  822  LEU   C CA    1 
ATOM   4906 C C     . LEU   A 1 822  ? 157.804 74.365  141.801 1.00 39.89  ?  822  LEU   C C     1 
ATOM   4907 O O     . LEU   A 1 822  ? 157.806 73.416  142.585 1.00 42.31  ?  822  LEU   C O     1 
ATOM   4908 C CB    . LEU   A 1 822  ? 156.471 76.309  142.609 1.00 32.92  ?  822  LEU   C CB    1 
ATOM   4909 C CG    . LEU   A 1 822  ? 156.378 77.645  143.363 1.00 29.81  ?  822  LEU   C CG    1 
ATOM   4910 C CD1   . LEU   A 1 822  ? 154.939 78.132  143.352 1.00 33.30  ?  822  LEU   C CD1   1 
ATOM   4911 C CD2   . LEU   A 1 822  ? 156.854 77.470  144.781 1.00 30.09  ?  822  LEU   C CD2   1 
ATOM   4912 N N     . LYS   A 1 823  ? 157.736 74.201  140.485 1.00 39.21  ?  823  LYS   C N     1 
ATOM   4913 C CA    . LYS   A 1 823  ? 157.655 72.873  139.886 1.00 40.39  ?  823  LYS   C CA    1 
ATOM   4914 C C     . LYS   A 1 823  ? 159.031 72.241  139.724 1.00 40.79  ?  823  LYS   C C     1 
ATOM   4915 O O     . LYS   A 1 823  ? 159.146 71.099  139.276 1.00 42.59  ?  823  LYS   C O     1 
ATOM   4916 C CB    . LYS   A 1 823  ? 156.988 72.937  138.512 1.00 40.62  ?  823  LYS   C CB    1 
ATOM   4917 C CG    . LYS   A 1 823  ? 155.529 73.350  138.516 1.00 41.94  ?  823  LYS   C CG    1 
ATOM   4918 C CD    . LYS   A 1 823  ? 154.903 73.200  137.133 1.00 43.16  ?  823  LYS   C CD    1 
ATOM   4919 C CE    . LYS   A 1 823  ? 155.420 74.269  136.165 1.00 45.41  ?  823  LYS   C CE    1 
ATOM   4920 N NZ    . LYS   A 1 823  ? 154.666 74.269  134.877 1.00 49.91  1  823  LYS   C NZ    1 
ATOM   4921 N N     . HIS   A 1 824  ? 160.078 72.993  140.040 1.00 41.31  ?  824  HIS   C N     1 
ATOM   4922 C CA    . HIS   A 1 824  ? 161.434 72.509  139.858 1.00 45.50  ?  824  HIS   C CA    1 
ATOM   4923 C C     . HIS   A 1 824  ? 161.775 71.469  140.911 1.00 45.78  ?  824  HIS   C C     1 
ATOM   4924 O O     . HIS   A 1 824  ? 161.389 71.593  142.076 1.00 46.20  ?  824  HIS   C O     1 
ATOM   4925 C CB    . HIS   A 1 824  ? 162.441 73.660  139.922 1.00 45.72  ?  824  HIS   C CB    1 
ATOM   4926 C CG    . HIS   A 1 824  ? 163.777 73.312  139.342 1.00 50.48  ?  824  HIS   C CG    1 
ATOM   4927 N ND1   . HIS   A 1 824  ? 164.721 72.565  140.019 1.00 50.56  ?  824  HIS   C ND1   1 
ATOM   4928 C CD2   . HIS   A 1 824  ? 164.319 73.603  138.140 1.00 56.87  ?  824  HIS   C CD2   1 
ATOM   4929 C CE1   . HIS   A 1 824  ? 165.786 72.415  139.255 1.00 55.74  ?  824  HIS   C CE1   1 
ATOM   4930 N NE2   . HIS   A 1 824  ? 165.568 73.036  138.110 1.00 59.06  ?  824  HIS   C NE2   1 
ATOM   4931 N N     . LEU   A 1 825  ? 162.521 70.452  140.514 1.00 46.18  ?  825  LEU   C N     1 
ATOM   4932 C CA    . LEU   A 1 825  ? 162.933 69.448  141.472 1.00 46.46  ?  825  LEU   C CA    1 
ATOM   4933 C C     . LEU   A 1 825  ? 163.800 70.070  142.543 1.00 47.90  ?  825  LEU   C C     1 
ATOM   4934 O O     . LEU   A 1 825  ? 164.518 71.041  142.304 1.00 47.55  ?  825  LEU   C O     1 
ATOM   4935 C CB    . LEU   A 1 825  ? 163.696 68.312  140.787 1.00 49.82  ?  825  LEU   C CB    1 
ATOM   4936 C CG    . LEU   A 1 825  ? 162.884 67.436  139.822 1.00 56.27  ?  825  LEU   C CG    1 
ATOM   4937 C CD1   . LEU   A 1 825  ? 163.827 66.487  139.110 1.00 63.11  ?  825  LEU   C CD1   1 
ATOM   4938 C CD2   . LEU   A 1 825  ? 161.820 66.650  140.600 1.00 53.18  ?  825  LEU   C CD2   1 
ATOM   4939 N N     . LEU   A 1 826  ? 163.706 69.508  143.737 1.00 48.07  ?  826  LEU   C N     1 
ATOM   4940 C CA    . LEU   A 1 826  ? 164.448 69.952  144.909 1.00 47.92  ?  826  LEU   C CA    1 
ATOM   4941 C C     . LEU   A 1 826  ? 163.929 71.264  145.497 1.00 45.10  ?  826  LEU   C C     1 
ATOM   4942 O O     . LEU   A 1 826  ? 164.477 71.754  146.482 1.00 45.22  ?  826  LEU   C O     1 
ATOM   4943 C CB    . LEU   A 1 826  ? 165.937 70.119  144.570 1.00 48.82  ?  826  LEU   C CB    1 
ATOM   4944 C CG    . LEU   A 1 826  ? 166.641 68.919  143.907 1.00 53.60  ?  826  LEU   C CG    1 
ATOM   4945 C CD1   . LEU   A 1 826  ? 168.079 69.304  143.593 1.00 54.66  ?  826  LEU   C CD1   1 
ATOM   4946 C CD2   . LEU   A 1 826  ? 166.602 67.723  144.841 1.00 57.00  ?  826  LEU   C CD2   1 
ATOM   4947 N N     . CYS   A 1 827  ? 162.832 71.802  144.966 1.00 43.12  ?  827  CYS   C N     1 
ATOM   4948 C CA    . CYS   A 1 827  ? 162.232 72.950  145.629 1.00 39.59  ?  827  CYS   C CA    1 
ATOM   4949 C C     . CYS   A 1 827  ? 161.468 72.439  146.838 1.00 39.91  ?  827  CYS   C C     1 
ATOM   4950 O O     . CYS   A 1 827  ? 160.541 71.643  146.705 1.00 43.24  ?  827  CYS   C O     1 
ATOM   4951 C CB    . CYS   A 1 827  ? 161.286 73.711  144.702 1.00 42.17  ?  827  CYS   C CB    1 
ATOM   4952 S SG    . CYS   A 1 827  ? 160.521 75.154  145.479 1.00 45.44  ?  827  CYS   C SG    1 
ATOM   4953 N N     . ASN   A 1 828  ? 161.876 72.872  148.023 1.00 34.79  ?  828  ASN   C N     1 
ATOM   4954 C CA    . ASN   A 1 828  ? 161.316 72.333  149.253 1.00 31.70  ?  828  ASN   C CA    1 
ATOM   4955 C C     . ASN   A 1 828  ? 160.306 73.258  149.912 1.00 28.17  ?  828  ASN   C C     1 
ATOM   4956 O O     . ASN   A 1 828  ? 159.967 73.081  151.078 1.00 30.25  ?  828  ASN   C O     1 
ATOM   4957 C CB    . ASN   A 1 828  ? 162.434 71.976  150.217 1.00 34.63  ?  828  ASN   C CB    1 
ATOM   4958 C CG    . ASN   A 1 828  ? 163.215 70.777  149.746 1.00 42.37  ?  828  ASN   C CG    1 
ATOM   4959 O OD1   . ASN   A 1 828  ? 162.621 69.836  149.205 1.00 43.69  ?  828  ASN   C OD1   1 
ATOM   4960 N ND2   . ASN   A 1 828  ? 164.514 70.784  149.939 1.00 44.85  ?  828  ASN   C ND2   1 
ATOM   4961 N N     . LEU   A 1 829  ? 159.821 74.243  149.168 1.00 24.95  ?  829  LEU   C N     1 
ATOM   4962 C CA    . LEU   A 1 829  ? 158.860 75.177  149.735 1.00 22.03  ?  829  LEU   C CA    1 
ATOM   4963 C C     . LEU   A 1 829  ? 157.612 74.435  150.192 1.00 24.66  ?  829  LEU   C C     1 
ATOM   4964 O O     . LEU   A 1 829  ? 157.045 73.646  149.444 1.00 30.42  ?  829  LEU   C O     1 
ATOM   4965 C CB    . LEU   A 1 829  ? 158.461 76.231  148.694 1.00 18.50  ?  829  LEU   C CB    1 
ATOM   4966 C CG    . LEU   A 1 829  ? 157.637 77.415  149.227 1.00 16.98  ?  829  LEU   C CG    1 
ATOM   4967 C CD1   . LEU   A 1 829  ? 158.523 78.299  150.077 1.00 21.11  ?  829  LEU   C CD1   1 
ATOM   4968 C CD2   . LEU   A 1 829  ? 157.050 78.191  148.077 1.00 16.73  ?  829  LEU   C CD2   1 
ATOM   4969 N N     . LYS   A 1 830  ? 157.184 74.700  151.426 1.00 22.99  ?  830  LYS   C N     1 
ATOM   4970 C CA    . LYS   A 1 830  ? 156.007 74.035  151.975 1.00 22.06  ?  830  LYS   C CA    1 
ATOM   4971 C C     . LYS   A 1 830  ? 154.812 74.968  152.096 1.00 22.21  ?  830  LYS   C C     1 
ATOM   4972 O O     . LYS   A 1 830  ? 153.668 74.547  151.881 1.00 28.86  ?  830  LYS   C O     1 
ATOM   4973 C CB    . LYS   A 1 830  ? 156.325 73.435  153.342 1.00 21.08  ?  830  LYS   C CB    1 
ATOM   4974 C CG    . LYS   A 1 830  ? 157.313 72.280  153.302 1.00 26.02  ?  830  LYS   C CG    1 
ATOM   4975 C CD    . LYS   A 1 830  ? 157.506 71.662  154.679 1.00 27.94  ?  830  LYS   C CD    1 
ATOM   4976 C CE    . LYS   A 1 830  ? 158.521 70.531  154.640 1.00 30.61  ?  830  LYS   C CE    1 
ATOM   4977 N NZ    . LYS   A 1 830  ? 158.737 69.938  155.987 1.00 34.65  1  830  LYS   C NZ    1 
ATOM   4978 N N     . LYS   A 1 831  ? 155.058 76.227  152.443 1.00 17.86  ?  831  LYS   C N     1 
ATOM   4979 C CA    . LYS   A 1 831  ? 153.963 77.172  152.632 1.00 11.67  ?  831  LYS   C CA    1 
ATOM   4980 C C     . LYS   A 1 831  ? 154.099 78.368  151.706 1.00 13.67  ?  831  LYS   C C     1 
ATOM   4981 O O     . LYS   A 1 831  ? 155.096 79.091  151.764 1.00 41.23  ?  831  LYS   C O     1 
ATOM   4982 C CB    . LYS   A 1 831  ? 153.925 77.669  154.073 1.00 20.40  ?  831  LYS   C CB    1 
ATOM   4983 C CG    . LYS   A 1 831  ? 153.845 76.579  155.126 1.00 26.82  ?  831  LYS   C CG    1 
ATOM   4984 C CD    . LYS   A 1 831  ? 153.706 77.169  156.516 1.00 30.56  ?  831  LYS   C CD    1 
ATOM   4985 C CE    . LYS   A 1 831  ? 153.744 76.086  157.580 1.00 36.44  ?  831  LYS   C CE    1 
ATOM   4986 N NZ    . LYS   A 1 831  ? 153.745 76.656  158.957 1.00 39.26  1  831  LYS   C NZ    1 
ATOM   4987 N N     . LEU   A 1 832  ? 153.099 78.594  150.866 1.00 16.50  ?  832  LEU   C N     1 
ATOM   4988 C CA    . LEU   A 1 832  ? 153.138 79.721  149.946 1.00 0.00   ?  832  LEU   C CA    1 
ATOM   4989 C C     . LEU   A 1 832  ? 151.945 80.645  150.109 1.00 0.15   ?  832  LEU   C C     1 
ATOM   4990 O O     . LEU   A 1 832  ? 150.797 80.242  149.902 1.00 4.99   ?  832  LEU   C O     1 
ATOM   4991 C CB    . LEU   A 1 832  ? 153.191 79.219  148.504 1.00 0.35   ?  832  LEU   C CB    1 
ATOM   4992 C CG    . LEU   A 1 832  ? 153.100 80.289  147.409 1.00 11.03  ?  832  LEU   C CG    1 
ATOM   4993 C CD1   . LEU   A 1 832  ? 154.297 81.226  147.483 1.00 0.03   ?  832  LEU   C CD1   1 
ATOM   4994 C CD2   . LEU   A 1 832  ? 153.045 79.601  146.067 1.00 16.18  ?  832  LEU   C CD2   1 
ATOM   4995 N N     . TRP   A 1 833  ? 152.221 81.893  150.449 1.00 1.49   ?  833  TRP   C N     1 
ATOM   4996 C CA    . TRP   A 1 833  ? 151.163 82.877  150.617 1.00 10.44  ?  833  TRP   C CA    1 
ATOM   4997 C C     . TRP   A 1 833  ? 151.123 83.833  149.435 1.00 0.42   ?  833  TRP   C C     1 
ATOM   4998 O O     . TRP   A 1 833  ? 152.107 84.516  149.146 1.00 0.03   ?  833  TRP   C O     1 
ATOM   4999 C CB    . TRP   A 1 833  ? 151.380 83.681  151.895 1.00 2.84   ?  833  TRP   C CB    1 
ATOM   5000 C CG    . TRP   A 1 833  ? 151.312 82.893  153.146 1.00 10.93  ?  833  TRP   C CG    1 
ATOM   5001 C CD1   . TRP   A 1 833  ? 152.280 82.080  153.642 1.00 13.35  ?  833  TRP   C CD1   1 
ATOM   5002 C CD2   . TRP   A 1 833  ? 150.228 82.842  154.085 1.00 11.17  ?  833  TRP   C CD2   1 
ATOM   5003 N NE1   . TRP   A 1 833  ? 151.870 81.528  154.822 1.00 11.08  ?  833  TRP   C NE1   1 
ATOM   5004 C CE2   . TRP   A 1 833  ? 150.625 81.994  155.116 1.00 12.62  ?  833  TRP   C CE2   1 
ATOM   5005 C CE3   . TRP   A 1 833  ? 148.983 83.466  154.154 1.00 19.67  ?  833  TRP   C CE3   1 
ATOM   5006 C CZ2   . TRP   A 1 833  ? 149.809 81.719  156.188 1.00 22.49  ?  833  TRP   C CZ2   1 
ATOM   5007 C CZ3   . TRP   A 1 833  ? 148.162 83.192  155.235 1.00 27.59  ?  833  TRP   C CZ3   1 
ATOM   5008 C CH2   . TRP   A 1 833  ? 148.570 82.346  156.230 1.00 30.26  ?  833  TRP   C CH2   1 
ATOM   5009 N N     . LEU   A 1 834  ? 149.981 83.903  148.766 1.00 14.15  ?  834  LEU   C N     1 
ATOM   5010 C CA    . LEU   A 1 834  ? 149.800 84.804  147.637 1.00 15.59  ?  834  LEU   C CA    1 
ATOM   5011 C C     . LEU   A 1 834  ? 148.567 85.663  147.836 1.00 10.74  ?  834  LEU   C C     1 
ATOM   5012 O O     . LEU   A 1 834  ? 147.776 85.856  146.911 1.00 17.52  ?  834  LEU   C O     1 
ATOM   5013 C CB    . LEU   A 1 834  ? 149.661 84.015  146.335 1.00 17.29  ?  834  LEU   C CB    1 
ATOM   5014 C CG    . LEU   A 1 834  ? 150.852 83.164  145.933 1.00 16.04  ?  834  LEU   C CG    1 
ATOM   5015 C CD1   . LEU   A 1 834  ? 150.445 82.263  144.782 1.00 21.14  ?  834  LEU   C CD1   1 
ATOM   5016 C CD2   . LEU   A 1 834  ? 152.006 84.059  145.536 1.00 20.87  ?  834  LEU   C CD2   1 
ATOM   5017 N N     . VAL   A 1 835  ? 148.398 86.161  149.046 1.00 9.06   ?  835  VAL   C N     1 
ATOM   5018 C CA    . VAL   A 1 835  ? 147.226 86.942  149.393 1.00 11.37  ?  835  VAL   C CA    1 
ATOM   5019 C C     . VAL   A 1 835  ? 147.291 88.337  148.801 1.00 13.60  ?  835  VAL   C C     1 
ATOM   5020 O O     . VAL   A 1 835  ? 148.337 88.984  148.840 1.00 17.14  ?  835  VAL   C O     1 
ATOM   5021 C CB    . VAL   A 1 835  ? 147.084 87.022  150.920 1.00 12.48  ?  835  VAL   C CB    1 
ATOM   5022 C CG1   . VAL   A 1 835  ? 145.912 87.917  151.301 1.00 16.73  ?  835  VAL   C CG1   1 
ATOM   5023 C CG2   . VAL   A 1 835  ? 146.887 85.616  151.464 1.00 19.99  ?  835  VAL   C CG2   1 
ATOM   5024 N N     . SER   A 1 836  ? 146.177 88.791  148.242 1.00 16.02  ?  836  SER   C N     1 
ATOM   5025 C CA    . SER   A 1 836  ? 146.098 90.128  147.662 1.00 13.92  ?  836  SER   C CA    1 
ATOM   5026 C C     . SER   A 1 836  ? 147.188 90.367  146.634 1.00 13.75  ?  836  SER   C C     1 
ATOM   5027 O O     . SER   A 1 836  ? 147.927 91.345  146.715 1.00 19.99  ?  836  SER   C O     1 
ATOM   5028 C CB    . SER   A 1 836  ? 146.189 91.181  148.750 1.00 18.86  ?  836  SER   C CB    1 
ATOM   5029 O OG    . SER   A 1 836  ? 145.131 91.076  149.662 1.00 24.71  ?  836  SER   C OG    1 
ATOM   5030 N N     . CYS   A 1 837  ? 147.293 89.467  145.664 1.00 14.28  ?  837  CYS   C N     1 
ATOM   5031 C CA    . CYS   A 1 837  ? 148.313 89.580  144.634 1.00 16.03  ?  837  CYS   C CA    1 
ATOM   5032 C C     . CYS   A 1 837  ? 147.713 89.942  143.290 1.00 19.24  ?  837  CYS   C C     1 
ATOM   5033 O O     . CYS   A 1 837  ? 148.343 89.762  142.253 1.00 22.08  ?  837  CYS   C O     1 
ATOM   5034 C CB    . CYS   A 1 837  ? 149.083 88.275  144.507 1.00 18.65  ?  837  CYS   C CB    1 
ATOM   5035 S SG    . CYS   A 1 837  ? 150.079 87.900  145.922 1.00 25.48  ?  837  CYS   C SG    1 
ATOM   5036 N N     . CYS   A 1 838  ? 146.490 90.453  143.312 1.00 19.12  ?  838  CYS   C N     1 
ATOM   5037 C CA    . CYS   A 1 838  ? 145.799 90.828  142.089 1.00 17.58  ?  838  CYS   C CA    1 
ATOM   5038 C C     . CYS   A 1 838  ? 145.767 89.668  141.113 1.00 17.61  ?  838  CYS   C C     1 
ATOM   5039 O O     . CYS   A 1 838  ? 146.008 89.847  139.919 1.00 22.32  ?  838  CYS   C O     1 
ATOM   5040 C CB    . CYS   A 1 838  ? 146.485 92.018  141.424 1.00 19.17  ?  838  CYS   C CB    1 
ATOM   5041 S SG    . CYS   A 1 838  ? 146.592 93.477  142.474 1.00 60.93  ?  838  CYS   C SG    1 
ATOM   5042 N N     . LEU   A 1 839  ? 145.468 88.477  141.614 1.00 17.57  ?  839  LEU   C N     1 
ATOM   5043 C CA    . LEU   A 1 839  ? 145.425 87.322  140.740 1.00 18.76  ?  839  LEU   C CA    1 
ATOM   5044 C C     . LEU   A 1 839  ? 144.091 87.213  140.054 1.00 24.89  ?  839  LEU   C C     1 
ATOM   5045 O O     . LEU   A 1 839  ? 143.061 87.613  140.598 1.00 27.31  ?  839  LEU   C O     1 
ATOM   5046 C CB    . LEU   A 1 839  ? 145.678 86.029  141.510 1.00 17.33  ?  839  LEU   C CB    1 
ATOM   5047 C CG    . LEU   A 1 839  ? 146.963 85.965  142.283 1.00 16.27  ?  839  LEU   C CG    1 
ATOM   5048 C CD1   . LEU   A 1 839  ? 147.114 84.576  142.883 1.00 18.58  ?  839  LEU   C CD1   1 
ATOM   5049 C CD2   . LEU   A 1 839  ? 148.108 86.312  141.383 1.00 21.60  ?  839  LEU   C CD2   1 
ATOM   5050 N N     . THR   A 1 840  ? 144.112 86.642  138.865 1.00 21.61  ?  840  THR   C N     1 
ATOM   5051 C CA    . THR   A 1 840  ? 142.904 86.378  138.115 1.00 23.44  ?  840  THR   C CA    1 
ATOM   5052 C C     . THR   A 1 840  ? 142.884 84.917  137.716 1.00 27.18  ?  840  THR   C C     1 
ATOM   5053 O O     . THR   A 1 840  ? 143.882 84.210  137.870 1.00 30.79  ?  840  THR   C O     1 
ATOM   5054 C CB    . THR   A 1 840  ? 142.816 87.277  136.875 1.00 27.52  ?  840  THR   C CB    1 
ATOM   5055 O OG1   . THR   A 1 840  ? 143.867 86.934  135.964 1.00 38.93  ?  840  THR   C OG1   1 
ATOM   5056 C CG2   . THR   A 1 840  ? 142.960 88.740  137.284 1.00 24.79  ?  840  THR   C CG2   1 
ATOM   5057 N N     . SER   A 1 841  ? 141.757 84.461  137.190 1.00 26.53  ?  841  SER   C N     1 
ATOM   5058 C CA    . SER   A 1 841  ? 141.602 83.060  136.829 1.00 30.86  ?  841  SER   C CA    1 
ATOM   5059 C C     . SER   A 1 841  ? 142.622 82.630  135.789 1.00 33.90  ?  841  SER   C C     1 
ATOM   5060 O O     . SER   A 1 841  ? 142.953 81.453  135.680 1.00 38.17  ?  841  SER   C O     1 
ATOM   5061 C CB    . SER   A 1 841  ? 140.203 82.821  136.302 1.00 35.91  ?  841  SER   C CB    1 
ATOM   5062 O OG    . SER   A 1 841  ? 140.005 83.496  135.093 1.00 34.89  ?  841  SER   C OG    1 
ATOM   5063 N N     . ALA   A 1 842  ? 143.154 83.589  135.053 1.00 33.18  ?  842  ALA   C N     1 
ATOM   5064 C CA    . ALA   A 1 842  ? 144.114 83.314  133.993 1.00 39.51  ?  842  ALA   C CA    1 
ATOM   5065 C C     . ALA   A 1 842  ? 145.359 82.599  134.509 1.00 40.12  ?  842  ALA   C C     1 
ATOM   5066 O O     . ALA   A 1 842  ? 146.050 81.927  133.745 1.00 40.44  ?  842  ALA   C O     1 
ATOM   5067 C CB    . ALA   A 1 842  ? 144.522 84.611  133.318 1.00 37.43  ?  842  ALA   C CB    1 
ATOM   5068 N N     . CYS   A 1 843  ? 145.673 82.774  135.786 1.00 36.87  ?  843  CYS   C N     1 
ATOM   5069 C CA    . CYS   A 1 843  ? 146.894 82.205  136.342 1.00 37.09  ?  843  CYS   C CA    1 
ATOM   5070 C C     . CYS   A 1 843  ? 146.648 80.963  137.185 1.00 36.75  ?  843  CYS   C C     1 
ATOM   5071 O O     . CYS   A 1 843  ? 147.595 80.332  137.666 1.00 38.88  ?  843  CYS   C O     1 
ATOM   5072 C CB    . CYS   A 1 843  ? 147.592 83.236  137.206 1.00 39.35  ?  843  CYS   C CB    1 
ATOM   5073 S SG    . CYS   A 1 843  ? 146.764 83.553  138.779 1.00 47.59  ?  843  CYS   C SG    1 
ATOM   5074 N N     . CYS   A 1 844  ? 145.387 80.608  137.378 1.00 34.82  ?  844  CYS   C N     1 
ATOM   5075 C CA    . CYS   A 1 844  ? 145.072 79.495  138.262 1.00 38.79  ?  844  CYS   C CA    1 
ATOM   5076 C C     . CYS   A 1 844  ? 145.549 78.191  137.661 1.00 39.37  ?  844  CYS   C C     1 
ATOM   5077 O O     . CYS   A 1 844  ? 145.751 77.205  138.369 1.00 40.95  ?  844  CYS   C O     1 
ATOM   5078 C CB    . CYS   A 1 844  ? 143.578 79.383  138.487 1.00 43.43  ?  844  CYS   C CB    1 
ATOM   5079 S SG    . CYS   A 1 844  ? 142.717 78.805  137.044 1.00 58.60  ?  844  CYS   C SG    1 
ATOM   5080 N N     . GLN   A 1 845  ? 145.714 78.184  136.345 1.00 39.38  ?  845  GLN   C N     1 
ATOM   5081 C CA    . GLN   A 1 845  ? 146.124 76.988  135.641 1.00 42.09  ?  845  GLN   C CA    1 
ATOM   5082 C C     . GLN   A 1 845  ? 147.529 76.586  136.051 1.00 44.51  ?  845  GLN   C C     1 
ATOM   5083 O O     . GLN   A 1 845  ? 147.847 75.397  136.110 1.00 44.65  ?  845  GLN   C O     1 
ATOM   5084 C CB    . GLN   A 1 845  ? 146.056 77.211  134.130 1.00 42.05  ?  845  GLN   C CB    1 
ATOM   5085 C CG    . GLN   A 1 845  ? 146.273 75.957  133.305 1.00 43.50  ?  845  GLN   C CG    1 
ATOM   5086 C CD    . GLN   A 1 845  ? 145.164 74.936  133.493 1.00 49.58  ?  845  GLN   C CD    1 
ATOM   5087 O OE1   . GLN   A 1 845  ? 143.994 75.214  133.215 1.00 45.38  ?  845  GLN   C OE1   1 
ATOM   5088 N NE2   . GLN   A 1 845  ? 145.524 73.751  133.969 1.00 52.34  ?  845  GLN   C NE2   1 
ATOM   5089 N N     . ASP   A 1 846  ? 148.378 77.570  136.332 1.00 39.07  ?  846  ASP   C N     1 
ATOM   5090 C CA    . ASP   A 1 846  ? 149.753 77.265  136.674 1.00 38.70  ?  846  ASP   C CA    1 
ATOM   5091 C C     . ASP   A 1 846  ? 149.852 76.862  138.130 1.00 42.47  ?  846  ASP   C C     1 
ATOM   5092 O O     . ASP   A 1 846  ? 150.624 75.972  138.482 1.00 43.92  ?  846  ASP   C O     1 
ATOM   5093 C CB    . ASP   A 1 846  ? 150.655 78.462  136.400 1.00 37.01  ?  846  ASP   C CB    1 
ATOM   5094 C CG    . ASP   A 1 846  ? 150.768 78.789  134.931 1.00 41.82  ?  846  ASP   C CG    1 
ATOM   5095 O OD1   . ASP   A 1 846  ? 151.102 77.914  134.169 1.00 42.45  ?  846  ASP   C OD1   1 
ATOM   5096 O OD2   . ASP   A 1 846  ? 150.520 79.915  134.577 1.00 42.85  -1 846  ASP   C OD2   1 
ATOM   5097 N N     . LEU   A 1 847  ? 149.041 77.492  138.975 1.00 41.00  ?  847  LEU   C N     1 
ATOM   5098 C CA    . LEU   A 1 847  ? 149.035 77.125  140.385 1.00 38.56  ?  847  LEU   C CA    1 
ATOM   5099 C C     . LEU   A 1 847  ? 148.496 75.717  140.534 1.00 41.66  ?  847  LEU   C C     1 
ATOM   5100 O O     . LEU   A 1 847  ? 148.969 74.943  141.375 1.00 40.76  ?  847  LEU   C O     1 
ATOM   5101 C CB    . LEU   A 1 847  ? 148.186 78.116  141.190 1.00 33.72  ?  847  LEU   C CB    1 
ATOM   5102 C CG    . LEU   A 1 847  ? 148.777 79.520  141.356 1.00 32.87  ?  847  LEU   C CG    1 
ATOM   5103 C CD1   . LEU   A 1 847  ? 147.716 80.454  141.915 1.00 28.24  ?  847  LEU   C CD1   1 
ATOM   5104 C CD2   . LEU   A 1 847  ? 149.977 79.461  142.301 1.00 31.00  ?  847  LEU   C CD2   1 
ATOM   5105 N N     . ALA   A 1 848  ? 147.512 75.372  139.714 1.00 40.39  ?  848  ALA   C N     1 
ATOM   5106 C CA    . ALA   A 1 848  ? 146.924 74.049  139.732 1.00 43.39  ?  848  ALA   C CA    1 
ATOM   5107 C C     . ALA   A 1 848  ? 147.964 72.996  139.375 1.00 41.07  ?  848  ALA   C C     1 
ATOM   5108 O O     . ALA   A 1 848  ? 148.047 71.945  140.004 1.00 42.47  ?  848  ALA   C O     1 
ATOM   5109 C CB    . ALA   A 1 848  ? 145.750 73.985  138.777 1.00 47.57  ?  848  ALA   C CB    1 
ATOM   5110 N N     . SER   A 1 849  ? 148.793 73.319  138.377 1.00 38.55  ?  849  SER   C N     1 
ATOM   5111 C CA    . SER   A 1 849  ? 149.847 72.407  137.959 1.00 41.39  ?  849  SER   C CA    1 
ATOM   5112 C C     . SER   A 1 849  ? 150.847 72.188  139.079 1.00 42.40  ?  849  SER   C C     1 
ATOM   5113 O O     . SER   A 1 849  ? 151.334 71.070  139.269 1.00 43.19  ?  849  SER   C O     1 
ATOM   5114 C CB    . SER   A 1 849  ? 150.552 72.954  136.734 1.00 43.08  ?  849  SER   C CB    1 
ATOM   5115 O OG    . SER   A 1 849  ? 149.689 72.980  135.629 1.00 47.44  ?  849  SER   C OG    1 
