data_9MGY
# 
_entry.id   9MGY 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MGY         pdb_00009mgy 10.2210/pdb9mgy/pdb 
WWPDB D_1000290972 ?            ?                   
EMDB  EMD-48263    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 'Primary map'     1 0 2025-02-26 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MGY 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-11 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of Human NLRP3 complex with compound 1' 
_pdbx_database_related.db_id          EMD-48263 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xiaodi.yu1981@gmail.com 
_pdbx_contact_author.name_first         Xiaodi 
_pdbx_contact_author.name_last          Yu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7520-0646 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mammoliti, O.'    1  ? 
'Carbajo, R.J.'    2  ? 
'Perez-Benito, L.' 3  ? 
'Yu, X.'           4  ? 
'Prieri, M.L.C.'   5  ? 
'Bontempi, L.'     6  ? 
'Embrechts, S.'    7  ? 
'Paesmans, I.'     8  ? 
'Bassi, M.'        9  ? 
'Bhattacharya, A.' 10 ? 
'Roman, S.C.'      11 ? 
'Hoog, S.D.'       12 ? 
'Demin, S.'        13 ? 
'Gijsen, H.J.M.'   14 ? 
'Hache, G.'        15 ? 
'Jacobs, T.'       16 ? 
'Jerhaoui, S.'     17 ? 
'Leenaerts, J.'    18 ? 
'Lutter, F.H.'     19 ? 
'Matico, R.'       20 ? 
'Oehlrich, D.'     21 ? 
'Perrier, M.'      22 ? 
'Ryabchuk, P.'     23 ? 
'Schepens, W.'     24 ? 
'Sharma, S.'       25 ? 
'Somers, M.'       26 ? 
'Suarez, J.'       27 ? 
'Surkyn, M.'       28 ? 
'Opdenbosch, N.V.' 29 ? 
'Verhulst, T.'     30 ? 
'Bottelbergs, A.'  31 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c03108 
_citation.pdbx_database_id_PubMed   39932543 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mammoliti, O.'      1  0000-0002-1521-9254 
primary 'Carbajo, R.'        2  ?                   
primary 'Perez-Benito, L.'   3  ?                   
primary 'Yu, X.'             4  ?                   
primary 'Prieri, M.L.C.'     5  0000-0003-3613-9752 
primary 'Bontempi, L.'       6  ?                   
primary 'Embrechts, S.'      7  ?                   
primary 'Paesmans, I.'       8  ?                   
primary 'Bassi, M.'          9  ?                   
primary 'Bhattacharya, A.'   10 ?                   
primary 'Canellas, S.'       11 0000-0002-8700-4615 
primary 'De Hoog, S.'        12 ?                   
primary 'Demin, S.'          13 0009-0003-8762-5723 
primary 'Gijsen, H.J.M.'     14 0000-0001-8020-4828 
primary 'Hache, G.'          15 ?                   
primary 'Jacobs, T.'         16 ?                   
primary 'Jerhaoui, S.'       17 0009-0007-7642-6509 
primary 'Leenaerts, J.'      18 ?                   
primary 'Lutter, F.H.'       19 ?                   
primary 'Mahieu, M.'         20 ?                   
primary 'Matico, R.'         21 ?                   
primary 'Miller, R.'         22 ?                   
primary 'Oehlrich, D.'       23 0000-0002-3392-1952 
primary 'Perrier, M.'        24 ?                   
primary 'Ryabchuk, P.'       25 0000-0003-2859-3867 
primary 'Schepens, W.'       26 ?                   
primary 'Sharma, S.'         27 ?                   
primary 'Somers, M.'         28 ?                   
primary 'Suarez, J.'         29 ?                   
primary 'Surkyn, M.'         30 ?                   
primary 'Van Opdenbosch, N.' 31 ?                   
primary 'Verhulst, T.'       32 ?                   
primary 'Bottelbergs, A.'    33 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NACHT, LRR and PYD domains-containing protein 3'                                         118323.531 1 3.6.4.- ? 
? ? 
2 non-polymer syn "ADENOSINE-5'-TRIPHOSPHATE"                                                               507.181    1 ?       ? 
? ? 
3 non-polymer syn '(2M)-2-(6-{[(3R)-1-methylpiperidin-3-yl]amino}pyridazin-3-yl)-5-(trifluoromethyl)phenol' 352.354    1 ?       ? 
? ? 
4 water       nat water                                                                                     18.015     7 ?       ? 
? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_entity_poly.pdbx_strand_id                 C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "ADENOSINE-5'-TRIPHOSPHATE"                                                               ATP   
3 '(2M)-2-(6-{[(3R)-1-methylpiperidin-3-yl]amino}pyridazin-3-yl)-5-(trifluoromethyl)phenol' A1BLR 
4 water                                                                                     HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1    MET n 
1 2    LYS n 
1 3    MET n 
1 4    ALA n 
1 5    SER n 
1 6    THR n 
1 7    ARG n 
1 8    CYS n 
1 9    LYS n 
1 10   LEU n 
1 11   ALA n 
1 12   ARG n 
1 13   TYR n 
1 14   LEU n 
1 15   GLU n 
1 16   ASP n 
1 17   LEU n 
1 18   GLU n 
1 19   ASP n 
1 20   VAL n 
1 21   ASP n 
1 22   LEU n 
1 23   LYS n 
1 24   LYS n 
1 25   PHE n 
1 26   LYS n 
1 27   MET n 
1 28   HIS n 
1 29   LEU n 
1 30   GLU n 
1 31   ASP n 
1 32   TYR n 
1 33   PRO n 
1 34   PRO n 
1 35   GLN n 
1 36   LYS n 
1 37   GLY n 
1 38   CYS n 
1 39   ILE n 
1 40   PRO n 
1 41   LEU n 
1 42   PRO n 
1 43   ARG n 
1 44   GLY n 
1 45   GLN n 
1 46   THR n 
1 47   GLU n 
1 48   LYS n 
1 49   ALA n 
1 50   ASP n 
1 51   HIS n 
1 52   VAL n 
1 53   ASP n 
1 54   LEU n 
1 55   ALA n 
1 56   THR n 
1 57   LEU n 
1 58   MET n 
1 59   ILE n 
1 60   ASP n 
1 61   PHE n 
1 62   ASN n 
1 63   GLY n 
1 64   GLU n 
1 65   GLU n 
1 66   LYS n 
1 67   ALA n 
1 68   TRP n 
1 69   ALA n 
1 70   MET n 
1 71   ALA n 
1 72   VAL n 
1 73   TRP n 
1 74   ILE n 
1 75   PHE n 
1 76   ALA n 
1 77   ALA n 
1 78   ILE n 
1 79   ASN n 
1 80   ARG n 
1 81   ARG n 
1 82   ASP n 
1 83   LEU n 
1 84   TYR n 
1 85   GLU n 
1 86   LYS n 
1 87   ALA n 
1 88   LYS n 
1 89   ARG n 
1 90   ASP n 
1 91   GLU n 
1 92   PRO n 
1 93   LYS n 
1 94   TRP n 
1 95   GLY n 
1 96   SER n 
1 97   ASP n 
1 98   ASN n 
1 99   ALA n 
1 100  ARG n 
1 101  VAL n 
1 102  SER n 
1 103  ASN n 
1 104  PRO n 
1 105  THR n 
1 106  VAL n 
1 107  ILE n 
1 108  CYS n 
1 109  GLN n 
1 110  GLU n 
1 111  ASP n 
1 112  SER n 
1 113  ILE n 
1 114  GLU n 
1 115  GLU n 
1 116  GLU n 
1 117  TRP n 
1 118  MET n 
1 119  GLY n 
1 120  LEU n 
1 121  LEU n 
1 122  GLU n 
1 123  TYR n 
1 124  LEU n 
1 125  SER n 
1 126  ARG n 
1 127  ILE n 
1 128  SER n 
1 129  ILE n 
1 130  CYS n 
1 131  LYS n 
1 132  MET n 
1 133  LYS n 
1 134  LYS n 
1 135  ASP n 
1 136  TYR n 
1 137  ARG n 
1 138  LYS n 
1 139  LYS n 
1 140  TYR n 
1 141  ARG n 
1 142  LYS n 
1 143  TYR n 
1 144  VAL n 
1 145  ARG n 
1 146  SER n 
1 147  ARG n 
1 148  PHE n 
1 149  GLN n 
1 150  CYS n 
1 151  ILE n 
1 152  GLU n 
1 153  ASP n 
1 154  ARG n 
1 155  ASN n 
1 156  ALA n 
1 157  ARG n 
1 158  LEU n 
1 159  GLY n 
1 160  GLU n 
1 161  SER n 
1 162  VAL n 
1 163  SER n 
1 164  LEU n 
1 165  ASN n 
1 166  LYS n 
1 167  ARG n 
1 168  TYR n 
1 169  THR n 
1 170  ARG n 
1 171  LEU n 
1 172  ARG n 
1 173  LEU n 
1 174  ILE n 
1 175  LYS n 
1 176  GLU n 
1 177  HIS n 
1 178  ARG n 
1 179  SER n 
1 180  GLN n 
1 181  GLN n 
1 182  GLU n 
1 183  ARG n 
1 184  GLU n 
1 185  GLN n 
1 186  GLU n 
1 187  LEU n 
1 188  LEU n 
1 189  ALA n 
1 190  ILE n 
1 191  GLY n 
1 192  LYS n 
1 193  THR n 
1 194  LYS n 
1 195  THR n 
1 196  CYS n 
1 197  GLU n 
1 198  SER n 
1 199  PRO n 
1 200  VAL n 
1 201  SER n 
1 202  PRO n 
1 203  ILE n 
1 204  LYS n 
1 205  MET n 
1 206  GLU n 
1 207  LEU n 
1 208  LEU n 
1 209  PHE n 
1 210  ASP n 
1 211  PRO n 
1 212  ASP n 
1 213  ASP n 
1 214  GLU n 
1 215  HIS n 
1 216  SER n 
1 217  GLU n 
1 218  PRO n 
1 219  VAL n 
1 220  HIS n 
1 221  THR n 
1 222  VAL n 
1 223  VAL n 
1 224  PHE n 
1 225  GLN n 
1 226  GLY n 
1 227  ALA n 
1 228  ALA n 
1 229  GLY n 
1 230  ILE n 
1 231  GLY n 
1 232  LYS n 
1 233  THR n 
1 234  ILE n 
1 235  LEU n 
1 236  ALA n 
1 237  ARG n 
1 238  LYS n 
1 239  MET n 
1 240  MET n 
1 241  LEU n 
1 242  ASP n 
1 243  TRP n 
1 244  ALA n 
1 245  SER n 
1 246  GLY n 
1 247  THR n 
1 248  LEU n 
1 249  TYR n 
1 250  GLN n 
1 251  ASP n 
1 252  ARG n 
1 253  PHE n 
1 254  ASP n 
1 255  TYR n 
1 256  LEU n 
1 257  PHE n 
1 258  TYR n 
1 259  ILE n 
1 260  HIS n 
1 261  CYS n 
1 262  ARG n 
1 263  GLU n 
1 264  VAL n 
1 265  SER n 
1 266  LEU n 
1 267  VAL n 
1 268  THR n 
1 269  GLN n 
1 270  ARG n 
1 271  SER n 
1 272  LEU n 
1 273  GLY n 
1 274  ASP n 
1 275  LEU n 
1 276  ILE n 
1 277  MET n 
1 278  SER n 
1 279  CYS n 
1 280  CYS n 
1 281  PRO n 
1 282  ASP n 
1 283  PRO n 
1 284  ASN n 
1 285  PRO n 
1 286  PRO n 
1 287  ILE n 
1 288  HIS n 
1 289  LYS n 
1 290  ILE n 
1 291  VAL n 
1 292  ARG n 
1 293  LYS n 
1 294  PRO n 
1 295  SER n 
1 296  ARG n 
1 297  ILE n 
1 298  LEU n 
1 299  PHE n 
1 300  LEU n 
1 301  MET n 
1 302  ASP n 
1 303  GLY n 
1 304  PHE n 
1 305  ASP n 
1 306  GLU n 
1 307  LEU n 
1 308  GLN n 
1 309  GLY n 
1 310  ALA n 
1 311  PHE n 
1 312  ASP n 
1 313  GLU n 
1 314  HIS n 
1 315  ILE n 
1 316  GLY n 
1 317  PRO n 
1 318  LEU n 
1 319  CYS n 
1 320  THR n 
1 321  ASP n 
1 322  TRP n 
1 323  GLN n 
1 324  LYS n 
1 325  ALA n 
1 326  GLU n 
1 327  ARG n 
1 328  GLY n 
1 329  ASP n 
1 330  ILE n 
1 331  LEU n 
1 332  LEU n 
1 333  SER n 
1 334  SER n 
1 335  LEU n 
1 336  ILE n 
1 337  ARG n 
1 338  LYS n 
1 339  LYS n 
1 340  LEU n 
1 341  LEU n 
1 342  PRO n 
1 343  GLU n 
1 344  ALA n 
1 345  SER n 
1 346  LEU n 
1 347  LEU n 
1 348  ILE n 
1 349  THR n 
1 350  THR n 
1 351  ARG n 
1 352  PRO n 
1 353  VAL n 
1 354  ALA n 
1 355  LEU n 
1 356  GLU n 
1 357  LYS n 
1 358  LEU n 
1 359  GLN n 
1 360  HIS n 
1 361  LEU n 
1 362  LEU n 
1 363  ASP n 
1 364  HIS n 
1 365  PRO n 
1 366  ARG n 
1 367  HIS n 
1 368  VAL n 
1 369  GLU n 
1 370  ILE n 
1 371  LEU n 
1 372  GLY n 
1 373  PHE n 
1 374  SER n 
1 375  GLU n 
1 376  ALA n 
1 377  LYS n 
1 378  ARG n 
1 379  LYS n 
1 380  GLU n 
1 381  TYR n 
1 382  PHE n 
1 383  PHE n 
1 384  LYS n 
1 385  TYR n 
1 386  PHE n 
1 387  SER n 
1 388  ASP n 
1 389  GLU n 
1 390  ALA n 
1 391  GLN n 
1 392  ALA n 
1 393  ARG n 
1 394  ALA n 
1 395  ALA n 
1 396  PHE n 
1 397  SER n 
1 398  LEU n 
1 399  ILE n 
1 400  GLN n 
1 401  GLU n 
1 402  ASN n 
1 403  GLU n 
1 404  VAL n 
1 405  LEU n 
1 406  PHE n 
1 407  THR n 
1 408  MET n 
1 409  CYS n 
1 410  PHE n 
1 411  ILE n 
1 412  PRO n 
1 413  LEU n 
1 414  VAL n 
1 415  CYS n 
1 416  TRP n 
1 417  ILE n 
1 418  VAL n 
1 419  CYS n 
1 420  THR n 
1 421  GLY n 
1 422  LEU n 
1 423  LYS n 
1 424  GLN n 
1 425  GLN n 
1 426  MET n 
1 427  GLU n 
1 428  SER n 
1 429  GLY n 
1 430  LYS n 
1 431  SER n 
1 432  LEU n 
1 433  ALA n 
1 434  GLN n 
1 435  THR n 
1 436  SER n 
1 437  LYS n 
1 438  THR n 
1 439  THR n 
1 440  THR n 
1 441  ALA n 
1 442  VAL n 
1 443  TYR n 
1 444  VAL n 
1 445  PHE n 
1 446  PHE n 
1 447  LEU n 
1 448  SER n 
1 449  SER n 
1 450  LEU n 
1 451  LEU n 
1 452  GLN n 
1 453  PRO n 
1 454  ARG n 
1 455  GLY n 
1 456  GLY n 
1 457  SER n 
1 458  GLN n 
1 459  GLU n 
1 460  HIS n 
1 461  GLY n 
1 462  LEU n 
1 463  CYS n 
1 464  ALA n 
1 465  HIS n 
1 466  LEU n 
1 467  TRP n 
1 468  GLY n 
1 469  LEU n 
1 470  CYS n 
1 471  SER n 
1 472  LEU n 
1 473  ALA n 
1 474  ALA n 
1 475  ASP n 
1 476  GLY n 
1 477  ILE n 
1 478  TRP n 
1 479  ASN n 
1 480  GLN n 
1 481  LYS n 
1 482  ILE n 
1 483  LEU n 
1 484  PHE n 
1 485  GLU n 
1 486  GLU n 
1 487  SER n 
1 488  ASP n 
1 489  LEU n 
1 490  ARG n 
1 491  ASN n 
1 492  HIS n 
1 493  GLY n 
1 494  LEU n 
1 495  GLN n 
1 496  LYS n 
1 497  ALA n 
1 498  ASP n 
1 499  VAL n 
1 500  SER n 
1 501  ALA n 
1 502  PHE n 
1 503  LEU n 
1 504  ARG n 
1 505  MET n 
1 506  ASN n 
1 507  LEU n 
1 508  PHE n 
1 509  GLN n 
1 510  LYS n 
1 511  GLU n 
1 512  VAL n 
1 513  ASP n 
1 514  CYS n 
1 515  GLU n 
1 516  LYS n 
1 517  PHE n 
1 518  TYR n 
1 519  SER n 
1 520  PHE n 
1 521  ILE n 
1 522  HIS n 
1 523  MET n 
1 524  THR n 
1 525  PHE n 
1 526  GLN n 
1 527  GLU n 
1 528  PHE n 
1 529  PHE n 
1 530  ALA n 
1 531  ALA n 
1 532  MET n 
1 533  TYR n 
1 534  TYR n 
1 535  LEU n 
1 536  LEU n 
1 537  GLU n 
1 538  GLU n 
1 539  GLU n 
1 540  LYS n 
1 541  GLU n 
1 542  GLY n 
1 543  ARG n 
1 544  THR n 
1 545  ASN n 
1 546  VAL n 
1 547  PRO n 
1 548  GLY n 
1 549  SER n 
1 550  ARG n 
1 551  LEU n 
1 552  LYS n 
1 553  LEU n 
1 554  PRO n 
1 555  SER n 
1 556  ARG n 
1 557  ASP n 
1 558  VAL n 
1 559  THR n 
1 560  VAL n 
1 561  LEU n 
1 562  LEU n 
1 563  GLU n 
1 564  ASN n 
1 565  TYR n 
1 566  GLY n 
1 567  LYS n 
1 568  PHE n 
1 569  GLU n 
1 570  LYS n 
1 571  GLY n 
1 572  TYR n 
1 573  LEU n 
1 574  ILE n 
1 575  PHE n 
1 576  VAL n 
1 577  VAL n 
1 578  ARG n 
1 579  PHE n 
1 580  LEU n 
1 581  PHE n 
1 582  GLY n 
1 583  LEU n 
1 584  VAL n 
1 585  ASN n 
1 586  GLN n 
1 587  GLU n 
1 588  ARG n 
1 589  THR n 
1 590  SER n 
1 591  TYR n 
1 592  LEU n 
1 593  GLU n 
1 594  LYS n 
1 595  LYS n 
1 596  LEU n 
1 597  SER n 
1 598  CYS n 
1 599  LYS n 
1 600  ILE n 
1 601  SER n 
1 602  GLN n 
1 603  GLN n 
1 604  ILE n 
1 605  ARG n 
1 606  LEU n 
1 607  GLU n 
1 608  LEU n 
1 609  LEU n 
1 610  LYS n 
1 611  TRP n 
1 612  ILE n 
1 613  GLU n 
1 614  VAL n 
1 615  LYS n 
1 616  ALA n 
1 617  LYS n 
1 618  ALA n 
1 619  LYS n 
1 620  LYS n 
1 621  LEU n 
1 622  GLN n 
1 623  ILE n 
1 624  GLN n 
1 625  PRO n 
1 626  SER n 
1 627  GLN n 
1 628  LEU n 
1 629  GLU n 
1 630  LEU n 
1 631  PHE n 
1 632  TYR n 
1 633  CYS n 
1 634  LEU n 
1 635  TYR n 
1 636  GLU n 
1 637  MET n 
1 638  GLN n 
1 639  GLU n 
1 640  GLU n 
1 641  ASP n 
1 642  PHE n 
1 643  VAL n 
1 644  GLN n 
1 645  ARG n 
1 646  ALA n 
1 647  MET n 
1 648  ASP n 
1 649  TYR n 
1 650  PHE n 
1 651  PRO n 
1 652  LYS n 
1 653  ILE n 
1 654  GLU n 
1 655  ILE n 
1 656  ASN n 
1 657  LEU n 
1 658  SER n 
1 659  THR n 
1 660  ARG n 
1 661  MET n 
1 662  ASP n 
1 663  HIS n 
1 664  MET n 
1 665  VAL n 
1 666  SER n 
1 667  SER n 
1 668  PHE n 
1 669  CYS n 
1 670  ILE n 
1 671  GLU n 
1 672  ASN n 
1 673  CYS n 
1 674  HIS n 
1 675  ARG n 
1 676  VAL n 
1 677  GLU n 
1 678  SER n 
1 679  LEU n 
1 680  SER n 
1 681  LEU n 
1 682  GLY n 
1 683  PHE n 
1 684  LEU n 
1 685  HIS n 
1 686  ASN n 
1 687  MET n 
1 688  PRO n 
1 689  LYS n 
1 690  GLU n 
1 691  GLU n 
1 692  GLU n 
1 693  GLU n 
1 694  GLU n 
1 695  GLU n 
1 696  LYS n 
1 697  GLU n 
1 698  GLY n 
1 699  ARG n 
1 700  HIS n 
1 701  LEU n 
1 702  ASP n 
1 703  MET n 
1 704  VAL n 
1 705  GLN n 
1 706  CYS n 
1 707  VAL n 
1 708  LEU n 
1 709  PRO n 
1 710  SER n 
1 711  SER n 
1 712  SER n 
1 713  HIS n 
1 714  ALA n 
1 715  ALA n 
1 716  CYS n 
1 717  SER n 
1 718  HIS n 
1 719  GLY n 
1 720  LEU n 
1 721  VAL n 
1 722  ASN n 
1 723  SER n 
1 724  HIS n 
1 725  LEU n 
1 726  THR n 
1 727  SER n 
1 728  SER n 
1 729  PHE n 
1 730  CYS n 
1 731  ARG n 
1 732  GLY n 
1 733  LEU n 
1 734  PHE n 
1 735  SER n 
1 736  VAL n 
1 737  LEU n 
1 738  SER n 
1 739  THR n 
1 740  SER n 
1 741  GLN n 
1 742  SER n 
1 743  LEU n 
1 744  THR n 
1 745  GLU n 
1 746  LEU n 
1 747  ASP n 
1 748  LEU n 
1 749  SER n 
1 750  ASP n 
1 751  ASN n 
1 752  SER n 
1 753  LEU n 
1 754  GLY n 
1 755  ASP n 
1 756  PRO n 
1 757  GLY n 
1 758  MET n 
1 759  ARG n 
1 760  VAL n 
1 761  LEU n 
1 762  CYS n 
1 763  GLU n 
1 764  THR n 
1 765  LEU n 
1 766  GLN n 
1 767  HIS n 
1 768  PRO n 
1 769  GLY n 
1 770  CYS n 
1 771  ASN n 
1 772  ILE n 
1 773  ARG n 
1 774  ARG n 
1 775  LEU n 
1 776  TRP n 
1 777  LEU n 
1 778  GLY n 
1 779  ARG n 
1 780  CYS n 
1 781  GLY n 
1 782  LEU n 
1 783  SER n 
1 784  HIS n 
1 785  GLU n 
1 786  CYS n 
1 787  CYS n 
1 788  PHE n 
1 789  ASP n 
1 790  ILE n 
1 791  SER n 
1 792  LEU n 
1 793  VAL n 
1 794  LEU n 
1 795  SER n 
1 796  SER n 
1 797  ASN n 
1 798  GLN n 
1 799  LYS n 
1 800  LEU n 
1 801  VAL n 
1 802  GLU n 
1 803  LEU n 
1 804  ASP n 
1 805  LEU n 
1 806  SER n 
1 807  ASP n 
1 808  ASN n 
1 809  ALA n 
1 810  LEU n 
1 811  GLY n 
1 812  ASP n 
1 813  PHE n 
1 814  GLY n 
1 815  ILE n 
1 816  ARG n 
1 817  LEU n 
1 818  LEU n 
1 819  CYS n 
1 820  VAL n 
1 821  GLY n 
1 822  LEU n 
1 823  LYS n 
1 824  HIS n 
1 825  LEU n 
1 826  LEU n 
1 827  CYS n 
1 828  ASN n 
1 829  LEU n 
1 830  LYS n 
1 831  LYS n 
1 832  LEU n 
1 833  TRP n 
1 834  LEU n 
1 835  VAL n 
1 836  SER n 
1 837  CYS n 
1 838  CYS n 
1 839  LEU n 
1 840  THR n 
1 841  SER n 
1 842  ALA n 
1 843  CYS n 
1 844  CYS n 
1 845  GLN n 
1 846  ASP n 
1 847  LEU n 
1 848  ALA n 
1 849  SER n 
1 850  VAL n 
1 851  LEU n 
1 852  SER n 
1 853  THR n 
1 854  SER n 
1 855  HIS n 
1 856  SER n 
1 857  LEU n 
1 858  THR n 
1 859  ARG n 
1 860  LEU n 
1 861  TYR n 
1 862  VAL n 
1 863  GLY n 
1 864  GLU n 
1 865  ASN n 
1 866  ALA n 
1 867  LEU n 
1 868  GLY n 
1 869  ASP n 
1 870  SER n 
1 871  GLY n 
1 872  VAL n 
1 873  ALA n 
1 874  ILE n 
1 875  LEU n 
1 876  CYS n 
1 877  GLU n 
1 878  LYS n 
1 879  ALA n 
1 880  LYS n 
1 881  ASN n 
1 882  PRO n 
1 883  GLN n 
1 884  CYS n 
1 885  ASN n 
1 886  LEU n 
1 887  GLN n 
1 888  LYS n 
1 889  LEU n 
1 890  GLY n 
1 891  LEU n 
1 892  VAL n 
1 893  ASN n 
1 894  SER n 
1 895  GLY n 
1 896  LEU n 
1 897  THR n 
1 898  SER n 
1 899  VAL n 
1 900  CYS n 
1 901  CYS n 
1 902  SER n 
1 903  ALA n 
1 904  LEU n 
1 905  SER n 
1 906  SER n 
1 907  VAL n 
1 908  LEU n 
1 909  SER n 
1 910  THR n 
1 911  ASN n 
1 912  GLN n 
1 913  ASN n 
1 914  LEU n 
1 915  THR n 
1 916  HIS n 
1 917  LEU n 
1 918  TYR n 
1 919  LEU n 
1 920  ARG n 
1 921  GLY n 
1 922  ASN n 
1 923  THR n 
1 924  LEU n 
1 925  GLY n 
1 926  ASP n 
1 927  LYS n 
1 928  GLY n 
1 929  ILE n 
1 930  LYS n 
1 931  LEU n 
1 932  LEU n 
1 933  CYS n 
1 934  GLU n 
1 935  GLY n 
1 936  LEU n 
1 937  LEU n 
1 938  HIS n 
1 939  PRO n 
1 940  ASP n 
1 941  CYS n 
1 942  LYS n 
1 943  LEU n 
1 944  GLN n 
1 945  VAL n 
1 946  LEU n 
1 947  GLU n 
1 948  LEU n 
1 949  ASP n 
1 950  ASN n 
1 951  CYS n 
1 952  ASN n 
1 953  LEU n 
1 954  THR n 
1 955  SER n 
1 956  HIS n 
1 957  CYS n 
1 958  CYS n 
1 959  TRP n 
1 960  ASP n 
1 961  LEU n 
1 962  SER n 
1 963  THR n 
1 964  LEU n 
1 965  LEU n 
1 966  THR n 
1 967  SER n 
1 968  SER n 
1 969  GLN n 
1 970  SER n 
1 971  LEU n 
1 972  ARG n 
1 973  LYS n 
1 974  LEU n 
1 975  SER n 
1 976  LEU n 
1 977  GLY n 
1 978  ASN n 
1 979  ASN n 
1 980  ASP n 
1 981  LEU n 
1 982  GLY n 
1 983  ASP n 
1 984  LEU n 
1 985  GLY n 
1 986  VAL n 
1 987  MET n 
1 988  MET n 
1 989  PHE n 
1 990  CYS n 
1 991  GLU n 
1 992  VAL n 
1 993  LEU n 
1 994  LYS n 
1 995  GLN n 
1 996  GLN n 
1 997  SER n 
1 998  CYS n 
1 999  LEU n 
1 1000 LEU n 
1 1001 GLN n 
1 1002 ASN n 
1 1003 LEU n 
1 1004 GLY n 
1 1005 LEU n 
1 1006 SER n 
1 1007 GLU n 
1 1008 MET n 
1 1009 TYR n 
1 1010 PHE n 
1 1011 ASN n 
1 1012 TYR n 
1 1013 GLU n 
1 1014 THR n 
1 1015 LYS n 
1 1016 SER n 
1 1017 ALA n 
1 1018 LEU n 
1 1019 GLU n 
1 1020 THR n 
1 1021 LEU n 
1 1022 GLN n 
1 1023 GLU n 
1 1024 GLU n 
1 1025 LYS n 
1 1026 PRO n 
1 1027 GLU n 
1 1028 LEU n 
1 1029 THR n 
1 1030 VAL n 
1 1031 VAL n 
1 1032 PHE n 
1 1033 GLU n 
1 1034 PRO n 
1 1035 SER n 
1 1036 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   1036 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'NLRP3, C1orf7, CIAS1, NALP3, PYPAF1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BLR non-polymer         . '(2M)-2-(6-{[(3R)-1-methylpiperidin-3-yl]amino}pyridazin-3-yl)-5-(trifluoromethyl)phenol' ? 
'C17 H19 F3 N4 O'   352.354 
ALA   'L-peptide linking' y ALANINE                                                                                   ? 
'C3 H7 N O2'        89.093  
ARG   'L-peptide linking' y ARGININE                                                                                  ? 
'C6 H15 N4 O2 1'    175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                                ? 
'C4 H8 N2 O3'       132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                           ? 
'C4 H7 N O4'        133.103 
ATP   non-polymer         . "ADENOSINE-5'-TRIPHOSPHATE"                                                               ? 
'C10 H16 N5 O13 P3' 507.181 
CYS   'L-peptide linking' y CYSTEINE                                                                                  ? 
'C3 H7 N O2 S'      121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                                 ? 
'C5 H10 N2 O3'      146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                           ? 
'C5 H9 N O4'        147.129 
GLY   'peptide linking'   y GLYCINE                                                                                   ? 
'C2 H5 N O2'        75.067  
HIS   'L-peptide linking' y HISTIDINE                                                                                 ? 
'C6 H10 N3 O2 1'    156.162 
HOH   non-polymer         . WATER                                                                                     ? 'H2 O' 
18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                                                ? 
'C6 H13 N O2'       131.173 
LEU   'L-peptide linking' y LEUCINE                                                                                   ? 
'C6 H13 N O2'       131.173 
LYS   'L-peptide linking' y LYSINE                                                                                    ? 
'C6 H15 N2 O2 1'    147.195 
MET   'L-peptide linking' y METHIONINE                                                                                ? 
'C5 H11 N O2 S'     149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                                             ? 
'C9 H11 N O2'       165.189 
PRO   'L-peptide linking' y PROLINE                                                                                   ? 
'C5 H9 N O2'        115.130 
SER   'L-peptide linking' y SERINE                                                                                    ? 
'C3 H7 N O3'        105.093 
THR   'L-peptide linking' y THREONINE                                                                                 ? 
'C4 H9 N O3'        119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                                ? 
'C11 H12 N2 O2'     204.225 
TYR   'L-peptide linking' y TYROSINE                                                                                  ? 
'C9 H11 N O3'       181.189 
VAL   'L-peptide linking' y VALINE                                                                                    ? 
'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1    MET 1    1    ?    ?   ?   C . n 
A 1 2    LYS 2    2    ?    ?   ?   C . n 
A 1 3    MET 3    3    ?    ?   ?   C . n 
A 1 4    ALA 4    4    ?    ?   ?   C . n 
A 1 5    SER 5    5    ?    ?   ?   C . n 
A 1 6    THR 6    6    ?    ?   ?   C . n 
A 1 7    ARG 7    7    ?    ?   ?   C . n 
A 1 8    CYS 8    8    ?    ?   ?   C . n 
A 1 9    LYS 9    9    ?    ?   ?   C . n 
A 1 10   LEU 10   10   ?    ?   ?   C . n 
A 1 11   ALA 11   11   ?    ?   ?   C . n 
A 1 12   ARG 12   12   ?    ?   ?   C . n 
A 1 13   TYR 13   13   ?    ?   ?   C . n 
A 1 14   LEU 14   14   ?    ?   ?   C . n 
A 1 15   GLU 15   15   ?    ?   ?   C . n 
A 1 16   ASP 16   16   ?    ?   ?   C . n 
A 1 17   LEU 17   17   ?    ?   ?   C . n 
A 1 18   GLU 18   18   ?    ?   ?   C . n 
A 1 19   ASP 19   19   ?    ?   ?   C . n 
A 1 20   VAL 20   20   ?    ?   ?   C . n 
A 1 21   ASP 21   21   ?    ?   ?   C . n 
A 1 22   LEU 22   22   ?    ?   ?   C . n 
A 1 23   LYS 23   23   ?    ?   ?   C . n 
A 1 24   LYS 24   24   ?    ?   ?   C . n 
A 1 25   PHE 25   25   ?    ?   ?   C . n 
A 1 26   LYS 26   26   ?    ?   ?   C . n 
A 1 27   MET 27   27   ?    ?   ?   C . n 
A 1 28   HIS 28   28   ?    ?   ?   C . n 
A 1 29   LEU 29   29   ?    ?   ?   C . n 
A 1 30   GLU 30   30   ?    ?   ?   C . n 
A 1 31   ASP 31   31   ?    ?   ?   C . n 
A 1 32   TYR 32   32   ?    ?   ?   C . n 
A 1 33   PRO 33   33   ?    ?   ?   C . n 
A 1 34   PRO 34   34   ?    ?   ?   C . n 
A 1 35   GLN 35   35   ?    ?   ?   C . n 
A 1 36   LYS 36   36   ?    ?   ?   C . n 
A 1 37   GLY 37   37   ?    ?   ?   C . n 
A 1 38   CYS 38   38   ?    ?   ?   C . n 
A 1 39   ILE 39   39   ?    ?   ?   C . n 
A 1 40   PRO 40   40   ?    ?   ?   C . n 
A 1 41   LEU 41   41   ?    ?   ?   C . n 
A 1 42   PRO 42   42   ?    ?   ?   C . n 
A 1 43   ARG 43   43   ?    ?   ?   C . n 
A 1 44   GLY 44   44   ?    ?   ?   C . n 
A 1 45   GLN 45   45   ?    ?   ?   C . n 
A 1 46   THR 46   46   ?    ?   ?   C . n 
A 1 47   GLU 47   47   ?    ?   ?   C . n 
A 1 48   LYS 48   48   ?    ?   ?   C . n 
A 1 49   ALA 49   49   ?    ?   ?   C . n 
A 1 50   ASP 50   50   ?    ?   ?   C . n 
A 1 51   HIS 51   51   ?    ?   ?   C . n 
A 1 52   VAL 52   52   ?    ?   ?   C . n 
A 1 53   ASP 53   53   ?    ?   ?   C . n 
A 1 54   LEU 54   54   ?    ?   ?   C . n 
A 1 55   ALA 55   55   ?    ?   ?   C . n 
A 1 56   THR 56   56   ?    ?   ?   C . n 
A 1 57   LEU 57   57   ?    ?   ?   C . n 
A 1 58   MET 58   58   ?    ?   ?   C . n 
A 1 59   ILE 59   59   ?    ?   ?   C . n 
A 1 60   ASP 60   60   ?    ?   ?   C . n 
A 1 61   PHE 61   61   ?    ?   ?   C . n 
A 1 62   ASN 62   62   ?    ?   ?   C . n 
A 1 63   GLY 63   63   ?    ?   ?   C . n 
A 1 64   GLU 64   64   ?    ?   ?   C . n 
A 1 65   GLU 65   65   ?    ?   ?   C . n 
A 1 66   LYS 66   66   ?    ?   ?   C . n 
A 1 67   ALA 67   67   ?    ?   ?   C . n 
A 1 68   TRP 68   68   ?    ?   ?   C . n 
A 1 69   ALA 69   69   ?    ?   ?   C . n 
A 1 70   MET 70   70   ?    ?   ?   C . n 
A 1 71   ALA 71   71   ?    ?   ?   C . n 
A 1 72   VAL 72   72   ?    ?   ?   C . n 
A 1 73   TRP 73   73   ?    ?   ?   C . n 
A 1 74   ILE 74   74   ?    ?   ?   C . n 
A 1 75   PHE 75   75   ?    ?   ?   C . n 
A 1 76   ALA 76   76   ?    ?   ?   C . n 
A 1 77   ALA 77   77   ?    ?   ?   C . n 
A 1 78   ILE 78   78   ?    ?   ?   C . n 
A 1 79   ASN 79   79   ?    ?   ?   C . n 
A 1 80   ARG 80   80   ?    ?   ?   C . n 
A 1 81   ARG 81   81   ?    ?   ?   C . n 
A 1 82   ASP 82   82   ?    ?   ?   C . n 
A 1 83   LEU 83   83   ?    ?   ?   C . n 
A 1 84   TYR 84   84   ?    ?   ?   C . n 
A 1 85   GLU 85   85   ?    ?   ?   C . n 
A 1 86   LYS 86   86   ?    ?   ?   C . n 
A 1 87   ALA 87   87   ?    ?   ?   C . n 
A 1 88   LYS 88   88   ?    ?   ?   C . n 
A 1 89   ARG 89   89   ?    ?   ?   C . n 
A 1 90   ASP 90   90   ?    ?   ?   C . n 
A 1 91   GLU 91   91   ?    ?   ?   C . n 
A 1 92   PRO 92   92   ?    ?   ?   C . n 
A 1 93   LYS 93   93   ?    ?   ?   C . n 
A 1 94   TRP 94   94   ?    ?   ?   C . n 
A 1 95   GLY 95   95   ?    ?   ?   C . n 
A 1 96   SER 96   96   ?    ?   ?   C . n 
A 1 97   ASP 97   97   ?    ?   ?   C . n 
A 1 98   ASN 98   98   ?    ?   ?   C . n 
A 1 99   ALA 99   99   ?    ?   ?   C . n 
A 1 100  ARG 100  100  ?    ?   ?   C . n 
A 1 101  VAL 101  101  ?    ?   ?   C . n 
A 1 102  SER 102  102  ?    ?   ?   C . n 
A 1 103  ASN 103  103  ?    ?   ?   C . n 
A 1 104  PRO 104  104  ?    ?   ?   C . n 
A 1 105  THR 105  105  ?    ?   ?   C . n 
A 1 106  VAL 106  106  ?    ?   ?   C . n 
A 1 107  ILE 107  107  ?    ?   ?   C . n 
A 1 108  CYS 108  108  ?    ?   ?   C . n 
A 1 109  GLN 109  109  ?    ?   ?   C . n 
A 1 110  GLU 110  110  ?    ?   ?   C . n 
A 1 111  ASP 111  111  ?    ?   ?   C . n 
A 1 112  SER 112  112  ?    ?   ?   C . n 
A 1 113  ILE 113  113  ?    ?   ?   C . n 
A 1 114  GLU 114  114  ?    ?   ?   C . n 
A 1 115  GLU 115  115  ?    ?   ?   C . n 
A 1 116  GLU 116  116  ?    ?   ?   C . n 
A 1 117  TRP 117  117  ?    ?   ?   C . n 
A 1 118  MET 118  118  ?    ?   ?   C . n 
A 1 119  GLY 119  119  ?    ?   ?   C . n 
A 1 120  LEU 120  120  ?    ?   ?   C . n 
A 1 121  LEU 121  121  ?    ?   ?   C . n 
A 1 122  GLU 122  122  ?    ?   ?   C . n 
A 1 123  TYR 123  123  ?    ?   ?   C . n 
A 1 124  LEU 124  124  ?    ?   ?   C . n 
A 1 125  SER 125  125  ?    ?   ?   C . n 
A 1 126  ARG 126  126  ?    ?   ?   C . n 
A 1 127  ILE 127  127  ?    ?   ?   C . n 
A 1 128  SER 128  128  ?    ?   ?   C . n 
A 1 129  ILE 129  129  ?    ?   ?   C . n 
A 1 130  CYS 130  130  ?    ?   ?   C . n 
A 1 131  LYS 131  131  ?    ?   ?   C . n 
A 1 132  MET 132  132  ?    ?   ?   C . n 
A 1 133  LYS 133  133  133  LYS LYS C . n 
A 1 134  LYS 134  134  134  LYS LYS C . n 
A 1 135  ASP 135  135  135  ASP ASP C . n 
A 1 136  TYR 136  136  136  TYR TYR C . n 
A 1 137  ARG 137  137  137  ARG ARG C . n 
A 1 138  LYS 138  138  138  LYS LYS C . n 
A 1 139  LYS 139  139  139  LYS LYS C . n 
A 1 140  TYR 140  140  140  TYR TYR C . n 
A 1 141  ARG 141  141  141  ARG ARG C . n 
A 1 142  LYS 142  142  142  LYS LYS C . n 
A 1 143  TYR 143  143  143  TYR TYR C . n 
A 1 144  VAL 144  144  144  VAL VAL C . n 
A 1 145  ARG 145  145  145  ARG ARG C . n 
A 1 146  SER 146  146  146  SER SER C . n 
A 1 147  ARG 147  147  147  ARG ARG C . n 
A 1 148  PHE 148  148  148  PHE PHE C . n 
A 1 149  GLN 149  149  149  GLN GLN C . n 
A 1 150  CYS 150  150  150  CYS CYS C . n 
A 1 151  ILE 151  151  151  ILE ILE C . n 
A 1 152  GLU 152  152  152  GLU GLU C . n 
A 1 153  ASP 153  153  153  ASP ASP C . n 
A 1 154  ARG 154  154  154  ARG ARG C . n 
A 1 155  ASN 155  155  155  ASN ASN C . n 
A 1 156  ALA 156  156  156  ALA ALA C . n 
A 1 157  ARG 157  157  157  ARG ARG C . n 
A 1 158  LEU 158  158  158  LEU LEU C . n 
A 1 159  GLY 159  159  159  GLY GLY C . n 
A 1 160  GLU 160  160  160  GLU GLU C . n 
A 1 161  SER 161  161  161  SER SER C . n 
A 1 162  VAL 162  162  162  VAL VAL C . n 
A 1 163  SER 163  163  163  SER SER C . n 
A 1 164  LEU 164  164  164  LEU LEU C . n 
A 1 165  ASN 165  165  165  ASN ASN C . n 
A 1 166  LYS 166  166  166  LYS LYS C . n 
A 1 167  ARG 167  167  167  ARG ARG C . n 
A 1 168  TYR 168  168  168  TYR TYR C . n 
A 1 169  THR 169  169  169  THR THR C . n 
A 1 170  ARG 170  170  170  ARG ARG C . n 
A 1 171  LEU 171  171  171  LEU LEU C . n 
A 1 172  ARG 172  172  172  ARG ARG C . n 
A 1 173  LEU 173  173  173  LEU LEU C . n 
A 1 174  ILE 174  174  174  ILE ILE C . n 
A 1 175  LYS 175  175  175  LYS LYS C . n 
A 1 176  GLU 176  176  176  GLU GLU C . n 
A 1 177  HIS 177  177  ?    ?   ?   C . n 
A 1 178  ARG 178  178  ?    ?   ?   C . n 
A 1 179  SER 179  179  ?    ?   ?   C . n 
A 1 180  GLN 180  180  ?    ?   ?   C . n 
A 1 181  GLN 181  181  ?    ?   ?   C . n 
A 1 182  GLU 182  182  ?    ?   ?   C . n 
A 1 183  ARG 183  183  ?    ?   ?   C . n 
A 1 184  GLU 184  184  ?    ?   ?   C . n 
A 1 185  GLN 185  185  ?    ?   ?   C . n 
A 1 186  GLU 186  186  ?    ?   ?   C . n 
A 1 187  LEU 187  187  ?    ?   ?   C . n 
A 1 188  LEU 188  188  ?    ?   ?   C . n 
A 1 189  ALA 189  189  ?    ?   ?   C . n 
A 1 190  ILE 190  190  ?    ?   ?   C . n 
A 1 191  GLY 191  191  ?    ?   ?   C . n 
A 1 192  LYS 192  192  ?    ?   ?   C . n 
A 1 193  THR 193  193  ?    ?   ?   C . n 
A 1 194  LYS 194  194  ?    ?   ?   C . n 
A 1 195  THR 195  195  ?    ?   ?   C . n 
A 1 196  CYS 196  196  ?    ?   ?   C . n 
A 1 197  GLU 197  197  ?    ?   ?   C . n 
A 1 198  SER 198  198  ?    ?   ?   C . n 
A 1 199  PRO 199  199  ?    ?   ?   C . n 
A 1 200  VAL 200  200  ?    ?   ?   C . n 
A 1 201  SER 201  201  201  SER SER C . n 
A 1 202  PRO 202  202  202  PRO PRO C . n 
A 1 203  ILE 203  203  203  ILE ILE C . n 
A 1 204  LYS 204  204  204  LYS LYS C . n 
A 1 205  MET 205  205  205  MET MET C . n 
A 1 206  GLU 206  206  206  GLU GLU C . n 
A 1 207  LEU 207  207  207  LEU LEU C . n 
A 1 208  LEU 208  208  208  LEU LEU C . n 
A 1 209  PHE 209  209  209  PHE PHE C . n 
A 1 210  ASP 210  210  210  ASP ASP C . n 
A 1 211  PRO 211  211  211  PRO PRO C . n 
A 1 212  ASP 212  212  212  ASP ASP C . n 
A 1 213  ASP 213  213  213  ASP ASP C . n 
A 1 214  GLU 214  214  214  GLU GLU C . n 
A 1 215  HIS 215  215  215  HIS HIS C . n 
A 1 216  SER 216  216  216  SER SER C . n 
A 1 217  GLU 217  217  217  GLU GLU C . n 
A 1 218  PRO 218  218  218  PRO PRO C . n 
A 1 219  VAL 219  219  219  VAL VAL C . n 
A 1 220  HIS 220  220  220  HIS HIS C . n 
A 1 221  THR 221  221  221  THR THR C . n 
A 1 222  VAL 222  222  222  VAL VAL C . n 
A 1 223  VAL 223  223  223  VAL VAL C . n 
A 1 224  PHE 224  224  224  PHE PHE C . n 
A 1 225  GLN 225  225  225  GLN GLN C . n 
A 1 226  GLY 226  226  226  GLY GLY C . n 
A 1 227  ALA 227  227  227  ALA ALA C . n 
A 1 228  ALA 228  228  228  ALA ALA C . n 
A 1 229  GLY 229  229  229  GLY GLY C . n 
A 1 230  ILE 230  230  230  ILE ILE C . n 
A 1 231  GLY 231  231  231  GLY GLY C . n 
A 1 232  LYS 232  232  232  LYS LYS C . n 
A 1 233  THR 233  233  233  THR THR C . n 
A 1 234  ILE 234  234  234  ILE ILE C . n 
A 1 235  LEU 235  235  235  LEU LEU C . n 
A 1 236  ALA 236  236  236  ALA ALA C . n 
A 1 237  ARG 237  237  237  ARG ARG C . n 
A 1 238  LYS 238  238  238  LYS LYS C . n 
A 1 239  MET 239  239  239  MET MET C . n 
A 1 240  MET 240  240  240  MET MET C . n 
A 1 241  LEU 241  241  241  LEU LEU C . n 
A 1 242  ASP 242  242  242  ASP ASP C . n 
A 1 243  TRP 243  243  243  TRP TRP C . n 
A 1 244  ALA 244  244  244  ALA ALA C . n 
A 1 245  SER 245  245  245  SER SER C . n 
A 1 246  GLY 246  246  246  GLY GLY C . n 
A 1 247  THR 247  247  247  THR THR C . n 
A 1 248  LEU 248  248  248  LEU LEU C . n 
A 1 249  TYR 249  249  249  TYR TYR C . n 
A 1 250  GLN 250  250  250  GLN GLN C . n 
A 1 251  ASP 251  251  251  ASP ASP C . n 
A 1 252  ARG 252  252  252  ARG ARG C . n 
A 1 253  PHE 253  253  253  PHE PHE C . n 
A 1 254  ASP 254  254  254  ASP ASP C . n 
A 1 255  TYR 255  255  255  TYR TYR C . n 
A 1 256  LEU 256  256  256  LEU LEU C . n 
A 1 257  PHE 257  257  257  PHE PHE C . n 
A 1 258  TYR 258  258  258  TYR TYR C . n 
A 1 259  ILE 259  259  259  ILE ILE C . n 
A 1 260  HIS 260  260  260  HIS HIS C . n 
A 1 261  CYS 261  261  261  CYS CYS C . n 
A 1 262  ARG 262  262  262  ARG ARG C . n 
A 1 263  GLU 263  263  263  GLU GLU C . n 
A 1 264  VAL 264  264  264  VAL VAL C . n 
A 1 265  SER 265  265  265  SER SER C . n 
A 1 266  LEU 266  266  266  LEU LEU C . n 
A 1 267  VAL 267  267  267  VAL VAL C . n 
A 1 268  THR 268  268  268  THR THR C . n 
A 1 269  GLN 269  269  269  GLN GLN C . n 
A 1 270  ARG 270  270  270  ARG ARG C . n 
A 1 271  SER 271  271  271  SER SER C . n 
A 1 272  LEU 272  272  272  LEU LEU C . n 
A 1 273  GLY 273  273  273  GLY GLY C . n 
A 1 274  ASP 274  274  274  ASP ASP C . n 
A 1 275  LEU 275  275  275  LEU LEU C . n 
A 1 276  ILE 276  276  276  ILE ILE C . n 
A 1 277  MET 277  277  277  MET MET C . n 
A 1 278  SER 278  278  278  SER SER C . n 
A 1 279  CYS 279  279  279  CYS CYS C . n 
A 1 280  CYS 280  280  280  CYS CYS C . n 
A 1 281  PRO 281  281  281  PRO PRO C . n 
A 1 282  ASP 282  282  282  ASP ASP C . n 
A 1 283  PRO 283  283  283  PRO PRO C . n 
A 1 284  ASN 284  284  284  ASN ASN C . n 
A 1 285  PRO 285  285  285  PRO PRO C . n 
A 1 286  PRO 286  286  286  PRO PRO C . n 
A 1 287  ILE 287  287  287  ILE ILE C . n 
A 1 288  HIS 288  288  288  HIS HIS C . n 
A 1 289  LYS 289  289  289  LYS LYS C . n 
A 1 290  ILE 290  290  290  ILE ILE C . n 
A 1 291  VAL 291  291  291  VAL VAL C . n 
A 1 292  ARG 292  292  292  ARG ARG C . n 
A 1 293  LYS 293  293  293  LYS LYS C . n 
A 1 294  PRO 294  294  294  PRO PRO C . n 
A 1 295  SER 295  295  295  SER SER C . n 
A 1 296  ARG 296  296  296  ARG ARG C . n 
A 1 297  ILE 297  297  297  ILE ILE C . n 
A 1 298  LEU 298  298  298  LEU LEU C . n 
A 1 299  PHE 299  299  299  PHE PHE C . n 
A 1 300  LEU 300  300  300  LEU LEU C . n 
A 1 301  MET 301  301  301  MET MET C . n 
A 1 302  ASP 302  302  302  ASP ASP C . n 
A 1 303  GLY 303  303  303  GLY GLY C . n 
A 1 304  PHE 304  304  304  PHE PHE C . n 
A 1 305  ASP 305  305  305  ASP ASP C . n 
A 1 306  GLU 306  306  306  GLU GLU C . n 
A 1 307  LEU 307  307  307  LEU LEU C . n 
A 1 308  GLN 308  308  308  GLN GLN C . n 
A 1 309  GLY 309  309  309  GLY GLY C . n 
A 1 310  ALA 310  310  310  ALA ALA C . n 
A 1 311  PHE 311  311  311  PHE PHE C . n 
A 1 312  ASP 312  312  312  ASP ASP C . n 
A 1 313  GLU 313  313  313  GLU GLU C . n 
A 1 314  HIS 314  314  314  HIS HIS C . n 
A 1 315  ILE 315  315  315  ILE ILE C . n 
A 1 316  GLY 316  316  316  GLY GLY C . n 
A 1 317  PRO 317  317  317  PRO PRO C . n 
A 1 318  LEU 318  318  318  LEU LEU C . n 
A 1 319  CYS 319  319  319  CYS CYS C . n 
A 1 320  THR 320  320  320  THR THR C . n 
A 1 321  ASP 321  321  321  ASP ASP C . n 
A 1 322  TRP 322  322  322  TRP TRP C . n 
A 1 323  GLN 323  323  323  GLN GLN C . n 
A 1 324  LYS 324  324  324  LYS LYS C . n 
A 1 325  ALA 325  325  325  ALA ALA C . n 
A 1 326  GLU 326  326  326  GLU GLU C . n 
A 1 327  ARG 327  327  327  ARG ARG C . n 
A 1 328  GLY 328  328  328  GLY GLY C . n 
A 1 329  ASP 329  329  329  ASP ASP C . n 
A 1 330  ILE 330  330  330  ILE ILE C . n 
A 1 331  LEU 331  331  331  LEU LEU C . n 
A 1 332  LEU 332  332  332  LEU LEU C . n 
A 1 333  SER 333  333  333  SER SER C . n 
A 1 334  SER 334  334  334  SER SER C . n 
A 1 335  LEU 335  335  335  LEU LEU C . n 
A 1 336  ILE 336  336  336  ILE ILE C . n 
A 1 337  ARG 337  337  337  ARG ARG C . n 
A 1 338  LYS 338  338  338  LYS LYS C . n 
A 1 339  LYS 339  339  339  LYS LYS C . n 
A 1 340  LEU 340  340  340  LEU LEU C . n 
A 1 341  LEU 341  341  341  LEU LEU C . n 
A 1 342  PRO 342  342  342  PRO PRO C . n 
A 1 343  GLU 343  343  343  GLU GLU C . n 
A 1 344  ALA 344  344  344  ALA ALA C . n 
A 1 345  SER 345  345  345  SER SER C . n 
A 1 346  LEU 346  346  346  LEU LEU C . n 
A 1 347  LEU 347  347  347  LEU LEU C . n 
A 1 348  ILE 348  348  348  ILE ILE C . n 
A 1 349  THR 349  349  349  THR THR C . n 
A 1 350  THR 350  350  350  THR THR C . n 
A 1 351  ARG 351  351  351  ARG ARG C . n 
A 1 352  PRO 352  352  352  PRO PRO C . n 
A 1 353  VAL 353  353  353  VAL VAL C . n 
A 1 354  ALA 354  354  354  ALA ALA C . n 
A 1 355  LEU 355  355  355  LEU LEU C . n 
A 1 356  GLU 356  356  356  GLU GLU C . n 
A 1 357  LYS 357  357  357  LYS LYS C . n 
A 1 358  LEU 358  358  358  LEU LEU C . n 
A 1 359  GLN 359  359  359  GLN GLN C . n 
A 1 360  HIS 360  360  360  HIS HIS C . n 
A 1 361  LEU 361  361  361  LEU LEU C . n 
A 1 362  LEU 362  362  362  LEU LEU C . n 
A 1 363  ASP 363  363  363  ASP ASP C . n 
A 1 364  HIS 364  364  364  HIS HIS C . n 
A 1 365  PRO 365  365  365  PRO PRO C . n 
A 1 366  ARG 366  366  366  ARG ARG C . n 
A 1 367  HIS 367  367  367  HIS HIS C . n 
A 1 368  VAL 368  368  368  VAL VAL C . n 
A 1 369  GLU 369  369  369  GLU GLU C . n 
A 1 370  ILE 370  370  370  ILE ILE C . n 
A 1 371  LEU 371  371  371  LEU LEU C . n 
A 1 372  GLY 372  372  372  GLY GLY C . n 
A 1 373  PHE 373  373  373  PHE PHE C . n 
A 1 374  SER 374  374  374  SER SER C . n 
A 1 375  GLU 375  375  375  GLU GLU C . n 
A 1 376  ALA 376  376  376  ALA ALA C . n 
A 1 377  LYS 377  377  377  LYS LYS C . n 
A 1 378  ARG 378  378  378  ARG ARG C . n 
A 1 379  LYS 379  379  379  LYS LYS C . n 
A 1 380  GLU 380  380  380  GLU GLU C . n 
A 1 381  TYR 381  381  381  TYR TYR C . n 
A 1 382  PHE 382  382  382  PHE PHE C . n 
A 1 383  PHE 383  383  383  PHE PHE C . n 
A 1 384  LYS 384  384  384  LYS LYS C . n 
A 1 385  TYR 385  385  385  TYR TYR C . n 
A 1 386  PHE 386  386  386  PHE PHE C . n 
A 1 387  SER 387  387  387  SER SER C . n 
A 1 388  ASP 388  388  388  ASP ASP C . n 
A 1 389  GLU 389  389  389  GLU GLU C . n 
A 1 390  ALA 390  390  390  ALA ALA C . n 
A 1 391  GLN 391  391  391  GLN GLN C . n 
A 1 392  ALA 392  392  392  ALA ALA C . n 
A 1 393  ARG 393  393  393  ARG ARG C . n 
A 1 394  ALA 394  394  394  ALA ALA C . n 
A 1 395  ALA 395  395  395  ALA ALA C . n 
A 1 396  PHE 396  396  396  PHE PHE C . n 
A 1 397  SER 397  397  397  SER SER C . n 
A 1 398  LEU 398  398  398  LEU LEU C . n 
A 1 399  ILE 399  399  399  ILE ILE C . n 
A 1 400  GLN 400  400  400  GLN GLN C . n 
A 1 401  GLU 401  401  401  GLU GLU C . n 
A 1 402  ASN 402  402  402  ASN ASN C . n 
A 1 403  GLU 403  403  403  GLU GLU C . n 
A 1 404  VAL 404  404  404  VAL VAL C . n 
A 1 405  LEU 405  405  405  LEU LEU C . n 
A 1 406  PHE 406  406  406  PHE PHE C . n 
A 1 407  THR 407  407  407  THR THR C . n 
A 1 408  MET 408  408  408  MET MET C . n 
A 1 409  CYS 409  409  409  CYS CYS C . n 
A 1 410  PHE 410  410  410  PHE PHE C . n 
A 1 411  ILE 411  411  411  ILE ILE C . n 
A 1 412  PRO 412  412  412  PRO PRO C . n 
A 1 413  LEU 413  413  413  LEU LEU C . n 
A 1 414  VAL 414  414  414  VAL VAL C . n 
A 1 415  CYS 415  415  415  CYS CYS C . n 
A 1 416  TRP 416  416  416  TRP TRP C . n 
A 1 417  ILE 417  417  417  ILE ILE C . n 
A 1 418  VAL 418  418  418  VAL VAL C . n 
A 1 419  CYS 419  419  419  CYS CYS C . n 
A 1 420  THR 420  420  420  THR THR C . n 
A 1 421  GLY 421  421  421  GLY GLY C . n 
A 1 422  LEU 422  422  422  LEU LEU C . n 
A 1 423  LYS 423  423  423  LYS LYS C . n 
A 1 424  GLN 424  424  424  GLN GLN C . n 
A 1 425  GLN 425  425  425  GLN GLN C . n 
A 1 426  MET 426  426  426  MET MET C . n 
A 1 427  GLU 427  427  427  GLU GLU C . n 
A 1 428  SER 428  428  428  SER SER C . n 
A 1 429  GLY 429  429  429  GLY GLY C . n 
A 1 430  LYS 430  430  430  LYS LYS C . n 
A 1 431  SER 431  431  431  SER SER C . n 
A 1 432  LEU 432  432  432  LEU LEU C . n 
A 1 433  ALA 433  433  433  ALA ALA C . n 
A 1 434  GLN 434  434  434  GLN GLN C . n 
A 1 435  THR 435  435  435  THR THR C . n 
A 1 436  SER 436  436  436  SER SER C . n 
A 1 437  LYS 437  437  437  LYS LYS C . n 
A 1 438  THR 438  438  438  THR THR C . n 
A 1 439  THR 439  439  439  THR THR C . n 
A 1 440  THR 440  440  440  THR THR C . n 
A 1 441  ALA 441  441  441  ALA ALA C . n 
A 1 442  VAL 442  442  442  VAL VAL C . n 
A 1 443  TYR 443  443  443  TYR TYR C . n 
A 1 444  VAL 444  444  444  VAL VAL C . n 
A 1 445  PHE 445  445  445  PHE PHE C . n 
A 1 446  PHE 446  446  446  PHE PHE C . n 
A 1 447  LEU 447  447  447  LEU LEU C . n 
A 1 448  SER 448  448  448  SER SER C . n 
A 1 449  SER 449  449  449  SER SER C . n 
A 1 450  LEU 450  450  450  LEU LEU C . n 
A 1 451  LEU 451  451  451  LEU LEU C . n 
A 1 452  GLN 452  452  452  GLN GLN C . n 
A 1 453  PRO 453  453  453  PRO PRO C . n 
A 1 454  ARG 454  454  ?    ?   ?   C . n 
A 1 455  GLY 455  455  ?    ?   ?   C . n 
A 1 456  GLY 456  456  ?    ?   ?   C . n 
A 1 457  SER 457  457  ?    ?   ?   C . n 
A 1 458  GLN 458  458  ?    ?   ?   C . n 
A 1 459  GLU 459  459  ?    ?   ?   C . n 
A 1 460  HIS 460  460  ?    ?   ?   C . n 
A 1 461  GLY 461  461  ?    ?   ?   C . n 
A 1 462  LEU 462  462  462  LEU LEU C . n 
A 1 463  CYS 463  463  463  CYS CYS C . n 
A 1 464  ALA 464  464  464  ALA ALA C . n 
A 1 465  HIS 465  465  465  HIS HIS C . n 
A 1 466  LEU 466  466  466  LEU LEU C . n 
A 1 467  TRP 467  467  467  TRP TRP C . n 
A 1 468  GLY 468  468  468  GLY GLY C . n 
A 1 469  LEU 469  469  469  LEU LEU C . n 
A 1 470  CYS 470  470  470  CYS CYS C . n 
A 1 471  SER 471  471  471  SER SER C . n 
A 1 472  LEU 472  472  472  LEU LEU C . n 
A 1 473  ALA 473  473  473  ALA ALA C . n 
A 1 474  ALA 474  474  474  ALA ALA C . n 
A 1 475  ASP 475  475  475  ASP ASP C . n 
A 1 476  GLY 476  476  476  GLY GLY C . n 
A 1 477  ILE 477  477  477  ILE ILE C . n 
A 1 478  TRP 478  478  478  TRP TRP C . n 
A 1 479  ASN 479  479  479  ASN ASN C . n 
A 1 480  GLN 480  480  480  GLN GLN C . n 
A 1 481  LYS 481  481  481  LYS LYS C . n 
A 1 482  ILE 482  482  482  ILE ILE C . n 
A 1 483  LEU 483  483  483  LEU LEU C . n 
A 1 484  PHE 484  484  484  PHE PHE C . n 
A 1 485  GLU 485  485  485  GLU GLU C . n 
A 1 486  GLU 486  486  486  GLU GLU C . n 
A 1 487  SER 487  487  487  SER SER C . n 
A 1 488  ASP 488  488  488  ASP ASP C . n 
A 1 489  LEU 489  489  489  LEU LEU C . n 
A 1 490  ARG 490  490  490  ARG ARG C . n 
A 1 491  ASN 491  491  491  ASN ASN C . n 
A 1 492  HIS 492  492  492  HIS HIS C . n 
A 1 493  GLY 493  493  493  GLY GLY C . n 
A 1 494  LEU 494  494  494  LEU LEU C . n 
A 1 495  GLN 495  495  495  GLN GLN C . n 
A 1 496  LYS 496  496  496  LYS LYS C . n 
A 1 497  ALA 497  497  497  ALA ALA C . n 
A 1 498  ASP 498  498  498  ASP ASP C . n 
A 1 499  VAL 499  499  499  VAL VAL C . n 
A 1 500  SER 500  500  500  SER SER C . n 
A 1 501  ALA 501  501  501  ALA ALA C . n 
A 1 502  PHE 502  502  502  PHE PHE C . n 
A 1 503  LEU 503  503  503  LEU LEU C . n 
A 1 504  ARG 504  504  504  ARG ARG C . n 
A 1 505  MET 505  505  505  MET MET C . n 
A 1 506  ASN 506  506  506  ASN ASN C . n 
A 1 507  LEU 507  507  507  LEU LEU C . n 
A 1 508  PHE 508  508  508  PHE PHE C . n 
A 1 509  GLN 509  509  509  GLN GLN C . n 
A 1 510  LYS 510  510  510  LYS LYS C . n 
A 1 511  GLU 511  511  511  GLU GLU C . n 
A 1 512  VAL 512  512  512  VAL VAL C . n 
A 1 513  ASP 513  513  513  ASP ASP C . n 
A 1 514  CYS 514  514  514  CYS CYS C . n 
A 1 515  GLU 515  515  515  GLU GLU C . n 
A 1 516  LYS 516  516  516  LYS LYS C . n 
A 1 517  PHE 517  517  517  PHE PHE C . n 
A 1 518  TYR 518  518  518  TYR TYR C . n 
A 1 519  SER 519  519  519  SER SER C . n 
A 1 520  PHE 520  520  520  PHE PHE C . n 
A 1 521  ILE 521  521  521  ILE ILE C . n 
A 1 522  HIS 522  522  522  HIS HIS C . n 
A 1 523  MET 523  523  523  MET MET C . n 
A 1 524  THR 524  524  524  THR THR C . n 
A 1 525  PHE 525  525  525  PHE PHE C . n 
A 1 526  GLN 526  526  526  GLN GLN C . n 
A 1 527  GLU 527  527  527  GLU GLU C . n 
A 1 528  PHE 528  528  528  PHE PHE C . n 
A 1 529  PHE 529  529  529  PHE PHE C . n 
A 1 530  ALA 530  530  530  ALA ALA C . n 
A 1 531  ALA 531  531  531  ALA ALA C . n 
A 1 532  MET 532  532  532  MET MET C . n 
A 1 533  TYR 533  533  533  TYR TYR C . n 
A 1 534  TYR 534  534  534  TYR TYR C . n 
A 1 535  LEU 535  535  535  LEU LEU C . n 
A 1 536  LEU 536  536  536  LEU LEU C . n 
A 1 537  GLU 537  537  537  GLU GLU C . n 
A 1 538  GLU 538  538  ?    ?   ?   C . n 
A 1 539  GLU 539  539  ?    ?   ?   C . n 
A 1 540  LYS 540  540  ?    ?   ?   C . n 
A 1 541  GLU 541  541  ?    ?   ?   C . n 
A 1 542  GLY 542  542  ?    ?   ?   C . n 
A 1 543  ARG 543  543  ?    ?   ?   C . n 
A 1 544  THR 544  544  ?    ?   ?   C . n 
A 1 545  ASN 545  545  ?    ?   ?   C . n 
A 1 546  VAL 546  546  ?    ?   ?   C . n 
A 1 547  PRO 547  547  ?    ?   ?   C . n 
A 1 548  GLY 548  548  ?    ?   ?   C . n 
A 1 549  SER 549  549  ?    ?   ?   C . n 
A 1 550  ARG 550  550  ?    ?   ?   C . n 
A 1 551  LEU 551  551  ?    ?   ?   C . n 
A 1 552  LYS 552  552  ?    ?   ?   C . n 
A 1 553  LEU 553  553  553  LEU LEU C . n 
A 1 554  PRO 554  554  554  PRO PRO C . n 
A 1 555  SER 555  555  555  SER SER C . n 
A 1 556  ARG 556  556  556  ARG ARG C . n 
A 1 557  ASP 557  557  557  ASP ASP C . n 
A 1 558  VAL 558  558  558  VAL VAL C . n 
A 1 559  THR 559  559  559  THR THR C . n 
A 1 560  VAL 560  560  560  VAL VAL C . n 
A 1 561  LEU 561  561  561  LEU LEU C . n 
A 1 562  LEU 562  562  562  LEU LEU C . n 
A 1 563  GLU 563  563  563  GLU GLU C . n 
A 1 564  ASN 564  564  564  ASN ASN C . n 
A 1 565  TYR 565  565  565  TYR TYR C . n 
A 1 566  GLY 566  566  566  GLY GLY C . n 
A 1 567  LYS 567  567  567  LYS LYS C . n 
A 1 568  PHE 568  568  568  PHE PHE C . n 
A 1 569  GLU 569  569  569  GLU GLU C . n 
A 1 570  LYS 570  570  570  LYS LYS C . n 
A 1 571  GLY 571  571  571  GLY GLY C . n 
A 1 572  TYR 572  572  572  TYR TYR C . n 
A 1 573  LEU 573  573  573  LEU LEU C . n 
A 1 574  ILE 574  574  574  ILE ILE C . n 
A 1 575  PHE 575  575  575  PHE PHE C . n 
A 1 576  VAL 576  576  576  VAL VAL C . n 
A 1 577  VAL 577  577  577  VAL VAL C . n 
A 1 578  ARG 578  578  578  ARG ARG C . n 
A 1 579  PHE 579  579  579  PHE PHE C . n 
A 1 580  LEU 580  580  580  LEU LEU C . n 
A 1 581  PHE 581  581  581  PHE PHE C . n 
A 1 582  GLY 582  582  582  GLY GLY C . n 
A 1 583  LEU 583  583  583  LEU LEU C . n 
A 1 584  VAL 584  584  584  VAL VAL C . n 
A 1 585  ASN 585  585  585  ASN ASN C . n 
A 1 586  GLN 586  586  586  GLN GLN C . n 
A 1 587  GLU 587  587  587  GLU GLU C . n 
A 1 588  ARG 588  588  588  ARG ARG C . n 
A 1 589  THR 589  589  589  THR THR C . n 
A 1 590  SER 590  590  590  SER SER C . n 
A 1 591  TYR 591  591  591  TYR TYR C . n 
A 1 592  LEU 592  592  592  LEU LEU C . n 
A 1 593  GLU 593  593  593  GLU GLU C . n 
A 1 594  LYS 594  594  594  LYS LYS C . n 
A 1 595  LYS 595  595  595  LYS LYS C . n 
A 1 596  LEU 596  596  596  LEU LEU C . n 
A 1 597  SER 597  597  597  SER SER C . n 
A 1 598  CYS 598  598  598  CYS CYS C . n 
A 1 599  LYS 599  599  599  LYS LYS C . n 
A 1 600  ILE 600  600  600  ILE ILE C . n 
A 1 601  SER 601  601  601  SER SER C . n 
A 1 602  GLN 602  602  602  GLN GLN C . n 
A 1 603  GLN 603  603  603  GLN GLN C . n 
A 1 604  ILE 604  604  604  ILE ILE C . n 
A 1 605  ARG 605  605  605  ARG ARG C . n 
A 1 606  LEU 606  606  606  LEU LEU C . n 
A 1 607  GLU 607  607  607  GLU GLU C . n 
A 1 608  LEU 608  608  608  LEU LEU C . n 
A 1 609  LEU 609  609  609  LEU LEU C . n 
A 1 610  LYS 610  610  610  LYS LYS C . n 
A 1 611  TRP 611  611  611  TRP TRP C . n 
A 1 612  ILE 612  612  612  ILE ILE C . n 
A 1 613  GLU 613  613  613  GLU GLU C . n 
A 1 614  VAL 614  614  614  VAL VAL C . n 
A 1 615  LYS 615  615  615  LYS LYS C . n 
A 1 616  ALA 616  616  616  ALA ALA C . n 
A 1 617  LYS 617  617  617  LYS LYS C . n 
A 1 618  ALA 618  618  618  ALA ALA C . n 
A 1 619  LYS 619  619  619  LYS LYS C . n 
A 1 620  LYS 620  620  620  LYS LYS C . n 
A 1 621  LEU 621  621  621  LEU LEU C . n 
A 1 622  GLN 622  622  622  GLN GLN C . n 
A 1 623  ILE 623  623  623  ILE ILE C . n 
A 1 624  GLN 624  624  624  GLN GLN C . n 
A 1 625  PRO 625  625  625  PRO PRO C . n 
A 1 626  SER 626  626  626  SER SER C . n 
A 1 627  GLN 627  627  627  GLN GLN C . n 
A 1 628  LEU 628  628  628  LEU LEU C . n 
A 1 629  GLU 629  629  629  GLU GLU C . n 
A 1 630  LEU 630  630  630  LEU LEU C . n 
A 1 631  PHE 631  631  631  PHE PHE C . n 
A 1 632  TYR 632  632  632  TYR TYR C . n 
A 1 633  CYS 633  633  633  CYS CYS C . n 
A 1 634  LEU 634  634  634  LEU LEU C . n 
A 1 635  TYR 635  635  635  TYR TYR C . n 
A 1 636  GLU 636  636  636  GLU GLU C . n 
A 1 637  MET 637  637  637  MET MET C . n 
A 1 638  GLN 638  638  638  GLN GLN C . n 
A 1 639  GLU 639  639  639  GLU GLU C . n 
A 1 640  GLU 640  640  640  GLU GLU C . n 
A 1 641  ASP 641  641  641  ASP ASP C . n 
A 1 642  PHE 642  642  642  PHE PHE C . n 
A 1 643  VAL 643  643  643  VAL VAL C . n 
A 1 644  GLN 644  644  644  GLN GLN C . n 
A 1 645  ARG 645  645  645  ARG ARG C . n 
A 1 646  ALA 646  646  646  ALA ALA C . n 
A 1 647  MET 647  647  647  MET MET C . n 
A 1 648  ASP 648  648  648  ASP ASP C . n 
A 1 649  TYR 649  649  649  TYR TYR C . n 
A 1 650  PHE 650  650  650  PHE PHE C . n 
A 1 651  PRO 651  651  651  PRO PRO C . n 
A 1 652  LYS 652  652  652  LYS LYS C . n 
A 1 653  ILE 653  653  653  ILE ILE C . n 
A 1 654  GLU 654  654  654  GLU GLU C . n 
A 1 655  ILE 655  655  655  ILE ILE C . n 
A 1 656  ASN 656  656  656  ASN ASN C . n 
A 1 657  LEU 657  657  657  LEU LEU C . n 
A 1 658  SER 658  658  658  SER SER C . n 
A 1 659  THR 659  659  659  THR THR C . n 
A 1 660  ARG 660  660  660  ARG ARG C . n 
A 1 661  MET 661  661  661  MET MET C . n 
A 1 662  ASP 662  662  662  ASP ASP C . n 
A 1 663  HIS 663  663  663  HIS HIS C . n 
A 1 664  MET 664  664  664  MET MET C . n 
A 1 665  VAL 665  665  665  VAL VAL C . n 
A 1 666  SER 666  666  666  SER SER C . n 
A 1 667  SER 667  667  667  SER SER C . n 
A 1 668  PHE 668  668  668  PHE PHE C . n 
A 1 669  CYS 669  669  669  CYS CYS C . n 
A 1 670  ILE 670  670  670  ILE ILE C . n 
A 1 671  GLU 671  671  671  GLU GLU C . n 
A 1 672  ASN 672  672  672  ASN ASN C . n 
A 1 673  CYS 673  673  673  CYS CYS C . n 
A 1 674  HIS 674  674  674  HIS HIS C . n 
A 1 675  ARG 675  675  675  ARG ARG C . n 
A 1 676  VAL 676  676  676  VAL VAL C . n 
A 1 677  GLU 677  677  677  GLU GLU C . n 
A 1 678  SER 678  678  678  SER SER C . n 
A 1 679  LEU 679  679  679  LEU LEU C . n 
A 1 680  SER 680  680  680  SER SER C . n 
A 1 681  LEU 681  681  681  LEU LEU C . n 
A 1 682  GLY 682  682  682  GLY GLY C . n 
A 1 683  PHE 683  683  683  PHE PHE C . n 
A 1 684  LEU 684  684  684  LEU LEU C . n 
A 1 685  HIS 685  685  685  HIS HIS C . n 
A 1 686  ASN 686  686  686  ASN ASN C . n 
A 1 687  MET 687  687  ?    ?   ?   C . n 
A 1 688  PRO 688  688  ?    ?   ?   C . n 
A 1 689  LYS 689  689  ?    ?   ?   C . n 
A 1 690  GLU 690  690  ?    ?   ?   C . n 
A 1 691  GLU 691  691  ?    ?   ?   C . n 
A 1 692  GLU 692  692  ?    ?   ?   C . n 
A 1 693  GLU 693  693  ?    ?   ?   C . n 
A 1 694  GLU 694  694  ?    ?   ?   C . n 
A 1 695  GLU 695  695  ?    ?   ?   C . n 
A 1 696  LYS 696  696  ?    ?   ?   C . n 
A 1 697  GLU 697  697  ?    ?   ?   C . n 
A 1 698  GLY 698  698  ?    ?   ?   C . n 
A 1 699  ARG 699  699  ?    ?   ?   C . n 
A 1 700  HIS 700  700  ?    ?   ?   C . n 
A 1 701  LEU 701  701  ?    ?   ?   C . n 
A 1 702  ASP 702  702  ?    ?   ?   C . n 
A 1 703  MET 703  703  ?    ?   ?   C . n 
A 1 704  VAL 704  704  ?    ?   ?   C . n 
A 1 705  GLN 705  705  ?    ?   ?   C . n 
A 1 706  CYS 706  706  ?    ?   ?   C . n 
A 1 707  VAL 707  707  ?    ?   ?   C . n 
A 1 708  LEU 708  708  ?    ?   ?   C . n 
A 1 709  PRO 709  709  ?    ?   ?   C . n 
A 1 710  SER 710  710  ?    ?   ?   C . n 
A 1 711  SER 711  711  ?    ?   ?   C . n 
A 1 712  SER 712  712  ?    ?   ?   C . n 
A 1 713  HIS 713  713  ?    ?   ?   C . n 
A 1 714  ALA 714  714  ?    ?   ?   C . n 
A 1 715  ALA 715  715  ?    ?   ?   C . n 
A 1 716  CYS 716  716  ?    ?   ?   C . n 
A 1 717  SER 717  717  ?    ?   ?   C . n 
A 1 718  HIS 718  718  ?    ?   ?   C . n 
A 1 719  GLY 719  719  ?    ?   ?   C . n 
A 1 720  LEU 720  720  ?    ?   ?   C . n 
A 1 721  VAL 721  721  ?    ?   ?   C . n 
A 1 722  ASN 722  722  ?    ?   ?   C . n 
A 1 723  SER 723  723  ?    ?   ?   C . n 
A 1 724  HIS 724  724  ?    ?   ?   C . n 
A 1 725  LEU 725  725  725  LEU LEU C . n 
A 1 726  THR 726  726  726  THR THR C . n 
A 1 727  SER 727  727  727  SER SER C . n 
A 1 728  SER 728  728  728  SER SER C . n 
A 1 729  PHE 729  729  729  PHE PHE C . n 
A 1 730  CYS 730  730  730  CYS CYS C . n 
A 1 731  ARG 731  731  731  ARG ARG C . n 
A 1 732  GLY 732  732  732  GLY GLY C . n 
A 1 733  LEU 733  733  733  LEU LEU C . n 
A 1 734  PHE 734  734  734  PHE PHE C . n 
A 1 735  SER 735  735  735  SER SER C . n 
A 1 736  VAL 736  736  736  VAL VAL C . n 
A 1 737  LEU 737  737  737  LEU LEU C . n 
A 1 738  SER 738  738  738  SER SER C . n 
A 1 739  THR 739  739  739  THR THR C . n 
A 1 740  SER 740  740  740  SER SER C . n 
A 1 741  GLN 741  741  741  GLN GLN C . n 
A 1 742  SER 742  742  742  SER SER C . n 
A 1 743  LEU 743  743  743  LEU LEU C . n 
A 1 744  THR 744  744  744  THR THR C . n 
A 1 745  GLU 745  745  745  GLU GLU C . n 
A 1 746  LEU 746  746  746  LEU LEU C . n 
A 1 747  ASP 747  747  747  ASP ASP C . n 
A 1 748  LEU 748  748  748  LEU LEU C . n 
A 1 749  SER 749  749  749  SER SER C . n 
A 1 750  ASP 750  750  750  ASP ASP C . n 
A 1 751  ASN 751  751  751  ASN ASN C . n 
A 1 752  SER 752  752  752  SER SER C . n 
A 1 753  LEU 753  753  753  LEU LEU C . n 
A 1 754  GLY 754  754  754  GLY GLY C . n 
A 1 755  ASP 755  755  755  ASP ASP C . n 
A 1 756  PRO 756  756  756  PRO PRO C . n 
A 1 757  GLY 757  757  757  GLY GLY C . n 
A 1 758  MET 758  758  758  MET MET C . n 
A 1 759  ARG 759  759  759  ARG ARG C . n 
A 1 760  VAL 760  760  760  VAL VAL C . n 
A 1 761  LEU 761  761  761  LEU LEU C . n 
A 1 762  CYS 762  762  762  CYS CYS C . n 
A 1 763  GLU 763  763  763  GLU GLU C . n 
A 1 764  THR 764  764  764  THR THR C . n 
A 1 765  LEU 765  765  765  LEU LEU C . n 
A 1 766  GLN 766  766  766  GLN GLN C . n 
A 1 767  HIS 767  767  767  HIS HIS C . n 
A 1 768  PRO 768  768  768  PRO PRO C . n 
A 1 769  GLY 769  769  769  GLY GLY C . n 
A 1 770  CYS 770  770  770  CYS CYS C . n 
A 1 771  ASN 771  771  771  ASN ASN C . n 
A 1 772  ILE 772  772  772  ILE ILE C . n 
A 1 773  ARG 773  773  773  ARG ARG C . n 
A 1 774  ARG 774  774  774  ARG ARG C . n 
A 1 775  LEU 775  775  775  LEU LEU C . n 
A 1 776  TRP 776  776  776  TRP TRP C . n 
A 1 777  LEU 777  777  777  LEU LEU C . n 
A 1 778  GLY 778  778  778  GLY GLY C . n 
A 1 779  ARG 779  779  779  ARG ARG C . n 
A 1 780  CYS 780  780  780  CYS CYS C . n 
A 1 781  GLY 781  781  781  GLY GLY C . n 
A 1 782  LEU 782  782  782  LEU LEU C . n 
A 1 783  SER 783  783  783  SER SER C . n 
A 1 784  HIS 784  784  784  HIS HIS C . n 
A 1 785  GLU 785  785  785  GLU GLU C . n 
A 1 786  CYS 786  786  786  CYS CYS C . n 
A 1 787  CYS 787  787  787  CYS CYS C . n 
A 1 788  PHE 788  788  788  PHE PHE C . n 
A 1 789  ASP 789  789  789  ASP ASP C . n 
A 1 790  ILE 790  790  790  ILE ILE C . n 
A 1 791  SER 791  791  791  SER SER C . n 
A 1 792  LEU 792  792  792  LEU LEU C . n 
A 1 793  VAL 793  793  793  VAL VAL C . n 
A 1 794  LEU 794  794  794  LEU LEU C . n 
A 1 795  SER 795  795  795  SER SER C . n 
A 1 796  SER 796  796  796  SER SER C . n 
A 1 797  ASN 797  797  797  ASN ASN C . n 
A 1 798  GLN 798  798  798  GLN GLN C . n 
A 1 799  LYS 799  799  799  LYS LYS C . n 
A 1 800  LEU 800  800  800  LEU LEU C . n 
A 1 801  VAL 801  801  801  VAL VAL C . n 
A 1 802  GLU 802  802  802  GLU GLU C . n 
A 1 803  LEU 803  803  803  LEU LEU C . n 
A 1 804  ASP 804  804  804  ASP ASP C . n 
A 1 805  LEU 805  805  805  LEU LEU C . n 
A 1 806  SER 806  806  806  SER SER C . n 
A 1 807  ASP 807  807  807  ASP ASP C . n 
A 1 808  ASN 808  808  808  ASN ASN C . n 
A 1 809  ALA 809  809  809  ALA ALA C . n 
A 1 810  LEU 810  810  810  LEU LEU C . n 
A 1 811  GLY 811  811  811  GLY GLY C . n 
A 1 812  ASP 812  812  812  ASP ASP C . n 
A 1 813  PHE 813  813  813  PHE PHE C . n 
A 1 814  GLY 814  814  814  GLY GLY C . n 
A 1 815  ILE 815  815  815  ILE ILE C . n 
A 1 816  ARG 816  816  816  ARG ARG C . n 
A 1 817  LEU 817  817  817  LEU LEU C . n 
A 1 818  LEU 818  818  818  LEU LEU C . n 
A 1 819  CYS 819  819  819  CYS CYS C . n 
A 1 820  VAL 820  820  820  VAL VAL C . n 
A 1 821  GLY 821  821  821  GLY GLY C . n 
A 1 822  LEU 822  822  822  LEU LEU C . n 
A 1 823  LYS 823  823  823  LYS LYS C . n 
A 1 824  HIS 824  824  824  HIS HIS C . n 
A 1 825  LEU 825  825  825  LEU LEU C . n 
A 1 826  LEU 826  826  826  LEU LEU C . n 
A 1 827  CYS 827  827  827  CYS CYS C . n 
A 1 828  ASN 828  828  828  ASN ASN C . n 
A 1 829  LEU 829  829  829  LEU LEU C . n 
A 1 830  LYS 830  830  830  LYS LYS C . n 
A 1 831  LYS 831  831  831  LYS LYS C . n 
A 1 832  LEU 832  832  832  LEU LEU C . n 
A 1 833  TRP 833  833  833  TRP TRP C . n 
A 1 834  LEU 834  834  834  LEU LEU C . n 
A 1 835  VAL 835  835  835  VAL VAL C . n 
A 1 836  SER 836  836  836  SER SER C . n 
A 1 837  CYS 837  837  837  CYS CYS C . n 
A 1 838  CYS 838  838  838  CYS CYS C . n 
A 1 839  LEU 839  839  839  LEU LEU C . n 
A 1 840  THR 840  840  840  THR THR C . n 
A 1 841  SER 841  841  841  SER SER C . n 
A 1 842  ALA 842  842  842  ALA ALA C . n 
A 1 843  CYS 843  843  843  CYS CYS C . n 
A 1 844  CYS 844  844  844  CYS CYS C . n 
A 1 845  GLN 845  845  845  GLN GLN C . n 
A 1 846  ASP 846  846  846  ASP ASP C . n 
A 1 847  LEU 847  847  847  LEU LEU C . n 
A 1 848  ALA 848  848  848  ALA ALA C . n 
A 1 849  SER 849  849  849  SER SER C . n 
A 1 850  VAL 850  850  850  VAL VAL C . n 
A 1 851  LEU 851  851  851  LEU LEU C . n 
A 1 852  SER 852  852  852  SER SER C . n 
A 1 853  THR 853  853  853  THR THR C . n 
A 1 854  SER 854  854  854  SER SER C . n 
A 1 855  HIS 855  855  855  HIS HIS C . n 
A 1 856  SER 856  856  856  SER SER C . n 
A 1 857  LEU 857  857  857  LEU LEU C . n 
A 1 858  THR 858  858  858  THR THR C . n 
A 1 859  ARG 859  859  859  ARG ARG C . n 
A 1 860  LEU 860  860  860  LEU LEU C . n 
A 1 861  TYR 861  861  861  TYR TYR C . n 
A 1 862  VAL 862  862  862  VAL VAL C . n 
A 1 863  GLY 863  863  863  GLY GLY C . n 
A 1 864  GLU 864  864  864  GLU GLU C . n 
A 1 865  ASN 865  865  865  ASN ASN C . n 
A 1 866  ALA 866  866  866  ALA ALA C . n 
A 1 867  LEU 867  867  867  LEU LEU C . n 
A 1 868  GLY 868  868  868  GLY GLY C . n 
A 1 869  ASP 869  869  869  ASP ASP C . n 
A 1 870  SER 870  870  870  SER SER C . n 
A 1 871  GLY 871  871  871  GLY GLY C . n 
A 1 872  VAL 872  872  872  VAL VAL C . n 
A 1 873  ALA 873  873  873  ALA ALA C . n 
A 1 874  ILE 874  874  874  ILE ILE C . n 
A 1 875  LEU 875  875  875  LEU LEU C . n 
A 1 876  CYS 876  876  876  CYS CYS C . n 
A 1 877  GLU 877  877  877  GLU GLU C . n 
A 1 878  LYS 878  878  878  LYS LYS C . n 
A 1 879  ALA 879  879  879  ALA ALA C . n 
A 1 880  LYS 880  880  880  LYS LYS C . n 
A 1 881  ASN 881  881  881  ASN ASN C . n 
A 1 882  PRO 882  882  882  PRO PRO C . n 
A 1 883  GLN 883  883  883  GLN GLN C . n 
A 1 884  CYS 884  884  884  CYS CYS C . n 
A 1 885  ASN 885  885  885  ASN ASN C . n 
A 1 886  LEU 886  886  886  LEU LEU C . n 
A 1 887  GLN 887  887  887  GLN GLN C . n 
A 1 888  LYS 888  888  888  LYS LYS C . n 
A 1 889  LEU 889  889  889  LEU LEU C . n 
A 1 890  GLY 890  890  890  GLY GLY C . n 
A 1 891  LEU 891  891  891  LEU LEU C . n 
A 1 892  VAL 892  892  892  VAL VAL C . n 
A 1 893  ASN 893  893  893  ASN ASN C . n 
A 1 894  SER 894  894  894  SER SER C . n 
A 1 895  GLY 895  895  895  GLY GLY C . n 
A 1 896  LEU 896  896  896  LEU LEU C . n 
A 1 897  THR 897  897  897  THR THR C . n 
A 1 898  SER 898  898  898  SER SER C . n 
A 1 899  VAL 899  899  899  VAL VAL C . n 
A 1 900  CYS 900  900  900  CYS CYS C . n 
A 1 901  CYS 901  901  901  CYS CYS C . n 
A 1 902  SER 902  902  902  SER SER C . n 
A 1 903  ALA 903  903  903  ALA ALA C . n 
A 1 904  LEU 904  904  904  LEU LEU C . n 
A 1 905  SER 905  905  905  SER SER C . n 
A 1 906  SER 906  906  906  SER SER C . n 
A 1 907  VAL 907  907  907  VAL VAL C . n 
A 1 908  LEU 908  908  908  LEU LEU C . n 
A 1 909  SER 909  909  909  SER SER C . n 
A 1 910  THR 910  910  910  THR THR C . n 
A 1 911  ASN 911  911  911  ASN ASN C . n 
A 1 912  GLN 912  912  912  GLN GLN C . n 
A 1 913  ASN 913  913  913  ASN ASN C . n 
A 1 914  LEU 914  914  914  LEU LEU C . n 
A 1 915  THR 915  915  915  THR THR C . n 
A 1 916  HIS 916  916  916  HIS HIS C . n 
A 1 917  LEU 917  917  917  LEU LEU C . n 
A 1 918  TYR 918  918  918  TYR TYR C . n 
A 1 919  LEU 919  919  919  LEU LEU C . n 
A 1 920  ARG 920  920  920  ARG ARG C . n 
A 1 921  GLY 921  921  921  GLY GLY C . n 
A 1 922  ASN 922  922  922  ASN ASN C . n 
A 1 923  THR 923  923  923  THR THR C . n 
A 1 924  LEU 924  924  924  LEU LEU C . n 
A 1 925  GLY 925  925  925  GLY GLY C . n 
A 1 926  ASP 926  926  926  ASP ASP C . n 
A 1 927  LYS 927  927  927  LYS LYS C . n 
A 1 928  GLY 928  928  928  GLY GLY C . n 
A 1 929  ILE 929  929  929  ILE ILE C . n 
A 1 930  LYS 930  930  930  LYS LYS C . n 
A 1 931  LEU 931  931  931  LEU LEU C . n 
A 1 932  LEU 932  932  932  LEU LEU C . n 
A 1 933  CYS 933  933  933  CYS CYS C . n 
A 1 934  GLU 934  934  934  GLU GLU C . n 
A 1 935  GLY 935  935  935  GLY GLY C . n 
A 1 936  LEU 936  936  936  LEU LEU C . n 
A 1 937  LEU 937  937  937  LEU LEU C . n 
A 1 938  HIS 938  938  938  HIS HIS C . n 
A 1 939  PRO 939  939  939  PRO PRO C . n 
A 1 940  ASP 940  940  940  ASP ASP C . n 
A 1 941  CYS 941  941  941  CYS CYS C . n 
A 1 942  LYS 942  942  942  LYS LYS C . n 
A 1 943  LEU 943  943  943  LEU LEU C . n 
A 1 944  GLN 944  944  944  GLN GLN C . n 
A 1 945  VAL 945  945  945  VAL VAL C . n 
A 1 946  LEU 946  946  946  LEU LEU C . n 
A 1 947  GLU 947  947  947  GLU GLU C . n 
A 1 948  LEU 948  948  948  LEU LEU C . n 
A 1 949  ASP 949  949  949  ASP ASP C . n 
A 1 950  ASN 950  950  950  ASN ASN C . n 
A 1 951  CYS 951  951  951  CYS CYS C . n 
A 1 952  ASN 952  952  952  ASN ASN C . n 
A 1 953  LEU 953  953  953  LEU LEU C . n 
A 1 954  THR 954  954  954  THR THR C . n 
A 1 955  SER 955  955  955  SER SER C . n 
A 1 956  HIS 956  956  956  HIS HIS C . n 
A 1 957  CYS 957  957  957  CYS CYS C . n 
A 1 958  CYS 958  958  958  CYS CYS C . n 
A 1 959  TRP 959  959  959  TRP TRP C . n 
A 1 960  ASP 960  960  960  ASP ASP C . n 
A 1 961  LEU 961  961  961  LEU LEU C . n 
A 1 962  SER 962  962  962  SER SER C . n 
A 1 963  THR 963  963  963  THR THR C . n 
A 1 964  LEU 964  964  964  LEU LEU C . n 
A 1 965  LEU 965  965  965  LEU LEU C . n 
A 1 966  THR 966  966  966  THR THR C . n 
A 1 967  SER 967  967  967  SER SER C . n 
A 1 968  SER 968  968  968  SER SER C . n 
A 1 969  GLN 969  969  969  GLN GLN C . n 
A 1 970  SER 970  970  970  SER SER C . n 
A 1 971  LEU 971  971  971  LEU LEU C . n 
A 1 972  ARG 972  972  972  ARG ARG C . n 
A 1 973  LYS 973  973  973  LYS LYS C . n 
A 1 974  LEU 974  974  974  LEU LEU C . n 
A 1 975  SER 975  975  975  SER SER C . n 
A 1 976  LEU 976  976  976  LEU LEU C . n 
A 1 977  GLY 977  977  977  GLY GLY C . n 
A 1 978  ASN 978  978  978  ASN ASN C . n 
A 1 979  ASN 979  979  979  ASN ASN C . n 
A 1 980  ASP 980  980  980  ASP ASP C . n 
A 1 981  LEU 981  981  981  LEU LEU C . n 
A 1 982  GLY 982  982  982  GLY GLY C . n 
A 1 983  ASP 983  983  983  ASP ASP C . n 
A 1 984  LEU 984  984  984  LEU LEU C . n 
A 1 985  GLY 985  985  985  GLY GLY C . n 
A 1 986  VAL 986  986  986  VAL VAL C . n 
A 1 987  MET 987  987  987  MET MET C . n 
A 1 988  MET 988  988  988  MET MET C . n 
A 1 989  PHE 989  989  989  PHE PHE C . n 
A 1 990  CYS 990  990  990  CYS CYS C . n 
A 1 991  GLU 991  991  991  GLU GLU C . n 
A 1 992  VAL 992  992  992  VAL VAL C . n 
A 1 993  LEU 993  993  993  LEU LEU C . n 
A 1 994  LYS 994  994  994  LYS LYS C . n 
A 1 995  GLN 995  995  995  GLN GLN C . n 
A 1 996  GLN 996  996  996  GLN GLN C . n 
A 1 997  SER 997  997  997  SER SER C . n 
A 1 998  CYS 998  998  998  CYS CYS C . n 
A 1 999  LEU 999  999  999  LEU LEU C . n 
A 1 1000 LEU 1000 1000 1000 LEU LEU C . n 
A 1 1001 GLN 1001 1001 1001 GLN GLN C . n 
A 1 1002 ASN 1002 1002 1002 ASN ASN C . n 
A 1 1003 LEU 1003 1003 1003 LEU LEU C . n 
A 1 1004 GLY 1004 1004 1004 GLY GLY C . n 
A 1 1005 LEU 1005 1005 1005 LEU LEU C . n 
A 1 1006 SER 1006 1006 1006 SER SER C . n 
A 1 1007 GLU 1007 1007 1007 GLU GLU C . n 
A 1 1008 MET 1008 1008 1008 MET MET C . n 
A 1 1009 TYR 1009 1009 1009 TYR TYR C . n 
A 1 1010 PHE 1010 1010 1010 PHE PHE C . n 
A 1 1011 ASN 1011 1011 1011 ASN ASN C . n 
A 1 1012 TYR 1012 1012 1012 TYR TYR C . n 
A 1 1013 GLU 1013 1013 1013 GLU GLU C . n 
A 1 1014 THR 1014 1014 1014 THR THR C . n 
A 1 1015 LYS 1015 1015 1015 LYS LYS C . n 
A 1 1016 SER 1016 1016 1016 SER SER C . n 
A 1 1017 ALA 1017 1017 1017 ALA ALA C . n 
A 1 1018 LEU 1018 1018 1018 LEU LEU C . n 
A 1 1019 GLU 1019 1019 1019 GLU GLU C . n 
A 1 1020 THR 1020 1020 1020 THR THR C . n 
A 1 1021 LEU 1021 1021 1021 LEU LEU C . n 
A 1 1022 GLN 1022 1022 1022 GLN GLN C . n 
A 1 1023 GLU 1023 1023 1023 GLU GLU C . n 
A 1 1024 GLU 1024 1024 1024 GLU GLU C . n 
A 1 1025 LYS 1025 1025 1025 LYS LYS C . n 
A 1 1026 PRO 1026 1026 1026 PRO PRO C . n 
A 1 1027 GLU 1027 1027 1027 GLU GLU C . n 
A 1 1028 LEU 1028 1028 1028 LEU LEU C . n 
A 1 1029 THR 1029 1029 1029 THR THR C . n 
A 1 1030 VAL 1030 1030 1030 VAL VAL C . n 
A 1 1031 VAL 1031 1031 1031 VAL VAL C . n 
A 1 1032 PHE 1032 1032 1032 PHE PHE C . n 
A 1 1033 GLU 1033 1033 1033 GLU GLU C . n 
A 1 1034 PRO 1034 1034 1034 PRO PRO C . n 
A 1 1035 SER 1035 1035 1035 SER SER C . n 
A 1 1036 TRP 1036 1036 ?    ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BLR 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BLR 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ATP   1 1101 1102 ATP   ATP C . 
C 3 A1BLR 1 1102 1103 A1BLR LIG C . 
D 4 HOH   1 1201 6    HOH   HOH C . 
D 4 HOH   2 1202 3    HOH   HOH C . 
D 4 HOH   3 1203 2    HOH   HOH C . 
D 4 HOH   4 1204 5    HOH   HOH C . 
D 4 HOH   5 1205 1    HOH   HOH C . 
D 4 HOH   6 1206 7    HOH   HOH C . 
D 4 HOH   7 1207 4    HOH   HOH C . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MGY 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MGY 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MGY 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9MGY 
_struct.title                        'Cryo-EM structure of Human NLRP3 complex with compound 1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MGY 
_struct_keywords.text            'NLRP3, cryo-EM, small molecule inhibitor, inflammasome, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NLRP3_HUMAN 
_struct_ref.pdbx_db_accession          Q96P20 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINR
RDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGE
SVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCT
DWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQ
ENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV
LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE
DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL
VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK
NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9MGY 
_struct_ref_seq.pdbx_strand_id                C 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 1036 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q96P20 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1036 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       1036 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TYR A 136  ? PHE A 148  ? TYR C 136  PHE C 148  1 ? 13 
HELX_P HELX_P2  AA2 LEU A 164  ? TYR A 168  ? LEU C 164  TYR C 168  5 ? 5  
HELX_P HELX_P3  AA3 GLY A 231  ? SER A 245  ? GLY C 231  SER C 245  1 ? 15 
HELX_P HELX_P4  AA4 GLY A 273  ? SER A 278  ? GLY C 273  SER C 278  1 ? 6  
HELX_P HELX_P5  AA5 LYS A 289  ? LYS A 293  ? LYS C 289  LYS C 293  5 ? 5  
HELX_P HELX_P6  AA6 PHE A 304  ? LEU A 307  ? PHE C 304  LEU C 307  5 ? 4  
HELX_P HELX_P7  AA7 GLY A 328  ? ARG A 337  ? GLY C 328  ARG C 337  1 ? 10 
HELX_P HELX_P8  AA8 ARG A 351  ? VAL A 353  ? ARG C 351  VAL C 353  5 ? 3  
HELX_P HELX_P9  AA9 ALA A 354  ? ASP A 363  ? ALA C 354  ASP C 363  1 ? 10 
HELX_P HELX_P10 AB1 SER A 374  ? PHE A 386  ? SER C 374  PHE C 386  1 ? 13 
HELX_P HELX_P11 AB2 ASP A 388  ? GLU A 401  ? ASP C 388  GLU C 401  1 ? 14 
HELX_P HELX_P12 AB3 ASN A 402  ? CYS A 409  ? ASN C 402  CYS C 409  1 ? 8  
HELX_P HELX_P13 AB4 ILE A 411  ? SER A 428  ? ILE C 411  SER C 428  1 ? 18 
HELX_P HELX_P14 AB5 THR A 438  ? GLN A 452  ? THR C 438  GLN C 452  1 ? 15 
HELX_P HELX_P15 AB6 LEU A 462  ? ALA A 464  ? LEU C 462  ALA C 464  5 ? 3  
HELX_P HELX_P16 AB7 HIS A 465  ? ASN A 479  ? HIS C 465  ASN C 479  1 ? 15 
HELX_P HELX_P17 AB8 GLU A 485  ? ASN A 491  ? GLU C 485  ASN C 491  1 ? 7  
HELX_P HELX_P18 AB9 LYS A 496  ? MET A 505  ? LYS C 496  MET C 505  1 ? 10 
HELX_P HELX_P19 AC1 HIS A 522  ? TYR A 534  ? HIS C 522  TYR C 534  1 ? 13 
HELX_P HELX_P20 AC2 ASP A 557  ? ASN A 564  ? ASP C 557  ASN C 564  1 ? 8  
HELX_P HELX_P21 AC3 LYS A 567  ? GLY A 571  ? LYS C 567  GLY C 571  5 ? 5  
HELX_P HELX_P22 AC4 LEU A 573  ? VAL A 584  ? LEU C 573  VAL C 584  1 ? 12 
HELX_P HELX_P23 AC5 LEU A 592  ? LEU A 596  ? LEU C 592  LEU C 596  5 ? 5  
HELX_P HELX_P24 AC6 SER A 597  ? ALA A 616  ? SER C 597  ALA C 616  1 ? 20 
HELX_P HELX_P25 AC7 GLN A 627  ? GLU A 636  ? GLN C 627  GLU C 636  1 ? 10 
HELX_P HELX_P26 AC8 GLU A 639  ? MET A 647  ? GLU C 639  MET C 647  1 ? 9  
HELX_P HELX_P27 AC9 ASP A 648  ? PHE A 650  ? ASP C 648  PHE C 650  5 ? 3  
HELX_P HELX_P28 AD1 THR A 659  ? ASN A 672  ? THR C 659  ASN C 672  1 ? 14 
HELX_P HELX_P29 AD2 CYS A 730  ? SER A 738  ? CYS C 730  SER C 738  1 ? 9  
HELX_P HELX_P30 AD3 GLY A 754  ? GLN A 766  ? GLY C 754  GLN C 766  1 ? 13 
HELX_P HELX_P31 AD4 GLU A 785  ? SER A 795  ? GLU C 785  SER C 795  1 ? 11 
HELX_P HELX_P32 AD5 GLY A 811  ? LYS A 823  ? GLY C 811  LYS C 823  1 ? 13 
HELX_P HELX_P33 AD6 THR A 840  ? ALA A 842  ? THR C 840  ALA C 842  5 ? 3  
HELX_P HELX_P34 AD7 CYS A 843  ? SER A 854  ? CYS C 843  SER C 854  1 ? 12 
HELX_P HELX_P35 AD8 GLY A 868  ? LYS A 880  ? GLY C 868  LYS C 880  1 ? 13 
HELX_P HELX_P36 AD9 THR A 897  ? VAL A 899  ? THR C 897  VAL C 899  5 ? 3  
HELX_P HELX_P37 AE1 CYS A 900  ? ASN A 911  ? CYS C 900  ASN C 911  1 ? 12 
HELX_P HELX_P38 AE2 LEU A 924  ? LEU A 937  ? LEU C 924  LEU C 937  1 ? 14 
HELX_P HELX_P39 AE3 THR A 954  ? HIS A 956  ? THR C 954  HIS C 956  5 ? 3  
HELX_P HELX_P40 AE4 CYS A 957  ? THR A 966  ? CYS C 957  THR C 966  1 ? 10 
HELX_P HELX_P41 AE5 GLY A 982  ? LEU A 993  ? GLY C 982  LEU C 993  1 ? 12 
HELX_P HELX_P42 AE6 ASN A 1011 ? LYS A 1025 ? ASN C 1011 LYS C 1025 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6  ? 
AA2 ? 2  ? 
AA3 ? 2  ? 
AA4 ? 11 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 2  3  ? parallel      
AA1 3  4  ? parallel      
AA1 4  5  ? parallel      
AA1 5  6  ? parallel      
AA2 1  2  ? anti-parallel 
AA3 1  2  ? anti-parallel 
AA4 1  2  ? parallel      
AA4 2  3  ? parallel      
AA4 3  4  ? parallel      
AA4 4  5  ? parallel      
AA4 5  6  ? parallel      
AA4 6  7  ? parallel      
AA4 7  8  ? parallel      
AA4 8  9  ? parallel      
AA4 9  10 ? parallel      
AA4 10 11 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ARG A 172 ? LYS A 175 ? ARG C 172 LYS C 175 
AA1 2  ARG A 366 ? LEU A 371 ? ARG C 366 LEU C 371 
AA1 3  THR A 221 ? GLN A 225 ? THR C 221 GLN C 225 
AA1 4  SER A 345 ? THR A 350 ? SER C 345 THR C 350 
AA1 5  ILE A 297 ? ASP A 302 ? ILE C 297 ASP C 302 
AA1 6  TYR A 255 ? HIS A 260 ? TYR C 255 HIS C 260 
AA2 1  GLN A 269 ? ARG A 270 ? GLN C 269 ARG C 270 
AA2 2  GLU A 326 ? ARG A 327 ? GLU C 326 ARG C 327 
AA3 1  PHE A 508 ? GLN A 509 ? PHE C 508 GLN C 509 
AA3 2  SER A 519 ? PHE A 520 ? SER C 519 PHE C 520 
AA4 1  LYS A 652 ? LEU A 657 ? LYS C 652 LEU C 657 
AA4 2  SER A 678 ? PHE A 683 ? SER C 678 PHE C 683 
AA4 3  GLU A 745 ? ASP A 747 ? GLU C 745 ASP C 747 
AA4 4  ARG A 774 ? TRP A 776 ? ARG C 774 TRP C 776 
AA4 5  GLU A 802 ? ASP A 804 ? GLU C 802 ASP C 804 
AA4 6  LYS A 831 ? TRP A 833 ? LYS C 831 TRP C 833 
AA4 7  ARG A 859 ? TYR A 861 ? ARG C 859 TYR C 861 
AA4 8  LYS A 888 ? GLY A 890 ? LYS C 888 GLY C 890 
AA4 9  HIS A 916 ? TYR A 918 ? HIS C 916 TYR C 918 
AA4 10 VAL A 945 ? LEU A 948 ? VAL C 945 LEU C 948 
AA4 11 LYS A 973 ? LEU A 976 ? LYS C 973 LEU C 976 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N ARG A 172 ? N ARG C 172 O LEU A 371 ? O LEU C 371 
AA1 2  3  O ARG A 366 ? O ARG C 366 N VAL A 223 ? N VAL C 223 
AA1 3  4  N PHE A 224 ? N PHE C 224 O ILE A 348 ? O ILE C 348 
AA1 4  5  O LEU A 347 ? O LEU C 347 N MET A 301 ? N MET C 301 
AA1 5  6  O LEU A 300 ? O LEU C 300 N ILE A 259 ? N ILE C 259 
AA2 1  2  N ARG A 270 ? N ARG C 270 O GLU A 326 ? O GLU C 326 
AA3 1  2  N GLN A 509 ? N GLN C 509 O SER A 519 ? O SER C 519 
AA4 1  2  N ILE A 653 ? N ILE C 653 O SER A 680 ? O SER C 680 
AA4 2  3  N LEU A 679 ? N LEU C 679 O ASP A 747 ? O ASP C 747 
AA4 3  4  N LEU A 746 ? N LEU C 746 O ARG A 774 ? O ARG C 774 
AA4 4  5  N LEU A 775 ? N LEU C 775 O GLU A 802 ? O GLU C 802 
AA4 5  6  N LEU A 803 ? N LEU C 803 O LYS A 831 ? O LYS C 831 
AA4 6  7  N LEU A 832 ? N LEU C 832 O ARG A 859 ? O ARG C 859 
AA4 7  8  N LEU A 860 ? N LEU C 860 O GLY A 890 ? O GLY C 890 
AA4 8  9  N LEU A 889 ? N LEU C 889 O HIS A 916 ? O HIS C 916 
AA4 9  10 N LEU A 917 ? N LEU C 917 O VAL A 945 ? O VAL C 945 
AA4 10 11 N LEU A 948 ? N LEU C 948 O SER A 975 ? O SER C 975 
# 
_pdbx_entry_details.entry_id                   9MGY 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             N 
_pdbx_validate_rmsd_angle.auth_asym_id_1             C 
_pdbx_validate_rmsd_angle.auth_comp_id_1             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_1              625 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             C 
_pdbx_validate_rmsd_angle.auth_comp_id_2             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_2              625 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             C 
_pdbx_validate_rmsd_angle.auth_asym_id_3             C 
_pdbx_validate_rmsd_angle.auth_comp_id_3             PRO 
_pdbx_validate_rmsd_angle.auth_seq_id_3              625 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                89.55 
_pdbx_validate_rmsd_angle.angle_target_value         112.10 
_pdbx_validate_rmsd_angle.angle_deviation            -22.55 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.60 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU C 164 ? ? 60.53   88.43   
2  1 TYR C 168 ? ? -37.36  123.25  
3  1 ASP C 212 ? ? -79.98  -167.06 
4  1 CYS C 279 ? ? -119.62 -139.63 
5  1 LYS C 289 ? ? -90.03  -147.45 
6  1 SER C 295 ? ? 81.25   -16.36  
7  1 CYS C 319 ? ? 55.96   76.12   
8  1 ASP C 321 ? ? 88.79   112.35  
9  1 ASP C 363 ? ? 63.75   -70.51  
10 1 LYS C 496 ? ? 56.49   -69.66  
11 1 GLU C 511 ? ? 79.78   138.22  
12 1 SER C 555 ? ? -173.53 -58.24  
13 1 TYR C 572 ? ? 68.30   -20.73  
14 1 THR C 589 ? ? -125.03 -165.33 
15 1 TYR C 591 ? ? 65.91   92.52   
16 1 LEU C 592 ? ? 73.01   -54.08  
17 1 PRO C 625 ? ? -141.82 58.48   
18 1 SER C 626 ? ? -61.88  40.01   
19 1 GLN C 627 ? ? 68.12   -60.39  
20 1 THR C 726 ? ? 67.36   -6.27   
21 1 SER C 727 ? ? -138.86 -154.39 
22 1 ALA C 866 ? ? -98.46  51.39   
23 1 VAL C 892 ? ? -85.06  -101.05 
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             GLN 
_pdbx_validate_main_chain_plane.auth_asym_id             C 
_pdbx_validate_main_chain_plane.auth_seq_id              624 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             ? 
