data_9MEV
# 
_entry.id   9MEV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9MEV         pdb_00009mev 10.2210/pdb9mev/pdb 
WWPDB D_1000290839 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9MEV 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bruno.correia@epfl.ch 
_pdbx_contact_author.name_first         Bruno 
_pdbx_contact_author.name_last          Correia 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7377-8636 
# 
_audit_author.name               'Seraj, N.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0002-3292-377X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.12.17.628867 
_citation.pdbx_database_id_PubMed   40027756 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Castro, K.M.'    1  0000-0002-7753-6060 
primary 'Ayardulabi, R.'  2  ?                   
primary 'Wehrle, S.'      3  ?                   
primary 'Cui, H.'         4  ?                   
primary 'Georgeon, S.'    5  ?                   
primary 'Schmidt, J.'     6  ?                   
primary 'Xiao, S.'        7  ?                   
primary 'Seraj, N.'       8  ?                   
primary 'Harshbarger, W.' 9  ?                   
primary 'Mallett, C.P.'   10 ?                   
primary 'Vassilev, V.'    11 ?                   
primary 'Saelens, X.'     12 0000-0002-3861-6965 
primary 'Correia, B.E.'   13 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'H1H3 HA'                                                                                 25737.604 1   ? ? ? ? 
2 polymer     man 'FluA20 Heavy Chain Fab'                                                                  25154.039 1   ? ? ? ? 
3 polymer     man 'FluA20 Light Chain Fab'                                                                  23508.186 1   ? ? ? ? 
4 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   1   ? ? ? ? 
5 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose                                                  221.208   1   ? ? ? ? 
6 non-polymer syn 1,2-ETHANEDIOL                                                                            62.068    6   ? ? ? ? 
7 water       nat water                                                                                     18.015    589 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;APLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHT
QNGGSNSCSHNGESSFYKNLLWLTKSGSLYPNLSKSYANNKEKEVLVLWGVHHPPTIQEQTSLYVKENAYVSVVSSHYSR
KFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGSGLVPRGSGHHHHHH
;
;APLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHT
QNGGSNSCSHNGESSFYKNLLWLTKSGSLYPNLSKSYANNKEKEVLVLWGVHHPPTIQEQTSLYVKENAYVSVVSSHYSR
KFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGSGLVPRGSGHHHHHH
;
B ? 
2 'polypeptide(L)' no no 
;QVQLEESGPGLVKPSETLSLTCSVSGVSVTSDIYYWTWIRQPPGKGLEWIGYIFYNGDTNYNPSLKSRVTMSIDTSKNEF
SLRLTSVTAADTAVYFCARGTEDLGYCSSGSCPNHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP
EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH
;
;QVQLEESGPGLVKPSETLSLTCSVSGVSVTSDIYYWTWIRQPPGKGLEWIGYIFYNGDTNYNPSLKSRVTMSIDTSKNEF
SLRLTSVTAADTAVYFCARGTEDLGYCSSGSCPNHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP
EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH
;
H ? 
3 'polypeptide(L)' no no 
;DIVMTQSPSSLSASIGDRVTITCRPSQNIRSFLNWFQHKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTEFTLTIRSLQP
EDFATYYCQQSYNTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;DIVMTQSPSSLSASIGDRVTITCRPSQNIRSFLNWFQHKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTEFTLTIRSLQP
EDFATYYCQQSYNTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
L ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
5 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
6 1,2-ETHANEDIOL                           EDO 
7 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   PRO n 
1 3   LEU n 
1 4   GLN n 
1 5   LEU n 
1 6   GLY n 
1 7   ASN n 
1 8   CYS n 
1 9   SER n 
1 10  VAL n 
1 11  ALA n 
1 12  GLY n 
1 13  TRP n 
1 14  ILE n 
1 15  LEU n 
1 16  GLY n 
1 17  ASN n 
1 18  PRO n 
1 19  GLU n 
1 20  CYS n 
1 21  GLU n 
1 22  LEU n 
1 23  LEU n 
1 24  ILE n 
1 25  SER n 
1 26  ARG n 
1 27  GLU n 
1 28  SER n 
1 29  TRP n 
1 30  SER n 
1 31  TYR n 
1 32  ILE n 
1 33  VAL n 
1 34  GLU n 
1 35  LYS n 
1 36  PRO n 
1 37  ASN n 
1 38  PRO n 
1 39  GLU n 
1 40  ASN n 
1 41  GLY n 
1 42  THR n 
1 43  CYS n 
1 44  TYR n 
1 45  PRO n 
1 46  GLY n 
1 47  HIS n 
1 48  PHE n 
1 49  ALA n 
1 50  ASP n 
1 51  TYR n 
1 52  GLU n 
1 53  GLU n 
1 54  LEU n 
1 55  ARG n 
1 56  GLU n 
1 57  GLN n 
1 58  LEU n 
1 59  SER n 
1 60  SER n 
1 61  VAL n 
1 62  SER n 
1 63  SER n 
1 64  PHE n 
1 65  GLU n 
1 66  ARG n 
1 67  PHE n 
1 68  GLU n 
1 69  ILE n 
1 70  PHE n 
1 71  PRO n 
1 72  LYS n 
1 73  GLU n 
1 74  SER n 
1 75  SER n 
1 76  TRP n 
1 77  PRO n 
1 78  ASN n 
1 79  HIS n 
1 80  THR n 
1 81  GLN n 
1 82  ASN n 
1 83  GLY n 
1 84  GLY n 
1 85  SER n 
1 86  ASN n 
1 87  SER n 
1 88  CYS n 
1 89  SER n 
1 90  HIS n 
1 91  ASN n 
1 92  GLY n 
1 93  GLU n 
1 94  SER n 
1 95  SER n 
1 96  PHE n 
1 97  TYR n 
1 98  LYS n 
1 99  ASN n 
1 100 LEU n 
1 101 LEU n 
1 102 TRP n 
1 103 LEU n 
1 104 THR n 
1 105 LYS n 
1 106 SER n 
1 107 GLY n 
1 108 SER n 
1 109 LEU n 
1 110 TYR n 
1 111 PRO n 
1 112 ASN n 
1 113 LEU n 
1 114 SER n 
1 115 LYS n 
1 116 SER n 
1 117 TYR n 
1 118 ALA n 
1 119 ASN n 
1 120 ASN n 
1 121 LYS n 
1 122 GLU n 
1 123 LYS n 
1 124 GLU n 
1 125 VAL n 
1 126 LEU n 
1 127 VAL n 
1 128 LEU n 
1 129 TRP n 
1 130 GLY n 
1 131 VAL n 
1 132 HIS n 
1 133 HIS n 
1 134 PRO n 
1 135 PRO n 
1 136 THR n 
1 137 ILE n 
1 138 GLN n 
1 139 GLU n 
1 140 GLN n 
1 141 THR n 
1 142 SER n 
1 143 LEU n 
1 144 TYR n 
1 145 VAL n 
1 146 LYS n 
1 147 GLU n 
1 148 ASN n 
1 149 ALA n 
1 150 TYR n 
1 151 VAL n 
1 152 SER n 
1 153 VAL n 
1 154 VAL n 
1 155 SER n 
1 156 SER n 
1 157 HIS n 
1 158 TYR n 
1 159 SER n 
1 160 ARG n 
1 161 LYS n 
1 162 PHE n 
1 163 THR n 
1 164 PRO n 
1 165 GLU n 
1 166 ILE n 
1 167 ALA n 
1 168 LYS n 
1 169 ARG n 
1 170 PRO n 
1 171 LYS n 
1 172 VAL n 
1 173 ARG n 
1 174 ASP n 
1 175 GLN n 
1 176 GLU n 
1 177 GLY n 
1 178 ARG n 
1 179 ILE n 
1 180 ASN n 
1 181 TYR n 
1 182 TYR n 
1 183 TRP n 
1 184 THR n 
1 185 LEU n 
1 186 LEU n 
1 187 GLU n 
1 188 PRO n 
1 189 GLY n 
1 190 ASP n 
1 191 THR n 
1 192 ILE n 
1 193 ILE n 
1 194 PHE n 
1 195 GLU n 
1 196 ALA n 
1 197 ASN n 
1 198 GLY n 
1 199 ASN n 
1 200 LEU n 
1 201 ILE n 
1 202 ALA n 
1 203 PRO n 
1 204 ARG n 
1 205 TYR n 
1 206 ALA n 
1 207 PHE n 
1 208 ALA n 
1 209 LEU n 
1 210 SER n 
1 211 ARG n 
1 212 GLY n 
1 213 SER n 
1 214 GLY n 
1 215 LEU n 
1 216 VAL n 
1 217 PRO n 
1 218 ARG n 
1 219 GLY n 
1 220 SER n 
1 221 GLY n 
1 222 HIS n 
1 223 HIS n 
1 224 HIS n 
1 225 HIS n 
1 226 HIS n 
1 227 HIS n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   GLU n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   PRO n 
2 10  GLY n 
2 11  LEU n 
2 12  VAL n 
2 13  LYS n 
2 14  PRO n 
2 15  SER n 
2 16  GLU n 
2 17  THR n 
2 18  LEU n 
2 19  SER n 
2 20  LEU n 
2 21  THR n 
2 22  CYS n 
2 23  SER n 
2 24  VAL n 
2 25  SER n 
2 26  GLY n 
2 27  VAL n 
2 28  SER n 
2 29  VAL n 
2 30  THR n 
2 31  SER n 
2 32  ASP n 
2 33  ILE n 
2 34  TYR n 
2 35  TYR n 
2 36  TRP n 
2 37  THR n 
2 38  TRP n 
2 39  ILE n 
2 40  ARG n 
2 41  GLN n 
2 42  PRO n 
2 43  PRO n 
2 44  GLY n 
2 45  LYS n 
2 46  GLY n 
2 47  LEU n 
2 48  GLU n 
2 49  TRP n 
2 50  ILE n 
2 51  GLY n 
2 52  TYR n 
2 53  ILE n 
2 54  PHE n 
2 55  TYR n 
2 56  ASN n 
2 57  GLY n 
2 58  ASP n 
2 59  THR n 
2 60  ASN n 
2 61  TYR n 
2 62  ASN n 
2 63  PRO n 
2 64  SER n 
2 65  LEU n 
2 66  LYS n 
2 67  SER n 
2 68  ARG n 
2 69  VAL n 
2 70  THR n 
2 71  MET n 
2 72  SER n 
2 73  ILE n 
2 74  ASP n 
2 75  THR n 
2 76  SER n 
2 77  LYS n 
2 78  ASN n 
2 79  GLU n 
2 80  PHE n 
2 81  SER n 
2 82  LEU n 
2 83  ARG n 
2 84  LEU n 
2 85  THR n 
2 86  SER n 
2 87  VAL n 
2 88  THR n 
2 89  ALA n 
2 90  ALA n 
2 91  ASP n 
2 92  THR n 
2 93  ALA n 
2 94  VAL n 
2 95  TYR n 
2 96  PHE n 
2 97  CYS n 
2 98  ALA n 
2 99  ARG n 
2 100 GLY n 
2 101 THR n 
2 102 GLU n 
2 103 ASP n 
2 104 LEU n 
2 105 GLY n 
2 106 TYR n 
2 107 CYS n 
2 108 SER n 
2 109 SER n 
2 110 GLY n 
2 111 SER n 
2 112 CYS n 
2 113 PRO n 
2 114 ASN n 
2 115 HIS n 
2 116 TRP n 
2 117 GLY n 
2 118 GLN n 
2 119 GLY n 
2 120 THR n 
2 121 LEU n 
2 122 VAL n 
2 123 THR n 
2 124 VAL n 
2 125 SER n 
2 126 SER n 
2 127 ALA n 
2 128 SER n 
2 129 THR n 
2 130 LYS n 
2 131 GLY n 
2 132 PRO n 
2 133 SER n 
2 134 VAL n 
2 135 PHE n 
2 136 PRO n 
2 137 LEU n 
2 138 ALA n 
2 139 PRO n 
2 140 SER n 
2 141 SER n 
2 142 LYS n 
2 143 SER n 
2 144 THR n 
2 145 SER n 
2 146 GLY n 
2 147 GLY n 
2 148 THR n 
2 149 ALA n 
2 150 ALA n 
2 151 LEU n 
2 152 GLY n 
2 153 CYS n 
2 154 LEU n 
2 155 VAL n 
2 156 LYS n 
2 157 ASP n 
2 158 TYR n 
2 159 PHE n 
2 160 PRO n 
2 161 GLU n 
2 162 PRO n 
2 163 VAL n 
2 164 THR n 
2 165 VAL n 
2 166 SER n 
2 167 TRP n 
2 168 ASN n 
2 169 SER n 
2 170 GLY n 
2 171 ALA n 
2 172 LEU n 
2 173 THR n 
2 174 SER n 
2 175 GLY n 
2 176 VAL n 
2 177 HIS n 
2 178 THR n 
2 179 PHE n 
2 180 PRO n 
2 181 ALA n 
2 182 VAL n 
2 183 LEU n 
2 184 GLN n 
2 185 SER n 
2 186 SER n 
2 187 GLY n 
2 188 LEU n 
2 189 TYR n 
2 190 SER n 
2 191 LEU n 
2 192 SER n 
2 193 SER n 
2 194 VAL n 
2 195 VAL n 
2 196 THR n 
2 197 VAL n 
2 198 PRO n 
2 199 SER n 
2 200 SER n 
2 201 SER n 
2 202 LEU n 
2 203 GLY n 
2 204 THR n 
2 205 GLN n 
2 206 THR n 
2 207 TYR n 
2 208 ILE n 
2 209 CYS n 
2 210 ASN n 
2 211 VAL n 
2 212 ASN n 
2 213 HIS n 
2 214 LYS n 
2 215 PRO n 
2 216 SER n 
2 217 ASN n 
2 218 THR n 
2 219 LYS n 
2 220 VAL n 
2 221 ASP n 
2 222 LYS n 
2 223 ARG n 
2 224 VAL n 
2 225 GLU n 
2 226 PRO n 
2 227 LYS n 
2 228 SER n 
2 229 CYS n 
2 230 HIS n 
2 231 HIS n 
2 232 HIS n 
2 233 HIS n 
2 234 HIS n 
2 235 HIS n 
3 1   ASP n 
3 2   ILE n 
3 3   VAL n 
3 4   MET n 
3 5   THR n 
3 6   GLN n 
3 7   SER n 
3 8   PRO n 
3 9   SER n 
3 10  SER n 
3 11  LEU n 
3 12  SER n 
3 13  ALA n 
3 14  SER n 
3 15  ILE n 
3 16  GLY n 
3 17  ASP n 
3 18  ARG n 
3 19  VAL n 
3 20  THR n 
3 21  ILE n 
3 22  THR n 
3 23  CYS n 
3 24  ARG n 
3 25  PRO n 
3 26  SER n 
3 27  GLN n 
3 28  ASN n 
3 29  ILE n 
3 30  ARG n 
3 31  SER n 
3 32  PHE n 
3 33  LEU n 
3 34  ASN n 
3 35  TRP n 
3 36  PHE n 
3 37  GLN n 
3 38  HIS n 
3 39  LYS n 
3 40  PRO n 
3 41  GLY n 
3 42  LYS n 
3 43  ALA n 
3 44  PRO n 
3 45  LYS n 
3 46  LEU n 
3 47  LEU n 
3 48  ILE n 
3 49  TYR n 
3 50  ALA n 
3 51  ALA n 
3 52  SER n 
3 53  ASN n 
3 54  LEU n 
3 55  GLN n 
3 56  SER n 
3 57  GLY n 
3 58  VAL n 
3 59  PRO n 
3 60  SER n 
3 61  ARG n 
3 62  PHE n 
3 63  SER n 
3 64  GLY n 
3 65  SER n 
3 66  GLY n 
3 67  SER n 
3 68  GLY n 
3 69  THR n 
3 70  GLU n 
3 71  PHE n 
3 72  THR n 
3 73  LEU n 
3 74  THR n 
3 75  ILE n 
3 76  ARG n 
3 77  SER n 
3 78  LEU n 
3 79  GLN n 
3 80  PRO n 
3 81  GLU n 
3 82  ASP n 
3 83  PHE n 
3 84  ALA n 
3 85  THR n 
3 86  TYR n 
3 87  TYR n 
3 88  CYS n 
3 89  GLN n 
3 90  GLN n 
3 91  SER n 
3 92  TYR n 
3 93  ASN n 
3 94  THR n 
3 95  PRO n 
3 96  PRO n 
3 97  THR n 
3 98  PHE n 
3 99  GLY n 
3 100 GLN n 
3 101 GLY n 
3 102 THR n 
3 103 LYS n 
3 104 VAL n 
3 105 GLU n 
3 106 ILE n 
3 107 LYS n 
3 108 ARG n 
3 109 THR n 
3 110 VAL n 
3 111 ALA n 
3 112 ALA n 
3 113 PRO n 
3 114 SER n 
3 115 VAL n 
3 116 PHE n 
3 117 ILE n 
3 118 PHE n 
3 119 PRO n 
3 120 PRO n 
3 121 SER n 
3 122 ASP n 
3 123 GLU n 
3 124 GLN n 
3 125 LEU n 
3 126 LYS n 
3 127 SER n 
3 128 GLY n 
3 129 THR n 
3 130 ALA n 
3 131 SER n 
3 132 VAL n 
3 133 VAL n 
3 134 CYS n 
3 135 LEU n 
3 136 LEU n 
3 137 ASN n 
3 138 ASN n 
3 139 PHE n 
3 140 TYR n 
3 141 PRO n 
3 142 ARG n 
3 143 GLU n 
3 144 ALA n 
3 145 LYS n 
3 146 VAL n 
3 147 GLN n 
3 148 TRP n 
3 149 LYS n 
3 150 VAL n 
3 151 ASP n 
3 152 ASN n 
3 153 ALA n 
3 154 LEU n 
3 155 GLN n 
3 156 SER n 
3 157 GLY n 
3 158 ASN n 
3 159 SER n 
3 160 GLN n 
3 161 GLU n 
3 162 SER n 
3 163 VAL n 
3 164 THR n 
3 165 GLU n 
3 166 GLN n 
3 167 ASP n 
3 168 SER n 
3 169 LYS n 
3 170 ASP n 
3 171 SER n 
3 172 THR n 
3 173 TYR n 
3 174 SER n 
3 175 LEU n 
3 176 SER n 
3 177 SER n 
3 178 THR n 
3 179 LEU n 
3 180 THR n 
3 181 LEU n 
3 182 SER n 
3 183 LYS n 
3 184 ALA n 
3 185 ASP n 
3 186 TYR n 
3 187 GLU n 
3 188 LYS n 
3 189 HIS n 
3 190 LYS n 
3 191 VAL n 
3 192 TYR n 
3 193 ALA n 
3 194 CYS n 
3 195 GLU n 
3 196 VAL n 
3 197 THR n 
3 198 HIS n 
3 199 GLN n 
3 200 GLY n 
3 201 LEU n 
3 202 SER n 
3 203 SER n 
3 204 PRO n 
3 205 VAL n 
3 206 THR n 
3 207 LYS n 
3 208 SER n 
3 209 PHE n 
3 210 ASN n 
3 211 ARG n 
3 212 GLY n 
3 213 GLU n 
3 214 CYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 227 ?     ? ? ? ? ? ? ? ? 'Influenza A virus' 11320 ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 235 human ? ? ? ? ? ? ? ? 'Homo sapiens'      9606  ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 214 human ? ? ? ? ? ? ? ? 'Homo sapiens'      9606  ? ? ? ? ? ? ? human 'Homo sapiens' 9606 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   4 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 4 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 4 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 4 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  4 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
EDO non-polymer                  . 1,2-ETHANEDIOL                           'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   52  52  ALA ALA B . n 
A 1 2   PRO 2   53  53  PRO PRO B . n 
A 1 3   LEU 3   54  54  LEU LEU B . n 
A 1 4   GLN 4   55  55  GLN GLN B . n 
A 1 5   LEU 5   56  56  LEU LEU B . n 
A 1 6   GLY 6   57  57  GLY GLY B . n 
A 1 7   ASN 7   58  58  ASN ASN B . n 
A 1 8   CYS 8   59  59  CYS CYS B . n 
A 1 9   SER 9   60  60  SER SER B . n 
A 1 10  VAL 10  61  61  VAL VAL B . n 
A 1 11  ALA 11  62  62  ALA ALA B . n 
A 1 12  GLY 12  63  63  GLY GLY B . n 
A 1 13  TRP 13  64  64  TRP TRP B . n 
A 1 14  ILE 14  65  65  ILE ILE B . n 
A 1 15  LEU 15  66  66  LEU LEU B . n 
A 1 16  GLY 16  67  67  GLY GLY B . n 
A 1 17  ASN 17  68  68  ASN ASN B . n 
A 1 18  PRO 18  69  69  PRO PRO B . n 
A 1 19  GLU 19  70  70  GLU GLU B . n 
A 1 20  CYS 20  71  71  CYS CYS B . n 
A 1 21  GLU 21  72  72  GLU GLU B . n 
A 1 22  LEU 22  73  73  LEU LEU B . n 
A 1 23  LEU 23  74  74  LEU LEU B . n 
A 1 24  ILE 24  75  75  ILE ILE B . n 
A 1 25  SER 25  76  76  SER SER B . n 
A 1 26  ARG 26  77  77  ARG ARG B . n 
A 1 27  GLU 27  78  78  GLU GLU B . n 
A 1 28  SER 28  79  79  SER SER B . n 
A 1 29  TRP 29  80  80  TRP TRP B . n 
A 1 30  SER 30  81  81  SER SER B . n 
A 1 31  TYR 31  82  82  TYR TYR B . n 
A 1 32  ILE 32  83  83  ILE ILE B . n 
A 1 33  VAL 33  84  84  VAL VAL B . n 
A 1 34  GLU 34  85  85  GLU GLU B . n 
A 1 35  LYS 35  86  86  LYS LYS B . n 
A 1 36  PRO 36  87  87  PRO PRO B . n 
A 1 37  ASN 37  88  88  ASN ASN B . n 
A 1 38  PRO 38  89  89  PRO PRO B . n 
A 1 39  GLU 39  90  90  GLU GLU B . n 
A 1 40  ASN 40  91  91  ASN ASN B . n 
A 1 41  GLY 41  92  92  GLY GLY B . n 
A 1 42  THR 42  93  93  THR THR B . n 
A 1 43  CYS 43  94  94  CYS CYS B . n 
A 1 44  TYR 44  95  95  TYR TYR B . n 
A 1 45  PRO 45  96  96  PRO PRO B . n 
A 1 46  GLY 46  97  97  GLY GLY B . n 
A 1 47  HIS 47  98  98  HIS HIS B . n 
A 1 48  PHE 48  99  99  PHE PHE B . n 
A 1 49  ALA 49  100 100 ALA ALA B . n 
A 1 50  ASP 50  101 101 ASP ASP B . n 
A 1 51  TYR 51  102 102 TYR TYR B . n 
A 1 52  GLU 52  103 103 GLU GLU B . n 
A 1 53  GLU 53  104 104 GLU GLU B . n 
A 1 54  LEU 54  105 105 LEU LEU B . n 
A 1 55  ARG 55  106 106 ARG ARG B . n 
A 1 56  GLU 56  107 107 GLU GLU B . n 
A 1 57  GLN 57  108 108 GLN GLN B . n 
A 1 58  LEU 58  109 109 LEU LEU B . n 
A 1 59  SER 59  110 110 SER SER B . n 
A 1 60  SER 60  111 111 SER SER B . n 
A 1 61  VAL 61  112 112 VAL VAL B . n 
A 1 62  SER 62  113 113 SER SER B . n 
A 1 63  SER 63  114 114 SER SER B . n 
A 1 64  PHE 64  115 115 PHE PHE B . n 
A 1 65  GLU 65  116 116 GLU GLU B . n 
A 1 66  ARG 66  117 117 ARG ARG B . n 
A 1 67  PHE 67  118 118 PHE PHE B . n 
A 1 68  GLU 68  119 119 GLU GLU B . n 
A 1 69  ILE 69  120 120 ILE ILE B . n 
A 1 70  PHE 70  121 121 PHE PHE B . n 
A 1 71  PRO 71  122 122 PRO PRO B . n 
A 1 72  LYS 72  123 123 LYS LYS B . n 
A 1 73  GLU 73  124 124 GLU GLU B . n 
A 1 74  SER 74  125 125 SER SER B . n 
A 1 75  SER 75  126 126 SER SER B . n 
A 1 76  TRP 76  127 127 TRP TRP B . n 
A 1 77  PRO 77  128 128 PRO PRO B . n 
A 1 78  ASN 78  129 129 ASN ASN B . n 
A 1 79  HIS 79  130 130 HIS HIS B . n 
A 1 80  THR 80  131 131 THR THR B . n 
A 1 81  GLN 81  132 132 GLN GLN B . n 
A 1 82  ASN 82  133 133 ASN ASN B . n 
A 1 83  GLY 83  134 134 GLY GLY B . n 
A 1 84  GLY 84  135 135 GLY GLY B . n 
A 1 85  SER 85  136 136 SER SER B . n 
A 1 86  ASN 86  137 137 ASN ASN B . n 
A 1 87  SER 87  138 138 SER SER B . n 
A 1 88  CYS 88  139 139 CYS CYS B . n 
A 1 89  SER 89  140 140 SER SER B . n 
A 1 90  HIS 90  141 141 HIS HIS B . n 
A 1 91  ASN 91  142 142 ASN ASN B . n 
A 1 92  GLY 92  143 143 GLY GLY B . n 
A 1 93  GLU 93  144 144 GLU GLU B . n 
A 1 94  SER 94  145 145 SER SER B . n 
A 1 95  SER 95  146 146 SER SER B . n 
A 1 96  PHE 96  147 147 PHE PHE B . n 
A 1 97  TYR 97  148 148 TYR TYR B . n 
A 1 98  LYS 98  149 149 LYS LYS B . n 
A 1 99  ASN 99  150 150 ASN ASN B . n 
A 1 100 LEU 100 151 151 LEU LEU B . n 
A 1 101 LEU 101 152 152 LEU LEU B . n 
A 1 102 TRP 102 153 153 TRP TRP B . n 
A 1 103 LEU 103 154 154 LEU LEU B . n 
A 1 104 THR 104 155 155 THR THR B . n 
A 1 105 LYS 105 156 156 LYS LYS B . n 
A 1 106 SER 106 157 157 SER SER B . n 
A 1 107 GLY 107 158 158 GLY GLY B . n 
A 1 108 SER 108 159 159 SER SER B . n 
A 1 109 LEU 109 160 160 LEU LEU B . n 
A 1 110 TYR 110 161 161 TYR TYR B . n 
A 1 111 PRO 111 162 162 PRO PRO B . n 
A 1 112 ASN 112 163 163 ASN ASN B . n 
A 1 113 LEU 113 164 164 LEU LEU B . n 
A 1 114 SER 114 165 165 SER SER B . n 
A 1 115 LYS 115 166 166 LYS LYS B . n 
A 1 116 SER 116 167 167 SER SER B . n 
A 1 117 TYR 117 168 168 TYR TYR B . n 
A 1 118 ALA 118 169 169 ALA ALA B . n 
A 1 119 ASN 119 170 170 ASN ASN B . n 
A 1 120 ASN 120 171 171 ASN ASN B . n 
A 1 121 LYS 121 172 172 LYS LYS B . n 
A 1 122 GLU 122 173 173 GLU GLU B . n 
A 1 123 LYS 123 174 174 LYS LYS B . n 
A 1 124 GLU 124 175 175 GLU GLU B . n 
A 1 125 VAL 125 176 176 VAL VAL B . n 
A 1 126 LEU 126 177 177 LEU LEU B . n 
A 1 127 VAL 127 178 178 VAL VAL B . n 
A 1 128 LEU 128 179 179 LEU LEU B . n 
A 1 129 TRP 129 180 180 TRP TRP B . n 
A 1 130 GLY 130 181 181 GLY GLY B . n 
A 1 131 VAL 131 182 182 VAL VAL B . n 
A 1 132 HIS 132 183 183 HIS HIS B . n 
A 1 133 HIS 133 184 184 HIS HIS B . n 
A 1 134 PRO 134 185 185 PRO PRO B . n 
A 1 135 PRO 135 186 186 PRO PRO B . n 
A 1 136 THR 136 187 187 THR THR B . n 
A 1 137 ILE 137 188 188 ILE ILE B . n 
A 1 138 GLN 138 189 189 GLN GLN B . n 
A 1 139 GLU 139 190 190 GLU GLU B . n 
A 1 140 GLN 140 191 191 GLN GLN B . n 
A 1 141 THR 141 192 192 THR THR B . n 
A 1 142 SER 142 193 193 SER SER B . n 
A 1 143 LEU 143 194 194 LEU LEU B . n 
A 1 144 TYR 144 195 195 TYR TYR B . n 
A 1 145 VAL 145 196 196 VAL VAL B . n 
A 1 146 LYS 146 197 197 LYS LYS B . n 
A 1 147 GLU 147 198 198 GLU GLU B . n 
A 1 148 ASN 148 199 199 ASN ASN B . n 
A 1 149 ALA 149 200 200 ALA ALA B . n 
A 1 150 TYR 150 201 201 TYR TYR B . n 
A 1 151 VAL 151 202 202 VAL VAL B . n 
A 1 152 SER 152 203 203 SER SER B . n 
A 1 153 VAL 153 204 204 VAL VAL B . n 
A 1 154 VAL 154 205 205 VAL VAL B . n 
A 1 155 SER 155 206 206 SER SER B . n 
A 1 156 SER 156 207 207 SER SER B . n 
A 1 157 HIS 157 208 208 HIS HIS B . n 
A 1 158 TYR 158 209 209 TYR TYR B . n 
A 1 159 SER 159 210 210 SER SER B . n 
A 1 160 ARG 160 211 211 ARG ARG B . n 
A 1 161 LYS 161 212 212 LYS LYS B . n 
A 1 162 PHE 162 213 213 PHE PHE B . n 
A 1 163 THR 163 214 214 THR THR B . n 
A 1 164 PRO 164 215 215 PRO PRO B . n 
A 1 165 GLU 165 216 216 GLU GLU B . n 
A 1 166 ILE 166 217 217 ILE ILE B . n 
A 1 167 ALA 167 218 218 ALA ALA B . n 
A 1 168 LYS 168 219 219 LYS LYS B . n 
A 1 169 ARG 169 220 220 ARG ARG B . n 
A 1 170 PRO 170 221 221 PRO PRO B . n 
A 1 171 LYS 171 222 222 LYS LYS B . n 
A 1 172 VAL 172 223 223 VAL VAL B . n 
A 1 173 ARG 173 224 224 ARG ARG B . n 
A 1 174 ASP 174 225 225 ASP ASP B . n 
A 1 175 GLN 175 226 226 GLN GLN B . n 
A 1 176 GLU 176 227 227 GLU GLU B . n 
A 1 177 GLY 177 228 228 GLY GLY B . n 
A 1 178 ARG 178 229 229 ARG ARG B . n 
A 1 179 ILE 179 230 230 ILE ILE B . n 
A 1 180 ASN 180 231 231 ASN ASN B . n 
A 1 181 TYR 181 232 232 TYR TYR B . n 
A 1 182 TYR 182 233 233 TYR TYR B . n 
A 1 183 TRP 183 234 234 TRP TRP B . n 
A 1 184 THR 184 235 235 THR THR B . n 
A 1 185 LEU 185 236 236 LEU LEU B . n 
A 1 186 LEU 186 237 237 LEU LEU B . n 
A 1 187 GLU 187 238 238 GLU GLU B . n 
A 1 188 PRO 188 239 239 PRO PRO B . n 
A 1 189 GLY 189 240 240 GLY GLY B . n 
A 1 190 ASP 190 241 241 ASP ASP B . n 
A 1 191 THR 191 242 242 THR THR B . n 
A 1 192 ILE 192 243 243 ILE ILE B . n 
A 1 193 ILE 193 244 244 ILE ILE B . n 
A 1 194 PHE 194 245 245 PHE PHE B . n 
A 1 195 GLU 195 246 246 GLU GLU B . n 
A 1 196 ALA 196 247 247 ALA ALA B . n 
A 1 197 ASN 197 248 248 ASN ASN B . n 
A 1 198 GLY 198 249 249 GLY GLY B . n 
A 1 199 ASN 199 250 250 ASN ASN B . n 
A 1 200 LEU 200 251 251 LEU LEU B . n 
A 1 201 ILE 201 252 252 ILE ILE B . n 
A 1 202 ALA 202 253 253 ALA ALA B . n 
A 1 203 PRO 203 254 254 PRO PRO B . n 
A 1 204 ARG 204 255 255 ARG ARG B . n 
A 1 205 TYR 205 256 256 TYR TYR B . n 
A 1 206 ALA 206 257 257 ALA ALA B . n 
A 1 207 PHE 207 258 258 PHE PHE B . n 
A 1 208 ALA 208 259 259 ALA ALA B . n 
A 1 209 LEU 209 260 260 LEU LEU B . n 
A 1 210 SER 210 261 261 SER SER B . n 
A 1 211 ARG 211 262 262 ARG ARG B . n 
A 1 212 GLY 212 263 263 GLY GLY B . n 
A 1 213 SER 213 264 ?   ?   ?   B . n 
A 1 214 GLY 214 265 ?   ?   ?   B . n 
A 1 215 LEU 215 266 ?   ?   ?   B . n 
A 1 216 VAL 216 267 ?   ?   ?   B . n 
A 1 217 PRO 217 268 ?   ?   ?   B . n 
A 1 218 ARG 218 269 ?   ?   ?   B . n 
A 1 219 GLY 219 270 ?   ?   ?   B . n 
A 1 220 SER 220 271 ?   ?   ?   B . n 
A 1 221 GLY 221 272 ?   ?   ?   B . n 
A 1 222 HIS 222 273 ?   ?   ?   B . n 
A 1 223 HIS 223 274 ?   ?   ?   B . n 
A 1 224 HIS 224 275 ?   ?   ?   B . n 
A 1 225 HIS 225 276 ?   ?   ?   B . n 
A 1 226 HIS 226 277 ?   ?   ?   B . n 
A 1 227 HIS 227 278 ?   ?   ?   B . n 
B 2 1   GLN 1   1   1   GLN GLN H . n 
B 2 2   VAL 2   2   2   VAL VAL H . n 
B 2 3   GLN 3   3   3   GLN GLN H . n 
B 2 4   LEU 4   4   4   LEU LEU H . n 
B 2 5   GLU 5   5   5   GLU GLU H . n 
B 2 6   GLU 6   6   6   GLU GLU H . n 
B 2 7   SER 7   7   7   SER SER H . n 
B 2 8   GLY 8   8   8   GLY GLY H . n 
B 2 9   PRO 9   9   9   PRO PRO H . n 
B 2 10  GLY 10  10  10  GLY GLY H . n 
B 2 11  LEU 11  11  11  LEU LEU H . n 
B 2 12  VAL 12  12  12  VAL VAL H . n 
B 2 13  LYS 13  13  13  LYS LYS H . n 
B 2 14  PRO 14  14  14  PRO PRO H . n 
B 2 15  SER 15  15  15  SER SER H . n 
B 2 16  GLU 16  16  16  GLU GLU H . n 
B 2 17  THR 17  17  17  THR THR H . n 
B 2 18  LEU 18  18  18  LEU LEU H . n 
B 2 19  SER 19  19  19  SER SER H . n 
B 2 20  LEU 20  20  20  LEU LEU H . n 
B 2 21  THR 21  21  21  THR THR H . n 
B 2 22  CYS 22  22  22  CYS CYS H . n 
B 2 23  SER 23  23  23  SER SER H . n 
B 2 24  VAL 24  24  24  VAL VAL H . n 
B 2 25  SER 25  25  25  SER SER H . n 
B 2 26  GLY 26  26  26  GLY GLY H . n 
B 2 27  VAL 27  27  27  VAL VAL H . n 
B 2 28  SER 28  28  28  SER SER H . n 
B 2 29  VAL 29  29  29  VAL VAL H . n 
B 2 30  THR 30  30  30  THR THR H . n 
B 2 31  SER 31  31  31  SER SER H . n 
B 2 32  ASP 32  32  32  ASP ASP H . n 
B 2 33  ILE 33  33  33  ILE ILE H . n 
B 2 34  TYR 34  34  34  TYR TYR H . n 
B 2 35  TYR 35  35  35  TYR TYR H . n 
B 2 36  TRP 36  35  35  TRP TRP H A n 
B 2 37  THR 37  35  35  THR THR H B n 
B 2 38  TRP 38  36  36  TRP TRP H . n 
B 2 39  ILE 39  37  37  ILE ILE H . n 
B 2 40  ARG 40  38  38  ARG ARG H . n 
B 2 41  GLN 41  39  39  GLN GLN H . n 
B 2 42  PRO 42  40  40  PRO PRO H . n 
B 2 43  PRO 43  41  41  PRO PRO H . n 
B 2 44  GLY 44  42  42  GLY GLY H . n 
B 2 45  LYS 45  43  43  LYS LYS H . n 
B 2 46  GLY 46  44  44  GLY GLY H . n 
B 2 47  LEU 47  45  45  LEU LEU H . n 
B 2 48  GLU 48  46  46  GLU GLU H . n 
B 2 49  TRP 49  47  47  TRP TRP H . n 
B 2 50  ILE 50  48  48  ILE ILE H . n 
B 2 51  GLY 51  49  49  GLY GLY H . n 
B 2 52  TYR 52  50  50  TYR TYR H . n 
B 2 53  ILE 53  51  51  ILE ILE H . n 
B 2 54  PHE 54  52  52  PHE PHE H . n 
B 2 55  TYR 55  53  53  TYR TYR H . n 
B 2 56  ASN 56  54  54  ASN ASN H . n 
B 2 57  GLY 57  55  55  GLY GLY H . n 
B 2 58  ASP 58  56  56  ASP ASP H . n 
B 2 59  THR 59  57  57  THR THR H . n 
B 2 60  ASN 60  58  58  ASN ASN H . n 
B 2 61  TYR 61  59  59  TYR TYR H . n 
B 2 62  ASN 62  60  60  ASN ASN H . n 
B 2 63  PRO 63  61  61  PRO PRO H . n 
B 2 64  SER 64  62  62  SER SER H . n 
B 2 65  LEU 65  63  63  LEU LEU H . n 
B 2 66  LYS 66  64  64  LYS LYS H . n 
B 2 67  SER 67  65  65  SER SER H . n 
B 2 68  ARG 68  66  66  ARG ARG H . n 
B 2 69  VAL 69  67  67  VAL VAL H . n 
B 2 70  THR 70  68  68  THR THR H . n 
B 2 71  MET 71  69  69  MET MET H . n 
B 2 72  SER 72  70  70  SER SER H . n 
B 2 73  ILE 73  71  71  ILE ILE H . n 
B 2 74  ASP 74  72  72  ASP ASP H . n 
B 2 75  THR 75  73  73  THR THR H . n 
B 2 76  SER 76  74  74  SER SER H . n 
B 2 77  LYS 77  75  75  LYS LYS H . n 
B 2 78  ASN 78  76  76  ASN ASN H . n 
B 2 79  GLU 79  77  77  GLU GLU H . n 
B 2 80  PHE 80  78  78  PHE PHE H . n 
B 2 81  SER 81  79  79  SER SER H . n 
B 2 82  LEU 82  80  80  LEU LEU H . n 
B 2 83  ARG 83  81  81  ARG ARG H . n 
B 2 84  LEU 84  82  82  LEU LEU H . n 
B 2 85  THR 85  82  82  THR THR H A n 
B 2 86  SER 86  82  82  SER SER H B n 
B 2 87  VAL 87  82  82  VAL VAL H C n 
B 2 88  THR 88  83  83  THR THR H . n 
B 2 89  ALA 89  84  84  ALA ALA H . n 
B 2 90  ALA 90  85  85  ALA ALA H . n 
B 2 91  ASP 91  86  86  ASP ASP H . n 
B 2 92  THR 92  87  87  THR THR H . n 
B 2 93  ALA 93  88  88  ALA ALA H . n 
B 2 94  VAL 94  89  89  VAL VAL H . n 
B 2 95  TYR 95  90  90  TYR TYR H . n 
B 2 96  PHE 96  91  91  PHE PHE H . n 
B 2 97  CYS 97  92  92  CYS CYS H . n 
B 2 98  ALA 98  93  93  ALA ALA H . n 
B 2 99  ARG 99  94  94  ARG ARG H . n 
B 2 100 GLY 100 95  95  GLY GLY H . n 
B 2 101 THR 101 96  96  THR THR H . n 
B 2 102 GLU 102 97  97  GLU GLU H . n 
B 2 103 ASP 103 98  98  ASP ASP H . n 
B 2 104 LEU 104 99  99  LEU LEU H . n 
B 2 105 GLY 105 100 100 GLY GLY H . n 
B 2 106 TYR 106 100 100 TYR TYR H A n 
B 2 107 CYS 107 100 100 CYS CYS H B n 
B 2 108 SER 108 100 100 SER SER H C n 
B 2 109 SER 109 100 100 SER SER H D n 
B 2 110 GLY 110 100 100 GLY GLY H E n 
B 2 111 SER 111 100 100 SER SER H F n 
B 2 112 CYS 112 100 100 CYS CYS H G n 
B 2 113 PRO 113 100 100 PRO PRO H H n 
B 2 114 ASN 114 101 101 ASN ASN H . n 
B 2 115 HIS 115 102 102 HIS HIS H . n 
B 2 116 TRP 116 103 103 TRP TRP H . n 
B 2 117 GLY 117 104 104 GLY GLY H . n 
B 2 118 GLN 118 105 105 GLN GLN H . n 
B 2 119 GLY 119 106 106 GLY GLY H . n 
B 2 120 THR 120 107 107 THR THR H . n 
B 2 121 LEU 121 108 108 LEU LEU H . n 
B 2 122 VAL 122 109 109 VAL VAL H . n 
B 2 123 THR 123 110 110 THR THR H . n 
B 2 124 VAL 124 111 111 VAL VAL H . n 
B 2 125 SER 125 112 112 SER SER H . n 
B 2 126 SER 126 113 113 SER SER H . n 
B 2 127 ALA 127 114 114 ALA ALA H . n 
B 2 128 SER 128 115 115 SER SER H . n 
B 2 129 THR 129 116 116 THR THR H . n 
B 2 130 LYS 130 117 117 LYS LYS H . n 
B 2 131 GLY 131 118 118 GLY GLY H . n 
B 2 132 PRO 132 119 119 PRO PRO H . n 
B 2 133 SER 133 120 120 SER SER H . n 
B 2 134 VAL 134 121 121 VAL VAL H . n 
B 2 135 PHE 135 122 122 PHE PHE H . n 
B 2 136 PRO 136 123 123 PRO PRO H . n 
B 2 137 LEU 137 124 124 LEU LEU H . n 
B 2 138 ALA 138 125 125 ALA ALA H . n 
B 2 139 PRO 139 126 126 PRO PRO H . n 
B 2 140 SER 140 127 127 SER SER H . n 
B 2 141 SER 141 128 128 SER SER H . n 
B 2 142 LYS 142 129 129 LYS LYS H . n 
B 2 143 SER 143 130 130 SER SER H . n 
B 2 144 THR 144 131 131 THR THR H . n 
B 2 145 SER 145 132 132 SER SER H . n 
B 2 146 GLY 146 133 133 GLY GLY H . n 
B 2 147 GLY 147 134 134 GLY GLY H . n 
B 2 148 THR 148 135 135 THR THR H . n 
B 2 149 ALA 149 136 136 ALA ALA H . n 
B 2 150 ALA 150 137 137 ALA ALA H . n 
B 2 151 LEU 151 138 138 LEU LEU H . n 
B 2 152 GLY 152 139 139 GLY GLY H . n 
B 2 153 CYS 153 140 140 CYS CYS H . n 
B 2 154 LEU 154 141 141 LEU LEU H . n 
B 2 155 VAL 155 142 142 VAL VAL H . n 
B 2 156 LYS 156 143 143 LYS LYS H . n 
B 2 157 ASP 157 144 144 ASP ASP H . n 
B 2 158 TYR 158 145 145 TYR TYR H . n 
B 2 159 PHE 159 146 146 PHE PHE H . n 
B 2 160 PRO 160 147 147 PRO PRO H . n 
B 2 161 GLU 161 148 148 GLU GLU H . n 
B 2 162 PRO 162 149 149 PRO PRO H . n 
B 2 163 VAL 163 150 150 VAL VAL H . n 
B 2 164 THR 164 151 151 THR THR H . n 
B 2 165 VAL 165 152 152 VAL VAL H . n 
B 2 166 SER 166 153 153 SER SER H . n 
B 2 167 TRP 167 154 154 TRP TRP H . n 
B 2 168 ASN 168 155 155 ASN ASN H . n 
B 2 169 SER 169 156 156 SER SER H . n 
B 2 170 GLY 170 157 157 GLY GLY H . n 
B 2 171 ALA 171 158 158 ALA ALA H . n 
B 2 172 LEU 172 159 159 LEU LEU H . n 
B 2 173 THR 173 160 160 THR THR H . n 
B 2 174 SER 174 161 161 SER SER H . n 
B 2 175 GLY 175 162 162 GLY GLY H . n 
B 2 176 VAL 176 163 163 VAL VAL H . n 
B 2 177 HIS 177 164 164 HIS HIS H . n 
B 2 178 THR 178 165 165 THR THR H . n 
B 2 179 PHE 179 166 166 PHE PHE H . n 
B 2 180 PRO 180 167 167 PRO PRO H . n 
B 2 181 ALA 181 168 168 ALA ALA H . n 
B 2 182 VAL 182 169 169 VAL VAL H . n 
B 2 183 LEU 183 170 170 LEU LEU H . n 
B 2 184 GLN 184 171 171 GLN GLN H . n 
B 2 185 SER 185 172 172 SER SER H . n 
B 2 186 SER 186 173 173 SER SER H . n 
B 2 187 GLY 187 174 174 GLY GLY H . n 
B 2 188 LEU 188 175 175 LEU LEU H . n 
B 2 189 TYR 189 176 176 TYR TYR H . n 
B 2 190 SER 190 177 177 SER SER H . n 
B 2 191 LEU 191 178 178 LEU LEU H . n 
B 2 192 SER 192 179 179 SER SER H . n 
B 2 193 SER 193 180 180 SER SER H . n 
B 2 194 VAL 194 181 181 VAL VAL H . n 
B 2 195 VAL 195 182 182 VAL VAL H . n 
B 2 196 THR 196 183 183 THR THR H . n 
B 2 197 VAL 197 184 184 VAL VAL H . n 
B 2 198 PRO 198 185 185 PRO PRO H . n 
B 2 199 SER 199 186 186 SER SER H . n 
B 2 200 SER 200 187 187 SER SER H . n 
B 2 201 SER 201 188 188 SER SER H . n 
B 2 202 LEU 202 189 189 LEU LEU H . n 
B 2 203 GLY 203 190 190 GLY GLY H . n 
B 2 204 THR 204 191 191 THR THR H . n 
B 2 205 GLN 205 192 192 GLN GLN H . n 
B 2 206 THR 206 193 193 THR THR H . n 
B 2 207 TYR 207 194 194 TYR TYR H . n 
B 2 208 ILE 208 195 195 ILE ILE H . n 
B 2 209 CYS 209 196 196 CYS CYS H . n 
B 2 210 ASN 210 197 197 ASN ASN H . n 
B 2 211 VAL 211 198 198 VAL VAL H . n 
B 2 212 ASN 212 199 199 ASN ASN H . n 
B 2 213 HIS 213 200 200 HIS HIS H . n 
B 2 214 LYS 214 201 201 LYS LYS H . n 
B 2 215 PRO 215 202 202 PRO PRO H . n 
B 2 216 SER 216 203 203 SER SER H . n 
B 2 217 ASN 217 204 204 ASN ASN H . n 
B 2 218 THR 218 205 205 THR THR H . n 
B 2 219 LYS 219 206 206 LYS LYS H . n 
B 2 220 VAL 220 207 207 VAL VAL H . n 
B 2 221 ASP 221 208 208 ASP ASP H . n 
B 2 222 LYS 222 209 209 LYS LYS H . n 
B 2 223 ARG 223 210 210 ARG ARG H . n 
B 2 224 VAL 224 211 211 VAL VAL H . n 
B 2 225 GLU 225 212 212 GLU GLU H . n 
B 2 226 PRO 226 213 213 PRO PRO H . n 
B 2 227 LYS 227 214 214 LYS LYS H . n 
B 2 228 SER 228 215 ?   ?   ?   H . n 
B 2 229 CYS 229 216 ?   ?   ?   H . n 
B 2 230 HIS 230 217 ?   ?   ?   H . n 
B 2 231 HIS 231 218 ?   ?   ?   H . n 
B 2 232 HIS 232 219 ?   ?   ?   H . n 
B 2 233 HIS 233 220 ?   ?   ?   H . n 
B 2 234 HIS 234 221 ?   ?   ?   H . n 
B 2 235 HIS 235 222 ?   ?   ?   H . n 
C 3 1   ASP 1   1   1   ASP ASP L . n 
C 3 2   ILE 2   2   2   ILE ILE L . n 
C 3 3   VAL 3   3   3   VAL VAL L . n 
C 3 4   MET 4   4   4   MET MET L . n 
C 3 5   THR 5   5   5   THR THR L . n 
C 3 6   GLN 6   6   6   GLN GLN L . n 
C 3 7   SER 7   7   7   SER SER L . n 
C 3 8   PRO 8   8   8   PRO PRO L . n 
C 3 9   SER 9   9   9   SER SER L . n 
C 3 10  SER 10  10  10  SER SER L . n 
C 3 11  LEU 11  11  11  LEU LEU L . n 
C 3 12  SER 12  12  12  SER SER L . n 
C 3 13  ALA 13  13  13  ALA ALA L . n 
C 3 14  SER 14  14  14  SER SER L . n 
C 3 15  ILE 15  15  15  ILE ILE L . n 
C 3 16  GLY 16  16  16  GLY GLY L . n 
C 3 17  ASP 17  17  17  ASP ASP L . n 
C 3 18  ARG 18  18  18  ARG ARG L . n 
C 3 19  VAL 19  19  19  VAL VAL L . n 
C 3 20  THR 20  20  20  THR THR L . n 
C 3 21  ILE 21  21  21  ILE ILE L . n 
C 3 22  THR 22  22  22  THR THR L . n 
C 3 23  CYS 23  23  23  CYS CYS L . n 
C 3 24  ARG 24  24  24  ARG ARG L . n 
C 3 25  PRO 25  25  25  PRO PRO L . n 
C 3 26  SER 26  26  26  SER SER L . n 
C 3 27  GLN 27  27  27  GLN GLN L . n 
C 3 28  ASN 28  28  28  ASN ASN L . n 
C 3 29  ILE 29  29  29  ILE ILE L . n 
C 3 30  ARG 30  30  30  ARG ARG L . n 
C 3 31  SER 31  31  31  SER SER L . n 
C 3 32  PHE 32  32  32  PHE PHE L . n 
C 3 33  LEU 33  33  33  LEU LEU L . n 
C 3 34  ASN 34  34  34  ASN ASN L . n 
C 3 35  TRP 35  35  35  TRP TRP L . n 
C 3 36  PHE 36  36  36  PHE PHE L . n 
C 3 37  GLN 37  37  37  GLN GLN L . n 
C 3 38  HIS 38  38  38  HIS HIS L . n 
C 3 39  LYS 39  39  39  LYS LYS L . n 
C 3 40  PRO 40  40  40  PRO PRO L . n 
C 3 41  GLY 41  41  41  GLY GLY L . n 
C 3 42  LYS 42  42  42  LYS LYS L . n 
C 3 43  ALA 43  43  43  ALA ALA L . n 
C 3 44  PRO 44  44  44  PRO PRO L . n 
C 3 45  LYS 45  45  45  LYS LYS L . n 
C 3 46  LEU 46  46  46  LEU LEU L . n 
C 3 47  LEU 47  47  47  LEU LEU L . n 
C 3 48  ILE 48  48  48  ILE ILE L . n 
C 3 49  TYR 49  49  49  TYR TYR L . n 
C 3 50  ALA 50  50  50  ALA ALA L . n 
C 3 51  ALA 51  51  51  ALA ALA L . n 
C 3 52  SER 52  52  52  SER SER L . n 
C 3 53  ASN 53  53  53  ASN ASN L . n 
C 3 54  LEU 54  54  54  LEU LEU L . n 
C 3 55  GLN 55  55  55  GLN GLN L . n 
C 3 56  SER 56  56  56  SER SER L . n 
C 3 57  GLY 57  57  57  GLY GLY L . n 
C 3 58  VAL 58  58  58  VAL VAL L . n 
C 3 59  PRO 59  59  59  PRO PRO L . n 
C 3 60  SER 60  60  60  SER SER L . n 
C 3 61  ARG 61  61  61  ARG ARG L . n 
C 3 62  PHE 62  62  62  PHE PHE L . n 
C 3 63  SER 63  63  63  SER SER L . n 
C 3 64  GLY 64  64  64  GLY GLY L . n 
C 3 65  SER 65  65  65  SER SER L . n 
C 3 66  GLY 66  66  66  GLY GLY L . n 
C 3 67  SER 67  67  67  SER SER L . n 
C 3 68  GLY 68  68  68  GLY GLY L . n 
C 3 69  THR 69  69  69  THR THR L . n 
C 3 70  GLU 70  70  70  GLU GLU L . n 
C 3 71  PHE 71  71  71  PHE PHE L . n 
C 3 72  THR 72  72  72  THR THR L . n 
C 3 73  LEU 73  73  73  LEU LEU L . n 
C 3 74  THR 74  74  74  THR THR L . n 
C 3 75  ILE 75  75  75  ILE ILE L . n 
C 3 76  ARG 76  76  76  ARG ARG L . n 
C 3 77  SER 77  77  77  SER SER L . n 
C 3 78  LEU 78  78  78  LEU LEU L . n 
C 3 79  GLN 79  79  79  GLN GLN L . n 
C 3 80  PRO 80  80  80  PRO PRO L . n 
C 3 81  GLU 81  81  81  GLU GLU L . n 
C 3 82  ASP 82  82  82  ASP ASP L . n 
C 3 83  PHE 83  83  83  PHE PHE L . n 
C 3 84  ALA 84  84  84  ALA ALA L . n 
C 3 85  THR 85  85  85  THR THR L . n 
C 3 86  TYR 86  86  86  TYR TYR L . n 
C 3 87  TYR 87  87  87  TYR TYR L . n 
C 3 88  CYS 88  88  88  CYS CYS L . n 
C 3 89  GLN 89  89  89  GLN GLN L . n 
C 3 90  GLN 90  90  90  GLN GLN L . n 
C 3 91  SER 91  91  91  SER SER L . n 
C 3 92  TYR 92  92  92  TYR TYR L . n 
C 3 93  ASN 93  93  93  ASN ASN L . n 
C 3 94  THR 94  94  94  THR THR L . n 
C 3 95  PRO 95  95  95  PRO PRO L . n 
C 3 96  PRO 96  96  96  PRO PRO L . n 
C 3 97  THR 97  97  97  THR THR L . n 
C 3 98  PHE 98  98  98  PHE PHE L . n 
C 3 99  GLY 99  99  99  GLY GLY L . n 
C 3 100 GLN 100 100 100 GLN GLN L . n 
C 3 101 GLY 101 101 101 GLY GLY L . n 
C 3 102 THR 102 102 102 THR THR L . n 
C 3 103 LYS 103 103 103 LYS LYS L . n 
C 3 104 VAL 104 104 104 VAL VAL L . n 
C 3 105 GLU 105 105 105 GLU GLU L . n 
C 3 106 ILE 106 106 106 ILE ILE L . n 
C 3 107 LYS 107 107 107 LYS LYS L . n 
C 3 108 ARG 108 108 108 ARG ARG L . n 
C 3 109 THR 109 109 109 THR THR L . n 
C 3 110 VAL 110 110 110 VAL VAL L . n 
C 3 111 ALA 111 111 111 ALA ALA L . n 
C 3 112 ALA 112 112 112 ALA ALA L . n 
C 3 113 PRO 113 113 113 PRO PRO L . n 
C 3 114 SER 114 114 114 SER SER L . n 
C 3 115 VAL 115 115 115 VAL VAL L . n 
C 3 116 PHE 116 116 116 PHE PHE L . n 
C 3 117 ILE 117 117 117 ILE ILE L . n 
C 3 118 PHE 118 118 118 PHE PHE L . n 
C 3 119 PRO 119 119 119 PRO PRO L . n 
C 3 120 PRO 120 120 120 PRO PRO L . n 
C 3 121 SER 121 121 121 SER SER L . n 
C 3 122 ASP 122 122 122 ASP ASP L . n 
C 3 123 GLU 123 123 123 GLU GLU L . n 
C 3 124 GLN 124 124 124 GLN GLN L . n 
C 3 125 LEU 125 125 125 LEU LEU L . n 
C 3 126 LYS 126 126 126 LYS LYS L . n 
C 3 127 SER 127 127 127 SER SER L . n 
C 3 128 GLY 128 128 128 GLY GLY L . n 
C 3 129 THR 129 129 129 THR THR L . n 
C 3 130 ALA 130 130 130 ALA ALA L . n 
C 3 131 SER 131 131 131 SER SER L . n 
C 3 132 VAL 132 132 132 VAL VAL L . n 
C 3 133 VAL 133 133 133 VAL VAL L . n 
C 3 134 CYS 134 134 134 CYS CYS L . n 
C 3 135 LEU 135 135 135 LEU LEU L . n 
C 3 136 LEU 136 136 136 LEU LEU L . n 
C 3 137 ASN 137 137 137 ASN ASN L . n 
C 3 138 ASN 138 138 138 ASN ASN L . n 
C 3 139 PHE 139 139 139 PHE PHE L . n 
C 3 140 TYR 140 140 140 TYR TYR L . n 
C 3 141 PRO 141 141 141 PRO PRO L . n 
C 3 142 ARG 142 142 142 ARG ARG L . n 
C 3 143 GLU 143 143 143 GLU GLU L . n 
C 3 144 ALA 144 144 144 ALA ALA L . n 
C 3 145 LYS 145 145 145 LYS LYS L . n 
C 3 146 VAL 146 146 146 VAL VAL L . n 
C 3 147 GLN 147 147 147 GLN GLN L . n 
C 3 148 TRP 148 148 148 TRP TRP L . n 
C 3 149 LYS 149 149 149 LYS LYS L . n 
C 3 150 VAL 150 150 150 VAL VAL L . n 
C 3 151 ASP 151 151 151 ASP ASP L . n 
C 3 152 ASN 152 152 152 ASN ASN L . n 
C 3 153 ALA 153 153 153 ALA ALA L . n 
C 3 154 LEU 154 154 154 LEU LEU L . n 
C 3 155 GLN 155 155 155 GLN GLN L . n 
C 3 156 SER 156 156 156 SER SER L . n 
C 3 157 GLY 157 157 157 GLY GLY L . n 
C 3 158 ASN 158 158 158 ASN ASN L . n 
C 3 159 SER 159 159 159 SER SER L . n 
C 3 160 GLN 160 160 160 GLN GLN L . n 
C 3 161 GLU 161 161 161 GLU GLU L . n 
C 3 162 SER 162 162 162 SER SER L . n 
C 3 163 VAL 163 163 163 VAL VAL L . n 
C 3 164 THR 164 164 164 THR THR L . n 
C 3 165 GLU 165 165 165 GLU GLU L . n 
C 3 166 GLN 166 166 166 GLN GLN L . n 
C 3 167 ASP 167 167 167 ASP ASP L . n 
C 3 168 SER 168 168 168 SER SER L . n 
C 3 169 LYS 169 169 169 LYS LYS L . n 
C 3 170 ASP 170 170 170 ASP ASP L . n 
C 3 171 SER 171 171 171 SER SER L . n 
C 3 172 THR 172 172 172 THR THR L . n 
C 3 173 TYR 173 173 173 TYR TYR L . n 
C 3 174 SER 174 174 174 SER SER L . n 
C 3 175 LEU 175 175 175 LEU LEU L . n 
C 3 176 SER 176 176 176 SER SER L . n 
C 3 177 SER 177 177 177 SER SER L . n 
C 3 178 THR 178 178 178 THR THR L . n 
C 3 179 LEU 179 179 179 LEU LEU L . n 
C 3 180 THR 180 180 180 THR THR L . n 
C 3 181 LEU 181 181 181 LEU LEU L . n 
C 3 182 SER 182 182 182 SER SER L . n 
C 3 183 LYS 183 183 183 LYS LYS L . n 
C 3 184 ALA 184 184 184 ALA ALA L . n 
C 3 185 ASP 185 185 185 ASP ASP L . n 
C 3 186 TYR 186 186 186 TYR TYR L . n 
C 3 187 GLU 187 187 187 GLU GLU L . n 
C 3 188 LYS 188 188 188 LYS LYS L . n 
C 3 189 HIS 189 189 189 HIS HIS L . n 
C 3 190 LYS 190 190 190 LYS LYS L . n 
C 3 191 VAL 191 191 191 VAL VAL L . n 
C 3 192 TYR 192 192 192 TYR TYR L . n 
C 3 193 ALA 193 193 193 ALA ALA L . n 
C 3 194 CYS 194 194 194 CYS CYS L . n 
C 3 195 GLU 195 195 195 GLU GLU L . n 
C 3 196 VAL 196 196 196 VAL VAL L . n 
C 3 197 THR 197 197 197 THR THR L . n 
C 3 198 HIS 198 198 198 HIS HIS L . n 
C 3 199 GLN 199 199 199 GLN GLN L . n 
C 3 200 GLY 200 200 200 GLY GLY L . n 
C 3 201 LEU 201 201 201 LEU LEU L . n 
C 3 202 SER 202 202 202 SER SER L . n 
C 3 203 SER 203 203 203 SER SER L . n 
C 3 204 PRO 204 204 204 PRO PRO L . n 
C 3 205 VAL 205 205 205 VAL VAL L . n 
C 3 206 THR 206 206 206 THR THR L . n 
C 3 207 LYS 207 207 207 LYS LYS L . n 
C 3 208 SER 208 208 208 SER SER L . n 
C 3 209 PHE 209 209 209 PHE PHE L . n 
C 3 210 ASN 210 210 210 ASN ASN L . n 
C 3 211 ARG 211 211 211 ARG ARG L . n 
C 3 212 GLY 212 212 212 GLY GLY L . n 
C 3 213 GLU 213 213 213 GLU GLU L . n 
C 3 214 CYS 214 214 ?   ?   ?   L . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
D 4 NAG 1 A NAG 1 B NAG 266 n 
D 4 NAG 2 A NAG 2 B NAG 267 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 5 NAG 1   301 268 NAG NAG B . 
F 6 EDO 1   301 302 EDO EDO H . 
G 6 EDO 1   301 301 EDO EDO L . 
H 6 EDO 1   302 303 EDO EDO L . 
I 6 EDO 1   303 304 EDO EDO L . 
J 6 EDO 1   304 305 EDO EDO L . 
K 6 EDO 1   305 306 EDO EDO L . 
L 7 HOH 1   401 316 HOH HOH B . 
L 7 HOH 2   402 594 HOH HOH B . 
L 7 HOH 3   403 534 HOH HOH B . 
L 7 HOH 4   404 240 HOH HOH B . 
L 7 HOH 5   405 15  HOH HOH B . 
L 7 HOH 6   406 447 HOH HOH B . 
L 7 HOH 7   407 71  HOH HOH B . 
L 7 HOH 8   408 92  HOH HOH B . 
L 7 HOH 9   409 568 HOH HOH B . 
L 7 HOH 10  410 537 HOH HOH B . 
L 7 HOH 11  411 573 HOH HOH B . 
L 7 HOH 12  412 30  HOH HOH B . 
L 7 HOH 13  413 555 HOH HOH B . 
L 7 HOH 14  414 183 HOH HOH B . 
L 7 HOH 15  415 223 HOH HOH B . 
L 7 HOH 16  416 251 HOH HOH B . 
L 7 HOH 17  417 55  HOH HOH B . 
L 7 HOH 18  418 390 HOH HOH B . 
L 7 HOH 19  419 8   HOH HOH B . 
L 7 HOH 20  420 297 HOH HOH B . 
L 7 HOH 21  421 308 HOH HOH B . 
L 7 HOH 22  422 104 HOH HOH B . 
L 7 HOH 23  423 160 HOH HOH B . 
L 7 HOH 24  424 272 HOH HOH B . 
L 7 HOH 25  425 336 HOH HOH B . 
L 7 HOH 26  426 180 HOH HOH B . 
L 7 HOH 27  427 191 HOH HOH B . 
L 7 HOH 28  428 451 HOH HOH B . 
L 7 HOH 29  429 36  HOH HOH B . 
L 7 HOH 30  430 305 HOH HOH B . 