ATOM   5116 N N     . VAL   A 1 850  ? 151.133 73.239  139.844 1.00 42.30  ?  850  VAL   C N     1 
ATOM   5117 C CA    . VAL   A 1 850  ? 152.055 73.116  140.965 1.00 41.25  ?  850  VAL   C CA    1 
ATOM   5118 C C     . VAL   A 1 850  ? 151.498 72.164  142.011 1.00 40.13  ?  850  VAL   C C     1 
ATOM   5119 O O     . VAL   A 1 850  ? 152.205 71.286  142.495 1.00 40.86  ?  850  VAL   C O     1 
ATOM   5120 C CB    . VAL   A 1 850  ? 152.336 74.481  141.622 1.00 38.51  ?  850  VAL   C CB    1 
ATOM   5121 C CG1   . VAL   A 1 850  ? 153.141 74.287  142.902 1.00 36.77  ?  850  VAL   C CG1   1 
ATOM   5122 C CG2   . VAL   A 1 850  ? 153.105 75.365  140.664 1.00 43.14  ?  850  VAL   C CG2   1 
ATOM   5123 N N     . LEU   A 1 851  ? 150.218 72.311  142.340 1.00 38.33  ?  851  LEU   C N     1 
ATOM   5124 C CA    . LEU   A 1 851  ? 149.616 71.429  143.334 1.00 37.32  ?  851  LEU   C CA    1 
ATOM   5125 C C     . LEU   A 1 851  ? 149.681 69.975  142.894 1.00 41.60  ?  851  LEU   C C     1 
ATOM   5126 O O     . LEU   A 1 851  ? 149.914 69.081  143.710 1.00 42.46  ?  851  LEU   C O     1 
ATOM   5127 C CB    . LEU   A 1 851  ? 148.149 71.811  143.570 1.00 33.94  ?  851  LEU   C CB    1 
ATOM   5128 C CG    . LEU   A 1 851  ? 147.889 73.134  144.300 1.00 33.73  ?  851  LEU   C CG    1 
ATOM   5129 C CD1   . LEU   A 1 851  ? 146.397 73.449  144.239 1.00 42.51  ?  851  LEU   C CD1   1 
ATOM   5130 C CD2   . LEU   A 1 851  ? 148.345 73.016  145.746 1.00 31.02  ?  851  LEU   C CD2   1 
ATOM   5131 N N     . SER   A 1 852  ? 149.486 69.737  141.604 1.00 40.70  ?  852  SER   C N     1 
ATOM   5132 C CA    . SER   A 1 852  ? 149.523 68.385  141.066 1.00 40.79  ?  852  SER   C CA    1 
ATOM   5133 C C     . SER   A 1 852  ? 150.914 67.760  141.118 1.00 42.25  ?  852  SER   C C     1 
ATOM   5134 O O     . SER   A 1 852  ? 151.070 66.608  141.529 1.00 41.93  ?  852  SER   C O     1 
ATOM   5135 C CB    . SER   A 1 852  ? 149.049 68.388  139.630 1.00 45.27  ?  852  SER   C CB    1 
ATOM   5136 O OG    . SER   A 1 852  ? 149.085 67.099  139.087 1.00 50.50  ?  852  SER   C OG    1 
ATOM   5137 N N     . THR   A 1 853  ? 151.921 68.506  140.664 1.00 43.26  ?  853  THR   C N     1 
ATOM   5138 C CA    . THR   A 1 853  ? 153.268 67.956  140.528 1.00 45.93  ?  853  THR   C CA    1 
ATOM   5139 C C     . THR   A 1 853  ? 154.152 68.098  141.770 1.00 45.54  ?  853  THR   C C     1 
ATOM   5140 O O     . THR   A 1 853  ? 155.033 67.267  141.993 1.00 44.67  ?  853  THR   C O     1 
ATOM   5141 C CB    . THR   A 1 853  ? 153.983 68.580  139.311 1.00 46.79  ?  853  THR   C CB    1 
ATOM   5142 O OG1   . THR   A 1 853  ? 155.087 67.752  138.932 1.00 44.54  ?  853  THR   C OG1   1 
ATOM   5143 C CG2   . THR   A 1 853  ? 154.499 69.979  139.625 1.00 47.73  ?  853  THR   C CG2   1 
ATOM   5144 N N     . SER   A 1 854  ? 153.962 69.157  142.553 1.00 43.00  ?  854  SER   C N     1 
ATOM   5145 C CA    . SER   A 1 854  ? 154.834 69.412  143.694 1.00 43.68  ?  854  SER   C CA    1 
ATOM   5146 C C     . SER   A 1 854  ? 154.468 68.541  144.884 1.00 44.18  ?  854  SER   C C     1 
ATOM   5147 O O     . SER   A 1 854  ? 153.317 68.510  145.316 1.00 43.18  ?  854  SER   C O     1 
ATOM   5148 C CB    . SER   A 1 854  ? 154.771 70.873  144.094 1.00 42.56  ?  854  SER   C CB    1 
ATOM   5149 O OG    . SER   A 1 854  ? 155.554 71.116  145.233 1.00 41.54  ?  854  SER   C OG    1 
ATOM   5150 N N     . HIS   A 1 855  ? 155.457 67.834  145.419 1.00 44.03  ?  855  HIS   C N     1 
ATOM   5151 C CA    . HIS   A 1 855  ? 155.240 66.953  146.556 1.00 45.68  ?  855  HIS   C CA    1 
ATOM   5152 C C     . HIS   A 1 855  ? 155.406 67.665  147.892 1.00 45.13  ?  855  HIS   C C     1 
ATOM   5153 O O     . HIS   A 1 855  ? 154.985 67.151  148.929 1.00 45.56  ?  855  HIS   C O     1 
ATOM   5154 C CB    . HIS   A 1 855  ? 156.234 65.796  146.496 1.00 45.98  ?  855  HIS   C CB    1 
ATOM   5155 C CG    . HIS   A 1 855  ? 157.645 66.272  146.553 1.00 47.73  ?  855  HIS   C CG    1 
ATOM   5156 N ND1   . HIS   A 1 855  ? 158.222 66.995  145.530 1.00 45.74  ?  855  HIS   C ND1   1 
ATOM   5157 C CD2   . HIS   A 1 855  ? 158.597 66.143  147.506 1.00 47.30  ?  855  HIS   C CD2   1 
ATOM   5158 C CE1   . HIS   A 1 855  ? 159.468 67.290  145.853 1.00 45.91  ?  855  HIS   C CE1   1 
ATOM   5159 N NE2   . HIS   A 1 855  ? 159.721 66.785  147.044 1.00 46.51  ?  855  HIS   C NE2   1 
ATOM   5160 N N     . SER   A 1 856  ? 156.036 68.837  147.873 1.00 39.94  ?  856  SER   C N     1 
ATOM   5161 C CA    . SER   A 1 856  ? 156.350 69.530  149.117 1.00 37.52  ?  856  SER   C CA    1 
ATOM   5162 C C     . SER   A 1 856  ? 155.363 70.631  149.486 1.00 31.68  ?  856  SER   C C     1 
ATOM   5163 O O     . SER   A 1 856  ? 155.253 70.990  150.655 1.00 32.82  ?  856  SER   C O     1 
ATOM   5164 C CB    . SER   A 1 856  ? 157.748 70.111  149.047 1.00 41.68  ?  856  SER   C CB    1 
ATOM   5165 O OG    . SER   A 1 856  ? 158.711 69.093  148.966 1.00 43.62  ?  856  SER   C OG    1 
ATOM   5166 N N     . LEU   A 1 857  ? 154.639 71.169  148.513 1.00 28.63  ?  857  LEU   C N     1 
ATOM   5167 C CA    . LEU   A 1 857  ? 153.733 72.269  148.821 1.00 24.00  ?  857  LEU   C CA    1 
ATOM   5168 C C     . LEU   A 1 857  ? 152.485 71.741  149.508 1.00 26.77  ?  857  LEU   C C     1 
ATOM   5169 O O     . LEU   A 1 857  ? 151.748 70.939  148.938 1.00 33.94  ?  857  LEU   C O     1 
ATOM   5170 C CB    . LEU   A 1 857  ? 153.346 73.028  147.540 1.00 22.07  ?  857  LEU   C CB    1 
ATOM   5171 C CG    . LEU   A 1 857  ? 152.371 74.231  147.713 1.00 20.08  ?  857  LEU   C CG    1 
ATOM   5172 C CD1   . LEU   A 1 857  ? 153.032 75.320  148.544 1.00 25.32  ?  857  LEU   C CD1   1 
ATOM   5173 C CD2   . LEU   A 1 857  ? 151.989 74.777  146.340 1.00 22.31  ?  857  LEU   C CD2   1 
ATOM   5174 N N     . THR   A 1 858  ? 152.256 72.182  150.743 1.00 25.65  ?  858  THR   C N     1 
ATOM   5175 C CA    . THR   A 1 858  ? 151.123 71.688  151.517 1.00 27.07  ?  858  THR   C CA    1 
ATOM   5176 C C     . THR   A 1 858  ? 150.160 72.792  151.929 1.00 25.49  ?  858  THR   C C     1 
ATOM   5177 O O     . THR   A 1 858  ? 149.002 72.527  152.254 1.00 30.67  ?  858  THR   C O     1 
ATOM   5178 C CB    . THR   A 1 858  ? 151.601 70.940  152.772 1.00 29.51  ?  858  THR   C CB    1 
ATOM   5179 O OG1   . THR   A 1 858  ? 152.352 71.829  153.607 1.00 30.53  ?  858  THR   C OG1   1 
ATOM   5180 C CG2   . THR   A 1 858  ? 152.459 69.754  152.396 1.00 31.84  ?  858  THR   C CG2   1 
ATOM   5181 N N     . ARG   A 1 859  ? 150.630 74.028  151.930 1.00 20.11  ?  859  ARG   C N     1 
ATOM   5182 C CA    . ARG   A 1 859  ? 149.795 75.141  152.356 1.00 18.41  ?  859  ARG   C CA    1 
ATOM   5183 C C     . ARG   A 1 859  ? 149.749 76.211  151.283 1.00 17.98  ?  859  ARG   C C     1 
ATOM   5184 O O     . ARG   A 1 859  ? 150.784 76.770  150.919 1.00 21.97  ?  859  ARG   C O     1 
ATOM   5185 C CB    . ARG   A 1 859  ? 150.339 75.756  153.631 1.00 24.48  ?  859  ARG   C CB    1 
ATOM   5186 C CG    . ARG   A 1 859  ? 149.916 75.105  154.938 1.00 29.06  ?  859  ARG   C CG    1 
ATOM   5187 C CD    . ARG   A 1 859  ? 150.689 73.886  155.241 1.00 32.55  ?  859  ARG   C CD    1 
ATOM   5188 N NE    . ARG   A 1 859  ? 150.499 73.457  156.613 1.00 32.68  ?  859  ARG   C NE    1 
ATOM   5189 C CZ    . ARG   A 1 859  ? 151.057 72.358  157.154 1.00 37.15  ?  859  ARG   C CZ    1 
ATOM   5190 N NH1   . ARG   A 1 859  ? 151.839 71.593  156.425 1.00 36.57  1  859  ARG   C NH1   1 
ATOM   5191 N NH2   . ARG   A 1 859  ? 150.820 72.048  158.418 1.00 36.98  ?  859  ARG   C NH2   1 
ATOM   5192 N N     . LEU   A 1 860  ? 148.557 76.506  150.786 1.00 14.84  ?  860  LEU   C N     1 
ATOM   5193 C CA    . LEU   A 1 860  ? 148.417 77.505  149.738 1.00 0.83   ?  860  LEU   C CA    1 
ATOM   5194 C C     . LEU   A 1 860  ? 147.334 78.514  150.074 1.00 12.99  ?  860  LEU   C C     1 
ATOM   5195 O O     . LEU   A 1 860  ? 146.183 78.142  150.304 1.00 23.27  ?  860  LEU   C O     1 
ATOM   5196 C CB    . LEU   A 1 860  ? 148.085 76.821  148.406 1.00 17.43  ?  860  LEU   C CB    1 
ATOM   5197 C CG    . LEU   A 1 860  ? 147.816 77.753  147.219 1.00 21.65  ?  860  LEU   C CG    1 
ATOM   5198 C CD1   . LEU   A 1 860  ? 149.089 78.524  146.872 1.00 0.25   ?  860  LEU   C CD1   1 
ATOM   5199 C CD2   . LEU   A 1 860  ? 147.345 76.934  146.028 1.00 23.90  ?  860  LEU   C CD2   1 
ATOM   5200 N N     . TYR   A 1 861  ? 147.699 79.787  150.095 1.00 25.48  ?  861  TYR   C N     1 
ATOM   5201 C CA    . TYR   A 1 861  ? 146.738 80.844  150.384 1.00 13.65  ?  861  TYR   C CA    1 
ATOM   5202 C C     . TYR   A 1 861  ? 146.616 81.789  149.201 1.00 17.21  ?  861  TYR   C C     1 
ATOM   5203 O O     . TYR   A 1 861  ? 147.548 82.530  148.892 1.00 32.73  ?  861  TYR   C O     1 
ATOM   5204 C CB    . TYR   A 1 861  ? 147.164 81.612  151.629 1.00 15.77  ?  861  TYR   C CB    1 
ATOM   5205 C CG    . TYR   A 1 861  ? 147.240 80.770  152.866 1.00 15.62  ?  861  TYR   C CG    1 
ATOM   5206 C CD1   . TYR   A 1 861  ? 148.356 79.993  153.098 1.00 16.93  ?  861  TYR   C CD1   1 
ATOM   5207 C CD2   . TYR   A 1 861  ? 146.206 80.784  153.779 1.00 19.86  ?  861  TYR   C CD2   1 
ATOM   5208 C CE1   . TYR   A 1 861  ? 148.438 79.234  154.234 1.00 17.34  ?  861  TYR   C CE1   1 
ATOM   5209 C CE2   . TYR   A 1 861  ? 146.287 80.021  154.918 1.00 21.08  ?  861  TYR   C CE2   1 
ATOM   5210 C CZ    . TYR   A 1 861  ? 147.400 79.247  155.144 1.00 18.84  ?  861  TYR   C CZ    1 
ATOM   5211 O OH    . TYR   A 1 861  ? 147.490 78.487  156.283 1.00 25.20  ?  861  TYR   C OH    1 
ATOM   5212 N N     . VAL   A 1 862  ? 145.476 81.763  148.527 1.00 0.29   ?  862  VAL   C N     1 
ATOM   5213 C CA    . VAL   A 1 862  ? 145.293 82.585  147.337 1.00 0.00   ?  862  VAL   C CA    1 
ATOM   5214 C C     . VAL   A 1 862  ? 144.065 83.466  147.433 1.00 10.21  ?  862  VAL   C C     1 
ATOM   5215 O O     . VAL   A 1 862  ? 143.461 83.817  146.420 1.00 16.15  ?  862  VAL   C O     1 
ATOM   5216 C CB    . VAL   A 1 862  ? 145.210 81.705  146.083 1.00 0.00   ?  862  VAL   C CB    1 
ATOM   5217 C CG1   . VAL   A 1 862  ? 146.527 81.027  145.863 1.00 0.91   ?  862  VAL   C CG1   1 
ATOM   5218 C CG2   . VAL   A 1 862  ? 144.110 80.691  146.250 1.00 14.44  ?  862  VAL   C CG2   1 
ATOM   5219 N N     . GLY   A 1 863  ? 143.687 83.818  148.648 1.00 14.86  ?  863  GLY   C N     1 
ATOM   5220 C CA    . GLY   A 1 863  ? 142.503 84.641  148.850 1.00 21.86  ?  863  GLY   C CA    1 
ATOM   5221 C C     . GLY   A 1 863  ? 142.787 86.116  148.591 1.00 17.71  ?  863  GLY   C C     1 
ATOM   5222 O O     . GLY   A 1 863  ? 143.933 86.508  148.370 1.00 18.80  ?  863  GLY   C O     1 
ATOM   5223 N N     . GLU   A 1 864  ? 141.732 86.923  148.659 1.00 20.75  ?  864  GLU   C N     1 
ATOM   5224 C CA    . GLU   A 1 864  ? 141.780 88.353  148.408 1.00 19.66  ?  864  GLU   C CA    1 
ATOM   5225 C C     . GLU   A 1 864  ? 142.268 88.611  147.000 1.00 18.90  ?  864  GLU   C C     1 
ATOM   5226 O O     . GLU   A 1 864  ? 143.058 89.519  146.760 1.00 24.18  ?  864  GLU   C O     1 
ATOM   5227 C CB    . GLU   A 1 864  ? 142.668 89.069  149.425 1.00 22.50  ?  864  GLU   C CB    1 
ATOM   5228 C CG    . GLU   A 1 864  ? 142.296 88.823  150.880 1.00 28.28  ?  864  GLU   C CG    1 
ATOM   5229 C CD    . GLU   A 1 864  ? 140.945 89.378  151.255 1.00 34.08  ?  864  GLU   C CD    1 
ATOM   5230 O OE1   . GLU   A 1 864  ? 140.406 90.155  150.505 1.00 30.16  ?  864  GLU   C OE1   1 
ATOM   5231 O OE2   . GLU   A 1 864  ? 140.451 89.021  152.297 1.00 35.62  -1 864  GLU   C OE2   1 
ATOM   5232 N N     . ASN   A 1 865  ? 141.784 87.809  146.065 1.00 17.19  ?  865  ASN   C N     1 
ATOM   5233 C CA    . ASN   A 1 865  ? 142.154 87.958  144.670 1.00 17.31  ?  865  ASN   C CA    1 
ATOM   5234 C C     . ASN   A 1 865  ? 140.915 88.020  143.794 1.00 23.27  ?  865  ASN   C C     1 
ATOM   5235 O O     . ASN   A 1 865  ? 139.795 87.924  144.290 1.00 28.76  ?  865  ASN   C O     1 
ATOM   5236 C CB    . ASN   A 1 865  ? 143.073 86.834  144.251 1.00 18.99  ?  865  ASN   C CB    1 
ATOM   5237 C CG    . ASN   A 1 865  ? 144.443 86.982  144.838 1.00 22.78  ?  865  ASN   C CG    1 
ATOM   5238 O OD1   . ASN   A 1 865  ? 145.172 87.938  144.524 1.00 25.53  ?  865  ASN   C OD1   1 
ATOM   5239 N ND2   . ASN   A 1 865  ? 144.818 86.058  145.665 1.00 21.17  ?  865  ASN   C ND2   1 
ATOM   5240 N N     . ALA   A 1 866  ? 141.107 88.185  142.492 1.00 24.06  ?  866  ALA   C N     1 
ATOM   5241 C CA    . ALA   A 1 866  ? 139.989 88.253  141.561 1.00 24.71  ?  866  ALA   C CA    1 
ATOM   5242 C C     . ALA   A 1 866  ? 139.771 86.907  140.896 1.00 25.01  ?  866  ALA   C C     1 
ATOM   5243 O O     . ALA   A 1 866  ? 139.696 86.810  139.671 1.00 30.65  ?  866  ALA   C O     1 
ATOM   5244 C CB    . ALA   A 1 866  ? 140.228 89.328  140.511 1.00 28.71  ?  866  ALA   C CB    1 
ATOM   5245 N N     . LEU   A 1 867  ? 139.652 85.873  141.709 1.00 22.12  ?  867  LEU   C N     1 
ATOM   5246 C CA    . LEU   A 1 867  ? 139.402 84.543  141.195 1.00 21.97  ?  867  LEU   C CA    1 
ATOM   5247 C C     . LEU   A 1 867  ? 137.919 84.371  140.946 1.00 29.27  ?  867  LEU   C C     1 
ATOM   5248 O O     . LEU   A 1 867  ? 137.096 85.084  141.518 1.00 34.45  ?  867  LEU   C O     1 
ATOM   5249 C CB    . LEU   A 1 867  ? 139.906 83.481  142.174 1.00 20.83  ?  867  LEU   C CB    1 
ATOM   5250 C CG    . LEU   A 1 867  ? 141.412 83.504  142.480 1.00 20.17  ?  867  LEU   C CG    1 
ATOM   5251 C CD1   . LEU   A 1 867  ? 141.726 82.439  143.523 1.00 18.79  ?  867  LEU   C CD1   1 
ATOM   5252 C CD2   . LEU   A 1 867  ? 142.206 83.259  141.196 1.00 27.18  ?  867  LEU   C CD2   1 
ATOM   5253 N N     . GLY   A 1 868  ? 137.580 83.446  140.064 1.00 33.52  ?  868  GLY   C N     1 
ATOM   5254 C CA    . GLY   A 1 868  ? 136.185 83.146  139.784 1.00 36.99  ?  868  GLY   C CA    1 
ATOM   5255 C C     . GLY   A 1 868  ? 135.864 81.688  140.069 1.00 38.86  ?  868  GLY   C C     1 
ATOM   5256 O O     . GLY   A 1 868  ? 136.585 81.009  140.805 1.00 38.90  ?  868  GLY   C O     1 
ATOM   5257 N N     . ASP   A 1 869  ? 134.777 81.216  139.473 1.00 41.51  ?  869  ASP   C N     1 
ATOM   5258 C CA    . ASP   A 1 869  ? 134.315 79.854  139.655 1.00 46.81  ?  869  ASP   C CA    1 
ATOM   5259 C C     . ASP   A 1 869  ? 135.218 78.900  138.906 1.00 45.32  ?  869  ASP   C C     1 
ATOM   5260 O O     . ASP   A 1 869  ? 135.598 77.845  139.417 1.00 48.27  ?  869  ASP   C O     1 
ATOM   5261 C CB    . ASP   A 1 869  ? 132.885 79.733  139.141 1.00 53.46  ?  869  ASP   C CB    1 
ATOM   5262 C CG    . ASP   A 1 869  ? 132.768 80.259  137.726 1.00 59.19  ?  869  ASP   C CG    1 
ATOM   5263 O OD1   . ASP   A 1 869  ? 133.615 81.050  137.340 1.00 50.24  ?  869  ASP   C OD1   1 
ATOM   5264 O OD2   . ASP   A 1 869  ? 131.853 79.883  137.039 1.00 63.33  -1 869  ASP   C OD2   1 
ATOM   5265 N N     . SER   A 1 870  ? 135.590 79.294  137.698 1.00 43.45  ?  870  SER   C N     1 
ATOM   5266 C CA    . SER   A 1 870  ? 136.479 78.484  136.889 1.00 46.67  ?  870  SER   C CA    1 
ATOM   5267 C C     . SER   A 1 870  ? 137.854 78.435  137.530 1.00 46.43  ?  870  SER   C C     1 
ATOM   5268 O O     . SER   A 1 870  ? 138.568 77.440  137.423 1.00 45.69  ?  870  SER   C O     1 
ATOM   5269 C CB    . SER   A 1 870  ? 136.579 79.053  135.492 1.00 53.26  ?  870  SER   C CB    1 
ATOM   5270 O OG    . SER   A 1 870  ? 137.218 80.302  135.505 1.00 47.27  ?  870  SER   C OG    1 
ATOM   5271 N N     . GLY   A 1 871  ? 138.205 79.508  138.229 1.00 45.73  ?  871  GLY   C N     1 
ATOM   5272 C CA    . GLY   A 1 871  ? 139.495 79.606  138.889 1.00 50.23  ?  871  GLY   C CA    1 
ATOM   5273 C C     . GLY   A 1 871  ? 139.671 78.506  139.920 1.00 46.81  ?  871  GLY   C C     1 
ATOM   5274 O O     . GLY   A 1 871  ? 140.619 77.716  139.850 1.00 46.60  ?  871  GLY   C O     1 
ATOM   5275 N N     . VAL   A 1 872  ? 138.755 78.440  140.875 1.00 41.06  ?  872  VAL   C N     1 
ATOM   5276 C CA    . VAL   A 1 872  ? 138.858 77.441  141.916 1.00 39.98  ?  872  VAL   C CA    1 
ATOM   5277 C C     . VAL   A 1 872  ? 138.623 76.046  141.358 1.00 45.37  ?  872  VAL   C C     1 
ATOM   5278 O O     . VAL   A 1 872  ? 139.201 75.085  141.832 1.00 45.70  ?  872  VAL   C O     1 
ATOM   5279 C CB    . VAL   A 1 872  ? 137.882 77.718  143.071 1.00 38.34  ?  872  VAL   C CB    1 
ATOM   5280 C CG1   . VAL   A 1 872  ? 136.462 77.376  142.673 1.00 50.49  ?  872  VAL   C CG1   1 
ATOM   5281 C CG2   . VAL   A 1 872  ? 138.291 76.914  144.280 1.00 43.32  ?  872  VAL   C CG2   1 
ATOM   5282 N N     . ALA   A 1 873  ? 137.741 75.962  140.353 1.00 47.91  ?  873  ALA   C N     1 
ATOM   5283 C CA    . ALA   A 1 873  ? 137.426 74.644  139.790 1.00 51.66  ?  873  ALA   C CA    1 
ATOM   5284 C C     . ALA   A 1 873  ? 138.659 74.046  139.157 1.00 50.73  ?  873  ALA   C C     1 
ATOM   5285 O O     . ALA   A 1 873  ? 138.890 72.820  139.311 1.00 50.56  ?  873  ALA   C O     1 
ATOM   5286 C CB    . ALA   A 1 873  ? 136.323 74.807  138.747 1.00 53.48  ?  873  ALA   C CB    1 
ATOM   5287 N N     . ILE   A 1 874  ? 139.486 74.819  138.498 1.00 46.53  ?  874  ILE   C N     1 
ATOM   5288 C CA    . ILE   A 1 874  ? 140.719 74.346  137.920 1.00 42.71  ?  874  ILE   C CA    1 
ATOM   5289 C C     . ILE   A 1 874  ? 141.678 73.856  139.000 1.00 47.42  ?  874  ILE   C C     1 
ATOM   5290 O O     . ILE   A 1 874  ? 142.279 72.800  138.880 1.00 47.85  ?  874  ILE   C O     1 
ATOM   5291 C CB    . ILE   A 1 874  ? 141.362 75.391  137.014 1.00 43.18  ?  874  ILE   C CB    1 
ATOM   5292 C CG1   . ILE   A 1 874  ? 140.490 75.561  135.759 1.00 48.00  ?  874  ILE   C CG1   1 
ATOM   5293 C CG2   . ILE   A 1 874  ? 142.802 75.005  136.653 1.00 46.59  ?  874  ILE   C CG2   1 
ATOM   5294 C CD1   . ILE   A 1 874  ? 140.792 76.792  134.935 1.00 58.00  ?  874  ILE   C CD1   1 
ATOM   5295 N N     . LEU   A 1 875  ? 141.792 74.645  140.077 1.00 47.35  ?  875  LEU   C N     1 
ATOM   5296 C CA    . LEU   A 1 875  ? 142.650 74.217  141.178 1.00 46.98  ?  875  LEU   C CA    1 
ATOM   5297 C C     . LEU   A 1 875  ? 142.129 72.911  141.745 1.00 48.43  ?  875  LEU   C C     1 
ATOM   5298 O O     . LEU   A 1 875  ? 142.912 72.010  142.053 1.00 47.73  ?  875  LEU   C O     1 
ATOM   5299 C CB    . LEU   A 1 875  ? 142.661 75.270  142.306 1.00 40.56  ?  875  LEU   C CB    1 
ATOM   5300 C CG    . LEU   A 1 875  ? 143.349 76.624  142.009 1.00 39.19  ?  875  LEU   C CG    1 
ATOM   5301 C CD1   . LEU   A 1 875  ? 143.093 77.588  143.175 1.00 36.50  ?  875  LEU   C CD1   1 
ATOM   5302 C CD2   . LEU   A 1 875  ? 144.839 76.417  141.817 1.00 40.42  ?  875  LEU   C CD2   1 
ATOM   5303 N N     . CYS   A 1 876  ? 140.811 72.796  141.858 1.00 49.54  ?  876  CYS   C N     1 
ATOM   5304 C CA    . CYS   A 1 876  ? 140.171 71.609  142.402 1.00 51.93  ?  876  CYS   C CA    1 
ATOM   5305 C C     . CYS   A 1 876  ? 140.376 70.383  141.528 1.00 52.95  ?  876  CYS   C C     1 
ATOM   5306 O O     . CYS   A 1 876  ? 140.634 69.289  142.028 1.00 52.27  ?  876  CYS   C O     1 
ATOM   5307 C CB    . CYS   A 1 876  ? 138.679 71.839  142.566 1.00 55.47  ?  876  CYS   C CB    1 
ATOM   5308 S SG    . CYS   A 1 876  ? 138.252 73.007  143.861 1.00 55.51  ?  876  CYS   C SG    1 
ATOM   5309 N N     . GLU   A 1 877  ? 140.265 70.555  140.218 1.00 52.18  ?  877  GLU   C N     1 
ATOM   5310 C CA    . GLU   A 1 877  ? 140.395 69.415  139.324 1.00 55.80  ?  877  GLU   C CA    1 
ATOM   5311 C C     . GLU   A 1 877  ? 141.775 68.793  139.421 1.00 54.89  ?  877  GLU   C C     1 
ATOM   5312 O O     . GLU   A 1 877  ? 141.927 67.581  139.277 1.00 56.78  ?  877  GLU   C O     1 
ATOM   5313 C CB    . GLU   A 1 877  ? 140.082 69.809  137.883 1.00 58.77  ?  877  GLU   C CB    1 
ATOM   5314 C CG    . GLU   A 1 877  ? 138.595 70.029  137.622 1.00 59.94  ?  877  GLU   C CG    1 
ATOM   5315 C CD    . GLU   A 1 877  ? 137.779 68.794  137.917 1.00 68.81  ?  877  GLU   C CD    1 
ATOM   5316 O OE1   . GLU   A 1 877  ? 138.155 67.735  137.473 1.00 66.97  ?  877  GLU   C OE1   1 
ATOM   5317 O OE2   . GLU   A 1 877  ? 136.787 68.906  138.597 1.00 67.03  -1 877  GLU   C OE2   1 
ATOM   5318 N N     . LYS   A 1 878  ? 142.785 69.606  139.686 1.00 49.06  ?  878  LYS   C N     1 
ATOM   5319 C CA    . LYS   A 1 878  ? 144.115 69.060  139.883 1.00 48.09  ?  878  LYS   C CA    1 
ATOM   5320 C C     . LYS   A 1 878  ? 144.344 68.678  141.348 1.00 49.20  ?  878  LYS   C C     1 
ATOM   5321 O O     . LYS   A 1 878  ? 145.025 67.696  141.642 1.00 50.39  ?  878  LYS   C O     1 
ATOM   5322 C CB    . LYS   A 1 878  ? 145.174 70.059  139.422 1.00 49.37  ?  878  LYS   C CB    1 
ATOM   5323 C CG    . LYS   A 1 878  ? 145.163 70.386  137.918 1.00 50.62  ?  878  LYS   C CG    1 
ATOM   5324 C CD    . LYS   A 1 878  ? 145.492 69.176  137.056 1.00 51.82  ?  878  LYS   C CD    1 
ATOM   5325 C CE    . LYS   A 1 878  ? 145.654 69.575  135.591 1.00 53.30  ?  878  LYS   C CE    1 