_pdbx_validate_main_chain_plane.improper_torsion_angle   14.42 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9MGY 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9MGY 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               424304 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'NLRP3 hexamer' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9MGY 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2400 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9MGY 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9MGY 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 C MET 1    ? A MET 1    
2   1 Y 1 C LYS 2    ? A LYS 2    
3   1 Y 1 C MET 3    ? A MET 3    
4   1 Y 1 C ALA 4    ? A ALA 4    
5   1 Y 1 C SER 5    ? A SER 5    
6   1 Y 1 C THR 6    ? A THR 6    
7   1 Y 1 C ARG 7    ? A ARG 7    
8   1 Y 1 C CYS 8    ? A CYS 8    
9   1 Y 1 C LYS 9    ? A LYS 9    
10  1 Y 1 C LEU 10   ? A LEU 10   
11  1 Y 1 C ALA 11   ? A ALA 11   
12  1 Y 1 C ARG 12   ? A ARG 12   
13  1 Y 1 C TYR 13   ? A TYR 13   
14  1 Y 1 C LEU 14   ? A LEU 14   
15  1 Y 1 C GLU 15   ? A GLU 15   
16  1 Y 1 C ASP 16   ? A ASP 16   
17  1 Y 1 C LEU 17   ? A LEU 17   
18  1 Y 1 C GLU 18   ? A GLU 18   
19  1 Y 1 C ASP 19   ? A ASP 19   
20  1 Y 1 C VAL 20   ? A VAL 20   
21  1 Y 1 C ASP 21   ? A ASP 21   
22  1 Y 1 C LEU 22   ? A LEU 22   
23  1 Y 1 C LYS 23   ? A LYS 23   
24  1 Y 1 C LYS 24   ? A LYS 24   
25  1 Y 1 C PHE 25   ? A PHE 25   
26  1 Y 1 C LYS 26   ? A LYS 26   
27  1 Y 1 C MET 27   ? A MET 27   
28  1 Y 1 C HIS 28   ? A HIS 28   
29  1 Y 1 C LEU 29   ? A LEU 29   
30  1 Y 1 C GLU 30   ? A GLU 30   
31  1 Y 1 C ASP 31   ? A ASP 31   
32  1 Y 1 C TYR 32   ? A TYR 32   
33  1 Y 1 C PRO 33   ? A PRO 33   
34  1 Y 1 C PRO 34   ? A PRO 34   
35  1 Y 1 C GLN 35   ? A GLN 35   
36  1 Y 1 C LYS 36   ? A LYS 36   
37  1 Y 1 C GLY 37   ? A GLY 37   
38  1 Y 1 C CYS 38   ? A CYS 38   
39  1 Y 1 C ILE 39   ? A ILE 39   
40  1 Y 1 C PRO 40   ? A PRO 40   
41  1 Y 1 C LEU 41   ? A LEU 41   
42  1 Y 1 C PRO 42   ? A PRO 42   
43  1 Y 1 C ARG 43   ? A ARG 43   
44  1 Y 1 C GLY 44   ? A GLY 44   
45  1 Y 1 C GLN 45   ? A GLN 45   
46  1 Y 1 C THR 46   ? A THR 46   
47  1 Y 1 C GLU 47   ? A GLU 47   
48  1 Y 1 C LYS 48   ? A LYS 48   
49  1 Y 1 C ALA 49   ? A ALA 49   
50  1 Y 1 C ASP 50   ? A ASP 50   
51  1 Y 1 C HIS 51   ? A HIS 51   
52  1 Y 1 C VAL 52   ? A VAL 52   
53  1 Y 1 C ASP 53   ? A ASP 53   
54  1 Y 1 C LEU 54   ? A LEU 54   
55  1 Y 1 C ALA 55   ? A ALA 55   
56  1 Y 1 C THR 56   ? A THR 56   
57  1 Y 1 C LEU 57   ? A LEU 57   
58  1 Y 1 C MET 58   ? A MET 58   
59  1 Y 1 C ILE 59   ? A ILE 59   
60  1 Y 1 C ASP 60   ? A ASP 60   
61  1 Y 1 C PHE 61   ? A PHE 61   
62  1 Y 1 C ASN 62   ? A ASN 62   
63  1 Y 1 C GLY 63   ? A GLY 63   
64  1 Y 1 C GLU 64   ? A GLU 64   
65  1 Y 1 C GLU 65   ? A GLU 65   
66  1 Y 1 C LYS 66   ? A LYS 66   
67  1 Y 1 C ALA 67   ? A ALA 67   
68  1 Y 1 C TRP 68   ? A TRP 68   
69  1 Y 1 C ALA 69   ? A ALA 69   
70  1 Y 1 C MET 70   ? A MET 70   
71  1 Y 1 C ALA 71   ? A ALA 71   
72  1 Y 1 C VAL 72   ? A VAL 72   
73  1 Y 1 C TRP 73   ? A TRP 73   
74  1 Y 1 C ILE 74   ? A ILE 74   
75  1 Y 1 C PHE 75   ? A PHE 75   
76  1 Y 1 C ALA 76   ? A ALA 76   
77  1 Y 1 C ALA 77   ? A ALA 77   
78  1 Y 1 C ILE 78   ? A ILE 78   
79  1 Y 1 C ASN 79   ? A ASN 79   
80  1 Y 1 C ARG 80   ? A ARG 80   
81  1 Y 1 C ARG 81   ? A ARG 81   
82  1 Y 1 C ASP 82   ? A ASP 82   
83  1 Y 1 C LEU 83   ? A LEU 83   
84  1 Y 1 C TYR 84   ? A TYR 84   
85  1 Y 1 C GLU 85   ? A GLU 85   
86  1 Y 1 C LYS 86   ? A LYS 86   
87  1 Y 1 C ALA 87   ? A ALA 87   
88  1 Y 1 C LYS 88   ? A LYS 88   
89  1 Y 1 C ARG 89   ? A ARG 89   
90  1 Y 1 C ASP 90   ? A ASP 90   
91  1 Y 1 C GLU 91   ? A GLU 91   
92  1 Y 1 C PRO 92   ? A PRO 92   
93  1 Y 1 C LYS 93   ? A LYS 93   
94  1 Y 1 C TRP 94   ? A TRP 94   
95  1 Y 1 C GLY 95   ? A GLY 95   
96  1 Y 1 C SER 96   ? A SER 96   
97  1 Y 1 C ASP 97   ? A ASP 97   
98  1 Y 1 C ASN 98   ? A ASN 98   
99  1 Y 1 C ALA 99   ? A ALA 99   
100 1 Y 1 C ARG 100  ? A ARG 100  
101 1 Y 1 C VAL 101  ? A VAL 101  
102 1 Y 1 C SER 102  ? A SER 102  
103 1 Y 1 C ASN 103  ? A ASN 103  
104 1 Y 1 C PRO 104  ? A PRO 104  
105 1 Y 1 C THR 105  ? A THR 105  
106 1 Y 1 C VAL 106  ? A VAL 106  
107 1 Y 1 C ILE 107  ? A ILE 107  
108 1 Y 1 C CYS 108  ? A CYS 108  
109 1 Y 1 C GLN 109  ? A GLN 109  
110 1 Y 1 C GLU 110  ? A GLU 110  
111 1 Y 1 C ASP 111  ? A ASP 111  
112 1 Y 1 C SER 112  ? A SER 112  
113 1 Y 1 C ILE 113  ? A ILE 113  
114 1 Y 1 C GLU 114  ? A GLU 114  
115 1 Y 1 C GLU 115  ? A GLU 115  
116 1 Y 1 C GLU 116  ? A GLU 116  
117 1 Y 1 C TRP 117  ? A TRP 117  
118 1 Y 1 C MET 118  ? A MET 118  
119 1 Y 1 C GLY 119  ? A GLY 119  
120 1 Y 1 C LEU 120  ? A LEU 120  
121 1 Y 1 C LEU 121  ? A LEU 121  
122 1 Y 1 C GLU 122  ? A GLU 122  
123 1 Y 1 C TYR 123  ? A TYR 123  
124 1 Y 1 C LEU 124  ? A LEU 124  
125 1 Y 1 C SER 125  ? A SER 125  
126 1 Y 1 C ARG 126  ? A ARG 126  
127 1 Y 1 C ILE 127  ? A ILE 127  
128 1 Y 1 C SER 128  ? A SER 128  
129 1 Y 1 C ILE 129  ? A ILE 129  
130 1 Y 1 C CYS 130  ? A CYS 130  
131 1 Y 1 C LYS 131  ? A LYS 131  
132 1 Y 1 C MET 132  ? A MET 132  
133 1 Y 1 C HIS 177  ? A HIS 177  
134 1 Y 1 C ARG 178  ? A ARG 178  
135 1 Y 1 C SER 179  ? A SER 179  
136 1 Y 1 C GLN 180  ? A GLN 180  
137 1 Y 1 C GLN 181  ? A GLN 181  
138 1 Y 1 C GLU 182  ? A GLU 182  
139 1 Y 1 C ARG 183  ? A ARG 183  
140 1 Y 1 C GLU 184  ? A GLU 184  
141 1 Y 1 C GLN 185  ? A GLN 185  
142 1 Y 1 C GLU 186  ? A GLU 186  
143 1 Y 1 C LEU 187  ? A LEU 187  
144 1 Y 1 C LEU 188  ? A LEU 188  
145 1 Y 1 C ALA 189  ? A ALA 189  
146 1 Y 1 C ILE 190  ? A ILE 190  
147 1 Y 1 C GLY 191  ? A GLY 191  
148 1 Y 1 C LYS 192  ? A LYS 192  
149 1 Y 1 C THR 193  ? A THR 193  
150 1 Y 1 C LYS 194  ? A LYS 194  
151 1 Y 1 C THR 195  ? A THR 195  
152 1 Y 1 C CYS 196  ? A CYS 196  
153 1 Y 1 C GLU 197  ? A GLU 197  
154 1 Y 1 C SER 198  ? A SER 198  
155 1 Y 1 C PRO 199  ? A PRO 199  
156 1 Y 1 C VAL 200  ? A VAL 200  
157 1 Y 1 C ARG 454  ? A ARG 454  
158 1 Y 1 C GLY 455  ? A GLY 455  
159 1 Y 1 C GLY 456  ? A GLY 456  
160 1 Y 1 C SER 457  ? A SER 457  
161 1 Y 1 C GLN 458  ? A GLN 458  
162 1 Y 1 C GLU 459  ? A GLU 459  
163 1 Y 1 C HIS 460  ? A HIS 460  
164 1 Y 1 C GLY 461  ? A GLY 461  
165 1 Y 1 C GLU 538  ? A GLU 538  
166 1 Y 1 C GLU 539  ? A GLU 539  
167 1 Y 1 C LYS 540  ? A LYS 540  
168 1 Y 1 C GLU 541  ? A GLU 541  
169 1 Y 1 C GLY 542  ? A GLY 542  
170 1 Y 1 C ARG 543  ? A ARG 543  
171 1 Y 1 C THR 544  ? A THR 544  
172 1 Y 1 C ASN 545  ? A ASN 545  
173 1 Y 1 C VAL 546  ? A VAL 546  
174 1 Y 1 C PRO 547  ? A PRO 547  
175 1 Y 1 C GLY 548  ? A GLY 548  
176 1 Y 1 C SER 549  ? A SER 549  
177 1 Y 1 C ARG 550  ? A ARG 550  
178 1 Y 1 C LEU 551  ? A LEU 551  
179 1 Y 1 C LYS 552  ? A LYS 552  
180 1 Y 1 C MET 687  ? A MET 687  
181 1 Y 1 C PRO 688  ? A PRO 688  
182 1 Y 1 C LYS 689  ? A LYS 689  
183 1 Y 1 C GLU 690  ? A GLU 690  
184 1 Y 1 C GLU 691  ? A GLU 691  
185 1 Y 1 C GLU 692  ? A GLU 692  
186 1 Y 1 C GLU 693  ? A GLU 693  
187 1 Y 1 C GLU 694  ? A GLU 694  
188 1 Y 1 C GLU 695  ? A GLU 695  
189 1 Y 1 C LYS 696  ? A LYS 696  
190 1 Y 1 C GLU 697  ? A GLU 697  
191 1 Y 1 C GLY 698  ? A GLY 698  
192 1 Y 1 C ARG 699  ? A ARG 699  
193 1 Y 1 C HIS 700  ? A HIS 700  
194 1 Y 1 C LEU 701  ? A LEU 701  
195 1 Y 1 C ASP 702  ? A ASP 702  
196 1 Y 1 C MET 703  ? A MET 703  
197 1 Y 1 C VAL 704  ? A VAL 704  
198 1 Y 1 C GLN 705  ? A GLN 705  
199 1 Y 1 C CYS 706  ? A CYS 706  
200 1 Y 1 C VAL 707  ? A VAL 707  
201 1 Y 1 C LEU 708  ? A LEU 708  
202 1 Y 1 C PRO 709  ? A PRO 709  
203 1 Y 1 C SER 710  ? A SER 710  
204 1 Y 1 C SER 711  ? A SER 711  
205 1 Y 1 C SER 712  ? A SER 712  
206 1 Y 1 C HIS 713  ? A HIS 713  
207 1 Y 1 C ALA 714  ? A ALA 714  
208 1 Y 1 C ALA 715  ? A ALA 715  
209 1 Y 1 C CYS 716  ? A CYS 716  
210 1 Y 1 C SER 717  ? A SER 717  
211 1 Y 1 C HIS 718  ? A HIS 718  
212 1 Y 1 C GLY 719  ? A GLY 719  
213 1 Y 1 C LEU 720  ? A LEU 720  
214 1 Y 1 C VAL 721  ? A VAL 721  
215 1 Y 1 C ASN 722  ? A ASN 722  
216 1 Y 1 C SER 723  ? A SER 723  
217 1 Y 1 C HIS 724  ? A HIS 724  
218 1 Y 1 C TRP 1036 ? A TRP 1036 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BLR N1     N N N 1   
A1BLR N3     N Y N 2   
A1BLR C4     C N N 3   
A1BLR C5     C N R 4   
A1BLR C6     C N N 5   
A1BLR C7     C Y N 6   
A1BLR C8     C Y N 7   
A1BLR C10    C Y N 8   
A1BLR C13    C Y N 9   
A1BLR C15    C Y N 10  
A1BLR C17    C N N 11  
A1BLR C1     C N N 12  
A1BLR O1     O N N 13  
A1BLR C2     C N N 14  
A1BLR N2     N N N 15  
A1BLR C3     C N N 16  
A1BLR N4     N Y N 17  
A1BLR C9     C Y N 18  
A1BLR C11    C Y N 19  
A1BLR C12    C Y N 20  
A1BLR C14    C Y N 21  
A1BLR C16    C Y N 22  
A1BLR F1     F N N 23  
A1BLR F2     F N N 24  
A1BLR F3     F N N 25  
A1BLR H2     H N N 26  
A1BLR H3     H N N 27  
A1BLR H4     H N N 28  
A1BLR H5     H N N 29  
A1BLR H6     H N N 30  
A1BLR H7     H N N 31  
A1BLR H8     H N N 32  
A1BLR H9     H N N 33  
A1BLR H10    H N N 34  
A1BLR H11    H N N 35  
A1BLR H12    H N N 36  
A1BLR H13    H N N 37  
A1BLR H14    H N N 38  
A1BLR H15    H N N 39  
A1BLR H16    H N N 40  
A1BLR H17    H N N 41  
A1BLR H18    H N N 42  
A1BLR H19    H N N 43  
A1BLR H20    H N N 44  
ALA   N      N N N 45  
ALA   CA     C N S 46  
ALA   C      C N N 47  
ALA   O      O N N 48  
ALA   CB     C N N 49  
ALA   OXT    O N N 50  
ALA   H      H N N 51  
ALA   H2     H N N 52  
ALA   HA     H N N 53  
ALA   HB1    H N N 54  
ALA   HB2    H N N 55  
ALA   HB3    H N N 56  
ALA   HXT    H N N 57  
ARG   N      N N N 58  
ARG   CA     C N S 59  
ARG   C      C N N 60  
ARG   O      O N N 61  
ARG   CB     C N N 62  
ARG   CG     C N N 63  
ARG   CD     C N N 64  
ARG   NE     N N N 65  
ARG   CZ     C N N 66  
ARG   NH1    N N N 67  
ARG   NH2    N N N 68  
ARG   OXT    O N N 69  
ARG   H      H N N 70  
ARG   H2     H N N 71  
ARG   HA     H N N 72  
ARG   HB2    H N N 73  
ARG   HB3    H N N 74  
ARG   HG2    H N N 75  
ARG   HG3    H N N 76  
ARG   HD2    H N N 77  
ARG   HD3    H N N 78  
ARG   HE     H N N 79  
ARG   HH11   H N N 80  
ARG   HH12   H N N 81  
ARG   HH21   H N N 82  
ARG   HH22   H N N 83  
ARG   HXT    H N N 84  
ASN   N      N N N 85  
ASN   CA     C N S 86  
ASN   C      C N N 87  
ASN   O      O N N 88  
ASN   CB     C N N 89  
ASN   CG     C N N 90  
ASN   OD1    O N N 91  
ASN   ND2    N N N 92  
ASN   OXT    O N N 93  
ASN   H      H N N 94  
ASN   H2     H N N 95  
ASN   HA     H N N 96  
ASN   HB2    H N N 97  
ASN   HB3    H N N 98  
ASN   HD21   H N N 99  
ASN   HD22   H N N 100 
ASN   HXT    H N N 101 
ASP   N      N N N 102 
ASP   CA     C N S 103 
ASP   C      C N N 104 
ASP   O      O N N 105 
ASP   CB     C N N 106 
ASP   CG     C N N 107 
ASP   OD1    O N N 108 
ASP   OD2    O N N 109 
ASP   OXT    O N N 110 
ASP   H      H N N 111 
ASP   H2     H N N 112 
ASP   HA     H N N 113 
ASP   HB2    H N N 114 
ASP   HB3    H N N 115 
ASP   HD2    H N N 116 
ASP   HXT    H N N 117 
ATP   PG     P N N 118 
ATP   O1G    O N N 119 
ATP   O2G    O N N 120 
ATP   O3G    O N N 121 
ATP   PB     P N R 122 
ATP   O1B    O N N 123 
ATP   O2B    O N N 124 
ATP   O3B    O N N 125 
ATP   PA     P N R 126 
ATP   O1A    O N N 127 
ATP   O2A    O N N 128 
ATP   O3A    O N N 129 
ATP   "O5'"  O N N 130 
ATP   "C5'"  C N N 131 
ATP   "C4'"  C N R 132 
ATP   "O4'"  O N N 133 
ATP   "C3'"  C N S 134 
ATP   "O3'"  O N N 135 
ATP   "C2'"  C N R 136 
ATP   "O2'"  O N N 137 
ATP   "C1'"  C N R 138 
ATP   N9     N Y N 139 
ATP   C8     C Y N 140 
ATP   N7     N Y N 141 
ATP   C5     C Y N 142 
ATP   C6     C Y N 143 
ATP   N6     N N N 144 
ATP   N1     N Y N 145 
ATP   C2     C Y N 146 
ATP   N3     N Y N 147 
ATP   C4     C Y N 148 
ATP   HOG2   H N N 149 
ATP   HOG3   H N N 150 
ATP   HOB2   H N N 151 
ATP   HOA2   H N N 152 
ATP   "H5'1" H N N 153 
ATP   "H5'2" H N N 154 
ATP   "H4'"  H N N 155 
ATP   "H3'"  H N N 156 
ATP   "HO3'" H N N 157 
ATP   "H2'"  H N N 158 
ATP   "HO2'" H N N 159 
ATP   "H1'"  H N N 160 
ATP   H8     H N N 161 
ATP   HN61   H N N 162 
ATP   HN62   H N N 163 
ATP   H2     H N N 164 
CYS   N      N N N 165 
CYS   CA     C N R 166 
CYS   C      C N N 167 
CYS   O      O N N 168 
CYS   CB     C N N 169 
CYS   SG     S N N 170 
CYS   OXT    O N N 171 
CYS   H      H N N 172 
CYS   H2     H N N 173 
CYS   HA     H N N 174 
CYS   HB2    H N N 175 
CYS   HB3    H N N 176 
CYS   HG     H N N 177 
CYS   HXT    H N N 178 
GLN   N      N N N 179 
GLN   CA     C N S 180 
GLN   C      C N N 181 
GLN   O      O N N 182 
GLN   CB     C N N 183 
GLN   CG     C N N 184 
GLN   CD     C N N 185 
GLN   OE1    O N N 186 
GLN   NE2    N N N 187 
GLN   OXT    O N N 188 
GLN   H      H N N 189 
GLN   H2     H N N 190 
GLN   HA     H N N 191 
GLN   HB2    H N N 192 
GLN   HB3    H N N 193 
GLN   HG2    H N N 194 
GLN   HG3    H N N 195 
GLN   HE21   H N N 196 
GLN   HE22   H N N 197 
GLN   HXT    H N N 198 
GLU   N      N N N 199 
GLU   CA     C N S 200 
GLU   C      C N N 201 
GLU   O      O N N 202 
GLU   CB     C N N 203 
GLU   CG     C N N 204 
GLU   CD     C N N 205 
GLU   OE1    O N N 206 
GLU   OE2    O N N 207 
GLU   OXT    O N N 208 
GLU   H      H N N 209 
GLU   H2     H N N 210 
GLU   HA     H N N 211 
GLU   HB2    H N N 212 
GLU   HB3    H N N 213 
GLU   HG2    H N N 214 
GLU   HG3    H N N 215 
GLU   HE2    H N N 216 
GLU   HXT    H N N 217 
GLY   N      N N N 218 
GLY   CA     C N N 219 
GLY   C      C N N 220 
GLY   O      O N N 221 
GLY   OXT    O N N 222 
GLY   H      H N N 223 
GLY   H2     H N N 224 
GLY   HA2    H N N 225 
GLY   HA3    H N N 226 
GLY   HXT    H N N 227 
HIS   N      N N N 228 
HIS   CA     C N S 229 
HIS   C      C N N 230 
HIS   O      O N N 231 
HIS   CB     C N N 232 
HIS   CG     C Y N 233 
HIS   ND1    N Y N 234 
HIS   CD2    C Y N 235 
HIS   CE1    C Y N 236 
HIS   NE2    N Y N 237 
HIS   OXT    O N N 238 
HIS   H      H N N 239 
HIS   H2     H N N 240 
HIS   HA     H N N 241 
HIS   HB2    H N N 242 
HIS   HB3    H N N 243 
HIS   HD1    H N N 244 
HIS   HD2    H N N 245 
HIS   HE1    H N N 246 
HIS   HE2    H N N 247 
HIS   HXT    H N N 248 
HOH   O      O N N 249 
HOH   H1     H N N 250 
HOH   H2     H N N 251 
ILE   N      N N N 252 
ILE   CA     C N S 253 
ILE   C      C N N 254 
ILE   O      O N N 255 
ILE   CB     C N S 256 
ILE   CG1    C N N 257 
ILE   CG2    C N N 258 
ILE   CD1    C N N 259 
ILE   OXT    O N N 260 
ILE   H      H N N 261 
ILE   H2     H N N 262 
ILE   HA     H N N 263 
ILE   HB     H N N 264 
ILE   HG12   H N N 265 
ILE   HG13   H N N 266 
ILE   HG21   H N N 267 
ILE   HG22   H N N 268 
ILE   HG23   H N N 269 
ILE   HD11   H N N 270 
ILE   HD12   H N N 271 
ILE   HD13   H N N 272 
ILE   HXT    H N N 273 
LEU   N      N N N 274 
LEU   CA     C N S 275 
LEU   C      C N N 276 
LEU   O      O N N 277 
LEU   CB     C N N 278 
LEU   CG     C N N 279 
LEU   CD1    C N N 280 
LEU   CD2    C N N 281 
LEU   OXT    O N N 282 
LEU   H      H N N 283 
LEU   H2     H N N 284 
LEU   HA     H N N 285 
LEU   HB2    H N N 286 
LEU   HB3    H N N 287 
LEU   HG     H N N 288 
LEU   HD11   H N N 289 
LEU   HD12   H N N 290 
LEU   HD13   H N N 291 
LEU   HD21   H N N 292 
LEU   HD22   H N N 293 
LEU   HD23   H N N 294 
LEU   HXT    H N N 295 
LYS   N      N N N 296 
LYS   CA     C N S 297 
LYS   C      C N N 298 
LYS   O      O N N 299 
LYS   CB     C N N 300 
LYS   CG     C N N 301 
LYS   CD     C N N 302 
LYS   CE     C N N 303 
LYS   NZ     N N N 304 
LYS   OXT    O N N 305 
LYS   H      H N N 306 
LYS   H2     H N N 307 
LYS   HA     H N N 308 
LYS   HB2    H N N 309 
LYS   HB3    H N N 310 
LYS   HG2    H N N 311 
LYS   HG3    H N N 312 
LYS   HD2    H N N 313 
LYS   HD3    H N N 314 
LYS   HE2    H N N 315 
LYS   HE3    H N N 316 
LYS   HZ1    H N N 317 
LYS   HZ2    H N N 318 
LYS   HZ3    H N N 319 
LYS   HXT    H N N 320 
MET   N      N N N 321 
MET   CA     C N S 322 
MET   C      C N N 323 
MET   O      O N N 324 
MET   CB     C N N 325 
MET   CG     C N N 326 
MET   SD     S N N 327 
MET   CE     C N N 328 
MET   OXT    O N N 329 
MET   H      H N N 330 
MET   H2     H N N 331 
MET   HA     H N N 332 
MET   HB2    H N N 333 
MET   HB3    H N N 334 
MET   HG2    H N N 335 
MET   HG3    H N N 336 
MET   HE1    H N N 337 
MET   HE2    H N N 338 
MET   HE3    H N N 339 
MET   HXT    H N N 340 
PHE   N      N N N 341 
PHE   CA     C N S 342 
PHE   C      C N N 343 
PHE   O      O N N 344 
PHE   CB     C N N 345 
PHE   CG     C Y N 346 
PHE   CD1    C Y N 347 
PHE   CD2    C Y N 348 
PHE   CE1    C Y N 349 
PHE   CE2    C Y N 350 
PHE   CZ     C Y N 351 
PHE   OXT    O N N 352 
PHE   H      H N N 353 
PHE   H2     H N N 354 
PHE   HA     H N N 355 
PHE   HB2    H N N 356 
PHE   HB3    H N N 357 
PHE   HD1    H N N 358 
PHE   HD2    H N N 359 
PHE   HE1    H N N 360 
PHE   HE2    H N N 361 
PHE   HZ     H N N 362 
PHE   HXT    H N N 363 
PRO   N      N N N 364 
PRO   CA     C N S 365 
PRO   C      C N N 366 
PRO   O      O N N 367 
PRO   CB     C N N 368 
PRO   CG     C N N 369 
PRO   CD     C N N 370 
PRO   OXT    O N N 371 
PRO   H      H N N 372 
PRO   HA     H N N 373 
PRO   HB2    H N N 374 
PRO   HB3    H N N 375 
PRO   HG2    H N N 376 
PRO   HG3    H N N 377 
PRO   HD2    H N N 378 
PRO   HD3    H N N 379 
PRO   HXT    H N N 380 
SER   N      N N N 381 
SER   CA     C N S 382 
SER   C      C N N 383 
SER   O      O N N 384 
SER   CB     C N N 385 
SER   OG     O N N 386 
SER   OXT    O N N 387 
SER   H      H N N 388 
SER   H2     H N N 389 
SER   HA     H N N 390 
SER   HB2    H N N 391 
SER   HB3    H N N 392 
SER   HG     H N N 393 
SER   HXT    H N N 394 
THR   N      N N N 395 
THR   CA     C N S 396 
THR   C      C N N 397 
THR   O      O N N 398 
THR   CB     C N R 399 
THR   OG1    O N N 400 
THR   CG2    C N N 401 
THR   OXT    O N N 402 
THR   H      H N N 403 
THR   H2     H N N 404 
THR   HA     H N N 405 
THR   HB     H N N 406 
THR   HG1    H N N 407 
THR   HG21   H N N 408 
THR   HG22   H N N 409 
THR   HG23   H N N 410 
THR   HXT    H N N 411 
TRP   N      N N N 412 
TRP   CA     C N S 413 
TRP   C      C N N 414 
TRP   O      O N N 415 
TRP   CB     C N N 416 
TRP   CG     C Y N 417 
TRP   CD1    C Y N 418 
TRP   CD2    C Y N 419 
TRP   NE1    N Y N 420 
TRP   CE2    C Y N 421 
TRP   CE3    C Y N 422 
TRP   CZ2    C Y N 423 
TRP   CZ3    C Y N 424 
TRP   CH2    C Y N 425 
TRP   OXT    O N N 426 
TRP   H      H N N 427 
TRP   H2     H N N 428 
TRP   HA     H N N 429 
TRP   HB2    H N N 430 
TRP   HB3    H N N 431 
TRP   HD1    H N N 432 
TRP   HE1    H N N 433 
TRP   HE3    H N N 434 
TRP   HZ2    H N N 435 
TRP   HZ3    H N N 436 
TRP   HH2    H N N 437 
TRP   HXT    H N N 438 
TYR   N      N N N 439 
TYR   CA     C N S 440 
TYR   C      C N N 441 
TYR   O      O N N 442 
TYR   CB     C N N 443 
TYR   CG     C Y N 444 
TYR   CD1    C Y N 445 
TYR   CD2    C Y N 446 
TYR   CE1    C Y N 447 
TYR   CE2    C Y N 448 
TYR   CZ     C Y N 449 
TYR   OH     O N N 450 
TYR   OXT    O N N 451 
TYR   H      H N N 452 
TYR   H2     H N N 453 
TYR   HA     H N N 454 
TYR   HB2    H N N 455 
TYR   HB3    H N N 456 
TYR   HD1    H N N 457 
TYR   HD2    H N N 458 
TYR   HE1    H N N 459 
TYR   HE2    H N N 460 
TYR   HH     H N N 461 
TYR   HXT    H N N 462 
VAL   N      N N N 463 
VAL   CA     C N S 464 
VAL   C      C N N 465 
VAL   O      O N N 466 
VAL   CB     C N N 467 
VAL   CG1    C N N 468 
VAL   CG2    C N N 469 
VAL   OXT    O N N 470 
VAL   H      H N N 471 
VAL   H2     H N N 472 
VAL   HA     H N N 473 
VAL   HB     H N N 474 
VAL   HG11   H N N 475 
VAL   HG12   H N N 476 
VAL   HG13   H N N 477 
VAL   HG21   H N N 478 
VAL   HG22   H N N 479 
VAL   HG23   H N N 480 
VAL   HXT    H N N 481 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BLR C8    C9     doub Y N 1   
A1BLR C8    C7     sing Y N 2   
A1BLR C9    C10    sing Y N 3   
A1BLR N2    C7     sing N N 4   
A1BLR N2    C5     sing N N 5   
A1BLR C7    N4     doub Y N 6   
A1BLR C10   C11    sing N N 7   
A1BLR C10   N3     doub Y N 8   
A1BLR O1    C16    sing N N 9   
A1BLR C11   C16    doub Y N 10  
A1BLR C11   C12    sing Y N 11  
A1BLR C16   C15    sing Y N 12  
A1BLR C4    C5     sing N N 13  
A1BLR C4    C3     sing N N 14  
A1BLR C12   C13    doub Y N 15  
A1BLR F2    C17    sing N N 16  
A1BLR C15   C14    doub Y N 17  
A1BLR F1    C17    sing N N 18  
A1BLR C13   C14    sing Y N 19  
A1BLR N4    N3     sing Y N 20  
A1BLR C14   C17    sing N N 21  
A1BLR C5    C6     sing N N 22  
A1BLR C17   F3     sing N N 23  
A1BLR C3    C2     sing N N 24  
A1BLR C6    N1     sing N N 25  
A1BLR C2    N1     sing N N 26  
A1BLR N1    C1     sing N N 27  
A1BLR C4    H2     sing N N 28  
A1BLR C4    H3     sing N N 29  
A1BLR C5    H4     sing N N 30  
A1BLR C6    H5     sing N N 31  
A1BLR C6    H6     sing N N 32  
A1BLR C8    H7     sing N N 33  
A1BLR C13   H8     sing N N 34  
A1BLR C15   H9     sing N N 35  
A1BLR C1    H10    sing N N 36  
A1BLR C1    H11    sing N N 37  
A1BLR C1    H12    sing N N 38  
A1BLR O1    H13    sing N N 39  
A1BLR C2    H14    sing N N 40  
A1BLR C2    H15    sing N N 41  
A1BLR N2    H16    sing N N 42  
A1BLR C3    H17    sing N N 43  
A1BLR C3    H18    sing N N 44  
A1BLR C9    H19    sing N N 45  
A1BLR C12   H20    sing N N 46  
ALA   N     CA     sing N N 47  
ALA   N     H      sing N N 48  
ALA   N     H2     sing N N 49  
ALA   CA    C      sing N N 50  
ALA   CA    CB     sing N N 51  
ALA   CA    HA     sing N N 52  
ALA   C     O      doub N N 53  
ALA   C     OXT    sing N N 54  
ALA   CB    HB1    sing N N 55  
ALA   CB    HB2    sing N N 56  
ALA   CB    HB3    sing N N 57  
ALA   OXT   HXT    sing N N 58  
ARG   N     CA     sing N N 59  
ARG   N     H      sing N N 60  
ARG   N     H2     sing N N 61  
ARG   CA    C      sing N N 62  
ARG   CA    CB     sing N N 63  
ARG   CA    HA     sing N N 64  
ARG   C     O      doub N N 65  
ARG   C     OXT    sing N N 66  
ARG   CB    CG     sing N N 67  
ARG   CB    HB2    sing N N 68  
ARG   CB    HB3    sing N N 69  
ARG   CG    CD     sing N N 70  
ARG   CG    HG2    sing N N 71  
ARG   CG    HG3    sing N N 72  
ARG   CD    NE     sing N N 73  
ARG   CD    HD2    sing N N 74  
ARG   CD    HD3    sing N N 75  
ARG   NE    CZ     sing N N 76  
ARG   NE    HE     sing N N 77  
ARG   CZ    NH1    sing N N 78  
ARG   CZ    NH2    doub N N 79  
ARG   NH1   HH11   sing N N 80  
ARG   NH1   HH12   sing N N 81  
ARG   NH2   HH21   sing N N 82  
ARG   NH2   HH22   sing N N 83  
ARG   OXT   HXT    sing N N 84  
ASN   N     CA     sing N N 85  
ASN   N     H      sing N N 86  
ASN   N     H2     sing N N 87  
ASN   CA    C      sing N N 88  
ASN   CA    CB     sing N N 89  
ASN   CA    HA     sing N N 90  
ASN   C     O      doub N N 91  
ASN   C     OXT    sing N N 92  
ASN   CB    CG     sing N N 93  
ASN   CB    HB2    sing N N 94  
ASN   CB    HB3    sing N N 95  
ASN   CG    OD1    doub N N 96  
ASN   CG    ND2    sing N N 97  
ASN   ND2   HD21   sing N N 98  
ASN   ND2   HD22   sing N N 99  
ASN   OXT   HXT    sing N N 100 
ASP   N     CA     sing N N 101 
ASP   N     H      sing N N 102 
ASP   N     H2     sing N N 103 
ASP   CA    C      sing N N 104 
ASP   CA    CB     sing N N 105 
ASP   CA    HA     sing N N 106 
ASP   C     O      doub N N 107 
ASP   C     OXT    sing N N 108 
ASP   CB    CG     sing N N 109 
ASP   CB    HB2    sing N N 110 
ASP   CB    HB3    sing N N 111 
ASP   CG    OD1    doub N N 112 
ASP   CG    OD2    sing N N 113 
ASP   OD2   HD2    sing N N 114 
ASP   OXT   HXT    sing N N 115 
ATP   PG    O1G    doub N N 116 
ATP   PG    O2G    sing N N 117 
ATP   PG    O3G    sing N N 118 
ATP   PG    O3B    sing N N 119 
ATP   O2G   HOG2   sing N N 120 
ATP   O3G   HOG3   sing N N 121 
ATP   PB    O1B    doub N N 122 
ATP   PB    O2B    sing N N 123 
ATP   PB    O3B    sing N N 124 
ATP   PB    O3A    sing N N 125 
ATP   O2B   HOB2   sing N N 126 
ATP   PA    O1A    doub N N 127 
ATP   PA    O2A    sing N N 128 
ATP   PA    O3A    sing N N 129 
ATP   PA    "O5'"  sing N N 130 
ATP   O2A   HOA2   sing N N 131 
ATP   "O5'" "C5'"  sing N N 132 
ATP   "C5'" "C4'"  sing N N 133 
ATP   "C5'" "H5'1" sing N N 134 
ATP   "C5'" "H5'2" sing N N 135 
ATP   "C4'" "O4'"  sing N N 136 
ATP   "C4'" "C3'"  sing N N 137 
ATP   "C4'" "H4'"  sing N N 138 
ATP   "O4'" "C1'"  sing N N 139 
ATP   "C3'" "O3'"  sing N N 140 
ATP   "C3'" "C2'"  sing N N 141 
ATP   "C3'" "H3'"  sing N N 142 
ATP   "O3'" "HO3'" sing N N 143 
ATP   "C2'" "O2'"  sing N N 144 
ATP   "C2'" "C1'"  sing N N 145 
ATP   "C2'" "H2'"  sing N N 146 
ATP   "O2'" "HO2'" sing N N 147 
ATP   "C1'" N9     sing N N 148 
ATP   "C1'" "H1'"  sing N N 149 
ATP   N9    C8     sing Y N 150 
ATP   N9    C4     sing Y N 151 
ATP   C8    N7     doub Y N 152 
ATP   C8    H8     sing N N 153 
ATP   N7    C5     sing Y N 154 
ATP   C5    C6     sing Y N 155 
ATP   C5    C4     doub Y N 156 
ATP   C6    N6     sing N N 157 
ATP   C6    N1     doub Y N 158 
ATP   N6    HN61   sing N N 159 
ATP   N6    HN62   sing N N 160 
ATP   N1    C2     sing Y N 161 
ATP   C2    N3     doub Y N 162 
ATP   C2    H2     sing N N 163 
ATP   N3    C4     sing Y N 164 
CYS   N     CA     sing N N 165 
CYS   N     H      sing N N 166 
CYS   N     H2     sing N N 167 
CYS   CA    C      sing N N 168 
CYS   CA    CB     sing N N 169 
CYS   CA    HA     sing N N 170 
CYS   C     O      doub N N 171 
CYS   C     OXT    sing N N 172 
CYS   CB    SG     sing N N 173 
CYS   CB    HB2    sing N N 174 
CYS   CB    HB3    sing N N 175 
CYS   SG    HG     sing N N 176 
CYS   OXT   HXT    sing N N 177 
GLN   N     CA     sing N N 178 
GLN   N     H      sing N N 179 
GLN   N     H2     sing N N 180 
GLN   CA    C      sing N N 181 
GLN   CA    CB     sing N N 182 
GLN   CA    HA     sing N N 183 
GLN   C     O      doub N N 184 
GLN   C     OXT    sing N N 185 
GLN   CB    CG     sing N N 186 
GLN   CB    HB2    sing N N 187 
GLN   CB    HB3    sing N N 188 
GLN   CG    CD     sing N N 189 
GLN   CG    HG2    sing N N 190 
GLN   CG    HG3    sing N N 191 
GLN   CD    OE1    doub N N 192 
GLN   CD    NE2    sing N N 193 
GLN   NE2   HE21   sing N N 194 
GLN   NE2   HE22   sing N N 195 
GLN   OXT   HXT    sing N N 196 
GLU   N     CA     sing N N 197 
GLU   N     H      sing N N 198 
GLU   N     H2     sing N N 199 
GLU   CA    C      sing N N 200 
GLU   CA    CB     sing N N 201 
GLU   CA    HA     sing N N 202 
GLU   C     O      doub N N 203 
GLU   C     OXT    sing N N 204 
GLU   CB    CG     sing N N 205 
GLU   CB    HB2    sing N N 206 
GLU   CB    HB3    sing N N 207 
GLU   CG    CD     sing N N 208 
GLU   CG    HG2    sing N N 209 
GLU   CG    HG3    sing N N 210 
GLU   CD    OE1    doub N N 211 
GLU   CD    OE2    sing N N 212 
GLU   OE2   HE2    sing N N 213 
GLU   OXT   HXT    sing N N 214 
GLY   N     CA     sing N N 215 
GLY   N     H      sing N N 216 
GLY   N     H2     sing N N 217 
GLY   CA    C      sing N N 218 
GLY   CA    HA2    sing N N 219 
GLY   CA    HA3    sing N N 220 
GLY   C     O      doub N N 221 
GLY   C     OXT    sing N N 222 
GLY   OXT   HXT    sing N N 223 
HIS   N     CA     sing N N 224 
HIS   N     H      sing N N 225 
HIS   N     H2     sing N N 226 
HIS   CA    C      sing N N 227 
HIS   CA    CB     sing N N 228 
HIS   CA    HA     sing N N 229 
HIS   C     O      doub N N 230 
HIS   C     OXT    sing N N 231 
HIS   CB    CG     sing N N 232 
HIS   CB    HB2    sing N N 233 
HIS   CB    HB3    sing N N 234 
HIS   CG    ND1    sing Y N 235 
HIS   CG    CD2    doub Y N 236 
HIS   ND1   CE1    doub Y N 237 
HIS   ND1   HD1    sing N N 238 
HIS   CD2   NE2    sing Y N 239 
HIS   CD2   HD2    sing N N 240 
HIS   CE1   NE2    sing Y N 241 
HIS   CE1   HE1    sing N N 242 
HIS   NE2   HE2    sing N N 243 
HIS   OXT   HXT    sing N N 244 
HOH   O     H1     sing N N 245 
HOH   O     H2     sing N N 246 
ILE   N     CA     sing N N 247 
ILE   N     H      sing N N 248 
ILE   N     H2     sing N N 249 
ILE   CA    C      sing N N 250 
ILE   CA    CB     sing N N 251 
ILE   CA    HA     sing N N 252 
ILE   C     O      doub N N 253 
ILE   C     OXT    sing N N 254 
ILE   CB    CG1    sing N N 255 
ILE   CB    CG2    sing N N 256 
ILE   CB    HB     sing N N 257 
ILE   CG1   CD1    sing N N 258 
ILE   CG1   HG12   sing N N 259 
ILE   CG1   HG13   sing N N 260 
ILE   CG2   HG21   sing N N 261 
ILE   CG2   HG22   sing N N 262 
ILE   CG2   HG23   sing N N 263 
ILE   CD1   HD11   sing N N 264 
ILE   CD1   HD12   sing N N 265 
ILE   CD1   HD13   sing N N 266 
ILE   OXT   HXT    sing N N 267 
LEU   N     CA     sing N N 268 
LEU   N     H      sing N N 269 
LEU   N     H2     sing N N 270 
LEU   CA    C      sing N N 271 
LEU   CA    CB     sing N N 272 
LEU   CA    HA     sing N N 273 
LEU   C     O      doub N N 274 
LEU   C     OXT    sing N N 275 
LEU   CB    CG     sing N N 276 
LEU   CB    HB2    sing N N 277 
LEU   CB    HB3    sing N N 278 
LEU   CG    CD1    sing N N 279 
LEU   CG    CD2    sing N N 280 
LEU   CG    HG     sing N N 281 
LEU   CD1   HD11   sing N N 282 
LEU   CD1   HD12   sing N N 283 
LEU   CD1   HD13   sing N N 284 
LEU   CD2   HD21   sing N N 285 
LEU   CD2   HD22   sing N N 286 
LEU   CD2   HD23   sing N N 287 
LEU   OXT   HXT    sing N N 288 
LYS   N     CA     sing N N 289 
LYS   N     H      sing N N 290 
LYS   N     H2     sing N N 291 
LYS   CA    C      sing N N 292 
LYS   CA    CB     sing N N 293 
LYS   CA    HA     sing N N 294 
LYS   C     O      doub N N 295 
LYS   C     OXT    sing N N 296 
LYS   CB    CG     sing N N 297 
LYS   CB    HB2    sing N N 298 
LYS   CB    HB3    sing N N 299 
LYS   CG    CD     sing N N 300 
LYS   CG    HG2    sing N N 301 
LYS   CG    HG3    sing N N 302 
LYS   CD    CE     sing N N 303 
LYS   CD    HD2    sing N N 304 
LYS   CD    HD3    sing N N 305 
LYS   CE    NZ     sing N N 306 
LYS   CE    HE2    sing N N 307 
LYS   CE    HE3    sing N N 308 
LYS   NZ    HZ1    sing N N 309 
LYS   NZ    HZ2    sing N N 310 
LYS   NZ    HZ3    sing N N 311 
LYS   OXT   HXT    sing N N 312 
MET   N     CA     sing N N 313 
MET   N     H      sing N N 314 
MET   N     H2     sing N N 315 
MET   CA    C      sing N N 316 
MET   CA    CB     sing N N 317 
MET   CA    HA     sing N N 318 
MET   C     O      doub N N 319 
MET   C     OXT    sing N N 320 
MET   CB    CG     sing N N 321 
MET   CB    HB2    sing N N 322 
MET   CB    HB3    sing N N 323 
MET   CG    SD     sing N N 324 
MET   CG    HG2    sing N N 325 
MET   CG    HG3    sing N N 326 
MET   SD    CE     sing N N 327 
MET   CE    HE1    sing N N 328 
MET   CE    HE2    sing N N 329 
MET   CE    HE3    sing N N 330 
MET   OXT   HXT    sing N N 331 
PHE   N     CA     sing N N 332 
PHE   N     H      sing N N 333 
PHE   N     H2     sing N N 334 
PHE   CA    C      sing N N 335 
PHE   CA    CB     sing N N 336 
PHE   CA    HA     sing N N 337 
PHE   C     O      doub N N 338 
PHE   C     OXT    sing N N 339 
PHE   CB    CG     sing N N 340 
PHE   CB    HB2    sing N N 341 
PHE   CB    HB3    sing N N 342 
PHE   CG    CD1    doub Y N 343 
PHE   CG    CD2    sing Y N 344 
PHE   CD1   CE1    sing Y N 345 
PHE   CD1   HD1    sing N N 346 
PHE   CD2   CE2    doub Y N 347 
PHE   CD2   HD2    sing N N 348 
PHE   CE1   CZ     doub Y N 349 
PHE   CE1   HE1    sing N N 350 
PHE   CE2   CZ     sing Y N 351 
PHE   CE2   HE2    sing N N 352 
PHE   CZ    HZ     sing N N 353 
PHE   OXT   HXT    sing N N 354 
PRO   N     CA     sing N N 355 
PRO   N     CD     sing N N 356 
PRO   N     H      sing N N 357 
PRO   CA    C      sing N N 358 
PRO   CA    CB     sing N N 359 
PRO   CA    HA     sing N N 360 
PRO   C     O      doub N N 361 
PRO   C     OXT    sing N N 362 
PRO   CB    CG     sing N N 363 
PRO   CB    HB2    sing N N 364 
PRO   CB    HB3    sing N N 365 
PRO   CG    CD     sing N N 366 
PRO   CG    HG2    sing N N 367 
PRO   CG    HG3    sing N N 368 
PRO   CD    HD2    sing N N 369 
PRO   CD    HD3    sing N N 370 
PRO   OXT   HXT    sing N N 371 
SER   N     CA     sing N N 372 
SER   N     H      sing N N 373 
SER   N     H2     sing N N 374 
SER   CA    C      sing N N 375 
SER   CA    CB     sing N N 376 
SER   CA    HA     sing N N 377 
SER   C     O      doub N N 378 
SER   C     OXT    sing N N 379 
SER   CB    OG     sing N N 380 
SER   CB    HB2    sing N N 381 
SER   CB    HB3    sing N N 382 
SER   OG    HG     sing N N 383 
SER   OXT   HXT    sing N N 384 
THR   N     CA     sing N N 385 
THR   N     H      sing N N 386 
THR   N     H2     sing N N 387 
THR   CA    C      sing N N 388 
THR   CA    CB     sing N N 389 
THR   CA    HA     sing N N 390 
THR   C     O      doub N N 391 
THR   C     OXT    sing N N 392 
THR   CB    OG1    sing N N 393 
THR   CB    CG2    sing N N 394 
THR   CB    HB     sing N N 395 
THR   OG1   HG1    sing N N 396 
THR   CG2   HG21   sing N N 397 
THR   CG2   HG22   sing N N 398 
THR   CG2   HG23   sing N N 399 
THR   OXT   HXT    sing N N 400 
TRP   N     CA     sing N N 401 
TRP   N     H      sing N N 402 
TRP   N     H2     sing N N 403 
TRP   CA    C      sing N N 404 
TRP   CA    CB     sing N N 405 
TRP   CA    HA     sing N N 406 
TRP   C     O      doub N N 407 
TRP   C     OXT    sing N N 408 
TRP   CB    CG     sing N N 409 
TRP   CB    HB2    sing N N 410 
TRP   CB    HB3    sing N N 411 
TRP   CG    CD1    doub Y N 412 
TRP   CG    CD2    sing Y N 413 
TRP   CD1   NE1    sing Y N 414 
TRP   CD1   HD1    sing N N 415 
TRP   CD2   CE2    doub Y N 416 
TRP   CD2   CE3    sing Y N 417 
TRP   NE1   CE2    sing Y N 418 
TRP   NE1   HE1    sing N N 419 
TRP   CE2   CZ2    sing Y N 420 
TRP   CE3   CZ3    doub Y N 421 
TRP   CE3   HE3    sing N N 422 
TRP   CZ2   CH2    doub Y N 423 
TRP   CZ2   HZ2    sing N N 424 
TRP   CZ3   CH2    sing Y N 425 
TRP   CZ3   HZ3    sing N N 426 
TRP   CH2   HH2    sing N N 427 
TRP   OXT   HXT    sing N N 428 
TYR   N     CA     sing N N 429 
TYR   N     H      sing N N 430 
TYR   N     H2     sing N N 431 
TYR   CA    C      sing N N 432 
TYR   CA    CB     sing N N 433 
TYR   CA    HA     sing N N 434 
TYR   C     O      doub N N 435 
TYR   C     OXT    sing N N 436 
TYR   CB    CG     sing N N 437 
TYR   CB    HB2    sing N N 438 
TYR   CB    HB3    sing N N 439 
TYR   CG    CD1    doub Y N 440 
TYR   CG    CD2    sing Y N 441 
TYR   CD1   CE1    sing Y N 442 
TYR   CD1   HD1    sing N N 443 
TYR   CD2   CE2    doub Y N 444 
TYR   CD2   HD2    sing N N 445 
TYR   CE1   CZ     doub Y N 446 
TYR   CE1   HE1    sing N N 447 
TYR   CE2   CZ     sing Y N 448 
TYR   CE2   HE2    sing N N 449 
TYR   CZ    OH     sing N N 450 
TYR   OH    HH     sing N N 451 
TYR   OXT   HXT    sing N N 452 
VAL   N     CA     sing N N 453 
VAL   N     H      sing N N 454 
VAL   N     H2     sing N N 455 
VAL   CA    C      sing N N 456 
VAL   CA    CB     sing N N 457 
VAL   CA    HA     sing N N 458 
VAL   C     O      doub N N 459 
VAL   C     OXT    sing N N 460 
VAL   CB    CG1    sing N N 461 
VAL   CB    CG2    sing N N 462 
VAL   CB    HB     sing N N 463 
VAL   CG1   HG11   sing N N 464 
VAL   CG1   HG12   sing N N 465 
VAL   CG1   HG13   sing N N 466 
VAL   CG2   HG21   sing N N 467 
VAL   CG2   HG22   sing N N 468 
VAL   CG2   HG23   sing N N 469 
VAL   OXT   HXT    sing N N 470 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-12-11 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9MGY 
_em_admin.last_update        2025-02-26 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Cryo-EM structure of Human NLRP3 complex with compound 1' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         52.34 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9MGY 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
F 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . LYS   A 1 133  ? 83.539  124.058 147.787 1.00 117.14 ?  133  LYS   C N     1 
ATOM   2    C CA    . LYS   A 1 133  ? 82.377  124.605 147.093 1.00 127.47 ?  133  LYS   C CA    1 
ATOM   3    C C     . LYS   A 1 133  ? 82.813  125.676 146.080 1.00 112.13 ?  133  LYS   C C     1 
ATOM   4    O O     . LYS   A 1 133  ? 82.845  125.415 144.874 1.00 123.34 ?  133  LYS   C O     1 
ATOM   5    C CB    . LYS   A 1 133  ? 81.347  125.157 148.109 1.00 130.76 ?  133  LYS   C CB    1 
ATOM   6    C CG    . LYS   A 1 133  ? 80.618  124.072 148.959 1.00 141.24 ?  133  LYS   C CG    1 
ATOM   7    C CD    . LYS   A 1 133  ? 79.623  124.701 149.980 1.00 151.73 ?  133  LYS   C CD    1 
ATOM   8    C CE    . LYS   A 1 133  ? 78.908  123.622 150.833 1.00 152.48 ?  133  LYS   C CE    1 
ATOM   9    N NZ    . LYS   A 1 133  ? 77.997  124.221 151.852 1.00 151.66 1  133  LYS   C NZ    1 
ATOM   10   N N     . LYS   A 1 134  ? 83.152  126.876 146.581 1.00 128.77 ?  134  LYS   C N     1 
ATOM   11   C CA    . LYS   A 1 134  ? 83.637  127.997 145.771 1.00 129.94 ?  134  LYS   C CA    1 
ATOM   12   C C     . LYS   A 1 134  ? 85.112  128.226 146.047 1.00 92.24  ?  134  LYS   C C     1 
ATOM   13   O O     . LYS   A 1 134  ? 85.617  127.852 147.106 1.00 89.75  ?  134  LYS   C O     1 
ATOM   14   C CB    . LYS   A 1 134  ? 82.846  129.273 146.069 1.00 111.77 ?  134  LYS   C CB    1 
ATOM   15   C CG    . LYS   A 1 134  ? 81.382  129.221 145.658 1.00 122.61 ?  134  LYS   C CG    1 
ATOM   16   C CD    . LYS   A 1 134  ? 80.686  130.556 145.909 1.00 133.07 ?  134  LYS   C CD    1 
ATOM   17   C CE    . LYS   A 1 134  ? 79.227  130.519 145.453 1.00 138.48 ?  134  LYS   C CE    1 
ATOM   18   N NZ    . LYS   A 1 134  ? 78.534  131.813 145.694 1.00 140.45 1  134  LYS   C NZ    1 
ATOM   19   N N     . ASP   A 1 135  ? 85.803  128.851 145.101 1.00 92.10  ?  135  ASP   C N     1 
ATOM   20   C CA    . ASP   A 1 135  ? 87.216  129.152 145.290 1.00 86.46  ?  135  ASP   C CA    1 
ATOM   21   C C     . ASP   A 1 135  ? 87.383  130.488 146.003 1.00 75.03  ?  135  ASP   C C     1 
ATOM   22   O O     . ASP   A 1 135  ? 87.170  131.554 145.424 1.00 72.17  ?  135  ASP   C O     1 
ATOM   23   C CB    . ASP   A 1 135  ? 87.962  129.152 143.955 1.00 83.77  ?  135  ASP   C CB    1 
ATOM   24   C CG    . ASP   A 1 135  ? 89.471  129.280 144.126 1.00 78.26  ?  135  ASP   C CG    1 
ATOM   25   O OD1   . ASP   A 1 135  ? 89.908  129.739 145.160 1.00 74.37  ?  135  ASP   C OD1   1 
ATOM   26   O OD2   . ASP   A 1 135  ? 90.183  128.905 143.227 1.00 69.47  -1 135  ASP   C OD2   1 
ATOM   27   N N     . TYR   A 1 136  ? 87.739  130.413 147.276 1.00 73.50  ?  136  TYR   C N     1 
ATOM   28   C CA    . TYR   A 1 136  ? 87.825  131.565 148.166 1.00 74.82  ?  136  TYR   C CA    1 
ATOM   29   C C     . TYR   A 1 136  ? 88.868  132.581 147.716 1.00 67.13  ?  136  TYR   C C     1 
ATOM   30   O O     . TYR   A 1 136  ? 88.855  133.731 148.163 1.00 63.43  ?  136  TYR   C O     1 
ATOM   31   C CB    . TYR   A 1 136  ? 88.124  131.090 149.587 1.00 78.08  ?  136  TYR   C CB    1 
ATOM   32   C CG    . TYR   A 1 136  ? 89.470  130.414 149.718 1.00 79.01  ?  136  TYR   C CG    1 
ATOM   33   C CD1   . TYR   A 1 136  ? 90.591  131.156 150.038 1.00 76.08  ?  136  TYR   C CD1   1 
ATOM   34   C CD2   . TYR   A 1 136  ? 89.580  129.045 149.504 1.00 80.54  ?  136  TYR   C CD2   1 
ATOM   35   C CE1   . TYR   A 1 136  ? 91.813  130.538 150.143 1.00 77.00  ?  136  TYR   C CE1   1 
ATOM   36   C CE2   . TYR   A 1 136  ? 90.806  128.425 149.611 1.00 81.76  ?  136  TYR   C CE2   1 
ATOM   37   C CZ    . TYR   A 1 136  ? 91.919  129.168 149.927 1.00 79.95  ?  136  TYR   C CZ    1 
ATOM   38   O OH    . TYR   A 1 136  ? 93.149  128.562 150.026 1.00 77.32  ?  136  TYR   C OH    1 
ATOM   39   N N     . ARG   A 1 137  ? 89.773  132.158 146.841 1.00 68.92  ?  137  ARG   C N     1 
ATOM   40   C CA    . ARG   A 1 137  ? 90.813  133.043 146.352 1.00 62.81  ?  137  ARG   C CA    1 
ATOM   41   C C     . ARG   A 1 137  ? 90.213  134.142 145.492 1.00 58.20  ?  137  ARG   C C     1 
ATOM   42   O O     . ARG   A 1 137  ? 90.822  135.197 145.307 1.00 57.01  ?  137  ARG   C O     1 
ATOM   43   C CB    . ARG   A 1 137  ? 91.833  132.276 145.535 1.00 58.42  ?  137  ARG   C CB    1 
ATOM   44   C CG    . ARG   A 1 137  ? 92.639  131.265 146.317 1.00 63.88  ?  137  ARG   C CG    1 
ATOM   45   C CD    . ARG   A 1 137  ? 93.626  130.569 145.457 1.00 63.43  ?  137  ARG   C CD    1 
ATOM   46   N NE    . ARG   A 1 137  ? 92.978  129.759 144.441 1.00 71.12  ?  137  ARG   C NE    1 
ATOM   47   C CZ    . ARG   A 1 137  ? 93.604  129.127 143.435 1.00 59.38  ?  137  ARG   C CZ    1 
ATOM   48   N NH1   . ARG   A 1 137  ? 94.909  129.203 143.302 1.00 57.28  1  137  ARG   C NH1   1 
ATOM   49   N NH2   . ARG   A 1 137  ? 92.889  128.429 142.582 1.00 60.17  ?  137  ARG   C NH2   1 
ATOM   50   N N     . LYS   A 1 138  ? 89.022  133.890 144.954 1.00 63.41  ?  138  LYS   C N     1 
ATOM   51   C CA    . LYS   A 1 138  ? 88.348  134.876 144.128 1.00 57.90  ?  138  LYS   C CA    1 
ATOM   52   C C     . LYS   A 1 138  ? 87.856  136.019 144.993 1.00 56.60  ?  138  LYS   C C     1 
ATOM   53   O O     . LYS   A 1 138  ? 87.913  137.181 144.593 1.00 56.62  ?  138  LYS   C O     1 
ATOM   54   C CB    . LYS   A 1 138  ? 87.183  134.245 143.368 1.00 72.89  ?  138  LYS   C CB    1 
ATOM   55   C CG    . LYS   A 1 138  ? 87.601  133.285 142.259 1.00 79.17  ?  138  LYS   C CG    1 
ATOM   56   C CD    . LYS   A 1 138  ? 86.394  132.687 141.555 1.00 77.16  ?  138  LYS   C CD    1 
ATOM   57   C CE    . LYS   A 1 138  ? 86.818  131.738 140.442 1.00 86.18  ?  138  LYS   C CE    1 
ATOM   58   N NZ    . LYS   A 1 138  ? 85.645  131.133 139.747 1.00 100.32 1  138  LYS   C NZ    1 
ATOM   59   N N     . LYS   A 1 139  ? 87.385  135.686 146.191 1.00 59.57  ?  139  LYS   C N     1 
ATOM   60   C CA    . LYS   A 1 139  ? 86.892  136.693 147.115 1.00 58.11  ?  139  LYS   C CA    1 
ATOM   61   C C     . LYS   A 1 139  ? 88.045  137.544 147.598 1.00 57.11  ?  139  LYS   C C     1 
ATOM   62   O O     . LYS   A 1 139  ? 87.907  138.755 147.769 1.00 57.59  ?  139  LYS   C O     1 
ATOM   63   C CB    . LYS   A 1 139  ? 86.173  136.050 148.301 1.00 65.98  ?  139  LYS   C CB    1 
ATOM   64   C CG    . LYS   A 1 139  ? 85.579  137.047 149.314 1.00 66.43  ?  139  LYS   C CG    1 
ATOM   65   C CD    . LYS   A 1 139  ? 84.438  137.873 148.708 1.00 74.60  ?  139  LYS   C CD    1 
ATOM   66   C CE    . LYS   A 1 139  ? 83.756  138.740 149.762 1.00 47.51  ?  139  LYS   C CE    1 
ATOM   67   N NZ    . LYS   A 1 139  ? 82.693  139.602 149.172 1.00 10.66  1  139  LYS   C NZ    1 
ATOM   68   N N     . TYR   A 1 140  ? 89.190  136.906 147.816 1.00 58.24  ?  140  TYR   C N     1 
ATOM   69   C CA    . TYR   A 1 140  ? 90.362  137.636 148.258 1.00 53.00  ?  140  TYR   C CA    1 
ATOM   70   C C     . TYR   A 1 140  ? 90.794  138.626 147.192 1.00 48.32  ?  140  TYR   C C     1 
ATOM   71   O O     . TYR   A 1 140  ? 91.066  139.785 147.497 1.00 51.81  ?  140  TYR   C O     1 
ATOM   72   C CB    . TYR   A 1 140  ? 91.498  136.685 148.629 1.00 51.42  ?  140  TYR   C CB    1 
ATOM   73   C CG    . TYR   A 1 140  ? 92.725  137.406 149.132 1.00 53.76  ?  140  TYR   C CG    1 
ATOM   74   C CD1   . TYR   A 1 140  ? 92.603  138.340 150.152 1.00 56.98  ?  140  TYR   C CD1   1 
ATOM   75   C CD2   . TYR   A 1 140  ? 93.976  137.136 148.589 1.00 53.39  ?  140  TYR   C CD2   1 
ATOM   76   C CE1   . TYR   A 1 140  ? 93.708  139.000 150.611 1.00 55.16  ?  140  TYR   C CE1   1 
ATOM   77   C CE2   . TYR   A 1 140  ? 95.090  137.806 149.066 1.00 48.96  ?  140  TYR   C CE2   1 
ATOM   78   C CZ    . TYR   A 1 140  ? 94.947  138.736 150.077 1.00 48.86  ?  140  TYR   C CZ    1 
ATOM   79   O OH    . TYR   A 1 140  ? 96.035  139.411 150.570 1.00 47.25  ?  140  TYR   C OH    1 
ATOM   80   N N     . ARG   A 1 141  ? 90.830  138.189 145.939 1.00 46.27  ?  141  ARG   C N     1 
ATOM   81   C CA    . ARG   A 1 141  ? 91.185  139.098 144.861 1.00 45.61  ?  141  ARG   C CA    1 
ATOM   82   C C     . ARG   A 1 141  ? 90.189  140.252 144.771 1.00 45.73  ?  141  ARG   C C     1 
ATOM   83   O O     . ARG   A 1 141  ? 90.587  141.395 144.550 1.00 47.28  ?  141  ARG   C O     1 
ATOM   84   C CB    . ARG   A 1 141  ? 91.257  138.358 143.540 1.00 43.15  ?  141  ARG   C CB    1 
ATOM   85   C CG    . ARG   A 1 141  ? 92.464  137.443 143.400 1.00 40.37  ?  141  ARG   C CG    1 
ATOM   86   C CD    . ARG   A 1 141  ? 92.393  136.630 142.168 1.00 43.89  ?  141  ARG   C CD    1 
ATOM   87   N NE    . ARG   A 1 141  ? 93.483  135.667 142.087 1.00 44.25  ?  141  ARG   C NE    1 
ATOM   88   C CZ    . ARG   A 1 141  ? 94.671  135.875 141.481 1.00 45.48  ?  141  ARG   C CZ    1 
ATOM   89   N NH1   . ARG   A 1 141  ? 94.935  137.018 140.883 1.00 41.48  1  141  ARG   C NH1   1 
ATOM   90   N NH2   . ARG   A 1 141  ? 95.575  134.910 141.483 1.00 45.97  ?  141  ARG   C NH2   1 
ATOM   91   N N     . LYS   A 1 142  ? 88.901  139.966 144.970 1.00 50.73  ?  142  LYS   C N     1 
ATOM   92   C CA    . LYS   A 1 142  ? 87.895  141.026 144.967 1.00 50.28  ?  142  LYS   C CA    1 
ATOM   93   C C     . LYS   A 1 142  ? 88.166  142.021 146.086 1.00 48.19  ?  142  LYS   C C     1 
ATOM   94   O O     . LYS   A 1 142  ? 88.101  143.234 145.878 1.00 47.03  ?  142  LYS   C O     1 
ATOM   95   C CB    . LYS   A 1 142  ? 86.485  140.450 145.124 1.00 56.99  ?  142  LYS   C CB    1 
ATOM   96   C CG    . LYS   A 1 142  ? 85.935  139.733 143.897 1.00 60.66  ?  142  LYS   C CG    1 
ATOM   97   C CD    . LYS   A 1 142  ? 84.559  139.124 144.180 1.00 69.49  ?  142  LYS   C CD    1 
ATOM   98   C CE    . LYS   A 1 142  ? 84.017  138.378 142.968 1.00 69.54  ?  142  LYS   C CE    1 
ATOM   99   N NZ    . LYS   A 1 142  ? 82.682  137.776 143.240 1.00 65.37  1  142  LYS   C NZ    1 
ATOM   100  N N     . TYR   A 1 143  ? 88.499  141.499 147.264 1.00 48.93  ?  143  TYR   C N     1 
ATOM   101  C CA    . TYR   A 1 143  ? 88.835  142.326 148.414 1.00 49.46  ?  143  TYR   C CA    1 
ATOM   102  C C     . TYR   A 1 143  ? 90.028  143.220 148.111 1.00 50.59  ?  143  TYR   C C     1 
ATOM   103  O O     . TYR   A 1 143  ? 90.006  144.420 148.391 1.00 45.48  ?  143  TYR   C O     1 
ATOM   104  C CB    . TYR   A 1 143  ? 89.103  141.448 149.640 1.00 52.23  ?  143  TYR   C CB    1 
ATOM   105  C CG    . TYR   A 1 143  ? 89.600  142.215 150.830 1.00 58.62  ?  143  TYR   C CG    1 
ATOM   106  C CD1   . TYR   A 1 143  ? 88.751  143.084 151.495 1.00 62.10  ?  143  TYR   C CD1   1 
ATOM   107  C CD2   . TYR   A 1 143  ? 90.902  142.048 151.261 1.00 58.92  ?  143  TYR   C CD2   1 
ATOM   108  C CE1   . TYR   A 1 143  ? 89.207  143.798 152.585 1.00 62.31  ?  143  TYR   C CE1   1 
ATOM   109  C CE2   . TYR   A 1 143  ? 91.358  142.758 152.352 1.00 61.00  ?  143  TYR   C CE2   1 
ATOM   110  C CZ    . TYR   A 1 143  ? 90.515  143.635 153.012 1.00 63.33  ?  143  TYR   C CZ    1 
ATOM   111  O OH    . TYR   A 1 143  ? 90.982  144.350 154.098 1.00 65.50  ?  143  TYR   C OH    1 
ATOM   112  N N     . VAL   A 1 144  ? 91.070  142.639 147.534 1.00 46.78  ?  144  VAL   C N     1 
ATOM   113  C CA    . VAL   A 1 144  ? 92.259  143.397 147.200 1.00 42.17  ?  144  VAL   C CA    1 
ATOM   114  C C     . VAL   A 1 144  ? 91.937  144.487 146.186 1.00 40.52  ?  144  VAL   C C     1 
ATOM   115  O O     . VAL   A 1 144  ? 92.389  145.622 146.330 1.00 42.17  ?  144  VAL   C O     1 
ATOM   116  C CB    . VAL   A 1 144  ? 93.352  142.464 146.647 1.00 40.54  ?  144  VAL   C CB    1 
ATOM   117  C CG1   . VAL   A 1 144  ? 94.525  143.275 146.098 1.00 40.32  ?  144  VAL   C CG1   1 
ATOM   118  C CG2   . VAL   A 1 144  ? 93.835  141.537 147.758 1.00 40.03  ?  144  VAL   C CG2   1 
ATOM   119  N N     . ARG   A 1 145  ? 91.158  144.162 145.159 1.00 42.20  ?  145  ARG   C N     1 
ATOM   120  C CA    . ARG   A 1 145  ? 90.835  145.169 144.157 1.00 43.06  ?  145  ARG   C CA    1 
ATOM   121  C C     . ARG   A 1 145  ? 90.056  146.338 144.743 1.00 42.94  ?  145  ARG   C C     1 
ATOM   122  O O     . ARG   A 1 145  ? 90.300  147.487 144.377 1.00 44.02  ?  145  ARG   C O     1 
ATOM   123  C CB    . ARG   A 1 145  ? 90.032  144.589 143.003 1.00 47.41  ?  145  ARG   C CB    1 
ATOM   124  C CG    . ARG   A 1 145  ? 90.807  143.686 142.063 1.00 46.76  ?  145  ARG   C CG    1 
ATOM   125  C CD    . ARG   A 1 145  ? 90.099  143.490 140.771 1.00 52.00  ?  145  ARG   C CD    1 
ATOM   126  N NE    . ARG   A 1 145  ? 88.821  142.818 140.923 1.00 53.90  ?  145  ARG   C NE    1 
ATOM   127  C CZ    . ARG   A 1 145  ? 88.630  141.481 140.882 1.00 53.33  ?  145  ARG   C CZ    1 
ATOM   128  N NH1   . ARG   A 1 145  ? 89.637  140.649 140.694 1.00 48.95  1  145  ARG   C NH1   1 
ATOM   129  N NH2   . ARG   A 1 145  ? 87.412  141.000 141.029 1.00 55.36  ?  145  ARG   C NH2   1 
ATOM   130  N N     . SER   A 1 146  ? 89.120  146.060 145.645 1.00 44.57  ?  146  SER   C N     1 
ATOM   131  C CA    . SER   A 1 146  ? 88.324  147.131 146.228 1.00 48.09  ?  146  SER   C CA    1 
ATOM   132  C C     . SER   A 1 146  ? 89.102  147.925 147.271 1.00 47.58  ?  146  SER   C C     1 
ATOM   133  O O     . SER   A 1 146  ? 88.802  149.096 147.518 1.00 48.42  ?  146  SER   C O     1 
ATOM   134  C CB    . SER   A 1 146  ? 87.063  146.572 146.856 1.00 50.71  ?  146  SER   C CB    1 
ATOM   135  O OG    . SER   A 1 146  ? 87.356  145.832 148.007 1.00 46.95  ?  146  SER   C OG    1 
ATOM   136  N N     . ARG   A 1 147  ? 90.116  147.302 147.868 1.00 45.08  ?  147  ARG   C N     1 
ATOM   137  C CA    . ARG   A 1 147  ? 90.916  147.957 148.891 1.00 44.08  ?  147  ARG   C CA    1 
ATOM   138  C C     . ARG   A 1 147  ? 92.036  148.808 148.311 1.00 40.55  ?  147  ARG   C C     1 
ATOM   139  O O     . ARG   A 1 147  ? 92.302  149.909 148.788 1.00 42.36  ?  147  ARG   C O     1 
ATOM   140  C CB    . ARG   A 1 147  ? 91.525  146.924 149.825 1.00 43.19  ?  147  ARG   C CB    1 
ATOM   141  C CG    . ARG   A 1 147  ? 92.374  147.506 150.934 1.00 50.19  ?  147  ARG   C CG    1 
ATOM   142  C CD    . ARG   A 1 147  ? 92.883  146.469 151.852 1.00 53.97  ?  147  ARG   C CD    1 
ATOM   143  N NE    . ARG   A 1 147  ? 93.823  147.031 152.806 1.00 55.23  ?  147  ARG   C NE    1 
ATOM   144  C CZ    . ARG   A 1 147  ? 94.678  146.318 153.568 1.00 65.07  ?  147  ARG   C CZ    1 
ATOM   145  N NH1   . ARG   A 1 147  ? 94.709  145.002 153.490 1.00 63.45  1  147  ARG   C NH1   1 
ATOM   146  N NH2   . ARG   A 1 147  ? 95.492  146.949 154.398 1.00 68.71  ?  147  ARG   C NH2   1 
ATOM   147  N N     . PHE   A 1 148  ? 92.701  148.305 147.282 1.00 38.80  ?  148  PHE   C N     1 
ATOM   148  C CA    . PHE   A 1 148  ? 93.879  148.977 146.752 1.00 34.27  ?  148  PHE   C CA    1 
ATOM   149  C C     . PHE   A 1 148  ? 93.590  149.830 145.519 1.00 37.25  ?  148  PHE   C C     1 
ATOM   150  O O     . PHE   A 1 148  ? 94.513  150.271 144.837 1.00 40.98  ?  148  PHE   C O     1 
ATOM   151  C CB    . PHE   A 1 148  ? 94.960  147.944 146.440 1.00 32.83  ?  148  PHE   C CB    1 
ATOM   152  C CG    . PHE   A 1 148  ? 95.558  147.297 147.675 1.00 33.41  ?  148  PHE   C CG    1 
ATOM   153  C CD1   . PHE   A 1 148  ? 95.008  146.158 148.212 1.00 35.19  ?  148  PHE   C CD1   1 
ATOM   154  C CD2   . PHE   A 1 148  ? 96.676  147.828 148.285 1.00 32.49  ?  148  PHE   C CD2   1 
ATOM   155  C CE1   . PHE   A 1 148  ? 95.549  145.558 149.323 1.00 36.06  ?  148  PHE   C CE1   1 
ATOM   156  C CE2   . PHE   A 1 148  ? 97.225  147.233 149.402 1.00 32.94  ?  148  PHE   C CE2   1 
ATOM   157  C CZ    . PHE   A 1 148  ? 96.659  146.094 149.919 1.00 35.94  ?  148  PHE   C CZ    1 
ATOM   158  N N     . GLN   A 1 149  ? 92.314  150.087 145.247 1.00 40.13  ?  149  GLN   C N     1 
ATOM   159  C CA    . GLN   A 1 149  ? 91.927  150.930 144.116 1.00 42.75  ?  149  GLN   C CA    1 
ATOM   160  C C     . GLN   A 1 149  ? 92.263  152.396 144.364 1.00 43.04  ?  149  GLN   C C     1 
ATOM   161  O O     . GLN   A 1 149  ? 92.300  153.202 143.431 1.00 47.01  ?  149  GLN   C O     1 
ATOM   162  C CB    . GLN   A 1 149  ? 90.432  150.807 143.829 1.00 51.44  ?  149  GLN   C CB    1 
ATOM   163  C CG    . GLN   A 1 149  ? 89.550  151.441 144.882 1.00 55.64  ?  149  GLN   C CG    1 
ATOM   164  C CD    . GLN   A 1 149  ? 88.078  151.291 144.583 1.00 57.96  ?  149  GLN   C CD    1 
ATOM   165  O OE1   . GLN   A 1 149  ? 87.582  151.794 143.570 1.00 54.60  ?  149  GLN   C OE1   1 
ATOM   166  N NE2   . GLN   A 1 149  ? 87.365  150.598 145.462 1.00 62.76  ?  149  GLN   C NE2   1 
ATOM   167  N N     . CYS   A 1 150  ? 92.470  152.745 145.629 1.00 44.32  ?  150  CYS   C N     1 
ATOM   168  C CA    . CYS   A 1 150  ? 92.794  154.110 146.026 1.00 50.13  ?  150  CYS   C CA    1 
ATOM   169  C C     . CYS   A 1 150  ? 94.243  154.224 146.477 1.00 52.02  ?  150  CYS   C C     1 
ATOM   170  O O     . CYS   A 1 150  ? 94.839  153.248 146.936 1.00 47.68  ?  150  CYS   C O     1 
ATOM   171  C CB    . CYS   A 1 150  ? 91.866  154.585 147.140 1.00 53.97  ?  150  CYS   C CB    1 
ATOM   172  S SG    . CYS   A 1 150  ? 90.145  154.748 146.640 1.00 62.84  ?  150  CYS   C SG    1 
ATOM   173  N N     . ILE   A 1 151  ? 94.810  155.418 146.370 1.00 51.60  ?  151  ILE   C N     1 
ATOM   174  C CA    . ILE   A 1 151  ? 96.205  155.646 146.725 1.00 53.11  ?  151  ILE   C CA    1 
ATOM   175  C C     . ILE   A 1 151  ? 96.544  155.374 148.198 1.00 52.00  ?  151  ILE   C C     1 
ATOM   176  O O     . ILE   A 1 151  ? 97.578  154.780 148.491 1.00 46.62  ?  151  ILE   C O     1 
ATOM   177  C CB    . ILE   A 1 151  ? 96.617  157.101 146.385 1.00 53.29  ?  151  ILE   C CB    1 
ATOM   178  C CG1   . ILE   A 1 151  ? 96.580  157.348 144.852 1.00 52.27  ?  151  ILE   C CG1   1 
ATOM   179  C CG2   . ILE   A 1 151  ? 97.992  157.420 146.953 1.00 55.30  ?  151  ILE   C CG2   1 
ATOM   180  C CD1   . ILE   A 1 151  ? 97.618  156.593 144.052 1.00 49.42  ?  151  ILE   C CD1   1 
ATOM   181  N N     . GLU   A 1 152  ? 95.706  155.855 149.117 1.00 54.21  ?  152  GLU   C N     1 
ATOM   182  C CA    . GLU   A 1 152  ? 96.059  155.799 150.536 1.00 56.54  ?  152  GLU   C CA    1 
ATOM   183  C C     . GLU   A 1 152  ? 95.409  154.682 151.361 1.00 53.74  ?  152  GLU   C C     1 
ATOM   184  O O     . GLU   A 1 152  ? 96.000  154.229 152.341 1.00 54.74  ?  152  GLU   C O     1 
ATOM   185  C CB    . GLU   A 1 152  ? 95.704  157.137 151.189 1.00 60.17  ?  152  GLU   C CB    1 
ATOM   186  C CG    . GLU   A 1 152  ? 96.410  158.344 150.594 1.00 59.29  ?  152  GLU   C CG    1 
ATOM   187  C CD    . GLU   A 1 152  ? 95.753  158.849 149.342 1.00 61.22  ?  152  GLU   C CD    1 
ATOM   188  O OE1   . GLU   A 1 152  ? 94.835  158.208 148.870 1.00 59.09  ?  152  GLU   C OE1   1 
ATOM   189  O OE2   . GLU   A 1 152  ? 96.157  159.878 148.858 1.00 65.56  -1 152  GLU   C OE2   1 
ATOM   190  N N     . ASP   A 1 153  ? 94.184  154.282 151.014 1.00 54.49  ?  153  ASP   C N     1 
ATOM   191  C CA    . ASP   A 1 153  ? 93.377  153.385 151.860 1.00 60.37  ?  153  ASP   C CA    1 
ATOM   192  C C     . ASP   A 1 153  ? 93.035  154.086 153.171 1.00 65.93  ?  153  ASP   C C     1 
ATOM   193  O O     . ASP   A 1 153  ? 92.758  153.455 154.194 1.00 64.85  ?  153  ASP   C O     1 
ATOM   194  C CB    . ASP   A 1 153  ? 94.127  152.083 152.170 1.00 60.78  ?  153  ASP   C CB    1 
ATOM   195  C CG    . ASP   A 1 153  ? 93.216  150.904 152.561 1.00 64.22  ?  153  ASP   C CG    1 
ATOM   196  O OD1   . ASP   A 1 153  ? 92.062  150.908 152.194 1.00 65.53  ?  153  ASP   C OD1   1 
ATOM   197  O OD2   . ASP   A 1 153  ? 93.708  150.000 153.212 1.00 61.40  -1 153  ASP   C OD2   1 
ATOM   198  N N     . ARG   A 1 154  ? 93.064  155.407 153.111 1.00 64.62  ?  154  ARG   C N     1 
ATOM   199  C CA    . ARG   A 1 154  ? 92.813  156.269 154.243 1.00 61.37  ?  154  ARG   C CA    1 
ATOM   200  C C     . ARG   A 1 154  ? 91.972  157.462 153.827 1.00 63.98  ?  154  ARG   C C     1 
ATOM   201  O O     . ARG   A 1 154  ? 91.956  157.834 152.655 1.00 66.94  ?  154  ARG   C O     1 
ATOM   202  C CB    . ARG   A 1 154  ? 94.129  156.752 154.824 1.00 61.19  ?  154  ARG   C CB    1 
ATOM   203  C CG    . ARG   A 1 154  ? 95.054  155.638 155.334 1.00 62.11  ?  154  ARG   C CG    1 
ATOM   204  C CD    . ARG   A 1 154  ? 96.346  156.147 155.829 1.00 60.24  ?  154  ARG   C CD    1 
ATOM   205  N NE    . ARG   A 1 154  ? 96.995  155.200 156.700 1.00 63.68  ?  154  ARG   C NE    1 
ATOM   206  C CZ    . ARG   A 1 154  ? 98.132  155.426 157.389 1.00 62.66  ?  154  ARG   C CZ    1 
ATOM   207  N NH1   . ARG   A 1 154  ? 98.772  156.577 157.277 1.00 57.74  1  154  ARG   C NH1   1 
ATOM   208  N NH2   . ARG   A 1 154  ? 98.597  154.480 158.189 1.00 59.66  ?  154  ARG   C NH2   1 
ATOM   209  N N     . ASN   A 1 155  ? 91.294  158.064 154.795 1.00 63.56  ?  155  ASN   C N     1 
ATOM   210  C CA    . ASN   A 1 155  ? 90.486  159.259 154.594 1.00 63.69  ?  155  ASN   C CA    1 
ATOM   211  C C     . ASN   A 1 155  ? 91.314  160.522 154.718 1.00 64.02  ?  155  ASN   C C     1 
ATOM   212  O O     . ASN   A 1 155  ? 92.540  160.487 154.628 1.00 62.25  ?  155  ASN   C O     1 
ATOM   213  C CB    . ASN   A 1 155  ? 89.334  159.304 155.576 1.00 62.38  ?  155  ASN   C CB    1 
ATOM   214  C CG    . ASN   A 1 155  ? 89.794  159.375 156.988 1.00 65.45  ?  155  ASN   C CG    1 
ATOM   215  O OD1   . ASN   A 1 155  ? 91.006  159.461 157.262 1.00 66.43  ?  155  ASN   C OD1   1 
ATOM   216  N ND2   . ASN   A 1 155  ? 88.856  159.351 157.897 1.00 66.01  ?  155  ASN   C ND2   1 
ATOM   217  N N     . ALA   A 1 156  ? 90.620  161.645 154.894 1.00 68.69  ?  156  ALA   C N     1 
ATOM   218  C CA    . ALA   A 1 156  ? 91.239  162.956 155.032 1.00 67.13  ?  156  ALA   C CA    1 
ATOM   219  C C     . ALA   A 1 156  ? 92.043  163.341 153.803 1.00 66.51  ?  156  ALA   C C     1 
ATOM   220  O O     . ALA   A 1 156  ? 93.031  164.070 153.902 1.00 62.61  ?  156  ALA   C O     1 
ATOM   221  C CB    . ALA   A 1 156  ? 92.131  162.975 156.261 1.00 67.29  ?  156  ALA   C CB    1 
ATOM   222  N N     . ARG   A 1 157  ? 91.594  162.907 152.631 1.00 72.29  ?  157  ARG   C N     1 
ATOM   223  C CA    . ARG   A 1 157  ? 92.282  163.265 151.400 1.00 73.15  ?  157  ARG   C CA    1 
ATOM   224  C C     . ARG   A 1 157  ? 91.728  164.580 150.869 1.00 87.42  ?  157  ARG   C C     1 
ATOM   225  O O     . ARG   A 1 157  ? 91.114  164.628 149.801 1.00 73.27  ?  157  ARG   C O     1 
ATOM   226  C CB    . ARG   A 1 157  ? 92.112  162.175 150.353 1.00 72.10  ?  157  ARG   C CB    1 
ATOM   227  C CG    . ARG   A 1 157  ? 92.583  160.800 150.789 1.00 65.31  ?  157  ARG   C CG    1 
ATOM   228  C CD    . ARG   A 1 157  ? 92.499  159.827 149.687 1.00 64.30  ?  157  ARG   C CD    1 
ATOM   229  N NE    . ARG   A 1 157  ? 91.141  159.689 149.159 1.00 68.82  ?  157  ARG   C NE    1 
ATOM   230  C CZ    . ARG   A 1 157  ? 90.188  158.859 149.632 1.00 65.69  ?  157  ARG   C CZ    1 
ATOM   231  N NH1   . ARG   A 1 157  ? 90.415  158.087 150.659 1.00 61.82  1  157  ARG   C NH1   1 
ATOM   232  N NH2   . ARG   A 1 157  ? 89.010  158.832 149.044 1.00 68.69  ?  157  ARG   C NH2   1 
ATOM   233  N N     . LEU   A 1 158  ? 91.933  165.644 151.644 1.00 77.97  ?  158  LEU   C N     1 
ATOM   234  C CA    . LEU   A 1 158  ? 91.454  166.980 151.290 1.00 82.88  ?  158  LEU   C CA    1 
ATOM   235  C C     . LEU   A 1 158  ? 89.971  166.969 150.931 1.00 93.53  ?  158  LEU   C C     1 
ATOM   236  O O     . LEU   A 1 158  ? 89.583  167.388 149.841 1.00 82.03  ?  158  LEU   C O     1 
ATOM   237  C CB    . LEU   A 1 158  ? 92.257  167.519 150.102 1.00 84.42  ?  158  LEU   C CB    1 
ATOM   238  C CG    . LEU   A 1 158  ? 93.774  167.610 150.309 1.00 77.36  ?  158  LEU   C CG    1 
ATOM   239  C CD1   . LEU   A 1 158  ? 94.438  167.918 148.980 1.00 65.89  ?  158  LEU   C CD1   1 
ATOM   240  C CD2   . LEU   A 1 158  ? 94.088  168.702 151.337 1.00 71.13  ?  158  LEU   C CD2   1 
ATOM   241  N N     . GLY   A 1 159  ? 89.144  166.461 151.842 1.00 77.90  ?  159  GLY   C N     1 
ATOM   242  C CA    . GLY   A 1 159  ? 87.715  166.317 151.577 1.00 84.97  ?  159  GLY   C CA    1 
ATOM   243  C C     . GLY   A 1 159  ? 87.387  164.895 151.142 1.00 84.69  ?  159  GLY   C C     1 
ATOM   244  O O     . GLY   A 1 159  ? 86.273  164.606 150.706 1.00 83.16  ?  159  GLY   C O     1 
ATOM   245  N N     . GLU   A 1 160  ? 88.371  164.015 151.280 1.00 79.96  ?  160  GLU   C N     1 
ATOM   246  C CA    . GLU   A 1 160  ? 88.247  162.603 150.932 1.00 68.67  ?  160  GLU   C CA    1 
ATOM   247  C C     . GLU   A 1 160  ? 87.780  162.385 149.496 1.00 84.12  ?  160  GLU   C C     1 
ATOM   248  O O     . GLU   A 1 160  ? 86.827  161.645 149.247 1.00 74.14  ?  160  GLU   C O     1 
ATOM   249  C CB    . GLU   A 1 160  ? 87.312  161.887 151.909 1.00 81.46  ?  160  GLU   C CB    1 
ATOM   250  C CG    . GLU   A 1 160  ? 87.526  160.376 151.970 1.00 75.51  ?  160  GLU   C CG    1 
ATOM   251  C CD    . GLU   A 1 160  ? 86.817  159.705 153.113 1.00 74.39  ?  160  GLU   C CD    1 
ATOM   252  O OE1   . GLU   A 1 160  ? 86.647  160.323 154.136 1.00 77.91  ?  160  GLU   C OE1   1 
ATOM   253  O OE2   . GLU   A 1 160  ? 86.457  158.562 152.963 1.00 71.32  -1 160  GLU   C OE2   1 
ATOM   254  N N     . SER   A 1 161  ? 88.477  163.010 148.549 1.00 79.87  ?  161  SER   C N     1 
ATOM   255  C CA    . SER   A 1 161  ? 88.188  162.801 147.135 1.00 76.09  ?  161  SER   C CA    1 
ATOM   256  C C     . SER   A 1 161  ? 88.704  161.432 146.726 1.00 63.28  ?  161  SER   C C     1 
ATOM   257  O O     . SER   A 1 161  ? 89.511  160.836 147.437 1.00 62.69  ?  161  SER   C O     1 
ATOM   258  C CB    . SER   A 1 161  ? 88.839  163.879 146.289 1.00 88.34  ?  161  SER   C CB    1 
ATOM   259  O OG    . SER   A 1 161  ? 90.234  163.755 146.301 1.00 76.14  ?  161  SER   C OG    1 
ATOM   260  N N     . VAL   A 1 162  ? 88.264  160.919 145.586 1.00 64.77  ?  162  VAL   C N     1 
ATOM   261  C CA    . VAL   A 1 162  ? 88.771  159.620 145.165 1.00 73.17  ?  162  VAL   C CA    1 
ATOM   262  C C     . VAL   A 1 162  ? 90.138  159.806 144.540 1.00 70.01  ?  162  VAL   C C     1 
ATOM   263  O O     . VAL   A 1 162  ? 90.283  160.523 143.551 1.00 67.98  ?  162  VAL   C O     1 
ATOM   264  C CB    . VAL   A 1 162  ? 87.817  158.938 144.165 1.00 68.15  ?  162  VAL   C CB    1 
ATOM   265  C CG1   . VAL   A 1 162  ? 88.399  157.603 143.719 1.00 63.86  ?  162  VAL   C CG1   1 
ATOM   266  C CG2   . VAL   A 1 162  ? 86.461  158.735 144.815 1.00 72.65  ?  162  VAL   C CG2   1 
ATOM   267  N N     . SER   A 1 163  ? 91.144  159.181 145.140 1.00 66.81  ?  163  SER   C N     1 
ATOM   268  C CA    . SER   A 1 163  ? 92.519  159.371 144.716 1.00 62.05  ?  163  SER   C CA    1 
ATOM   269  C C     . SER   A 1 163  ? 92.827  158.693 143.392 1.00 60.38  ?  163  SER   C C     1 
ATOM   270  O O     . SER   A 1 163  ? 93.689  159.161 142.652 1.00 56.46  ?  163  SER   C O     1 
ATOM   271  C CB    . SER   A 1 163  ? 93.444  158.864 145.793 1.00 61.83  ?  163  SER   C CB    1 
ATOM   272  O OG    . SER   A 1 163  ? 93.279  157.489 145.986 1.00 59.88  ?  163  SER   C OG    1 
ATOM   273  N N     . LEU   A 1 164  ? 92.106  157.616 143.082 1.00 58.86  ?  164  LEU   C N     1 
ATOM   274  C CA    . LEU   A 1 164  ? 92.244  156.920 141.803 1.00 56.36  ?  164  LEU   C CA    1 
ATOM   275  C C     . LEU   A 1 164  ? 93.653  156.372 141.575 1.00 51.34  ?  164  LEU   C C     1 
ATOM   276  O O     . LEU   A 1 164  ? 94.483  157.037 140.958 1.00 49.76  ?  164  LEU   C O     1 
ATOM   277  C CB    . LEU   A 1 164  ? 91.883  157.873 140.648 1.00 58.34  ?  164  LEU   C CB    1 
ATOM   278  C CG    . LEU   A 1 164  ? 90.443  158.430 140.624 1.00 66.91  ?  164  LEU   C CG    1 
ATOM   279  C CD1   . LEU   A 1 164  ? 90.346  159.494 139.543 1.00 67.47  ?  164  LEU   C CD1   1 
ATOM   280  C CD2   . LEU   A 1 164  ? 89.451  157.299 140.356 1.00 64.36  ?  164  LEU   C CD2   1 
ATOM   281  N N     . ASN   A 1 165  ? 93.918  155.146 142.032 1.00 49.23  ?  165  ASN   C N     1 
ATOM   282  C CA    . ASN   A 1 165  ? 95.252  154.552 141.903 1.00 44.31  ?  165  ASN   C CA    1 
ATOM   283  C C     . ASN   A 1 165  ? 95.660  154.336 140.448 1.00 42.13  ?  165  ASN   C C     1 
ATOM   284  O O     . ASN   A 1 165  ? 96.828  154.090 140.150 1.00 41.84  ?  165  ASN   C O     1 
ATOM   285  C CB    . ASN   A 1 165  ? 95.345  153.257 142.689 1.00 43.53  ?  165  ASN   C CB    1 
ATOM   286  C CG    . ASN   A 1 165  ? 96.762  152.745 142.834 1.00 44.77  ?  165  ASN   C CG    1 
ATOM   287  O OD1   . ASN   A 1 165  ? 97.706  153.515 143.019 1.00 40.97  ?  165  ASN   C OD1   1 
ATOM   288  N ND2   . ASN   A 1 165  ? 96.922  151.453 142.772 1.00 39.60  ?  165  ASN   C ND2   1 
ATOM   289  N N     . LYS   A 1 166  ? 94.707  154.461 139.535 1.00 44.18  ?  166  LYS   C N     1 
ATOM   290  C CA    . LYS   A 1 166  ? 94.992  154.343 138.111 1.00 42.08  ?  166  LYS   C CA    1 
ATOM   291  C C     . LYS   A 1 166  ? 95.874  155.497 137.623 1.00 43.69  ?  166  LYS   C C     1 
ATOM   292  O O     . LYS   A 1 166  ? 96.440  155.435 136.533 1.00 44.41  ?  166  LYS   C O     1 
ATOM   293  C CB    . LYS   A 1 166  ? 93.698  154.292 137.304 1.00 56.24  ?  166  LYS   C CB    1 
ATOM   294  C CG    . LYS   A 1 166  ? 92.920  155.596 137.268 1.00 58.94  ?  166  LYS   C CG    1 
ATOM   295  C CD    . LYS   A 1 166  ? 91.628  155.448 136.467 1.00 63.92  ?  166  LYS   C CD    1 
ATOM   296  C CE    . LYS   A 1 166  ? 90.901  156.778 136.341 1.00 63.53  ?  166  LYS   C CE    1 
ATOM   297  N NZ    . LYS   A 1 166  ? 89.645  156.653 135.562 1.00 72.25  1  166  LYS   C NZ    1 
ATOM   298  N N     . ARG   A 1 167  ? 95.989  156.549 138.438 1.00 44.91  ?  167  ARG   C N     1 
ATOM   299  C CA    . ARG   A 1 167  ? 96.809  157.721 138.129 1.00 43.95  ?  167  ARG   C CA    1 
ATOM   300  C C     . ARG   A 1 167  ? 98.301  157.418 138.224 1.00 36.83  ?  167  ARG   C C     1 
ATOM   301  O O     . ARG   A 1 167  ? 99.134  158.245 137.851 1.00 34.65  ?  167  ARG   C O     1 
ATOM   302  C CB    . ARG   A 1 167  ? 96.505  158.859 139.080 1.00 42.82  ?  167  ARG   C CB    1 
ATOM   303  C CG    . ARG   A 1 167  ? 97.057  158.659 140.477 1.00 41.64  ?  167  ARG   C CG    1 
ATOM   304  C CD    . ARG   A 1 167  ? 96.465  159.603 141.418 1.00 42.65  ?  167  ARG   C CD    1 
ATOM   305  N NE    . ARG   A 1 167  ? 96.937  160.950 141.223 1.00 36.60  ?  167  ARG   C NE    1 
ATOM   306  C CZ    . ARG   A 1 167  ? 96.372  162.032 141.779 1.00 41.08  ?  167  ARG   C CZ    1 
ATOM   307  N NH1   . ARG   A 1 167  ? 95.313  161.897 142.556 1.00 50.84  1  167  ARG   C NH1   1 
ATOM   308  N NH2   . ARG   A 1 167  ? 96.877  163.220 141.541 1.00 30.98  ?  167  ARG   C NH2   1 
ATOM   309  N N     . TYR   A 1 168  ? 98.635  156.258 138.777 1.00 34.00  ?  168  TYR   C N     1 
ATOM   310  C CA    . TYR   A 1 168  ? 100.018 155.860 138.969 1.00 25.45  ?  168  TYR   C CA    1 
ATOM   311  C C     . TYR   A 1 168  ? 100.909 156.294 137.822 1.00 27.56  ?  168  TYR   C C     1 
ATOM   312  O O     . TYR   A 1 168  ? 100.688 155.931 136.665 1.00 30.81  ?  168  TYR   C O     1 
ATOM   313  C CB    . TYR   A 1 168  ? 100.098 154.344 139.119 1.00 26.74  ?  168  TYR   C CB    1 
ATOM   314  C CG    . TYR   A 1 168  ? 101.498 153.796 139.171 1.00 25.90  ?  168  TYR   C CG    1 
ATOM   315  C CD1   . TYR   A 1 168  ? 102.212 153.822 140.345 1.00 27.55  ?  168  TYR   C CD1   1 
ATOM   316  C CD2   . TYR   A 1 168  ? 102.061 153.261 138.032 1.00 24.84  ?  168  TYR   C CD2   1 
ATOM   317  C CE1   . TYR   A 1 168  ? 103.492 153.308 140.382 1.00 25.99  ?  168  TYR   C CE1   1 
ATOM   318  C CE2   . TYR   A 1 168  ? 103.330 152.747 138.066 1.00 26.89  ?  168  TYR   C CE2   1 
ATOM   319  C CZ    . TYR   A 1 168  ? 104.046 152.766 139.233 1.00 25.26  ?  168  TYR   C CZ    1 
ATOM   320  O OH    . TYR   A 1 168  ? 105.317 152.247 139.262 1.00 24.58  ?  168  TYR   C OH    1 
ATOM   321  N N     . THR   A 1 169  ? 101.942 157.048 138.160 1.00 25.93  ?  169  THR   C N     1 
ATOM   322  C CA    . THR   A 1 169  ? 102.932 157.494 137.197 1.00 20.48  ?  169  THR   C CA    1 
ATOM   323  C C     . THR   A 1 169  ? 104.144 156.587 137.317 1.00 23.17  ?  169  THR   C C     1 
ATOM   324  O O     . THR   A 1 169  ? 104.621 156.326 138.420 1.00 24.62  ?  169  THR   C O     1 
ATOM   325  C CB    . THR   A 1 169  ? 103.295 158.967 137.437 1.00 18.97  ?  169  THR   C CB    1 
ATOM   326  O OG1   . THR   A 1 169  ? 102.122 159.770 137.276 1.00 21.92  ?  169  THR   C OG1   1 
ATOM   327  C CG2   . THR   A 1 169  ? 104.349 159.433 136.454 1.00 19.89  ?  169  THR   C CG2   1 
ATOM   328  N N     . ARG   A 1 170  ? 104.606 156.062 136.193 1.00 23.30  ?  170  ARG   C N     1 
ATOM   329  C CA    . ARG   A 1 170  ? 105.652 155.050 136.213 1.00 25.26  ?  170  ARG   C CA    1 
ATOM   330  C C     . ARG   A 1 170  ? 106.937 155.508 136.888 1.00 26.74  ?  170  ARG   C C     1 
ATOM   331  O O     . ARG   A 1 170  ? 107.463 156.586 136.610 1.00 25.34  ?  170  ARG   C O     1 
ATOM   332  C CB    . ARG   A 1 170  ? 105.979 154.593 134.802 1.00 25.81  ?  170  ARG   C CB    1 
ATOM   333  C CG    . ARG   A 1 170  ? 107.026 153.491 134.714 1.00 36.64  ?  170  ARG   C CG    1 
ATOM   334  C CD    . ARG   A 1 170  ? 107.248 153.045 133.316 1.00 43.68  ?  170  ARG   C CD    1 
ATOM   335  N NE    . ARG   A 1 170  ? 106.100 152.333 132.784 1.00 45.81  ?  170  ARG   C NE    1 
ATOM   336  C CZ    . ARG   A 1 170  ? 105.912 152.052 131.484 1.00 37.52  ?  170  ARG   C CZ    1 
ATOM   337  N NH1   . ARG   A 1 170  ? 106.802 152.426 130.592 1.00 38.40  1  170  ARG   C NH1   1 
ATOM   338  N NH2   . ARG   A 1 170  ? 104.829 151.399 131.104 1.00 57.99  ?  170  ARG   C NH2   1 
ATOM   339  N N     . LEU   A 1 171  ? 107.457 154.638 137.748 1.00 26.25  ?  171  LEU   C N     1 
ATOM   340  C CA    . LEU   A 1 171  ? 108.717 154.849 138.443 1.00 22.03  ?  171  LEU   C CA    1 
ATOM   341  C C     . LEU   A 1 171  ? 109.837 154.169 137.680 1.00 24.14  ?  171  LEU   C C     1 
ATOM   342  O O     . LEU   A 1 171  ? 109.600 153.209 136.946 1.00 26.49  ?  171  LEU   C O     1 
ATOM   343  C CB    . LEU   A 1 171  ? 108.642 154.275 139.862 1.00 21.08  ?  171  LEU   C CB    1 
ATOM   344  C CG    . LEU   A 1 171  ? 107.557 154.865 140.775 1.00 19.82  ?  171  LEU   C CG    1 
ATOM   345  C CD1   . LEU   A 1 171  ? 107.491 154.050 142.061 1.00 19.94  ?  171  LEU   C CD1   1 
ATOM   346  C CD2   . LEU   A 1 171  ? 107.886 156.326 141.083 1.00 15.39  ?  171  LEU   C CD2   1 
ATOM   347  N N     . ARG   A 1 172  ? 111.056 154.656 137.853 1.00 22.58  ?  172  ARG   C N     1 
ATOM   348  C CA    . ARG   A 1 172  ? 112.205 154.052 137.199 1.00 22.94  ?  172  ARG   C CA    1 
ATOM   349  C C     . ARG   A 1 172  ? 112.822 152.963 138.068 1.00 22.41  ?  172  ARG   C C     1 
ATOM   350  O O     . ARG   A 1 172  ? 113.207 153.210 139.208 1.00 21.26  ?  172  ARG   C O     1 
ATOM   351  C CB    . ARG   A 1 172  ? 113.238 155.116 136.869 1.00 24.36  ?  172  ARG   C CB    1 
ATOM   352  C CG    . ARG   A 1 172  ? 112.839 156.069 135.757 1.00 29.87  ?  172  ARG   C CG    1 
ATOM   353  C CD    . ARG   A 1 172  ? 113.852 157.136 135.552 1.00 27.17  ?  172  ARG   C CD    1 
ATOM   354  N NE    . ARG   A 1 172  ? 113.859 158.105 136.641 1.00 22.80  ?  172  ARG   C NE    1 
ATOM   355  C CZ    . ARG   A 1 172  ? 114.844 158.998 136.874 1.00 23.28  ?  172  ARG   C CZ    1 
ATOM   356  N NH1   . ARG   A 1 172  ? 115.906 159.034 136.098 1.00 33.25  1  172  ARG   C NH1   1 
ATOM   357  N NH2   . ARG   A 1 172  ? 114.741 159.841 137.885 1.00 18.90  ?  172  ARG   C NH2   1 
ATOM   358  N N     . LEU   A 1 173  ? 112.907 151.750 137.541 1.00 23.87  ?  173  LEU   C N     1 
ATOM   359  C CA    . LEU   A 1 173  ? 113.444 150.645 138.324 1.00 22.38  ?  173  LEU   C CA    1 
ATOM   360  C C     . LEU   A 1 173  ? 114.728 150.096 137.728 1.00 27.28  ?  173  LEU   C C     1 
ATOM   361  O O     . LEU   A 1 173  ? 114.753 149.656 136.577 1.00 34.21  ?  173  LEU   C O     1 
ATOM   362  C CB    . LEU   A 1 173  ? 112.408 149.529 138.420 1.00 24.18  ?  173  LEU   C CB    1 
ATOM   363  C CG    . LEU   A 1 173  ? 111.046 149.934 138.985 1.00 24.66  ?  173  LEU   C CG    1 
ATOM   364  C CD1   . LEU   A 1 173  ? 110.121 148.754 138.908 1.00 32.64  ?  173  LEU   C CD1   1 
ATOM   365  C CD2   . LEU   A 1 173  ? 111.195 150.405 140.419 1.00 20.77  ?  173  LEU   C CD2   1 
ATOM   366  N N     . ILE   A 1 174  ? 115.794 150.131 138.521 1.00 24.64  ?  174  ILE   C N     1 
ATOM   367  C CA    . ILE   A 1 174  ? 117.098 149.652 138.080 1.00 26.14  ?  174  ILE   C CA    1 
ATOM   368  C C     . ILE   A 1 174  ? 117.567 148.458 138.890 1.00 24.05  ?  174  ILE   C C     1 
ATOM   369  O O     . ILE   A 1 174  ? 117.671 148.526 140.113 1.00 24.86  ?  174  ILE   C O     1 
ATOM   370  C CB    . ILE   A 1 174  ? 118.160 150.765 138.170 1.00 28.18  ?  174  ILE   C CB    1 
ATOM   371  C CG1   . ILE   A 1 174  ? 117.778 151.927 137.238 1.00 32.37  ?  174  ILE   C CG1   1 
ATOM   372  C CG2   . ILE   A 1 174  ? 119.535 150.209 137.823 1.00 38.14  ?  174  ILE   C CG2   1 
ATOM   373  C CD1   . ILE   A 1 174  ? 118.683 153.141 137.359 1.00 42.35  ?  174  ILE   C CD1   1 
ATOM   374  N N     . LYS   A 1 175  ? 117.873 147.369 138.202 1.00 30.46  ?  175  LYS   C N     1 
ATOM   375  C CA    . LYS   A 1 175  ? 118.375 146.175 138.862 1.00 29.88  ?  175  LYS   C CA    1 
ATOM   376  C C     . LYS   A 1 175  ? 119.876 146.299 139.116 1.00 32.41  ?  175  LYS   C C     1 
ATOM   377  O O     . LYS   A 1 175  ? 120.628 146.700 138.222 1.00 34.41  ?  175  LYS   C O     1 
ATOM   378  C CB    . LYS   A 1 175  ? 118.074 144.939 138.018 1.00 35.13  ?  175  LYS   C CB    1 
ATOM   379  C CG    . LYS   A 1 175  ? 118.483 143.607 138.644 1.00 38.54  ?  175  LYS   C CG    1 
ATOM   380  C CD    . LYS   A 1 175  ? 117.945 142.417 137.837 1.00 38.97  ?  175  LYS   C CD    1 
ATOM   381  C CE    . LYS   A 1 175  ? 118.689 142.255 136.507 1.00 45.74  ?  175  LYS   C CE    1 
ATOM   382  N NZ    . LYS   A 1 175  ? 118.324 140.990 135.812 1.00 47.10  1  175  LYS   C NZ    1 
ATOM   383  N N     . GLU   A 1 176  ? 120.302 145.937 140.334 1.00 32.93  ?  176  GLU   C N     1 
ATOM   384  C CA    . GLU   A 1 176  ? 121.702 145.988 140.767 1.00 34.83  ?  176  GLU   C CA    1 
ATOM   385  C C     . GLU   A 1 176  ? 122.142 144.621 141.292 1.00 35.47  ?  176  GLU   C C     1 
ATOM   386  O O     . GLU   A 1 176  ? 122.089 144.339 142.492 1.00 34.67  ?  176  GLU   C O     1 
ATOM   387  C CB    . GLU   A 1 176  ? 121.906 147.077 141.850 1.00 31.26  ?  176  GLU   C CB    1 
ATOM   388  C CG    . GLU   A 1 176  ? 121.747 148.560 141.369 1.00 38.58  ?  176  GLU   C CG    1 
ATOM   389  C CD    . GLU   A 1 176  ? 122.925 149.089 140.525 1.00 49.46  ?  176  GLU   C CD    1 
ATOM   390  O OE1   . GLU   A 1 176  ? 123.907 148.395 140.386 1.00 43.24  ?  176  GLU   C OE1   1 
ATOM   391  O OE2   . GLU   A 1 176  ? 122.833 150.197 140.048 1.00 45.32  -1 176  GLU   C OE2   1 
ATOM   392  N N     . SER   A 1 201  ? 120.647 148.001 135.359 1.00 39.04  ?  201  SER   C N     1 
ATOM   393  C CA    . SER   A 1 201  ? 119.920 147.612 134.158 1.00 49.42  ?  201  SER   C CA    1 
ATOM   394  C C     . SER   A 1 201  ? 118.394 147.775 134.381 1.00 45.06  ?  201  SER   C C     1 
ATOM   395  O O     . SER   A 1 201  ? 117.888 147.287 135.396 1.00 42.18  ?  201  SER   C O     1 
ATOM   396  C CB    . SER   A 1 201  ? 120.262 146.171 133.788 1.00 52.31  ?  201  SER   C CB    1 
ATOM   397  O OG    . SER   A 1 201  ? 119.566 145.756 132.644 1.00 52.92  ?  201  SER   C OG    1 
ATOM   398  N N     . PRO   A 1 202  ? 117.635 148.454 133.471 1.00 48.65  ?  202  PRO   C N     1 
ATOM   399  C CA    . PRO   A 1 202  ? 116.202 148.721 133.582 1.00 50.58  ?  202  PRO   C CA    1 
ATOM   400  C C     . PRO   A 1 202  ? 115.378 147.439 133.515 1.00 50.69  ?  202  PRO   C C     1 
ATOM   401  O O     . PRO   A 1 202  ? 115.662 146.555 132.707 1.00 48.64  ?  202  PRO   C O     1 
ATOM   402  C CB    . PRO   A 1 202  ? 115.928 149.621 132.366 1.00 56.78  ?  202  PRO   C CB    1 
ATOM   403  C CG    . PRO   A 1 202  ? 117.018 149.290 131.372 1.00 61.79  ?  202  PRO   C CG    1 
ATOM   404  C CD    . PRO   A 1 202  ? 118.235 148.964 132.204 1.00 57.01  ?  202  PRO   C CD    1 
ATOM   405  N N     . ILE   A 1 203  ? 114.349 147.358 134.353 1.00 48.16  ?  203  ILE   C N     1 
ATOM   406  C CA    . ILE   A 1 203  ? 113.506 146.167 134.399 1.00 45.67  ?  203  ILE   C CA    1 
ATOM   407  C C     . ILE   A 1 203  ? 112.016 146.460 134.321 1.00 45.80  ?  203  ILE   C C     1 
ATOM   408  O O     . ILE   A 1 203  ? 111.574 147.592 134.504 1.00 43.74  ?  203  ILE   C O     1 
ATOM   409  C CB    . ILE   A 1 203  ? 113.778 145.351 135.670 1.00 40.85  ?  203  ILE   C CB    1 
ATOM   410  C CG1   . ILE   A 1 203  ? 113.425 146.197 136.913 1.00 36.50  ?  203  ILE   C CG1   1 
ATOM   411  C CG2   . ILE   A 1 203  ? 115.222 144.889 135.689 1.00 45.55  ?  203  ILE   C CG2   1 
ATOM   412  C CD1   . ILE   A 1 203  ? 113.466 145.445 138.214 1.00 42.59  ?  203  ILE   C CD1   1 
ATOM   413  N N     . LYS   A 1 204  ? 111.251 145.402 134.070 1.00 47.02  ?  204  LYS   C N     1 
ATOM   414  C CA    . LYS   A 1 204  ? 109.793 145.440 134.078 1.00 46.37  ?  204  LYS   C CA    1 
ATOM   415  C C     . LYS   A 1 204  ? 109.272 144.820 135.364 1.00 47.86  ?  204  LYS   C C     1 
ATOM   416  O O     . LYS   A 1 204  ? 110.001 144.082 136.035 1.00 46.56  ?  204  LYS   C O     1 
ATOM   417  C CB    . LYS   A 1 204  ? 109.230 144.691 132.867 1.00 52.08  ?  204  LYS   C CB    1 
ATOM   418  C CG    . LYS   A 1 204  ? 109.735 145.188 131.506 1.00 55.80  ?  204  LYS   C CG    1 
ATOM   419  C CD    . LYS   A 1 204  ? 109.297 146.618 131.231 1.00 57.81  ?  204  LYS   C CD    1 
ATOM   420  C CE    . LYS   A 1 204  ? 109.675 147.046 129.829 1.00 62.79  ?  204  LYS   C CE    1 
ATOM   421  N NZ    . LYS   A 1 204  ? 109.310 148.456 129.574 1.00 69.62  1  204  LYS   C NZ    1 
ATOM   422  N N     . MET   A 1 205  ? 108.022 145.096 135.714 1.00 46.61  ?  205  MET   C N     1 
ATOM   423  C CA    . MET   A 1 205  ? 107.421 144.518 136.911 1.00 46.22  ?  205  MET   C CA    1 
ATOM   424  C C     . MET   A 1 205  ? 107.203 143.021 136.779 1.00 47.04  ?  205  MET   C C     1 
ATOM   425  O O     . MET   A 1 205  ? 107.226 142.296 137.767 1.00 46.34  ?  205  MET   C O     1 
ATOM   426  C CB    . MET   A 1 205  ? 106.118 145.216 137.263 1.00 49.10  ?  205  MET   C CB    1 
ATOM   427  C CG    . MET   A 1 205  ? 106.301 146.632 137.732 1.00 50.29  ?  205  MET   C CG    1 
ATOM   428  S SD    . MET   A 1 205  ? 107.518 146.758 139.054 1.00 54.47  ?  205  MET   C SD    1 
ATOM   429  C CE    . MET   A 1 205  ? 106.768 145.863 140.392 1.00 44.16  ?  205  MET   C CE    1 
ATOM   430  N N     . GLU   A 1 206  ? 106.966 142.567 135.555 1.00 47.58  ?  206  GLU   C N     1 
ATOM   431  C CA    . GLU   A 1 206  ? 106.789 141.144 135.313 1.00 49.12  ?  206  GLU   C CA    1 
ATOM   432  C C     . GLU   A 1 206  ? 108.158 140.514 135.117 1.00 50.60  ?  206  GLU   C C     1 
ATOM   433  O O     . GLU   A 1 206  ? 109.111 141.203 134.761 1.00 51.51  ?  206  GLU   C O     1 
ATOM   434  C CB    . GLU   A 1 206  ? 105.869 140.919 134.106 1.00 50.86  ?  206  GLU   C CB    1 
ATOM   435  C CG    . GLU   A 1 206  ? 105.493 139.463 133.843 1.00 54.67  ?  206  GLU   C CG    1 
ATOM   436  C CD    . GLU   A 1 206  ? 104.886 138.784 135.041 1.00 55.09  ?  206  GLU   C CD    1 
ATOM   437  O OE1   . GLU   A 1 206  ? 103.682 138.804 135.184 1.00 49.86  ?  206  GLU   C OE1   1 
ATOM   438  O OE2   . GLU   A 1 206  ? 105.643 138.251 135.823 1.00 53.16  -1 206  GLU   C OE2   1 
ATOM   439  N N     . LEU   A 1 207  ? 108.266 139.212 135.370 1.00 51.44  ?  207  LEU   C N     1 
ATOM   440  C CA    . LEU   A 1 207  ? 109.530 138.479 135.249 1.00 54.14  ?  207  LEU   C CA    1 
ATOM   441  C C     . LEU   A 1 207  ? 110.507 138.870 136.359 1.00 51.79  ?  207  LEU   C C     1 
ATOM   442  O O     . LEU   A 1 207  ? 111.674 138.485 136.341 1.00 52.44  ?  207  LEU   C O     1 
ATOM   443  C CB    . LEU   A 1 207  ? 110.194 138.769 133.886 1.00 57.32  ?  207  LEU   C CB    1 
ATOM   444  C CG    . LEU   A 1 207  ? 109.273 138.704 132.631 1.00 60.99  ?  207  LEU   C CG    1 
ATOM   445  C CD1   . LEU   A 1 207  ? 110.080 139.075 131.394 1.00 54.78  ?  207  LEU   C CD1   1 
ATOM   446  C CD2   . LEU   A 1 207  ? 108.687 137.310 132.497 1.00 59.81  ?  207  LEU   C CD2   1 
ATOM   447  N N     . LEU   A 1 208  ? 110.012 139.596 137.353 1.00 46.81  ?  208  LEU   C N     1 
ATOM   448  C CA    . LEU   A 1 208  ? 110.820 140.068 138.473 1.00 43.75  ?  208  LEU   C CA    1 
ATOM   449  C C     . LEU   A 1 208  ? 111.440 138.926 139.260 1.00 42.78  ?  208  LEU   C C     1 
ATOM   450  O O     . LEU   A 1 208  ? 112.569 139.031 139.741 1.00 43.41  ?  208  LEU   C O     1 
ATOM   451  C CB    . LEU   A 1 208  ? 109.952 140.907 139.411 1.00 42.92  ?  208  LEU   C CB    1 
ATOM   452  C CG    . LEU   A 1 208  ? 110.634 141.497 140.652 1.00 34.69  ?  208  LEU   C CG    1 
ATOM   453  C CD1   . LEU   A 1 208  ? 111.748 142.464 140.239 1.00 35.66  ?  208  LEU   C CD1   1 
ATOM   454  C CD2   . LEU   A 1 208  ? 109.581 142.199 141.477 1.00 36.10  ?  208  LEU   C CD2   1 
ATOM   455  N N     . PHE   A 1 209  ? 110.693 137.843 139.405 1.00 45.57  ?  209  PHE   C N     1 
ATOM   456  C CA    . PHE   A 1 209  ? 111.138 136.705 140.188 1.00 47.28  ?  209  PHE   C CA    1 
ATOM   457  C C     . PHE   A 1 209  ? 111.672 135.569 139.329 1.00 52.27  ?  209  PHE   C C     1 
ATOM   458  O O     . PHE   A 1 209  ? 111.860 134.455 139.816 1.00 51.93  ?  209  PHE   C O     1 
ATOM   459  C CB    . PHE   A 1 209  ? 110.002 136.188 141.063 1.00 45.28  ?  209  PHE   C CB    1 
ATOM   460  C CG    . PHE   A 1 209  ? 109.646 137.100 142.175 1.00 39.69  ?  209  PHE   C CG    1 
ATOM   461  C CD1   . PHE   A 1 209  ? 108.662 138.056 142.025 1.00 33.86  ?  209  PHE   C CD1   1 
ATOM   462  C CD2   . PHE   A 1 209  ? 110.297 136.995 143.388 1.00 39.23  ?  209  PHE   C CD2   1 
ATOM   463  C CE1   . PHE   A 1 209  ? 108.341 138.888 143.063 1.00 31.63  ?  209  PHE   C CE1   1 
ATOM   464  C CE2   . PHE   A 1 209  ? 109.975 137.824 144.428 1.00 33.27  ?  209  PHE   C CE2   1 
ATOM   465  C CZ    . PHE   A 1 209  ? 108.999 138.773 144.264 1.00 28.40  ?  209  PHE   C CZ    1 
ATOM   466  N N     . ASP   A 1 210  ? 111.907 135.832 138.048 1.00 55.16  ?  210  ASP   C N     1 
ATOM   467  C CA    . ASP   A 1 210  ? 112.459 134.796 137.193 1.00 57.52  ?  210  ASP   C CA    1 
ATOM   468  C C     . ASP   A 1 210  ? 113.904 134.496 137.581 1.00 61.01  ?  210  ASP   C C     1 
ATOM   469  O O     . ASP   A 1 210  ? 114.604 135.384 138.076 1.00 61.61  ?  210  ASP   C O     1 
ATOM   470  C CB    . ASP   A 1 210  ? 112.392 135.187 135.717 1.00 62.37  ?  210  ASP   C CB    1 
ATOM   471  C CG    . ASP   A 1 210  ? 111.022 134.979 135.112 1.00 59.96  ?  210  ASP   C CG    1 
ATOM   472  O OD1   . ASP   A 1 210  ? 110.193 134.350 135.733 1.00 59.27  ?  210  ASP   C OD1   1 
ATOM   473  O OD2   . ASP   A 1 210  ? 110.820 135.420 134.014 1.00 59.30  -1 210  ASP   C OD2   1 
ATOM   474  N N     . PRO   A 1 211  ? 114.369 133.261 137.346 1.00 69.17  ?  211  PRO   C N     1 
ATOM   475  C CA    . PRO   A 1 211  ? 115.737 132.813 137.479 1.00 87.59  ?  211  PRO   C CA    1 
ATOM   476  C C     . PRO   A 1 211  ? 116.656 133.673 136.637 1.00 86.99  ?  211  PRO   C C     1 
ATOM   477  O O     . PRO   A 1 211  ? 116.229 134.259 135.642 1.00 77.73  ?  211  PRO   C O     1 
ATOM   478  C CB    . PRO   A 1 211  ? 115.678 131.376 136.955 1.00 91.74  ?  211  PRO   C CB    1 
ATOM   479  C CG    . PRO   A 1 211  ? 114.258 130.945 137.169 1.00 76.60  ?  211  PRO   C CG    1 
ATOM   480  C CD    . PRO   A 1 211  ? 113.429 132.193 136.968 1.00 71.98  ?  211  PRO   C CD    1 
ATOM   481  N N     . ASP   A 1 212  ? 117.909 133.771 137.052 1.00 87.54  ?  212  ASP   C N     1 
ATOM   482  C CA    . ASP   A 1 212  ? 118.858 134.633 136.361 1.00 90.16  ?  212  ASP   C CA    1 
ATOM   483  C C     . ASP   A 1 212  ? 119.413 133.978 135.100 1.00 71.72  ?  212  ASP   C C     1 
ATOM   484  O O     . ASP   A 1 212  ? 118.868 132.994 134.594 1.00 93.57  ?  212  ASP   C O     1 
ATOM   485  C CB    . ASP   A 1 212  ? 120.004 135.060 137.283 1.00 91.48  ?  212  ASP   C CB    1 
ATOM   486  C CG    . ASP   A 1 212  ? 120.962 133.956 137.612 1.00 109.74 ?  212  ASP   C CG    1 
ATOM   487  O OD1   . ASP   A 1 212  ? 120.841 132.902 137.040 1.00 110.01 ?  212  ASP   C OD1   1 
ATOM   488  O OD2   . ASP   A 1 212  ? 121.827 134.176 138.426 1.00 113.48 -1 212  ASP   C OD2   1 
ATOM   489  N N     . ASP   A 1 213  ? 120.470 134.573 134.562 1.00 106.25 ?  213  ASP   C N     1 
ATOM   490  C CA    . ASP   A 1 213  ? 120.989 134.211 133.253 1.00 97.89  ?  213  ASP   C CA    1 
ATOM   491  C C     . ASP   A 1 213  ? 121.864 132.961 133.223 1.00 148.78 ?  213  ASP   C C     1 
ATOM   492  O O     . ASP   A 1 213  ? 122.321 132.565 132.151 1.00 136.27 ?  213  ASP   C O     1 
ATOM   493  C CB    . ASP   A 1 213  ? 121.789 135.384 132.689 1.00 89.19  ?  213  ASP   C CB    1 
ATOM   494  C CG    . ASP   A 1 213  ? 120.917 136.591 132.378 1.00 111.83 ?  213  ASP   C CG    1 
ATOM   495  O OD1   . ASP   A 1 213  ? 119.741 136.416 132.162 1.00 108.59 ?  213  ASP   C OD1   1 
ATOM   496  O OD2   . ASP   A 1 213  ? 121.435 137.681 132.370 1.00 127.27 -1 213  ASP   C OD2   1 
ATOM   497  N N     . GLU   A 1 214  ? 122.125 132.346 134.375 1.00 141.46 ?  214  GLU   C N     1 
ATOM   498  C CA    . GLU   A 1 214  ? 122.980 131.162 134.377 1.00 125.68 ?  214  GLU   C CA    1 
ATOM   499  C C     . GLU   A 1 214  ? 122.567 130.160 135.453 1.00 106.87 ?  214  GLU   C C     1 
ATOM   500  O O     . GLU   A 1 214  ? 122.108 130.534 136.529 1.00 88.66  ?  214  GLU   C O     1 
ATOM   501  C CB    . GLU   A 1 214  ? 124.448 131.565 134.538 1.00 101.36 ?  214  GLU   C CB    1 
ATOM   502  C CG    . GLU   A 1 214  ? 125.443 130.416 134.386 1.00 89.61  ?  214  GLU   C CG    1 
ATOM   503  C CD    . GLU   A 1 214  ? 125.367 129.730 133.046 1.00 96.54  ?  214  GLU   C CD    1 
ATOM   504  O OE1   . GLU   A 1 214  ? 126.226 129.961 132.230 1.00 122.88 ?  214  GLU   C OE1   1 
ATOM   505  O OE2   . GLU   A 1 214  ? 124.439 128.971 132.842 1.00 101.68 -1 214  GLU   C OE2   1 
ATOM   506  N N     . HIS   A 1 215  ? 122.685 128.874 135.124 1.00 125.97 ?  215  HIS   C N     1 
ATOM   507  C CA    . HIS   A 1 215  ? 122.300 127.769 136.011 1.00 125.67 ?  215  HIS   C CA    1 
ATOM   508  C C     . HIS   A 1 215  ? 120.804 127.786 136.316 1.00 93.28  ?  215  HIS   C C     1 
ATOM   509  O O     . HIS   A 1 215  ? 120.326 127.025 137.157 1.00 142.94 ?  215  HIS   C O     1 
ATOM   510  C CB    . HIS   A 1 215  ? 123.065 127.824 137.347 1.00 134.62 ?  215  HIS   C CB    1 
ATOM   511  C CG    . HIS   A 1 215  ? 124.556 127.879 137.213 1.00 110.90 ?  215  HIS   C CG    1 
ATOM   512  N ND1   . HIS   A 1 215  ? 125.287 126.891 136.586 1.00 138.95 ?  215  HIS   C ND1   1 
ATOM   513  C CD2   . HIS   A 1 215  ? 125.453 128.799 137.640 1.00 124.40 ?  215  HIS   C CD2   1 
ATOM   514  C CE1   . HIS   A 1 215  ? 126.570 127.206 136.626 1.00 121.44 ?  215  HIS   C CE1   1 
ATOM   515  N NE2   . HIS   A 1 215  ? 126.697 128.358 137.260 1.00 134.20 ?  215  HIS   C NE2   1 
ATOM   516  N N     . SER   A 1 216  ? 120.075 128.680 135.653 1.00 92.25  ?  216  SER   C N     1 
ATOM   517  C CA    . SER   A 1 216  ? 118.657 128.878 135.904 1.00 102.86 ?  216  SER   C CA    1 
ATOM   518  C C     . SER   A 1 216  ? 118.396 129.025 137.396 1.00 103.34 ?  216  SER   C C     1 
ATOM   519  O O     . SER   A 1 216  ? 117.418 128.484 137.915 1.00 112.65 ?  216  SER   C O     1 
ATOM   520  C CB    . SER   A 1 216  ? 117.847 127.722 135.354 1.00 100.40 ?  216  SER   C CB    1 
ATOM   521  O OG    . SER   A 1 216  ? 117.998 127.607 133.965 1.00 106.89 ?  216  SER   C OG    1 
ATOM   522  N N     . GLU   A 1 217  ? 119.266 129.756 138.091 1.00 84.74  ?  217  GLU   C N     1 
ATOM   523  C CA    . GLU   A 1 217  ? 119.126 129.894 139.535 1.00 66.68  ?  217  GLU   C CA    1 
ATOM   524  C C     . GLU   A 1 217  ? 117.932 130.781 139.897 1.00 76.91  ?  217  GLU   C C     1 
ATOM   525  O O     . GLU   A 1 217  ? 117.897 131.946 139.501 1.00 76.69  ?  217  GLU   C O     1 
ATOM   526  C CB    . GLU   A 1 217  ? 120.410 130.465 140.139 1.00 143.80 ?  217  GLU   C CB    1 
ATOM   527  C CG    . GLU   A 1 217  ? 120.399 130.557 141.660 1.00 85.76  ?  217  GLU   C CG    1 
ATOM   528  C CD    . GLU   A 1 217  ? 121.722 130.980 142.253 1.00 92.85  ?  217  GLU   C CD    1 
ATOM   529  O OE1   . GLU   A 1 217  ? 122.664 131.146 141.520 1.00 84.48  ?  217  GLU   C OE1   1 
ATOM   530  O OE2   . GLU   A 1 217  ? 121.784 131.128 143.450 1.00 84.15  -1 217  GLU   C OE2   1 
ATOM   531  N N     . PRO   A 1 218  ? 116.946 130.254 140.645 1.00 118.59 ?  218  PRO   C N     1 
ATOM   532  C CA    . PRO   A 1 218  ? 115.705 130.905 141.026 1.00 82.37  ?  218  PRO   C CA    1 
ATOM   533  C C     . PRO   A 1 218  ? 115.951 131.962 142.085 1.00 77.21  ?  218  PRO   C C     1 
ATOM   534  O O     . PRO   A 1 218  ? 116.924 131.879 142.834 1.00 72.65  ?  218  PRO   C O     1 
ATOM   535  C CB    . PRO   A 1 218  ? 114.873 129.743 141.580 1.00 83.74  ?  218  PRO   C CB    1 
ATOM   536  C CG    . PRO   A 1 218  ? 115.897 128.767 142.122 1.00 80.87  ?  218  PRO   C CG    1 
ATOM   537  C CD    . PRO   A 1 218  ? 117.087 128.884 141.184 1.00 83.05  ?  218  PRO   C CD    1 
ATOM   538  N N     . VAL   A 1 219  ? 115.045 132.924 142.175 1.00 68.81  ?  219  VAL   C N     1 
ATOM   539  C CA    . VAL   A 1 219  ? 115.123 133.952 143.203 1.00 59.83  ?  219  VAL   C CA    1 
ATOM   540  C C     . VAL   A 1 219  ? 113.885 133.935 144.084 1.00 55.28  ?  219  VAL   C C     1 
ATOM   541  O O     . VAL   A 1 219  ? 112.761 133.877 143.592 1.00 52.96  ?  219  VAL   C O     1 
ATOM   542  C CB    . VAL   A 1 219  ? 115.282 135.342 142.556 1.00 54.65  ?  219  VAL   C CB    1 
ATOM   543  C CG1   . VAL   A 1 219  ? 114.143 135.604 141.616 1.00 54.14  ?  219  VAL   C CG1   1 
ATOM   544  C CG2   . VAL   A 1 219  ? 115.318 136.422 143.632 1.00 47.75  ?  219  VAL   C CG2   1 
ATOM   545  N N     . HIS   A 1 220  ? 114.085 133.996 145.390 1.00 51.10  ?  220  HIS   C N     1 
ATOM   546  C CA    . HIS   A 1 220  ? 112.952 134.043 146.299 1.00 46.14  ?  220  HIS   C CA    1 
ATOM   547  C C     . HIS   A 1 220  ? 112.812 135.413 146.931 1.00 40.04  ?  220  HIS   C C     1 
ATOM   548  O O     . HIS   A 1 220  ? 111.702 135.855 147.223 1.00 39.77  ?  220  HIS   C O     1 
ATOM   549  C CB    . HIS   A 1 220  ? 113.088 132.989 147.396 1.00 49.23  ?  220  HIS   C CB    1 
ATOM   550  C CG    . HIS   A 1 220  ? 113.050 131.588 146.884 1.00 57.11  ?  220  HIS   C CG    1 
ATOM   551  N ND1   . HIS   A 1 220  ? 114.185 130.907 146.490 1.00 63.21  ?  220  HIS   C ND1   1 
ATOM   552  C CD2   . HIS   A 1 220  ? 112.015 130.738 146.695 1.00 56.68  ?  220  HIS   C CD2   1 
ATOM   553  C CE1   . HIS   A 1 220  ? 113.844 129.695 146.079 1.00 63.53  ?  220  HIS   C CE1   1 
ATOM   554  N NE2   . HIS   A 1 220  ? 112.536 129.570 146.192 1.00 59.68  ?  220  HIS   C NE2   1 
ATOM   555  N N     . THR   A 1 221  ? 113.936 136.087 147.149 1.00 38.22  ?  221  THR   C N     1 
ATOM   556  C CA    . THR   A 1 221  ? 113.905 137.365 147.839 1.00 31.24  ?  221  THR   C CA    1 
ATOM   557  C C     . THR   A 1 221  ? 114.315 138.516 146.941 1.00 28.01  ?  221  THR   C C     1 
ATOM   558  O O     . THR   A 1 221  ? 115.395 138.504 146.347 1.00 31.98  ?  221  THR   C O     1 
ATOM   559  C CB    . THR   A 1 221  ? 114.816 137.336 149.077 1.00 32.61  ?  221  THR   C CB    1 
ATOM   560  O OG1   . THR   A 1 221  ? 114.371 136.310 149.969 1.00 40.28  ?  221  THR   C OG1   1 
ATOM   561  C CG2   . THR   A 1 221  ? 114.765 138.664 149.794 1.00 30.70  ?  221  THR   C CG2   1 
ATOM   562  N N     . VAL   A 1 222  ? 113.449 139.514 146.867 1.00 27.60  ?  222  VAL   C N     1 
ATOM   563  C CA    . VAL   A 1 222  ? 113.708 140.718 146.093 1.00 23.60  ?  222  VAL   C CA    1 
ATOM   564  C C     . VAL   A 1 222  ? 113.583 141.936 146.990 1.00 20.78  ?  222  VAL   C C     1 
ATOM   565  O O     . VAL   A 1 222  ? 112.595 142.087 147.705 1.00 21.95  ?  222  VAL   C O     1 
ATOM   566  C CB    . VAL   A 1 222  ? 112.735 140.832 144.908 1.00 22.89  ?  222  VAL   C CB    1 
ATOM   567  C CG1   . VAL   A 1 222  ? 112.998 142.113 144.145 1.00 23.45  ?  222  VAL   C CG1   1 
ATOM   568  C CG2   . VAL   A 1 222  ? 112.905 139.627 143.993 1.00 30.07  ?  222  VAL   C CG2   1 
ATOM   569  N N     . VAL   A 1 223  ? 114.587 142.794 146.970 1.00 20.62  ?  223  VAL   C N     1 
ATOM   570  C CA    . VAL   A 1 223  ? 114.574 143.970 147.817 1.00 17.65  ?  223  VAL   C CA    1 
ATOM   571  C C     . VAL   A 1 223  ? 114.539 145.246 147.001 1.00 17.15  ?  223  VAL   C C     1 
ATOM   572  O O     . VAL   A 1 223  ? 115.397 145.476 146.150 1.00 19.99  ?  223  VAL   C O     1 
ATOM   573  C CB    . VAL   A 1 223  ? 115.807 143.985 148.732 1.00 17.67  ?  223  VAL   C CB    1 
ATOM   574  C CG1   . VAL   A 1 223  ? 115.783 145.222 149.628 1.00 16.44  ?  223  VAL   C CG1   1 
ATOM   575  C CG2   . VAL   A 1 223  ? 115.831 142.726 149.556 1.00 19.35  ?  223  VAL   C CG2   1 
ATOM   576  N N     . PHE   A 1 224  ? 113.547 146.075 147.281 1.00 15.84  ?  224  PHE   C N     1 
ATOM   577  C CA    . PHE   A 1 224  ? 113.383 147.360 146.629 1.00 14.60  ?  224  PHE   C CA    1 
ATOM   578  C C     . PHE   A 1 224  ? 113.820 148.478 147.539 1.00 13.28  ?  224  PHE   C C     1 
ATOM   579  O O     . PHE   A 1 224  ? 113.234 148.690 148.599 1.00 15.85  ?  224  PHE   C O     1 
ATOM   580  C CB    . PHE   A 1 224  ? 111.935 147.586 146.229 1.00 18.00  ?  224  PHE   C CB    1 
ATOM   581  C CG    . PHE   A 1 224  ? 111.521 146.841 145.025 1.00 19.21  ?  224  PHE   C CG    1 
ATOM   582  C CD1   . PHE   A 1 224  ? 111.243 145.506 145.087 1.00 20.45  ?  224  PHE   C CD1   1 
ATOM   583  C CD2   . PHE   A 1 224  ? 111.404 147.486 143.812 1.00 20.46  ?  224  PHE   C CD2   1 
ATOM   584  C CE1   . PHE   A 1 224  ? 110.865 144.828 143.970 1.00 23.60  ?  224  PHE   C CE1   1 
ATOM   585  C CE2   . PHE   A 1 224  ? 111.019 146.807 142.690 1.00 23.97  ?  224  PHE   C CE2   1 
ATOM   586  C CZ    . PHE   A 1 224  ? 110.749 145.475 142.767 1.00 25.07  ?  224  PHE   C CZ    1 
ATOM   587  N N     . GLN   A 1 225  ? 114.844 149.200 147.138 1.00 14.97  ?  225  GLN   C N     1 
ATOM   588  C CA    . GLN   A 1 225  ? 115.336 150.257 147.992 1.00 11.59  ?  225  GLN   C CA    1 
ATOM   589  C C     . GLN   A 1 225  ? 115.084 151.609 147.368 1.00 9.69   ?  225  GLN   C C     1 
ATOM   590  O O     . GLN   A 1 225  ? 115.149 151.761 146.150 1.00 12.96  ?  225  GLN   C O     1 
ATOM   591  C CB    . GLN   A 1 225  ? 116.822 150.070 148.281 1.00 12.40  ?  225  GLN   C CB    1 
ATOM   592  C CG    . GLN   A 1 225  ? 117.708 150.214 147.071 1.00 15.86  ?  225  GLN   C CG    1 
ATOM   593  C CD    . GLN   A 1 225  ? 119.143 149.895 147.372 1.00 20.99  ?  225  GLN   C CD    1 
ATOM   594  O OE1   . GLN   A 1 225  ? 119.487 148.742 147.644 1.00 22.03  ?  225  GLN   C OE1   1 
ATOM   595  N NE2   . GLN   A 1 225  ? 119.999 150.907 147.335 1.00 22.73  ?  225  GLN   C NE2   1 
ATOM   596  N N     . GLY   A 1 226  ? 114.834 152.601 148.204 1.00 9.79   ?  226  GLY   C N     1 
ATOM   597  C CA    . GLY   A 1 226  ? 114.642 153.948 147.691 1.00 9.02   ?  226  GLY   C CA    1 
ATOM   598  C C     . GLY   A 1 226  ? 114.412 154.992 148.776 1.00 8.88   ?  226  GLY   C C     1 
ATOM   599  O O     . GLY   A 1 226  ? 114.172 154.671 149.941 1.00 12.14  ?  226  GLY   C O     1 
ATOM   600  N N     . ALA   A 1 227  ? 114.460 156.203 148.339 1.00 8.32   ?  227  ALA   C N     1 
ATOM   601  C CA    . ALA   A 1 227  ? 114.361 157.303 149.260 1.00 6.71   ?  227  ALA   C CA    1 
ATOM   602  C C     . ALA   A 1 227  ? 112.988 157.434 149.822 1.00 7.98   ?  227  ALA   C C     1 
ATOM   603  O O     . ALA   A 1 227  ? 112.079 156.891 149.280 1.00 11.19  ?  227  ALA   C O     1 
ATOM   604  C CB    . ALA   A 1 227  ? 114.657 158.462 148.402 1.00 10.65  ?  227  ALA   C CB    1 
ATOM   605  N N     . ALA   A 1 228  ? 112.875 158.221 150.862 1.00 9.66   ?  228  ALA   C N     1 
ATOM   606  C CA    . ALA   A 1 228  ? 111.589 158.525 151.468 1.00 6.99   ?  228  ALA   C CA    1 
ATOM   607  C C     . ALA   A 1 228  ? 110.775 159.343 150.507 1.00 7.58   ?  228  ALA   C C     1 
ATOM   608  O O     . ALA   A 1 228  ? 111.148 160.455 150.276 1.00 12.89  ?  228  ALA   C O     1 
ATOM   609  C CB    . ALA   A 1 228  ? 111.946 159.343 152.626 1.00 10.48  ?  228  ALA   C CB    1 
ATOM   610  N N     . GLY   A 1 229  ? 109.707 158.804 149.969 1.00 9.94   ?  229  GLY   C N     1 
ATOM   611  C CA    . GLY   A 1 229  ? 108.820 159.530 149.058 1.00 9.58   ?  229  GLY   C CA    1 
ATOM   612  C C     . GLY   A 1 229  ? 108.915 159.035 147.657 1.00 7.48   ?  229  GLY   C C     1 
ATOM   613  O O     . GLY   A 1 229  ? 108.088 159.382 146.914 1.00 10.37  ?  229  GLY   C O     1 
ATOM   614  N N     . ILE   A 1 230  ? 109.836 158.164 147.373 1.00 8.25   ?  230  ILE   C N     1 
ATOM   615  C CA    . ILE   A 1 230  ? 110.101 157.765 145.977 1.00 9.35   ?  230  ILE   C CA    1 
ATOM   616  C C     . ILE   A 1 230  ? 108.947 156.935 145.438 1.00 10.97  ?  230  ILE   C C     1 
ATOM   617  O O     . ILE   A 1 230  ? 108.823 156.853 144.241 1.00 12.43  ?  230  ILE   C O     1 
ATOM   618  C CB    . ILE   A 1 230  ? 111.456 157.049 145.900 1.00 8.94   ?  230  ILE   C CB    1 
ATOM   619  C CG1   . ILE   A 1 230  ? 112.190 157.389 144.607 1.00 9.59   ?  230  ILE   C CG1   1 
ATOM   620  C CG2   . ILE   A 1 230  ? 111.336 155.558 146.167 1.00 9.48   ?  230  ILE   C CG2   1 
ATOM   621  C CD1   . ILE   A 1 230  ? 112.425 158.858 144.472 1.00 10.99  ?  230  ILE   C CD1   1 
ATOM   622  N N     . GLY   A 1 231  ? 108.148 156.351 146.300 1.00 12.62  ?  231  GLY   C N     1 
ATOM   623  C CA    . GLY   A 1 231  ? 107.038 155.509 145.881 1.00 10.49  ?  231  GLY   C CA    1 
ATOM   624  C C     . GLY   A 1 231  ? 107.331 154.075 146.145 1.00 11.27  ?  231  GLY   C C     1 
ATOM   625  O O     . GLY   A 1 231  ? 107.239 153.341 145.231 1.00 16.78  ?  231  GLY   C O     1 
ATOM   626  N N     . LYS   A 1 232  ? 107.698 153.693 147.337 1.00 11.62  ?  232  LYS   C N     1 
ATOM   627  C CA    . LYS   A 1 232  ? 107.873 152.261 147.605 1.00 11.59  ?  232  LYS   C CA    1 
ATOM   628  C C     . LYS   A 1 232  ? 106.522 151.680 147.975 1.00 15.62  ?  232  LYS   C C     1 
ATOM   629  O O     . LYS   A 1 232  ? 106.316 150.532 147.648 1.00 17.39  ?  232  LYS   C O     1 
ATOM   630  C CB    . LYS   A 1 232  ? 108.844 152.012 148.750 1.00 15.46  ?  232  LYS   C CB    1 
ATOM   631  C CG    . LYS   A 1 232  ? 110.312 152.300 148.496 1.00 13.11  ?  232  LYS   C CG    1 
ATOM   632  C CD    . LYS   A 1 232  ? 111.150 152.119 149.724 1.00 11.35  ?  232  LYS   C CD    1 
ATOM   633  C CE    . LYS   A 1 232  ? 110.709 152.973 150.889 1.00 11.40  ?  232  LYS   C CE    1 
ATOM   634  N NZ    . LYS   A 1 232  ? 110.824 154.417 150.594 1.00 11.29  1  232  LYS   C NZ    1 