L 7 HOH 31  431 47  HOH HOH B . 
L 7 HOH 32  432 76  HOH HOH B . 
L 7 HOH 33  433 131 HOH HOH B . 
L 7 HOH 34  434 545 HOH HOH B . 
L 7 HOH 35  435 119 HOH HOH B . 
L 7 HOH 36  436 111 HOH HOH B . 
L 7 HOH 37  437 225 HOH HOH B . 
L 7 HOH 38  438 255 HOH HOH B . 
L 7 HOH 39  439 405 HOH HOH B . 
L 7 HOH 40  440 338 HOH HOH B . 
L 7 HOH 41  441 102 HOH HOH B . 
L 7 HOH 42  442 442 HOH HOH B . 
L 7 HOH 43  443 261 HOH HOH B . 
L 7 HOH 44  444 48  HOH HOH B . 
L 7 HOH 45  445 52  HOH HOH B . 
L 7 HOH 46  446 588 HOH HOH B . 
L 7 HOH 47  447 236 HOH HOH B . 
L 7 HOH 48  448 195 HOH HOH B . 
L 7 HOH 49  449 128 HOH HOH B . 
L 7 HOH 50  450 263 HOH HOH B . 
L 7 HOH 51  451 62  HOH HOH B . 
L 7 HOH 52  452 100 HOH HOH B . 
L 7 HOH 53  453 95  HOH HOH B . 
L 7 HOH 54  454 464 HOH HOH B . 
L 7 HOH 55  455 125 HOH HOH B . 
L 7 HOH 56  456 155 HOH HOH B . 
L 7 HOH 57  457 421 HOH HOH B . 
L 7 HOH 58  458 59  HOH HOH B . 
L 7 HOH 59  459 217 HOH HOH B . 
L 7 HOH 60  460 274 HOH HOH B . 
L 7 HOH 61  461 32  HOH HOH B . 
L 7 HOH 62  462 154 HOH HOH B . 
L 7 HOH 63  463 341 HOH HOH B . 
L 7 HOH 64  464 110 HOH HOH B . 
L 7 HOH 65  465 385 HOH HOH B . 
L 7 HOH 66  466 309 HOH HOH B . 
L 7 HOH 67  467 547 HOH HOH B . 
L 7 HOH 68  468 175 HOH HOH B . 
L 7 HOH 69  469 239 HOH HOH B . 
L 7 HOH 70  470 363 HOH HOH B . 
L 7 HOH 71  471 186 HOH HOH B . 
L 7 HOH 72  472 114 HOH HOH B . 
L 7 HOH 73  473 67  HOH HOH B . 
L 7 HOH 74  474 234 HOH HOH B . 
L 7 HOH 75  475 538 HOH HOH B . 
L 7 HOH 76  476 368 HOH HOH B . 
L 7 HOH 77  477 477 HOH HOH B . 
L 7 HOH 78  478 285 HOH HOH B . 
L 7 HOH 79  479 387 HOH HOH B . 
L 7 HOH 80  480 290 HOH HOH B . 
L 7 HOH 81  481 345 HOH HOH B . 
L 7 HOH 82  482 623 HOH HOH B . 
L 7 HOH 83  483 24  HOH HOH B . 
L 7 HOH 84  484 299 HOH HOH B . 
L 7 HOH 85  485 391 HOH HOH B . 
L 7 HOH 86  486 296 HOH HOH B . 
L 7 HOH 87  487 215 HOH HOH B . 
L 7 HOH 88  488 150 HOH HOH B . 
L 7 HOH 89  489 135 HOH HOH B . 
L 7 HOH 90  490 271 HOH HOH B . 
L 7 HOH 91  491 153 HOH HOH B . 
L 7 HOH 92  492 245 HOH HOH B . 
L 7 HOH 93  493 262 HOH HOH B . 
L 7 HOH 94  494 169 HOH HOH B . 
L 7 HOH 95  495 446 HOH HOH B . 
L 7 HOH 96  496 137 HOH HOH B . 
L 7 HOH 97  497 380 HOH HOH B . 
L 7 HOH 98  498 360 HOH HOH B . 
L 7 HOH 99  499 342 HOH HOH B . 
L 7 HOH 100 500 513 HOH HOH B . 
L 7 HOH 101 501 163 HOH HOH B . 
L 7 HOH 102 502 218 HOH HOH B . 
L 7 HOH 103 503 166 HOH HOH B . 
L 7 HOH 104 504 406 HOH HOH B . 
L 7 HOH 105 505 530 HOH HOH B . 
L 7 HOH 106 506 596 HOH HOH B . 
L 7 HOH 107 507 129 HOH HOH B . 
L 7 HOH 108 508 439 HOH HOH B . 
L 7 HOH 109 509 383 HOH HOH B . 
L 7 HOH 110 510 12  HOH HOH B . 
L 7 HOH 111 511 346 HOH HOH B . 
L 7 HOH 112 512 578 HOH HOH B . 
L 7 HOH 113 513 543 HOH HOH B . 
L 7 HOH 114 514 204 HOH HOH B . 
L 7 HOH 115 515 335 HOH HOH B . 
L 7 HOH 116 516 347 HOH HOH B . 
L 7 HOH 117 517 267 HOH HOH B . 
L 7 HOH 118 518 408 HOH HOH B . 
L 7 HOH 119 519 526 HOH HOH B . 
L 7 HOH 120 520 214 HOH HOH B . 
L 7 HOH 121 521 382 HOH HOH B . 
L 7 HOH 122 522 196 HOH HOH B . 
L 7 HOH 123 523 607 HOH HOH B . 
L 7 HOH 124 524 531 HOH HOH B . 
L 7 HOH 125 525 147 HOH HOH B . 
L 7 HOH 126 526 546 HOH HOH B . 
L 7 HOH 127 527 366 HOH HOH B . 
L 7 HOH 128 528 417 HOH HOH B . 
L 7 HOH 129 529 374 HOH HOH B . 
L 7 HOH 130 530 414 HOH HOH B . 
L 7 HOH 131 531 525 HOH HOH B . 
L 7 HOH 132 532 474 HOH HOH B . 
L 7 HOH 133 533 398 HOH HOH B . 
L 7 HOH 134 534 587 HOH HOH B . 
L 7 HOH 135 535 535 HOH HOH B . 
L 7 HOH 136 536 502 HOH HOH B . 
L 7 HOH 137 537 378 HOH HOH B . 
L 7 HOH 138 538 457 HOH HOH B . 
L 7 HOH 139 539 355 HOH HOH B . 
L 7 HOH 140 540 356 HOH HOH B . 
L 7 HOH 141 541 422 HOH HOH B . 
L 7 HOH 142 542 247 HOH HOH B . 
L 7 HOH 143 543 614 HOH HOH B . 
L 7 HOH 144 544 569 HOH HOH B . 
L 7 HOH 145 545 88  HOH HOH B . 
L 7 HOH 146 546 187 HOH HOH B . 
L 7 HOH 147 547 367 HOH HOH B . 
L 7 HOH 148 548 581 HOH HOH B . 
L 7 HOH 149 549 452 HOH HOH B . 
L 7 HOH 150 550 517 HOH HOH B . 
L 7 HOH 151 551 449 HOH HOH B . 
L 7 HOH 152 552 207 HOH HOH B . 
L 7 HOH 153 553 605 HOH HOH B . 
L 7 HOH 154 554 600 HOH HOH B . 
L 7 HOH 155 555 407 HOH HOH B . 
L 7 HOH 156 556 362 HOH HOH B . 
L 7 HOH 157 557 337 HOH HOH B . 
L 7 HOH 158 558 522 HOH HOH B . 
L 7 HOH 159 559 438 HOH HOH B . 
L 7 HOH 160 560 425 HOH HOH B . 
L 7 HOH 161 561 455 HOH HOH B . 
L 7 HOH 162 562 478 HOH HOH B . 
L 7 HOH 163 563 483 HOH HOH B . 
L 7 HOH 164 564 492 HOH HOH B . 
L 7 HOH 165 565 591 HOH HOH B . 
M 7 HOH 1   401 575 HOH HOH H . 
M 7 HOH 2   402 97  HOH HOH H . 
M 7 HOH 3   403 529 HOH HOH H . 
M 7 HOH 4   404 233 HOH HOH H . 
M 7 HOH 5   405 136 HOH HOH H . 
M 7 HOH 6   406 203 HOH HOH H . 
M 7 HOH 7   407 181 HOH HOH H . 
M 7 HOH 8   408 559 HOH HOH H . 
M 7 HOH 9   409 287 HOH HOH H . 
M 7 HOH 10  410 476 HOH HOH H . 
M 7 HOH 11  411 198 HOH HOH H . 
M 7 HOH 12  412 87  HOH HOH H . 
M 7 HOH 13  413 56  HOH HOH H . 
M 7 HOH 14  414 86  HOH HOH H . 
M 7 HOH 15  415 306 HOH HOH H . 
M 7 HOH 16  416 64  HOH HOH H . 
M 7 HOH 17  417 3   HOH HOH H . 
M 7 HOH 18  418 40  HOH HOH H . 
M 7 HOH 19  419 393 HOH HOH H . 
M 7 HOH 20  420 10  HOH HOH H . 
M 7 HOH 21  421 595 HOH HOH H . 
M 7 HOH 22  422 33  HOH HOH H . 
M 7 HOH 23  423 43  HOH HOH H . 
M 7 HOH 24  424 9   HOH HOH H . 
M 7 HOH 25  425 213 HOH HOH H . 
M 7 HOH 26  426 51  HOH HOH H . 
M 7 HOH 27  427 2   HOH HOH H . 
M 7 HOH 28  428 107 HOH HOH H . 
M 7 HOH 29  429 14  HOH HOH H . 
M 7 HOH 30  430 17  HOH HOH H . 
M 7 HOH 31  431 23  HOH HOH H . 
M 7 HOH 32  432 501 HOH HOH H . 
M 7 HOH 33  433 590 HOH HOH H . 
M 7 HOH 34  434 165 HOH HOH H . 
M 7 HOH 35  435 257 HOH HOH H . 
M 7 HOH 36  436 74  HOH HOH H . 
M 7 HOH 37  437 172 HOH HOH H . 
M 7 HOH 38  438 189 HOH HOH H . 
M 7 HOH 39  439 219 HOH HOH H . 
M 7 HOH 40  440 28  HOH HOH H . 
M 7 HOH 41  441 99  HOH HOH H . 
M 7 HOH 42  442 243 HOH HOH H . 
M 7 HOH 43  443 126 HOH HOH H . 
M 7 HOH 44  444 151 HOH HOH H . 
M 7 HOH 45  445 121 HOH HOH H . 
M 7 HOH 46  446 117 HOH HOH H . 
M 7 HOH 47  447 190 HOH HOH H . 
M 7 HOH 48  448 57  HOH HOH H . 
M 7 HOH 49  449 256 HOH HOH H . 
M 7 HOH 50  450 205 HOH HOH H . 
M 7 HOH 51  451 470 HOH HOH H . 
M 7 HOH 52  452 428 HOH HOH H . 
M 7 HOH 53  453 115 HOH HOH H . 
M 7 HOH 54  454 60  HOH HOH H . 
M 7 HOH 55  455 63  HOH HOH H . 
M 7 HOH 56  456 85  HOH HOH H . 
M 7 HOH 57  457 174 HOH HOH H . 
M 7 HOH 58  458 202 HOH HOH H . 
M 7 HOH 59  459 78  HOH HOH H . 
M 7 HOH 60  460 403 HOH HOH H . 
M 7 HOH 61  461 461 HOH HOH H . 
M 7 HOH 62  462 343 HOH HOH H . 
M 7 HOH 63  463 133 HOH HOH H . 
M 7 HOH 64  464 231 HOH HOH H . 
M 7 HOH 65  465 436 HOH HOH H . 
M 7 HOH 66  466 312 HOH HOH H . 
M 7 HOH 67  467 334 HOH HOH H . 
M 7 HOH 68  468 39  HOH HOH H . 
M 7 HOH 69  469 69  HOH HOH H . 
M 7 HOH 70  470 179 HOH HOH H . 
M 7 HOH 71  471 298 HOH HOH H . 
M 7 HOH 72  472 34  HOH HOH H . 
M 7 HOH 73  473 277 HOH HOH H . 
M 7 HOH 74  474 93  HOH HOH H . 
M 7 HOH 75  475 254 HOH HOH H . 
M 7 HOH 76  476 232 HOH HOH H . 
M 7 HOH 77  477 70  HOH HOH H . 
M 7 HOH 78  478 400 HOH HOH H . 
M 7 HOH 79  479 158 HOH HOH H . 
M 7 HOH 80  480 164 HOH HOH H . 
M 7 HOH 81  481 94  HOH HOH H . 
M 7 HOH 82  482 91  HOH HOH H . 
M 7 HOH 83  483 199 HOH HOH H . 
M 7 HOH 84  484 248 HOH HOH H . 
M 7 HOH 85  485 35  HOH HOH H . 
M 7 HOH 86  486 258 HOH HOH H . 
M 7 HOH 87  487 122 HOH HOH H . 
M 7 HOH 88  488 4   HOH HOH H . 
M 7 HOH 89  489 303 HOH HOH H . 
M 7 HOH 90  490 145 HOH HOH H . 
M 7 HOH 91  491 118 HOH HOH H . 
M 7 HOH 92  492 562 HOH HOH H . 
M 7 HOH 93  493 320 HOH HOH H . 
M 7 HOH 94  494 353 HOH HOH H . 
M 7 HOH 95  495 282 HOH HOH H . 
M 7 HOH 96  496 572 HOH HOH H . 
M 7 HOH 97  497 45  HOH HOH H . 
M 7 HOH 98  498 401 HOH HOH H . 
M 7 HOH 99  499 156 HOH HOH H . 
M 7 HOH 100 500 580 HOH HOH H . 
M 7 HOH 101 501 81  HOH HOH H . 
M 7 HOH 102 502 68  HOH HOH H . 
M 7 HOH 103 503 211 HOH HOH H . 
M 7 HOH 104 504 173 HOH HOH H . 
M 7 HOH 105 505 73  HOH HOH H . 
M 7 HOH 106 506 518 HOH HOH H . 
M 7 HOH 107 507 494 HOH HOH H . 
M 7 HOH 108 508 27  HOH HOH H . 
M 7 HOH 109 509 311 HOH HOH H . 
M 7 HOH 110 510 230 HOH HOH H . 
M 7 HOH 111 511 288 HOH HOH H . 
M 7 HOH 112 512 295 HOH HOH H . 
M 7 HOH 113 513 238 HOH HOH H . 
M 7 HOH 114 514 170 HOH HOH H . 
M 7 HOH 115 515 124 HOH HOH H . 
M 7 HOH 116 516 75  HOH HOH H . 
M 7 HOH 117 517 389 HOH HOH H . 
M 7 HOH 118 518 521 HOH HOH H . 
M 7 HOH 119 519 279 HOH HOH H . 
M 7 HOH 120 520 570 HOH HOH H . 
M 7 HOH 121 521 42  HOH HOH H . 
M 7 HOH 122 522 265 HOH HOH H . 
M 7 HOH 123 523 397 HOH HOH H . 
M 7 HOH 124 524 301 HOH HOH H . 
M 7 HOH 125 525 21  HOH HOH H . 
M 7 HOH 126 526 98  HOH HOH H . 
M 7 HOH 127 527 142 HOH HOH H . 
M 7 HOH 128 528 348 HOH HOH H . 
M 7 HOH 129 529 350 HOH HOH H . 
M 7 HOH 130 530 566 HOH HOH H . 
M 7 HOH 131 531 450 HOH HOH H . 
M 7 HOH 132 532 504 HOH HOH H . 
M 7 HOH 133 533 394 HOH HOH H . 
M 7 HOH 134 534 304 HOH HOH H . 
M 7 HOH 135 535 617 HOH HOH H . 
M 7 HOH 136 536 441 HOH HOH H . 
M 7 HOH 137 537 325 HOH HOH H . 
M 7 HOH 138 538 371 HOH HOH H . 
M 7 HOH 139 539 567 HOH HOH H . 
M 7 HOH 140 540 402 HOH HOH H . 
M 7 HOH 141 541 112 HOH HOH H . 
M 7 HOH 142 542 495 HOH HOH H . 
M 7 HOH 143 543 319 HOH HOH H . 
M 7 HOH 144 544 416 HOH HOH H . 
M 7 HOH 145 545 472 HOH HOH H . 
M 7 HOH 146 546 613 HOH HOH H . 
M 7 HOH 147 547 323 HOH HOH H . 
M 7 HOH 148 548 444 HOH HOH H . 
M 7 HOH 149 549 463 HOH HOH H . 
M 7 HOH 150 550 508 HOH HOH H . 
M 7 HOH 151 551 621 HOH HOH H . 
M 7 HOH 152 552 527 HOH HOH H . 
M 7 HOH 153 553 532 HOH HOH H . 
M 7 HOH 154 554 589 HOH HOH H . 
M 7 HOH 155 555 412 HOH HOH H . 
M 7 HOH 156 556 31  HOH HOH H . 
M 7 HOH 157 557 564 HOH HOH H . 
M 7 HOH 158 558 182 HOH HOH H . 
M 7 HOH 159 559 235 HOH HOH H . 
M 7 HOH 160 560 185 HOH HOH H . 
M 7 HOH 161 561 331 HOH HOH H . 
M 7 HOH 162 562 388 HOH HOH H . 
M 7 HOH 163 563 377 HOH HOH H . 
M 7 HOH 164 564 618 HOH HOH H . 
M 7 HOH 165 565 200 HOH HOH H . 
M 7 HOH 166 566 443 HOH HOH H . 
M 7 HOH 167 567 161 HOH HOH H . 
M 7 HOH 168 568 608 HOH HOH H . 
M 7 HOH 169 569 351 HOH HOH H . 
M 7 HOH 170 570 410 HOH HOH H . 
M 7 HOH 171 571 310 HOH HOH H . 
M 7 HOH 172 572 324 HOH HOH H . 
M 7 HOH 173 573 270 HOH HOH H . 
M 7 HOH 174 574 473 HOH HOH H . 
M 7 HOH 175 575 448 HOH HOH H . 
M 7 HOH 176 576 386 HOH HOH H . 
M 7 HOH 177 577 344 HOH HOH H . 
M 7 HOH 178 578 286 HOH HOH H . 
M 7 HOH 179 579 435 HOH HOH H . 
M 7 HOH 180 580 313 HOH HOH H . 
M 7 HOH 181 581 171 HOH HOH H . 
M 7 HOH 182 582 475 HOH HOH H . 
M 7 HOH 183 583 445 HOH HOH H . 
M 7 HOH 184 584 266 HOH HOH H . 
M 7 HOH 185 585 420 HOH HOH H . 
M 7 HOH 186 586 381 HOH HOH H . 
M 7 HOH 187 587 466 HOH HOH H . 
M 7 HOH 188 588 423 HOH HOH H . 
M 7 HOH 189 589 132 HOH HOH H . 
M 7 HOH 190 590 512 HOH HOH H . 
M 7 HOH 191 591 370 HOH HOH H . 
M 7 HOH 192 592 533 HOH HOH H . 
M 7 HOH 193 593 574 HOH HOH H . 
M 7 HOH 194 594 507 HOH HOH H . 
M 7 HOH 195 595 152 HOH HOH H . 
M 7 HOH 196 596 284 HOH HOH H . 
M 7 HOH 197 597 509 HOH HOH H . 
M 7 HOH 198 598 192 HOH HOH H . 
M 7 HOH 199 599 314 HOH HOH H . 
M 7 HOH 200 600 332 HOH HOH H . 
M 7 HOH 201 601 471 HOH HOH H . 
M 7 HOH 202 602 479 HOH HOH H . 
M 7 HOH 203 603 490 HOH HOH H . 
M 7 HOH 204 604 592 HOH HOH H . 
M 7 HOH 205 605 554 HOH HOH H . 
M 7 HOH 206 606 539 HOH HOH H . 
M 7 HOH 207 607 510 HOH HOH H . 
M 7 HOH 208 608 488 HOH HOH H . 
M 7 HOH 209 609 458 HOH HOH H . 
M 7 HOH 210 610 577 HOH HOH H . 
M 7 HOH 211 611 616 HOH HOH H . 
M 7 HOH 212 612 611 HOH HOH H . 
M 7 HOH 213 613 612 HOH HOH H . 
N 7 HOH 1   401 105 HOH HOH L . 
N 7 HOH 2   402 260 HOH HOH L . 
N 7 HOH 3   403 194 HOH HOH L . 
N 7 HOH 4   404 560 HOH HOH L . 
N 7 HOH 5   405 188 HOH HOH L . 
N 7 HOH 6   406 259 HOH HOH L . 
N 7 HOH 7   407 77  HOH HOH L . 
N 7 HOH 8   408 620 HOH HOH L . 
N 7 HOH 9   409 82  HOH HOH L . 
N 7 HOH 10  410 127 HOH HOH L . 
N 7 HOH 11  411 113 HOH HOH L . 
N 7 HOH 12  412 49  HOH HOH L . 
N 7 HOH 13  413 66  HOH HOH L . 
N 7 HOH 14  414 249 HOH HOH L . 
N 7 HOH 15  415 520 HOH HOH L . 
N 7 HOH 16  416 38  HOH HOH L . 
N 7 HOH 17  417 606 HOH HOH L . 
N 7 HOH 18  418 210 HOH HOH L . 
N 7 HOH 19  419 44  HOH HOH L . 
N 7 HOH 20  420 275 HOH HOH L . 
N 7 HOH 21  421 333 HOH HOH L . 
N 7 HOH 22  422 201 HOH HOH L . 
N 7 HOH 23  423 237 HOH HOH L . 
N 7 HOH 24  424 7   HOH HOH L . 
N 7 HOH 25  425 330 HOH HOH L . 
N 7 HOH 26  426 138 HOH HOH L . 
N 7 HOH 27  427 120 HOH HOH L . 
N 7 HOH 28  428 65  HOH HOH L . 
N 7 HOH 29  429 162 HOH HOH L . 
N 7 HOH 30  430 26  HOH HOH L . 
N 7 HOH 31  431 130 HOH HOH L . 
N 7 HOH 32  432 108 HOH HOH L . 
N 7 HOH 33  433 523 HOH HOH L . 
N 7 HOH 34  434 37  HOH HOH L . 
N 7 HOH 35  435 72  HOH HOH L . 
N 7 HOH 36  436 329 HOH HOH L . 
N 7 HOH 37  437 159 HOH HOH L . 
N 7 HOH 38  438 58  HOH HOH L . 
N 7 HOH 39  439 571 HOH HOH L . 
N 7 HOH 40  440 101 HOH HOH L . 
N 7 HOH 41  441 13  HOH HOH L . 
N 7 HOH 42  442 46  HOH HOH L . 
N 7 HOH 43  443 597 HOH HOH L . 
N 7 HOH 44  444 228 HOH HOH L . 
N 7 HOH 45  445 25  HOH HOH L . 
N 7 HOH 46  446 79  HOH HOH L . 
N 7 HOH 47  447 176 HOH HOH L . 
N 7 HOH 48  448 229 HOH HOH L . 
N 7 HOH 49  449 16  HOH HOH L . 
N 7 HOH 50  450 193 HOH HOH L . 
N 7 HOH 51  451 399 HOH HOH L . 
N 7 HOH 52  452 273 HOH HOH L . 
N 7 HOH 53  453 481 HOH HOH L . 
N 7 HOH 54  454 468 HOH HOH L . 
N 7 HOH 55  455 11  HOH HOH L . 
N 7 HOH 56  456 593 HOH HOH L . 
N 7 HOH 57  457 269 HOH HOH L . 
N 7 HOH 58  458 54  HOH HOH L . 
N 7 HOH 59  459 134 HOH HOH L . 
N 7 HOH 60  460 453 HOH HOH L . 
N 7 HOH 61  461 349 HOH HOH L . 
N 7 HOH 62  462 419 HOH HOH L . 
N 7 HOH 63  463 576 HOH HOH L . 
N 7 HOH 64  464 434 HOH HOH L . 
N 7 HOH 65  465 50  HOH HOH L . 
N 7 HOH 66  466 283 HOH HOH L . 
N 7 HOH 67  467 146 HOH HOH L . 
N 7 HOH 68  468 41  HOH HOH L . 
N 7 HOH 69  469 6   HOH HOH L . 
N 7 HOH 70  470 497 HOH HOH L . 
N 7 HOH 71  471 227 HOH HOH L . 
N 7 HOH 72  472 352 HOH HOH L . 
N 7 HOH 73  473 604 HOH HOH L . 
N 7 HOH 74  474 315 HOH HOH L . 
N 7 HOH 75  475 89  HOH HOH L . 
N 7 HOH 76  476 83  HOH HOH L . 
N 7 HOH 77  477 84  HOH HOH L . 
N 7 HOH 78  478 123 HOH HOH L . 
N 7 HOH 79  479 328 HOH HOH L . 
N 7 HOH 80  480 373 HOH HOH L . 
N 7 HOH 81  481 61  HOH HOH L . 
N 7 HOH 82  482 216 HOH HOH L . 
N 7 HOH 83  483 264 HOH HOH L . 
N 7 HOH 84  484 53  HOH HOH L . 
N 7 HOH 85  485 206 HOH HOH L . 
N 7 HOH 86  486 252 HOH HOH L . 
N 7 HOH 87  487 167 HOH HOH L . 
N 7 HOH 88  488 357 HOH HOH L . 
N 7 HOH 89  489 482 HOH HOH L . 
N 7 HOH 90  490 376 HOH HOH L . 
N 7 HOH 91  491 139 HOH HOH L . 
N 7 HOH 92  492 278 HOH HOH L . 
N 7 HOH 93  493 375 HOH HOH L . 
N 7 HOH 94  494 148 HOH HOH L . 
N 7 HOH 95  495 253 HOH HOH L . 
N 7 HOH 96  496 208 HOH HOH L . 
N 7 HOH 97  497 396 HOH HOH L . 
N 7 HOH 98  498 395 HOH HOH L . 
N 7 HOH 99  499 599 HOH HOH L . 
N 7 HOH 100 500 339 HOH HOH L . 
N 7 HOH 101 501 222 HOH HOH L . 
N 7 HOH 102 502 506 HOH HOH L . 
N 7 HOH 103 503 242 HOH HOH L . 
N 7 HOH 104 504 558 HOH HOH L . 
N 7 HOH 105 505 432 HOH HOH L . 
N 7 HOH 106 506 467 HOH HOH L . 
N 7 HOH 107 507 359 HOH HOH L . 
N 7 HOH 108 508 456 HOH HOH L . 
N 7 HOH 109 509 209 HOH HOH L . 
N 7 HOH 110 510 415 HOH HOH L . 
N 7 HOH 111 511 511 HOH HOH L . 
N 7 HOH 112 512 220 HOH HOH L . 
N 7 HOH 113 513 18  HOH HOH L . 
N 7 HOH 114 514 317 HOH HOH L . 
N 7 HOH 115 515 514 HOH HOH L . 
N 7 HOH 116 516 603 HOH HOH L . 
N 7 HOH 117 517 244 HOH HOH L . 
N 7 HOH 118 518 141 HOH HOH L . 
N 7 HOH 119 519 149 HOH HOH L . 
N 7 HOH 120 520 22  HOH HOH L . 
N 7 HOH 121 521 392 HOH HOH L . 
N 7 HOH 122 522 460 HOH HOH L . 
N 7 HOH 123 523 469 HOH HOH L . 
N 7 HOH 124 524 294 HOH HOH L . 
N 7 HOH 125 525 365 HOH HOH L . 
N 7 HOH 126 526 178 HOH HOH L . 
N 7 HOH 127 527 489 HOH HOH L . 
N 7 HOH 128 528 90  HOH HOH L . 
N 7 HOH 129 529 541 HOH HOH L . 
N 7 HOH 130 530 565 HOH HOH L . 
N 7 HOH 131 531 563 HOH HOH L . 
N 7 HOH 132 532 433 HOH HOH L . 
N 7 HOH 133 533 340 HOH HOH L . 
N 7 HOH 134 534 140 HOH HOH L . 
N 7 HOH 135 535 241 HOH HOH L . 
N 7 HOH 136 536 327 HOH HOH L . 
N 7 HOH 137 537 609 HOH HOH L . 
N 7 HOH 138 538 503 HOH HOH L . 
N 7 HOH 139 539 157 HOH HOH L . 
N 7 HOH 140 540 221 HOH HOH L . 
N 7 HOH 141 541 429 HOH HOH L . 
N 7 HOH 142 542 307 HOH HOH L . 
N 7 HOH 143 543 496 HOH HOH L . 
N 7 HOH 144 544 579 HOH HOH L . 
N 7 HOH 145 545 411 HOH HOH L . 
N 7 HOH 146 546 379 HOH HOH L . 
N 7 HOH 147 547 354 HOH HOH L . 
N 7 HOH 148 548 103 HOH HOH L . 
N 7 HOH 149 549 499 HOH HOH L . 
N 7 HOH 150 550 431 HOH HOH L . 
N 7 HOH 151 551 143 HOH HOH L . 
N 7 HOH 152 552 226 HOH HOH L . 
N 7 HOH 153 553 302 HOH HOH L . 
N 7 HOH 154 554 586 HOH HOH L . 
N 7 HOH 155 555 619 HOH HOH L . 
N 7 HOH 156 556 515 HOH HOH L . 
N 7 HOH 157 557 300 HOH HOH L . 
N 7 HOH 158 558 498 HOH HOH L . 
N 7 HOH 159 559 404 HOH HOH L . 
N 7 HOH 160 560 465 HOH HOH L . 
N 7 HOH 161 561 281 HOH HOH L . 
N 7 HOH 162 562 361 HOH HOH L . 
N 7 HOH 163 563 485 HOH HOH L . 
N 7 HOH 164 564 430 HOH HOH L . 
N 7 HOH 165 565 364 HOH HOH L . 
N 7 HOH 166 566 454 HOH HOH L . 
N 7 HOH 167 567 321 HOH HOH L . 
N 7 HOH 168 568 289 HOH HOH L . 
N 7 HOH 169 569 418 HOH HOH L . 
N 7 HOH 170 570 212 HOH HOH L . 
N 7 HOH 171 571 440 HOH HOH L . 
N 7 HOH 172 572 424 HOH HOH L . 
N 7 HOH 173 573 437 HOH HOH L . 
N 7 HOH 174 574 318 HOH HOH L . 
N 7 HOH 175 575 556 HOH HOH L . 
N 7 HOH 176 576 326 HOH HOH L . 
N 7 HOH 177 577 224 HOH HOH L . 
N 7 HOH 178 578 276 HOH HOH L . 
N 7 HOH 179 579 491 HOH HOH L . 
N 7 HOH 180 580 615 HOH HOH L . 
N 7 HOH 181 581 413 HOH HOH L . 
N 7 HOH 182 582 486 HOH HOH L . 
N 7 HOH 183 583 516 HOH HOH L . 
N 7 HOH 184 584 601 HOH HOH L . 
N 7 HOH 185 585 384 HOH HOH L . 
N 7 HOH 186 586 197 HOH HOH L . 
N 7 HOH 187 587 293 HOH HOH L . 
N 7 HOH 188 588 583 HOH HOH L . 
N 7 HOH 189 589 144 HOH HOH L . 
N 7 HOH 190 590 500 HOH HOH L . 
N 7 HOH 191 591 177 HOH HOH L . 
N 7 HOH 192 592 427 HOH HOH L . 
N 7 HOH 193 593 322 HOH HOH L . 
N 7 HOH 194 594 358 HOH HOH L . 
N 7 HOH 195 595 536 HOH HOH L . 
N 7 HOH 196 596 505 HOH HOH L . 
N 7 HOH 197 597 540 HOH HOH L . 
N 7 HOH 198 598 582 HOH HOH L . 
N 7 HOH 199 599 585 HOH HOH L . 
N 7 HOH 200 600 484 HOH HOH L . 
N 7 HOH 201 601 544 HOH HOH L . 
N 7 HOH 202 602 462 HOH HOH L . 
N 7 HOH 203 603 598 HOH HOH L . 
N 7 HOH 204 604 372 HOH HOH L . 
N 7 HOH 205 605 584 HOH HOH L . 
N 7 HOH 206 606 610 HOH HOH L . 
N 7 HOH 207 607 246 HOH HOH L . 
N 7 HOH 208 608 493 HOH HOH L . 
N 7 HOH 209 609 528 HOH HOH L . 
N 7 HOH 210 610 622 HOH HOH L . 
N 7 HOH 211 611 480 HOH HOH L . 
# 
_pdbx_unobs_or_zero_occ_atoms.id               1 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag     N 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id     H 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id     EDO 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id      301 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id     O2 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id     ? 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id    F 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id    EDO 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id     1 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id    O2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.2_5419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS      ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   93.482 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9MEV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     50.641 
_cell.length_a_esd                 ? 
_cell.length_b                     93.465 
_cell.length_b_esd                 ? 
_cell.length_c                     86.434 
_cell.length_c_esd                 ? 
_cell.volume                       408350.804 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9MEV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9MEV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.74 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.18 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M PCB, pH 6, 25% w/v PEG1500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-02-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 22-ID' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   22-ID 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          24.98 
_reflns.entry_id                                       9MEV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.06 
_reflns.d_resolution_low                               44.82 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     45825 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           92.14 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.067 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.987 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.06 
_reflns_shell.d_res_low                                     2.09 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             945 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.811 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.11 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9MEV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.06 
_refine.ls_d_res_low                             44.82 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     45825 
_refine.ls_number_reflns_R_free                  3152 
_refine.ls_number_reflns_R_work                  68608 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    72.90 
_refine.ls_percent_reflns_R_free                 4.39 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1821 
_refine.ls_R_factor_R_free                       0.2091 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1809 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.4274 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2160 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.06 
_refine_hist.d_res_low                        44.82 
_refine_hist.number_atoms_solvent             589 
_refine_hist.number_atoms_total               5699 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        5045 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         65 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0108  ? 5270 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2902  ? 7174 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0708  ? 801  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0056  ? 919  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.1010 ? 1962 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.06 2.09  . . 45  905  22.11 . . . . 0.3106 . . . . . . . . . . . 0.3444 
'X-RAY DIFFRACTION' 2.09 2.12  . . 56  1242 30.17 . . . . 0.2993 . . . . . . . . . . . 0.3280 
'X-RAY DIFFRACTION' 2.12 2.15  . . 70  1457 36.01 . . . . 0.2733 . . . . . . . . . . . 0.3226 
'X-RAY DIFFRACTION' 2.15 2.19  . . 69  1722 42.17 . . . . 0.2546 . . . . . . . . . . . 0.2611 
'X-RAY DIFFRACTION' 2.19 2.23  . . 88  1989 48.11 . . . . 0.2420 . . . . . . . . . . . 0.2646 
'X-RAY DIFFRACTION' 2.23 2.27  . . 100 2157 52.42 . . . . 0.2291 . . . . . . . . . . . 0.2475 
'X-RAY DIFFRACTION' 2.27 2.32  . . 99  2265 55.29 . . . . 0.2213 . . . . . . . . . . . 0.2586 
'X-RAY DIFFRACTION' 2.32 2.37  . . 120 2318 57.46 . . . . 0.2113 . . . . . . . . . . . 0.2329 
'X-RAY DIFFRACTION' 2.37 2.43  . . 113 2571 62.93 . . . . 0.2042 . . . . . . . . . . . 0.2518 
'X-RAY DIFFRACTION' 2.43 2.49  . . 130 2725 66.86 . . . . 0.2026 . . . . . . . . . . . 0.2327 
'X-RAY DIFFRACTION' 2.49 2.55  . . 139 2941 71.35 . . . . 0.2031 . . . . . . . . . . . 0.2180 
'X-RAY DIFFRACTION' 2.55 2.63  . . 125 3158 77.08 . . . . 0.1997 . . . . . . . . . . . 0.2469 
'X-RAY DIFFRACTION' 2.63 2.71  . . 179 3570 87.68 . . . . 0.2003 . . . . . . . . . . . 0.1996 
'X-RAY DIFFRACTION' 2.71 2.81  . . 165 3852 92.75 . . . . 0.2027 . . . . . . . . . . . 0.2153 
'X-RAY DIFFRACTION' 2.81 2.92  . . 186 3831 95.30 . . . . 0.1918 . . . . . . . . . . . 0.2174 
'X-RAY DIFFRACTION' 2.92 3.06  . . 180 3986 97.38 . . . . 0.1891 . . . . . . . . . . . 0.2231 
'X-RAY DIFFRACTION' 3.06 3.22  . . 176 4091 98.36 . . . . 0.1789 . . . . . . . . . . . 0.2521 
'X-RAY DIFFRACTION' 3.22 3.42  . . 181 3960 98.08 . . . . 0.1716 . . . . . . . . . . . 0.2367 
'X-RAY DIFFRACTION' 3.42 3.68  . . 190 3907 95.66 . . . . 0.1647 . . . . . . . . . . . 0.1815 
'X-RAY DIFFRACTION' 3.68 4.05  . . 179 3946 95.86 . . . . 0.1565 . . . . . . . . . . . 0.1889 
'X-RAY DIFFRACTION' 4.05 4.64  . . 190 4066 99.02 . . . . 0.1426 . . . . . . . . . . . 0.1571 
'X-RAY DIFFRACTION' 4.64 5.84  . . 186 4029 99.13 . . . . 0.1586 . . . . . . . . . . . 0.1525 
'X-RAY DIFFRACTION' 5.84 44.82 . . 186 3920 95.71 . . . . 0.1873 . . . . . . . . . . . 0.2348 
# 
_struct.entry_id                     9MEV 
_struct.title                        'Structure of H1H3:FluA20 Chimeric Antigen Complex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9MEV 
_struct_keywords.text            'Influenza, HA, Hemagglutinin, Antigen, Antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN/IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 6 ? 
H N N 6 ? 
I N N 6 ? 
J N N 6 ? 
K N N 6 ? 
L N N 7 ? 
M N N 7 ? 
N N N 7 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9MEV 9MEV ? 1 ? 1 
2 PDB 9MEV 9MEV ? 2 ? 1 
3 PDB 9MEV 9MEV ? 3 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9MEV B 1 ? 227 ? 9MEV 52 ? 278 ? 52 278 
2 2 9MEV H 1 ? 235 ? 9MEV 1  ? 222 ? 1  222 
3 3 9MEV L 1 ? 214 ? 9MEV 1  ? 214 ? 1  214 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? GLY A 16  ? SER B 60  GLY B 67  1 ? 8  
HELX_P HELX_P2  AA2 ASN A 17  ? GLU A 21  ? ASN B 68  GLU B 72  5 ? 5  
HELX_P HELX_P3  AA3 ASP A 50  ? LEU A 58  ? ASP B 101 LEU B 109 1 ? 9  
HELX_P HELX_P4  AA4 PRO A 71  ? TRP A 76  ? PRO B 122 TRP B 127 1 ? 6  
HELX_P HELX_P5  AA5 THR A 136 ? VAL A 145 ? THR B 187 VAL B 196 1 ? 10 
HELX_P HELX_P6  AA6 LEU B 65  ? SER B 67  ? LEU H 63  SER H 65  5 ? 3  
HELX_P HELX_P7  AA7 THR B 88  ? THR B 92  ? THR H 83  THR H 87  5 ? 5  
HELX_P HELX_P8  AA8 SER B 140 ? THR B 144 ? SER H 127 THR H 131 5 ? 5  
HELX_P HELX_P9  AA9 SER B 169 ? ALA B 171 ? SER H 156 ALA H 158 5 ? 3  
HELX_P HELX_P10 AB1 PRO B 198 ? LEU B 202 ? PRO H 185 LEU H 189 5 ? 5  
HELX_P HELX_P11 AB2 LYS B 214 ? ASN B 217 ? LYS H 201 ASN H 204 5 ? 4  
HELX_P HELX_P12 AB3 GLN C 79  ? PHE C 83  ? GLN L 79  PHE L 83  5 ? 5  
HELX_P HELX_P13 AB4 SER C 121 ? LYS C 126 ? SER L 121 LYS L 126 1 ? 6  
HELX_P HELX_P14 AB5 LYS C 183 ? LYS C 188 ? LYS L 183 LYS L 188 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 8   SG  ? ? ? 1_555 A CYS 20  SG ? ? B CYS 59  B CYS 71  1_555 ? ? ? ? ? ? ? 2.014 ? ?               
disulf2 disulf ?    ? A CYS 43  SG  ? ? ? 1_555 A CYS 88  SG ? ? B CYS 94  B CYS 139 1_555 ? ? ? ? ? ? ? 2.047 ? ?               
disulf3 disulf ?    ? B CYS 22  SG  ? ? ? 1_555 B CYS 97  SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.043 ? ?               
disulf4 disulf ?    ? B CYS 107 SG  ? B ? 1_555 B CYS 112 SG ? G H CYS 100 H CYS 100 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf5 disulf ?    ? B CYS 153 SG  ? ? ? 1_555 B CYS 209 SG ? ? H CYS 140 H CYS 196 1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf6 disulf ?    ? C CYS 23  SG  ? ? ? 1_555 C CYS 88  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.048 ? ?               
disulf7 disulf ?    ? C CYS 134 SG  ? ? ? 1_555 C CYS 194 SG ? ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.015 ? ?               
covale1 covale one  ? A ASN 7   ND2 ? ? ? 1_555 E NAG .   C1 ? ? B ASN 58  B NAG 301 1_555 ? ? ? ? ? ? ? 1.445 ? N-Glycosylation 
covale2 covale one  ? A ASN 40  ND2 ? ? ? 1_555 D NAG .   C1 ? ? B ASN 91  A NAG 1   1_555 ? ? ? ? ? ? ? 1.433 ? N-Glycosylation 
covale3 covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? A NAG 1   A NAG 2   1_555 ? ? ? ? ? ? ? 1.433 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG D .   ? ASN A 40  ? NAG A 1   ? 1_555 ASN B 91  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG E .   ? ASN A 7   ? NAG B 301 ? 1_555 ASN B 58  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 CYS A 8   ? CYS A 20  ? CYS B 59  ? 1_555 CYS B 71  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 43  ? CYS A 88  ? CYS B 94  ? 1_555 CYS B 139 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS B 22  ? CYS B 97  ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6 CYS B 107 ? CYS B 112 ? CYS H 100 B 1_555 CYS H 100 G 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7 CYS B 153 ? CYS B 209 ? CYS H 140 ? 1_555 CYS H 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8 CYS C 23  ? CYS C 88  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9 CYS C 134 ? CYS C 194 ? CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 159 B . ? PHE 146 H PRO 160 B ? PRO 147 H 1 -12.22 
2 GLU 161 B . ? GLU 148 H PRO 162 B ? PRO 149 H 1 11.11  
3 SER 7   C . ? SER 7   L PRO 8   C ? PRO 8   L 1 -0.70  
4 THR 94  C . ? THR 94  L PRO 95  C ? PRO 95  L 1 2.87   
5 TYR 140 C . ? TYR 140 L PRO 141 C ? PRO 141 L 1 3.87   
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 7 ? 
AA3 ? 5 ? 
AA4 ? 2 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 6 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 3 ? 
AB3 ? 4 ? 
AB4 ? 6 ? 
AB5 ? 4 ? 
AB6 ? 4 ? 
AB7 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA7 5 6 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? parallel      
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB4 4 5 ? anti-parallel 
AB4 5 6 ? anti-parallel 
AB5 1 2 ? parallel      
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
AB6 1 2 ? anti-parallel 
AB6 2 3 ? anti-parallel 
AB6 3 4 ? anti-parallel 
AB7 1 2 ? anti-parallel 
AB7 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 3   ? GLN A 4   ? LEU B 54  GLN B 55  
AA1 2 ILE A 32  ? VAL A 33  ? ILE B 83  VAL B 84  
AA2 1 TRP A 29  ? SER A 30  ? TRP B 80  SER B 81  
AA2 2 SER A 60  ? PHE A 67  ? SER B 111 PHE B 118 
AA2 3 ALA A 206 ? ARG A 211 ? ALA B 257 ARG B 262 
AA2 4 GLU A 124 ? HIS A 133 ? GLU B 175 HIS B 184 
AA2 5 LEU A 200 ? PRO A 203 ? LEU B 251 PRO B 254 
AA2 6 LEU A 100 ? THR A 104 ? LEU B 151 THR B 155 
AA2 7 THR A 80  ? GLN A 81  ? THR B 131 GLN B 132 
AA3 1 TRP A 29  ? SER A 30  ? TRP B 80  SER B 81  
AA3 2 SER A 60  ? PHE A 67  ? SER B 111 PHE B 118 
AA3 3 ALA A 206 ? ARG A 211 ? ALA B 257 ARG B 262 
AA3 4 GLU A 124 ? HIS A 133 ? GLU B 175 HIS B 184 
AA3 5 ARG A 178 ? LEU A 186 ? ARG B 229 LEU B 237 
AA4 1 SER A 85  ? HIS A 90  ? SER B 136 HIS B 141 
AA4 2 GLU A 93  ? SER A 95  ? GLU B 144 SER B 146 
AA5 1 LEU A 113 ? ALA A 118 ? LEU B 164 ALA B 169 
AA5 2 THR A 191 ? ALA A 196 ? THR B 242 ALA B 247 
AA5 3 VAL A 151 ? VAL A 154 ? VAL B 202 VAL B 205 
AA5 4 SER A 159 ? PHE A 162 ? SER B 210 PHE B 213 
AA6 1 GLN B 3   ? GLU B 6   ? GLN H 3   GLU H 6   
AA6 2 LEU B 18  ? SER B 25  ? LEU H 18  SER H 25  
AA6 3 GLU B 79  ? LEU B 84  ? GLU H 77  LEU H 82  
AA6 4 VAL B 69  ? ASP B 74  ? VAL H 67  ASP H 72  
AA7 1 GLY B 10  ? VAL B 12  ? GLY H 10  VAL H 12  
AA7 2 THR B 120 ? VAL B 124 ? THR H 107 VAL H 111 
AA7 3 ALA B 93  ? THR B 101 ? ALA H 88  THR H 96  
AA7 4 TYR B 34  ? GLN B 41  ? TYR H 34  GLN H 39  
AA7 5 GLU B 48  ? ILE B 53  ? GLU H 46  ILE H 51  
AA7 6 THR B 59  ? TYR B 61  ? THR H 57  TYR H 59  
AA8 1 GLY B 10  ? VAL B 12  ? GLY H 10  VAL H 12  
AA8 2 THR B 120 ? VAL B 124 ? THR H 107 VAL H 111 
AA8 3 ALA B 93  ? THR B 101 ? ALA H 88  THR H 96  
AA8 4 HIS B 115 ? TRP B 116 ? HIS H 102 TRP H 103 
AA9 1 SER B 133 ? LEU B 137 ? SER H 120 LEU H 124 
AA9 2 ALA B 149 ? TYR B 158 ? ALA H 136 TYR H 145 
AA9 3 TYR B 189 ? VAL B 197 ? TYR H 176 VAL H 184 
AA9 4 VAL B 176 ? THR B 178 ? VAL H 163 THR H 165 
AB1 1 SER B 133 ? LEU B 137 ? SER H 120 LEU H 124 
AB1 2 ALA B 149 ? TYR B 158 ? ALA H 136 TYR H 145 
AB1 3 TYR B 189 ? VAL B 197 ? TYR H 176 VAL H 184 
AB1 4 VAL B 182 ? LEU B 183 ? VAL H 169 LEU H 170 
AB2 1 THR B 164 ? TRP B 167 ? THR H 151 TRP H 154 
AB2 2 ILE B 208 ? HIS B 213 ? ILE H 195 HIS H 200 
AB2 3 THR B 218 ? ARG B 223 ? THR H 205 ARG H 210 
AB3 1 MET C 4   ? SER C 7   ? MET L 4   SER L 7   
AB3 2 VAL C 19  ? PRO C 25  ? VAL L 19  PRO L 25  
AB3 3 GLU C 70  ? ILE C 75  ? GLU L 70  ILE L 75  
AB3 4 PHE C 62  ? SER C 67  ? PHE L 62  SER L 67  
AB4 1 SER C 10  ? SER C 14  ? SER L 10  SER L 14  
AB4 2 THR C 102 ? LYS C 107 ? THR L 102 LYS L 107 
AB4 3 ALA C 84  ? GLN C 90  ? ALA L 84  GLN L 90  
AB4 4 LEU C 33  ? HIS C 38  ? LEU L 33  HIS L 38  
AB4 5 LYS C 45  ? TYR C 49  ? LYS L 45  TYR L 49  
AB4 6 ASN C 53  ? LEU C 54  ? ASN L 53  LEU L 54  
AB5 1 SER C 10  ? SER C 14  ? SER L 10  SER L 14  
AB5 2 THR C 102 ? LYS C 107 ? THR L 102 LYS L 107 
AB5 3 ALA C 84  ? GLN C 90  ? ALA L 84  GLN L 90  
AB5 4 THR C 97  ? PHE C 98  ? THR L 97  PHE L 98  
AB6 1 SER C 114 ? PHE C 118 ? SER L 114 PHE L 118 
AB6 2 THR C 129 ? PHE C 139 ? THR L 129 PHE L 139 
AB6 3 TYR C 173 ? SER C 182 ? TYR L 173 SER L 182 
AB6 4 SER C 159 ? VAL C 163 ? SER L 159 VAL L 163 
AB7 1 LYS C 145 ? VAL C 150 ? LYS L 145 VAL L 150 
AB7 2 VAL C 191 ? THR C 197 ? VAL L 191 THR L 197 
AB7 3 VAL C 205 ? ASN C 210 ? VAL L 205 ASN L 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 3   ? N LEU B 54  O VAL A 33  ? O VAL B 84  
AA2 1 2 N TRP A 29  ? N TRP B 80  O VAL A 61  ? O VAL B 112 
AA2 2 3 N SER A 62  ? N SER B 113 O SER A 210 ? O SER B 261 
AA2 3 4 O PHE A 207 ? O PHE B 258 N LEU A 126 ? N LEU B 177 
AA2 4 5 N GLY A 130 ? N GLY B 181 O ILE A 201 ? O ILE B 252 
AA2 5 6 O ALA A 202 ? O ALA B 253 N LEU A 101 ? N LEU B 152 
AA2 6 7 O THR A 104 ? O THR B 155 N THR A 80  ? N THR B 131 
AA3 1 2 N TRP A 29  ? N TRP B 80  O VAL A 61  ? O VAL B 112 
AA3 2 3 N SER A 62  ? N SER B 113 O SER A 210 ? O SER B 261 
AA3 3 4 O PHE A 207 ? O PHE B 258 N LEU A 126 ? N LEU B 177 
AA3 4 5 N VAL A 125 ? N VAL B 176 O LEU A 186 ? O LEU B 237 
AA4 1 2 N HIS A 90  ? N HIS B 141 O GLU A 93  ? O GLU B 144 
AA5 1 2 N LYS A 115 ? N LYS B 166 O PHE A 194 ? O PHE B 245 
AA5 2 3 O GLU A 195 ? O GLU B 246 N SER A 152 ? N SER B 203 
AA5 3 4 N VAL A 151 ? N VAL B 202 O PHE A 162 ? O PHE B 213 
AA6 1 2 N GLU B 5   ? N GLU H 5   O SER B 23  ? O SER H 23  
AA6 2 3 N CYS B 22  ? N CYS H 22  O PHE B 80  ? O PHE H 78  
AA6 3 4 O GLU B 79  ? O GLU H 77  N ASP B 74  ? N ASP H 72  
AA7 1 2 N GLY B 10  ? N GLY H 10  O THR B 123 ? O THR H 110 
AA7 2 3 O THR B 120 ? O THR H 107 N TYR B 95  ? N TYR H 90  
AA7 3 4 O PHE B 96  ? O PHE H 91  N ILE B 39  ? N ILE H 37  
AA7 4 5 N ARG B 40  ? N ARG H 38  O GLU B 48  ? O GLU H 46  
AA7 5 6 N TYR B 52  ? N TYR H 50  O ASN B 60  ? O ASN H 58  
AA8 1 2 N GLY B 10  ? N GLY H 10  O THR B 123 ? O THR H 110 
AA8 2 3 O THR B 120 ? O THR H 107 N TYR B 95  ? N TYR H 90  
AA8 3 4 N ARG B 99  ? N ARG H 94  O HIS B 115 ? O HIS H 102 
AA9 1 2 N LEU B 137 ? N LEU H 124 O GLY B 152 ? O GLY H 139 
AA9 2 3 N ALA B 149 ? N ALA H 136 O VAL B 197 ? O VAL H 184 
AA9 3 4 O VAL B 194 ? O VAL H 181 N HIS B 177 ? N HIS H 164 
AB1 1 2 N LEU B 137 ? N LEU H 124 O GLY B 152 ? O GLY H 139 
AB1 2 3 N ALA B 149 ? N ALA H 136 O VAL B 197 ? O VAL H 184 
AB1 3 4 O SER B 190 ? O SER H 177 N VAL B 182 ? N VAL H 169 
AB2 1 2 N SER B 166 ? N SER H 153 O ASN B 210 ? O ASN H 197 
AB2 2 3 N VAL B 211 ? N VAL H 198 O VAL B 220 ? O VAL H 207 
AB3 1 2 N SER C 7   ? N SER L 7   O THR C 22  ? O THR L 22  
AB3 2 3 N VAL C 19  ? N VAL L 19  O ILE C 75  ? O ILE L 75  
AB3 3 4 O THR C 74  ? O THR L 74  N SER C 63  ? N SER L 63  
AB4 1 2 N ALA C 13  ? N ALA L 13  O LYS C 107 ? O LYS L 107 
AB4 2 3 O VAL C 104 ? O VAL L 104 N ALA C 84  ? N ALA L 84  
AB4 3 4 O TYR C 87  ? O TYR L 87  N PHE C 36  ? N PHE L 36  
AB4 4 5 N GLN C 37  ? N GLN L 37  O LYS C 45  ? O LYS L 45  
AB4 5 6 N TYR C 49  ? N TYR L 49  O ASN C 53  ? O ASN L 53  
AB5 1 2 N ALA C 13  ? N ALA L 13  O LYS C 107 ? O LYS L 107 
AB5 2 3 O VAL C 104 ? O VAL L 104 N ALA C 84  ? N ALA L 84  
AB5 3 4 N GLN C 90  ? N GLN L 90  O THR C 97  ? O THR L 97  
AB6 1 2 N PHE C 116 ? N PHE L 116 O LEU C 135 ? O LEU L 135 
AB6 2 3 N ALA C 130 ? N ALA L 130 O LEU C 181 ? O LEU L 181 
AB6 3 4 O THR C 178 ? O THR L 178 N GLN C 160 ? N GLN L 160 
AB7 1 2 N LYS C 149 ? N LYS L 149 O ALA C 193 ? O ALA L 193 
AB7 2 3 N VAL C 196 ? N VAL L 196 O VAL C 205 ? O VAL L 205 
# 
_pdbx_entry_details.entry_id                   9MEV 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O L HOH 533 ? ? O L HOH 581 ? ? 1.83 
2  1 O L HOH 526 ? ? O L HOH 576 ? ? 1.84 
3  1 O B HOH 525 ? ? O B HOH 547 ? ? 1.92 
4  1 O B HOH 529 ? ? O B HOH 543 ? ? 1.96 
5  1 O H HOH 454 ? ? O H HOH 588 ? ? 1.97 
6  1 O L HOH 474 ? ? O L HOH 502 ? ? 1.99 
7  1 O B HOH 504 ? ? O B HOH 516 ? ? 2.00 
8  1 O H HOH 533 ? ? O H HOH 557 ? ? 2.05 
9  1 O H HOH 482 ? ? O H HOH 585 ? ? 2.09 
10 1 O B HOH 474 ? ? O B HOH 485 ? ? 2.11 
11 1 O B HOH 401 ? ? O B HOH 539 ? ? 2.11 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OD2 
_pdbx_validate_symm_contact.auth_asym_id_1    H 
_pdbx_validate_symm_contact.auth_comp_id_1    ASP 
_pdbx_validate_symm_contact.auth_seq_id_1     56 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    H 
_pdbx_validate_symm_contact.auth_comp_id_2    GLY 
_pdbx_validate_symm_contact.auth_seq_id_2     133 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_645 
_pdbx_validate_symm_contact.dist              1.96 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TYR B 82  ? ? 77.57   127.42  
2  1 CYS B 139 ? ? -119.31 57.27   
3  1 SER B 146 ? ? -143.90 -157.95 
4  1 VAL B 196 ? ? 67.94   -58.67  
5  1 SER B 210 ? ? -162.13 116.04  
6  1 SER H 15  ? ? 70.90   -1.99   
7  1 ASN H 54  ? ? -67.96  0.87    
8  1 ASP H 98  ? ? -154.00 67.95   
9  1 ARG L 30  ? ? 57.31   -119.68 
10 1 ALA L 51  ? ? 75.61   -37.18  
11 1 SER L 52  ? ? -143.23 -0.50   
12 1 LYS L 126 ? ? -67.77  0.26    
13 1 ASN L 138 ? ? 55.38   75.77   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1  1 O ? B HOH 558 ? 5.85  .    
2  1 O ? B HOH 559 ? 6.76  .    
3  1 O ? B HOH 560 ? 7.66  .    
4  1 O ? B HOH 561 ? 7.83  .    
5  1 O ? B HOH 562 ? 8.29  .    
6  1 O ? B HOH 563 ? .     8.30 
7  1 O ? B HOH 565 ? .     8.06 
8  1 O ? H HOH 606 ? 5.93  .    
9  1 O ? H HOH 607 ? 5.99  .    
10 1 O ? H HOH 608 ? 6.89  .    
11 1 O ? H HOH 609 ? 7.19  .    
12 1 O ? H HOH 610 ? 8.17  .    
13 1 O ? H HOH 611 ? 8.23  .    
14 1 O ? H HOH 612 ? 9.11  .    
15 1 O ? H HOH 613 ? 10.47 .    
16 1 O ? L HOH 606 ? 6.29  .    
17 1 O ? L HOH 608 ? 7.79  .    