ATOM   5326 N NZ    . LYS   A 1 878  ? 145.910 68.397  134.719 1.00 58.80  1  878  LYS   C NZ    1 
ATOM   5327 N N     . ALA   A 1 879  ? 143.756 69.444  142.270 1.00 46.87  ?  879  ALA   C N     1 
ATOM   5328 C CA    . ALA   A 1 879  ? 143.943 69.214  143.701 1.00 47.33  ?  879  ALA   C CA    1 
ATOM   5329 C C     . ALA   A 1 879  ? 143.230 67.954  144.172 1.00 51.98  ?  879  ALA   C C     1 
ATOM   5330 O O     . ALA   A 1 879  ? 143.632 67.353  145.167 1.00 52.15  ?  879  ALA   C O     1 
ATOM   5331 C CB    . ALA   A 1 879  ? 143.445 70.402  144.507 1.00 48.42  ?  879  ALA   C CB    1 
ATOM   5332 N N     . LYS   A 1 880  ? 142.181 67.546  143.459 1.00 53.49  ?  880  LYS   C N     1 
ATOM   5333 C CA    . LYS   A 1 880  ? 141.422 66.358  143.834 1.00 55.40  ?  880  LYS   C CA    1 
ATOM   5334 C C     . LYS   A 1 880  ? 142.273 65.101  143.700 1.00 52.94  ?  880  LYS   C C     1 
ATOM   5335 O O     . LYS   A 1 880  ? 141.927 64.058  144.241 1.00 52.71  ?  880  LYS   C O     1 
ATOM   5336 C CB    . LYS   A 1 880  ? 140.159 66.198  142.975 1.00 54.48  ?  880  LYS   C CB    1 
ATOM   5337 C CG    . LYS   A 1 880  ? 140.424 65.687  141.567 1.00 54.65  ?  880  LYS   C CG    1 
ATOM   5338 C CD    . LYS   A 1 880  ? 139.162 65.666  140.711 1.00 58.89  ?  880  LYS   C CD    1 
ATOM   5339 C CE    . LYS   A 1 880  ? 139.441 65.033  139.345 1.00 68.47  ?  880  LYS   C CE    1 
ATOM   5340 N NZ    . LYS   A 1 880  ? 138.254 65.082  138.440 1.00 67.70  1  880  LYS   C NZ    1 
ATOM   5341 N N     . ASN   A 1 881  ? 143.372 65.178  142.959 1.00 51.38  ?  881  ASN   C N     1 
ATOM   5342 C CA    . ASN   A 1 881  ? 144.207 64.005  142.769 1.00 50.28  ?  881  ASN   C CA    1 
ATOM   5343 C C     . ASN   A 1 881  ? 144.573 63.422  144.134 1.00 50.33  ?  881  ASN   C C     1 
ATOM   5344 O O     . ASN   A 1 881  ? 145.099 64.140  144.981 1.00 51.00  ?  881  ASN   C O     1 
ATOM   5345 C CB    . ASN   A 1 881  ? 145.458 64.357  141.982 1.00 52.84  ?  881  ASN   C CB    1 
ATOM   5346 C CG    . ASN   A 1 881  ? 146.278 63.146  141.590 1.00 55.80  ?  881  ASN   C CG    1 
ATOM   5347 O OD1   . ASN   A 1 881  ? 146.712 62.363  142.443 1.00 55.21  ?  881  ASN   C OD1   1 
ATOM   5348 N ND2   . ASN   A 1 881  ? 146.497 62.978  140.310 1.00 55.81  ?  881  ASN   C ND2   1 
ATOM   5349 N N     . PRO   A 1 882  ? 144.340 62.124  144.365 1.00 50.94  ?  882  PRO   C N     1 
ATOM   5350 C CA    . PRO   A 1 882  ? 144.531 61.427  145.625 1.00 54.87  ?  882  PRO   C CA    1 
ATOM   5351 C C     . PRO   A 1 882  ? 145.977 61.477  146.111 1.00 54.55  ?  882  PRO   C C     1 
ATOM   5352 O O     . PRO   A 1 882  ? 146.249 61.205  147.279 1.00 54.83  ?  882  PRO   C O     1 
ATOM   5353 C CB    . PRO   A 1 882  ? 144.091 59.995  145.286 1.00 55.44  ?  882  PRO   C CB    1 
ATOM   5354 C CG    . PRO   A 1 882  ? 144.217 59.887  143.786 1.00 54.12  ?  882  PRO   C CG    1 
ATOM   5355 C CD    . PRO   A 1 882  ? 143.869 61.258  143.270 1.00 52.28  ?  882  PRO   C CD    1 
ATOM   5356 N N     . GLN   A 1 883  ? 146.903 61.815  145.220 1.00 51.93  ?  883  GLN   C N     1 
ATOM   5357 C CA    . GLN   A 1 883  ? 148.311 61.901  145.583 1.00 52.78  ?  883  GLN   C CA    1 
ATOM   5358 C C     . GLN   A 1 883  ? 148.714 63.327  145.946 1.00 49.62  ?  883  GLN   C C     1 
ATOM   5359 O O     . GLN   A 1 883  ? 149.880 63.597  146.231 1.00 49.70  ?  883  GLN   C O     1 
ATOM   5360 C CB    . GLN   A 1 883  ? 149.187 61.383  144.444 1.00 56.49  ?  883  GLN   C CB    1 
ATOM   5361 C CG    . GLN   A 1 883  ? 148.915 59.940  144.075 1.00 58.05  ?  883  GLN   C CG    1 
ATOM   5362 C CD    . GLN   A 1 883  ? 149.114 59.004  145.242 1.00 60.05  ?  883  GLN   C CD    1 
ATOM   5363 O OE1   . GLN   A 1 883  ? 150.181 58.982  145.860 1.00 54.69  ?  883  GLN   C OE1   1 
ATOM   5364 N NE2   . GLN   A 1 883  ? 148.087 58.225  145.558 1.00 60.27  ?  883  GLN   C NE2   1 
ATOM   5365 N N     . CYS   A 1 884  ? 147.750 64.242  145.922 1.00 46.55  ?  884  CYS   C N     1 
ATOM   5366 C CA    . CYS   A 1 884  ? 147.995 65.633  146.278 1.00 46.63  ?  884  CYS   C CA    1 
ATOM   5367 C C     . CYS   A 1 884  ? 148.213 65.756  147.780 1.00 45.93  ?  884  CYS   C C     1 
ATOM   5368 O O     . CYS   A 1 884  ? 147.466 65.177  148.567 1.00 47.37  ?  884  CYS   C O     1 
ATOM   5369 C CB    . CYS   A 1 884  ? 146.817 66.512  145.857 1.00 47.70  ?  884  CYS   C CB    1 
ATOM   5370 S SG    . CYS   A 1 884  ? 147.044 68.271  146.196 1.00 49.30  ?  884  CYS   C SG    1 
ATOM   5371 N N     . ASN   A 1 885  ? 149.237 66.504  148.181 1.00 41.22  ?  885  ASN   C N     1 
ATOM   5372 C CA    . ASN   A 1 885  ? 149.541 66.659  149.599 1.00 38.62  ?  885  ASN   C CA    1 
ATOM   5373 C C     . ASN   A 1 885  ? 148.979 67.943  150.198 1.00 36.10  ?  885  ASN   C C     1 
ATOM   5374 O O     . ASN   A 1 885  ? 149.258 68.261  151.350 1.00 37.73  ?  885  ASN   C O     1 
ATOM   5375 C CB    . ASN   A 1 885  ? 151.037 66.576  149.839 1.00 38.06  ?  885  ASN   C CB    1 
ATOM   5376 C CG    . ASN   A 1 885  ? 151.573 65.182  149.632 1.00 42.54  ?  885  ASN   C CG    1 
ATOM   5377 O OD1   . ASN   A 1 885  ? 150.857 64.194  149.838 1.00 43.66  ?  885  ASN   C OD1   1 
ATOM   5378 N ND2   . ASN   A 1 885  ? 152.822 65.075  149.242 1.00 43.97  ?  885  ASN   C ND2   1 
ATOM   5379 N N     . LEU   A 1 886  ? 148.172 68.668  149.436 1.00 32.94  ?  886  LEU   C N     1 
ATOM   5380 C CA    . LEU   A 1 886  ? 147.619 69.922  149.933 1.00 30.27  ?  886  LEU   C CA    1 
ATOM   5381 C C     . LEU   A 1 886  ? 146.845 69.701  151.219 1.00 34.69  ?  886  LEU   C C     1 
ATOM   5382 O O     . LEU   A 1 886  ? 145.923 68.890  151.263 1.00 39.59  ?  886  LEU   C O     1 
ATOM   5383 C CB    . LEU   A 1 886  ? 146.690 70.540  148.880 1.00 30.30  ?  886  LEU   C CB    1 
ATOM   5384 C CG    . LEU   A 1 886  ? 146.013 71.881  149.244 1.00 29.47  ?  886  LEU   C CG    1 
ATOM   5385 C CD1   . LEU   A 1 886  ? 147.061 72.976  149.363 1.00 31.58  ?  886  LEU   C CD1   1 
ATOM   5386 C CD2   . LEU   A 1 886  ? 144.992 72.229  148.167 1.00 31.06  ?  886  LEU   C CD2   1 
ATOM   5387 N N     . GLN   A 1 887  ? 147.217 70.448  152.260 1.00 30.74  ?  887  GLN   C N     1 
ATOM   5388 C CA    . GLN   A 1 887  ? 146.586 70.333  153.569 1.00 30.52  ?  887  GLN   C CA    1 
ATOM   5389 C C     . GLN   A 1 887  ? 145.676 71.506  153.884 1.00 29.45  ?  887  GLN   C C     1 
ATOM   5390 O O     . GLN   A 1 887  ? 144.602 71.323  154.464 1.00 35.91  ?  887  GLN   C O     1 
ATOM   5391 C CB    . GLN   A 1 887  ? 147.644 70.217  154.667 1.00 29.73  ?  887  GLN   C CB    1 
ATOM   5392 C CG    . GLN   A 1 887  ? 148.472 68.956  154.595 1.00 33.21  ?  887  GLN   C CG    1 
ATOM   5393 C CD    . GLN   A 1 887  ? 149.512 68.874  155.688 1.00 38.02  ?  887  GLN   C CD    1 
ATOM   5394 O OE1   . GLN   A 1 887  ? 149.405 69.533  156.726 1.00 36.73  ?  887  GLN   C OE1   1 
ATOM   5395 N NE2   . GLN   A 1 887  ? 150.534 68.058  155.463 1.00 38.78  ?  887  GLN   C NE2   1 
ATOM   5396 N N     . LYS   A 1 888  ? 146.097 72.708  153.505 1.00 23.87  ?  888  LYS   C N     1 
ATOM   5397 C CA    . LYS   A 1 888  ? 145.284 73.884  153.783 1.00 22.02  ?  888  LYS   C CA    1 
ATOM   5398 C C     . LYS   A 1 888  ? 144.982 74.660  152.516 1.00 21.96  ?  888  LYS   C C     1 
ATOM   5399 O O     . LYS   A 1 888  ? 145.889 75.095  151.804 1.00 27.40  ?  888  LYS   C O     1 
ATOM   5400 C CB    . LYS   A 1 888  ? 145.976 74.813  154.772 1.00 30.02  ?  888  LYS   C CB    1 
ATOM   5401 C CG    . LYS   A 1 888  ? 146.338 74.183  156.108 1.00 34.93  ?  888  LYS   C CG    1 
ATOM   5402 C CD    . LYS   A 1 888  ? 146.778 75.243  157.100 1.00 35.95  ?  888  LYS   C CD    1 
ATOM   5403 C CE    . LYS   A 1 888  ? 147.040 74.652  158.471 1.00 40.32  ?  888  LYS   C CE    1 
ATOM   5404 N NZ    . LYS   A 1 888  ? 147.493 75.688  159.435 1.00 46.88  1  888  LYS   C NZ    1 
ATOM   5405 N N     . LEU   A 1 889  ? 143.701 74.856  152.252 1.00 21.64  ?  889  LEU   C N     1 
ATOM   5406 C CA    . LEU   A 1 889  ? 143.282 75.606  151.081 1.00 18.83  ?  889  LEU   C CA    1 
ATOM   5407 C C     . LEU   A 1 889  ? 142.692 76.950  151.492 1.00 18.06  ?  889  LEU   C C     1 
ATOM   5408 O O     . LEU   A 1 889  ? 141.529 77.051  151.891 1.00 30.39  ?  889  LEU   C O     1 
ATOM   5409 C CB    . LEU   A 1 889  ? 142.290 74.757  150.279 1.00 28.13  ?  889  LEU   C CB    1 
ATOM   5410 C CG    . LEU   A 1 889  ? 141.669 75.381  149.043 1.00 25.76  ?  889  LEU   C CG    1 
ATOM   5411 C CD1   . LEU   A 1 889  ? 142.758 75.852  148.073 1.00 26.23  ?  889  LEU   C CD1   1 
ATOM   5412 C CD2   . LEU   A 1 889  ? 140.779 74.338  148.375 1.00 31.89  ?  889  LEU   C CD2   1 
ATOM   5413 N N     . GLY   A 1 890  ? 143.525 77.981  151.432 1.00 18.27  ?  890  GLY   C N     1 
ATOM   5414 C CA    . GLY   A 1 890  ? 143.192 79.296  151.973 1.00 22.81  ?  890  GLY   C CA    1 
ATOM   5415 C C     . GLY   A 1 890  ? 142.437 80.189  151.000 1.00 23.85  ?  890  GLY   C C     1 
ATOM   5416 O O     . GLY   A 1 890  ? 142.895 81.288  150.672 1.00 26.25  ?  890  GLY   C O     1 
ATOM   5417 N N     . LEU   A 1 891  ? 141.266 79.753  150.569 1.00 20.51  ?  891  LEU   C N     1 
ATOM   5418 C CA    . LEU   A 1 891  ? 140.454 80.544  149.649 1.00 19.00  ?  891  LEU   C CA    1 
ATOM   5419 C C     . LEU   A 1 891  ? 139.626 81.542  150.432 1.00 22.06  ?  891  LEU   C C     1 
ATOM   5420 O O     . LEU   A 1 891  ? 138.399 81.572  150.331 1.00 29.27  ?  891  LEU   C O     1 
ATOM   5421 C CB    . LEU   A 1 891  ? 139.546 79.623  148.841 1.00 20.89  ?  891  LEU   C CB    1 
ATOM   5422 C CG    . LEU   A 1 891  ? 140.264 78.612  147.972 1.00 21.57  ?  891  LEU   C CG    1 
ATOM   5423 C CD1   . LEU   A 1 891  ? 139.296 77.558  147.524 1.00 28.29  ?  891  LEU   C CD1   1 
ATOM   5424 C CD2   . LEU   A 1 891  ? 140.850 79.308  146.775 1.00 24.51  ?  891  LEU   C CD2   1 
ATOM   5425 N N     . VAL   A 1 892  ? 140.314 82.368  151.211 1.00 21.44  ?  892  VAL   C N     1 
ATOM   5426 C CA    . VAL   A 1 892  ? 139.673 83.266  152.162 1.00 25.02  ?  892  VAL   C CA    1 
ATOM   5427 C C     . VAL   A 1 892  ? 138.680 84.188  151.496 1.00 26.13  ?  892  VAL   C C     1 
ATOM   5428 O O     . VAL   A 1 892  ? 137.583 84.407  151.999 1.00 32.96  ?  892  VAL   C O     1 
ATOM   5429 C CB    . VAL   A 1 892  ? 140.738 84.113  152.885 1.00 29.84  ?  892  VAL   C CB    1 
ATOM   5430 C CG1   . VAL   A 1 892  ? 140.071 85.201  153.720 1.00 32.29  ?  892  VAL   C CG1   1 
ATOM   5431 C CG2   . VAL   A 1 892  ? 141.592 83.201  153.770 1.00 34.76  ?  892  VAL   C CG2   1 
ATOM   5432 N N     . ASN   A 1 893  ? 139.069 84.750  150.380 1.00 22.68  ?  893  ASN   C N     1 
ATOM   5433 C CA    . ASN   A 1 893  ? 138.194 85.649  149.665 1.00 24.96  ?  893  ASN   C CA    1 
ATOM   5434 C C     . ASN   A 1 893  ? 138.482 85.537  148.189 1.00 28.58  ?  893  ASN   C C     1 
ATOM   5435 O O     . ASN   A 1 893  ? 139.350 86.235  147.668 1.00 32.15  ?  893  ASN   C O     1 
ATOM   5436 C CB    . ASN   A 1 893  ? 138.361 87.069  150.165 1.00 25.15  ?  893  ASN   C CB    1 
ATOM   5437 C CG    . ASN   A 1 893  ? 137.372 88.002  149.557 1.00 23.59  ?  893  ASN   C CG    1 
ATOM   5438 O OD1   . ASN   A 1 893  ? 136.407 87.551  148.930 1.00 25.02  ?  893  ASN   C OD1   1 
ATOM   5439 N ND2   . ASN   A 1 893  ? 137.583 89.286  149.719 1.00 26.55  ?  893  ASN   C ND2   1 
ATOM   5440 N N     . SER   A 1 894  ? 137.822 84.597  147.537 1.00 26.67  ?  894  SER   C N     1 
ATOM   5441 C CA    . SER   A 1 894  ? 138.125 84.293  146.156 1.00 27.29  ?  894  SER   C CA    1 
ATOM   5442 C C     . SER   A 1 894  ? 136.932 84.544  145.258 1.00 30.52  ?  894  SER   C C     1 
ATOM   5443 O O     . SER   A 1 894  ? 136.912 84.117  144.106 1.00 36.34  ?  894  SER   C O     1 
ATOM   5444 C CB    . SER   A 1 894  ? 138.595 82.863  146.049 1.00 31.37  ?  894  SER   C CB    1 
ATOM   5445 O OG    . SER   A 1 894  ? 139.787 82.682  146.758 1.00 28.82  ?  894  SER   C OG    1 
ATOM   5446 N N     . GLY   A 1 895  ? 135.915 85.202  145.798 1.00 29.60  ?  895  GLY   C N     1 
ATOM   5447 C CA    . GLY   A 1 895  ? 134.741 85.534  145.008 1.00 32.92  ?  895  GLY   C CA    1 
ATOM   5448 C C     . GLY   A 1 895  ? 134.001 84.281  144.578 1.00 32.89  ?  895  GLY   C C     1 
ATOM   5449 O O     . GLY   A 1 895  ? 133.458 84.221  143.474 1.00 38.63  ?  895  GLY   C O     1 
ATOM   5450 N N     . LEU   A 1 896  ? 134.004 83.264  145.423 1.00 29.95  ?  896  LEU   C N     1 
ATOM   5451 C CA    . LEU   A 1 896  ? 133.393 82.011  145.029 1.00 32.77  ?  896  LEU   C CA    1 
ATOM   5452 C C     . LEU   A 1 896  ? 131.889 82.038  145.167 1.00 42.66  ?  896  LEU   C C     1 
ATOM   5453 O O     . LEU   A 1 896  ? 131.336 82.682  146.061 1.00 45.37  ?  896  LEU   C O     1 
ATOM   5454 C CB    . LEU   A 1 896  ? 133.958 80.857  145.844 1.00 31.53  ?  896  LEU   C CB    1 
ATOM   5455 C CG    . LEU   A 1 896  ? 135.452 80.678  145.767 1.00 31.89  ?  896  LEU   C CG    1 
ATOM   5456 C CD1   . LEU   A 1 896  ? 135.830 79.421  146.510 1.00 32.47  ?  896  LEU   C CD1   1 
ATOM   5457 C CD2   . LEU   A 1 896  ? 135.915 80.638  144.318 1.00 40.74  ?  896  LEU   C CD2   1 
ATOM   5458 N N     . THR   A 1 897  ? 131.239 81.307  144.276 1.00 44.66  ?  897  THR   C N     1 
ATOM   5459 C CA    . THR   A 1 897  ? 129.794 81.168  144.257 1.00 46.17  ?  897  THR   C CA    1 
ATOM   5460 C C     . THR   A 1 897  ? 129.376 79.713  144.403 1.00 49.28  ?  897  THR   C C     1 
ATOM   5461 O O     . THR   A 1 897  ? 130.215 78.824  144.538 1.00 52.67  ?  897  THR   C O     1 
ATOM   5462 C CB    . THR   A 1 897  ? 129.208 81.747  142.965 1.00 52.69  ?  897  THR   C CB    1 
ATOM   5463 O OG1   . THR   A 1 897  ? 127.778 81.774  143.069 1.00 51.94  ?  897  THR   C OG1   1 
ATOM   5464 C CG2   . THR   A 1 897  ? 129.636 80.903  141.761 1.00 58.01  ?  897  THR   C CG2   1 
ATOM   5465 N N     . SER   A 1 898  ? 128.069 79.484  144.392 1.00 48.42  ?  898  SER   C N     1 
ATOM   5466 C CA    . SER   A 1 898  ? 127.519 78.152  144.614 1.00 53.89  ?  898  SER   C CA    1 
ATOM   5467 C C     . SER   A 1 898  ? 127.860 77.190  143.487 1.00 55.38  ?  898  SER   C C     1 
ATOM   5468 O O     . SER   A 1 898  ? 128.036 75.993  143.707 1.00 58.54  ?  898  SER   C O     1 
ATOM   5469 C CB    . SER   A 1 898  ? 126.015 78.247  144.749 1.00 55.14  ?  898  SER   C CB    1 
ATOM   5470 O OG    . SER   A 1 898  ? 125.437 78.678  143.547 1.00 55.83  ?  898  SER   C OG    1 
ATOM   5471 N N     . VAL   A 1 899  ? 127.999 77.723  142.283 1.00 52.41  ?  899  VAL   C N     1 
ATOM   5472 C CA    . VAL   A 1 899  ? 128.256 76.915  141.097 1.00 56.27  ?  899  VAL   C CA    1 
ATOM   5473 C C     . VAL   A 1 899  ? 129.543 76.118  141.210 1.00 58.41  ?  899  VAL   C C     1 
ATOM   5474 O O     . VAL   A 1 899  ? 129.610 74.965  140.786 1.00 61.73  ?  899  VAL   C O     1 
ATOM   5475 C CB    . VAL   A 1 899  ? 128.331 77.821  139.851 1.00 57.82  ?  899  VAL   C CB    1 
ATOM   5476 C CG1   . VAL   A 1 899  ? 128.803 77.023  138.632 1.00 55.69  ?  899  VAL   C CG1   1 
ATOM   5477 C CG2   . VAL   A 1 899  ? 126.961 78.423  139.587 1.00 62.68  ?  899  VAL   C CG2   1 
ATOM   5478 N N     . CYS   A 1 900  ? 130.575 76.740  141.755 1.00 57.30  ?  900  CYS   C N     1 
ATOM   5479 C CA    . CYS   A 1 900  ? 131.884 76.111  141.848 1.00 59.13  ?  900  CYS   C CA    1 
ATOM   5480 C C     . CYS   A 1 900  ? 131.989 75.181  143.045 1.00 58.28  ?  900  CYS   C C     1 
ATOM   5481 O O     . CYS   A 1 900  ? 133.000 74.499  143.227 1.00 56.49  ?  900  CYS   C O     1 
ATOM   5482 C CB    . CYS   A 1 900  ? 132.961 77.164  141.984 1.00 61.54  ?  900  CYS   C CB    1 
ATOM   5483 S SG    . CYS   A 1 900  ? 132.981 77.960  143.597 1.00 63.46  ?  900  CYS   C SG    1 
ATOM   5484 N N     . CYS   A 1 901  ? 130.969 75.185  143.884 1.00 56.49  ?  901  CYS   C N     1 
ATOM   5485 C CA    . CYS   A 1 901  ? 131.035 74.436  145.121 1.00 58.55  ?  901  CYS   C CA    1 
ATOM   5486 C C     . CYS   A 1 901  ? 131.230 72.956  144.864 1.00 59.47  ?  901  CYS   C C     1 
ATOM   5487 O O     . CYS   A 1 901  ? 131.910 72.273  145.631 1.00 58.63  ?  901  CYS   C O     1 
ATOM   5488 C CB    . CYS   A 1 901  ? 129.793 74.632  145.964 1.00 62.45  ?  901  CYS   C CB    1 
ATOM   5489 S SG    . CYS   A 1 901  ? 129.961 73.902  147.571 1.00 74.75  ?  901  CYS   C SG    1 
ATOM   5490 N N     . SER   A 1 902  ? 130.635 72.449  143.790 1.00 58.68  ?  902  SER   C N     1 
ATOM   5491 C CA    . SER   A 1 902  ? 130.736 71.035  143.478 1.00 59.30  ?  902  SER   C CA    1 
ATOM   5492 C C     . SER   A 1 902  ? 132.190 70.627  143.247 1.00 59.46  ?  902  SER   C C     1 
ATOM   5493 O O     . SER   A 1 902  ? 132.550 69.461  143.430 1.00 60.08  ?  902  SER   C O     1 
ATOM   5494 C CB    . SER   A 1 902  ? 129.910 70.712  142.252 1.00 57.50  ?  902  SER   C CB    1 
ATOM   5495 O OG    . SER   A 1 902  ? 130.469 71.301  141.108 1.00 56.17  ?  902  SER   C OG    1 
ATOM   5496 N N     . ALA   A 1 903  ? 133.028 71.583  142.850 1.00 55.93  ?  903  ALA   C N     1 
ATOM   5497 C CA    . ALA   A 1 903  ? 134.432 71.295  142.636 1.00 59.35  ?  903  ALA   C CA    1 
ATOM   5498 C C     . ALA   A 1 903  ? 135.117 71.093  143.977 1.00 56.41  ?  903  ALA   C C     1 
ATOM   5499 O O     . ALA   A 1 903  ? 135.961 70.208  144.134 1.00 56.68  ?  903  ALA   C O     1 
ATOM   5500 C CB    . ALA   A 1 903  ? 135.084 72.422  141.862 1.00 61.85  ?  903  ALA   C CB    1 
ATOM   5501 N N     . LEU   A 1 904  ? 134.719 71.906  144.951 1.00 54.03  ?  904  LEU   C N     1 
ATOM   5502 C CA    . LEU   A 1 904  ? 135.273 71.803  146.291 1.00 53.96  ?  904  LEU   C CA    1 
ATOM   5503 C C     . LEU   A 1 904  ? 134.853 70.484  146.911 1.00 56.67  ?  904  LEU   C C     1 
ATOM   5504 O O     . LEU   A 1 904  ? 135.630 69.843  147.618 1.00 55.59  ?  904  LEU   C O     1 
ATOM   5505 C CB    . LEU   A 1 904  ? 134.794 72.968  147.171 1.00 52.57  ?  904  LEU   C CB    1 
ATOM   5506 C CG    . LEU   A 1 904  ? 135.336 74.372  146.815 1.00 49.01  ?  904  LEU   C CG    1 
ATOM   5507 C CD1   . LEU   A 1 904  ? 134.570 75.422  147.615 1.00 50.76  ?  904  LEU   C CD1   1 
ATOM   5508 C CD2   . LEU   A 1 904  ? 136.824 74.450  147.141 1.00 46.01  ?  904  LEU   C CD2   1 
ATOM   5509 N N     . SER   A 1 905  ? 133.623 70.073  146.618 1.00 55.57  ?  905  SER   C N     1 
ATOM   5510 C CA    . SER   A 1 905  ? 133.094 68.820  147.134 1.00 57.95  ?  905  SER   C CA    1 
ATOM   5511 C C     . SER   A 1 905  ? 133.923 67.637  146.656 1.00 56.40  ?  905  SER   C C     1 
ATOM   5512 O O     . SER   A 1 905  ? 134.295 66.768  147.450 1.00 55.54  ?  905  SER   C O     1 
ATOM   5513 C CB    . SER   A 1 905  ? 131.653 68.647  146.710 1.00 63.35  ?  905  SER   C CB    1 
ATOM   5514 O OG    . SER   A 1 905  ? 131.145 67.424  147.156 1.00 69.07  ?  905  SER   C OG    1 
ATOM   5515 N N     . SER   A 1 906  ? 134.245 67.620  145.364 1.00 55.06  ?  906  SER   C N     1 
ATOM   5516 C CA    . SER   A 1 906  ? 135.046 66.539  144.804 1.00 59.15  ?  906  SER   C CA    1 
ATOM   5517 C C     . SER   A 1 906  ? 136.407 66.450  145.483 1.00 59.14  ?  906  SER   C C     1 
ATOM   5518 O O     . SER   A 1 906  ? 136.915 65.354  145.734 1.00 58.50  ?  906  SER   C O     1 
ATOM   5519 C CB    . SER   A 1 906  ? 135.235 66.742  143.314 1.00 63.09  ?  906  SER   C CB    1 
ATOM   5520 O OG    . SER   A 1 906  ? 134.022 66.605  142.627 1.00 62.49  ?  906  SER   C OG    1 
ATOM   5521 N N     . VAL   A 1 907  ? 137.000 67.599  145.796 1.00 57.04  ?  907  VAL   C N     1 
ATOM   5522 C CA    . VAL   A 1 907  ? 138.293 67.592  146.468 1.00 54.72  ?  907  VAL   C CA    1 
ATOM   5523 C C     . VAL   A 1 907  ? 138.163 67.070  147.892 1.00 54.28  ?  907  VAL   C C     1 
ATOM   5524 O O     . VAL   A 1 907  ? 138.959 66.241  148.331 1.00 54.98  ?  907  VAL   C O     1 
ATOM   5525 C CB    . VAL   A 1 907  ? 138.908 69.001  146.502 1.00 51.86  ?  907  VAL   C CB    1 
ATOM   5526 C CG1   . VAL   A 1 907  ? 140.185 68.995  147.339 1.00 51.69  ?  907  VAL   C CG1   1 
ATOM   5527 C CG2   . VAL   A 1 907  ? 139.207 69.449  145.105 1.00 55.10  ?  907  VAL   C CG2   1 
ATOM   5528 N N     . LEU   A 1 908  ? 137.155 67.538  148.617 1.00 52.44  ?  908  LEU   C N     1 
ATOM   5529 C CA    . LEU   A 1 908  ? 136.981 67.149  150.011 1.00 51.96  ?  908  LEU   C CA    1 
ATOM   5530 C C     . LEU   A 1 908  ? 136.825 65.649  150.193 1.00 56.76  ?  908  LEU   C C     1 
ATOM   5531 O O     . LEU   A 1 908  ? 137.352 65.077  151.148 1.00 58.46  ?  908  LEU   C O     1 
ATOM   5532 C CB    . LEU   A 1 908  ? 135.745 67.845  150.587 1.00 50.43  ?  908  LEU   C CB    1 
ATOM   5533 C CG    . LEU   A 1 908  ? 135.870 69.336  150.861 1.00 47.30  ?  908  LEU   C CG    1 
ATOM   5534 C CD1   . LEU   A 1 908  ? 134.490 69.905  151.092 1.00 54.59  ?  908  LEU   C CD1   1 
ATOM   5535 C CD2   . LEU   A 1 908  ? 136.736 69.550  152.095 1.00 47.52  ?  908  LEU   C CD2   1 
