data_9MIC
# 
_entry.id   9MIC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MIC         pdb_00009mic 10.2210/pdb9mic/pdb 
WWPDB D_1000291033 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-05-28 ? 
2 'Structure model' 1 1 2025-06-04 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.page_first'              
2 2 'Structure model' '_citation.page_last'               
3 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
4 2 'Structure model' '_citation.title'                   
5 2 'Structure model' '_citation_author.identifier_ORCID' 
6 2 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MIC 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wilson@scripps.edu 
_pdbx_contact_author.name_first         Ian 
_pdbx_contact_author.name_last          Wilson 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6469-2419 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Agrawal, S.'  1 0000-0001-8549-9602 
'Wilson, I.A.' 2 0000-0002-6469-2419 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Science 
_citation.journal_id_ASTM           SCIEAS 
_citation.journal_id_CSD            0038 
_citation.journal_id_ISSN           1095-9203 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                eadv5572 
_citation.page_last                 eadv5572 
_citation.title                     'Precise targeting of HIV broadly neutralizing antibody precursors in humans.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/science.adv5572 
_citation.pdbx_database_id_PubMed   40373114 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Caniels, T.G.'           1  0000-0001-9580-157X 
primary 'Prabhakaran, M.'         2  0000-0002-1981-9054 
primary 'Ozorowski, G.'           3  0000-0002-9695-8138 
primary 'MacPhee, K.J.'           4  0009-0008-0993-4009 
primary 'Wu, W.'                  5  0009-0008-6015-9167 
primary 'van der Straten, K.'     6  0000-0001-6373-9302 
primary 'Agrawal, S.'             7  0000-0001-8549-9602 
primary 'Derking, R.'             8  ?                   
primary 'Reiss, E.I.M.M.'         9  0009-0006-4695-0628 
primary 'Millard, K.'             10 0000-0003-2247-3178 
primary 'Turroja, M.'             11 0000-0001-9640-0559 
primary 'Desrosiers, A.'          12 0009-0006-7576-4533 
primary 'Bethony, J.'             13 ?                   
primary 'Malkin, E.'              14 0000-0003-0943-5433 
primary 'Liesdek, M.H.'           15 ?                   
primary 'van der Veen, A.'        16 ?                   
primary 'Klouwens, M.'            17 0000-0002-3515-6748 
primary 'Snitselaar, J.L.'        18 0000-0002-2425-8335 
primary 'Bouhuijs, J.H.'          19 0000-0002-6074-8542 
primary 'Bronson, R.'             20 0009-0009-5513-3250 
primary 'Jean-Baptiste, J.'       21 0009-0008-5598-068X 
primary 'Gajjala, S.'             22 0000-0002-3828-1958 
primary 'Rikhtegaran Tehrani, Z.' 23 0000-0002-1127-1290 
primary 'Benner, A.'              24 0009-0001-8864-4091 
primary 'Ramaswami, M.'           25 0000-0002-4804-5676 
primary 'Duff, M.O.'              26 0009-0008-4279-0756 
primary 'Liu, Y.W.'               27 0000-0003-0524-3952 
primary 'Sato, A.H.'              28 0000-0001-8371-8007 
primary 'Kim, J.Y.'               29 0009-0002-1317-1223 
primary 'Baken, I.J.L.'           30 0009-0006-6818-1401 
primary 'Mendes Silva, C.'        31 0009-0007-3419-2513 
primary 'Bijl, T.P.L.'            32 ?                   
primary 'van Rijswijk, J.'        33 ?                   
primary 'Burger, J.A.'            34 ?                   
primary 'Cupo, A.'                35 0000-0001-7579-3525 
primary 'Yasmeen, A.'             36 0000-0002-2386-8991 
primary 'Phulera, S.'             37 0000-0002-1272-7712 
primary 'Lee, W.H.'               38 0000-0001-9445-6671 
primary 'Randall Jr., K.N.'       39 ?                   
primary 'Zhang, S.'               40 0000-0003-4586-0605 
primary 'Corcoran, M.M.'          41 0000-0002-2774-0936 
primary 'Regadas, I.'             42 ?                   
primary 'Sullivan, A.C.'          43 ?                   
primary 'Brown, D.M.'             44 0000-0003-4463-8316 
primary 'Bohl, J.A.'              45 ?                   
primary 'Greene, K.M.'            46 ?                   
primary 'Gao, H.'                 47 0000-0002-2468-8589 
primary 'Yates, N.L.'             48 0000-0003-2678-1311 
primary 'Sawant, S.'              49 0000-0002-1109-7907 
primary 'Prins, J.M.'             50 ?                   
primary 'Kootstra, N.A.'          51 0000-0001-9429-7754 
primary 'Kaminsky, S.M.'          52 0000-0003-1869-834X 
primary 'Barin, B.'               53 ?                   
primary 'Rahaman, F.'             54 0000-0003-4069-4580 
primary 'Meller, M.'              55 0009-0007-4884-9088 
primary 'Philiponis, V.'          56 0009-0009-3287-382X 
primary 'Laufer, D.S.'            57 0009-0009-6888-8281 
primary 'Lombardo, A.'            58 0000-0003-0182-133X 
primary 'Mwoga, L.'               59 0009-0006-7601-9201 
primary 'Shotorbani, S.'          60 0009-0005-0016-6697 
primary 'Holman, D.'              61 0009-0006-0595-7495 
primary 'Koup, R.A.'              62 0000-0002-3090-7282 
primary 'Klasse, P.J.'            63 0000-0001-8222-278X 
primary 'Karlsson Hedestam, G.B.' 64 0000-0001-7255-9047 
primary 'Tomaras, G.D.'           65 0000-0001-8076-1931 
primary 'van Gils, M.J.'          66 0000-0003-3422-8161 
primary 'Montefiori, D.C.'        67 0000-0003-0856-6319 
primary 'McDermott, A.B.'         68 0000-0003-0616-9117 
primary 'Hyrien, O.'              69 0000-0003-1909-2542 
primary 'Moore, J.P.'             70 0000-0002-9902-6096 
primary 'Wilson, I.A.'            71 0000-0002-6469-2419 
primary 'Ward, A.B.'              72 0000-0001-7153-3769 
primary 'Diemert, D.J.'           73 0000-0002-2789-0512 
primary 'de Bree, G.J.'           74 0000-0002-5852-5833 
primary 'Andrews, S.F.'           75 0000-0002-2583-1949 
primary 'Caskey, M.'              76 0000-0003-1727-8693 
primary 'Sanders, R.W.'           77 0000-0002-2324-8573 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '4D01 Fab heavy chain'                   24021.037 1   ? ? ? ? 
2 polymer     man '4D01 Fab light chain'                   22631.064 1   ? ? ? ? 
3 polymer     man 'eOD-GT8 engineered mutant of gp120'     19889.307 1   ? ? ? ? 
4 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   2   ? ? ? ? 
5 water       nat water                                    18.015    170 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINPTGGGVNYAHKFQGRVTMTRDTSISTAY
MELSRLTSDDTGVYYCARSPARELLPLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD
;
;QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINPTGGGVNYAHKFQGRVTMTRDTSISTAY
MELSRLTSDDTGVYYCARSPARELLPLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD
;
H ? 
2 'polypeptide(L)' no no 
;DIQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQIYETFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVT
EQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
;
;DIQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQIYETFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVT
EQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
;
L ? 
3 'polypeptide(L)' no no 
;DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDW
RDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCAS
TQLFASTWFASTGTGTKHHHHHH
;
;DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDW
RDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCAS
TQLFASTWFASTGTGTKHHHHHH
;
C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
5 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   VAL n 
1 3   GLN n 
1 4   LEU n 
1 5   VAL n 
1 6   GLN n 
1 7   SER n 
1 8   GLY n 
1 9   ALA n 
1 10  GLU n 
1 11  VAL n 
1 12  LYS n 
1 13  LYS n 
1 14  PRO n 
1 15  GLY n 
1 16  ALA n 
1 17  SER n 
1 18  VAL n 
1 19  LYS n 
1 20  VAL n 
1 21  SER n 
1 22  CYS n 
1 23  LYS n 
1 24  THR n 
1 25  SER n 
1 26  GLY n 
1 27  TYR n 
1 28  THR n 
1 29  PHE n 
1 30  THR n 
1 31  ASP n 
1 32  PHE n 
1 33  TYR n 
1 34  MET n 
1 35  HIS n 
1 36  TRP n 
1 37  MET n 
1 38  ARG n 
1 39  GLN n 
1 40  ALA n 
1 41  PRO n 
1 42  GLY n 
1 43  GLN n 
1 44  GLY n 
1 45  LEU n 
1 46  GLU n 
1 47  TRP n 
1 48  MET n 
1 49  GLY n 
1 50  TRP n 
1 51  ILE n 
1 52  ASN n 
1 53  PRO n 
1 54  THR n 
1 55  GLY n 
1 56  GLY n 
1 57  GLY n 
1 58  VAL n 
1 59  ASN n 
1 60  TYR n 
1 61  ALA n 
1 62  HIS n 
1 63  LYS n 
1 64  PHE n 
1 65  GLN n 
1 66  GLY n 
1 67  ARG n 
1 68  VAL n 
1 69  THR n 
1 70  MET n 
1 71  THR n 
1 72  ARG n 
1 73  ASP n 
1 74  THR n 
1 75  SER n 
1 76  ILE n 
1 77  SER n 
1 78  THR n 
1 79  ALA n 
1 80  TYR n 
1 81  MET n 
1 82  GLU n 
1 83  LEU n 
1 84  SER n 
1 85  ARG n 
1 86  LEU n 
1 87  THR n 
1 88  SER n 
1 89  ASP n 
1 90  ASP n 
1 91  THR n 
1 92  GLY n 
1 93  VAL n 
1 94  TYR n 
1 95  TYR n 
1 96  CYS n 
1 97  ALA n 
1 98  ARG n 
1 99  SER n 
1 100 PRO n 
1 101 ALA n 
1 102 ARG n 
1 103 GLU n 
1 104 LEU n 
1 105 LEU n 
1 106 PRO n 
1 107 LEU n 
1 108 ASP n 
1 109 TYR n 
1 110 TRP n 
1 111 GLY n 
1 112 GLN n 
1 113 GLY n 
1 114 THR n 
1 115 LEU n 
1 116 VAL n 
1 117 THR n 
1 118 VAL n 
1 119 SER n 
1 120 SER n 
1 121 ALA n 
1 122 SER n 
1 123 THR n 
1 124 LYS n 
1 125 GLY n 
1 126 PRO n 
1 127 SER n 
1 128 VAL n 
1 129 PHE n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 PRO n 
1 134 SER n 
1 135 SER n 
1 136 LYS n 
1 137 SER n 
1 138 THR n 
1 139 SER n 
1 140 GLY n 
1 141 GLY n 
1 142 THR n 
1 143 ALA n 
1 144 ALA n 
1 145 LEU n 
1 146 GLY n 
1 147 CYS n 
1 148 LEU n 
1 149 VAL n 
1 150 LYS n 
1 151 ASP n 
1 152 TYR n 
1 153 PHE n 
1 154 PRO n 
1 155 GLU n 
1 156 PRO n 
1 157 VAL n 
1 158 THR n 
1 159 VAL n 
1 160 SER n 
1 161 TRP n 
1 162 ASN n 
1 163 SER n 
1 164 GLY n 
1 165 ALA n 
1 166 LEU n 
1 167 THR n 
1 168 SER n 
1 169 GLY n 
1 170 VAL n 
1 171 HIS n 
1 172 THR n 
1 173 PHE n 
1 174 PRO n 
1 175 ALA n 
1 176 VAL n 
1 177 LEU n 
1 178 GLN n 
1 179 SER n 
1 180 SER n 
1 181 GLY n 
1 182 LEU n 
1 183 TYR n 
1 184 SER n 
1 185 LEU n 
1 186 SER n 
1 187 SER n 
1 188 VAL n 
1 189 VAL n 
1 190 THR n 
1 191 VAL n 
1 192 PRO n 
1 193 SER n 
1 194 SER n 
1 195 SER n 
1 196 LEU n 
1 197 GLY n 
1 198 THR n 
1 199 GLN n 
1 200 THR n 
1 201 TYR n 
1 202 ILE n 
1 203 CYS n 
1 204 ASN n 
1 205 VAL n 
1 206 ASN n 
1 207 HIS n 
1 208 LYS n 
1 209 PRO n 
1 210 SER n 
1 211 ASN n 
1 212 THR n 
1 213 LYS n 
1 214 VAL n 
1 215 ASP n 
1 216 LYS n 
1 217 ARG n 
1 218 VAL n 
1 219 GLU n 
1 220 PRO n 
1 221 LYS n 
1 222 SER n 
1 223 CYS n 
1 224 ASP n 
2 1   ASP n 
2 2   ILE n 
2 3   GLN n 
2 4   VAL n 
2 5   THR n 
2 6   GLN n 
2 7   SER n 
2 8   PRO n 
2 9   SER n 
2 10  SER n 
2 11  LEU n 
2 12  SER n 
2 13  ALA n 
2 14  SER n 
2 15  VAL n 
2 16  GLY n 
2 17  ASP n 
2 18  ARG n 
2 19  VAL n 
2 20  THR n 
2 21  ILE n 
2 22  THR n 
2 23  CYS n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  GLN n 
2 28  GLY n 
2 29  ILE n 
2 30  SER n 
2 31  ASN n 
2 32  TYR n 
2 33  LEU n 
2 34  ALA n 
2 35  TRP n 
2 36  TYR n 
2 37  GLN n 
2 38  GLN n 
2 39  LYS n 
2 40  PRO n 
2 41  GLY n 
2 42  LYS n 
2 43  VAL n 
2 44  PRO n 
2 45  LYS n 
2 46  LEU n 
2 47  LEU n 
2 48  ILE n 
2 49  TYR n 
2 50  GLY n 
2 51  ALA n 
2 52  SER n 
2 53  THR n 
2 54  LEU n 
2 55  GLN n 
2 56  SER n 
2 57  GLY n 
2 58  VAL n 
2 59  PRO n 
2 60  SER n 
2 61  ARG n 
2 62  PHE n 
2 63  SER n 
2 64  GLY n 
2 65  SER n 
2 66  GLY n 
2 67  SER n 
2 68  GLY n 
2 69  THR n 
2 70  ASP n 
2 71  PHE n 
2 72  THR n 
2 73  LEU n 
2 74  THR n 
2 75  ILE n 
2 76  SER n 
2 77  SER n 
2 78  LEU n 
2 79  GLN n 
2 80  PRO n 
2 81  GLU n 
2 82  ASP n 
2 83  PHE n 
2 84  ALA n 
2 85  THR n 
2 86  TYR n 
2 87  TYR n 
2 88  CYS n 
2 89  GLN n 
2 90  ILE n 
2 91  TYR n 
2 92  GLU n 
2 93  THR n 
2 94  PHE n 
2 95  GLY n 
2 96  GLN n 
2 97  GLY n 
2 98  THR n 
2 99  LYS n 
2 100 VAL n 
2 101 ASP n 
2 102 ILE n 
2 103 LYS n 
2 104 ARG n 
2 105 THR n 
2 106 VAL n 
2 107 ALA n 
2 108 ALA n 
2 109 PRO n 
2 110 SER n 
2 111 VAL n 
2 112 PHE n 
2 113 ILE n 
2 114 PHE n 
2 115 PRO n 
2 116 PRO n 
2 117 SER n 
2 118 ASP n 
2 119 GLU n 
2 120 GLN n 
2 121 LEU n 
2 122 LYS n 
2 123 SER n 
2 124 GLY n 
2 125 THR n 
2 126 ALA n 
2 127 SER n 
2 128 VAL n 
2 129 VAL n 
2 130 CYS n 
2 131 LEU n 
2 132 LEU n 
2 133 ASN n 
2 134 ASN n 
2 135 PHE n 
2 136 TYR n 
2 137 PRO n 
2 138 ARG n 
2 139 GLU n 
2 140 ALA n 
2 141 LYS n 
2 142 VAL n 
2 143 GLN n 
2 144 TRP n 
2 145 LYS n 
2 146 VAL n 
2 147 ASP n 
2 148 ASN n 
2 149 ALA n 
2 150 LEU n 
2 151 GLN n 
2 152 SER n 
2 153 GLY n 
2 154 ASN n 
2 155 SER n 
2 156 GLN n 
2 157 GLU n 
2 158 SER n 
2 159 VAL n 
2 160 THR n 
2 161 GLU n 
2 162 GLN n 
2 163 ASP n 
2 164 SER n 
2 165 LYS n 
2 166 ASP n 
2 167 SER n 
2 168 THR n 
2 169 TYR n 
2 170 SER n 
2 171 LEU n 
2 172 SER n 
2 173 SER n 
2 174 THR n 
2 175 LEU n 
2 176 THR n 
2 177 LEU n 
2 178 SER n 
2 179 LYS n 
2 180 ALA n 
2 181 ASP n 
2 182 TYR n 
2 183 GLU n 
2 184 LYS n 
2 185 HIS n 
2 186 LYS n 
2 187 VAL n 
2 188 TYR n 
2 189 ALA n 
2 190 CYS n 
2 191 GLU n 
2 192 VAL n 
2 193 THR n 
2 194 GLN n 
2 195 GLY n 
2 196 THR n 
2 197 THR n 
2 198 SER n 
2 199 VAL n 
2 200 THR n 
2 201 LYS n 
2 202 SER n 
2 203 PHE n 
2 204 ASN n 
2 205 ARG n 
2 206 GLY n 
2 207 GLU n 
2 208 CYS n 
3 1   ASP n 
3 2   THR n 
3 3   ILE n 
3 4   THR n 
3 5   LEU n 
3 6   PRO n 
3 7   CYS n 
3 8   ARG n 
3 9   PRO n 
3 10  ALA n 
3 11  PRO n 
3 12  PRO n 
3 13  PRO n 
3 14  HIS n 
3 15  CYS n 
3 16  SER n 
3 17  SER n 
3 18  ASN n 
3 19  ILE n 
3 20  THR n 
3 21  GLY n 
3 22  LEU n 
3 23  ILE n 
3 24  LEU n 
3 25  THR n 
3 26  ARG n 
3 27  GLN n 
3 28  GLY n 
3 29  GLY n 
3 30  TYR n 
3 31  SER n 
3 32  ASN n 
3 33  ALA n 
3 34  ASN n 
3 35  THR n 
3 36  VAL n 
3 37  ILE n 
3 38  PHE n 
3 39  ARG n 
3 40  PRO n 
3 41  SER n 
3 42  GLY n 
3 43  GLY n 
3 44  ASP n 
3 45  TRP n 
3 46  ARG n 
3 47  ASP n 
3 48  ILE n 
3 49  ALA n 
3 50  ARG n 
3 51  CYS n 
3 52  GLN n 
3 53  ILE n 
3 54  ALA n 
3 55  GLY n 
3 56  THR n 
3 57  VAL n 
3 58  VAL n 
3 59  SER n 
3 60  THR n 
3 61  GLN n 
3 62  LEU n 
3 63  PHE n 
3 64  LEU n 
3 65  ASN n 
3 66  GLY n 
3 67  SER n 
3 68  LEU n 
3 69  ALA n 
3 70  GLU n 
3 71  GLU n 
3 72  GLU n 
3 73  VAL n 
3 74  VAL n 
3 75  ILE n 
3 76  ARG n 
3 77  SER n 
3 78  GLU n 
3 79  ASP n 
3 80  TRP n 
3 81  ARG n 
3 82  ASP n 
3 83  ASN n 
3 84  ALA n 
3 85  LYS n 
3 86  SER n 
3 87  ILE n 
3 88  CYS n 
3 89  VAL n 
3 90  GLN n 
3 91  LEU n 
3 92  ALA n 
3 93  THR n 
3 94  SER n 
3 95  VAL n 
3 96  GLU n 
3 97  ILE n 
3 98  ALA n 
3 99  CYS n 
3 100 THR n 
3 101 GLY n 
3 102 ALA n 
3 103 GLY n 
3 104 HIS n 
3 105 CYS n 
3 106 ALA n 
3 107 ILE n 
3 108 SER n 
3 109 ARG n 
3 110 ALA n 
3 111 LYS n 
3 112 TRP n 
3 113 ALA n 
3 114 ASN n 
3 115 THR n 
3 116 LEU n 
3 117 LYS n 
3 118 GLN n 
3 119 ILE n 
3 120 ALA n 
3 121 SER n 
3 122 LYS n 
3 123 LEU n 
3 124 ARG n 
3 125 GLU n 
3 126 GLN n 
3 127 TYR n 
3 128 GLY n 
3 129 ALA n 
3 130 LYS n 
3 131 THR n 
3 132 ILE n 
3 133 ILE n 
3 134 PHE n 
3 135 LYS n 
3 136 PRO n 
3 137 SER n 
3 138 SER n 
3 139 GLY n 
3 140 GLY n 
3 141 ASP n 
3 142 PRO n 
3 143 GLU n 
3 144 PHE n 
3 145 VAL n 
3 146 ASN n 
3 147 HIS n 
3 148 SER n 
3 149 PHE n 
3 150 ASN n 
3 151 CYS n 
3 152 GLY n 
3 153 GLY n 
3 154 GLU n 
3 155 PHE n 
3 156 PHE n 
3 157 TYR n 
3 158 CYS n 
3 159 ALA n 
3 160 SER n 
3 161 THR n 
3 162 GLN n 
3 163 LEU n 
3 164 PHE n 
3 165 ALA n 
3 166 SER n 
3 167 THR n 
3 168 TRP n 
3 169 PHE n 
3 170 ALA n 
3 171 SER n 
3 172 THR n 
3 173 GLY n 
3 174 THR n 
3 175 GLY n 
3 176 THR n 
3 177 LYS n 
3 178 HIS n 
3 179 HIS n 
3 180 HIS n 
3 181 HIS n 
3 182 HIS n 
3 183 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 224 ? ? ? ? ? ? ? ? ? 'Homo sapiens'                   9606  ? ? ? ? ? ? ? ? 'Homo sapiens' 
9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 208 ? ? ? ? ? ? ? ? ? 'Homo sapiens'                   9606  ? ? ? ? ? ? ? ? 'Homo sapiens' 
9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 183 ? ? ? ? ? ? ? ? ? 'Human immunodeficiency virus 1' 11676 ? ? ? ? ? ? ? ? 'Homo sapiens' 
9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   1   1   GLN GLN H . n 
A 1 2   VAL 2   2   2   VAL VAL H . n 
A 1 3   GLN 3   3   3   GLN GLN H . n 
A 1 4   LEU 4   4   4   LEU LEU H . n 
A 1 5   VAL 5   5   5   VAL VAL H . n 
A 1 6   GLN 6   6   6   GLN GLN H . n 
A 1 7   SER 7   7   7   SER SER H . n 
A 1 8   GLY 8   8   8   GLY GLY H . n 
A 1 9   ALA 9   9   9   ALA ALA H . n 
A 1 10  GLU 10  10  10  GLU GLU H . n 
A 1 11  VAL 11  11  11  VAL VAL H . n 
A 1 12  LYS 12  12  12  LYS LYS H . n 
A 1 13  LYS 13  13  13  LYS LYS H . n 
A 1 14  PRO 14  14  14  PRO PRO H . n 
A 1 15  GLY 15  15  15  GLY GLY H . n 
A 1 16  ALA 16  16  16  ALA ALA H . n 
A 1 17  SER 17  17  17  SER SER H . n 
A 1 18  VAL 18  18  18  VAL VAL H . n 
A 1 19  LYS 19  19  19  LYS LYS H . n 
A 1 20  VAL 20  20  20  VAL VAL H . n 
A 1 21  SER 21  21  21  SER SER H . n 
A 1 22  CYS 22  22  22  CYS CYS H . n 
A 1 23  LYS 23  23  23  LYS LYS H . n 
A 1 24  THR 24  24  24  THR THR H . n 
A 1 25  SER 25  25  25  SER SER H . n 
A 1 26  GLY 26  26  26  GLY GLY H . n 
A 1 27  TYR 27  27  27  TYR TYR H . n 
A 1 28  THR 28  28  28  THR THR H . n 
A 1 29  PHE 29  29  29  PHE PHE H . n 
A 1 30  THR 30  30  30  THR THR H . n 
A 1 31  ASP 31  31  31  ASP ASP H . n 
A 1 32  PHE 32  32  32  PHE PHE H . n 
A 1 33  TYR 33  33  33  TYR TYR H . n 
A 1 34  MET 34  34  34  MET MET H . n 
A 1 35  HIS 35  35  35  HIS HIS H . n 
A 1 36  TRP 36  36  36  TRP TRP H . n 
A 1 37  MET 37  37  37  MET MET H . n 
A 1 38  ARG 38  38  38  ARG ARG H . n 
A 1 39  GLN 39  39  39  GLN GLN H . n 
A 1 40  ALA 40  40  40  ALA ALA H . n 
A 1 41  PRO 41  41  41  PRO PRO H . n 
A 1 42  GLY 42  42  42  GLY GLY H . n 
A 1 43  GLN 43  43  43  GLN GLN H . n 
A 1 44  GLY 44  44  44  GLY GLY H . n 
A 1 45  LEU 45  45  45  LEU LEU H . n 
A 1 46  GLU 46  46  46  GLU GLU H . n 
A 1 47  TRP 47  47  47  TRP TRP H . n 
A 1 48  MET 48  48  48  MET MET H . n 
A 1 49  GLY 49  49  49  GLY GLY H . n 
A 1 50  TRP 50  50  50  TRP TRP H . n 
A 1 51  ILE 51  51  51  ILE ILE H . n 
A 1 52  ASN 52  52  52  ASN ASN H . n 
A 1 53  PRO 53  52  52  PRO PRO H A n 
A 1 54  THR 54  53  53  THR THR H . n 
A 1 55  GLY 55  54  54  GLY GLY H . n 
A 1 56  GLY 56  55  55  GLY GLY H . n 
A 1 57  GLY 57  56  56  GLY GLY H . n 
A 1 58  VAL 58  57  57  VAL VAL H . n 
A 1 59  ASN 59  58  58  ASN ASN H . n 
A 1 60  TYR 60  59  59  TYR TYR H . n 
A 1 61  ALA 61  60  60  ALA ALA H . n 
A 1 62  HIS 62  61  61  HIS HIS H . n 
A 1 63  LYS 63  62  62  LYS LYS H . n 
A 1 64  PHE 64  63  63  PHE PHE H . n 
A 1 65  GLN 65  64  64  GLN GLN H . n 
A 1 66  GLY 66  65  65  GLY GLY H . n 
A 1 67  ARG 67  66  66  ARG ARG H . n 
A 1 68  VAL 68  67  67  VAL VAL H . n 
A 1 69  THR 69  68  68  THR THR H . n 
A 1 70  MET 70  69  69  MET MET H . n 
A 1 71  THR 71  70  70  THR THR H . n 
A 1 72  ARG 72  71  71  ARG ARG H . n 
A 1 73  ASP 73  72  72  ASP ASP H . n 
A 1 74  THR 74  73  73  THR THR H . n 
A 1 75  SER 75  74  74  SER SER H . n 
A 1 76  ILE 76  75  75  ILE ILE H . n 
A 1 77  SER 77  76  76  SER SER H . n 
A 1 78  THR 78  77  77  THR THR H . n 
A 1 79  ALA 79  78  78  ALA ALA H . n 
A 1 80  TYR 80  79  79  TYR TYR H . n 
A 1 81  MET 81  80  80  MET MET H . n 
A 1 82  GLU 82  81  81  GLU GLU H . n 
A 1 83  LEU 83  82  82  LEU LEU H . n 
A 1 84  SER 84  82  82  SER SER H A n 
A 1 85  ARG 85  82  82  ARG ARG H B n 
A 1 86  LEU 86  82  82  LEU LEU H C n 
A 1 87  THR 87  83  83  THR THR H . n 
A 1 88  SER 88  84  84  SER SER H . n 
A 1 89  ASP 89  85  85  ASP ASP H . n 
A 1 90  ASP 90  86  86  ASP ASP H . n 
A 1 91  THR 91  87  87  THR THR H . n 
A 1 92  GLY 92  88  88  GLY GLY H . n 
A 1 93  VAL 93  89  89  VAL VAL H . n 
A 1 94  TYR 94  90  90  TYR TYR H . n 
A 1 95  TYR 95  91  91  TYR TYR H . n 
A 1 96  CYS 96  92  92  CYS CYS H . n 
A 1 97  ALA 97  93  93  ALA ALA H . n 
A 1 98  ARG 98  94  94  ARG ARG H . n 
A 1 99  SER 99  95  95  SER SER H . n 
A 1 100 PRO 100 96  96  PRO PRO H . n 
A 1 101 ALA 101 97  97  ALA ALA H . n 
A 1 102 ARG 102 98  98  ARG ARG H . n 
A 1 103 GLU 103 99  99  GLU GLU H . n 
A 1 104 LEU 104 100 100 LEU LEU H . n 
A 1 105 LEU 105 100 100 LEU LEU H A n 
A 1 106 PRO 106 100 100 PRO PRO H B n 
A 1 107 LEU 107 100 100 LEU LEU H C n 
A 1 108 ASP 108 101 101 ASP ASP H . n 
A 1 109 TYR 109 102 102 TYR TYR H . n 
A 1 110 TRP 110 103 103 TRP TRP H . n 
A 1 111 GLY 111 104 104 GLY GLY H . n 
A 1 112 GLN 112 105 105 GLN GLN H . n 
A 1 113 GLY 113 106 106 GLY GLY H . n 
A 1 114 THR 114 107 107 THR THR H . n 
A 1 115 LEU 115 108 108 LEU LEU H . n 
A 1 116 VAL 116 109 109 VAL VAL H . n 
A 1 117 THR 117 110 110 THR THR H . n 
A 1 118 VAL 118 111 111 VAL VAL H . n 
A 1 119 SER 119 112 112 SER SER H . n 
A 1 120 SER 120 113 113 SER SER H . n 
A 1 121 ALA 121 114 114 ALA ALA H . n 
A 1 122 SER 122 115 115 SER SER H . n 
A 1 123 THR 123 116 116 THR THR H . n 
A 1 124 LYS 124 117 117 LYS LYS H . n 
A 1 125 GLY 125 118 118 GLY GLY H . n 
A 1 126 PRO 126 119 119 PRO PRO H . n 
A 1 127 SER 127 120 120 SER SER H . n 
A 1 128 VAL 128 121 121 VAL VAL H . n 
A 1 129 PHE 129 122 122 PHE PHE H . n 
A 1 130 PRO 130 123 123 PRO PRO H . n 
A 1 131 LEU 131 124 124 LEU LEU H . n 
A 1 132 ALA 132 125 125 ALA ALA H . n 
A 1 133 PRO 133 126 126 PRO PRO H . n 
A 1 134 SER 134 127 127 SER SER H . n 
A 1 135 SER 135 128 128 SER SER H . n 
A 1 136 LYS 136 129 129 LYS LYS H . n 
A 1 137 SER 137 130 130 SER SER H . n 
A 1 138 THR 138 131 131 THR THR H . n 
A 1 139 SER 139 132 132 SER SER H . n 
A 1 140 GLY 140 133 133 GLY GLY H . n 
A 1 141 GLY 141 134 134 GLY GLY H . n 
A 1 142 THR 142 135 135 THR THR H . n 
A 1 143 ALA 143 136 136 ALA ALA H . n 
A 1 144 ALA 144 137 137 ALA ALA H . n 
A 1 145 LEU 145 138 138 LEU LEU H . n 
A 1 146 GLY 146 139 139 GLY GLY H . n 
A 1 147 CYS 147 140 140 CYS CYS H . n 
A 1 148 LEU 148 141 141 LEU LEU H . n 
A 1 149 VAL 149 142 142 VAL VAL H . n 
A 1 150 LYS 150 143 143 LYS LYS H . n 
A 1 151 ASP 151 144 144 ASP ASP H . n 
A 1 152 TYR 152 145 145 TYR TYR H . n 
A 1 153 PHE 153 146 146 PHE PHE H . n 
A 1 154 PRO 154 147 147 PRO PRO H . n 
A 1 155 GLU 155 148 148 GLU GLU H . n 
A 1 156 PRO 156 149 149 PRO PRO H . n 
A 1 157 VAL 157 150 150 VAL VAL H . n 
A 1 158 THR 158 151 151 THR THR H . n 
A 1 159 VAL 159 152 152 VAL VAL H . n 
A 1 160 SER 160 153 153 SER SER H . n 
A 1 161 TRP 161 154 154 TRP TRP H . n 
A 1 162 ASN 162 155 155 ASN ASN H . n 
A 1 163 SER 163 156 156 SER SER H . n 
A 1 164 GLY 164 157 157 GLY GLY H . n 
A 1 165 ALA 165 158 158 ALA ALA H . n 
A 1 166 LEU 166 159 159 LEU LEU H . n 
A 1 167 THR 167 160 160 THR THR H . n 
A 1 168 SER 168 161 161 SER SER H . n 
A 1 169 GLY 169 162 162 GLY GLY H . n 
A 1 170 VAL 170 163 163 VAL VAL H . n 
A 1 171 HIS 171 164 164 HIS HIS H . n 
A 1 172 THR 172 165 165 THR THR H . n 
A 1 173 PHE 173 166 166 PHE PHE H . n 
A 1 174 PRO 174 167 167 PRO PRO H . n 
A 1 175 ALA 175 168 168 ALA ALA H . n 
A 1 176 VAL 176 169 169 VAL VAL H . n 
A 1 177 LEU 177 170 170 LEU LEU H . n 
A 1 178 GLN 178 171 171 GLN GLN H . n 
A 1 179 SER 179 172 172 SER SER H . n 
A 1 180 SER 180 173 173 SER SER H . n 
A 1 181 GLY 181 174 174 GLY GLY H . n 
A 1 182 LEU 182 175 175 LEU LEU H . n 
A 1 183 TYR 183 176 176 TYR TYR H . n 
A 1 184 SER 184 177 177 SER SER H . n 
A 1 185 LEU 185 178 178 LEU LEU H . n 
A 1 186 SER 186 179 179 SER SER H . n 
A 1 187 SER 187 180 180 SER SER H . n 
A 1 188 VAL 188 181 181 VAL VAL H . n 
A 1 189 VAL 189 182 182 VAL VAL H . n 
A 1 190 THR 190 183 183 THR THR H . n 
A 1 191 VAL 191 184 184 VAL VAL H . n 
A 1 192 PRO 192 185 185 PRO PRO H . n 
A 1 193 SER 193 186 186 SER SER H . n 
A 1 194 SER 194 187 187 SER SER H . n 
A 1 195 SER 195 188 188 SER SER H . n 
A 1 196 LEU 196 189 189 LEU LEU H . n 
A 1 197 GLY 197 190 190 GLY GLY H . n 
A 1 198 THR 198 191 191 THR THR H . n 
A 1 199 GLN 199 192 192 GLN GLN H . n 
A 1 200 THR 200 193 193 THR THR H . n 
A 1 201 TYR 201 194 194 TYR TYR H . n 
A 1 202 ILE 202 195 195 ILE ILE H . n 
A 1 203 CYS 203 196 196 CYS CYS H . n 
A 1 204 ASN 204 197 197 ASN ASN H . n 
A 1 205 VAL 205 198 198 VAL VAL H . n 
A 1 206 ASN 206 199 199 ASN ASN H . n 
A 1 207 HIS 207 200 200 HIS HIS H . n 
A 1 208 LYS 208 201 201 LYS LYS H . n 
A 1 209 PRO 209 202 202 PRO PRO H . n 
A 1 210 SER 210 203 203 SER SER H . n 
A 1 211 ASN 211 204 204 ASN ASN H . n 
A 1 212 THR 212 205 205 THR THR H . n 
A 1 213 LYS 213 206 206 LYS LYS H . n 
A 1 214 VAL 214 207 207 VAL VAL H . n 
A 1 215 ASP 215 208 208 ASP ASP H . n 
A 1 216 LYS 216 209 209 LYS LYS H . n 
A 1 217 ARG 217 210 210 ARG ARG H . n 
A 1 218 VAL 218 211 211 VAL VAL H . n 
A 1 219 GLU 219 212 212 GLU GLU H . n 
A 1 220 PRO 220 213 213 PRO PRO H . n 
A 1 221 LYS 221 214 214 LYS LYS H . n 
A 1 222 SER 222 215 ?   ?   ?   H . n 
A 1 223 CYS 223 216 ?   ?   ?   H . n 
A 1 224 ASP 224 217 ?   ?   ?   H . n 
B 2 1   ASP 1   1   ?   ?   ?   L . n 
B 2 2   ILE 2   2   2   ILE ILE L . n 
B 2 3   GLN 3   3   3   GLN GLN L . n 
B 2 4   VAL 4   4   4   VAL VAL L . n 
B 2 5   THR 5   5   5   THR THR L . n 
B 2 6   GLN 6   6   6   GLN GLN L . n 
B 2 7   SER 7   7   7   SER SER L . n 
B 2 8   PRO 8   8   8   PRO PRO L . n 
B 2 9   SER 9   9   9   SER SER L . n 
B 2 10  SER 10  10  10  SER SER L . n 
B 2 11  LEU 11  11  11  LEU LEU L . n 
B 2 12  SER 12  12  12  SER SER L . n 
B 2 13  ALA 13  13  13  ALA ALA L . n 
B 2 14  SER 14  14  14  SER SER L . n 
B 2 15  VAL 15  15  15  VAL VAL L . n 
B 2 16  GLY 16  16  16  GLY GLY L . n 
B 2 17  ASP 17  17  17  ASP ASP L . n 
B 2 18  ARG 18  18  18  ARG ARG L . n 
B 2 19  VAL 19  19  19  VAL VAL L . n 
B 2 20  THR 20  20  20  THR THR L . n 
B 2 21  ILE 21  21  21  ILE ILE L . n 
B 2 22  THR 22  22  22  THR THR L . n 
B 2 23  CYS 23  23  23  CYS CYS L . n 
B 2 24  ARG 24  24  24  ARG ARG L . n 
B 2 25  ALA 25  25  25  ALA ALA L . n 
B 2 26  SER 26  26  26  SER SER L . n 
B 2 27  GLN 27  27  27  GLN GLN L . n 
B 2 28  GLY 28  28  28  GLY GLY L . n 
B 2 29  ILE 29  29  29  ILE ILE L . n 
B 2 30  SER 30  30  30  SER SER L . n 
B 2 31  ASN 31  31  31  ASN ASN L . n 
B 2 32  TYR 32  32  32  TYR TYR L . n 
B 2 33  LEU 33  33  33  LEU LEU L . n 
B 2 34  ALA 34  34  34  ALA ALA L . n 
B 2 35  TRP 35  35  35  TRP TRP L . n 
B 2 36  TYR 36  36  36  TYR TYR L . n 
B 2 37  GLN 37  37  37  GLN GLN L . n 
B 2 38  GLN 38  38  38  GLN GLN L . n 
B 2 39  LYS 39  39  39  LYS LYS L . n 
B 2 40  PRO 40  40  40  PRO PRO L . n 
B 2 41  GLY 41  41  41  GLY GLY L . n 
B 2 42  LYS 42  42  42  LYS LYS L . n 
B 2 43  VAL 43  43  43  VAL VAL L . n 
B 2 44  PRO 44  44  44  PRO PRO L . n 
B 2 45  LYS 45  45  45  LYS LYS L . n 
B 2 46  LEU 46  46  46  LEU LEU L . n 
B 2 47  LEU 47  47  47  LEU LEU L . n 
B 2 48  ILE 48  48  48  ILE ILE L . n 
B 2 49  TYR 49  49  49  TYR TYR L . n 
B 2 50  GLY 50  50  50  GLY GLY L . n 
B 2 51  ALA 51  51  51  ALA ALA L . n 
B 2 52  SER 52  52  52  SER SER L . n 
B 2 53  THR 53  53  53  THR THR L . n 
B 2 54  LEU 54  54  54  LEU LEU L . n 
B 2 55  GLN 55  55  55  GLN GLN L . n 
B 2 56  SER 56  56  56  SER SER L . n 
B 2 57  GLY 57  57  57  GLY GLY L . n 
B 2 58  VAL 58  58  58  VAL VAL L . n 
B 2 59  PRO 59  59  59  PRO PRO L . n 
B 2 60  SER 60  60  60  SER SER L . n 
B 2 61  ARG 61  61  61  ARG ARG L . n 
B 2 62  PHE 62  62  62  PHE PHE L . n 
B 2 63  SER 63  63  63  SER SER L . n 
B 2 64  GLY 64  64  64  GLY GLY L . n 
B 2 65  SER 65  65  65  SER SER L . n 
B 2 66  GLY 66  66  66  GLY GLY L . n 
B 2 67  SER 67  67  67  SER SER L . n 
B 2 68  GLY 68  68  68  GLY GLY L . n 
B 2 69  THR 69  69  69  THR THR L . n 
B 2 70  ASP 70  70  70  ASP ASP L . n 
B 2 71  PHE 71  71  71  PHE PHE L . n 
B 2 72  THR 72  72  72  THR THR L . n 
B 2 73  LEU 73  73  73  LEU LEU L . n 
B 2 74  THR 74  74  74  THR THR L . n 
B 2 75  ILE 75  75  75  ILE ILE L . n 
B 2 76  SER 76  76  76  SER SER L . n 
B 2 77  SER 77  77  77  SER SER L . n 
B 2 78  LEU 78  78  78  LEU LEU L . n 
B 2 79  GLN 79  79  79  GLN GLN L . n 
B 2 80  PRO 80  80  80  PRO PRO L . n 
B 2 81  GLU 81  81  81  GLU GLU L . n 
B 2 82  ASP 82  82  82  ASP ASP L . n 
B 2 83  PHE 83  83  83  PHE PHE L . n 
B 2 84  ALA 84  84  84  ALA ALA L . n 
B 2 85  THR 85  85  85  THR THR L . n 
B 2 86  TYR 86  86  86  TYR TYR L . n 
B 2 87  TYR 87  87  87  TYR TYR L . n 
B 2 88  CYS 88  88  88  CYS CYS L . n 
B 2 89  GLN 89  89  89  GLN GLN L . n 
B 2 90  ILE 90  90  90  ILE ILE L . n 
B 2 91  TYR 91  91  91  TYR TYR L . n 
B 2 92  GLU 92  96  96  GLU GLU L . n 
B 2 93  THR 93  97  97  THR THR L . n 
B 2 94  PHE 94  98  98  PHE PHE L . n 
B 2 95  GLY 95  99  99  GLY GLY L . n 
B 2 96  GLN 96  100 100 GLN GLN L . n 
B 2 97  GLY 97  101 101 GLY GLY L . n 
B 2 98  THR 98  102 102 THR THR L . n 
B 2 99  LYS 99  103 103 LYS LYS L . n 
B 2 100 VAL 100 104 104 VAL VAL L . n 
B 2 101 ASP 101 105 105 ASP ASP L . n 
B 2 102 ILE 102 106 106 ILE ILE L . n 
B 2 103 LYS 103 107 107 LYS LYS L . n 
B 2 104 ARG 104 108 108 ARG ARG L . n 
B 2 105 THR 105 109 109 THR THR L . n 
B 2 106 VAL 106 110 110 VAL VAL L . n 
B 2 107 ALA 107 111 111 ALA ALA L . n 
B 2 108 ALA 108 112 112 ALA ALA L . n 
B 2 109 PRO 109 113 113 PRO PRO L . n 
B 2 110 SER 110 114 114 SER SER L . n 
B 2 111 VAL 111 115 115 VAL VAL L . n 
B 2 112 PHE 112 116 116 PHE PHE L . n 
B 2 113 ILE 113 117 117 ILE ILE L . n 
B 2 114 PHE 114 118 118 PHE PHE L . n 
B 2 115 PRO 115 119 119 PRO PRO L . n 
B 2 116 PRO 116 120 120 PRO PRO L . n 
B 2 117 SER 117 121 121 SER SER L . n 
B 2 118 ASP 118 122 122 ASP ASP L . n 
B 2 119 GLU 119 123 123 GLU GLU L . n 
B 2 120 GLN 120 124 124 GLN GLN L . n 
B 2 121 LEU 121 125 125 LEU LEU L . n 
B 2 122 LYS 122 126 126 LYS LYS L . n 
B 2 123 SER 123 127 127 SER SER L . n 
B 2 124 GLY 124 128 128 GLY GLY L . n 
B 2 125 THR 125 129 129 THR THR L . n 
B 2 126 ALA 126 130 130 ALA ALA L . n 
B 2 127 SER 127 131 131 SER SER L . n 
B 2 128 VAL 128 132 132 VAL VAL L . n 
B 2 129 VAL 129 133 133 VAL VAL L . n 
B 2 130 CYS 130 134 134 CYS CYS L . n 
B 2 131 LEU 131 135 135 LEU LEU L . n 
B 2 132 LEU 132 136 136 LEU LEU L . n 
B 2 133 ASN 133 137 137 ASN ASN L . n 
B 2 134 ASN 134 138 138 ASN ASN L . n 
B 2 135 PHE 135 139 139 PHE PHE L . n 
B 2 136 TYR 136 140 140 TYR TYR L . n 
B 2 137 PRO 137 141 141 PRO PRO L . n 
B 2 138 ARG 138 142 142 ARG ARG L . n 
B 2 139 GLU 139 143 143 GLU GLU L . n 
B 2 140 ALA 140 144 144 ALA ALA L . n 
B 2 141 LYS 141 145 145 LYS LYS L . n 
B 2 142 VAL 142 146 146 VAL VAL L . n 
B 2 143 GLN 143 147 147 GLN GLN L . n 
B 2 144 TRP 144 148 148 TRP TRP L . n 
B 2 145 LYS 145 149 149 LYS LYS L . n 
B 2 146 VAL 146 150 150 VAL VAL L . n 
B 2 147 ASP 147 151 151 ASP ASP L . n 
B 2 148 ASN 148 152 152 ASN ASN L . n 
B 2 149 ALA 149 153 153 ALA ALA L . n 
B 2 150 LEU 150 154 154 LEU LEU L . n 
B 2 151 GLN 151 155 155 GLN GLN L . n 
B 2 152 SER 152 156 156 SER SER L . n 
B 2 153 GLY 153 157 157 GLY GLY L . n 
B 2 154 ASN 154 158 158 ASN ASN L . n 
B 2 155 SER 155 159 159 SER SER L . n 
B 2 156 GLN 156 160 160 GLN GLN L . n 
B 2 157 GLU 157 161 161 GLU GLU L . n 
B 2 158 SER 158 162 162 SER SER L . n 
B 2 159 VAL 159 163 163 VAL VAL L . n 
B 2 160 THR 160 164 164 THR THR L . n 
B 2 161 GLU 161 165 165 GLU GLU L . n 
B 2 162 GLN 162 166 166 GLN GLN L . n 
B 2 163 ASP 163 167 167 ASP ASP L . n 
B 2 164 SER 164 168 168 SER SER L . n 
B 2 165 LYS 165 169 169 LYS LYS L . n 
B 2 166 ASP 166 170 170 ASP ASP L . n 
B 2 167 SER 167 171 171 SER SER L . n 
B 2 168 THR 168 172 172 THR THR L . n 
B 2 169 TYR 169 173 173 TYR TYR L . n 
B 2 170 SER 170 174 174 SER SER L . n 
B 2 171 LEU 171 175 175 LEU LEU L . n 
B 2 172 SER 172 176 176 SER SER L . n 
B 2 173 SER 173 177 177 SER SER L . n 
B 2 174 THR 174 178 178 THR THR L . n 
B 2 175 LEU 175 179 179 LEU LEU L . n 
B 2 176 THR 176 180 180 THR THR L . n 
B 2 177 LEU 177 181 181 LEU LEU L . n 
B 2 178 SER 178 182 182 SER SER L . n 
B 2 179 LYS 179 183 183 LYS LYS L . n 
B 2 180 ALA 180 184 184 ALA ALA L . n 
B 2 181 ASP 181 185 185 ASP ASP L . n 
B 2 182 TYR 182 186 186 TYR TYR L . n 
B 2 183 GLU 183 187 187 GLU GLU L . n 
B 2 184 LYS 184 188 188 LYS LYS L . n 
B 2 185 HIS 185 189 189 HIS HIS L . n 
B 2 186 LYS 186 190 190 LYS LYS L . n 
B 2 187 VAL 187 191 191 VAL VAL L . n 
B 2 188 TYR 188 192 192 TYR TYR L . n 
B 2 189 ALA 189 193 193 ALA ALA L . n 
B 2 190 CYS 190 194 194 CYS CYS L . n 
B 2 191 GLU 191 195 195 GLU GLU L . n 
B 2 192 VAL 192 196 196 VAL VAL L . n 
B 2 193 THR 193 197 197 THR THR L . n 
B 2 194 GLN 194 198 198 GLN GLN L . n 
B 2 195 GLY 195 199 199 GLY GLY L . n 
B 2 196 THR 196 200 200 THR THR L . n 
B 2 197 THR 197 201 201 THR THR L . n 
B 2 198 SER 198 202 202 SER SER L . n 
B 2 199 VAL 199 203 203 VAL VAL L . n 
B 2 200 THR 200 204 204 THR THR L . n 
B 2 201 LYS 201 205 205 LYS LYS L . n 
B 2 202 SER 202 206 206 SER SER L . n 
B 2 203 PHE 203 207 207 PHE PHE L . n 
B 2 204 ASN 204 208 208 ASN ASN L . n 
B 2 205 ARG 205 209 209 ARG ARG L . n 
B 2 206 GLY 206 210 210 GLY GLY L . n 
B 2 207 GLU 207 211 211 GLU GLU L . n 
B 2 208 CYS 208 212 212 CYS CYS L . n 
C 3 1   ASP 1   1   1   ASP ASP C . n 
C 3 2   THR 2   2   2   THR THR C . n 
C 3 3   ILE 3   3   3   ILE ILE C . n 
C 3 4   THR 4   4   4   THR THR C . n 
C 3 5   LEU 5   5   5   LEU LEU C . n 
C 3 6   PRO 6   6   6   PRO PRO C . n 
C 3 7   CYS 7   7   7   CYS CYS C . n 
C 3 8   ARG 8   8   8   ARG ARG C . n 
C 3 9   PRO 9   9   9   PRO PRO C . n 
C 3 10  ALA 10  10  10  ALA ALA C . n 
C 3 11  PRO 11  11  11  PRO PRO C . n 
C 3 12  PRO 12  12  12  PRO PRO C . n 
C 3 13  PRO 13  13  13  PRO PRO C . n 
C 3 14  HIS 14  14  14  HIS HIS C . n 
C 3 15  CYS 15  15  15  CYS CYS C . n 
C 3 16  SER 16  16  16  SER SER C . n 
C 3 17  SER 17  17  17  SER SER C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  ILE 19  19  19  ILE ILE C . n 
C 3 20  THR 20  20  20  THR THR C . n 
C 3 21  GLY 21  21  21  GLY GLY C . n 
C 3 22  LEU 22  22  22  LEU LEU C . n 
C 3 23  ILE 23  23  23  ILE ILE C . n 
C 3 24  LEU 24  24  24  LEU LEU C . n 
C 3 25  THR 25  25  25  THR THR C . n 
C 3 26  ARG 26  26  26  ARG ARG C . n 
C 3 27  GLN 27  27  27  GLN GLN C . n 
C 3 28  GLY 28  28  28  GLY GLY C . n 
C 3 29  GLY 29  29  29  GLY GLY C . n 
C 3 30  TYR 30  30  30  TYR TYR C . n 
C 3 31  SER 31  31  31  SER SER C . n 
C 3 32  ASN 32  32  32  ASN ASN C . n 
C 3 33  ALA 33  33  33  ALA ALA C . n 
C 3 34  ASN 34  34  34  ASN ASN C . n 
C 3 35  THR 35  35  35  THR THR C . n 
C 3 36  VAL 36  36  36  VAL VAL C . n 
C 3 37  ILE 37  37  37  ILE ILE C . n 
C 3 38  PHE 38  38  38  PHE PHE C . n 
C 3 39  ARG 39  39  39  ARG ARG C . n 
C 3 40  PRO 40  40  40  PRO PRO C . n 
C 3 41  SER 41  41  41  SER SER C . n 
C 3 42  GLY 42  42  42  GLY GLY C . n 
C 3 43  GLY 43  43  43  GLY GLY C . n 
C 3 44  ASP 44  44  44  ASP ASP C . n 
C 3 45  TRP 45  45  45  TRP TRP C . n 
C 3 46  ARG 46  46  46  ARG ARG C . n 
C 3 47  ASP 47  47  47  ASP ASP C . n 
C 3 48  ILE 48  48  48  ILE ILE C . n 
C 3 49  ALA 49  49  49  ALA ALA C . n 
C 3 50  ARG 50  50  50  ARG ARG C . n 
C 3 51  CYS 51  51  51  CYS CYS C . n 
C 3 52  GLN 52  52  52  GLN GLN C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  ALA 54  54  54  ALA ALA C . n 
C 3 55  GLY 55  55  55  GLY GLY C . n 
C 3 56  THR 56  56  56  THR THR C . n 
C 3 57  VAL 57  57  57  VAL VAL C . n 
C 3 58  VAL 58  58  58  VAL VAL C . n 
C 3 59  SER 59  59  59  SER SER C . n 
C 3 60  THR 60  60  60  THR THR C . n 
C 3 61  GLN 61  61  61  GLN GLN C . n 
C 3 62  LEU 62  62  62  LEU LEU C . n 
C 3 63  PHE 63  63  63  PHE PHE C . n 
C 3 64  LEU 64  64  64  LEU LEU C . n 
C 3 65  ASN 65  65  65  ASN ASN C . n 
C 3 66  GLY 66  66  66  GLY GLY C . n 
C 3 67  SER 67  67  67  SER SER C . n 
C 3 68  LEU 68  68  68  LEU LEU C . n 
C 3 69  ALA 69  69  69  ALA ALA C . n 
C 3 70  GLU 70  70  70  GLU GLU C . n 
C 3 71  GLU 71  71  71  GLU GLU C . n 
C 3 72  GLU 72  72  72  GLU GLU C . n 
C 3 73  VAL 73  73  73  VAL VAL C . n 
C 3 74  VAL 74  74  74  VAL VAL C . n 
C 3 75  ILE 75  75  75  ILE ILE C . n 
C 3 76  ARG 76  76  76  ARG ARG C . n 
C 3 77  SER 77  77  77  SER SER C . n 
C 3 78  GLU 78  78  78  GLU GLU C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  TRP 80  80  80  TRP TRP C . n 
C 3 81  ARG 81  81  81  ARG ARG C . n 
C 3 82  ASP 82  82  82  ASP ASP C . n 
C 3 83  ASN 83  83  83  ASN ASN C . n 
C 3 84  ALA 84  84  84  ALA ALA C . n 
C 3 85  LYS 85  85  85  LYS LYS C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  ILE 87  87  87  ILE ILE C . n 
C 3 88  CYS 88  88  88  CYS CYS C . n 
C 3 89  VAL 89  89  89  VAL VAL C . n 
C 3 90  GLN 90  90  90  GLN GLN C . n 
C 3 91  LEU 91  91  91  LEU LEU C . n 
C 3 92  ALA 92  92  92  ALA ALA C . n 
C 3 93  THR 93  93  93  THR THR C . n 
C 3 94  SER 94  94  94  SER SER C . n 
C 3 95  VAL 95  95  95  VAL VAL C . n 
C 3 96  GLU 96  96  96  GLU GLU C . n 
C 3 97  ILE 97  97  97  ILE ILE C . n 
C 3 98  ALA 98  98  98  ALA ALA C . n 
C 3 99  CYS 99  99  99  CYS CYS C . n 
C 3 100 THR 100 100 100 THR THR C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 ALA 102 102 102 ALA ALA C . n 
C 3 103 GLY 103 103 103 GLY GLY C . n 
C 3 104 HIS 104 104 104 HIS HIS C . n 
C 3 105 CYS 105 105 105 CYS CYS C . n 
C 3 106 ALA 106 106 106 ALA ALA C . n 
C 3 107 ILE 107 107 107 ILE ILE C . n 
C 3 108 SER 108 108 108 SER SER C . n 
C 3 109 ARG 109 109 109 ARG ARG C . n 
C 3 110 ALA 110 110 110 ALA ALA C . n 
C 3 111 LYS 111 111 111 LYS LYS C . n 
C 3 112 TRP 112 112 112 TRP TRP C . n 
C 3 113 ALA 113 113 113 ALA ALA C . n 
C 3 114 ASN 114 114 114 ASN ASN C . n 
C 3 115 THR 115 115 115 THR THR C . n 
C 3 116 LEU 116 116 116 LEU LEU C . n 
C 3 117 LYS 117 117 117 LYS LYS C . n 
C 3 118 GLN 118 118 118 GLN GLN C . n 
C 3 119 ILE 119 119 119 ILE ILE C . n 
C 3 120 ALA 120 120 120 ALA ALA C . n 
C 3 121 SER 121 121 121 SER SER C . n 
C 3 122 LYS 122 122 122 LYS LYS C . n 
C 3 123 LEU 123 123 123 LEU LEU C . n 
C 3 124 ARG 124 124 124 ARG ARG C . n 
C 3 125 GLU 125 125 125 GLU GLU C . n 
C 3 126 GLN 126 126 126 GLN GLN C . n 
C 3 127 TYR 127 127 127 TYR TYR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 ALA 129 129 129 ALA ALA C . n 
C 3 130 LYS 130 130 130 LYS LYS C . n 
C 3 131 THR 131 131 131 THR THR C . n 
C 3 132 ILE 132 132 132 ILE ILE C . n 
C 3 133 ILE 133 133 133 ILE ILE C . n 
C 3 134 PHE 134 134 134 PHE PHE C . n 
C 3 135 LYS 135 135 135 LYS LYS C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 SER 137 137 137 SER SER C . n 
C 3 138 SER 138 138 138 SER SER C . n 
C 3 139 GLY 139 139 139 GLY GLY C . n 
C 3 140 GLY 140 140 140 GLY GLY C . n 
C 3 141 ASP 141 141 141 ASP ASP C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 GLU 143 143 143 GLU GLU C . n 
C 3 144 PHE 144 144 144 PHE PHE C . n 
C 3 145 VAL 145 145 145 VAL VAL C . n 
C 3 146 ASN 146 146 146 ASN ASN C . n 
C 3 147 HIS 147 147 147 HIS HIS C . n 
C 3 148 SER 148 148 148 SER SER C . n 
C 3 149 PHE 149 149 149 PHE PHE C . n 
C 3 150 ASN 150 150 150 ASN ASN C . n 
C 3 151 CYS 151 151 151 CYS CYS C . n 
C 3 152 GLY 152 152 152 GLY GLY C . n 
C 3 153 GLY 153 153 153 GLY GLY C . n 
C 3 154 GLU 154 154 154 GLU GLU C . n 
C 3 155 PHE 155 155 155 PHE PHE C . n 
C 3 156 PHE 156 156 156 PHE PHE C . n 
C 3 157 TYR 157 157 157 TYR TYR C . n 
C 3 158 CYS 158 158 158 CYS CYS C . n 
C 3 159 ALA 159 159 159 ALA ALA C . n 
C 3 160 SER 160 160 160 SER SER C . n 
C 3 161 THR 161 161 161 THR THR C . n 
C 3 162 GLN 162 162 162 GLN GLN C . n 
C 3 163 LEU 163 163 163 LEU LEU C . n 
C 3 164 PHE 164 164 164 PHE PHE C . n 
C 3 165 ALA 165 165 165 ALA ALA C . n 
C 3 166 SER 166 166 166 SER SER C . n 
C 3 167 THR 167 167 167 THR THR C . n 
C 3 168 TRP 168 168 168 TRP TRP C . n 
C 3 169 PHE 169 169 169 PHE PHE C . n 
C 3 170 ALA 170 170 ?   ?   ?   C . n 
C 3 171 SER 171 171 ?   ?   ?   C . n 
C 3 172 THR 172 172 ?   ?   ?   C . n 
C 3 173 GLY 173 173 ?   ?   ?   C . n 
C 3 174 THR 174 174 ?   ?   ?   C . n 
C 3 175 GLY 175 175 ?   ?   ?   C . n 
C 3 176 THR 176 176 ?   ?   ?   C . n 
C 3 177 LYS 177 177 ?   ?   ?   C . n 
C 3 178 HIS 178 178 ?   ?   ?   C . n 
C 3 179 HIS 179 179 ?   ?   ?   C . n 
C 3 180 HIS 180 180 ?   ?   ?   C . n 
C 3 181 HIS 181 181 ?   ?   ?   C . n 
C 3 182 HIS 182 182 ?   ?   ?   C . n 
C 3 183 HIS 183 183 ?   ?   ?   C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 NAG 1  201 1   NAG NAG C . 
E 4 NAG 1  202 2   NAG NAG C . 
F 5 HOH 1  301 143 HOH HOH H . 
F 5 HOH 2  302 82  HOH HOH H . 
F 5 HOH 3  303 167 HOH HOH H . 
F 5 HOH 4  304 22  HOH HOH H . 
F 5 HOH 5  305 79  HOH HOH H . 
F 5 HOH 6  306 122 HOH HOH H . 
F 5 HOH 7  307 67  HOH HOH H . 
F 5 HOH 8  308 160 HOH HOH H . 
F 5 HOH 9  309 119 HOH HOH H . 
F 5 HOH 10 310 114 HOH HOH H . 
F 5 HOH 11 311 26  HOH HOH H . 
F 5 HOH 12 312 149 HOH HOH H . 
F 5 HOH 13 313 103 HOH HOH H . 
F 5 HOH 14 314 153 HOH HOH H . 
F 5 HOH 15 315 30  HOH HOH H . 
F 5 HOH 16 316 60  HOH HOH H . 
F 5 HOH 17 317 80  HOH HOH H . 
F 5 HOH 18 318 81  HOH HOH H . 
F 5 HOH 19 319 158 HOH HOH H . 
F 5 HOH 20 320 141 HOH HOH H . 
F 5 HOH 21 321 131 HOH HOH H . 
F 5 HOH 22 322 43  HOH HOH H . 
F 5 HOH 23 323 148 HOH HOH H . 
F 5 HOH 24 324 106 HOH HOH H . 
F 5 HOH 25 325 44  HOH HOH H . 
F 5 HOH 26 326 129 HOH HOH H . 
F 5 HOH 27 327 89  HOH HOH H . 
F 5 HOH 28 328 125 HOH HOH H . 
F 5 HOH 29 329 104 HOH HOH H . 
F 5 HOH 30 330 111 HOH HOH H . 
F 5 HOH 31 331 133 HOH HOH H . 
F 5 HOH 32 332 45  HOH HOH H . 
F 5 HOH 33 333 139 HOH HOH H . 
F 5 HOH 34 334 99  HOH HOH H . 
F 5 HOH 35 335 156 HOH HOH H . 
F 5 HOH 36 336 32  HOH HOH H . 
F 5 HOH 37 337 16  HOH HOH H . 
F 5 HOH 38 338 146 HOH HOH H . 
F 5 HOH 39 339 147 HOH HOH H . 
F 5 HOH 40 340 71  HOH HOH H . 
F 5 HOH 41 341 62  HOH HOH H . 
F 5 HOH 42 342 136 HOH HOH H . 
F 5 HOH 43 343 93  HOH HOH H . 
F 5 HOH 44 344 155 HOH HOH H . 
F 5 HOH 45 345 70  HOH HOH H . 
F 5 HOH 46 346 159 HOH HOH H . 
F 5 HOH 47 347 95  HOH HOH H . 
F 5 HOH 48 348 51  HOH HOH H . 
F 5 HOH 49 349 117 HOH HOH H . 
F 5 HOH 50 350 144 HOH HOH H . 
F 5 HOH 51 351 107 HOH HOH H . 
F 5 HOH 52 352 33  HOH HOH H . 
F 5 HOH 53 353 74  HOH HOH H . 
F 5 HOH 54 354 168 HOH HOH H . 
F 5 HOH 55 355 100 HOH HOH H . 
F 5 HOH 56 356 25  HOH HOH H . 
F 5 HOH 57 357 12  HOH HOH H . 
F 5 HOH 58 358 69  HOH HOH H . 
F 5 HOH 59 359 65  HOH HOH H . 
F 5 HOH 60 360 162 HOH HOH H . 
F 5 HOH 61 361 17  HOH HOH H . 
F 5 HOH 62 362 2   HOH HOH H . 
F 5 HOH 63 363 5   HOH HOH H . 
F 5 HOH 64 364 49  HOH HOH H . 
F 5 HOH 65 365 1   HOH HOH H . 
F 5 HOH 66 366 151 HOH HOH H . 
F 5 HOH 67 367 172 HOH HOH H . 
F 5 HOH 68 368 134 HOH HOH H . 
F 5 HOH 69 369 171 HOH HOH H . 
F 5 HOH 70 370 55  HOH HOH H . 
F 5 HOH 71 371 173 HOH HOH H . 
F 5 HOH 72 372 170 HOH HOH H . 
G 5 HOH 1  301 96  HOH HOH L . 
G 5 HOH 2  302 64  HOH HOH L . 
G 5 HOH 3  303 91  HOH HOH L . 
G 5 HOH 4  304 38  HOH HOH L . 
G 5 HOH 5  305 57  HOH HOH L . 
G 5 HOH 6  306 142 HOH HOH L . 
G 5 HOH 7  307 20  HOH HOH L . 
G 5 HOH 8  308 24  HOH HOH L . 
G 5 HOH 9  309 66  HOH HOH L . 
G 5 HOH 10 310 86  HOH HOH L . 
G 5 HOH 11 311 75  HOH HOH L . 
G 5 HOH 12 312 108 HOH HOH L . 
G 5 HOH 13 313 140 HOH HOH L . 
G 5 HOH 14 314 102 HOH HOH L . 
G 5 HOH 15 315 42  HOH HOH L . 
G 5 HOH 16 316 48  HOH HOH L . 
G 5 HOH 17 317 28  HOH HOH L . 
G 5 HOH 18 318 166 HOH HOH L . 
G 5 HOH 19 319 116 HOH HOH L . 
G 5 HOH 20 320 11  HOH HOH L . 
G 5 HOH 21 321 50  HOH HOH L . 
G 5 HOH 22 322 112 HOH HOH L . 
G 5 HOH 23 323 90  HOH HOH L . 
G 5 HOH 24 324 58  HOH HOH L . 
G 5 HOH 25 325 61  HOH HOH L . 
G 5 HOH 26 326 124 HOH HOH L . 
G 5 HOH 27 327 52  HOH HOH L . 
G 5 HOH 28 328 118 HOH HOH L . 
G 5 HOH 29 329 101 HOH HOH L . 
G 5 HOH 30 330 126 HOH HOH L . 
G 5 HOH 31 331 154 HOH HOH L . 
G 5 HOH 32 332 109 HOH HOH L . 
G 5 HOH 33 333 97  HOH HOH L . 
G 5 HOH 34 334 113 HOH HOH L . 
G 5 HOH 35 335 19  HOH HOH L . 
G 5 HOH 36 336 138 HOH HOH L . 
G 5 HOH 37 337 72  HOH HOH L . 
G 5 HOH 38 338 110 HOH HOH L . 
G 5 HOH 39 339 77  HOH HOH L . 
H 5 HOH 1  301 150 HOH HOH C . 
H 5 HOH 2  302 164 HOH HOH C . 
H 5 HOH 3  303 120 HOH HOH C . 
H 5 HOH 4  304 4   HOH HOH C . 
H 5 HOH 5  305 115 HOH HOH C . 
H 5 HOH 6  306 165 HOH HOH C . 
H 5 HOH 7  307 87  HOH HOH C . 
H 5 HOH 8  308 31  HOH HOH C . 
H 5 HOH 9  309 94  HOH HOH C . 
H 5 HOH 10 310 15  HOH HOH C . 
H 5 HOH 11 311 7   HOH HOH C . 
H 5 HOH 12 312 105 HOH HOH C . 
H 5 HOH 13 313 132 HOH HOH C . 
H 5 HOH 14 314 21  HOH HOH C . 
H 5 HOH 15 315 128 HOH HOH C . 
H 5 HOH 16 316 161 HOH HOH C . 
H 5 HOH 17 317 23  HOH HOH C . 
H 5 HOH 18 318 6   HOH HOH C . 
H 5 HOH 19 319 14  HOH HOH C . 
H 5 HOH 20 320 169 HOH HOH C . 
H 5 HOH 21 321 39  HOH HOH C . 
H 5 HOH 22 322 56  HOH HOH C . 
H 5 HOH 23 323 130 HOH HOH C . 
H 5 HOH 24 324 85  HOH HOH C . 
H 5 HOH 25 325 29  HOH HOH C . 
H 5 HOH 26 326 157 HOH HOH C . 
H 5 HOH 27 327 36  HOH HOH C . 
H 5 HOH 28 328 27  HOH HOH C . 
H 5 HOH 29 329 37  HOH HOH C . 
H 5 HOH 30 330 123 HOH HOH C . 
H 5 HOH 31 331 3   HOH HOH C . 
H 5 HOH 32 332 76  HOH HOH C . 
H 5 HOH 33 333 92  HOH HOH C . 
H 5 HOH 34 334 59  HOH HOH C . 
H 5 HOH 35 335 163 HOH HOH C . 
H 5 HOH 36 336 9   HOH HOH C . 
H 5 HOH 37 337 73  HOH HOH C . 
H 5 HOH 38 338 127 HOH HOH C . 
H 5 HOH 39 339 68  HOH HOH C . 
H 5 HOH 40 340 121 HOH HOH C . 
H 5 HOH 41 341 13  HOH HOH C . 
H 5 HOH 42 342 54  HOH HOH C . 
H 5 HOH 43 343 10  HOH HOH C . 
H 5 HOH 44 344 18  HOH HOH C . 
H 5 HOH 45 345 53  HOH HOH C . 
H 5 HOH 46 346 63  HOH HOH C . 
H 5 HOH 47 347 34  HOH HOH C . 
H 5 HOH 48 348 78  HOH HOH C . 
H 5 HOH 49 349 8   HOH HOH C . 
H 5 HOH 50 350 88  HOH HOH C . 
H 5 HOH 51 351 35  HOH HOH C . 
H 5 HOH 52 352 83  HOH HOH C . 
H 5 HOH 53 353 46  HOH HOH C . 
H 5 HOH 54 354 40  HOH HOH C . 
H 5 HOH 55 355 84  HOH HOH C . 
H 5 HOH 56 356 41  HOH HOH C . 
H 5 HOH 57 357 98  HOH HOH C . 
H 5 HOH 58 358 47  HOH HOH C . 
H 5 HOH 59 359 135 HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.2_5419 1 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless  ? ? ? .           4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MIC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     53.435 
_cell.length_a_esd                 ? 
_cell.length_b                     71.291 
_cell.length_b_esd                 ? 
_cell.length_c                     219.335 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MIC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MIC 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.14 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          60.82 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'1.2 M sodium dihydrogen phosphate, 0.1M CAPS, 0.8M di-potassium hydrogen phosphate, 25% glycerol, 0.2M lithium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9MIC 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.97 
_reflns.d_resolution_low                               33.90 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     60382 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.97 
_reflns_shell.d_res_low                                     2.00 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2805 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.39 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MIC 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.97 
_refine.ls_d_res_low                             33.90 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     60352 
_refine.ls_number_reflns_R_free                  2987 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 4.95 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2231 
_refine.ls_R_factor_R_free                       0.2520 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2216 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.41 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.27 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.97 
_refine_hist.d_res_low                        33.90 
_refine_hist.number_atoms_solvent             170 
_refine_hist.number_atoms_total               4733 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4535 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         28 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  ? ?    ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.012  ? ?    ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 17.227 ? 1700 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.063  ? 725  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009  ? 811  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.97 2.00  . . 124 2670 100.00 . . . . 0.3130 . . . . . . . . . . . 0.3789 
'X-RAY DIFFRACTION' 2.00 2.04  . . 145 2709 100.00 . . . . 0.3121 . . . . . . . . . . . 0.3258 
'X-RAY DIFFRACTION' 2.04 2.07  . . 127 2699 100.00 . . . . 0.2904 . . . . . . . . . . . 0.3538 
'X-RAY DIFFRACTION' 2.07 2.11  . . 144 2698 100.00 . . . . 0.2892 . . . . . . . . . . . 0.3095 
'X-RAY DIFFRACTION' 2.11 2.16  . . 138 2677 100.00 . . . . 0.2766 . . . . . . . . . . . 0.3341 
'X-RAY DIFFRACTION' 2.16 2.20  . . 147 2657 100.00 . . . . 0.2632 . . . . . . . . . . . 0.2988 
'X-RAY DIFFRACTION' 2.20 2.25  . . 149 2713 100.00 . . . . 0.2545 . . . . . . . . . . . 0.2623 
'X-RAY DIFFRACTION' 2.25 2.31  . . 154 2706 100.00 . . . . 0.2466 . . . . . . . . . . . 0.2974 
'X-RAY DIFFRACTION' 2.31 2.37  . . 149 2675 100.00 . . . . 0.2445 . . . . . . . . . . . 0.2976 
'X-RAY DIFFRACTION' 2.37 2.44  . . 140 2720 100.00 . . . . 0.2395 . . . . . . . . . . . 0.2939 
'X-RAY DIFFRACTION' 2.44 2.52  . . 130 2727 100.00 . . . . 0.2390 . . . . . . . . . . . 0.2834 
'X-RAY DIFFRACTION' 2.52 2.61  . . 152 2690 100.00 . . . . 0.2250 . . . . . . . . . . . 0.2879 
'X-RAY DIFFRACTION' 2.61 2.72  . . 133 2747 100.00 . . . . 0.2267 . . . . . . . . . . . 0.2430 
'X-RAY DIFFRACTION' 2.72 2.84  . . 142 2718 100.00 . . . . 0.2231 . . . . . . . . . . . 0.3008 
'X-RAY DIFFRACTION' 2.84 2.99  . . 156 2746 100.00 . . . . 0.2218 . . . . . . . . . . . 0.2662 
'X-RAY DIFFRACTION' 2.99 3.18  . . 118 2750 100.00 . . . . 0.2185 . . . . . . . . . . . 0.2312 
'X-RAY DIFFRACTION' 3.18 3.42  . . 118 2768 100.00 . . . . 0.2117 . . . . . . . . . . . 0.2811 
'X-RAY DIFFRACTION' 3.42 3.77  . . 125 2774 100.00 . . . . 0.2044 . . . . . . . . . . . 0.2208 
'X-RAY DIFFRACTION' 3.77 4.31  . . 165 2765 100.00 . . . . 0.1870 . . . . . . . . . . . 0.2025 
'X-RAY DIFFRACTION' 4.31 5.43  . . 164 2808 100.00 . . . . 0.1819 . . . . . . . . . . . 0.1992 
'X-RAY DIFFRACTION' 5.43 33.90 . . 167 2948 100.00 . . . . 0.2138 . . . . . . . . . . . 0.2187 
# 
_struct.entry_id                     9MIC 
_struct.title                        
'Crystal structure of the VRC01-class antibody 4D01, derived from GT1.1 vaccination, in complex with eOD-GT8' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MIC 
_struct_keywords.text            'HIV-1, Germline-targeting vaccination, CD4bs mAb, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
H N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9MIC 9MIC ? 1 ? 1 
2 PDB 9MIC 9MIC ? 2 ? 1 
3 PDB 9MIC 9MIC ? 3 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9MIC H 1 ? 224 ? 9MIC 1 ? 217 ? 1 217 
2 2 9MIC L 1 ? 208 ? 9MIC 1 ? 212 ? 1 212 
3 3 9MIC C 1 ? 183 ? 9MIC 1 ? 183 ? 1 183 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6430  ? 
1 MORE         -16   ? 
1 'SSA (A^2)'  25010 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 28  ? THR A 30  ? THR H 28  THR H 30  5 ? 3  
HELX_P HELX_P2  AA2 HIS A 62  ? GLN A 65  ? HIS H 61  GLN H 64  5 ? 4  
HELX_P HELX_P3  AA3 THR A 74  ? ILE A 76  ? THR H 73  ILE H 75  5 ? 3  
HELX_P HELX_P4  AA4 THR A 87  ? THR A 91  ? THR H 83  THR H 87  5 ? 5  
HELX_P HELX_P5  AA5 SER A 163 ? ALA A 165 ? SER H 156 ALA H 158 5 ? 3  
HELX_P HELX_P6  AA6 SER A 194 ? LEU A 196 ? SER H 187 LEU H 189 5 ? 3  
HELX_P HELX_P7  AA7 LYS A 208 ? ASN A 211 ? LYS H 201 ASN H 204 5 ? 4  
HELX_P HELX_P8  AA8 GLN B 79  ? PHE B 83  ? GLN L 79  PHE L 83  5 ? 5  
HELX_P HELX_P9  AA9 SER B 117 ? SER B 123 ? SER L 121 SER L 127 1 ? 7  
HELX_P HELX_P10 AB1 LYS B 179 ? GLU B 183 ? LYS L 183 GLU L 187 1 ? 5  
HELX_P HELX_P11 AB2 GLY B 206 ? CYS B 208 ? GLY L 210 CYS L 212 5 ? 3  
HELX_P HELX_P12 AB3 PRO C 12  ? SER C 16  ? PRO C 12  SER C 16  5 ? 5  
HELX_P HELX_P13 AB4 ASP C 44  ? GLN C 52  ? ASP C 44  GLN C 52  1 ? 9  
HELX_P HELX_P14 AB5 ARG C 109 ? GLY C 128 ? ARG C 109 GLY C 128 1 ? 20 
HELX_P HELX_P15 AB6 ASP C 141 ? ASN C 146 ? ASP C 141 ASN C 146 1 ? 6  
HELX_P HELX_P16 AB7 SER C 160 ? PHE C 164 ? SER C 160 PHE C 164 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 22  SG  ? ? ? 1_555 A CYS 96  SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.065 ? ?               
disulf2 disulf ?   ? A CYS 147 SG  ? ? ? 1_555 A CYS 203 SG ? ? H CYS 140 H CYS 196 1_555 ? ? ? ? ? ? ? 2.053 ? ?               
disulf3 disulf ?   ? B CYS 23  SG  ? ? ? 1_555 B CYS 88  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.057 ? ?               
disulf4 disulf ?   ? B CYS 130 SG  ? ? ? 1_555 B CYS 190 SG ? ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf5 disulf ?   ? C CYS 7   SG  ? ? ? 1_555 C CYS 158 SG ? ? C CYS 7   C CYS 158 1_555 ? ? ? ? ? ? ? 2.067 ? ?               
disulf6 disulf ?   ? C CYS 15  SG  ? ? ? 1_555 C CYS 151 SG ? ? C CYS 15  C CYS 151 1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf7 disulf ?   ? C CYS 51  SG  ? ? ? 1_555 C CYS 88  SG ? ? C CYS 51  C CYS 88  1_555 ? ? ? ? ? ? ? 1.991 ? ?               
disulf8 disulf ?   ? C CYS 99  SG  ? ? ? 1_555 C CYS 105 SG ? ? C CYS 99  C CYS 105 1_555 ? ? ? ? ? ? ? 2.074 ? ?               
covale1 covale one ? C ASN 18  ND2 ? ? ? 1_555 D NAG .   C1 ? ? C ASN 18  C NAG 201 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale2 covale one ? C ASN 65  ND2 ? ? ? 1_555 E NAG .   C1 ? ? C ASN 65  C NAG 202 1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG D .   ? ASN C 18  ? NAG C 201 ? 1_555 ASN C 18  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG E .   ? ASN C 65  ? NAG C 202 ? 1_555 ASN C 65  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  CYS A 22  ? CYS A 96  ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS A 147 ? CYS A 203 ? CYS H 140 ? 1_555 CYS H 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS B 23  ? CYS B 88  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS B 130 ? CYS B 190 ? CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS C 7   ? CYS C 158 ? CYS C 7   ? 1_555 CYS C 158 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS C 15  ? CYS C 151 ? CYS C 15  ? 1_555 CYS C 151 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS C 51  ? CYS C 88  ? CYS C 51  ? 1_555 CYS C 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS C 99  ? CYS C 105 ? CYS C 99  ? 1_555 CYS C 105 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 153 A . ? PHE 146 H PRO 154 A ? PRO 147 H 1 -8.07  
2 GLU 155 A . ? GLU 148 H PRO 156 A ? PRO 149 H 1 0.04   
3 SER 7   B . ? SER 7   L PRO 8   B ? PRO 8   L 1 -10.19 
4 TYR 136 B . ? TYR 140 L PRO 137 B ? PRO 141 L 1 0.42   
5 ARG 8   C . ? ARG 8   C PRO 9   C ? PRO 9   C 1 -12.55 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 3 ? 
AA7 ? 4 ? 
AA8 ? 6 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 7 ? 