ATOM   635  N N     . THR   A 1 233  ? 105.642 152.459 148.591 1.00 17.49  ?  233  THR   C N     1 
ATOM   636  C CA    . THR   A 1 233  ? 104.311 152.009 149.034 1.00 14.92  ?  233  THR   C CA    1 
ATOM   637  C C     . THR   A 1 233  ? 103.345 152.099 147.870 1.00 17.69  ?  233  THR   C C     1 
ATOM   638  O O     . THR   A 1 233  ? 102.696 151.122 147.599 1.00 19.95  ?  233  THR   C O     1 
ATOM   639  C CB    . THR   A 1 233  ? 103.856 152.830 150.227 1.00 18.56  ?  233  THR   C CB    1 
ATOM   640  O OG1   . THR   A 1 233  ? 104.445 152.175 151.341 1.00 25.20  ?  233  THR   C OG1   1 
ATOM   641  C CG2   . THR   A 1 233  ? 102.361 152.901 150.422 1.00 22.06  ?  233  THR   C CG2   1 
ATOM   642  N N     . ILE   A 1 234  ? 103.347 153.198 147.144 1.00 17.81  ?  234  ILE   C N     1 
ATOM   643  C CA    . ILE   A 1 234  ? 102.491 153.286 145.942 1.00 15.59  ?  234  ILE   C CA    1 
ATOM   644  C C     . ILE   A 1 234  ? 102.903 152.152 144.993 1.00 16.85  ?  234  ILE   C C     1 
ATOM   645  O O     . ILE   A 1 234  ? 102.027 151.483 144.552 1.00 21.20  ?  234  ILE   C O     1 
ATOM   646  C CB    . ILE   A 1 234  ? 102.510 154.695 145.343 1.00 13.71  ?  234  ILE   C CB    1 
ATOM   647  C CG1   . ILE   A 1 234  ? 102.089 155.762 146.353 1.00 17.30  ?  234  ILE   C CG1   1 
ATOM   648  C CG2   . ILE   A 1 234  ? 101.655 154.765 144.094 1.00 18.82  ?  234  ILE   C CG2   1 
ATOM   649  C CD1   . ILE   A 1 234  ? 100.953 155.370 147.240 1.00 18.13  ?  234  ILE   C CD1   1 
ATOM   650  N N     . LEU   A 1 235  ? 104.159 151.823 144.825 1.00 16.88  ?  235  LEU   C N     1 
ATOM   651  C CA    . LEU   A 1 235  ? 104.530 150.691 143.959 1.00 17.80  ?  235  LEU   C CA    1 
ATOM   652  C C     . LEU   A 1 235  ? 104.099 149.352 144.553 1.00 19.93  ?  235  LEU   C C     1 
ATOM   653  O O     . LEU   A 1 235  ? 103.811 148.455 143.784 1.00 23.67  ?  235  LEU   C O     1 
ATOM   654  C CB    . LEU   A 1 235  ? 106.044 150.716 143.793 1.00 18.01  ?  235  LEU   C CB    1 
ATOM   655  C CG    . LEU   A 1 235  ? 106.690 149.573 143.021 1.00 22.71  ?  235  LEU   C CG    1 
ATOM   656  C CD1   . LEU   A 1 235  ? 107.397 150.109 141.795 1.00 26.93  ?  235  LEU   C CD1   1 
ATOM   657  C CD2   . LEU   A 1 235  ? 107.666 148.818 143.904 1.00 23.93  ?  235  LEU   C CD2   1 
ATOM   658  N N     . ALA   A 1 236  ? 104.141 149.180 145.850 1.00 18.45  ?  236  ALA   C N     1 
ATOM   659  C CA    . ALA   A 1 236  ? 103.843 147.865 146.407 1.00 17.39  ?  236  ALA   C CA    1 
ATOM   660  C C     . ALA   A 1 236  ? 102.344 147.716 146.361 1.00 22.18  ?  236  ALA   C C     1 
ATOM   661  O O     . ALA   A 1 236  ? 101.882 146.601 146.177 1.00 24.64  ?  236  ALA   C O     1 
ATOM   662  C CB    . ALA   A 1 236  ? 104.315 147.830 147.797 1.00 19.52  ?  236  ALA   C CB    1 
ATOM   663  N N     . ARG   A 1 237  ? 101.628 148.805 146.593 1.00 21.79  ?  237  ARG   C N     1 
ATOM   664  C CA    . ARG   A 1 237  ? 100.180 148.809 146.461 1.00 20.21  ?  237  ARG   C CA    1 
ATOM   665  C C     . ARG   A 1 237  ? 99.759  148.553 145.022 1.00 23.66  ?  237  ARG   C C     1 
ATOM   666  O O     . ARG   A 1 237  ? 98.769  147.863 144.767 1.00 26.95  ?  237  ARG   C O     1 
ATOM   667  C CB    . ARG   A 1 237  ? 99.613  150.128 146.943 1.00 20.44  ?  237  ARG   C CB    1 
ATOM   668  C CG    . ARG   A 1 237  ? 99.701  150.331 148.444 1.00 24.49  ?  237  ARG   C CG    1 
ATOM   669  C CD    . ARG   A 1 237  ? 99.228  151.672 148.849 1.00 26.29  ?  237  ARG   C CD    1 
ATOM   670  N NE    . ARG   A 1 237  ? 97.835  151.850 148.536 1.00 35.47  ?  237  ARG   C NE    1 
ATOM   671  C CZ    . ARG   A 1 237  ? 96.820  151.395 149.285 1.00 41.29  ?  237  ARG   C CZ    1 
ATOM   672  N NH1   . ARG   A 1 237  ? 97.061  150.732 150.397 1.00 42.17  1  237  ARG   C NH1   1 
ATOM   673  N NH2   . ARG   A 1 237  ? 95.583  151.609 148.898 1.00 43.54  ?  237  ARG   C NH2   1 
ATOM   674  N N     . LYS   A 1 238  ? 100.515 149.096 144.076 1.00 23.67  ?  238  LYS   C N     1 
ATOM   675  C CA    . LYS   A 1 238  ? 100.219 148.891 142.671 1.00 20.36  ?  238  LYS   C CA    1 
ATOM   676  C C     . LYS   A 1 238  ? 100.324 147.413 142.332 1.00 23.90  ?  238  LYS   C C     1 
ATOM   677  O O     . LYS   A 1 238  ? 99.465  146.876 141.638 1.00 28.28  ?  238  LYS   C O     1 
ATOM   678  C CB    . LYS   A 1 238  ? 101.165 149.712 141.794 1.00 22.64  ?  238  LYS   C CB    1 
ATOM   679  C CG    . LYS   A 1 238  ? 100.894 149.640 140.295 1.00 24.87  ?  238  LYS   C CG    1 
ATOM   680  C CD    . LYS   A 1 238  ? 99.568  150.300 139.933 1.00 31.47  ?  238  LYS   C CD    1 
ATOM   681  C CE    . LYS   A 1 238  ? 99.468  150.583 138.436 1.00 31.83  ?  238  LYS   C CE    1 
ATOM   682  N NZ    . LYS   A 1 238  ? 99.342  149.335 137.627 1.00 32.42  1  238  LYS   C NZ    1 
ATOM   683  N N     . MET   A 1 239  ? 101.350 146.742 142.853 1.00 22.81  ?  239  MET   C N     1 
ATOM   684  C CA    . MET   A 1 239  ? 101.497 145.312 142.612 1.00 22.89  ?  239  MET   C CA    1 
ATOM   685  C C     . MET   A 1 239  ? 100.313 144.532 143.151 1.00 25.67  ?  239  MET   C C     1 
ATOM   686  O O     . MET   A 1 239  ? 99.825  143.612 142.495 1.00 31.31  ?  239  MET   C O     1 
ATOM   687  C CB    . MET   A 1 239  ? 102.782 144.782 143.229 1.00 25.29  ?  239  MET   C CB    1 
ATOM   688  C CG    . MET   A 1 239  ? 104.030 145.190 142.493 1.00 27.42  ?  239  MET   C CG    1 
ATOM   689  S SD    . MET   A 1 239  ? 105.508 144.359 143.090 1.00 37.37  ?  239  MET   C SD    1 
ATOM   690  C CE    . MET   A 1 239  ? 105.840 145.289 144.571 1.00 31.59  ?  239  MET   C CE    1 
ATOM   691  N N     . MET   A 1 240  ? 99.829  144.903 144.333 1.00 25.67  ?  240  MET   C N     1 
ATOM   692  C CA    . MET   A 1 240  ? 98.678  144.212 144.896 1.00 26.04  ?  240  MET   C CA    1 
ATOM   693  C C     . MET   A 1 240  ? 97.479  144.334 143.973 1.00 28.25  ?  240  MET   C C     1 
ATOM   694  O O     . MET   A 1 240  ? 96.776  143.354 143.718 1.00 32.19  ?  240  MET   C O     1 
ATOM   695  C CB    . MET   A 1 240  ? 98.319  144.779 146.266 1.00 27.18  ?  240  MET   C CB    1 
ATOM   696  C CG    . MET   A 1 240  ? 99.279  144.428 147.375 1.00 25.93  ?  240  MET   C CG    1 
ATOM   697  S SD    . MET   A 1 240  ? 99.326  142.664 147.734 1.00 29.87  ?  240  MET   C SD    1 
ATOM   698  C CE    . MET   A 1 240  ? 97.733  142.366 148.491 1.00 33.80  ?  240  MET   C CE    1 
ATOM   699  N N     . LEU   A 1 241  ? 97.253  145.539 143.462 1.00 27.34  ?  241  LEU   C N     1 
ATOM   700  C CA    . LEU   A 1 241  ? 96.112  145.780 142.598 1.00 27.75  ?  241  LEU   C CA    1 
ATOM   701  C C     . LEU   A 1 241  ? 96.271  145.100 141.245 1.00 30.55  ?  241  LEU   C C     1 
ATOM   702  O O     . LEU   A 1 241  ? 95.337  144.463 140.759 1.00 35.75  ?  241  LEU   C O     1 
ATOM   703  C CB    . LEU   A 1 241  ? 95.911  147.289 142.405 1.00 25.18  ?  241  LEU   C CB    1 
ATOM   704  C CG    . LEU   A 1 241  ? 94.720  147.724 141.527 1.00 28.19  ?  241  LEU   C CG    1 
ATOM   705  C CD1   . LEU   A 1 241  ? 93.420  147.209 142.129 1.00 37.45  ?  241  LEU   C CD1   1 
ATOM   706  C CD2   . LEU   A 1 241  ? 94.700  149.244 141.437 1.00 30.36  ?  241  LEU   C CD2   1 
ATOM   707  N N     . ASP   A 1 242  ? 97.448  145.217 140.637 1.00 30.36  ?  242  ASP   C N     1 
ATOM   708  C CA    . ASP   A 1 242  ? 97.667  144.627 139.324 1.00 30.81  ?  242  ASP   C CA    1 
ATOM   709  C C     . ASP   A 1 242  ? 97.524  143.119 139.372 1.00 32.45  ?  242  ASP   C C     1 
ATOM   710  O O     . ASP   A 1 242  ? 96.968  142.506 138.462 1.00 38.68  ?  242  ASP   C O     1 
ATOM   711  C CB    . ASP   A 1 242  ? 99.044  144.993 138.775 1.00 33.73  ?  242  ASP   C CB    1 
ATOM   712  C CG    . ASP   A 1 242  ? 99.133  146.424 138.281 1.00 38.02  ?  242  ASP   C CG    1 
ATOM   713  O OD1   . ASP   A 1 242  ? 98.113  147.062 138.138 1.00 37.04  ?  242  ASP   C OD1   1 
ATOM   714  O OD2   . ASP   A 1 242  ? 100.224 146.885 138.024 1.00 40.35  -1 242  ASP   C OD2   1 
ATOM   715  N N     . TRP   A 1 243  ? 98.013  142.516 140.442 1.00 32.06  ?  243  TRP   C N     1 
ATOM   716  C CA    . TRP   A 1 243  ? 97.862  141.084 140.607 1.00 31.54  ?  243  TRP   C CA    1 
ATOM   717  C C     . TRP   A 1 243  ? 96.404  140.698 140.757 1.00 34.67  ?  243  TRP   C C     1 
ATOM   718  O O     . TRP   A 1 243  ? 95.917  139.799 140.069 1.00 39.20  ?  243  TRP   C O     1 
ATOM   719  C CB    . TRP   A 1 243  ? 98.653  140.622 141.811 1.00 31.47  ?  243  TRP   C CB    1 
ATOM   720  C CG    . TRP   A 1 243  ? 98.349  139.241 142.215 1.00 31.80  ?  243  TRP   C CG    1 
ATOM   721  C CD1   . TRP   A 1 243  ? 98.871  138.104 141.704 1.00 36.12  ?  243  TRP   C CD1   1 
ATOM   722  C CD2   . TRP   A 1 243  ? 97.465  138.838 143.271 1.00 32.80  ?  243  TRP   C CD2   1 
ATOM   723  N NE1   . TRP   A 1 243  ? 98.365  137.024 142.356 1.00 37.21  ?  243  TRP   C NE1   1 
ATOM   724  C CE2   . TRP   A 1 243  ? 97.489  137.455 143.307 1.00 34.86  ?  243  TRP   C CE2   1 
ATOM   725  C CE3   . TRP   A 1 243  ? 96.636  139.533 144.155 1.00 33.20  ?  243  TRP   C CE3   1 
ATOM   726  C CZ2   . TRP   A 1 243  ? 96.759  136.747 144.212 1.00 36.76  ?  243  TRP   C CZ2   1 
ATOM   727  C CZ3   . TRP   A 1 243  ? 95.893  138.816 145.068 1.00 36.49  ?  243  TRP   C CZ3   1 
ATOM   728  C CH2   . TRP   A 1 243  ? 95.942  137.456 145.086 1.00 38.60  ?  243  TRP   C CH2   1 
ATOM   729  N N     . ALA   A 1 244  ? 95.684  141.390 141.631 1.00 33.73  ?  244  ALA   C N     1 
ATOM   730  C CA    . ALA   A 1 244  ? 94.282  141.080 141.865 1.00 37.79  ?  244  ALA   C CA    1 
ATOM   731  C C     . ALA   A 1 244  ? 93.455  141.259 140.595 1.00 39.35  ?  244  ALA   C C     1 
ATOM   732  O O     . ALA   A 1 244  ? 92.488  140.534 140.366 1.00 42.58  ?  244  ALA   C O     1 
ATOM   733  C CB    . ALA   A 1 244  ? 93.735  141.939 142.978 1.00 39.39  ?  244  ALA   C CB    1 
ATOM   734  N N     . SER   A 1 245  ? 93.860  142.213 139.757 1.00 36.35  ?  245  SER   C N     1 
ATOM   735  C CA    . SER   A 1 245  ? 93.187  142.489 138.492 1.00 35.30  ?  245  SER   C CA    1 
ATOM   736  C C     . SER   A 1 245  ? 93.565  141.495 137.399 1.00 37.12  ?  245  SER   C C     1 
ATOM   737  O O     . SER   A 1 245  ? 93.003  141.534 136.304 1.00 40.46  ?  245  SER   C O     1 
ATOM   738  C CB    . SER   A 1 245  ? 93.503  143.898 138.031 1.00 35.35  ?  245  SER   C CB    1 
ATOM   739  O OG    . SER   A 1 245  ? 92.960  144.853 138.902 1.00 34.96  ?  245  SER   C OG    1 
ATOM   740  N N     . GLY   A 1 246  ? 94.518  140.611 137.686 1.00 37.59  ?  246  GLY   C N     1 
ATOM   741  C CA    . GLY   A 1 246  ? 94.951  139.605 136.726 1.00 40.37  ?  246  GLY   C CA    1 
ATOM   742  C C     . GLY   A 1 246  ? 95.891  140.147 135.653 1.00 42.91  ?  246  GLY   C C     1 
ATOM   743  O O     . GLY   A 1 246  ? 95.925  139.620 134.539 1.00 44.24  ?  246  GLY   C O     1 
ATOM   744  N N     . THR   A 1 247  ? 96.649  141.196 135.974 1.00 39.97  ?  247  THR   C N     1 
ATOM   745  C CA    . THR   A 1 247  ? 97.569  141.785 135.006 1.00 39.99  ?  247  THR   C CA    1 
ATOM   746  C C     . THR   A 1 247  ? 99.035  141.568 135.389 1.00 41.06  ?  247  THR   C C     1 
ATOM   747  O O     . THR   A 1 247  ? 99.934  142.084 134.725 1.00 45.82  ?  247  THR   C O     1 
ATOM   748  C CB    . THR   A 1 247  ? 97.305  143.291 134.832 1.00 39.25  ?  247  THR   C CB    1 
ATOM   749  O OG1   . THR   A 1 247  ? 97.509  143.960 136.075 1.00 40.71  ?  247  THR   C OG1   1 
ATOM   750  C CG2   . THR   A 1 247  ? 95.875  143.524 134.373 1.00 41.71  ?  247  THR   C CG2   1 
ATOM   751  N N     . LEU   A 1 248  ? 99.275  140.823 136.467 1.00 39.89  ?  248  LEU   C N     1 
ATOM   752  C CA    . LEU   A 1 248  ? 100.636 140.593 136.957 1.00 39.60  ?  248  LEU   C CA    1 
ATOM   753  C C     . LEU   A 1 248  ? 100.748 139.299 137.764 1.00 39.62  ?  248  LEU   C C     1 
ATOM   754  O O     . LEU   A 1 248  ? 99.968  139.068 138.686 1.00 40.49  ?  248  LEU   C O     1 
ATOM   755  C CB    . LEU   A 1 248  ? 101.073 141.791 137.813 1.00 40.35  ?  248  LEU   C CB    1 
ATOM   756  C CG    . LEU   A 1 248  ? 102.445 141.699 138.484 1.00 42.52  ?  248  LEU   C CG    1 
ATOM   757  C CD1   . LEU   A 1 248  ? 103.557 141.716 137.435 1.00 46.20  ?  248  LEU   C CD1   1 
ATOM   758  C CD2   . LEU   A 1 248  ? 102.591 142.857 139.458 1.00 41.30  ?  248  LEU   C CD2   1 
ATOM   759  N N     . TYR   A 1 249  ? 101.733 138.461 137.422 1.00 42.06  ?  249  TYR   C N     1 
ATOM   760  C CA    . TYR   A 1 249  ? 101.980 137.196 138.120 1.00 40.93  ?  249  TYR   C CA    1 
ATOM   761  C C     . TYR   A 1 249  ? 100.757 136.291 138.101 1.00 45.85  ?  249  TYR   C C     1 
ATOM   762  O O     . TYR   A 1 249  ? 100.522 135.537 139.049 1.00 44.71  ?  249  TYR   C O     1 
ATOM   763  C CB    . TYR   A 1 249  ? 102.365 137.426 139.587 1.00 41.97  ?  249  TYR   C CB    1 
ATOM   764  C CG    . TYR   A 1 249  ? 103.515 138.351 139.843 1.00 45.27  ?  249  TYR   C CG    1 
ATOM   765  C CD1   . TYR   A 1 249  ? 103.418 139.272 140.874 1.00 43.70  ?  249  TYR   C CD1   1 
ATOM   766  C CD2   . TYR   A 1 249  ? 104.658 138.299 139.068 1.00 47.48  ?  249  TYR   C CD2   1 
ATOM   767  C CE1   . TYR   A 1 249  ? 104.451 140.130 141.124 1.00 42.40  ?  249  TYR   C CE1   1 
ATOM   768  C CE2   . TYR   A 1 249  ? 105.696 139.165 139.328 1.00 45.56  ?  249  TYR   C CE2   1 
ATOM   769  C CZ    . TYR   A 1 249  ? 105.586 140.077 140.353 1.00 41.12  ?  249  TYR   C CZ    1 
ATOM   770  O OH    . TYR   A 1 249  ? 106.605 140.940 140.617 1.00 44.60  ?  249  TYR   C OH    1 
ATOM   771  N N     . GLN   A 1 250  ? 99.993  136.335 137.014 1.00 46.81  ?  250  GLN   C N     1 
ATOM   772  C CA    . GLN   A 1 250  ? 98.736  135.601 136.940 1.00 44.54  ?  250  GLN   C CA    1 
ATOM   773  C C     . GLN   A 1 250  ? 98.913  134.112 137.173 1.00 43.00  ?  250  GLN   C C     1 
ATOM   774  O O     . GLN   A 1 250  ? 98.041  133.462 137.747 1.00 49.68  ?  250  GLN   C O     1 
ATOM   775  C CB    . GLN   A 1 250  ? 98.084  135.803 135.573 1.00 46.95  ?  250  GLN   C CB    1 
ATOM   776  C CG    . GLN   A 1 250  ? 97.733  137.230 135.258 1.00 45.96  ?  250  GLN   C CG    1 
ATOM   777  C CD    . GLN   A 1 250  ? 98.848  137.939 134.517 1.00 49.17  ?  250  GLN   C CD    1 
ATOM   778  O OE1   . GLN   A 1 250  ? 100.026 137.609 134.690 1.00 49.11  ?  250  GLN   C OE1   1 
ATOM   779  N NE2   . GLN   A 1 250  ? 98.484  138.904 133.685 1.00 47.85  ?  250  GLN   C NE2   1 
ATOM   780  N N     . ASP   A 1 251  ? 100.029 133.567 136.716 1.00 41.36  ?  251  ASP   C N     1 
ATOM   781  C CA    . ASP   A 1 251  ? 100.288 132.147 136.848 1.00 48.46  ?  251  ASP   C CA    1 
ATOM   782  C C     . ASP   A 1 251  ? 101.479 131.863 137.745 1.00 47.26  ?  251  ASP   C C     1 
ATOM   783  O O     . ASP   A 1 251  ? 102.035 130.764 137.717 1.00 48.42  ?  251  ASP   C O     1 
ATOM   784  C CB    . ASP   A 1 251  ? 100.500 131.541 135.462 1.00 55.58  ?  251  ASP   C CB    1 
ATOM   785  C CG    . ASP   A 1 251  ? 101.637 132.213 134.706 1.00 57.34  ?  251  ASP   C CG    1 
ATOM   786  O OD1   . ASP   A 1 251  ? 102.051 133.280 135.118 1.00 51.21  ?  251  ASP   C OD1   1 
ATOM   787  O OD2   . ASP   A 1 251  ? 102.077 131.667 133.723 1.00 56.07  -1 251  ASP   C OD2   1 
ATOM   788  N N     . ARG   A 1 252  ? 101.877 132.850 138.542 1.00 45.46  ?  252  ARG   C N     1 
ATOM   789  C CA    . ARG   A 1 252  ? 103.043 132.686 139.393 1.00 44.20  ?  252  ARG   C CA    1 
ATOM   790  C C     . ARG   A 1 252  ? 102.671 132.607 140.864 1.00 43.46  ?  252  ARG   C C     1 
ATOM   791  O O     . ARG   A 1 252  ? 103.177 131.749 141.586 1.00 44.63  ?  252  ARG   C O     1 
ATOM   792  C CB    . ARG   A 1 252  ? 104.022 133.821 139.178 1.00 45.09  ?  252  ARG   C CB    1 
ATOM   793  C CG    . ARG   A 1 252  ? 105.365 133.641 139.846 1.00 47.60  ?  252  ARG   C CG    1 
ATOM   794  C CD    . ARG   A 1 252  ? 106.217 134.840 139.672 1.00 48.96  ?  252  ARG   C CD    1 
ATOM   795  N NE    . ARG   A 1 252  ? 106.510 135.121 138.278 1.00 52.22  ?  252  ARG   C NE    1 
ATOM   796  C CZ    . ARG   A 1 252  ? 107.474 134.529 137.548 1.00 55.74  ?  252  ARG   C CZ    1 
ATOM   797  N NH1   . ARG   A 1 252  ? 108.242 133.600 138.075 1.00 53.12  1  252  ARG   C NH1   1 
ATOM   798  N NH2   . ARG   A 1 252  ? 107.645 134.894 136.291 1.00 57.85  ?  252  ARG   C NH2   1 
ATOM   799  N N     . PHE   A 1 253  ? 101.787 133.492 141.317 1.00 43.40  ?  253  PHE   C N     1 
ATOM   800  C CA    . PHE   A 1 253  ? 101.417 133.478 142.727 1.00 44.68  ?  253  PHE   C CA    1 
ATOM   801  C C     . PHE   A 1 253  ? 99.919  133.323 142.917 1.00 45.51  ?  253  PHE   C C     1 
ATOM   802  O O     . PHE   A 1 253  ? 99.120  133.990 142.256 1.00 44.85  ?  253  PHE   C O     1 
ATOM   803  C CB    . PHE   A 1 253  ? 101.876 134.758 143.432 1.00 45.17  ?  253  PHE   C CB    1 
ATOM   804  C CG    . PHE   A 1 253  ? 103.348 134.974 143.380 1.00 41.98  ?  253  PHE   C CG    1 
ATOM   805  C CD1   . PHE   A 1 253  ? 103.872 136.041 142.688 1.00 39.61  ?  253  PHE   C CD1   1 
ATOM   806  C CD2   . PHE   A 1 253  ? 104.211 134.103 144.007 1.00 42.36  ?  253  PHE   C CD2   1 
ATOM   807  C CE1   . PHE   A 1 253  ? 105.226 136.238 142.623 1.00 38.45  ?  253  PHE   C CE1   1 
ATOM   808  C CE2   . PHE   A 1 253  ? 105.562 134.289 143.945 1.00 40.20  ?  253  PHE   C CE2   1 
ATOM   809  C CZ    . PHE   A 1 253  ? 106.077 135.362 143.249 1.00 38.07  ?  253  PHE   C CZ    1 
ATOM   810  N N     . ASP   A 1 254  ? 99.544  132.475 143.867 1.00 47.95  ?  254  ASP   C N     1 
ATOM   811  C CA    . ASP   A 1 254  ? 98.145  132.286 144.203 1.00 49.49  ?  254  ASP   C CA    1 
ATOM   812  C C     . ASP   A 1 254  ? 97.709  133.319 145.218 1.00 47.63  ?  254  ASP   C C     1 
ATOM   813  O O     . ASP   A 1 254  ? 96.543  133.712 145.250 1.00 48.11  ?  254  ASP   C O     1 
ATOM   814  C CB    . ASP   A 1 254  ? 97.893  130.880 144.747 1.00 54.10  ?  254  ASP   C CB    1 
ATOM   815  C CG    . ASP   A 1 254  ? 98.099  129.801 143.702 1.00 54.80  ?  254  ASP   C CG    1 
ATOM   816  O OD1   . ASP   A 1 254  ? 97.600  129.943 142.609 1.00 56.70  ?  254  ASP   C OD1   1 
ATOM   817  O OD2   . ASP   A 1 254  ? 98.750  128.835 144.002 1.00 52.87  -1 254  ASP   C OD2   1 
ATOM   818  N N     . TYR   A 1 255  ? 98.653  133.765 146.041 1.00 47.95  ?  255  TYR   C N     1 
ATOM   819  C CA    . TYR   A 1 255  ? 98.358  134.783 147.036 1.00 46.17  ?  255  TYR   C CA    1 
ATOM   820  C C     . TYR   A 1 255  ? 99.423  135.860 147.108 1.00 43.30  ?  255  TYR   C C     1 
ATOM   821  O O     . TYR   A 1 255  ? 100.618 135.580 146.987 1.00 43.09  ?  255  TYR   C O     1 
ATOM   822  C CB    . TYR   A 1 255  ? 98.244  134.162 148.418 1.00 49.50  ?  255  TYR   C CB    1 
ATOM   823  C CG    . TYR   A 1 255  ? 97.262  133.067 148.514 1.00 56.02  ?  255  TYR   C CG    1 
ATOM   824  C CD1   . TYR   A 1 255  ? 97.650  131.785 148.186 1.00 57.88  ?  255  TYR   C CD1   1 
ATOM   825  C CD2   . TYR   A 1 255  ? 95.979  133.325 148.937 1.00 56.02  ?  255  TYR   C CD2   1 
ATOM   826  C CE1   . TYR   A 1 255  ? 96.760  130.760 148.279 1.00 62.33  ?  255  TYR   C CE1   1 
ATOM   827  C CE2   . TYR   A 1 255  ? 95.083  132.300 149.031 1.00 60.42  ?  255  TYR   C CE2   1 
ATOM   828  C CZ    . TYR   A 1 255  ? 95.478  131.013 148.701 1.00 65.72  ?  255  TYR   C CZ    1 
ATOM   829  O OH    . TYR   A 1 255  ? 94.594  129.981 148.791 1.00 72.10  ?  255  TYR   C OH    1 
ATOM   830  N N     . LEU   A 1 256  ? 98.983  137.075 147.407 1.00 40.22  ?  256  LEU   C N     1 
ATOM   831  C CA    . LEU   A 1 256  ? 99.876  138.147 147.809 1.00 35.37  ?  256  LEU   C CA    1 
ATOM   832  C C     . LEU   A 1 256  ? 99.460  138.636 149.174 1.00 35.96  ?  256  LEU   C C     1 
ATOM   833  O O     . LEU   A 1 256  ? 98.316  139.049 149.365 1.00 38.79  ?  256  LEU   C O     1 
ATOM   834  C CB    . LEU   A 1 256  ? 99.851  139.333 146.844 1.00 30.58  ?  256  LEU   C CB    1 
ATOM   835  C CG    . LEU   A 1 256  ? 100.293 139.100 145.421 1.00 33.89  ?  256  LEU   C CG    1 
ATOM   836  C CD1   . LEU   A 1 256  ? 100.277 140.433 144.704 1.00 31.43  ?  256  LEU   C CD1   1 
ATOM   837  C CD2   . LEU   A 1 256  ? 101.653 138.488 145.403 1.00 34.65  ?  256  LEU   C CD2   1 
ATOM   838  N N     . PHE   A 1 257  ? 100.377 138.596 150.122 1.00 34.85  ?  257  PHE   C N     1 
ATOM   839  C CA    . PHE   A 1 257  ? 100.061 139.053 151.464 1.00 34.04  ?  257  PHE   C CA    1 
ATOM   840  C C     . PHE   A 1 257  ? 100.794 140.340 151.772 1.00 29.48  ?  257  PHE   C C     1 
ATOM   841  O O     . PHE   A 1 257  ? 102.022 140.363 151.864 1.00 29.50  ?  257  PHE   C O     1 
ATOM   842  C CB    . PHE   A 1 257  ? 100.389 137.977 152.493 1.00 36.22  ?  257  PHE   C CB    1 
ATOM   843  C CG    . PHE   A 1 257  ? 99.556  136.746 152.312 1.00 41.84  ?  257  PHE   C CG    1 
ATOM   844  C CD1   . PHE   A 1 257  ? 100.132 135.552 151.919 1.00 42.56  ?  257  PHE   C CD1   1 
ATOM   845  C CD2   . PHE   A 1 257  ? 98.179  136.782 152.519 1.00 45.87  ?  257  PHE   C CD2   1 
ATOM   846  C CE1   . PHE   A 1 257  ? 99.353  134.419 151.748 1.00 47.83  ?  257  PHE   C CE1   1 
ATOM   847  C CE2   . PHE   A 1 257  ? 97.410  135.655 152.344 1.00 45.29  ?  257  PHE   C CE2   1 
ATOM   848  C CZ    . PHE   A 1 257  ? 97.999  134.475 151.959 1.00 48.13  ?  257  PHE   C CZ    1 
ATOM   849  N N     . TYR   A 1 258  ? 100.038 141.418 151.903 1.00 27.07  ?  258  TYR   C N     1 
ATOM   850  C CA    . TYR   A 1 258  ? 100.625 142.726 152.129 1.00 21.76  ?  258  TYR   C CA    1 
ATOM   851  C C     . TYR   A 1 258  ? 100.853 142.971 153.607 1.00 25.60  ?  258  TYR   C C     1 
ATOM   852  O O     . TYR   A 1 258  ? 99.909  142.989 154.397 1.00 32.08  ?  258  TYR   C O     1 
ATOM   853  C CB    . TYR   A 1 258  ? 99.726  143.812 151.546 1.00 24.97  ?  258  TYR   C CB    1 
ATOM   854  C CG    . TYR   A 1 258  ? 100.234 145.205 151.766 1.00 26.20  ?  258  TYR   C CG    1 
ATOM   855  C CD1   . TYR   A 1 258  ? 101.301 145.677 151.026 1.00 25.05  ?  258  TYR   C CD1   1 
ATOM   856  C CD2   . TYR   A 1 258  ? 99.635  146.013 152.711 1.00 28.77  ?  258  TYR   C CD2   1 
ATOM   857  C CE1   . TYR   A 1 258  ? 101.767 146.953 151.235 1.00 26.08  ?  258  TYR   C CE1   1 
ATOM   858  C CE2   . TYR   A 1 258  ? 100.103 147.287 152.922 1.00 29.00  ?  258  TYR   C CE2   1 
ATOM   859  C CZ    . TYR   A 1 258  ? 101.165 147.758 152.189 1.00 26.30  ?  258  TYR   C CZ    1 
ATOM   860  O OH    . TYR   A 1 258  ? 101.633 149.032 152.408 1.00 26.92  ?  258  TYR   C OH    1 
ATOM   861  N N     . ILE   A 1 259  ? 102.109 143.169 153.975 1.00 25.67  ?  259  ILE   C N     1 
ATOM   862  C CA    . ILE   A 1 259  ? 102.483 143.414 155.355 1.00 24.94  ?  259  ILE   C CA    1 
ATOM   863  C C     . ILE   A 1 259  ? 102.862 144.870 155.535 1.00 23.68  ?  259  ILE   C C     1 
ATOM   864  O O     . ILE   A 1 259  ? 103.797 145.363 154.903 1.00 24.42  ?  259  ILE   C O     1 
ATOM   865  C CB    . ILE   A 1 259  ? 103.668 142.530 155.779 1.00 24.64  ?  259  ILE   C CB    1 
ATOM   866  C CG1   . ILE   A 1 259  ? 103.299 141.050 155.649 1.00 25.00  ?  259  ILE   C CG1   1 
ATOM   867  C CG2   . ILE   A 1 259  ? 104.091 142.877 157.208 1.00 27.48  ?  259  ILE   C CG2   1 
ATOM   868  C CD1   . ILE   A 1 259  ? 104.491 140.115 155.738 1.00 26.04  ?  259  ILE   C CD1   1 
ATOM   869  N N     . HIS   A 1 260  ? 102.145 145.556 156.403 1.00 25.49  ?  260  HIS   C N     1 
ATOM   870  C CA    . HIS   A 1 260  ? 102.418 146.957 156.643 1.00 27.40  ?  260  HIS   C CA    1 
ATOM   871  C C     . HIS   A 1 260  ? 103.295 147.071 157.885 1.00 30.98  ?  260  HIS   C C     1 
ATOM   872  O O     . HIS   A 1 260  ? 102.852 146.787 158.999 1.00 32.17  ?  260  HIS   C O     1 
ATOM   873  C CB    . HIS   A 1 260  ? 101.104 147.718 156.814 1.00 30.31  ?  260  HIS   C CB    1 
ATOM   874  C CG    . HIS   A 1 260  ? 101.219 149.194 156.708 1.00 34.06  ?  260  HIS   C CG    1 
ATOM   875  N ND1   . HIS   A 1 260  ? 100.252 150.045 157.199 1.00 41.50  ?  260  HIS   C ND1   1 
ATOM   876  C CD2   . HIS   A 1 260  ? 102.166 149.981 156.149 1.00 35.02  ?  260  HIS   C CD2   1 
ATOM   877  C CE1   . HIS   A 1 260  ? 100.599 151.290 156.954 1.00 47.44  ?  260  HIS   C CE1   1 
ATOM   878  N NE2   . HIS   A 1 260  ? 101.756 151.282 156.316 1.00 42.23  ?  260  HIS   C NE2   1 
ATOM   879  N N     . CYS   A 1 261  ? 104.556 147.434 157.694 1.00 28.84  ?  261  CYS   C N     1 
ATOM   880  C CA    . CYS   A 1 261  ? 105.526 147.380 158.780 1.00 27.19  ?  261  CYS   C CA    1 
ATOM   881  C C     . CYS   A 1 261  ? 105.270 148.404 159.872 1.00 27.28  ?  261  CYS   C C     1 
ATOM   882  O O     . CYS   A 1 261  ? 105.787 148.272 160.979 1.00 30.09  ?  261  CYS   C O     1 
ATOM   883  C CB    . CYS   A 1 261  ? 106.927 147.553 158.232 1.00 27.05  ?  261  CYS   C CB    1 
ATOM   884  S SG    . CYS   A 1 261  ? 107.484 146.157 157.253 1.00 28.89  ?  261  CYS   C SG    1 
ATOM   885  N N     . ARG   A 1 262  ? 104.438 149.395 159.579 1.00 28.80  ?  262  ARG   C N     1 
ATOM   886  C CA    . ARG   A 1 262  ? 104.088 150.404 160.568 1.00 29.04  ?  262  ARG   C CA    1 
ATOM   887  C C     . ARG   A 1 262  ? 103.013 149.887 161.515 1.00 32.89  ?  262  ARG   C C     1 
ATOM   888  O O     . ARG   A 1 262  ? 102.696 150.531 162.515 1.00 37.64  ?  262  ARG   C O     1 
ATOM   889  C CB    . ARG   A 1 262  ? 103.614 151.688 159.905 1.00 30.66  ?  262  ARG   C CB    1 
ATOM   890  C CG    . ARG   A 1 262  ? 104.685 152.401 159.116 1.00 38.71  ?  262  ARG   C CG    1 
ATOM   891  C CD    . ARG   A 1 262  ? 104.230 153.699 158.545 1.00 43.75  ?  262  ARG   C CD    1 
ATOM   892  N NE    . ARG   A 1 262  ? 103.244 153.546 157.501 1.00 45.87  ?  262  ARG   C NE    1 
ATOM   893  C CZ    . ARG   A 1 262  ? 102.623 154.560 156.874 1.00 57.74  ?  262  ARG   C CZ    1 
ATOM   894  N NH1   . ARG   A 1 262  ? 102.888 155.812 157.186 1.00 57.49  1  262  ARG   C NH1   1 
ATOM   895  N NH2   . ARG   A 1 262  ? 101.742 154.278 155.937 1.00 62.42  ?  262  ARG   C NH2   1 
ATOM   896  N N     . GLU   A 1 263  ? 102.449 148.726 161.190 1.00 32.04  ?  263  GLU   C N     1 
ATOM   897  C CA    . GLU   A 1 263  ? 101.423 148.108 162.016 1.00 33.71  ?  263  GLU   C CA    1 
ATOM   898  C C     . GLU   A 1 263  ? 102.011 146.967 162.834 1.00 32.21  ?  263  GLU   C C     1 
ATOM   899  O O     . GLU   A 1 263  ? 101.527 146.653 163.922 1.00 39.78  ?  263  GLU   C O     1 
ATOM   900  C CB    . GLU   A 1 263  ? 100.278 147.588 161.147 1.00 36.69  ?  263  GLU   C CB    1 
ATOM   901  C CG    . GLU   A 1 263  ? 99.552  148.664 160.367 1.00 39.61  ?  263  GLU   C CG    1 
ATOM   902  C CD    . GLU   A 1 263  ? 98.468  148.116 159.477 1.00 43.28  ?  263  GLU   C CD    1 
ATOM   903  O OE1   . GLU   A 1 263  ? 98.016  147.024 159.724 1.00 42.30  ?  263  GLU   C OE1   1 
ATOM   904  O OE2   . GLU   A 1 263  ? 98.107  148.786 158.536 1.00 44.15  -1 263  GLU   C OE2   1 
ATOM   905  N N     . VAL   A 1 264  ? 103.059 146.347 162.305 1.00 30.18  ?  264  VAL   C N     1 
ATOM   906  C CA    . VAL   A 1 264  ? 103.684 145.211 162.967 1.00 29.20  ?  264  VAL   C CA    1 
ATOM   907  C C     . VAL   A 1 264  ? 104.452 145.637 164.209 1.00 37.74  ?  264  VAL   C C     1 
ATOM   908  O O     . VAL   A 1 264  ? 105.280 146.544 164.161 1.00 40.59  ?  264  VAL   C O     1 
ATOM   909  C CB    . VAL   A 1 264  ? 104.647 144.490 162.003 1.00 31.16  ?  264  VAL   C CB    1 
ATOM   910  C CG1   . VAL   A 1 264  ? 105.393 143.373 162.730 1.00 37.74  ?  264  VAL   C CG1   1 
ATOM   911  C CG2   . VAL   A 1 264  ? 103.863 143.921 160.838 1.00 34.65  ?  264  VAL   C CG2   1 
ATOM   912  N N     . SER   A 1 265  ? 104.184 144.962 165.321 1.00 42.93  ?  265  SER   C N     1 
ATOM   913  C CA    . SER   A 1 265  ? 104.877 145.229 166.575 1.00 45.72  ?  265  SER   C CA    1 
ATOM   914  C C     . SER   A 1 265  ? 106.032 144.264 166.784 1.00 47.18  ?  265  SER   C C     1 
ATOM   915  O O     . SER   A 1 265  ? 105.875 143.055 166.636 1.00 48.12  ?  265  SER   C O     1 
ATOM   916  C CB    . SER   A 1 265  ? 103.925 145.117 167.743 1.00 48.68  ?  265  SER   C CB    1 
ATOM   917  O OG    . SER   A 1 265  ? 104.620 145.207 168.966 1.00 55.01  ?  265  SER   C OG    1 
ATOM   918  N N     . LEU   A 1 266  ? 107.184 144.803 167.162 1.00 48.92  ?  266  LEU   C N     1 
ATOM   919  C CA    . LEU   A 1 266  ? 108.371 143.996 167.420 1.00 51.50  ?  266  LEU   C CA    1 
ATOM   920  C C     . LEU   A 1 266  ? 108.413 143.509 168.865 1.00 52.15  ?  266  LEU   C C     1 
ATOM   921  O O     . LEU   A 1 266  ? 109.333 142.792 169.261 1.00 55.96  ?  266  LEU   C O     1 
ATOM   922  C CB    . LEU   A 1 266  ? 109.639 144.816 167.136 1.00 52.14  ?  266  LEU   C CB    1 
ATOM   923  C CG    . LEU   A 1 266  ? 109.837 145.323 165.695 1.00 40.55  ?  266  LEU   C CG    1 
ATOM   924  C CD1   . LEU   A 1 266  ? 111.082 146.210 165.661 1.00 36.65  ?  266  LEU   C CD1   1 
ATOM   925  C CD2   . LEU   A 1 266  ? 109.988 144.142 164.745 1.00 42.99  ?  266  LEU   C CD2   1 
ATOM   926  N N     . VAL   A 1 267  ? 107.433 143.930 169.654 1.00 55.27  ?  267  VAL   C N     1 
ATOM   927  C CA    . VAL   A 1 267  ? 107.372 143.576 171.065 1.00 60.29  ?  267  VAL   C CA    1 
ATOM   928  C C     . VAL   A 1 267  ? 106.268 142.564 171.333 1.00 59.38  ?  267  VAL   C C     1 
ATOM   929  O O     . VAL   A 1 267  ? 106.433 141.650 172.140 1.00 60.94  ?  267  VAL   C O     1 
ATOM   930  C CB    . VAL   A 1 267  ? 107.155 144.834 171.923 1.00 62.64  ?  267  VAL   C CB    1 
ATOM   931  C CG1   . VAL   A 1 267  ? 106.987 144.452 173.386 1.00 64.76  ?  267  VAL   C CG1   1 
ATOM   932  C CG2   . VAL   A 1 267  ? 108.346 145.759 171.750 1.00 61.92  ?  267  VAL   C CG2   1 
ATOM   933  N N     . THR   A 1 268  ? 105.126 142.767 170.693 1.00 58.24  ?  268  THR   C N     1 
ATOM   934  C CA    . THR   A 1 268  ? 103.955 141.927 170.901 1.00 60.64  ?  268  THR   C CA    1 
ATOM   935  C C     . THR   A 1 268  ? 104.225 140.496 170.435 1.00 61.75  ?  268  THR   C C     1 
ATOM   936  O O     . THR   A 1 268  ? 104.808 140.284 169.372 1.00 59.79  ?  268  THR   C O     1 
ATOM   937  C CB    . THR   A 1 268  ? 102.740 142.499 170.151 1.00 60.36  ?  268  THR   C CB    1 
ATOM   938  O OG1   . THR   A 1 268  ? 102.516 143.852 170.569 1.00 58.47  ?  268  THR   C OG1   1 
ATOM   939  C CG2   . THR   A 1 268  ? 101.502 141.680 170.456 1.00 66.92  ?  268  THR   C CG2   1 
ATOM   940  N N     . GLN   A 1 269  ? 103.803 139.522 171.242 1.00 65.06  ?  269  GLN   C N     1 
ATOM   941  C CA    . GLN   A 1 269  ? 103.984 138.108 170.921 1.00 65.29  ?  269  GLN   C CA    1 
ATOM   942  C C     . GLN   A 1 269  ? 102.783 137.517 170.187 1.00 66.04  ?  269  GLN   C C     1 
ATOM   943  O O     . GLN   A 1 269  ? 101.678 137.467 170.729 1.00 68.84  ?  269  GLN   C O     1 
ATOM   944  C CB    . GLN   A 1 269  ? 104.229 137.307 172.201 1.00 66.67  ?  269  GLN   C CB    1 
ATOM   945  C CG    . GLN   A 1 269  ? 104.432 135.835 171.964 1.00 70.12  ?  269  GLN   C CG    1 
ATOM   946  C CD    . GLN   A 1 269  ? 104.742 135.069 173.214 1.00 76.93  ?  269  GLN   C CD    1 
ATOM   947  O OE1   . GLN   A 1 269  ? 104.607 135.589 174.324 1.00 72.38  ?  269  GLN   C OE1   1 
ATOM   948  N NE2   . GLN   A 1 269  ? 105.162 133.818 173.053 1.00 79.40  ?  269  GLN   C NE2   1 
ATOM   949  N N     . ARG   A 1 270  ? 103.004 137.077 168.950 1.00 64.19  ?  270  ARG   C N     1 
ATOM   950  C CA    . ARG   A 1 270  ? 101.935 136.532 168.116 1.00 66.60  ?  270  ARG   C CA    1 
ATOM   951  C C     . ARG   A 1 270  ? 102.416 135.417 167.198 1.00 66.12  ?  270  ARG   C C     1 
ATOM   952  O O     . ARG   A 1 270  ? 103.583 135.368 166.810 1.00 63.88  ?  270  ARG   C O     1 
ATOM   953  C CB    . ARG   A 1 270  ? 101.297 137.617 167.251 1.00 61.85  ?  270  ARG   C CB    1 
ATOM   954  C CG    . ARG   A 1 270  ? 100.538 138.704 167.993 1.00 64.17  ?  270  ARG   C CG    1 
ATOM   955  C CD    . ARG   A 1 270  ? 99.266  138.192 168.580 1.00 70.18  ?  270  ARG   C CD    1 
ATOM   956  N NE    . ARG   A 1 270  ? 98.474  139.252 169.186 1.00 78.07  ?  270  ARG   C NE    1 
ATOM   957  C CZ    . ARG   A 1 270  ? 98.607  139.693 170.459 1.00 81.44  ?  270  ARG   C CZ    1 
ATOM   958  N NH1   . ARG   A 1 270  ? 99.505  139.163 171.267 1.00 75.26  1  270  ARG   C NH1   1 
ATOM   959  N NH2   . ARG   A 1 270  ? 97.827  140.665 170.895 1.00 82.07  ?  270  ARG   C NH2   1 
ATOM   960  N N     . SER   A 1 271  ? 101.491 134.544 166.822 1.00 69.15  ?  271  SER   C N     1 
ATOM   961  C CA    . SER   A 1 271  ? 101.726 133.526 165.808 1.00 69.42  ?  271  SER   C CA    1 
ATOM   962  C C     . SER   A 1 271  ? 101.549 134.172 164.452 1.00 64.81  ?  271  SER   C C     1 
ATOM   963  O O     . SER   A 1 271  ? 101.255 135.367 164.370 1.00 61.52  ?  271  SER   C O     1 
ATOM   964  C CB    . SER   A 1 271  ? 100.765 132.369 165.982 1.00 69.00  ?  271  SER   C CB    1 
ATOM   965  O OG    . SER   A 1 271  ? 99.450  132.764 165.696 1.00 70.66  ?  271  SER   C OG    1 
ATOM   966  N N     . LEU   A 1 272  ? 101.728 133.421 163.378 1.00 65.09  ?  272  LEU   C N     1 
ATOM   967  C CA    . LEU   A 1 272  ? 101.594 134.022 162.061 1.00 62.60  ?  272  LEU   C CA    1 
ATOM   968  C C     . LEU   A 1 272  ? 100.116 134.155 161.704 1.00 62.39  ?  272  LEU   C C     1 
ATOM   969  O O     . LEU   A 1 272  ? 99.612  133.489 160.794 1.00 59.67  ?  272  LEU   C O     1 
ATOM   970  C CB    . LEU   A 1 272  ? 102.307 133.157 161.026 1.00 61.27  ?  272  LEU   C CB    1 
ATOM   971  C CG    . LEU   A 1 272  ? 102.517 133.760 159.636 1.00 61.51  ?  272  LEU   C CG    1 
ATOM   972  C CD1   . LEU   A 1 272  ? 103.530 134.898 159.702 1.00 66.91  ?  272  LEU   C CD1   1 
ATOM   973  C CD2   . LEU   A 1 272  ? 102.990 132.670 158.709 1.00 60.26  ?  272  LEU   C CD2   1 
ATOM   974  N N     . GLY   A 1 273  ? 99.424  135.018 162.444 1.00 62.02  ?  273  GLY   C N     1 
ATOM   975  C CA    . GLY   A 1 273  ? 97.995  135.250 162.292 1.00 60.52  ?  273  GLY   C CA    1 
ATOM   976  C C     . GLY   A 1 273  ? 97.740  136.528 161.516 1.00 63.19  ?  273  GLY   C C     1 
ATOM   977  O O     . GLY   A 1 273  ? 96.596  136.949 161.334 1.00 64.03  ?  273  GLY   C O     1 
ATOM   978  N N     . ASP   A 1 274  ? 98.818  137.137 161.043 1.00 61.68  ?  274  ASP   C N     1 
ATOM   979  C CA    . ASP   A 1 274  ? 98.739  138.355 160.262 1.00 62.28  ?  274  ASP   C CA    1 
ATOM   980  C C     . ASP   A 1 274  ? 98.075  138.051 158.934 1.00 59.70  ?  274  ASP   C C     1 
ATOM   981  O O     . ASP   A 1 274  ? 97.381  138.889 158.368 1.00 59.78  ?  274  ASP   C O     1 
ATOM   982  C CB    . ASP   A 1 274  ? 100.137 138.930 160.067 1.00 65.76  ?  274  ASP   C CB    1 
ATOM   983  C CG    . ASP   A 1 274  ? 101.085 137.912 159.472 1.00 62.30  ?  274  ASP   C CG    1 
ATOM   984  O OD1   . ASP   A 1 274  ? 100.659 136.800 159.239 1.00 62.25  ?  274  ASP   C OD1   1 
ATOM   985  O OD2   . ASP   A 1 274  ? 102.228 138.238 159.266 1.00 52.10  -1 274  ASP   C OD2   1 
ATOM   986  N N     . LEU   A 1 275  ? 98.215  136.806 158.503 1.00 58.21  ?  275  LEU   C N     1 
ATOM   987  C CA    . LEU   A 1 275  ? 97.579  136.301 157.295 1.00 55.85  ?  275  LEU   C CA    1 
ATOM   988  C C     . LEU   A 1 275  ? 96.062  136.397 157.387 1.00 59.62  ?  275  LEU   C C     1 
ATOM   989  O O     . LEU   A 1 275  ? 95.373  136.413 156.366 1.00 59.62  ?  275  LEU   C O     1 
ATOM   990  C CB    . LEU   A 1 275  ? 97.971  134.836 157.082 1.00 55.91  ?  275  LEU   C CB    1 
ATOM   991  C CG    . LEU   A 1 275  ? 99.427  134.556 156.722 1.00 54.08  ?  275  LEU   C CG    1 
ATOM   992  C CD1   . LEU   A 1 275  ? 99.673  133.064 156.801 1.00 59.17  ?  275  LEU   C CD1   1 
ATOM   993  C CD2   . LEU   A 1 275  ? 99.697  135.053 155.330 1.00 53.72  ?  275  LEU   C CD2   1 
ATOM   994  N N     . ILE   A 1 276  ? 95.538  136.439 158.606 1.00 61.49  ?  276  ILE   C N     1 
ATOM   995  C CA    . ILE   A 1 276  ? 94.107  136.536 158.811 1.00 65.43  ?  276  ILE   C CA    1 
ATOM   996  C C     . ILE   A 1 276  ? 93.694  137.994 158.785 1.00 64.68  ?  276  ILE   C C     1 
ATOM   997  O O     . ILE   A 1 276  ? 92.762  138.377 158.085 1.00 65.07  ?  276  ILE   C O     1 
ATOM   998  C CB    . ILE   A 1 276  ? 93.705  135.921 160.157 1.00 68.19  ?  276  ILE   C CB    1 
ATOM   999  C CG1   . ILE   A 1 276  ? 94.060  134.431 160.157 1.00 70.62  ?  276  ILE   C CG1   1 
ATOM   1000 C CG2   . ILE   A 1 276  ? 92.205  136.151 160.409 1.00 73.79  ?  276  ILE   C CG2   1 
ATOM   1001 C CD1   . ILE   A 1 276  ? 93.993  133.779 161.511 1.00 73.69  ?  276  ILE   C CD1   1 
ATOM   1002 N N     . MET   A 1 277  ? 94.400  138.808 159.559 1.00 63.97  ?  277  MET   C N     1 
ATOM   1003 C CA    . MET   A 1 277  ? 94.058  140.218 159.686 1.00 66.30  ?  277  MET   C CA    1 
ATOM   1004 C C     . MET   A 1 277  ? 94.354  140.999 158.410 1.00 63.31  ?  277  MET   C C     1 
ATOM   1005 O O     . MET   A 1 277  ? 93.711  142.011 158.130 1.00 63.72  ?  277  MET   C O     1 
ATOM   1006 C CB    . MET   A 1 277  ? 94.802  140.828 160.871 1.00 72.88  ?  277  MET   C CB    1 
ATOM   1007 C CG    . MET   A 1 277  ? 94.321  140.328 162.241 1.00 84.79  ?  277  MET   C CG    1 
ATOM   1008 S SD    . MET   A 1 277  ? 92.534  140.529 162.498 1.00 83.98  ?  277  MET   C SD    1 
ATOM   1009 C CE    . MET   A 1 277  ? 92.361  142.314 162.550 1.00 56.95  ?  277  MET   C CE    1 
ATOM   1010 N N     . SER   A 1 278  ? 95.318  140.520 157.631 1.00 61.97  ?  278  SER   C N     1 
ATOM   1011 C CA    . SER   A 1 278  ? 95.739  141.174 156.401 1.00 62.81  ?  278  SER   C CA    1 
ATOM   1012 C C     . SER   A 1 278  ? 94.869  140.823 155.206 1.00 61.07  ?  278  SER   C C     1 
ATOM   1013 O O     . SER   A 1 278  ? 95.122  141.303 154.098 1.00 63.24  ?  278  SER   C O     1 
ATOM   1014 C CB    . SER   A 1 278  ? 97.169  140.802 156.077 1.00 61.59  ?  278  SER   C CB    1 
ATOM   1015 O OG    . SER   A 1 278  ? 97.261  139.454 155.710 1.00 57.75  ?  278  SER   C OG    1 
ATOM   1016 N N     . CYS   A 1 279  ? 93.872  139.967 155.400 1.00 62.47  ?  279  CYS   C N     1 
ATOM   1017 C CA    . CYS   A 1 279  ? 93.050  139.570 154.274 1.00 63.31  ?  279  CYS   C CA    1 
ATOM   1018 C C     . CYS   A 1 279  ? 91.595  139.949 154.493 1.00 64.74  ?  279  CYS   C C     1 
ATOM   1019 O O     . CYS   A 1 279  ? 91.291  141.042 154.969 1.00 66.42  ?  279  CYS   C O     1 
ATOM   1020 C CB    . CYS   A 1 279  ? 93.176  138.065 154.009 1.00 62.99  ?  279  CYS   C CB    1 
ATOM   1021 S SG    . CYS   A 1 279  ? 92.439  136.999 155.276 1.00 60.66  ?  279  CYS   C SG    1 
ATOM   1022 N N     . CYS   A 1 280  ? 90.701  139.059 154.105 1.00 63.25  ?  280  CYS   C N     1 
ATOM   1023 C CA    . CYS   A 1 280  ? 89.282  139.324 154.168 1.00 64.87  ?  280  CYS   C CA    1 
ATOM   1024 C C     . CYS   A 1 280  ? 88.811  139.409 155.622 1.00 70.94  ?  280  CYS   C C     1 
ATOM   1025 O O     . CYS   A 1 280  ? 89.498  138.926 156.521 1.00 69.66  ?  280  CYS   C O     1 
ATOM   1026 C CB    . CYS   A 1 280  ? 88.538  138.219 153.425 1.00 67.64  ?  280  CYS   C CB    1 
ATOM   1027 S SG    . CYS   A 1 280  ? 88.894  138.198 151.665 1.00 69.94  ?  280  CYS   C SG    1 
ATOM   1028 N N     . PRO   A 1 281  ? 87.636  140.009 155.873 1.00 73.40  ?  281  PRO   C N     1 
ATOM   1029 C CA    . PRO   A 1 281  ? 86.952  140.093 157.158 1.00 74.16  ?  281  PRO   C CA    1 
ATOM   1030 C C     . PRO   A 1 281  ? 86.744  138.739 157.836 1.00 75.99  ?  281  PRO   C C     1 
ATOM   1031 O O     . PRO   A 1 281  ? 86.547  138.677 159.048 1.00 71.24  ?  281  PRO   C O     1 
ATOM   1032 C CB    . PRO   A 1 281  ? 85.613  140.724 156.770 1.00 74.91  ?  281  PRO   C CB    1 
ATOM   1033 C CG    . PRO   A 1 281  ? 85.918  141.542 155.545 1.00 76.39  ?  281  PRO   C CG    1 
ATOM   1034 C CD    . PRO   A 1 281  ? 86.952  140.750 154.788 1.00 67.09  ?  281  PRO   C CD    1 
ATOM   1035 N N     . ASP   A 1 282  ? 86.768  137.661 157.060 1.00 74.08  ?  282  ASP   C N     1 
ATOM   1036 C CA    . ASP   A 1 282  ? 86.572  136.325 157.608 1.00 75.43  ?  282  ASP   C CA    1 
ATOM   1037 C C     . ASP   A 1 282  ? 87.639  136.030 158.665 1.00 92.32  ?  282  ASP   C C     1 
ATOM   1038 O O     . ASP   A 1 282  ? 88.825  135.981 158.338 1.00 81.30  ?  282  ASP   C O     1 
ATOM   1039 C CB    . ASP   A 1 282  ? 86.657  135.274 156.497 1.00 78.32  ?  282  ASP   C CB    1 
ATOM   1040 C CG    . ASP   A 1 282  ? 86.334  133.849 156.974 1.00 83.66  ?  282  ASP   C CG    1 
ATOM   1041 O OD1   . ASP   A 1 282  ? 86.362  133.608 158.162 1.00 77.14  ?  282  ASP   C OD1   1 
ATOM   1042 O OD2   . ASP   A 1 282  ? 86.060  133.019 156.138 1.00 90.74  -1 282  ASP   C OD2   1 
ATOM   1043 N N     . PRO   A 1 283  ? 87.256  135.843 159.936 1.00 78.11  ?  283  PRO   C N     1 
ATOM   1044 C CA    . PRO   A 1 283  ? 88.140  135.638 161.065 1.00 83.20  ?  283  PRO   C CA    1 
ATOM   1045 C C     . PRO   A 1 283  ? 88.799  134.265 161.047 1.00 82.20  ?  283  PRO   C C     1 
ATOM   1046 O O     . PRO   A 1 283  ? 89.741  134.023 161.801 1.00 82.25  ?  283  PRO   C O     1 
ATOM   1047 C CB    . PRO   A 1 283  ? 87.191  135.810 162.260 1.00 85.01  ?  283  PRO   C CB    1 
ATOM   1048 C CG    . PRO   A 1 283  ? 85.831  135.415 161.734 1.00 84.52  ?  283  PRO   C CG    1 
ATOM   1049 C CD    . PRO   A 1 283  ? 85.823  135.841 160.280 1.00 81.50  ?  283  PRO   C CD    1 
ATOM   1050 N N     . ASN   A 1 284  ? 88.292  133.359 160.211 1.00 86.78  ?  284  ASN   C N     1 
ATOM   1051 C CA    . ASN   A 1 284  ? 88.809  131.996 160.179 1.00 80.65  ?  284  ASN   C CA    1 
ATOM   1052 C C     . ASN   A 1 284  ? 89.001  131.450 158.762 1.00 79.24  ?  284  ASN   C C     1 
ATOM   1053 O O     . ASN   A 1 284  ? 88.308  130.510 158.370 1.00 82.22  ?  284  ASN   C O     1 
ATOM   1054 C CB    . ASN   A 1 284  ? 87.900  131.067 160.958 1.00 87.84  ?  284  ASN   C CB    1 
ATOM   1055 C CG    . ASN   A 1 284  ? 87.799  131.446 162.396 1.00 87.26  ?  284  ASN   C CG    1 
ATOM   1056 O OD1   . ASN   A 1 284  ? 88.743  131.252 163.168 1.00 87.25  ?  284  ASN   C OD1   1 
ATOM   1057 N ND2   . ASN   A 1 284  ? 86.671  131.978 162.780 1.00 86.51  ?  284  ASN   C ND2   1 
ATOM   1058 N N     . PRO   A 1 285  ? 89.940  132.004 157.990 1.00 77.37  ?  285  PRO   C N     1 
ATOM   1059 C CA    . PRO   A 1 285  ? 90.322  131.579 156.661 1.00 74.03  ?  285  PRO   C CA    1 
ATOM   1060 C C     . PRO   A 1 285  ? 91.060  130.248 156.760 1.00 70.54  ?  285  PRO   C C     1 
ATOM   1061 O O     . PRO   A 1 285  ? 91.590  129.912 157.821 1.00 70.33  ?  285  PRO   C O     1 
ATOM   1062 C CB    . PRO   A 1 285  ? 91.230  132.723 156.203 1.00 74.89  ?  285  PRO   C CB    1 
ATOM   1063 C CG    . PRO   A 1 285  ? 91.795  133.278 157.471 1.00 76.30  ?  285  PRO   C CG    1 
ATOM   1064 C CD    . PRO   A 1 285  ? 90.693  133.147 158.490 1.00 77.91  ?  285  PRO   C CD    1 
ATOM   1065 N N     . PRO   A 1 286  ? 91.150  129.502 155.661 1.00 68.65  ?  286  PRO   C N     1 
ATOM   1066 C CA    . PRO   A 1 286  ? 91.760  128.190 155.549 1.00 72.17  ?  286  PRO   C CA    1 
ATOM   1067 C C     . PRO   A 1 286  ? 93.282  128.230 155.576 1.00 68.65  ?  286  PRO   C C     1 
ATOM   1068 O O     . PRO   A 1 286  ? 93.939  127.820 154.625 1.00 68.98  ?  286  PRO   C O     1 
ATOM   1069 C CB    . PRO   A 1 286  ? 91.231  127.726 154.190 1.00 71.85  ?  286  PRO   C CB    1 
ATOM   1070 C CG    . PRO   A 1 286  ? 91.058  128.998 153.401 1.00 69.39  ?  286  PRO   C CG    1 
ATOM   1071 C CD    . PRO   A 1 286  ? 90.567  130.006 154.406 1.00 66.65  ?  286  PRO   C CD    1 
ATOM   1072 N N     . ILE   A 1 287  ? 93.837  128.698 156.688 1.00 70.93  ?  287  ILE   C N     1 
ATOM   1073 C CA    . ILE   A 1 287  ? 95.285  128.849 156.847 1.00 73.82  ?  287  ILE   C CA    1 
ATOM   1074 C C     . ILE   A 1 287  ? 96.004  127.511 156.727 1.00 73.45  ?  287  ILE   C C     1 
ATOM   1075 O O     . ILE   A 1 287  ? 97.145  127.444 156.270 1.00 71.26  ?  287  ILE   C O     1 
ATOM   1076 C CB    . ILE   A 1 287  ? 95.633  129.502 158.203 1.00 78.27  ?  287  ILE   C CB    1 
ATOM   1077 C CG1   . ILE   A 1 287  ? 95.026  130.933 158.293 1.00 78.08  ?  287  ILE   C CG1   1 
ATOM   1078 C CG2   . ILE   A 1 287  ? 97.148  129.552 158.400 1.00 79.11  ?  287  ILE   C CG2   1 
ATOM   1079 C CD1   . ILE   A 1 287  ? 95.503  131.928 157.231 1.00 75.36  ?  287  ILE   C CD1   1 
ATOM   1080 N N     . HIS   A 1 288  ? 95.360  126.455 157.201 1.00 74.05  ?  288  HIS   C N     1 
ATOM   1081 C CA    . HIS   A 1 288  ? 95.937  125.120 157.229 1.00 71.72  ?  288  HIS   C CA    1 
ATOM   1082 C C     . HIS   A 1 288  ? 95.857  124.374 155.899 1.00 69.24  ?  288  HIS   C C     1 
ATOM   1083 O O     . HIS   A 1 288  ? 96.359  123.255 155.792 1.00 66.20  ?  288  HIS   C O     1 
ATOM   1084 C CB    . HIS   A 1 288  ? 95.228  124.306 158.299 1.00 69.62  ?  288  HIS   C CB    1 
ATOM   1085 C CG    . HIS   A 1 288  ? 93.761  124.247 158.071 1.00 81.89  ?  288  HIS   C CG    1 
ATOM   1086 N ND1   . HIS   A 1 288  ? 92.948  125.360 158.187 1.00 79.92  ?  288  HIS   C ND1   1 
ATOM   1087 C CD2   . HIS   A 1 288  ? 92.947  123.221 157.732 1.00 88.80  ?  288  HIS   C CD2   1 
ATOM   1088 C CE1   . HIS   A 1 288  ? 91.699  125.016 157.930 1.00 85.25  ?  288  HIS   C CE1   1 
ATOM   1089 N NE2   . HIS   A 1 288  ? 91.671  123.724 157.653 1.00 91.95  ?  288  HIS   C NE2   1 
ATOM   1090 N N     . LYS   A 1 289  ? 95.206  124.960 154.895 1.00 69.55  ?  289  LYS   C N     1 
ATOM   1091 C CA    . LYS   A 1 289  ? 95.032  124.260 153.627 1.00 70.50  ?  289  LYS   C CA    1 
ATOM   1092 C C     . LYS   A 1 289  ? 96.188  124.540 152.663 1.00 68.40  ?  289  LYS   C C     1 
ATOM   1093 O O     . LYS   A 1 289  ? 97.331  124.711 153.085 1.00 67.02  ?  289  LYS   C O     1 
ATOM   1094 C CB    . LYS   A 1 289  ? 93.690  124.632 152.982 1.00 73.34  ?  289  LYS   C CB    1 
ATOM   1095 C CG    . LYS   A 1 289  ? 92.452  124.189 153.770 1.00 84.36  ?  289  LYS   C CG    1 
ATOM   1096 C CD    . LYS   A 1 289  ? 91.173  124.370 152.936 1.00 94.55  ?  289  LYS   C CD    1 
ATOM   1097 C CE    . LYS   A 1 289  ? 89.921  124.011 153.728 1.00 91.57  ?  289  LYS   C CE    1 
ATOM   1098 N NZ    . LYS   A 1 289  ? 88.677  124.239 152.935 1.00 87.46  1  289  LYS   C NZ    1 
ATOM   1099 N N     . ILE   A 1 290  ? 95.899  124.564 151.360 1.00 74.20  ?  290  ILE   C N     1 
ATOM   1100 C CA    . ILE   A 1 290  ? 96.933  124.693 150.333 1.00 76.85  ?  290  ILE   C CA    1 
ATOM   1101 C C     . ILE   A 1 290  ? 97.665  126.026 150.436 1.00 71.81  ?  290  ILE   C C     1 
ATOM   1102 O O     . ILE   A 1 290  ? 98.783  126.172 149.952 1.00 69.23  ?  290  ILE   C O     1 
ATOM   1103 C CB    . ILE   A 1 290  ? 96.330  124.509 148.918 1.00 83.65  ?  290  ILE   C CB    1 
ATOM   1104 C CG1   . ILE   A 1 290  ? 97.441  124.196 147.871 1.00 88.48  ?  290  ILE   C CG1   1 
ATOM   1105 C CG2   . ILE   A 1 290  ? 95.543  125.758 148.499 1.00 84.14  ?  290  ILE   C CG2   1 
ATOM   1106 C CD1   . ILE   A 1 290  ? 98.124  122.841 148.047 1.00 67.25  ?  290  ILE   C CD1   1 
ATOM   1107 N N     . VAL   A 1 291  ? 97.038  126.989 151.098 1.00 70.76  ?  291  VAL   C N     1 
ATOM   1108 C CA    . VAL   A 1 291  ? 97.649  128.286 151.359 1.00 64.10  ?  291  VAL   C CA    1 
ATOM   1109 C C     . VAL   A 1 291  ? 98.884  128.140 152.252 1.00 62.44  ?  291  VAL   C C     1 
ATOM   1110 O O     . VAL   A 1 291  ? 99.697  129.052 152.359 1.00 64.88  ?  291  VAL   C O     1 
ATOM   1111 C CB    . VAL   A 1 291  ? 96.621  129.224 152.005 1.00 59.55  ?  291  VAL   C CB    1 
ATOM   1112 C CG1   . VAL   A 1 291  ? 96.345  128.780 153.397 1.00 62.80  ?  291  VAL   C CG1   1 
ATOM   1113 C CG2   . VAL   A 1 291  ? 97.140  130.660 152.003 1.00 61.01  ?  291  VAL   C CG2   1 
ATOM   1114 N N     . ARG   A 1 292  ? 99.016  126.994 152.906 1.00 65.74  ?  292  ARG   C N     1 
ATOM   1115 C CA    . ARG   A 1 292  ? 100.182 126.712 153.725 1.00 65.17  ?  292  ARG   C CA    1 
ATOM   1116 C C     . ARG   A 1 292  ? 101.385 126.337 152.860 1.00 69.25  ?  292  ARG   C C     1 
ATOM   1117 O O     . ARG   A 1 292  ? 102.520 126.309 153.343 1.00 68.78  ?  292  ARG   C O     1 
ATOM   1118 C CB    . ARG   A 1 292  ? 99.879  125.579 154.692 1.00 69.55  ?  292  ARG   C CB    1 
ATOM   1119 C CG    . ARG   A 1 292  ? 100.986 125.250 155.692 1.00 70.32  ?  292  ARG   C CG    1 
ATOM   1120 C CD    . ARG   A 1 292  ? 100.563 124.186 156.647 1.00 72.83  ?  292  ARG   C CD    1 
ATOM   1121 N NE    . ARG   A 1 292  ? 100.329 122.906 155.974 1.00 72.29  ?  292  ARG   C NE    1 
ATOM   1122 C CZ    . ARG   A 1 292  ? 99.772  121.815 156.547 1.00 54.05  ?  292  ARG   C CZ    1 
ATOM   1123 N NH1   . ARG   A 1 292  ? 99.391  121.843 157.808 1.00 58.89  1  292  ARG   C NH1   1 
ATOM   1124 N NH2   . ARG   A 1 292  ? 99.610  120.714 155.838 1.00 51.32  ?  292  ARG   C NH2   1 
ATOM   1125 N N     . LYS   A 1 293  ? 101.136 126.004 151.593 1.00 68.46  ?  293  LYS   C N     1 
ATOM   1126 C CA    . LYS   A 1 293  ? 102.184 125.541 150.693 1.00 70.47  ?  293  LYS   C CA    1 
ATOM   1127 C C     . LYS   A 1 293  ? 102.963 126.704 150.061 1.00 67.18  ?  293  LYS   C C     1 
ATOM   1128 O O     . LYS   A 1 293  ? 102.366 127.586 149.448 1.00 63.69  ?  293  LYS   C O     1 
ATOM   1129 C CB    . LYS   A 1 293  ? 101.579 124.674 149.584 1.00 73.00  ?  293  LYS   C CB    1 
ATOM   1130 C CG    . LYS   A 1 293  ? 102.597 124.071 148.620 1.00 71.35  ?  293  LYS   C CG    1 
ATOM   1131 C CD    . LYS   A 1 293  ? 101.927 123.229 147.555 1.00 62.56  ?  293  LYS   C CD    1 
ATOM   1132 C CE    . LYS   A 1 293  ? 102.947 122.732 146.537 1.00 64.32  ?  293  LYS   C CE    1 
ATOM   1133 N NZ    . LYS   A 1 293  ? 102.321 121.872 145.485 1.00 97.28  1  293  LYS   C NZ    1 
ATOM   1134 N N     . PRO   A 1 294  ? 104.299 126.696 150.163 1.00 65.76  ?  294  PRO   C N     1 
ATOM   1135 C CA    . PRO   A 1 294  ? 105.220 127.680 149.624 1.00 61.05  ?  294  PRO   C CA    1 
ATOM   1136 C C     . PRO   A 1 294  ? 105.352 127.538 148.115 1.00 57.16  ?  294  PRO   C C     1 
ATOM   1137 O O     . PRO   A 1 294  ? 104.750 126.653 147.518 1.00 59.06  ?  294  PRO   C O     1 
ATOM   1138 C CB    . PRO   A 1 294  ? 106.516 127.345 150.354 1.00 57.58  ?  294  PRO   C CB    1 
ATOM   1139 C CG    . PRO   A 1 294  ? 106.434 125.867 150.619 1.00 67.14  ?  294  PRO   C CG    1 
ATOM   1140 C CD    . PRO   A 1 294  ? 104.968 125.601 150.892 1.00 71.53  ?  294  PRO   C CD    1 
ATOM   1141 N N     . SER   A 1 295  ? 106.117 128.449 147.509 1.00 55.45  ?  295  SER   C N     1 
ATOM   1142 C CA    . SER   A 1 295  ? 106.370 128.514 146.066 1.00 53.69  ?  295  SER   C CA    1 
ATOM   1143 C C     . SER   A 1 295  ? 105.246 129.193 145.283 1.00 53.29  ?  295  SER   C C     1 
ATOM   1144 O O     . SER   A 1 295  ? 105.447 129.609 144.142 1.00 51.35  ?  295  SER   C O     1 
ATOM   1145 C CB    . SER   A 1 295  ? 106.610 127.132 145.492 1.00 59.62  ?  295  SER   C CB    1 
ATOM   1146 O OG    . SER   A 1 295  ? 105.407 126.503 145.158 1.00 62.95  ?  295  SER   C OG    1 
ATOM   1147 N N     . ARG   A 1 296  ? 104.072 129.332 145.898 1.00 52.01  ?  296  ARG   C N     1 
ATOM   1148 C CA    . ARG   A 1 296  ? 102.937 129.984 145.251 1.00 50.35  ?  296  ARG   C CA    1 
ATOM   1149 C C     . ARG   A 1 296  ? 102.463 131.201 146.029 1.00 48.05  ?  296  ARG   C C     1 
ATOM   1150 O O     . ARG   A 1 296  ? 101.397 131.759 145.749 1.00 46.59  ?  296  ARG   C O     1 
ATOM   1151 C CB    . ARG   A 1 296  ? 101.784 129.010 145.086 1.00 54.04  ?  296  ARG   C CB    1 
ATOM   1152 C CG    . ARG   A 1 296  ? 102.091 127.771 144.249 1.00 49.50  ?  296  ARG   C CG    1 
ATOM   1153 C CD    . ARG   A 1 296  ? 102.256 128.101 142.801 1.00 51.10  ?  296  ARG   C CD    1 
ATOM   1154 N NE    . ARG   A 1 296  ? 101.030 128.651 142.235 1.00 48.56  ?  296  ARG   C NE    1 
ATOM   1155 C CZ    . ARG   A 1 296  ? 100.920 129.213 141.011 1.00 47.70  ?  296  ARG   C CZ    1 
ATOM   1156 N NH1   . ARG   A 1 296  ? 101.971 129.296 140.224 1.00 48.72  1  296  ARG   C NH1   1 
ATOM   1157 N NH2   . ARG   A 1 296  ? 99.748  129.681 140.610 1.00 47.46  ?  296  ARG   C NH2   1 
ATOM   1158 N N     . ILE   A 1 297  ? 103.246 131.603 147.021 1.00 48.27  ?  297  ILE   C N     1 
ATOM   1159 C CA    . ILE   A 1 297  ? 102.894 132.741 147.853 1.00 47.17  ?  297  ILE   C CA    1 
ATOM   1160 C C     . ILE   A 1 297  ? 103.996 133.774 147.920 1.00 43.63  ?  297  ILE   C C     1 
ATOM   1161 O O     . ILE   A 1 297  ? 105.153 133.444 148.195 1.00 44.73  ?  297  ILE   C O     1 
ATOM   1162 C CB    . ILE   A 1 297  ? 102.536 132.291 149.274 1.00 49.52  ?  297  ILE   C CB    1 
ATOM   1163 C CG1   . ILE   A 1 297  ? 101.329 131.377 149.204 1.00 55.69  ?  297  ILE   C CG1   1 
ATOM   1164 C CG2   . ILE   A 1 297  ? 102.274 133.503 150.148 1.00 41.94  ?  297  ILE   C CG2   1 
ATOM   1165 C CD1   . ILE   A 1 297  ? 100.985 130.698 150.480 1.00 58.57  ?  297  ILE   C CD1   1 
ATOM   1166 N N     . LEU   A 1 298  ? 103.624 135.027 147.698 1.00 40.32  ?  298  LEU   C N     1 
ATOM   1167 C CA    . LEU   A 1 298  ? 104.556 136.130 147.828 1.00 35.67  ?  298  LEU   C CA    1 
ATOM   1168 C C     . LEU   A 1 298  ? 104.129 137.080 148.934 1.00 33.00  ?  298  LEU   C C     1 
ATOM   1169 O O     . LEU   A 1 298  ? 103.003 137.576 148.954 1.00 32.26  ?  298  LEU   C O     1 
ATOM   1170 C CB    . LEU   A 1 298  ? 104.688 136.877 146.494 1.00 36.35  ?  298  LEU   C CB    1 
ATOM   1171 C CG    . LEU   A 1 298  ? 105.388 138.249 146.532 1.00 30.24  ?  298  LEU   C CG    1 
ATOM   1172 C CD1   . LEU   A 1 298  ? 106.815 138.071 146.954 1.00 32.48  ?  298  LEU   C CD1   1 
ATOM   1173 C CD2   . LEU   A 1 298  ? 105.328 138.887 145.146 1.00 31.98  ?  298  LEU   C CD2   1 
ATOM   1174 N N     . PHE   A 1 299  ? 105.053 137.343 149.842 1.00 32.42  ?  299  PHE   C N     1 
ATOM   1175 C CA    . PHE   A 1 299  ? 104.828 138.293 150.916 1.00 29.32  ?  299  PHE   C CA    1 
ATOM   1176 C C     . PHE   A 1 299  ? 105.419 139.639 150.535 1.00 26.18  ?  299  PHE   C C     1 
ATOM   1177 O O     . PHE   A 1 299  ? 106.545 139.707 150.048 1.00 28.80  ?  299  PHE   C O     1 
ATOM   1178 C CB    . PHE   A 1 299  ? 105.503 137.811 152.196 1.00 29.81  ?  299  PHE   C CB    1 
ATOM   1179 C CG    . PHE   A 1 299  ? 104.892 136.615 152.815 1.00 36.09  ?  299  PHE   C CG    1 
ATOM   1180 C CD1   . PHE   A 1 299  ? 105.308 135.348 152.454 1.00 40.25  ?  299  PHE   C CD1   1 
ATOM   1181 C CD2   . PHE   A 1 299  ? 103.920 136.746 153.778 1.00 34.34  ?  299  PHE   C CD2   1 
ATOM   1182 C CE1   . PHE   A 1 299  ? 104.754 134.236 153.049 1.00 43.77  ?  299  PHE   C CE1   1 
ATOM   1183 C CE2   . PHE   A 1 299  ? 103.370 135.647 154.375 1.00 38.72  ?  299  PHE   C CE2   1 
ATOM   1184 C CZ    . PHE   A 1 299  ? 103.784 134.385 154.011 1.00 43.71  ?  299  PHE   C CZ    1 
ATOM   1185 N N     . LEU   A 1 300  ? 104.680 140.711 150.783 1.00 25.25  ?  300  LEU   C N     1 
ATOM   1186 C CA    . LEU   A 1 300  ? 105.221 142.040 150.539 1.00 21.40  ?  300  LEU   C CA    1 
ATOM   1187 C C     . LEU   A 1 300  ? 105.457 142.738 151.868 1.00 23.29  ?  300  LEU   C C     1 
ATOM   1188 O O     . LEU   A 1 300  ? 104.513 143.101 152.562 1.00 23.65  ?  300  LEU   C O     1 
ATOM   1189 C CB    . LEU   A 1 300  ? 104.259 142.888 149.692 1.00 21.78  ?  300  LEU   C CB    1 
ATOM   1190 C CG    . LEU   A 1 300  ? 103.771 142.277 148.360 1.00 23.69  ?  300  LEU   C CG    1 
ATOM   1191 C CD1   . LEU   A 1 300  ? 102.845 143.269 147.679 1.00 26.61  ?  300  LEU   C CD1   1 
ATOM   1192 C CD2   . LEU   A 1 300  ? 104.940 141.944 147.466 1.00 27.48  ?  300  LEU   C CD2   1 
ATOM   1193 N N     . MET   A 1 301  ? 106.725 142.911 152.227 1.00 23.51  ?  301  MET   C N     1 
ATOM   1194 C CA    . MET   A 1 301  ? 107.070 143.545 153.492 1.00 21.54  ?  301  MET   C CA    1 
ATOM   1195 C C     . MET   A 1 301  ? 107.360 145.015 153.266 1.00 20.75  ?  301  MET   C C     1 
ATOM   1196 O O     . MET   A 1 301  ? 108.461 145.388 152.866 1.00 21.34  ?  301  MET   C O     1 
ATOM   1197 C CB    . MET   A 1 301  ? 108.261 142.856 154.133 1.00 22.15  ?  301  MET   C CB    1 
ATOM   1198 C CG    . MET   A 1 301  ? 108.626 143.439 155.458 1.00 31.30  ?  301  MET   C CG    1 
ATOM   1199 S SD    . MET   A 1 301  ? 109.928 142.564 156.283 1.00 43.37  ?  301  MET   C SD    1 
ATOM   1200 C CE    . MET   A 1 301  ? 109.956 143.496 157.804 1.00 37.26  ?  301  MET   C CE    1 
ATOM   1201 N N     . ASP   A 1 302  ? 106.344 145.843 153.465 1.00 20.76  ?  302  ASP   C N     1 
ATOM   1202 C CA    . ASP   A 1 302  ? 106.438 147.230 153.061 1.00 19.35  ?  302  ASP   C CA    1 
ATOM   1203 C C     . ASP   A 1 302  ? 106.900 148.156 154.184 1.00 24.73  ?  302  ASP   C C     1 
ATOM   1204 O O     . ASP   A 1 302  ? 106.141 148.444 155.113 1.00 27.24  ?  302  ASP   C O     1 
ATOM   1205 C CB    . ASP   A 1 302  ? 105.089 147.706 152.523 1.00 21.51  ?  302  ASP   C CB    1 
ATOM   1206 C CG    . ASP   A 1 302  ? 105.149 149.079 151.867 1.00 21.50  ?  302  ASP   C CG    1 
ATOM   1207 O OD1   . ASP   A 1 302  ? 106.235 149.580 151.668 1.00 21.73  ?  302  ASP   C OD1   1 
ATOM   1208 O OD2   . ASP   A 1 302  ? 104.105 149.618 151.572 1.00 23.99  -1 302  ASP   C OD2   1 
ATOM   1209 N N     . GLY   A 1 303  ? 108.149 148.623 154.105 1.00 25.10  ?  303  GLY   C N     1 
ATOM   1210 C CA    . GLY   A 1 303  ? 108.676 149.553 155.099 1.00 22.71  ?  303  GLY   C CA    1 
ATOM   1211 C C     . GLY   A 1 303  ? 109.522 148.896 156.184 1.00 22.39  ?  303  GLY   C C     1 
ATOM   1212 O O     . GLY   A 1 303  ? 109.309 149.141 157.367 1.00 25.59  ?  303  GLY   C O     1 
ATOM   1213 N N     . PHE   A 1 304  ? 110.512 148.104 155.798 1.00 20.06  ?  304  PHE   C N     1 
ATOM   1214 C CA    . PHE   A 1 304  ? 111.390 147.484 156.792 1.00 19.87  ?  304  PHE   C CA    1 
ATOM   1215 C C     . PHE   A 1 304  ? 111.935 148.533 157.760 1.00 20.62  ?  304  PHE   C C     1 
ATOM   1216 O O     . PHE   A 1 304  ? 111.984 148.322 158.970 1.00 23.50  ?  304  PHE   C O     1 
ATOM   1217 C CB    . PHE   A 1 304  ? 112.550 146.750 156.119 1.00 20.39  ?  304  PHE   C CB    1 
ATOM   1218 C CG    . PHE   A 1 304  ? 113.536 146.155 157.084 1.00 22.76  ?  304  PHE   C CG    1 
ATOM   1219 C CD1   . PHE   A 1 304  ? 113.289 144.943 157.690 1.00 24.12  ?  304  PHE   C CD1   1 
ATOM   1220 C CD2   . PHE   A 1 304  ? 114.715 146.816 157.387 1.00 24.13  ?  304  PHE   C CD2   1 
ATOM   1221 C CE1   . PHE   A 1 304  ? 114.185 144.397 158.581 1.00 28.43  ?  304  PHE   C CE1   1 
ATOM   1222 C CE2   . PHE   A 1 304  ? 115.618 146.276 158.277 1.00 28.22  ?  304  PHE   C CE2   1 
ATOM   1223 C CZ    . PHE   A 1 304  ? 115.350 145.061 158.876 1.00 31.28  ?  304  PHE   C CZ    1 
ATOM   1224 N N     . ASP   A 1 305  ? 112.343 149.672 157.220 1.00 20.26  ?  305  ASP   C N     1 
ATOM   1225 C CA    . ASP   A 1 305  ? 112.916 150.754 158.008 1.00 21.88  ?  305  ASP   C CA    1 
ATOM   1226 C C     . ASP   A 1 305  ? 111.895 151.442 158.903 1.00 21.30  ?  305  ASP   C C     1 
ATOM   1227 O O     . ASP   A 1 305  ? 112.261 152.209 159.794 1.00 23.62  ?  305  ASP   C O     1 
ATOM   1228 C CB    . ASP   A 1 305  ? 113.548 151.788 157.086 1.00 20.00  ?  305  ASP   C CB    1 
ATOM   1229 C CG    . ASP   A 1 305  ? 112.585 152.317 156.082 1.00 19.74  ?  305  ASP   C CG    1 
ATOM   1230 O OD1   . ASP   A 1 305  ? 112.324 151.604 155.143 1.00 18.80  ?  305  ASP   C OD1   1 
ATOM   1231 O OD2   . ASP   A 1 305  ? 112.119 153.415 156.229 1.00 22.00  -1 305  ASP   C OD2   1 
ATOM   1232 N N     . GLU   A 1 306  ? 110.618 151.195 158.651 1.00 21.83  ?  306  GLU   C N     1 
ATOM   1233 C CA    . GLU   A 1 306  ? 109.556 151.832 159.407 1.00 23.60  ?  306  GLU   C CA    1 
ATOM   1234 C C     . GLU   A 1 306  ? 109.129 150.993 160.605 1.00 25.01  ?  306  GLU   C C     1 
ATOM   1235 O O     . GLU   A 1 306  ? 108.245 151.398 161.363 1.00 26.32  ?  306  GLU   C O     1 
ATOM   1236 C CB    . GLU   A 1 306  ? 108.356 152.120 158.511 1.00 25.83  ?  306  GLU   C CB    1 
ATOM   1237 C CG    . GLU   A 1 306  ? 108.610 153.161 157.426 1.00 30.22  ?  306  GLU   C CG    1 
ATOM   1238 C CD    . GLU   A 1 306  ? 107.436 153.346 156.502 1.00 42.53  ?  306  GLU   C CD    1 
ATOM   1239 O OE1   . GLU   A 1 306  ? 106.632 152.453 156.413 1.00 38.43  ?  306  GLU   C OE1   1 
ATOM   1240 O OE2   . GLU   A 1 306  ? 107.344 154.380 155.883 1.00 49.17  -1 306  GLU   C OE2   1 
ATOM   1241 N N     . LEU   A 1 307  ? 109.754 149.831 160.786 1.00 23.98  ?  307  LEU   C N     1 
ATOM   1242 C CA    . LEU   A 1 307  ? 109.436 149.012 161.943 1.00 23.99  ?  307  LEU   C CA    1 
ATOM   1243 C C     . LEU   A 1 307  ? 109.777 149.806 163.188 1.00 25.70  ?  307  LEU   C C     1 
ATOM   1244 O O     . LEU   A 1 307  ? 110.884 150.326 163.311 1.00 27.77  ?  307  LEU   C O     1 
ATOM   1245 C CB    . LEU   A 1 307  ? 110.255 147.717 161.933 1.00 23.16  ?  307  LEU   C CB    1 
ATOM   1246 C CG    . LEU   A 1 307  ? 109.938 146.694 160.841 1.00 24.22  ?  307  LEU   C CG    1 
ATOM   1247 C CD1   . LEU   A 1 307  ? 111.056 145.661 160.804 1.00 26.92  ?  307  LEU   C CD1   1 
ATOM   1248 C CD2   . LEU   A 1 307  ? 108.593 146.018 161.135 1.00 31.22  ?  307  LEU   C CD2   1 
ATOM   1249 N N     . GLN   A 1 308  ? 108.840 149.903 164.114 1.00 27.60  ?  308  GLN   C N     1 
ATOM   1250 C CA    . GLN   A 1 308  ? 109.071 150.695 165.310 1.00 24.77  ?  308  GLN   C CA    1 
ATOM   1251 C C     . GLN   A 1 308  ? 109.669 149.880 166.440 1.00 29.53  ?  308  GLN   C C     1 
ATOM   1252 O O     . GLN   A 1 308  ? 109.147 148.828 166.809 1.00 35.48  ?  308  GLN   C O     1 
ATOM   1253 C CB    . GLN   A 1 308  ? 107.770 151.354 165.750 1.00 26.56  ?  308  GLN   C CB    1 
ATOM   1254 C CG    . GLN   A 1 308  ? 107.230 152.323 164.738 1.00 28.02  ?  308  GLN   C CG    1 
ATOM   1255 C CD    . GLN   A 1 308  ? 108.186 153.465 164.504 1.00 32.42  ?  308  GLN   C CD    1 
ATOM   1256 O OE1   . GLN   A 1 308  ? 108.381 154.317 165.369 1.00 33.02  ?  308  GLN   C OE1   1 
ATOM   1257 N NE2   . GLN   A 1 308  ? 108.800 153.486 163.333 1.00 34.08  ?  308  GLN   C NE2   1 
ATOM   1258 N N     . GLY   A 1 309  ? 110.753 150.392 167.009 1.00 29.97  ?  309  GLY   C N     1 
ATOM   1259 C CA    . GLY   A 1 309  ? 111.424 149.734 168.118 1.00 29.90  ?  309  GLY   C CA    1 
ATOM   1260 C C     . GLY   A 1 309  ? 112.733 149.101 167.680 1.00 29.70  ?  309  GLY   C C     1 
ATOM   1261 O O     . GLY   A 1 309  ? 113.012 148.973 166.489 1.00 32.64  ?  309  GLY   C O     1 
ATOM   1262 N N     . ALA   A 1 310  ? 113.551 148.717 168.648 1.00 30.62  ?  310  ALA   C N     1 
ATOM   1263 C CA    . ALA   A 1 310  ? 114.844 148.130 168.344 1.00 32.27  ?  310  ALA   C CA    1 
ATOM   1264 C C     . ALA   A 1 310  ? 114.674 146.803 167.637 1.00 32.56  ?  310  ALA   C C     1 
ATOM   1265 O O     . ALA   A 1 310  ? 113.737 146.054 167.916 1.00 38.72  ?  310  ALA   C O     1 
ATOM   1266 C CB    . ALA   A 1 310  ? 115.657 147.944 169.612 1.00 38.06  ?  310  ALA   C CB    1 
ATOM   1267 N N     . PHE   A 1 311  ? 115.585 146.513 166.724 1.00 31.16  ?  311  PHE   C N     1 
ATOM   1268 C CA    . PHE   A 1 311  ? 115.552 145.265 165.989 1.00 35.00  ?  311  PHE   C CA    1 
ATOM   1269 C C     . PHE   A 1 311  ? 116.923 144.605 166.005 1.00 40.47  ?  311  PHE   C C     1 
ATOM   1270 O O     . PHE   A 1 311  ? 117.908 145.201 165.566 1.00 41.81  ?  311  PHE   C O     1 
ATOM   1271 C CB    . PHE   A 1 311  ? 115.116 145.520 164.547 1.00 34.65  ?  311  PHE   C CB    1 
ATOM   1272 C CG    . PHE   A 1 311  ? 114.853 144.282 163.759 1.00 34.66  ?  311  PHE   C CG    1 
ATOM   1273 C CD1   . PHE   A 1 311  ? 113.557 143.859 163.538 1.00 36.49  ?  311  PHE   C CD1   1 
ATOM   1274 C CD2   . PHE   A 1 311  ? 115.892 143.533 163.245 1.00 37.98  ?  311  PHE   C CD2   1 
ATOM   1275 C CE1   . PHE   A 1 311  ? 113.302 142.715 162.819 1.00 39.34  ?  311  PHE   C CE1   1 
ATOM   1276 C CE2   . PHE   A 1 311  ? 115.643 142.390 162.533 1.00 40.27  ?  311  PHE   C CE2   1 
ATOM   1277 C CZ    . PHE   A 1 311  ? 114.345 141.977 162.317 1.00 41.40  ?  311  PHE   C CZ    1 
ATOM   1278 N N     . ASP   A 1 312  ? 116.982 143.375 166.499 1.00 42.74  ?  312  ASP   C N     1 
ATOM   1279 C CA    . ASP   A 1 312  ? 118.226 142.617 166.529 1.00 46.64  ?  312  ASP   C CA    1 
ATOM   1280 C C     . ASP   A 1 312  ? 118.334 141.719 165.307 1.00 48.82  ?  312  ASP   C C     1 
ATOM   1281 O O     . ASP   A 1 312  ? 117.511 140.826 165.112 1.00 48.98  ?  312  ASP   C O     1 
ATOM   1282 C CB    . ASP   A 1 312  ? 118.319 141.776 167.802 1.00 51.08  ?  312  ASP   C CB    1 
ATOM   1283 C CG    . ASP   A 1 312  ? 118.520 142.618 169.057 1.00 57.47  ?  312  ASP   C CG    1 
ATOM   1284 O OD1   . ASP   A 1 312  ? 119.155 143.642 168.972 1.00 54.47  ?  312  ASP   C OD1   1 
ATOM   1285 O OD2   . ASP   A 1 312  ? 118.030 142.228 170.088 1.00 62.07  -1 312  ASP   C OD2   1 
ATOM   1286 N N     . GLU   A 1 313  ? 119.337 141.965 164.473 1.00 49.02  ?  313  GLU   C N     1 
ATOM   1287 C CA    . GLU   A 1 313  ? 119.509 141.200 163.245 1.00 51.06  ?  313  GLU   C CA    1 
ATOM   1288 C C     . GLU   A 1 313  ? 120.144 139.833 163.511 1.00 55.93  ?  313  GLU   C C     1 
ATOM   1289 O O     . GLU   A 1 313  ? 120.160 138.967 162.634 1.00 53.26  ?  313  GLU   C O     1 
ATOM   1290 C CB    . GLU   A 1 313  ? 120.337 142.001 162.230 1.00 49.69  ?  313  GLU   C CB    1 
ATOM   1291 C CG    . GLU   A 1 313  ? 121.811 142.146 162.570 1.00 53.57  ?  313  GLU   C CG    1 
ATOM   1292 C CD    . GLU   A 1 313  ? 122.105 143.284 163.509 1.00 55.81  ?  313  GLU   C CD    1 
ATOM   1293 O OE1   . GLU   A 1 313  ? 121.196 143.752 164.148 1.00 53.03  ?  313  GLU   C OE1   1 
ATOM   1294 O OE2   . GLU   A 1 313  ? 123.240 143.687 163.589 1.00 54.82  -1 313  GLU   C OE2   1 
ATOM   1295 N N     . HIS   A 1 314  ? 120.653 139.639 164.727 1.00 57.05  ?  314  HIS   C N     1 
ATOM   1296 C CA    . HIS   A 1 314  ? 121.276 138.377 165.110 1.00 53.98  ?  314  HIS   C CA    1 
ATOM   1297 C C     . HIS   A 1 314  ? 120.520 137.731 166.263 1.00 58.54  ?  314  HIS   C C     1 
ATOM   1298 O O     . HIS   A 1 314  ? 120.646 138.144 167.417 1.00 56.33  ?  314  HIS   C O     1 
ATOM   1299 C CB    . HIS   A 1 314  ? 122.740 138.573 165.515 1.00 56.34  ?  314  HIS   C CB    1 
ATOM   1300 C CG    . HIS   A 1 314  ? 123.639 139.041 164.408 1.00 60.19  ?  314  HIS   C CG    1 
ATOM   1301 N ND1   . HIS   A 1 314  ? 123.991 138.239 163.340 1.00 60.95  ?  314  HIS   C ND1   1 
ATOM   1302 C CD2   . HIS   A 1 314  ? 124.270 140.220 164.214 1.00 61.73  ?  314  HIS   C CD2   1 
ATOM   1303 C CE1   . HIS   A 1 314  ? 124.791 138.915 162.532 1.00 57.07  ?  314  HIS   C CE1   1 
ATOM   1304 N NE2   . HIS   A 1 314  ? 124.976 140.115 163.040 1.00 58.43  ?  314  HIS   C NE2   1 
ATOM   1305 N N     . ILE   A 1 315  ? 119.714 136.728 165.936 1.00 63.60  ?  315  ILE   C N     1 
ATOM   1306 C CA    . ILE   A 1 315  ? 118.869 136.054 166.915 1.00 67.13  ?  315  ILE   C CA    1 
ATOM   1307 C C     . ILE   A 1 315  ? 119.171 134.563 167.013 1.00 68.04  ?  315  ILE   C C     1 
ATOM   1308 O O     . ILE   A 1 315  ? 119.142 133.844 166.014 1.00 64.80  ?  315  ILE   C O     1 
ATOM   1309 C CB    . ILE   A 1 315  ? 117.383 136.261 166.571 1.00 63.54  ?  315  ILE   C CB    1 
ATOM   1310 C CG1   . ILE   A 1 315  ? 117.041 137.766 166.665 1.00 58.68  ?  315  ILE   C CG1   1 
ATOM   1311 C CG2   . ILE   A 1 315  ? 116.497 135.414 167.478 1.00 63.24  ?  315  ILE   C CG2   1 
ATOM   1312 C CD1   . ILE   A 1 315  ? 115.670 138.136 166.132 1.00 61.40  ?  315  ILE   C CD1   1 
ATOM   1313 N N     . GLY   A 1 316  ? 119.433 134.109 168.232 1.00 63.89  ?  316  GLY   C N     1 
ATOM   1314 C CA    . GLY   A 1 316  ? 119.666 132.699 168.526 1.00 67.33  ?  316  GLY   C CA    1 
ATOM   1315 C C     . GLY   A 1 316  ? 118.416 131.843 168.288 1.00 67.12  ?  316  GLY   C C     1 
ATOM   1316 O O     . GLY   A 1 316  ? 118.396 130.995 167.393 1.00 62.08  ?  316  GLY   C O     1 
ATOM   1317 N N     . PRO   A 1 317  ? 117.364 132.040 169.091 1.00 67.54  ?  317  PRO   C N     1 
ATOM   1318 C CA    . PRO   A 1 317  ? 116.090 131.351 169.030 1.00 69.48  ?  317  PRO   C CA    1 
ATOM   1319 C C     . PRO   A 1 317  ? 115.223 131.870 167.891 1.00 63.45  ?  317  PRO   C C     1 
ATOM   1320 O O     . PRO   A 1 317  ? 114.305 132.656 168.108 1.00 65.26  ?  317  PRO   C O     1 
ATOM   1321 C CB    . PRO   A 1 317  ? 115.490 131.658 170.407 1.00 67.05  ?  317  PRO   C CB    1 
ATOM   1322 C CG    . PRO   A 1 317  ? 116.056 133.008 170.778 1.00 65.16  ?  317  PRO   C CG    1 
ATOM   1323 C CD    . PRO   A 1 317  ? 117.462 133.021 170.196 1.00 67.67  ?  317  PRO   C CD    1 
ATOM   1324 N N     . LEU   A 1 318  ? 115.533 131.433 166.671 1.00 65.59  ?  318  LEU   C N     1 
ATOM   1325 C CA    . LEU   A 1 318  ? 114.829 131.909 165.480 1.00 67.47  ?  318  LEU   C CA    1 
ATOM   1326 C C     . LEU   A 1 318  ? 113.352 131.536 165.502 1.00 68.91  ?  318  LEU   C C     1 
ATOM   1327 O O     . LEU   A 1 318  ? 112.522 132.251 164.946 1.00 67.42  ?  318  LEU   C O     1 
ATOM   1328 C CB    . LEU   A 1 318  ? 115.485 131.343 164.212 1.00 69.98  ?  318  LEU   C CB    1 
ATOM   1329 C CG    . LEU   A 1 318  ? 116.920 131.850 163.904 1.00 71.26  ?  318  LEU   C CG    1 
ATOM   1330 C CD1   . LEU   A 1 318  ? 117.494 131.051 162.742 1.00 56.05  ?  318  LEU   C CD1   1 
ATOM   1331 C CD2   . LEU   A 1 318  ? 116.880 133.343 163.560 1.00 66.75  ?  318  LEU   C CD2   1 
ATOM   1332 N N     . CYS   A 1 319  ? 113.018 130.426 166.151 1.00 69.52  ?  319  CYS   C N     1 
ATOM   1333 C CA    . CYS   A 1 319  ? 111.625 130.022 166.322 1.00 73.91  ?  319  CYS   C CA    1 
ATOM   1334 C C     . CYS   A 1 319  ? 110.849 129.889 165.017 1.00 71.52  ?  319  CYS   C C     1 
ATOM   1335 O O     . CYS   A 1 319  ? 110.018 130.732 164.683 1.00 67.82  ?  319  CYS   C O     1 
ATOM   1336 C CB    . CYS   A 1 319  ? 110.900 131.019 167.216 1.00 70.64  ?  319  CYS   C CB    1 
ATOM   1337 S SG    . CYS   A 1 319  ? 111.650 131.217 168.845 1.00 74.35  ?  319  CYS   C SG    1 
ATOM   1338 N N     . THR   A 1 320  ? 111.103 128.802 164.304 1.00 78.23  ?  320  THR   C N     1 
ATOM   1339 C CA    . THR   A 1 320  ? 110.366 128.475 163.094 1.00 71.37  ?  320  THR   C CA    1 
ATOM   1340 C C     . THR   A 1 320  ? 109.037 127.822 163.452 1.00 78.94  ?  320  THR   C C     1 
ATOM   1341 O O     . THR   A 1 320  ? 108.788 127.525 164.621 1.00 76.31  ?  320  THR   C O     1 
ATOM   1342 C CB    . THR   A 1 320  ? 111.191 127.543 162.192 1.00 72.89  ?  320  THR   C CB    1 
ATOM   1343 O OG1   . THR   A 1 320  ? 111.461 126.321 162.891 1.00 66.61  ?  320  THR   C OG1   1 
ATOM   1344 C CG2   . THR   A 1 320  ? 112.503 128.219 161.815 1.00 71.28  ?  320  THR   C CG2   1 
ATOM   1345 N N     . ASP   A 1 321  ? 108.189 127.620 162.444 1.00 77.60  ?  321  ASP   C N     1 
ATOM   1346 C CA    . ASP   A 1 321  ? 106.844 127.062 162.608 1.00 73.96  ?  321  ASP   C CA    1 
ATOM   1347 C C     . ASP   A 1 321  ? 105.835 128.165 162.874 1.00 78.06  ?  321  ASP   C C     1 
ATOM   1348 O O     . ASP   A 1 321  ? 105.864 128.829 163.913 1.00 76.42  ?  321  ASP   C O     1 
ATOM   1349 C CB    . ASP   A 1 321  ? 106.777 126.029 163.737 1.00 79.98  ?  321  ASP   C CB    1 
ATOM   1350 C CG    . ASP   A 1 321  ? 105.509 125.176 163.685 1.00 90.53  ?  321  ASP   C CG    1 
ATOM   1351 O OD1   . ASP   A 1 321  ? 104.584 125.544 162.972 1.00 74.57  ?  321  ASP   C OD1   1 
ATOM   1352 O OD2   . ASP   A 1 321  ? 105.472 124.164 164.353 1.00 83.09  -1 321  ASP   C OD2   1 
ATOM   1353 N N     . TRP   A 1 322  ? 104.947 128.373 161.910 1.00 74.63  ?  322  TRP   C N     1 
ATOM   1354 C CA    . TRP   A 1 322  ? 103.986 129.468 161.947 1.00 78.43  ?  322  TRP   C CA    1 
ATOM   1355 C C     . TRP   A 1 322  ? 102.975 129.316 163.075 1.00 80.92  ?  322  TRP   C C     1 
ATOM   1356 O O     . TRP   A 1 322  ? 102.277 130.270 163.430 1.00 70.95  ?  322  TRP   C O     1 
ATOM   1357 C CB    . TRP   A 1 322  ? 103.264 129.554 160.606 1.00 72.39  ?  322  TRP   C CB    1 
ATOM   1358 C CG    . TRP   A 1 322  ? 102.497 128.347 160.282 1.00 78.93  ?  322  TRP   C CG    1 
ATOM   1359 C CD1   . TRP   A 1 322  ? 102.954 127.249 159.633 1.00 75.04  ?  322  TRP   C CD1   1 
ATOM   1360 C CD2   . TRP   A 1 322  ? 101.109 128.096 160.576 1.00 78.88  ?  322  TRP   C CD2   1 
ATOM   1361 N NE1   . TRP   A 1 322  ? 101.956 126.326 159.512 1.00 77.02  ?  322  TRP   C NE1   1 
ATOM   1362 C CE2   . TRP   A 1 322  ? 100.814 126.831 160.078 1.00 76.78  ?  322  TRP   C CE2   1 
ATOM   1363 C CE3   . TRP   A 1 322  ? 100.109 128.836 161.205 1.00 78.89  ?  322  TRP   C CE3   1 
ATOM   1364 C CZ2   . TRP   A 1 322  ? 99.557  126.274 160.196 1.00 78.16  ?  322  TRP   C CZ2   1 
ATOM   1365 C CZ3   . TRP   A 1 322  ? 98.847  128.281 161.325 1.00 81.39  ?  322  TRP   C CZ3   1 
ATOM   1366 C CH2   . TRP   A 1 322  ? 98.577  127.031 160.830 1.00 80.10  ?  322  TRP   C CH2   1 
ATOM   1367 N N     . GLN   A 1 323  ? 102.882 128.110 163.629 1.00 93.46  ?  323  GLN   C N     1 
ATOM   1368 C CA    . GLN   A 1 323  ? 101.908 127.840 164.673 1.00 71.31  ?  323  GLN   C CA    1 
ATOM   1369 C C     . GLN   A 1 323  ? 102.360 128.346 166.038 1.00 75.01  ?  323  GLN   C C     1 
ATOM   1370 O O     . GLN   A 1 323  ? 101.551 128.454 166.961 1.00 77.65  ?  323  GLN   C O     1 
ATOM   1371 C CB    . GLN   A 1 323  ? 101.631 126.342 164.748 1.00 78.12  ?  323  GLN   C CB    1 
ATOM   1372 C CG    . GLN   A 1 323  ? 100.979 125.784 163.505 1.00 80.04  ?  323  GLN   C CG    1 
ATOM   1373 C CD    . GLN   A 1 323  ? 100.867 124.289 163.530 1.00 82.24  ?  323  GLN   C CD    1 
ATOM   1374 O OE1   . GLN   A 1 323  ? 99.825  123.720 163.873 1.00 86.74  ?  323  GLN   C OE1   1 
ATOM   1375 N NE2   . GLN   A 1 323  ? 101.960 123.629 163.166 1.00 72.55  ?  323  GLN   C NE2   1 
ATOM   1376 N N     . LYS   A 1 324  ? 103.647 128.641 166.180 1.00 72.23  ?  324  LYS   C N     1 
ATOM   1377 C CA    . LYS   A 1 324  ? 104.166 129.101 167.459 1.00 74.46  ?  324  LYS   C CA    1 
ATOM   1378 C C     . LYS   A 1 324  ? 104.121 130.619 167.566 1.00 74.42  ?  324  LYS   C C     1 
ATOM   1379 O O     . LYS   A 1 324  ? 104.621 131.321 166.688 1.00 75.60  ?  324  LYS   C O     1 
ATOM   1380 C CB    . LYS   A 1 324  ? 105.596 128.609 167.664 1.00 71.86  ?  324  LYS   C CB    1 
ATOM   1381 C CG    . LYS   A 1 324  ? 106.197 129.004 169.007 1.00 76.90  ?  324  LYS   C CG    1 
ATOM   1382 C CD    . LYS   A 1 324  ? 107.600 128.440 169.192 1.00 75.34  ?  324  LYS   C CD    1 
ATOM   1383 C CE    . LYS   A 1 324  ? 108.131 128.737 170.592 1.00 60.95  ?  324  LYS   C CE    1 
ATOM   1384 N NZ    . LYS   A 1 324  ? 108.389 130.194 170.798 1.00 63.74  1  324  LYS   C NZ    1 
ATOM   1385 N N     . ALA   A 1 325  ? 103.545 131.126 168.653 1.00 69.63  ?  325  ALA   C N     1 
ATOM   1386 C CA    . ALA   A 1 325  ? 103.515 132.564 168.871 1.00 69.74  ?  325  ALA   C CA    1 
ATOM   1387 C C     . ALA   A 1 325  ? 104.839 133.039 169.428 1.00 69.85  ?  325  ALA   C C     1 
ATOM   1388 O O     . ALA   A 1 325  ? 105.375 132.449 170.368 1.00 71.21  ?  325  ALA   C O     1 
ATOM   1389 C CB    . ALA   A 1 325  ? 102.381 132.952 169.806 1.00 67.82  ?  325  ALA   C CB    1 
ATOM   1390 N N     . GLU   A 1 326  ? 105.358 134.118 168.859 1.00 69.15  ?  326  GLU   C N     1 
ATOM   1391 C CA    . GLU   A 1 326  ? 106.628 134.665 169.306 1.00 66.98  ?  326  GLU   C CA    1 
ATOM   1392 C C     . GLU   A 1 326  ? 106.668 136.166 169.027 1.00 65.58  ?  326  GLU   C C     1 
ATOM   1393 O O     . GLU   A 1 326  ? 105.742 136.713 168.428 1.00 63.38  ?  326  GLU   C O     1 
ATOM   1394 C CB    . GLU   A 1 326  ? 107.764 133.908 168.605 1.00 68.24  ?  326  GLU   C CB    1 
ATOM   1395 C CG    . GLU   A 1 326  ? 109.155 134.214 169.091 1.00 69.26  ?  326  GLU   C CG    1 
ATOM   1396 C CD    . GLU   A 1 326  ? 109.288 134.131 170.576 1.00 72.44  ?  326  GLU   C CD    1 
ATOM   1397 O OE1   . GLU   A 1 326  ? 109.518 133.065 171.097 1.00 72.74  ?  326  GLU   C OE1   1 
ATOM   1398 O OE2   . GLU   A 1 326  ? 109.141 135.156 171.194 1.00 73.47  -1 326  GLU   C OE2   1 
ATOM   1399 N N     . ARG   A 1 327  ? 107.732 136.835 169.447 1.00 65.67  ?  327  ARG   C N     1 
ATOM   1400 C CA    . ARG   A 1 327  ? 107.860 138.267 169.205 1.00 62.17  ?  327  ARG   C CA    1 
ATOM   1401 C C     . ARG   A 1 327  ? 107.978 138.578 167.720 1.00 57.70  ?  327  ARG   C C     1 
ATOM   1402 O O     . ARG   A 1 327  ? 108.526 137.787 166.949 1.00 56.66  ?  327  ARG   C O     1 
ATOM   1403 C CB    . ARG   A 1 327  ? 109.053 138.843 169.940 1.00 60.75  ?  327  ARG   C CB    1 
ATOM   1404 C CG    . ARG   A 1 327  ? 108.876 138.973 171.439 1.00 63.96  ?  327  ARG   C CG    1 
ATOM   1405 C CD    . ARG   A 1 327  ? 110.055 139.613 172.071 1.00 68.50  ?  327  ARG   C CD    1 
ATOM   1406 N NE    . ARG   A 1 327  ? 110.281 140.959 171.553 1.00 69.00  ?  327  ARG   C NE    1 
ATOM   1407 C CZ    . ARG   A 1 327  ? 111.253 141.788 171.960 1.00 66.14  ?  327  ARG   C CZ    1 
ATOM   1408 N NH1   . ARG   A 1 327  ? 112.091 141.421 172.907 1.00 68.69  1  327  ARG   C NH1   1 
ATOM   1409 N NH2   . ARG   A 1 327  ? 111.357 142.972 171.394 1.00 60.47  ?  327  ARG   C NH2   1 
ATOM   1410 N N     . GLY   A 1 328  ? 107.455 139.736 167.329 1.00 53.53  ?  328  GLY   C N     1 
ATOM   1411 C CA    . GLY   A 1 328  ? 107.469 140.183 165.941 1.00 52.80  ?  328  GLY   C CA    1 
ATOM   1412 C C     . GLY   A 1 328  ? 108.867 140.256 165.329 1.00 50.17  ?  328  GLY   C C     1 
ATOM   1413 O O     . GLY   A 1 328  ? 109.030 140.013 164.135 1.00 48.93  ?  328  GLY   C O     1 
ATOM   1414 N N     . ASP   A 1 329  ? 109.881 140.585 166.122 1.00 49.66  ?  329  ASP   C N     1 
ATOM   1415 C CA    . ASP   A 1 329  ? 111.224 140.697 165.567 1.00 49.85  ?  329  ASP   C CA    1 
ATOM   1416 C C     . ASP   A 1 329  ? 111.760 139.329 165.193 1.00 52.02  ?  329  ASP   C C     1 
ATOM   1417 O O     . ASP   A 1 329  ? 112.345 139.146 164.123 1.00 48.38  ?  329  ASP   C O     1 
ATOM   1418 C CB    . ASP   A 1 329  ? 112.157 141.352 166.577 1.00 52.29  ?  329  ASP   C CB    1 
ATOM   1419 C CG    . ASP   A 1 329  ? 112.148 140.612 167.892 1.00 59.20  ?  329  ASP   C CG    1 
ATOM   1420 O OD1   . ASP   A 1 329  ? 111.166 139.948 168.158 1.00 59.35  ?  329  ASP   C OD1   1 
ATOM   1421 O OD2   . ASP   A 1 329  ? 113.109 140.695 168.615 1.00 65.22  -1 329  ASP   C OD2   1 
ATOM   1422 N N     . ILE   A 1 330  ? 111.517 138.363 166.061 1.00 54.62  ?  330  ILE   C N     1 
ATOM   1423 C CA    . ILE   A 1 330  ? 111.930 136.991 165.826 1.00 53.37  ?  330  ILE   C CA    1 
ATOM   1424 C C     . ILE   A 1 330  ? 111.151 136.420 164.651 1.00 49.42  ?  330  ILE   C C     1 
ATOM   1425 O O     . ILE   A 1 330  ? 111.713 135.742 163.789 1.00 49.41  ?  330  ILE   C O     1 
ATOM   1426 C CB    . ILE   A 1 330  ? 111.710 136.129 167.079 1.00 57.40  ?  330  ILE   C CB    1 
ATOM   1427 C CG1   . ILE   A 1 330  ? 112.642 136.603 168.217 1.00 60.85  ?  330  ILE   C CG1   1 
ATOM   1428 C CG2   . ILE   A 1 330  ? 111.976 134.661 166.750 1.00 61.85  ?  330  ILE   C CG2   1 
ATOM   1429 C CD1   . ILE   A 1 330  ? 112.313 136.028 169.576 1.00 66.15  ?  330  ILE   C CD1   1 
ATOM   1430 N N     . LEU   A 1 331  ? 109.851 136.695 164.621 1.00 47.84  ?  331  LEU   C N     1 
ATOM   1431 C CA    . LEU   A 1 331  ? 108.991 136.198 163.561 1.00 47.76  ?  331  LEU   C CA    1 
ATOM   1432 C C     . LEU   A 1 331  ? 109.419 136.746 162.202 1.00 48.65  ?  331  LEU   C C     1 
ATOM   1433 O O     . LEU   A 1 331  ? 109.520 135.996 161.228 1.00 47.64  ?  331  LEU   C O     1 
ATOM   1434 C CB    . LEU   A 1 331  ? 107.532 136.589 163.849 1.00 47.40  ?  331  LEU   C CB    1 
ATOM   1435 C CG    . LEU   A 1 331  ? 106.474 136.149 162.810 1.00 54.02  ?  331  LEU   C CG    1 
ATOM   1436 C CD1   . LEU   A 1 331  ? 106.432 134.628 162.731 1.00 55.99  ?  331  LEU   C CD1   1 
ATOM   1437 C CD2   . LEU   A 1 331  ? 105.112 136.706 163.216 1.00 57.82  ?  331  LEU   C CD2   1 
ATOM   1438 N N     . LEU   A 1 332  ? 109.695 138.049 162.139 1.00 47.98  ?  332  LEU   C N     1 
ATOM   1439 C CA    . LEU   A 1 332  ? 110.140 138.661 160.896 1.00 42.84  ?  332  LEU   C CA    1 
ATOM   1440 C C     . LEU   A 1 332  ? 111.507 138.146 160.486 1.00 42.76  ?  332  LEU   C C     1 
ATOM   1441 O O     . LEU   A 1 332  ? 111.757 137.926 159.302 1.00 41.98  ?  332  LEU   C O     1 
ATOM   1442 C CB    . LEU   A 1 332  ? 110.196 140.185 161.032 1.00 44.82  ?  332  LEU   C CB    1 
ATOM   1443 C CG    . LEU   A 1 332  ? 108.850 140.928 161.121 1.00 40.23  ?  332  LEU   C CG    1 
ATOM   1444 C CD1   . LEU   A 1 332  ? 109.130 142.379 161.463 1.00 42.35  ?  332  LEU   C CD1   1 
ATOM   1445 C CD2   . LEU   A 1 332  ? 108.099 140.818 159.793 1.00 35.57  ?  332  LEU   C CD2   1 
ATOM   1446 N N     . SER   A 1 333  ? 112.392 137.940 161.454 1.00 44.18  ?  333  SER   C N     1 
ATOM   1447 C CA    . SER   A 1 333  ? 113.723 137.441 161.148 1.00 44.36  ?  333  SER   C CA    1 
ATOM   1448 C C     . SER   A 1 333  ? 113.650 136.075 160.482 1.00 46.36  ?  333  SER   C C     1 
ATOM   1449 O O     . SER   A 1 333  ? 114.298 135.838 159.463 1.00 45.95  ?  333  SER   C O     1 
ATOM   1450 C CB    . SER   A 1 333  ? 114.547 137.359 162.415 1.00 47.57  ?  333  SER   C CB    1 
ATOM   1451 O OG    . SER   A 1 333  ? 115.820 136.834 162.159 1.00 49.84  ?  333  SER   C OG    1 
ATOM   1452 N N     . SER   A 1 334  ? 112.834 135.185 161.037 1.00 47.21  ?  334  SER   C N     1 
ATOM   1453 C CA    . SER   A 1 334  ? 112.681 133.844 160.492 1.00 46.76  ?  334  SER   C CA    1 
ATOM   1454 C C     . SER   A 1 334  ? 112.043 133.862 159.107 1.00 43.72  ?  334  SER   C C     1 
ATOM   1455 O O     . SER   A 1 334  ? 112.410 133.074 158.232 1.00 46.58  ?  334  SER   C O     1 
ATOM   1456 C CB    . SER   A 1 334  ? 111.865 133.003 161.445 1.00 56.21  ?  334  SER   C CB    1 
ATOM   1457 O OG    . SER   A 1 334  ? 112.570 132.794 162.636 1.00 62.42  ?  334  SER   C OG    1 
ATOM   1458 N N     . LEU   A 1 335  ? 111.105 134.778 158.886 1.00 44.38  ?  335  LEU   C N     1 
ATOM   1459 C CA    . LEU   A 1 335  ? 110.493 134.899 157.568 1.00 43.16  ?  335  LEU   C CA    1 
ATOM   1460 C C     . LEU   A 1 335  ? 111.509 135.422 156.548 1.00 42.47  ?  335  LEU   C C     1 
ATOM   1461 O O     . LEU   A 1 335  ? 111.643 134.874 155.454 1.00 43.28  ?  335  LEU   C O     1 
ATOM   1462 C CB    . LEU   A 1 335  ? 109.280 135.845 157.629 1.00 37.30  ?  335  LEU   C CB    1 
ATOM   1463 C CG    . LEU   A 1 335  ? 108.496 136.074 156.302 1.00 34.15  ?  335  LEU   C CG    1 
ATOM   1464 C CD1   . LEU   A 1 335  ? 107.902 134.751 155.802 1.00 44.50  ?  335  LEU   C CD1   1 
ATOM   1465 C CD2   . LEU   A 1 335  ? 107.391 137.102 156.547 1.00 32.49  ?  335  LEU   C CD2   1 
ATOM   1466 N N     . ILE   A 1 336  ? 112.248 136.466 156.919 1.00 41.97  ?  336  ILE   C N     1 
ATOM   1467 C CA    . ILE   A 1 336  ? 113.225 137.079 156.023 1.00 40.29  ?  336  ILE   C CA    1 
ATOM   1468 C C     . ILE   A 1 336  ? 114.362 136.118 155.714 1.00 42.05  ?  336  ILE   C C     1 
ATOM   1469 O O     . ILE   A 1 336  ? 114.838 136.052 154.581 1.00 44.07  ?  336  ILE   C O     1 
ATOM   1470 C CB    . ILE   A 1 336  ? 113.788 138.390 156.602 1.00 38.73  ?  336  ILE   C CB    1 
ATOM   1471 C CG1   . ILE   A 1 336  ? 112.670 139.445 156.693 1.00 37.47  ?  336  ILE   C CG1   1 
ATOM   1472 C CG2   . ILE   A 1 336  ? 114.913 138.911 155.694 1.00 37.65  ?  336  ILE   C CG2   1 
ATOM   1473 C CD1   . ILE   A 1 336  ? 113.029 140.636 157.554 1.00 39.24  ?  336  ILE   C CD1   1 
ATOM   1474 N N     . ARG   A 1 337  ? 114.796 135.370 156.724 1.00 43.62  ?  337  ARG   C N     1 
ATOM   1475 C CA    . ARG   A 1 337  ? 115.885 134.413 156.579 1.00 45.27  ?  337  ARG   C CA    1 
ATOM   1476 C C     . ARG   A 1 337  ? 115.452 133.123 155.884 1.00 46.97  ?  337  ARG   C C     1 
ATOM   1477 O O     . ARG   A 1 337  ? 116.266 132.219 155.698 1.00 48.79  ?  337  ARG   C O     1 
ATOM   1478 C CB    . ARG   A 1 337  ? 116.475 134.053 157.935 1.00 44.01  ?  337  ARG   C CB    1 
ATOM   1479 C CG    . ARG   A 1 337  ? 117.296 135.139 158.605 1.00 43.29  ?  337  ARG   C CG    1 
ATOM   1480 C CD    . ARG   A 1 337  ? 117.823 134.678 159.920 1.00 49.38  ?  337  ARG   C CD    1 
ATOM   1481 N NE    . ARG   A 1 337  ? 118.690 135.670 160.547 1.00 48.57  ?  337  ARG   C NE    1 
ATOM   1482 C CZ    . ARG   A 1 337  ? 119.986 135.861 160.216 1.00 46.87  ?  337  ARG   C CZ    1 
ATOM   1483 N NH1   . ARG   A 1 337  ? 120.532 135.129 159.268 1.00 46.08  1  337  ARG   C NH1   1 
ATOM   1484 N NH2   . ARG   A 1 337  ? 120.718 136.779 160.834 1.00 46.68  ?  337  ARG   C NH2   1 
ATOM   1485 N N     . LYS   A 1 338  ? 114.176 133.034 155.512 1.00 46.55  ?  338  LYS   C N     1 
ATOM   1486 C CA    . LYS   A 1 338  ? 113.627 131.859 154.846 1.00 48.71  ?  338  LYS   C CA    1 
ATOM   1487 C C     . LYS   A 1 338  ? 113.748 130.599 155.693 1.00 52.11  ?  338  LYS   C C     1 
ATOM   1488 O O     . LYS   A 1 338  ? 114.036 129.519 155.175 1.00 54.56  ?  338  LYS   C O     1 
ATOM   1489 C CB    . LYS   A 1 338  ? 114.315 131.632 153.498 1.00 51.66  ?  338  LYS   C CB    1 
ATOM   1490 C CG    . LYS   A 1 338  ? 114.190 132.789 152.526 1.00 50.28  ?  338  LYS   C CG    1 
ATOM   1491 C CD    . LYS   A 1 338  ? 114.774 132.435 151.166 1.00 54.89  ?  338  LYS   C CD    1 
ATOM   1492 C CE    . LYS   A 1 338  ? 116.298 132.413 151.199 1.00 58.51  ?  338  LYS   C CE    1 
ATOM   1493 N NZ    . LYS   A 1 338  ? 116.878 132.207 149.845 1.00 58.66  1  338  LYS   C NZ    1 
ATOM   1494 N N     . LYS   A 1 339  ? 113.506 130.732 156.992 1.00 52.63  ?  339  LYS   C N     1 
ATOM   1495 C CA    . LYS   A 1 339  ? 113.499 129.584 157.888 1.00 50.47  ?  339  LYS   C CA    1 
ATOM   1496 C C     . LYS   A 1 339  ? 112.053 129.230 158.180 1.00 53.84  ?  339  LYS   C C     1 
ATOM   1497 O O     . LYS   A 1 339  ? 111.693 128.065 158.353 1.00 59.40  ?  339  LYS   C O     1 
ATOM   1498 C CB    . LYS   A 1 339  ? 114.247 129.911 159.177 1.00 48.76  ?  339  LYS   C CB    1 
ATOM   1499 C CG    . LYS   A 1 339  ? 115.672 130.368 158.970 1.00 51.98  ?  339  LYS   C CG    1 
ATOM   1500 C CD    . LYS   A 1 339  ? 116.540 129.263 158.388 1.00 61.34  ?  339  LYS   C CD    1 
ATOM   1501 C CE    . LYS   A 1 339  ? 118.000 129.684 158.335 1.00 49.30  ?  339  LYS   C CE    1 
ATOM   1502 N NZ    . LYS   A 1 339  ? 118.858 128.650 157.692 1.00 46.82  1  339  LYS   C NZ    1 
ATOM   1503 N N     . LEU   A 1 340  ? 111.219 130.260 158.193 1.00 53.06  ?  340  LEU   C N     1 
ATOM   1504 C CA    . LEU   A 1 340  ? 109.789 130.114 158.377 1.00 51.98  ?  340  LEU   C CA    1 
ATOM   1505 C C     . LEU   A 1 340  ? 109.114 130.076 157.023 1.00 50.86  ?  340  LEU   C C     1 
ATOM   1506 O O     . LEU   A 1 340  ? 109.313 130.969 156.203 1.00 52.57  ?  340  LEU   C O     1 
ATOM   1507 C CB    . LEU   A 1 340  ? 109.233 131.281 159.196 1.00 52.44  ?  340  LEU   C CB    1 
ATOM   1508 C CG    . LEU   A 1 340  ? 107.710 131.345 159.331 1.00 54.34  ?  340  LEU   C CG    1 
ATOM   1509 C CD1   . LEU   A 1 340  ? 107.212 130.141 160.110 1.00 68.71  ?  340  LEU   C CD1   1 
ATOM   1510 C CD2   . LEU   A 1 340  ? 107.338 132.627 160.035 1.00 56.82  ?  340  LEU   C CD2   1 
ATOM   1511 N N     . LEU   A 1 341  ? 108.352 129.023 156.769 1.00 51.81  ?  341  LEU   C N     1 
ATOM   1512 C CA    . LEU   A 1 341  ? 107.703 128.867 155.479 1.00 50.92  ?  341  LEU   C CA    1 
ATOM   1513 C C     . LEU   A 1 341  ? 108.684 129.091 154.331 1.00 49.31  ?  341  LEU   C C     1 
ATOM   1514 O O     . LEU   A 1 341  ? 108.491 130.003 153.526 1.00 50.69  ?  341  LEU   C O     1 
ATOM   1515 C CB    . LEU   A 1 341  ? 106.544 129.864 155.353 1.00 49.85  ?  341  LEU   C CB    1 
ATOM   1516 C CG    . LEU   A 1 341  ? 105.423 129.747 156.394 1.00 56.56  ?  341  LEU   C CG    1 
ATOM   1517 C CD1   . LEU   A 1 341  ? 104.464 130.903 156.209 1.00 52.45  ?  341  LEU   C CD1   1 
ATOM   1518 C CD2   . LEU   A 1 341  ? 104.700 128.410 156.226 1.00 69.25  ?  341  LEU   C CD2   1 
ATOM   1519 N N     . PRO   A 1 342  ? 109.724 128.255 154.223 1.00 50.05  ?  342  PRO   C N     1 
ATOM   1520 C CA    . PRO   A 1 342  ? 110.788 128.331 153.246 1.00 49.64  ?  342  PRO   C CA    1 
ATOM   1521 C C     . PRO   A 1 342  ? 110.234 128.051 151.865 1.00 51.04  ?  342  PRO   C C     1 
ATOM   1522 O O     . PRO   A 1 342  ? 109.175 127.444 151.732 1.00 53.00  ?  342  PRO   C O     1 
ATOM   1523 C CB    . PRO   A 1 342  ? 111.750 127.233 153.709 1.00 56.22  ?  342  PRO   C CB    1 
ATOM   1524 C CG    . PRO   A 1 342  ? 110.879 126.261 154.468 1.00 62.15  ?  342  PRO   C CG    1 
ATOM   1525 C CD    . PRO   A 1 342  ? 109.852 127.127 155.159 1.00 56.63  ?  342  PRO   C CD    1 
ATOM   1526 N N     . GLU   A 1 343  ? 110.954 128.495 150.843 1.00 52.41  ?  343  GLU   C N     1 
ATOM   1527 C CA    . GLU   A 1 343  ? 110.556 128.324 149.446 1.00 54.82  ?  343  GLU   C CA    1 
ATOM   1528 C C     . GLU   A 1 343  ? 109.372 129.221 149.097 1.00 51.98  ?  343  GLU   C C     1 
ATOM   1529 O O     . GLU   A 1 343  ? 108.771 129.094 148.031 1.00 54.56  ?  343  GLU   C O     1 
ATOM   1530 C CB    . GLU   A 1 343  ? 110.216 126.859 149.137 1.00 62.77  ?  343  GLU   C CB    1 
ATOM   1531 C CG    . GLU   A 1 343  ? 111.302 125.862 149.517 1.00 64.01  ?  343  GLU   C CG    1 
ATOM   1532 C CD    . GLU   A 1 343  ? 112.558 126.044 148.726 1.00 65.79  ?  343  GLU   C CD    1 
ATOM   1533 O OE1   . GLU   A 1 343  ? 112.466 126.258 147.542 1.00 60.88  ?  343  GLU   C OE1   1 
ATOM   1534 O OE2   . GLU   A 1 343  ? 113.615 125.978 149.306 1.00 63.63  -1 343  GLU   C OE2   1 
ATOM   1535 N N     . ALA   A 1 344  ? 109.060 130.156 149.981 1.00 50.56  ?  344  ALA   C N     1 
ATOM   1536 C CA    . ALA   A 1 344  ? 108.075 131.184 149.694 1.00 47.35  ?  344  ALA   C CA    1 
ATOM   1537 C C     . ALA   A 1 344  ? 108.808 132.392 149.142 1.00 45.29  ?  344  ALA   C C     1 
ATOM   1538 O O     . ALA   A 1 344  ? 110.006 132.552 149.385 1.00 44.99  ?  344  ALA   C O     1 
ATOM   1539 C CB    . ALA   A 1 344  ? 107.280 131.541 150.938 1.00 45.37  ?  344  ALA   C CB    1 
ATOM   1540 N N     . SER   A 1 345  ? 108.111 133.235 148.398 1.00 42.26  ?  345  SER   C N     1 
ATOM   1541 C CA    . SER   A 1 345  ? 108.743 134.433 147.874 1.00 37.62  ?  345  SER   C CA    1 
ATOM   1542 C C     . SER   A 1 345  ? 108.526 135.593 148.830 1.00 35.49  ?  345  SER   C C     1 
ATOM   1543 O O     . SER   A 1 345  ? 107.510 135.655 149.526 1.00 36.72  ?  345  SER   C O     1 
ATOM   1544 C CB    . SER   A 1 345  ? 108.204 134.765 146.500 1.00 37.09  ?  345  SER   C CB    1 
ATOM   1545 O OG    . SER   A 1 345  ? 108.517 133.760 145.576 1.00 42.97  ?  345  SER   C OG    1 
ATOM   1546 N N     . LEU   A 1 346  ? 109.487 136.504 148.868 1.00 33.26  ?  346  LEU   C N     1 
ATOM   1547 C CA    . LEU   A 1 346  ? 109.399 137.671 149.729 1.00 29.16  ?  346  LEU   C CA    1 
ATOM   1548 C C     . LEU   A 1 346  ? 109.955 138.914 149.056 1.00 24.85  ?  346  LEU   C C     1 
ATOM   1549 O O     . LEU   A 1 346  ? 111.088 138.924 148.578 1.00 27.69  ?  346  LEU   C O     1 
ATOM   1550 C CB    . LEU   A 1 346  ? 110.153 137.402 151.036 1.00 30.15  ?  346  LEU   C CB    1 
ATOM   1551 C CG    . LEU   A 1 346  ? 110.265 138.575 152.021 1.00 30.95  ?  346  LEU   C CG    1 
ATOM   1552 C CD1   . LEU   A 1 346  ? 108.891 138.973 152.541 1.00 29.94  ?  346  LEU   C CD1   1 
ATOM   1553 C CD2   . LEU   A 1 346  ? 111.154 138.157 153.165 1.00 36.65  ?  346  LEU   C CD2   1 
ATOM   1554 N N     . LEU   A 1 347  ? 109.157 139.967 149.041 1.00 24.00  ?  347  LEU   C N     1 
ATOM   1555 C CA    . LEU   A 1 347  ? 109.567 141.243 148.487 1.00 22.27  ?  347  LEU   C CA    1 
ATOM   1556 C C     . LEU   A 1 347  ? 109.638 142.259 149.609 1.00 22.21  ?  347  LEU   C C     1 
ATOM   1557 O O     . LEU   A 1 347  ? 108.677 142.433 150.354 1.00 23.07  ?  347  LEU   C O     1 
ATOM   1558 C CB    . LEU   A 1 347  ? 108.573 141.683 147.414 1.00 21.68  ?  347  LEU   C CB    1 
ATOM   1559 C CG    . LEU   A 1 347  ? 108.939 142.877 146.555 1.00 21.36  ?  347  LEU   C CG    1 
ATOM   1560 C CD1   . LEU   A 1 347  ? 108.292 142.673 145.196 1.00 29.08  ?  347  LEU   C CD1   1 
ATOM   1561 C CD2   . LEU   A 1 347  ? 108.442 144.171 147.206 1.00 21.71  ?  347  LEU   C CD2   1 
ATOM   1562 N N     . ILE   A 1 348  ? 110.781 142.908 149.757 1.00 20.12  ?  348  ILE   C N     1 
ATOM   1563 C CA    . ILE   A 1 348  ? 110.965 143.858 150.847 1.00 16.95  ?  348  ILE   C CA    1 
ATOM   1564 C C     . ILE   A 1 348  ? 111.222 145.255 150.325 1.00 17.54  ?  348  ILE   C C     1 
ATOM   1565 O O     . ILE   A 1 348  ? 112.092 145.447 149.483 1.00 19.09  ?  348  ILE   C O     1 
ATOM   1566 C CB    . ILE   A 1 348  ? 112.150 143.445 151.737 1.00 16.67  ?  348  ILE   C CB    1 
ATOM   1567 C CG1   . ILE   A 1 348  ? 111.917 142.046 152.293 1.00 21.53  ?  348  ILE   C CG1   1 
ATOM   1568 C CG2   . ILE   A 1 348  ? 112.327 144.458 152.871 1.00 19.93  ?  348  ILE   C CG2   1 
ATOM   1569 C CD1   . ILE   A 1 348  ? 113.133 141.433 152.926 1.00 26.95  ?  348  ILE   C CD1   1 
ATOM   1570 N N     . THR   A 1 349  ? 110.495 146.236 150.846 1.00 18.15  ?  349  THR   C N     1 
ATOM   1571 C CA    . THR   A 1 349  ? 110.773 147.622 150.487 1.00 13.76  ?  349  THR   C CA    1 
ATOM   1572 C C     . THR   A 1 349  ? 111.454 148.292 151.670 1.00 16.87  ?  349  THR   C C     1 
ATOM   1573 O O     . THR   A 1 349  ? 111.024 148.131 152.816 1.00 20.15  ?  349  THR   C O     1 
ATOM   1574 C CB    . THR   A 1 349  ? 109.500 148.404 150.138 1.00 14.41  ?  349  THR   C CB    1 
ATOM   1575 O OG1   . THR   A 1 349  ? 108.697 148.522 151.308 1.00 21.22  ?  349  THR   C OG1   1 
ATOM   1576 C CG2   . THR   A 1 349  ? 108.712 147.686 149.055 1.00 17.01  ?  349  THR   C CG2   1 
ATOM   1577 N N     . THR   A 1 350  ? 112.510 149.053 151.402 1.00 16.73  ?  350  THR   C N     1 
ATOM   1578 C CA    . THR   A 1 350  ? 113.239 149.693 152.491 1.00 14.91  ?  350  THR   C CA    1 
ATOM   1579 C C     . THR   A 1 350  ? 114.022 150.923 152.059 1.00 13.58  ?  350  THR   C C     1 
ATOM   1580 O O     . THR   A 1 350  ? 114.459 151.028 150.916 1.00 14.02  ?  350  THR   C O     1 
ATOM   1581 C CB    . THR   A 1 350  ? 114.207 148.680 153.131 1.00 16.72  ?  350  THR   C CB    1 
ATOM   1582 O OG1   . THR   A 1 350  ? 114.781 149.240 154.307 1.00 18.44  ?  350  THR   C OG1   1 
ATOM   1583 C CG2   . THR   A 1 350  ? 115.314 148.309 152.165 1.00 17.58  ?  350  THR   C CG2   1 
ATOM   1584 N N     . ARG   A 1 351  ? 114.260 151.825 152.996 1.00 14.86  ?  351  ARG   C N     1 
ATOM   1585 C CA    . ARG   A 1 351  ? 115.198 152.912 152.751 1.00 11.92  ?  351  ARG   C CA    1 
ATOM   1586 C C     . ARG   A 1 351  ? 116.617 152.338 152.770 1.00 14.22  ?  351  ARG   C C     1 
ATOM   1587 O O     . ARG   A 1 351  ? 116.921 151.527 153.640 1.00 16.90  ?  351  ARG   C O     1 
ATOM   1588 C CB    . ARG   A 1 351  ? 115.070 154.000 153.800 1.00 11.70  ?  351  ARG   C CB    1 
ATOM   1589 C CG    . ARG   A 1 351  ? 113.781 154.773 153.755 1.00 10.37  ?  351  ARG   C CG    1 
ATOM   1590 C CD    . ARG   A 1 351  ? 113.685 155.718 154.881 1.00 13.33  ?  351  ARG   C CD    1 
ATOM   1591 N NE    . ARG   A 1 351  ? 114.627 156.799 154.738 1.00 15.70  ?  351  ARG   C NE    1 
ATOM   1592 C CZ    . ARG   A 1 351  ? 115.021 157.615 155.727 1.00 17.55  ?  351  ARG   C CZ    1 
ATOM   1593 N NH1   . ARG   A 1 351  ? 114.549 157.466 156.944 1.00 16.32  1  351  ARG   C NH1   1 
ATOM   1594 N NH2   . ARG   A 1 351  ? 115.887 158.573 155.468 1.00 19.82  ?  351  ARG   C NH2   1 
ATOM   1595 N N     . PRO   A 1 352  ? 117.509 152.753 151.860 1.00 14.62  ?  352  PRO   C N     1 
ATOM   1596 C CA    . PRO   A 1 352  ? 118.877 152.283 151.728 1.00 13.28  ?  352  PRO   C CA    1 
ATOM   1597 C C     . PRO   A 1 352  ? 119.636 152.280 153.047 1.00 15.97  ?  352  PRO   C C     1 
ATOM   1598 O O     . PRO   A 1 352  ? 120.467 151.408 153.291 1.00 18.90  ?  352  PRO   C O     1 
ATOM   1599 C CB    . PRO   A 1 352  ? 119.470 153.306 150.760 1.00 13.74  ?  352  PRO   C CB    1 
ATOM   1600 C CG    . PRO   A 1 352  ? 118.309 153.737 149.921 1.00 10.65  ?  352  PRO   C CG    1 
ATOM   1601 C CD    . PRO   A 1 352  ? 117.131 153.761 150.870 1.00 12.52  ?  352  PRO   C CD    1 
ATOM   1602 N N     . VAL   A 1 353  ? 119.340 153.237 153.912 1.00 15.65  ?  353  VAL   C N     1 
ATOM   1603 C CA    . VAL   A 1 353  ? 120.028 153.333 155.188 1.00 14.76  ?  353  VAL   C CA    1 
ATOM   1604 C C     . VAL   A 1 353  ? 119.801 152.110 156.067 1.00 18.04  ?  353  VAL   C C     1 
ATOM   1605 O O     . VAL   A 1 353  ? 120.670 151.729 156.852 1.00 21.27  ?  353  VAL   C O     1 
ATOM   1606 C CB    . VAL   A 1 353  ? 119.587 154.611 155.930 1.00 14.17  ?  353  VAL   C CB    1 
ATOM   1607 C CG1   . VAL   A 1 353  ? 118.139 154.505 156.394 1.00 15.32  ?  353  VAL   C CG1   1 
ATOM   1608 C CG2   . VAL   A 1 353  ? 120.501 154.837 157.112 1.00 21.15  ?  353  VAL   C CG2   1 
ATOM   1609 N N     . ALA   A 1 354  ? 118.637 151.489 155.943 1.00 19.16  ?  354  ALA   C N     1 
ATOM   1610 C CA    . ALA   A 1 354  ? 118.279 150.378 156.807 1.00 18.50  ?  354  ALA   C CA    1 
ATOM   1611 C C     . ALA   A 1 354  ? 118.851 149.071 156.300 1.00 19.50  ?  354  ALA   C C     1 
ATOM   1612 O O     . ALA   A 1 354  ? 118.707 148.032 156.952 1.00 25.27  ?  354  ALA   C O     1 
ATOM   1613 C CB    . ALA   A 1 354  ? 116.778 150.280 156.930 1.00 19.22  ?  354  ALA   C CB    1 
ATOM   1614 N N     . LEU   A 1 355  ? 119.541 149.119 155.166 1.00 18.26  ?  355  LEU   C N     1 
ATOM   1615 C CA    . LEU   A 1 355  ? 120.159 147.923 154.626 1.00 19.66  ?  355  LEU   C CA    1 
ATOM   1616 C C     . LEU   A 1 355  ? 121.306 147.504 155.521 1.00 24.53  ?  355  LEU   C C     1 
ATOM   1617 O O     . LEU   A 1 355  ? 121.758 146.362 155.475 1.00 28.15  ?  355  LEU   C O     1 
ATOM   1618 C CB    . LEU   A 1 355  ? 120.661 148.162 153.200 1.00 21.02  ?  355  LEU   C CB    1 
ATOM   1619 C CG    . LEU   A 1 355  ? 119.580 148.387 152.131 1.00 20.26  ?  355  LEU   C CG    1 
ATOM   1620 C CD1   . LEU   A 1 355  ? 120.240 148.813 150.843 1.00 20.38  ?  355  LEU   C CD1   1 
ATOM   1621 C CD2   . LEU   A 1 355  ? 118.792 147.107 151.916 1.00 20.49  ?  355  LEU   C CD2   1 
ATOM   1622 N N     . GLU   A 1 356  ? 121.746 148.419 156.380 1.00 26.35  ?  356  GLU   C N     1 
ATOM   1623 C CA    . GLU   A 1 356  ? 122.807 148.122 157.321 1.00 29.71  ?  356  GLU   C CA    1 
ATOM   1624 C C     . GLU   A 1 356  ? 122.428 146.922 158.187 1.00 33.08  ?  356  GLU   C C     1 
ATOM   1625 O O     . GLU   A 1 356  ? 123.278 146.093 158.505 1.00 39.22  ?  356  GLU   C O     1 
ATOM   1626 C CB    . GLU   A 1 356  ? 123.109 149.355 158.178 1.00 29.54  ?  356  GLU   C CB    1 