ATOM   5536 N N     . SER   A 1 909  ? 136.115 65.006  149.276 1.00 57.98  ?  909  SER   C N     1 
ATOM   5537 C CA    . SER   A 1 909  ? 135.884 63.571  149.373 1.00 61.48  ?  909  SER   C CA    1 
ATOM   5538 C C     . SER   A 1 909  ? 137.018 62.736  148.778 1.00 60.45  ?  909  SER   C C     1 
ATOM   5539 O O     . SER   A 1 909  ? 136.974 61.506  148.835 1.00 62.73  ?  909  SER   C O     1 
ATOM   5540 C CB    . SER   A 1 909  ? 134.575 63.211  148.697 1.00 63.13  ?  909  SER   C CB    1 
ATOM   5541 O OG    . SER   A 1 909  ? 134.635 63.429  147.317 1.00 60.57  ?  909  SER   C OG    1 
ATOM   5542 N N     . THR   A 1 910  ? 138.013 63.387  148.175 1.00 58.06  ?  910  THR   C N     1 
ATOM   5543 C CA    . THR   A 1 910  ? 139.072 62.647  147.495 1.00 61.69  ?  910  THR   C CA    1 
ATOM   5544 C C     . THR   A 1 910  ? 140.446 62.861  148.134 1.00 61.34  ?  910  THR   C C     1 
ATOM   5545 O O     . THR   A 1 910  ? 141.242 61.925  148.239 1.00 60.42  ?  910  THR   C O     1 
ATOM   5546 C CB    . THR   A 1 910  ? 139.151 63.037  146.004 1.00 64.26  ?  910  THR   C CB    1 
ATOM   5547 O OG1   . THR   A 1 910  ? 137.858 62.904  145.397 1.00 62.56  ?  910  THR   C OG1   1 
ATOM   5548 C CG2   . THR   A 1 910  ? 140.123 62.113  145.285 1.00 62.94  ?  910  THR   C CG2   1 
ATOM   5549 N N     . ASN   A 1 911  ? 140.729 64.091  148.549 1.00 58.69  ?  911  ASN   C N     1 
ATOM   5550 C CA    . ASN   A 1 911  ? 142.028 64.435  149.114 1.00 54.14  ?  911  ASN   C CA    1 
ATOM   5551 C C     . ASN   A 1 911  ? 142.086 64.104  150.599 1.00 51.19  ?  911  ASN   C C     1 
ATOM   5552 O O     . ASN   A 1 911  ? 141.555 64.833  151.435 1.00 50.80  ?  911  ASN   C O     1 
ATOM   5553 C CB    . ASN   A 1 911  ? 142.340 65.905  148.884 1.00 51.78  ?  911  ASN   C CB    1 
ATOM   5554 C CG    . ASN   A 1 911  ? 143.694 66.299  149.418 1.00 51.08  ?  911  ASN   C CG    1 
ATOM   5555 O OD1   . ASN   A 1 911  ? 144.373 65.489  150.059 1.00 48.68  ?  911  ASN   C OD1   1 
ATOM   5556 N ND2   . ASN   A 1 911  ? 144.088 67.526  149.187 1.00 48.28  ?  911  ASN   C ND2   1 
ATOM   5557 N N     . GLN   A 1 912  ? 142.761 63.008  150.929 1.00 50.39  ?  912  GLN   C N     1 
ATOM   5558 C CA    . GLN   A 1 912  ? 142.815 62.522  152.302 1.00 52.17  ?  912  GLN   C CA    1 
ATOM   5559 C C     . GLN   A 1 912  ? 143.743 63.370  153.150 1.00 51.11  ?  912  GLN   C C     1 
ATOM   5560 O O     . GLN   A 1 912  ? 143.819 63.200  154.366 1.00 53.09  ?  912  GLN   C O     1 
ATOM   5561 C CB    . GLN   A 1 912  ? 143.282 61.064  152.338 1.00 54.05  ?  912  GLN   C CB    1 
ATOM   5562 C CG    . GLN   A 1 912  ? 142.324 60.087  151.689 1.00 59.37  ?  912  GLN   C CG    1 
ATOM   5563 C CD    . GLN   A 1 912  ? 141.007 60.035  152.415 1.00 65.07  ?  912  GLN   C CD    1 
ATOM   5564 O OE1   . GLN   A 1 912  ? 140.966 59.777  153.625 1.00 63.35  ?  912  GLN   C OE1   1 
ATOM   5565 N NE2   . GLN   A 1 912  ? 139.925 60.287  151.698 1.00 65.58  ?  912  GLN   C NE2   1 
ATOM   5566 N N     . ASN   A 1 913  ? 144.466 64.269  152.501 1.00 46.18  ?  913  ASN   C N     1 
ATOM   5567 C CA    . ASN   A 1 913  ? 145.400 65.130  153.195 1.00 45.47  ?  913  ASN   C CA    1 
ATOM   5568 C C     . ASN   A 1 913  ? 144.823 66.513  153.455 1.00 43.37  ?  913  ASN   C C     1 
ATOM   5569 O O     . ASN   A 1 913  ? 145.494 67.350  154.050 1.00 42.63  ?  913  ASN   C O     1 
ATOM   5570 C CB    . ASN   A 1 913  ? 146.689 65.257  152.406 1.00 46.31  ?  913  ASN   C CB    1 
ATOM   5571 C CG    . ASN   A 1 913  ? 147.459 63.977  152.335 1.00 50.89  ?  913  ASN   C CG    1 
ATOM   5572 O OD1   . ASN   A 1 913  ? 147.633 63.279  153.342 1.00 49.54  ?  913  ASN   C OD1   1 
ATOM   5573 N ND2   . ASN   A 1 913  ? 147.929 63.646  151.158 1.00 50.69  ?  913  ASN   C ND2   1 
ATOM   5574 N N     . LEU   A 1 914  ? 143.584 66.762  153.030 1.00 41.79  ?  914  LEU   C N     1 
ATOM   5575 C CA    . LEU   A 1 914  ? 143.015 68.099  153.194 1.00 37.78  ?  914  LEU   C CA    1 
ATOM   5576 C C     . LEU   A 1 914  ? 142.313 68.219  154.530 1.00 38.79  ?  914  LEU   C C     1 
ATOM   5577 O O     . LEU   A 1 914  ? 141.300 67.564  154.776 1.00 44.59  ?  914  LEU   C O     1 
ATOM   5578 C CB    . LEU   A 1 914  ? 142.042 68.420  152.049 1.00 35.24  ?  914  LEU   C CB    1 
ATOM   5579 C CG    . LEU   A 1 914  ? 141.283 69.772  152.131 1.00 34.77  ?  914  LEU   C CG    1 
ATOM   5580 C CD1   . LEU   A 1 914  ? 142.265 70.933  152.124 1.00 37.02  ?  914  LEU   C CD1   1 
ATOM   5581 C CD2   . LEU   A 1 914  ? 140.350 69.876  150.941 1.00 46.84  ?  914  LEU   C CD2   1 
ATOM   5582 N N     . THR   A 1 915  ? 142.874 69.044  155.405 1.00 36.65  ?  915  THR   C N     1 
ATOM   5583 C CA    . THR   A 1 915  ? 142.372 69.150  156.763 1.00 38.52  ?  915  THR   C CA    1 
ATOM   5584 C C     . THR   A 1 915  ? 141.753 70.505  157.079 1.00 38.70  ?  915  THR   C C     1 
ATOM   5585 O O     . THR   A 1 915  ? 140.927 70.600  157.988 1.00 43.12  ?  915  THR   C O     1 
ATOM   5586 C CB    . THR   A 1 915  ? 143.491 68.836  157.770 1.00 40.61  ?  915  THR   C CB    1 
ATOM   5587 O OG1   . THR   A 1 915  ? 144.582 69.747  157.582 1.00 40.07  ?  915  THR   C OG1   1 
ATOM   5588 C CG2   . THR   A 1 915  ? 143.982 67.410  157.563 1.00 41.44  ?  915  THR   C CG2   1 
ATOM   5589 N N     . HIS   A 1 916  ? 142.109 71.539  156.320 1.00 32.67  ?  916  HIS   C N     1 
ATOM   5590 C CA    . HIS   A 1 916  ? 141.570 72.871  156.588 1.00 31.58  ?  916  HIS   C CA    1 
ATOM   5591 C C     . HIS   A 1 916  ? 141.070 73.563  155.322 1.00 30.29  ?  916  HIS   C C     1 
ATOM   5592 O O     . HIS   A 1 916  ? 141.803 73.697  154.340 1.00 36.21  ?  916  HIS   C O     1 
ATOM   5593 C CB    . HIS   A 1 916  ? 142.635 73.766  157.230 1.00 35.21  ?  916  HIS   C CB    1 
ATOM   5594 C CG    . HIS   A 1 916  ? 143.184 73.287  158.548 1.00 39.28  ?  916  HIS   C CG    1 
ATOM   5595 N ND1   . HIS   A 1 916  ? 144.029 72.199  158.662 1.00 40.53  ?  916  HIS   C ND1   1 
ATOM   5596 C CD2   . HIS   A 1 916  ? 143.031 73.774  159.798 1.00 42.14  ?  916  HIS   C CD2   1 
ATOM   5597 C CE1   . HIS   A 1 916  ? 144.351 72.030  159.933 1.00 44.54  ?  916  HIS   C CE1   1 
ATOM   5598 N NE2   . HIS   A 1 916  ? 143.762 72.973  160.640 1.00 47.26  ?  916  HIS   C NE2   1 
ATOM   5599 N N     . LEU   A 1 917  ? 139.828 74.033  155.365 1.00 28.42  ?  917  LEU   C N     1 
ATOM   5600 C CA    . LEU   A 1 917  ? 139.246 74.776  154.252 1.00 23.47  ?  917  LEU   C CA    1 
ATOM   5601 C C     . LEU   A 1 917  ? 138.726 76.127  154.724 1.00 26.13  ?  917  LEU   C C     1 
ATOM   5602 O O     . LEU   A 1 917  ? 137.872 76.198  155.610 1.00 37.12  ?  917  LEU   C O     1 
ATOM   5603 C CB    . LEU   A 1 917  ? 138.107 73.969  153.611 1.00 28.41  ?  917  LEU   C CB    1 
ATOM   5604 C CG    . LEU   A 1 917  ? 137.309 74.678  152.493 1.00 29.79  ?  917  LEU   C CG    1 
ATOM   5605 C CD1   . LEU   A 1 917  ? 138.224 74.969  151.311 1.00 31.33  ?  917  LEU   C CD1   1 
ATOM   5606 C CD2   . LEU   A 1 917  ? 136.147 73.784  152.062 1.00 44.60  ?  917  LEU   C CD2   1 
ATOM   5607 N N     . TYR   A 1 918  ? 139.249 77.196  154.138 1.00 24.15  ?  918  TYR   C N     1 
ATOM   5608 C CA    . TYR   A 1 918  ? 138.872 78.538  154.556 1.00 25.78  ?  918  TYR   C CA    1 
ATOM   5609 C C     . TYR   A 1 918  ? 138.101 79.262  153.472 1.00 27.70  ?  918  TYR   C C     1 
ATOM   5610 O O     . TYR   A 1 918  ? 138.639 79.519  152.399 1.00 31.61  ?  918  TYR   C O     1 
ATOM   5611 C CB    . TYR   A 1 918  ? 140.116 79.354  154.896 1.00 27.82  ?  918  TYR   C CB    1 
ATOM   5612 C CG    . TYR   A 1 918  ? 140.960 78.759  155.976 1.00 29.14  ?  918  TYR   C CG    1 
ATOM   5613 C CD1   . TYR   A 1 918  ? 141.951 77.840  155.662 1.00 31.05  ?  918  TYR   C CD1   1 
ATOM   5614 C CD2   . TYR   A 1 918  ? 140.755 79.133  157.277 1.00 33.29  ?  918  TYR   C CD2   1 
ATOM   5615 C CE1   . TYR   A 1 918  ? 142.727 77.304  156.664 1.00 33.85  ?  918  TYR   C CE1   1 
ATOM   5616 C CE2   . TYR   A 1 918  ? 141.524 78.596  158.278 1.00 33.20  ?  918  TYR   C CE2   1 
ATOM   5617 C CZ    . TYR   A 1 918  ? 142.507 77.689  157.979 1.00 33.70  ?  918  TYR   C CZ    1 
ATOM   5618 O OH    . TYR   A 1 918  ? 143.269 77.159  158.989 1.00 36.83  ?  918  TYR   C OH    1 
ATOM   5619 N N     . LEU   A 1 919  ? 136.851 79.600  153.759 1.00 26.11  ?  919  LEU   C N     1 
ATOM   5620 C CA    . LEU   A 1 919  ? 136.014 80.313  152.805 1.00 24.09  ?  919  LEU   C CA    1 
ATOM   5621 C C     . LEU   A 1 919  ? 135.505 81.610  153.426 1.00 27.37  ?  919  LEU   C C     1 
ATOM   5622 O O     . LEU   A 1 919  ? 134.383 82.050  153.165 1.00 31.79  ?  919  LEU   C O     1 
ATOM   5623 C CB    . LEU   A 1 919  ? 134.844 79.421  152.369 1.00 27.02  ?  919  LEU   C CB    1 
ATOM   5624 C CG    . LEU   A 1 919  ? 135.228 78.077  151.680 1.00 26.07  ?  919  LEU   C CG    1 
ATOM   5625 C CD1   . LEU   A 1 919  ? 133.974 77.234  151.487 1.00 34.78  ?  919  LEU   C CD1   1 
ATOM   5626 C CD2   . LEU   A 1 919  ? 135.895 78.350  150.350 1.00 28.42  ?  919  LEU   C CD2   1 
ATOM   5627 N N     . ARG   A 1 920  ? 136.338 82.209  154.269 1.00 28.87  ?  920  ARG   C N     1 
ATOM   5628 C CA    . ARG   A 1 920  ? 135.956 83.374  155.058 1.00 31.43  ?  920  ARG   C CA    1 
ATOM   5629 C C     . ARG   A 1 920  ? 135.824 84.658  154.255 1.00 32.96  ?  920  ARG   C C     1 
ATOM   5630 O O     . ARG   A 1 920  ? 136.680 85.538  154.349 1.00 34.65  ?  920  ARG   C O     1 
ATOM   5631 C CB    . ARG   A 1 920  ? 136.984 83.643  156.148 1.00 36.18  ?  920  ARG   C CB    1 
ATOM   5632 C CG    . ARG   A 1 920  ? 137.130 82.584  157.218 1.00 46.49  ?  920  ARG   C CG    1 
ATOM   5633 C CD    . ARG   A 1 920  ? 138.052 83.048  158.293 1.00 48.03  ?  920  ARG   C CD    1 
ATOM   5634 N NE    . ARG   A 1 920  ? 137.555 84.256  158.961 1.00 55.30  ?  920  ARG   C NE    1 
ATOM   5635 C CZ    . ARG   A 1 920  ? 138.297 85.080  159.722 1.00 66.77  ?  920  ARG   C CZ    1 
ATOM   5636 N NH1   . ARG   A 1 920  ? 139.574 84.836  159.927 1.00 66.38  1  920  ARG   C NH1   1 
ATOM   5637 N NH2   . ARG   A 1 920  ? 137.725 86.140  160.263 1.00 70.45  ?  920  ARG   C NH2   1 
ATOM   5638 N N     . GLY   A 1 921  ? 134.732 84.791  153.507 1.00 35.09  ?  921  GLY   C N     1 
ATOM   5639 C CA    . GLY   A 1 921  ? 134.526 85.997  152.712 1.00 34.51  ?  921  GLY   C CA    1 
ATOM   5640 C C     . GLY   A 1 921  ? 133.967 85.733  151.320 1.00 29.42  ?  921  GLY   C C     1 
ATOM   5641 O O     . GLY   A 1 921  ? 133.748 86.666  150.547 1.00 32.55  ?  921  GLY   C O     1 
ATOM   5642 N N     . ASN   A 1 922  ? 133.728 84.475  150.993 1.00 26.91  ?  922  ASN   C N     1 
ATOM   5643 C CA    . ASN   A 1 922  ? 133.149 84.163  149.699 1.00 29.67  ?  922  ASN   C CA    1 
ATOM   5644 C C     . ASN   A 1 922  ? 131.656 84.371  149.777 1.00 37.37  ?  922  ASN   C C     1 
ATOM   5645 O O     . ASN   A 1 922  ? 131.137 84.709  150.834 1.00 41.91  ?  922  ASN   C O     1 
ATOM   5646 C CB    . ASN   A 1 922  ? 133.491 82.753  149.300 1.00 36.72  ?  922  ASN   C CB    1 
ATOM   5647 C CG    . ASN   A 1 922  ? 134.931 82.624  149.018 1.00 38.61  ?  922  ASN   C CG    1 
ATOM   5648 O OD1   . ASN   A 1 922  ? 135.452 83.193  148.043 1.00 39.48  ?  922  ASN   C OD1   1 
ATOM   5649 N ND2   . ASN   A 1 922  ? 135.598 81.895  149.856 1.00 39.19  ?  922  ASN   C ND2   1 
ATOM   5650 N N     . THR   A 1 923  ? 130.955 84.159  148.676 1.00 39.03  ?  923  THR   C N     1 
ATOM   5651 C CA    . THR   A 1 923  ? 129.510 84.294  148.683 1.00 39.27  ?  923  THR   C CA    1 
ATOM   5652 C C     . THR   A 1 923  ? 128.909 82.961  148.304 1.00 38.90  ?  923  THR   C C     1 
ATOM   5653 O O     . THR   A 1 923  ? 128.256 82.822  147.269 1.00 42.93  ?  923  THR   C O     1 
ATOM   5654 C CB    . THR   A 1 923  ? 129.039 85.386  147.716 1.00 38.73  ?  923  THR   C CB    1 
ATOM   5655 O OG1   . THR   A 1 923  ? 129.522 85.096  146.407 1.00 44.83  ?  923  THR   C OG1   1 
ATOM   5656 C CG2   . THR   A 1 923  ? 129.573 86.738  148.160 1.00 40.92  ?  923  THR   C CG2   1 
ATOM   5657 N N     . LEU   A 1 924  ? 129.184 81.970  149.140 1.00 39.33  ?  924  LEU   C N     1 
ATOM   5658 C CA    . LEU   A 1 924  ? 128.819 80.594  148.869 1.00 40.88  ?  924  LEU   C CA    1 
ATOM   5659 C C     . LEU   A 1 924  ? 127.308 80.451  148.749 1.00 47.30  ?  924  LEU   C C     1 
ATOM   5660 O O     . LEU   A 1 924  ? 126.811 79.796  147.833 1.00 53.44  ?  924  LEU   C O     1 
ATOM   5661 C CB    . LEU   A 1 924  ? 129.365 79.701  149.997 1.00 45.17  ?  924  LEU   C CB    1 
ATOM   5662 C CG    . LEU   A 1 924  ? 129.111 78.199  149.884 1.00 51.83  ?  924  LEU   C CG    1 
ATOM   5663 C CD1   . LEU   A 1 924  ? 129.802 77.641  148.633 1.00 53.44  ?  924  LEU   C CD1   1 
ATOM   5664 C CD2   . LEU   A 1 924  ? 129.625 77.503  151.139 1.00 57.18  ?  924  LEU   C CD2   1 
ATOM   5665 N N     . GLY   A 1 925  ? 126.574 81.077  149.663 1.00 45.70  ?  925  GLY   C N     1 
ATOM   5666 C CA    . GLY   A 1 925  ? 125.118 81.036  149.622 1.00 49.91  ?  925  GLY   C CA    1 
ATOM   5667 C C     . GLY   A 1 925  ? 124.563 79.735  150.193 1.00 53.00  ?  925  GLY   C C     1 
ATOM   5668 O O     . GLY   A 1 925  ? 125.313 78.813  150.521 1.00 51.82  ?  925  GLY   C O     1 
ATOM   5669 N N     . ASP   A 1 926  ? 123.237 79.657  150.284 1.00 53.65  ?  926  ASP   C N     1 
ATOM   5670 C CA    . ASP   A 1 926  ? 122.572 78.496  150.867 1.00 54.61  ?  926  ASP   C CA    1 
ATOM   5671 C C     . ASP   A 1 926  ? 122.677 77.259  149.979 1.00 56.03  ?  926  ASP   C C     1 
ATOM   5672 O O     . ASP   A 1 926  ? 122.796 76.137  150.472 1.00 58.87  ?  926  ASP   C O     1 
ATOM   5673 C CB    . ASP   A 1 926  ? 121.101 78.810  151.136 1.00 60.68  ?  926  ASP   C CB    1 
ATOM   5674 C CG    . ASP   A 1 926  ? 120.886 79.789  152.288 1.00 67.43  ?  926  ASP   C CG    1 
ATOM   5675 O OD1   . ASP   A 1 926  ? 121.792 80.002  153.071 1.00 62.95  ?  926  ASP   C OD1   1 
ATOM   5676 O OD2   . ASP   A 1 926  ? 119.817 80.332  152.357 1.00 70.87  -1 926  ASP   C OD2   1 
ATOM   5677 N N     . LYS   A 1 927  ? 122.635 77.458  148.667 1.00 56.28  ?  927  LYS   C N     1 
ATOM   5678 C CA    . LYS   A 1 927  ? 122.760 76.339  147.740 1.00 57.97  ?  927  LYS   C CA    1 
ATOM   5679 C C     . LYS   A 1 927  ? 124.177 75.805  147.785 1.00 59.39  ?  927  LYS   C C     1 
ATOM   5680 O O     . LYS   A 1 927  ? 124.419 74.599  147.693 1.00 60.21  ?  927  LYS   C O     1 
ATOM   5681 C CB    . LYS   A 1 927  ? 122.411 76.769  146.319 1.00 63.03  ?  927  LYS   C CB    1 
ATOM   5682 C CG    . LYS   A 1 927  ? 120.939 77.063  146.098 1.00 73.31  ?  927  LYS   C CG    1 
ATOM   5683 C CD    . LYS   A 1 927  ? 120.667 77.491  144.660 1.00 78.20  ?  927  LYS   C CD    1 
ATOM   5684 C CE    . LYS   A 1 927  ? 119.189 77.778  144.446 1.00 82.80  ?  927  LYS   C CE    1 
ATOM   5685 N NZ    . LYS   A 1 927  ? 118.905 78.246  143.062 1.00 84.95  1  927  LYS   C NZ    1 
ATOM   5686 N N     . GLY   A 1 928  ? 125.115 76.723  147.927 1.00 58.75  ?  928  GLY   C N     1 
ATOM   5687 C CA    . GLY   A 1 928  ? 126.520 76.383  147.980 1.00 60.19  ?  928  GLY   C CA    1 
ATOM   5688 C C     . GLY   A 1 928  ? 126.825 75.527  149.197 1.00 61.55  ?  928  GLY   C C     1 
ATOM   5689 O O     . GLY   A 1 928  ? 127.475 74.490  149.079 1.00 63.24  ?  928  GLY   C O     1 
ATOM   5690 N N     . ILE   A 1 929  ? 126.359 75.951  150.370 1.00 57.53  ?  929  ILE   C N     1 
ATOM   5691 C CA    . ILE   A 1 929  ? 126.636 75.184  151.576 1.00 55.43  ?  929  ILE   C CA    1 
ATOM   5692 C C     . ILE   A 1 929  ? 125.978 73.817  151.508 1.00 58.64  ?  929  ILE   C C     1 
ATOM   5693 O O     . ILE   A 1 929  ? 126.524 72.843  152.023 1.00 58.74  ?  929  ILE   C O     1 
ATOM   5694 C CB    . ILE   A 1 929  ? 126.218 75.944  152.855 1.00 54.83  ?  929  ILE   C CB    1 
ATOM   5695 C CG1   . ILE   A 1 929  ? 126.750 75.249  154.116 1.00 59.60  ?  929  ILE   C CG1   1 
ATOM   5696 C CG2   . ILE   A 1 929  ? 124.740 76.067  152.958 1.00 60.07  ?  929  ILE   C CG2   1 
ATOM   5697 C CD1   . ILE   A 1 929  ? 128.242 75.218  154.233 1.00 62.21  ?  929  ILE   C CD1   1 
ATOM   5698 N N     . LYS   A 1 930  ? 124.827 73.728  150.847 1.00 61.30  ?  930  LYS   C N     1 
ATOM   5699 C CA    . LYS   A 1 930  ? 124.181 72.435  150.686 1.00 65.32  ?  930  LYS   C CA    1 
ATOM   5700 C C     . LYS   A 1 930  ? 125.095 71.486  149.929 1.00 64.92  ?  930  LYS   C C     1 
ATOM   5701 O O     . LYS   A 1 930  ? 125.311 70.347  150.350 1.00 68.38  ?  930  LYS   C O     1 
ATOM   5702 C CB    . LYS   A 1 930  ? 122.859 72.586  149.929 1.00 66.33  ?  930  LYS   C CB    1 
ATOM   5703 C CG    . LYS   A 1 930  ? 122.117 71.279  149.663 1.00 68.21  ?  930  LYS   C CG    1 
ATOM   5704 C CD    . LYS   A 1 930  ? 121.556 70.710  150.943 1.00 70.50  ?  930  LYS   C CD    1 
ATOM   5705 C CE    . LYS   A 1 930  ? 120.767 69.448  150.708 1.00 72.86  ?  930  LYS   C CE    1 
ATOM   5706 N NZ    . LYS   A 1 930  ? 120.141 68.951  151.972 1.00 77.00  1  930  LYS   C NZ    1 
ATOM   5707 N N     . LEU   A 1 931  ? 125.662 71.968  148.827 1.00 60.47  ?  931  LEU   C N     1 
ATOM   5708 C CA    . LEU   A 1 931  ? 126.574 71.154  148.036 1.00 65.31  ?  931  LEU   C CA    1 
ATOM   5709 C C     . LEU   A 1 931  ? 127.847 70.839  148.810 1.00 67.39  ?  931  LEU   C C     1 
ATOM   5710 O O     . LEU   A 1 931  ? 128.393 69.734  148.709 1.00 66.86  ?  931  LEU   C O     1 
ATOM   5711 C CB    . LEU   A 1 931  ? 126.934 71.875  146.732 1.00 63.62  ?  931  LEU   C CB    1 
ATOM   5712 C CG    . LEU   A 1 931  ? 125.810 72.032  145.696 1.00 66.67  ?  931  LEU   C CG    1 
ATOM   5713 C CD1   . LEU   A 1 931  ? 126.291 72.967  144.585 1.00 72.53  ?  931  LEU   C CD1   1 
ATOM   5714 C CD2   . LEU   A 1 931  ? 125.442 70.664  145.125 1.00 73.16  ?  931  LEU   C CD2   1 
ATOM   5715 N N     . LEU   A 1 932  ? 128.328 71.804  149.587 1.00 64.01  ?  932  LEU   C N     1 
ATOM   5716 C CA    . LEU   A 1 932  ? 129.555 71.592  150.333 1.00 63.99  ?  932  LEU   C CA    1 
ATOM   5717 C C     . LEU   A 1 932  ? 129.314 70.506  151.365 1.00 63.03  ?  932  LEU   C C     1 
ATOM   5718 O O     . LEU   A 1 932  ? 130.180 69.665  151.606 1.00 61.25  ?  932  LEU   C O     1 
ATOM   5719 C CB    . LEU   A 1 932  ? 130.001 72.879  151.046 1.00 61.22  ?  932  LEU   C CB    1 
ATOM   5720 C CG    . LEU   A 1 932  ? 131.452 72.904  151.599 1.00 57.47  ?  932  LEU   C CG    1 
ATOM   5721 C CD1   . LEU   A 1 932  ? 132.455 72.803  150.437 1.00 52.75  ?  932  LEU   C CD1   1 
ATOM   5722 C CD2   . LEU   A 1 932  ? 131.672 74.191  152.384 1.00 56.02  ?  932  LEU   C CD2   1 
ATOM   5723 N N     . CYS   A 1 933  ? 128.118 70.517  151.953 1.00 63.68  ?  933  CYS   C N     1 
ATOM   5724 C CA    . CYS   A 1 933  ? 127.752 69.523  152.945 1.00 66.09  ?  933  CYS   C CA    1 
ATOM   5725 C C     . CYS   A 1 933  ? 127.735 68.135  152.334 1.00 65.05  ?  933  CYS   C C     1 
ATOM   5726 O O     . CYS   A 1 933  ? 128.267 67.199  152.920 1.00 66.47  ?  933  CYS   C O     1 
ATOM   5727 C CB    . CYS   A 1 933  ? 126.385 69.825  153.554 1.00 69.14  ?  933  CYS   C CB    1 
ATOM   5728 S SG    . CYS   A 1 933  ? 126.363 71.277  154.633 1.00 77.53  ?  933  CYS   C SG    1 
ATOM   5729 N N     . GLU   A 1 934  ? 127.190 67.998  151.129 1.00 66.00  ?  934  GLU   C N     1 
ATOM   5730 C CA    . GLU   A 1 934  ? 127.156 66.679  150.507 1.00 69.36  ?  934  GLU   C CA    1 
ATOM   5731 C C     . GLU   A 1 934  ? 128.561 66.097  150.426 1.00 68.10  ?  934  GLU   C C     1 
ATOM   5732 O O     . GLU   A 1 934  ? 128.765 64.907  150.679 1.00 67.41  ?  934  GLU   C O     1 
ATOM   5733 C CB    . GLU   A 1 934  ? 126.544 66.748  149.107 1.00 71.64  ?  934  GLU   C CB    1 
ATOM   5734 C CG    . GLU   A 1 934  ? 125.043 67.007  149.080 1.00 78.13  ?  934  GLU   C CG    1 
ATOM   5735 C CD    . GLU   A 1 934  ? 124.496 67.133  147.681 1.00 85.69  ?  934  GLU   C CD    1 
ATOM   5736 O OE1   . GLU   A 1 934  ? 125.277 67.156  146.759 1.00 80.40  ?  934  GLU   C OE1   1 
ATOM   5737 O OE2   . GLU   A 1 934  ? 123.298 67.205  147.535 1.00 82.74  -1 934  GLU   C OE2   1 
ATOM   5738 N N     . GLY   A 1 935  ? 129.534 66.942  150.101 1.00 64.87  ?  935  GLY   C N     1 
ATOM   5739 C CA    . GLY   A 1 935  ? 130.933 66.531  150.068 1.00 67.14  ?  935  GLY   C CA    1 
ATOM   5740 C C     . GLY   A 1 935  ? 131.446 66.173  151.463 1.00 64.21  ?  935  GLY   C C     1 
ATOM   5741 O O     . GLY   A 1 935  ? 132.037 65.115  151.671 1.00 65.28  ?  935  GLY   C O     1 
ATOM   5742 N N     . LEU   A 1 936  ? 131.206 67.059  152.421 1.00 61.83  ?  936  LEU   C N     1 
ATOM   5743 C CA    . LEU   A 1 936  ? 131.698 66.887  153.782 1.00 58.74  ?  936  LEU   C CA    1 
ATOM   5744 C C     . LEU   A 1 936  ? 131.102 65.660  154.454 1.00 63.22  ?  936  LEU   C C     1 
ATOM   5745 O O     . LEU   A 1 936  ? 131.753 65.002  155.264 1.00 65.99  ?  936  LEU   C O     1 