AB4 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
AA8 5 6 ? anti-parallel 
AA9 1 2 ? parallel      
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB3 4 5 ? anti-parallel 
AB3 5 6 ? anti-parallel 
AB3 6 7 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB4 4 5 ? parallel      
AB4 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 3   ? GLN A 6   ? GLN H 3   GLN H 6   
AA1 2 VAL A 18  ? SER A 25  ? VAL H 18  SER H 25  
AA1 3 THR A 78  ? LEU A 83  ? THR H 77  LEU H 82  
AA1 4 VAL A 68  ? ASP A 73  ? VAL H 67  ASP H 72  
AA2 1 GLU A 10  ? LYS A 12  ? GLU H 10  LYS H 12  
AA2 2 THR A 114 ? VAL A 118 ? THR H 107 VAL H 111 
AA2 3 GLY A 92  ? PRO A 100 ? GLY H 88  PRO H 96  
AA2 4 PHE A 32  ? GLN A 39  ? PHE H 32  GLN H 39  
AA2 5 LEU A 45  ? ILE A 51  ? LEU H 45  ILE H 51  
AA2 6 VAL A 58  ? TYR A 60  ? VAL H 57  TYR H 59  
AA3 1 GLU A 10  ? LYS A 12  ? GLU H 10  LYS H 12  
AA3 2 THR A 114 ? VAL A 118 ? THR H 107 VAL H 111 
AA3 3 GLY A 92  ? PRO A 100 ? GLY H 88  PRO H 96  
AA3 4 TYR A 109 ? TRP A 110 ? TYR H 102 TRP H 103 
AA4 1 SER A 127 ? LEU A 131 ? SER H 120 LEU H 124 
AA4 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA4 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA4 4 VAL A 170 ? THR A 172 ? VAL H 163 THR H 165 
AA5 1 THR A 138 ? SER A 139 ? THR H 131 SER H 132 
AA5 2 THR A 142 ? TYR A 152 ? THR H 135 TYR H 145 
AA5 3 TYR A 183 ? PRO A 192 ? TYR H 176 PRO H 185 
AA5 4 VAL A 176 ? LEU A 177 ? VAL H 169 LEU H 170 
AA6 1 THR A 158 ? TRP A 161 ? THR H 151 TRP H 154 
AA6 2 ILE A 202 ? HIS A 207 ? ILE H 195 HIS H 200 
AA6 3 THR A 212 ? ARG A 217 ? THR H 205 ARG H 210 
AA7 1 VAL B 4   ? SER B 7   ? VAL L 4   SER L 7   
AA7 2 VAL B 19  ? ALA B 25  ? VAL L 19  ALA L 25  
AA7 3 ASP B 70  ? ILE B 75  ? ASP L 70  ILE L 75  
AA7 4 PHE B 62  ? SER B 65  ? PHE L 62  SER L 65  
AA8 1 SER B 10  ? ALA B 13  ? SER L 10  ALA L 13  
AA8 2 THR B 98  ? ILE B 102 ? THR L 102 ILE L 106 
AA8 3 THR B 85  ? ILE B 90  ? THR L 85  ILE L 90  
AA8 4 LEU B 33  ? GLN B 38  ? LEU L 33  GLN L 38  
AA8 5 LYS B 45  ? TYR B 49  ? LYS L 45  TYR L 49  
AA8 6 THR B 53  ? LEU B 54  ? THR L 53  LEU L 54  
AA9 1 SER B 10  ? ALA B 13  ? SER L 10  ALA L 13  
AA9 2 THR B 98  ? ILE B 102 ? THR L 102 ILE L 106 
AA9 3 THR B 85  ? ILE B 90  ? THR L 85  ILE L 90  
AA9 4 THR B 93  ? PHE B 94  ? THR L 97  PHE L 98  
AB1 1 SER B 110 ? PHE B 114 ? SER L 114 PHE L 118 
AB1 2 THR B 125 ? PHE B 135 ? THR L 129 PHE L 139 
AB1 3 TYR B 169 ? SER B 178 ? TYR L 173 SER L 182 
AB1 4 SER B 155 ? VAL B 159 ? SER L 159 VAL L 163 
AB2 1 ALA B 149 ? LEU B 150 ? ALA L 153 LEU L 154 
AB2 2 LYS B 141 ? VAL B 146 ? LYS L 145 VAL L 150 
AB2 3 VAL B 187 ? THR B 193 ? VAL L 191 THR L 197 
AB2 4 SER B 198 ? ASN B 204 ? SER L 202 ASN L 208 
AB3 1 LEU C 62  ? LEU C 64  ? LEU C 62  LEU C 64  
AB3 2 SER C 17  ? ARG C 26  ? SER C 17  ARG C 26  
AB3 3 ILE C 87  ? CYS C 99  ? ILE C 87  CYS C 99  
AB3 4 HIS C 104 ? SER C 108 ? HIS C 104 SER C 108 
AB3 5 THR C 2   ? ARG C 8   ? THR C 2   ARG C 8   
AB3 6 GLU C 154 ? CYS C 158 ? GLU C 154 CYS C 158 
AB3 7 HIS C 147 ? CYS C 151 ? HIS C 147 CYS C 151 
AB4 1 VAL C 74  ? ARG C 76  ? VAL C 74  ARG C 76  
AB4 2 ILE C 87  ? CYS C 99  ? ILE C 87  CYS C 99  
AB4 3 SER C 17  ? ARG C 26  ? SER C 17  ARG C 26  
AB4 4 THR C 35  ? PRO C 40  ? THR C 35  PRO C 40  
AB4 5 THR C 131 ? PHE C 134 ? THR C 131 PHE C 134 
AB4 6 SER C 166 ? TRP C 168 ? SER C 166 TRP C 168 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 5   ? N VAL H 5   O LYS A 23  ? O LYS H 23  
AA1 2 3 N VAL A 20  ? N VAL H 20  O MET A 81  ? O MET H 80  
AA1 3 4 O TYR A 80  ? O TYR H 79  N THR A 71  ? N THR H 70  
AA2 1 2 N GLU A 10  ? N GLU H 10  O LEU A 115 ? O LEU H 108 
AA2 2 3 O VAL A 116 ? O VAL H 109 N GLY A 92  ? N GLY H 88  
AA2 3 4 O TYR A 95  ? O TYR H 91  N MET A 37  ? N MET H 37  
AA2 4 5 N TRP A 36  ? N TRP H 36  O MET A 48  ? O MET H 48  
AA2 5 6 N TRP A 50  ? N TRP H 50  O ASN A 59  ? O ASN H 58  
AA3 1 2 N GLU A 10  ? N GLU H 10  O LEU A 115 ? O LEU H 108 
AA3 2 3 O VAL A 116 ? O VAL H 109 N GLY A 92  ? N GLY H 88  
AA3 3 4 N ARG A 98  ? N ARG H 94  O TYR A 109 ? O TYR H 102 
AA4 1 2 N PHE A 129 ? N PHE H 122 O LEU A 148 ? O LEU H 141 
AA4 2 3 N VAL A 149 ? N VAL H 142 O LEU A 185 ? O LEU H 178 
AA4 3 4 O VAL A 188 ? O VAL H 181 N HIS A 171 ? N HIS H 164 
AA5 1 2 N SER A 139 ? N SER H 132 O THR A 142 ? O THR H 135 
AA5 2 3 N VAL A 149 ? N VAL H 142 O LEU A 185 ? O LEU H 178 
AA5 3 4 O SER A 184 ? O SER H 177 N VAL A 176 ? N VAL H 169 
AA6 1 2 N THR A 158 ? N THR H 151 O ASN A 206 ? O ASN H 199 
AA6 2 3 N VAL A 205 ? N VAL H 198 O VAL A 214 ? O VAL H 207 
AA7 1 2 N SER B 7   ? N SER L 7   O THR B 22  ? O THR L 22  
AA7 2 3 N ILE B 21  ? N ILE L 21  O LEU B 73  ? O LEU L 73  
AA7 3 4 O THR B 74  ? O THR L 74  N SER B 63  ? N SER L 63  
AA8 1 2 N LEU B 11  ? N LEU L 11  O ASP B 101 ? O ASP L 105 
AA8 2 3 O THR B 98  ? O THR L 102 N TYR B 86  ? N TYR L 86  
AA8 3 4 O THR B 85  ? O THR L 85  N GLN B 38  ? N GLN L 38  
AA8 4 5 N GLN B 37  ? N GLN L 37  O LYS B 45  ? O LYS L 45  
AA8 5 6 N TYR B 49  ? N TYR L 49  O THR B 53  ? O THR L 53  
AA9 1 2 N LEU B 11  ? N LEU L 11  O ASP B 101 ? O ASP L 105 
AA9 2 3 O THR B 98  ? O THR L 102 N TYR B 86  ? N TYR L 86  
AA9 3 4 N ILE B 90  ? N ILE L 90  O THR B 93  ? O THR L 97  
AB1 1 2 N SER B 110 ? N SER L 114 O ASN B 133 ? O ASN L 137 
AB1 2 3 N VAL B 128 ? N VAL L 132 O LEU B 175 ? O LEU L 179 
AB1 3 4 O THR B 174 ? O THR L 178 N GLN B 156 ? N GLN L 160 
AB2 1 2 O ALA B 149 ? O ALA L 153 N VAL B 146 ? N VAL L 150 
AB2 2 3 N GLN B 143 ? N GLN L 147 O GLU B 191 ? O GLU L 195 
AB2 3 4 N VAL B 192 ? N VAL L 196 O VAL B 199 ? O VAL L 203 
AB3 1 2 O PHE C 63  ? O PHE C 63  N GLY C 21  ? N GLY C 21  
AB3 2 3 N ILE C 19  ? N ILE C 19  O VAL C 95  ? O VAL C 95  
AB3 3 4 N ALA C 98  ? N ALA C 98  O ALA C 106 ? O ALA C 106 
AB3 4 5 O ILE C 107 ? O ILE C 107 N ILE C 3   ? N ILE C 3   
AB3 5 6 N ARG C 8   ? N ARG C 8   O TYR C 157 ? O TYR C 157 
AB3 6 7 O CYS C 158 ? O CYS C 158 N HIS C 147 ? N HIS C 147 
AB4 1 2 N ARG C 76  ? N ARG C 76  O CYS C 88  ? O CYS C 88  
AB4 2 3 O VAL C 95  ? O VAL C 95  N ILE C 19  ? N ILE C 19  
AB4 3 4 N THR C 25  ? N THR C 25  O ARG C 39  ? O ARG C 39  
AB4 4 5 N PHE C 38  ? N PHE C 38  O ILE C 133 ? O ILE C 133 
AB4 5 6 N PHE C 134 ? N PHE C 134 O SER C 166 ? O SER C 166 
# 
_pdbx_entry_details.entry_id                   9MIC 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP H 144 ? ? 60.32   64.67   
2  1 SER L 30  ? ? 60.93   -124.87 
3  1 ALA L 51  ? ? 70.47   -23.04  
4  1 TYR L 91  ? ? 44.47   -120.99 
5  1 SER L 156 ? ? 43.10   74.15   
6  1 PRO C 9   ? ? -59.52  170.71  
7  1 ASN C 32  ? ? 69.57   90.85   
8  1 ASP C 44  ? ? -117.59 -163.44 
9  1 GLN C 61  ? ? 65.31   -35.12  
10 1 ASP C 79  ? ? -162.15 108.70  
11 1 ALA C 165 ? ? -158.42 81.70   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 H SER 215 ? A SER 222 
2  1 Y 1 H CYS 216 ? A CYS 223 
3  1 Y 1 H ASP 217 ? A ASP 224 
4  1 Y 1 L ASP 1   ? B ASP 1   
5  1 Y 1 C ALA 170 ? C ALA 170 
6  1 Y 1 C SER 171 ? C SER 171 
7  1 Y 1 C THR 172 ? C THR 172 
8  1 Y 1 C GLY 173 ? C GLY 173 
9  1 Y 1 C THR 174 ? C THR 174 
10 1 Y 1 C GLY 175 ? C GLY 175 
11 1 Y 1 C THR 176 ? C THR 176 
12 1 Y 1 C LYS 177 ? C LYS 177 
13 1 Y 1 C HIS 178 ? C HIS 178 
14 1 Y 1 C HIS 179 ? C HIS 179 
15 1 Y 1 C HIS 180 ? C HIS 180 
16 1 Y 1 C HIS 181 ? C HIS 181 
17 1 Y 1 C HIS 182 ? C HIS 182 
18 1 Y 1 C HIS 183 ? C HIS 183 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
NAG C1   C N R 250 
NAG C2   C N R 251 
NAG C3   C N R 252 
NAG C4   C N S 253 
NAG C5   C N R 254 
NAG C6   C N N 255 
NAG C7   C N N 256 
NAG C8   C N N 257 
NAG N2   N N N 258 
NAG O1   O N N 259 
NAG O3   O N N 260 
NAG O4   O N N 261 
NAG O5   O N N 262 
NAG O6   O N N 263 
NAG O7   O N N 264 
NAG H1   H N N 265 
NAG H2   H N N 266 
NAG H3   H N N 267 
NAG H4   H N N 268 
NAG H5   H N N 269 
NAG H61  H N N 270 
NAG H62  H N N 271 
NAG H81  H N N 272 
NAG H82  H N N 273 
NAG H83  H N N 274 
NAG HN2  H N N 275 
NAG HO1  H N N 276 
NAG HO3  H N N 277 
NAG HO4  H N N 278 
NAG HO6  H N N 279 
PHE N    N N N 280 
PHE CA   C N S 281 
PHE C    C N N 282 
PHE O    O N N 283 
PHE CB   C N N 284 
PHE CG   C Y N 285 
PHE CD1  C Y N 286 
PHE CD2  C Y N 287 
PHE CE1  C Y N 288 
PHE CE2  C Y N 289 
PHE CZ   C Y N 290 
PHE OXT  O N N 291 
PHE H    H N N 292 
PHE H2   H N N 293 
PHE HA   H N N 294 
PHE HB2  H N N 295 
PHE HB3  H N N 296 
PHE HD1  H N N 297 
PHE HD2  H N N 298 
PHE HE1  H N N 299 
PHE HE2  H N N 300 
PHE HZ   H N N 301 
PHE HXT  H N N 302 
PRO N    N N N 303 
PRO CA   C N S 304 
PRO C    C N N 305 
PRO O    O N N 306 
PRO CB   C N N 307 
PRO CG   C N N 308 
PRO CD   C N N 309 
PRO OXT  O N N 310 
PRO H    H N N 311 
PRO HA   H N N 312 
PRO HB2  H N N 313 
PRO HB3  H N N 314 
PRO HG2  H N N 315 
PRO HG3  H N N 316 
PRO HD2  H N N 317 
PRO HD3  H N N 318 
PRO HXT  H N N 319 
SER N    N N N 320 
SER CA   C N S 321 
SER C    C N N 322 
SER O    O N N 323 
SER CB   C N N 324 
SER OG   O N N 325 
SER OXT  O N N 326 
SER H    H N N 327 
SER H2   H N N 328 
SER HA   H N N 329 
SER HB2  H N N 330 
SER HB3  H N N 331 
SER HG   H N N 332 
SER HXT  H N N 333 
THR N    N N N 334 
THR CA   C N S 335 
THR C    C N N 336 
THR O    O N N 337 
THR CB   C N R 338 
THR OG1  O N N 339 
THR CG2  C N N 340 
THR OXT  O N N 341 
THR H    H N N 342 
THR H2   H N N 343 
THR HA   H N N 344 
THR HB   H N N 345 
THR HG1  H N N 346 
THR HG21 H N N 347 
THR HG22 H N N 348 
THR HG23 H N N 349 
THR HXT  H N N 350 
TRP N    N N N 351 
TRP CA   C N S 352 
TRP C    C N N 353 
TRP O    O N N 354 
TRP CB   C N N 355 
TRP CG   C Y N 356 
TRP CD1  C Y N 357 
TRP CD2  C Y N 358 
TRP NE1  N Y N 359 
TRP CE2  C Y N 360 
TRP CE3  C Y N 361 
TRP CZ2  C Y N 362 
TRP CZ3  C Y N 363 
TRP CH2  C Y N 364 
TRP OXT  O N N 365 
TRP H    H N N 366 
TRP H2   H N N 367 
TRP HA   H N N 368 
TRP HB2  H N N 369 
TRP HB3  H N N 370 
TRP HD1  H N N 371 
TRP HE1  H N N 372 
TRP HE3  H N N 373 
TRP HZ2  H N N 374 
TRP HZ3  H N N 375 
TRP HH2  H N N 376 
TRP HXT  H N N 377 
TYR N    N N N 378 
TYR CA   C N S 379 
TYR C    C N N 380 
TYR O    O N N 381 
TYR CB   C N N 382 
TYR CG   C Y N 383 
TYR CD1  C Y N 384 
TYR CD2  C Y N 385 
TYR CE1  C Y N 386 
TYR CE2  C Y N 387 
TYR CZ   C Y N 388 
TYR OH   O N N 389 
TYR OXT  O N N 390 
TYR H    H N N 391 
TYR H2   H N N 392 
TYR HA   H N N 393 
TYR HB2  H N N 394 
TYR HB3  H N N 395 
TYR HD1  H N N 396 
TYR HD2  H N N 397 
TYR HE1  H N N 398 
TYR HE2  H N N 399 
TYR HH   H N N 400 
TYR HXT  H N N 401 
VAL N    N N N 402 
VAL CA   C N S 403 
VAL C    C N N 404 
VAL O    O N N 405 
VAL CB   C N N 406 
VAL CG1  C N N 407 
VAL CG2  C N N 408 
VAL OXT  O N N 409 
VAL H    H N N 410 
VAL H2   H N N 411 
VAL HA   H N N 412 
VAL HB   H N N 413 
VAL HG11 H N N 414 
VAL HG12 H N N 415 
VAL HG13 H N N 416 
VAL HG21 H N N 417 
VAL HG22 H N N 418 
VAL HG23 H N N 419 
VAL HXT  H N N 420 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAG C1  C2   sing N N 237 
NAG C1  O1   sing N N 238 
NAG C1  O5   sing N N 239 
NAG C1  H1   sing N N 240 
NAG C2  C3   sing N N 241 
NAG C2  N2   sing N N 242 
NAG C2  H2   sing N N 243 
NAG C3  C4   sing N N 244 
NAG C3  O3   sing N N 245 
NAG C3  H3   sing N N 246 
NAG C4  C5   sing N N 247 
NAG C4  O4   sing N N 248 
NAG C4  H4   sing N N 249 
NAG C5  C6   sing N N 250 
NAG C5  O5   sing N N 251 
NAG C5  H5   sing N N 252 
NAG C6  O6   sing N N 253 
NAG C6  H61  sing N N 254 
NAG C6  H62  sing N N 255 
NAG C7  C8   sing N N 256 
NAG C7  N2   sing N N 257 
NAG C7  O7   doub N N 258 
NAG C8  H81  sing N N 259 
NAG C8  H82  sing N N 260 
NAG C8  H83  sing N N 261 
NAG N2  HN2  sing N N 262 
NAG O1  HO1  sing N N 263 
NAG O3  HO3  sing N N 264 
NAG O4  HO4  sing N N 265 
NAG O6  HO6  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PRO N   CA   sing N N 290 
PRO N   CD   sing N N 291 
PRO N   H    sing N N 292 
PRO CA  C    sing N N 293 
PRO CA  CB   sing N N 294 
PRO CA  HA   sing N N 295 
PRO C   O    doub N N 296 
PRO C   OXT  sing N N 297 
PRO CB  CG   sing N N 298 
PRO CB  HB2  sing N N 299 
PRO CB  HB3  sing N N 300 
PRO CG  CD   sing N N 301 
PRO CG  HG2  sing N N 302 
PRO CG  HG3  sing N N 303 
PRO CD  HD2  sing N N 304 
PRO CD  HD3  sing N N 305 
PRO OXT HXT  sing N N 306 
SER N   CA   sing N N 307 
SER N   H    sing N N 308 
SER N   H2   sing N N 309 
SER CA  C    sing N N 310 
SER CA  CB   sing N N 311 
SER CA  HA   sing N N 312 
SER C   O    doub N N 313 
SER C   OXT  sing N N 314 
SER CB  OG   sing N N 315 
SER CB  HB2  sing N N 316 
SER CB  HB3  sing N N 317 
SER OG  HG   sing N N 318 
SER OXT HXT  sing N N 319 
THR N   CA   sing N N 320 
THR N   H    sing N N 321 
THR N   H2   sing N N 322 
THR CA  C    sing N N 323 
THR CA  CB   sing N N 324 
THR CA  HA   sing N N 325 
THR C   O    doub N N 326 
THR C   OXT  sing N N 327 
THR CB  OG1  sing N N 328 
THR CB  CG2  sing N N 329 
THR CB  HB   sing N N 330 
THR OG1 HG1  sing N N 331 
THR CG2 HG21 sing N N 332 
THR CG2 HG22 sing N N 333 
THR CG2 HG23 sing N N 334 
THR OXT HXT  sing N N 335 
TRP N   CA   sing N N 336 
TRP N   H    sing N N 337 
TRP N   H2   sing N N 338 
TRP CA  C    sing N N 339 
TRP CA  CB   sing N N 340 
TRP CA  HA   sing N N 341 
TRP C   O    doub N N 342 
TRP C   OXT  sing N N 343 
TRP CB  CG   sing N N 344 
TRP CB  HB2  sing N N 345 
TRP CB  HB3  sing N N 346 
TRP CG  CD1  doub Y N 347 
TRP CG  CD2  sing Y N 348 
TRP CD1 NE1  sing Y N 349 
TRP CD1 HD1  sing N N 350 
TRP CD2 CE2  doub Y N 351 
TRP CD2 CE3  sing Y N 352 
TRP NE1 CE2  sing Y N 353 
TRP NE1 HE1  sing N N 354 
TRP CE2 CZ2  sing Y N 355 
TRP CE3 CZ3  doub Y N 356 
TRP CE3 HE3  sing N N 357 
TRP CZ2 CH2  doub Y N 358 
TRP CZ2 HZ2  sing N N 359 
TRP CZ3 CH2  sing Y N 360 
TRP CZ3 HZ3  sing N N 361 
TRP CH2 HH2  sing N N 362 
TRP OXT HXT  sing N N 363 
TYR N   CA   sing N N 364 
TYR N   H    sing N N 365 
TYR N   H2   sing N N 366 
TYR CA  C    sing N N 367 
TYR CA  CB   sing N N 368 
TYR CA  HA   sing N N 369 
TYR C   O    doub N N 370 
TYR C   OXT  sing N N 371 
TYR CB  CG   sing N N 372 
TYR CB  HB2  sing N N 373 
TYR CB  HB3  sing N N 374 
TYR CG  CD1  doub Y N 375 
TYR CG  CD2  sing Y N 376 
TYR CD1 CE1  sing Y N 377 
TYR CD1 HD1  sing N N 378 
TYR CD2 CE2  doub Y N 379 
TYR CD2 HD2  sing N N 380 
TYR CE1 CZ   doub Y N 381 
TYR CE1 HE1  sing N N 382 
TYR CE2 CZ   sing Y N 383 
TYR CE2 HE2  sing N N 384 
TYR CZ  OH   sing N N 385 
TYR OH  HH   sing N N 386 
TYR OXT HXT  sing N N 387 
VAL N   CA   sing N N 388 
VAL N   H    sing N N 389 
VAL N   H2   sing N N 390 
VAL CA  C    sing N N 391 
VAL CA  CB   sing N N 392 
VAL CA  HA   sing N N 393 
VAL C   O    doub N N 394 
VAL C   OXT  sing N N 395 
VAL CB  CG1  sing N N 396 
VAL CB  CG2  sing N N 397 
VAL CB  HB   sing N N 398 
VAL CG1 HG11 sing N N 399 
VAL CG1 HG12 sing N N 400 
VAL CG1 HG13 sing N N 401 
VAL CG2 HG21 sing N N 402 
VAL CG2 HG22 sing N N 403 
VAL CG2 HG23 sing N N 404 
VAL OXT HXT  sing N N 405 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           5P01AI110657 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9MIC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018714 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014027 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004559 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 1   ? 11.968  4.932   41.201  1.00 47.96 ? 1   GLN H N   1 
ATOM   2    C CA  . GLN A 1 1   ? 11.821  4.049   40.044  1.00 50.72 ? 1   GLN H CA  1 
ATOM   3    C C   . GLN A 1 1   ? 10.663  4.453   39.120  1.00 41.24 ? 1   GLN H C   1 
ATOM   4    O O   . GLN A 1 1   ? 10.093  5.525   39.280  1.00 38.68 ? 1   GLN H O   1 
ATOM   5    C CB  . GLN A 1 1   ? 11.633  2.610   40.514  1.00 52.15 ? 1   GLN H CB  1 
ATOM   6    C CG  . GLN A 1 1   ? 12.926  1.921   40.912  1.00 59.14 ? 1   GLN H CG  1 
ATOM   7    C CD  . GLN A 1 1   ? 13.777  1.507   39.711  1.00 71.94 ? 1   GLN H CD  1 
ATOM   8    O OE1 . GLN A 1 1   ? 13.932  2.262   38.738  1.00 68.71 ? 1   GLN H OE1 1 
ATOM   9    N NE2 . GLN A 1 1   ? 14.326  0.293   39.774  1.00 71.81 ? 1   GLN H NE2 1 
ATOM   10   N N   . VAL A 1 2   ? 10.311  3.590   38.161  1.00 43.62 ? 2   VAL H N   1 
ATOM   11   C CA  . VAL A 1 2   ? 9.310   3.941   37.151  1.00 37.75 ? 2   VAL H CA  1 
ATOM   12   C C   . VAL A 1 2   ? 7.919   3.851   37.764  1.00 39.44 ? 2   VAL H C   1 
ATOM   13   O O   . VAL A 1 2   ? 7.553   2.839   38.374  1.00 43.94 ? 2   VAL H O   1 
ATOM   14   C CB  . VAL A 1 2   ? 9.442   3.045   35.907  1.00 40.43 ? 2   VAL H CB  1 
ATOM   15   C CG1 . VAL A 1 2   ? 8.273   3.268   34.938  1.00 35.12 ? 2   VAL H CG1 1 
ATOM   16   C CG2 . VAL A 1 2   ? 10.760  3.344   35.186  1.00 37.08 ? 2   VAL H CG2 1 
ATOM   17   N N   . GLN A 1 3   ? 7.129   4.903   37.579  1.00 37.54 ? 3   GLN H N   1 
ATOM   18   C CA  . GLN A 1 3   ? 5.875   5.074   38.302  1.00 38.97 ? 3   GLN H CA  1 
ATOM   19   C C   . GLN A 1 3   ? 4.850   5.744   37.392  1.00 35.05 ? 3   GLN H C   1 
ATOM   20   O O   . GLN A 1 3   ? 5.057   6.877   36.946  1.00 32.09 ? 3   GLN H O   1 
ATOM   21   C CB  . GLN A 1 3   ? 6.132   5.903   39.573  1.00 39.27 ? 3   GLN H CB  1 
ATOM   22   C CG  . GLN A 1 3   ? 4.960   6.105   40.514  1.00 44.25 ? 3   GLN H CG  1 
ATOM   23   C CD  . GLN A 1 3   ? 5.401   6.484   41.934  1.00 49.94 ? 3   GLN H CD  1 
ATOM   24   O OE1 . GLN A 1 3   ? 6.540   6.241   42.332  1.00 50.38 ? 3   GLN H OE1 1 
ATOM   25   N NE2 . GLN A 1 3   ? 4.492   7.086   42.698  1.00 59.26 ? 3   GLN H NE2 1 
ATOM   26   N N   . LEU A 1 4   ? 3.751   5.054   37.104  1.00 28.22 ? 4   LEU H N   1 
ATOM   27   C CA  . LEU A 1 4   ? 2.625   5.656   36.393  1.00 27.86 ? 4   LEU H CA  1 
ATOM   28   C C   . LEU A 1 4   ? 1.473   5.751   37.382  1.00 27.15 ? 4   LEU H C   1 
ATOM   29   O O   . LEU A 1 4   ? 1.029   4.722   37.895  1.00 31.16 ? 4   LEU H O   1 
ATOM   30   C CB  . LEU A 1 4   ? 2.221   4.828   35.162  1.00 25.70 ? 4   LEU H CB  1 
ATOM   31   C CG  . LEU A 1 4   ? 3.075   4.863   33.879  1.00 31.60 ? 4   LEU H CG  1 
ATOM   32   C CD1 . LEU A 1 4   ? 4.502   4.472   34.120  1.00 27.07 ? 4   LEU H CD1 1 
ATOM   33   C CD2 . LEU A 1 4   ? 2.500   3.989   32.753  1.00 30.25 ? 4   LEU H CD2 1 
ATOM   34   N N   . VAL A 1 5   ? 0.974   6.963   37.631  1.00 25.00 ? 5   VAL H N   1 
ATOM   35   C CA  . VAL A 1 5   ? -0.061  7.202   38.642  1.00 25.36 ? 5   VAL H CA  1 
ATOM   36   C C   . VAL A 1 5   ? -1.263  7.871   37.998  1.00 27.43 ? 5   VAL H C   1 
ATOM   37   O O   . VAL A 1 5   ? -1.165  9.006   37.527  1.00 30.28 ? 5   VAL H O   1 
ATOM   38   C CB  . VAL A 1 5   ? 0.460   8.064   39.798  1.00 31.25 ? 5   VAL H CB  1 
ATOM   39   C CG1 . VAL A 1 5   ? -0.673  8.379   40.766  1.00 26.86 ? 5   VAL H CG1 1 
ATOM   40   C CG2 . VAL A 1 5   ? 1.630   7.362   40.492  1.00 27.89 ? 5   VAL H CG2 1 
ATOM   41   N N   . GLN A 1 6   ? -2.413  7.207   38.052  1.00 28.69 ? 6   GLN H N   1 
ATOM   42   C CA  . GLN A 1 6   ? -3.612  7.689   37.385  1.00 24.27 ? 6   GLN H CA  1 
ATOM   43   C C   . GLN A 1 6   ? -4.537  8.413   38.358  1.00 25.90 ? 6   GLN H C   1 
ATOM   44   O O   . GLN A 1 6   ? -4.482  8.214   39.569  1.00 29.74 ? 6   GLN H O   1 
ATOM   45   C CB  . GLN A 1 6   ? -4.357  6.530   36.728  1.00 25.79 ? 6   GLN H CB  1 
ATOM   46   C CG  . GLN A 1 6   ? -3.513  5.746   35.751  1.00 23.68 ? 6   GLN H CG  1 
ATOM   47   C CD  . GLN A 1 6   ? -4.279  4.614   35.121  1.00 25.99 ? 6   GLN H CD  1 
ATOM   48   O OE1 . GLN A 1 6   ? -3.717  3.536   34.848  1.00 27.87 ? 6   GLN H OE1 1 
ATOM   49   N NE2 . GLN A 1 6   ? -5.573  4.826   34.907  1.00 22.80 ? 6   GLN H NE2 1 
ATOM   50   N N   . SER A 1 7   ? -5.408  9.244   37.800  1.00 23.69 ? 7   SER H N   1 
ATOM   51   C CA  . SER A 1 7   ? -6.416  9.968   38.570  1.00 30.30 ? 7   SER H CA  1 
ATOM   52   C C   . SER A 1 7   ? -7.483  9.004   39.109  1.00 26.35 ? 7   SER H C   1 
ATOM   53   O O   . SER A 1 7   ? -7.573  7.847   38.702  1.00 27.52 ? 7   SER H O   1 
ATOM   54   C CB  . SER A 1 7   ? -7.067  11.060  37.709  1.00 26.58 ? 7   SER H CB  1 
ATOM   55   O OG  . SER A 1 7   ? -7.511  10.533  36.479  1.00 27.31 ? 7   SER H OG  1 
ATOM   56   N N   . GLY A 1 8   ? -8.305  9.510   40.030  1.00 23.02 ? 8   GLY H N   1 
ATOM   57   C CA  . GLY A 1 8   ? -9.238  8.691   40.777  1.00 24.51 ? 8   GLY H CA  1 
ATOM   58   C C   . GLY A 1 8   ? -10.441 8.271   39.965  1.00 30.29 ? 8   GLY H C   1 
ATOM   59   O O   . GLY A 1 8   ? -10.619 8.664   38.809  1.00 28.97 ? 8   GLY H O   1 
ATOM   60   N N   . ALA A 1 9   ? -11.285 7.451   40.606  1.00 28.82 ? 9   ALA H N   1 
ATOM   61   C CA  . ALA A 1 9   ? -12.472 6.886   39.968  1.00 25.06 ? 9   ALA H CA  1 
ATOM   62   C C   . ALA A 1 9   ? -13.419 7.985   39.507  1.00 26.83 ? 9   ALA H C   1 
ATOM   63   O O   . ALA A 1 9   ? -13.454 9.075   40.073  1.00 28.69 ? 9   ALA H O   1 
ATOM   64   C CB  . ALA A 1 9   ? -13.208 5.947   40.937  1.00 25.16 ? 9   ALA H CB  1 
ATOM   65   N N   . GLU A 1 10  ? -14.196 7.691   38.459  1.00 28.20 ? 10  GLU H N   1 
ATOM   66   C CA  . GLU A 1 10  ? -15.141 8.648   37.903  1.00 28.95 ? 10  GLU H CA  1 
ATOM   67   C C   . GLU A 1 10  ? -16.510 8.009   37.778  1.00 28.91 ? 10  GLU H C   1 
ATOM   68   O O   . GLU A 1 10  ? -16.633 6.807   37.523  1.00 24.60 ? 10  GLU H O   1 
ATOM   69   C CB  . GLU A 1 10  ? -14.711 9.143   36.518  1.00 32.24 ? 10  GLU H CB  1 
ATOM   70   C CG  . GLU A 1 10  ? -13.293 9.654   36.473  1.00 36.39 ? 10  GLU H CG  1 
ATOM   71   C CD  . GLU A 1 10  ? -13.248 11.159  36.436  1.00 34.82 ? 10  GLU H CD  1 
ATOM   72   O OE1 . GLU A 1 10  ? -12.135 11.694  36.319  1.00 29.48 ? 10  GLU H OE1 1 
ATOM   73   O OE2 . GLU A 1 10  ? -14.336 11.786  36.518  1.00 36.75 ? 10  GLU H OE2 1 
ATOM   74   N N   . VAL A 1 11  ? -17.538 8.826   37.956  1.00 26.23 ? 11  VAL H N   1 
ATOM   75   C CA  . VAL A 1 11  ? -18.912 8.416   37.730  1.00 28.63 ? 11  VAL H CA  1 
ATOM   76   C C   . VAL A 1 11  ? -19.524 9.403   36.733  1.00 27.77 ? 11  VAL H C   1 
ATOM   77   O O   . VAL A 1 11  ? -19.339 10.615  36.869  1.00 25.50 ? 11  VAL H O   1 
ATOM   78   C CB  . VAL A 1 11  ? -19.692 8.343   39.061  1.00 28.50 ? 11  VAL H CB  1 
ATOM   79   C CG1 . VAL A 1 11  ? -19.773 9.690   39.733  1.00 31.98 ? 11  VAL H CG1 1 
ATOM   80   C CG2 . VAL A 1 11  ? -21.057 7.838   38.825  1.00 30.63 ? 11  VAL H CG2 1 
ATOM   81   N N   . LYS A 1 12  ? -20.205 8.884   35.705  1.00 28.26 ? 12  LYS H N   1 
ATOM   82   C CA  . LYS A 1 12  ? -20.686 9.705   34.597  1.00 26.63 ? 12  LYS H CA  1 
ATOM   83   C C   . LYS A 1 12  ? -22.079 9.269   34.175  1.00 26.96 ? 12  LYS H C   1 
ATOM   84   O O   . LYS A 1 12  ? -22.428 8.088   34.245  1.00 27.76 ? 12  LYS H O   1 
ATOM   85   C CB  . LYS A 1 12  ? -19.747 9.635   33.373  1.00 25.58 ? 12  LYS H CB  1 
ATOM   86   C CG  . LYS A 1 12  ? -18.332 10.163  33.635  1.00 19.97 ? 12  LYS H CG  1 
ATOM   87   C CD  . LYS A 1 12  ? -18.410 11.691  33.891  1.00 27.99 ? 12  LYS H CD  1 
ATOM   88   C CE  . LYS A 1 12  ? -17.045 12.294  34.214  1.00 23.54 ? 12  LYS H CE  1 
ATOM   89   N NZ  . LYS A 1 12  ? -17.132 13.777  34.258  1.00 31.60 ? 12  LYS H NZ  1 
ATOM   90   N N   . LYS A 1 13  ? -22.870 10.236  33.719  1.00 25.20 ? 13  LYS H N   1 
ATOM   91   C CA  . LYS A 1 13  ? -24.142 9.942   33.078  1.00 28.31 ? 13  LYS H CA  1 
ATOM   92   C C   . LYS A 1 13  ? -23.929 9.678   31.586  1.00 24.73 ? 13  LYS H C   1 
ATOM   93   O O   . LYS A 1 13  ? -22.999 10.218  30.991  1.00 25.51 ? 13  LYS H O   1 
ATOM   94   C CB  . LYS A 1 13  ? -25.103 11.117  33.262  1.00 25.80 ? 13  LYS H CB  1 
ATOM   95   C CG  . LYS A 1 13  ? -25.460 11.435  34.713  1.00 33.85 ? 13  LYS H CG  1 
ATOM   96   C CD  . LYS A 1 13  ? -26.450 10.430  35.249  1.00 30.70 ? 13  LYS H CD  1 
ATOM   97   C CE  . LYS A 1 13  ? -27.216 10.969  36.438  1.00 29.49 ? 13  LYS H CE  1 
ATOM   98   N NZ  . LYS A 1 13  ? -26.392 11.087  37.636  1.00 30.84 ? 13  LYS H NZ  1 
ATOM   99   N N   . PRO A 1 14  ? -24.771 8.874   30.934  1.00 25.03 ? 14  PRO H N   1 
ATOM   100  C CA  . PRO A 1 14  ? -24.574 8.621   29.500  1.00 24.15 ? 14  PRO H CA  1 
ATOM   101  C C   . PRO A 1 14  ? -24.616 9.909   28.701  1.00 28.71 ? 14  PRO H C   1 
ATOM   102  O O   . PRO A 1 14  ? -25.373 10.825  29.016  1.00 24.64 ? 14  PRO H O   1 
ATOM   103  C CB  . PRO A 1 14  ? -25.742 7.696   29.124  1.00 25.78 ? 14  PRO H CB  1 
ATOM   104  C CG  . PRO A 1 14  ? -26.692 7.763   30.253  1.00 24.69 ? 14  PRO H CG  1 
ATOM   105  C CD  . PRO A 1 14  ? -25.939 8.159   31.470  1.00 25.13 ? 14  PRO H CD  1 
ATOM   106  N N   . GLY A 1 15  ? -23.788 9.966   27.655  1.00 24.25 ? 15  GLY H N   1 
ATOM   107  C CA  . GLY A 1 15  ? -23.611 11.155  26.867  1.00 22.25 ? 15  GLY H CA  1 
ATOM   108  C C   . GLY A 1 15  ? -22.567 12.105  27.406  1.00 28.84 ? 15  GLY H C   1 
ATOM   109  O O   . GLY A 1 15  ? -22.099 12.980  26.666  1.00 28.92 ? 15  GLY H O   1 
ATOM   110  N N   . ALA A 1 16  ? -22.162 11.939  28.663  1.00 23.87 ? 16  ALA H N   1 
ATOM   111  C CA  . ALA A 1 16  ? -21.124 12.785  29.206  1.00 22.71 ? 16  ALA H CA  1 
ATOM   112  C C   . ALA A 1 16  ? -19.775 12.386  28.618  1.00 25.83 ? 16  ALA H C   1 
ATOM   113  O O   . ALA A 1 16  ? -19.660 11.472  27.793  1.00 24.66 ? 16  ALA H O   1 
ATOM   114  C CB  . ALA A 1 16  ? -21.085 12.685  30.729  1.00 28.38 ? 16  ALA H CB  1 
ATOM   115  N N   . SER A 1 17  ? -18.733 13.068  29.069  1.00 25.46 ? 17  SER H N   1 
ATOM   116  C CA  . SER A 1 17  ? -17.385 12.655  28.739  1.00 26.03 ? 17  SER H CA  1 
ATOM   117  C C   . SER A 1 17  ? -16.566 12.576  30.016  1.00 25.27 ? 17  SER H C   1 
ATOM   118  O O   . SER A 1 17  ? -16.938 13.127  31.050  1.00 27.64 ? 17  SER H O   1 
ATOM   119  C CB  . SER A 1 17  ? -16.741 13.604  27.712  1.00 28.32 ? 17  SER H CB  1 
ATOM   120  O OG  . SER A 1 17  ? -16.175 14.699  28.370  1.00 36.20 ? 17  SER H OG  1 
ATOM   121  N N   . VAL A 1 18  ? -15.472 11.822  29.946  1.00 24.39 ? 18  VAL H N   1 
ATOM   122  C CA  . VAL A 1 18  ? -14.581 11.615  31.075  1.00 26.45 ? 18  VAL H CA  1 
ATOM   123  C C   . VAL A 1 18  ? -13.164 11.841  30.576  1.00 23.00 ? 18  VAL H C   1 
ATOM   124  O O   . VAL A 1 18  ? -12.849 11.562  29.419  1.00 26.04 ? 18  VAL H O   1 
ATOM   125  C CB  . VAL A 1 18  ? -14.739 10.198  31.688  1.00 24.57 ? 18  VAL H CB  1 
ATOM   126  C CG1 . VAL A 1 18  ? -14.348 9.114   30.681  1.00 20.66 ? 18  VAL H CG1 1 
ATOM   127  C CG2 . VAL A 1 18  ? -13.919 10.061  32.937  1.00 24.90 ? 18  VAL H CG2 1 
ATOM   128  N N   . LYS A 1 19  ? -12.311 12.375  31.447  1.00 24.74 ? 19  LYS H N   1 
ATOM   129  C CA  . LYS A 1 19  ? -10.902 12.591  31.142  1.00 26.94 ? 19  LYS H CA  1 
ATOM   130  C C   . LYS A 1 19  ? -10.078 12.007  32.280  1.00 25.29 ? 19  LYS H C   1 
ATOM   131  O O   . LYS A 1 19  ? -10.237 12.420  33.432  1.00 30.31 ? 19  LYS H O   1 
ATOM   132  C CB  . LYS A 1 19  ? -10.606 14.084  30.966  1.00 26.21 ? 19  LYS H CB  1 
ATOM   133  C CG  . LYS A 1 19  ? -9.194  14.416  30.475  1.00 26.46 ? 19  LYS H CG  1 
ATOM   134  C CD  . LYS A 1 19  ? -9.141  15.871  29.933  1.00 25.81 ? 19  LYS H CD  1 
ATOM   135  C CE  . LYS A 1 19  ? -7.773  16.202  29.350  1.00 36.56 ? 19  LYS H CE  1 
ATOM   136  N NZ  . LYS A 1 19  ? -7.714  17.600  28.815  1.00 39.79 ? 19  LYS H NZ  1 
ATOM   137  N N   . VAL A 1 20  ? -9.212  11.047  31.973  1.00 27.37 ? 20  VAL H N   1 
ATOM   138  C CA  . VAL A 1 20  ? -8.383  10.398  32.988  1.00 24.32 ? 20  VAL H CA  1 
ATOM   139  C C   . VAL A 1 20  ? -6.926  10.774  32.746  1.00 26.48 ? 20  VAL H C   1 
ATOM   140  O O   . VAL A 1 20  ? -6.473  10.874  31.595  1.00 25.98 ? 20  VAL H O   1 
ATOM   141  C CB  . VAL A 1 20  ? -8.591  8.864   33.031  1.00 28.08 ? 20  VAL H CB  1 
ATOM   142  C CG1 . VAL A 1 20  ? -10.068 8.528   33.105  1.00 25.49 ? 20  VAL H CG1 1 
ATOM   143  C CG2 . VAL A 1 20  ? -8.015  8.208   31.839  1.00 33.26 ? 20  VAL H CG2 1 
ATOM   144  N N   . SER A 1 21  ? -6.203  11.036  33.833  1.00 24.01 ? 21  SER H N   1 
ATOM   145  C CA  . SER A 1 21  ? -4.820  11.469  33.749  1.00 26.97 ? 21  SER H CA  1 
ATOM   146  C C   . SER A 1 21  ? -3.888  10.343  34.164  1.00 28.51 ? 21  SER H C   1 
ATOM   147  O O   . SER A 1 21  ? -4.261  9.456   34.940  1.00 28.00 ? 21  SER H O   1 
ATOM   148  C CB  . SER A 1 21  ? -4.571  12.695  34.632  1.00 27.37 ? 21  SER H CB  1 
ATOM   149  O OG  . SER A 1 21  ? -4.617  12.312  35.989  1.00 29.98 ? 21  SER H OG  1 
ATOM   150  N N   . CYS A 1 22  ? -2.668  10.388  33.638  1.00 24.50 ? 22  CYS H N   1 
ATOM   151  C CA  . CYS A 1 22  ? -1.634  9.393   33.940  1.00 26.57 ? 22  CYS H CA  1 
ATOM   152  C C   . CYS A 1 22  ? -0.325  10.155  34.144  1.00 32.88 ? 22  CYS H C   1 
ATOM   153  O O   . CYS A 1 22  ? 0.322   10.548  33.168  1.00 27.00 ? 22  CYS H O   1 
ATOM   154  C CB  . CYS A 1 22  ? -1.530  8.374   32.812  1.00 26.41 ? 22  CYS H CB  1 
ATOM   155  S SG  . CYS A 1 22  ? -0.210  7.126   32.904  1.00 29.15 ? 22  CYS H SG  1 
ATOM   156  N N   . LYS A 1 23  ? 0.045   10.373  35.413  1.00 32.02 ? 23  LYS H N   1 
ATOM   157  C CA  . LYS A 1 23  ? 1.247   11.113  35.785  1.00 27.23 ? 23  LYS H CA  1 
ATOM   158  C C   . LYS A 1 23  ? 2.407   10.144  35.977  1.00 32.91 ? 23  LYS H C   1 
ATOM   159  O O   . LYS A 1 23  ? 2.286   9.160   36.718  1.00 32.53 ? 23  LYS H O   1 
ATOM   160  C CB  . LYS A 1 23  ? 1.000   11.913  37.068  1.00 37.16 ? 23  LYS H CB  1 
ATOM   161  C CG  . LYS A 1 23  ? 2.276   12.547  37.657  1.00 39.51 ? 23  LYS H CG  1 
ATOM   162  C CD  . LYS A 1 23  ? 2.254   12.601  39.191  1.00 44.44 ? 23  LYS H CD  1 
ATOM   163  C CE  . LYS A 1 23  ? 3.563   12.044  39.795  1.00 43.50 ? 23  LYS H CE  1 
ATOM   164  N NZ  . LYS A 1 23  ? 3.521   11.934  41.297  1.00 49.13 ? 23  LYS H NZ  1 
ATOM   165  N N   . THR A 1 24  ? 3.518   10.400  35.293  1.00 28.46 ? 24  THR H N   1 
ATOM   166  C CA  . THR A 1 24  ? 4.619   9.456   35.286  1.00 34.04 ? 24  THR H CA  1 
ATOM   167  C C   . THR A 1 24  ? 5.846   10.070  35.947  1.00 34.42 ? 24  THR H C   1 
ATOM   168  O O   . THR A 1 24  ? 5.940   11.285  36.118  1.00 34.59 ? 24  THR H O   1 
ATOM   169  C CB  . THR A 1 24  ? 4.982   8.996   33.859  1.00 36.85 ? 24  THR H CB  1 
ATOM   170  O OG1 . THR A 1 24  ? 5.710   10.039  33.166  1.00 31.20 ? 24  THR H OG1 1 
ATOM   171  C CG2 . THR A 1 24  ? 3.719   8.595   33.084  1.00 32.13 ? 24  THR H CG2 1 
ATOM   172  N N   . SER A 1 25  ? 6.784   9.201   36.324  1.00 34.37 ? 25  SER H N   1 
ATOM   173  C CA  . SER A 1 25  ? 8.083   9.624   36.837  1.00 34.78 ? 25  SER H CA  1 
ATOM   174  C C   . SER A 1 25  ? 9.008   8.416   36.852  1.00 33.87 ? 25  SER H C   1 
ATOM   175  O O   . SER A 1 25  ? 8.593   7.277   36.607  1.00 35.28 ? 25  SER H O   1 
ATOM   176  C CB  . SER A 1 25  ? 7.982   10.244  38.230  1.00 34.63 ? 25  SER H CB  1 
ATOM   177  O OG  . SER A 1 25  ? 7.524   9.287   39.166  1.00 36.32 ? 25  SER H OG  1 
ATOM   178  N N   . GLY A 1 26  ? 10.270  8.681   37.151  1.00 35.12 ? 26  GLY H N   1 
ATOM   179  C CA  . GLY A 1 26  ? 11.278  7.650   37.134  1.00 32.46 ? 26  GLY H CA  1 
ATOM   180  C C   . GLY A 1 26  ? 11.847  7.348   35.774  1.00 35.16 ? 26  GLY H C   1 
ATOM   181  O O   . GLY A 1 26  ? 12.632  6.398   35.656  1.00 33.63 ? 26  GLY H O   1 
ATOM   182  N N   . TYR A 1 27  ? 11.460  8.093   34.734  1.00 34.43 ? 27  TYR H N   1 
ATOM   183  C CA  . TYR A 1 27  ? 11.989  7.843   33.400  1.00 30.24 ? 27  TYR H CA  1 
ATOM   184  C C   . TYR A 1 27  ? 11.793  9.081   32.531  1.00 33.92 ? 27  TYR H C   1 
ATOM   185  O O   . TYR A 1 27  ? 11.130  10.050  32.917  1.00 35.38 ? 27  TYR H O   1 
ATOM   186  C CB  . TYR A 1 27  ? 11.363  6.588   32.768  1.00 32.15 ? 27  TYR H CB  1 
ATOM   187  C CG  . TYR A 1 27  ? 9.920   6.680   32.279  1.00 36.28 ? 27  TYR H CG  1 
ATOM   188  C CD1 . TYR A 1 27  ? 8.838   6.540   33.164  1.00 32.58 ? 27  TYR H CD1 1 
ATOM   189  C CD2 . TYR A 1 27  ? 9.635   6.854   30.924  1.00 32.95 ? 27  TYR H CD2 1 
ATOM   190  C CE1 . TYR A 1 27  ? 7.510   6.597   32.708  1.00 32.99 ? 27  TYR H CE1 1 
ATOM   191  C CE2 . TYR A 1 27  ? 8.298   6.913   30.454  1.00 31.23 ? 27  TYR H CE2 1 
ATOM   192  C CZ  . TYR A 1 27  ? 7.247   6.782   31.353  1.00 33.97 ? 27  TYR H CZ  1 
ATOM   193  O OH  . TYR A 1 27  ? 5.948   6.842   30.904  1.00 36.51 ? 27  TYR H OH  1 
ATOM   194  N N   . THR A 1 28  ? 12.431  9.057   31.366  1.00 33.99 ? 28  THR H N   1 
ATOM   195  C CA  . THR A 1 28  ? 12.297  10.141  30.398  1.00 37.42 ? 28  THR H CA  1 
ATOM   196  C C   . THR A 1 28  ? 10.993  9.945   29.629  1.00 31.14 ? 28  THR H C   1 
ATOM   197  O O   . THR A 1 28  ? 10.893  9.057   28.775  1.00 29.01 ? 28  THR H O   1 
ATOM   198  C CB  . THR A 1 28  ? 13.497  10.172  29.456  1.00 36.35 ? 28  THR H CB  1 
ATOM   199  O OG1 . THR A 1 28  ? 14.683  10.451  30.207  1.00 40.11 ? 28  THR H OG1 1 
ATOM   200  C CG2 . THR A 1 28  ? 13.313  11.231  28.371  1.00 29.20 ? 28  THR H CG2 1 
ATOM   201  N N   . PHE A 1 29  ? 10.021  10.816  29.909  1.00 30.97 ? 29  PHE H N   1 
ATOM   202  C CA  . PHE A 1 29  ? 8.648   10.652  29.429  1.00 31.12 ? 29  PHE H CA  1 
ATOM   203  C C   . PHE A 1 29  ? 8.587   10.602  27.907  1.00 33.33 ? 29  PHE H C   1 
ATOM   204  O O   . PHE A 1 29  ? 7.870   9.774   27.334  1.00 30.72 ? 29  PHE H O   1 
ATOM   205  C CB  . PHE A 1 29  ? 7.796   11.801  29.981  1.00 32.75 ? 29  PHE H CB  1 
ATOM   206  C CG  . PHE A 1 29  ? 6.340   11.776  29.566  1.00 37.37 ? 29  PHE H CG  1 
ATOM   207  C CD1 . PHE A 1 29  ? 5.496   10.758  29.980  1.00 33.09 ? 29  PHE H CD1 1 
ATOM   208  C CD2 . PHE A 1 29  ? 5.798   12.830  28.827  1.00 32.98 ? 29  PHE H CD2 1 
ATOM   209  C CE1 . PHE A 1 29  ? 4.150   10.769  29.625  1.00 31.79 ? 29  PHE H CE1 1 
ATOM   210  C CE2 . PHE A 1 29  ? 4.449   12.843  28.473  1.00 33.50 ? 29  PHE H CE2 1 
ATOM   211  C CZ  . PHE A 1 29  ? 3.633   11.815  28.860  1.00 26.54 ? 29  PHE H CZ  1 
ATOM   212  N N   . THR A 1 30  ? 9.365   11.447  27.236  1.00 34.10 ? 30  THR H N   1 
ATOM   213  C CA  . THR A 1 30  ? 9.363   11.513  25.779  1.00 32.84 ? 30  THR H CA  1 
ATOM   214  C C   . THR A 1 30  ? 10.120  10.379  25.084  1.00 32.30 ? 30  THR H C   1 
ATOM   215  O O   . THR A 1 30  ? 10.074  10.302  23.850  1.00 34.53 ? 30  THR H O   1 
ATOM   216  C CB  . THR A 1 30  ? 9.930   12.867  25.327  1.00 36.98 ? 30  THR H CB  1 
ATOM   217  O OG1 . THR A 1 30  ? 11.087  13.187  26.114  1.00 40.95 ? 30  THR H OG1 1 
ATOM   218  C CG2 . THR A 1 30  ? 8.903   13.960  25.516  1.00 31.69 ? 30  THR H CG2 1 
ATOM   219  N N   . ASP A 1 31  ? 10.807  9.500   25.808  1.00 29.70 ? 31  ASP H N   1 
ATOM   220  C CA  . ASP A 1 31  ? 11.528  8.400   25.170  1.00 32.59 ? 31  ASP H CA  1 
ATOM   221  C C   . ASP A 1 31  ? 10.686  7.146   24.931  1.00 32.28 ? 31  ASP H C   1 
ATOM   222  O O   . ASP A 1 31  ? 11.171  6.206   24.293  1.00 31.02 ? 31  ASP H O   1 
ATOM   223  C CB  . ASP A 1 31  ? 12.754  8.007   26.010  1.00 36.14 ? 31  ASP H CB  1 
ATOM   224  C CG  . ASP A 1 31  ? 13.985  8.877   25.725  1.00 41.62 ? 31  ASP H CG  1 
ATOM   225  O OD1 . ASP A 1 31  ? 13.855  9.979   25.138  1.00 36.84 ? 31  ASP H OD1 1 
ATOM   226  O OD2 . ASP A 1 31  ? 15.090  8.447   26.118  1.00 43.33 ? 31  ASP H OD2 1 
ATOM   227  N N   . PHE A 1 32  ? 9.450   7.095   25.415  1.00 30.21 ? 32  PHE H N   1 
ATOM   228  C CA  . PHE A 1 32  ? 8.623   5.903   25.327  1.00 28.29 ? 32  PHE H CA  1 
ATOM   229  C C   . PHE A 1 32  ? 7.246   6.299   24.815  1.00 29.48 ? 32  PHE H C   1 
ATOM   230  O O   . PHE A 1 32  ? 6.792   7.412   25.070  1.00 28.29 ? 32  PHE H O   1 
ATOM   231  C CB  . PHE A 1 32  ? 8.452   5.245   26.701  1.00 29.49 ? 32  PHE H CB  1 
ATOM   232  C CG  . PHE A 1 32  ? 9.733   4.736   27.302  1.00 30.82 ? 32  PHE H CG  1 
ATOM   233  C CD1 . PHE A 1 32  ? 10.588  5.591   27.972  1.00 30.74 ? 32  PHE H CD1 1 
ATOM   234  C CD2 . PHE A 1 32  ? 10.064  3.395   27.214  1.00 32.60 ? 32  PHE H CD2 1 
ATOM   235  C CE1 . PHE A 1 32  ? 11.767  5.118   28.532  1.00 34.21 ? 32  PHE H CE1 1 
ATOM   236  C CE2 . PHE A 1 32  ? 11.249  2.914   27.769  1.00 34.64 ? 32  PHE H CE2 1 
ATOM   237  C CZ  . PHE A 1 32  ? 12.096  3.780   28.424  1.00 34.01 ? 32  PHE H CZ  1 
ATOM   238  N N   . TYR A 1 33  ? 6.572   5.385   24.118  1.00 25.55 ? 33  TYR H N   1 
ATOM   239  C CA  . TYR A 1 33  ? 5.179   5.659   23.791  1.00 24.15 ? 33  TYR H CA  1 
ATOM   240  C C   . TYR A 1 33  ? 4.292   5.335   24.988  1.00 28.18 ? 33  TYR H C   1 
ATOM   241  O O   . TYR A 1 33  ? 4.639   4.526   25.847  1.00 24.99 ? 33  TYR H O   1 
ATOM   242  C CB  . TYR A 1 33  ? 4.716   4.852   22.578  1.00 27.46 ? 33  TYR H CB  1 
ATOM   243  C CG  . TYR A 1 33  ? 5.004   5.500   21.241  1.00 25.76 ? 33  TYR H CG  1 
ATOM   244  C CD1 . TYR A 1 33  ? 5.948   6.516   21.126  1.00 23.69 ? 33  TYR H CD1 1 
ATOM   245  C CD2 . TYR A 1 33  ? 4.321   5.098   20.089  1.00 25.35 ? 33  TYR H CD2 1 
ATOM   246  C CE1 . TYR A 1 33  ? 6.212   7.106   19.898  1.00 27.63 ? 33  TYR H CE1 1 
ATOM   247  C CE2 . TYR A 1 33  ? 4.578   5.683   18.851  1.00 23.78 ? 33  TYR H CE2 1 
ATOM   248  C CZ  . TYR A 1 33  ? 5.513   6.694   18.767  1.00 24.04 ? 33  TYR H CZ  1 
ATOM   249  O OH  . TYR A 1 33  ? 5.787   7.272   17.549  1.00 23.27 ? 33  TYR H OH  1 
ATOM   250  N N   . MET A 1 34  ? 3.133   5.977   25.036  1.00 28.26 ? 34  MET H N   1 
ATOM   251  C CA  . MET A 1 34  ? 2.126   5.694   26.043  1.00 23.74 ? 34  MET H CA  1 
ATOM   252  C C   . MET A 1 34  ? 0.903   5.113   25.348  1.00 29.01 ? 34  MET H C   1 
ATOM   253  O O   . MET A 1 34  ? 0.458   5.641   24.315  1.00 26.69 ? 34  MET H O   1 
ATOM   254  C CB  . MET A 1 34  ? 1.765   6.953   26.821  1.00 19.66 ? 34  MET H CB  1 
ATOM   255  C CG  . MET A 1 34  ? 0.858   6.686   27.990  1.00 25.47 ? 34  MET H CG  1 
ATOM   256  S SD  . MET A 1 34  ? 1.646   5.689   29.294  1.00 32.46 ? 34  MET H SD  1 
ATOM   257  C CE  . MET A 1 34  ? 2.651   6.954   30.067  1.00 33.43 ? 34  MET H CE  1 
ATOM   258  N N   . HIS A 1 35  ? 0.385   4.015   25.887  1.00 22.26 ? 35  HIS H N   1 
ATOM   259  C CA  . HIS A 1 35  ? -0.824  3.378   25.384  1.00 21.52 ? 35  HIS H CA  1 
ATOM   260  C C   . HIS A 1 35  ? -1.910  3.427   26.451  1.00 24.11 ? 35  HIS H C   1 
ATOM   261  O O   . HIS A 1 35  ? -1.632  3.556   27.652  1.00 23.43 ? 35  HIS H O   1 
ATOM   262  C CB  . HIS A 1 35  ? -0.579  1.921   24.963  1.00 17.43 ? 35  HIS H CB  1 
ATOM   263  C CG  . HIS A 1 35  ? 0.534   1.749   23.970  1.00 25.12 ? 35  HIS H CG  1 
ATOM   264  N ND1 . HIS A 1 35  ? 0.308   1.459   22.640  1.00 24.21 ? 35  HIS H ND1 1 
ATOM   265  C CD2 . HIS A 1 35  ? 1.880   1.836   24.111  1.00 20.51 ? 35  HIS H CD2 1 
ATOM   266  C CE1 . HIS A 1 35  ? 1.465   1.351   22.010  1.00 23.36 ? 35  HIS H CE1 1 
ATOM   267  N NE2 . HIS A 1 35  ? 2.437   1.568   22.881  1.00 22.14 ? 35  HIS H NE2 1 
ATOM   268  N N   . TRP A 1 36  ? -3.163  3.350   25.995  1.00 22.20 ? 36  TRP H N   1 
ATOM   269  C CA  . TRP A 1 36  ? -4.306  3.238   26.886  1.00 21.49 ? 36  TRP H CA  1 
ATOM   270  C C   . TRP A 1 36  ? -5.075  1.960   26.580  1.00 21.30 ? 36  TRP H C   1 
ATOM   271  O O   . TRP A 1 36  ? -5.290  1.607   25.415  1.00 19.33 ? 36  TRP H O   1 
ATOM   272  C CB  . TRP A 1 36  ? -5.240  4.448   26.785  1.00 19.97 ? 36  TRP H CB  1 
ATOM   273  C CG  . TRP A 1 36  ? -4.618  5.714   27.280  1.00 24.36 ? 36  TRP H CG  1 
ATOM   274  C CD1 . TRP A 1 36  ? -3.827  6.592   26.571  1.00 22.90 ? 36  TRP H CD1 1 
ATOM   275  C CD2 . TRP A 1 36  ? -4.735  6.248   28.595  1.00 23.22 ? 36  TRP H CD2 1 
ATOM   276  N NE1 . TRP A 1 36  ? -3.458  7.651   27.381  1.00 22.86 ? 36  TRP H NE1 1 
ATOM   277  C CE2 . TRP A 1 36  ? -3.997  7.455   28.631  1.00 28.59 ? 36  TRP H CE2 1 
ATOM   278  C CE3 . TRP A 1 36  ? -5.387  5.821   29.756  1.00 18.47 ? 36  TRP H CE3 1 
ATOM   279  C CZ2 . TRP A 1 36  ? -3.927  8.251   29.780  1.00 26.03 ? 36  TRP H CZ2 1 
ATOM   280  C CZ3 . TRP A 1 36  ? -5.288  6.596   30.897  1.00 22.02 ? 36  TRP H CZ3 1 
ATOM   281  C CH2 . TRP A 1 36  ? -4.572  7.799   30.903  1.00 21.06 ? 36  TRP H CH2 1 
ATOM   282  N N   . MET A 1 37  ? -5.466  1.265   27.648  1.00 20.83 ? 37  MET H N   1 
ATOM   283  C CA  . MET A 1 37  ? -6.209  0.018   27.580  1.00 21.28 ? 37  MET H CA  1 
ATOM   284  C C   . MET A 1 37  ? -7.410  0.153   28.498  1.00 21.64 ? 37  MET H C   1 
ATOM   285  O O   . MET A 1 37  ? -7.423  0.983   29.411  1.00 22.18 ? 37  MET H O   1 
ATOM   286  C CB  . MET A 1 37  ? -5.386  -1.205  28.052  1.00 21.35 ? 37  MET H CB  1 
ATOM   287  C CG  . MET A 1 37  ? -4.663  -1.996  26.970  1.00 20.72 ? 37  MET H CG  1 
ATOM   288  S SD  . MET A 1 37  ? -3.313  -1.024  26.318  1.00 27.75 ? 37  MET H SD  1 
ATOM   289  C CE  . MET A 1 37  ? -2.480  -0.532  27.834  1.00 22.73 ? 37  MET H CE  1 
ATOM   290  N N   . ARG A 1 38  ? -8.417  -0.678  28.275  1.00 18.42 ? 38  ARG H N   1 
ATOM   291  C CA  . ARG A 1 38  ? -9.496  -0.735  29.243  1.00 22.99 ? 38  ARG H CA  1 
ATOM   292  C C   . ARG A 1 38  ? -9.953  -2.166  29.381  1.00 24.03 ? 38  ARG H C   1 
ATOM   293  O O   . ARG A 1 38  ? -9.634  -3.036  28.559  1.00 20.08 ? 38  ARG H O   1 
ATOM   294  C CB  . ARG A 1 38  ? -10.685 0.142   28.860  1.00 19.96 ? 38  ARG H CB  1 
ATOM   295  C CG  . ARG A 1 38  ? -11.401 -0.335  27.633  1.00 22.59 ? 38  ARG H CG  1 
ATOM   296  C CD  . ARG A 1 38  ? -12.619 0.525   27.395  1.00 16.37 ? 38  ARG H CD  1 
ATOM   297  N NE  . ARG A 1 38  ? -13.540 -0.037  26.419  1.00 24.77 ? 38  ARG H NE  1 
ATOM   298  C CZ  . ARG A 1 38  ? -14.645 0.585   26.036  1.00 20.72 ? 38  ARG H CZ  1 
ATOM   299  N NH1 . ARG A 1 38  ? -14.954 1.771   26.514  1.00 21.60 ? 38  ARG H NH1 1 
ATOM   300  N NH2 . ARG A 1 38  ? -15.448 0.005   25.149  1.00 23.54 ? 38  ARG H NH2 1 
ATOM   301  N N   . GLN A 1 39  ? -10.748 -2.381  30.425  1.00 21.42 ? 39  GLN H N   1 
ATOM   302  C CA  . GLN A 1 39  ? -11.211 -3.718  30.764  1.00 27.55 ? 39  GLN H CA  1 
ATOM   303  C C   . GLN A 1 39  ? -12.593 -3.559  31.366  1.00 24.71 ? 39  GLN H C   1 
ATOM   304  O O   . GLN A 1 39  ? -12.719 -3.024  32.469  1.00 21.77 ? 39  GLN H O   1 
ATOM   305  C CB  . GLN A 1 39  ? -10.261 -4.381  31.750  1.00 24.16 ? 39  GLN H CB  1 
ATOM   306  C CG  . GLN A 1 39  ? -10.587 -5.813  32.085  1.00 31.50 ? 39  GLN H CG  1 
ATOM   307  C CD  . GLN A 1 39  ? -9.413  -6.469  32.792  1.00 27.81 ? 39  GLN H CD  1 
ATOM   308  O OE1 . GLN A 1 39  ? -8.672  -5.801  33.512  1.00 30.71 ? 39  GLN H OE1 1 
ATOM   309  N NE2 . GLN A 1 39  ? -9.229  -7.767  32.572  1.00 26.05 ? 39  GLN H NE2 1 
ATOM   310  N N   . ALA A 1 40  ? -13.614 -3.981  30.631  1.00 24.73 ? 40  ALA H N   1 
ATOM   311  C CA  . ALA A 1 40  ? -14.952 -4.016  31.184  1.00 30.04 ? 40  ALA H CA  1 
ATOM   312  C C   . ALA A 1 40  ? -14.991 -5.031  32.330  1.00 31.83 ? 40  ALA H C   1 
ATOM   313  O O   . ALA A 1 40  ? -14.194 -5.975  32.360  1.00 32.07 ? 40  ALA H O   1 
ATOM   314  C CB  . ALA A 1 40  ? -15.959 -4.377  30.093  1.00 31.04 ? 40  ALA H CB  1 
ATOM   315  N N   . PRO A 1 41  ? -15.861 -4.840  33.318  1.00 36.69 ? 41  PRO H N   1 
ATOM   316  C CA  . PRO A 1 41  ? -15.798 -5.706  34.506  1.00 38.21 ? 41  PRO H CA  1 
ATOM   317  C C   . PRO A 1 41  ? -15.973 -7.172  34.114  1.00 35.13 ? 41  PRO H C   1 
ATOM   318  O O   . PRO A 1 41  ? -16.819 -7.520  33.286  1.00 33.68 ? 41  PRO H O   1 
ATOM   319  C CB  . PRO A 1 41  ? -16.945 -5.193  35.386  1.00 44.42 ? 41  PRO H CB  1 
ATOM   320  C CG  . PRO A 1 41  ? -17.254 -3.792  34.865  1.00 42.81 ? 41  PRO H CG  1 
ATOM   321  C CD  . PRO A 1 41  ? -16.983 -3.883  33.384  1.00 34.89 ? 41  PRO H CD  1 
ATOM   322  N N   . GLY A 1 42  ? -15.104 -8.021  34.655  1.00 39.01 ? 42  GLY H N   1 
ATOM   323  C CA  . GLY A 1 42  ? -15.122 -9.431  34.319  1.00 37.50 ? 42  GLY H CA  1 
ATOM   324  C C   . GLY A 1 42  ? -14.696 -9.780  32.909  1.00 43.69 ? 42  GLY H C   1 
ATOM   325  O O   . GLY A 1 42  ? -14.739 -10.961 32.543  1.00 45.89 ? 42  GLY H O   1 
ATOM   326  N N   . GLN A 1 43  ? -14.267 -8.813  32.107  1.00 39.47 ? 43  GLN H N   1 
ATOM   327  C CA  . GLN A 1 43  ? -13.969 -9.055  30.704  1.00 36.82 ? 43  GLN H CA  1 
ATOM   328  C C   . GLN A 1 43  ? -12.463 -8.933  30.445  1.00 31.79 ? 43  GLN H C   1 
ATOM   329  O O   . GLN A 1 43  ? -11.661 -8.762  31.367  1.00 31.45 ? 43  GLN H O   1 
ATOM   330  C CB  . GLN A 1 43  ? -14.777 -8.089  29.838  1.00 39.76 ? 43  GLN H CB  1 
ATOM   331  C CG  . GLN A 1 43  ? -16.278 -8.305  29.866  1.00 44.19 ? 43  GLN H CG  1 
ATOM   332  C CD  . GLN A 1 43  ? -16.769 -8.861  28.554  1.00 55.16 ? 43  GLN H CD  1 
ATOM   333  O OE1 . GLN A 1 43  ? -16.968 -8.116  27.586  1.00 60.67 ? 43  GLN H OE1 1 
ATOM   334  N NE2 . GLN A 1 43  ? -16.936 -10.183 28.496  1.00 55.94 ? 43  GLN H NE2 1 
ATOM   335  N N   . GLY A 1 44  ? -12.076 -9.030  29.168  1.00 29.43 ? 44  GLY H N   1 
ATOM   336  C CA  . GLY A 1 44  ? -10.679 -9.012  28.791  1.00 27.34 ? 44  GLY H CA  1 
ATOM   337  C C   . GLY A 1 44  ? -10.129 -7.607  28.554  1.00 27.05 ? 44  GLY H C   1 
ATOM   338  O O   . GLY A 1 44  ? -10.795 -6.588  28.721  1.00 26.23 ? 44  GLY H O   1 
ATOM   339  N N   . LEU A 1 45  ? -8.873  -7.566  28.143  1.00 27.32 ? 45  LEU H N   1 
ATOM   340  C CA  . LEU A 1 45  ? -8.197  -6.300  27.897  1.00 22.37 ? 45  LEU H CA  1 
ATOM   341  C C   . LEU A 1 45  ? -8.414  -5.886  26.450  1.00 21.52 ? 45  LEU H C   1 
ATOM   342  O O   . LEU A 1 45  ? -8.449  -6.733  25.556  1.00 22.60 ? 45  LEU H O   1 
ATOM   343  C CB  . LEU A 1 45  ? -6.705  -6.444  28.182  1.00 22.11 ? 45  LEU H CB  1 
ATOM   344  C CG  . LEU A 1 45  ? -6.287  -6.690  29.637  1.00 25.49 ? 45  LEU H CG  1 
ATOM   345  C CD1 . LEU A 1 45  ? -4.836  -7.158  29.668  1.00 27.20 ? 45  LEU H CD1 1 
ATOM   346  C CD2 . LEU A 1 45  ? -6.406  -5.402  30.441  1.00 28.27 ? 45  LEU H CD2 1 
ATOM   347  N N   . GLU A 1 46  ? -8.577  -4.587  26.215  1.00 24.58 ? 46  GLU H N   1 
ATOM   348  C CA  . GLU A 1 46  ? -8.524  -4.119  24.835  1.00 23.85 ? 46  GLU H CA  1 
ATOM   349  C C   . GLU A 1 46  ? -7.754  -2.812  24.744  1.00 27.21 ? 46  GLU H C   1 
ATOM   350  O O   . GLU A 1 46  ? -7.862  -1.943  25.620  1.00 21.57 ? 46  GLU H O   1 
ATOM   351  C CB  . GLU A 1 46  ? -9.914  -3.958  24.210  1.00 27.92 ? 46  GLU H CB  1 
ATOM   352  C CG  . GLU A 1 46  ? -10.751 -2.849  24.744  1.00 33.74 ? 46  GLU H CG  1 
ATOM   353  C CD  . GLU A 1 46  ? -12.123 -2.780  24.050  1.00 35.46 ? 46  GLU H CD  1 
ATOM   354  O OE1 . GLU A 1 46  ? -12.209 -3.119  22.843  1.00 33.60 ? 46  GLU H OE1 1 
ATOM   355  O OE2 . GLU A 1 46  ? -13.093 -2.389  24.727  1.00 32.32 ? 46  GLU H OE2 1 
ATOM   356  N N   . TRP A 1 47  ? -6.979  -2.697  23.661  1.00 20.73 ? 47  TRP H N   1 
ATOM   357  C CA  . TRP A 1 47  ? -6.165  -1.521  23.373  1.00 20.64 ? 47  TRP H CA  1 
ATOM   358  C C   . TRP A 1 47  ? -7.016  -0.398  22.774  1.00 22.24 ? 47  TRP H C   1 
ATOM   359  O O   . TRP A 1 47  ? -7.784  -0.632  21.839  1.00 22.44 ? 47  TRP H O   1 
ATOM   360  C CB  . TRP A 1 47  ? -5.059  -1.941  22.403  1.00 23.19 ? 47  TRP H CB  1 
ATOM   361  C CG  . TRP A 1 47  ? -4.141  -0.886  21.894  1.00 26.15 ? 47  TRP H CG  1 
ATOM   362  C CD1 . TRP A 1 47  ? -3.033  -0.372  22.525  1.00 24.07 ? 47  TRP H CD1 1 
ATOM   363  C CD2 . TRP A 1 47  ? -4.198  -0.266  20.609  1.00 21.16 ? 47  TRP H CD2 1 
ATOM   364  N NE1 . TRP A 1 47  ? -2.410  0.537   21.712  1.00 22.06 ? 47  TRP H NE1 1 
ATOM   365  C CE2 . TRP A 1 47  ? -3.102  0.628   20.530  1.00 24.56 ? 47  TRP H CE2 1 
ATOM   366  C CE3 . TRP A 1 47  ? -5.071  -0.370  19.521  1.00 20.33 ? 47  TRP H CE3 1 
ATOM   367  C CZ2 . TRP A 1 47  ? -2.861  1.421   19.405  1.00 24.60 ? 47  TRP H CZ2 1 
ATOM   368  C CZ3 . TRP A 1 47  ? -4.831  0.418   18.389  1.00 22.94 ? 47  TRP H CZ3 1 
ATOM   369  C CH2 . TRP A 1 47  ? -3.734  1.303   18.344  1.00 24.18 ? 47  TRP H CH2 1 
ATOM   370  N N   . MET A 1 48  ? -6.863  0.821   23.313  1.00 21.07 ? 48  MET H N   1 
ATOM   371  C CA  . MET A 1 48  ? -7.554  2.026   22.846  1.00 22.20 ? 48  MET H CA  1 
ATOM   372  C C   . MET A 1 48  ? -6.739  2.890   21.879  1.00 25.49 ? 48  MET H C   1 
ATOM   373  O O   . MET A 1 48  ? -7.334  3.547   21.011  1.00 22.06 ? 48  MET H O   1 
ATOM   374  C CB  . MET A 1 48  ? -7.960  2.896   24.045  1.00 19.81 ? 48  MET H CB  1 
ATOM   375  C CG  . MET A 1 48  ? -8.928  2.171   24.985  1.00 20.44 ? 48  MET H CG  1 
ATOM   376  S SD  . MET A 1 48  ? -9.497  3.292   26.232  1.00 24.72 ? 48  MET H SD  1 
ATOM   377  C CE  . MET A 1 48  ? -10.578 4.354   25.282  1.00 24.50 ? 48  MET H CE  1 
ATOM   378  N N   . GLY A 1 49  ? -5.419  2.948   22.037  1.00 22.03 ? 49  GLY H N   1 
ATOM   379  C CA  . GLY A 1 49  ? -4.559  3.711   21.143  1.00 23.11 ? 49  GLY H CA  1 
ATOM   380  C C   . GLY A 1 49  ? -3.263  4.089   21.825  1.00 22.64 ? 49  GLY H C   1 
ATOM   381  O O   . GLY A 1 49  ? -3.060  3.859   23.030  1.00 20.99 ? 49  GLY H O   1 
ATOM   382  N N   . TRP A 1 50  ? -2.366  4.684   21.035  1.00 21.85 ? 50  TRP H N   1 
ATOM   383  C CA  . TRP A 1 50  ? -1.113  5.194   21.569  1.00 20.59 ? 50  TRP H CA  1 
ATOM   384  C C   . TRP A 1 50  ? -0.965  6.683   21.288  1.00 21.69 ? 50  TRP H C   1 
ATOM   385  O O   . TRP A 1 50  ? -1.659  7.264   20.445  1.00 22.83 ? 50  TRP H O   1 
ATOM   386  C CB  . TRP A 1 50  ? 0.122   4.430   21.022  1.00 19.39 ? 50  TRP H CB  1 
ATOM   387  C CG  . TRP A 1 50  ? 0.341   4.308   19.520  1.00 21.37 ? 50  TRP H CG  1 
ATOM   388  C CD1 . TRP A 1 50  ? 0.194   3.177   18.765  1.00 22.42 ? 50  TRP H CD1 1 
ATOM   389  C CD2 . TRP A 1 50  ? 0.824   5.324   18.619  1.00 20.86 ? 50  TRP H CD2 1 
ATOM   390  N NE1 . TRP A 1 50  ? 0.500   3.435   17.447  1.00 24.40 ? 50  TRP H NE1 1 
ATOM   391  C CE2 . TRP A 1 50  ? 0.920   4.735   17.335  1.00 20.43 ? 50  TRP H CE2 1 
ATOM   392  C CE3 . TRP A 1 50  ? 1.159   6.674   18.769  1.00 21.49 ? 50  TRP H CE3 1 
ATOM   393  C CZ2 . TRP A 1 50  ? 1.333   5.455   16.208  1.00 24.58 ? 50  TRP H CZ2 1 
ATOM   394  C CZ3 . TRP A 1 50  ? 1.576   7.397   17.640  1.00 23.95 ? 50  TRP H CZ3 1 
ATOM   395  C CH2 . TRP A 1 50  ? 1.651   6.788   16.383  1.00 22.89 ? 50  TRP H CH2 1 
ATOM   396  N N   . ILE A 1 51  ? -0.066  7.304   22.028  1.00 21.48 ? 51  ILE H N   1 
ATOM   397  C CA  . ILE A 1 51  ? 0.297   8.694   21.799  1.00 21.28 ? 51  ILE H CA  1 
ATOM   398  C C   . ILE A 1 51  ? 1.809   8.802   21.781  1.00 27.81 ? 51  ILE H C   1 
ATOM   399  O O   . ILE A 1 51  ? 2.502   8.144   22.575  1.00 26.09 ? 51  ILE H O   1 
ATOM   400  C CB  . ILE A 1 51  ? -0.299  9.640   22.855  1.00 21.63 ? 51  ILE H CB  1 
ATOM   401  C CG1 . ILE A 1 51  ? 0.177   11.086  22.592  1.00 21.58 ? 51  ILE H CG1 1 
ATOM   402  C CG2 . ILE A 1 51  ? 0.049   9.168   24.258  1.00 23.72 ? 51  ILE H CG2 1 
ATOM   403  C CD1 . ILE A 1 51  ? -0.569  12.131  23.384  1.00 21.90 ? 51  ILE H CD1 1 
ATOM   404  N N   . ASN A 1 52  ? 2.314   9.611   20.843  1.00 24.59 ? 52  ASN H N   1 
ATOM   405  C CA  . ASN A 1 52  ? 3.720   9.968   20.745  1.00 27.27 ? 52  ASN H CA  1 
ATOM   406  C C   . ASN A 1 52  ? 3.950   11.164  21.657  1.00 26.48 ? 52  ASN H C   1 
ATOM   407  O O   . ASN A 1 52  ? 3.390   12.245  21.385  1.00 26.81 ? 52  ASN H O   1 
ATOM   408  C CB  . ASN A 1 52  ? 4.082   10.297  19.295  1.00 25.20 ? 52  ASN H CB  1 
ATOM   409  C CG  . ASN A 1 52  ? 5.556   10.759  19.119  1.00 24.18 ? 52  ASN H CG  1 
ATOM   410  O OD1 . ASN A 1 52  ? 5.963   11.795  19.642  1.00 30.58 ? 52  ASN H OD1 1 
ATOM   411  N ND2 . ASN A 1 52  ? 6.308   10.019  18.317  1.00 23.81 ? 52  ASN H ND2 1 
ATOM   412  N N   . PRO A 1 53  A 4.713   11.050  22.736  1.00 28.93 ? 52  PRO H N   1 
ATOM   413  C CA  . PRO A 1 53  A 4.810   12.172  23.683  1.00 27.99 ? 52  PRO H CA  1 
ATOM   414  C C   . PRO A 1 53  A 5.615   13.361  23.168  1.00 27.75 ? 52  PRO H C   1 
ATOM   415  O O   . PRO A 1 53  A 5.389   14.487  23.632  1.00 26.48 ? 52  PRO H O   1 
ATOM   416  C CB  . PRO A 1 53  A 5.466   11.542  24.920  1.00 32.28 ? 52  PRO H CB  1 
ATOM   417  C CG  . PRO A 1 53  A 6.247   10.407  24.370  1.00 32.33 ? 52  PRO H CG  1 
ATOM   418  C CD  . PRO A 1 53  A 5.429   9.850   23.220  1.00 31.59 ? 52  PRO H CD  1 
ATOM   419  N N   . THR A 1 54  ? 6.552   13.156  22.243  1.00 25.00 ? 53  THR H N   1 
ATOM   420  C CA  . THR A 1 54  ? 7.352   14.281  21.755  1.00 27.52 ? 53  THR H CA  1 
ATOM   421  C C   . THR A 1 54  ? 6.508   15.240  20.924  1.00 29.27 ? 53  THR H C   1 
ATOM   422  O O   . THR A 1 54  ? 6.563   16.463  21.111  1.00 26.40 ? 53  THR H O   1 
ATOM   423  C CB  . THR A 1 54  ? 8.530   13.777  20.922  1.00 28.90 ? 53  THR H CB  1 
ATOM   424  O OG1 . THR A 1 54  ? 9.473   13.110  21.774  1.00 28.31 ? 53  THR H OG1 1 
ATOM   425  C CG2 . THR A 1 54  ? 9.197   14.933  20.202  1.00 24.11 ? 53  THR H CG2 1 
ATOM   426  N N   . GLY A 1 55  ? 5.744   14.706  19.980  1.00 30.03 ? 54  GLY H N   1 
ATOM   427  C CA  . GLY A 1 55  ? 4.950   15.554  19.118  1.00 28.13 ? 54  GLY H CA  1 
ATOM   428  C C   . GLY A 1 55  ? 3.448   15.507  19.353  1.00 26.05 ? 54  GLY H C   1 
ATOM   429  O O   . GLY A 1 55  ? 2.719   16.347  18.817  1.00 22.97 ? 54  GLY H O   1 
ATOM   430  N N   . GLY A 1 56  ? 2.952   14.539  20.128  1.00 24.36 ? 55  GLY H N   1 
ATOM   431  C CA  . GLY A 1 56  ? 1.518   14.502  20.390  1.00 20.92 ? 55  GLY H CA  1 
ATOM   432  C C   . GLY A 1 56  ? 0.679   13.805  19.340  1.00 23.87 ? 55  GLY H C   1 
ATOM   433  O O   . GLY A 1 56  ? -0.543  13.669  19.531  1.00 23.07 ? 55  GLY H O   1 
ATOM   434  N N   . GLY A 1 57  ? 1.286   13.336  18.253  1.00 20.82 ? 56  GLY H N   1 
ATOM   435  C CA  . GLY A 1 57  ? 0.554   12.514  17.312  1.00 17.24 ? 56  GLY H CA  1 
ATOM   436  C C   . GLY A 1 57  ? 0.049   11.237  17.964  1.00 23.06 ? 56  GLY H C   1 
ATOM   437  O O   . GLY A 1 57  ? 0.586   10.769  18.980  1.00 19.84 ? 56  GLY H O   1 
ATOM   438  N N   . VAL A 1 58  ? -1.039  10.693  17.401  1.00 20.61 ? 57  VAL H N   1 
ATOM   439  C CA  . VAL A 1 58  ? -1.754  9.585   18.024  1.00 22.07 ? 57  VAL H CA  1 
ATOM   440  C C   . VAL A 1 58  ? -2.162  8.564   16.972  1.00 22.87 ? 57  VAL H C   1 
ATOM   441  O O   . VAL A 1 58  ? -2.225  8.854   15.775  1.00 18.90 ? 57  VAL H O   1 
ATOM   442  C CB  . VAL A 1 58  ? -2.994  10.068  18.793  1.00 19.64 ? 57  VAL H CB  1 
ATOM   443  C CG1 . VAL A 1 58  ? -2.583  10.867  20.030  1.00 19.16 ? 57  VAL H CG1 1 
ATOM   444  C CG2 . VAL A 1 58  ? -3.897  10.887  17.867  1.00 21.27 ? 57  VAL H CG2 1 
ATOM   445  N N   . ASN A 1 59  ? -2.436  7.345   17.437  1.00 19.23 ? 58  ASN H N   1 
ATOM   446  C CA  . ASN A 1 59  ? -3.061  6.318   16.604  1.00 20.03 ? 58  ASN H CA  1 
ATOM   447  C C   . ASN A 1 59  ? -4.099  5.630   17.475  1.00 26.21 ? 58  ASN H C   1 
ATOM   448  O O   . ASN A 1 59  ? -3.735  4.880   18.385  1.00 22.67 ? 58  ASN H O   1 
ATOM   449  C CB  . ASN A 1 59  ? -2.062  5.300   16.068  1.00 21.26 ? 58  ASN H CB  1 
ATOM   450  C CG  . ASN A 1 59  ? -2.646  4.428   14.975  1.00 21.39 ? 58  ASN H CG  1 
ATOM   451  O OD1 . ASN A 1 59  ? -3.847  4.491   14.674  1.00 22.25 ? 58  ASN H OD1 1 
ATOM   452  N ND2 . ASN A 1 59  ? -1.794  3.607   14.364  1.00 20.32 ? 58  ASN H ND2 1 
ATOM   453  N N   . TYR A 1 60  ? -5.375  5.907   17.206  1.00 24.09 ? 59  TYR H N   1 
ATOM   454  C CA  . TYR A 1 60  ? -6.495  5.371   17.973  1.00 23.96 ? 59  TYR H CA  1 
ATOM   455  C C   . TYR A 1 60  ? -6.967  4.058   17.363  1.00 24.95 ? 59  TYR H C   1 
ATOM   456  O O   . TYR A 1 60  ? -6.945  3.886   16.139  1.00 26.83 ? 59  TYR H O   1 
ATOM   457  C CB  . TYR A 1 60  ? -7.650  6.373   17.968  1.00 23.02 ? 59  TYR H CB  1 
ATOM   458  C CG  . TYR A 1 60  ? -7.299  7.704   18.576  1.00 26.75 ? 59  TYR H CG  1 
ATOM   459  C CD1 . TYR A 1 60  ? -6.518  7.764   19.726  1.00 20.61 ? 59  TYR H CD1 1 
ATOM   460  C CD2 . TYR A 1 60  ? -7.755  8.901   18.018  1.00 19.68 ? 59  TYR H CD2 1 
ATOM   461  C CE1 . TYR A 1 60  ? -6.184  8.955   20.299  1.00 22.03 ? 59  TYR H CE1 1 
ATOM   462  C CE2 . TYR A 1 60  ? -7.424  10.123  18.606  1.00 22.87 ? 59  TYR H CE2 1 
ATOM   463  C CZ  . TYR A 1 60  ? -6.642  10.136  19.741  1.00 22.53 ? 59  TYR H CZ  1 
ATOM   464  O OH  . TYR A 1 60  ? -6.298  11.306  20.356  1.00 21.33 ? 59  TYR H OH  1 
ATOM   465  N N   . ALA A 1 61  ? -7.393  3.126   18.216  1.00 25.94 ? 60  ALA H N   1 
ATOM   466  C CA  . ALA A 1 61  ? -8.088  1.951   17.715  1.00 19.30 ? 60  ALA H CA  1 
ATOM   467  C C   . ALA A 1 61  ? -9.321  2.402   16.934  1.00 20.57 ? 60  ALA H C   1 
ATOM   468  O O   . ALA A 1 61  ? -10.046 3.312   17.353  1.00 22.13 ? 60  ALA H O   1 
ATOM   469  C CB  . ALA A 1 61  ? -8.496  1.034   18.875  1.00 21.73 ? 60  ALA H CB  1 
ATOM   470  N N   . HIS A 1 62  ? -9.556  1.773   15.782  1.00 22.40 ? 61  HIS H N   1 
ATOM   471  C CA  . HIS A 1 62  ? -10.664 2.196   14.932  1.00 24.19 ? 61  HIS H CA  1 
ATOM   472  C C   . HIS A 1 62  ? -11.975 2.274   15.716  1.00 26.03 ? 61  HIS H C   1 
ATOM   473  O O   . HIS A 1 62  ? -12.784 3.180   15.505  1.00 21.52 ? 61  HIS H O   1 
ATOM   474  C CB  . HIS A 1 62  ? -10.810 1.237   13.759  1.00 25.89 ? 61  HIS H CB  1 
ATOM   475  C CG  . HIS A 1 62  ? -11.947 1.577   12.850  1.00 30.64 ? 61  HIS H CG  1 
ATOM   476  N ND1 . HIS A 1 62  ? -11.900 2.631   11.958  1.00 36.93 ? 61  HIS H ND1 1 
ATOM   477  C CD2 . HIS A 1 62  ? -13.169 1.013   12.702  1.00 35.86 ? 61  HIS H CD2 1 
ATOM   478  C CE1 . HIS A 1 62  ? -13.044 2.702   11.299  1.00 30.75 ? 61  HIS H CE1 1 
ATOM   479  N NE2 . HIS A 1 62  ? -13.826 1.722   11.721  1.00 36.95 ? 61  HIS H NE2 1 
ATOM   480  N N   . LYS A 1 63  ? -12.169 1.354   16.657  1.00 19.63 ? 62  LYS H N   1 
ATOM   481  C CA  . LYS A 1 63  ? -13.391 1.303   17.454  1.00 28.48 ? 62  LYS H CA  1 
ATOM   482  C C   . LYS A 1 63  ? -13.627 2.601   18.216  1.00 27.66 ? 62  LYS H C   1 
ATOM   483  O O   . LYS A 1 63  ? -14.778 3.014   18.404  1.00 25.98 ? 62  LYS H O   1 
ATOM   484  C CB  . LYS A 1 63  ? -13.285 0.101   18.409  1.00 27.31 ? 62  LYS H CB  1 
ATOM   485  C CG  . LYS A 1 63  ? -14.319 -0.030  19.491  1.00 37.58 ? 62  LYS H CG  1 
ATOM   486  C CD  . LYS A 1 63  ? -14.101 -1.367  20.224  1.00 35.29 ? 62  LYS H CD  1 
ATOM   487  C CE  . LYS A 1 63  ? -15.067 -1.537  21.375  1.00 39.65 ? 62  LYS H CE  1 
ATOM   488  N NZ  . LYS A 1 63  ? -14.696 -2.723  22.185  1.00 41.87 ? 62  LYS H NZ  1 
ATOM   489  N N   . PHE A 1 64  ? -12.558 3.255   18.673  1.00 23.56 ? 63  PHE H N   1 
ATOM   490  C CA  . PHE A 1 64  ? -12.677 4.494   19.429  1.00 24.22 ? 63  PHE H CA  1 
ATOM   491  C C   . PHE A 1 64  ? -12.424 5.751   18.604  1.00 22.62 ? 63  PHE H C   1 
ATOM   492  O O   . PHE A 1 64  ? -12.594 6.863   19.127  1.00 23.29 ? 63  PHE H O   1 
ATOM   493  C CB  . PHE A 1 64  ? -11.731 4.434   20.637  1.00 24.41 ? 63  PHE H CB  1 
ATOM   494  C CG  . PHE A 1 64  ? -11.981 3.240   21.512  1.00 22.36 ? 63  PHE H CG  1 
ATOM   495  C CD1 . PHE A 1 64  ? -13.062 3.231   22.369  1.00 25.77 ? 63  PHE H CD1 1 
ATOM   496  C CD2 . PHE A 1 64  ? -11.179 2.112   21.435  1.00 21.69 ? 63  PHE H CD2 1 
ATOM   497  C CE1 . PHE A 1 64  ? -13.324 2.110   23.175  1.00 32.53 ? 63  PHE H CE1 1 
ATOM   498  C CE2 . PHE A 1 64  ? -11.433 1.001   22.222  1.00 26.94 ? 63  PHE H CE2 1 
ATOM   499  C CZ  . PHE A 1 64  ? -12.508 0.994   23.097  1.00 25.07 ? 63  PHE H CZ  1 
ATOM   500  N N   . GLN A 1 65  ? -12.048 5.613   17.334  1.00 23.86 ? 64  GLN H N   1 
ATOM   501  C CA  . GLN A 1 65  ? -11.755 6.780   16.504  1.00 24.45 ? 64  GLN H CA  1 
ATOM   502  C C   . GLN A 1 65  ? -12.988 7.659   16.391  1.00 23.51 ? 64  GLN H C   1 
ATOM   503  O O   . GLN A 1 65  ? -14.036 7.204   15.934  1.00 31.70 ? 64  GLN H O   1 
ATOM   504  C CB  . GLN A 1 65  ? -11.306 6.347   15.103  1.00 26.74 ? 64  GLN H CB  1 
ATOM   505  C CG  . GLN A 1 65  ? -11.094 7.514   14.133  1.00 26.51 ? 64  GLN H CG  1 
ATOM   506  C CD  . GLN A 1 65  ? -9.919  8.377   14.536  1.00 26.05 ? 64  GLN H CD  1 
ATOM   507  O OE1 . GLN A 1 65  ? -8.836  7.859   14.802  1.00 25.16 ? 64  GLN H OE1 1 
ATOM   508  N NE2 . GLN A 1 65  ? -10.134 9.688   14.622  1.00 24.05 ? 64  GLN H NE2 1 
ATOM   509  N N   . GLY A 1 66  ? -12.861 8.923   16.758  1.00 23.13 ? 65  GLY H N   1 
ATOM   510  C CA  . GLY A 1 66  ? -13.976 9.845   16.685  1.00 27.71 ? 65  GLY H CA  1 
ATOM   511  C C   . GLY A 1 66  ? -14.582 10.195  18.024  1.00 30.54 ? 65  GLY H C   1 
ATOM   512  O O   . GLY A 1 66  ? -15.341 11.165  18.099  1.00 30.80 ? 65  GLY H O   1 
ATOM   513  N N   . ARG A 1 67  ? -14.279 9.463   19.091  1.00 27.48 ? 66  ARG H N   1 
ATOM   514  C CA  . ARG A 1 67  ? -14.705 9.948   20.393  1.00 29.02 ? 66  ARG H CA  1 
ATOM   515  C C   . ARG A 1 67  ? -13.672 9.797   21.495  1.00 27.42 ? 66  ARG H C   1 
ATOM   516  O O   . ARG A 1 67  ? -13.981 10.113  22.644  1.00 27.52 ? 66  ARG H O   1 
ATOM   517  C CB  . ARG A 1 67  ? -16.023 9.278   20.827  1.00 29.42 ? 66  ARG H CB  1 
ATOM   518  C CG  . ARG A 1 67  ? -16.041 7.813   20.800  1.00 26.38 ? 66  ARG H CG  1 
ATOM   519  C CD  . ARG A 1 67  ? -17.317 7.311   21.497  1.00 28.94 ? 66  ARG H CD  1 
ATOM   520  N NE  . ARG A 1 67  ? -17.163 5.919   21.899  1.00 26.73 ? 66  ARG H NE  1 
ATOM   521  C CZ  . ARG A 1 67  ? -17.276 5.481   23.143  1.00 24.26 ? 66  ARG H CZ  1 
ATOM   522  N NH1 . ARG A 1 67  ? -17.681 6.276   24.117  1.00 24.28 ? 66  ARG H NH1 1 
ATOM   523  N NH2 . ARG A 1 67  ? -16.983 4.210   23.415  1.00 20.97 ? 66  ARG H NH2 1 
ATOM   524  N N   . VAL A 1 68  ? -12.469 9.338   21.204  1.00 26.71 ? 67  VAL H N   1 
ATOM   525  C CA  . VAL A 1 68  ? -11.403 9.389   22.189  1.00 25.34 ? 67  VAL H CA  1 
ATOM   526  C C   . VAL A 1 68  ? -10.432 10.469  21.751  1.00 25.72 ? 67  VAL H C   1 
ATOM   527  O O   . VAL A 1 68  ? -10.230 10.700  20.553  1.00 28.00 ? 67  VAL H O   1 