18 1 O ? L HOH 609 ? .     7.63 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B SER 264 ? A SER 213 
2  1 Y 1 B GLY 265 ? A GLY 214 
3  1 Y 1 B LEU 266 ? A LEU 215 
4  1 Y 1 B VAL 267 ? A VAL 216 
5  1 Y 1 B PRO 268 ? A PRO 217 
6  1 Y 1 B ARG 269 ? A ARG 218 
7  1 Y 1 B GLY 270 ? A GLY 219 
8  1 Y 1 B SER 271 ? A SER 220 
9  1 Y 1 B GLY 272 ? A GLY 221 
10 1 Y 1 B HIS 273 ? A HIS 222 
11 1 Y 1 B HIS 274 ? A HIS 223 
12 1 Y 1 B HIS 275 ? A HIS 224 
13 1 Y 1 B HIS 276 ? A HIS 225 
14 1 Y 1 B HIS 277 ? A HIS 226 
15 1 Y 1 B HIS 278 ? A HIS 227 
16 1 Y 1 H SER 215 ? B SER 228 
17 1 Y 1 H CYS 216 ? B CYS 229 
18 1 Y 1 H HIS 217 ? B HIS 230 
19 1 Y 1 H HIS 218 ? B HIS 231 
20 1 Y 1 H HIS 219 ? B HIS 232 
21 1 Y 1 H HIS 220 ? B HIS 233 
22 1 Y 1 H HIS 221 ? B HIS 234 
23 1 Y 1 H HIS 222 ? B HIS 235 
24 1 Y 1 L CYS 214 ? C CYS 214 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
EDO C1   C N N 88  
EDO O1   O N N 89  
EDO C2   C N N 90  
EDO O2   O N N 91  
EDO H11  H N N 92  
EDO H12  H N N 93  
EDO HO1  H N N 94  
EDO H21  H N N 95  
EDO H22  H N N 96  
EDO HO2  H N N 97  
GLN N    N N N 98  
GLN CA   C N S 99  
GLN C    C N N 100 
GLN O    O N N 101 
GLN CB   C N N 102 
GLN CG   C N N 103 
GLN CD   C N N 104 
GLN OE1  O N N 105 
GLN NE2  N N N 106 
GLN OXT  O N N 107 
GLN H    H N N 108 
GLN H2   H N N 109 
GLN HA   H N N 110 
GLN HB2  H N N 111 
GLN HB3  H N N 112 
GLN HG2  H N N 113 
GLN HG3  H N N 114 
GLN HE21 H N N 115 
GLN HE22 H N N 116 
GLN HXT  H N N 117 
GLU N    N N N 118 
GLU CA   C N S 119 
GLU C    C N N 120 
GLU O    O N N 121 
GLU CB   C N N 122 
GLU CG   C N N 123 
GLU CD   C N N 124 
GLU OE1  O N N 125 
GLU OE2  O N N 126 
GLU OXT  O N N 127 
GLU H    H N N 128 
GLU H2   H N N 129 
GLU HA   H N N 130 
GLU HB2  H N N 131 
GLU HB3  H N N 132 
GLU HG2  H N N 133 
GLU HG3  H N N 134 
GLU HE2  H N N 135 
GLU HXT  H N N 136 
GLY N    N N N 137 
GLY CA   C N N 138 
GLY C    C N N 139 
GLY O    O N N 140 
GLY OXT  O N N 141 
GLY H    H N N 142 
GLY H2   H N N 143 
GLY HA2  H N N 144 
GLY HA3  H N N 145 
GLY HXT  H N N 146 
HIS N    N N N 147 
HIS CA   C N S 148 
HIS C    C N N 149 
HIS O    O N N 150 
HIS CB   C N N 151 
HIS CG   C Y N 152 
HIS ND1  N Y N 153 
HIS CD2  C Y N 154 
HIS CE1  C Y N 155 
HIS NE2  N Y N 156 
HIS OXT  O N N 157 
HIS H    H N N 158 
HIS H2   H N N 159 
HIS HA   H N N 160 
HIS HB2  H N N 161 
HIS HB3  H N N 162 
HIS HD1  H N N 163 
HIS HD2  H N N 164 
HIS HE1  H N N 165 
HIS HE2  H N N 166 
HIS HXT  H N N 167 
HOH O    O N N 168 
HOH H1   H N N 169 
HOH H2   H N N 170 
ILE N    N N N 171 
ILE CA   C N S 172 
ILE C    C N N 173 
ILE O    O N N 174 
ILE CB   C N S 175 
ILE CG1  C N N 176 
ILE CG2  C N N 177 
ILE CD1  C N N 178 
ILE OXT  O N N 179 
ILE H    H N N 180 
ILE H2   H N N 181 
ILE HA   H N N 182 
ILE HB   H N N 183 
ILE HG12 H N N 184 
ILE HG13 H N N 185 
ILE HG21 H N N 186 
ILE HG22 H N N 187 
ILE HG23 H N N 188 
ILE HD11 H N N 189 
ILE HD12 H N N 190 
ILE HD13 H N N 191 
ILE HXT  H N N 192 
LEU N    N N N 193 
LEU CA   C N S 194 
LEU C    C N N 195 
LEU O    O N N 196 
LEU CB   C N N 197 
LEU CG   C N N 198 
LEU CD1  C N N 199 
LEU CD2  C N N 200 
LEU OXT  O N N 201 
LEU H    H N N 202 
LEU H2   H N N 203 
LEU HA   H N N 204 
LEU HB2  H N N 205 
LEU HB3  H N N 206 
LEU HG   H N N 207 
LEU HD11 H N N 208 
LEU HD12 H N N 209 
LEU HD13 H N N 210 
LEU HD21 H N N 211 
LEU HD22 H N N 212 
LEU HD23 H N N 213 
LEU HXT  H N N 214 
LYS N    N N N 215 
LYS CA   C N S 216 
LYS C    C N N 217 
LYS O    O N N 218 
LYS CB   C N N 219 
LYS CG   C N N 220 
LYS CD   C N N 221 
LYS CE   C N N 222 
LYS NZ   N N N 223 
LYS OXT  O N N 224 
LYS H    H N N 225 
LYS H2   H N N 226 
LYS HA   H N N 227 
LYS HB2  H N N 228 
LYS HB3  H N N 229 
LYS HG2  H N N 230 
LYS HG3  H N N 231 
LYS HD2  H N N 232 
LYS HD3  H N N 233 
LYS HE2  H N N 234 
LYS HE3  H N N 235 
LYS HZ1  H N N 236 
LYS HZ2  H N N 237 
LYS HZ3  H N N 238 
LYS HXT  H N N 239 
MET N    N N N 240 
MET CA   C N S 241 
MET C    C N N 242 
MET O    O N N 243 
MET CB   C N N 244 
MET CG   C N N 245 
MET SD   S N N 246 
MET CE   C N N 247 
MET OXT  O N N 248 
MET H    H N N 249 
MET H2   H N N 250 
MET HA   H N N 251 
MET HB2  H N N 252 
MET HB3  H N N 253 
MET HG2  H N N 254 
MET HG3  H N N 255 
MET HE1  H N N 256 
MET HE2  H N N 257 
MET HE3  H N N 258 
MET HXT  H N N 259 
NAG C1   C N R 260 
NAG C2   C N R 261 
NAG C3   C N R 262 
NAG C4   C N S 263 
NAG C5   C N R 264 
NAG C6   C N N 265 
NAG C7   C N N 266 
NAG C8   C N N 267 
NAG N2   N N N 268 
NAG O1   O N N 269 
NAG O3   O N N 270 
NAG O4   O N N 271 
NAG O5   O N N 272 
NAG O6   O N N 273 
NAG O7   O N N 274 
NAG H1   H N N 275 
NAG H2   H N N 276 
NAG H3   H N N 277 
NAG H4   H N N 278 
NAG H5   H N N 279 
NAG H61  H N N 280 
NAG H62  H N N 281 
NAG H81  H N N 282 
NAG H82  H N N 283 
NAG H83  H N N 284 
NAG HN2  H N N 285 
NAG HO1  H N N 286 
NAG HO3  H N N 287 
NAG HO4  H N N 288 
NAG HO6  H N N 289 
PHE N    N N N 290 
PHE CA   C N S 291 
PHE C    C N N 292 
PHE O    O N N 293 
PHE CB   C N N 294 
PHE CG   C Y N 295 
PHE CD1  C Y N 296 
PHE CD2  C Y N 297 
PHE CE1  C Y N 298 
PHE CE2  C Y N 299 
PHE CZ   C Y N 300 
PHE OXT  O N N 301 
PHE H    H N N 302 
PHE H2   H N N 303 
PHE HA   H N N 304 
PHE HB2  H N N 305 
PHE HB3  H N N 306 
PHE HD1  H N N 307 
PHE HD2  H N N 308 
PHE HE1  H N N 309 
PHE HE2  H N N 310 
PHE HZ   H N N 311 
PHE HXT  H N N 312 
PRO N    N N N 313 
PRO CA   C N S 314 
PRO C    C N N 315 
PRO O    O N N 316 
PRO CB   C N N 317 
PRO CG   C N N 318 
PRO CD   C N N 319 
PRO OXT  O N N 320 
PRO H    H N N 321 
PRO HA   H N N 322 
PRO HB2  H N N 323 
PRO HB3  H N N 324 
PRO HG2  H N N 325 
PRO HG3  H N N 326 
PRO HD2  H N N 327 
PRO HD3  H N N 328 
PRO HXT  H N N 329 
SER N    N N N 330 
SER CA   C N S 331 
SER C    C N N 332 
SER O    O N N 333 
SER CB   C N N 334 
SER OG   O N N 335 
SER OXT  O N N 336 
SER H    H N N 337 
SER H2   H N N 338 
SER HA   H N N 339 
SER HB2  H N N 340 
SER HB3  H N N 341 
SER HG   H N N 342 
SER HXT  H N N 343 
THR N    N N N 344 
THR CA   C N S 345 
THR C    C N N 346 
THR O    O N N 347 
THR CB   C N R 348 
THR OG1  O N N 349 
THR CG2  C N N 350 
THR OXT  O N N 351 
THR H    H N N 352 
THR H2   H N N 353 
THR HA   H N N 354 
THR HB   H N N 355 
THR HG1  H N N 356 
THR HG21 H N N 357 
THR HG22 H N N 358 
THR HG23 H N N 359 
THR HXT  H N N 360 
TRP N    N N N 361 
TRP CA   C N S 362 
TRP C    C N N 363 
TRP O    O N N 364 
TRP CB   C N N 365 
TRP CG   C Y N 366 
TRP CD1  C Y N 367 
TRP CD2  C Y N 368 
TRP NE1  N Y N 369 
TRP CE2  C Y N 370 
TRP CE3  C Y N 371 
TRP CZ2  C Y N 372 
TRP CZ3  C Y N 373 
TRP CH2  C Y N 374 
TRP OXT  O N N 375 
TRP H    H N N 376 
TRP H2   H N N 377 
TRP HA   H N N 378 
TRP HB2  H N N 379 
TRP HB3  H N N 380 
TRP HD1  H N N 381 
TRP HE1  H N N 382 
TRP HE3  H N N 383 
TRP HZ2  H N N 384 
TRP HZ3  H N N 385 
TRP HH2  H N N 386 
TRP HXT  H N N 387 
TYR N    N N N 388 
TYR CA   C N S 389 
TYR C    C N N 390 
TYR O    O N N 391 
TYR CB   C N N 392 
TYR CG   C Y N 393 
TYR CD1  C Y N 394 
TYR CD2  C Y N 395 
TYR CE1  C Y N 396 
TYR CE2  C Y N 397 
TYR CZ   C Y N 398 
TYR OH   O N N 399 
TYR OXT  O N N 400 
TYR H    H N N 401 
TYR H2   H N N 402 
TYR HA   H N N 403 
TYR HB2  H N N 404 
TYR HB3  H N N 405 
TYR HD1  H N N 406 
TYR HD2  H N N 407 
TYR HE1  H N N 408 
TYR HE2  H N N 409 
TYR HH   H N N 410 
TYR HXT  H N N 411 
VAL N    N N N 412 
VAL CA   C N S 413 
VAL C    C N N 414 
VAL O    O N N 415 
VAL CB   C N N 416 
VAL CG1  C N N 417 
VAL CG2  C N N 418 
VAL OXT  O N N 419 
VAL H    H N N 420 
VAL H2   H N N 421 
VAL HA   H N N 422 
VAL HB   H N N 423 
VAL HG11 H N N 424 
VAL HG12 H N N 425 
VAL HG13 H N N 426 
VAL HG21 H N N 427 
VAL HG22 H N N 428 
VAL HG23 H N N 429 
VAL HXT  H N N 430 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
NAG C1  C2   sing N N 246 
NAG C1  O1   sing N N 247 
NAG C1  O5   sing N N 248 
NAG C1  H1   sing N N 249 
NAG C2  C3   sing N N 250 
NAG C2  N2   sing N N 251 
NAG C2  H2   sing N N 252 
NAG C3  C4   sing N N 253 
NAG C3  O3   sing N N 254 
NAG C3  H3   sing N N 255 
NAG C4  C5   sing N N 256 
NAG C4  O4   sing N N 257 
NAG C4  H4   sing N N 258 
NAG C5  C6   sing N N 259 
NAG C5  O5   sing N N 260 
NAG C5  H5   sing N N 261 
NAG C6  O6   sing N N 262 
NAG C6  H61  sing N N 263 
NAG C6  H62  sing N N 264 
NAG C7  C8   sing N N 265 
NAG C7  N2   sing N N 266 
NAG C7  O7   doub N N 267 
NAG C8  H81  sing N N 268 
NAG C8  H82  sing N N 269 
NAG C8  H83  sing N N 270 
NAG N2  HN2  sing N N 271 
NAG O1  HO1  sing N N 272 
NAG O3  HO3  sing N N 273 
NAG O4  HO4  sing N N 274 
NAG O6  HO6  sing N N 275 
PHE N   CA   sing N N 276 
PHE N   H    sing N N 277 
PHE N   H2   sing N N 278 
PHE CA  C    sing N N 279 
PHE CA  CB   sing N N 280 
PHE CA  HA   sing N N 281 
PHE C   O    doub N N 282 
PHE C   OXT  sing N N 283 
PHE CB  CG   sing N N 284 
PHE CB  HB2  sing N N 285 
PHE CB  HB3  sing N N 286 
PHE CG  CD1  doub Y N 287 
PHE CG  CD2  sing Y N 288 
PHE CD1 CE1  sing Y N 289 
PHE CD1 HD1  sing N N 290 
PHE CD2 CE2  doub Y N 291 
PHE CD2 HD2  sing N N 292 
PHE CE1 CZ   doub Y N 293 
PHE CE1 HE1  sing N N 294 
PHE CE2 CZ   sing Y N 295 
PHE CE2 HE2  sing N N 296 
PHE CZ  HZ   sing N N 297 
PHE OXT HXT  sing N N 298 
PRO N   CA   sing N N 299 
PRO N   CD   sing N N 300 
PRO N   H    sing N N 301 
PRO CA  C    sing N N 302 
PRO CA  CB   sing N N 303 
PRO CA  HA   sing N N 304 
PRO C   O    doub N N 305 
PRO C   OXT  sing N N 306 
PRO CB  CG   sing N N 307 
PRO CB  HB2  sing N N 308 
PRO CB  HB3  sing N N 309 
PRO CG  CD   sing N N 310 
PRO CG  HG2  sing N N 311 
PRO CG  HG3  sing N N 312 
PRO CD  HD2  sing N N 313 
PRO CD  HD3  sing N N 314 
PRO OXT HXT  sing N N 315 
SER N   CA   sing N N 316 
SER N   H    sing N N 317 
SER N   H2   sing N N 318 
SER CA  C    sing N N 319 
SER CA  CB   sing N N 320 
SER CA  HA   sing N N 321 
SER C   O    doub N N 322 
SER C   OXT  sing N N 323 
SER CB  OG   sing N N 324 
SER CB  HB2  sing N N 325 
SER CB  HB3  sing N N 326 
SER OG  HG   sing N N 327 
SER OXT HXT  sing N N 328 
THR N   CA   sing N N 329 
THR N   H    sing N N 330 
THR N   H2   sing N N 331 
THR CA  C    sing N N 332 
THR CA  CB   sing N N 333 
THR CA  HA   sing N N 334 
THR C   O    doub N N 335 
THR C   OXT  sing N N 336 
THR CB  OG1  sing N N 337 
THR CB  CG2  sing N N 338 
THR CB  HB   sing N N 339 
THR OG1 HG1  sing N N 340 
THR CG2 HG21 sing N N 341 
THR CG2 HG22 sing N N 342 
THR CG2 HG23 sing N N 343 
THR OXT HXT  sing N N 344 
TRP N   CA   sing N N 345 
TRP N   H    sing N N 346 
TRP N   H2   sing N N 347 
TRP CA  C    sing N N 348 
TRP CA  CB   sing N N 349 
TRP CA  HA   sing N N 350 
TRP C   O    doub N N 351 
TRP C   OXT  sing N N 352 
TRP CB  CG   sing N N 353 
TRP CB  HB2  sing N N 354 
TRP CB  HB3  sing N N 355 
TRP CG  CD1  doub Y N 356 
TRP CG  CD2  sing Y N 357 
TRP CD1 NE1  sing Y N 358 
TRP CD1 HD1  sing N N 359 
TRP CD2 CE2  doub Y N 360 
TRP CD2 CE3  sing Y N 361 
TRP NE1 CE2  sing Y N 362 
TRP NE1 HE1  sing N N 363 
TRP CE2 CZ2  sing Y N 364 
TRP CE3 CZ3  doub Y N 365 
TRP CE3 HE3  sing N N 366 
TRP CZ2 CH2  doub Y N 367 
TRP CZ2 HZ2  sing N N 368 
TRP CZ3 CH2  sing Y N 369 
TRP CZ3 HZ3  sing N N 370 
TRP CH2 HH2  sing N N 371 
TRP OXT HXT  sing N N 372 
TYR N   CA   sing N N 373 
TYR N   H    sing N N 374 
TYR N   H2   sing N N 375 
TYR CA  C    sing N N 376 
TYR CA  CB   sing N N 377 
TYR CA  HA   sing N N 378 
TYR C   O    doub N N 379 
TYR C   OXT  sing N N 380 
TYR CB  CG   sing N N 381 
TYR CB  HB2  sing N N 382 
TYR CB  HB3  sing N N 383 
TYR CG  CD1  doub Y N 384 
TYR CG  CD2  sing Y N 385 
TYR CD1 CE1  sing Y N 386 
TYR CD1 HD1  sing N N 387 
TYR CD2 CE2  doub Y N 388 
TYR CD2 HD2  sing N N 389 
TYR CE1 CZ   doub Y N 390 
TYR CE1 HE1  sing N N 391 
TYR CE2 CZ   sing Y N 392 
TYR CE2 HE2  sing N N 393 
TYR CZ  OH   sing N N 394 
TYR OH  HH   sing N N 395 
TYR OXT HXT  sing N N 396 
VAL N   CA   sing N N 397 
VAL N   H    sing N N 398 
VAL N   H2   sing N N 399 
VAL CA  C    sing N N 400 
VAL CA  CB   sing N N 401 
VAL CA  HA   sing N N 402 
VAL C   O    doub N N 403 
VAL C   OXT  sing N N 404 
VAL CB  CG1  sing N N 405 
VAL CB  CG2  sing N N 406 
VAL CB  HB   sing N N 407 
VAL CG1 HG11 sing N N 408 
VAL CG1 HG12 sing N N 409 
VAL CG1 HG13 sing N N 410 
VAL CG2 HG21 sing N N 411 
VAL CG2 HG22 sing N N 412 
VAL CG2 HG23 sing N N 413 
VAL OXT HXT  sing N N 414 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
4 NAG 1 n 
4 NAG 2 n 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 6OBZ ? 
2 ? 'experimental model' PDB 6OCB ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9MEV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019747 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001202 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010699 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011591 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? -23.22500 -19.69500 27.66600  1.000 31.16158 ? 52  ALA B N   1 
ATOM   2    C CA  . ALA A 1 1   ? -23.02000 -18.41600 26.99600  1.000 25.85981 ? 52  ALA B CA  1 
ATOM   3    C C   . ALA A 1 1   ? -21.55400 -18.23200 26.61800  1.000 30.58092 ? 52  ALA B C   1 
ATOM   4    O O   . ALA A 1 1   ? -20.66300 -18.59900 27.38100  1.000 29.58363 ? 52  ALA B O   1 
ATOM   5    C CB  . ALA A 1 1   ? -23.49000 -17.27200 27.88000  1.000 26.78071 ? 52  ALA B CB  1 
ATOM   6    N N   . PRO A 1 2   ? -21.30600 -17.66400 25.44000  1.000 27.57847 ? 53  PRO B N   1 
ATOM   7    C CA  . PRO A 1 2   ? -19.92300 -17.51000 24.97500  1.000 25.73734 ? 53  PRO B CA  1 
ATOM   8    C C   . PRO A 1 2   ? -19.13200 -16.53800 25.83600  1.000 27.87062 ? 53  PRO B C   1 
ATOM   9    O O   . PRO A 1 2   ? -19.68100 -15.62400 26.45600  1.000 26.42406 ? 53  PRO B O   1 
ATOM   10   C CB  . PRO A 1 2   ? -20.08600 -16.97500 23.54600  1.000 26.85379 ? 53  PRO B CB  1 
ATOM   11   C CG  . PRO A 1 2   ? -21.49300 -17.32800 23.15800  1.000 31.92348 ? 53  PRO B CG  1 
ATOM   12   C CD  . PRO A 1 2   ? -22.27800 -17.22500 24.42600  1.000 26.94833 ? 53  PRO B CD  1 
ATOM   13   N N   . LEU A 1 3   ? -17.82000 -16.75400 25.86800  1.000 28.74266 ? 54  LEU B N   1 
ATOM   14   C CA  . LEU A 1 3   ? -16.88900 -15.86600 26.55200  1.000 20.72098 ? 54  LEU B CA  1 
ATOM   15   C C   . LEU A 1 3   ? -16.27000 -14.93100 25.52100  1.000 18.90975 ? 54  LEU B C   1 
ATOM   16   O O   . LEU A 1 3   ? -15.59200 -15.38600 24.59300  1.000 22.09937 ? 54  LEU B O   1 
ATOM   17   C CB  . LEU A 1 3   ? -15.80600 -16.66100 27.28200  1.000 25.16865 ? 54  LEU B CB  1 
ATOM   18   C CG  . LEU A 1 3   ? -14.67500 -15.84500 27.91300  1.000 30.13018 ? 54  LEU B CG  1 
ATOM   19   C CD1 . LEU A 1 3   ? -15.14600 -15.18400 29.20000  1.000 24.32228 ? 54  LEU B CD1 1 
ATOM   20   C CD2 . LEU A 1 3   ? -13.46200 -16.72400 28.17500  1.000 19.12166 ? 54  LEU B CD2 1 
ATOM   21   N N   . GLN A 1 4   ? -16.50800 -13.63100 25.68200  1.000 21.58543 ? 55  GLN B N   1 
ATOM   22   C CA  . GLN A 1 4   ? -16.04100 -12.62600 24.73200  1.000 24.78150 ? 55  GLN B CA  1 
ATOM   23   C C   . GLN A 1 4   ? -14.68300 -12.10300 25.18600  1.000 26.91235 ? 55  GLN B C   1 
ATOM   24   O O   . GLN A 1 4   ? -14.57700 -11.45700 26.23400  1.000 28.60237 ? 55  GLN B O   1 
ATOM   25   C CB  . GLN A 1 4   ? -17.05400 -11.49200 24.61500  1.000 24.55835 ? 55  GLN B CB  1 
ATOM   26   C CG  . GLN A 1 4   ? -18.48700 -11.95600 24.41200  1.000 33.05727 ? 55  GLN B CG  1 
ATOM   27   C CD  . GLN A 1 4   ? -18.72200 -12.51500 23.02200  1.000 31.56452 ? 55  GLN B CD  1 
ATOM   28   O OE1 . GLN A 1 4   ? -18.04100 -12.14000 22.06600  1.000 30.30470 ? 55  GLN B OE1 1 
ATOM   29   N NE2 . GLN A 1 4   ? -19.69200 -13.41300 22.90100  1.000 29.81807 ? 55  GLN B NE2 1 
ATOM   30   N N   . LEU A 1 5   ? -13.64500 -12.37700 24.39700  1.000 24.35014 ? 56  LEU B N   1 
ATOM   31   C CA  . LEU A 1 5   ? -12.29900 -11.90600 24.69700  1.000 22.17052 ? 56  LEU B CA  1 
ATOM   32   C C   . LEU A 1 5   ? -11.94900 -10.60500 23.98900  1.000 24.55393 ? 56  LEU B C   1 
ATOM   33   O O   . LEU A 1 5   ? -10.86200 -10.06600 24.21900  1.000 28.56879 ? 56  LEU B O   1 
ATOM   34   C CB  . LEU A 1 5   ? -11.26400 -12.97700 24.33700  1.000 19.54021 ? 56  LEU B CB  1 
ATOM   35   C CG  . LEU A 1 5   ? -11.27700 -14.26800 25.15600  1.000 26.60503 ? 56  LEU B CG  1 
ATOM   36   C CD1 . LEU A 1 5   ? -10.03700 -15.10000 24.85300  1.000 20.33931 ? 56  LEU B CD1 1 
ATOM   37   C CD2 . LEU A 1 5   ? -11.38900 -13.97500 26.64700  1.000 18.56950 ? 56  LEU B CD2 1 
ATOM   38   N N   . GLY A 1 6   ? -12.82900 -10.10000 23.13200  1.000 28.05207 ? 57  GLY B N   1 
ATOM   39   C CA  . GLY A 1 6   ? -12.59000 -8.82000  22.48700  1.000 29.63538 ? 57  GLY B CA  1 
ATOM   40   C C   . GLY A 1 6   ? -11.37800 -8.87000  21.57800  1.000 31.41997 ? 57  GLY B C   1 
ATOM   41   O O   . GLY A 1 6   ? -11.32800 -9.63900  20.60900  1.000 32.54425 ? 57  GLY B O   1 
ATOM   42   N N   . ASN A 1 7   ? -10.38200 -8.06400  21.91300  1.000 27.54328 ? 58  ASN B N   1 
ATOM   43   C CA  . ASN A 1 7   ? -9.18300  -7.97600  21.11300  1.000 30.17106 ? 58  ASN B CA  1 
ATOM   44   C C   . ASN A 1 7   ? -8.05200  -8.81400  21.67700  1.000 30.85255 ? 58  ASN B C   1 
ATOM   45   O O   . ASN A 1 7   ? -6.91800  -8.67600  21.26400  1.000 31.86796 ? 58  ASN B O   1 
ATOM   46   C CB  . ASN A 1 7   ? -8.74300  -6.50900  21.00300  1.000 37.77346 ? 58  ASN B CB  1 
ATOM   47   C CG  . ASN A 1 7   ? -9.71100  -5.65100  20.20800  1.000 44.63207 ? 58  ASN B CG  1 
ATOM   48   O OD1 . ASN A 1 7   ? -10.20600 -6.05900  19.16600  1.000 41.73208 ? 58  ASN B OD1 1 
ATOM   49   N ND2 . ASN A 1 7   ? -9.97300  -4.44400  20.70500  1.000 58.42812 ? 58  ASN B ND2 1 
ATOM   50   N N   . CYS A 1 8   ? -8.37100  -9.69300  22.59600  1.000 25.07404 ? 59  CYS B N   1 
ATOM   51   C CA  . CYS A 1 8   ? -7.36200  -10.50400 23.22100  1.000 21.34079 ? 59  CYS B CA  1 
ATOM   52   C C   . CYS A 1 8   ? -7.39900  -11.97300 22.86400  1.000 30.72431 ? 59  CYS B C   1 
ATOM   53   O O   . CYS A 1 8   ? -8.43900  -12.49700 22.52300  1.000 30.37251 ? 59  CYS B O   1 
ATOM   54   C CB  . CYS A 1 8   ? -7.47100  -10.37500 24.73400  1.000 20.37124 ? 59  CYS B CB  1 
ATOM   55   S SG  . CYS A 1 8   ? -7.20800  -8.75400  25.44400  1.000 32.47005 ? 59  CYS B SG  1 
ATOM   56   N N   . SER A 1 9   ? -6.25400  -12.62100 22.92700  1.000 25.56613 ? 60  SER B N   1 
ATOM   57   C CA  . SER A 1 9   ? -6.16500  -14.04200 22.70300  1.000 25.69900 ? 60  SER B CA  1 
ATOM   58   C C   . SER A 1 9   ? -6.37400  -14.76100 24.02100  1.000 22.03470 ? 60  SER B C   1 
ATOM   59   O O   . SER A 1 9   ? -6.35500  -14.13200 25.05900  1.000 19.19492 ? 60  SER B O   1 
ATOM   60   C CB  . SER A 1 9   ? -4.76700  -14.38500 22.20100  1.000 22.63186 ? 60  SER B CB  1 
ATOM   61   O OG  . SER A 1 9   ? -3.79700  -14.30900 23.21800  1.000 24.99139 ? 60  SER B OG  1 
ATOM   62   N N   . VAL A 1 10  ? -6.54200  -16.06500 23.97900  1.000 20.01143 ? 61  VAL B N   1 
ATOM   63   C CA  . VAL A 1 10  ? -6.61500  -16.84200 25.21300  1.000 21.57137 ? 61  VAL B CA  1 
ATOM   64   C C   . VAL A 1 10  ? -5.36000  -16.62300 26.04600  1.000 19.45014 ? 61  VAL B C   1 
ATOM   65   O O   . VAL A 1 10  ? -5.42800  -16.47400 27.27200  1.000 19.64024 ? 61  VAL B O   1 
ATOM   66   C CB  . VAL A 1 10  ? -6.83400  -18.33500 24.89800  1.000 23.35953 ? 61  VAL B CB  1 
ATOM   67   C CG1 . VAL A 1 10  ? -6.68300  -19.17600 26.15600  1.000 22.50755 ? 61  VAL B CG1 1 
ATOM   68   C CG2 . VAL A 1 10  ? -8.20200  -18.54900 24.27300  1.000 23.89114 ? 61  VAL B CG2 1 
ATOM   69   N N   . ALA A 1 11  ? -4.21200  -16.60000 25.40700  1.000 17.59466 ? 62  ALA B N   1 
ATOM   70   C CA  . ALA A 1 11  ? -2.95800  -16.34500 26.11600  1.000 21.15519 ? 62  ALA B CA  1 
ATOM   71   C C   . ALA A 1 11  ? -2.91600  -14.98500 26.82200  1.000 17.57833 ? 62  ALA B C   1 
ATOM   72   O O   . ALA A 1 11  ? -2.55400  -14.91300 27.96100  1.000 18.37446 ? 62  ALA B O   1 
ATOM   73   C CB  . ALA A 1 11  ? -1.79000  -16.50900 25.16400  1.000 20.60548 ? 62  ALA B CB  1 
ATOM   74   N N   . GLY A 1 12  ? -3.29800  -13.92800 26.11900  1.000 20.12723 ? 63  GLY B N   1 
ATOM   75   C CA  . GLY A 1 12  ? -3.33400  -12.59900 26.69800  1.000 19.94475 ? 63  GLY B CA  1 
ATOM   76   C C   . GLY A 1 12  ? -4.27600  -12.50800 27.87000  1.000 21.15086 ? 63  GLY B C   1 
ATOM   77   O O   . GLY A 1 12  ? -3.96900  -11.88200 28.84600  1.000 19.58958 ? 63  GLY B O   1 
ATOM   78   N N   . TRP A 1 13  ? -5.42500  -13.14800 27.75100  1.000 23.39251 ? 64  TRP B N   1 
ATOM   79   C CA  . TRP A 1 13  ? -6.38200  -13.20800 28.84400  1.000 17.97159 ? 64  TRP B CA  1 
ATOM   80   C C   . TRP A 1 13  ? -5.87100  -14.03100 30.00900  1.000 22.05121 ? 64  TRP B C   1 
ATOM   81   O O   . TRP A 1 13  ? -5.82400  -13.53200 31.10500  1.000 27.48368 ? 64  TRP B O   1 
ATOM   82   C CB  . TRP A 1 13  ? -7.70500  -13.76800 28.32300  1.000 16.09331 ? 64  TRP B CB  1 
ATOM   83   C CG  . TRP A 1 13  ? -8.65000  -14.27100 29.34900  1.000 22.23590 ? 64  TRP B CG  1 
ATOM   84   C CD1 . TRP A 1 13  ? -9.26300  -13.54900 30.31600  1.000 25.86445 ? 64  TRP B CD1 1 
ATOM   85   C CD2 . TRP A 1 13  ? -9.12400  -15.60900 29.48500  1.000 20.38951 ? 64  TRP B CD2 1 
ATOM   86   N NE1 . TRP A 1 13  ? -10.07600 -14.35400 31.06600  1.000 29.79058 ? 64  TRP B NE1 1 
ATOM   87   C CE2 . TRP A 1 13  ? -10.01100 -15.62700 30.57200  1.000 24.13342 ? 64  TRP B CE2 1 
ATOM   88   C CE3 . TRP A 1 13  ? -8.87800  -16.79700 28.80100  1.000 21.83281 ? 64  TRP B CE3 1 
ATOM   89   C CZ2 . TRP A 1 13  ? -10.65100 -16.78000 30.98700  1.000 22.90224 ? 64  TRP B CZ2 1 
ATOM   90   C CZ3 . TRP A 1 13  ? -9.51000  -17.93700 29.21700  1.000 23.63386 ? 64  TRP B CZ3 1 
ATOM   91   C CH2 . TRP A 1 13  ? -10.38500 -17.92300 30.29900  1.000 23.18209 ? 64  TRP B CH2 1 
ATOM   92   N N   . ILE A 1 14  ? -5.46100  -15.26700 29.77200  1.000 18.54707 ? 65  ILE B N   1 
ATOM   93   C CA  . ILE A 1 14  ? -5.02800  -16.15800 30.84300  1.000 20.98216 ? 65  ILE B CA  1 
ATOM   94   C C   . ILE A 1 14  ? -3.76800  -15.67900 31.58300  1.000 22.25136 ? 65  ILE B C   1 
ATOM   95   O O   . ILE A 1 14  ? -3.66400  -15.86300 32.77200  1.000 23.58443 ? 65  ILE B O   1 
ATOM   96   C CB  . ILE A 1 14  ? -4.83000  -17.62600 30.34900  1.000 20.70131 ? 65  ILE B CB  1 
ATOM   97   C CG1 . ILE A 1 14  ? -5.08300  -18.59100 31.50300  1.000 30.88289 ? 65  ILE B CG1 1 
ATOM   98   C CG2 . ILE A 1 14  ? -3.46100  -17.82300 29.72800  1.000 18.74384 ? 65  ILE B CG2 1 
ATOM   99   C CD1 . ILE A 1 14  ? -6.40600  -18.36000 32.19700  1.000 26.79140 ? 65  ILE B CD1 1 
ATOM   100  N N   . LEU A 1 15  ? -2.84300  -15.07500 30.87000  1.000 18.55045 ? 66  LEU B N   1 
ATOM   101  C CA  . LEU A 1 15  ? -1.62200  -14.58100 31.48300  1.000 21.79728 ? 66  LEU B CA  1 
ATOM   102  C C   . LEU A 1 15  ? -1.82900  -13.20700 32.11900  1.000 24.18881 ? 66  LEU B C   1 
ATOM   103  O O   . LEU A 1 15  ? -1.11000  -12.81400 33.01200  1.000 22.74151 ? 66  LEU B O   1 
ATOM   104  C CB  . LEU A 1 15  ? -0.51100  -14.53500 30.44200  1.000 17.40046 ? 66  LEU B CB  1 
ATOM   105  C CG  . LEU A 1 15  ? -0.03600  -15.83400 29.80800  1.000 21.79948 ? 66  LEU B CG  1 
ATOM   106  C CD1 . LEU A 1 15  ? 0.96400   -15.53900 28.70500  1.000 14.37652 ? 66  LEU B CD1 1 
ATOM   107  C CD2 . LEU A 1 15  ? 0.56500   -16.74600 30.86000  1.000 21.10132 ? 66  LEU B CD2 1 
ATOM   108  N N   . GLY A 1 16  ? -2.82800  -12.49300 31.64600  1.000 23.94371 ? 67  GLY B N   1 
ATOM   109  C CA  . GLY A 1 16  ? -3.07100  -11.16400 32.14100  1.000 21.54258 ? 67  GLY B CA  1 
ATOM   110  C C   . GLY A 1 16  ? -2.40000  -10.03200 31.42400  1.000 24.55341 ? 67  GLY B C   1 
ATOM   111  O O   . GLY A 1 16  ? -1.92300  -9.13100  32.06400  1.000 26.22541 ? 67  GLY B O   1 
ATOM   112  N N   . ASN A 1 17  ? -2.32100  -10.09000 30.11400  1.000 19.93687 ? 68  ASN B N   1 
ATOM   113  C CA  . ASN A 1 17  ? -1.80800  -8.99400  29.34600  1.000 23.26827 ? 68  ASN B CA  1 
ATOM   114  C C   . ASN A 1 17  ? -2.49800  -7.75900  29.85900  1.000 26.87126 ? 68  ASN B C   1 
ATOM   115  O O   . ASN A 1 17  ? -3.70700  -7.70300  29.90300  1.000 30.56493 ? 68  ASN B O   1 
ATOM   116  C CB  . ASN A 1 17  ? -2.11000  -9.20200  27.86400  1.000 22.92788 ? 68  ASN B CB  1 
ATOM   117  C CG  . ASN A 1 17  ? -1.66200  -8.05000  26.98000  1.000 24.64661 ? 68  ASN B CG  1 
ATOM   118  O OD1 . ASN A 1 17  ? -1.88100  -6.88800  27.28000  1.000 22.43792 ? 68  ASN B OD1 1 
ATOM   119  N ND2 . ASN A 1 17  ? -1.07300  -8.38900  25.84700  1.000 21.76658 ? 68  ASN B ND2 1 
ATOM   120  N N   . PRO A 1 18  ? -1.72600  -6.74800  30.21600  1.000 36.45309 ? 69  PRO B N   1 
ATOM   121  C CA  . PRO A 1 18  ? -2.28500  -5.52700  30.78600  1.000 30.23939 ? 69  PRO B CA  1 
ATOM   122  C C   . PRO A 1 18  ? -3.43400  -4.89400  29.97300  1.000 32.74655 ? 69  PRO B C   1 
ATOM   123  O O   . PRO A 1 18  ? -4.29000  -4.30600  30.58500  1.000 36.02753 ? 69  PRO B O   1 
ATOM   124  C CB  . PRO A 1 18  ? -1.07300  -4.60000  30.82600  1.000 34.34525 ? 69  PRO B CB  1 
ATOM   125  C CG  . PRO A 1 18  ? -0.01900  -5.23500  29.99300  1.000 34.00912 ? 69  PRO B CG  1 
ATOM   126  C CD  . PRO A 1 18  ? -0.26500  -6.69200  30.11700  1.000 27.68900 ? 69  PRO B CD  1 
ATOM   127  N N   . GLU A 1 19  ? -3.45200  -5.02600  28.65700  1.000 28.70532 ? 70  GLU B N   1 
ATOM   128  C CA  . GLU A 1 19  ? -4.53000  -4.50000  27.81800  1.000 26.38568 ? 70  GLU B CA  1 
ATOM   129  C C   . GLU A 1 19  ? -5.78800  -5.36800  27.83000  1.000 34.42182 ? 70  GLU B C   1 
ATOM   130  O O   . GLU A 1 19  ? -6.77900  -5.01700  27.22900  1.000 34.25560 ? 70  GLU B O   1 
ATOM   131  C CB  . GLU A 1 19  ? -4.03300  -4.33300  26.39300  1.000 27.19670 ? 70  GLU B CB  1 
ATOM   132  C CG  . GLU A 1 19  ? -2.83100  -3.42200  26.24400  1.000 35.26102 ? 70  GLU B CG  1 
ATOM   133  C CD  . GLU A 1 19  ? -3.14700  -1.98100  26.58500  1.000 46.04406 ? 70  GLU B CD  1 
ATOM   134  O OE1 . GLU A 1 19  ? -3.21600  -1.65300  27.77900  1.000 39.56148 ? 70  GLU B OE1 1 
ATOM   135  O OE2 . GLU A 1 19  ? -3.32000  -1.17600  25.65400  1.000 49.73193 ? 70  GLU B OE2 1 
ATOM   136  N N   . CYS A 1 20  ? -5.73200  -6.50000  28.49600  1.000 29.38546 ? 71  CYS B N   1 
ATOM   137  C CA  . CYS A 1 20  ? -6.84900  -7.41300  28.55600  1.000 33.43075 ? 71  CYS B CA  1 
ATOM   138  C C   . CYS A 1 20  ? -7.53400  -7.32700  29.91800  1.000 40.50866 ? 71  CYS B C   1 
ATOM   139  O O   . CYS A 1 20  ? -8.16700  -8.27600  30.35600  1.000 41.10334 ? 71  CYS B O   1 
ATOM   140  C CB  . CYS A 1 20  ? -6.35100  -8.82600  28.26100  1.000 26.73572 ? 71  CYS B CB  1 
ATOM   141  S SG  . CYS A 1 20  ? -5.62000  -9.04000  26.65000  1.000 29.01193 ? 71  CYS B SG  1 
ATOM   142  N N   . GLU A 1 21  ? -7.43100  -6.18100  30.56800  1.000 34.95182 ? 72  GLU B N   1 
ATOM   143  C CA  . GLU A 1 21  ? -7.97300  -6.00600  31.89800  1.000 39.24469 ? 72  GLU B CA  1 
ATOM   144  C C   . GLU A 1 21  ? -9.44000  -5.66900  32.01700  1.000 43.91109 ? 72  GLU B C   1 
ATOM   145  O O   . GLU A 1 21  ? -10.02900 -5.97900  33.03100  1.000 51.66199 ? 72  GLU B O   1 
ATOM   146  C CB  . GLU A 1 21  ? -7.21500  -4.86800  32.57300  1.000 56.80168 ? 72  GLU B CB  1 
ATOM   147  C CG  . GLU A 1 21  ? -7.38700  -3.52000  31.89000  1.000 57.37815 ? 72  GLU B CG  1 
ATOM   148  C CD  . GLU A 1 21  ? -6.98000  -2.34100  32.75800  1.000 70.12999 ? 72  GLU B CD  1 
ATOM   149  O OE1 . GLU A 1 21  ? -6.46500  -2.55500  33.87500  1.000 68.57581 ? 72  GLU B OE1 1 
ATOM   150  O OE2 . GLU A 1 21  ? -7.18000  -1.18900  32.32000  1.000 63.49024 ? 72  GLU B OE2 1 
ATOM   151  N N   . LEU A 1 22  ? -10.02600 -5.01600  31.02800  1.000 43.73182 ? 73  LEU B N   1 
ATOM   152  C CA  . LEU A 1 22  ? -11.41600 -4.59100  31.18000  1.000 56.14711 ? 73  LEU B CA  1 
ATOM   153  C C   . LEU A 1 22  ? -12.36000 -5.74600  30.89200  1.000 52.18225 ? 73  LEU B C   1 
ATOM   154  O O   . LEU A 1 22  ? -13.56200 -5.62900  31.02800  1.000 55.90548 ? 73  LEU B O   1 
ATOM   155  C CB  . LEU A 1 22  ? -11.73100 -3.36900  30.33200  1.000 44.88260 ? 73  LEU B CB  1 
ATOM   156  C CG  . LEU A 1 22  ? -10.87800 -2.13900  30.60100  1.000 56.86071 ? 73  LEU B CG  1 
ATOM   157  C CD1 . LEU A 1 22  ? -11.30100 -0.99200  29.69700  1.000 54.87934 ? 73  LEU B CD1 1 
ATOM   158  C CD2 . LEU A 1 22  ? -10.97800 -1.74600  32.06200  1.000 60.18829 ? 73  LEU B CD2 1 
ATOM   159  N N   . LEU A 1 23  ? -11.81100 -6.86400  30.49900  1.000 53.93355 ? 74  LEU B N   1 
ATOM   160  C CA  . LEU A 1 23  ? -12.64800 -8.01900  30.24300  1.000 54.54287 ? 74  LEU B CA  1 
ATOM   161  C C   . LEU A 1 23  ? -13.51700 -8.22900  31.46400  1.000 53.46598 ? 74  LEU B C   1 
ATOM   162  O O   . LEU A 1 23  ? -13.03800 -8.24300  32.57900  1.000 51.45175 ? 74  LEU B O   1 
ATOM   163  C CB  . LEU A 1 23  ? -11.83000 -9.26000  29.87700  1.000 52.51353 ? 74  LEU B CB  1 
ATOM   164  C CG  . LEU A 1 23  ? -11.17000 -9.36700  28.51100  1.000 46.14927 ? 74  LEU B CG  1 
ATOM   165  C CD1 . LEU A 1 23  ? -10.51200 -10.72600 28.39500  1.000 40.01703 ? 74  LEU B CD1 1 
ATOM   166  C CD2 . LEU A 1 23  ? -12.18900 -9.17400  27.40100  1.000 42.25234 ? 74  LEU B CD2 1 
ATOM   167  N N   . ILE A 1 24  ? -14.78900 -8.36600  31.26200  1.000 59.01237 ? 75  ILE B N   1 
ATOM   168  C CA  . ILE A 1 24  ? -15.74800 -8.49000  32.35400  1.000 58.74596 ? 75  ILE B CA  1 
ATOM   169  C C   . ILE A 1 24  ? -15.68000 -9.85300  33.02600  1.000 50.26369 ? 75  ILE B C   1 
ATOM   170  O O   . ILE A 1 24  ? -15.40900 -10.84300 32.36500  1.000 51.62156 ? 75  ILE B O   1 
ATOM   171  C CB  . ILE A 1 24  ? -17.17500 -8.21700  31.81600  1.000 60.56127 ? 75  ILE B CB  1 
ATOM   172  C CG1 . ILE A 1 24  ? -17.20200 -6.91700  31.01600  1.000 55.77563 ? 75  ILE B CG1 1 
ATOM   173  C CG2 . ILE A 1 24  ? -18.18300 -8.17100  32.95300  1.000 61.28260 ? 75  ILE B CG2 1 
ATOM   174  C CD1 . ILE A 1 24  ? -16.73400 -5.71100  31.80200  1.000 67.99782 ? 75  ILE B CD1 1 
ATOM   175  N N   . SER A 1 25  ? -15.94600 -9.91800  34.32000  1.000 39.92044 ? 76  SER B N   1 
ATOM   176  C CA  . SER A 1 25  ? -15.80700 -11.18400 35.01800  1.000 44.55128 ? 76  SER B CA  1 
ATOM   177  C C   . SER A 1 25  ? -16.87700 -12.20000 34.64600  1.000 42.37907 ? 76  SER B C   1 
ATOM   178  O O   . SER A 1 25  ? -18.01800 -11.83900 34.41700  1.000 46.01011 ? 76  SER B O   1 
ATOM   179  C CB  . SER A 1 25  ? -15.76600 -10.98800 36.53700  1.000 45.46839 ? 76  SER B CB  1 
ATOM   180  O OG  . SER A 1 25  ? -15.36300 -12.16300 37.20300  1.000 49.28669 ? 76  SER B OG  1 
ATOM   181  N N   . ARG A 1 26  ? -16.48600 -13.45600 34.56100  1.000 34.19761 ? 77  ARG B N   1 
ATOM   182  C CA  . ARG A 1 26  ? -17.41000 -14.50800 34.25100  1.000 35.96799 ? 77  ARG B CA  1 
ATOM   183  C C   . ARG A 1 26  ? -17.04200 -15.70900 35.07400  1.000 43.70593 ? 77  ARG B C   1 
ATOM   184  O O   . ARG A 1 26  ? -15.87700 -16.04400 35.19700  1.000 40.38963 ? 77  ARG B O   1 
ATOM   185  C CB  . ARG A 1 26  ? -17.36600 -14.86300 32.77300  1.000 32.24713 ? 77  ARG B CB  1 
ATOM   186  C CG  . ARG A 1 26  ? -17.86700 -13.78200 31.84100  1.000 30.52330 ? 77  ARG B CG  1 
ATOM   187  C CD  . ARG A 1 26  ? -19.38000 -13.76000 31.79400  1.000 29.13660 ? 77  ARG B CD  1 
ATOM   188  N NE  . ARG A 1 26  ? -19.93500 -15.04800 31.41000  1.000 26.23045 ? 77  ARG B NE  1 
ATOM   189  C CZ  . ARG A 1 26  ? -19.98900 -15.48700 30.16100  1.000 31.52576 ? 77  ARG B CZ  1 
ATOM   190  N NH1 . ARG A 1 26  ? -19.50600 -14.74800 29.18000  1.000 24.92996 ? 77  ARG B NH1 1 
ATOM   191  N NH2 . ARG A 1 26  ? -20.51600 -16.67000 29.89500  1.000 30.50506 ? 77  ARG B NH2 1 
ATOM   192  N N   . GLU A 1 27  ? -18.03400 -16.37600 35.62600  1.000 37.09748 ? 78  GLU B N   1 
ATOM   193  C CA  . GLU A 1 27  ? -17.79200 -17.58700 36.37400  1.000 36.10018 ? 78  GLU B CA  1 
ATOM   194  C C   . GLU A 1 27  ? -18.06500 -18.82600 35.56000  1.000 32.23688 ? 78  GLU B C   1 
ATOM   195  O O   . GLU A 1 27  ? -17.69800 -19.91000 35.94800  1.000 38.64595 ? 78  GLU B O   1 
ATOM   196  C CB  . GLU A 1 27  ? -18.66700 -17.59300 37.61400  1.000 44.75928 ? 78  GLU B CB  1 
ATOM   197  C CG  . GLU A 1 27  ? -18.24700 -16.55000 38.63700  1.000 55.70070 ? 78  GLU B CG  1 
ATOM   198  C CD  . GLU A 1 27  ? -18.98900 -16.67500 39.95200  1.000 74.66092 ? 78  GLU B CD  1 
ATOM   199  O OE1 . GLU A 1 27  ? -19.42900 -17.79200 40.28800  1.000 73.22820 ? 78  GLU B OE1 1 
ATOM   200  O OE2 . GLU A 1 27  ? -19.13400 -15.65100 40.64900  1.000 78.06629 ? 78  GLU B OE2 1 
ATOM   201  N N   . SER A 1 28  ? -18.72800 -18.65700 34.43500  1.000 37.22323 ? 79  SER B N   1 
ATOM   202  C CA  . SER A 1 28  ? -19.04400 -19.77600 33.56800  1.000 34.95211 ? 79  SER B CA  1 
ATOM   203  C C   . SER A 1 28  ? -19.13400 -19.35100 32.13900  1.000 29.25423 ? 79  SER B C   1 
ATOM   204  O O   . SER A 1 28  ? -19.40600 -18.20900 31.85800  1.000 30.58914 ? 79  SER B O   1 
ATOM   205  C CB  . SER A 1 28  ? -20.37900 -20.43000 33.95100  1.000 29.99794 ? 79  SER B CB  1 
ATOM   206  O OG  . SER A 1 28  ? -21.48000 -19.73400 33.42100  1.000 36.32240 ? 79  SER B OG  1 
ATOM   207  N N   . TRP A 1 29  ? -18.88100 -20.28300 31.24600  1.000 29.59247 ? 80  TRP B N   1 
ATOM   208  C CA  . TRP A 1 29  ? -19.01300 -20.02500 29.82800  1.000 31.01375 ? 80  TRP B CA  1 
ATOM   209  C C   . TRP A 1 29  ? -18.87100 -21.29100 28.99000  1.000 28.95826 ? 80  TRP B C   1 
ATOM   210  O O   . TRP A 1 29  ? -18.40000 -22.29800 29.46000  1.000 28.83282 ? 80  TRP B O   1 
ATOM   211  C CB  . TRP A 1 29  ? -17.99700 -18.99000 29.33600  1.000 26.56600 ? 80  TRP B CB  1 
ATOM   212  C CG  . TRP A 1 29  ? -16.59700 -19.44700 29.44300  1.000 33.00022 ? 80  TRP B CG  1 
ATOM   213  C CD1 . TRP A 1 29  ? -15.92400 -20.23800 28.56900  1.000 33.40800 ? 80  TRP B CD1 1 
ATOM   214  C CD2 . TRP A 1 29  ? -15.68800 -19.14300 30.49300  1.000 23.75686 ? 80  TRP B CD2 1 
ATOM   215  N NE1 . TRP A 1 29  ? -14.64900 -20.44900 29.00800  1.000 28.45825 ? 80  TRP B NE1 1 
ATOM   216  C CE2 . TRP A 1 29  ? -14.47700 -19.78600 30.19300  1.000 34.69253 ? 80  TRP B CE2 1 
ATOM   217  C CE3 . TRP A 1 29  ? -15.77900 -18.39100 31.66100  1.000 25.79273 ? 80  TRP B CE3 1 
ATOM   218  C CZ2 . TRP A 1 29  ? -13.36800 -19.69600 31.01400  1.000 30.50383 ? 80  TRP B CZ2 1 
ATOM   219  C CZ3 . TRP A 1 29  ? -14.67600 -18.30400 32.47400  1.000 37.54321 ? 80  TRP B CZ3 1 
ATOM   220  C CH2 . TRP A 1 29  ? -13.48700 -18.95200 32.14900  1.000 28.92172 ? 80  TRP B CH2 1 
ATOM   221  N N   . SER A 1 30  ? -19.30800 -21.21900 27.75300  1.000 31.18636 ? 81  SER B N   1 
ATOM   222  C CA  . SER A 1 30  ? -19.12900 -22.31900 26.82500  1.000 41.80603 ? 81  SER B CA  1 
ATOM   223  C C   . SER A 1 30  ? -18.80900 -21.62300 25.52100  1.000 39.19540 ? 81  SER B C   1 
ATOM   224  O O   . SER A 1 30  ? -19.54900 -20.75200 25.10800  1.000 39.77410 ? 81  SER B O   1 
ATOM   225  C CB  . SER A 1 30  ? -20.34800 -23.23300 26.72600  1.000 45.44352 ? 81  SER B CB  1 
ATOM   226  O OG  . SER A 1 30  ? -20.65700 -23.82100 27.97600  1.000 54.97553 ? 81  SER B OG  1 
ATOM   227  N N   . TYR A 1 31  ? -17.71500 -21.98500 24.89000  1.000 32.86911 ? 82  TYR B N   1 
ATOM   228  C CA  . TYR A 1 31  ? -17.23800 -21.31600 23.67300  1.000 29.25717 ? 82  TYR B CA  1 
ATOM   229  C C   . TYR A 1 31  ? -16.54700 -19.98000 23.94300  1.000 28.47620 ? 82  TYR B C   1 
ATOM   230  O O   . TYR A 1 31  ? -17.10100 -19.09900 24.56000  1.000 29.66323 ? 82  TYR B O   1 
ATOM   231  C CB  . TYR A 1 31  ? -18.30400 -21.11800 22.61100  1.000 28.06990 ? 82  TYR B CB  1 
ATOM   232  C CG  . TYR A 1 31  ? -17.73300 -20.71300 21.28100  1.000 28.02506 ? 82  TYR B CG  1 
ATOM   233  C CD1 . TYR A 1 31  ? -17.17800 -21.65200 20.42800  1.000 23.82325 ? 82  TYR B CD1 1 
ATOM   234  C CD2 . TYR A 1 31  ? -17.74100 -19.39000 20.88000  1.000 32.22558 ? 82  TYR B CD2 1 
ATOM   235  C CE1 . TYR A 1 31  ? -16.65600 -21.28300 19.20800  1.000 26.58327 ? 82  TYR B CE1 1 
ATOM   236  C CE2 . TYR A 1 31  ? -17.22400 -19.01400 19.66400  1.000 29.32109 ? 82  TYR B CE2 1 
ATOM   237  C CZ  . TYR A 1 31  ? -16.68100 -19.96100 18.83500  1.000 26.53075 ? 82  TYR B CZ  1 
ATOM   238  O OH  . TYR A 1 31  ? -16.16600 -19.56900 17.63100  1.000 29.61735 ? 82  TYR B OH  1 
ATOM   239  N N   . ILE A 1 32  ? -15.35000 -19.84100 23.41800  1.000 26.58409 ? 83  ILE B N   1 
ATOM   240  C CA  . ILE A 1 32  ? -14.61500 -18.61900 23.58300  1.000 25.07031 ? 83  ILE B CA  1 
ATOM   241  C C   . ILE A 1 32  ? -14.53900 -17.87800 22.28200  1.000 21.51818 ? 83  ILE B C   1 
ATOM   242  O O   . ILE A 1 32  ? -14.13400 -18.42200 21.28300  1.000 28.23877 ? 83  ILE B O   1 
ATOM   243  C CB  . ILE A 1 32  ? -13.20100 -18.89100 24.11500  1.000 28.36217 ? 83  ILE B CB  1 
ATOM   244  C CG1 . ILE A 1 32  ? -13.28700 -19.53900 25.49800  1.000 29.54602 ? 83  ILE B CG1 1 
ATOM   245  C CG2 . ILE A 1 32  ? -12.39700 -17.60600 24.15400  1.000 18.44132 ? 83  ILE B CG2 1 
ATOM   246  C CD1 . ILE A 1 32  ? -11.95800 -19.94100 26.08200  1.000 28.16324 ? 83  ILE B CD1 1 
ATOM   247  N N   . VAL A 1 33  ? -14.92500 -16.63200 22.30200  1.000 26.63055 ? 84  VAL B N   1 
ATOM   248  C CA  . VAL A 1 33  ? -14.95000 -15.83500 21.09300  1.000 26.43026 ? 84  VAL B CA  1 
ATOM   249  C C   . VAL A 1 33  ? -13.63200 -15.08700 20.94600  1.000 31.28511 ? 84  VAL B C   1 
ATOM   250  O O   . VAL A 1 33  ? -13.36100 -14.15800 21.68500  1.000 29.16323 ? 84  VAL B O   1 
ATOM   251  C CB  . VAL A 1 33  ? -16.16400 -14.90200 21.05500  1.000 28.81270 ? 84  VAL B CB  1 
ATOM   252  C CG1 . VAL A 1 33  ? -16.24600 -14.20500 19.71100  1.000 27.83990 ? 84  VAL B CG1 1 
ATOM   253  C CG2 . VAL A 1 33  ? -17.43600 -15.67900 21.33100  1.000 27.74917 ? 84  VAL B CG2 1 
ATOM   254  N N   . GLU A 1 34  ? -12.82100 -15.52500 20.00600  1.000 23.32095 ? 85  GLU B N   1 
ATOM   255  C CA  . GLU A 1 34  ? -11.50400 -14.94600 19.79500  1.000 28.75828 ? 85  GLU B CA  1 
ATOM   256  C C   . GLU A 1 34  ? -11.36800 -14.54000 18.33500  1.000 31.51546 ? 85  GLU B C   1 
ATOM   257  O O   . GLU A 1 34  ? -11.75600 -15.29300 17.43700  1.000 35.81409 ? 85  GLU B O   1 
ATOM   258  C CB  . GLU A 1 34  ? -10.40100 -15.94400 20.17600  1.000 28.00384 ? 85  GLU B CB  1 
ATOM   259  C CG  . GLU A 1 34  ? -8.99100  -15.40000 20.06000  1.000 38.24803 ? 85  GLU B CG  1 
ATOM   260  C CD  . GLU A 1 34  ? -7.94600  -16.39300 20.53200  1.000 33.47960 ? 85  GLU B CD  1 
ATOM   261  O OE1 . GLU A 1 34  ? -8.31100  -17.34200 21.25400  1.000 34.03066 ? 85  GLU B OE1 1 
ATOM   262  O OE2 . GLU A 1 34  ? -6.76000  -16.23000 20.17700  1.000 42.92967 ? 85  GLU B OE2 1 
ATOM   263  N N   . LYS A 1 35  ? -10.82200 -13.34500 18.10300  1.000 27.40215 ? 86  LYS B N   1 
ATOM   264  C CA  . LYS A 1 35  ? -10.59600 -12.87900 16.74500  1.000 33.88975 ? 86  LYS B CA  1 
ATOM   265  C C   . LYS A 1 35  ? -9.58600  -13.78300 16.03700  1.000 32.33894 ? 86  LYS B C   1 
ATOM   266  O O   . LYS A 1 35  ? -8.80600  -14.48500 16.68500  1.000 39.49811 ? 86  LYS B O   1 
ATOM   267  C CB  . LYS A 1 35  ? -10.09900 -11.43300 16.74900  1.000 38.26029 ? 86  LYS B CB  1 
ATOM   268  C CG  . LYS A 1 35  ? -11.11000 -10.42100 17.26400  1.000 42.64486 ? 86  LYS B CG  1 
ATOM   269  C CD  . LYS A 1 35  ? -10.50200 -9.03100  17.34600  1.000 38.89949 ? 86  LYS B CD  1 
ATOM   270  C CE  . LYS A 1 35  ? -11.07600 -8.11700  16.27600  1.000 54.79012 ? 86  LYS B CE  1 
ATOM   271  N NZ  . LYS A 1 35  ? -12.25200 -7.34600  16.76900  1.000 60.50162 ? 86  LYS B NZ  1 
ATOM   272  N N   . PRO A 1 36  ? -9.59800  -13.79700 14.70000  1.000 35.35862 ? 87  PRO B N   1 
ATOM   273  C CA  . PRO A 1 36  ? -8.60600  -14.61500 13.97800  1.000 37.17430 ? 87  PRO B CA  1 
ATOM   274  C C   . PRO A 1 36  ? -7.16900  -14.21600 14.27100  1.000 42.81132 ? 87  PRO B C   1 
ATOM   275  O O   . PRO A 1 36  ? -6.29900  -15.09100 14.36700  1.000 42.07600 ? 87  PRO B O   1 
ATOM   276  C CB  . PRO A 1 36  ? -8.97500  -14.39600 12.50100  1.000 34.93350 ? 87  PRO B CB  1 
ATOM   277  C CG  . PRO A 1 36  ? -9.87900  -13.19700 12.48200  1.000 42.97091 ? 87  PRO B CG  1 
ATOM   278  C CD  . PRO A 1 36  ? -10.59400 -13.20500 13.79100  1.000 42.02416 ? 87  PRO B CD  1 
ATOM   279  N N   . ASN A 1 37  ? -6.91500  -12.91900 14.41800  1.000 36.80651 ? 88  ASN B N   1 
ATOM   280  C CA  . ASN A 1 37  ? -5.58000  -12.44000 14.76000  1.000 46.57538 ? 88  ASN B CA  1 
ATOM   281  C C   . ASN A 1 37  ? -5.64000  -11.41200 15.87900  1.000 41.21444 ? 88  ASN B C   1 
ATOM   282  O O   . ASN A 1 37  ? -5.57400  -10.22900 15.62700  1.000 44.08498 ? 88  ASN B O   1 
ATOM   283  C CB  . ASN A 1 37  ? -4.86900  -11.85700 13.53500  1.000 48.34541 ? 88  ASN B CB  1 
ATOM   284  C CG  . ASN A 1 37  ? -3.35900  -11.79000 13.71000  1.000 58.51708 ? 88  ASN B CG  1 
ATOM   285  O OD1 . ASN A 1 37  ? -2.79200  -12.45900 14.57200  1.000 59.57506 ? 88  ASN B OD1 1 
ATOM   286  N ND2 . ASN A 1 37  ? -2.70100  -10.98300 12.88700  1.000 45.28879 ? 88  ASN B ND2 1 
ATOM   287  N N   . PRO A 1 38  ? -5.75600  -11.89600 17.13000  1.000 35.36632 ? 89  PRO B N   1 
ATOM   288  C CA  . PRO A 1 38  ? -5.89900  -10.94800 18.23200  1.000 32.65252 ? 89  PRO B CA  1 
ATOM   289  C C   . PRO A 1 38  ? -4.71100  -10.00400 18.41500  1.000 33.31929 ? 89  PRO B C   1 
ATOM   290  O O   . PRO A 1 38  ? -3.57900  -10.40600 18.24100  1.000 31.02835 ? 89  PRO B O   1 
ATOM   291  C CB  . PRO A 1 38  ? -6.09000  -11.84600 19.44600  1.000 26.62528 ? 89  PRO B CB  1 
ATOM   292  C CG  . PRO A 1 38  ? -6.62800  -13.11300 18.89400  1.000 36.31016 ? 89  PRO B CG  1 
ATOM   293  C CD  . PRO A 1 38  ? -5.89700  -13.28300 17.60300  1.000 30.16505 ? 89  PRO B CD  1 
ATOM   294  N N   . GLU A 1 39  ? -5.00400  -8.76200  18.74200  1.000 26.48824 ? 90  GLU B N   1 
ATOM   295  C CA  . GLU A 1 39  ? -3.96900  -7.76900  18.91300  1.000 30.79431 ? 90  GLU B CA  1 
ATOM   296  C C   . GLU A 1 39  ? -3.21800  -7.87500  20.21700  1.000 34.41147 ? 90  GLU B C   1 
ATOM   297  O O   . GLU A 1 39  ? -2.07200  -7.47900  20.30000  1.000 32.31493 ? 90  GLU B O   1 
ATOM   298  C CB  . GLU A 1 39  ? -4.58900  -6.37900  18.81300  1.000 35.23332 ? 90  GLU B CB  1 
ATOM   299  C CG  . GLU A 1 39  ? -5.16800  -6.04100  17.45100  1.000 50.55424 ? 90  GLU B CG  1 
ATOM   300  C CD  . GLU A 1 39  ? -6.65700  -6.32900  17.32700  1.000 62.59094 ? 90  GLU B CD  1 
ATOM   301  O OE1 . GLU A 1 39  ? -7.19200  -7.17600  18.07800  1.000 49.79821 ? 90  GLU B OE1 1 
ATOM   302  O OE2 . GLU A 1 39  ? -7.29800  -5.69100  16.46900  1.000 62.27931 ? 90  GLU B OE2 1 
ATOM   303  N N   . ASN A 1 40  ? -3.86200  -8.41200  21.23200  1.000 29.94541 ? 91  ASN B N   1 
ATOM   304  C CA  . ASN A 1 40  ? -3.23100  -8.46400  22.51900  1.000 26.17972 ? 91  ASN B CA  1 
ATOM   305  C C   . ASN A 1 40  ? -3.13700  -9.86700  23.06200  1.000 26.36332 ? 91  ASN B C   1 
ATOM   306  O O   . ASN A 1 40  ? -4.10000  -10.41800 23.55200  1.000 24.83735 ? 91  ASN B O   1 