ATOM   5746 C CB    . LEU   A 1 936  ? 131.353 68.127  154.602 1.00 56.59  ?  936  LEU   C CB    1 
ATOM   5747 C CG    . LEU   A 1 936  ? 132.055 69.413  154.192 1.00 56.40  ?  936  LEU   C CG    1 
ATOM   5748 C CD1   . LEU   A 1 936  ? 131.360 70.588  154.831 1.00 57.80  ?  936  LEU   C CD1   1 
ATOM   5749 C CD2   . LEU   A 1 936  ? 133.492 69.363  154.628 1.00 56.09  ?  936  LEU   C CD2   1 
ATOM   5750 N N     . LEU   A 1 937  ? 129.861 65.351  154.105 1.00 64.99  ?  937  LEU   C N     1 
ATOM   5751 C CA    . LEU   A 1 937  ? 129.134 64.221  154.665 1.00 66.89  ?  937  LEU   C CA    1 
ATOM   5752 C C     . LEU   A 1 937  ? 129.642 62.887  154.133 1.00 66.40  ?  937  LEU   C C     1 
ATOM   5753 O O     . LEU   A 1 937  ? 129.265 61.828  154.638 1.00 68.50  ?  937  LEU   C O     1 
ATOM   5754 C CB    . LEU   A 1 937  ? 127.640 64.358  154.337 1.00 67.50  ?  937  LEU   C CB    1 
ATOM   5755 C CG    . LEU   A 1 937  ? 126.887 65.523  155.022 1.00 71.51  ?  937  LEU   C CG    1 
ATOM   5756 C CD1   . LEU   A 1 937  ? 125.527 65.697  154.370 1.00 73.64  ?  937  LEU   C CD1   1 
ATOM   5757 C CD2   . LEU   A 1 937  ? 126.725 65.223  156.484 1.00 77.91  ?  937  LEU   C CD2   1 
ATOM   5758 N N     . HIS   A 1 938  ? 130.477 62.931  153.102 1.00 63.53  ?  938  HIS   C N     1 
ATOM   5759 C CA    . HIS   A 1 938  ? 131.018 61.721  152.514 1.00 66.87  ?  938  HIS   C CA    1 
ATOM   5760 C C     . HIS   A 1 938  ? 131.912 61.029  153.548 1.00 66.62  ?  938  HIS   C C     1 
ATOM   5761 O O     . HIS   A 1 938  ? 132.711 61.695  154.204 1.00 65.77  ?  938  HIS   C O     1 
ATOM   5762 C CB    . HIS   A 1 938  ? 131.823 62.074  151.254 1.00 67.10  ?  938  HIS   C CB    1 
ATOM   5763 C CG    . HIS   A 1 938  ? 132.201 60.905  150.422 1.00 70.10  ?  938  HIS   C CG    1 
ATOM   5764 N ND1   . HIS   A 1 938  ? 133.218 60.040  150.768 1.00 70.18  ?  938  HIS   C ND1   1 
ATOM   5765 C CD2   . HIS   A 1 938  ? 131.697 60.449  149.252 1.00 73.50  ?  938  HIS   C CD2   1 
ATOM   5766 C CE1   . HIS   A 1 938  ? 133.317 59.097  149.842 1.00 74.32  ?  938  HIS   C CE1   1 
ATOM   5767 N NE2   . HIS   A 1 938  ? 132.404 59.325  148.917 1.00 74.10  ?  938  HIS   C NE2   1 
ATOM   5768 N N     . PRO   A 1 939  ? 131.811 59.703  153.710 1.00 66.26  ?  939  PRO   C N     1 
ATOM   5769 C CA    . PRO   A 1 939  ? 132.533 58.912  154.693 1.00 67.95  ?  939  PRO   C CA    1 
ATOM   5770 C C     . PRO   A 1 939  ? 134.049 58.992  154.558 1.00 68.91  ?  939  PRO   C C     1 
ATOM   5771 O O     . PRO   A 1 939  ? 134.769 58.741  155.527 1.00 68.96  ?  939  PRO   C O     1 
ATOM   5772 C CB    . PRO   A 1 939  ? 132.016 57.488  154.423 1.00 71.13  ?  939  PRO   C CB    1 
ATOM   5773 C CG    . PRO   A 1 939  ? 131.439 57.527  153.027 1.00 73.42  ?  939  PRO   C CG    1 
ATOM   5774 C CD    . PRO   A 1 939  ? 130.887 58.919  152.876 1.00 69.56  ?  939  PRO   C CD    1 
ATOM   5775 N N     . ASP   A 1 940  ? 134.553 59.344  153.377 1.00 68.69  ?  940  ASP   C N     1 
ATOM   5776 C CA    . ASP   A 1 940  ? 135.994 59.419  153.190 1.00 69.87  ?  940  ASP   C CA    1 
ATOM   5777 C C     . ASP   A 1 940  ? 136.546 60.835  153.338 1.00 69.62  ?  940  ASP   C C     1 
ATOM   5778 O O     . ASP   A 1 940  ? 137.728 61.072  153.086 1.00 66.22  ?  940  ASP   C O     1 
ATOM   5779 C CB    . ASP   A 1 940  ? 136.394 58.848  151.828 1.00 72.27  ?  940  ASP   C CB    1 
ATOM   5780 C CG    . ASP   A 1 940  ? 136.156 57.340  151.719 1.00 77.91  ?  940  ASP   C CG    1 
ATOM   5781 O OD1   . ASP   A 1 940  ? 136.169 56.676  152.730 1.00 74.98  ?  940  ASP   C OD1   1 
ATOM   5782 O OD2   . ASP   A 1 940  ? 135.987 56.862  150.621 1.00 79.87  -1 940  ASP   C OD2   1 
ATOM   5783 N N     . CYS   A 1 941  ? 135.709 61.783  153.752 1.00 66.16  ?  941  CYS   C N     1 
ATOM   5784 C CA    . CYS   A 1 941  ? 136.190 63.145  153.954 1.00 62.71  ?  941  CYS   C CA    1 
ATOM   5785 C C     . CYS   A 1 941  ? 136.890 63.255  155.306 1.00 56.91  ?  941  CYS   C C     1 
ATOM   5786 O O     . CYS   A 1 941  ? 136.367 62.793  156.320 1.00 59.91  ?  941  CYS   C O     1 
ATOM   5787 C CB    . CYS   A 1 941  ? 135.050 64.160  153.883 1.00 64.93  ?  941  CYS   C CB    1 
ATOM   5788 S SG    . CYS   A 1 941  ? 135.601 65.879  154.031 1.00 62.34  ?  941  CYS   C SG    1 
ATOM   5789 N N     . LYS   A 1 942  ? 138.083 63.839  155.314 1.00 55.52  ?  942  LYS   C N     1 
ATOM   5790 C CA    . LYS   A 1 942  ? 138.878 63.963  156.534 1.00 53.00  ?  942  LYS   C CA    1 
ATOM   5791 C C     . LYS   A 1 942  ? 139.005 65.402  157.024 1.00 48.52  ?  942  LYS   C C     1 
ATOM   5792 O O     . LYS   A 1 942  ? 139.823 65.687  157.898 1.00 47.82  ?  942  LYS   C O     1 
ATOM   5793 C CB    . LYS   A 1 942  ? 140.275 63.379  156.319 1.00 56.35  ?  942  LYS   C CB    1 
ATOM   5794 C CG    . LYS   A 1 942  ? 140.310 61.887  155.997 1.00 60.28  ?  942  LYS   C CG    1 
ATOM   5795 C CD    . LYS   A 1 942  ? 139.766 61.055  157.151 1.00 59.78  ?  942  LYS   C CD    1 
ATOM   5796 C CE    . LYS   A 1 942  ? 140.207 59.595  157.058 1.00 66.84  ?  942  LYS   C CE    1 
ATOM   5797 N NZ    . LYS   A 1 942  ? 139.623 58.897  155.876 1.00 69.97  1  942  LYS   C NZ    1 
ATOM   5798 N N     . LEU   A 1 943  ? 138.223 66.313  156.460 1.00 46.22  ?  943  LEU   C N     1 
ATOM   5799 C CA    . LEU   A 1 943  ? 138.354 67.717  156.831 1.00 42.14  ?  943  LEU   C CA    1 
ATOM   5800 C C     . LEU   A 1 943  ? 138.151 67.885  158.329 1.00 45.42  ?  943  LEU   C C     1 
ATOM   5801 O O     . LEU   A 1 943  ? 137.183 67.370  158.889 1.00 50.98  ?  943  LEU   C O     1 
ATOM   5802 C CB    . LEU   A 1 943  ? 137.321 68.582  156.094 1.00 40.88  ?  943  LEU   C CB    1 
ATOM   5803 C CG    . LEU   A 1 943  ? 137.548 70.111  156.187 1.00 43.12  ?  943  LEU   C CG    1 
ATOM   5804 C CD1   . LEU   A 1 943  ? 138.745 70.490  155.324 1.00 45.57  ?  943  LEU   C CD1   1 
ATOM   5805 C CD2   . LEU   A 1 943  ? 136.310 70.855  155.741 1.00 44.83  ?  943  LEU   C CD2   1 
ATOM   5806 N N     . GLN   A 1 944  ? 139.061 68.608  158.979 1.00 45.07  ?  944  GLN   C N     1 
ATOM   5807 C CA    . GLN   A 1 944  ? 138.978 68.829  160.414 1.00 47.89  ?  944  GLN   C CA    1 
ATOM   5808 C C     . GLN   A 1 944  ? 138.425 70.207  160.728 1.00 47.12  ?  944  GLN   C C     1 
ATOM   5809 O O     . GLN   A 1 944  ? 137.656 70.381  161.678 1.00 53.03  ?  944  GLN   C O     1 
ATOM   5810 C CB    . GLN   A 1 944  ? 140.357 68.682  161.055 1.00 43.18  ?  944  GLN   C CB    1 
ATOM   5811 C CG    . GLN   A 1 944  ? 140.934 67.294  160.963 1.00 47.37  ?  944  GLN   C CG    1 
ATOM   5812 C CD    . GLN   A 1 944  ? 142.309 67.210  161.581 1.00 51.80  ?  944  GLN   C CD    1 
ATOM   5813 O OE1   . GLN   A 1 944  ? 142.827 68.202  162.102 1.00 48.88  ?  944  GLN   C OE1   1 
ATOM   5814 N NE2   . GLN   A 1 944  ? 142.915 66.032  161.523 1.00 51.32  ?  944  GLN   C NE2   1 
ATOM   5815 N N     . VAL   A 1 945  ? 138.835 71.194  159.942 1.00 39.50  ?  945  VAL   C N     1 
ATOM   5816 C CA    . VAL   A 1 945  ? 138.424 72.564  160.190 1.00 37.38  ?  945  VAL   C CA    1 
ATOM   5817 C C     . VAL   A 1 945  ? 137.714 73.195  159.011 1.00 37.87  ?  945  VAL   C C     1 
ATOM   5818 O O     . VAL   A 1 945  ? 138.274 73.316  157.919 1.00 43.29  ?  945  VAL   C O     1 
ATOM   5819 C CB    . VAL   A 1 945  ? 139.641 73.422  160.539 1.00 40.72  ?  945  VAL   C CB    1 
ATOM   5820 C CG1   . VAL   A 1 945  ? 139.207 74.860  160.755 1.00 42.81  ?  945  VAL   C CG1   1 
ATOM   5821 C CG2   . VAL   A 1 945  ? 140.310 72.857  161.779 1.00 49.43  ?  945  VAL   C CG2   1 
ATOM   5822 N N     . LEU   A 1 946  ? 136.498 73.649  159.256 1.00 38.88  ?  946  LEU   C N     1 
ATOM   5823 C CA    . LEU   A 1 946  ? 135.727 74.351  158.247 1.00 33.71  ?  946  LEU   C CA    1 
ATOM   5824 C C     . LEU   A 1 946  ? 135.387 75.759  158.710 1.00 36.05  ?  946  LEU   C C     1 
ATOM   5825 O O     . LEU   A 1 946  ? 134.662 75.935  159.694 1.00 49.87  ?  946  LEU   C O     1 
ATOM   5826 C CB    . LEU   A 1 946  ? 134.444 73.573  157.952 1.00 37.50  ?  946  LEU   C CB    1 
ATOM   5827 C CG    . LEU   A 1 946  ? 133.451 74.228  156.993 1.00 37.15  ?  946  LEU   C CG    1 
ATOM   5828 C CD1   . LEU   A 1 946  ? 134.085 74.381  155.615 1.00 37.94  ?  946  LEU   C CD1   1 
ATOM   5829 C CD2   . LEU   A 1 946  ? 132.211 73.360  156.926 1.00 47.72  ?  946  LEU   C CD2   1 
ATOM   5830 N N     . GLU   A 1 947  ? 135.893 76.762  158.006 1.00 31.18  ?  947  GLU   C N     1 
ATOM   5831 C CA    . GLU   A 1 947  ? 135.612 78.138  158.394 1.00 35.22  ?  947  GLU   C CA    1 
ATOM   5832 C C     . GLU   A 1 947  ? 134.770 78.853  157.354 1.00 35.24  ?  947  GLU   C C     1 
ATOM   5833 O O     . GLU   A 1 947  ? 135.169 79.011  156.198 1.00 37.33  ?  947  GLU   C O     1 
ATOM   5834 C CB    . GLU   A 1 947  ? 136.902 78.909  158.679 1.00 38.67  ?  947  GLU   C CB    1 
ATOM   5835 C CG    . GLU   A 1 947  ? 137.653 78.409  159.922 1.00 47.73  ?  947  GLU   C CG    1 
ATOM   5836 C CD    . GLU   A 1 947  ? 138.817 79.279  160.326 1.00 54.35  ?  947  GLU   C CD    1 
ATOM   5837 O OE1   . GLU   A 1 947  ? 139.111 80.208  159.621 1.00 46.42  ?  947  GLU   C OE1   1 
ATOM   5838 O OE2   . GLU   A 1 947  ? 139.408 79.014  161.349 1.00 55.68  -1 947  GLU   C OE2   1 
ATOM   5839 N N     . LEU   A 1 948  ? 133.584 79.271  157.776 1.00 37.83  ?  948  LEU   C N     1 
ATOM   5840 C CA    . LEU   A 1 948  ? 132.615 79.910  156.902 1.00 33.77  ?  948  LEU   C CA    1 
ATOM   5841 C C     . LEU   A 1 948  ? 132.200 81.267  157.440 1.00 37.49  ?  948  LEU   C C     1 
ATOM   5842 O O     . LEU   A 1 948  ? 131.127 81.410  158.030 1.00 42.40  ?  948  LEU   C O     1 
ATOM   5843 C CB    . LEU   A 1 948  ? 131.369 79.031  156.770 1.00 33.92  ?  948  LEU   C CB    1 
ATOM   5844 C CG    . LEU   A 1 948  ? 131.562 77.664  156.135 1.00 33.41  ?  948  LEU   C CG    1 
ATOM   5845 C CD1   . LEU   A 1 948  ? 130.343 76.824  156.411 1.00 40.15  ?  948  LEU   C CD1   1 
ATOM   5846 C CD2   . LEU   A 1 948  ? 131.763 77.827  154.647 1.00 34.46  ?  948  LEU   C CD2   1 
ATOM   5847 N N     . ASP   A 1 949  ? 133.034 82.268  157.224 1.00 39.85  ?  949  ASP   C N     1 
ATOM   5848 C CA    . ASP   A 1 949  ? 132.701 83.605  157.682 1.00 42.38  ?  949  ASP   C CA    1 
ATOM   5849 C C     . ASP   A 1 949  ? 131.690 84.147  156.708 1.00 37.88  ?  949  ASP   C C     1 
ATOM   5850 O O     . ASP   A 1 949  ? 131.280 83.423  155.810 1.00 35.66  ?  949  ASP   C O     1 
ATOM   5851 C CB    . ASP   A 1 949  ? 133.924 84.512  157.775 1.00 51.27  ?  949  ASP   C CB    1 
ATOM   5852 C CG    . ASP   A 1 949  ? 133.772 85.624  158.816 1.00 56.37  ?  949  ASP   C CG    1 
ATOM   5853 O OD1   . ASP   A 1 949  ? 132.667 86.119  158.992 1.00 54.76  ?  949  ASP   C OD1   1 
ATOM   5854 O OD2   . ASP   A 1 949  ? 134.764 85.961  159.426 1.00 56.11  -1 949  ASP   C OD2   1 
ATOM   5855 N N     . ASN   A 1 950  ? 131.234 85.365  156.906 1.00 37.81  ?  950  ASN   C N     1 
ATOM   5856 C CA    . ASN   A 1 950  ? 130.147 85.889  156.095 1.00 41.12  ?  950  ASN   C CA    1 
ATOM   5857 C C     . ASN   A 1 950  ? 130.142 85.285  154.701 1.00 37.57  ?  950  ASN   C C     1 
ATOM   5858 O O     . ASN   A 1 950  ? 130.829 85.772  153.805 1.00 41.01  ?  950  ASN   C O     1 
ATOM   5859 C CB    . ASN   A 1 950  ? 130.223 87.393  156.002 1.00 44.07  ?  950  ASN   C CB    1 
ATOM   5860 C CG    . ASN   A 1 950  ? 129.021 87.984  155.321 1.00 55.41  ?  950  ASN   C CG    1 
ATOM   5861 O OD1   . ASN   A 1 950  ? 128.225 87.269  154.683 1.00 53.98  ?  950  ASN   C OD1   1 
ATOM   5862 N ND2   . ASN   A 1 950  ? 128.871 89.282  155.443 1.00 52.49  ?  950  ASN   C ND2   1 
ATOM   5863 N N     . CYS   A 1 951  ? 129.327 84.246  154.525 1.00 38.55  ?  951  CYS   C N     1 
ATOM   5864 C CA    . CYS   A 1 951  ? 129.117 83.585  153.244 1.00 38.79  ?  951  CYS   C CA    1 
ATOM   5865 C C     . CYS   A 1 951  ? 127.689 83.794  152.777 1.00 43.83  ?  951  CYS   C C     1 
ATOM   5866 O O     . CYS   A 1 951  ? 127.172 83.029  151.960 1.00 49.93  ?  951  CYS   C O     1 
ATOM   5867 C CB    . CYS   A 1 951  ? 129.388 82.078  153.337 1.00 42.61  ?  951  CYS   C CB    1 
ATOM   5868 S SG    . CYS   A 1 951  ? 131.107 81.602  153.510 1.00 55.25  ?  951  CYS   C SG    1 
ATOM   5869 N N     . ASN   A 1 952  ? 127.038 84.809  153.335 1.00 42.81  ?  952  ASN   C N     1 
ATOM   5870 C CA    . ASN   A 1 952  ? 125.641 85.091  153.037 1.00 44.61  ?  952  ASN   C CA    1 
ATOM   5871 C C     . ASN   A 1 952  ? 124.752 83.872  153.261 1.00 47.16  ?  952  ASN   C C     1 
ATOM   5872 O O     . ASN   A 1 952  ? 123.839 83.615  152.476 1.00 50.83  ?  952  ASN   C O     1 
ATOM   5873 C CB    . ASN   A 1 952  ? 125.485 85.603  151.618 1.00 49.41  ?  952  ASN   C CB    1 
ATOM   5874 C CG    . ASN   A 1 952  ? 126.166 86.918  151.402 1.00 51.66  ?  952  ASN   C CG    1 
ATOM   5875 O OD1   . ASN   A 1 952  ? 126.229 87.761  152.303 1.00 49.92  ?  952  ASN   C OD1   1 
ATOM   5876 N ND2   . ASN   A 1 952  ? 126.673 87.118  150.215 1.00 58.41  ?  952  ASN   C ND2   1 
ATOM   5877 N N     . LEU   A 1 953  ? 125.007 83.130  154.334 1.00 44.96  ?  953  LEU   C N     1 
ATOM   5878 C CA    . LEU   A 1 953  ? 124.180 81.972  154.645 1.00 48.63  ?  953  LEU   C CA    1 
ATOM   5879 C C     . LEU   A 1 953  ? 123.065 82.394  155.575 1.00 58.45  ?  953  LEU   C C     1 
ATOM   5880 O O     . LEU   A 1 953  ? 123.270 83.234  156.453 1.00 60.88  ?  953  LEU   C O     1 
ATOM   5881 C CB    . LEU   A 1 953  ? 125.006 80.877  155.331 1.00 44.33  ?  953  LEU   C CB    1 
ATOM   5882 C CG    . LEU   A 1 953  ? 126.244 80.400  154.594 1.00 51.03  ?  953  LEU   C CG    1 
ATOM   5883 C CD1   . LEU   A 1 953  ? 126.966 79.346  155.439 1.00 52.04  ?  953  LEU   C CD1   1 
ATOM   5884 C CD2   . LEU   A 1 953  ? 125.857 79.846  153.250 1.00 58.63  ?  953  LEU   C CD2   1 
ATOM   5885 N N     . THR   A 1 954  ? 121.895 81.796  155.424 1.00 58.25  ?  954  THR   C N     1 
ATOM   5886 C CA    . THR   A 1 954  ? 120.816 82.128  156.339 1.00 61.16  ?  954  THR   C CA    1 
ATOM   5887 C C     . THR   A 1 954  ? 120.082 80.905  156.859 1.00 63.69  ?  954  THR   C C     1 
ATOM   5888 O O     . THR   A 1 954  ? 120.533 79.772  156.695 1.00 64.43  ?  954  THR   C O     1 
ATOM   5889 C CB    . THR   A 1 954  ? 119.829 83.130  155.712 1.00 62.73  ?  954  THR   C CB    1 
ATOM   5890 O OG1   . THR   A 1 954  ? 118.935 83.591  156.734 1.00 65.13  ?  954  THR   C OG1   1 
ATOM   5891 C CG2   . THR   A 1 954  ? 119.041 82.503  154.575 1.00 68.03  ?  954  THR   C CG2   1 
ATOM   5892 N N     . SER   A 1 955  ? 118.959 81.146  157.519 1.00 63.52  ?  955  SER   C N     1 
ATOM   5893 C CA    . SER   A 1 955  ? 118.226 80.111  158.231 1.00 68.82  ?  955  SER   C CA    1 
ATOM   5894 C C     . SER   A 1 955  ? 117.774 78.973  157.331 1.00 70.67  ?  955  SER   C C     1 
ATOM   5895 O O     . SER   A 1 955  ? 117.568 77.854  157.793 1.00 76.50  ?  955  SER   C O     1 
ATOM   5896 C CB    . SER   A 1 955  ? 117.018 80.724  158.906 1.00 68.58  ?  955  SER   C CB    1 
ATOM   5897 O OG    . SER   A 1 955  ? 116.093 81.173  157.958 1.00 70.97  ?  955  SER   C OG    1 
ATOM   5898 N N     . HIS   A 1 956  ? 117.666 79.229  156.041 1.00 68.69  ?  956  HIS   C N     1 
ATOM   5899 C CA    . HIS   A 1 956  ? 117.191 78.216  155.115 1.00 71.82  ?  956  HIS   C CA    1 
ATOM   5900 C C     . HIS   A 1 956  ? 118.169 77.052  154.980 1.00 76.06  ?  956  HIS   C C     1 
ATOM   5901 O O     . HIS   A 1 956  ? 117.800 75.981  154.500 1.00 79.37  ?  956  HIS   C O     1 
ATOM   5902 C CB    . HIS   A 1 956  ? 116.929 78.833  153.743 1.00 72.55  ?  956  HIS   C CB    1 
ATOM   5903 C CG    . HIS   A 1 956  ? 115.719 79.708  153.700 1.00 75.60  ?  956  HIS   C CG    1 
ATOM   5904 N ND1   . HIS   A 1 956  ? 114.441 79.216  153.850 1.00 76.47  ?  956  HIS   C ND1   1 
ATOM   5905 C CD2   . HIS   A 1 956  ? 115.589 81.043  153.522 1.00 76.14  ?  956  HIS   C CD2   1 
ATOM   5906 C CE1   . HIS   A 1 956  ? 113.577 80.211  153.765 1.00 78.14  ?  956  HIS   C CE1   1 
ATOM   5907 N NE2   . HIS   A 1 956  ? 114.247 81.328  153.565 1.00 76.88  ?  956  HIS   C NE2   1 
ATOM   5908 N N     . CYS   A 1 957  ? 119.416 77.258  155.396 1.00 70.99  ?  957  CYS   C N     1 
ATOM   5909 C CA    . CYS   A 1 957  ? 120.432 76.216  155.291 1.00 73.24  ?  957  CYS   C CA    1 
ATOM   5910 C C     . CYS   A 1 957  ? 120.777 75.606  156.641 1.00 73.04  ?  957  CYS   C C     1 
ATOM   5911 O O     . CYS   A 1 957  ? 121.642 74.732  156.735 1.00 77.42  ?  957  CYS   C O     1 
ATOM   5912 C CB    . CYS   A 1 957  ? 121.716 76.767  154.693 1.00 75.89  ?  957  CYS   C CB    1 
ATOM   5913 S SG    . CYS   A 1 957  ? 122.618 77.871  155.803 1.00 77.49  ?  957  CYS   C SG    1 
ATOM   5914 N N     . CYS   A 1 958  ? 120.128 76.082  157.694 1.00 70.83  ?  958  CYS   C N     1 
ATOM   5915 C CA    . CYS   A 1 958  ? 120.507 75.669  159.035 1.00 74.64  ?  958  CYS   C CA    1 
ATOM   5916 C C     . CYS   A 1 958  ? 120.269 74.185  159.263 1.00 78.64  ?  958  CYS   C C     1 
ATOM   5917 O O     . CYS   A 1 958  ? 120.913 73.569  160.113 1.00 80.42  ?  958  CYS   C O     1 
ATOM   5918 C CB    . CYS   A 1 958  ? 119.737 76.466  160.074 1.00 78.04  ?  958  CYS   C CB    1 
ATOM   5919 S SG    . CYS   A 1 958  ? 117.966 76.123  160.121 1.00 112.98 ?  958  CYS   C SG    1 
ATOM   5920 N N     . TRP   A 1 959  ? 119.356 73.608  158.493 1.00 82.40  ?  959  TRP   C N     1 
ATOM   5921 C CA    . TRP   A 1 959  ? 119.033 72.197  158.613 1.00 84.89  ?  959  TRP   C CA    1 
ATOM   5922 C C     . TRP   A 1 959  ? 120.171 71.319  158.115 1.00 81.09  ?  959  TRP   C C     1 
ATOM   5923 O O     . TRP   A 1 959  ? 120.360 70.202  158.603 1.00 81.30  ?  959  TRP   C O     1 
ATOM   5924 C CB    . TRP   A 1 959  ? 117.759 71.901  157.828 1.00 88.61  ?  959  TRP   C CB    1 
ATOM   5925 C CG    . TRP   A 1 959  ? 116.552 72.488  158.468 1.00 96.53  ?  959  TRP   C CG    1 
ATOM   5926 C CD1   . TRP   A 1 959  ? 115.921 73.643  158.121 1.00 97.61  ?  959  TRP   C CD1   1 
ATOM   5927 C CD2   . TRP   A 1 959  ? 115.823 71.953  159.589 1.00 100.90 ?  959  TRP   C CD2   1 
ATOM   5928 N NE1   . TRP   A 1 959  ? 114.853 73.862  158.951 1.00 99.40  ?  959  TRP   C NE1   1 
ATOM   5929 C CE2   . TRP   A 1 959  ? 114.771 72.834  159.848 1.00 105.75 ?  959  TRP   C CE2   1 
ATOM   5930 C CE3   . TRP   A 1 959  ? 115.961 70.804  160.368 1.00 108.23 ?  959  TRP   C CE3   1 
ATOM   5931 C CZ2   . TRP   A 1 959  ? 113.875 72.620  160.877 1.00 115.68 ?  959  TRP   C CZ2   1 
ATOM   5932 C CZ3   . TRP   A 1 959  ? 115.059 70.586  161.397 1.00 108.81 ?  959  TRP   C CZ3   1 
ATOM   5933 C CH2   . TRP   A 1 959  ? 114.038 71.470  161.642 1.00 113.96 ?  959  TRP   C CH2   1 
ATOM   5934 N N     . ASP   A 1 960  ? 120.946 71.825  157.159 1.00 76.20  ?  960  ASP   C N     1 
ATOM   5935 C CA    . ASP   A 1 960  ? 122.038 71.040  156.610 1.00 77.51  ?  960  ASP   C CA    1 
ATOM   5936 C C     . ASP   A 1 960  ? 123.262 71.175  157.485 1.00 76.51  ?  960  ASP   C C     1 
ATOM   5937 O O     . ASP   A 1 960  ? 124.012 70.216  157.665 1.00 77.35  ?  960  ASP   C O     1 
ATOM   5938 C CB    . ASP   A 1 960  ? 122.366 71.489  155.192 1.00 80.58  ?  960  ASP   C CB    1 
ATOM   5939 C CG    . ASP   A 1 960  ? 121.256 71.196  154.222 1.00 81.41  ?  960  ASP   C CG    1 
ATOM   5940 O OD1   . ASP   A 1 960  ? 120.972 70.038  153.988 1.00 81.63  ?  960  ASP   C OD1   1 
ATOM   5941 O OD2   . ASP   A 1 960  ? 120.695 72.127  153.706 1.00 77.94  -1 960  ASP   C OD2   1 
ATOM   5942 N N     . LEU   A 1 961  ? 123.448 72.359  158.053 1.00 77.22  ?  961  LEU   C N     1 
ATOM   5943 C CA    . LEU   A 1 961  ? 124.561 72.582  158.957 1.00 74.95  ?  961  LEU   C CA    1 
ATOM   5944 C C     . LEU   A 1 961  ? 124.351 71.776  160.230 1.00 76.50  ?  961  LEU   C C     1 
ATOM   5945 O O     . LEU   A 1 961  ? 125.296 71.211  160.780 1.00 75.23  ?  961  LEU   C O     1 
ATOM   5946 C CB    . LEU   A 1 961  ? 124.703 74.076  159.258 1.00 74.00  ?  961  LEU   C CB    1 
ATOM   5947 C CG    . LEU   A 1 961  ? 125.221 74.955  158.090 1.00 69.80  ?  961  LEU   C CG    1 
ATOM   5948 C CD1   . LEU   A 1 961  ? 124.986 76.416  158.421 1.00 67.84  ?  961  LEU   C CD1   1 
ATOM   5949 C CD2   . LEU   A 1 961  ? 126.720 74.698  157.881 1.00 69.26  ?  961  LEU   C CD2   1 
ATOM   5950 N N     . SER   A 1 962  ? 123.100 71.684  160.673 1.00 79.55  ?  962  SER   C N     1 
ATOM   5951 C CA    . SER   A 1 962  ? 122.777 70.871  161.835 1.00 83.96  ?  962  SER   C CA    1 
ATOM   5952 C C     . SER   A 1 962  ? 123.062 69.403  161.532 1.00 79.57  ?  962  SER   C C     1 
ATOM   5953 O O     . SER   A 1 962  ? 123.658 68.691  162.342 1.00 80.85  ?  962  SER   C O     1 
ATOM   5954 C CB    . SER   A 1 962  ? 121.326 71.058  162.223 1.00 91.59  ?  962  SER   C CB    1 
ATOM   5955 O OG    . SER   A 1 962  ? 121.017 70.303  163.358 1.00 94.65  ?  962  SER   C OG    1 