ATOM   528  C CB  . VAL A 1 68  ? -10.680 8.038   22.371  1.00 24.56 ? 67  VAL H CB  1 
ATOM   529  C CG1 . VAL A 1 68  ? -9.844  7.690   21.121  1.00 23.73 ? 67  VAL H CG1 1 
ATOM   530  C CG2 . VAL A 1 68  ? -9.813  8.076   23.631  1.00 24.01 ? 67  VAL H CG2 1 
ATOM   531  N N   . THR A 1 69  ? -9.865  11.165  22.732  1.00 27.03 ? 68  THR H N   1 
ATOM   532  C CA  . THR A 1 69  ? -8.806  12.146  22.515  1.00 27.51 ? 68  THR H CA  1 
ATOM   533  C C   . THR A 1 69  ? -7.686  11.861  23.504  1.00 29.57 ? 68  THR H C   1 
ATOM   534  O O   . THR A 1 69  ? -7.911  11.938  24.718  1.00 25.78 ? 68  THR H O   1 
ATOM   535  C CB  . THR A 1 69  ? -9.320  13.576  22.719  1.00 29.35 ? 68  THR H CB  1 
ATOM   536  O OG1 . THR A 1 69  ? -10.403 13.837  21.823  1.00 30.93 ? 68  THR H OG1 1 
ATOM   537  C CG2 . THR A 1 69  ? -8.198  14.587  22.483  1.00 29.17 ? 68  THR H CG2 1 
ATOM   538  N N   . MET A 1 70  ? -6.482  11.551  22.992  1.00 26.14 ? 69  MET H N   1 
ATOM   539  C CA  . MET A 1 70  ? -5.290  11.391  23.819  1.00 23.37 ? 69  MET H CA  1 
ATOM   540  C C   . MET A 1 70  ? -4.400  12.618  23.659  1.00 28.02 ? 69  MET H C   1 
ATOM   541  O O   . MET A 1 70  ? -4.147  13.061  22.535  1.00 24.15 ? 69  MET H O   1 
ATOM   542  C CB  . MET A 1 70  ? -4.519  10.116  23.453  1.00 22.10 ? 69  MET H CB  1 
ATOM   543  C CG  . MET A 1 70  ? -5.360  8.850   23.670  1.00 20.46 ? 69  MET H CG  1 
ATOM   544  S SD  . MET A 1 70  ? -4.546  7.345   23.143  1.00 24.58 ? 69  MET H SD  1 
ATOM   545  C CE  . MET A 1 70  ? -5.862  6.150   23.454  1.00 17.76 ? 69  MET H CE  1 
ATOM   546  N N   . THR A 1 71  ? -3.927  13.155  24.781  1.00 25.59 ? 70  THR H N   1 
ATOM   547  C CA  . THR A 1 71  ? -3.061  14.326  24.822  1.00 26.38 ? 70  THR H CA  1 
ATOM   548  C C   . THR A 1 71  ? -2.000  14.100  25.897  1.00 30.52 ? 70  THR H C   1 
ATOM   549  O O   . THR A 1 71  ? -2.076  13.149  26.682  1.00 28.84 ? 70  THR H O   1 
ATOM   550  C CB  . THR A 1 71  ? -3.857  15.596  25.137  1.00 23.85 ? 70  THR H CB  1 
ATOM   551  O OG1 . THR A 1 71  ? -4.529  15.410  26.383  1.00 26.73 ? 70  THR H OG1 1 
ATOM   552  C CG2 . THR A 1 71  ? -4.916  15.892  24.059  1.00 25.96 ? 70  THR H CG2 1 
ATOM   553  N N   . ARG A 1 72  ? -1.006  14.983  25.945  1.00 26.63 ? 71  ARG H N   1 
ATOM   554  C CA  . ARG A 1 72  ? -0.001  14.916  27.005  1.00 28.83 ? 71  ARG H CA  1 
ATOM   555  C C   . ARG A 1 72  ? 0.526   16.314  27.288  1.00 32.69 ? 71  ARG H C   1 
ATOM   556  O O   . ARG A 1 72  ? 0.439   17.217  26.454  1.00 31.21 ? 71  ARG H O   1 
ATOM   557  C CB  . ARG A 1 72  ? 1.180   13.998  26.658  1.00 26.86 ? 71  ARG H CB  1 
ATOM   558  C CG  . ARG A 1 72  ? 2.295   14.690  25.842  1.00 28.63 ? 71  ARG H CG  1 
ATOM   559  C CD  . ARG A 1 72  ? 1.825   15.059  24.410  1.00 26.48 ? 71  ARG H CD  1 
ATOM   560  N NE  . ARG A 1 72  ? 2.905   15.677  23.644  1.00 27.23 ? 71  ARG H NE  1 
ATOM   561  C CZ  . ARG A 1 72  ? 2.803   16.811  22.968  1.00 29.24 ? 71  ARG H CZ  1 
ATOM   562  N NH1 . ARG A 1 72  ? 1.640   17.409  22.799  1.00 23.76 ? 71  ARG H NH1 1 
ATOM   563  N NH2 . ARG A 1 72  ? 3.899   17.348  22.428  1.00 23.48 ? 71  ARG H NH2 1 
ATOM   564  N N   . ASP A 1 73  ? 1.067   16.482  28.488  1.00 30.81 ? 72  ASP H N   1 
ATOM   565  C CA  . ASP A 1 73  ? 1.747   17.707  28.896  1.00 30.13 ? 72  ASP H CA  1 
ATOM   566  C C   . ASP A 1 73  ? 3.152   17.295  29.315  1.00 33.96 ? 72  ASP H C   1 
ATOM   567  O O   . ASP A 1 73  ? 3.350   16.858  30.455  1.00 34.65 ? 72  ASP H O   1 
ATOM   568  C CB  . ASP A 1 73  ? 0.993   18.396  30.026  1.00 26.81 ? 72  ASP H CB  1 
ATOM   569  C CG  . ASP A 1 73  ? 1.725   19.638  30.566  1.00 37.54 ? 72  ASP H CG  1 
ATOM   570  O OD1 . ASP A 1 73  ? 2.957   19.775  30.378  1.00 36.74 ? 72  ASP H OD1 1 
ATOM   571  O OD2 . ASP A 1 73  ? 1.050   20.472  31.207  1.00 36.81 ? 72  ASP H OD2 1 
ATOM   572  N N   . THR A 1 74  ? 4.122   17.423  28.399  1.00 29.66 ? 73  THR H N   1 
ATOM   573  C CA  . THR A 1 74  ? 5.475   16.971  28.711  1.00 31.60 ? 73  THR H CA  1 
ATOM   574  C C   . THR A 1 74  ? 6.059   17.705  29.916  1.00 34.43 ? 73  THR H C   1 
ATOM   575  O O   . THR A 1 74  ? 6.898   17.145  30.631  1.00 39.14 ? 73  THR H O   1 
ATOM   576  C CB  . THR A 1 74  ? 6.395   17.151  27.512  1.00 29.69 ? 73  THR H CB  1 
ATOM   577  O OG1 . THR A 1 74  ? 6.328   18.509  27.066  1.00 32.48 ? 73  THR H OG1 1 
ATOM   578  C CG2 . THR A 1 74  ? 6.001   16.200  26.382  1.00 30.12 ? 73  THR H CG2 1 
ATOM   579  N N   . SER A 1 75  ? 5.642   18.945  30.160  1.00 29.53 ? 74  SER H N   1 
ATOM   580  C CA  . SER A 1 75  ? 6.257   19.702  31.240  1.00 38.51 ? 74  SER H CA  1 
ATOM   581  C C   . SER A 1 75  ? 6.000   19.060  32.603  1.00 43.92 ? 74  SER H C   1 
ATOM   582  O O   . SER A 1 75  ? 6.790   19.276  33.531  1.00 41.58 ? 74  SER H O   1 
ATOM   583  C CB  . SER A 1 75  ? 5.774   21.161  31.217  1.00 37.65 ? 74  SER H CB  1 
ATOM   584  O OG  . SER A 1 75  ? 4.478   21.329  31.769  1.00 35.90 ? 74  SER H OG  1 
ATOM   585  N N   . ILE A 1 76  ? 4.948   18.246  32.735  1.00 37.29 ? 75  ILE H N   1 
ATOM   586  C CA  . ILE A 1 76  ? 4.677   17.504  33.959  1.00 33.12 ? 75  ILE H CA  1 
ATOM   587  C C   . ILE A 1 76  ? 4.598   15.997  33.709  1.00 37.45 ? 75  ILE H C   1 
ATOM   588  O O   . ILE A 1 76  ? 4.033   15.265  34.522  1.00 34.38 ? 75  ILE H O   1 
ATOM   589  C CB  . ILE A 1 76  ? 3.403   18.015  34.656  1.00 34.30 ? 75  ILE H CB  1 
ATOM   590  C CG1 . ILE A 1 76  ? 2.204   17.923  33.710  1.00 32.68 ? 75  ILE H CG1 1 
ATOM   591  C CG2 . ILE A 1 76  ? 3.616   19.444  35.171  1.00 28.76 ? 75  ILE H CG2 1 
ATOM   592  C CD1 . ILE A 1 76  ? 0.876   18.276  34.360  1.00 27.79 ? 75  ILE H CD1 1 
ATOM   593  N N   . SER A 1 77  ? 5.151   15.529  32.586  1.00 35.82 ? 76  SER H N   1 
ATOM   594  C CA  . SER A 1 77  ? 5.292   14.098  32.297  1.00 33.36 ? 76  SER H CA  1 
ATOM   595  C C   . SER A 1 77  ? 3.989   13.329  32.519  1.00 32.95 ? 76  SER H C   1 
ATOM   596  O O   . SER A 1 77  ? 3.982   12.235  33.097  1.00 32.54 ? 76  SER H O   1 
ATOM   597  C CB  . SER A 1 77  ? 6.425   13.491  33.127  1.00 37.23 ? 76  SER H CB  1 
ATOM   598  O OG  . SER A 1 77  ? 7.687   13.882  32.620  1.00 38.26 ? 76  SER H OG  1 
ATOM   599  N N   . THR A 1 78  ? 2.878   13.911  32.053  1.00 30.84 ? 77  THR H N   1 
ATOM   600  C CA  . THR A 1 78  ? 1.536   13.388  32.282  1.00 31.77 ? 77  THR H CA  1 
ATOM   601  C C   . THR A 1 78  ? 0.814   13.159  30.957  1.00 35.84 ? 77  THR H C   1 
ATOM   602  O O   . THR A 1 78  ? 0.807   14.039  30.082  1.00 30.94 ? 77  THR H O   1 
ATOM   603  C CB  . THR A 1 78  ? 0.726   14.345  33.171  1.00 32.07 ? 77  THR H CB  1 
ATOM   604  O OG1 . THR A 1 78  ? 1.333   14.400  34.468  1.00 32.23 ? 77  THR H OG1 1 
ATOM   605  C CG2 . THR A 1 78  ? -0.712  13.871  33.330  1.00 27.12 ? 77  THR H CG2 1 
ATOM   606  N N   . ALA A 1 79  ? 0.208   11.978  30.812  1.00 28.71 ? 78  ALA H N   1 
ATOM   607  C CA  . ALA A 1 79  ? -0.648  11.679  29.678  1.00 24.65 ? 78  ALA H CA  1 
ATOM   608  C C   . ALA A 1 79  ? -2.111  11.796  30.096  1.00 29.31 ? 78  ALA H C   1 
ATOM   609  O O   . ALA A 1 79  ? -2.450  11.710  31.278  1.00 24.62 ? 78  ALA H O   1 
ATOM   610  C CB  . ALA A 1 79  ? -0.354  10.283  29.130  1.00 23.97 ? 78  ALA H CB  1 
ATOM   611  N N   . TYR A 1 80  ? -2.977  12.027  29.111  1.00 26.53 ? 79  TYR H N   1 
ATOM   612  C CA  . TYR A 1 80  ? -4.409  12.155  29.350  1.00 25.03 ? 79  TYR H CA  1 
ATOM   613  C C   . TYR A 1 80  ? -5.171  11.404  28.278  1.00 23.93 ? 79  TYR H C   1 
ATOM   614  O O   . TYR A 1 80  ? -4.798  11.444  27.104  1.00 24.66 ? 79  TYR H O   1 
ATOM   615  C CB  . TYR A 1 80  ? -4.881  13.618  29.330  1.00 26.67 ? 79  TYR H CB  1 
ATOM   616  C CG  . TYR A 1 80  ? -4.128  14.521  30.260  1.00 30.07 ? 79  TYR H CG  1 
ATOM   617  C CD1 . TYR A 1 80  ? -4.543  14.690  31.564  1.00 25.47 ? 79  TYR H CD1 1 
ATOM   618  C CD2 . TYR A 1 80  ? -2.991  15.215  29.830  1.00 29.71 ? 79  TYR H CD2 1 
ATOM   619  C CE1 . TYR A 1 80  ? -3.850  15.521  32.433  1.00 30.26 ? 79  TYR H CE1 1 
ATOM   620  C CE2 . TYR A 1 80  ? -2.293  16.046  30.685  1.00 30.83 ? 79  TYR H CE2 1 
ATOM   621  C CZ  . TYR A 1 80  ? -2.731  16.203  31.991  1.00 33.77 ? 79  TYR H CZ  1 
ATOM   622  O OH  . TYR A 1 80  ? -2.046  17.025  32.867  1.00 30.80 ? 79  TYR H OH  1 
ATOM   623  N N   . MET A 1 81  ? -6.260  10.754  28.681  1.00 25.94 ? 80  MET H N   1 
ATOM   624  C CA  . MET A 1 81  ? -7.204  10.131  27.759  1.00 24.31 ? 80  MET H CA  1 
ATOM   625  C C   . MET A 1 81  ? -8.586  10.701  28.072  1.00 24.98 ? 80  MET H C   1 
ATOM   626  O O   . MET A 1 81  ? -9.027  10.650  29.225  1.00 23.86 ? 80  MET H O   1 
ATOM   627  C CB  . MET A 1 81  ? -7.189  8.593   27.910  1.00 24.94 ? 80  MET H CB  1 
ATOM   628  C CG  . MET A 1 81  ? -8.031  7.774   26.907  1.00 21.62 ? 80  MET H CG  1 
ATOM   629  S SD  . MET A 1 81  ? -9.817  7.772   27.232  1.00 25.02 ? 80  MET H SD  1 
ATOM   630  C CE  . MET A 1 81  ? -9.817  7.047   28.878  1.00 23.41 ? 80  MET H CE  1 
ATOM   631  N N   . GLU A 1 82  ? -9.268  11.237  27.054  1.00 23.49 ? 81  GLU H N   1 
ATOM   632  C CA  . GLU A 1 82  ? -10.633 11.729  27.195  1.00 25.01 ? 81  GLU H CA  1 
ATOM   633  C C   . GLU A 1 82  ? -11.527 10.917  26.278  1.00 24.93 ? 81  GLU H C   1 
ATOM   634  O O   . GLU A 1 82  ? -11.265 10.824  25.074  1.00 24.30 ? 81  GLU H O   1 
ATOM   635  C CB  . GLU A 1 82  ? -10.749 13.220  26.868  1.00 25.68 ? 81  GLU H CB  1 
ATOM   636  C CG  . GLU A 1 82  ? -12.181 13.724  27.022  1.00 29.68 ? 81  GLU H CG  1 
ATOM   637  C CD  . GLU A 1 82  ? -12.299 15.222  26.832  1.00 35.30 ? 81  GLU H CD  1 
ATOM   638  O OE1 . GLU A 1 82  ? -11.591 15.754  25.965  1.00 44.12 ? 81  GLU H OE1 1 
ATOM   639  O OE2 . GLU A 1 82  ? -13.084 15.867  27.562  1.00 43.77 ? 81  GLU H OE2 1 
ATOM   640  N N   . LEU A 1 83  ? -12.566 10.316  26.846  1.00 22.57 ? 82  LEU H N   1 
ATOM   641  C CA  . LEU A 1 83  ? -13.530 9.535   26.084  1.00 20.99 ? 82  LEU H CA  1 
ATOM   642  C C   . LEU A 1 83  ? -14.895 10.227  26.147  1.00 26.98 ? 82  LEU H C   1 
ATOM   643  O O   . LEU A 1 83  ? -15.367 10.585  27.234  1.00 23.21 ? 82  LEU H O   1 
ATOM   644  C CB  . LEU A 1 83  ? -13.587 8.102   26.628  1.00 19.60 ? 82  LEU H CB  1 
ATOM   645  C CG  . LEU A 1 83  ? -14.426 7.091   25.825  1.00 24.74 ? 82  LEU H CG  1 
ATOM   646  C CD1 . LEU A 1 83  ? -13.874 6.900   24.380  1.00 23.52 ? 82  LEU H CD1 1 
ATOM   647  C CD2 . LEU A 1 83  ? -14.521 5.734   26.544  1.00 20.05 ? 82  LEU H CD2 1 
ATOM   648  N N   . SER A 1 84  A -15.524 10.425  24.990  1.00 24.08 ? 82  SER H N   1 
ATOM   649  C CA  . SER A 1 84  A -16.753 11.210  24.884  1.00 25.10 ? 82  SER H CA  1 
ATOM   650  C C   . SER A 1 84  A -17.950 10.326  24.553  1.00 24.07 ? 82  SER H C   1 
ATOM   651  O O   . SER A 1 84  A -17.803 9.147   24.230  1.00 22.70 ? 82  SER H O   1 
ATOM   652  C CB  . SER A 1 84  A -16.608 12.302  23.816  1.00 24.76 ? 82  SER H CB  1 
ATOM   653  O OG  . SER A 1 84  A -15.707 13.279  24.295  1.00 32.10 ? 82  SER H OG  1 
ATOM   654  N N   . ARG A 1 85  B -19.146 10.930  24.619  1.00 24.91 ? 82  ARG H N   1 
ATOM   655  C CA  . ARG A 1 85  B -20.401 10.241  24.310  1.00 21.57 ? 82  ARG H CA  1 
ATOM   656  C C   . ARG A 1 85  B -20.512 8.910   25.046  1.00 22.74 ? 82  ARG H C   1 
ATOM   657  O O   . ARG A 1 85  B -20.824 7.873   24.459  1.00 25.55 ? 82  ARG H O   1 
ATOM   658  C CB  . ARG A 1 85  B -20.558 10.032  22.813  1.00 25.77 ? 82  ARG H CB  1 
ATOM   659  C CG  . ARG A 1 85  B -20.950 11.289  22.118  1.00 29.85 ? 82  ARG H CG  1 
ATOM   660  C CD  . ARG A 1 85  B -20.992 11.092  20.649  1.00 40.59 ? 82  ARG H CD  1 
ATOM   661  N NE  . ARG A 1 85  B -19.831 11.736  20.074  1.00 41.61 ? 82  ARG H NE  1 
ATOM   662  C CZ  . ARG A 1 85  B -18.834 11.099  19.485  1.00 44.58 ? 82  ARG H CZ  1 
ATOM   663  N NH1 . ARG A 1 85  B -18.856 9.784   19.314  1.00 47.86 ? 82  ARG H NH1 1 
ATOM   664  N NH2 . ARG A 1 85  B -17.803 11.802  19.032  1.00 40.25 ? 82  ARG H NH2 1 
ATOM   665  N N   . LEU A 1 86  C -20.237 8.950   26.347  1.00 22.01 ? 82  LEU H N   1 
ATOM   666  C CA  . LEU A 1 86  C -20.178 7.727   27.138  1.00 24.44 ? 82  LEU H CA  1 
ATOM   667  C C   . LEU A 1 86  C -21.531 7.025   27.187  1.00 28.26 ? 82  LEU H C   1 
ATOM   668  O O   . LEU A 1 86  C -22.586 7.669   27.236  1.00 25.11 ? 82  LEU H O   1 
ATOM   669  C CB  . LEU A 1 86  C -19.715 8.053   28.547  1.00 22.47 ? 82  LEU H CB  1 
ATOM   670  C CG  . LEU A 1 86  C -18.286 8.577   28.638  1.00 21.51 ? 82  LEU H CG  1 
ATOM   671  C CD1 . LEU A 1 86  C -18.041 9.141   30.001  1.00 24.79 ? 82  LEU H CD1 1 
ATOM   672  C CD2 . LEU A 1 86  C -17.318 7.454   28.332  1.00 21.71 ? 82  LEU H CD2 1 
ATOM   673  N N   . THR A 1 87  ? -21.492 5.691   27.149  1.00 27.32 ? 83  THR H N   1 
ATOM   674  C CA  . THR A 1 87  ? -22.635 4.832   27.438  1.00 25.31 ? 83  THR H CA  1 
ATOM   675  C C   . THR A 1 87  ? -22.215 3.782   28.462  1.00 28.01 ? 83  THR H C   1 
ATOM   676  O O   . THR A 1 87  ? -21.028 3.622   28.771  1.00 23.84 ? 83  THR H O   1 
ATOM   677  C CB  . THR A 1 87  ? -23.156 4.102   26.194  1.00 25.94 ? 83  THR H CB  1 
ATOM   678  O OG1 . THR A 1 87  ? -22.334 2.956   25.957  1.00 24.26 ? 83  THR H OG1 1 
ATOM   679  C CG2 . THR A 1 87  ? -23.175 5.011   24.947  1.00 25.20 ? 83  THR H CG2 1 
ATOM   680  N N   . SER A 1 88  ? -23.195 3.014   28.959  1.00 27.51 ? 84  SER H N   1 
ATOM   681  C CA  . SER A 1 88  ? -22.868 2.012   29.968  1.00 29.08 ? 84  SER H CA  1 
ATOM   682  C C   . SER A 1 88  ? -21.869 0.985   29.452  1.00 23.30 ? 84  SER H C   1 
ATOM   683  O O   . SER A 1 88  ? -21.155 0.392   30.254  1.00 25.80 ? 84  SER H O   1 
ATOM   684  C CB  . SER A 1 88  ? -24.134 1.322   30.470  1.00 22.37 ? 84  SER H CB  1 
ATOM   685  O OG  . SER A 1 88  ? -24.820 0.734   29.393  1.00 27.74 ? 84  SER H OG  1 
ATOM   686  N N   . ASP A 1 89  ? -21.770 0.801   28.130  1.00 25.62 ? 85  ASP H N   1 
ATOM   687  C CA  . ASP A 1 89  ? -20.729 -0.037  27.532  1.00 24.23 ? 85  ASP H CA  1 
ATOM   688  C C   . ASP A 1 89  ? -19.306 0.425   27.864  1.00 26.21 ? 85  ASP H C   1 
ATOM   689  O O   . ASP A 1 89  ? -18.360 -0.361  27.734  1.00 30.07 ? 85  ASP H O   1 
ATOM   690  C CB  . ASP A 1 89  ? -20.884 -0.049  26.006  1.00 28.81 ? 85  ASP H CB  1 
ATOM   691  C CG  . ASP A 1 89  ? -22.016 -0.930  25.530  1.00 33.51 ? 85  ASP H CG  1 
ATOM   692  O OD1 . ASP A 1 89  ? -22.573 -1.696  26.331  1.00 30.62 ? 85  ASP H OD1 1 
ATOM   693  O OD2 . ASP A 1 89  ? -22.347 -0.858  24.328  1.00 47.91 ? 85  ASP H OD2 1 
ATOM   694  N N   . ASP A 1 90  ? -19.117 1.682   28.236  1.00 23.23 ? 86  ASP H N   1 
ATOM   695  C CA  . ASP A 1 90  ? -17.810 2.208   28.591  1.00 20.16 ? 86  ASP H CA  1 
ATOM   696  C C   . ASP A 1 90  ? -17.475 2.016   30.062  1.00 21.87 ? 86  ASP H C   1 
ATOM   697  O O   . ASP A 1 90  ? -16.369 2.376   30.478  1.00 21.91 ? 86  ASP H O   1 
ATOM   698  C CB  . ASP A 1 90  ? -17.727 3.692   28.232  1.00 20.08 ? 86  ASP H CB  1 
ATOM   699  C CG  . ASP A 1 90  ? -17.996 3.927   26.766  1.00 24.67 ? 86  ASP H CG  1 
ATOM   700  O OD1 . ASP A 1 90  ? -17.413 3.192   25.943  1.00 23.45 ? 86  ASP H OD1 1 
ATOM   701  O OD2 . ASP A 1 90  ? -18.817 4.798   26.433  1.00 24.30 ? 86  ASP H OD2 1 
ATOM   702  N N   . THR A 1 91  ? -18.397 1.471   30.864  1.00 20.29 ? 87  THR H N   1 
ATOM   703  C CA  . THR A 1 91  ? -18.047 1.156   32.244  1.00 19.08 ? 87  THR H CA  1 
ATOM   704  C C   . THR A 1 91  ? -16.910 0.151   32.249  1.00 23.58 ? 87  THR H C   1 
ATOM   705  O O   . THR A 1 91  ? -16.947 -0.854  31.532  1.00 21.16 ? 87  THR H O   1 
ATOM   706  C CB  . THR A 1 91  ? -19.258 0.613   33.007  1.00 24.26 ? 87  THR H CB  1 
ATOM   707  O OG1 . THR A 1 91  ? -20.238 1.646   33.096  1.00 24.58 ? 87  THR H OG1 1 
ATOM   708  C CG2 . THR A 1 91  ? -18.870 0.231   34.433  1.00 20.51 ? 87  THR H CG2 1 
ATOM   709  N N   . GLY A 1 92  ? -15.870 0.451   33.014  1.00 22.16 ? 88  GLY H N   1 
ATOM   710  C CA  . GLY A 1 92  ? -14.759 -0.462  33.138  1.00 22.71 ? 88  GLY H CA  1 
ATOM   711  C C   . GLY A 1 92  ? -13.555 0.253   33.724  1.00 24.39 ? 88  GLY H C   1 
ATOM   712  O O   . GLY A 1 92  ? -13.627 1.420   34.100  1.00 23.66 ? 88  GLY H O   1 
ATOM   713  N N   . VAL A 1 93  ? -12.449 -0.482  33.790  1.00 21.62 ? 89  VAL H N   1 
ATOM   714  C CA  . VAL A 1 93  ? -11.200 0.048   34.333  1.00 24.19 ? 89  VAL H CA  1 
ATOM   715  C C   . VAL A 1 93  ? -10.304 0.436   33.164  1.00 24.38 ? 89  VAL H C   1 
ATOM   716  O O   . VAL A 1 93  ? -10.140 -0.341  32.216  1.00 23.47 ? 89  VAL H O   1 
ATOM   717  C CB  . VAL A 1 93  ? -10.501 -0.974  35.250  1.00 25.64 ? 89  VAL H CB  1 
ATOM   718  C CG1 . VAL A 1 93  ? -9.163  -0.421  35.719  1.00 20.93 ? 89  VAL H CG1 1 
ATOM   719  C CG2 . VAL A 1 93  ? -11.383 -1.293  36.462  1.00 22.18 ? 89  VAL H CG2 1 
ATOM   720  N N   . TYR A 1 94  ? -9.737  1.637   33.229  1.00 22.42 ? 90  TYR H N   1 
ATOM   721  C CA  . TYR A 1 94  ? -8.911  2.207   32.171  1.00 22.63 ? 90  TYR H CA  1 
ATOM   722  C C   . TYR A 1 94  ? -7.464  2.272   32.659  1.00 21.64 ? 90  TYR H C   1 
ATOM   723  O O   . TYR A 1 94  ? -7.210  2.669   33.799  1.00 24.03 ? 90  TYR H O   1 
ATOM   724  C CB  . TYR A 1 94  ? -9.449  3.595   31.783  1.00 23.05 ? 90  TYR H CB  1 
ATOM   725  C CG  . TYR A 1 94  ? -10.780 3.522   31.054  1.00 20.38 ? 90  TYR H CG  1 
ATOM   726  C CD1 . TYR A 1 94  ? -11.959 3.292   31.735  1.00 19.75 ? 90  TYR H CD1 1 
ATOM   727  C CD2 . TYR A 1 94  ? -10.840 3.620   29.661  1.00 24.73 ? 90  TYR H CD2 1 
ATOM   728  C CE1 . TYR A 1 94  ? -13.175 3.178   31.050  1.00 21.21 ? 90  TYR H CE1 1 
ATOM   729  C CE2 . TYR A 1 94  ? -12.034 3.528   28.973  1.00 18.97 ? 90  TYR H CE2 1 
ATOM   730  C CZ  . TYR A 1 94  ? -13.197 3.303   29.667  1.00 22.71 ? 90  TYR H CZ  1 
ATOM   731  O OH  . TYR A 1 94  ? -14.385 3.202   28.964  1.00 22.41 ? 90  TYR H OH  1 
ATOM   732  N N   . TYR A 1 95  ? -6.529  1.826   31.830  1.00 23.82 ? 91  TYR H N   1 
ATOM   733  C CA  . TYR A 1 95  ? -5.124  1.756   32.203  1.00 22.11 ? 91  TYR H CA  1 
ATOM   734  C C   . TYR A 1 95  ? -4.284  2.543   31.212  1.00 24.91 ? 91  TYR H C   1 
ATOM   735  O O   . TYR A 1 95  ? -4.475  2.417   30.002  1.00 22.33 ? 91  TYR H O   1 
ATOM   736  C CB  . TYR A 1 95  ? -4.585  0.314   32.206  1.00 22.81 ? 91  TYR H CB  1 
ATOM   737  C CG  . TYR A 1 95  ? -5.236  -0.669  33.169  1.00 22.22 ? 91  TYR H CG  1 
ATOM   738  C CD1 . TYR A 1 95  ? -4.865  -0.703  34.507  1.00 25.69 ? 91  TYR H CD1 1 
ATOM   739  C CD2 . TYR A 1 95  ? -6.164  -1.596  32.723  1.00 25.72 ? 91  TYR H CD2 1 
ATOM   740  C CE1 . TYR A 1 95  ? -5.434  -1.602  35.391  1.00 29.26 ? 91  TYR H CE1 1 
ATOM   741  C CE2 . TYR A 1 95  ? -6.739  -2.515  33.597  1.00 30.42 ? 91  TYR H CE2 1 
ATOM   742  C CZ  . TYR A 1 95  ? -6.363  -2.512  34.931  1.00 30.69 ? 91  TYR H CZ  1 
ATOM   743  O OH  . TYR A 1 95  ? -6.926  -3.401  35.813  1.00 36.52 ? 91  TYR H OH  1 
ATOM   744  N N   . CYS A 1 96  ? -3.323  3.306   31.720  1.00 21.36 ? 92  CYS H N   1 
ATOM   745  C CA  . CYS A 1 96  ? -2.201  3.712   30.884  1.00 25.59 ? 92  CYS H CA  1 
ATOM   746  C C   . CYS A 1 96  ? -1.045  2.748   31.071  1.00 24.97 ? 92  CYS H C   1 
ATOM   747  O O   . CYS A 1 96  ? -0.853  2.173   32.153  1.00 23.99 ? 92  CYS H O   1 
ATOM   748  C CB  . CYS A 1 96  ? -1.736  5.126   31.211  1.00 24.63 ? 92  CYS H CB  1 
ATOM   749  S SG  . CYS A 1 96  ? -1.216  5.323   32.938  1.00 29.88 ? 92  CYS H SG  1 
ATOM   750  N N   . ALA A 1 97  ? -0.279  2.561   30.001  1.00 20.47 ? 93  ALA H N   1 
ATOM   751  C CA  . ALA A 1 97  ? 0.895   1.706   30.051  1.00 22.95 ? 93  ALA H CA  1 
ATOM   752  C C   . ALA A 1 97  ? 1.932   2.203   29.057  1.00 28.24 ? 93  ALA H C   1 
ATOM   753  O O   . ALA A 1 97  ? 1.602   2.673   27.964  1.00 24.60 ? 93  ALA H O   1 
ATOM   754  C CB  . ALA A 1 97  ? 0.582   0.238   29.753  1.00 24.33 ? 93  ALA H CB  1 
ATOM   755  N N   . ARG A 1 98  ? 3.192   2.026   29.442  1.00 26.28 ? 94  ARG H N   1 
ATOM   756  C CA  . ARG A 1 98  ? 4.348   2.465   28.688  1.00 24.70 ? 94  ARG H CA  1 
ATOM   757  C C   . ARG A 1 98  ? 4.863   1.338   27.803  1.00 27.48 ? 94  ARG H C   1 
ATOM   758  O O   . ARG A 1 98  ? 4.904   0.179   28.222  1.00 25.61 ? 94  ARG H O   1 
ATOM   759  C CB  . ARG A 1 98  ? 5.411   2.902   29.690  1.00 30.80 ? 94  ARG H CB  1 
ATOM   760  C CG  . ARG A 1 98  ? 6.687   3.369   29.134  1.00 31.98 ? 94  ARG H CG  1 
ATOM   761  C CD  . ARG A 1 98  ? 7.696   3.542   30.267  1.00 32.88 ? 94  ARG H CD  1 
ATOM   762  N NE  . ARG A 1 98  ? 8.529   2.361   30.461  1.00 31.08 ? 94  ARG H NE  1 
ATOM   763  C CZ  . ARG A 1 98  ? 9.777   2.413   30.916  1.00 36.61 ? 94  ARG H CZ  1 
ATOM   764  N NH1 . ARG A 1 98  ? 10.331  3.565   31.269  1.00 32.76 ? 94  ARG H NH1 1 
ATOM   765  N NH2 . ARG A 1 98  ? 10.488  1.287   31.008  1.00 27.39 ? 94  ARG H NH2 1 
ATOM   766  N N   . SER A 1 99  ? 5.259   1.676   26.579  1.00 25.32 ? 95  SER H N   1 
ATOM   767  C CA  . SER A 1 99  ? 5.987   0.789   25.691  1.00 24.69 ? 95  SER H CA  1 
ATOM   768  C C   . SER A 1 99  ? 7.230   1.490   25.185  1.00 25.78 ? 95  SER H C   1 
ATOM   769  O O   . SER A 1 99  ? 7.348   2.723   25.293  1.00 25.39 ? 95  SER H O   1 
ATOM   770  C CB  . SER A 1 99  ? 5.096   0.357   24.507  1.00 30.40 ? 95  SER H CB  1 
ATOM   771  O OG  . SER A 1 99  ? 4.904   1.410   23.575  1.00 23.79 ? 95  SER H OG  1 
ATOM   772  N N   . PRO A 1 100 ? 8.183   0.769   24.601  1.00 23.66 ? 96  PRO H N   1 
ATOM   773  C CA  . PRO A 1 100 ? 9.236   1.454   23.844  1.00 26.79 ? 96  PRO H CA  1 
ATOM   774  C C   . PRO A 1 100 ? 8.621   2.283   22.719  1.00 28.28 ? 96  PRO H C   1 
ATOM   775  O O   . PRO A 1 100 ? 7.560   1.947   22.177  1.00 27.26 ? 96  PRO H O   1 
ATOM   776  C CB  . PRO A 1 100 ? 10.103  0.313   23.292  1.00 26.07 ? 96  PRO H CB  1 
ATOM   777  C CG  . PRO A 1 100 ? 9.793   -0.884  24.164  1.00 31.39 ? 96  PRO H CG  1 
ATOM   778  C CD  . PRO A 1 100 ? 8.326   -0.701  24.523  1.00 29.18 ? 96  PRO H CD  1 
ATOM   779  N N   . ALA A 1 101 ? 9.290   3.394   22.389  1.00 26.89 ? 97  ALA H N   1 
ATOM   780  C CA  . ALA A 1 101 ? 8.834   4.260   21.307  1.00 27.01 ? 97  ALA H CA  1 
ATOM   781  C C   . ALA A 1 101 ? 8.647   3.462   20.029  1.00 21.33 ? 97  ALA H C   1 
ATOM   782  O O   . ALA A 1 101 ? 9.394   2.521   19.745  1.00 23.43 ? 97  ALA H O   1 
ATOM   783  C CB  . ALA A 1 101 ? 9.831   5.393   21.061  1.00 25.94 ? 97  ALA H CB  1 
ATOM   784  N N   . ARG A 1 102 ? 7.603   3.810   19.280  1.00 26.93 ? 98  ARG H N   1 
ATOM   785  C CA  . ARG A 1 102 ? 7.328   3.192   17.986  1.00 23.25 ? 98  ARG H CA  1 
ATOM   786  C C   . ARG A 1 102 ? 7.138   1.685   18.102  1.00 25.19 ? 98  ARG H C   1 
ATOM   787  O O   . ARG A 1 102 ? 7.417   0.944   17.153  1.00 25.67 ? 98  ARG H O   1 
ATOM   788  C CB  . ARG A 1 102 ? 8.432   3.519   16.969  1.00 25.37 ? 98  ARG H CB  1 
ATOM   789  C CG  . ARG A 1 102 ? 8.155   4.819   16.225  1.00 32.50 ? 98  ARG H CG  1 
ATOM   790  C CD  . ARG A 1 102 ? 9.388   5.374   15.554  1.00 24.68 ? 98  ARG H CD  1 
ATOM   791  N NE  . ARG A 1 102 ? 10.049  6.269   16.490  1.00 37.39 ? 98  ARG H NE  1 
ATOM   792  C CZ  . ARG A 1 102 ? 11.235  6.053   17.042  1.00 34.57 ? 98  ARG H CZ  1 
ATOM   793  N NH1 . ARG A 1 102 ? 11.982  5.014   16.698  1.00 39.69 ? 98  ARG H NH1 1 
ATOM   794  N NH2 . ARG A 1 102 ? 11.683  6.905   17.959  1.00 30.48 ? 98  ARG H NH2 1 
ATOM   795  N N   . GLU A 1 103 ? 6.679   1.214   19.265  1.00 22.19 ? 99  GLU H N   1 
ATOM   796  C CA  . GLU A 1 103 ? 6.355   -0.190  19.465  1.00 23.82 ? 99  GLU H CA  1 
ATOM   797  C C   . GLU A 1 103 ? 4.981   -0.299  20.120  1.00 23.56 ? 99  GLU H C   1 
ATOM   798  O O   . GLU A 1 103 ? 4.463   0.659   20.697  1.00 24.27 ? 99  GLU H O   1 
ATOM   799  C CB  . GLU A 1 103 ? 7.421   -0.910  20.342  1.00 28.32 ? 99  GLU H CB  1 
ATOM   800  C CG  . GLU A 1 103 ? 8.873   -0.853  19.803  1.00 26.28 ? 99  GLU H CG  1 
ATOM   801  C CD  . GLU A 1 103 ? 9.088   -1.730  18.571  1.00 25.42 ? 99  GLU H CD  1 
ATOM   802  O OE1 . GLU A 1 103 ? 8.193   -2.533  18.233  1.00 26.52 ? 99  GLU H OE1 1 
ATOM   803  O OE2 . GLU A 1 103 ? 10.146  -1.608  17.913  1.00 28.76 ? 99  GLU H OE2 1 
ATOM   804  N N   . LEU A 1 104 ? 4.373   -1.470  19.980  1.00 22.84 ? 100 LEU H N   1 
ATOM   805  C CA  . LEU A 1 104 ? 3.038   -1.720  20.589  1.00 29.32 ? 100 LEU H CA  1 
ATOM   806  C C   . LEU A 1 104 ? 3.100   -2.931  21.519  1.00 28.19 ? 100 LEU H C   1 
ATOM   807  O O   . LEU A 1 104 ? 2.131   -3.125  22.277  1.00 26.00 ? 100 LEU H O   1 
ATOM   808  C CB  . LEU A 1 104 ? 2.057   -2.079  19.472  1.00 26.76 ? 100 LEU H CB  1 
ATOM   809  C CG  . LEU A 1 104 ? 1.519   -0.947  18.604  1.00 24.92 ? 100 LEU H CG  1 
ATOM   810  C CD1 . LEU A 1 104 ? 1.143   -1.502  17.243  1.00 25.66 ? 100 LEU H CD1 1 
ATOM   811  C CD2 . LEU A 1 104 ? 0.302   -0.316  19.256  1.00 25.47 ? 100 LEU H CD2 1 
ATOM   812  N N   . LEU A 1 105 A 4.181   -3.714  21.473  1.00 26.61 ? 100 LEU H N   1 
ATOM   813  C CA  . LEU A 1 105 A 4.205   -5.006  22.220  1.00 36.77 ? 100 LEU H CA  1 
ATOM   814  C C   . LEU A 1 105 A 4.586   -4.884  23.701  1.00 40.50 ? 100 LEU H C   1 
ATOM   815  O O   . LEU A 1 105 A 3.688   -5.101  24.536  1.00 49.65 ? 100 LEU H O   1 
ATOM   816  C CB  . LEU A 1 105 A 5.156   -5.961  21.488  1.00 42.61 ? 100 LEU H CB  1 
ATOM   817  C CG  . LEU A 1 105 A 4.950   -7.446  21.755  1.00 38.96 ? 100 LEU H CG  1 
ATOM   818  C CD1 . LEU A 1 105 A 5.916   -7.919  22.827  1.00 36.79 ? 100 LEU H CD1 1 
ATOM   819  C CD2 . LEU A 1 105 A 3.507   -7.724  22.145  1.00 26.44 ? 100 LEU H CD2 1 
ATOM   820  N N   . PRO A 1 106 B 5.841   -4.567  24.095  1.00 41.91 ? 100 PRO H N   1 
ATOM   821  C CA  . PRO A 1 106 B 6.247   -4.637  25.508  1.00 30.21 ? 100 PRO H CA  1 
ATOM   822  C C   . PRO A 1 106 B 5.650   -3.558  26.418  1.00 23.66 ? 100 PRO H C   1 
ATOM   823  O O   . PRO A 1 106 B 6.313   -2.524  26.535  1.00 28.42 ? 100 PRO H O   1 
ATOM   824  C CB  . PRO A 1 106 B 7.776   -4.455  25.472  1.00 32.79 ? 100 PRO H CB  1 
ATOM   825  C CG  . PRO A 1 106 B 8.143   -4.544  24.006  1.00 32.50 ? 100 PRO H CG  1 
ATOM   826  C CD  . PRO A 1 106 B 6.927   -4.013  23.281  1.00 27.19 ? 100 PRO H CD  1 
ATOM   827  N N   . LEU A 1 107 C 4.467   -3.817  27.009  1.00 24.71 ? 100 LEU H N   1 
ATOM   828  C CA  . LEU A 1 107 C 3.909   -2.877  27.985  1.00 23.44 ? 100 LEU H CA  1 
ATOM   829  C C   . LEU A 1 107 C 4.473   -3.245  29.363  1.00 30.54 ? 100 LEU H C   1 
ATOM   830  O O   . LEU A 1 107 C 3.885   -4.032  30.118  1.00 29.43 ? 100 LEU H O   1 
ATOM   831  C CB  . LEU A 1 107 C 2.391   -2.924  27.967  1.00 24.27 ? 100 LEU H CB  1 
ATOM   832  C CG  . LEU A 1 107 C 1.771   -2.564  26.619  1.00 22.57 ? 100 LEU H CG  1 
ATOM   833  C CD1 . LEU A 1 107 C 0.327   -3.067  26.580  1.00 25.49 ? 100 LEU H CD1 1 
ATOM   834  C CD2 . LEU A 1 107 C 1.850   -1.047  26.366  1.00 19.05 ? 100 LEU H CD2 1 
ATOM   835  N N   . ASP A 1 108 ? 5.625   -2.668  29.710  1.00 29.15 ? 101 ASP H N   1 
ATOM   836  C CA  . ASP A 1 108 ? 6.334   -3.177  30.879  1.00 32.51 ? 101 ASP H CA  1 
ATOM   837  C C   . ASP A 1 108 ? 5.855   -2.559  32.188  1.00 28.77 ? 101 ASP H C   1 
ATOM   838  O O   . ASP A 1 108 ? 5.800   -3.268  33.195  1.00 33.26 ? 101 ASP H O   1 
ATOM   839  C CB  . ASP A 1 108 ? 7.859   -3.023  30.704  1.00 33.73 ? 101 ASP H CB  1 
ATOM   840  C CG  . ASP A 1 108 ? 8.310   -1.595  30.406  1.00 34.37 ? 101 ASP H CG  1 
ATOM   841  O OD1 . ASP A 1 108 ? 7.466   -0.676  30.314  1.00 28.98 ? 101 ASP H OD1 1 
ATOM   842  O OD2 . ASP A 1 108 ? 9.544   -1.396  30.275  1.00 35.56 ? 101 ASP H OD2 1 
ATOM   843  N N   . TYR A 1 109 ? 5.434   -1.297  32.196  1.00 25.31 ? 102 TYR H N   1 
ATOM   844  C CA  . TYR A 1 109 ? 4.913   -0.637  33.389  1.00 25.29 ? 102 TYR H CA  1 
ATOM   845  C C   . TYR A 1 109 ? 3.519   -0.084  33.129  1.00 28.57 ? 102 TYR H C   1 
ATOM   846  O O   . TYR A 1 109 ? 3.296   0.611   32.130  1.00 25.94 ? 102 TYR H O   1 
ATOM   847  C CB  . TYR A 1 109 ? 5.823   0.507   33.852  1.00 31.46 ? 102 TYR H CB  1 
ATOM   848  C CG  . TYR A 1 109 ? 7.169   0.046   34.374  1.00 33.52 ? 102 TYR H CG  1 
ATOM   849  C CD1 . TYR A 1 109 ? 7.323   -0.340  35.700  1.00 34.03 ? 102 TYR H CD1 1 
ATOM   850  C CD2 . TYR A 1 109 ? 8.276   -0.015  33.534  1.00 31.73 ? 102 TYR H CD2 1 
ATOM   851  C CE1 . TYR A 1 109 ? 8.547   -0.769  36.181  1.00 35.34 ? 102 TYR H CE1 1 
ATOM   852  C CE2 . TYR A 1 109 ? 9.498   -0.433  34.001  1.00 37.60 ? 102 TYR H CE2 1 
ATOM   853  C CZ  . TYR A 1 109 ? 9.630   -0.806  35.330  1.00 35.49 ? 102 TYR H CZ  1 
ATOM   854  O OH  . TYR A 1 109 ? 10.845  -1.227  35.802  1.00 50.76 ? 102 TYR H OH  1 
ATOM   855  N N   . TRP A 1 110 ? 2.607   -0.336  34.061  1.00 26.43 ? 103 TRP H N   1 
ATOM   856  C CA  . TRP A 1 110 ? 1.217   0.048   33.926  1.00 23.36 ? 103 TRP H CA  1 
ATOM   857  C C   . TRP A 1 110 ? 0.810   1.011   35.032  1.00 27.61 ? 103 TRP H C   1 
ATOM   858  O O   . TRP A 1 110 ? 1.365   0.983   36.131  1.00 29.43 ? 103 TRP H O   1 
ATOM   859  C CB  . TRP A 1 110 ? 0.317   -1.168  33.981  1.00 27.02 ? 103 TRP H CB  1 
ATOM   860  C CG  . TRP A 1 110 ? 0.486   -2.130  32.871  1.00 24.47 ? 103 TRP H CG  1 
ATOM   861  C CD1 . TRP A 1 110 ? 1.629   -2.798  32.512  1.00 25.77 ? 103 TRP H CD1 1 
ATOM   862  C CD2 . TRP A 1 110 ? -0.543  -2.589  31.993  1.00 23.02 ? 103 TRP H CD2 1 
ATOM   863  N NE1 . TRP A 1 110 ? 1.372   -3.619  31.438  1.00 23.48 ? 103 TRP H NE1 1 
ATOM   864  C CE2 . TRP A 1 110 ? 0.040   -3.523  31.117  1.00 18.36 ? 103 TRP H CE2 1 
ATOM   865  C CE3 . TRP A 1 110 ? -1.906  -2.305  31.868  1.00 23.34 ? 103 TRP H CE3 1 
ATOM   866  C CZ2 . TRP A 1 110 ? -0.683  -4.143  30.113  1.00 20.54 ? 103 TRP H CZ2 1 
ATOM   867  C CZ3 . TRP A 1 110 ? -2.621  -2.929  30.874  1.00 19.79 ? 103 TRP H CZ3 1 
ATOM   868  C CH2 . TRP A 1 110 ? -2.016  -3.831  30.012  1.00 21.58 ? 103 TRP H CH2 1 
ATOM   869  N N   . GLY A 1 111 ? -0.182  1.857   34.731  1.00 27.19 ? 104 GLY H N   1 
ATOM   870  C CA  . GLY A 1 111 ? -0.850  2.628   35.761  1.00 24.75 ? 104 GLY H CA  1 
ATOM   871  C C   . GLY A 1 111 ? -1.704  1.720   36.632  1.00 27.23 ? 104 GLY H C   1 
ATOM   872  O O   . GLY A 1 111 ? -1.952  0.561   36.307  1.00 24.91 ? 104 GLY H O   1 
ATOM   873  N N   . GLN A 1 112 ? -2.164  2.244   37.768  1.00 24.19 ? 105 GLN H N   1 
ATOM   874  C CA  . GLN A 1 112 ? -2.903  1.366   38.676  1.00 31.66 ? 105 GLN H CA  1 
ATOM   875  C C   . GLN A 1 112 ? -4.347  1.148   38.244  1.00 28.27 ? 105 GLN H C   1 
ATOM   876  O O   . GLN A 1 112 ? -5.033  0.303   38.834  1.00 29.60 ? 105 GLN H O   1 
ATOM   877  C CB  . GLN A 1 112 ? -2.866  1.901   40.110  1.00 26.52 ? 105 GLN H CB  1 
ATOM   878  C CG  . GLN A 1 112 ? -3.876  2.986   40.423  1.00 25.27 ? 105 GLN H CG  1 
ATOM   879  C CD  . GLN A 1 112 ? -3.416  4.367   39.998  1.00 27.86 ? 105 GLN H CD  1 
ATOM   880  O OE1 . GLN A 1 112 ? -2.451  4.518   39.241  1.00 23.59 ? 105 GLN H OE1 1 
ATOM   881  N NE2 . GLN A 1 112 ? -4.107  5.388   40.493  1.00 26.67 ? 105 GLN H NE2 1 
ATOM   882  N N   . GLY A 1 113 ? -4.809  1.848   37.220  1.00 27.72 ? 106 GLY H N   1 
ATOM   883  C CA  . GLY A 1 113 ? -6.173  1.692   36.767  1.00 21.85 ? 106 GLY H CA  1 
ATOM   884  C C   . GLY A 1 113 ? -7.070  2.787   37.305  1.00 28.21 ? 106 GLY H C   1 
ATOM   885  O O   . GLY A 1 113 ? -6.887  3.289   38.421  1.00 29.61 ? 106 GLY H O   1 
ATOM   886  N N   . THR A 1 114 ? -8.049  3.180   36.491  1.00 24.13 ? 107 THR H N   1 
ATOM   887  C CA  . THR A 1 114 ? -9.068  4.147   36.877  1.00 25.61 ? 107 THR H CA  1 
ATOM   888  C C   . THR A 1 114 ? -10.418 3.545   36.555  1.00 25.56 ? 107 THR H C   1 
ATOM   889  O O   . THR A 1 114 ? -10.689 3.232   35.390  1.00 25.91 ? 107 THR H O   1 
ATOM   890  C CB  . THR A 1 114 ? -8.899  5.475   36.126  1.00 26.80 ? 107 THR H CB  1 
ATOM   891  O OG1 . THR A 1 114 ? -7.635  6.050   36.448  1.00 26.78 ? 107 THR H OG1 1 
ATOM   892  C CG2 . THR A 1 114 ? -9.986  6.459   36.512  1.00 25.89 ? 107 THR H CG2 1 
ATOM   893  N N   . LEU A 1 115 ? -11.264 3.389   37.574  1.00 25.26 ? 108 LEU H N   1 
ATOM   894  C CA  . LEU A 1 115 ? -12.628 2.923   37.358  1.00 22.11 ? 108 LEU H CA  1 
ATOM   895  C C   . LEU A 1 115 ? -13.510 4.045   36.817  1.00 22.29 ? 108 LEU H C   1 
ATOM   896  O O   . LEU A 1 115 ? -13.615 5.113   37.425  1.00 24.07 ? 108 LEU H O   1 
ATOM   897  C CB  . LEU A 1 115 ? -13.233 2.401   38.661  1.00 23.77 ? 108 LEU H CB  1 
ATOM   898  C CG  . LEU A 1 115 ? -14.719 2.083   38.559  1.00 24.15 ? 108 LEU H CG  1 
ATOM   899  C CD1 . LEU A 1 115 ? -14.920 1.009   37.525  1.00 25.53 ? 108 LEU H CD1 1 
ATOM   900  C CD2 . LEU A 1 115 ? -15.273 1.610   39.891  1.00 28.29 ? 108 LEU H CD2 1 
ATOM   901  N N   . VAL A 1 116 ? -14.208 3.770   35.724  1.00 21.62 ? 109 VAL H N   1 
ATOM   902  C CA  . VAL A 1 116 ? -15.183 4.687   35.160  1.00 23.10 ? 109 VAL H CA  1 
ATOM   903  C C   . VAL A 1 116 ? -16.528 3.976   35.104  1.00 22.95 ? 109 VAL H C   1 
ATOM   904  O O   . VAL A 1 116 ? -16.660 2.938   34.444  1.00 23.76 ? 109 VAL H O   1 
ATOM   905  C CB  . VAL A 1 116 ? -14.767 5.170   33.766  1.00 26.76 ? 109 VAL H CB  1 
ATOM   906  C CG1 . VAL A 1 116 ? -15.894 6.032   33.149  1.00 19.61 ? 109 VAL H CG1 1 
ATOM   907  C CG2 . VAL A 1 116 ? -13.432 5.927   33.852  1.00 22.57 ? 109 VAL H CG2 1 
ATOM   908  N N   . THR A 1 117 ? -17.533 4.553   35.753  1.00 23.35 ? 110 THR H N   1 
ATOM   909  C CA  . THR A 1 117 ? -18.877 3.980   35.783  1.00 21.90 ? 110 THR H CA  1 
ATOM   910  C C   . THR A 1 117 ? -19.802 4.911   35.029  1.00 23.10 ? 110 THR H C   1 
ATOM   911  O O   . THR A 1 117 ? -19.912 6.086   35.383  1.00 26.07 ? 110 THR H O   1 
ATOM   912  C CB  . THR A 1 117 ? -19.392 3.798   37.215  1.00 23.57 ? 110 THR H CB  1 
ATOM   913  O OG1 . THR A 1 117 ? -18.440 3.058   37.978  1.00 23.04 ? 110 THR H OG1 1 
ATOM   914  C CG2 . THR A 1 117 ? -20.702 3.033   37.199  1.00 24.61 ? 110 THR H CG2 1 
ATOM   915  N N   . VAL A 1 118 ? -20.476 4.389   34.010  1.00 21.43 ? 111 VAL H N   1 
ATOM   916  C CA  . VAL A 1 118 ? -21.395 5.179   33.205  1.00 23.78 ? 111 VAL H CA  1 
ATOM   917  C C   . VAL A 1 118 ? -22.784 4.599   33.412  1.00 25.74 ? 111 VAL H C   1 
ATOM   918  O O   . VAL A 1 118 ? -23.043 3.441   33.050  1.00 24.17 ? 111 VAL H O   1 
ATOM   919  C CB  . VAL A 1 118 ? -21.011 5.198   31.714  1.00 24.55 ? 111 VAL H CB  1 
ATOM   920  C CG1 . VAL A 1 118 ? -21.928 6.159   30.950  1.00 24.26 ? 111 VAL H CG1 1 
ATOM   921  C CG2 . VAL A 1 118 ? -19.503 5.605   31.539  1.00 23.77 ? 111 VAL H CG2 1 
ATOM   922  N N   . SER A 1 119 ? -23.672 5.411   33.982  1.00 27.27 ? 112 SER H N   1 
ATOM   923  C CA  . SER A 1 119 ? -24.999 4.966   34.380  1.00 27.74 ? 112 SER H CA  1 
ATOM   924  C C   . SER A 1 119 ? -25.914 6.176   34.498  1.00 24.43 ? 112 SER H C   1 
ATOM   925  O O   . SER A 1 119 ? -25.467 7.278   34.837  1.00 26.16 ? 112 SER H O   1 
ATOM   926  C CB  . SER A 1 119 ? -24.956 4.214   35.716  1.00 25.96 ? 112 SER H CB  1 
ATOM   927  O OG  . SER A 1 119 ? -26.266 3.834   36.112  1.00 27.72 ? 112 SER H OG  1 
ATOM   928  N N   . SER A 1 120 ? -27.202 5.952   34.245  1.00 26.04 ? 113 SER H N   1 
ATOM   929  C CA  . SER A 1 120 ? -28.199 6.969   34.584  1.00 29.19 ? 113 SER H CA  1 
ATOM   930  C C   . SER A 1 120 ? -28.436 7.087   36.090  1.00 32.17 ? 113 SER H C   1 
ATOM   931  O O   . SER A 1 120 ? -29.041 8.076   36.529  1.00 31.01 ? 113 SER H O   1 
ATOM   932  C CB  . SER A 1 120 ? -29.516 6.675   33.874  1.00 27.76 ? 113 SER H CB  1 
ATOM   933  O OG  . SER A 1 120 ? -30.025 5.409   34.263  1.00 39.69 ? 113 SER H OG  1 
ATOM   934  N N   . ALA A 1 121 ? -27.965 6.126   36.887  1.00 27.79 ? 114 ALA H N   1 
ATOM   935  C CA  . ALA A 1 121 ? -28.060 6.218   38.338  1.00 25.60 ? 114 ALA H CA  1 
ATOM   936  C C   . ALA A 1 121 ? -27.180 7.348   38.848  1.00 25.29 ? 114 ALA H C   1 
ATOM   937  O O   . ALA A 1 121 ? -26.265 7.808   38.155  1.00 24.39 ? 114 ALA H O   1 
ATOM   938  C CB  . ALA A 1 121 ? -27.618 4.904   38.993  1.00 25.58 ? 114 ALA H CB  1 
ATOM   939  N N   . SER A 1 122 ? -27.443 7.769   40.092  1.00 22.60 ? 115 SER H N   1 
ATOM   940  C CA  . SER A 1 122 ? -26.654 8.777   40.795  1.00 25.88 ? 115 SER H CA  1 
ATOM   941  C C   . SER A 1 122 ? -26.099 8.216   42.104  1.00 24.60 ? 115 SER H C   1 
ATOM   942  O O   . SER A 1 122 ? -26.619 7.242   42.646  1.00 24.33 ? 115 SER H O   1 
ATOM   943  C CB  . SER A 1 122 ? -27.498 10.036  41.090  1.00 28.53 ? 115 SER H CB  1 
ATOM   944  O OG  . SER A 1 122 ? -27.844 10.728  39.903  1.00 29.27 ? 115 SER H OG  1 
ATOM   945  N N   . THR A 1 123 ? -25.043 8.864   42.619  1.00 26.34 ? 116 THR H N   1 
ATOM   946  C CA  . THR A 1 123 ? -24.352 8.431   43.836  1.00 24.36 ? 116 THR H CA  1 
ATOM   947  C C   . THR A 1 123 ? -25.321 8.140   44.985  1.00 26.62 ? 116 THR H C   1 
ATOM   948  O O   . THR A 1 123 ? -26.171 8.970   45.322  1.00 24.91 ? 116 THR H O   1 
ATOM   949  C CB  . THR A 1 123 ? -23.360 9.521   44.269  1.00 28.28 ? 116 THR H CB  1 
ATOM   950  O OG1 . THR A 1 123 ? -22.280 9.593   43.334  1.00 32.14 ? 116 THR H OG1 1 
ATOM   951  C CG2 . THR A 1 123 ? -22.795 9.239   45.664  1.00 25.40 ? 116 THR H CG2 1 
ATOM   952  N N   . LYS A 1 124 ? -25.167 6.969   45.617  1.00 20.58 ? 117 LYS H N   1 
ATOM   953  C CA  . LYS A 1 124 ? -26.097 6.545   46.665  1.00 23.20 ? 117 LYS H CA  1 
ATOM   954  C C   . LYS A 1 124 ? -25.374 5.664   47.672  1.00 23.72 ? 117 LYS H C   1 
ATOM   955  O O   . LYS A 1 124 ? -24.786 4.648   47.294  1.00 26.82 ? 117 LYS H O   1 
ATOM   956  C CB  . LYS A 1 124 ? -27.299 5.801   46.061  1.00 23.02 ? 117 LYS H CB  1 
ATOM   957  C CG  . LYS A 1 124 ? -28.348 5.390   47.080  1.00 23.55 ? 117 LYS H CG  1 
ATOM   958  C CD  . LYS A 1 124 ? -29.643 4.990   46.398  1.00 25.90 ? 117 LYS H CD  1 
ATOM   959  C CE  . LYS A 1 124 ? -30.572 4.270   47.373  1.00 33.63 ? 117 LYS H CE  1 
ATOM   960  N NZ  . LYS A 1 124 ? -30.795 5.057   48.609  1.00 30.18 ? 117 LYS H NZ  1 
ATOM   961  N N   . GLY A 1 125 ? -25.400 6.064   48.944  1.00 23.65 ? 118 GLY H N   1 
ATOM   962  C CA  . GLY A 1 125 ? -24.828 5.276   50.013  1.00 23.68 ? 118 GLY H CA  1 
ATOM   963  C C   . GLY A 1 125 ? -25.639 4.017   50.289  1.00 24.34 ? 118 GLY H C   1 
ATOM   964  O O   . GLY A 1 125 ? -26.849 3.971   50.049  1.00 29.60 ? 118 GLY H O   1 
ATOM   965  N N   . PRO A 1 126 ? -24.990 2.977   50.812  1.00 21.99 ? 119 PRO H N   1 
ATOM   966  C CA  . PRO A 1 126 ? -25.684 1.703   51.017  1.00 24.72 ? 119 PRO H CA  1 
ATOM   967  C C   . PRO A 1 126 ? -26.619 1.733   52.208  1.00 22.85 ? 119 PRO H C   1 
ATOM   968  O O   . PRO A 1 126 ? -26.386 2.420   53.201  1.00 25.97 ? 119 PRO H O   1 
ATOM   969  C CB  . PRO A 1 126 ? -24.542 0.719   51.266  1.00 24.52 ? 119 PRO H CB  1 
ATOM   970  C CG  . PRO A 1 126 ? -23.515 1.554   51.968  1.00 27.49 ? 119 PRO H CG  1 
ATOM   971  C CD  . PRO A 1 126 ? -23.596 2.925   51.291  1.00 22.84 ? 119 PRO H CD  1 
ATOM   972  N N   . SER A 1 127 ? -27.666 0.932   52.110  1.00 26.39 ? 120 SER H N   1 
ATOM   973  C CA  . SER A 1 127 ? -28.442 0.523   53.269  1.00 25.71 ? 120 SER H CA  1 
ATOM   974  C C   . SER A 1 127 ? -27.897 -0.824  53.731  1.00 29.00 ? 120 SER H C   1 
ATOM   975  O O   . SER A 1 127 ? -27.876 -1.788  52.954  1.00 27.93 ? 120 SER H O   1 
ATOM   976  C CB  . SER A 1 127 ? -29.921 0.397   52.914  1.00 24.18 ? 120 SER H CB  1 
ATOM   977  O OG  . SER A 1 127 ? -30.443 1.593   52.385  1.00 37.56 ? 120 SER H OG  1 
ATOM   978  N N   . VAL A 1 128 ? -27.474 -0.908  54.986  1.00 25.17 ? 121 VAL H N   1 
ATOM   979  C CA  . VAL A 1 128 ? -26.816 -2.104  55.497  1.00 25.04 ? 121 VAL H CA  1 
ATOM   980  C C   . VAL A 1 128 ? -27.790 -2.789  56.441  1.00 26.59 ? 121 VAL H C   1 
ATOM   981  O O   . VAL A 1 128 ? -28.160 -2.230  57.478  1.00 24.97 ? 121 VAL H O   1 
ATOM   982  C CB  . VAL A 1 128 ? -25.484 -1.770  56.187  1.00 23.67 ? 121 VAL H CB  1 
ATOM   983  C CG1 . VAL A 1 128 ? -24.835 -3.015  56.743  1.00 29.44 ? 121 VAL H CG1 1 
ATOM   984  C CG2 . VAL A 1 128 ? -24.518 -1.099  55.196  1.00 24.60 ? 121 VAL H CG2 1 
ATOM   985  N N   . PHE A 1 129 ? -28.187 -4.008  56.092  1.00 23.80 ? 122 PHE H N   1 
ATOM   986  C CA  . PHE A 1 129 ? -29.094 -4.812  56.873  1.00 23.62 ? 122 PHE H CA  1 
ATOM   987  C C   . PHE A 1 129 ? -28.381 -6.031  57.463  1.00 24.97 ? 122 PHE H C   1 
ATOM   988  O O   . PHE A 1 129 ? -27.481 -6.591  56.823  1.00 25.26 ? 122 PHE H O   1 
ATOM   989  C CB  . PHE A 1 129 ? -30.252 -5.255  55.987  1.00 19.53 ? 122 PHE H CB  1 
ATOM   990  C CG  . PHE A 1 129 ? -30.964 -4.103  55.320  1.00 27.58 ? 122 PHE H CG  1 
ATOM   991  C CD1 . PHE A 1 129 ? -31.695 -3.194  56.075  1.00 32.66 ? 122 PHE H CD1 1 
ATOM   992  C CD2 . PHE A 1 129 ? -30.910 -3.928  53.953  1.00 23.76 ? 122 PHE H CD2 1 
ATOM   993  C CE1 . PHE A 1 129 ? -32.369 -2.136  55.470  1.00 27.68 ? 122 PHE H CE1 1 
ATOM   994  C CE2 . PHE A 1 129 ? -31.587 -2.888  53.337  1.00 31.67 ? 122 PHE H CE2 1 
ATOM   995  C CZ  . PHE A 1 129 ? -32.315 -1.980  54.103  1.00 31.76 ? 122 PHE H CZ  1 
ATOM   996  N N   . PRO A 1 130 ? -28.731 -6.451  58.682  1.00 24.51 ? 123 PRO H N   1 
ATOM   997  C CA  . PRO A 1 130 ? -28.097 -7.653  59.252  1.00 29.18 ? 123 PRO H CA  1 
ATOM   998  C C   . PRO A 1 130 ? -28.637 -8.925  58.608  1.00 23.87 ? 123 PRO H C   1 
ATOM   999  O O   . PRO A 1 130 ? -29.811 -9.006  58.244  1.00 27.32 ? 123 PRO H O   1 
ATOM   1000 C CB  . PRO A 1 130 ? -28.475 -7.583  60.736  1.00 28.16 ? 123 PRO H CB  1 
ATOM   1001 C CG  . PRO A 1 130 ? -29.862 -6.925  60.693  1.00 32.16 ? 123 PRO H CG  1 
ATOM   1002 C CD  . PRO A 1 130 ? -29.800 -5.925  59.551  1.00 29.60 ? 123 PRO H CD  1 
ATOM   1003 N N   . LEU A 1 131 ? -27.754 -9.913  58.448  1.00 27.34 ? 124 LEU H N   1 
ATOM   1004 C CA  . LEU A 1 131 ? -28.139 -11.310 58.229  1.00 25.77 ? 124 LEU H CA  1 
ATOM   1005 C C   . LEU A 1 131 ? -27.944 -11.986 59.582  1.00 26.66 ? 124 LEU H C   1 
ATOM   1006 O O   . LEU A 1 131 ? -26.839 -12.421 59.929  1.00 22.46 ? 124 LEU H O   1 
ATOM   1007 C CB  . LEU A 1 131 ? -27.297 -11.947 57.130  1.00 24.17 ? 124 LEU H CB  1 
ATOM   1008 C CG  . LEU A 1 131 ? -27.416 -11.155 55.820  1.00 22.25 ? 124 LEU H CG  1 
ATOM   1009 C CD1 . LEU A 1 131 ? -26.370 -11.608 54.782  1.00 24.14 ? 124 LEU H CD1 1 
ATOM   1010 C CD2 . LEU A 1 131 ? -28.822 -11.226 55.255  1.00 24.13 ? 124 LEU H CD2 1 
ATOM   1011 N N   . ALA A 1 132 ? -29.017 -12.000 60.375  1.00 26.64 ? 125 ALA H N   1 
ATOM   1012 C CA  . ALA A 1 132 ? -28.929 -12.395 61.782  1.00 25.42 ? 125 ALA H CA  1 
ATOM   1013 C C   . ALA A 1 132 ? -28.737 -13.905 61.898  1.00 26.39 ? 125 ALA H C   1 
ATOM   1014 O O   . ALA A 1 132 ? -29.435 -14.657 61.220  1.00 25.34 ? 125 ALA H O   1 
ATOM   1015 C CB  . ALA A 1 132 ? -30.194 -11.990 62.525  1.00 22.39 ? 125 ALA H CB  1 
ATOM   1016 N N   . PRO A 1 133 ? -27.813 -14.373 62.738  1.00 24.97 ? 126 PRO H N   1 
ATOM   1017 C CA  . PRO A 1 133 ? -27.719 -15.822 62.979  1.00 24.33 ? 126 PRO H CA  1 
ATOM   1018 C C   . PRO A 1 133 ? -28.987 -16.356 63.645  1.00 29.10 ? 126 PRO H C   1 
ATOM   1019 O O   . PRO A 1 133 ? -29.581 -15.701 64.504  1.00 29.83 ? 126 PRO H O   1 
ATOM   1020 C CB  . PRO A 1 133 ? -26.494 -15.944 63.892  1.00 29.20 ? 126 PRO H CB  1 
ATOM   1021 C CG  . PRO A 1 133 ? -26.390 -14.606 64.574  1.00 30.93 ? 126 PRO H CG  1 
ATOM   1022 C CD  . PRO A 1 133 ? -26.903 -13.593 63.584  1.00 27.42 ? 126 PRO H CD  1 
ATOM   1023 N N   . SER A 1 134 ? -29.413 -17.547 63.214  1.00 33.85 ? 127 SER H N   1 
ATOM   1024 C CA  . SER A 1 134 ? -30.571 -18.241 63.772  1.00 27.62 ? 127 SER H CA  1 
ATOM   1025 C C   . SER A 1 134 ? -30.358 -19.737 63.609  1.00 36.70 ? 127 SER H C   1 
ATOM   1026 O O   . SER A 1 134 ? -29.327 -20.188 63.102  1.00 36.07 ? 127 SER H O   1 
ATOM   1027 C CB  . SER A 1 134 ? -31.873 -17.840 63.090  1.00 31.97 ? 127 SER H CB  1 
ATOM   1028 O OG  . SER A 1 134 ? -32.006 -18.471 61.817  1.00 32.12 ? 127 SER H OG  1 
ATOM   1029 N N   . SER A 1 135 ? -31.370 -20.514 63.994  1.00 33.09 ? 128 SER H N   1 
ATOM   1030 C CA  . SER A 1 135 ? -31.238 -21.952 63.821  1.00 35.25 ? 128 SER H CA  1 
ATOM   1031 C C   . SER A 1 135 ? -31.203 -22.357 62.354  1.00 33.44 ? 128 SER H C   1 
ATOM   1032 O O   . SER A 1 135 ? -30.855 -23.507 62.060  1.00 32.87 ? 128 SER H O   1 
ATOM   1033 C CB  . SER A 1 135 ? -32.384 -22.662 64.532  1.00 33.58 ? 128 SER H CB  1 
ATOM   1034 O OG  . SER A 1 135 ? -33.597 -22.250 63.949  1.00 30.64 ? 128 SER H OG  1 
ATOM   1035 N N   . LYS A 1 136 ? -31.559 -21.447 61.442  1.00 32.05 ? 129 LYS H N   1 
ATOM   1036 C CA  . LYS A 1 136 ? -31.469 -21.637 59.999  1.00 30.53 ? 129 LYS H CA  1 
ATOM   1037 C C   . LYS A 1 136 ? -30.100 -21.270 59.465  1.00 31.12 ? 129 LYS H C   1 
ATOM   1038 O O   . LYS A 1 136 ? -29.834 -21.437 58.267  1.00 34.67 ? 129 LYS H O   1 
ATOM   1039 C CB  . LYS A 1 136 ? -32.545 -20.805 59.276  1.00 34.28 ? 129 LYS H CB  1 
ATOM   1040 C CG  . LYS A 1 136 ? -33.976 -21.294 59.499  1.00 33.04 ? 129 LYS H CG  1 
ATOM   1041 C CD  . LYS A 1 136 ? -34.722 -20.393 60.451  1.00 47.37 ? 129 LYS H CD  1 
ATOM   1042 C CE  . LYS A 1 136 ? -35.698 -21.193 61.336  1.00 50.17 ? 129 LYS H CE  1 
ATOM   1043 N NZ  . LYS A 1 136 ? -36.318 -20.367 62.424  1.00 50.60 ? 129 LYS H NZ  1 
ATOM   1044 N N   . SER A 1 137 ? -29.221 -20.774 60.323  1.00 32.16 ? 130 SER H N   1 
ATOM   1045 C CA  . SER A 1 137 ? -27.866 -20.458 59.903  1.00 29.13 ? 130 SER H CA  1 
ATOM   1046 C C   . SER A 1 137 ? -26.839 -21.114 60.823  1.00 30.89 ? 130 SER H C   1 
ATOM   1047 O O   . SER A 1 137 ? -25.670 -20.735 60.790  1.00 31.02 ? 130 SER H O   1 
ATOM   1048 C CB  . SER A 1 137 ? -27.664 -18.937 59.839  1.00 30.30 ? 130 SER H CB  1 
ATOM   1049 O OG  . SER A 1 137 ? -27.418 -18.417 61.132  1.00 31.42 ? 130 SER H OG  1 
ATOM   1050 N N   . THR A 1 138 ? -27.251 -22.117 61.615  1.00 35.32 ? 131 THR H N   1 
ATOM   1051 C CA  . THR A 1 138 ? -26.380 -22.811 62.562  1.00 30.52 ? 131 THR H CA  1 
ATOM   1052 C C   . THR A 1 138 ? -26.120 -24.248 62.125  1.00 29.12 ? 131 THR H C   1 
ATOM   1053 O O   . THR A 1 138 ? -27.024 -24.930 61.624  1.00 30.94 ? 131 THR H O   1 
ATOM   1054 C CB  . THR A 1 138 ? -26.983 -22.813 63.968  1.00 29.16 ? 131 THR H CB  1 
ATOM   1055 O OG1 . THR A 1 138 ? -27.145 -21.461 64.396  1.00 34.80 ? 131 THR H OG1 1 
ATOM   1056 C CG2 . THR A 1 138 ? -26.061 -23.528 64.957  1.00 29.31 ? 131 THR H CG2 1 
ATOM   1057 N N   . SER A 1 139 ? -24.868 -24.693 62.301  1.00 22.63 ? 132 SER H N   1 
ATOM   1058 C CA  . SER A 1 139 ? -24.446 -26.066 62.029  1.00 27.39 ? 132 SER H CA  1 
ATOM   1059 C C   . SER A 1 139 ? -23.624 -26.573 63.207  1.00 28.98 ? 132 SER H C   1 
ATOM   1060 O O   . SER A 1 139 ? -22.388 -26.564 63.168  1.00 27.06 ? 132 SER H O   1 
ATOM   1061 C CB  . SER A 1 139 ? -23.658 -26.139 60.742  1.00 32.76 ? 132 SER H CB  1 
ATOM   1062 O OG  . SER A 1 139 ? -23.160 -27.450 60.571  1.00 37.54 ? 132 SER H OG  1 
ATOM   1063 N N   . GLY A 1 140 ? -24.307 -27.064 64.230  1.00 31.19 ? 133 GLY H N   1 
ATOM   1064 C CA  . GLY A 1 140 ? -23.591 -27.604 65.373  1.00 26.83 ? 133 GLY H CA  1 
ATOM   1065 C C   . GLY A 1 140 ? -22.760 -26.527 66.033  1.00 26.73 ? 133 GLY H C   1 
ATOM   1066 O O   . GLY A 1 140 ? -23.284 -25.523 66.539  1.00 30.11 ? 133 GLY H O   1 
ATOM   1067 N N   . GLY A 1 141 ? -21.444 -26.728 66.037  1.00 28.05 ? 134 GLY H N   1 
ATOM   1068 C CA  . GLY A 1 141 ? -20.531 -25.770 66.640  1.00 29.96 ? 134 GLY H CA  1 
ATOM   1069 C C   . GLY A 1 141 ? -20.279 -24.493 65.851  1.00 28.91 ? 134 GLY H C   1 
ATOM   1070 O O   . GLY A 1 141 ? -19.616 -23.591 66.364  1.00 29.01 ? 134 GLY H O   1 
ATOM   1071 N N   . THR A 1 142 ? -20.769 -24.385 64.619  1.00 32.06 ? 135 THR H N   1 
ATOM   1072 C CA  . THR A 1 142 ? -20.574 -23.178 63.818  1.00 29.26 ? 135 THR H CA  1 
ATOM   1073 C C   . THR A 1 142 ? -21.914 -22.526 63.480  1.00 28.47 ? 135 THR H C   1 
ATOM   1074 O O   . THR A 1 142 ? -22.935 -23.202 63.309  1.00 28.94 ? 135 THR H O   1 
ATOM   1075 C CB  . THR A 1 142 ? -19.806 -23.496 62.524  1.00 28.96 ? 135 THR H CB  1 
ATOM   1076 O OG1 . THR A 1 142 ? -18.593 -24.154 62.862  1.00 36.87 ? 135 THR H OG1 1 
ATOM   1077 C CG2 . THR A 1 142 ? -19.433 -22.210 61.787  1.00 40.63 ? 135 THR H CG2 1 
ATOM   1078 N N   . ALA A 1 143 ? -21.913 -21.197 63.393  1.00 27.24 ? 136 ALA H N   1 
ATOM   1079 C CA  . ALA A 1 143 ? -23.090 -20.470 62.943  1.00 26.98 ? 136 ALA H CA  1 
ATOM   1080 C C   . ALA A 1 143 ? -22.647 -19.405 61.950  1.00 25.55 ? 136 ALA H C   1 
ATOM   1081 O O   . ALA A 1 143 ? -21.539 -18.863 62.051  1.00 23.51 ? 136 ALA H O   1 
ATOM   1082 C CB  . ALA A 1 143 ? -23.848 -19.841 64.114  1.00 25.30 ? 136 ALA H CB  1 
ATOM   1083 N N   . ALA A 1 144 ? -23.512 -19.118 60.984  1.00 20.69 ? 137 ALA H N   1 
ATOM   1084 C CA  . ALA A 1 144 ? -23.213 -18.104 59.978  1.00 24.84 ? 137 ALA H CA  1 
ATOM   1085 C C   . ALA A 1 144 ? -23.993 -16.815 60.247  1.00 25.12 ? 137 ALA H C   1 
ATOM   1086 O O   . ALA A 1 144 ? -25.137 -16.830 60.707  1.00 25.87 ? 137 ALA H O   1 
ATOM   1087 C CB  . ALA A 1 144 ? -23.519 -18.616 58.570  1.00 24.79 ? 137 ALA H CB  1 
ATOM   1088 N N   . LEU A 1 145 ? -23.360 -15.693 59.941  1.00 24.82 ? 138 LEU H N   1 
ATOM   1089 C CA  . LEU A 1 145 ? -23.999 -14.392 60.083  1.00 26.07 ? 138 LEU H CA  1 
ATOM   1090 C C   . LEU A 1 145 ? -23.302 -13.438 59.120  1.00 25.30 ? 138 LEU H C   1 
ATOM   1091 O O   . LEU A 1 145 ? -22.203 -13.716 58.629  1.00 26.37 ? 138 LEU H O   1 
ATOM   1092 C CB  . LEU A 1 145 ? -23.932 -13.887 61.532  1.00 23.13 ? 138 LEU H CB  1 
ATOM   1093 C CG  . LEU A 1 145 ? -22.516 -13.594 62.055  1.00 28.79 ? 138 LEU H CG  1 
ATOM   1094 C CD1 . LEU A 1 145 ? -22.158 -12.086 62.104  1.00 24.51 ? 138 LEU H CD1 1 
ATOM   1095 C CD2 . LEU A 1 145 ? -22.333 -14.199 63.412  1.00 32.18 ? 138 LEU H CD2 1 
ATOM   1096 N N   . GLY A 1 146 ? -23.939 -12.302 58.868  1.00 26.47 ? 139 GLY H N   1 
ATOM   1097 C CA  . GLY A 1 146 ? -23.377 -11.393 57.892  1.00 25.61 ? 139 GLY H CA  1 
ATOM   1098 C C   . GLY A 1 146 ? -24.123 -10.079 57.805  1.00 25.06 ? 139 GLY H C   1 
ATOM   1099 O O   . GLY A 1 146 ? -24.919 -9.731  58.676  1.00 26.26 ? 139 GLY H O   1 
ATOM   1100 N N   . CYS A 1 147 ? -23.835 -9.340  56.731  1.00 21.74 ? 140 CYS H N   1 
ATOM   1101 C CA  . CYS A 1 147 ? -24.490 -8.068  56.433  1.00 23.47 ? 140 CYS H CA  1 
ATOM   1102 C C   . CYS A 1 147 ? -24.877 -8.040  54.966  1.00 23.80 ? 140 CYS H C   1 
ATOM   1103 O O   . CYS A 1 147 ? -24.120 -8.511  54.109  1.00 25.64 ? 140 CYS H O   1 
ATOM   1104 C CB  . CYS A 1 147 ? -23.578 -6.874  56.721  1.00 28.62 ? 140 CYS H CB  1 
ATOM   1105 S SG  . CYS A 1 147 ? -23.379 -6.515  58.462  1.00 39.11 ? 140 CYS H SG  1 
ATOM   1106 N N   . LEU A 1 148 ? -26.057 -7.513  54.683  1.00 21.48 ? 141 LEU H N   1 
ATOM   1107 C CA  . LEU A 1 148 ? -26.504 -7.294  53.314  1.00 26.44 ? 141 LEU H CA  1 
ATOM   1108 C C   . LEU A 1 148 ? -26.319 -5.806  53.006  1.00 28.40 ? 141 LEU H C   1 
ATOM   1109 O O   . LEU A 1 148 ? -26.920 -4.955  53.676  1.00 22.85 ? 141 LEU H O   1 
ATOM   1110 C CB  . LEU A 1 148 ? -27.961 -7.723  53.155  1.00 24.42 ? 141 LEU H CB  1 
ATOM   1111 C CG  . LEU A 1 148 ? -28.592 -7.518  51.779  1.00 29.09 ? 141 LEU H CG  1 
ATOM   1112 C CD1 . LEU A 1 148 ? -27.824 -8.232  50.678  1.00 23.93 ? 141 LEU H CD1 1 
ATOM   1113 C CD2 . LEU A 1 148 ? -30.027 -7.963  51.810  1.00 22.98 ? 141 LEU H CD2 1 
ATOM   1114 N N   . VAL A 1 149 ? -25.462 -5.495  52.036  1.00 27.78 ? 142 VAL H N   1 
ATOM   1115 C CA  . VAL A 1 149 ? -25.080 -4.107  51.725  1.00 26.70 ? 142 VAL H CA  1 
ATOM   1116 C C   . VAL A 1 149 ? -25.829 -3.734  50.449  1.00 25.22 ? 142 VAL H C   1 
ATOM   1117 O O   . VAL A 1 149 ? -25.335 -3.929  49.334  1.00 26.12 ? 142 VAL H O   1 
ATOM   1118 C CB  . VAL A 1 149 ? -23.565 -3.961  51.580  1.00 26.56 ? 142 VAL H CB  1 
ATOM   1119 C CG1 . VAL A 1 149 ? -23.164 -2.514  51.206  1.00 26.74 ? 142 VAL H CG1 1 
ATOM   1120 C CG2 . VAL A 1 149 ? -22.866 -4.426  52.850  1.00 23.44 ? 142 VAL H CG2 1 
ATOM   1121 N N   . LYS A 1 150 ? -27.024 -3.162  50.605  1.00 23.93 ? 143 LYS H N   1 
ATOM   1122 C CA  . LYS A 1 150 ? -27.992 -3.072  49.514  1.00 25.93 ? 143 LYS H CA  1 
ATOM   1123 C C   . LYS A 1 150 ? -28.084 -1.659  48.945  1.00 29.76 ? 143 LYS H C   1 
ATOM   1124 O O   . LYS A 1 150 ? -27.990 -0.675  49.690  1.00 26.06 ? 143 LYS H O   1 
ATOM   1125 C CB  . LYS A 1 150 ? -29.382 -3.517  49.980  1.00 25.62 ? 143 LYS H CB  1 
ATOM   1126 C CG  . LYS A 1 150 ? -30.408 -3.528  48.846  1.00 32.87 ? 143 LYS H CG  1 
ATOM   1127 C CD  . LYS A 1 150 ? -31.514 -4.532  49.039  1.00 33.43 ? 143 LYS H CD  1 
ATOM   1128 C CE  . LYS A 1 150 ? -32.242 -4.804  47.711  1.00 34.84 ? 143 LYS H CE  1 
ATOM   1129 N NZ  . LYS A 1 150 ? -33.139 -3.685  47.298  1.00 35.48 ? 143 LYS H NZ  1 
ATOM   1130 N N   . ASP A 1 151 ? -28.269 -1.576  47.614  1.00 23.79 ? 144 ASP H N   1 
ATOM   1131 C CA  . ASP A 1 151 ? -28.679 -0.352  46.914  1.00 25.86 ? 144 ASP H CA  1 
ATOM   1132 C C   . ASP A 1 151 ? -27.675 0.787   47.105  1.00 29.00 ? 144 ASP H C   1 
ATOM   1133 O O   . ASP A 1 151 ? -27.977 1.820   47.699  1.00 26.99 ? 144 ASP H O   1 
ATOM   1134 C CB  . ASP A 1 151 ? -30.073 0.089   47.366  1.00 27.55 ? 144 ASP H CB  1 
ATOM   1135 C CG  . ASP A 1 151 ? -31.154 -0.855  46.908  1.00 28.22 ? 144 ASP H CG  1 
ATOM   1136 O OD1 . ASP A 1 151 ? -30.879 -1.715  46.044  1.00 30.65 ? 144 ASP H OD1 1 
ATOM   1137 O OD2 . ASP A 1 151 ? -32.279 -0.749  47.417  1.00 32.15 ? 144 ASP H OD2 1 
ATOM   1138 N N   . TYR A 1 152 ? -26.467 0.592   46.587  1.00 20.46 ? 145 TYR H N   1 
ATOM   1139 C CA  . TYR A 1 152 ? -25.477 1.652   46.606  1.00 21.45 ? 145 TYR H CA  1 
ATOM   1140 C C   . TYR A 1 152 ? -24.994 1.904   45.186  1.00 28.53 ? 145 TYR H C   1 
ATOM   1141 O O   . TYR A 1 152 ? -25.188 1.084   44.281  1.00 27.12 ? 145 TYR H O   1 
ATOM   1142 C CB  . TYR A 1 152 ? -24.298 1.331   47.537  1.00 19.88 ? 145 TYR H CB  1 
ATOM   1143 C CG  . TYR A 1 152 ? -23.463 0.162   47.086  1.00 29.26 ? 145 TYR H CG  1 
ATOM   1144 C CD1 . TYR A 1 152 ? -22.384 0.337   46.216  1.00 22.81 ? 145 TYR H CD1 1 
ATOM   1145 C CD2 . TYR A 1 152 ? -23.753 -1.126  47.527  1.00 26.36 ? 145 TYR H CD2 1 
ATOM   1146 C CE1 . TYR A 1 152 ? -21.629 -0.744  45.789  1.00 25.70 ? 145 TYR H CE1 1 
ATOM   1147 C CE2 . TYR A 1 152 ? -22.999 -2.206  47.119  1.00 27.30 ? 145 TYR H CE2 1 
ATOM   1148 C CZ  . TYR A 1 152 ? -21.946 -2.020  46.248  1.00 28.23 ? 145 TYR H CZ  1 
ATOM   1149 O OH  . TYR A 1 152 ? -21.202 -3.113  45.855  1.00 27.82 ? 145 TYR H OH  1 
ATOM   1150 N N   . PHE A 1 153 ? -24.372 3.065   44.989  1.00 24.76 ? 146 PHE H N   1 
ATOM   1151 C CA  . PHE A 1 153 ? -23.857 3.372   43.664  1.00 25.72 ? 146 PHE H CA  1 
ATOM   1152 C C   . PHE A 1 153 ? -22.830 4.472   43.799  1.00 24.58 ? 146 PHE H C   1 
ATOM   1153 O O   . PHE A 1 153 ? -23.023 5.386   44.612  1.00 26.28 ? 146 PHE H O   1 
ATOM   1154 C CB  . PHE A 1 153 ? -24.976 3.802   42.702  1.00 25.70 ? 146 PHE H CB  1 
ATOM   1155 C CG  . PHE A 1 153 ? -24.484 4.240   41.350  1.00 27.89 ? 146 PHE H CG  1 
ATOM   1156 C CD1 . PHE A 1 153 ? -24.346 3.325   40.323  1.00 24.64 ? 146 PHE H CD1 1 
ATOM   1157 C CD2 . PHE A 1 153 ? -24.172 5.579   41.103  1.00 23.24 ? 146 PHE H CD2 1 
ATOM   1158 C CE1 . PHE A 1 153 ? -23.885 3.717   39.071  1.00 26.15 ? 146 PHE H CE1 1 
ATOM   1159 C CE2 . PHE A 1 153 ? -23.719 5.974   39.856  1.00 24.06 ? 146 PHE H CE2 1 
ATOM   1160 C CZ  . PHE A 1 153 ? -23.584 5.040   38.837  1.00 27.50 ? 146 PHE H CZ  1 
ATOM   1161 N N   . PRO A 1 154 ? -21.724 4.402   43.073  1.00 24.28 ? 147 PRO H N   1 
ATOM   1162 C CA  . PRO A 1 154 ? -21.266 3.290   42.241  1.00 24.44 ? 147 PRO H CA  1 
ATOM   1163 C C   . PRO A 1 154 ? -20.451 2.300   43.078  1.00 24.17 ? 147 PRO H C   1 
ATOM   1164 O O   . PRO A 1 154 ? -20.360 2.459   44.294  1.00 24.25 ? 147 PRO H O   1 
ATOM   1165 C CB  . PRO A 1 154 ? -20.395 4.011   41.202  1.00 21.28 ? 147 PRO H CB  1 
ATOM   1166 C CG  . PRO A 1 154 ? -19.684 5.019   42.082  1.00 23.04 ? 147 PRO H CG  1 
ATOM   1167 C CD  . PRO A 1 154 ? -20.780 5.537   43.004  1.00 21.97 ? 147 PRO H CD  1 
ATOM   1168 N N   . GLU A 1 155 ? -19.839 1.291   42.434  1.00 24.95 ? 148 GLU H N   1 
ATOM   1169 C CA  . GLU A 1 155 ? -18.773 0.500   43.044  1.00 23.37 ? 148 GLU H CA  1 
ATOM   1170 C C   . GLU A 1 155 ? -17.589 1.401   43.401  1.00 26.48 ? 148 GLU H C   1 
ATOM   1171 O O   . GLU A 1 155 ? -17.421 2.474   42.818  1.00 23.67 ? 148 GLU H O   1 
ATOM   1172 C CB  . GLU A 1 155 ? -18.312 -0.584  42.074  1.00 24.76 ? 148 GLU H CB  1 
ATOM   1173 C CG  . GLU A 1 155 ? -19.332 -1.640  41.807  1.00 25.13 ? 148 GLU H CG  1 
ATOM   1174 C CD  . GLU A 1 155 ? -19.233 -2.750  42.815  1.00 32.10 ? 148 GLU H CD  1 
ATOM   1175 O OE1 . GLU A 1 155 ? -19.411 -2.463  44.031  1.00 29.81 ? 148 GLU H OE1 1 
ATOM   1176 O OE2 . GLU A 1 155 ? -18.941 -3.894  42.385  1.00 31.45 ? 148 GLU H OE2 1 
ATOM   1177 N N   . PRO A 1 156 ? -16.741 0.981   44.359  1.00 23.86 ? 149 PRO H N   1 
ATOM   1178 C CA  . PRO A 1 156 ? -16.798 -0.258  45.129  1.00 24.98 ? 149 PRO H CA  1 
ATOM   1179 C C   . PRO A 1 156 ? -17.180 -0.012  46.581  1.00 26.03 ? 149 PRO H C   1 
ATOM   1180 O O   . PRO A 1 156 ? -17.162 1.144   47.022  1.00 26.03 ? 149 PRO H O   1 
ATOM   1181 C CB  . PRO A 1 156 ? -15.362 -0.762  45.003  1.00 23.72 ? 149 PRO H CB  1 
ATOM   1182 C CG  . PRO A 1 156 ? -14.575 0.504   45.182  1.00 23.26 ? 149 PRO H CG  1 
ATOM   1183 C CD  . PRO A 1 156 ? -15.401 1.584   44.475  1.00 24.30 ? 149 PRO H CD  1 
ATOM   1184 N N   . VAL A 1 157 ? -17.524 -1.055  47.342  1.00 25.67 ? 150 VAL H N   1 
ATOM   1185 C CA  . VAL A 1 157 ? -17.566 -0.987  48.798  1.00 23.85 ? 150 VAL H CA  1 
ATOM   1186 C C   . VAL A 1 157 ? -16.572 -1.998  49.334  1.00 29.77 ? 150 VAL H C   1 
ATOM   1187 O O   . VAL A 1 157 ? -16.245 -2.985  48.671  1.00 31.15 ? 150 VAL H O   1 
ATOM   1188 C CB  . VAL A 1 157 ? -18.969 -1.257  49.397  1.00 28.47 ? 150 VAL H CB  1 
ATOM   1189 C CG1 . VAL A 1 157 ? -19.947 -0.238  48.933  1.00 28.79 ? 150 VAL H CG1 1 
ATOM   1190 C CG2 . VAL A 1 157 ? -19.457 -2.605  48.994  1.00 30.39 ? 150 VAL H CG2 1 
ATOM   1191 N N   . THR A 1 158 ? -16.051 -1.724  50.522  1.00 30.59 ? 151 THR H N   1 
ATOM   1192 C CA  . THR A 1 158 ? -15.234 -2.678  51.255  1.00 28.28 ? 151 THR H CA  1 
ATOM   1193 C C   . THR A 1 158 ? -15.955 -3.007  52.553  1.00 29.54 ? 151 THR H C   1 
ATOM   1194 O O   . THR A 1 158 ? -16.654 -2.158  53.113  1.00 25.43 ? 151 THR H O   1 
ATOM   1195 C CB  . THR A 1 158 ? -13.843 -2.126  51.567  1.00 30.41 ? 151 THR H CB  1 
ATOM   1196 O OG1 . THR A 1 158 ? -13.969 -0.949  52.363  1.00 31.50 ? 151 THR H OG1 1 
ATOM   1197 C CG2 . THR A 1 158 ? -13.113 -1.782  50.303  1.00 30.23 ? 151 THR H CG2 1 
ATOM   1198 N N   . VAL A 1 159 ? -15.781 -4.246  53.025  1.00 28.36 ? 152 VAL H N   1 
ATOM   1199 C CA  . VAL A 1 159 ? -16.362 -4.705  54.277  1.00 25.63 ? 152 VAL H CA  1 
ATOM   1200 C C   . VAL A 1 159 ? -15.250 -5.297  55.132  1.00 30.71 ? 152 VAL H C   1 
ATOM   1201 O O   . VAL A 1 159 ? -14.478 -6.145  54.661  1.00 28.60 ? 152 VAL H O   1 
ATOM   1202 C CB  . VAL A 1 159 ? -17.478 -5.746  54.050  1.00 25.83 ? 152 VAL H CB  1 
ATOM   1203 C CG1 . VAL A 1 159 ? -18.125 -6.141  55.390  1.00 23.15 ? 152 VAL H CG1 1 
ATOM   1204 C CG2 . VAL A 1 159 ? -18.531 -5.220  53.065  1.00 26.61 ? 152 VAL H CG2 1 
ATOM   1205 N N   . SER A 1 160 ? -15.157 -4.845  56.380  1.00 24.58 ? 153 SER H N   1 
ATOM   1206 C CA  . SER A 1 160 ? -14.399 -5.550  57.400  1.00 28.15 ? 153 SER H CA  1 
ATOM   1207 C C   . SER A 1 160 ? -15.367 -6.026  58.478  1.00 29.32 ? 153 SER H C   1 
ATOM   1208 O O   . SER A 1 160 ? -16.567 -5.718  58.456  1.00 29.97 ? 153 SER H O   1 
ATOM   1209 C CB  . SER A 1 160 ? -13.308 -4.665  58.006  1.00 30.85 ? 153 SER H CB  1 
ATOM   1210 O OG  . SER A 1 160 ? -13.907 -3.557  58.666  1.00 31.25 ? 153 SER H OG  1 
ATOM   1211 N N   . TRP A 1 161 ? -14.842 -6.801  59.418  1.00 28.08 ? 154 TRP H N   1 
ATOM   1212 C CA  . TRP A 1 161 ? -15.631 -7.295  60.544  1.00 28.49 ? 154 TRP H CA  1 
ATOM   1213 C C   . TRP A 1 161 ? -14.867 -7.007  61.817  1.00 25.90 ? 154 TRP H C   1 
ATOM   1214 O O   . TRP A 1 161 ? -13.671 -7.309  61.905  1.00 29.84 ? 154 TRP H O   1 
ATOM   1215 C CB  . TRP A 1 161 ? -15.922 -8.801  60.427  1.00 30.94 ? 154 TRP H CB  1 
ATOM   1216 C CG  . TRP A 1 161 ? -17.008 -9.087  59.455  1.00 22.93 ? 154 TRP H CG  1 
ATOM   1217 C CD1 . TRP A 1 161 ? -16.867 -9.293  58.123  1.00 22.22 ? 154 TRP H CD1 1 
ATOM   1218 C CD2 . TRP A 1 161 ? -18.402 -9.165  59.735  1.00 24.45 ? 154 TRP H CD2 1 
ATOM   1219 N NE1 . TRP A 1 161 ? -18.089 -9.502  57.543  1.00 23.54 ? 154 TRP H NE1 1 
ATOM   1220 C CE2 . TRP A 1 161 ? -19.053 -9.427  58.518  1.00 21.03 ? 154 TRP H CE2 1 
ATOM   1221 C CE3 . TRP A 1 161 ? -19.169 -9.044  60.904  1.00 23.98 ? 154 TRP H CE3 1 
ATOM   1222 C CZ2 . TRP A 1 161 ? -20.437 -9.584  58.427  1.00 24.22 ? 154 TRP H CZ2 1 
ATOM   1223 C CZ3 . TRP A 1 161 ? -20.541 -9.196  60.812  1.00 27.94 ? 154 TRP H CZ3 1 
ATOM   1224 C CH2 . TRP A 1 161 ? -21.164 -9.463  59.577  1.00 26.53 ? 154 TRP H CH2 1 
ATOM   1225 N N   . ASN A 1 162 ? -15.554 -6.414  62.786  1.00 30.11 ? 155 ASN H N   1 
ATOM   1226 C CA  . ASN A 1 162 ? -14.949 -6.044  64.065  1.00 32.13 ? 155 ASN H CA  1 
ATOM   1227 C C   . ASN A 1 162 ? -13.683 -5.219  63.843  1.00 33.57 ? 155 ASN H C   1 
ATOM   1228 O O   . ASN A 1 162 ? -12.620 -5.473  64.417  1.00 34.65 ? 155 ASN H O   1 