ATOM   1627 C CG    . GLU   A 1 356  ? 124.395 149.274 159.008 1.00 44.54  ?  356  GLU   C CG    1 
ATOM   1628 C CD    . GLU   A 1 356  ? 124.190 148.772 160.414 1.00 50.17  ?  356  GLU   C CD    1 
ATOM   1629 O OE1   . GLU   A 1 356  ? 123.183 149.093 160.998 1.00 40.49  ?  356  GLU   C OE1   1 
ATOM   1630 O OE2   . GLU   A 1 356  ? 125.046 148.076 160.909 1.00 48.38  -1 356  GLU   C OE2   1 
ATOM   1631 N N     . LYS   A 1 357  ? 121.144 146.798 158.535 1.00 29.55  ?  357  LYS   C N     1 
ATOM   1632 C CA    . LYS   A 1 357  ? 120.705 145.648 159.316 1.00 29.89  ?  357  LYS   C CA    1 
ATOM   1633 C C     . LYS   A 1 357  ? 120.137 144.552 158.431 1.00 30.25  ?  357  LYS   C C     1 
ATOM   1634 O O     . LYS   A 1 357  ? 120.374 143.367 158.665 1.00 35.81  ?  357  LYS   C O     1 
ATOM   1635 C CB    . LYS   A 1 357  ? 119.657 146.049 160.351 1.00 29.28  ?  357  LYS   C CB    1 
ATOM   1636 C CG    . LYS   A 1 357  ? 120.199 146.858 161.487 1.00 35.85  ?  357  LYS   C CG    1 
ATOM   1637 C CD    . LYS   A 1 357  ? 119.141 147.092 162.551 1.00 33.73  ?  357  LYS   C CD    1 
ATOM   1638 C CE    . LYS   A 1 357  ? 119.713 147.858 163.730 1.00 38.16  ?  357  LYS   C CE    1 
ATOM   1639 N NZ    . LYS   A 1 357  ? 120.687 147.044 164.509 1.00 45.54  1  357  LYS   C NZ    1 
ATOM   1640 N N     . LEU   A 1 358  ? 119.391 144.942 157.406 1.00 26.88  ?  358  LEU   C N     1 
ATOM   1641 C CA    . LEU   A 1 358  ? 118.710 143.965 156.571 1.00 29.01  ?  358  LEU   C CA    1 
ATOM   1642 C C     . LEU   A 1 358  ? 119.697 143.037 155.867 1.00 31.68  ?  358  LEU   C C     1 
ATOM   1643 O O     . LEU   A 1 358  ? 119.407 141.861 155.645 1.00 35.94  ?  358  LEU   C O     1 
ATOM   1644 C CB    . LEU   A 1 358  ? 117.816 144.676 155.545 1.00 25.92  ?  358  LEU   C CB    1 
ATOM   1645 C CG    . LEU   A 1 358  ? 116.892 143.781 154.701 1.00 27.78  ?  358  LEU   C CG    1 
ATOM   1646 C CD1   . LEU   A 1 358  ? 115.955 142.994 155.589 1.00 30.71  ?  358  LEU   C CD1   1 
ATOM   1647 C CD2   . LEU   A 1 358  ? 116.102 144.644 153.733 1.00 25.54  ?  358  LEU   C CD2   1 
ATOM   1648 N N     . GLN   A 1 359  ? 120.876 143.549 155.536 1.00 32.27  ?  359  GLN   C N     1 
ATOM   1649 C CA    . GLN   A 1 359  ? 121.877 142.765 154.820 1.00 36.15  ?  359  GLN   C CA    1 
ATOM   1650 C C     . GLN   A 1 359  ? 122.252 141.473 155.537 1.00 38.96  ?  359  GLN   C C     1 
ATOM   1651 O O     . GLN   A 1 359  ? 122.760 140.542 154.912 1.00 42.87  ?  359  GLN   C O     1 
ATOM   1652 C CB    . GLN   A 1 359  ? 123.149 143.591 154.611 1.00 39.39  ?  359  GLN   C CB    1 
ATOM   1653 C CG    . GLN   A 1 359  ? 123.933 143.860 155.892 1.00 38.94  ?  359  GLN   C CG    1 
ATOM   1654 C CD    . GLN   A 1 359  ? 125.119 144.775 155.673 1.00 46.62  ?  359  GLN   C CD    1 
ATOM   1655 O OE1   . GLN   A 1 359  ? 125.862 144.622 154.697 1.00 51.25  ?  359  GLN   C OE1   1 
ATOM   1656 N NE2   . GLN   A 1 359  ? 125.309 145.726 156.578 1.00 43.47  ?  359  GLN   C NE2   1 
ATOM   1657 N N     . HIS   A 1 360  ? 122.018 141.412 156.845 1.00 40.79  ?  360  HIS   C N     1 
ATOM   1658 C CA    . HIS   A 1 360  ? 122.400 140.244 157.626 1.00 41.38  ?  360  HIS   C CA    1 
ATOM   1659 C C     . HIS   A 1 360  ? 121.309 139.186 157.626 1.00 39.60  ?  360  HIS   C C     1 
ATOM   1660 O O     . HIS   A 1 360  ? 121.529 138.055 158.056 1.00 43.34  ?  360  HIS   C O     1 
ATOM   1661 C CB    . HIS   A 1 360  ? 122.716 140.655 159.061 1.00 43.92  ?  360  HIS   C CB    1 
ATOM   1662 C CG    . HIS   A 1 360  ? 123.905 141.545 159.164 1.00 46.47  ?  360  HIS   C CG    1 
ATOM   1663 N ND1   . HIS   A 1 360  ? 125.189 141.097 158.944 1.00 47.75  ?  360  HIS   C ND1   1 
ATOM   1664 C CD2   . HIS   A 1 360  ? 124.009 142.860 159.450 1.00 43.88  ?  360  HIS   C CD2   1 
ATOM   1665 C CE1   . HIS   A 1 360  ? 126.032 142.102 159.094 1.00 54.31  ?  360  HIS   C CE1   1 
ATOM   1666 N NE2   . HIS   A 1 360  ? 125.341 143.181 159.401 1.00 50.13  ?  360  HIS   C NE2   1 
ATOM   1667 N N     . LEU   A 1 361  ? 120.129 139.559 157.152 1.00 39.33  ?  361  LEU   C N     1 
ATOM   1668 C CA    . LEU   A 1 361  ? 118.996 138.652 157.136 1.00 38.71  ?  361  LEU   C CA    1 
ATOM   1669 C C     . LEU   A 1 361  ? 118.784 138.063 155.749 1.00 40.99  ?  361  LEU   C C     1 
ATOM   1670 O O     . LEU   A 1 361  ? 118.259 136.961 155.605 1.00 46.21  ?  361  LEU   C O     1 
ATOM   1671 C CB    . LEU   A 1 361  ? 117.727 139.400 157.555 1.00 35.67  ?  361  LEU   C CB    1 
ATOM   1672 C CG    . LEU   A 1 361  ? 117.759 140.109 158.916 1.00 37.20  ?  361  LEU   C CG    1 
ATOM   1673 C CD1   . LEU   A 1 361  ? 116.449 140.848 159.121 1.00 35.93  ?  361  LEU   C CD1   1 
ATOM   1674 C CD2   . LEU   A 1 361  ? 117.974 139.100 160.014 1.00 46.08  ?  361  LEU   C CD2   1 
ATOM   1675 N N     . LEU   A 1 362  ? 119.162 138.825 154.731 1.00 39.39  ?  362  LEU   C N     1 
ATOM   1676 C CA    . LEU   A 1 362  ? 118.877 138.472 153.345 1.00 42.63  ?  362  LEU   C CA    1 
ATOM   1677 C C     . LEU   A 1 362  ? 119.738 137.345 152.781 1.00 45.77  ?  362  LEU   C C     1 
ATOM   1678 O O     . LEU   A 1 362  ? 119.264 136.540 151.974 1.00 42.90  ?  362  LEU   C O     1 
ATOM   1679 C CB    . LEU   A 1 362  ? 119.092 139.705 152.473 1.00 40.29  ?  362  LEU   C CB    1 
ATOM   1680 C CG    . LEU   A 1 362  ? 118.185 140.892 152.744 1.00 34.64  ?  362  LEU   C CG    1 
ATOM   1681 C CD1   . LEU   A 1 362  ? 118.718 142.104 151.976 1.00 34.84  ?  362  LEU   C CD1   1 
ATOM   1682 C CD2   . LEU   A 1 362  ? 116.772 140.578 152.326 1.00 35.15  ?  362  LEU   C CD2   1 
ATOM   1683 N N     . ASP   A 1 363  ? 121.013 137.322 153.158 1.00 47.13  ?  363  ASP   C N     1 
ATOM   1684 C CA    . ASP   A 1 363  ? 121.988 136.356 152.639 1.00 54.70  ?  363  ASP   C CA    1 
ATOM   1685 C C     . ASP   A 1 363  ? 122.245 136.491 151.133 1.00 51.90  ?  363  ASP   C C     1 
ATOM   1686 O O     . ASP   A 1 363  ? 123.326 136.915 150.725 1.00 53.41  ?  363  ASP   C O     1 
ATOM   1687 C CB    . ASP   A 1 363  ? 121.573 134.916 152.968 1.00 59.43  ?  363  ASP   C CB    1 
ATOM   1688 C CG    . ASP   A 1 363  ? 121.763 134.562 154.437 1.00 62.63  ?  363  ASP   C CG    1 
ATOM   1689 O OD1   . ASP   A 1 363  ? 122.467 135.273 155.119 1.00 57.39  ?  363  ASP   C OD1   1 
ATOM   1690 O OD2   . ASP   A 1 363  ? 121.213 133.577 154.861 1.00 57.45  -1 363  ASP   C OD2   1 
ATOM   1691 N N     . HIS   A 1 364  ? 121.264 136.121 150.308 1.00 47.37  ?  364  HIS   C N     1 
ATOM   1692 C CA    . HIS   A 1 364  ? 121.443 136.163 148.854 1.00 45.00  ?  364  HIS   C CA    1 
ATOM   1693 C C     . HIS   A 1 364  ? 120.235 136.738 148.103 1.00 45.42  ?  364  HIS   C C     1 
ATOM   1694 O O     . HIS   A 1 364  ? 119.567 136.011 147.367 1.00 43.17  ?  364  HIS   C O     1 
ATOM   1695 C CB    . HIS   A 1 364  ? 121.732 134.760 148.321 1.00 48.79  ?  364  HIS   C CB    1 
ATOM   1696 C CG    . HIS   A 1 364  ? 122.944 134.124 148.931 1.00 60.83  ?  364  HIS   C CG    1 
ATOM   1697 N ND1   . HIS   A 1 364  ? 124.230 134.483 148.584 1.00 62.44  ?  364  HIS   C ND1   1 
ATOM   1698 C CD2   . HIS   A 1 364  ? 123.064 133.153 149.866 1.00 64.99  ?  364  HIS   C CD2   1 
ATOM   1699 C CE1   . HIS   A 1 364  ? 125.088 133.762 149.282 1.00 57.83  ?  364  HIS   C CE1   1 
ATOM   1700 N NE2   . HIS   A 1 364  ? 124.406 132.947 150.067 1.00 54.80  ?  364  HIS   C NE2   1 
ATOM   1701 N N     . PRO   A 1 365  ? 119.932 138.028 148.293 1.00 40.83  ?  365  PRO   C N     1 
ATOM   1702 C CA    . PRO   A 1 365  ? 118.835 138.784 147.708 1.00 32.51  ?  365  PRO   C CA    1 
ATOM   1703 C C     . PRO   A 1 365  ? 119.105 139.250 146.286 1.00 31.98  ?  365  PRO   C C     1 
ATOM   1704 O O     . PRO   A 1 365  ? 120.257 139.423 145.887 1.00 33.57  ?  365  PRO   C O     1 
ATOM   1705 C CB    . PRO   A 1 365  ? 118.768 139.990 148.628 1.00 30.94  ?  365  PRO   C CB    1 
ATOM   1706 C CG    . PRO   A 1 365  ? 120.211 140.200 149.029 1.00 37.48  ?  365  PRO   C CG    1 
ATOM   1707 C CD    . PRO   A 1 365  ? 120.777 138.820 149.184 1.00 40.11  ?  365  PRO   C CD    1 
ATOM   1708 N N     . ARG   A 1 366  ? 118.032 139.580 145.577 1.00 29.55  ?  366  ARG   C N     1 
ATOM   1709 C CA    . ARG   A 1 366  ? 118.118 140.373 144.358 1.00 25.91  ?  366  ARG   C CA    1 
ATOM   1710 C C     . ARG   A 1 366  ? 117.766 141.814 144.696 1.00 25.67  ?  366  ARG   C C     1 
ATOM   1711 O O     . ARG   A 1 366  ? 116.782 142.062 145.389 1.00 26.40  ?  366  ARG   C O     1 
ATOM   1712 C CB    . ARG   A 1 366  ? 117.166 139.847 143.301 1.00 26.64  ?  366  ARG   C CB    1 
ATOM   1713 C CG    . ARG   A 1 366  ? 117.105 140.669 142.022 1.00 28.77  ?  366  ARG   C CG    1 
ATOM   1714 C CD    . ARG   A 1 366  ? 116.263 140.019 140.986 1.00 33.96  ?  366  ARG   C CD    1 
ATOM   1715 N NE    . ARG   A 1 366  ? 116.880 138.804 140.479 1.00 48.77  ?  366  ARG   C NE    1 
ATOM   1716 C CZ    . ARG   A 1 366  ? 116.283 137.908 139.663 1.00 52.07  ?  366  ARG   C CZ    1 
ATOM   1717 N NH1   . ARG   A 1 366  ? 115.050 138.081 139.240 1.00 48.49  1  366  ARG   C NH1   1 
ATOM   1718 N NH2   . ARG   A 1 366  ? 116.938 136.830 139.280 1.00 63.06  ?  366  ARG   C NH2   1 
ATOM   1719 N N     . HIS   A 1 367  ? 118.562 142.766 144.231 1.00 24.10  ?  367  HIS   C N     1 
ATOM   1720 C CA    . HIS   A 1 367  ? 118.302 144.161 144.573 1.00 18.18  ?  367  HIS   C CA    1 
ATOM   1721 C C     . HIS   A 1 367  ? 117.817 145.008 143.409 1.00 20.79  ?  367  HIS   C C     1 
ATOM   1722 O O     . HIS   A 1 367  ? 118.373 144.964 142.310 1.00 26.14  ?  367  HIS   C O     1 
ATOM   1723 C CB    . HIS   A 1 367  ? 119.551 144.811 145.160 1.00 20.32  ?  367  HIS   C CB    1 
ATOM   1724 C CG    . HIS   A 1 367  ? 119.865 144.371 146.540 1.00 20.71  ?  367  HIS   C CG    1 
ATOM   1725 N ND1   . HIS   A 1 367  ? 119.354 145.006 147.647 1.00 21.38  ?  367  HIS   C ND1   1 
ATOM   1726 C CD2   . HIS   A 1 367  ? 120.636 143.368 147.004 1.00 22.61  ?  367  HIS   C CD2   1 
ATOM   1727 C CE1   . HIS   A 1 367  ? 119.799 144.413 148.735 1.00 21.77  ?  367  HIS   C CE1   1 
ATOM   1728 N NE2   . HIS   A 1 367  ? 120.581 143.419 148.375 1.00 22.05  ?  367  HIS   C NE2   1 
ATOM   1729 N N     . VAL   A 1 368  ? 116.798 145.812 143.687 1.00 18.05  ?  368  VAL   C N     1 
ATOM   1730 C CA    . VAL   A 1 368  ? 116.262 146.780 142.745 1.00 17.17  ?  368  VAL   C CA    1 
ATOM   1731 C C     . VAL   A 1 368  ? 116.196 148.159 143.387 1.00 16.40  ?  368  VAL   C C     1 
ATOM   1732 O O     . VAL   A 1 368  ? 115.696 148.305 144.500 1.00 17.73  ?  368  VAL   C O     1 
ATOM   1733 C CB    . VAL   A 1 368  ? 114.853 146.367 142.288 1.00 18.19  ?  368  VAL   C CB    1 
ATOM   1734 C CG1   . VAL   A 1 368  ? 114.289 147.406 141.321 1.00 20.48  ?  368  VAL   C CG1   1 
ATOM   1735 C CG2   . VAL   A 1 368  ? 114.915 144.999 141.629 1.00 22.21  ?  368  VAL   C CG2   1 
ATOM   1736 N N     . GLU   A 1 369  ? 116.694 149.171 142.694 1.00 18.39  ?  369  GLU   C N     1 
ATOM   1737 C CA    . GLU   A 1 369  ? 116.604 150.530 143.204 1.00 15.08  ?  369  GLU   C CA    1 
ATOM   1738 C C     . GLU   A 1 369  ? 115.444 151.267 142.558 1.00 14.30  ?  369  GLU   C C     1 
ATOM   1739 O O     . GLU   A 1 369  ? 115.232 151.173 141.348 1.00 20.04  ?  369  GLU   C O     1 
ATOM   1740 C CB    . GLU   A 1 369  ? 117.903 151.299 142.968 1.00 18.18  ?  369  GLU   C CB    1 
ATOM   1741 C CG    . GLU   A 1 369  ? 117.919 152.688 143.606 1.00 21.06  ?  369  GLU   C CG    1 
ATOM   1742 C CD    . GLU   A 1 369  ? 119.197 153.433 143.390 1.00 41.92  ?  369  GLU   C CD    1 
ATOM   1743 O OE1   . GLU   A 1 369  ? 120.017 152.968 142.640 1.00 37.09  ?  369  GLU   C OE1   1 
ATOM   1744 O OE2   . GLU   A 1 369  ? 119.359 154.472 143.984 1.00 40.23  -1 369  GLU   C OE2   1 
ATOM   1745 N N     . ILE   A 1 370  ? 114.700 152.015 143.363 1.00 14.67  ?  370  ILE   C N     1 
ATOM   1746 C CA    . ILE   A 1 370  ? 113.599 152.814 142.852 1.00 12.91  ?  370  ILE   C CA    1 
ATOM   1747 C C     . ILE   A 1 370  ? 114.023 154.255 142.661 1.00 14.40  ?  370  ILE   C C     1 
ATOM   1748 O O     . ILE   A 1 370  ? 114.428 154.931 143.606 1.00 15.99  ?  370  ILE   C O     1 
ATOM   1749 C CB    . ILE   A 1 370  ? 112.384 152.778 143.792 1.00 12.77  ?  370  ILE   C CB    1 
ATOM   1750 C CG1   . ILE   A 1 370  ? 111.875 151.350 143.932 1.00 16.33  ?  370  ILE   C CG1   1 
ATOM   1751 C CG2   . ILE   A 1 370  ? 111.277 153.697 143.252 1.00 12.54  ?  370  ILE   C CG2   1 
ATOM   1752 C CD1   . ILE   A 1 370  ? 110.876 151.167 145.045 1.00 15.06  ?  370  ILE   C CD1   1 
ATOM   1753 N N     . LEU   A 1 371  ? 113.910 154.721 141.434 1.00 16.81  ?  371  LEU   C N     1 
ATOM   1754 C CA    . LEU   A 1 371  ? 114.228 156.088 141.087 1.00 16.09  ?  371  LEU   C CA    1 
ATOM   1755 C C     . LEU   A 1 371  ? 112.930 156.805 140.776 1.00 16.48  ?  371  LEU   C C     1 
ATOM   1756 O O     . LEU   A 1 371  ? 111.936 156.180 140.405 1.00 20.25  ?  371  LEU   C O     1 
ATOM   1757 C CB    . LEU   A 1 371  ? 115.182 156.139 139.892 1.00 20.57  ?  371  LEU   C CB    1 
ATOM   1758 C CG    . LEU   A 1 371  ? 116.661 155.850 140.174 1.00 23.58  ?  371  LEU   C CG    1 
ATOM   1759 C CD1   . LEU   A 1 371  ? 116.870 154.340 140.333 1.00 23.52  ?  371  LEU   C CD1   1 
ATOM   1760 C CD2   . LEU   A 1 371  ? 117.490 156.389 139.018 1.00 29.84  ?  371  LEU   C CD2   1 
ATOM   1761 N N     . GLY   A 1 372  ? 112.926 158.108 140.941 1.00 15.45  ?  372  GLY   C N     1 
ATOM   1762 C CA    . GLY   A 1 372  ? 111.697 158.862 140.796 1.00 13.46  ?  372  GLY   C CA    1 
ATOM   1763 C C     . GLY   A 1 372  ? 111.358 159.168 139.352 1.00 15.32  ?  372  GLY   C C     1 
ATOM   1764 O O     . GLY   A 1 372  ? 111.664 158.396 138.443 1.00 20.63  ?  372  GLY   C O     1 
ATOM   1765 N N     . PHE   A 1 373  ? 110.677 160.279 139.156 1.00 13.64  ?  373  PHE   C N     1 
ATOM   1766 C CA    . PHE   A 1 373  ? 110.144 160.650 137.864 1.00 13.08  ?  373  PHE   C CA    1 
ATOM   1767 C C     . PHE   A 1 373  ? 111.195 161.253 136.948 1.00 17.39  ?  373  PHE   C C     1 
ATOM   1768 O O     . PHE   A 1 373  ? 111.998 162.089 137.364 1.00 20.85  ?  373  PHE   C O     1 
ATOM   1769 C CB    . PHE   A 1 373  ? 109.035 161.683 138.054 1.00 13.98  ?  373  PHE   C CB    1 
ATOM   1770 C CG    . PHE   A 1 373  ? 107.801 161.199 138.769 1.00 10.65  ?  373  PHE   C CG    1 
ATOM   1771 C CD1   . PHE   A 1 373  ? 107.419 159.863 138.772 1.00 12.23  ?  373  PHE   C CD1   1 
ATOM   1772 C CD2   . PHE   A 1 373  ? 107.010 162.108 139.446 1.00 11.06  ?  373  PHE   C CD2   1 
ATOM   1773 C CE1   . PHE   A 1 373  ? 106.287 159.464 139.435 1.00 10.53  ?  373  PHE   C CE1   1 
ATOM   1774 C CE2   . PHE   A 1 373  ? 105.876 161.706 140.104 1.00 9.73   ?  373  PHE   C CE2   1 
ATOM   1775 C CZ    . PHE   A 1 373  ? 105.515 160.385 140.099 1.00 9.97   ?  373  PHE   C CZ    1 
ATOM   1776 N N     . SER   A 1 374  ? 111.131 160.890 135.676 1.00 18.36  ?  374  SER   C N     1 
ATOM   1777 C CA    . SER   A 1 374  ? 111.913 161.557 134.650 1.00 20.68  ?  374  SER   C CA    1 
ATOM   1778 C C     . SER   A 1 374  ? 111.218 162.866 134.331 1.00 22.50  ?  374  SER   C C     1 
ATOM   1779 O O     . SER   A 1 374  ? 110.092 163.088 134.777 1.00 24.48  ?  374  SER   C O     1 
ATOM   1780 C CB    . SER   A 1 374  ? 112.025 160.694 133.411 1.00 23.63  ?  374  SER   C CB    1 
ATOM   1781 O OG    . SER   A 1 374  ? 110.783 160.552 132.784 1.00 26.08  ?  374  SER   C OG    1 
ATOM   1782 N N     . GLU   A 1 375  ? 111.854 163.739 133.564 1.00 23.29  ?  375  GLU   C N     1 
ATOM   1783 C CA    . GLU   A 1 375  ? 111.228 165.022 133.265 1.00 23.83  ?  375  GLU   C CA    1 
ATOM   1784 C C     . GLU   A 1 375  ? 109.866 164.837 132.607 1.00 25.28  ?  375  GLU   C C     1 
ATOM   1785 O O     . GLU   A 1 375  ? 108.920 165.577 132.890 1.00 25.59  ?  375  GLU   C O     1 
ATOM   1786 C CB    . GLU   A 1 375  ? 112.140 165.857 132.374 1.00 31.18  ?  375  GLU   C CB    1 
ATOM   1787 C CG    . GLU   A 1 375  ? 113.430 166.290 133.056 1.00 29.14  ?  375  GLU   C CG    1 
ATOM   1788 C CD    . GLU   A 1 375  ? 114.484 165.223 133.048 1.00 38.40  ?  375  GLU   C CD    1 
ATOM   1789 O OE1   . GLU   A 1 375  ? 114.226 164.164 132.519 1.00 38.84  ?  375  GLU   C OE1   1 
ATOM   1790 O OE2   . GLU   A 1 375  ? 115.543 165.458 133.572 1.00 36.67  -1 375  GLU   C OE2   1 
ATOM   1791 N N     . ALA   A 1 376  ? 109.760 163.832 131.746 1.00 25.37  ?  376  ALA   C N     1 
ATOM   1792 C CA    . ALA   A 1 376  ? 108.501 163.541 131.083 1.00 25.23  ?  376  ALA   C CA    1 
ATOM   1793 C C     . ALA   A 1 376  ? 107.442 163.109 132.086 1.00 24.87  ?  376  ALA   C C     1 
ATOM   1794 O O     . ALA   A 1 376  ? 106.262 163.431 131.931 1.00 26.50  ?  376  ALA   C O     1 
ATOM   1795 C CB    . ALA   A 1 376  ? 108.692 162.455 130.041 1.00 28.46  ?  376  ALA   C CB    1 
ATOM   1796 N N     . LYS   A 1 377  ? 107.859 162.368 133.106 1.00 23.64  ?  377  LYS   C N     1 
ATOM   1797 C CA    . LYS   A 1 377  ? 106.922 161.835 134.079 1.00 22.08  ?  377  LYS   C CA    1 
ATOM   1798 C C     . LYS   A 1 377  ? 106.491 162.905 135.067 1.00 20.93  ?  377  LYS   C C     1 
ATOM   1799 O O     . LYS   A 1 377  ? 105.376 162.862 135.585 1.00 21.07  ?  377  LYS   C O     1 
ATOM   1800 C CB    . LYS   A 1 377  ? 107.526 160.627 134.787 1.00 19.96  ?  377  LYS   C CB    1 
ATOM   1801 C CG    . LYS   A 1 377  ? 107.760 159.409 133.879 1.00 23.15  ?  377  LYS   C CG    1 
ATOM   1802 C CD    . LYS   A 1 377  ? 106.444 158.758 133.440 1.00 28.88  ?  377  LYS   C CD    1 
ATOM   1803 C CE    . LYS   A 1 377  ? 106.665 157.575 132.501 1.00 34.77  ?  377  LYS   C CE    1 
ATOM   1804 N NZ    . LYS   A 1 377  ? 107.061 158.008 131.133 1.00 34.85  1  377  LYS   C NZ    1 
ATOM   1805 N N     . ARG   A 1 378  ? 107.344 163.900 135.290 1.00 21.24  ?  378  ARG   C N     1 
ATOM   1806 C CA    . ARG   A 1 378  ? 106.932 165.015 136.127 1.00 22.19  ?  378  ARG   C CA    1 
ATOM   1807 C C     . ARG   A 1 378  ? 105.741 165.699 135.477 1.00 26.64  ?  378  ARG   C C     1 
ATOM   1808 O O     . ARG   A 1 378  ? 104.733 165.965 136.130 1.00 27.39  ?  378  ARG   C O     1 
ATOM   1809 C CB    . ARG   A 1 378  ? 108.028 166.056 136.262 1.00 24.13  ?  378  ARG   C CB    1 
ATOM   1810 C CG    . ARG   A 1 378  ? 109.226 165.743 137.129 1.00 20.41  ?  378  ARG   C CG    1 
ATOM   1811 C CD    . ARG   A 1 378  ? 110.179 166.853 136.948 1.00 24.04  ?  378  ARG   C CD    1 
ATOM   1812 N NE    . ARG   A 1 378  ? 111.323 166.845 137.823 1.00 22.18  ?  378  ARG   C NE    1 
ATOM   1813 C CZ    . ARG   A 1 378  ? 112.417 166.087 137.669 1.00 20.10  ?  378  ARG   C CZ    1 
ATOM   1814 N NH1   . ARG   A 1 378  ? 112.497 165.208 136.703 1.00 21.55  1  378  ARG   C NH1   1 
ATOM   1815 N NH2   . ARG   A 1 378  ? 113.418 166.244 138.501 1.00 23.57  ?  378  ARG   C NH2   1 
ATOM   1816 N N     . LYS   A 1 379  ? 105.855 165.958 134.173 1.00 27.06  ?  379  LYS   C N     1 
ATOM   1817 C CA    . LYS   A 1 379  ? 104.787 166.620 133.435 1.00 26.56  ?  379  LYS   C CA    1 
ATOM   1818 C C     . LYS   A 1 379  ? 103.501 165.816 133.490 1.00 26.77  ?  379  LYS   C C     1 
ATOM   1819 O O     . LYS   A 1 379  ? 102.423 166.381 133.688 1.00 29.74  ?  379  LYS   C O     1 
ATOM   1820 C CB    . LYS   A 1 379  ? 105.201 166.849 131.984 1.00 31.15  ?  379  LYS   C CB    1 
ATOM   1821 C CG    . LYS   A 1 379  ? 104.203 167.668 131.169 1.00 36.68  ?  379  LYS   C CG    1 
ATOM   1822 C CD    . LYS   A 1 379  ? 104.663 167.850 129.722 1.00 33.16  ?  379  LYS   C CD    1 
ATOM   1823 C CE    . LYS   A 1 379  ? 105.744 168.920 129.601 1.00 33.44  ?  379  LYS   C CE    1 
ATOM   1824 N NZ    . LYS   A 1 379  ? 106.120 169.163 128.184 1.00 41.96  1  379  LYS   C NZ    1 
ATOM   1825 N N     . GLU   A 1 380  ? 103.610 164.498 133.339 1.00 24.89  ?  380  GLU   C N     1 
ATOM   1826 C CA    . GLU   A 1 380  ? 102.423 163.658 133.381 1.00 24.71  ?  380  GLU   C CA    1 
ATOM   1827 C C     . GLU   A 1 380  ? 101.727 163.781 134.720 1.00 26.69  ?  380  GLU   C C     1 
ATOM   1828 O O     . GLU   A 1 380  ? 100.500 163.850 134.782 1.00 29.50  ?  380  GLU   C O     1 
ATOM   1829 C CB    . GLU   A 1 380  ? 102.772 162.190 133.138 1.00 25.12  ?  380  GLU   C CB    1 
ATOM   1830 C CG    . GLU   A 1 380  ? 103.206 161.856 131.727 1.00 29.85  ?  380  GLU   C CG    1 
ATOM   1831 C CD    . GLU   A 1 380  ? 103.469 160.385 131.535 1.00 33.25  ?  380  GLU   C CD    1 
ATOM   1832 O OE1   . GLU   A 1 380  ? 103.229 159.639 132.455 1.00 30.95  ?  380  GLU   C OE1   1 
ATOM   1833 O OE2   . GLU   A 1 380  ? 103.920 160.009 130.477 1.00 35.05  -1 380  GLU   C OE2   1 
ATOM   1834 N N     . TYR   A 1 381  ? 102.505 163.828 135.794 1.00 24.96  ?  381  TYR   C N     1 
ATOM   1835 C CA    . TYR   A 1 381  ? 101.927 163.925 137.123 1.00 23.19  ?  381  TYR   C CA    1 
ATOM   1836 C C     . TYR   A 1 381  ? 101.075 165.179 137.249 1.00 24.57  ?  381  TYR   C C     1 
ATOM   1837 O O     . TYR   A 1 381  ? 99.940  165.118 137.720 1.00 26.42  ?  381  TYR   C O     1 
ATOM   1838 C CB    . TYR   A 1 381  ? 103.009 163.933 138.196 1.00 20.32  ?  381  TYR   C CB    1 
ATOM   1839 C CG    . TYR   A 1 381  ? 102.447 163.875 139.593 1.00 16.98  ?  381  TYR   C CG    1 
ATOM   1840 C CD1   . TYR   A 1 381  ? 102.181 162.644 140.159 1.00 15.37  ?  381  TYR   C CD1   1 
ATOM   1841 C CD2   . TYR   A 1 381  ? 102.182 165.034 140.301 1.00 15.39  ?  381  TYR   C CD2   1 
ATOM   1842 C CE1   . TYR   A 1 381  ? 101.661 162.566 141.427 1.00 14.26  ?  381  TYR   C CE1   1 
ATOM   1843 C CE2   . TYR   A 1 381  ? 101.657 164.949 141.575 1.00 13.25  ?  381  TYR   C CE2   1 
ATOM   1844 C CZ    . TYR   A 1 381  ? 101.400 163.723 142.133 1.00 12.95  ?  381  TYR   C CZ    1 
ATOM   1845 O OH    . TYR   A 1 381  ? 100.879 163.636 143.401 1.00 16.51  ?  381  TYR   C OH    1 
ATOM   1846 N N     . PHE   A 1 382  ? 101.617 166.315 136.823 1.00 24.57  ?  382  PHE   C N     1 
ATOM   1847 C CA    . PHE   A 1 382  ? 100.901 167.578 136.949 1.00 27.59  ?  382  PHE   C CA    1 
ATOM   1848 C C     . PHE   A 1 382  ? 99.631  167.575 136.119 1.00 32.06  ?  382  PHE   C C     1 
ATOM   1849 O O     . PHE   A 1 382  ? 98.592  168.081 136.550 1.00 32.87  ?  382  PHE   C O     1 
ATOM   1850 C CB    . PHE   A 1 382  ? 101.795 168.739 136.522 1.00 28.72  ?  382  PHE   C CB    1 
ATOM   1851 C CG    . PHE   A 1 382  ? 102.876 168.995 137.503 1.00 30.21  ?  382  PHE   C CG    1 
ATOM   1852 C CD1   . PHE   A 1 382  ? 104.175 168.635 137.226 1.00 30.80  ?  382  PHE   C CD1   1 
ATOM   1853 C CD2   . PHE   A 1 382  ? 102.597 169.577 138.716 1.00 29.41  ?  382  PHE   C CD2   1 
ATOM   1854 C CE1   . PHE   A 1 382  ? 105.177 168.843 138.138 1.00 27.89  ?  382  PHE   C CE1   1 
ATOM   1855 C CE2   . PHE   A 1 382  ? 103.593 169.787 139.632 1.00 30.06  ?  382  PHE   C CE2   1 
ATOM   1856 C CZ    . PHE   A 1 382  ? 104.888 169.415 139.342 1.00 27.20  ?  382  PHE   C CZ    1 
ATOM   1857 N N     . PHE   A 1 383  ? 99.714  166.993 134.929 1.00 32.22  ?  383  PHE   C N     1 
ATOM   1858 C CA    . PHE   A 1 383  ? 98.574  166.940 134.027 1.00 31.56  ?  383  PHE   C CA    1 
ATOM   1859 C C     . PHE   A 1 383  ? 97.500  165.993 134.540 1.00 30.97  ?  383  PHE   C C     1 
ATOM   1860 O O     . PHE   A 1 383  ? 96.316  166.203 134.289 1.00 35.42  ?  383  PHE   C O     1 
ATOM   1861 C CB    . PHE   A 1 383  ? 99.023  166.530 132.628 1.00 31.39  ?  383  PHE   C CB    1 
ATOM   1862 C CG    . PHE   A 1 383  ? 99.825  167.598 131.884 1.00 35.78  ?  383  PHE   C CG    1 
ATOM   1863 C CD1   . PHE   A 1 383  ? 100.166 168.822 132.476 1.00 35.69  ?  383  PHE   C CD1   1 
ATOM   1864 C CD2   . PHE   A 1 383  ? 100.232 167.377 130.582 1.00 39.89  ?  383  PHE   C CD2   1 
ATOM   1865 C CE1   . PHE   A 1 383  ? 100.878 169.768 131.784 1.00 38.16  ?  383  PHE   C CE1   1 
ATOM   1866 C CE2   . PHE   A 1 383  ? 100.946 168.329 129.888 1.00 38.77  ?  383  PHE   C CE2   1 
ATOM   1867 C CZ    . PHE   A 1 383  ? 101.269 169.526 130.491 1.00 41.66  ?  383  PHE   C CZ    1 
ATOM   1868 N N     . LYS   A 1 384  ? 97.906  164.955 135.262 1.00 28.91  ?  384  LYS   C N     1 
ATOM   1869 C CA    . LYS   A 1 384  ? 96.941  164.031 135.838 1.00 26.89  ?  384  LYS   C CA    1 
ATOM   1870 C C     . LYS   A 1 384  ? 96.356  164.579 137.134 1.00 30.12  ?  384  LYS   C C     1 
ATOM   1871 O O     . LYS   A 1 384  ? 95.192  164.333 137.448 1.00 34.55  ?  384  LYS   C O     1 
ATOM   1872 C CB    . LYS   A 1 384  ? 97.587  162.667 136.071 1.00 27.16  ?  384  LYS   C CB    1 
ATOM   1873 C CG    . LYS   A 1 384  ? 97.897  161.916 134.789 1.00 30.85  ?  384  LYS   C CG    1 
ATOM   1874 C CD    . LYS   A 1 384  ? 98.592  160.592 135.057 1.00 32.85  ?  384  LYS   C CD    1 
ATOM   1875 C CE    . LYS   A 1 384  ? 98.921  159.878 133.749 1.00 40.41  ?  384  LYS   C CE    1 
ATOM   1876 N NZ    . LYS   A 1 384  ? 99.650  158.608 133.976 1.00 32.91  1  384  LYS   C NZ    1 
ATOM   1877 N N     . TYR   A 1 385  ? 97.163  165.321 137.889 1.00 31.39  ?  385  TYR   C N     1 
ATOM   1878 C CA    . TYR   A 1 385  ? 96.712  165.891 139.154 1.00 32.75  ?  385  TYR   C CA    1 
ATOM   1879 C C     . TYR   A 1 385  ? 95.632  166.944 138.944 1.00 33.25  ?  385  TYR   C C     1 
ATOM   1880 O O     . TYR   A 1 385  ? 94.589  166.914 139.597 1.00 35.86  ?  385  TYR   C O     1 
ATOM   1881 C CB    . TYR   A 1 385  ? 97.879  166.518 139.922 1.00 29.19  ?  385  TYR   C CB    1 
ATOM   1882 C CG    . TYR   A 1 385  ? 97.482  167.039 141.295 1.00 29.24  ?  385  TYR   C CG    1 
ATOM   1883 C CD1   . TYR   A 1 385  ? 97.725  166.276 142.425 1.00 28.39  ?  385  TYR   C CD1   1 
ATOM   1884 C CD2   . TYR   A 1 385  ? 96.859  168.268 141.421 1.00 29.67  ?  385  TYR   C CD2   1 
ATOM   1885 C CE1   . TYR   A 1 385  ? 97.346  166.742 143.666 1.00 26.51  ?  385  TYR   C CE1   1 
ATOM   1886 C CE2   . TYR   A 1 385  ? 96.482  168.733 142.655 1.00 29.48  ?  385  TYR   C CE2   1 
ATOM   1887 C CZ    . TYR   A 1 385  ? 96.722  167.977 143.777 1.00 25.92  ?  385  TYR   C CZ    1 
ATOM   1888 O OH    . TYR   A 1 385  ? 96.346  168.442 145.013 1.00 31.90  ?  385  TYR   C OH    1 
ATOM   1889 N N     . PHE   A 1 386  ? 95.895  167.893 138.051 1.00 33.65  ?  386  PHE   C N     1 
ATOM   1890 C CA    . PHE   A 1 386  ? 94.963  168.987 137.820 1.00 36.15  ?  386  PHE   C CA    1 
ATOM   1891 C C     . PHE   A 1 386  ? 94.009  168.667 136.681 1.00 42.80  ?  386  PHE   C C     1 
ATOM   1892 O O     . PHE   A 1 386  ? 94.410  168.616 135.521 1.00 41.84  ?  386  PHE   C O     1 
ATOM   1893 C CB    . PHE   A 1 386  ? 95.720  170.277 137.500 1.00 37.57  ?  386  PHE   C CB    1 
ATOM   1894 C CG    . PHE   A 1 386  ? 96.476  170.859 138.651 1.00 38.39  ?  386  PHE   C CG    1 
ATOM   1895 C CD1   . PHE   A 1 386  ? 97.814  170.552 138.842 1.00 34.33  ?  386  PHE   C CD1   1 
ATOM   1896 C CD2   . PHE   A 1 386  ? 95.858  171.717 139.550 1.00 41.88  ?  386  PHE   C CD2   1 
ATOM   1897 C CE1   . PHE   A 1 386  ? 98.515  171.083 139.904 1.00 35.00  ?  386  PHE   C CE1   1 
ATOM   1898 C CE2   . PHE   A 1 386  ? 96.559  172.248 140.616 1.00 39.23  ?  386  PHE   C CE2   1 
ATOM   1899 C CZ    . PHE   A 1 386  ? 97.888  171.930 140.791 1.00 34.85  ?  386  PHE   C CZ    1 
ATOM   1900 N N     . SER   A 1 387  ? 92.733  168.474 137.014 1.00 47.87  ?  387  SER   C N     1 
ATOM   1901 C CA    . SER   A 1 387  ? 91.726  168.127 136.017 1.00 48.28  ?  387  SER   C CA    1 
ATOM   1902 C C     . SER   A 1 387  ? 91.520  169.268 135.029 1.00 42.65  ?  387  SER   C C     1 
ATOM   1903 O O     . SER   A 1 387  ? 91.172  169.048 133.869 1.00 46.17  ?  387  SER   C O     1 
ATOM   1904 C CB    . SER   A 1 387  ? 90.415  167.791 136.700 1.00 53.41  ?  387  SER   C CB    1 
ATOM   1905 O OG    . SER   A 1 387  ? 89.893  168.916 137.357 1.00 48.49  ?  387  SER   C OG    1 
ATOM   1906 N N     . ASP   A 1 388  ? 91.780  170.485 135.485 1.00 44.27  ?  388  ASP   C N     1 
ATOM   1907 C CA    . ASP   A 1 388  ? 91.731  171.653 134.623 1.00 44.73  ?  388  ASP   C CA    1 
ATOM   1908 C C     . ASP   A 1 388  ? 93.057  171.808 133.897 1.00 46.31  ?  388  ASP   C C     1 
ATOM   1909 O O     . ASP   A 1 388  ? 94.090  172.064 134.518 1.00 51.17  ?  388  ASP   C O     1 
ATOM   1910 C CB    . ASP   A 1 388  ? 91.403  172.913 135.421 1.00 47.49  ?  388  ASP   C CB    1 
ATOM   1911 C CG    . ASP   A 1 388  ? 91.355  174.171 134.548 1.00 49.20  ?  388  ASP   C CG    1 
ATOM   1912 O OD1   . ASP   A 1 388  ? 92.121  174.240 133.604 1.00 46.06  ?  388  ASP   C OD1   1 
ATOM   1913 O OD2   . ASP   A 1 388  ? 90.569  175.045 134.825 1.00 47.34  -1 388  ASP   C OD2   1 
ATOM   1914 N N     . GLU   A 1 389  ? 93.027  171.603 132.586 1.00 42.70  ?  389  GLU   C N     1 
ATOM   1915 C CA    . GLU   A 1 389  ? 94.233  171.617 131.775 1.00 42.25  ?  389  GLU   C CA    1 
ATOM   1916 C C     . GLU   A 1 389  ? 94.923  172.973 131.791 1.00 42.99  ?  389  GLU   C C     1 
ATOM   1917 O O     . GLU   A 1 389  ? 96.147  173.049 131.686 1.00 42.59  ?  389  GLU   C O     1 
ATOM   1918 C CB    . GLU   A 1 389  ? 93.908  171.220 130.340 1.00 50.86  ?  389  GLU   C CB    1 
ATOM   1919 C CG    . GLU   A 1 389  ? 93.526  169.762 130.167 1.00 51.13  ?  389  GLU   C CG    1 
ATOM   1920 C CD    . GLU   A 1 389  ? 93.207  169.414 128.746 1.00 57.03  ?  389  GLU   C CD    1 
ATOM   1921 O OE1   . GLU   A 1 389  ? 93.037  170.314 127.957 1.00 53.41  ?  389  GLU   C OE1   1 
ATOM   1922 O OE2   . GLU   A 1 389  ? 93.134  168.248 128.444 1.00 71.69  -1 389  GLU   C OE2   1 
ATOM   1923 N N     . ALA   A 1 390  ? 94.148  174.049 131.883 1.00 42.41  ?  390  ALA   C N     1 
ATOM   1924 C CA    . ALA   A 1 390  ? 94.737  175.379 131.884 1.00 45.00  ?  390  ALA   C CA    1 
ATOM   1925 C C     . ALA   A 1 390  ? 95.540  175.573 133.154 1.00 44.19  ?  390  ALA   C C     1 
ATOM   1926 O O     . ALA   A 1 390  ? 96.620  176.169 133.141 1.00 45.29  ?  390  ALA   C O     1 
ATOM   1927 C CB    . ALA   A 1 390  ? 93.659  176.440 131.765 1.00 50.31  ?  390  ALA   C CB    1 
ATOM   1928 N N     . GLN   A 1 391  ? 95.007  175.045 134.249 1.00 43.17  ?  391  GLN   C N     1 
ATOM   1929 C CA    . GLN   A 1 391  ? 95.690  175.122 135.532 1.00 43.59  ?  391  GLN   C CA    1 
ATOM   1930 C C     . GLN   A 1 391  ? 96.907  174.213 135.537 1.00 41.22  ?  391  GLN   C C     1 
ATOM   1931 O O     . GLN   A 1 391  ? 97.957  174.574 136.070 1.00 38.79  ?  391  GLN   C O     1 
ATOM   1932 C CB    . GLN   A 1 391  ? 94.752  174.737 136.672 1.00 43.84  ?  391  GLN   C CB    1 
ATOM   1933 C CG    . GLN   A 1 391  ? 93.643  175.736 136.934 1.00 48.06  ?  391  GLN   C CG    1 
ATOM   1934 C CD    . GLN   A 1 391  ? 92.718  175.263 138.023 1.00 51.23  ?  391  GLN   C CD    1 
ATOM   1935 O OE1   . GLN   A 1 391  ? 92.800  174.110 138.454 1.00 46.02  ?  391  GLN   C OE1   1 
ATOM   1936 N NE2   . GLN   A 1 391  ? 91.831  176.139 138.478 1.00 55.18  ?  391  GLN   C NE2   1 
ATOM   1937 N N     . ALA   A 1 392  ? 96.773  173.037 134.923 1.00 40.19  ?  392  ALA   C N     1 
ATOM   1938 C CA    . ALA   A 1 392  ? 97.855  172.066 134.878 1.00 38.37  ?  392  ALA   C CA    1 
ATOM   1939 C C     . ALA   A 1 392  ? 99.064  172.641 134.158 1.00 39.75  ?  392  ALA   C C     1 
ATOM   1940 O O     . ALA   A 1 392  ? 100.203 172.429 134.569 1.00 41.09  ?  392  ALA   C O     1 
ATOM   1941 C CB    . ALA   A 1 392  ? 97.405  170.800 134.175 1.00 37.84  ?  392  ALA   C CB    1 
ATOM   1942 N N     . ARG   A 1 393  ? 98.805  173.366 133.073 1.00 39.30  ?  393  ARG   C N     1 
ATOM   1943 C CA    . ARG   A 1 393  ? 99.881  173.975 132.310 1.00 38.66  ?  393  ARG   C CA    1 
ATOM   1944 C C     . ARG   A 1 393  ? 100.513 175.127 133.070 1.00 38.06  ?  393  ARG   C C     1 
ATOM   1945 O O     . ARG   A 1 393  ? 101.736 175.259 133.095 1.00 40.00  ?  393  ARG   C O     1 
ATOM   1946 C CB    . ARG   A 1 393  ? 99.370  174.464 130.966 1.00 44.47  ?  393  ARG   C CB    1 
ATOM   1947 C CG    . ARG   A 1 393  ? 99.058  173.363 129.965 1.00 46.82  ?  393  ARG   C CG    1 
ATOM   1948 C CD    . ARG   A 1 393  ? 98.855  173.909 128.609 1.00 41.50  ?  393  ARG   C CD    1 
ATOM   1949 N NE    . ARG   A 1 393  ? 97.703  174.799 128.554 1.00 41.51  ?  393  ARG   C NE    1 
ATOM   1950 C CZ    . ARG   A 1 393  ? 96.430  174.410 128.343 1.00 39.25  ?  393  ARG   C CZ    1 
ATOM   1951 N NH1   . ARG   A 1 393  ? 96.140  173.141 128.168 1.00 37.97  1  393  ARG   C NH1   1 
ATOM   1952 N NH2   . ARG   A 1 393  ? 95.469  175.315 128.311 1.00 44.26  ?  393  ARG   C NH2   1 
ATOM   1953 N N     . ALA   A 1 394  ? 99.686  175.951 133.709 1.00 38.07  ?  394  ALA   C N     1 
ATOM   1954 C CA    . ALA   A 1 394  ? 100.204 177.070 134.483 1.00 39.83  ?  394  ALA   C CA    1 
ATOM   1955 C C     . ALA   A 1 394  ? 101.072 176.571 135.625 1.00 41.02  ?  394  ALA   C C     1 
ATOM   1956 O O     . ALA   A 1 394  ? 102.130 177.142 135.907 1.00 38.38  ?  394  ALA   C O     1 
ATOM   1957 C CB    . ALA   A 1 394  ? 99.056  177.894 135.037 1.00 45.49  ?  394  ALA   C CB    1 
ATOM   1958 N N     . ALA   A 1 395  ? 100.629 175.505 136.283 1.00 41.02  ?  395  ALA   C N     1 
ATOM   1959 C CA    . ALA   A 1 395  ? 101.370 174.950 137.399 1.00 37.19  ?  395  ALA   C CA    1 
ATOM   1960 C C     . ALA   A 1 395  ? 102.687 174.381 136.922 1.00 35.67  ?  395  ALA   C C     1 
ATOM   1961 O O     . ALA   A 1 395  ? 103.729 174.610 137.534 1.00 37.04  ?  395  ALA   C O     1 
ATOM   1962 C CB    . ALA   A 1 395  ? 100.560 173.869 138.094 1.00 37.44  ?  395  ALA   C CB    1 
ATOM   1963 N N     . PHE   A 1 396  ? 102.646 173.661 135.805 1.00 34.78  ?  396  PHE   C N     1 
ATOM   1964 C CA    . PHE   A 1 396  ? 103.858 173.061 135.288 1.00 33.06  ?  396  PHE   C CA    1 
ATOM   1965 C C     . PHE   A 1 396  ? 104.876 174.130 134.948 1.00 34.77  ?  396  PHE   C C     1 
ATOM   1966 O O     . PHE   A 1 396  ? 106.044 174.011 135.317 1.00 37.61  ?  396  PHE   C O     1 
ATOM   1967 C CB    . PHE   A 1 396  ? 103.584 172.213 134.052 1.00 34.52  ?  396  PHE   C CB    1 
ATOM   1968 C CG    . PHE   A 1 396  ? 104.831 171.570 133.548 1.00 33.99  ?  396  PHE   C CG    1 
ATOM   1969 C CD1   . PHE   A 1 396  ? 105.273 170.393 134.111 1.00 32.76  ?  396  PHE   C CD1   1 
ATOM   1970 C CD2   . PHE   A 1 396  ? 105.582 172.148 132.540 1.00 36.80  ?  396  PHE   C CD2   1 
ATOM   1971 C CE1   . PHE   A 1 396  ? 106.432 169.800 133.687 1.00 31.82  ?  396  PHE   C CE1   1 
ATOM   1972 C CE2   . PHE   A 1 396  ? 106.748 171.554 132.113 1.00 41.43  ?  396  PHE   C CE2   1 
ATOM   1973 C CZ    . PHE   A 1 396  ? 107.170 170.377 132.688 1.00 37.41  ?  396  PHE   C CZ    1 
ATOM   1974 N N     . SER   A 1 397  ? 104.441 175.172 134.240 1.00 35.99  ?  397  SER   C N     1 
ATOM   1975 C CA    . SER   A 1 397  ? 105.348 176.230 133.818 1.00 36.53  ?  397  SER   C CA    1 
ATOM   1976 C C     . SER   A 1 397  ? 105.958 176.958 135.003 1.00 37.74  ?  397  SER   C C     1 
ATOM   1977 O O     . SER   A 1 397  ? 107.155 177.244 135.011 1.00 38.89  ?  397  SER   C O     1 
ATOM   1978 C CB    . SER   A 1 397  ? 104.621 177.226 132.937 1.00 43.45  ?  397  SER   C CB    1 
ATOM   1979 O OG    . SER   A 1 397  ? 104.256 176.650 131.714 1.00 42.44  ?  397  SER   C OG    1 
ATOM   1980 N N     . LEU   A 1 398  ? 105.151 177.231 136.021 1.00 36.53  ?  398  LEU   C N     1 
ATOM   1981 C CA    . LEU   A 1 398  ? 105.657 177.920 137.195 1.00 36.82  ?  398  LEU   C CA    1 
ATOM   1982 C C     . LEU   A 1 398  ? 106.790 177.136 137.837 1.00 36.47  ?  398  LEU   C C     1 
ATOM   1983 O O     . LEU   A 1 398  ? 107.793 177.707 138.265 1.00 36.98  ?  398  LEU   C O     1 
ATOM   1984 C CB    . LEU   A 1 398  ? 104.534 178.115 138.215 1.00 38.57  ?  398  LEU   C CB    1 
ATOM   1985 C CG    . LEU   A 1 398  ? 104.931 178.789 139.534 1.00 41.65  ?  398  LEU   C CG    1 
ATOM   1986 C CD1   . LEU   A 1 398  ? 105.448 180.204 139.274 1.00 44.74  ?  398  LEU   C CD1   1 
ATOM   1987 C CD2   . LEU   A 1 398  ? 103.731 178.812 140.445 1.00 40.02  ?  398  LEU   C CD2   1 
ATOM   1988 N N     . ILE   A 1 399  ? 106.615 175.823 137.912 1.00 34.74  ?  399  ILE   C N     1 
ATOM   1989 C CA    . ILE   A 1 399  ? 107.612 174.939 138.495 1.00 33.53  ?  399  ILE   C CA    1 
ATOM   1990 C C     . ILE   A 1 399  ? 108.808 174.759 137.568 1.00 31.16  ?  399  ILE   C C     1 
ATOM   1991 O O     . ILE   A 1 399  ? 109.948 174.771 138.014 1.00 31.36  ?  399  ILE   C O     1 
ATOM   1992 C CB    . ILE   A 1 399  ? 106.985 173.585 138.839 1.00 33.13  ?  399  ILE   C CB    1 
ATOM   1993 C CG1   . ILE   A 1 399  ? 105.940 173.810 139.922 1.00 34.32  ?  399  ILE   C CG1   1 
ATOM   1994 C CG2   . ILE   A 1 399  ? 108.063 172.601 139.309 1.00 26.54  ?  399  ILE   C CG2   1 
ATOM   1995 C CD1   . ILE   A 1 399  ? 105.023 172.660 140.118 1.00 32.55  ?  399  ILE   C CD1   1 
ATOM   1996 N N     . GLN   A 1 400  ? 108.557 174.603 136.274 1.00 33.16  ?  400  GLN   C N     1 
ATOM   1997 C CA    . GLN   A 1 400  ? 109.638 174.418 135.311 1.00 31.36  ?  400  GLN   C CA    1 
ATOM   1998 C C     . GLN   A 1 400  ? 110.632 175.573 135.383 1.00 33.17  ?  400  GLN   C C     1 
ATOM   1999 O O     . GLN   A 1 400  ? 111.838 175.369 135.242 1.00 33.41  ?  400  GLN   C O     1 
ATOM   2000 C CB    . GLN   A 1 400  ? 109.073 174.305 133.891 1.00 34.99  ?  400  GLN   C CB    1 
ATOM   2001 C CG    . GLN   A 1 400  ? 110.113 174.031 132.804 1.00 37.65  ?  400  GLN   C CG    1 
ATOM   2002 C CD    . GLN   A 1 400  ? 110.734 172.653 132.894 1.00 34.11  ?  400  GLN   C CD    1 
ATOM   2003 O OE1   . GLN   A 1 400  ? 110.074 171.648 132.626 1.00 32.28  ?  400  GLN   C OE1   1 
ATOM   2004 N NE2   . GLN   A 1 400  ? 112.002 172.599 133.275 1.00 35.46  ?  400  GLN   C NE2   1 
ATOM   2005 N N     . GLU   A 1 401  ? 110.128 176.781 135.622 1.00 34.57  ?  401  GLU   C N     1 
ATOM   2006 C CA    . GLU   A 1 401  ? 110.971 177.966 135.754 1.00 35.87  ?  401  GLU   C CA    1 
ATOM   2007 C C     . GLU   A 1 401  ? 111.828 177.944 137.024 1.00 33.91  ?  401  GLU   C C     1 
ATOM   2008 O O     . GLU   A 1 401  ? 112.811 178.678 137.128 1.00 34.77  ?  401  GLU   C O     1 
ATOM   2009 C CB    . GLU   A 1 401  ? 110.115 179.232 135.730 1.00 42.18  ?  401  GLU   C CB    1 
ATOM   2010 C CG    . GLU   A 1 401  ? 109.505 179.548 134.374 1.00 45.93  ?  401  GLU   C CG    1 
ATOM   2011 C CD    . GLU   A 1 401  ? 108.649 180.781 134.391 1.00 55.22  ?  401  GLU   C CD    1 
ATOM   2012 O OE1   . GLU   A 1 401  ? 108.463 181.339 135.446 1.00 49.07  ?  401  GLU   C OE1   1 
ATOM   2013 O OE2   . GLU   A 1 401  ? 108.178 181.166 133.347 1.00 55.26  -1 401  GLU   C OE2   1 
ATOM   2014 N N     . ASN   A 1 402  ? 111.438 177.127 137.998 1.00 34.69  ?  402  ASN   C N     1 
ATOM   2015 C CA    . ASN   A 1 402  ? 112.163 176.996 139.255 1.00 30.69  ?  402  ASN   C CA    1 
ATOM   2016 C C     . ASN   A 1 402  ? 113.062 175.769 139.170 1.00 27.31  ?  402  ASN   C C     1 
ATOM   2017 O O     . ASN   A 1 402  ? 112.650 174.655 139.494 1.00 27.04  ?  402  ASN   C O     1 
ATOM   2018 C CB    . ASN   A 1 402  ? 111.185 176.916 140.420 1.00 28.93  ?  402  ASN   C CB    1 
ATOM   2019 C CG    . ASN   A 1 402  ? 111.842 176.836 141.779 1.00 29.17  ?  402  ASN   C CG    1 
ATOM   2020 O OD1   . ASN   A 1 402  ? 112.996 176.399 141.900 1.00 30.31  ?  402  ASN   C OD1   1 
ATOM   2021 N ND2   . ASN   A 1 402  ? 111.123 177.235 142.813 1.00 28.79  ?  402  ASN   C ND2   1 
ATOM   2022 N N     . GLU   A 1 403  ? 114.288 175.971 138.702 1.00 29.48  ?  403  GLU   C N     1 
ATOM   2023 C CA    . GLU   A 1 403  ? 115.181 174.860 138.389 1.00 27.93  ?  403  GLU   C CA    1 
ATOM   2024 C C     . GLU   A 1 403  ? 115.415 173.961 139.589 1.00 28.60  ?  403  GLU   C C     1 
ATOM   2025 O O     . GLU   A 1 403  ? 115.494 172.735 139.462 1.00 27.91  ?  403  GLU   C O     1 
ATOM   2026 C CB    . GLU   A 1 403  ? 116.523 175.400 137.895 1.00 35.34  ?  403  GLU   C CB    1 
ATOM   2027 C CG    . GLU   A 1 403  ? 117.525 174.339 137.464 1.00 40.99  ?  403  GLU   C CG    1 
ATOM   2028 C CD    . GLU   A 1 403  ? 117.107 173.607 136.224 1.00 41.35  ?  403  GLU   C CD    1 
ATOM   2029 O OE1   . GLU   A 1 403  ? 116.311 174.135 135.487 1.00 41.54  ?  403  GLU   C OE1   1 
ATOM   2030 O OE2   . GLU   A 1 403  ? 117.581 172.518 136.008 1.00 38.36  -1 403  GLU   C OE2   1 
ATOM   2031 N N     . VAL   A 1 404  ? 115.537 174.575 140.753 1.00 27.16  ?  404  VAL   C N     1 
ATOM   2032 C CA    . VAL   A 1 404  ? 115.820 173.843 141.969 1.00 23.93  ?  404  VAL   C CA    1 
ATOM   2033 C C     . VAL   A 1 404  ? 114.645 172.972 142.386 1.00 21.76  ?  404  VAL   C C     1 
ATOM   2034 O O     . VAL   A 1 404  ? 114.821 171.797 142.709 1.00 21.25  ?  404  VAL   C O     1 
ATOM   2035 C CB    . VAL   A 1 404  ? 116.190 174.833 143.081 1.00 22.09  ?  404  VAL   C CB    1 
ATOM   2036 C CG1   . VAL   A 1 404  ? 116.315 174.128 144.385 1.00 23.08  ?  404  VAL   C CG1   1 
ATOM   2037 C CG2   . VAL   A 1 404  ? 117.499 175.511 142.720 1.00 26.04  ?  404  VAL   C CG2   1 
ATOM   2038 N N     . LEU   A 1 405  ? 113.445 173.538 142.363 1.00 23.46  ?  405  LEU   C N     1 
ATOM   2039 C CA    . LEU   A 1 405  ? 112.260 172.779 142.726 1.00 20.12  ?  405  LEU   C CA    1 
ATOM   2040 C C     . LEU   A 1 405  ? 111.974 171.700 141.701 1.00 19.80  ?  405  LEU   C C     1 
ATOM   2041 O O     . LEU   A 1 405  ? 111.595 170.584 142.055 1.00 18.74  ?  405  LEU   C O     1 
ATOM   2042 C CB    . LEU   A 1 405  ? 111.052 173.700 142.858 1.00 21.31  ?  405  LEU   C CB    1 
ATOM   2043 C CG    . LEU   A 1 405  ? 109.727 173.040 143.268 1.00 23.31  ?  405  LEU   C CG    1 
ATOM   2044 C CD1   . LEU   A 1 405  ? 109.886 172.343 144.616 1.00 21.47  ?  405  LEU   C CD1   1 
ATOM   2045 C CD2   . LEU   A 1 405  ? 108.667 174.109 143.338 1.00 26.33  ?  405  LEU   C CD2   1 
ATOM   2046 N N     . PHE   A 1 406  ? 112.157 172.027 140.431 1.00 22.32  ?  406  PHE   C N     1 
ATOM   2047 C CA    . PHE   A 1 406  ? 111.926 171.065 139.373 1.00 21.07  ?  406  PHE   C CA    1 
ATOM   2048 C C     . PHE   A 1 406  ? 112.810 169.849 139.608 1.00 20.66  ?  406  PHE   C C     1 
ATOM   2049 O O     . PHE   A 1 406  ? 112.358 168.709 139.500 1.00 20.12  ?  406  PHE   C O     1 
ATOM   2050 C CB    . PHE   A 1 406  ? 112.200 171.693 138.009 1.00 23.57  ?  406  PHE   C CB    1 
ATOM   2051 C CG    . PHE   A 1 406  ? 111.848 170.816 136.851 1.00 24.83  ?  406  PHE   C CG    1 
ATOM   2052 C CD1   . PHE   A 1 406  ? 110.542 170.736 136.401 1.00 26.09  ?  406  PHE   C CD1   1 
ATOM   2053 C CD2   . PHE   A 1 406  ? 112.812 170.070 136.207 1.00 25.71  ?  406  PHE   C CD2   1 
ATOM   2054 C CE1   . PHE   A 1 406  ? 110.213 169.935 135.336 1.00 26.11  ?  406  PHE   C CE1   1 
ATOM   2055 C CE2   . PHE   A 1 406  ? 112.486 169.268 135.142 1.00 26.22  ?  406  PHE   C CE2   1 
ATOM   2056 C CZ    . PHE   A 1 406  ? 111.184 169.201 134.704 1.00 24.78  ?  406  PHE   C CZ    1 
ATOM   2057 N N     . THR   A 1 407  ? 114.071 170.091 139.957 1.00 21.05  ?  407  THR   C N     1 
ATOM   2058 C CA    . THR   A 1 407  ? 114.991 169.006 140.264 1.00 19.73  ?  407  THR   C CA    1 
ATOM   2059 C C     . THR   A 1 407  ? 114.484 168.167 141.433 1.00 19.00  ?  407  THR   C C     1 
ATOM   2060 O O     . THR   A 1 407  ? 114.459 166.941 141.355 1.00 19.17  ?  407  THR   C O     1 
ATOM   2061 C CB    . THR   A 1 407  ? 116.395 169.546 140.588 1.00 21.72  ?  407  THR   C CB    1 
ATOM   2062 O OG1   . THR   A 1 407  ? 116.923 170.221 139.434 1.00 25.56  ?  407  THR   C OG1   1 
ATOM   2063 C CG2   . THR   A 1 407  ? 117.328 168.401 140.989 1.00 17.86  ?  407  THR   C CG2   1 
ATOM   2064 N N     . MET   A 1 408  ? 114.045 168.823 142.508 1.00 18.27  ?  408  MET   C N     1 
ATOM   2065 C CA    . MET   A 1 408  ? 113.548 168.105 143.679 1.00 14.12  ?  408  MET   C CA    1 
ATOM   2066 C C     . MET   A 1 408  ? 112.297 167.298 143.363 1.00 14.84  ?  408  MET   C C     1 
ATOM   2067 O O     . MET   A 1 408  ? 112.063 166.244 143.958 1.00 15.73  ?  408  MET   C O     1 
ATOM   2068 C CB    . MET   A 1 408  ? 113.259 169.069 144.824 1.00 14.07  ?  408  MET   C CB    1 
ATOM   2069 C CG    . MET   A 1 408  ? 114.495 169.661 145.469 1.00 15.96  ?  408  MET   C CG    1 
ATOM   2070 S SD    . MET   A 1 408  ? 114.136 170.539 147.007 1.00 21.44  ?  408  MET   C SD    1 
ATOM   2071 C CE    . MET   A 1 408  ? 113.301 171.998 146.433 1.00 21.07  ?  408  MET   C CE    1 
ATOM   2072 N N     . CYS   A 1 409  ? 111.508 167.776 142.409 1.00 17.52  ?  409  CYS   C N     1 
ATOM   2073 C CA    . CYS   A 1 409  ? 110.252 167.139 142.046 1.00 14.73  ?  409  CYS   C CA    1 
ATOM   2074 C C     . CYS   A 1 409  ? 110.408 165.750 141.440 1.00 14.82  ?  409  CYS   C C     1 
ATOM   2075 O O     . CYS   A 1 409  ? 109.412 165.100 141.141 1.00 16.81  ?  409  CYS   C O     1 
ATOM   2076 C CB    . CYS   A 1 409  ? 109.462 168.005 141.071 1.00 15.92  ?  409  CYS   C CB    1 
ATOM   2077 S SG    . CYS   A 1 409  ? 108.751 169.486 141.803 1.00 18.29  ?  409  CYS   C SG    1 
ATOM   2078 N N     . PHE   A 1 410  ? 111.633 165.258 141.282 1.00 15.14  ?  410  PHE   C N     1 
ATOM   2079 C CA    . PHE   A 1 410  ? 111.772 163.885 140.807 1.00 13.70  ?  410  PHE   C CA    1 
ATOM   2080 C C     . PHE   A 1 410  ? 111.144 162.938 141.820 1.00 12.50  ?  410  PHE   C C     1 
ATOM   2081 O O     . PHE   A 1 410  ? 110.745 161.826 141.482 1.00 13.47  ?  410  PHE   C O     1 
ATOM   2082 C CB    . PHE   A 1 410  ? 113.234 163.507 140.546 1.00 15.33  ?  410  PHE   C CB    1 
ATOM   2083 C CG    . PHE   A 1 410  ? 114.023 163.032 141.725 1.00 15.46  ?  410  PHE   C CG    1 
ATOM   2084 C CD1   . PHE   A 1 410  ? 114.117 161.681 142.006 1.00 14.03  ?  410  PHE   C CD1   1 
ATOM   2085 C CD2   . PHE   A 1 410  ? 114.692 163.914 142.541 1.00 15.61  ?  410  PHE   C CD2   1 
ATOM   2086 C CE1   . PHE   A 1 410  ? 114.856 161.232 143.072 1.00 12.93  ?  410  PHE   C CE1   1 
ATOM   2087 C CE2   . PHE   A 1 410  ? 115.429 163.472 143.600 1.00 13.03  ?  410  PHE   C CE2   1 
ATOM   2088 C CZ    . PHE   A 1 410  ? 115.514 162.126 143.869 1.00 13.17  ?  410  PHE   C CZ    1 
ATOM   2089 N N     . ILE   A 1 411  ? 111.041 163.392 143.066 1.00 13.35  ?  411  ILE   C N     1 
ATOM   2090 C CA    . ILE   A 1 411  ? 110.420 162.616 144.120 1.00 11.84  ?  411  ILE   C CA    1 
ATOM   2091 C C     . ILE   A 1 411  ? 108.904 162.856 144.110 1.00 10.66  ?  411  ILE   C C     1 
ATOM   2092 O O     . ILE   A 1 411  ? 108.463 163.979 144.361 1.00 11.50  ?  411  ILE   C O     1 
ATOM   2093 C CB    . ILE   A 1 411  ? 110.994 163.028 145.480 1.00 11.49  ?  411  ILE   C CB    1 
ATOM   2094 C CG1   . ILE   A 1 411  ? 112.485 162.774 145.488 1.00 11.40  ?  411  ILE   C CG1   1 
ATOM   2095 C CG2   . ILE   A 1 411  ? 110.306 162.263 146.592 1.00 10.10  ?  411  ILE   C CG2   1 
ATOM   2096 C CD1   . ILE   A 1 411  ? 113.217 163.421 146.624 1.00 15.11  ?  411  ILE   C CD1   1 
ATOM   2097 N N     . PRO   A 1 412  ? 108.089 161.821 143.873 1.00 9.36   ?  412  PRO   C N     1 
ATOM   2098 C CA    . PRO   A 1 412  ? 106.644 161.859 143.808 1.00 9.08   ?  412  PRO   C CA    1 
ATOM   2099 C C     . PRO   A 1 412  ? 106.023 162.612 144.971 1.00 9.94   ?  412  PRO   C C     1 
ATOM   2100 O O     . PRO   A 1 412  ? 105.058 163.352 144.783 1.00 12.60  ?  412  PRO   C O     1 
ATOM   2101 C CB    . PRO   A 1 412  ? 106.296 160.374 143.854 1.00 9.26   ?  412  PRO   C CB    1 
ATOM   2102 C CG    . PRO   A 1 412  ? 107.454 159.708 143.183 1.00 8.58   ?  412  PRO   C CG    1 
ATOM   2103 C CD    . PRO   A 1 412  ? 108.652 160.497 143.614 1.00 9.33   ?  412  PRO   C CD    1 
ATOM   2104 N N     . LEU   A 1 413  ? 106.594 162.461 146.163 1.00 9.08   ?  413  LEU   C N     1 
ATOM   2105 C CA    . LEU   A 1 413  ? 106.096 163.177 147.323 1.00 7.71   ?  413  LEU   C CA    1 
ATOM   2106 C C     . LEU   A 1 413  ? 106.248 164.675 147.157 1.00 9.28   ?  413  LEU   C C     1 
ATOM   2107 O O     . LEU   A 1 413  ? 105.379 165.437 147.576 1.00 13.52  ?  413  LEU   C O     1 
ATOM   2108 C CB    . LEU   A 1 413  ? 106.820 162.725 148.590 1.00 10.55  ?  413  LEU   C CB    1 
ATOM   2109 C CG    . LEU   A 1 413  ? 106.405 163.414 149.903 1.00 9.13   ?  413  LEU   C CG    1 
ATOM   2110 C CD1   . LEU   A 1 413  ? 104.929 163.178 150.180 1.00 12.25  ?  413  LEU   C CD1   1 
ATOM   2111 C CD2   . LEU   A 1 413  ? 107.257 162.864 151.033 1.00 10.29  ?  413  LEU   C CD2   1 
ATOM   2112 N N     . VAL   A 1 414  ? 107.351 165.113 146.566 1.00 11.44  ?  414  VAL   C N     1 
ATOM   2113 C CA    . VAL   A 1 414  ? 107.569 166.537 146.394 1.00 11.35  ?  414  VAL   C CA    1 
ATOM   2114 C C     . VAL   A 1 414  ? 106.539 167.075 145.428 1.00 13.91  ?  414  VAL   C C     1 
ATOM   2115 O O     . VAL   A 1 414  ? 105.966 168.141 145.650 1.00 17.18  ?  414  VAL   C O     1 
ATOM   2116 C CB    . VAL   A 1 414  ? 108.992 166.824 145.892 1.00 11.67  ?  414  VAL   C CB    1 
ATOM   2117 C CG1   . VAL   A 1 414  ? 109.147 168.302 145.533 1.00 13.20  ?  414  VAL   C CG1   1 
ATOM   2118 C CG2   . VAL   A 1 414  ? 109.982 166.437 146.972 1.00 13.46  ?  414  VAL   C CG2   1 
ATOM   2119 N N     . CYS   A 1 415  ? 106.287 166.328 144.359 1.00 13.41  ?  415  CYS   C N     1 
ATOM   2120 C CA    . CYS   A 1 415  ? 105.284 166.749 143.398 1.00 13.60  ?  415  CYS   C CA    1 
ATOM   2121 C C     . CYS   A 1 415  ? 103.933 166.894 144.075 1.00 15.20  ?  415  CYS   C C     1 
ATOM   2122 O O     . CYS   A 1 415  ? 103.238 167.892 143.876 1.00 17.67  ?  415  CYS   C O     1 
ATOM   2123 C CB    . CYS   A 1 415  ? 105.140 165.741 142.265 1.00 13.41  ?  415  CYS   C CB    1 
ATOM   2124 S SG    . CYS   A 1 415  ? 106.514 165.662 141.146 1.00 18.35  ?  415  CYS   C SG    1 
ATOM   2125 N N     . TRP   A 1 416  ? 103.571 165.912 144.897 1.00 13.64  ?  416  TRP   C N     1 
ATOM   2126 C CA    . TRP   A 1 416  ? 102.296 165.938 145.593 1.00 13.80  ?  416  TRP   C CA    1 
ATOM   2127 C C     . TRP   A 1 416  ? 102.182 167.155 146.495 1.00 16.85  ?  416  TRP   C C     1 
ATOM   2128 O O     . TRP   A 1 416  ? 101.161 167.848 146.491 1.00 20.70  ?  416  TRP   C O     1 
ATOM   2129 C CB    . TRP   A 1 416  ? 102.096 164.671 146.423 1.00 12.96  ?  416  TRP   C CB    1 
ATOM   2130 C CG    . TRP   A 1 416  ? 100.811 164.681 147.172 1.00 18.23  ?  416  TRP   C CG    1 
ATOM   2131 C CD1   . TRP   A 1 416  ? 99.602  164.254 146.728 1.00 18.96  ?  416  TRP   C CD1   1 
ATOM   2132 C CD2   . TRP   A 1 416  ? 100.594 165.168 148.508 1.00 18.71  ?  416  TRP   C CD2   1 
ATOM   2133 N NE1   . TRP   A 1 416  ? 98.655  164.447 147.691 1.00 18.74  ?  416  TRP   C NE1   1 
ATOM   2134 C CE2   . TRP   A 1 416  ? 99.247  165.007 148.785 1.00 18.75  ?  416  TRP   C CE2   1 
ATOM   2135 C CE3   . TRP   A 1 416  ? 101.422 165.715 149.470 1.00 19.61  ?  416  TRP   C CE3   1 
ATOM   2136 C CZ2   . TRP   A 1 416  ? 98.703  165.395 149.984 1.00 25.27  ?  416  TRP   C CZ2   1 
ATOM   2137 C CZ3   . TRP   A 1 416  ? 100.885 166.104 150.675 1.00 20.00  ?  416  TRP   C CZ3   1 
ATOM   2138 C CH2   . TRP   A 1 416  ? 99.562  165.949 150.927 1.00 25.06  ?  416  TRP   C CH2   1 
ATOM   2139 N N     . ILE   A 1 417  ? 103.234 167.427 147.261 1.00 16.45  ?  417  ILE   C N     1 
ATOM   2140 C CA    . ILE   A 1 417  ? 103.217 168.547 148.188 1.00 17.07  ?  417  ILE   C CA    1 
ATOM   2141 C C     . ILE   A 1 417  ? 103.048 169.857 147.440 1.00 18.51  ?  417  ILE   C C     1 
ATOM   2142 O O     . ILE   A 1 417  ? 102.266 170.720 147.849 1.00 22.36  ?  417  ILE   C O     1 
ATOM   2143 C CB    . ILE   A 1 417  ? 104.510 168.597 149.031 1.00 18.44  ?  417  ILE   C CB    1 
ATOM   2144 C CG1   . ILE   A 1 417  ? 104.580 167.392 149.978 1.00 16.30  ?  417  ILE   C CG1   1 
ATOM   2145 C CG2   . ILE   A 1 417  ? 104.543 169.873 149.829 1.00 21.33  ?  417  ILE   C CG2   1 
ATOM   2146 C CD1   . ILE   A 1 417  ? 105.926 167.203 150.639 1.00 16.51  ?  417  ILE   C CD1   1 
ATOM   2147 N N     . VAL   A 1 418  ? 103.785 170.017 146.349 1.00 18.79  ?  418  VAL   C N     1 
ATOM   2148 C CA    . VAL   A 1 418  ? 103.711 171.239 145.568 1.00 21.18  ?  418  VAL   C CA    1 
ATOM   2149 C C     . VAL   A 1 418  ? 102.348 171.402 144.911 1.00 22.21  ?  418  VAL   C C     1 
ATOM   2150 O O     . VAL   A 1 418  ? 101.782 172.497 144.914 1.00 25.41  ?  418  VAL   C O     1 
ATOM   2151 C CB    . VAL   A 1 418  ? 104.812 171.265 144.498 1.00 22.48  ?  418  VAL   C CB    1 
ATOM   2152 C CG1   . VAL   A 1 418  ? 104.627 172.458 143.584 1.00 25.78  ?  418  VAL   C CG1   1 
ATOM   2153 C CG2   . VAL   A 1 418  ? 106.166 171.336 145.169 1.00 19.71  ?  418  VAL   C CG2   1 
ATOM   2154 N N     . CYS   A 1 419  ? 101.821 170.322 144.342 1.00 21.35  ?  419  CYS   C N     1 
ATOM   2155 C CA    . CYS   A 1 419  ? 100.529 170.379 143.677 1.00 22.67  ?  419  CYS   C CA    1 
ATOM   2156 C C     . CYS   A 1 419  ? 99.429  170.774 144.643 1.00 21.63  ?  419  CYS   C C     1 
ATOM   2157 O O     . CYS   A 1 419  ? 98.576  171.600 144.316 1.00 29.41  ?  419  CYS   C O     1 
ATOM   2158 C CB    . CYS   A 1 419  ? 100.176 169.031 143.068 1.00 21.93  ?  419  CYS   C CB    1 
ATOM   2159 S SG    . CYS   A 1 419  ? 101.164 168.570 141.662 1.00 23.70  ?  419  CYS   C SG    1 
ATOM   2160 N N     . THR   A 1 420  ? 99.454  170.200 145.841 1.00 22.47  ?  420  THR   C N     1 
ATOM   2161 C CA    . THR   A 1 420  ? 98.443  170.506 146.838 1.00 23.83  ?  420  THR   C CA    1 
ATOM   2162 C C     . THR   A 1 420  ? 98.503  171.971 147.223 1.00 24.73  ?  420  THR   C C     1 
ATOM   2163 O O     . THR   A 1 420  ? 97.468  172.630 147.339 1.00 29.53  ?  420  THR   C O     1 
ATOM   2164 C CB    . THR   A 1 420  ? 98.600  169.623 148.085 1.00 23.31  ?  420  THR   C CB    1 
ATOM   2165 O OG1   . THR   A 1 420  ? 98.424  168.249 147.717 1.00 20.12  ?  420  THR   C OG1   1 
ATOM   2166 C CG2   . THR   A 1 420  ? 97.560  170.007 149.139 1.00 32.47  ?  420  THR   C CG2   1 
ATOM   2167 N N     . GLY   A 1 421  ? 99.710  172.487 147.412 1.00 25.36  ?  421  GLY   C N     1 
ATOM   2168 C CA    . GLY   A 1 421  ? 99.880  173.888 147.756 1.00 28.96  ?  421  GLY   C CA    1 
ATOM   2169 C C     . GLY   A 1 421  ? 99.284  174.785 146.679 1.00 30.47  ?  421  GLY   C C     1 
ATOM   2170 O O     . GLY   A 1 421  ? 98.535  175.715 146.984 1.00 33.17  ?  421  GLY   C O     1 
ATOM   2171 N N     . LEU   A 1 422  ? 99.605  174.499 145.419 1.00 30.01  ?  422  LEU   C N     1 
ATOM   2172 C CA    . LEU   A 1 422  ? 99.108  175.309 144.317 1.00 31.15  ?  422  LEU   C CA    1 
ATOM   2173 C C     . LEU   A 1 422  ? 97.593  175.245 144.210 1.00 32.67  ?  422  LEU   C C     1 
ATOM   2174 O O     . LEU   A 1 422  ? 96.945  176.262 143.964 1.00 31.98  ?  422  LEU   C O     1 
ATOM   2175 C CB    . LEU   A 1 422  ? 99.736  174.849 142.999 1.00 29.61  ?  422  LEU   C CB    1 
ATOM   2176 C CG    . LEU   A 1 422  ? 101.236 175.136 142.823 1.00 31.78  ?  422  LEU   C CG    1 
ATOM   2177 C CD1   . LEU   A 1 422  ? 101.728 174.418 141.584 1.00 29.42  ?  422  LEU   C CD1   1 
ATOM   2178 C CD2   . LEU   A 1 422  ? 101.466 176.641 142.692 1.00 33.59  ?  422  LEU   C CD2   1 
ATOM   2179 N N     . LYS   A 1 423  ? 97.021  174.063 144.417 1.00 33.45  ?  423  LYS   C N     1 
ATOM   2180 C CA    . LYS   A 1 423  ? 95.574  173.912 144.365 1.00 33.85  ?  423  LYS   C CA    1 
ATOM   2181 C C     . LYS   A 1 423  ? 94.903  174.814 145.393 1.00 34.83  ?  423  LYS   C C     1 
ATOM   2182 O O     . LYS   A 1 423  ? 93.919  175.489 145.087 1.00 36.88  ?  423  LYS   C O     1 
ATOM   2183 C CB    . LYS   A 1 423  ? 95.178  172.452 144.601 1.00 30.77  ?  423  LYS   C CB    1 
ATOM   2184 C CG    . LYS   A 1 423  ? 93.678  172.165 144.508 1.00 32.11  ?  423  LYS   C CG    1 
ATOM   2185 C CD    . LYS   A 1 423  ? 93.395  170.673 144.712 1.00 43.32  ?  423  LYS   C CD    1 
ATOM   2186 C CE    . LYS   A 1 423  ? 91.926  170.313 144.448 1.00 43.14  ?  423  LYS   C CE    1 
ATOM   2187 N NZ    . LYS   A 1 423  ? 91.003  170.821 145.515 1.00 35.57  1  423  LYS   C NZ    1 
ATOM   2188 N N     . GLN   A 1 424  ? 95.446  174.840 146.608 1.00 33.93  ?  424  GLN   C N     1 
ATOM   2189 C CA    . GLN   A 1 424  ? 94.880  175.671 147.663 1.00 35.45  ?  424  GLN   C CA    1 
ATOM   2190 C C     . GLN   A 1 424  ? 94.990  177.152 147.324 1.00 33.86  ?  424  GLN   C C     1 
ATOM   2191 O O     . GLN   A 1 424  ? 94.059  177.922 147.566 1.00 34.86  ?  424  GLN   C O     1 
ATOM   2192 C CB    . GLN   A 1 424  ? 95.593  175.403 148.989 1.00 35.16  ?  424  GLN   C CB    1 
ATOM   2193 C CG    . GLN   A 1 424  ? 95.352  174.023 149.563 1.00 39.06  ?  424  GLN   C CG    1 
ATOM   2194 C CD    . GLN   A 1 424  ? 93.935  173.833 150.033 1.00 49.37  ?  424  GLN   C CD    1 
ATOM   2195 O OE1   . GLN   A 1 424  ? 93.429  174.606 150.850 1.00 46.95  ?  424  GLN   C OE1   1 
ATOM   2196 N NE2   . GLN   A 1 424  ? 93.278  172.804 149.519 1.00 49.53  ?  424  GLN   C NE2   1 
ATOM   2197 N N     . GLN   A 1 425  ? 96.115  177.546 146.734 1.00 30.82  ?  425  GLN   C N     1 
ATOM   2198 C CA    . GLN   A 1 425  ? 96.309  178.935 146.354 1.00 31.33  ?  425  GLN   C CA    1 
ATOM   2199 C C     . GLN   A 1 425  ? 95.316  179.346 145.273 1.00 0.04   ?  425  GLN   C C     1 
ATOM   2200 O O     . GLN   A 1 425  ? 94.816  180.473 145.273 1.00 50.05  ?  425  GLN   C O     1 
ATOM   2201 C CB    . GLN   A 1 425  ? 97.743  179.164 145.881 1.00 32.48  ?  425  GLN   C CB    1 
ATOM   2202 C CG    . GLN   A 1 425  ? 98.783  179.099 146.970 1.00 39.70  ?  425  GLN   C CG    1 
ATOM   2203 C CD    . GLN   A 1 425  ? 100.179 179.149 146.414 1.00 42.61  ?  425  GLN   C CD    1 
ATOM   2204 O OE1   . GLN   A 1 425  ? 100.564 178.271 145.645 1.00 39.90  ?  425  GLN   C OE1   1 
ATOM   2205 N NE2   . GLN   A 1 425  ? 100.943 180.171 146.780 1.00 42.51  ?  425  GLN   C NE2   1 
ATOM   2206 N N     . MET   A 1 426  ? 95.018  178.428 144.353 1.00 38.37  ?  426  MET   C N     1 
ATOM   2207 C CA    . MET   A 1 426  ? 94.043  178.707 143.303 1.00 36.07  ?  426  MET   C CA    1 
ATOM   2208 C C     . MET   A 1 426  ? 92.672  178.966 143.901 1.00 37.55  ?  426  MET   C C     1 
ATOM   2209 O O     . MET   A 1 426  ? 92.015  179.954 143.571 1.00 41.73  ?  426  MET   C O     1 
ATOM   2210 C CB    . MET   A 1 426  ? 93.987  177.544 142.312 1.00 41.37  ?  426  MET   C CB    1 
ATOM   2211 C CG    . MET   A 1 426  ? 95.232  177.392 141.444 1.00 40.11  ?  426  MET   C CG    1 
ATOM   2212 S SD    . MET   A 1 426  ? 95.184  175.935 140.392 1.00 52.12  ?  426  MET   C SD    1 
ATOM   2213 C CE    . MET   A 1 426  ? 96.882  175.867 139.813 1.00 46.38  ?  426  MET   C CE    1 
ATOM   2214 N N     . GLU   A 1 427  ? 92.253  178.095 144.810 1.00 36.30  ?  427  GLU   C N     1 
ATOM   2215 C CA    . GLU   A 1 427  ? 90.932  178.192 145.417 1.00 40.71  ?  427  GLU   C CA    1 
ATOM   2216 C C     . GLU   A 1 427  ? 90.751  179.494 146.190 1.00 40.26  ?  427  GLU   C C     1 
ATOM   2217 O O     . GLU   A 1 427  ? 89.664  180.074 146.202 1.00 37.26  ?  427  GLU   C O     1 
ATOM   2218 C CB    . GLU   A 1 427  ? 90.701  177.006 146.349 1.00 34.28  ?  427  GLU   C CB    1 
ATOM   2219 C CG    . GLU   A 1 427  ? 90.581  175.670 145.640 1.00 30.19  ?  427  GLU   C CG    1 
ATOM   2220 C CD    . GLU   A 1 427  ? 90.482  174.523 146.596 1.00 34.05  ?  427  GLU   C CD    1 
ATOM   2221 O OE1   . GLU   A 1 427  ? 90.473  174.766 147.778 1.00 34.00  ?  427  GLU   C OE1   1 
ATOM   2222 O OE2   . GLU   A 1 427  ? 90.427  173.400 146.149 1.00 35.69  -1 427  GLU   C OE2   1 
ATOM   2223 N N     . SER   A 1 428  ? 91.822  179.957 146.825 1.00 40.49  ?  428  SER   C N     1 
ATOM   2224 C CA    . SER   A 1 428  ? 91.779  181.166 147.641 1.00 41.31  ?  428  SER   C CA    1 
ATOM   2225 C C     . SER   A 1 428  ? 92.021  182.456 146.852 1.00 40.08  ?  428  SER   C C     1 
ATOM   2226 O O     . SER   A 1 428  ? 92.010  183.543 147.431 1.00 37.73  ?  428  SER   C O     1 
ATOM   2227 C CB    . SER   A 1 428  ? 92.787  181.061 148.769 1.00 43.24  ?  428  SER   C CB    1 
ATOM   2228 O OG    . SER   A 1 428  ? 92.429  180.049 149.672 1.00 47.34  ?  428  SER   C OG    1 
ATOM   2229 N N     . GLY   A 1 429  ? 92.257  182.345 145.543 1.00 40.14  ?  429  GLY   C N     1 
ATOM   2230 C CA    . GLY   A 1 429  ? 92.482  183.528 144.714 1.00 43.13  ?  429  GLY   C CA    1 
ATOM   2231 C C     . GLY   A 1 429  ? 93.852  184.174 144.928 1.00 40.86  ?  429  GLY   C C     1 
ATOM   2232 O O     . GLY   A 1 429  ? 93.990  185.393 144.824 1.00 33.91  ?  429  GLY   C O     1 
ATOM   2233 N N     . LYS   A 1 430  ? 94.859  183.365 145.238 1.00 39.78  ?  430  LYS   C N     1 
ATOM   2234 C CA    . LYS   A 1 430  ? 96.205  183.867 145.492 1.00 38.29  ?  430  LYS   C CA    1 
ATOM   2235 C C     . LYS   A 1 430  ? 97.057  183.884 144.223 1.00 35.61  ?  430  LYS   C C     1 
ATOM   2236 O O     . LYS   A 1 430  ? 96.629  183.425 143.165 1.00 35.98  ?  430  LYS   C O     1 
ATOM   2237 C CB    . LYS   A 1 430  ? 96.884  183.041 146.582 1.00 38.63  ?  430  LYS   C CB    1 
ATOM   2238 C CG    . LYS   A 1 430  ? 96.233  183.165 147.955 1.00 39.47  ?  430  LYS   C CG    1 
ATOM   2239 C CD    . LYS   A 1 430  ? 96.997  182.369 149.007 1.00 37.91  ?  430  LYS   C CD    1 
ATOM   2240 C CE    . LYS   A 1 430  ? 96.330  182.451 150.377 1.00 51.55  ?  430  LYS   C CE    1 
ATOM   2241 N NZ    . LYS   A 1 430  ? 96.449  183.813 150.978 1.00 65.54  1  430  LYS   C NZ    1 
ATOM   2242 N N     . SER   A 1 431  ? 98.266  184.436 144.339 1.00 44.61  ?  431  SER   C N     1 
ATOM   2243 C CA    . SER   A 1 431  ? 99.193  184.583 143.214 1.00 48.00  ?  431  SER   C CA    1 
ATOM   2244 C C     . SER   A 1 431  ? 99.737  183.256 142.695 1.00 42.87  ?  431  SER   C C     1 
ATOM   2245 O O     . SER   A 1 431  ? 100.302 183.194 141.602 1.00 49.51  ?  431  SER   C O     1 
ATOM   2246 C CB    . SER   A 1 431  ? 100.364 185.448 143.625 1.00 50.15  ?  431  SER   C CB    1 
ATOM   2247 O OG    . SER   A 1 431  ? 101.175 184.774 144.554 1.00 50.78  ?  431  SER   C OG    1 
ATOM   2248 N N     . LEU   A 1 432  ? 99.581  182.206 143.490 1.00 37.50  ?  432  LEU   C N     1 
ATOM   2249 C CA    . LEU   A 1 432  ? 100.045 180.863 143.153 1.00 35.21  ?  432  LEU   C CA    1 
ATOM   2250 C C     . LEU   A 1 432  ? 101.559 180.751 143.152 1.00 39.61  ?  432  LEU   C C     1 
ATOM   2251 O O     . LEU   A 1 432  ? 102.101 179.768 142.657 1.00 39.89  ?  432  LEU   C O     1 
ATOM   2252 C CB    . LEU   A 1 432  ? 99.556  180.439 141.754 1.00 31.60  ?  432  LEU   C CB    1 
ATOM   2253 C CG    . LEU   A 1 432  ? 98.084  180.697 141.418 1.00 36.49  ?  432  LEU   C CG    1 
ATOM   2254 C CD1   . LEU   A 1 432  ? 97.770  180.114 140.048 1.00 41.19  ?  432  LEU   C CD1   1 
ATOM   2255 C CD2   . LEU   A 1 432  ? 97.229  180.101 142.468 1.00 41.60  ?  432  LEU   C CD2   1 
ATOM   2256 N N     . ALA   A 1 433  ? 102.248 181.740 143.710 1.00 41.31  ?  433  ALA   C N     1 
ATOM   2257 C CA    . ALA   A 1 433  ? 103.706 181.733 143.709 1.00 34.17  ?  433  ALA   C CA    1 
ATOM   2258 C C     . ALA   A 1 433  ? 104.269 180.550 144.482 1.00 41.44  ?  433  ALA   C C     1 
ATOM   2259 O O     . ALA   A 1 433  ? 103.765 180.182 145.545 1.00 40.20  ?  433  ALA   C O     1 
ATOM   2260 C CB    . ALA   A 1 433  ? 104.236 183.026 144.301 1.00 34.90  ?  433  ALA   C CB    1 
ATOM   2261 N N     . GLN   A 1 434  ? 105.341 179.975 143.939 1.00 39.59  ?  434  GLN   C N     1 
ATOM   2262 C CA    . GLN   A 1 434  ? 106.073 178.877 144.559 1.00 35.73  ?  434  GLN   C CA    1 
ATOM   2263 C C     . GLN   A 1 434  ? 107.568 179.043 144.328 1.00 33.05  ?  434  GLN   C C     1 
ATOM   2264 O O     . GLN   A 1 434  ? 108.091 178.683 143.270 1.00 33.91  ?  434  GLN   C O     1 
ATOM   2265 C CB    . GLN   A 1 434  ? 105.578 177.534 144.021 1.00 36.09  ?  434  GLN   C CB    1 
ATOM   2266 C CG    . GLN   A 1 434  ? 106.413 176.337 144.436 1.00 33.13  ?  434  GLN   C CG    1 
ATOM   2267 C CD    . GLN   A 1 434  ? 106.581 176.188 145.935 1.00 34.23  ?  434  GLN   C CD    1 
ATOM   2268 O OE1   . GLN   A 1 434  ? 107.406 176.882 146.549 1.00 35.02  ?  434  GLN   C OE1   1 
ATOM   2269 N NE2   . GLN   A 1 434  ? 105.820 175.283 146.533 1.00 32.21  ?  434  GLN   C NE2   1 
ATOM   2270 N N     . THR   A 1 435  ? 108.242 179.622 145.313 1.00 31.39  ?  435  THR   C N     1 
ATOM   2271 C CA    . THR   A 1 435  ? 109.639 180.005 145.180 1.00 34.23  ?  435  THR   C CA    1 
ATOM   2272 C C     . THR   A 1 435  ? 110.556 179.213 146.103 1.00 31.62  ?  435  THR   C C     1 
ATOM   2273 O O     . THR   A 1 435  ? 111.673 179.642 146.392 1.00 32.24  ?  435  THR   C O     1 
ATOM   2274 C CB    . THR   A 1 435  ? 109.803 181.507 145.463 1.00 39.12  ?  435  THR   C CB    1 
ATOM   2275 O OG1   . THR   A 1 435  ? 109.358 181.796 146.797 1.00 36.49  ?  435  THR   C OG1   1 
ATOM   2276 C CG2   . THR   A 1 435  ? 108.966 182.310 144.476 1.00 33.49  ?  435  THR   C CG2   1 
ATOM   2277 N N     . SER   A 1 436  ? 110.079 178.072 146.585 1.00 30.88  ?  436  SER   C N     1 
ATOM   2278 C CA    . SER   A 1 436  ? 110.870 177.245 147.490 1.00 27.42  ?  436  SER   C CA    1 
ATOM   2279 C C     . SER   A 1 436  ? 112.148 176.747 146.820 1.00 29.03  ?  436  SER   C C     1 
ATOM   2280 O O     . SER   A 1 436  ? 112.154 176.418 145.633 1.00 28.32  ?  436  SER   C O     1 
ATOM   2281 C CB    . SER   A 1 436  ? 110.052 176.061 147.961 1.00 27.26  ?  436  SER   C CB    1 
ATOM   2282 O OG    . SER   A 1 436  ? 108.927 176.480 148.685 1.00 29.49  ?  436  SER   C OG    1 
ATOM   2283 N N     . LYS   A 1 437  ? 113.239 176.701 147.585 1.00 27.80  ?  437  LYS   C N     1 
ATOM   2284 C CA    . LYS   A 1 437  ? 114.520 176.219 147.076 1.00 23.28  ?  437  LYS   C CA    1 
ATOM   2285 C C     . LYS   A 1 437  ? 114.998 174.951 147.775 1.00 22.78  ?  437  LYS   C C     1 
ATOM   2286 O O     . LYS   A 1 437  ? 115.818 174.206 147.243 1.00 23.26  ?  437  LYS   C O     1 
ATOM   2287 C CB    . LYS   A 1 437  ? 115.586 177.301 147.215 1.00 26.12  ?  437  LYS   C CB    1 
ATOM   2288 C CG    . LYS   A 1 437  ? 115.344 178.533 146.368 1.00 33.09  ?  437  LYS   C CG    1 
ATOM   2289 C CD    . LYS   A 1 437  ? 116.469 179.545 146.537 1.00 45.97  ?  437  LYS   C CD    1 
ATOM   2290 C CE    . LYS   A 1 437  ? 116.229 180.789 145.696 1.00 44.09  ?  437  LYS   C CE    1 
ATOM   2291 N NZ    . LYS   A 1 437  ? 117.307 181.800 145.885 1.00 48.77  1  437  LYS   C NZ    1 
ATOM   2292 N N     . THR   A 1 438  ? 114.527 174.730 148.990 1.00 21.64  ?  438  THR   C N     1 
ATOM   2293 C CA    . THR   A 1 438  ? 115.006 173.615 149.791 1.00 18.06  ?  438  THR   C CA    1 
ATOM   2294 C C     . THR   A 1 438  ? 113.851 172.729 150.206 1.00 17.16  ?  438  THR   C C     1 
ATOM   2295 O O     . THR   A 1 438  ? 112.691 173.108 150.045 1.00 19.25  ?  438  THR   C O     1 
ATOM   2296 C CB    . THR   A 1 438  ? 115.758 174.123 151.033 1.00 18.95  ?  438  THR   C CB    1 
ATOM   2297 O OG1   . THR   A 1 438  ? 114.850 174.819 151.901 1.00 21.32  ?  438  THR   C OG1   1 
ATOM   2298 C CG2   . THR   A 1 438  ? 116.879 175.067 150.617 1.00 19.79  ?  438  THR   C CG2   1 
ATOM   2299 N N     . THR   A 1 439  ? 114.155 171.548 150.734 1.00 18.23  ?  439  THR   C N     1 
ATOM   2300 C CA    . THR   A 1 439  ? 113.103 170.647 151.175 1.00 14.75  ?  439  THR   C CA    1 
ATOM   2301 C C     . THR   A 1 439  ? 112.327 171.291 152.306 1.00 15.25  ?  439  THR   C C     1 
ATOM   2302 O O     . THR   A 1 439  ? 111.099 171.221 152.348 1.00 18.05  ?  439  THR   C O     1 
ATOM   2303 C CB    . THR   A 1 439  ? 113.659 169.284 151.625 1.00 16.73  ?  439  THR   C CB    1 
ATOM   2304 O OG1   . THR   A 1 439  ? 114.314 168.645 150.523 1.00 21.14  ?  439  THR   C OG1   1 
ATOM   2305 C CG2   . THR   A 1 439  ? 112.528 168.389 152.115 1.00 18.90  ?  439  THR   C CG2   1 
ATOM   2306 N N     . THR   A 1 440  ? 113.047 171.933 153.218 1.00 17.53  ?  440  THR   C N     1 
ATOM   2307 C CA    . THR   A 1 440  ? 112.405 172.606 154.334 1.00 17.19  ?  440  THR   C CA    1 
ATOM   2308 C C     . THR   A 1 440  ? 111.485 173.692 153.819 1.00 18.37  ?  440  THR   C C     1 
ATOM   2309 O O     . THR   A 1 440  ? 110.336 173.792 154.249 1.00 21.19  ?  440  THR   C O     1 
ATOM   2310 C CB    . THR   A 1 440  ? 113.441 173.216 155.294 1.00 17.43  ?  440  THR   C CB    1 
ATOM   2311 O OG1   . THR   A 1 440  ? 114.269 172.176 155.818 1.00 19.32  ?  440  THR   C OG1   1 
ATOM   2312 C CG2   . THR   A 1 440  ? 112.736 173.916 156.453 1.00 19.87  ?  440  THR   C CG2   1 
ATOM   2313 N N     . ALA   A 1 441  ? 111.954 174.487 152.867 1.00 19.06  ?  441  ALA   C N     1 
ATOM   2314 C CA    . ALA   A 1 441  ? 111.132 175.557 152.330 1.00 18.44  ?  441  ALA   C CA    1 
ATOM   2315 C C     . ALA   A 1 441  ? 109.827 175.010 151.764 1.00 19.87  ?  441  ALA   C C     1 
ATOM   2316 O O     . ALA   A 1 441  ? 108.772 175.614 151.933 1.00 24.04  ?  441  ALA   C O     1 
ATOM   2317 C CB    . ALA   A 1 441  ? 111.883 176.316 151.253 1.00 23.46  ?  441  ALA   C CB    1 
ATOM   2318 N N     . VAL   A 1 442  ? 109.904 173.852 151.113 1.00 19.42  ?  442  VAL   C N     1 
ATOM   2319 C CA    . VAL   A 1 442  ? 108.707 173.242 150.550 1.00 16.57  ?  442  VAL   C CA    1 
ATOM   2320 C C     . VAL   A 1 442  ? 107.734 172.834 151.650 1.00 18.78  ?  442  VAL   C C     1 
ATOM   2321 O O     . VAL   A 1 442  ? 106.532 173.092 151.545 1.00 22.04  ?  442  VAL   C O     1 
ATOM   2322 C CB    . VAL   A 1 442  ? 109.080 172.013 149.690 1.00 15.08  ?  442  VAL   C CB    1 
ATOM   2323 C CG1   . VAL   A 1 442  ? 107.833 171.250 149.295 1.00 18.06  ?  442  VAL   C CG1   1 
ATOM   2324 C CG2   . VAL   A 1 442  ? 109.816 172.472 148.442 1.00 17.58  ?  442  VAL   C CG2   1 
ATOM   2325 N N     . TYR   A 1 443  ? 108.243 172.210 152.708 1.00 18.09  ?  443  TYR   C N     1 
ATOM   2326 C CA    . TYR   A 1 443  ? 107.392 171.780 153.811 1.00 16.26  ?  443  TYR   C CA    1 
ATOM   2327 C C     . TYR   A 1 443  ? 106.795 172.955 154.573 1.00 21.16  ?  443  TYR   C C     1 
ATOM   2328 O O     . TYR   A 1 443  ? 105.620 172.924 154.938 1.00 26.55  ?  443  TYR   C O     1 
ATOM   2329 C CB    . TYR   A 1 443  ? 108.162 170.863 154.758 1.00 13.91  ?  443  TYR   C CB    1 
ATOM   2330 C CG    . TYR   A 1 443  ? 108.201 169.429 154.291 1.00 13.29  ?  443  TYR   C CG    1 
ATOM   2331 C CD1   . TYR   A 1 443  ? 108.710 169.119 153.048 1.00 13.26  ?  443  TYR   C CD1   1 
ATOM   2332 C CD2   . TYR   A 1 443  ? 107.723 168.421 155.108 1.00 12.83  ?  443  TYR   C CD2   1 
ATOM   2333 C CE1   . TYR   A 1 443  ? 108.735 167.822 152.620 1.00 14.73  ?  443  TYR   C CE1   1 
ATOM   2334 C CE2   . TYR   A 1 443  ? 107.752 167.115 154.671 1.00 12.74  ?  443  TYR   C CE2   1 
ATOM   2335 C CZ    . TYR   A 1 443  ? 108.255 166.820 153.431 1.00 12.39  ?  443  TYR   C CZ    1 
ATOM   2336 O OH    . TYR   A 1 443  ? 108.280 165.525 152.985 1.00 15.34  ?  443  TYR   C OH    1 
ATOM   2337 N N     . VAL   A 1 444  ? 107.583 174.003 154.785 1.00 21.41  ?  444  VAL   C N     1 
ATOM   2338 C CA    . VAL   A 1 444  ? 107.078 175.176 155.481 1.00 23.93  ?  444  VAL   C CA    1 
ATOM   2339 C C     . VAL   A 1 444  ? 105.997 175.845 154.650 1.00 26.82  ?  444  VAL   C C     1 
ATOM   2340 O O     . VAL   A 1 444  ? 104.956 176.234 155.178 1.00 33.91  ?  444  VAL   C O     1 
ATOM   2341 C CB    . VAL   A 1 444  ? 108.213 176.175 155.785 1.00 23.30  ?  444  VAL   C CB    1 
ATOM   2342 C CG1   . VAL   A 1 444  ? 107.641 177.489 156.327 1.00 30.96  ?  444  VAL   C CG1   1 
ATOM   2343 C CG2   . VAL   A 1 444  ? 109.155 175.566 156.810 1.00 21.82  ?  444  VAL   C CG2   1 
ATOM   2344 N N     . PHE   A 1 445  ? 106.238 175.970 153.351 1.00 26.33  ?  445  PHE   C N     1 
ATOM   2345 C CA    . PHE   A 1 445  ? 105.270 176.551 152.433 1.00 29.70  ?  445  PHE   C CA    1 
ATOM   2346 C C     . PHE   A 1 445  ? 103.949 175.804 152.492 1.00 31.46  ?  445  PHE   C C     1 
ATOM   2347 O O     . PHE   A 1 445  ? 102.890 176.406 152.663 1.00 38.53  ?  445  PHE   C O     1 
ATOM   2348 C CB    . PHE   A 1 445  ? 105.823 176.500 151.013 1.00 31.43  ?  445  PHE   C CB    1 
ATOM   2349 C CG    . PHE   A 1 445  ? 104.885 176.939 149.943 1.00 35.75  ?  445  PHE   C CG    1 
ATOM   2350 C CD1   . PHE   A 1 445  ? 104.804 178.266 149.579 1.00 32.89  ?  445  PHE   C CD1   1 
ATOM   2351 C CD2   . PHE   A 1 445  ? 104.089 176.017 149.283 1.00 36.64  ?  445  PHE   C CD2   1 
ATOM   2352 C CE1   . PHE   A 1 445  ? 103.954 178.661 148.576 1.00 38.47  ?  445  PHE   C CE1   1 
ATOM   2353 C CE2   . PHE   A 1 445  ? 103.238 176.414 148.282 1.00 36.67  ?  445  PHE   C CE2   1 
ATOM   2354 C CZ    . PHE   A 1 445  ? 103.176 177.734 147.929 1.00 42.03  ?  445  PHE   C CZ    1 
ATOM   2355 N N     . PHE   A 1 446  ? 104.021 174.484 152.372 1.00 29.85  ?  446  PHE   C N     1 
ATOM   2356 C CA    . PHE   A 1 446  ? 102.843 173.634 152.396 1.00 28.95  ?  446  PHE   C CA    1 
ATOM   2357 C C     . PHE   A 1 446  ? 102.045 173.815 153.671 1.00 32.93  ?  446  PHE   C C     1 
ATOM   2358 O O     . PHE   A 1 446  ? 100.841 174.067 153.631 1.00 40.78  ?  446  PHE   C O     1 
ATOM   2359 C CB    . PHE   A 1 446  ? 103.286 172.184 152.273 1.00 27.33  ?  446  PHE   C CB    1 
ATOM   2360 C CG    . PHE   A 1 446  ? 102.222 171.135 152.447 1.00 26.61  ?  446  PHE   C CG    1 
ATOM   2361 C CD1   . PHE   A 1 446  ? 101.388 170.768 151.404 1.00 25.48  ?  446  PHE   C CD1   1 
ATOM   2362 C CD2   . PHE   A 1 446  ? 102.083 170.488 153.656 1.00 27.45  ?  446  PHE   C CD2   1 
ATOM   2363 C CE1   . PHE   A 1 446  ? 100.451 169.776 151.577 1.00 24.52  ?  446  PHE   C CE1   1 
ATOM   2364 C CE2   . PHE   A 1 446  ? 101.147 169.499 153.831 1.00 27.60  ?  446  PHE   C CE2   1 
ATOM   2365 C CZ    . PHE   A 1 446  ? 100.334 169.139 152.792 1.00 27.26  ?  446  PHE   C CZ    1 
ATOM   2366 N N     . LEU   A 1 447  ? 102.713 173.692 154.808 1.00 31.76  ?  447  LEU   C N     1 
ATOM   2367 C CA    . LEU   A 1 447  ? 102.013 173.774 156.075 1.00 37.62  ?  447  LEU   C CA    1 
ATOM   2368 C C     . LEU   A 1 447  ? 101.489 175.173 156.326 1.00 40.07  ?  447  LEU   C C     1 
ATOM   2369 O O     . LEU   A 1 447  ? 100.384 175.339 156.839 1.00 45.49  ?  447  LEU   C O     1 
ATOM   2370 C CB    . LEU   A 1 447  ? 102.941 173.345 157.209 1.00 32.82  ?  447  LEU   C CB    1 
ATOM   2371 C CG    . LEU   A 1 447  ? 103.362 171.865 157.193 1.00 33.31  ?  447  LEU   C CG    1 
ATOM   2372 C CD1   . LEU   A 1 447  ? 104.432 171.653 158.227 1.00 31.82  ?  447  LEU   C CD1   1 
ATOM   2373 C CD2   . LEU   A 1 447  ? 102.152 170.975 157.464 1.00 34.70  ?  447  LEU   C CD2   1 
ATOM   2374 N N     . SER   A 1 448  ? 102.257 176.181 155.939 1.00 37.28  ?  448  SER   C N     1 
ATOM   2375 C CA    . SER   A 1 448  ? 101.826 177.553 156.128 1.00 45.32  ?  448  SER   C CA    1 
ATOM   2376 C C     . SER   A 1 448  ? 100.555 177.830 155.348 1.00 51.07  ?  448  SER   C C     1 
ATOM   2377 O O     . SER   A 1 448  ? 99.592  178.379 155.887 1.00 56.02  ?  448  SER   C O     1 
ATOM   2378 C CB    . SER   A 1 448  ? 102.916 178.503 155.690 1.00 47.22  ?  448  SER   C CB    1 
ATOM   2379 O OG    . SER   A 1 448  ? 102.497 179.830 155.803 1.00 61.56  ?  448  SER   C OG    1 
ATOM   2380 N N     . SER   A 1 449  ? 100.530 177.416 154.085 1.00 45.79  ?  449  SER   C N     1 
ATOM   2381 C CA    . SER   A 1 449  ? 99.371  177.653 153.239 1.00 51.10  ?  449  SER   C CA    1 
ATOM   2382 C C     . SER   A 1 449  ? 98.123  177.002 153.806 1.00 51.45  ?  449  SER   C C     1 
ATOM   2383 O O     . SER   A 1 449  ? 97.028  177.554 153.697 1.00 57.86  ?  449  SER   C O     1 
ATOM   2384 C CB    . SER   A 1 449  ? 99.622  177.128 151.839 1.00 46.59  ?  449  SER   C CB    1 
ATOM   2385 O OG    . SER   A 1 449  ? 100.613 177.874 151.187 1.00 44.76  ?  449  SER   C OG    1 
ATOM   2386 N N     . LEU   A 1 450  ? 98.282  175.831 154.415 1.00 52.25  ?  450  LEU   C N     1 
ATOM   2387 C CA    . LEU   A 1 450  ? 97.148  175.131 154.997 1.00 54.88  ?  450  LEU   C CA    1 
ATOM   2388 C C     . LEU   A 1 450  ? 96.693  175.754 156.317 1.00 56.27  ?  450  LEU   C C     1 
ATOM   2389 O O     . LEU   A 1 450  ? 95.495  175.817 156.595 1.00 57.80  ?  450  LEU   C O     1 
ATOM   2390 C CB    . LEU   A 1 450  ? 97.501  173.659 155.220 1.00 49.81  ?  450  LEU   C CB    1 
ATOM   2391 C CG    . LEU   A 1 450  ? 97.760  172.806 153.950 1.00 51.53  ?  450  LEU   C CG    1 
ATOM   2392 C CD1   . LEU   A 1 450  ? 98.254  171.438 154.379 1.00 49.99  ?  450  LEU   C CD1   1 
ATOM   2393 C CD2   . LEU   A 1 450  ? 96.479  172.687 153.109 1.00 60.85  ?  450  LEU   C CD2   1 
ATOM   2394 N N     . LEU   A 1 451  ? 97.640  176.232 157.121 1.00 58.09  ?  451  LEU   C N     1 
ATOM   2395 C CA    . LEU   A 1 451  ? 97.297  176.823 158.412 1.00 57.37  ?  451  LEU   C CA    1 
ATOM   2396 C C     . LEU   A 1 451  ? 96.733  178.238 158.293 1.00 74.85  ?  451  LEU   C C     1 
ATOM   2397 O O     . LEU   A 1 451  ? 95.891  178.639 159.096 1.00 65.41  ?  451  LEU   C O     1 
ATOM   2398 C CB    . LEU   A 1 451  ? 98.525  176.829 159.344 1.00 53.23  ?  451  LEU   C CB    1 
ATOM   2399 C CG    . LEU   A 1 451  ? 98.681  175.618 160.324 1.00 55.53  ?  451  LEU   C CG    1 
ATOM   2400 C CD1   . LEU   A 1 451  ? 97.497  175.578 161.303 1.00 62.04  ?  451  LEU   C CD1   1 
ATOM   2401 C CD2   . LEU   A 1 451  ? 98.777  174.326 159.530 1.00 52.82  ?  451  LEU   C CD2   1 
ATOM   2402 N N     . GLN   A 1 452  ? 97.187  179.005 157.310 1.00 63.05  ?  452  GLN   C N     1 
ATOM   2403 C CA    . GLN   A 1 452  ? 96.708  180.376 157.143 1.00 68.21  ?  452  GLN   C CA    1 
ATOM   2404 C C     . GLN   A 1 452  ? 95.159  180.529 157.162 1.00 67.21  ?  452  GLN   C C     1 
ATOM   2405 O O     . GLN   A 1 452  ? 94.664  181.376 157.904 1.00 62.00  ?  452  GLN   C O     1 
ATOM   2406 C CB    . GLN   A 1 452  ? 97.322  181.020 155.893 1.00 67.57  ?  452  GLN   C CB    1 
ATOM   2407 C CG    . GLN   A 1 452  ? 98.768  181.457 156.053 1.00 72.13  ?  452  GLN   C CG    1 
ATOM   2408 C CD    . GLN   A 1 452  ? 99.384  181.920 154.738 1.00 77.69  ?  452  GLN   C CD    1 
ATOM   2409 O OE1   . GLN   A 1 452  ? 98.743  182.648 153.971 1.00 80.67  ?  452  GLN   C OE1   1 
ATOM   2410 N NE2   . GLN   A 1 452  ? 100.616 181.501 154.469 1.00 70.04  ?  452  GLN   C NE2   1 
ATOM   2411 N N     . PRO   A 1 453  ? 94.364  179.755 156.355 1.00 67.12  ?  453  PRO   C N     1 
ATOM   2412 C CA    . PRO   A 1 453  ? 92.908  179.738 156.385 1.00 69.94  ?  453  PRO   C CA    1 
ATOM   2413 C C     . PRO   A 1 453  ? 92.393  178.786 157.462 1.00 68.58  ?  453  PRO   C C     1 
ATOM   2414 O O     . PRO   A 1 453  ? 91.187  178.565 157.597 1.00 58.69  ?  453  PRO   C O     1 
ATOM   2415 C CB    . PRO   A 1 453  ? 92.558  179.249 154.969 1.00 75.39  ?  453  PRO   C CB    1 
ATOM   2416 C CG    . PRO   A 1 453  ? 93.716  178.325 154.577 1.00 69.90  ?  453  PRO   C CG    1 
ATOM   2417 C CD    . PRO   A 1 453  ? 94.947  178.920 155.263 1.00 67.30  ?  453  PRO   C CD    1 
ATOM   2418 N N     . LEU   A 1 462  ? 93.540  177.892 165.691 1.00 75.69  ?  462  LEU   C N     1 
ATOM   2419 C CA    . LEU   A 1 462  ? 93.951  177.110 164.527 1.00 78.68  ?  462  LEU   C CA    1 
ATOM   2420 C C     . LEU   A 1 462  ? 95.475  176.934 164.505 1.00 72.79  ?  462  LEU   C C     1 
ATOM   2421 O O     . LEU   A 1 462  ? 95.978  175.807 164.494 1.00 69.38  ?  462  LEU   C O     1 
ATOM   2422 C CB    . LEU   A 1 462  ? 93.447  177.784 163.220 1.00 79.87  ?  462  LEU   C CB    1 
ATOM   2423 C CG    . LEU   A 1 462  ? 93.823  177.078 161.840 1.00 68.67  ?  462  LEU   C CG    1 
ATOM   2424 C CD1   . LEU   A 1 462  ? 93.203  175.654 161.781 1.00 71.76  ?  462  LEU   C CD1   1 
ATOM   2425 C CD2   . LEU   A 1 462  ? 93.328  177.947 160.660 1.00 61.19  ?  462  LEU   C CD2   1 
ATOM   2426 N N     . CYS   A 1 463  ? 96.206  178.058 164.515 1.00 72.02  ?  463  CYS   C N     1 
ATOM   2427 C CA    . CYS   A 1 463  ? 97.671  178.077 164.488 1.00 71.97  ?  463  CYS   C CA    1 
ATOM   2428 C C     . CYS   A 1 463  ? 98.243  178.022 165.898 1.00 69.63  ?  463  CYS   C C     1 
ATOM   2429 O O     . CYS   A 1 463  ? 99.456  177.954 166.088 1.00 67.20  ?  463  CYS   C O     1 
ATOM   2430 C CB    . CYS   A 1 463  ? 98.165  179.338 163.785 1.00 76.02  ?  463  CYS   C CB    1 
ATOM   2431 S SG    . CYS   A 1 463  ? 97.670  179.447 162.042 1.00 66.33  ?  463  CYS   C SG    1 
ATOM   2432 N N     . ALA   A 1 464  ? 97.352  178.038 166.884 1.00 69.29  ?  464  ALA   C N     1 
ATOM   2433 C CA    . ALA   A 1 464  ? 97.721  178.023 168.294 1.00 67.76  ?  464  ALA   C CA    1 
ATOM   2434 C C     . ALA   A 1 464  ? 97.973  176.601 168.784 1.00 68.46  ?  464  ALA   C C     1 
ATOM   2435 O O     . ALA   A 1 464  ? 98.316  176.385 169.945 1.00 62.39  ?  464  ALA   C O     1 
ATOM   2436 C CB    . ALA   A 1 464  ? 96.624  178.668 169.122 1.00 61.26  ?  464  ALA   C CB    1 
ATOM   2437 N N     . HIS   A 1 465  ? 97.787  175.633 167.898 1.00 62.22  ?  465  HIS   C N     1 
ATOM   2438 C CA    . HIS   A 1 465  ? 97.923  174.230 168.253 1.00 60.08  ?  465  HIS   C CA    1 
ATOM   2439 C C     . HIS   A 1 465  ? 99.255  173.657 167.786 1.00 55.27  ?  465  HIS   C C     1 
ATOM   2440 O O     . HIS   A 1 465  ? 99.478  172.448 167.852 1.00 48.46  ?  465  HIS   C O     1 
ATOM   2441 C CB    . HIS   A 1 465  ? 96.773  173.436 167.639 1.00 65.44  ?  465  HIS   C CB    1 
ATOM   2442 C CG    . HIS   A 1 465  ? 95.439  173.878 168.125 1.00 69.94  ?  465  HIS   C CG    1 
ATOM   2443 N ND1   . HIS   A 1 465  ? 94.926  173.502 169.348 1.00 71.35  ?  465  HIS   C ND1   1 
ATOM   2444 C CD2   . HIS   A 1 465  ? 94.514  174.678 167.557 1.00 71.16  ?  465  HIS   C CD2   1 
ATOM   2445 C CE1   . HIS   A 1 465  ? 93.736  174.051 169.507 1.00 73.59  ?  465  HIS   C CE1   1 
ATOM   2446 N NE2   . HIS   A 1 465  ? 93.463  174.771 168.434 1.00 74.42  ?  465  HIS   C NE2   1 
ATOM   2447 N N     . LEU   A 1 466  ? 100.143 174.531 167.323 1.00 54.12  ?  466  LEU   C N     1 
ATOM   2448 C CA    . LEU   A 1 466  ? 101.430 174.096 166.798 1.00 47.18  ?  466  LEU   C CA    1 
ATOM   2449 C C     . LEU   A 1 466  ? 102.253 173.372 167.852 1.00 41.85  ?  466  LEU   C C     1 
ATOM   2450 O O     . LEU   A 1 466  ? 102.957 172.411 167.541 1.00 41.33  ?  466  LEU   C O     1 
ATOM   2451 C CB    . LEU   A 1 466  ? 102.224 175.299 166.265 1.00 49.54  ?  466  LEU   C CB    1 
ATOM   2452 C CG    . LEU   A 1 466  ? 103.598 174.985 165.606 1.00 47.26  ?  466  LEU   C CG    1 
ATOM   2453 C CD1   . LEU   A 1 466  ? 103.402 174.064 164.395 1.00 48.07  ?  466  LEU   C CD1   1 
ATOM   2454 C CD2   . LEU   A 1 466  ? 104.262 176.293 165.181 1.00 55.43  ?  466  LEU   C CD2   1 
ATOM   2455 N N     . TRP   A 1 467  ? 102.196 173.847 169.093 1.00 43.99  ?  467  TRP   C N     1 
ATOM   2456 C CA    . TRP   A 1 467  ? 102.975 173.233 170.159 1.00 42.19  ?  467  TRP   C CA    1 
ATOM   2457 C C     . TRP   A 1 467  ? 102.583 171.783 170.363 1.00 39.84  ?  467  TRP   C C     1 
ATOM   2458 O O     . TRP   A 1 467  ? 103.433 170.893 170.380 1.00 37.20  ?  467  TRP   C O     1 
ATOM   2459 C CB    . TRP   A 1 467  ? 102.800 173.987 171.475 1.00 45.17  ?  467  TRP   C CB    1 
ATOM   2460 C CG    . TRP   A 1 467  ? 103.505 173.325 172.624 1.00 47.36  ?  467  TRP   C CG    1 
ATOM   2461 C CD1   . TRP   A 1 467  ? 102.959 172.454 173.517 1.00 49.33  ?  467  TRP   C CD1   1 
ATOM   2462 C CD2   . TRP   A 1 467  ? 104.894 173.471 173.009 1.00 47.16  ?  467  TRP   C CD2   1 
ATOM   2463 N NE1   . TRP   A 1 467  ? 103.905 172.046 174.421 1.00 51.49  ?  467  TRP   C NE1   1 
ATOM   2464 C CE2   . TRP   A 1 467  ? 105.094 172.658 174.126 1.00 46.87  ?  467  TRP   C CE2   1 
ATOM   2465 C CE3   . TRP   A 1 467  ? 105.964 174.215 172.507 1.00 48.36  ?  467  TRP   C CE3   1 
ATOM   2466 C CZ2   . TRP   A 1 467  ? 106.327 172.558 174.748 1.00 47.02  ?  467  TRP   C CZ2   1 
ATOM   2467 C CZ3   . TRP   A 1 467  ? 107.201 174.115 173.134 1.00 48.20  ?  467  TRP   C CZ3   1 
ATOM   2468 C CH2   . TRP   A 1 467  ? 107.375 173.308 174.224 1.00 47.57  ?  467  TRP   C CH2   1 
ATOM   2469 N N     . GLY   A 1 468  ? 101.289 171.544 170.534 1.00 43.13  ?  468  GLY   C N     1 
ATOM   2470 C CA    . GLY   A 1 468  ? 100.805 170.195 170.779 1.00 43.12  ?  468  GLY   C CA    1 
ATOM   2471 C C     . GLY   A 1 468  ? 101.113 169.291 169.603 1.00 38.29  ?  468  GLY   C C     1 
ATOM   2472 O O     . GLY   A 1 468  ? 101.465 168.123 169.776 1.00 36.43  ?  468  GLY   C O     1 
ATOM   2473 N N     . LEU   A 1 469  ? 100.987 169.839 168.401 1.00 38.78  ?  469  LEU   C N     1 
ATOM   2474 C CA    . LEU   A 1 469  ? 101.216 169.083 167.185 1.00 36.40  ?  469  LEU   C CA    1 
ATOM   2475 C C     . LEU   A 1 469  ? 102.668 168.641 167.079 1.00 31.79  ?  469  LEU   C C     1 
ATOM   2476 O O     . LEU   A 1 469  ? 102.958 167.481 166.780 1.00 31.34  ?  469  LEU   C O     1 
ATOM   2477 C CB    . LEU   A 1 469  ? 100.829 169.954 165.983 1.00 37.95  ?  469  LEU   C CB    1 
ATOM   2478 C CG    . LEU   A 1 469  ? 101.010 169.360 164.592 1.00 33.56  ?  469  LEU   C CG    1 
ATOM   2479 C CD1   . LEU   A 1 469  ? 100.172 168.116 164.460 1.00 33.71  ?  469  LEU   C CD1   1 
ATOM   2480 C CD2   . LEU   A 1 469  ? 100.590 170.398 163.568 1.00 35.81  ?  469  LEU   C CD2   1 
ATOM   2481 N N     . CYS   A 1 470  ? 103.577 169.570 167.349 1.00 32.99  ?  470  CYS   C N     1 
ATOM   2482 C CA    . CYS   A 1 470  ? 104.997 169.280 167.294 1.00 29.73  ?  470  CYS   C CA    1 
ATOM   2483 C C     . CYS   A 1 470  ? 105.413 168.340 168.412 1.00 28.76  ?  470  CYS   C C     1 
ATOM   2484 O O     . CYS   A 1 470  ? 106.225 167.437 168.205 1.00 27.71  ?  470  CYS   C O     1 
ATOM   2485 C CB    . CYS   A 1 470  ? 105.791 170.568 167.389 1.00 29.27  ?  470  CYS   C CB    1 
ATOM   2486 S SG    . CYS   A 1 470  ? 105.588 171.644 165.966 1.00 32.37  ?  470  CYS   C SG    1 
ATOM   2487 N N     . SER   A 1 471  ? 104.846 168.544 169.595 1.00 32.58  ?  471  SER   C N     1 
ATOM   2488 C CA    . SER   A 1 471  ? 105.160 167.715 170.745 1.00 31.74  ?  471  SER   C CA    1 
ATOM   2489 C C     . SER   A 1 471  ? 104.740 166.277 170.489 1.00 30.51  ?  471  SER   C C     1 
ATOM   2490 O O     . SER   A 1 471  ? 105.477 165.341 170.799 1.00 30.18  ?  471  SER   C O     1 
ATOM   2491 C CB    . SER   A 1 471  ? 104.485 168.265 171.981 1.00 34.92  ?  471  SER   C CB    1 
ATOM   2492 O OG    . SER   A 1 471  ? 104.821 167.512 173.109 1.00 38.77  ?  471  SER   C OG    1 
ATOM   2493 N N     . LEU   A 1 472  ? 103.563 166.103 169.892 1.00 30.45  ?  472  LEU   C N     1 
ATOM   2494 C CA    . LEU   A 1 472  ? 103.074 164.776 169.553 1.00 31.31  ?  472  LEU   C CA    1 
ATOM   2495 C C     . LEU   A 1 472  ? 104.052 164.071 168.633 1.00 31.32  ?  472  LEU   C C     1 
ATOM   2496 O O     . LEU   A 1 472  ? 104.422 162.915 168.865 1.00 31.79  ?  472  LEU   C O     1 
ATOM   2497 C CB    . LEU   A 1 472  ? 101.713 164.887 168.849 1.00 33.88  ?  472  LEU   C CB    1 
ATOM   2498 C CG    . LEU   A 1 472  ? 101.069 163.571 168.359 1.00 37.09  ?  472  LEU   C CG    1 
ATOM   2499 C CD1   . LEU   A 1 472  ? 100.715 162.695 169.550 1.00 38.07  ?  472  LEU   C CD1   1 
ATOM   2500 C CD2   . LEU   A 1 472  ? 99.838  163.904 167.539 1.00 37.45  ?  472  LEU   C CD2   1 
ATOM   2501 N N     . ALA   A 1 473  ? 104.485 164.764 167.584 1.00 30.46  ?  473  ALA   C N     1 
ATOM   2502 C CA    . ALA   A 1 473  ? 105.412 164.189 166.632 1.00 25.04  ?  473  ALA   C CA    1 
ATOM   2503 C C     . ALA   A 1 473  ? 106.743 163.829 167.290 1.00 24.43  ?  473  ALA   C C     1 
ATOM   2504 O O     . ALA   A 1 473  ? 107.297 162.770 167.044 1.00 25.62  ?  473  ALA   C O     1 
ATOM   2505 C CB    . ALA   A 1 473  ? 105.650 165.143 165.485 1.00 23.82  ?  473  ALA   C CB    1 
ATOM   2506 N N     . ALA   A 1 474  ? 107.229 164.741 168.144 1.00 25.74  ?  474  ALA   C N     1 
ATOM   2507 C CA    . ALA   A 1 474  ? 108.520 164.511 168.800 1.00 25.58  ?  474  ALA   C CA    1 
ATOM   2508 C C     . ALA   A 1 474  ? 108.442 163.302 169.708 1.00 29.81  ?  474  ALA   C C     1 
ATOM   2509 O O     . ALA   A 1 474  ? 109.387 162.496 169.756 1.00 30.32  ?  474  ALA   C O     1 
ATOM   2510 C CB    . ALA   A 1 474  ? 108.903 165.744 169.609 1.00 26.60  ?  474  ALA   C CB    1 
ATOM   2511 N N     . ASP   A 1 475  ? 107.326 163.135 170.394 1.00 33.04  ?  475  ASP   C N     1 
ATOM   2512 C CA    . ASP   A 1 475  ? 107.144 162.006 171.281 1.00 33.45  ?  475  ASP   C CA    1 
ATOM   2513 C C     . ASP   A 1 475  ? 107.187 160.721 170.479 1.00 32.14  ?  475  ASP   C C     1 
ATOM   2514 O O     . ASP   A 1 475  ? 107.844 159.756 170.865 1.00 34.41  ?  475  ASP   C O     1 
ATOM   2515 C CB    . ASP   A 1 475  ? 105.810 162.106 172.020 1.00 36.83  ?  475  ASP   C CB    1 
ATOM   2516 C CG    . ASP   A 1 475  ? 105.675 161.109 173.167 1.00 45.50  ?  475  ASP   C CG    1 
ATOM   2517 O OD1   . ASP   A 1 475  ? 106.191 161.380 174.227 1.00 50.97  ?  475  ASP   C OD1   1 
ATOM   2518 O OD2   . ASP   A 1 475  ? 105.083 160.071 172.968 1.00 45.31  -1 475  ASP   C OD2   1 
ATOM   2519 N N     . GLY   A 1 476  ? 106.508 160.726 169.336 1.00 32.40  ?  476  GLY   C N     1 
ATOM   2520 C CA    . GLY   A 1 476  ? 106.456 159.554 168.477 1.00 30.47  ?  476  GLY   C CA    1 
ATOM   2521 C C     . GLY   A 1 476  ? 107.833 159.126 167.991 1.00 29.72  ?  476  GLY   C C     1 
ATOM   2522 O O     . GLY   A 1 476  ? 108.101 157.934 167.845 1.00 30.91  ?  476  GLY   C O     1 
ATOM   2523 N N     . ILE   A 1 477  ? 108.716 160.082 167.739 1.00 30.01  ?  477  ILE   C N     1 
ATOM   2524 C CA    . ILE   A 1 477  ? 110.045 159.718 167.272 1.00 27.90  ?  477  ILE   C CA    1 
ATOM   2525 C C     . ILE   A 1 477  ? 110.842 159.050 168.381 1.00 29.75  ?  477  ILE   C C     1 
ATOM   2526 O O     . ILE   A 1 477  ? 111.459 158.000 168.177 1.00 30.46  ?  477  ILE   C O     1 
ATOM   2527 C CB    . ILE   A 1 477  ? 110.821 160.953 166.767 1.00 26.31  ?  477  ILE   C CB    1 
ATOM   2528 C CG1   . ILE   A 1 477  ? 110.126 161.595 165.536 1.00 22.08  ?  477  ILE   C CG1   1 
ATOM   2529 C CG2   . ILE   A 1 477  ? 112.258 160.580 166.438 1.00 28.92  ?  477  ILE   C CG2   1 
ATOM   2530 C CD1   . ILE   A 1 477  ? 109.956 160.694 164.333 1.00 21.97  ?  477  ILE   C CD1   1 
ATOM   2531 N N     . TRP   A 1 478  ? 110.819 159.652 169.565 1.00 32.73  ?  478  TRP   C N     1 
ATOM   2532 C CA    . TRP   A 1 478  ? 111.595 159.146 170.689 1.00 34.52  ?  478  TRP   C CA    1 
ATOM   2533 C C     . TRP   A 1 478  ? 111.035 157.860 171.287 1.00 35.14  ?  478  TRP   C C     1 
ATOM   2534 O O     . TRP   A 1 478  ? 111.792 157.016 171.766 1.00 36.00  ?  478  TRP   C O     1 
ATOM   2535 C CB    . TRP   A 1 478  ? 111.699 160.214 171.773 1.00 37.45  ?  478  TRP   C CB    1 
ATOM   2536 C CG    . TRP   A 1 478  ? 112.727 161.254 171.473 1.00 41.11  ?  478  TRP   C CG    1 
ATOM   2537 C CD1   . TRP   A 1 478  ? 112.508 162.553 171.136 1.00 42.62  ?  478  TRP   C CD1   1 
ATOM   2538 C CD2   . TRP   A 1 478  ? 114.159 161.080 171.479 1.00 40.59  ?  478  TRP   C CD2   1 
ATOM   2539 N NE1   . TRP   A 1 478  ? 113.702 163.196 170.936 1.00 42.45  ?  478  TRP   C NE1   1 
ATOM   2540 C CE2   . TRP   A 1 478  ? 114.720 162.311 171.145 1.00 44.52  ?  478  TRP   C CE2   1 
ATOM   2541 C CE3   . TRP   A 1 478  ? 114.999 159.998 171.745 1.00 35.42  ?  478  TRP   C CE3   1 
ATOM   2542 C CZ2   . TRP   A 1 478  ? 116.082 162.492 171.060 1.00 42.77  ?  478  TRP   C CZ2   1 
ATOM   2543 C CZ3   . TRP   A 1 478  ? 116.372 160.183 171.657 1.00 41.94  ?  478  TRP   C CZ3   1 
ATOM   2544 C CH2   . TRP   A 1 478  ? 116.896 161.396 171.325 1.00 41.88  ?  478  TRP   C CH2   1 
ATOM   2545 N N     . ASN   A 1 479  ? 109.716 157.703 171.255 1.00 33.69  ?  479  ASN   C N     1 
ATOM   2546 C CA    . ASN   A 1 479  ? 109.083 156.521 171.826 1.00 31.26  ?  479  ASN   C CA    1 
ATOM   2547 C C     . ASN   A 1 479  ? 108.723 155.497 170.763 1.00 32.46  ?  479  ASN   C C     1 
ATOM   2548 O O     . ASN   A 1 479  ? 108.043 154.512 171.047 1.00 33.83  ?  479  ASN   C O     1 
ATOM   2549 C CB    . ASN   A 1 479  ? 107.855 156.910 172.619 1.00 32.24  ?  479  ASN   C CB    1 
ATOM   2550 C CG    . ASN   A 1 479  ? 108.201 157.697 173.840 1.00 41.27  ?  479  ASN   C CG    1 
ATOM   2551 O OD1   . ASN   A 1 479  ? 109.216 157.437 174.499 1.00 39.73  ?  479  ASN   C OD1   1 
ATOM   2552 N ND2   . ASN   A 1 479  ? 107.382 158.659 174.163 1.00 39.40  ?  479  ASN   C ND2   1 
ATOM   2553 N N     . GLN   A 1 480  ? 109.184 155.728 169.540 1.00 32.40  ?  480  GLN   C N     1 
ATOM   2554 C CA    . GLN   A 1 480  ? 108.929 154.817 168.433 1.00 31.02  ?  480  GLN   C CA    1 
ATOM   2555 C C     . GLN   A 1 480  ? 107.452 154.493 168.261 1.00 29.75  ?  480  GLN   C C     1 
ATOM   2556 O O     . GLN   A 1 480  ? 107.030 153.343 168.381 1.00 31.41  ?  480  GLN   C O     1 
ATOM   2557 C CB    . GLN   A 1 480  ? 109.764 153.551 168.598 1.00 30.49  ?  480  GLN   C CB    1 
ATOM   2558 C CG    . GLN   A 1 480  ? 111.235 153.803 168.392 1.00 31.46  ?  480  GLN   C CG    1 
ATOM   2559 C CD    . GLN   A 1 480  ? 111.540 154.047 166.927 1.00 32.07  ?  480  GLN   C CD    1 
ATOM   2560 O OE1   . GLN   A 1 480  ? 111.565 153.094 166.137 1.00 31.07  ?  480  GLN   C OE1   1 
ATOM   2561 N NE2   . GLN   A 1 480  ? 111.750 155.312 166.546 1.00 30.83  ?  480  GLN   C NE2   1 
ATOM   2562 N N     . LYS   A 1 481  ? 106.667 155.531 168.012 1.00 31.44  ?  481  LYS   C N     1 
ATOM   2563 C CA    . LYS   A 1 481  ? 105.232 155.402 167.841 1.00 31.36  ?  481  LYS   C CA    1 
ATOM   2564 C C     . LYS   A 1 481  ? 104.763 156.203 166.626 1.00 34.28  ?  481  LYS   C C     1 
ATOM   2565 O O     . LYS   A 1 481  ? 104.974 157.415 166.546 1.00 35.87  ?  481  LYS   C O     1 
ATOM   2566 C CB    . LYS   A 1 481  ? 104.544 155.862 169.126 1.00 34.75  ?  481  LYS   C CB    1 
ATOM   2567 C CG    . LYS   A 1 481  ? 103.048 155.681 169.191 1.00 42.68  ?  481  LYS   C CG    1 
ATOM   2568 C CD    . LYS   A 1 481  ? 102.558 156.007 170.600 1.00 52.14  ?  481  LYS   C CD    1 
ATOM   2569 C CE    . LYS   A 1 481  ? 101.077 155.758 170.761 1.00 59.64  ?  481  LYS   C CE    1 
ATOM   2570 N NZ    . LYS   A 1 481  ? 100.640 155.948 172.178 1.00 59.57  1  481  LYS   C NZ    1 
ATOM   2571 N N     . ILE   A 1 482  ? 104.126 155.519 165.680 1.00 33.51  ?  482  ILE   C N     1 
ATOM   2572 C CA    . ILE   A 1 482  ? 103.583 156.175 164.493 1.00 34.81  ?  482  ILE   C CA    1 
ATOM   2573 C C     . ILE   A 1 482  ? 102.072 156.304 164.563 1.00 40.36  ?  482  ILE   C C     1 
ATOM   2574 O O     . ILE   A 1 482  ? 101.509 157.314 164.143 1.00 42.29  ?  482  ILE   C O     1 
ATOM   2575 C CB    . ILE   A 1 482  ? 103.975 155.447 163.200 1.00 36.65  ?  482  ILE   C CB    1 
ATOM   2576 C CG1   . ILE   A 1 482  ? 105.491 155.532 163.006 1.00 38.28  ?  482  ILE   C CG1   1 
ATOM   2577 C CG2   . ILE   A 1 482  ? 103.233 156.066 162.011 1.00 41.39  ?  482  ILE   C CG2   1 
ATOM   2578 C CD1   . ILE   A 1 482  ? 106.023 154.669 161.878 1.00 35.56  ?  482  ILE   C CD1   1 
ATOM   2579 N N     . LEU   A 1 483  ? 101.416 155.249 165.033 1.00 40.65  ?  483  LEU   C N     1 
ATOM   2580 C CA    . LEU   A 1 483  ? 99.967  155.245 165.136 1.00 39.90  ?  483  LEU   C CA    1 
ATOM   2581 C C     . LEU   A 1 483  ? 99.563  155.755 166.504 1.00 43.12  ?  483  LEU   C C     1 
ATOM   2582 O O     . LEU   A 1 483  ? 100.092 155.307 167.521 1.00 44.70  ?  483  LEU   C O     1 
ATOM   2583 C CB    . LEU   A 1 483  ? 99.416  153.828 164.935 1.00 44.83  ?  483  LEU   C CB    1 
ATOM   2584 C CG    . LEU   A 1 483  ? 99.727  153.150 163.588 1.00 43.65  ?  483  LEU   C CG    1 
ATOM   2585 C CD1   . LEU   A 1 483  ? 99.221  151.716 163.629 1.00 52.95  ?  483  LEU   C CD1   1 
ATOM   2586 C CD2   . LEU   A 1 483  ? 99.058  153.919 162.454 1.00 43.67  ?  483  LEU   C CD2   1 
ATOM   2587 N N     . PHE   A 1 484  ? 98.620  156.680 166.529 1.00 44.69  ?  484  PHE   C N     1 
ATOM   2588 C CA    . PHE   A 1 484  ? 98.169  157.279 167.770 1.00 48.20  ?  484  PHE   C CA    1 
ATOM   2589 C C     . PHE   A 1 484  ? 96.689  157.026 168.006 1.00 55.97  ?  484  PHE   C C     1 
ATOM   2590 O O     . PHE   A 1 484  ? 95.916  156.854 167.061 1.00 56.35  ?  484  PHE   C O     1 
ATOM   2591 C CB    . PHE   A 1 484  ? 98.438  158.782 167.739 1.00 47.73  ?  484  PHE   C CB    1 
ATOM   2592 C CG    . PHE   A 1 484  ? 99.892  159.119 167.593 1.00 47.56  ?  484  PHE   C CG    1 
ATOM   2593 C CD1   . PHE   A 1 484  ? 100.411 159.460 166.357 1.00 45.45  ?  484  PHE   C CD1   1 
ATOM   2594 C CD2   . PHE   A 1 484  ? 100.747 159.084 168.680 1.00 50.33  ?  484  PHE   C CD2   1 
ATOM   2595 C CE1   . PHE   A 1 484  ? 101.746 159.763 166.212 1.00 40.68  ?  484  PHE   C CE1   1 
ATOM   2596 C CE2   . PHE   A 1 484  ? 102.084 159.388 168.536 1.00 45.75  ?  484  PHE   C CE2   1 
ATOM   2597 C CZ    . PHE   A 1 484  ? 102.581 159.727 167.299 1.00 42.82  ?  484  PHE   C CZ    1 
ATOM   2598 N N     . GLU   A 1 485  ? 96.294  157.013 169.274 1.00 55.76  ?  485  GLU   C N     1 
ATOM   2599 C CA    . GLU   A 1 485  ? 94.892  156.879 169.643 1.00 54.95  ?  485  GLU   C CA    1 
ATOM   2600 C C     . GLU   A 1 485  ? 94.355  158.223 170.118 1.00 57.98  ?  485  GLU   C C     1 
ATOM   2601 O O     . GLU   A 1 485  ? 95.114  159.183 170.261 1.00 57.28  ?  485  GLU   C O     1 
ATOM   2602 C CB    . GLU   A 1 485  ? 94.730  155.830 170.742 1.00 57.12  ?  485  GLU   C CB    1 
ATOM   2603 C CG    . GLU   A 1 485  ? 95.221  154.438 170.364 1.00 61.41  ?  485  GLU   C CG    1 
ATOM   2604 C CD    . GLU   A 1 485  ? 94.970  153.417 171.442 1.00 60.46  ?  485  GLU   C CD    1 
ATOM   2605 O OE1   . GLU   A 1 485  ? 94.219  153.709 172.342 1.00 51.80  ?  485  GLU   C OE1   1 
ATOM   2606 O OE2   . GLU   A 1 485  ? 95.537  152.352 171.372 1.00 64.76  -1 485  GLU   C OE2   1 
ATOM   2607 N N     . GLU   A 1 486  ? 93.061  158.288 170.416 1.00 59.91  ?  486  GLU   C N     1 
ATOM   2608 C CA    . GLU   A 1 486  ? 92.481  159.537 170.894 1.00 62.74  ?  486  GLU   C CA    1 
ATOM   2609 C C     . GLU   A 1 486  ? 93.153  159.991 172.182 1.00 60.55  ?  486  GLU   C C     1 
ATOM   2610 O O     . GLU   A 1 486  ? 93.285  161.189 172.432 1.00 60.61  ?  486  GLU   C O     1 
ATOM   2611 C CB    . GLU   A 1 486  ? 90.986  159.397 171.134 1.00 67.66  ?  486  GLU   C CB    1 
ATOM   2612 C CG    . GLU   A 1 486  ? 90.140  159.226 169.895 1.00 72.74  ?  486  GLU   C CG    1 
ATOM   2613 C CD    . GLU   A 1 486  ? 88.665  159.169 170.221 1.00 74.29  ?  486  GLU   C CD    1 
ATOM   2614 O OE1   . GLU   A 1 486  ? 88.321  159.285 171.380 1.00 67.07  ?  486  GLU   C OE1   1 
ATOM   2615 O OE2   . GLU   A 1 486  ? 87.883  159.025 169.311 1.00 79.60  -1 486  GLU   C OE2   1 
ATOM   2616 N N     . SER   A 1 487  ? 93.581  159.033 172.999 1.00 62.68  ?  487  SER   C N     1 
ATOM   2617 C CA    . SER   A 1 487  ? 94.244  159.345 174.256 1.00 64.29  ?  487  SER   C CA    1 
ATOM   2618 C C     . SER   A 1 487  ? 95.554  160.083 174.022 1.00 54.59  ?  487  SER   C C     1 
ATOM   2619 O O     . SER   A 1 487  ? 95.942  160.939 174.816 1.00 60.45  ?  487  SER   C O     1 