ATOM   5956 N N     . THR   A 1 963  ? 122.657 68.959  160.343 1.00 77.30  ?  963  THR   C N     1 
ATOM   5957 C CA    . THR   A 1 963  ? 122.910 67.589  159.924 1.00 79.31  ?  963  THR   C CA    1 
ATOM   5958 C C     . THR   A 1 963  ? 124.408 67.326  159.877 1.00 76.60  ?  963  THR   C C     1 
ATOM   5959 O O     . THR   A 1 963  ? 124.886 66.299  160.359 1.00 76.79  ?  963  THR   C O     1 
ATOM   5960 C CB    . THR   A 1 963  ? 122.294 67.311  158.538 1.00 83.81  ?  963  THR   C CB    1 
ATOM   5961 O OG1   . THR   A 1 963  ? 120.868 67.482  158.603 1.00 82.21  ?  963  THR   C OG1   1 
ATOM   5962 C CG2   . THR   A 1 963  ? 122.618 65.885  158.085 1.00 84.05  ?  963  THR   C CG2   1 
ATOM   5963 N N     . LEU   A 1 964  ? 125.154 68.272  159.321 1.00 76.03  ?  964  LEU   C N     1 
ATOM   5964 C CA    . LEU   A 1 964  ? 126.596 68.142  159.202 1.00 76.34  ?  964  LEU   C CA    1 
ATOM   5965 C C     . LEU   A 1 964  ? 127.231 67.877  160.560 1.00 76.40  ?  964  LEU   C C     1 
ATOM   5966 O O     . LEU   A 1 964  ? 128.083 66.998  160.695 1.00 75.43  ?  964  LEU   C O     1 
ATOM   5967 C CB    . LEU   A 1 964  ? 127.172 69.423  158.579 1.00 74.27  ?  964  LEU   C CB    1 
ATOM   5968 C CG    . LEU   A 1 964  ? 128.688 69.486  158.380 1.00 71.16  ?  964  LEU   C CG    1 
ATOM   5969 C CD1   . LEU   A 1 964  ? 129.135 68.387  157.425 1.00 71.85  ?  964  LEU   C CD1   1 
ATOM   5970 C CD2   . LEU   A 1 964  ? 129.052 70.861  157.830 1.00 67.52  ?  964  LEU   C CD2   1 
ATOM   5971 N N     . LEU   A 1 965  ? 126.778 68.594  161.581 1.00 75.74  ?  965  LEU   C N     1 
ATOM   5972 C CA    . LEU   A 1 965  ? 127.315 68.415  162.924 1.00 75.95  ?  965  LEU   C CA    1 
ATOM   5973 C C     . LEU   A 1 965  ? 127.097 66.996  163.454 1.00 79.25  ?  965  LEU   C C     1 
ATOM   5974 O O     . LEU   A 1 965  ? 127.934 66.475  164.193 1.00 81.20  ?  965  LEU   C O     1 
ATOM   5975 C CB    . LEU   A 1 965  ? 126.660 69.409  163.898 1.00 78.25  ?  965  LEU   C CB    1 
ATOM   5976 C CG    . LEU   A 1 965  ? 126.989 70.910  163.701 1.00 81.04  ?  965  LEU   C CG    1 
ATOM   5977 C CD1   . LEU   A 1 965  ? 126.077 71.741  164.608 1.00 83.85  ?  965  LEU   C CD1   1 
ATOM   5978 C CD2   . LEU   A 1 965  ? 128.448 71.168  164.033 1.00 74.21  ?  965  LEU   C CD2   1 
ATOM   5979 N N     . THR   A 1 966  ? 125.974 66.370  163.104 1.00 79.04  ?  966  THR   C N     1 
ATOM   5980 C CA    . THR   A 1 966  ? 125.693 65.035  163.630 1.00 80.34  ?  966  THR   C CA    1 
ATOM   5981 C C     . THR   A 1 966  ? 126.190 63.904  162.737 1.00 78.10  ?  966  THR   C C     1 
ATOM   5982 O O     . THR   A 1 966  ? 126.452 62.800  163.220 1.00 77.58  ?  966  THR   C O     1 
ATOM   5983 C CB    . THR   A 1 966  ? 124.183 64.835  163.847 1.00 86.11  ?  966  THR   C CB    1 
ATOM   5984 O OG1   . THR   A 1 966  ? 123.497 64.937  162.595 1.00 83.42  ?  966  THR   C OG1   1 
ATOM   5985 C CG2   . THR   A 1 966  ? 123.656 65.880  164.779 1.00 90.79  ?  966  THR   C CG2   1 
ATOM   5986 N N     . SER   A 1 967  ? 126.310 64.159  161.440 1.00 79.29  ?  967  SER   C N     1 
ATOM   5987 C CA    . SER   A 1 967  ? 126.707 63.104  160.516 1.00 82.95  ?  967  SER   C CA    1 
ATOM   5988 C C     . SER   A 1 967  ? 128.209 63.047  160.244 1.00 84.47  ?  967  SER   C C     1 
ATOM   5989 O O     . SER   A 1 967  ? 128.753 61.969  160.001 1.00 86.31  ?  967  SER   C O     1 
ATOM   5990 C CB    . SER   A 1 967  ? 125.963 63.258  159.210 1.00 82.99  ?  967  SER   C CB    1 
ATOM   5991 O OG    . SER   A 1 967  ? 124.598 62.982  159.365 1.00 80.88  ?  967  SER   C OG    1 
ATOM   5992 N N     . SER   A 1 968  ? 128.885 64.191  160.273 1.00 82.81  ?  968  SER   C N     1 
ATOM   5993 C CA    . SER   A 1 968  ? 130.309 64.213  159.963 1.00 82.21  ?  968  SER   C CA    1 
ATOM   5994 C C     . SER   A 1 968  ? 131.149 63.988  161.210 1.00 79.00  ?  968  SER   C C     1 
ATOM   5995 O O     . SER   A 1 968  ? 131.097 64.769  162.158 1.00 77.89  ?  968  SER   C O     1 
ATOM   5996 C CB    . SER   A 1 968  ? 130.696 65.523  159.316 1.00 76.84  ?  968  SER   C CB    1 
ATOM   5997 O OG    . SER   A 1 968  ? 132.084 65.595  159.126 1.00 70.71  ?  968  SER   C OG    1 
ATOM   5998 N N     . GLN   A 1 969  ? 131.918 62.904  161.210 1.00 77.96  ?  969  GLN   C N     1 
ATOM   5999 C CA    . GLN   A 1 969  ? 132.721 62.541  162.370 1.00 77.69  ?  969  GLN   C CA    1 
ATOM   6000 C C     . GLN   A 1 969  ? 134.165 63.014  162.260 1.00 73.15  ?  969  GLN   C C     1 
ATOM   6001 O O     . GLN   A 1 969  ? 134.972 62.773  163.158 1.00 73.83  ?  969  GLN   C O     1 
ATOM   6002 C CB    . GLN   A 1 969  ? 132.688 61.030  162.580 1.00 80.55  ?  969  GLN   C CB    1 
ATOM   6003 C CG    . GLN   A 1 969  ? 131.297 60.493  162.816 1.00 82.80  ?  969  GLN   C CG    1 
ATOM   6004 C CD    . GLN   A 1 969  ? 130.644 61.138  164.021 1.00 89.45  ?  969  GLN   C CD    1 
ATOM   6005 O OE1   . GLN   A 1 969  ? 131.218 61.161  165.112 1.00 87.86  ?  969  GLN   C OE1   1 
ATOM   6006 N NE2   . GLN   A 1 969  ? 129.445 61.672  163.830 1.00 84.20  ?  969  GLN   C NE2   1 
ATOM   6007 N N     . SER   A 1 970  ? 134.500 63.658  161.148 1.00 66.52  ?  970  SER   C N     1 
ATOM   6008 C CA    . SER   A 1 970  ? 135.872 64.095  160.916 1.00 64.73  ?  970  SER   C CA    1 
ATOM   6009 C C     . SER   A 1 970  ? 136.139 65.503  161.434 1.00 60.58  ?  970  SER   C C     1 
ATOM   6010 O O     . SER   A 1 970  ? 137.270 65.833  161.791 1.00 60.00  ?  970  SER   C O     1 
ATOM   6011 C CB    . SER   A 1 970  ? 136.192 64.032  159.438 1.00 66.62  ?  970  SER   C CB    1 
ATOM   6012 O OG    . SER   A 1 970  ? 136.159 62.708  158.973 1.00 68.52  ?  970  SER   C OG    1 
ATOM   6013 N N     . LEU   A 1 971  ? 135.103 66.331  161.480 1.00 58.69  ?  971  LEU   C N     1 
ATOM   6014 C CA    . LEU   A 1 971  ? 135.270 67.717  161.887 1.00 55.18  ?  971  LEU   C CA    1 
ATOM   6015 C C     . LEU   A 1 971  ? 135.594 67.836  163.362 1.00 58.89  ?  971  LEU   C C     1 
ATOM   6016 O O     . LEU   A 1 971  ? 135.065 67.100  164.195 1.00 66.88  ?  971  LEU   C O     1 
ATOM   6017 C CB    . LEU   A 1 971  ? 134.007 68.529  161.565 1.00 55.48  ?  971  LEU   C CB    1 
ATOM   6018 C CG    . LEU   A 1 971  ? 133.714 68.766  160.066 1.00 57.97  ?  971  LEU   C CG    1 
ATOM   6019 C CD1   . LEU   A 1 971  ? 132.313 69.355  159.913 1.00 64.18  ?  971  LEU   C CD1   1 
ATOM   6020 C CD2   . LEU   A 1 971  ? 134.763 69.731  159.482 1.00 54.57  ?  971  LEU   C CD2   1 
ATOM   6021 N N     . ARG   A 1 972  ? 136.467 68.778  163.679 1.00 57.50  ?  972  ARG   C N     1 
ATOM   6022 C CA    . ARG   A 1 972  ? 136.823 69.066  165.054 1.00 60.37  ?  972  ARG   C CA    1 
ATOM   6023 C C     . ARG   A 1 972  ? 136.464 70.506  165.365 1.00 61.63  ?  972  ARG   C C     1 
ATOM   6024 O O     . ARG   A 1 972  ? 136.173 70.852  166.514 1.00 69.01  ?  972  ARG   C O     1 
ATOM   6025 C CB    . ARG   A 1 972  ? 138.304 68.811  165.285 1.00 60.65  ?  972  ARG   C CB    1 
ATOM   6026 C CG    . ARG   A 1 972  ? 138.725 67.359  165.053 1.00 62.25  ?  972  ARG   C CG    1 
ATOM   6027 C CD    . ARG   A 1 972  ? 138.170 66.433  166.081 1.00 68.15  ?  972  ARG   C CD    1 
ATOM   6028 N NE    . ARG   A 1 972  ? 138.499 65.053  165.789 1.00 69.35  ?  972  ARG   C NE    1 
ATOM   6029 C CZ    . ARG   A 1 972  ? 137.729 64.211  165.061 1.00 70.07  ?  972  ARG   C CZ    1 
ATOM   6030 N NH1   . ARG   A 1 972  ? 136.579 64.606  164.556 1.00 68.06  1  972  ARG   C NH1   1 
ATOM   6031 N NH2   . ARG   A 1 972  ? 138.139 62.972  164.855 1.00 74.63  ?  972  ARG   C NH2   1 
ATOM   6032 N N     . LYS   A 1 973  ? 136.473 71.336  164.320 1.00 54.18  ?  973  LYS   C N     1 
ATOM   6033 C CA    . LYS   A 1 973  ? 136.095 72.735  164.435 1.00 56.00  ?  973  LYS   C CA    1 
ATOM   6034 C C     . LYS   A 1 973  ? 135.203 73.134  163.268 1.00 52.92  ?  973  LYS   C C     1 
ATOM   6035 O O     . LYS   A 1 973  ? 135.466 72.770  162.120 1.00 56.45  ?  973  LYS   C O     1 
ATOM   6036 C CB    . LYS   A 1 973  ? 137.324 73.649  164.460 1.00 55.73  ?  973  LYS   C CB    1 
ATOM   6037 C CG    . LYS   A 1 973  ? 136.993 75.128  164.723 1.00 59.61  ?  973  LYS   C CG    1 
ATOM   6038 C CD    . LYS   A 1 973  ? 138.219 75.942  165.162 1.00 63.45  ?  973  LYS   C CD    1 
ATOM   6039 C CE    . LYS   A 1 973  ? 139.144 76.252  163.996 1.00 60.72  ?  973  LYS   C CE    1 
ATOM   6040 N NZ    . LYS   A 1 973  ? 140.210 77.227  164.367 1.00 59.98  1  973  LYS   C NZ    1 
ATOM   6041 N N     . LEU   A 1 974  ? 134.168 73.902  163.563 1.00 49.66  ?  974  LEU   C N     1 
ATOM   6042 C CA    . LEU   A 1 974  ? 133.314 74.492  162.546 1.00 44.87  ?  974  LEU   C CA    1 
ATOM   6043 C C     . LEU   A 1 974  ? 132.966 75.877  163.010 1.00 45.18  ?  974  LEU   C C     1 
ATOM   6044 O O     . LEU   A 1 974  ? 132.460 76.048  164.115 1.00 57.51  ?  974  LEU   C O     1 
ATOM   6045 C CB    . LEU   A 1 974  ? 132.035 73.667  162.329 1.00 49.58  ?  974  LEU   C CB    1 
ATOM   6046 C CG    . LEU   A 1 974  ? 131.100 74.123  161.171 1.00 50.19  ?  974  LEU   C CG    1 
ATOM   6047 C CD1   . LEU   A 1 974  ? 130.415 72.905  160.586 1.00 54.33  ?  974  LEU   C CD1   1 
ATOM   6048 C CD2   . LEU   A 1 974  ? 130.040 75.107  161.699 1.00 45.22  ?  974  LEU   C CD2   1 
ATOM   6049 N N     . SER   A 1 975  ? 133.234 76.868  162.185 1.00 39.87  ?  975  SER   C N     1 
ATOM   6050 C CA    . SER   A 1 975  ? 132.982 78.226  162.619 1.00 42.79  ?  975  SER   C CA    1 
ATOM   6051 C C     . SER   A 1 975  ? 132.208 79.043  161.613 1.00 43.65  ?  975  SER   C C     1 
ATOM   6052 O O     . SER   A 1 975  ? 132.694 79.343  160.522 1.00 46.69  ?  975  SER   C O     1 
ATOM   6053 C CB    . SER   A 1 975  ? 134.294 78.914  162.927 1.00 50.04  ?  975  SER   C CB    1 
ATOM   6054 O OG    . SER   A 1 975  ? 134.098 80.270  163.224 1.00 53.81  ?  975  SER   C OG    1 
ATOM   6055 N N     . LEU   A 1 976  ? 131.003 79.430  162.001 1.00 46.39  ?  976  LEU   C N     1 
ATOM   6056 C CA    . LEU   A 1 976  ? 130.193 80.305  161.177 1.00 41.30  ?  976  LEU   C CA    1 
ATOM   6057 C C     . LEU   A 1 976  ? 130.457 81.726  161.634 1.00 45.05  ?  976  LEU   C C     1 
ATOM   6058 O O     . LEU   A 1 976  ? 130.596 81.974  162.835 1.00 51.28  ?  976  LEU   C O     1 
ATOM   6059 C CB    . LEU   A 1 976  ? 128.713 79.961  161.330 1.00 41.64  ?  976  LEU   C CB    1 
ATOM   6060 C CG    . LEU   A 1 976  ? 128.348 78.490  161.079 1.00 43.85  ?  976  LEU   C CG    1 
ATOM   6061 C CD1   . LEU   A 1 976  ? 126.892 78.291  161.371 1.00 55.52  ?  976  LEU   C CD1   1 
ATOM   6062 C CD2   . LEU   A 1 976  ? 128.668 78.112  159.645 1.00 46.70  ?  976  LEU   C CD2   1 
ATOM   6063 N N     . GLY   A 1 977  ? 130.547 82.651  160.694 1.00 45.50  ?  977  GLY   C N     1 
ATOM   6064 C CA    . GLY   A 1 977  ? 130.866 84.030  161.043 1.00 49.97  ?  977  GLY   C CA    1 
ATOM   6065 C C     . GLY   A 1 977  ? 129.691 84.978  160.918 1.00 48.40  ?  977  GLY   C C     1 
ATOM   6066 O O     . GLY   A 1 977  ? 128.578 84.683  161.354 1.00 49.21  ?  977  GLY   C O     1 
ATOM   6067 N N     . ASN   A 1 978  ? 129.960 86.145  160.346 1.00 48.25  ?  978  ASN   C N     1 
ATOM   6068 C CA    . ASN   A 1 978  ? 128.987 87.225  160.313 1.00 46.52  ?  978  ASN   C CA    1 
ATOM   6069 C C     . ASN   A 1 978  ? 127.901 87.000  159.270 1.00 45.86  ?  978  ASN   C C     1 
ATOM   6070 O O     . ASN   A 1 978  ? 127.860 87.668  158.238 1.00 49.54  ?  978  ASN   C O     1 
ATOM   6071 C CB    . ASN   A 1 978  ? 129.690 88.549  160.073 1.00 50.55  ?  978  ASN   C CB    1 
ATOM   6072 C CG    . ASN   A 1 978  ? 128.787 89.732  160.249 1.00 63.35  ?  978  ASN   C CG    1 
ATOM   6073 O OD1   . ASN   A 1 978  ? 127.807 89.667  160.996 1.00 65.23  ?  978  ASN   C OD1   1 
ATOM   6074 N ND2   . ASN   A 1 978  ? 129.095 90.812  159.573 1.00 62.55  ?  978  ASN   C ND2   1 
ATOM   6075 N N     . ASN   A 1 979  ? 127.010 86.065  159.562 1.00 42.12  ?  979  ASN   C N     1 
ATOM   6076 C CA    . ASN   A 1 979  ? 125.889 85.748  158.691 1.00 47.73  ?  979  ASN   C CA    1 
ATOM   6077 C C     . ASN   A 1 979  ? 124.658 85.458  159.538 1.00 54.35  ?  979  ASN   C C     1 
ATOM   6078 O O     . ASN   A 1 979  ? 124.769 84.955  160.653 1.00 54.94  ?  979  ASN   C O     1 
ATOM   6079 C CB    . ASN   A 1 979  ? 126.227 84.580  157.791 1.00 49.14  ?  979  ASN   C CB    1 
ATOM   6080 C CG    . ASN   A 1 979  ? 126.413 83.316  158.555 1.00 52.94  ?  979  ASN   C CG    1 
ATOM   6081 O OD1   . ASN   A 1 979  ? 127.455 83.072  159.173 1.00 50.89  ?  979  ASN   C OD1   1 
ATOM   6082 N ND2   . ASN   A 1 979  ? 125.407 82.491  158.523 1.00 59.43  ?  979  ASN   C ND2   1 
ATOM   6083 N N     . ASP   A 1 980  ? 123.478 85.773  159.016 1.00 58.12  ?  980  ASP   C N     1 
ATOM   6084 C CA    . ASP   A 1 980  ? 122.254 85.610  159.796 1.00 57.96  ?  980  ASP   C CA    1 
ATOM   6085 C C     . ASP   A 1 980  ? 121.690 84.196  159.753 1.00 57.90  ?  980  ASP   C C     1 
ATOM   6086 O O     . ASP   A 1 980  ? 120.668 83.944  159.114 1.00 60.92  ?  980  ASP   C O     1 
ATOM   6087 C CB    . ASP   A 1 980  ? 121.180 86.593  159.330 1.00 58.14  ?  980  ASP   C CB    1 
ATOM   6088 C CG    . ASP   A 1 980  ? 119.979 86.636  160.271 1.00 62.61  ?  980  ASP   C CG    1 
ATOM   6089 O OD1   . ASP   A 1 980  ? 120.108 86.184  161.388 1.00 59.26  ?  980  ASP   C OD1   1 
ATOM   6090 O OD2   . ASP   A 1 980  ? 118.950 87.132  159.871 1.00 66.44  -1 980  ASP   C OD2   1 
ATOM   6091 N N     . LEU   A 1 981  ? 122.344 83.290  160.473 1.00 55.43  ?  981  LEU   C N     1 
ATOM   6092 C CA    . LEU   A 1 981  ? 121.901 81.901  160.587 1.00 59.04  ?  981  LEU   C CA    1 
ATOM   6093 C C     . LEU   A 1 981  ? 120.513 81.815  161.206 1.00 67.31  ?  981  LEU   C C     1 
ATOM   6094 O O     . LEU   A 1 981  ? 119.736 80.911  160.896 1.00 71.79  ?  981  LEU   C O     1 
ATOM   6095 C CB    . LEU   A 1 981  ? 122.868 81.093  161.457 1.00 57.91  ?  981  LEU   C CB    1 
ATOM   6096 C CG    . LEU   A 1 981  ? 122.527 79.594  161.657 1.00 65.76  ?  981  LEU   C CG    1 
ATOM   6097 C CD1   . LEU   A 1 981  ? 122.567 78.854  160.318 1.00 71.75  ?  981  LEU   C CD1   1 
ATOM   6098 C CD2   . LEU   A 1 981  ? 123.515 78.993  162.641 1.00 68.60  ?  981  LEU   C CD2   1 
ATOM   6099 N N     . GLY   A 1 982  ? 120.223 82.721  162.132 1.00 65.04  ?  982  GLY   C N     1 
ATOM   6100 C CA    . GLY   A 1 982  ? 118.929 82.742  162.796 1.00 71.79  ?  982  GLY   C CA    1 
ATOM   6101 C C     . GLY   A 1 982  ? 118.943 81.987  164.118 1.00 73.91  ?  982  GLY   C C     1 
ATOM   6102 O O     . GLY   A 1 982  ? 119.905 81.287  164.447 1.00 73.18  ?  982  GLY   C O     1 
ATOM   6103 N N     . ASP   A 1 983  ? 117.850 82.117  164.861 1.00 75.82  ?  983  ASP   C N     1 
ATOM   6104 C CA    . ASP   A 1 983  ? 117.735 81.517  166.179 1.00 77.84  ?  983  ASP   C CA    1 
ATOM   6105 C C     . ASP   A 1 983  ? 117.407 80.040  166.074 1.00 80.15  ?  983  ASP   C C     1 
ATOM   6106 O O     . ASP   A 1 983  ? 117.792 79.252  166.934 1.00 83.33  ?  983  ASP   C O     1 
ATOM   6107 C CB    . ASP   A 1 983  ? 116.646 82.226  166.984 1.00 82.31  ?  983  ASP   C CB    1 
ATOM   6108 C CG    . ASP   A 1 983  ? 116.989 83.677  167.300 1.00 88.59  ?  983  ASP   C CG    1 
ATOM   6109 O OD1   . ASP   A 1 983  ? 117.718 83.920  168.241 1.00 89.07  ?  983  ASP   C OD1   1 
ATOM   6110 O OD2   . ASP   A 1 983  ? 116.525 84.532  166.583 1.00 84.14  -1 983  ASP   C OD2   1 
ATOM   6111 N N     . LEU   A 1 984  ? 116.692 79.655  165.026 1.00 78.43  ?  984  LEU   C N     1 
ATOM   6112 C CA    . LEU   A 1 984  ? 116.337 78.253  164.875 1.00 84.90  ?  984  LEU   C CA    1 
ATOM   6113 C C     . LEU   A 1 984  ? 117.591 77.417  164.708 1.00 84.15  ?  984  LEU   C C     1 
ATOM   6114 O O     . LEU   A 1 984  ? 117.748 76.379  165.350 1.00 92.60  ?  984  LEU   C O     1 
ATOM   6115 C CB    . LEU   A 1 984  ? 115.422 78.047  163.662 1.00 93.11  ?  984  LEU   C CB    1 
ATOM   6116 C CG    . LEU   A 1 984  ? 115.052 76.576  163.337 1.00 98.83  ?  984  LEU   C CG    1 
ATOM   6117 C CD1   . LEU   A 1 984  ? 114.278 75.959  164.498 1.00 97.64  ?  984  LEU   C CD1   1 
ATOM   6118 C CD2   . LEU   A 1 984  ? 114.241 76.535  162.053 1.00 101.37 ?  984  LEU   C CD2   1 
ATOM   6119 N N     . GLY   A 1 985  ? 118.493 77.882  163.852 1.00 84.26  ?  985  GLY   C N     1 
ATOM   6120 C CA    . GLY   A 1 985  ? 119.726 77.164  163.584 1.00 84.54  ?  985  GLY   C CA    1 
ATOM   6121 C C     . GLY   A 1 985  ? 120.545 76.984  164.846 1.00 87.90  ?  985  GLY   C C     1 
ATOM   6122 O O     . GLY   A 1 985  ? 120.972 75.873  165.162 1.00 86.39  ?  985  GLY   C O     1 
ATOM   6123 N N     . VAL   A 1 986  ? 120.748 78.069  165.580 1.00 81.23  ?  986  VAL   C N     1 
ATOM   6124 C CA    . VAL   A 1 986  ? 121.544 78.000  166.793 1.00 80.79  ?  986  VAL   C CA    1 
ATOM   6125 C C     . VAL   A 1 986  ? 120.908 77.111  167.853 1.00 85.71  ?  986  VAL   C C     1 
ATOM   6126 O O     . VAL   A 1 986  ? 121.611 76.357  168.531 1.00 85.67  ?  986  VAL   C O     1 
ATOM   6127 C CB    . VAL   A 1 986  ? 121.786 79.404  167.353 1.00 82.77  ?  986  VAL   C CB    1 
ATOM   6128 C CG1   . VAL   A 1 986  ? 122.436 79.318  168.718 1.00 90.08  ?  986  VAL   C CG1   1 
ATOM   6129 C CG2   . VAL   A 1 986  ? 122.677 80.149  166.398 1.00 79.30  ?  986  VAL   C CG2   1 
ATOM   6130 N N     . MET   A 1 987  ? 119.592 77.208  168.023 1.00 86.46  ?  987  MET   C N     1 
ATOM   6131 C CA    . MET   A 1 987  ? 118.933 76.365  169.009 1.00 90.36  ?  987  MET   C CA    1 
ATOM   6132 C C     . MET   A 1 987  ? 119.072 74.897  168.641 1.00 93.03  ?  987  MET   C C     1 
ATOM   6133 O O     . MET   A 1 987  ? 119.315 74.055  169.510 1.00 96.43  ?  987  MET   C O     1 
ATOM   6134 C CB    . MET   A 1 987  ? 117.461 76.740  169.148 1.00 90.29  ?  987  MET   C CB    1 
ATOM   6135 C CG    . MET   A 1 987  ? 117.211 78.076  169.842 1.00 93.33  ?  987  MET   C CG    1 
ATOM   6136 S SD    . MET   A 1 987  ? 117.879 78.144  171.517 1.00 101.44 ?  987  MET   C SD    1 
ATOM   6137 C CE    . MET   A 1 987  ? 116.855 76.950  172.374 1.00 107.08 ?  987  MET   C CE    1 
ATOM   6138 N N     . MET   A 1 988  ? 118.953 74.584  167.350 1.00 91.58  ?  988  MET   C N     1 
ATOM   6139 C CA    . MET   A 1 988  ? 119.144 73.208  166.929 1.00 92.93  ?  988  MET   C CA    1 
ATOM   6140 C C     . MET   A 1 988  ? 120.562 72.770  167.225 1.00 96.17  ?  988  MET   C C     1 
ATOM   6141 O O     . MET   A 1 988  ? 120.769 71.693  167.780 1.00 97.48  ?  988  MET   C O     1 
ATOM   6142 C CB    . MET   A 1 988  ? 118.836 73.020  165.447 1.00 91.32  ?  988  MET   C CB    1 
ATOM   6143 C CG    . MET   A 1 988  ? 117.361 73.102  165.094 1.00 95.73  ?  988  MET   C CG    1 
ATOM   6144 S SD    . MET   A 1 988  ? 117.005 72.545  163.416 1.00 106.36 ?  988  MET   C SD    1 
ATOM   6145 C CE    . MET   A 1 988  ? 117.902 73.707  162.405 1.00 92.48  ?  988  MET   C CE    1 
ATOM   6146 N N     . PHE   A 1 989  ? 121.536 73.633  166.919 1.00 93.66  ?  989  PHE   C N     1 
ATOM   6147 C CA    . PHE   A 1 989  ? 122.929 73.295  167.178 1.00 97.26  ?  989  PHE   C CA    1 
ATOM   6148 C C     . PHE   A 1 989  ? 123.103 72.907  168.632 1.00 91.30  ?  989  PHE   C C     1 
ATOM   6149 O O     . PHE   A 1 989  ? 123.701 71.881  168.946 1.00 96.01  ?  989  PHE   C O     1 
ATOM   6150 C CB    . PHE   A 1 989  ? 123.865 74.467  166.887 1.00 86.58  ?  989  PHE   C CB    1 
ATOM   6151 C CG    . PHE   A 1 989  ? 124.114 74.775  165.434 1.00 84.97  ?  989  PHE   C CG    1 
ATOM   6152 C CD1   . PHE   A 1 989  ? 123.392 74.172  164.400 1.00 85.34  ?  989  PHE   C CD1   1 
ATOM   6153 C CD2   . PHE   A 1 989  ? 125.094 75.689  165.102 1.00 80.36  ?  989  PHE   C CD2   1 
ATOM   6154 C CE1   . PHE   A 1 989  ? 123.659 74.495  163.085 1.00 82.36  ?  989  PHE   C CE1   1 
ATOM   6155 C CE2   . PHE   A 1 989  ? 125.355 76.002  163.796 1.00 78.44  ?  989  PHE   C CE2   1 
ATOM   6156 C CZ    . PHE   A 1 989  ? 124.637 75.411  162.786 1.00 79.26  ?  989  PHE   C CZ    1 
ATOM   6157 N N     . CYS   A 1 990  ? 122.548 73.709  169.530 1.00 96.39  ?  990  CYS   C N     1 
ATOM   6158 C CA    . CYS   A 1 990  ? 122.713 73.425  170.944 1.00 98.33  ?  990  CYS   C CA    1 
ATOM   6159 C C     . CYS   A 1 990  ? 122.262 72.011  171.283 1.00 101.40 ?  990  CYS   C C     1 
ATOM   6160 O O     . CYS   A 1 990  ? 122.958 71.292  171.998 1.00 103.41 ?  990  CYS   C O     1 
ATOM   6161 C CB    . CYS   A 1 990  ? 121.923 74.420  171.796 1.00 111.51 ?  990  CYS   C CB    1 
ATOM   6162 S SG    . CYS   A 1 990  ? 122.552 76.122  171.741 1.00 119.10 ?  990  CYS   C SG    1 
ATOM   6163 N N     . GLU   A 1 991  ? 121.107 71.607  170.768 1.00 104.87 ?  991  GLU   C N     1 
ATOM   6164 C CA    . GLU   A 1 991  ? 120.580 70.286  171.084 1.00 100.31 ?  991  GLU   C CA    1 
ATOM   6165 C C     . GLU   A 1 991  ? 121.350 69.151  170.407 1.00 111.42 ?  991  GLU   C C     1 