ATOM   1229 C CB  . ASN A 1 162 ? -14.697 -7.288  64.915  1.00 32.67 ? 155 ASN H CB  1 
ATOM   1230 C CG  . ASN A 1 162 ? -15.995 -7.901  65.410  1.00 32.38 ? 155 ASN H CG  1 
ATOM   1231 O OD1 . ASN A 1 162 ? -17.075 -7.369  65.141  1.00 37.91 ? 155 ASN H OD1 1 
ATOM   1232 N ND2 . ASN A 1 162 ? -15.906 -9.011  66.122  1.00 35.14 ? 155 ASN H ND2 1 
ATOM   1233 N N   . SER A 1 163 ? -13.815 -4.216  62.971  1.00 33.64 ? 156 SER H N   1 
ATOM   1234 C CA  . SER A 1 163 ? -12.715 -3.310  62.628  1.00 35.63 ? 156 SER H CA  1 
ATOM   1235 C C   . SER A 1 163 ? -11.479 -4.079  62.166  1.00 35.54 ? 156 SER H C   1 
ATOM   1236 O O   . SER A 1 163 ? -10.343 -3.647  62.365  1.00 34.19 ? 156 SER H O   1 
ATOM   1237 C CB  . SER A 1 163 ? -12.391 -2.377  63.793  1.00 33.53 ? 156 SER H CB  1 
ATOM   1238 O OG  . SER A 1 163 ? -13.476 -1.483  64.007  1.00 37.82 ? 156 SER H OG  1 
ATOM   1239 N N   . GLY A 1 164 ? -11.700 -5.214  61.510  1.00 32.13 ? 157 GLY H N   1 
ATOM   1240 C CA  . GLY A 1 164 ? -10.613 -5.965  60.932  1.00 35.03 ? 157 GLY H CA  1 
ATOM   1241 C C   . GLY A 1 164 ? -9.987  -6.974  61.855  1.00 36.67 ? 157 GLY H C   1 
ATOM   1242 O O   . GLY A 1 164 ? -9.057  -7.673  61.436  1.00 36.05 ? 157 GLY H O   1 
ATOM   1243 N N   . ALA A 1 165 ? -10.454 -7.070  63.098  1.00 35.11 ? 158 ALA H N   1 
ATOM   1244 C CA  . ALA A 1 165 ? -9.976  -8.121  63.985  1.00 36.19 ? 158 ALA H CA  1 
ATOM   1245 C C   . ALA A 1 165 ? -10.611 -9.472  63.675  1.00 35.89 ? 158 ALA H C   1 
ATOM   1246 O O   . ALA A 1 165 ? -10.126 -10.495 64.166  1.00 40.81 ? 158 ALA H O   1 
ATOM   1247 C CB  . ALA A 1 165 ? -10.241 -7.741  65.444  1.00 31.24 ? 158 ALA H CB  1 
ATOM   1248 N N   . LEU A 1 166 ? -11.671 -9.501  62.875  1.00 38.75 ? 159 LEU H N   1 
ATOM   1249 C CA  . LEU A 1 166 ? -12.360 -10.733 62.494  1.00 31.14 ? 159 LEU H CA  1 
ATOM   1250 C C   . LEU A 1 166 ? -12.057 -10.981 61.019  1.00 32.38 ? 159 LEU H C   1 
ATOM   1251 O O   . LEU A 1 166 ? -12.604 -10.303 60.142  1.00 31.38 ? 159 LEU H O   1 
ATOM   1252 C CB  . LEU A 1 166 ? -13.857 -10.614 62.760  1.00 29.59 ? 159 LEU H CB  1 
ATOM   1253 C CG  . LEU A 1 166 ? -14.673 -11.889 62.519  1.00 30.98 ? 159 LEU H CG  1 
ATOM   1254 C CD1 . LEU A 1 166 ? -14.101 -13.055 63.319  1.00 33.73 ? 159 LEU H CD1 1 
ATOM   1255 C CD2 . LEU A 1 166 ? -16.102 -11.667 62.913  1.00 34.63 ? 159 LEU H CD2 1 
ATOM   1256 N N   . THR A 1 167 ? -11.168 -11.940 60.745  1.00 33.28 ? 160 THR H N   1 
ATOM   1257 C CA  . THR A 1 167 ? -10.827 -12.304 59.377  1.00 31.17 ? 160 THR H CA  1 
ATOM   1258 C C   . THR A 1 167 ? -11.038 -13.776 59.063  1.00 39.65 ? 160 THR H C   1 
ATOM   1259 O O   . THR A 1 167 ? -11.397 -14.098 57.927  1.00 34.79 ? 160 THR H O   1 
ATOM   1260 C CB  . THR A 1 167 ? -9.371  -11.938 59.062  1.00 37.06 ? 160 THR H CB  1 
ATOM   1261 O OG1 . THR A 1 167 ? -8.491  -12.615 59.977  1.00 38.96 ? 160 THR H OG1 1 
ATOM   1262 C CG2 . THR A 1 167 ? -9.183  -10.423 59.197  1.00 36.53 ? 160 THR H CG2 1 
ATOM   1263 N N   . SER A 1 168 ? -10.832 -14.676 60.022  1.00 33.94 ? 161 SER H N   1 
ATOM   1264 C CA  . SER A 1 168 ? -11.079 -16.087 59.765  1.00 38.96 ? 161 SER H CA  1 
ATOM   1265 C C   . SER A 1 168 ? -12.530 -16.324 59.332  1.00 31.91 ? 161 SER H C   1 
ATOM   1266 O O   . SER A 1 168 ? -13.470 -15.844 59.967  1.00 36.59 ? 161 SER H O   1 
ATOM   1267 C CB  . SER A 1 168 ? -10.744 -16.898 61.018  1.00 38.00 ? 161 SER H CB  1 
ATOM   1268 O OG  . SER A 1 168 ? -11.445 -18.134 61.015  1.00 51.15 ? 161 SER H OG  1 
ATOM   1269 N N   . GLY A 1 169 ? -12.712 -17.047 58.231  1.00 29.24 ? 162 GLY H N   1 
ATOM   1270 C CA  . GLY A 1 169 ? -14.043 -17.435 57.807  1.00 36.09 ? 162 GLY H CA  1 
ATOM   1271 C C   . GLY A 1 169 ? -14.919 -16.346 57.218  1.00 32.68 ? 162 GLY H C   1 
ATOM   1272 O O   . GLY A 1 169 ? -16.123 -16.571 57.058  1.00 29.04 ? 162 GLY H O   1 
ATOM   1273 N N   . VAL A 1 170 ? -14.372 -15.172 56.904  1.00 29.95 ? 163 VAL H N   1 
ATOM   1274 C CA  . VAL A 1 170 ? -15.152 -14.118 56.251  1.00 29.85 ? 163 VAL H CA  1 
ATOM   1275 C C   . VAL A 1 170 ? -15.215 -14.388 54.754  1.00 29.20 ? 163 VAL H C   1 
ATOM   1276 O O   . VAL A 1 170 ? -14.191 -14.652 54.117  1.00 34.88 ? 163 VAL H O   1 
ATOM   1277 C CB  . VAL A 1 170 ? -14.540 -12.733 56.521  1.00 27.27 ? 163 VAL H CB  1 
ATOM   1278 C CG1 . VAL A 1 170 ? -15.249 -11.678 55.694  1.00 24.00 ? 163 VAL H CG1 1 
ATOM   1279 C CG2 . VAL A 1 170 ? -14.602 -12.405 58.004  1.00 25.78 ? 163 VAL H CG2 1 
ATOM   1280 N N   . HIS A 1 171 ? -16.408 -14.306 54.178  1.00 25.01 ? 164 HIS H N   1 
ATOM   1281 C CA  . HIS A 1 171 ? -16.552 -14.298 52.726  1.00 31.80 ? 164 HIS H CA  1 
ATOM   1282 C C   . HIS A 1 171 ? -17.297 -13.033 52.322  1.00 28.70 ? 164 HIS H C   1 
ATOM   1283 O O   . HIS A 1 171 ? -18.449 -12.845 52.710  1.00 26.24 ? 164 HIS H O   1 
ATOM   1284 C CB  . HIS A 1 171 ? -17.306 -15.538 52.224  1.00 31.91 ? 164 HIS H CB  1 
ATOM   1285 C CG  . HIS A 1 171 ? -16.525 -16.813 52.314  1.00 35.22 ? 164 HIS H CG  1 
ATOM   1286 N ND1 . HIS A 1 171 ? -15.319 -17.001 51.669  1.00 38.05 ? 164 HIS H ND1 1 
ATOM   1287 C CD2 . HIS A 1 171 ? -16.798 -17.979 52.948  1.00 38.92 ? 164 HIS H CD2 1 
ATOM   1288 C CE1 . HIS A 1 171 ? -14.878 -18.224 51.913  1.00 34.66 ? 164 HIS H CE1 1 
ATOM   1289 N NE2 . HIS A 1 171 ? -15.757 -18.837 52.685  1.00 31.33 ? 164 HIS H NE2 1 
ATOM   1290 N N   . THR A 1 172 ? -16.644 -12.163 51.558  1.00 29.43 ? 165 THR H N   1 
ATOM   1291 C CA  . THR A 1 172 ? -17.296 -10.981 51.010  1.00 28.81 ? 165 THR H CA  1 
ATOM   1292 C C   . THR A 1 172 ? -17.487 -11.197 49.513  1.00 26.66 ? 165 THR H C   1 
ATOM   1293 O O   . THR A 1 172 ? -16.514 -11.395 48.782  1.00 26.73 ? 165 THR H O   1 
ATOM   1294 C CB  . THR A 1 172 ? -16.485 -9.714  51.298  1.00 28.81 ? 165 THR H CB  1 
ATOM   1295 O OG1 . THR A 1 172 ? -16.395 -9.521  52.716  1.00 27.79 ? 165 THR H OG1 1 
ATOM   1296 C CG2 . THR A 1 172 ? -17.168 -8.496  50.685  1.00 23.55 ? 165 THR H CG2 1 
ATOM   1297 N N   . PHE A 1 173 ? -18.696 -11.186 49.080  1.00 29.75 ? 166 PHE H N   1 
ATOM   1298 C CA  . PHE A 1 173 ? -19.044 -11.582 47.723  1.00 24.92 ? 166 PHE H CA  1 
ATOM   1299 C C   . PHE A 1 173 ? -19.024 -10.412 46.746  1.00 31.77 ? 166 PHE H C   1 
ATOM   1300 O O   . PHE A 1 173 ? -19.313 -9.274  47.122  1.00 28.91 ? 166 PHE H O   1 
ATOM   1301 C CB  . PHE A 1 173 ? -20.414 -12.207 47.707  1.00 24.66 ? 166 PHE H CB  1 
ATOM   1302 C CG  . PHE A 1 173 ? -20.468 -13.476 48.466  1.00 27.70 ? 166 PHE H CG  1 
ATOM   1303 C CD1 . PHE A 1 173 ? -20.166 -14.672 47.847  1.00 26.49 ? 166 PHE H CD1 1 
ATOM   1304 C CD2 . PHE A 1 173 ? -20.776 -13.473 49.820  1.00 29.84 ? 166 PHE H CD2 1 
ATOM   1305 C CE1 . PHE A 1 173 ? -20.190 -15.849 48.564  1.00 28.47 ? 166 PHE H CE1 1 
ATOM   1306 C CE2 . PHE A 1 173 ? -20.815 -14.648 50.531  1.00 29.60 ? 166 PHE H CE2 1 
ATOM   1307 C CZ  . PHE A 1 173 ? -20.520 -15.828 49.907  1.00 25.58 ? 166 PHE H CZ  1 
ATOM   1308 N N   . PRO A 1 174 ? -18.731 -10.699 45.479  1.00 31.41 ? 167 PRO H N   1 
ATOM   1309 C CA  . PRO A 1 174 ? -18.866 -9.674  44.442  1.00 27.99 ? 167 PRO H CA  1 
ATOM   1310 C C   . PRO A 1 174 ? -20.276 -9.092  44.419  1.00 27.93 ? 167 PRO H C   1 
ATOM   1311 O O   . PRO A 1 174 ? -21.275 -9.797  44.605  1.00 25.07 ? 167 PRO H O   1 
ATOM   1312 C CB  . PRO A 1 174 ? -18.542 -10.433 43.152  1.00 29.77 ? 167 PRO H CB  1 
ATOM   1313 C CG  . PRO A 1 174 ? -17.660 -11.571 43.590  1.00 26.52 ? 167 PRO H CG  1 
ATOM   1314 C CD  . PRO A 1 174 ? -18.214 -11.973 44.942  1.00 30.28 ? 167 PRO H CD  1 
ATOM   1315 N N   . ALA A 1 175 ? -20.350 -7.775  44.223  1.00 23.47 ? 168 ALA H N   1 
ATOM   1316 C CA  . ALA A 1 175 ? -21.650 -7.137  44.091  1.00 25.66 ? 168 ALA H CA  1 
ATOM   1317 C C   . ALA A 1 175 ? -22.356 -7.640  42.850  1.00 26.19 ? 168 ALA H C   1 
ATOM   1318 O O   . ALA A 1 175 ? -21.726 -8.032  41.869  1.00 23.77 ? 168 ALA H O   1 
ATOM   1319 C CB  . ALA A 1 175 ? -21.516 -5.612  43.996  1.00 24.71 ? 168 ALA H CB  1 
ATOM   1320 N N   . VAL A 1 176 ? -23.683 -7.582  42.884  1.00 21.83 ? 169 VAL H N   1 
ATOM   1321 C CA  . VAL A 1 176 ? -24.492 -7.751  41.686  1.00 26.64 ? 169 VAL H CA  1 
ATOM   1322 C C   . VAL A 1 176 ? -25.134 -6.408  41.349  1.00 28.90 ? 169 VAL H C   1 
ATOM   1323 O O   . VAL A 1 176 ? -25.361 -5.569  42.232  1.00 27.10 ? 169 VAL H O   1 
ATOM   1324 C CB  . VAL A 1 176 ? -25.551 -8.859  41.864  1.00 26.34 ? 169 VAL H CB  1 
ATOM   1325 C CG1 . VAL A 1 176 ? -24.856 -10.170 42.182  1.00 27.83 ? 169 VAL H CG1 1 
ATOM   1326 C CG2 . VAL A 1 176 ? -26.543 -8.507  42.979  1.00 28.85 ? 169 VAL H CG2 1 
ATOM   1327 N N   . LEU A 1 177 ? -25.417 -6.205  40.056  1.00 29.99 ? 170 LEU H N   1 
ATOM   1328 C CA  . LEU A 1 177 ? -26.034 -4.975  39.550  1.00 27.29 ? 170 LEU H CA  1 
ATOM   1329 C C   . LEU A 1 177 ? -27.525 -5.232  39.335  1.00 27.73 ? 170 LEU H C   1 
ATOM   1330 O O   . LEU A 1 177 ? -27.912 -6.045  38.483  1.00 21.93 ? 170 LEU H O   1 
ATOM   1331 C CB  . LEU A 1 177 ? -25.353 -4.525  38.254  1.00 21.14 ? 170 LEU H CB  1 
ATOM   1332 C CG  . LEU A 1 177 ? -25.853 -3.267  37.537  1.00 28.28 ? 170 LEU H CG  1 
ATOM   1333 C CD1 . LEU A 1 177 ? -26.072 -2.106  38.492  1.00 23.69 ? 170 LEU H CD1 1 
ATOM   1334 C CD2 . LEU A 1 177 ? -24.834 -2.861  36.475  1.00 32.11 ? 170 LEU H CD2 1 
ATOM   1335 N N   . GLN A 1 178 ? -28.360 -4.568  40.130  1.00 28.18 ? 171 GLN H N   1 
ATOM   1336 C CA  . GLN A 1 178 ? -29.797 -4.813  40.074  1.00 28.89 ? 171 GLN H CA  1 
ATOM   1337 C C   . GLN A 1 178 ? -30.398 -4.020  38.923  1.00 30.15 ? 171 GLN H C   1 
ATOM   1338 O O   . GLN A 1 178 ? -29.726 -3.209  38.297  1.00 24.42 ? 171 GLN H O   1 
ATOM   1339 C CB  . GLN A 1 178 ? -30.440 -4.453  41.407  1.00 28.58 ? 171 GLN H CB  1 
ATOM   1340 C CG  . GLN A 1 178 ? -29.734 -5.117  42.572  1.00 26.48 ? 171 GLN H CG  1 
ATOM   1341 C CD  . GLN A 1 178 ? -30.087 -4.515  43.923  1.00 36.87 ? 171 GLN H CD  1 
ATOM   1342 O OE1 . GLN A 1 178 ? -30.648 -5.197  44.786  1.00 36.82 ? 171 GLN H OE1 1 
ATOM   1343 N NE2 . GLN A 1 178 ? -29.728 -3.255  44.128  1.00 30.94 ? 171 GLN H NE2 1 
ATOM   1344 N N   . SER A 1 179 ? -31.672 -4.271  38.611  1.00 31.27 ? 172 SER H N   1 
ATOM   1345 C CA  . SER A 1 179 ? -32.218 -3.566  37.458  1.00 35.44 ? 172 SER H CA  1 
ATOM   1346 C C   . SER A 1 179 ? -32.511 -2.112  37.780  1.00 35.41 ? 172 SER H C   1 
ATOM   1347 O O   . SER A 1 179 ? -32.659 -1.305  36.860  1.00 41.76 ? 172 SER H O   1 
ATOM   1348 C CB  . SER A 1 179 ? -33.472 -4.260  36.920  1.00 38.25 ? 172 SER H CB  1 
ATOM   1349 O OG  . SER A 1 179 ? -34.384 -4.530  37.959  1.00 43.36 ? 172 SER H OG  1 
ATOM   1350 N N   . SER A 1 180 ? -32.547 -1.759  39.064  1.00 32.46 ? 173 SER H N   1 
ATOM   1351 C CA  . SER A 1 180 ? -32.566 -0.357  39.462  1.00 31.76 ? 173 SER H CA  1 
ATOM   1352 C C   . SER A 1 180 ? -31.333 0.406   38.995  1.00 32.33 ? 173 SER H C   1 
ATOM   1353 O O   . SER A 1 180 ? -31.353 1.635   39.000  1.00 39.39 ? 173 SER H O   1 
ATOM   1354 C CB  . SER A 1 180 ? -32.665 -0.257  40.981  1.00 32.19 ? 173 SER H CB  1 
ATOM   1355 O OG  . SER A 1 180 ? -31.613 -0.994  41.597  1.00 27.92 ? 173 SER H OG  1 
ATOM   1356 N N   . GLY A 1 181 ? -30.256 -0.282  38.617  1.00 31.12 ? 174 GLY H N   1 
ATOM   1357 C CA  . GLY A 1 181 ? -28.971 0.356   38.392  1.00 31.18 ? 174 GLY H CA  1 
ATOM   1358 C C   . GLY A 1 181 ? -28.125 0.512   39.640  1.00 27.37 ? 174 GLY H C   1 
ATOM   1359 O O   . GLY A 1 181 ? -27.026 1.077   39.569  1.00 25.72 ? 174 GLY H O   1 
ATOM   1360 N N   . LEU A 1 182 ? -28.616 0.048   40.782  1.00 24.53 ? 175 LEU H N   1 
ATOM   1361 C CA  . LEU A 1 182 ? -27.893 0.097   42.039  1.00 27.06 ? 175 LEU H CA  1 
ATOM   1362 C C   . LEU A 1 182 ? -27.273 -1.269  42.314  1.00 26.45 ? 175 LEU H C   1 
ATOM   1363 O O   . LEU A 1 182 ? -27.770 -2.297  41.847  1.00 27.17 ? 175 LEU H O   1 
ATOM   1364 C CB  . LEU A 1 182 ? -28.832 0.494   43.185  1.00 29.04 ? 175 LEU H CB  1 
ATOM   1365 C CG  . LEU A 1 182 ? -29.653 1.774   42.982  1.00 28.75 ? 175 LEU H CG  1 
ATOM   1366 C CD1 . LEU A 1 182 ? -30.701 1.918   44.091  1.00 26.69 ? 175 LEU H CD1 1 
ATOM   1367 C CD2 . LEU A 1 182 ? -28.707 2.970   42.934  1.00 25.40 ? 175 LEU H CD2 1 
ATOM   1368 N N   . TYR A 1 183 ? -26.187 -1.267  43.073  1.00 21.98 ? 176 TYR H N   1 
ATOM   1369 C CA  . TYR A 1 183 ? -25.469 -2.489  43.410  1.00 24.14 ? 176 TYR H CA  1 
ATOM   1370 C C   . TYR A 1 183 ? -25.917 -3.027  44.767  1.00 28.14 ? 176 TYR H C   1 
ATOM   1371 O O   . TYR A 1 183 ? -26.390 -2.283  45.637  1.00 24.27 ? 176 TYR H O   1 
ATOM   1372 C CB  . TYR A 1 183 ? -23.962 -2.244  43.441  1.00 23.11 ? 176 TYR H CB  1 
ATOM   1373 C CG  . TYR A 1 183 ? -23.381 -1.861  42.083  1.00 25.48 ? 176 TYR H CG  1 
ATOM   1374 C CD1 . TYR A 1 183 ? -22.979 -2.838  41.161  1.00 25.30 ? 176 TYR H CD1 1 
ATOM   1375 C CD2 . TYR A 1 183 ? -23.245 -0.534  41.723  1.00 21.86 ? 176 TYR H CD2 1 
ATOM   1376 C CE1 . TYR A 1 183 ? -22.454 -2.477  39.900  1.00 22.35 ? 176 TYR H CE1 1 
ATOM   1377 C CE2 . TYR A 1 183 ? -22.712 -0.162  40.474  1.00 23.47 ? 176 TYR H CE2 1 
ATOM   1378 C CZ  . TYR A 1 183 ? -22.318 -1.133  39.578  1.00 26.40 ? 176 TYR H CZ  1 
ATOM   1379 O OH  . TYR A 1 183 ? -21.808 -0.735  38.356  1.00 21.48 ? 176 TYR H OH  1 
ATOM   1380 N N   . SER A 1 184 ? -25.748 -4.339  44.934  1.00 27.42 ? 177 SER H N   1 
ATOM   1381 C CA  . SER A 1 184 ? -26.003 -5.000  46.239  1.00 26.38 ? 177 SER H CA  1 
ATOM   1382 C C   . SER A 1 184 ? -24.898 -6.039  46.468  1.00 26.49 ? 177 SER H C   1 
ATOM   1383 O O   . SER A 1 184 ? -24.542 -6.724  45.511  1.00 24.95 ? 177 SER H O   1 
ATOM   1384 C CB  . SER A 1 184 ? -27.357 -5.600  46.349  1.00 27.56 ? 177 SER H CB  1 
ATOM   1385 O OG  . SER A 1 184 ? -27.615 -6.023  47.674  1.00 34.38 ? 177 SER H OG  1 
ATOM   1386 N N   . LEU A 1 185 ? -24.389 -6.127  47.692  1.00 26.07 ? 178 LEU H N   1 
ATOM   1387 C CA  . LEU A 1 185 ? -23.282 -7.046  48.045  1.00 25.69 ? 178 LEU H CA  1 
ATOM   1388 C C   . LEU A 1 185 ? -23.590 -7.676  49.406  1.00 29.84 ? 178 LEU H C   1 
ATOM   1389 O O   . LEU A 1 185 ? -24.261 -7.034  50.215  1.00 24.41 ? 178 LEU H O   1 
ATOM   1390 C CB  . LEU A 1 185 ? -21.999 -6.213  48.085  1.00 27.71 ? 178 LEU H CB  1 
ATOM   1391 C CG  . LEU A 1 185 ? -20.757 -6.778  48.768  1.00 31.56 ? 178 LEU H CG  1 
ATOM   1392 C CD1 . LEU A 1 185 ? -19.516 -6.197  48.115  1.00 31.38 ? 178 LEU H CD1 1 
ATOM   1393 C CD2 . LEU A 1 185 ? -20.745 -6.452  50.253  1.00 28.27 ? 178 LEU H CD2 1 
ATOM   1394 N N   . SER A 1 186 ? -23.096 -8.884  49.629  1.00 25.33 ? 179 SER H N   1 
ATOM   1395 C CA  . SER A 1 186 ? -23.261 -9.534  50.945  1.00 23.12 ? 179 SER H CA  1 
ATOM   1396 C C   . SER A 1 186 ? -21.890 -9.897  51.503  1.00 24.97 ? 179 SER H C   1 
ATOM   1397 O O   . SER A 1 186 ? -21.001 -10.206 50.713  1.00 26.22 ? 179 SER H O   1 
ATOM   1398 C CB  . SER A 1 186 ? -24.138 -10.752 50.853  1.00 24.98 ? 179 SER H CB  1 
ATOM   1399 O OG  . SER A 1 186 ? -23.460 -11.831 50.241  1.00 28.56 ? 179 SER H OG  1 
ATOM   1400 N N   . SER A 1 187 ? -21.727 -9.798  52.809  1.00 21.64 ? 180 SER H N   1 
ATOM   1401 C CA  . SER A 1 187 ? -20.520 -10.286 53.468  1.00 22.98 ? 180 SER H CA  1 
ATOM   1402 C C   . SER A 1 187 ? -20.988 -11.182 54.597  1.00 26.08 ? 180 SER H C   1 
ATOM   1403 O O   . SER A 1 187 ? -21.931 -10.829 55.317  1.00 22.97 ? 180 SER H O   1 
ATOM   1404 C CB  . SER A 1 187 ? -19.641 -9.144  54.006  1.00 26.76 ? 180 SER H CB  1 
ATOM   1405 O OG  . SER A 1 187 ? -18.453 -9.623  54.660  1.00 24.87 ? 180 SER H OG  1 
ATOM   1406 N N   . VAL A 1 188 ? -20.364 -12.352 54.722  1.00 23.41 ? 181 VAL H N   1 
ATOM   1407 C CA  . VAL A 1 188 ? -20.745 -13.334 55.724  1.00 22.37 ? 181 VAL H CA  1 
ATOM   1408 C C   . VAL A 1 188 ? -19.508 -13.805 56.458  1.00 28.58 ? 181 VAL H C   1 
ATOM   1409 O O   . VAL A 1 188 ? -18.370 -13.683 55.989  1.00 26.03 ? 181 VAL H O   1 
ATOM   1410 C CB  . VAL A 1 188 ? -21.478 -14.544 55.135  1.00 27.58 ? 181 VAL H CB  1 
ATOM   1411 C CG1 . VAL A 1 188 ? -22.728 -14.089 54.431  1.00 22.27 ? 181 VAL H CG1 1 
ATOM   1412 C CG2 . VAL A 1 188 ? -20.562 -15.316 54.198  1.00 26.43 ? 181 VAL H CG2 1 
ATOM   1413 N N   . VAL A 1 189 ? -19.754 -14.347 57.639  1.00 26.97 ? 182 VAL H N   1 
ATOM   1414 C CA  . VAL A 1 189 ? -18.690 -14.894 58.453  1.00 24.16 ? 182 VAL H CA  1 
ATOM   1415 C C   . VAL A 1 189 ? -19.286 -16.052 59.241  1.00 24.60 ? 182 VAL H C   1 
ATOM   1416 O O   . VAL A 1 189 ? -20.445 -15.997 59.661  1.00 23.90 ? 182 VAL H O   1 
ATOM   1417 C CB  . VAL A 1 189 ? -18.063 -13.790 59.339  1.00 22.28 ? 182 VAL H CB  1 
ATOM   1418 C CG1 . VAL A 1 189 ? -19.139 -13.078 60.166  1.00 23.01 ? 182 VAL H CG1 1 
ATOM   1419 C CG2 . VAL A 1 189 ? -16.950 -14.354 60.211  1.00 26.12 ? 182 VAL H CG2 1 
ATOM   1420 N N   . THR A 1 190 ? -18.524 -17.139 59.354  1.00 28.61 ? 183 THR H N   1 
ATOM   1421 C CA  . THR A 1 190 ? -18.882 -18.255 60.220  1.00 25.84 ? 183 THR H CA  1 
ATOM   1422 C C   . THR A 1 190 ? -18.030 -18.183 61.477  1.00 28.21 ? 183 THR H C   1 
ATOM   1423 O O   . THR A 1 190 ? -16.819 -17.963 61.398  1.00 27.81 ? 183 THR H O   1 
ATOM   1424 C CB  . THR A 1 190 ? -18.678 -19.588 59.511  1.00 25.65 ? 183 THR H CB  1 
ATOM   1425 O OG1 . THR A 1 190 ? -17.361 -19.623 58.972  1.00 37.27 ? 183 THR H OG1 1 
ATOM   1426 C CG2 . THR A 1 190 ? -19.674 -19.745 58.387  1.00 24.48 ? 183 THR H CG2 1 
ATOM   1427 N N   . VAL A 1 191 ? -18.674 -18.336 62.629  1.00 27.50 ? 184 VAL H N   1 
ATOM   1428 C CA  . VAL A 1 191 ? -18.047 -18.122 63.930  1.00 28.97 ? 184 VAL H CA  1 
ATOM   1429 C C   . VAL A 1 191 ? -18.453 -19.277 64.839  1.00 30.70 ? 184 VAL H C   1 
ATOM   1430 O O   . VAL A 1 191 ? -19.368 -20.036 64.490  1.00 27.28 ? 184 VAL H O   1 
ATOM   1431 C CB  . VAL A 1 191 ? -18.480 -16.783 64.545  1.00 30.08 ? 184 VAL H CB  1 
ATOM   1432 C CG1 . VAL A 1 191 ? -18.331 -15.644 63.546  1.00 31.71 ? 184 VAL H CG1 1 
ATOM   1433 C CG2 . VAL A 1 191 ? -19.889 -16.893 65.035  1.00 26.56 ? 184 VAL H CG2 1 
ATOM   1434 N N   . PRO A 1 192 ? -17.829 -19.444 66.005  1.00 31.63 ? 185 PRO H N   1 
ATOM   1435 C CA  . PRO A 1 192 ? -18.324 -20.451 66.953  1.00 30.37 ? 185 PRO H CA  1 
ATOM   1436 C C   . PRO A 1 192 ? -19.757 -20.159 67.371  1.00 28.99 ? 185 PRO H C   1 
ATOM   1437 O O   . PRO A 1 192 ? -20.086 -19.049 67.802  1.00 28.14 ? 185 PRO H O   1 
ATOM   1438 C CB  . PRO A 1 192 ? -17.351 -20.331 68.135  1.00 31.56 ? 185 PRO H CB  1 
ATOM   1439 C CG  . PRO A 1 192 ? -16.091 -19.772 67.538  1.00 29.39 ? 185 PRO H CG  1 
ATOM   1440 C CD  . PRO A 1 192 ? -16.564 -18.830 66.457  1.00 29.10 ? 185 PRO H CD  1 
ATOM   1441 N N   . SER A 1 193 ? -20.611 -21.182 67.285  1.00 27.61 ? 186 SER H N   1 
ATOM   1442 C CA  . SER A 1 193 ? -21.998 -20.998 67.705  1.00 31.30 ? 186 SER H CA  1 
ATOM   1443 C C   . SER A 1 193 ? -22.102 -20.633 69.193  1.00 34.05 ? 186 SER H C   1 
ATOM   1444 O O   . SER A 1 193 ? -23.035 -19.922 69.594  1.00 34.89 ? 186 SER H O   1 
ATOM   1445 C CB  . SER A 1 193 ? -22.820 -22.254 67.378  1.00 31.16 ? 186 SER H CB  1 
ATOM   1446 O OG  . SER A 1 193 ? -22.380 -23.388 68.118  1.00 38.61 ? 186 SER H OG  1 
ATOM   1447 N N   . SER A 1 194 ? -21.146 -21.071 70.021  1.00 29.91 ? 187 SER H N   1 
ATOM   1448 C CA  . SER A 1 194 ? -21.214 -20.736 71.440  1.00 35.99 ? 187 SER H CA  1 
ATOM   1449 C C   . SER A 1 194 ? -20.894 -19.267 71.706  1.00 35.97 ? 187 SER H C   1 
ATOM   1450 O O   . SER A 1 194 ? -21.260 -18.751 72.765  1.00 36.94 ? 187 SER H O   1 
ATOM   1451 C CB  . SER A 1 194 ? -20.277 -21.643 72.255  1.00 30.95 ? 187 SER H CB  1 
ATOM   1452 O OG  . SER A 1 194 ? -18.935 -21.520 71.832  1.00 35.11 ? 187 SER H OG  1 
ATOM   1453 N N   . SER A 1 195 ? -20.250 -18.577 70.761  1.00 31.63 ? 188 SER H N   1 
ATOM   1454 C CA  . SER A 1 195 ? -19.953 -17.155 70.903  1.00 34.43 ? 188 SER H CA  1 
ATOM   1455 C C   . SER A 1 195 ? -21.160 -16.245 70.677  1.00 34.70 ? 188 SER H C   1 
ATOM   1456 O O   . SER A 1 195 ? -21.052 -15.042 70.922  1.00 38.34 ? 188 SER H O   1 
ATOM   1457 C CB  . SER A 1 195 ? -18.852 -16.759 69.918  1.00 31.53 ? 188 SER H CB  1 
ATOM   1458 O OG  . SER A 1 195 ? -19.399 -16.670 68.606  1.00 31.21 ? 188 SER H OG  1 
ATOM   1459 N N   . LEU A 1 196 ? -22.294 -16.765 70.212  1.00 33.74 ? 189 LEU H N   1 
ATOM   1460 C CA  . LEU A 1 196 ? -23.350 -15.878 69.722  1.00 33.87 ? 189 LEU H CA  1 
ATOM   1461 C C   . LEU A 1 196 ? -23.927 -14.991 70.824  1.00 40.59 ? 189 LEU H C   1 
ATOM   1462 O O   . LEU A 1 196 ? -24.148 -13.794 70.610  1.00 41.82 ? 189 LEU H O   1 
ATOM   1463 C CB  . LEU A 1 196 ? -24.449 -16.689 69.052  1.00 31.72 ? 189 LEU H CB  1 
ATOM   1464 C CG  . LEU A 1 196 ? -23.980 -17.247 67.713  1.00 32.92 ? 189 LEU H CG  1 
ATOM   1465 C CD1 . LEU A 1 196 ? -25.120 -17.954 67.029  1.00 26.44 ? 189 LEU H CD1 1 
ATOM   1466 C CD2 . LEU A 1 196 ? -23.402 -16.108 66.844  1.00 27.52 ? 189 LEU H CD2 1 
ATOM   1467 N N   . GLY A 1 197 ? -24.182 -15.538 72.006  1.00 44.02 ? 190 GLY H N   1 
ATOM   1468 C CA  . GLY A 1 197 ? -24.698 -14.634 73.025  1.00 50.47 ? 190 GLY H CA  1 
ATOM   1469 C C   . GLY A 1 197 ? -23.668 -13.671 73.597  1.00 49.31 ? 190 GLY H C   1 
ATOM   1470 O O   . GLY A 1 197 ? -24.044 -12.713 74.279  1.00 45.86 ? 190 GLY H O   1 
ATOM   1471 N N   . THR A 1 198 ? -22.391 -13.884 73.316  1.00 43.36 ? 191 THR H N   1 
ATOM   1472 C CA  . THR A 1 198 ? -21.353 -13.273 74.125  1.00 42.14 ? 191 THR H CA  1 
ATOM   1473 C C   . THR A 1 198 ? -20.377 -12.398 73.347  1.00 46.95 ? 191 THR H C   1 
ATOM   1474 O O   . THR A 1 198 ? -19.869 -11.431 73.916  1.00 46.61 ? 191 THR H O   1 
ATOM   1475 C CB  . THR A 1 198 ? -20.589 -14.373 74.890  1.00 42.29 ? 191 THR H CB  1 
ATOM   1476 O OG1 . THR A 1 198 ? -20.033 -13.823 76.085  1.00 51.47 ? 191 THR H OG1 1 
ATOM   1477 C CG2 . THR A 1 198 ? -19.466 -14.997 74.045  1.00 41.71 ? 191 THR H CG2 1 
ATOM   1478 N N   . GLN A 1 199 ? -20.113 -12.689 72.071  1.00 41.82 ? 192 GLN H N   1 
ATOM   1479 C CA  . GLN A 1 199 ? -19.162 -11.932 71.264  1.00 38.79 ? 192 GLN H CA  1 
ATOM   1480 C C   . GLN A 1 199 ? -19.921 -10.962 70.377  1.00 40.62 ? 192 GLN H C   1 
ATOM   1481 O O   . GLN A 1 199 ? -20.880 -11.355 69.700  1.00 37.09 ? 192 GLN H O   1 
ATOM   1482 C CB  . GLN A 1 199 ? -18.304 -12.863 70.402  1.00 39.60 ? 192 GLN H CB  1 
ATOM   1483 C CG  . GLN A 1 199 ? -17.416 -12.147 69.374  1.00 36.86 ? 192 GLN H CG  1 
ATOM   1484 C CD  . GLN A 1 199 ? -16.411 -11.196 69.996  1.00 39.32 ? 192 GLN H CD  1 
ATOM   1485 O OE1 . GLN A 1 199 ? -15.585 -11.593 70.824  1.00 41.89 ? 192 GLN H OE1 1 
ATOM   1486 N NE2 . GLN A 1 199 ? -16.466 -9.925  69.587  1.00 36.23 ? 192 GLN H NE2 1 
ATOM   1487 N N   . THR A 1 200 ? -19.504 -9.698  70.387  1.00 38.46 ? 193 THR H N   1 
ATOM   1488 C CA  . THR A 1 200 ? -20.131 -8.715  69.518  1.00 38.35 ? 193 THR H CA  1 
ATOM   1489 C C   . THR A 1 200 ? -19.568 -8.844  68.108  1.00 30.07 ? 193 THR H C   1 
ATOM   1490 O O   . THR A 1 200 ? -18.357 -8.971  67.925  1.00 31.89 ? 193 THR H O   1 
ATOM   1491 C CB  . THR A 1 200 ? -19.926 -7.301  70.057  1.00 36.88 ? 193 THR H CB  1 
ATOM   1492 O OG1 . THR A 1 200 ? -20.823 -7.088  71.153  1.00 44.27 ? 193 THR H OG1 1 
ATOM   1493 C CG2 . THR A 1 200 ? -20.244 -6.273  68.975  1.00 35.95 ? 193 THR H CG2 1 
ATOM   1494 N N   . TYR A 1 201 ? -20.455 -8.844  67.118  1.00 31.44 ? 194 TYR H N   1 
ATOM   1495 C CA  . TYR A 1 201 ? -20.068 -8.924  65.716  1.00 35.00 ? 194 TYR H CA  1 
ATOM   1496 C C   . TYR A 1 201 ? -20.596 -7.686  64.993  1.00 31.44 ? 194 TYR H C   1 
ATOM   1497 O O   . TYR A 1 201 ? -21.811 -7.448  64.957  1.00 27.56 ? 194 TYR H O   1 
ATOM   1498 C CB  . TYR A 1 201 ? -20.582 -10.223 65.080  1.00 26.24 ? 194 TYR H CB  1 
ATOM   1499 C CG  . TYR A 1 201 ? -19.906 -11.457 65.666  1.00 28.21 ? 194 TYR H CG  1 
ATOM   1500 C CD1 . TYR A 1 201 ? -18.558 -11.704 65.430  1.00 27.17 ? 194 TYR H CD1 1 
ATOM   1501 C CD2 . TYR A 1 201 ? -20.608 -12.358 66.456  1.00 32.54 ? 194 TYR H CD2 1 
ATOM   1502 C CE1 . TYR A 1 201 ? -17.923 -12.800 65.961  1.00 32.27 ? 194 TYR H CE1 1 
ATOM   1503 C CE2 . TYR A 1 201 ? -19.969 -13.482 66.994  1.00 32.65 ? 194 TYR H CE2 1 
ATOM   1504 C CZ  . TYR A 1 201 ? -18.628 -13.683 66.740  1.00 33.46 ? 194 TYR H CZ  1 
ATOM   1505 O OH  . TYR A 1 201 ? -17.972 -14.762 67.267  1.00 29.91 ? 194 TYR H OH  1 
ATOM   1506 N N   . ILE A 1 202 ? -19.676 -6.900  64.437  1.00 24.08 ? 195 ILE H N   1 
ATOM   1507 C CA  . ILE A 1 202 ? -19.997 -5.671  63.716  1.00 28.38 ? 195 ILE H CA  1 
ATOM   1508 C C   . ILE A 1 202 ? -19.336 -5.724  62.342  1.00 25.59 ? 195 ILE H C   1 
ATOM   1509 O O   . ILE A 1 202 ? -18.133 -5.982  62.236  1.00 28.79 ? 195 ILE H O   1 
ATOM   1510 C CB  . ILE A 1 202 ? -19.521 -4.425  64.486  1.00 30.05 ? 195 ILE H CB  1 
ATOM   1511 C CG1 . ILE A 1 202 ? -20.201 -4.346  65.849  1.00 35.06 ? 195 ILE H CG1 1 
ATOM   1512 C CG2 . ILE A 1 202 ? -19.805 -3.151  63.691  1.00 30.11 ? 195 ILE H CG2 1 
ATOM   1513 C CD1 . ILE A 1 202 ? -19.450 -3.447  66.833  1.00 29.37 ? 195 ILE H CD1 1 
ATOM   1514 N N   . CYS A 1 203 ? -20.107 -5.476  61.293  1.00 31.06 ? 196 CYS H N   1 
ATOM   1515 C CA  . CYS A 1 203 ? -19.523 -5.320  59.968  1.00 26.57 ? 196 CYS H CA  1 
ATOM   1516 C C   . CYS A 1 203 ? -19.306 -3.839  59.697  1.00 29.33 ? 196 CYS H C   1 
ATOM   1517 O O   . CYS A 1 203 ? -20.164 -3.003  59.996  1.00 27.92 ? 196 CYS H O   1 
ATOM   1518 C CB  . CYS A 1 203 ? -20.406 -5.929  58.879  1.00 25.78 ? 196 CYS H CB  1 
ATOM   1519 S SG  . CYS A 1 203 ? -21.936 -5.056  58.506  1.00 32.02 ? 196 CYS H SG  1 
ATOM   1520 N N   . ASN A 1 204 ? -18.144 -3.520  59.163  1.00 33.78 ? 197 ASN H N   1 
ATOM   1521 C CA  . ASN A 1 204 ? -17.771 -2.147  58.853  1.00 28.95 ? 197 ASN H CA  1 
ATOM   1522 C C   . ASN A 1 204 ? -17.788 -2.018  57.337  1.00 25.70 ? 197 ASN H C   1 
ATOM   1523 O O   . ASN A 1 204 ? -16.925 -2.576  56.655  1.00 28.78 ? 197 ASN H O   1 
ATOM   1524 C CB  . ASN A 1 204 ? -16.398 -1.824  59.422  1.00 27.12 ? 197 ASN H CB  1 
ATOM   1525 C CG  . ASN A 1 204 ? -16.147 -2.506  60.755  1.00 32.08 ? 197 ASN H CG  1 
ATOM   1526 O OD1 . ASN A 1 204 ? -15.304 -3.406  60.859  1.00 32.52 ? 197 ASN H OD1 1 
ATOM   1527 N ND2 . ASN A 1 204 ? -16.850 -2.062  61.786  1.00 27.28 ? 197 ASN H ND2 1 
ATOM   1528 N N   . VAL A 1 205 ? -18.782 -1.318  56.809  1.00 26.63 ? 198 VAL H N   1 
ATOM   1529 C CA  . VAL A 1 205 ? -18.938 -1.139  55.370  1.00 25.64 ? 198 VAL H CA  1 
ATOM   1530 C C   . VAL A 1 205 ? -18.405 0.243   55.021  1.00 32.15 ? 198 VAL H C   1 
ATOM   1531 O O   . VAL A 1 205 ? -18.860 1.253   55.580  1.00 28.41 ? 198 VAL H O   1 
ATOM   1532 C CB  . VAL A 1 205 ? -20.407 -1.287  54.952  1.00 26.31 ? 198 VAL H CB  1 
ATOM   1533 C CG1 . VAL A 1 205 ? -20.559 -1.229  53.439  1.00 26.09 ? 198 VAL H CG1 1 
ATOM   1534 C CG2 . VAL A 1 205 ? -20.987 -2.576  55.545  1.00 27.33 ? 198 VAL H CG2 1 
ATOM   1535 N N   . ASN A 1 206 ? -17.432 0.308   54.116  1.00 24.41 ? 199 ASN H N   1 
ATOM   1536 C CA  . ASN A 1 206 ? -16.932 1.593   53.647  1.00 28.14 ? 199 ASN H CA  1 
ATOM   1537 C C   . ASN A 1 206 ? -17.339 1.784   52.195  1.00 29.74 ? 199 ASN H C   1 
ATOM   1538 O O   . ASN A 1 206 ? -17.018 0.947   51.342  1.00 29.20 ? 199 ASN H O   1 
ATOM   1539 C CB  . ASN A 1 206 ? -15.415 1.704   53.807  1.00 31.24 ? 199 ASN H CB  1 
ATOM   1540 C CG  . ASN A 1 206 ? -14.922 3.144   53.639  1.00 34.02 ? 199 ASN H CG  1 
ATOM   1541 O OD1 . ASN A 1 206 ? -15.723 4.093   53.520  1.00 34.95 ? 199 ASN H OD1 1 
ATOM   1542 N ND2 . ASN A 1 206 ? -13.613 3.315   53.644  1.00 38.87 ? 199 ASN H ND2 1 
ATOM   1543 N N   . HIS A 1 207 ? -18.073 2.861   51.919  1.00 28.12 ? 200 HIS H N   1 
ATOM   1544 C CA  . HIS A 1 207 ? -18.428 3.234   50.549  1.00 23.87 ? 200 HIS H CA  1 
ATOM   1545 C C   . HIS A 1 207 ? -17.799 4.586   50.251  1.00 26.81 ? 200 HIS H C   1 
ATOM   1546 O O   . HIS A 1 207 ? -18.464 5.612   50.323  1.00 26.01 ? 200 HIS H O   1 
ATOM   1547 C CB  . HIS A 1 207 ? -19.875 3.280   50.378  1.00 24.46 ? 200 HIS H CB  1 
ATOM   1548 C CG  . HIS A 1 207 ? -20.309 3.510   48.966  1.00 25.52 ? 200 HIS H CG  1 
ATOM   1549 N ND1 . HIS A 1 207 ? -21.253 4.456   48.629  1.00 21.69 ? 200 HIS H ND1 1 
ATOM   1550 C CD2 . HIS A 1 207 ? -19.930 2.918   47.804  1.00 23.65 ? 200 HIS H CD2 1 
ATOM   1551 C CE1 . HIS A 1 207 ? -21.449 4.427   47.321  1.00 25.60 ? 200 HIS H CE1 1 
ATOM   1552 N NE2 . HIS A 1 207 ? -20.665 3.498   46.800  1.00 25.08 ? 200 HIS H NE2 1 
ATOM   1553 N N   . LYS A 1 208 ? -16.524 4.564   49.870  1.00 28.87 ? 201 LYS H N   1 
ATOM   1554 C CA  . LYS A 1 208 ? -15.806 5.793   49.538  1.00 30.76 ? 201 LYS H CA  1 
ATOM   1555 C C   . LYS A 1 208 ? -16.458 6.627   48.439  1.00 28.23 ? 201 LYS H C   1 
ATOM   1556 O O   . LYS A 1 208 ? -16.408 7.863   48.542  1.00 30.42 ? 201 LYS H O   1 
ATOM   1557 C CB  . LYS A 1 208 ? -14.357 5.448   49.168  1.00 27.80 ? 201 LYS H CB  1 
ATOM   1558 C CG  . LYS A 1 208 ? -13.565 4.809   50.311  1.00 39.71 ? 201 LYS H CG  1 
ATOM   1559 C CD  . LYS A 1 208 ? -12.080 5.220   50.306  1.00 43.10 ? 201 LYS H CD  1 
ATOM   1560 C CE  . LYS A 1 208 ? -11.220 4.254   51.129  1.00 45.38 ? 201 LYS H CE  1 
ATOM   1561 N NZ  . LYS A 1 208 ? -10.522 3.254   50.251  1.00 47.90 ? 201 LYS H NZ  1 
ATOM   1562 N N   . PRO A 1 209 ? -17.055 6.054   47.387  1.00 28.00 ? 202 PRO H N   1 
ATOM   1563 C CA  . PRO A 1 209 ? -17.722 6.899   46.378  1.00 26.11 ? 202 PRO H CA  1 
ATOM   1564 C C   . PRO A 1 209 ? -18.761 7.861   46.931  1.00 28.49 ? 202 PRO H C   1 
ATOM   1565 O O   . PRO A 1 209 ? -18.937 8.936   46.349  1.00 26.37 ? 202 PRO H O   1 
ATOM   1566 C CB  . PRO A 1 209 ? -18.365 5.863   45.440  1.00 23.56 ? 202 PRO H CB  1 
ATOM   1567 C CG  . PRO A 1 209 ? -17.371 4.711   45.481  1.00 27.32 ? 202 PRO H CG  1 
ATOM   1568 C CD  . PRO A 1 209 ? -16.992 4.643   46.948  1.00 27.33 ? 202 PRO H CD  1 
ATOM   1569 N N   . SER A 1 210 ? -19.488 7.513   47.995  1.00 27.62 ? 203 SER H N   1 
ATOM   1570 C CA  . SER A 1 210 ? -20.434 8.445   48.602  1.00 27.40 ? 203 SER H CA  1 
ATOM   1571 C C   . SER A 1 210 ? -19.935 8.985   49.940  1.00 26.00 ? 203 SER H C   1 
ATOM   1572 O O   . SER A 1 210 ? -20.705 9.620   50.659  1.00 29.28 ? 203 SER H O   1 
ATOM   1573 C CB  . SER A 1 210 ? -21.820 7.806   48.778  1.00 25.68 ? 203 SER H CB  1 
ATOM   1574 O OG  . SER A 1 210 ? -21.889 6.871   49.857  1.00 23.50 ? 203 SER H OG  1 
ATOM   1575 N N   . ASN A 1 211 ? -18.673 8.736   50.288  1.00 28.45 ? 204 ASN H N   1 
ATOM   1576 C CA  . ASN A 1 211 ? -18.101 9.149   51.575  1.00 30.32 ? 204 ASN H CA  1 
ATOM   1577 C C   . ASN A 1 211 ? -18.977 8.700   52.746  1.00 34.06 ? 204 ASN H C   1 
ATOM   1578 O O   . ASN A 1 211 ? -19.175 9.430   53.726  1.00 30.30 ? 204 ASN H O   1 
ATOM   1579 C CB  . ASN A 1 211 ? -17.879 10.658  51.625  1.00 31.00 ? 204 ASN H CB  1 
ATOM   1580 C CG  . ASN A 1 211 ? -16.784 11.115  50.688  1.00 37.37 ? 204 ASN H CG  1 
ATOM   1581 O OD1 . ASN A 1 211 ? -17.047 11.492  49.549  1.00 43.07 ? 204 ASN H OD1 1 
ATOM   1582 N ND2 . ASN A 1 211 ? -15.553 11.086  51.163  1.00 37.58 ? 204 ASN H ND2 1 
ATOM   1583 N N   . THR A 1 212 ? -19.508 7.484   52.644  1.00 30.52 ? 205 THR H N   1 
ATOM   1584 C CA  . THR A 1 212 ? -20.309 6.894   53.703  1.00 27.17 ? 205 THR H CA  1 
ATOM   1585 C C   . THR A 1 212 ? -19.580 5.688   54.269  1.00 32.21 ? 205 THR H C   1 
ATOM   1586 O O   . THR A 1 212 ? -19.078 4.846   53.513  1.00 28.90 ? 205 THR H O   1 
ATOM   1587 C CB  . THR A 1 212 ? -21.681 6.473   53.198  1.00 26.15 ? 205 THR H CB  1 
ATOM   1588 O OG1 . THR A 1 212 ? -22.258 7.536   52.438  1.00 28.00 ? 205 THR H OG1 1 
ATOM   1589 C CG2 . THR A 1 212 ? -22.588 6.107   54.387  1.00 28.79 ? 205 THR H CG2 1 
ATOM   1590 N N   . LYS A 1 213 ? -19.513 5.620   55.592  1.00 27.38 ? 206 LYS H N   1 
ATOM   1591 C CA  . LYS A 1 213 ? -19.049 4.440   56.296  1.00 28.29 ? 206 LYS H CA  1 
ATOM   1592 C C   . LYS A 1 213 ? -20.138 4.058   57.290  1.00 32.55 ? 206 LYS H C   1 
ATOM   1593 O O   . LYS A 1 213 ? -20.613 4.911   58.054  1.00 31.69 ? 206 LYS H O   1 
ATOM   1594 C CB  . LYS A 1 213 ? -17.717 4.685   57.010  1.00 28.54 ? 206 LYS H CB  1 
ATOM   1595 C CG  . LYS A 1 213 ? -17.008 3.377   57.346  1.00 38.99 ? 206 LYS H CG  1 
ATOM   1596 C CD  . LYS A 1 213 ? -16.089 3.471   58.553  1.00 46.01 ? 206 LYS H CD  1 
ATOM   1597 C CE  . LYS A 1 213 ? -15.547 2.089   58.931  1.00 46.24 ? 206 LYS H CE  1 
ATOM   1598 N NZ  . LYS A 1 213 ? -15.185 1.967   60.379  1.00 49.13 ? 206 LYS H NZ  1 
ATOM   1599 N N   . VAL A 1 214 ? -20.561 2.793   57.247  1.00 29.76 ? 207 VAL H N   1 
ATOM   1600 C CA  . VAL A 1 214 ? -21.640 2.265   58.077  1.00 29.44 ? 207 VAL H CA  1 
ATOM   1601 C C   . VAL A 1 214 ? -21.076 1.118   58.911  1.00 33.57 ? 207 VAL H C   1 
ATOM   1602 O O   . VAL A 1 214 ? -20.452 0.191   58.370  1.00 31.05 ? 207 VAL H O   1 
ATOM   1603 C CB  . VAL A 1 214 ? -22.834 1.783   57.227  1.00 26.75 ? 207 VAL H CB  1 
ATOM   1604 C CG1 . VAL A 1 214 ? -23.949 1.242   58.110  1.00 28.36 ? 207 VAL H CG1 1 
ATOM   1605 C CG2 . VAL A 1 214 ? -23.351 2.889   56.372  1.00 25.73 ? 207 VAL H CG2 1 
ATOM   1606 N N   . ASP A 1 215 ? -21.265 1.200   60.222  1.00 28.97 ? 208 ASP H N   1 
ATOM   1607 C CA  . ASP A 1 215 ? -21.003 0.092   61.127  1.00 32.72 ? 208 ASP H CA  1 
ATOM   1608 C C   . ASP A 1 215 ? -22.335 -0.483  61.588  1.00 32.19 ? 208 ASP H C   1 
ATOM   1609 O O   . ASP A 1 215 ? -23.201 0.257   62.065  1.00 35.18 ? 208 ASP H O   1 
ATOM   1610 C CB  . ASP A 1 215 ? -20.165 0.548   62.312  1.00 27.36 ? 208 ASP H CB  1 
ATOM   1611 C CG  . ASP A 1 215 ? -18.847 1.128   61.878  1.00 35.88 ? 208 ASP H CG  1 
ATOM   1612 O OD1 . ASP A 1 215 ? -18.067 0.408   61.219  1.00 34.37 ? 208 ASP H OD1 1 
ATOM   1613 O OD2 . ASP A 1 215 ? -18.602 2.327   62.145  1.00 44.17 ? 208 ASP H OD2 1 
ATOM   1614 N N   . LYS A 1 216 ? -22.498 -1.794  61.432  1.00 28.34 ? 209 LYS H N   1 
ATOM   1615 C CA  . LYS A 1 216 ? -23.740 -2.479  61.756  1.00 32.09 ? 209 LYS H CA  1 
ATOM   1616 C C   . LYS A 1 216 ? -23.439 -3.603  62.733  1.00 32.95 ? 209 LYS H C   1 
ATOM   1617 O O   . LYS A 1 216 ? -22.640 -4.497  62.422  1.00 28.18 ? 209 LYS H O   1 
ATOM   1618 C CB  . LYS A 1 216 ? -24.399 -3.036  60.496  1.00 31.97 ? 209 LYS H CB  1 
ATOM   1619 C CG  . LYS A 1 216 ? -25.832 -3.484  60.691  1.00 30.00 ? 209 LYS H CG  1 
ATOM   1620 C CD  . LYS A 1 216 ? -26.641 -2.376  61.351  1.00 35.43 ? 209 LYS H CD  1 
ATOM   1621 C CE  . LYS A 1 216 ? -28.142 -2.540  61.166  1.00 37.98 ? 209 LYS H CE  1 
ATOM   1622 N NZ  . LYS A 1 216 ? -28.707 -1.523  60.188  1.00 37.88 ? 209 LYS H NZ  1 
ATOM   1623 N N   . ARG A 1 217 ? -24.068 -3.549  63.908  1.00 31.68 ? 210 ARG H N   1 
ATOM   1624 C CA  . ARG A 1 217 ? -24.013 -4.650  64.856  1.00 28.85 ? 210 ARG H CA  1 
ATOM   1625 C C   . ARG A 1 217 ? -25.037 -5.705  64.461  1.00 33.64 ? 210 ARG H C   1 
ATOM   1626 O O   . ARG A 1 217 ? -26.223 -5.397  64.298  1.00 29.21 ? 210 ARG H O   1 
ATOM   1627 C CB  . ARG A 1 217 ? -24.289 -4.163  66.283  1.00 38.63 ? 210 ARG H CB  1 
ATOM   1628 C CG  . ARG A 1 217 ? -24.086 -5.252  67.353  1.00 42.39 ? 210 ARG H CG  1 
ATOM   1629 C CD  . ARG A 1 217 ? -24.514 -4.802  68.755  1.00 49.65 ? 210 ARG H CD  1 
ATOM   1630 N NE  . ARG A 1 217 ? -23.986 -5.681  69.797  1.00 55.85 ? 210 ARG H NE  1 
ATOM   1631 C CZ  . ARG A 1 217 ? -24.111 -5.468  71.103  1.00 59.33 ? 210 ARG H CZ  1 
ATOM   1632 N NH1 . ARG A 1 217 ? -24.762 -4.412  71.577  1.00 57.93 ? 210 ARG H NH1 1 
ATOM   1633 N NH2 . ARG A 1 217 ? -23.568 -6.333  71.957  1.00 60.97 ? 210 ARG H NH2 1 
ATOM   1634 N N   . VAL A 1 218 ? -24.580 -6.949  64.311  1.00 32.53 ? 211 VAL H N   1 
ATOM   1635 C CA  . VAL A 1 218 ? -25.447 -8.055  63.907  1.00 29.81 ? 211 VAL H CA  1 
ATOM   1636 C C   . VAL A 1 218 ? -25.741 -8.892  65.150  1.00 30.61 ? 211 VAL H C   1 
ATOM   1637 O O   . VAL A 1 218 ? -24.864 -9.597  65.657  1.00 30.55 ? 211 VAL H O   1 
ATOM   1638 C CB  . VAL A 1 218 ? -24.809 -8.903  62.796  1.00 32.78 ? 211 VAL H CB  1 
ATOM   1639 C CG1 . VAL A 1 218 ? -25.807 -9.952  62.304  1.00 27.52 ? 211 VAL H CG1 1 
ATOM   1640 C CG2 . VAL A 1 218 ? -24.350 -8.015  61.623  1.00 29.84 ? 211 VAL H CG2 1 
ATOM   1641 N N   . GLU A 1 219 ? -26.975 -8.812  65.649  1.00 33.25 ? 212 GLU H N   1 
ATOM   1642 C CA  . GLU A 1 219 ? -27.371 -9.510  66.861  1.00 36.00 ? 212 GLU H CA  1 
ATOM   1643 C C   . GLU A 1 219 ? -28.160 -10.770 66.519  1.00 32.34 ? 212 GLU H C   1 
ATOM   1644 O O   . GLU A 1 219 ? -28.870 -10.812 65.513  1.00 33.60 ? 212 GLU H O   1 
ATOM   1645 C CB  . GLU A 1 219 ? -28.215 -8.591  67.750  1.00 36.39 ? 212 GLU H CB  1 
ATOM   1646 C CG  . GLU A 1 219 ? -27.473 -7.313  68.123  1.00 34.35 ? 212 GLU H CG  1 
ATOM   1647 C CD  . GLU A 1 219 ? -28.155 -6.523  69.212  1.00 42.68 ? 212 GLU H CD  1 
ATOM   1648 O OE1 . GLU A 1 219 ? -29.352 -6.210  69.055  1.00 47.30 ? 212 GLU H OE1 1 
ATOM   1649 O OE2 . GLU A 1 219 ? -27.496 -6.211  70.227  1.00 45.57 ? 212 GLU H OE2 1 
ATOM   1650 N N   . PRO A 1 220 ? -28.047 -11.818 67.326  1.00 33.86 ? 213 PRO H N   1 
ATOM   1651 C CA  . PRO A 1 220 ? -28.753 -13.065 67.015  1.00 33.98 ? 213 PRO H CA  1 
ATOM   1652 C C   . PRO A 1 220 ? -30.257 -12.894 67.115  1.00 38.25 ? 213 PRO H C   1 
ATOM   1653 O O   . PRO A 1 220 ? -30.765 -12.009 67.807  1.00 45.23 ? 213 PRO H O   1 
ATOM   1654 C CB  . PRO A 1 220 ? -28.236 -14.043 68.077  1.00 37.11 ? 213 PRO H CB  1 
ATOM   1655 C CG  . PRO A 1 220 ? -26.937 -13.461 68.547  1.00 37.79 ? 213 PRO H CG  1 
ATOM   1656 C CD  . PRO A 1 220 ? -27.132 -11.967 68.471  1.00 32.69 ? 213 PRO H CD  1 
ATOM   1657 N N   . LYS A 1 221 ? -30.974 -13.756 66.402  1.00 39.02 ? 214 LYS H N   1 
ATOM   1658 C CA  . LYS A 1 221 ? -32.435 -13.759 66.479  1.00 44.55 ? 214 LYS H CA  1 
ATOM   1659 C C   . LYS A 1 221 ? -32.901 -14.527 67.714  1.00 44.84 ? 214 LYS H C   1 
ATOM   1660 O O   . LYS A 1 221 ? -32.189 -15.406 68.205  1.00 50.13 ? 214 LYS H O   1 
ATOM   1661 C CB  . LYS A 1 221 ? -33.056 -14.372 65.221  1.00 46.24 ? 214 LYS H CB  1 
ATOM   1662 C CG  . LYS A 1 221 ? -32.971 -13.491 63.985  1.00 47.60 ? 214 LYS H CG  1 
ATOM   1663 C CD  . LYS A 1 221 ? -34.309 -12.838 63.603  1.00 49.71 ? 214 LYS H CD  1 
ATOM   1664 C CE  . LYS A 1 221 ? -35.110 -13.744 62.670  1.00 61.45 ? 214 LYS H CE  1 
ATOM   1665 N NZ  . LYS A 1 221 ? -35.895 -12.967 61.666  1.00 59.08 ? 214 LYS H NZ  1 
ATOM   1666 N N   . ILE B 2 2   ? -4.706  -7.909  13.194  1.00 33.18 ? 2   ILE L N   1 
ATOM   1667 C CA  . ILE B 2 2   ? -4.387  -9.340  13.301  1.00 36.70 ? 2   ILE L CA  1 
ATOM   1668 C C   . ILE B 2 2   ? -5.273  -10.009 14.323  1.00 31.14 ? 2   ILE L C   1 
ATOM   1669 O O   . ILE B 2 2   ? -5.410  -9.524  15.442  1.00 33.80 ? 2   ILE L O   1 
ATOM   1670 C CB  . ILE B 2 2   ? -2.908  -9.598  13.666  1.00 35.85 ? 2   ILE L CB  1 
ATOM   1671 C CG1 . ILE B 2 2   ? -1.995  -9.264  12.495  1.00 34.40 ? 2   ILE L CG1 1 
ATOM   1672 C CG2 . ILE B 2 2   ? -2.697  -11.071 14.037  1.00 27.61 ? 2   ILE L CG2 1 
ATOM   1673 C CD1 . ILE B 2 2   ? -0.548  -9.233  12.889  1.00 36.94 ? 2   ILE L CD1 1 
ATOM   1674 N N   . GLN B 2 3   ? -5.858  -11.135 13.938  1.00 31.36 ? 3   GLN L N   1 
ATOM   1675 C CA  . GLN B 2 3   ? -6.770  -11.863 14.804  1.00 31.86 ? 3   GLN L CA  1 
ATOM   1676 C C   . GLN B 2 3   ? -6.008  -12.896 15.612  1.00 29.96 ? 3   GLN L C   1 
ATOM   1677 O O   . GLN B 2 3   ? -5.005  -13.445 15.157  1.00 32.71 ? 3   GLN L O   1 
ATOM   1678 C CB  . GLN B 2 3   ? -7.880  -12.540 13.999  1.00 33.97 ? 3   GLN L CB  1 
ATOM   1679 C CG  . GLN B 2 3   ? -9.098  -11.667 13.820  1.00 39.59 ? 3   GLN L CG  1 
ATOM   1680 C CD  . GLN B 2 3   ? -8.800  -10.476 12.948  1.00 42.98 ? 3   GLN L CD  1 
ATOM   1681 O OE1 . GLN B 2 3   ? -8.276  -10.619 11.842  1.00 37.71 ? 3   GLN L OE1 1 
ATOM   1682 N NE2 . GLN B 2 3   ? -9.117  -9.286  13.445  1.00 45.71 ? 3   GLN L NE2 1 
ATOM   1683 N N   . VAL B 2 4   ? -6.499  -13.143 16.825  1.00 27.74 ? 4   VAL L N   1 
ATOM   1684 C CA  . VAL B 2 4   ? -5.826  -13.962 17.827  1.00 34.26 ? 4   VAL L CA  1 
ATOM   1685 C C   . VAL B 2 4   ? -6.856  -14.884 18.464  1.00 32.57 ? 4   VAL L C   1 
ATOM   1686 O O   . VAL B 2 4   ? -7.921  -14.424 18.886  1.00 34.80 ? 4   VAL L O   1 
ATOM   1687 C CB  . VAL B 2 4   ? -5.164  -13.097 18.920  1.00 32.47 ? 4   VAL L CB  1 
ATOM   1688 C CG1 . VAL B 2 4   ? -4.647  -13.977 20.032  1.00 36.32 ? 4   VAL L CG1 1 
ATOM   1689 C CG2 . VAL B 2 4   ? -4.053  -12.204 18.338  1.00 28.35 ? 4   VAL L CG2 1 
ATOM   1690 N N   . THR B 2 5   ? -6.538  -16.173 18.562  1.00 28.67 ? 5   THR L N   1 
ATOM   1691 C CA  . THR B 2 5   ? -7.382  -17.128 19.284  1.00 33.20 ? 5   THR L CA  1 
ATOM   1692 C C   . THR B 2 5   ? -6.553  -17.737 20.396  1.00 26.08 ? 5   THR L C   1 
ATOM   1693 O O   . THR B 2 5   ? -5.609  -18.480 20.120  1.00 31.55 ? 5   THR L O   1 
ATOM   1694 C CB  . THR B 2 5   ? -7.908  -18.230 18.365  1.00 32.98 ? 5   THR L CB  1 
ATOM   1695 O OG1 . THR B 2 5   ? -8.778  -17.673 17.373  1.00 38.94 ? 5   THR L OG1 1 
ATOM   1696 C CG2 . THR B 2 5   ? -8.659  -19.286 19.169  1.00 34.04 ? 5   THR L CG2 1 
ATOM   1697 N N   . GLN B 2 6   ? -6.907  -17.445 21.643  1.00 30.37 ? 6   GLN L N   1 
ATOM   1698 C CA  . GLN B 2 6   ? -6.184  -17.957 22.801  1.00 27.19 ? 6   GLN L CA  1 
ATOM   1699 C C   . GLN B 2 6   ? -6.927  -19.145 23.409  1.00 32.71 ? 6   GLN L C   1 
ATOM   1700 O O   . GLN B 2 6   ? -8.141  -19.075 23.612  1.00 30.69 ? 6   GLN L O   1 
ATOM   1701 C CB  . GLN B 2 6   ? -5.996  -16.866 23.851  1.00 28.76 ? 6   GLN L CB  1 
ATOM   1702 C CG  . GLN B 2 6   ? -5.341  -17.379 25.133  1.00 26.20 ? 6   GLN L CG  1 
ATOM   1703 C CD  . GLN B 2 6   ? -4.974  -16.262 26.078  1.00 31.12 ? 6   GLN L CD  1 
ATOM   1704 O OE1 . GLN B 2 6   ? -4.977  -15.080 25.714  1.00 31.75 ? 6   GLN L OE1 1 
ATOM   1705 N NE2 . GLN B 2 6   ? -4.663  -16.624 27.305  1.00 32.14 ? 6   GLN L NE2 1 
ATOM   1706 N N   . SER B 2 7   ? -6.195  -20.219 23.721  1.00 29.85 ? 7   SER L N   1 
ATOM   1707 C CA  . SER B 2 7   ? -6.771  -21.466 24.217  1.00 33.00 ? 7   SER L CA  1 
ATOM   1708 C C   . SER B 2 7   ? -5.982  -22.010 25.392  1.00 32.01 ? 7   SER L C   1 
ATOM   1709 O O   . SER B 2 7   ? -4.756  -21.838 25.456  1.00 35.02 ? 7   SER L O   1 
ATOM   1710 C CB  . SER B 2 7   ? -6.806  -22.539 23.123  1.00 28.71 ? 7   SER L CB  1 
ATOM   1711 O OG  . SER B 2 7   ? -7.574  -22.061 22.046  1.00 48.52 ? 7   SER L OG  1 
ATOM   1712 N N   . PRO B 2 8   ? -6.657  -22.679 26.355  1.00 29.23 ? 8   PRO L N   1 
ATOM   1713 C CA  . PRO B 2 8   ? -8.118  -22.782 26.524  1.00 28.81 ? 8   PRO L CA  1 
ATOM   1714 C C   . PRO B 2 8   ? -8.643  -21.567 27.260  1.00 34.75 ? 8   PRO L C   1 
ATOM   1715 O O   . PRO B 2 8   ? -7.850  -20.816 27.848  1.00 33.39 ? 8   PRO L O   1 
ATOM   1716 C CB  . PRO B 2 8   ? -8.274  -24.054 27.361  1.00 32.18 ? 8   PRO L CB  1 
ATOM   1717 C CG  . PRO B 2 8   ? -7.049  -24.016 28.263  1.00 33.62 ? 8   PRO L CG  1 
ATOM   1718 C CD  . PRO B 2 8   ? -5.939  -23.440 27.400  1.00 29.80 ? 8   PRO L CD  1 
ATOM   1719 N N   . SER B 2 9   ? -9.958  -21.341 27.278  1.00 31.65 ? 9   SER L N   1 
ATOM   1720 C CA  . SER B 2 9   ? -10.469 -20.215 28.047  1.00 34.22 ? 9   SER L CA  1 
ATOM   1721 C C   . SER B 2 9   ? -10.253 -20.426 29.540  1.00 32.13 ? 9   SER L C   1 
ATOM   1722 O O   . SER B 2 9   ? -10.055 -19.456 30.278  1.00 34.30 ? 9   SER L O   1 
ATOM   1723 C CB  . SER B 2 9   ? -11.946 -19.989 27.736  1.00 36.91 ? 9   SER L CB  1 
ATOM   1724 O OG  . SER B 2 9   ? -12.712 -21.126 28.097  1.00 44.30 ? 9   SER L OG  1 
ATOM   1725 N N   . SER B 2 10  ? -10.258 -21.677 29.997  1.00 33.74 ? 10  SER L N   1 
ATOM   1726 C CA  . SER B 2 10  ? -9.984  -21.985 31.393  1.00 31.78 ? 10  SER L CA  1 
ATOM   1727 C C   . SER B 2 10  ? -9.449  -23.401 31.506  1.00 30.68 ? 10  SER L C   1 
ATOM   1728 O O   . SER B 2 10  ? -9.740  -24.272 30.681  1.00 33.94 ? 10  SER L O   1 
ATOM   1729 C CB  . SER B 2 10  ? -11.224 -21.831 32.282  1.00 38.35 ? 10  SER L CB  1 
ATOM   1730 O OG  . SER B 2 10  ? -12.072 -22.963 32.182  1.00 37.08 ? 10  SER L OG  1 
ATOM   1731 N N   . LEU B 2 11  ? -8.666  -23.613 32.549  1.00 28.71 ? 11  LEU L N   1 
ATOM   1732 C CA  . LEU B 2 11  ? -8.168  -24.932 32.873  1.00 36.87 ? 11  LEU L CA  1 
ATOM   1733 C C   . LEU B 2 11  ? -7.998  -24.986 34.379  1.00 38.06 ? 11  LEU L C   1 
ATOM   1734 O O   . LEU B 2 11  ? -7.888  -23.956 35.049  1.00 37.54 ? 11  LEU L O   1 
ATOM   1735 C CB  . LEU B 2 11  ? -6.854  -25.252 32.140  1.00 36.38 ? 11  LEU L CB  1 
ATOM   1736 C CG  . LEU B 2 11  ? -5.573  -24.487 32.484  1.00 31.69 ? 11  LEU L CG  1 
ATOM   1737 C CD1 . LEU B 2 11  ? -4.778  -25.169 33.598  1.00 38.35 ? 11  LEU L CD1 1 
ATOM   1738 C CD2 . LEU B 2 11  ? -4.699  -24.318 31.266  1.00 38.27 ? 11  LEU L CD2 1 
ATOM   1739 N N   . SER B 2 12  ? -8.020  -26.196 34.913  1.00 29.78 ? 12  SER L N   1 
ATOM   1740 C CA  . SER B 2 12  ? -7.773  -26.385 36.331  1.00 38.86 ? 12  SER L CA  1 
ATOM   1741 C C   . SER B 2 12  ? -6.639  -27.377 36.464  1.00 36.18 ? 12  SER L C   1 
ATOM   1742 O O   . SER B 2 12  ? -6.516  -28.298 35.653  1.00 34.92 ? 12  SER L O   1 
ATOM   1743 C CB  . SER B 2 12  ? -9.018  -26.878 37.076  1.00 36.61 ? 12  SER L CB  1 
ATOM   1744 O OG  . SER B 2 12  ? -9.360  -28.178 36.650  1.00 43.87 ? 12  SER L OG  1 
ATOM   1745 N N   . ALA B 2 13  ? -5.800  -27.171 37.466  1.00 34.62 ? 13  ALA L N   1 
ATOM   1746 C CA  . ALA B 2 13  ? -4.629  -28.016 37.640  1.00 38.26 ? 13  ALA L CA  1 
ATOM   1747 C C   . ALA B 2 13  ? -4.226  -27.944 39.104  1.00 40.04 ? 13  ALA L C   1 
ATOM   1748 O O   . ALA B 2 13  ? -4.812  -27.192 39.891  1.00 36.02 ? 13  ALA L O   1 
ATOM   1749 C CB  . ALA B 2 13  ? -3.496  -27.592 36.699  1.00 35.32 ? 13  ALA L CB  1 
ATOM   1750 N N   . SER B 2 14  ? -3.234  -28.757 39.464  1.00 36.88 ? 14  SER L N   1 
ATOM   1751 C CA  . SER B 2 14  ? -2.761  -28.876 40.836  1.00 41.76 ? 14  SER L CA  1 
ATOM   1752 C C   . SER B 2 14  ? -1.422  -28.179 40.991  1.00 38.37 ? 14  SER L C   1 
ATOM   1753 O O   . SER B 2 14  ? -0.670  -28.014 40.024  1.00 36.73 ? 14  SER L O   1 
ATOM   1754 C CB  . SER B 2 14  ? -2.598  -30.345 41.249  1.00 36.04 ? 14  SER L CB  1 
ATOM   1755 O OG  . SER B 2 14  ? -3.842  -30.977 41.331  1.00 38.95 ? 14  SER L OG  1 
ATOM   1756 N N   . VAL B 2 15  ? -1.124  -27.782 42.231  1.00 38.22 ? 15  VAL L N   1 
ATOM   1757 C CA  . VAL B 2 15  ? 0.208   -27.277 42.516  1.00 34.65 ? 15  VAL L CA  1 
ATOM   1758 C C   . VAL B 2 15  ? 1.217   -28.292 42.012  1.00 39.40 ? 15  VAL L C   1 
ATOM   1759 O O   . VAL B 2 15  ? 1.050   -29.500 42.204  1.00 34.53 ? 15  VAL L O   1 
ATOM   1760 C CB  . VAL B 2 15  ? 0.391   -27.012 44.020  1.00 32.36 ? 15  VAL L CB  1 
ATOM   1761 C CG1 . VAL B 2 15  ? 1.864   -26.682 44.314  1.00 35.93 ? 15  VAL L CG1 1 
ATOM   1762 C CG2 . VAL B 2 15  ? -0.506  -25.902 44.490  1.00 35.19 ? 15  VAL L CG2 1 
ATOM   1763 N N   . GLY B 2 16  ? 2.226   -27.813 41.302  1.00 35.54 ? 16  GLY L N   1 
ATOM   1764 C CA  . GLY B 2 16  ? 3.315   -28.639 40.866  1.00 39.25 ? 16  GLY L CA  1 
ATOM   1765 C C   . GLY B 2 16  ? 3.189   -29.243 39.484  1.00 40.58 ? 16  GLY L C   1 
ATOM   1766 O O   . GLY B 2 16  ? 4.207   -29.659 38.918  1.00 47.62 ? 16  GLY L O   1 
ATOM   1767 N N   . ASP B 2 17  ? 2.001   -29.309 38.901  1.00 34.08 ? 17  ASP L N   1 
ATOM   1768 C CA  . ASP B 2 17  ? 1.996   -29.911 37.577  1.00 46.17 ? 17  ASP L CA  1 
ATOM   1769 C C   . ASP B 2 17  ? 2.155   -28.834 36.490  1.00 43.61 ? 17  ASP L C   1 
ATOM   1770 O O   . ASP B 2 17  ? 2.235   -27.628 36.755  1.00 39.06 ? 17  ASP L O   1 
ATOM   1771 C CB  . ASP B 2 17  ? 0.773   -30.824 37.382  1.00 50.92 ? 17  ASP L CB  1 
ATOM   1772 C CG  . ASP B 2 17  ? -0.541  -30.129 37.600  1.00 50.86 ? 17  ASP L CG  1 
ATOM   1773 O OD1 . ASP B 2 17  ? -0.556  -28.885 37.526  1.00 55.64 ? 17  ASP L OD1 1 
ATOM   1774 O OD2 . ASP B 2 17  ? -1.562  -30.830 37.836  1.00 42.78 ? 17  ASP L OD2 1 
ATOM   1775 N N   . ARG B 2 18  ? 2.268   -29.291 35.250  1.00 41.91 ? 18  ARG L N   1 
ATOM   1776 C CA  . ARG B 2 18  ? 2.703   -28.465 34.134  1.00 40.54 ? 18  ARG L CA  1 
ATOM   1777 C C   . ARG B 2 18  ? 1.491   -28.078 33.297  1.00 35.09 ? 18  ARG L C   1 
ATOM   1778 O O   . ARG B 2 18  ? 0.705   -28.945 32.916  1.00 38.09 ? 18  ARG L O   1 
ATOM   1779 C CB  . ARG B 2 18  ? 3.724   -29.241 33.300  1.00 40.96 ? 18  ARG L CB  1 
ATOM   1780 C CG  . ARG B 2 18  ? 4.301   -28.537 32.087  1.00 41.58 ? 18  ARG L CG  1 
ATOM   1781 C CD  . ARG B 2 18  ? 5.027   -29.568 31.234  1.00 48.48 ? 18  ARG L CD  1 
ATOM   1782 N NE  . ARG B 2 18  ? 5.932   -28.987 30.251  1.00 60.62 ? 18  ARG L NE  1 
ATOM   1783 C CZ  . ARG B 2 18  ? 5.722   -28.993 28.940  1.00 63.14 ? 18  ARG L CZ  1 
ATOM   1784 N NH1 . ARG B 2 18  ? 4.629   -29.530 28.413  1.00 58.09 ? 18  ARG L NH1 1 
ATOM   1785 N NH2 . ARG B 2 18  ? 6.634   -28.450 28.135  1.00 61.53 ? 18  ARG L NH2 1 
ATOM   1786 N N   . VAL B 2 19  ? 1.341   -26.779 33.022  1.00 34.49 ? 19  VAL L N   1 
ATOM   1787 C CA  . VAL B 2 19  ? 0.234   -26.260 32.229  1.00 31.81 ? 19  VAL L CA  1 
ATOM   1788 C C   . VAL B 2 19  ? 0.780   -25.503 31.023  1.00 35.37 ? 19  VAL L C   1 
ATOM   1789 O O   . VAL B 2 19  ? 1.857   -24.897 31.065  1.00 32.42 ? 19  VAL L O   1 
ATOM   1790 C CB  . VAL B 2 19  ? -0.704  -25.353 33.055  1.00 34.16 ? 19  VAL L CB  1 
ATOM   1791 C CG1 . VAL B 2 19  ? -1.373  -26.151 34.156  1.00 38.42 ? 19  VAL L CG1 1 
ATOM   1792 C CG2 . VAL B 2 19  ? 0.054   -24.162 33.623  1.00 31.91 ? 19  VAL L CG2 1 
ATOM   1793 N N   . THR B 2 20  ? 0.009   -25.535 29.942  1.00 38.53 ? 20  THR L N   1 
ATOM   1794 C CA  . THR B 2 20  ? 0.400   -24.952 28.670  1.00 38.31 ? 20  THR L CA  1 
ATOM   1795 C C   . THR B 2 20  ? -0.766  -24.144 28.123  1.00 38.89 ? 20  THR L C   1 
ATOM   1796 O O   . THR B 2 20  ? -1.893  -24.641 28.075  1.00 40.30 ? 20  THR L O   1 
ATOM   1797 C CB  . THR B 2 20  ? 0.809   -26.054 27.692  1.00 39.33 ? 20  THR L CB  1 
ATOM   1798 O OG1 . THR B 2 20  ? 2.143   -26.485 27.995  1.00 42.68 ? 20  THR L OG1 1 
ATOM   1799 C CG2 . THR B 2 20  ? 0.740   -25.564 26.271  1.00 44.56 ? 20  THR L CG2 1 
ATOM   1800 N N   . ILE B 2 21  ? -0.495  -22.901 27.726  1.00 35.82 ? 21  ILE L N   1 
ATOM   1801 C CA  . ILE B 2 21  ? -1.499  -21.962 27.231  1.00 34.04 ? 21  ILE L CA  1 
ATOM   1802 C C   . ILE B 2 21  ? -1.053  -21.515 25.845  1.00 32.41 ? 21  ILE L C   1 
ATOM   1803 O O   . ILE B 2 21  ? 0.110   -21.150 25.656  1.00 28.90 ? 21  ILE L O   1 
ATOM   1804 C CB  . ILE B 2 21  ? -1.650  -20.749 28.173  1.00 31.75 ? 21  ILE L CB  1 
ATOM   1805 C CG1 . ILE B 2 21  ? -2.248  -21.169 29.513  1.00 30.76 ? 21  ILE L CG1 1 
ATOM   1806 C CG2 . ILE B 2 21  ? -2.476  -19.631 27.538  1.00 28.10 ? 21  ILE L CG2 1 
ATOM   1807 C CD1 . ILE B 2 21  ? -2.114  -20.104 30.572  1.00 31.07 ? 21  ILE L CD1 1 
ATOM   1808 N N   . THR B 2 22  ? -1.957  -21.551 24.877  1.00 27.75 ? 22  THR L N   1 
ATOM   1809 C CA  . THR B 2 22  ? -1.536  -21.232 23.530  1.00 30.43 ? 22  THR L CA  1 
ATOM   1810 C C   . THR B 2 22  ? -2.307  -20.048 22.961  1.00 28.79 ? 22  THR L C   1 
ATOM   1811 O O   . THR B 2 22  ? -3.441  -19.742 23.343  1.00 32.39 ? 22  THR L O   1 
ATOM   1812 C CB  . THR B 2 22  ? -1.670  -22.437 22.601  1.00 34.05 ? 22  THR L CB  1 
ATOM   1813 O OG1 . THR B 2 22  ? -3.048  -22.680 22.353  1.00 40.39 ? 22  THR L OG1 1 
ATOM   1814 C CG2 . THR B 2 22  ? -1.079  -23.663 23.254  1.00 35.74 ? 22  THR L CG2 1 
ATOM   1815 N N   . CYS B 2 23  ? -1.660  -19.416 22.000  1.00 29.76 ? 23  CYS L N   1 
ATOM   1816 C CA  . CYS B 2 23  ? -2.147  -18.217 21.343  1.00 31.44 ? 23  CYS L CA  1 
ATOM   1817 C C   . CYS B 2 23  ? -1.845  -18.388 19.860  1.00 30.72 ? 23  CYS L C   1 
ATOM   1818 O O   . CYS B 2 23  ? -0.691  -18.626 19.492  1.00 31.16 ? 23  CYS L O   1 
ATOM   1819 C CB  . CYS B 2 23  ? -1.440  -17.000 21.947  1.00 33.21 ? 23  CYS L CB  1 
ATOM   1820 S SG  . CYS B 2 23  ? -1.962  -15.367 21.467  1.00 62.64 ? 23  CYS L SG  1 
ATOM   1821 N N   . ARG B 2 24  ? -2.877  -18.340 19.019  1.00 31.27 ? 24  ARG L N   1 
ATOM   1822 C CA  . ARG B 2 24  ? -2.721  -18.488 17.577  1.00 34.82 ? 24  ARG L CA  1 
ATOM   1823 C C   . ARG B 2 24  ? -3.039  -17.166 16.891  1.00 31.96 ? 24  ARG L C   1 
ATOM   1824 O O   . ARG B 2 24  ? -4.056  -16.540 17.198  1.00 30.73 ? 24  ARG L O   1 
ATOM   1825 C CB  . ARG B 2 24  ? -3.624  -19.597 17.031  1.00 33.79 ? 24  ARG L CB  1 
ATOM   1826 C CG  . ARG B 2 24  ? -3.326  -19.980 15.569  1.00 48.09 ? 24  ARG L CG  1 
ATOM   1827 C CD  . ARG B 2 24  ? -3.959  -21.302 15.195  1.00 46.93 ? 24  ARG L CD  1 
ATOM   1828 N NE  . ARG B 2 24  ? -4.055  -22.149 16.377  1.00 59.16 ? 24  ARG L NE  1 
ATOM   1829 C CZ  . ARG B 2 24  ? -3.243  -23.162 16.646  1.00 65.28 ? 24  ARG L CZ  1 
ATOM   1830 N NH1 . ARG B 2 24  ? -2.290  -23.523 15.803  1.00 66.57 ? 24  ARG L NH1 1 
ATOM   1831 N NH2 . ARG B 2 24  ? -3.399  -23.836 17.784  1.00 61.07 ? 24  ARG L NH2 1 
ATOM   1832 N N   . ALA B 2 25  ? -2.183  -16.756 15.958  1.00 29.21 ? 25  ALA L N   1 
ATOM   1833 C CA  . ALA B 2 25  ? -2.385  -15.541 15.182  1.00 30.97 ? 25  ALA L CA  1 
ATOM   1834 C C   . ALA B 2 25  ? -2.873  -15.863 13.772  1.00 37.58 ? 25  ALA L C   1 
ATOM   1835 O O   . ALA B 2 25  ? -2.523  -16.894 13.194  1.00 35.52 ? 25  ALA L O   1 
ATOM   1836 C CB  . ALA B 2 25  ? -1.097  -14.722 15.097  1.00 27.50 ? 25  ALA L CB  1 
ATOM   1837 N N   . SER B 2 26  ? -3.677  -14.949 13.213  1.00 36.30 ? 26  SER L N   1 
ATOM   1838 C CA  . SER B 2 26  ? -4.210  -15.127 11.864  1.00 37.46 ? 26  SER L CA  1 
ATOM   1839 C C   . SER B 2 26  ? -3.165  -14.950 10.767  1.00 35.60 ? 26  SER L C   1 
ATOM   1840 O O   . SER B 2 26  ? -3.491  -15.167 9.597   1.00 36.15 ? 26  SER L O   1 
ATOM   1841 C CB  . SER B 2 26  ? -5.360  -14.158 11.619  1.00 33.62 ? 26  SER L CB  1 
ATOM   1842 O OG  . SER B 2 26  ? -4.956  -12.833 11.873  1.00 36.44 ? 26  SER L OG  1 
ATOM   1843 N N   . GLN B 2 27  ? -1.937  -14.552 11.099  1.00 35.36 ? 27  GLN L N   1 
ATOM   1844 C CA  . GLN B 2 27  ? -0.850  -14.547 10.128  1.00 38.83 ? 27  GLN L CA  1 
ATOM   1845 C C   . GLN B 2 27  ? 0.479   -14.515 10.876  1.00 32.86 ? 27  GLN L C   1 
ATOM   1846 O O   . GLN B 2 27  ? 0.520   -14.285 12.086  1.00 35.06 ? 27  GLN L O   1 
ATOM   1847 C CB  . GLN B 2 27  ? -0.966  -13.365 9.166   1.00 35.28 ? 27  GLN L CB  1 
ATOM   1848 C CG  . GLN B 2 27  ? -0.821  -12.033 9.852   1.00 37.10 ? 27  GLN L CG  1 
ATOM   1849 C CD  . GLN B 2 27  ? 0.030   -11.070 9.045   1.00 47.59 ? 27  GLN L CD  1 
ATOM   1850 O OE1 . GLN B 2 27  ? -0.466  -10.050 8.577   1.00 42.34 ? 27  GLN L OE1 1 
ATOM   1851 N NE2 . GLN B 2 27  ? 1.320   -11.398 8.870   1.00 44.28 ? 27  GLN L NE2 1 
ATOM   1852 N N   . GLY B 2 28  ? 1.560   -14.746 10.140  1.00 29.69 ? 28  GLY L N   1 
ATOM   1853 C CA  . GLY B 2 28  ? 2.878   -14.779 10.762  1.00 29.92 ? 28  GLY L CA  1 
ATOM   1854 C C   . GLY B 2 28  ? 3.225   -13.451 11.413  1.00 35.45 ? 28  GLY L C   1 
ATOM   1855 O O   . GLY B 2 28  ? 2.967   -12.378 10.859  1.00 40.29 ? 28  GLY L O   1 
ATOM   1856 N N   . ILE B 2 29  ? 3.812   -13.522 12.614  1.00 31.96 ? 29  ILE L N   1 
ATOM   1857 C CA  . ILE B 2 29  ? 4.078   -12.306 13.383  1.00 37.05 ? 29  ILE L CA  1 
ATOM   1858 C C   . ILE B 2 29  ? 5.512   -12.234 13.891  1.00 38.72 ? 29  ILE L C   1 
ATOM   1859 O O   . ILE B 2 29  ? 5.815   -11.414 14.766  1.00 37.62 ? 29  ILE L O   1 
ATOM   1860 C CB  . ILE B 2 29  ? 3.112   -12.184 14.578  1.00 40.00 ? 29  ILE L CB  1 
ATOM   1861 C CG1 . ILE B 2 29  ? 3.375   -13.311 15.581  1.00 36.24 ? 29  ILE L CG1 1 
ATOM   1862 C CG2 . ILE B 2 29  ? 1.679   -12.237 14.114  1.00 34.25 ? 29  ILE L CG2 1 
ATOM   1863 C CD1 . ILE B 2 29  ? 2.894   -13.000 16.973  1.00 34.56 ? 29  ILE L CD1 1 
ATOM   1864 N N   . SER B 2 30  ? 6.399   -13.073 13.358  1.00 36.09 ? 30  SER L N   1 
ATOM   1865 C CA  . SER B 2 30  ? 7.787   -13.193 13.855  1.00 42.73 ? 30  SER L CA  1 
ATOM   1866 C C   . SER B 2 30  ? 7.688   -13.644 15.309  1.00 39.48 ? 30  SER L C   1 
ATOM   1867 O O   . SER B 2 30  ? 7.068   -14.685 15.588  1.00 44.46 ? 30  SER L O   1 
ATOM   1868 C CB  . SER B 2 30  ? 8.575   -11.904 13.637  1.00 42.54 ? 30  SER L CB  1 
ATOM   1869 O OG  . SER B 2 30  ? 8.521   -11.485 12.294  1.00 44.74 ? 30  SER L OG  1 
ATOM   1870 N N   . ASN B 2 31  ? 8.279   -12.935 16.254  1.00 36.32 ? 31  ASN L N   1 
ATOM   1871 C CA  . ASN B 2 31  ? 8.066   -13.210 17.663  1.00 36.10 ? 31  ASN L CA  1 
ATOM   1872 C C   . ASN B 2 31  ? 7.498   -11.978 18.359  1.00 35.24 ? 31  ASN L C   1 
ATOM   1873 O O   . ASN B 2 31  ? 7.846   -11.665 19.503  1.00 30.92 ? 31  ASN L O   1 
ATOM   1874 C CB  . ASN B 2 31  ? 9.361   -13.681 18.322  1.00 41.29 ? 31  ASN L CB  1 
ATOM   1875 C CG  . ASN B 2 31  ? 10.468  -12.642 18.249  1.00 43.75 ? 31  ASN L CG  1 
ATOM   1876 O OD1 . ASN B 2 31  ? 10.371  -11.656 17.513  1.00 43.29 ? 31  ASN L OD1 1 
ATOM   1877 N ND2 . ASN B 2 31  ? 11.538  -12.868 19.005  1.00 48.48 ? 31  ASN L ND2 1 
ATOM   1878 N N   . TYR B 2 32  ? 6.607   -11.254 17.673  1.00 29.60 ? 32  TYR L N   1 
ATOM   1879 C CA  . TYR B 2 32  ? 6.097   -9.988  18.207  1.00 26.70 ? 32  TYR L CA  1 
ATOM   1880 C C   . TYR B 2 32  ? 4.883   -10.290 19.084  1.00 29.53 ? 32  TYR L C   1 
ATOM   1881 O O   . TYR B 2 32  ? 3.730   -10.075 18.707  1.00 27.50 ? 32  TYR L O   1 
ATOM   1882 C CB  . TYR B 2 32  ? 5.772   -9.019  17.074  1.00 30.85 ? 32  TYR L CB  1 
ATOM   1883 C CG  . TYR B 2 32  ? 5.767   -7.575  17.523  1.00 31.65 ? 32  TYR L CG  1 
ATOM   1884 C CD1 . TYR B 2 32  ? 6.941   -6.847  17.561  1.00 28.98 ? 32  TYR L CD1 1 
ATOM   1885 C CD2 . TYR B 2 32  ? 4.602   -6.957  17.941  1.00 25.30 ? 32  TYR L CD2 1 
ATOM   1886 C CE1 . TYR B 2 32  ? 6.964   -5.553  17.976  1.00 27.65 ? 32  TYR L CE1 1 
ATOM   1887 C CE2 . TYR B 2 32  ? 4.616   -5.652  18.364  1.00 28.83 ? 32  TYR L CE2 1 
ATOM   1888 C CZ  . TYR B 2 32  ? 5.809   -4.947  18.380  1.00 27.23 ? 32  TYR L CZ  1 
ATOM   1889 O OH  . TYR B 2 32  ? 5.866   -3.632  18.799  1.00 21.32 ? 32  TYR L OH  1 
ATOM   1890 N N   . LEU B 2 33  ? 5.163   -10.798 20.287  1.00 26.15 ? 33  LEU L N   1 
ATOM   1891 C CA  . LEU B 2 33  ? 4.136   -11.265 21.207  1.00 27.04 ? 33  LEU L CA  1 
ATOM   1892 C C   . LEU B 2 33  ? 4.645   -11.067 22.628  1.00 27.65 ? 33  LEU L C   1 
ATOM   1893 O O   . LEU B 2 33  ? 5.855   -11.069 22.871  1.00 27.57 ? 33  LEU L O   1 
ATOM   1894 C CB  . LEU B 2 33  ? 3.757   -12.738 20.941  1.00 25.82 ? 33  LEU L CB  1 
ATOM   1895 C CG  . LEU B 2 33  ? 2.798   -13.483 21.884  1.00 28.41 ? 33  LEU L CG  1 
ATOM   1896 C CD1 . LEU B 2 33  ? 2.058   -14.605 21.163  1.00 29.16 ? 33  LEU L CD1 1 
ATOM   1897 C CD2 . LEU B 2 33  ? 3.527   -14.054 23.116  1.00 29.33 ? 33  LEU L CD2 1 
ATOM   1898 N N   . ALA B 2 34  ? 3.709   -10.826 23.550  1.00 28.31 ? 34  ALA L N   1 
ATOM   1899 C CA  . ALA B 2 34  ? 3.987   -10.759 24.976  1.00 25.82 ? 34  ALA L CA  1 
ATOM   1900 C C   . ALA B 2 34  ? 2.907   -11.516 25.728  1.00 29.53 ? 34  ALA L C   1 
ATOM   1901 O O   . ALA B 2 34  ? 1.765   -11.615 25.270  1.00 25.09 ? 34  ALA L O   1 
ATOM   1902 C CB  . ALA B 2 34  ? 4.041   -9.320  25.526  1.00 24.79 ? 34  ALA L CB  1 
ATOM   1903 N N   . TRP B 2 35  ? 3.282   -12.026 26.899  1.00 29.55 ? 35  TRP L N   1 
ATOM   1904 C CA  . TRP B 2 35  ? 2.367   -12.656 27.840  1.00 28.55 ? 35  TRP L CA  1 
ATOM   1905 C C   . TRP B 2 35  ? 2.323   -11.822 29.103  1.00 25.13 ? 35  TRP L C   1 
ATOM   1906 O O   . TRP B 2 35  ? 3.369   -11.366 29.589  1.00 24.31 ? 35  TRP L O   1 
ATOM   1907 C CB  . TRP B 2 35  ? 2.804   -14.070 28.213  1.00 28.70 ? 35  TRP L CB  1 
ATOM   1908 C CG  . TRP B 2 35  ? 2.752   -15.050 27.132  1.00 25.98 ? 35  TRP L CG  1 
ATOM   1909 C CD1 . TRP B 2 35  ? 3.794   -15.455 26.353  1.00 28.79 ? 35  TRP L CD1 1 
ATOM   1910 C CD2 . TRP B 2 35  ? 1.603   -15.790 26.691  1.00 26.39 ? 35  TRP L CD2 1 
ATOM   1911 N NE1 . TRP B 2 35  ? 3.365   -16.393 25.445  1.00 29.64 ? 35  TRP L NE1 1 
ATOM   1912 C CE2 . TRP B 2 35  ? 2.027   -16.624 25.634  1.00 27.70 ? 35  TRP L CE2 1 
ATOM   1913 C CE3 . TRP B 2 35  ? 0.260   -15.821 27.076  1.00 23.37 ? 35  TRP L CE3 1 
ATOM   1914 C CZ2 . TRP B 2 35  ? 1.156   -17.498 24.961  1.00 26.88 ? 35  TRP L CZ2 1 
ATOM   1915 C CZ3 . TRP B 2 35  ? -0.610  -16.691 26.406  1.00 28.44 ? 35  TRP L CZ3 1 
ATOM   1916 C CH2 . TRP B 2 35  ? -0.154  -17.517 25.361  1.00 28.58 ? 35  TRP L CH2 1 
ATOM   1917 N N   . TYR B 2 36  ? 1.109   -11.640 29.628  1.00 22.33 ? 36  TYR L N   1 
ATOM   1918 C CA  . TYR B 2 36  ? 0.849   -10.909 30.858  1.00 24.39 ? 36  TYR L CA  1 
ATOM   1919 C C   . TYR B 2 36  ? 0.068   -11.798 31.825  1.00 24.80 ? 36  TYR L C   1 
ATOM   1920 O O   . TYR B 2 36  ? -0.680  -12.685 31.408  1.00 26.04 ? 36  TYR L O   1 
ATOM   1921 C CB  . TYR B 2 36  ? 0.042   -9.609  30.603  1.00 23.07 ? 36  TYR L CB  1 
ATOM   1922 C CG  . TYR B 2 36  ? 0.715   -8.662  29.634  1.00 25.50 ? 36  TYR L CG  1 
ATOM   1923 C CD1 . TYR B 2 36  ? 0.579   -8.830  28.264  1.00 23.96 ? 36  TYR L CD1 1 
ATOM   1924 C CD2 . TYR B 2 36  ? 1.514   -7.616  30.091  1.00 24.23 ? 36  TYR L CD2 1 
ATOM   1925 C CE1 . TYR B 2 36  ? 1.221   -7.978  27.365  1.00 23.13 ? 36  TYR L CE1 1 
ATOM   1926 C CE2 . TYR B 2 36  ? 2.164   -6.764  29.198  1.00 25.93 ? 36  TYR L CE2 1 
ATOM   1927 C CZ  . TYR B 2 36  ? 2.011   -6.957  27.846  1.00 20.11 ? 36  TYR L CZ  1 
ATOM   1928 O OH  . TYR B 2 36  ? 2.647   -6.124  26.982  1.00 24.47 ? 36  TYR L OH  1 
ATOM   1929 N N   . GLN B 2 37  ? 0.236   -11.529 33.119  1.00 24.56 ? 37  GLN L N   1 