ATOM   2620 C CB    . SER   A 1 487  ? 94.524  158.073 175.033 1.00 65.46  ?  487  SER   C CB    1 
ATOM   2621 O OG    . SER   A 1 487  ? 93.335  157.444 175.430 1.00 74.15  ?  487  SER   C OG    1 
ATOM   2622 N N     . ASP   A 1 488  ? 96.234  159.762 172.925 1.00 54.27  ?  488  ASP   C N     1 
ATOM   2623 C CA    . ASP   A 1 488  ? 97.539  160.336 172.652 1.00 53.96  ?  488  ASP   C CA    1 
ATOM   2624 C C     . ASP   A 1 488  ? 97.369  161.733 172.105 1.00 53.71  ?  488  ASP   C C     1 
ATOM   2625 O O     . ASP   A 1 488  ? 98.193  162.616 172.344 1.00 50.28  ?  488  ASP   C O     1 
ATOM   2626 C CB    . ASP   A 1 488  ? 98.278  159.493 171.622 1.00 54.45  ?  488  ASP   C CB    1 
ATOM   2627 C CG    . ASP   A 1 488  ? 98.602  158.097 172.096 1.00 59.02  ?  488  ASP   C CG    1 
ATOM   2628 O OD1   . ASP   A 1 488  ? 99.412  157.942 172.986 1.00 59.17  ?  488  ASP   C OD1   1 
ATOM   2629 O OD2   . ASP   A 1 488  ? 98.049  157.170 171.542 1.00 57.94  -1 488  ASP   C OD2   1 
ATOM   2630 N N     . LEU   A 1 489  ? 96.286  161.940 171.374 1.00 54.94  ?  489  LEU   C N     1 
ATOM   2631 C CA    . LEU   A 1 489  ? 96.009  163.262 170.855 1.00 53.86  ?  489  LEU   C CA    1 
ATOM   2632 C C     . LEU   A 1 489  ? 95.629  164.184 172.007 1.00 57.58  ?  489  LEU   C C     1 
ATOM   2633 O O     . LEU   A 1 489  ? 96.164  165.287 172.136 1.00 54.79  ?  489  LEU   C O     1 
ATOM   2634 C CB    . LEU   A 1 489  ? 94.873  163.192 169.825 1.00 53.66  ?  489  LEU   C CB    1 
ATOM   2635 C CG    . LEU   A 1 489  ? 95.191  162.449 168.504 1.00 53.87  ?  489  LEU   C CG    1 
ATOM   2636 C CD1   . LEU   A 1 489  ? 93.909  162.251 167.719 1.00 61.67  ?  489  LEU   C CD1   1 
ATOM   2637 C CD2   . LEU   A 1 489  ? 96.182  163.256 167.687 1.00 52.45  ?  489  LEU   C CD2   1 
ATOM   2638 N N     . ARG   A 1 490  ? 94.772  163.696 172.900 1.00 56.57  ?  490  ARG   C N     1 
ATOM   2639 C CA    . ARG   A 1 490  ? 94.345  164.495 174.041 1.00 57.57  ?  490  ARG   C CA    1 
ATOM   2640 C C     . ARG   A 1 490  ? 95.514  164.833 174.955 1.00 54.63  ?  490  ARG   C C     1 
ATOM   2641 O O     . ARG   A 1 490  ? 95.600  165.947 175.475 1.00 57.52  ?  490  ARG   C O     1 
ATOM   2642 C CB    . ARG   A 1 490  ? 93.262  163.778 174.834 1.00 61.09  ?  490  ARG   C CB    1 
ATOM   2643 C CG    . ARG   A 1 490  ? 91.890  163.764 174.161 1.00 64.35  ?  490  ARG   C CG    1 
ATOM   2644 C CD    . ARG   A 1 490  ? 90.809  163.339 175.099 1.00 69.10  ?  490  ARG   C CD    1 
ATOM   2645 N NE    . ARG   A 1 490  ? 90.909  161.927 175.466 1.00 68.80  ?  490  ARG   C NE    1 
ATOM   2646 C CZ    . ARG   A 1 490  ? 90.315  160.910 174.800 1.00 71.34  ?  490  ARG   C CZ    1 
ATOM   2647 N NH1   . ARG   A 1 490  ? 89.570  161.155 173.743 1.00 70.94  1  490  ARG   C NH1   1 
ATOM   2648 N NH2   . ARG   A 1 490  ? 90.478  159.665 175.215 1.00 70.96  ?  490  ARG   C NH2   1 
ATOM   2649 N N     . ASN   A 1 491  ? 96.441  163.892 175.113 1.00 54.50  ?  491  ASN   C N     1 
ATOM   2650 C CA    . ASN   A 1 491  ? 97.591  164.086 175.988 1.00 55.44  ?  491  ASN   C CA    1 
ATOM   2651 C C     . ASN   A 1 491  ? 98.506  165.205 175.509 1.00 52.93  ?  491  ASN   C C     1 
ATOM   2652 O O     . ASN   A 1 491  ? 99.354  165.680 176.265 1.00 52.37  ?  491  ASN   C O     1 
ATOM   2653 C CB    . ASN   A 1 491  ? 98.385  162.801 176.132 1.00 51.45  ?  491  ASN   C CB    1 
ATOM   2654 C CG    . ASN   A 1 491  ? 97.705  161.792 177.002 1.00 53.79  ?  491  ASN   C CG    1 
ATOM   2655 O OD1   . ASN   A 1 491  ? 96.812  162.130 177.790 1.00 60.89  ?  491  ASN   C OD1   1 
ATOM   2656 N ND2   . ASN   A 1 491  ? 98.108  160.554 176.883 1.00 53.16  ?  491  ASN   C ND2   1 
ATOM   2657 N N     . HIS   A 1 492  ? 98.361  165.607 174.249 1.00 49.95  ?  492  HIS   C N     1 
ATOM   2658 C CA    . HIS   A 1 492  ? 99.198  166.653 173.691 1.00 50.17  ?  492  HIS   C CA    1 
ATOM   2659 C C     . HIS   A 1 492  ? 98.394  167.896 173.337 1.00 52.82  ?  492  HIS   C C     1 
ATOM   2660 O O     . HIS   A 1 492  ? 98.891  168.790 172.656 1.00 52.57  ?  492  HIS   C O     1 
ATOM   2661 C CB    . HIS   A 1 492  ? 99.947  166.135 172.463 1.00 44.67  ?  492  HIS   C CB    1 
ATOM   2662 C CG    . HIS   A 1 492  ? 100.959 165.089 172.792 1.00 39.39  ?  492  HIS   C CG    1 
ATOM   2663 N ND1   . HIS   A 1 492  ? 100.651 163.750 172.890 1.00 42.84  ?  492  HIS   C ND1   1 
ATOM   2664 C CD2   . HIS   A 1 492  ? 102.272 165.190 173.056 1.00 37.39  ?  492  HIS   C CD2   1 
ATOM   2665 C CE1   . HIS   A 1 492  ? 101.743 163.075 173.196 1.00 41.33  ?  492  HIS   C CE1   1 
ATOM   2666 N NE2   . HIS   A 1 492  ? 102.738 163.926 173.302 1.00 37.79  ?  492  HIS   C NE2   1 
ATOM   2667 N N     . GLY   A 1 493  ? 97.158  167.967 173.822 1.00 57.97  ?  493  GLY   C N     1 
ATOM   2668 C CA    . GLY   A 1 493  ? 96.322  169.139 173.590 1.00 61.30  ?  493  GLY   C CA    1 
ATOM   2669 C C     . GLY   A 1 493  ? 95.537  169.096 172.279 1.00 60.84  ?  493  GLY   C C     1 
ATOM   2670 O O     . GLY   A 1 493  ? 95.028  170.124 171.834 1.00 62.47  ?  493  GLY   C O     1 
ATOM   2671 N N     . LEU   A 1 494  ? 95.432  167.922 171.662 1.00 59.20  ?  494  LEU   C N     1 
ATOM   2672 C CA    . LEU   A 1 494  ? 94.686  167.787 170.415 1.00 62.27  ?  494  LEU   C CA    1 
ATOM   2673 C C     . LEU   A 1 494  ? 93.381  167.051 170.678 1.00 65.59  ?  494  LEU   C C     1 
ATOM   2674 O O     . LEU   A 1 494  ? 93.393  165.902 171.115 1.00 61.97  ?  494  LEU   C O     1 
ATOM   2675 C CB    . LEU   A 1 494  ? 95.495  167.005 169.365 1.00 62.10  ?  494  LEU   C CB    1 
ATOM   2676 C CG    . LEU   A 1 494  ? 96.660  167.747 168.682 1.00 59.31  ?  494  LEU   C CG    1 
ATOM   2677 C CD1   . LEU   A 1 494  ? 97.940  167.541 169.489 1.00 54.70  ?  494  LEU   C CD1   1 
ATOM   2678 C CD2   . LEU   A 1 494  ? 96.823  167.220 167.256 1.00 56.52  ?  494  LEU   C CD2   1 
ATOM   2679 N N     . GLN   A 1 495  ? 92.250  167.707 170.450 1.00 70.59  ?  495  GLN   C N     1 
ATOM   2680 C CA    . GLN   A 1 495  ? 90.982  167.067 170.761 1.00 73.30  ?  495  GLN   C CA    1 
ATOM   2681 C C     . GLN   A 1 495  ? 89.841  167.501 169.855 1.00 73.57  ?  495  GLN   C C     1 
ATOM   2682 O O     . GLN   A 1 495  ? 89.327  168.616 169.961 1.00 72.73  ?  495  GLN   C O     1 
ATOM   2683 C CB    . GLN   A 1 495  ? 90.603  167.324 172.218 1.00 73.47  ?  495  GLN   C CB    1 
ATOM   2684 C CG    . GLN   A 1 495  ? 89.330  166.624 172.656 1.00 77.53  ?  495  GLN   C CG    1 
ATOM   2685 C CD    . GLN   A 1 495  ? 89.046  166.802 174.127 1.00 80.77  ?  495  GLN   C CD    1 
ATOM   2686 O OE1   . GLN   A 1 495  ? 89.942  166.690 174.967 1.00 77.12  ?  495  GLN   C OE1   1 
ATOM   2687 N NE2   . GLN   A 1 495  ? 87.791  167.083 174.453 1.00 77.86  ?  495  GLN   C NE2   1 
ATOM   2688 N N     . LYS   A 1 496  ? 89.430  166.576 168.994 1.00 71.41  ?  496  LYS   C N     1 
ATOM   2689 C CA    . LYS   A 1 496  ? 88.300  166.726 168.080 1.00 74.28  ?  496  LYS   C CA    1 
ATOM   2690 C C     . LYS   A 1 496  ? 88.367  167.926 167.135 1.00 72.78  ?  496  LYS   C C     1 
ATOM   2691 O O     . LYS   A 1 496  ? 88.469  167.751 165.922 1.00 70.47  ?  496  LYS   C O     1 
ATOM   2692 C CB    . LYS   A 1 496  ? 86.998  166.778 168.879 1.00 76.99  ?  496  LYS   C CB    1 
ATOM   2693 C CG    . LYS   A 1 496  ? 86.730  165.537 169.742 1.00 74.44  ?  496  LYS   C CG    1 
ATOM   2694 C CD    . LYS   A 1 496  ? 86.534  164.278 168.899 1.00 70.42  ?  496  LYS   C CD    1 
ATOM   2695 C CE    . LYS   A 1 496  ? 86.176  163.082 169.772 1.00 86.08  ?  496  LYS   C CE    1 
ATOM   2696 N NZ    . LYS   A 1 496  ? 86.067  161.825 168.978 1.00 81.97  1  496  LYS   C NZ    1 
ATOM   2697 N N     . ALA   A 1 497  ? 88.229  169.135 167.675 1.00 76.55  ?  497  ALA   C N     1 
ATOM   2698 C CA    . ALA   A 1 497  ? 88.068  170.317 166.831 1.00 75.68  ?  497  ALA   C CA    1 
ATOM   2699 C C     . ALA   A 1 497  ? 89.308  170.600 165.993 1.00 70.73  ?  497  ALA   C C     1 
ATOM   2700 O O     . ALA   A 1 497  ? 89.202  170.861 164.791 1.00 69.33  ?  497  ALA   C O     1 
ATOM   2701 C CB    . ALA   A 1 497  ? 87.742  171.524 167.696 1.00 84.59  ?  497  ALA   C CB    1 
ATOM   2702 N N     . ASP   A 1 498  ? 90.484  170.538 166.608 1.00 76.05  ?  498  ASP   C N     1 
ATOM   2703 C CA    . ASP   A 1 498  ? 91.710  170.803 165.873 1.00 72.79  ?  498  ASP   C CA    1 
ATOM   2704 C C     . ASP   A 1 498  ? 92.126  169.572 165.094 1.00 65.46  ?  498  ASP   C C     1 
ATOM   2705 O O     . ASP   A 1 498  ? 92.756  169.674 164.043 1.00 60.33  ?  498  ASP   C O     1 
ATOM   2706 C CB    . ASP   A 1 498  ? 92.823  171.238 166.821 1.00 72.45  ?  498  ASP   C CB    1 
ATOM   2707 C CG    . ASP   A 1 498  ? 93.080  170.225 167.898 1.00 68.88  ?  498  ASP   C CG    1 
ATOM   2708 O OD1   . ASP   A 1 498  ? 92.147  169.870 168.593 1.00 69.23  ?  498  ASP   C OD1   1 
ATOM   2709 O OD2   . ASP   A 1 498  ? 94.194  169.803 168.027 1.00 66.80  -1 498  ASP   C OD2   1 
ATOM   2710 N N     . VAL   A 1 499  ? 91.732  168.409 165.590 1.00 72.29  ?  499  VAL   C N     1 
ATOM   2711 C CA    . VAL   A 1 499  ? 92.059  167.173 164.914 1.00 63.52  ?  499  VAL   C CA    1 
ATOM   2712 C C     . VAL   A 1 499  ? 91.334  167.142 163.588 1.00 63.10  ?  499  VAL   C C     1 
ATOM   2713 O O     . VAL   A 1 499  ? 91.932  166.846 162.558 1.00 59.70  ?  499  VAL   C O     1 
ATOM   2714 C CB    . VAL   A 1 499  ? 91.667  165.967 165.779 1.00 70.40  ?  499  VAL   C CB    1 
ATOM   2715 C CG1   . VAL   A 1 499  ? 91.851  164.662 164.994 1.00 67.40  ?  499  VAL   C CG1   1 
ATOM   2716 C CG2   . VAL   A 1 499  ? 92.531  165.973 167.033 1.00 66.09  ?  499  VAL   C CG2   1 
ATOM   2717 N N     . SER   A 1 500  ? 90.054  167.496 163.611 1.00 71.02  ?  500  SER   C N     1 
ATOM   2718 C CA    . SER   A 1 500  ? 89.261  167.566 162.398 1.00 65.89  ?  500  SER   C CA    1 
ATOM   2719 C C     . SER   A 1 500  ? 89.858  168.593 161.455 1.00 63.13  ?  500  SER   C C     1 
ATOM   2720 O O     . SER   A 1 500  ? 89.986  168.351 160.254 1.00 62.31  ?  500  SER   C O     1 
ATOM   2721 C CB    . SER   A 1 500  ? 87.829  167.928 162.721 1.00 76.99  ?  500  SER   C CB    1 
ATOM   2722 O OG    . SER   A 1 500  ? 87.052  168.001 161.558 1.00 74.96  ?  500  SER   C OG    1 
ATOM   2723 N N     . ALA   A 1 501  ? 90.276  169.732 162.003 1.00 61.27  ?  501  ALA   C N     1 
ATOM   2724 C CA    . ALA   A 1 501  ? 90.883  170.760 161.178 1.00 64.71  ?  501  ALA   C CA    1 
ATOM   2725 C C     . ALA   A 1 501  ? 92.076  170.197 160.427 1.00 105.96 ?  501  ALA   C C     1 
ATOM   2726 O O     . ALA   A 1 501  ? 92.280  170.536 159.262 1.00 62.52  ?  501  ALA   C O     1 
ATOM   2727 C CB    . ALA   A 1 501  ? 91.321  171.942 162.027 1.00 62.77  ?  501  ALA   C CB    1 
ATOM   2728 N N     . PHE   A 1 502  ? 92.827  169.301 161.073 1.00 58.01  ?  502  PHE   C N     1 
ATOM   2729 C CA    . PHE   A 1 502  ? 94.029  168.720 160.480 1.00 56.14  ?  502  PHE   C CA    1 
ATOM   2730 C C     . PHE   A 1 502  ? 93.724  167.520 159.586 1.00 62.29  ?  502  PHE   C C     1 
ATOM   2731 O O     . PHE   A 1 502  ? 94.639  166.883 159.051 1.00 54.04  ?  502  PHE   C O     1 
ATOM   2732 C CB    . PHE   A 1 502  ? 95.008  168.291 161.561 1.00 57.48  ?  502  PHE   C CB    1 
ATOM   2733 C CG    . PHE   A 1 502  ? 95.514  169.387 162.434 1.00 60.01  ?  502  PHE   C CG    1 
ATOM   2734 C CD1   . PHE   A 1 502  ? 95.691  169.158 163.785 1.00 60.50  ?  502  PHE   C CD1   1 
ATOM   2735 C CD2   . PHE   A 1 502  ? 95.819  170.643 161.927 1.00 61.02  ?  502  PHE   C CD2   1 
ATOM   2736 C CE1   . PHE   A 1 502  ? 96.160  170.150 164.613 1.00 61.23  ?  502  PHE   C CE1   1 
ATOM   2737 C CE2   . PHE   A 1 502  ? 96.286  171.636 162.750 1.00 62.09  ?  502  PHE   C CE2   1 
ATOM   2738 C CZ    . PHE   A 1 502  ? 96.459  171.390 164.096 1.00 61.73  ?  502  PHE   C CZ    1 
ATOM   2739 N N     . LEU   A 1 503  ? 92.442  167.217 159.412 1.00 62.45  ?  503  LEU   C N     1 
ATOM   2740 C CA    . LEU   A 1 503  ? 92.024  166.207 158.456 1.00 64.12  ?  503  LEU   C CA    1 
ATOM   2741 C C     . LEU   A 1 503  ? 91.480  166.936 157.234 1.00 61.57  ?  503  LEU   C C     1 
ATOM   2742 O O     . LEU   A 1 503  ? 91.708  166.530 156.097 1.00 60.63  ?  503  LEU   C O     1 
ATOM   2743 C CB    . LEU   A 1 503  ? 90.965  165.268 159.054 1.00 66.25  ?  503  LEU   C CB    1 
ATOM   2744 C CG    . LEU   A 1 503  ? 91.394  164.452 160.298 1.00 71.47  ?  503  LEU   C CG    1 
ATOM   2745 C CD1   . LEU   A 1 503  ? 90.199  163.683 160.821 1.00 74.47  ?  503  LEU   C CD1   1 
ATOM   2746 C CD2   . LEU   A 1 503  ? 92.531  163.500 159.948 1.00 56.42  ?  503  LEU   C CD2   1 
ATOM   2747 N N     . ARG   A 1 504  ? 90.801  168.059 157.477 1.00 67.04  ?  504  ARG   C N     1 
ATOM   2748 C CA    . ARG   A 1 504  ? 90.331  168.902 156.383 1.00 67.29  ?  504  ARG   C CA    1 
ATOM   2749 C C     . ARG   A 1 504  ? 91.534  169.334 155.559 1.00 68.58  ?  504  ARG   C C     1 
ATOM   2750 O O     . ARG   A 1 504  ? 91.570  169.151 154.341 1.00 67.97  ?  504  ARG   C O     1 
ATOM   2751 C CB    . ARG   A 1 504  ? 89.589  170.120 156.903 1.00 63.17  ?  504  ARG   C CB    1 
ATOM   2752 C CG    . ARG   A 1 504  ? 89.045  171.041 155.819 1.00 63.10  ?  504  ARG   C CG    1 
ATOM   2753 C CD    . ARG   A 1 504  ? 88.497  172.298 156.386 1.00 67.95  ?  504  ARG   C CD    1 
ATOM   2754 N NE    . ARG   A 1 504  ? 89.510  173.062 157.104 1.00 65.53  ?  504  ARG   C NE    1 
ATOM   2755 C CZ    . ARG   A 1 504  ? 90.483  173.797 156.524 1.00 67.08  ?  504  ARG   C CZ    1 
ATOM   2756 N NH1   . ARG   A 1 504  ? 90.579  173.858 155.211 1.00 58.56  1  504  ARG   C NH1   1 
ATOM   2757 N NH2   . ARG   A 1 504  ? 91.343  174.458 157.273 1.00 63.27  ?  504  ARG   C NH2   1 
ATOM   2758 N N     . MET   A 1 505  ? 92.550  169.857 156.240 1.00 64.74  ?  505  MET   C N     1 
ATOM   2759 C CA    . MET   A 1 505  ? 93.837  170.070 155.602 1.00 67.42  ?  505  MET   C CA    1 
ATOM   2760 C C     . MET   A 1 505  ? 94.582  168.763 155.757 1.00 66.24  ?  505  MET   C C     1 
ATOM   2761 O O     . MET   A 1 505  ? 94.399  168.073 156.754 1.00 56.85  ?  505  MET   C O     1 
ATOM   2762 C CB    . MET   A 1 505  ? 94.601  171.224 156.235 1.00 67.44  ?  505  MET   C CB    1 
ATOM   2763 C CG    . MET   A 1 505  ? 95.022  170.984 157.653 1.00 60.02  ?  505  MET   C CG    1 
ATOM   2764 S SD    . MET   A 1 505  ? 95.952  172.334 158.370 1.00 67.02  ?  505  MET   C SD    1 
ATOM   2765 C CE    . MET   A 1 505  ? 94.654  173.482 158.807 1.00 69.13  ?  505  MET   C CE    1 
ATOM   2766 N N     . ASN   A 1 506  ? 95.398  168.395 154.794 1.00 57.17  ?  506  ASN   C N     1 
ATOM   2767 C CA    . ASN   A 1 506  ? 95.978  167.062 154.824 1.00 56.32  ?  506  ASN   C CA    1 
ATOM   2768 C C     . ASN   A 1 506  ? 97.225  166.941 155.699 1.00 50.59  ?  506  ASN   C C     1 
ATOM   2769 O O     . ASN   A 1 506  ? 98.338  166.875 155.187 1.00 48.25  ?  506  ASN   C O     1 
ATOM   2770 C CB    . ASN   A 1 506  ? 96.259  166.598 153.404 1.00 53.88  ?  506  ASN   C CB    1 
ATOM   2771 C CG    . ASN   A 1 506  ? 96.511  165.119 153.293 1.00 57.60  ?  506  ASN   C CG    1 
ATOM   2772 O OD1   . ASN   A 1 506  ? 97.482  164.684 152.673 1.00 50.13  ?  506  ASN   C OD1   1 
ATOM   2773 N ND2   . ASN   A 1 506  ? 95.643  164.332 153.867 1.00 57.95  ?  506  ASN   C ND2   1 
ATOM   2774 N N     . LEU   A 1 507  ? 97.039  166.896 157.019 1.00 49.32  ?  507  LEU   C N     1 
ATOM   2775 C CA    . LEU   A 1 507  ? 98.158  166.661 157.934 1.00 45.93  ?  507  LEU   C CA    1 
ATOM   2776 C C     . LEU   A 1 507  ? 98.109  165.256 158.527 1.00 41.60  ?  507  LEU   C C     1 
ATOM   2777 O O     . LEU   A 1 507  ? 99.146  164.599 158.665 1.00 38.28  ?  507  LEU   C O     1 
ATOM   2778 C CB    . LEU   A 1 507  ? 98.176  167.691 159.066 1.00 45.70  ?  507  LEU   C CB    1 
ATOM   2779 C CG    . LEU   A 1 507  ? 99.099  168.915 158.885 1.00 40.71  ?  507  LEU   C CG    1 
ATOM   2780 C CD1   . LEU   A 1 507  ? 98.680  169.727 157.664 1.00 48.94  ?  507  LEU   C CD1   1 
ATOM   2781 C CD2   . LEU   A 1 507  ? 99.022  169.748 160.146 1.00 44.67  ?  507  LEU   C CD2   1 
ATOM   2782 N N     . PHE   A 1 508  ? 96.905  164.796 158.858 1.00 45.82  ?  508  PHE   C N     1 
ATOM   2783 C CA    . PHE   A 1 508  ? 96.700  163.474 159.447 1.00 43.47  ?  508  PHE   C CA    1 
ATOM   2784 C C     . PHE   A 1 508  ? 95.778  162.584 158.623 1.00 46.56  ?  508  PHE   C C     1 
ATOM   2785 O O     . PHE   A 1 508  ? 94.979  163.059 157.817 1.00 54.07  ?  508  PHE   C O     1 
ATOM   2786 C CB    . PHE   A 1 508  ? 96.118  163.572 160.852 1.00 45.08  ?  508  PHE   C CB    1 
ATOM   2787 C CG    . PHE   A 1 508  ? 97.048  164.056 161.876 1.00 43.36  ?  508  PHE   C CG    1 
ATOM   2788 C CD1   . PHE   A 1 508  ? 97.131  165.387 162.137 1.00 43.99  ?  508  PHE   C CD1   1 
ATOM   2789 C CD2   . PHE   A 1 508  ? 97.830  163.178 162.601 1.00 38.99  ?  508  PHE   C CD2   1 
ATOM   2790 C CE1   . PHE   A 1 508  ? 97.970  165.863 163.098 1.00 43.19  ?  508  PHE   C CE1   1 
ATOM   2791 C CE2   . PHE   A 1 508  ? 98.681  163.639 163.569 1.00 37.33  ?  508  PHE   C CE2   1 
ATOM   2792 C CZ    . PHE   A 1 508  ? 98.749  164.988 163.824 1.00 41.99  ?  508  PHE   C CZ    1 
ATOM   2793 N N     . GLN   A 1 509  ? 95.889  161.282 158.857 1.00 45.31  ?  509  GLN   C N     1 
ATOM   2794 C CA    . GLN   A 1 509  ? 95.009  160.291 158.257 1.00 52.30  ?  509  GLN   C CA    1 
ATOM   2795 C C     . GLN   A 1 509  ? 94.451  159.370 159.343 1.00 57.01  ?  509  GLN   C C     1 
ATOM   2796 O O     . GLN   A 1 509  ? 95.115  159.138 160.353 1.00 54.16  ?  509  GLN   C O     1 
ATOM   2797 C CB    . GLN   A 1 509  ? 95.771  159.488 157.219 1.00 51.98  ?  509  GLN   C CB    1 
ATOM   2798 C CG    . GLN   A 1 509  ? 96.388  160.332 156.146 1.00 50.04  ?  509  GLN   C CG    1 
ATOM   2799 C CD    . GLN   A 1 509  ? 97.258  159.550 155.181 1.00 49.86  ?  509  GLN   C CD    1 
ATOM   2800 O OE1   . GLN   A 1 509  ? 97.986  158.635 155.571 1.00 46.61  ?  509  GLN   C OE1   1 
ATOM   2801 N NE2   . GLN   A 1 509  ? 97.199  159.914 153.909 1.00 50.76  ?  509  GLN   C NE2   1 
ATOM   2802 N N     . LYS   A 1 510  ? 93.234  158.845 159.147 1.00 59.01  ?  510  LYS   C N     1 
ATOM   2803 C CA    . LYS   A 1 510  ? 92.623  157.990 160.169 1.00 62.33  ?  510  LYS   C CA    1 
ATOM   2804 C C     . LYS   A 1 510  ? 92.525  156.492 159.813 1.00 64.78  ?  510  LYS   C C     1 
ATOM   2805 O O     . LYS   A 1 510  ? 92.365  155.654 160.706 1.00 65.64  ?  510  LYS   C O     1 
ATOM   2806 C CB    . LYS   A 1 510  ? 91.238  158.528 160.523 1.00 66.00  ?  510  LYS   C CB    1 
ATOM   2807 C CG    . LYS   A 1 510  ? 90.548  157.830 161.681 1.00 67.74  ?  510  LYS   C CG    1 
ATOM   2808 C CD    . LYS   A 1 510  ? 89.258  158.525 162.034 1.00 64.56  ?  510  LYS   C CD    1 
ATOM   2809 C CE    . LYS   A 1 510  ? 88.569  157.847 163.192 1.00 69.69  ?  510  LYS   C CE    1 
ATOM   2810 N NZ    . LYS   A 1 510  ? 87.299  158.525 163.537 1.00 81.27  1  510  LYS   C NZ    1 
ATOM   2811 N N     . GLU   A 1 511  ? 92.573  156.174 158.509 1.00 65.31  ?  511  GLU   C N     1 
ATOM   2812 C CA    . GLU   A 1 511  ? 92.337  154.817 157.967 1.00 67.78  ?  511  GLU   C CA    1 
ATOM   2813 C C     . GLU   A 1 511  ? 90.837  154.529 157.887 1.00 68.70  ?  511  GLU   C C     1 
ATOM   2814 O O     . GLU   A 1 511  ? 90.078  154.908 158.777 1.00 70.56  ?  511  GLU   C O     1 
ATOM   2815 C CB    . GLU   A 1 511  ? 93.063  153.721 158.782 1.00 69.09  ?  511  GLU   C CB    1 
ATOM   2816 C CG    . GLU   A 1 511  ? 94.598  153.804 158.733 1.00 69.45  ?  511  GLU   C CG    1 
ATOM   2817 C CD    . GLU   A 1 511  ? 95.299  152.738 159.540 1.00 69.32  ?  511  GLU   C CD    1 
ATOM   2818 O OE1   . GLU   A 1 511  ? 94.634  152.013 160.229 1.00 72.98  ?  511  GLU   C OE1   1 
ATOM   2819 O OE2   . GLU   A 1 511  ? 96.507  152.648 159.455 1.00 64.56  -1 511  GLU   C OE2   1 
ATOM   2820 N N     . VAL   A 1 512  ? 90.401  153.904 156.786 1.00 71.63  ?  512  VAL   C N     1 
ATOM   2821 C CA    . VAL   A 1 512  ? 88.966  153.696 156.565 1.00 73.52  ?  512  VAL   C CA    1 
ATOM   2822 C C     . VAL   A 1 512  ? 88.504  152.240 156.511 1.00 75.23  ?  512  VAL   C C     1 
ATOM   2823 O O     . VAL   A 1 512  ? 87.302  151.973 156.561 1.00 57.45  ?  512  VAL   C O     1 
ATOM   2824 C CB    . VAL   A 1 512  ? 88.528  154.394 155.263 1.00 57.47  ?  512  VAL   C CB    1 
ATOM   2825 C CG1   . VAL   A 1 512  ? 88.755  155.866 155.385 1.00 58.23  ?  512  VAL   C CG1   1 
ATOM   2826 C CG2   . VAL   A 1 512  ? 89.314  153.833 154.077 1.00 58.69  ?  512  VAL   C CG2   1 
ATOM   2827 N N     . ASP   A 1 513  ? 89.427  151.291 156.409 1.00 79.63  ?  513  ASP   C N     1 
ATOM   2828 C CA    . ASP   A 1 513  ? 89.006  149.899 156.280 1.00 84.86  ?  513  ASP   C CA    1 
ATOM   2829 C C     . ASP   A 1 513  ? 88.724  149.271 157.642 1.00 85.47  ?  513  ASP   C C     1 
ATOM   2830 O O     . ASP   A 1 513  ? 89.467  148.407 158.107 1.00 85.00  ?  513  ASP   C O     1 
ATOM   2831 C CB    . ASP   A 1 513  ? 90.053  149.063 155.531 1.00 82.94  ?  513  ASP   C CB    1 
ATOM   2832 C CG    . ASP   A 1 513  ? 89.518  147.661 155.119 1.00 82.30  ?  513  ASP   C CG    1 
ATOM   2833 O OD1   . ASP   A 1 513  ? 88.321  147.503 155.055 1.00 84.69  ?  513  ASP   C OD1   1 
ATOM   2834 O OD2   . ASP   A 1 513  ? 90.314  146.778 154.881 1.00 73.41  -1 513  ASP   C OD2   1 
ATOM   2835 N N     . CYS   A 1 514  ? 87.636  149.713 158.270 1.00 78.42  ?  514  CYS   C N     1 
ATOM   2836 C CA    . CYS   A 1 514  ? 87.207  149.199 159.570 1.00 80.03  ?  514  CYS   C CA    1 
ATOM   2837 C C     . CYS   A 1 514  ? 88.297  149.284 160.635 1.00 84.20  ?  514  CYS   C C     1 
ATOM   2838 O O     . CYS   A 1 514  ? 88.523  148.327 161.376 1.00 71.73  ?  514  CYS   C O     1 
ATOM   2839 C CB    . CYS   A 1 514  ? 86.760  147.745 159.440 1.00 88.72  ?  514  CYS   C CB    1 
ATOM   2840 S SG    . CYS   A 1 514  ? 85.423  147.497 158.258 1.00 112.39 ?  514  CYS   C SG    1 
ATOM   2841 N N     . GLU   A 1 515  ? 88.955  150.437 160.714 1.00 82.79  ?  515  GLU   C N     1 
ATOM   2842 C CA    . GLU   A 1 515  ? 90.010  150.674 161.693 1.00 79.28  ?  515  GLU   C CA    1 
ATOM   2843 C C     . GLU   A 1 515  ? 89.967  152.131 162.146 1.00 75.65  ?  515  GLU   C C     1 
ATOM   2844 O O     . GLU   A 1 515  ? 89.445  152.982 161.427 1.00 67.54  ?  515  GLU   C O     1 
ATOM   2845 C CB    . GLU   A 1 515  ? 91.371  150.314 161.088 1.00 76.06  ?  515  GLU   C CB    1 
ATOM   2846 C CG    . GLU   A 1 515  ? 92.544  150.464 162.024 1.00 72.33  ?  515  GLU   C CG    1 
ATOM   2847 C CD    . GLU   A 1 515  ? 92.398  149.654 163.277 1.00 77.56  ?  515  GLU   C CD    1 
ATOM   2848 O OE1   . GLU   A 1 515  ? 91.659  150.069 164.142 1.00 73.49  ?  515  GLU   C OE1   1 
ATOM   2849 O OE2   . GLU   A 1 515  ? 93.029  148.629 163.382 1.00 86.18  -1 515  GLU   C OE2   1 
ATOM   2850 N N     . LYS   A 1 516  ? 90.470  152.412 163.353 1.00 79.42  ?  516  LYS   C N     1 
ATOM   2851 C CA    . LYS   A 1 516  ? 90.428  153.772 163.892 1.00 77.29  ?  516  LYS   C CA    1 
ATOM   2852 C C     . LYS   A 1 516  ? 91.687  154.201 164.661 1.00 73.34  ?  516  LYS   C C     1 
ATOM   2853 O O     . LYS   A 1 516  ? 91.759  154.042 165.879 1.00 68.74  ?  516  LYS   C O     1 
ATOM   2854 C CB    . LYS   A 1 516  ? 89.210  153.928 164.806 1.00 73.62  ?  516  LYS   C CB    1 
ATOM   2855 C CG    . LYS   A 1 516  ? 87.866  153.745 164.102 1.00 79.04  ?  516  LYS   C CG    1 
ATOM   2856 C CD    . LYS   A 1 516  ? 86.688  153.978 165.047 1.00 85.09  ?  516  LYS   C CD    1 
ATOM   2857 C CE    . LYS   A 1 516  ? 86.454  152.779 165.961 1.00 74.94  ?  516  LYS   C CE    1 
ATOM   2858 N NZ    . LYS   A 1 516  ? 85.193  152.912 166.730 1.00 87.23  1  516  LYS   C NZ    1 
ATOM   2859 N N     . PHE   A 1 517  ? 92.653  154.777 163.945 1.00 67.31  ?  517  PHE   C N     1 
ATOM   2860 C CA    . PHE   A 1 517  ? 93.876  155.336 164.535 1.00 60.74  ?  517  PHE   C CA    1 
ATOM   2861 C C     . PHE   A 1 517  ? 94.179  156.655 163.873 1.00 61.26  ?  517  PHE   C C     1 
ATOM   2862 O O     . PHE   A 1 517  ? 93.526  157.012 162.903 1.00 61.28  ?  517  PHE   C O     1 
ATOM   2863 C CB    . PHE   A 1 517  ? 95.098  154.427 164.357 1.00 56.15  ?  517  PHE   C CB    1 
ATOM   2864 C CG    . PHE   A 1 517  ? 95.103  153.212 165.179 1.00 62.59  ?  517  PHE   C CG    1 
ATOM   2865 C CD1   . PHE   A 1 517  ? 94.677  152.008 164.673 1.00 69.94  ?  517  PHE   C CD1   1 
ATOM   2866 C CD2   . PHE   A 1 517  ? 95.555  153.269 166.484 1.00 56.77  ?  517  PHE   C CD2   1 
ATOM   2867 C CE1   . PHE   A 1 517  ? 94.697  150.880 165.456 1.00 72.72  ?  517  PHE   C CE1   1 
ATOM   2868 C CE2   . PHE   A 1 517  ? 95.575  152.150 167.265 1.00 51.96  ?  517  PHE   C CE2   1 
ATOM   2869 C CZ    . PHE   A 1 517  ? 95.144  150.951 166.751 1.00 71.71  ?  517  PHE   C CZ    1 
ATOM   2870 N N     . TYR   A 1 518  ? 95.189  157.359 164.360 1.00 56.98  ?  518  TYR   C N     1 
ATOM   2871 C CA    . TYR   A 1 518  ? 95.629  158.569 163.684 1.00 53.02  ?  518  TYR   C CA    1 
ATOM   2872 C C     . TYR   A 1 518  ? 97.122  158.543 163.428 1.00 49.54  ?  518  TYR   C C     1 
ATOM   2873 O O     . TYR   A 1 518  ? 97.900  158.083 164.263 1.00 48.92  ?  518  TYR   C O     1 
ATOM   2874 C CB    . TYR   A 1 518  ? 95.255  159.808 164.491 1.00 56.15  ?  518  TYR   C CB    1 
ATOM   2875 C CG    . TYR   A 1 518  ? 93.776  160.009 164.613 1.00 62.32  ?  518  TYR   C CG    1 
ATOM   2876 C CD1   . TYR   A 1 518  ? 93.085  159.408 165.651 1.00 66.23  ?  518  TYR   C CD1   1 
ATOM   2877 C CD2   . TYR   A 1 518  ? 93.107  160.796 163.693 1.00 60.72  ?  518  TYR   C CD2   1 
ATOM   2878 C CE1   . TYR   A 1 518  ? 91.728  159.597 165.770 1.00 71.22  ?  518  TYR   C CE1   1 
ATOM   2879 C CE2   . TYR   A 1 518  ? 91.751  160.986 163.811 1.00 66.28  ?  518  TYR   C CE2   1 
ATOM   2880 C CZ    . TYR   A 1 518  ? 91.060  160.392 164.846 1.00 74.49  ?  518  TYR   C CZ    1 
ATOM   2881 O OH    . TYR   A 1 518  ? 89.702  160.585 164.967 1.00 72.77  ?  518  TYR   C OH    1 
ATOM   2882 N N     . SER   A 1 519  ? 97.527  159.062 162.283 1.00 47.03  ?  519  SER   C N     1 
ATOM   2883 C CA    . SER   A 1 519  ? 98.942  159.177 161.961 1.00 39.12  ?  519  SER   C CA    1 
ATOM   2884 C C     . SER   A 1 519  ? 99.179  160.271 160.941 1.00 36.03  ?  519  SER   C C     1 
ATOM   2885 O O     . SER   A 1 519  ? 98.239  160.777 160.328 1.00 40.38  ?  519  SER   C O     1 
ATOM   2886 C CB    . SER   A 1 519  ? 99.475  157.860 161.447 1.00 36.82  ?  519  SER   C CB    1 
ATOM   2887 O OG    . SER   A 1 519  ? 98.880  157.517 160.232 1.00 44.28  ?  519  SER   C OG    1 
ATOM   2888 N N     . PHE   A 1 520  ? 100.437 160.639 160.761 1.00 32.12  ?  520  PHE   C N     1 
ATOM   2889 C CA    . PHE   A 1 520  ? 100.801 161.671 159.802 1.00 29.06  ?  520  PHE   C CA    1 
ATOM   2890 C C     . PHE   A 1 520  ? 100.743 161.133 158.382 1.00 29.30  ?  520  PHE   C C     1 
ATOM   2891 O O     . PHE   A 1 520  ? 100.963 159.944 158.147 1.00 30.60  ?  520  PHE   C O     1 
ATOM   2892 C CB    . PHE   A 1 520  ? 102.197 162.210 160.104 1.00 23.43  ?  520  PHE   C CB    1 
ATOM   2893 C CG    . PHE   A 1 520  ? 102.258 163.084 161.326 1.00 22.64  ?  520  PHE   C CG    1 
ATOM   2894 C CD1   . PHE   A 1 520  ? 102.626 162.567 162.555 1.00 22.34  ?  520  PHE   C CD1   1 
ATOM   2895 C CD2   . PHE   A 1 520  ? 101.953 164.429 161.242 1.00 23.67  ?  520  PHE   C CD2   1 
ATOM   2896 C CE1   . PHE   A 1 520  ? 102.685 163.376 163.668 1.00 22.67  ?  520  PHE   C CE1   1 
ATOM   2897 C CE2   . PHE   A 1 520  ? 102.014 165.236 162.352 1.00 22.54  ?  520  PHE   C CE2   1 
ATOM   2898 C CZ    . PHE   A 1 520  ? 102.379 164.710 163.565 1.00 23.62  ?  520  PHE   C CZ    1 
ATOM   2899 N N     . ILE   A 1 521  ? 100.480 162.023 157.426 1.00 29.10  ?  521  ILE   C N     1 
ATOM   2900 C CA    . ILE   A 1 521  ? 100.380 161.627 156.022 1.00 27.56  ?  521  ILE   C CA    1 
ATOM   2901 C C     . ILE   A 1 521  ? 101.666 161.001 155.490 1.00 26.01  ?  521  ILE   C C     1 
ATOM   2902 O O     . ILE   A 1 521  ? 101.629 160.214 154.544 1.00 30.86  ?  521  ILE   C O     1 
ATOM   2903 C CB    . ILE   A 1 521  ? 99.989  162.830 155.137 1.00 32.54  ?  521  ILE   C CB    1 
ATOM   2904 C CG1   . ILE   A 1 521  ? 101.032 163.946 155.246 1.00 27.47  ?  521  ILE   C CG1   1 
ATOM   2905 C CG2   . ILE   A 1 521  ? 98.630  163.332 155.548 1.00 42.91  ?  521  ILE   C CG2   1 
ATOM   2906 C CD1   . ILE   A 1 521  ? 100.869 165.032 154.211 1.00 30.06  ?  521  ILE   C CD1   1 
ATOM   2907 N N     . HIS   A 1 522  ? 102.793 161.331 156.096 1.00 22.08  ?  522  HIS   C N     1 
ATOM   2908 C CA    . HIS   A 1 522  ? 104.057 160.725 155.707 1.00 16.03  ?  522  HIS   C CA    1 
ATOM   2909 C C     . HIS   A 1 522  ? 105.053 160.819 156.844 1.00 15.25  ?  522  HIS   C C     1 
ATOM   2910 O O     . HIS   A 1 522  ? 105.036 161.779 157.615 1.00 17.21  ?  522  HIS   C O     1 
ATOM   2911 C CB    . HIS   A 1 522  ? 104.637 161.381 154.457 1.00 16.14  ?  522  HIS   C CB    1 
ATOM   2912 C CG    . HIS   A 1 522  ? 105.587 160.494 153.748 1.00 13.30  ?  522  HIS   C CG    1 
ATOM   2913 N ND1   . HIS   A 1 522  ? 106.906 160.354 154.121 1.00 13.29  ?  522  HIS   C ND1   1 
ATOM   2914 C CD2   . HIS   A 1 522  ? 105.405 159.674 152.691 1.00 13.11  ?  522  HIS   C CD2   1 
ATOM   2915 C CE1   . HIS   A 1 522  ? 107.491 159.484 153.317 1.00 10.98  ?  522  HIS   C CE1   1 
ATOM   2916 N NE2   . HIS   A 1 522  ? 106.599 159.058 152.445 1.00 10.77  ?  522  HIS   C NE2   1 
ATOM   2917 N N     . MET   A 1 523  ? 105.959 159.851 156.921 1.00 15.60  ?  523  MET   C N     1 
ATOM   2918 C CA    . MET   A 1 523  ? 106.973 159.860 157.961 1.00 13.97  ?  523  MET   C CA    1 
ATOM   2919 C C     . MET   A 1 523  ? 107.809 161.131 157.922 1.00 14.96  ?  523  MET   C C     1 
ATOM   2920 O O     . MET   A 1 523  ? 108.265 161.596 158.967 1.00 18.32  ?  523  MET   C O     1 
ATOM   2921 C CB    . MET   A 1 523  ? 107.874 158.640 157.825 1.00 15.48  ?  523  MET   C CB    1 
ATOM   2922 C CG    . MET   A 1 523  ? 108.743 158.376 159.038 1.00 23.55  ?  523  MET   C CG    1 
ATOM   2923 S SD    . MET   A 1 523  ? 107.767 157.920 160.485 1.00 40.56  ?  523  MET   C SD    1 
ATOM   2924 C CE    . MET   A 1 523  ? 108.644 158.765 161.789 1.00 24.93  ?  523  MET   C CE    1 
ATOM   2925 N N     . THR   A 1 524  ? 107.999 161.713 156.738 1.00 15.19  ?  524  THR   C N     1 
ATOM   2926 C CA    . THR   A 1 524  ? 108.783 162.938 156.646 1.00 12.90  ?  524  THR   C CA    1 
ATOM   2927 C C     . THR   A 1 524  ? 108.086 164.103 157.329 1.00 13.36  ?  524  THR   C C     1 
ATOM   2928 O O     . THR   A 1 524  ? 108.746 165.012 157.832 1.00 14.63  ?  524  THR   C O     1 
ATOM   2929 C CB    . THR   A 1 524  ? 109.063 163.332 155.191 1.00 12.02  ?  524  THR   C CB    1 
ATOM   2930 O OG1   . THR   A 1 524  ? 107.820 163.470 154.501 1.00 13.83  ?  524  THR   C OG1   1 
ATOM   2931 C CG2   . THR   A 1 524  ? 109.929 162.298 154.503 1.00 12.14  ?  524  THR   C CG2   1 
ATOM   2932 N N     . PHE   A 1 525  ? 106.758 164.089 157.356 1.00 15.07  ?  525  PHE   C N     1 
ATOM   2933 C CA    . PHE   A 1 525  ? 106.022 165.157 158.011 1.00 14.30  ?  525  PHE   C CA    1 
ATOM   2934 C C     . PHE   A 1 525  ? 106.107 165.003 159.512 1.00 15.64  ?  525  PHE   C C     1 
ATOM   2935 O O     . PHE   A 1 525  ? 106.247 165.988 160.236 1.00 17.56  ?  525  PHE   C O     1 
ATOM   2936 C CB    . PHE   A 1 525  ? 104.574 165.204 157.540 1.00 15.24  ?  525  PHE   C CB    1 
ATOM   2937 C CG    . PHE   A 1 525  ? 104.411 165.986 156.275 1.00 15.08  ?  525  PHE   C CG    1 
ATOM   2938 C CD1   . PHE   A 1 525  ? 104.382 165.365 155.041 1.00 16.16  ?  525  PHE   C CD1   1 
ATOM   2939 C CD2   . PHE   A 1 525  ? 104.295 167.364 156.325 1.00 16.76  ?  525  PHE   C CD2   1 
ATOM   2940 C CE1   . PHE   A 1 525  ? 104.241 166.105 153.884 1.00 16.32  ?  525  PHE   C CE1   1 
ATOM   2941 C CE2   . PHE   A 1 525  ? 104.155 168.100 155.178 1.00 18.60  ?  525  PHE   C CE2   1 
ATOM   2942 C CZ    . PHE   A 1 525  ? 104.126 167.472 153.955 1.00 18.24  ?  525  PHE   C CZ    1 
ATOM   2943 N N     . GLN   A 1 526  ? 106.061 163.764 159.984 1.00 15.64  ?  526  GLN   C N     1 
ATOM   2944 C CA    . GLN   A 1 526  ? 106.213 163.541 161.409 1.00 15.61  ?  526  GLN   C CA    1 
ATOM   2945 C C     . GLN   A 1 526  ? 107.580 164.025 161.858 1.00 16.43  ?  526  GLN   C C     1 
ATOM   2946 O O     . GLN   A 1 526  ? 107.702 164.720 162.866 1.00 19.71  ?  526  GLN   C O     1 
ATOM   2947 C CB    . GLN   A 1 526  ? 106.041 162.065 161.760 1.00 18.28  ?  526  GLN   C CB    1 
ATOM   2948 C CG    . GLN   A 1 526  ? 106.129 161.780 163.248 1.00 17.94  ?  526  GLN   C CG    1 
ATOM   2949 C CD    . GLN   A 1 526  ? 105.762 160.364 163.595 1.00 23.59  ?  526  GLN   C CD    1 
ATOM   2950 O OE1   . GLN   A 1 526  ? 105.403 159.566 162.729 1.00 31.89  ?  526  GLN   C OE1   1 
ATOM   2951 N NE2   . GLN   A 1 526  ? 105.840 160.048 164.878 1.00 26.93  ?  526  GLN   C NE2   1 
ATOM   2952 N N     . GLU   A 1 527  ? 108.607 163.692 161.081 1.00 17.11  ?  527  GLU   C N     1 
ATOM   2953 C CA    . GLU   A 1 527  ? 109.964 164.114 161.390 1.00 14.45  ?  527  GLU   C CA    1 
ATOM   2954 C C     . GLU   A 1 527  ? 110.113 165.628 161.301 1.00 14.37  ?  527  GLU   C C     1 
ATOM   2955 O O     . GLU   A 1 527  ? 110.817 166.231 162.109 1.00 16.52  ?  527  GLU   C O     1 
ATOM   2956 C CB    . GLU   A 1 527  ? 110.961 163.400 160.480 1.00 12.94  ?  527  GLU   C CB    1 
ATOM   2957 C CG    . GLU   A 1 527  ? 111.107 161.915 160.810 1.00 16.97  ?  527  GLU   C CG    1 
ATOM   2958 C CD    . GLU   A 1 527  ? 112.078 161.175 159.943 1.00 18.49  ?  527  GLU   C CD    1 
ATOM   2959 O OE1   . GLU   A 1 527  ? 111.967 161.254 158.747 1.00 18.38  ?  527  GLU   C OE1   1 
ATOM   2960 O OE2   . GLU   A 1 527  ? 112.946 160.531 160.482 1.00 20.43  -1 527  GLU   C OE2   1 
ATOM   2961 N N     . PHE   A 1 528  ? 109.429 166.250 160.344 1.00 14.99  ?  528  PHE   C N     1 
ATOM   2962 C CA    . PHE   A 1 528  ? 109.467 167.700 160.226 1.00 14.27  ?  528  PHE   C CA    1 
ATOM   2963 C C     . PHE   A 1 528  ? 109.016 168.354 161.513 1.00 16.78  ?  528  PHE   C C     1 
ATOM   2964 O O     . PHE   A 1 528  ? 109.700 169.224 162.058 1.00 19.28  ?  528  PHE   C O     1 
ATOM   2965 C CB    . PHE   A 1 528  ? 108.550 168.180 159.106 1.00 13.76  ?  528  PHE   C CB    1 
ATOM   2966 C CG    . PHE   A 1 528  ? 108.465 169.662 159.020 1.00 14.08  ?  528  PHE   C CG    1 
ATOM   2967 C CD1   . PHE   A 1 528  ? 109.362 170.364 158.261 1.00 13.53  ?  528  PHE   C CD1   1 
ATOM   2968 C CD2   . PHE   A 1 528  ? 107.496 170.361 159.713 1.00 20.02  ?  528  PHE   C CD2   1 
ATOM   2969 C CE1   . PHE   A 1 528  ? 109.307 171.726 158.180 1.00 16.25  ?  528  PHE   C CE1   1 
ATOM   2970 C CE2   . PHE   A 1 528  ? 107.439 171.726 159.640 1.00 21.45  ?  528  PHE   C CE2   1 
ATOM   2971 C CZ    . PHE   A 1 528  ? 108.346 172.409 158.871 1.00 18.94  ?  528  PHE   C CZ    1 
ATOM   2972 N N     . PHE   A 1 529  ? 107.863 167.932 162.006 1.00 18.61  ?  529  PHE   C N     1 
ATOM   2973 C CA    . PHE   A 1 529  ? 107.297 168.501 163.211 1.00 19.95  ?  529  PHE   C CA    1 
ATOM   2974 C C     . PHE   A 1 529  ? 108.165 168.199 164.422 1.00 20.67  ?  529  PHE   C C     1 
ATOM   2975 O O     . PHE   A 1 529  ? 108.368 169.049 165.281 1.00 22.53  ?  529  PHE   C O     1 
ATOM   2976 C CB    . PHE   A 1 529  ? 105.888 167.975 163.422 1.00 20.68  ?  529  PHE   C CB    1 
ATOM   2977 C CG    . PHE   A 1 529  ? 104.884 168.631 162.558 1.00 21.03  ?  529  PHE   C CG    1 
ATOM   2978 C CD1   . PHE   A 1 529  ? 104.237 167.925 161.572 1.00 19.64  ?  529  PHE   C CD1   1 
ATOM   2979 C CD2   . PHE   A 1 529  ? 104.585 169.965 162.725 1.00 23.16  ?  529  PHE   C CD2   1 
ATOM   2980 C CE1   . PHE   A 1 529  ? 103.311 168.532 160.769 1.00 22.86  ?  529  PHE   C CE1   1 
ATOM   2981 C CE2   . PHE   A 1 529  ? 103.662 170.577 161.929 1.00 22.60  ?  529  PHE   C CE2   1 
ATOM   2982 C CZ    . PHE   A 1 529  ? 103.022 169.858 160.950 1.00 25.10  ?  529  PHE   C CZ    1 
ATOM   2983 N N     . ALA   A 1 530  ? 108.698 166.978 164.456 1.00 18.86  ?  530  ALA   C N     1 
ATOM   2984 C CA    . ALA   A 1 530  ? 109.564 166.586 165.565 1.00 18.78  ?  530  ALA   C CA    1 
ATOM   2985 C C     . ALA   A 1 530  ? 110.783 167.478 165.606 1.00 19.88  ?  530  ALA   C C     1 
ATOM   2986 O O     . ALA   A 1 530  ? 111.290 167.784 166.707 1.00 24.12  ?  530  ALA   C O     1 
ATOM   2987 C CB    . ALA   A 1 530  ? 109.989 165.136 165.383 1.00 19.64  ?  530  ALA   C CB    1 
ATOM   2988 N N     . ALA   A 1 531  ? 111.287 167.917 164.475 1.00 21.24  ?  531  ALA   C N     1 
ATOM   2989 C CA    . ALA   A 1 531  ? 112.411 168.818 164.413 1.00 19.69  ?  531  ALA   C CA    1 
ATOM   2990 C C     . ALA   A 1 531  ? 112.026 170.207 164.909 1.00 20.73  ?  531  ALA   C C     1 
ATOM   2991 O O     . ALA   A 1 531  ? 112.713 170.823 165.700 1.00 24.61  ?  531  ALA   C O     1 
ATOM   2992 C CB    . ALA   A 1 531  ? 112.979 168.902 163.018 1.00 16.46  ?  531  ALA   C CB    1 
ATOM   2993 N N     . MET   A 1 532  ? 110.858 170.669 164.442 1.00 21.55  ?  532  MET   C N     1 
ATOM   2994 C CA    . MET   A 1 532  ? 110.384 172.002 164.802 1.00 23.68  ?  532  MET   C CA    1 
ATOM   2995 C C     . MET   A 1 532  ? 110.142 172.110 166.290 1.00 26.73  ?  532  MET   C C     1 
ATOM   2996 O O     . MET   A 1 532  ? 110.353 173.167 166.883 1.00 28.85  ?  532  MET   C O     1 
ATOM   2997 C CB    . MET   A 1 532  ? 109.121 172.336 164.022 1.00 24.85  ?  532  MET   C CB    1 
ATOM   2998 C CG    . MET   A 1 532  ? 108.634 173.748 164.234 1.00 30.61  ?  532  MET   C CG    1 
ATOM   2999 S SD    . MET   A 1 532  ? 107.298 174.205 163.124 1.00 39.14  ?  532  MET   C SD    1 
ATOM   3000 C CE    . MET   A 1 532  ? 108.209 174.759 161.686 1.00 29.74  ?  532  MET   C CE    1 
ATOM   3001 N N     . TYR   A 1 533  ? 109.751 171.010 166.908 1.00 25.72  ?  533  TYR   C N     1 
ATOM   3002 C CA    . TYR   A 1 533  ? 109.550 170.957 168.345 1.00 26.37  ?  533  TYR   C CA    1 
ATOM   3003 C C     . TYR   A 1 533  ? 110.715 171.573 169.110 1.00 28.57  ?  533  TYR   C C     1 
ATOM   3004 O O     . TYR   A 1 533  ? 110.516 172.307 170.076 1.00 33.89  ?  533  TYR   C O     1 
ATOM   3005 C CB    . TYR   A 1 533  ? 109.343 169.514 168.784 1.00 26.36  ?  533  TYR   C CB    1 
ATOM   3006 C CG    . TYR   A 1 533  ? 109.338 169.304 170.252 1.00 29.70  ?  533  TYR   C CG    1 
ATOM   3007 C CD1   . TYR   A 1 533  ? 108.256 169.695 171.021 1.00 33.91  ?  533  TYR   C CD1   1 
ATOM   3008 C CD2   . TYR   A 1 533  ? 110.427 168.693 170.837 1.00 30.34  ?  533  TYR   C CD2   1 
ATOM   3009 C CE1   . TYR   A 1 533  ? 108.273 169.472 172.378 1.00 36.76  ?  533  TYR   C CE1   1 
ATOM   3010 C CE2   . TYR   A 1 533  ? 110.444 168.466 172.183 1.00 36.95  ?  533  TYR   C CE2   1 
ATOM   3011 C CZ    . TYR   A 1 533  ? 109.375 168.852 172.955 1.00 38.68  ?  533  TYR   C CZ    1 
ATOM   3012 O OH    . TYR   A 1 533  ? 109.393 168.629 174.301 1.00 42.58  ?  533  TYR   C OH    1 
ATOM   3013 N N     . TYR   A 1 534  ? 111.936 171.271 168.688 1.00 27.15  ?  534  TYR   C N     1 
ATOM   3014 C CA    . TYR   A 1 534  ? 113.120 171.707 169.413 1.00 25.21  ?  534  TYR   C CA    1 
ATOM   3015 C C     . TYR   A 1 534  ? 113.302 173.216 169.362 1.00 26.99  ?  534  TYR   C C     1 
ATOM   3016 O O     . TYR   A 1 534  ? 114.031 173.782 170.172 1.00 32.13  ?  534  TYR   C O     1 
ATOM   3017 C CB    . TYR   A 1 534  ? 114.362 171.020 168.844 1.00 25.32  ?  534  TYR   C CB    1 
ATOM   3018 C CG    . TYR   A 1 534  ? 114.444 169.566 169.190 1.00 24.51  ?  534  TYR   C CG    1 
ATOM   3019 C CD1   . TYR   A 1 534  ? 113.806 168.638 168.399 1.00 23.42  ?  534  TYR   C CD1   1 
ATOM   3020 C CD2   . TYR   A 1 534  ? 115.157 169.157 170.298 1.00 28.51  ?  534  TYR   C CD2   1 
ATOM   3021 C CE1   . TYR   A 1 534  ? 113.863 167.304 168.720 1.00 25.75  ?  534  TYR   C CE1   1 
ATOM   3022 C CE2   . TYR   A 1 534  ? 115.220 167.821 170.620 1.00 30.26  ?  534  TYR   C CE2   1 
ATOM   3023 C CZ    . TYR   A 1 534  ? 114.573 166.898 169.840 1.00 31.69  ?  534  TYR   C CZ    1 
ATOM   3024 O OH    . TYR   A 1 534  ? 114.625 165.567 170.173 1.00 37.71  ?  534  TYR   C OH    1 
ATOM   3025 N N     . LEU   A 1 535  ? 112.691 173.858 168.376 1.00 28.24  ?  535  LEU   C N     1 
ATOM   3026 C CA    . LEU   A 1 535  ? 112.887 175.279 168.149 1.00 31.73  ?  535  LEU   C CA    1 
ATOM   3027 C C     . LEU   A 1 535  ? 111.734 176.145 168.658 1.00 37.68  ?  535  LEU   C C     1 
ATOM   3028 O O     . LEU   A 1 535  ? 111.786 177.372 168.553 1.00 40.27  ?  535  LEU   C O     1 
ATOM   3029 C CB    . LEU   A 1 535  ? 113.079 175.510 166.647 1.00 32.33  ?  535  LEU   C CB    1 
ATOM   3030 C CG    . LEU   A 1 535  ? 114.229 174.726 165.983 1.00 31.71  ?  535  LEU   C CG    1 
ATOM   3031 C CD1   . LEU   A 1 535  ? 114.208 174.988 164.491 1.00 28.93  ?  535  LEU   C CD1   1 
ATOM   3032 C CD2   . LEU   A 1 535  ? 115.560 175.138 166.588 1.00 35.47  ?  535  LEU   C CD2   1 
ATOM   3033 N N     . LEU   A 1 536  ? 110.688 175.524 169.192 1.00 37.10  ?  536  LEU   C N     1 
ATOM   3034 C CA    . LEU   A 1 536  ? 109.512 176.283 169.607 1.00 38.37  ?  536  LEU   C CA    1 
ATOM   3035 C C     . LEU   A 1 536  ? 109.736 177.030 170.912 1.00 43.68  ?  536  LEU   C C     1 
ATOM   3036 O O     . LEU   A 1 536  ? 110.427 176.533 171.804 1.00 42.20  ?  536  LEU   C O     1 
ATOM   3037 C CB    . LEU   A 1 536  ? 108.304 175.356 169.792 1.00 39.07  ?  536  LEU   C CB    1 
ATOM   3038 C CG    . LEU   A 1 536  ? 107.740 174.690 168.550 1.00 36.53  ?  536  LEU   C CG    1 
ATOM   3039 C CD1   . LEU   A 1 536  ? 106.758 173.645 168.974 1.00 37.14  ?  536  LEU   C CD1   1 
ATOM   3040 C CD2   . LEU   A 1 536  ? 107.035 175.717 167.683 1.00 39.69  ?  536  LEU   C CD2   1 
ATOM   3041 N N     . GLU   A 1 537  ? 109.087 178.201 171.045 1.00 46.57  ?  537  GLU   C N     1 
ATOM   3042 C CA    . GLU   A 1 537  ? 109.027 178.973 172.297 1.00 47.11  ?  537  GLU   C CA    1 
ATOM   3043 C C     . GLU   A 1 537  ? 110.412 179.439 172.724 1.00 49.45  ?  537  GLU   C C     1 
ATOM   3044 O O     . GLU   A 1 537  ? 110.598 180.590 173.126 1.00 57.27  ?  537  GLU   C O     1 
ATOM   3045 C CB    . GLU   A 1 537  ? 108.379 178.155 173.449 1.00 46.33  ?  537  GLU   C CB    1 
ATOM   3046 C CG    . GLU   A 1 537  ? 106.878 177.751 173.250 1.00 55.11  ?  537  GLU   C CG    1 
ATOM   3047 C CD    . GLU   A 1 537  ? 105.897 178.916 173.300 1.00 67.28  ?  537  GLU   C CD    1 
ATOM   3048 O OE1   . GLU   A 1 537  ? 106.029 179.751 174.164 1.00 57.06  ?  537  GLU   C OE1   1 
ATOM   3049 O OE2   . GLU   A 1 537  ? 105.017 178.957 172.473 1.00 73.98  -1 537  GLU   C OE2   1 
ATOM   3050 N N     . LEU   A 1 553  ? 107.236 165.393 176.911 1.00 37.47  ?  553  LEU   C N     1 
ATOM   3051 C CA    . LEU   A 1 553  ? 108.334 166.313 176.643 1.00 43.90  ?  553  LEU   C CA    1 
ATOM   3052 C C     . LEU   A 1 553  ? 109.679 165.562 176.773 1.00 50.31  ?  553  LEU   C C     1 
ATOM   3053 O O     . LEU   A 1 553  ? 110.353 165.684 177.801 1.00 54.43  ?  553  LEU   C O     1 
ATOM   3054 C CB    . LEU   A 1 553  ? 108.271 167.524 177.612 1.00 44.98  ?  553  LEU   C CB    1 
ATOM   3055 C CG    . LEU   A 1 553  ? 106.938 168.397 177.577 1.00 62.51  ?  553  LEU   C CG    1 
ATOM   3056 C CD1   . LEU   A 1 553  ? 107.007 169.483 178.683 1.00 55.28  ?  553  LEU   C CD1   1 
ATOM   3057 C CD2   . LEU   A 1 553  ? 106.753 169.054 176.176 1.00 49.13  ?  553  LEU   C CD2   1 
ATOM   3058 N N     . PRO   A 1 554  ? 110.086 164.762 175.745 1.00 46.47  ?  554  PRO   C N     1 
ATOM   3059 C CA    . PRO   A 1 554  ? 111.249 163.876 175.719 1.00 46.64  ?  554  PRO   C CA    1 
ATOM   3060 C C     . PRO   A 1 554  ? 112.578 164.488 176.166 1.00 47.28  ?  554  PRO   C C     1 
ATOM   3061 O O     . PRO   A 1 554  ? 113.355 163.823 176.848 1.00 50.17  ?  554  PRO   C O     1 
ATOM   3062 C CB    . PRO   A 1 554  ? 111.323 163.489 174.236 1.00 46.67  ?  554  PRO   C CB    1 
ATOM   3063 C CG    . PRO   A 1 554  ? 109.896 163.533 173.767 1.00 45.79  ?  554  PRO   C CG    1 
ATOM   3064 C CD    . PRO   A 1 554  ? 109.310 164.725 174.459 1.00 44.42  ?  554  PRO   C CD    1 
ATOM   3065 N N     . SER   A 1 555  ? 112.854 165.732 175.775 1.00 45.13  ?  555  SER   C N     1 
ATOM   3066 C CA    . SER   A 1 555  ? 114.141 166.332 176.135 1.00 44.62  ?  555  SER   C CA    1 
ATOM   3067 C C     . SER   A 1 555  ? 114.259 167.805 175.759 1.00 43.34  ?  555  SER   C C     1 
ATOM   3068 O O     . SER   A 1 555  ? 114.556 168.651 176.600 1.00 43.01  ?  555  SER   C O     1 
ATOM   3069 C CB    . SER   A 1 555  ? 115.267 165.603 175.438 1.00 44.02  ?  555  SER   C CB    1 
ATOM   3070 O OG    . SER   A 1 555  ? 115.259 165.898 174.068 1.00 43.47  ?  555  SER   C OG    1 
ATOM   3071 N N     . ARG   A 1 556  ? 114.095 168.080 174.465 1.00 39.88  ?  556  ARG   C N     1 
ATOM   3072 C CA    . ARG   A 1 556  ? 114.353 169.390 173.852 1.00 39.20  ?  556  ARG   C CA    1 
ATOM   3073 C C     . ARG   A 1 556  ? 115.852 169.687 173.830 1.00 39.76  ?  556  ARG   C C     1 
ATOM   3074 O O     . ARG   A 1 556  ? 116.272 170.826 173.630 1.00 40.25  ?  556  ARG   C O     1 
ATOM   3075 C CB    . ARG   A 1 556  ? 113.623 170.523 174.565 1.00 40.66  ?  556  ARG   C CB    1 
ATOM   3076 C CG    . ARG   A 1 556  ? 112.126 170.399 174.572 1.00 42.60  ?  556  ARG   C CG    1 
ATOM   3077 C CD    . ARG   A 1 556  ? 111.463 171.595 175.126 1.00 47.12  ?  556  ARG   C CD    1 
ATOM   3078 N NE    . ARG   A 1 556  ? 111.609 172.750 174.240 1.00 44.96  ?  556  ARG   C NE    1 
ATOM   3079 C CZ    . ARG   A 1 556  ? 111.356 174.030 174.581 1.00 50.82  ?  556  ARG   C CZ    1 
ATOM   3080 N NH1   . ARG   A 1 556  ? 110.939 174.329 175.794 1.00 56.51  1  556  ARG   C NH1   1 
ATOM   3081 N NH2   . ARG   A 1 556  ? 111.525 174.987 173.689 1.00 43.35  ?  556  ARG   C NH2   1 
ATOM   3082 N N     . ASP   A 1 557  ? 116.652 168.641 174.007 1.00 40.64  ?  557  ASP   C N     1 
ATOM   3083 C CA    . ASP   A 1 557  ? 118.104 168.741 173.967 1.00 39.50  ?  557  ASP   C CA    1 
ATOM   3084 C C     . ASP   A 1 557  ? 118.662 168.202 172.658 1.00 38.80  ?  557  ASP   C C     1 
ATOM   3085 O O     . ASP   A 1 557  ? 118.642 166.997 172.406 1.00 38.91  ?  557  ASP   C O     1 
ATOM   3086 C CB    . ASP   A 1 557  ? 118.743 167.996 175.134 1.00 42.53  ?  557  ASP   C CB    1 
ATOM   3087 C CG    . ASP   A 1 557  ? 120.259 168.153 175.149 1.00 44.94  ?  557  ASP   C CG    1 
ATOM   3088 O OD1   . ASP   A 1 557  ? 120.774 168.861 174.301 1.00 41.83  ?  557  ASP   C OD1   1 
ATOM   3089 O OD2   . ASP   A 1 557  ? 120.892 167.559 175.987 1.00 45.22  -1 557  ASP   C OD2   1 
ATOM   3090 N N     . VAL   A 1 558  ? 119.155 169.092 171.818 1.00 37.42  ?  558  VAL   C N     1 
ATOM   3091 C CA    . VAL   A 1 558  ? 119.659 168.683 170.521 1.00 33.85  ?  558  VAL   C CA    1 
ATOM   3092 C C     . VAL   A 1 558  ? 120.858 167.751 170.652 1.00 33.83  ?  558  VAL   C C     1 
ATOM   3093 O O     . VAL   A 1 558  ? 121.164 167.002 169.726 1.00 34.13  ?  558  VAL   C O     1 
ATOM   3094 C CB    . VAL   A 1 558  ? 120.035 169.912 169.683 1.00 36.61  ?  558  VAL   C CB    1 
ATOM   3095 C CG1   . VAL   A 1 558  ? 121.337 170.525 170.178 1.00 40.22  ?  558  VAL   C CG1   1 
ATOM   3096 C CG2   . VAL   A 1 558  ? 120.150 169.525 168.214 1.00 35.57  ?  558  VAL   C CG2   1 
ATOM   3097 N N     . THR   A 1 559  ? 121.557 167.807 171.783 1.00 35.57  ?  559  THR   C N     1 
ATOM   3098 C CA    . THR   A 1 559  ? 122.736 166.972 171.939 1.00 35.25  ?  559  THR   C CA    1 
ATOM   3099 C C     . THR   A 1 559  ? 122.365 165.498 171.937 1.00 37.62  ?  559  THR   C C     1 
ATOM   3100 O O     . THR   A 1 559  ? 122.958 164.707 171.203 1.00 35.16  ?  559  THR   C O     1 
ATOM   3101 C CB    . THR   A 1 559  ? 123.495 167.305 173.234 1.00 39.43  ?  559  THR   C CB    1 
ATOM   3102 O OG1   . THR   A 1 559  ? 123.928 168.666 173.199 1.00 42.40  ?  559  THR   C OG1   1 
ATOM   3103 C CG2   . THR   A 1 559  ? 124.710 166.402 173.370 1.00 42.67  ?  559  THR   C CG2   1 
ATOM   3104 N N     . VAL   A 1 560  ? 121.366 165.122 172.733 1.00 36.61  ?  560  VAL   C N     1 
ATOM   3105 C CA    . VAL   A 1 560  ? 120.969 163.723 172.788 1.00 38.02  ?  560  VAL   C CA    1 
ATOM   3106 C C     . VAL   A 1 560  ? 120.337 163.307 171.471 1.00 36.71  ?  560  VAL   C C     1 
ATOM   3107 O O     . VAL   A 1 560  ? 120.451 162.158 171.050 1.00 36.26  ?  560  VAL   C O     1 
ATOM   3108 C CB    . VAL   A 1 560  ? 120.020 163.436 173.974 1.00 39.70  ?  560  VAL   C CB    1 
ATOM   3109 C CG1   . VAL   A 1 560  ? 118.629 163.998 173.729 1.00 42.22  ?  560  VAL   C CG1   1 
ATOM   3110 C CG2   . VAL   A 1 560  ? 119.947 161.932 174.190 1.00 44.27  ?  560  VAL   C CG2   1 
ATOM   3111 N N     . LEU   A 1 561  ? 119.682 164.250 170.804 1.00 35.16  ?  561  LEU   C N     1 
ATOM   3112 C CA    . LEU   A 1 561  ? 119.103 163.950 169.507 1.00 33.48  ?  561  LEU   C CA    1 
ATOM   3113 C C     . LEU   A 1 561  ? 120.188 163.537 168.522 1.00 30.18  ?  561  LEU   C C     1 
ATOM   3114 O O     . LEU   A 1 561  ? 120.085 162.499 167.865 1.00 30.60  ?  561  LEU   C O     1 
ATOM   3115 C CB    . LEU   A 1 561  ? 118.376 165.189 168.967 1.00 34.47  ?  561  LEU   C CB    1 
ATOM   3116 C CG    . LEU   A 1 561  ? 117.741 165.056 167.588 1.00 32.37  ?  561  LEU   C CG    1 
ATOM   3117 C CD1   . LEU   A 1 561  ? 116.577 164.073 167.651 1.00 33.19  ?  561  LEU   C CD1   1 
ATOM   3118 C CD2   . LEU   A 1 561  ? 117.296 166.426 167.125 1.00 29.50  ?  561  LEU   C CD2   1 
ATOM   3119 N N     . LEU   A 1 562  ? 121.246 164.331 168.439 1.00 30.48  ?  562  LEU   C N     1 
ATOM   3120 C CA    . LEU   A 1 562  ? 122.332 164.073 167.504 1.00 27.12  ?  562  LEU   C CA    1 
ATOM   3121 C C     . LEU   A 1 562  ? 123.077 162.782 167.826 1.00 28.21  ?  562  LEU   C C     1 
ATOM   3122 O O     . LEU   A 1 562  ? 123.516 162.068 166.923 1.00 30.75  ?  562  LEU   C O     1 
ATOM   3123 C CB    . LEU   A 1 562  ? 123.296 165.261 167.503 1.00 27.17  ?  562  LEU   C CB    1 
ATOM   3124 C CG    . LEU   A 1 562  ? 122.733 166.580 166.918 1.00 27.05  ?  562  LEU   C CG    1 
ATOM   3125 C CD1   . LEU   A 1 562  ? 123.699 167.711 167.224 1.00 26.73  ?  562  LEU   C CD1   1 
ATOM   3126 C CD2   . LEU   A 1 562  ? 122.532 166.442 165.410 1.00 22.49  ?  562  LEU   C CD2   1 
ATOM   3127 N N     . GLU   A 1 563  ? 123.185 162.456 169.109 1.00 31.23  ?  563  GLU   C N     1 
ATOM   3128 C CA    . GLU   A 1 563  ? 123.872 161.244 169.550 1.00 29.75  ?  563  GLU   C CA    1 
ATOM   3129 C C     . GLU   A 1 563  ? 123.211 159.968 169.036 1.00 30.12  ?  563  GLU   C C     1 
ATOM   3130 O O     . GLU   A 1 563  ? 123.839 158.909 169.007 1.00 30.79  ?  563  GLU   C O     1 
ATOM   3131 C CB    . GLU   A 1 563  ? 123.938 161.189 171.076 1.00 35.82  ?  563  GLU   C CB    1 
ATOM   3132 C CG    . GLU   A 1 563  ? 124.922 162.162 171.709 1.00 44.83  ?  563  GLU   C CG    1 
ATOM   3133 C CD    . GLU   A 1 563  ? 124.844 162.168 173.214 1.00 49.39  ?  563  GLU   C CD    1 
ATOM   3134 O OE1   . GLU   A 1 563  ? 124.018 161.465 173.748 1.00 47.31  ?  563  GLU   C OE1   1 
ATOM   3135 O OE2   . GLU   A 1 563  ? 125.610 162.872 173.829 1.00 49.08  -1 563  GLU   C OE2   1 
ATOM   3136 N N     . ASN   A 1 564  ? 121.938 160.055 168.667 1.00 31.58  ?  564  ASN   C N     1 
ATOM   3137 C CA    . ASN   A 1 564  ? 121.185 158.897 168.207 1.00 29.15  ?  564  ASN   C CA    1 
ATOM   3138 C C     . ASN   A 1 564  ? 120.980 158.907 166.693 1.00 26.92  ?  564  ASN   C C     1 
ATOM   3139 O O     . ASN   A 1 564  ? 120.201 158.120 166.156 1.00 25.96  ?  564  ASN   C O     1 
ATOM   3140 C CB    . ASN   A 1 564  ? 119.853 158.848 168.926 1.00 29.60  ?  564  ASN   C CB    1 
ATOM   3141 C CG    . ASN   A 1 564  ? 119.979 158.435 170.371 1.00 33.55  ?  564  ASN   C CG    1 
ATOM   3142 O OD1   . ASN   A 1 564  ? 119.952 157.237 170.679 1.00 32.87  ?  564  ASN   C OD1   1 
ATOM   3143 N ND2   . ASN   A 1 564  ? 120.124 159.379 171.266 1.00 34.98  ?  564  ASN   C ND2   1 
ATOM   3144 N N     . TYR   A 1 565  ? 121.684 159.797 166.005 1.00 24.41  ?  565  TYR   C N     1 
ATOM   3145 C CA    . TYR   A 1 565  ? 121.506 159.995 164.569 1.00 20.59  ?  565  TYR   C CA    1 
ATOM   3146 C C     . TYR   A 1 565  ? 121.662 158.732 163.732 1.00 19.08  ?  565  TYR   C C     1 
ATOM   3147 O O     . TYR   A 1 565  ? 120.885 158.481 162.822 1.00 19.75  ?  565  TYR   C O     1 
ATOM   3148 C CB    . TYR   A 1 565  ? 122.484 161.051 164.072 1.00 20.45  ?  565  TYR   C CB    1 
ATOM   3149 C CG    . TYR   A 1 565  ? 122.349 161.355 162.615 1.00 17.80  ?  565  TYR   C CG    1 
ATOM   3150 C CD1   . TYR   A 1 565  ? 121.329 162.170 162.186 1.00 15.99  ?  565  TYR   C CD1   1 
ATOM   3151 C CD2   . TYR   A 1 565  ? 123.245 160.829 161.703 1.00 19.05  ?  565  TYR   C CD2   1 
ATOM   3152 C CE1   . TYR   A 1 565  ? 121.200 162.467 160.859 1.00 16.42  ?  565  TYR   C CE1   1 
ATOM   3153 C CE2   . TYR   A 1 565  ? 123.109 161.126 160.372 1.00 16.68  ?  565  TYR   C CE2   1 
ATOM   3154 C CZ    . TYR   A 1 565  ? 122.093 161.946 159.952 1.00 14.52  ?  565  TYR   C CZ    1 
ATOM   3155 O OH    . TYR   A 1 565  ? 121.961 162.253 158.624 1.00 19.49  ?  565  TYR   C OH    1 
ATOM   3156 N N     . GLY   A 1 566  ? 122.684 157.947 163.990 1.00 19.07  ?  566  GLY   C N     1 
ATOM   3157 C CA    . GLY   A 1 566  ? 122.937 156.807 163.118 1.00 21.76  ?  566  GLY   C CA    1 
ATOM   3158 C C     . GLY   A 1 566  ? 122.208 155.547 163.561 1.00 23.54  ?  566  GLY   C C     1 
ATOM   3159 O O     . GLY   A 1 566  ? 122.454 154.466 163.025 1.00 22.33  ?  566  GLY   C O     1 
ATOM   3160 N N     . LYS   A 1 567  ? 121.343 155.666 164.562 1.00 24.96  ?  567  LYS   C N     1 
ATOM   3161 C CA    . LYS   A 1 567  ? 120.712 154.488 165.129 1.00 22.74  ?  567  LYS   C CA    1 
ATOM   3162 C C     . LYS   A 1 567  ? 119.349 154.161 164.526 1.00 21.38  ?  567  LYS   C C     1 
ATOM   3163 O O     . LYS   A 1 567  ? 118.443 154.997 164.484 1.00 21.08  ?  567  LYS   C O     1 
ATOM   3164 C CB    . LYS   A 1 567  ? 120.584 154.657 166.640 1.00 27.92  ?  567  LYS   C CB    1 
ATOM   3165 C CG    . LYS   A 1 567  ? 121.917 154.755 167.363 1.00 28.39  ?  567  LYS   C CG    1 
ATOM   3166 C CD    . LYS   A 1 567  ? 121.722 154.836 168.863 1.00 38.92  ?  567  LYS   C CD    1 
ATOM   3167 C CE    . LYS   A 1 567  ? 123.048 155.007 169.597 1.00 46.07  ?  567  LYS   C CE    1 
ATOM   3168 N NZ    . LYS   A 1 567  ? 122.859 155.056 171.074 1.00 37.57  1  567  LYS   C NZ    1 
ATOM   3169 N N     . PHE   A 1 568  ? 119.197 152.897 164.143 1.00 21.01  ?  568  PHE   C N     1 
ATOM   3170 C CA    . PHE   A 1 568  ? 117.943 152.335 163.653 1.00 20.65  ?  568  PHE   C CA    1 
ATOM   3171 C C     . PHE   A 1 568  ? 116.839 152.544 164.668 1.00 22.88  ?  568  PHE   C C     1 
ATOM   3172 O O     . PHE   A 1 568  ? 115.707 152.878 164.323 1.00 23.58  ?  568  PHE   C O     1 
ATOM   3173 C CB    . PHE   A 1 568  ? 118.106 150.838 163.410 1.00 22.79  ?  568  PHE   C CB    1 
ATOM   3174 C CG    . PHE   A 1 568  ? 116.869 150.119 162.922 1.00 24.83  ?  568  PHE   C CG    1 
ATOM   3175 C CD1   . PHE   A 1 568  ? 116.608 149.962 161.563 1.00 24.77  ?  568  PHE   C CD1   1 
ATOM   3176 C CD2   . PHE   A 1 568  ? 115.964 149.589 163.826 1.00 28.76  ?  568  PHE   C CD2   1 
ATOM   3177 C CE1   . PHE   A 1 568  ? 115.482 149.293 161.132 1.00 24.43  ?  568  PHE   C CE1   1 
ATOM   3178 C CE2   . PHE   A 1 568  ? 114.840 148.926 163.397 1.00 28.65  ?  568  PHE   C CE2   1 
ATOM   3179 C CZ    . PHE   A 1 568  ? 114.598 148.774 162.046 1.00 27.21  ?  568  PHE   C CZ    1 
ATOM   3180 N N     . GLU   A 1 569  ? 117.187 152.331 165.930 1.00 26.48  ?  569  GLU   C N     1 
ATOM   3181 C CA    . GLU   A 1 569  ? 116.266 152.375 167.053 1.00 26.04  ?  569  GLU   C CA    1 
ATOM   3182 C C     . GLU   A 1 569  ? 115.475 153.672 167.154 1.00 24.64  ?  569  GLU   C C     1 
ATOM   3183 O O     . GLU   A 1 569  ? 114.417 153.697 167.778 1.00 28.52  ?  569  GLU   C O     1 
ATOM   3184 C CB    . GLU   A 1 569  ? 117.047 152.165 168.350 1.00 28.67  ?  569  GLU   C CB    1 
ATOM   3185 C CG    . GLU   A 1 569  ? 117.645 150.771 168.516 1.00 37.14  ?  569  GLU   C CG    1 
ATOM   3186 C CD    . GLU   A 1 569  ? 118.978 150.572 167.840 1.00 34.83  ?  569  GLU   C CD    1 
ATOM   3187 O OE1   . GLU   A 1 569  ? 119.341 151.375 167.018 1.00 31.06  ?  569  GLU   C OE1   1 
ATOM   3188 O OE2   . GLU   A 1 569  ? 119.628 149.601 168.143 1.00 45.81  -1 569  GLU   C OE2   1 
ATOM   3189 N N     . LYS   A 1 570  ? 115.998 154.758 166.593 1.00 24.86  ?  570  LYS   C N     1 
ATOM   3190 C CA    . LYS   A 1 570  ? 115.302 156.037 166.658 1.00 24.94  ?  570  LYS   C CA    1 
ATOM   3191 C C     . LYS   A 1 570  ? 114.838 156.481 165.277 1.00 23.31  ?  570  LYS   C C     1 
ATOM   3192 O O     . LYS   A 1 570  ? 114.399 157.616 165.093 1.00 25.15  ?  570  LYS   C O     1 
ATOM   3193 C CB    . LYS   A 1 570  ? 116.184 157.097 167.313 1.00 26.25  ?  570  LYS   C CB    1 
ATOM   3194 C CG    . LYS   A 1 570  ? 116.595 156.765 168.753 1.00 29.65  ?  570  LYS   C CG    1 
ATOM   3195 C CD    . LYS   A 1 570  ? 115.388 156.675 169.681 1.00 32.22  ?  570  LYS   C CD    1 
ATOM   3196 C CE    . LYS   A 1 570  ? 115.802 156.491 171.132 1.00 35.35  ?  570  LYS   C CE    1 
ATOM   3197 N NZ    . LYS   A 1 570  ? 116.374 155.145 171.383 1.00 35.90  1  570  LYS   C NZ    1 
ATOM   3198 N N     . GLY   A 1 571  ? 114.942 155.581 164.303 1.00 21.35  ?  571  GLY   C N     1 
ATOM   3199 C CA    . GLY   A 1 571  ? 114.519 155.858 162.937 1.00 17.49  ?  571  GLY   C CA    1 
ATOM   3200 C C     . GLY   A 1 571  ? 115.550 156.648 162.147 1.00 19.30  ?  571  GLY   C C     1 
ATOM   3201 O O     . GLY   A 1 571  ? 115.209 157.288 161.153 1.00 22.70  ?  571  GLY   C O     1 
ATOM   3202 N N     . TYR   A 1 572  ? 116.798 156.632 162.608 1.00 19.10  ?  572  TYR   C N     1 
ATOM   3203 C CA    . TYR   A 1 572  ? 117.915 157.338 161.985 1.00 14.93  ?  572  TYR   C CA    1 
ATOM   3204 C C     . TYR   A 1 572  ? 117.832 158.866 162.072 1.00 14.47  ?  572  TYR   C C     1 
ATOM   3205 O O     . TYR   A 1 572  ? 118.836 159.551 161.924 1.00 18.41  ?  572  TYR   C O     1 
ATOM   3206 C CB    . TYR   A 1 572  ? 118.083 156.887 160.542 1.00 14.93  ?  572  TYR   C CB    1 
ATOM   3207 C CG    . TYR   A 1 572  ? 118.344 155.416 160.407 1.00 14.86  ?  572  TYR   C CG    1 
ATOM   3208 C CD1   . TYR   A 1 572  ? 117.356 154.557 159.972 1.00 14.85  ?  572  TYR   C CD1   1 
ATOM   3209 C CD2   . TYR   A 1 572  ? 119.592 154.933 160.715 1.00 17.31  ?  572  TYR   C CD2   1 
ATOM   3210 C CE1   . TYR   A 1 572  ? 117.628 153.216 159.841 1.00 14.09  ?  572  TYR   C CE1   1 
ATOM   3211 C CE2   . TYR   A 1 572  ? 119.863 153.603 160.585 1.00 17.09  ?  572  TYR   C CE2   1 
ATOM   3212 C CZ    . TYR   A 1 572  ? 118.894 152.748 160.150 1.00 14.90  ?  572  TYR   C CZ    1 
ATOM   3213 O OH    . TYR   A 1 572  ? 119.182 151.424 160.019 1.00 19.60  ?  572  TYR   C OH    1 
ATOM   3214 N N     . LEU   A 1 573  ? 116.651 159.417 162.289 1.00 14.65  ?  573  LEU   C N     1 
ATOM   3215 C CA    . LEU   A 1 573  ? 116.531 160.855 162.495 1.00 15.07  ?  573  LEU   C CA    1 
ATOM   3216 C C     . LEU   A 1 573  ? 117.152 161.659 161.364 1.00 14.15  ?  573  LEU   C C     1 
ATOM   3217 O O     . LEU   A 1 573  ? 117.627 162.777 161.577 1.00 14.80  ?  573  LEU   C O     1 
ATOM   3218 C CB    . LEU   A 1 573  ? 117.244 161.243 163.795 1.00 18.73  ?  573  LEU   C CB    1 
ATOM   3219 C CG    . LEU   A 1 573  ? 116.841 160.478 165.041 1.00 20.20  ?  573  LEU   C CG    1 
ATOM   3220 C CD1   . LEU   A 1 573  ? 117.783 160.851 166.165 1.00 24.16  ?  573  LEU   C CD1   1 
ATOM   3221 C CD2   . LEU   A 1 573  ? 115.418 160.818 165.398 1.00 19.15  ?  573  LEU   C CD2   1 
ATOM   3222 N N     . ILE   A 1 574  ? 117.165 161.105 160.161 1.00 14.65  ?  574  ILE   C N     1 
ATOM   3223 C CA    . ILE   A 1 574  ? 117.824 161.769 159.054 1.00 12.02  ?  574  ILE   C CA    1 
ATOM   3224 C C     . ILE   A 1 574  ? 117.119 163.046 158.684 1.00 12.05  ?  574  ILE   C C     1 
ATOM   3225 O O     . ILE   A 1 574  ? 117.754 164.079 158.487 1.00 13.67  ?  574  ILE   C O     1 
ATOM   3226 C CB    . ILE   A 1 574  ? 117.939 160.837 157.848 1.00 11.43  ?  574  ILE   C CB    1 
ATOM   3227 C CG1   . ILE   A 1 574  ? 118.930 159.737 158.194 1.00 11.31  ?  574  ILE   C CG1   1 
ATOM   3228 C CG2   . ILE   A 1 574  ? 118.376 161.613 156.609 1.00 10.51  ?  574  ILE   C CG2   1 
ATOM   3229 C CD1   . ILE   A 1 574  ? 118.895 158.559 157.275 1.00 15.77  ?  574  ILE   C CD1   1 
ATOM   3230 N N     . PHE   A 1 575  ? 115.803 162.981 158.594 1.00 12.78  ?  575  PHE   C N     1 
ATOM   3231 C CA    . PHE   A 1 575  ? 115.046 164.160 158.246 1.00 11.75  ?  575  PHE   C CA    1 
ATOM   3232 C C     . PHE   A 1 575  ? 114.875 165.078 159.436 1.00 12.43  ?  575  PHE   C C     1 
ATOM   3233 O O     . PHE   A 1 575  ? 114.766 166.288 159.276 1.00 13.05  ?  575  PHE   C O     1 
ATOM   3234 C CB    . PHE   A 1 575  ? 113.710 163.776 157.650 1.00 12.08  ?  575  PHE   C CB    1 
ATOM   3235 C CG    . PHE   A 1 575  ? 113.848 163.269 156.264 1.00 11.53  ?  575  PHE   C CG    1 
ATOM   3236 C CD1   . PHE   A 1 575  ? 113.945 161.918 156.010 1.00 11.77  ?  575  PHE   C CD1   1 
ATOM   3237 C CD2   . PHE   A 1 575  ? 113.894 164.148 155.205 1.00 11.06  ?  575  PHE   C CD2   1 
ATOM   3238 C CE1   . PHE   A 1 575  ? 114.084 161.460 154.725 1.00 11.33  ?  575  PHE   C CE1   1 
ATOM   3239 C CE2   . PHE   A 1 575  ? 114.031 163.691 153.921 1.00 10.71  ?  575  PHE   C CE2   1 
ATOM   3240 C CZ    . PHE   A 1 575  ? 114.128 162.344 153.681 1.00 9.36   ?  575  PHE   C CZ    1 
ATOM   3241 N N     . VAL   A 1 576  ? 114.892 164.527 160.641 1.00 13.37  ?  576  VAL   C N     1 
ATOM   3242 C CA    . VAL   A 1 576  ? 114.739 165.382 161.805 1.00 13.47  ?  576  VAL   C CA    1 
ATOM   3243 C C     . VAL   A 1 576  ? 115.903 166.359 161.864 1.00 13.82  ?  576  VAL   C C     1 
ATOM   3244 O O     . VAL   A 1 576  ? 115.710 167.560 162.053 1.00 14.26  ?  576  VAL   C O     1 
ATOM   3245 C CB    . VAL   A 1 576  ? 114.692 164.553 163.102 1.00 15.40  ?  576  VAL   C CB    1 
ATOM   3246 C CG1   . VAL   A 1 576  ? 114.711 165.472 164.309 1.00 17.29  ?  576  VAL   C CG1   1 
ATOM   3247 C CG2   . VAL   A 1 576  ? 113.447 163.699 163.119 1.00 14.79  ?  576  VAL   C CG2   1 
ATOM   3248 N N     . VAL   A 1 577  ? 117.114 165.849 161.683 1.00 14.01  ?  577  VAL   C N     1 
ATOM   3249 C CA    . VAL   A 1 577  ? 118.287 166.704 161.700 1.00 12.61  ?  577  VAL   C CA    1 
ATOM   3250 C C     . VAL   A 1 577  ? 118.359 167.566 160.450 1.00 13.89  ?  577  VAL   C C     1 
ATOM   3251 O O     . VAL   A 1 577  ? 118.645 168.760 160.529 1.00 15.96  ?  577  VAL   C O     1 
ATOM   3252 C CB    . VAL   A 1 577  ? 119.564 165.872 161.872 1.00 13.92  ?  577  VAL   C CB    1 
ATOM   3253 C CG1   . VAL   A 1 577  ? 120.795 166.749 161.697 1.00 15.99  ?  577  VAL   C CG1   1 
ATOM   3254 C CG2   . VAL   A 1 577  ? 119.555 165.249 163.266 1.00 18.26  ?  577  VAL   C CG2   1 
ATOM   3255 N N     . ARG   A 1 578  ? 118.091 166.974 159.293 1.00 13.17  ?  578  ARG   C N     1 
ATOM   3256 C CA    . ARG   A 1 578  ? 118.124 167.727 158.051 1.00 10.90  ?  578  ARG   C CA    1 
ATOM   3257 C C     . ARG   A 1 578  ? 117.173 168.922 158.114 1.00 11.37  ?  578  ARG   C C     1 
ATOM   3258 O O     . ARG   A 1 578  ? 117.519 170.020 157.675 1.00 14.45  ?  578  ARG   C O     1 
ATOM   3259 C CB    . ARG   A 1 578  ? 117.763 166.826 156.878 1.00 11.94  ?  578  ARG   C CB    1 
ATOM   3260 C CG    . ARG   A 1 578  ? 117.926 167.450 155.523 1.00 11.32  ?  578  ARG   C CG    1 
ATOM   3261 C CD    . ARG   A 1 578  ? 117.518 166.543 154.413 1.00 10.91  ?  578  ARG   C CD    1 
ATOM   3262 N NE    . ARG   A 1 578  ? 118.403 165.395 154.254 1.00 7.83   ?  578  ARG   C NE    1 
ATOM   3263 C CZ    . ARG   A 1 578  ? 118.213 164.411 153.347 1.00 7.15   ?  578  ARG   C CZ    1 
ATOM   3264 N NH1   . ARG   A 1 578  ? 117.180 164.457 152.538 1.00 8.53   1  578  ARG   C NH1   1 
ATOM   3265 N NH2   . ARG   A 1 578  ? 119.060 163.401 153.258 1.00 10.43  ?  578  ARG   C NH2   1 
ATOM   3266 N N     . PHE   A 1 579  ? 115.989 168.726 158.693 1.00 13.83  ?  579  PHE   C N     1 
ATOM   3267 C CA    . PHE   A 1 579  ? 115.038 169.820 158.836 1.00 12.87  ?  579  PHE   C CA    1 
ATOM   3268 C C     . PHE   A 1 579  ? 115.509 170.854 159.853 1.00 14.80  ?  579  PHE   C C     1 
ATOM   3269 O O     . PHE   A 1 579  ? 115.281 172.046 159.660 1.00 16.90  ?  579  PHE   C O     1 
ATOM   3270 C CB    . PHE   A 1 579  ? 113.646 169.313 159.217 1.00 12.55  ?  579  PHE   C CB    1 
ATOM   3271 C CG    . PHE   A 1 579  ? 112.847 168.754 158.060 1.00 11.58  ?  579  PHE   C CG    1 
ATOM   3272 C CD1   . PHE   A 1 579  ? 112.349 167.467 158.093 1.00 11.77  ?  579  PHE   C CD1   1 
ATOM   3273 C CD2   . PHE   A 1 579  ? 112.587 169.524 156.942 1.00 12.88  ?  579  PHE   C CD2   1 
ATOM   3274 C CE1   . PHE   A 1 579  ? 111.616 166.966 157.042 1.00 10.63  ?  579  PHE   C CE1   1 
ATOM   3275 C CE2   . PHE   A 1 579  ? 111.858 169.023 155.891 1.00 11.84  ?  579  PHE   C CE2   1 
ATOM   3276 C CZ    . PHE   A 1 579  ? 111.373 167.745 155.943 1.00 11.20  ?  579  PHE   C CZ    1 
ATOM   3277 N N     . LEU   A 1 580  ? 116.200 170.426 160.911 1.00 14.78  ?  580  LEU   C N     1 
ATOM   3278 C CA    . LEU   A 1 580  ? 116.720 171.413 161.856 1.00 14.88  ?  580  LEU   C CA    1 
ATOM   3279 C C     . LEU   A 1 580  ? 117.677 172.351 161.154 1.00 17.35  ?  580  LEU   C C     1 
ATOM   3280 O O     . LEU   A 1 580  ? 117.650 173.557 161.390 1.00 21.15  ?  580  LEU   C O     1 
ATOM   3281 C CB    . LEU   A 1 580  ? 117.461 170.755 163.027 1.00 15.44  ?  580  LEU   C CB    1 
ATOM   3282 C CG    . LEU   A 1 580  ? 116.614 170.053 164.080 1.00 17.19  ?  580  LEU   C CG    1 
ATOM   3283 C CD1   . LEU   A 1 580  ? 117.524 169.283 165.012 1.00 16.50  ?  580  LEU   C CD1   1 
ATOM   3284 C CD2   . LEU   A 1 580  ? 115.804 171.090 164.868 1.00 21.30  ?  580  LEU   C CD2   1 
ATOM   3285 N N     . PHE   A 1 581  ? 118.503 171.828 160.262 1.00 15.62  ?  581  PHE   C N     1 
ATOM   3286 C CA    . PHE   A 1 581  ? 119.410 172.700 159.535 1.00 14.71  ?  581  PHE   C CA    1 
ATOM   3287 C C     . PHE   A 1 581  ? 118.632 173.743 158.746 1.00 15.94  ?  581  PHE   C C     1 
ATOM   3288 O O     . PHE   A 1 581  ? 118.968 174.923 158.762 1.00 20.69  ?  581  PHE   C O     1 
ATOM   3289 C CB    . PHE   A 1 581  ? 120.298 171.898 158.589 1.00 12.76  ?  581  PHE   C CB    1 
ATOM   3290 C CG    . PHE   A 1 581  ? 121.523 171.341 159.218 1.00 11.01  ?  581  PHE   C CG    1 
ATOM   3291 C CD1   . PHE   A 1 581  ? 121.540 170.075 159.751 1.00 11.33  ?  581  PHE   C CD1   1 
ATOM   3292 C CD2   . PHE   A 1 581  ? 122.675 172.087 159.260 1.00 12.73  ?  581  PHE   C CD2   1 
ATOM   3293 C CE1   . PHE   A 1 581  ? 122.683 169.565 160.316 1.00 12.32  ?  581  PHE   C CE1   1 
ATOM   3294 C CE2   . PHE   A 1 581  ? 123.810 171.588 159.822 1.00 14.58  ?  581  PHE   C CE2   1 
ATOM   3295 C CZ    . PHE   A 1 581  ? 123.819 170.322 160.352 1.00 13.70  ?  581  PHE   C CZ    1 
ATOM   3296 N N     . GLY   A 1 582  ? 117.576 173.306 158.070 1.00 16.03  ?  582  GLY   C N     1 
ATOM   3297 C CA    . GLY   A 1 582  ? 116.754 174.214 157.273 1.00 16.46  ?  582  GLY   C CA    1 
ATOM   3298 C C     . GLY   A 1 582  ? 115.995 175.235 158.116 1.00 19.49  ?  582  GLY   C C     1 
ATOM   3299 O O     . GLY   A 1 582  ? 115.866 176.395 157.721 1.00 23.65  ?  582  GLY   C O     1 
ATOM   3300 N N     . LEU   A 1 583  ? 115.468 174.800 159.257 1.00 20.92  ?  583  LEU   C N     1 
ATOM   3301 C CA    . LEU   A 1 583  ? 114.684 175.673 160.125 1.00 19.97  ?  583  LEU   C CA    1 
ATOM   3302 C C     . LEU   A 1 583  ? 115.570 176.645 160.894 1.00 21.76  ?  583  LEU   C C     1 
ATOM   3303 O O     . LEU   A 1 583  ? 115.205 177.803 161.104 1.00 29.08  ?  583  LEU   C O     1 
ATOM   3304 C CB    . LEU   A 1 583  ? 113.859 174.834 161.105 1.00 20.45  ?  583  LEU   C CB    1 
ATOM   3305 C CG    . LEU   A 1 583  ? 112.728 173.971 160.498 1.00 18.96  ?  583  LEU   C CG    1 
ATOM   3306 C CD1   . LEU   A 1 583  ? 112.195 173.023 161.564 1.00 18.79  ?  583  LEU   C CD1   1 
ATOM   3307 C CD2   . LEU   A 1 583  ? 111.614 174.868 159.992 1.00 19.70  ?  583  LEU   C CD2   1 
ATOM   3308 N N     . VAL   A 1 584  ? 116.750 176.195 161.290 1.00 22.54  ?  584  VAL   C N     1 
ATOM   3309 C CA    . VAL   A 1 584  ? 117.677 177.060 162.001 1.00 23.20  ?  584  VAL   C CA    1 
ATOM   3310 C C     . VAL   A 1 584  ? 118.427 177.919 161.003 1.00 29.62  ?  584  VAL   C C     1 
ATOM   3311 O O     . VAL   A 1 584  ? 119.582 177.657 160.670 1.00 35.54  ?  584  VAL   C O     1 
ATOM   3312 C CB    . VAL   A 1 584  ? 118.656 176.216 162.838 1.00 24.07  ?  584  VAL   C CB    1 
ATOM   3313 C CG1   . VAL   A 1 584  ? 119.628 177.093 163.596 1.00 33.82  ?  584  VAL   C CG1   1 
ATOM   3314 C CG2   . VAL   A 1 584  ? 117.870 175.393 163.826 1.00 27.13  ?  584  VAL   C CG2   1 
ATOM   3315 N N     . ASN   A 1 585  ? 117.749 178.951 160.527 1.00 31.86  ?  585  ASN   C N     1 
ATOM   3316 C CA    . ASN   A 1 585  ? 118.269 179.820 159.484 1.00 40.27  ?  585  ASN   C CA    1 
ATOM   3317 C C     . ASN   A 1 585  ? 117.785 181.245 159.690 1.00 49.36  ?  585  ASN   C C     1 
ATOM   3318 O O     . ASN   A 1 585  ? 116.606 181.480 159.951 1.00 50.82  ?  585  ASN   C O     1 
ATOM   3319 C CB    . ASN   A 1 585  ? 117.876 179.300 158.111 1.00 35.97  ?  585  ASN   C CB    1 
ATOM   3320 C CG    . ASN   A 1 585  ? 118.486 180.088 156.971 1.00 41.75  ?  585  ASN   C CG    1 
ATOM   3321 O OD1   . ASN   A 1 585  ? 119.153 181.109 157.184 1.00 49.64  ?  585  ASN   C OD1   1 
ATOM   3322 N ND2   . ASN   A 1 585  ? 118.261 179.636 155.764 1.00 38.09  ?  585  ASN   C ND2   1 
ATOM   3323 N N     . GLN   A 1 586  ? 118.703 182.197 159.574 1.00 51.63  ?  586  GLN   C N     1 
ATOM   3324 C CA    . GLN   A 1 586  ? 118.366 183.606 159.716 1.00 57.63  ?  586  GLN   C CA    1 
ATOM   3325 C C     . GLN   A 1 586  ? 117.385 184.039 158.636 1.00 58.38  ?  586  GLN   C C     1 
ATOM   3326 O O     . GLN   A 1 586  ? 116.538 184.907 158.859 1.00 63.77  ?  586  GLN   C O     1 
ATOM   3327 C CB    . GLN   A 1 586  ? 119.628 184.468 159.647 1.00 63.63  ?  586  GLN   C CB    1 
ATOM   3328 C CG    . GLN   A 1 586  ? 119.391 185.938 159.946 1.00 69.53  ?  586  GLN   C CG    1 
ATOM   3329 C CD    . GLN   A 1 586  ? 118.908 186.159 161.364 1.00 71.96  ?  586  GLN   C CD    1 
ATOM   3330 O OE1   . GLN   A 1 586  ? 119.514 185.664 162.319 1.00 64.67  ?  586  GLN   C OE1   1 
ATOM   3331 N NE2   . GLN   A 1 586  ? 117.816 186.901 161.512 1.00 68.54  ?  586  GLN   C NE2   1 
ATOM   3332 N N     . GLU   A 1 587  ? 117.494 183.433 157.460 1.00 58.02  ?  587  GLU   C N     1 
ATOM   3333 C CA    . GLU   A 1 587  ? 116.615 183.778 156.353 1.00 61.90  ?  587  GLU   C CA    1 
ATOM   3334 C C     . GLU   A 1 587  ? 115.269 183.087 156.528 1.00 60.64  ?  587  GLU   C C     1 
ATOM   3335 O O     . GLU   A 1 587  ? 114.953 182.118 155.838 1.00 60.55  ?  587  GLU   C O     1 
ATOM   3336 C CB    . GLU   A 1 587  ? 117.249 183.377 155.019 1.00 60.95  ?  587  GLU   C CB    1 
ATOM   3337 C CG    . GLU   A 1 587  ? 118.550 184.103 154.701 1.00 60.91  ?  587  GLU   C CG    1 
ATOM   3338 C CD    . GLU   A 1 587  ? 119.143 183.694 153.380 1.00 75.46  ?  587  GLU   C CD    1 
ATOM   3339 O OE1   . GLU   A 1 587  ? 118.619 182.795 152.766 1.00 59.61  ?  587  GLU   C OE1   1 
ATOM   3340 O OE2   . GLU   A 1 587  ? 120.121 184.284 152.985 1.00 67.52  -1 587  GLU   C OE2   1 
ATOM   3341 N N     . ARG   A 1 588  ? 114.490 183.604 157.469 1.00 63.16  ?  588  ARG   C N     1 
ATOM   3342 C CA    . ARG   A 1 588  ? 113.197 183.043 157.835 1.00 69.94  ?  588  ARG   C CA    1 
ATOM   3343 C C     . ARG   A 1 588  ? 112.076 184.025 157.532 1.00 70.94  ?  588  ARG   C C     1 
ATOM   3344 O O     . ARG   A 1 588  ? 112.318 185.222 157.371 1.00 72.21  ?  588  ARG   C O     1 
ATOM   3345 C CB    . ARG   A 1 588  ? 113.171 182.684 159.312 1.00 69.26  ?  588  ARG   C CB    1 
ATOM   3346 C CG    . ARG   A 1 588  ? 113.319 183.850 160.263 1.00 72.41  ?  588  ARG   C CG    1 
ATOM   3347 C CD    . ARG   A 1 588  ? 113.178 183.414 161.671 1.00 76.78  ?  588  ARG   C CD    1 
ATOM   3348 N NE    . ARG   A 1 588  ? 113.371 184.516 162.599 1.00 82.00  ?  588  ARG   C NE    1 
ATOM   3349 C CZ    . ARG   A 1 588  ? 112.408 185.380 162.982 1.00 80.17  ?  588  ARG   C CZ    1 
ATOM   3350 N NH1   . ARG   A 1 588  ? 111.186 185.265 162.512 1.00 69.86  1  588  ARG   C NH1   1 
ATOM   3351 N NH2   . ARG   A 1 588  ? 112.695 186.349 163.832 1.00 83.00  ?  588  ARG   C NH2   1 
ATOM   3352 N N     . THR   A 1 589  ? 110.849 183.519 157.461 1.00 70.82  ?  589  THR   C N     1 
ATOM   3353 C CA    . THR   A 1 589  ? 109.689 184.360 157.187 1.00 73.75  ?  589  THR   C CA    1 
ATOM   3354 C C     . THR   A 1 589  ? 108.612 184.217 158.258 1.00 72.12  ?  589  THR   C C     1 
ATOM   3355 O O     . THR   A 1 589  ? 108.874 183.734 159.359 1.00 68.81  ?  589  THR   C O     1 
ATOM   3356 C CB    . THR   A 1 589  ? 109.104 184.060 155.788 1.00 72.02  ?  589  THR   C CB    1 
ATOM   3357 O OG1   . THR   A 1 589  ? 108.094 185.035 155.474 1.00 66.89  ?  589  THR   C OG1   1 
ATOM   3358 C CG2   . THR   A 1 589  ? 108.508 182.657 155.726 1.00 67.13  ?  589  THR   C CG2   1 
ATOM   3359 N N     . SER   A 1 590  ? 107.416 184.700 157.944 1.00 74.25  ?  590  SER   C N     1 
ATOM   3360 C CA    . SER   A 1 590  ? 106.289 184.670 158.866 1.00 73.72  ?  590  SER   C CA    1 
ATOM   3361 C C     . SER   A 1 590  ? 105.499 183.383 158.731 1.00 75.30  ?  590  SER   C C     1 
ATOM   3362 O O     . SER   A 1 590  ? 105.925 182.452 158.054 1.00 70.80  ?  590  SER   C O     1 
ATOM   3363 C CB    . SER   A 1 590  ? 105.364 185.843 158.614 1.00 77.44  ?  590  SER   C CB    1 
ATOM   3364 O OG    . SER   A 1 590  ? 104.303 185.849 159.534 1.00 76.03  ?  590  SER   C OG    1 
ATOM   3365 N N     . TYR   A 1 591  ? 104.354 183.331 159.400 1.00 81.13  ?  591  TYR   C N     1 
ATOM   3366 C CA    . TYR   A 1 591  ? 103.459 182.179 159.349 1.00 76.43  ?  591  TYR   C CA    1 
ATOM   3367 C C     . TYR   A 1 591  ? 104.076 180.938 159.975 1.00 73.50  ?  591  TYR   C C     1 
ATOM   3368 O O     . TYR   A 1 591  ? 104.775 180.178 159.306 1.00 70.61  ?  591  TYR   C O     1 
ATOM   3369 C CB    . TYR   A 1 591  ? 103.054 181.874 157.909 1.00 75.94  ?  591  TYR   C CB    1 
ATOM   3370 C CG    . TYR   A 1 591  ? 102.484 183.058 157.180 1.00 78.37  ?  591  TYR   C CG    1 
ATOM   3371 C CD1   . TYR   A 1 591  ? 103.249 183.721 156.231 1.00 76.66  ?  591  TYR   C CD1   1 
ATOM   3372 C CD2   . TYR   A 1 591  ? 101.205 183.489 157.461 1.00 82.53  ?  591  TYR   C CD2   1 
ATOM   3373 C CE1   . TYR   A 1 591  ? 102.731 184.811 155.566 1.00 85.85  ?  591  TYR   C CE1   1 
ATOM   3374 C CE2   . TYR   A 1 591  ? 100.683 184.581 156.797 1.00 90.46  ?  591  TYR   C CE2   1 
ATOM   3375 C CZ    . TYR   A 1 591  ? 101.443 185.241 155.851 1.00 87.21  ?  591  TYR   C CZ    1 
ATOM   3376 O OH    . TYR   A 1 591  ? 100.925 186.328 155.188 1.00 84.50  ?  591  TYR   C OH    1 
ATOM   3377 N N     . LEU   A 1 592  ? 103.815 180.739 161.264 1.00 71.85  ?  592  LEU   C N     1 
ATOM   3378 C CA    . LEU   A 1 592  ? 104.293 179.579 162.028 1.00 72.62  ?  592  LEU   C CA    1 
ATOM   3379 C C     . LEU   A 1 592  ? 105.793 179.662 162.321 1.00 70.16  ?  592  LEU   C C     1 
ATOM   3380 O O     . LEU   A 1 592  ? 106.208 179.603 163.475 1.00 67.94  ?  592  LEU   C O     1 
ATOM   3381 C CB    . LEU   A 1 592  ? 104.002 178.267 161.272 1.00 73.12  ?  592  LEU   C CB    1 
ATOM   3382 C CG    . LEU   A 1 592  ? 102.515 177.958 160.952 1.00 71.33  ?  592  LEU   C CG    1 
ATOM   3383 C CD1   . LEU   A 1 592  ? 102.464 176.734 160.039 1.00 61.78  ?  592  LEU   C CD1   1 
ATOM   3384 C CD2   . LEU   A 1 592  ? 101.728 177.713 162.243 1.00 67.77  ?  592  LEU   C CD2   1 
ATOM   3385 N N     . GLU   A 1 593  ? 106.602 179.839 161.282 1.00 69.56  ?  593  GLU   C N     1 
ATOM   3386 C CA    . GLU   A 1 593  ? 108.055 179.921 161.420 1.00 66.07  ?  593  GLU   C CA    1 
ATOM   3387 C C     . GLU   A 1 593  ? 108.473 181.023 162.399 1.00 64.86  ?  593  GLU   C C     1 
ATOM   3388 O O     . GLU   A 1 593  ? 109.483 180.910 163.094 1.00 59.89  ?  593  GLU   C O     1 
ATOM   3389 C CB    . GLU   A 1 593  ? 108.702 180.157 160.053 1.00 67.53  ?  593  GLU   C CB    1 
ATOM   3390 C CG    . GLU   A 1 593  ? 110.215 179.981 160.043 1.00 70.83  ?  593  GLU   C CG    1 
ATOM   3391 C CD    . GLU   A 1 593  ? 110.841 180.163 158.683 1.00 71.93  ?  593  GLU   C CD    1 
ATOM   3392 O OE1   . GLU   A 1 593  ? 110.192 180.648 157.796 1.00 70.39  ?  593  GLU   C OE1   1 
ATOM   3393 O OE2   . GLU   A 1 593  ? 111.987 179.829 158.539 1.00 69.30  -1 593  GLU   C OE2   1 
ATOM   3394 N N     . LYS   A 1 594  ? 107.696 182.096 162.460 1.00 68.20  ?  594  LYS   C N     1 
ATOM   3395 C CA    . LYS   A 1 594  ? 108.003 183.211 163.352 1.00 71.23  ?  594  LYS   C CA    1 
ATOM   3396 C C     . LYS   A 1 594  ? 107.824 182.854 164.829 1.00 66.56  ?  594  LYS   C C     1 
ATOM   3397 O O     . LYS   A 1 594  ? 108.188 183.638 165.704 1.00 63.29  ?  594  LYS   C O     1 
ATOM   3398 C CB    . LYS   A 1 594  ? 107.149 184.433 163.022 1.00 67.94  ?  594  LYS   C CB    1 
ATOM   3399 C CG    . LYS   A 1 594  ? 105.656 184.276 163.306 1.00 71.12  ?  594  LYS   C CG    1 
ATOM   3400 C CD    . LYS   A 1 594  ? 104.874 185.520 162.876 1.00 80.18  ?  594  LYS   C CD    1 
ATOM   3401 C CE    . LYS   A 1 594  ? 105.110 186.701 163.823 1.00 83.67  ?  594  LYS   C CE    1 
ATOM   3402 N NZ    . LYS   A 1 594  ? 104.233 187.854 163.495 1.00 79.79  1  594  LYS   C NZ    1 
ATOM   3403 N N     . LYS   A 1 595  ? 107.238 181.692 165.107 1.00 62.86  ?  595  LYS   C N     1 
ATOM   3404 C CA    . LYS   A 1 595  ? 106.970 181.270 166.477 1.00 61.63  ?  595  LYS   C CA    1 
ATOM   3405 C C     . LYS   A 1 595  ? 108.156 180.520 167.073 1.00 57.89  ?  595  LYS   C C     1 
ATOM   3406 O O     . LYS   A 1 595  ? 108.104 180.063 168.220 1.00 54.58  ?  595  LYS   C O     1 
ATOM   3407 C CB    . LYS   A 1 595  ? 105.721 180.392 166.531 1.00 65.86  ?  595  LYS   C CB    1 
ATOM   3408 C CG    . LYS   A 1 595  ? 104.444 181.104 166.120 1.00 69.77  ?  595  LYS   C CG    1 
ATOM   3409 C CD    . LYS   A 1 595  ? 103.243 180.175 166.197 1.00 67.57  ?  595  LYS   C CD    1 
ATOM   3410 C CE    . LYS   A 1 595  ? 101.963 180.873 165.756 1.00 78.24  ?  595  LYS   C CE    1 
ATOM   3411 N NZ    . LYS   A 1 595  ? 101.555 181.952 166.708 1.00 82.33  1  595  LYS   C NZ    1 
ATOM   3412 N N     . LEU   A 1 596  ? 109.220 180.394 166.288 1.00 55.21  ?  596  LEU   C N     1 
ATOM   3413 C CA    . LEU   A 1 596  ? 110.426 179.724 166.739 1.00 49.92  ?  596  LEU   C CA    1 
ATOM   3414 C C     . LEU   A 1 596  ? 111.304 180.722 167.482 1.00 49.93  ?  596  LEU   C C     1 
ATOM   3415 O O     . LEU   A 1 596  ? 111.308 181.911 167.165 1.00 53.90  ?  596  LEU   C O     1 
ATOM   3416 C CB    . LEU   A 1 596  ? 111.175 179.132 165.538 1.00 50.31  ?  596  LEU   C CB    1 
ATOM   3417 C CG    . LEU   A 1 596  ? 110.345 178.186 164.625 1.00 49.00  ?  596  LEU   C CG    1 
ATOM   3418 C CD1   . LEU   A 1 596  ? 111.246 177.624 163.529 1.00 41.63  ?  596  LEU   C CD1   1 
ATOM   3419 C CD2   . LEU   A 1 596  ? 109.716 177.098 165.453 1.00 43.77  ?  596  LEU   C CD2   1 
ATOM   3420 N N     . SER   A 1 597  ? 112.041 180.240 168.473 1.00 45.90  ?  597  SER   C N     1 
ATOM   3421 C CA    . SER   A 1 597  ? 112.889 181.110 169.284 1.00 48.42  ?  597  SER   C CA    1 
ATOM   3422 C C     . SER   A 1 597  ? 114.228 181.409 168.644 1.00 49.35  ?  597  SER   C C     1 
ATOM   3423 O O     . SER   A 1 597  ? 114.945 180.501 168.222 1.00 46.59  ?  597  SER   C O     1 
ATOM   3424 C CB    . SER   A 1 597  ? 113.117 180.493 170.639 1.00 47.66  ?  597  SER   C CB    1 
ATOM   3425 O OG    . SER   A 1 597  ? 114.118 181.174 171.348 1.00 48.75  ?  597  SER   C OG    1 
ATOM   3426 N N     . CYS   A 1 598  ? 114.575 182.692 168.594 1.00 51.45  ?  598  CYS   C N     1 
ATOM   3427 C CA    . CYS   A 1 598  ? 115.859 183.111 168.051 1.00 50.49  ?  598  CYS   C CA    1 
ATOM   3428 C C     . CYS   A 1 598  ? 116.995 182.705 168.976 1.00 47.95  ?  598  CYS   C C     1 
ATOM   3429 O O     . CYS   A 1 598  ? 118.083 182.355 168.520 1.00 48.90  ?  598  CYS   C O     1 
ATOM   3430 C CB    . CYS   A 1 598  ? 115.886 184.620 167.829 1.00 58.08  ?  598  CYS   C CB    1 
ATOM   3431 S SG    . CYS   A 1 598  ? 114.819 185.171 166.479 1.00 66.58  ?  598  CYS   C SG    1 
ATOM   3432 N N     . LYS   A 1 599  ? 116.738 182.741 170.281 1.00 49.63  ?  599  LYS   C N     1 
ATOM   3433 C CA    . LYS   A 1 599  ? 117.754 182.354 171.246 1.00 47.47  ?  599  LYS   C CA    1 
ATOM   3434 C C     . LYS   A 1 599  ? 118.074 180.876 171.111 1.00 47.55  ?  599  LYS   C C     1 
ATOM   3435 O O     . LYS   A 1 599  ? 119.240 180.480 171.153 1.00 45.88  ?  599  LYS   C O     1 
ATOM   3436 C CB    . LYS   A 1 599  ? 117.303 182.667 172.671 1.00 55.32  ?  599  LYS   C CB    1 
ATOM   3437 C CG    . LYS   A 1 599  ? 117.265 184.149 173.006 1.00 65.23  ?  599  LYS   C CG    1 
ATOM   3438 C CD    . LYS   A 1 599  ? 116.807 184.376 174.437 1.00 71.26  ?  599  LYS   C CD    1 
ATOM   3439 C CE    . LYS   A 1 599  ? 116.784 185.857 174.792 1.00 78.22  ?  599  LYS   C CE    1 
ATOM   3440 N NZ    . LYS   A 1 599  ? 116.305 186.078 176.182 1.00 74.82  1  599  LYS   C NZ    1 
ATOM   3441 N N     . ILE   A 1 600  ? 117.040 180.061 170.917 1.00 46.46  ?  600  ILE   C N     1 
ATOM   3442 C CA    . ILE   A 1 600  ? 117.264 178.638 170.723 1.00 45.75  ?  600  ILE   C CA    1 
ATOM   3443 C C     . ILE   A 1 600  ? 117.937 178.405 169.383 1.00 42.71  ?  600  ILE   C C     1 
ATOM   3444 O O     . ILE   A 1 600  ? 118.890 177.635 169.283 1.00 41.06  ?  600  ILE   C O     1 
ATOM   3445 C CB    . ILE   A 1 600  ? 115.965 177.817 170.812 1.00 44.42  ?  600  ILE   C CB    1 
ATOM   3446 C CG1   . ILE   A 1 600  ? 115.424 177.853 172.257 1.00 48.35  ?  600  ILE   C CG1   1 
ATOM   3447 C CG2   . ILE   A 1 600  ? 116.233 176.388 170.367 1.00 43.60  ?  600  ILE   C CG2   1 
ATOM   3448 C CD1   . ILE   A 1 600  ? 114.030 177.247 172.426 1.00 48.31  ?  600  ILE   C CD1   1 
ATOM   3449 N N     . SER   A 1 601  ? 117.457 179.081 168.347 1.00 43.95  ?  601  SER   C N     1 
ATOM   3450 C CA    . SER   A 1 601  ? 118.020 178.908 167.021 1.00 39.44  ?  601  SER   C CA    1 
ATOM   3451 C C     . SER   A 1 601  ? 119.532 179.078 167.045 1.00 39.74  ?  601  SER   C C     1 
ATOM   3452 O O     . SER   A 1 601  ? 120.258 178.257 166.481 1.00 36.48  ?  601  SER   C O     1 
ATOM   3453 C CB    . SER   A 1 601  ? 117.397 179.902 166.063 1.00 39.70  ?  601  SER   C CB    1 
ATOM   3454 O OG    . SER   A 1 601  ? 117.920 179.758 164.778 1.00 40.95  ?  601  SER   C OG    1 
ATOM   3455 N N     . GLN   A 1 602  ? 120.019 180.116 167.723 1.00 41.63  ?  602  GLN   C N     1 
ATOM   3456 C CA    . GLN   A 1 602  ? 121.459 180.323 167.805 1.00 40.33  ?  602  GLN   C CA    1 
ATOM   3457 C C     . GLN   A 1 602  ? 122.153 179.207 168.579 1.00 38.64  ?  602  GLN   C C     1 
ATOM   3458 O O     . GLN   A 1 602  ? 123.230 178.755 168.188 1.00 38.56  ?  602  GLN   C O     1 
ATOM   3459 C CB    . GLN   A 1 602  ? 121.773 181.667 168.455 1.00 41.34  ?  602  GLN   C CB    1 
ATOM   3460 C CG    . GLN   A 1 602  ? 121.451 182.865 167.589 1.00 48.68  ?  602  GLN   C CG    1 
ATOM   3461 C CD    . GLN   A 1 602  ? 122.265 182.867 166.310 1.00 55.92  ?  602  GLN   C CD    1 
ATOM   3462 O OE1   . GLN   A 1 602  ? 123.410 182.395 166.295 1.00 50.72  ?  602  GLN   C OE1   1 
ATOM   3463 N NE2   . GLN   A 1 602  ? 121.689 183.396 165.237 1.00 51.28  ?  602  GLN   C NE2   1 
ATOM   3464 N N     . GLN   A 1 603  ? 121.527 178.729 169.648 1.00 38.17  ?  603  GLN   C N     1 
ATOM   3465 C CA    . GLN   A 1 603  ? 122.124 177.653 170.426 1.00 38.02  ?  603  GLN   C CA    1 
ATOM   3466 C C     . GLN   A 1 603  ? 122.248 176.390 169.587 1.00 34.57  ?  603  GLN   C C     1 
ATOM   3467 O O     . GLN   A 1 603  ? 123.255 175.683 169.660 1.00 36.42  ?  603  GLN   C O     1 
ATOM   3468 C CB    . GLN   A 1 603  ? 121.283 177.367 171.669 1.00 44.89  ?  603  GLN   C CB    1 
ATOM   3469 C CG    . GLN   A 1 603  ? 121.322 178.466 172.712 1.00 51.39  ?  603  GLN   C CG    1 
ATOM   3470 C CD    . GLN   A 1 603  ? 120.282 178.265 173.800 1.00 58.20  ?  603  GLN   C CD    1 
ATOM   3471 O OE1   . GLN   A 1 603  ? 119.351 177.466 173.650 1.00 52.77  ?  603  GLN   C OE1   1 
ATOM   3472 N NE2   . GLN   A 1 603  ? 120.432 178.990 174.902 1.00 58.21  ?  603  GLN   C NE2   1 
ATOM   3473 N N     . ILE   A 1 604  ? 121.226 176.120 168.782 1.00 34.54  ?  604  ILE   C N     1 
ATOM   3474 C CA    . ILE   A 1 604  ? 121.220 174.943 167.929 1.00 34.38  ?  604  ILE   C CA    1 
ATOM   3475 C C     . ILE   A 1 604  ? 122.227 175.111 166.807 1.00 31.93  ?  604  ILE   C C     1 
ATOM   3476 O O     . ILE   A 1 604  ? 122.981 174.189 166.497 1.00 28.47  ?  604  ILE   C O     1 
ATOM   3477 C CB    . ILE   A 1 604  ? 119.820 174.688 167.334 1.00 33.77  ?  604  ILE   C CB    1 
ATOM   3478 C CG1   . ILE   A 1 604  ? 118.778 174.459 168.461 1.00 37.24  ?  604  ILE   C CG1   1 
ATOM   3479 C CG2   . ILE   A 1 604  ? 119.870 173.480 166.397 1.00 29.63  ?  604  ILE   C CG2   1 
ATOM   3480 C CD1   . ILE   A 1 604  ? 119.024 173.269 169.331 1.00 39.08  ?  604  ILE   C CD1   1 
ATOM   3481 N N     . ARG   A 1 605  ? 122.251 176.292 166.205 1.00 30.75  ?  605  ARG   C N     1 
ATOM   3482 C CA    . ARG   A 1 605  ? 123.149 176.561 165.098 1.00 27.49  ?  605  ARG   C CA    1 
ATOM   3483 C C     . ARG   A 1 605  ? 124.584 176.230 165.476 1.00 27.96  ?  605  ARG   C C     1 
ATOM   3484 O O     . ARG   A 1 605  ? 125.298 175.571 164.718 1.00 28.52  ?  605  ARG   C O     1 
ATOM   3485 C CB    . ARG   A 1 605  ? 123.048 178.023 164.686 1.00 31.47  ?  605  ARG   C CB    1 
ATOM   3486 C CG    . ARG   A 1 605  ? 123.815 178.394 163.441 1.00 34.62  ?  605  ARG   C CG    1 
ATOM   3487 C CD    . ARG   A 1 605  ? 123.676 179.838 163.109 1.00 37.10  ?  605  ARG   C CD    1 
ATOM   3488 N NE    . ARG   A 1 605  ? 124.304 180.704 164.104 1.00 45.14  ?  605  ARG   C NE    1 
ATOM   3489 C CZ    . ARG   A 1 605  ? 125.621 180.982 164.181 1.00 54.36  ?  605  ARG   C CZ    1 
ATOM   3490 N NH1   . ARG   A 1 605  ? 126.476 180.463 163.322 1.00 48.99  1  605  ARG   C NH1   1 
ATOM   3491 N NH2   . ARG   A 1 605  ? 126.044 181.793 165.131 1.00 52.05  ?  605  ARG   C NH2   1 
ATOM   3492 N N     . LEU   A 1 606  ? 125.003 176.667 166.656 1.00 30.34  ?  606  LEU   C N     1 
ATOM   3493 C CA    . LEU   A 1 606  ? 126.364 176.416 167.102 1.00 29.18  ?  606  LEU   C CA    1 
ATOM   3494 C C     . LEU   A 1 606  ? 126.622 174.931 167.324 1.00 29.55  ?  606  LEU   C C     1 
ATOM   3495 O O     . LEU   A 1 606  ? 127.694 174.423 166.985 1.00 29.97  ?  606  LEU   C O     1 
ATOM   3496 C CB    . LEU   A 1 606  ? 126.637 177.194 168.390 1.00 31.59  ?  606  LEU   C CB    1 
ATOM   3497 C CG    . LEU   A 1 606  ? 126.670 178.728 168.254 1.00 39.41  ?  606  LEU   C CG    1 
ATOM   3498 C CD1   . LEU   A 1 606  ? 126.725 179.346 169.640 1.00 44.48  ?  606  LEU   C CD1   1 
ATOM   3499 C CD2   . LEU   A 1 606  ? 127.883 179.153 167.426 1.00 43.34  ?  606  LEU   C CD2   1 
ATOM   3500 N N     . GLU   A 1 607  ? 125.638 174.222 167.868 1.00 29.53  ?  607  GLU   C N     1 
ATOM   3501 C CA    . GLU   A 1 607  ? 125.801 172.792 168.092 1.00 29.60  ?  607  GLU   C CA    1 
ATOM   3502 C C     . GLU   A 1 607  ? 125.897 172.045 166.771 1.00 27.40  ?  607  GLU   C C     1 
ATOM   3503 O O     . GLU   A 1 607  ? 126.638 171.067 166.656 1.00 28.29  ?  607  GLU   C O     1 
ATOM   3504 C CB    . GLU   A 1 607  ? 124.646 172.230 168.920 1.00 36.14  ?  607  GLU   C CB    1 
ATOM   3505 C CG    . GLU   A 1 607  ? 124.619 172.701 170.370 1.00 41.89  ?  607  GLU   C CG    1 
ATOM   3506 C CD    . GLU   A 1 607  ? 125.834 172.289 171.156 1.00 47.93  ?  607  GLU   C CD    1 
ATOM   3507 O OE1   . GLU   A 1 607  ? 126.214 171.146 171.083 1.00 44.34  ?  607  GLU   C OE1   1 
ATOM   3508 O OE2   . GLU   A 1 607  ? 126.394 173.131 171.826 1.00 47.46  -1 607  GLU   C OE2   1 
ATOM   3509 N N     . LEU   A 1 608  ? 125.162 172.513 165.767 1.00 24.73  ?  608  LEU   C N     1 
ATOM   3510 C CA    . LEU   A 1 608  ? 125.194 171.870 164.464 1.00 23.36  ?  608  LEU   C CA    1 
ATOM   3511 C C     . LEU   A 1 608  ? 126.572 172.010 163.822 1.00 24.59  ?  608  LEU   C C     1 
ATOM   3512 O O     . LEU   A 1 608  ? 127.057 171.073 163.186 1.00 24.01  ?  608  LEU   C O     1 
ATOM   3513 C CB    . LEU   A 1 608  ? 124.120 172.459 163.545 1.00 21.07  ?  608  LEU   C CB    1 
ATOM   3514 C CG    . LEU   A 1 608  ? 122.647 172.180 163.939 1.00 19.51  ?  608  LEU   C CG    1 
ATOM   3515 C CD1   . LEU   A 1 608  ? 121.733 172.957 162.999 1.00 18.03  ?  608  LEU   C CD1   1 
ATOM   3516 C CD2   . LEU   A 1 608  ? 122.350 170.683 163.880 1.00 16.17  ?  608  LEU   C CD2   1 
ATOM   3517 N N     . LEU   A 1 609  ? 127.220 173.162 164.006 1.00 25.74  ?  609  LEU   C N     1 
ATOM   3518 C CA    . LEU   A 1 609  ? 128.565 173.336 163.465 1.00 24.51  ?  609  LEU   C CA    1 
ATOM   3519 C C     . LEU   A 1 609  ? 129.540 172.368 164.107 1.00 23.26  ?  609  LEU   C C     1 
ATOM   3520 O O     . LEU   A 1 609  ? 130.349 171.748 163.416 1.00 25.26  ?  609  LEU   C O     1 
ATOM   3521 C CB    . LEU   A 1 609  ? 129.071 174.766 163.694 1.00 25.78  ?  609  LEU   C CB    1 
ATOM   3522 C CG    . LEU   A 1 609  ? 128.437 175.852 162.837 1.00 29.13  ?  609  LEU   C CG    1 
ATOM   3523 C CD1   . LEU   A 1 609  ? 128.816 177.217 163.380 1.00 32.75  ?  609  LEU   C CD1   1 
ATOM   3524 C CD2   . LEU   A 1 609  ? 128.920 175.710 161.381 1.00 27.46  ?  609  LEU   C CD2   1 
ATOM   3525 N N     . LYS   A 1 610  ? 129.443 172.212 165.423 1.00 24.88  ?  610  LYS   C N     1 
ATOM   3526 C CA    . LYS   A 1 610  ? 130.316 171.281 166.122 1.00 26.10  ?  610  LYS   C CA    1 
ATOM   3527 C C     . LYS   A 1 610  ? 130.067 169.860 165.650 1.00 26.20  ?  610  LYS   C C     1 
ATOM   3528 O O     . LYS   A 1 610  ? 131.005 169.079 165.476 1.00 26.29  ?  610  LYS   C O     1 
ATOM   3529 C CB    . LYS   A 1 610  ? 130.113 171.380 167.631 1.00 29.16  ?  610  LYS   C CB    1 
ATOM   3530 C CG    . LYS   A 1 610  ? 130.662 172.659 168.250 1.00 34.07  ?  610  LYS   C CG    1 
ATOM   3531 C CD    . LYS   A 1 610  ? 130.630 172.608 169.773 1.00 41.12  ?  610  LYS   C CD    1 
ATOM   3532 C CE    . LYS   A 1 610  ? 129.217 172.784 170.303 1.00 45.58  ?  610  LYS   C CE    1 
ATOM   3533 N NZ    . LYS   A 1 610  ? 129.184 172.892 171.793 1.00 49.53  1  610  LYS   C NZ    1 
ATOM   3534 N N     . TRP   A 1 611  ? 128.803 169.531 165.421 1.00 25.51  ?  611  TRP   C N     1 
ATOM   3535 C CA    . TRP   A 1 611  ? 128.436 168.206 164.955 1.00 24.35  ?  611  TRP   C CA    1 
ATOM   3536 C C     . TRP   A 1 611  ? 129.091 167.913 163.614 1.00 23.02  ?  611  TRP   C C     1 
ATOM   3537 O O     . TRP   A 1 611  ? 129.686 166.850 163.428 1.00 24.76  ?  611  TRP   C O     1 
ATOM   3538 C CB    . TRP   A 1 611  ? 126.918 168.093 164.862 1.00 23.08  ?  611  TRP   C CB    1 
ATOM   3539 C CG    . TRP   A 1 611  ? 126.420 166.737 164.513 1.00 20.84  ?  611  TRP   C CG    1 
ATOM   3540 C CD1   . TRP   A 1 611  ? 126.397 165.652 165.329 1.00 21.99  ?  611  TRP   C CD1   1 
ATOM   3541 C CD2   . TRP   A 1 611  ? 125.831 166.313 163.270 1.00 19.04  ?  611  TRP   C CD2   1 
ATOM   3542 N NE1   . TRP   A 1 611  ? 125.845 164.588 164.681 1.00 20.18  ?  611  TRP   C NE1   1 
ATOM   3543 C CE2   . TRP   A 1 611  ? 125.490 164.972 163.420 1.00 17.73  ?  611  TRP   C CE2   1 
ATOM   3544 C CE3   . TRP   A 1 611  ? 125.556 166.956 162.067 1.00 18.04  ?  611  TRP   C CE3   1 
ATOM   3545 C CZ2   . TRP   A 1 611  ? 124.899 164.253 162.409 1.00 14.38  ?  611  TRP   C CZ2   1 
ATOM   3546 C CZ3   . TRP   A 1 611  ? 124.958 166.233 161.051 1.00 17.66  ?  611  TRP   C CZ3   1 
ATOM   3547 C CH2   . TRP   A 1 611  ? 124.638 164.915 161.220 1.00 16.06  ?  611  TRP   C CH2   1 
ATOM   3548 N N     . ILE   A 1 612  ? 129.024 168.869 162.692 1.00 23.67  ?  612  ILE   C N     1 
ATOM   3549 C CA    . ILE   A 1 612  ? 129.654 168.687 161.396 1.00 20.99  ?  612  ILE   C CA    1 
ATOM   3550 C C     . ILE   A 1 612  ? 131.156 168.519 161.528 1.00 23.53  ?  612  ILE   C C     1 
ATOM   3551 O O     . ILE   A 1 612  ? 131.738 167.643 160.891 1.00 24.57  ?  612  ILE   C O     1 
ATOM   3552 C CB    . ILE   A 1 612  ? 129.366 169.862 160.446 1.00 20.40  ?  612  ILE   C CB    1 
ATOM   3553 C CG1   . ILE   A 1 612  ? 127.894 169.855 160.058 1.00 19.41  ?  612  ILE   C CG1   1 
ATOM   3554 C CG2   . ILE   A 1 612  ? 130.270 169.763 159.200 1.00 23.30  ?  612  ILE   C CG2   1 
ATOM   3555 C CD1   . ILE   A 1 612  ? 127.443 171.108 159.360 1.00 22.62  ?  612  ILE   C CD1   1 
ATOM   3556 N N     . GLU   A 1 613  ? 131.799 169.353 162.340 1.00 25.78  ?  613  GLU   C N     1 
ATOM   3557 C CA    . GLU   A 1 613  ? 133.245 169.249 162.477 1.00 24.78  ?  613  GLU   C CA    1 
ATOM   3558 C C     . GLU   A 1 613  ? 133.656 167.852 162.905 1.00 23.49  ?  613  GLU   C C     1 
ATOM   3559 O O     . GLU   A 1 613  ? 134.623 167.295 162.387 1.00 29.34  ?  613  GLU   C O     1 
ATOM   3560 C CB    . GLU   A 1 613  ? 133.787 170.259 163.486 1.00 26.49  ?  613  GLU   C CB    1 
ATOM   3561 C CG    . GLU   A 1 613  ? 135.306 170.187 163.655 1.00 32.79  ?  613  GLU   C CG    1 
ATOM   3562 C CD    . GLU   A 1 613  ? 135.870 171.272 164.524 1.00 37.10  ?  613  GLU   C CD    1 
ATOM   3563 O OE1   . GLU   A 1 613  ? 135.113 172.026 165.080 1.00 36.73  ?  613  GLU   C OE1   1 
ATOM   3564 O OE2   . GLU   A 1 613  ? 137.074 171.350 164.625 1.00 41.81  -1 613  GLU   C OE2   1 
ATOM   3565 N N     . VAL   A 1 614  ? 132.920 167.281 163.847 1.00 22.47  ?  614  VAL   C N     1 
ATOM   3566 C CA    . VAL   A 1 614  ? 133.232 165.951 164.341 1.00 23.06  ?  614  VAL   C CA    1 
ATOM   3567 C C     . VAL   A 1 614  ? 132.967 164.870 163.302 1.00 25.94  ?  614  VAL   C C     1 
ATOM   3568 O O     . VAL   A 1 614  ? 133.791 163.980 163.105 1.00 28.70  ?  614  VAL   C O     1 
ATOM   3569 C CB    . VAL   A 1 614  ? 132.418 165.653 165.610 1.00 25.05  ?  614  VAL   C CB    1 
ATOM   3570 C CG1   . VAL   A 1 614  ? 132.613 164.201 166.037 1.00 26.99  ?  614  VAL   C CG1   1 
ATOM   3571 C CG2   . VAL   A 1 614  ? 132.862 166.593 166.718 1.00 28.34  ?  614  VAL   C CG2   1 
ATOM   3572 N N     . LYS   A 1 615  ? 131.814 164.936 162.644 1.00 25.77  ?  615  LYS   C N     1 
ATOM   3573 C CA    . LYS   A 1 615  ? 131.440 163.900 161.687 1.00 25.66  ?  615  LYS   C CA    1 
ATOM   3574 C C     . LYS   A 1 615  ? 132.238 163.997 160.394 1.00 25.74  ?  615  LYS   C C     1 
ATOM   3575 O O     . LYS   A 1 615  ? 132.438 162.996 159.707 1.00 29.17  ?  615  LYS   C O     1 
ATOM   3576 C CB    . LYS   A 1 615  ? 129.940 163.961 161.399 1.00 21.01  ?  615  LYS   C CB    1 
ATOM   3577 C CG    . LYS   A 1 615  ? 129.046 163.690 162.617 1.00 21.22  ?  615  LYS   C CG    1 
ATOM   3578 C CD    . LYS   A 1 615  ? 129.310 162.318 163.229 1.00 24.11  ?  615  LYS   C CD    1 
ATOM   3579 C CE    . LYS   A 1 615  ? 128.338 162.020 164.348 1.00 23.76  ?  615  LYS   C CE    1 
ATOM   3580 N NZ    . LYS   A 1 615  ? 128.652 160.732 165.026 1.00 20.16  1  615  LYS   C NZ    1 
ATOM   3581 N N     . ALA   A 1 616  ? 132.725 165.191 160.081 1.00 23.27  ?  616  ALA   C N     1 
ATOM   3582 C CA    . ALA   A 1 616  ? 133.539 165.418 158.895 1.00 24.44  ?  616  ALA   C CA    1 
ATOM   3583 C C     . ALA   A 1 616  ? 134.869 164.667 158.978 1.00 30.90  ?  616  ALA   C C     1 
ATOM   3584 O O     . ALA   A 1 616  ? 135.552 164.494 157.969 1.00 29.08  ?  616  ALA   C O     1 
ATOM   3585 C CB    . ALA   A 1 616  ? 133.792 166.906 158.715 1.00 22.39  ?  616  ALA   C CB    1 
ATOM   3586 N N     . LYS   A 1 617  ? 135.255 164.244 160.181 1.00 35.23  ?  617  LYS   C N     1 
ATOM   3587 C CA    . LYS   A 1 617  ? 136.515 163.539 160.376 1.00 37.82  ?  617  LYS   C CA    1 
ATOM   3588 C C     . LYS   A 1 617  ? 136.262 162.164 160.979 1.00 40.57  ?  617  LYS   C C     1 
ATOM   3589 O O     . LYS   A 1 617  ? 136.397 161.976 162.189 1.00 37.82  ?  617  LYS   C O     1 
ATOM   3590 C CB    . LYS   A 1 617  ? 137.428 164.347 161.295 1.00 39.10  ?  617  LYS   C CB    1 
ATOM   3591 C CG    . LYS   A 1 617  ? 137.776 165.737 160.777 1.00 41.26  ?  617  LYS   C CG    1 
ATOM   3592 C CD    . LYS   A 1 617  ? 138.714 166.477 161.732 1.00 53.69  ?  617  LYS   C CD    1 
ATOM   3593 C CE    . LYS   A 1 617  ? 137.975 166.989 162.970 1.00 46.97  ?  617  LYS   C CE    1 
ATOM   3594 N NZ    . LYS   A 1 617  ? 138.834 167.871 163.804 1.00 31.91  1  617  LYS   C NZ    1 
ATOM   3595 N N     . ALA   A 1 618  ? 135.868 161.207 160.144 1.00 45.90  ?  618  ALA   C N     1 
ATOM   3596 C CA    . ALA   A 1 618  ? 135.473 159.900 160.651 1.00 54.63  ?  618  ALA   C CA    1 
ATOM   3597 C C     . ALA   A 1 618  ? 135.598 158.813 159.590 1.00 56.22  ?  618  ALA   C C     1 
ATOM   3598 O O     . ALA   A 1 618  ? 135.571 159.092 158.391 1.00 50.86  ?  618  ALA   C O     1 
ATOM   3599 C CB    . ALA   A 1 618  ? 134.041 159.960 161.159 1.00 48.80  ?  618  ALA   C CB    1 
ATOM   3600 N N     . LYS   A 1 619  ? 135.699 157.567 160.047 1.00 58.96  ?  619  LYS   C N     1 
ATOM   3601 C CA    . LYS   A 1 619  ? 135.678 156.408 159.163 1.00 61.32  ?  619  LYS   C CA    1 
ATOM   3602 C C     . LYS   A 1 619  ? 134.239 156.094 158.776 1.00 61.47  ?  619  LYS   C C     1 
ATOM   3603 O O     . LYS   A 1 619  ? 133.328 156.248 159.588 1.00 59.75  ?  619  LYS   C O     1 
ATOM   3604 C CB    . LYS   A 1 619  ? 136.317 155.201 159.846 1.00 67.41  ?  619  LYS   C CB    1 
ATOM   3605 C CG    . LYS   A 1 619  ? 137.799 155.345 160.131 1.00 75.43  ?  619  LYS   C CG    1 
ATOM   3606 C CD    . LYS   A 1 619  ? 138.344 154.096 160.810 1.00 76.04  ?  619  LYS   C CD    1 
ATOM   3607 C CE    . LYS   A 1 619  ? 139.827 154.231 161.116 1.00 89.80  ?  619  LYS   C CE    1 
ATOM   3608 N NZ    . LYS   A 1 619  ? 140.363 153.025 161.810 1.00 81.56  1  619  LYS   C NZ    1 
ATOM   3609 N N     . LYS   A 1 620  ? 134.033 155.638 157.545 1.00 60.17  ?  620  LYS   C N     1 
ATOM   3610 C CA    . LYS   A 1 620  ? 132.684 155.342 157.070 1.00 62.40  ?  620  LYS   C CA    1 
ATOM   3611 C C     . LYS   A 1 620  ? 131.963 154.343 157.971 1.00 57.76  ?  620  LYS   C C     1 