ATOM   307  C CB  . ASN A 1 40  ? -3.95400  -7.53900  23.48700  1.000 25.24858 ? 91  ASN B CB  1 
ATOM   308  C CG  . ASN A 1 40  ? -3.88700  -6.09000  23.06200  1.000 32.90522 ? 91  ASN B CG  1 
ATOM   309  O OD1 . ASN A 1 40  ? -4.87300  -5.36700  23.11700  1.000 28.38903 ? 91  ASN B OD1 1 
ATOM   310  N ND2 . ASN A 1 40  ? -2.71700  -5.66700  22.62700  1.000 31.16509 ? 91  ASN B ND2 1 
ATOM   311  N N   . GLY A 1 41  ? -1.95000  -10.42100 22.98300  1.000 22.36225 ? 92  GLY B N   1 
ATOM   312  C CA  . GLY A 1 41  ? -1.72000  -11.74400 23.51100  1.000 27.83966 ? 92  GLY B CA  1 
ATOM   313  C C   . GLY A 1 41  ? -0.45400  -11.84700 24.33400  1.000 28.52032 ? 92  GLY B C   1 
ATOM   314  O O   . GLY A 1 41  ? -0.36400  -11.23800 25.38000  1.000 28.96783 ? 92  GLY B O   1 
ATOM   315  N N   . THR A 1 42  ? 0.51500   -12.59900 23.84500  1.000 20.72683 ? 93  THR B N   1 
ATOM   316  C CA  . THR A 1 42  ? 1.78100   -12.73700 24.51500  1.000 23.02688 ? 93  THR B CA  1 
ATOM   317  C C   . THR A 1 42  ? 2.63500   -11.50900 24.23900  1.000 20.28612 ? 93  THR B C   1 
ATOM   318  O O   . THR A 1 42  ? 3.51100   -11.55400 23.40900  1.000 24.82463 ? 93  THR B O   1 
ATOM   319  C CB  . THR A 1 42  ? 2.48700   -14.05100 24.10300  1.000 23.10725 ? 93  THR B CB  1 
ATOM   320  O OG1 . THR A 1 42  ? 2.47800   -14.18300 22.68400  1.000 39.76202 ? 93  THR B OG1 1 
ATOM   321  C CG2 . THR A 1 42  ? 1.78700   -15.24500 24.72300  1.000 25.90743 ? 93  THR B CG2 1 
ATOM   322  N N   . CYS A 1 43  ? 2.38400   -10.43800 24.96800  1.000 18.77277 ? 94  CYS B N   1 
ATOM   323  C CA  . CYS A 1 43  ? 3.08100   -9.16700  24.77800  1.000 25.39481 ? 94  CYS B CA  1 
ATOM   324  C C   . CYS A 1 43  ? 4.58500   -9.31900  24.93000  1.000 24.45060 ? 94  CYS B C   1 
ATOM   325  O O   . CYS A 1 43  ? 5.33000   -8.68400  24.22400  1.000 21.88127 ? 94  CYS B O   1 
ATOM   326  C CB  . CYS A 1 43  ? 2.47800   -8.10400  25.74000  1.000 26.86933 ? 94  CYS B CB  1 
ATOM   327  S SG  . CYS A 1 43  ? 2.48100   -8.43500  27.49600  1.000 26.58483 ? 94  CYS B SG  1 
ATOM   328  N N   . TYR A 1 44  ? 5.00900   -10.16000 25.84700  1.000 15.69744 ? 95  TYR B N   1 
ATOM   329  C CA  . TYR A 1 44  ? 6.42100   -10.45900 25.95800  1.000 17.49779 ? 95  TYR B CA  1 
ATOM   330  C C   . TYR A 1 44  ? 6.61400   -11.75000 25.19800  1.000 23.84673 ? 95  TYR B C   1 
ATOM   331  O O   . TYR A 1 44  ? 6.05800   -12.76200 25.55800  1.000 20.05746 ? 95  TYR B O   1 
ATOM   332  C CB  . TYR A 1 44  ? 6.91700   -10.57200 27.37700  1.000 16.93341 ? 95  TYR B CB  1 
ATOM   333  C CG  . TYR A 1 44  ? 8.40800   -10.42700 27.48500  1.000 25.11321 ? 95  TYR B CG  1 
ATOM   334  C CD1 . TYR A 1 44  ? 9.25400   -11.44200 27.07000  1.000 20.43013 ? 95  TYR B CD1 1 
ATOM   335  C CD2 . TYR A 1 44  ? 8.97200   -9.27000  27.99000  1.000 19.21476 ? 95  TYR B CD2 1 
ATOM   336  C CE1 . TYR A 1 44  ? 10.61900  -11.30700 27.15800  1.000 23.06757 ? 95  TYR B CE1 1 
ATOM   337  C CE2 . TYR A 1 44  ? 10.33500  -9.12800  28.08600  1.000 19.02323 ? 95  TYR B CE2 1 
ATOM   338  C CZ  . TYR A 1 44  ? 11.15300  -10.14800 27.66800  1.000 26.07769 ? 95  TYR B CZ  1 
ATOM   339  O OH  . TYR A 1 44  ? 12.50800  -10.00700 27.76200  1.000 27.13752 ? 95  TYR B OH  1 
ATOM   340  N N   . PRO A 1 45  ? 7.43000   -11.70300 24.14600  1.000 22.19670 ? 96  PRO B N   1 
ATOM   341  C CA  . PRO A 1 45  ? 7.57900   -12.86600 23.27200  1.000 17.26406 ? 96  PRO B CA  1 
ATOM   342  C C   . PRO A 1 45  ? 8.06500   -14.16100 23.91800  1.000 20.50755 ? 96  PRO B C   1 
ATOM   343  O O   . PRO A 1 45  ? 8.88800   -14.12700 24.80400  1.000 16.35761 ? 96  PRO B O   1 
ATOM   344  C CB  . PRO A 1 45  ? 8.57500   -12.37200 22.23900  1.000 20.08904 ? 96  PRO B CB  1 
ATOM   345  C CG  . PRO A 1 45  ? 9.31000   -11.26200 22.89000  1.000 23.54523 ? 96  PRO B CG  1 
ATOM   346  C CD  . PRO A 1 45  ? 8.28300   -10.58400 23.72900  1.000 20.15465 ? 96  PRO B CD  1 
ATOM   347  N N   . GLY A 1 46  ? 7.53500   -15.28100 23.44300  1.000 20.02152 ? 97  GLY B N   1 
ATOM   348  C CA  . GLY A 1 46  ? 7.90300   -16.57900 23.95900  1.000 16.70534 ? 97  GLY B CA  1 
ATOM   349  C C   . GLY A 1 46  ? 7.02700   -17.72500 23.50500  1.000 21.04312 ? 97  GLY B C   1 
ATOM   350  O O   . GLY A 1 46  ? 6.03700   -17.51600 22.83800  1.000 15.71700 ? 97  GLY B O   1 
ATOM   351  N N   . HIS A 1 47  ? 7.42100   -18.94000 23.85100  1.000 17.32115 ? 98  HIS B N   1 
ATOM   352  C CA  . HIS A 1 47  ? 6.64100   -20.11100 23.49400  1.000 17.01518 ? 98  HIS B CA  1 
ATOM   353  C C   . HIS A 1 47  ? 5.63100   -20.49000 24.56700  1.000 17.26849 ? 98  HIS B C   1 
ATOM   354  O O   . HIS A 1 47  ? 5.99000   -20.68800 25.70500  1.000 19.71104 ? 98  HIS B O   1 
ATOM   355  C CB  . HIS A 1 47  ? 7.54000   -21.30500 23.20100  1.000 15.40082 ? 98  HIS B CB  1 
ATOM   356  C CG  . HIS A 1 47  ? 6.82100   -22.47200 22.61400  1.000 16.71558 ? 98  HIS B CG  1 
ATOM   357  N ND1 . HIS A 1 47  ? 7.08300   -23.76800 22.98900  1.000 21.68554 ? 98  HIS B ND1 1 
ATOM   358  C CD2 . HIS A 1 47  ? 5.85000   -22.53900 21.67700  1.000 19.17921 ? 98  HIS B CD2 1 
ATOM   359  C CE1 . HIS A 1 47  ? 6.30200   -24.58500 22.30800  1.000 25.57054 ? 98  HIS B CE1 1 
ATOM   360  N NE2 . HIS A 1 47  ? 5.54100   -23.86400 21.50900  1.000 20.31069 ? 98  HIS B NE2 1 
ATOM   361  N N   . PHE A 1 48  ? 4.37600   -20.55200 24.19000  1.000 18.33437 ? 99  PHE B N   1 
ATOM   362  C CA  . PHE A 1 48  ? 3.31800   -20.94000 25.11400  1.000 19.91098 ? 99  PHE B CA  1 
ATOM   363  C C   . PHE A 1 48  ? 3.07600   -22.42500 24.97700  1.000 21.08110 ? 99  PHE B C   1 
ATOM   364  O O   . PHE A 1 48  ? 2.46000   -22.87500 24.04000  1.000 22.02469 ? 99  PHE B O   1 
ATOM   365  C CB  . PHE A 1 48  ? 2.03400   -20.13400 24.89500  1.000 21.48278 ? 99  PHE B CB  1 
ATOM   366  C CG  . PHE A 1 48  ? 1.08100   -20.18100 26.04900  1.000 20.02543 ? 99  PHE B CG  1 
ATOM   367  C CD1 . PHE A 1 48  ? 0.63000   -21.38600 26.54600  1.000 17.78317 ? 99  PHE B CD1 1 
ATOM   368  C CD2 . PHE A 1 48  ? 0.62800   -19.01200 26.63100  1.000 20.86488 ? 99  PHE B CD2 1 
ATOM   369  C CE1 . PHE A 1 48  ? -0.24800  -21.42500 27.60900  1.000 23.38347 ? 99  PHE B CE1 1 
ATOM   370  C CE2 . PHE A 1 48  ? -0.25000  -19.04400 27.69200  1.000 17.68928 ? 99  PHE B CE2 1 
ATOM   371  C CZ  . PHE A 1 48  ? -0.68800  -20.25200 28.18300  1.000 19.66935 ? 99  PHE B CZ  1 
ATOM   372  N N   . ALA A 1 49  ? 3.57600   -23.16900 25.92700  1.000 20.41763 ? 100 ALA B N   1 
ATOM   373  C CA  . ALA A 1 49  ? 3.47600   -24.59900 25.85800  1.000 20.29125 ? 100 ALA B CA  1 
ATOM   374  C C   . ALA A 1 49  ? 2.06400   -25.17300 25.95000  1.000 27.18100 ? 100 ALA B C   1 
ATOM   375  O O   . ALA A 1 49  ? 1.23800   -24.66900 26.68300  1.000 24.30550 ? 100 ALA B O   1 
ATOM   376  C CB  . ALA A 1 49  ? 4.34300   -25.18800 26.92600  1.000 18.18346 ? 100 ALA B CB  1 
ATOM   377  N N   . ASP A 1 50  ? 1.81000   -26.20500 25.16100  1.000 29.48093 ? 101 ASP B N   1 
ATOM   378  C CA  . ASP A 1 50  ? 0.52100   -26.88500 25.19900  1.000 24.19634 ? 101 ASP B CA  1 
ATOM   379  C C   . ASP A 1 50  ? -0.63700  -25.91600 25.10600  1.000 25.12187 ? 101 ASP B C   1 
ATOM   380  O O   . ASP A 1 50  ? -1.60800  -26.05500 25.80800  1.000 27.47915 ? 101 ASP B O   1 
ATOM   381  C CB  . ASP A 1 50  ? 0.46100   -27.68500 26.47900  1.000 30.40189 ? 101 ASP B CB  1 
ATOM   382  C CG  . ASP A 1 50  ? 1.62200   -28.65700 26.62500  1.000 34.93928 ? 101 ASP B CG  1 
ATOM   383  O OD1 . ASP A 1 50  ? 1.87900   -29.44000 25.69300  1.000 33.91128 ? 101 ASP B OD1 1 
ATOM   384  O OD2 . ASP A 1 50  ? 2.26500   -28.64700 27.68600  1.000 33.09897 ? 101 ASP B OD2 1 
ATOM   385  N N   . TYR A 1 51  ? -0.50900  -24.93000 24.23800  1.000 24.69793 ? 102 TYR B N   1 
ATOM   386  C CA  . TYR A 1 51  ? -1.50900  -23.88100 24.14600  1.000 27.18048 ? 102 TYR B CA  1 
ATOM   387  C C   . TYR A 1 51  ? -2.84400  -24.34400 23.60900  1.000 27.06582 ? 102 TYR B C   1 
ATOM   388  O O   . TYR A 1 51  ? -3.85900  -23.98900 24.14300  1.000 26.51869 ? 102 TYR B O   1 
ATOM   389  C CB  . TYR A 1 51  ? -0.95000  -22.74100 23.29500  1.000 23.40606 ? 102 TYR B CB  1 
ATOM   390  C CG  . TYR A 1 51  ? -1.82800  -21.52600 23.16600  1.000 20.11718 ? 102 TYR B CG  1 
ATOM   391  C CD1 . TYR A 1 51  ? -2.27300  -20.84900 24.28400  1.000 18.35319 ? 102 TYR B CD1 1 
ATOM   392  C CD2 . TYR A 1 51  ? -2.17900  -21.03300 21.92100  1.000 21.63055 ? 102 TYR B CD2 1 
ATOM   393  C CE1 . TYR A 1 51  ? -3.06800  -19.72800 24.16700  1.000 23.41033 ? 102 TYR B CE1 1 
ATOM   394  C CE2 . TYR A 1 51  ? -2.97000  -19.91400 21.79300  1.000 17.71795 ? 102 TYR B CE2 1 
ATOM   395  C CZ  . TYR A 1 51  ? -3.41200  -19.26600 22.92200  1.000 25.75066 ? 102 TYR B CZ  1 
ATOM   396  O OH  . TYR A 1 51  ? -4.19700  -18.15600 22.80900  1.000 27.55509 ? 102 TYR B OH  1 
ATOM   397  N N   . GLU A 1 52  ? -2.80800  -25.12500 22.54200  1.000 30.20468 ? 103 GLU B N   1 
ATOM   398  C CA  . GLU A 1 52  ? -4.02400  -25.60100 21.92300  1.000 29.81439 ? 103 GLU B CA  1 
ATOM   399  C C   . GLU A 1 52  ? -4.78900  -26.49600 22.87500  1.000 32.99840 ? 103 GLU B C   1 
ATOM   400  O O   . GLU A 1 52  ? -5.99700  -26.41600 22.93600  1.000 29.83820 ? 103 GLU B O   1 
ATOM   401  C CB  . GLU A 1 52  ? -3.69300  -26.28900 20.62200  1.000 39.09419 ? 103 GLU B CB  1 
ATOM   402  C CG  . GLU A 1 52  ? -3.18600  -25.33600 19.54800  1.000 46.96635 ? 103 GLU B CG  1 
ATOM   403  C CD  . GLU A 1 52  ? -4.22700  -24.31800 19.11300  1.000 55.25191 ? 103 GLU B CD  1 
ATOM   404  O OE1 . GLU A 1 52  ? -5.43100  -24.56800 19.31200  1.000 56.75338 ? 103 GLU B OE1 1 
ATOM   405  O OE2 . GLU A 1 52  ? -3.84500  -23.26700 18.55900  1.000 50.23407 ? 103 GLU B OE2 1 
ATOM   406  N N   . GLU A 1 53  ? -4.08600  -27.30500 23.63900  1.000 23.45288 ? 104 GLU B N   1 
ATOM   407  C CA  . GLU A 1 53  ? -4.74100  -28.08600 24.64700  1.000 26.40923 ? 104 GLU B CA  1 
ATOM   408  C C   . GLU A 1 53  ? -5.38700  -27.15300 25.67500  1.000 32.33458 ? 104 GLU B C   1 
ATOM   409  O O   . GLU A 1 53  ? -6.51800  -27.36100 26.06200  1.000 36.93300 ? 104 GLU B O   1 
ATOM   410  C CB  . GLU A 1 53  ? -3.77800  -29.03600 25.33900  1.000 24.60511 ? 104 GLU B CB  1 
ATOM   411  C CG  . GLU A 1 53  ? -4.42200  -29.86700 26.42700  1.000 39.66086 ? 104 GLU B CG  1 
ATOM   412  C CD  . GLU A 1 53  ? -3.44500  -30.79000 27.12600  1.000 50.93612 ? 104 GLU B CD  1 
ATOM   413  O OE1 . GLU A 1 53  ? -2.25300  -30.79900 26.76200  1.000 44.38811 ? 104 GLU B OE1 1 
ATOM   414  O OE2 . GLU A 1 53  ? -3.87500  -31.50800 28.04600  1.000 52.02715 ? 104 GLU B OE2 1 
ATOM   415  N N   . LEU A 1 54  ? -4.67300  -26.12200 26.09600  1.000 24.54434 ? 105 LEU B N   1 
ATOM   416  C CA  . LEU A 1 54  ? -5.21400  -25.19400 27.07300  1.000 28.44354 ? 105 LEU B CA  1 
ATOM   417  C C   . LEU A 1 54  ? -6.45800  -24.53100 26.52700  1.000 26.19662 ? 105 LEU B C   1 
ATOM   418  O O   . LEU A 1 54  ? -7.43000  -24.40200 27.23900  1.000 28.53624 ? 105 LEU B O   1 
ATOM   419  C CB  . LEU A 1 54  ? -4.18900  -24.15300 27.49000  1.000 22.91097 ? 105 LEU B CB  1 
ATOM   420  C CG  . LEU A 1 54  ? -4.56900  -23.21400 28.63300  1.000 26.38692 ? 105 LEU B CG  1 
ATOM   421  C CD1 . LEU A 1 54  ? -4.94100  -23.99500 29.87900  1.000 23.51066 ? 105 LEU B CD1 1 
ATOM   422  C CD2 . LEU A 1 54  ? -3.43300  -22.25300 28.92500  1.000 25.77648 ? 105 LEU B CD2 1 
ATOM   423  N N   . ARG A 1 55  ? -6.41800  -24.12200 25.27400  1.000 21.93189 ? 106 ARG B N   1 
ATOM   424  C CA  . ARG A 1 55  ? -7.55800  -23.53000 24.63300  1.000 28.58914 ? 106 ARG B CA  1 
ATOM   425  C C   . ARG A 1 55  ? -8.76800  -24.48300 24.66200  1.000 28.70692 ? 106 ARG B C   1 
ATOM   426  O O   . ARG A 1 55  ? -9.88200  -24.05800 24.88900  1.000 25.90424 ? 106 ARG B O   1 
ATOM   427  C CB  . ARG A 1 55  ? -7.16600  -23.15200 23.21100  1.000 27.12653 ? 106 ARG B CB  1 
ATOM   428  C CG  . ARG A 1 55  ? -6.30700  -21.91600 23.06500  1.000 31.86130 ? 106 ARG B CG  1 
ATOM   429  C CD  . ARG A 1 55  ? -6.45000  -21.37200 21.65800  1.000 36.32065 ? 106 ARG B CD  1 
ATOM   430  N NE  . ARG A 1 55  ? -7.85300  -21.14000 21.35200  1.000 50.98541 ? 106 ARG B NE  1 
ATOM   431  C CZ  . ARG A 1 55  ? -8.31400  -20.70300 20.18500  1.000 59.84490 ? 106 ARG B CZ  1 
ATOM   432  N NH1 . ARG A 1 55  ? -7.48000  -20.45000 19.19000  1.000 69.94160 ? 106 ARG B NH1 1 
ATOM   433  N NH2 . ARG A 1 55  ? -9.61600  -20.52400 20.01400  1.000 49.00902 ? 106 ARG B NH2 1 
ATOM   434  N N   . GLU A 1 56  ? -8.53100  -25.76700 24.44200  1.000 32.87332 ? 107 GLU B N   1 
ATOM   435  C CA  . GLU A 1 56  ? -9.58500  -26.76000 24.48000  1.000 35.30740 ? 107 GLU B CA  1 
ATOM   436  C C   . GLU A 1 56  ? -10.09700 -27.01000 25.88600  1.000 37.91024 ? 107 GLU B C   1 
ATOM   437  O O   . GLU A 1 56  ? -11.27400 -27.22600 26.07800  1.000 39.77066 ? 107 GLU B O   1 
ATOM   438  C CB  . GLU A 1 56  ? -9.08100  -28.07400 23.91400  1.000 36.55514 ? 107 GLU B CB  1 
ATOM   439  C CG  . GLU A 1 56  ? -8.62300  -28.02500 22.46900  1.000 44.48221 ? 107 GLU B CG  1 
ATOM   440  C CD  . GLU A 1 56  ? -7.95300  -29.31400 22.03100  1.000 57.09205 ? 107 GLU B CD  1 
ATOM   441  O OE1 . GLU A 1 56  ? -7.88300  -30.26200 22.84300  1.000 51.66876 ? 107 GLU B OE1 1 
ATOM   442  O OE2 . GLU A 1 56  ? -7.49600  -29.38100 20.87500  1.000 55.48146 ? 107 GLU B OE2 1 
ATOM   443  N N   . GLN A 1 57  ? -9.21300  -26.98500 26.86100  1.000 30.17804 ? 108 GLN B N   1 
ATOM   444  C CA  . GLN A 1 57  ? -9.61700  -27.28200 28.21600  1.000 30.09020 ? 108 GLN B CA  1 
ATOM   445  C C   . GLN A 1 57  ? -10.36200 -26.11000 28.84300  1.000 32.76517 ? 108 GLN B C   1 
ATOM   446  O O   . GLN A 1 57  ? -11.01300 -26.26900 29.84600  1.000 41.29143 ? 108 GLN B O   1 
ATOM   447  C CB  . GLN A 1 57  ? -8.40700  -27.67800 29.07000  1.000 32.76232 ? 108 GLN B CB  1 
ATOM   448  C CG  . GLN A 1 57  ? -7.60900  -28.86800 28.56700  1.000 41.51215 ? 108 GLN B CG  1 
ATOM   449  C CD  . GLN A 1 57  ? -8.37800  -30.17200 28.62000  1.000 51.25518 ? 108 GLN B CD  1 
ATOM   450  O OE1 . GLN A 1 57  ? -9.53800  -30.21000 29.01500  1.000 52.98140 ? 108 GLN B OE1 1 
ATOM   451  N NE2 . GLN A 1 57  ? -7.72700  -31.25300 28.22200  1.000 58.07908 ? 108 GLN B NE2 1 
ATOM   452  N N   . LEU A 1 58  ? -10.26500 -24.94600 28.24000  1.000 27.94493 ? 109 LEU B N   1 
ATOM   453  C CA  . LEU A 1 58  ? -10.91800 -23.77700 28.77600  1.000 33.77589 ? 109 LEU B CA  1 
ATOM   454  C C   . LEU A 1 58  ? -12.12300 -23.39200 27.92900  1.000 33.39223 ? 109 LEU B C   1 
ATOM   455  O O   . LEU A 1 58  ? -12.75200 -22.38200 28.17500  1.000 32.55303 ? 109 LEU B O   1 
ATOM   456  C CB  . LEU A 1 58  ? -9.91100  -22.64300 28.87700  1.000 31.92688 ? 109 LEU B CB  1 
ATOM   457  C CG  . LEU A 1 58  ? -8.80800  -22.75900 29.92200  1.000 28.51634 ? 109 LEU B CG  1 
ATOM   458  C CD1 . LEU A 1 58  ? -7.86200  -21.58100 29.82000  1.000 22.17270 ? 109 LEU B CD1 1 
ATOM   459  C CD2 . LEU A 1 58  ? -9.41400  -22.83000 31.30700  1.000 31.57256 ? 109 LEU B CD2 1 
ATOM   460  N N   . SER A 1 59  ? -12.44200 -24.21600 26.94600  1.000 34.12401 ? 110 SER B N   1 
ATOM   461  C CA  . SER A 1 59  ? -13.54500 -23.93700 26.03400  1.000 35.77251 ? 110 SER B CA  1 
ATOM   462  C C   . SER A 1 59  ? -14.87800 -23.95000 26.74000  1.000 30.98764 ? 110 SER B C   1 
ATOM   463  O O   . SER A 1 59  ? -15.75100 -23.18300 26.41200  1.000 38.59973 ? 110 SER B O   1 
ATOM   464  C CB  . SER A 1 59  ? -13.54100 -24.94400 24.87700  1.000 35.51992 ? 110 SER B CB  1 
ATOM   465  O OG  . SER A 1 59  ? -13.94100 -26.22600 25.29900  1.000 43.10315 ? 110 SER B OG  1 
ATOM   466  N N   . SER A 1 60  ? -15.02000 -24.82000 27.71100  1.000 30.73910 ? 111 SER B N   1 
ATOM   467  C CA  . SER A 1 60  ? -16.24100 -24.89100 28.48000  1.000 37.91376 ? 111 SER B CA  1 
ATOM   468  C C   . SER A 1 60  ? -15.91000 -25.02600 29.94900  1.000 34.17193 ? 111 SER B C   1 
ATOM   469  O O   . SER A 1 60  ? -15.29100 -25.98800 30.35800  1.000 40.24076 ? 111 SER B O   1 
ATOM   470  C CB  . SER A 1 60  ? -17.14100 -26.03500 27.98000  1.000 35.61271 ? 111 SER B CB  1 
ATOM   471  O OG  . SER A 1 60  ? -18.44800 -25.91500 28.49000  1.000 56.70681 ? 111 SER B OG  1 
ATOM   472  N N   . VAL A 1 61  ? -16.33300 -24.06000 30.73800  1.000 36.41174 ? 112 VAL B N   1 
ATOM   473  C CA  . VAL A 1 61  ? -16.03900 -24.04100 32.15600  1.000 41.10142 ? 112 VAL B CA  1 
ATOM   474  C C   . VAL A 1 61  ? -17.30700 -23.77700 32.94800  1.000 40.62894 ? 112 VAL B C   1 
ATOM   475  O O   . VAL A 1 61  ? -18.11300 -22.94900 32.56300  1.000 39.31197 ? 112 VAL B O   1 
ATOM   476  C CB  . VAL A 1 61  ? -14.98000 -22.96800 32.48500  1.000 38.92988 ? 112 VAL B CB  1 
ATOM   477  C CG1 . VAL A 1 61  ? -14.77600 -22.83200 33.97700  1.000 42.41586 ? 112 VAL B CG1 1 
ATOM   478  C CG2 . VAL A 1 61  ? -13.67300 -23.28200 31.77900  1.000 35.74600 ? 112 VAL B CG2 1 
ATOM   479  N N   . SER A 1 62  ? -17.47600 -24.48800 34.05000  1.000 46.98070 ? 113 SER B N   1 
ATOM   480  C CA  . SER A 1 62  ? -18.67500 -24.35200 34.87400  1.000 52.00138 ? 113 SER B CA  1 
ATOM   481  C C   . SER A 1 62  ? -18.41800 -23.44400 36.04200  1.000 47.62403 ? 113 SER B C   1 
ATOM   482  O O   . SER A 1 62  ? -19.31500 -22.76100 36.48700  1.000 52.16032 ? 113 SER B O   1 
ATOM   483  C CB  . SER A 1 62  ? -19.13400 -25.70700 35.39700  1.000 41.82376 ? 113 SER B CB  1 
ATOM   484  O OG  . SER A 1 62  ? -18.40800 -26.08900 36.54300  1.000 58.48597 ? 113 SER B OG  1 
ATOM   485  N N   . SER A 1 63  ? -17.20800 -23.45200 36.55400  1.000 38.44297 ? 114 SER B N   1 
ATOM   486  C CA  . SER A 1 63  ? -16.86400 -22.55400 37.63900  1.000 43.13170 ? 114 SER B CA  1 
ATOM   487  C C   . SER A 1 63  ? -15.46900 -22.01000 37.40400  1.000 46.91855 ? 114 SER B C   1 
ATOM   488  O O   . SER A 1 63  ? -14.59600 -22.73200 36.97700  1.000 43.01394 ? 114 SER B O   1 
ATOM   489  C CB  . SER A 1 63  ? -16.97000 -23.23000 39.00400  1.000 41.53667 ? 114 SER B CB  1 
ATOM   490  O OG  . SER A 1 63  ? -16.85600 -22.29200 40.05100  1.000 52.39395 ? 114 SER B OG  1 
ATOM   491  N N   . PHE A 1 64  ? -15.29000 -20.72500 37.64800  1.000 41.57809 ? 115 PHE B N   1 
ATOM   492  C CA  . PHE A 1 64  ? -14.01100 -20.09700 37.42900  1.000 38.96669 ? 115 PHE B CA  1 
ATOM   493  C C   . PHE A 1 64  ? -13.75100 -19.06900 38.50500  1.000 38.13206 ? 115 PHE B C   1 
ATOM   494  O O   . PHE A 1 64  ? -14.54000 -18.16300 38.70100  1.000 37.46950 ? 115 PHE B O   1 
ATOM   495  C CB  . PHE A 1 64  ? -13.98100 -19.44100 36.05600  1.000 33.49149 ? 115 PHE B CB  1 
ATOM   496  C CG  . PHE A 1 64  ? -12.60700 -19.18700 35.53300  1.000 37.42635 ? 115 PHE B CG  1 
ATOM   497  C CD1 . PHE A 1 64  ? -11.81100 -20.23300 35.12100  1.000 34.23638 ? 115 PHE B CD1 1 
ATOM   498  C CD2 . PHE A 1 64  ? -12.12000 -17.90000 35.43200  1.000 37.48168 ? 115 PHE B CD2 1 
ATOM   499  C CE1 . PHE A 1 64  ? -10.54900 -20.00300 34.62600  1.000 35.38597 ? 115 PHE B CE1 1 
ATOM   500  C CE2 . PHE A 1 64  ? -10.85300 -17.66300 34.94200  1.000 33.63478 ? 115 PHE B CE2 1 
ATOM   501  C CZ  . PHE A 1 64  ? -10.06800 -18.71700 34.54100  1.000 28.72876 ? 115 PHE B CZ  1 
ATOM   502  N N   . GLU A 1 65  ? -12.64100 -19.21500 39.19700  1.000 30.89119 ? 116 GLU B N   1 
ATOM   503  C CA  . GLU A 1 65  ? -12.29200 -18.28000 40.21900  1.000 31.86600 ? 116 GLU B CA  1 
ATOM   504  C C   . GLU A 1 65  ? -10.80900 -17.97100 40.24300  1.000 34.50155 ? 116 GLU B C   1 
ATOM   505  O O   . GLU A 1 65  ? -10.00100 -18.86200 40.41200  1.000 35.65817 ? 116 GLU B O   1 
ATOM   506  C CB  . GLU A 1 65  ? -12.70600 -18.82900 41.57500  1.000 37.78089 ? 116 GLU B CB  1 
ATOM   507  C CG  . GLU A 1 65  ? -12.15900 -18.06100 42.76100  1.000 47.12083 ? 116 GLU B CG  1 
ATOM   508  C CD  . GLU A 1 65  ? -12.15300 -18.88500 44.03300  1.000 66.34354 ? 116 GLU B CD  1 
ATOM   509  O OE1 . GLU A 1 65  ? -12.70500 -20.00400 44.02500  1.000 64.09470 ? 116 GLU B OE1 1 
ATOM   510  O OE2 . GLU A 1 65  ? -11.59300 -18.41300 45.04000  1.000 64.70777 ? 116 GLU B OE2 1 
ATOM   511  N N   . ARG A 1 66  ? -10.46400 -16.70800 40.09400  1.000 30.39081 ? 117 ARG B N   1 
ATOM   512  C CA  . ARG A 1 66  ? -9.07700  -16.29900 40.17400  1.000 32.81781 ? 117 ARG B CA  1 
ATOM   513  C C   . ARG A 1 66  ? -8.70800  -15.93100 41.58200  1.000 37.13747 ? 117 ARG B C   1 
ATOM   514  O O   . ARG A 1 66  ? -9.41100  -15.17200 42.22300  1.000 44.75138 ? 117 ARG B O   1 
ATOM   515  C CB  . ARG A 1 66  ? -8.78400  -15.11000 39.28300  1.000 30.25134 ? 117 ARG B CB  1 
ATOM   516  C CG  . ARG A 1 66  ? -7.32700  -14.69900 39.29900  1.000 37.98976 ? 117 ARG B CG  1 
ATOM   517  C CD  . ARG A 1 66  ? -7.07700  -13.44100 38.49500  1.000 34.70060 ? 117 ARG B CD  1 
ATOM   518  N NE  . ARG A 1 66  ? -7.71500  -12.29000 39.10600  1.000 47.22228 ? 117 ARG B NE  1 
ATOM   519  C CZ  . ARG A 1 66  ? -7.37400  -11.03700 38.85200  1.000 49.68609 ? 117 ARG B CZ  1 
ATOM   520  N NH1 . ARG A 1 66  ? -6.38700  -10.78300 38.01000  1.000 54.46018 ? 117 ARG B NH1 1 
ATOM   521  N NH2 . ARG A 1 66  ? -8.00300  -10.04200 39.45200  1.000 48.69291 ? 117 ARG B NH2 1 
ATOM   522  N N   . PHE A 1 67  ? -7.59600  -16.45300 42.05900  1.000 41.33406 ? 118 PHE B N   1 
ATOM   523  C CA  . PHE A 1 67  ? -7.11400  -16.12700 43.38600  1.000 37.87966 ? 118 PHE B CA  1 
ATOM   524  C C   . PHE A 1 67  ? -5.59300  -15.93000 43.39200  1.000 42.18597 ? 118 PHE B C   1 
ATOM   525  O O   . PHE A 1 67  ? -4.90700  -16.43300 42.51900  1.000 37.31109 ? 118 PHE B O   1 
ATOM   526  C CB  . PHE A 1 67  ? -7.52100  -17.21900 44.35400  1.000 34.29374 ? 118 PHE B CB  1 
ATOM   527  C CG  . PHE A 1 67  ? -6.83000  -18.52800 44.13800  1.000 38.80046 ? 118 PHE B CG  1 
ATOM   528  C CD1 . PHE A 1 67  ? -7.26800  -19.40600 43.16800  1.000 39.35171 ? 118 PHE B CD1 1 
ATOM   529  C CD2 . PHE A 1 67  ? -5.75900  -18.89400 44.93200  1.000 34.74123 ? 118 PHE B CD2 1 
ATOM   530  C CE1 . PHE A 1 67  ? -6.63900  -20.61700 42.98000  1.000 38.35721 ? 118 PHE B CE1 1 
ATOM   531  C CE2 . PHE A 1 67  ? -5.12900  -20.10300 44.75100  1.000 29.42696 ? 118 PHE B CE2 1 
ATOM   532  C CZ  . PHE A 1 67  ? -5.56900  -20.96600 43.77500  1.000 36.12504 ? 118 PHE B CZ  1 
ATOM   533  N N   . GLU A 1 68  ? -5.07300  -15.21400 44.38200  1.000 43.94490 ? 119 GLU B N   1 
ATOM   534  C CA  . GLU A 1 68  ? -3.63700  -14.98700 44.48300  1.000 37.77406 ? 119 GLU B CA  1 
ATOM   535  C C   . GLU A 1 68  ? -2.93400  -16.13100 45.14500  1.000 42.16142 ? 119 GLU B C   1 
ATOM   536  O O   . GLU A 1 68  ? -2.71900  -16.11100 46.34000  1.000 47.33239 ? 119 GLU B O   1 
ATOM   537  C CB  . GLU A 1 68  ? -3.34100  -13.70800 45.24600  1.000 47.23407 ? 119 GLU B CB  1 
ATOM   538  C CG  . GLU A 1 68  ? -2.38100  -12.75200 44.56300  1.000 49.04212 ? 119 GLU B CG  1 
ATOM   539  C CD  . GLU A 1 68  ? -2.27100  -11.42300 45.28700  1.000 52.96803 ? 119 GLU B CD  1 
ATOM   540  O OE1 . GLU A 1 68  ? -2.88600  -11.29100 46.35800  1.000 57.26701 ? 119 GLU B OE1 1 
ATOM   541  O OE2 . GLU A 1 68  ? -1.57500  -10.51400 44.79200  1.000 45.14477 ? 119 GLU B OE2 1 
ATOM   542  N N   . ILE A 1 69  ? -2.56200  -17.12400 44.36600  1.000 30.76912 ? 120 ILE B N   1 
ATOM   543  C CA  . ILE A 1 69  ? -1.86100  -18.27200 44.89900  1.000 35.16152 ? 120 ILE B CA  1 
ATOM   544  C C   . ILE A 1 69  ? -0.61000  -17.86300 45.65500  1.000 34.45690 ? 120 ILE B C   1 
ATOM   545  O O   . ILE A 1 69  ? -0.30500  -18.43700 46.67200  1.000 45.47123 ? 120 ILE B O   1 
ATOM   546  C CB  . ILE A 1 69  ? -1.51200  -19.26800 43.76800  1.000 34.99023 ? 120 ILE B CB  1 
ATOM   547  C CG1 . ILE A 1 69  ? -0.89700  -20.54500 44.32400  1.000 36.26100 ? 120 ILE B CG1 1 
ATOM   548  C CG2 . ILE A 1 69  ? -0.58900  -18.61700 42.74600  1.000 34.31111 ? 120 ILE B CG2 1 
ATOM   549  C CD1 . ILE A 1 69  ? -0.67400  -21.59400 43.26400  1.000 34.32616 ? 120 ILE B CD1 1 
ATOM   550  N N   . PHE A 1 70  ? 0.09600   -16.87100 45.16100  1.000 38.78909 ? 121 PHE B N   1 
ATOM   551  C CA  . PHE A 1 70  ? 1.31800   -16.40100 45.78800  1.000 36.09043 ? 121 PHE B CA  1 
ATOM   552  C C   . PHE A 1 70  ? 1.23200   -14.89200 45.89000  1.000 36.97310 ? 121 PHE B C   1 
ATOM   553  O O   . PHE A 1 70  ? 1.64200   -14.18100 45.00800  1.000 38.72950 ? 121 PHE B O   1 
ATOM   554  C CB  . PHE A 1 70  ? 2.54200   -16.81400 44.98900  1.000 32.87372 ? 121 PHE B CB  1 
ATOM   555  C CG  . PHE A 1 70  ? 2.77200   -18.29000 44.92900  1.000 34.58721 ? 121 PHE B CG  1 
ATOM   556  C CD1 . PHE A 1 70  ? 2.71900   -19.06000 46.07200  1.000 33.80325 ? 121 PHE B CD1 1 
ATOM   557  C CD2 . PHE A 1 70  ? 3.07400   -18.90200 43.73100  1.000 27.64086 ? 121 PHE B CD2 1 
ATOM   558  C CE1 . PHE A 1 70  ? 2.93600   -20.41800 46.01600  1.000 38.38705 ? 121 PHE B CE1 1 
ATOM   559  C CE2 . PHE A 1 70  ? 3.29600   -20.25900 43.66800  1.000 31.54638 ? 121 PHE B CE2 1 
ATOM   560  C CZ  . PHE A 1 70  ? 3.22800   -21.02000 44.81200  1.000 39.13774 ? 121 PHE B CZ  1 
ATOM   561  N N   . PRO A 1 71  ? 0.66700   -14.40400 46.98200  1.000 41.12924 ? 122 PRO B N   1 
ATOM   562  C CA  . PRO A 1 71  ? 0.46700   -12.96400 47.10900  1.000 40.38803 ? 122 PRO B CA  1 
ATOM   563  C C   . PRO A 1 71  ? 1.75000   -12.18300 47.00500  1.000 46.26354 ? 122 PRO B C   1 
ATOM   564  O O   . PRO A 1 71  ? 2.74000   -12.54300 47.61300  1.000 45.46399 ? 122 PRO B O   1 
ATOM   565  C CB  . PRO A 1 71  ? -0.13900  -12.84100 48.50000  1.000 48.00923 ? 122 PRO B CB  1 
ATOM   566  C CG  . PRO A 1 71  ? -0.83400  -14.13600 48.72300  1.000 41.48415 ? 122 PRO B CG  1 
ATOM   567  C CD  . PRO A 1 71  ? 0.05700   -15.15300 48.08900  1.000 41.07649 ? 122 PRO B CD  1 
ATOM   568  N N   . LYS A 1 72  ? 1.71600   -11.10100 46.26200  1.000 45.25241 ? 123 LYS B N   1 
ATOM   569  C CA  . LYS A 1 72  ? 2.90200   -10.30300 46.03300  1.000 51.13364 ? 123 LYS B CA  1 
ATOM   570  C C   . LYS A 1 72  ? 3.50700   -9.67200  47.26300  1.000 53.92176 ? 123 LYS B C   1 
ATOM   571  O O   . LYS A 1 72  ? 4.71000   -9.57600  47.38900  1.000 52.55599 ? 123 LYS B O   1 
ATOM   572  C CB  . LYS A 1 72  ? 2.53100   -9.19000  45.06900  1.000 48.42619 ? 123 LYS B CB  1 
ATOM   573  C CG  . LYS A 1 72  ? 3.64500   -8.19900  44.79800  1.000 59.54057 ? 123 LYS B CG  1 
ATOM   574  C CD  . LYS A 1 72  ? 3.13000   -7.01000  44.01000  1.000 64.55254 ? 123 LYS B CD  1 
ATOM   575  C CE  . LYS A 1 72  ? 4.23200   -5.99400  43.76800  1.000 64.99482 ? 123 LYS B CE  1 
ATOM   576  N NZ  . LYS A 1 72  ? 3.70700   -4.75400  43.13500  1.000 72.05407 ? 123 LYS B NZ  1 
ATOM   577  N N   . GLU A 1 73  ? 2.67100   -9.25300  48.17500  1.000 55.62226 ? 124 GLU B N   1 
ATOM   578  C CA  . GLU A 1 73  ? 3.15700   -8.53000  49.32800  1.000 62.91423 ? 124 GLU B CA  1 
ATOM   579  C C   . GLU A 1 73  ? 3.85800   -9.36500  50.39700  1.000 54.34485 ? 124 GLU B C   1 
ATOM   580  O O   . GLU A 1 73  ? 4.56400   -8.81700  51.21900  1.000 62.63462 ? 124 GLU B O   1 
ATOM   581  C CB  . GLU A 1 73  ? 1.96700   -7.76200  49.91800  1.000 61.38395 ? 124 GLU B CB  1 
ATOM   582  C CG  . GLU A 1 73  ? 1.32100   -6.78200  48.95000  1.000 54.23376 ? 124 GLU B CG  1 
ATOM   583  C CD  . GLU A 1 73  ? 0.44100   -7.45400  47.90600  1.000 76.15112 ? 124 GLU B CD  1 
ATOM   584  O OE1 . GLU A 1 73  ? 0.15800   -8.66200  48.04000  1.000 71.83022 ? 124 GLU B OE1 1 
ATOM   585  O OE2 . GLU A 1 73  ? 0.02000   -6.77000  46.94800  1.000 75.23947 ? 124 GLU B OE2 1 
ATOM   586  N N   . SER A 1 74  ? 3.70100   -10.67600 50.36600  1.000 53.86914 ? 125 SER B N   1 
ATOM   587  C CA  . SER A 1 74  ? 4.26600   -11.50600 51.39900  1.000 49.61932 ? 125 SER B CA  1 
ATOM   588  C C   . SER A 1 74  ? 5.02900   -12.71200 50.93700  1.000 50.18909 ? 125 SER B C   1 
ATOM   589  O O   . SER A 1 74  ? 5.66000   -13.37800 51.74000  1.000 47.87249 ? 125 SER B O   1 
ATOM   590  C CB  . SER A 1 74  ? 3.11400   -12.05200 52.22700  1.000 50.05681 ? 125 SER B CB  1 
ATOM   591  O OG  . SER A 1 74  ? 2.49000   -13.13900 51.57600  1.000 48.64555 ? 125 SER B OG  1 
ATOM   592  N N   . SER A 1 75  ? 4.95900   -13.03500 49.66200  1.000 44.50392 ? 126 SER B N   1 
ATOM   593  C CA  . SER A 1 75  ? 5.56800   -14.28700 49.23200  1.000 45.89725 ? 126 SER B CA  1 
ATOM   594  C C   . SER A 1 75  ? 7.03600   -14.17300 48.87300  1.000 37.37326 ? 126 SER B C   1 
ATOM   595  O O   . SER A 1 75  ? 7.74900   -15.14900 48.93300  1.000 36.42269 ? 126 SER B O   1 
ATOM   596  C CB  . SER A 1 75  ? 4.76700   -14.87500 48.05300  1.000 45.19825 ? 126 SER B CB  1 
ATOM   597  O OG  . SER A 1 75  ? 3.37500   -14.87500 48.30800  1.000 40.83762 ? 126 SER B OG  1 
ATOM   598  N N   . TRP A 1 76  ? 7.49000   -12.97700 48.54500  1.000 37.21131 ? 127 TRP B N   1 
ATOM   599  C CA  . TRP A 1 76  ? 8.85300   -12.81900 48.04700  1.000 40.33141 ? 127 TRP B CA  1 
ATOM   600  C C   . TRP A 1 76  ? 9.67800   -11.77800 48.79500  1.000 37.69144 ? 127 TRP B C   1 
ATOM   601  O O   . TRP A 1 76  ? 10.08300  -10.77700 48.24000  1.000 35.18110 ? 127 TRP B O   1 
ATOM   602  C CB  . TRP A 1 76  ? 8.77900   -12.47800 46.55100  1.000 38.62185 ? 127 TRP B CB  1 
ATOM   603  C CG  . TRP A 1 76  ? 7.76400   -13.25000 45.78900  1.000 29.11515 ? 127 TRP B CG  1 
ATOM   604  C CD1 . TRP A 1 76  ? 6.61500   -12.76900 45.25100  1.000 37.76872 ? 127 TRP B CD1 1 
ATOM   605  C CD2 . TRP A 1 76  ? 7.80000   -14.64000 45.47700  1.000 25.08935 ? 127 TRP B CD2 1 
ATOM   606  N NE1 . TRP A 1 76  ? 5.92900   -13.76900 44.62400  1.000 32.35263 ? 127 TRP B NE1 1 
ATOM   607  C CE2 . TRP A 1 76  ? 6.63600   -14.93300 44.74800  1.000 27.95680 ? 127 TRP B CE2 1 
ATOM   608  C CE3 . TRP A 1 76  ? 8.70100   -15.66700 45.74500  1.000 30.76146 ? 127 TRP B CE3 1 
ATOM   609  C CZ2 . TRP A 1 76  ? 6.35200   -16.20500 44.28100  1.000 23.99292 ? 127 TRP B CZ2 1 
ATOM   610  C CZ3 . TRP A 1 76  ? 8.41700   -16.92900 45.28000  1.000 32.44120 ? 127 TRP B CZ3 1 
ATOM   611  C CH2 . TRP A 1 76  ? 7.25300   -17.18900 44.55900  1.000 27.21719 ? 127 TRP B CH2 1 
ATOM   612  N N   . PRO A 1 77  ? 9.94000   -12.04600 50.05700  1.000 37.72719 ? 128 PRO B N   1 
ATOM   613  C CA  . PRO A 1 77  ? 10.69000  -11.09000 50.86900  1.000 47.32676 ? 128 PRO B CA  1 
ATOM   614  C C   . PRO A 1 77  ? 12.13400  -10.94900 50.43100  1.000 41.75109 ? 128 PRO B C   1 
ATOM   615  O O   . PRO A 1 77  ? 12.70800  -9.89400  50.60400  1.000 44.24382 ? 128 PRO B O   1 
ATOM   616  C CB  . PRO A 1 77  ? 10.62000  -11.71600 52.25900  1.000 44.29208 ? 128 PRO B CB  1 
ATOM   617  C CG  . PRO A 1 77  ? 10.43900  -13.17000 52.03100  1.000 38.70075 ? 128 PRO B CG  1 
ATOM   618  C CD  . PRO A 1 77  ? 9.60600   -13.27500 50.79500  1.000 37.50155 ? 128 PRO B CD  1 
ATOM   619  N N   . ASN A 1 78  ? 12.69800  -11.98100 49.84700  1.000 44.16266 ? 129 ASN B N   1 
ATOM   620  C CA  . ASN A 1 78  ? 14.09800  -11.98100 49.46700  1.000 40.31329 ? 129 ASN B CA  1 
ATOM   621  C C   . ASN A 1 78  ? 14.39900  -11.59800 48.03100  1.000 43.49733 ? 129 ASN B C   1 
ATOM   622  O O   . ASN A 1 78  ? 15.54500  -11.65600 47.61100  1.000 38.71896 ? 129 ASN B O   1 
ATOM   623  C CB  . ASN A 1 78  ? 14.60600  -13.38200 49.71700  1.000 38.69975 ? 129 ASN B CB  1 
ATOM   624  C CG  . ASN A 1 78  ? 14.47800  -13.79700 51.16600  1.000 50.90926 ? 129 ASN B CG  1 
ATOM   625  O OD1 . ASN A 1 78  ? 14.37800  -12.95700 52.05400  1.000 44.15195 ? 129 ASN B OD1 1 
ATOM   626  N ND2 . ASN A 1 78  ? 14.48900  -15.10000 51.41200  1.000 50.52230 ? 129 ASN B ND2 1 
ATOM   627  N N   . HIS A 1 79  ? 13.38200  -11.22100 47.27500  1.000 37.02068 ? 130 HIS B N   1 
ATOM   628  C CA  . HIS A 1 79  ? 13.58000  -10.90600 45.88700  1.000 32.79275 ? 130 HIS B CA  1 
ATOM   629  C C   . HIS A 1 79  ? 12.84700  -9.65900  45.49200  1.000 38.56991 ? 130 HIS B C   1 
ATOM   630  O O   . HIS A 1 79  ? 11.88900  -9.28200  46.13400  1.000 42.20276 ? 130 HIS B O   1 
ATOM   631  C CB  . HIS A 1 79  ? 13.10000  -12.06100 45.01000  1.000 33.22080 ? 130 HIS B CB  1 
ATOM   632  C CG  . HIS A 1 79  ? 13.83000  -13.34700 45.21000  1.000 30.37768 ? 130 HIS B CG  1 
ATOM   633  N ND1 . HIS A 1 79  ? 13.41100  -14.30800 46.10100  1.000 31.03721 ? 130 HIS B ND1 1 
ATOM   634  C CD2 . HIS A 1 79  ? 14.92200  -13.85500 44.59400  1.000 29.02599 ? 130 HIS B CD2 1 
ATOM   635  C CE1 . HIS A 1 79  ? 14.23100  -15.34000 46.04800  1.000 39.63214 ? 130 HIS B CE1 1 
ATOM   636  N NE2 . HIS A 1 79  ? 15.15600  -15.09100 45.14100  1.000 34.44525 ? 130 HIS B NE2 1 
ATOM   637  N N   . THR A 1 80  ? 13.30600  -9.00700  44.45000  1.000 37.56035 ? 131 THR B N   1 
ATOM   638  C CA  . THR A 1 80  ? 12.64600  -7.83600  43.94100  1.000 42.71144 ? 131 THR B CA  1 
ATOM   639  C C   . THR A 1 80  ? 11.74900  -8.14900  42.75800  1.000 37.93728 ? 131 THR B C   1 
ATOM   640  O O   . THR A 1 80  ? 11.84900  -9.19700  42.16900  1.000 32.73259 ? 131 THR B O   1 
ATOM   641  C CB  . THR A 1 80  ? 13.66500  -6.79000  43.47700  1.000 37.76706 ? 131 THR B CB  1 
ATOM   642  O OG1 . THR A 1 80  ? 14.46000  -7.32800  42.42400  1.000 51.77056 ? 131 THR B OG1 1 
ATOM   643  C CG2 . THR A 1 80  ? 14.57200  -6.40200  44.62300  1.000 47.00348 ? 131 THR B CG2 1 
ATOM   644  N N   . GLN A 1 81  ? 10.85700  -7.22900  42.44200  1.000 44.84273 ? 132 GLN B N   1 
ATOM   645  C CA  . GLN A 1 81  ? 10.02700  -7.37600  41.24900  1.000 51.00388 ? 132 GLN B CA  1 
ATOM   646  C C   . GLN A 1 81  ? 10.52000  -6.48400  40.11400  1.000 50.64233 ? 132 GLN B C   1 
ATOM   647  O O   . GLN A 1 81  ? 10.57000  -5.27400  40.26300  1.000 52.54638 ? 132 GLN B O   1 
ATOM   648  C CB  . GLN A 1 81  ? 8.57300   -7.04900  41.51100  1.000 40.94942 ? 132 GLN B CB  1 
ATOM   649  C CG  . GLN A 1 81  ? 7.79600   -8.10500  42.28400  1.000 56.06160 ? 132 GLN B CG  1 
ATOM   650  C CD  . GLN A 1 81  ? 8.12800   -8.14100  43.76200  1.000 60.76327 ? 132 GLN B CD  1 
ATOM   651  O OE1 . GLN A 1 81  ? 9.25600   -8.42300  44.14300  1.000 67.86563 ? 132 GLN B OE1 1 
ATOM   652  N NE2 . GLN A 1 81  ? 7.13900   -7.87000  44.60200  1.000 49.44039 ? 132 GLN B NE2 1 
ATOM   653  N N   . ASN A 1 82  ? 10.89200  -7.07600  38.99100  1.000 41.57389 ? 133 ASN B N   1 
ATOM   654  C CA  . ASN A 1 82  ? 11.29000  -6.31000  37.82400  1.000 48.88869 ? 133 ASN B CA  1 
ATOM   655  C C   . ASN A 1 82  ? 10.31500  -5.22400  37.41700  1.000 41.43626 ? 133 ASN B C   1 
ATOM   656  O O   . ASN A 1 82  ? 9.15500   -5.27900  37.76400  1.000 45.61103 ? 133 ASN B O   1 
ATOM   657  C CB  . ASN A 1 82  ? 11.50700  -7.25500  36.62100  1.000 49.16437 ? 133 ASN B CB  1 
ATOM   658  C CG  . ASN A 1 82  ? 12.48900  -6.70800  35.60000  1.000 44.30590 ? 133 ASN B CG  1 
ATOM   659  O OD1 . ASN A 1 82  ? 13.39600  -5.96400  35.93800  1.000 66.19740 ? 133 ASN B OD1 1 
ATOM   660  N ND2 . ASN A 1 82  ? 12.32400  -7.10200  34.34900  1.000 39.71732 ? 133 ASN B ND2 1 
ATOM   661  N N   . GLY A 1 83  ? 10.80900  -4.22600  36.70400  1.000 50.27134 ? 134 GLY B N   1 
ATOM   662  C CA  . GLY A 1 83  ? 9.97100   -3.16300  36.19600  1.000 46.30387 ? 134 GLY B CA  1 
ATOM   663  C C   . GLY A 1 83  ? 9.20900   -3.57800  34.95300  1.000 62.86994 ? 134 GLY B C   1 
ATOM   664  O O   . GLY A 1 83  ? 8.59300   -2.72400  34.31600  1.000 52.92865 ? 134 GLY B O   1 
ATOM   665  N N   . GLY A 1 84  ? 9.24600   -4.86700  34.59000  1.000 44.59231 ? 135 GLY B N   1 
ATOM   666  C CA  . GLY A 1 84  ? 8.47500   -5.35300  33.45700  1.000 36.82703 ? 135 GLY B CA  1 
ATOM   667  C C   . GLY A 1 84  ? 9.02000   -5.04700  32.08300  1.000 48.93955 ? 135 GLY B C   1 
ATOM   668  O O   . GLY A 1 84  ? 10.19600  -5.29900  31.84100  1.000 50.34958 ? 135 GLY B O   1 
ATOM   669  N N   . SER A 1 85  ? 8.19500   -4.52700  31.17700  1.000 35.00019 ? 136 SER B N   1 
ATOM   670  C CA  . SER A 1 85  ? 8.64700   -4.30100  29.82600  1.000 32.15945 ? 136 SER B CA  1 
ATOM   671  C C   . SER A 1 85  ? 7.84800   -3.33500  28.99400  1.000 37.09299 ? 136 SER B C   1 
ATOM   672  O O   . SER A 1 85  ? 6.66100   -3.17300  29.19400  1.000 36.44261 ? 136 SER B O   1 
ATOM   673  C CB  . SER A 1 85  ? 8.68800   -5.62300  29.06600  1.000 30.22769 ? 136 SER B CB  1 
ATOM   674  O OG  . SER A 1 85  ? 9.19400   -5.45600  27.75900  1.000 39.44845 ? 136 SER B OG  1 
ATOM   675  N N   . ASN A 1 86  ? 8.50600   -2.72600  28.03400  1.000 32.61558 ? 137 ASN B N   1 
ATOM   676  C CA  . ASN A 1 86  ? 7.83600   -1.85600  27.09800  1.000 36.91308 ? 137 ASN B CA  1 
ATOM   677  C C   . ASN A 1 86  ? 7.00300   -2.66700  26.12100  1.000 30.78804 ? 137 ASN B C   1 
ATOM   678  O O   . ASN A 1 86  ? 6.06000   -2.16800  25.55400  1.000 28.52045 ? 137 ASN B O   1 
ATOM   679  C CB  . ASN A 1 86  ? 8.87600   -1.05100  26.35000  1.000 35.12481 ? 137 ASN B CB  1 
ATOM   680  C CG  . ASN A 1 86  ? 9.46800   0.06300   27.18800  1.000 48.24844 ? 137 ASN B CG  1 
ATOM   681  O OD1 . ASN A 1 86  ? 8.82800   0.58000   28.09800  1.000 51.68583 ? 137 ASN B OD1 1 
ATOM   682  N ND2 . ASN A 1 86  ? 10.69400  0.44900   26.87200  1.000 58.68266 ? 137 ASN B ND2 1 
ATOM   683  N N   . SER A 1 87  ? 7.38000   -3.91100  25.92100  1.000 29.82855 ? 138 SER B N   1 
ATOM   684  C CA  . SER A 1 87  ? 6.62200   -4.79900  25.07400  1.000 29.69651 ? 138 SER B CA  1 
ATOM   685  C C   . SER A 1 87  ? 5.25500   -5.07800  25.69500  1.000 25.95106 ? 138 SER B C   1 
ATOM   686  O O   . SER A 1 87  ? 4.35100   -5.49600  25.01400  1.000 24.96206 ? 138 SER B O   1 
ATOM   687  C CB  . SER A 1 87  ? 7.43100   -6.06800  24.87000  1.000 24.30835 ? 138 SER B CB  1 
ATOM   688  O OG  . SER A 1 87  ? 8.66300   -5.79000  24.25500  1.000 35.63811 ? 138 SER B OG  1 
ATOM   689  N N   . CYS A 1 88  ? 5.12600   -4.85500  26.98400  1.000 24.07224 ? 139 CYS B N   1 
ATOM   690  C CA  . CYS A 1 88  ? 3.87800   -5.06900  27.69200  1.000 26.84502 ? 139 CYS B CA  1 
ATOM   691  C C   . CYS A 1 88  ? 3.40000   -3.74500  28.30700  1.000 31.73539 ? 139 CYS B C   1 
ATOM   692  O O   . CYS A 1 88  ? 3.16400   -3.64200  29.49300  1.000 27.51411 ? 139 CYS B O   1 
ATOM   693  C CB  . CYS A 1 88  ? 4.07300   -6.17500  28.72900  1.000 26.28359 ? 139 CYS B CB  1 
ATOM   694  S SG  . CYS A 1 88  ? 4.34800   -7.81500  28.06100  1.000 27.76626 ? 139 CYS B SG  1 
ATOM   695  N N   . SER A 1 89  ? 3.22800   -2.75000  27.46300  1.000 31.33467 ? 140 SER B N   1 
ATOM   696  C CA  . SER A 1 89  ? 2.86500   -1.43300  27.93500  1.000 35.58210 ? 140 SER B CA  1 
ATOM   697  C C   . SER A 1 89  ? 1.39500   -1.16500  28.15800  1.000 36.85390 ? 140 SER B C   1 
ATOM   698  O O   . SER A 1 89  ? 0.56100   -1.68300  27.45500  1.000 34.86782 ? 140 SER B O   1 
ATOM   699  C CB  . SER A 1 89  ? 3.44600   -0.39200  26.97600  1.000 33.17089 ? 140 SER B CB  1 
ATOM   700  O OG  . SER A 1 89  ? 4.85200   -0.31800  27.07900  1.000 38.25333 ? 140 SER B OG  1 
ATOM   701  N N   . HIS A 1 90  ? 1.10500   -0.37100  29.17400  1.000 36.32602 ? 141 HIS B N   1 
ATOM   702  C CA  . HIS A 1 90  ? -0.25500  0.02100   29.46300  1.000 46.37182 ? 141 HIS B CA  1 
ATOM   703  C C   . HIS A 1 90  ? -0.26300  1.50100   29.75200  1.000 47.31159 ? 141 HIS B C   1 
ATOM   704  O O   . HIS A 1 90  ? 0.49600   1.98500   30.56200  1.000 43.26904 ? 141 HIS B O   1 
ATOM   705  C CB  . HIS A 1 90  ? -0.81300  -0.74300  30.64500  1.000 43.09487 ? 141 HIS B CB  1 
ATOM   706  C CG  . HIS A 1 90  ? -2.24900  -0.46300  30.92800  1.000 48.76172 ? 141 HIS B CG  1 
ATOM   707  N ND1 . HIS A 1 90  ? -3.25500  -0.78600  30.04800  1.000 52.94855 ? 141 HIS B ND1 1 
ATOM   708  C CD2 . HIS A 1 90  ? -2.85200  0.09300   32.00200  1.000 54.46722 ? 141 HIS B CD2 1 
ATOM   709  C CE1 . HIS A 1 90  ? -4.41700  -0.43300  30.56100  1.000 52.68082 ? 141 HIS B CE1 1 
ATOM   710  N NE2 . HIS A 1 90  ? -4.20000  0.10400   31.74600  1.000 65.50772 ? 141 HIS B NE2 1 
ATOM   711  N N   . ASN A 1 91  ? -1.10700  2.21500   29.04300  1.000 52.17777 ? 142 ASN B N   1 
ATOM   712  C CA  . ASN A 1 91  ? -1.20800  3.64400   29.23900  1.000 58.64277 ? 142 ASN B CA  1 
ATOM   713  C C   . ASN A 1 91  ? 0.13100   4.33400   29.08900  1.000 55.68250 ? 142 ASN B C   1 
ATOM   714  O O   . ASN A 1 91  ? 0.51700   5.09400   29.95500  1.000 64.21829 ? 142 ASN B O   1 
ATOM   715  C CB  . ASN A 1 91  ? -1.82000  3.94100   30.61600  1.000 52.77988 ? 142 ASN B CB  1 
ATOM   716  C CG  . ASN A 1 91  ? -3.27000  3.51600   30.71700  1.000 56.97047 ? 142 ASN B CG  1 
ATOM   717  O OD1 . ASN A 1 91  ? -3.95900  3.38900   29.71400  1.000 60.37498 ? 142 ASN B OD1 1 
ATOM   718  N ND2 . ASN A 1 91  ? -3.74200  3.30800   31.93700  1.000 65.09516 ? 142 ASN B ND2 1 
ATOM   719  N N   . GLY A 1 92  ? 0.85500   4.05600   28.02200  1.000 47.63139 ? 143 GLY B N   1 
ATOM   720  C CA  . GLY A 1 92  ? 2.10100   4.74800   27.77800  1.000 38.88707 ? 143 GLY B CA  1 
ATOM   721  C C   . GLY A 1 92  ? 3.21900   4.45500   28.73800  1.000 51.01786 ? 143 GLY B C   1 
ATOM   722  O O   . GLY A 1 92  ? 4.25700   5.09600   28.69000  1.000 55.57234 ? 143 GLY B O   1 
ATOM   723  N N   . GLU A 1 93  ? 3.02500   3.48300   29.60700  1.000 51.47451 ? 144 GLU B N   1 
ATOM   724  C CA  . GLU A 1 93  ? 4.04600   3.10500   30.55400  1.000 47.37552 ? 144 GLU B CA  1 
ATOM   725  C C   . GLU A 1 93  ? 4.33400   1.62100   30.52300  1.000 51.87271 ? 144 GLU B C   1 
ATOM   726  O O   . GLU A 1 93  ? 3.44800   0.82600   30.26900  1.000 40.74572 ? 144 GLU B O   1 
ATOM   727  C CB  . GLU A 1 93  ? 3.61200   3.46800   31.96400  1.000 43.32772 ? 144 GLU B CB  1 
ATOM   728  C CG  . GLU A 1 93  ? 4.67600   3.26000   33.02500  1.000 66.05078 ? 144 GLU B CG  1 
ATOM   729  C CD  . GLU A 1 93  ? 4.82000   4.45000   33.95700  1.000 78.46787 ? 144 GLU B CD  1 
ATOM   730  O OE1 . GLU A 1 93  ? 4.16700   5.48700   33.71700  1.000 79.91713 ? 144 GLU B OE1 1 
ATOM   731  O OE2 . GLU A 1 93  ? 5.59400   4.35100   34.93200  1.000 78.40649 ? 144 GLU B OE2 1 
ATOM   732  N N   . SER A 1 94  ? 5.57000   1.25700   30.82000  1.000 45.05876 ? 145 SER B N   1 
ATOM   733  C CA  . SER A 1 94  ? 5.95800   -0.11700  30.84300  1.000 37.11433 ? 145 SER B CA  1 
ATOM   734  C C   . SER A 1 94  ? 5.23800   -0.88700  31.93400  1.000 42.57156 ? 145 SER B C   1 
ATOM   735  O O   . SER A 1 94  ? 5.10100   -0.40700  33.04500  1.000 37.26716 ? 145 SER B O   1 
ATOM   736  C CB  . SER A 1 94  ? 7.45400   -0.20200  31.05900  1.000 38.16625 ? 145 SER B CB  1 
ATOM   737  O OG  . SER A 1 94  ? 7.78400   -0.10200  32.42500  1.000 55.28275 ? 145 SER B OG  1 
ATOM   738  N N   . SER A 1 95  ? 4.76000   -2.08400  31.60500  1.000 35.92748 ? 146 SER B N   1 
ATOM   739  C CA  . SER A 1 95  ? 4.11700   -2.92500  32.59700  1.000 28.42134 ? 146 SER B CA  1 
ATOM   740  C C   . SER A 1 95  ? 4.42800   -4.40600  32.37200  1.000 31.15954 ? 146 SER B C   1 
ATOM   741  O O   . SER A 1 95  ? 5.41100   -4.73800  31.74700  1.000 29.55248 ? 146 SER B O   1 
ATOM   742  C CB  . SER A 1 95  ? 2.61000   -2.67800  32.62700  1.000 23.16877 ? 146 SER B CB  1 