ATOM   1930 C CA  . GLN B 2 37  ? -0.513  -12.171 34.187  1.00 30.03 ? 37  GLN L CA  1 
ATOM   1931 C C   . GLN B 2 37  ? -1.401  -11.139 34.875  1.00 25.24 ? 37  GLN L C   1 
ATOM   1932 O O   . GLN B 2 37  ? -0.974  -10.011 35.123  1.00 29.42 ? 37  GLN L O   1 
ATOM   1933 C CB  . GLN B 2 37  ? 0.432   -12.797 35.211  1.00 26.45 ? 37  GLN L CB  1 
ATOM   1934 C CG  . GLN B 2 37  ? -0.245  -13.587 36.304  1.00 27.40 ? 37  GLN L CG  1 
ATOM   1935 C CD  . GLN B 2 37  ? 0.723   -13.996 37.402  1.00 28.87 ? 37  GLN L CD  1 
ATOM   1936 O OE1 . GLN B 2 37  ? 1.329   -13.143 38.064  1.00 34.00 ? 37  GLN L OE1 1 
ATOM   1937 N NE2 . GLN B 2 37  ? 0.885   -15.303 37.595  1.00 25.12 ? 37  GLN L NE2 1 
ATOM   1938 N N   . GLN B 2 38  ? -2.632  -11.521 35.187  1.00 22.91 ? 38  GLN L N   1 
ATOM   1939 C CA  . GLN B 2 38  ? -3.504  -10.630 35.933  1.00 28.67 ? 38  GLN L CA  1 
ATOM   1940 C C   . GLN B 2 38  ? -4.264  -11.416 36.992  1.00 32.14 ? 38  GLN L C   1 
ATOM   1941 O O   . GLN B 2 38  ? -4.862  -12.454 36.697  1.00 27.69 ? 38  GLN L O   1 
ATOM   1942 C CB  . GLN B 2 38  ? -4.489  -9.892  35.019  1.00 30.11 ? 38  GLN L CB  1 
ATOM   1943 C CG  . GLN B 2 38  ? -5.143  -8.689  35.725  1.00 30.33 ? 38  GLN L CG  1 
ATOM   1944 C CD  . GLN B 2 38  ? -6.230  -8.002  34.899  1.00 25.98 ? 38  GLN L CD  1 
ATOM   1945 O OE1 . GLN B 2 38  ? -6.822  -8.602  34.012  1.00 27.63 ? 38  GLN L OE1 1 
ATOM   1946 N NE2 . GLN B 2 38  ? -6.489  -6.742  35.199  1.00 26.74 ? 38  GLN L NE2 1 
ATOM   1947 N N   . LYS B 2 39  ? -4.223  -10.944 38.166  1.00 31.97 ? 39  LYS L N   1 
ATOM   1948 C CA  . LYS B 2 39  ? -4.991  -11.480 39.278  1.00 33.33 ? 39  LYS L CA  1 
ATOM   1949 C C   . LYS B 2 39  ? -6.199  -10.588 39.558  1.00 38.86 ? 39  LYS L C   1 
ATOM   1950 O O   . LYS B 2 39  ? -6.174  -9.392  39.242  1.00 34.40 ? 39  LYS L O   1 
ATOM   1951 C CB  . LYS B 2 39  ? -4.107  -11.565 40.522  1.00 37.42 ? 39  LYS L CB  1 
ATOM   1952 C CG  . LYS B 2 39  ? -3.009  -12.618 40.420  1.00 42.26 ? 39  LYS L CG  1 
ATOM   1953 C CD  . LYS B 2 39  ? -1.928  -12.365 41.460  1.00 42.18 ? 39  LYS L CD  1 
ATOM   1954 C CE  . LYS B 2 39  ? -0.943  -13.515 41.534  1.00 46.37 ? 39  LYS L CE  1 
ATOM   1955 N NZ  . LYS B 2 39  ? -1.529  -14.655 42.286  1.00 47.07 ? 39  LYS L NZ  1 
ATOM   1956 N N   . PRO B 2 40  ? -7.280  -11.120 40.139  1.00 43.70 ? 40  PRO L N   1 
ATOM   1957 C CA  . PRO B 2 40  ? -8.500  -10.311 40.283  1.00 40.40 ? 40  PRO L CA  1 
ATOM   1958 C C   . PRO B 2 40  ? -8.214  -9.032  41.057  1.00 34.72 ? 40  PRO L C   1 
ATOM   1959 O O   . PRO B 2 40  ? -7.497  -9.043  42.059  1.00 35.92 ? 40  PRO L O   1 
ATOM   1960 C CB  . PRO B 2 40  ? -9.459  -11.242 41.041  1.00 47.11 ? 40  PRO L CB  1 
ATOM   1961 C CG  . PRO B 2 40  ? -8.928  -12.626 40.801  1.00 44.41 ? 40  PRO L CG  1 
ATOM   1962 C CD  . PRO B 2 40  ? -7.437  -12.469 40.716  1.00 39.36 ? 40  PRO L CD  1 
ATOM   1963 N N   . GLY B 2 41  ? -8.737  -7.915  40.547  1.00 37.31 ? 41  GLY L N   1 
ATOM   1964 C CA  . GLY B 2 41  ? -8.524  -6.623  41.182  1.00 40.48 ? 41  GLY L CA  1 
ATOM   1965 C C   . GLY B 2 41  ? -7.109  -6.083  41.132  1.00 42.49 ? 41  GLY L C   1 
ATOM   1966 O O   . GLY B 2 41  ? -6.813  -5.090  41.804  1.00 42.98 ? 41  GLY L O   1 
ATOM   1967 N N   . LYS B 2 42  ? -6.222  -6.687  40.355  1.00 35.27 ? 42  LYS L N   1 
ATOM   1968 C CA  . LYS B 2 42  ? -4.842  -6.234  40.290  1.00 36.23 ? 42  LYS L CA  1 
ATOM   1969 C C   . LYS B 2 42  ? -4.516  -5.839  38.860  1.00 32.58 ? 42  LYS L C   1 
ATOM   1970 O O   . LYS B 2 42  ? -5.275  -6.101  37.924  1.00 35.28 ? 42  LYS L O   1 
ATOM   1971 C CB  . LYS B 2 42  ? -3.864  -7.316  40.781  1.00 41.05 ? 42  LYS L CB  1 
ATOM   1972 C CG  . LYS B 2 42  ? -4.258  -7.966  42.118  1.00 37.63 ? 42  LYS L CG  1 
ATOM   1973 C CD  . LYS B 2 42  ? -3.867  -7.105  43.292  1.00 41.01 ? 42  LYS L CD  1 
ATOM   1974 C CE  . LYS B 2 42  ? -2.534  -7.548  43.890  1.00 47.50 ? 42  LYS L CE  1 
ATOM   1975 N NZ  . LYS B 2 42  ? -2.136  -6.699  45.064  1.00 52.43 ? 42  LYS L NZ  1 
ATOM   1976 N N   . VAL B 2 43  ? -3.361  -5.206  38.711  1.00 32.29 ? 43  VAL L N   1 
ATOM   1977 C CA  . VAL B 2 43  ? -2.912  -4.615  37.457  1.00 30.17 ? 43  VAL L CA  1 
ATOM   1978 C C   . VAL B 2 43  ? -2.303  -5.726  36.612  1.00 28.39 ? 43  VAL L C   1 
ATOM   1979 O O   . VAL B 2 43  ? -1.666  -6.619  37.173  1.00 26.83 ? 43  VAL L O   1 
ATOM   1980 C CB  . VAL B 2 43  ? -1.912  -3.490  37.755  1.00 30.90 ? 43  VAL L CB  1 
ATOM   1981 C CG1 . VAL B 2 43  ? -1.205  -3.049  36.516  1.00 35.83 ? 43  VAL L CG1 1 
ATOM   1982 C CG2 . VAL B 2 43  ? -2.639  -2.323  38.427  1.00 30.38 ? 43  VAL L CG2 1 
ATOM   1983 N N   . PRO B 2 44  ? -2.470  -5.738  35.291  1.00 27.49 ? 44  PRO L N   1 
ATOM   1984 C CA  . PRO B 2 44  ? -1.727  -6.713  34.481  1.00 27.34 ? 44  PRO L CA  1 
ATOM   1985 C C   . PRO B 2 44  ? -0.229  -6.551  34.688  1.00 25.66 ? 44  PRO L C   1 
ATOM   1986 O O   . PRO B 2 44  ? 0.275   -5.447  34.890  1.00 28.23 ? 44  PRO L O   1 
ATOM   1987 C CB  . PRO B 2 44  ? -2.141  -6.378  33.040  1.00 27.15 ? 44  PRO L CB  1 
ATOM   1988 C CG  . PRO B 2 44  ? -3.543  -5.796  33.191  1.00 23.65 ? 44  PRO L CG  1 
ATOM   1989 C CD  . PRO B 2 44  ? -3.420  -4.951  34.476  1.00 28.24 ? 44  PRO L CD  1 
ATOM   1990 N N   . LYS B 2 45  ? 0.477   -7.676  34.661  1.00 27.28 ? 45  LYS L N   1 
ATOM   1991 C CA  . LYS B 2 45  ? 1.917   -7.713  34.888  1.00 29.05 ? 45  LYS L CA  1 
ATOM   1992 C C   . LYS B 2 45  ? 2.597   -8.437  33.734  1.00 28.76 ? 45  LYS L C   1 
ATOM   1993 O O   . LYS B 2 45  ? 2.207   -9.556  33.377  1.00 26.23 ? 45  LYS L O   1 
ATOM   1994 C CB  . LYS B 2 45  ? 2.244   -8.407  36.217  1.00 30.22 ? 45  LYS L CB  1 
ATOM   1995 C CG  . LYS B 2 45  ? 3.647   -8.985  36.330  1.00 34.60 ? 45  LYS L CG  1 
ATOM   1996 C CD  . LYS B 2 45  ? 3.784   -9.770  37.652  1.00 36.54 ? 45  LYS L CD  1 
ATOM   1997 C CE  . LYS B 2 45  ? 5.236   -10.219 37.923  1.00 34.38 ? 45  LYS L CE  1 
ATOM   1998 N NZ  . LYS B 2 45  ? 5.479   -10.384 39.382  1.00 39.97 ? 45  LYS L NZ  1 
ATOM   1999 N N   . LEU B 2 46  ? 3.627   -7.799  33.170  1.00 25.59 ? 46  LEU L N   1 
ATOM   2000 C CA  . LEU B 2 46  ? 4.369   -8.377  32.061  1.00 24.52 ? 46  LEU L CA  1 
ATOM   2001 C C   . LEU B 2 46  ? 5.217   -9.557  32.543  1.00 29.53 ? 46  LEU L C   1 
ATOM   2002 O O   . LEU B 2 46  ? 5.951   -9.443  33.530  1.00 24.70 ? 46  LEU L O   1 
ATOM   2003 C CB  . LEU B 2 46  ? 5.261   -7.303  31.435  1.00 26.97 ? 46  LEU L CB  1 
ATOM   2004 C CG  . LEU B 2 46  ? 6.318   -7.780  30.443  1.00 30.48 ? 46  LEU L CG  1 
ATOM   2005 C CD1 . LEU B 2 46  ? 5.648   -8.289  29.162  1.00 25.68 ? 46  LEU L CD1 1 
ATOM   2006 C CD2 . LEU B 2 46  ? 7.318   -6.664  30.155  1.00 24.75 ? 46  LEU L CD2 1 
ATOM   2007 N N   . LEU B 2 47  ? 5.118   -10.688 31.847  1.00 23.91 ? 47  LEU L N   1 
ATOM   2008 C CA  . LEU B 2 47  ? 5.942   -11.861 32.131  1.00 29.67 ? 47  LEU L CA  1 
ATOM   2009 C C   . LEU B 2 47  ? 6.975   -12.130 31.048  1.00 31.10 ? 47  LEU L C   1 
ATOM   2010 O O   . LEU B 2 47  ? 8.150   -12.394 31.352  1.00 29.94 ? 47  LEU L O   1 
ATOM   2011 C CB  . LEU B 2 47  ? 5.061   -13.112 32.292  1.00 28.91 ? 47  LEU L CB  1 
ATOM   2012 C CG  . LEU B 2 47  ? 3.996   -13.107 33.385  1.00 26.87 ? 47  LEU L CG  1 
ATOM   2013 C CD1 . LEU B 2 47  ? 3.222   -14.449 33.422  1.00 35.49 ? 47  LEU L CD1 1 
ATOM   2014 C CD2 . LEU B 2 47  ? 4.676   -12.828 34.707  1.00 31.36 ? 47  LEU L CD2 1 
ATOM   2015 N N   . ILE B 2 48  ? 6.555   -12.098 29.786  1.00 27.43 ? 48  ILE L N   1 
ATOM   2016 C CA  . ILE B 2 48  ? 7.390   -12.502 28.658  1.00 29.73 ? 48  ILE L CA  1 
ATOM   2017 C C   . ILE B 2 48  ? 7.105   -11.560 27.494  1.00 30.25 ? 48  ILE L C   1 
ATOM   2018 O O   . ILE B 2 48  ? 5.974   -11.092 27.328  1.00 28.03 ? 48  ILE L O   1 
ATOM   2019 C CB  . ILE B 2 48  ? 7.117   -13.973 28.278  1.00 29.34 ? 48  ILE L CB  1 
ATOM   2020 C CG1 . ILE B 2 48  ? 7.729   -14.918 29.324  1.00 34.40 ? 48  ILE L CG1 1 
ATOM   2021 C CG2 . ILE B 2 48  ? 7.610   -14.300 26.866  1.00 26.56 ? 48  ILE L CG2 1 
ATOM   2022 C CD1 . ILE B 2 48  ? 7.369   -16.393 29.093  1.00 36.49 ? 48  ILE L CD1 1 
ATOM   2023 N N   . TYR B 2 49  ? 8.136   -11.249 26.711  1.00 30.17 ? 49  TYR L N   1 
ATOM   2024 C CA  . TYR B 2 49  ? 7.965   -10.485 25.482  1.00 26.96 ? 49  TYR L CA  1 
ATOM   2025 C C   . TYR B 2 49  ? 8.922   -11.032 24.426  1.00 32.04 ? 49  TYR L C   1 
ATOM   2026 O O   . TYR B 2 49  ? 9.859   -11.778 24.732  1.00 30.80 ? 49  TYR L O   1 
ATOM   2027 C CB  . TYR B 2 49  ? 8.202   -9.001  25.722  1.00 30.07 ? 49  TYR L CB  1 
ATOM   2028 C CG  . TYR B 2 49  ? 9.591   -8.722  26.200  1.00 31.84 ? 49  TYR L CG  1 
ATOM   2029 C CD1 . TYR B 2 49  ? 10.631  -8.512  25.288  1.00 34.65 ? 49  TYR L CD1 1 
ATOM   2030 C CD2 . TYR B 2 49  ? 9.890   -8.693  27.566  1.00 29.16 ? 49  TYR L CD2 1 
ATOM   2031 C CE1 . TYR B 2 49  ? 11.927  -8.270  25.719  1.00 28.22 ? 49  TYR L CE1 1 
ATOM   2032 C CE2 . TYR B 2 49  ? 11.189  -8.451  28.007  1.00 31.08 ? 49  TYR L CE2 1 
ATOM   2033 C CZ  . TYR B 2 49  ? 12.195  -8.231  27.074  1.00 36.54 ? 49  TYR L CZ  1 
ATOM   2034 O OH  . TYR B 2 49  ? 13.475  -7.984  27.493  1.00 46.70 ? 49  TYR L OH  1 
ATOM   2035 N N   . GLY B 2 50  ? 8.683   -10.666 23.168  1.00 27.84 ? 50  GLY L N   1 
ATOM   2036 C CA  . GLY B 2 50  ? 9.454   -11.296 22.116  1.00 32.95 ? 50  GLY L CA  1 
ATOM   2037 C C   . GLY B 2 50  ? 9.179   -12.774 22.036  1.00 34.69 ? 50  GLY L C   1 
ATOM   2038 O O   . GLY B 2 50  ? 10.024  -13.540 21.574  1.00 34.82 ? 50  GLY L O   1 
ATOM   2039 N N   . ALA B 2 51  ? 8.031   -13.190 22.561  1.00 32.85 ? 51  ALA L N   1 
ATOM   2040 C CA  . ALA B 2 51  ? 7.501   -14.549 22.596  1.00 33.58 ? 51  ALA L CA  1 
ATOM   2041 C C   . ALA B 2 51  ? 8.251   -15.487 23.535  1.00 33.11 ? 51  ALA L C   1 
ATOM   2042 O O   . ALA B 2 51  ? 7.639   -16.418 24.065  1.00 31.89 ? 51  ALA L O   1 
ATOM   2043 C CB  . ALA B 2 51  ? 7.510   -15.160 21.193  1.00 28.38 ? 51  ALA L CB  1 
ATOM   2044 N N   . SER B 2 52  ? 9.527   -15.194 23.860  1.00 34.65 ? 52  SER L N   1 
ATOM   2045 C CA  . SER B 2 52  ? 10.317  -16.153 24.631  1.00 31.31 ? 52  SER L CA  1 
ATOM   2046 C C   . SER B 2 52  ? 11.311  -15.527 25.598  1.00 36.59 ? 52  SER L C   1 
ATOM   2047 O O   . SER B 2 52  ? 12.033  -16.273 26.267  1.00 38.24 ? 52  SER L O   1 
ATOM   2048 C CB  . SER B 2 52  ? 11.067  -17.099 23.677  1.00 35.64 ? 52  SER L CB  1 
ATOM   2049 O OG  . SER B 2 52  ? 12.002  -16.375 22.902  1.00 35.41 ? 52  SER L OG  1 
ATOM   2050 N N   . THR B 2 53  ? 11.379  -14.208 25.706  1.00 31.59 ? 53  THR L N   1 
ATOM   2051 C CA  . THR B 2 53  ? 12.289  -13.548 26.630  1.00 30.68 ? 53  THR L CA  1 
ATOM   2052 C C   . THR B 2 53  ? 11.563  -13.298 27.945  1.00 32.50 ? 53  THR L C   1 
ATOM   2053 O O   . THR B 2 53  ? 10.574  -12.559 27.977  1.00 27.86 ? 53  THR L O   1 
ATOM   2054 C CB  . THR B 2 53  ? 12.781  -12.234 26.026  1.00 25.20 ? 53  THR L CB  1 
ATOM   2055 O OG1 . THR B 2 53  ? 13.399  -12.508 24.761  1.00 29.17 ? 53  THR L OG1 1 
ATOM   2056 C CG2 . THR B 2 53  ? 13.769  -11.543 26.940  1.00 29.26 ? 53  THR L CG2 1 
ATOM   2057 N N   . LEU B 2 54  ? 12.045  -13.915 29.022  1.00 32.21 ? 54  LEU L N   1 
ATOM   2058 C CA  . LEU B 2 54  ? 11.505  -13.618 30.343  1.00 35.55 ? 54  LEU L CA  1 
ATOM   2059 C C   . LEU B 2 54  ? 11.798  -12.175 30.727  1.00 32.01 ? 54  LEU L C   1 
ATOM   2060 O O   . LEU B 2 54  ? 12.884  -11.659 30.470  1.00 32.90 ? 54  LEU L O   1 
ATOM   2061 C CB  . LEU B 2 54  ? 12.112  -14.545 31.394  1.00 35.51 ? 54  LEU L CB  1 
ATOM   2062 C CG  . LEU B 2 54  ? 11.216  -15.630 31.964  1.00 37.93 ? 54  LEU L CG  1 
ATOM   2063 C CD1 . LEU B 2 54  ? 10.888  -16.611 30.866  1.00 37.94 ? 54  LEU L CD1 1 
ATOM   2064 C CD2 . LEU B 2 54  ? 11.919  -16.309 33.140  1.00 37.98 ? 54  LEU L CD2 1 
ATOM   2065 N N   . GLN B 2 55  ? 10.813  -11.518 31.327  1.00 32.13 ? 55  GLN L N   1 
ATOM   2066 C CA  . GLN B 2 55  ? 11.085  -10.268 32.019  1.00 31.60 ? 55  GLN L CA  1 
ATOM   2067 C C   . GLN B 2 55  ? 11.933  -10.544 33.260  1.00 36.94 ? 55  GLN L C   1 
ATOM   2068 O O   . GLN B 2 55  ? 11.796  -11.585 33.910  1.00 34.42 ? 55  GLN L O   1 
ATOM   2069 C CB  . GLN B 2 55  ? 9.775   -9.585  32.398  1.00 31.22 ? 55  GLN L CB  1 
ATOM   2070 C CG  . GLN B 2 55  ? 9.920   -8.304  33.194  1.00 32.31 ? 55  GLN L CG  1 
ATOM   2071 C CD  . GLN B 2 55  ? 10.440  -7.151  32.368  1.00 34.00 ? 55  GLN L CD  1 
ATOM   2072 O OE1 . GLN B 2 55  ? 11.082  -7.345  31.337  1.00 38.46 ? 55  GLN L OE1 1 
ATOM   2073 N NE2 . GLN B 2 55  ? 10.160  -5.940  32.811  1.00 36.35 ? 55  GLN L NE2 1 
ATOM   2074 N N   . SER B 2 56  ? 12.822  -9.601  33.579  1.00 37.27 ? 56  SER L N   1 
ATOM   2075 C CA  . SER B 2 56  ? 13.790  -9.803  34.650  1.00 39.15 ? 56  SER L CA  1 
ATOM   2076 C C   . SER B 2 56  ? 13.090  -10.066 35.980  1.00 37.31 ? 56  SER L C   1 
ATOM   2077 O O   . SER B 2 56  ? 12.145  -9.363  36.360  1.00 37.60 ? 56  SER L O   1 
ATOM   2078 C CB  . SER B 2 56  ? 14.713  -8.588  34.767  1.00 43.56 ? 56  SER L CB  1 
ATOM   2079 O OG  . SER B 2 56  ? 15.568  -8.497  33.636  1.00 50.76 ? 56  SER L OG  1 
ATOM   2080 N N   . GLY B 2 57  ? 13.551  -11.104 36.681  1.00 37.60 ? 57  GLY L N   1 
ATOM   2081 C CA  . GLY B 2 57  ? 12.975  -11.487 37.949  1.00 37.39 ? 57  GLY L CA  1 
ATOM   2082 C C   . GLY B 2 57  ? 11.748  -12.368 37.861  1.00 36.78 ? 57  GLY L C   1 
ATOM   2083 O O   . GLY B 2 57  ? 11.258  -12.820 38.903  1.00 34.82 ? 57  GLY L O   1 
ATOM   2084 N N   . VAL B 2 58  ? 11.223  -12.623 36.669  1.00 37.16 ? 58  VAL L N   1 
ATOM   2085 C CA  . VAL B 2 58  ? 10.167  -13.638 36.542  1.00 38.44 ? 58  VAL L CA  1 
ATOM   2086 C C   . VAL B 2 58  ? 10.767  -15.015 36.823  1.00 34.22 ? 58  VAL L C   1 
ATOM   2087 O O   . VAL B 2 58  ? 11.848  -15.337 36.299  1.00 32.15 ? 58  VAL L O   1 
ATOM   2088 C CB  . VAL B 2 58  ? 9.526   -13.582 35.145  1.00 36.02 ? 58  VAL L CB  1 
ATOM   2089 C CG1 . VAL B 2 58  ? 8.543   -14.728 34.964  1.00 34.69 ? 58  VAL L CG1 1 
ATOM   2090 C CG2 . VAL B 2 58  ? 8.799   -12.255 34.950  1.00 33.59 ? 58  VAL L CG2 1 
ATOM   2091 N N   . PRO B 2 59  ? 10.131  -15.839 37.653  1.00 37.16 ? 59  PRO L N   1 
ATOM   2092 C CA  . PRO B 2 59  ? 10.725  -17.138 38.000  1.00 34.02 ? 59  PRO L CA  1 
ATOM   2093 C C   . PRO B 2 59  ? 10.856  -18.076 36.809  1.00 34.89 ? 59  PRO L C   1 
ATOM   2094 O O   . PRO B 2 59  ? 10.116  -18.000 35.824  1.00 34.41 ? 59  PRO L O   1 
ATOM   2095 C CB  . PRO B 2 59  ? 9.765   -17.704 39.056  1.00 32.83 ? 59  PRO L CB  1 
ATOM   2096 C CG  . PRO B 2 59  ? 8.580   -16.769 39.072  1.00 33.48 ? 59  PRO L CG  1 
ATOM   2097 C CD  . PRO B 2 59  ? 9.066   -15.455 38.586  1.00 32.64 ? 59  PRO L CD  1 
ATOM   2098 N N   . SER B 2 60  ? 11.829  -18.976 36.926  1.00 34.43 ? 60  SER L N   1 
ATOM   2099 C CA  . SER B 2 60  ? 12.230  -19.853 35.832  1.00 38.20 ? 60  SER L CA  1 
ATOM   2100 C C   . SER B 2 60  ? 11.138  -20.820 35.389  1.00 34.53 ? 60  SER L C   1 
ATOM   2101 O O   . SER B 2 60  ? 11.221  -21.342 34.273  1.00 34.44 ? 60  SER L O   1 
ATOM   2102 C CB  . SER B 2 60  ? 13.473  -20.643 36.244  1.00 39.36 ? 60  SER L CB  1 
ATOM   2103 O OG  . SER B 2 60  ? 13.541  -21.864 35.546  1.00 49.25 ? 60  SER L OG  1 
ATOM   2104 N N   . ARG B 2 61  ? 10.115  -21.074 36.212  1.00 29.69 ? 61  ARG L N   1 
ATOM   2105 C CA  . ARG B 2 61  ? 9.059   -21.991 35.769  1.00 32.42 ? 61  ARG L CA  1 
ATOM   2106 C C   . ARG B 2 61  ? 8.290   -21.475 34.550  1.00 34.50 ? 61  ARG L C   1 
ATOM   2107 O O   . ARG B 2 61  ? 7.571   -22.256 33.911  1.00 34.03 ? 61  ARG L O   1 
ATOM   2108 C CB  . ARG B 2 61  ? 8.075   -22.292 36.905  1.00 29.13 ? 61  ARG L CB  1 
ATOM   2109 C CG  . ARG B 2 61  ? 7.299   -21.096 37.423  1.00 32.91 ? 61  ARG L CG  1 
ATOM   2110 C CD  . ARG B 2 61  ? 6.508   -21.499 38.651  1.00 30.86 ? 61  ARG L CD  1 
ATOM   2111 N NE  . ARG B 2 61  ? 5.823   -20.377 39.273  1.00 31.35 ? 61  ARG L NE  1 
ATOM   2112 C CZ  . ARG B 2 61  ? 6.382   -19.557 40.148  1.00 33.55 ? 61  ARG L CZ  1 
ATOM   2113 N NH1 . ARG B 2 61  ? 7.651   -19.681 40.493  1.00 34.00 ? 61  ARG L NH1 1 
ATOM   2114 N NH2 . ARG B 2 61  ? 5.648   -18.591 40.695  1.00 33.43 ? 61  ARG L NH2 1 
ATOM   2115 N N   . PHE B 2 62  ? 8.416   -20.189 34.212  1.00 29.45 ? 62  PHE L N   1 
ATOM   2116 C CA  . PHE B 2 62  ? 7.725   -19.618 33.056  1.00 32.90 ? 62  PHE L CA  1 
ATOM   2117 C C   . PHE B 2 62  ? 8.626   -19.639 31.837  1.00 33.47 ? 62  PHE L C   1 
ATOM   2118 O O   . PHE B 2 62  ? 9.782   -19.213 31.907  1.00 34.15 ? 62  PHE L O   1 
ATOM   2119 C CB  . PHE B 2 62  ? 7.305   -18.173 33.313  1.00 30.61 ? 62  PHE L CB  1 
ATOM   2120 C CG  . PHE B 2 62  ? 6.311   -18.020 34.416  1.00 28.66 ? 62  PHE L CG  1 
ATOM   2121 C CD1 . PHE B 2 62  ? 4.956   -18.106 34.156  1.00 30.75 ? 62  PHE L CD1 1 
ATOM   2122 C CD2 . PHE B 2 62  ? 6.732   -17.765 35.717  1.00 34.70 ? 62  PHE L CD2 1 
ATOM   2123 C CE1 . PHE B 2 62  ? 4.032   -17.953 35.174  1.00 28.27 ? 62  PHE L CE1 1 
ATOM   2124 C CE2 . PHE B 2 62  ? 5.811   -17.619 36.749  1.00 32.50 ? 62  PHE L CE2 1 
ATOM   2125 C CZ  . PHE B 2 62  ? 4.462   -17.715 36.476  1.00 31.60 ? 62  PHE L CZ  1 
ATOM   2126 N N   . SER B 2 63  ? 8.084   -20.092 30.712  1.00 30.04 ? 63  SER L N   1 
ATOM   2127 C CA  . SER B 2 63  ? 8.807   -19.957 29.465  1.00 33.43 ? 63  SER L CA  1 
ATOM   2128 C C   . SER B 2 63  ? 7.800   -19.797 28.339  1.00 34.66 ? 63  SER L C   1 
ATOM   2129 O O   . SER B 2 63  ? 6.651   -20.238 28.435  1.00 31.19 ? 63  SER L O   1 
ATOM   2130 C CB  . SER B 2 63  ? 9.727   -21.160 29.222  1.00 35.29 ? 63  SER L CB  1 
ATOM   2131 O OG  . SER B 2 63  ? 8.966   -22.356 29.197  1.00 34.25 ? 63  SER L OG  1 
ATOM   2132 N N   . GLY B 2 64  ? 8.246   -19.156 27.272  1.00 38.78 ? 64  GLY L N   1 
ATOM   2133 C CA  . GLY B 2 64  ? 7.424   -18.997 26.087  1.00 38.06 ? 64  GLY L CA  1 
ATOM   2134 C C   . GLY B 2 64  ? 8.196   -19.461 24.873  1.00 31.05 ? 64  GLY L C   1 
ATOM   2135 O O   . GLY B 2 64  ? 9.420   -19.417 24.843  1.00 33.34 ? 64  GLY L O   1 
ATOM   2136 N N   . SER B 2 65  ? 7.461   -19.940 23.875  1.00 29.99 ? 65  SER L N   1 
ATOM   2137 C CA  . SER B 2 65  ? 8.085   -20.395 22.640  1.00 37.56 ? 65  SER L CA  1 
ATOM   2138 C C   . SER B 2 65  ? 7.075   -20.302 21.504  1.00 35.39 ? 65  SER L C   1 
ATOM   2139 O O   . SER B 2 65  ? 5.907   -19.960 21.706  1.00 39.26 ? 65  SER L O   1 
ATOM   2140 C CB  . SER B 2 65  ? 8.594   -21.829 22.773  1.00 40.22 ? 65  SER L CB  1 
ATOM   2141 O OG  . SER B 2 65  ? 7.490   -22.707 22.799  1.00 38.82 ? 65  SER L OG  1 
ATOM   2142 N N   . GLY B 2 66  ? 7.534   -20.629 20.304  1.00 37.36 ? 66  GLY L N   1 
ATOM   2143 C CA  . GLY B 2 66  ? 6.699   -20.575 19.126  1.00 35.93 ? 66  GLY L CA  1 
ATOM   2144 C C   . GLY B 2 66  ? 7.210   -19.542 18.150  1.00 38.93 ? 66  GLY L C   1 
ATOM   2145 O O   . GLY B 2 66  ? 7.858   -18.574 18.553  1.00 51.17 ? 66  GLY L O   1 
ATOM   2146 N N   . SER B 2 67  ? 6.949   -19.742 16.863  1.00 39.65 ? 67  SER L N   1 
ATOM   2147 C CA  . SER B 2 67  ? 7.197   -18.701 15.877  1.00 46.43 ? 67  SER L CA  1 
ATOM   2148 C C   . SER B 2 67  ? 6.235   -18.888 14.716  1.00 44.55 ? 67  SER L C   1 
ATOM   2149 O O   . SER B 2 67  ? 5.630   -19.951 14.542  1.00 49.59 ? 67  SER L O   1 
ATOM   2150 C CB  . SER B 2 67  ? 8.646   -18.690 15.385  1.00 51.80 ? 67  SER L CB  1 
ATOM   2151 O OG  . SER B 2 67  ? 9.465   -17.966 16.288  1.00 56.80 ? 67  SER L OG  1 
ATOM   2152 N N   . GLY B 2 68  ? 6.079   -17.823 13.942  1.00 50.69 ? 68  GLY L N   1 
ATOM   2153 C CA  . GLY B 2 68  ? 5.086   -17.821 12.896  1.00 45.42 ? 68  GLY L CA  1 
ATOM   2154 C C   . GLY B 2 68  ? 3.741   -17.432 13.463  1.00 41.18 ? 68  GLY L C   1 
ATOM   2155 O O   . GLY B 2 68  ? 3.487   -16.251 13.714  1.00 42.09 ? 68  GLY L O   1 
ATOM   2156 N N   . THR B 2 69  ? 2.878   -18.420 13.690  1.00 38.65 ? 69  THR L N   1 
ATOM   2157 C CA  . THR B 2 69  ? 1.506   -18.166 14.090  1.00 37.64 ? 69  THR L CA  1 
ATOM   2158 C C   . THR B 2 69  ? 1.092   -18.810 15.409  1.00 37.98 ? 69  THR L C   1 
ATOM   2159 O O   . THR B 2 69  ? 0.003   -18.491 15.910  1.00 35.94 ? 69  THR L O   1 
ATOM   2160 C CB  . THR B 2 69  ? 0.547   -18.659 13.005  1.00 36.41 ? 69  THR L CB  1 
ATOM   2161 O OG1 . THR B 2 69  ? 0.719   -20.067 12.872  1.00 43.90 ? 69  THR L OG1 1 
ATOM   2162 C CG2 . THR B 2 69  ? 0.836   -17.980 11.663  1.00 38.22 ? 69  THR L CG2 1 
ATOM   2163 N N   . ASP B 2 70  ? 1.899   -19.713 15.965  1.00 32.62 ? 70  ASP L N   1 
ATOM   2164 C CA  . ASP B 2 70  ? 1.524   -20.550 17.104  1.00 32.28 ? 70  ASP L CA  1 
ATOM   2165 C C   . ASP B 2 70  ? 2.500   -20.289 18.241  1.00 34.43 ? 70  ASP L C   1 
ATOM   2166 O O   . ASP B 2 70  ? 3.713   -20.438 18.064  1.00 33.99 ? 70  ASP L O   1 
ATOM   2167 C CB  . ASP B 2 70  ? 1.544   -22.034 16.730  1.00 38.13 ? 70  ASP L CB  1 
ATOM   2168 C CG  . ASP B 2 70  ? 0.415   -22.420 15.783  1.00 49.02 ? 70  ASP L CG  1 
ATOM   2169 O OD1 . ASP B 2 70  ? -0.408  -21.544 15.433  1.00 49.62 ? 70  ASP L OD1 1 
ATOM   2170 O OD2 . ASP B 2 70  ? 0.337   -23.608 15.396  1.00 51.86 ? 70  ASP L OD2 1 
ATOM   2171 N N   . PHE B 2 71  ? 1.980   -19.914 19.404  1.00 33.75 ? 71  PHE L N   1 
ATOM   2172 C CA  . PHE B 2 71  ? 2.832   -19.540 20.523  1.00 33.57 ? 71  PHE L CA  1 
ATOM   2173 C C   . PHE B 2 71  ? 2.311   -20.166 21.798  1.00 32.88 ? 71  PHE L C   1 
ATOM   2174 O O   . PHE B 2 71  ? 1.106   -20.336 21.975  1.00 33.50 ? 71  PHE L O   1 
ATOM   2175 C CB  . PHE B 2 71  ? 2.911   -18.028 20.681  1.00 31.56 ? 71  PHE L CB  1 
ATOM   2176 C CG  . PHE B 2 71  ? 3.479   -17.359 19.483  1.00 37.62 ? 71  PHE L CG  1 
ATOM   2177 C CD1 . PHE B 2 71  ? 2.661   -16.993 18.430  1.00 36.03 ? 71  PHE L CD1 1 
ATOM   2178 C CD2 . PHE B 2 71  ? 4.838   -17.140 19.385  1.00 34.79 ? 71  PHE L CD2 1 
ATOM   2179 C CE1 . PHE B 2 71  ? 3.197   -16.410 17.304  1.00 38.66 ? 71  PHE L CE1 1 
ATOM   2180 C CE2 . PHE B 2 71  ? 5.374   -16.546 18.265  1.00 38.38 ? 71  PHE L CE2 1 
ATOM   2181 C CZ  . PHE B 2 71  ? 4.557   -16.183 17.228  1.00 36.11 ? 71  PHE L CZ  1 
ATOM   2182 N N   . THR B 2 72  ? 3.237   -20.485 22.696  1.00 36.94 ? 72  THR L N   1 
ATOM   2183 C CA  . THR B 2 72  ? 2.895   -21.213 23.904  1.00 33.97 ? 72  THR L CA  1 
ATOM   2184 C C   . THR B 2 72  ? 3.526   -20.543 25.106  1.00 33.03 ? 72  THR L C   1 
ATOM   2185 O O   . THR B 2 72  ? 4.722   -20.242 25.096  1.00 32.34 ? 72  THR L O   1 
ATOM   2186 C CB  . THR B 2 72  ? 3.358   -22.669 23.809  1.00 32.42 ? 72  THR L CB  1 
ATOM   2187 O OG1 . THR B 2 72  ? 2.540   -23.353 22.857  1.00 33.80 ? 72  THR L OG1 1 
ATOM   2188 C CG2 . THR B 2 72  ? 3.219   -23.348 25.165  1.00 39.77 ? 72  THR L CG2 1 
ATOM   2189 N N   . LEU B 2 73  ? 2.721   -20.313 26.134  1.00 32.04 ? 73  LEU L N   1 
ATOM   2190 C CA  . LEU B 2 73  ? 3.222   -20.005 27.467  1.00 31.95 ? 73  LEU L CA  1 
ATOM   2191 C C   . LEU B 2 73  ? 3.190   -21.295 28.278  1.00 32.83 ? 73  LEU L C   1 
ATOM   2192 O O   . LEU B 2 73  ? 2.148   -21.962 28.350  1.00 32.42 ? 73  LEU L O   1 
ATOM   2193 C CB  . LEU B 2 73  ? 2.368   -18.922 28.131  1.00 32.90 ? 73  LEU L CB  1 
ATOM   2194 C CG  . LEU B 2 73  ? 2.546   -18.716 29.636  1.00 33.08 ? 73  LEU L CG  1 
ATOM   2195 C CD1 . LEU B 2 73  ? 3.958   -18.291 29.951  1.00 27.97 ? 73  LEU L CD1 1 
ATOM   2196 C CD2 . LEU B 2 73  ? 1.517   -17.730 30.233  1.00 29.72 ? 73  LEU L CD2 1 
ATOM   2197 N N   . THR B 2 74  ? 4.328   -21.678 28.848  1.00 27.14 ? 74  THR L N   1 
ATOM   2198 C CA  . THR B 2 74  ? 4.382   -22.892 29.651  1.00 33.15 ? 74  THR L CA  1 
ATOM   2199 C C   . THR B 2 74  ? 4.794   -22.558 31.073  1.00 33.48 ? 74  THR L C   1 
ATOM   2200 O O   . THR B 2 74  ? 5.789   -21.856 31.287  1.00 31.86 ? 74  THR L O   1 
ATOM   2201 C CB  . THR B 2 74  ? 5.333   -23.924 29.038  1.00 33.25 ? 74  THR L CB  1 
ATOM   2202 O OG1 . THR B 2 74  ? 4.798   -24.331 27.773  1.00 33.00 ? 74  THR L OG1 1 
ATOM   2203 C CG2 . THR B 2 74  ? 5.455   -25.155 29.957  1.00 35.24 ? 74  THR L CG2 1 
ATOM   2204 N N   . ILE B 2 75  ? 4.011   -23.049 32.039  1.00 32.55 ? 75  ILE L N   1 
ATOM   2205 C CA  . ILE B 2 75  ? 4.367   -22.994 33.451  1.00 32.31 ? 75  ILE L CA  1 
ATOM   2206 C C   . ILE B 2 75  ? 4.732   -24.412 33.854  1.00 32.73 ? 75  ILE L C   1 
ATOM   2207 O O   . ILE B 2 75  ? 3.867   -25.297 33.904  1.00 34.21 ? 75  ILE L O   1 
ATOM   2208 C CB  . ILE B 2 75  ? 3.234   -22.432 34.321  1.00 31.58 ? 75  ILE L CB  1 
ATOM   2209 C CG1 . ILE B 2 75  ? 2.723   -21.117 33.743  1.00 29.39 ? 75  ILE L CG1 1 
ATOM   2210 C CG2 . ILE B 2 75  ? 3.755   -22.189 35.736  1.00 32.51 ? 75  ILE L CG2 1 
ATOM   2211 C CD1 . ILE B 2 75  ? 1.471   -20.565 34.421  1.00 29.08 ? 75  ILE L CD1 1 
ATOM   2212 N N   . SER B 2 76  ? 6.017   -24.632 34.122  1.00 33.91 ? 76  SER L N   1 
ATOM   2213 C CA  . SER B 2 76  ? 6.511   -25.999 34.229  1.00 38.66 ? 76  SER L CA  1 
ATOM   2214 C C   . SER B 2 76  ? 6.031   -26.666 35.515  1.00 41.12 ? 76  SER L C   1 
ATOM   2215 O O   . SER B 2 76  ? 5.739   -27.868 35.521  1.00 45.50 ? 76  SER L O   1 
ATOM   2216 C CB  . SER B 2 76  ? 8.034   -26.015 34.129  1.00 35.25 ? 76  SER L CB  1 
ATOM   2217 O OG  . SER B 2 76  ? 8.631   -25.224 35.148  1.00 42.18 ? 76  SER L OG  1 
ATOM   2218 N N   . SER B 2 77  ? 5.925   -25.910 36.609  1.00 33.51 ? 77  SER L N   1 
ATOM   2219 C CA  . SER B 2 77  ? 5.390   -26.476 37.849  1.00 37.84 ? 77  SER L CA  1 
ATOM   2220 C C   . SER B 2 77  ? 4.636   -25.389 38.611  1.00 38.77 ? 77  SER L C   1 
ATOM   2221 O O   . SER B 2 77  ? 5.254   -24.507 39.223  1.00 35.60 ? 77  SER L O   1 
ATOM   2222 C CB  . SER B 2 77  ? 6.501   -27.071 38.702  1.00 34.23 ? 77  SER L CB  1 
ATOM   2223 O OG  . SER B 2 77  ? 6.054   -27.257 40.033  1.00 44.46 ? 77  SER L OG  1 
ATOM   2224 N N   . LEU B 2 78  ? 3.307   -25.474 38.603  1.00 35.99 ? 78  LEU L N   1 
ATOM   2225 C CA  . LEU B 2 78  ? 2.486   -24.415 39.176  1.00 39.20 ? 78  LEU L CA  1 
ATOM   2226 C C   . LEU B 2 78  ? 2.765   -24.230 40.662  1.00 42.77 ? 78  LEU L C   1 
ATOM   2227 O O   . LEU B 2 78  ? 2.740   -25.189 41.437  1.00 42.49 ? 78  LEU L O   1 
ATOM   2228 C CB  . LEU B 2 78  ? 1.009   -24.733 38.970  1.00 38.55 ? 78  LEU L CB  1 
ATOM   2229 C CG  . LEU B 2 78  ? 0.381   -24.394 37.627  1.00 38.37 ? 78  LEU L CG  1 
ATOM   2230 C CD1 . LEU B 2 78  ? -0.968  -25.080 37.542  1.00 38.29 ? 78  LEU L CD1 1 
ATOM   2231 C CD2 . LEU B 2 78  ? 0.227   -22.893 37.493  1.00 33.38 ? 78  LEU L CD2 1 
ATOM   2232 N N   . GLN B 2 79  ? 3.021   -22.997 41.050  1.00 36.77 ? 79  GLN L N   1 
ATOM   2233 C CA  . GLN B 2 79  ? 2.997   -22.557 42.431  1.00 37.44 ? 79  GLN L CA  1 
ATOM   2234 C C   . GLN B 2 79  ? 1.621   -21.971 42.764  1.00 38.67 ? 79  GLN L C   1 
ATOM   2235 O O   . GLN B 2 79  ? 0.824   -21.676 41.864  1.00 38.27 ? 79  GLN L O   1 
ATOM   2236 C CB  . GLN B 2 79  ? 4.102   -21.529 42.660  1.00 35.53 ? 79  GLN L CB  1 
ATOM   2237 C CG  . GLN B 2 79  ? 5.498   -22.096 42.496  1.00 39.41 ? 79  GLN L CG  1 
ATOM   2238 C CD  . GLN B 2 79  ? 5.941   -22.922 43.697  1.00 46.31 ? 79  GLN L CD  1 
ATOM   2239 O OE1 . GLN B 2 79  ? 5.656   -22.575 44.845  1.00 46.50 ? 79  GLN L OE1 1 
ATOM   2240 N NE2 . GLN B 2 79  ? 6.654   -24.013 43.435  1.00 45.68 ? 79  GLN L NE2 1 
ATOM   2241 N N   . PRO B 2 80  ? 1.272   -21.840 44.048  1.00 40.36 ? 80  PRO L N   1 
ATOM   2242 C CA  . PRO B 2 80  ? -0.060  -21.296 44.375  1.00 40.39 ? 80  PRO L CA  1 
ATOM   2243 C C   . PRO B 2 80  ? -0.266  -19.872 43.874  1.00 38.12 ? 80  PRO L C   1 
ATOM   2244 O O   . PRO B 2 80  ? -1.383  -19.520 43.485  1.00 41.36 ? 80  PRO L O   1 
ATOM   2245 C CB  . PRO B 2 80  ? -0.103  -21.365 45.910  1.00 39.79 ? 80  PRO L CB  1 
ATOM   2246 C CG  . PRO B 2 80  ? 0.970   -22.338 46.292  1.00 38.17 ? 80  PRO L CG  1 
ATOM   2247 C CD  . PRO B 2 80  ? 2.042   -22.155 45.266  1.00 42.50 ? 80  PRO L CD  1 
ATOM   2248 N N   . GLU B 2 81  ? 0.784   -19.046 43.857  1.00 38.83 ? 81  GLU L N   1 
ATOM   2249 C CA  . GLU B 2 81  ? 0.673   -17.674 43.374  1.00 39.81 ? 81  GLU L CA  1 
ATOM   2250 C C   . GLU B 2 81  ? 0.407   -17.586 41.875  1.00 41.01 ? 81  GLU L C   1 
ATOM   2251 O O   . GLU B 2 81  ? 0.109   -16.490 41.389  1.00 40.98 ? 81  GLU L O   1 
ATOM   2252 C CB  . GLU B 2 81  ? 1.938   -16.884 43.725  1.00 36.91 ? 81  GLU L CB  1 
ATOM   2253 C CG  . GLU B 2 81  ? 3.256   -17.659 43.631  1.00 46.61 ? 81  GLU L CG  1 
ATOM   2254 C CD  . GLU B 2 81  ? 3.526   -18.565 44.847  1.00 52.55 ? 81  GLU L CD  1 
ATOM   2255 O OE1 . GLU B 2 81  ? 2.576   -18.850 45.617  1.00 48.32 ? 81  GLU L OE1 1 
ATOM   2256 O OE2 . GLU B 2 81  ? 4.692   -19.003 45.034  1.00 56.28 ? 81  GLU L OE2 1 
ATOM   2257 N N   . ASP B 2 82  ? 0.514   -18.695 41.131  1.00 35.02 ? 82  ASP L N   1 
ATOM   2258 C CA  . ASP B 2 82  ? 0.330   -18.683 39.684  1.00 34.95 ? 82  ASP L CA  1 
ATOM   2259 C C   . ASP B 2 82  ? -1.121  -18.839 39.249  1.00 35.37 ? 82  ASP L C   1 
ATOM   2260 O O   . ASP B 2 82  ? -1.417  -18.698 38.054  1.00 30.93 ? 82  ASP L O   1 
ATOM   2261 C CB  . ASP B 2 82  ? 1.134   -19.801 39.032  1.00 33.97 ? 82  ASP L CB  1 
ATOM   2262 C CG  . ASP B 2 82  ? 2.588   -19.741 39.388  1.00 37.80 ? 82  ASP L CG  1 
ATOM   2263 O OD1 . ASP B 2 82  ? 3.024   -18.667 39.862  1.00 31.40 ? 82  ASP L OD1 1 
ATOM   2264 O OD2 . ASP B 2 82  ? 3.280   -20.762 39.188  1.00 36.24 ? 82  ASP L OD2 1 
ATOM   2265 N N   . PHE B 2 83  ? -2.030  -19.149 40.152  1.00 31.02 ? 83  PHE L N   1 
ATOM   2266 C CA  . PHE B 2 83  ? -3.413  -19.299 39.728  1.00 35.47 ? 83  PHE L CA  1 
ATOM   2267 C C   . PHE B 2 83  ? -3.990  -17.904 39.527  1.00 36.46 ? 83  PHE L C   1 
ATOM   2268 O O   . PHE B 2 83  ? -4.071  -17.115 40.476  1.00 43.56 ? 83  PHE L O   1 
ATOM   2269 C CB  . PHE B 2 83  ? -4.186  -20.142 40.739  1.00 39.44 ? 83  PHE L CB  1 
ATOM   2270 C CG  . PHE B 2 83  ? -3.658  -21.560 40.852  1.00 34.55 ? 83  PHE L CG  1 
ATOM   2271 C CD1 . PHE B 2 83  ? -4.150  -22.563 40.031  1.00 35.50 ? 83  PHE L CD1 1 
ATOM   2272 C CD2 . PHE B 2 83  ? -2.633  -21.870 41.740  1.00 42.59 ? 83  PHE L CD2 1 
ATOM   2273 C CE1 . PHE B 2 83  ? -3.662  -23.859 40.118  1.00 39.46 ? 83  PHE L CE1 1 
ATOM   2274 C CE2 . PHE B 2 83  ? -2.131  -23.163 41.833  1.00 36.55 ? 83  PHE L CE2 1 
ATOM   2275 C CZ  . PHE B 2 83  ? -2.649  -24.162 41.022  1.00 39.16 ? 83  PHE L CZ  1 
ATOM   2276 N N   . ALA B 2 84  ? -4.303  -17.584 38.268  1.00 28.51 ? 84  ALA L N   1 
ATOM   2277 C CA  . ALA B 2 84  ? -4.517  -16.220 37.793  1.00 32.22 ? 84  ALA L CA  1 
ATOM   2278 C C   . ALA B 2 84  ? -4.908  -16.269 36.319  1.00 33.68 ? 84  ALA L C   1 
ATOM   2279 O O   . ALA B 2 84  ? -4.981  -17.353 35.729  1.00 32.53 ? 84  ALA L O   1 
ATOM   2280 C CB  . ALA B 2 84  ? -3.260  -15.362 37.978  1.00 30.36 ? 84  ALA L CB  1 
ATOM   2281 N N   . THR B 2 85  ? -5.158  -15.116 35.706  1.00 30.38 ? 85  THR L N   1 
ATOM   2282 C CA  . THR B 2 85  ? -5.516  -15.079 34.295  1.00 31.88 ? 85  THR L CA  1 
ATOM   2283 C C   . THR B 2 85  ? -4.305  -14.630 33.500  1.00 28.58 ? 85  THR L C   1 
ATOM   2284 O O   . THR B 2 85  ? -3.517  -13.796 33.961  1.00 26.83 ? 85  THR L O   1 
ATOM   2285 C CB  . THR B 2 85  ? -6.708  -14.147 34.032  1.00 28.67 ? 85  THR L CB  1 
ATOM   2286 O OG1 . THR B 2 85  ? -7.797  -14.562 34.848  1.00 29.36 ? 85  THR L OG1 1 
ATOM   2287 C CG2 . THR B 2 85  ? -7.151  -14.141 32.531  1.00 23.55 ? 85  THR L CG2 1 
ATOM   2288 N N   . TYR B 2 86  ? -4.157  -15.208 32.315  1.00 26.66 ? 86  TYR L N   1 
ATOM   2289 C CA  . TYR B 2 86  ? -3.043  -14.939 31.419  1.00 26.26 ? 86  TYR L CA  1 
ATOM   2290 C C   . TYR B 2 86  ? -3.590  -14.466 30.082  1.00 26.59 ? 86  TYR L C   1 
ATOM   2291 O O   . TYR B 2 86  ? -4.610  -14.976 29.599  1.00 28.90 ? 86  TYR L O   1 
ATOM   2292 C CB  . TYR B 2 86  ? -2.172  -16.193 31.250  1.00 27.59 ? 86  TYR L CB  1 
ATOM   2293 C CG  . TYR B 2 86  ? -1.566  -16.620 32.575  1.00 27.90 ? 86  TYR L CG  1 
ATOM   2294 C CD1 . TYR B 2 86  ? -2.258  -17.470 33.454  1.00 29.93 ? 86  TYR L CD1 1 
ATOM   2295 C CD2 . TYR B 2 86  ? -0.322  -16.138 32.966  1.00 26.75 ? 86  TYR L CD2 1 
ATOM   2296 C CE1 . TYR B 2 86  ? -1.692  -17.841 34.701  1.00 25.93 ? 86  TYR L CE1 1 
ATOM   2297 C CE2 . TYR B 2 86  ? 0.254   -16.500 34.179  1.00 29.90 ? 86  TYR L CE2 1 
ATOM   2298 C CZ  . TYR B 2 86  ? -0.427  -17.345 35.044  1.00 35.19 ? 86  TYR L CZ  1 
ATOM   2299 O OH  . TYR B 2 86  ? 0.186   -17.673 36.240  1.00 29.07 ? 86  TYR L OH  1 
ATOM   2300 N N   . TYR B 2 87  ? -2.936  -13.453 29.521  1.00 26.98 ? 87  TYR L N   1 
ATOM   2301 C CA  . TYR B 2 87  ? -3.304  -12.873 28.237  1.00 27.74 ? 87  TYR L CA  1 
ATOM   2302 C C   . TYR B 2 87  ? -2.080  -12.863 27.342  1.00 24.89 ? 87  TYR L C   1 
ATOM   2303 O O   . TYR B 2 87  ? -1.005  -12.443 27.773  1.00 24.38 ? 87  TYR L O   1 
ATOM   2304 C CB  . TYR B 2 87  ? -3.823  -11.430 28.384  1.00 21.25 ? 87  TYR L CB  1 
ATOM   2305 C CG  . TYR B 2 87  ? -5.110  -11.278 29.164  1.00 25.06 ? 87  TYR L CG  1 
ATOM   2306 C CD1 . TYR B 2 87  ? -6.352  -11.377 28.529  1.00 25.23 ? 87  TYR L CD1 1 
ATOM   2307 C CD2 . TYR B 2 87  ? -5.085  -10.998 30.530  1.00 24.16 ? 87  TYR L CD2 1 
ATOM   2308 C CE1 . TYR B 2 87  ? -7.534  -11.228 29.237  1.00 23.45 ? 87  TYR L CE1 1 
ATOM   2309 C CE2 . TYR B 2 87  ? -6.259  -10.847 31.253  1.00 23.09 ? 87  TYR L CE2 1 
ATOM   2310 C CZ  . TYR B 2 87  ? -7.472  -10.953 30.596  1.00 28.54 ? 87  TYR L CZ  1 
ATOM   2311 O OH  . TYR B 2 87  ? -8.617  -10.802 31.315  1.00 27.92 ? 87  TYR L OH  1 
ATOM   2312 N N   . CYS B 2 88  ? -2.236  -13.297 26.102  1.00 28.08 ? 88  CYS L N   1 
ATOM   2313 C CA  . CYS B 2 88  ? -1.208  -12.947 25.140  1.00 27.77 ? 88  CYS L CA  1 
ATOM   2314 C C   . CYS B 2 88  ? -1.558  -11.605 24.520  1.00 28.58 ? 88  CYS L C   1 
ATOM   2315 O O   . CYS B 2 88  ? -2.704  -11.152 24.562  1.00 25.95 ? 88  CYS L O   1 
ATOM   2316 C CB  . CYS B 2 88  ? -1.045  -14.010 24.051  1.00 25.99 ? 88  CYS L CB  1 
ATOM   2317 S SG  . CYS B 2 88  ? -2.554  -14.394 23.180  1.00 37.03 ? 88  CYS L SG  1 
ATOM   2318 N N   . GLN B 2 89  ? -0.538  -10.963 23.969  1.00 28.98 ? 89  GLN L N   1 
ATOM   2319 C CA  . GLN B 2 89  ? -0.679  -9.736  23.201  1.00 23.13 ? 89  GLN L CA  1 
ATOM   2320 C C   . GLN B 2 89  ? 0.163   -9.890  21.946  1.00 30.56 ? 89  GLN L C   1 
ATOM   2321 O O   . GLN B 2 89  ? 1.352   -10.240 22.030  1.00 27.31 ? 89  GLN L O   1 
ATOM   2322 C CB  . GLN B 2 89  ? -0.226  -8.500  23.981  1.00 23.43 ? 89  GLN L CB  1 
ATOM   2323 C CG  . GLN B 2 89  ? -0.284  -7.243  23.111  1.00 24.75 ? 89  GLN L CG  1 
ATOM   2324 C CD  . GLN B 2 89  ? 0.411   -6.045  23.723  1.00 28.42 ? 89  GLN L CD  1 
ATOM   2325 O OE1 . GLN B 2 89  ? 0.958   -6.120  24.824  1.00 28.29 ? 89  GLN L OE1 1 
ATOM   2326 N NE2 . GLN B 2 89  ? 0.394   -4.928  23.006  1.00 19.81 ? 89  GLN L NE2 1 
ATOM   2327 N N   . ILE B 2 90  ? -0.472  -9.682  20.795  1.00 23.96 ? 90  ILE L N   1 
ATOM   2328 C CA  . ILE B 2 90  ? 0.166   -9.754  19.489  1.00 21.52 ? 90  ILE L CA  1 
ATOM   2329 C C   . ILE B 2 90  ? -0.138  -8.422  18.826  1.00 27.11 ? 90  ILE L C   1 
ATOM   2330 O O   . ILE B 2 90  ? -1.312  -8.116  18.551  1.00 25.39 ? 90  ILE L O   1 
ATOM   2331 C CB  . ILE B 2 90  ? -0.367  -10.920 18.653  1.00 25.40 ? 90  ILE L CB  1 
ATOM   2332 C CG1 . ILE B 2 90  ? 0.059   -12.247 19.303  1.00 27.13 ? 90  ILE L CG1 1 
ATOM   2333 C CG2 . ILE B 2 90  ? 0.054   -10.775 17.169  1.00 22.31 ? 90  ILE L CG2 1 
ATOM   2334 C CD1 . ILE B 2 90  ? -0.596  -13.485 18.733  1.00 30.93 ? 90  ILE L CD1 1 
ATOM   2335 N N   . TYR B 2 91  ? 0.905   -7.622  18.596  1.00 24.08 ? 91  TYR L N   1 
ATOM   2336 C CA  . TYR B 2 91  ? 0.727   -6.222  18.227  1.00 24.60 ? 91  TYR L CA  1 
ATOM   2337 C C   . TYR B 2 91  ? -0.336  -5.583  19.115  1.00 25.85 ? 91  TYR L C   1 
ATOM   2338 O O   . TYR B 2 91  ? -0.176  -5.572  20.340  1.00 25.03 ? 91  TYR L O   1 
ATOM   2339 C CB  . TYR B 2 91  ? 0.413   -6.108  16.739  1.00 25.05 ? 91  TYR L CB  1 
ATOM   2340 C CG  . TYR B 2 91  ? 1.627   -6.515  15.929  1.00 26.53 ? 91  TYR L CG  1 
ATOM   2341 C CD1 . TYR B 2 91  ? 2.640   -5.607  15.666  1.00 28.02 ? 91  TYR L CD1 1 
ATOM   2342 C CD2 . TYR B 2 91  ? 1.780   -7.824  15.473  1.00 23.78 ? 91  TYR L CD2 1 
ATOM   2343 C CE1 . TYR B 2 91  ? 3.776   -5.990  14.932  1.00 30.32 ? 91  TYR L CE1 1 
ATOM   2344 C CE2 . TYR B 2 91  ? 2.887   -8.206  14.747  1.00 29.64 ? 91  TYR L CE2 1 
ATOM   2345 C CZ  . TYR B 2 91  ? 3.886   -7.293  14.479  1.00 29.05 ? 91  TYR L CZ  1 
ATOM   2346 O OH  . TYR B 2 91  ? 4.994   -7.704  13.754  1.00 34.22 ? 91  TYR L OH  1 
ATOM   2347 N N   . GLU B 2 92  ? -1.420  -5.053  18.549  1.00 24.28 ? 96  GLU L N   1 
ATOM   2348 C CA  . GLU B 2 92  ? -2.386  -4.374  19.408  1.00 26.30 ? 96  GLU L CA  1 
ATOM   2349 C C   . GLU B 2 92  ? -3.520  -5.289  19.884  1.00 21.25 ? 96  GLU L C   1 
ATOM   2350 O O   . GLU B 2 92  ? -4.396  -4.834  20.623  1.00 26.65 ? 96  GLU L O   1 
ATOM   2351 C CB  . GLU B 2 92  ? -2.952  -3.127  18.700  1.00 22.36 ? 96  GLU L CB  1 
ATOM   2352 C CG  . GLU B 2 92  ? -3.899  -3.398  17.535  1.00 24.49 ? 96  GLU L CG  1 
ATOM   2353 C CD  . GLU B 2 92  ? -3.205  -3.485  16.179  1.00 24.39 ? 96  GLU L CD  1 
ATOM   2354 O OE1 . GLU B 2 92  ? -2.277  -4.317  16.027  1.00 23.47 ? 96  GLU L OE1 1 
ATOM   2355 O OE2 . GLU B 2 92  ? -3.592  -2.723  15.257  1.00 23.75 ? 96  GLU L OE2 1 
ATOM   2356 N N   . THR B 2 93  ? -3.528  -6.554  19.486  1.00 21.64 ? 97  THR L N   1 
ATOM   2357 C CA  . THR B 2 93  ? -4.617  -7.474  19.803  1.00 24.17 ? 97  THR L CA  1 
ATOM   2358 C C   . THR B 2 93  ? -4.286  -8.273  21.066  1.00 27.76 ? 97  THR L C   1 
ATOM   2359 O O   . THR B 2 93  ? -3.250  -8.947  21.116  1.00 22.88 ? 97  THR L O   1 
ATOM   2360 C CB  . THR B 2 93  ? -4.860  -8.437  18.647  1.00 25.77 ? 97  THR L CB  1 
ATOM   2361 O OG1 . THR B 2 93  ? -5.010  -7.698  17.429  1.00 22.70 ? 97  THR L OG1 1 
ATOM   2362 C CG2 . THR B 2 93  ? -6.124  -9.293  18.917  1.00 29.45 ? 97  THR L CG2 1 
ATOM   2363 N N   . PHE B 2 94  ? -5.178  -8.228  22.067  1.00 25.70 ? 98  PHE L N   1 
ATOM   2364 C CA  . PHE B 2 94  ? -5.068  -9.097  23.239  1.00 29.50 ? 98  PHE L CA  1 
ATOM   2365 C C   . PHE B 2 94  ? -5.835  -10.398 23.034  1.00 26.27 ? 98  PHE L C   1 
ATOM   2366 O O   . PHE B 2 94  ? -6.904  -10.421 22.424  1.00 27.44 ? 98  PHE L O   1 
ATOM   2367 C CB  . PHE B 2 94  ? -5.563  -8.387  24.499  1.00 26.05 ? 98  PHE L CB  1 
ATOM   2368 C CG  . PHE B 2 94  ? -4.573  -7.390  25.035  1.00 26.75 ? 98  PHE L CG  1 
ATOM   2369 C CD1 . PHE B 2 94  ? -3.567  -7.794  25.894  1.00 22.75 ? 98  PHE L CD1 1 
ATOM   2370 C CD2 . PHE B 2 94  ? -4.617  -6.059  24.634  1.00 25.85 ? 98  PHE L CD2 1 
ATOM   2371 C CE1 . PHE B 2 94  ? -2.644  -6.896  26.365  1.00 23.94 ? 98  PHE L CE1 1 
ATOM   2372 C CE2 . PHE B 2 94  ? -3.686  -5.157  25.104  1.00 29.49 ? 98  PHE L CE2 1 
ATOM   2373 C CZ  . PHE B 2 94  ? -2.689  -5.578  25.957  1.00 24.77 ? 98  PHE L CZ  1 
ATOM   2374 N N   . GLY B 2 95  ? -5.273  -11.494 23.530  1.00 30.78 ? 99  GLY L N   1 
ATOM   2375 C CA  . GLY B 2 95  ? -6.016  -12.730 23.525  1.00 26.52 ? 99  GLY L CA  1 
ATOM   2376 C C   . GLY B 2 95  ? -7.190  -12.671 24.487  1.00 27.40 ? 99  GLY L C   1 
ATOM   2377 O O   . GLY B 2 95  ? -7.299  -11.794 25.345  1.00 26.67 ? 99  GLY L O   1 
ATOM   2378 N N   . GLN B 2 96  ? -8.076  -13.661 24.356  1.00 30.73 ? 100 GLN L N   1 
ATOM   2379 C CA  . GLN B 2 96  ? -9.295  -13.692 25.154  1.00 31.14 ? 100 GLN L CA  1 
ATOM   2380 C C   . GLN B 2 96  ? -9.027  -13.964 26.625  1.00 33.72 ? 100 GLN L C   1 
ATOM   2381 O O   . GLN B 2 96  ? -9.897  -13.693 27.462  1.00 38.26 ? 100 GLN L O   1 
ATOM   2382 C CB  . GLN B 2 96  ? -10.253 -14.750 24.609  1.00 31.18 ? 100 GLN L CB  1 
ATOM   2383 C CG  . GLN B 2 96  ? -10.700 -14.521 23.164  1.00 36.98 ? 100 GLN L CG  1 
ATOM   2384 C CD  . GLN B 2 96  ? -9.600  -14.786 22.131  1.00 36.22 ? 100 GLN L CD  1 
ATOM   2385 O OE1 . GLN B 2 96  ? -8.505  -15.238 22.464  1.00 37.23 ? 100 GLN L OE1 1 
ATOM   2386 N NE2 . GLN B 2 96  ? -9.890  -14.482 20.873  1.00 42.44 ? 100 GLN L NE2 1 
ATOM   2387 N N   . GLY B 2 97  ? -7.852  -14.489 26.966  1.00 28.30 ? 101 GLY L N   1 
ATOM   2388 C CA  . GLY B 2 97  ? -7.555  -14.768 28.356  1.00 29.96 ? 101 GLY L CA  1 
ATOM   2389 C C   . GLY B 2 97  ? -7.747  -16.229 28.734  1.00 34.98 ? 101 GLY L C   1 
ATOM   2390 O O   . GLY B 2 97  ? -8.675  -16.899 28.256  1.00 27.75 ? 101 GLY L O   1 
ATOM   2391 N N   . THR B 2 98  ? -6.845  -16.729 29.579  1.00 32.00 ? 102 THR L N   1 
ATOM   2392 C CA  . THR B 2 98  ? -6.910  -18.074 30.139  1.00 29.88 ? 102 THR L CA  1 
ATOM   2393 C C   . THR B 2 98  ? -6.847  -17.962 31.660  1.00 27.71 ? 102 THR L C   1 
ATOM   2394 O O   . THR B 2 98  ? -5.872  -17.437 32.199  1.00 27.85 ? 102 THR L O   1 
ATOM   2395 C CB  . THR B 2 98  ? -5.751  -18.939 29.618  1.00 28.67 ? 102 THR L CB  1 
ATOM   2396 O OG1 . THR B 2 98  ? -5.808  -19.033 28.186  1.00 30.26 ? 102 THR L OG1 1 
ATOM   2397 C CG2 . THR B 2 98  ? -5.784  -20.345 30.240  1.00 28.12 ? 102 THR L CG2 1 
ATOM   2398 N N   . LYS B 2 99  ? -7.870  -18.464 32.351  1.00 29.65 ? 103 LYS L N   1 
ATOM   2399 C CA  . LYS B 2 99  ? -7.870  -18.483 33.813  1.00 33.53 ? 103 LYS L CA  1 
ATOM   2400 C C   . LYS B 2 99  ? -7.431  -19.857 34.311  1.00 31.25 ? 103 LYS L C   1 
ATOM   2401 O O   . LYS B 2 99  ? -7.970  -20.884 33.880  1.00 30.18 ? 103 LYS L O   1 
ATOM   2402 C CB  . LYS B 2 99  ? -9.242  -18.129 34.391  1.00 32.12 ? 103 LYS L CB  1 
ATOM   2403 C CG  . LYS B 2 99  ? -9.199  -17.775 35.889  1.00 32.94 ? 103 LYS L CG  1 
ATOM   2404 C CD  . LYS B 2 99  ? -10.589 -17.419 36.372  1.00 42.66 ? 103 LYS L CD  1 
ATOM   2405 C CE  . LYS B 2 99  ? -10.599 -17.026 37.837  1.00 49.07 ? 103 LYS L CE  1 
ATOM   2406 N NZ  . LYS B 2 99  ? -11.919 -16.396 38.208  1.00 45.62 ? 103 LYS L NZ  1 
ATOM   2407 N N   . VAL B 2 100 ? -6.441  -19.868 35.201  1.00 28.22 ? 104 VAL L N   1 
ATOM   2408 C CA  . VAL B 2 100 ? -5.871  -21.096 35.739  1.00 29.68 ? 104 VAL L CA  1 
ATOM   2409 C C   . VAL B 2 100 ? -6.428  -21.276 37.146  1.00 28.63 ? 104 VAL L C   1 
ATOM   2410 O O   . VAL B 2 100 ? -6.081  -20.518 38.051  1.00 28.17 ? 104 VAL L O   1 
ATOM   2411 C CB  . VAL B 2 100 ? -4.335  -21.052 35.741  1.00 33.01 ? 104 VAL L CB  1 
ATOM   2412 C CG1 . VAL B 2 100 ? -3.743  -22.372 36.291  1.00 29.02 ? 104 VAL L CG1 1 
ATOM   2413 C CG2 . VAL B 2 100 ? -3.812  -20.747 34.344  1.00 32.23 ? 104 VAL L CG2 1 
ATOM   2414 N N   . ASP B 2 101 ? -7.293  -22.277 37.320  1.00 33.91 ? 105 ASP L N   1 
ATOM   2415 C CA  . ASP B 2 101 ? -7.956  -22.628 38.573  1.00 35.40 ? 105 ASP L CA  1 
ATOM   2416 C C   . ASP B 2 101 ? -7.247  -23.799 39.257  1.00 36.37 ? 105 ASP L C   1 
ATOM   2417 O O   . ASP B 2 101 ? -6.545  -24.583 38.619  1.00 30.89 ? 105 ASP L O   1 
ATOM   2418 C CB  . ASP B 2 101 ? -9.409  -23.019 38.313  1.00 34.61 ? 105 ASP L CB  1 
ATOM   2419 C CG  . ASP B 2 101 ? -10.178 -21.952 37.573  1.00 41.92 ? 105 ASP L CG  1 
ATOM   2420 O OD1 . ASP B 2 101 ? -10.084 -20.775 37.989  1.00 40.66 ? 105 ASP L OD1 1 
ATOM   2421 O OD2 . ASP B 2 101 ? -10.875 -22.291 36.579  1.00 40.38 ? 105 ASP L OD2 1 
ATOM   2422 N N   . ILE B 2 102 ? -7.481  -23.924 40.564  1.00 38.53 ? 106 ILE L N   1 
ATOM   2423 C CA  . ILE B 2 102 ? -6.846  -25.007 41.370  1.00 38.29 ? 106 ILE L CA  1 
ATOM   2424 C C   . ILE B 2 102 ? -7.744  -26.243 41.411  1.00 41.45 ? 106 ILE L C   1 
ATOM   2425 O O   . ILE B 2 102 ? -8.912  -26.119 41.775  1.00 38.23 ? 106 ILE L O   1 
ATOM   2426 C CB  . ILE B 2 102 ? -6.533  -24.540 42.803  1.00 42.92 ? 106 ILE L CB  1 
ATOM   2427 C CG1 . ILE B 2 102 ? -6.126  -23.067 42.853  1.00 43.27 ? 106 ILE L CG1 1 
ATOM   2428 C CG2 . ILE B 2 102 ? -5.481  -25.434 43.438  1.00 42.89 ? 106 ILE L CG2 1 
ATOM   2429 C CD1 . ILE B 2 102 ? -6.234  -22.449 44.223  1.00 48.86 ? 106 ILE L CD1 1 
ATOM   2430 N N   . LYS B 2 103 ? -7.178  -27.397 41.084  1.00 42.98 ? 107 LYS L N   1 
ATOM   2431 C CA  . LYS B 2 103 ? -7.929  -28.670 41.179  1.00 45.68 ? 107 LYS L CA  1 
ATOM   2432 C C   . LYS B 2 103 ? -8.001  -29.108 42.649  1.00 49.57 ? 107 LYS L C   1 
ATOM   2433 O O   . LYS B 2 103 ? -7.008  -28.915 43.361  1.00 41.78 ? 107 LYS L O   1 
ATOM   2434 C CB  . LYS B 2 103 ? -7.235  -29.708 40.293  1.00 43.43 ? 107 LYS L CB  1 
ATOM   2435 C CG  . LYS B 2 103 ? -8.138  -30.627 39.487  1.00 44.54 ? 107 LYS L CG  1 
ATOM   2436 C CD  . LYS B 2 103 ? -7.358  -31.510 38.535  1.00 41.04 ? 107 LYS L CD  1 
ATOM   2437 C CE  . LYS B 2 103 ? -6.144  -32.148 39.177  1.00 47.42 ? 107 LYS L CE  1 
ATOM   2438 N NZ  . LYS B 2 103 ? -5.042  -32.371 38.210  1.00 44.54 ? 107 LYS L NZ  1 
ATOM   2439 N N   . ARG B 2 104 ? -9.144  -29.641 43.084  1.00 41.94 ? 108 ARG L N   1 
ATOM   2440 C CA  . ARG B 2 104 ? -9.296  -30.195 44.460  1.00 37.08 ? 108 ARG L CA  1 
ATOM   2441 C C   . ARG B 2 104 ? -10.466 -31.191 44.453  1.00 37.01 ? 108 ARG L C   1 
ATOM   2442 O O   . ARG B 2 104 ? -11.113 -31.311 43.411  1.00 39.26 ? 108 ARG L O   1 
ATOM   2443 C CB  . ARG B 2 104 ? -9.453  -29.075 45.491  1.00 35.63 ? 108 ARG L CB  1 
ATOM   2444 C CG  . ARG B 2 104 ? -10.711 -28.240 45.330  1.00 36.98 ? 108 ARG L CG  1 
ATOM   2445 C CD  . ARG B 2 104 ? -11.337 -27.895 46.664  1.00 36.04 ? 108 ARG L CD  1 
ATOM   2446 N NE  . ARG B 2 104 ? -11.817 -29.089 47.340  1.00 38.78 ? 108 ARG L NE  1 
ATOM   2447 C CZ  . ARG B 2 104 ? -11.787 -29.273 48.652  1.00 40.79 ? 108 ARG L CZ  1 
ATOM   2448 N NH1 . ARG B 2 104 ? -11.187 -28.392 49.431  1.00 32.73 ? 108 ARG L NH1 1 
ATOM   2449 N NH2 . ARG B 2 104 ? -12.359 -30.339 49.183  1.00 37.31 ? 108 ARG L NH2 1 
ATOM   2450 N N   . THR B 2 105 ? -10.703 -31.898 45.564  1.00 32.70 ? 109 THR L N   1 
ATOM   2451 C CA  . THR B 2 105 ? -11.768 -32.878 45.572  1.00 39.27 ? 109 THR L CA  1 
ATOM   2452 C C   . THR B 2 105 ? -13.125 -32.193 45.700  1.00 38.75 ? 109 THR L C   1 
ATOM   2453 O O   . THR B 2 105 ? -13.240 -31.059 46.176  1.00 39.26 ? 109 THR L O   1 
ATOM   2454 C CB  . THR B 2 105 ? -11.567 -33.874 46.714  1.00 42.71 ? 109 THR L CB  1 
ATOM   2455 O OG1 . THR B 2 105 ? -11.192 -33.157 47.901  1.00 41.61 ? 109 THR L OG1 1 
ATOM   2456 C CG2 . THR B 2 105 ? -10.471 -34.879 46.346  1.00 35.39 ? 109 THR L CG2 1 
ATOM   2457 N N   . VAL B 2 106 ? -14.164 -32.906 45.268  1.00 37.40 ? 110 VAL L N   1 
ATOM   2458 C CA  . VAL B 2 106 ? -15.517 -32.393 45.419  1.00 34.94 ? 110 VAL L CA  1 
ATOM   2459 C C   . VAL B 2 106 ? -15.810 -32.150 46.892  1.00 37.23 ? 110 VAL L C   1 
ATOM   2460 O O   . VAL B 2 106 ? -15.397 -32.922 47.767  1.00 37.29 ? 110 VAL L O   1 
ATOM   2461 C CB  . VAL B 2 106 ? -16.537 -33.362 44.804  1.00 37.48 ? 110 VAL L CB  1 
ATOM   2462 C CG1 . VAL B 2 106 ? -17.934 -32.818 44.962  1.00 32.36 ? 110 VAL L CG1 1 
ATOM   2463 C CG2 . VAL B 2 106 ? -16.223 -33.590 43.341  1.00 41.63 ? 110 VAL L CG2 1 
ATOM   2464 N N   . ALA B 2 107 ? -16.502 -31.042 47.168  1.00 35.87 ? 111 ALA L N   1 
ATOM   2465 C CA  . ALA B 2 107 ? -16.919 -30.661 48.509  1.00 36.02 ? 111 ALA L CA  1 
ATOM   2466 C C   . ALA B 2 107 ? -18.360 -30.180 48.445  1.00 35.87 ? 111 ALA L C   1 
ATOM   2467 O O   . ALA B 2 107 ? -18.713 -29.355 47.592  1.00 31.38 ? 111 ALA L O   1 
ATOM   2468 C CB  . ALA B 2 107 ? -16.004 -29.571 49.094  1.00 36.42 ? 111 ALA L CB  1 
ATOM   2469 N N   . ALA B 2 108 ? -19.188 -30.722 49.311  1.00 31.42 ? 112 ALA L N   1 
ATOM   2470 C CA  . ALA B 2 108 ? -20.577 -30.317 49.339  1.00 33.02 ? 112 ALA L CA  1 
ATOM   2471 C C   . ALA B 2 108 ? -20.717 -28.971 50.055  1.00 36.00 ? 112 ALA L C   1 
ATOM   2472 O O   . ALA B 2 108 ? -19.931 -28.654 50.955  1.00 31.43 ? 112 ALA L O   1 
ATOM   2473 C CB  . ALA B 2 108 ? -21.424 -31.380 50.032  1.00 31.91 ? 112 ALA L CB  1 
ATOM   2474 N N   . PRO B 2 109 ? -21.674 -28.138 49.647  1.00 30.32 ? 113 PRO L N   1 
ATOM   2475 C CA  . PRO B 2 109 ? -21.845 -26.831 50.307  1.00 34.89 ? 113 PRO L CA  1 
ATOM   2476 C C   . PRO B 2 109 ? -22.536 -26.943 51.653  1.00 27.10 ? 113 PRO L C   1 
ATOM   2477 O O   . PRO B 2 109 ? -23.392 -27.796 51.867  1.00 29.91 ? 113 PRO L O   1 
ATOM   2478 C CB  . PRO B 2 109 ? -22.718 -26.039 49.323  1.00 28.84 ? 113 PRO L CB  1 
ATOM   2479 C CG  . PRO B 2 109 ? -23.469 -27.092 48.573  1.00 34.24 ? 113 PRO L CG  1 
ATOM   2480 C CD  . PRO B 2 109 ? -22.493 -28.255 48.435  1.00 31.90 ? 113 PRO L CD  1 
ATOM   2481 N N   . SER B 2 110 ? -22.152 -26.058 52.572  1.00 34.89 ? 114 SER L N   1 
ATOM   2482 C CA  . SER B 2 110 ? -22.975 -25.788 53.742  1.00 31.34 ? 114 SER L CA  1 
ATOM   2483 C C   . SER B 2 110 ? -23.997 -24.734 53.344  1.00 29.88 ? 114 SER L C   1 
ATOM   2484 O O   . SER B 2 110 ? -23.626 -23.679 52.835  1.00 31.84 ? 114 SER L O   1 
ATOM   2485 C CB  . SER B 2 110 ? -22.121 -25.306 54.905  1.00 27.70 ? 114 SER L CB  1 
ATOM   2486 O OG  . SER B 2 110 ? -21.149 -26.289 55.212  1.00 41.15 ? 114 SER L OG  1 
ATOM   2487 N N   . VAL B 2 111 ? -25.274 -25.025 53.538  1.00 26.12 ? 115 VAL L N   1 
ATOM   2488 C CA  . VAL B 2 111 ? -26.342 -24.170 53.025  1.00 26.47 ? 115 VAL L CA  1 
ATOM   2489 C C   . VAL B 2 111 ? -27.039 -23.493 54.194  1.00 33.09 ? 115 VAL L C   1 
ATOM   2490 O O   . VAL B 2 111 ? -27.454 -24.152 55.159  1.00 31.29 ? 115 VAL L O   1 
ATOM   2491 C CB  . VAL B 2 111 ? -27.338 -24.948 52.153  1.00 26.29 ? 115 VAL L CB  1 
ATOM   2492 C CG1 . VAL B 2 111 ? -28.381 -24.010 51.550  1.00 26.14 ? 115 VAL L CG1 1 
ATOM   2493 C CG2 . VAL B 2 111 ? -26.606 -25.666 51.040  1.00 27.59 ? 115 VAL L CG2 1 
ATOM   2494 N N   . PHE B 2 112 ? -27.159 -22.175 54.107  1.00 29.16 ? 116 PHE L N   1 
ATOM   2495 C CA  . PHE B 2 112 ? -27.802 -21.373 55.129  1.00 27.17 ? 116 PHE L CA  1 
ATOM   2496 C C   . PHE B 2 112 ? -28.761 -20.413 54.455  1.00 32.36 ? 116 PHE L C   1 
ATOM   2497 O O   . PHE B 2 112 ? -28.574 -20.048 53.288  1.00 32.03 ? 116 PHE L O   1 
ATOM   2498 C CB  . PHE B 2 112 ? -26.785 -20.600 55.946  1.00 29.87 ? 116 PHE L CB  1 
ATOM   2499 C CG  . PHE B 2 112 ? -25.794 -21.475 56.636  1.00 30.92 ? 116 PHE L CG  1 
ATOM   2500 C CD1 . PHE B 2 112 ? -26.190 -22.268 57.699  1.00 35.35 ? 116 PHE L CD1 1 
ATOM   2501 C CD2 . PHE B 2 112 ? -24.479 -21.531 56.214  1.00 28.88 ? 116 PHE L CD2 1 
ATOM   2502 C CE1 . PHE B 2 112 ? -25.290 -23.086 58.352  1.00 36.36 ? 116 PHE L CE1 1 
ATOM   2503 C CE2 . PHE B 2 112 ? -23.572 -22.336 56.862  1.00 36.94 ? 116 PHE L CE2 1 
ATOM   2504 C CZ  . PHE B 2 112 ? -23.979 -23.116 57.938  1.00 36.25 ? 116 PHE L CZ  1 
ATOM   2505 N N   . ILE B 2 113 ? -29.797 -20.016 55.189  1.00 25.99 ? 117 ILE L N   1 
ATOM   2506 C CA  . ILE B 2 113 ? -30.747 -19.040 54.686  1.00 26.09 ? 117 ILE L CA  1 
ATOM   2507 C C   . ILE B 2 113 ? -30.978 -17.966 55.747  1.00 30.95 ? 117 ILE L C   1 
ATOM   2508 O O   . ILE B 2 113 ? -30.849 -18.205 56.953  1.00 25.77 ? 117 ILE L O   1 
ATOM   2509 C CB  . ILE B 2 113 ? -32.056 -19.730 54.244  1.00 26.79 ? 117 ILE L CB  1 
ATOM   2510 C CG1 . ILE B 2 113 ? -32.983 -18.773 53.497  1.00 25.43 ? 117 ILE L CG1 1 
ATOM   2511 C CG2 . ILE B 2 113 ? -32.751 -20.415 55.407  1.00 28.18 ? 117 ILE L CG2 1 
ATOM   2512 C CD1 . ILE B 2 113 ? -34.054 -19.532 52.729  1.00 23.67 ? 117 ILE L CD1 1 
ATOM   2513 N N   . PHE B 2 114 ? -31.283 -16.759 55.274  1.00 27.31 ? 118 PHE L N   1 
ATOM   2514 C CA  . PHE B 2 114 ? -31.483 -15.592 56.128  1.00 28.04 ? 118 PHE L CA  1 
ATOM   2515 C C   . PHE B 2 114 ? -32.770 -14.900 55.700  1.00 28.86 ? 118 PHE L C   1 
ATOM   2516 O O   . PHE B 2 114 ? -32.886 -14.477 54.531  1.00 27.80 ? 118 PHE L O   1 
ATOM   2517 C CB  . PHE B 2 114 ? -30.302 -14.633 56.027  1.00 23.30 ? 118 PHE L CB  1 
ATOM   2518 C CG  . PHE B 2 114 ? -29.025 -15.181 56.586  1.00 25.42 ? 118 PHE L CG  1 
ATOM   2519 C CD1 . PHE B 2 114 ? -28.812 -15.208 57.957  1.00 24.97 ? 118 PHE L CD1 1 
ATOM   2520 C CD2 . PHE B 2 114 ? -28.020 -15.638 55.752  1.00 22.72 ? 118 PHE L CD2 1 
ATOM   2521 C CE1 . PHE B 2 114 ? -27.630 -15.674 58.483  1.00 25.88 ? 118 PHE L CE1 1 
ATOM   2522 C CE2 . PHE B 2 114 ? -26.826 -16.114 56.278  1.00 27.67 ? 118 PHE L CE2 1 
ATOM   2523 C CZ  . PHE B 2 114 ? -26.631 -16.138 57.647  1.00 26.45 ? 118 PHE L CZ  1 
ATOM   2524 N N   . PRO B 2 115 ? -33.757 -14.789 56.577  1.00 30.89 ? 119 PRO L N   1 
ATOM   2525 C CA  . PRO B 2 115 ? -34.971 -14.051 56.251  1.00 34.06 ? 119 PRO L CA  1 
ATOM   2526 C C   . PRO B 2 115 ? -34.670 -12.569 56.111  1.00 29.46 ? 119 PRO L C   1 
ATOM   2527 O O   . PRO B 2 115 ? -33.573 -12.123 56.480  1.00 27.34 ? 119 PRO L O   1 
ATOM   2528 C CB  . PRO B 2 115 ? -35.881 -14.327 57.458  1.00 39.29 ? 119 PRO L CB  1 
ATOM   2529 C CG  . PRO B 2 115 ? -35.337 -15.572 58.052  1.00 38.01 ? 119 PRO L CG  1 
ATOM   2530 C CD  . PRO B 2 115 ? -33.869 -15.503 57.856  1.00 31.75 ? 119 PRO L CD  1 
ATOM   2531 N N   . PRO B 2 116 ? -35.596 -11.785 55.547  1.00 29.10 ? 120 PRO L N   1 
ATOM   2532 C CA  . PRO B 2 116 ? -35.400 -10.324 55.513  1.00 31.97 ? 120 PRO L CA  1 
ATOM   2533 C C   . PRO B 2 116 ? -35.319 -9.759  56.917  1.00 30.04 ? 120 PRO L C   1 
ATOM   2534 O O   . PRO B 2 116 ? -36.011 -10.213 57.830  1.00 28.95 ? 120 PRO L O   1 
ATOM   2535 C CB  . PRO B 2 116 ? -36.654 -9.802  54.796  1.00 25.60 ? 120 PRO L CB  1 
ATOM   2536 C CG  . PRO B 2 116 ? -37.295 -11.021 54.160  1.00 32.92 ? 120 PRO L CG  1 
ATOM   2537 C CD  . PRO B 2 116 ? -36.897 -12.188 54.981  1.00 29.34 ? 120 PRO L CD  1 
ATOM   2538 N N   . SER B 2 117 ? -34.495 -8.728  57.078  1.00 24.63 ? 121 SER L N   1 
ATOM   2539 C CA  . SER B 2 117 ? -34.443 -8.056  58.371  1.00 30.14 ? 121 SER L CA  1 
ATOM   2540 C C   . SER B 2 117 ? -35.705 -7.225  58.596  1.00 29.70 ? 121 SER L C   1 
ATOM   2541 O O   . SER B 2 117 ? -36.413 -6.841  57.656  1.00 30.25 ? 121 SER L O   1 
ATOM   2542 C CB  . SER B 2 117 ? -33.209 -7.158  58.472  1.00 27.79 ? 121 SER L CB  1 
ATOM   2543 O OG  . SER B 2 117 ? -33.350 -6.039  57.624  1.00 29.13 ? 121 SER L OG  1 
ATOM   2544 N N   . ASP B 2 118 ? -35.995 -6.945  59.868  1.00 33.47 ? 122 ASP L N   1 
ATOM   2545 C CA  . ASP B 2 118 ? -37.112 -6.047  60.150  1.00 38.59 ? 122 ASP L CA  1 
ATOM   2546 C C   . ASP B 2 118 ? -36.858 -4.659  59.586  1.00 33.48 ? 122 ASP L C   1 
ATOM   2547 O O   . ASP B 2 118 ? -37.775 -4.031  59.033  1.00 37.10 ? 122 ASP L O   1 
ATOM   2548 C CB  . ASP B 2 118 ? -37.380 -5.959  61.649  1.00 43.17 ? 122 ASP L CB  1 
ATOM   2549 C CG  . ASP B 2 118 ? -38.531 -6.823  62.073  1.00 51.56 ? 122 ASP L CG  1 
ATOM   2550 O OD1 . ASP B 2 118 ? -39.660 -6.567  61.592  1.00 54.59 ? 122 ASP L OD1 1 
ATOM   2551 O OD2 . ASP B 2 118 ? -38.305 -7.764  62.867  1.00 58.52 ? 122 ASP L OD2 1 
ATOM   2552 N N   . GLU B 2 119 ? -35.625 -4.154  59.722  1.00 31.94 ? 123 GLU L N   1 
ATOM   2553 C CA  . GLU B 2 119 ? -35.366 -2.794  59.257  1.00 33.96 ? 123 GLU L CA  1 
ATOM   2554 C C   . GLU B 2 119 ? -35.584 -2.691  57.756  1.00 34.00 ? 123 GLU L C   1 
ATOM   2555 O O   . GLU B 2 119 ? -36.138 -1.697  57.275  1.00 36.11 ? 123 GLU L O   1 
ATOM   2556 C CB  . GLU B 2 119 ? -33.962 -2.307  59.652  1.00 30.42 ? 123 GLU L CB  1 
ATOM   2557 C CG  . GLU B 2 119 ? -32.837 -3.337  59.617  1.00 36.32 ? 123 GLU L CG  1 
ATOM   2558 C CD  . GLU B 2 119 ? -32.627 -4.064  60.960  1.00 41.83 ? 123 GLU L CD  1 
ATOM   2559 O OE1 . GLU B 2 119 ? -33.445 -4.957  61.319  1.00 39.53 ? 123 GLU L OE1 1 
ATOM   2560 O OE2 . GLU B 2 119 ? -31.624 -3.750  61.651  1.00 42.03 ? 123 GLU L OE2 1 
ATOM   2561 N N   . GLN B 2 120 ? -35.173 -3.711  56.991  1.00 26.03 ? 124 GLN L N   1 
ATOM   2562 C CA  . GLN B 2 120 ? -35.495 -3.688  55.568  1.00 30.01 ? 124 GLN L CA  1 
ATOM   2563 C C   . GLN B 2 120 ? -36.999 -3.749  55.349  1.00 30.75 ? 124 GLN L C   1 
ATOM   2564 O O   . GLN B 2 120 ? -37.540 -3.019  54.511  1.00 33.68 ? 124 GLN L O   1 
ATOM   2565 C CB  . GLN B 2 120 ? -34.813 -4.834  54.818  1.00 28.47 ? 124 GLN L CB  1 
ATOM   2566 C CG  . GLN B 2 120 ? -35.026 -4.714  53.314  1.00 30.00 ? 124 GLN L CG  1 
ATOM   2567 C CD  . GLN B 2 120 ? -34.457 -5.887  52.505  1.00 31.91 ? 124 GLN L CD  1 
ATOM   2568 O OE1 . GLN B 2 120 ? -34.313 -7.006  53.007  1.00 31.21 ? 124 GLN L OE1 1 
ATOM   2569 N NE2 . GLN B 2 120 ? -34.148 -5.626  51.237  1.00 29.15 ? 124 GLN L NE2 1 
ATOM   2570 N N   . LEU B 2 121 ? -37.696 -4.611  56.095  1.00 31.43 ? 125 LEU L N   1 
ATOM   2571 C CA  . LEU B 2 121 ? -39.125 -4.794  55.847  1.00 32.71 ? 125 LEU L CA  1 
ATOM   2572 C C   . LEU B 2 121 ? -39.882 -3.478  56.007  1.00 37.51 ? 125 LEU L C   1 
ATOM   2573 O O   . LEU B 2 121 ? -40.700 -3.119  55.148  1.00 36.79 ? 125 LEU L O   1 
ATOM   2574 C CB  . LEU B 2 121 ? -39.687 -5.882  56.766  1.00 36.03 ? 125 LEU L CB  1 
ATOM   2575 C CG  . LEU B 2 121 ? -39.350 -7.320  56.329  1.00 33.46 ? 125 LEU L CG  1 
ATOM   2576 C CD1 . LEU B 2 121 ? -39.862 -8.351  57.336  1.00 37.16 ? 125 LEU L CD1 1 
ATOM   2577 C CD2 . LEU B 2 121 ? -39.898 -7.624  54.956  1.00 27.39 ? 125 LEU L CD2 1 
ATOM   2578 N N   . LYS B 2 122 ? -39.558 -2.707  57.054  1.00 40.03 ? 126 LYS L N   1 
ATOM   2579 C CA  . LYS B 2 122 ? -40.204 -1.408  57.259  1.00 42.32 ? 126 LYS L CA  1 
ATOM   2580 C C   . LYS B 2 122 ? -40.086 -0.514  56.038  1.00 45.71 ? 126 LYS L C   1 
ATOM   2581 O O   . LYS B 2 122 ? -40.971 0.317   55.792  1.00 42.49 ? 126 LYS L O   1 
ATOM   2582 C CB  . LYS B 2 122 ? -39.593 -0.656  58.434  1.00 36.48 ? 126 LYS L CB  1 
ATOM   2583 C CG  . LYS B 2 122 ? -39.563 -1.360  59.758  1.00 40.71 ? 126 LYS L CG  1 
ATOM   2584 C CD  . LYS B 2 122 ? -38.601 -0.582  60.634  1.00 42.05 ? 126 LYS L CD  1 
ATOM   2585 C CE  . LYS B 2 122 ? -38.537 -1.090  62.056  1.00 47.88 ? 126 LYS L CE  1 
ATOM   2586 N NZ  . LYS B 2 122 ? -37.914 -0.032  62.916  1.00 42.88 ? 126 LYS L NZ  1 
ATOM   2587 N N   . SER B 2 123 ? -39.002 -0.650  55.267  1.00 42.84 ? 127 SER L N   1 
ATOM   2588 C CA  . SER B 2 123 ? -38.827 0.168   54.076  1.00 36.58 ? 127 SER L CA  1 
ATOM   2589 C C   . SER B 2 123 ? -39.497 -0.433  52.847  1.00 38.25 ? 127 SER L C   1 
ATOM   2590 O O   . SER B 2 123 ? -39.275 0.058   51.737  1.00 45.36 ? 127 SER L O   1 
ATOM   2591 C CB  . SER B 2 123 ? -37.331 0.429   53.808  1.00 38.91 ? 127 SER L CB  1 
ATOM   2592 O OG  . SER B 2 123 ? -36.593 -0.749  53.501  1.00 43.27 ? 127 SER L OG  1 
ATOM   2593 N N   . GLY B 2 124 ? -40.315 -1.469  53.010  1.00 37.72 ? 128 GLY L N   1 
ATOM   2594 C CA  . GLY B 2 124 ? -41.170 -1.927  51.930  1.00 34.81 ? 128 GLY L CA  1 
ATOM   2595 C C   . GLY B 2 124 ? -40.580 -2.962  50.995  1.00 36.90 ? 128 GLY L C   1 
ATOM   2596 O O   . GLY B 2 124 ? -41.226 -3.301  49.996  1.00 35.50 ? 128 GLY L O   1 
ATOM   2597 N N   . THR B 2 125 ? -39.396 -3.491  51.294  1.00 34.37 ? 129 THR L N   1 
ATOM   2598 C CA  . THR B 2 125 ? -38.743 -4.490  50.461  1.00 33.31 ? 129 THR L CA  1 
ATOM   2599 C C   . THR B 2 125 ? -38.310 -5.663  51.331  1.00 34.99 ? 129 THR L C   1 
ATOM   2600 O O   . THR B 2 125 ? -37.988 -5.497  52.511  1.00 32.16 ? 129 THR L O   1 
ATOM   2601 C CB  . THR B 2 125 ? -37.518 -3.885  49.711  1.00 32.92 ? 129 THR L CB  1 
ATOM   2602 O OG1 . THR B 2 125 ? -37.974 -2.896  48.784  1.00 36.75 ? 129 THR L OG1 1 
ATOM   2603 C CG2 . THR B 2 125 ? -36.766 -4.939  48.929  1.00 32.72 ? 129 THR L CG2 1 
ATOM   2604 N N   . ALA B 2 126 ? -38.324 -6.862  50.749  1.00 31.46 ? 130 ALA L N   1 
ATOM   2605 C CA  . ALA B 2 126 ? -37.859 -8.051  51.447  1.00 34.07 ? 130 ALA L CA  1 
ATOM   2606 C C   . ALA B 2 126 ? -36.787 -8.718  50.603  1.00 30.75 ? 130 ALA L C   1 
ATOM   2607 O O   . ALA B 2 126 ? -37.060 -9.136  49.475  1.00 26.40 ? 130 ALA L O   1 
ATOM   2608 C CB  . ALA B 2 126 ? -39.013 -9.017  51.714  1.00 29.72 ? 130 ALA L CB  1 
ATOM   2609 N N   . SER B 2 127 ? -35.584 -8.820  51.143  1.00 26.87 ? 131 SER L N   1 
ATOM   2610 C CA  . SER B 2 127 ? -34.527 -9.610  50.524  1.00 27.27 ? 131 SER L CA  1 
ATOM   2611 C C   . SER B 2 127 ? -34.285 -10.850 51.371  1.00 26.21 ? 131 SER L C   1 
ATOM   2612 O O   . SER B 2 127 ? -33.967 -10.733 52.560  1.00 31.44 ? 131 SER L O   1 
ATOM   2613 C CB  . SER B 2 127 ? -33.242 -8.796  50.385  1.00 25.93 ? 131 SER L CB  1 
ATOM   2614 O OG  . SER B 2 127 ? -33.449 -7.676  49.548  1.00 28.27 ? 131 SER L OG  1 
ATOM   2615 N N   . VAL B 2 128 ? -34.419 -12.025 50.755  1.00 27.35 ? 132 VAL L N   1 
ATOM   2616 C CA  . VAL B 2 128 ? -34.031 -13.299 51.360  1.00 25.09 ? 132 VAL L CA  1 
ATOM   2617 C C   . VAL B 2 128 ? -32.677 -13.690 50.803  1.00 27.46 ? 132 VAL L C   1 
ATOM   2618 O O   . VAL B 2 128 ? -32.464 -13.625 49.584  1.00 27.04 ? 132 VAL L O   1 
ATOM   2619 C CB  . VAL B 2 128 ? -35.064 -14.400 51.067  1.00 28.18 ? 132 VAL L CB  1 
ATOM   2620 C CG1 . VAL B 2 128 ? -34.764 -15.676 51.922  1.00 23.96 ? 132 VAL L CG1 1 
ATOM   2621 C CG2 . VAL B 2 128 ? -36.473 -13.883 51.294  1.00 27.65 ? 132 VAL L CG2 1 
ATOM   2622 N N   . VAL B 2 129 ? -31.767 -14.119 51.673  1.00 23.72 ? 133 VAL L N   1 
ATOM   2623 C CA  . VAL B 2 129 ? -30.410 -14.450 51.260  1.00 20.28 ? 133 VAL L CA  1 
ATOM   2624 C C   . VAL B 2 129 ? -30.138 -15.927 51.519  1.00 29.38 ? 133 VAL L C   1 
ATOM   2625 O O   . VAL B 2 129 ? -30.298 -16.408 52.650  1.00 27.39 ? 133 VAL L O   1 
ATOM   2626 C CB  . VAL B 2 129 ? -29.370 -13.579 51.977  1.00 27.34 ? 133 VAL L CB  1 
ATOM   2627 C CG1 . VAL B 2 129 ? -27.963 -14.080 51.657  1.00 21.17 ? 133 VAL L CG1 1 
ATOM   2628 C CG2 . VAL B 2 129 ? -29.552 -12.085 51.558  1.00 25.51 ? 133 VAL L CG2 1 
ATOM   2629 N N   . CYS B 2 130 ? -29.666 -16.619 50.485  1.00 28.44 ? 134 CYS L N   1 
ATOM   2630 C CA  . CYS B 2 130 ? -29.193 -17.998 50.579  1.00 29.08 ? 134 CYS L CA  1 
ATOM   2631 C C   . CYS B 2 130 ? -27.673 -18.024 50.457  1.00 30.10 ? 134 CYS L C   1 