ATOM   3612 O O     . LYS   A 1 620  ? 130.964 154.674 158.603 1.00 53.91  ?  620  LYS   C O     1 
ATOM   3613 C CB    . LYS   A 1 620  ? 132.743 154.790 155.646 1.00 62.35  ?  620  LYS   C CB    1 
ATOM   3614 C CG    . LYS   A 1 620  ? 133.184 155.794 154.594 1.00 63.29  ?  620  LYS   C CG    1 
ATOM   3615 C CD    . LYS   A 1 620  ? 133.269 155.137 153.221 1.00 68.23  ?  620  LYS   C CD    1 
ATOM   3616 C CE    . LYS   A 1 620  ? 133.875 156.076 152.177 1.00 68.95  ?  620  LYS   C CE    1 
ATOM   3617 N NZ    . LYS   A 1 620  ? 134.023 155.405 150.859 1.00 54.74  1  620  LYS   C NZ    1 
ATOM   3618 N N     . LEU   A 1 621  ? 132.480 153.117 158.019 1.00 57.41  ?  621  LEU   C N     1 
ATOM   3619 C CA    . LEU   A 1 621  ? 131.956 152.056 158.884 1.00 57.56  ?  621  LEU   C CA    1 
ATOM   3620 C C     . LEU   A 1 621  ? 130.452 151.838 158.735 1.00 56.98  ?  621  LEU   C C     1 
ATOM   3621 O O     . LEU   A 1 621  ? 129.799 151.363 159.665 1.00 55.57  ?  621  LEU   C O     1 
ATOM   3622 C CB    . LEU   A 1 621  ? 132.269 152.389 160.343 1.00 58.82  ?  621  LEU   C CB    1 
ATOM   3623 C CG    . LEU   A 1 621  ? 133.739 152.689 160.658 1.00 63.76  ?  621  LEU   C CG    1 
ATOM   3624 C CD1   . LEU   A 1 621  ? 133.860 153.095 162.114 1.00 62.67  ?  621  LEU   C CD1   1 
ATOM   3625 C CD2   . LEU   A 1 621  ? 134.601 151.464 160.362 1.00 67.26  ?  621  LEU   C CD2   1 
ATOM   3626 N N     . GLN   A 1 622  ? 129.905 152.183 157.572 1.00 51.30  ?  622  GLN   C N     1 
ATOM   3627 C CA    . GLN   A 1 622  ? 128.473 152.057 157.293 1.00 51.10  ?  622  GLN   C CA    1 
ATOM   3628 C C     . GLN   A 1 622  ? 127.618 152.898 158.247 1.00 45.58  ?  622  GLN   C C     1 
ATOM   3629 O O     . GLN   A 1 622  ? 126.405 152.695 158.352 1.00 42.45  ?  622  GLN   C O     1 
ATOM   3630 C CB    . GLN   A 1 622  ? 128.031 150.589 157.350 1.00 55.95  ?  622  GLN   C CB    1 
ATOM   3631 C CG    . GLN   A 1 622  ? 128.740 149.683 156.355 1.00 59.06  ?  622  GLN   C CG    1 
ATOM   3632 C CD    . GLN   A 1 622  ? 128.206 148.256 156.381 1.00 65.02  ?  622  GLN   C CD    1 
ATOM   3633 O OE1   . GLN   A 1 622  ? 127.019 148.022 156.630 1.00 56.83  ?  622  GLN   C OE1   1 
ATOM   3634 N NE2   . GLN   A 1 622  ? 129.086 147.292 156.123 1.00 62.34  ?  622  GLN   C NE2   1 
ATOM   3635 N N     . ILE   A 1 623  ? 128.291 153.661 159.113 1.00 44.31  ?  623  ILE   C N     1 
ATOM   3636 C CA    . ILE   A 1 623  ? 127.467 154.549 159.967 1.00 41.71  ?  623  ILE   C CA    1 
ATOM   3637 C C     . ILE   A 1 623  ? 127.186 155.724 159.063 1.00 35.62  ?  623  ILE   C C     1 
ATOM   3638 O O     . ILE   A 1 623  ? 127.726 155.768 157.949 1.00 38.16  ?  623  ILE   C O     1 
ATOM   3639 C CB    . ILE   A 1 623  ? 128.060 154.906 161.340 1.00 48.30  ?  623  ILE   C CB    1 
ATOM   3640 C CG1   . ILE   A 1 623  ? 129.293 154.073 161.696 1.00 51.63  ?  623  ILE   C CG1   1 
ATOM   3641 C CG2   . ILE   A 1 623  ? 126.985 154.808 162.410 1.00 48.60  ?  623  ILE   C CG2   1 
ATOM   3642 C CD1   . ILE   A 1 623  ? 130.382 154.860 162.394 1.00 57.06  ?  623  ILE   C CD1   1 
ATOM   3643 N N     . GLN   A 1 624  ? 126.449 156.691 159.573 1.00 32.85  ?  624  GLN   C N     1 
ATOM   3644 C CA    . GLN   A 1 624  ? 126.037 157.635 158.550 1.00 33.49  ?  624  GLN   C CA    1 
ATOM   3645 C C     . GLN   A 1 624  ? 125.819 159.054 158.921 1.00 28.50  ?  624  GLN   C C     1 
ATOM   3646 O O     . GLN   A 1 624  ? 125.149 159.175 159.903 1.00 25.84  ?  624  GLN   C O     1 
ATOM   3647 C CB    . GLN   A 1 624  ? 124.763 157.065 157.904 1.00 34.73  ?  624  GLN   C CB    1 
ATOM   3648 C CG    . GLN   A 1 624  ? 123.921 158.075 157.143 1.00 41.79  ?  624  GLN   C CG    1 
ATOM   3649 C CD    . GLN   A 1 624  ? 124.199 158.042 155.664 1.00 37.49  ?  624  GLN   C CD    1 
ATOM   3650 O OE1   . GLN   A 1 624  ? 124.712 157.070 155.121 1.00 30.82  ?  624  GLN   C OE1   1 
ATOM   3651 N NE2   . GLN   A 1 624  ? 123.858 159.123 154.996 1.00 34.73  ?  624  GLN   C NE2   1 
ATOM   3652 N N     . PRO   A 1 625  ? 126.703 159.978 158.533 1.00 25.75  ?  625  PRO   C N     1 
ATOM   3653 C CA    . PRO   A 1 625  ? 126.458 161.373 158.325 1.00 19.04  ?  625  PRO   C CA    1 
ATOM   3654 C C     . PRO   A 1 625  ? 127.410 161.345 157.099 1.00 17.49  ?  625  PRO   C C     1 
ATOM   3655 O O     . PRO   A 1 625  ? 128.301 162.131 157.051 1.00 20.90  ?  625  PRO   C O     1 
ATOM   3656 C CB    . PRO   A 1 625  ? 126.917 161.972 159.638 1.00 14.06  ?  625  PRO   C CB    1 
ATOM   3657 C CG    . PRO   A 1 625  ? 127.970 160.987 160.113 1.00 27.09  ?  625  PRO   C CG    1 
ATOM   3658 C CD    . PRO   A 1 625  ? 128.072 159.920 159.035 1.00 25.40  ?  625  PRO   C CD    1 
ATOM   3659 N N     . SER   A 1 626  ? 127.207 160.552 156.065 1.00 19.31  ?  626  SER   C N     1 
ATOM   3660 C CA    . SER   A 1 626  ? 128.175 160.306 154.961 1.00 16.39  ?  626  SER   C CA    1 
ATOM   3661 C C     . SER   A 1 626  ? 128.669 161.395 154.035 1.00 14.21  ?  626  SER   C C     1 
ATOM   3662 O O     . SER   A 1 626  ? 128.915 161.003 152.904 1.00 20.29  ?  626  SER   C O     1 
ATOM   3663 C CB    . SER   A 1 626  ? 127.547 159.365 154.062 1.00 26.51  ?  626  SER   C CB    1 
ATOM   3664 O OG    . SER   A 1 626  ? 126.465 159.987 153.400 1.00 23.65  ?  626  SER   C OG    1 
ATOM   3665 N N     . GLN   A 1 627  ? 128.968 162.611 154.440 1.00 14.88  ?  627  GLN   C N     1 
ATOM   3666 C CA    . GLN   A 1 627  ? 129.572 163.621 153.526 1.00 12.63  ?  627  GLN   C CA    1 
ATOM   3667 C C     . GLN   A 1 627  ? 128.534 164.001 152.487 1.00 12.17  ?  627  GLN   C C     1 
ATOM   3668 O O     . GLN   A 1 627  ? 128.193 165.147 152.504 1.00 12.27  ?  627  GLN   C O     1 
ATOM   3669 C CB    . GLN   A 1 627  ? 130.933 163.161 153.025 1.00 16.05  ?  627  GLN   C CB    1 
ATOM   3670 C CG    . GLN   A 1 627  ? 131.962 164.268 152.947 1.00 16.33  ?  627  GLN   C CG    1 
ATOM   3671 C CD    . GLN   A 1 627  ? 133.348 163.693 152.853 1.00 16.78  ?  627  GLN   C CD    1 
ATOM   3672 O OE1   . GLN   A 1 627  ? 133.629 162.858 152.009 1.00 17.74  ?  627  GLN   C OE1   1 
ATOM   3673 N NE2   . GLN   A 1 627  ? 134.225 164.125 153.738 1.00 19.05  ?  627  GLN   C NE2   1 
ATOM   3674 N N     . LEU   A 1 628  ? 128.015 163.104 151.661 1.00 10.43  ?  628  LEU   C N     1 
ATOM   3675 C CA    . LEU   A 1 628  ? 126.891 163.499 150.797 1.00 8.67   ?  628  LEU   C CA    1 
ATOM   3676 C C     . LEU   A 1 628  ? 125.754 163.885 151.719 1.00 10.07  ?  628  LEU   C C     1 
ATOM   3677 O O     . LEU   A 1 628  ? 125.105 164.864 151.455 1.00 11.13  ?  628  LEU   C O     1 
ATOM   3678 C CB    . LEU   A 1 628  ? 126.480 162.372 149.857 1.00 8.13   ?  628  LEU   C CB    1 
ATOM   3679 C CG    . LEU   A 1 628  ? 125.497 162.775 148.767 1.00 6.96   ?  628  LEU   C CG    1 
ATOM   3680 C CD1   . LEU   A 1 628  ? 125.962 164.023 148.048 1.00 9.04   ?  628  LEU   C CD1   1 
ATOM   3681 C CD2   . LEU   A 1 628  ? 125.278 161.642 147.795 1.00 6.07   ?  628  LEU   C CD2   1 
ATOM   3682 N N     . GLU   A 1 629  ? 125.548 163.143 152.786 1.00 11.87  ?  629  GLU   C N     1 
ATOM   3683 C CA    . GLU   A 1 629  ? 124.518 163.496 153.775 1.00 10.11  ?  629  GLU   C CA    1 
ATOM   3684 C C     . GLU   A 1 629  ? 124.824 164.794 154.506 1.00 9.63   ?  629  GLU   C C     1 
ATOM   3685 O O     . GLU   A 1 629  ? 123.915 165.561 154.624 1.00 13.10  ?  629  GLU   C O     1 
ATOM   3686 C CB    . GLU   A 1 629  ? 124.330 162.363 154.750 1.00 14.81  ?  629  GLU   C CB    1 
ATOM   3687 C CG    . GLU   A 1 629  ? 123.165 162.552 155.699 1.00 21.97  ?  629  GLU   C CG    1 
ATOM   3688 C CD    . GLU   A 1 629  ? 121.867 163.066 155.102 1.00 25.54  ?  629  GLU   C CD    1 
ATOM   3689 O OE1   . GLU   A 1 629  ? 121.466 162.564 154.049 1.00 20.13  ?  629  GLU   C OE1   1 
ATOM   3690 O OE2   . GLU   A 1 629  ? 121.262 163.969 155.695 1.00 20.68  -1 629  GLU   C OE2   1 
ATOM   3691 N N     . LEU   A 1 630  ? 126.043 165.074 154.912 1.00 9.75   ?  630  LEU   C N     1 
ATOM   3692 C CA    . LEU   A 1 630  ? 126.299 166.378 155.560 1.00 9.00   ?  630  LEU   C CA    1 
ATOM   3693 C C     . LEU   A 1 630  ? 126.070 167.498 154.566 1.00 8.88   ?  630  LEU   C C     1 
ATOM   3694 O O     . LEU   A 1 630  ? 125.847 168.586 154.984 1.00 11.17  ?  630  LEU   C O     1 
ATOM   3695 C CB    . LEU   A 1 630  ? 127.715 166.446 156.116 1.00 11.75  ?  630  LEU   C CB    1 
ATOM   3696 C CG    . LEU   A 1 630  ? 128.050 165.538 157.289 1.00 13.42  ?  630  LEU   C CG    1 
ATOM   3697 C CD1   . LEU   A 1 630  ? 129.531 165.212 157.281 1.00 17.73  ?  630  LEU   C CD1   1 
ATOM   3698 C CD2   . LEU   A 1 630  ? 127.680 166.215 158.591 1.00 15.56  ?  630  LEU   C CD2   1 
ATOM   3699 N N     . PHE   A 1 631  ? 126.099 167.207 153.290 1.00 10.59  ?  631  PHE   C N     1 
ATOM   3700 C CA    . PHE   A 1 631  ? 125.927 168.218 152.227 1.00 10.58  ?  631  PHE   C CA    1 
ATOM   3701 C C     . PHE   A 1 631  ? 124.463 168.461 151.972 1.00 9.68   ?  631  PHE   C C     1 
ATOM   3702 O O     . PHE   A 1 631  ? 124.137 169.562 151.594 1.00 11.52  ?  631  PHE   C O     1 
ATOM   3703 C CB    . PHE   A 1 631  ? 126.524 167.748 150.907 1.00 11.28  ?  631  PHE   C CB    1 
ATOM   3704 C CG    . PHE   A 1 631  ? 128.023 167.661 150.802 1.00 12.20  ?  631  PHE   C CG    1 
ATOM   3705 C CD1   . PHE   A 1 631  ? 128.853 168.240 151.746 1.00 12.98  ?  631  PHE   C CD1   1 
ATOM   3706 C CD2   . PHE   A 1 631  ? 128.601 166.995 149.737 1.00 11.76  ?  631  PHE   C CD2   1 
ATOM   3707 C CE1   . PHE   A 1 631  ? 130.228 168.146 151.631 1.00 13.77  ?  631  PHE   C CE1   1 
ATOM   3708 C CE2   . PHE   A 1 631  ? 129.976 166.903 149.624 1.00 12.01  ?  631  PHE   C CE2   1 
ATOM   3709 C CZ    . PHE   A 1 631  ? 130.784 167.483 150.569 1.00 12.73  ?  631  PHE   C CZ    1 
ATOM   3710 N N     . TYR   A 1 632  ? 123.621 167.459 152.156 1.00 9.90   ?  632  TYR   C N     1 
ATOM   3711 C CA    . TYR   A 1 632  ? 122.172 167.665 152.055 1.00 8.14   ?  632  TYR   C CA    1 
ATOM   3712 C C     . TYR   A 1 632  ? 121.764 168.478 153.257 1.00 9.24   ?  632  TYR   C C     1 
ATOM   3713 O O     . TYR   A 1 632  ? 120.835 169.216 153.115 1.00 11.25  ?  632  TYR   C O     1 
ATOM   3714 C CB    . TYR   A 1 632  ? 121.479 166.322 152.023 1.00 7.47   ?  632  TYR   C CB    1 
ATOM   3715 C CG    . TYR   A 1 632  ? 121.237 165.684 150.694 1.00 7.14   ?  632  TYR   C CG    1 
ATOM   3716 C CD1   . TYR   A 1 632  ? 122.108 164.746 150.183 1.00 8.66   ?  632  TYR   C CD1   1 
ATOM   3717 C CD2   . TYR   A 1 632  ? 120.093 165.975 149.990 1.00 8.60   ?  632  TYR   C CD2   1 
ATOM   3718 C CE1   . TYR   A 1 632  ? 121.872 164.146 148.964 1.00 7.67   ?  632  TYR   C CE1   1 
ATOM   3719 C CE2   . TYR   A 1 632  ? 119.839 165.382 148.774 1.00 8.69   ?  632  TYR   C CE2   1 
ATOM   3720 C CZ    . TYR   A 1 632  ? 120.732 164.470 148.263 1.00 7.33   ?  632  TYR   C CZ    1 
ATOM   3721 O OH    . TYR   A 1 632  ? 120.467 163.887 147.073 1.00 9.69   ?  632  TYR   C OH    1 
ATOM   3722 N N     . CYS   A 1 633  ? 122.492 168.348 154.381 1.00 11.10  ?  633  CYS   C N     1 
ATOM   3723 C CA    . CYS   A 1 633  ? 122.180 169.150 155.550 1.00 8.79   ?  633  CYS   C CA    1 
ATOM   3724 C C     . CYS   A 1 633  ? 122.554 170.606 155.327 1.00 10.02  ?  633  CYS   C C     1 
ATOM   3725 O O     . CYS   A 1 633  ? 121.782 171.507 155.638 1.00 12.88  ?  633  CYS   C O     1 
ATOM   3726 C CB    . CYS   A 1 633  ? 122.928 168.627 156.766 1.00 9.41   ?  633  CYS   C CB    1 
ATOM   3727 S SG    . CYS   A 1 633  ? 122.352 167.033 157.368 1.00 10.54  ?  633  CYS   C SG    1 
ATOM   3728 N N     . LEU   A 1 634  ? 123.733 170.832 154.761 1.00 10.25  ?  634  LEU   C N     1 
ATOM   3729 C CA    . LEU   A 1 634  ? 124.178 172.191 154.487 1.00 10.81  ?  634  LEU   C CA    1 
ATOM   3730 C C     . LEU   A 1 634  ? 123.367 172.856 153.394 1.00 11.68  ?  634  LEU   C C     1 
ATOM   3731 O O     . LEU   A 1 634  ? 123.053 174.037 153.490 1.00 14.47  ?  634  LEU   C O     1 
ATOM   3732 C CB    . LEU   A 1 634  ? 125.656 172.193 154.094 1.00 12.14  ?  634  LEU   C CB    1 
ATOM   3733 C CG    . LEU   A 1 634  ? 126.641 171.881 155.217 1.00 12.54  ?  634  LEU   C CG    1 
ATOM   3734 C CD1   . LEU   A 1 634  ? 128.030 171.697 154.632 1.00 12.08  ?  634  LEU   C CD1   1 
ATOM   3735 C CD2   . LEU   A 1 634  ? 126.632 173.020 156.216 1.00 15.00  ?  634  LEU   C CD2   1 
ATOM   3736 N N     . TYR   A 1 635  ? 122.995 172.112 152.366 1.00 11.65  ?  635  TYR   C N     1 
ATOM   3737 C CA    . TYR   A 1 635  ? 122.199 172.675 151.286 1.00 11.56  ?  635  TYR   C CA    1 
ATOM   3738 C C     . TYR   A 1 635  ? 120.915 173.292 151.818 1.00 14.39  ?  635  TYR   C C     1 
ATOM   3739 O O     . TYR   A 1 635  ? 120.471 174.344 151.357 1.00 18.19  ?  635  TYR   C O     1 
ATOM   3740 C CB    . TYR   A 1 635  ? 121.871 171.630 150.230 1.00 11.69  ?  635  TYR   C CB    1 
ATOM   3741 C CG    . TYR   A 1 635  ? 121.120 172.213 149.073 1.00 12.40  ?  635  TYR   C CG    1 
ATOM   3742 C CD1   . TYR   A 1 635  ? 121.816 172.794 148.039 1.00 13.51  ?  635  TYR   C CD1   1 
ATOM   3743 C CD2   . TYR   A 1 635  ? 119.743 172.190 149.051 1.00 17.55  ?  635  TYR   C CD2   1 
ATOM   3744 C CE1   . TYR   A 1 635  ? 121.147 173.356 146.985 1.00 14.92  ?  635  TYR   C CE1   1 
ATOM   3745 C CE2   . TYR   A 1 635  ? 119.068 172.755 147.994 1.00 18.87  ?  635  TYR   C CE2   1 
ATOM   3746 C CZ    . TYR   A 1 635  ? 119.766 173.336 146.967 1.00 17.16  ?  635  TYR   C CZ    1 
ATOM   3747 O OH    . TYR   A 1 635  ? 119.089 173.906 145.924 1.00 23.43  ?  635  TYR   C OH    1 
ATOM   3748 N N     . GLU   A 1 636  ? 120.308 172.626 152.794 1.00 15.13  ?  636  GLU   C N     1 
ATOM   3749 C CA    . GLU   A 1 636  ? 119.033 173.071 153.342 1.00 15.45  ?  636  GLU   C CA    1 
ATOM   3750 C C     . GLU   A 1 636  ? 119.090 174.471 153.928 1.00 16.68  ?  636  GLU   C C     1 
ATOM   3751 O O     . GLU   A 1 636  ? 118.055 175.124 154.070 1.00 20.12  ?  636  GLU   C O     1 
ATOM   3752 C CB    . GLU   A 1 636  ? 118.532 172.086 154.385 1.00 13.55  ?  636  GLU   C CB    1 
ATOM   3753 C CG    . GLU   A 1 636  ? 117.978 170.820 153.786 1.00 16.64  ?  636  GLU   C CG    1 
ATOM   3754 C CD    . GLU   A 1 636  ? 116.716 171.069 153.021 1.00 22.35  ?  636  GLU   C CD    1 
ATOM   3755 O OE1   . GLU   A 1 636  ? 115.769 171.523 153.626 1.00 20.02  ?  636  GLU   C OE1   1 
ATOM   3756 O OE2   . GLU   A 1 636  ? 116.694 170.841 151.830 1.00 22.38  -1 636  GLU   C OE2   1 
ATOM   3757 N N     . MET   A 1 637  ? 120.275 174.938 154.287 1.00 16.11  ?  637  MET   C N     1 
ATOM   3758 C CA    . MET   A 1 637  ? 120.396 176.308 154.740 1.00 19.26  ?  637  MET   C CA    1 
ATOM   3759 C C     . MET   A 1 637  ? 121.332 177.030 153.787 1.00 21.86  ?  637  MET   C C     1 
ATOM   3760 O O     . MET   A 1 637  ? 122.470 176.625 153.579 1.00 21.66  ?  637  MET   C O     1 
ATOM   3761 C CB    . MET   A 1 637  ? 120.865 176.375 156.186 1.00 20.19  ?  637  MET   C CB    1 
ATOM   3762 C CG    . MET   A 1 637  ? 122.271 175.936 156.439 1.00 18.89  ?  637  MET   C CG    1 
ATOM   3763 S SD    . MET   A 1 637  ? 122.629 175.837 158.195 1.00 28.61  ?  637  MET   C SD    1 
ATOM   3764 C CE    . MET   A 1 637  ? 122.413 177.532 158.740 1.00 31.40  ?  637  MET   C CE    1 
ATOM   3765 N N     . GLN   A 1 638  ? 120.845 178.100 153.194 1.00 23.56  ?  638  GLN   C N     1 
ATOM   3766 C CA    . GLN   A 1 638  ? 121.590 178.791 152.155 1.00 25.23  ?  638  GLN   C CA    1 
ATOM   3767 C C     . GLN   A 1 638  ? 122.463 179.902 152.711 1.00 29.23  ?  638  GLN   C C     1 
ATOM   3768 O O     . GLN   A 1 638  ? 123.070 180.662 151.957 1.00 31.96  ?  638  GLN   C O     1 
ATOM   3769 C CB    . GLN   A 1 638  ? 120.619 179.330 151.109 1.00 32.45  ?  638  GLN   C CB    1 
ATOM   3770 C CG    . GLN   A 1 638  ? 119.860 178.236 150.346 1.00 25.41  ?  638  GLN   C CG    1 
ATOM   3771 C CD    . GLN   A 1 638  ? 120.725 177.525 149.310 1.00 25.68  ?  638  GLN   C CD    1 
ATOM   3772 O OE1   . GLN   A 1 638  ? 121.175 178.161 148.352 1.00 27.31  ?  638  GLN   C OE1   1 
ATOM   3773 N NE2   . GLN   A 1 638  ? 120.964 176.232 149.485 1.00 20.16  ?  638  GLN   C NE2   1 
ATOM   3774 N N     . GLU   A 1 639  ? 122.526 179.997 154.029 1.00 30.46  ?  639  GLU   C N     1 
ATOM   3775 C CA    . GLU   A 1 639  ? 123.312 181.034 154.670 1.00 33.38  ?  639  GLU   C CA    1 
ATOM   3776 C C     . GLU   A 1 639  ? 124.797 180.748 154.506 1.00 30.78  ?  639  GLU   C C     1 
ATOM   3777 O O     . GLU   A 1 639  ? 125.347 179.851 155.147 1.00 30.72  ?  639  GLU   C O     1 
ATOM   3778 C CB    . GLU   A 1 639  ? 122.946 181.117 156.152 1.00 36.20  ?  639  GLU   C CB    1 
ATOM   3779 C CG    . GLU   A 1 639  ? 123.621 182.238 156.916 1.00 40.71  ?  639  GLU   C CG    1 
ATOM   3780 C CD    . GLU   A 1 639  ? 123.148 182.334 158.346 1.00 53.31  ?  639  GLU   C CD    1 
ATOM   3781 O OE1   . GLU   A 1 639  ? 122.401 181.478 158.763 1.00 52.06  ?  639  GLU   C OE1   1 
ATOM   3782 O OE2   . GLU   A 1 639  ? 123.523 183.263 159.020 1.00 51.83  -1 639  GLU   C OE2   1 
ATOM   3783 N N     . GLU   A 1 640  ? 125.448 181.539 153.658 1.00 30.20  ?  640  GLU   C N     1 
ATOM   3784 C CA    . GLU   A 1 640  ? 126.847 181.326 153.312 1.00 30.83  ?  640  GLU   C CA    1 
ATOM   3785 C C     . GLU   A 1 640  ? 127.750 181.420 154.526 1.00 31.49  ?  640  GLU   C C     1 
ATOM   3786 O O     . GLU   A 1 640  ? 128.737 180.696 154.636 1.00 31.34  ?  640  GLU   C O     1 
ATOM   3787 C CB    . GLU   A 1 640  ? 127.293 182.345 152.265 1.00 36.14  ?  640  GLU   C CB    1 
ATOM   3788 C CG    . GLU   A 1 640  ? 126.685 182.138 150.888 1.00 40.55  ?  640  GLU   C CG    1 
ATOM   3789 C CD    . GLU   A 1 640  ? 127.099 183.198 149.904 1.00 44.21  ?  640  GLU   C CD    1 
ATOM   3790 O OE1   . GLU   A 1 640  ? 127.767 184.122 150.304 1.00 40.41  ?  640  GLU   C OE1   1 
ATOM   3791 O OE2   . GLU   A 1 640  ? 126.746 183.086 148.754 1.00 48.75  -1 640  GLU   C OE2   1 
ATOM   3792 N N     . ASP   A 1 641  ? 127.404 182.297 155.456 1.00 32.29  ?  641  ASP   C N     1 
ATOM   3793 C CA    . ASP   A 1 641  ? 128.219 182.481 156.644 1.00 32.39  ?  641  ASP   C CA    1 
ATOM   3794 C C     . ASP   A 1 641  ? 128.337 181.188 157.444 1.00 31.78  ?  641  ASP   C C     1 
ATOM   3795 O O     . ASP   A 1 641  ? 129.341 180.957 158.116 1.00 35.38  ?  641  ASP   C O     1 
ATOM   3796 C CB    . ASP   A 1 641  ? 127.635 183.584 157.524 1.00 41.24  ?  641  ASP   C CB    1 
ATOM   3797 C CG    . ASP   A 1 641  ? 127.812 184.976 156.927 1.00 56.48  ?  641  ASP   C CG    1 
ATOM   3798 O OD1   . ASP   A 1 641  ? 128.591 185.125 156.017 1.00 44.19  ?  641  ASP   C OD1   1 
ATOM   3799 O OD2   . ASP   A 1 641  ? 127.158 185.877 157.387 1.00 54.71  -1 641  ASP   C OD2   1 
ATOM   3800 N N     . PHE   A 1 642  ? 127.309 180.347 157.379 1.00 30.59  ?  642  PHE   C N     1 
ATOM   3801 C CA    . PHE   A 1 642  ? 127.326 179.076 158.081 1.00 27.45  ?  642  PHE   C CA    1 
ATOM   3802 C C     . PHE   A 1 642  ? 128.023 178.026 157.240 1.00 26.07  ?  642  PHE   C C     1 
ATOM   3803 O O     . PHE   A 1 642  ? 128.893 177.299 157.723 1.00 26.63  ?  642  PHE   C O     1 
ATOM   3804 C CB    . PHE   A 1 642  ? 125.904 178.603 158.365 1.00 29.01  ?  642  PHE   C CB    1 
ATOM   3805 C CG    . PHE   A 1 642  ? 125.813 177.316 159.142 1.00 26.11  ?  642  PHE   C CG    1 
ATOM   3806 C CD1   . PHE   A 1 642  ? 125.571 177.334 160.498 1.00 28.07  ?  642  PHE   C CD1   1 
ATOM   3807 C CD2   . PHE   A 1 642  ? 125.964 176.084 158.517 1.00 26.82  ?  642  PHE   C CD2   1 
ATOM   3808 C CE1   . PHE   A 1 642  ? 125.470 176.158 161.207 1.00 29.21  ?  642  PHE   C CE1   1 
ATOM   3809 C CE2   . PHE   A 1 642  ? 125.870 174.916 159.233 1.00 24.93  ?  642  PHE   C CE2   1 
ATOM   3810 C CZ    . PHE   A 1 642  ? 125.621 174.954 160.578 1.00 24.13  ?  642  PHE   C CZ    1 
ATOM   3811 N N     . VAL   A 1 643  ? 127.614 177.935 155.980 1.00 25.83  ?  643  VAL   C N     1 
ATOM   3812 C CA    . VAL   A 1 643  ? 128.085 176.876 155.105 1.00 23.76  ?  643  VAL   C CA    1 
ATOM   3813 C C     . VAL   A 1 643  ? 129.574 176.981 154.846 1.00 22.31  ?  643  VAL   C C     1 
ATOM   3814 O O     . VAL   A 1 643  ? 130.283 175.980 154.894 1.00 22.37  ?  643  VAL   C O     1 
ATOM   3815 C CB    . VAL   A 1 643  ? 127.312 176.895 153.775 1.00 21.51  ?  643  VAL   C CB    1 
ATOM   3816 C CG1   . VAL   A 1 643  ? 127.923 175.892 152.786 1.00 20.19  ?  643  VAL   C CG1   1 
ATOM   3817 C CG2   . VAL   A 1 643  ? 125.846 176.557 154.046 1.00 21.67  ?  643  VAL   C CG2   1 
ATOM   3818 N N     . GLN   A 1 644  ? 130.059 178.187 154.588 1.00 25.17  ?  644  GLN   C N     1 
ATOM   3819 C CA    . GLN   A 1 644  ? 131.472 178.357 154.300 1.00 23.91  ?  644  GLN   C CA    1 
ATOM   3820 C C     . GLN   A 1 644  ? 132.331 177.934 155.477 1.00 25.29  ?  644  GLN   C C     1 
ATOM   3821 O O     . GLN   A 1 644  ? 133.420 177.398 155.287 1.00 27.23  ?  644  GLN   C O     1 
ATOM   3822 C CB    . GLN   A 1 644  ? 131.762 179.798 153.887 1.00 25.28  ?  644  GLN   C CB    1 
ATOM   3823 C CG    . GLN   A 1 644  ? 131.207 180.122 152.513 1.00 27.19  ?  644  GLN   C CG    1 
ATOM   3824 C CD    . GLN   A 1 644  ? 131.387 181.547 152.085 1.00 37.40  ?  644  GLN   C CD    1 
ATOM   3825 O OE1   . GLN   A 1 644  ? 131.962 182.384 152.789 1.00 40.54  ?  644  GLN   C OE1   1 
ATOM   3826 N NE2   . GLN   A 1 644  ? 130.885 181.840 150.893 1.00 33.37  ?  644  GLN   C NE2   1 
ATOM   3827 N N     . ARG   A 1 645  ? 131.849 178.145 156.695 1.00 25.48  ?  645  ARG   C N     1 
ATOM   3828 C CA    . ARG   A 1 645  ? 132.602 177.707 157.857 1.00 24.99  ?  645  ARG   C CA    1 
ATOM   3829 C C     . ARG   A 1 645  ? 132.499 176.200 158.007 1.00 22.75  ?  645  ARG   C C     1 
ATOM   3830 O O     . ARG   A 1 645  ? 133.478 175.526 158.305 1.00 25.21  ?  645  ARG   C O     1 
ATOM   3831 C CB    . ARG   A 1 645  ? 132.106 178.395 159.117 1.00 28.02  ?  645  ARG   C CB    1 
ATOM   3832 C CG    . ARG   A 1 645  ? 132.267 179.913 159.122 1.00 31.34  ?  645  ARG   C CG    1 
ATOM   3833 C CD    . ARG   A 1 645  ? 133.693 180.333 159.338 1.00 39.55  ?  645  ARG   C CD    1 
ATOM   3834 N NE    . ARG   A 1 645  ? 134.506 180.178 158.130 1.00 38.25  ?  645  ARG   C NE    1 
ATOM   3835 C CZ    . ARG   A 1 645  ? 134.489 180.997 157.062 1.00 37.81  ?  645  ARG   C CZ    1 
ATOM   3836 N NH1   . ARG   A 1 645  ? 133.706 182.056 157.036 1.00 37.30  1  645  ARG   C NH1   1 
ATOM   3837 N NH2   . ARG   A 1 645  ? 135.266 180.714 156.034 1.00 36.88  ?  645  ARG   C NH2   1 
ATOM   3838 N N     . ALA   A 1 646  ? 131.316 175.660 157.760 1.00 22.80  ?  646  ALA   C N     1 
ATOM   3839 C CA    . ALA   A 1 646  ? 131.133 174.218 157.846 1.00 20.88  ?  646  ALA   C CA    1 
ATOM   3840 C C     . ALA   A 1 646  ? 132.003 173.501 156.821 1.00 21.14  ?  646  ALA   C C     1 
ATOM   3841 O O     . ALA   A 1 646  ? 132.519 172.409 157.082 1.00 21.97  ?  646  ALA   C O     1 
ATOM   3842 C CB    . ALA   A 1 646  ? 129.679 173.870 157.632 1.00 21.12  ?  646  ALA   C CB    1 
ATOM   3843 N N     . MET   A 1 647  ? 132.192 174.110 155.658 1.00 20.03  ?  647  MET   C N     1 
ATOM   3844 C CA    . MET   A 1 647  ? 132.979 173.480 154.617 1.00 17.71  ?  647  MET   C CA    1 
ATOM   3845 C C     . MET   A 1 647  ? 134.480 173.550 154.874 1.00 21.13  ?  647  MET   C C     1 
ATOM   3846 O O     . MET   A 1 647  ? 135.264 172.937 154.150 1.00 21.92  ?  647  MET   C O     1 
ATOM   3847 C CB    . MET   A 1 647  ? 132.649 174.051 153.250 1.00 17.63  ?  647  MET   C CB    1 
ATOM   3848 C CG    . MET   A 1 647  ? 131.278 173.649 152.719 1.00 17.22  ?  647  MET   C CG    1 
ATOM   3849 S SD    . MET   A 1 647  ? 131.020 171.850 152.698 1.00 16.23  ?  647  MET   C SD    1 
ATOM   3850 C CE    . MET   A 1 647  ? 132.161 171.289 151.458 1.00 15.96  ?  647  MET   C CE    1 
ATOM   3851 N N     . ASP   A 1 648  ? 134.889 174.252 155.927 1.00 23.64  ?  648  ASP   C N     1 
ATOM   3852 C CA    . ASP   A 1 648  ? 136.305 174.388 156.243 1.00 19.88  ?  648  ASP   C CA    1 
ATOM   3853 C C     . ASP   A 1 648  ? 136.811 173.163 156.978 1.00 22.20  ?  648  ASP   C C     1 
ATOM   3854 O O     . ASP   A 1 648  ? 137.974 173.102 157.371 1.00 24.37  ?  648  ASP   C O     1 
ATOM   3855 C CB    . ASP   A 1 648  ? 136.581 175.634 157.093 1.00 23.27  ?  648  ASP   C CB    1 
ATOM   3856 C CG    . ASP   A 1 648  ? 136.479 176.952 156.321 1.00 33.66  ?  648  ASP   C CG    1 
ATOM   3857 O OD1   . ASP   A 1 648  ? 136.653 176.934 155.123 1.00 31.64  ?  648  ASP   C OD1   1 
ATOM   3858 O OD2   . ASP   A 1 648  ? 136.244 177.972 156.942 1.00 33.48  -1 648  ASP   C OD2   1 
ATOM   3859 N N     . TYR   A 1 649  ? 135.941 172.180 157.156 1.00 21.77  ?  649  TYR   C N     1 
ATOM   3860 C CA    . TYR   A 1 649  ? 136.323 170.946 157.816 1.00 20.38  ?  649  TYR   C CA    1 
ATOM   3861 C C     . TYR   A 1 649  ? 136.467 169.793 156.831 1.00 19.47  ?  649  TYR   C C     1 
ATOM   3862 O O     . TYR   A 1 649  ? 136.619 168.645 157.243 1.00 21.13  ?  649  TYR   C O     1 
ATOM   3863 C CB    . TYR   A 1 649  ? 135.299 170.593 158.886 1.00 21.89  ?  649  TYR   C CB    1 
ATOM   3864 C CG    . TYR   A 1 649  ? 135.096 171.697 159.892 1.00 26.29  ?  649  TYR   C CG    1 
ATOM   3865 C CD1   . TYR   A 1 649  ? 133.853 172.285 160.024 1.00 26.05  ?  649  TYR   C CD1   1 
ATOM   3866 C CD2   . TYR   A 1 649  ? 136.151 172.135 160.671 1.00 27.08  ?  649  TYR   C CD2   1 
ATOM   3867 C CE1   . TYR   A 1 649  ? 133.663 173.303 160.929 1.00 27.05  ?  649  TYR   C CE1   1 
ATOM   3868 C CE2   . TYR   A 1 649  ? 135.959 173.153 161.579 1.00 27.37  ?  649  TYR   C CE2   1 
ATOM   3869 C CZ    . TYR   A 1 649  ? 134.719 173.735 161.708 1.00 26.78  ?  649  TYR   C CZ    1 
ATOM   3870 O OH    . TYR   A 1 649  ? 134.526 174.752 162.610 1.00 33.93  ?  649  TYR   C OH    1 
ATOM   3871 N N     . PHE   A 1 650  ? 136.460 170.095 155.531 1.00 20.20  ?  650  PHE   C N     1 
ATOM   3872 C CA    . PHE   A 1 650  ? 136.565 169.045 154.520 1.00 19.75  ?  650  PHE   C CA    1 
ATOM   3873 C C     . PHE   A 1 650  ? 137.732 169.230 153.553 1.00 18.85  ?  650  PHE   C C     1 
ATOM   3874 O O     . PHE   A 1 650  ? 137.519 169.664 152.425 1.00 19.48  ?  650  PHE   C O     1 
ATOM   3875 C CB    . PHE   A 1 650  ? 135.301 168.973 153.678 1.00 18.72  ?  650  PHE   C CB    1 
ATOM   3876 C CG    . PHE   A 1 650  ? 134.071 168.693 154.431 1.00 20.01  ?  650  PHE   C CG    1 
ATOM   3877 C CD1   . PHE   A 1 650  ? 133.267 169.715 154.799 1.00 20.52  ?  650  PHE   C CD1   1 
ATOM   3878 C CD2   . PHE   A 1 650  ? 133.709 167.412 154.759 1.00 20.29  ?  650  PHE   C CD2   1 
ATOM   3879 C CE1   . PHE   A 1 650  ? 132.101 169.500 155.486 1.00 19.75  ?  650  PHE   C CE1   1 
ATOM   3880 C CE2   . PHE   A 1 650  ? 132.544 167.172 155.442 1.00 18.71  ?  650  PHE   C CE2   1 
ATOM   3881 C CZ    . PHE   A 1 650  ? 131.736 168.225 155.807 1.00 20.32  ?  650  PHE   C CZ    1 
ATOM   3882 N N     . PRO   A 1 651  ? 138.971 168.945 153.973 1.00 19.49  ?  651  PRO   C N     1 
ATOM   3883 C CA    . PRO   A 1 651  ? 140.168 168.999 153.157 1.00 19.46  ?  651  PRO   C CA    1 
ATOM   3884 C C     . PRO   A 1 651  ? 140.134 167.926 152.075 1.00 16.54  ?  651  PRO   C C     1 
ATOM   3885 O O     . PRO   A 1 651  ? 140.793 168.045 151.039 1.00 17.25  ?  651  PRO   C O     1 
ATOM   3886 C CB    . PRO   A 1 651  ? 141.279 168.747 154.182 1.00 21.63  ?  651  PRO   C CB    1 
ATOM   3887 C CG    . PRO   A 1 651  ? 140.603 168.006 155.314 1.00 20.23  ?  651  PRO   C CG    1 
ATOM   3888 C CD    . PRO   A 1 651  ? 139.200 168.550 155.361 1.00 19.64  ?  651  PRO   C CD    1 
ATOM   3889 N N     . LYS   A 1 652  ? 139.343 166.889 152.312 1.00 16.68  ?  652  LYS   C N     1 
ATOM   3890 C CA    . LYS   A 1 652  ? 139.198 165.799 151.366 1.00 13.34  ?  652  LYS   C CA    1 
ATOM   3891 C C     . LYS   A 1 652  ? 137.739 165.409 151.249 1.00 13.32  ?  652  LYS   C C     1 
ATOM   3892 O O     . LYS   A 1 652  ? 137.083 165.129 152.252 1.00 18.28  ?  652  LYS   C O     1 
ATOM   3893 C CB    . LYS   A 1 652  ? 140.038 164.600 151.798 1.00 14.20  ?  652  LYS   C CB    1 
ATOM   3894 C CG    . LYS   A 1 652  ? 140.000 163.427 150.837 1.00 19.90  ?  652  LYS   C CG    1 
ATOM   3895 C CD    . LYS   A 1 652  ? 140.914 162.305 151.300 1.00 29.05  ?  652  LYS   C CD    1 
ATOM   3896 C CE    . LYS   A 1 652  ? 140.832 161.112 150.368 1.00 29.87  ?  652  LYS   C CE    1 
ATOM   3897 N NZ    . LYS   A 1 652  ? 141.703 159.995 150.819 1.00 32.97  1  652  LYS   C NZ    1 
ATOM   3898 N N     . ILE   A 1 653  ? 137.230 165.403 150.029 1.00 12.53  ?  653  ILE   C N     1 
ATOM   3899 C CA    . ILE   A 1 653  ? 135.835 165.071 149.792 1.00 10.95  ?  653  ILE   C CA    1 
ATOM   3900 C C     . ILE   A 1 653  ? 135.693 163.852 148.900 1.00 8.80   ?  653  ILE   C C     1 
ATOM   3901 O O     . ILE   A 1 653  ? 136.143 163.860 147.760 1.00 11.89  ?  653  ILE   C O     1 
ATOM   3902 C CB    . ILE   A 1 653  ? 135.101 166.264 149.157 1.00 9.20   ?  653  ILE   C CB    1 
ATOM   3903 C CG1   . ILE   A 1 653  ? 135.140 167.458 150.119 1.00 12.10  ?  653  ILE   C CG1   1 
ATOM   3904 C CG2   . ILE   A 1 653  ? 133.671 165.882 148.789 1.00 10.80  ?  653  ILE   C CG2   1 
ATOM   3905 C CD1   . ILE   A 1 653  ? 134.615 168.757 149.536 1.00 12.86  ?  653  ILE   C CD1   1 
ATOM   3906 N N     . GLU   A 1 654  ? 135.040 162.817 149.408 1.00 10.40  ?  654  GLU   C N     1 
ATOM   3907 C CA    . GLU   A 1 654  ? 134.781 161.624 148.612 1.00 10.55  ?  654  GLU   C CA    1 
ATOM   3908 C C     . GLU   A 1 654  ? 133.295 161.316 148.589 1.00 12.54  ?  654  GLU   C C     1 
ATOM   3909 O O     . GLU   A 1 654  ? 132.712 160.960 149.610 1.00 16.44  ?  654  GLU   C O     1 
ATOM   3910 C CB    . GLU   A 1 654  ? 135.554 160.428 149.158 1.00 10.31  ?  654  GLU   C CB    1 
ATOM   3911 C CG    . GLU   A 1 654  ? 135.362 159.151 148.358 1.00 17.03  ?  654  GLU   C CG    1 
ATOM   3912 C CD    . GLU   A 1 654  ? 136.177 158.006 148.879 1.00 32.92  ?  654  GLU   C CD    1 
ATOM   3913 O OE1   . GLU   A 1 654  ? 137.359 158.174 149.057 1.00 35.52  ?  654  GLU   C OE1   1 
ATOM   3914 O OE2   . GLU   A 1 654  ? 135.615 156.956 149.107 1.00 31.31  -1 654  GLU   C OE2   1 
ATOM   3915 N N     . ILE   A 1 655  ? 132.680 161.486 147.427 1.00 10.81  ?  655  ILE   C N     1 
ATOM   3916 C CA    . ILE   A 1 655  ? 131.236 161.311 147.304 1.00 10.02  ?  655  ILE   C CA    1 
ATOM   3917 C C     . ILE   A 1 655  ? 130.840 160.493 146.077 1.00 10.01  ?  655  ILE   C C     1 
ATOM   3918 O O     . ILE   A 1 655  ? 131.580 160.428 145.099 1.00 12.53  ?  655  ILE   C O     1 
ATOM   3919 C CB    . ILE   A 1 655  ? 130.544 162.688 147.304 1.00 8.46   ?  655  ILE   C CB    1 
ATOM   3920 C CG1   . ILE   A 1 655  ? 131.100 163.550 146.163 1.00 10.35  ?  655  ILE   C CG1   1 
ATOM   3921 C CG2   . ILE   A 1 655  ? 130.712 163.361 148.654 1.00 11.57  ?  655  ILE   C CG2   1 
ATOM   3922 C CD1   . ILE   A 1 655  ? 130.476 164.921 146.051 1.00 10.47  ?  655  ILE   C CD1   1 
ATOM   3923 N N     . ASN   A 1 656  ? 129.652 159.892 146.141 1.00 10.76  ?  656  ASN   C N     1 
ATOM   3924 C CA    . ASN   A 1 656  ? 129.090 159.117 145.036 1.00 9.92   ?  656  ASN   C CA    1 
ATOM   3925 C C     . ASN   A 1 656  ? 127.728 159.666 144.649 1.00 10.62  ?  656  ASN   C C     1 
ATOM   3926 O O     . ASN   A 1 656  ? 126.796 159.650 145.447 1.00 15.10  ?  656  ASN   C O     1 
ATOM   3927 C CB    . ASN   A 1 656  ? 128.972 157.651 145.402 1.00 12.81  ?  656  ASN   C CB    1 
ATOM   3928 C CG    . ASN   A 1 656  ? 130.291 156.978 145.543 1.00 10.58  ?  656  ASN   C CG    1 
ATOM   3929 O OD1   . ASN   A 1 656  ? 130.936 156.636 144.548 1.00 15.73  ?  656  ASN   C OD1   1 
ATOM   3930 N ND2   . ASN   A 1 656  ? 130.715 156.776 146.761 1.00 16.94  ?  656  ASN   C ND2   1 
ATOM   3931 N N     . LEU   A 1 657  ? 127.632 160.177 143.430 1.00 12.25  ?  657  LEU   C N     1 
ATOM   3932 C CA    . LEU   A 1 657  ? 126.414 160.826 142.967 1.00 9.62   ?  657  LEU   C CA    1 
ATOM   3933 C C     . LEU   A 1 657  ? 125.607 159.887 142.078 1.00 13.26  ?  657  LEU   C C     1 
ATOM   3934 O O     . LEU   A 1 657  ? 126.141 159.318 141.129 1.00 17.75  ?  657  LEU   C O     1 
ATOM   3935 C CB    . LEU   A 1 657  ? 126.803 162.082 142.181 1.00 9.82   ?  657  LEU   C CB    1 
ATOM   3936 C CG    . LEU   A 1 657  ? 127.810 163.007 142.885 1.00 9.99   ?  657  LEU   C CG    1 
ATOM   3937 C CD1   . LEU   A 1 657  ? 128.197 164.134 141.955 1.00 11.65  ?  657  LEU   C CD1   1 
ATOM   3938 C CD2   . LEU   A 1 657  ? 127.202 163.559 144.134 1.00 11.12  ?  657  LEU   C CD2   1 
ATOM   3939 N N     . SER   A 1 658  ? 124.317 159.725 142.387 1.00 14.59  ?  658  SER   C N     1 
ATOM   3940 C CA    . SER   A 1 658  ? 123.471 158.847 141.581 1.00 16.20  ?  658  SER   C CA    1 
ATOM   3941 C C     . SER   A 1 658  ? 122.360 159.606 140.880 1.00 12.71  ?  658  SER   C C     1 
ATOM   3942 O O     . SER   A 1 658  ? 121.854 159.167 139.846 1.00 19.66  ?  658  SER   C O     1 
ATOM   3943 C CB    . SER   A 1 658  ? 122.852 157.772 142.446 1.00 16.71  ?  658  SER   C CB    1 
ATOM   3944 O OG    . SER   A 1 658  ? 121.993 158.325 143.398 1.00 20.06  ?  658  SER   C OG    1 
ATOM   3945 N N     . THR   A 1 659  ? 121.982 160.752 141.422 1.00 12.42  ?  659  THR   C N     1 
ATOM   3946 C CA    . THR   A 1 659  ? 120.908 161.519 140.810 1.00 11.80  ?  659  THR   C CA    1 
ATOM   3947 C C     . THR   A 1 659  ? 121.235 162.990 140.637 1.00 11.61  ?  659  THR   C C     1 
ATOM   3948 O O     . THR   A 1 659  ? 122.300 163.465 141.038 1.00 11.98  ?  659  THR   C O     1 
ATOM   3949 C CB    . THR   A 1 659  ? 119.588 161.362 141.582 1.00 12.38  ?  659  THR   C CB    1 
ATOM   3950 O OG1   . THR   A 1 659  ? 118.536 161.964 140.816 1.00 18.06  ?  659  THR   C OG1   1 
ATOM   3951 C CG2   . THR   A 1 659  ? 119.661 162.002 142.949 1.00 10.81  ?  659  THR   C CG2   1 
ATOM   3952 N N     . ARG   A 1 660  ? 120.314 163.711 140.015 1.00 12.34  ?  660  ARG   C N     1 
ATOM   3953 C CA    . ARG   A 1 660  ? 120.513 165.122 139.727 1.00 11.06  ?  660  ARG   C CA    1 
ATOM   3954 C C     . ARG   A 1 660  ? 120.555 165.946 140.999 1.00 11.35  ?  660  ARG   C C     1 
ATOM   3955 O O     . ARG   A 1 660  ? 121.295 166.924 141.092 1.00 13.53  ?  660  ARG   C O     1 
ATOM   3956 C CB    . ARG   A 1 660  ? 119.420 165.643 138.815 1.00 17.00  ?  660  ARG   C CB    1 
ATOM   3957 C CG    . ARG   A 1 660  ? 119.622 167.064 138.339 1.00 20.83  ?  660  ARG   C CG    1 
ATOM   3958 C CD    . ARG   A 1 660  ? 118.592 167.459 137.355 1.00 26.91  ?  660  ARG   C CD    1 
ATOM   3959 N NE    . ARG   A 1 660  ? 118.704 168.860 136.989 1.00 35.26  ?  660  ARG   C NE    1 
ATOM   3960 C CZ    . ARG   A 1 660  ? 119.572 169.353 136.077 1.00 37.10  ?  660  ARG   C CZ    1 
ATOM   3961 N NH1   . ARG   A 1 660  ? 120.407 168.548 135.450 1.00 43.03  1  660  ARG   C NH1   1 
ATOM   3962 N NH2   . ARG   A 1 660  ? 119.586 170.645 135.810 1.00 33.45  ?  660  ARG   C NH2   1 
ATOM   3963 N N     . MET   A 1 661  ? 119.752 165.553 141.977 1.00 11.75  ?  661  MET   C N     1 
ATOM   3964 C CA    . MET   A 1 661  ? 119.703 166.260 143.246 1.00 10.38  ?  661  MET   C CA    1 
ATOM   3965 C C     . MET   A 1 661  ? 121.028 166.144 143.988 1.00 9.72   ?  661  MET   C C     1 
ATOM   3966 O O     . MET   A 1 661  ? 121.443 167.078 144.670 1.00 10.99  ?  661  MET   C O     1 
ATOM   3967 C CB    . MET   A 1 661  ? 118.550 165.746 144.087 1.00 12.31  ?  661  MET   C CB    1 
ATOM   3968 C CG    . MET   A 1 661  ? 118.372 166.472 145.398 1.00 13.08  ?  661  MET   C CG    1 
ATOM   3969 S SD    . MET   A 1 661  ? 116.859 166.013 146.253 1.00 16.78  ?  661  MET   C SD    1 
ATOM   3970 C CE    . MET   A 1 661  ? 117.204 164.328 146.774 1.00 18.22  ?  661  MET   C CE    1 
ATOM   3971 N N     . ASP   A 1 662  ? 121.703 165.005 143.837 1.00 11.23  ?  662  ASP   C N     1 
ATOM   3972 C CA    . ASP   A 1 662  ? 122.994 164.795 144.477 1.00 8.59   ?  662  ASP   C CA    1 
ATOM   3973 C C     . ASP   A 1 662  ? 124.002 165.780 143.918 1.00 10.64  ?  662  ASP   C C     1 
ATOM   3974 O O     . ASP   A 1 662  ? 124.849 166.303 144.645 1.00 12.17  ?  662  ASP   C O     1 
ATOM   3975 C CB    . ASP   A 1 662  ? 123.518 163.385 144.211 1.00 8.53   ?  662  ASP   C CB    1 
ATOM   3976 C CG    . ASP   A 1 662  ? 122.779 162.282 144.888 1.00 11.14  ?  662  ASP   C CG    1 
ATOM   3977 O OD1   . ASP   A 1 662  ? 122.176 162.497 145.910 1.00 13.46  ?  662  ASP   C OD1   1 
ATOM   3978 O OD2   . ASP   A 1 662  ? 122.800 161.200 144.346 1.00 12.41  -1 662  ASP   C OD2   1 
ATOM   3979 N N     . HIS   A 1 663  ? 123.902 166.034 142.615 1.00 10.84  ?  663  HIS   C N     1 
ATOM   3980 C CA    . HIS   A 1 663  ? 124.806 166.957 141.949 1.00 9.47   ?  663  HIS   C CA    1 
ATOM   3981 C C     . HIS   A 1 663  ? 124.520 168.383 142.379 1.00 10.92  ?  663  HIS   C C     1 
ATOM   3982 O O     . HIS   A 1 663  ? 125.442 169.149 142.656 1.00 14.31  ?  663  HIS   C O     1 
ATOM   3983 C CB    . HIS   A 1 663  ? 124.667 166.864 140.427 1.00 12.17  ?  663  HIS   C CB    1 
ATOM   3984 C CG    . HIS   A 1 663  ? 125.243 165.631 139.817 1.00 10.52  ?  663  HIS   C CG    1 
ATOM   3985 N ND1   . HIS   A 1 663  ? 124.597 164.421 139.838 1.00 11.17  ?  663  HIS   C ND1   1 
ATOM   3986 C CD2   . HIS   A 1 663  ? 126.402 165.427 139.158 1.00 14.67  ?  663  HIS   C CD2   1 
ATOM   3987 C CE1   . HIS   A 1 663  ? 125.331 163.524 139.218 1.00 14.73  ?  663  HIS   C CE1   1 
ATOM   3988 N NE2   . HIS   A 1 663  ? 126.435 164.106 138.796 1.00 17.92  ?  663  HIS   C NE2   1 
ATOM   3989 N N     . MET   A 1 664  ? 123.242 168.733 142.460 1.00 10.69  ?  664  MET   C N     1 
ATOM   3990 C CA    . MET   A 1 664  ? 122.840 170.076 142.857 1.00 10.49  ?  664  MET   C CA    1 
ATOM   3991 C C     . MET   A 1 664  ? 123.375 170.418 144.235 1.00 10.49  ?  664  MET   C C     1 
ATOM   3992 O O     . MET   A 1 664  ? 123.896 171.512 144.464 1.00 13.03  ?  664  MET   C O     1 
ATOM   3993 C CB    . MET   A 1 664  ? 121.323 170.177 142.832 1.00 11.93  ?  664  MET   C CB    1 
ATOM   3994 C CG    . MET   A 1 664  ? 120.761 171.514 143.274 1.00 16.80  ?  664  MET   C CG    1 
ATOM   3995 S SD    . MET   A 1 664  ? 118.967 171.566 143.189 1.00 20.94  ?  664  MET   C SD    1 
ATOM   3996 C CE    . MET   A 1 664  ? 118.501 170.575 144.599 1.00 16.96  ?  664  MET   C CE    1 
ATOM   3997 N N     . VAL   A 1 665  ? 123.245 169.468 145.143 1.00 11.27  ?  665  VAL   C N     1 
ATOM   3998 C CA    . VAL   A 1 665  ? 123.713 169.609 146.506 1.00 10.68  ?  665  VAL   C CA    1 
ATOM   3999 C C     . VAL   A 1 665  ? 125.231 169.663 146.586 1.00 11.81  ?  665  VAL   C C     1 
ATOM   4000 O O     . VAL   A 1 665  ? 125.794 170.496 147.300 1.00 12.77  ?  665  VAL   C O     1 
ATOM   4001 C CB    . VAL   A 1 665  ? 123.158 168.444 147.337 1.00 9.17   ?  665  VAL   C CB    1 
ATOM   4002 C CG1   . VAL   A 1 665  ? 123.812 168.381 148.679 1.00 11.28  ?  665  VAL   C CG1   1 
ATOM   4003 C CG2   . VAL   A 1 665  ? 121.666 168.641 147.494 1.00 10.42  ?  665  VAL   C CG2   1 
ATOM   4004 N N     . SER   A 1 666  ? 125.894 168.781 145.848 1.00 12.50  ?  666  SER   C N     1 
ATOM   4005 C CA    . SER   A 1 666  ? 127.344 168.722 145.859 1.00 10.27  ?  666  SER   C CA    1 
ATOM   4006 C C     . SER   A 1 666  ? 127.956 169.992 145.293 1.00 13.20  ?  666  SER   C C     1 
ATOM   4007 O O     . SER   A 1 666  ? 128.938 170.503 145.832 1.00 15.41  ?  666  SER   C O     1 
ATOM   4008 C CB    . SER   A 1 666  ? 127.810 167.530 145.061 1.00 9.45   ?  666  SER   C CB    1 
ATOM   4009 O OG    . SER   A 1 666  ? 127.381 166.346 145.659 1.00 11.62  ?  666  SER   C OG    1 
ATOM   4010 N N     . SER   A 1 667  ? 127.366 170.525 144.226 1.00 12.72  ?  667  SER   C N     1 
ATOM   4011 C CA    . SER   A 1 667  ? 127.888 171.739 143.621 1.00 12.31  ?  667  SER   C CA    1 
ATOM   4012 C C     . SER   A 1 667  ? 127.797 172.899 144.591 1.00 14.82  ?  667  SER   C C     1 
ATOM   4013 O O     . SER   A 1 667  ? 128.756 173.647 144.763 1.00 18.14  ?  667  SER   C O     1 
ATOM   4014 C CB    . SER   A 1 667  ? 127.113 172.080 142.365 1.00 14.84  ?  667  SER   C CB    1 
ATOM   4015 O OG    . SER   A 1 667  ? 127.307 171.119 141.368 1.00 17.66  ?  667  SER   C OG    1 
ATOM   4016 N N     . PHE   A 1 668  ? 126.660 173.027 145.265 1.00 15.09  ?  668  PHE   C N     1 
ATOM   4017 C CA    . PHE   A 1 668  ? 126.470 174.105 146.223 1.00 14.69  ?  668  PHE   C CA    1 
ATOM   4018 C C     . PHE   A 1 668  ? 127.538 174.089 147.300 1.00 15.41  ?  668  PHE   C C     1 
ATOM   4019 O O     . PHE   A 1 668  ? 128.129 175.119 147.629 1.00 18.34  ?  668  PHE   C O     1 
ATOM   4020 C CB    . PHE   A 1 668  ? 125.100 174.002 146.877 1.00 15.06  ?  668  PHE   C CB    1 
ATOM   4021 C CG    . PHE   A 1 668  ? 124.900 174.960 148.006 1.00 16.86  ?  668  PHE   C CG    1 
ATOM   4022 C CD1   . PHE   A 1 668  ? 124.635 176.291 147.769 1.00 18.30  ?  668  PHE   C CD1   1 
ATOM   4023 C CD2   . PHE   A 1 668  ? 124.977 174.525 149.314 1.00 16.12  ?  668  PHE   C CD2   1 
ATOM   4024 C CE1   . PHE   A 1 668  ? 124.453 177.166 148.814 1.00 20.12  ?  668  PHE   C CE1   1 
ATOM   4025 C CE2   . PHE   A 1 668  ? 124.793 175.394 150.356 1.00 16.08  ?  668  PHE   C CE2   1 
ATOM   4026 C CZ    . PHE   A 1 668  ? 124.532 176.716 150.107 1.00 19.74  ?  668  PHE   C CZ    1 
ATOM   4027 N N     . CYS   A 1 669  ? 127.767 172.922 147.882 1.00 15.82  ?  669  CYS   C N     1 
ATOM   4028 C CA    . CYS   A 1 669  ? 128.741 172.824 148.951 1.00 13.51  ?  669  CYS   C CA    1 
ATOM   4029 C C     . CYS   A 1 669  ? 130.162 173.063 148.462 1.00 15.40  ?  669  CYS   C C     1 
ATOM   4030 O O     . CYS   A 1 669  ? 130.922 173.798 149.090 1.00 18.60  ?  669  CYS   C O     1 
ATOM   4031 C CB    . CYS   A 1 669  ? 128.642 171.463 149.620 1.00 15.38  ?  669  CYS   C CB    1 
ATOM   4032 S SG    . CYS   A 1 669  ? 127.144 171.268 150.576 1.00 15.67  ?  669  CYS   C SG    1 
ATOM   4033 N N     . ILE   A 1 670  ? 130.524 172.473 147.330 1.00 16.10  ?  670  ILE   C N     1 
ATOM   4034 C CA    . ILE   A 1 670  ? 131.874 172.626 146.801 1.00 15.27  ?  670  ILE   C CA    1 
ATOM   4035 C C     . ILE   A 1 670  ? 132.162 174.074 146.421 1.00 16.06  ?  670  ILE   C C     1 
ATOM   4036 O O     . ILE   A 1 670  ? 133.255 174.576 146.673 1.00 20.36  ?  670  ILE   C O     1 
ATOM   4037 C CB    . ILE   A 1 670  ? 132.127 171.671 145.624 1.00 15.25  ?  670  ILE   C CB    1 
ATOM   4038 C CG1   . ILE   A 1 670  ? 132.158 170.222 146.161 1.00 13.38  ?  670  ILE   C CG1   1 
ATOM   4039 C CG2   . ILE   A 1 670  ? 133.447 172.019 144.932 1.00 16.74  ?  670  ILE   C CG2   1 
ATOM   4040 C CD1   . ILE   A 1 670  ? 132.070 169.153 145.097 1.00 12.18  ?  670  ILE   C CD1   1 
ATOM   4041 N N     . GLU   A 1 671  ? 131.181 174.762 145.847 1.00 15.73  ?  671  GLU   C N     1 
ATOM   4042 C CA    . GLU   A 1 671  ? 131.348 176.166 145.477 1.00 15.98  ?  671  GLU   C CA    1 
ATOM   4043 C C     . GLU   A 1 671  ? 131.753 177.025 146.668 1.00 18.44  ?  671  GLU   C C     1 
ATOM   4044 O O     . GLU   A 1 671  ? 132.368 178.077 146.497 1.00 23.49  ?  671  GLU   C O     1 
ATOM   4045 C CB    . GLU   A 1 671  ? 130.052 176.744 144.894 1.00 17.69  ?  671  GLU   C CB    1 
ATOM   4046 C CG    . GLU   A 1 671  ? 129.718 176.331 143.468 1.00 21.12  ?  671  GLU   C CG    1 
ATOM   4047 C CD    . GLU   A 1 671  ? 128.350 176.796 143.027 1.00 27.71  ?  671  GLU   C CD    1 
ATOM   4048 O OE1   . GLU   A 1 671  ? 127.648 177.363 143.829 1.00 27.02  ?  671  GLU   C OE1   1 
ATOM   4049 O OE2   . GLU   A 1 671  ? 128.009 176.582 141.887 1.00 25.40  -1 671  GLU   C OE2   1 
ATOM   4050 N N     . ASN   A 1 672  ? 131.363 176.607 147.867 1.00 18.75  ?  672  ASN   C N     1 
ATOM   4051 C CA    . ASN   A 1 672  ? 131.622 177.374 149.073 1.00 18.54  ?  672  ASN   C CA    1 
ATOM   4052 C C     . ASN   A 1 672  ? 132.752 176.789 149.909 1.00 19.02  ?  672  ASN   C C     1 
ATOM   4053 O O     . ASN   A 1 672  ? 132.964 177.205 151.048 1.00 22.25  ?  672  ASN   C O     1 
ATOM   4054 C CB    . ASN   A 1 672  ? 130.347 177.473 149.888 1.00 20.16  ?  672  ASN   C CB    1 
ATOM   4055 C CG    . ASN   A 1 672  ? 129.347 178.406 149.271 1.00 23.37  ?  672  ASN   C CG    1 
ATOM   4056 O OD1   . ASN   A 1 672  ? 129.431 179.630 149.452 1.00 30.34  ?  672  ASN   C OD1   1 
ATOM   4057 N ND2   . ASN   A 1 672  ? 128.407 177.870 148.533 1.00 20.06  ?  672  ASN   C ND2   1 
ATOM   4058 N N     . CYS   A 1 673  ? 133.480 175.829 149.352 1.00 18.91  ?  673  CYS   C N     1 
ATOM   4059 C CA    . CYS   A 1 673  ? 134.561 175.191 150.085 1.00 17.75  ?  673  CYS   C CA    1 
ATOM   4060 C C     . CYS   A 1 673  ? 135.916 175.709 149.638 1.00 21.14  ?  673  CYS   C C     1 
ATOM   4061 O O     . CYS   A 1 673  ? 136.305 175.545 148.483 1.00 24.76  ?  673  CYS   C O     1 
ATOM   4062 C CB    . CYS   A 1 673  ? 134.524 173.684 149.893 1.00 15.84  ?  673  CYS   C CB    1 
ATOM   4063 S SG    . CYS   A 1 673  ? 135.748 172.801 150.876 1.00 18.28  ?  673  CYS   C SG    1 
ATOM   4064 N N     . HIS   A 1 674  ? 136.641 176.327 150.559 1.00 21.16  ?  674  HIS   C N     1 
ATOM   4065 C CA    . HIS   A 1 674  ? 137.928 176.919 150.232 1.00 20.58  ?  674  HIS   C CA    1 
ATOM   4066 C C     . HIS   A 1 674  ? 139.082 176.143 150.846 1.00 21.47  ?  674  HIS   C C     1 
ATOM   4067 O O     . HIS   A 1 674  ? 140.223 176.605 150.843 1.00 26.02  ?  674  HIS   C O     1 
ATOM   4068 C CB    . HIS   A 1 674  ? 137.957 178.368 150.707 1.00 23.63  ?  674  HIS   C CB    1 
ATOM   4069 C CG    . HIS   A 1 674  ? 136.887 179.187 150.079 1.00 23.94  ?  674  HIS   C CG    1 
ATOM   4070 N ND1   . HIS   A 1 674  ? 136.955 179.627 148.778 1.00 29.81  ?  674  HIS   C ND1   1 
ATOM   4071 C CD2   . HIS   A 1 674  ? 135.707 179.632 150.567 1.00 24.23  ?  674  HIS   C CD2   1 
ATOM   4072 C CE1   . HIS   A 1 674  ? 135.862 180.310 148.492 1.00 34.39  ?  674  HIS   C CE1   1 
ATOM   4073 N NE2   . HIS   A 1 674  ? 135.091 180.328 149.561 1.00 29.74  ?  674  HIS   C NE2   1 
ATOM   4074 N N     . ARG   A 1 675  ? 138.788 174.964 151.378 1.00 19.16  ?  675  ARG   C N     1 
ATOM   4075 C CA    . ARG   A 1 675  ? 139.818 174.144 151.999 1.00 20.06  ?  675  ARG   C CA    1 
ATOM   4076 C C     . ARG   A 1 675  ? 140.121 172.877 151.217 1.00 19.37  ?  675  ARG   C C     1 
ATOM   4077 O O     . ARG   A 1 675  ? 141.204 172.313 151.354 1.00 21.30  ?  675  ARG   C O     1 
ATOM   4078 C CB    . ARG   A 1 675  ? 139.436 173.746 153.416 1.00 21.38  ?  675  ARG   C CB    1 
ATOM   4079 C CG    . ARG   A 1 675  ? 140.517 172.942 154.142 1.00 23.30  ?  675  ARG   C CG    1 
ATOM   4080 C CD    . ARG   A 1 675  ? 140.168 172.630 155.534 1.00 23.36  ?  675  ARG   C CD    1 
ATOM   4081 N NE    . ARG   A 1 675  ? 141.206 171.831 156.170 1.00 28.13  ?  675  ARG   C NE    1 
ATOM   4082 C CZ    . ARG   A 1 675  ? 141.153 171.323 157.418 1.00 29.58  ?  675  ARG   C CZ    1 
ATOM   4083 N NH1   . ARG   A 1 675  ? 140.103 171.531 158.183 1.00 27.98  1  675  ARG   C NH1   1 
ATOM   4084 N NH2   . ARG   A 1 675  ? 142.170 170.609 157.873 1.00 29.34  ?  675  ARG   C NH2   1 
ATOM   4085 N N     . VAL   A 1 676  ? 139.162 172.387 150.445 1.00 19.13  ?  676  VAL   C N     1 
ATOM   4086 C CA    . VAL   A 1 676  ? 139.346 171.087 149.821 1.00 16.29  ?  676  VAL   C CA    1 
ATOM   4087 C C     . VAL   A 1 676  ? 140.583 171.065 148.951 1.00 16.31  ?  676  VAL   C C     1 
ATOM   4088 O O     . VAL   A 1 676  ? 140.765 171.917 148.085 1.00 18.81  ?  676  VAL   C O     1 
ATOM   4089 C CB    . VAL   A 1 676  ? 138.101 170.690 148.994 1.00 14.93  ?  676  VAL   C CB    1 
ATOM   4090 C CG1   . VAL   A 1 676  ? 137.875 171.658 147.829 1.00 14.59  ?  676  VAL   C CG1   1 
ATOM   4091 C CG2   . VAL   A 1 676  ? 138.276 169.267 148.472 1.00 15.32  ?  676  VAL   C CG2   1 
ATOM   4092 N N     . GLU   A 1 677  ? 141.424 170.070 149.183 1.00 16.86  ?  677  GLU   C N     1 
ATOM   4093 C CA    . GLU   A 1 677  ? 142.633 169.882 148.409 1.00 15.94  ?  677  GLU   C CA    1 
ATOM   4094 C C     . GLU   A 1 677  ? 142.467 168.699 147.479 1.00 12.47  ?  677  GLU   C C     1 
ATOM   4095 O O     . GLU   A 1 677  ? 143.002 168.689 146.370 1.00 13.96  ?  677  GLU   C O     1 
ATOM   4096 C CB    . GLU   A 1 677  ? 143.833 169.657 149.326 1.00 17.63  ?  677  GLU   C CB    1 
ATOM   4097 C CG    . GLU   A 1 677  ? 144.184 170.840 150.208 1.00 20.01  ?  677  GLU   C CG    1 
ATOM   4098 C CD    . GLU   A 1 677  ? 145.388 170.581 151.071 1.00 34.17  ?  677  GLU   C CD    1 
ATOM   4099 O OE1   . GLU   A 1 677  ? 145.883 169.479 151.046 1.00 36.06  ?  677  GLU   C OE1   1 
ATOM   4100 O OE2   . GLU   A 1 677  ? 145.816 171.483 151.753 1.00 31.23  -1 677  GLU   C OE2   1 
ATOM   4101 N N     . SER   A 1 678  ? 141.705 167.709 147.931 1.00 11.63  ?  678  SER   C N     1 
ATOM   4102 C CA    . SER   A 1 678  ? 141.499 166.494 147.160 1.00 9.88   ?  678  SER   C CA    1 
ATOM   4103 C C     . SER   A 1 678  ? 140.031 166.134 147.053 1.00 11.03  ?  678  SER   C C     1 
ATOM   4104 O O     . SER   A 1 678  ? 139.309 166.115 148.051 1.00 13.83  ?  678  SER   C O     1 
ATOM   4105 C CB    . SER   A 1 678  ? 142.258 165.345 147.781 1.00 13.11  ?  678  SER   C CB    1 
ATOM   4106 O OG    . SER   A 1 678  ? 141.981 164.150 147.109 1.00 16.52  ?  678  SER   C OG    1 
ATOM   4107 N N     . LEU   A 1 679  ? 139.590 165.882 145.832 1.00 9.71   ?  679  LEU   C N     1 
ATOM   4108 C CA    . LEU   A 1 679  ? 138.208 165.528 145.571 1.00 9.07   ?  679  LEU   C CA    1 
ATOM   4109 C C     . LEU   A 1 679  ? 138.099 164.254 144.760 1.00 7.51   ?  679  LEU   C C     1 
ATOM   4110 O O     . LEU   A 1 679  ? 138.752 164.112 143.727 1.00 10.05  ?  679  LEU   C O     1 
ATOM   4111 C CB    . LEU   A 1 679  ? 137.506 166.656 144.818 1.00 11.34  ?  679  LEU   C CB    1 
ATOM   4112 C CG    . LEU   A 1 679  ? 136.081 166.372 144.354 1.00 10.61  ?  679  LEU   C CG    1 
ATOM   4113 C CD1   . LEU   A 1 679  ? 135.160 166.249 145.533 1.00 11.11  ?  679  LEU   C CD1   1 
ATOM   4114 C CD2   . LEU   A 1 679  ? 135.648 167.467 143.478 1.00 12.73  ?  679  LEU   C CD2   1 
ATOM   4115 N N     . SER   A 1 680  ? 137.260 163.343 145.224 1.00 8.79   ?  680  SER   C N     1 
ATOM   4116 C CA    . SER   A 1 680  ? 136.988 162.102 144.522 1.00 7.83   ?  680  SER   C CA    1 
ATOM   4117 C C     . SER   A 1 680  ? 135.508 161.999 144.198 1.00 10.57  ?  680  SER   C C     1 
ATOM   4118 O O     . SER   A 1 680  ? 134.660 162.044 145.093 1.00 12.04  ?  680  SER   C O     1 
ATOM   4119 C CB    . SER   A 1 680  ? 137.427 160.921 145.357 1.00 8.01   ?  680  SER   C CB    1 
ATOM   4120 O OG    . SER   A 1 680  ? 137.065 159.716 144.746 1.00 13.88  ?  680  SER   C OG    1 
ATOM   4121 N N     . LEU   A 1 681  ? 135.193 161.919 142.911 1.00 10.76  ?  681  LEU   C N     1 
ATOM   4122 C CA    . LEU   A 1 681  ? 133.801 161.879 142.488 1.00 10.11  ?  681  LEU   C CA    1 
ATOM   4123 C C     . LEU   A 1 681  ? 133.443 160.577 141.818 1.00 11.64  ?  681  LEU   C C     1 
ATOM   4124 O O     . LEU   A 1 681  ? 133.914 160.278 140.722 1.00 15.91  ?  681  LEU   C O     1 
ATOM   4125 C CB    . LEU   A 1 681  ? 133.490 163.006 141.498 1.00 10.78  ?  681  LEU   C CB    1 
ATOM   4126 C CG    . LEU   A 1 681  ? 133.671 164.426 141.975 1.00 11.79  ?  681  LEU   C CG    1 
ATOM   4127 C CD1   . LEU   A 1 681  ? 133.464 165.355 140.804 1.00 12.80  ?  681  LEU   C CD1   1 
ATOM   4128 C CD2   . LEU   A 1 681  ? 132.675 164.721 143.072 1.00 15.61  ?  681  LEU   C CD2   1 
ATOM   4129 N N     . GLY   A 1 682  ? 132.570 159.822 142.459 1.00 11.56  ?  682  GLY   C N     1 
ATOM   4130 C CA    . GLY   A 1 682  ? 132.057 158.604 141.873 1.00 12.02  ?  682  GLY   C CA    1 
ATOM   4131 C C     . GLY   A 1 682  ? 130.759 158.924 141.157 1.00 13.19  ?  682  GLY   C C     1 
ATOM   4132 O O     . GLY   A 1 682  ? 130.064 159.878 141.513 1.00 13.64  ?  682  GLY   C O     1 
ATOM   4133 N N     . PHE   A 1 683  ? 130.422 158.128 140.159 1.00 17.02  ?  683  PHE   C N     1 
ATOM   4134 C CA    . PHE   A 1 683  ? 129.162 158.312 139.460 1.00 15.08  ?  683  PHE   C CA    1 
ATOM   4135 C C     . PHE   A 1 683  ? 128.461 156.983 139.285 1.00 21.43  ?  683  PHE   C C     1 
ATOM   4136 O O     . PHE   A 1 683  ? 129.038 156.024 138.774 1.00 27.65  ?  683  PHE   C O     1 
ATOM   4137 C CB    . PHE   A 1 683  ? 129.380 158.985 138.110 1.00 18.65  ?  683  PHE   C CB    1 
ATOM   4138 C CG    . PHE   A 1 683  ? 129.962 160.365 138.215 1.00 19.54  ?  683  PHE   C CG    1 
ATOM   4139 C CD1   . PHE   A 1 683  ? 131.322 160.562 138.154 1.00 20.49  ?  683  PHE   C CD1   1 
ATOM   4140 C CD2   . PHE   A 1 683  ? 129.147 161.466 138.379 1.00 18.91  ?  683  PHE   C CD2   1 
ATOM   4141 C CE1   . PHE   A 1 683  ? 131.859 161.821 138.253 1.00 19.54  ?  683  PHE   C CE1   1 
ATOM   4142 C CE2   . PHE   A 1 683  ? 129.683 162.729 138.474 1.00 20.69  ?  683  PHE   C CE2   1 
ATOM   4143 C CZ    . PHE   A 1 683  ? 131.041 162.907 138.410 1.00 20.70  ?  683  PHE   C CZ    1 
ATOM   4144 N N     . LEU   A 1 684  ? 127.220 156.930 139.727 1.00 23.34  ?  684  LEU   C N     1 
ATOM   4145 C CA    . LEU   A 1 684  ? 126.427 155.718 139.667 1.00 25.71  ?  684  LEU   C CA    1 
ATOM   4146 C C     . LEU   A 1 684  ? 125.385 155.841 138.568 1.00 32.17  ?  684  LEU   C C     1 
ATOM   4147 O O     . LEU   A 1 684  ? 125.156 156.931 138.045 1.00 28.97  ?  684  LEU   C O     1 
ATOM   4148 C CB    . LEU   A 1 684  ? 125.782 155.465 141.032 1.00 28.82  ?  684  LEU   C CB    1 
ATOM   4149 C CG    . LEU   A 1 684  ? 126.774 155.436 142.233 1.00 24.35  ?  684  LEU   C CG    1 
ATOM   4150 C CD1   . LEU   A 1 684  ? 126.002 155.266 143.530 1.00 26.56  ?  684  LEU   C CD1   1 
ATOM   4151 C CD2   . LEU   A 1 684  ? 127.774 154.301 142.056 1.00 28.53  ?  684  LEU   C CD2   1 
ATOM   4152 N N     . HIS   A 1 685  ? 124.770 154.728 138.194 1.00 37.60  ?  685  HIS   C N     1 
ATOM   4153 C CA    . HIS   A 1 685  ? 123.796 154.762 137.109 1.00 46.83  ?  685  HIS   C CA    1 
ATOM   4154 C C     . HIS   A 1 685  ? 122.719 155.800 137.421 1.00 44.15  ?  685  HIS   C C     1 
ATOM   4155 O O     . HIS   A 1 685  ? 122.148 155.795 138.514 1.00 38.42  ?  685  HIS   C O     1 
ATOM   4156 C CB    . HIS   A 1 685  ? 123.142 153.388 136.925 1.00 50.27  ?  685  HIS   C CB    1 
ATOM   4157 C CG    . HIS   A 1 685  ? 122.444 153.209 135.602 1.00 53.94  ?  685  HIS   C CG    1 
ATOM   4158 N ND1   . HIS   A 1 685  ? 121.377 153.991 135.198 1.00 53.39  ?  685  HIS   C ND1   1 
ATOM   4159 C CD2   . HIS   A 1 685  ? 122.661 152.326 134.601 1.00 57.66  ?  685  HIS   C CD2   1 
ATOM   4160 C CE1   . HIS   A 1 685  ? 120.977 153.598 134.004 1.00 56.04  ?  685  HIS   C CE1   1 
ATOM   4161 N NE2   . HIS   A 1 685  ? 121.739 152.590 133.620 1.00 63.42  ?  685  HIS   C NE2   1 
ATOM   4162 N N     . ASN   A 1 686  ? 122.448 156.685 136.450 1.00 46.46  ?  686  ASN   C N     1 
ATOM   4163 C CA    . ASN   A 1 686  ? 121.478 157.774 136.579 1.00 46.99  ?  686  ASN   C CA    1 
ATOM   4164 C C     . ASN   A 1 686  ? 120.039 157.246 136.559 1.00 46.82  ?  686  ASN   C C     1 
ATOM   4165 O O     . ASN   A 1 686  ? 119.746 156.206 135.965 1.00 45.29  ?  686  ASN   C O     1 
ATOM   4166 C CB    . ASN   A 1 686  ? 121.713 158.818 135.474 1.00 50.83  ?  686  ASN   C CB    1 
ATOM   4167 C CG    . ASN   A 1 686  ? 120.909 160.127 135.659 1.00 55.32  ?  686  ASN   C CG    1 
ATOM   4168 O OD1   . ASN   A 1 686  ? 119.712 160.169 135.338 1.00 55.88  ?  686  ASN   C OD1   1 
ATOM   4169 N ND2   . ASN   A 1 686  ? 121.556 161.172 136.169 1.00 42.13  ?  686  ASN   C ND2   1 
ATOM   4170 N N     . LEU   A 1 725  ? 128.249 157.780 134.020 1.00 33.20  ?  725  LEU   C N     1 
ATOM   4171 C CA    . LEU   A 1 725  ? 127.892 158.983 133.276 1.00 43.74  ?  725  LEU   C CA    1 
ATOM   4172 C C     . LEU   A 1 725  ? 127.470 158.659 131.840 1.00 48.09  ?  725  LEU   C C     1 
ATOM   4173 O O     . LEU   A 1 725  ? 126.279 158.706 131.524 1.00 49.32  ?  725  LEU   C O     1 
ATOM   4174 C CB    . LEU   A 1 725  ? 129.069 160.004 133.289 1.00 35.13  ?  725  LEU   C CB    1 
ATOM   4175 C CG    . LEU   A 1 725  ? 129.342 160.753 134.641 1.00 39.95  ?  725  LEU   C CG    1 
ATOM   4176 C CD1   . LEU   A 1 725  ? 130.700 161.489 134.557 1.00 33.03  ?  725  LEU   C CD1   1 
ATOM   4177 C CD2   . LEU   A 1 725  ? 128.193 161.762 134.921 1.00 38.68  ?  725  LEU   C CD2   1 
ATOM   4178 N N     . THR   A 1 726  ? 128.460 158.410 130.954 1.00 45.68  ?  726  THR   C N     1 
ATOM   4179 C CA    . THR   A 1 726  ? 128.292 158.207 129.499 1.00 46.17  ?  726  THR   C CA    1 
ATOM   4180 C C     . THR   A 1 726  ? 127.833 159.487 128.780 1.00 50.66  ?  726  THR   C C     1 
ATOM   4181 O O     . THR   A 1 726  ? 127.744 159.522 127.551 1.00 49.52  ?  726  THR   C O     1 
ATOM   4182 C CB    . THR   A 1 726  ? 127.326 157.047 129.160 1.00 46.25  ?  726  THR   C CB    1 
ATOM   4183 O OG1   . THR   A 1 726  ? 125.971 157.482 129.314 1.00 49.30  ?  726  THR   C OG1   1 
ATOM   4184 C CG2   . THR   A 1 726  ? 127.588 155.834 130.049 1.00 49.77  ?  726  THR   C CG2   1 
ATOM   4185 N N     . SER   A 1 727  ? 127.533 160.525 129.557 1.00 49.14  ?  727  SER   C N     1 
ATOM   4186 C CA    . SER   A 1 727  ? 127.018 161.790 129.051 1.00 51.07  ?  727  SER   C CA    1 
ATOM   4187 C C     . SER   A 1 727  ? 127.659 162.976 129.768 1.00 47.60  ?  727  SER   C C     1 
ATOM   4188 O O     . SER   A 1 727  ? 128.778 162.875 130.269 1.00 41.39  ?  727  SER   C O     1 
ATOM   4189 C CB    . SER   A 1 727  ? 125.512 161.842 129.217 1.00 49.87  ?  727  SER   C CB    1 
ATOM   4190 O OG    . SER   A 1 727  ? 124.968 162.947 128.549 1.00 50.39  ?  727  SER   C OG    1 
ATOM   4191 N N     . SER   A 1 728  ? 126.943 164.098 129.798 1.00 48.61  ?  728  SER   C N     1 
ATOM   4192 C CA    . SER   A 1 728  ? 127.437 165.356 130.354 1.00 44.12  ?  728  SER   C CA    1 
ATOM   4193 C C     . SER   A 1 728  ? 126.688 165.765 131.621 1.00 41.25  ?  728  SER   C C     1 
ATOM   4194 O O     . SER   A 1 728  ? 126.594 166.951 131.940 1.00 36.73  ?  728  SER   C O     1 
ATOM   4195 C CB    . SER   A 1 728  ? 127.314 166.462 129.323 1.00 44.79  ?  728  SER   C CB    1 
ATOM   4196 O OG    . SER   A 1 728  ? 125.981 166.631 128.925 1.00 45.79  ?  728  SER   C OG    1 
ATOM   4197 N N     . PHE   A 1 729  ? 126.167 164.785 132.353 1.00 44.46  ?  729  PHE   C N     1 
ATOM   4198 C CA    . PHE   A 1 729  ? 125.384 165.049 133.562 1.00 43.56  ?  729  PHE   C CA    1 
ATOM   4199 C C     . PHE   A 1 729  ? 126.158 165.910 134.554 1.00 36.74  ?  729  PHE   C C     1 
ATOM   4200 O O     . PHE   A 1 729  ? 125.592 166.765 135.235 1.00 35.81  ?  729  PHE   C O     1 
ATOM   4201 C CB    . PHE   A 1 729  ? 125.028 163.737 134.268 1.00 41.59  ?  729  PHE   C CB    1 
ATOM   4202 C CG    . PHE   A 1 729  ? 124.102 162.825 133.521 1.00 51.27  ?  729  PHE   C CG    1 
ATOM   4203 C CD1   . PHE   A 1 729  ? 124.579 161.642 132.970 1.00 51.89  ?  729  PHE   C CD1   1 
ATOM   4204 C CD2   . PHE   A 1 729  ? 122.758 163.125 133.378 1.00 54.24  ?  729  PHE   C CD2   1 
ATOM   4205 C CE1   . PHE   A 1 729  ? 123.734 160.787 132.292 1.00 55.07  ?  729  PHE   C CE1   1 
ATOM   4206 C CE2   . PHE   A 1 729  ? 121.909 162.267 132.699 1.00 57.12  ?  729  PHE   C CE2   1 
ATOM   4207 C CZ    . PHE   A 1 729  ? 122.400 161.099 132.156 1.00 56.19  ?  729  PHE   C CZ    1 
ATOM   4208 N N     . CYS   A 1 730  ? 127.456 165.656 134.643 1.00 36.62  ?  730  CYS   C N     1 
ATOM   4209 C CA    . CYS   A 1 730  ? 128.344 166.294 135.600 1.00 31.74  ?  730  CYS   C CA    1 
ATOM   4210 C C     . CYS   A 1 730  ? 128.901 167.632 135.128 1.00 28.52  ?  730  CYS   C C     1 
ATOM   4211 O O     . CYS   A 1 730  ? 129.696 168.255 135.830 1.00 26.84  ?  730  CYS   C O     1 
ATOM   4212 C CB    . CYS   A 1 730  ? 129.501 165.358 135.896 1.00 29.22  ?  730  CYS   C CB    1 
ATOM   4213 S SG    . CYS   A 1 730  ? 130.496 165.013 134.449 1.00 38.16  ?  730  CYS   C SG    1 
ATOM   4214 N N     . ARG   A 1 731  ? 128.494 168.089 133.952 1.00 29.98  ?  731  ARG   C N     1 
ATOM   4215 C CA    . ARG   A 1 731  ? 129.015 169.345 133.427 1.00 28.12  ?  731  ARG   C CA    1 
ATOM   4216 C C     . ARG   A 1 731  ? 128.847 170.495 134.414 1.00 27.99  ?  731  ARG   C C     1 
ATOM   4217 O O     . ARG   A 1 731  ? 129.719 171.358 134.523 1.00 27.23  ?  731  ARG   C O     1 
ATOM   4218 C CB    . ARG   A 1 731  ? 128.329 169.710 132.123 1.00 33.20  ?  731  ARG   C CB    1 
ATOM   4219 C CG    . ARG   A 1 731  ? 128.825 170.996 131.492 1.00 32.50  ?  731  ARG   C CG    1 
ATOM   4220 C CD    . ARG   A 1 731  ? 128.170 171.266 130.192 1.00 36.57  ?  731  ARG   C CD    1 
ATOM   4221 N NE    . ARG   A 1 731  ? 128.559 172.563 129.665 1.00 46.89  ?  731  ARG   C NE    1 
ATOM   4222 C CZ    . ARG   A 1 731  ? 129.681 172.806 128.956 1.00 49.29  ?  731  ARG   C CZ    1 
ATOM   4223 N NH1   . ARG   A 1 731  ? 130.518 171.834 128.681 1.00 40.43  1  731  ARG   C NH1   1 
ATOM   4224 N NH2   . ARG   A 1 731  ? 129.942 174.034 128.539 1.00 53.98  ?  731  ARG   C NH2   1 
ATOM   4225 N N     . GLY   A 1 732  ? 127.725 170.510 135.129 1.00 29.00  ?  732  GLY   C N     1 
ATOM   4226 C CA    . GLY   A 1 732  ? 127.426 171.587 136.068 1.00 22.59  ?  732  GLY   C CA    1 
ATOM   4227 C C     . GLY   A 1 732  ? 128.273 171.506 137.333 1.00 24.59  ?  732  GLY   C C     1 
ATOM   4228 O O     . GLY   A 1 732  ? 128.286 172.436 138.137 1.00 24.73  ?  732  GLY   C O     1 
ATOM   4229 N N     . LEU   A 1 733  ? 128.976 170.393 137.512 1.00 24.20  ?  733  LEU   C N     1 
ATOM   4230 C CA    . LEU   A 1 733  ? 129.857 170.228 138.658 1.00 21.53  ?  733  LEU   C CA    1 
ATOM   4231 C C     . LEU   A 1 733  ? 131.295 170.497 138.252 1.00 21.51  ?  733  LEU   C C     1 
ATOM   4232 O O     . LEU   A 1 733  ? 132.050 171.132 138.984 1.00 21.91  ?  733  LEU   C O     1 
ATOM   4233 C CB    . LEU   A 1 733  ? 129.715 168.822 139.247 1.00 23.65  ?  733  LEU   C CB    1 
ATOM   4234 C CG    . LEU   A 1 733  ? 130.647 168.474 140.416 1.00 20.43  ?  733  LEU   C CG    1 
ATOM   4235 C CD1   . LEU   A 1 733  ? 130.456 169.472 141.548 1.00 18.38  ?  733  LEU   C CD1   1 
ATOM   4236 C CD2   . LEU   A 1 733  ? 130.320 167.073 140.892 1.00 19.93  ?  733  LEU   C CD2   1 
ATOM   4237 N N     . PHE   A 1 734  ? 131.669 170.057 137.059 1.00 22.14  ?  734  PHE   C N     1 
ATOM   4238 C CA    . PHE   A 1 734  ? 133.027 170.276 136.582 1.00 19.43  ?  734  PHE   C CA    1 
ATOM   4239 C C     . PHE   A 1 734  ? 133.291 171.766 136.408 1.00 20.96  ?  734  PHE   C C     1 
ATOM   4240 O O     . PHE   A 1 734  ? 134.414 172.233 136.619 1.00 22.78  ?  734  PHE   C O     1 
ATOM   4241 C CB    . PHE   A 1 734  ? 133.268 169.534 135.269 1.00 19.43  ?  734  PHE   C CB    1 
ATOM   4242 C CG    . PHE   A 1 734  ? 133.415 168.028 135.395 1.00 17.74  ?  734  PHE   C CG    1 
ATOM   4243 C CD1   . PHE   A 1 734  ? 133.460 167.381 136.629 1.00 19.02  ?  734  PHE   C CD1   1 
ATOM   4244 C CD2   . PHE   A 1 734  ? 133.530 167.258 134.260 1.00 19.00  ?  734  PHE   C CD2   1 
ATOM   4245 C CE1   . PHE   A 1 734  ? 133.613 166.019 136.704 1.00 19.31  ?  734  PHE   C CE1   1 
ATOM   4246 C CE2   . PHE   A 1 734  ? 133.683 165.899 134.338 1.00 18.34  ?  734  PHE   C CE2   1 
ATOM   4247 C CZ    . PHE   A 1 734  ? 133.726 165.278 135.561 1.00 21.25  ?  734  PHE   C CZ    1 
ATOM   4248 N N     . SER   A 1 735  ? 132.246 172.515 136.062 1.00 21.65  ?  735  SER   C N     1 
ATOM   4249 C CA    . SER   A 1 735  ? 132.341 173.961 135.918 1.00 20.98  ?  735  SER   C CA    1 
ATOM   4250 C C     . SER   A 1 735  ? 132.596 174.638 137.263 1.00 23.08  ?  735  SER   C C     1 
ATOM   4251 O O     . SER   A 1 735  ? 133.012 175.794 137.317 1.00 24.91  ?  735  SER   C O     1 
ATOM   4252 C CB    . SER   A 1 735  ? 131.065 174.501 135.311 1.00 25.27  ?  735  SER   C CB    1 
ATOM   4253 O OG    . SER   A 1 735  ? 130.009 174.433 136.228 1.00 25.62  ?  735  SER   C OG    1 
ATOM   4254 N N     . VAL   A 1 736  ? 132.351 173.910 138.349 1.00 22.82  ?  736  VAL   C N     1 
ATOM   4255 C CA    . VAL   A 1 736  ? 132.600 174.402 139.695 1.00 22.88  ?  736  VAL   C CA    1 
ATOM   4256 C C     . VAL   A 1 736  ? 134.027 174.114 140.097 1.00 23.82  ?  736  VAL   C C     1 
ATOM   4257 O O     . VAL   A 1 736  ? 134.700 174.940 140.713 1.00 24.83  ?  736  VAL   C O     1 
ATOM   4258 C CB    . VAL   A 1 736  ? 131.646 173.744 140.709 1.00 23.70  ?  736  VAL   C CB    1 
ATOM   4259 C CG1   . VAL   A 1 736  ? 132.043 174.121 142.123 1.00 22.78  ?  736  VAL   C CG1   1 
ATOM   4260 C CG2   . VAL   A 1 736  ? 130.229 174.187 140.420 1.00 22.92  ?  736  VAL   C CG2   1 
ATOM   4261 N N     . LEU   A 1 737  ? 134.487 172.927 139.751 1.00 21.89  ?  737  LEU   C N     1 
ATOM   4262 C CA    . LEU   A 1 737  ? 135.814 172.495 140.136 1.00 20.76  ?  737  LEU   C CA    1 
ATOM   4263 C C     . LEU   A 1 737  ? 136.863 173.415 139.535 1.00 23.55  ?  737  LEU   C C     1 
ATOM   4264 O O     . LEU   A 1 737  ? 137.875 173.710 140.167 1.00 24.59  ?  737  LEU   C O     1 
ATOM   4265 C CB    . LEU   A 1 737  ? 136.059 171.073 139.634 1.00 19.03  ?  737  LEU   C CB    1 
ATOM   4266 C CG    . LEU   A 1 737  ? 135.084 170.015 140.135 1.00 20.24  ?  737  LEU   C CG    1 
ATOM   4267 C CD1   . LEU   A 1 737  ? 135.455 168.684 139.520 1.00 18.82  ?  737  LEU   C CD1   1 
ATOM   4268 C CD2   . LEU   A 1 737  ? 135.089 169.969 141.629 1.00 20.16  ?  737  LEU   C CD2   1 
ATOM   4269 N N     . SER   A 1 738  ? 136.603 173.895 138.325 1.00 23.79  ?  738  SER   C N     1 
ATOM   4270 C CA    . SER   A 1 738  ? 137.532 174.758 137.607 1.00 24.21  ?  738  SER   C CA    1 
ATOM   4271 C C     . SER   A 1 738  ? 137.717 176.122 138.252 1.00 25.70  ?  738  SER   C C     1 
ATOM   4272 O O     . SER   A 1 738  ? 138.659 176.839 137.920 1.00 28.86  ?  738  SER   C O     1 
ATOM   4273 C CB    . SER   A 1 738  ? 137.052 174.961 136.194 1.00 26.77  ?  738  SER   C CB    1 
ATOM   4274 O OG    . SER   A 1 738  ? 135.899 175.752 136.164 1.00 28.08  ?  738  SER   C OG    1 
ATOM   4275 N N     . THR   A 1 739  ? 136.827 176.496 139.162 1.00 24.56  ?  739  THR   C N     1 
ATOM   4276 C CA    . THR   A 1 739  ? 136.927 177.797 139.797 1.00 26.37  ?  739  THR   C CA    1 
ATOM   4277 C C     . THR   A 1 739  ? 137.457 177.678 141.219 1.00 26.76  ?  739  THR   C C     1 
ATOM   4278 O O     . THR   A 1 739  ? 137.606 178.682 141.921 1.00 28.05  ?  739  THR   C O     1 
ATOM   4279 C CB    . THR   A 1 739  ? 135.567 178.511 139.798 1.00 30.95  ?  739  THR   C CB    1 
ATOM   4280 O OG1   . THR   A 1 739  ? 134.626 177.764 140.577 1.00 30.28  ?  739  THR   C OG1   1 
ATOM   4281 C CG2   . THR   A 1 739  ? 135.055 178.619 138.374 1.00 32.51  ?  739  THR   C CG2   1 
ATOM   4282 N N     . SER   A 1 740  ? 137.729 176.450 141.650 1.00 25.39  ?  740  SER   C N     1 
ATOM   4283 C CA    . SER   A 1 740  ? 138.260 176.215 142.981 1.00 23.37  ?  740  SER   C CA    1 
ATOM   4284 C C     . SER   A 1 740  ? 139.709 176.635 143.015 1.00 26.03  ?  740  SER   C C     1 
ATOM   4285 O O     . SER   A 1 740  ? 140.454 176.385 142.072 1.00 29.08  ?  740  SER   C O     1 
ATOM   4286 C CB    . SER   A 1 740  ? 138.127 174.757 143.359 1.00 21.87  ?  740  SER   C CB    1 
ATOM   4287 O OG    . SER   A 1 740  ? 138.741 174.496 144.594 1.00 23.53  ?  740  SER   C OG    1 
ATOM   4288 N N     . GLN   A 1 741  ? 140.126 177.281 144.089 1.00 25.35  ?  741  GLN   C N     1 
ATOM   4289 C CA    . GLN   A 1 741  ? 141.507 177.725 144.150 1.00 25.07  ?  741  GLN   C CA    1 
ATOM   4290 C C     . GLN   A 1 741  ? 142.371 176.769 144.951 1.00 23.16  ?  741  GLN   C C     1 
ATOM   4291 O O     . GLN   A 1 741  ? 143.581 176.697 144.740 1.00 27.02  ?  741  GLN   C O     1 
ATOM   4292 C CB    . GLN   A 1 741  ? 141.574 179.130 144.738 1.00 27.63  ?  741  GLN   C CB    1 
ATOM   4293 C CG    . GLN   A 1 741  ? 140.751 180.139 143.959 1.00 31.89  ?  741  GLN   C CG    1 
ATOM   4294 C CD    . GLN   A 1 741  ? 141.173 180.231 142.506 1.00 36.99  ?  741  GLN   C CD    1 
ATOM   4295 O OE1   . GLN   A 1 741  ? 142.328 180.544 142.202 1.00 37.97  ?  741  GLN   C OE1   1 
ATOM   4296 N NE2   . GLN   A 1 741  ? 140.239 179.953 141.599 1.00 34.46  ?  741  GLN   C NE2   1 
ATOM   4297 N N     . SER   A 1 742  ? 141.744 176.036 145.869 1.00 20.71  ?  742  SER   C N     1 
ATOM   4298 C CA    . SER   A 1 742  ? 142.463 175.141 146.765 1.00 19.84  ?  742  SER   C CA    1 
ATOM   4299 C C     . SER   A 1 742  ? 142.583 173.718 146.233 1.00 19.65  ?  742  SER   C C     1 
ATOM   4300 O O     . SER   A 1 742  ? 143.495 172.990 146.620 1.00 20.38  ?  742  SER   C O     1 
ATOM   4301 C CB    . SER   A 1 742  ? 141.774 175.111 148.116 1.00 23.51  ?  742  SER   C CB    1 
ATOM   4302 O OG    . SER   A 1 742  ? 141.805 176.378 148.722 1.00 30.92  ?  742  SER   C OG    1 
ATOM   4303 N N     . LEU   A 1 743  ? 141.668 173.312 145.357 1.00 18.27  ?  743  LEU   C N     1 
ATOM   4304 C CA    . LEU   A 1 743  ? 141.672 171.936 144.871 1.00 14.48  ?  743  LEU   C CA    1 
ATOM   4305 C C     . LEU   A 1 743  ? 142.883 171.656 144.002 1.00 13.98  ?  743  LEU   C C     1 
ATOM   4306 O O     . LEU   A 1 743  ? 143.117 172.355 143.020 1.00 17.65  ?  743  LEU   C O     1 
ATOM   4307 C CB    . LEU   A 1 743  ? 140.402 171.666 144.050 1.00 15.25  ?  743  LEU   C CB    1 
ATOM   4308 C CG    . LEU   A 1 743  ? 140.252 170.248 143.461 1.00 12.39  ?  743  LEU   C CG    1 
ATOM   4309 C CD1   . LEU   A 1 743  ? 140.055 169.250 144.582 1.00 12.47  ?  743  LEU   C CD1   1 
ATOM   4310 C CD2   . LEU   A 1 743  ? 139.073 170.223 142.498 1.00 14.85  ?  743  LEU   C CD2   1 
ATOM   4311 N N     . THR   A 1 744  ? 143.637 170.609 144.335 1.00 13.60  ?  744  THR   C N     1 
ATOM   4312 C CA    . THR   A 1 744  ? 144.791 170.243 143.530 1.00 11.69  ?  744  THR   C CA    1 
ATOM   4313 C C     . THR   A 1 744  ? 144.686 168.831 142.971 1.00 9.58   ?  744  THR   C C     1 
ATOM   4314 O O     . THR   A 1 744  ? 145.232 168.546 141.905 1.00 12.12  ?  744  THR   C O     1 
ATOM   4315 C CB    . THR   A 1 744  ? 146.094 170.359 144.334 1.00 14.62  ?  744  THR   C CB    1 
ATOM   4316 O OG1   . THR   A 1 744  ? 146.047 169.467 145.448 1.00 17.32  ?  744  THR   C OG1   1 
ATOM   4317 C CG2   . THR   A 1 744  ? 146.278 171.778 144.830 1.00 15.59  ?  744  THR   C CG2   1 
ATOM   4318 N N     . GLU   A 1 745  ? 143.984 167.946 143.666 1.00 9.69   ?  745  GLU   C N     1 
ATOM   4319 C CA    . GLU   A 1 745  ? 143.887 166.562 143.214 1.00 8.55   ?  745  GLU   C CA    1 
ATOM   4320 C C     . GLU   A 1 745  ? 142.462 166.151 142.890 1.00 7.74   ?  745  GLU   C C     1 
ATOM   4321 O O     . GLU   A 1 745  ? 141.580 166.205 143.747 1.00 11.75  ?  745  GLU   C O     1 
ATOM   4322 C CB    . GLU   A 1 745  ? 144.463 165.624 144.268 1.00 11.17  ?  745  GLU   C CB    1 
ATOM   4323 C CG    . GLU   A 1 745  ? 144.405 164.154 143.901 1.00 12.53  ?  745  GLU   C CG    1 
ATOM   4324 C CD    . GLU   A 1 745  ? 145.079 163.275 144.910 1.00 17.90  ?  745  GLU   C CD    1 
ATOM   4325 O OE1   . GLU   A 1 745  ? 146.032 163.712 145.514 1.00 20.06  ?  745  GLU   C OE1   1 
ATOM   4326 O OE2   . GLU   A 1 745  ? 144.646 162.162 145.080 1.00 19.68  -1 745  GLU   C OE2   1 
ATOM   4327 N N     . LEU   A 1 746  ? 142.247 165.705 141.660 1.00 7.61   ?  746  LEU   C N     1 
ATOM   4328 C CA    . LEU   A 1 746  ? 140.929 165.266 141.226 1.00 6.37   ?  746  LEU   C CA    1 
ATOM   4329 C C     . LEU   A 1 746  ? 140.935 163.806 140.791 1.00 6.40   ?  746  LEU   C C     1 
ATOM   4330 O O     . LEU   A 1 746  ? 141.630 163.429 139.848 1.00 7.92   ?  746  LEU   C O     1 
ATOM   4331 C CB    . LEU   A 1 746  ? 140.436 166.162 140.086 1.00 7.46   ?  746  LEU   C CB    1 
ATOM   4332 C CG    . LEU   A 1 746  ? 139.109 165.769 139.424 1.00 8.07   ?  746  LEU   C CG    1 
ATOM   4333 C CD1   . LEU   A 1 746  ? 137.975 165.801 140.447 1.00 10.37  ?  746  LEU   C CD1   1 
ATOM   4334 C CD2   . LEU   A 1 746  ? 138.827 166.744 138.298 1.00 11.31  ?  746  LEU   C CD2   1 
ATOM   4335 N N     . ASP   A 1 747  ? 140.151 162.992 141.486 1.00 6.92   ?  747  ASP   C N     1 
ATOM   4336 C CA    . ASP   A 1 747  ? 140.065 161.567 141.204 1.00 5.85   ?  747  ASP   C CA    1 
ATOM   4337 C C     . ASP   A 1 747  ? 138.730 161.190 140.579 1.00 9.08   ?  747  ASP   C C     1 
ATOM   4338 O O     . ASP   A 1 747  ? 137.681 161.266 141.220 1.00 11.62  ?  747  ASP   C O     1 
ATOM   4339 C CB    . ASP   A 1 747  ? 140.307 160.750 142.473 1.00 7.36   ?  747  ASP   C CB    1 
ATOM   4340 C CG    . ASP   A 1 747  ? 140.312 159.241 142.229 1.00 9.26   ?  747  ASP   C CG    1 
ATOM   4341 O OD1   . ASP   A 1 747  ? 139.850 158.814 141.189 1.00 12.93  ?  747  ASP   C OD1   1 
ATOM   4342 O OD2   . ASP   A 1 747  ? 140.785 158.530 143.083 1.00 10.46  -1 747  ASP   C OD2   1 
ATOM   4343 N N     . LEU   A 1 748  ? 138.775 160.829 139.301 1.00 8.16   ?  748  LEU   C N     1 
ATOM   4344 C CA    . LEU   A 1 748  ? 137.582 160.462 138.556 1.00 8.91   ?  748  LEU   C CA    1 
ATOM   4345 C C     . LEU   A 1 748  ? 137.694 159.045 138.033 1.00 10.25  ?  748  LEU   C C     1 
ATOM   4346 O O     . LEU   A 1 748  ? 137.143 158.717 136.986 1.00 14.39  ?  748  LEU   C O     1 
ATOM   4347 C CB    . LEU   A 1 748  ? 137.376 161.419 137.375 1.00 9.62   ?  748  LEU   C CB    1 
ATOM   4348 C CG    . LEU   A 1 748  ? 137.060 162.854 137.729 1.00 10.02  ?  748  LEU   C CG    1 
ATOM   4349 C CD1   . LEU   A 1 748  ? 137.256 163.714 136.518 1.00 10.69  ?  748  LEU   C CD1   1 
ATOM   4350 C CD2   . LEU   A 1 748  ? 135.642 162.950 138.204 1.00 15.31  ?  748  LEU   C CD2   1 
ATOM   4351 N N     . SER   A 1 749  ? 138.413 158.209 138.766 1.00 9.44   ?  749  SER   C N     1 
ATOM   4352 C CA    . SER   A 1 749  ? 138.610 156.822 138.372 1.00 10.24  ?  749  SER   C CA    1 
ATOM   4353 C C     . SER   A 1 749  ? 137.374 155.959 138.595 1.00 17.15  ?  749  SER   C C     1 
ATOM   4354 O O     . SER   A 1 749  ? 136.469 156.317 139.349 1.00 21.92  ?  749  SER   C O     1 
ATOM   4355 C CB    . SER   A 1 749  ? 139.776 156.232 139.137 1.00 9.35   ?  749  SER   C CB    1 
ATOM   4356 O OG    . SER   A 1 749  ? 139.489 156.150 140.504 1.00 13.62  ?  749  SER   C OG    1 
ATOM   4357 N N     . ASP   A 1 750  ? 137.363 154.807 137.939 1.00 14.78  ?  750  ASP   C N     1 
ATOM   4358 C CA    . ASP   A 1 750  ? 136.348 153.777 138.113 1.00 15.58  ?  750  ASP   C CA    1 
ATOM   4359 C C     . ASP   A 1 750  ? 134.909 154.257 137.960 1.00 19.20  ?  750  ASP   C C     1 
ATOM   4360 O O     . ASP   A 1 750  ? 134.026 153.855 138.717 1.00 24.31  ?  750  ASP   C O     1 
ATOM   4361 C CB    . ASP   A 1 750  ? 136.532 153.091 139.460 1.00 18.40  ?  750  ASP   C CB    1 
ATOM   4362 C CG    . ASP   A 1 750  ? 137.878 152.378 139.560 1.00 22.97  ?  750  ASP   C CG    1 
ATOM   4363 O OD1   . ASP   A 1 750  ? 138.605 152.359 138.587 1.00 23.70  ?  750  ASP   C OD1   1 
ATOM   4364 O OD2   . ASP   A 1 750  ? 138.155 151.817 140.593 1.00 26.40  -1 750  ASP   C OD2   1 
ATOM   4365 N N     . ASN   A 1 751  ? 134.665 155.079 136.952 1.00 17.12  ?  751  ASN   C N     1 
ATOM   4366 C CA    . ASN   A 1 751  ? 133.317 155.503 136.606 1.00 19.86  ?  751  ASN   C CA    1 
ATOM   4367 C C     . ASN   A 1 751  ? 133.278 155.769 135.109 1.00 17.22  ?  751  ASN   C C     1 
ATOM   4368 O O     . ASN   A 1 751  ? 134.314 156.028 134.505 1.00 18.50  ?  751  ASN   C O     1 
ATOM   4369 C CB    . ASN   A 1 751  ? 132.904 156.712 137.413 1.00 18.58  ?  751  ASN   C CB    1 
ATOM   4370 C CG    . ASN   A 1 751  ? 133.696 157.895 137.087 1.00 20.40  ?  751  ASN   C CG    1 
ATOM   4371 O OD1   . ASN   A 1 751  ? 133.335 158.668 136.197 1.00 24.40  ?  751  ASN   C OD1   1 
ATOM   4372 N ND2   . ASN   A 1 751  ? 134.775 158.075 137.780 1.00 20.97  ?  751  ASN   C ND2   1 
ATOM   4373 N N     . SER   A 1 752  ? 132.099 155.721 134.503 1.00 20.95  ?  752  SER   C N     1 
ATOM   4374 C CA    . SER   A 1 752  ? 132.003 155.806 133.047 1.00 18.53  ?  752  SER   C CA    1 
ATOM   4375 C C     . SER   A 1 752  ? 132.162 157.213 132.485 1.00 21.10  ?  752  SER   C C     1 
ATOM   4376 O O     . SER   A 1 752  ? 131.283 157.739 131.794 1.00 26.59  ?  752  SER   C O     1 
ATOM   4377 C CB    . SER   A 1 752  ? 130.685 155.226 132.591 1.00 25.34  ?  752  SER   C CB    1 
ATOM   4378 O OG    . SER   A 1 752  ? 130.585 153.873 132.939 1.00 30.17  ?  752  SER   C OG    1 
ATOM   4379 N N     . LEU   A 1 753  ? 133.327 157.794 132.716 1.00 18.08  ?  753  LEU   C N     1 
ATOM   4380 C CA    . LEU   A 1 753  ? 133.661 159.088 132.152 1.00 17.94  ?  753  LEU   C CA    1 
ATOM   4381 C C     . LEU   A 1 753  ? 134.259 158.862 130.783 1.00 18.58  ?  753  LEU   C C     1 
ATOM   4382 O O     . LEU   A 1 753  ? 135.442 159.110 130.561 1.00 20.41  ?  753  LEU   C O     1 
ATOM   4383 C CB    . LEU   A 1 753  ? 134.674 159.816 133.041 1.00 16.51  ?  753  LEU   C CB    1 
ATOM   4384 C CG    . LEU   A 1 753  ? 135.007 161.264 132.665 1.00 15.55  ?  753  LEU   C CG    1 
ATOM   4385 C CD1   . LEU   A 1 753  ? 133.836 162.172 132.995 1.00 23.23  ?  753  LEU   C CD1   1 
ATOM   4386 C CD2   . LEU   A 1 753  ? 136.241 161.681 133.410 1.00 17.00  ?  753  LEU   C CD2   1 
ATOM   4387 N N     . GLY   A 1 754  ? 133.434 158.375 129.872 1.00 17.10  ?  754  GLY   C N     1 
ATOM   4388 C CA    . GLY   A 1 754  ? 133.911 157.988 128.556 1.00 15.59  ?  754  GLY   C CA    1 
ATOM   4389 C C     . GLY   A 1 754  ? 134.217 159.210 127.718 1.00 18.54  ?  754  GLY   C C     1 
ATOM   4390 O O     . GLY   A 1 754  ? 134.077 160.340 128.180 1.00 20.53  ?  754  GLY   C O     1 
ATOM   4391 N N     . ASP   A 1 755  ? 134.632 158.984 126.482 1.00 18.11  ?  755  ASP   C N     1 
ATOM   4392 C CA    . ASP   A 1 755  ? 135.086 160.058 125.612 1.00 19.64  ?  755  ASP   C CA    1 
ATOM   4393 C C     . ASP   A 1 755  ? 134.337 161.401 125.764 1.00 20.87  ?  755  ASP   C C     1 
ATOM   4394 O O     . ASP   A 1 755  ? 134.993 162.406 126.038 1.00 22.58  ?  755  ASP   C O     1 
ATOM   4395 C CB    . ASP   A 1 755  ? 135.089 159.582 124.162 1.00 22.66  ?  755  ASP   C CB    1 
ATOM   4396 C CG    . ASP   A 1 755  ? 136.173 158.520 123.918 1.00 23.40  ?  755  ASP   C CG    1 
ATOM   4397 O OD1   . ASP   A 1 755  ? 136.973 158.288 124.807 1.00 19.78  ?  755  ASP   C OD1   1 
ATOM   4398 O OD2   . ASP   A 1 755  ? 136.184 157.951 122.857 1.00 25.21  -1 755  ASP   C OD2   1 
ATOM   4399 N N     . PRO   A 1 756  ? 132.999 161.487 125.600 1.00 20.32  ?  756  PRO   C N     1 
ATOM   4400 C CA    . PRO   A 1 756  ? 132.238 162.725 125.702 1.00 21.25  ?  756  PRO   C CA    1 
ATOM   4401 C C     . PRO   A 1 756  ? 132.355 163.367 127.083 1.00 20.96  ?  756  PRO   C C     1 
ATOM   4402 O O     . PRO   A 1 756  ? 132.195 164.582 127.222 1.00 21.72  ?  756  PRO   C O     1 
ATOM   4403 C CB    . PRO   A 1 756  ? 130.805 162.261 125.408 1.00 23.56  ?  756  PRO   C CB    1 
ATOM   4404 C CG    . PRO   A 1 756  ? 130.807 160.775 125.665 1.00 21.43  ?  756  PRO   C CG    1 
ATOM   4405 C CD    . PRO   A 1 756  ? 132.175 160.314 125.261 1.00 19.25  ?  756  PRO   C CD    1 
ATOM   4406 N N     . GLY   A 1 757  ? 132.637 162.555 128.098 1.00 20.46  ?  757  GLY   C N     1 
ATOM   4407 C CA    . GLY   A 1 757  ? 132.792 163.054 129.456 1.00 19.67  ?  757  GLY   C CA    1 
ATOM   4408 C C     . GLY   A 1 757  ? 134.148 163.710 129.610 1.00 18.80  ?  757  GLY   C C     1 
ATOM   4409 O O     . GLY   A 1 757  ? 134.303 164.691 130.341 1.00 19.12  ?  757  GLY   C O     1 
ATOM   4410 N N     . MET   A 1 758  ? 135.128 163.168 128.898 1.00 18.81  ?  758  MET   C N     1 
ATOM   4411 C CA    . MET   A 1 758  ? 136.474 163.704 128.941 1.00 16.80  ?  758  MET   C CA    1 
ATOM   4412 C C     . MET   A 1 758  ? 136.531 165.021 128.206 1.00 17.61  ?  758  MET   C C     1 
ATOM   4413 O O     . MET   A 1 758  ? 137.278 165.919 128.588 1.00 18.88  ?  758  MET   C O     1 
ATOM   4414 C CB    . MET   A 1 758  ? 137.470 162.717 128.353 1.00 17.41  ?  758  MET   C CB    1 
ATOM   4415 C CG    . MET   A 1 758  ? 138.918 163.160 128.465 1.00 17.08  ?  758  MET   C CG    1 
ATOM   4416 S SD    . MET   A 1 758  ? 139.373 163.612 130.118 1.00 19.20  ?  758  MET   C SD    1 
ATOM   4417 C CE    . MET   A 1 758  ? 139.021 162.107 130.960 1.00 15.34  ?  758  MET   C CE    1 
ATOM   4418 N N     . ARG   A 1 759  ? 135.725 165.148 127.165 1.00 17.98  ?  759  ARG   C N     1 
ATOM   4419 C CA    . ARG   A 1 759  ? 135.686 166.390 126.419 1.00 18.00  ?  759  ARG   C CA    1 
ATOM   4420 C C     . ARG   A 1 759  ? 135.210 167.519 127.322 1.00 20.03  ?  759  ARG   C C     1 
ATOM   4421 O O     . ARG   A 1 759  ? 135.785 168.608 127.318 1.00 22.28  ?  759  ARG   C O     1 
ATOM   4422 C CB    . ARG   A 1 759  ? 134.778 166.260 125.217 1.00 20.83  ?  759  ARG   C CB    1 
ATOM   4423 C CG    . ARG   A 1 759  ? 134.765 167.460 124.315 1.00 23.28  ?  759  ARG   C CG    1 
ATOM   4424 C CD    . ARG   A 1 759  ? 134.003 167.202 123.077 1.00 18.52  ?  759  ARG   C CD    1 
ATOM   4425 N NE    . ARG   A 1 759  ? 133.973 168.370 122.227 1.00 20.48  ?  759  ARG   C NE    1 
ATOM   4426 C CZ    . ARG   A 1 759  ? 134.964 168.736 121.391 1.00 34.23  ?  759  ARG   C CZ    1 
ATOM   4427 N NH1   . ARG   A 1 759  ? 136.057 168.007 121.299 1.00 40.87  1  759  ARG   C NH1   1 
ATOM   4428 N NH2   . ARG   A 1 759  ? 134.840 169.830 120.663 1.00 42.85  ?  759  ARG   C NH2   1 
ATOM   4429 N N     . VAL   A 1 760  ? 134.184 167.243 128.125 1.00 21.05  ?  760  VAL   C N     1 
ATOM   4430 C CA    . VAL   A 1 760  ? 133.663 168.234 129.061 1.00 20.88  ?  760  VAL   C CA    1 
ATOM   4431 C C     . VAL   A 1 760  ? 134.694 168.576 130.125 1.00 20.21  ?  760  VAL   C C     1 
ATOM   4432 O O     . VAL   A 1 760  ? 134.906 169.744 130.447 1.00 22.39  ?  760  VAL   C O     1 
ATOM   4433 C CB    . VAL   A 1 760  ? 132.393 167.716 129.755 1.00 21.34  ?  760  VAL   C CB    1 
ATOM   4434 C CG1   . VAL   A 1 760  ? 131.961 168.685 130.850 1.00 22.15  ?  760  VAL   C CG1   1 
ATOM   4435 C CG2   . VAL   A 1 760  ? 131.291 167.552 128.736 1.00 29.16  ?  760  VAL   C CG2   1 
ATOM   4436 N N     . LEU   A 1 761  ? 135.337 167.556 130.676 1.00 18.89  ?  761  LEU   C N     1 
ATOM   4437 C CA    . LEU   A 1 761  ? 136.339 167.788 131.699 1.00 16.10  ?  761  LEU   C CA    1 
ATOM   4438 C C     . LEU   A 1 761  ? 137.501 168.600 131.149 1.00 18.97  ?  761  LEU   C C     1 
ATOM   4439 O O     . LEU   A 1 761  ? 137.974 169.534 131.793 1.00 19.12  ?  761  LEU   C O     1 
ATOM   4440 C CB    . LEU   A 1 761  ? 136.858 166.455 132.243 1.00 16.52  ?  761  LEU   C CB    1 
ATOM   4441 C CG    . LEU   A 1 761  ? 137.951 166.540 133.309 1.00 15.53  ?  761  LEU   C CG    1 
ATOM   4442 C CD1   . LEU   A 1 761  ? 137.416 167.242 134.550 1.00 18.68  ?  761  LEU   C CD1   1 
ATOM   4443 C CD2   . LEU   A 1 761  ? 138.423 165.146 133.632 1.00 11.85  ?  761  LEU   C CD2   1 
ATOM   4444 N N     . CYS   A 1 762  ? 137.959 168.248 129.953 1.00 19.14  ?  762  CYS   C N     1 
ATOM   4445 C CA    . CYS   A 1 762  ? 139.083 168.940 129.345 1.00 18.23  ?  762  CYS   C CA    1 
ATOM   4446 C C     . CYS   A 1 762  ? 138.744 170.388 129.058 1.00 21.04  ?  762  CYS   C C     1 
ATOM   4447 O O     . CYS   A 1 762  ? 139.607 171.258 129.137 1.00 21.67  ?  762  CYS   C O     1 
ATOM   4448 C CB    . CYS   A 1 762  ? 139.520 168.240 128.074 1.00 19.63  ?  762  CYS   C CB    1 
ATOM   4449 S SG    . CYS   A 1 762  ? 140.296 166.646 128.383 1.00 21.48  ?  762  CYS   C SG    1 
ATOM   4450 N N     . GLU   A 1 763  ? 137.486 170.658 128.739 1.00 22.92  ?  763  GLU   C N     1 
ATOM   4451 C CA    . GLU   A 1 763  ? 137.050 172.030 128.542 1.00 23.59  ?  763  GLU   C CA    1 
ATOM   4452 C C     . GLU   A 1 763  ? 137.300 172.842 129.806 1.00 22.82  ?  763  GLU   C C     1 
ATOM   4453 O O     . GLU   A 1 763  ? 137.724 173.997 129.741 1.00 23.99  ?  763  GLU   C O     1 
ATOM   4454 C CB    . GLU   A 1 763  ? 135.564 172.075 128.186 1.00 25.20  ?  763  GLU   C CB    1 
ATOM   4455 C CG    . GLU   A 1 763  ? 135.003 173.469 127.923 1.00 35.50  ?  763  GLU   C CG    1 
ATOM   4456 C CD    . GLU   A 1 763  ? 133.532 173.442 127.592 1.00 43.80  ?  763  GLU   C CD    1 
ATOM   4457 O OE1   . GLU   A 1 763  ? 133.016 172.373 127.382 1.00 39.51  ?  763  GLU   C OE1   1 
ATOM   4458 O OE2   . GLU   A 1 763  ? 132.922 174.487 127.558 1.00 42.50  -1 763  GLU   C OE2   1 
ATOM   4459 N N     . THR   A 1 764  ? 137.041 172.230 130.959 1.00 21.59  ?  764  THR   C N     1 
ATOM   4460 C CA    . THR   A 1 764  ? 137.196 172.908 132.238 1.00 20.97  ?  764  THR   C CA    1 
ATOM   4461 C C     . THR   A 1 764  ? 138.644 172.930 132.728 1.00 20.56  ?  764  THR   C C     1 
ATOM   4462 O O     . THR   A 1 764  ? 139.054 173.862 133.422 1.00 22.37  ?  764  THR   C O     1 
ATOM   4463 C CB    . THR   A 1 764  ? 136.284 172.254 133.296 1.00 20.20  ?  764  THR   C CB    1 
ATOM   4464 O OG1   . THR   A 1 764  ? 136.608 170.870 133.435 1.00 21.85  ?  764  THR   C OG1   1 
ATOM   4465 C CG2   . THR   A 1 764  ? 134.827 172.385 132.885 1.00 23.61  ?  764  THR   C CG2   1 
ATOM   4466 N N     . LEU   A 1 765  ? 139.444 171.947 132.321 1.00 20.54  ?  765  LEU   C N     1 
ATOM   4467 C CA    . LEU   A 1 765  ? 140.848 171.884 132.736 1.00 17.86  ?  765  LEU   C CA    1 
ATOM   4468 C C     . LEU   A 1 765  ? 141.693 172.928 132.017 1.00 19.74  ?  765  LEU   C C     1 
ATOM   4469 O O     . LEU   A 1 765  ? 142.858 173.141 132.355 1.00 20.58  ?  765  LEU   C O     1 
ATOM   4470 C CB    . LEU   A 1 765  ? 141.440 170.496 132.462 1.00 17.87  ?  765  LEU   C CB    1 
ATOM   4471 C CG    . LEU   A 1 765  ? 140.887 169.319 133.288 1.00 16.49  ?  765  LEU   C CG    1 
ATOM   4472 C CD1   . LEU   A 1 765  ? 141.431 168.025 132.719 1.00 16.74  ?  765  LEU   C CD1   1 
ATOM   4473 C CD2   . LEU   A 1 765  ? 141.292 169.463 134.740 1.00 14.38  ?  765  LEU   C CD2   1 
ATOM   4474 N N     . GLN   A 1 766  ? 141.105 173.575 131.017 1.00 22.30  ?  766  GLN   C N     1 
ATOM   4475 C CA    . GLN   A 1 766  ? 141.792 174.611 130.260 1.00 22.73  ?  766  GLN   C CA    1 
ATOM   4476 C C     . GLN   A 1 766  ? 141.506 175.994 130.822 1.00 22.60  ?  766  GLN   C C     1 
ATOM   4477 O O     . GLN   A 1 766  ? 141.986 176.995 130.293 1.00 25.64  ?  766  GLN   C O     1 
ATOM   4478 C CB    . GLN   A 1 766  ? 141.410 174.543 128.784 1.00 22.14  ?  766  GLN   C CB    1 
ATOM   4479 C CG    . GLN   A 1 766  ? 141.939 173.311 128.091 1.00 20.81  ?  766  GLN   C CG    1 
ATOM   4480 C CD    . GLN   A 1 766  ? 141.434 173.161 126.687 1.00 21.75  ?  766  GLN   C CD    1 
ATOM   4481 O OE1   . GLN   A 1 766  ? 141.879 173.846 125.762 1.00 27.31  ?  766  GLN   C OE1   1 
ATOM   4482 N NE2   . GLN   A 1 766  ? 140.485 172.256 126.516 1.00 24.38  ?  766  GLN   C NE2   1 
ATOM   4483 N N     . HIS   A 1 767  ? 140.715 176.048 131.888 1.00 24.40  ?  767  HIS   C N     1 
ATOM   4484 C CA    . HIS   A 1 767  ? 140.409 177.304 132.555 1.00 26.59  ?  767  HIS   C CA    1 
ATOM   4485 C C     . HIS   A 1 767  ? 141.678 177.813 133.247 1.00 28.88  ?  767  HIS   C C     1 
ATOM   4486 O O     . HIS   A 1 767  ? 142.354 177.038 133.927 1.00 31.54  ?  767  HIS   C O     1 
ATOM   4487 C CB    . HIS   A 1 767  ? 139.286 177.088 133.577 1.00 29.46  ?  767  HIS   C CB    1 
ATOM   4488 C CG    . HIS   A 1 767  ? 138.703 178.335 134.149 1.00 33.90  ?  767  HIS   C CG    1 
ATOM   4489 N ND1   . HIS   A 1 767  ? 139.363 179.112 135.081 1.00 35.53  ?  767  HIS   C ND1   1 
ATOM   4490 C CD2   . HIS   A 1 767  ? 137.515 178.941 133.925 1.00 32.24  ?  767  HIS   C CD2   1 
ATOM   4491 C CE1   . HIS   A 1 767  ? 138.600 180.144 135.402 1.00 44.08  ?  767  HIS   C CE1   1 
ATOM   4492 N NE2   . HIS   A 1 767  ? 137.476 180.061 134.712 1.00 37.85  ?  767  HIS   C NE2   1 
ATOM   4493 N N     . PRO   A 1 768  ? 142.020 179.100 133.122 1.00 28.85  ?  768  PRO   C N     1 
ATOM   4494 C CA    . PRO   A 1 768  ? 143.232 179.711 133.637 1.00 30.80  ?  768  PRO   C CA    1 
ATOM   4495 C C     . PRO   A 1 768  ? 143.393 179.603 135.152 1.00 30.84  ?  768  PRO   C C     1 
ATOM   4496 O O     . PRO   A 1 768  ? 144.506 179.699 135.663 1.00 35.70  ?  768  PRO   C O     1 
ATOM   4497 C CB    . PRO   A 1 768  ? 143.086 181.173 133.189 1.00 32.85  ?  768  PRO   C CB    1 
ATOM   4498 C CG    . PRO   A 1 768  ? 141.613 181.360 132.917 1.00 32.28  ?  768  PRO   C CG    1 
ATOM   4499 C CD    . PRO   A 1 768  ? 141.141 180.029 132.404 1.00 28.00  ?  768  PRO   C CD    1 
ATOM   4500 N N     . GLY   A 1 769  ? 142.291 179.414 135.876 1.00 31.30  ?  769  GLY   C N     1 
ATOM   4501 C CA    . GLY   A 1 769  ? 142.355 179.327 137.331 1.00 32.91  ?  769  GLY   C CA    1 
ATOM   4502 C C     . GLY   A 1 769  ? 142.151 177.907 137.856 1.00 28.95  ?  769  GLY   C C     1 
ATOM   4503 O O     . GLY   A 1 769  ? 141.902 177.717 139.044 1.00 29.52  ?  769  GLY   C O     1 
ATOM   4504 N N     . CYS   A 1 770  ? 142.228 176.915 136.976 1.00 26.63  ?  770  CYS   C N     1 
ATOM   4505 C CA    . CYS   A 1 770  ? 141.927 175.538 137.357 1.00 24.86  ?  770  CYS   C CA    1 
ATOM   4506 C C     . CYS   A 1 770  ? 142.694 175.053 138.591 1.00 24.50  ?  770  CYS   C C     1 
ATOM   4507 O O     . CYS   A 1 770  ? 142.089 174.576 139.547 1.00 26.03  ?  770  CYS   C O     1 
ATOM   4508 C CB    . CYS   A 1 770  ? 142.217 174.600 136.195 1.00 22.38  ?  770  CYS   C CB    1 
ATOM   4509 S SG    . CYS   A 1 770  ? 141.873 172.891 136.561 1.00 22.36  ?  770  CYS   C SG    1 
ATOM   4510 N N     . ASN   A 1 771  ? 144.018 175.153 138.554 1.00 20.14  ?  771  ASN   C N     1 
ATOM   4511 C CA    . ASN   A 1 771  ? 144.898 174.761 139.662 1.00 19.27  ?  771  ASN   C CA    1 
ATOM   4512 C C     . ASN   A 1 771  ? 144.901 173.274 140.016 1.00 16.51  ?  771  ASN   C C     1 
ATOM   4513 O O     . ASN   A 1 771  ? 145.454 172.890 141.046 1.00 17.13  ?  771  ASN   C O     1 
ATOM   4514 C CB    . ASN   A 1 771  ? 144.597 175.571 140.911 1.00 22.24  ?  771  ASN   C CB    1 
ATOM   4515 C CG    . ASN   A 1 771  ? 144.843 177.031 140.723 1.00 31.14  ?  771  ASN   C CG    1 
ATOM   4516 O OD1   . ASN   A 1 771  ? 145.255 177.469 139.639 1.00 32.29  ?  771  ASN   C OD1   1 
ATOM   4517 N ND2   . ASN   A 1 771  ? 144.618 177.802 141.761 1.00 32.97  ?  771  ASN   C ND2   1 
ATOM   4518 N N     . ILE   A 1 772  ? 144.362 172.425 139.153 1.00 16.09  ?  772  ILE   C N     1 
ATOM   4519 C CA    . ILE   A 1 772  ? 144.463 170.989 139.392 1.00 12.00  ?  772  ILE   C CA    1 
ATOM   4520 C C     . ILE   A 1 772  ? 145.834 170.502 138.966 1.00 10.46  ?  772  ILE   C C     1 
ATOM   4521 O O     . ILE   A 1 772  ? 146.283 170.781 137.856 1.00 14.58  ?  772  ILE   C O     1 
ATOM   4522 C CB    . ILE   A 1 772  ? 143.346 170.201 138.679 1.00 11.96  ?  772  ILE   C CB    1 
ATOM   4523 C CG1   . ILE   A 1 772  ? 141.990 170.597 139.292 1.00 12.89  ?  772  ILE   C CG1   1 
ATOM   4524 C CG2   . ILE   A 1 772  ? 143.585 168.691 138.790 1.00 8.92   ?  772  ILE   C CG2   1 
ATOM   4525 C CD1   . ILE   A 1 772  ? 140.784 170.047 138.564 1.00 15.21  ?  772  ILE   C CD1   1 
ATOM   4526 N N     . ARG   A 1 773  ? 146.512 169.812 139.873 1.00 10.45  ?  773  ARG   C N     1 
ATOM   4527 C CA    . ARG   A 1 773  ? 147.875 169.365 139.655 1.00 9.31   ?  773  ARG   C CA    1 
ATOM   4528 C C     . ARG   A 1 773  ? 147.961 167.861 139.444 1.00 7.64   ?  773  ARG   C C     1 
ATOM   4529 O O     . ARG   A 1 773  ? 148.852 167.375 138.748 1.00 9.62   ?  773  ARG   C O     1 
ATOM   4530 C CB    . ARG   A 1 773  ? 148.733 169.772 140.834 1.00 9.53   ?  773  ARG   C CB    1 
ATOM   4531 C CG    . ARG   A 1 773  ? 148.853 171.270 141.000 1.00 11.30  ?  773  ARG   C CG    1 
ATOM   4532 C CD    . ARG   A 1 773  ? 149.641 171.644 142.184 1.00 16.00  ?  773  ARG   C CD    1 
ATOM   4533 N NE    . ARG   A 1 773  ? 149.620 173.084 142.402 1.00 21.41  ?  773  ARG   C NE    1 
ATOM   4534 C CZ    . ARG   A 1 773  ? 150.460 173.974 141.835 1.00 26.26  ?  773  ARG   C CZ    1 
ATOM   4535 N NH1   . ARG   A 1 773  ? 151.404 173.576 141.010 1.00 25.99  1  773  ARG   C NH1   1 
ATOM   4536 N NH2   . ARG   A 1 773  ? 150.334 175.260 142.111 1.00 26.99  ?  773  ARG   C NH2   1 
ATOM   4537 N N     . ARG   A 1 774  ? 147.040 167.120 140.040 1.00 7.56   ?  774  ARG   C N     1 
ATOM   4538 C CA    . ARG   A 1 774  ? 147.050 165.671 139.905 1.00 5.58   ?  774  ARG   C CA    1 
ATOM   4539 C C     . ARG   A 1 774  ? 145.694 165.174 139.440 1.00 6.19   ?  774  ARG   C C     1 
ATOM   4540 O O     . ARG   A 1 774  ? 144.670 165.484 140.050 1.00 9.20   ?  774  ARG   C O     1 
ATOM   4541 C CB    . ARG   A 1 774  ? 147.424 165.018 141.222 1.00 8.86   ?  774  ARG   C CB    1 
ATOM   4542 C CG    . ARG   A 1 774  ? 148.773 165.449 141.767 1.00 9.75   ?  774  ARG   C CG    1 
ATOM   4543 C CD    . ARG   A 1 774  ? 149.164 164.692 142.979 1.00 11.30  ?  774  ARG   C CD    1 
ATOM   4544 N NE    . ARG   A 1 774  ? 148.342 165.028 144.129 1.00 15.39  ?  774  ARG   C NE    1 
ATOM   4545 C CZ    . ARG   A 1 774  ? 148.534 166.085 144.945 1.00 18.81  ?  774  ARG   C CZ    1 
ATOM   4546 N NH1   . ARG   A 1 774  ? 149.522 166.931 144.745 1.00 18.97  1  774  ARG   C NH1   1 
ATOM   4547 N NH2   . ARG   A 1 774  ? 147.710 166.259 145.958 1.00 21.28  ?  774  ARG   C NH2   1 
ATOM   4548 N N     . LEU   A 1 775  ? 145.684 164.429 138.343 1.00 5.38   ?  775  LEU   C N     1 
ATOM   4549 C CA    . LEU   A 1 775  ? 144.441 163.939 137.769 1.00 5.67   ?  775  LEU   C CA    1 
ATOM   4550 C C     . LEU   A 1 775  ? 144.471 162.428 137.577 1.00 4.80   ?  775  LEU   C C     1 
ATOM   4551 O O     . LEU   A 1 775  ? 145.293 161.899 136.827 1.00 6.19   ?  775  LEU   C O     1 
ATOM   4552 C CB    . LEU   A 1 775  ? 144.197 164.662 136.439 1.00 6.77   ?  775  LEU   C CB    1 
ATOM   4553 C CG    . LEU   A 1 775  ? 142.980 164.250 135.630 1.00 6.79   ?  775  LEU   C CG    1 
ATOM   4554 C CD1   . LEU   A 1 775  ? 141.706 164.516 136.418 1.00 7.45   ?  775  LEU   C CD1   1 
ATOM   4555 C CD2   . LEU   A 1 775  ? 142.974 165.044 134.347 1.00 8.56   ?  775  LEU   C CD2   1 
ATOM   4556 N N     . TRP   A 1 776  ? 143.573 161.737 138.270 1.00 5.24   ?  776  TRP   C N     1 
ATOM   4557 C CA    . TRP   A 1 776  ? 143.535 160.283 138.226 1.00 4.95   ?  776  TRP   C CA    1 
ATOM   4558 C C     . TRP   A 1 776  ? 142.365 159.792 137.386 1.00 5.32   ?  776  TRP   C C     1 
ATOM   4559 O O     . TRP   A 1 776  ? 141.206 160.033 137.724 1.00 7.51   ?  776  TRP   C O     1 
ATOM   4560 C CB    . TRP   A 1 776  ? 143.431 159.716 139.642 1.00 7.01   ?  776  TRP   C CB    1 
ATOM   4561 C CG    . TRP   A 1 776  ? 144.562 160.133 140.516 1.00 7.59   ?  776  TRP   C CG    1 
ATOM   4562 C CD1   . TRP   A 1 776  ? 144.589 161.205 141.346 1.00 8.13   ?  776  TRP   C CD1   1 
ATOM   4563 C CD2   . TRP   A 1 776  ? 145.840 159.491 140.659 1.00 7.60   ?  776  TRP   C CD2   1 
ATOM   4564 N NE1   . TRP   A 1 776  ? 145.793 161.275 141.982 1.00 8.86   ?  776  TRP   C NE1   1 
ATOM   4565 C CE2   . TRP   A 1 776  ? 146.573 160.246 141.567 1.00 3.57   ?  776  TRP   C CE2   1 
ATOM   4566 C CE3   . TRP   A 1 776  ? 146.420 158.361 140.088 1.00 14.31  ?  776  TRP   C CE3   1 
ATOM   4567 C CZ2   . TRP   A 1 776  ? 147.859 159.908 141.928 1.00 14.85  ?  776  TRP   C CZ2   1 
ATOM   4568 C CZ3   . TRP   A 1 776  ? 147.714 158.017 140.447 1.00 11.53  ?  776  TRP   C CZ3   1 
ATOM   4569 C CH2   . TRP   A 1 776  ? 148.418 158.773 141.339 1.00 45.94  ?  776  TRP   C CH2   1 
ATOM   4570 N N     . LEU   A 1 777  ? 142.671 159.115 136.285 1.00 5.54   ?  777  LEU   C N     1 
ATOM   4571 C CA    . LEU   A 1 777  ? 141.657 158.645 135.355 1.00 5.62   ?  777  LEU   C CA    1 
ATOM   4572 C C     . LEU   A 1 777  ? 141.834 157.179 134.999 1.00 6.08   ?  777  LEU   C C     1 
ATOM   4573 O O     . LEU   A 1 777  ? 142.137 156.858 133.851 1.00 8.78   ?  777  LEU   C O     1 
ATOM   4574 C CB    . LEU   A 1 777  ? 141.731 159.463 134.071 1.00 6.86   ?  777  LEU   C CB    1 
ATOM   4575 C CG    . LEU   A 1 777  ? 141.449 160.935 134.195 1.00 5.92   ?  777  LEU   C CG    1 
ATOM   4576 C CD1   . LEU   A 1 777  ? 141.869 161.614 132.922 1.00 7.31   ?  777  LEU   C CD1   1 
ATOM   4577 C CD2   . LEU   A 1 777  ? 139.985 161.137 134.456 1.00 8.12   ?  777  LEU   C CD2   1 
ATOM   4578 N N     . GLY   A 1 778  ? 141.632 156.297 135.971 1.00 7.44   ?  778  GLY   C N     1 
ATOM   4579 C CA    . GLY   A 1 778  ? 141.865 154.868 135.783 1.00 7.77   ?  778  GLY   C CA    1 
ATOM   4580 C C     . GLY   A 1 778  ? 140.806 154.239 134.887 1.00 9.41   ?  778  GLY   C C     1 
ATOM   4581 O O     . GLY   A 1 778  ? 140.681 154.597 133.719 1.00 11.89  ?  778  GLY   C O     1 
ATOM   4582 N N     . ARG   A 1 779  ? 140.031 153.301 135.419 1.00 10.41  ?  779  ARG   C N     1 
ATOM   4583 C CA    . ARG   A 1 779  ? 139.047 152.609 134.590 1.00 9.45   ?  779  ARG   C CA    1 
ATOM   4584 C C     . ARG   A 1 779  ? 137.881 153.519 134.236 1.00 11.03  ?  779  ARG   C C     1 
ATOM   4585 O O     . ARG   A 1 779  ? 136.772 153.340 134.734 1.00 17.35  ?  779  ARG   C O     1 
ATOM   4586 C CB    . ARG   A 1 779  ? 138.500 151.381 135.310 1.00 14.96  ?  779  ARG   C CB    1 
ATOM   4587 C CG    . ARG   A 1 779  ? 139.485 150.257 135.521 1.00 15.58  ?  779  ARG   C CG    1 
ATOM   4588 C CD    . ARG   A 1 779  ? 138.901 149.128 136.301 1.00 18.21  ?  779  ARG   C CD    1 
ATOM   4589 N NE    . ARG   A 1 779  ? 138.639 149.484 137.699 1.00 29.01  ?  779  ARG   C NE    1 
ATOM   4590 C CZ    . ARG   A 1 779  ? 138.104 148.647 138.625 1.00 41.13  ?  779  ARG   C CZ    1 
ATOM   4591 N NH1   . ARG   A 1 779  ? 137.778 147.409 138.297 1.00 37.59  1  779  ARG   C NH1   1 
ATOM   4592 N NH2   . ARG   A 1 779  ? 137.909 149.069 139.864 1.00 37.78  ?  779  ARG   C NH2   1 
ATOM   4593 N N     . CYS   A 1 780  ? 138.139 154.497 133.376 1.00 10.08  ?  780  CYS   C N     1 
ATOM   4594 C CA    . CYS   A 1 780  ? 137.146 155.493 133.006 1.00 8.71   ?  780  CYS   C CA    1 
ATOM   4595 C C     . CYS   A 1 780  ? 136.431 155.180 131.702 1.00 12.30  ?  780  CYS   C C     1 
ATOM   4596 O O     . CYS   A 1 780  ? 135.505 155.887 131.313 1.00 16.03  ?  780  CYS   C O     1 
ATOM   4597 C CB    . CYS   A 1 780  ? 137.795 156.865 132.909 1.00 9.48   ?  780  CYS   C CB    1 
ATOM   4598 S SG    . CYS   A 1 780  ? 138.340 157.513 134.469 1.00 11.69  ?  780  CYS   C SG    1 
ATOM   4599 N N     . GLY   A 1 781  ? 136.854 154.124 131.026 1.00 11.29  ?  781  GLY   C N     1 
ATOM   4600 C CA    . GLY   A 1 781  ? 136.227 153.752 129.769 1.00 8.13   ?  781  GLY   C CA    1 
ATOM   4601 C C     . GLY   A 1 781  ? 136.624 154.689 128.640 1.00 10.99  ?  781  GLY   C C     1 
ATOM   4602 O O     . GLY   A 1 781  ? 135.834 154.938 127.730 1.00 16.14  ?  781  GLY   C O     1 
ATOM   4603 N N     . LEU   A 1 782  ? 137.837 155.218 128.710 1.00 11.55  ?  782  LEU   C N     1 
ATOM   4604 C CA    . LEU   A 1 782  ? 138.322 156.145 127.702 1.00 11.79  ?  782  LEU   C CA    1 