ATOM   743  O OG  . SER A 1 95  ? 1.97500   -3.34200  33.70000  1.000 33.49630 ? 146 SER B OG  1 
ATOM   744  N N   . PHE A 1 96  ? 3.58200   -5.27900  32.89300  1.000 23.90467 ? 147 PHE B N   1 
ATOM   745  C CA  . PHE A 1 96  ? 3.76900   -6.71100  32.74700  1.000 31.69905 ? 147 PHE B CA  1 
ATOM   746  C C   . PHE A 1 96  ? 2.46200   -7.45800  32.95500  1.000 29.95936 ? 147 PHE B C   1 
ATOM   747  O O   . PHE A 1 96  ? 1.45000   -6.86000  33.24500  1.000 28.96969 ? 147 PHE B O   1 
ATOM   748  C CB  . PHE A 1 96  ? 4.82900   -7.21800  33.72400  1.000 24.77766 ? 147 PHE B CB  1 
ATOM   749  C CG  . PHE A 1 96  ? 5.41100   -8.55200  33.37800  1.000 21.55265 ? 147 PHE B CG  1 
ATOM   750  C CD1 . PHE A 1 96  ? 6.12000   -8.73300  32.21200  1.000 18.43186 ? 147 PHE B CD1 1 
ATOM   751  C CD2 . PHE A 1 96  ? 5.28100   -9.61500  34.24400  1.000 20.36980 ? 147 PHE B CD2 1 
ATOM   752  C CE1 . PHE A 1 96  ? 6.66600   -9.95500  31.90000  1.000 14.93261 ? 147 PHE B CE1 1 
ATOM   753  C CE2 . PHE A 1 96  ? 5.82700   -10.84200 33.94000  1.000 25.08046 ? 147 PHE B CE2 1 
ATOM   754  C CZ  . PHE A 1 96  ? 6.52100   -11.01200 32.76500  1.000 17.62447 ? 147 PHE B CZ  1 
ATOM   755  N N   . TYR A 1 97  ? 2.49600   -8.75900  32.78000  1.000 23.61454 ? 148 TYR B N   1 
ATOM   756  C CA  . TYR A 1 97  ? 1.33100   -9.56100  32.97500  1.000 22.43073 ? 148 TYR B CA  1 
ATOM   757  C C   . TYR A 1 97  ? 0.82400   -9.45500  34.40500  1.000 28.33994 ? 148 TYR B C   1 
ATOM   758  O O   . TYR A 1 97  ? 1.60000   -9.47000  35.33400  1.000 24.87337 ? 148 TYR B O   1 
ATOM   759  C CB  . TYR A 1 97  ? 1.64100   -11.00900 32.65100  1.000 20.01435 ? 148 TYR B CB  1 
ATOM   760  C CG  . TYR A 1 97  ? 2.11100   -11.30300 31.24600  1.000 19.80828 ? 148 TYR B CG  1 
ATOM   761  C CD1 . TYR A 1 97  ? 1.22500   -11.32000 30.18300  1.000 16.04413 ? 148 TYR B CD1 1 
ATOM   762  C CD2 . TYR A 1 97  ? 3.44000   -11.61200 30.99300  1.000 21.06810 ? 148 TYR B CD2 1 
ATOM   763  C CE1 . TYR A 1 97  ? 1.65300   -11.60900 28.90200  1.000 17.31670 ? 148 TYR B CE1 1 
ATOM   764  C CE2 . TYR A 1 97  ? 3.87800   -11.90300 29.72000  1.000 15.35641 ? 148 TYR B CE2 1 
ATOM   765  C CZ  . TYR A 1 97  ? 2.98200   -11.90000 28.67600  1.000 22.50690 ? 148 TYR B CZ  1 
ATOM   766  O OH  . TYR A 1 97  ? 3.41400   -12.18900 27.40900  1.000 20.25041 ? 148 TYR B OH  1 
ATOM   767  N N   . LYS A 1 98  ? -0.48200  -9.37700  34.56000  1.000 24.81381 ? 149 LYS B N   1 
ATOM   768  C CA  . LYS A 1 98  ? -1.09200  -9.26300  35.88500  1.000 30.16742 ? 149 LYS B CA  1 
ATOM   769  C C   . LYS A 1 98  ? -1.06500  -10.53100 36.70200  1.000 29.88679 ? 149 LYS B C   1 
ATOM   770  O O   . LYS A 1 98  ? -1.02000  -10.46900 37.90500  1.000 33.52481 ? 149 LYS B O   1 
ATOM   771  C CB  . LYS A 1 98  ? -2.52800  -8.78600  35.74000  1.000 28.84386 ? 149 LYS B CB  1 
ATOM   772  C CG  . LYS A 1 98  ? -2.63500  -7.41300  35.09800  1.000 47.12917 ? 149 LYS B CG  1 
ATOM   773  C CD  . LYS A 1 98  ? -4.03900  -7.12600  34.60100  1.000 56.76975 ? 149 LYS B CD  1 
ATOM   774  C CE  . LYS A 1 98  ? -4.07700  -5.86900  33.75200  1.000 53.87099 ? 149 LYS B CE  1 
ATOM   775  N NZ  . LYS A 1 98  ? -3.89400  -4.62500  34.54500  1.000 59.82472 ? 149 LYS B NZ  1 
ATOM   776  N N   . ASN A 1 99  ? -1.06800  -11.67300 36.05000  1.000 21.09066 ? 150 ASN B N   1 
ATOM   777  C CA  . ASN A 1 99  ? -1.12500  -12.93500 36.75400  1.000 24.26732 ? 150 ASN B CA  1 
ATOM   778  C C   . ASN A 1 99  ? 0.24300   -13.54200 37.07800  1.000 24.88453 ? 150 ASN B C   1 
ATOM   779  O O   . ASN A 1 99  ? 0.32900   -14.56000 37.73400  1.000 22.01727 ? 150 ASN B O   1 
ATOM   780  C CB  . ASN A 1 99  ? -1.94200  -13.89000 35.91700  1.000 25.93779 ? 150 ASN B CB  1 
ATOM   781  C CG  . ASN A 1 99  ? -3.34700  -13.38400 35.66600  1.000 31.32888 ? 150 ASN B CG  1 
ATOM   782  O OD1 . ASN A 1 99  ? -3.88100  -12.60200 36.44100  1.000 26.09173 ? 150 ASN B OD1 1 
ATOM   783  N ND2 . ASN A 1 99  ? -3.94900  -13.83400 34.58100  1.000 25.14568 ? 150 ASN B ND2 1 
ATOM   784  N N   . LEU A 1 100 ? 1.29100   -12.89900 36.59600  1.000 23.76699 ? 151 LEU B N   1 
ATOM   785  C CA  . LEU A 1 100 ? 2.64000   -13.38300 36.82800  1.000 25.85352 ? 151 LEU B CA  1 
ATOM   786  C C   . LEU A 1 100 ? 3.50800   -12.32300 37.48300  1.000 26.69599 ? 151 LEU B C   1 
ATOM   787  O O   . LEU A 1 100 ? 3.17100   -11.15300 37.46700  1.000 27.26749 ? 151 LEU B O   1 
ATOM   788  C CB  . LEU A 1 100 ? 3.24900   -13.86300 35.52700  1.000 19.32748 ? 151 LEU B CB  1 
ATOM   789  C CG  . LEU A 1 100 ? 2.55500   -14.94200 34.71200  1.000 22.06424 ? 151 LEU B CG  1 
ATOM   790  C CD1 . LEU A 1 100 ? 3.35900   -15.20800 33.45600  1.000 25.54468 ? 151 LEU B CD1 1 
ATOM   791  C CD2 . LEU A 1 100 ? 2.38300   -16.20800 35.52700  1.000 25.03674 ? 151 LEU B CD2 1 
ATOM   792  N N   . LEU A 1 101 ? 4.61300   -12.74200 38.06400  1.000 29.43696 ? 152 LEU B N   1 
ATOM   793  C CA  . LEU A 1 101 ? 5.50400   -11.82500 38.76200  1.000 30.97449 ? 152 LEU B CA  1 
ATOM   794  C C   . LEU A 1 101 ? 6.95700   -12.05800 38.37100  1.000 25.10061 ? 152 LEU B C   1 
ATOM   795  O O   . LEU A 1 101 ? 7.47900   -13.14200 38.52100  1.000 24.63725 ? 152 LEU B O   1 
ATOM   796  C CB  . LEU A 1 101 ? 5.29800   -11.92000 40.27600  1.000 31.55614 ? 152 LEU B CB  1 
ATOM   797  C CG  . LEU A 1 101 ? 5.63700   -10.72600 41.15600  1.000 38.08604 ? 152 LEU B CG  1 
ATOM   798  C CD1 . LEU A 1 101 ? 4.76800   -9.54200  40.78200  1.000 39.87689 ? 152 LEU B CD1 1 
ATOM   799  C CD2 . LEU A 1 101 ? 5.42400   -11.10100 42.60900  1.000 39.81264 ? 152 LEU B CD2 1 
ATOM   800  N N   . TRP A 1 102 ? 7.56700   -11.03400 37.83200  1.000 21.71433 ? 153 TRP B N   1 
ATOM   801  C CA  . TRP A 1 102 ? 8.92300   -11.13400 37.38800  1.000 24.52564 ? 153 TRP B CA  1 
ATOM   802  C C   . TRP A 1 102 ? 9.87800   -10.87500 38.53700  1.000 24.43632 ? 153 TRP B C   1 
ATOM   803  O O   . TRP A 1 102 ? 10.12100  -9.74900  38.90100  1.000 26.78047 ? 153 TRP B O   1 
ATOM   804  C CB  . TRP A 1 102 ? 9.17100   -10.16000 36.22600  1.000 22.91648 ? 153 TRP B CB  1 
ATOM   805  C CG  . TRP A 1 102 ? 10.42300  -10.44100 35.45600  1.000 26.63963 ? 153 TRP B CG  1 
ATOM   806  C CD1 . TRP A 1 102 ? 11.53900  -11.06100 35.91600  1.000 22.98492 ? 153 TRP B CD1 1 
ATOM   807  C CD2 . TRP A 1 102 ? 10.68500  -10.10800 34.08800  1.000 20.15499 ? 153 TRP B CD2 1 
ATOM   808  N NE1 . TRP A 1 102 ? 12.47800  -11.14000 34.92700  1.000 26.82884 ? 153 TRP B NE1 1 
ATOM   809  C CE2 . TRP A 1 102 ? 11.97900  -10.56400 33.79200  1.000 19.76211 ? 153 TRP B CE2 1 
ATOM   810  C CE3 . TRP A 1 102 ? 9.94900   -9.47500  33.08500  1.000 22.21334 ? 153 TRP B CE3 1 
ATOM   811  C CZ2 . TRP A 1 102 ? 12.55600  -10.40700 32.53800  1.000 21.08455 ? 153 TRP B CZ2 1 
ATOM   812  C CZ3 . TRP A 1 102 ? 10.52300  -9.31800  31.84300  1.000 26.04986 ? 153 TRP B CZ3 1 
ATOM   813  C CH2 . TRP A 1 102 ? 11.81500  -9.77900  31.57900  1.000 21.54691 ? 153 TRP B CH2 1 
ATOM   814  N N   . LEU A 1 103 ? 10.40300  -11.94200 39.09200  1.000 24.57250 ? 154 LEU B N   1 
ATOM   815  C CA  . LEU A 1 103 ? 11.33200  -11.81500 40.18700  1.000 23.94064 ? 154 LEU B CA  1 
ATOM   816  C C   . LEU A 1 103 ? 12.72900  -11.49000 39.71700  1.000 33.15438 ? 154 LEU B C   1 
ATOM   817  O O   . LEU A 1 103 ? 13.19500  -12.03300 38.72700  1.000 30.22570 ? 154 LEU B O   1 
ATOM   818  C CB  . LEU A 1 103 ? 11.33400  -13.09600 41.00500  1.000 27.61417 ? 154 LEU B CB  1 
ATOM   819  C CG  . LEU A 1 103 ? 10.04600  -13.40400 41.76000  1.000 29.65591 ? 154 LEU B CG  1 
ATOM   820  C CD1 . LEU A 1 103 ? 10.16800  -14.70900 42.52500  1.000 25.35827 ? 154 LEU B CD1 1 
ATOM   821  C CD2 . LEU A 1 103 ? 9.72700   -12.25300 42.69400  1.000 31.76759 ? 154 LEU B CD2 1 
ATOM   822  N N   . THR A 1 104 ? 13.38900  -10.60300 40.43100  1.000 28.06027 ? 155 THR B N   1 
ATOM   823  C CA  . THR A 1 104 ? 14.72500  -10.20600 40.09200  1.000 26.70408 ? 155 THR B CA  1 
ATOM   824  C C   . THR A 1 104 ? 15.61000  -10.20600 41.34900  1.000 33.98322 ? 155 THR B C   1 
ATOM   825  O O   . THR A 1 104 ? 15.12800  -10.40800 42.45000  1.000 32.22939 ? 155 THR B O   1 
ATOM   826  C CB  . THR A 1 104 ? 14.74900  -8.81800  39.42900  1.000 27.19645 ? 155 THR B CB  1 
ATOM   827  O OG1 . THR A 1 104 ? 13.85200  -7.93400  40.10100  1.000 33.91964 ? 155 THR B OG1 1 
ATOM   828  C CG2 . THR A 1 104 ? 14.33800  -8.93500  37.97500  1.000 37.31992 ? 155 THR B CG2 1 
ATOM   829  N N   . LYS A 1 105 ? 16.89200  -9.99200  41.16600  1.000 26.30115 ? 156 LYS B N   1 
ATOM   830  C CA  . LYS A 1 105 ? 17.80800  -9.93600  42.28900  1.000 36.80548 ? 156 LYS B CA  1 
ATOM   831  C C   . LYS A 1 105 ? 17.48200  -8.89200  43.35700  1.000 36.44532 ? 156 LYS B C   1 
ATOM   832  O O   . LYS A 1 105 ? 16.93200  -7.85100  43.06900  1.000 31.10560 ? 156 LYS B O   1 
ATOM   833  C CB  . LYS A 1 105 ? 19.23800  -9.65700  41.78800  1.000 31.46389 ? 156 LYS B CB  1 
ATOM   834  C CG  . LYS A 1 105 ? 19.44200  -8.24600  41.29100  1.000 30.54836 ? 156 LYS B CG  1 
ATOM   835  C CD  . LYS A 1 105 ? 20.87500  -7.99100  40.88500  1.000 32.80637 ? 156 LYS B CD  1 
ATOM   836  C CE  . LYS A 1 105 ? 21.03100  -6.55900  40.41700  1.000 35.35725 ? 156 LYS B CE  1 
ATOM   837  N NZ  . LYS A 1 105 ? 22.25900  -6.36100  39.61000  1.000 38.94483 ? 156 LYS B NZ  1 
ATOM   838  N N   . SER A 1 106 ? 17.84300  -9.18600  44.58600  1.000 39.72102 ? 157 SER B N   1 
ATOM   839  C CA  . SER A 1 106 ? 17.70000  -8.21400  45.66800  1.000 43.17083 ? 157 SER B CA  1 
ATOM   840  C C   . SER A 1 106 ? 19.10200  -7.90300  46.18000  1.000 36.41832 ? 157 SER B C   1 
ATOM   841  O O   . SER A 1 106 ? 19.68700  -8.69100  46.92900  1.000 35.46929 ? 157 SER B O   1 
ATOM   842  C CB  . SER A 1 106 ? 16.80100  -8.74600  46.78000  1.000 41.50006 ? 157 SER B CB  1 
ATOM   843  O OG  . SER A 1 106 ? 16.46300  -7.71900  47.69500  1.000 50.15890 ? 157 SER B OG  1 
ATOM   844  N N   . GLY A 1 107 ? 19.64000  -6.76200  45.77100  1.000 40.30234 ? 158 GLY B N   1 
ATOM   845  C CA  . GLY A 1 107 ? 21.00400  -6.42000  46.14100  1.000 39.76373 ? 158 GLY B CA  1 
ATOM   846  C C   . GLY A 1 107 ? 21.98900  -7.10200  45.22100  1.000 41.43810 ? 158 GLY B C   1 
ATOM   847  O O   . GLY A 1 107 ? 21.87100  -7.02200  43.99600  1.000 43.23726 ? 158 GLY B O   1 
ATOM   848  N N   . SER A 1 108 ? 22.96800  -7.78600  45.80900  1.000 39.75768 ? 159 SER B N   1 
ATOM   849  C CA  . SER A 1 108 ? 24.00000  -8.47700  45.04900  1.000 43.07775 ? 159 SER B CA  1 
ATOM   850  C C   . SER A 1 108 ? 23.72400  -9.96800  44.90100  1.000 37.41364 ? 159 SER B C   1 
ATOM   851  O O   . SER A 1 108 ? 24.60900  -10.70800 44.45800  1.000 38.65158 ? 159 SER B O   1 
ATOM   852  C CB  . SER A 1 108 ? 25.36800  -8.26300  45.70200  1.000 43.70397 ? 159 SER B CB  1 
ATOM   853  O OG  . SER A 1 108 ? 25.41000  -8.83200  47.00000  1.000 36.76799 ? 159 SER B OG  1 
ATOM   854  N N   . LEU A 1 109 ? 22.52900  -10.39300 45.26800  1.000 32.96484 ? 160 LEU B N   1 
ATOM   855  C CA  . LEU A 1 109 ? 22.15900  -11.78200 45.13900  1.000 36.13355 ? 160 LEU B CA  1 
ATOM   856  C C   . LEU A 1 109 ? 20.71600  -12.07600 44.72800  1.000 46.16615 ? 160 LEU B C   1 
ATOM   857  O O   . LEU A 1 109 ? 19.81100  -11.30600 45.02300  1.000 37.53223 ? 160 LEU B O   1 
ATOM   858  C CB  . LEU A 1 109 ? 22.41100  -12.49100 46.45200  1.000 33.92200 ? 160 LEU B CB  1 
ATOM   859  C CG  . LEU A 1 109 ? 23.84000  -12.73800 46.91300  1.000 48.39023 ? 160 LEU B CG  1 
ATOM   860  C CD1 . LEU A 1 109 ? 23.81000  -13.35100 48.30200  1.000 44.73376 ? 160 LEU B CD1 1 
ATOM   861  C CD2 . LEU A 1 109 ? 24.54400  -13.66000 45.93300  1.000 48.86104 ? 160 LEU B CD2 1 
ATOM   862  N N   . TYR A 1 110 ? 20.51300  -13.18200 44.02400  1.000 37.95794 ? 161 TYR B N   1 
ATOM   863  C CA  . TYR A 1 110 ? 19.19000  -13.63200 43.71000  1.000 34.44930 ? 161 TYR B CA  1 
ATOM   864  C C   . TYR A 1 110 ? 19.14100  -14.91100 44.50500  1.000 36.31887 ? 161 TYR B C   1 
ATOM   865  O O   . TYR A 1 110 ? 19.59000  -15.95100 44.05900  1.000 34.75674 ? 161 TYR B O   1 
ATOM   866  C CB  . TYR A 1 110 ? 18.99900  -13.88600 42.22800  1.000 31.36825 ? 161 TYR B CB  1 
ATOM   867  C CG  . TYR A 1 110 ? 17.63900  -14.42400 41.83900  1.000 30.94566 ? 161 TYR B CG  1 
ATOM   868  C CD1 . TYR A 1 110 ? 17.22200  -15.67700 42.25100  1.000 24.86989 ? 161 TYR B CD1 1 
ATOM   869  C CD2 . TYR A 1 110 ? 16.78600  -13.68700 41.02900  1.000 30.88642 ? 161 TYR B CD2 1 
ATOM   870  C CE1 . TYR A 1 110 ? 15.99500  -16.17600 41.88800  1.000 27.51887 ? 161 TYR B CE1 1 
ATOM   871  C CE2 . TYR A 1 110 ? 15.55300  -14.17800 40.65700  1.000 22.85828 ? 161 TYR B CE2 1 
ATOM   872  C CZ  . TYR A 1 110 ? 15.16300  -15.42500 41.08800  1.000 32.53855 ? 161 TYR B CZ  1 
ATOM   873  O OH  . TYR A 1 110 ? 13.94200  -15.92700 40.72500  1.000 30.66226 ? 161 TYR B OH  1 
ATOM   874  N N   . PRO A 1 111 ? 18.58100  -14.83700 45.70000  1.000 37.23879 ? 162 PRO B N   1 
ATOM   875  C CA  . PRO A 1 111 ? 18.62100  -16.01800 46.55600  1.000 33.59423 ? 162 PRO B CA  1 
ATOM   876  C C   . PRO A 1 111 ? 17.81500  -17.20000 46.04000  1.000 39.07276 ? 162 PRO B C   1 
ATOM   877  O O   . PRO A 1 111 ? 16.89300  -17.03300 45.25900  1.000 37.99937 ? 162 PRO B O   1 
ATOM   878  C CB  . PRO A 1 111 ? 18.05100  -15.50400 47.88000  1.000 31.41204 ? 162 PRO B CB  1 
ATOM   879  C CG  . PRO A 1 111 ? 18.08000  -14.01800 47.80100  1.000 38.24069 ? 162 PRO B CG  1 
ATOM   880  C CD  . PRO A 1 111 ? 17.95800  -13.68000 46.35400  1.000 36.07744 ? 162 PRO B CD  1 
ATOM   881  N N   . ASN A 1 112 ? 18.18500  -18.39000 46.46300  1.000 31.30240 ? 163 ASN B N   1 
ATOM   882  C CA  . ASN A 1 112 ? 17.42600  -19.56700 46.08100  1.000 38.20566 ? 163 ASN B CA  1 
ATOM   883  C C   . ASN A 1 112 ? 16.02100  -19.45700 46.61400  1.000 42.24347 ? 163 ASN B C   1 
ATOM   884  O O   . ASN A 1 112 ? 15.80600  -18.91200 47.68300  1.000 35.04661 ? 163 ASN B O   1 
ATOM   885  C CB  . ASN A 1 112 ? 18.06600  -20.85600 46.60200  1.000 40.59412 ? 163 ASN B CB  1 
ATOM   886  C CG  . ASN A 1 112 ? 19.23800  -21.31000 45.76500  1.000 52.45349 ? 163 ASN B CG  1 
ATOM   887  O OD1 . ASN A 1 112 ? 19.95800  -20.50000 45.19100  1.000 56.64097 ? 163 ASN B OD1 1 
ATOM   888  N ND2 . ASN A 1 112 ? 19.43900  -22.61600 45.69800  1.000 50.12763 ? 163 ASN B ND2 1 
ATOM   889  N N   . LEU A 1 113 ? 15.06800  -19.98700 45.87000  1.000 35.36224 ? 164 LEU B N   1 
ATOM   890  C CA  . LEU A 1 113 ? 13.69000  -19.89200 46.28100  1.000 29.84765 ? 164 LEU B CA  1 
ATOM   891  C C   . LEU A 1 113 ? 12.97500  -21.21000 46.27000  1.000 31.69260 ? 164 LEU B C   1 
ATOM   892  O O   . LEU A 1 113 ? 13.23900  -22.04500 45.42900  1.000 37.51411 ? 164 LEU B O   1 
ATOM   893  C CB  . LEU A 1 113 ? 12.96500  -18.87900 45.40000  1.000 38.09383 ? 164 LEU B CB  1 
ATOM   894  C CG  . LEU A 1 113 ? 12.66200  -19.17300 43.93500  1.000 40.27251 ? 164 LEU B CG  1 
ATOM   895  C CD1 . LEU A 1 113 ? 11.40400  -20.01200 43.80500  1.000 33.09867 ? 164 LEU B CD1 1 
ATOM   896  C CD2 . LEU A 1 113 ? 12.48300  -17.85400 43.21000  1.000 38.38064 ? 164 LEU B CD2 1 
ATOM   897  N N   . SER A 1 114 ? 12.08400  -21.40800 47.22600  1.000 34.24983 ? 165 SER B N   1 
ATOM   898  C CA  . SER A 1 114 ? 11.27000  -22.60500 47.27500  1.000 40.07480 ? 165 SER B CA  1 
ATOM   899  C C   . SER A 1 114 ? 9.92000   -22.16900 47.74300  1.000 43.84418 ? 165 SER B C   1 
ATOM   900  O O   . SER A 1 114 ? 9.76600   -21.72400 48.86300  1.000 46.13466 ? 165 SER B O   1 
ATOM   901  C CB  . SER A 1 114 ? 11.82600  -23.66900 48.20300  1.000 32.66106 ? 165 SER B CB  1 
ATOM   902  O OG  . SER A 1 114 ? 10.96500  -24.77900 48.26100  1.000 48.27829 ? 165 SER B OG  1 
ATOM   903  N N   . LYS A 1 115 ? 8.94500   -22.24500 46.86900  1.000 38.76234 ? 166 LYS B N   1 
ATOM   904  C CA  . LYS A 1 115 ? 7.58000   -21.90100 47.23600  1.000 42.49356 ? 166 LYS B CA  1 
ATOM   905  C C   . LYS A 1 115 ? 6.65100   -23.03400 46.83400  1.000 48.79775 ? 166 LYS B C   1 
ATOM   906  O O   . LYS A 1 115 ? 6.75500   -23.57200 45.72700  1.000 43.32106 ? 166 LYS B O   1 
ATOM   907  C CB  . LYS A 1 115 ? 7.13700   -20.59200 46.57600  1.000 39.52942 ? 166 LYS B CB  1 
ATOM   908  C CG  . LYS A 1 115 ? 6.28100   -19.71600 47.47000  1.000 47.43172 ? 166 LYS B CG  1 
ATOM   909  C CD  . LYS A 1 115 ? 7.11600   -19.07500 48.56900  1.000 51.11409 ? 166 LYS B CD  1 
ATOM   910  C CE  . LYS A 1 115 ? 6.37800   -17.91900 49.22400  1.000 51.39050 ? 166 LYS B CE  1 
ATOM   911  N NZ  . LYS A 1 115 ? 4.93900   -18.22300 49.44500  1.000 50.05896 ? 166 LYS B NZ  1 
ATOM   912  N N   . SER A 1 116 ? 5.74300   -23.39200 47.73800  1.000 43.80231 ? 167 SER B N   1 
ATOM   913  C CA  A SER A 1 116 ? 4.81500   -24.48900 47.52000  0.556 40.74013 ? 167 SER B CA  1 
ATOM   914  C CA  B SER A 1 116 ? 4.81400   -24.48800 47.51700  0.444 40.74361 ? 167 SER B CA  1 
ATOM   915  C C   . SER A 1 116 ? 3.39000   -24.01600 47.76900  1.000 36.13129 ? 167 SER B C   1 
ATOM   916  O O   . SER A 1 116 ? 3.15000   -23.04500 48.49100  1.000 41.46499 ? 167 SER B O   1 
ATOM   917  C CB  A SER A 1 116 ? 5.13600   -25.68500 48.42700  0.556 42.04743 ? 167 SER B CB  1 
ATOM   918  C CB  B SER A 1 116 ? 5.13600   -25.69000 48.41600  0.444 42.04432 ? 167 SER B CB  1 
ATOM   919  O OG  A SER A 1 116 ? 5.09700   -25.31100 49.79400  0.556 45.33402 ? 167 SER B OG  1 
ATOM   920  O OG  B SER A 1 116 ? 6.43200   -26.19600 48.14500  0.444 40.75469 ? 167 SER B OG  1 
ATOM   921  N N   . TYR A 1 117 ? 2.44300   -24.72300 47.15600  1.000 37.34374 ? 168 TYR B N   1 
ATOM   922  C CA  . TYR A 1 117 ? 1.02400   -24.44100 47.32000  1.000 41.60199 ? 168 TYR B CA  1 
ATOM   923  C C   . TYR A 1 117 ? 0.26100   -25.75400 47.35000  1.000 43.76686 ? 168 TYR B C   1 
ATOM   924  O O   . TYR A 1 117 ? 0.43700   -26.59600 46.46400  1.000 44.54254 ? 168 TYR B O   1 
ATOM   925  C CB  . TYR A 1 117 ? 0.48800   -23.55100 46.19200  1.000 38.19526 ? 168 TYR B CB  1 
ATOM   926  C CG  . TYR A 1 117 ? -1.02300  -23.49700 46.13500  1.000 43.28399 ? 168 TYR B CG  1 
ATOM   927  C CD1 . TYR A 1 117 ? -1.73600  -22.64600 46.96900  1.000 47.32877 ? 168 TYR B CD1 1 
ATOM   928  C CD2 . TYR A 1 117 ? -1.73600  -24.29800 45.25200  1.000 42.15176 ? 168 TYR B CD2 1 
ATOM   929  C CE1 . TYR A 1 117 ? -3.11600  -22.59400 46.92500  1.000 46.09355 ? 168 TYR B CE1 1 
ATOM   930  C CE2 . TYR A 1 117 ? -3.11700  -24.25300 45.20200  1.000 45.62525 ? 168 TYR B CE2 1 
ATOM   931  C CZ  . TYR A 1 117 ? -3.80100  -23.39900 46.04000  1.000 42.30746 ? 168 TYR B CZ  1 
ATOM   932  O OH  . TYR A 1 117 ? -5.17600  -23.34800 45.99400  1.000 55.64952 ? 168 TYR B OH  1 
ATOM   933  N N   . ALA A 1 118 ? -0.58500  -25.92200 48.36000  1.000 46.64357 ? 169 ALA B N   1 
ATOM   934  C CA  . ALA A 1 118 ? -1.45500  -27.08400 48.46800  1.000 53.75397 ? 169 ALA B CA  1 
ATOM   935  C C   . ALA A 1 118 ? -2.85400  -26.70700 48.00000  1.000 47.03846 ? 169 ALA B C   1 
ATOM   936  O O   . ALA A 1 118 ? -3.39300  -25.67300 48.40900  1.000 41.41229 ? 169 ALA B O   1 
ATOM   937  C CB  . ALA A 1 118 ? -1.49700  -27.60500 49.90500  1.000 51.95405 ? 169 ALA B CB  1 
ATOM   938  N N   . ASN A 1 119 ? -3.43400  -27.54000 47.13700  1.000 43.44355 ? 170 ASN B N   1 
ATOM   939  C CA  . ASN A 1 119 ? -4.78200  -27.28900 46.64400  1.000 50.07453 ? 170 ASN B CA  1 
ATOM   940  C C   . ASN A 1 119 ? -5.80100  -27.53500 47.75000  1.000 54.34390 ? 170 ASN B C   1 
ATOM   941  O O   . ASN A 1 119 ? -6.33700  -28.64100 47.87700  1.000 44.75029 ? 170 ASN B O   1 
ATOM   942  C CB  . ASN A 1 119 ? -5.08500  -28.16400 45.42600  1.000 46.59884 ? 170 ASN B CB  1 
ATOM   943  C CG  . ASN A 1 119 ? -6.28800  -27.67400 44.64000  1.000 51.25243 ? 170 ASN B CG  1 
ATOM   944  O OD1 . ASN A 1 119 ? -7.00200  -26.76900 45.07400  1.000 51.30340 ? 170 ASN B OD1 1 
ATOM   945  N ND2 . ASN A 1 119 ? -6.51400  -28.26600 43.47300  1.000 46.37163 ? 170 ASN B ND2 1 
ATOM   946  N N   . ASN A 1 120 ? -6.06900  -26.50600 48.55700  1.000 60.12808 ? 171 ASN B N   1 
ATOM   947  C CA  . ASN A 1 120 ? -7.02500  -26.65100 49.64800  1.000 52.20215 ? 171 ASN B CA  1 
ATOM   948  C C   . ASN A 1 120 ? -8.45900  -26.68900 49.13700  1.000 64.51589 ? 171 ASN B C   1 
ATOM   949  O O   . ASN A 1 120 ? -9.33700  -27.25200 49.80000  1.000 70.88360 ? 171 ASN B O   1 
ATOM   950  C CB  . ASN A 1 120 ? -6.84400  -25.51300 50.65300  1.000 47.43658 ? 171 ASN B CB  1 
ATOM   951  C CG  . ASN A 1 120 ? -7.44200  -24.20800 50.16900  1.000 63.62983 ? 171 ASN B CG  1 
ATOM   952  O OD1 . ASN A 1 120 ? -6.84400  -23.49900 49.36000  1.000 62.13451 ? 171 ASN B OD1 1 
ATOM   953  N ND2 . ASN A 1 120 ? -8.62700  -23.88100 50.66900  1.000 72.31438 ? 171 ASN B ND2 1 
ATOM   954  N N   . LYS A 1 121 ? -8.71600  -26.10200 47.97200  1.000 61.29518 ? 172 LYS B N   1 
ATOM   955  C CA  . LYS A 1 121 ? -10.05400 -26.11700 47.40400  1.000 62.03220 ? 172 LYS B CA  1 
ATOM   956  C C   . LYS A 1 121 ? -10.40400 -27.51300 46.89500  1.000 67.36534 ? 172 LYS B C   1 
ATOM   957  O O   . LYS A 1 121 ? -9.54000  -28.37600 46.71200  1.000 69.75404 ? 172 LYS B O   1 
ATOM   958  C CB  . LYS A 1 121 ? -10.16500 -25.10000 46.26800  1.000 57.89073 ? 172 LYS B CB  1 
ATOM   959  C CG  . LYS A 1 121 ? -9.50400  -23.76500 46.56600  1.000 58.57856 ? 172 LYS B CG  1 
ATOM   960  C CD  . LYS A 1 121 ? -9.86400  -22.72900 45.51600  1.000 61.54744 ? 172 LYS B CD  1 
ATOM   961  C CE  . LYS A 1 121 ? -10.40300 -21.45600 46.14600  1.000 62.44927 ? 172 LYS B CE  1 
ATOM   962  N NZ  . LYS A 1 121 ? -9.38100  -20.77900 46.99000  1.000 60.46743 ? 172 LYS B NZ  1 
ATOM   963  N N   . GLU A 1 122 ? -11.69900 -27.72900 46.66900  1.000 64.28016 ? 173 GLU B N   1 
ATOM   964  C CA  . GLU A 1 122 ? -12.20100 -28.99100 46.14600  1.000 67.96685 ? 173 GLU B CA  1 
ATOM   965  C C   . GLU A 1 122 ? -12.33500 -28.97900 44.62700  1.000 66.06596 ? 173 GLU B C   1 
ATOM   966  O O   . GLU A 1 122 ? -13.04200 -29.82500 44.06600  1.000 59.55792 ? 173 GLU B O   1 
ATOM   967  C CB  . GLU A 1 122 ? -13.54100 -29.33400 46.79900  1.000 72.09990 ? 173 GLU B CB  1 
ATOM   968  C CG  . GLU A 1 122 ? -13.41500 -29.81300 48.23800  1.000 81.98893 ? 173 GLU B CG  1 
ATOM   969  C CD  . GLU A 1 122 ? -14.43300 -29.17300 49.16100  1.000 90.77583 ? 173 GLU B CD  1 
ATOM   970  O OE1 . GLU A 1 122 ? -15.57900 -29.66600 49.21800  1.000 93.69447 ? 173 GLU B OE1 1 
ATOM   971  O OE2 . GLU A 1 122 ? -14.08500 -28.17700 49.83000  1.000 84.21847 ? 173 GLU B OE2 1 
ATOM   972  N N   . LYS A 1 123 ? -11.67200 -28.04100 43.95600  1.000 63.25798 ? 174 LYS B N   1 
ATOM   973  C CA  . LYS A 1 123 ? -11.69100 -27.92100 42.50700  1.000 53.30798 ? 174 LYS B CA  1 
ATOM   974  C C   . LYS A 1 123 ? -10.26000 -27.94100 41.98900  1.000 44.89751 ? 174 LYS B C   1 
ATOM   975  O O   . LYS A 1 123 ? -9.29800  -27.77200 42.74500  1.000 43.34323 ? 174 LYS B O   1 
ATOM   976  C CB  . LYS A 1 123 ? -12.40200 -26.63300 42.06500  1.000 45.54932 ? 174 LYS B CB  1 
ATOM   977  C CG  . LYS A 1 123 ? -13.35100 -26.06000 43.10700  1.000 52.64654 ? 174 LYS B CG  1 
ATOM   978  C CD  . LYS A 1 123 ? -14.19100 -24.92600 42.54200  1.000 58.97222 ? 174 LYS B CD  1 
ATOM   979  C CE  . LYS A 1 123 ? -13.60200 -23.57500 42.91100  1.000 55.66329 ? 174 LYS B CE  1 
ATOM   980  N NZ  . LYS A 1 123 ? -14.30600 -22.45200 42.23400  1.000 55.07083 ? 174 LYS B NZ  1 
ATOM   981  N N   . GLU A 1 124 ? -10.12100 -28.15000 40.68400  1.000 48.19642 ? 175 GLU B N   1 
ATOM   982  C CA  . GLU A 1 124 ? -8.80500  -28.10600 40.06600  1.000 44.91381 ? 175 GLU B CA  1 
ATOM   983  C C   . GLU A 1 124 ? -8.32600  -26.66400 39.94500  1.000 40.85636 ? 175 GLU B C   1 
ATOM   984  O O   . GLU A 1 124 ? -9.11700  -25.73500 39.76400  1.000 38.08500 ? 175 GLU B O   1 
ATOM   985  C CB  . GLU A 1 124 ? -8.83500  -28.76900 38.69000  1.000 45.02746 ? 175 GLU B CB  1 
ATOM   986  C CG  . GLU A 1 124 ? -8.50000  -30.25200 38.71400  1.000 52.45289 ? 175 GLU B CG  1 
ATOM   987  C CD  . GLU A 1 124 ? -8.34800  -30.84000 37.32700  1.000 56.88713 ? 175 GLU B CD  1 
ATOM   988  O OE1 . GLU A 1 124 ? -9.00600  -30.33700 36.39100  1.000 62.73647 ? 175 GLU B OE1 1 
ATOM   989  O OE2 . GLU A 1 124 ? -7.57200  -31.80600 37.17300  1.000 65.97464 ? 175 GLU B OE2 1 
ATOM   990  N N   . VAL A 1 125 ? -7.01300  -26.48000 40.05300  1.000 34.58455 ? 176 VAL B N   1 
ATOM   991  C CA  . VAL A 1 125 ? -6.39400  -25.15900 40.02600  1.000 41.08144 ? 176 VAL B CA  1 
ATOM   992  C C   . VAL A 1 125 ? -5.46200  -25.08900 38.82500  1.000 47.82886 ? 176 VAL B C   1 
ATOM   993  O O   . VAL A 1 125 ? -4.55900  -25.92200 38.68200  1.000 39.32014 ? 176 VAL B O   1 
ATOM   994  C CB  . VAL A 1 125 ? -5.63200  -24.85700 41.32600  1.000 38.07336 ? 176 VAL B CB  1 
ATOM   995  C CG1 . VAL A 1 125 ? -4.85200  -23.55700 41.19500  1.000 33.30403 ? 176 VAL B CG1 1 
ATOM   996  C CG2 . VAL A 1 125 ? -6.59500  -24.78800 42.49800  1.000 39.78478 ? 176 VAL B CG2 1 
ATOM   997  N N   . LEU A 1 126 ? -5.68000  -24.09500 37.96600  1.000 31.20763 ? 177 LEU B N   1 
ATOM   998  C CA  . LEU A 1 126 ? -4.81900  -23.85200 36.81400  1.000 34.15688 ? 177 LEU B CA  1 
ATOM   999  C C   . LEU A 1 126 ? -3.69100  -22.92100 37.24500  1.000 26.12919 ? 177 LEU B C   1 
ATOM   1000 O O   . LEU A 1 126 ? -3.93200  -21.75900 37.58500  1.000 29.62330 ? 177 LEU B O   1 
ATOM   1001 C CB  . LEU A 1 126 ? -5.61400  -23.25100 35.65800  1.000 34.67457 ? 177 LEU B CB  1 
ATOM   1002 C CG  . LEU A 1 126 ? -4.79000  -22.72200 34.48100  1.000 34.95254 ? 177 LEU B CG  1 
ATOM   1003 C CD1 . LEU A 1 126 ? -3.97600  -23.84300 33.84400  1.000 19.84432 ? 177 LEU B CD1 1 
ATOM   1004 C CD2 . LEU A 1 126 ? -5.68200  -22.04300 33.45200  1.000 25.33481 ? 177 LEU B CD2 1 
ATOM   1005 N N   . VAL A 1 127 ? -2.46200  -23.43100 37.23300  1.000 28.37363 ? 178 VAL B N   1 
ATOM   1006 C CA  . VAL A 1 127 ? -1.27900  -22.66800 37.61300  1.000 29.75978 ? 178 VAL B CA  1 
ATOM   1007 C C   . VAL A 1 127 ? -0.47100  -22.38500 36.35500  1.000 28.49534 ? 178 VAL B C   1 
ATOM   1008 O O   . VAL A 1 127 ? -0.22100  -23.29400 35.55500  1.000 25.23761 ? 178 VAL B O   1 
ATOM   1009 C CB  . VAL A 1 127 ? -0.43000  -23.42000 38.65200  1.000 25.18214 ? 178 VAL B CB  1 
ATOM   1010 C CG1 . VAL A 1 127 ? 0.66200   -22.51400 39.20300  1.000 20.46627 ? 178 VAL B CG1 1 
ATOM   1011 C CG2 . VAL A 1 127 ? -1.31000  -23.95500 39.77000  1.000 34.53197 ? 178 VAL B CG2 1 
ATOM   1012 N N   . LEU A 1 128 ? -0.05100  -21.14700 36.22000  1.000 24.33650 ? 179 LEU B N   1 
ATOM   1013 C CA  . LEU A 1 128 ? 0.75500   -20.74100 35.09000  1.000 22.92920 ? 179 LEU B CA  1 
ATOM   1014 C C   . LEU A 1 128 ? 2.03000   -20.04400 35.53900  1.000 22.86064 ? 179 LEU B C   1 
ATOM   1015 O O   . LEU A 1 128 ? 2.05200   -19.36700 36.54800  1.000 24.06004 ? 179 LEU B O   1 
ATOM   1016 C CB  . LEU A 1 128 ? -0.02200  -19.84400 34.15200  1.000 18.28628 ? 179 LEU B CB  1 
ATOM   1017 C CG  . LEU A 1 128 ? -1.33500  -20.31600 33.52700  1.000 25.38227 ? 179 LEU B CG  1 
ATOM   1018 C CD1 . LEU A 1 128 ? -2.50000  -19.58600 34.16300  1.000 24.86830 ? 179 LEU B CD1 1 
ATOM   1019 C CD2 . LEU A 1 128 ? -1.33200  -20.08400 32.02700  1.000 22.07504 ? 179 LEU B CD2 1 
ATOM   1020 N N   . TRP A 1 129 ? 3.07600   -20.22100 34.76800  1.000 20.09356 ? 180 TRP B N   1 
ATOM   1021 C CA  . TRP A 1 129 ? 4.35200   -19.62900 35.08400  1.000 21.90078 ? 180 TRP B CA  1 
ATOM   1022 C C   . TRP A 1 129 ? 5.20000   -19.48900 33.84000  1.000 21.96963 ? 180 TRP B C   1 
ATOM   1023 O O   . TRP A 1 129 ? 4.83400   -19.96100 32.78400  1.000 17.36945 ? 180 TRP B O   1 
ATOM   1024 C CB  . TRP A 1 129 ? 5.11600   -20.46000 36.10900  1.000 17.91098 ? 180 TRP B CB  1 
ATOM   1025 C CG  . TRP A 1 129 ? 5.62400   -21.75900 35.62300  1.000 19.81444 ? 180 TRP B CG  1 
ATOM   1026 C CD1 . TRP A 1 129 ? 6.86000   -22.01700 35.12700  1.000 21.21804 ? 180 TRP B CD1 1 
ATOM   1027 C CD2 . TRP A 1 129 ? 4.91700   -22.99800 35.60400  1.000 21.60485 ? 180 TRP B CD2 1 
ATOM   1028 N NE1 . TRP A 1 129 ? 6.96800   -23.33700 34.78700  1.000 22.56329 ? 180 TRP B NE1 1 
ATOM   1029 C CE2 . TRP A 1 129 ? 5.78600   -23.96300 35.07100  1.000 23.26170 ? 180 TRP B CE2 1 
ATOM   1030 C CE3 . TRP A 1 129 ? 3.62800   -23.38200 35.97500  1.000 24.31077 ? 180 TRP B CE3 1 
ATOM   1031 C CZ2 . TRP A 1 129 ? 5.41000   -25.28800 34.90600  1.000 23.69253 ? 180 TRP B CZ2 1 
ATOM   1032 C CZ3 . TRP A 1 129 ? 3.25900   -24.69100 35.80600  1.000 24.63075 ? 180 TRP B CZ3 1 
ATOM   1033 C CH2 . TRP A 1 129 ? 4.14600   -25.63100 35.27800  1.000 25.04783 ? 180 TRP B CH2 1 
ATOM   1034 N N   . GLY A 1 130 ? 6.33700   -18.84700 34.01100  1.000 20.19460 ? 181 GLY B N   1 
ATOM   1035 C CA  . GLY A 1 130 ? 7.23600   -18.65600 32.92000  1.000 23.66531 ? 181 GLY B CA  1 
ATOM   1036 C C   . GLY A 1 130 ? 8.69500   -18.81300 33.25600  1.000 26.63866 ? 181 GLY B C   1 
ATOM   1037 O O   . GLY A 1 130 ? 9.07700   -18.85100 34.41100  1.000 22.18768 ? 181 GLY B O   1 
ATOM   1038 N N   . VAL A 1 131 ? 9.50700   -18.93600 32.22400  1.000 22.49001 ? 182 VAL B N   1 
ATOM   1039 C CA  . VAL A 1 131 ? 10.93500  -19.02100 32.41200  1.000 21.84444 ? 182 VAL B CA  1 
ATOM   1040 C C   . VAL A 1 131 ? 11.58900  -18.03300 31.43900  1.000 17.84684 ? 182 VAL B C   1 
ATOM   1041 O O   . VAL A 1 131 ? 11.36300  -18.08800 30.25000  1.000 20.74964 ? 182 VAL B O   1 
ATOM   1042 C CB  . VAL A 1 131 ? 11.47500  -20.46200 32.25600  1.000 22.28833 ? 182 VAL B CB  1 
ATOM   1043 C CG1 . VAL A 1 131 ? 12.99200  -20.47500 32.21000  1.000 19.91644 ? 182 VAL B CG1 1 
ATOM   1044 C CG2 . VAL A 1 131 ? 10.93400  -21.37600 33.34100  1.000 19.17979 ? 182 VAL B CG2 1 
ATOM   1045 N N   . HIS A 1 132 ? 12.36000  -17.12100 31.96800  1.000 19.14870 ? 183 HIS B N   1 
ATOM   1046 C CA  . HIS A 1 132 ? 13.02000  -16.10900 31.14700  1.000 20.92071 ? 183 HIS B CA  1 
ATOM   1047 C C   . HIS A 1 132 ? 14.34100  -16.54400 30.53100  1.000 20.43763 ? 183 HIS B C   1 
ATOM   1048 O O   . HIS A 1 132 ? 15.13900  -17.19200 31.17900  1.000 19.73990 ? 183 HIS B O   1 
ATOM   1049 C CB  . HIS A 1 132 ? 13.22400  -14.81800 31.96200  1.000 22.73243 ? 183 HIS B CB  1 
ATOM   1050 C CG  . HIS A 1 132 ? 13.86000  -13.69300 31.21300  1.000 17.27336 ? 183 HIS B CG  1 
ATOM   1051 N ND1 . HIS A 1 132 ? 14.86200  -12.92200 31.75500  1.000 18.97904 ? 183 HIS B ND1 1 
ATOM   1052 C CD2 . HIS A 1 132 ? 13.61900  -13.18800 29.98300  1.000 14.60332 ? 183 HIS B CD2 1 
ATOM   1053 C CE1 . HIS A 1 132 ? 15.21800  -11.99600 30.88600  1.000 18.01066 ? 183 HIS B CE1 1 
ATOM   1054 N NE2 . HIS A 1 132 ? 14.47800  -12.13600 29.80400  1.000 22.19843 ? 183 HIS B NE2 1 
ATOM   1055 N N   . HIS A 1 133 ? 14.53700  -16.17100 29.28800  1.000 13.56104 ? 184 HIS B N   1 
ATOM   1056 C CA  . HIS A 1 133 ? 15.76000  -16.47900 28.58600  1.000 18.71791 ? 184 HIS B CA  1 
ATOM   1057 C C   . HIS A 1 133 ? 16.33300  -15.16200 28.04400  1.000 18.36408 ? 184 HIS B C   1 
ATOM   1058 O O   . HIS A 1 133 ? 15.84800  -14.63100 27.06600  1.000 16.14225 ? 184 HIS B O   1 
ATOM   1059 C CB  . HIS A 1 133 ? 15.51700  -17.47800 27.47300  1.000 14.12528 ? 184 HIS B CB  1 
ATOM   1060 C CG  . HIS A 1 133 ? 14.86000  -18.74400 27.91600  1.000 19.93733 ? 184 HIS B CG  1 
ATOM   1061 N ND1 . HIS A 1 133 ? 15.50200  -19.96000 27.89500  1.000 21.62932 ? 184 HIS B ND1 1 
ATOM   1062 C CD2 . HIS A 1 133 ? 13.61500  -18.98400 28.38600  1.000 19.61783 ? 184 HIS B CD2 1 
ATOM   1063 C CE1 . HIS A 1 133 ? 14.68200  -20.89500 28.33600  1.000 17.00973 ? 184 HIS B CE1 1 
ATOM   1064 N NE2 . HIS A 1 133 ? 13.53100  -20.32800 28.64200  1.000 20.33999 ? 184 HIS B NE2 1 
ATOM   1065 N N   . PRO A 1 134 ? 17.34000  -14.67000 28.77000  1.000 19.16388 ? 185 PRO B N   1 
ATOM   1066 C CA  . PRO A 1 134 ? 17.92900  -13.42600 28.32000  1.000 18.34852 ? 185 PRO B CA  1 
ATOM   1067 C C   . PRO A 1 134 ? 18.67900  -13.57300 26.98300  1.000 15.54938 ? 185 PRO B C   1 
ATOM   1068 O O   . PRO A 1 134 ? 19.08400  -14.65000 26.61600  1.000 17.64417 ? 185 PRO B O   1 
ATOM   1069 C CB  . PRO A 1 134 ? 18.86500  -13.07200 29.46400  1.000 19.57721 ? 185 PRO B CB  1 
ATOM   1070 C CG  . PRO A 1 134 ? 18.38500  -13.83600 30.63700  1.000 19.45538 ? 185 PRO B CG  1 
ATOM   1071 C CD  . PRO A 1 134 ? 17.92200  -15.11400 30.04500  1.000 15.96008 ? 185 PRO B CD  1 
ATOM   1072 N N   . PRO A 1 135 ? 18.82600  -12.46400 26.25600  1.000 20.20974 ? 186 PRO B N   1 
ATOM   1073 C CA  . PRO A 1 135 ? 19.58500  -12.50000 25.00000  1.000 18.16444 ? 186 PRO B CA  1 
ATOM   1074 C C   . PRO A 1 135 ? 21.09500  -12.50200 25.19800  1.000 23.88922 ? 186 PRO B C   1 
ATOM   1075 O O   . PRO A 1 135 ? 21.79400  -12.92600 24.30400  1.000 20.62852 ? 186 PRO B O   1 
ATOM   1076 C CB  . PRO A 1 135 ? 19.20500  -11.18800 24.35800  1.000 16.04991 ? 186 PRO B CB  1 
ATOM   1077 C CG  . PRO A 1 135 ? 18.96100  -10.26800 25.48800  1.000 21.37134 ? 186 PRO B CG  1 
ATOM   1078 C CD  . PRO A 1 135 ? 18.30900  -11.11000 26.53400  1.000 16.95881 ? 186 PRO B CD  1 
ATOM   1079 N N   . THR A 1 136 ? 21.55900  -12.02400 26.34000  1.000 20.13743 ? 187 THR B N   1 
ATOM   1080 C CA  . THR A 1 136 ? 22.97700  -11.89200 26.61900  1.000 20.45932 ? 187 THR B CA  1 
ATOM   1081 C C   . THR A 1 136 ? 23.35200  -12.28000 28.04500  1.000 24.57808 ? 187 THR B C   1 
ATOM   1082 O O   . THR A 1 136 ? 22.53100  -12.18700 28.93300  1.000 20.76899 ? 187 THR B O   1 
ATOM   1083 C CB  . THR A 1 136 ? 23.44000  -10.42200 26.42100  1.000 18.86544 ? 187 THR B CB  1 
ATOM   1084 O OG1 . THR A 1 136 ? 22.85200  -9.58100  27.41400  1.000 20.34111 ? 187 THR B OG1 1 
ATOM   1085 C CG2 . THR A 1 136 ? 23.08100  -9.91900  25.04000  1.000 24.23567 ? 187 THR B CG2 1 
ATOM   1086 N N   . ILE A 1 137 ? 24.59800  -12.69800 28.24900  1.000 25.61338 ? 188 ILE B N   1 
ATOM   1087 C CA  . ILE A 1 137 ? 25.09600  -13.05100 29.58500  1.000 24.82164 ? 188 ILE B CA  1 
ATOM   1088 C C   . ILE A 1 137 ? 25.08900  -11.82900 30.50300  1.000 25.42787 ? 188 ILE B C   1 
ATOM   1089 O O   . ILE A 1 137 ? 24.89100  -11.95100 31.68500  1.000 25.79410 ? 188 ILE B O   1 
ATOM   1090 C CB  . ILE A 1 137 ? 26.49000  -13.70800 29.49900  1.000 23.69042 ? 188 ILE B CB  1 
ATOM   1091 C CG1 . ILE A 1 137 ? 26.85900  -14.34600 30.83500  1.000 26.41824 ? 188 ILE B CG1 1 
ATOM   1092 C CG2 . ILE A 1 137 ? 27.52500  -12.69200 29.05800  1.000 32.04075 ? 188 ILE B CG2 1 
ATOM   1093 C CD1 . ILE A 1 137 ? 25.84500  -15.35000 31.32500  1.000 26.27964 ? 188 ILE B CD1 1 
ATOM   1094 N N   . GLN A 1 138 ? 25.25400  -10.65400 29.92000  1.000 21.99620 ? 189 GLN B N   1 
ATOM   1095 C CA  . GLN A 1 138 ? 25.22200  -9.42400  30.68700  1.000 27.29248 ? 189 GLN B CA  1 
ATOM   1096 C C   . GLN A 1 138 ? 23.86100  -9.18300  31.31500  1.000 26.62225 ? 189 GLN B C   1 
ATOM   1097 O O   . GLN A 1 138 ? 23.77500  -8.75500  32.43500  1.000 23.09075 ? 189 GLN B O   1 
ATOM   1098 C CB  . GLN A 1 138 ? 25.62400  -8.22800  29.80800  1.000 27.53174 ? 189 GLN B CB  1 
ATOM   1099 C CG  . GLN A 1 138 ? 27.05900  -8.22900  29.32600  1.000 41.33697 ? 189 GLN B CG  1 
ATOM   1100 C CD  . GLN A 1 138 ? 27.26300  -8.96200  28.01300  1.000 50.91253 ? 189 GLN B CD  1 
ATOM   1101 O OE1 . GLN A 1 138 ? 26.38500  -9.66000  27.52300  1.000 31.14023 ? 189 GLN B OE1 1 
ATOM   1102 N NE2 . GLN A 1 138 ? 28.44400  -8.80100  27.44200  1.000 64.60206 ? 189 GLN B NE2 1 
ATOM   1103 N N   . GLU A 1 139 ? 22.80300  -9.47200  30.57500  1.000 25.28097 ? 190 GLU B N   1 
ATOM   1104 C CA  . GLU A 1 139 ? 21.46100  -9.32100  31.11300  1.000 22.50526 ? 190 GLU B CA  1 
ATOM   1105 C C   . GLU A 1 139 ? 21.15600  -10.42000 32.13100  1.000 23.10747 ? 190 GLU B C   1 
ATOM   1106 O O   . GLU A 1 139 ? 20.49500  -10.15600 33.10900  1.000 23.47003 ? 190 GLU B O   1 
ATOM   1107 C CB  . GLU A 1 139 ? 20.41200  -9.23100  30.00300  1.000 21.93527 ? 190 GLU B CB  1 
ATOM   1108 C CG  . GLU A 1 139 ? 18.97400  -9.15400  30.46200  1.000 24.49851 ? 190 GLU B CG  1 
ATOM   1109 C CD  . GLU A 1 139 ? 18.02500  -8.94000  29.30200  1.000 33.55059 ? 190 GLU B CD  1 
ATOM   1110 O OE1 . GLU A 1 139 ? 18.44600  -8.33300  28.30000  1.000 31.93584 ? 190 GLU B OE1 1 
ATOM   1111 O OE2 . GLU A 1 139 ? 16.86600  -9.37200  29.39400  1.000 34.08110 ? 190 GLU B OE2 1 
ATOM   1112 N N   . GLN A 1 140 ? 21.66500  -11.62700 31.90400  1.000 18.90547 ? 191 GLN B N   1 
ATOM   1113 C CA  . GLN A 1 140 ? 21.46600  -12.71400 32.85100  1.000 20.75794 ? 191 GLN B CA  1 
ATOM   1114 C C   . GLN A 1 140 ? 22.03200  -12.32700 34.20300  1.000 24.81093 ? 191 GLN B C   1 
ATOM   1115 O O   . GLN A 1 140 ? 21.36500  -12.42800 35.20300  1.000 23.68659 ? 191 GLN B O   1 
ATOM   1116 C CB  . GLN A 1 140 ? 22.12100  -14.00700 32.38700  1.000 19.51541 ? 191 GLN B CB  1 
ATOM   1117 C CG  . GLN A 1 140 ? 22.16500  -15.10600 33.42700  1.000 19.94403 ? 191 GLN B CG  1 
ATOM   1118 C CD  . GLN A 1 140 ? 20.80500  -15.68700 33.72500  1.000 26.63756 ? 191 GLN B CD  1 
ATOM   1119 O OE1 . GLN A 1 140 ? 19.88400  -15.56100 32.93300  1.000 22.65494 ? 191 GLN B OE1 1 
ATOM   1120 N NE2 . GLN A 1 140 ? 20.68100  -16.34200 34.86600  1.000 23.18963 ? 191 GLN B NE2 1 
ATOM   1121 N N   . THR A 1 141 ? 23.24700  -11.84700 34.22200  1.000 27.28047 ? 192 THR B N   1 
ATOM   1122 C CA  . THR A 1 141 ? 23.90500  -11.48200 35.45800  1.000 25.24089 ? 192 THR B CA  1 
ATOM   1123 C C   . THR A 1 141 ? 23.28800  -10.24800 36.07800  1.000 26.92463 ? 192 THR B C   1 
ATOM   1124 O O   . THR A 1 141 ? 23.06600  -10.19400 37.26500  1.000 33.39590 ? 192 THR B O   1 
ATOM   1125 C CB  . THR A 1 141 ? 25.41500  -11.29900 35.20800  1.000 23.35317 ? 192 THR B CB  1 
ATOM   1126 O OG1 . THR A 1 141 ? 25.63000  -10.36700 34.14800  1.000 30.26403 ? 192 THR B OG1 1 
ATOM   1127 C CG2 . THR A 1 141 ? 26.04000  -12.62400 34.83800  1.000 24.55869 ? 192 THR B CG2 1 
ATOM   1128 N N   . SER A 1 142 ? 22.97000  -9.28000  35.25600  1.000 25.40637 ? 193 SER B N   1 
ATOM   1129 C CA  . SER A 1 142 ? 22.35900  -8.05200  35.77000  1.000 30.92572 ? 193 SER B CA  1 
ATOM   1130 C C   . SER A 1 142 ? 21.05600  -8.31800  36.51500  1.000 29.95983 ? 193 SER B C   1 
ATOM   1131 O O   . SER A 1 142 ? 20.74400  -7.64000  37.46000  1.000 30.03760 ? 193 SER B O   1 
ATOM   1132 C CB  . SER A 1 142 ? 22.10000  -7.07100  34.64100  1.000 28.62937 ? 193 SER B CB  1 
ATOM   1133 O OG  . SER A 1 142 ? 21.17600  -6.07600  35.01500  1.000 43.19015 ? 193 SER B OG  1 
ATOM   1134 N N   . LEU A 1 143 ? 20.32000  -9.33200  36.09800  1.000 28.57040 ? 194 LEU B N   1 
ATOM   1135 C CA  . LEU A 1 143 ? 19.05100  -9.60000  36.72600  1.000 27.58890 ? 194 LEU B CA  1 
ATOM   1136 C C   . LEU A 1 143 ? 19.09000  -10.67900 37.76000  1.000 25.76914 ? 194 LEU B C   1 
ATOM   1137 O O   . LEU A 1 143 ? 18.41000  -10.58800 38.75800  1.000 29.45714 ? 194 LEU B O   1 
ATOM   1138 C CB  . LEU A 1 143 ? 18.06600  -10.03900 35.64300  1.000 25.93326 ? 194 LEU B CB  1 
ATOM   1139 C CG  . LEU A 1 143 ? 17.69300  -9.07100  34.52400  1.000 30.51605 ? 194 LEU B CG  1 
ATOM   1140 C CD1 . LEU A 1 143 ? 16.86200  -9.79200  33.47600  1.000 24.62929 ? 194 LEU B CD1 1 
ATOM   1141 C CD2 . LEU A 1 143 ? 16.95100  -7.86800  35.07700  1.000 30.38577 ? 194 LEU B CD2 1 
ATOM   1142 N N   . TYR A 1 144 ? 19.87000  -11.70400 37.51700  1.000 20.31542 ? 195 TYR B N   1 
ATOM   1143 C CA  . TYR A 1 144 ? 19.87000  -12.86200 38.38200  1.000 22.47747 ? 195 TYR B CA  1 
ATOM   1144 C C   . TYR A 1 144 ? 21.21800  -13.17700 39.04100  1.000 23.10615 ? 195 TYR B C   1 
ATOM   1145 O O   . TYR A 1 144 ? 21.32200  -14.14600 39.75300  1.000 25.29311 ? 195 TYR B O   1 
ATOM   1146 C CB  . TYR A 1 144 ? 19.38600  -14.03800 37.54200  1.000 22.32471 ? 195 TYR B CB  1 
ATOM   1147 C CG  . TYR A 1 144 ? 18.16300  -13.73400 36.71800  1.000 25.13219 ? 195 TYR B CG  1 
ATOM   1148 C CD1 . TYR A 1 144 ? 16.96500  -13.38900 37.32200  1.000 24.22830 ? 195 TYR B CD1 1 
ATOM   1149 C CD2 . TYR A 1 144 ? 18.20500  -13.78900 35.33400  1.000 27.90983 ? 195 TYR B CD2 1 
ATOM   1150 C CE1 . TYR A 1 144 ? 15.84700  -13.10500 36.56900  1.000 21.80338 ? 195 TYR B CE1 1 
ATOM   1151 C CE2 . TYR A 1 144 ? 17.09000  -13.51100 34.57600  1.000 16.97775 ? 195 TYR B CE2 1 
ATOM   1152 C CZ  . TYR A 1 144 ? 15.91800  -13.16800 35.19800  1.000 21.58297 ? 195 TYR B CZ  1 
ATOM   1153 O OH  . TYR A 1 144 ? 14.81300  -12.88500 34.44200  1.000 27.17948 ? 195 TYR B OH  1 
ATOM   1154 N N   . VAL A 1 145 ? 22.22500  -12.35700 38.79400  1.000 29.39914 ? 196 VAL B N   1 
ATOM   1155 C CA  . VAL A 1 145 ? 23.58300  -12.55300 39.34600  1.000 33.28163 ? 196 VAL B CA  1 
ATOM   1156 C C   . VAL A 1 145 ? 24.31800  -13.77800 38.78700  1.000 27.44201 ? 196 VAL B C   1 
ATOM   1157 O O   . VAL A 1 145 ? 25.36500  -13.64100 38.21100  1.000 33.67166 ? 196 VAL B O   1 
ATOM   1158 C CB  . VAL A 1 145 ? 23.60300  -12.58000 40.89300  1.000 37.67844 ? 196 VAL B CB  1 
ATOM   1159 C CG1 . VAL A 1 145 ? 25.03600  -12.61600 41.39500  1.000 31.31322 ? 196 VAL B CG1 1 
ATOM   1160 C CG2 . VAL A 1 145 ? 22.87300  -11.37200 41.45500  1.000 30.22148 ? 196 VAL B CG2 1 
ATOM   1161 N N   . LYS A 1 146 ? 23.75400  -14.93700 38.95000  1.000 27.46349 ? 197 LYS B N   1 
ATOM   1162 C CA  . LYS A 1 146 ? 24.33700  -16.14100 38.41700  1.000 32.88226 ? 197 LYS B CA  1 
ATOM   1163 C C   . LYS A 1 146 ? 24.21600  -16.32500 36.92400  1.000 33.83197 ? 197 LYS B C   1 
ATOM   1164 O O   . LYS A 1 146 ? 23.19600  -16.04500 36.34200  1.000 32.80420 ? 197 LYS B O   1 
ATOM   1165 C CB  . LYS A 1 146 ? 23.69600  -17.35100 39.09000  1.000 39.03572 ? 197 LYS B CB  1 
ATOM   1166 C CG  . LYS A 1 146 ? 22.19100  -17.38100 39.13300  1.000 36.32651 ? 197 LYS B CG  1 
ATOM   1167 C CD  . LYS A 1 146 ? 21.75300  -18.46100 40.10000  1.000 47.21223 ? 197 LYS B CD  1 
ATOM   1168 C CE  . LYS A 1 146 ? 21.99700  -18.04400 41.54300  1.000 40.88030 ? 197 LYS B CE  1 
ATOM   1169 N NZ  . LYS A 1 146 ? 21.13300  -16.91600 41.97600  1.000 32.32182 ? 197 LYS B NZ  1 
ATOM   1170 N N   . GLU A 1 147 ? 25.26500  -16.83800 36.32300  1.000 33.57225 ? 198 GLU B N   1 
ATOM   1171 C CA  . GLU A 1 147 ? 25.25300  -17.10000 34.90300  1.000 36.32340 ? 198 GLU B CA  1 
ATOM   1172 C C   . GLU A 1 147 ? 24.48200  -18.36600 34.54400  1.000 31.62237 ? 198 GLU B C   1 
ATOM   1173 O O   . GLU A 1 147 ? 23.85600  -18.42700 33.50900  1.000 26.22981 ? 198 GLU B O   1 
ATOM   1174 C CB  . GLU A 1 147 ? 26.68800  -17.17300 34.41400  1.000 34.71942 ? 198 GLU B CB  1 
ATOM   1175 C CG  . GLU A 1 147 ? 27.54700  -15.99700 34.84300  1.000 41.05869 ? 198 GLU B CG  1 
ATOM   1176 C CD  . GLU A 1 147 ? 28.95800  -16.07500 34.29900  1.000 45.77766 ? 198 GLU B CD  1 
ATOM   1177 O OE1 . GLU A 1 147 ? 29.15400  -16.71300 33.25000  1.000 50.86231 ? 198 GLU B OE1 1 
ATOM   1178 O OE2 . GLU A 1 147 ? 29.86700  -15.49400 34.91500  1.000 45.15892 ? 198 GLU B OE2 1 
ATOM   1179 N N   . ASN A 1 148 ? 24.52700  -19.35800 35.41500  1.000 26.02707 ? 199 ASN B N   1 