ATOM   2632 O O   . CYS B 2 130 ? -27.115 -17.385 49.557  1.00 31.96 ? 134 CYS L O   1 
ATOM   2633 C CB  . CYS B 2 130 ? -29.824 -18.841 49.475  1.00 28.84 ? 134 CYS L CB  1 
ATOM   2634 S SG  . CYS B 2 130 ? -29.472 -20.656 49.484  1.00 32.79 ? 134 CYS L SG  1 
ATOM   2635 N N   . LEU B 2 131 ? -27.010 -18.773 51.344  1.00 23.22 ? 135 LEU L N   1 
ATOM   2636 C CA  . LEU B 2 131 ? -25.557 -18.867 51.395  1.00 25.37 ? 135 LEU L CA  1 
ATOM   2637 C C   . LEU B 2 131 ? -25.122 -20.316 51.193  1.00 31.71 ? 135 LEU L C   1 
ATOM   2638 O O   . LEU B 2 131 ? -25.564 -21.203 51.932  1.00 30.38 ? 135 LEU L O   1 
ATOM   2639 C CB  . LEU B 2 131 ? -25.021 -18.358 52.735  1.00 21.70 ? 135 LEU L CB  1 
ATOM   2640 C CG  . LEU B 2 131 ? -23.550 -18.673 53.052  1.00 25.56 ? 135 LEU L CG  1 
ATOM   2641 C CD1 . LEU B 2 131 ? -22.597 -17.962 52.088  1.00 27.46 ? 135 LEU L CD1 1 
ATOM   2642 C CD2 . LEU B 2 131 ? -23.242 -18.303 54.480  1.00 21.59 ? 135 LEU L CD2 1 
ATOM   2643 N N   . LEU B 2 132 ? -24.237 -20.547 50.213  1.00 22.75 ? 136 LEU L N   1 
ATOM   2644 C CA  . LEU B 2 132 ? -23.641 -21.855 49.966  1.00 28.44 ? 136 LEU L CA  1 
ATOM   2645 C C   . LEU B 2 132 ? -22.174 -21.722 50.327  1.00 28.15 ? 136 LEU L C   1 
ATOM   2646 O O   . LEU B 2 132 ? -21.432 -20.993 49.659  1.00 27.58 ? 136 LEU L O   1 
ATOM   2647 C CB  . LEU B 2 132 ? -23.782 -22.291 48.509  1.00 27.19 ? 136 LEU L CB  1 
ATOM   2648 C CG  . LEU B 2 132 ? -25.081 -22.777 47.892  1.00 25.79 ? 136 LEU L CG  1 
ATOM   2649 C CD1 . LEU B 2 132 ? -26.154 -21.712 47.904  1.00 33.81 ? 136 LEU L CD1 1 
ATOM   2650 C CD2 . LEU B 2 132 ? -24.769 -23.195 46.442  1.00 24.85 ? 136 LEU L CD2 1 
ATOM   2651 N N   . ASN B 2 133 ? -21.750 -22.404 51.376  1.00 22.57 ? 137 ASN L N   1 
ATOM   2652 C CA  . ASN B 2 133 ? -20.451 -22.124 51.960  1.00 30.80 ? 137 ASN L CA  1 
ATOM   2653 C C   . ASN B 2 133 ? -19.466 -23.246 51.644  1.00 33.50 ? 137 ASN L C   1 
ATOM   2654 O O   . ASN B 2 133 ? -19.714 -24.408 51.987  1.00 37.04 ? 137 ASN L O   1 
ATOM   2655 C CB  . ASN B 2 133 ? -20.588 -21.912 53.466  1.00 33.32 ? 137 ASN L CB  1 
ATOM   2656 C CG  . ASN B 2 133 ? -19.789 -20.724 53.945  1.00 37.11 ? 137 ASN L CG  1 
ATOM   2657 O OD1 . ASN B 2 133 ? -19.294 -19.932 53.139  1.00 39.84 ? 137 ASN L OD1 1 
ATOM   2658 N ND2 . ASN B 2 133 ? -19.658 -20.586 55.259  1.00 39.09 ? 137 ASN L ND2 1 
ATOM   2659 N N   . ASN B 2 134 ? -18.351 -22.890 50.999  1.00 30.61 ? 138 ASN L N   1 
ATOM   2660 C CA  . ASN B 2 134 ? -17.181 -23.763 50.856  1.00 34.05 ? 138 ASN L CA  1 
ATOM   2661 C C   . ASN B 2 134 ? -17.520 -25.074 50.133  1.00 34.70 ? 138 ASN L C   1 
ATOM   2662 O O   . ASN B 2 134 ? -17.537 -26.163 50.714  1.00 33.27 ? 138 ASN L O   1 
ATOM   2663 C CB  . ASN B 2 134 ? -16.543 -24.019 52.224  1.00 32.86 ? 138 ASN L CB  1 
ATOM   2664 C CG  . ASN B 2 134 ? -15.847 -22.794 52.763  1.00 35.16 ? 138 ASN L CG  1 
ATOM   2665 O OD1 . ASN B 2 134 ? -16.484 -21.791 53.037  1.00 38.43 ? 138 ASN L OD1 1 
ATOM   2666 N ND2 . ASN B 2 134 ? -14.528 -22.866 52.909  1.00 44.50 ? 138 ASN L ND2 1 
ATOM   2667 N N   . PHE B 2 135 ? -17.821 -24.938 48.840  1.00 33.35 ? 139 PHE L N   1 
ATOM   2668 C CA  . PHE B 2 135 ? -18.100 -26.084 47.986  1.00 30.91 ? 139 PHE L CA  1 
ATOM   2669 C C   . PHE B 2 135 ? -17.172 -26.078 46.773  1.00 33.92 ? 139 PHE L C   1 
ATOM   2670 O O   . PHE B 2 135 ? -16.435 -25.117 46.513  1.00 28.80 ? 139 PHE L O   1 
ATOM   2671 C CB  . PHE B 2 135 ? -19.563 -26.108 47.520  1.00 30.37 ? 139 PHE L CB  1 
ATOM   2672 C CG  . PHE B 2 135 ? -19.938 -24.938 46.633  1.00 37.35 ? 139 PHE L CG  1 
ATOM   2673 C CD1 . PHE B 2 135 ? -20.388 -23.744 47.189  1.00 31.25 ? 139 PHE L CD1 1 
ATOM   2674 C CD2 . PHE B 2 135 ? -19.852 -25.032 45.248  1.00 33.78 ? 139 PHE L CD2 1 
ATOM   2675 C CE1 . PHE B 2 135 ? -20.737 -22.660 46.378  1.00 29.31 ? 139 PHE L CE1 1 
ATOM   2676 C CE2 . PHE B 2 135 ? -20.195 -23.947 44.436  1.00 39.77 ? 139 PHE L CE2 1 
ATOM   2677 C CZ  . PHE B 2 135 ? -20.644 -22.756 45.010  1.00 27.07 ? 139 PHE L CZ  1 
ATOM   2678 N N   . TYR B 2 136 ? -17.245 -27.185 46.017  1.00 28.16 ? 140 TYR L N   1 
ATOM   2679 C CA  . TYR B 2 136 ? -16.417 -27.476 44.850  1.00 34.03 ? 140 TYR L CA  1 
ATOM   2680 C C   . TYR B 2 136 ? -17.027 -28.644 44.089  1.00 39.67 ? 140 TYR L C   1 
ATOM   2681 O O   . TYR B 2 136 ? -17.513 -29.603 44.705  1.00 40.69 ? 140 TYR L O   1 
ATOM   2682 C CB  . TYR B 2 136 ? -14.986 -27.810 45.252  1.00 34.38 ? 140 TYR L CB  1 
ATOM   2683 C CG  . TYR B 2 136 ? -14.036 -27.859 44.083  1.00 36.60 ? 140 TYR L CG  1 
ATOM   2684 C CD1 . TYR B 2 136 ? -13.850 -29.030 43.366  1.00 38.74 ? 140 TYR L CD1 1 
ATOM   2685 C CD2 . TYR B 2 136 ? -13.325 -26.732 43.696  1.00 34.10 ? 140 TYR L CD2 1 
ATOM   2686 C CE1 . TYR B 2 136 ? -12.983 -29.074 42.285  1.00 39.47 ? 140 TYR L CE1 1 
ATOM   2687 C CE2 . TYR B 2 136 ? -12.451 -26.765 42.622  1.00 36.82 ? 140 TYR L CE2 1 
ATOM   2688 C CZ  . TYR B 2 136 ? -12.282 -27.940 41.925  1.00 41.46 ? 140 TYR L CZ  1 
ATOM   2689 O OH  . TYR B 2 136 ? -11.424 -27.985 40.854  1.00 42.59 ? 140 TYR L OH  1 
ATOM   2690 N N   . PRO B 2 137 ? -17.050 -28.599 42.761  1.00 41.72 ? 141 PRO L N   1 
ATOM   2691 C CA  . PRO B 2 137 ? -16.543 -27.543 41.877  1.00 43.70 ? 141 PRO L CA  1 
ATOM   2692 C C   . PRO B 2 137 ? -17.458 -26.325 41.865  1.00 40.48 ? 141 PRO L C   1 
ATOM   2693 O O   . PRO B 2 137 ? -18.453 -26.268 42.573  1.00 38.21 ? 141 PRO L O   1 
ATOM   2694 C CB  . PRO B 2 137 ? -16.515 -28.242 40.515  1.00 40.26 ? 141 PRO L CB  1 
ATOM   2695 C CG  . PRO B 2 137 ? -17.763 -29.093 40.560  1.00 39.58 ? 141 PRO L CG  1 
ATOM   2696 C CD  . PRO B 2 137 ? -17.825 -29.600 42.000  1.00 41.69 ? 141 PRO L CD  1 
ATOM   2697 N N   . ARG B 2 138 ? -17.116 -25.354 41.021  1.00 46.04 ? 142 ARG L N   1 
ATOM   2698 C CA  . ARG B 2 138 ? -17.866 -24.111 40.941  1.00 38.59 ? 142 ARG L CA  1 
ATOM   2699 C C   . ARG B 2 138 ? -19.323 -24.345 40.567  1.00 41.37 ? 142 ARG L C   1 
ATOM   2700 O O   . ARG B 2 138 ? -20.210 -23.633 41.049  1.00 43.38 ? 142 ARG L O   1 
ATOM   2701 C CB  . ARG B 2 138 ? -17.184 -23.197 39.928  1.00 47.02 ? 142 ARG L CB  1 
ATOM   2702 C CG  . ARG B 2 138 ? -17.602 -21.755 39.988  1.00 45.03 ? 142 ARG L CG  1 
ATOM   2703 C CD  . ARG B 2 138 ? -16.721 -20.923 39.069  1.00 47.94 ? 142 ARG L CD  1 
ATOM   2704 N NE  . ARG B 2 138 ? -16.999 -19.503 39.215  1.00 51.87 ? 142 ARG L NE  1 
ATOM   2705 C CZ  . ARG B 2 138 ? -18.073 -18.907 38.717  1.00 47.20 ? 142 ARG L CZ  1 
ATOM   2706 N NH1 . ARG B 2 138 ? -18.968 -19.579 38.013  1.00 43.13 ? 142 ARG L NH1 1 
ATOM   2707 N NH2 . ARG B 2 138 ? -18.252 -17.607 38.931  1.00 48.14 ? 142 ARG L NH2 1 
ATOM   2708 N N   . GLU B 2 139 ? -19.599 -25.348 39.749  1.00 42.38 ? 143 GLU L N   1 
ATOM   2709 C CA  . GLU B 2 139 ? -20.937 -25.506 39.193  1.00 41.99 ? 143 GLU L CA  1 
ATOM   2710 C C   . GLU B 2 139 ? -21.899 -26.045 40.244  1.00 44.37 ? 143 GLU L C   1 
ATOM   2711 O O   . GLU B 2 139 ? -21.723 -27.164 40.738  1.00 42.16 ? 143 GLU L O   1 
ATOM   2712 C CB  . GLU B 2 139 ? -20.900 -26.434 37.981  1.00 44.85 ? 143 GLU L CB  1 
ATOM   2713 C CG  . GLU B 2 139 ? -19.823 -26.071 36.956  1.00 50.95 ? 143 GLU L CG  1 
ATOM   2714 C CD  . GLU B 2 139 ? -18.467 -26.715 37.262  1.00 54.23 ? 143 GLU L CD  1 
ATOM   2715 O OE1 . GLU B 2 139 ? -18.338 -27.956 37.128  1.00 57.89 ? 143 GLU L OE1 1 
ATOM   2716 O OE2 . GLU B 2 139 ? -17.528 -25.980 37.638  1.00 51.64 ? 143 GLU L OE2 1 
ATOM   2717 N N   . ALA B 2 140 ? -22.917 -25.247 40.577  1.00 39.42 ? 144 ALA L N   1 
ATOM   2718 C CA  . ALA B 2 140 ? -24.041 -25.682 41.400  1.00 35.02 ? 144 ALA L CA  1 
ATOM   2719 C C   . ALA B 2 140 ? -25.301 -24.955 40.948  1.00 38.65 ? 144 ALA L C   1 
ATOM   2720 O O   . ALA B 2 140 ? -25.244 -23.812 40.484  1.00 39.50 ? 144 ALA L O   1 
ATOM   2721 C CB  . ALA B 2 140 ? -23.800 -25.431 42.888  1.00 40.31 ? 144 ALA L CB  1 
ATOM   2722 N N   . LYS B 2 141 ? -26.441 -25.626 41.079  1.00 31.77 ? 145 LYS L N   1 
ATOM   2723 C CA  . LYS B 2 141 ? -27.720 -25.093 40.619  1.00 35.49 ? 145 LYS L CA  1 
ATOM   2724 C C   . LYS B 2 141 ? -28.468 -24.578 41.839  1.00 36.11 ? 145 LYS L C   1 
ATOM   2725 O O   . LYS B 2 141 ? -28.809 -25.350 42.740  1.00 33.45 ? 145 LYS L O   1 
ATOM   2726 C CB  . LYS B 2 141 ? -28.529 -26.157 39.886  1.00 33.05 ? 145 LYS L CB  1 
ATOM   2727 C CG  . LYS B 2 141 ? -29.877 -25.681 39.355  1.00 42.15 ? 145 LYS L CG  1 
ATOM   2728 C CD  . LYS B 2 141 ? -30.457 -26.694 38.366  1.00 39.74 ? 145 LYS L CD  1 
ATOM   2729 C CE  . LYS B 2 141 ? -31.604 -26.115 37.537  1.00 53.09 ? 145 LYS L CE  1 
ATOM   2730 N NZ  . LYS B 2 141 ? -32.071 -27.060 36.456  1.00 57.58 ? 145 LYS L NZ  1 
ATOM   2731 N N   . VAL B 2 142 ? -28.676 -23.274 41.894  1.00 31.39 ? 146 VAL L N   1 
ATOM   2732 C CA  . VAL B 2 142 ? -29.369 -22.639 43.005  1.00 30.42 ? 146 VAL L CA  1 
ATOM   2733 C C   . VAL B 2 142 ? -30.730 -22.234 42.479  1.00 36.64 ? 146 VAL L C   1 
ATOM   2734 O O   . VAL B 2 142 ? -30.821 -21.540 41.462  1.00 40.76 ? 146 VAL L O   1 
ATOM   2735 C CB  . VAL B 2 142 ? -28.589 -21.433 43.557  1.00 30.19 ? 146 VAL L CB  1 
ATOM   2736 C CG1 . VAL B 2 142 ? -29.361 -20.742 44.670  1.00 33.91 ? 146 VAL L CG1 1 
ATOM   2737 C CG2 . VAL B 2 142 ? -27.214 -21.864 44.066  1.00 32.67 ? 146 VAL L CG2 1 
ATOM   2738 N N   . GLN B 2 143 ? -31.792 -22.704 43.126  1.00 31.39 ? 147 GLN L N   1 
ATOM   2739 C CA  . GLN B 2 143 ? -33.131 -22.286 42.748  1.00 32.34 ? 147 GLN L CA  1 
ATOM   2740 C C   . GLN B 2 143 ? -33.859 -21.747 43.965  1.00 34.02 ? 147 GLN L C   1 
ATOM   2741 O O   . GLN B 2 143 ? -33.652 -22.213 45.089  1.00 34.46 ? 147 GLN L O   1 
ATOM   2742 C CB  . GLN B 2 143 ? -33.934 -23.428 42.137  1.00 27.00 ? 147 GLN L CB  1 
ATOM   2743 C CG  . GLN B 2 143 ? -33.317 -23.983 40.869  1.00 39.62 ? 147 GLN L CG  1 
ATOM   2744 C CD  . GLN B 2 143 ? -34.197 -25.038 40.242  1.00 46.44 ? 147 GLN L CD  1 
ATOM   2745 O OE1 . GLN B 2 143 ? -34.440 -26.094 40.837  1.00 53.52 ? 147 GLN L OE1 1 
ATOM   2746 N NE2 . GLN B 2 143 ? -34.708 -24.751 39.049  1.00 44.81 ? 147 GLN L NE2 1 
ATOM   2747 N N   . TRP B 2 144 ? -34.708 -20.754 43.730  1.00 26.30 ? 148 TRP L N   1 
ATOM   2748 C CA  . TRP B 2 144 ? -35.599 -20.220 44.748  1.00 26.16 ? 148 TRP L CA  1 
ATOM   2749 C C   . TRP B 2 144 ? -36.999 -20.757 44.505  1.00 32.20 ? 148 TRP L C   1 
ATOM   2750 O O   . TRP B 2 144 ? -37.454 -20.840 43.359  1.00 32.05 ? 148 TRP L O   1 
ATOM   2751 C CB  . TRP B 2 144 ? -35.615 -18.687 44.728  1.00 26.90 ? 148 TRP L CB  1 
ATOM   2752 C CG  . TRP B 2 144 ? -34.403 -18.062 45.349  1.00 27.36 ? 148 TRP L CG  1 
ATOM   2753 C CD1 . TRP B 2 144 ? -33.303 -17.553 44.696  1.00 27.23 ? 148 TRP L CD1 1 
ATOM   2754 C CD2 . TRP B 2 144 ? -34.157 -17.881 46.749  1.00 27.59 ? 148 TRP L CD2 1 
ATOM   2755 N NE1 . TRP B 2 144 ? -32.391 -17.069 45.607  1.00 29.19 ? 148 TRP L NE1 1 
ATOM   2756 C CE2 . TRP B 2 144 ? -32.886 -17.263 46.874  1.00 27.87 ? 148 TRP L CE2 1 
ATOM   2757 C CE3 . TRP B 2 144 ? -34.874 -18.202 47.913  1.00 28.41 ? 148 TRP L CE3 1 
ATOM   2758 C CZ2 . TRP B 2 144 ? -32.335 -16.947 48.102  1.00 23.21 ? 148 TRP L CZ2 1 
ATOM   2759 C CZ3 . TRP B 2 144 ? -34.315 -17.876 49.145  1.00 25.19 ? 148 TRP L CZ3 1 
ATOM   2760 C CH2 . TRP B 2 144 ? -33.063 -17.260 49.225  1.00 23.51 ? 148 TRP L CH2 1 
ATOM   2761 N N   . LYS B 2 145 ? -37.673 -21.140 45.590  1.00 30.29 ? 149 LYS L N   1 
ATOM   2762 C CA  . LYS B 2 145 ? -39.046 -21.609 45.537  1.00 30.35 ? 149 LYS L CA  1 
ATOM   2763 C C   . LYS B 2 145 ? -39.814 -20.934 46.660  1.00 32.14 ? 149 LYS L C   1 
ATOM   2764 O O   . LYS B 2 145 ? -39.338 -20.900 47.801  1.00 32.64 ? 149 LYS L O   1 
ATOM   2765 C CB  . LYS B 2 145 ? -39.119 -23.137 45.683  1.00 32.77 ? 149 LYS L CB  1 
ATOM   2766 C CG  . LYS B 2 145 ? -38.427 -23.918 44.556  1.00 32.90 ? 149 LYS L CG  1 
ATOM   2767 C CD  . LYS B 2 145 ? -38.502 -25.437 44.804  1.00 44.79 ? 149 LYS L CD  1 
ATOM   2768 C CE  . LYS B 2 145 ? -38.021 -26.231 43.590  1.00 45.87 ? 149 LYS L CE  1 
ATOM   2769 N NZ  . LYS B 2 145 ? -37.867 -27.691 43.877  1.00 50.02 ? 149 LYS L NZ  1 
ATOM   2770 N N   . VAL B 2 146 ? -40.981 -20.380 46.353  1.00 31.12 ? 150 VAL L N   1 
ATOM   2771 C CA  . VAL B 2 146 ? -41.831 -19.805 47.389  1.00 29.73 ? 150 VAL L CA  1 
ATOM   2772 C C   . VAL B 2 146 ? -43.165 -20.520 47.338  1.00 31.58 ? 150 VAL L C   1 
ATOM   2773 O O   . VAL B 2 146 ? -43.770 -20.662 46.265  1.00 31.51 ? 150 VAL L O   1 
ATOM   2774 C CB  . VAL B 2 146 ? -41.978 -18.269 47.281  1.00 29.17 ? 150 VAL L CB  1 
ATOM   2775 C CG1 . VAL B 2 146 ? -40.799 -17.641 46.546  1.00 29.43 ? 150 VAL L CG1 1 
ATOM   2776 C CG2 . VAL B 2 146 ? -43.312 -17.830 46.730  1.00 36.72 ? 150 VAL L CG2 1 
ATOM   2777 N N   . ASP B 2 147 ? -43.592 -21.011 48.501  1.00 31.72 ? 151 ASP L N   1 
ATOM   2778 C CA  . ASP B 2 147 ? -44.685 -21.958 48.584  1.00 31.31 ? 151 ASP L CA  1 
ATOM   2779 C C   . ASP B 2 147 ? -44.517 -23.037 47.517  1.00 31.08 ? 151 ASP L C   1 
ATOM   2780 O O   . ASP B 2 147 ? -45.450 -23.386 46.796  1.00 31.15 ? 151 ASP L O   1 
ATOM   2781 C CB  . ASP B 2 147 ? -46.029 -21.231 48.483  1.00 33.66 ? 151 ASP L CB  1 
ATOM   2782 C CG  . ASP B 2 147 ? -46.299 -20.342 49.704  1.00 34.88 ? 151 ASP L CG  1 
ATOM   2783 O OD1 . ASP B 2 147 ? -45.706 -20.604 50.781  1.00 36.00 ? 151 ASP L OD1 1 
ATOM   2784 O OD2 . ASP B 2 147 ? -47.110 -19.391 49.595  1.00 40.11 ? 151 ASP L OD2 1 
ATOM   2785 N N   . ASN B 2 148 ? -43.278 -23.512 47.379  1.00 27.38 ? 152 ASN L N   1 
ATOM   2786 C CA  . ASN B 2 148 ? -42.877 -24.610 46.503  1.00 33.98 ? 152 ASN L CA  1 
ATOM   2787 C C   . ASN B 2 148 ? -42.953 -24.277 45.009  1.00 38.31 ? 152 ASN L C   1 
ATOM   2788 O O   . ASN B 2 148 ? -42.862 -25.188 44.183  1.00 38.48 ? 152 ASN L O   1 
ATOM   2789 C CB  . ASN B 2 148 ? -43.700 -25.876 46.793  1.00 33.71 ? 152 ASN L CB  1 
ATOM   2790 C CG  . ASN B 2 148 ? -43.001 -27.147 46.328  1.00 49.05 ? 152 ASN L CG  1 
ATOM   2791 O OD1 . ASN B 2 148 ? -41.768 -27.251 46.389  1.00 46.79 ? 152 ASN L OD1 1 
ATOM   2792 N ND2 . ASN B 2 148 ? -43.784 -28.114 45.838  1.00 45.79 ? 152 ASN L ND2 1 
ATOM   2793 N N   . ALA B 2 149 ? -43.117 -23.012 44.620  1.00 35.26 ? 153 ALA L N   1 
ATOM   2794 C CA  . ALA B 2 149 ? -43.161 -22.652 43.202  1.00 35.70 ? 153 ALA L CA  1 
ATOM   2795 C C   . ALA B 2 149 ? -41.838 -22.026 42.781  1.00 32.87 ? 153 ALA L C   1 
ATOM   2796 O O   . ALA B 2 149 ? -41.328 -21.128 43.465  1.00 28.91 ? 153 ALA L O   1 
ATOM   2797 C CB  . ALA B 2 149 ? -44.311 -21.686 42.908  1.00 31.09 ? 153 ALA L CB  1 
ATOM   2798 N N   . LEU B 2 150 ? -41.294 -22.485 41.648  1.00 29.37 ? 154 LEU L N   1 
ATOM   2799 C CA  . LEU B 2 150 ? -40.025 -21.948 41.172  1.00 31.88 ? 154 LEU L CA  1 
ATOM   2800 C C   . LEU B 2 150 ? -40.164 -20.475 40.782  1.00 33.12 ? 154 LEU L C   1 
ATOM   2801 O O   . LEU B 2 150 ? -41.125 -20.082 40.110  1.00 29.89 ? 154 LEU L O   1 
ATOM   2802 C CB  . LEU B 2 150 ? -39.508 -22.760 39.984  1.00 34.25 ? 154 LEU L CB  1 
ATOM   2803 C CG  . LEU B 2 150 ? -38.116 -22.321 39.492  1.00 39.36 ? 154 LEU L CG  1 
ATOM   2804 C CD1 . LEU B 2 150 ? -37.076 -22.473 40.627  1.00 40.23 ? 154 LEU L CD1 1 
ATOM   2805 C CD2 . LEU B 2 150 ? -37.660 -23.051 38.205  1.00 40.20 ? 154 LEU L CD2 1 
ATOM   2806 N N   . GLN B 2 151 ? -39.175 -19.666 41.181  1.00 34.09 ? 155 GLN L N   1 
ATOM   2807 C CA  . GLN B 2 151 ? -39.237 -18.212 41.006  1.00 39.41 ? 155 GLN L CA  1 
ATOM   2808 C C   . GLN B 2 151 ? -38.624 -17.726 39.698  1.00 39.11 ? 155 GLN L C   1 
ATOM   2809 O O   . GLN B 2 151 ? -39.280 -16.996 38.953  1.00 46.11 ? 155 GLN L O   1 
ATOM   2810 C CB  . GLN B 2 151 ? -38.563 -17.501 42.179  1.00 30.39 ? 155 GLN L CB  1 
ATOM   2811 C CG  . GLN B 2 151 ? -39.399 -17.559 43.424  1.00 30.66 ? 155 GLN L CG  1 
ATOM   2812 C CD  . GLN B 2 151 ? -40.845 -17.190 43.147  1.00 33.79 ? 155 GLN L CD  1 
ATOM   2813 O OE1 . GLN B 2 151 ? -41.169 -16.017 42.992  1.00 35.94 ? 155 GLN L OE1 1 
ATOM   2814 N NE2 . GLN B 2 151 ? -41.725 -18.196 43.080  1.00 28.65 ? 155 GLN L NE2 1 
ATOM   2815 N N   . SER B 2 152 ? -37.356 -18.039 39.443  1.00 43.22 ? 156 SER L N   1 
ATOM   2816 C CA  . SER B 2 152 ? -36.772 -17.766 38.127  1.00 55.70 ? 156 SER L CA  1 
ATOM   2817 C C   . SER B 2 152 ? -37.133 -16.391 37.540  1.00 48.61 ? 156 SER L C   1 
ATOM   2818 O O   . SER B 2 152 ? -37.980 -16.310 36.639  1.00 47.56 ? 156 SER L O   1 
ATOM   2819 C CB  . SER B 2 152 ? -37.137 -18.888 37.148  1.00 61.36 ? 156 SER L CB  1 
ATOM   2820 O OG  . SER B 2 152 ? -36.350 -20.052 37.398  1.00 53.82 ? 156 SER L OG  1 
ATOM   2821 N N   . GLY B 2 153 ? -36.535 -15.314 38.071  1.00 43.45 ? 157 GLY L N   1 
ATOM   2822 C CA  . GLY B 2 153 ? -36.733 -13.965 37.567  1.00 35.61 ? 157 GLY L CA  1 
ATOM   2823 C C   . GLY B 2 153 ? -36.592 -12.816 38.561  1.00 43.85 ? 157 GLY L C   1 
ATOM   2824 O O   . GLY B 2 153 ? -36.599 -11.648 38.159  1.00 39.11 ? 157 GLY L O   1 
ATOM   2825 N N   . ASN B 2 154 ? -36.437 -13.106 39.857  1.00 38.19 ? 158 ASN L N   1 
ATOM   2826 C CA  . ASN B 2 154 ? -36.377 -12.058 40.876  1.00 32.50 ? 158 ASN L CA  1 
ATOM   2827 C C   . ASN B 2 154 ? -35.221 -12.283 41.855  1.00 33.96 ? 158 ASN L C   1 
ATOM   2828 O O   . ASN B 2 154 ? -35.303 -11.899 43.028  1.00 29.29 ? 158 ASN L O   1 
ATOM   2829 C CB  . ASN B 2 154 ? -37.708 -11.967 41.620  1.00 33.05 ? 158 ASN L CB  1 
ATOM   2830 C CG  . ASN B 2 154 ? -38.260 -13.341 41.974  1.00 37.55 ? 158 ASN L CG  1 
ATOM   2831 O OD1 . ASN B 2 154 ? -37.544 -14.347 41.879  1.00 34.40 ? 158 ASN L OD1 1 
ATOM   2832 N ND2 . ASN B 2 154 ? -39.533 -13.396 42.375  1.00 40.04 ? 158 ASN L ND2 1 
ATOM   2833 N N   . SER B 2 155 ? -34.133 -12.895 41.387  1.00 27.04 ? 159 SER L N   1 
ATOM   2834 C CA  . SER B 2 155 ? -33.000 -13.228 42.235  1.00 27.26 ? 159 SER L CA  1 
ATOM   2835 C C   . SER B 2 155 ? -31.709 -13.031 41.457  1.00 25.21 ? 159 SER L C   1 
ATOM   2836 O O   . SER B 2 155 ? -31.688 -13.088 40.227  1.00 26.48 ? 159 SER L O   1 
ATOM   2837 C CB  . SER B 2 155 ? -33.083 -14.678 42.737  1.00 26.59 ? 159 SER L CB  1 
ATOM   2838 O OG  . SER B 2 155 ? -32.895 -15.597 41.667  1.00 29.78 ? 159 SER L OG  1 
ATOM   2839 N N   . GLN B 2 156 ? -30.620 -12.822 42.191  1.00 24.65 ? 160 GLN L N   1 
ATOM   2840 C CA  . GLN B 2 156 ? -29.291 -12.725 41.605  1.00 27.49 ? 160 GLN L CA  1 
ATOM   2841 C C   . GLN B 2 156 ? -28.279 -13.360 42.552  1.00 31.21 ? 160 GLN L C   1 
ATOM   2842 O O   . GLN B 2 156 ? -28.453 -13.336 43.778  1.00 25.19 ? 160 GLN L O   1 
ATOM   2843 C CB  . GLN B 2 156 ? -28.873 -11.271 41.349  1.00 29.10 ? 160 GLN L CB  1 
ATOM   2844 C CG  . GLN B 2 156 ? -29.737 -10.529 40.351  1.00 32.01 ? 160 GLN L CG  1 
ATOM   2845 C CD  . GLN B 2 156 ? -29.370 -9.055  40.225  1.00 33.95 ? 160 GLN L CD  1 
ATOM   2846 O OE1 . GLN B 2 156 ? -29.689 -8.232  41.098  1.00 33.44 ? 160 GLN L OE1 1 
ATOM   2847 N NE2 . GLN B 2 156 ? -28.716 -8.713  39.131  1.00 30.49 ? 160 GLN L NE2 1 
ATOM   2848 N N   . GLU B 2 157 ? -27.180 -13.857 41.975  1.00 24.46 ? 161 GLU L N   1 
ATOM   2849 C CA  . GLU B 2 157 ? -26.149 -14.595 42.698  1.00 28.03 ? 161 GLU L CA  1 
ATOM   2850 C C   . GLU B 2 157 ? -24.764 -14.080 42.342  1.00 27.26 ? 161 GLU L C   1 
ATOM   2851 O O   . GLU B 2 157 ? -24.548 -13.510 41.272  1.00 25.73 ? 161 GLU L O   1 
ATOM   2852 C CB  . GLU B 2 157 ? -26.213 -16.088 42.369  1.00 26.46 ? 161 GLU L CB  1 
ATOM   2853 C CG  . GLU B 2 157 ? -27.571 -16.485 41.872  1.00 39.37 ? 161 GLU L CG  1 
ATOM   2854 C CD  . GLU B 2 157 ? -27.820 -17.981 41.909  1.00 45.56 ? 161 GLU L CD  1 
ATOM   2855 O OE1 . GLU B 2 157 ? -26.912 -18.741 41.460  1.00 34.85 ? 161 GLU L OE1 1 
ATOM   2856 O OE2 . GLU B 2 157 ? -28.935 -18.359 42.383  1.00 38.31 ? 161 GLU L OE2 1 
ATOM   2857 N N   . SER B 2 158 ? -23.814 -14.303 43.256  1.00 23.23 ? 162 SER L N   1 
ATOM   2858 C CA  . SER B 2 158 ? -22.407 -14.109 42.951  1.00 27.35 ? 162 SER L CA  1 
ATOM   2859 C C   . SER B 2 158 ? -21.602 -15.129 43.738  1.00 27.60 ? 162 SER L C   1 
ATOM   2860 O O   . SER B 2 158 ? -22.073 -15.719 44.714  1.00 23.77 ? 162 SER L O   1 
ATOM   2861 C CB  . SER B 2 158 ? -21.900 -12.681 43.241  1.00 24.99 ? 162 SER L CB  1 
ATOM   2862 O OG  . SER B 2 158 ? -21.930 -12.367 44.629  1.00 28.73 ? 162 SER L OG  1 
ATOM   2863 N N   . VAL B 2 159 ? -20.377 -15.335 43.284  1.00 27.02 ? 163 VAL L N   1 
ATOM   2864 C CA  . VAL B 2 159 ? -19.533 -16.420 43.745  1.00 28.37 ? 163 VAL L CA  1 
ATOM   2865 C C   . VAL B 2 159 ? -18.180 -15.821 44.043  1.00 28.01 ? 163 VAL L C   1 
ATOM   2866 O O   . VAL B 2 159 ? -17.676 -15.022 43.251  1.00 32.50 ? 163 VAL L O   1 
ATOM   2867 C CB  . VAL B 2 159 ? -19.416 -17.532 42.683  1.00 30.24 ? 163 VAL L CB  1 
ATOM   2868 C CG1 . VAL B 2 159 ? -18.556 -18.680 43.193  1.00 29.68 ? 163 VAL L CG1 1 
ATOM   2869 C CG2 . VAL B 2 159 ? -20.778 -18.036 42.299  1.00 29.24 ? 163 VAL L CG2 1 
ATOM   2870 N N   . THR B 2 160 ? -17.597 -16.187 45.178  1.00 30.28 ? 164 THR L N   1 
ATOM   2871 C CA  . THR B 2 160 ? -16.246 -15.724 45.464  1.00 31.13 ? 164 THR L CA  1 
ATOM   2872 C C   . THR B 2 160 ? -15.230 -16.397 44.537  1.00 37.12 ? 164 THR L C   1 
ATOM   2873 O O   . THR B 2 160 ? -15.530 -17.367 43.829  1.00 34.15 ? 164 THR L O   1 
ATOM   2874 C CB  . THR B 2 160 ? -15.855 -16.036 46.902  1.00 31.83 ? 164 THR L CB  1 
ATOM   2875 O OG1 . THR B 2 160 ? -16.050 -17.436 47.137  1.00 32.38 ? 164 THR L OG1 1 
ATOM   2876 C CG2 . THR B 2 160 ? -16.686 -15.208 47.881  1.00 32.00 ? 164 THR L CG2 1 
ATOM   2877 N N   . GLU B 2 161 ? -14.003 -15.873 44.564  1.00 30.16 ? 165 GLU L N   1 
ATOM   2878 C CA  . GLU B 2 161 ? -12.869 -16.561 43.960  1.00 35.52 ? 165 GLU L CA  1 
ATOM   2879 C C   . GLU B 2 161 ? -12.432 -17.709 44.871  1.00 38.31 ? 165 GLU L C   1 
ATOM   2880 O O   . GLU B 2 161 ? -12.787 -17.761 46.053  1.00 35.55 ? 165 GLU L O   1 
ATOM   2881 C CB  . GLU B 2 161 ? -11.701 -15.600 43.734  1.00 36.07 ? 165 GLU L CB  1 
ATOM   2882 C CG  . GLU B 2 161 ? -12.008 -14.387 42.845  1.00 40.64 ? 165 GLU L CG  1 
ATOM   2883 C CD  . GLU B 2 161 ? -11.916 -14.708 41.360  1.00 49.47 ? 165 GLU L CD  1 
ATOM   2884 O OE1 . GLU B 2 161 ? -12.471 -13.944 40.541  1.00 60.00 ? 165 GLU L OE1 1 
ATOM   2885 O OE2 . GLU B 2 161 ? -11.281 -15.723 41.004  1.00 46.84 ? 165 GLU L OE2 1 
ATOM   2886 N N   . GLN B 2 162 ? -11.670 -18.645 44.305  1.00 37.44 ? 166 GLN L N   1 
ATOM   2887 C CA  . GLN B 2 162 ? -11.265 -19.824 45.057  1.00 37.64 ? 166 GLN L CA  1 
ATOM   2888 C C   . GLN B 2 162 ? -10.575 -19.398 46.338  1.00 39.37 ? 166 GLN L C   1 
ATOM   2889 O O   . GLN B 2 162 ? -9.681  -18.545 46.325  1.00 33.32 ? 166 GLN L O   1 
ATOM   2890 C CB  . GLN B 2 162 ? -10.330 -20.719 44.230  1.00 34.38 ? 166 GLN L CB  1 
ATOM   2891 C CG  . GLN B 2 162 ? -11.055 -21.656 43.289  1.00 37.25 ? 166 GLN L CG  1 
ATOM   2892 C CD  . GLN B 2 162 ? -10.147 -22.698 42.649  1.00 42.08 ? 166 GLN L CD  1 
ATOM   2893 O OE1 . GLN B 2 162 ? -9.310  -22.379 41.791  1.00 37.34 ? 166 GLN L OE1 1 
ATOM   2894 N NE2 . GLN B 2 162 ? -10.315 -23.963 43.062  1.00 32.06 ? 166 GLN L NE2 1 
ATOM   2895 N N   . ASP B 2 163 ? -11.012 -19.995 47.445  1.00 34.64 ? 167 ASP L N   1 
ATOM   2896 C CA  . ASP B 2 163 ? -10.499 -19.634 48.758  1.00 39.60 ? 167 ASP L CA  1 
ATOM   2897 C C   . ASP B 2 163 ? -8.997  -19.902 48.845  1.00 43.90 ? 167 ASP L C   1 
ATOM   2898 O O   . ASP B 2 163 ? -8.497  -20.930 48.376  1.00 41.30 ? 167 ASP L O   1 
ATOM   2899 C CB  . ASP B 2 163 ? -11.264 -20.424 49.820  1.00 43.61 ? 167 ASP L CB  1 
ATOM   2900 C CG  . ASP B 2 163 ? -11.071 -19.878 51.225  1.00 50.90 ? 167 ASP L CG  1 
ATOM   2901 O OD1 . ASP B 2 163 ? -11.746 -18.879 51.572  1.00 49.60 ? 167 ASP L OD1 1 
ATOM   2902 O OD2 . ASP B 2 163 ? -10.257 -20.460 51.979  1.00 46.66 ? 167 ASP L OD2 1 
ATOM   2903 N N   . SER B 2 164 ? -8.263  -18.953 49.429  1.00 47.88 ? 168 SER L N   1 
ATOM   2904 C CA  . SER B 2 164 ? -6.809  -19.076 49.488  1.00 42.58 ? 168 SER L CA  1 
ATOM   2905 C C   . SER B 2 164 ? -6.352  -20.246 50.345  1.00 49.85 ? 168 SER L C   1 
ATOM   2906 O O   . SER B 2 164 ? -5.226  -20.729 50.170  1.00 51.98 ? 168 SER L O   1 
ATOM   2907 C CB  . SER B 2 164 ? -6.196  -17.789 50.028  1.00 40.73 ? 168 SER L CB  1 
ATOM   2908 O OG  . SER B 2 164 ? -6.794  -17.435 51.259  1.00 54.74 ? 168 SER L OG  1 
ATOM   2909 N N   . LYS B 2 165 ? -7.198  -20.713 51.260  1.00 49.68 ? 169 LYS L N   1 
ATOM   2910 C CA  . LYS B 2 165 ? -6.827  -21.743 52.219  1.00 51.71 ? 169 LYS L CA  1 
ATOM   2911 C C   . LYS B 2 165 ? -7.233  -23.140 51.765  1.00 46.87 ? 169 LYS L C   1 
ATOM   2912 O O   . LYS B 2 165 ? -6.413  -24.059 51.819  1.00 51.69 ? 169 LYS L O   1 
ATOM   2913 C CB  . LYS B 2 165 ? -7.437  -21.419 53.591  1.00 49.79 ? 169 LYS L CB  1 
ATOM   2914 C CG  . LYS B 2 165 ? -6.778  -20.214 54.297  1.00 51.46 ? 169 LYS L CG  1 
ATOM   2915 C CD  . LYS B 2 165 ? -7.786  -19.143 54.757  1.00 60.33 ? 169 LYS L CD  1 
ATOM   2916 C CE  . LYS B 2 165 ? -8.495  -18.437 53.583  1.00 58.57 ? 169 LYS L CE  1 
ATOM   2917 N NZ  . LYS B 2 165 ? -9.567  -17.465 54.000  1.00 56.22 ? 169 LYS L NZ  1 
ATOM   2918 N N   . ASP B 2 166 ? -8.473  -23.318 51.297  1.00 45.69 ? 170 ASP L N   1 
ATOM   2919 C CA  . ASP B 2 166 ? -8.979  -24.639 50.948  1.00 42.90 ? 170 ASP L CA  1 
ATOM   2920 C C   . ASP B 2 166 ? -9.422  -24.761 49.497  1.00 41.22 ? 170 ASP L C   1 
ATOM   2921 O O   . ASP B 2 166 ? -9.963  -25.812 49.123  1.00 35.31 ? 170 ASP L O   1 
ATOM   2922 C CB  . ASP B 2 166 ? -10.140 -25.038 51.883  1.00 42.12 ? 170 ASP L CB  1 
ATOM   2923 C CG  . ASP B 2 166 ? -11.379 -24.148 51.721  1.00 47.42 ? 170 ASP L CG  1 
ATOM   2924 O OD1 . ASP B 2 166 ? -11.402 -23.278 50.825  1.00 44.60 ? 170 ASP L OD1 1 
ATOM   2925 O OD2 . ASP B 2 166 ? -12.363 -24.347 52.474  1.00 49.40 ? 170 ASP L OD2 1 
ATOM   2926 N N   . SER B 2 167 ? -9.235  -23.719 48.682  1.00 37.89 ? 171 SER L N   1 
ATOM   2927 C CA  . SER B 2 167 ? -9.557  -23.740 47.255  1.00 36.64 ? 171 SER L CA  1 
ATOM   2928 C C   . SER B 2 167 ? -11.032 -24.010 46.978  1.00 34.49 ? 171 SER L C   1 
ATOM   2929 O O   . SER B 2 167 ? -11.378 -24.467 45.887  1.00 34.51 ? 171 SER L O   1 
ATOM   2930 C CB  . SER B 2 167 ? -8.694  -24.768 46.501  1.00 35.69 ? 171 SER L CB  1 
ATOM   2931 O OG  . SER B 2 167 ? -7.336  -24.604 46.844  1.00 41.24 ? 171 SER L OG  1 
ATOM   2932 N N   . THR B 2 168 ? -11.923 -23.736 47.928  1.00 32.45 ? 172 THR L N   1 
ATOM   2933 C CA  . THR B 2 168 ? -13.346 -23.849 47.649  1.00 35.20 ? 172 THR L CA  1 
ATOM   2934 C C   . THR B 2 168 ? -13.924 -22.524 47.149  1.00 33.09 ? 172 THR L C   1 
ATOM   2935 O O   . THR B 2 168 ? -13.292 -21.470 47.198  1.00 32.28 ? 172 THR L O   1 
ATOM   2936 C CB  . THR B 2 168 ? -14.126 -24.292 48.890  1.00 31.39 ? 172 THR L CB  1 
ATOM   2937 O OG1 . THR B 2 168 ? -14.060 -23.260 49.889  1.00 33.12 ? 172 THR L OG1 1 
ATOM   2938 C CG2 . THR B 2 168 ? -13.562 -25.621 49.446  1.00 35.18 ? 172 THR L CG2 1 
ATOM   2939 N N   . TYR B 2 169 ? -15.154 -22.605 46.671  1.00 31.83 ? 173 TYR L N   1 
ATOM   2940 C CA  . TYR B 2 169 ? -15.980 -21.459 46.343  1.00 34.25 ? 173 TYR L CA  1 
ATOM   2941 C C   . TYR B 2 169 ? -17.031 -21.249 47.425  1.00 34.11 ? 173 TYR L C   1 
ATOM   2942 O O   . TYR B 2 169 ? -17.327 -22.143 48.224  1.00 30.07 ? 173 TYR L O   1 
ATOM   2943 C CB  . TYR B 2 169 ? -16.677 -21.662 44.996  1.00 32.12 ? 173 TYR L CB  1 
ATOM   2944 C CG  . TYR B 2 169 ? -15.715 -21.845 43.845  1.00 37.11 ? 173 TYR L CG  1 
ATOM   2945 C CD1 . TYR B 2 169 ? -15.084 -20.752 43.269  1.00 30.04 ? 173 TYR L CD1 1 
ATOM   2946 C CD2 . TYR B 2 169 ? -15.436 -23.112 43.336  1.00 37.06 ? 173 TYR L CD2 1 
ATOM   2947 C CE1 . TYR B 2 169 ? -14.206 -20.907 42.214  1.00 39.20 ? 173 TYR L CE1 1 
ATOM   2948 C CE2 . TYR B 2 169 ? -14.549 -23.283 42.272  1.00 36.42 ? 173 TYR L CE2 1 
ATOM   2949 C CZ  . TYR B 2 169 ? -13.935 -22.175 41.718  1.00 39.20 ? 173 TYR L CZ  1 
ATOM   2950 O OH  . TYR B 2 169 ? -13.045 -22.322 40.674  1.00 38.58 ? 173 TYR L OH  1 
ATOM   2951 N N   . SER B 2 170 ? -17.597 -20.042 47.431  1.00 29.43 ? 174 SER L N   1 
ATOM   2952 C CA  . SER B 2 170 ? -18.794 -19.739 48.193  1.00 26.87 ? 174 SER L CA  1 
ATOM   2953 C C   . SER B 2 170 ? -19.704 -18.901 47.317  1.00 30.06 ? 174 SER L C   1 
ATOM   2954 O O   . SER B 2 170 ? -19.243 -18.142 46.458  1.00 29.47 ? 174 SER L O   1 
ATOM   2955 C CB  . SER B 2 170 ? -18.486 -19.019 49.497  1.00 29.20 ? 174 SER L CB  1 
ATOM   2956 O OG  . SER B 2 170 ? -17.985 -19.930 50.458  1.00 27.88 ? 174 SER L OG  1 
ATOM   2957 N N   . LEU B 2 171 ? -21.006 -19.074 47.526  1.00 26.87 ? 175 LEU L N   1 
ATOM   2958 C CA  . LEU B 2 171 ? -22.020 -18.461 46.688  1.00 25.60 ? 175 LEU L CA  1 
ATOM   2959 C C   . LEU B 2 171 ? -23.084 -17.818 47.562  1.00 30.57 ? 175 LEU L C   1 
ATOM   2960 O O   . LEU B 2 171 ? -23.566 -18.423 48.536  1.00 27.89 ? 175 LEU L O   1 
ATOM   2961 C CB  . LEU B 2 171 ? -22.646 -19.492 45.741  1.00 25.47 ? 175 LEU L CB  1 
ATOM   2962 C CG  . LEU B 2 171 ? -23.677 -18.967 44.743  1.00 26.48 ? 175 LEU L CG  1 
ATOM   2963 C CD1 . LEU B 2 171 ? -23.718 -19.853 43.516  1.00 25.96 ? 175 LEU L CD1 1 
ATOM   2964 C CD2 . LEU B 2 171 ? -25.074 -18.921 45.393  1.00 26.93 ? 175 LEU L CD2 1 
ATOM   2965 N N   . SER B 2 172 ? -23.455 -16.594 47.190  1.00 26.30 ? 176 SER L N   1 
ATOM   2966 C CA  . SER B 2 172 ? -24.554 -15.857 47.791  1.00 24.99 ? 176 SER L CA  1 
ATOM   2967 C C   . SER B 2 172 ? -25.593 -15.622 46.714  1.00 26.96 ? 176 SER L C   1 
ATOM   2968 O O   . SER B 2 172 ? -25.244 -15.238 45.598  1.00 29.49 ? 176 SER L O   1 
ATOM   2969 C CB  . SER B 2 172 ? -24.075 -14.525 48.350  1.00 26.00 ? 176 SER L CB  1 
ATOM   2970 O OG  . SER B 2 172 ? -25.161 -13.813 48.893  1.00 26.88 ? 176 SER L OG  1 
ATOM   2971 N N   . SER B 2 173 ? -26.843 -15.891 47.029  1.00 26.34 ? 177 SER L N   1 
ATOM   2972 C CA  . SER B 2 173 ? -27.963 -15.598 46.150  1.00 27.65 ? 177 SER L CA  1 
ATOM   2973 C C   . SER B 2 173 ? -28.982 -14.809 46.953  1.00 30.08 ? 177 SER L C   1 
ATOM   2974 O O   . SER B 2 173 ? -29.236 -15.133 48.119  1.00 30.94 ? 177 SER L O   1 
ATOM   2975 C CB  . SER B 2 173 ? -28.603 -16.878 45.597  1.00 25.95 ? 177 SER L CB  1 
ATOM   2976 O OG  . SER B 2 173 ? -29.718 -16.575 44.777  1.00 28.97 ? 177 SER L OG  1 
ATOM   2977 N N   . THR B 2 174 ? -29.549 -13.764 46.340  1.00 25.05 ? 178 THR L N   1 
ATOM   2978 C CA  . THR B 2 174 ? -30.525 -12.899 46.995  1.00 29.11 ? 178 THR L CA  1 
ATOM   2979 C C   . THR B 2 174 ? -31.847 -12.931 46.237  1.00 27.97 ? 178 THR L C   1 
ATOM   2980 O O   . THR B 2 174 ? -31.892 -12.639 45.040  1.00 29.23 ? 178 THR L O   1 
ATOM   2981 C CB  . THR B 2 174 ? -30.015 -11.462 47.096  1.00 25.02 ? 178 THR L CB  1 
ATOM   2982 O OG1 . THR B 2 174 ? -28.733 -11.453 47.726  1.00 28.32 ? 178 THR L OG1 1 
ATOM   2983 C CG2 . THR B 2 174 ? -30.939 -10.665 47.952  1.00 23.32 ? 178 THR L CG2 1 
ATOM   2984 N N   . LEU B 2 175 ? -32.911 -13.317 46.926  1.00 28.15 ? 179 LEU L N   1 
ATOM   2985 C CA  . LEU B 2 175 ? -34.262 -13.196 46.411  1.00 24.61 ? 179 LEU L CA  1 
ATOM   2986 C C   . LEU B 2 175 ? -34.824 -11.876 46.910  1.00 27.82 ? 179 LEU L C   1 
ATOM   2987 O O   . LEU B 2 175 ? -34.773 -11.591 48.111  1.00 26.80 ? 179 LEU L O   1 
ATOM   2988 C CB  . LEU B 2 175 ? -35.132 -14.357 46.894  1.00 23.28 ? 179 LEU L CB  1 
ATOM   2989 C CG  . LEU B 2 175 ? -36.612 -14.369 46.521  1.00 34.00 ? 179 LEU L CG  1 
ATOM   2990 C CD1 . LEU B 2 175 ? -36.796 -14.715 45.023  1.00 33.29 ? 179 LEU L CD1 1 
ATOM   2991 C CD2 . LEU B 2 175 ? -37.404 -15.345 47.423  1.00 27.16 ? 179 LEU L CD2 1 
ATOM   2992 N N   . THR B 2 176 ? -35.338 -11.060 46.000  1.00 28.87 ? 180 THR L N   1 
ATOM   2993 C CA  . THR B 2 176 ? -35.863 -9.758  46.384  1.00 31.33 ? 180 THR L CA  1 
ATOM   2994 C C   . THR B 2 176 ? -37.311 -9.631  45.942  1.00 28.34 ? 180 THR L C   1 
ATOM   2995 O O   . THR B 2 176 ? -37.626 -9.810  44.760  1.00 32.17 ? 180 THR L O   1 
ATOM   2996 C CB  . THR B 2 176 ? -35.009 -8.636  45.806  1.00 33.47 ? 180 THR L CB  1 
ATOM   2997 O OG1 . THR B 2 176 ? -33.741 -8.658  46.465  1.00 33.01 ? 180 THR L OG1 1 
ATOM   2998 C CG2 . THR B 2 176 ? -35.684 -7.288  46.066  1.00 32.26 ? 180 THR L CG2 1 
ATOM   2999 N N   . LEU B 2 177 ? -38.191 -9.333  46.894  1.00 27.61 ? 181 LEU L N   1 
ATOM   3000 C CA  . LEU B 2 177 ? -39.611 -9.137  46.624  1.00 34.04 ? 181 LEU L CA  1 
ATOM   3001 C C   . LEU B 2 177 ? -40.094 -7.853  47.278  1.00 31.54 ? 181 LEU L C   1 
ATOM   3002 O O   . LEU B 2 177 ? -39.547 -7.410  48.291  1.00 30.53 ? 181 LEU L O   1 
ATOM   3003 C CB  . LEU B 2 177 ? -40.474 -10.275 47.175  1.00 36.31 ? 181 LEU L CB  1 
ATOM   3004 C CG  . LEU B 2 177 ? -40.343 -11.693 46.658  1.00 39.23 ? 181 LEU L CG  1 
ATOM   3005 C CD1 . LEU B 2 177 ? -41.358 -12.569 47.383  1.00 38.95 ? 181 LEU L CD1 1 
ATOM   3006 C CD2 . LEU B 2 177 ? -40.563 -11.713 45.145  1.00 41.27 ? 181 LEU L CD2 1 
ATOM   3007 N N   . SER B 2 178 ? -41.154 -7.280  46.721  1.00 32.94 ? 182 SER L N   1 
ATOM   3008 C CA  . SER B 2 178 ? -41.853 -6.227  47.439  1.00 29.97 ? 182 SER L CA  1 
ATOM   3009 C C   . SER B 2 178 ? -42.386 -6.791  48.748  1.00 34.09 ? 182 SER L C   1 
ATOM   3010 O O   . SER B 2 178 ? -42.728 -7.974  48.839  1.00 39.35 ? 182 SER L O   1 
ATOM   3011 C CB  . SER B 2 178 ? -43.012 -5.682  46.612  1.00 36.73 ? 182 SER L CB  1 
ATOM   3012 O OG  . SER B 2 178 ? -44.129 -6.549  46.685  1.00 36.58 ? 182 SER L OG  1 
ATOM   3013 N N   . LYS B 2 179 ? -42.444 -5.940  49.773  1.00 33.02 ? 183 LYS L N   1 
ATOM   3014 C CA  . LYS B 2 179 ? -43.007 -6.368  51.045  1.00 31.09 ? 183 LYS L CA  1 
ATOM   3015 C C   . LYS B 2 179 ? -44.393 -6.957  50.854  1.00 33.84 ? 183 LYS L C   1 
ATOM   3016 O O   . LYS B 2 179 ? -44.705 -8.015  51.410  1.00 33.54 ? 183 LYS L O   1 
ATOM   3017 C CB  . LYS B 2 179 ? -43.053 -5.200  52.028  1.00 34.81 ? 183 LYS L CB  1 
ATOM   3018 C CG  . LYS B 2 179 ? -43.735 -5.529  53.350  1.00 37.99 ? 183 LYS L CG  1 
ATOM   3019 C CD  . LYS B 2 179 ? -43.416 -4.448  54.370  1.00 43.17 ? 183 LYS L CD  1 
ATOM   3020 C CE  . LYS B 2 179 ? -44.662 -3.843  54.975  1.00 52.11 ? 183 LYS L CE  1 
ATOM   3021 N NZ  . LYS B 2 179 ? -45.020 -4.506  56.265  1.00 59.31 ? 183 LYS L NZ  1 
ATOM   3022 N N   . ALA B 2 180 ? -45.223 -6.307  50.036  1.00 35.56 ? 184 ALA L N   1 
ATOM   3023 C CA  . ALA B 2 180 ? -46.573 -6.809  49.790  1.00 41.35 ? 184 ALA L CA  1 
ATOM   3024 C C   . ALA B 2 180 ? -46.546 -8.248  49.259  1.00 40.71 ? 184 ALA L C   1 
ATOM   3025 O O   . ALA B 2 180 ? -47.290 -9.108  49.739  1.00 37.90 ? 184 ALA L O   1 
ATOM   3026 C CB  . ALA B 2 180 ? -47.307 -5.872  48.821  1.00 38.20 ? 184 ALA L CB  1 
ATOM   3027 N N   . ASP B 2 181 ? -45.674 -8.541  48.285  1.00 41.98 ? 185 ASP L N   1 
ATOM   3028 C CA  . ASP B 2 181 ? -45.600 -9.913  47.774  1.00 39.60 ? 185 ASP L CA  1 
ATOM   3029 C C   . ASP B 2 181 ? -45.006 -10.868 48.798  1.00 34.84 ? 185 ASP L C   1 
ATOM   3030 O O   . ASP B 2 181 ? -45.422 -12.028 48.879  1.00 33.74 ? 185 ASP L O   1 
ATOM   3031 C CB  . ASP B 2 181 ? -44.788 -9.963  46.486  1.00 36.69 ? 185 ASP L CB  1 
ATOM   3032 C CG  . ASP B 2 181 ? -45.521 -9.359  45.317  1.00 47.36 ? 185 ASP L CG  1 
ATOM   3033 O OD1 . ASP B 2 181 ? -46.658 -8.855  45.514  1.00 47.16 ? 185 ASP L OD1 1 
ATOM   3034 O OD2 . ASP B 2 181 ? -44.956 -9.386  44.199  1.00 44.90 ? 185 ASP L OD2 1 
ATOM   3035 N N   . TYR B 2 182 ? -44.040 -10.401 49.586  1.00 33.91 ? 186 TYR L N   1 
ATOM   3036 C CA  . TYR B 2 182 ? -43.423 -11.253 50.589  1.00 31.55 ? 186 TYR L CA  1 
ATOM   3037 C C   . TYR B 2 182 ? -44.441 -11.751 51.597  1.00 37.92 ? 186 TYR L C   1 
ATOM   3038 O O   . TYR B 2 182 ? -44.333 -12.880 52.088  1.00 35.79 ? 186 TYR L O   1 
ATOM   3039 C CB  . TYR B 2 182 ? -42.317 -10.487 51.296  1.00 33.75 ? 186 TYR L CB  1 
ATOM   3040 C CG  . TYR B 2 182 ? -41.644 -11.255 52.408  1.00 32.27 ? 186 TYR L CG  1 
ATOM   3041 C CD1 . TYR B 2 182 ? -40.845 -12.361 52.133  1.00 30.78 ? 186 TYR L CD1 1 
ATOM   3042 C CD2 . TYR B 2 182 ? -41.788 -10.857 53.728  1.00 31.44 ? 186 TYR L CD2 1 
ATOM   3043 C CE1 . TYR B 2 182 ? -40.206 -13.057 53.167  1.00 35.69 ? 186 TYR L CE1 1 
ATOM   3044 C CE2 . TYR B 2 182 ? -41.169 -11.527 54.753  1.00 31.39 ? 186 TYR L CE2 1 
ATOM   3045 C CZ  . TYR B 2 182 ? -40.377 -12.630 54.477  1.00 34.88 ? 186 TYR L CZ  1 
ATOM   3046 O OH  . TYR B 2 182 ? -39.760 -13.290 55.522  1.00 35.75 ? 186 TYR L OH  1 
ATOM   3047 N N   . GLU B 2 183 ? -45.437 -10.928 51.908  1.00 39.95 ? 187 GLU L N   1 
ATOM   3048 C CA  . GLU B 2 183 ? -46.463 -11.283 52.874  1.00 43.33 ? 187 GLU L CA  1 
ATOM   3049 C C   . GLU B 2 183 ? -47.632 -12.032 52.249  1.00 40.04 ? 187 GLU L C   1 
ATOM   3050 O O   . GLU B 2 183 ? -48.508 -12.501 52.982  1.00 43.59 ? 187 GLU L O   1 
ATOM   3051 C CB  . GLU B 2 183 ? -46.959 -10.019 53.585  1.00 41.07 ? 187 GLU L CB  1 
ATOM   3052 C CG  . GLU B 2 183 ? -45.902 -9.379  54.460  1.00 40.92 ? 187 GLU L CG  1 
ATOM   3053 C CD  . GLU B 2 183 ? -46.347 -8.034  54.981  1.00 49.49 ? 187 GLU L CD  1 
ATOM   3054 O OE1 . GLU B 2 183 ? -45.643 -7.459  55.835  1.00 52.78 ? 187 GLU L OE1 1 
ATOM   3055 O OE2 . GLU B 2 183 ? -47.410 -7.557  54.529  1.00 50.80 ? 187 GLU L OE2 1 
ATOM   3056 N N   . LYS B 2 184 ? -47.658 -12.170 50.921  1.00 38.71 ? 188 LYS L N   1 
ATOM   3057 C CA  . LYS B 2 184 ? -48.609 -13.053 50.261  1.00 43.41 ? 188 LYS L CA  1 
ATOM   3058 C C   . LYS B 2 184 ? -48.257 -14.538 50.410  1.00 45.26 ? 188 LYS L C   1 
ATOM   3059 O O   . LYS B 2 184 ? -49.105 -15.389 50.114  1.00 47.73 ? 188 LYS L O   1 
ATOM   3060 C CB  . LYS B 2 184 ? -48.702 -12.697 48.773  1.00 45.44 ? 188 LYS L CB  1 
ATOM   3061 C CG  . LYS B 2 184 ? -49.368 -11.363 48.453  1.00 44.16 ? 188 LYS L CG  1 
ATOM   3062 C CD  . LYS B 2 184 ? -49.948 -11.378 47.029  1.00 45.56 ? 188 LYS L CD  1 
ATOM   3063 C CE  . LYS B 2 184 ? -50.345 -9.974  46.534  1.00 50.23 ? 188 LYS L CE  1 
ATOM   3064 N NZ  . LYS B 2 184 ? -49.243 -9.290  45.783  1.00 48.08 ? 188 LYS L NZ  1 
ATOM   3065 N N   . HIS B 2 185 ? -47.048 -14.875 50.861  1.00 35.97 ? 189 HIS L N   1 
ATOM   3066 C CA  . HIS B 2 185 ? -46.562 -16.249 50.843  1.00 37.71 ? 189 HIS L CA  1 
ATOM   3067 C C   . HIS B 2 185 ? -45.989 -16.634 52.198  1.00 38.93 ? 189 HIS L C   1 
ATOM   3068 O O   . HIS B 2 185 ? -45.701 -15.784 53.047  1.00 33.95 ? 189 HIS L O   1 
ATOM   3069 C CB  . HIS B 2 185 ? -45.506 -16.453 49.758  1.00 34.93 ? 189 HIS L CB  1 
ATOM   3070 C CG  . HIS B 2 185 ? -45.992 -16.087 48.396  1.00 39.27 ? 189 HIS L CG  1 
ATOM   3071 N ND1 . HIS B 2 185 ? -46.823 -16.906 47.662  1.00 39.99 ? 189 HIS L ND1 1 
ATOM   3072 C CD2 . HIS B 2 185 ? -45.797 -14.975 47.648  1.00 43.18 ? 189 HIS L CD2 1 
ATOM   3073 C CE1 . HIS B 2 185 ? -47.104 -16.322 46.510  1.00 44.13 ? 189 HIS L CE1 1 
ATOM   3074 N NE2 . HIS B 2 185 ? -46.494 -15.149 46.477  1.00 45.73 ? 189 HIS L NE2 1 
ATOM   3075 N N   . LYS B 2 186 ? -45.835 -17.945 52.385  1.00 40.45 ? 190 LYS L N   1 
ATOM   3076 C CA  . LYS B 2 186 ? -45.460 -18.517 53.672  1.00 35.50 ? 190 LYS L CA  1 
ATOM   3077 C C   . LYS B 2 186 ? -44.068 -19.123 53.654  1.00 32.80 ? 190 LYS L C   1 
ATOM   3078 O O   . LYS B 2 186 ? -43.211 -18.723 54.450  1.00 35.67 ? 190 LYS L O   1 
ATOM   3079 C CB  . LYS B 2 186 ? -46.516 -19.567 54.082  1.00 42.43 ? 190 LYS L CB  1 
ATOM   3080 C CG  . LYS B 2 186 ? -46.258 -20.246 55.436  1.00 38.56 ? 190 LYS L CG  1 
ATOM   3081 C CD  . LYS B 2 186 ? -47.563 -20.658 56.120  1.00 47.15 ? 190 LYS L CD  1 
ATOM   3082 C CE  . LYS B 2 186 ? -47.936 -22.135 55.880  1.00 54.62 ? 190 LYS L CE  1 
ATOM   3083 N NZ  . LYS B 2 186 ? -47.129 -23.093 56.694  1.00 55.00 ? 190 LYS L NZ  1 
ATOM   3084 N N   . VAL B 2 187 ? -43.795 -20.068 52.747  1.00 31.82 ? 191 VAL L N   1 
ATOM   3085 C CA  . VAL B 2 187 ? -42.572 -20.864 52.779  1.00 34.16 ? 191 VAL L CA  1 
ATOM   3086 C C   . VAL B 2 187 ? -41.585 -20.321 51.758  1.00 30.15 ? 191 VAL L C   1 
ATOM   3087 O O   . VAL B 2 187 ? -41.906 -20.207 50.568  1.00 29.58 ? 191 VAL L O   1 
ATOM   3088 C CB  . VAL B 2 187 ? -42.862 -22.351 52.520  1.00 31.97 ? 191 VAL L CB  1 
ATOM   3089 C CG1 . VAL B 2 187 ? -41.553 -23.143 52.378  1.00 31.31 ? 191 VAL L CG1 1 
ATOM   3090 C CG2 . VAL B 2 187 ? -43.700 -22.899 53.639  1.00 31.44 ? 191 VAL L CG2 1 
ATOM   3091 N N   . TYR B 2 188 ? -40.382 -20.009 52.227  1.00 28.41 ? 192 TYR L N   1 
ATOM   3092 C CA  . TYR B 2 188 ? -39.289 -19.498 51.412  1.00 26.37 ? 192 TYR L CA  1 
ATOM   3093 C C   . TYR B 2 188 ? -38.131 -20.480 51.485  1.00 32.37 ? 192 TYR L C   1 
ATOM   3094 O O   . TYR B 2 188 ? -37.716 -20.863 52.581  1.00 27.94 ? 192 TYR L O   1 
ATOM   3095 C CB  . TYR B 2 188 ? -38.862 -18.099 51.895  1.00 28.76 ? 192 TYR L CB  1 
ATOM   3096 C CG  . TYR B 2 188 ? -39.901 -17.073 51.506  1.00 30.24 ? 192 TYR L CG  1 
ATOM   3097 C CD1 . TYR B 2 188 ? -40.976 -16.791 52.341  1.00 29.44 ? 192 TYR L CD1 1 
ATOM   3098 C CD2 . TYR B 2 188 ? -39.852 -16.453 50.267  1.00 31.68 ? 192 TYR L CD2 1 
ATOM   3099 C CE1 . TYR B 2 188 ? -41.947 -15.882 51.960  1.00 33.78 ? 192 TYR L CE1 1 
ATOM   3100 C CE2 . TYR B 2 188 ? -40.817 -15.546 49.875  1.00 31.86 ? 192 TYR L CE2 1 
ATOM   3101 C CZ  . TYR B 2 188 ? -41.858 -15.266 50.718  1.00 33.47 ? 192 TYR L CZ  1 
ATOM   3102 O OH  . TYR B 2 188 ? -42.822 -14.371 50.309  1.00 34.55 ? 192 TYR L OH  1 
ATOM   3103 N N   . ALA B 2 189 ? -37.609 -20.880 50.321  1.00 30.42 ? 193 ALA L N   1 
ATOM   3104 C CA  . ALA B 2 189 ? -36.623 -21.948 50.245  1.00 29.83 ? 193 ALA L CA  1 
ATOM   3105 C C   . ALA B 2 189 ? -35.641 -21.690 49.109  1.00 28.08 ? 193 ALA L C   1 
ATOM   3106 O O   . ALA B 2 189 ? -36.043 -21.263 48.025  1.00 28.90 ? 193 ALA L O   1 
ATOM   3107 C CB  . ALA B 2 189 ? -37.302 -23.312 50.042  1.00 25.93 ? 193 ALA L CB  1 
ATOM   3108 N N   . CYS B 2 190 ? -34.356 -21.963 49.348  1.00 28.07 ? 194 CYS L N   1 
ATOM   3109 C CA  . CYS B 2 190 ? -33.409 -22.145 48.257  1.00 28.63 ? 194 CYS L CA  1 
ATOM   3110 C C   . CYS B 2 190 ? -32.975 -23.600 48.196  1.00 29.56 ? 194 CYS L C   1 
ATOM   3111 O O   . CYS B 2 190 ? -32.615 -24.204 49.216  1.00 29.82 ? 194 CYS L O   1 
ATOM   3112 C CB  . CYS B 2 190 ? -32.164 -21.260 48.370  1.00 26.66 ? 194 CYS L CB  1 
ATOM   3113 S SG  . CYS B 2 190 ? -31.327 -21.363 49.906  1.00 41.11 ? 194 CYS L SG  1 
ATOM   3114 N N   . GLU B 2 191 ? -32.985 -24.135 46.987  1.00 24.73 ? 195 GLU L N   1 
ATOM   3115 C CA  . GLU B 2 191 ? -32.628 -25.514 46.719  1.00 32.57 ? 195 GLU L CA  1 
ATOM   3116 C C   . GLU B 2 191 ? -31.337 -25.521 45.924  1.00 33.88 ? 195 GLU L C   1 
ATOM   3117 O O   . GLU B 2 191 ? -31.255 -24.903 44.856  1.00 31.56 ? 195 GLU L O   1 
ATOM   3118 C CB  . GLU B 2 191 ? -33.726 -26.237 45.950  1.00 28.90 ? 195 GLU L CB  1 
ATOM   3119 C CG  . GLU B 2 191 ? -33.241 -27.542 45.386  1.00 32.99 ? 195 GLU L CG  1 
ATOM   3120 C CD  . GLU B 2 191 ? -34.372 -28.478 45.072  1.00 48.08 ? 195 GLU L CD  1 
ATOM   3121 O OE1 . GLU B 2 191 ? -35.272 -28.080 44.293  1.00 48.37 ? 195 GLU L OE1 1 
ATOM   3122 O OE2 . GLU B 2 191 ? -34.371 -29.606 45.624  1.00 58.43 ? 195 GLU L OE2 1 
ATOM   3123 N N   . VAL B 2 192 ? -30.353 -26.231 46.451  1.00 27.92 ? 196 VAL L N   1 
ATOM   3124 C CA  . VAL B 2 192 ? -29.003 -26.310 45.920  1.00 29.07 ? 196 VAL L CA  1 
ATOM   3125 C C   . VAL B 2 192 ? -28.809 -27.723 45.389  1.00 33.60 ? 196 VAL L C   1 
ATOM   3126 O O   . VAL B 2 192 ? -28.825 -28.679 46.171  1.00 34.33 ? 196 VAL L O   1 
ATOM   3127 C CB  . VAL B 2 192 ? -27.984 -26.013 47.028  1.00 27.80 ? 196 VAL L CB  1 
ATOM   3128 C CG1 . VAL B 2 192 ? -26.572 -26.132 46.522  1.00 31.13 ? 196 VAL L CG1 1 
ATOM   3129 C CG2 . VAL B 2 192 ? -28.260 -24.636 47.649  1.00 32.90 ? 196 VAL L CG2 1 
ATOM   3130 N N   . THR B 2 193 ? -28.610 -27.868 44.082  1.00 30.39 ? 197 THR L N   1 
ATOM   3131 C CA  . THR B 2 193 ? -28.378 -29.175 43.471  1.00 30.82 ? 197 THR L CA  1 
ATOM   3132 C C   . THR B 2 193 ? -26.927 -29.290 43.019  1.00 38.46 ? 197 THR L C   1 
ATOM   3133 O O   . THR B 2 193 ? -26.432 -28.422 42.301  1.00 39.53 ? 197 THR L O   1 
ATOM   3134 C CB  . THR B 2 193 ? -29.318 -29.414 42.288  1.00 33.98 ? 197 THR L CB  1 
ATOM   3135 O OG1 . THR B 2 193 ? -30.657 -29.556 42.770  1.00 31.30 ? 197 THR L OG1 1 
ATOM   3136 C CG2 . THR B 2 193 ? -28.913 -30.686 41.550  1.00 35.45 ? 197 THR L CG2 1 
ATOM   3137 N N   . GLN B 2 194 ? -26.228 -30.323 43.503  1.00 37.30 ? 198 GLN L N   1 
ATOM   3138 C CA  . GLN B 2 194 ? -24.848 -30.596 43.149  1.00 37.41 ? 198 GLN L CA  1 
ATOM   3139 C C   . GLN B 2 194 ? -24.656 -32.112 43.013  1.00 41.47 ? 198 GLN L C   1 
ATOM   3140 O O   . GLN B 2 194 ? -24.375 -32.819 43.979  1.00 41.62 ? 198 GLN L O   1 
ATOM   3141 C CB  . GLN B 2 194 ? -23.891 -30.009 44.190  1.00 39.33 ? 198 GLN L CB  1 
ATOM   3142 C CG  . GLN B 2 194 ? -22.410 -30.049 43.861  1.00 41.54 ? 198 GLN L CG  1 
ATOM   3143 C CD  . GLN B 2 194 ? -21.577 -30.309 45.105  1.00 44.55 ? 198 GLN L CD  1 
ATOM   3144 O OE1 . GLN B 2 194 ? -22.076 -30.868 46.087  1.00 46.79 ? 198 GLN L OE1 1 
ATOM   3145 N NE2 . GLN B 2 194 ? -20.306 -29.920 45.071  1.00 40.19 ? 198 GLN L NE2 1 
ATOM   3146 N N   . GLY B 2 195 ? -24.854 -32.646 41.813  1.00 40.51 ? 199 GLY L N   1 
ATOM   3147 C CA  . GLY B 2 195 ? -24.319 -33.969 41.548  1.00 39.62 ? 199 GLY L CA  1 
ATOM   3148 C C   . GLY B 2 195 ? -24.808 -35.092 42.451  1.00 45.72 ? 199 GLY L C   1 
ATOM   3149 O O   . GLY B 2 195 ? -24.045 -35.552 43.307  1.00 51.24 ? 199 GLY L O   1 
ATOM   3150 N N   . THR B 2 196 ? -26.059 -35.524 42.313  1.00 43.28 ? 200 THR L N   1 
ATOM   3151 C CA  . THR B 2 196 ? -26.717 -36.533 43.162  1.00 43.52 ? 200 THR L CA  1 
ATOM   3152 C C   . THR B 2 196 ? -27.021 -36.039 44.568  1.00 39.65 ? 200 THR L C   1 
ATOM   3153 O O   . THR B 2 196 ? -27.309 -36.856 45.443  1.00 42.72 ? 200 THR L O   1 
ATOM   3154 C CB  . THR B 2 196 ? -25.950 -37.864 43.330  1.00 44.61 ? 200 THR L CB  1 
ATOM   3155 O OG1 . THR B 2 196 ? -25.043 -37.780 44.449  1.00 40.64 ? 200 THR L OG1 1 
ATOM   3156 C CG2 . THR B 2 196 ? -25.218 -38.290 42.067  1.00 45.28 ? 200 THR L CG2 1 
ATOM   3157 N N   . THR B 2 197 ? -26.954 -34.740 44.827  1.00 39.47 ? 201 THR L N   1 
ATOM   3158 C CA  . THR B 2 197 ? -27.450 -34.206 46.087  1.00 37.60 ? 201 THR L CA  1 
ATOM   3159 C C   . THR B 2 197 ? -28.221 -32.925 45.811  1.00 32.83 ? 201 THR L C   1 
ATOM   3160 O O   . THR B 2 197 ? -27.720 -32.032 45.123  1.00 32.91 ? 201 THR L O   1 
ATOM   3161 C CB  . THR B 2 197 ? -26.303 -33.944 47.067  1.00 41.26 ? 201 THR L CB  1 
ATOM   3162 O OG1 . THR B 2 197 ? -25.387 -35.039 47.018  1.00 42.38 ? 201 THR L OG1 1 
ATOM   3163 C CG2 . THR B 2 197 ? -26.831 -33.807 48.489  1.00 39.16 ? 201 THR L CG2 1 
ATOM   3164 N N   . SER B 2 198 ? -29.450 -32.849 46.306  1.00 33.78 ? 202 SER L N   1 
ATOM   3165 C CA  . SER B 2 198 ? -30.163 -31.583 46.422  1.00 32.64 ? 202 SER L CA  1 
ATOM   3166 C C   . SER B 2 198 ? -30.345 -31.290 47.896  1.00 34.13 ? 202 SER L C   1 
ATOM   3167 O O   . SER B 2 198 ? -30.793 -32.167 48.647  1.00 31.21 ? 202 SER L O   1 
ATOM   3168 C CB  . SER B 2 198 ? -31.524 -31.616 45.736  1.00 31.47 ? 202 SER L CB  1 
ATOM   3169 O OG  . SER B 2 198 ? -31.347 -31.676 44.340  1.00 45.61 ? 202 SER L OG  1 
ATOM   3170 N N   . VAL B 2 199 ? -29.974 -30.077 48.301  1.00 27.70 ? 203 VAL L N   1 
ATOM   3171 C CA  . VAL B 2 199 ? -30.190 -29.570 49.649  1.00 25.67 ? 203 VAL L CA  1 
ATOM   3172 C C   . VAL B 2 199 ? -31.130 -28.374 49.565  1.00 29.41 ? 203 VAL L C   1 
ATOM   3173 O O   . VAL B 2 199 ? -30.870 -27.436 48.803  1.00 29.64 ? 203 VAL L O   1 
ATOM   3174 C CB  . VAL B 2 199 ? -28.865 -29.169 50.313  1.00 23.15 ? 203 VAL L CB  1 
ATOM   3175 C CG1 . VAL B 2 199 ? -29.143 -28.451 51.645  1.00 24.54 ? 203 VAL L CG1 1 
ATOM   3176 C CG2 . VAL B 2 199 ? -27.991 -30.388 50.511  1.00 23.57 ? 203 VAL L CG2 1 
ATOM   3177 N N   . THR B 2 200 ? -32.208 -28.397 50.359  1.00 28.68 ? 204 THR L N   1 
ATOM   3178 C CA  . THR B 2 200 ? -33.196 -27.319 50.395  1.00 28.77 ? 204 THR L CA  1 
ATOM   3179 C C   . THR B 2 200 ? -33.283 -26.735 51.808  1.00 33.50 ? 204 THR L C   1 
ATOM   3180 O O   . THR B 2 200 ? -33.745 -27.412 52.733  1.00 28.63 ? 204 THR L O   1 
ATOM   3181 C CB  . THR B 2 200 ? -34.564 -27.822 49.946  1.00 30.14 ? 204 THR L CB  1 
ATOM   3182 O OG1 . THR B 2 200 ? -34.492 -28.305 48.599  1.00 31.26 ? 204 THR L OG1 1 
ATOM   3183 C CG2 . THR B 2 200 ? -35.610 -26.701 50.039  1.00 32.29 ? 204 THR L CG2 1 
ATOM   3184 N N   . LYS B 2 201 ? -32.866 -25.471 51.964  1.00 34.26 ? 205 LYS L N   1 
ATOM   3185 C CA  . LYS B 2 201 ? -32.987 -24.706 53.206  1.00 25.25 ? 205 LYS L CA  1 
ATOM   3186 C C   . LYS B 2 201 ? -34.179 -23.773 53.109  1.00 30.29 ? 205 LYS L C   1 
ATOM   3187 O O   . LYS B 2 201 ? -34.379 -23.109 52.086  1.00 28.84 ? 205 LYS L O   1 
ATOM   3188 C CB  . LYS B 2 201 ? -31.743 -23.860 53.481  1.00 29.95 ? 205 LYS L CB  1 
ATOM   3189 C CG  . LYS B 2 201 ? -30.746 -24.452 54.456  1.00 37.40 ? 205 LYS L CG  1 
ATOM   3190 C CD  . LYS B 2 201 ? -31.322 -24.604 55.848  1.00 32.72 ? 205 LYS L CD  1 
ATOM   3191 C CE  . LYS B 2 201 ? -30.209 -24.494 56.887  1.00 30.92 ? 205 LYS L CE  1 
ATOM   3192 N NZ  . LYS B 2 201 ? -30.281 -25.544 57.943  1.00 34.77 ? 205 LYS L NZ  1 
ATOM   3193 N N   . SER B 2 202 ? -34.963 -23.698 54.174  1.00 22.92 ? 206 SER L N   1 
ATOM   3194 C CA  . SER B 2 202 ? -36.199 -22.947 54.077  1.00 27.41 ? 206 SER L CA  1 
ATOM   3195 C C   . SER B 2 202 ? -36.518 -22.300 55.411  1.00 31.43 ? 206 SER L C   1 
ATOM   3196 O O   . SER B 2 202 ? -35.825 -22.507 56.411  1.00 29.29 ? 206 SER L O   1 
ATOM   3197 C CB  . SER B 2 202 ? -37.350 -23.855 53.654  1.00 28.12 ? 206 SER L CB  1 
ATOM   3198 O OG  . SER B 2 202 ? -37.489 -24.852 54.638  1.00 33.27 ? 206 SER L OG  1 
ATOM   3199 N N   . PHE B 2 203 ? -37.582 -21.497 55.406  1.00 31.91 ? 207 PHE L N   1 
ATOM   3200 C CA  . PHE B 2 203 ? -38.186 -20.999 56.634  1.00 31.18 ? 207 PHE L CA  1 
ATOM   3201 C C   . PHE B 2 203 ? -39.621 -20.606 56.321  1.00 36.48 ? 207 PHE L C   1 
ATOM   3202 O O   . PHE B 2 203 ? -39.999 -20.436 55.155  1.00 34.58 ? 207 PHE L O   1 
ATOM   3203 C CB  . PHE B 2 203 ? -37.404 -19.814 57.212  1.00 32.43 ? 207 PHE L CB  1 
ATOM   3204 C CG  . PHE B 2 203 ? -37.408 -18.599 56.321  1.00 34.75 ? 207 PHE L CG  1 
ATOM   3205 C CD1 . PHE B 2 203 ? -38.429 -17.657 56.404  1.00 37.00 ? 207 PHE L CD1 1 
ATOM   3206 C CD2 . PHE B 2 203 ? -36.399 -18.400 55.393  1.00 31.89 ? 207 PHE L CD2 1 
ATOM   3207 C CE1 . PHE B 2 203 ? -38.436 -16.535 55.574  1.00 36.29 ? 207 PHE L CE1 1 
ATOM   3208 C CE2 . PHE B 2 203 ? -36.406 -17.281 54.569  1.00 32.80 ? 207 PHE L CE2 1 
ATOM   3209 C CZ  . PHE B 2 203 ? -37.429 -16.355 54.659  1.00 26.87 ? 207 PHE L CZ  1 
ATOM   3210 N N   . ASN B 2 204 ? -40.420 -20.466 57.376  1.00 37.54 ? 208 ASN L N   1 
ATOM   3211 C CA  . ASN B 2 204 ? -41.757 -19.895 57.269  1.00 40.91 ? 208 ASN L CA  1 
ATOM   3212 C C   . ASN B 2 204 ? -41.715 -18.451 57.739  1.00 44.08 ? 208 ASN L C   1 
ATOM   3213 O O   . ASN B 2 204 ? -41.192 -18.161 58.825  1.00 36.51 ? 208 ASN L O   1 
ATOM   3214 C CB  . ASN B 2 204 ? -42.776 -20.684 58.089  1.00 43.38 ? 208 ASN L CB  1 
ATOM   3215 C CG  . ASN B 2 204 ? -43.048 -22.042 57.500  1.00 48.85 ? 208 ASN L CG  1 
ATOM   3216 O OD1 . ASN B 2 204 ? -42.147 -22.670 56.947  1.00 53.09 ? 208 ASN L OD1 1 
ATOM   3217 N ND2 . ASN B 2 204 ? -44.292 -22.499 57.590  1.00 54.55 ? 208 ASN L ND2 1 
ATOM   3218 N N   . ARG B 2 205 ? -42.277 -17.553 56.920  1.00 44.85 ? 209 ARG L N   1 
ATOM   3219 C CA  . ARG B 2 205 ? -42.209 -16.122 57.215  1.00 46.73 ? 209 ARG L CA  1 
ATOM   3220 C C   . ARG B 2 205 ? -42.748 -15.811 58.607  1.00 52.37 ? 209 ARG L C   1 
ATOM   3221 O O   . ARG B 2 205 ? -42.196 -14.964 59.327  1.00 57.29 ? 209 ARG L O   1 
ATOM   3222 C CB  . ARG B 2 205 ? -42.979 -15.330 56.158  1.00 40.58 ? 209 ARG L CB  1 
ATOM   3223 C CG  . ARG B 2 205 ? -43.203 -13.870 56.542  1.00 41.95 ? 209 ARG L CG  1 
ATOM   3224 C CD  . ARG B 2 205 ? -43.955 -13.122 55.457  1.00 36.61 ? 209 ARG L CD  1 
ATOM   3225 N NE  . ARG B 2 205 ? -45.133 -13.858 55.039  1.00 37.62 ? 209 ARG L NE  1 
ATOM   3226 C CZ  . ARG B 2 205 ? -46.273 -13.862 55.711  1.00 41.40 ? 209 ARG L CZ  1 
ATOM   3227 N NH1 . ARG B 2 205 ? -46.413 -13.170 56.831  1.00 40.47 ? 209 ARG L NH1 1 
ATOM   3228 N NH2 . ARG B 2 205 ? -47.291 -14.588 55.256  1.00 36.90 ? 209 ARG L NH2 1 
ATOM   3229 N N   . GLY B 2 206 ? -43.800 -16.512 59.019  1.00 43.48 ? 210 GLY L N   1 
ATOM   3230 C CA  . GLY B 2 206 ? -44.410 -16.220 60.308  1.00 65.70 ? 210 GLY L CA  1 
ATOM   3231 C C   . GLY B 2 206 ? -43.558 -16.557 61.525  1.00 69.14 ? 210 GLY L C   1 
ATOM   3232 O O   . GLY B 2 206 ? -43.956 -16.216 62.646  1.00 67.43 ? 210 GLY L O   1 
ATOM   3233 N N   . GLU B 2 207 ? -42.414 -17.222 61.341  1.00 60.63 ? 211 GLU L N   1 
ATOM   3234 C CA  . GLU B 2 207 ? -41.546 -17.587 62.454  1.00 63.87 ? 211 GLU L CA  1 
ATOM   3235 C C   . GLU B 2 207 ? -40.127 -17.058 62.279  1.00 71.53 ? 211 GLU L C   1 
ATOM   3236 O O   . GLU B 2 207 ? -39.198 -17.555 62.930  1.00 77.72 ? 211 GLU L O   1 
ATOM   3237 C CB  . GLU B 2 207 ? -41.535 -19.104 62.635  1.00 67.66 ? 211 GLU L CB  1 
ATOM   3238 C CG  . GLU B 2 207 ? -42.878 -19.659 63.056  1.00 71.80 ? 211 GLU L CG  1 
ATOM   3239 C CD  . GLU B 2 207 ? -43.056 -21.101 62.653  1.00 76.29 ? 211 GLU L CD  1 
ATOM   3240 O OE1 . GLU B 2 207 ? -43.561 -21.343 61.534  1.00 65.89 ? 211 GLU L OE1 1 
ATOM   3241 O OE2 . GLU B 2 207 ? -42.681 -21.988 63.454  1.00 81.30 ? 211 GLU L OE2 1 
ATOM   3242 N N   . CYS B 2 208 ? -39.942 -16.047 61.430  1.00 65.90 ? 212 CYS L N   1 
ATOM   3243 C CA  . CYS B 2 208 ? -38.611 -15.516 61.137  1.00 69.82 ? 212 CYS L CA  1 
ATOM   3244 C C   . CYS B 2 208 ? -38.687 -14.131 60.476  1.00 70.72 ? 212 CYS L C   1 
ATOM   3245 O O   . CYS B 2 208 ? -38.071 -13.165 60.946  1.00 68.77 ? 212 CYS L O   1 
ATOM   3246 C CB  . CYS B 2 208 ? -37.842 -16.495 60.240  1.00 60.37 ? 212 CYS L CB  1 
ATOM   3247 S SG  . CYS B 2 208 ? -36.532 -17.467 61.061  1.00 74.42 ? 212 CYS L SG  1 
ATOM   3248 N N   . ASP C 3 1   ? -6.843  22.451  -12.552 1.00 37.58 ? 1   ASP C N   1 
ATOM   3249 C CA  . ASP C 3 1   ? -7.576  22.597  -11.297 1.00 32.86 ? 1   ASP C CA  1 
ATOM   3250 C C   . ASP C 3 1   ? -6.714  22.184  -10.096 1.00 29.36 ? 1   ASP C C   1 
ATOM   3251 O O   . ASP C 3 1   ? -5.974  21.201  -10.153 1.00 27.05 ? 1   ASP C O   1 
ATOM   3252 C CB  . ASP C 3 1   ? -8.886  21.798  -11.328 1.00 36.21 ? 1   ASP C CB  1 
ATOM   3253 C CG  . ASP C 3 1   ? -8.683  20.288  -11.353 1.00 38.51 ? 1   ASP C CG  1 
ATOM   3254 O OD1 . ASP C 3 1   ? -8.003  19.755  -12.259 1.00 40.76 ? 1   ASP C OD1 1 
ATOM   3255 O OD2 . ASP C 3 1   ? -9.251  19.622  -10.463 1.00 31.64 ? 1   ASP C OD2 1 
ATOM   3256 N N   . THR C 3 2   ? -6.813  22.950  -9.018  1.00 26.06 ? 2   THR C N   1 
ATOM   3257 C CA  . THR C 3 2   ? -5.873  22.869  -7.917  1.00 30.11 ? 2   THR C CA  1 
ATOM   3258 C C   . THR C 3 2   ? -6.558  22.456  -6.622  1.00 28.82 ? 2   THR C C   1 
ATOM   3259 O O   . THR C 3 2   ? -7.761  22.671  -6.421  1.00 25.74 ? 2   THR C O   1 
ATOM   3260 C CB  . THR C 3 2   ? -5.184  24.210  -7.675  1.00 32.30 ? 2   THR C CB  1 
ATOM   3261 O OG1 . THR C 3 2   ? -6.188  25.194  -7.397  1.00 33.19 ? 2   THR C OG1 1 
ATOM   3262 C CG2 . THR C 3 2   ? -4.345  24.626  -8.897  1.00 28.39 ? 2   THR C CG2 1 
ATOM   3263 N N   . ILE C 3 3   ? -5.752  21.869  -5.744  1.00 26.72 ? 3   ILE C N   1 
ATOM   3264 C CA  . ILE C 3 3   ? -6.077  21.712  -4.337  1.00 24.30 ? 3   ILE C CA  1 
ATOM   3265 C C   . ILE C 3 3   ? -5.423  22.877  -3.627  1.00 27.10 ? 3   ILE C C   1 
ATOM   3266 O O   . ILE C 3 3   ? -4.194  22.904  -3.485  1.00 27.60 ? 3   ILE C O   1 
ATOM   3267 C CB  . ILE C 3 3   ? -5.554  20.383  -3.779  1.00 25.94 ? 3   ILE C CB  1 
ATOM   3268 C CG1 . ILE C 3 3   ? -6.268  19.206  -4.419  1.00 23.70 ? 3   ILE C CG1 1 
ATOM   3269 C CG2 . ILE C 3 3   ? -5.705  20.361  -2.256  1.00 22.16 ? 3   ILE C CG2 1 
ATOM   3270 C CD1 . ILE C 3 3   ? -5.575  17.845  -4.138  1.00 23.05 ? 3   ILE C CD1 1 
ATOM   3271 N N   . THR C 3 4   ? -6.221  23.835  -3.160  1.00 23.55 ? 4   THR C N   1 
ATOM   3272 C CA  . THR C 3 4   ? -5.699  25.078  -2.603  1.00 24.78 ? 4   THR C CA  1 
ATOM   3273 C C   . THR C 3 4   ? -5.773  25.005  -1.084  1.00 26.87 ? 4   THR C C   1 
ATOM   3274 O O   . THR C 3 4   ? -6.854  25.095  -0.504  1.00 22.52 ? 4   THR C O   1 
ATOM   3275 C CB  . THR C 3 4   ? -6.477  26.266  -3.164  1.00 22.12 ? 4   THR C CB  1 
ATOM   3276 O OG1 . THR C 3 4   ? -6.309  26.289  -4.586  1.00 29.24 ? 4   THR C OG1 1 
ATOM   3277 C CG2 . THR C 3 4   ? -5.980  27.573  -2.607  1.00 20.89 ? 4   THR C CG2 1 
ATOM   3278 N N   . LEU C 3 5   ? -4.597  24.832  -0.432  1.00 26.16 ? 5   LEU C N   1 
ATOM   3279 C CA  . LEU C 3 5   ? -4.476  24.637  1.017   1.00 22.86 ? 5   LEU C CA  1 
ATOM   3280 C C   . LEU C 3 5   ? -4.373  25.979  1.727   1.00 24.94 ? 5   LEU C C   1 
ATOM   3281 O O   . LEU C 3 5   ? -3.562  26.814  1.321   1.00 26.72 ? 5   LEU C O   1 
ATOM   3282 C CB  . LEU C 3 5   ? -3.229  23.810  1.344   1.00 20.18 ? 5   LEU C CB  1 
ATOM   3283 C CG  . LEU C 3 5   ? -3.051  22.510  0.571   1.00 24.05 ? 5   LEU C CG  1 
ATOM   3284 C CD1 . LEU C 3 5   ? -1.746  21.817  1.008   1.00 25.90 ? 5   LEU C CD1 1 
ATOM   3285 C CD2 . LEU C 3 5   ? -4.237  21.613  0.849   1.00 24.68 ? 5   LEU C CD2 1 
ATOM   3286 N N   . PRO C 3 6   ? -5.134  26.222  2.798   1.00 21.14 ? 6   PRO C N   1 
ATOM   3287 C CA  . PRO C 3 6   ? -4.865  27.397  3.628   1.00 23.24 ? 6   PRO C CA  1 
ATOM   3288 C C   . PRO C 3 6   ? -3.639  27.160  4.492   1.00 27.70 ? 6   PRO C C   1 
ATOM   3289 O O   . PRO C 3 6   ? -3.446  26.070  5.037   1.00 23.62 ? 6   PRO C O   1 
ATOM   3290 C CB  . PRO C 3 6   ? -6.136  27.523  4.487   1.00 27.17 ? 6   PRO C CB  1 
ATOM   3291 C CG  . PRO C 3 6   ? -6.580  26.118  4.665   1.00 21.88 ? 6   PRO C CG  1 
ATOM   3292 C CD  . PRO C 3 6   ? -6.126  25.333  3.428   1.00 21.90 ? 6   PRO C CD  1 
ATOM   3293 N N   . CYS C 3 7   ? -2.815  28.202  4.624   1.00 26.50 ? 7   CYS C N   1 
ATOM   3294 C CA  . CYS C 3 7   ? -1.565  28.123  5.368   1.00 27.67 ? 7   CYS C CA  1 
ATOM   3295 C C   . CYS C 3 7   ? -1.390  29.384  6.204   1.00 30.10 ? 7   CYS C C   1 
ATOM   3296 O O   . CYS C 3 7   ? -1.822  30.471  5.810   1.00 33.20 ? 7   CYS C O   1 
ATOM   3297 C CB  . CYS C 3 7   ? -0.362  27.952  4.420   1.00 21.15 ? 7   CYS C CB  1 
ATOM   3298 S SG  . CYS C 3 7   ? -0.505  26.621  3.221   1.00 28.38 ? 7   CYS C SG  1 
ATOM   3299 N N   . ARG C 3 8   ? -0.733  29.236  7.363   1.00 30.77 ? 8   ARG C N   1 
ATOM   3300 C CA  . ARG C 3 8   ? -0.516  30.362  8.271   1.00 28.74 ? 8   ARG C CA  1 
ATOM   3301 C C   . ARG C 3 8   ? 0.843   30.186  8.931   1.00 30.68 ? 8   ARG C C   1 
ATOM   3302 O O   . ARG C 3 8   ? 1.183   29.059  9.314   1.00 29.02 ? 8   ARG C O   1 
ATOM   3303 C CB  . ARG C 3 8   ? -1.612  30.486  9.339   1.00 36.22 ? 8   ARG C CB  1 
ATOM   3304 C CG  . ARG C 3 8   ? -2.899  31.055  8.743   1.00 40.72 ? 8   ARG C CG  1 
ATOM   3305 C CD  . ARG C 3 8   ? -4.157  30.910  9.598   1.00 54.66 ? 8   ARG C CD  1 
ATOM   3306 N NE  . ARG C 3 8   ? -5.242  31.742  9.074   1.00 57.41 ? 8   ARG C NE  1 
ATOM   3307 C CZ  . ARG C 3 8   ? -5.808  31.599  7.878   1.00 59.37 ? 8   ARG C CZ  1 
ATOM   3308 N NH1 . ARG C 3 8   ? -5.433  30.647  7.035   1.00 52.01 ? 8   ARG C NH1 1 
ATOM   3309 N NH2 . ARG C 3 8   ? -6.766  32.445  7.508   1.00 66.22 ? 8   ARG C NH2 1 
ATOM   3310 N N   . PRO C 3 9   ? 1.670   31.239  8.990   1.00 28.24 ? 9   PRO C N   1 
ATOM   3311 C CA  . PRO C 3 9   ? 1.546   32.515  8.270   1.00 30.52 ? 9   PRO C CA  1 
ATOM   3312 C C   . PRO C 3 9   ? 1.550   32.246  6.777   1.00 28.47 ? 9   PRO C C   1 
ATOM   3313 O O   . PRO C 3 9   ? 1.842   31.130  6.366   1.00 25.59 ? 9   PRO C O   1 
ATOM   3314 C CB  . PRO C 3 9   ? 2.809   33.291  8.692   1.00 32.01 ? 9   PRO C CB  1 
ATOM   3315 C CG  . PRO C 3 9   ? 3.330   32.581  9.918   1.00 29.68 ? 9   PRO C CG  1 
ATOM   3316 C CD  . PRO C 3 9   ? 2.964   31.145  9.692   1.00 30.10 ? 9   PRO C CD  1 
ATOM   3317 N N   . ALA C 3 10  ? 1.264   33.230  5.950   1.00 29.90 ? 10  ALA C N   1 
ATOM   3318 C CA  . ALA C 3 10  ? 1.319   33.031  4.506   1.00 30.86 ? 10  ALA C CA  1 
ATOM   3319 C C   . ALA C 3 10  ? 2.744   32.751  4.050   1.00 30.02 ? 10  ALA C C   1 
ATOM   3320 O O   . ALA C 3 10  ? 3.618   33.610  4.228   1.00 32.27 ? 10  ALA C O   1 
ATOM   3321 C CB  . ALA C 3 10  ? 0.799   34.269  3.795   1.00 26.15 ? 10  ALA C CB  1 
ATOM   3322 N N   . PRO C 3 11  ? 3.021   31.608  3.431   1.00 26.73 ? 11  PRO C N   1 
ATOM   3323 C CA  . PRO C 3 11  ? 4.343   31.389  2.839   1.00 27.79 ? 11  PRO C CA  1 
ATOM   3324 C C   . PRO C 3 11  ? 4.509   32.224  1.583   1.00 34.58 ? 11  PRO C C   1 
ATOM   3325 O O   . PRO C 3 11  ? 3.582   32.323  0.766   1.00 31.94 ? 11  PRO C O   1 
ATOM   3326 C CB  . PRO C 3 11  ? 4.348   29.888  2.504   1.00 28.34 ? 11  PRO C CB  1 
ATOM   3327 C CG  . PRO C 3 11  ? 3.208   29.299  3.277   1.00 26.54 ? 11  PRO C CG  1 
ATOM   3328 C CD  . PRO C 3 11  ? 2.188   30.401  3.379   1.00 28.04 ? 11  PRO C CD  1 
ATOM   3329 N N   . PRO C 3 12  ? 5.674   32.836  1.389   1.00 32.21 ? 12  PRO C N   1 
ATOM   3330 C CA  . PRO C 3 12  ? 5.923   33.585  0.153   1.00 28.84 ? 12  PRO C CA  1 
ATOM   3331 C C   . PRO C 3 12  ? 6.189   32.653  -1.012  1.00 28.54 ? 12  PRO C C   1 
ATOM   3332 O O   . PRO C 3 12  ? 6.451   31.451  -0.827  1.00 29.78 ? 12  PRO C O   1 