ATOM   4605 C C     . LEU   A 1 782  ? 138.917 155.400 126.524 1.00 12.33  ?  782  LEU   C C     1 
ATOM   4606 O O     . LEU   A 1 782  ? 139.501 154.327 126.692 1.00 11.77  ?  782  LEU   C O     1 
ATOM   4607 C CB    . LEU   A 1 782  ? 139.403 157.045 128.294 1.00 11.91  ?  782  LEU   C CB    1 
ATOM   4608 C CG    . LEU   A 1 782  ? 139.010 157.907 129.476 1.00 10.32  ?  782  LEU   C CG    1 
ATOM   4609 C CD1   . LEU   A 1 782  ? 140.263 158.537 130.061 1.00 11.24  ?  782  LEU   C CD1   1 
ATOM   4610 C CD2   . LEU   A 1 782  ? 138.040 158.978 129.034 1.00 16.14  ?  782  LEU   C CD2   1 
ATOM   4611 N N     . SER   A 1 783  ? 138.819 155.992 125.338 1.00 15.53  ?  783  SER   C N     1 
ATOM   4612 C CA    . SER   A 1 783  ? 139.467 155.430 124.165 1.00 11.74  ?  783  SER   C CA    1 
ATOM   4613 C C     . SER   A 1 783  ? 140.402 156.438 123.528 1.00 13.80  ?  783  SER   C C     1 
ATOM   4614 O O     . SER   A 1 783  ? 140.662 157.501 124.087 1.00 16.57  ?  783  SER   C O     1 
ATOM   4615 C CB    . SER   A 1 783  ? 138.445 154.980 123.153 1.00 15.96  ?  783  SER   C CB    1 
ATOM   4616 O OG    . SER   A 1 783  ? 139.061 154.273 122.113 1.00 17.98  ?  783  SER   C OG    1 
ATOM   4617 N N     . HIS   A 1 784  ? 140.917 156.105 122.357 1.00 13.76  ?  784  HIS   C N     1 
ATOM   4618 C CA    . HIS   A 1 784  ? 141.927 156.929 121.715 1.00 14.12  ?  784  HIS   C CA    1 
ATOM   4619 C C     . HIS   A 1 784  ? 141.464 158.346 121.418 1.00 16.01  ?  784  HIS   C C     1 
ATOM   4620 O O     . HIS   A 1 784  ? 142.269 159.274 121.430 1.00 16.30  ?  784  HIS   C O     1 
ATOM   4621 C CB    . HIS   A 1 784  ? 142.376 156.272 120.415 1.00 14.52  ?  784  HIS   C CB    1 
ATOM   4622 C CG    . HIS   A 1 784  ? 141.263 156.073 119.476 1.00 14.17  ?  784  HIS   C CG    1 
ATOM   4623 N ND1   . HIS   A 1 784  ? 140.413 154.997 119.556 1.00 13.54  ?  784  HIS   C ND1   1 
ATOM   4624 C CD2   . HIS   A 1 784  ? 140.832 156.817 118.441 1.00 16.21  ?  784  HIS   C CD2   1 
ATOM   4625 C CE1   . HIS   A 1 784  ? 139.511 155.084 118.602 1.00 16.05  ?  784  HIS   C CE1   1 
ATOM   4626 N NE2   . HIS   A 1 784  ? 139.744 156.180 117.911 1.00 20.01  ?  784  HIS   C NE2   1 
ATOM   4627 N N     . GLU   A 1 785  ? 140.170 158.542 121.193 1.00 18.03  ?  785  GLU   C N     1 
ATOM   4628 C CA    . GLU   A 1 785  ? 139.686 159.877 120.866 1.00 18.14  ?  785  GLU   C CA    1 
ATOM   4629 C C     . GLU   A 1 785  ? 139.864 160.846 122.023 1.00 17.90  ?  785  GLU   C C     1 
ATOM   4630 O O     . GLU   A 1 785  ? 140.041 162.046 121.815 1.00 19.37  ?  785  GLU   C O     1 
ATOM   4631 C CB    . GLU   A 1 785  ? 138.218 159.851 120.436 1.00 16.96  ?  785  GLU   C CB    1 
ATOM   4632 C CG    . GLU   A 1 785  ? 137.956 159.285 119.032 1.00 24.15  ?  785  GLU   C CG    1 
ATOM   4633 C CD    . GLU   A 1 785  ? 138.576 160.126 117.901 1.00 23.66  ?  785  GLU   C CD    1 
ATOM   4634 O OE1   . GLU   A 1 785  ? 138.979 161.232 118.157 1.00 19.75  ?  785  GLU   C OE1   1 
ATOM   4635 O OE2   . GLU   A 1 785  ? 138.624 159.650 116.791 1.00 16.05  -1 785  GLU   C OE2   1 
ATOM   4636 N N     . CYS   A 1 786  ? 139.830 160.344 123.248 1.00 17.94  ?  786  CYS   C N     1 
ATOM   4637 C CA    . CYS   A 1 786  ? 139.931 161.230 124.392 1.00 15.47  ?  786  CYS   C CA    1 
ATOM   4638 C C     . CYS   A 1 786  ? 141.318 161.841 124.489 1.00 15.28  ?  786  CYS   C C     1 
ATOM   4639 O O     . CYS   A 1 786  ? 141.500 162.865 125.148 1.00 16.16  ?  786  CYS   C O     1 
ATOM   4640 C CB    . CYS   A 1 786  ? 139.682 160.487 125.686 1.00 16.61  ?  786  CYS   C CB    1 
ATOM   4641 S SG    . CYS   A 1 786  ? 141.106 159.570 126.245 1.00 19.24  ?  786  CYS   C SG    1 
ATOM   4642 N N     . CYS   A 1 787  ? 142.303 161.203 123.857 1.00 15.49  ?  787  CYS   C N     1 
ATOM   4643 C CA    . CYS   A 1 787  ? 143.673 161.677 123.944 1.00 11.16  ?  787  CYS   C CA    1 
ATOM   4644 C C     . CYS   A 1 787  ? 143.846 162.956 123.168 1.00 11.29  ?  787  CYS   C C     1 
ATOM   4645 O O     . CYS   A 1 787  ? 144.789 163.710 123.400 1.00 12.58  ?  787  CYS   C O     1 
ATOM   4646 C CB    . CYS   A 1 787  ? 144.652 160.641 123.424 1.00 11.62  ?  787  CYS   C CB    1 
ATOM   4647 S SG    . CYS   A 1 787  ? 144.813 159.205 124.483 1.00 15.19  ?  787  CYS   C SG    1 
ATOM   4648 N N     . PHE   A 1 788  ? 142.928 163.222 122.252 1.00 11.94  ?  788  PHE   C N     1 
ATOM   4649 C CA    . PHE   A 1 788  ? 142.991 164.457 121.506 1.00 10.10  ?  788  PHE   C CA    1 
ATOM   4650 C C     . PHE   A 1 788  ? 142.773 165.616 122.461 1.00 13.25  ?  788  PHE   C C     1 
ATOM   4651 O O     . PHE   A 1 788  ? 143.478 166.624 122.408 1.00 15.16  ?  788  PHE   C O     1 
ATOM   4652 C CB    . PHE   A 1 788  ? 141.951 164.486 120.395 1.00 11.81  ?  788  PHE   C CB    1 
ATOM   4653 C CG    . PHE   A 1 788  ? 142.019 165.731 119.603 1.00 10.04  ?  788  PHE   C CG    1 
ATOM   4654 C CD1   . PHE   A 1 788  ? 143.067 165.950 118.745 1.00 7.93   ?  788  PHE   C CD1   1 
ATOM   4655 C CD2   . PHE   A 1 788  ? 141.047 166.694 119.722 1.00 13.25  ?  788  PHE   C CD2   1 
ATOM   4656 C CE1   . PHE   A 1 788  ? 143.148 167.107 118.024 1.00 4.47   ?  788  PHE   C CE1   1 
ATOM   4657 C CE2   . PHE   A 1 788  ? 141.124 167.854 118.999 1.00 11.27  ?  788  PHE   C CE2   1 
ATOM   4658 C CZ    . PHE   A 1 788  ? 142.179 168.060 118.151 1.00 5.40   ?  788  PHE   C CZ    1 
ATOM   4659 N N     . ASP   A 1 789  ? 141.791 165.463 123.343 1.00 14.36  ?  789  ASP   C N     1 
ATOM   4660 C CA    . ASP   A 1 789  ? 141.431 166.515 124.274 1.00 14.17  ?  789  ASP   C CA    1 
ATOM   4661 C C     . ASP   A 1 789  ? 142.432 166.596 125.415 1.00 14.59  ?  789  ASP   C C     1 
ATOM   4662 O O     . ASP   A 1 789  ? 142.734 167.684 125.905 1.00 17.40  ?  789  ASP   C O     1 
ATOM   4663 C CB    . ASP   A 1 789  ? 140.034 166.258 124.818 1.00 17.75  ?  789  ASP   C CB    1 
ATOM   4664 C CG    . ASP   A 1 789  ? 138.961 166.340 123.750 1.00 22.97  ?  789  ASP   C CG    1 
ATOM   4665 O OD1   . ASP   A 1 789  ? 139.011 167.228 122.929 1.00 23.95  ?  789  ASP   C OD1   1 
ATOM   4666 O OD2   . ASP   A 1 789  ? 138.096 165.502 123.760 1.00 21.85  -1 789  ASP   C OD2   1 
ATOM   4667 N N     . ILE   A 1 790  ? 142.974 165.452 125.818 1.00 13.60  ?  790  ILE   C N     1 
ATOM   4668 C CA    . ILE   A 1 790  ? 143.981 165.442 126.871 1.00 11.36  ?  790  ILE   C CA    1 
ATOM   4669 C C     . ILE   A 1 790  ? 145.217 166.182 126.396 1.00 13.22  ?  790  ILE   C C     1 
ATOM   4670 O O     . ILE   A 1 790  ? 145.825 166.937 127.154 1.00 14.77  ?  790  ILE   C O     1 
ATOM   4671 C CB    . ILE   A 1 790  ? 144.340 164.016 127.308 1.00 11.35  ?  790  ILE   C CB    1 
ATOM   4672 C CG1   . ILE   A 1 790  ? 143.137 163.385 128.013 1.00 12.98  ?  790  ILE   C CG1   1 
ATOM   4673 C CG2   . ILE   A 1 790  ? 145.554 164.045 128.236 1.00 11.33  ?  790  ILE   C CG2   1 
ATOM   4674 C CD1   . ILE   A 1 790  ? 143.247 161.891 128.205 1.00 13.65  ?  790  ILE   C CD1   1 
ATOM   4675 N N     . SER   A 1 791  ? 145.595 165.961 125.140 1.00 13.07  ?  791  SER   C N     1 
ATOM   4676 C CA    . SER   A 1 791  ? 146.735 166.649 124.560 1.00 12.11  ?  791  SER   C CA    1 
ATOM   4677 C C     . SER   A 1 791  ? 146.544 168.156 124.604 1.00 14.59  ?  791  SER   C C     1 
ATOM   4678 O O     . SER   A 1 791  ? 147.454 168.894 124.987 1.00 16.34  ?  791  SER   C O     1 
ATOM   4679 C CB    . SER   A 1 791  ? 146.937 166.208 123.131 1.00 14.11  ?  791  SER   C CB    1 
ATOM   4680 O OG    . SER   A 1 791  ? 147.996 166.903 122.541 1.00 17.49  ?  791  SER   C OG    1 
ATOM   4681 N N     . LEU   A 1 792  ? 145.347 168.617 124.249 1.00 15.98  ?  792  LEU   C N     1 
ATOM   4682 C CA    . LEU   A 1 792  ? 145.063 170.045 124.270 1.00 15.39  ?  792  LEU   C CA    1 
ATOM   4683 C C     . LEU   A 1 792  ? 145.226 170.613 125.672 1.00 15.68  ?  792  LEU   C C     1 
ATOM   4684 O O     . LEU   A 1 792  ? 145.708 171.734 125.841 1.00 17.84  ?  792  LEU   C O     1 
ATOM   4685 C CB    . LEU   A 1 792  ? 143.639 170.310 123.776 1.00 18.32  ?  792  LEU   C CB    1 
ATOM   4686 C CG    . LEU   A 1 792  ? 143.368 170.031 122.287 1.00 15.85  ?  792  LEU   C CG    1 
ATOM   4687 C CD1   . LEU   A 1 792  ? 141.875 170.116 122.035 1.00 15.27  ?  792  LEU   C CD1   1 
ATOM   4688 C CD2   . LEU   A 1 792  ? 144.108 171.041 121.426 1.00 19.06  ?  792  LEU   C CD2   1 
ATOM   4689 N N     . VAL   A 1 793  ? 144.845 169.838 126.682 1.00 15.54  ?  793  VAL   C N     1 
ATOM   4690 C CA    . VAL   A 1 793  ? 145.018 170.281 128.057 1.00 14.03  ?  793  VAL   C CA    1 
ATOM   4691 C C     . VAL   A 1 793  ? 146.497 170.382 128.399 1.00 14.78  ?  793  VAL   C C     1 
ATOM   4692 O O     . VAL   A 1 793  ? 146.942 171.377 128.967 1.00 17.39  ?  793  VAL   C O     1 
ATOM   4693 C CB    . VAL   A 1 793  ? 144.326 169.319 129.041 1.00 14.18  ?  793  VAL   C CB    1 
ATOM   4694 C CG1   . VAL   A 1 793  ? 144.684 169.683 130.480 1.00 15.62  ?  793  VAL   C CG1   1 
ATOM   4695 C CG2   . VAL   A 1 793  ? 142.827 169.392 128.844 1.00 15.32  ?  793  VAL   C CG2   1 
ATOM   4696 N N     . LEU   A 1 794  ? 147.271 169.368 128.026 1.00 14.64  ?  794  LEU   C N     1 
ATOM   4697 C CA    . LEU   A 1 794  ? 148.701 169.348 128.328 1.00 13.84  ?  794  LEU   C CA    1 
ATOM   4698 C C     . LEU   A 1 794  ? 149.436 170.520 127.692 1.00 15.36  ?  794  LEU   C C     1 
ATOM   4699 O O     . LEU   A 1 794  ? 150.364 171.077 128.279 1.00 18.90  ?  794  LEU   C O     1 
ATOM   4700 C CB    . LEU   A 1 794  ? 149.324 168.038 127.831 1.00 12.70  ?  794  LEU   C CB    1 
ATOM   4701 C CG    . LEU   A 1 794  ? 148.926 166.756 128.577 1.00 8.87   ?  794  LEU   C CG    1 
ATOM   4702 C CD1   . LEU   A 1 794  ? 149.427 165.555 127.796 1.00 9.52   ?  794  LEU   C CD1   1 
ATOM   4703 C CD2   . LEU   A 1 794  ? 149.528 166.761 129.967 1.00 10.16  ?  794  LEU   C CD2   1 
ATOM   4704 N N     . SER   A 1 795  ? 148.998 170.921 126.508 1.00 16.53  ?  795  SER   C N     1 
ATOM   4705 C CA    . SER   A 1 795  ? 149.632 172.010 125.777 1.00 16.81  ?  795  SER   C CA    1 
ATOM   4706 C C     . SER   A 1 795  ? 149.261 173.402 126.299 1.00 18.98  ?  795  SER   C C     1 
ATOM   4707 O O     . SER   A 1 795  ? 149.800 174.403 125.826 1.00 21.76  ?  795  SER   C O     1 
ATOM   4708 C CB    . SER   A 1 795  ? 149.275 171.917 124.308 1.00 17.14  ?  795  SER   C CB    1 
ATOM   4709 O OG    . SER   A 1 795  ? 149.804 170.755 123.730 1.00 19.89  ?  795  SER   C OG    1 
ATOM   4710 N N     . SER   A 1 796  ? 148.326 173.476 127.245 1.00 20.19  ?  796  SER   C N     1 
ATOM   4711 C CA    . SER   A 1 796  ? 147.873 174.764 127.770 1.00 19.64  ?  796  SER   C CA    1 
ATOM   4712 C C     . SER   A 1 796  ? 148.035 174.873 129.284 1.00 22.63  ?  796  SER   C C     1 
ATOM   4713 O O     . SER   A 1 796  ? 148.523 175.880 129.801 1.00 23.38  ?  796  SER   C O     1 
ATOM   4714 C CB    . SER   A 1 796  ? 146.425 175.003 127.405 1.00 23.45  ?  796  SER   C CB    1 
ATOM   4715 O OG    . SER   A 1 796  ? 145.985 176.231 127.925 1.00 29.22  ?  796  SER   C OG    1 
ATOM   4716 N N     . ASN   A 1 797  ? 147.589 173.846 129.997 1.00 22.74  ?  797  ASN   C N     1 
ATOM   4717 C CA    . ASN   A 1 797  ? 147.613 173.838 131.451 1.00 19.87  ?  797  ASN   C CA    1 
ATOM   4718 C C     . ASN   A 1 797  ? 149.009 173.522 131.958 1.00 19.43  ?  797  ASN   C C     1 
ATOM   4719 O O     . ASN   A 1 797  ? 149.483 172.393 131.851 1.00 19.61  ?  797  ASN   C O     1 
ATOM   4720 C CB    . ASN   A 1 797  ? 146.607 172.837 131.982 1.00 17.58  ?  797  ASN   C CB    1 
ATOM   4721 C CG    . ASN   A 1 797  ? 146.538 172.808 133.469 1.00 21.35  ?  797  ASN   C CG    1 
ATOM   4722 O OD1   . ASN   A 1 797  ? 147.568 172.870 134.156 1.00 22.92  ?  797  ASN   C OD1   1 
ATOM   4723 N ND2   . ASN   A 1 797  ? 145.342 172.719 133.997 1.00 22.35  ?  797  ASN   C ND2   1 
ATOM   4724 N N     . GLN   A 1 798  ? 149.668 174.531 132.512 1.00 20.89  ?  798  GLN   C N     1 
ATOM   4725 C CA    . GLN   A 1 798  ? 151.053 174.404 132.944 1.00 23.23  ?  798  GLN   C CA    1 
ATOM   4726 C C     . GLN   A 1 798  ? 151.179 173.953 134.393 1.00 22.59  ?  798  GLN   C C     1 
ATOM   4727 O O     . GLN   A 1 798  ? 152.285 173.891 134.933 1.00 25.30  ?  798  GLN   C O     1 
ATOM   4728 C CB    . GLN   A 1 798  ? 151.795 175.729 132.753 1.00 24.65  ?  798  GLN   C CB    1 
ATOM   4729 C CG    . GLN   A 1 798  ? 151.941 176.158 131.305 1.00 28.69  ?  798  GLN   C CG    1 
ATOM   4730 C CD    . GLN   A 1 798  ? 152.725 177.449 131.161 1.00 36.74  ?  798  GLN   C CD    1 
ATOM   4731 O OE1   . GLN   A 1 798  ? 153.900 177.519 131.533 1.00 35.08  ?  798  GLN   C OE1   1 
ATOM   4732 N NE2   . GLN   A 1 798  ? 152.084 178.479 130.623 1.00 38.22  ?  798  GLN   C NE2   1 
ATOM   4733 N N     . LYS   A 1 799  ? 150.050 173.668 135.036 1.00 19.07  ?  799  LYS   C N     1 
ATOM   4734 C CA    . LYS   A 1 799  ? 150.076 173.254 136.432 1.00 16.21  ?  799  LYS   C CA    1 
ATOM   4735 C C     . LYS   A 1 799  ? 149.928 171.749 136.588 1.00 14.23  ?  799  LYS   C C     1 
ATOM   4736 O O     . LYS   A 1 799  ? 150.392 171.180 137.570 1.00 14.55  ?  799  LYS   C O     1 
ATOM   4737 C CB    . LYS   A 1 799  ? 149.000 173.974 137.237 1.00 19.16  ?  799  LYS   C CB    1 
ATOM   4738 C CG    . LYS   A 1 799  ? 149.256 175.465 137.418 1.00 25.14  ?  799  LYS   C CG    1 
ATOM   4739 C CD    . LYS   A 1 799  ? 148.236 176.094 138.348 1.00 24.20  ?  799  LYS   C CD    1 
ATOM   4740 C CE    . LYS   A 1 799  ? 148.588 177.536 138.696 1.00 30.92  ?  799  LYS   C CE    1 
ATOM   4741 N NZ    . LYS   A 1 799  ? 148.340 178.460 137.559 1.00 40.28  1  799  LYS   C NZ    1 
ATOM   4742 N N     . LEU   A 1 800  ? 149.305 171.092 135.620 1.00 12.81  ?  800  LEU   C N     1 
ATOM   4743 C CA    . LEU   A 1 800  ? 149.114 169.652 135.731 1.00 10.28  ?  800  LEU   C CA    1 
ATOM   4744 C C     . LEU   A 1 800  ? 150.463 168.936 135.775 1.00 9.39   ?  800  LEU   C C     1 
ATOM   4745 O O     . LEU   A 1 800  ? 151.301 169.117 134.894 1.00 11.78  ?  800  LEU   C O     1 
ATOM   4746 C CB    . LEU   A 1 800  ? 148.265 169.141 134.556 1.00 9.39   ?  800  LEU   C CB    1 
ATOM   4747 C CG    . LEU   A 1 800  ? 147.930 167.629 134.546 1.00 8.73   ?  800  LEU   C CG    1 
ATOM   4748 C CD1   . LEU   A 1 800  ? 147.047 167.281 135.736 1.00 9.48   ?  800  LEU   C CD1   1 
ATOM   4749 C CD2   . LEU   A 1 800  ? 147.219 167.286 133.246 1.00 10.29  ?  800  LEU   C CD2   1 
ATOM   4750 N N     . VAL   A 1 801  ? 150.666 168.131 136.819 1.00 9.51   ?  801  VAL   C N     1 
ATOM   4751 C CA    . VAL   A 1 801  ? 151.916 167.413 137.045 1.00 6.36   ?  801  VAL   C CA    1 
ATOM   4752 C C     . VAL   A 1 801  ? 151.775 165.903 136.907 1.00 5.81   ?  801  VAL   C C     1 
ATOM   4753 O O     . VAL   A 1 801  ? 152.655 165.246 136.352 1.00 7.69   ?  801  VAL   C O     1 
ATOM   4754 C CB    . VAL   A 1 801  ? 152.478 167.729 138.441 1.00 6.41   ?  801  VAL   C CB    1 
ATOM   4755 C CG1   . VAL   A 1 801  ? 153.699 166.887 138.709 1.00 11.45  ?  801  VAL   C CG1   1 
ATOM   4756 C CG2   . VAL   A 1 801  ? 152.847 169.184 138.514 1.00 9.96   ?  801  VAL   C CG2   1 
ATOM   4757 N N     . GLU   A 1 802  ? 150.711 165.341 137.465 1.00 6.70   ?  802  GLU   C N     1 
ATOM   4758 C CA    . GLU   A 1 802  ? 150.558 163.891 137.467 1.00 4.62   ?  802  GLU   C CA    1 
ATOM   4759 C C     . GLU   A 1 802  ? 149.311 163.469 136.712 1.00 4.96   ?  802  GLU   C C     1 
ATOM   4760 O O     . GLU   A 1 802  ? 148.219 163.963 136.988 1.00 8.24   ?  802  GLU   C O     1 
ATOM   4761 C CB    . GLU   A 1 802  ? 150.473 163.362 138.897 1.00 7.00   ?  802  GLU   C CB    1 
ATOM   4762 C CG    . GLU   A 1 802  ? 151.644 163.732 139.790 1.00 9.37   ?  802  GLU   C CG    1 
ATOM   4763 C CD    . GLU   A 1 802  ? 151.572 163.067 141.147 1.00 15.59  ?  802  GLU   C CD    1 
ATOM   4764 O OE1   . GLU   A 1 802  ? 150.697 162.262 141.339 1.00 17.23  ?  802  GLU   C OE1   1 
ATOM   4765 O OE2   . GLU   A 1 802  ? 152.390 163.367 141.991 1.00 16.46  -1 802  GLU   C OE2   1 
ATOM   4766 N N     . LEU   A 1 803  ? 149.469 162.549 135.769 1.00 4.32   ?  803  LEU   C N     1 
ATOM   4767 C CA    . LEU   A 1 803  ? 148.335 162.069 134.990 1.00 4.07   ?  803  LEU   C CA    1 
ATOM   4768 C C     . LEU   A 1 803  ? 148.302 160.549 134.912 1.00 3.82   ?  803  LEU   C C     1 
ATOM   4769 O O     . LEU   A 1 803  ? 149.216 159.925 134.372 1.00 5.64   ?  803  LEU   C O     1 
ATOM   4770 C CB    . LEU   A 1 803  ? 148.400 162.666 133.581 1.00 6.58   ?  803  LEU   C CB    1 
ATOM   4771 C CG    . LEU   A 1 803  ? 147.344 162.213 132.581 1.00 2.35   ?  803  LEU   C CG    1 
ATOM   4772 C CD1   . LEU   A 1 803  ? 145.964 162.646 133.044 1.00 6.56   ?  803  LEU   C CD1   1 
ATOM   4773 C CD2   . LEU   A 1 803  ? 147.670 162.812 131.229 1.00 4.88   ?  803  LEU   C CD2   1 
ATOM   4774 N N     . ASP   A 1 804  ? 147.235 159.958 135.433 1.00 4.89   ?  804  ASP   C N     1 
ATOM   4775 C CA    . ASP   A 1 804  ? 147.087 158.508 135.420 1.00 4.37   ?  804  ASP   C CA    1 
ATOM   4776 C C     . ASP   A 1 804  ? 146.006 158.050 134.461 1.00 4.84   ?  804  ASP   C C     1 
ATOM   4777 O O     . ASP   A 1 804  ? 144.824 158.298 134.688 1.00 7.15   ?  804  ASP   C O     1 
ATOM   4778 C CB    . ASP   A 1 804  ? 146.786 157.975 136.814 1.00 5.04   ?  804  ASP   C CB    1 
ATOM   4779 C CG    . ASP   A 1 804  ? 146.703 156.457 136.862 1.00 5.83   ?  804  ASP   C CG    1 
ATOM   4780 O OD1   . ASP   A 1 804  ? 146.757 155.849 135.817 1.00 8.03   ?  804  ASP   C OD1   1 
ATOM   4781 O OD2   . ASP   A 1 804  ? 146.575 155.917 137.929 1.00 8.71   -1 804  ASP   C OD2   1 
ATOM   4782 N N     . LEU   A 1 805  ? 146.413 157.411 133.371 1.00 5.30   ?  805  LEU   C N     1 
ATOM   4783 C CA    . LEU   A 1 805  ? 145.488 156.951 132.346 1.00 4.77   ?  805  LEU   C CA    1 
ATOM   4784 C C     . LEU   A 1 805  ? 145.440 155.436 132.275 1.00 5.35   ?  805  LEU   C C     1 
ATOM   4785 O O     . LEU   A 1 805  ? 145.116 154.871 131.232 1.00 8.47   ?  805  LEU   C O     1 
ATOM   4786 C CB    . LEU   A 1 805  ? 145.894 157.511 130.983 1.00 5.88   ?  805  LEU   C CB    1 
ATOM   4787 C CG    . LEU   A 1 805  ? 145.862 159.027 130.850 1.00 5.35   ?  805  LEU   C CG    1 
ATOM   4788 C CD1   . LEU   A 1 805  ? 146.500 159.434 129.542 1.00 6.06   ?  805  LEU   C CD1   1 
ATOM   4789 C CD2   . LEU   A 1 805  ? 144.431 159.513 130.911 1.00 6.71   ?  805  LEU   C CD2   1 
ATOM   4790 N N     . SER   A 1 806  ? 145.764 154.780 133.377 1.00 6.29   ?  806  SER   C N     1 
ATOM   4791 C CA    . SER   A 1 806  ? 145.809 153.327 133.423 1.00 5.71   ?  806  SER   C CA    1 
ATOM   4792 C C     . SER   A 1 806  ? 144.452 152.699 133.166 1.00 8.04   ?  806  SER   C C     1 
ATOM   4793 O O     . SER   A 1 806  ? 143.416 153.293 133.442 1.00 11.62  ?  806  SER   C O     1 
ATOM   4794 C CB    . SER   A 1 806  ? 146.292 152.858 134.779 1.00 6.21   ?  806  SER   C CB    1 
ATOM   4795 O OG    . SER   A 1 806  ? 147.563 153.354 135.065 1.00 6.30   ?  806  SER   C OG    1 
ATOM   4796 N N     . ASP   A 1 807  ? 144.469 151.471 132.672 1.00 8.08   ?  807  ASP   C N     1 
ATOM   4797 C CA    . ASP   A 1 807  ? 143.268 150.666 132.478 1.00 8.37   ?  807  ASP   C CA    1 
ATOM   4798 C C     . ASP   A 1 807  ? 142.227 151.300 131.561 1.00 9.67   ?  807  ASP   C C     1 
ATOM   4799 O O     . ASP   A 1 807  ? 141.025 151.210 131.814 1.00 12.25  ?  807  ASP   C O     1 
ATOM   4800 C CB    . ASP   A 1 807  ? 142.623 150.358 133.824 1.00 12.18  ?  807  ASP   C CB    1 
ATOM   4801 C CG    . ASP   A 1 807  ? 143.508 149.531 134.739 1.00 17.06  ?  807  ASP   C CG    1 
ATOM   4802 O OD1   . ASP   A 1 807  ? 144.043 148.545 134.290 1.00 16.88  ?  807  ASP   C OD1   1 
ATOM   4803 O OD2   . ASP   A 1 807  ? 143.636 149.887 135.887 1.00 21.01  -1 807  ASP   C OD2   1 
ATOM   4804 N N     . ASN   A 1 808  ? 142.687 151.893 130.472 1.00 9.18   ?  808  ASN   C N     1 
ATOM   4805 C CA    . ASN   A 1 808  ? 141.813 152.434 129.443 1.00 8.08   ?  808  ASN   C CA    1 
ATOM   4806 C C     . ASN   A 1 808  ? 142.136 151.760 128.117 1.00 9.25   ?  808  ASN   C C     1 
ATOM   4807 O O     . ASN   A 1 808  ? 143.014 150.905 128.052 1.00 11.22  ?  808  ASN   C O     1 
ATOM   4808 C CB    . ASN   A 1 808  ? 141.959 153.935 129.355 1.00 9.19   ?  808  ASN   C CB    1 
ATOM   4809 C CG    . ASN   A 1 808  ? 141.366 154.642 130.525 1.00 9.25   ?  808  ASN   C CG    1 
ATOM   4810 O OD1   . ASN   A 1 808  ? 140.134 154.779 130.655 1.00 10.67  ?  808  ASN   C OD1   1 
ATOM   4811 N ND2   . ASN   A 1 808  ? 142.226 155.099 131.388 1.00 9.40   ?  808  ASN   C ND2   1 
ATOM   4812 N N     . ALA   A 1 809  ? 141.438 152.137 127.056 1.00 11.04  ?  809  ALA   C N     1 
ATOM   4813 C CA    . ALA   A 1 809  ? 141.673 151.539 125.747 1.00 6.98   ?  809  ALA   C CA    1 
ATOM   4814 C C     . ALA   A 1 809  ? 142.458 152.489 124.869 1.00 8.62   ?  809  ALA   C C     1 
ATOM   4815 O O     . ALA   A 1 809  ? 142.203 152.616 123.672 1.00 12.31  ?  809  ALA   C O     1 
ATOM   4816 C CB    . ALA   A 1 809  ? 140.360 151.178 125.085 1.00 11.74  ?  809  ALA   C CB    1 
ATOM   4817 N N     . LEU   A 1 810  ? 143.420 153.161 125.464 1.00 8.82   ?  810  LEU   C N     1 
ATOM   4818 C CA    . LEU   A 1 810  ? 144.198 154.148 124.742 1.00 8.89   ?  810  LEU   C CA    1 
ATOM   4819 C C     . LEU   A 1 810  ? 145.292 153.449 123.974 1.00 11.26  ?  810  LEU   C C     1 
ATOM   4820 O O     . LEU   A 1 810  ? 146.434 153.411 124.418 1.00 15.32  ?  810  LEU   C O     1 
ATOM   4821 C CB    . LEU   A 1 810  ? 144.833 155.138 125.716 1.00 7.89   ?  810  LEU   C CB    1 
ATOM   4822 C CG    . LEU   A 1 810  ? 143.886 155.769 126.718 1.00 12.01  ?  810  LEU   C CG    1 
ATOM   4823 C CD1   . LEU   A 1 810  ? 144.647 156.768 127.551 1.00 13.53  ?  810  LEU   C CD1   1 
ATOM   4824 C CD2   . LEU   A 1 810  ? 142.718 156.398 126.008 1.00 16.76  ?  810  LEU   C CD2   1 
ATOM   4825 N N     . GLY   A 1 811  ? 144.939 152.870 122.838 1.00 8.87   ?  811  GLY   C N     1 
ATOM   4826 C CA    . GLY   A 1 811  ? 145.875 152.030 122.106 1.00 8.94   ?  811  GLY   C CA    1 
ATOM   4827 C C     . GLY   A 1 811  ? 146.975 152.849 121.453 1.00 10.19  ?  811  GLY   C C     1 
ATOM   4828 O O     . GLY   A 1 811  ? 147.118 154.045 121.713 1.00 12.79  ?  811  GLY   C O     1 
ATOM   4829 N N     . ASP   A 1 812  ? 147.745 152.210 120.583 1.00 9.66   ?  812  ASP   C N     1 
ATOM   4830 C CA    . ASP   A 1 812  ? 148.904 152.850 119.977 1.00 11.35  ?  812  ASP   C CA    1 
ATOM   4831 C C     . ASP   A 1 812  ? 148.565 154.189 119.343 1.00 11.71  ?  812  ASP   C C     1 
ATOM   4832 O O     . ASP   A 1 812  ? 149.364 155.125 119.388 1.00 13.09  ?  812  ASP   C O     1 
ATOM   4833 C CB    . ASP   A 1 812  ? 149.506 151.940 118.918 1.00 14.74  ?  812  ASP   C CB    1 
ATOM   4834 C CG    . ASP   A 1 812  ? 150.137 150.704 119.501 1.00 17.78  ?  812  ASP   C CG    1 
ATOM   4835 O OD1   . ASP   A 1 812  ? 150.358 150.661 120.694 1.00 16.00  ?  812  ASP   C OD1   1 
ATOM   4836 O OD2   . ASP   A 1 812  ? 150.361 149.794 118.757 1.00 20.86  -1 812  ASP   C OD2   1 
ATOM   4837 N N     . PHE   A 1 813  ? 147.386 154.289 118.749 1.00 10.52  ?  813  PHE   C N     1 
ATOM   4838 C CA    . PHE   A 1 813  ? 146.984 155.539 118.132 1.00 8.72   ?  813  PHE   C CA    1 
ATOM   4839 C C     . PHE   A 1 813  ? 146.750 156.617 119.180 1.00 10.70  ?  813  PHE   C C     1 
ATOM   4840 O O     . PHE   A 1 813  ? 147.132 157.772 118.988 1.00 11.61  ?  813  PHE   C O     1 
ATOM   4841 C CB    . PHE   A 1 813  ? 145.745 155.348 117.272 1.00 10.38  ?  813  PHE   C CB    1 
ATOM   4842 C CG    . PHE   A 1 813  ? 145.304 156.602 116.614 1.00 11.02  ?  813  PHE   C CG    1 
ATOM   4843 C CD1   . PHE   A 1 813  ? 146.172 157.336 115.829 1.00 8.95   ?  813  PHE   C CD1   1 
ATOM   4844 C CD2   . PHE   A 1 813  ? 144.021 157.049 116.771 1.00 10.15  ?  813  PHE   C CD2   1 
ATOM   4845 C CE1   . PHE   A 1 813  ? 145.761 158.491 115.233 1.00 4.52   ?  813  PHE   C CE1   1 
ATOM   4846 C CE2   . PHE   A 1 813  ? 143.607 158.201 116.170 1.00 6.42   ?  813  PHE   C CE2   1 
ATOM   4847 C CZ    . PHE   A 1 813  ? 144.477 158.923 115.402 1.00 3.33   ?  813  PHE   C CZ    1 
ATOM   4848 N N     . GLY   A 1 814  ? 146.111 156.249 120.284 1.00 11.48  ?  814  GLY   C N     1 
ATOM   4849 C CA    . GLY   A 1 814  ? 145.829 157.209 121.341 1.00 10.60  ?  814  GLY   C CA    1 
ATOM   4850 C C     . GLY   A 1 814  ? 147.120 157.799 121.882 1.00 10.26  ?  814  GLY   C C     1 
ATOM   4851 O O     . GLY   A 1 814  ? 147.207 159.001 122.135 1.00 11.45  ?  814  GLY   C O     1 
ATOM   4852 N N     . ILE   A 1 815  ? 148.140 156.962 122.019 1.00 10.80  ?  815  ILE   C N     1 
ATOM   4853 C CA    . ILE   A 1 815  ? 149.425 157.436 122.508 1.00 10.28  ?  815  ILE   C CA    1 
ATOM   4854 C C     . ILE   A 1 815  ? 150.060 158.375 121.507 1.00 11.22  ?  815  ILE   C C     1 
ATOM   4855 O O     . ILE   A 1 815  ? 150.583 159.424 121.880 1.00 12.76  ?  815  ILE   C O     1 
ATOM   4856 C CB    . ILE   A 1 815  ? 150.381 156.279 122.816 1.00 10.08  ?  815  ILE   C CB    1 
ATOM   4857 C CG1   . ILE   A 1 815  ? 149.802 155.401 123.926 1.00 11.50  ?  815  ILE   C CG1   1 
ATOM   4858 C CG2   . ILE   A 1 815  ? 151.759 156.799 123.197 1.00 11.33  ?  815  ILE   C CG2   1 
ATOM   4859 C CD1   . ILE   A 1 815  ? 149.429 156.115 125.215 1.00 9.92   ?  815  ILE   C CD1   1 
ATOM   4860 N N     . ARG   A 1 816  ? 149.982 158.034 120.231 1.00 12.31  ?  816  ARG   C N     1 
ATOM   4861 C CA    . ARG   A 1 816  ? 150.520 158.912 119.210 1.00 11.86  ?  816  ARG   C CA    1 
ATOM   4862 C C     . ARG   A 1 816  ? 149.924 160.310 119.335 1.00 10.56  ?  816  ARG   C C     1 
ATOM   4863 O O     . ARG   A 1 816  ? 150.635 161.305 119.198 1.00 12.81  ?  816  ARG   C O     1 
ATOM   4864 C CB    . ARG   A 1 816  ? 150.240 158.361 117.830 1.00 11.66  ?  816  ARG   C CB    1 
ATOM   4865 C CG    . ARG   A 1 816  ? 150.848 159.151 116.709 1.00 12.31  ?  816  ARG   C CG    1 
ATOM   4866 C CD    . ARG   A 1 816  ? 150.590 158.518 115.412 1.00 14.65  ?  816  ARG   C CD    1 
ATOM   4867 N NE    . ARG   A 1 816  ? 151.218 159.240 114.334 1.00 9.81   ?  816  ARG   C NE    1 
ATOM   4868 C CZ    . ARG   A 1 816  ? 151.077 158.942 113.037 1.00 3.46   ?  816  ARG   C CZ    1 
ATOM   4869 N NH1   . ARG   A 1 816  ? 150.320 157.935 112.674 1.00 5.34   1  816  ARG   C NH1   1 
ATOM   4870 N NH2   . ARG   A 1 816  ? 151.701 159.662 112.126 1.00 15.44  ?  816  ARG   C NH2   1 
ATOM   4871 N N     . LEU   A 1 817  ? 148.619 160.382 119.604 1.00 11.47  ?  817  LEU   C N     1 
ATOM   4872 C CA    . LEU   A 1 817  ? 147.953 161.667 119.805 1.00 9.88   ?  817  LEU   C CA    1 
ATOM   4873 C C     . LEU   A 1 817  ? 148.375 162.319 121.115 1.00 11.41  ?  817  LEU   C C     1 
ATOM   4874 O O     . LEU   A 1 817  ? 148.628 163.520 121.173 1.00 13.54  ?  817  LEU   C O     1 
ATOM   4875 C CB    . LEU   A 1 817  ? 146.430 161.486 119.845 1.00 9.78   ?  817  LEU   C CB    1 
ATOM   4876 C CG    . LEU   A 1 817  ? 145.735 161.081 118.553 1.00 7.86   ?  817  LEU   C CG    1 
ATOM   4877 C CD1   . LEU   A 1 817  ? 144.293 160.720 118.875 1.00 8.73   ?  817  LEU   C CD1   1 
ATOM   4878 C CD2   . LEU   A 1 817  ? 145.787 162.223 117.560 1.00 9.99   ?  817  LEU   C CD2   1 
ATOM   4879 N N     . LEU   A 1 818  ? 148.473 161.523 122.169 1.00 11.17  ?  818  LEU   C N     1 
ATOM   4880 C CA    . LEU   A 1 818  ? 148.826 162.039 123.483 1.00 9.36   ?  818  LEU   C CA    1 
ATOM   4881 C C     . LEU   A 1 818  ? 150.204 162.670 123.461 1.00 10.77  ?  818  LEU   C C     1 
ATOM   4882 O O     . LEU   A 1 818  ? 150.437 163.716 124.074 1.00 11.90  ?  818  LEU   C O     1 
ATOM   4883 C CB    . LEU   A 1 818  ? 148.805 160.900 124.510 1.00 9.96   ?  818  LEU   C CB    1 
ATOM   4884 C CG    . LEU   A 1 818  ? 149.061 161.273 125.976 1.00 9.51   ?  818  LEU   C CG    1 
ATOM   4885 C CD1   . LEU   A 1 818  ? 147.956 162.193 126.476 1.00 10.84  ?  818  LEU   C CD1   1 
ATOM   4886 C CD2   . LEU   A 1 818  ? 149.125 159.997 126.806 1.00 8.22   ?  818  LEU   C CD2   1 
ATOM   4887 N N     . CYS   A 1 819  ? 151.114 162.037 122.733 1.00 11.60  ?  819  CYS   C N     1 
ATOM   4888 C CA    . CYS   A 1 819  ? 152.497 162.472 122.661 1.00 11.62  ?  819  CYS   C CA    1 
ATOM   4889 C C     . CYS   A 1 819  ? 152.651 163.830 122.009 1.00 13.58  ?  819  CYS   C C     1 
ATOM   4890 O O     . CYS   A 1 819  ? 153.695 164.468 122.141 1.00 15.71  ?  819  CYS   C O     1 
ATOM   4891 C CB    . CYS   A 1 819  ? 153.340 161.449 121.917 1.00 12.54  ?  819  CYS   C CB    1 
ATOM   4892 S SG    . CYS   A 1 819  ? 153.529 159.899 122.812 1.00 17.53  ?  819  CYS   C SG    1 
ATOM   4893 N N     . VAL   A 1 820  ? 151.619 164.291 121.320 1.00 13.39  ?  820  VAL   C N     1 
ATOM   4894 C CA    . VAL   A 1 820  ? 151.681 165.600 120.707 1.00 11.80  ?  820  VAL   C CA    1 
ATOM   4895 C C     . VAL   A 1 820  ? 151.751 166.653 121.796 1.00 14.47  ?  820  VAL   C C     1 
ATOM   4896 O O     . VAL   A 1 820  ? 152.454 167.654 121.662 1.00 16.74  ?  820  VAL   C O     1 
ATOM   4897 C CB    . VAL   A 1 820  ? 150.468 165.845 119.801 1.00 12.00  ?  820  VAL   C CB    1 
ATOM   4898 C CG1   . VAL   A 1 820  ? 150.465 167.282 119.309 1.00 11.56  ?  820  VAL   C CG1   1 
ATOM   4899 C CG2   . VAL   A 1 820  ? 150.520 164.880 118.636 1.00 12.59  ?  820  VAL   C CG2   1 
ATOM   4900 N N     . GLY   A 1 821  ? 150.995 166.434 122.869 1.00 14.53  ?  821  GLY   C N     1 
ATOM   4901 C CA    . GLY   A 1 821  ? 150.985 167.357 123.991 1.00 12.82  ?  821  GLY   C CA    1 
ATOM   4902 C C     . GLY   A 1 821  ? 152.228 167.169 124.843 1.00 13.33  ?  821  GLY   C C     1 
ATOM   4903 O O     . GLY   A 1 821  ? 152.822 168.133 125.315 1.00 16.47  ?  821  GLY   C O     1 
ATOM   4904 N N     . LEU   A 1 822  ? 152.642 165.922 125.020 1.00 12.22  ?  822  LEU   C N     1 
ATOM   4905 C CA    . LEU   A 1 822  ? 153.780 165.625 125.881 1.00 11.25  ?  822  LEU   C CA    1 
ATOM   4906 C C     . LEU   A 1 822  ? 155.060 166.253 125.346 1.00 14.22  ?  822  LEU   C C     1 
ATOM   4907 O O     . LEU   A 1 822  ? 155.921 166.673 126.117 1.00 16.70  ?  822  LEU   C O     1 
ATOM   4908 C CB    . LEU   A 1 822  ? 153.960 164.112 126.024 1.00 11.41  ?  822  LEU   C CB    1 
ATOM   4909 C CG    . LEU   A 1 822  ? 152.832 163.363 126.772 1.00 9.33   ?  822  LEU   C CG    1 
ATOM   4910 C CD1   . LEU   A 1 822  ? 153.029 161.865 126.629 1.00 11.67  ?  822  LEU   C CD1   1 
ATOM   4911 C CD2   . LEU   A 1 822  ? 152.850 163.743 128.234 1.00 9.01   ?  822  LEU   C CD2   1 
ATOM   4912 N N     . LYS   A 1 823  ? 155.177 166.345 124.026 1.00 15.47  ?  823  LYS   C N     1 
ATOM   4913 C CA    . LYS   A 1 823  ? 156.355 166.943 123.404 1.00 15.76  ?  823  LYS   C CA    1 
ATOM   4914 C C     . LYS   A 1 823  ? 156.250 168.460 123.285 1.00 17.04  ?  823  LYS   C C     1 
ATOM   4915 O O     . LYS   A 1 823  ? 157.166 169.108 122.777 1.00 19.15  ?  823  LYS   C O     1 
ATOM   4916 C CB    . LYS   A 1 823  ? 156.578 166.365 122.008 1.00 16.52  ?  823  LYS   C CB    1 
ATOM   4917 C CG    . LYS   A 1 823  ? 156.950 164.902 121.971 1.00 19.72  ?  823  LYS   C CG    1 
ATOM   4918 C CD    . LYS   A 1 823  ? 157.310 164.456 120.556 1.00 22.31  ?  823  LYS   C CD    1 
ATOM   4919 C CE    . LYS   A 1 823  ? 156.073 164.364 119.662 1.00 23.86  ?  823  LYS   C CE    1 
ATOM   4920 N NZ    . LYS   A 1 823  ? 156.385 163.748 118.347 1.00 28.84  1  823  LYS   C NZ    1 
ATOM   4921 N N     . HIS   A 1 824  ? 155.121 169.021 123.700 1.00 17.68  ?  824  HIS   C N     1 
ATOM   4922 C CA    . HIS   A 1 824  ? 154.875 170.446 123.550 1.00 19.33  ?  824  HIS   C CA    1 
ATOM   4923 C C     . HIS   A 1 824  ? 155.621 171.266 124.588 1.00 20.46  ?  824  HIS   C C     1 
ATOM   4924 O O     . HIS   A 1 824  ? 155.682 170.908 125.766 1.00 21.58  ?  824  HIS   C O     1 
ATOM   4925 C CB    . HIS   A 1 824  ? 153.377 170.748 123.641 1.00 20.49  ?  824  HIS   C CB    1 
ATOM   4926 C CG    . HIS   A 1 824  ? 153.018 172.153 123.270 1.00 22.00  ?  824  HIS   C CG    1 
ATOM   4927 N ND1   . HIS   A 1 824  ? 153.096 172.624 121.978 1.00 28.89  ?  824  HIS   C ND1   1 
ATOM   4928 C CD2   . HIS   A 1 824  ? 152.577 173.186 124.019 1.00 22.79  ?  824  HIS   C CD2   1 
ATOM   4929 C CE1   . HIS   A 1 824  ? 152.716 173.888 121.952 1.00 29.39  ?  824  HIS   C CE1   1 
ATOM   4930 N NE2   . HIS   A 1 824  ? 152.396 174.251 123.177 1.00 23.57  ?  824  HIS   C NE2   1 
ATOM   4931 N N     . LEU   A 1 825  ? 156.163 172.391 124.156 1.00 25.68  ?  825  LEU   C N     1 
ATOM   4932 C CA    . LEU   A 1 825  ? 156.832 173.290 125.074 1.00 26.01  ?  825  LEU   C CA    1 
ATOM   4933 C C     . LEU   A 1 825  ? 155.841 173.774 126.114 1.00 26.15  ?  825  LEU   C C     1 
ATOM   4934 O O     . LEU   A 1 825  ? 154.686 174.041 125.801 1.00 27.79  ?  825  LEU   C O     1 
ATOM   4935 C CB    . LEU   A 1 825  ? 157.431 174.482 124.325 1.00 30.33  ?  825  LEU   C CB    1 
ATOM   4936 C CG    . LEU   A 1 825  ? 158.326 175.436 125.150 1.00 36.81  ?  825  LEU   C CG    1 
ATOM   4937 C CD1   . LEU   A 1 825  ? 159.619 174.725 125.548 1.00 37.13  ?  825  LEU   C CD1   1 
ATOM   4938 C CD2   . LEU   A 1 825  ? 158.617 176.667 124.320 1.00 34.83  ?  825  LEU   C CD2   1 
ATOM   4939 N N     . LEU   A 1 826  ? 156.304 173.877 127.349 1.00 26.64  ?  826  LEU   C N     1 
ATOM   4940 C CA    . LEU   A 1 826  ? 155.504 174.301 128.495 1.00 28.07  ?  826  LEU   C CA    1 
ATOM   4941 C C     . LEU   A 1 826  ? 154.616 173.183 129.033 1.00 25.01  ?  826  LEU   C C     1 
ATOM   4942 O O     . LEU   A 1 826  ? 153.841 173.400 129.964 1.00 28.26  ?  826  LEU   C O     1 
ATOM   4943 C CB    . LEU   A 1 826  ? 154.608 175.503 128.140 1.00 33.03  ?  826  LEU   C CB    1 
ATOM   4944 C CG    . LEU   A 1 826  ? 155.289 176.701 127.442 1.00 37.30  ?  826  LEU   C CG    1 
ATOM   4945 C CD1   . LEU   A 1 826  ? 154.247 177.766 127.165 1.00 35.14  ?  826  LEU   C CD1   1 
ATOM   4946 C CD2   . LEU   A 1 826  ? 156.400 177.240 128.320 1.00 36.41  ?  826  LEU   C CD2   1 
ATOM   4947 N N     . CYS   A 1 827  ? 154.775 171.968 128.520 1.00 22.20  ?  827  CYS   C N     1 
ATOM   4948 C CA    . CYS   A 1 827  ? 154.092 170.839 129.134 1.00 18.41  ?  827  CYS   C CA    1 
ATOM   4949 C C     . CYS   A 1 827  ? 154.935 170.354 130.295 1.00 19.37  ?  827  CYS   C C     1 
ATOM   4950 O O     . CYS   A 1 827  ? 156.057 169.895 130.105 1.00 21.92  ?  827  CYS   C O     1 
ATOM   4951 C CB    . CYS   A 1 827  ? 153.892 169.701 128.144 1.00 17.81  ?  827  CYS   C CB    1 
ATOM   4952 S SG    . CYS   A 1 827  ? 153.130 168.238 128.869 1.00 17.18  ?  827  CYS   C SG    1 
ATOM   4953 N N     . ASN   A 1 828  ? 154.413 170.491 131.505 1.00 16.51  ?  828  ASN   C N     1 
ATOM   4954 C CA    . ASN   A 1 828  ? 155.207 170.235 132.698 1.00 15.87  ?  828  ASN   C CA    1 
ATOM   4955 C C     . ASN   A 1 828  ? 154.865 168.924 133.381 1.00 12.28  ?  828  ASN   C C     1 
ATOM   4956 O O     . ASN   A 1 828  ? 155.184 168.729 134.553 1.00 13.02  ?  828  ASN   C O     1 
ATOM   4957 C CB    . ASN   A 1 828  ? 155.063 171.385 133.667 1.00 16.43  ?  828  ASN   C CB    1 
ATOM   4958 C CG    . ASN   A 1 828  ? 155.632 172.674 133.126 1.00 21.86  ?  828  ASN   C CG    1 
ATOM   4959 O OD1   . ASN   A 1 828  ? 156.664 172.700 132.433 1.00 24.51  ?  828  ASN   C OD1   1 
ATOM   4960 N ND2   . ASN   A 1 828  ? 154.971 173.761 133.436 1.00 27.40  ?  828  ASN   C ND2   1 
ATOM   4961 N N     . LEU   A 1 829  ? 154.217 168.022 132.667 1.00 10.67  ?  829  LEU   C N     1 
ATOM   4962 C CA    . LEU   A 1 829  ? 153.837 166.754 133.256 1.00 8.01   ?  829  LEU   C CA    1 
ATOM   4963 C C     . LEU   A 1 829  ? 155.073 166.011 133.740 1.00 8.46   ?  829  LEU   C C     1 
ATOM   4964 O O     . LEU   A 1 829  ? 156.064 165.918 133.013 1.00 12.52  ?  829  LEU   C O     1 
ATOM   4965 C CB    . LEU   A 1 829  ? 153.087 165.901 132.229 1.00 7.58   ?  829  LEU   C CB    1 
ATOM   4966 C CG    . LEU   A 1 829  ? 152.313 164.705 132.777 1.00 4.72   ?  829  LEU   C CG    1 
ATOM   4967 C CD1   . LEU   A 1 829  ? 151.075 165.204 133.505 1.00 6.79   ?  829  LEU   C CD1   1 
ATOM   4968 C CD2   . LEU   A 1 829  ? 151.938 163.778 131.647 1.00 5.48   ?  829  LEU   C CD2   1 
ATOM   4969 N N     . LYS   A 1 830  ? 155.032 165.486 134.962 1.00 8.59   ?  830  LYS   C N     1 
ATOM   4970 C CA    . LYS   A 1 830  ? 156.170 164.769 135.521 1.00 7.39   ?  830  LYS   C CA    1 
ATOM   4971 C C     . LYS   A 1 830  ? 155.935 163.271 135.646 1.00 6.18   ?  830  LYS   C C     1 
ATOM   4972 O O     . LYS   A 1 830  ? 156.867 162.481 135.501 1.00 8.39   ?  830  LYS   C O     1 
ATOM   4973 C CB    . LYS   A 1 830  ? 156.548 165.319 136.888 1.00 8.55   ?  830  LYS   C CB    1 
ATOM   4974 C CG    . LYS   A 1 830  ? 157.052 166.746 136.870 1.00 9.92   ?  830  LYS   C CG    1 
ATOM   4975 C CD    . LYS   A 1 830  ? 157.452 167.213 138.254 1.00 15.49  ?  830  LYS   C CD    1 
ATOM   4976 C CE    . LYS   A 1 830  ? 157.903 168.658 138.232 1.00 22.31  ?  830  LYS   C CE    1 
ATOM   4977 N NZ    . LYS   A 1 830  ? 158.284 169.136 139.582 1.00 23.56  1  830  LYS   C NZ    1 
ATOM   4978 N N     . LYS   A 1 831  ? 154.697 162.880 135.937 1.00 6.54   ?  831  LYS   C N     1 
ATOM   4979 C CA    . LYS   A 1 831  ? 154.409 161.466 136.153 1.00 3.71   ?  831  LYS   C CA    1 
ATOM   4980 C C     . LYS   A 1 831  ? 153.289 160.996 135.248 1.00 3.57   ?  831  LYS   C C     1 
ATOM   4981 O O     . LYS   A 1 831  ? 152.206 161.573 135.245 1.00 5.52   ?  831  LYS   C O     1 
ATOM   4982 C CB    . LYS   A 1 831  ? 154.006 161.222 137.603 1.00 5.94   ?  831  LYS   C CB    1 
ATOM   4983 C CG    . LYS   A 1 831  ? 154.992 161.724 138.633 1.00 8.10   ?  831  LYS   C CG    1 
ATOM   4984 C CD    . LYS   A 1 831  ? 154.577 161.313 140.019 1.00 10.47  ?  831  LYS   C CD    1 
ATOM   4985 C CE    . LYS   A 1 831  ? 155.443 161.973 141.068 1.00 15.05  ?  831  LYS   C CE    1 
ATOM   4986 N NZ    . LYS   A 1 831  ? 154.833 161.881 142.413 1.00 22.10  1  831  LYS   C NZ    1 
ATOM   4987 N N     . LEU   A 1 832  ? 153.548 159.937 134.492 1.00 3.61   ?  832  LEU   C N     1 
ATOM   4988 C CA    . LEU   A 1 832  ? 152.541 159.418 133.579 1.00 3.17   ?  832  LEU   C CA    1 
ATOM   4989 C C     . LEU   A 1 832  ? 152.363 157.908 133.695 1.00 3.77   ?  832  LEU   C C     1 
ATOM   4990 O O     . LEU   A 1 832  ? 153.311 157.145 133.520 1.00 6.05   ?  832  LEU   C O     1 
ATOM   4991 C CB    . LEU   A 1 832  ? 152.936 159.787 132.144 1.00 5.81   ?  832  LEU   C CB    1 
ATOM   4992 C CG    . LEU   A 1 832  ? 152.043 159.262 131.019 1.00 5.12   ?  832  LEU   C CG    1 
ATOM   4993 C CD1   . LEU   A 1 832  ? 150.653 159.886 131.103 1.00 4.32   ?  832  LEU   C CD1   1 
ATOM   4994 C CD2   . LEU   A 1 832  ? 152.696 159.588 129.696 1.00 6.53   ?  832  LEU   C CD2   1 
ATOM   4995 N N     . TRP   A 1 833  ? 151.129 157.486 133.964 1.00 4.69   ?  833  TRP   C N     1 
ATOM   4996 C CA    . TRP   A 1 833  ? 150.815 156.061 134.038 1.00 4.61   ?  833  TRP   C CA    1 
ATOM   4997 C C     . TRP   A 1 833  ? 150.022 155.610 132.823 1.00 4.85   ?  833  TRP   C C     1 
ATOM   4998 O O     . TRP   A 1 833  ? 148.913 156.086 132.585 1.00 6.63   ?  833  TRP   C O     1 
ATOM   4999 C CB    . TRP   A 1 833  ? 149.985 155.722 135.278 1.00 5.18   ?  833  TRP   C CB    1 
ATOM   5000 C CG    . TRP   A 1 833  ? 150.676 155.808 136.586 1.00 5.27   ?  833  TRP   C CG    1 
ATOM   5001 C CD1   . TRP   A 1 833  ? 151.169 154.768 137.303 1.00 5.39   ?  833  TRP   C CD1   1 
ATOM   5002 C CD2   . TRP   A 1 833  ? 150.941 156.986 137.362 1.00 4.78   ?  833  TRP   C CD2   1 
ATOM   5003 N NE1   . TRP   A 1 833  ? 151.719 155.217 138.465 1.00 5.63   ?  833  TRP   C NE1   1 
ATOM   5004 C CE2   . TRP   A 1 833  ? 151.590 156.572 138.518 1.00 5.19   ?  833  TRP   C CE2   1 
ATOM   5005 C CE3   . TRP   A 1 833  ? 150.679 158.337 137.175 1.00 4.62   ?  833  TRP   C CE3   1 
ATOM   5006 C CZ2   . TRP   A 1 833  ? 151.988 157.462 139.486 1.00 7.54   ?  833  TRP   C CZ2   1 
ATOM   5007 C CZ3   . TRP   A 1 833  ? 151.075 159.230 138.145 1.00 5.43   ?  833  TRP   C CZ3   1 
ATOM   5008 C CH2   . TRP   A 1 833  ? 151.713 158.806 139.272 1.00 7.72   ?  833  TRP   C CH2   1 
ATOM   5009 N N     . LEU   A 1 834  ? 150.584 154.674 132.069 1.00 5.35   ?  834  LEU   C N     1 
ATOM   5010 C CA    . LEU   A 1 834  ? 149.930 154.121 130.890 1.00 5.21   ?  834  LEU   C CA    1 
ATOM   5011 C C     . LEU   A 1 834  ? 149.793 152.617 131.023 1.00 5.36   ?  834  LEU   C C     1 
ATOM   5012 O O     . LEU   A 1 834  ? 149.892 151.884 130.041 1.00 8.27   ?  834  LEU   C O     1 
ATOM   5013 C CB    . LEU   A 1 834  ? 150.735 154.438 129.632 1.00 5.78   ?  834  LEU   C CB    1 
ATOM   5014 C CG    . LEU   A 1 834  ? 150.950 155.906 129.326 1.00 5.85   ?  834  LEU   C CG    1 
ATOM   5015 C CD1   . LEU   A 1 834  ? 151.938 156.028 128.191 1.00 6.10   ?  834  LEU   C CD1   1 
ATOM   5016 C CD2   . LEU   A 1 834  ? 149.629 156.557 128.973 1.00 7.65   ?  834  LEU   C CD2   1 
ATOM   5017 N N     . VAL   A 1 835  ? 149.588 152.168 132.243 1.00 5.27   ?  835  VAL   C N     1 
ATOM   5018 C CA    . VAL   A 1 835  ? 149.494 150.754 132.557 1.00 4.96   ?  835  VAL   C CA    1 
ATOM   5019 C C     . VAL   A 1 835  ? 148.218 150.136 132.010 1.00 6.09   ?  835  VAL   C C     1 
ATOM   5020 O O     . VAL   A 1 835  ? 147.149 150.735 132.092 1.00 10.01  ?  835  VAL   C O     1 
ATOM   5021 C CB    . VAL   A 1 835  ? 149.576 150.573 134.078 1.00 4.76   ?  835  VAL   C CB    1 
ATOM   5022 C CG1   . VAL   A 1 835  ? 149.358 149.133 134.460 1.00 6.40   ?  835  VAL   C CG1   1 
ATOM   5023 C CG2   . VAL   A 1 835  ? 150.933 151.053 134.544 1.00 4.48   ?  835  VAL   C CG2   1 
ATOM   5024 N N     . SER   A 1 836  ? 148.340 148.950 131.425 1.00 6.93   ?  836  SER   C N     1 
ATOM   5025 C CA    . SER   A 1 836  ? 147.198 148.237 130.856 1.00 6.55   ?  836  SER   C CA    1 
ATOM   5026 C C     . SER   A 1 836  ? 146.406 149.091 129.878 1.00 7.69   ?  836  SER   C C     1 
ATOM   5027 O O     . SER   A 1 836  ? 145.189 149.206 130.001 1.00 10.09  ?  836  SER   C O     1 
ATOM   5028 C CB    . SER   A 1 836  ? 146.257 147.776 131.953 1.00 8.98   ?  836  SER   C CB    1 
ATOM   5029 O OG    . SER   A 1 836  ? 146.880 146.895 132.838 1.00 15.05  ?  836  SER   C OG    1 
ATOM   5030 N N     . CYS   A 1 837  ? 147.088 149.691 128.908 1.00 9.34   ?  837  CYS   C N     1 
ATOM   5031 C CA    . CYS   A 1 837  ? 146.430 150.555 127.934 1.00 7.62   ?  837  CYS   C CA    1 
ATOM   5032 C C     . CYS   A 1 837  ? 146.454 149.984 126.529 1.00 8.15   ?  837  CYS   C C     1 
ATOM   5033 O O     . CYS   A 1 837  ? 146.408 150.724 125.552 1.00 9.76   ?  837  CYS   C O     1 
ATOM   5034 C CB    . CYS   A 1 837  ? 147.060 151.938 127.930 1.00 6.84   ?  837  CYS   C CB    1 
ATOM   5035 S SG    . CYS   A 1 837  ? 146.759 152.844 129.425 1.00 8.27   ?  837  CYS   C SG    1 
ATOM   5036 N N     . CYS   A 1 838  ? 146.528 148.668 126.423 1.00 9.35   ?  838  CYS   C N     1 
ATOM   5037 C CA    . CYS   A 1 838  ? 146.514 148.009 125.124 1.00 9.34   ?  838  CYS   C CA    1 
ATOM   5038 C C     . CYS   A 1 838  ? 147.604 148.539 124.211 1.00 8.14   ?  838  CYS   C C     1 
ATOM   5039 O O     . CYS   A 1 838  ? 147.380 148.732 123.017 1.00 11.92  ?  838  CYS   C O     1 
ATOM   5040 C CB    . CYS   A 1 838  ? 145.168 148.215 124.434 1.00 7.91   ?  838  CYS   C CB    1 
ATOM   5041 S SG    . CYS   A 1 838  ? 143.766 147.665 125.395 1.00 10.08  ?  838  CYS   C SG    1 
ATOM   5042 N N     . LEU   A 1 839  ? 148.785 148.766 124.761 1.00 8.22   ?  839  LEU   C N     1 
ATOM   5043 C CA    . LEU   A 1 839  ? 149.876 149.283 123.957 1.00 8.23   ?  839  LEU   C CA    1 
ATOM   5044 C C     . LEU   A 1 839  ? 150.790 148.187 123.480 1.00 11.22  ?  839  LEU   C C     1 
ATOM   5045 O O     . LEU   A 1 839  ? 150.966 147.174 124.156 1.00 12.84  ?  839  LEU   C O     1 
ATOM   5046 C CB    . LEU   A 1 839  ? 150.712 150.268 124.768 1.00 8.25   ?  839  LEU   C CB    1 
ATOM   5047 C CG    . LEU   A 1 839  ? 149.975 151.407 125.377 1.00 8.36   ?  839  LEU   C CG    1 
ATOM   5048 C CD1   . LEU   A 1 839  ? 150.959 152.288 126.127 1.00 6.83   ?  839  LEU   C CD1   1 
ATOM   5049 C CD2   . LEU   A 1 839  ? 149.262 152.158 124.305 1.00 11.00  ?  839  LEU   C CD2   1 
ATOM   5050 N N     . THR   A 1 840  ? 151.431 148.412 122.347 1.00 13.30  ?  840  THR   C N     1 
ATOM   5051 C CA    . THR   A 1 840  ? 152.489 147.509 121.940 1.00 13.53  ?  840  THR   C CA    1 
ATOM   5052 C C     . THR   A 1 840  ? 153.685 148.264 121.388 1.00 15.20  ?  840  THR   C C     1 
ATOM   5053 O O     . THR   A 1 840  ? 153.778 149.484 121.522 1.00 17.69  ?  840  THR   C O     1 
ATOM   5054 C CB    . THR   A 1 840  ? 151.995 146.442 120.957 1.00 13.89  ?  840  THR   C CB    1 
ATOM   5055 O OG1   . THR   A 1 840  ? 153.034 145.465 120.784 1.00 18.60  ?  840  THR   C OG1   1 
ATOM   5056 C CG2   . THR   A 1 840  ? 151.612 147.040 119.632 1.00 16.16  ?  840  THR   C CG2   1 
ATOM   5057 N N     . SER   A 1 841  ? 154.621 147.528 120.804 1.00 15.01  ?  841  SER   C N     1 
ATOM   5058 C CA    . SER   A 1 841  ? 155.908 148.078 120.398 1.00 17.25  ?  841  SER   C CA    1 
ATOM   5059 C C     . SER   A 1 841  ? 155.773 149.214 119.402 1.00 17.88  ?  841  SER   C C     1 
ATOM   5060 O O     . SER   A 1 841  ? 156.650 150.069 119.291 1.00 19.88  ?  841  SER   C O     1 
ATOM   5061 C CB    . SER   A 1 841  ? 156.756 146.983 119.790 1.00 20.72  ?  841  SER   C CB    1 
ATOM   5062 O OG    . SER   A 1 841  ? 156.194 146.527 118.592 1.00 21.75  ?  841  SER   C OG    1 
ATOM   5063 N N     . ALA   A 1 842  ? 154.669 149.235 118.681 1.00 18.20  ?  842  ALA   C N     1 
ATOM   5064 C CA    . ALA   A 1 842  ? 154.443 150.238 117.658 1.00 16.57  ?  842  ALA   C CA    1 
ATOM   5065 C C     . ALA   A 1 842  ? 154.432 151.651 118.232 1.00 18.81  ?  842  ALA   C C     1 
ATOM   5066 O O     . ALA   A 1 842  ? 154.783 152.604 117.539 1.00 22.90  ?  842  ALA   C O     1 
ATOM   5067 C CB    . ALA   A 1 842  ? 153.138 149.961 116.944 1.00 18.16  ?  842  ALA   C CB    1 
ATOM   5068 N N     . CYS   A 1 843  ? 154.009 151.798 119.485 1.00 19.30  ?  843  CYS   C N     1 
ATOM   5069 C CA    . CYS   A 1 843  ? 153.884 153.119 120.091 1.00 17.44  ?  843  CYS   C CA    1 
ATOM   5070 C C     . CYS   A 1 843  ? 155.158 153.560 120.787 1.00 17.69  ?  843  CYS   C C     1 
ATOM   5071 O O     . CYS   A 1 843  ? 155.257 154.698 121.251 1.00 18.46  ?  843  CYS   C O     1 
ATOM   5072 C CB    . CYS   A 1 843  ? 152.776 153.130 121.132 1.00 16.44  ?  843  CYS   C CB    1 
ATOM   5073 S SG    . CYS   A 1 843  ? 153.217 152.270 122.652 1.00 19.44  ?  843  CYS   C SG    1 
ATOM   5074 N N     . CYS   A 1 844  ? 156.126 152.661 120.891 1.00 17.85  ?  844  CYS   C N     1 
ATOM   5075 C CA    . CYS   A 1 844  ? 157.320 152.961 121.658 1.00 15.61  ?  844  CYS   C CA    1 
ATOM   5076 C C     . CYS   A 1 844  ? 158.158 154.013 120.977 1.00 16.51  ?  844  CYS   C C     1 
ATOM   5077 O O     . CYS   A 1 844  ? 158.972 154.675 121.616 1.00 17.63  ?  844  CYS   C O     1 
ATOM   5078 C CB    . CYS   A 1 844  ? 158.140 151.709 121.881 1.00 17.24  ?  844  CYS   C CB    1 
ATOM   5079 S SG    . CYS   A 1 844  ? 157.342 150.555 122.975 1.00 21.51  ?  844  CYS   C SG    1 
ATOM   5080 N N     . GLN   A 1 845  ? 157.949 154.188 119.683 1.00 18.16  ?  845  GLN   C N     1 
ATOM   5081 C CA    . GLN   A 1 845  ? 158.674 155.202 118.951 1.00 18.28  ?  845  GLN   C CA    1 
ATOM   5082 C C     . GLN   A 1 845  ? 158.269 156.591 119.422 1.00 19.74  ?  845  GLN   C C     1 
ATOM   5083 O O     . GLN   A 1 845  ? 159.094 157.504 119.452 1.00 21.86  ?  845  GLN   C O     1 
ATOM   5084 C CB    . GLN   A 1 845  ? 158.437 155.061 117.452 1.00 19.36  ?  845  GLN   C CB    1 
ATOM   5085 C CG    . GLN   A 1 845  ? 159.293 155.985 116.611 1.00 24.44  ?  845  GLN   C CG    1 
ATOM   5086 C CD    . GLN   A 1 845  ? 160.767 155.693 116.763 1.00 31.72  ?  845  GLN   C CD    1 
ATOM   5087 O OE1   . GLN   A 1 845  ? 161.204 154.554 116.587 1.00 26.28  ?  845  GLN   C OE1   1 
ATOM   5088 N NE2   . GLN   A 1 845  ? 161.543 156.718 117.094 1.00 29.84  ?  845  GLN   C NE2   1 
ATOM   5089 N N     . ASP   A 1 846  ? 157.001 156.756 119.793 1.00 19.39  ?  846  ASP   C N     1 
ATOM   5090 C CA    . ASP   A 1 846  ? 156.527 158.068 120.197 1.00 18.34  ?  846  ASP   C CA    1 
ATOM   5091 C C     . ASP   A 1 846  ? 156.862 158.318 121.650 1.00 17.31  ?  846  ASP   C C     1 
ATOM   5092 O O     . ASP   A 1 846  ? 157.214 159.436 122.030 1.00 19.09  ?  846  ASP   C O     1 
ATOM   5093 C CB    . ASP   A 1 846  ? 155.021 158.186 119.989 1.00 18.90  ?  846  ASP   C CB    1 
ATOM   5094 C CG    . ASP   A 1 846  ? 154.619 158.109 118.540 1.00 22.55  ?  846  ASP   C CG    1 
ATOM   5095 O OD1   . ASP   A 1 846  ? 155.080 158.913 117.765 1.00 29.02  ?  846  ASP   C OD1   1 
ATOM   5096 O OD2   . ASP   A 1 846  ? 153.847 157.243 118.213 1.00 22.20  -1 846  ASP   C OD2   1 
ATOM   5097 N N     . LEU   A 1 847  ? 156.799 157.271 122.461 1.00 16.23  ?  847  LEU   C N     1 
ATOM   5098 C CA    . LEU   A 1 847  ? 157.165 157.410 123.856 1.00 14.25  ?  847  LEU   C CA    1 
ATOM   5099 C C     . LEU   A 1 847  ? 158.646 157.733 123.961 1.00 16.21  ?  847  LEU   C C     1 
ATOM   5100 O O     . LEU   A 1 847  ? 159.059 158.530 124.800 1.00 18.74  ?  847  LEU   C O     1 
ATOM   5101 C CB    . LEU   A 1 847  ? 156.853 156.129 124.629 1.00 13.98  ?  847  LEU   C CB    1 
ATOM   5102 C CG    . LEU   A 1 847  ? 155.371 155.799 124.852 1.00 13.37  ?  847  LEU   C CG    1 
ATOM   5103 C CD1   . LEU   A 1 847  ? 155.254 154.388 125.420 1.00 13.75  ?  847  LEU   C CD1   1 
ATOM   5104 C CD2   . LEU   A 1 847  ? 154.758 156.809 125.814 1.00 9.97   ?  847  LEU   C CD2   1 
ATOM   5105 N N     . ALA   A 1 848  ? 159.441 157.110 123.091 1.00 16.85  ?  848  ALA   C N     1 
ATOM   5106 C CA    . ALA   A 1 848  ? 160.878 157.341 123.086 1.00 16.21  ?  848  ALA   C CA    1 
ATOM   5107 C C     . ALA   A 1 848  ? 161.181 158.787 122.741 1.00 18.10  ?  848  ALA   C C     1 
ATOM   5108 O O     . ALA   A 1 848  ? 162.073 159.396 123.343 1.00 20.92  ?  848  ALA   C O     1 
ATOM   5109 C CB    . ALA   A 1 848  ? 161.544 156.409 122.090 1.00 19.93  ?  848  ALA   C CB    1 
ATOM   5110 N N     . SER   A 1 849  ? 160.429 159.357 121.807 1.00 18.53  ?  849  SER   C N     1 
ATOM   5111 C CA    . SER   A 1 849  ? 160.620 160.744 121.425 1.00 18.19  ?  849  SER   C CA    1 
ATOM   5112 C C     . SER   A 1 849  ? 160.319 161.669 122.593 1.00 20.57  ?  849  SER   C C     1 
ATOM   5113 O O     . SER   A 1 849  ? 161.018 162.660 122.806 1.00 23.22  ?  849  SER   C O     1 
ATOM   5114 C CB    . SER   A 1 849  ? 159.739 161.095 120.248 1.00 21.39  ?  849  SER   C CB    1 
ATOM   5115 O OG    . SER   A 1 849  ? 160.128 160.389 119.103 1.00 26.29  ?  849  SER   C OG    1 
ATOM   5116 N N     . VAL   A 1 850  ? 159.294 161.326 123.369 1.00 19.47  ?  850  VAL   C N     1 
ATOM   5117 C CA    . VAL   A 1 850  ? 158.955 162.128 124.536 1.00 17.58  ?  850  VAL   C CA    1 
ATOM   5118 C C     . VAL   A 1 850  ? 160.083 162.078 125.551 1.00 18.79  ?  850  VAL   C C     1 
ATOM   5119 O O     . VAL   A 1 850  ? 160.493 163.107 126.084 1.00 22.30  ?  850  VAL   C O     1 
ATOM   5120 C CB    . VAL   A 1 850  ? 157.651 161.634 125.195 1.00 16.05  ?  850  VAL   C CB    1 
ATOM   5121 C CG1   . VAL   A 1 850  ? 157.429 162.353 126.516 1.00 14.34  ?  850  VAL   C CG1   1 
ATOM   5122 C CG2   . VAL   A 1 850  ? 156.480 161.892 124.270 1.00 17.43  ?  850  VAL   C CG2   1 
ATOM   5123 N N     . LEU   A 1 851  ? 160.615 160.890 125.808 1.00 18.69  ?  851  LEU   C N     1 
ATOM   5124 C CA    . LEU   A 1 851  ? 161.704 160.771 126.765 1.00 19.09  ?  851  LEU   C CA    1 
ATOM   5125 C C     . LEU   A 1 851  ? 162.920 161.558 126.308 1.00 20.69  ?  851  LEU   C C     1 
ATOM   5126 O O     . LEU   A 1 851  ? 163.602 162.193 127.113 1.00 22.16  ?  851  LEU   C O     1 
ATOM   5127 C CB    . LEU   A 1 851  ? 162.109 159.304 126.946 1.00 16.88  ?  851  LEU   C CB    1 
ATOM   5128 C CG    . LEU   A 1 851  ? 161.102 158.392 127.649 1.00 16.39  ?  851  LEU   C CG    1 
ATOM   5129 C CD1   . LEU   A 1 851  ? 161.597 156.952 127.559 1.00 15.54  ?  851  LEU   C CD1   1 
ATOM   5130 C CD2   . LEU   A 1 851  ? 160.951 158.819 129.101 1.00 16.84  ?  851  LEU   C CD2   1 
ATOM   5131 N N     . SER   A 1 852  ? 163.170 161.545 125.006 1.00 21.58  ?  852  SER   C N     1 
ATOM   5132 C CA    . SER   A 1 852  ? 164.317 162.235 124.441 1.00 22.93  ?  852  SER   C CA    1 
ATOM   5133 C C     . SER   A 1 852  ? 164.293 163.740 124.685 1.00 23.69  ?  852  SER   C C     1 
ATOM   5134 O O     . SER   A 1 852  ? 165.321 164.328 125.026 1.00 25.34  ?  852  SER   C O     1 
ATOM   5135 C CB    . SER   A 1 852  ? 164.390 161.979 122.951 1.00 25.76  ?  852  SER   C CB    1 
ATOM   5136 O OG    . SER   A 1 852  ? 165.490 162.633 122.382 1.00 33.00  ?  852  SER   C OG    1 
ATOM   5137 N N     . THR   A 1 853  ? 163.136 164.375 124.492 1.00 24.65  ?  853  THR   C N     1 
ATOM   5138 C CA    . THR   A 1 853  ? 163.085 165.831 124.583 1.00 26.16  ?  853  THR   C CA    1 
ATOM   5139 C C     . THR   A 1 853  ? 162.383 166.405 125.816 1.00 25.93  ?  853  THR   C C     1 
ATOM   5140 O O     . THR   A 1 853  ? 162.581 167.579 126.133 1.00 27.73  ?  853  THR   C O     1 
ATOM   5141 C CB    . THR   A 1 853  ? 162.412 166.422 123.337 1.00 28.84  ?  853  THR   C CB    1 
ATOM   5142 O OG1   . THR   A 1 853  ? 161.054 165.975 123.269 1.00 26.02  ?  853  THR   C OG1   1 
ATOM   5143 C CG2   . THR   A 1 853  ? 163.148 165.974 122.089 1.00 36.05  ?  853  THR   C CG2   1 
ATOM   5144 N N     . SER   A 1 854  ? 161.555 165.624 126.502 1.00 24.07  ?  854  SER   C N     1 
ATOM   5145 C CA    . SER   A 1 854  ? 160.800 166.181 127.624 1.00 22.08  ?  854  SER   C CA    1 
ATOM   5146 C C     . SER   A 1 854  ? 161.703 166.665 128.744 1.00 22.08  ?  854  SER   C C     1 
ATOM   5147 O O     . SER   A 1 854  ? 162.574 165.939 129.228 1.00 25.32  ?  854  SER   C O     1 
ATOM   5148 C CB    . SER   A 1 854  ? 159.815 165.170 128.171 1.00 19.91  ?  854  SER   C CB    1 
ATOM   5149 O OG    . SER   A 1 854  ? 159.189 165.656 129.339 1.00 21.25  ?  854  SER   C OG    1 
ATOM   5150 N N     . HIS   A 1 855  ? 161.464 167.894 129.179 1.00 22.06  ?  855  HIS   C N     1 
ATOM   5151 C CA    . HIS   A 1 855  ? 162.244 168.504 130.237 1.00 21.68  ?  855  HIS   C CA    1 
ATOM   5152 C C     . HIS   A 1 855  ? 161.696 168.157 131.609 1.00 22.82  ?  855  HIS   C C     1 
ATOM   5153 O O     . HIS   A 1 855  ? 162.322 168.455 132.626 1.00 25.13  ?  855  HIS   C O     1 
ATOM   5154 C CB    . HIS   A 1 855  ? 162.238 170.022 130.079 1.00 22.53  ?  855  HIS   C CB    1 
ATOM   5155 C CG    . HIS   A 1 855  ? 160.864 170.592 130.188 1.00 27.41  ?  855  HIS   C CG    1 
ATOM   5156 N ND1   . HIS   A 1 855  ? 159.925 170.458 129.186 1.00 28.23  ?  855  HIS   C ND1   1 
ATOM   5157 C CD2   . HIS   A 1 855  ? 160.256 171.279 131.185 1.00 34.83  ?  855  HIS   C CD2   1 
ATOM   5158 C CE1   . HIS   A 1 855  ? 158.798 171.041 129.563 1.00 27.44  ?  855  HIS   C CE1   1 
ATOM   5159 N NE2   . HIS   A 1 855  ? 158.973 171.546 130.771 1.00 28.36  ?  855  HIS   C NE2   1 
ATOM   5160 N N     . SER   A 1 856  ? 160.502 167.572 131.644 1.00 21.17  ?  856  SER   C N     1 
ATOM   5161 C CA    . SER   A 1 856  ? 159.825 167.366 132.915 1.00 16.80  ?  856  SER   C CA    1 
ATOM   5162 C C     . SER   A 1 856  ? 159.430 165.928 133.220 1.00 12.52  ?  856  SER   C C     1 
ATOM   5163 O O     . SER   A 1 856  ? 159.177 165.601 134.375 1.00 14.10  ?  856  SER   C O     1 
ATOM   5164 C CB    . SER   A 1 856  ? 158.581 168.224 132.954 1.00 17.44  ?  856  SER   C CB    1 
ATOM   5165 O OG    . SER   A 1 856  ? 157.667 167.821 131.969 1.00 17.71  ?  856  SER   C OG    1 
ATOM   5166 N N     . LEU   A 1 857  ? 159.352 165.064 132.217 1.00 11.67  ?  857  LEU   C N     1 
ATOM   5167 C CA    . LEU   A 1 857  ? 158.841 163.725 132.491 1.00 8.69   ?  857  LEU   C CA    1 
ATOM   5168 C C     . LEU   A 1 857  ? 159.903 162.865 133.148 1.00 10.09  ?  857  LEU   C C     1 
ATOM   5169 O O     . LEU   A 1 857  ? 160.941 162.585 132.550 1.00 14.87  ?  857  LEU   C O     1 
ATOM   5170 C CB    . LEU   A 1 857  ? 158.362 163.054 131.197 1.00 9.06   ?  857  LEU   C CB    1 
ATOM   5171 C CG    . LEU   A 1 857  ? 157.761 161.627 131.333 1.00 7.63   ?  857  LEU   C CG    1 
ATOM   5172 C CD1   . LEU   A 1 857  ? 156.464 161.684 132.132 1.00 6.77   ?  857  LEU   C CD1   1 
ATOM   5173 C CD2   . LEU   A 1 857  ? 157.509 161.054 129.949 1.00 10.25  ?  857  LEU   C CD2   1 
ATOM   5174 N N     . THR   A 1 858  ? 159.642 162.445 134.385 1.00 8.97   ?  858  THR   C N     1 
ATOM   5175 C CA    . THR   A 1 858  ? 160.610 161.661 135.134 1.00 8.67   ?  858  THR   C CA    1 
ATOM   5176 C C     . THR   A 1 858  ? 160.082 160.280 135.507 1.00 8.87   ?  858  THR   C C     1 
ATOM   5177 O O     . THR   A 1 858  ? 160.859 159.348 135.711 1.00 10.99  ?  858  THR   C O     1 
ATOM   5178 C CB    . THR   A 1 858  ? 161.040 162.405 136.407 1.00 12.53  ?  858  THR   C CB    1 
ATOM   5179 O OG1   . THR   A 1 858  ? 159.902 162.614 137.247 1.00 13.61  ?  858  THR   C OG1   1 
ATOM   5180 C CG2   . THR   A 1 858  ? 161.649 163.748 136.053 1.00 13.49  ?  858  THR   C CG2   1 
ATOM   5181 N N     . ARG   A 1 859  ? 158.766 160.132 135.579 1.00 7.92   ?  859  ARG   C N     1 
ATOM   5182 C CA    . ARG   A 1 859  ? 158.173 158.856 135.962 1.00 5.47   ?  859  ARG   C CA    1 
ATOM   5183 C C     . ARG   A 1 859  ? 157.313 158.296 134.845 1.00 4.49   ?  859  ARG   C C     1 
ATOM   5184 O O     . ARG   A 1 859  ? 156.311 158.905 134.471 1.00 6.83   ?  859  ARG   C O     1 
ATOM   5185 C CB    . ARG   A 1 859  ? 157.290 159.024 137.182 1.00 7.12   ?  859  ARG   C CB    1 
ATOM   5186 C CG    . ARG   A 1 859  ? 157.959 158.998 138.539 1.00 8.31   ?  859  ARG   C CG    1 
ATOM   5187 C CD    . ARG   A 1 859  ? 158.726 160.223 138.808 1.00 11.02  ?  859  ARG   C CD    1 
ATOM   5188 N NE    . ARG   A 1 859  ? 158.963 160.405 140.229 1.00 12.54  ?  859  ARG   C NE    1 
ATOM   5189 C CZ    . ARG   A 1 859  ? 159.745 161.362 140.754 1.00 14.29  ?  859  ARG   C CZ    1 
ATOM   5190 N NH1   . ARG   A 1 859  ? 160.356 162.209 139.965 1.00 18.26  1  859  ARG   C NH1   1 
ATOM   5191 N NH2   . ARG   A 1 859  ? 159.902 161.455 142.064 1.00 21.06  ?  859  ARG   C NH2   1 
ATOM   5192 N N     . LEU   A 1 860  ? 157.683 157.136 134.322 1.00 4.11   ?  860  LEU   C N     1 
ATOM   5193 C CA    . LEU   A 1 860  ? 156.908 156.534 133.247 1.00 4.57   ?  860  LEU   C CA    1 
ATOM   5194 C C     . LEU   A 1 860  ? 156.573 155.083 133.545 1.00 4.55   ?  860  LEU   C C     1 
ATOM   5195 O O     . LEU   A 1 860  ? 157.465 154.239 133.631 1.00 6.60   ?  860  LEU   C O     1 
ATOM   5196 C CB    . LEU   A 1 860  ? 157.685 156.628 131.927 1.00 6.76   ?  860  LEU   C CB    1 
ATOM   5197 C CG    . LEU   A 1 860  ? 157.036 155.956 130.708 1.00 6.18   ?  860  LEU   C CG    1 
ATOM   5198 C CD1   . LEU   A 1 860  ? 155.705 156.639 130.383 1.00 6.54   ?  860  LEU   C CD1   1 
ATOM   5199 C CD2   . LEU   A 1 860  ? 157.985 156.042 129.522 1.00 7.21   ?  860  LEU   C CD2   1 
ATOM   5200 N N     . TYR   A 1 861  ? 155.285 154.788 133.671 1.00 4.84   ?  861  TYR   C N     1 
ATOM   5201 C CA    . TYR   A 1 861  ? 154.845 153.432 133.972 1.00 4.67   ?  861  TYR   C CA    1 
ATOM   5202 C C     . TYR   A 1 861  ? 154.070 152.857 132.801 1.00 5.02   ?  861  TYR   C C     1 
ATOM   5203 O O     . TYR   A 1 861  ? 153.017 153.374 132.435 1.00 7.12   ?  861  TYR   C O     1 
ATOM   5204 C CB    . TYR   A 1 861  ? 153.990 153.427 135.232 1.00 5.44   ?  861  TYR   C CB    1 
ATOM   5205 C CG    . TYR   A 1 861  ? 154.691 154.020 136.417 1.00 6.02   ?  861  TYR   C CG    1 
ATOM   5206 C CD1   . TYR   A 1 861  ? 154.506 155.351 136.714 1.00 5.44   ?  861  TYR   C CD1   1 
ATOM   5207 C CD2   . TYR   A 1 861  ? 155.521 153.248 137.199 1.00 6.65   ?  861  TYR   C CD2   1 
ATOM   5208 C CE1   . TYR   A 1 861  ? 155.139 155.909 137.790 1.00 5.35   ?  861  TYR   C CE1   1 
ATOM   5209 C CE2   . TYR   A 1 861  ? 156.163 153.810 138.275 1.00 5.76   ?  861  TYR   C CE2   1 
ATOM   5210 C CZ    . TYR   A 1 861  ? 155.972 155.136 138.569 1.00 5.46   ?  861  TYR   C CZ    1 
ATOM   5211 O OH    . TYR   A 1 861  ? 156.606 155.698 139.644 1.00 11.40  ?  861  TYR   C OH    1 
ATOM   5212 N N     . VAL   A 1 862  ? 154.604 151.813 132.182 1.00 5.11   ?  862  VAL   C N     1 
ATOM   5213 C CA    . VAL   A 1 862  ? 153.992 151.263 130.978 1.00 5.95   ?  862  VAL   C CA    1 
ATOM   5214 C C     . VAL   A 1 862  ? 153.795 149.757 131.046 1.00 6.21   ?  862  VAL   C C     1 
ATOM   5215 O O     . VAL   A 1 862  ? 153.669 149.101 130.014 1.00 10.31  ?  862  VAL   C O     1 
ATOM   5216 C CB    . VAL   A 1 862  ? 154.837 151.614 129.741 1.00 5.82   ?  862  VAL   C CB    1 
ATOM   5217 C CG1   . VAL   A 1 862  ? 154.821 153.099 129.503 1.00 6.41   ?  862  VAL   C CG1   1 
ATOM   5218 C CG2   . VAL   A 1 862  ? 156.244 151.138 129.949 1.00 8.10   ?  862  VAL   C CG2   1 
ATOM   5219 N N     . GLY   A 1 863  ? 153.772 149.210 132.248 1.00 5.25   ?  863  GLY   C N     1 
ATOM   5220 C CA    . GLY   A 1 863  ? 153.637 147.772 132.410 1.00 6.63   ?  863  GLY   C CA    1 
ATOM   5221 C C     . GLY   A 1 863  ? 152.236 147.298 132.069 1.00 6.82   ?  863  GLY   C C     1 
ATOM   5222 O O     . GLY   A 1 863  ? 151.339 148.107 131.837 1.00 8.61   ?  863  GLY   C O     1 
ATOM   5223 N N     . GLU   A 1 864  ? 152.060 145.983 132.044 1.00 9.09   ?  864  GLU   C N     1 
ATOM   5224 C CA    . GLU   A 1 864  ? 150.793 145.339 131.711 1.00 8.36   ?  864  GLU   C CA    1 
ATOM   5225 C C     . GLU   A 1 864  ? 150.372 145.632 130.277 1.00 9.72   ?  864  GLU   C C     1 
ATOM   5226 O O     . GLU   A 1 864  ? 149.194 145.540 129.933 1.00 12.54  ?  864  GLU   C O     1 
ATOM   5227 C CB    . GLU   A 1 864  ? 149.688 145.783 132.667 1.00 10.83  ?  864  GLU   C CB    1 
ATOM   5228 C CG    . GLU   A 1 864  ? 150.000 145.631 134.155 1.00 13.35  ?  864  GLU   C CG    1 
ATOM   5229 C CD    . GLU   A 1 864  ? 150.107 144.215 134.598 1.00 18.57  ?  864  GLU   C CD    1 
ATOM   5230 O OE1   . GLU   A 1 864  ? 149.607 143.358 133.912 1.00 22.48  ?  864  GLU   C OE1   1 
ATOM   5231 O OE2   . GLU   A 1 864  ? 150.692 143.979 135.627 1.00 22.51  -1 864  GLU   C OE2   1 
ATOM   5232 N N     . ASN   A 1 865  ? 151.344 145.940 129.433 1.00 9.71   ?  865  ASN   C N     1 
ATOM   5233 C CA    . ASN   A 1 865  ? 151.109 146.161 128.017 1.00 9.57   ?  865  ASN   C CA    1 
ATOM   5234 C C     . ASN   A 1 865  ? 151.911 145.158 127.202 1.00 10.77  ?  865  ASN   C C     1 
ATOM   5235 O O     . ASN   A 1 865  ? 152.633 144.335 127.757 1.00 12.59  ?  865  ASN   C O     1 
ATOM   5236 C CB    . ASN   A 1 865  ? 151.471 147.575 127.634 1.00 9.14   ?  865  ASN   C CB    1 
ATOM   5237 C CG    . ASN   A 1 865  ? 150.534 148.603 128.167 1.00 7.47   ?  865  ASN   C CG    1 
ATOM   5238 O OD1   . ASN   A 1 865  ? 149.360 148.672 127.777 1.00 9.01   ?  865  ASN   C OD1   1 
ATOM   5239 N ND2   . ASN   A 1 865  ? 151.036 149.426 129.040 1.00 7.36   ?  865  ASN   C ND2   1 
ATOM   5240 N N     . ALA   A 1 866  ? 151.793 145.223 125.885 1.00 12.96  ?  866  ALA   C N     1 
ATOM   5241 C CA    . ALA   A 1 866  ? 152.519 144.313 125.010 1.00 11.31  ?  866  ALA   C CA    1 
ATOM   5242 C C     . ALA   A 1 866  ? 153.774 144.970 124.467 1.00 10.58  ?  866  ALA   C C     1 
ATOM   5243 O O     . ALA   A 1 866  ? 154.017 144.969 123.257 1.00 14.55  ?  866  ALA   C O     1 
ATOM   5244 C CB    . ALA   A 1 866  ? 151.631 143.860 123.866 1.00 13.56  ?  866  ALA   C CB    1 
ATOM   5245 N N     . LEU   A 1 867  ? 154.575 145.524 125.363 1.00 11.91  ?  867  LEU   C N     1 
ATOM   5246 C CA    . LEU   A 1 867  ? 155.832 146.145 124.982 1.00 12.80  ?  867  LEU   C CA    1 
ATOM   5247 C C     . LEU   A 1 867  ? 156.943 145.131 125.099 1.00 16.63  ?  867  LEU   C C     1 
ATOM   5248 O O     . LEU   A 1 867  ? 157.651 145.088 126.103 1.00 22.89  ?  867  LEU   C O     1 
ATOM   5249 C CB    . LEU   A 1 867  ? 156.154 147.349 125.874 1.00 12.53  ?  867  LEU   C CB    1 
ATOM   5250 C CG    . LEU   A 1 867  ? 155.569 148.684 125.447 1.00 14.07  ?  867  LEU   C CG    1 
ATOM   5251 C CD1   . LEU   A 1 867  ? 154.113 148.747 125.802 1.00 13.63  ?  867  LEU   C CD1   1 
ATOM   5252 C CD2   . LEU   A 1 867  ? 156.346 149.796 126.138 1.00 16.71  ?  867  LEU   C CD2   1 
ATOM   5253 N N     . GLY   A 1 868  ? 157.081 144.297 124.082 1.00 14.99  ?  868  GLY   C N     1 
ATOM   5254 C CA    . GLY   A 1 868  ? 158.026 143.201 124.149 1.00 15.90  ?  868  GLY   C CA    1 
ATOM   5255 C C     . GLY   A 1 868  ? 159.435 143.721 123.974 1.00 18.81  ?  868  GLY   C C     1 
ATOM   5256 O O     . GLY   A 1 868  ? 159.665 144.930 123.968 1.00 20.73  ?  868  GLY   C O     1 
ATOM   5257 N N     . ASP   A 1 869  ? 160.377 142.810 123.809 1.00 19.80  ?  869  ASP   C N     1 
ATOM   5258 C CA    . ASP   A 1 869  ? 161.785 143.169 123.753 1.00 20.18  ?  869  ASP   C CA    1 
ATOM   5259 C C     . ASP   A 1 869  ? 162.072 144.260 122.733 1.00 19.37  ?  869  ASP   C C     1 
ATOM   5260 O O     . ASP   A 1 869  ? 162.917 145.125 122.967 1.00 20.65  ?  869  ASP   C O     1 
ATOM   5261 C CB    . ASP   A 1 869  ? 162.604 141.933 123.416 1.00 26.01  ?  869  ASP   C CB    1 
ATOM   5262 C CG    . ASP   A 1 869  ? 162.592 140.918 124.529 1.00 28.18  ?  869  ASP   C CG    1 
ATOM   5263 O OD1   . ASP   A 1 869  ? 162.273 141.272 125.638 1.00 25.92  ?  869  ASP   C OD1   1 
ATOM   5264 O OD2   . ASP   A 1 869  ? 162.848 139.783 124.254 1.00 30.72  -1 869  ASP   C OD2   1 
ATOM   5265 N N     . SER   A 1 870  ? 161.374 144.224 121.605 1.00 18.30  ?  870  SER   C N     1 
ATOM   5266 C CA    . SER   A 1 870  ? 161.580 145.221 120.570 1.00 17.90  ?  870  SER   C CA    1 
ATOM   5267 C C     . SER   A 1 870  ? 161.102 146.599 121.007 1.00 20.67  ?  870  SER   C C     1 
ATOM   5268 O O     . SER   A 1 870  ? 161.663 147.615 120.596 1.00 22.00  ?  870  SER   C O     1 
ATOM   5269 C CB    . SER   A 1 870  ? 160.850 144.811 119.310 1.00 19.35  ?  870  SER   C CB    1 
ATOM   5270 O OG    . SER   A 1 870  ? 159.467 144.787 119.520 1.00 19.93  ?  870  SER   C OG    1 
ATOM   5271 N N     . GLY   A 1 871  ? 160.068 146.639 121.843 1.00 20.64  ?  871  GLY   C N     1 
ATOM   5272 C CA    . GLY   A 1 871  ? 159.530 147.905 122.319 1.00 17.42  ?  871  GLY   C CA    1 
ATOM   5273 C C     . GLY   A 1 871  ? 160.490 148.528 123.308 1.00 16.88  ?  871  GLY   C C     1 
ATOM   5274 O O     . GLY   A 1 871  ? 160.758 149.733 123.281 1.00 18.52  ?  871  GLY   C O     1 
ATOM   5275 N N     . VAL   A 1 872  ? 161.031 147.693 124.175 1.00 18.65  ?  872  VAL   C N     1 
ATOM   5276 C CA    . VAL   A 1 872  ? 161.953 148.146 125.191 1.00 17.42  ?  872  VAL   C CA    1 
ATOM   5277 C C     . VAL   A 1 872  ? 163.223 148.684 124.556 1.00 20.13  ?  872  VAL   C C     1 
ATOM   5278 O O     . VAL   A 1 872  ? 163.731 149.719 124.955 1.00 21.66  ?  872  VAL   C O     1 
ATOM   5279 C CB    . VAL   A 1 872  ? 162.263 147.019 126.169 1.00 18.48  ?  872  VAL   C CB    1 
ATOM   5280 C CG1   . VAL   A 1 872  ? 163.361 147.427 127.142 1.00 21.62  ?  872  VAL   C CG1   1 
ATOM   5281 C CG2   . VAL   A 1 872  ? 161.003 146.684 126.901 1.00 17.55  ?  872  VAL   C CG2   1 
ATOM   5282 N N     . ALA   A 1 873  ? 163.704 147.968 123.540 1.00 20.90  ?  873  ALA   C N     1 
ATOM   5283 C CA    . ALA   A 1 873  ? 164.917 148.410 122.846 1.00 20.49  ?  873  ALA   C CA    1 
ATOM   5284 C C     . ALA   A 1 873  ? 164.710 149.791 122.256 1.00 21.08  ?  873  ALA   C C     1 
ATOM   5285 O O     . ALA   A 1 873  ? 165.659 150.610 122.259 1.00 23.58  ?  873  ALA   C O     1 
ATOM   5286 C CB    . ALA   A 1 873  ? 165.233 147.414 121.741 1.00 24.28  ?  873  ALA   C CB    1 
ATOM   5287 N N     . ILE   A 1 874  ? 163.532 150.106 121.765 1.00 20.08  ?  874  ILE   C N     1 
ATOM   5288 C CA    . ILE   A 1 874  ? 163.238 151.413 121.220 1.00 18.30  ?  874  ILE   C CA    1 
ATOM   5289 C C     . ILE   A 1 874  ? 163.321 152.475 122.305 1.00 21.01  ?  874  ILE   C C     1 
ATOM   5290 O O     . ILE   A 1 874  ? 163.939 153.513 122.138 1.00 23.10  ?  874  ILE   C O     1 
ATOM   5291 C CB    . ILE   A 1 874  ? 161.870 151.468 120.542 1.00 16.59  ?  874  ILE   C CB    1 
ATOM   5292 C CG1   . ILE   A 1 874  ? 161.865 150.591 119.308 1.00 18.36  ?  874  ILE   C CG1   1 
ATOM   5293 C CG2   . ILE   A 1 874  ? 161.515 152.904 120.180 1.00 20.80  ?  874  ILE   C CG2   1 
ATOM   5294 C CD1   . ILE   A 1 874  ? 160.480 150.294 118.788 1.00 19.59  ?  874  ILE   C CD1   1 
ATOM   5295 N N     . LEU   A 1 875  ? 162.680 152.183 123.440 1.00 19.70  ?  875  LEU   C N     1 
ATOM   5296 C CA    . LEU   A 1 875  ? 162.691 153.136 124.544 1.00 17.34  ?  875  LEU   C CA    1 
ATOM   5297 C C     . LEU   A 1 875  ? 164.095 153.324 125.085 1.00 21.08  ?  875  LEU   C C     1 
ATOM   5298 O O     . LEU   A 1 875  ? 164.486 154.442 125.441 1.00 22.18  ?  875  LEU   C O     1 
ATOM   5299 C CB    . LEU   A 1 875  ? 161.791 152.635 125.685 1.00 16.28  ?  875  LEU   C CB    1 
ATOM   5300 C CG    . LEU   A 1 875  ? 160.282 152.559 125.398 1.00 15.45  ?  875  LEU   C CG    1 
ATOM   5301 C CD1   . LEU   A 1 875  ? 159.588 151.896 126.579 1.00 16.35  ?  875  LEU   C CD1   1 
ATOM   5302 C CD2   . LEU   A 1 875  ? 159.726 153.943 125.160 1.00 16.69  ?  875  LEU   C CD2   1 
ATOM   5303 N N     . CYS   A 1 876  ? 164.860 152.241 125.141 1.00 23.00  ?  876  CYS   C N     1 
ATOM   5304 C CA    . CYS   A 1 876  ? 166.213 152.267 125.670 1.00 22.36  ?  876  CYS   C CA    1 
ATOM   5305 C C     . CYS   A 1 876  ? 167.151 153.078 124.790 1.00 23.89  ?  876  CYS   C C     1 
ATOM   5306 O O     . CYS   A 1 876  ? 168.061 153.744 125.286 1.00 26.09  ?  876  CYS   C O     1 
ATOM   5307 C CB    . CYS   A 1 876  ? 166.747 150.857 125.833 1.00 24.84  ?  876  CYS   C CB    1 
ATOM   5308 S SG    . CYS   A 1 876  ? 165.944 149.941 127.159 1.00 28.80  ?  876  CYS   C SG    1 
ATOM   5309 N N     . GLU   A 1 877  ? 166.913 153.055 123.483 1.00 24.28  ?  877  GLU   C N     1 
ATOM   5310 C CA    . GLU   A 1 877  ? 167.756 153.789 122.555 1.00 25.98  ?  877  GLU   C CA    1 
ATOM   5311 C C     . GLU   A 1 877  ? 167.824 155.264 122.925 1.00 27.63  ?  877  GLU   C C     1 
ATOM   5312 O O     . GLU   A 1 877  ? 168.854 155.909 122.743 1.00 29.18  ?  877  GLU   C O     1 
ATOM   5313 C CB    . GLU   A 1 877  ? 167.249 153.633 121.123 1.00 27.51  ?  877  GLU   C CB    1 
ATOM   5314 C CG    . GLU   A 1 877  ? 168.118 154.309 120.062 1.00 35.81  ?  877  GLU   C CG    1 
ATOM   5315 C CD    . GLU   A 1 877  ? 169.496 153.698 119.936 1.00 49.03  ?  877  GLU   C CD    1 
ATOM   5316 O OE1   . GLU   A 1 877  ? 169.694 152.605 120.414 1.00 42.53  ?  877  GLU   C OE1   1 
ATOM   5317 O OE2   . GLU   A 1 877  ? 170.352 154.330 119.365 1.00 46.58  -1 877  GLU   C OE2   1 
ATOM   5318 N N     . LYS   A 1 878  ? 166.723 155.810 123.435 1.00 26.67  ?  878  LYS   C N     1 
ATOM   5319 C CA    . LYS   A 1 878  ? 166.721 157.211 123.829 1.00 24.44  ?  878  LYS   C CA    1 
ATOM   5320 C C     . LYS   A 1 878  ? 166.920 157.364 125.336 1.00 24.55  ?  878  LYS   C C     1 
ATOM   5321 O O     . LYS   A 1 878  ? 167.513 158.340 125.791 1.00 27.31  ?  878  LYS   C O     1 
ATOM   5322 C CB    . LYS   A 1 878  ? 165.420 157.889 123.400 1.00 23.80  ?  878  LYS   C CB    1 
ATOM   5323 C CG    . LYS   A 1 878  ? 165.134 157.856 121.887 1.00 24.65  ?  878  LYS   C CG    1 
ATOM   5324 C CD    . LYS   A 1 878  ? 166.208 158.571 121.069 1.00 31.62  ?  878  LYS   C CD    1 
ATOM   5325 C CE    . LYS   A 1 878  ? 165.834 158.617 119.589 1.00 30.43  ?  878  LYS   C CE    1 
ATOM   5326 N NZ    . LYS   A 1 878  ? 166.914 159.226 118.757 1.00 26.64  1  878  LYS   C NZ    1 
ATOM   5327 N N     . ALA   A 1 879  ? 166.440 156.396 126.117 1.00 23.97  ?  879  ALA   C N     1 
ATOM   5328 C CA    . ALA   A 1 879  ? 166.548 156.471 127.572 1.00 22.24  ?  879  ALA   C CA    1 
ATOM   5329 C C     . ALA   A 1 879  ? 168.004 156.455 128.016 1.00 25.57  ?  879  ALA   C C     1 
ATOM   5330 O O     . ALA   A 1 879  ? 168.350 157.028 129.048 1.00 28.32  ?  879  ALA   C O     1 
ATOM   5331 C CB    . ALA   A 1 879  ? 165.796 155.330 128.229 1.00 22.40  ?  879  ALA   C CB    1 
ATOM   5332 N N     . LYS   A 1 880  ? 168.863 155.797 127.240 1.00 25.83  ?  880  LYS   C N     1 
ATOM   5333 C CA    . LYS   A 1 880  ? 170.283 155.717 127.568 1.00 25.31  ?  880  LYS   C CA    1 
ATOM   5334 C C     . LYS   A 1 880  ? 170.985 157.062 127.440 1.00 25.07  ?  880  LYS   C C     1 
ATOM   5335 O O     . LYS   A 1 880  ? 172.110 157.222 127.904 1.00 28.36  ?  880  LYS   C O     1 
ATOM   5336 C CB    . LYS   A 1 880  ? 170.993 154.691 126.683 1.00 28.41  ?  880  LYS   C CB    1 
ATOM   5337 C CG    . LYS   A 1 880  ? 171.164 155.112 125.233 1.00 30.70  ?  880  LYS   C CG    1 
ATOM   5338 C CD    . LYS   A 1 880  ? 171.842 154.025 124.420 1.00 31.66  ?  880  LYS   C CD    1 
ATOM   5339 C CE    . LYS   A 1 880  ? 172.029 154.456 122.972 1.00 41.07  ?  880  LYS   C CE    1 
ATOM   5340 N NZ    . LYS   A 1 880  ? 172.687 153.401 122.155 1.00 42.82  1  880  LYS   C NZ    1 
ATOM   5341 N N     . ASN   A 1 881  ? 170.355 158.022 126.781 1.00 26.31  ?  881  ASN   C N     1 
ATOM   5342 C CA    . ASN   A 1 881  ? 170.968 159.325 126.605 1.00 27.98  ?  881  ASN   C CA    1 
ATOM   5343 C C     . ASN   A 1 881  ? 171.176 159.975 127.971 1.00 28.56  ?  881  ASN   C C     1 
ATOM   5344 O O     . ASN   A 1 881  ? 170.219 160.121 128.730 1.00 29.77  ?  881  ASN   C O     1 
ATOM   5345 C CB    . ASN   A 1 881  ? 170.108 160.201 125.711 1.00 30.48  ?  881  ASN   C CB    1 
ATOM   5346 C CG    . ASN   A 1 881  ? 170.767 161.500 125.341 1.00 34.12  ?  881  ASN   C CG    1 
ATOM   5347 O OD1   . ASN   A 1 881  ? 171.161 162.291 126.207 1.00 32.24  ?  881  ASN   C OD1   1 
ATOM   5348 N ND2   . ASN   A 1 881  ? 170.896 161.740 124.060 1.00 38.57  ?  881  ASN   C ND2   1 
ATOM   5349 N N     . PRO   A 1 882  ? 172.396 160.410 128.301 1.00 30.52  ?  882  PRO   C N     1 
ATOM   5350 C CA    . PRO   A 1 882  ? 172.796 160.945 129.591 1.00 32.05  ?  882  PRO   C CA    1 
ATOM   5351 C C     . PRO   A 1 882  ? 172.028 162.209 129.969 1.00 33.21  ?  882  PRO   C C     1 
ATOM   5352 O O     . PRO   A 1 882  ? 172.049 162.623 131.128 1.00 35.34  ?  882  PRO   C O     1 
ATOM   5353 C CB    . PRO   A 1 882  ? 174.291 161.222 129.387 1.00 29.76  ?  882  PRO   C CB    1 
ATOM   5354 C CG    . PRO   A 1 882  ? 174.467 161.363 127.897 1.00 32.57  ?  882  PRO   C CG    1 
ATOM   5355 C CD    . PRO   A 1 882  ? 173.471 160.403 127.297 1.00 32.31  ?  882  PRO   C CD    1 
ATOM   5356 N N     . GLN   A 1 883  ? 171.363 162.827 128.997 1.00 31.77  ?  883  GLN   C N     1 
ATOM   5357 C CA    . GLN   A 1 883  ? 170.593 164.038 129.249 1.00 32.04  ?  883  GLN   C CA    1 
ATOM   5358 C C     . GLN   A 1 883  ? 169.119 163.738 129.516 1.00 29.68  ?  883  GLN   C C     1 
ATOM   5359 O O     . GLN   A 1 883  ? 168.328 164.654 129.738 1.00 30.17  ?  883  GLN   C O     1 
ATOM   5360 C CB    . GLN   A 1 883  ? 170.718 164.998 128.067 1.00 35.26  ?  883  GLN   C CB    1 
ATOM   5361 C CG    . GLN   A 1 883  ? 172.141 165.428 127.775 1.00 36.39  ?  883  GLN   C CG    1 
ATOM   5362 C CD    . GLN   A 1 883  ? 172.771 166.141 128.943 1.00 39.75  ?  883  GLN   C CD    1 
ATOM   5363 O OE1   . GLN   A 1 883  ? 172.240 167.137 129.440 1.00 33.72  ?  883  GLN   C OE1   1 
ATOM   5364 N NE2   . GLN   A 1 883  ? 173.909 165.636 129.396 1.00 42.59  ?  883  GLN   C NE2   1 
ATOM   5365 N N     . CYS   A 1 884  ? 168.747 162.462 129.475 1.00 28.05  ?  884  CYS   C N     1 
ATOM   5366 C CA    . CYS   A 1 884  ? 167.366 162.055 129.707 1.00 23.83  ?  884  CYS   C CA    1 
ATOM   5367 C C     . CYS   A 1 884  ? 167.009 162.239 131.175 1.00 23.77  ?  884  CYS   C C     1 
ATOM   5368 O O     . CYS   A 1 884  ? 167.824 161.965 132.054 1.00 26.77  ?  884  CYS   C O     1 
ATOM   5369 C CB    . CYS   A 1 884  ? 167.146 160.603 129.293 1.00 23.97  ?  884  CYS   C CB    1 
ATOM   5370 S SG    . CYS   A 1 884  ? 165.436 160.041 129.453 1.00 25.16  ?  884  CYS   C SG    1 
ATOM   5371 N N     . ASN   A 1 885  ? 165.798 162.720 131.439 1.00 21.40  ?  885  ASN   C N     1 
ATOM   5372 C CA    . ASN   A 1 885  ? 165.363 163.021 132.799 1.00 18.86  ?  885  ASN   C CA    1 
ATOM   5373 C C     . ASN   A 1 885  ? 164.609 161.874 133.461 1.00 15.77  ?  885  ASN   C C     1 
ATOM   5374 O O     . ASN   A 1 885  ? 164.086 162.028 134.560 1.00 16.01  ?  885  ASN   C O     1 
ATOM   5375 C CB    . ASN   A 1 885  ? 164.485 164.259 132.794 1.00 21.52  ?  885  ASN   C CB    1 
ATOM   5376 C CG    . ASN   A 1 885  ? 165.232 165.499 132.439 1.00 26.35  ?  885  ASN   C CG    1 
ATOM   5377 O OD1   . ASN   A 1 885  ? 166.187 165.872 133.128 1.00 28.30  ?  885  ASN   C OD1   1 
ATOM   5378 N ND2   . ASN   A 1 885  ? 164.826 166.156 131.377 1.00 27.00  ?  885  ASN   C ND2   1 
ATOM   5379 N N     . LEU   A 1 886  ? 164.544 160.731 132.800 1.00 14.85  ?  886  LEU   C N     1 
ATOM   5380 C CA    . LEU   A 1 886  ? 163.807 159.597 133.341 1.00 11.15  ?  886  LEU   C CA    1 
ATOM   5381 C C     . LEU   A 1 886  ? 164.417 159.113 134.646 1.00 12.42  ?  886  LEU   C C     1 
ATOM   5382 O O     . LEU   A 1 886  ? 165.609 158.828 134.709 1.00 17.22  ?  886  LEU   C O     1 
ATOM   5383 C CB    . LEU   A 1 886  ? 163.800 158.460 132.317 1.00 11.69  ?  886  LEU   C CB    1 
ATOM   5384 C CG    . LEU   A 1 886  ? 163.041 157.182 132.695 1.00 10.55  ?  886  LEU   C CG    1 
ATOM   5385 C CD1   . LEU   A 1 886  ? 161.548 157.466 132.794 1.00 7.84   ?  886  LEU   C CD1   1 
ATOM   5386 C CD2   . LEU   A 1 886  ? 163.320 156.128 131.637 1.00 13.70  ?  886  LEU   C CD2   1 
ATOM   5387 N N     . GLN   A 1 887  ? 163.587 159.012 135.685 1.00 12.81  ?  887  GLN   C N     1 
ATOM   5388 C CA    . GLN   A 1 887  ? 164.032 158.573 137.003 1.00 10.59  ?  887  GLN   C CA    1 
ATOM   5389 C C     . GLN   A 1 887  ? 163.454 157.224 137.397 1.00 10.23  ?  887  GLN   C C     1 
ATOM   5390 O O     . GLN   A 1 887  ? 164.147 156.406 138.005 1.00 12.04  ?  887  GLN   C O     1 
ATOM   5391 C CB    . GLN   A 1 887  ? 163.673 159.608 138.068 1.00 11.82  ?  887  GLN   C CB    1 
ATOM   5392 C CG    . GLN   A 1 887  ? 164.409 160.925 137.927 1.00 13.42  ?  887  GLN   C CG    1 
ATOM   5393 C CD    . GLN   A 1 887  ? 164.007 161.930 138.985 1.00 18.59  ?  887  GLN   C CD    1 
ATOM   5394 O OE1   . GLN   A 1 887  ? 162.939 161.814 139.590 1.00 19.94  ?  887  GLN   C OE1   1 
ATOM   5395 N NE2   . GLN   A 1 887  ? 164.858 162.924 139.219 1.00 21.45  ?  887  GLN   C NE2   1 
ATOM   5396 N N     . LYS   A 1 888  ? 162.194 156.983 137.053 1.00 8.50   ?  888  LYS   C N     1 
ATOM   5397 C CA    . LYS   A 1 888  ? 161.571 155.712 137.395 1.00 5.75   ?  888  LYS   C CA    1 
ATOM   5398 C C     . LYS   A 1 888  ? 160.955 155.077 136.167 1.00 5.46   ?  888  LYS   C C     1 
ATOM   5399 O O     . LYS   A 1 888  ? 160.174 155.712 135.459 1.00 9.36   ?  888  LYS   C O     1 
ATOM   5400 C CB    . LYS   A 1 888  ? 160.486 155.888 138.446 1.00 8.39   ?  888  LYS   C CB    1 
ATOM   5401 C CG    . LYS   A 1 888  ? 160.923 156.582 139.718 1.00 9.40   ?  888  LYS   C CG    1 
ATOM   5402 C CD    . LYS   A 1 888  ? 159.883 156.410 140.802 1.00 9.94   ?  888  LYS   C CD    1 
ATOM   5403 C CE    . LYS   A 1 888  ? 160.297 157.095 142.080 1.00 11.70  ?  888  LYS   C CE    1 
ATOM   5404 N NZ    . LYS   A 1 888  ? 159.307 156.877 143.161 1.00 17.97  1  888  LYS   C NZ    1 
ATOM   5405 N N     . LEU   A 1 889  ? 161.293 153.823 135.917 1.00 6.42   ?  889  LEU   C N     1 
ATOM   5406 C CA    . LEU   A 1 889  ? 160.782 153.144 134.739 1.00 5.89   ?  889  LEU   C CA    1 
ATOM   5407 C C     . LEU   A 1 889  ? 160.000 151.881 135.082 1.00 5.27   ?  889  LEU   C C     1 
ATOM   5408 O O     . LEU   A 1 889  ? 160.549 150.913 135.612 1.00 9.15   ?  889  LEU   C O     1 
ATOM   5409 C CB    . LEU   A 1 889  ? 161.952 152.833 133.813 1.00 8.36   ?  889  LEU   C CB    1 
ATOM   5410 C CG    . LEU   A 1 889  ? 161.640 152.078 132.549 1.00 7.30   ?  889  LEU   C CG    1 
ATOM   5411 C CD1   . LEU   A 1 889  ? 160.653 152.871 131.684 1.00 6.24   ?  889  LEU   C CD1   1 
ATOM   5412 C CD2   . LEU   A 1 889  ? 162.936 151.853 131.806 1.00 12.09  ?  889  LEU   C CD2   1 
ATOM   5413 N N     . GLY   A 1 890  ? 158.710 151.903 134.772 1.00 5.67   ?  890  GLY   C N     1 
ATOM   5414 C CA    . GLY   A 1 890  ? 157.792 150.815 135.095 1.00 5.95   ?  890  GLY   C CA    1 
ATOM   5415 C C     . GLY   A 1 890  ? 157.573 149.819 133.964 1.00 6.71   ?  890  GLY   C C     1 
ATOM   5416 O O     . GLY   A 1 890  ? 156.440 149.645 133.497 1.00 9.56   ?  890  GLY   C O     1 
ATOM   5417 N N     . LEU   A 1 891  ? 158.617 149.138 133.531 1.00 7.91   ?  891  LEU   C N     1 
ATOM   5418 C CA    . LEU   A 1 891  ? 158.486 148.079 132.534 1.00 8.05   ?  891  LEU   C CA    1 
ATOM   5419 C C     . LEU   A 1 891  ? 158.147 146.779 133.210 1.00 9.03   ?  891  LEU   C C     1 
ATOM   5420 O O     . LEU   A 1 891  ? 158.996 145.875 133.256 1.00 13.11  ?  891  LEU   C O     1 
ATOM   5421 C CB    . LEU   A 1 891  ? 159.773 147.892 131.736 1.00 7.89   ?  891  LEU   C CB    1 
ATOM   5422 C CG    . LEU   A 1 891  ? 160.211 149.015 130.832 1.00 7.46   ?  891  LEU   C CG    1 
ATOM   5423 C CD1   . LEU   A 1 891  ? 161.592 148.703 130.315 1.00 14.10  ?  891  LEU   C CD1   1 
ATOM   5424 C CD2   . LEU   A 1 891  ? 159.238 149.147 129.688 1.00 12.40  ?  891  LEU   C CD2   1 
ATOM   5425 N N     . VAL   A 1 892  ? 156.958 146.675 133.761 1.00 8.33   ?  892  VAL   C N     1 
ATOM   5426 C CA    . VAL   A 1 892  ? 156.622 145.564 134.635 1.00 8.85   ?  892  VAL   C CA    1 
ATOM   5427 C C     . VAL   A 1 892  ? 156.151 144.345 133.841 1.00 11.65  ?  892  VAL   C C     1 
ATOM   5428 O O     . VAL   A 1 892  ? 156.944 143.634 133.247 1.00 14.42  ?  892  VAL   C O     1 
ATOM   5429 C CB    . VAL   A 1 892  ? 155.585 146.031 135.674 1.00 8.62   ?  892  VAL   C CB    1 
ATOM   5430 C CG1   . VAL   A 1 892  ? 155.188 144.925 136.631 1.00 10.01  ?  892  VAL   C CG1   1 
ATOM   5431 C CG2   . VAL   A 1 892  ? 156.179 147.183 136.457 1.00 12.62  ?  892  VAL   C CG2   1 
ATOM   5432 N N     . ASN   A 1 893  ? 154.843 144.119 133.777 1.00 10.96  ?  893  ASN   C N     1 
ATOM   5433 C CA    . ASN   A 1 893  ? 154.369 142.914 133.105 1.00 10.28  ?  893  ASN   C CA    1 
ATOM   5434 C C     . ASN   A 1 893  ? 154.274 143.116 131.607 1.00 12.17  ?  893  ASN   C C     1 
ATOM   5435 O O     . ASN   A 1 893  ? 153.192 143.114 131.036 1.00 14.54  ?  893  ASN   C O     1 
ATOM   5436 C CB    . ASN   A 1 893  ? 153.026 142.509 133.666 1.00 12.65  ?  893  ASN   C CB    1 
ATOM   5437 C CG    . ASN   A 1 893  ? 152.564 141.185 133.184 1.00 14.12  ?  893  ASN   C CG    1 
ATOM   5438 O OD1   . ASN   A 1 893  ? 153.353 140.385 132.673 1.00 20.61  ?  893  ASN   C OD1   1 
ATOM   5439 N ND2   . ASN   A 1 893  ? 151.288 140.932 133.329 1.00 17.85  ?  893  ASN   C ND2   1 
ATOM   5440 N N     . SER   A 1 894  ? 155.425 143.307 130.982 1.00 14.38  ?  894  SER   C N     1 
ATOM   5441 C CA    . SER   A 1 894  ? 155.472 143.643 129.565 1.00 11.97  ?  894  SER   C CA    1 
ATOM   5442 C C     . SER   A 1 894  ? 156.013 142.527 128.677 1.00 15.39  ?  894  SER   C C     1 
ATOM   5443 O O     . SER   A 1 894  ? 156.188 142.716 127.475 1.00 15.99  ?  894  SER   C O     1 
ATOM   5444 C CB    . SER   A 1 894  ? 156.266 144.917 129.386 1.00 12.61  ?  894  SER   C CB    1 
ATOM   5445 O OG    . SER   A 1 894  ? 155.573 146.007 129.921 1.00 12.96  ?  894  SER   C OG    1 
ATOM   5446 N N     . GLY   A 1 895  ? 156.257 141.357 129.254 1.00 20.87  ?  895  GLY   C N     1 
ATOM   5447 C CA    . GLY   A 1 895  ? 156.712 140.218 128.464 1.00 20.32  ?  895  GLY   C CA    1 
ATOM   5448 C C     . GLY   A 1 895  ? 158.164 140.334 128.022 1.00 18.98  ?  895  GLY   C C     1 
ATOM   5449 O O     . GLY   A 1 895  ? 158.519 139.901 126.927 1.00 23.18  ?  895  GLY   C O     1 
ATOM   5450 N N     . LEU   A 1 896  ? 159.003 140.920 128.863 1.00 17.42  ?  896  LEU   C N     1 
ATOM   5451 C CA    . LEU   A 1 896  ? 160.408 141.068 128.521 1.00 19.30  ?  896  LEU   C CA    1 
ATOM   5452 C C     . LEU   A 1 896  ? 161.145 139.766 128.732 1.00 22.85  ?  896  LEU   C C     1 
ATOM   5453 O O     . LEU   A 1 896  ? 160.834 139.007 129.653 1.00 23.23  ?  896  LEU   C O     1 
ATOM   5454 C CB    . LEU   A 1 896  ? 161.077 142.128 129.396 1.00 18.93  ?  896  LEU   C CB    1 
ATOM   5455 C CG    . LEU   A 1 896  ? 160.953 143.561 128.967 1.00 15.77  ?  896  LEU   C CG    1 
ATOM   5456 C CD1   . LEU   A 1 896  ? 159.503 143.925 128.833 1.00 18.88  ?  896  LEU   C CD1   1 
ATOM   5457 C CD2   . LEU   A 1 896  ? 161.632 144.431 130.020 1.00 15.47  ?  896  LEU   C CD2   1 
ATOM   5458 N N     . THR   A 1 897  ? 162.161 139.534 127.914 1.00 24.15  ?  897  THR   C N     1 
ATOM   5459 C CA    . THR   A 1 897  ? 163.043 138.395 128.115 1.00 24.40  ?  897  THR   C CA    1 
ATOM   5460 C C     . THR   A 1 897  ? 164.478 138.872 128.213 1.00 26.16  ?  897  THR   C C     1 
ATOM   5461 O O     . THR   A 1 897  ? 164.753 140.071 128.130 1.00 27.66  ?  897  THR   C O     1 
ATOM   5462 C CB    . THR   A 1 897  ? 162.932 137.357 126.988 1.00 26.88  ?  897  THR   C CB    1 
ATOM   5463 O OG1   . THR   A 1 897  ? 163.581 137.849 125.813 1.00 30.14  ?  897  THR   C OG1   1 
ATOM   5464 C CG2   . THR   A 1 897  ? 161.475 137.059 126.681 1.00 27.63  ?  897  THR   C CG2   1 
ATOM   5465 N N     . SER   A 1 898  ? 165.398 137.932 128.373 1.00 28.25  ?  898  SER   C N     1 
ATOM   5466 C CA    . SER   A 1 898  ? 166.811 138.249 128.518 1.00 29.62  ?  898  SER   C CA    1 
ATOM   5467 C C     . SER   A 1 898  ? 167.354 138.992 127.306 1.00 31.13  ?  898  SER   C C     1 
ATOM   5468 O O     . SER   A 1 898  ? 168.376 139.668 127.387 1.00 32.33  ?  898  SER   C O     1 
ATOM   5469 C CB    . SER   A 1 898  ? 167.600 136.976 128.726 1.00 32.12  ?  898  SER   C CB    1 
ATOM   5470 O OG    . SER   A 1 898  ? 167.568 136.174 127.580 1.00 34.14  ?  898  SER   C OG    1 
ATOM   5471 N N     . VAL   A 1 899  ? 166.651 138.899 126.186 1.00 28.92  ?  899  VAL   C N     1 
ATOM   5472 C CA    . VAL   A 1 899  ? 167.086 139.547 124.960 1.00 26.81  ?  899  VAL   C CA    1 
ATOM   5473 C C     . VAL   A 1 899  ? 167.207 141.054 125.133 1.00 29.17  ?  899  VAL   C C     1 
ATOM   5474 O O     . VAL   A 1 899  ? 168.093 141.680 124.553 1.00 30.82  ?  899  VAL   C O     1 
ATOM   5475 C CB    . VAL   A 1 899  ? 166.109 139.237 123.815 1.00 27.28  ?  899  VAL   C CB    1 
ATOM   5476 C CG1   . VAL   A 1 899  ? 166.446 140.075 122.587 1.00 29.37  ?  899  VAL   C CG1   1 
ATOM   5477 C CG2   . VAL   A 1 899  ? 166.179 137.762 123.487 1.00 32.87  ?  899  VAL   C CG2   1 
ATOM   5478 N N     . CYS   A 1 900  ? 166.294 141.647 125.895 1.00 31.28  ?  900  CYS   C N     1 
ATOM   5479 C CA    . CYS   A 1 900  ? 166.263 143.095 126.062 1.00 30.23  ?  900  CYS   C CA    1 
ATOM   5480 C C     . CYS   A 1 900  ? 167.130 143.578 127.212 1.00 29.99  ?  900  CYS   C C     1 
ATOM   5481 O O     . CYS   A 1 900  ? 167.223 144.782 127.453 1.00 28.92  ?  900  CYS   C O     1 
ATOM   5482 C CB    . CYS   A 1 900  ? 164.854 143.571 126.353 1.00 25.76  ?  900  CYS   C CB    1 
ATOM   5483 S SG    . CYS   A 1 900  ? 164.318 143.150 128.008 1.00 30.58  ?  900  CYS   C SG    1 
ATOM   5484 N N     . CYS   A 1 901  ? 167.718 142.656 127.964 1.00 28.61  ?  901  CYS   C N     1 
ATOM   5485 C CA    . CYS   A 1 901  ? 168.453 143.066 129.146 1.00 27.12  ?  901  CYS   C CA    1 
ATOM   5486 C C     . CYS   A 1 901  ? 169.731 143.793 128.789 1.00 28.44  ?  901  CYS   C C     1 
ATOM   5487 O O     . CYS   A 1 901  ? 170.218 144.605 129.575 1.00 28.75  ?  901  CYS   C O     1 
ATOM   5488 C CB    . CYS   A 1 901  ? 168.749 141.881 130.043 1.00 29.49  ?  901  CYS   C CB    1 
ATOM   5489 S SG    . CYS   A 1 901  ? 167.284 141.247 130.864 1.00 32.50  ?  901  CYS   C SG    1 
ATOM   5490 N N     . SER   A 1 902  ? 170.261 143.539 127.598 1.00 29.01  ?  902  SER   C N     1 
ATOM   5491 C CA    . SER   A 1 902  ? 171.444 144.253 127.161 1.00 27.73  ?  902  SER   C CA    1 
ATOM   5492 C C     . SER   A 1 902  ? 171.103 145.716 126.899 1.00 29.41  ?  902  SER   C C     1 
ATOM   5493 O O     . SER   A 1 902  ? 171.939 146.603 127.084 1.00 30.77  ?  902  SER   C O     1 
ATOM   5494 C CB    . SER   A 1 902  ? 171.998 143.616 125.908 1.00 32.16  ?  902  SER   C CB    1 
ATOM   5495 O OG    . SER   A 1 902  ? 171.119 143.786 124.832 1.00 32.05  ?  902  SER   C OG    1 
ATOM   5496 N N     . ALA   A 1 903  ? 169.857 145.972 126.500 1.00 28.90  ?  903  ALA   C N     1 
ATOM   5497 C CA    . ALA   A 1 903  ? 169.402 147.332 126.263 1.00 28.47  ?  903  ALA   C CA    1 
ATOM   5498 C C     . ALA   A 1 903  ? 169.213 148.051 127.587 1.00 27.86  ?  903  ALA   C C     1 
ATOM   5499 O O     . ALA   A 1 903  ? 169.605 149.209 127.740 1.00 29.52  ?  903  ALA   C O     1 
ATOM   5500 C CB    . ALA   A 1 903  ? 168.106 147.329 125.470 1.00 26.85  ?  903  ALA   C CB    1 
ATOM   5501 N N     . LEU   A 1 904  ? 168.645 147.343 128.556 1.00 25.79  ?  904  LEU   C N     1 
ATOM   5502 C CA    . LEU   A 1 904  ? 168.440 147.912 129.876 1.00 24.12  ?  904  LEU   C CA    1 
ATOM   5503 C C     . LEU   A 1 904  ? 169.780 148.178 130.537 1.00 27.78  ?  904  LEU   C C     1 
ATOM   5504 O O     . LEU   A 1 904  ? 169.954 149.188 131.220 1.00 28.33  ?  904  LEU   C O     1 
ATOM   5505 C CB    . LEU   A 1 904  ? 167.598 146.964 130.734 1.00 24.42  ?  904  LEU   C CB    1 
ATOM   5506 C CG    . LEU   A 1 904  ? 166.123 146.805 130.313 1.00 22.87  ?  904  LEU   C CG    1 
ATOM   5507 C CD1   . LEU   A 1 904  ? 165.501 145.645 131.070 1.00 22.62  ?  904  LEU   C CD1   1 
ATOM   5508 C CD2   . LEU   A 1 904  ? 165.365 148.085 130.614 1.00 19.76  ?  904  LEU   C CD2   1 
ATOM   5509 N N     . SER   A 1 905  ? 170.735 147.282 130.310 1.00 28.51  ?  905  SER   C N     1 
ATOM   5510 C CA    . SER   A 1 905  ? 172.072 147.430 130.855 1.00 28.25  ?  905  SER   C CA    1 
ATOM   5511 C C     . SER   A 1 905  ? 172.720 148.703 130.342 1.00 29.70  ?  905  SER   C C     1 
ATOM   5512 O O     . SER   A 1 905  ? 173.293 149.473 131.114 1.00 30.87  ?  905  SER   C O     1 
ATOM   5513 C CB    . SER   A 1 905  ? 172.920 146.240 130.484 1.00 32.17  ?  905  SER   C CB    1 
ATOM   5514 O OG    . SER   A 1 905  ? 174.221 146.390 130.963 1.00 37.13  ?  905  SER   C OG    1 
ATOM   5515 N N     . SER   A 1 906  ? 172.596 148.945 129.041 1.00 29.71  ?  906  SER   C N     1 
ATOM   5516 C CA    . SER   A 1 906  ? 173.157 150.146 128.445 1.00 29.73  ?  906  SER   C CA    1 
ATOM   5517 C C     . SER   A 1 906  ? 172.586 151.388 129.114 1.00 31.27  ?  906  SER   C C     1 
ATOM   5518 O O     . SER   A 1 906  ? 173.319 152.328 129.433 1.00 31.96  ?  906  SER   C O     1 
ATOM   5519 C CB    . SER   A 1 906  ? 172.862 150.173 126.962 1.00 33.63  ?  906  SER   C CB    1 
ATOM   5520 O OG    . SER   A 1 906  ? 173.410 151.309 126.359 1.00 39.39  ?  906  SER   C OG    1 
ATOM   5521 N N     . VAL   A 1 907  ? 171.278 151.381 129.358 1.00 29.45  ?  907  VAL   C N     1 
ATOM   5522 C CA    . VAL   A 1 907  ? 170.645 152.523 130.000 1.00 28.22  ?  907  VAL   C CA    1 
ATOM   5523 C C     . VAL   A 1 907  ? 171.187 152.722 131.405 1.00 27.16  ?  907  VAL   C C     1 
ATOM   5524 O O     . VAL   A 1 907  ? 171.530 153.837 131.790 1.00 28.34  ?  907  VAL   C O     1 
ATOM   5525 C CB    . VAL   A 1 907  ? 169.115 152.346 130.072 1.00 25.13  ?  907  VAL   C CB    1 
ATOM   5526 C CG1   . VAL   A 1 907  ? 168.497 153.474 130.899 1.00 24.66  ?  907  VAL   C CG1   1 
ATOM   5527 C CG2   . VAL   A 1 907  ? 168.534 152.340 128.676 1.00 30.45  ?  907  VAL   C CG2   1 
ATOM   5528 N N     . LEU   A 1 908  ? 171.298 151.639 132.164 1.00 26.51  ?  908  LEU   C N     1 
ATOM   5529 C CA    . LEU   A 1 908  ? 171.791 151.725 133.532 1.00 26.05  ?  908  LEU   C CA    1 
ATOM   5530 C C     . LEU   A 1 908  ? 173.210 152.272 133.594 1.00 29.01  ?  908  LEU   C C     1 
ATOM   5531 O O     . LEU   A 1 908  ? 173.535 153.071 134.473 1.00 29.51  ?  908  LEU   C O     1 
ATOM   5532 C CB    . LEU   A 1 908  ? 171.760 150.336 134.174 1.00 24.70  ?  908  LEU   C CB    1 
ATOM   5533 C CG    . LEU   A 1 908  ? 170.380 149.766 134.487 1.00 22.12  ?  908  LEU   C CG    1 
ATOM   5534 C CD1   . LEU   A 1 908  ? 170.513 148.286 134.775 1.00 27.91  ?  908  LEU   C CD1   1 
ATOM   5535 C CD2   . LEU   A 1 908  ? 169.804 150.480 135.690 1.00 20.12  ?  908  LEU   C CD2   1 
ATOM   5536 N N     . SER   A 1 909  ? 174.044 151.861 132.645 1.00 30.21  ?  909  SER   C N     1 
ATOM   5537 C CA    . SER   A 1 909  ? 175.434 152.296 132.597 1.00 32.28  ?  909  SER   C CA    1 
ATOM   5538 C C     . SER   A 1 909  ? 175.592 153.779 132.273 1.00 31.47  ?  909  SER   C C     1 
ATOM   5539 O O     . SER   A 1 909  ? 176.513 154.427 132.771 1.00 35.42  ?  909  SER   C O     1 
ATOM   5540 C CB    . SER   A 1 909  ? 176.191 151.494 131.556 1.00 34.21  ?  909  SER   C CB    1 
ATOM   5541 O OG    . SER   A 1 909  ? 176.298 150.147 131.925 1.00 36.86  ?  909  SER   C OG    1 
ATOM   5542 N N     . THR   A 1 910  ? 174.720 154.314 131.420 1.00 30.95  ?  910  THR   C N     1 
ATOM   5543 C CA    . THR   A 1 910  ? 174.889 155.690 130.955 1.00 30.66  ?  910  THR   C CA    1 
ATOM   5544 C C     . THR   A 1 910  ? 173.973 156.713 131.628 1.00 30.98  ?  910  THR   C C     1 
ATOM   5545 O O     . THR   A 1 910  ? 174.398 157.833 131.915 1.00 31.55  ?  910  THR   C O     1 
ATOM   5546 C CB    . THR   A 1 910  ? 174.674 155.772 129.433 1.00 33.69  ?  910  THR   C CB    1 
ATOM   5547 O OG1   . THR   A 1 910  ? 175.614 154.918 128.773 1.00 36.10  ?  910  THR   C OG1   1 
ATOM   5548 C CG2   . THR   A 1 910  ? 174.868 157.201 128.948 1.00 37.18  ?  910  THR   C CG2   1 
ATOM   5549 N N     . ASN   A 1 911  ? 172.716 156.354 131.856 1.00 29.50  ?  911  ASN   C N     1 
ATOM   5550 C CA    . ASN   A 1 911  ? 171.753 157.303 132.399 1.00 28.07  ?  911  ASN   C CA    1 
ATOM   5551 C C     . ASN   A 1 911  ? 171.821 157.341 133.920 1.00 25.04  ?  911  ASN   C C     1 
ATOM   5552 O O     . ASN   A 1 911  ? 171.312 156.452 134.604 1.00 25.28  ?  911  ASN   C O     1 
ATOM   5553 C CB    . ASN   A 1 911  ? 170.352 156.971 131.926 1.00 26.00  ?  911  ASN   C CB    1 
ATOM   5554 C CG    . ASN   A 1 911  ? 169.334 157.967 132.392 1.00 24.90  ?  911  ASN   C CG    1 
ATOM   5555 O OD1   . ASN   A 1 911  ? 169.531 158.658 133.397 1.00 25.50  ?  911  ASN   C OD1   1 
ATOM   5556 N ND2   . ASN   A 1 911  ? 168.243 158.062 131.687 1.00 25.15  ?  911  ASN   C ND2   1 
ATOM   5557 N N     . GLN   A 1 912  ? 172.443 158.386 134.448 1.00 24.70  ?  912  GLN   C N     1 
ATOM   5558 C CA    . GLN   A 1 912  ? 172.693 158.487 135.877 1.00 26.21  ?  912  GLN   C CA    1 
ATOM   5559 C C     . GLN   A 1 912  ? 171.488 159.010 136.631 1.00 24.20  ?  912  GLN   C C     1 
ATOM   5560 O O     . GLN   A 1 912  ? 171.527 159.152 137.852 1.00 25.87  ?  912  GLN   C O     1 
ATOM   5561 C CB    . GLN   A 1 912  ? 173.892 159.393 136.147 1.00 28.80  ?  912  GLN   C CB    1 
ATOM   5562 C CG    . GLN   A 1 912  ? 175.207 158.847 135.644 1.00 32.06  ?  912  GLN   C CG    1 
ATOM   5563 C CD    . GLN   A 1 912  ? 176.368 159.743 136.004 1.00 39.91  ?  912  GLN   C CD    1 
ATOM   5564 O OE1   . GLN   A 1 912  ? 176.209 160.733 136.728 1.00 33.83  ?  912  GLN   C OE1   1 
ATOM   5565 N NE2   . GLN   A 1 912  ? 177.548 159.406 135.501 1.00 44.21  ?  912  GLN   C NE2   1 
ATOM   5566 N N     . ASN   A 1 913  ? 170.424 159.315 135.908 1.00 23.12  ?  913  ASN   C N     1 
ATOM   5567 C CA    . ASN   A 1 913  ? 169.229 159.839 136.538 1.00 20.17  ?  913  ASN   C CA    1 
ATOM   5568 C C     . ASN   A 1 913  ? 168.232 158.742 136.855 1.00 16.55  ?  913  ASN   C C     1 
ATOM   5569 O O     . ASN   A 1 913  ? 167.218 159.002 137.494 1.00 18.43  ?  913  ASN   C O     1 
ATOM   5570 C CB    . ASN   A 1 913  ? 168.577 160.882 135.655 1.00 20.34  ?  913  ASN   C CB    1 
ATOM   5571 C CG    . ASN   A 1 913  ? 169.424 162.091 135.475 1.00 25.05  ?  913  ASN   C CG    1 
ATOM   5572 O OD1   . ASN   A 1 913  ? 170.165 162.499 136.377 1.00 27.84  ?  913  ASN   C OD1   1 
ATOM   5573 N ND2   . ASN   A 1 913  ? 169.335 162.685 134.315 1.00 27.50  ?  913  ASN   C ND2   1 
ATOM   5574 N N     . LEU   A 1 914  ? 168.508 157.516 136.419 1.00 16.25  ?  914  LEU   C N     1 
ATOM   5575 C CA    . LEU   A 1 914  ? 167.551 156.439 136.628 1.00 12.87  ?  914  LEU   C CA    1 
ATOM   5576 C C     . LEU   A 1 914  ? 167.786 155.810 137.985 1.00 15.09  ?  914  LEU   C C     1 
ATOM   5577 O O     . LEU   A 1 914  ? 168.859 155.271 138.249 1.00 17.87  ?  914  LEU   C O     1 
ATOM   5578 C CB    . LEU   A 1 914  ? 167.679 155.386 135.517 1.00 13.79  ?  914  LEU   C CB    1 
ATOM   5579 C CG    . LEU   A 1 914  ? 166.732 154.152 135.603 1.00 12.24  ?  914  LEU   C CG    1 
ATOM   5580 C CD1   . LEU   A 1 914  ? 165.284 154.585 135.425 1.00 11.74  ?  914  LEU   C CD1   1 
ATOM   5581 C CD2   . LEU   A 1 914  ? 167.117 153.151 134.529 1.00 16.65  ?  914  LEU   C CD2   1 
ATOM   5582 N N     . THR   A 1 915  ? 166.794 155.913 138.864 1.00 13.98  ?  915  THR   C N     1 
ATOM   5583 C CA    . THR   A 1 915  ? 166.958 155.437 140.227 1.00 11.98  ?  915  THR   C CA    1 
ATOM   5584 C C     . THR   A 1 915  ? 166.061 154.261 140.575 1.00 11.83  ?  915  THR   C C     1 
ATOM   5585 O O     . THR   A 1 915  ? 166.375 153.507 141.496 1.00 14.77  ?  915  THR   C O     1 
ATOM   5586 C CB    . THR   A 1 915  ? 166.731 156.576 141.234 1.00 14.30  ?  915  THR   C CB    1 
ATOM   5587 O OG1   . THR   A 1 915  ? 165.415 157.117 141.069 1.00 14.90  ?  915  THR   C OG1   1 
ATOM   5588 C CG2   . THR   A 1 915  ? 167.761 157.667 141.015 1.00 15.52  ?  915  THR   C CG2   1 
ATOM   5589 N N     . HIS   A 1 916  ? 164.973 154.078 139.837 1.00 11.22  ?  916  HIS   C N     1 
ATOM   5590 C CA    . HIS   A 1 916  ? 164.050 152.987 140.132 1.00 9.22   ?  916  HIS   C CA    1 
ATOM   5591 C C     . HIS   A 1 916  ? 163.671 152.218 138.880 1.00 8.89   ?  916  HIS   C C     1 
ATOM   5592 O O     . HIS   A 1 916  ? 163.207 152.800 137.900 1.00 11.26  ?  916  HIS   C O     1 
ATOM   5593 C CB    . HIS   A 1 916  ? 162.769 153.514 140.777 1.00 9.89   ?  916  HIS   C CB    1 
ATOM   5594 C CG    . HIS   A 1 916  ? 162.953 154.200 142.093 1.00 10.65  ?  916  HIS   C CG    1 
ATOM   5595 N ND1   . HIS   A 1 916  ? 163.593 155.415 142.227 1.00 12.09  ?  916  HIS   C ND1   1 
ATOM   5596 C CD2   . HIS   A 1 916  ? 162.554 153.852 143.328 1.00 10.91  ?  916  HIS   C CD2   1 
ATOM   5597 C CE1   . HIS   A 1 916  ? 163.600 155.765 143.499 1.00 11.63  ?  916  HIS   C CE1   1 