ATOM   1180 C CA  . ASN A 1 148 ? 23.84600  -20.60700 35.16200  1.000 28.07468 ? 199 ASN B CA  1 
ATOM   1181 C C   . ASN A 1 148 ? 22.78400  -20.85700 36.19600  1.000 33.91291 ? 199 ASN B C   1 
ATOM   1182 O O   . ASN A 1 148 ? 23.09000  -21.18700 37.32100  1.000 40.04091 ? 199 ASN B O   1 
ATOM   1183 C CB  . ASN A 1 148 ? 24.83500  -21.76100 35.12800  1.000 34.40302 ? 199 ASN B CB  1 
ATOM   1184 C CG  . ASN A 1 148 ? 25.94100  -21.54900 34.12500  1.000 39.85592 ? 199 ASN B CG  1 
ATOM   1185 O OD1 . ASN A 1 148 ? 25.74800  -21.72200 32.92900  1.000 43.12033 ? 199 ASN B OD1 1 
ATOM   1186 N ND2 . ASN A 1 148 ? 27.11000  -21.17400 34.61100  1.000 40.92947 ? 199 ASN B ND2 1 
ATOM   1187 N N   . ALA A 1 149 ? 21.53800  -20.72000 35.81400  1.000 30.90537 ? 200 ALA B N   1 
ATOM   1188 C CA  . ALA A 1 149 ? 20.42200  -20.85700 36.73500  1.000 30.63233 ? 200 ALA B CA  1 
ATOM   1189 C C   . ALA A 1 149 ? 19.55400  -22.04600 36.34200  1.000 27.35042 ? 200 ALA B C   1 
ATOM   1190 O O   . ALA A 1 149 ? 19.74900  -22.67400 35.29800  1.000 28.51077 ? 200 ALA B O   1 
ATOM   1191 C CB  . ALA A 1 149 ? 19.57900  -19.57600 36.77400  1.000 29.53670 ? 200 ALA B CB  1 
ATOM   1192 N N   . TYR A 1 150 ? 18.58400  -22.34700 37.20200  1.000 27.79958 ? 201 TYR B N   1 
ATOM   1193 C CA  . TYR A 1 150 ? 17.63500  -23.42300 36.96600  1.000 31.72542 ? 201 TYR B CA  1 
ATOM   1194 C C   . TYR A 1 150 ? 16.27900  -23.01400 37.52100  1.000 31.44339 ? 201 TYR B C   1 
ATOM   1195 O O   . TYR A 1 150 ? 16.18000  -22.17900 38.42200  1.000 32.85167 ? 201 TYR B O   1 
ATOM   1196 C CB  . TYR A 1 150 ? 18.09200  -24.73900 37.61600  1.000 33.54171 ? 201 TYR B CB  1 
ATOM   1197 C CG  . TYR A 1 150 ? 17.85400  -24.78700 39.11200  1.000 44.15024 ? 201 TYR B CG  1 
ATOM   1198 C CD1 . TYR A 1 150 ? 18.81700  -24.32300 39.99800  1.000 39.99649 ? 201 TYR B CD1 1 
ATOM   1199 C CD2 . TYR A 1 150 ? 16.67400  -25.30300 39.63900  1.000 40.20943 ? 201 TYR B CD2 1 
ATOM   1200 C CE1 . TYR A 1 150 ? 18.60800  -24.36000 41.36400  1.000 42.53750 ? 201 TYR B CE1 1 
ATOM   1201 C CE2 . TYR A 1 150 ? 16.45700  -25.34100 41.00300  1.000 47.54553 ? 201 TYR B CE2 1 
ATOM   1202 C CZ  . TYR A 1 150 ? 17.42900  -24.87000 41.86000  1.000 46.93830 ? 201 TYR B CZ  1 
ATOM   1203 O OH  . TYR A 1 150 ? 17.22100  -24.90900 43.22000  1.000 62.28475 ? 201 TYR B OH  1 
ATOM   1204 N N   . VAL A 1 151 ? 15.23000  -23.62300 36.97300  1.000 29.89355 ? 202 VAL B N   1 
ATOM   1205 C CA  . VAL A 1 151 ? 13.87600  -23.50300 37.49700  1.000 26.53805 ? 202 VAL B CA  1 
ATOM   1206 C C   . VAL A 1 151 ? 13.28800  -24.90400 37.58100  1.000 28.32051 ? 202 VAL B C   1 
ATOM   1207 O O   . VAL A 1 151 ? 13.40000  -25.68500 36.63000  1.000 32.68294 ? 202 VAL B O   1 
ATOM   1208 C CB  . VAL A 1 151 ? 12.99000  -22.59300 36.62300  1.000 26.14611 ? 202 VAL B CB  1 
ATOM   1209 C CG1 . VAL A 1 151 ? 11.55600  -22.59700 37.13500  1.000 24.74292 ? 202 VAL B CG1 1 
ATOM   1210 C CG2 . VAL A 1 151 ? 13.53900  -21.17700 36.59400  1.000 25.06296 ? 202 VAL B CG2 1 
ATOM   1211 N N   . SER A 1 152 ? 12.67400  -25.22500 38.71800  1.000 30.52384 ? 203 SER B N   1 
ATOM   1212 C CA  . SER A 1 152 ? 12.09800  -26.54400 38.94800  1.000 34.46991 ? 203 SER B CA  1 
ATOM   1213 C C   . SER A 1 152 ? 10.65300  -26.39200 39.39600  1.000 26.33243 ? 203 SER B C   1 
ATOM   1214 O O   . SER A 1 152 ? 10.36000  -25.61200 40.30700  1.000 29.80832 ? 203 SER B O   1 
ATOM   1215 C CB  . SER A 1 152 ? 12.90300  -27.32300 39.99400  1.000 33.14126 ? 203 SER B CB  1 
ATOM   1216 O OG  . SER A 1 152 ? 12.24400  -28.52700 40.34900  1.000 37.48980 ? 203 SER B OG  1 
ATOM   1217 N N   . VAL A 1 153 ? 9.75600   -27.13200 38.74800  1.000 27.54394 ? 204 VAL B N   1 
ATOM   1218 C CA  . VAL A 1 153 ? 8.33300   -27.13700 39.07100  1.000 28.87437 ? 204 VAL B CA  1 
ATOM   1219 C C   . VAL A 1 153 ? 7.89000   -28.59000 39.16900  1.000 30.46180 ? 204 VAL B C   1 
ATOM   1220 O O   . VAL A 1 153 ? 7.94100   -29.32400 38.17500  1.000 27.26736 ? 204 VAL B O   1 
ATOM   1221 C CB  . VAL A 1 153 ? 7.49700   -26.38800 38.01900  1.000 30.17314 ? 204 VAL B CB  1 
ATOM   1222 C CG1 . VAL A 1 153 ? 6.02500   -26.40600 38.40100  1.000 28.08505 ? 204 VAL B CG1 1 
ATOM   1223 C CG2 . VAL A 1 153 ? 7.99900   -24.95900 37.85000  1.000 23.65491 ? 204 VAL B CG2 1 
ATOM   1224 N N   . VAL A 1 154 ? 7.45300   -29.00500 40.35700  1.000 34.35510 ? 205 VAL B N   1 
ATOM   1225 C CA  . VAL A 1 154 ? 7.14600   -30.40700 40.61900  1.000 42.34566 ? 205 VAL B CA  1 
ATOM   1226 C C   . VAL A 1 154 ? 5.82200   -30.50900 41.36500  1.000 38.57160 ? 205 VAL B C   1 
ATOM   1227 O O   . VAL A 1 154 ? 5.60700   -29.81100 42.36200  1.000 36.41141 ? 205 VAL B O   1 
ATOM   1228 C CB  . VAL A 1 154 ? 8.26800   -31.09700 41.42200  1.000 42.63331 ? 205 VAL B CB  1 
ATOM   1229 C CG1 . VAL A 1 154 ? 7.75900   -32.38000 42.06700  1.000 37.33891 ? 205 VAL B CG1 1 
ATOM   1230 C CG2 . VAL A 1 154 ? 9.46400   -31.38100 40.52600  1.000 35.43871 ? 205 VAL B CG2 1 
ATOM   1231 N N   . SER A 1 155 ? 4.93600   -31.37700 40.87600  1.000 41.11615 ? 206 SER B N   1 
ATOM   1232 C CA  . SER A 1 155 ? 3.74400   -31.78600 41.61000  1.000 46.40238 ? 206 SER B CA  1 
ATOM   1233 C C   . SER A 1 155 ? 3.67500   -33.30800 41.62400  1.000 46.62622 ? 206 SER B C   1 
ATOM   1234 O O   . SER A 1 155 ? 4.61900   -33.97500 41.19100  1.000 42.34411 ? 206 SER B O   1 
ATOM   1235 C CB  . SER A 1 155 ? 2.48200   -31.18700 40.98600  1.000 36.13483 ? 206 SER B CB  1 
ATOM   1236 O OG  . SER A 1 155 ? 2.05500   -31.94600 39.86700  1.000 39.39620 ? 206 SER B OG  1 
ATOM   1237 N N   . SER A 1 156 ? 2.57000   -33.87300 42.11600  1.000 50.33163 ? 207 SER B N   1 
ATOM   1238 C CA  . SER A 1 156 ? 2.42800   -35.32500 42.09400  1.000 49.16358 ? 207 SER B CA  1 
ATOM   1239 C C   . SER A 1 156 ? 2.20800   -35.86000 40.68600  1.000 44.19298 ? 207 SER B C   1 
ATOM   1240 O O   . SER A 1 156 ? 2.43300   -37.05100 40.44600  1.000 47.95870 ? 207 SER B O   1 
ATOM   1241 C CB  . SER A 1 156 ? 1.28000   -35.76200 43.00400  1.000 50.72967 ? 207 SER B CB  1 
ATOM   1242 O OG  . SER A 1 156 ? 1.55800   -35.45800 44.36000  1.000 54.41977 ? 207 SER B OG  1 
ATOM   1243 N N   . HIS A 1 157 ? 1.77600   -35.01000 39.75100  1.000 52.69616 ? 208 HIS B N   1 
ATOM   1244 C CA  . HIS A 1 157 ? 1.57500   -35.41100 38.36300  1.000 46.44873 ? 208 HIS B CA  1 
ATOM   1245 C C   . HIS A 1 157 ? 2.33600   -34.50600 37.40100  1.000 47.62376 ? 208 HIS B C   1 
ATOM   1246 O O   . HIS A 1 157 ? 2.05700   -34.51400 36.19800  1.000 51.26554 ? 208 HIS B O   1 
ATOM   1247 C CB  . HIS A 1 157 ? 0.08400   -35.42200 38.01600  1.000 51.87447 ? 208 HIS B CB  1 
ATOM   1248 C CG  . HIS A 1 157 ? -0.74300  -36.25200 38.94600  1.000 58.45855 ? 208 HIS B CG  1 
ATOM   1249 N ND1 . HIS A 1 157 ? -0.80900  -37.62700 38.85900  1.000 59.73902 ? 208 HIS B ND1 1 
ATOM   1250 C CD2 . HIS A 1 157 ? -1.53200  -35.90400 39.99000  1.000 58.66856 ? 208 HIS B CD2 1 
ATOM   1251 C CE1 . HIS A 1 157 ? -1.60700  -38.08800 39.80600  1.000 59.55753 ? 208 HIS B CE1 1 
ATOM   1252 N NE2 . HIS A 1 157 ? -2.05800  -37.06300 40.50600  1.000 64.44649 ? 208 HIS B NE2 1 
ATOM   1253 N N   . TYR A 1 158 ? 3.28800   -33.72600 37.90500  1.000 43.60637 ? 209 TYR B N   1 
ATOM   1254 C CA  . TYR A 1 158 ? 4.08000   -32.83600 37.07000  1.000 39.41283 ? 209 TYR B CA  1 
ATOM   1255 C C   . TYR A 1 158 ? 5.46000   -32.68900 37.68800  1.000 36.82764 ? 209 TYR B C   1 
ATOM   1256 O O   . TYR A 1 158 ? 5.59300   -32.58000 38.91000  1.000 39.62571 ? 209 TYR B O   1 
ATOM   1257 C CB  . TYR A 1 158 ? 3.40800   -31.46400 36.91800  1.000 40.21580 ? 209 TYR B CB  1 
ATOM   1258 C CG  . TYR A 1 158 ? 4.07900   -30.53900 35.92100  1.000 35.34717 ? 209 TYR B CG  1 
ATOM   1259 C CD1 . TYR A 1 158 ? 5.18800   -29.78000 36.27800  1.000 38.68183 ? 209 TYR B CD1 1 
ATOM   1260 C CD2 . TYR A 1 158 ? 3.60500   -30.43200 34.62000  1.000 33.26749 ? 209 TYR B CD2 1 
ATOM   1261 C CE1 . TYR A 1 158 ? 5.80100   -28.93800 35.36900  1.000 35.20686 ? 209 TYR B CE1 1 
ATOM   1262 C CE2 . TYR A 1 158 ? 4.21200   -29.59400 33.70500  1.000 33.48151 ? 209 TYR B CE2 1 
ATOM   1263 C CZ  . TYR A 1 158 ? 5.30800   -28.85000 34.08500  1.000 33.28564 ? 209 TYR B CZ  1 
ATOM   1264 O OH  . TYR A 1 158 ? 5.91600   -28.01500 33.17600  1.000 32.10405 ? 209 TYR B OH  1 
ATOM   1265 N N   . SER A 1 159 ? 6.48200   -32.69000 36.83400  1.000 37.52524 ? 210 SER B N   1 
ATOM   1266 C CA  . SER A 1 159 ? 7.86200   -32.52100 37.28600  1.000 39.14831 ? 210 SER B CA  1 
ATOM   1267 C C   . SER A 1 159 ? 8.69200   -32.12700 36.07300  1.000 34.16379 ? 210 SER B C   1 
ATOM   1268 O O   . SER A 1 159 ? 8.82000   -32.91500 35.13100  1.000 39.46240 ? 210 SER B O   1 
ATOM   1269 C CB  . SER A 1 159 ? 8.39400   -33.79800 37.92900  1.000 36.48616 ? 210 SER B CB  1 
ATOM   1270 O OG  . SER A 1 159 ? 9.77800   -33.69100 38.22700  1.000 41.60253 ? 210 SER B OG  1 
ATOM   1271 N N   . ARG A 1 160 ? 9.25400   -30.92100 36.09500  1.000 39.46851 ? 211 ARG B N   1 
ATOM   1272 C CA  . ARG A 1 160 ? 10.05700  -30.45300 34.97700  1.000 32.84437 ? 211 ARG B CA  1 
ATOM   1273 C C   . ARG A 1 160 ? 11.11900  -29.48300 35.47000  1.000 29.48451 ? 211 ARG B C   1 
ATOM   1274 O O   . ARG A 1 160 ? 10.86800  -28.67700 36.37000  1.000 34.05770 ? 211 ARG B O   1 
ATOM   1275 C CB  . ARG A 1 160 ? 9.18800   -29.78300 33.90700  1.000 32.29241 ? 211 ARG B CB  1 
ATOM   1276 C CG  . ARG A 1 160 ? 9.64500   -30.07600 32.48600  1.000 36.71247 ? 211 ARG B CG  1 
ATOM   1277 C CD  . ARG A 1 160 ? 8.81300   -29.32900 31.45600  1.000 44.64935 ? 211 ARG B CD  1 
ATOM   1278 N NE  . ARG A 1 160 ? 9.59700   -28.97100 30.27900  1.000 45.46188 ? 211 ARG B NE  1 
ATOM   1279 C CZ  . ARG A 1 160 ? 9.07900   -28.67800 29.09400  1.000 46.35303 ? 211 ARG B CZ  1 
ATOM   1280 N NH1 . ARG A 1 160 ? 7.77200   -28.69400 28.88900  1.000 37.87596 ? 211 ARG B NH1 1 
ATOM   1281 N NH2 . ARG A 1 160 ? 9.89200   -28.36000 28.09000  1.000 52.34505 ? 211 ARG B NH2 1 
ATOM   1282 N N   . LYS A 1 161 ? 12.30200  -29.57600 34.87300  1.000 26.56579 ? 212 LYS B N   1 
ATOM   1283 C CA  . LYS A 1 161 ? 13.40100  -28.66000 35.13200  1.000 32.69970 ? 212 LYS B CA  1 
ATOM   1284 C C   . LYS A 1 161 ? 13.64100  -27.82200 33.88500  1.000 27.22582 ? 212 LYS B C   1 
ATOM   1285 O O   . LYS A 1 161 ? 13.68600  -28.35700 32.77200  1.000 34.17020 ? 212 LYS B O   1 
ATOM   1286 C CB  . LYS A 1 161 ? 14.67400  -29.41600 35.51800  1.000 31.58970 ? 212 LYS B CB  1 
ATOM   1287 C CG  . LYS A 1 161 ? 15.62500  -28.61300 36.38900  1.000 39.62312 ? 212 LYS B CG  1 
ATOM   1288 C CD  . LYS A 1 161 ? 16.97900  -29.29300 36.51400  1.000 48.01064 ? 212 LYS B CD  1 
ATOM   1289 C CE  . LYS A 1 161 ? 18.11400  -28.29900 36.32000  1.000 44.76574 ? 212 LYS B CE  1 
ATOM   1290 N NZ  . LYS A 1 161 ? 19.35100  -28.72600 37.03200  1.000 68.97971 ? 212 LYS B NZ  1 
ATOM   1291 N N   . PHE A 1 162 ? 13.78900  -26.51400 34.07200  1.000 27.03904 ? 213 PHE B N   1 
ATOM   1292 C CA  . PHE A 1 162 ? 13.97200  -25.57900 32.97200  1.000 28.29219 ? 213 PHE B CA  1 
ATOM   1293 C C   . PHE A 1 162 ? 15.33900  -24.92500 33.09200  1.000 30.80911 ? 213 PHE B C   1 
ATOM   1294 O O   . PHE A 1 162 ? 15.69500  -24.41300 34.15900  1.000 28.02303 ? 213 PHE B O   1 
ATOM   1295 C CB  . PHE A 1 162 ? 12.87200  -24.51300 32.96300  1.000 25.97835 ? 213 PHE B CB  1 
ATOM   1296 C CG  . PHE A 1 162 ? 11.48200  -25.07500 33.05900  1.000 25.72694 ? 213 PHE B CG  1 
ATOM   1297 C CD1 . PHE A 1 162 ? 10.88900  -25.28800 34.29400  1.000 25.66258 ? 213 PHE B CD1 1 
ATOM   1298 C CD2 . PHE A 1 162 ? 10.76900  -25.39300 31.91400  1.000 21.70885 ? 213 PHE B CD2 1 
ATOM   1299 C CE1 . PHE A 1 162 ? 9.61000   -25.80700 34.38600  1.000 26.83291 ? 213 PHE B CE1 1 
ATOM   1300 C CE2 . PHE A 1 162 ? 9.49100   -25.91100 31.99800  1.000 26.83161 ? 213 PHE B CE2 1 
ATOM   1301 C CZ  . PHE A 1 162 ? 8.91000   -26.11900 33.23600  1.000 28.20275 ? 213 PHE B CZ  1 
ATOM   1302 N N   . THR A 1 163 ? 16.10100  -24.94500 32.00000  1.000 28.95055 ? 214 THR B N   1 
ATOM   1303 C CA  . THR A 1 163 ? 17.41600  -24.32500 31.96700  1.000 33.98579 ? 214 THR B CA  1 
ATOM   1304 C C   . THR A 1 163 ? 17.39400  -23.14900 31.00500  1.000 27.27760 ? 214 THR B C   1 
ATOM   1305 O O   . THR A 1 163 ? 17.11800  -23.34200 29.81100  1.000 25.18312 ? 214 THR B O   1 
ATOM   1306 C CB  . THR A 1 163 ? 18.48400  -25.33600 31.55000  1.000 29.80419 ? 214 THR B CB  1 
ATOM   1307 O OG1 . THR A 1 163 ? 18.76700  -26.21000 32.64900  1.000 48.59013 ? 214 THR B OG1 1 
ATOM   1308 C CG2 . THR A 1 163 ? 19.76500  -24.62100 31.14200  1.000 28.86309 ? 214 THR B CG2 1 
ATOM   1309 N N   . PRO A 1 164 ? 17.68200  -21.94000 31.50400  1.000 25.45686 ? 215 PRO B N   1 
ATOM   1310 C CA  . PRO A 1 164 ? 17.76800  -20.80300 30.58400  1.000 26.52107 ? 215 PRO B CA  1 
ATOM   1311 C C   . PRO A 1 164 ? 18.78100  -21.01600 29.47100  1.000 28.27619 ? 215 PRO B C   1 
ATOM   1312 O O   . PRO A 1 164 ? 19.83100  -21.56500 29.70700  1.000 27.20251 ? 215 PRO B O   1 
ATOM   1313 C CB  . PRO A 1 164 ? 18.20700  -19.64100 31.46900  1.000 23.58936 ? 215 PRO B CB  1 
ATOM   1314 C CG  . PRO A 1 164 ? 18.24900  -20.14200 32.86500  1.000 28.78056 ? 215 PRO B CG  1 
ATOM   1315 C CD  . PRO A 1 164 ? 17.66400  -21.51000 32.91100  1.000 30.00714 ? 215 PRO B CD  1 
ATOM   1316 N N   . GLU A 1 165 ? 18.43200  -20.60600 28.27100  1.000 21.51806 ? 216 GLU B N   1 
ATOM   1317 C CA  . GLU A 1 165 ? 19.33700  -20.71800 27.16100  1.000 21.88461 ? 216 GLU B CA  1 
ATOM   1318 C C   . GLU A 1 165 ? 19.57600  -19.31500 26.63300  1.000 25.02568 ? 216 GLU B C   1 
ATOM   1319 O O   . GLU A 1 165 ? 18.70400  -18.72000 26.02500  1.000 22.82382 ? 216 GLU B O   1 
ATOM   1320 C CB  . GLU A 1 165 ? 18.77700  -21.68200 26.13100  1.000 25.83797 ? 216 GLU B CB  1 
ATOM   1321 C CG  . GLU A 1 165 ? 18.72600  -23.10600 26.64800  1.000 34.61501 ? 216 GLU B CG  1 
ATOM   1322 C CD  . GLU A 1 165 ? 18.39100  -24.12000 25.58100  1.000 49.50992 ? 216 GLU B CD  1 
ATOM   1323 O OE1 . GLU A 1 165 ? 17.52900  -23.84500 24.73100  1.000 47.07011 ? 216 GLU B OE1 1 
ATOM   1324 O OE2 . GLU A 1 165 ? 18.99200  -25.20700 25.60600  1.000 57.24989 ? 216 GLU B OE2 1 
ATOM   1325 N N   . ILE A 1 166 ? 20.75300  -18.79300 26.88700  1.000 18.11044 ? 217 ILE B N   1 
ATOM   1326 C CA  . ILE A 1 166 ? 21.04400  -17.42200 26.54300  1.000 19.28875 ? 217 ILE B CA  1 
ATOM   1327 C C   . ILE A 1 166 ? 21.46700  -17.23500 25.11400  1.000 21.93202 ? 217 ILE B C   1 
ATOM   1328 O O   . ILE A 1 166 ? 22.45300  -17.78100 24.68700  1.000 22.43694 ? 217 ILE B O   1 
ATOM   1329 C CB  . ILE A 1 166 ? 22.10300  -16.84900 27.51400  1.000 22.97808 ? 217 ILE B CB  1 
ATOM   1330 C CG1 . ILE A 1 166 ? 21.59000  -16.93500 28.94900  1.000 25.12752 ? 217 ILE B CG1 1 
ATOM   1331 C CG2 . ILE A 1 166 ? 22.47500  -15.42200 27.14300  1.000 22.68170 ? 217 ILE B CG2 1 
ATOM   1332 C CD1 . ILE A 1 166 ? 22.66200  -16.79800 29.99600  1.000 33.42952 ? 217 ILE B CD1 1 
ATOM   1333 N N   . ALA A 1 167 ? 20.69000  -16.44900 24.39400  1.000 21.35870 ? 218 ALA B N   1 
ATOM   1334 C CA  . ALA A 1 167 ? 20.95100  -16.22500 23.00400  1.000 19.07420 ? 218 ALA B CA  1 
ATOM   1335 C C   . ALA A 1 167 ? 20.01700  -15.17900 22.40100  1.000 19.61861 ? 218 ALA B C   1 
ATOM   1336 O O   . ALA A 1 167 ? 18.95000  -14.91800 22.91500  1.000 16.10687 ? 218 ALA B O   1 
ATOM   1337 C CB  . ALA A 1 167 ? 20.82700  -17.52400 22.23300  1.000 14.69272 ? 218 ALA B CB  1 
ATOM   1338 N N   . LYS A 1 168 ? 20.44700  -14.62400 21.29200  1.000 16.74909 ? 219 LYS B N   1 
ATOM   1339 C CA  . LYS A 1 168 ? 19.63600  -13.61300 20.62500  1.000 18.56271 ? 219 LYS B CA  1 
ATOM   1340 C C   . LYS A 1 168 ? 18.68900  -14.31000 19.65800  1.000 20.03285 ? 219 LYS B C   1 
ATOM   1341 O O   . LYS A 1 168 ? 19.12600  -14.90700 18.66900  1.000 20.25094 ? 219 LYS B O   1 
ATOM   1342 C CB  . LYS A 1 168 ? 20.52100  -12.60400 19.90000  1.000 25.61084 ? 219 LYS B CB  1 
ATOM   1343 C CG  . LYS A 1 168 ? 21.45400  -11.83600 20.81900  1.000 28.44233 ? 219 LYS B CG  1 
ATOM   1344 C CD  . LYS A 1 168 ? 21.54800  -10.37400 20.42000  1.000 30.04198 ? 219 LYS B CD  1 
ATOM   1345 C CE  . LYS A 1 168 ? 22.88000  -9.77100  20.83400  1.000 28.08294 ? 219 LYS B CE  1 
ATOM   1346 N NZ  . LYS A 1 168 ? 23.15500  -8.48800  20.12900  1.000 29.56543 ? 219 LYS B NZ  1 
ATOM   1347 N N   . ARG A 1 169 ? 17.41000  -14.18200 19.91700  1.000 21.14209 ? 220 ARG B N   1 
ATOM   1348 C CA  . ARG A 1 169 ? 16.42200  -14.67300 19.00100  1.000 20.05393 ? 220 ARG B CA  1 
ATOM   1349 C C   . ARG A 1 169 ? 16.13600  -13.52200 18.04700  1.000 20.36552 ? 220 ARG B C   1 
ATOM   1350 O O   . ARG A 1 169 ? 16.48000  -12.40100 18.31700  1.000 19.59750 ? 220 ARG B O   1 
ATOM   1351 C CB  . ARG A 1 169 ? 15.13100  -15.05400 19.72100  1.000 13.51613 ? 220 ARG B CB  1 
ATOM   1352 C CG  . ARG A 1 169 ? 15.11900  -16.38600 20.43600  1.000 16.09900 ? 220 ARG B CG  1 
ATOM   1353 C CD  . ARG A 1 169 ? 15.89800  -16.32900 21.72900  1.000 20.53733 ? 220 ARG B CD  1 
ATOM   1354 N NE  . ARG A 1 169 ? 15.63400  -17.48500 22.56600  1.000 21.40194 ? 220 ARG B NE  1 
ATOM   1355 C CZ  . ARG A 1 169 ? 16.30400  -17.77400 23.67100  1.000 17.18179 ? 220 ARG B CZ  1 
ATOM   1356 N NH1 . ARG A 1 169 ? 17.28900  -16.99700 24.06500  1.000 17.74371 ? 220 ARG B NH1 1 
ATOM   1357 N NH2 . ARG A 1 169 ? 15.99600  -18.84800 24.36900  1.000 18.99271 ? 220 ARG B NH2 1 
ATOM   1358 N N   . PRO A 1 170 ? 15.48100  -13.81700 16.92600  1.000 22.56743 ? 221 PRO B N   1 
ATOM   1359 C CA  . PRO A 1 170 ? 15.07200  -12.72400 16.05500  1.000 16.33459 ? 221 PRO B CA  1 
ATOM   1360 C C   . PRO A 1 170 ? 14.19000  -11.76600 16.84100  1.000 19.53958 ? 221 PRO B C   1 
ATOM   1361 O O   . PRO A 1 170 ? 13.45500  -12.20900 17.69600  1.000 18.20733 ? 221 PRO B O   1 
ATOM   1362 C CB  . PRO A 1 170 ? 14.28800  -13.43400 14.95000  1.000 20.47638 ? 221 PRO B CB  1 
ATOM   1363 C CG  . PRO A 1 170 ? 14.83600  -14.81300 14.92300  1.000 19.43703 ? 221 PRO B CG  1 
ATOM   1364 C CD  . PRO A 1 170 ? 15.22100  -15.13500 16.32900  1.000 18.24250 ? 221 PRO B CD  1 
ATOM   1365 N N   . LYS A 1 171 ? 14.29800  -10.47500 16.57600  1.000 18.33924 ? 222 LYS B N   1 
ATOM   1366 C CA  . LYS A 1 171 ? 13.53500  -9.47900  17.31300  1.000 18.44531 ? 222 LYS B CA  1 
ATOM   1367 C C   . LYS A 1 171 ? 12.03100  -9.60800  17.16200  1.000 22.83598 ? 222 LYS B C   1 
ATOM   1368 O O   . LYS A 1 171 ? 11.52500  -9.71600  16.06400  1.000 23.83440 ? 222 LYS B O   1 
ATOM   1369 C CB  . LYS A 1 171 ? 13.94800  -8.06200  16.90800  1.000 25.66227 ? 222 LYS B CB  1 
ATOM   1370 C CG  . LYS A 1 171 ? 14.38700  -7.13000  18.00900  1.000 28.15496 ? 222 LYS B CG  1 
ATOM   1371 C CD  . LYS A 1 171 ? 14.69400  -5.78000  17.38500  1.000 35.26902 ? 222 LYS B CD  1 
ATOM   1372 C CE  . LYS A 1 171 ? 15.21700  -4.76800  18.38400  1.000 43.43195 ? 222 LYS B CE  1 
ATOM   1373 N NZ  . LYS A 1 171 ? 15.36700  -3.43400  17.74500  1.000 41.64675 ? 222 LYS B NZ  1 
ATOM   1374 N N   . VAL A 1 172 ? 11.33900  -9.64900  18.27200  1.000 18.17136 ? 223 VAL B N   1 
ATOM   1375 C CA  . VAL A 1 172 ? 9.90700   -9.67700  18.25200  1.000 19.32350 ? 223 VAL B CA  1 
ATOM   1376 C C   . VAL A 1 172 ? 9.47000   -8.66500  19.29100  1.000 21.75935 ? 223 VAL B C   1 
ATOM   1377 O O   . VAL A 1 172 ? 9.84200   -8.76500  20.44900  1.000 21.58428 ? 223 VAL B O   1 
ATOM   1378 C CB  . VAL A 1 172 ? 9.30900   -11.05200 18.53900  1.000 16.27357 ? 223 VAL B CB  1 
ATOM   1379 C CG1 . VAL A 1 172 ? 7.81600   -10.93900 18.78300  1.000 20.52654 ? 223 VAL B CG1 1 
ATOM   1380 C CG2 . VAL A 1 172 ? 9.60800   -12.02400 17.41500  1.000 20.97335 ? 223 VAL B CG2 1 
ATOM   1381 N N   . ARG A 1 173 ? 8.70100   -7.68500  18.85800  1.000 22.60299 ? 224 ARG B N   1 
ATOM   1382 C CA  . ARG A 1 173 ? 8.26800   -6.62500  19.75300  1.000 22.92817 ? 224 ARG B CA  1 
ATOM   1383 C C   . ARG A 1 173 ? 9.50100   -6.04000  20.45100  1.000 23.27145 ? 224 ARG B C   1 
ATOM   1384 O O   . ARG A 1 173 ? 9.47800   -5.81300  21.63800  1.000 22.65623 ? 224 ARG B O   1 
ATOM   1385 C CB  . ARG A 1 173 ? 7.17500   -7.11500  20.69800  1.000 21.16102 ? 224 ARG B CB  1 
ATOM   1386 C CG  . ARG A 1 173 ? 5.87800   -7.48200  19.99600  1.000 24.96325 ? 224 ARG B CG  1 
ATOM   1387 C CD  . ARG A 1 173 ? 4.80100   -7.98800  20.94300  1.000 22.46888 ? 224 ARG B CD  1 
ATOM   1388 N NE  . ARG A 1 173 ? 4.32200   -6.96800  21.87200  1.000 31.89554 ? 224 ARG B NE  1 
ATOM   1389 C CZ  . ARG A 1 173 ? 3.37200   -6.08000  21.59700  1.000 33.93606 ? 224 ARG B CZ  1 
ATOM   1390 N NH1 . ARG A 1 173 ? 2.79500   -6.06300  20.40600  1.000 27.80907 ? 224 ARG B NH1 1 
ATOM   1391 N NH2 . ARG A 1 173 ? 3.00700   -5.19700  22.51000  1.000 27.21779 ? 224 ARG B NH2 1 
ATOM   1392 N N   . ASP A 1 174 ? 10.56600  -5.83100  19.68600  1.000 20.94503 ? 225 ASP B N   1 
ATOM   1393 C CA  . ASP A 1 174 ? 11.81300  -5.24100  20.18800  1.000 24.74421 ? 225 ASP B CA  1 
ATOM   1394 C C   . ASP A 1 174 ? 12.52200  -6.05100  21.25600  1.000 29.30215 ? 225 ASP B C   1 
ATOM   1395 O O   . ASP A 1 174 ? 13.33900  -5.53300  21.98300  1.000 28.82853 ? 225 ASP B O   1 
ATOM   1396 C CB  . ASP A 1 174 ? 11.57700  -3.81000  20.63900  1.000 35.50059 ? 225 ASP B CB  1 
ATOM   1397 C CG  . ASP A 1 174 ? 11.27100  -2.88800  19.48700  1.000 45.07070 ? 225 ASP B CG  1 
ATOM   1398 O OD1 . ASP A 1 174 ? 11.78800  -3.12500  18.38100  1.000 49.47583 ? 225 ASP B OD1 1 
ATOM   1399 O OD2 . ASP A 1 174 ? 10.51800  -1.92000  19.68800  1.000 57.20569 ? 225 ASP B OD2 1 
ATOM   1400 N N   . GLN A 1 175 ? 12.22000  -7.32700  21.31200  1.000 25.33732 ? 226 GLN B N   1 
ATOM   1401 C CA  . GLN A 1 175 ? 12.80400  -8.18700  22.30500  1.000 21.16681 ? 226 GLN B CA  1 
ATOM   1402 C C   . GLN A 1 175 ? 13.53000  -9.36400  21.64100  1.000 22.81526 ? 226 GLN B C   1 
ATOM   1403 O O   . GLN A 1 175 ? 12.95000  -10.05100 20.81500  1.000 19.14540 ? 226 GLN B O   1 
ATOM   1404 C CB  . GLN A 1 175 ? 11.69200  -8.64900  23.24800  1.000 22.57960 ? 226 GLN B CB  1 
ATOM   1405 C CG  . GLN A 1 175 ? 12.02000  -8.66100  24.71700  1.000 36.46503 ? 226 GLN B CG  1 
ATOM   1406 C CD  . GLN A 1 175 ? 12.27500  -7.28000  25.26400  1.000 26.35551 ? 226 GLN B CD  1 
ATOM   1407 O OE1 . GLN A 1 175 ? 11.52300  -6.34600  25.01300  1.000 38.25685 ? 226 GLN B OE1 1 
ATOM   1408 N NE2 . GLN A 1 175 ? 13.32800  -7.15200  26.02900  1.000 35.40071 ? 226 GLN B NE2 1 
ATOM   1409 N N   . GLU A 1 176 ? 14.79100  -9.56900  21.99300  1.000 18.71932 ? 227 GLU B N   1 
ATOM   1410 C CA  . GLU A 1 176 ? 15.57100  -10.67500 21.45700  1.000 19.66782 ? 227 GLU B CA  1 
ATOM   1411 C C   . GLU A 1 176 ? 15.61000  -11.80800 22.45100  1.000 19.98633 ? 227 GLU B C   1 
ATOM   1412 O O   . GLU A 1 176 ? 16.01400  -12.89200 22.12900  1.000 17.79241 ? 227 GLU B O   1 
ATOM   1413 C CB  . GLU A 1 176 ? 16.95500  -10.18600 21.05700  1.000 22.63214 ? 227 GLU B CB  1 
ATOM   1414 C CG  . GLU A 1 176 ? 16.88100  -9.13700  19.95800  1.000 28.05108 ? 227 GLU B CG  1 
ATOM   1415 C CD  . GLU A 1 176 ? 18.22700  -8.74800  19.38900  1.000 36.15475 ? 227 GLU B CD  1 
ATOM   1416 O OE1 . GLU A 1 176 ? 19.14000  -8.45800  20.16800  1.000 33.48789 ? 227 GLU B OE1 1 
ATOM   1417 O OE2 . GLU A 1 176 ? 18.36200  -8.70900  18.15500  1.000 31.82411 ? 227 GLU B OE2 1 
ATOM   1418 N N   . GLY A 1 177 ? 15.22000  -11.51700 23.66800  1.000 15.73712 ? 228 GLY B N   1 
ATOM   1419 C CA  . GLY A 1 177 ? 15.10900  -12.52600 24.67200  1.000 15.33341 ? 228 GLY B CA  1 
ATOM   1420 C C   . GLY A 1 177 ? 13.71600  -13.09400 24.62100  1.000 20.90347 ? 228 GLY B C   1 
ATOM   1421 O O   . GLY A 1 177 ? 12.91000  -12.67700 23.81100  1.000 17.92928 ? 228 GLY B O   1 
ATOM   1422 N N   . ARG A 1 178 ? 13.43000  -14.04000 25.48600  1.000 18.45778 ? 229 ARG B N   1 
ATOM   1423 C CA  . ARG A 1 178 ? 12.10800  -14.61200 25.53300  1.000 21.19644 ? 229 ARG B CA  1 
ATOM   1424 C C   . ARG A 1 178 ? 11.64100  -15.09700 26.88900  1.000 17.03278 ? 229 ARG B C   1 
ATOM   1425 O O   . ARG A 1 178 ? 12.45300  -15.35700 27.74700  1.000 17.99905 ? 229 ARG B O   1 
ATOM   1426 C CB  . ARG A 1 178 ? 12.02500  -15.80100 24.55700  1.000 17.87271 ? 229 ARG B CB  1 
ATOM   1427 C CG  . ARG A 1 178 ? 12.31500  -15.52700 23.09100  1.000 16.22861 ? 229 ARG B CG  1 
ATOM   1428 C CD  . ARG A 1 178 ? 11.11000  -14.93500 22.39200  1.000 18.95368 ? 229 ARG B CD  1 
ATOM   1429 N NE  . ARG A 1 178 ? 11.26200  -14.91500 20.94800  1.000 17.03782 ? 229 ARG B NE  1 
ATOM   1430 C CZ  . ARG A 1 178 ? 11.76300  -13.89900 20.26000  1.000 21.12803 ? 229 ARG B CZ  1 
ATOM   1431 N NH1 . ARG A 1 178 ? 12.18000  -12.81100 20.88500  1.000 14.26294 ? 229 ARG B NH1 1 
ATOM   1432 N NH2 . ARG A 1 178 ? 11.84800  -13.97500 18.94600  1.000 17.88710 ? 229 ARG B NH2 1 
ATOM   1433 N N   . ILE A 1 179 ? 10.33800  -15.20600 27.06700  1.000 13.71289 ? 230 ILE B N   1 
ATOM   1434 C CA  . ILE A 1 179 ? 9.80600   -15.83000 28.26100  1.000 17.96918 ? 230 ILE B CA  1 
ATOM   1435 C C   . ILE A 1 179 ? 8.94200   -17.00400 27.80100  1.000 20.91283 ? 230 ILE B C   1 
ATOM   1436 O O   . ILE A 1 179 ? 7.92800   -16.80000 27.15200  1.000 19.59203 ? 230 ILE B O   1 
ATOM   1437 C CB  . ILE A 1 179 ? 8.99500   -14.91300 29.18500  1.000 21.34014 ? 230 ILE B CB  1 
ATOM   1438 C CG1 . ILE A 1 179 ? 9.87200   -13.80900 29.76200  1.000 24.46962 ? 230 ILE B CG1 1 
ATOM   1439 C CG2 . ILE A 1 179 ? 8.36200   -15.72000 30.30400  1.000 16.90969 ? 230 ILE B CG2 1 
ATOM   1440 C CD1 . ILE A 1 179 ? 9.09700   -12.80500 30.58200  1.000 21.23155 ? 230 ILE B CD1 1 
ATOM   1441 N N   . ASN A 1 180 ? 9.36900   -18.21300 28.10800  1.000 13.47657 ? 231 ASN B N   1 
ATOM   1442 C CA  . ASN A 1 180 ? 8.58100   -19.38100 27.77200  1.000 18.53847 ? 231 ASN B CA  1 
ATOM   1443 C C   . ASN A 1 180 ? 7.51700   -19.63600 28.83600  1.000 20.17112 ? 231 ASN B C   1 
ATOM   1444 O O   . ASN A 1 180 ? 7.80300   -19.62900 30.00700  1.000 16.88417 ? 231 ASN B O   1 
ATOM   1445 C CB  . ASN A 1 180 ? 9.46700   -20.59200 27.55700  1.000 15.15887 ? 231 ASN B CB  1 
ATOM   1446 C CG  . ASN A 1 180 ? 10.28600  -20.48600 26.29300  1.000 18.56840 ? 231 ASN B CG  1 
ATOM   1447 O OD1 . ASN A 1 180 ? 9.90300   -19.80300 25.35700  1.000 14.42357 ? 231 ASN B OD1 1 
ATOM   1448 N ND2 . ASN A 1 180 ? 11.41600  -21.15700 26.26900  1.000 15.74708 ? 231 ASN B ND2 1 
ATOM   1449 N N   . TYR A 1 181 ? 6.30200   -19.86000 28.39100  1.000 20.90697 ? 232 TYR B N   1 
ATOM   1450 C CA  . TYR A 1 181 ? 5.18700   -20.04400 29.31500  1.000 21.03139 ? 232 TYR B CA  1 
ATOM   1451 C C   . TYR A 1 181 ? 4.72900   -21.50500 29.48700  1.000 20.21686 ? 232 TYR B C   1 
ATOM   1452 O O   . TYR A 1 181 ? 4.60500   -22.24700 28.54000  1.000 18.57990 ? 232 TYR B O   1 
ATOM   1453 C CB  . TYR A 1 181 ? 4.02200   -19.12000 28.93100  1.000 16.19460 ? 232 TYR B CB  1 
ATOM   1454 C CG  . TYR A 1 181 ? 4.41800   -17.70200 28.62800  1.000 16.26372 ? 232 TYR B CG  1 
ATOM   1455 C CD1 . TYR A 1 181 ? 4.59400   -16.78100 29.64100  1.000 17.67015 ? 232 TYR B CD1 1 
ATOM   1456 C CD2 . TYR A 1 181 ? 4.61100   -17.28200 27.32600  1.000 16.31253 ? 232 TYR B CD2 1 
ATOM   1457 C CE1 . TYR A 1 181 ? 4.96200   -15.48300 29.36700  1.000 18.68216 ? 232 TYR B CE1 1 
ATOM   1458 C CE2 . TYR A 1 181 ? 4.97500   -15.98500 27.04200  1.000 19.40791 ? 232 TYR B CE2 1 
ATOM   1459 C CZ  . TYR A 1 181 ? 5.15100   -15.09200 28.06800  1.000 16.86392 ? 232 TYR B CZ  1 
ATOM   1460 O OH  . TYR A 1 181 ? 5.51800   -13.81100 27.79600  1.000 19.33776 ? 232 TYR B OH  1 
ATOM   1461 N N   . TYR A 1 182 ? 4.47600   -21.87200 30.72400  1.000 16.96867 ? 233 TYR B N   1 
ATOM   1462 C CA  . TYR A 1 182 ? 4.06800   -23.21500 31.01800  1.000 24.18988 ? 233 TYR B CA  1 
ATOM   1463 C C   . TYR A 1 182 ? 2.86600   -23.26200 31.97200  1.000 21.98631 ? 233 TYR B C   1 
ATOM   1464 O O   . TYR A 1 182 ? 2.55600   -22.28700 32.62400  1.000 22.13396 ? 233 TYR B O   1 
ATOM   1465 C CB  . TYR A 1 182 ? 5.24300   -23.99600 31.59400  1.000 19.99027 ? 233 TYR B CB  1 
ATOM   1466 C CG  . TYR A 1 182 ? 6.46200   -24.03700 30.72000  1.000 23.75313 ? 233 TYR B CG  1 
ATOM   1467 C CD1 . TYR A 1 182 ? 6.62900   -25.04100 29.78800  1.000 20.31210 ? 233 TYR B CD1 1 
ATOM   1468 C CD2 . TYR A 1 182 ? 7.44600   -23.07200 30.82600  1.000 17.34850 ? 233 TYR B CD2 1 
ATOM   1469 C CE1 . TYR A 1 182 ? 7.74200   -25.08700 28.98800  1.000 17.04482 ? 233 TYR B CE1 1 
ATOM   1470 C CE2 . TYR A 1 182 ? 8.56500   -23.10800 30.02500  1.000 23.32486 ? 233 TYR B CE2 1 
ATOM   1471 C CZ  . TYR A 1 182 ? 8.70500   -24.11900 29.11100  1.000 20.18816 ? 233 TYR B CZ  1 
ATOM   1472 O OH  . TYR A 1 182 ? 9.79900   -24.16500 28.30900  1.000 27.40189 ? 233 TYR B OH  1 
ATOM   1473 N N   . TRP A 1 183 ? 2.20700   -24.40200 32.03400  1.000 25.72439 ? 234 TRP B N   1 
ATOM   1474 C CA  . TRP A 1 183 ? 1.02900   -24.55200 32.86800  1.000 24.99177 ? 234 TRP B CA  1 
ATOM   1475 C C   . TRP A 1 183 ? 0.72200   -25.98500 33.24000  1.000 28.87313 ? 234 TRP B C   1 
ATOM   1476 O O   . TRP A 1 183 ? 1.13400   -26.89700 32.55900  1.000 31.84195 ? 234 TRP B O   1 
ATOM   1477 C CB  . TRP A 1 183 ? -0.20100  -23.97200 32.16900  1.000 22.89773 ? 234 TRP B CB  1 
ATOM   1478 C CG  . TRP A 1 183 ? -0.58300  -24.63600 30.90400  1.000 21.41182 ? 234 TRP B CG  1 
ATOM   1479 C CD1 . TRP A 1 183 ? -0.13100  -24.33900 29.66700  1.000 18.43002 ? 234 TRP B CD1 1 
ATOM   1480 C CD2 . TRP A 1 183 ? -1.51300  -25.70600 30.74700  1.000 25.10801 ? 234 TRP B CD2 1 
ATOM   1481 N NE1 . TRP A 1 183 ? -0.71400  -25.15400 28.74000  1.000 23.95695 ? 234 TRP B NE1 1 
ATOM   1482 C CE2 . TRP A 1 183 ? -1.56900  -26.00800 29.37800  1.000 28.01594 ? 234 TRP B CE2 1 
ATOM   1483 C CE3 . TRP A 1 183 ? -2.30300  -26.44000 31.63100  1.000 28.72141 ? 234 TRP B CE3 1 
ATOM   1484 C CZ2 . TRP A 1 183 ? -2.38200  -27.01200 28.87000  1.000 29.92464 ? 234 TRP B CZ2 1 
ATOM   1485 C CZ3 . TRP A 1 183 ? -3.10600  -27.43500 31.12700  1.000 23.92773 ? 234 TRP B CZ3 1 
ATOM   1486 C CH2 . TRP A 1 183 ? -3.14100  -27.71400 29.76000  1.000 28.11281 ? 234 TRP B CH2 1 
ATOM   1487 N N   . THR A 1 184 ? -0.02700  -26.16400 34.31900  1.000 32.53401 ? 235 THR B N   1 
ATOM   1488 C CA  . THR A 1 184 ? -0.46300  -27.48800 34.73600  1.000 34.57207 ? 235 THR B CA  1 
ATOM   1489 C C   . THR A 1 184 ? -1.72400  -27.33400 35.57200  1.000 34.69521 ? 235 THR B C   1 
ATOM   1490 O O   . THR A 1 184 ? -1.96100  -26.28300 36.17400  1.000 29.84903 ? 235 THR B O   1 
ATOM   1491 C CB  . THR A 1 184 ? 0.62300   -28.22800 35.52900  1.000 33.15638 ? 235 THR B CB  1 
ATOM   1492 O OG1 . THR A 1 184 ? 0.28700   -29.61900 35.62100  1.000 34.77921 ? 235 THR B OG1 1 
ATOM   1493 C CG2 . THR A 1 184 ? 0.76300   -27.65100 36.92700  1.000 25.91411 ? 235 THR B CG2 1 
ATOM   1494 N N   . LEU A 1 185 ? -2.53600  -28.38600 35.59000  1.000 32.33048 ? 236 LEU B N   1 
ATOM   1495 C CA  . LEU A 1 185 ? -3.77600  -28.40600 36.35600  1.000 38.13636 ? 236 LEU B CA  1 
ATOM   1496 C C   . LEU A 1 185 ? -3.52100  -29.15700 37.65700  1.000 40.66438 ? 236 LEU B C   1 
ATOM   1497 O O   . LEU A 1 185 ? -3.23600  -30.35900 37.64400  1.000 37.61767 ? 236 LEU B O   1 
ATOM   1498 C CB  . LEU A 1 185 ? -4.90300  -29.05100 35.55200  1.000 37.24261 ? 236 LEU B CB  1 
ATOM   1499 C CG  . LEU A 1 185 ? -5.60100  -28.12900 34.54900  1.000 35.08687 ? 236 LEU B CG  1 
ATOM   1500 C CD1 . LEU A 1 185 ? -6.23700  -28.93200 33.42500  1.000 39.02051 ? 236 LEU B CD1 1 
ATOM   1501 C CD2 . LEU A 1 185 ? -6.63200  -27.25000 35.24600  1.000 33.21755 ? 236 LEU B CD2 1 
ATOM   1502 N N   . LEU A 1 186 ? -3.62100  -28.44700 38.77800  1.000 36.49361 ? 237 LEU B N   1 
ATOM   1503 C CA  . LEU A 1 186 ? -3.34500  -29.01600 40.09200  1.000 41.70230 ? 237 LEU B CA  1 
ATOM   1504 C C   . LEU A 1 186 ? -4.64100  -29.58200 40.66400  1.000 45.81027 ? 237 LEU B C   1 
ATOM   1505 O O   . LEU A 1 186 ? -5.53700  -28.82600 41.05600  1.000 38.04955 ? 237 LEU B O   1 
ATOM   1506 C CB  . LEU A 1 186 ? -2.74400  -27.95900 41.01500  1.000 33.56747 ? 237 LEU B CB  1 
ATOM   1507 C CG  . LEU A 1 186 ? -2.08700  -28.46000 42.30100  1.000 38.87519 ? 237 LEU B CG  1 
ATOM   1508 C CD1 . LEU A 1 186 ? -0.88200  -29.32900 41.97700  1.000 45.08115 ? 237 LEU B CD1 1 
ATOM   1509 C CD2 . LEU A 1 186 ? -1.68700  -27.29100 43.18700  1.000 48.18660 ? 237 LEU B CD2 1 
ATOM   1510 N N   . GLU A 1 187 ? -4.73900  -30.90900 40.71200  1.000 39.44920 ? 238 GLU B N   1 
ATOM   1511 C CA  . GLU A 1 187 ? -5.93900  -31.55700 41.20900  1.000 51.19701 ? 238 GLU B CA  1 
ATOM   1512 C C   . GLU A 1 187 ? -6.07200  -31.34500 42.71800  1.000 51.40638 ? 238 GLU B C   1 
ATOM   1513 O O   . GLU A 1 187 ? -5.08700  -31.06100 43.40400  1.000 42.31514 ? 238 GLU B O   1 
ATOM   1514 C CB  . GLU A 1 187 ? -5.90900  -33.04800 40.87400  1.000 52.36784 ? 238 GLU B CB  1 
ATOM   1515 C CG  . GLU A 1 187 ? -4.89600  -33.85900 41.66600  1.000 65.44257 ? 238 GLU B CG  1 
ATOM   1516 C CD  . GLU A 1 187 ? -4.61900  -35.21100 41.03600  1.000 75.36331 ? 238 GLU B CD  1 
ATOM   1517 O OE1 . GLU A 1 187 ? -4.94400  -35.38900 39.84200  1.000 72.81162 ? 238 GLU B OE1 1 
ATOM   1518 O OE2 . GLU A 1 187 ? -4.07200  -36.09500 41.73000  1.000 66.98440 ? 238 GLU B OE2 1 
ATOM   1519 N N   . PRO A 1 188 ? -7.28900  -31.46100 43.25600  1.000 51.65153 ? 239 PRO B N   1 
ATOM   1520 C CA  . PRO A 1 188 ? -7.47900  -31.23000 44.69400  1.000 58.20958 ? 239 PRO B CA  1 
ATOM   1521 C C   . PRO A 1 188 ? -6.68900  -32.22500 45.53300  1.000 58.61865 ? 239 PRO B C   1 
ATOM   1522 O O   . PRO A 1 188 ? -6.65700  -33.42400 45.24800  1.000 47.16588 ? 239 PRO B O   1 
ATOM   1523 C CB  . PRO A 1 188 ? -8.99100  -31.40300 44.88700  1.000 53.48108 ? 239 PRO B CB  1 
ATOM   1524 C CG  . PRO A 1 188 ? -9.45600  -32.16100 43.68500  1.000 55.78154 ? 239 PRO B CG  1 
ATOM   1525 C CD  . PRO A 1 188 ? -8.56500  -31.72300 42.57000  1.000 51.64398 ? 239 PRO B CD  1 
ATOM   1526 N N   . GLY A 1 189 ? -6.04900  -31.70800 46.58100  1.000 52.26036 ? 240 GLY B N   1 
ATOM   1527 C CA  . GLY A 1 189 ? -5.20800  -32.50600 47.44300  1.000 53.41024 ? 240 GLY B CA  1 
ATOM   1528 C C   . GLY A 1 189 ? -3.75600  -32.57900 47.02600  1.000 60.38795 ? 240 GLY B C   1 
ATOM   1529 O O   . GLY A 1 189 ? -2.93600  -33.10800 47.78800  1.000 58.21667 ? 240 GLY B O   1 
ATOM   1530 N N   . ASP A 1 190 ? -3.41000  -32.06600 45.85200  1.000 59.06150 ? 241 ASP B N   1 
ATOM   1531 C CA  . ASP A 1 190 ? -2.04100  -32.10600 45.36400  1.000 51.81836 ? 241 ASP B CA  1 
ATOM   1532 C C   . ASP A 1 190 ? -1.29300  -30.83200 45.74700  1.000 47.79549 ? 241 ASP B C   1 
ATOM   1533 O O   . ASP A 1 190 ? -1.88700  -29.80400 46.08000  1.000 43.15620 ? 241 ASP B O   1 
ATOM   1534 C CB  . ASP A 1 190 ? -2.01600  -32.29600 43.84700  1.000 48.45702 ? 241 ASP B CB  1 
ATOM   1535 C CG  . ASP A 1 190 ? -0.71500  -32.89800 43.35800  1.000 46.79881 ? 241 ASP B CG  1 
ATOM   1536 O OD1 . ASP A 1 190 ? 0.23500   -32.99100 44.16400  1.000 52.24108 ? 241 ASP B OD1 1 
ATOM   1537 O OD2 . ASP A 1 190 ? -0.64300  -33.27900 42.17100  1.000 51.29696 ? 241 ASP B OD2 1 
ATOM   1538 N N   . THR A 1 191 ? 0.03400   -30.91800 45.69400  1.000 45.07970 ? 242 THR B N   1 
ATOM   1539 C CA  . THR A 1 191 ? 0.91200   -29.81000 46.04200  1.000 51.25614 ? 242 THR B CA  1 
ATOM   1540 C C   . THR A 1 191 ? 1.88600   -29.57000 44.90000  1.000 47.11254 ? 242 THR B C   1 
ATOM   1541 O O   . THR A 1 191 ? 2.47500   -30.51900 44.37300  1.000 47.26471 ? 242 THR B O   1 
ATOM   1542 C CB  . THR A 1 191 ? 1.67900   -30.09400 47.34000  1.000 52.77811 ? 242 THR B CB  1 
ATOM   1543 O OG1 . THR A 1 191 ? 0.80000   -30.70100 48.29500  1.000 63.84696 ? 242 THR B OG1 1 
ATOM   1544 C CG2 . THR A 1 191 ? 2.24500   -28.80600 47.92300  1.000 51.78864 ? 242 THR B CG2 1 
ATOM   1545 N N   . ILE A 1 192 ? 2.08400   -28.29800 44.59000  1.000 40.68521 ? 243 ILE B N   1 
ATOM   1546 C CA  . ILE A 1 192 ? 3.02800   -27.90900 43.56200  1.000 37.78776 ? 243 ILE B CA  1 
ATOM   1547 C C   . ILE A 1 192 ? 4.18700   -27.21900 44.22400  1.000 35.93554 ? 243 ILE B C   1 
ATOM   1548 O O   . ILE A 1 192 ? 4.00400   -26.47400 45.16700  1.000 35.63768 ? 243 ILE B O   1 
ATOM   1549 C CB  . ILE A 1 192 ? 2.39500   -26.98500 42.50200  1.000 36.69123 ? 243 ILE B CB  1 
ATOM   1550 C CG1 . ILE A 1 192 ? 3.38300   -26.73700 41.36300  1.000 34.75940 ? 243 ILE B CG1 1 
ATOM   1551 C CG2 . ILE A 1 192 ? 1.92800   -25.67900 43.12700  1.000 33.82828 ? 243 ILE B CG2 1 
ATOM   1552 C CD1 . ILE A 1 192 ? 2.73900   -26.65900 40.00100  1.000 34.49828 ? 243 ILE B CD1 1 
ATOM   1553 N N   . ILE A 1 193 ? 5.37800   -27.44500 43.70700  1.000 37.63528 ? 244 ILE B N   1 
ATOM   1554 C CA  . ILE A 1 193 ? 6.59200   -26.91900 44.32300  1.000 42.22865 ? 244 ILE B CA  1 
ATOM   1555 C C   . ILE A 1 193 ? 7.38100   -26.16200 43.26400  1.000 31.83178 ? 244 ILE B C   1 
ATOM   1556 O O   . ILE A 1 193 ? 7.71100   -26.72000 42.21000  1.000 32.94773 ? 244 ILE B O   1 
ATOM   1557 C CB  . ILE A 1 193 ? 7.44400   -28.03400 44.94800  1.000 38.89499 ? 244 ILE B CB  1 
ATOM   1558 C CG1 . ILE A 1 193 ? 6.64200   -28.78500 46.01300  1.000 46.98730 ? 244 ILE B CG1 1 
ATOM   1559 C CG2 . ILE A 1 193 ? 8.71400   -27.45800 45.55500  1.000 38.37473 ? 244 ILE B CG2 1 
ATOM   1560 C CD1 . ILE A 1 193 ? 7.29500   -30.06700 46.48200  1.000 50.31277 ? 244 ILE B CD1 1 
ATOM   1561 N N   . PHE A 1 194 ? 7.68800   -24.89800 43.54800  1.000 28.30578 ? 245 PHE B N   1 
ATOM   1562 C CA  . PHE A 1 194 ? 8.48100   -24.04400 42.67100  1.000 33.48356 ? 245 PHE B CA  1 
ATOM   1563 C C   . PHE A 1 194 ? 9.85400   -23.83900 43.29800  1.000 36.30910 ? 245 PHE B C   1 
ATOM   1564 O O   . PHE A 1 194 ? 9.95600   -23.32100 44.41500  1.000 37.62059 ? 245 PHE B O   1 
ATOM   1565 C CB  . PHE A 1 194 ? 7.79300   -22.69700 42.44600  1.000 30.50867 ? 245 PHE B CB  1 
ATOM   1566 C CG  . PHE A 1 194 ? 6.64000   -22.75600 41.48800  1.000 35.62878 ? 245 PHE B CG  1 
ATOM   1567 C CD1 . PHE A 1 194 ? 5.36600   -23.07000 41.93500  1.000 33.01776 ? 245 PHE B CD1 1 
ATOM   1568 C CD2 . PHE A 1 194 ? 6.82600   -22.48800 40.14100  1.000 30.11942 ? 245 PHE B CD2 1 
ATOM   1569 C CE1 . PHE A 1 194 ? 4.30100   -23.12500 41.05500  1.000 31.30901 ? 245 PHE B CE1 1 
ATOM   1570 C CE2 . PHE A 1 194 ? 5.76500   -22.54100 39.25600  1.000 28.79336 ? 245 PHE B CE2 1 
ATOM   1571 C CZ  . PHE A 1 194 ? 4.50100   -22.86200 39.71300  1.000 32.45303 ? 245 PHE B CZ  1 
ATOM   1572 N N   . GLU A 1 195 ? 10.90200  -24.24100 42.58200  1.000 31.35784 ? 246 GLU B N   1 
ATOM   1573 C CA  . GLU A 1 195 ? 12.27600  -24.08300 43.04100  1.000 40.07463 ? 246 GLU B CA  1 
ATOM   1574 C C   . GLU A 1 195 ? 13.10100  -23.45700 41.92900  1.000 31.52675 ? 246 GLU B C   1 
ATOM   1575 O O   . GLU A 1 195 ? 13.02000  -23.89000 40.77500  1.000 30.58951 ? 246 GLU B O   1 
ATOM   1576 C CB  . GLU A 1 195 ? 12.88100  -25.42900 43.45900  1.000 38.78098 ? 246 GLU B CB  1 
ATOM   1577 C CG  . GLU A 1 195 ? 12.09700  -26.15600 44.53800  1.000 37.62520 ? 246 GLU B CG  1 
ATOM   1578 C CD  . GLU A 1 195 ? 12.99400  -26.84800 45.54400  1.000 48.12236 ? 246 GLU B CD  1 
ATOM   1579 O OE1 . GLU A 1 195 ? 13.84400  -27.66000 45.12400  1.000 59.85996 ? 246 GLU B OE1 1 
ATOM   1580 O OE2 . GLU A 1 195 ? 12.84700  -26.58000 46.75600  1.000 64.41329 ? 246 GLU B OE2 1 
ATOM   1581 N N   . ALA A 1 196 ? 13.89400  -22.44500 42.27500  1.000 27.39044 ? 247 ALA B N   1 
ATOM   1582 C CA  . ALA A 1 196 ? 14.69900  -21.75000 41.28000  1.000 35.67555 ? 247 ALA B CA  1 
ATOM   1583 C C   . ALA A 1 196 ? 15.75700  -20.91400 41.98100  1.000 32.46662 ? 247 ALA B C   1 
ATOM   1584 O O   . ALA A 1 196 ? 15.60000  -20.52200 43.14000  1.000 37.78264 ? 247 ALA B O   1 
ATOM   1585 C CB  . ALA A 1 196 ? 13.83600  -20.86200 40.37600  1.000 26.78938 ? 247 ALA B CB  1 
ATOM   1586 N N   . ASN A 1 197 ? 16.84300  -20.64600 41.25300  1.000 26.55997 ? 248 ASN B N   1 
ATOM   1587 C CA  . ASN A 1 197 ? 17.83900  -19.66100 41.65900  1.000 30.18667 ? 248 ASN B CA  1 
ATOM   1588 C C   . ASN A 1 197 ? 17.95500  -18.53300 40.63900  1.000 34.66518 ? 248 ASN B C   1 
ATOM   1589 O O   . ASN A 1 197 ? 18.92900  -17.77400 40.66300  1.000 23.34532 ? 248 ASN B O   1 
ATOM   1590 C CB  . ASN A 1 197 ? 19.20100  -20.32100 41.89500  1.000 33.58481 ? 248 ASN B CB  1 
ATOM   1591 C CG  . ASN A 1 197 ? 19.68300  -21.12700 40.70400  1.000 34.25169 ? 248 ASN B CG  1 
ATOM   1592 O OD1 . ASN A 1 197 ? 19.08600  -21.09400 39.63000  1.000 35.69244 ? 248 ASN B OD1 1 
ATOM   1593 N ND2 . ASN A 1 197 ? 20.77600  -21.85800 40.89200  1.000 32.59908 ? 248 ASN B ND2 1 
ATOM   1594 N N   . GLY A 1 198 ? 16.98100  -18.41000 39.75200  1.000 28.95034 ? 249 GLY B N   1 
ATOM   1595 C CA  . GLY A 1 198 ? 16.95600  -17.34200 38.77500  1.000 19.42564 ? 249 GLY B CA  1 
ATOM   1596 C C   . GLY A 1 198 ? 15.98100  -17.63900 37.66200  1.000 22.01159 ? 249 GLY B C   1 
ATOM   1597 O O   . GLY A 1 198 ? 15.51900  -18.76600 37.48400  1.000 22.29874 ? 249 GLY B O   1 
ATOM   1598 N N   . ASN A 1 199 ? 15.68400  -16.60400 36.88100  1.000 21.90594 ? 250 ASN B N   1 
ATOM   1599 C CA  . ASN A 1 199 ? 14.86600  -16.75600 35.66500  1.000 22.31264 ? 250 ASN B CA  1 
ATOM   1600 C C   . ASN A 1 199 ? 13.39500  -17.22800 35.77500  1.000 20.77420 ? 250 ASN B C   1 
ATOM   1601 O O   . ASN A 1 199 ? 12.77700  -17.56400 34.78600  1.000 24.01353 ? 250 ASN B O   1 
ATOM   1602 C CB  . ASN A 1 199 ? 15.64600  -17.62800 34.65700  1.000 17.89816 ? 250 ASN B CB  1 
ATOM   1603 C CG  . ASN A 1 199 ? 17.04500  -17.10800 34.40600  1.000 29.47584 ? 250 ASN B CG  1 
ATOM   1604 O OD1 . ASN A 1 199 ? 17.89800  -17.15500 35.28400  1.000 23.39119 ? 250 ASN B OD1 1 
ATOM   1605 N ND2 . ASN A 1 199 ? 17.28300  -16.60500 33.20900  1.000 18.47023 ? 250 ASN B ND2 1 
ATOM   1606 N N   . LEU A 1 200 ? 12.85100  -17.21000 36.96000  1.000 25.21899 ? 251 LEU B N   1 
ATOM   1607 C CA  . LEU A 1 200 ? 11.47600  -17.63600 37.15200  1.000 25.96083 ? 251 LEU B CA  1 
ATOM   1608 C C   . LEU A 1 200 ? 10.47500  -16.51100 37.04400  1.000 26.92263 ? 251 LEU B C   1 
ATOM   1609 O O   . LEU A 1 200 ? 10.60600  -15.50000 37.71100  1.000 21.14790 ? 251 LEU B O   1 
ATOM   1610 C CB  . LEU A 1 200 ? 11.30000  -18.31200 38.50900  1.000 24.28754 ? 251 LEU B CB  1 
ATOM   1611 C CG  . LEU A 1 200 ? 9.86500   -18.48300 38.99300  1.000 31.71813 ? 251 LEU B CG  1 
ATOM   1612 C CD1 . LEU A 1 200 ? 9.09800   -19.41700 38.07300  1.000 27.33343 ? 251 LEU B CD1 1 
ATOM   1613 C CD2 . LEU A 1 200 ? 9.85600   -18.99000 40.42100  1.000 26.83089 ? 251 LEU B CD2 1 
ATOM   1614 N N   . ILE A 1 201 ? 9.49000   -16.69300 36.18900  1.000 19.99919 ? 252 ILE B N   1 
ATOM   1615 C CA  . ILE A 1 201 ? 8.40900   -15.74100 36.10500  1.000 19.14286 ? 252 ILE B CA  1 
ATOM   1616 C C   . ILE A 1 201 ? 7.36600   -16.43000 36.94200  1.000 21.56416 ? 252 ILE B C   1 