ATOM   3333 C CB  . PRO C 3 12  ? 7.157   34.435  0.498   1.00 34.99 ? 12  PRO C CB  1 
ATOM   3334 C CG  . PRO C 3 12  ? 7.810   33.739  1.626   1.00 31.79 ? 12  PRO C CG  1 
ATOM   3335 C CD  . PRO C 3 12  ? 6.712   33.071  2.409   1.00 30.12 ? 12  PRO C CD  1 
ATOM   3336 N N   . PRO C 3 13  ? 6.095   33.152  -2.246  1.00 30.69 ? 13  PRO C N   1 
ATOM   3337 C CA  . PRO C 3 13  ? 6.234   32.250  -3.398  1.00 27.70 ? 13  PRO C CA  1 
ATOM   3338 C C   . PRO C 3 13  ? 7.575   31.552  -3.448  1.00 24.84 ? 13  PRO C C   1 
ATOM   3339 O O   . PRO C 3 13  ? 7.656   30.433  -3.976  1.00 30.63 ? 13  PRO C O   1 
ATOM   3340 C CB  . PRO C 3 13  ? 6.023   33.178  -4.604  1.00 26.31 ? 13  PRO C CB  1 
ATOM   3341 C CG  . PRO C 3 13  ? 5.275   34.328  -4.066  1.00 29.89 ? 13  PRO C CG  1 
ATOM   3342 C CD  . PRO C 3 13  ? 5.715   34.518  -2.646  1.00 30.99 ? 13  PRO C CD  1 
ATOM   3343 N N   . HIS C 3 14  ? 8.626   32.179  -2.906  1.00 27.67 ? 14  HIS C N   1 
ATOM   3344 C CA  . HIS C 3 14  ? 9.950   31.560  -2.860  1.00 32.89 ? 14  HIS C CA  1 
ATOM   3345 C C   . HIS C 3 14  ? 9.995   30.324  -1.973  1.00 29.65 ? 14  HIS C C   1 
ATOM   3346 O O   . HIS C 3 14  ? 10.964  29.566  -2.056  1.00 31.15 ? 14  HIS C O   1 
ATOM   3347 C CB  . HIS C 3 14  ? 11.004  32.559  -2.362  1.00 32.67 ? 14  HIS C CB  1 
ATOM   3348 C CG  . HIS C 3 14  ? 11.269  33.685  -3.308  1.00 32.86 ? 14  HIS C CG  1 
ATOM   3349 N ND1 . HIS C 3 14  ? 10.979  33.612  -4.655  1.00 43.23 ? 14  HIS C ND1 1 
ATOM   3350 C CD2 . HIS C 3 14  ? 11.796  34.916  -3.103  1.00 35.73 ? 14  HIS C CD2 1 
ATOM   3351 C CE1 . HIS C 3 14  ? 11.315  34.749  -5.241  1.00 43.09 ? 14  HIS C CE1 1 
ATOM   3352 N NE2 . HIS C 3 14  ? 11.809  35.559  -4.320  1.00 45.55 ? 14  HIS C NE2 1 
ATOM   3353 N N   . CYS C 3 15  ? 8.987   30.109  -1.119  1.00 28.91 ? 15  CYS C N   1 
ATOM   3354 C CA  . CYS C 3 15  ? 8.907   28.902  -0.299  1.00 28.59 ? 15  CYS C CA  1 
ATOM   3355 C C   . CYS C 3 15  ? 8.144   27.770  -0.970  1.00 27.25 ? 15  CYS C C   1 
ATOM   3356 O O   . CYS C 3 15  ? 7.956   26.724  -0.344  1.00 31.30 ? 15  CYS C O   1 
ATOM   3357 C CB  . CYS C 3 15  ? 8.275   29.204  1.058   1.00 25.93 ? 15  CYS C CB  1 
ATOM   3358 S SG  . CYS C 3 15  ? 9.246   30.309  2.077   1.00 31.42 ? 15  CYS C SG  1 
ATOM   3359 N N   . SER C 3 16  ? 7.748   27.937  -2.229  1.00 23.89 ? 16  SER C N   1 
ATOM   3360 C CA  . SER C 3 16  ? 7.192   26.840  -3.013  1.00 26.64 ? 16  SER C CA  1 
ATOM   3361 C C   . SER C 3 16  ? 8.215   25.719  -3.119  1.00 27.29 ? 16  SER C C   1 
ATOM   3362 O O   . SER C 3 16  ? 9.425   25.958  -3.126  1.00 30.89 ? 16  SER C O   1 
ATOM   3363 C CB  . SER C 3 16  ? 6.797   27.329  -4.421  1.00 22.91 ? 16  SER C CB  1 
ATOM   3364 O OG  . SER C 3 16  ? 5.943   28.468  -4.341  1.00 21.98 ? 16  SER C OG  1 
ATOM   3365 N N   . SER C 3 17  ? 7.734   24.483  -3.218  1.00 20.87 ? 17  SER C N   1 
ATOM   3366 C CA  . SER C 3 17  ? 8.620   23.333  -3.105  1.00 22.46 ? 17  SER C CA  1 
ATOM   3367 C C   . SER C 3 17  ? 8.165   22.236  -4.041  1.00 25.44 ? 17  SER C C   1 
ATOM   3368 O O   . SER C 3 17  ? 7.107   22.311  -4.669  1.00 25.75 ? 17  SER C O   1 
ATOM   3369 C CB  . SER C 3 17  ? 8.658   22.782  -1.679  1.00 19.71 ? 17  SER C CB  1 
ATOM   3370 O OG  . SER C 3 17  ? 8.997   23.833  -0.808  1.00 27.34 ? 17  SER C OG  1 
ATOM   3371 N N   . ASN C 3 18  ? 8.965   21.186  -4.100  1.00 21.19 ? 18  ASN C N   1 
ATOM   3372 C CA  . ASN C 3 18  ? 8.571   19.955  -4.750  1.00 20.46 ? 18  ASN C CA  1 
ATOM   3373 C C   . ASN C 3 18  ? 8.316   18.924  -3.667  1.00 25.43 ? 18  ASN C C   1 
ATOM   3374 O O   . ASN C 3 18  ? 9.157   18.734  -2.777  1.00 24.45 ? 18  ASN C O   1 
ATOM   3375 C CB  . ASN C 3 18  ? 9.641   19.489  -5.734  1.00 26.06 ? 18  ASN C CB  1 
ATOM   3376 C CG  . ASN C 3 18  ? 9.423   20.061  -7.114  1.00 31.29 ? 18  ASN C CG  1 
ATOM   3377 O OD1 . ASN C 3 18  ? 8.315   19.982  -7.633  1.00 33.92 ? 18  ASN C OD1 1 
ATOM   3378 N ND2 . ASN C 3 18  ? 10.461  20.647  -7.709  1.00 34.74 ? 18  ASN C ND2 1 
ATOM   3379 N N   . ILE C 3 19  ? 7.150   18.286  -3.727  1.00 24.18 ? 19  ILE C N   1 
ATOM   3380 C CA  . ILE C 3 19  ? 6.838   17.182  -2.828  1.00 20.91 ? 19  ILE C CA  1 
ATOM   3381 C C   . ILE C 3 19  ? 7.466   15.927  -3.400  1.00 18.53 ? 19  ILE C C   1 
ATOM   3382 O O   . ILE C 3 19  ? 7.188   15.553  -4.540  1.00 18.37 ? 19  ILE C O   1 
ATOM   3383 C CB  . ILE C 3 19  ? 5.319   17.018  -2.654  1.00 22.25 ? 19  ILE C CB  1 
ATOM   3384 C CG1 . ILE C 3 19  ? 4.734   18.264  -1.963  1.00 17.01 ? 19  ILE C CG1 1 
ATOM   3385 C CG2 . ILE C 3 19  ? 5.003   15.699  -1.913  1.00 19.51 ? 19  ILE C CG2 1 
ATOM   3386 C CD1 . ILE C 3 19  ? 3.212   18.511  -2.276  1.00 18.79 ? 19  ILE C CD1 1 
ATOM   3387 N N   . THR C 3 20  ? 8.353   15.297  -2.617  1.00 17.14 ? 20  THR C N   1 
ATOM   3388 C CA  . THR C 3 20  ? 9.144   14.154  -3.041  1.00 19.36 ? 20  THR C CA  1 
ATOM   3389 C C   . THR C 3 20  ? 8.802   12.878  -2.272  1.00 22.86 ? 20  THR C C   1 
ATOM   3390 O O   . THR C 3 20  ? 9.242   11.791  -2.671  1.00 17.95 ? 20  THR C O   1 
ATOM   3391 C CB  . THR C 3 20  ? 10.654  14.454  -2.862  1.00 25.36 ? 20  THR C CB  1 
ATOM   3392 O OG1 . THR C 3 20  ? 10.909  14.828  -1.508  1.00 19.98 ? 20  THR C OG1 1 
ATOM   3393 C CG2 . THR C 3 20  ? 11.112  15.627  -3.739  1.00 25.61 ? 20  THR C CG2 1 
ATOM   3394 N N   . GLY C 3 21  ? 8.055   12.987  -1.178  1.00 20.37 ? 21  GLY C N   1 
ATOM   3395 C CA  . GLY C 3 21  ? 7.584   11.829  -0.444  1.00 24.04 ? 21  GLY C CA  1 
ATOM   3396 C C   . GLY C 3 21  ? 6.558   12.229  0.599   1.00 19.46 ? 21  GLY C C   1 
ATOM   3397 O O   . GLY C 3 21  ? 6.245   13.411  0.781   1.00 23.78 ? 21  GLY C O   1 
ATOM   3398 N N   . LEU C 3 22  ? 6.031   11.222  1.296   1.00 17.75 ? 22  LEU C N   1 
ATOM   3399 C CA  . LEU C 3 22  ? 5.246   11.528  2.477   1.00 22.72 ? 22  LEU C CA  1 
ATOM   3400 C C   . LEU C 3 22  ? 5.416   10.407  3.494   1.00 21.67 ? 22  LEU C C   1 
ATOM   3401 O O   . LEU C 3 22  ? 6.094   9.407   3.239   1.00 18.21 ? 22  LEU C O   1 
ATOM   3402 C CB  . LEU C 3 22  ? 3.771   11.800  2.116   1.00 22.32 ? 22  LEU C CB  1 
ATOM   3403 C CG  . LEU C 3 22  ? 3.023   11.020  1.050   1.00 19.34 ? 22  LEU C CG  1 
ATOM   3404 C CD1 . LEU C 3 22  ? 2.861   9.636   1.620   1.00 26.78 ? 22  LEU C CD1 1 
ATOM   3405 C CD2 . LEU C 3 22  ? 1.658   11.629  0.835   1.00 24.13 ? 22  LEU C CD2 1 
ATOM   3406 N N   . ILE C 3 23  ? 4.847   10.625  4.684   1.00 19.39 ? 23  ILE C N   1 
ATOM   3407 C CA  . ILE C 3 23  ? 5.016   9.694   5.792   1.00 22.60 ? 23  ILE C CA  1 
ATOM   3408 C C   . ILE C 3 23  ? 3.667   9.504   6.487   1.00 19.19 ? 23  ILE C C   1 
ATOM   3409 O O   . ILE C 3 23  ? 2.992   10.476  6.847   1.00 19.21 ? 23  ILE C O   1 
ATOM   3410 C CB  . ILE C 3 23  ? 6.118   10.162  6.763   1.00 18.43 ? 23  ILE C CB  1 
ATOM   3411 C CG1 . ILE C 3 23  ? 6.449   9.049   7.779   1.00 23.16 ? 23  ILE C CG1 1 
ATOM   3412 C CG2 . ILE C 3 23  ? 5.751   11.481  7.419   1.00 18.25 ? 23  ILE C CG2 1 
ATOM   3413 C CD1 . ILE C 3 23  ? 7.449   9.479   8.829   1.00 23.22 ? 23  ILE C CD1 1 
ATOM   3414 N N   . LEU C 3 24  ? 3.290   8.245   6.668   1.00 17.08 ? 24  LEU C N   1 
ATOM   3415 C CA  . LEU C 3 24  ? 1.934   7.824   6.974   1.00 20.92 ? 24  LEU C CA  1 
ATOM   3416 C C   . LEU C 3 24  ? 1.938   6.968   8.228   1.00 23.86 ? 24  LEU C C   1 
ATOM   3417 O O   . LEU C 3 24  ? 2.935   6.297   8.544   1.00 18.76 ? 24  LEU C O   1 
ATOM   3418 C CB  . LEU C 3 24  ? 1.335   6.975   5.858   1.00 19.73 ? 24  LEU C CB  1 
ATOM   3419 C CG  . LEU C 3 24  ? 1.214   7.579   4.470   1.00 15.12 ? 24  LEU C CG  1 
ATOM   3420 C CD1 . LEU C 3 24  ? 0.538   6.598   3.537   1.00 18.94 ? 24  LEU C CD1 1 
ATOM   3421 C CD2 . LEU C 3 24  ? 0.387   8.800   4.631   1.00 17.90 ? 24  LEU C CD2 1 
ATOM   3422 N N   . THR C 3 25  ? 0.792   6.965   8.902   1.00 21.58 ? 25  THR C N   1 
ATOM   3423 C CA  . THR C 3 25  ? 0.469   6.013   9.962   1.00 21.64 ? 25  THR C CA  1 
ATOM   3424 C C   . THR C 3 25  ? -0.765  5.218   9.560   1.00 23.09 ? 25  THR C C   1 
ATOM   3425 O O   . THR C 3 25  ? -1.763  5.799   9.119   1.00 18.81 ? 25  THR C O   1 
ATOM   3426 C CB  . THR C 3 25  ? 0.199   6.727   11.286  1.00 18.63 ? 25  THR C CB  1 
ATOM   3427 O OG1 . THR C 3 25  ? 1.412   7.279   11.789  1.00 24.03 ? 25  THR C OG1 1 
ATOM   3428 C CG2 . THR C 3 25  ? -0.338  5.755   12.306  1.00 20.15 ? 25  THR C CG2 1 
ATOM   3429 N N   . ARG C 3 26  ? -0.713  3.894   9.749   1.00 20.20 ? 26  ARG C N   1 
ATOM   3430 C CA  . ARG C 3 26  ? -1.830  3.019   9.428   1.00 20.12 ? 26  ARG C CA  1 
ATOM   3431 C C   . ARG C 3 26  ? -2.745  2.935   10.640  1.00 22.02 ? 26  ARG C C   1 
ATOM   3432 O O   . ARG C 3 26  ? -2.274  2.736   11.767  1.00 21.17 ? 26  ARG C O   1 
ATOM   3433 C CB  . ARG C 3 26  ? -1.346  1.622   9.023   1.00 20.22 ? 26  ARG C CB  1 
ATOM   3434 C CG  . ARG C 3 26  ? -2.478  0.624   8.632   1.00 23.33 ? 26  ARG C CG  1 
ATOM   3435 C CD  . ARG C 3 26  ? -1.882  -0.722  8.227   1.00 24.65 ? 26  ARG C CD  1 
ATOM   3436 N NE  . ARG C 3 26  ? -0.984  -1.238  9.262   1.00 22.82 ? 26  ARG C NE  1 
ATOM   3437 C CZ  . ARG C 3 26  ? -1.405  -1.954  10.297  1.00 25.85 ? 26  ARG C CZ  1 
ATOM   3438 N NH1 . ARG C 3 26  ? -2.674  -2.341  10.403  1.00 21.81 ? 26  ARG C NH1 1 
ATOM   3439 N NH2 . ARG C 3 26  ? -0.542  -2.290  11.249  1.00 27.95 ? 26  ARG C NH2 1 
ATOM   3440 N N   . GLN C 3 27  ? -4.048  3.106   10.413  1.00 24.53 ? 27  GLN C N   1 
ATOM   3441 C CA  . GLN C 3 27  ? -4.976  3.142   11.538  1.00 19.80 ? 27  GLN C CA  1 
ATOM   3442 C C   . GLN C 3 27  ? -4.932  1.815   12.281  1.00 15.54 ? 27  GLN C C   1 
ATOM   3443 O O   . GLN C 3 27  ? -4.988  0.750   11.669  1.00 22.38 ? 27  GLN C O   1 
ATOM   3444 C CB  . GLN C 3 27  ? -6.396  3.426   11.055  1.00 25.65 ? 27  GLN C CB  1 
ATOM   3445 C CG  . GLN C 3 27  ? -7.421  3.437   12.209  1.00 27.24 ? 27  GLN C CG  1 
ATOM   3446 C CD  . GLN C 3 27  ? -7.887  4.834   12.542  1.00 27.73 ? 27  GLN C CD  1 
ATOM   3447 O OE1 . GLN C 3 27  ? -8.134  5.632   11.639  1.00 28.06 ? 27  GLN C OE1 1 
ATOM   3448 N NE2 . GLN C 3 27  ? -8.014  5.144   13.840  1.00 23.92 ? 27  GLN C NE2 1 
ATOM   3449 N N   . GLY C 3 28  ? -4.827  1.872   13.594  1.00 19.87 ? 28  GLY C N   1 
ATOM   3450 C CA  . GLY C 3 28  ? -4.738  0.655   14.361  1.00 19.62 ? 28  GLY C CA  1 
ATOM   3451 C C   . GLY C 3 28  ? -6.091  0.029   14.665  1.00 26.60 ? 28  GLY C C   1 
ATOM   3452 O O   . GLY C 3 28  ? -7.140  0.682   14.599  1.00 25.93 ? 28  GLY C O   1 
ATOM   3453 N N   . GLY C 3 29  ? -6.049  -1.268  14.981  1.00 21.74 ? 29  GLY C N   1 
ATOM   3454 C CA  . GLY C 3 29  ? -7.195  -1.983  15.525  1.00 25.33 ? 29  GLY C CA  1 
ATOM   3455 C C   . GLY C 3 29  ? -8.380  -2.080  14.591  1.00 34.27 ? 29  GLY C C   1 
ATOM   3456 O O   . GLY C 3 29  ? -9.535  -2.022  15.040  1.00 34.77 ? 29  GLY C O   1 
ATOM   3457 N N   . TYR C 3 30  ? -8.113  -2.136  13.286  1.00 29.99 ? 30  TYR C N   1 
ATOM   3458 C CA  . TYR C 3 30  ? -9.236  -2.112  12.311  1.00 36.73 ? 30  TYR C CA  1 
ATOM   3459 C C   . TYR C 3 30  ? -9.718  -3.531  12.046  1.00 43.20 ? 30  TYR C C   1 
ATOM   3460 O O   . TYR C 3 30  ? -8.876  -4.423  11.815  1.00 40.41 ? 30  TYR C O   1 
ATOM   3461 C CB  . TYR C 3 30  ? -8.764  -1.403  11.037  1.00 42.10 ? 30  TYR C CB  1 
ATOM   3462 C CG  . TYR C 3 30  ? -9.858  -1.071  10.030  1.00 47.07 ? 30  TYR C CG  1 
ATOM   3463 C CD1 . TYR C 3 30  ? -11.197 -1.045  10.400  1.00 41.83 ? 30  TYR C CD1 1 
ATOM   3464 C CD2 . TYR C 3 30  ? -9.548  -0.772  8.710   1.00 44.49 ? 30  TYR C CD2 1 
ATOM   3465 C CE1 . TYR C 3 30  ? -12.194 -0.751  9.486   1.00 43.07 ? 30  TYR C CE1 1 
ATOM   3466 C CE2 . TYR C 3 30  ? -10.535 -0.472  7.788   1.00 38.81 ? 30  TYR C CE2 1 
ATOM   3467 C CZ  . TYR C 3 30  ? -11.862 -0.461  8.176   1.00 43.94 ? 30  TYR C CZ  1 
ATOM   3468 O OH  . TYR C 3 30  ? -12.839 -0.162  7.272   1.00 46.64 ? 30  TYR C OH  1 
ATOM   3469 N N   . SER C 3 31  ? -11.037 -3.744  12.086  1.00 46.78 ? 31  SER C N   1 
ATOM   3470 C CA  . SER C 3 31  ? -11.588 -5.073  11.720  1.00 46.87 ? 31  SER C CA  1 
ATOM   3471 C C   . SER C 3 31  ? -11.168 -5.367  10.280  1.00 53.07 ? 31  SER C C   1 
ATOM   3472 O O   . SER C 3 31  ? -11.022 -6.563  9.957   1.00 46.18 ? 31  SER C O   1 
ATOM   3473 C CB  . SER C 3 31  ? -13.081 -5.092  11.864  1.00 47.57 ? 31  SER C CB  1 
ATOM   3474 O OG  . SER C 3 31  ? -13.676 -4.135  11.001  1.00 60.55 ? 31  SER C OG  1 
ATOM   3475 N N   . ASN C 3 32  ? -11.010 -4.320  9.461   1.00 54.68 ? 32  ASN C N   1 
ATOM   3476 C CA  . ASN C 3 32  ? -10.534 -4.463  8.057   1.00 49.88 ? 32  ASN C CA  1 
ATOM   3477 C C   . ASN C 3 32  ? -11.588 -5.143  7.181   1.00 53.98 ? 32  ASN C C   1 
ATOM   3478 O O   . ASN C 3 32  ? -11.580 -6.385  7.111   1.00 50.18 ? 32  ASN C O   1 
ATOM   3479 C CB  . ASN C 3 32  ? -9.193  -5.197  7.958   1.00 57.54 ? 32  ASN C CB  1 
ATOM   3480 C CG  . ASN C 3 32  ? -8.084  -4.502  8.716   1.00 50.02 ? 32  ASN C CG  1 
ATOM   3481 O OD1 . ASN C 3 32  ? -7.755  -3.355  8.428   1.00 29.94 ? 32  ASN C OD1 1 
ATOM   3482 N ND2 . ASN C 3 32  ? -7.502  -5.190  9.684   1.00 58.20 ? 32  ASN C ND2 1 
ATOM   3483 N N   . ALA C 3 33  ? -12.466 -4.364  6.548   1.00 56.14 ? 33  ALA C N   1 
ATOM   3484 C CA  . ALA C 3 33  ? -13.402 -4.962  5.571   1.00 48.42 ? 33  ALA C CA  1 
ATOM   3485 C C   . ALA C 3 33  ? -12.667 -4.928  4.232   1.00 56.14 ? 33  ALA C C   1 
ATOM   3486 O O   . ALA C 3 33  ? -13.100 -4.161  3.349   1.00 63.28 ? 33  ALA C O   1 
ATOM   3487 C CB  . ALA C 3 33  ? -14.686 -4.177  5.530   1.00 49.20 ? 33  ALA C CB  1 
ATOM   3488 N N   . ASN C 3 34  ? -11.595 -5.717  4.094   1.00 55.59 ? 34  ASN C N   1 
ATOM   3489 C CA  . ASN C 3 34  ? -10.743 -5.614  2.879   1.00 48.70 ? 34  ASN C CA  1 
ATOM   3490 C C   . ASN C 3 34  ? -10.364 -4.138  2.766   1.00 45.43 ? 34  ASN C C   1 
ATOM   3491 O O   . ASN C 3 34  ? -10.156 -3.660  1.633   1.00 49.60 ? 34  ASN C O   1 
ATOM   3492 C CB  . ASN C 3 34  ? -11.415 -6.183  1.627   1.00 52.62 ? 34  ASN C CB  1 
ATOM   3493 C CG  . ASN C 3 34  ? -10.590 -7.277  0.985   1.00 61.24 ? 34  ASN C CG  1 
ATOM   3494 O OD1 . ASN C 3 34  ? -9.387  -7.120  0.793   1.00 62.69 ? 34  ASN C OD1 1 
ATOM   3495 N ND2 . ASN C 3 34  ? -11.226 -8.390  0.657   1.00 62.04 ? 34  ASN C ND2 1 
ATOM   3496 N N   . THR C 3 35  ? -10.279 -3.452  3.913   1.00 41.37 ? 35  THR C N   1 
ATOM   3497 C CA  . THR C 3 35  ? -10.021 -2.026  3.875   1.00 37.84 ? 35  THR C CA  1 
ATOM   3498 C C   . THR C 3 35  ? -8.858  -1.698  4.795   1.00 37.61 ? 35  THR C C   1 
ATOM   3499 O O   . THR C 3 35  ? -8.753  -2.252  5.893   1.00 34.67 ? 35  THR C O   1 
ATOM   3500 C CB  . THR C 3 35  ? -11.267 -1.259  4.326   1.00 43.44 ? 35  THR C CB  1 
ATOM   3501 O OG1 . THR C 3 35  ? -12.396 -1.725  3.579   1.00 44.02 ? 35  THR C OG1 1 
ATOM   3502 C CG2 . THR C 3 35  ? -11.101 0.252   4.136   1.00 33.71 ? 35  THR C CG2 1 
ATOM   3503 N N   . VAL C 3 36  ? -7.991  -0.790  4.348   1.00 34.76 ? 36  VAL C N   1 
ATOM   3504 C CA  . VAL C 3 36  ? -6.881  -0.302  5.156   1.00 30.51 ? 36  VAL C CA  1 
ATOM   3505 C C   . VAL C 3 36  ? -6.887  1.215   5.117   1.00 20.93 ? 36  VAL C C   1 
ATOM   3506 O O   . VAL C 3 36  ? -7.017  1.816   4.042   1.00 23.86 ? 36  VAL C O   1 
ATOM   3507 C CB  . VAL C 3 36  ? -5.530  -0.851  4.674   1.00 27.44 ? 36  VAL C CB  1 
ATOM   3508 C CG1 . VAL C 3 36  ? -4.484  -0.487  5.679   1.00 25.61 ? 36  VAL C CG1 1 
ATOM   3509 C CG2 . VAL C 3 36  ? -5.616  -2.346  4.510   1.00 30.25 ? 36  VAL C CG2 1 
ATOM   3510 N N   . ILE C 3 37  ? -6.752  1.827   6.282   1.00 20.99 ? 37  ILE C N   1 
ATOM   3511 C CA  . ILE C 3 37  ? -6.861  3.270   6.457   1.00 21.09 ? 37  ILE C CA  1 
ATOM   3512 C C   . ILE C 3 37  ? -5.484  3.815   6.805   1.00 22.56 ? 37  ILE C C   1 
ATOM   3513 O O   . ILE C 3 37  ? -4.756  3.208   7.603   1.00 21.46 ? 37  ILE C O   1 
ATOM   3514 C CB  . ILE C 3 37  ? -7.891  3.596   7.565   1.00 25.70 ? 37  ILE C CB  1 
ATOM   3515 C CG1 . ILE C 3 37  ? -9.282  3.061   7.203   1.00 25.33 ? 37  ILE C CG1 1 
ATOM   3516 C CG2 . ILE C 3 37  ? -7.898  5.085   7.947   1.00 19.47 ? 37  ILE C CG2 1 
ATOM   3517 C CD1 . ILE C 3 37  ? -10.274 3.169   8.361   1.00 29.25 ? 37  ILE C CD1 1 
ATOM   3518 N N   . PHE C 3 38  ? -5.116  4.949   6.187   1.00 17.51 ? 38  PHE C N   1 
ATOM   3519 C CA  . PHE C 3 38  ? -3.858  5.635   6.466   1.00 21.34 ? 38  PHE C CA  1 
ATOM   3520 C C   . PHE C 3 38  ? -4.115  7.122   6.672   1.00 24.51 ? 38  PHE C C   1 
ATOM   3521 O O   . PHE C 3 38  ? -4.999  7.705   6.041   1.00 20.44 ? 38  PHE C O   1 
ATOM   3522 C CB  . PHE C 3 38  ? -2.849  5.463   5.333   1.00 15.20 ? 38  PHE C CB  1 
ATOM   3523 C CG  . PHE C 3 38  ? -2.516  4.044   5.040   1.00 21.55 ? 38  PHE C CG  1 
ATOM   3524 C CD1 . PHE C 3 38  ? -3.311  3.292   4.181   1.00 19.26 ? 38  PHE C CD1 1 
ATOM   3525 C CD2 . PHE C 3 38  ? -1.392  3.450   5.620   1.00 20.21 ? 38  PHE C CD2 1 
ATOM   3526 C CE1 . PHE C 3 38  ? -2.996  1.996   3.900   1.00 25.52 ? 38  PHE C CE1 1 
ATOM   3527 C CE2 . PHE C 3 38  ? -1.089  2.139   5.361   1.00 20.27 ? 38  PHE C CE2 1 
ATOM   3528 C CZ  . PHE C 3 38  ? -1.871  1.411   4.488   1.00 19.33 ? 38  PHE C CZ  1 
ATOM   3529 N N   . ARG C 3 39  ? -3.332  7.719   7.566   1.00 16.13 ? 39  ARG C N   1 
ATOM   3530 C CA  . ARG C 3 39  ? -3.349  9.125   7.926   1.00 18.72 ? 39  ARG C CA  1 
ATOM   3531 C C   . ARG C 3 39  ? -1.920  9.659   7.834   1.00 20.36 ? 39  ARG C C   1 
ATOM   3532 O O   . ARG C 3 39  ? -0.972  8.875   7.847   1.00 19.26 ? 39  ARG C O   1 
ATOM   3533 C CB  . ARG C 3 39  ? -3.872  9.329   9.355   1.00 18.70 ? 39  ARG C CB  1 
ATOM   3534 C CG  . ARG C 3 39  ? -5.253  8.735   9.600   1.00 20.83 ? 39  ARG C CG  1 
ATOM   3535 C CD  . ARG C 3 39  ? -5.681  8.884   11.062  1.00 18.35 ? 39  ARG C CD  1 
ATOM   3536 N NE  . ARG C 3 39  ? -6.975  8.244   11.276  1.00 21.10 ? 39  ARG C NE  1 
ATOM   3537 C CZ  . ARG C 3 39  ? -8.144  8.879   11.185  1.00 26.08 ? 39  ARG C CZ  1 
ATOM   3538 N NH1 . ARG C 3 39  ? -8.214  10.177  10.904  1.00 19.72 ? 39  ARG C NH1 1 
ATOM   3539 N NH2 . ARG C 3 39  ? -9.268  8.203   11.399  1.00 25.94 ? 39  ARG C NH2 1 
ATOM   3540 N N   . PRO C 3 40  ? -1.746  10.979  7.739   1.00 21.61 ? 40  PRO C N   1 
ATOM   3541 C CA  . PRO C 3 40  ? -0.394  11.527  7.913   1.00 22.11 ? 40  PRO C CA  1 
ATOM   3542 C C   . PRO C 3 40  ? 0.127   11.086  9.270   1.00 27.86 ? 40  PRO C C   1 
ATOM   3543 O O   . PRO C 3 40  ? -0.647  10.894  10.220  1.00 18.26 ? 40  PRO C O   1 
ATOM   3544 C CB  . PRO C 3 40  ? -0.590  13.044  7.823   1.00 22.28 ? 40  PRO C CB  1 
ATOM   3545 C CG  . PRO C 3 40  ? -2.107  13.273  8.041   1.00 22.68 ? 40  PRO C CG  1 
ATOM   3546 C CD  . PRO C 3 40  ? -2.766  12.024  7.531   1.00 20.78 ? 40  PRO C CD  1 
ATOM   3547 N N   . SER C 3 41  ? 1.447   10.861  9.323   1.00 22.66 ? 41  SER C N   1 
ATOM   3548 C CA  . SER C 3 41  ? 2.061   10.113  10.416  1.00 20.62 ? 41  SER C CA  1 
ATOM   3549 C C   . SER C 3 41  ? 1.704   10.684  11.775  1.00 21.61 ? 41  SER C C   1 
ATOM   3550 O O   . SER C 3 41  ? 1.753   11.895  11.996  1.00 20.49 ? 41  SER C O   1 
ATOM   3551 C CB  . SER C 3 41  ? 3.590   10.089  10.280  1.00 23.44 ? 41  SER C CB  1 
ATOM   3552 O OG  . SER C 3 41  ? 4.166   9.465   11.443  1.00 24.32 ? 41  SER C OG  1 
ATOM   3553 N N   . GLY C 3 42  ? 1.387   9.782   12.710  1.00 22.33 ? 42  GLY C N   1 
ATOM   3554 C CA  . GLY C 3 42  ? 1.273   10.193  14.097  1.00 21.05 ? 42  GLY C CA  1 
ATOM   3555 C C   . GLY C 3 42  ? 2.580   10.243  14.850  1.00 23.68 ? 42  GLY C C   1 
ATOM   3556 O O   . GLY C 3 42  ? 2.572   10.548  16.052  1.00 23.99 ? 42  GLY C O   1 
ATOM   3557 N N   . GLY C 3 43  ? 3.704   9.958   14.178  1.00 21.29 ? 43  GLY C N   1 
ATOM   3558 C CA  . GLY C 3 43  ? 5.019   10.019  14.785  1.00 24.26 ? 43  GLY C CA  1 
ATOM   3559 C C   . GLY C 3 43  ? 5.600   11.429  14.800  1.00 25.56 ? 43  GLY C C   1 
ATOM   3560 O O   . GLY C 3 43  ? 4.936   12.416  14.473  1.00 28.13 ? 43  GLY C O   1 
ATOM   3561 N N   . ASP C 3 44  ? 6.881   11.513  15.192  1.00 22.11 ? 44  ASP C N   1 
ATOM   3562 C CA  . ASP C 3 44  ? 7.564   12.785  15.424  1.00 20.44 ? 44  ASP C CA  1 
ATOM   3563 C C   . ASP C 3 44  ? 8.739   12.950  14.459  1.00 24.46 ? 44  ASP C C   1 
ATOM   3564 O O   . ASP C 3 44  ? 8.769   12.316  13.398  1.00 21.15 ? 44  ASP C O   1 
ATOM   3565 C CB  . ASP C 3 44  ? 8.027   12.909  16.879  1.00 24.27 ? 44  ASP C CB  1 
ATOM   3566 C CG  . ASP C 3 44  ? 8.930   11.773  17.297  1.00 24.06 ? 44  ASP C CG  1 
ATOM   3567 O OD1 . ASP C 3 44  ? 9.614   11.194  16.431  1.00 27.60 ? 44  ASP C OD1 1 
ATOM   3568 O OD2 . ASP C 3 44  ? 8.923   11.424  18.490  1.00 29.70 ? 44  ASP C OD2 1 
ATOM   3569 N N   . TRP C 3 45  ? 9.651   13.879  14.764  1.00 26.09 ? 45  TRP C N   1 
ATOM   3570 C CA  . TRP C 3 45  ? 10.809  14.103  13.896  1.00 26.70 ? 45  TRP C CA  1 
ATOM   3571 C C   . TRP C 3 45  ? 11.650  12.854  13.709  1.00 28.46 ? 45  TRP C C   1 
ATOM   3572 O O   . TRP C 3 45  ? 12.284  12.689  12.663  1.00 25.03 ? 45  TRP C O   1 
ATOM   3573 C CB  . TRP C 3 45  ? 11.677  15.213  14.462  1.00 23.96 ? 45  TRP C CB  1 
ATOM   3574 C CG  . TRP C 3 45  ? 10.913  16.456  14.726  1.00 24.01 ? 45  TRP C CG  1 
ATOM   3575 C CD1 . TRP C 3 45  ? 10.531  16.939  15.936  1.00 28.32 ? 45  TRP C CD1 1 
ATOM   3576 C CD2 . TRP C 3 45  ? 10.438  17.386  13.748  1.00 24.23 ? 45  TRP C CD2 1 
ATOM   3577 N NE1 . TRP C 3 45  ? 9.850   18.119  15.775  1.00 31.11 ? 45  TRP C NE1 1 
ATOM   3578 C CE2 . TRP C 3 45  ? 9.779   18.413  14.438  1.00 30.09 ? 45  TRP C CE2 1 
ATOM   3579 C CE3 . TRP C 3 45  ? 10.518  17.450  12.355  1.00 26.43 ? 45  TRP C CE3 1 
ATOM   3580 C CZ2 . TRP C 3 45  ? 9.183   19.495  13.778  1.00 33.43 ? 45  TRP C CZ2 1 
ATOM   3581 C CZ3 . TRP C 3 45  ? 9.927   18.504  11.704  1.00 27.02 ? 45  TRP C CZ3 1 
ATOM   3582 C CH2 . TRP C 3 45  ? 9.277   19.523  12.413  1.00 28.52 ? 45  TRP C CH2 1 
ATOM   3583 N N   . ARG C 3 46  ? 11.707  11.983  14.712  1.00 25.58 ? 46  ARG C N   1 
ATOM   3584 C CA  . ARG C 3 46  ? 12.489  10.769  14.547  1.00 25.98 ? 46  ARG C CA  1 
ATOM   3585 C C   . ARG C 3 46  ? 11.892  9.873   13.479  1.00 24.46 ? 46  ARG C C   1 
ATOM   3586 O O   . ARG C 3 46  ? 12.633  9.299   12.674  1.00 26.18 ? 46  ARG C O   1 
ATOM   3587 C CB  . ARG C 3 46  ? 12.627  10.035  15.891  1.00 31.21 ? 46  ARG C CB  1 
ATOM   3588 C CG  . ARG C 3 46  ? 13.621  10.763  16.815  1.00 40.15 ? 46  ARG C CG  1 
ATOM   3589 C CD  . ARG C 3 46  ? 13.670  10.246  18.260  1.00 44.81 ? 46  ARG C CD  1 
ATOM   3590 N NE  . ARG C 3 46  ? 14.460  11.149  19.096  1.00 62.65 ? 46  ARG C NE  1 
ATOM   3591 C CZ  . ARG C 3 46  ? 13.971  12.050  19.948  1.00 62.58 ? 46  ARG C CZ  1 
ATOM   3592 N NH1 . ARG C 3 46  ? 12.675  12.127  20.222  1.00 50.36 ? 46  ARG C NH1 1 
ATOM   3593 N NH2 . ARG C 3 46  ? 14.808  12.897  20.543  1.00 58.35 ? 46  ARG C NH2 1 
ATOM   3594 N N   . ASP C 3 47  ? 10.554  9.745   13.437  1.00 25.03 ? 47  ASP C N   1 
ATOM   3595 C CA  . ASP C 3 47  ? 9.931   8.950   12.370  1.00 27.68 ? 47  ASP C CA  1 
ATOM   3596 C C   . ASP C 3 47  ? 10.312  9.507   11.001  1.00 20.70 ? 47  ASP C C   1 
ATOM   3597 O O   . ASP C 3 47  ? 10.633  8.752   10.073  1.00 21.38 ? 47  ASP C O   1 
ATOM   3598 C CB  . ASP C 3 47  ? 8.394   8.926   12.505  1.00 21.16 ? 47  ASP C CB  1 
ATOM   3599 C CG  . ASP C 3 47  ? 7.893   8.115   13.711  1.00 25.68 ? 47  ASP C CG  1 
ATOM   3600 O OD1 . ASP C 3 47  ? 7.965   8.646   14.840  1.00 20.06 ? 47  ASP C OD1 1 
ATOM   3601 O OD2 . ASP C 3 47  ? 7.394   6.964   13.511  1.00 27.32 ? 47  ASP C OD2 1 
ATOM   3602 N N   . ILE C 3 48  ? 10.239  10.836  10.861  1.00 24.15 ? 48  ILE C N   1 
ATOM   3603 C CA  . ILE C 3 48  ? 10.620  11.506  9.616   1.00 23.73 ? 48  ILE C CA  1 
ATOM   3604 C C   . ILE C 3 48  ? 12.080  11.203  9.271   1.00 23.86 ? 48  ILE C C   1 
ATOM   3605 O O   . ILE C 3 48  ? 12.394  10.740  8.166   1.00 20.55 ? 48  ILE C O   1 
ATOM   3606 C CB  . ILE C 3 48  ? 10.371  13.021  9.741   1.00 20.68 ? 48  ILE C CB  1 
ATOM   3607 C CG1 . ILE C 3 48  ? 8.867   13.334  9.932   1.00 19.67 ? 48  ILE C CG1 1 
ATOM   3608 C CG2 . ILE C 3 48  ? 10.972  13.788  8.548   1.00 23.10 ? 48  ILE C CG2 1 
ATOM   3609 C CD1 . ILE C 3 48  ? 8.589   14.803  10.368  1.00 17.23 ? 48  ILE C CD1 1 
ATOM   3610 N N   . ALA C 3 49  ? 12.986  11.402  10.238  1.00 22.87 ? 49  ALA C N   1 
ATOM   3611 C CA  . ALA C 3 49  ? 14.415  11.202  9.970   1.00 21.52 ? 49  ALA C CA  1 
ATOM   3612 C C   . ALA C 3 49  ? 14.715  9.774   9.541   1.00 24.61 ? 49  ALA C C   1 
ATOM   3613 O O   . ALA C 3 49  ? 15.501  9.543   8.613   1.00 21.83 ? 49  ALA C O   1 
ATOM   3614 C CB  . ALA C 3 49  ? 15.221  11.566  11.216  1.00 28.60 ? 49  ALA C CB  1 
ATOM   3615 N N   . ARG C 3 50  ? 14.081  8.797   10.186  1.00 19.94 ? 50  ARG C N   1 
ATOM   3616 C CA  . ARG C 3 50  ? 14.381  7.399   9.898   1.00 20.30 ? 50  ARG C CA  1 
ATOM   3617 C C   . ARG C 3 50  ? 14.031  6.996   8.472   1.00 22.18 ? 50  ARG C C   1 
ATOM   3618 O O   . ARG C 3 50  ? 14.590  6.018   7.960   1.00 22.23 ? 50  ARG C O   1 
ATOM   3619 C CB  . ARG C 3 50  ? 13.645  6.502   10.897  1.00 26.94 ? 50  ARG C CB  1 
ATOM   3620 C CG  . ARG C 3 50  ? 14.215  6.617   12.314  1.00 31.88 ? 50  ARG C CG  1 
ATOM   3621 C CD  . ARG C 3 50  ? 13.538  5.647   13.258  1.00 31.93 ? 50  ARG C CD  1 
ATOM   3622 N NE  . ARG C 3 50  ? 14.005  4.279   13.082  1.00 41.84 ? 50  ARG C NE  1 
ATOM   3623 C CZ  . ARG C 3 50  ? 15.018  3.750   13.757  1.00 38.71 ? 50  ARG C CZ  1 
ATOM   3624 N NH1 . ARG C 3 50  ? 15.717  4.463   14.626  1.00 38.17 ? 50  ARG C NH1 1 
ATOM   3625 N NH2 . ARG C 3 50  ? 15.334  2.478   13.558  1.00 42.62 ? 50  ARG C NH2 1 
ATOM   3626 N N   . CYS C 3 51  ? 13.072  7.685   7.831   1.00 24.69 ? 51  CYS C N   1 
ATOM   3627 C CA  . CYS C 3 51  ? 12.799  7.427   6.415   1.00 18.85 ? 51  CYS C CA  1 
ATOM   3628 C C   . CYS C 3 51  ? 14.029  7.689   5.536   1.00 18.71 ? 51  CYS C C   1 
ATOM   3629 O O   . CYS C 3 51  ? 14.191  7.046   4.491   1.00 22.63 ? 51  CYS C O   1 
ATOM   3630 C CB  . CYS C 3 51  ? 11.627  8.294   5.925   1.00 22.23 ? 51  CYS C CB  1 
ATOM   3631 S SG  . CYS C 3 51  ? 10.032  7.898   6.704   1.00 23.57 ? 51  CYS C SG  1 
ATOM   3632 N N   . GLN C 3 52  ? 14.892  8.617   5.938   1.00 18.00 ? 52  GLN C N   1 
ATOM   3633 C CA  . GLN C 3 52  ? 16.118  8.926   5.196   1.00 25.69 ? 52  GLN C CA  1 
ATOM   3634 C C   . GLN C 3 52  ? 15.812  9.275   3.748   1.00 25.31 ? 52  GLN C C   1 
ATOM   3635 O O   . GLN C 3 52  ? 16.522  8.868   2.824   1.00 23.22 ? 52  GLN C O   1 
ATOM   3636 C CB  . GLN C 3 52  ? 17.131  7.775   5.256   1.00 26.05 ? 52  GLN C CB  1 
ATOM   3637 C CG  . GLN C 3 52  ? 17.711  7.476   6.631   1.00 27.46 ? 52  GLN C CG  1 
ATOM   3638 C CD  . GLN C 3 52  ? 18.888  6.507   6.528   1.00 33.66 ? 52  GLN C CD  1 
ATOM   3639 O OE1 . GLN C 3 52  ? 19.897  6.803   5.865   1.00 31.17 ? 52  GLN C OE1 1 
ATOM   3640 N NE2 . GLN C 3 52  ? 18.746  5.334   7.136   1.00 33.60 ? 52  GLN C NE2 1 
ATOM   3641 N N   . ILE C 3 53  ? 14.754  10.069  3.536   1.00 22.92 ? 53  ILE C N   1 
ATOM   3642 C CA  . ILE C 3 53  ? 14.503  10.625  2.215   1.00 20.67 ? 53  ILE C CA  1 
ATOM   3643 C C   . ILE C 3 53  ? 14.336  12.136  2.237   1.00 23.28 ? 53  ILE C C   1 
ATOM   3644 O O   . ILE C 3 53  ? 14.022  12.729  1.201   1.00 22.87 ? 53  ILE C O   1 
ATOM   3645 C CB  . ILE C 3 53  ? 13.300  9.969   1.516   1.00 19.85 ? 53  ILE C CB  1 
ATOM   3646 C CG1 . ILE C 3 53  ? 12.000  10.209  2.309   1.00 22.33 ? 53  ILE C CG1 1 
ATOM   3647 C CG2 . ILE C 3 53  ? 13.613  8.527   1.214   1.00 19.99 ? 53  ILE C CG2 1 
ATOM   3648 C CD1 . ILE C 3 53  ? 10.766  9.761   1.527   1.00 20.75 ? 53  ILE C CD1 1 
ATOM   3649 N N   . ALA C 3 54  ? 14.532  12.771  3.379   1.00 20.27 ? 54  ALA C N   1 
ATOM   3650 C CA  . ALA C 3 54  ? 14.498  14.215  3.448   1.00 22.62 ? 54  ALA C CA  1 
ATOM   3651 C C   . ALA C 3 54  ? 15.737  14.820  2.785   1.00 23.90 ? 54  ALA C C   1 
ATOM   3652 O O   . ALA C 3 54  ? 16.750  14.154  2.531   1.00 23.92 ? 54  ALA C O   1 
ATOM   3653 C CB  . ALA C 3 54  ? 14.419  14.691  4.903   1.00 19.49 ? 54  ALA C CB  1 
ATOM   3654 N N   . GLY C 3 55  ? 15.629  16.114  2.511   1.00 22.36 ? 55  GLY C N   1 
ATOM   3655 C CA  . GLY C 3 55  ? 16.710  16.930  2.009   1.00 27.39 ? 55  GLY C CA  1 
ATOM   3656 C C   . GLY C 3 55  ? 17.068  17.923  3.085   1.00 21.23 ? 55  GLY C C   1 
ATOM   3657 O O   . GLY C 3 55  ? 16.951  17.618  4.271   1.00 21.62 ? 55  GLY C O   1 
ATOM   3658 N N   . THR C 3 56  ? 17.468  19.125  2.690   1.00 19.41 ? 56  THR C N   1 
ATOM   3659 C CA  . THR C 3 56  ? 17.793  20.149  3.673   1.00 20.75 ? 56  THR C CA  1 
ATOM   3660 C C   . THR C 3 56  ? 16.556  20.627  4.435   1.00 22.79 ? 56  THR C C   1 
ATOM   3661 O O   . THR C 3 56  ? 16.625  20.849  5.656   1.00 18.54 ? 56  THR C O   1 
ATOM   3662 C CB  . THR C 3 56  ? 18.472  21.325  2.968   1.00 20.90 ? 56  THR C CB  1 
ATOM   3663 O OG1 . THR C 3 56  ? 19.557  20.837  2.167   1.00 21.63 ? 56  THR C OG1 1 
ATOM   3664 C CG2 . THR C 3 56  ? 18.958  22.370  3.966   1.00 19.48 ? 56  THR C CG2 1 
ATOM   3665 N N   . VAL C 3 57  ? 15.414  20.773  3.736   1.00 21.95 ? 57  VAL C N   1 
ATOM   3666 C CA  . VAL C 3 57  ? 14.218  21.401  4.302   1.00 20.11 ? 57  VAL C CA  1 
ATOM   3667 C C   . VAL C 3 57  ? 13.633  20.488  5.380   1.00 19.75 ? 57  VAL C C   1 
ATOM   3668 O O   . VAL C 3 57  ? 13.523  19.279  5.181   1.00 21.70 ? 57  VAL C O   1 
ATOM   3669 C CB  . VAL C 3 57  ? 13.165  21.667  3.203   1.00 20.85 ? 57  VAL C CB  1 
ATOM   3670 C CG1 . VAL C 3 57  ? 11.820  22.144  3.840   1.00 20.65 ? 57  VAL C CG1 1 
ATOM   3671 C CG2 . VAL C 3 57  ? 13.656  22.705  2.150   1.00 20.81 ? 57  VAL C CG2 1 
ATOM   3672 N N   . VAL C 3 58  ? 13.254  21.065  6.514   1.00 19.41 ? 58  VAL C N   1 
ATOM   3673 C CA  . VAL C 3 58  ? 12.581  20.329  7.582   1.00 21.47 ? 58  VAL C CA  1 
ATOM   3674 C C   . VAL C 3 58  ? 11.076  20.453  7.331   1.00 21.50 ? 58  VAL C C   1 
ATOM   3675 O O   . VAL C 3 58  ? 10.546  21.563  7.243   1.00 19.33 ? 58  VAL C O   1 
ATOM   3676 C CB  . VAL C 3 58  ? 12.958  20.908  8.956   1.00 24.04 ? 58  VAL C CB  1 
ATOM   3677 C CG1 . VAL C 3 58  ? 12.065  20.357  10.052  1.00 24.99 ? 58  VAL C CG1 1 
ATOM   3678 C CG2 . VAL C 3 58  ? 14.448  20.644  9.262   1.00 26.40 ? 58  VAL C CG2 1 
ATOM   3679 N N   . SER C 3 59  ? 10.388  19.327  7.185   1.00 25.45 ? 59  SER C N   1 
ATOM   3680 C CA  . SER C 3 59  ? 8.955   19.397  6.937   1.00 17.29 ? 59  SER C CA  1 
ATOM   3681 C C   . SER C 3 59  ? 8.285   18.170  7.537   1.00 26.60 ? 59  SER C C   1 
ATOM   3682 O O   . SER C 3 59  ? 8.933   17.145  7.770   1.00 21.75 ? 59  SER C O   1 
ATOM   3683 C CB  . SER C 3 59  ? 8.672   19.514  5.439   1.00 15.89 ? 59  SER C CB  1 
ATOM   3684 O OG  . SER C 3 59  ? 9.075   18.332  4.780   1.00 18.40 ? 59  SER C OG  1 
ATOM   3685 N N   . THR C 3 60  ? 6.969   18.283  7.780   1.00 24.46 ? 60  THR C N   1 
ATOM   3686 C CA  . THR C 3 60  ? 6.150   17.190  8.299   1.00 23.17 ? 60  THR C CA  1 
ATOM   3687 C C   . THR C 3 60  ? 5.062   16.787  7.309   1.00 24.77 ? 60  THR C C   1 
ATOM   3688 O O   . THR C 3 60  ? 4.609   17.580  6.473   1.00 22.38 ? 60  THR C O   1 
ATOM   3689 C CB  . THR C 3 60  ? 5.467   17.547  9.629   1.00 20.26 ? 60  THR C CB  1 
ATOM   3690 O OG1 . THR C 3 60  ? 4.506   18.578  9.396   1.00 20.47 ? 60  THR C OG1 1 
ATOM   3691 C CG2 . THR C 3 60  ? 6.498   18.037  10.680  1.00 19.55 ? 60  THR C CG2 1 
ATOM   3692 N N   . GLN C 3 61  ? 4.709   15.509  7.402   1.00 17.97 ? 61  GLN C N   1 
ATOM   3693 C CA  . GLN C 3 61  ? 3.722   14.745  6.657   1.00 21.75 ? 61  GLN C CA  1 
ATOM   3694 C C   . GLN C 3 61  ? 4.095   14.620  5.194   1.00 18.70 ? 61  GLN C C   1 
ATOM   3695 O O   . GLN C 3 61  ? 3.975   13.541  4.619   1.00 20.15 ? 61  GLN C O   1 
ATOM   3696 C CB  . GLN C 3 61  ? 2.323   15.400  6.708   1.00 19.40 ? 61  GLN C CB  1 
ATOM   3697 C CG  . GLN C 3 61  ? 1.824   15.967  8.031   1.00 17.60 ? 61  GLN C CG  1 
ATOM   3698 C CD  . GLN C 3 61  ? 0.341   16.394  7.899   1.00 23.38 ? 61  GLN C CD  1 
ATOM   3699 O OE1 . GLN C 3 61  ? -0.182  16.537  6.781   1.00 17.38 ? 61  GLN C OE1 1 
ATOM   3700 N NE2 . GLN C 3 61  ? -0.328  16.583  9.023   1.00 20.41 ? 61  GLN C NE2 1 
ATOM   3701 N N   . LEU C 3 62  ? 4.704   15.653  4.632   1.00 20.31 ? 62  LEU C N   1 
ATOM   3702 C CA  . LEU C 3 62  ? 5.154   15.614  3.248   1.00 22.00 ? 62  LEU C CA  1 
ATOM   3703 C C   . LEU C 3 62  ? 6.636   15.916  3.289   1.00 15.01 ? 62  LEU C C   1 
ATOM   3704 O O   . LEU C 3 62  ? 7.048   16.833  3.994   1.00 19.44 ? 62  LEU C O   1 
ATOM   3705 C CB  . LEU C 3 62  ? 4.444   16.660  2.338   1.00 18.69 ? 62  LEU C CB  1 
ATOM   3706 C CG  . LEU C 3 62  ? 2.904   16.684  2.310   1.00 20.96 ? 62  LEU C CG  1 
ATOM   3707 C CD1 . LEU C 3 62  ? 2.419   17.845  1.439   1.00 23.02 ? 62  LEU C CD1 1 
ATOM   3708 C CD2 . LEU C 3 62  ? 2.334   15.377  1.806   1.00 16.93 ? 62  LEU C CD2 1 
ATOM   3709 N N   . PHE C 3 63  ? 7.431   15.161  2.549   1.00 19.99 ? 63  PHE C N   1 
ATOM   3710 C CA  . PHE C 3 63  ? 8.831   15.551  2.389   1.00 21.74 ? 63  PHE C CA  1 
ATOM   3711 C C   . PHE C 3 63  ? 8.910   16.582  1.269   1.00 19.33 ? 63  PHE C C   1 
ATOM   3712 O O   . PHE C 3 63  ? 8.392   16.355  0.175   1.00 20.96 ? 63  PHE C O   1 
ATOM   3713 C CB  . PHE C 3 63  ? 9.714   14.344  2.062   1.00 21.68 ? 63  PHE C CB  1 
ATOM   3714 C CG  . PHE C 3 63  ? 9.761   13.296  3.149   1.00 20.24 ? 63  PHE C CG  1 
ATOM   3715 C CD1 . PHE C 3 63  ? 10.648  13.412  4.218   1.00 24.59 ? 63  PHE C CD1 1 
ATOM   3716 C CD2 . PHE C 3 63  ? 8.950   12.177  3.079   1.00 21.80 ? 63  PHE C CD2 1 
ATOM   3717 C CE1 . PHE C 3 63  ? 10.691  12.443  5.211   1.00 26.52 ? 63  PHE C CE1 1 
ATOM   3718 C CE2 . PHE C 3 63  ? 8.983   11.191  4.077   1.00 24.73 ? 63  PHE C CE2 1 
ATOM   3719 C CZ  . PHE C 3 63  ? 9.843   11.321  5.143   1.00 20.53 ? 63  PHE C CZ  1 
ATOM   3720 N N   . LEU C 3 64  ? 9.544   17.708  1.542   1.00 14.58 ? 64  LEU C N   1 
ATOM   3721 C CA  . LEU C 3 64  ? 9.735   18.757  0.555   1.00 20.32 ? 64  LEU C CA  1 
ATOM   3722 C C   . LEU C 3 64  ? 11.203  18.807  0.156   1.00 21.36 ? 64  LEU C C   1 
ATOM   3723 O O   . LEU C 3 64  ? 12.079  18.875  1.029   1.00 21.36 ? 64  LEU C O   1 
ATOM   3724 C CB  . LEU C 3 64  ? 9.308   20.106  1.126   1.00 18.66 ? 64  LEU C CB  1 
ATOM   3725 C CG  . LEU C 3 64  ? 7.899   20.142  1.696   1.00 20.43 ? 64  LEU C CG  1 
ATOM   3726 C CD1 . LEU C 3 64  ? 7.700   21.512  2.245   1.00 14.45 ? 64  LEU C CD1 1 
ATOM   3727 C CD2 . LEU C 3 64  ? 6.924   19.825  0.533   1.00 16.49 ? 64  LEU C CD2 1 
ATOM   3728 N N   . ASN C 3 65  ? 11.460  18.813  -1.155  1.00 21.73 ? 65  ASN C N   1 
ATOM   3729 C CA  . ASN C 3 65  ? 12.813  18.993  -1.687  1.00 22.23 ? 65  ASN C CA  1 
ATOM   3730 C C   . ASN C 3 65  ? 13.737  17.868  -1.197  1.00 25.20 ? 65  ASN C C   1 
ATOM   3731 O O   . ASN C 3 65  ? 14.883  18.104  -0.839  1.00 24.67 ? 65  ASN C O   1 
ATOM   3732 C CB  . ASN C 3 65  ? 13.380  20.388  -1.321  1.00 21.68 ? 65  ASN C CB  1 
ATOM   3733 C CG  . ASN C 3 65  ? 12.609  21.564  -2.002  1.00 26.56 ? 65  ASN C CG  1 
ATOM   3734 O OD1 . ASN C 3 65  ? 11.630  21.329  -2.723  1.00 26.56 ? 65  ASN C OD1 1 
ATOM   3735 N ND2 . ASN C 3 65  ? 13.045  22.818  -1.759  1.00 24.27 ? 65  ASN C ND2 1 
ATOM   3736 N N   . GLY C 3 66  ? 13.228  16.635  -1.169  1.00 25.87 ? 66  GLY C N   1 
ATOM   3737 C CA  . GLY C 3 66  ? 13.990  15.466  -0.763  1.00 24.21 ? 66  GLY C CA  1 
ATOM   3738 C C   . GLY C 3 66  ? 14.399  14.613  -1.945  1.00 24.49 ? 66  GLY C C   1 
ATOM   3739 O O   . GLY C 3 66  ? 14.410  15.063  -3.095  1.00 22.68 ? 66  GLY C O   1 
ATOM   3740 N N   . SER C 3 67  ? 14.733  13.357  -1.676  1.00 20.37 ? 67  SER C N   1 
ATOM   3741 C CA  . SER C 3 67  ? 15.124  12.458  -2.761  1.00 22.81 ? 67  SER C CA  1 
ATOM   3742 C C   . SER C 3 67  ? 13.913  11.761  -3.380  1.00 23.24 ? 67  SER C C   1 
ATOM   3743 O O   . SER C 3 67  ? 12.972  11.381  -2.684  1.00 22.46 ? 67  SER C O   1 
ATOM   3744 C CB  . SER C 3 67  ? 16.127  11.413  -2.269  1.00 19.84 ? 67  SER C CB  1 
ATOM   3745 O OG  . SER C 3 67  ? 15.503  10.546  -1.326  1.00 23.87 ? 67  SER C OG  1 
ATOM   3746 N N   . LEU C 3 68  ? 13.949  11.589  -4.693  1.00 22.87 ? 68  LEU C N   1 
ATOM   3747 C CA  . LEU C 3 68  ? 12.955  10.815  -5.411  1.00 24.13 ? 68  LEU C CA  1 
ATOM   3748 C C   . LEU C 3 68  ? 13.488  9.423   -5.693  1.00 27.45 ? 68  LEU C C   1 
ATOM   3749 O O   . LEU C 3 68  ? 14.697  9.214   -5.812  1.00 25.15 ? 68  LEU C O   1 
ATOM   3750 C CB  . LEU C 3 68  ? 12.563  11.502  -6.727  1.00 23.78 ? 68  LEU C CB  1 
ATOM   3751 C CG  . LEU C 3 68  ? 11.943  12.894  -6.597  1.00 22.67 ? 68  LEU C CG  1 
ATOM   3752 C CD1 . LEU C 3 68  ? 12.076  13.720  -7.912  1.00 22.15 ? 68  LEU C CD1 1 
ATOM   3753 C CD2 . LEU C 3 68  ? 10.479  12.794  -6.132  1.00 22.16 ? 68  LEU C CD2 1 
ATOM   3754 N N   . ALA C 3 69  ? 12.573  8.469   -5.781  1.00 23.53 ? 69  ALA C N   1 
ATOM   3755 C CA  . ALA C 3 69  ? 12.900  7.157   -6.313  1.00 22.35 ? 69  ALA C CA  1 
ATOM   3756 C C   . ALA C 3 69  ? 13.051  7.219   -7.833  1.00 29.86 ? 69  ALA C C   1 
ATOM   3757 O O   . ALA C 3 69  ? 12.762  8.231   -8.487  1.00 31.95 ? 69  ALA C O   1 
ATOM   3758 C CB  . ALA C 3 69  ? 11.815  6.139   -5.935  1.00 25.92 ? 69  ALA C CB  1 
ATOM   3759 N N   . GLU C 3 70  ? 13.476  6.103   -8.407  1.00 31.66 ? 70  GLU C N   1 
ATOM   3760 C CA  . GLU C 3 70  ? 13.969  6.170   -9.772  1.00 41.18 ? 70  GLU C CA  1 
ATOM   3761 C C   . GLU C 3 70  ? 12.893  5.902   -10.810 1.00 42.36 ? 70  GLU C C   1 
ATOM   3762 O O   . GLU C 3 70  ? 12.822  6.618   -11.816 1.00 47.33 ? 70  GLU C O   1 
ATOM   3763 C CB  . GLU C 3 70  ? 15.139  5.201   -9.952  1.00 41.78 ? 70  GLU C CB  1 
ATOM   3764 C CG  . GLU C 3 70  ? 16.378  5.667   -9.208  1.00 49.72 ? 70  GLU C CG  1 
ATOM   3765 C CD  . GLU C 3 70  ? 17.667  5.432   -9.975  1.00 61.53 ? 70  GLU C CD  1 
ATOM   3766 O OE1 . GLU C 3 70  ? 18.089  4.261   -10.086 1.00 63.15 ? 70  GLU C OE1 1 
ATOM   3767 O OE2 . GLU C 3 70  ? 18.260  6.422   -10.465 1.00 64.57 ? 70  GLU C OE2 1 
ATOM   3768 N N   . GLU C 3 71  ? 12.045  4.922   -10.583 1.00 37.87 ? 71  GLU C N   1 
ATOM   3769 C CA  . GLU C 3 71  ? 11.088  4.535   -11.611 1.00 43.52 ? 71  GLU C CA  1 
ATOM   3770 C C   . GLU C 3 71  ? 9.645   4.495   -11.127 1.00 48.17 ? 71  GLU C C   1 
ATOM   3771 O O   . GLU C 3 71  ? 8.738   4.834   -11.891 1.00 51.06 ? 71  GLU C O   1 
ATOM   3772 C CB  . GLU C 3 71  ? 11.488  3.162   -12.184 1.00 51.06 ? 71  GLU C CB  1 
ATOM   3773 C CG  . GLU C 3 71  ? 11.875  3.211   -13.653 1.00 59.26 ? 71  GLU C CG  1 
ATOM   3774 C CD  . GLU C 3 71  ? 10.725  3.685   -14.537 1.00 69.78 ? 71  GLU C CD  1 
ATOM   3775 O OE1 . GLU C 3 71  ? 9.692   2.976   -14.610 1.00 67.86 ? 71  GLU C OE1 1 
ATOM   3776 O OE2 . GLU C 3 71  ? 10.846  4.774   -15.148 1.00 71.10 ? 71  GLU C OE2 1 
ATOM   3777 N N   . GLU C 3 72  ? 9.405   4.078   -9.888  1.00 39.75 ? 72  GLU C N   1 
ATOM   3778 C CA  . GLU C 3 72  ? 8.060   3.948   -9.351  1.00 35.42 ? 72  GLU C CA  1 
ATOM   3779 C C   . GLU C 3 72  ? 8.040   4.501   -7.936  1.00 28.53 ? 72  GLU C C   1 
ATOM   3780 O O   . GLU C 3 72  ? 9.081   4.731   -7.323  1.00 27.34 ? 72  GLU C O   1 
ATOM   3781 C CB  . GLU C 3 72  ? 7.592   2.485   -9.339  1.00 40.84 ? 72  GLU C CB  1 
ATOM   3782 C CG  . GLU C 3 72  ? 6.785   2.043   -10.549 1.00 49.06 ? 72  GLU C CG  1 
ATOM   3783 C CD  . GLU C 3 72  ? 6.442   0.551   -10.502 1.00 57.66 ? 72  GLU C CD  1 
ATOM   3784 O OE1 . GLU C 3 72  ? 6.870   -0.139  -9.541  1.00 59.67 ? 72  GLU C OE1 1 
ATOM   3785 O OE2 . GLU C 3 72  ? 5.754   0.064   -11.426 1.00 61.78 ? 72  GLU C OE2 1 
ATOM   3786 N N   . VAL C 3 73  ? 6.830   4.707   -7.414  1.00 32.20 ? 73  VAL C N   1 
ATOM   3787 C CA  . VAL C 3 73  ? 6.678   4.979   -5.993  1.00 31.00 ? 73  VAL C CA  1 
ATOM   3788 C C   . VAL C 3 73  ? 7.242   3.795   -5.205  1.00 25.94 ? 73  VAL C C   1 
ATOM   3789 O O   . VAL C 3 73  ? 7.056   2.632   -5.576  1.00 27.66 ? 73  VAL C O   1 
ATOM   3790 C CB  . VAL C 3 73  ? 5.196   5.237   -5.658  1.00 26.32 ? 73  VAL C CB  1 
ATOM   3791 C CG1 . VAL C 3 73  ? 4.972   5.231   -4.134  1.00 23.08 ? 73  VAL C CG1 1 
ATOM   3792 C CG2 . VAL C 3 73  ? 4.735   6.576   -6.261  1.00 29.13 ? 73  VAL C CG2 1 
ATOM   3793 N N   . VAL C 3 74  ? 7.952   4.085   -4.118  1.00 24.54 ? 74  VAL C N   1 
ATOM   3794 C CA  . VAL C 3 74  ? 8.492   3.051   -3.246  1.00 23.72 ? 74  VAL C CA  1 
ATOM   3795 C C   . VAL C 3 74  ? 7.986   3.315   -1.837  1.00 22.15 ? 74  VAL C C   1 
ATOM   3796 O O   . VAL C 3 74  ? 8.148   4.421   -1.315  1.00 24.01 ? 74  VAL C O   1 
ATOM   3797 C CB  . VAL C 3 74  ? 10.033  3.013   -3.260  1.00 25.41 ? 74  VAL C CB  1 
ATOM   3798 C CG1 . VAL C 3 74  ? 10.508  1.815   -2.433  1.00 24.93 ? 74  VAL C CG1 1 
ATOM   3799 C CG2 . VAL C 3 74  ? 10.586  2.924   -4.705  1.00 23.86 ? 74  VAL C CG2 1 
ATOM   3800 N N   . ILE C 3 75  ? 7.378   2.302   -1.224  1.00 21.82 ? 75  ILE C N   1 
ATOM   3801 C CA  . ILE C 3 75  ? 6.883   2.398   0.145   1.00 23.65 ? 75  ILE C CA  1 
ATOM   3802 C C   . ILE C 3 75  ? 7.728   1.496   1.024   1.00 24.73 ? 75  ILE C C   1 
ATOM   3803 O O   . ILE C 3 75  ? 8.036   0.355   0.651   1.00 23.38 ? 75  ILE C O   1 
ATOM   3804 C CB  . ILE C 3 75  ? 5.386   2.036   0.248   1.00 24.95 ? 75  ILE C CB  1 
ATOM   3805 C CG1 . ILE C 3 75  ? 5.131   0.604   -0.247  1.00 23.24 ? 75  ILE C CG1 1 
ATOM   3806 C CG2 . ILE C 3 75  ? 4.582   3.006   -0.574  1.00 21.30 ? 75  ILE C CG2 1 
ATOM   3807 C CD1 . ILE C 3 75  ? 3.777   0.065   0.164   1.00 25.35 ? 75  ILE C CD1 1 
ATOM   3808 N N   . ARG C 3 76  ? 8.114   2.016   2.184   1.00 21.57 ? 76  ARG C N   1 
ATOM   3809 C CA  . ARG C 3 76  ? 8.981   1.292   3.099   1.00 27.53 ? 76  ARG C CA  1 
ATOM   3810 C C   . ARG C 3 76  ? 8.453   1.422   4.519   1.00 24.46 ? 76  ARG C C   1 
ATOM   3811 O O   . ARG C 3 76  ? 7.888   2.455   4.900   1.00 22.35 ? 76  ARG C O   1 
ATOM   3812 C CB  . ARG C 3 76  ? 10.431  1.822   3.049   1.00 27.15 ? 76  ARG C CB  1 
ATOM   3813 C CG  . ARG C 3 76  ? 11.067  1.717   1.674   1.00 23.58 ? 76  ARG C CG  1 
ATOM   3814 C CD  . ARG C 3 76  ? 12.460  2.331   1.651   1.00 25.10 ? 76  ARG C CD  1 
ATOM   3815 N NE  . ARG C 3 76  ? 13.107  2.131   0.357   1.00 22.66 ? 76  ARG C NE  1 
ATOM   3816 C CZ  . ARG C 3 76  ? 13.221  3.077   -0.574  1.00 30.56 ? 76  ARG C CZ  1 
ATOM   3817 N NH1 . ARG C 3 76  ? 12.719  4.295   -0.400  1.00 24.11 ? 76  ARG C NH1 1 
ATOM   3818 N NH2 . ARG C 3 76  ? 13.859  2.797   -1.706  1.00 34.80 ? 76  ARG C NH2 1 
ATOM   3819 N N   . SER C 3 77  ? 8.684   0.372   5.307   1.00 21.83 ? 77  SER C N   1 
ATOM   3820 C CA  . SER C 3 77  ? 8.378   0.361   6.731   1.00 24.28 ? 77  SER C CA  1 
ATOM   3821 C C   . SER C 3 77  ? 9.332   -0.591  7.435   1.00 23.68 ? 77  SER C C   1 
ATOM   3822 O O   . SER C 3 77  ? 9.736   -1.617  6.875   1.00 27.15 ? 77  SER C O   1 
ATOM   3823 C CB  . SER C 3 77  ? 6.946   -0.095  7.038   1.00 21.81 ? 77  SER C CB  1 
ATOM   3824 O OG  . SER C 3 77  ? 6.834   -0.330  8.443   1.00 21.92 ? 77  SER C OG  1 
ATOM   3825 N N   . GLU C 3 78  ? 9.646   -0.272  8.685   1.00 25.85 ? 78  GLU C N   1 
ATOM   3826 C CA  . GLU C 3 78  ? 10.444  -1.194  9.482   1.00 25.99 ? 78  GLU C CA  1 
ATOM   3827 C C   . GLU C 3 78  ? 9.640   -2.401  9.959   1.00 25.21 ? 78  GLU C C   1 
ATOM   3828 O O   . GLU C 3 78  ? 10.231  -3.417  10.317  1.00 24.84 ? 78  GLU C O   1 
ATOM   3829 C CB  . GLU C 3 78  ? 11.064  -0.437  10.654  1.00 29.01 ? 78  GLU C CB  1 
ATOM   3830 C CG  . GLU C 3 78  ? 12.072  0.611   10.163  1.00 29.44 ? 78  GLU C CG  1 
ATOM   3831 C CD  . GLU C 3 78  ? 12.667  1.435   11.284  1.00 34.42 ? 78  GLU C CD  1 
ATOM   3832 O OE1 . GLU C 3 78  ? 12.997  0.850   12.341  1.00 33.30 ? 78  GLU C OE1 1 
ATOM   3833 O OE2 . GLU C 3 78  ? 12.785  2.670   11.109  1.00 29.77 ? 78  GLU C OE2 1 
ATOM   3834 N N   . ASP C 3 79  ? 8.314   -2.314  9.992   1.00 23.38 ? 79  ASP C N   1 
ATOM   3835 C CA  . ASP C 3 79  ? 7.480   -3.484  10.273  1.00 25.26 ? 79  ASP C CA  1 
ATOM   3836 C C   . ASP C 3 79  ? 6.084   -3.138  9.798   1.00 20.74 ? 79  ASP C C   1 
ATOM   3837 O O   . ASP C 3 79  ? 5.404   -2.349  10.455  1.00 23.80 ? 79  ASP C O   1 
ATOM   3838 C CB  . ASP C 3 79  ? 7.477   -3.831  11.771  1.00 22.89 ? 79  ASP C CB  1 
ATOM   3839 C CG  . ASP C 3 79  ? 6.667   -5.077  12.083  1.00 24.30 ? 79  ASP C CG  1 
ATOM   3840 O OD1 . ASP C 3 79  ? 6.117   -5.684  11.144  1.00 24.70 ? 79  ASP C OD1 1 
ATOM   3841 O OD2 . ASP C 3 79  ? 6.588   -5.464  13.269  1.00 24.50 ? 79  ASP C OD2 1 
ATOM   3842 N N   . TRP C 3 80  ? 5.654   -3.763  8.704   1.00 24.43 ? 80  TRP C N   1 
ATOM   3843 C CA  . TRP C 3 80  ? 4.353   -3.449  8.133   1.00 26.86 ? 80  TRP C CA  1 
ATOM   3844 C C   . TRP C 3 80  ? 3.225   -3.759  9.106   1.00 28.84 ? 80  TRP C C   1 
ATOM   3845 O O   . TRP C 3 80  ? 2.191   -3.083  9.092   1.00 23.24 ? 80  TRP C O   1 
ATOM   3846 C CB  . TRP C 3 80  ? 4.177   -4.215  6.827   1.00 26.39 ? 80  TRP C CB  1 
ATOM   3847 C CG  . TRP C 3 80  ? 5.157   -3.755  5.769   1.00 30.26 ? 80  TRP C CG  1 
ATOM   3848 C CD1 . TRP C 3 80  ? 6.290   -4.415  5.341   1.00 32.20 ? 80  TRP C CD1 1 
ATOM   3849 C CD2 . TRP C 3 80  ? 5.093   -2.534  5.011   1.00 28.44 ? 80  TRP C CD2 1 
ATOM   3850 N NE1 . TRP C 3 80  ? 6.937   -3.666  4.366   1.00 28.16 ? 80  TRP C NE1 1 
ATOM   3851 C CE2 . TRP C 3 80  ? 6.224   -2.510  4.152   1.00 29.71 ? 80  TRP C CE2 1 
ATOM   3852 C CE3 . TRP C 3 80  ? 4.194   -1.449  4.983   1.00 26.12 ? 80  TRP C CE3 1 
ATOM   3853 C CZ2 . TRP C 3 80  ? 6.463   -1.454  3.257   1.00 23.72 ? 80  TRP C CZ2 1 
ATOM   3854 C CZ3 . TRP C 3 80  ? 4.443   -0.399  4.110   1.00 27.68 ? 80  TRP C CZ3 1 
ATOM   3855 C CH2 . TRP C 3 80  ? 5.578   -0.407  3.258   1.00 28.54 ? 80  TRP C CH2 1 
ATOM   3856 N N   . ARG C 3 81  ? 3.407   -4.771  9.964   1.00 28.42 ? 81  ARG C N   1 
ATOM   3857 C CA  . ARG C 3 81  ? 2.352   -5.188  10.874  1.00 26.91 ? 81  ARG C CA  1 
ATOM   3858 C C   . ARG C 3 81  ? 2.232   -4.295  12.103  1.00 26.36 ? 81  ARG C C   1 
ATOM   3859 O O   . ARG C 3 81  ? 1.242   -4.398  12.820  1.00 27.45 ? 81  ARG C O   1 
ATOM   3860 C CB  . ARG C 3 81  ? 2.594   -6.636  11.298  1.00 29.80 ? 81  ARG C CB  1 
ATOM   3861 C CG  . ARG C 3 81  ? 2.731   -7.567  10.108  1.00 27.28 ? 81  ARG C CG  1 
ATOM   3862 C CD  . ARG C 3 81  ? 3.107   -8.969  10.535  1.00 33.27 ? 81  ARG C CD  1 
ATOM   3863 N NE  . ARG C 3 81  ? 4.445   -8.996  11.111  1.00 41.49 ? 81  ARG C NE  1 
ATOM   3864 C CZ  . ARG C 3 81  ? 5.506   -9.506  10.500  1.00 40.49 ? 81  ARG C CZ  1 
ATOM   3865 N NH1 . ARG C 3 81  ? 5.411   -10.062 9.302   1.00 44.47 ? 81  ARG C NH1 1 
ATOM   3866 N NH2 . ARG C 3 81  ? 6.689   -9.457  11.104  1.00 37.88 ? 81  ARG C NH2 1 
ATOM   3867 N N   . ASP C 3 82  ? 3.197   -3.422  12.360  1.00 24.27 ? 82  ASP C N   1 
ATOM   3868 C CA  . ASP C 3 82  ? 3.257   -2.640  13.595  1.00 27.84 ? 82  ASP C CA  1 
ATOM   3869 C C   . ASP C 3 82  ? 2.693   -1.243  13.347  1.00 24.66 ? 82  ASP C C   1 
ATOM   3870 O O   . ASP C 3 82  ? 3.351   -0.409  12.724  1.00 22.98 ? 82  ASP C O   1 
ATOM   3871 C CB  . ASP C 3 82  ? 4.705   -2.572  14.072  1.00 23.51 ? 82  ASP C CB  1 
ATOM   3872 C CG  . ASP C 3 82  ? 4.867   -1.882  15.418  1.00 27.02 ? 82  ASP C CG  1 
ATOM   3873 O OD1 . ASP C 3 82  ? 3.971   -1.136  15.879  1.00 24.51 ? 82  ASP C OD1 1 
ATOM   3874 O OD2 . ASP C 3 82  ? 5.939   -2.096  16.030  1.00 30.43 ? 82  ASP C OD2 1 
ATOM   3875 N N   . ASN C 3 83  ? 1.499   -0.969  13.873  1.00 25.32 ? 83  ASN C N   1 
ATOM   3876 C CA  . ASN C 3 83  ? 0.881   0.320   13.584  1.00 21.99 ? 83  ASN C CA  1 
ATOM   3877 C C   . ASN C 3 83  ? 1.586   1.474   14.285  1.00 25.74 ? 83  ASN C C   1 
ATOM   3878 O O   . ASN C 3 83  ? 1.255   2.635   14.016  1.00 22.82 ? 83  ASN C O   1 
ATOM   3879 C CB  . ASN C 3 83  ? -0.631  0.279   13.916  1.00 22.11 ? 83  ASN C CB  1 
ATOM   3880 C CG  . ASN C 3 83  ? -0.938  0.399   15.412  1.00 21.20 ? 83  ASN C CG  1 
ATOM   3881 O OD1 . ASN C 3 83  ? -0.366  1.235   16.126  1.00 21.48 ? 83  ASN C OD1 1 
ATOM   3882 N ND2 . ASN C 3 83  ? -1.898  -0.402  15.876  1.00 20.56 ? 83  ASN C ND2 1 
ATOM   3883 N N   . ALA C 3 84  ? 2.545   1.197   15.166  1.00 20.77 ? 84  ALA C N   1 
ATOM   3884 C CA  . ALA C 3 84  ? 3.341   2.264   15.748  1.00 25.45 ? 84  ALA C CA  1 
ATOM   3885 C C   . ALA C 3 84  ? 4.600   2.584   14.932  1.00 19.73 ? 84  ALA C C   1 
ATOM   3886 O O   . ALA C 3 84  ? 5.341   3.497   15.303  1.00 22.78 ? 84  ALA C O   1 
ATOM   3887 C CB  . ALA C 3 84  ? 3.710   1.921   17.204  1.00 25.82 ? 84  ALA C CB  1 
ATOM   3888 N N   . LYS C 3 85  ? 4.836   1.896   13.818  1.00 21.72 ? 85  LYS C N   1 
ATOM   3889 C CA  . LYS C 3 85  ? 5.896   2.263   12.877  1.00 25.43 ? 85  LYS C CA  1 
ATOM   3890 C C   . LYS C 3 85  ? 5.289   3.001   11.689  1.00 24.29 ? 85  LYS C C   1 
ATOM   3891 O O   . LYS C 3 85  ? 4.373   2.477   11.044  1.00 20.22 ? 85  LYS C O   1 
ATOM   3892 C CB  . LYS C 3 85  ? 6.627   1.035   12.340  1.00 22.21 ? 85  LYS C CB  1 
ATOM   3893 C CG  . LYS C 3 85  ? 7.043   0.038   13.387  1.00 32.76 ? 85  LYS C CG  1 
ATOM   3894 C CD  . LYS C 3 85  ? 8.335   0.467   13.976  1.00 24.53 ? 85  LYS C CD  1 
ATOM   3895 C CE  . LYS C 3 85  ? 8.958   -0.652  14.775  1.00 27.71 ? 85  LYS C CE  1 
ATOM   3896 N NZ  . LYS C 3 85  ? 9.794   -0.017  15.817  1.00 24.92 ? 85  LYS C NZ  1 
ATOM   3897 N N   . SER C 3 86  ? 5.842   4.172   11.355  1.00 23.20 ? 86  SER C N   1 
ATOM   3898 C CA  . SER C 3 86  ? 5.320   4.902   10.200  1.00 21.24 ? 86  SER C CA  1 
ATOM   3899 C C   . SER C 3 86  ? 5.693   4.187   8.899   1.00 22.83 ? 86  SER C C   1 
ATOM   3900 O O   . SER C 3 86  ? 6.549   3.291   8.868   1.00 21.53 ? 86  SER C O   1 
ATOM   3901 C CB  . SER C 3 86  ? 5.841   6.334   10.169  1.00 17.00 ? 86  SER C CB  1 
ATOM   3902 O OG  . SER C 3 86  ? 5.552   7.026   11.363  1.00 22.43 ? 86  SER C OG  1 
ATOM   3903 N N   . ILE C 3 87  ? 5.018   4.587   7.817   1.00 22.28 ? 87  ILE C N   1 
ATOM   3904 C CA  . ILE C 3 87  ? 5.267   4.083   6.471   1.00 18.28 ? 87  ILE C CA  1 
ATOM   3905 C C   . ILE C 3 87  ? 5.884   5.210   5.652   1.00 24.86 ? 87  ILE C C   1 
ATOM   3906 O O   . ILE C 3 87  ? 5.320   6.313   5.577   1.00 20.08 ? 87  ILE C O   1 
ATOM   3907 C CB  . ILE C 3 87  ? 3.976   3.571   5.818   1.00 24.54 ? 87  ILE C CB  1 
ATOM   3908 C CG1 . ILE C 3 87  ? 3.493   2.327   6.561   1.00 20.72 ? 87  ILE C CG1 1 
ATOM   3909 C CG2 . ILE C 3 87  ? 4.198   3.264   4.327   1.00 21.03 ? 87  ILE C CG2 1 
ATOM   3910 C CD1 . ILE C 3 87  ? 2.255   1.765   6.010   1.00 31.19 ? 87  ILE C CD1 1 
ATOM   3911 N N   . CYS C 3 88  ? 7.048   4.945   5.060   1.00 24.45 ? 88  CYS C N   1 
ATOM   3912 C CA  . CYS C 3 88  ? 7.815   5.968   4.349   1.00 19.86 ? 88  CYS C CA  1 
ATOM   3913 C C   . CYS C 3 88  ? 7.530   5.833   2.865   1.00 21.19 ? 88  CYS C C   1 
ATOM   3914 O O   . CYS C 3 88  ? 7.880   4.817   2.258   1.00 23.30 ? 88  CYS C O   1 
ATOM   3915 C CB  . CYS C 3 88  ? 9.312   5.805   4.601   1.00 21.94 ? 88  CYS C CB  1 
ATOM   3916 S SG  . CYS C 3 88  ? 9.833   5.949   6.350   1.00 24.47 ? 88  CYS C SG  1 
ATOM   3917 N N   . VAL C 3 89  ? 6.910   6.848   2.279   1.00 22.11 ? 89  VAL C N   1 
ATOM   3918 C CA  . VAL C 3 89  ? 6.550   6.811   0.867   1.00 20.71 ? 89  VAL C CA  1 
ATOM   3919 C C   . VAL C 3 89  ? 7.477   7.770   0.142   1.00 19.23 ? 89  VAL C C   1 
ATOM   3920 O O   . VAL C 3 89  ? 7.544   8.960   0.481   1.00 21.05 ? 89  VAL C O   1 
ATOM   3921 C CB  . VAL C 3 89  ? 5.080   7.192   0.634   1.00 23.30 ? 89  VAL C CB  1 
ATOM   3922 C CG1 . VAL C 3 89  ? 4.753   7.131   -0.849  1.00 18.73 ? 89  VAL C CG1 1 
ATOM   3923 C CG2 . VAL C 3 89  ? 4.122   6.274   1.458   1.00 24.42 ? 89  VAL C CG2 1 
ATOM   3924 N N   . GLN C 3 90  ? 8.202   7.256   -0.832  1.00 19.33 ? 90  GLN C N   1 
ATOM   3925 C CA  . GLN C 3 90  ? 9.077   8.081   -1.652  1.00 23.90 ? 90  GLN C CA  1 
ATOM   3926 C C   . GLN C 3 90  ? 8.489   8.129   -3.053  1.00 18.68 ? 90  GLN C C   1 
ATOM   3927 O O   . GLN C 3 90  ? 8.297   7.083   -3.678  1.00 23.11 ? 90  GLN C O   1 
ATOM   3928 C CB  . GLN C 3 90  ? 10.493  7.504   -1.678  1.00 22.08 ? 90  GLN C CB  1 
ATOM   3929 C CG  . GLN C 3 90  ? 11.484  8.265   -2.550  1.00 22.57 ? 90  GLN C CG  1 
ATOM   3930 C CD  . GLN C 3 90  ? 12.871  7.629   -2.505  1.00 21.74 ? 90  GLN C CD  1 
ATOM   3931 O OE1 . GLN C 3 90  ? 13.002  6.391   -2.551  1.00 24.76 ? 90  GLN C OE1 1 
ATOM   3932 N NE2 . GLN C 3 90  ? 13.917  8.469   -2.414  1.00 20.91 ? 90  GLN C NE2 1 
ATOM   3933 N N   . LEU C 3 91  ? 8.235   9.333   -3.545  1.00 21.81 ? 91  LEU C N   1 
ATOM   3934 C CA  . LEU C 3 91  ? 7.733   9.500   -4.903  1.00 25.31 ? 91  LEU C CA  1 
ATOM   3935 C C   . LEU C 3 91  ? 8.828   9.253   -5.939  1.00 29.58 ? 91  LEU C C   1 
ATOM   3936 O O   . LEU C 3 91  ? 10.024  9.393   -5.658  1.00 22.72 ? 91  LEU C O   1 
ATOM   3937 C CB  . LEU C 3 91  ? 7.176   10.906  -5.083  1.00 20.52 ? 91  LEU C CB  1 
ATOM   3938 C CG  . LEU C 3 91  ? 6.105   11.236  -4.049  1.00 22.52 ? 91  LEU C CG  1 
ATOM   3939 C CD1 . LEU C 3 91  ? 5.450   12.545  -4.378  1.00 20.87 ? 91  LEU C CD1 1 
ATOM   3940 C CD2 . LEU C 3 91  ? 5.073   10.107  -4.000  1.00 18.04 ? 91  LEU C CD2 1 
ATOM   3941 N N   . ALA C 3 92  ? 8.404   8.846   -7.148  1.00 26.20 ? 92  ALA C N   1 
ATOM   3942 C CA  . ALA C 3 92  ? 9.315   8.823   -8.289  1.00 29.83 ? 92  ALA C CA  1 
ATOM   3943 C C   . ALA C 3 92  ? 9.242   10.098  -9.122  1.00 32.94 ? 92  ALA C C   1 
ATOM   3944 O O   . ALA C 3 92  ? 10.230  10.452  -9.788  1.00 28.69 ? 92  ALA C O   1 
ATOM   3945 C CB  . ALA C 3 92  ? 9.034   7.604   -9.174  1.00 30.94 ? 92  ALA C CB  1 
ATOM   3946 N N   . THR C 3 93  ? 8.108   10.806  -9.098  1.00 26.25 ? 93  THR C N   1 
ATOM   3947 C CA  . THR C 3 93  ? 8.021   12.114  -9.724  1.00 29.63 ? 93  THR C CA  1 
ATOM   3948 C C   . THR C 3 93  ? 7.446   13.106  -8.720  1.00 25.44 ? 93  THR C C   1 
ATOM   3949 O O   . THR C 3 93  ? 6.425   12.834  -8.070  1.00 26.42 ? 93  THR C O   1 
ATOM   3950 C CB  . THR C 3 93  ? 7.185   12.095  -11.025 1.00 31.70 ? 93  THR C CB  1 
ATOM   3951 O OG1 . THR C 3 93  ? 5.837   12.442  -10.736 1.00 39.09 ? 93  THR C OG1 1 
ATOM   3952 C CG2 . THR C 3 93  ? 7.211   10.753  -11.718 1.00 21.93 ? 93  THR C CG2 1 
ATOM   3953 N N   . SER C 3 94  ? 8.112   14.244  -8.586  1.00 23.55 ? 94  SER C N   1 
ATOM   3954 C CA  . SER C 3 94  ? 7.746   15.205  -7.564  1.00 23.20 ? 94  SER C CA  1 
ATOM   3955 C C   . SER C 3 94  ? 6.415   15.881  -7.910  1.00 27.56 ? 94  SER C C   1 
ATOM   3956 O O   . SER C 3 94  ? 5.992   15.938  -9.070  1.00 22.82 ? 94  SER C O   1 
ATOM   3957 C CB  . SER C 3 94  ? 8.836   16.256  -7.402  1.00 23.75 ? 94  SER C CB  1 
ATOM   3958 O OG  . SER C 3 94  ? 9.064   16.937  -8.625  1.00 29.40 ? 94  SER C OG  1 
ATOM   3959 N N   . VAL C 3 95  ? 5.759   16.400  -6.878  1.00 25.44 ? 95  VAL C N   1 
ATOM   3960 C CA  . VAL C 3 95  ? 4.506   17.130  -7.019  1.00 23.30 ? 95  VAL C CA  1 
ATOM   3961 C C   . VAL C 3 95  ? 4.754   18.541  -6.541  1.00 23.17 ? 95  VAL C C   1 
ATOM   3962 O O   . VAL C 3 95  ? 5.058   18.760  -5.359  1.00 19.71 ? 95  VAL C O   1 
ATOM   3963 C CB  . VAL C 3 95  ? 3.360   16.473  -6.232  1.00 23.95 ? 95  VAL C CB  1 
ATOM   3964 C CG1 . VAL C 3 95  ? 2.078   17.290  -6.372  1.00 20.32 ? 95  VAL C CG1 1 
ATOM   3965 C CG2 . VAL C 3 95  ? 3.155   15.050  -6.726  1.00 26.20 ? 95  VAL C CG2 1 
ATOM   3966 N N   . GLU C 3 96  ? 4.615   19.502  -7.448  1.00 23.07 ? 96  GLU C N   1 
ATOM   3967 C CA  . GLU C 3 96  ? 4.919   20.876  -7.089  1.00 22.51 ? 96  GLU C CA  1 
ATOM   3968 C C   . GLU C 3 96  ? 3.867   21.423  -6.137  1.00 24.28 ? 96  GLU C C   1 
ATOM   3969 O O   . GLU C 3 96  ? 2.664   21.232  -6.345  1.00 28.68 ? 96  GLU C O   1 
ATOM   3970 C CB  . GLU C 3 96  ? 4.992   21.742  -8.343  1.00 27.07 ? 96  GLU C CB  1 
ATOM   3971 C CG  . GLU C 3 96  ? 5.266   23.217  -8.050  1.00 34.87 ? 96  GLU C CG  1 
ATOM   3972 C CD  . GLU C 3 96  ? 5.577   24.023  -9.317  1.00 41.10 ? 96  GLU C CD  1 
ATOM   3973 O OE1 . GLU C 3 96  ? 6.739   23.978  -9.793  1.00 37.77 ? 96  GLU C OE1 1 
ATOM   3974 O OE2 . GLU C 3 96  ? 4.653   24.687  -9.842  1.00 40.05 ? 96  GLU C OE2 1 
ATOM   3975 N N   . ILE C 3 97  ? 4.309   22.131  -5.101  1.00 22.88 ? 97  ILE C N   1 
ATOM   3976 C CA  . ILE C 3 97  ? 3.393   22.835  -4.214  1.00 22.59 ? 97  ILE C CA  1 
ATOM   3977 C C   . ILE C 3 97  ? 3.749   24.319  -4.273  1.00 25.60 ? 97  ILE C C   1 
ATOM   3978 O O   . ILE C 3 97  ? 4.819   24.735  -3.815  1.00 25.23 ? 97  ILE C O   1 
ATOM   3979 C CB  . ILE C 3 97  ? 3.412   22.261  -2.778  1.00 23.67 ? 97  ILE C CB  1 
ATOM   3980 C CG1 . ILE C 3 97  ? 2.549   23.096  -1.834  1.00 25.49 ? 97  ILE C CG1 1 
ATOM   3981 C CG2 . ILE C 3 97  ? 4.848   22.132  -2.221  1.00 24.86 ? 97  ILE C CG2 1 
ATOM   3982 C CD1 . ILE C 3 97  ? 2.132   22.348  -0.566  1.00 26.71 ? 97  ILE C CD1 1 
ATOM   3983 N N   . ALA C 3 98  ? 2.850   25.123  -4.850  1.00 24.63 ? 98  ALA C N   1 
ATOM   3984 C CA  . ALA C 3 98  ? 3.126   26.512  -5.197  1.00 19.84 ? 98  ALA C CA  1 
ATOM   3985 C C   . ALA C 3 98  ? 2.391   27.436  -4.240  1.00 26.74 ? 98  ALA C C   1 
ATOM   3986 O O   . ALA C 3 98  ? 1.154   27.402  -4.151  1.00 26.78 ? 98  ALA C O   1 
ATOM   3987 C CB  . ALA C 3 98  ? 2.715   26.791  -6.644  1.00 25.60 ? 98  ALA C CB  1 
ATOM   3988 N N   . CYS C 3 99  ? 3.139   28.274  -3.544  1.00 23.18 ? 99  CYS C N   1 
ATOM   3989 C CA  . CYS C 3 99  ? 2.574   29.150  -2.537  1.00 26.19 ? 99  CYS C CA  1 
ATOM   3990 C C   . CYS C 3 99  ? 2.372   30.538  -3.130  1.00 30.93 ? 99  CYS C C   1 
ATOM   3991 O O   . CYS C 3 99  ? 3.203   31.028  -3.900  1.00 30.08 ? 99  CYS C O   1 
ATOM   3992 C CB  . CYS C 3 99  ? 3.471   29.190  -1.294  1.00 25.97 ? 99  CYS C CB  1 
ATOM   3993 S SG  . CYS C 3 99  ? 3.579   27.555  -0.436  1.00 29.58 ? 99  CYS C SG  1 
ATOM   3994 N N   . THR C 3 100 ? 1.247   31.158  -2.783  1.00 29.05 ? 100 THR C N   1 
ATOM   3995 C CA  . THR C 3 100 ? 0.821   32.386  -3.428  1.00 26.95 ? 100 THR C CA  1 
ATOM   3996 C C   . THR C 3 100 ? 1.399   33.626  -2.775  1.00 28.91 ? 100 THR C C   1 
ATOM   3997 O O   . THR C 3 100 ? 1.446   34.680  -3.414  1.00 35.35 ? 100 THR C O   1 
ATOM   3998 C CB  . THR C 3 100 ? -0.714  32.505  -3.397  1.00 29.80 ? 100 THR C CB  1 
ATOM   3999 O OG1 . THR C 3 100 ? -1.137  32.755  -2.052  1.00 27.14 ? 100 THR C OG1 1 
ATOM   4000 C CG2 . THR C 3 100 ? -1.368  31.253  -3.884  1.00 27.54 ? 100 THR C CG2 1 
ATOM   4001 N N   . GLY C 3 101 ? 1.828   33.539  -1.526  1.00 26.60 ? 101 GLY C N   1 
ATOM   4002 C CA  . GLY C 3 101 ? 2.176   34.724  -0.780  1.00 27.59 ? 101 GLY C CA  1 
ATOM   4003 C C   . GLY C 3 101 ? 1.004   35.400  -0.110  1.00 28.76 ? 101 GLY C C   1 
ATOM   4004 O O   . GLY C 3 101 ? 1.206   36.385  0.608   1.00 31.22 ? 101 GLY C O   1 
ATOM   4005 N N   . ALA C 3 102 ? -0.213  34.888  -0.306  1.00 29.27 ? 102 ALA C N   1 
ATOM   4006 C CA  . ALA C 3 102 ? -1.436  35.480  0.227   1.00 33.18 ? 102 ALA C CA  1 
ATOM   4007 C C   . ALA C 3 102 ? -2.182  34.548  1.169   1.00 33.24 ? 102 ALA C C   1 
ATOM   4008 O O   . ALA C 3 102 ? -3.368  34.781  1.440   1.00 33.23 ? 102 ALA C O   1 
ATOM   4009 C CB  . ALA C 3 102 ? -2.385  35.882  -0.906  1.00 32.41 ? 102 ALA C CB  1 
ATOM   4010 N N   . GLY C 3 103 ? -1.541  33.484  1.639   1.00 32.85 ? 103 GLY C N   1 
ATOM   4011 C CA  . GLY C 3 103 ? -2.131  32.600  2.618   1.00 29.32 ? 103 GLY C CA  1 
ATOM   4012 C C   . GLY C 3 103 ? -2.482  31.225  2.115   1.00 28.55 ? 103 GLY C C   1 
ATOM   4013 O O   . GLY C 3 103 ? -3.049  30.444  2.883   1.00 35.63 ? 103 GLY C O   1 
ATOM   4014 N N   . HIS C 3 104 ? -2.181  30.886  0.867   1.00 25.39 ? 104 HIS C N   1 
ATOM   4015 C CA  . HIS C 3 104 ? -2.411  29.527  0.400   1.00 25.59 ? 104 HIS C CA  1 
ATOM   4016 C C   . HIS C 3 104 ? -1.187  28.988  -0.318  1.00 23.76 ? 104 HIS C C   1 
ATOM   4017 O O   . HIS C 3 104 ? -0.338  29.741  -0.788  1.00 29.18 ? 104 HIS C O   1 
ATOM   4018 C CB  . HIS C 3 104 ? -3.654  29.474  -0.497  1.00 27.37 ? 104 HIS C CB  1 
ATOM   4019 C CG  . HIS C 3 104 ? -4.770  30.279  0.070   1.00 26.02 ? 104 HIS C CG  1 
ATOM   4020 N ND1 . HIS C 3 104 ? -5.648  29.767  1.005   1.00 31.39 ? 104 HIS C ND1 1 
ATOM   4021 C CD2 . HIS C 3 104 ? -5.068  31.593  -0.052  1.00 27.17 ? 104 HIS C CD2 1 
ATOM   4022 C CE1 . HIS C 3 104 ? -6.474  30.722  1.394   1.00 29.31 ? 104 HIS C CE1 1 
ATOM   4023 N NE2 . HIS C 3 104 ? -6.144  31.840  0.765   1.00 37.36 ? 104 HIS C NE2 1 
ATOM   4024 N N   . CYS C 3 105 ? -1.109  27.661  -0.359  1.00 20.90 ? 105 CYS C N   1 
ATOM   4025 C CA  . CYS C 3 105 ? -0.205  26.917  -1.223  1.00 23.76 ? 105 CYS C CA  1 
ATOM   4026 C C   . CYS C 3 105 ? -1.021  25.900  -1.999  1.00 25.74 ? 105 CYS C C   1 
ATOM   4027 O O   . CYS C 3 105 ? -1.814  25.158  -1.410  1.00 27.48 ? 105 CYS C O   1 
ATOM   4028 C CB  . CYS C 3 105 ? 0.887   26.221  -0.401  1.00 19.37 ? 105 CYS C CB  1 
ATOM   4029 S SG  . CYS C 3 105 ? 1.797   27.392  0.613   1.00 27.68 ? 105 CYS C SG  1 
ATOM   4030 N N   . ALA C 3 106 ? -0.820  25.850  -3.303  1.00 24.12 ? 106 ALA C N   1 
ATOM   4031 C CA  . ALA C 3 106 ? -1.658  25.048  -4.170  1.00 22.92 ? 106 ALA C CA  1 
ATOM   4032 C C   . ALA C 3 106 ? -0.895  23.903  -4.811  1.00 26.08 ? 106 ALA C C   1 
ATOM   4033 O O   . ALA C 3 106 ? 0.282   24.027  -5.167  1.00 27.24 ? 106 ALA C O   1 