ATOM   6166 O O     . GLU   A 1 991  ? 121.633 68.127  171.026 1.00 103.91 ?  991  GLU   C O     1 
ATOM   6167 C CB    . GLU   A 1 991  ? 119.103 70.206  170.695 1.00 104.69 ?  991  GLU   C CB    1 
ATOM   6168 C CG    . GLU   A 1 991  ? 118.416 68.885  171.053 1.00 112.20 ?  991  GLU   C CG    1 
ATOM   6169 C CD    . GLU   A 1 991  ? 118.352 68.629  172.541 1.00 115.31 ?  991  GLU   C CD    1 
ATOM   6170 O OE1   . GLU   A 1 991  ? 118.529 69.556  173.300 1.00 111.42 ?  991  GLU   C OE1   1 
ATOM   6171 O OE2   . GLU   A 1 991  ? 118.124 67.504  172.917 1.00 109.25 -1 991  GLU   C OE2   1 
ATOM   6172 N N     . VAL   A 1 992  ? 121.707 69.321  169.140 1.00 101.17 ?  992  VAL   C N     1 
ATOM   6173 C CA    . VAL   A 1 992  ? 122.372 68.231  168.431 1.00 103.04 ?  992  VAL   C CA    1 
ATOM   6174 C C     . VAL   A 1 992  ? 123.805 68.035  168.909 1.00 103.60 ?  992  VAL   C C     1 
ATOM   6175 O O     . VAL   A 1 992  ? 124.327 66.922  168.882 1.00 107.84 ?  992  VAL   C O     1 
ATOM   6176 C CB    . VAL   A 1 992  ? 122.347 68.446  166.906 1.00 104.51 ?  992  VAL   C CB    1 
ATOM   6177 C CG1   . VAL   A 1 992  ? 120.909 68.544  166.421 1.00 102.46 ?  992  VAL   C CG1   1 
ATOM   6178 C CG2   . VAL   A 1 992  ? 123.117 69.684  166.531 1.00 97.85  ?  992  VAL   C CG2   1 
ATOM   6179 N N     . LEU   A 1 993  ? 124.427 69.105  169.390 1.00 104.65 ?  993  LEU   C N     1 
ATOM   6180 C CA    . LEU   A 1 993  ? 125.789 69.038  169.901 1.00 104.89 ?  993  LEU   C CA    1 
ATOM   6181 C C     . LEU   A 1 993  ? 125.871 68.238  171.197 1.00 108.23 ?  993  LEU   C C     1 
ATOM   6182 O O     . LEU   A 1 993  ? 126.961 67.892  171.652 1.00 107.94 ?  993  LEU   C O     1 
ATOM   6183 C CB    . LEU   A 1 993  ? 126.336 70.452  170.130 1.00 106.85 ?  993  LEU   C CB    1 
ATOM   6184 C CG    . LEU   A 1 993  ? 126.614 71.294  168.860 1.00 104.21 ?  993  LEU   C CG    1 
ATOM   6185 C CD1   . LEU   A 1 993  ? 126.816 72.735  169.262 1.00 101.25 ?  993  LEU   C CD1   1 
ATOM   6186 C CD2   . LEU   A 1 993  ? 127.861 70.772  168.149 1.00 101.06 ?  993  LEU   C CD2   1 
ATOM   6187 N N     . LYS   A 1 994  ? 124.719 67.939  171.794 1.00 107.79 ?  994  LYS   C N     1 
ATOM   6188 C CA    . LYS   A 1 994  ? 124.683 67.165  173.024 1.00 110.22 ?  994  LYS   C CA    1 
ATOM   6189 C C     . LYS   A 1 994  ? 124.749 65.672  172.731 1.00 112.61 ?  994  LYS   C C     1 
ATOM   6190 O O     . LYS   A 1 994  ? 124.988 64.865  173.632 1.00 113.69 ?  994  LYS   C O     1 
ATOM   6191 C CB    . LYS   A 1 994  ? 123.412 67.470  173.811 1.00 113.43 ?  994  LYS   C CB    1 
ATOM   6192 C CG    . LYS   A 1 994  ? 123.326 68.880  174.361 1.00 110.62 ?  994  LYS   C CG    1 
ATOM   6193 C CD    . LYS   A 1 994  ? 121.973 69.125  175.010 1.00 110.95 ?  994  LYS   C CD    1 
ATOM   6194 C CE    . LYS   A 1 994  ? 121.820 70.563  175.470 1.00 114.15 ?  994  LYS   C CE    1 
ATOM   6195 N NZ    . LYS   A 1 994  ? 120.454 70.823  176.006 1.00 115.69 1  994  LYS   C NZ    1 
ATOM   6196 N N     . GLN   A 1 995  ? 124.518 65.299  171.473 1.00 116.06 ?  995  GLN   C N     1 
ATOM   6197 C CA    . GLN   A 1 995  ? 124.454 63.893  171.094 1.00 115.27 ?  995  GLN   C CA    1 
ATOM   6198 C C     . GLN   A 1 995  ? 125.831 63.337  170.757 1.00 113.53 ?  995  GLN   C C     1 
ATOM   6199 O O     . GLN   A 1 995  ? 126.085 62.921  169.628 1.00 115.47 ?  995  GLN   C O     1 
ATOM   6200 C CB    . GLN   A 1 995  ? 123.516 63.716  169.897 1.00 117.90 ?  995  GLN   C CB    1 
ATOM   6201 C CG    . GLN   A 1 995  ? 122.100 64.204  170.145 1.00 119.85 ?  995  GLN   C CG    1 
ATOM   6202 C CD    . GLN   A 1 995  ? 121.425 63.453  171.263 1.00 127.01 ?  995  GLN   C CD    1 
ATOM   6203 O OE1   . GLN   A 1 995  ? 121.280 62.230  171.199 1.00 121.76 ?  995  GLN   C OE1   1 
ATOM   6204 N NE2   . GLN   A 1 995  ? 121.006 64.173  172.298 1.00 122.14 ?  995  GLN   C NE2   1 
ATOM   6205 N N     . GLN   A 1 996  ? 126.713 63.328  171.752 1.00 116.12 ?  996  GLN   C N     1 
ATOM   6206 C CA    . GLN   A 1 996  ? 128.074 62.814  171.601 1.00 114.76 ?  996  GLN   C CA    1 
ATOM   6207 C C     . GLN   A 1 996  ? 128.783 63.394  170.379 1.00 109.48 ?  996  GLN   C C     1 
ATOM   6208 O O     . GLN   A 1 996  ? 129.364 62.653  169.586 1.00 107.63 ?  996  GLN   C O     1 
ATOM   6209 C CB    . GLN   A 1 996  ? 128.068 61.283  171.505 1.00 116.41 ?  996  GLN   C CB    1 
ATOM   6210 C CG    . GLN   A 1 996  ? 127.566 60.570  172.750 1.00 123.06 ?  996  GLN   C CG    1 
ATOM   6211 C CD    . GLN   A 1 996  ? 128.527 60.690  173.914 1.00 129.13 ?  996  GLN   C CD    1 
ATOM   6212 O OE1   . GLN   A 1 996  ? 129.674 60.244  173.845 1.00 121.71 ?  996  GLN   C OE1   1 
ATOM   6213 N NE2   . GLN   A 1 996  ? 128.061 61.297  174.996 1.00 127.77 ?  996  GLN   C NE2   1 
ATOM   6214 N N     . SER   A 1 997  ? 128.737 64.713  170.228 1.00 107.59 ?  997  SER   C N     1 
ATOM   6215 C CA    . SER   A 1 997  ? 129.381 65.376  169.099 1.00 102.59 ?  997  SER   C CA    1 
ATOM   6216 C C     . SER   A 1 997  ? 130.893 65.262  169.159 1.00 92.33  ?  997  SER   C C     1 
ATOM   6217 O O     . SER   A 1 997  ? 131.487 65.282  170.237 1.00 91.56  ?  997  SER   C O     1 
ATOM   6218 C CB    . SER   A 1 997  ? 129.000 66.837  169.044 1.00 97.61  ?  997  SER   C CB    1 
ATOM   6219 O OG    . SER   A 1 997  ? 129.758 67.510  168.070 1.00 92.01  ?  997  SER   C OG    1 
ATOM   6220 N N     . CYS   A 1 998  ? 131.518 65.161  167.990 1.00 88.19  ?  998  CYS   C N     1 
ATOM   6221 C CA    . CYS   A 1 998  ? 132.971 65.099  167.907 1.00 83.91  ?  998  CYS   C CA    1 
ATOM   6222 C C     . CYS   A 1 998  ? 133.575 66.490  167.778 1.00 79.38  ?  998  CYS   C C     1 
ATOM   6223 O O     . CYS   A 1 998  ? 134.796 66.646  167.775 1.00 76.86  ?  998  CYS   C O     1 
ATOM   6224 C CB    . CYS   A 1 998  ? 133.406 64.248  166.719 1.00 85.17  ?  998  CYS   C CB    1 
ATOM   6225 S SG    . CYS   A 1 998  ? 133.043 64.988  165.115 1.00 86.38  ?  998  CYS   C SG    1 
ATOM   6226 N N     . LEU   A 1 999  ? 132.720 67.502  167.668 1.00 77.53  ?  999  LEU   C N     1 
ATOM   6227 C CA    . LEU   A 1 999  ? 133.201 68.870  167.559 1.00 75.34  ?  999  LEU   C CA    1 
ATOM   6228 C C     . LEU   A 1 999  ? 133.557 69.369  168.946 1.00 81.94  ?  999  LEU   C C     1 
ATOM   6229 O O     . LEU   A 1 999  ? 132.717 69.370  169.848 1.00 87.79  ?  999  LEU   C O     1 
ATOM   6230 C CB    . LEU   A 1 999  ? 132.133 69.772  166.917 1.00 73.32  ?  999  LEU   C CB    1 
ATOM   6231 C CG    . LEU   A 1 999  ? 132.577 71.211  166.548 1.00 72.43  ?  999  LEU   C CG    1 
ATOM   6232 C CD1   . LEU   A 1 999  ? 131.777 71.697  165.363 1.00 72.48  ?  999  LEU   C CD1   1 
ATOM   6233 C CD2   . LEU   A 1 999  ? 132.347 72.145  167.728 1.00 72.61  ?  999  LEU   C CD2   1 
ATOM   6234 N N     . LEU   A 1 1000 ? 134.813 69.756  169.125 1.00 79.25  ?  1000 LEU   C N     1 
ATOM   6235 C CA    . LEU   A 1 1000 ? 135.302 70.170  170.435 1.00 83.31  ?  1000 LEU   C CA    1 
ATOM   6236 C C     . LEU   A 1 1000 ? 135.717 71.634  170.453 1.00 81.93  ?  1000 LEU   C C     1 
ATOM   6237 O O     . LEU   A 1 1000 ? 135.771 72.270  171.509 1.00 86.98  ?  1000 LEU   C O     1 
ATOM   6238 C CB    . LEU   A 1 1000 ? 136.494 69.294  170.835 1.00 85.43  ?  1000 LEU   C CB    1 
ATOM   6239 C CG    . LEU   A 1 1000 ? 136.234 67.769  170.865 1.00 89.89  ?  1000 LEU   C CG    1 
ATOM   6240 C CD1   . LEU   A 1 1000 ? 137.541 67.045  171.145 1.00 93.65  ?  1000 LEU   C CD1   1 
ATOM   6241 C CD2   . LEU   A 1 1000 ? 135.196 67.438  171.931 1.00 96.04  ?  1000 LEU   C CD2   1 
ATOM   6242 N N     . GLN   A 1 1001 ? 136.055 72.156  169.283 1.00 73.23  ?  1001 GLN   C N     1 
ATOM   6243 C CA    . GLN   A 1 1001 ? 136.613 73.489  169.179 1.00 71.80  ?  1001 GLN   C CA    1 
ATOM   6244 C C     . GLN   A 1 1001 ? 135.554 74.550  168.971 1.00 69.82  ?  1001 GLN   C C     1 
ATOM   6245 O O     . GLN   A 1 1001 ? 134.361 74.263  168.922 1.00 71.26  ?  1001 GLN   C O     1 
ATOM   6246 C CB    . GLN   A 1 1001 ? 137.616 73.549  168.042 1.00 77.39  ?  1001 GLN   C CB    1 
ATOM   6247 C CG    . GLN   A 1 1001 ? 138.749 72.560  168.166 1.00 82.04  ?  1001 GLN   C CG    1 
ATOM   6248 C CD    . GLN   A 1 1001 ? 139.523 72.753  169.441 1.00 88.89  ?  1001 GLN   C CD    1 
ATOM   6249 O OE1   . GLN   A 1 1001 ? 139.830 73.884  169.826 1.00 87.53  ?  1001 GLN   C OE1   1 
ATOM   6250 N NE2   . GLN   A 1 1001 ? 139.851 71.656  170.107 1.00 84.65  ?  1001 GLN   C NE2   1 
ATOM   6251 N N     . ASN   A 1 1002 ? 136.007 75.790  168.870 1.00 72.87  ?  1002 ASN   C N     1 
ATOM   6252 C CA    . ASN   A 1 1002 ? 135.129 76.941  168.752 1.00 74.25  ?  1002 ASN   C CA    1 
ATOM   6253 C C     . ASN   A 1 1002 ? 133.997 76.700  167.761 1.00 66.31  ?  1002 ASN   C C     1 
ATOM   6254 O O     . ASN   A 1 1002 ? 134.230 76.382  166.596 1.00 65.40  ?  1002 ASN   C O     1 
ATOM   6255 C CB    . ASN   A 1 1002 ? 135.945 78.164  168.362 1.00 77.53  ?  1002 ASN   C CB    1 
ATOM   6256 C CG    . ASN   A 1 1002 ? 135.211 79.460  168.559 1.00 81.96  ?  1002 ASN   C CG    1 
ATOM   6257 O OD1   . ASN   A 1 1002 ? 133.978 79.499  168.585 1.00 78.15  ?  1002 ASN   C OD1   1 
ATOM   6258 N ND2   . ASN   A 1 1002 ? 135.955 80.532  168.694 1.00 78.62  ?  1002 ASN   C ND2   1 
ATOM   6259 N N     . LEU   A 1 1003 ? 132.770 76.876  168.247 1.00 68.03  ?  1003 LEU   C N     1 
ATOM   6260 C CA    . LEU   A 1 1003 ? 131.552 76.697  167.456 1.00 62.57  ?  1003 LEU   C CA    1 
ATOM   6261 C C     . LEU   A 1 1003 ? 131.288 77.880  166.525 1.00 57.37  ?  1003 LEU   C C     1 
ATOM   6262 O O     . LEU   A 1 1003 ? 130.452 77.795  165.624 1.00 60.90  ?  1003 LEU   C O     1 
ATOM   6263 C CB    . LEU   A 1 1003 ? 130.348 76.507  168.394 1.00 70.98  ?  1003 LEU   C CB    1 
ATOM   6264 C CG    . LEU   A 1 1003 ? 128.990 76.127  167.745 1.00 71.79  ?  1003 LEU   C CG    1 
ATOM   6265 C CD1   . LEU   A 1 1003 ? 129.111 74.779  167.012 1.00 75.01  ?  1003 LEU   C CD1   1 
ATOM   6266 C CD2   . LEU   A 1 1003 ? 127.931 76.064  168.843 1.00 80.85  ?  1003 LEU   C CD2   1 
ATOM   6267 N N     . GLY   A 1 1004 ? 131.983 78.987  166.758 1.00 57.81  ?  1004 GLY   C N     1 
ATOM   6268 C CA    . GLY   A 1 1004 ? 131.809 80.187  165.947 1.00 58.69  ?  1004 GLY   C CA    1 
ATOM   6269 C C     . GLY   A 1 1004 ? 130.544 80.954  166.311 1.00 61.09  ?  1004 GLY   C C     1 
ATOM   6270 O O     . GLY   A 1 1004 ? 130.286 81.211  167.481 1.00 65.31  ?  1004 GLY   C O     1 
ATOM   6271 N N     . LEU   A 1 1005 ? 129.779 81.341  165.291 1.00 56.04  ?  1005 LEU   C N     1 
ATOM   6272 C CA    . LEU   A 1 1005 ? 128.603 82.199  165.451 1.00 56.45  ?  1005 LEU   C CA    1 
ATOM   6273 C C     . LEU   A 1 1005 ? 129.070 83.606  165.807 1.00 57.29  ?  1005 LEU   C C     1 
ATOM   6274 O O     . LEU   A 1 1005 ? 128.393 84.349  166.526 1.00 59.73  ?  1005 LEU   C O     1 
ATOM   6275 C CB    . LEU   A 1 1005 ? 127.671 81.668  166.557 1.00 54.07  ?  1005 LEU   C CB    1 
ATOM   6276 C CG    . LEU   A 1 1005 ? 127.308 80.156  166.507 1.00 55.23  ?  1005 LEU   C CG    1 
ATOM   6277 C CD1   . LEU   A 1 1005 ? 126.441 79.826  167.710 1.00 69.45  ?  1005 LEU   C CD1   1 
ATOM   6278 C CD2   . LEU   A 1 1005 ? 126.586 79.824  165.219 1.00 64.78  ?  1005 LEU   C CD2   1 
ATOM   6279 N N     . SER   A 1 1006 ? 130.250 83.953  165.310 1.00 57.98  ?  1006 SER   C N     1 
ATOM   6280 C CA    . SER   A 1 1006 ? 130.881 85.230  165.610 1.00 58.30  ?  1006 SER   C CA    1 
ATOM   6281 C C     . SER   A 1 1006 ? 130.082 86.390  165.052 1.00 56.36  ?  1006 SER   C C     1 
ATOM   6282 O O     . SER   A 1 1006 ? 129.532 86.313  163.958 1.00 58.30  ?  1006 SER   C O     1 
ATOM   6283 C CB    . SER   A 1 1006 ? 132.281 85.268  165.031 1.00 66.61  ?  1006 SER   C CB    1 
ATOM   6284 O OG    . SER   A 1 1006 ? 133.091 84.267  165.587 1.00 67.41  ?  1006 SER   C OG    1 
ATOM   6285 N N     . GLU   A 1 1007 ? 130.039 87.477  165.811 1.00 57.90  ?  1007 GLU   C N     1 
ATOM   6286 C CA    . GLU   A 1 1007 ? 129.397 88.714  165.379 1.00 60.77  ?  1007 GLU   C CA    1 
ATOM   6287 C C     . GLU   A 1 1007 ? 127.912 88.544  165.101 1.00 60.19  ?  1007 GLU   C C     1 
ATOM   6288 O O     . GLU   A 1 1007 ? 127.271 89.445  164.557 1.00 63.26  ?  1007 GLU   C O     1 
ATOM   6289 C CB    . GLU   A 1 1007 ? 130.084 89.267  164.130 1.00 62.38  ?  1007 GLU   C CB    1 
ATOM   6290 C CG    . GLU   A 1 1007 ? 131.597 89.379  164.246 1.00 74.66  ?  1007 GLU   C CG    1 
ATOM   6291 C CD    . GLU   A 1 1007 ? 132.028 90.234  165.399 1.00 84.07  ?  1007 GLU   C CD    1 
ATOM   6292 O OE1   . GLU   A 1 1007 ? 131.359 91.198  165.684 1.00 84.07  ?  1007 GLU   C OE1   1 
ATOM   6293 O OE2   . GLU   A 1 1007 ? 133.025 89.918  166.004 1.00 81.71  -1 1007 GLU   C OE2   1 
ATOM   6294 N N     . MET   A 1 1008 ? 127.348 87.412  165.494 1.00 59.31  ?  1008 MET   C N     1 
ATOM   6295 C CA    . MET   A 1 1008 ? 125.926 87.195  165.333 1.00 61.65  ?  1008 MET   C CA    1 
ATOM   6296 C C     . MET   A 1 1008 ? 125.245 87.421  166.666 1.00 67.01  ?  1008 MET   C C     1 
ATOM   6297 O O     . MET   A 1 1008 ? 125.754 87.005  167.705 1.00 70.18  ?  1008 MET   C O     1 
ATOM   6298 C CB    . MET   A 1 1008 ? 125.664 85.804  164.778 1.00 59.15  ?  1008 MET   C CB    1 
ATOM   6299 C CG    . MET   A 1 1008 ? 124.212 85.500  164.519 1.00 65.06  ?  1008 MET   C CG    1 
ATOM   6300 S SD    . MET   A 1 1008 ? 123.983 84.111  163.396 1.00 78.19  ?  1008 MET   C SD    1 
ATOM   6301 C CE    . MET   A 1 1008 ? 124.827 82.765  164.196 1.00 66.57  ?  1008 MET   C CE    1 
ATOM   6302 N N     . TYR   A 1 1009 ? 124.122 88.118  166.645 1.00 62.42  ?  1009 TYR   C N     1 
ATOM   6303 C CA    . TYR   A 1 1009 ? 123.442 88.479  167.875 1.00 62.10  ?  1009 TYR   C CA    1 
ATOM   6304 C C     . TYR   A 1 1009 ? 122.076 87.840  167.955 1.00 62.50  ?  1009 TYR   C C     1 
ATOM   6305 O O     . TYR   A 1 1009 ? 121.471 87.516  166.933 1.00 66.82  ?  1009 TYR   C O     1 
ATOM   6306 C CB    . TYR   A 1 1009 ? 123.360 89.994  167.985 1.00 58.67  ?  1009 TYR   C CB    1 
ATOM   6307 C CG    . TYR   A 1 1009 ? 124.728 90.612  168.010 1.00 62.39  ?  1009 TYR   C CG    1 
ATOM   6308 C CD1   . TYR   A 1 1009 ? 125.370 90.893  166.821 1.00 63.81  ?  1009 TYR   C CD1   1 
ATOM   6309 C CD2   . TYR   A 1 1009 ? 125.353 90.880  169.214 1.00 72.28  ?  1009 TYR   C CD2   1 
ATOM   6310 C CE1   . TYR   A 1 1009 ? 126.631 91.438  166.828 1.00 70.16  ?  1009 TYR   C CE1   1 
ATOM   6311 C CE2   . TYR   A 1 1009 ? 126.622 91.429  169.221 1.00 77.27  ?  1009 TYR   C CE2   1 
ATOM   6312 C CZ    . TYR   A 1 1009 ? 127.259 91.703  168.030 1.00 73.21  ?  1009 TYR   C CZ    1 
ATOM   6313 O OH    . TYR   A 1 1009 ? 128.523 92.244  168.029 1.00 73.14  ?  1009 TYR   C OH    1 
ATOM   6314 N N     . PHE   A 1 1010 ? 121.603 87.630  169.173 1.00 64.61  ?  1010 PHE   C N     1 
ATOM   6315 C CA    . PHE   A 1 1010 ? 120.366 86.902  169.378 1.00 72.20  ?  1010 PHE   C CA    1 
ATOM   6316 C C     . PHE   A 1 1010 ? 119.511 87.529  170.456 1.00 78.15  ?  1010 PHE   C C     1 
ATOM   6317 O O     . PHE   A 1 1010 ? 119.892 88.525  171.074 1.00 75.39  ?  1010 PHE   C O     1 
ATOM   6318 C CB    . PHE   A 1 1010 ? 120.668 85.485  169.816 1.00 75.25  ?  1010 PHE   C CB    1 
ATOM   6319 C CG    . PHE   A 1 1010 ? 121.724 84.844  169.044 1.00 72.66  ?  1010 PHE   C CG    1 
ATOM   6320 C CD1   . PHE   A 1 1010 ? 123.012 84.836  169.536 1.00 73.02  ?  1010 PHE   C CD1   1 
ATOM   6321 C CD2   . PHE   A 1 1010 ? 121.464 84.256  167.838 1.00 73.72  ?  1010 PHE   C CD2   1 
ATOM   6322 C CE1   . PHE   A 1 1010 ? 124.022 84.245  168.838 1.00 74.28  ?  1010 PHE   C CE1   1 
ATOM   6323 C CE2   . PHE   A 1 1010 ? 122.467 83.666  167.139 1.00 75.11  ?  1010 PHE   C CE2   1 
ATOM   6324 C CZ    . PHE   A 1 1010 ? 123.756 83.659  167.645 1.00 75.83  ?  1010 PHE   C CZ    1 
ATOM   6325 N N     . ASN   A 1 1011 ? 118.359 86.919  170.693 1.00 81.69  ?  1011 ASN   C N     1 
ATOM   6326 C CA    . ASN   A 1 1011 ? 117.493 87.313  171.790 1.00 87.78  ?  1011 ASN   C CA    1 
ATOM   6327 C C     . ASN   A 1 1011 ? 117.983 86.666  173.079 1.00 89.75  ?  1011 ASN   C C     1 
ATOM   6328 O O     . ASN   A 1 1011 ? 119.009 85.980  173.088 1.00 86.93  ?  1011 ASN   C O     1 
ATOM   6329 C CB    . ASN   A 1 1011 ? 116.051 86.942  171.495 1.00 94.46  ?  1011 ASN   C CB    1 
ATOM   6330 C CG    . ASN   A 1 1011 ? 115.848 85.456  171.376 1.00 92.73  ?  1011 ASN   C CG    1 
ATOM   6331 O OD1   . ASN   A 1 1011 ? 116.706 84.661  171.783 1.00 86.66  ?  1011 ASN   C OD1   1 
ATOM   6332 N ND2   . ASN   A 1 1011 ? 114.729 85.067  170.818 1.00 95.49  ?  1011 ASN   C ND2   1 
ATOM   6333 N N     . TYR   A 1 1012 ? 117.264 86.893  174.169 1.00 95.15  ?  1012 TYR   C N     1 
ATOM   6334 C CA    . TYR   A 1 1012 ? 117.707 86.405  175.467 1.00 98.72  ?  1012 TYR   C CA    1 
ATOM   6335 C C     . TYR   A 1 1012 ? 117.559 84.895  175.605 1.00 95.06  ?  1012 TYR   C C     1 
ATOM   6336 O O     . TYR   A 1 1012 ? 118.363 84.250  176.281 1.00 95.28  ?  1012 TYR   C O     1 
ATOM   6337 C CB    . TYR   A 1 1012 ? 116.935 87.116  176.574 1.00 111.01 ?  1012 TYR   C CB    1 
ATOM   6338 C CG    . TYR   A 1 1012 ? 117.304 88.579  176.727 1.00 122.44 ?  1012 TYR   C CG    1 
ATOM   6339 C CD1   . TYR   A 1 1012 ? 116.475 89.565  176.207 1.00 134.18 ?  1012 TYR   C CD1   1 
ATOM   6340 C CD2   . TYR   A 1 1012 ? 118.468 88.934  177.395 1.00 122.96 ?  1012 TYR   C CD2   1 
ATOM   6341 C CE1   . TYR   A 1 1012 ? 116.810 90.899  176.355 1.00 139.22 ?  1012 TYR   C CE1   1 
ATOM   6342 C CE2   . TYR   A 1 1012 ? 118.802 90.269  177.539 1.00 129.62 ?  1012 TYR   C CE2   1 
ATOM   6343 C CZ    . TYR   A 1 1012 ? 117.977 91.248  177.025 1.00 138.02 ?  1012 TYR   C CZ    1 
ATOM   6344 O OH    . TYR   A 1 1012 ? 118.310 92.576  177.174 1.00 130.02 ?  1012 TYR   C OH    1 
ATOM   6345 N N     . GLU   A 1 1013 ? 116.537 84.328  174.972 1.00 91.87  ?  1013 GLU   C N     1 
ATOM   6346 C CA    . GLU   A 1 1013 ? 116.309 82.891  175.065 1.00 92.17  ?  1013 GLU   C CA    1 
ATOM   6347 C C     . GLU   A 1 1013 ? 117.465 82.114  174.449 1.00 92.78  ?  1013 GLU   C C     1 
ATOM   6348 O O     . GLU   A 1 1013 ? 117.963 81.151  175.034 1.00 95.20  ?  1013 GLU   C O     1 
ATOM   6349 C CB    . GLU   A 1 1013 ? 114.999 82.504  174.382 1.00 93.23  ?  1013 GLU   C CB    1 
ATOM   6350 C CG    . GLU   A 1 1013 ? 114.670 81.023  174.466 1.00 97.48  ?  1013 GLU   C CG    1 
ATOM   6351 C CD    . GLU   A 1 1013 ? 113.342 80.688  173.861 1.00 103.01 ?  1013 GLU   C CD    1 
ATOM   6352 O OE1   . GLU   A 1 1013 ? 112.658 81.590  173.444 1.00 100.54 ?  1013 GLU   C OE1   1 
ATOM   6353 O OE2   . GLU   A 1 1013 ? 113.008 79.528  173.814 1.00 101.71 -1 1013 GLU   C OE2   1 
ATOM   6354 N N     . THR   A 1 1014 ? 117.904 82.556  173.275 1.00 90.48  ?  1014 THR   C N     1 
ATOM   6355 C CA    . THR   A 1 1014 ? 119.022 81.924  172.592 1.00 91.34  ?  1014 THR   C CA    1 
ATOM   6356 C C     . THR   A 1 1014 ? 120.310 82.088  173.381 1.00 94.90  ?  1014 THR   C C     1 
ATOM   6357 O O     . THR   A 1 1014 ? 121.093 81.141  173.498 1.00 94.65  ?  1014 THR   C O     1 
ATOM   6358 C CB    . THR   A 1 1014 ? 119.199 82.498  171.180 1.00 86.26  ?  1014 THR   C CB    1 
ATOM   6359 O OG1   . THR   A 1 1014 ? 118.031 82.218  170.396 1.00 85.47  ?  1014 THR   C OG1   1 
ATOM   6360 C CG2   . THR   A 1 1014 ? 120.414 81.876  170.501 1.00 91.35  ?  1014 THR   C CG2   1 
ATOM   6361 N N     . LYS   A 1 1015 ? 120.547 83.282  173.924 1.00 91.81  ?  1015 LYS   C N     1 
ATOM   6362 C CA    . LYS   A 1 1015 ? 121.756 83.506  174.702 1.00 92.25  ?  1015 LYS   C CA    1 
ATOM   6363 C C     . LYS   A 1 1015 ? 121.810 82.565  175.897 1.00 95.27  ?  1015 LYS   C C     1 
ATOM   6364 O O     . LYS   A 1 1015 ? 122.858 82.004  176.202 1.00 98.80  ?  1015 LYS   C O     1 
ATOM   6365 C CB    . LYS   A 1 1015 ? 121.854 84.955  175.172 1.00 89.64  ?  1015 LYS   C CB    1 
ATOM   6366 C CG    . LYS   A 1 1015 ? 122.188 85.957  174.078 1.00 84.26  ?  1015 LYS   C CG    1 
ATOM   6367 C CD    . LYS   A 1 1015 ? 122.239 87.375  174.632 1.00 83.98  ?  1015 LYS   C CD    1 
ATOM   6368 C CE    . LYS   A 1 1015 ? 122.609 88.381  173.554 1.00 77.22  ?  1015 LYS   C CE    1 
ATOM   6369 N NZ    . LYS   A 1 1015 ? 122.662 89.772  174.087 1.00 71.57  1  1015 LYS   C NZ    1 
ATOM   6370 N N     . SER   A 1 1016 ? 120.664 82.378  176.550 1.00 96.26  ?  1016 SER   C N     1 
ATOM   6371 C CA    . SER   A 1 1016 ? 120.602 81.475  177.696 1.00 101.88 ?  1016 SER   C CA    1 
ATOM   6372 C C     . SER   A 1 1016 ? 120.935 80.061  177.272 1.00 100.03 ?  1016 SER   C C     1 
ATOM   6373 O O     . SER   A 1 1016 ? 121.694 79.357  177.969 1.00 102.41 ?  1016 SER   C O     1 
ATOM   6374 C CB    . SER   A 1 1016 ? 119.212 81.517  178.308 1.00 104.39 ?  1016 SER   C CB    1 
ATOM   6375 O OG    . SER   A 1 1016 ? 119.129 80.657  179.412 1.00 104.00 ?  1016 SER   C OG    1 