ATOM   1617 O O   . ILE A 1 201 ? 6.67400   -17.30900 36.47500  1.000 20.42331 ? 252 ILE B O   1 
ATOM   1618 C CB  . ILE A 1 201 ? 7.95200   -15.44300 34.67200  1.000 25.94073 ? 252 ILE B CB  1 
ATOM   1619 C CG1 . ILE A 1 201 ? 9.16300   -15.09300 33.80700  1.000 26.55444 ? 252 ILE B CG1 1 
ATOM   1620 C CG2 . ILE A 1 201 ? 6.93300   -14.32100 34.65800  1.000 18.52648 ? 252 ILE B CG2 1 
ATOM   1621 C CD1 . ILE A 1 201 ? 9.95100   -13.90700 34.30400  1.000 26.01057 ? 252 ILE B CD1 1 
ATOM   1622 N N   . ALA A 1 202 ? 7.27500   -16.02400 38.18500  1.000 23.30483 ? 253 ALA B N   1 
ATOM   1623 C CA  . ALA A 1 202 ? 6.42500   -16.70200 39.12900  1.000 23.90103 ? 253 ALA B CA  1 
ATOM   1624 C C   . ALA A 1 202 ? 4.95600   -16.49400 38.99900  1.000 22.30416 ? 253 ALA B C   1 
ATOM   1625 O O   . ALA A 1 202 ? 4.50000   -15.46600 38.55700  1.000 26.59259 ? 253 ALA B O   1 
ATOM   1626 C CB  . ALA A 1 202 ? 6.83400   -16.30000 40.52700  1.000 19.27063 ? 253 ALA B CB  1 
ATOM   1627 N N   . PRO A 1 203 ? 4.22200   -17.49600 39.42600  1.000 22.92707 ? 254 PRO B N   1 
ATOM   1628 C CA  . PRO A 1 203 ? 2.78100   -17.31600 39.44700  1.000 26.81972 ? 254 PRO B CA  1 
ATOM   1629 C C   . PRO A 1 203 ? 2.33900   -16.30800 40.49600  1.000 29.39925 ? 254 PRO B C   1 
ATOM   1630 O O   . PRO A 1 203 ? 2.90900   -16.31300 41.56900  1.000 29.63880 ? 254 PRO B O   1 
ATOM   1631 C CB  . PRO A 1 203 ? 2.27200   -18.69900 39.84300  1.000 25.21713 ? 254 PRO B CB  1 
ATOM   1632 C CG  . PRO A 1 203 ? 3.39500   -19.64100 39.60800  1.000 22.24241 ? 254 PRO B CG  1 
ATOM   1633 C CD  . PRO A 1 203 ? 4.62500   -18.84100 39.85700  1.000 21.57103 ? 254 PRO B CD  1 
ATOM   1634 N N   . ARG A 1 204 ? 1.40400   -15.43800 40.17700  1.000 28.88468 ? 255 ARG B N   1 
ATOM   1635 C CA  . ARG A 1 204 ? 0.79700   -14.53600 41.14700  1.000 30.71663 ? 255 ARG B CA  1 
ATOM   1636 C C   . ARG A 1 204 ? -0.68800  -14.80500 41.31700  1.000 37.88174 ? 255 ARG B C   1 
ATOM   1637 O O   . ARG A 1 204 ? -1.18000  -14.86100 42.45000  1.000 38.87730 ? 255 ARG B O   1 
ATOM   1638 C CB  . ARG A 1 204 ? 1.02400   -13.07300 40.73700  1.000 32.51261 ? 255 ARG B CB  1 
ATOM   1639 C CG  . ARG A 1 204 ? 0.56300   -12.07100 41.78200  1.000 35.80080 ? 255 ARG B CG  1 
ATOM   1640 C CD  . ARG A 1 204 ? 0.46300   -10.67100 41.20600  1.000 43.19798 ? 255 ARG B CD  1 
ATOM   1641 N NE  . ARG A 1 204 ? -0.32400  -9.78900  42.06000  1.000 49.36889 ? 255 ARG B NE  1 
ATOM   1642 C CZ  . ARG A 1 204 ? -0.30200  -8.46500  41.99200  1.000 49.71459 ? 255 ARG B CZ  1 
ATOM   1643 N NH1 . ARG A 1 204 ? 0.45900   -7.83000  41.11500  1.000 49.56352 ? 255 ARG B NH1 1 
ATOM   1644 N NH2 . ARG A 1 204 ? -1.06400  -7.76100  42.82200  1.000 56.26490 ? 255 ARG B NH2 1 
ATOM   1645 N N   . TYR A 1 205 ? -1.41500  -14.98100 40.21700  1.000 30.74374 ? 256 TYR B N   1 
ATOM   1646 C CA  . TYR A 1 205 ? -2.82200  -15.34900 40.24300  1.000 30.71345 ? 256 TYR B CA  1 
ATOM   1647 C C   . TYR A 1 205 ? -2.99300  -16.70000 39.56500  1.000 32.84878 ? 256 TYR B C   1 
ATOM   1648 O O   . TYR A 1 205 ? -2.49200  -16.91000 38.45500  1.000 26.39506 ? 256 TYR B O   1 
ATOM   1649 C CB  . TYR A 1 205 ? -3.68600  -14.29500 39.54300  1.000 21.23662 ? 256 TYR B CB  1 
ATOM   1650 C CG  . TYR A 1 205 ? -3.90700  -13.03700 40.35300  1.000 31.98390 ? 256 TYR B CG  1 
ATOM   1651 C CD1 . TYR A 1 205 ? -4.78500  -13.02600 41.43000  1.000 41.74847 ? 256 TYR B CD1 1 
ATOM   1652 C CD2 . TYR A 1 205 ? -3.24300  -11.85900 40.03800  1.000 36.92941 ? 256 TYR B CD2 1 
ATOM   1653 C CE1 . TYR A 1 205 ? -4.99200  -11.87800 42.17100  1.000 40.95188 ? 256 TYR B CE1 1 
ATOM   1654 C CE2 . TYR A 1 205 ? -3.44400  -10.70600 40.77400  1.000 42.04903 ? 256 TYR B CE2 1 
ATOM   1655 C CZ  . TYR A 1 205 ? -4.31900  -10.72200 41.83900  1.000 38.95606 ? 256 TYR B CZ  1 
ATOM   1656 O OH  . TYR A 1 205 ? -4.52200  -9.57600  42.57500  1.000 40.81885 ? 256 TYR B OH  1 
ATOM   1657 N N   . ALA A 1 206 ? -3.68200  -17.61200 40.24000  1.000 29.11783 ? 257 ALA B N   1 
ATOM   1658 C CA  . ALA A 1 206 ? -4.08500  -18.89000 39.67600  1.000 28.72224 ? 257 ALA B CA  1 
ATOM   1659 C C   . ALA A 1 206 ? -5.60200  -18.92900 39.56100  1.000 31.83461 ? 257 ALA B C   1 
ATOM   1660 O O   . ALA A 1 206 ? -6.30700  -18.02200 40.01100  1.000 30.77474 ? 257 ALA B O   1 
ATOM   1661 C CB  . ALA A 1 206 ? -3.57100  -20.05500 40.53000  1.000 27.18592 ? 257 ALA B CB  1 
ATOM   1662 N N   . PHE A 1 207 ? -6.11000  -19.99700 38.95000  1.000 27.58448 ? 258 PHE B N   1 
ATOM   1663 C CA  . PHE A 1 207 ? -7.53200  -20.11000 38.64900  1.000 32.16476 ? 258 PHE B CA  1 
ATOM   1664 C C   . PHE A 1 207 ? -8.04800  -21.46500 39.10200  1.000 35.55341 ? 258 PHE B C   1 
ATOM   1665 O O   . PHE A 1 207 ? -7.63000  -22.50100 38.57400  1.000 35.68697 ? 258 PHE B O   1 
ATOM   1666 C CB  . PHE A 1 207 ? -7.79300  -19.90900 37.15400  1.000 30.12116 ? 258 PHE B CB  1 
ATOM   1667 C CG  . PHE A 1 207 ? -7.20600  -18.64200 36.60200  1.000 30.39114 ? 258 PHE B CG  1 
ATOM   1668 C CD1 . PHE A 1 207 ? -7.91400  -17.45400 36.65800  1.000 25.19392 ? 258 PHE B CD1 1 
ATOM   1669 C CD2 . PHE A 1 207 ? -5.94300  -18.63900 36.03100  1.000 34.50636 ? 258 PHE B CD2 1 
ATOM   1670 C CE1 . PHE A 1 207 ? -7.37800  -16.28500 36.15000  1.000 30.94427 ? 258 PHE B CE1 1 
ATOM   1671 C CE2 . PHE A 1 207 ? -5.40000  -17.47200 35.52200  1.000 32.08780 ? 258 PHE B CE2 1 
ATOM   1672 C CZ  . PHE A 1 207 ? -6.11800  -16.29400 35.58300  1.000 28.87171 ? 258 PHE B CZ  1 
ATOM   1673 N N   . ALA A 1 208 ? -8.95600  -21.45500 40.07500  1.000 39.91123 ? 259 ALA B N   1 
ATOM   1674 C CA  . ALA A 1 208 ? -9.67600  -22.65300 40.48400  1.000 37.18771 ? 259 ALA B CA  1 
ATOM   1675 C C   . ALA A 1 208 ? -10.90600 -22.79700 39.59900  1.000 33.52143 ? 259 ALA B C   1 
ATOM   1676 O O   . ALA A 1 208 ? -11.72000 -21.87100 39.50600  1.000 37.53431 ? 259 ALA B O   1 
ATOM   1677 C CB  . ALA A 1 208 ? -10.07000 -22.57700 41.95700  1.000 41.41284 ? 259 ALA B CB  1 
ATOM   1678 N N   . LEU A 1 209 ? -11.04500 -23.95100 38.95200  1.000 32.59969 ? 260 LEU B N   1 
ATOM   1679 C CA  . LEU A 1 209 ? -12.06600 -24.09900 37.92800  1.000 37.37598 ? 260 LEU B CA  1 
ATOM   1680 C C   . LEU A 1 209 ? -12.58100 -25.52900 37.89200  1.000 44.33299 ? 260 LEU B C   1 
ATOM   1681 O O   . LEU A 1 209 ? -11.93400 -26.46200 38.37500  1.000 37.07359 ? 260 LEU B O   1 
ATOM   1682 C CB  . LEU A 1 209 ? -11.53300 -23.70200 36.54400  1.000 34.26049 ? 260 LEU B CB  1 
ATOM   1683 C CG  . LEU A 1 209 ? -10.62100 -24.70600 35.83000  1.000 28.43873 ? 260 LEU B CG  1 
ATOM   1684 C CD1 . LEU A 1 209 ? -10.56200 -24.40300 34.34300  1.000 35.82096 ? 260 LEU B CD1 1 
ATOM   1685 C CD2 . LEU A 1 209 ? -9.22100  -24.70400 36.42400  1.000 37.53109 ? 260 LEU B CD2 1 
ATOM   1686 N N   . SER A 1 210 ? -13.76800 -25.68200 37.30800  1.000 38.02650 ? 261 SER B N   1 
ATOM   1687 C CA  . SER A 1 210 ? -14.35900 -26.98100 37.00500  1.000 47.28380 ? 261 SER B CA  1 
ATOM   1688 C C   . SER A 1 210 ? -14.57100 -27.04100 35.49900  1.000 38.86802 ? 261 SER B C   1 
ATOM   1689 O O   . SER A 1 210 ? -15.37300 -26.27800 34.95000  1.000 40.36617 ? 261 SER B O   1 
ATOM   1690 C CB  . SER A 1 210 ? -15.67500 -27.18400 37.75600  1.000 43.37060 ? 261 SER B CB  1 
ATOM   1691 O OG  . SER A 1 210 ? -15.53100 -26.90500 39.13800  1.000 53.88962 ? 261 SER B OG  1 
ATOM   1692 N N   . ARG A 1 211 ? -13.84700 -27.93400 34.83100  1.000 42.54245 ? 262 ARG B N   1 
ATOM   1693 C CA  . ARG A 1 211 ? -13.94200 -28.05000 33.38400  1.000 48.89710 ? 262 ARG B CA  1 
ATOM   1694 C C   . ARG A 1 211 ? -15.21100 -28.79200 32.98900  1.000 47.92319 ? 262 ARG B C   1 
ATOM   1695 O O   . ARG A 1 211 ? -15.56800 -29.81000 33.59000  1.000 51.22544 ? 262 ARG B O   1 
ATOM   1696 C CB  . ARG A 1 211 ? -12.71500 -28.76700 32.82200  1.000 52.12291 ? 262 ARG B CB  1 
ATOM   1697 C CG  . ARG A 1 211 ? -11.43500 -27.95100 32.90400  1.000 36.16763 ? 262 ARG B CG  1 
ATOM   1698 C CD  . ARG A 1 211 ? -10.21600 -28.79600 32.57900  1.000 47.56177 ? 262 ARG B CD  1 
ATOM   1699 N NE  . ARG A 1 211 ? -10.04700 -29.89800 33.51900  1.000 49.41786 ? 262 ARG B NE  1 
ATOM   1700 C CZ  . ARG A 1 211 ? -9.66200  -31.12000 33.17800  1.000 58.92209 ? 262 ARG B CZ  1 
ATOM   1701 N NH1 . ARG A 1 211 ? -9.39500  -31.43500 31.92100  1.000 62.08782 ? 262 ARG B NH1 1 
ATOM   1702 N NH2 . ARG A 1 211 ? -9.54200  -32.05000 34.12100  1.000 57.85326 ? 262 ARG B NH2 1 
ATOM   1703 N N   . GLY A 1 212 ? -15.89400 -28.27300 31.97400  1.000 47.83260 ? 263 GLY B N   1 
ATOM   1704 C CA  . GLY A 1 212 ? -17.13400 -28.86400 31.50600  1.000 64.06540 ? 263 GLY B CA  1 
ATOM   1705 C C   . GLY A 1 212 ? -18.31800 -28.54700 32.39700  1.000 62.82598 ? 263 GLY B C   1 
ATOM   1706 O O   . GLY A 1 212 ? -18.15000 -28.12300 33.54100  1.000 62.27657 ? 263 GLY B O   1 
ATOM   1707 N N   . GLN B 2 1   ? 29.404    -10.012   15.426    1     59.31181 ? 1   GLN H N   1 
ATOM   1708 C CA  . GLN B 2 1   ? 29.195    -11.041   16.418    1     48.47105 ? 1   GLN H CA  1 
ATOM   1709 C C   . GLN B 2 1   ? 29.358    -12.471   15.826    1     49.12591 ? 1   GLN H C   1 
ATOM   1710 O O   . GLN B 2 1   ? 30.386    -13.081   16.044    1     53.19147 ? 1   GLN H O   1 
ATOM   1711 C CB  . GLN B 2 1   ? 27.852    -10.814   17.073    1     54.6153  ? 1   GLN H CB  1 
ATOM   1712 C CG  . GLN B 2 1   ? 27.837    -9.704    18.107    1     68.67387 ? 1   GLN H CG  1 
ATOM   1713 C CD  . GLN B 2 1   ? 28.155    -10.199   19.502    1     70.29631 ? 1   GLN H CD  1 
ATOM   1714 O OE1 . GLN B 2 1   ? 28.132    -11.397   19.763    1     62.43763 ? 1   GLN H OE1 1 
ATOM   1715 N NE2 . GLN B 2 1   ? 28.436    -9.271    20.412    1     65.67996 ? 1   GLN H NE2 1 
ATOM   1716 N N   . VAL B 2 2   ? 28.39     -13.001   15.09     1     41.96815 ? 2   VAL H N   1 
ATOM   1717 C CA  . VAL B 2 2   ? 28.574    -14.311   14.476    1     28.17998 ? 2   VAL H CA  1 
ATOM   1718 C C   . VAL B 2 2   ? 28.991    -14.19    13.029    1     23.11152 ? 2   VAL H C   1 
ATOM   1719 O O   . VAL B 2 2   ? 28.467    -13.376   12.302    1     24.93479 ? 2   VAL H O   1 
ATOM   1720 C CB  . VAL B 2 2   ? 27.324    -15.206   14.572    1     27.99746 ? 2   VAL H CB  1 
ATOM   1721 C CG1 . VAL B 2 2   ? 26.219    -14.709   13.658    1     31.94913 ? 2   VAL H CG1 1 
ATOM   1722 C CG2 . VAL B 2 2   ? 27.672    -16.654   14.268    1     20.15576 ? 2   VAL H CG2 1 
ATOM   1723 N N   . GLN B 2 3   ? 29.951    -14.992   12.638    1     18.1153  ? 3   GLN H N   1 
ATOM   1724 C CA  . GLN B 2 3   ? 30.354    -14.997   11.262    1     26.34661 ? 3   GLN H CA  1 
ATOM   1725 C C   . GLN B 2 3   ? 30.326    -16.396   10.688    1     23.94583 ? 3   GLN H C   1 
ATOM   1726 O O   . GLN B 2 3   ? 30.764    -17.333   11.328    1     22.9187  ? 3   GLN H O   1 
ATOM   1727 C CB  . GLN B 2 3   ? 31.742    -14.396   11.088    1     24.49796 ? 3   GLN H CB  1 
ATOM   1728 C CG  . GLN B 2 3   ? 31.887    -12.973   11.582    1     33.18529 ? 3   GLN H CG  1 
ATOM   1729 C CD  . GLN B 2 3   ? 32.869    -12.869   12.728    1     52.79729 ? 3   GLN H CD  1 
ATOM   1730 O OE1 . GLN B 2 3   ? 32.609    -13.345   13.829    1     49.18538 ? 3   GLN H OE1 1 
ATOM   1731 N NE2 . GLN B 2 3   ? 34.012    -12.252   12.468    1     57.54166 ? 3   GLN H NE2 1 
ATOM   1732 N N   . LEU B 2 4   ? 29.798    -16.517   9.489     1     19.76827 ? 4   LEU H N   1 
ATOM   1733 C CA  . LEU B 2 4   ? 29.751    -17.789   8.819     1     19.19408 ? 4   LEU H CA  1 
ATOM   1734 C C   . LEU B 2 4   ? 30.4      -17.684   7.471     1     20.40836 ? 4   LEU H C   1 
ATOM   1735 O O   . LEU B 2 4   ? 30.135    -16.766   6.73      1     23.17494 ? 4   LEU H O   1 
ATOM   1736 C CB  . LEU B 2 4   ? 28.328    -18.271   8.665     1     21.35584 ? 4   LEU H CB  1 
ATOM   1737 C CG  . LEU B 2 4   ? 27.512    -18.64    9.897     1     29.90819 ? 4   LEU H CG  1 
ATOM   1738 C CD1 . LEU B 2 4   ? 26.916    -17.384   10.499    1     33.49154 ? 4   LEU H CD1 1 
ATOM   1739 C CD2 . LEU B 2 4   ? 26.407    -19.59    9.476     1     27.16229 ? 4   LEU H CD2 1 
ATOM   1740 N N   . GLU B 2 5   ? 31.246    -18.637   7.166     1     17.73202 ? 5   GLU H N   1 
ATOM   1741 C CA  . GLU B 2 5   ? 31.938    -18.644   5.901     1     22.92049 ? 5   GLU H CA  1 
ATOM   1742 C C   . GLU B 2 5   ? 31.956    -20.017   5.237     1     17.90063 ? 5   GLU H C   1 
ATOM   1743 O O   . GLU B 2 5   ? 32.454    -20.98    5.785     1     16.48634 ? 5   GLU H O   1 
ATOM   1744 C CB  . GLU B 2 5   ? 33.372    -18.125   6.044     1     26.63633 ? 5   GLU H CB  1 
ATOM   1745 C CG  . GLU B 2 5   ? 34.24     -18.283   4.816     1     31.43089 ? 5   GLU H CG  1 
ATOM   1746 C CD  . GLU B 2 5   ? 35.495    -17.435   4.889     1     50.12203 ? 5   GLU H CD  1 
ATOM   1747 O OE1 . GLU B 2 5   ? 35.419    -16.302   5.399     1     54.0371  ? 5   GLU H OE1 1 
ATOM   1748 O OE2 . GLU B 2 5   ? 36.552    -17.896   4.428     1     53.28265 ? 5   GLU H OE2 1 
ATOM   1749 N N   . GLU B 2 6   ? 31.393    -20.066   4.056     1     20.08239 ? 6   GLU H N   1 
ATOM   1750 C CA  . GLU B 2 6   ? 31.401    -21.299   3.305     1     21.13495 ? 6   GLU H CA  1 
ATOM   1751 C C   . GLU B 2 6   ? 32.755    -21.615   2.693     1     20.09844 ? 6   GLU H C   1 
ATOM   1752 O O   . GLU B 2 6   ? 33.53     -20.722   2.426     1     20.89588 ? 6   GLU H O   1 
ATOM   1753 C CB  . GLU B 2 6   ? 30.317    -21.317   2.216     1     19.3205  ? 6   GLU H CB  1 
ATOM   1754 C CG  . GLU B 2 6   ? 28.892    -21.072   2.676     1     18.07953 ? 6   GLU H CG  1 
ATOM   1755 C CD  . GLU B 2 6   ? 28.534    -19.605   2.691     1     19.44472 ? 6   GLU H CD  1 
ATOM   1756 O OE1 . GLU B 2 6   ? 29.447    -18.774   2.615     1     23.37351 ? 6   GLU H OE1 1 
ATOM   1757 O OE2 . GLU B 2 6   ? 27.343    -19.285   2.785     1     23.3054  ? 6   GLU H OE2 1 
ATOM   1758 N N   . SER B 2 7   ? 33.006    -22.891   2.481     1     21.64179 ? 7   SER H N   1 
ATOM   1759 C CA  . SER B 2 7   ? 34.229    -23.366   1.87      1     19.74142 ? 7   SER H CA  1 
ATOM   1760 C C   . SER B 2 7   ? 34.324    -22.868   0.458     1     26.12952 ? 7   SER H C   1 
ATOM   1761 O O   . SER B 2 7   ? 33.324    -22.5     -0.131    1     24.03619 ? 7   SER H O   1 
ATOM   1762 C CB  . SER B 2 7   ? 34.253    -24.903   1.874     1     24.65844 ? 7   SER H CB  1 
ATOM   1763 O OG  . SER B 2 7   ? 33.057    -25.47    1.419     1     25.60947 ? 7   SER H OG  1 
ATOM   1764 N N   . GLY B 2 8   ? 35.509    -22.9     -0.106    1     23.20285 ? 8   GLY H N   1 
ATOM   1765 C CA  . GLY B 2 8   ? 35.739    -22.373   -1.424    1     19.30008 ? 8   GLY H CA  1 
ATOM   1766 C C   . GLY B 2 8   ? 34.989    -22.886   -2.627    1     31.00133 ? 8   GLY H C   1 
ATOM   1767 O O   . GLY B 2 8   ? 34.627    -24.039   -2.703    1     28.55644 ? 8   GLY H O   1 
ATOM   1768 N N   . PRO B 2 9   ? 34.775    -22       -3.594    1     29.98714 ? 9   PRO H N   1 
ATOM   1769 C CA  . PRO B 2 9   ? 33.993    -22.41    -4.755    1     33.58019 ? 9   PRO H CA  1 
ATOM   1770 C C   . PRO B 2 9   ? 34.761    -23.322   -5.687    1     26.31013 ? 9   PRO H C   1 
ATOM   1771 O O   . PRO B 2 9   ? 35.975    -23.33    -5.684    1     30.64036 ? 9   PRO H O   1 
ATOM   1772 C CB  . PRO B 2 9   ? 33.668    -21.084   -5.44     1     23.96405 ? 9   PRO H CB  1 
ATOM   1773 C CG  . PRO B 2 9   ? 34.748    -20.16    -5.016    1     26.57565 ? 9   PRO H CG  1 
ATOM   1774 C CD  . PRO B 2 9   ? 35.135    -20.576   -3.632    1     28.61761 ? 9   PRO H CD  1 
ATOM   1775 N N   . GLY B 2 10  ? 34.032    -24.085   -6.476    1     32.91632 ? 10  GLY H N   1 
ATOM   1776 C CA  . GLY B 2 10  ? 34.669    -25.009   -7.377    1     28.08911 ? 10  GLY H CA  1 
ATOM   1777 C C   . GLY B 2 10  ? 33.888    -26.099   -8.048    1     29.3804  ? 10  GLY H C   1 
ATOM   1778 O O   . GLY B 2 10  ? 32.671    -26.074   -8.087    1     24.58278 ? 10  GLY H O   1 
ATOM   1779 N N   . LEU B 2 11  ? 34.604    -27.084   -8.543    1     23.16324 ? 11  LEU H N   1 
ATOM   1780 C CA  . LEU B 2 11  ? 33.962    -28.132   -9.296    1     30.16931 ? 11  LEU H CA  1 
ATOM   1781 C C   . LEU B 2 11  ? 33.66     -29.451   -8.612    1     24.81247 ? 11  LEU H C   1 
ATOM   1782 O O   . LEU B 2 11  ? 34.329    -29.826   -7.663    1     26.44101 ? 11  LEU H O   1 
ATOM   1783 C CB  . LEU B 2 11  ? 34.839    -28.432   -10.514   1     30.65759 ? 11  LEU H CB  1 
ATOM   1784 C CG  . LEU B 2 11  ? 35.008    -27.427   -11.64    1     33.6782  ? 11  LEU H CG  1 
ATOM   1785 C CD1 . LEU B 2 11  ? 36.135    -27.901   -12.537   1     33.16439 ? 11  LEU H CD1 1 
ATOM   1786 C CD2 . LEU B 2 11  ? 33.714    -27.29    -12.42    1     26.07059 ? 11  LEU H CD2 1 
ATOM   1787 N N   . VAL B 2 12  ? 32.647    -30.135   -9.093    1     19.73005 ? 12  VAL H N   1 
ATOM   1788 C CA  . VAL B 2 12  ? 32.334    -31.464   -8.631    1     21.85609 ? 12  VAL H CA  1 
ATOM   1789 C C   . VAL B 2 12  ? 31.999    -32.248   -9.906    1     23.60251 ? 12  VAL H C   1 
ATOM   1790 O O   . VAL B 2 12  ? 31.212    -31.787   -10.716   1     21.65646 ? 12  VAL H O   1 
ATOM   1791 C CB  . VAL B 2 12  ? 31.155    -31.525   -7.64     1     20.77542 ? 12  VAL H CB  1 
ATOM   1792 C CG1 . VAL B 2 12  ? 30.998    -32.932   -7.097    1     23.68605 ? 12  VAL H CG1 1 
ATOM   1793 C CG2 . VAL B 2 12  ? 31.335    -30.528   -6.516    1     35.48285 ? 12  VAL H CG2 1 
ATOM   1794 N N   . LYS B 2 13  ? 32.585    -33.42    -10.073   1     22.49739 ? 13  LYS H N   1 
ATOM   1795 C CA  . LYS B 2 13  ? 32.291    -34.239   -11.235   1     24.20966 ? 13  LYS H CA  1 
ATOM   1796 C C   . LYS B 2 13  ? 30.894    -34.848   -11.109   1     22.39418 ? 13  LYS H C   1 
ATOM   1797 O O   . LYS B 2 13  ? 30.441    -35.155   -10.003   1     22.702   ? 13  LYS H O   1 
ATOM   1798 C CB  . LYS B 2 13  ? 33.331    -35.345   -11.394   1     24.2501  ? 13  LYS H CB  1 
ATOM   1799 C CG  . LYS B 2 13  ? 34.769    -34.852   -11.384   1     27.53292 ? 13  LYS H CG  1 
ATOM   1800 C CD  . LYS B 2 13  ? 35.737    -35.979   -11.705   0.662 38.1648  ? 13  LYS H CD  1 
ATOM   1801 C CE  . LYS B 2 13  ? 36.659    -35.603   -12.852   1     40.70767 ? 13  LYS H CE  1 
ATOM   1802 N NZ  . LYS B 2 13  ? 37.54     -34.456   -12.502   1     46.67209 ? 13  LYS H NZ  1 
ATOM   1803 N N   . PRO B 2 14  ? 30.188    -35.02    -12.229   1     24.20381 ? 14  PRO H N   1 
ATOM   1804 C CA  . PRO B 2 14  ? 28.845    -35.608   -12.167   1     20.31399 ? 14  PRO H CA  1 
ATOM   1805 C C   . PRO B 2 14  ? 28.879    -37.005   -11.566   1     24.50418 ? 14  PRO H C   1 
ATOM   1806 O O   . PRO B 2 14  ? 29.845    -37.753   -11.731   1     22.3489  ? 14  PRO H O   1 
ATOM   1807 C CB  . PRO B 2 14  ? 28.396    -35.639   -13.634   1     23.1864  ? 14  PRO H CB  1 
ATOM   1808 C CG  . PRO B 2 14  ? 29.275    -34.655   -14.333   1     31.59384 ? 14  PRO H CG  1 
ATOM   1809 C CD  . PRO B 2 14  ? 30.578    -34.66    -13.602   1     24.64888 ? 14  PRO H CD  1 
ATOM   1810 N N   . SER B 2 15  ? 27.806    -37.338   -10.845   1     22.01293 ? 15  SER H N   1 
ATOM   1811 C CA  . SER B 2 15  ? 27.601    -38.585   -10.112   1     26.76349 ? 15  SER H CA  1 
ATOM   1812 C C   . SER B 2 15  ? 28.485    -38.7     -8.875    1     24.20735 ? 15  SER H C   1 
ATOM   1813 O O   . SER B 2 15  ? 28.374    -39.694   -8.146    1     25.92681 ? 15  SER H O   1 
ATOM   1814 C CB  . SER B 2 15  ? 27.815    -39.829   -10.989   1     30.96269 ? 15  SER H CB  1 
ATOM   1815 O OG  . SER B 2 15  ? 29.196    -40.126   -11.11    1     27.36974 ? 15  SER H OG  1 
ATOM   1816 N N   . GLU B 2 16  ? 29.351    -37.726   -8.607    1     26.1492  ? 16  GLU H N   1 
ATOM   1817 C CA  . GLU B 2 16  ? 30.18     -37.751   -7.413    1     20.59093 ? 16  GLU H CA  1 
ATOM   1818 C C   . GLU B 2 16  ? 29.501    -36.97    -6.289    1     17.60897 ? 16  GLU H C   1 
ATOM   1819 O O   . GLU B 2 16  ? 28.384    -36.468   -6.429    1     20.41069 ? 16  GLU H O   1 
ATOM   1820 C CB  . GLU B 2 16  ? 31.571    -37.199   -7.717    1     23.75164 ? 16  GLU H CB  1 
ATOM   1821 C CG  . GLU B 2 16  ? 32.193    -37.775   -8.976    1     31.83327 ? 16  GLU H CG  1 
ATOM   1822 C CD  . GLU B 2 16  ? 33.663    -38.097   -8.805    1     40.84405 ? 16  GLU H CD  1 
ATOM   1823 O OE1 . GLU B 2 16  ? 34.373    -37.307   -8.148    1     45.80722 ? 16  GLU H OE1 1 
ATOM   1824 O OE2 . GLU B 2 16  ? 34.11     -39.141   -9.328    1     48.93831 ? 16  GLU H OE2 1 
ATOM   1825 N N   . THR B 2 17  ? 30.193    -36.836   -5.186    1     20.82522 ? 17  THR H N   1 
ATOM   1826 C CA  . THR B 2 17  ? 29.619    -36.222   -4.023    1     18.10893 ? 17  THR H CA  1 
ATOM   1827 C C   . THR B 2 17  ? 30.154    -34.841   -3.735    1     21.97304 ? 17  THR H C   1 
ATOM   1828 O O   . THR B 2 17  ? 31.351    -34.628   -3.678    1     20.08437 ? 17  THR H O   1 
ATOM   1829 C CB  . THR B 2 17  ? 29.853    -37.125   -2.785    1     18.64889 ? 17  THR H CB  1 
ATOM   1830 O OG1 . THR B 2 17  ? 29.371    -38.445   -3.039    1     22.85958 ? 17  THR H OG1 1 
ATOM   1831 C CG2 . THR B 2 17  ? 29.153    -36.545   -1.569    1     20.44135 ? 17  THR H CG2 1 
ATOM   1832 N N   . LEU B 2 18  ? 29.246    -33.903   -3.59     1     19.59718 ? 18  LEU H N   1 
ATOM   1833 C CA  . LEU B 2 18  ? 29.629    -32.555   -3.226    1     17.08919 ? 18  LEU H CA  1 
ATOM   1834 C C   . LEU B 2 18  ? 29.874    -32.445   -1.738    1     20.70677 ? 18  LEU H C   1 
ATOM   1835 O O   . LEU B 2 18  ? 29.083    -32.935   -0.962    1     18.94545 ? 18  LEU H O   1 
ATOM   1836 C CB  . LEU B 2 18  ? 28.538    -31.598   -3.623    1     15.79507 ? 18  LEU H CB  1 
ATOM   1837 C CG  . LEU B 2 18  ? 28.538    -30.21    -2.986    1     24.86235 ? 18  LEU H CG  1 
ATOM   1838 C CD1 . LEU B 2 18  ? 29.804    -29.453   -3.348    1     28.79116 ? 18  LEU H CD1 1 
ATOM   1839 C CD2 . LEU B 2 18  ? 27.306    -29.436   -3.408    1     17.92572 ? 18  LEU H CD2 1 
ATOM   1840 N N   . SER B 2 19  ? 30.985    -31.837   -1.357    1     21.97659 ? 19  SER H N   1 
ATOM   1841 C CA  . SER B 2 19  ? 31.28     -31.603   0.061     1     19.95078 ? 19  SER H CA  1 
ATOM   1842 C C   . SER B 2 19  ? 31.54     -30.121   0.33      1     20.29617 ? 19  SER H C   1 
ATOM   1843 O O   . SER B 2 19  ? 32.39     -29.519   -0.285    1     25.71779 ? 19  SER H O   1 
ATOM   1844 C CB  . SER B 2 19  ? 32.427    -32.47    0.61      1     20.97979 ? 19  SER H CB  1 
ATOM   1845 O OG  . SER B 2 19  ? 32.591    -32.312   1.999     1     27.2877  ? 19  SER H OG  1 
ATOM   1846 N N   . LEU B 2 20  ? 30.779    -29.55    1.232     1     22.21759 ? 20  LEU H N   1 
ATOM   1847 C CA  . LEU B 2 20  ? 30.965    -28.164   1.619     1     19.41335 ? 20  LEU H CA  1 
ATOM   1848 C C   . LEU B 2 20  ? 31.069    -28.043   3.126     1     22.24648 ? 20  LEU H C   1 
ATOM   1849 O O   . LEU B 2 20  ? 30.475    -28.817   3.842     1     19.76647 ? 20  LEU H O   1 
ATOM   1850 C CB  . LEU B 2 20  ? 29.859    -27.258   1.088     1     15.28891 ? 20  LEU H CB  1 
ATOM   1851 C CG  . LEU B 2 20  ? 29.757    -27.033   -0.416    1     20.19385 ? 20  LEU H CG  1 
ATOM   1852 C CD1 . LEU B 2 20  ? 28.526    -26.202   -0.717    1     19.94098 ? 20  LEU H CD1 1 
ATOM   1853 C CD2 . LEU B 2 20  ? 31.006    -26.355   -0.95     1     17.56503 ? 20  LEU H CD2 1 
ATOM   1854 N N   . THR B 2 21  ? 31.861    -27.097   3.581     1     16.4059  ? 21  THR H N   1 
ATOM   1855 C CA  . THR B 2 21  ? 31.986    -26.832   4.994     1     16.58023 ? 21  THR H CA  1 
ATOM   1856 C C   . THR B 2 21  ? 31.713    -25.366   5.313     1     17.02078 ? 21  THR H C   1 
ATOM   1857 O O   . THR B 2 21  ? 32.001    -24.5     4.507     1     22.18677 ? 21  THR H O   1 
ATOM   1858 C CB  . THR B 2 21  ? 33.369    -27.279   5.536     1     17.46482 ? 21  THR H CB  1 
ATOM   1859 O OG1 . THR B 2 21  ? 33.485    -28.698   5.428     1     28.00841 ? 21  THR H OG1 1 
ATOM   1860 C CG2 . THR B 2 21  ? 33.544    -26.87    6.979     1     22.2065  ? 21  THR H CG2 1 
ATOM   1861 N N   . CYS B 2 22  ? 31.109    -25.106   6.452     1     17.56889 ? 22  CYS H N   1 
ATOM   1862 C CA  . CYS B 2 22  ? 30.862    -23.762   6.907     1     16.51613 ? 22  CYS H CA  1 
ATOM   1863 C C   . CYS B 2 22  ? 31.636    -23.503   8.189     1     17.34327 ? 22  CYS H C   1 
ATOM   1864 O O   . CYS B 2 22  ? 31.464    -24.2     9.152     1     17.59944 ? 22  CYS H O   1 
ATOM   1865 C CB  . CYS B 2 22  ? 29.378    -23.497   7.139     1     17.30558 ? 22  CYS H CB  1 
ATOM   1866 S SG  . CYS B 2 22  ? 28.903    -21.806   7.577     1     21.98674 ? 22  CYS H SG  1 
ATOM   1867 N N   . SER B 2 23  ? 32.478    -22.488   8.162     1     18.17038 ? 23  SER H N   1 
ATOM   1868 C CA  . SER B 2 23  ? 33.267    -22.133   9.323     1     20.2008  ? 23  SER H CA  1 
ATOM   1869 C C   . SER B 2 23  ? 32.511    -21.129   10.151    1     19.40963 ? 23  SER H C   1 
ATOM   1870 O O   . SER B 2 23  ? 32.059    -20.118   9.651     1     23.43726 ? 23  SER H O   1 
ATOM   1871 C CB  . SER B 2 23  ? 34.642    -21.614   8.948     1     21.6669  ? 23  SER H CB  1 
ATOM   1872 O OG  . SER B 2 23  ? 35.446    -22.616   8.37      1     33.40346 ? 23  SER H OG  1 
ATOM   1873 N N   . VAL B 2 24  ? 32.342    -21.449   11.407    1     16.50687 ? 24  VAL H N   1 
ATOM   1874 C CA  . VAL B 2 24  ? 31.581    -20.606   12.288    1     18.87224 ? 24  VAL H CA  1 
ATOM   1875 C C   . VAL B 2 24  ? 32.426    -19.914   13.359    1     24.86722 ? 24  VAL H C   1 
ATOM   1876 O O   . VAL B 2 24  ? 33.227    -20.548   14.012    1     21.10376 ? 24  VAL H O   1 
ATOM   1877 C CB  . VAL B 2 24  ? 30.473    -21.429   12.979    1     21.50477 ? 24  VAL H CB  1 
ATOM   1878 C CG1 . VAL B 2 24  ? 29.716    -20.591   13.998    1     21.18781 ? 24  VAL H CG1 1 
ATOM   1879 C CG2 . VAL B 2 24  ? 29.54     -22.069   11.966    1     19.10636 ? 24  VAL H CG2 1 
ATOM   1880 N N   . SER B 2 25  ? 32.232    -18.625   13.518    1     16.08051 ? 25  SER H N   1 
ATOM   1881 C CA  . SER B 2 25  ? 32.941    -17.874   14.527    1     21.04837 ? 25  SER H CA  1 
ATOM   1882 C C   . SER B 2 25  ? 31.99     -17.036   15.395    1     17.2832  ? 25  SER H C   1 
ATOM   1883 O O   . SER B 2 25  ? 31.062    -16.448   14.898    1     21.07046 ? 25  SER H O   1 
ATOM   1884 C CB  . SER B 2 25  ? 34.016    -16.996   13.869    1     20.90496 ? 25  SER H CB  1 
ATOM   1885 O OG  . SER B 2 25  ? 34.856    -17.723   13.002    1     30.53589 ? 25  SER H OG  1 
ATOM   1886 N N   . GLY B 2 26  ? 32.23     -17.004   16.687    1     16.90667 ? 26  GLY H N   1 
ATOM   1887 C CA  . GLY B 2 26  ? 31.414    -16.211   17.598    1     19.55695 ? 26  GLY H CA  1 
ATOM   1888 C C   . GLY B 2 26  ? 30.544    -16.983   18.557    1     25.06108 ? 26  GLY H C   1 
ATOM   1889 O O   . GLY B 2 26  ? 30.263    -16.493   19.631    1     24.29684 ? 26  GLY H O   1 
ATOM   1890 N N   . VAL B 2 27  ? 30.14     -18.181   18.17     1     21.02226 ? 27  VAL H N   1 
ATOM   1891 C CA  . VAL B 2 27  ? 29.324    -19.031   18.993    1     21.97218 ? 27  VAL H CA  1 
ATOM   1892 C C   . VAL B 2 27  ? 29.767    -20.484   18.794    1     21.11197 ? 27  VAL H C   1 
ATOM   1893 O O   . VAL B 2 27  ? 30.464    -20.797   17.866    1     20.73062 ? 27  VAL H O   1 
ATOM   1894 C CB  . VAL B 2 27  ? 27.81     -18.871   18.683    1     22.74844 ? 27  VAL H CB  1 
ATOM   1895 C CG1 . VAL B 2 27  ? 27.35     -17.444   18.915    1     19.70737 ? 27  VAL H CG1 1 
ATOM   1896 C CG2 . VAL B 2 27  ? 27.483    -19.358   17.285    1     16.24738 ? 27  VAL H CG2 1 
ATOM   1897 N N   . SER B 2 28  ? 29.375    -21.353   19.706    1     23.84826 ? 28  SER H N   1 
ATOM   1898 C CA  . SER B 2 28  ? 29.694    -22.766   19.566    1     21.26815 ? 28  SER H CA  1 
ATOM   1899 C C   . SER B 2 28  ? 28.64     -23.483   18.781    1     20.84073 ? 28  SER H C   1 
ATOM   1900 O O   . SER B 2 28  ? 27.475    -23.265   18.979    1     21.0217  ? 28  SER H O   1 
ATOM   1901 C CB  . SER B 2 28  ? 29.855    -23.499   20.911    1     19.23255 ? 28  SER H CB  1 
ATOM   1902 O OG  . SER B 2 28  ? 29.915    -24.895   20.756    1     22.4681  ? 28  SER H OG  1 
ATOM   1903 N N   . VAL B 2 29  ? 29.075    -24.386   17.942    1     18.86001 ? 29  VAL H N   1 
ATOM   1904 C CA  . VAL B 2 29  ? 28.164    -25.198   17.175    1     18.69423 ? 29  VAL H CA  1 
ATOM   1905 C C   . VAL B 2 29  ? 27.546    -26.306   18.04     1     22.85657 ? 29  VAL H C   1 
ATOM   1906 O O   . VAL B 2 29  ? 26.659    -26.989   17.598    1     21.74111 ? 29  VAL H O   1 
ATOM   1907 C CB  . VAL B 2 29  ? 28.905    -25.794   15.975    1     21.42775 ? 29  VAL H CB  1 
ATOM   1908 C CG1 . VAL B 2 29  ? 29.375    -24.704   15.027    1     17.93146 ? 29  VAL H CG1 1 
ATOM   1909 C CG2 . VAL B 2 29  ? 30.065    -26.653   16.442    1     22.4718  ? 29  VAL H CG2 1 
ATOM   1910 N N   . THR B 2 30  ? 28.024    -26.463   19.266    1     22.29187 ? 30  THR H N   1 
ATOM   1911 C CA  . THR B 2 30  ? 27.474    -27.45    20.193    1     20.17163 ? 30  THR H CA  1 
ATOM   1912 C C   . THR B 2 30  ? 26.269    -26.891   20.934    1     24.73197 ? 30  THR H C   1 
ATOM   1913 O O   . THR B 2 30  ? 25.564    -27.62    21.594    1     23.94867 ? 30  THR H O   1 
ATOM   1914 C CB  . THR B 2 30  ? 28.525    -27.928   21.232    1     22.91666 ? 30  THR H CB  1 
ATOM   1915 O OG1 . THR B 2 30  ? 28.816    -26.875   22.154    1     25.51208 ? 30  THR H OG1 1 
ATOM   1916 C CG2 . THR B 2 30  ? 29.798    -28.364   20.545    1     20.76175 ? 30  THR H CG2 1 
ATOM   1917 N N   . SER B 2 31  ? 26.04     -25.591   20.808    1     21.10481 ? 31  SER H N   1 
ATOM   1918 C CA  . SER B 2 31  ? 24.945    -24.949   21.516    1     25.93169 ? 31  SER H CA  1 
ATOM   1919 C C   . SER B 2 31  ? 23.597    -25.527   21.209    1     26.52505 ? 31  SER H C   1 
ATOM   1920 O O   . SER B 2 31  ? 23.275    -25.762   20.071    1     32.62357 ? 31  SER H O   1 
ATOM   1921 C CB  . SER B 2 31  ? 24.933    -23.444   21.268    1     32.82101 ? 31  SER H CB  1 
ATOM   1922 O OG  . SER B 2 31  ? 25.734    -22.768   22.215    1     35.61272 ? 31  SER H OG  1 
ATOM   1923 N N   . ASP B 2 32  ? 22.821    -25.767   22.237    1     22.18553 ? 32  ASP H N   1 
ATOM   1924 C CA  A ASP B 2 32  ? 21.511    -26.373   22.053    0.495 28.74008 ? 32  ASP H CA  1 
ATOM   1925 C CA  B ASP B 2 32  ? 21.505    -26.372   22.056    0.505 28.75184 ? 32  ASP H CA  1 
ATOM   1926 C C   . ASP B 2 32  ? 20.399    -25.516   21.38     1     25.07941 ? 32  ASP H C   1 
ATOM   1927 O O   . ASP B 2 32  ? 19.426    -25.978   20.703    1     28.41977 ? 32  ASP H O   1 
ATOM   1928 C CB  A ASP B 2 32  ? 21.005    -26.84    23.422    0.495 34.15096 ? 32  ASP H CB  1 
ATOM   1929 C CB  B ASP B 2 32  ? 20.949    -26.827   23.416    0.505 34.15245 ? 32  ASP H CB  1 
ATOM   1930 C CG  A ASP B 2 32  ? 19.882    -27.846   23.322    0.495 38.36064 ? 32  ASP H CG  1 
ATOM   1931 C CG  B ASP B 2 32  ? 22.016    -27.379   24.344    0.505 37.91314 ? 32  ASP H CG  1 
ATOM   1932 O OD1 A ASP B 2 32  ? 19.741    -28.493   22.266    0.495 39.60124 ? 32  ASP H OD1 1 
ATOM   1933 O OD1 B ASP B 2 32  ? 23.134    -27.686   23.884    0.505 37.97471 ? 32  ASP H OD1 1 
ATOM   1934 O OD2 A ASP B 2 32  ? 19.145    -28.002   24.315    0.495 40.99386 ? 32  ASP H OD2 1 
ATOM   1935 O OD2 B ASP B 2 32  ? 21.727    -27.508   25.55     0.505 36.47188 ? 32  ASP H OD2 1 
ATOM   1936 N N   . ILE B 2 33  ? 20.544    -24.211   21.467    1     23.37856 ? 33  ILE H N   1 
ATOM   1937 C CA  . ILE B 2 33  ? 19.526    -23.287   20.964    1     25.17189 ? 33  ILE H CA  1 
ATOM   1938 C C   . ILE B 2 33  ? 19.685    -22.992   19.472    1     17.28418 ? 33  ILE H C   1 
ATOM   1939 O O   . ILE B 2 33  ? 18.74     -22.69    18.804    1     25.21884 ? 33  ILE H O   1 
ATOM   1940 C CB  . ILE B 2 33  ? 19.519    -21.957   21.784    1     22.45579 ? 33  ILE H CB  1 
ATOM   1941 C CG1 . ILE B 2 33  ? 18.315    -21.096   21.421    1     28.97569 ? 33  ILE H CG1 1 
ATOM   1942 C CG2 . ILE B 2 33  ? 20.814    -21.187   21.59     1     15.70174 ? 33  ILE H CG2 1 
ATOM   1943 C CD1 . ILE B 2 33  ? 17.006    -21.664   21.896    1     37.51357 ? 33  ILE H CD1 1 
ATOM   1944 N N   . TYR B 2 34  ? 20.886    -23.111   18.972    1     16.8851  ? 34  TYR H N   1 
ATOM   1945 C CA  . TYR B 2 34  ? 21.139    -22.793   17.597    1     21.62512 ? 34  TYR H CA  1 
ATOM   1946 C C   . TYR B 2 34  ? 21.034    -23.963   16.63     1     19.70294 ? 34  TYR H C   1 
ATOM   1947 O O   . TYR B 2 34  ? 21.471    -25.051   16.94     1     22.82882 ? 34  TYR H O   1 
ATOM   1948 C CB  . TYR B 2 34  ? 22.529    -22.158   17.438    1     16.77971 ? 34  TYR H CB  1 
ATOM   1949 C CG  . TYR B 2 34  ? 22.793    -20.905   18.215    1     16.49986 ? 34  TYR H CG  1 
ATOM   1950 C CD1 . TYR B 2 34  ? 21.996    -19.787   18.064    1     16.12167 ? 34  TYR H CD1 1 
ATOM   1951 C CD2 . TYR B 2 34  ? 23.869    -20.83    19.079    1     24.29484 ? 34  TYR H CD2 1 
ATOM   1952 C CE1 . TYR B 2 34  ? 22.252    -18.635   18.772    1     20.54288 ? 34  TYR H CE1 1 
ATOM   1953 C CE2 . TYR B 2 34  ? 24.134    -19.685   19.791    1     21.85753 ? 34  TYR H CE2 1 
ATOM   1954 C CZ  . TYR B 2 34  ? 23.322    -18.591   19.634    1     18.21058 ? 34  TYR H CZ  1 
ATOM   1955 O OH  . TYR B 2 34  ? 23.585    -17.46    20.337    1     18.88277 ? 34  TYR H OH  1 
ATOM   1956 N N   . TYR B 2 35  ? 20.432    -23.727   15.492    1     17.72832 ? 35  TYR H N   1 
ATOM   1957 C CA  . TYR B 2 35  ? 20.415    -24.723   14.453    1     20.37904 ? 35  TYR H CA  1 
ATOM   1958 C C   . TYR B 2 35  ? 21.28     -24.234   13.29     1     20.15442 ? 35  TYR H C   1 
ATOM   1959 O O   . TYR B 2 35  ? 21.445    -23.034   13.109    1     15.60443 ? 35  TYR H O   1 
ATOM   1960 C CB  . TYR B 2 35  ? 19.008    -25.085   14.006    1     15.62456 ? 35  TYR H CB  1 
ATOM   1961 C CG  . TYR B 2 35  ? 18.089    -23.962   13.663    1     15.875   ? 35  TYR H CG  1 
ATOM   1962 C CD1 . TYR B 2 35  ? 17.338    -23.342   14.641    1     18.21655 ? 35  TYR H CD1 1 
ATOM   1963 C CD2 . TYR B 2 35  ? 17.919    -23.561   12.351    1     15.44278 ? 35  TYR H CD2 1 
ATOM   1964 C CE1 . TYR B 2 35  ? 16.467    -22.327   14.327    1     15.57945 ? 35  TYR H CE1 1 
ATOM   1965 C CE2 . TYR B 2 35  ? 17.048    -22.549   12.029    1     12.71898 ? 35  TYR H CE2 1 
ATOM   1966 C CZ  . TYR B 2 35  ? 16.326    -21.941   13.023    1     14.81236 ? 35  TYR H CZ  1 
ATOM   1967 O OH  . TYR B 2 35  ? 15.47     -20.936   12.718    1     18.23353 ? 35  TYR H OH  1 
ATOM   1968 N N   . TRP B 2 36  A 21.818    -25.166   12.532    1     16.10734 ? 35  TRP H N   1 
ATOM   1969 C CA  . TRP B 2 36  A 22.711    -24.875   11.442    1     13.05095 ? 35  TRP H CA  1 
ATOM   1970 C C   . TRP B 2 36  A 22.075    -25.332   10.137    1     21.08635 ? 35  TRP H C   1 
ATOM   1971 O O   . TRP B 2 36  A 21.653    -26.483   10.048    1     16.7317  ? 35  TRP H O   1 
ATOM   1972 C CB  . TRP B 2 36  A 24.039    -25.532   11.734    1     13.69058 ? 35  TRP H CB  1 
ATOM   1973 C CG  . TRP B 2 36  A 24.518    -25.159   13.085    1     20.23492 ? 35  TRP H CG  1 
ATOM   1974 C CD1 . TRP B 2 36  A 24.444    -25.905   14.219    1     20.95778 ? 35  TRP H CD1 1 
ATOM   1975 C CD2 . TRP B 2 36  A 25.099    -23.914   13.461    1     17.33323 ? 35  TRP H CD2 1 
ATOM   1976 N NE1 . TRP B 2 36  A 24.966    -25.21    15.277    1     17.14562 ? 35  TRP H NE1 1 
ATOM   1977 C CE2 . TRP B 2 36  A 25.376    -23.982   14.837    1     16.2959  ? 35  TRP H CE2 1 
ATOM   1978 C CE3 . TRP B 2 36  A 25.43     -22.753   12.764    1     15.62991 ? 35  TRP H CE3 1 
ATOM   1979 C CZ2 . TRP B 2 36  A 25.956    -22.93    15.528    1     19.57225 ? 35  TRP H CZ2 1 
ATOM   1980 C CZ3 . TRP B 2 36  A 26.008    -21.715   13.45     1     20.03668 ? 35  TRP H CZ3 1 
ATOM   1981 C CH2 . TRP B 2 36  A 26.265    -21.807   14.818    1     15.48085 ? 35  TRP H CH2 1 
ATOM   1982 N N   . THR B 2 37  B 22.056    -24.466   9.132     1     14.40387 ? 35  THR H N   1 
ATOM   1983 C CA  . THR B 2 37  B 21.322    -24.739   7.915     1     15.81599 ? 35  THR H CA  1 
ATOM   1984 C C   . THR B 2 37  B 22.041    -24.497   6.574     1     20.61574 ? 35  THR H C   1 
ATOM   1985 O O   . THR B 2 37  B 23.002    -23.753   6.509     1     15.42605 ? 35  THR H O   1 
ATOM   1986 C CB  . THR B 2 37  B 20.006    -23.902   7.965     1     19.49694 ? 35  THR H CB  1 
ATOM   1987 O OG1 . THR B 2 37  B 19.179    -24.34    9.046     1     33.21708 ? 35  THR H OG1 1 
ATOM   1988 C CG2 . THR B 2 37  B 19.226    -23.968   6.647     1     22.1561  ? 35  THR H CG2 1 
ATOM   1989 N N   . TRP B 2 38  ? 21.576    -25.151   5.526     1     17.3846  ? 36  TRP H N   1 
ATOM   1990 C CA  . TRP B 2 38  ? 22.121    -24.944   4.208     1     15.19814 ? 36  TRP H CA  1 
ATOM   1991 C C   . TRP B 2 38  ? 20.988    -24.582   3.24      1     17.74948 ? 36  TRP H C   1 
ATOM   1992 O O   . TRP B 2 38  ? 19.917    -25.152   3.303     1     18.95449 ? 36  TRP H O   1 
ATOM   1993 C CB  . TRP B 2 38  ? 22.862    -26.165   3.721     1     12.54548 ? 36  TRP H CB  1 
ATOM   1994 C CG  . TRP B 2 38  ? 24.175    -26.443   4.361     1     17.64433 ? 36  TRP H CG  1 
ATOM   1995 C CD1 . TRP B 2 38  ? 24.418    -27.286   5.395     1     14.02446 ? 36  TRP H CD1 1 
ATOM   1996 C CD2 . TRP B 2 38  ? 25.438    -25.9     3.982     1     15.45372 ? 36  TRP H CD2 1 
ATOM   1997 N NE1 . TRP B 2 38  ? 25.752    -27.295   5.696     1     15.23431 ? 36  TRP H NE1 1 
ATOM   1998 C CE2 . TRP B 2 38  ? 26.401    -26.446   4.844     1     12.8219  ? 36  TRP H CE2 1 
ATOM   1999 C CE3 . TRP B 2 38  ? 25.847    -24.988   3.008     1     14.53411 ? 36  TRP H CE3 1 
ATOM   2000 C CZ2 . TRP B 2 38  ? 27.743    -26.116   4.761     1     16.5134  ? 36  TRP H CZ2 1 
ATOM   2001 C CZ3 . TRP B 2 38  ? 27.179    -24.665   2.927     1     18.24903 ? 36  TRP H CZ3 1 
ATOM   2002 C CH2 . TRP B 2 38  ? 28.113    -25.229   3.795     1     14.97951 ? 36  TRP H CH2 1 
ATOM   2003 N N   . ILE B 2 39  ? 21.222    -23.643   2.364     1     13.56743 ? 37  ILE H N   1 
ATOM   2004 C CA  . ILE B 2 39  ? 20.259    -23.264   1.36      1     9.96589  ? 37  ILE H CA  1 
ATOM   2005 C C   . ILE B 2 39  ? 21.01     -23.087   0.027     1     16.01895 ? 37  ILE H C   1 
ATOM   2006 O O   . ILE B 2 39  ? 22.188    -22.802   0.02      1     13.17812 ? 37  ILE H O   1 
ATOM   2007 C CB  . ILE B 2 39  ? 19.509    -21.969   1.69      1     16.05327 ? 37  ILE H CB  1 
ATOM   2008 C CG1 . ILE B 2 39  ? 18.939    -21.991   3.115     1     17.64103 ? 37  ILE H CG1 1 
ATOM   2009 C CG2 . ILE B 2 39  ? 18.415    -21.686   0.668     1     22.93453 ? 37  ILE H CG2 1 
ATOM   2010 C CD1 . ILE B 2 39  ? 19.869    -21.394   4.146     1     19.9932  ? 37  ILE H CD1 1 
ATOM   2011 N N   . ARG B 2 40  ? 20.32     -23.264   -1.082    1     13.39429 ? 38  ARG H N   1 
ATOM   2012 C CA  . ARG B 2 40  ? 20.941    -23.091   -2.393    1     19.25929 ? 38  ARG H CA  1 
ATOM   2013 C C   . ARG B 2 40  ? 20.135    -22.301   -3.414    1     20.27867 ? 38  ARG H C   1 
ATOM   2014 O O   . ARG B 2 40  ? 18.914    -22.254   -3.34     1     18.26816 ? 38  ARG H O   1 
ATOM   2015 C CB  . ARG B 2 40  ? 21.351    -24.43    -3.023    1     12.11396 ? 38  ARG H CB  1 
ATOM   2016 C CG  . ARG B 2 40  ? 20.225    -25.306   -3.519    1     20.48837 ? 38  ARG H CG  1 
ATOM   2017 C CD  . ARG B 2 40  ? 20.787    -26.594   -4.097    1     16.11308 ? 38  ARG H CD  1 
ATOM   2018 N NE  . ARG B 2 40  ? 19.766    -27.401   -4.742    1     22.06376 ? 38  ARG H NE  1 
ATOM   2019 C CZ  . ARG B 2 40  ? 19.992    -28.561   -5.342    1     22.60936 ? 38  ARG H CZ  1 
ATOM   2020 N NH1 . ARG B 2 40  ? 21.211    -29.063   -5.388    1     17.20451 ? 38  ARG H NH1 1 
ATOM   2021 N NH2 . ARG B 2 40  ? 18.993    -29.213   -5.902    1     19.56676 ? 38  ARG H NH2 1 
ATOM   2022 N N   . GLN B 2 41  ? 20.835    -21.692   -4.351    1     17.54268 ? 39  GLN H N   1 
ATOM   2023 C CA  . GLN B 2 41  ? 20.198    -20.96    -5.424    1     19.06766 ? 39  GLN H CA  1 
ATOM   2024 C C   . GLN B 2 41  ? 20.838    -21.32    -6.751    1     16.92234 ? 39  GLN H C   1 
ATOM   2025 O O   . GLN B 2 41  ? 21.962    -20.962   -7.014    1     16.38321 ? 39  GLN H O   1 
ATOM   2026 C CB  . GLN B 2 41  ? 20.31     -19.469   -5.21     1     23.51726 ? 39  GLN H CB  1 
ATOM   2027 C CG  . GLN B 2 41  ? 19.696    -18.628   -6.304    1     23.11551 ? 39  GLN H CG  1 
ATOM   2028 C CD  . GLN B 2 41  ? 19.432    -17.215   -5.84     1     27.2498  ? 39  GLN H CD  1 
ATOM   2029 O OE1 . GLN B 2 41  ? 18.331    -16.708   -5.978    1     29.66672 ? 39  GLN H OE1 1 
ATOM   2030 N NE2 . GLN B 2 41  ? 20.435    -16.587   -5.265    1     17.91517 ? 39  GLN H NE2 1 
ATOM   2031 N N   . PRO B 2 42  ? 20.11     -22.073   -7.551    1     21.32598 ? 40  PRO H N   1 
ATOM   2032 C CA  . PRO B 2 42  ? 20.625    -22.363   -8.888    1     22.64681 ? 40  PRO H CA  1 
ATOM   2033 C C   . PRO B 2 42  ? 20.62     -21.091   -9.719    1     22.26665 ? 40  PRO H C   1 
ATOM   2034 O O   . PRO B 2 42  ? 19.875    -20.176   -9.452    1     19.38467 ? 40  PRO H O   1 
ATOM   2035 C CB  . PRO B 2 42  ? 19.635    -23.363   -9.443    1     24.40221 ? 40  PRO H CB  1 
ATOM   2036 C CG  . PRO B 2 42  ? 18.903    -23.906   -8.266    1     22.80389 ? 40  PRO H CG  1 
ATOM   2037 C CD  . PRO B 2 42  ? 18.878    -22.811   -7.254    1     21.27069 ? 40  PRO H CD  1 
ATOM   2038 N N   . PRO B 2 43  ? 21.495    -21.042   -10.707   1     26.84625 ? 41  PRO H N   1 
ATOM   2039 C CA  . PRO B 2 43  ? 21.58     -19.846   -11.55    1     30.84354 ? 41  PRO H CA  1 
ATOM   2040 C C   . PRO B 2 43  ? 20.248    -19.492   -12.208   1     23.59061 ? 41  PRO H C   1 
ATOM   2041 O O   . PRO B 2 43  ? 19.59     -20.318   -12.797   1     22.70302 ? 41  PRO H O   1 
ATOM   2042 C CB  . PRO B 2 43  ? 22.652    -20.23    -12.575   1     36.5919  ? 41  PRO H CB  1 
ATOM   2043 C CG  . PRO B 2 43  ? 23.441    -21.305   -11.923   1     28.88271 ? 41  PRO H CG  1 
ATOM   2044 C CD  . PRO B 2 43  ? 22.448    -22.078   -11.122   1     23.85756 ? 41  PRO H CD  1 
ATOM   2045 N N   . GLY B 2 44  ? 19.838    -18.251   -12.033   1     31.6369  ? 42  GLY H N   1 
ATOM   2046 C CA  . GLY B 2 44  ? 18.579    -17.792   -12.595   1     34.45888 ? 42  GLY H CA  1 
ATOM   2047 C C   . GLY B 2 44  ? 17.332    -18.31    -11.936   1     34.42008 ? 42  GLY H C   1 
ATOM   2048 O O   . GLY B 2 44  ? 16.257    -18.206   -12.485   1     43.10875 ? 42  GLY H O   1 
ATOM   2049 N N   . LYS B 2 45  ? 17.484    -18.895   -10.768   1     34.12378 ? 43  LYS H N   1 
ATOM   2050 C CA  . LYS B 2 45  ? 16.344    -19.414   -10.048   1     28.06629 ? 43  LYS H CA  1 
ATOM   2051 C C   . LYS B 2 45  ? 16.305    -18.85    -8.631    1     29.56097 ? 43  LYS H C   1 
ATOM   2052 O O   . LYS B 2 45  ? 17.124    -18.04    -8.254    1     31.68976 ? 43  LYS H O   1 
ATOM   2053 C CB  . LYS B 2 45  ? 16.343    -20.934   -10.084   1     25.29984 ? 43  LYS H CB  1 