ATOM   4034 C CB  . ALA C 3 106 ? -2.276  25.906  -5.274  1.00 24.10 ? 106 ALA C CB  1 
ATOM   4035 N N   . ILE C 3 107 ? -1.622  22.809  -5.007  1.00 17.54 ? 107 ILE C N   1 
ATOM   4036 C CA  . ILE C 3 107 ? -1.155  21.585  -5.635  1.00 27.31 ? 107 ILE C CA  1 
ATOM   4037 C C   . ILE C 3 107 ? -2.115  21.244  -6.772  1.00 23.44 ? 107 ILE C C   1 
ATOM   4038 O O   . ILE C 3 107 ? -3.315  21.500  -6.682  1.00 25.99 ? 107 ILE C O   1 
ATOM   4039 C CB  . ILE C 3 107 ? -1.093  20.452  -4.580  1.00 24.81 ? 107 ILE C CB  1 
ATOM   4040 C CG1 . ILE C 3 107 ? 0.050   20.739  -3.595  1.00 28.33 ? 107 ILE C CG1 1 
ATOM   4041 C CG2 . ILE C 3 107 ? -0.975  19.071  -5.209  1.00 26.79 ? 107 ILE C CG2 1 
ATOM   4042 C CD1 . ILE C 3 107 ? -0.143  20.020  -2.225  1.00 33.19 ? 107 ILE C CD1 1 
ATOM   4043 N N   . SER C 3 108 ? -1.590  20.693  -7.855  1.00 22.83 ? 108 SER C N   1 
ATOM   4044 C CA  . SER C 3 108 ? -2.470  20.253  -8.926  1.00 25.54 ? 108 SER C CA  1 
ATOM   4045 C C   . SER C 3 108 ? -3.308  19.083  -8.433  1.00 28.12 ? 108 SER C C   1 
ATOM   4046 O O   . SER C 3 108 ? -2.766  18.085  -7.947  1.00 21.86 ? 108 SER C O   1 
ATOM   4047 C CB  . SER C 3 108 ? -1.656  19.841  -10.143 1.00 23.32 ? 108 SER C CB  1 
ATOM   4048 O OG  . SER C 3 108 ? -2.306  18.791  -10.830 1.00 25.18 ? 108 SER C OG  1 
ATOM   4049 N N   . ARG C 3 109 ? -4.634  19.202  -8.533  1.00 22.62 ? 109 ARG C N   1 
ATOM   4050 C CA  . ARG C 3 109 ? -5.470  18.125  -7.997  1.00 25.92 ? 109 ARG C CA  1 
ATOM   4051 C C   . ARG C 3 109 ? -5.250  16.837  -8.772  1.00 24.14 ? 109 ARG C C   1 
ATOM   4052 O O   . ARG C 3 109 ? -5.076  15.767  -8.179  1.00 24.19 ? 109 ARG C O   1 
ATOM   4053 C CB  . ARG C 3 109 ? -6.947  18.520  -8.020  1.00 24.42 ? 109 ARG C CB  1 
ATOM   4054 C CG  . ARG C 3 109 ? -7.830  17.608  -7.141  1.00 29.23 ? 109 ARG C CG  1 
ATOM   4055 C CD  . ARG C 3 109 ? -9.225  17.510  -7.717  1.00 28.27 ? 109 ARG C CD  1 
ATOM   4056 N NE  . ARG C 3 109 ? -9.160  16.970  -9.066  1.00 26.92 ? 109 ARG C NE  1 
ATOM   4057 C CZ  . ARG C 3 109 ? -9.071  15.673  -9.346  1.00 28.66 ? 109 ARG C CZ  1 
ATOM   4058 N NH1 . ARG C 3 109 ? -9.139  14.746  -8.391  1.00 18.20 ? 109 ARG C NH1 1 
ATOM   4059 N NH2 . ARG C 3 109 ? -8.920  15.293  -10.612 1.00 28.12 ? 109 ARG C NH2 1 
ATOM   4060 N N   . ALA C 3 110 ? -5.194  16.927  -10.100 1.00 18.63 ? 110 ALA C N   1 
ATOM   4061 C CA  . ALA C 3 110 ? -5.062  15.718  -10.896 1.00 22.26 ? 110 ALA C CA  1 
ATOM   4062 C C   . ALA C 3 110 ? -3.744  15.006  -10.600 1.00 27.19 ? 110 ALA C C   1 
ATOM   4063 O O   . ALA C 3 110 ? -3.685  13.766  -10.604 1.00 26.83 ? 110 ALA C O   1 
ATOM   4064 C CB  . ALA C 3 110 ? -5.158  16.055  -12.388 1.00 24.04 ? 110 ALA C CB  1 
ATOM   4065 N N   . LYS C 3 111 ? -2.664  15.773  -10.381 1.00 23.90 ? 111 LYS C N   1 
ATOM   4066 C CA  . LYS C 3 111 ? -1.374  15.148  -10.079 1.00 26.43 ? 111 LYS C CA  1 
ATOM   4067 C C   . LYS C 3 111 ? -1.385  14.499  -8.703  1.00 24.18 ? 111 LYS C C   1 
ATOM   4068 O O   . LYS C 3 111 ? -0.843  13.403  -8.528  1.00 25.71 ? 111 LYS C O   1 
ATOM   4069 C CB  . LYS C 3 111 ? -0.241  16.168  -10.162 1.00 27.62 ? 111 LYS C CB  1 
ATOM   4070 C CG  . LYS C 3 111 ? -0.017  16.719  -11.557 1.00 37.24 ? 111 LYS C CG  1 
ATOM   4071 C CD  . LYS C 3 111 ? 1.453   16.750  -11.935 1.00 43.07 ? 111 LYS C CD  1 
ATOM   4072 C CE  . LYS C 3 111 ? 1.679   17.719  -13.095 1.00 47.56 ? 111 LYS C CE  1 
ATOM   4073 N NZ  . LYS C 3 111 ? 0.526   17.679  -14.044 1.00 47.83 ? 111 LYS C NZ  1 
ATOM   4074 N N   . TRP C 3 112 ? -1.976  15.178  -7.713  1.00 25.74 ? 112 TRP C N   1 
ATOM   4075 C CA  . TRP C 3 112 ? -2.099  14.598  -6.381  1.00 25.37 ? 112 TRP C CA  1 
ATOM   4076 C C   . TRP C 3 112 ? -2.963  13.340  -6.402  1.00 25.79 ? 112 TRP C C   1 
ATOM   4077 O O   . TRP C 3 112 ? -2.592  12.305  -5.838  1.00 24.77 ? 112 TRP C O   1 
ATOM   4078 C CB  . TRP C 3 112 ? -2.675  15.625  -5.426  1.00 22.68 ? 112 TRP C CB  1 
ATOM   4079 C CG  . TRP C 3 112 ? -2.563  15.159  -4.036  1.00 27.66 ? 112 TRP C CG  1 
ATOM   4080 C CD1 . TRP C 3 112 ? -3.583  14.831  -3.182  1.00 28.39 ? 112 TRP C CD1 1 
ATOM   4081 C CD2 . TRP C 3 112 ? -1.342  14.905  -3.329  1.00 29.90 ? 112 TRP C CD2 1 
ATOM   4082 N NE1 . TRP C 3 112 ? -3.059  14.418  -1.971  1.00 28.27 ? 112 TRP C NE1 1 
ATOM   4083 C CE2 . TRP C 3 112 ? -1.691  14.452  -2.038  1.00 27.66 ? 112 TRP C CE2 1 
ATOM   4084 C CE3 . TRP C 3 112 ? 0.012   15.048  -3.651  1.00 25.25 ? 112 TRP C CE3 1 
ATOM   4085 C CZ2 . TRP C 3 112 ? -0.732  14.136  -1.074  1.00 24.57 ? 112 TRP C CZ2 1 
ATOM   4086 C CZ3 . TRP C 3 112 ? 0.957   14.720  -2.701  1.00 26.73 ? 112 TRP C CZ3 1 
ATOM   4087 C CH2 . TRP C 3 112 ? 0.579   14.276  -1.427  1.00 24.46 ? 112 TRP C CH2 1 
ATOM   4088 N N   . ALA C 3 113 ? -4.117  13.406  -7.077  1.00 24.84 ? 113 ALA C N   1 
ATOM   4089 C CA  . ALA C 3 113 ? -4.955  12.220  -7.216  1.00 22.03 ? 113 ALA C CA  1 
ATOM   4090 C C   . ALA C 3 113 ? -4.178  11.074  -7.839  1.00 23.63 ? 113 ALA C C   1 
ATOM   4091 O O   . ALA C 3 113 ? -4.284  9.919   -7.400  1.00 24.07 ? 113 ALA C O   1 
ATOM   4092 C CB  . ALA C 3 113 ? -6.194  12.542  -8.064  1.00 23.73 ? 113 ALA C CB  1 
ATOM   4093 N N   . ASN C 3 114 ? -3.397  11.361  -8.875  1.00 24.05 ? 114 ASN C N   1 
ATOM   4094 C CA  . ASN C 3 114 ? -2.701  10.258  -9.519  1.00 27.06 ? 114 ASN C CA  1 
ATOM   4095 C C   . ASN C 3 114 ? -1.550  9.737   -8.657  1.00 27.66 ? 114 ASN C C   1 
ATOM   4096 O O   . ASN C 3 114 ? -1.228  8.543   -8.702  1.00 28.01 ? 114 ASN C O   1 
ATOM   4097 C CB  . ASN C 3 114 ? -2.200  10.669  -10.899 1.00 30.67 ? 114 ASN C CB  1 
ATOM   4098 C CG  . ASN C 3 114 ? -1.671  9.483   -11.675 1.00 37.97 ? 114 ASN C CG  1 
ATOM   4099 O OD1 . ASN C 3 114 ? -0.463  9.315   -11.825 1.00 42.37 ? 114 ASN C OD1 1 
ATOM   4100 N ND2 . ASN C 3 114 ? -2.576  8.617   -12.121 1.00 42.19 ? 114 ASN C ND2 1 
ATOM   4101 N N   . THR C 3 115 ? -0.933  10.606  -7.866  1.00 23.96 ? 115 THR C N   1 
ATOM   4102 C CA  . THR C 3 115 ? 0.063   10.141  -6.906  1.00 26.12 ? 115 THR C CA  1 
ATOM   4103 C C   . THR C 3 115 ? -0.577  9.218   -5.867  1.00 26.66 ? 115 THR C C   1 
ATOM   4104 O O   . THR C 3 115 ? -0.131  8.078   -5.678  1.00 23.53 ? 115 THR C O   1 
ATOM   4105 C CB  . THR C 3 115 ? 0.739   11.353  -6.261  1.00 23.43 ? 115 THR C CB  1 
ATOM   4106 O OG1 . THR C 3 115 ? 1.345   12.148  -7.287  1.00 23.26 ? 115 THR C OG1 1 
ATOM   4107 C CG2 . THR C 3 115 ? 1.799   10.947  -5.247  1.00 23.94 ? 115 THR C CG2 1 
ATOM   4108 N N   . LEU C 3 116 ? -1.685  9.659   -5.247  1.00 23.63 ? 116 LEU C N   1 
ATOM   4109 C CA  . LEU C 3 116 ? -2.343  8.807   -4.253  1.00 22.81 ? 116 LEU C CA  1 
ATOM   4110 C C   . LEU C 3 116 ? -2.734  7.474   -4.868  1.00 25.64 ? 116 LEU C C   1 
ATOM   4111 O O   . LEU C 3 116 ? -2.517  6.411   -4.270  1.00 23.65 ? 116 LEU C O   1 
ATOM   4112 C CB  . LEU C 3 116 ? -3.571  9.512   -3.668  1.00 24.98 ? 116 LEU C CB  1 
ATOM   4113 C CG  . LEU C 3 116 ? -3.353  10.762  -2.819  1.00 24.34 ? 116 LEU C CG  1 
ATOM   4114 C CD1 . LEU C 3 116 ? -4.684  11.321  -2.319  1.00 20.68 ? 116 LEU C CD1 1 
ATOM   4115 C CD2 . LEU C 3 116 ? -2.432  10.474  -1.636  1.00 24.76 ? 116 LEU C CD2 1 
ATOM   4116 N N   . LYS C 3 117 ? -3.271  7.507   -6.085  1.00 25.34 ? 117 LYS C N   1 
ATOM   4117 C CA  . LYS C 3 117 ? -3.611  6.272   -6.766  1.00 25.31 ? 117 LYS C CA  1 
ATOM   4118 C C   . LYS C 3 117 ? -2.419  5.326   -6.813  1.00 27.07 ? 117 LYS C C   1 
ATOM   4119 O O   . LYS C 3 117 ? -2.558  4.128   -6.539  1.00 24.72 ? 117 LYS C O   1 
ATOM   4120 C CB  . LYS C 3 117 ? -4.125  6.581   -8.171  1.00 26.45 ? 117 LYS C CB  1 
ATOM   4121 C CG  . LYS C 3 117 ? -4.401  5.333   -8.981  1.00 31.45 ? 117 LYS C CG  1 
ATOM   4122 C CD  . LYS C 3 117 ? -5.185  5.672   -10.250 1.00 38.74 ? 117 LYS C CD  1 
ATOM   4123 C CE  . LYS C 3 117 ? -4.753  4.790   -11.419 1.00 46.79 ? 117 LYS C CE  1 
ATOM   4124 N NZ  . LYS C 3 117 ? -5.644  4.928   -12.620 1.00 62.95 ? 117 LYS C NZ  1 
ATOM   4125 N N   . GLN C 3 118 ? -1.229  5.854   -7.117  1.00 24.53 ? 118 GLN C N   1 
ATOM   4126 C CA  . GLN C 3 118 ? -0.038  5.008   -7.140  1.00 28.30 ? 118 GLN C CA  1 
ATOM   4127 C C   . GLN C 3 118 ? 0.341   4.530   -5.738  1.00 26.37 ? 118 GLN C C   1 
ATOM   4128 O O   . GLN C 3 118 ? 0.656   3.347   -5.552  1.00 30.45 ? 118 GLN C O   1 
ATOM   4129 C CB  . GLN C 3 118 ? 1.123   5.755   -7.795  1.00 28.16 ? 118 GLN C CB  1 
ATOM   4130 C CG  . GLN C 3 118 ? 0.959   5.971   -9.297  1.00 33.26 ? 118 GLN C CG  1 
ATOM   4131 C CD  . GLN C 3 118 ? 2.078   6.812   -9.889  1.00 34.74 ? 118 GLN C CD  1 
ATOM   4132 O OE1 . GLN C 3 118 ? 3.204   6.331   -10.062 1.00 39.88 ? 118 GLN C OE1 1 
ATOM   4133 N NE2 . GLN C 3 118 ? 1.776   8.077   -10.200 1.00 32.28 ? 118 GLN C NE2 1 
ATOM   4134 N N   . ILE C 3 119 ? 0.301   5.423   -4.744  1.00 23.53 ? 119 ILE C N   1 
ATOM   4135 C CA  . ILE C 3 119 ? 0.559   5.017   -3.363  1.00 23.06 ? 119 ILE C CA  1 
ATOM   4136 C C   . ILE C 3 119 ? -0.430  3.933   -2.925  1.00 29.82 ? 119 ILE C C   1 
ATOM   4137 O O   . ILE C 3 119 ? -0.041  2.913   -2.340  1.00 26.34 ? 119 ILE C O   1 
ATOM   4138 C CB  . ILE C 3 119 ? 0.530   6.247   -2.433  1.00 29.08 ? 119 ILE C CB  1 
ATOM   4139 C CG1 . ILE C 3 119 ? 1.564   7.291   -2.899  1.00 20.92 ? 119 ILE C CG1 1 
ATOM   4140 C CG2 . ILE C 3 119 ? 0.769   5.826   -0.971  1.00 24.55 ? 119 ILE C CG2 1 
ATOM   4141 C CD1 . ILE C 3 119 ? 1.586   8.626   -2.118  1.00 17.83 ? 119 ILE C CD1 1 
ATOM   4142 N N   . ALA C 3 120 ? -1.717  4.118   -3.240  1.00 27.58 ? 120 ALA C N   1 
ATOM   4143 C CA  . ALA C 3 120 ? -2.725  3.115   -2.915  1.00 25.83 ? 120 ALA C CA  1 
ATOM   4144 C C   . ALA C 3 120 ? -2.392  1.788   -3.573  1.00 29.10 ? 120 ALA C C   1 
ATOM   4145 O O   . ALA C 3 120 ? -2.546  0.721   -2.964  1.00 28.52 ? 120 ALA C O   1 
ATOM   4146 C CB  . ALA C 3 120 ? -4.127  3.593   -3.350  1.00 22.47 ? 120 ALA C CB  1 
ATOM   4147 N N   . SER C 3 121 ? -1.932  1.835   -4.819  1.00 26.14 ? 121 SER C N   1 
ATOM   4148 C CA  . SER C 3 121 ? -1.581  0.609   -5.513  1.00 27.49 ? 121 SER C CA  1 
ATOM   4149 C C   . SER C 3 121 ? -0.469  -0.139  -4.781  1.00 28.19 ? 121 SER C C   1 
ATOM   4150 O O   . SER C 3 121 ? -0.550  -1.357  -4.586  1.00 31.15 ? 121 SER C O   1 
ATOM   4151 C CB  . SER C 3 121 ? -1.172  0.942   -6.946  1.00 29.10 ? 121 SER C CB  1 
ATOM   4152 O OG  . SER C 3 121 ? -0.924  -0.242  -7.666  1.00 30.95 ? 121 SER C OG  1 
ATOM   4153 N N   . LYS C 3 122 ? 0.580   0.574   -4.359  1.00 26.78 ? 122 LYS C N   1 
ATOM   4154 C CA  . LYS C 3 122 ? 1.669   -0.098  -3.644  1.00 31.09 ? 122 LYS C CA  1 
ATOM   4155 C C   . LYS C 3 122 ? 1.212   -0.583  -2.264  1.00 33.90 ? 122 LYS C C   1 
ATOM   4156 O O   . LYS C 3 122 ? 1.584   -1.679  -1.835  1.00 34.09 ? 122 LYS C O   1 
ATOM   4157 C CB  . LYS C 3 122 ? 2.890   0.827   -3.520  1.00 27.52 ? 122 LYS C CB  1 
ATOM   4158 C CG  . LYS C 3 122 ? 3.573   1.226   -4.835  1.00 26.33 ? 122 LYS C CG  1 
ATOM   4159 C CD  . LYS C 3 122 ? 4.126   0.029   -5.582  1.00 31.73 ? 122 LYS C CD  1 
ATOM   4160 C CE  . LYS C 3 122 ? 4.647   0.417   -6.967  1.00 35.04 ? 122 LYS C CE  1 
ATOM   4161 N NZ  . LYS C 3 122 ? 5.280   -0.751  -7.650  1.00 41.27 ? 122 LYS C NZ  1 
ATOM   4162 N N   . LEU C 3 123 ? 0.403   0.210   -1.549  1.00 30.46 ? 123 LEU C N   1 
ATOM   4163 C CA  . LEU C 3 123 ? -0.091  -0.241  -0.245  1.00 26.31 ? 123 LEU C CA  1 
ATOM   4164 C C   . LEU C 3 123 ? -0.940  -1.491  -0.390  1.00 33.47 ? 123 LEU C C   1 
ATOM   4165 O O   . LEU C 3 123 ? -0.813  -2.447  0.388   1.00 31.01 ? 123 LEU C O   1 
ATOM   4166 C CB  . LEU C 3 123 ? -0.904  0.863   0.419   1.00 23.85 ? 123 LEU C CB  1 
ATOM   4167 C CG  . LEU C 3 123 ? 0.007   1.997   0.865   1.00 28.75 ? 123 LEU C CG  1 
ATOM   4168 C CD1 . LEU C 3 123 ? -0.758  3.260   1.210   1.00 23.59 ? 123 LEU C CD1 1 
ATOM   4169 C CD2 . LEU C 3 123 ? 0.842   1.498   2.044   1.00 28.39 ? 123 LEU C CD2 1 
ATOM   4170 N N   . ARG C 3 124 ? -1.812  -1.493  -1.394  1.00 31.11 ? 124 ARG C N   1 
ATOM   4171 C CA  . ARG C 3 124 ? -2.697  -2.619  -1.623  1.00 34.73 ? 124 ARG C CA  1 
ATOM   4172 C C   . ARG C 3 124 ? -1.897  -3.895  -1.843  1.00 38.04 ? 124 ARG C C   1 
ATOM   4173 O O   . ARG C 3 124 ? -2.250  -4.963  -1.318  1.00 34.50 ? 124 ARG C O   1 
ATOM   4174 C CB  . ARG C 3 124 ? -3.592  -2.276  -2.816  1.00 34.76 ? 124 ARG C CB  1 
ATOM   4175 C CG  . ARG C 3 124 ? -4.554  -3.338  -3.257  1.00 43.80 ? 124 ARG C CG  1 
ATOM   4176 C CD  . ARG C 3 124 ? -5.347  -2.856  -4.460  1.00 37.20 ? 124 ARG C CD  1 
ATOM   4177 N NE  . ARG C 3 124 ? -6.113  -1.658  -4.141  1.00 37.31 ? 124 ARG C NE  1 
ATOM   4178 C CZ  . ARG C 3 124 ? -5.909  -0.466  -4.687  1.00 40.21 ? 124 ARG C CZ  1 
ATOM   4179 N NH1 . ARG C 3 124 ? -4.941  -0.261  -5.575  1.00 33.59 ? 124 ARG C NH1 1 
ATOM   4180 N NH2 . ARG C 3 124 ? -6.707  0.545   -4.352  1.00 36.60 ? 124 ARG C NH2 1 
ATOM   4181 N N   . GLU C 3 125 ? -0.783  -3.791  -2.582  1.00 35.18 ? 125 GLU C N   1 
ATOM   4182 C CA  . GLU C 3 125 ? 0.065   -4.951  -2.824  1.00 38.11 ? 125 GLU C CA  1 
ATOM   4183 C C   . GLU C 3 125 ? 0.835   -5.341  -1.573  1.00 38.18 ? 125 GLU C C   1 
ATOM   4184 O O   . GLU C 3 125 ? 1.148   -6.517  -1.381  1.00 44.48 ? 125 GLU C O   1 
ATOM   4185 C CB  . GLU C 3 125 ? 1.028   -4.681  -3.991  1.00 41.55 ? 125 GLU C CB  1 
ATOM   4186 C CG  . GLU C 3 125 ? 2.420   -4.159  -3.595  1.00 47.24 ? 125 GLU C CG  1 
ATOM   4187 C CD  . GLU C 3 125 ? 3.309   -3.795  -4.799  1.00 54.54 ? 125 GLU C CD  1 
ATOM   4188 O OE1 . GLU C 3 125 ? 4.555   -3.915  -4.685  1.00 55.42 ? 125 GLU C OE1 1 
ATOM   4189 O OE2 . GLU C 3 125 ? 2.764   -3.383  -5.854  1.00 54.94 ? 125 GLU C OE2 1 
ATOM   4190 N N   . GLN C 3 126 ? 1.144   -4.382  -0.709  1.00 34.17 ? 126 GLN C N   1 
ATOM   4191 C CA  . GLN C 3 126 ? 1.799   -4.722  0.545   1.00 32.42 ? 126 GLN C CA  1 
ATOM   4192 C C   . GLN C 3 126 ? 0.834   -5.418  1.497   1.00 36.76 ? 126 GLN C C   1 
ATOM   4193 O O   . GLN C 3 126 ? 1.163   -6.454  2.080   1.00 36.36 ? 126 GLN C O   1 
ATOM   4194 C CB  . GLN C 3 126 ? 2.374   -3.462  1.187   1.00 34.69 ? 126 GLN C CB  1 
ATOM   4195 C CG  . GLN C 3 126 ? 3.326   -3.737  2.311   1.00 32.14 ? 126 GLN C CG  1 
ATOM   4196 C CD  . GLN C 3 126 ? 4.426   -4.709  1.909   1.00 34.92 ? 126 GLN C CD  1 
ATOM   4197 O OE1 . GLN C 3 126 ? 5.096   -4.533  0.887   1.00 35.74 ? 126 GLN C OE1 1 
ATOM   4198 N NE2 . GLN C 3 126 ? 4.607   -5.745  2.708   1.00 29.66 ? 126 GLN C NE2 1 
ATOM   4199 N N   . TYR C 3 127 ? -0.374  -4.871  1.655   1.00 35.88 ? 127 TYR C N   1 
ATOM   4200 C CA  . TYR C 3 127 ? -1.304  -5.328  2.680   1.00 33.88 ? 127 TYR C CA  1 
ATOM   4201 C C   . TYR C 3 127 ? -2.359  -6.286  2.154   1.00 38.63 ? 127 TYR C C   1 
ATOM   4202 O O   . TYR C 3 127 ? -3.226  -6.718  2.925   1.00 35.80 ? 127 TYR C O   1 
ATOM   4203 C CB  . TYR C 3 127 ? -1.983  -4.125  3.348   1.00 30.61 ? 127 TYR C CB  1 
ATOM   4204 C CG  . TYR C 3 127 ? -1.077  -3.393  4.307   1.00 25.40 ? 127 TYR C CG  1 
ATOM   4205 C CD1 . TYR C 3 127 ? -0.868  -3.876  5.587   1.00 23.63 ? 127 TYR C CD1 1 
ATOM   4206 C CD2 . TYR C 3 127 ? -0.404  -2.237  3.919   1.00 25.04 ? 127 TYR C CD2 1 
ATOM   4207 C CE1 . TYR C 3 127 ? -0.032  -3.222  6.465   1.00 22.91 ? 127 TYR C CE1 1 
ATOM   4208 C CE2 . TYR C 3 127 ? 0.425   -1.583  4.777   1.00 22.94 ? 127 TYR C CE2 1 
ATOM   4209 C CZ  . TYR C 3 127 ? 0.606   -2.079  6.060   1.00 24.79 ? 127 TYR C CZ  1 
ATOM   4210 O OH  . TYR C 3 127 ? 1.430   -1.427  6.932   1.00 25.08 ? 127 TYR C OH  1 
ATOM   4211 N N   . GLY C 3 128 ? -2.309  -6.628  0.872   1.00 36.74 ? 128 GLY C N   1 
ATOM   4212 C CA  . GLY C 3 128 ? -3.228  -7.619  0.342   1.00 33.48 ? 128 GLY C CA  1 
ATOM   4213 C C   . GLY C 3 128 ? -4.666  -7.204  0.525   1.00 44.85 ? 128 GLY C C   1 
ATOM   4214 O O   . GLY C 3 128 ? -5.524  -8.036  0.854   1.00 41.12 ? 128 GLY C O   1 
ATOM   4215 N N   . ALA C 3 129 ? -4.945  -5.931  0.339   1.00 36.37 ? 129 ALA C N   1 
ATOM   4216 C CA  . ALA C 3 129 ? -6.265  -5.411  0.569   1.00 44.02 ? 129 ALA C CA  1 
ATOM   4217 C C   . ALA C 3 129 ? -6.887  -5.081  -0.779  1.00 45.79 ? 129 ALA C C   1 
ATOM   4218 O O   . ALA C 3 129 ? -6.338  -5.386  -1.848  1.00 44.82 ? 129 ALA C O   1 
ATOM   4219 C CB  . ALA C 3 129 ? -6.205  -4.196  1.499   1.00 39.91 ? 129 ALA C CB  1 
ATOM   4220 N N   . LYS C 3 130 ? -8.062  -4.493  -0.726  1.00 37.20 ? 130 LYS C N   1 
ATOM   4221 C CA  . LYS C 3 130 ? -8.684  -3.956  -1.916  1.00 43.63 ? 130 LYS C CA  1 
ATOM   4222 C C   . LYS C 3 130 ? -8.824  -2.454  -1.807  1.00 39.74 ? 130 LYS C C   1 
ATOM   4223 O O   . LYS C 3 130 ? -8.371  -1.726  -2.692  1.00 42.57 ? 130 LYS C O   1 
ATOM   4224 C CB  . LYS C 3 130 ? -10.054 -4.618  -2.140  1.00 48.32 ? 130 LYS C CB  1 
ATOM   4225 C CG  . LYS C 3 130 ? -9.980  -6.124  -2.385  1.00 48.71 ? 130 LYS C CG  1 
ATOM   4226 C CD  . LYS C 3 130 ? -11.382 -6.749  -2.455  1.00 61.63 ? 130 LYS C CD  1 
ATOM   4227 C CE  . LYS C 3 130 ? -12.408 -5.849  -3.165  1.00 56.24 ? 130 LYS C CE  1 
ATOM   4228 N NZ  . LYS C 3 130 ? -13.200 -6.575  -4.201  1.00 59.62 ? 130 LYS C NZ  1 
ATOM   4229 N N   . THR C 3 131 ? -9.384  -1.970  -0.713  1.00 31.77 ? 131 THR C N   1 
ATOM   4230 C CA  . THR C 3 131 ? -9.735  -0.573  -0.582  1.00 30.22 ? 131 THR C CA  1 
ATOM   4231 C C   . THR C 3 131 ? -8.765  0.133   0.354   1.00 28.90 ? 131 THR C C   1 
ATOM   4232 O O   . THR C 3 131 ? -8.578  -0.279  1.503   1.00 30.88 ? 131 THR C O   1 
ATOM   4233 C CB  . THR C 3 131 ? -11.171 -0.447  -0.085  1.00 33.71 ? 131 THR C CB  1 
ATOM   4234 O OG1 . THR C 3 131 ? -12.030 -1.011  -1.079  1.00 34.14 ? 131 THR C OG1 1 
ATOM   4235 C CG2 . THR C 3 131 ? -11.533 1.008   0.160   1.00 29.25 ? 131 THR C CG2 1 
ATOM   4236 N N   . ILE C 3 132 ? -8.176  1.211   -0.140  1.00 26.23 ? 132 ILE C N   1 
ATOM   4237 C CA  . ILE C 3 132 ? -7.233  2.031   0.608   1.00 22.92 ? 132 ILE C CA  1 
ATOM   4238 C C   . ILE C 3 132 ? -7.882  3.382   0.832   1.00 24.23 ? 132 ILE C C   1 
ATOM   4239 O O   . ILE C 3 132 ? -8.311  4.040   -0.124  1.00 24.45 ? 132 ILE C O   1 
ATOM   4240 C CB  . ILE C 3 132 ? -5.910  2.200   -0.152  1.00 26.11 ? 132 ILE C CB  1 
ATOM   4241 C CG1 . ILE C 3 132 ? -5.347  0.831   -0.592  1.00 27.67 ? 132 ILE C CG1 1 
ATOM   4242 C CG2 . ILE C 3 132 ? -4.952  3.073   0.675   1.00 23.60 ? 132 ILE C CG2 1 
ATOM   4243 C CD1 . ILE C 3 132 ? -4.922  -0.066  0.543   1.00 28.84 ? 132 ILE C CD1 1 
ATOM   4244 N N   . ILE C 3 133 ? -7.941  3.806   2.078   1.00 22.79 ? 133 ILE C N   1 
ATOM   4245 C CA  . ILE C 3 133 ? -8.569  5.066   2.431   1.00 22.04 ? 133 ILE C CA  1 
ATOM   4246 C C   . ILE C 3 133 ? -7.528  5.940   3.105   1.00 22.84 ? 133 ILE C C   1 
ATOM   4247 O O   . ILE C 3 133 ? -6.924  5.529   4.100   1.00 20.80 ? 133 ILE C O   1 
ATOM   4248 C CB  . ILE C 3 133 ? -9.768  4.864   3.379   1.00 21.79 ? 133 ILE C CB  1 
ATOM   4249 C CG1 . ILE C 3 133 ? -10.795 3.878   2.796   1.00 23.66 ? 133 ILE C CG1 1 
ATOM   4250 C CG2 . ILE C 3 133 ? -10.358 6.240   3.774   1.00 20.65 ? 133 ILE C CG2 1 
ATOM   4251 C CD1 . ILE C 3 133 ? -12.087 3.764   3.642   1.00 25.93 ? 133 ILE C CD1 1 
ATOM   4252 N N   . PHE C 3 134 ? -7.372  7.160   2.612   1.00 16.00 ? 134 PHE C N   1 
ATOM   4253 C CA  . PHE C 3 134 ? -6.583  8.170   3.295   1.00 22.06 ? 134 PHE C CA  1 
ATOM   4254 C C   . PHE C 3 134 ? -7.530  9.058   4.071   1.00 21.63 ? 134 PHE C C   1 
ATOM   4255 O O   . PHE C 3 134 ? -8.540  9.526   3.511   1.00 21.63 ? 134 PHE C O   1 
ATOM   4256 C CB  . PHE C 3 134 ? -5.755  9.017   2.310   1.00 20.24 ? 134 PHE C CB  1 
ATOM   4257 C CG  . PHE C 3 134 ? -4.824  8.204   1.446   1.00 24.26 ? 134 PHE C CG  1 
ATOM   4258 C CD1 . PHE C 3 134 ? -3.590  7.771   1.935   1.00 23.60 ? 134 PHE C CD1 1 
ATOM   4259 C CD2 . PHE C 3 134 ? -5.178  7.873   0.147   1.00 22.72 ? 134 PHE C CD2 1 
ATOM   4260 C CE1 . PHE C 3 134 ? -2.740  7.022   1.139   1.00 25.51 ? 134 PHE C CE1 1 
ATOM   4261 C CE2 . PHE C 3 134 ? -4.335  7.115   -0.654  1.00 23.05 ? 134 PHE C CE2 1 
ATOM   4262 C CZ  . PHE C 3 134 ? -3.114  6.691   -0.154  1.00 29.31 ? 134 PHE C CZ  1 
ATOM   4263 N N   . LYS C 3 135 ? -7.203  9.300   5.337   1.00 19.97 ? 135 LYS C N   1 
ATOM   4264 C CA  . LYS C 3 135 ? -7.970  10.184  6.207   1.00 21.60 ? 135 LYS C CA  1 
ATOM   4265 C C   . LYS C 3 135 ? -7.040  11.201  6.831   1.00 19.72 ? 135 LYS C C   1 
ATOM   4266 O O   . LYS C 3 135 ? -5.819  11.021  6.814   1.00 23.61 ? 135 LYS C O   1 
ATOM   4267 C CB  . LYS C 3 135 ? -8.694  9.404   7.310   1.00 21.02 ? 135 LYS C CB  1 
ATOM   4268 C CG  . LYS C 3 135 ? -9.595  8.291   6.804   1.00 22.79 ? 135 LYS C CG  1 
ATOM   4269 C CD  . LYS C 3 135 ? -10.517 7.818   7.934   1.00 21.23 ? 135 LYS C CD  1 
ATOM   4270 C CE  . LYS C 3 135 ? -11.448 6.723   7.429   1.00 30.64 ? 135 LYS C CE  1 
ATOM   4271 N NZ  . LYS C 3 135 ? -12.376 6.242   8.481   1.00 30.02 ? 135 LYS C NZ  1 
ATOM   4272 N N   . PRO C 3 136 ? -7.574  12.298  7.374   1.00 18.11 ? 136 PRO C N   1 
ATOM   4273 C CA  . PRO C 3 136 ? -6.716  13.362  7.897   1.00 20.64 ? 136 PRO C CA  1 
ATOM   4274 C C   . PRO C 3 136 ? -6.041  12.964  9.204   1.00 25.08 ? 136 PRO C C   1 
ATOM   4275 O O   . PRO C 3 136 ? -6.382  11.971  9.848   1.00 23.16 ? 136 PRO C O   1 
ATOM   4276 C CB  . PRO C 3 136 ? -7.684  14.535  8.119   1.00 23.56 ? 136 PRO C CB  1 
ATOM   4277 C CG  . PRO C 3 136 ? -8.874  14.227  7.231   1.00 20.17 ? 136 PRO C CG  1 
ATOM   4278 C CD  . PRO C 3 136 ? -8.985  12.735  7.277   1.00 19.87 ? 136 PRO C CD  1 
ATOM   4279 N N   . SER C 3 137 ? -5.062  13.784  9.590   1.00 22.02 ? 137 SER C N   1 
ATOM   4280 C CA  . SER C 3 137 ? -4.399  13.621  10.873  1.00 24.28 ? 137 SER C CA  1 
ATOM   4281 C C   . SER C 3 137 ? -5.410  13.461  11.993  1.00 21.10 ? 137 SER C C   1 
ATOM   4282 O O   . SER C 3 137 ? -6.337  14.264  12.118  1.00 19.85 ? 137 SER C O   1 
ATOM   4283 C CB  . SER C 3 137 ? -3.541  14.835  11.182  1.00 22.15 ? 137 SER C CB  1 
ATOM   4284 O OG  . SER C 3 137 ? -3.025  14.710  12.496  1.00 25.88 ? 137 SER C OG  1 
ATOM   4285 N N   . SER C 3 138 ? -5.185  12.472  12.855  1.00 21.29 ? 138 SER C N   1 
ATOM   4286 C CA  . SER C 3 138 ? -6.080  12.318  13.996  1.00 24.32 ? 138 SER C CA  1 
ATOM   4287 C C   . SER C 3 138 ? -5.730  13.221  15.175  1.00 21.02 ? 138 SER C C   1 
ATOM   4288 O O   . SER C 3 138 ? -6.446  13.189  16.183  1.00 25.94 ? 138 SER C O   1 
ATOM   4289 C CB  . SER C 3 138 ? -6.109  10.866  14.457  1.00 21.43 ? 138 SER C CB  1 
ATOM   4290 O OG  . SER C 3 138 ? -4.819  10.296  14.397  1.00 26.44 ? 138 SER C OG  1 
ATOM   4291 N N   . GLY C 3 139 ? -4.677  14.011  15.097  1.00 22.31 ? 139 GLY C N   1 
ATOM   4292 C CA  . GLY C 3 139 ? -4.350  14.946  16.165  1.00 15.71 ? 139 GLY C CA  1 
ATOM   4293 C C   . GLY C 3 139 ? -2.847  15.125  16.260  1.00 20.99 ? 139 GLY C C   1 
ATOM   4294 O O   . GLY C 3 139 ? -2.087  14.444  15.597  1.00 20.88 ? 139 GLY C O   1 
ATOM   4295 N N   . GLY C 3 140 ? -2.442  16.037  17.149  1.00 21.45 ? 140 GLY C N   1 
ATOM   4296 C CA  . GLY C 3 140 ? -1.043  16.291  17.457  1.00 22.94 ? 140 GLY C CA  1 
ATOM   4297 C C   . GLY C 3 140 ? -0.743  17.766  17.656  1.00 23.03 ? 140 GLY C C   1 
ATOM   4298 O O   . GLY C 3 140 ? -1.648  18.593  17.532  1.00 21.63 ? 140 GLY C O   1 
ATOM   4299 N N   . ASP C 3 141 ? 0.515   18.115  17.973  1.00 21.45 ? 141 ASP C N   1 
ATOM   4300 C CA  . ASP C 3 141 ? 0.937   19.512  18.017  1.00 21.17 ? 141 ASP C CA  1 
ATOM   4301 C C   . ASP C 3 141 ? 0.723   20.155  16.647  1.00 22.02 ? 141 ASP C C   1 
ATOM   4302 O O   . ASP C 3 141 ? 0.553   19.458  15.651  1.00 25.03 ? 141 ASP C O   1 
ATOM   4303 C CB  . ASP C 3 141 ? 2.425   19.613  18.396  1.00 24.64 ? 141 ASP C CB  1 
ATOM   4304 C CG  . ASP C 3 141 ? 2.692   19.299  19.858  1.00 28.14 ? 141 ASP C CG  1 
ATOM   4305 O OD1 . ASP C 3 141 ? 1.771   19.467  20.681  1.00 29.13 ? 141 ASP C OD1 1 
ATOM   4306 O OD2 . ASP C 3 141 ? 3.830   18.888  20.184  1.00 30.63 ? 141 ASP C OD2 1 
ATOM   4307 N N   . PRO C 3 142 ? 0.739   21.483  16.564  1.00 21.52 ? 142 PRO C N   1 
ATOM   4308 C CA  . PRO C 3 142 ? 0.537   22.122  15.247  1.00 26.75 ? 142 PRO C CA  1 
ATOM   4309 C C   . PRO C 3 142 ? 1.503   21.654  14.183  1.00 25.53 ? 142 PRO C C   1 
ATOM   4310 O O   . PRO C 3 142 ? 1.101   21.539  13.017  1.00 23.93 ? 142 PRO C O   1 
ATOM   4311 C CB  . PRO C 3 142 ? 0.725   23.614  15.550  1.00 26.08 ? 142 PRO C CB  1 
ATOM   4312 C CG  . PRO C 3 142 ? 0.252   23.747  16.978  1.00 26.68 ? 142 PRO C CG  1 
ATOM   4313 C CD  . PRO C 3 142 ? 0.510   22.424  17.675  1.00 18.42 ? 142 PRO C CD  1 
ATOM   4314 N N   . GLU C 3 143 ? 2.760   21.367  14.542  1.00 23.42 ? 143 GLU C N   1 
ATOM   4315 C CA  . GLU C 3 143 ? 3.729   20.957  13.527  1.00 29.88 ? 143 GLU C CA  1 
ATOM   4316 C C   . GLU C 3 143 ? 3.331   19.651  12.885  1.00 24.50 ? 143 GLU C C   1 
ATOM   4317 O O   . GLU C 3 143 ? 3.669   19.408  11.725  1.00 26.32 ? 143 GLU C O   1 
ATOM   4318 C CB  . GLU C 3 143 ? 5.135   20.809  14.122  1.00 27.93 ? 143 GLU C CB  1 
ATOM   4319 C CG  . GLU C 3 143 ? 5.543   21.947  14.988  1.00 34.48 ? 143 GLU C CG  1 
ATOM   4320 C CD  . GLU C 3 143 ? 5.101   21.734  16.418  1.00 37.48 ? 143 GLU C CD  1 
ATOM   4321 O OE1 . GLU C 3 143 ? 5.638   20.813  17.093  1.00 46.00 ? 143 GLU C OE1 1 
ATOM   4322 O OE2 . GLU C 3 143 ? 4.206   22.467  16.856  1.00 37.53 ? 143 GLU C OE2 1 
ATOM   4323 N N   . PHE C 3 144 ? 2.637   18.786  13.620  1.00 25.85 ? 144 PHE C N   1 
ATOM   4324 C CA  . PHE C 3 144 ? 2.364   17.438  13.137  1.00 24.33 ? 144 PHE C CA  1 
ATOM   4325 C C   . PHE C 3 144 ? 0.931   17.216  12.676  1.00 22.42 ? 144 PHE C C   1 
ATOM   4326 O O   . PHE C 3 144 ? 0.699   16.346  11.832  1.00 22.51 ? 144 PHE C O   1 
ATOM   4327 C CB  . PHE C 3 144 ? 2.730   16.409  14.221  1.00 25.18 ? 144 PHE C CB  1 
ATOM   4328 C CG  . PHE C 3 144 ? 4.208   16.352  14.488  1.00 22.95 ? 144 PHE C CG  1 
ATOM   4329 C CD1 . PHE C 3 144 ? 5.059   15.799  13.548  1.00 20.70 ? 144 PHE C CD1 1 
ATOM   4330 C CD2 . PHE C 3 144 ? 4.748   16.924  15.624  1.00 23.06 ? 144 PHE C CD2 1 
ATOM   4331 C CE1 . PHE C 3 144 ? 6.428   15.778  13.758  1.00 21.66 ? 144 PHE C CE1 1 
ATOM   4332 C CE2 . PHE C 3 144 ? 6.124   16.924  15.837  1.00 24.62 ? 144 PHE C CE2 1 
ATOM   4333 C CZ  . PHE C 3 144 ? 6.963   16.338  14.904  1.00 19.10 ? 144 PHE C CZ  1 
ATOM   4334 N N   . VAL C 3 145 ? -0.028  17.986  13.191  1.00 25.06 ? 145 VAL C N   1 
ATOM   4335 C CA  . VAL C 3 145 ? -1.396  17.871  12.686  1.00 24.23 ? 145 VAL C CA  1 
ATOM   4336 C C   . VAL C 3 145 ? -1.524  18.575  11.325  1.00 22.97 ? 145 VAL C C   1 
ATOM   4337 O O   . VAL C 3 145 ? -2.304  18.148  10.463  1.00 21.56 ? 145 VAL C O   1 
ATOM   4338 C CB  . VAL C 3 145 ? -2.385  18.406  13.742  1.00 22.53 ? 145 VAL C CB  1 
ATOM   4339 C CG1 . VAL C 3 145 ? -2.238  19.925  13.975  1.00 21.94 ? 145 VAL C CG1 1 
ATOM   4340 C CG2 . VAL C 3 145 ? -3.826  18.010  13.390  1.00 26.74 ? 145 VAL C CG2 1 
ATOM   4341 N N   . ASN C 3 146 ? -0.718  19.603  11.091  1.00 24.17 ? 146 ASN C N   1 
ATOM   4342 C CA  . ASN C 3 146 ? -0.612  20.287  9.812   1.00 23.64 ? 146 ASN C CA  1 
ATOM   4343 C C   . ASN C 3 146 ? 0.583   19.785  9.012   1.00 26.42 ? 146 ASN C C   1 
ATOM   4344 O O   . ASN C 3 146 ? 1.552   19.247  9.563   1.00 25.31 ? 146 ASN C O   1 
ATOM   4345 C CB  . ASN C 3 146 ? -0.450  21.785  10.027  1.00 24.98 ? 146 ASN C CB  1 
ATOM   4346 C CG  . ASN C 3 146 ? -1.655  22.395  10.673  1.00 23.72 ? 146 ASN C CG  1 
ATOM   4347 O OD1 . ASN C 3 146 ? -2.712  22.472  10.056  1.00 29.14 ? 146 ASN C OD1 1 
ATOM   4348 N ND2 . ASN C 3 146 ? -1.510  22.834  11.917  1.00 18.48 ? 146 ASN C ND2 1 
ATOM   4349 N N   . HIS C 3 147 ? 0.513   19.979  7.694   1.00 23.66 ? 147 HIS C N   1 
ATOM   4350 C CA  . HIS C 3 147 ? 1.739   19.937  6.902   1.00 25.21 ? 147 HIS C CA  1 
ATOM   4351 C C   . HIS C 3 147 ? 2.550   21.172  7.272   1.00 24.03 ? 147 HIS C C   1 
ATOM   4352 O O   . HIS C 3 147 ? 2.137   22.302  6.983   1.00 23.82 ? 147 HIS C O   1 
ATOM   4353 C CB  . HIS C 3 147 ? 1.465   19.883  5.398   1.00 22.84 ? 147 HIS C CB  1 
ATOM   4354 C CG  . HIS C 3 147 ? 2.678   20.175  4.561   1.00 25.16 ? 147 HIS C CG  1 
ATOM   4355 N ND1 . HIS C 3 147 ? 3.900   19.562  4.780   1.00 21.89 ? 147 HIS C ND1 1 
ATOM   4356 C CD2 . HIS C 3 147 ? 2.872   21.034  3.529   1.00 23.49 ? 147 HIS C CD2 1 
ATOM   4357 C CE1 . HIS C 3 147 ? 4.781   20.009  3.899   1.00 24.97 ? 147 HIS C CE1 1 
ATOM   4358 N NE2 . HIS C 3 147 ? 4.189   20.908  3.134   1.00 25.51 ? 147 HIS C NE2 1 
ATOM   4359 N N   . SER C 3 148 ? 3.677   20.964  7.955   1.00 20.30 ? 148 SER C N   1 
ATOM   4360 C CA  . SER C 3 148 ? 4.497   22.052  8.461   1.00 23.94 ? 148 SER C CA  1 
ATOM   4361 C C   . SER C 3 148 ? 5.868   22.011  7.816   1.00 22.70 ? 148 SER C C   1 
ATOM   4362 O O   . SER C 3 148 ? 6.340   20.948  7.403   1.00 24.16 ? 148 SER C O   1 
ATOM   4363 C CB  . SER C 3 148 ? 4.663   21.972  9.966   1.00 24.36 ? 148 SER C CB  1 
ATOM   4364 O OG  . SER C 3 148 ? 3.464   22.419  10.543  1.00 38.77 ? 148 SER C OG  1 
ATOM   4365 N N   . PHE C 3 149 ? 6.505   23.173  7.725   1.00 26.60 ? 149 PHE C N   1 
ATOM   4366 C CA  . PHE C 3 149 ? 7.833   23.181  7.131   1.00 25.18 ? 149 PHE C CA  1 
ATOM   4367 C C   . PHE C 3 149 ? 8.567   24.444  7.546   1.00 22.64 ? 149 PHE C C   1 
ATOM   4368 O O   . PHE C 3 149 ? 7.949   25.475  7.825   1.00 24.59 ? 149 PHE C O   1 
ATOM   4369 C CB  . PHE C 3 149 ? 7.771   23.055  5.597   1.00 22.38 ? 149 PHE C CB  1 
ATOM   4370 C CG  . PHE C 3 149 ? 6.922   24.099  4.911   1.00 26.72 ? 149 PHE C CG  1 
ATOM   4371 C CD1 . PHE C 3 149 ? 5.570   23.883  4.697   1.00 24.74 ? 149 PHE C CD1 1 
ATOM   4372 C CD2 . PHE C 3 149 ? 7.490   25.270  4.428   1.00 26.60 ? 149 PHE C CD2 1 
ATOM   4373 C CE1 . PHE C 3 149 ? 4.789   24.820  4.066   1.00 26.91 ? 149 PHE C CE1 1 
ATOM   4374 C CE2 . PHE C 3 149 ? 6.702   26.212  3.751   1.00 30.79 ? 149 PHE C CE2 1 
ATOM   4375 C CZ  . PHE C 3 149 ? 5.353   25.987  3.588   1.00 32.89 ? 149 PHE C CZ  1 
ATOM   4376 N N   . ASN C 3 150 ? 9.895   24.346  7.606   1.00 24.10 ? 150 ASN C N   1 
ATOM   4377 C CA  . ASN C 3 150 ? 10.737  25.503  7.892   1.00 25.01 ? 150 ASN C CA  1 
ATOM   4378 C C   . ASN C 3 150 ? 11.257  26.011  6.554   1.00 25.55 ? 150 ASN C C   1 
ATOM   4379 O O   . ASN C 3 150 ? 12.024  25.315  5.879   1.00 23.77 ? 150 ASN C O   1 
ATOM   4380 C CB  . ASN C 3 150 ? 11.885  25.150  8.842   1.00 28.71 ? 150 ASN C CB  1 
ATOM   4381 C CG  . ASN C 3 150 ? 12.766  26.370  9.187   1.00 26.29 ? 150 ASN C CG  1 
ATOM   4382 O OD1 . ASN C 3 150 ? 12.889  27.301  8.408   1.00 28.88 ? 150 ASN C OD1 1 
ATOM   4383 N ND2 . ASN C 3 150 ? 13.367  26.352  10.349  1.00 27.37 ? 150 ASN C ND2 1 
ATOM   4384 N N   . CYS C 3 151 ? 10.813  27.202  6.150   1.00 26.42 ? 151 CYS C N   1 
ATOM   4385 C CA  . CYS C 3 151 ? 11.345  27.859  4.963   1.00 30.71 ? 151 CYS C CA  1 
ATOM   4386 C C   . CYS C 3 151 ? 12.090  29.120  5.371   1.00 28.93 ? 151 CYS C C   1 
ATOM   4387 O O   . CYS C 3 151 ? 11.515  30.009  6.009   1.00 31.44 ? 151 CYS C O   1 
ATOM   4388 C CB  . CYS C 3 151 ? 10.245  28.205  3.962   1.00 30.50 ? 151 CYS C CB  1 
ATOM   4389 S SG  . CYS C 3 151 ? 10.873  29.171  2.540   1.00 28.65 ? 151 CYS C SG  1 
ATOM   4390 N N   . GLY C 3 152 ? 13.365  29.203  4.996   1.00 27.41 ? 152 GLY C N   1 
ATOM   4391 C CA  . GLY C 3 152 ? 14.101  30.432  5.218   1.00 28.70 ? 152 GLY C CA  1 
ATOM   4392 C C   . GLY C 3 152 ? 14.323  30.799  6.661   1.00 31.08 ? 152 GLY C C   1 
ATOM   4393 O O   . GLY C 3 152 ? 14.648  31.955  6.955   1.00 38.99 ? 152 GLY C O   1 
ATOM   4394 N N   . GLY C 3 153 ? 14.164  29.852  7.575   1.00 31.30 ? 153 GLY C N   1 
ATOM   4395 C CA  . GLY C 3 153 ? 14.242  30.129  8.992   1.00 27.70 ? 153 GLY C CA  1 
ATOM   4396 C C   . GLY C 3 153 ? 12.915  30.396  9.668   1.00 32.78 ? 153 GLY C C   1 
ATOM   4397 O O   . GLY C 3 153 ? 12.895  30.617  10.880  1.00 35.43 ? 153 GLY C O   1 
ATOM   4398 N N   . GLU C 3 154 ? 11.807  30.383  8.930   1.00 34.80 ? 154 GLU C N   1 
ATOM   4399 C CA  . GLU C 3 154 ? 10.479  30.606  9.490   1.00 31.26 ? 154 GLU C CA  1 
ATOM   4400 C C   . GLU C 3 154 ? 9.611   29.369  9.298   1.00 29.78 ? 154 GLU C C   1 
ATOM   4401 O O   . GLU C 3 154 ? 9.667   28.710  8.252   1.00 27.80 ? 154 GLU C O   1 
ATOM   4402 C CB  . GLU C 3 154 ? 9.798   31.816  8.839   1.00 33.65 ? 154 GLU C CB  1 
ATOM   4403 C CG  . GLU C 3 154 ? 8.401   32.097  9.352   1.00 38.64 ? 154 GLU C CG  1 
ATOM   4404 C CD  . GLU C 3 154 ? 7.804   33.338  8.732   1.00 44.09 ? 154 GLU C CD  1 
ATOM   4405 O OE1 . GLU C 3 154 ? 8.393   33.875  7.768   1.00 51.18 ? 154 GLU C OE1 1 
ATOM   4406 O OE2 . GLU C 3 154 ? 6.741   33.780  9.212   1.00 49.80 ? 154 GLU C OE2 1 
ATOM   4407 N N   . PHE C 3 155 ? 8.790   29.074  10.301  1.00 28.54 ? 155 PHE C N   1 
ATOM   4408 C CA  . PHE C 3 155 ? 7.952   27.882  10.305  1.00 28.91 ? 155 PHE C CA  1 
ATOM   4409 C C   . PHE C 3 155 ? 6.557   28.241  9.785   1.00 26.82 ? 155 PHE C C   1 
ATOM   4410 O O   . PHE C 3 155 ? 5.966   29.230  10.215  1.00 26.34 ? 155 PHE C O   1 
ATOM   4411 C CB  . PHE C 3 155 ? 7.893   27.294  11.714  1.00 29.55 ? 155 PHE C CB  1 
ATOM   4412 C CG  . PHE C 3 155 ? 8.158   25.818  11.763  1.00 33.53 ? 155 PHE C CG  1 
ATOM   4413 C CD1 . PHE C 3 155 ? 9.456   25.312  11.846  1.00 33.77 ? 155 PHE C CD1 1 
ATOM   4414 C CD2 . PHE C 3 155 ? 7.107   24.923  11.708  1.00 35.68 ? 155 PHE C CD2 1 
ATOM   4415 C CE1 . PHE C 3 155 ? 9.682   23.928  11.883  1.00 34.73 ? 155 PHE C CE1 1 
ATOM   4416 C CE2 . PHE C 3 155 ? 7.327   23.559  11.746  1.00 29.13 ? 155 PHE C CE2 1 
ATOM   4417 C CZ  . PHE C 3 155 ? 8.611   23.061  11.822  1.00 36.27 ? 155 PHE C CZ  1 
ATOM   4418 N N   . PHE C 3 156 ? 6.061   27.458  8.837   1.00 24.39 ? 156 PHE C N   1 
ATOM   4419 C CA  . PHE C 3 156 ? 4.750   27.647  8.227   1.00 28.68 ? 156 PHE C CA  1 
ATOM   4420 C C   . PHE C 3 156 ? 3.909   26.390  8.392   1.00 24.09 ? 156 PHE C C   1 
ATOM   4421 O O   . PHE C 3 156 ? 4.444   25.283  8.467   1.00 25.00 ? 156 PHE C O   1 
ATOM   4422 C CB  . PHE C 3 156 ? 4.867   27.965  6.743   1.00 24.38 ? 156 PHE C CB  1 
ATOM   4423 C CG  . PHE C 3 156 ? 5.675   29.167  6.469   1.00 30.14 ? 156 PHE C CG  1 
ATOM   4424 C CD1 . PHE C 3 156 ? 7.060   29.078  6.353   1.00 30.00 ? 156 PHE C CD1 1 
ATOM   4425 C CD2 . PHE C 3 156 ? 5.072   30.399  6.340   1.00 30.39 ? 156 PHE C CD2 1 
ATOM   4426 C CE1 . PHE C 3 156 ? 7.820   30.206  6.095   1.00 29.79 ? 156 PHE C CE1 1 
ATOM   4427 C CE2 . PHE C 3 156 ? 5.825   31.528  6.090   1.00 34.73 ? 156 PHE C CE2 1 
ATOM   4428 C CZ  . PHE C 3 156 ? 7.209   31.430  5.974   1.00 29.99 ? 156 PHE C CZ  1 
ATOM   4429 N N   . TYR C 3 157 ? 2.585   26.565  8.399   1.00 28.13 ? 157 TYR C N   1 
ATOM   4430 C CA  . TYR C 3 157 ? 1.644   25.501  8.741   1.00 21.36 ? 157 TYR C CA  1 
ATOM   4431 C C   . TYR C 3 157 ? 0.517   25.471  7.721   1.00 24.28 ? 157 TYR C C   1 
ATOM   4432 O O   . TYR C 3 157 ? -0.239  26.440  7.616   1.00 25.59 ? 157 TYR C O   1 
ATOM   4433 C CB  . TYR C 3 157 ? 1.070   25.736  10.144  1.00 26.00 ? 157 TYR C CB  1 
ATOM   4434 C CG  . TYR C 3 157 ? 2.116   25.863  11.223  1.00 23.10 ? 157 TYR C CG  1 
ATOM   4435 C CD1 . TYR C 3 157 ? 2.753   27.072  11.469  1.00 27.93 ? 157 TYR C CD1 1 
ATOM   4436 C CD2 . TYR C 3 157 ? 2.438   24.775  12.024  1.00 26.75 ? 157 TYR C CD2 1 
ATOM   4437 C CE1 . TYR C 3 157 ? 3.703   27.191  12.474  1.00 26.64 ? 157 TYR C CE1 1 
ATOM   4438 C CE2 . TYR C 3 157 ? 3.387   24.874  13.030  1.00 28.94 ? 157 TYR C CE2 1 
ATOM   4439 C CZ  . TYR C 3 157 ? 4.022   26.085  13.249  1.00 35.11 ? 157 TYR C CZ  1 
ATOM   4440 O OH  . TYR C 3 157 ? 4.973   26.185  14.245  1.00 35.85 ? 157 TYR C OH  1 
ATOM   4441 N N   . CYS C 3 158 ? 0.388   24.360  6.993   1.00 23.23 ? 158 CYS C N   1 
ATOM   4442 C CA  . CYS C 3 158 ? -0.678  24.193  6.012   1.00 24.12 ? 158 CYS C CA  1 
ATOM   4443 C C   . CYS C 3 158 ? -1.597  23.059  6.441   1.00 24.72 ? 158 CYS C C   1 
ATOM   4444 O O   . CYS C 3 158 ? -1.142  21.927  6.661   1.00 24.25 ? 158 CYS C O   1 
ATOM   4445 C CB  . CYS C 3 158 ? -0.123  23.916  4.619   1.00 24.13 ? 158 CYS C CB  1 
ATOM   4446 S SG  . CYS C 3 158 ? 0.882   25.266  3.938   1.00 25.54 ? 158 CYS C SG  1 
ATOM   4447 N N   . ALA C 3 159 ? -2.889  23.365  6.544   1.00 22.30 ? 159 ALA C N   1 
ATOM   4448 C CA  . ALA C 3 159 ? -3.887  22.329  6.753   1.00 17.52 ? 159 ALA C CA  1 
ATOM   4449 C C   . ALA C 3 159 ? -3.852  21.366  5.585   1.00 21.47 ? 159 ALA C C   1 
ATOM   4450 O O   . ALA C 3 159 ? -3.843  21.790  4.424   1.00 22.15 ? 159 ALA C O   1 
ATOM   4451 C CB  . ALA C 3 159 ? -5.265  22.973  6.905   1.00 21.40 ? 159 ALA C CB  1 
ATOM   4452 N N   . SER C 3 160 ? -3.779  20.067  5.889   1.00 19.38 ? 160 SER C N   1 
ATOM   4453 C CA  . SER C 3 160 ? -3.634  19.036  4.864   1.00 20.51 ? 160 SER C CA  1 
ATOM   4454 C C   . SER C 3 160 ? -4.858  18.136  4.737   1.00 18.11 ? 160 SER C C   1 
ATOM   4455 O O   . SER C 3 160 ? -4.777  17.101  4.060   1.00 18.41 ? 160 SER C O   1 
ATOM   4456 C CB  . SER C 3 160 ? -2.402  18.177  5.136   1.00 20.21 ? 160 SER C CB  1 
ATOM   4457 O OG  . SER C 3 160 ? -2.540  17.514  6.384   1.00 23.64 ? 160 SER C OG  1 
ATOM   4458 N N   . THR C 3 161 ? -5.993  18.535  5.340   1.00 21.72 ? 161 THR C N   1 
ATOM   4459 C CA  . THR C 3 161 ? -7.248  17.777  5.236   1.00 17.68 ? 161 THR C CA  1 
ATOM   4460 C C   . THR C 3 161 ? -7.572  17.430  3.793   1.00 17.99 ? 161 THR C C   1 
ATOM   4461 O O   . THR C 3 161 ? -7.873  16.275  3.471   1.00 22.57 ? 161 THR C O   1 
ATOM   4462 C CB  . THR C 3 161 ? -8.397  18.592  5.842   1.00 25.17 ? 161 THR C CB  1 
ATOM   4463 O OG1 . THR C 3 161 ? -8.029  19.073  7.139   1.00 25.25 ? 161 THR C OG1 1 
ATOM   4464 C CG2 . THR C 3 161 ? -9.687  17.757  5.951   1.00 24.10 ? 161 THR C CG2 1 
ATOM   4465 N N   . GLN C 3 162 ? -7.463  18.423  2.896   1.00 20.46 ? 162 GLN C N   1 
ATOM   4466 C CA  . GLN C 3 162 ? -7.791  18.230  1.486   1.00 19.62 ? 162 GLN C CA  1 
ATOM   4467 C C   . GLN C 3 162 ? -6.929  17.182  0.793   1.00 22.05 ? 162 GLN C C   1 
ATOM   4468 O O   . GLN C 3 162 ? -7.342  16.623  -0.240  1.00 17.37 ? 162 GLN C O   1 
ATOM   4469 C CB  . GLN C 3 162 ? -7.645  19.553  0.763   1.00 21.69 ? 162 GLN C CB  1 
ATOM   4470 C CG  . GLN C 3 162 ? -8.678  20.539  1.154   1.00 19.03 ? 162 GLN C CG  1 
ATOM   4471 C CD  . GLN C 3 162 ? -8.216  21.930  0.892   1.00 23.40 ? 162 GLN C CD  1 
ATOM   4472 O OE1 . GLN C 3 162 ? -7.633  22.572  1.768   1.00 22.88 ? 162 GLN C OE1 1 
ATOM   4473 N NE2 . GLN C 3 162 ? -8.466  22.421  -0.332  1.00 21.96 ? 162 GLN C NE2 1 
ATOM   4474 N N   . LEU C 3 163 ? -5.707  16.950  1.300   1.00 21.04 ? 163 LEU C N   1 
ATOM   4475 C CA  . LEU C 3 163 ? -4.784  15.983  0.709   1.00 19.89 ? 163 LEU C CA  1 
ATOM   4476 C C   . LEU C 3 163 ? -5.017  14.550  1.174   1.00 20.93 ? 163 LEU C C   1 
ATOM   4477 O O   . LEU C 3 163 ? -4.564  13.610  0.510   1.00 20.08 ? 163 LEU C O   1 
ATOM   4478 C CB  . LEU C 3 163 ? -3.328  16.372  1.049   1.00 17.35 ? 163 LEU C CB  1 
ATOM   4479 C CG  . LEU C 3 163 ? -2.801  17.727  0.588   1.00 22.13 ? 163 LEU C CG  1 
ATOM   4480 C CD1 . LEU C 3 163 ? -1.313  17.807  0.805   1.00 19.14 ? 163 LEU C CD1 1 
ATOM   4481 C CD2 . LEU C 3 163 ? -3.118  17.903  -0.872  1.00 19.26 ? 163 LEU C CD2 1 
ATOM   4482 N N   . PHE C 3 164 ? -5.648  14.350  2.335   1.00 21.31 ? 164 PHE C N   1 
ATOM   4483 C CA  . PHE C 3 164 ? -5.840  13.018  2.873   1.00 17.82 ? 164 PHE C CA  1 
ATOM   4484 C C   . PHE C 3 164 ? -7.318  12.876  3.252   1.00 22.47 ? 164 PHE C C   1 
ATOM   4485 O O   . PHE C 3 164 ? -7.667  12.856  4.436   1.00 18.24 ? 164 PHE C O   1 
ATOM   4486 C CB  . PHE C 3 164 ? -4.964  12.795  4.111   1.00 20.18 ? 164 PHE C CB  1 
ATOM   4487 C CG  . PHE C 3 164 ? -3.493  13.037  3.891   1.00 17.30 ? 164 PHE C CG  1 
ATOM   4488 C CD1 . PHE C 3 164 ? -2.702  12.085  3.261   1.00 16.58 ? 164 PHE C CD1 1 
ATOM   4489 C CD2 . PHE C 3 164 ? -2.905  14.209  4.345   1.00 19.38 ? 164 PHE C CD2 1 
ATOM   4490 C CE1 . PHE C 3 164 ? -1.312  12.299  3.073   1.00 21.40 ? 164 PHE C CE1 1 
ATOM   4491 C CE2 . PHE C 3 164 ? -1.528  14.439  4.163   1.00 21.52 ? 164 PHE C CE2 1 
ATOM   4492 C CZ  . PHE C 3 164 ? -0.743  13.475  3.517   1.00 22.05 ? 164 PHE C CZ  1 
ATOM   4493 N N   . ALA C 3 165 ? -8.175  12.771  2.244   1.00 20.18 ? 165 ALA C N   1 
ATOM   4494 C CA  . ALA C 3 165 ? -9.565  12.390  2.464   1.00 24.38 ? 165 ALA C CA  1 
ATOM   4495 C C   . ALA C 3 165 ? -10.108 11.848  1.157   1.00 24.56 ? 165 ALA C C   1 
ATOM   4496 O O   . ALA C 3 165 ? -10.834 12.553  0.447   1.00 25.24 ? 165 ALA C O   1 
ATOM   4497 C CB  . ALA C 3 165 ? -10.371 13.595  2.956   1.00 20.85 ? 165 ALA C CB  1 
ATOM   4498 N N   . SER C 3 166 ? -9.829  10.585  0.869   1.00 16.45 ? 166 SER C N   1 
ATOM   4499 C CA  . SER C 3 166 ? -10.256 9.993   -0.385  1.00 24.20 ? 166 SER C CA  1 
ATOM   4500 C C   . SER C 3 166 ? -10.082 8.488   -0.274  1.00 24.36 ? 166 SER C C   1 
ATOM   4501 O O   . SER C 3 166 ? -9.303  7.984   0.550   1.00 21.54 ? 166 SER C O   1 
ATOM   4502 C CB  . SER C 3 166 ? -9.469  10.546  -1.586  1.00 23.62 ? 166 SER C CB  1 
ATOM   4503 O OG  . SER C 3 166 ? -8.069  10.439  -1.362  1.00 25.85 ? 166 SER C OG  1 
ATOM   4504 N N   . THR C 3 167 ? -10.780 7.787   -1.154  1.00 20.84 ? 167 THR C N   1 
ATOM   4505 C CA  . THR C 3 167 ? -10.904 6.344   -1.112  1.00 23.33 ? 167 THR C CA  1 
ATOM   4506 C C   . THR C 3 167 ? -10.412 5.821   -2.445  1.00 25.18 ? 167 THR C C   1 
ATOM   4507 O O   . THR C 3 167 ? -10.526 6.498   -3.468  1.00 25.77 ? 167 THR C O   1 
ATOM   4508 C CB  . THR C 3 167 ? -12.394 5.913   -0.812  1.00 23.04 ? 167 THR C CB  1 
ATOM   4509 O OG1 . THR C 3 167 ? -12.678 6.105   0.581   1.00 24.10 ? 167 THR C OG1 1 
ATOM   4510 C CG2 . THR C 3 167 ? -12.645 4.451   -1.143  1.00 26.71 ? 167 THR C CG2 1 
ATOM   4511 N N   . TRP C 3 168 ? -9.811  4.639   -2.429  1.00 24.53 ? 168 TRP C N   1 
ATOM   4512 C CA  . TRP C 3 168 ? -9.178  4.110   -3.632  1.00 24.77 ? 168 TRP C CA  1 
ATOM   4513 C C   . TRP C 3 168 ? -9.509  2.635   -3.735  1.00 26.06 ? 168 TRP C C   1 
ATOM   4514 O O   . TRP C 3 168 ? -9.030  1.839   -2.923  1.00 31.72 ? 168 TRP C O   1 
ATOM   4515 C CB  . TRP C 3 168 ? -7.666  4.362   -3.591  1.00 23.17 ? 168 TRP C CB  1 
ATOM   4516 C CG  . TRP C 3 168 ? -7.412  5.840   -3.517  1.00 22.71 ? 168 TRP C CG  1 
ATOM   4517 C CD1 . TRP C 3 168 ? -7.277  6.589   -2.399  1.00 23.35 ? 168 TRP C CD1 1 
ATOM   4518 C CD2 . TRP C 3 168 ? -7.367  6.748   -4.620  1.00 20.93 ? 168 TRP C CD2 1 
ATOM   4519 N NE1 . TRP C 3 168 ? -7.114  7.914   -2.733  1.00 25.12 ? 168 TRP C NE1 1 
ATOM   4520 C CE2 . TRP C 3 168 ? -7.159  8.029   -4.098  1.00 23.08 ? 168 TRP C CE2 1 
ATOM   4521 C CE3 . TRP C 3 168 ? -7.450  6.588   -6.011  1.00 26.61 ? 168 TRP C CE3 1 
ATOM   4522 C CZ2 . TRP C 3 168 ? -7.038  9.159   -4.911  1.00 23.71 ? 168 TRP C CZ2 1 
ATOM   4523 C CZ3 . TRP C 3 168 ? -7.326  7.705   -6.812  1.00 26.93 ? 168 TRP C CZ3 1 
ATOM   4524 C CH2 . TRP C 3 168 ? -7.130  8.975   -6.257  1.00 28.15 ? 168 TRP C CH2 1 
ATOM   4525 N N   . PHE C 3 169 ? -10.342 2.267   -4.710  1.00 30.50 ? 169 PHE C N   1 
ATOM   4526 C CA  . PHE C 3 169 ? -10.687 0.853   -4.891  1.00 34.82 ? 169 PHE C CA  1 
ATOM   4527 C C   . PHE C 3 169 ? -9.605  0.177   -5.728  1.00 36.24 ? 169 PHE C C   1 
ATOM   4528 O O   . PHE C 3 169 ? -9.374  -1.026  -5.598  1.00 43.28 ? 169 PHE C O   1 
ATOM   4529 C CB  . PHE C 3 169 ? -12.056 0.670   -5.564  1.00 37.47 ? 169 PHE C CB  1 
ATOM   4530 C CG  . PHE C 3 169 ? -13.214 1.313   -4.828  1.00 37.40 ? 169 PHE C CG  1 
ATOM   4531 C CD1 . PHE C 3 169 ? -13.292 1.284   -3.445  1.00 37.52 ? 169 PHE C CD1 1 
ATOM   4532 C CD2 . PHE C 3 169 ? -14.248 1.936   -5.540  1.00 40.60 ? 169 PHE C CD2 1 
ATOM   4533 C CE1 . PHE C 3 169 ? -14.381 1.867   -2.776  1.00 34.55 ? 169 PHE C CE1 1 
ATOM   4534 C CE2 . PHE C 3 169 ? -15.339 2.523   -4.879  1.00 35.35 ? 169 PHE C CE2 1 
ATOM   4535 C CZ  . PHE C 3 169 ? -15.404 2.493   -3.500  1.00 36.06 ? 169 PHE C CZ  1 
HETATM 4536 C C1  . NAG D 4 .   ? 10.387  21.213  -9.033  1.00 31.51 ? 201 NAG C C1  1 
HETATM 4537 C C2  . NAG D 4 .   ? 10.739  22.708  -9.041  1.00 31.33 ? 201 NAG C C2  1 
HETATM 4538 C C3  . NAG D 4 .   ? 10.847  23.236  -10.471 1.00 31.49 ? 201 NAG C C3  1 
HETATM 4539 C C4  . NAG D 4 .   ? 11.762  22.353  -11.310 1.00 31.59 ? 201 NAG C C4  1 
HETATM 4540 C C5  . NAG D 4 .   ? 11.256  20.912  -11.233 1.00 31.79 ? 201 NAG C C5  1 
HETATM 4541 C C6  . NAG D 4 .   ? 12.086  19.933  -12.035 1.00 31.86 ? 201 NAG C C6  1 
HETATM 4542 C C7  . NAG D 4 .   ? 9.946   23.992  -7.092  1.00 29.25 ? 201 NAG C C7  1 
HETATM 4543 C C8  . NAG D 4 .   ? 8.770   24.757  -6.536  1.00 28.81 ? 201 NAG C C8  1 
HETATM 4544 N N2  . NAG D 4 .   ? 9.758   23.470  -8.316  1.00 30.79 ? 201 NAG C N2  1 
HETATM 4545 O O3  . NAG D 4 .   ? 11.310  24.559  -10.412 1.00 31.43 ? 201 NAG C O3  1 
HETATM 4546 O O4  . NAG D 4 .   ? 11.734  22.847  -12.629 1.00 31.54 ? 201 NAG C O4  1 
HETATM 4547 O O5  . NAG D 4 .   ? 11.267  20.507  -9.880  1.00 31.59 ? 201 NAG C O5  1 
HETATM 4548 O O6  . NAG D 4 .   ? 11.676  18.617  -11.750 1.00 31.77 ? 201 NAG C O6  1 
HETATM 4549 O O7  . NAG D 4 .   ? 10.983  23.865  -6.459  1.00 28.19 ? 201 NAG C O7  1 
HETATM 4550 C C1  . NAG E 4 .   ? 12.463  24.009  -2.327  1.00 24.69 ? 202 NAG C C1  1 
HETATM 4551 C C2  . NAG E 4 .   ? 12.545  25.180  -1.331  1.00 25.02 ? 202 NAG C C2  1 
HETATM 4552 C C3  . NAG E 4 .   ? 12.322  26.536  -2.002  1.00 25.71 ? 202 NAG C C3  1 
HETATM 4553 C C4  . NAG E 4 .   ? 13.161  26.673  -3.262  1.00 25.45 ? 202 NAG C C4  1 
HETATM 4554 C C5  . NAG E 4 .   ? 12.826  25.498  -4.177  1.00 25.80 ? 202 NAG C C5  1 
HETATM 4555 C C6  . NAG E 4 .   ? 13.560  25.537  -5.498  1.00 25.52 ? 202 NAG C C6  1 
HETATM 4556 C C7  . NAG E 4 .   ? 11.777  25.380  1.006   1.00 24.92 ? 202 NAG C C7  1 
HETATM 4557 C C8  . NAG E 4 .   ? 10.616  25.112  1.932   1.00 24.92 ? 202 NAG C C8  1 
HETATM 4558 N N2  . NAG E 4 .   ? 11.581  25.017  -0.275  1.00 25.24 ? 202 NAG C N2  1 
HETATM 4559 O O3  . NAG E 4 .   ? 12.615  27.543  -1.070  1.00 25.49 ? 202 NAG C O3  1 
HETATM 4560 O O4  . NAG E 4 .   ? 12.834  27.909  -3.855  1.00 26.48 ? 202 NAG C O4  1 
HETATM 4561 O O5  . NAG E 4 .   ? 13.175  24.304  -3.510  1.00 25.09 ? 202 NAG C O5  1 
HETATM 4562 O O6  . NAG E 4 .   ? 14.946  25.457  -5.267  1.00 23.80 ? 202 NAG C O6  1 
HETATM 4563 O O7  . NAG E 4 .   ? 12.811  25.890  1.410   1.00 24.38 ? 202 NAG C O7  1 
HETATM 4564 O O   . HOH F 5 .   ? -29.333 -24.474 60.454  1.00 27.46 ? 301 HOH H O   1 
HETATM 4565 O O   . HOH F 5 .   ? 9.165   8.401   17.291  1.00 29.01 ? 302 HOH H O   1 
HETATM 4566 O O   . HOH F 5 .   ? -13.015 -9.496  26.928  1.00 40.18 ? 303 HOH H O   1 
HETATM 4567 O O   . HOH F 5 .   ? -15.981 4.353   42.020  1.00 21.56 ? 304 HOH H O   1 
HETATM 4568 O O   . HOH F 5 .   ? -19.831 9.188   43.680  1.00 32.83 ? 305 HOH H O   1 
HETATM 4569 O O   . HOH F 5 .   ? -23.180 -12.265 68.876  1.00 33.04 ? 306 HOH H O   1 
HETATM 4570 O O   . HOH F 5 .   ? -9.961  10.028  36.673  1.00 26.30 ? 307 HOH H O   1 
HETATM 4571 O O   . HOH F 5 .   ? -15.652 -2.603  64.583  1.00 33.30 ? 308 HOH H O   1 
HETATM 4572 O O   . HOH F 5 .   ? -32.661 -1.325  43.906  1.00 34.01 ? 309 HOH H O   1 
HETATM 4573 O O   . HOH F 5 .   ? -2.670  10.207  26.373  1.00 23.40 ? 310 HOH H O   1 
HETATM 4574 O O   . HOH F 5 .   ? -16.840 4.610   39.253  1.00 25.47 ? 311 HOH H O   1 
HETATM 4575 O O   . HOH F 5 .   ? 10.466  12.714  31.583  1.00 36.40 ? 312 HOH H O   1 
HETATM 4576 O O   . HOH F 5 .   ? -14.135 -8.493  53.435  1.00 30.58 ? 313 HOH H O   1 
HETATM 4577 O O   . HOH F 5 .   ? -15.410 2.171   48.646  1.00 29.63 ? 314 HOH H O   1 
HETATM 4578 O O   . HOH F 5 .   ? -25.953 1.456   37.162  1.00 25.05 ? 315 HOH H O   1 
HETATM 4579 O O   . HOH F 5 .   ? -6.826  14.133  26.266  1.00 29.37 ? 316 HOH H O   1 
HETATM 4580 O O   . HOH F 5 .   ? -7.753  5.259   39.954  1.00 24.25 ? 317 HOH H O   1 
HETATM 4581 O O   . HOH F 5 .   ? -10.820 10.588  17.968  1.00 26.83 ? 318 HOH H O   1 
HETATM 4582 O O   . HOH F 5 .   ? -15.348 -15.145 67.086  1.00 38.28 ? 319 HOH H O   1 
HETATM 4583 O O   . HOH F 5 .   ? -2.606  8.419   13.178  1.00 22.36 ? 320 HOH H O   1 
HETATM 4584 O O   . HOH F 5 .   ? -12.505 -8.075  58.673  1.00 31.42 ? 321 HOH H O   1 
HETATM 4585 O O   . HOH F 5 .   ? -12.862 -5.089  27.912  1.00 31.59 ? 322 HOH H O   1 
HETATM 4586 O O   . HOH F 5 .   ? 11.942  -0.272  19.414  1.00 40.71 ? 323 HOH H O   1 
HETATM 4587 O O   . HOH F 5 .   ? -29.364 2.707   49.841  1.00 29.24 ? 324 HOH H O   1 
HETATM 4588 O O   . HOH F 5 .   ? -13.723 -15.232 50.384  1.00 39.27 ? 325 HOH H O   1 
HETATM 4589 O O   . HOH F 5 .   ? -23.814 7.940   37.003  1.00 29.99 ? 326 HOH H O   1 
HETATM 4590 O O   . HOH F 5 .   ? -5.030  17.768  27.667  1.00 28.27 ? 327 HOH H O   1 
HETATM 4591 O O   . HOH F 5 .   ? -2.300  14.716  21.368  1.00 26.97 ? 328 HOH H O   1 
HETATM 4592 O O   . HOH F 5 .   ? 0.863   3.123   40.119  1.00 32.42 ? 329 HOH H O   1 
HETATM 4593 O O   . HOH F 5 .   ? 11.967  1.924   20.491  1.00 28.84 ? 330 HOH H O   1 
HETATM 4594 O O   . HOH F 5 .   ? -20.498 -2.663  36.898  1.00 35.16 ? 331 HOH H O   1 
HETATM 4595 O O   . HOH F 5 .   ? -23.488 0.861   36.862  1.00 26.17 ? 332 HOH H O   1 
HETATM 4596 O O   . HOH F 5 .   ? -25.762 3.857   28.408  1.00 35.15 ? 333 HOH H O   1 
HETATM 4597 O O   . HOH F 5 .   ? -13.967 -12.698 51.136  1.00 35.61 ? 334 HOH H O   1 
HETATM 4598 O O   . HOH F 5 .   ? -16.125 6.847   53.570  1.00 30.85 ? 335 HOH H O   1 
HETATM 4599 O O   . HOH F 5 .   ? -7.863  12.103  40.953  1.00 27.42 ? 336 HOH H O   1 
HETATM 4600 O O   . HOH F 5 .   ? -20.073 3.374   24.377  1.00 24.68 ? 337 HOH H O   1 
HETATM 4601 O O   . HOH F 5 .   ? -8.839  16.234  25.923  1.00 28.53 ? 338 HOH H O   1 
HETATM 4602 O O   . HOH F 5 .   ? -19.622 13.653  25.500  1.00 28.03 ? 339 HOH H O   1 
HETATM 4603 O O   . HOH F 5 .   ? -6.025  7.770   15.021  1.00 22.57 ? 340 HOH H O   1 
HETATM 4604 O O   . HOH F 5 .   ? -9.916  -13.913 62.582  1.00 36.52 ? 341 HOH H O   1 
HETATM 4605 O O   . HOH F 5 .   ? -9.621  14.169  19.117  1.00 34.36 ? 342 HOH H O   1 
HETATM 4606 O O   . HOH F 5 .   ? 3.871   13.073  17.109  1.00 25.60 ? 343 HOH H O   1 
HETATM 4607 O O   . HOH F 5 .   ? 0.663   0.428   38.854  1.00 31.75 ? 344 HOH H O   1 
HETATM 4608 O O   . HOH F 5 .   ? -18.042 1.068   24.108  1.00 34.22 ? 345 HOH H O   1 
HETATM 4609 O O   . HOH F 5 .   ? -19.826 4.609   60.892  1.00 32.68 ? 346 HOH H O   1 
HETATM 4610 O O   . HOH F 5 .   ? -12.602 10.587  13.440  1.00 29.27 ? 347 HOH H O   1 
HETATM 4611 O O   . HOH F 5 .   ? -27.980 3.531   32.889  1.00 39.27 ? 348 HOH H O   1 
HETATM 4612 O O   . HOH F 5 .   ? -19.662 0.839   39.501  1.00 25.51 ? 349 HOH H O   1 
HETATM 4613 O O   . HOH F 5 .   ? 5.870   7.821   28.100  1.00 35.71 ? 350 HOH H O   1 
HETATM 4614 O O   . HOH F 5 .   ? 3.681   2.003   37.552  1.00 32.92 ? 351 HOH H O   1 
HETATM 4615 O O   . HOH F 5 .   ? -13.336 -10.098 66.927  1.00 36.96 ? 352 HOH H O   1 
HETATM 4616 O O   . HOH F 5 .   ? -14.237 -5.900  51.204  1.00 32.15 ? 353 HOH H O   1 
HETATM 4617 O O   . HOH F 5 .   ? -24.439 -8.184  38.159  1.00 32.82 ? 354 HOH H O   1 
HETATM 4618 O O   . HOH F 5 .   ? -26.364 8.584   50.080  1.00 29.70 ? 355 HOH H O   1 
HETATM 4619 O O   . HOH F 5 .   ? -22.826 0.593   33.988  1.00 28.52 ? 356 HOH H O   1 
HETATM 4620 O O   . HOH F 5 .   ? -1.058  16.295  23.315  1.00 21.75 ? 357 HOH H O   1 
HETATM 4621 O O   . HOH F 5 .   ? -19.450 -23.394 69.408  1.00 35.43 ? 358 HOH H O   1 
HETATM 4622 O O   . HOH F 5 .   ? -10.246 4.094   40.245  1.00 25.06 ? 359 HOH H O   1 
HETATM 4623 O O   . HOH F 5 .   ? -12.883 13.140  23.280  1.00 29.22 ? 360 HOH H O   1 
HETATM 4624 O O   . HOH F 5 .   ? -16.579 11.950  38.493  1.00 36.51 ? 361 HOH H O   1 
HETATM 4625 O O   . HOH F 5 .   ? -17.568 -5.773  44.364  1.00 31.99 ? 362 HOH H O   1 
HETATM 4626 O O   . HOH F 5 .   ? -19.174 15.734  30.497  1.00 33.73 ? 363 HOH H O   1 
HETATM 4627 O O   . HOH F 5 .   ? -23.888 11.095  40.831  1.00 35.19 ? 364 HOH H O   1 
HETATM 4628 O O   . HOH F 5 .   ? -23.458 -10.499 46.676  1.00 31.45 ? 365 HOH H O   1 
HETATM 4629 O O   . HOH F 5 .   ? -4.913  15.317  36.996  1.00 47.69 ? 366 HOH H O   1 
HETATM 4630 O O   . HOH F 5 .   ? -19.612 -5.258  39.542  1.00 46.13 ? 367 HOH H O   1 
HETATM 4631 O O   . HOH F 5 .   ? -21.477 -24.868 70.987  1.00 47.38 ? 368 HOH H O   1 
HETATM 4632 O O   . HOH F 5 .   ? -13.845 13.219  20.538  1.00 40.31 ? 369 HOH H O   1 
HETATM 4633 O O   . HOH F 5 .   ? -20.728 4.548   22.061  1.00 33.27 ? 370 HOH H O   1 
HETATM 4634 O O   . HOH F 5 .   ? -14.344 -16.425 65.050  1.00 32.34 ? 371 HOH H O   1 
HETATM 4635 O O   . HOH F 5 .   ? -21.176 -2.972  34.367  1.00 39.10 ? 372 HOH H O   1 
HETATM 4636 O O   . HOH G 5 .   ? -2.942  -3.637  13.020  1.00 29.50 ? 301 HOH L O   1 
HETATM 4637 O O   . HOH G 5 .   ? -35.279 -16.013 40.757  1.00 32.14 ? 302 HOH L O   1 
HETATM 4638 O O   . HOH G 5 .   ? -14.123 -18.420 48.558  1.00 37.97 ? 303 HOH L O   1 
HETATM 4639 O O   . HOH G 5 .   ? -14.959 -20.820 49.714  1.00 29.37 ? 304 HOH L O   1 
HETATM 4640 O O   . HOH G 5 .   ? 5.324   -17.375 23.332  1.00 29.35 ? 305 HOH L O   1 
HETATM 4641 O O   . HOH G 5 .   ? -43.316 -21.188 39.193  1.00 33.20 ? 306 HOH L O   1 
HETATM 4642 O O   . HOH G 5 .   ? -39.880 -12.513 58.039  1.00 42.76 ? 307 HOH L O   1 
HETATM 4643 O O   . HOH G 5 .   ? -18.909 -27.007 52.810  1.00 28.32 ? 308 HOH L O   1 
HETATM 4644 O O   . HOH G 5 .   ? 2.507   -4.393  35.883  1.00 29.29 ? 309 HOH L O   1 
HETATM 4645 O O   . HOH G 5 .   ? -8.031  -14.311 37.495  1.00 30.03 ? 310 HOH L O   1 
HETATM 4646 O O   . HOH G 5 .   ? 4.450   -5.465  34.222  1.00 26.65 ? 311 HOH L O   1 
HETATM 4647 O O   . HOH G 5 .   ? -32.059 -10.989 54.455  1.00 30.63 ? 312 HOH L O   1 
HETATM 4648 O O   . HOH G 5 .   ? -36.601 -31.089 45.075  1.00 54.18 ? 313 HOH L O   1 
HETATM 4649 O O   . HOH G 5 .   ? -36.579 -27.315 53.860  1.00 23.30 ? 314 HOH L O   1 
HETATM 4650 O O   . HOH G 5 .   ? -8.839  -9.639  26.050  1.00 28.17 ? 315 HOH L O   1 
HETATM 4651 O O   . HOH G 5 .   ? -2.108  -9.210  38.443  1.00 31.28 ? 316 HOH L O   1 
HETATM 4652 O O   . HOH G 5 .   ? -2.778  -27.991 44.450  1.00 35.83 ? 317 HOH L O   1 
HETATM 4653 O O   . HOH G 5 .   ? -42.173 -8.448  44.413  1.00 39.65 ? 318 HOH L O   1 
HETATM 4654 O O   . HOH G 5 .   ? -13.247 -13.738 46.191  1.00 37.38 ? 319 HOH L O   1 
HETATM 4655 O O   . HOH G 5 .   ? -6.976  -4.806  21.718  1.00 25.40 ? 320 HOH L O   1 
HETATM 4656 O O   . HOH G 5 .   ? -24.710 -21.158 39.732  1.00 37.99 ? 321 HOH L O   1 
HETATM 4657 O O   . HOH G 5 .   ? -12.140 -24.755 39.565  1.00 41.08 ? 322 HOH L O   1 
HETATM 4658 O O   . HOH G 5 .   ? -8.553  -10.829 34.175  1.00 34.38 ? 323 HOH L O   1 
HETATM 4659 O O   . HOH G 5 .   ? -41.049 -22.872 49.002  1.00 27.57 ? 324 HOH L O   1 
HETATM 4660 O O   . HOH G 5 .   ? -27.701 -8.918  46.997  1.00 29.99 ? 325 HOH L O   1 
HETATM 4661 O O   . HOH G 5 .   ? -45.759 -4.898  45.028  1.00 43.80 ? 326 HOH L O   1 
HETATM 4662 O O   . HOH G 5 .   ? -7.925  -7.370  21.849  1.00 27.56 ? 327 HOH L O   1 
HETATM 4663 O O   . HOH G 5 .   ? 14.595  -15.211 28.570  1.00 33.47 ? 328 HOH L O   1 
HETATM 4664 O O   . HOH G 5 .   ? -10.622 -13.759 38.230  1.00 49.52 ? 329 HOH L O   1 
HETATM 4665 O O   . HOH G 5 .   ? -44.632 -17.926 42.696  1.00 32.64 ? 330 HOH L O   1 
HETATM 4666 O O   . HOH G 5 .   ? -8.214  -5.899  37.994  1.00 39.43 ? 331 HOH L O   1 
HETATM 4667 O O   . HOH G 5 .   ? -8.779  -11.460 17.675  1.00 34.15 ? 332 HOH L O   1 
HETATM 4668 O O   . HOH G 5 .   ? -15.449 -17.454 40.834  1.00 42.95 ? 333 HOH L O   1 
HETATM 4669 O O   . HOH G 5 .   ? -33.561 -14.935 37.835  1.00 43.53 ? 334 HOH L O   1 
HETATM 4670 O O   . HOH G 5 .   ? -43.392 -24.034 39.838  1.00 29.17 ? 335 HOH L O   1 
HETATM 4671 O O   . HOH G 5 .   ? 1.407   -15.193 6.985   1.00 48.00 ? 336 HOH L O   1 
HETATM 4672 O O   . HOH G 5 .   ? -1.856  -4.090  41.318  1.00 35.36 ? 337 HOH L O   1 
HETATM 4673 O O   . HOH G 5 .   ? -40.366 -25.702 49.019  1.00 36.26 ? 338 HOH L O   1 
HETATM 4674 O O   . HOH G 5 .   ? -42.578 -11.436 58.391  1.00 45.37 ? 339 HOH L O   1 
HETATM 4675 O O   . HOH H 5 .   ? -5.155  22.580  -14.094 1.00 48.93 ? 301 HOH C O   1 
HETATM 4676 O O   . HOH H 5 .   ? -10.176 -7.407  5.395   1.00 57.12 ? 302 HOH C O   1 
HETATM 4677 O O   . HOH H 5 .   ? -10.684 -1.109  17.049  1.00 30.00 ? 303 HOH C O   1 
HETATM 4678 O O   . HOH H 5 .   ? -5.347  -2.885  8.892   1.00 19.87 ? 304 HOH C O   1 
HETATM 4679 O O   . HOH H 5 .   ? -5.368  19.386  -11.792 1.00 33.33 ? 305 HOH C O   1 
HETATM 4680 O O   . HOH H 5 .   ? 11.450  17.572  -9.149  1.00 32.39 ? 306 HOH C O   1 
HETATM 4681 O O   . HOH H 5 .   ? 8.442   5.004   12.244  1.00 27.65 ? 307 HOH C O   1 
HETATM 4682 O O   . HOH H 5 .   ? 11.580  12.583  -0.453  1.00 20.97 ? 308 HOH C O   1 
HETATM 4683 O O   . HOH H 5 .   ? -0.364  -3.273  14.489  1.00 24.36 ? 309 HOH C O   1 
HETATM 4684 O O   . HOH H 5 .   ? -7.104  12.637  -0.404  1.00 19.27 ? 310 HOH C O   1 
HETATM 4685 O O   . HOH H 5 .   ? 12.575  9.782   -10.658 1.00 25.30 ? 311 HOH C O   1 
HETATM 4686 O O   . HOH H 5 .   ? -6.927  13.678  18.697  1.00 27.94 ? 312 HOH C O   1 
HETATM 4687 O O   . HOH H 5 .   ? 13.445  17.801  3.035   1.00 28.37 ? 313 HOH C O   1 
HETATM 4688 O O   . HOH H 5 .   ? 1.239   20.270  -8.331  1.00 22.93 ? 314 HOH C O   1 
HETATM 4689 O O   . HOH H 5 .   ? -11.383 5.646   10.858  1.00 29.77 ? 315 HOH C O   1 
HETATM 4690 O O   . HOH H 5 .   ? 9.580   -1.794  0.298   1.00 43.42 ? 316 HOH C O   1 
HETATM 4691 O O   . HOH H 5 .   ? -2.445  11.084  12.187  1.00 24.17 ? 317 HOH C O   1 
HETATM 4692 O O   . HOH H 5 .   ? -9.170  26.377  -0.094  1.00 23.35 ? 318 HOH C O   1 
HETATM 4693 O O   . HOH H 5 .   ? 4.294   0.171   9.672   1.00 20.32 ? 319 HOH C O   1 
HETATM 4694 O O   . HOH H 5 .   ? 4.348   4.096   -9.093  1.00 41.19 ? 320 HOH C O   1 
HETATM 4695 O O   . HOH H 5 .   ? 16.042  20.240  0.685   1.00 21.51 ? 321 HOH C O   1 
HETATM 4696 O O   . HOH H 5 .   ? 3.407   5.843   12.910  1.00 23.65 ? 322 HOH C O   1 
HETATM 4697 O O   . HOH H 5 .   ? 9.727   6.203   10.095  1.00 25.01 ? 323 HOH C O   1 
HETATM 4698 O O   . HOH H 5 .   ? 5.078   6.190   15.113  1.00 23.96 ? 324 HOH C O   1 
HETATM 4699 O O   . HOH H 5 .   ? -10.244 22.920  -7.523  1.00 24.90 ? 325 HOH C O   1 
HETATM 4700 O O   . HOH H 5 .   ? 16.748  4.816   9.130   1.00 35.71 ? 326 HOH C O   1 
HETATM 4701 O O   . HOH H 5 .   ? 17.760  11.998  3.875   1.00 20.68 ? 327 HOH C O   1 
HETATM 4702 O O   . HOH H 5 .   ? -0.503  13.846  11.849  1.00 22.02 ? 328 HOH C O   1 
HETATM 4703 O O   . HOH H 5 .   ? -6.529  21.020  3.759   1.00 19.72 ? 329 HOH C O   1 
HETATM 4704 O O   . HOH H 5 .   ? -14.060 4.337   7.416   1.00 41.88 ? 330 HOH C O   1 
HETATM 4705 O O   . HOH H 5 .   ? 14.139  23.687  6.593   1.00 26.67 ? 331 HOH C O   1 
HETATM 4706 O O   . HOH H 5 .   ? -7.174  16.713  11.105  1.00 24.59 ? 332 HOH C O   1 
HETATM 4707 O O   . HOH H 5 .   ? 2.606   14.329  10.934  1.00 23.60 ? 333 HOH C O   1 
HETATM 4708 O O   . HOH H 5 .   ? 9.033   2.250   9.760   1.00 24.16 ? 334 HOH C O   1 
HETATM 4709 O O   . HOH H 5 .   ? 7.848   -0.063  -5.361  1.00 36.03 ? 335 HOH C O   1 
HETATM 4710 O O   . HOH H 5 .   ? 1.551   2.714   11.126  1.00 21.83 ? 336 HOH C O   1 
HETATM 4711 O O   . HOH H 5 .   ? -6.193  17.841  8.924   1.00 23.94 ? 337 HOH C O   1 
HETATM 4712 O O   . HOH H 5 .   ? 5.735   9.131   -8.109  1.00 23.30 ? 338 HOH C O   1 
HETATM 4713 O O   . HOH H 5 .   ? -4.232  19.526  8.873   1.00 20.32 ? 339 HOH C O   1 
HETATM 4714 O O   . HOH H 5 .   ? -9.101  12.153  15.889  1.00 27.95 ? 340 HOH C O   1 
HETATM 4715 O O   . HOH H 5 .   ? 11.284  3.992   9.051   1.00 29.02 ? 341 HOH C O   1 
HETATM 4716 O O   . HOH H 5 .   ? 10.740  5.251   1.446   1.00 21.71 ? 342 HOH C O   1 
HETATM 4717 O O   . HOH H 5 .   ? -4.587  16.130  7.853   1.00 20.47 ? 343 HOH C O   1 
HETATM 4718 O O   . HOH H 5 .   ? 14.875  4.570   -3.774  1.00 36.38 ? 344 HOH C O   1 
HETATM 4719 O O   . HOH H 5 .   ? 5.055   13.883  9.769   1.00 20.93 ? 345 HOH C O   1 
HETATM 4720 O O   . HOH H 5 .   ? 18.248  10.240  9.244   1.00 31.41 ? 346 HOH C O   1 
HETATM 4721 O O   . HOH H 5 .   ? 9.992   14.655  -10.762 1.00 29.23 ? 347 HOH C O   1 
HETATM 4722 O O   . HOH H 5 .   ? 12.255  5.085   3.542   1.00 28.47 ? 348 HOH C O   1 
HETATM 4723 O O   . HOH H 5 .   ? 14.368  11.488  6.114   1.00 21.50 ? 349 HOH C O   1 
HETATM 4724 O O   . HOH H 5 .   ? -11.816 9.564   10.901  1.00 32.62 ? 350 HOH C O   1 
HETATM 4725 O O   . HOH H 5 .   ? -2.014  11.666  14.645  1.00 21.52 ? 351 HOH C O   1 
HETATM 4726 O O   . HOH H 5 .   ? 1.678   -0.087  9.904   1.00 25.52 ? 352 HOH C O   1 
HETATM 4727 O O   . HOH H 5 .   ? 11.348  16.357  6.210   1.00 31.98 ? 353 HOH C O   1 
HETATM 4728 O O   . HOH H 5 .   ? 6.125   12.377  11.713  1.00 20.96 ? 354 HOH C O   1 
HETATM 4729 O O   . HOH H 5 .   ? -6.218  0.356   8.933   1.00 26.84 ? 355 HOH C O   1 
HETATM 4730 O O   . HOH H 5 .   ? 7.559   -0.296  -2.798  1.00 28.27 ? 356 HOH C O   1 
HETATM 4731 O O   . HOH H 5 .   ? 6.829   -6.559  8.230   1.00 35.32 ? 357 HOH C O   1 
HETATM 4732 O O   . HOH H 5 .   ? 9.356   -5.235  3.098   1.00 36.80 ? 358 HOH C O   1 
HETATM 4733 O O   . HOH H 5 .   ? 14.250  3.719   -6.497  1.00 35.51 ? 359 HOH C O   1 
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