ATOM   6376 N N     . ALA   A 1 1017 ? 120.402 79.612  176.149 1.00 97.19  ?  1017 ALA   C N     1 
ATOM   6377 C CA    . ALA   A 1 1017 ? 120.671 78.297  175.626 1.00 96.22  ?  1017 ALA   C CA    1 
ATOM   6378 C C     . ALA   A 1 1017 ? 122.164 78.086  175.352 1.00 95.38  ?  1017 ALA   C C     1 
ATOM   6379 O O     . ALA   A 1 1017 ? 122.725 77.055  175.644 1.00 101.73 ?  1017 ALA   C O     1 
ATOM   6380 C CB    . ALA   A 1 1017 ? 119.864 78.018  174.385 1.00 99.94  ?  1017 ALA   C CB    1 
ATOM   6381 N N     . LEU   A 1 1018 ? 122.788 79.137  174.782 1.00 95.47  ?  1018 LEU   C N     1 
ATOM   6382 C CA    . LEU   A 1 1018 ? 124.222 79.051  174.483 1.00 97.02  ?  1018 LEU   C CA    1 
ATOM   6383 C C     . LEU   A 1 1018 ? 125.058 79.001  175.751 1.00 103.60 ?  1018 LEU   C C     1 
ATOM   6384 O O     . LEU   A 1 1018 ? 126.008 78.207  175.834 1.00 98.55  ?  1018 LEU   C O     1 
ATOM   6385 C CB    . LEU   A 1 1018 ? 124.644 80.268  173.639 1.00 98.95  ?  1018 LEU   C CB    1 
ATOM   6386 C CG    . LEU   A 1 1018 ? 124.158 80.287  172.176 1.00 96.77  ?  1018 LEU   C CG    1 
ATOM   6387 C CD1   . LEU   A 1 1018 ? 124.435 81.661  171.573 1.00 87.04  ?  1018 LEU   C CD1   1 
ATOM   6388 C CD2   . LEU   A 1 1018 ? 124.888 79.210  171.387 1.00 92.44  ?  1018 LEU   C CD2   1 
ATOM   6389 N N     . GLU   A 1 1019 ? 124.700 79.786  176.758 1.00 99.88  ?  1019 GLU   C N     1 
ATOM   6390 C CA    . GLU   A 1 1019 ? 125.415 79.749  178.022 1.00 103.97 ?  1019 GLU   C CA    1 
ATOM   6391 C C     . GLU   A 1 1019 ? 125.248 78.381  178.665 1.00 101.84 ?  1019 GLU   C C     1 
ATOM   6392 O O     . GLU   A 1 1019 ? 126.192 77.818  179.221 1.00 105.55 ?  1019 GLU   C O     1 
ATOM   6393 C CB    . GLU   A 1 1019 ? 124.917 80.834  178.976 1.00 107.32 ?  1019 GLU   C CB    1 
ATOM   6394 C CG    . GLU   A 1 1019 ? 125.284 82.257  178.578 1.00 110.03 ?  1019 GLU   C CG    1 
ATOM   6395 C CD    . GLU   A 1 1019 ? 124.717 83.281  179.523 1.00 114.70 ?  1019 GLU   C CD    1 
ATOM   6396 O OE1   . GLU   A 1 1019 ? 123.948 82.908  180.375 1.00 109.87 ?  1019 GLU   C OE1   1 
ATOM   6397 O OE2   . GLU   A 1 1019 ? 125.054 84.433  179.396 1.00 113.06 -1 1019 GLU   C OE2   1 
ATOM   6398 N N     . THR   A 1 1020 ? 124.037 77.839  178.558 1.00 104.59 ?  1020 THR   C N     1 
ATOM   6399 C CA    . THR   A 1 1020 ? 123.749 76.524  179.099 1.00 103.95 ?  1020 THR   C CA    1 
ATOM   6400 C C     . THR   A 1 1020 ? 124.626 75.498  178.413 1.00 105.26 ?  1020 THR   C C     1 
ATOM   6401 O O     . THR   A 1 1020 ? 125.235 74.658  179.070 1.00 108.89 ?  1020 THR   C O     1 
ATOM   6402 C CB    . THR   A 1 1020 ? 122.266 76.155  178.904 1.00 107.24 ?  1020 THR   C CB    1 
ATOM   6403 O OG1   . THR   A 1 1020 ? 121.443 77.106  179.593 1.00 107.92 ?  1020 THR   C OG1   1 
ATOM   6404 C CG2   . THR   A 1 1020 ? 121.993 74.759  179.451 1.00 107.47 ?  1020 THR   C CG2   1 
ATOM   6405 N N     . LEU   A 1 1021 ? 124.716 75.584  177.091 1.00 104.57 ?  1021 LEU   C N     1 
ATOM   6406 C CA    . LEU   A 1 1021 ? 125.528 74.663  176.313 1.00 108.62 ?  1021 LEU   C CA    1 
ATOM   6407 C C     . LEU   A 1 1021 ? 126.982 74.685  176.772 1.00 104.55 ?  1021 LEU   C C     1 
ATOM   6408 O O     . LEU   A 1 1021 ? 127.597 73.634  176.960 1.00 110.27 ?  1021 LEU   C O     1 
ATOM   6409 C CB    . LEU   A 1 1021 ? 125.454 75.044  174.826 1.00 105.79 ?  1021 LEU   C CB    1 
ATOM   6410 C CG    . LEU   A 1 1021 ? 126.279 74.196  173.839 1.00 109.81 ?  1021 LEU   C CG    1 
ATOM   6411 C CD1   . LEU   A 1 1021 ? 125.747 72.755  173.809 1.00 107.56 ?  1021 LEU   C CD1   1 
ATOM   6412 C CD2   . LEU   A 1 1021 ? 126.206 74.849  172.461 1.00 106.18 ?  1021 LEU   C CD2   1 
ATOM   6413 N N     . GLN   A 1 1022 ? 127.525 75.885  176.979 1.00 102.69 ?  1022 GLN   C N     1 
ATOM   6414 C CA    . GLN   A 1 1022 ? 128.921 76.015  177.381 1.00 107.79 ?  1022 GLN   C CA    1 
ATOM   6415 C C     . GLN   A 1 1022 ? 129.213 75.289  178.690 1.00 108.63 ?  1022 GLN   C C     1 
ATOM   6416 O O     . GLN   A 1 1022 ? 130.275 74.684  178.846 1.00 108.03 ?  1022 GLN   C O     1 
ATOM   6417 C CB    . GLN   A 1 1022 ? 129.307 77.492  177.549 1.00 104.06 ?  1022 GLN   C CB    1 
ATOM   6418 C CG    . GLN   A 1 1022 ? 130.794 77.717  177.860 1.00 100.18 ?  1022 GLN   C CG    1 
ATOM   6419 C CD    . GLN   A 1 1022 ? 131.693 77.367  176.688 1.00 102.17 ?  1022 GLN   C CD    1 
ATOM   6420 O OE1   . GLN   A 1 1022 ? 131.895 78.192  175.782 1.00 97.83  ?  1022 GLN   C OE1   1 
ATOM   6421 N NE2   . GLN   A 1 1022 ? 132.224 76.148  176.700 1.00 102.17 ?  1022 GLN   C NE2   1 
ATOM   6422 N N     . GLU   A 1 1023 ? 128.282 75.356  179.637 1.00 110.92 ?  1023 GLU   C N     1 
ATOM   6423 C CA    . GLU   A 1 1023 ? 128.490 74.720  180.934 1.00 114.07 ?  1023 GLU   C CA    1 
ATOM   6424 C C     . GLU   A 1 1023 ? 128.029 73.263  180.964 1.00 112.33 ?  1023 GLU   C C     1 
ATOM   6425 O O     . GLU   A 1 1023 ? 128.615 72.435  181.665 1.00 113.57 ?  1023 GLU   C O     1 
ATOM   6426 C CB    . GLU   A 1 1023 ? 127.769 75.506  182.034 1.00 121.00 ?  1023 GLU   C CB    1 
ATOM   6427 C CG    . GLU   A 1 1023 ? 128.344 76.896  182.303 1.00 123.79 ?  1023 GLU   C CG    1 
ATOM   6428 C CD    . GLU   A 1 1023 ? 127.665 77.603  183.452 1.00 130.82 ?  1023 GLU   C CD    1 
ATOM   6429 O OE1   . GLU   A 1 1023 ? 126.733 77.057  183.992 1.00 126.23 ?  1023 GLU   C OE1   1 
ATOM   6430 O OE2   . GLU   A 1 1023 ? 128.083 78.687  183.788 1.00 129.52 -1 1023 GLU   C OE2   1 
ATOM   6431 N N     . GLU   A 1 1024 ? 126.976 72.955  180.214 1.00 110.66 ?  1024 GLU   C N     1 
ATOM   6432 C CA    . GLU   A 1 1024 ? 126.380 71.626  180.219 1.00 114.39 ?  1024 GLU   C CA    1 
ATOM   6433 C C     . GLU   A 1 1024 ? 127.298 70.597  179.585 1.00 116.20 ?  1024 GLU   C C     1 
ATOM   6434 O O     . GLU   A 1 1024 ? 127.384 69.461  180.054 1.00 116.75 ?  1024 GLU   C O     1 
ATOM   6435 C CB    . GLU   A 1 1024 ? 125.039 71.643  179.482 1.00 113.73 ?  1024 GLU   C CB    1 
ATOM   6436 C CG    . GLU   A 1 1024 ? 124.274 70.323  179.506 1.00 120.49 ?  1024 GLU   C CG    1 
ATOM   6437 C CD    . GLU   A 1 1024 ? 123.837 69.915  180.889 1.00 125.80 ?  1024 GLU   C CD    1 
ATOM   6438 O OE1   . GLU   A 1 1024 ? 123.852 70.744  181.767 1.00 117.87 ?  1024 GLU   C OE1   1 
ATOM   6439 O OE2   . GLU   A 1 1024 ? 123.486 68.772  181.065 1.00 124.59 -1 1024 GLU   C OE2   1 
ATOM   6440 N N     . LYS   A 1 1025 ? 127.988 70.994  178.517 1.00 113.68 ?  1025 LYS   C N     1 
ATOM   6441 C CA    . LYS   A 1 1025 ? 128.888 70.094  177.804 1.00 116.96 ?  1025 LYS   C CA    1 
ATOM   6442 C C     . LYS   A 1 1025 ? 130.281 70.697  177.625 1.00 110.24 ?  1025 LYS   C C     1 
ATOM   6443 O O     . LYS   A 1 1025 ? 130.585 71.210  176.547 1.00 108.72 ?  1025 LYS   C O     1 
ATOM   6444 C CB    . LYS   A 1 1025 ? 128.306 69.737  176.432 1.00 115.00 ?  1025 LYS   C CB    1 
ATOM   6445 C CG    . LYS   A 1 1025 ? 126.944 69.040  176.469 1.00 119.66 ?  1025 LYS   C CG    1 
ATOM   6446 C CD    . LYS   A 1 1025 ? 127.041 67.647  177.092 1.00 124.01 ?  1025 LYS   C CD    1 
ATOM   6447 C CE    . LYS   A 1 1025 ? 125.707 66.918  177.042 1.00 126.52 ?  1025 LYS   C CE    1 
ATOM   6448 N NZ    . LYS   A 1 1025 ? 125.767 65.601  177.737 1.00 135.83 1  1025 LYS   C NZ    1 
ATOM   6449 N N     . PRO   A 1 1026 ? 131.150 70.603  178.650 1.00 111.00 ?  1026 PRO   C N     1 
ATOM   6450 C CA    . PRO   A 1 1026 ? 132.489 71.170  178.745 1.00 109.16 ?  1026 PRO   C CA    1 
ATOM   6451 C C     . PRO   A 1 1026 ? 133.390 70.731  177.597 1.00 105.59 ?  1026 PRO   C C     1 
ATOM   6452 O O     . PRO   A 1 1026 ? 134.398 71.373  177.310 1.00 101.69 ?  1026 PRO   C O     1 
ATOM   6453 C CB    . PRO   A 1 1026 ? 133.000 70.603  180.076 1.00 109.44 ?  1026 PRO   C CB    1 
ATOM   6454 C CG    . PRO   A 1 1026 ? 131.757 70.301  180.866 1.00 115.03 ?  1026 PRO   C CG    1 
ATOM   6455 C CD    . PRO   A 1 1026 ? 130.746 69.856  179.844 1.00 113.30 ?  1026 PRO   C CD    1 
ATOM   6456 N N     . GLU   A 1 1027 ? 133.020 69.633  176.941 1.00 108.52 ?  1027 GLU   C N     1 
ATOM   6457 C CA    . GLU   A 1 1027 ? 133.785 69.121  175.816 1.00 104.98 ?  1027 GLU   C CA    1 
ATOM   6458 C C     . GLU   A 1 1027 ? 133.908 70.178  174.727 1.00 99.05  ?  1027 GLU   C C     1 
ATOM   6459 O O     . GLU   A 1 1027 ? 134.939 70.265  174.059 1.00 94.54  ?  1027 GLU   C O     1 
ATOM   6460 C CB    . GLU   A 1 1027 ? 133.128 67.858  175.263 1.00 110.75 ?  1027 GLU   C CB    1 
ATOM   6461 C CG    . GLU   A 1 1027 ? 133.236 66.654  176.186 1.00 110.35 ?  1027 GLU   C CG    1 
ATOM   6462 C CD    . GLU   A 1 1027 ? 132.214 66.663  177.292 1.00 116.56 ?  1027 GLU   C CD    1 
ATOM   6463 O OE1   . GLU   A 1 1027 ? 131.426 67.577  177.344 1.00 118.07 ?  1027 GLU   C OE1   1 
ATOM   6464 O OE2   . GLU   A 1 1027 ? 132.222 65.755  178.087 1.00 117.43 -1 1027 GLU   C OE2   1 
ATOM   6465 N N     . LEU   A 1 1028 ? 132.878 71.012  174.578 1.00 96.92  ?  1028 LEU   C N     1 
ATOM   6466 C CA    . LEU   A 1 1028 ? 132.943 72.111  173.628 1.00 92.48  ?  1028 LEU   C CA    1 
ATOM   6467 C C     . LEU   A 1 1028 ? 133.615 73.276  174.319 1.00 91.72  ?  1028 LEU   C C     1 
ATOM   6468 O O     . LEU   A 1 1028 ? 133.006 73.969  175.134 1.00 95.18  ?  1028 LEU   C O     1 
ATOM   6469 C CB    . LEU   A 1 1028 ? 131.540 72.515  173.159 1.00 88.19  ?  1028 LEU   C CB    1 
ATOM   6470 C CG    . LEU   A 1 1028 ? 131.458 73.725  172.192 1.00 83.29  ?  1028 LEU   C CG    1 
ATOM   6471 C CD1   . LEU   A 1 1028 ? 132.229 73.432  170.924 1.00 85.02  ?  1028 LEU   C CD1   1 
ATOM   6472 C CD2   . LEU   A 1 1028 ? 129.996 74.000  171.871 1.00 91.08  ?  1028 LEU   C CD2   1 
ATOM   6473 N N     . THR   A 1 1029 ? 134.890 73.460  174.020 1.00 94.27  ?  1029 THR   C N     1 
ATOM   6474 C CA    . THR   A 1 1029 ? 135.703 74.398  174.771 1.00 98.49  ?  1029 THR   C CA    1 
ATOM   6475 C C     . THR   A 1 1029 ? 135.184 75.817  174.620 1.00 96.89  ?  1029 THR   C C     1 
ATOM   6476 O O     . THR   A 1 1029 ? 135.150 76.576  175.587 1.00 99.43  ?  1029 THR   C O     1 
ATOM   6477 C CB    . THR   A 1 1029 ? 137.180 74.328  174.331 1.00 101.65 ?  1029 THR   C CB    1 
ATOM   6478 O OG1   . THR   A 1 1029 ? 137.672 72.997  174.528 1.00 100.49 ?  1029 THR   C OG1   1 
ATOM   6479 C CG2   . THR   A 1 1029 ? 138.024 75.281  175.171 1.00 103.54 ?  1029 THR   C CG2   1 
ATOM   6480 N N     . VAL   A 1 1030 ? 134.812 76.188  173.401 1.00 90.01  ?  1030 VAL   C N     1 
ATOM   6481 C CA    . VAL   A 1 1030 ? 134.334 77.537  173.156 1.00 88.00  ?  1030 VAL   C CA    1 
ATOM   6482 C C     . VAL   A 1 1030 ? 133.013 77.584  172.394 1.00 80.37  ?  1030 VAL   C C     1 
ATOM   6483 O O     . VAL   A 1 1030 ? 132.920 77.138  171.251 1.00 78.73  ?  1030 VAL   C O     1 
ATOM   6484 C CB    . VAL   A 1 1030 ? 135.398 78.347  172.378 1.00 88.91  ?  1030 VAL   C CB    1 
ATOM   6485 C CG1   . VAL   A 1 1030 ? 134.882 79.734  172.088 1.00 84.59  ?  1030 VAL   C CG1   1 
ATOM   6486 C CG2   . VAL   A 1 1030 ? 136.677 78.420  173.177 1.00 92.70  ?  1030 VAL   C CG2   1 
ATOM   6487 N N     . VAL   A 1 1031 ? 132.019 78.212  173.005 1.00 81.85  ?  1031 VAL   C N     1 
ATOM   6488 C CA    . VAL   A 1 1031 ? 130.758 78.493  172.331 1.00 81.01  ?  1031 VAL   C CA    1 
ATOM   6489 C C     . VAL   A 1 1031 ? 130.864 79.821  171.589 1.00 77.19  ?  1031 VAL   C C     1 
ATOM   6490 O O     . VAL   A 1 1031 ? 130.297 79.988  170.514 1.00 76.73  ?  1031 VAL   C O     1 
ATOM   6491 C CB    . VAL   A 1 1031 ? 129.582 78.514  173.324 1.00 93.18  ?  1031 VAL   C CB    1 
ATOM   6492 C CG1   . VAL   A 1 1031 ? 128.323 79.011  172.638 1.00 92.00  ?  1031 VAL   C CG1   1 
ATOM   6493 C CG2   . VAL   A 1 1031 ? 129.345 77.106  173.848 1.00 101.02 ?  1031 VAL   C CG2   1 
ATOM   6494 N N     . PHE   A 1 1032 ? 131.605 80.751  172.183 1.00 78.14  ?  1032 PHE   C N     1 
ATOM   6495 C CA    . PHE   A 1 1032 ? 131.869 82.078  171.624 1.00 77.13  ?  1032 PHE   C CA    1 
ATOM   6496 C C     . PHE   A 1 1032 ? 130.629 82.954  171.512 1.00 77.00  ?  1032 PHE   C C     1 
ATOM   6497 O O     . PHE   A 1 1032 ? 130.338 83.503  170.449 1.00 75.68  ?  1032 PHE   C O     1 
ATOM   6498 C CB    . PHE   A 1 1032 ? 132.515 81.959  170.243 1.00 75.00  ?  1032 PHE   C CB    1 
ATOM   6499 C CG    . PHE   A 1 1032 ? 133.241 83.193  169.804 1.00 81.12  ?  1032 PHE   C CG    1 
ATOM   6500 C CD1   . PHE   A 1 1032 ? 134.490 83.493  170.334 1.00 84.72  ?  1032 PHE   C CD1   1 
ATOM   6501 C CD2   . PHE   A 1 1032 ? 132.699 84.050  168.863 1.00 78.53  ?  1032 PHE   C CD2   1 
ATOM   6502 C CE1   . PHE   A 1 1032 ? 135.173 84.623  169.935 1.00 89.00  ?  1032 PHE   C CE1   1 
ATOM   6503 C CE2   . PHE   A 1 1032 ? 133.383 85.181  168.466 1.00 83.80  ?  1032 PHE   C CE2   1 
ATOM   6504 C CZ    . PHE   A 1 1032 ? 134.619 85.466  169.001 1.00 91.25  ?  1032 PHE   C CZ    1 
ATOM   6505 N N     . GLU   A 1 1033 ? 129.920 83.126  172.615 1.00 80.68  ?  1033 GLU   C N     1 
ATOM   6506 C CA    . GLU   A 1 1033 ? 128.794 84.043  172.634 1.00 79.04  ?  1033 GLU   C CA    1 
ATOM   6507 C C     . GLU   A 1 1033 ? 129.311 85.453  172.341 1.00 79.64  ?  1033 GLU   C C     1 
ATOM   6508 O O     . GLU   A 1 1033 ? 130.431 85.784  172.730 1.00 81.70  ?  1033 GLU   C O     1 
ATOM   6509 C CB    . GLU   A 1 1033 ? 128.093 84.003  173.995 1.00 83.77  ?  1033 GLU   C CB    1 
ATOM   6510 C CG    . GLU   A 1 1033 ? 127.488 82.658  174.338 1.00 89.21  ?  1033 GLU   C CG    1 
ATOM   6511 C CD    . GLU   A 1 1033 ? 128.474 81.746  174.994 1.00 92.35  ?  1033 GLU   C CD    1 
ATOM   6512 O OE1   . GLU   A 1 1033 ? 129.638 82.073  175.002 1.00 89.00  ?  1033 GLU   C OE1   1 
ATOM   6513 O OE2   . GLU   A 1 1033 ? 128.074 80.726  175.489 1.00 93.77  -1 1033 GLU   C OE2   1 
ATOM   6514 N N     . PRO   A 1 1034 ? 128.518 86.292  171.668 1.00 77.34  ?  1034 PRO   C N     1 
ATOM   6515 C CA    . PRO   A 1 1034 ? 128.831 87.663  171.274 1.00 77.19  ?  1034 PRO   C CA    1 
ATOM   6516 C C     . PRO   A 1 1034 ? 129.072 88.642  172.433 1.00 79.95  ?  1034 PRO   C C     1 
ATOM   6517 O O     . PRO   A 1 1034 ? 129.699 89.683  172.229 1.00 82.02  ?  1034 PRO   C O     1 
ATOM   6518 C CB    . PRO   A 1 1034 ? 127.584 88.060  170.470 1.00 76.13  ?  1034 PRO   C CB    1 
ATOM   6519 C CG    . PRO   A 1 1034 ? 126.489 87.129  170.947 1.00 79.91  ?  1034 PRO   C CG    1 
ATOM   6520 C CD    . PRO   A 1 1034 ? 127.189 85.833  171.255 1.00 76.53  ?  1034 PRO   C CD    1 
ATOM   6521 N N     . SER   A 1 1035 ? 128.564 88.324  173.633 1.00 81.26  ?  1035 SER   C N     1 
ATOM   6522 C CA    . SER   A 1 1035 ? 128.696 89.173  174.819 1.00 85.98  ?  1035 SER   C CA    1 
ATOM   6523 C C     . SER   A 1 1035 ? 128.281 88.389  176.066 1.00 92.72  ?  1035 SER   C C     1 
ATOM   6524 O O     . SER   A 1 1035 ? 127.329 87.607  176.019 1.00 88.11  ?  1035 SER   C O     1 
ATOM   6525 C CB    . SER   A 1 1035 ? 127.850 90.440  174.679 1.00 87.07  ?  1035 SER   C CB    1 
ATOM   6526 O OG    . SER   A 1 1035 ? 127.976 91.269  175.805 1.00 85.53  ?  1035 SER   C OG    1 
HETATM 6527 P PG    . ATP   B 2 .    ? 171.629 122.196 170.202 1.00 50.49  ?  1201 ATP   C PG    1 
HETATM 6528 O O1G   . ATP   B 2 .    ? 170.683 121.019 170.182 1.00 50.49  ?  1201 ATP   C O1G   1 
HETATM 6529 O O2G   . ATP   B 2 .    ? 171.150 123.396 169.423 1.00 50.49  -1 1201 ATP   C O2G   1 
HETATM 6530 O O3G   . ATP   B 2 .    ? 172.178 122.529 171.569 1.00 50.49  ?  1201 ATP   C O3G   1 
HETATM 6531 P PB    . ATP   B 2 .    ? 172.731 121.062 167.897 1.00 50.49  ?  1201 ATP   C PB    1 
HETATM 6532 O O1B   . ATP   B 2 .    ? 172.240 119.645 168.055 1.00 50.49  -1 1201 ATP   C O1B   1 
HETATM 6533 O O2B   . ATP   B 2 .    ? 171.940 122.042 167.068 1.00 50.49  ?  1201 ATP   C O2B   1 
HETATM 6534 O O3B   . ATP   B 2 .    ? 172.909 121.676 169.373 1.00 50.49  ?  1201 ATP   C O3B   1 
HETATM 6535 P PA    . ATP   B 2 .    ? 174.855 122.311 166.638 1.00 50.49  ?  1201 ATP   C PA    1 
HETATM 6536 O O1A   . ATP   B 2 .    ? 175.097 123.320 167.730 1.00 50.49  -1 1201 ATP   C O1A   1 
HETATM 6537 O O2A   . ATP   B 2 .    ? 174.000 122.658 165.447 1.00 50.49  ?  1201 ATP   C O2A   1 
HETATM 6538 O O3A   . ATP   B 2 .    ? 174.247 121.008 167.355 1.00 50.49  ?  1201 ATP   C O3A   1 
HETATM 6539 O "O5'" . ATP   B 2 .    ? 176.296 121.909 166.058 1.00 50.49  ?  1201 ATP   C "O5'" 1 
HETATM 6540 C "C5'" . ATP   B 2 .    ? 177.134 122.979 165.629 1.00 50.49  ?  1201 ATP   C "C5'" 1 
HETATM 6541 C "C4'" . ATP   B 2 .    ? 178.259 122.477 164.743 1.00 50.49  ?  1201 ATP   C "C4'" 1 
HETATM 6542 O "O4'" . ATP   B 2 .    ? 177.717 121.897 163.559 1.00 50.49  ?  1201 ATP   C "O4'" 1 
HETATM 6543 C "C3'" . ATP   B 2 .    ? 179.142 123.632 164.312 1.00 50.49  ?  1201 ATP   C "C3'" 1 
HETATM 6544 O "O3'" . ATP   B 2 .    ? 180.465 123.450 164.819 1.00 50.49  ?  1201 ATP   C "O3'" 1 
HETATM 6545 C "C2'" . ATP   B 2 .    ? 179.165 123.592 162.801 1.00 50.49  ?  1201 ATP   C "C2'" 1 
HETATM 6546 O "O2'" . ATP   B 2 .    ? 180.513 123.529 162.333 1.00 50.49  ?  1201 ATP   C "O2'" 1 
HETATM 6547 C "C1'" . ATP   B 2 .    ? 178.443 122.321 162.407 1.00 50.49  ?  1201 ATP   C "C1'" 1 
HETATM 6548 N N9    . ATP   B 2 .    ? 177.491 122.568 161.301 1.00 50.49  ?  1201 ATP   C N9    1 
HETATM 6549 C C8    . ATP   B 2 .    ? 176.226 122.121 161.273 1.00 50.49  ?  1201 ATP   C C8    1 
HETATM 6550 N N7    . ATP   B 2 .    ? 175.595 122.485 160.133 1.00 50.49  ?  1201 ATP   C N7    1 
HETATM 6551 C C5    . ATP   B 2 .    ? 176.475 123.182 159.406 1.00 50.49  ?  1201 ATP   C C5    1 
HETATM 6552 C C6    . ATP   B 2 .    ? 176.448 123.856 158.096 1.00 50.49  ?  1201 ATP   C C6    1 
HETATM 6553 N N6    . ATP   B 2 .    ? 175.328 123.845 157.340 1.00 50.49  ?  1201 ATP   C N6    1 
HETATM 6554 N N1    . ATP   B 2 .    ? 177.573 124.475 157.684 1.00 50.49  ?  1201 ATP   C N1    1 
HETATM 6555 C C2    . ATP   B 2 .    ? 178.684 124.483 158.439 1.00 50.49  ?  1201 ATP   C C2    1 
HETATM 6556 N N3    . ATP   B 2 .    ? 178.780 123.888 159.639 1.00 50.49  ?  1201 ATP   C N3    1 
HETATM 6557 C C4    . ATP   B 2 .    ? 177.726 123.230 160.170 1.00 50.49  ?  1201 ATP   C C4    1 
HETATM 6558 N N1    . A1BLP C 3 .    ? 168.765 107.545 169.011 1.00 46.51  ?  1202 A1BLP C N1    1 
HETATM 6559 N N3    . A1BLP C 3 .    ? 172.297 108.146 167.301 1.00 46.51  ?  1202 A1BLP C N3    1 
HETATM 6560 C C4    . A1BLP C 3 .    ? 168.834 105.546 166.894 1.00 46.51  ?  1202 A1BLP C C4    1 
HETATM 6561 C C5    . A1BLP C 3 .    ? 170.096 106.311 167.269 1.00 46.51  ?  1202 A1BLP C C5    1 
HETATM 6562 C C6    . A1BLP C 3 .    ? 169.996 106.803 168.728 1.00 46.51  ?  1202 A1BLP C C6    1 
HETATM 6563 C C7    . A1BLP C 3 .    ? 171.519 108.096 166.226 1.00 46.51  ?  1202 A1BLP C C7    1 
HETATM 6564 C C8    . A1BLP C 3 .    ? 173.851 109.544 166.230 1.00 46.51  ?  1202 A1BLP C C8    1 
HETATM 6565 C C10   . A1BLP C 3 .    ? 173.266 110.147 163.719 1.00 46.51  ?  1202 A1BLP C C10   1 
HETATM 6566 C C13   . A1BLP C 3 .    ? 171.893 108.775 165.082 1.00 46.51  ?  1202 A1BLP C C13   1 
HETATM 6567 C C15   . A1BLP C 3 .    ? 175.546 111.320 165.643 1.00 46.51  ?  1202 A1BLP C C15   1 
HETATM 6568 C C17   . A1BLP C 3 .    ? 177.576 111.561 166.909 1.00 46.51  ?  1202 A1BLP C C17   1 
HETATM 6569 C C20   . A1BLP C 3 .    ? 178.877 112.246 167.165 1.00 46.51  ?  1202 A1BLP C C20   1 
HETATM 6570 C C1    . A1BLP C 3 .    ? 168.728 108.834 168.321 1.00 46.51  ?  1202 A1BLP C C1    1 
HETATM 6571 O O1    . A1BLP C 3 .    ? 175.619 108.817 168.288 1.00 46.51  ?  1202 A1BLP C O1    1 
HETATM 6572 C C2    . A1BLP C 3 .    ? 167.592 106.736 168.666 1.00 46.51  ?  1202 A1BLP C C2    1 
HETATM 6573 N N2    . A1BLP C 3 .    ? 170.382 107.354 166.287 1.00 46.51  ?  1202 A1BLP C N2    1 
HETATM 6574 C C3    . A1BLP C 3 .    ? 167.597 106.380 167.201 1.00 46.51  ?  1202 A1BLP C C3    1 
HETATM 6575 N N4    . A1BLP C 3 .    ? 173.435 108.856 167.299 1.00 46.51  ?  1202 A1BLP C N4    1 
HETATM 6576 C C9    . A1BLP C 3 .    ? 173.072 109.512 165.075 1.00 46.51  ?  1202 A1BLP C C9    1 
HETATM 6577 C C11   . A1BLP C 3 .    ? 171.854 110.113 163.129 1.00 46.51  ?  1202 A1BLP C C11   1 
HETATM 6578 C C12   . A1BLP C 3 .    ? 171.212 108.864 163.740 1.00 46.51  ?  1202 A1BLP C C12   1 
HETATM 6579 C C14   . A1BLP C 3 .    ? 175.140 110.253 166.445 1.00 46.51  ?  1202 A1BLP C C14   1 
HETATM 6580 C C16   . A1BLP C 3 .    ? 176.750 111.964 165.874 1.00 46.51  ?  1202 A1BLP C C16   1 
HETATM 6581 C C18   . A1BLP C 3 .    ? 177.187 110.502 167.711 1.00 46.51  ?  1202 A1BLP C C18   1 
HETATM 6582 C C19   . A1BLP C 3 .    ? 175.985 109.859 167.483 1.00 46.51  ?  1202 A1BLP C C19   1 
HETATM 6583 F F1    . A1BLP C 3 .    ? 178.894 113.495 166.725 1.00 46.51  ?  1202 A1BLP C F1    1 
HETATM 6584 F F2    . A1BLP C 3 .    ? 179.900 111.634 166.589 1.00 46.51  ?  1202 A1BLP C F2    1 
HETATM 6585 F F3    . A1BLP C 3 .    ? 179.176 112.312 168.455 1.00 46.51  ?  1202 A1BLP C F3    1 
# 