ATOM   5598 N NE2   . HIS   A 1 916  ? 162.972 154.836 144.185 1.00 13.70  ?  916  HIS   C NE2   1 
ATOM   5599 N N     . LEU   A 1 917  ? 163.846 150.906 138.922 1.00 9.26   ?  917  LEU   C N     1 
ATOM   5600 C CA    . LEU   A 1 917  ? 163.496 150.066 137.787 1.00 8.20   ?  917  LEU   C CA    1 
ATOM   5601 C C     . LEU   A 1 917  ? 162.633 148.894 138.238 1.00 8.05   ?  917  LEU   C C     1 
ATOM   5602 O O     . LEU   A 1 917  ? 163.036 148.113 139.101 1.00 12.73  ?  917  LEU   C O     1 
ATOM   5603 C CB    . LEU   A 1 917  ? 164.784 149.582 137.104 1.00 12.70  ?  917  LEU   C CB    1 
ATOM   5604 C CG    . LEU   A 1 917  ? 164.637 148.655 135.901 1.00 10.89  ?  917  LEU   C CG    1 
ATOM   5605 C CD1   . LEU   A 1 917  ? 163.917 149.378 134.768 1.00 11.63  ?  917  LEU   C CD1   1 
ATOM   5606 C CD2   . LEU   A 1 917  ? 166.022 148.215 135.455 1.00 14.07  ?  917  LEU   C CD2   1 
ATOM   5607 N N     . TYR   A 1 918  ? 161.437 148.787 137.669 1.00 8.03   ?  918  TYR   C N     1 
ATOM   5608 C CA    . TYR   A 1 918  ? 160.497 147.748 138.076 1.00 9.14   ?  918  TYR   C CA    1 
ATOM   5609 C C     . TYR   A 1 918  ? 160.272 146.746 136.958 1.00 9.59   ?  918  TYR   C C     1 
ATOM   5610 O O     . TYR   A 1 918  ? 159.623 147.064 135.966 1.00 10.94  ?  918  TYR   C O     1 
ATOM   5611 C CB    . TYR   A 1 918  ? 159.160 148.374 138.473 1.00 10.92  ?  918  TYR   C CB    1 
ATOM   5612 C CG    . TYR   A 1 918  ? 159.270 149.427 139.544 1.00 11.81  ?  918  TYR   C CG    1 
ATOM   5613 C CD1   . TYR   A 1 918  ? 159.436 150.748 139.185 1.00 10.94  ?  918  TYR   C CD1   1 
ATOM   5614 C CD2   . TYR   A 1 918  ? 159.208 149.080 140.873 1.00 14.83  ?  918  TYR   C CD2   1 
ATOM   5615 C CE1   . TYR   A 1 918  ? 159.543 151.715 140.152 1.00 11.47  ?  918  TYR   C CE1   1 
ATOM   5616 C CE2   . TYR   A 1 918  ? 159.317 150.047 141.842 1.00 13.48  ?  918  TYR   C CE2   1 
ATOM   5617 C CZ    . TYR   A 1 918  ? 159.483 151.359 141.485 1.00 12.73  ?  918  TYR   C CZ    1 
ATOM   5618 O OH    . TYR   A 1 918  ? 159.592 152.323 142.455 1.00 17.52  ?  918  TYR   C OH    1 
ATOM   5619 N N     . LEU   A 1 919  ? 160.828 145.545 137.100 1.00 11.01  ?  919  LEU   C N     1 
ATOM   5620 C CA    . LEU   A 1 919  ? 160.741 144.544 136.041 1.00 10.66  ?  919  LEU   C CA    1 
ATOM   5621 C C     . LEU   A 1 919  ? 159.906 143.321 136.411 1.00 11.48  ?  919  LEU   C C     1 
ATOM   5622 O O     . LEU   A 1 919  ? 159.944 142.305 135.714 1.00 16.00  ?  919  LEU   C O     1 
ATOM   5623 C CB    . LEU   A 1 919  ? 162.149 144.083 135.659 1.00 12.95  ?  919  LEU   C CB    1 
ATOM   5624 C CG    . LEU   A 1 919  ? 163.084 145.169 135.138 1.00 10.41  ?  919  LEU   C CG    1 
ATOM   5625 C CD1   . LEU   A 1 919  ? 164.463 144.588 134.951 1.00 14.03  ?  919  LEU   C CD1   1 
ATOM   5626 C CD2   . LEU   A 1 919  ? 162.557 145.722 133.825 1.00 13.24  ?  919  LEU   C CD2   1 
ATOM   5627 N N     . ARG   A 1 920  ? 159.172 143.385 137.506 1.00 11.57  ?  920  ARG   C N     1 
ATOM   5628 C CA    . ARG   A 1 920  ? 158.489 142.182 137.949 1.00 13.18  ?  920  ARG   C CA    1 
ATOM   5629 C C     . ARG   A 1 920  ? 157.435 141.704 136.969 1.00 12.99  ?  920  ARG   C C     1 
ATOM   5630 O O     . ARG   A 1 920  ? 156.787 142.495 136.295 1.00 15.52  ?  920  ARG   C O     1 
ATOM   5631 C CB    . ARG   A 1 920  ? 157.849 142.369 139.313 1.00 16.52  ?  920  ARG   C CB    1 
ATOM   5632 C CG    . ARG   A 1 920  ? 156.688 143.309 139.382 1.00 18.22  ?  920  ARG   C CG    1 
ATOM   5633 C CD    . ARG   A 1 920  ? 156.051 143.295 140.715 1.00 15.74  ?  920  ARG   C CD    1 
ATOM   5634 N NE    . ARG   A 1 920  ? 154.989 144.281 140.805 1.00 19.57  ?  920  ARG   C NE    1 
ATOM   5635 C CZ    . ARG   A 1 920  ? 153.715 144.086 140.407 1.00 22.96  ?  920  ARG   C CZ    1 
ATOM   5636 N NH1   . ARG   A 1 920  ? 153.347 142.933 139.892 1.00 19.59  1  920  ARG   C NH1   1 
ATOM   5637 N NH2   . ARG   A 1 920  ? 152.832 145.059 140.534 1.00 24.67  ?  920  ARG   C NH2   1 
ATOM   5638 N N     . GLY   A 1 921  ? 157.258 140.395 136.898 1.00 15.24  ?  921  GLY   C N     1 
ATOM   5639 C CA    . GLY   A 1 921  ? 156.246 139.801 136.031 1.00 13.79  ?  921  GLY   C CA    1 
ATOM   5640 C C     . GLY   A 1 921  ? 156.817 139.385 134.684 1.00 15.95  ?  921  GLY   C C     1 
ATOM   5641 O O     . GLY   A 1 921  ? 156.153 138.704 133.903 1.00 18.48  ?  921  GLY   C O     1 
ATOM   5642 N N     . ASN   A 1 922  ? 158.050 139.785 134.414 1.00 16.93  ?  922  ASN   C N     1 
ATOM   5643 C CA    . ASN   A 1 922  ? 158.717 139.434 133.170 1.00 17.66  ?  922  ASN   C CA    1 
ATOM   5644 C C     . ASN   A 1 922  ? 159.306 138.039 133.280 1.00 21.69  ?  922  ASN   C C     1 
ATOM   5645 O O     . ASN   A 1 922  ? 159.173 137.385 134.308 1.00 24.44  ?  922  ASN   C O     1 
ATOM   5646 C CB    . ASN   A 1 922  ? 159.786 140.453 132.853 1.00 18.28  ?  922  ASN   C CB    1 
ATOM   5647 C CG    . ASN   A 1 922  ? 159.212 141.779 132.471 1.00 17.37  ?  922  ASN   C CG    1 
ATOM   5648 O OD1   . ASN   A 1 922  ? 158.428 141.892 131.516 1.00 16.69  ?  922  ASN   C OD1   1 
ATOM   5649 N ND2   . ASN   A 1 922  ? 159.596 142.792 133.197 1.00 15.28  ?  922  ASN   C ND2   1 
ATOM   5650 N N     . THR   A 1 923  ? 159.938 137.568 132.216 1.00 21.92  ?  923  THR   C N     1 
ATOM   5651 C CA    . THR   A 1 923  ? 160.578 136.265 132.253 1.00 20.93  ?  923  THR   C CA    1 
ATOM   5652 C C     . THR   A 1 923  ? 162.001 136.415 131.765 1.00 22.75  ?  923  THR   C C     1 
ATOM   5653 O O     . THR   A 1 923  ? 162.307 136.140 130.610 1.00 25.32  ?  923  THR   C O     1 
ATOM   5654 C CB    . THR   A 1 923  ? 159.838 135.236 131.383 1.00 21.25  ?  923  THR   C CB    1 
ATOM   5655 O OG1   . THR   A 1 923  ? 159.734 135.730 130.050 1.00 26.32  ?  923  THR   C OG1   1 
ATOM   5656 C CG2   . THR   A 1 923  ? 158.453 134.978 131.938 1.00 23.18  ?  923  THR   C CG2   1 
ATOM   5657 N N     . LEU   A 1 924  ? 162.849 136.915 132.656 1.00 22.99  ?  924  LEU   C N     1 
ATOM   5658 C CA    . LEU   A 1 924  ? 164.201 137.290 132.270 1.00 24.90  ?  924  LEU   C CA    1 
ATOM   5659 C C     . LEU   A 1 924  ? 165.124 136.105 132.451 1.00 29.48  ?  924  LEU   C C     1 
ATOM   5660 O O     . LEU   A 1 924  ? 166.073 135.908 131.682 1.00 30.74  ?  924  LEU   C O     1 
ATOM   5661 C CB    . LEU   A 1 924  ? 164.679 138.451 133.152 1.00 26.85  ?  924  LEU   C CB    1 
ATOM   5662 C CG    . LEU   A 1 924  ? 163.786 139.709 133.173 1.00 23.74  ?  924  LEU   C CG    1 
ATOM   5663 C CD1   . LEU   A 1 924  ? 164.397 140.717 134.130 1.00 24.03  ?  924  LEU   C CD1   1 
ATOM   5664 C CD2   . LEU   A 1 924  ? 163.649 140.295 131.771 1.00 26.47  ?  924  LEU   C CD2   1 
ATOM   5665 N N     . GLY   A 1 925  ? 164.842 135.305 133.462 1.00 30.82  ?  925  GLY   C N     1 
ATOM   5666 C CA    . GLY   A 1 925  ? 165.641 134.135 133.744 1.00 33.13  ?  925  GLY   C CA    1 
ATOM   5667 C C     . GLY   A 1 925  ? 167.004 134.526 134.276 1.00 34.51  ?  925  GLY   C C     1 
ATOM   5668 O O     . GLY   A 1 925  ? 167.269 135.695 134.565 1.00 34.22  ?  925  GLY   C O     1 
ATOM   5669 N N     . ASP   A 1 926  ? 167.885 133.549 134.373 1.00 35.30  ?  926  ASP   C N     1 
ATOM   5670 C CA    . ASP   A 1 926  ? 169.191 133.780 134.952 1.00 38.93  ?  926  ASP   C CA    1 
ATOM   5671 C C     . ASP   A 1 926  ? 170.084 134.524 133.974 1.00 36.63  ?  926  ASP   C C     1 
ATOM   5672 O O     . ASP   A 1 926  ? 170.942 135.311 134.372 1.00 37.60  ?  926  ASP   C O     1 
ATOM   5673 C CB    . ASP   A 1 926  ? 169.811 132.446 135.333 1.00 47.34  ?  926  ASP   C CB    1 
ATOM   5674 C CG    . ASP   A 1 926  ? 168.982 131.712 136.376 1.00 47.71  ?  926  ASP   C CG    1 
ATOM   5675 O OD1   . ASP   A 1 926  ? 168.208 132.344 137.074 1.00 43.70  ?  926  ASP   C OD1   1 
ATOM   5676 O OD2   . ASP   A 1 926  ? 169.090 130.520 136.428 1.00 52.78  -1 926  ASP   C OD2   1 
ATOM   5677 N N     . LYS   A 1 927  ? 169.871 134.287 132.685 1.00 34.16  ?  927  LYS   C N     1 
ATOM   5678 C CA    . LYS   A 1 927  ? 170.659 134.964 131.672 1.00 34.60  ?  927  LYS   C CA    1 
ATOM   5679 C C     . LYS   A 1 927  ? 170.390 136.459 131.718 1.00 37.60  ?  927  LYS   C C     1 
ATOM   5680 O O     . LYS   A 1 927  ? 171.309 137.270 131.581 1.00 38.04  ?  927  LYS   C O     1 
ATOM   5681 C CB    . LYS   A 1 927  ? 170.363 134.402 130.286 1.00 29.81  ?  927  LYS   C CB    1 
ATOM   5682 C CG    . LYS   A 1 927  ? 171.214 135.005 129.187 1.00 41.78  ?  927  LYS   C CG    1 
ATOM   5683 C CD    . LYS   A 1 927  ? 170.997 134.299 127.858 1.00 43.33  ?  927  LYS   C CD    1 
ATOM   5684 C CE    . LYS   A 1 927  ? 171.864 134.906 126.768 1.00 40.33  ?  927  LYS   C CE    1 
ATOM   5685 N NZ    . LYS   A 1 927  ? 171.693 134.204 125.474 1.00 59.27  1  927  LYS   C NZ    1 
ATOM   5686 N N     . GLY   A 1 928  ? 169.125 136.829 131.920 1.00 35.28  ?  928  GLY   C N     1 
ATOM   5687 C CA    . GLY   A 1 928  ? 168.761 138.231 131.998 1.00 32.83  ?  928  GLY   C CA    1 
ATOM   5688 C C     . GLY   A 1 928  ? 169.451 138.911 133.167 1.00 31.58  ?  928  GLY   C C     1 
ATOM   5689 O O     . GLY   A 1 928  ? 169.930 140.038 133.040 1.00 32.40  ?  928  GLY   C O     1 
ATOM   5690 N N     . ILE   A 1 929  ? 169.540 138.216 134.296 1.00 32.80  ?  929  ILE   C N     1 
ATOM   5691 C CA    . ILE   A 1 929  ? 170.203 138.788 135.458 1.00 32.27  ?  929  ILE   C CA    1 
ATOM   5692 C C     . ILE   A 1 929  ? 171.664 139.049 135.166 1.00 34.66  ?  929  ILE   C C     1 
ATOM   5693 O O     . ILE   A 1 929  ? 172.190 140.101 135.530 1.00 35.73  ?  929  ILE   C O     1 
ATOM   5694 C CB    . ILE   A 1 929  ? 170.087 137.871 136.687 1.00 34.11  ?  929  ILE   C CB    1 
ATOM   5695 C CG1   . ILE   A 1 929  ? 168.621 137.733 137.101 1.00 35.67  ?  929  ILE   C CG1   1 
ATOM   5696 C CG2   . ILE   A 1 929  ? 170.944 138.403 137.848 1.00 37.05  ?  929  ILE   C CG2   1 
ATOM   5697 C CD1   . ILE   A 1 929  ? 167.939 139.027 137.503 1.00 31.16  ?  929  ILE   C CD1   1 
ATOM   5698 N N     . LYS   A 1 930  ? 172.323 138.105 134.508 1.00 35.03  ?  930  LYS   C N     1 
ATOM   5699 C CA    . LYS   A 1 930  ? 173.729 138.297 134.194 1.00 38.35  ?  930  LYS   C CA    1 
ATOM   5700 C C     . LYS   A 1 930  ? 173.921 139.529 133.322 1.00 37.40  ?  930  LYS   C C     1 
ATOM   5701 O O     . LYS   A 1 930  ? 174.823 140.334 133.562 1.00 38.87  ?  930  LYS   C O     1 
ATOM   5702 C CB    . LYS   A 1 930  ? 174.294 137.068 133.486 1.00 44.29  ?  930  LYS   C CB    1 
ATOM   5703 C CG    . LYS   A 1 930  ? 174.442 135.853 134.380 1.00 47.98  ?  930  LYS   C CG    1 
ATOM   5704 C CD    . LYS   A 1 930  ? 175.021 134.667 133.626 1.00 47.88  ?  930  LYS   C CD    1 
ATOM   5705 C CE    . LYS   A 1 930  ? 175.046 133.409 134.495 1.00 56.02  ?  930  LYS   C CE    1 
ATOM   5706 N NZ    . LYS   A 1 930  ? 176.007 133.521 135.639 1.00 56.34  1  930  LYS   C NZ    1 
ATOM   5707 N N     . LEU   A 1 931  ? 173.054 139.691 132.329 1.00 35.84  ?  931  LEU   C N     1 
ATOM   5708 C CA    . LEU   A 1 931  ? 173.145 140.835 131.435 1.00 35.40  ?  931  LEU   C CA    1 
ATOM   5709 C C     . LEU   A 1 931  ? 172.874 142.147 132.157 1.00 34.72  ?  931  LEU   C C     1 
ATOM   5710 O O     . LEU   A 1 931  ? 173.562 143.140 131.928 1.00 34.85  ?  931  LEU   C O     1 
ATOM   5711 C CB    . LEU   A 1 931  ? 172.156 140.668 130.281 1.00 33.58  ?  931  LEU   C CB    1 
ATOM   5712 C CG    . LEU   A 1 931  ? 172.491 139.582 129.254 1.00 34.01  ?  931  LEU   C CG    1 
ATOM   5713 C CD1   . LEU   A 1 931  ? 171.283 139.355 128.363 1.00 33.99  ?  931  LEU   C CD1   1 
ATOM   5714 C CD2   . LEU   A 1 931  ? 173.692 140.022 128.422 1.00 37.22  ?  931  LEU   C CD2   1 
ATOM   5715 N N     . LEU   A 1 932  ? 171.892 142.157 133.053 1.00 32.60  ?  932  LEU   C N     1 
ATOM   5716 C CA    . LEU   A 1 932  ? 171.606 143.373 133.799 1.00 29.95  ?  932  LEU   C CA    1 
ATOM   5717 C C     . LEU   A 1 932  ? 172.773 143.726 134.700 1.00 31.94  ?  932  LEU   C C     1 
ATOM   5718 O O     . LEU   A 1 932  ? 173.121 144.897 134.844 1.00 30.87  ?  932  LEU   C O     1 
ATOM   5719 C CB    . LEU   A 1 932  ? 170.340 143.216 134.651 1.00 29.54  ?  932  LEU   C CB    1 
ATOM   5720 C CG    . LEU   A 1 932  ? 169.001 143.114 133.891 1.00 29.90  ?  932  LEU   C CG    1 
ATOM   5721 C CD1   . LEU   A 1 932  ? 167.896 142.765 134.878 1.00 25.51  ?  932  LEU   C CD1   1 
ATOM   5722 C CD2   . LEU   A 1 932  ? 168.694 144.435 133.185 1.00 27.72  ?  932  LEU   C CD2   1 
ATOM   5723 N N     . CYS   A 1 933  ? 173.404 142.706 135.277 1.00 36.60  ?  933  CYS   C N     1 
ATOM   5724 C CA    . CYS   A 1 933  ? 174.530 142.910 136.176 1.00 33.81  ?  933  CYS   C CA    1 
ATOM   5725 C C     . CYS   A 1 933  ? 175.695 143.591 135.477 1.00 34.14  ?  933  CYS   C C     1 
ATOM   5726 O O     . CYS   A 1 933  ? 176.422 144.373 136.084 1.00 35.03  ?  933  CYS   C O     1 
ATOM   5727 C CB    . CYS   A 1 933  ? 174.976 141.592 136.787 1.00 37.20  ?  933  CYS   C CB    1 
ATOM   5728 S SG    . CYS   A 1 933  ? 173.789 140.932 137.974 1.00 44.47  ?  933  CYS   C SG    1 
ATOM   5729 N N     . GLU   A 1 934  ? 175.856 143.352 134.183 1.00 36.62  ?  934  GLU   C N     1 
ATOM   5730 C CA    . GLU   A 1 934  ? 176.927 144.029 133.468 1.00 37.21  ?  934  GLU   C CA    1 
ATOM   5731 C C     . GLU   A 1 934  ? 176.767 145.546 133.594 1.00 36.74  ?  934  GLU   C C     1 
ATOM   5732 O O     . GLU   A 1 934  ? 177.755 146.277 133.661 1.00 36.46  ?  934  GLU   C O     1 
ATOM   5733 C CB    . GLU   A 1 934  ? 176.950 143.619 131.993 1.00 39.77  ?  934  GLU   C CB    1 
ATOM   5734 C CG    . GLU   A 1 934  ? 177.412 142.183 131.742 1.00 47.44  ?  934  GLU   C CG    1 
ATOM   5735 C CD    . GLU   A 1 934  ? 177.406 141.798 130.278 1.00 56.08  ?  934  GLU   C CD    1 
ATOM   5736 O OE1   . GLU   A 1 934  ? 176.852 142.528 129.493 1.00 49.41  ?  934  GLU   C OE1   1 
ATOM   5737 O OE2   . GLU   A 1 934  ? 177.960 140.774 129.951 1.00 56.30  -1 934  GLU   C OE2   1 
ATOM   5738 N N     . GLY   A 1 935  ? 175.518 146.014 133.627 1.00 35.60  ?  935  GLY   C N     1 
ATOM   5739 C CA    . GLY   A 1 935  ? 175.227 147.434 133.782 1.00 34.09  ?  935  GLY   C CA    1 
ATOM   5740 C C     . GLY   A 1 935  ? 175.188 147.834 135.254 1.00 33.23  ?  935  GLY   C C     1 
ATOM   5741 O O     . GLY   A 1 935  ? 175.759 148.845 135.656 1.00 34.17  ?  935  GLY   C O     1 
ATOM   5742 N N     . LEU   A 1 936  ? 174.529 147.024 136.073 1.00 31.41  ?  936  LEU   C N     1 
ATOM   5743 C CA    . LEU   A 1 936  ? 174.357 147.345 137.486 1.00 29.38  ?  936  LEU   C CA    1 
ATOM   5744 C C     . LEU   A 1 936  ? 175.691 147.429 138.211 1.00 33.72  ?  936  LEU   C C     1 
ATOM   5745 O O     . LEU   A 1 936  ? 175.844 148.192 139.165 1.00 34.92  ?  936  LEU   C O     1 
ATOM   5746 C CB    . LEU   A 1 936  ? 173.492 146.287 138.162 1.00 29.81  ?  936  LEU   C CB    1 
ATOM   5747 C CG    . LEU   A 1 936  ? 172.039 146.206 137.710 1.00 30.63  ?  936  LEU   C CG    1 
ATOM   5748 C CD1   . LEU   A 1 936  ? 171.431 144.915 138.215 1.00 31.68  ?  936  LEU   C CD1   1 
ATOM   5749 C CD2   . LEU   A 1 936  ? 171.275 147.392 138.259 1.00 26.41  ?  936  LEU   C CD2   1 
ATOM   5750 N N     . LEU   A 1 937  ? 176.662 146.642 137.762 1.00 36.89  ?  937  LEU   C N     1 
ATOM   5751 C CA    . LEU   A 1 937  ? 177.979 146.615 138.382 1.00 37.57  ?  937  LEU   C CA    1 
ATOM   5752 C C     . LEU   A 1 937  ? 178.875 147.736 137.861 1.00 37.35  ?  937  LEU   C C     1 
ATOM   5753 O O     . LEU   A 1 937  ? 180.018 147.876 138.298 1.00 38.24  ?  937  LEU   C O     1 
ATOM   5754 C CB    . LEU   A 1 937  ? 178.650 145.262 138.107 1.00 38.53  ?  937  LEU   C CB    1 
ATOM   5755 C CG    . LEU   A 1 937  ? 177.937 144.003 138.679 1.00 42.85  ?  937  LEU   C CG    1 
ATOM   5756 C CD1   . LEU   A 1 937  ? 178.628 142.754 138.146 1.00 45.63  ?  937  LEU   C CD1   1 
ATOM   5757 C CD2   . LEU   A 1 937  ? 177.983 144.019 140.184 1.00 45.60  ?  937  LEU   C CD2   1 
ATOM   5758 N N     . HIS   A 1 938  ? 178.366 148.521 136.915 1.00 35.74  ?  938  HIS   C N     1 
ATOM   5759 C CA    . HIS   A 1 938  ? 179.120 149.618 136.332 1.00 37.86  ?  938  HIS   C CA    1 
ATOM   5760 C C     . HIS   A 1 938  ? 179.324 150.711 137.384 1.00 37.86  ?  938  HIS   C C     1 
ATOM   5761 O O     . HIS   A 1 938  ? 178.382 151.058 138.097 1.00 37.37  ?  938  HIS   C O     1 
ATOM   5762 C CB    . HIS   A 1 938  ? 178.364 150.178 135.117 1.00 37.44  ?  938  HIS   C CB    1 
ATOM   5763 C CG    . HIS   A 1 938  ? 179.148 151.113 134.270 1.00 38.48  ?  938  HIS   C CG    1 
ATOM   5764 N ND1   . HIS   A 1 938  ? 179.442 152.402 134.656 1.00 40.52  ?  938  HIS   C ND1   1 
ATOM   5765 C CD2   . HIS   A 1 938  ? 179.702 150.948 133.051 1.00 39.33  ?  938  HIS   C CD2   1 
ATOM   5766 C CE1   . HIS   A 1 938  ? 180.151 152.987 133.704 1.00 42.45  ?  938  HIS   C CE1   1 
ATOM   5767 N NE2   . HIS   A 1 938  ? 180.320 152.125 132.723 1.00 42.86  ?  938  HIS   C NE2   1 
ATOM   5768 N N     . PRO   A 1 939  ? 180.527 151.288 137.498 1.00 38.92  ?  939  PRO   C N     1 
ATOM   5769 C CA    . PRO   A 1 939  ? 180.898 152.298 138.475 1.00 40.65  ?  939  PRO   C CA    1 
ATOM   5770 C C     . PRO   A 1 939  ? 180.055 153.572 138.413 1.00 41.95  ?  939  PRO   C C     1 
ATOM   5771 O O     . PRO   A 1 939  ? 179.951 154.288 139.407 1.00 40.97  ?  939  PRO   C O     1 
ATOM   5772 C CB    . PRO   A 1 939  ? 182.368 152.579 138.127 1.00 41.39  ?  939  PRO   C CB    1 
ATOM   5773 C CG    . PRO   A 1 939  ? 182.554 152.070 136.719 1.00 42.85  ?  939  PRO   C CG    1 
ATOM   5774 C CD    . PRO   A 1 939  ? 181.626 150.895 136.603 1.00 38.71  ?  939  PRO   C CD    1 
ATOM   5775 N N     . ASP   A 1 940  ? 179.452 153.862 137.261 1.00 41.49  ?  940  ASP   C N     1 
ATOM   5776 C CA    . ASP   A 1 940  ? 178.658 155.080 137.136 1.00 40.58  ?  940  ASP   C CA    1 
ATOM   5777 C C     . ASP   A 1 940  ? 177.160 154.829 137.279 1.00 39.29  ?  940  ASP   C C     1 
ATOM   5778 O O     . ASP   A 1 940  ? 176.357 155.742 137.085 1.00 38.37  ?  940  ASP   C O     1 
ATOM   5779 C CB    . ASP   A 1 940  ? 178.920 155.757 135.789 1.00 45.54  ?  940  ASP   C CB    1 
ATOM   5780 C CG    . ASP   A 1 940  ? 180.360 156.246 135.619 1.00 53.82  ?  940  ASP   C CG    1 
ATOM   5781 O OD1   . ASP   A 1 940  ? 180.995 156.557 136.598 1.00 55.70  ?  940  ASP   C OD1   1 
ATOM   5782 O OD2   . ASP   A 1 940  ? 180.805 156.322 134.496 1.00 48.42  -1 940  ASP   C OD2   1 
ATOM   5783 N N     . CYS   A 1 941  ? 176.774 153.602 137.608 1.00 35.81  ?  941  CYS   C N     1 
ATOM   5784 C CA    . CYS   A 1 941  ? 175.357 153.294 137.752 1.00 30.09  ?  941  CYS   C CA    1 
ATOM   5785 C C     . CYS   A 1 941  ? 174.861 153.773 139.107 1.00 27.24  ?  941  CYS   C C     1 
ATOM   5786 O O     . CYS   A 1 941  ? 175.493 153.516 140.130 1.00 30.70  ?  941  CYS   C O     1 
ATOM   5787 C CB    . CYS   A 1 941  ? 175.094 151.796 137.614 1.00 33.18  ?  941  CYS   C CB    1 
ATOM   5788 S SG    . CYS   A 1 941  ? 173.340 151.363 137.692 1.00 32.70  ?  941  CYS   C SG    1 
ATOM   5789 N N     . LYS   A 1 942  ? 173.744 154.491 139.116 1.00 26.03  ?  942  LYS   C N     1 
ATOM   5790 C CA    . LYS   A 1 942  ? 173.217 155.043 140.357 1.00 23.75  ?  942  LYS   C CA    1 
ATOM   5791 C C     . LYS   A 1 942  ? 171.841 154.495 140.730 1.00 18.98  ?  942  LYS   C C     1 
ATOM   5792 O O     . LYS   A 1 942  ? 171.117 155.108 141.514 1.00 19.84  ?  942  LYS   C O     1 
ATOM   5793 C CB    . LYS   A 1 942  ? 173.181 156.568 140.278 1.00 24.15  ?  942  LYS   C CB    1 
ATOM   5794 C CG    . LYS   A 1 942  ? 174.562 157.197 140.119 1.00 27.58  ?  942  LYS   C CG    1 
ATOM   5795 C CD    . LYS   A 1 942  ? 174.513 158.711 140.221 1.00 33.66  ?  942  LYS   C CD    1 
ATOM   5796 C CE    . LYS   A 1 942  ? 175.894 159.321 139.990 1.00 41.08  ?  942  LYS   C CE    1 
ATOM   5797 N NZ    . LYS   A 1 942  ? 175.885 160.804 140.152 1.00 43.65  1  942  LYS   C NZ    1 
ATOM   5798 N N     . LEU   A 1 943  ? 171.474 153.347 140.173 1.00 18.45  ?  943  LEU   C N     1 
ATOM   5799 C CA    . LEU   A 1 943  ? 170.176 152.751 140.467 1.00 15.70  ?  943  LEU   C CA    1 
ATOM   5800 C C     . LEU   A 1 943  ? 170.048 152.477 141.960 1.00 16.92  ?  943  LEU   C C     1 
ATOM   5801 O O     . LEU   A 1 943  ? 170.965 151.920 142.568 1.00 22.77  ?  943  LEU   C O     1 
ATOM   5802 C CB    . LEU   A 1 943  ? 169.990 151.437 139.696 1.00 14.70  ?  943  LEU   C CB    1 
ATOM   5803 C CG    . LEU   A 1 943  ? 168.560 150.849 139.695 1.00 14.12  ?  943  LEU   C CG    1 
ATOM   5804 C CD1   . LEU   A 1 943  ? 167.665 151.701 138.806 1.00 15.46  ?  943  LEU   C CD1   1 
ATOM   5805 C CD2   . LEU   A 1 943  ? 168.590 149.414 139.210 1.00 16.17  ?  943  LEU   C CD2   1 
ATOM   5806 N N     . GLN   A 1 944  ? 168.923 152.859 142.558 1.00 16.95  ?  944  GLN   C N     1 
ATOM   5807 C CA    . GLN   A 1 944  ? 168.721 152.654 143.984 1.00 16.37  ?  944  GLN   C CA    1 
ATOM   5808 C C     . GLN   A 1 944  ? 167.769 151.505 144.271 1.00 15.22  ?  944  GLN   C C     1 
ATOM   5809 O O     . GLN   A 1 944  ? 167.969 150.748 145.221 1.00 19.73  ?  944  GLN   C O     1 
ATOM   5810 C CB    . GLN   A 1 944  ? 168.179 153.924 144.632 1.00 16.45  ?  944  GLN   C CB    1 
ATOM   5811 C CG    . GLN   A 1 944  ? 169.129 155.090 144.596 1.00 19.19  ?  944  GLN   C CG    1 
ATOM   5812 C CD    . GLN   A 1 944  ? 168.532 156.318 145.229 1.00 22.91  ?  944  GLN   C CD    1 
ATOM   5813 O OE1   . GLN   A 1 944  ? 167.455 156.255 145.828 1.00 23.69  ?  944  GLN   C OE1   1 
ATOM   5814 N NE2   . GLN   A 1 944  ? 169.215 157.446 145.101 1.00 24.79  ?  944  GLN   C NE2   1 
ATOM   5815 N N     . VAL   A 1 945  ? 166.724 151.390 143.464 1.00 12.84  ?  945  VAL   C N     1 
ATOM   5816 C CA    . VAL   A 1 945  ? 165.720 150.362 143.685 1.00 11.99  ?  945  VAL   C CA    1 
ATOM   5817 C C     . VAL   A 1 945  ? 165.559 149.459 142.482 1.00 11.91  ?  945  VAL   C C     1 
ATOM   5818 O O     . VAL   A 1 945  ? 165.268 149.920 141.380 1.00 13.88  ?  945  VAL   C O     1 
ATOM   5819 C CB    . VAL   A 1 945  ? 164.362 151.001 144.003 1.00 11.58  ?  945  VAL   C CB    1 
ATOM   5820 C CG1   . VAL   A 1 945  ? 163.311 149.917 144.204 1.00 11.59  ?  945  VAL   C CG1   1 
ATOM   5821 C CG2   . VAL   A 1 945  ? 164.496 151.873 145.239 1.00 13.81  ?  945  VAL   C CG2   1 
ATOM   5822 N N     . LEU   A 1 946  ? 165.721 148.164 142.709 1.00 12.72  ?  946  LEU   C N     1 
ATOM   5823 C CA    . LEU   A 1 946  ? 165.553 147.191 141.646 1.00 11.70  ?  946  LEU   C CA    1 
ATOM   5824 C C     . LEU   A 1 946  ? 164.569 146.103 142.043 1.00 12.48  ?  946  LEU   C C     1 
ATOM   5825 O O     . LEU   A 1 946  ? 164.825 145.323 142.961 1.00 18.34  ?  946  LEU   C O     1 
ATOM   5826 C CB    . LEU   A 1 946  ? 166.918 146.588 141.297 1.00 15.08  ?  946  LEU   C CB    1 
ATOM   5827 C CG    . LEU   A 1 946  ? 166.938 145.462 140.269 1.00 13.68  ?  946  LEU   C CG    1 
ATOM   5828 C CD1   . LEU   A 1 946  ? 166.375 145.946 138.941 1.00 13.45  ?  946  LEU   C CD1   1 
ATOM   5829 C CD2   . LEU   A 1 946  ? 168.371 145.003 140.095 1.00 21.29  ?  946  LEU   C CD2   1 
ATOM   5830 N N     . GLU   A 1 947  ? 163.446 146.048 141.340 1.00 11.08  ?  947  GLU   C N     1 
ATOM   5831 C CA    . GLU   A 1 947  ? 162.426 145.055 141.641 1.00 13.17  ?  947  GLU   C CA    1 
ATOM   5832 C C     . GLU   A 1 947  ? 162.423 143.942 140.603 1.00 14.66  ?  947  GLU   C C     1 
ATOM   5833 O O     . GLU   A 1 947  ? 162.176 144.176 139.420 1.00 15.26  ?  947  GLU   C O     1 
ATOM   5834 C CB    . GLU   A 1 947  ? 161.051 145.711 141.731 1.00 14.57  ?  947  GLU   C CB    1 
ATOM   5835 C CG    . GLU   A 1 947  ? 159.934 144.765 142.111 1.00 18.60  ?  947  GLU   C CG    1 
ATOM   5836 C CD    . GLU   A 1 947  ? 158.612 145.450 142.243 1.00 24.45  ?  947  GLU   C CD    1 
ATOM   5837 O OE1   . GLU   A 1 947  ? 158.086 145.880 141.246 1.00 22.30  ?  947  GLU   C OE1   1 
ATOM   5838 O OE2   . GLU   A 1 947  ? 158.120 145.542 143.340 1.00 24.27  -1 947  GLU   C OE2   1 
ATOM   5839 N N     . LEU   A 1 948  ? 162.714 142.728 141.058 1.00 17.31  ?  948  LEU   C N     1 
ATOM   5840 C CA    . LEU   A 1 948  ? 162.811 141.561 140.192 1.00 16.73  ?  948  LEU   C CA    1 
ATOM   5841 C C     . LEU   A 1 948  ? 161.896 140.447 140.659 1.00 17.04  ?  948  LEU   C C     1 
ATOM   5842 O O     . LEU   A 1 948  ? 162.231 139.269 140.553 1.00 20.95  ?  948  LEU   C O     1 
ATOM   5843 C CB    . LEU   A 1 948  ? 164.245 141.042 140.164 1.00 17.20  ?  948  LEU   C CB    1 
ATOM   5844 C CG    . LEU   A 1 948  ? 165.281 141.965 139.571 1.00 15.42  ?  948  LEU   C CG    1 
ATOM   5845 C CD1   . LEU   A 1 948  ? 166.646 141.469 139.974 1.00 21.71  ?  948  LEU   C CD1   1 
ATOM   5846 C CD2   . LEU   A 1 948  ? 165.140 141.990 138.060 1.00 17.62  ?  948  LEU   C CD2   1 
ATOM   5847 N N     . ASP   A 1 949  ? 160.743 140.813 141.182 1.00 17.41  ?  949  ASP   C N     1 
ATOM   5848 C CA    . ASP   A 1 949  ? 159.779 139.822 141.618 1.00 18.00  ?  949  ASP   C CA    1 
ATOM   5849 C C     . ASP   A 1 949  ? 159.213 139.060 140.432 1.00 18.56  ?  949  ASP   C C     1 
ATOM   5850 O O     . ASP   A 1 949  ? 159.071 139.609 139.342 1.00 20.39  ?  949  ASP   C O     1 
ATOM   5851 C CB    . ASP   A 1 949  ? 158.655 140.486 142.418 1.00 20.24  ?  949  ASP   C CB    1 
ATOM   5852 C CG    . ASP   A 1 949  ? 157.615 139.506 142.922 1.00 27.48  ?  949  ASP   C CG    1 
ATOM   5853 O OD1   . ASP   A 1 949  ? 157.820 138.319 142.766 1.00 30.52  ?  949  ASP   C OD1   1 
ATOM   5854 O OD2   . ASP   A 1 949  ? 156.628 139.940 143.464 1.00 28.20  -1 949  ASP   C OD2   1 
ATOM   5855 N N     . ASN   A 1 950  ? 158.920 137.794 140.641 1.00 20.74  ?  950  ASN   C N     1 
ATOM   5856 C CA    . ASN   A 1 950  ? 158.283 136.965 139.635 1.00 17.85  ?  950  ASN   C CA    1 
ATOM   5857 C C     . ASN   A 1 950  ? 158.952 137.087 138.276 1.00 18.94  ?  950  ASN   C C     1 
ATOM   5858 O O     . ASN   A 1 950  ? 158.272 137.288 137.275 1.00 21.80  ?  950  ASN   C O     1 
ATOM   5859 C CB    . ASN   A 1 950  ? 156.811 137.306 139.541 1.00 16.82  ?  950  ASN   C CB    1 
ATOM   5860 C CG    . ASN   A 1 950  ? 156.034 136.265 138.820 1.00 19.05  ?  950  ASN   C CG    1 
ATOM   5861 O OD1   . ASN   A 1 950  ? 156.487 135.127 138.687 1.00 23.70  ?  950  ASN   C OD1   1 
ATOM   5862 N ND2   . ASN   A 1 950  ? 154.866 136.619 138.353 1.00 20.97  ?  950  ASN   C ND2   1 
ATOM   5863 N N     . CYS   A 1 951  ? 160.278 136.973 138.234 1.00 20.46  ?  951  CYS   C N     1 
ATOM   5864 C CA    . CYS   A 1 951  ? 161.012 137.098 136.975 1.00 21.20  ?  951  CYS   C CA    1 
ATOM   5865 C C     . CYS   A 1 951  ? 161.546 135.772 136.449 1.00 26.47  ?  951  CYS   C C     1 
ATOM   5866 O O     . CYS   A 1 951  ? 162.423 135.748 135.580 1.00 28.35  ?  951  CYS   C O     1 
ATOM   5867 C CB    . CYS   A 1 951  ? 162.169 138.078 137.122 1.00 21.91  ?  951  CYS   C CB    1 
ATOM   5868 S SG    . CYS   A 1 951  ? 161.651 139.771 137.284 1.00 24.22  ?  951  CYS   C SG    1 
ATOM   5869 N N     . ASN   A 1 952  ? 160.988 134.673 136.957 1.00 27.67  ?  952  ASN   C N     1 
ATOM   5870 C CA    . ASN   A 1 952  ? 161.379 133.325 136.559 1.00 27.11  ?  952  ASN   C CA    1 
ATOM   5871 C C     . ASN   A 1 952  ? 162.860 133.060 136.804 1.00 29.24  ?  952  ASN   C C     1 
ATOM   5872 O O     . ASN   A 1 952  ? 163.546 132.495 135.955 1.00 32.49  ?  952  ASN   C O     1 
ATOM   5873 C CB    . ASN   A 1 952  ? 161.043 133.087 135.101 1.00 29.40  ?  952  ASN   C CB    1 
ATOM   5874 C CG    . ASN   A 1 952  ? 160.992 131.636 134.746 1.00 35.67  ?  952  ASN   C CG    1 
ATOM   5875 O OD1   . ASN   A 1 952  ? 160.601 130.798 135.568 1.00 37.18  ?  952  ASN   C OD1   1 
ATOM   5876 N ND2   . ASN   A 1 952  ? 161.373 131.316 133.534 1.00 36.36  ?  952  ASN   C ND2   1 
ATOM   5877 N N     . LEU   A 1 953  ? 163.346 133.467 137.970 1.00 29.53  ?  953  LEU   C N     1 
ATOM   5878 C CA    . LEU   A 1 953  ? 164.750 133.303 138.321 1.00 33.74  ?  953  LEU   C CA    1 
ATOM   5879 C C     . LEU   A 1 953  ? 164.949 132.101 139.222 1.00 39.65  ?  953  LEU   C C     1 
ATOM   5880 O O     . LEU   A 1 953  ? 164.052 131.739 139.985 1.00 40.01  ?  953  LEU   C O     1 
ATOM   5881 C CB    . LEU   A 1 953  ? 165.242 134.537 139.069 1.00 32.78  ?  953  LEU   C CB    1 
ATOM   5882 C CG    . LEU   A 1 953  ? 164.943 135.862 138.423 1.00 32.04  ?  953  LEU   C CG    1 
ATOM   5883 C CD1   . LEU   A 1 953  ? 165.455 136.973 139.324 1.00 30.74  ?  953  LEU   C CD1   1 
ATOM   5884 C CD2   . LEU   A 1 953  ? 165.573 135.910 137.054 1.00 34.80  ?  953  LEU   C CD2   1 
ATOM   5885 N N     . THR   A 1 954  ? 166.136 131.506 139.179 1.00 42.16  ?  954  THR   C N     1 
ATOM   5886 C CA    . THR   A 1 954  ? 166.416 130.414 140.098 1.00 44.22  ?  954  THR   C CA    1 
ATOM   5887 C C     . THR   A 1 954  ? 167.780 130.536 140.760 1.00 48.28  ?  954  THR   C C     1 
ATOM   5888 O O     . THR   A 1 954  ? 168.435 131.574 140.684 1.00 49.76  ?  954  THR   C O     1 
ATOM   5889 C CB    . THR   A 1 954  ? 166.262 129.045 139.417 1.00 46.59  ?  954  THR   C CB    1 
ATOM   5890 O OG1   . THR   A 1 954  ? 166.322 128.023 140.421 1.00 48.83  ?  954  THR   C OG1   1 
ATOM   5891 C CG2   . THR   A 1 954  ? 167.342 128.812 138.378 1.00 48.68  ?  954  THR   C CG2   1 
ATOM   5892 N N     . SER   A 1 955  ? 168.185 129.479 141.450 1.00 49.27  ?  955  SER   C N     1 
ATOM   5893 C CA    . SER   A 1 955  ? 169.374 129.499 142.289 1.00 50.45  ?  955  SER   C CA    1 
ATOM   5894 C C     . SER   A 1 955  ? 170.660 129.775 141.517 1.00 50.61  ?  955  SER   C C     1 
ATOM   5895 O O     . SER   A 1 955  ? 171.646 130.241 142.087 1.00 50.99  ?  955  SER   C O     1 
ATOM   5896 C CB    . SER   A 1 955  ? 169.498 128.179 143.014 1.00 52.17  ?  955  SER   C CB    1 
ATOM   5897 O OG    . SER   A 1 955  ? 169.805 127.145 142.123 1.00 56.89  ?  955  SER   C OG    1 
ATOM   5898 N N     . HIS   A 1 956  ? 170.643 129.530 140.217 1.00 50.29  ?  956  HIS   C N     1 
ATOM   5899 C CA    . HIS   A 1 956  ? 171.829 129.693 139.387 1.00 52.83  ?  956  HIS   C CA    1 
ATOM   5900 C C     . HIS   A 1 956  ? 172.186 131.159 139.160 1.00 51.60  ?  956  HIS   C C     1 
ATOM   5901 O O     . HIS   A 1 956  ? 173.278 131.476 138.690 1.00 51.82  ?  956  HIS   C O     1 
ATOM   5902 C CB    . HIS   A 1 956  ? 171.634 128.998 138.043 1.00 51.32  ?  956  HIS   C CB    1 
ATOM   5903 C CG    . HIS   A 1 956  ? 171.599 127.513 138.139 1.00 61.35  ?  956  HIS   C CG    1 
ATOM   5904 N ND1   . HIS   A 1 956  ? 172.699 126.765 138.496 1.00 66.43  ?  956  HIS   C ND1   1 
ATOM   5905 C CD2   . HIS   A 1 956  ? 170.597 126.631 137.923 1.00 65.50  ?  956  HIS   C CD2   1 
ATOM   5906 C CE1   . HIS   A 1 956  ? 172.373 125.483 138.496 1.00 61.05  ?  956  HIS   C CE1   1 
ATOM   5907 N NE2   . HIS   A 1 956  ? 171.104 125.376 138.150 1.00 57.66  ?  956  HIS   C NE2   1 
ATOM   5908 N N     . CYS   A 1 957  ? 171.276 132.068 139.495 1.00 51.54  ?  957  CYS   C N     1 
ATOM   5909 C CA    . CYS   A 1 957  ? 171.557 133.492 139.328 1.00 50.97  ?  957  CYS   C CA    1 
ATOM   5910 C C     . CYS   A 1 957  ? 172.032 134.119 140.627 1.00 49.17  ?  957  CYS   C C     1 
ATOM   5911 O O     . CYS   A 1 957  ? 172.318 135.318 140.679 1.00 48.07  ?  957  CYS   C O     1 
ATOM   5912 C CB    . CYS   A 1 957  ? 170.324 134.258 138.863 1.00 47.58  ?  957  CYS   C CB    1 
ATOM   5913 S SG    . CYS   A 1 957  ? 169.050 134.433 140.120 1.00 52.60  ?  957  CYS   C SG    1 
ATOM   5914 N N     . CYS   A 1 958  ? 172.074 133.328 141.693 1.00 48.28  ?  958  CYS   C N     1 
ATOM   5915 C CA    . CYS   A 1 958  ? 172.388 133.879 142.997 1.00 47.80  ?  958  CYS   C CA    1 
ATOM   5916 C C     . CYS   A 1 958  ? 173.814 134.383 143.075 1.00 47.91  ?  958  CYS   C C     1 
ATOM   5917 O O     . CYS   A 1 958  ? 174.098 135.341 143.790 1.00 48.10  ?  958  CYS   C O     1 
ATOM   5918 C CB    . CYS   A 1 958  ? 172.143 132.849 144.077 1.00 49.40  ?  958  CYS   C CB    1 
ATOM   5919 S SG    . CYS   A 1 958  ? 170.430 132.473 144.276 1.00 54.45  ?  958  CYS   C SG    1 
ATOM   5920 N N     . TRP   A 1 959  ? 174.717 133.754 142.342 1.00 49.31  ?  959  TRP   C N     1 
ATOM   5921 C CA    . TRP   A 1 959  ? 176.105 134.184 142.359 1.00 51.66  ?  959  TRP   C CA    1 
ATOM   5922 C C     . TRP   A 1 959  ? 176.215 135.628 141.887 1.00 62.57  ?  959  TRP   C C     1 
ATOM   5923 O O     . TRP   A 1 959  ? 177.008 136.409 142.422 1.00 53.11  ?  959  TRP   C O     1 
ATOM   5924 C CB    . TRP   A 1 959  ? 176.972 133.275 141.498 1.00 54.17  ?  959  TRP   C CB    1 
ATOM   5925 C CG    . TRP   A 1 959  ? 178.405 133.619 141.592 1.00 53.26  ?  959  TRP   C CG    1 
ATOM   5926 C CD1   . TRP   A 1 959  ? 179.298 133.146 142.501 1.00 59.39  ?  959  TRP   C CD1   1 
ATOM   5927 C CD2   . TRP   A 1 959  ? 179.135 134.529 140.747 1.00 60.21  ?  959  TRP   C CD2   1 
ATOM   5928 N NE1   . TRP   A 1 959  ? 180.532 133.699 142.280 1.00 60.65  ?  959  TRP   C NE1   1 
ATOM   5929 C CE2   . TRP   A 1 959  ? 180.450 134.548 141.210 1.00 61.99  ?  959  TRP   C CE2   1 
ATOM   5930 C CE3   . TRP   A 1 959  ? 178.782 135.320 139.653 1.00 60.76  ?  959  TRP   C CE3   1 
ATOM   5931 C CZ2   . TRP   A 1 959  ? 181.420 135.329 140.618 1.00 59.98  ?  959  TRP   C CZ2   1 
ATOM   5932 C CZ3   . TRP   A 1 959  ? 179.753 136.104 139.058 1.00 60.68  ?  959  TRP   C CZ3   1 
ATOM   5933 C CH2   . TRP   A 1 959  ? 181.040 136.110 139.527 1.00 61.06  ?  959  TRP   C CH2   1 
ATOM   5934 N N     . ASP   A 1 960  ? 175.427 135.977 140.872 1.00 52.03  ?  960  ASP   C N     1 
ATOM   5935 C CA    . ASP   A 1 960  ? 175.483 137.308 140.291 1.00 49.96  ?  960  ASP   C CA    1 
ATOM   5936 C C     . ASP   A 1 960  ? 174.746 138.307 141.169 1.00 45.54  ?  960  ASP   C C     1 
ATOM   5937 O O     . ASP   A 1 960  ? 175.187 139.447 141.323 1.00 45.14  ?  960  ASP   C O     1 
ATOM   5938 C CB    . ASP   A 1 960  ? 174.870 137.293 138.892 1.00 51.04  ?  960  ASP   C CB    1 
ATOM   5939 C CG    . ASP   A 1 960  ? 175.692 136.492 137.899 1.00 54.52  ?  960  ASP   C CG    1 
ATOM   5940 O OD1   . ASP   A 1 960  ? 176.722 136.963 137.485 1.00 55.63  ?  960  ASP   C OD1   1 
ATOM   5941 O OD2   . ASP   A 1 960  ? 175.288 135.401 137.572 1.00 55.33  -1 960  ASP   C OD2   1 
ATOM   5942 N N     . LEU   A 1 961  ? 173.650 137.871 141.780 1.00 45.13  ?  961  LEU   C N     1 
ATOM   5943 C CA    . LEU   A 1 961  ? 172.921 138.740 142.692 1.00 45.00  ?  961  LEU   C CA    1 
ATOM   5944 C C     . LEU   A 1 961  ? 173.764 139.011 143.930 1.00 45.00  ?  961  LEU   C C     1 
ATOM   5945 O O     . LEU   A 1 961  ? 173.776 140.125 144.452 1.00 46.19  ?  961  LEU   C O     1 
ATOM   5946 C CB    . LEU   A 1 961  ? 171.584 138.103 143.084 1.00 44.19  ?  961  LEU   C CB    1 
ATOM   5947 C CG    . LEU   A 1 961  ? 170.518 138.007 141.965 1.00 45.29  ?  961  LEU   C CG    1 
ATOM   5948 C CD1   . LEU   A 1 961  ? 169.370 137.144 142.446 1.00 40.80  ?  961  LEU   C CD1   1 
ATOM   5949 C CD2   . LEU   A 1 961  ? 170.012 139.403 141.602 1.00 42.84  ?  961  LEU   C CD2   1 
ATOM   5950 N N     . SER   A 1 962  ? 174.495 137.996 144.381 1.00 47.97  ?  962  SER   C N     1 
ATOM   5951 C CA    . SER   A 1 962  ? 175.386 138.144 145.521 1.00 47.02  ?  962  SER   C CA    1 
ATOM   5952 C C     . SER   A 1 962  ? 176.492 139.130 145.179 1.00 44.96  ?  962  SER   C C     1 
ATOM   5953 O O     . SER   A 1 962  ? 176.811 140.023 145.968 1.00 46.31  ?  962  SER   C O     1 
ATOM   5954 C CB    . SER   A 1 962  ? 175.969 136.802 145.910 1.00 53.26  ?  962  SER   C CB    1 
ATOM   5955 O OG    . SER   A 1 962  ? 176.830 136.928 147.004 1.00 59.76  ?  962  SER   C OG    1 
ATOM   5956 N N     . THR   A 1 963  ? 177.044 138.996 143.977 1.00 44.87  ?  963  THR   C N     1 
ATOM   5957 C CA    . THR   A 1 963  ? 178.079 139.901 143.509 1.00 46.21  ?  963  THR   C CA    1 
ATOM   5958 C C     . THR   A 1 963  ? 177.568 141.334 143.516 1.00 46.65  ?  963  THR   C C     1 
ATOM   5959 O O     . THR   A 1 963  ? 178.267 142.246 143.957 1.00 45.31  ?  963  THR   C O     1 
ATOM   5960 C CB    . THR   A 1 963  ? 178.544 139.515 142.094 1.00 47.91  ?  963  THR   C CB    1 
ATOM   5961 O OG1   . THR   A 1 963  ? 179.093 138.191 142.121 1.00 51.81  ?  963  THR   C OG1   1 
ATOM   5962 C CG2   . THR   A 1 963  ? 179.601 140.486 141.597 1.00 51.45  ?  963  THR   C CG2   1 
ATOM   5963 N N     . LEU   A 1 964  ? 176.336 141.528 143.048 1.00 45.63  ?  964  LEU   C N     1 
ATOM   5964 C CA    . LEU   A 1 964  ? 175.713 142.845 143.042 1.00 43.75  ?  964  LEU   C CA    1 
ATOM   5965 C C     . LEU   A 1 964  ? 175.633 143.414 144.453 1.00 42.92  ?  964  LEU   C C     1 
ATOM   5966 O O     . LEU   A 1 964  ? 176.017 144.559 144.700 1.00 42.04  ?  964  LEU   C O     1 
ATOM   5967 C CB    . LEU   A 1 964  ? 174.299 142.741 142.451 1.00 43.80  ?  964  LEU   C CB    1 
ATOM   5968 C CG    . LEU   A 1 964  ? 173.468 144.020 142.409 1.00 41.60  ?  964  LEU   C CG    1 
ATOM   5969 C CD1   . LEU   A 1 964  ? 174.131 145.027 141.484 1.00 40.48  ?  964  LEU   C CD1   1 
ATOM   5970 C CD2   . LEU   A 1 964  ? 172.058 143.675 141.939 1.00 38.62  ?  964  LEU   C CD2   1 
ATOM   5971 N N     . LEU   A 1 965  ? 175.170 142.599 145.391 1.00 43.05  ?  965  LEU   C N     1 
ATOM   5972 C CA    . LEU   A 1 965  ? 175.001 143.039 146.770 1.00 41.05  ?  965  LEU   C CA    1 
ATOM   5973 C C     . LEU   A 1 965  ? 176.304 143.495 147.408 1.00 42.91  ?  965  LEU   C C     1 
ATOM   5974 O O     . LEU   A 1 965  ? 176.306 144.396 148.245 1.00 44.60  ?  965  LEU   C O     1 
ATOM   5975 C CB    . LEU   A 1 965  ? 174.400 141.905 147.606 1.00 41.65  ?  965  LEU   C CB    1 
ATOM   5976 C CG    . LEU   A 1 965  ? 172.931 141.554 147.318 1.00 42.26  ?  965  LEU   C CG    1 
ATOM   5977 C CD1   . LEU   A 1 965  ? 172.572 140.243 148.027 1.00 49.44  ?  965  LEU   C CD1   1 
ATOM   5978 C CD2   . LEU   A 1 965  ? 172.047 142.688 147.807 1.00 39.39  ?  965  LEU   C CD2   1 
ATOM   5979 N N     . THR   A 1 966  ? 177.414 142.881 147.020 1.00 44.43  ?  966  THR   C N     1 
ATOM   5980 C CA    . THR   A 1 966  ? 178.701 143.220 147.608 1.00 46.07  ?  966  THR   C CA    1 
ATOM   5981 C C     . THR   A 1 966  ? 179.507 144.221 146.785 1.00 46.36  ?  966  THR   C C     1 
ATOM   5982 O O     . THR   A 1 966  ? 180.654 144.513 147.124 1.00 47.60  ?  966  THR   C O     1 
ATOM   5983 C CB    . THR   A 1 966  ? 179.555 141.959 147.813 1.00 50.39  ?  966  THR   C CB    1 
ATOM   5984 O OG1   . THR   A 1 966  ? 179.814 141.341 146.546 1.00 47.18  ?  966  THR   C OG1   1 
ATOM   5985 C CG2   . THR   A 1 966  ? 178.827 140.978 148.701 1.00 55.42  ?  966  THR   C CG2   1 
ATOM   5986 N N     . SER   A 1 967  ? 178.942 144.723 145.689 1.00 44.69  ?  967  SER   C N     1 
ATOM   5987 C CA    . SER   A 1 967  ? 179.706 145.619 144.822 1.00 46.07  ?  967  SER   C CA    1 
ATOM   5988 C C     . SER   A 1 967  ? 179.000 146.932 144.501 1.00 47.26  ?  967  SER   C C     1 
ATOM   5989 O O     . SER   A 1 967  ? 179.656 147.961 144.321 1.00 45.95  ?  967  SER   C O     1 
ATOM   5990 C CB    . SER   A 1 967  ? 180.037 144.917 143.529 1.00 49.21  ?  967  SER   C CB    1 
ATOM   5991 O OG    . SER   A 1 967  ? 178.874 144.563 142.861 1.00 47.07  ?  967  SER   C OG    1 
ATOM   5992 N N     . SER   A 1 968  ? 177.674 146.908 144.412 1.00 46.43  ?  968  SER   C N     1 
ATOM   5993 C CA    . SER   A 1 968  ? 176.931 148.116 144.083 1.00 43.24  ?  968  SER   C CA    1 
ATOM   5994 C C     . SER   A 1 968  ? 177.065 149.127 145.201 1.00 41.55  ?  968  SER   C C     1 
ATOM   5995 O O     . SER   A 1 968  ? 177.067 148.765 146.375 1.00 44.40  ?  968  SER   C O     1 
ATOM   5996 C CB    . SER   A 1 968  ? 175.473 147.800 143.840 1.00 40.14  ?  968  SER   C CB    1 
ATOM   5997 O OG    . SER   A 1 968  ? 174.732 148.972 143.627 1.00 36.81  ?  968  SER   C OG    1 
ATOM   5998 N N     . GLN   A 1 969  ? 177.188 150.396 144.842 1.00 38.75  ?  969  GLN   C N     1 
ATOM   5999 C CA    . GLN   A 1 969  ? 177.328 151.430 145.852 1.00 37.73  ?  969  GLN   C CA    1 
ATOM   6000 C C     . GLN   A 1 969  ? 176.030 152.190 146.074 1.00 38.19  ?  969  GLN   C C     1 
ATOM   6001 O O     . GLN   A 1 969  ? 175.805 152.739 147.153 1.00 38.66  ?  969  GLN   C O     1 
ATOM   6002 C CB    . GLN   A 1 969  ? 178.442 152.392 145.453 1.00 39.61  ?  969  GLN   C CB    1 
ATOM   6003 C CG    . GLN   A 1 969  ? 179.784 151.712 145.287 1.00 49.24  ?  969  GLN   C CG    1 
ATOM   6004 C CD    . GLN   A 1 969  ? 180.260 151.074 146.574 1.00 53.81  ?  969  GLN   C CD    1 
ATOM   6005 O OE1   . GLN   A 1 969  ? 180.428 151.755 147.590 1.00 51.05  ?  969  GLN   C OE1   1 
ATOM   6006 N NE2   . GLN   A 1 969  ? 180.471 149.763 146.546 1.00 52.79  ?  969  GLN   C NE2   1 
ATOM   6007 N N     . SER   A 1 970  ? 175.188 152.240 145.046 1.00 35.03  ?  970  SER   C N     1 
ATOM   6008 C CA    . SER   A 1 970  ? 173.952 153.010 145.103 1.00 31.61  ?  970  SER   C CA    1 
ATOM   6009 C C     . SER   A 1 970  ? 172.739 152.177 145.490 1.00 27.81  ?  970  SER   C C     1 
ATOM   6010 O O     . SER   A 1 970  ? 171.752 152.711 145.990 1.00 28.05  ?  970  SER   C O     1 
ATOM   6011 C CB    . SER   A 1 970  ? 173.704 153.662 143.762 1.00 27.56  ?  970  SER   C CB    1 
ATOM   6012 O OG    . SER   A 1 970  ? 173.520 152.697 142.760 1.00 27.86  ?  970  SER   C OG    1 
ATOM   6013 N N     . LEU   A 1 971  ? 172.800 150.871 145.271 1.00 27.16  ?  971  LEU   C N     1 
ATOM   6014 C CA    . LEU   A 1 971  ? 171.633 150.038 145.526 1.00 24.40  ?  971  LEU   C CA    1 
ATOM   6015 C C     . LEU   A 1 971  ? 171.233 150.107 146.991 1.00 25.96  ?  971  LEU   C C     1 
ATOM   6016 O O     . LEU   A 1 971  ? 172.069 149.958 147.882 1.00 30.71  ?  971  LEU   C O     1 
ATOM   6017 C CB    . LEU   A 1 971  ? 171.931 148.587 145.122 1.00 26.81  ?  971  LEU   C CB    1 
ATOM   6018 C CG    . LEU   A 1 971  ? 170.774 147.560 145.215 1.00 27.38  ?  971  LEU   C CG    1 
ATOM   6019 C CD1   . LEU   A 1 971  ? 169.705 147.876 144.173 1.00 21.78  ?  971  LEU   C CD1   1 
ATOM   6020 C CD2   . LEU   A 1 971  ? 171.347 146.163 144.985 1.00 34.60  ?  971  LEU   C CD2   1 
ATOM   6021 N N     . ARG   A 1 972  ? 169.952 150.346 147.238 1.00 23.29  ?  972  ARG   C N     1 
ATOM   6022 C CA    . ARG   A 1 972  ? 169.441 150.409 148.597 1.00 23.32  ?  972  ARG   C CA    1 
ATOM   6023 C C     . ARG   A 1 972  ? 168.332 149.404 148.814 1.00 25.20  ?  972  ARG   C C     1 
ATOM   6024 O O     . ARG   A 1 972  ? 168.175 148.885 149.921 1.00 29.54  ?  972  ARG   C O     1 
ATOM   6025 C CB    . ARG   A 1 972  ? 168.934 151.801 148.926 1.00 24.31  ?  972  ARG   C CB    1 
ATOM   6026 C CG    . ARG   A 1 972  ? 169.998 152.879 148.925 1.00 27.18  ?  972  ARG   C CG    1 
ATOM   6027 C CD    . ARG   A 1 972  ? 170.973 152.705 150.034 1.00 29.35  ?  972  ARG   C CD    1 
ATOM   6028 N NE    . ARG   A 1 972  ? 171.992 153.731 150.017 1.00 34.02  ?  972  ARG   C NE    1 
ATOM   6029 C CZ    . ARG   A 1 972  ? 173.158 153.649 149.340 1.00 38.57  ?  972  ARG   C CZ    1 
ATOM   6030 N NH1   . ARG   A 1 972  ? 173.448 152.586 148.625 1.00 34.16  1  972  ARG   C NH1   1 
ATOM   6031 N NH2   . ARG   A 1 972  ? 174.023 154.650 149.392 1.00 40.71  ?  972  ARG   C NH2   1 
ATOM   6032 N N     . LYS   A 1 973  ? 167.568 149.130 147.764 1.00 21.35  ?  973  LYS   C N     1 
ATOM   6033 C CA    . LYS   A 1 973  ? 166.467 148.186 147.857 1.00 22.12  ?  973  LYS   C CA    1 
ATOM   6034 C C     . LYS   A 1 973  ? 166.513 147.190 146.711 1.00 20.67  ?  973  LYS   C C     1 
ATOM   6035 O O     . LYS   A 1 973  ? 166.512 147.577 145.542 1.00 21.26  ?  973  LYS   C O     1 
ATOM   6036 C CB    . LYS   A 1 973  ? 165.131 148.922 147.830 1.00 20.89  ?  973  LYS   C CB    1 
ATOM   6037 C CG    . LYS   A 1 973  ? 163.907 148.039 148.071 1.00 24.44  ?  973  LYS   C CG    1 
ATOM   6038 C CD    . LYS   A 1 973  ? 162.600 148.824 147.916 1.00 24.34  ?  973  LYS   C CD    1 
ATOM   6039 C CE    . LYS   A 1 973  ? 162.320 149.724 149.110 1.00 26.18  ?  973  LYS   C CE    1 
ATOM   6040 N NZ    . LYS   A 1 973  ? 161.019 150.430 148.971 1.00 28.06  1  973  LYS   C NZ    1 
ATOM   6041 N N     . LEU   A 1 974  ? 166.543 145.911 147.047 1.00 21.10  ?  974  LEU   C N     1 
ATOM   6042 C CA    . LEU   A 1 974  ? 166.520 144.853 146.051 1.00 19.61  ?  974  LEU   C CA    1 
ATOM   6043 C C     . LEU   A 1 974  ? 165.412 143.900 146.405 1.00 19.88  ?  974  LEU   C C     1 
ATOM   6044 O O     . LEU   A 1 974  ? 165.411 143.342 147.496 1.00 28.63  ?  974  LEU   C O     1 
ATOM   6045 C CB    . LEU   A 1 974  ? 167.853 144.100 146.012 1.00 23.67  ?  974  LEU   C CB    1 
ATOM   6046 C CG    . LEU   A 1 974  ? 167.938 142.899 145.033 1.00 23.35  ?  974  LEU   C CG    1 
ATOM   6047 C CD1   . LEU   A 1 974  ? 167.787 143.389 143.602 1.00 21.95  ?  974  LEU   C CD1   1 
ATOM   6048 C CD2   . LEU   A 1 974  ? 169.275 142.205 145.217 1.00 31.57  ?  974  LEU   C CD2   1 
ATOM   6049 N N     . SER   A 1 975  ? 164.465 143.715 145.504 1.00 18.01  ?  975  SER   C N     1 
ATOM   6050 C CA    . SER   A 1 975  ? 163.321 142.892 145.843 1.00 19.63  ?  975  SER   C CA    1 
ATOM   6051 C C     . SER   A 1 975  ? 163.160 141.675 144.955 1.00 21.88  ?  975  SER   C C     1 
ATOM   6052 O O     . SER   A 1 975  ? 162.855 141.780 143.767 1.00 20.52  ?  975  SER   C O     1 
ATOM   6053 C CB    . SER   A 1 975  ? 162.060 143.723 145.798 1.00 21.63  ?  975  SER   C CB    1 
ATOM   6054 O OG    . SER   A 1 975  ? 160.927 142.928 146.008 1.00 24.30  ?  975  SER   C OG    1 
ATOM   6055 N N     . LEU   A 1 976  ? 163.342 140.509 145.560 1.00 25.19  ?  976  LEU   C N     1 
ATOM   6056 C CA    . LEU   A 1 976  ? 163.123 139.233 144.893 1.00 19.23  ?  976  LEU   C CA    1 
ATOM   6057 C C     . LEU   A 1 976  ? 161.793 138.714 145.410 1.00 22.90  ?  976  LEU   C C     1 
ATOM   6058 O O     . LEU   A 1 976  ? 161.381 139.101 146.501 1.00 28.78  ?  976  LEU   C O     1 
ATOM   6059 C CB    . LEU   A 1 976  ? 164.260 138.267 145.211 1.00 22.24  ?  976  LEU   C CB    1 
ATOM   6060 C CG    . LEU   A 1 976  ? 165.680 138.786 144.906 1.00 22.64  ?  976  LEU   C CG    1 
ATOM   6061 C CD1   . LEU   A 1 976  ? 166.690 137.767 145.376 1.00 38.51  ?  976  LEU   C CD1   1 
ATOM   6062 C CD2   . LEU   A 1 976  ? 165.828 139.047 143.416 1.00 24.33  ?  976  LEU   C CD2   1 
ATOM   6063 N N     . GLY   A 1 977  ? 161.092 137.880 144.654 1.00 22.53  ?  977  GLY   C N     1 
ATOM   6064 C CA    . GLY   A 1 977  ? 159.772 137.460 145.127 1.00 23.93  ?  977  GLY   C CA    1 
ATOM   6065 C C     . GLY   A 1 977  ? 159.361 136.059 144.706 1.00 27.36  ?  977  GLY   C C     1 
ATOM   6066 O O     . GLY   A 1 977  ? 159.969 135.068 145.096 1.00 34.24  ?  977  GLY   C O     1 
ATOM   6067 N N     . ASN   A 1 978  ? 158.296 135.971 143.931 1.00 25.82  ?  978  ASN   C N     1 
ATOM   6068 C CA    . ASN   A 1 978  ? 157.716 134.681 143.594 1.00 25.52  ?  978  ASN   C CA    1 
ATOM   6069 C C     . ASN   A 1 978  ? 158.537 133.923 142.561 1.00 28.80  ?  978  ASN   C C     1 
ATOM   6070 O O     . ASN   A 1 978  ? 158.142 133.787 141.404 1.00 30.93  ?  978  ASN   C O     1 
ATOM   6071 C CB    . ASN   A 1 978  ? 156.296 134.867 143.108 1.00 24.97  ?  978  ASN   C CB    1 
ATOM   6072 C CG    . ASN   A 1 978  ? 155.563 133.578 142.969 1.00 40.69  ?  978  ASN   C CG    1 
ATOM   6073 O OD1   . ASN   A 1 978  ? 156.076 132.512 143.331 1.00 50.23  ?  978  ASN   C OD1   1 
ATOM   6074 N ND2   . ASN   A 1 978  ? 154.362 133.645 142.452 1.00 46.40  ?  978  ASN   C ND2   1 
ATOM   6075 N N     . ASN   A 1 979  ? 159.679 133.417 142.995 1.00 32.06  ?  979  ASN   C N     1 
ATOM   6076 C CA    . ASN   A 1 979  ? 160.561 132.645 142.137 1.00 36.51  ?  979  ASN   C CA    1 
ATOM   6077 C C     . ASN   A 1 979  ? 161.339 131.615 142.962 1.00 41.14  ?  979  ASN   C C     1 
ATOM   6078 O O     . ASN   A 1 979  ? 161.496 131.764 144.175 1.00 40.85  ?  979  ASN   C O     1 
ATOM   6079 C CB    . ASN   A 1 979  ? 161.465 133.573 141.348 1.00 32.91  ?  979  ASN   C CB    1 
ATOM   6080 C CG    . ASN   A 1 979  ? 162.369 134.382 142.208 1.00 35.56  ?  979  ASN   C CG    1 
ATOM   6081 O OD1   . ASN   A 1 979  ? 161.982 135.417 142.769 1.00 30.16  ?  979  ASN   C OD1   1 
ATOM   6082 N ND2   . ASN   A 1 979  ? 163.586 133.932 142.314 1.00 42.42  ?  979  ASN   C ND2   1 
ATOM   6083 N N     . ASP   A 1 980  ? 161.816 130.555 142.311 1.00 43.08  ?  980  ASP   C N     1 
ATOM   6084 C CA    . ASP   A 1 980  ? 162.481 129.472 143.033 1.00 45.17  ?  980  ASP   C CA    1 
ATOM   6085 C C     . ASP   A 1 980  ? 163.948 129.769 143.304 1.00 44.30  ?  980  ASP   C C     1 
ATOM   6086 O O     . ASP   A 1 980  ? 164.842 129.171 142.704 1.00 47.28  ?  980  ASP   C O     1 
ATOM   6087 C CB    . ASP   A 1 980  ? 162.352 128.153 142.268 1.00 53.28  ?  980  ASP   C CB    1 
ATOM   6088 C CG    . ASP   A 1 980  ? 162.787 126.942 143.101 1.00 64.02  ?  980  ASP   C CG    1 
ATOM   6089 O OD1   . ASP   A 1 980  ? 162.896 127.083 144.300 1.00 64.89  ?  980  ASP   C OD1   1 
ATOM   6090 O OD2   . ASP   A 1 980  ? 162.989 125.891 142.536 1.00 57.55  -1 980  ASP   C OD2   1 
ATOM   6091 N N     . LEU   A 1 981  ? 164.177 130.696 144.223 1.00 45.29  ?  981  LEU   C N     1 
ATOM   6092 C CA    . LEU   A 1 981  ? 165.520 131.141 144.584 1.00 46.14  ?  981  LEU   C CA    1 
ATOM   6093 C C     . LEU   A 1 981  ? 166.314 130.025 145.264 1.00 50.03  ?  981  LEU   C C     1 
ATOM   6094 O O     . LEU   A 1 981  ? 167.525 129.907 145.081 1.00 50.67  ?  981  LEU   C O     1 
ATOM   6095 C CB    . LEU   A 1 981  ? 165.432 132.343 145.529 1.00 49.68  ?  981  LEU   C CB    1 
ATOM   6096 C CG    . LEU   A 1 981  ? 166.750 133.055 145.859 1.00 49.38  ?  981  LEU   C CG    1 
ATOM   6097 C CD1   . LEU   A 1 981  ? 167.325 133.686 144.595 1.00 45.79  ?  981  LEU   C CD1   1 
ATOM   6098 C CD2   . LEU   A 1 981  ? 166.495 134.098 146.921 1.00 47.28  ?  981  LEU   C CD2   1 
ATOM   6099 N N     . GLY   A 1 982  ? 165.629 129.227 146.078 1.00 50.72  ?  982  GLY   C N     1 
ATOM   6100 C CA    . GLY   A 1 982  ? 166.250 128.098 146.764 1.00 52.25  ?  982  GLY   C CA    1 
ATOM   6101 C C     . GLY   A 1 982  ? 166.861 128.471 148.110 1.00 52.68  ?  982  GLY   C C     1 
ATOM   6102 O O     . GLY   A 1 982  ? 167.046 129.650 148.426 1.00 52.52  ?  982  GLY   C O     1 
ATOM   6103 N N     . ASP   A 1 983  ? 167.217 127.446 148.883 1.00 52.57  ?  983  ASP   C N     1 
ATOM   6104 C CA    . ASP   A 1 983  ? 167.802 127.636 150.203 1.00 54.66  ?  983  ASP   C CA    1 
ATOM   6105 C C     . ASP   A 1 983  ? 169.273 127.979 150.089 1.00 57.50  ?  983  ASP   C C     1 
ATOM   6106 O O     . ASP   A 1 983  ? 169.805 128.752 150.883 1.00 57.46  ?  983  ASP   C O     1 
ATOM   6107 C CB    . ASP   A 1 983  ? 167.671 126.359 151.033 1.00 61.44  ?  983  ASP   C CB    1 
ATOM   6108 C CG    . ASP   A 1 983  ? 166.249 125.983 151.388 1.00 65.25  ?  983  ASP   C CG    1 
ATOM   6109 O OD1   . ASP   A 1 983  ? 165.700 125.133 150.732 1.00 67.19  ?  983  ASP   C OD1   1 
ATOM   6110 O OD2   . ASP   A 1 983  ? 165.732 126.526 152.331 1.00 61.24  -1 983  ASP   C OD2   1 
ATOM   6111 N N     . LEU   A 1 984  ? 169.933 127.417 149.085 1.00 50.41  ?  984  LEU   C N     1 
ATOM   6112 C CA    . LEU   A 1 984  ? 171.351 127.677 148.903 1.00 52.26  ?  984  LEU   C CA    1 
ATOM   6113 C C     . LEU   A 1 984  ? 171.542 129.143 148.556 1.00 54.94  ?  984  LEU   C C     1 
ATOM   6114 O O     . LEU   A 1 984  ? 172.498 129.784 148.996 1.00 58.40  ?  984  LEU   C O     1 
ATOM   6115 C CB    . LEU   A 1 984  ? 171.918 126.798 147.782 1.00 54.91  ?  984  LEU   C CB    1 
ATOM   6116 C CG    . LEU   A 1 984  ? 171.954 125.269 148.047 1.00 76.34  ?  984  LEU   C CG    1 
ATOM   6117 C CD1   . LEU   A 1 984  ? 172.342 124.551 146.757 1.00 53.66  ?  984  LEU   C CD1   1 
ATOM   6118 C CD2   . LEU   A 1 984  ? 172.956 124.958 149.153 1.00 66.43  ?  984  LEU   C CD2   1 
ATOM   6119 N N     . GLY   A 1 985  ? 170.608 129.668 147.771 1.00 54.37  ?  985  GLY   C N     1 
ATOM   6120 C CA    . GLY   A 1 985  ? 170.636 131.055 147.341 1.00 50.12  ?  985  GLY   C CA    1 
ATOM   6121 C C     . GLY   A 1 985  ? 170.555 132.005 148.522 1.00 53.32  ?  985  GLY   C C     1 
ATOM   6122 O O     . GLY   A 1 985  ? 171.422 132.863 148.699 1.00 54.50  ?  985  GLY   C O     1 
ATOM   6123 N N     . VAL   A 1 986  ? 169.527 131.841 149.345 1.00 49.22  ?  986  VAL   C N     1 
ATOM   6124 C CA    . VAL   A 1 986  ? 169.353 132.729 150.481 1.00 51.53  ?  986  VAL   C CA    1 
ATOM   6125 C C     . VAL   A 1 986  ? 170.497 132.633 151.472 1.00 56.80  ?  986  VAL   C C     1 
ATOM   6126 O O     . VAL   A 1 986  ? 170.934 133.654 152.008 1.00 57.84  ?  986  VAL   C O     1 
ATOM   6127 C CB    . VAL   A 1 986  ? 168.032 132.451 151.204 1.00 51.80  ?  986  VAL   C CB    1 
ATOM   6128 C CG1   . VAL   A 1 986  ? 167.980 133.231 152.498 1.00 54.64  ?  986  VAL   C CG1   1 
ATOM   6129 C CG2   . VAL   A 1 986  ? 166.899 132.853 150.320 1.00 46.75  ?  986  VAL   C CG2   1 
ATOM   6130 N N     . MET   A 1 987  ? 170.967 131.420 151.747 1.00 58.66  ?  987  MET   C N     1 
ATOM   6131 C CA    . MET   A 1 987  ? 172.057 131.276 152.699 1.00 60.12  ?  987  MET   C CA    1 
ATOM   6132 C C     . MET   A 1 987  ? 173.291 132.017 152.206 1.00 59.02  ?  987  MET   C C     1 
ATOM   6133 O O     . MET   A 1 987  ? 173.958 132.700 152.984 1.00 64.46  ?  987  MET   C O     1 
ATOM   6134 C CB    . MET   A 1 987  ? 172.370 129.803 152.944 1.00 64.99  ?  987  MET   C CB    1 
ATOM   6135 C CG    . MET   A 1 987  ? 171.298 129.049 153.734 1.00 68.22  ?  987  MET   C CG    1 
ATOM   6136 S SD    . MET   A 1 987  ? 171.025 129.711 155.394 1.00 73.39  ?  987  MET   C SD    1 
ATOM   6137 C CE    . MET   A 1 987  ? 172.525 129.231 156.240 1.00 72.65  ?  987  MET   C CE    1 
ATOM   6138 N N     . MET   A 1 988  ? 173.577 131.919 150.909 1.00 57.60  ?  988  MET   C N     1 
ATOM   6139 C CA    . MET   A 1 988  ? 174.720 132.626 150.356 1.00 61.81  ?  988  MET   C CA    1 
ATOM   6140 C C     . MET   A 1 988  ? 174.561 134.129 150.523 1.00 60.28  ?  988  MET   C C     1 
ATOM   6141 O O     . MET   A 1 988  ? 175.524 134.822 150.850 1.00 60.18  ?  988  MET   C O     1 
ATOM   6142 C CB    . MET   A 1 988  ? 174.928 132.267 148.890 1.00 56.96  ?  988  MET   C CB    1 
ATOM   6143 C CG    . MET   A 1 988  ? 176.118 132.979 148.240 1.00 58.87  ?  988  MET   C CG    1 
ATOM   6144 S SD    . MET   A 1 988  ? 176.562 132.300 146.625 1.00 68.25  ?  988  MET   C SD    1 
ATOM   6145 C CE    . MET   A 1 988  ? 175.132 132.711 145.659 1.00 59.61  ?  988  MET   C CE    1 
ATOM   6146 N N     . PHE   A 1 989  ? 173.344 134.638 150.323 1.00 57.76  ?  989  PHE   C N     1 
ATOM   6147 C CA    . PHE   A 1 989  ? 173.108 136.068 150.504 1.00 60.28  ?  989  PHE   C CA    1 
ATOM   6148 C C     . PHE   A 1 989  ? 173.346 136.469 151.952 1.00 57.75  ?  989  PHE   C C     1 
ATOM   6149 O O     . PHE   A 1 989  ? 174.003 137.472 152.232 1.00 59.95  ?  989  PHE   C O     1 
ATOM   6150 C CB    . PHE   A 1 989  ? 171.674 136.449 150.132 1.00 55.70  ?  989  PHE   C CB    1 
ATOM   6151 C CG    . PHE   A 1 989  ? 171.324 136.352 148.666 1.00 55.62  ?  989  PHE   C CG    1 
ATOM   6152 C CD1   . PHE   A 1 989  ? 172.290 136.223 147.668 1.00 54.46  ?  989  PHE   C CD1   1 
ATOM   6153 C CD2   . PHE   A 1 989  ? 169.996 136.395 148.285 1.00 51.64  ?  989  PHE   C CD2   1 
ATOM   6154 C CE1   . PHE   A 1 989  ? 171.919 136.135 146.349 1.00 51.84  ?  989  PHE   C CE1   1 
ATOM   6155 C CE2   . PHE   A 1 989  ? 169.636 136.309 146.967 1.00 49.56  ?  989  PHE   C CE2   1 
ATOM   6156 C CZ    . PHE   A 1 989  ? 170.594 136.175 145.999 1.00 51.01  ?  989  PHE   C CZ    1 
ATOM   6157 N N     . CYS   A 1 990  ? 172.851 135.664 152.881 1.00 60.75  ?  990  CYS   C N     1 
ATOM   6158 C CA    . CYS   A 1 990  ? 172.991 135.979 154.297 1.00 62.71  ?  990  CYS   C CA    1 
ATOM   6159 C C     . CYS   A 1 990  ? 174.454 136.124 154.691 1.00 65.44  ?  990  CYS   C C     1 
ATOM   6160 O O     . CYS   A 1 990  ? 174.806 136.966 155.517 1.00 67.36  ?  990  CYS   C O     1 
ATOM   6161 C CB    . CYS   A 1 990  ? 172.354 134.887 155.151 1.00 63.13  ?  990  CYS   C CB    1 
ATOM   6162 S SG    . CYS   A 1 990  ? 170.565 134.781 154.995 1.00 65.13  ?  990  CYS   C SG    1 
ATOM   6163 N N     . GLU   A 1 991  ? 175.308 135.307 154.085 1.00 64.39  ?  991  GLU   C N     1 
ATOM   6164 C CA    . GLU   A 1 991  ? 176.735 135.312 154.377 1.00 65.89  ?  991  GLU   C CA    1 
ATOM   6165 C C     . GLU   A 1 991  ? 177.458 136.551 153.858 1.00 65.22  ?  991  GLU   C C     1 
ATOM   6166 O O     . GLU   A 1 991  ? 178.573 136.844 154.292 1.00 65.56  ?  991  GLU   C O     1 
ATOM   6167 C CB    . GLU   A 1 991  ? 177.395 134.064 153.788 1.00 69.38  ?  991  GLU   C CB    1 
ATOM   6168 C CG    . GLU   A 1 991  ? 177.002 132.756 154.471 1.00 72.76  ?  991  GLU   C CG    1 
ATOM   6169 C CD    . GLU   A 1 991  ? 177.638 131.550 153.834 1.00 80.96  ?  991  GLU   C CD    1 
ATOM   6170 O OE1   . GLU   A 1 991  ? 178.323 131.713 152.852 1.00 76.82  ?  991  GLU   C OE1   1 
ATOM   6171 O OE2   . GLU   A 1 991  ? 177.437 130.466 154.328 1.00 81.86  -1 991  GLU   C OE2   1 
ATOM   6172 N N     . VAL   A 1 992  ? 176.856 137.258 152.906 1.00 64.48  ?  992  VAL   C N     1 
ATOM   6173 C CA    . VAL   A 1 992  ? 177.520 138.411 152.313 1.00 65.19  ?  992  VAL   C CA    1 
ATOM   6174 C C     . VAL   A 1 992  ? 176.859 139.726 152.711 1.00 63.53  ?  992  VAL   C C     1 
ATOM   6175 O O     . VAL   A 1 992  ? 177.491 140.779 152.665 1.00 63.58  ?  992  VAL   C O     1 
ATOM   6176 C CB    . VAL   A 1 992  ? 177.567 138.282 150.778 1.00 64.75  ?  992  VAL   C CB    1 
ATOM   6177 C CG1   . VAL   A 1 992  ? 178.377 137.052 150.387 1.00 67.17  ?  992  VAL   C CG1   1 
ATOM   6178 C CG2   . VAL   A 1 992  ? 176.165 138.182 150.218 1.00 60.56  ?  992  VAL   C CG2   1 
ATOM   6179 N N     . LEU   A 1 993  ? 175.609 139.658 153.162 1.00 62.89  ?  993  LEU   C N     1 
ATOM   6180 C CA    . LEU   A 1 993  ? 174.871 140.843 153.595 1.00 63.50  ?  993  LEU   C CA    1 
ATOM   6181 C C     . LEU   A 1 993  ? 175.428 141.396 154.896 1.00 64.93  ?  993  LEU   C C     1 
ATOM   6182 O O     . LEU   A 1 993  ? 175.056 142.484 155.333 1.00 65.63  ?  993  LEU   C O     1 
ATOM   6183 C CB    . LEU   A 1 993  ? 173.382 140.512 153.763 1.00 61.91  ?  993  LEU   C CB    1 
ATOM   6184 C CG    . LEU   A 1 993  ? 172.584 140.276 152.459 1.00 62.62  ?  993  LEU   C CG    1 
ATOM   6185 C CD1   . LEU   A 1 993  ? 171.243 139.661 152.791 1.00 59.97  ?  993  LEU   C CD1   1 
ATOM   6186 C CD2   . LEU   A 1 993  ? 172.376 141.601 151.743 1.00 54.13  ?  993  LEU   C CD2   1 
ATOM   6187 N N     . LYS   A 1 994  ? 176.319 140.633 155.512 1.00 68.05  ?  994  LYS   C N     1 
ATOM   6188 C CA    . LYS   A 1 994  ? 176.962 141.024 156.753 1.00 70.72  ?  994  LYS   C CA    1 
ATOM   6189 C C     . LYS   A 1 994  ? 178.226 141.845 156.511 1.00 72.12  ?  994  LYS   C C     1 
ATOM   6190 O O     . LYS   A 1 994  ? 178.735 142.499 157.424 1.00 74.24  ?  994  LYS   C O     1 
ATOM   6191 C CB    . LYS   A 1 994  ? 177.317 139.779 157.563 1.00 71.67  ?  994  LYS   C CB    1 
ATOM   6192 C CG    . LYS   A 1 994  ? 176.126 139.007 158.081 1.00 73.27  ?  994  LYS   C CG    1 
ATOM   6193 C CD    . LYS   A 1 994  ? 176.562 137.788 158.867 1.00 77.03  ?  994  LYS   C CD    1 
ATOM   6194 C CE    . LYS   A 1 994  ? 175.368 137.056 159.459 1.00 82.40  ?  994  LYS   C CE    1 
ATOM   6195 N NZ    . LYS   A 1 994  ? 175.787 135.871 160.260 1.00 79.55  1  994  LYS   C NZ    1 
ATOM   6196 N N     . GLN   A 1 995  ? 178.759 141.786 155.293 1.00 71.51  ?  995  GLN   C N     1 
ATOM   6197 C CA    . GLN   A 1 995  ? 180.052 142.394 155.004 1.00 73.15  ?  995  GLN   C CA    1 
ATOM   6198 C C     . GLN   A 1 995  ? 179.934 143.851 154.578 1.00 73.31  ?  995  GLN   C C     1 
ATOM   6199 O O     . GLN   A 1 995  ? 180.247 144.204 153.442 1.00 72.70  ?  995  GLN   C O     1 
ATOM   6200 C CB    . GLN   A 1 995  ? 180.769 141.591 153.919 1.00 72.88  ?  995  GLN   C CB    1 
ATOM   6201 C CG    . GLN   A 1 995  ? 181.008 140.140 154.291 1.00 73.65  ?  995  GLN   C CG    1 
ATOM   6202 C CD    . GLN   A 1 995  ? 181.922 140.006 155.483 1.00 78.96  ?  995  GLN   C CD    1 
ATOM   6203 O OE1   . GLN   A 1 995  ? 183.078 140.433 155.440 1.00 76.92  ?  995  GLN   C OE1   1 
ATOM   6204 N NE2   . GLN   A 1 995  ? 181.415 139.416 156.559 1.00 80.60  ?  995  GLN   C NE2   1 
ATOM   6205 N N     . GLN   A 1 996  ? 179.487 144.693 155.504 1.00 70.00  ?  996  GLN   C N     1 
ATOM   6206 C CA    . GLN   A 1 996  ? 179.328 146.127 155.255 1.00 70.40  ?  996  GLN   C CA    1 
ATOM   6207 C C     . GLN   A 1 996  ? 178.545 146.418 153.980 1.00 65.70  ?  996  GLN   C C     1 
ATOM   6208 O O     . GLN   A 1 996  ? 178.939 147.273 153.185 1.00 63.38  ?  996  GLN   C O     1 
ATOM   6209 C CB    . GLN   A 1 996  ? 180.693 146.823 155.171 1.00 71.10  ?  996  GLN   C CB    1 
ATOM   6210 C CG    . GLN   A 1 996  ? 181.478 146.831 156.467 1.00 69.94  ?  996  GLN   C CG    1 
ATOM   6211 C CD    . GLN   A 1 996  ? 180.860 147.753 157.497 1.00 67.15  ?  996  GLN   C CD    1 
ATOM   6212 O OE1   . GLN   A 1 996  ? 180.766 148.964 157.290 1.00 64.89  ?  996  GLN   C OE1   1 
ATOM   6213 N NE2   . GLN   A 1 996  ? 180.433 147.186 158.615 1.00 66.68  ?  996  GLN   C NE2   1 
ATOM   6214 N N     . SER   A 1 997  ? 177.435 145.719 153.788 1.00 63.66  ?  997  SER   C N     1 
ATOM   6215 C CA    . SER   A 1 997  ? 176.594 145.945 152.622 1.00 58.10  ?  997  SER   C CA    1 
ATOM   6216 C C     . SER   A 1 997  ? 175.887 147.282 152.723 1.00 49.57  ?  997  SER   C C     1 
ATOM   6217 O O     . SER   A 1 997  ? 175.508 147.712 153.812 1.00 48.25  ?  997  SER   C O     1 
ATOM   6218 C CB    . SER   A 1 997  ? 175.574 144.839 152.469 1.00 57.38  ?  997  SER   C CB    1 
ATOM   6219 O OG    . SER   A 1 997  ? 174.689 145.124 151.418 1.00 51.46  ?  997  SER   C OG    1 
ATOM   6220 N N     . CYS   A 1 998  ? 175.693 147.938 151.587 1.00 48.25  ?  998  CYS   C N     1 
ATOM   6221 C CA    . CYS   A 1 998  ? 174.984 149.206 151.569 1.00 42.88  ?  998  CYS   C CA    1 
ATOM   6222 C C     . CYS   A 1 998  ? 173.479 149.002 151.491 1.00 40.53  ?  998  CYS   C C     1 
ATOM   6223 O O     . CYS   A 1 998  ? 172.717 149.961 151.572 1.00 37.19  ?  998  CYS   C O     1 
ATOM   6224 C CB    . CYS   A 1 998  ? 175.435 150.064 150.391 1.00 46.15  ?  998  CYS   C CB    1 
ATOM   6225 S SG    . CYS   A 1 998  ? 174.946 149.420 148.774 1.00 50.22  ?  998  CYS   C SG    1 
ATOM   6226 N N     . LEU   A 1 999  ? 173.048 147.760 151.295 1.00 38.82  ?  999  LEU   C N     1 
ATOM   6227 C CA    . LEU   A 1 999  ? 171.622 147.487 151.189 1.00 33.60  ?  999  LEU   C CA    1 
ATOM   6228 C C     . LEU   A 1 999  ? 170.961 147.828 152.515 1.00 35.78  ?  999  LEU   C C     1 
ATOM   6229 O O     . LEU   A 1 999  ? 171.423 147.386 153.565 1.00 44.06  ?  999  LEU   C O     1 
ATOM   6230 C CB    . LEU   A 1 999  ? 171.373 146.007 150.871 1.00 32.62  ?  999  LEU   C CB    1 
ATOM   6231 C CG    . LEU   A 1 999  ? 169.951 145.650 150.415 1.00 32.33  ?  999  LEU   C CG    1 
ATOM   6232 C CD1   . LEU   A 1 999  ? 169.737 146.160 148.987 1.00 33.70  ?  999  LEU   C CD1   1 
ATOM   6233 C CD2   . LEU   A 1 999  ? 169.743 144.161 150.498 1.00 36.56  ?  999  LEU   C CD2   1 
ATOM   6234 N N     . LEU   A 1 1000 ? 169.889 148.612 152.478 1.00 35.31  ?  1000 LEU   C N     1 
ATOM   6235 C CA    . LEU   A 1 1000 ? 169.222 149.009 153.715 1.00 39.16  ?  1000 LEU   C CA    1 
ATOM   6236 C C     . LEU   A 1 1000 ? 167.771 148.570 153.772 1.00 38.36  ?  1000 LEU   C C     1 
ATOM   6237 O O     . LEU   A 1 1000 ? 167.195 148.448 154.851 1.00 45.37  ?  1000 LEU   C O     1 
ATOM   6238 C CB    . LEU   A 1 1000 ? 169.271 150.533 153.892 1.00 38.59  ?  1000 LEU   C CB    1 
ATOM   6239 C CG    . LEU   A 1 1000 ? 170.669 151.186 153.977 1.00 46.13  ?  1000 LEU   C CG    1 
ATOM   6240 C CD1   . LEU   A 1 1000 ? 170.509 152.698 154.059 1.00 46.39  ?  1000 LEU   C CD1   1 
ATOM   6241 C CD2   . LEU   A 1 1000 ? 171.420 150.663 155.196 1.00 55.83  ?  1000 LEU   C CD2   1 
ATOM   6242 N N     . GLN   A 1 1001 ? 167.151 148.437 152.616 1.00 32.46  ?  1001 GLN   C N     1 
ATOM   6243 C CA    . GLN   A 1 1001 ? 165.711 148.267 152.556 1.00 35.10  ?  1001 GLN   C CA    1 
ATOM   6244 C C     . GLN   A 1 1001 ? 165.266 146.852 152.266 1.00 32.47  ?  1001 GLN   C C     1 
ATOM   6245 O O     . GLN   A 1 1001 ? 166.074 145.934 152.135 1.00 31.48  ?  1001 GLN   C O     1 
ATOM   6246 C CB    . GLN   A 1 1001 ? 165.120 149.214 151.526 1.00 39.09  ?  1001 GLN   C CB    1 
ATOM   6247 C CG    . GLN   A 1 1001 ? 165.401 150.674 151.805 1.00 41.83  ?  1001 GLN   C CG    1 
ATOM   6248 C CD    . GLN   A 1 1001 ? 164.821 151.121 153.127 1.00 49.03  ?  1001 GLN   C CD    1 
ATOM   6249 O OE1   . GLN   A 1 1001 ? 163.660 150.837 153.435 1.00 40.99  ?  1001 GLN   C OE1   1 
ATOM   6250 N NE2   . GLN   A 1 1001 ? 165.620 151.820 153.917 1.00 45.83  ?  1001 GLN   C NE2   1 
ATOM   6251 N N     . ASN   A 1 1002 ? 163.953 146.691 152.206 1.00 35.11  ?  1002 ASN   C N     1 
ATOM   6252 C CA    . ASN   A 1 1002 ? 163.304 145.407 152.036 1.00 39.69  ?  1002 ASN   C CA    1 
ATOM   6253 C C     . ASN   A 1 1002 ? 164.002 144.546 150.992 1.00 36.54  ?  1002 ASN   C C     1 
ATOM   6254 O O     . ASN   A 1 1002 ? 164.040 144.885 149.810 1.00 35.26  ?  1002 ASN   C O     1 
ATOM   6255 C CB    . ASN   A 1 1002 ? 161.844 145.633 151.676 1.00 40.86  ?  1002 ASN   C CB    1 
ATOM   6256 C CG    . ASN   A 1 1002 ? 160.987 144.398 151.788 1.00 47.58  ?  1002 ASN   C CG    1 
ATOM   6257 O OD1   . ASN   A 1 1002 ? 161.477 143.264 151.775 1.00 45.12  ?  1002 ASN   C OD1   1 
ATOM   6258 N ND2   . ASN   A 1 1002 ? 159.694 144.607 151.899 1.00 54.06  ?  1002 ASN   C ND2   1 
ATOM   6259 N N     . LEU   A 1 1003 ? 164.521 143.408 151.447 1.00 35.20  ?  1003 LEU   C N     1 
ATOM   6260 C CA    . LEU   A 1 1003 ? 165.206 142.434 150.600 1.00 31.57  ?  1003 LEU   C CA    1 
ATOM   6261 C C     . LEU   A 1 1003 ? 164.213 141.599 149.791 1.00 31.81  ?  1003 LEU   C C     1 
ATOM   6262 O O     . LEU   A 1 1003 ? 164.581 140.908 148.837 1.00 31.79  ?  1003 LEU   C O     1 
ATOM   6263 C CB    . LEU   A 1 1003 ? 166.066 141.511 151.475 1.00 37.38  ?  1003 LEU   C CB    1 
ATOM   6264 C CG    . LEU   A 1 1003 ? 166.932 140.447 150.757 1.00 37.91  ?  1003 LEU   C CG    1 
ATOM   6265 C CD1   . LEU   A 1 1003 ? 167.924 141.113 149.816 1.00 35.88  ?  1003 LEU   C CD1   1 
ATOM   6266 C CD2   . LEU   A 1 1003 ? 167.660 139.628 151.815 1.00 45.34  ?  1003 LEU   C CD2   1 
ATOM   6267 N N     . GLY   A 1 1004 ? 162.954 141.646 150.195 1.00 33.01  ?  1004 GLY   C N     1 
ATOM   6268 C CA    . GLY   A 1 1004 ? 161.917 140.850 149.559 1.00 32.96  ?  1004 GLY   C CA    1 
ATOM   6269 C C     . GLY   A 1 1004 ? 161.959 139.408 150.033 1.00 33.54  ?  1004 GLY   C C     1 
ATOM   6270 O O     . GLY   A 1 1004 ? 161.911 139.137 151.228 1.00 38.34  ?  1004 GLY   C O     1 
ATOM   6271 N N     . LEU   A 1 1005 ? 162.018 138.482 149.090 1.00 30.67  ?  1005 LEU   C N     1 
ATOM   6272 C CA    . LEU   A 1 1005 ? 161.978 137.055 149.382 1.00 31.59  ?  1005 LEU   C CA    1 
ATOM   6273 C C     . LEU   A 1 1005 ? 160.606 136.663 149.902 1.00 32.98  ?  1005 LEU   C C     1 
ATOM   6274 O O     . LEU   A 1 1005 ? 160.464 135.669 150.616 1.00 37.10  ?  1005 LEU   C O     1 
ATOM   6275 C CB    . LEU   A 1 1005 ? 163.039 136.662 150.430 1.00 31.85  ?  1005 LEU   C CB    1 
ATOM   6276 C CG    . LEU   A 1 1005 ? 164.480 137.117 150.158 1.00 30.06  ?  1005 LEU   C CG    1 
ATOM   6277 C CD1   . LEU   A 1 1005 ? 165.355 136.734 151.340 1.00 40.30  ?  1005 LEU   C CD1   1 
ATOM   6278 C CD2   . LEU   A 1 1005 ? 164.984 136.468 148.897 1.00 32.02  ?  1005 LEU   C CD2   1 
ATOM   6279 N N     . SER   A 1 1006 ? 159.595 137.447 149.544 1.00 30.00  ?  1006 SER   C N     1 
ATOM   6280 C CA    . SER   A 1 1006 ? 158.232 137.126 149.919 1.00 34.13  ?  1006 SER   C CA    1 
ATOM   6281 C C     . SER   A 1 1006 ? 157.736 135.981 149.062 1.00 35.88  ?  1006 SER   C C     1 
ATOM   6282 O O     . SER   A 1 1006 ? 158.282 135.712 147.995 1.00 34.86  ?  1006 SER   C O     1 
ATOM   6283 C CB    . SER   A 1 1006 ? 157.332 138.330 149.748 1.00 36.85  ?  1006 SER   C CB    1 
ATOM   6284 O OG    . SER   A 1 1006 ? 157.181 138.652 148.398 1.00 43.52  ?  1006 SER   C OG    1 
ATOM   6285 N N     . GLU   A 1 1007 ? 156.700 135.302 149.526 1.00 38.29  ?  1007 GLU   C N     1 
ATOM   6286 C CA    . GLU   A 1 1007 ? 156.136 134.184 148.784 1.00 34.53  ?  1007 GLU   C CA    1 
ATOM   6287 C C     . GLU   A 1 1007 ? 157.223 133.185 148.393 1.00 33.62  ?  1007 GLU   C C     1 
ATOM   6288 O O     . GLU   A 1 1007 ? 157.199 132.613 147.305 1.00 34.43  ?  1007 GLU   C O     1 
ATOM   6289 C CB    . GLU   A 1 1007 ? 155.377 134.690 147.554 1.00 34.16  ?  1007 GLU   C CB    1 
ATOM   6290 C CG    . GLU   A 1 1007 ? 154.194 135.606 147.906 1.00 42.97  ?  1007 GLU   C CG    1 
ATOM   6291 C CD    . GLU   A 1 1007 ? 153.351 136.014 146.718 1.00 54.89  ?  1007 GLU   C CD    1 
ATOM   6292 O OE1   . GLU   A 1 1007 ? 153.812 135.894 145.610 1.00 48.01  ?  1007 GLU   C OE1   1 
ATOM   6293 O OE2   . GLU   A 1 1007 ? 152.244 136.453 146.929 1.00 40.41  -1 1007 GLU   C OE2   1 
ATOM   6294 N N     . MET   A 1 1008 ? 158.151 132.951 149.315 1.00 33.19  ?  1008 MET   C N     1 
ATOM   6295 C CA    . MET   A 1 1008 ? 159.206 131.965 149.156 1.00 33.48  ?  1008 MET   C CA    1 
ATOM   6296 C C     . MET   A 1 1008 ? 159.219 131.081 150.383 1.00 33.69  ?  1008 MET   C C     1 
ATOM   6297 O O     . MET   A 1 1008 ? 158.916 131.536 151.485 1.00 30.72  ?  1008 MET   C O     1 
ATOM   6298 C CB    . MET   A 1 1008 ? 160.578 132.608 148.987 1.00 37.65  ?  1008 MET   C CB    1 
ATOM   6299 C CG    . MET   A 1 1008 ? 160.817 133.382 147.705 1.00 37.14  ?  1008 MET   C CG    1 
ATOM   6300 S SD    . MET   A 1 1008 ? 162.574 133.807 147.520 1.00 43.90  ?  1008 MET   C SD    1 
ATOM   6301 C CE    . MET   A 1 1008 ? 162.616 134.839 146.073 1.00 38.42  ?  1008 MET   C CE    1 
ATOM   6302 N N     . TYR   A 1 1009 ? 159.556 129.816 150.200 1.00 35.21  ?  1009 TYR   C N     1 
ATOM   6303 C CA    . TYR   A 1 1009 ? 159.546 128.891 151.316 1.00 31.79  ?  1009 TYR   C CA    1 
ATOM   6304 C C     . TYR   A 1 1009 ? 160.882 128.202 151.438 1.00 36.25  ?  1009 TYR   C C     1 
ATOM   6305 O O     . TYR   A 1 1009 ? 161.524 127.898 150.432 1.00 39.24  ?  1009 TYR   C O     1 
ATOM   6306 C CB    . TYR   A 1 1009 ? 158.395 127.912 151.137 1.00 22.73  ?  1009 TYR   C CB    1 
ATOM   6307 C CG    . TYR   A 1 1009 ? 157.097 128.658 151.025 1.00 19.69  ?  1009 TYR   C CG    1 
ATOM   6308 C CD1   . TYR   A 1 1009 ? 156.635 129.050 149.786 1.00 16.12  ?  1009 TYR   C CD1   1 
ATOM   6309 C CD2   . TYR   A 1 1009 ? 156.395 128.992 152.157 1.00 22.94  ?  1009 TYR   C CD2   1 
ATOM   6310 C CE1   . TYR   A 1 1009 ? 155.476 129.774 149.685 1.00 18.60  ?  1009 TYR   C CE1   1 
ATOM   6311 C CE2   . TYR   A 1 1009 ? 155.235 129.716 152.054 1.00 19.37  ?  1009 TYR   C CE2   1 
ATOM   6312 C CZ    . TYR   A 1 1009 ? 154.776 130.108 150.826 1.00 16.25  ?  1009 TYR   C CZ    1 
ATOM   6313 O OH    . TYR   A 1 1009 ? 153.612 130.840 150.727 1.00 29.21  ?  1009 TYR   C OH    1 
ATOM   6314 N N     . PHE   A 1 1010 ? 161.313 127.992 152.673 1.00 44.70  ?  1010 PHE   C N     1 
ATOM   6315 C CA    . PHE   A 1 1010 ? 162.645 127.475 152.924 1.00 52.97  ?  1010 PHE   C CA    1 
ATOM   6316 C C     . PHE   A 1 1010 ? 162.661 126.494 154.078 1.00 59.50  ?  1010 PHE   C C     1 
ATOM   6317 O O     . PHE   A 1 1010 ? 161.645 126.275 154.740 1.00 52.06  ?  1010 PHE   C O     1 
ATOM   6318 C CB    . PHE   A 1 1010 ? 163.588 128.628 153.255 1.00 54.79  ?  1010 PHE   C CB    1 
ATOM   6319 C CG    . PHE   A 1 1010 ? 163.590 129.712 152.244 1.00 50.45  ?  1010 PHE   C CG    1 
ATOM   6320 C CD1   . PHE   A 1 1010 ? 162.839 130.854 152.449 1.00 48.24  ?  1010 PHE   C CD1   1 
ATOM   6321 C CD2   . PHE   A 1 1010 ? 164.333 129.601 151.089 1.00 54.89  ?  1010 PHE   C CD2   1 
ATOM   6322 C CE1   . PHE   A 1 1010 ? 162.834 131.862 151.523 1.00 45.52  ?  1010 PHE   C CE1   1 
ATOM   6323 C CE2   . PHE   A 1 1010 ? 164.327 130.606 150.160 1.00 53.47  ?  1010 PHE   C CE2   1 
ATOM   6324 C CZ    . PHE   A 1 1010 ? 163.578 131.736 150.380 1.00 47.46  ?  1010 PHE   C CZ    1 
ATOM   6325 N N     . ASN   A 1 1011 ? 163.835 125.939 154.341 1.00 57.34  ?  1011 ASN   C N     1 
ATOM   6326 C CA    . ASN   A 1 1011 ? 164.015 125.036 155.465 1.00 54.55  ?  1011 ASN   C CA    1 
ATOM   6327 C C     . ASN   A 1 1011 ? 164.176 125.809 156.774 1.00 63.11  ?  1011 ASN   C C     1 
ATOM   6328 O O     . ASN   A 1 1011 ? 164.150 127.044 156.790 1.00 59.70  ?  1011 ASN   C O     1 
ATOM   6329 C CB    . ASN   A 1 1011 ? 165.194 124.116 155.207 1.00 63.17  ?  1011 ASN   C CB    1 
ATOM   6330 C CG    . ASN   A 1 1011 ? 166.513 124.845 155.093 1.00 60.15  ?  1011 ASN   C CG    1 
ATOM   6331 O OD1   . ASN   A 1 1011 ? 166.665 125.985 155.547 1.00 58.36  ?  1011 ASN   C OD1   1 
ATOM   6332 N ND2   . ASN   A 1 1011 ? 167.476 124.196 154.485 1.00 64.70  ?  1011 ASN   C ND2   1 
ATOM   6333 N N     . TYR   A 1 1012 ? 164.326 125.076 157.875 1.00 62.42  ?  1012 TYR   C N     1 
ATOM   6334 C CA    . TYR   A 1 1012 ? 164.394 125.703 159.189 1.00 61.95  ?  1012 TYR   C CA    1 
ATOM   6335 C C     . TYR   A 1 1012 ? 165.665 126.520 159.366 1.00 62.42  ?  1012 TYR   C C     1 
ATOM   6336 O O     . TYR   A 1 1012 ? 165.646 127.588 159.982 1.00 64.00  ?  1012 TYR   C O     1 
ATOM   6337 C CB    . TYR   A 1 1012 ? 164.322 124.643 160.293 1.00 54.44  ?  1012 TYR   C CB    1 
ATOM   6338 C CG    . TYR   A 1 1012 ? 162.994 123.898 160.401 1.00 63.91  ?  1012 TYR   C CG    1 
ATOM   6339 C CD1   . TYR   A 1 1012 ? 162.990 122.496 160.533 1.00 74.63  ?  1012 TYR   C CD1   1 
ATOM   6340 C CD2   . TYR   A 1 1012 ? 161.787 124.589 160.375 1.00 85.48  ?  1012 TYR   C CD2   1 
ATOM   6341 C CE1   . TYR   A 1 1012 ? 161.791 121.807 160.638 1.00 28.14  ?  1012 TYR   C CE1   1 
ATOM   6342 C CE2   . TYR   A 1 1012 ? 160.589 123.890 160.483 1.00 75.22  ?  1012 TYR   C CE2   1 
ATOM   6343 C CZ    . TYR   A 1 1012 ? 160.590 122.512 160.611 1.00 40.63  ?  1012 TYR   C CZ    1 
ATOM   6344 O OH    . TYR   A 1 1012 ? 159.403 121.842 160.714 1.00 34.03  ?  1012 TYR   C OH    1 
ATOM   6345 N N     . GLU   A 1 1013 ? 166.774 126.017 158.835 1.00 58.79  ?  1013 GLU   C N     1 
ATOM   6346 C CA    . GLU   A 1 1013 ? 168.048 126.704 158.987 1.00 61.49  ?  1013 GLU   C CA    1 
ATOM   6347 C C     . GLU   A 1 1013 ? 168.017 128.073 158.334 1.00 73.91  ?  1013 GLU   C C     1 
ATOM   6348 O O     . GLU   A 1 1013 ? 168.507 129.051 158.899 1.00 61.68  ?  1013 GLU   C O     1 
ATOM   6349 C CB    . GLU   A 1 1013 ? 169.184 125.883 158.385 1.00 61.72  ?  1013 GLU   C CB    1 
ATOM   6350 C CG    . GLU   A 1 1013 ? 170.554 126.521 158.557 1.00 67.30  ?  1013 GLU   C CG    1 
ATOM   6351 C CD    . GLU   A 1 1013 ? 171.668 125.676 158.029 1.00 68.61  ?  1013 GLU   C CD    1 
ATOM   6352 O OE1   . GLU   A 1 1013 ? 171.395 124.613 157.527 1.00 74.08  ?  1013 GLU   C OE1   1 
ATOM   6353 O OE2   . GLU   A 1 1013 ? 172.799 126.087 158.133 1.00 74.09  -1 1013 GLU   C OE2   1 
ATOM   6354 N N     . THR   A 1 1014 ? 167.434 128.139 157.144 1.00 60.48  ?  1014 THR   C N     1 
ATOM   6355 C CA    . THR   A 1 1014 ? 167.366 129.379 156.394 1.00 61.18  ?  1014 THR   C CA    1 
ATOM   6356 C C     . THR   A 1 1014 ? 166.538 130.413 157.130 1.00 65.51  ?  1014 THR   C C     1 
ATOM   6357 O O     . THR   A 1 1014 ? 166.933 131.576 157.223 1.00 60.28  ?  1014 THR   C O     1 
ATOM   6358 C CB    . THR   A 1 1014 ? 166.773 129.140 155.002 1.00 61.86  ?  1014 THR   C CB    1 
ATOM   6359 O OG1   . THR   A 1 1014 ? 167.589 128.201 154.294 1.00 62.72  ?  1014 THR   C OG1   1 
ATOM   6360 C CG2   . THR   A 1 1014 ? 166.725 130.441 154.218 1.00 63.08  ?  1014 THR   C CG2   1 
ATOM   6361 N N     . LYS   A 1 1015 ? 165.390 129.999 157.656 1.00 59.01  ?  1015 LYS   C N     1 
ATOM   6362 C CA    . LYS   A 1 1015 ? 164.541 130.930 158.379 1.00 63.42  ?  1015 LYS   C CA    1 
ATOM   6363 C C     . LYS   A 1 1015 ? 165.295 131.503 159.572 1.00 72.03  ?  1015 LYS   C C     1 
ATOM   6364 O O     . LYS   A 1 1015 ? 165.261 132.709 159.818 1.00 65.19  ?  1015 LYS   C O     1 
ATOM   6365 C CB    . LYS   A 1 1015 ? 163.250 130.247 158.833 1.00 61.60  ?  1015 LYS   C CB    1 
ATOM   6366 C CG    . LYS   A 1 1015 ? 162.248 131.175 159.526 1.00 66.25  ?  1015 LYS   C CG    1 
ATOM   6367 C CD    . LYS   A 1 1015 ? 160.954 130.431 159.883 1.00 77.63  ?  1015 LYS   C CD    1 
ATOM   6368 C CE    . LYS   A 1 1015 ? 159.861 131.386 160.385 1.00 65.70  ?  1015 LYS   C CE    1 
ATOM   6369 N NZ    . LYS   A 1 1015 ? 160.234 132.055 161.668 1.00 63.68  1  1015 LYS   C NZ    1 
ATOM   6370 N N     . SER   A 1 1016 ? 166.002 130.636 160.294 1.00 64.32  ?  1016 SER   C N     1 
ATOM   6371 C CA    . SER   A 1 1016 ? 166.778 131.067 161.448 1.00 66.00  ?  1016 SER   C CA    1 
ATOM   6372 C C     . SER   A 1 1016 ? 167.877 132.038 161.041 1.00 64.96  ?  1016 SER   C C     1 
ATOM   6373 O O     . SER   A 1 1016 ? 168.099 133.053 161.708 1.00 66.12  ?  1016 SER   C O     1 
ATOM   6374 C CB    . SER   A 1 1016 ? 167.385 129.864 162.140 1.00 69.50  ?  1016 SER   C CB    1 
ATOM   6375 O OG    . SER   A 1 1016 ? 168.132 130.253 163.260 1.00 69.66  ?  1016 SER   C OG    1 
ATOM   6376 N N     . ALA   A 1 1017 ? 168.570 131.731 159.946 1.00 63.00  ?  1017 ALA   C N     1 
ATOM   6377 C CA    . ALA   A 1 1017 ? 169.650 132.578 159.465 1.00 64.98  ?  1017 ALA   C CA    1 
ATOM   6378 C C     . ALA   A 1 1017 ? 169.151 133.978 159.130 1.00 64.46  ?  1017 ALA   C C     1 
ATOM   6379 O O     . ALA   A 1 1017 ? 169.804 134.968 159.454 1.00 65.37  ?  1017 ALA   C O     1 
ATOM   6380 C CB    . ALA   A 1 1017 ? 170.299 131.957 158.242 1.00 62.09  ?  1017 ALA   C CB    1 
ATOM   6381 N N     . LEU   A 1 1018 ? 167.977 134.060 158.503 1.00 64.44  ?  1018 LEU   C N     1 
ATOM   6382 C CA    . LEU   A 1 1018 ? 167.420 135.361 158.155 1.00 63.81  ?  1018 LEU   C CA    1 
ATOM   6383 C C     . LEU   A 1 1018 ? 167.023 136.147 159.396 1.00 62.05  ?  1018 LEU   C C     1 
ATOM   6384 O O     . LEU   A 1 1018 ? 167.291 137.349 159.485 1.00 62.42  ?  1018 LEU   C O     1 
ATOM   6385 C CB    . LEU   A 1 1018 ? 166.201 135.190 157.239 1.00 59.47  ?  1018 LEU   C CB    1 
ATOM   6386 C CG    . LEU   A 1 1018 ? 166.479 134.720 155.797 1.00 55.90  ?  1018 LEU   C CG    1 
ATOM   6387 C CD1   . LEU   A 1 1018 ? 165.160 134.361 155.129 1.00 52.99  ?  1018 LEU   C CD1   1 
ATOM   6388 C CD2   . LEU   A 1 1018 ? 167.173 135.836 155.023 1.00 54.30  ?  1018 LEU   C CD2   1 
ATOM   6389 N N     . GLU   A 1 1019 ? 166.419 135.474 160.371 1.00 65.08  ?  1019 GLU   C N     1 
ATOM   6390 C CA    . GLU   A 1 1019 ? 166.046 136.148 161.607 1.00 65.51  ?  1019 GLU   C CA    1 
ATOM   6391 C C     . GLU   A 1 1019 ? 167.294 136.625 162.333 1.00 64.02  ?  1019 GLU   C C     1 
ATOM   6392 O O     . GLU   A 1 1019 ? 167.328 137.728 162.882 1.00 66.77  ?  1019 GLU   C O     1 
ATOM   6393 C CB    . GLU   A 1 1019 ? 165.235 135.220 162.511 1.00 68.23  ?  1019 GLU   C CB    1 
ATOM   6394 C CG    . GLU   A 1 1019 ? 163.839 134.908 161.998 1.00 72.57  ?  1019 GLU   C CG    1 
ATOM   6395 C CD    . GLU   A 1 1019 ? 163.104 133.918 162.858 1.00 81.48  ?  1019 GLU   C CD    1 
ATOM   6396 O OE1   . GLU   A 1 1019 ? 163.695 133.404 163.777 1.00 80.58  ?  1019 GLU   C OE1   1 
ATOM   6397 O OE2   . GLU   A 1 1019 ? 161.946 133.677 162.596 1.00 77.30  -1 1019 GLU   C OE2   1 
ATOM   6398 N N     . THR   A 1 1020 ? 168.333 135.797 162.300 1.00 64.09  ?  1020 THR   C N     1 
ATOM   6399 C CA    . THR   A 1 1020 ? 169.595 136.134 162.932 1.00 64.88  ?  1020 THR   C CA    1 
ATOM   6400 C C     . THR   A 1 1020 ? 170.185 137.376 162.290 1.00 80.45  ?  1020 THR   C C     1 
ATOM   6401 O O     . THR   A 1 1020 ? 170.611 138.298 162.987 1.00 64.54  ?  1020 THR   C O     1 
ATOM   6402 C CB    . THR   A 1 1020 ? 170.591 134.965 162.825 1.00 67.26  ?  1020 THR   C CB    1 
ATOM   6403 O OG1   . THR   A 1 1020 ? 170.059 133.816 163.500 1.00 67.62  ?  1020 THR   C OG1   1 
ATOM   6404 C CG2   . THR   A 1 1020 ? 171.914 135.350 163.453 1.00 71.90  ?  1020 THR   C CG2   1 
ATOM   6405 N N     . LEU   A 1 1021 ? 170.172 137.419 160.960 1.00 64.33  ?  1021 LEU   C N     1 
ATOM   6406 C CA    . LEU   A 1 1021 ? 170.709 138.555 160.223 1.00 65.90  ?  1021 LEU   C CA    1 
ATOM   6407 C C     . LEU   A 1 1021 ? 170.034 139.851 160.640 1.00 64.02  ?  1021 LEU   C C     1 
ATOM   6408 O O     . LEU   A 1 1021 ? 170.698 140.870 160.829 1.00 65.49  ?  1021 LEU   C O     1 
ATOM   6409 C CB    . LEU   A 1 1021 ? 170.514 138.343 158.713 1.00 64.39  ?  1021 LEU   C CB    1 
ATOM   6410 C CG    . LEU   A 1 1021 ? 171.015 139.472 157.776 1.00 63.79  ?  1021 LEU   C CG    1 
ATOM   6411 C CD1   . LEU   A 1 1021 ? 172.533 139.632 157.905 1.00 67.28  ?  1021 LEU   C CD1   1 
ATOM   6412 C CD2   . LEU   A 1 1021 ? 170.630 139.130 156.342 1.00 65.12  ?  1021 LEU   C CD2   1 
ATOM   6413 N N     . GLN   A 1 1022 ? 168.714 139.817 160.801 1.00 64.50  ?  1022 GLN   C N     1 
ATOM   6414 C CA    . GLN   A 1 1022 ? 167.988 141.021 161.184 1.00 64.68  ?  1022 GLN   C CA    1 
ATOM   6415 C C     . GLN   A 1 1022 ? 168.447 141.554 162.536 1.00 67.30  ?  1022 GLN   C C     1 
ATOM   6416 O O     . GLN   A 1 1022 ? 168.526 142.767 162.735 1.00 68.20  ?  1022 GLN   C O     1 
ATOM   6417 C CB    . GLN   A 1 1022 ? 166.483 140.760 161.237 1.00 61.82  ?  1022 GLN   C CB    1 
ATOM   6418 C CG    . GLN   A 1 1022 ? 165.843 140.539 159.891 1.00 59.26  ?  1022 GLN   C CG    1 
ATOM   6419 C CD    . GLN   A 1 1022 ? 164.339 140.389 159.993 1.00 61.80  ?  1022 GLN   C CD    1 
ATOM   6420 O OE1   . GLN   A 1 1022 ? 163.679 141.179 160.672 1.00 62.11  ?  1022 GLN   C OE1   1 
ATOM   6421 N NE2   . GLN   A 1 1022 ? 163.788 139.387 159.323 1.00 59.68  ?  1022 GLN   C NE2   1 
ATOM   6422 N N     . GLU   A 1 1023 ? 168.752 140.652 163.463 1.00 67.44  ?  1023 GLU   C N     1 
ATOM   6423 C CA    . GLU   A 1 1023 ? 169.206 141.070 164.783 1.00 69.39  ?  1023 GLU   C CA    1 
ATOM   6424 C C     . GLU   A 1 1023 ? 170.670 141.504 164.786 1.00 70.06  ?  1023 GLU   C C     1 
ATOM   6425 O O     . GLU   A 1 1023 ? 171.029 142.488 165.433 1.00 71.49  ?  1023 GLU   C O     1 
ATOM   6426 C CB    . GLU   A 1 1023 ? 169.017 139.942 165.799 1.00 70.96  ?  1023 GLU   C CB    1 
ATOM   6427 C CG    . GLU   A 1 1023 ? 167.570 139.624 166.133 1.00 77.85  ?  1023 GLU   C CG    1 
ATOM   6428 C CD    . GLU   A 1 1023 ? 167.440 138.553 167.185 1.00 83.86  ?  1023 GLU   C CD    1 
ATOM   6429 O OE1   . GLU   A 1 1023 ? 168.434 137.949 167.511 1.00 79.66  ?  1023 GLU   C OE1   1 
ATOM   6430 O OE2   . GLU   A 1 1023 ? 166.350 138.343 167.664 1.00 80.14  -1 1023 GLU   C OE2   1 
ATOM   6431 N N     . GLU   A 1 1024 ? 171.515 140.762 164.074 1.00 69.58  ?  1024 GLU   C N     1 
ATOM   6432 C CA    . GLU   A 1 1024 ? 172.945 141.046 164.062 1.00 73.00  ?  1024 GLU   C CA    1 
ATOM   6433 C C     . GLU   A 1 1024 ? 173.290 142.309 163.288 1.00 72.68  ?  1024 GLU   C C     1 
ATOM   6434 O O     . GLU   A 1 1024 ? 174.193 143.051 163.680 1.00 75.58  ?  1024 GLU   C O     1 
ATOM   6435 C CB    . GLU   A 1 1024 ? 173.729 139.865 163.482 1.00 75.20  ?  1024 GLU   C CB    1 
ATOM   6436 C CG    . GLU   A 1 1024 ? 173.793 138.640 164.390 1.00 84.22  ?  1024 GLU   C CG    1 
ATOM   6437 C CD    . GLU   A 1 1024 ? 174.591 137.510 163.795 1.00 84.90  ?  1024 GLU   C CD    1 
ATOM   6438 O OE1   . GLU   A 1 1024 ? 174.797 137.515 162.605 1.00 86.04  ?  1024 GLU   C OE1   1 
ATOM   6439 O OE2   . GLU   A 1 1024 ? 174.997 136.641 164.531 1.00 88.53  -1 1024 GLU   C OE2   1 
ATOM   6440 N N     . LYS   A 1 1025 ? 172.581 142.549 162.188 1.00 72.76  ?  1025 LYS   C N     1 
ATOM   6441 C CA    . LYS   A 1 1025 ? 172.859 143.686 161.325 1.00 71.55  ?  1025 LYS   C CA    1 
ATOM   6442 C C     . LYS   A 1 1025 ? 171.604 144.525 161.085 1.00 66.21  ?  1025 LYS   C C     1 
ATOM   6443 O O     . LYS   A 1 1025 ? 171.052 144.491 159.983 1.00 63.19  ?  1025 LYS   C O     1 
ATOM   6444 C CB    . LYS   A 1 1025 ? 173.409 143.195 159.983 1.00 75.85  ?  1025 LYS   C CB    1 
ATOM   6445 C CG    . LYS   A 1 1025 ? 174.656 142.323 160.087 1.00 79.61  ?  1025 LYS   C CG    1 
ATOM   6446 C CD    . LYS   A 1 1025 ? 175.866 143.112 160.570 1.00 82.63  ?  1025 LYS   C CD    1 
ATOM   6447 C CE    . LYS   A 1 1025 ? 177.098 142.233 160.653 1.00 84.34  ?  1025 LYS   C CE    1 
ATOM   6448 N NZ    . LYS   A 1 1025 ? 178.275 142.976 161.168 1.00 83.06  1  1025 LYS   C NZ    1 
ATOM   6449 N N     . PRO   A 1 1026 ? 171.176 145.319 162.082 1.00 67.13  ?  1026 PRO   C N     1 
ATOM   6450 C CA    . PRO   A 1 1026 ? 169.906 146.020 162.170 1.00 62.64  ?  1026 PRO   C CA    1 
ATOM   6451 C C     . PRO   A 1 1026 ? 169.748 147.095 161.106 1.00 60.52  ?  1026 PRO   C C     1 
ATOM   6452 O O     . PRO   A 1 1026 ? 168.646 147.595 160.888 1.00 59.16  ?  1026 PRO   C O     1 
ATOM   6453 C CB    . PRO   A 1 1026 ? 169.953 146.627 163.577 1.00 65.17  ?  1026 PRO   C CB    1 
ATOM   6454 C CG    . PRO   A 1 1026 ? 171.417 146.752 163.893 1.00 68.73  ?  1026 PRO   C CG    1 
ATOM   6455 C CD    . PRO   A 1 1026 ? 172.066 145.568 163.225 1.00 67.17  ?  1026 PRO   C CD    1 
ATOM   6456 N N     . GLU   A 1 1027 ? 170.844 147.457 160.444 1.00 61.35  ?  1027 GLU   C N     1 
ATOM   6457 C CA    . GLU   A 1 1027 ? 170.769 148.435 159.372 1.00 62.39  ?  1027 GLU   C CA    1 
ATOM   6458 C C     . GLU   A 1 1027 ? 169.860 147.921 158.265 1.00 56.38  ?  1027 GLU   C C     1 
ATOM   6459 O O     . GLU   A 1 1027 ? 169.111 148.688 157.658 1.00 51.07  ?  1027 GLU   C O     1 
ATOM   6460 C CB    . GLU   A 1 1027 ? 172.164 148.746 158.832 1.00 63.61  ?  1027 GLU   C CB    1 
ATOM   6461 C CG    . GLU   A 1 1027 ? 173.052 149.505 159.814 1.00 64.00  ?  1027 GLU   C CG    1 
ATOM   6462 C CD    . GLU   A 1 1027 ? 173.668 148.616 160.861 1.00 69.29  ?  1027 GLU   C CD    1 
ATOM   6463 O OE1   . GLU   A 1 1027 ? 173.445 147.430 160.812 1.00 67.99  ?  1027 GLU   C OE1   1 
ATOM   6464 O OE2   . GLU   A 1 1027 ? 174.354 149.123 161.715 1.00 66.27  -1 1027 GLU   C OE2   1 
ATOM   6465 N N     . LEU   A 1 1028 ? 169.889 146.609 158.031 1.00 54.70  ?  1028 LEU   C N     1 
ATOM   6466 C CA    . LEU   A 1 1028 ? 169.002 146.007 157.048 1.00 49.63  ?  1028 LEU   C CA    1 
ATOM   6467 C C     . LEU   A 1 1028 ? 167.696 145.708 157.745 1.00 51.10  ?  1028 LEU   C C     1 
ATOM   6468 O O     . LEU   A 1 1028 ? 167.371 144.557 158.036 1.00 53.02  ?  1028 LEU   C O     1 
ATOM   6469 C CB    . LEU   A 1 1028 ? 169.605 144.720 156.465 1.00 46.26  ?  1028 LEU   C CB    1 
ATOM   6470 C CG    . LEU   A 1 1028 ? 168.809 144.042 155.301 1.00 49.40  ?  1028 LEU   C CG    1 
ATOM   6471 C CD1   . LEU   A 1 1028 ? 168.723 144.988 154.100 1.00 46.98  ?  1028 LEU   C CD1   1 
ATOM   6472 C CD2   . LEU   A 1 1028 ? 169.507 142.739 154.908 1.00 57.31  ?  1028 LEU   C CD2   1 
ATOM   6473 N N     . THR   A 1 1029 ? 166.973 146.773 158.046 1.00 51.90  ?  1029 THR   C N     1 
ATOM   6474 C CA    . THR   A 1 1029 ? 165.797 146.707 158.893 1.00 59.37  ?  1029 THR   C CA    1 
ATOM   6475 C C     . THR   A 1 1029 ? 164.780 145.706 158.388 1.00 58.40  ?  1029 THR   C C     1 
ATOM   6476 O O     . THR   A 1 1029 ? 164.171 144.980 159.173 1.00 60.09  ?  1029 THR   C O     1 
ATOM   6477 C CB    . THR   A 1 1029 ? 165.125 148.092 159.009 1.00 63.15  ?  1029 THR   C CB    1 
ATOM   6478 O OG1   . THR   A 1 1029 ? 166.033 149.018 159.619 1.00 62.44  ?  1029 THR   C OG1   1 
ATOM   6479 C CG2   . THR   A 1 1029 ? 163.859 148.006 159.855 1.00 61.60  ?  1029 THR   C CG2   1 
ATOM   6480 N N     . VAL   A 1 1030 ? 164.556 145.689 157.085 1.00 48.60  ?  1030 VAL   C N     1 
ATOM   6481 C CA    . VAL   A 1 1030 ? 163.500 144.849 156.556 1.00 46.52  ?  1030 VAL   C CA    1 
ATOM   6482 C C     . VAL   A 1 1030 ? 163.991 143.731 155.658 1.00 43.88  ?  1030 VAL   C C     1 
ATOM   6483 O O     . VAL   A 1 1030 ? 164.651 143.960 154.646 1.00 45.73  ?  1030 VAL   C O     1 
ATOM   6484 C CB    . VAL   A 1 1030 ? 162.491 145.703 155.767 1.00 50.92  ?  1030 VAL   C CB    1 
ATOM   6485 C CG1   . VAL   A 1 1030 ? 161.387 144.815 155.187 1.00 49.14  ?  1030 VAL   C CG1   1 
ATOM   6486 C CG2   . VAL   A 1 1030 ? 161.898 146.760 156.678 1.00 57.00  ?  1030 VAL   C CG2   1 
ATOM   6487 N N     . VAL   A 1 1031 ? 163.595 142.521 156.003 1.00 42.51  ?  1031 VAL   C N     1 
ATOM   6488 C CA    . VAL   A 1 1031 ? 163.796 141.374 155.141 1.00 40.92  ?  1031 VAL   C CA    1 
ATOM   6489 C C     . VAL   A 1 1031 ? 162.443 140.944 154.610 1.00 41.79  ?  1031 VAL   C C     1 
ATOM   6490 O O     . VAL   A 1 1031 ? 162.311 140.590 153.447 1.00 42.66  ?  1031 VAL   C O     1 
ATOM   6491 C CB    . VAL   A 1 1031 ? 164.497 140.229 155.868 1.00 49.07  ?  1031 VAL   C CB    1 
ATOM   6492 C CG1   . VAL   A 1 1031 ? 164.551 139.011 154.969 1.00 48.71  ?  1031 VAL   C CG1   1 
ATOM   6493 C CG2   . VAL   A 1 1031 ? 165.911 140.665 156.247 1.00 50.78  ?  1031 VAL   C CG2   1 
ATOM   6494 N N     . PHE   A 1 1032 ? 161.437 141.006 155.477 1.00 43.92  ?  1032 PHE   C N     1 
ATOM   6495 C CA    . PHE   A 1 1032 ? 160.055 140.692 155.131 1.00 45.76  ?  1032 PHE   C CA    1 
ATOM   6496 C C     . PHE   A 1 1032 ? 159.822 139.238 154.731 1.00 50.25  ?  1032 PHE   C C     1 
ATOM   6497 O O     . PHE   A 1 1032 ? 159.251 138.956 153.678 1.00 47.28  ?  1032 PHE   C O     1 
ATOM   6498 C CB    . PHE   A 1 1032 ? 159.580 141.620 154.012 1.00 46.02  ?  1032 PHE   C CB    1 
ATOM   6499 C CG    . PHE   A 1 1032 ? 158.101 141.595 153.774 1.00 55.20  ?  1032 PHE   C CG    1 
ATOM   6500 C CD1   . PHE   A 1 1032 ? 157.223 142.151 154.697 1.00 56.29  ?  1032 PHE   C CD1   1 
ATOM   6501 C CD2   . PHE   A 1 1032 ? 157.583 141.031 152.626 1.00 55.02  ?  1032 PHE   C CD2   1 
ATOM   6502 C CE1   . PHE   A 1 1032 ? 155.863 142.132 154.472 1.00 54.92  ?  1032 PHE   C CE1   1 
ATOM   6503 C CE2   . PHE   A 1 1032 ? 156.225 141.011 152.397 1.00 62.11  ?  1032 PHE   C CE2   1 
ATOM   6504 C CZ    . PHE   A 1 1032 ? 155.364 141.563 153.322 1.00 68.98  ?  1032 PHE   C CZ    1 
ATOM   6505 N N     . GLU   A 1 1033 ? 160.229 138.312 155.593 1.00 51.68  ?  1033 GLU   C N     1 
ATOM   6506 C CA    . GLU   A 1 1033 ? 159.937 136.902 155.373 1.00 49.62  ?  1033 GLU   C CA    1 
ATOM   6507 C C     . GLU   A 1 1033 ? 158.422 136.694 155.447 1.00 50.10  ?  1033 GLU   C C     1 
ATOM   6508 O O     . GLU   A 1 1033 ? 157.753 137.366 156.231 1.00 50.95  ?  1033 GLU   C O     1 
ATOM   6509 C CB    . GLU   A 1 1033 ? 160.632 136.038 156.427 1.00 52.75  ?  1033 GLU   C CB    1 
ATOM   6510 C CG    . GLU   A 1 1033 ? 162.134 136.186 156.466 1.00 53.78  ?  1033 GLU   C CG    1 
ATOM   6511 C CD    . GLU   A 1 1033 ? 162.585 137.295 157.365 1.00 57.00  ?  1033 GLU   C CD    1 
ATOM   6512 O OE1   . GLU   A 1 1033 ? 161.766 138.073 157.799 1.00 57.75  ?  1033 GLU   C OE1   1 
ATOM   6513 O OE2   . GLU   A 1 1033 ? 163.755 137.375 157.628 1.00 57.46  -1 1033 GLU   C OE2   1 
ATOM   6514 N N     . PRO   A 1 1034 ? 157.862 135.775 154.652 1.00 47.98  ?  1034 PRO   C N     1 
ATOM   6515 C CA    . PRO   A 1 1034 ? 156.444 135.429 154.595 1.00 52.38  ?  1034 PRO   C CA    1 
ATOM   6516 C C     . PRO   A 1 1034 ? 155.879 134.743 155.856 1.00 52.12  ?  1034 PRO   C C     1 
ATOM   6517 O O     . PRO   A 1 1034 ? 154.660 134.732 156.047 1.00 39.18  ?  1034 PRO   C O     1 
ATOM   6518 C CB    . PRO   A 1 1034 ? 156.394 134.489 153.379 1.00 46.87  ?  1034 PRO   C CB    1 
ATOM   6519 C CG    . PRO   A 1 1034 ? 157.794 133.917 153.264 1.00 44.52  ?  1034 PRO   C CG    1 
ATOM   6520 C CD    . PRO   A 1 1034 ? 158.714 135.015 153.731 1.00 43.35  ?  1034 PRO   C CD    1 
ATOM   6521 N N     . SER   A 1 1035 ? 156.755 134.168 156.695 1.00 51.90  ?  1035 SER   C N     1 
ATOM   6522 C CA    . SER   A 1 1035 ? 156.366 133.458 157.917 1.00 54.05  ?  1035 SER   C CA    1 
ATOM   6523 C C     . SER   A 1 1035 ? 157.162 133.969 159.118 1.00 58.49  ?  1035 SER   C C     1 
ATOM   6524 O O     . SER   A 1 1035 ? 158.371 134.180 159.012 1.00 59.76  ?  1035 SER   C O     1 
ATOM   6525 C CB    . SER   A 1 1035 ? 156.576 131.954 157.748 1.00 63.56  ?  1035 SER   C CB    1 
ATOM   6526 O OG    . SER   A 1 1035 ? 155.755 131.435 156.738 1.00 62.77  ?  1035 SER   C OG    1 
HETATM 6527 P PG    . ATP   B 2 .    ? 106.328 154.161 152.718 1.00 31.75  ?  1101 ATP   C PG    1 
HETATM 6528 O O1G   . ATP   B 2 .    ? 107.086 155.014 153.701 1.00 31.75  ?  1101 ATP   C O1G   1 
HETATM 6529 O O2G   . ATP   B 2 .    ? 107.065 152.936 152.247 1.00 31.75  -1 1101 ATP   C O2G   1 
HETATM 6530 O O3G   . ATP   B 2 .    ? 104.908 153.910 153.142 1.00 31.75  ?  1101 ATP   C O3G   1 
HETATM 6531 P PB    . ATP   B 2 .    ? 107.369 155.765 150.592 1.00 31.75  ?  1101 ATP   C PB    1 
HETATM 6532 O O1B   . ATP   B 2 .    ? 108.313 156.416 151.558 1.00 31.75  -1 1101 ATP   C O1B   1 
HETATM 6533 O O2B   . ATP   B 2 .    ? 107.913 154.821 149.566 1.00 31.75  ?  1101 ATP   C O2B   1 
HETATM 6534 O O3B   . ATP   B 2 .    ? 106.162 155.078 151.403 1.00 31.75  ?  1101 ATP   C O3B   1 
HETATM 6535 P PA    . ATP   B 2 .    ? 105.103 156.784 149.274 1.00 31.75  ?  1101 ATP   C PA    1 
HETATM 6536 O O1A   . ATP   B 2 .    ? 104.188 156.779 150.463 1.00 31.75  -1 1101 ATP   C O1A   1 
HETATM 6537 O O2A   . ATP   B 2 .    ? 105.009 155.671 148.278 1.00 31.75  ?  1101 ATP   C O2A   1 
HETATM 6538 O O3A   . ATP   B 2 .    ? 106.617 156.930 149.789 1.00 31.75  ?  1101 ATP   C O3A   1 
HETATM 6539 O "O5'" . ATP   B 2 .    ? 104.832 158.176 148.534 1.00 31.75  ?  1101 ATP   C "O5'" 1 
HETATM 6540 C "C5'" . ATP   B 2 .    ? 103.860 159.039 149.104 1.00 31.75  ?  1101 ATP   C "C5'" 1 
HETATM 6541 C "C4'" . ATP   B 2 .    ? 103.343 160.024 148.074 1.00 31.75  ?  1101 ATP   C "C4'" 1 
HETATM 6542 O "O4'" . ATP   B 2 .    ? 104.047 159.849 146.853 1.00 31.75  ?  1101 ATP   C "O4'" 1 
HETATM 6543 C "C3'" . ATP   B 2 .    ? 101.876 159.786 147.780 1.00 31.75  ?  1101 ATP   C "C3'" 1 
HETATM 6544 O "O3'" . ATP   B 2 .    ? 101.097 160.869 148.293 1.00 31.75  ?  1101 ATP   C "O3'" 1 
HETATM 6545 C "C2'" . ATP   B 2 .    ? 101.762 159.744 146.274 1.00 31.75  ?  1101 ATP   C "C2'" 1 
HETATM 6546 O "O2'" . ATP   B 2 .    ? 100.923 160.809 145.825 1.00 31.75  ?  1101 ATP   C "O2'" 1 
HETATM 6547 C "C1'" . ATP   B 2 .    ? 103.161 159.961 145.746 1.00 31.75  ?  1101 ATP   C "C1'" 1 
HETATM 6548 N N9    . ATP   B 2 .    ? 103.507 158.913 144.768 1.00 31.75  ?  1101 ATP   C N9    1 
HETATM 6549 C C8    . ATP   B 2 .    ? 104.368 157.911 144.985 1.00 31.75  ?  1101 ATP   C C8    1 
HETATM 6550 N N7    . ATP   B 2 .    ? 104.484 157.120 143.895 1.00 31.75  ?  1101 ATP   C N7    1 
HETATM 6551 C C5    . ATP   B 2 .    ? 103.682 157.631 142.950 1.00 31.75  ?  1101 ATP   C C5    1 
HETATM 6552 C C6    . ATP   B 2 .    ? 103.331 157.286 141.562 1.00 31.75  ?  1101 ATP   C C6    1 
HETATM 6553 N N6    . ATP   B 2 .    ? 103.880 156.211 140.955 1.00 31.75  ?  1101 ATP   C N6    1 
HETATM 6554 N N1    . ATP   B 2 .    ? 102.451 158.080 140.929 1.00 31.75  ?  1101 ATP   C N1    1 
HETATM 6555 C C2    . ATP   B 2 .    ? 101.904 159.149 141.522 1.00 31.75  ?  1101 ATP   C C2    1 
HETATM 6556 N N3    . ATP   B 2 .    ? 102.175 159.523 142.779 1.00 31.75  ?  1101 ATP   C N3    1 
HETATM 6557 C C4    . ATP   B 2 .    ? 103.044 158.816 143.530 1.00 31.75  ?  1101 ATP   C C4    1 
HETATM 6558 N N1    . A1BLR C 3 .    ? 121.139 160.244 152.740 1.00 19.50  ?  1102 A1BLR C N1    1 
HETATM 6559 N N3    . A1BLR C 3 .    ? 117.103 162.855 150.459 1.00 19.50  ?  1102 A1BLR C N3    1 
HETATM 6560 C C4    . A1BLR C 3 .    ? 122.080 160.524 150.008 1.00 19.50  ?  1102 A1BLR C C4    1 
HETATM 6561 C C5    . A1BLR C 3 .    ? 120.681 160.952 150.426 1.00 19.50  ?  1102 A1BLR C C5    1 
HETATM 6562 C C6    . A1BLR C 3 .    ? 120.213 160.110 151.620 1.00 19.50  ?  1102 A1BLR C C6    1 
HETATM 6563 C C7    . A1BLR C 3 .    ? 118.508 161.365 149.383 1.00 19.50  ?  1102 A1BLR C C7    1 
HETATM 6564 C C8    . A1BLR C 3 .    ? 117.522 161.030 148.471 1.00 19.50  ?  1102 A1BLR C C8    1 
HETATM 6565 C C10   . A1BLR C 3 .    ? 116.121 162.570 149.604 1.00 19.50  ?  1102 A1BLR C C10   1 
HETATM 6566 C C13   . A1BLR C 3 .    ? 113.617 165.294 150.321 1.00 19.50  ?  1102 A1BLR C C13   1 
HETATM 6567 C C15   . A1BLR C 3 .    ? 112.439 163.219 150.194 1.00 19.50  ?  1102 A1BLR C C15   1 
HETATM 6568 C C17   . A1BLR C 3 .    ? 111.140 165.290 150.658 1.00 19.50  ?  1102 A1BLR C C17   1 
HETATM 6569 C C1    . A1BLR C 3 .    ? 120.646 159.498 153.896 1.00 19.50  ?  1102 A1BLR C C1    1 
HETATM 6570 O O1    . A1BLR C 3 .    ? 113.586 161.207 149.752 1.00 19.50  ?  1102 A1BLR C O1    1 
HETATM 6571 C C2    . A1BLR C 3 .    ? 122.453 159.743 152.331 1.00 19.50  ?  1102 A1BLR C C2    1 
HETATM 6572 N N2    . A1BLR C 3 .    ? 119.740 160.818 149.327 1.00 19.50  ?  1102 A1BLR C N2    1 
HETATM 6573 C C3    . A1BLR C 3 .    ? 123.022 160.571 151.204 1.00 19.50  ?  1102 A1BLR C C3    1 
HETATM 6574 N N4    . A1BLR C 3 .    ? 118.300 162.256 150.345 1.00 19.50  ?  1102 A1BLR C N4    1 
HETATM 6575 C C9    . A1BLR C 3 .    ? 116.297 161.637 148.598 1.00 19.50  ?  1102 A1BLR C C9    1 
HETATM 6576 C C11   . A1BLR C 3 .    ? 114.834 163.266 149.849 1.00 19.50  ?  1102 A1BLR C C11   1 
HETATM 6577 C C12   . A1BLR C 3 .    ? 114.809 164.639 150.072 1.00 19.50  ?  1102 A1BLR C C12   1 
HETATM 6578 C C14   . A1BLR C 3 .    ? 112.429 164.590 150.390 1.00 19.50  ?  1102 A1BLR C C14   1 
HETATM 6579 C C16   . A1BLR C 3 .    ? 113.624 162.559 149.934 1.00 19.50  ?  1102 A1BLR C C16   1 
HETATM 6580 F F1    . A1BLR C 3 .    ? 111.127 166.531 150.203 1.00 19.50  ?  1102 A1BLR C F1    1 
HETATM 6581 F F2    . A1BLR C 3 .    ? 110.109 164.684 150.092 1.00 19.50  ?  1102 A1BLR C F2    1 
HETATM 6582 F F3    . A1BLR C 3 .    ? 110.853 165.370 151.947 1.00 19.50  ?  1102 A1BLR C F3    1 
HETATM 6583 O O     . HOH   D 4 .    ? 125.821 158.353 151.638 1.00 16.06  ?  1201 HOH   C O     1 
HETATM 6584 O O     . HOH   D 4 .    ? 114.818 159.228 158.910 1.00 26.77  ?  1202 HOH   C O     1 
HETATM 6585 O O     . HOH   D 4 .    ? 111.483 159.197 156.760 1.00 38.48  ?  1203 HOH   C O     1 
HETATM 6586 O O     . HOH   D 4 .    ? 119.939 159.745 146.071 1.00 25.48  ?  1204 HOH   C O     1 
HETATM 6587 O O     . HOH   D 4 .    ? 115.870 159.442 152.101 1.00 22.49  ?  1205 HOH   C O     1 
HETATM 6588 O O     . HOH   D 4 .    ? 118.143 156.513 153.077 1.00 20.21  ?  1206 HOH   C O     1 
HETATM 6589 O O     . HOH   D 4 .    ? 118.583 157.248 147.439 1.00 27.35  ?  1207 HOH   C O     1 
# 