ATOM   2054 C CG  . LYS B 2 45  ? 16.068    -21.528   -11.448   1     36.47751 ? 43  LYS H CG  1 
ATOM   2055 C CD  . LYS B 2 45  ? 16.376    -23.015   -11.48    1     43.64169 ? 43  LYS H CD  1 
ATOM   2056 C CE  . LYS B 2 45  ? 15.124    -23.862   -11.664   1     55.01746 ? 43  LYS H CE  1 
ATOM   2057 N NZ  . LYS B 2 45  ? 14.231    -23.858   -10.473   1     57.40391 ? 43  LYS H NZ  1 
ATOM   2058 N N   . GLY B 2 46  ? 15.321    -19.265   -7.866    1     31.00895 ? 44  GLY H N   1 
ATOM   2059 C CA  . GLY B 2 46  ? 15.193    -18.787   -6.519    1     31.06589 ? 44  GLY H CA  1 
ATOM   2060 C C   . GLY B 2 46  ? 15.88     -19.606   -5.472    1     30.83671 ? 44  GLY H C   1 
ATOM   2061 O O   . GLY B 2 46  ? 16.79     -20.348   -5.764    1     31.26252 ? 44  GLY H O   1 
ATOM   2062 N N   . LEU B 2 47  ? 15.411    -19.489   -4.254    1     31.19731 ? 45  LEU H N   1 
ATOM   2063 C CA  . LEU B 2 47  ? 16.038    -20.175   -3.163    1     25.64618 ? 45  LEU H CA  1 
ATOM   2064 C C   . LEU B 2 47  ? 15.417    -21.523   -2.791    1     27.04731 ? 45  LEU H C   1 
ATOM   2065 O O   . LEU B 2 47  ? 14.219    -21.661   -2.773    1     25.09066 ? 45  LEU H O   1 
ATOM   2066 C CB  . LEU B 2 47  ? 16.09     -19.236   -1.972    1     20.8848  ? 45  LEU H CB  1 
ATOM   2067 C CG  . LEU B 2 47  ? 16.884    -17.95    -2.166    1     25.33504 ? 45  LEU H CG  1 
ATOM   2068 C CD1 . LEU B 2 47  ? 16.494    -16.895   -1.147    1     22.98198 ? 45  LEU H CD1 1 
ATOM   2069 C CD2 . LEU B 2 47  ? 18.374    -18.221   -2.14     1     25.92499 ? 45  LEU H CD2 1 
ATOM   2070 N N   . GLU B 2 48  ? 16.264    -22.506   -2.549    1     23.48181 ? 46  GLU H N   1 
ATOM   2071 C CA  . GLU B 2 48  ? 15.814    -23.826   -2.133    1     22.87828 ? 46  GLU H CA  1 
ATOM   2072 C C   . GLU B 2 48  ? 16.441    -24.281   -0.821    1     18.43361 ? 46  GLU H C   1 
ATOM   2073 O O   . GLU B 2 48  ? 17.628    -24.35    -0.69     1     19.92109 ? 46  GLU H O   1 
ATOM   2074 C CB  . GLU B 2 48  ? 16.079    -24.882   -3.215    1     25.19866 ? 46  GLU H CB  1 
ATOM   2075 C CG  . GLU B 2 48  ? 15.815    -26.314   -2.772    1     28.13452 ? 46  GLU H CG  1 
ATOM   2076 C CD  . GLU B 2 48  ? 16.056    -27.343   -3.865    1     35.27956 ? 46  GLU H CD  1 
ATOM   2077 O OE1 . GLU B 2 48  ? 16.972    -27.162   -4.685    1     26.56966 ? 46  GLU H OE1 1 
ATOM   2078 O OE2 . GLU B 2 48  ? 15.33     -28.354   -3.885    1     37.50072 ? 46  GLU H OE2 1 
ATOM   2079 N N   . TRP B 2 49  ? 15.604    -24.561   0.135     1     20.58362 ? 47  TRP H N   1 
ATOM   2080 C CA  . TRP B 2 49  ? 16.059    -25.036   1.422     1     26.16482 ? 47  TRP H CA  1 
ATOM   2081 C C   . TRP B 2 49  ? 16.513    -26.494   1.366     1     22.56252 ? 47  TRP H C   1 
ATOM   2082 O O   . TRP B 2 49  ? 15.823    -27.318   0.825     1     18.18333 ? 47  TRP H O   1 
ATOM   2083 C CB  . TRP B 2 49  ? 14.942    -24.821   2.436     1     22.04212 ? 47  TRP H CB  1 
ATOM   2084 C CG  . TRP B 2 49  ? 15.237    -25.13    3.85      1     23.5256  ? 47  TRP H CG  1 
ATOM   2085 C CD1 . TRP B 2 49  ? 15.786    -24.297   4.77      1     21.05715 ? 47  TRP H CD1 1 
ATOM   2086 C CD2 . TRP B 2 49  ? 14.945    -26.347   4.533     1     19.19189 ? 47  TRP H CD2 1 
ATOM   2087 N NE1 . TRP B 2 49  ? 15.874    -24.924   5.981     1     22.89856 ? 47  TRP H NE1 1 
ATOM   2088 C CE2 . TRP B 2 49  ? 15.363    -26.187   5.862     1     27.94388 ? 47  TRP H CE2 1 
ATOM   2089 C CE3 . TRP B 2 49  ? 14.379    -27.561   4.147     1     24.94397 ? 47  TRP H CE3 1 
ATOM   2090 C CZ2 . TRP B 2 49  ? 15.235    -27.193   6.806     1     28.99668 ? 47  TRP H CZ2 1 
ATOM   2091 C CZ3 . TRP B 2 49  ? 14.25     -28.555   5.082     1     27.46946 ? 47  TRP H CZ3 1 
ATOM   2092 C CH2 . TRP B 2 49  ? 14.677    -28.368   6.398     1     30.80986 ? 47  TRP H CH2 1 
ATOM   2093 N N   . ILE B 2 50  ? 17.676    -26.767   1.926     1     14.89085 ? 48  ILE H N   1 
ATOM   2094 C CA  . ILE B 2 50  ? 18.218    -28.115   1.914     1     14.55378 ? 48  ILE H CA  1 
ATOM   2095 C C   . ILE B 2 50  ? 17.971    -28.826   3.224     1     21.03038 ? 48  ILE H C   1 
ATOM   2096 O O   . ILE B 2 50  ? 17.606    -29.976   3.237     1     20.9022  ? 48  ILE H O   1 
ATOM   2097 C CB  . ILE B 2 50  ? 19.723    -28.111   1.571     1     17.70936 ? 48  ILE H CB  1 
ATOM   2098 C CG1 . ILE B 2 50  ? 19.941    -27.475   0.197     1     22.91683 ? 48  ILE H CG1 1 
ATOM   2099 C CG2 . ILE B 2 50  ? 20.297    -29.514   1.627     1     16.2872  ? 48  ILE H CG2 1 
ATOM   2100 C CD1 . ILE B 2 50  ? 21.369    -27.085   -0.088    1     15.45414 ? 48  ILE H CD1 1 
ATOM   2101 N N   . GLY B 2 51  ? 18.205    -28.125   4.325     1     24.75072 ? 49  GLY H N   1 
ATOM   2102 C CA  . GLY B 2 51  ? 17.97     -28.684   5.632     1     22.83936 ? 49  GLY H CA  1 
ATOM   2103 C C   . GLY B 2 51  ? 18.67     -28.081   6.825     1     20.92939 ? 49  GLY H C   1 
ATOM   2104 O O   . GLY B 2 51  ? 19.378    -27.113   6.686     1     21.04052 ? 49  GLY H O   1 
ATOM   2105 N N   . TYR B 2 52  ? 18.425    -28.637   7.991     1     18.37045 ? 50  TYR H N   1 
ATOM   2106 C CA  . TYR B 2 52  ? 19.038    -28.159   9.203     1     19.16586 ? 50  TYR H CA  1 
ATOM   2107 C C   . TYR B 2 52  ? 19.588    -29.259   10.082    1     19.12933 ? 50  TYR H C   1 
ATOM   2108 O O   . TYR B 2 52  ? 19.184    -30.406   9.96      1     20.54634 ? 50  TYR H O   1 
ATOM   2109 C CB  . TYR B 2 52  ? 18.046    -27.331   10.005    1     19.11    ? 50  TYR H CB  1 
ATOM   2110 C CG  . TYR B 2 52  ? 16.932    -28.09    10.688    1     24.20666 ? 50  TYR H CG  1 
ATOM   2111 C CD1 . TYR B 2 52  ? 17.179    -28.868   11.806    1     24.46274 ? 50  TYR H CD1 1 
ATOM   2112 C CD2 . TYR B 2 52  ? 15.624    -27.988   10.241    1     25.42752 ? 50  TYR H CD2 1 
ATOM   2113 C CE1 . TYR B 2 52  ? 16.163    -29.549   12.437    1     27.39625 ? 50  TYR H CE1 1 
ATOM   2114 C CE2 . TYR B 2 52  ? 14.6      -28.661   10.871    1     20.95951 ? 50  TYR H CE2 1 
ATOM   2115 C CZ  . TYR B 2 52  ? 14.877    -29.44    11.966    1     26.80887 ? 50  TYR H CZ  1 
ATOM   2116 O OH  . TYR B 2 52  ? 13.872    -30.108   12.6      1     33.91817 ? 50  TYR H OH  1 
ATOM   2117 N N   . ILE B 2 53  ? 20.48     -28.888   10.978    1     16.24671 ? 51  ILE H N   1 
ATOM   2118 C CA  . ILE B 2 53  ? 21.05     -29.82    11.899    1     17.99643 ? 51  ILE H CA  1 
ATOM   2119 C C   . ILE B 2 53  ? 21.293    -29.199   13.272    1     20.76422 ? 51  ILE H C   1 
ATOM   2120 O O   . ILE B 2 53  ? 21.754    -28.071   13.349    1     19.34552 ? 51  ILE H O   1 
ATOM   2121 C CB  . ILE B 2 53  ? 22.372    -30.438   11.364    1     20.81516 ? 51  ILE H CB  1 
ATOM   2122 C CG1 . ILE B 2 53  ? 22.905    -31.473   12.361    1     18.39418 ? 51  ILE H CG1 1 
ATOM   2123 C CG2 . ILE B 2 53  ? 23.404    -29.366   11.062    1     15.32179 ? 51  ILE H CG2 1 
ATOM   2124 C CD1 . ILE B 2 53  ? 24.023    -32.336   11.829    1     15.35693 ? 51  ILE H CD1 1 
ATOM   2125 N N   . PHE B 2 54  ? 20.946    -29.916   14.325    1     17.73241 ? 52  PHE H N   1 
ATOM   2126 C CA  . PHE B 2 54  ? 21.208    -29.488   15.676    1     22.97971 ? 52  PHE H CA  1 
ATOM   2127 C C   . PHE B 2 54  ? 22.3      -30.4     16.235    1     24.28719 ? 52  PHE H C   1 
ATOM   2128 O O   . PHE B 2 54  ? 22.391    -31.544   15.85     1     20.13324 ? 52  PHE H O   1 
ATOM   2129 C CB  . PHE B 2 54  ? 19.971    -29.617   16.563    1     27.73708 ? 52  PHE H CB  1 
ATOM   2130 C CG  . PHE B 2 54  ? 18.923    -28.562   16.371    1     23.21634 ? 52  PHE H CG  1 
ATOM   2131 C CD1 . PHE B 2 54  ? 17.938    -28.712   15.423    1     19.36682 ? 52  PHE H CD1 1 
ATOM   2132 C CD2 . PHE B 2 54  ? 18.879    -27.46    17.203    1     24.75719 ? 52  PHE H CD2 1 
ATOM   2133 C CE1 . PHE B 2 54  ? 16.953    -27.761   15.272    1     26.32821 ? 52  PHE H CE1 1 
ATOM   2134 C CE2 . PHE B 2 54  ? 17.898    -26.504   17.058    1     22.49637 ? 52  PHE H CE2 1 
ATOM   2135 C CZ  . PHE B 2 54  ? 16.929    -26.656   16.093    1     23.0064  ? 52  PHE H CZ  1 
ATOM   2136 N N   . TYR B 2 55  ? 23.114    -29.906   17.143    1     17.30291 ? 53  TYR H N   1 
ATOM   2137 C CA  . TYR B 2 55  ? 24.11     -30.738   17.776    1     20.71357 ? 53  TYR H CA  1 
ATOM   2138 C C   . TYR B 2 55  ? 23.451    -31.864   18.581    1     21.7375  ? 53  TYR H C   1 
ATOM   2139 O O   . TYR B 2 55  ? 24.016    -32.909   18.716    1     22.46146 ? 53  TYR H O   1 
ATOM   2140 C CB  . TYR B 2 55  ? 25.055    -29.945   18.672    1     19.5051  ? 53  TYR H CB  1 
ATOM   2141 C CG  . TYR B 2 55  ? 26.087    -30.828   19.306    1     21.88211 ? 53  TYR H CG  1 
ATOM   2142 C CD1 . TYR B 2 55  ? 27.136    -31.338   18.561    1     22.71287 ? 53  TYR H CD1 1 
ATOM   2143 C CD2 . TYR B 2 55  ? 25.99     -31.193   20.635    1     21.86811 ? 53  TYR H CD2 1 
ATOM   2144 C CE1 . TYR B 2 55  ? 28.072    -32.171   19.126    1     23.00476 ? 53  TYR H CE1 1 
ATOM   2145 C CE2 . TYR B 2 55  ? 26.921    -32.026   21.211    1     22.52345 ? 53  TYR H CE2 1 
ATOM   2146 C CZ  . TYR B 2 55  ? 27.96     -32.511   20.449    1     30.30802 ? 53  TYR H CZ  1 
ATOM   2147 O OH  . TYR B 2 55  ? 28.885    -33.341   21.01     1     28.72072 ? 53  TYR H OH  1 
ATOM   2148 N N   . ASN B 2 56  ? 22.255    -31.619   19.082    1     24.63967 ? 54  ASN H N   1 
ATOM   2149 C CA  . ASN B 2 56  ? 21.524    -32.598   19.862    1     29.90754 ? 54  ASN H CA  1 
ATOM   2150 C C   . ASN B 2 56  ? 21.066    -33.805   19.045    1     33.07259 ? 54  ASN H C   1 
ATOM   2151 O O   . ASN B 2 56  ? 20.429    -34.685   19.58     1     33.16024 ? 54  ASN H O   1 
ATOM   2152 C CB  . ASN B 2 56  ? 20.336    -31.916   20.525    1     29.50332 ? 54  ASN H CB  1 
ATOM   2153 C CG  . ASN B 2 56  ? 19.319    -31.41    19.545    1     29.73122 ? 54  ASN H CG  1 
ATOM   2154 O OD1 . ASN B 2 56  ? 18.914    -32.115   18.636    1     35.96767 ? 54  ASN H OD1 1 
ATOM   2155 N ND2 . ASN B 2 56  ? 18.879    -30.183   19.746    1     37.71854 ? 54  ASN H ND2 1 
ATOM   2156 N N   . GLY B 2 57  ? 21.391    -33.832   17.765    1     24.39906 ? 55  GLY H N   1 
ATOM   2157 C CA  . GLY B 2 57  ? 21.002    -34.929   16.903    1     27.46863 ? 55  GLY H CA  1 
ATOM   2158 C C   . GLY B 2 57  ? 19.781    -34.657   16.055    1     25.59804 ? 55  GLY H C   1 
ATOM   2159 O O   . GLY B 2 57  ? 19.448    -35.473   15.187    1     33.5546  ? 55  GLY H O   1 
ATOM   2160 N N   . ASP B 2 58  ? 19.116    -33.532   16.28     1     27.64169 ? 56  ASP H N   1 
ATOM   2161 C CA  . ASP B 2 58  ? 17.9      -33.187   15.559    1     25.62084 ? 56  ASP H CA  1 
ATOM   2162 C C   . ASP B 2 58  ? 18.239    -32.679   14.159    1     31.04375 ? 56  ASP H C   1 
ATOM   2163 O O   . ASP B 2 58  ? 18.937    -31.67    14.006    1     23.92475 ? 56  ASP H O   1 
ATOM   2164 C CB  . ASP B 2 58  ? 17.132    -32.139   16.361    1     38.06546 ? 56  ASP H CB  1 
ATOM   2165 C CG  . ASP B 2 58  ? 15.736    -31.927   15.864    1     46.28564 ? 56  ASP H CG  1 
ATOM   2166 O OD1 . ASP B 2 58  ? 15.345    -32.578   14.882    1     60.80049 ? 56  ASP H OD1 1 
ATOM   2167 O OD2 . ASP B 2 58  ? 15.035    -31.065   16.435    1     57.02731 ? 56  ASP H OD2 1 
ATOM   2168 N N   . THR B 2 59  ? 17.712    -33.374   13.154    1     28.38313 ? 57  THR H N   1 
ATOM   2169 C CA  . THR B 2 59  ? 17.936    -33.011   11.768    1     28.5987  ? 57  THR H CA  1 
ATOM   2170 C C   . THR B 2 59  ? 16.687    -33.131   10.911    1     30.85584 ? 57  THR H C   1 
ATOM   2171 O O   . THR B 2 59  ? 15.794    -33.892   11.237    1     27.00455 ? 57  THR H O   1 
ATOM   2172 C CB  . THR B 2 59  ? 19.008    -33.914   11.101    1     32.6037  ? 57  THR H CB  1 
ATOM   2173 O OG1 . THR B 2 59  ? 18.455    -35.204   10.83     1     32.96294 ? 57  THR H OG1 1 
ATOM   2174 C CG2 . THR B 2 59  ? 20.229    -34.058   11.983    1     29.51166 ? 57  THR H CG2 1 
ATOM   2175 N N   . ASN B 2 60  ? 16.622    -32.374   9.826     1     21.87845 ? 58  ASN H N   1 
ATOM   2176 C CA  . ASN B 2 60  ? 15.529    -32.473   8.89      1     21.89294 ? 58  ASN H CA  1 
ATOM   2177 C C   . ASN B 2 60  ? 16.023    -32.001   7.535     1     28.04955 ? 58  ASN H C   1 
ATOM   2178 O O   . ASN B 2 60  ? 16.567    -30.93    7.431     1     23.20981 ? 58  ASN H O   1 
ATOM   2179 C CB  . ASN B 2 60  ? 14.291    -31.674   9.305     1     22.01354 ? 58  ASN H CB  1 
ATOM   2180 C CG  . ASN B 2 60  ? 13.176    -31.767   8.285     1     34.52811 ? 58  ASN H CG  1 
ATOM   2181 O OD1 . ASN B 2 60  ? 13.18     -31.072   7.277     1     36.94743 ? 58  ASN H OD1 1 
ATOM   2182 N ND2 . ASN B 2 60  ? 12.223    -32.642   8.539     1     40.41217 ? 58  ASN H ND2 1 
ATOM   2183 N N   . TYR B 2 61  ? 15.833    -32.815   6.515     1     22.05488 ? 59  TYR H N   1 
ATOM   2184 C CA  . TYR B 2 61  ? 16.227    -32.435   5.179     1     22.20857 ? 59  TYR H CA  1 
ATOM   2185 C C   . TYR B 2 61  ? 15.038    -32.344   4.243     1     21.55767 ? 59  TYR H C   1 
ATOM   2186 O O   . TYR B 2 61  ? 14.034    -32.99    4.441     1     26.66923 ? 59  TYR H O   1 
ATOM   2187 C CB  . TYR B 2 61  ? 17.278    -33.406   4.629     1     21.50449 ? 59  TYR H CB  1 
ATOM   2188 C CG  . TYR B 2 61  ? 18.448    -33.705   5.532     1     23.36638 ? 59  TYR H CG  1 
ATOM   2189 C CD1 . TYR B 2 61  ? 19.046    -32.714   6.292     1     24.51739 ? 59  TYR H CD1 1 
ATOM   2190 C CD2 . TYR B 2 61  ? 18.974    -34.98    5.596     1     22.34571 ? 59  TYR H CD2 1 
ATOM   2191 C CE1 . TYR B 2 61  ? 20.122    -32.994   7.106     1     22.40537 ? 59  TYR H CE1 1 
ATOM   2192 C CE2 . TYR B 2 61  ? 20.044    -35.269   6.408     1     23.47141 ? 59  TYR H CE2 1 
ATOM   2193 C CZ  . TYR B 2 61  ? 20.614    -34.276   7.161     1     20.63269 ? 59  TYR H CZ  1 
ATOM   2194 O OH  . TYR B 2 61  ? 21.676    -34.569   7.963     1     23.90654 ? 59  TYR H OH  1 
ATOM   2195 N N   . ASN B 2 62  ? 15.167    -31.536   3.222     1     19.16103 ? 60  ASN H N   1 
ATOM   2196 C CA  . ASN B 2 62  ? 14.115    -31.375   2.273     1     23.17563 ? 60  ASN H CA  1 
ATOM   2197 C C   . ASN B 2 62  ? 13.844    -32.709   1.565     1     24.77376 ? 60  ASN H C   1 
ATOM   2198 O O   . ASN B 2 62  ? 14.742    -33.324   1.023     1     25.35832 ? 60  ASN H O   1 
ATOM   2199 C CB  . ASN B 2 62  ? 14.475    -30.268   1.281     1     15.84567 ? 60  ASN H CB  1 
ATOM   2200 C CG  . ASN B 2 62  ? 13.308    -29.823   0.429     1     27.28937 ? 60  ASN H CG  1 
ATOM   2201 O OD1 . ASN B 2 62  ? 12.375    -30.573   0.186     1     26.50498 ? 60  ASN H OD1 1 
ATOM   2202 N ND2 . ASN B 2 62  ? 13.373    -28.589   -0.048    1     22.63376 ? 60  ASN H ND2 1 
ATOM   2203 N N   . PRO B 2 63  ? 12.59     -33.135   1.578     1     26.3143  ? 61  PRO H N   1 
ATOM   2204 C CA  . PRO B 2 63  ? 12.233    -34.4     0.928     1     28.38545 ? 61  PRO H CA  1 
ATOM   2205 C C   . PRO B 2 63  ? 12.668    -34.433   -0.522    1     25.20542 ? 61  PRO H C   1 
ATOM   2206 O O   . PRO B 2 63  ? 12.924    -35.487   -1.043    1     32.17356 ? 61  PRO H O   1 
ATOM   2207 C CB  . PRO B 2 63  ? 10.725    -34.425   1.055     1     27.76376 ? 61  PRO H CB  1 
ATOM   2208 C CG  . PRO B 2 63  ? 10.43     -33.629   2.272     1     31.62309 ? 61  PRO H CG  1 
ATOM   2209 C CD  . PRO B 2 63  ? 11.459    -32.544   2.307     1     27.27231 ? 61  PRO H CD  1 
ATOM   2210 N N   . SER B 2 64  ? 12.768    -33.289   -1.155    1     27.915   ? 62  SER H N   1 
ATOM   2211 C CA  . SER B 2 64  ? 13.256    -33.206   -2.514    1     27.1332  ? 62  SER H CA  1 
ATOM   2212 C C   . SER B 2 64  ? 14.685    -33.708   -2.655    1     36.13749 ? 62  SER H C   1 
ATOM   2213 O O   . SER B 2 64  ? 15.108    -34.043   -3.745    1     34.35943 ? 62  SER H O   1 
ATOM   2214 C CB  . SER B 2 64  ? 13.196    -31.751   -2.966    1     27.47129 ? 62  SER H CB  1 
ATOM   2215 O OG  . SER B 2 64  ? 14.063    -30.937   -2.216    1     31.71263 ? 62  SER H OG  1 
ATOM   2216 N N   . LEU B 2 65  ? 15.431    -33.733   -1.565    1     30.45571 ? 63  LEU H N   1 
ATOM   2217 C CA  . LEU B 2 65  ? 16.822    -34.141   -1.598    1     32.02399 ? 63  LEU H CA  1 
ATOM   2218 C C   . LEU B 2 65  ? 17.23     -35.035   -0.433    1     34.59828 ? 63  LEU H C   1 
ATOM   2219 O O   . LEU B 2 65  ? 18.411    -35.33    -0.3      1     37.35482 ? 63  LEU H O   1 
ATOM   2220 C CB  . LEU B 2 65  ? 17.673    -32.89    -1.503    1     27.75    ? 63  LEU H CB  1 
ATOM   2221 C CG  . LEU B 2 65  ? 17.363    -31.688   -2.389    1     36.5151  ? 63  LEU H CG  1 
ATOM   2222 C CD1 . LEU B 2 65  ? 17.836    -30.4     -1.738    1     26.84756 ? 63  LEU H CD1 1 
ATOM   2223 C CD2 . LEU B 2 65  ? 17.964    -31.859   -3.772    1     32.01345 ? 63  LEU H CD2 1 
ATOM   2224 N N   . LYS B 2 66  ? 16.291    -35.492   0.39      1     29.12497 ? 64  LYS H N   1 
ATOM   2225 C CA  . LYS B 2 66  ? 16.637    -36.225   1.615     1     33.53112 ? 64  LYS H CA  1 
ATOM   2226 C C   . LYS B 2 66  ? 17.602    -37.387   1.442     1     35.49942 ? 64  LYS H C   1 
ATOM   2227 O O   . LYS B 2 66  ? 18.591    -37.467   2.152     1     27.23881 ? 64  LYS H O   1 
ATOM   2228 C CB  . LYS B 2 66  ? 15.36     -36.706   2.331     1     35.4896  ? 64  LYS H CB  1 
ATOM   2229 C CG  . LYS B 2 66  ? 15.592    -37.253   3.726     1     34.77214 ? 64  LYS H CG  1 
ATOM   2230 C CD  . LYS B 2 66  ? 14.283    -37.574   4.43      1     40.87547 ? 64  LYS H CD  1 
ATOM   2231 C CE  . LYS B 2 66  ? 13.464    -36.326   4.705     1     48.737   ? 64  LYS H CE  1 
ATOM   2232 N NZ  . LYS B 2 66  ? 12.223    -36.604   5.472     1     43.76902 ? 64  LYS H NZ  1 
ATOM   2233 N N   . SER B 2 67  ? 17.325    -38.251   0.481     1     27.7788  ? 65  SER H N   1 
ATOM   2234 C CA  . SER B 2 67  ? 18.156    -39.411   0.239     1     27.31902 ? 65  SER H CA  1 
ATOM   2235 C C   . SER B 2 67  ? 19.598    -39.062   -0.112    1     25.52073 ? 65  SER H C   1 
ATOM   2236 O O   . SER B 2 67  ? 20.477    -39.857   0.119     1     23.32595 ? 65  SER H O   1 
ATOM   2237 C CB  . SER B 2 67  ? 17.542    -40.236   -0.906    1     28.54832 ? 65  SER H CB  1 
ATOM   2238 O OG  . SER B 2 67  ? 17.563    -39.536   -2.129    1     37.07688 ? 65  SER H OG  1 
ATOM   2239 N N   . ARG B 2 68  ? 19.824    -37.907   -0.705    1     18.17167 ? 66  ARG H N   1 
ATOM   2240 C CA  . ARG B 2 68  ? 21.159    -37.542   -1.139    1     21.54496 ? 66  ARG H CA  1 
ATOM   2241 C C   . ARG B 2 68  ? 21.931    -36.653   -0.17     1     17.01666 ? 66  ARG H C   1 
ATOM   2242 O O   . ARG B 2 68  ? 23.115    -36.443   -0.337    1     18.61454 ? 66  ARG H O   1 
ATOM   2243 C CB  . ARG B 2 68  ? 21.058    -36.845   -2.491    1     24.53493 ? 66  ARG H CB  1 
ATOM   2244 C CG  . ARG B 2 68  ? 20.453    -37.673   -3.609    1     31.69942 ? 66  ARG H CG  1 
ATOM   2245 C CD  . ARG B 2 68  ? 20.769    -37.079   -4.973    1     31.73711 ? 66  ARG H CD  1 
ATOM   2246 N NE  . ARG B 2 68  ? 20.093    -35.816   -5.241    1     23.0398  ? 66  ARG H NE  1 
ATOM   2247 C CZ  . ARG B 2 68  ? 20.692    -34.734   -5.724    1     21.75954 ? 66  ARG H CZ  1 
ATOM   2248 N NH1 . ARG B 2 68  ? 21.987    -34.744   -5.981    1     17.44838 ? 66  ARG H NH1 1 
ATOM   2249 N NH2 . ARG B 2 68  ? 19.993    -33.638   -5.946    1     20.67661 ? 66  ARG H NH2 1 
ATOM   2250 N N   . VAL B 2 69  ? 21.261    -36.16    0.844     1     18.86466 ? 67  VAL H N   1 
ATOM   2251 C CA  . VAL B 2 69  ? 21.869    -35.222   1.745     1     20.96186 ? 67  VAL H CA  1 
ATOM   2252 C C   . VAL B 2 69  ? 22.301    -35.763   3.084     1     22.1443  ? 67  VAL H C   1 
ATOM   2253 O O   . VAL B 2 69  ? 21.59     -36.512   3.715     1     20.10586 ? 67  VAL H O   1 
ATOM   2254 C CB  . VAL B 2 69  ? 20.91     -34.039   2         1     20.85413 ? 67  VAL H CB  1 
ATOM   2255 C CG1 . VAL B 2 69  ? 21.289    -33.269   3.254     1     21.15169 ? 67  VAL H CG1 1 
ATOM   2256 C CG2 . VAL B 2 69  ? 20.812    -33.137   0.79      1     24.81878 ? 67  VAL H CG2 1 
ATOM   2257 N N   . THR B 2 70  ? 23.483    -35.37    3.493     1     17.53119 ? 68  THR H N   1 
ATOM   2258 C CA  . THR B 2 70  ? 23.962    -35.726   4.789     1     22.35378 ? 68  THR H CA  1 
ATOM   2259 C C   . THR B 2 70  ? 24.634    -34.483   5.391     1     21.24875 ? 68  THR H C   1 
ATOM   2260 O O   . THR B 2 70  ? 25.489    -33.885   4.772     1     18.77202 ? 68  THR H O   1 
ATOM   2261 C CB  . THR B 2 70  ? 24.951    -36.916   4.764     1     20.45473 ? 68  THR H CB  1 
ATOM   2262 O OG1 . THR B 2 70  ? 24.293    -38.09    4.286     1     30.37095 ? 68  THR H OG1 1 
ATOM   2263 C CG2 . THR B 2 70  ? 25.506    -37.171   6.148     1     21.43147 ? 68  THR H CG2 1 
ATOM   2264 N N   . MET B 2 71  ? 24.244    -34.111   6.59      1     16.83007 ? 69  MET H N   1 
ATOM   2265 C CA  . MET B 2 71  ? 24.878    -32.986   7.275     1     17.41021 ? 69  MET H CA  1 
ATOM   2266 C C   . MET B 2 71  ? 25.589    -33.427   8.546     1     21.78713 ? 69  MET H C   1 
ATOM   2267 O O   . MET B 2 71  ? 25.228    -34.428   9.131     1     21.20533 ? 69  MET H O   1 
ATOM   2268 C CB  . MET B 2 71  ? 23.884    -31.849   7.558     1     14.18614 ? 69  MET H CB  1 
ATOM   2269 C CG  . MET B 2 71  ? 23.226    -31.22    6.352     1     16.63227 ? 69  MET H CG  1 
ATOM   2270 S SD  . MET B 2 71  ? 22.108    -29.893   6.833     1     20.60008 ? 69  MET H SD  1 
ATOM   2271 C CE  . MET B 2 71  ? 21.219    -29.659   5.309     1     16.90983 ? 69  MET H CE  1 
ATOM   2272 N N   . SER B 2 72  ? 26.596    -32.673   8.957     1     17.85194 ? 70  SER H N   1 
ATOM   2273 C CA  . SER B 2 72  ? 27.379    -33.005   10.137    1     17.17687 ? 70  SER H CA  1 
ATOM   2274 C C   . SER B 2 72  ? 27.971    -31.788   10.848    1     21.4466  ? 70  SER H C   1 
ATOM   2275 O O   . SER B 2 72  ? 28.078    -30.729   10.254    1     18.22198 ? 70  SER H O   1 
ATOM   2276 C CB  . SER B 2 72  ? 28.518    -33.945   9.773     1     15.71147 ? 70  SER H CB  1 
ATOM   2277 O OG  . SER B 2 72  ? 29.439    -33.339   8.909     1     31.36446 ? 70  SER H OG  1 
ATOM   2278 N N   . ILE B 2 73  ? 28.361    -31.968   12.105    1     23.89223 ? 71  ILE H N   1 
ATOM   2279 C CA  . ILE B 2 73  ? 28.969    -30.905   12.897    1     21.8724  ? 71  ILE H CA  1 
ATOM   2280 C C   . ILE B 2 73  ? 30.335    -31.298   13.405    1     23.31824 ? 71  ILE H C   1 
ATOM   2281 O O   . ILE B 2 73  ? 30.527    -32.397   13.878    1     21.40044 ? 71  ILE H O   1 
ATOM   2282 C CB  . ILE B 2 73  ? 28.062    -30.476   14.063    1     17.65151 ? 71  ILE H CB  1 
ATOM   2283 C CG1 . ILE B 2 73  ? 26.782    -29.85    13.512    1     15.82412 ? 71  ILE H CG1 1 
ATOM   2284 C CG2 . ILE B 2 73  ? 28.779    -29.505   14.979    1     18.62423 ? 71  ILE H CG2 1 
ATOM   2285 C CD1 . ILE B 2 73  ? 25.724    -29.582   14.551    1     20.6184  ? 71  ILE H CD1 1 
ATOM   2286 N N   . ASP B 2 74  ? 31.278    -30.396   13.273    1     20.07476 ? 72  ASP H N   1 
ATOM   2287 C CA  . ASP B 2 74  ? 32.624    -30.633   13.729    1     22.44577 ? 72  ASP H CA  1 
ATOM   2288 C C   . ASP B 2 74  ? 32.92     -29.669   14.887    1     24.27453 ? 72  ASP H C   1 
ATOM   2289 O O   . ASP B 2 74  ? 33.177    -28.498   14.673    1     19.22315 ? 72  ASP H O   1 
ATOM   2290 C CB  . ASP B 2 74  ? 33.614    -30.514   12.58     1     17.89744 ? 72  ASP H CB  1 
ATOM   2291 C CG  . ASP B 2 74  ? 35.045    -30.753   13.005    1     26.78782 ? 72  ASP H CG  1 
ATOM   2292 O OD1 . ASP B 2 74  ? 35.306    -30.924   14.201    1     29.20353 ? 72  ASP H OD1 1 
ATOM   2293 O OD2 . ASP B 2 74  ? 35.915    -30.781   12.124    1     38.48497 ? 72  ASP H OD2 1 
ATOM   2294 N N   . THR B 2 75  ? 32.856    -30.189   16.104    1     22.55187 ? 73  THR H N   1 
ATOM   2295 C CA  . THR B 2 75  ? 33.099    -29.378   17.302    1     23.4919  ? 73  THR H CA  1 
ATOM   2296 C C   . THR B 2 75  ? 34.554    -28.927   17.473    1     24.45363 ? 73  THR H C   1 
ATOM   2297 O O   . THR B 2 75  ? 34.813    -27.88    18.018    1     24.99802 ? 73  THR H O   1 
ATOM   2298 C CB  . THR B 2 75  ? 32.621    -30.137   18.563    1     28.74093 ? 73  THR H CB  1 
ATOM   2299 O OG1 . THR B 2 75  ? 33.53     -31.197   18.861    1     47.67969 ? 73  THR H OG1 1 
ATOM   2300 C CG2 . THR B 2 75  ? 31.239    -30.699   18.354    1     15.89714 ? 73  THR H CG2 1 
ATOM   2301 N N   . SER B 2 76  ? 35.488    -29.734   16.999    1     25.54364 ? 74  SER H N   1 
ATOM   2302 C CA  . SER B 2 76  ? 36.901    -29.39    17.083    1     31.99227 ? 74  SER H CA  1 
ATOM   2303 C C   . SER B 2 76  ? 37.25     -28.141   16.273    1     27.35964 ? 74  SER H C   1 
ATOM   2304 O O   . SER B 2 76  ? 38.011    -27.325   16.727    1     26.40771 ? 74  SER H O   1 
ATOM   2305 C CB  . SER B 2 76  ? 37.758    -30.588   16.661    1     28.53078 ? 74  SER H CB  1 
ATOM   2306 O OG  . SER B 2 76  ? 37.353    -31.125   15.424    1     45.85676 ? 74  SER H OG  1 
ATOM   2307 N N   . LYS B 2 77  ? 36.661    -27.993   15.101    1     24.69335 ? 75  LYS H N   1 
ATOM   2308 C CA  . LYS B 2 77  ? 36.906    -26.843   14.251    1     19.93402 ? 75  LYS H CA  1 
ATOM   2309 C C   . LYS B 2 77  ? 35.798    -25.796   14.283    1     24.58241 ? 75  LYS H C   1 
ATOM   2310 O O   . LYS B 2 77  ? 35.89     -24.809   13.59     1     25.3388  ? 75  LYS H O   1 
ATOM   2311 C CB  . LYS B 2 77  ? 37.065    -27.324   12.831    1     26.10887 ? 75  LYS H CB  1 
ATOM   2312 C CG  . LYS B 2 77  ? 38.307    -28.147   12.569    1     30.06829 ? 75  LYS H CG  1 
ATOM   2313 C CD  . LYS B 2 77  ? 38.162    -28.894   11.26     1     31.34751 ? 75  LYS H CD  1 
ATOM   2314 C CE  . LYS B 2 77  ? 39.502    -29.169   10.614    1     36.7727  ? 75  LYS H CE  1 
ATOM   2315 N NZ  . LYS B 2 77  ? 40.075    -27.911   10.067    1     54.14159 ? 75  LYS H NZ  1 
ATOM   2316 N N   . ASN B 2 78  ? 34.767    -26.014   15.087    1     23.78444 ? 76  ASN H N   1 
ATOM   2317 C CA  . ASN B 2 78  ? 33.617    -25.108   15.147    1     20.10423 ? 76  ASN H CA  1 
ATOM   2318 C C   . ASN B 2 78  ? 33.069    -24.916   13.762    1     17.89473 ? 76  ASN H C   1 
ATOM   2319 O O   . ASN B 2 78  ? 32.927    -23.812   13.293    1     18.56146 ? 76  ASN H O   1 
ATOM   2320 C CB  . ASN B 2 78  ? 33.911    -23.79    15.837    1     12.73258 ? 76  ASN H CB  1 
ATOM   2321 C CG  . ASN B 2 78  ? 32.694    -23.241   16.539    1     20.73939 ? 76  ASN H CG  1 
ATOM   2322 O OD1 . ASN B 2 78  ? 32.112    -23.908   17.382    1     16.23239 ? 76  ASN H OD1 1 
ATOM   2323 N ND2 . ASN B 2 78  ? 32.29     -22.038   16.176    1     15.95923 ? 76  ASN H ND2 1 
ATOM   2324 N N   . GLU B 2 79  ? 32.794    -26.018   13.114    1     21.89317 ? 77  GLU H N   1 
ATOM   2325 C CA  A GLU B 2 79  ? 32.247    -25.99    11.771    0.615 21.62991 ? 77  GLU H CA  1 
ATOM   2326 C CA  B GLU B 2 79  ? 32.229    -25.969   11.783    0.385 23.08765 ? 77  GLU H CA  1 
ATOM   2327 C C   . GLU B 2 79  ? 31.095    -27.009   11.534    1     23.56488 ? 77  GLU H C   1 
ATOM   2328 O O   . GLU B 2 79  ? 30.778    -27.956   12.317    1     21.69944 ? 77  GLU H O   1 
ATOM   2329 C CB  A GLU B 2 79  ? 33.329    -26.308   10.747    0.615 19.35098 ? 77  GLU H CB  1 
ATOM   2330 C CB  B GLU B 2 79  ? 33.327    -26.167   10.747    0.385 19.52386 ? 77  GLU H CB  1 
ATOM   2331 C CG  A GLU B 2 79  ? 34.564    -25.428   10.777    0.615 21.52732 ? 77  GLU H CG  1 
ATOM   2332 C CG  B GLU B 2 79  ? 33.874    -27.576   10.695    0.385 24.80656 ? 77  GLU H CG  1 
ATOM   2333 C CD  A GLU B 2 79  ? 35.664    -25.95    9.867     0.615 23.82521 ? 77  GLU H CD  1 
ATOM   2334 C CD  B GLU B 2 79  ? 35.09     -27.71    9.797     0.385 28.14087 ? 77  GLU H CD  1 
ATOM   2335 O OE1 A GLU B 2 79  ? 35.636    -27.145   9.518     0.615 24.14728 ? 77  GLU H OE1 1 
ATOM   2336 O OE1 B GLU B 2 79  ? 35.773    -26.695   9.545     0.385 23.32896 ? 77  GLU H OE1 1 
ATOM   2337 O OE2 A GLU B 2 79  ? 36.561    -25.165   9.507     0.615 26.29847 ? 77  GLU H OE2 1 
ATOM   2338 O OE2 B GLU B 2 79  ? 35.359    -28.845   9.356     0.385 22.30264 ? 77  GLU H OE2 1 
ATOM   2339 N N   . PHE B 2 80  ? 30.332    -26.719   10.517    1     21.17747 ? 78  PHE H N   1 
ATOM   2340 C CA  . PHE B 2 80  ? 29.359    -27.698   10.055    1     18.05408 ? 78  PHE H CA  1 
ATOM   2341 C C   . PHE B 2 80  ? 29.457    -27.958   8.562     1     19.89852 ? 78  PHE H C   1 
ATOM   2342 O O   . PHE B 2 80  ? 29.985    -27.151   7.832     1     18.75516 ? 78  PHE H O   1 
ATOM   2343 C CB  . PHE B 2 80  ? 27.938    -27.362   10.529    1     12.77072 ? 78  PHE H CB  1 
ATOM   2344 C CG  . PHE B 2 80  ? 27.305    -26.173   9.884     1     17.62905 ? 78  PHE H CG  1 
ATOM   2345 C CD1 . PHE B 2 80  ? 27.573    -24.897   10.333    1     15.22154 ? 78  PHE H CD1 1 
ATOM   2346 C CD2 . PHE B 2 80  ? 26.366    -26.34    8.889     1     17.67417 ? 78  PHE H CD2 1 
ATOM   2347 C CE1 . PHE B 2 80  ? 26.958    -23.81    9.761     1     15.78924 ? 78  PHE H CE1 1 
ATOM   2348 C CE2 . PHE B 2 80  ? 25.742    -25.256   8.316     1     19.34743 ? 78  PHE H CE2 1 
ATOM   2349 C CZ  . PHE B 2 80  ? 26.041    -23.986   8.751     1     11.12814 ? 78  PHE H CZ  1 
ATOM   2350 N N   . SER B 2 81  ? 28.94     -29.072   8.122     1     15.2831  ? 79  SER H N   1 
ATOM   2351 C CA  A SER B 2 81  ? 29.082    -29.461   6.728     0.629 19.27705 ? 79  SER H CA  1 
ATOM   2352 C CA  B SER B 2 81  ? 29.078    -29.436   6.723     0.371 19.44247 ? 79  SER H CA  1 
ATOM   2353 C C   . SER B 2 81  ? 27.874    -30.044   5.942     1     16.16683 ? 79  SER H C   1 
ATOM   2354 O O   . SER B 2 81  ? 26.798    -30.478   6.451     1     21.41466 ? 79  SER H O   1 
ATOM   2355 C CB  A SER B 2 81  ? 30.218    -30.504   6.63      0.629 19.21996 ? 79  SER H CB  1 
ATOM   2356 C CB  B SER B 2 81  ? 30.274    -30.403   6.594     0.371 19.33909 ? 79  SER H CB  1 
ATOM   2357 O OG  A SER B 2 81  ? 31.474    -29.952   6.96      0.629 22.93455 ? 79  SER H OG  1 
ATOM   2358 O OG  B SER B 2 81  ? 29.993    -31.633   7.222     0.371 23.75211 ? 79  SER H OG  1 
ATOM   2359 N N   . LEU B 2 82  ? 28.007    -30.02    4.636     1     16.41764 ? 80  LEU H N   1 
ATOM   2360 C CA  . LEU B 2 82  ? 26.981    -30.605   3.803     1     16.80526 ? 80  LEU H CA  1 
ATOM   2361 C C   . LEU B 2 82  ? 27.594    -31.545   2.783     1     24.31442 ? 80  LEU H C   1 
ATOM   2362 O O   . LEU B 2 82  ? 28.572    -31.202   2.141     1     19.10992 ? 80  LEU H O   1 
ATOM   2363 C CB  . LEU B 2 82  ? 26.213    -29.548   3.045     1     18.13104 ? 80  LEU H CB  1 
ATOM   2364 C CG  . LEU B 2 82  ? 25.453    -30.016   1.804     1     18.80355 ? 80  LEU H CG  1 
ATOM   2365 C CD1 . LEU B 2 82  ? 24.234    -30.833   2.183     1     23.65203 ? 80  LEU H CD1 1 
ATOM   2366 C CD2 . LEU B 2 82  ? 25.056    -28.838   0.935     1     21.35294 ? 80  LEU H CD2 1 
ATOM   2367 N N   . ARG B 2 83  ? 27.014    -32.719   2.64      1     20.76664 ? 81  ARG H N   1 
ATOM   2368 C CA  . ARG B 2 83  ? 27.444    -33.645   1.626     1     16.07346 ? 81  ARG H CA  1 
ATOM   2369 C C   . ARG B 2 83  ? 26.245    -34.014   0.764     1     20.96861 ? 81  ARG H C   1 
ATOM   2370 O O   . ARG B 2 83  ? 25.195    -34.359   1.285     1     19.76117 ? 81  ARG H O   1 
ATOM   2371 C CB  . ARG B 2 83  ? 28.086    -34.857   2.238     1     20.96499 ? 81  ARG H CB  1 
ATOM   2372 C CG  . ARG B 2 83  ? 29.366    -34.592   3.005     1     22.95513 ? 81  ARG H CG  1 
ATOM   2373 C CD  . ARG B 2 83  ? 29.889    -35.865   3.647     1     19.51592 ? 81  ARG H CD  1 
ATOM   2374 N NE  . ARG B 2 83  ? 30.127    -36.916   2.668     1     22.54657 ? 81  ARG H NE  1 
ATOM   2375 C CZ  . ARG B 2 83  ? 31.256    -37.06    1.986     1     21.09453 ? 81  ARG H CZ  1 
ATOM   2376 N NH1 . ARG B 2 83  ? 32.253    -36.215   2.166     1     22.33507 ? 81  ARG H NH1 1 
ATOM   2377 N NH2 . ARG B 2 83  ? 31.382    -38.04    1.117     1     17.47363 ? 81  ARG H NH2 1 
ATOM   2378 N N   . LEU B 2 84  ? 26.413    -33.941   -0.539    1     16.19757 ? 82  LEU H N   1 
ATOM   2379 C CA  . LEU B 2 84  ? 25.342    -34.228   -1.475    1     19.77538 ? 82  LEU H CA  1 
ATOM   2380 C C   . LEU B 2 84  ? 25.842    -35.23    -2.507    1     20.6579  ? 82  LEU H C   1 
ATOM   2381 O O   . LEU B 2 84  ? 26.717    -34.905   -3.282    1     21.32983 ? 82  LEU H O   1 
ATOM   2382 C CB  . LEU B 2 84  ? 24.818    -32.955   -2.145    1     17.92348 ? 82  LEU H CB  1 
ATOM   2383 C CG  . LEU B 2 84  ? 23.679    -33.058   -3.147    1     22.17445 ? 82  LEU H CG  1 
ATOM   2384 C CD1 . LEU B 2 84  ? 22.365    -33.264   -2.42     1     17.30174 ? 82  LEU H CD1 1 
ATOM   2385 C CD2 . LEU B 2 84  ? 23.624    -31.803   -4.003    1     19.53371 ? 82  LEU H CD2 1 
ATOM   2386 N N   . THR B 2 85  A 25.287    -36.431   -2.494    1     18.62652 ? 82  THR H N   1 
ATOM   2387 C CA  . THR B 2 85  A 25.754    -37.507   -3.355    1     24.09752 ? 82  THR H CA  1 
ATOM   2388 C C   . THR B 2 85  A 25.075    -37.455   -4.72     1     23.65218 ? 82  THR H C   1 
ATOM   2389 O O   . THR B 2 85  A 24.003    -36.869   -4.889    1     18.65993 ? 82  THR H O   1 
ATOM   2390 C CB  . THR B 2 85  A 25.492    -38.867   -2.706    1     19.16242 ? 82  THR H CB  1 
ATOM   2391 O OG1 . THR B 2 85  A 24.095    -38.992   -2.41     1     19.18167 ? 82  THR H OG1 1 
ATOM   2392 C CG2 . THR B 2 85  A 26.289    -39.007   -1.419    1     17.38713 ? 82  THR H CG2 1 
ATOM   2393 N N   . SER B 2 86  B 25.702    -38.127   -5.68     1     23.05629 ? 82  SER H N   1 
ATOM   2394 C CA  . SER B 2 86  B 25.144    -38.291   -7.026    1     22.95843 ? 82  SER H CA  1 
ATOM   2395 C C   . SER B 2 86  B 24.726    -36.979   -7.66     1     21.40277 ? 82  SER H C   1 
ATOM   2396 O O   . SER B 2 86  B 23.607    -36.847   -8.101    1     23.28171 ? 82  SER H O   1 
ATOM   2397 C CB  . SER B 2 86  B 24.018    -39.349   -6.944    1     21.91273 ? 82  SER H CB  1 
ATOM   2398 O OG  . SER B 2 86  B 24.468    -40.539   -6.342    1     29.37093 ? 82  SER H OG  1 
ATOM   2399 N N   . VAL B 2 87  C 25.671    -36.047   -7.76     1     21.55397 ? 82  VAL H N   1 
ATOM   2400 C CA  . VAL B 2 87  C 25.318    -34.709   -8.216    1     21.73218 ? 82  VAL H CA  1 
ATOM   2401 C C   . VAL B 2 87  C 25.098    -34.701   -9.724    1     24.7957  ? 82  VAL H C   1 
ATOM   2402 O O   . VAL B 2 87  C 25.686    -35.49    -10.477   1     27.08193 ? 82  VAL H O   1 
ATOM   2403 C CB  . VAL B 2 87  C 26.384    -33.676   -7.808    1     24.91003 ? 82  VAL H CB  1 
ATOM   2404 C CG1 . VAL B 2 87  C 26.507    -33.612   -6.293    1     16.20972 ? 82  VAL H CG1 1 
ATOM   2405 C CG2 . VAL B 2 87  C 27.725    -33.995   -8.456    1     24.70043 ? 82  VAL H CG2 1 
ATOM   2406 N N   . THR B 2 88  ? 24.228    -33.808   -10.165   1     24.31143 ? 83  THR H N   1 
ATOM   2407 C CA  . THR B 2 88  ? 23.989    -33.577   -11.579   1     23.62768 ? 83  THR H CA  1 
ATOM   2408 C C   . THR B 2 88  ? 24.06     -32.07    -11.805   1     23.64027 ? 83  THR H C   1 
ATOM   2409 O O   . THR B 2 88  ? 24.203    -31.314   -10.878   1     22.11848 ? 83  THR H O   1 
ATOM   2410 C CB  . THR B 2 88  ? 22.619    -34.062   -12.082   1     19.65431 ? 83  THR H CB  1 
ATOM   2411 O OG1 . THR B 2 88  ? 21.583    -33.225   -11.571   1     30.85763 ? 83  THR H OG1 1 
ATOM   2412 C CG2 . THR B 2 88  ? 22.376    -35.503   -11.659   1     25.45576 ? 83  THR H CG2 1 
ATOM   2413 N N   . ALA B 2 89  ? 23.925    -31.647   -13.045   1     23.81172 ? 84  ALA H N   1 
ATOM   2414 C CA  . ALA B 2 89  ? 23.954    -30.227   -13.358   1     30.03335 ? 84  ALA H CA  1 
ATOM   2415 C C   . ALA B 2 89  ? 22.887    -29.462   -12.608   1     26.12722 ? 84  ALA H C   1 
ATOM   2416 O O   . ALA B 2 89  ? 23.031    -28.292   -12.371   1     22.81058 ? 84  ALA H O   1 
ATOM   2417 C CB  . ALA B 2 89  ? 23.806    -30.025   -14.845   1     30.88841 ? 84  ALA H CB  1 
ATOM   2418 N N   . ALA B 2 90  ? 21.826    -30.141   -12.232   1     20.32064 ? 85  ALA H N   1 
ATOM   2419 C CA  . ALA B 2 90  ? 20.794    -29.542   -11.443   1     22.82506 ? 85  ALA H CA  1 
ATOM   2420 C C   . ALA B 2 90  ? 21.288    -29.093   -10.064   1     21.73152 ? 85  ALA H C   1 
ATOM   2421 O O   . ALA B 2 90  ? 20.65     -28.299   -9.424    1     21.1724  ? 85  ALA H O   1 
ATOM   2422 C CB  . ALA B 2 90  ? 19.699    -30.55    -11.28    1     23.32361 ? 85  ALA H CB  1 
ATOM   2423 N N   . ASP B 2 91  ? 22.417    -29.616   -9.627    1     21.85781 ? 86  ASP H N   1 
ATOM   2424 C CA  . ASP B 2 91  ? 22.997    -29.254   -8.353    1     18.82937 ? 86  ASP H CA  1 
ATOM   2425 C C   . ASP B 2 91  ? 23.957    -28.062   -8.474    1     16.26829 ? 86  ASP H C   1 
ATOM   2426 O O   . ASP B 2 91  ? 24.5      -27.61    -7.495    1     19.40539 ? 86  ASP H O   1 
ATOM   2427 C CB  . ASP B 2 91  ? 23.653    -30.468   -7.766    1     14.8604  ? 86  ASP H CB  1 
ATOM   2428 C CG  . ASP B 2 91  ? 22.676    -31.593   -7.535    1     18.45685 ? 86  ASP H CG  1 
ATOM   2429 O OD1 . ASP B 2 91  ? 21.636    -31.352   -6.906    1     22.05088 ? 86  ASP H OD1 1 
ATOM   2430 O OD2 . ASP B 2 91  ? 22.953    -32.712   -7.982    1     20.95823 ? 86  ASP H OD2 1 
ATOM   2431 N N   . THR B 2 92  ? 24.164    -27.591   -9.687    1     18.12716 ? 87  THR H N   1 
ATOM   2432 C CA  . THR B 2 92  ? 24.972    -26.4     -9.877    1     20.94358 ? 87  THR H CA  1 
ATOM   2433 C C   . THR B 2 92  ? 24.23     -25.21    -9.256    1     20.96169 ? 87  THR H C   1 
ATOM   2434 O O   . THR B 2 92  ? 23.143    -24.881   -9.666    1     13.97542 ? 87  THR H O   1 
ATOM   2435 C CB  . THR B 2 92  ? 25.377    -26.141   -11.355   1     22.10325 ? 87  THR H CB  1 
ATOM   2436 O OG1 . THR B 2 92  ? 26.317    -27.131   -11.779   1     20.20093 ? 87  THR H OG1 1 
ATOM   2437 C CG2 . THR B 2 92  ? 25.981    -24.752   -11.508   1     16.35188 ? 87  THR H CG2 1 
ATOM   2438 N N   . ALA B 2 93  ? 24.832    -24.639   -8.223    1     15.24054 ? 88  ALA H N   1 
ATOM   2439 C CA  . ALA B 2 93  ? 24.216    -23.537   -7.508    1     15.219   ? 88  ALA H CA  1 
ATOM   2440 C C   . ALA B 2 93  ? 25.096    -22.865   -6.501    1     19.05744 ? 88  ALA H C   1 
ATOM   2441 O O   . ALA B 2 93  ? 26.18     -23.333   -6.181    1     11.93881 ? 88  ALA H O   1 
ATOM   2442 C CB  . ALA B 2 93  ? 22.959    -23.99    -6.802    1     11.73019 ? 88  ALA H CB  1 
ATOM   2443 N N   . VAL B 2 94  ? 24.602    -21.731   -6.044    1     16.27903 ? 89  VAL H N   1 
ATOM   2444 C CA  . VAL B 2 94  ? 25.278    -21.052   -5.002    1     14.88804 ? 89  VAL H CA  1 
ATOM   2445 C C   . VAL B 2 94  ? 24.751    -21.658   -3.714    1     15.48889 ? 89  VAL H C   1 
ATOM   2446 O O   . VAL B 2 94  ? 23.556    -21.692   -3.488    1     12.89968 ? 89  VAL H O   1 
ATOM   2447 C CB  . VAL B 2 94  ? 25.066    -19.532   -5.039    1     19.73697 ? 89  VAL H CB  1 
ATOM   2448 C CG1 . VAL B 2 94  ? 25.547    -18.901   -3.744    1     16.01515 ? 89  VAL H CG1 1 
ATOM   2449 C CG2 . VAL B 2 94  ? 25.747    -18.911   -6.246    1     13.89595 ? 89  VAL H CG2 1 
ATOM   2450 N N   . TYR B 2 95  ? 25.657    -22.121   -2.892    1     13.42005 ? 90  TYR H N   1 
ATOM   2451 C CA  . TYR B 2 95  ? 25.306    -22.707   -1.623    1     13.26777 ? 90  TYR H CA  1 
ATOM   2452 C C   . TYR B 2 95  ? 25.559    -21.784   -0.419    1     14.76969 ? 90  TYR H C   1 
ATOM   2453 O O   . TYR B 2 95  ? 26.65     -21.291   -0.232    1     16.1274  ? 90  TYR H O   1 
ATOM   2454 C CB  . TYR B 2 95  ? 26.017    -24.039   -1.477    1     11.53025 ? 90  TYR H CB  1 
ATOM   2455 C CG  . TYR B 2 95  ? 25.474    -25.116   -2.393    1     17.23181 ? 90  TYR H CG  1 
ATOM   2456 C CD1 . TYR B 2 95  ? 25.783    -25.129   -3.742    1     12.33229 ? 90  TYR H CD1 1 
ATOM   2457 C CD2 . TYR B 2 95  ? 24.649    -26.112   -1.907    1     15.10469 ? 90  TYR H CD2 1 
ATOM   2458 C CE1 . TYR B 2 95  ? 25.286    -26.106   -4.579    1     11.97025 ? 90  TYR H CE1 1 
ATOM   2459 C CE2 . TYR B 2 95  ? 24.153    -27.095   -2.733    1     14.83268 ? 90  TYR H CE2 1 
ATOM   2460 C CZ  . TYR B 2 95  ? 24.473    -27.09    -4.069    1     18.45583 ? 90  TYR H CZ  1 
ATOM   2461 O OH  . TYR B 2 95  ? 23.973    -28.067   -4.883    1     18.23666 ? 90  TYR H OH  1 
ATOM   2462 N N   . PHE B 2 96  ? 24.535    -21.583   0.378     1     14.88034 ? 91  PHE H N   1 
ATOM   2463 C CA  . PHE B 2 96  ? 24.625    -20.734   1.551     1     14.91188 ? 91  PHE H CA  1 
ATOM   2464 C C   . PHE B 2 96  ? 24.501    -21.498   2.856     1     16.52709 ? 91  PHE H C   1 
ATOM   2465 O O   . PHE B 2 96  ? 23.63     -22.327   3.016     1     13.04662 ? 91  PHE H O   1 
ATOM   2466 C CB  . PHE B 2 96  ? 23.517    -19.668   1.579     1     14.77202 ? 91  PHE H CB  1 
ATOM   2467 C CG  . PHE B 2 96  ? 23.398    -18.836   0.349     1     18.20639 ? 91  PHE H CG  1 
ATOM   2468 C CD1 . PHE B 2 96  ? 22.613    -19.252   -0.707    1     14.91144 ? 91  PHE H CD1 1 
ATOM   2469 C CD2 . PHE B 2 96  ? 24.015    -17.603   0.276     1     14.33162 ? 91  PHE H CD2 1 
ATOM   2470 C CE1 . PHE B 2 96  ? 22.479    -18.471   -1.831    1     17.08065 ? 91  PHE H CE1 1 
ATOM   2471 C CE2 . PHE B 2 96  ? 23.884    -16.818   -0.846    1     15.88508 ? 91  PHE H CE2 1 
ATOM   2472 C CZ  . PHE B 2 96  ? 23.117    -17.253   -1.9      1     19.41653 ? 91  PHE H CZ  1 
ATOM   2473 N N   . CYS B 2 97  ? 25.392    -21.211   3.785     1     16.64423 ? 92  CYS H N   1 
ATOM   2474 C CA  . CYS B 2 97  ? 25.254    -21.774   5.114     1     16.95056 ? 92  CYS H CA  1 
ATOM   2475 C C   . CYS B 2 97  ? 24.635    -20.707   5.997     1     17.45362 ? 92  CYS H C   1 
ATOM   2476 O O   . CYS B 2 97  ? 24.78     -19.531   5.737     1     17.1002  ? 92  CYS H O   1 
ATOM   2477 C CB  . CYS B 2 97  ? 26.579    -22.276   5.706     1     20.18989 ? 92  CYS H CB  1 
ATOM   2478 S SG  . CYS B 2 97  ? 27.891    -21.085   5.955     1     20.57841 ? 92  CYS H SG  1 
ATOM   2479 N N   . ALA B 2 98  ? 23.946    -21.134   7.035     1     14.86546 ? 93  ALA H N   1 
ATOM   2480 C CA  . ALA B 2 98  ? 23.289    -20.185   7.894     1     14.7374  ? 93  ALA H CA  1 
ATOM   2481 C C   . ALA B 2 98  ? 22.959    -20.662   9.305     1     16.84547 ? 93  ALA H C   1 
ATOM   2482 O O   . ALA B 2 98  ? 22.888    -21.842   9.567     1     15.46067 ? 93  ALA H O   1 
ATOM   2483 C CB  . ALA B 2 98  ? 22.022    -19.671   7.213     1     12.66708 ? 93  ALA H CB  1 
ATOM   2484 N N   . ARG B 2 99  ? 22.743    -19.713   10.194    1     14.75663 ? 94  ARG H N   1 
ATOM   2485 C CA  . ARG B 2 99  ? 22.346    -20.028   11.542    1     13.21536 ? 94  ARG H CA  1 
ATOM   2486 C C   . ARG B 2 99  ? 20.978    -19.492   11.906    1     12.47273 ? 94  ARG H C   1 
ATOM   2487 O O   . ARG B 2 99  ? 20.58     -18.461   11.423    1     14.93145 ? 94  ARG H O   1 
ATOM   2488 C CB  . ARG B 2 99  ? 23.363    -19.5     12.562    1     11.05737 ? 94  ARG H CB  1 
ATOM   2489 C CG  . ARG B 2 99  ? 23.124    -19.929   14.001    1     13.13388 ? 94  ARG H CG  1 
ATOM   2490 C CD  . ARG B 2 99  ? 23.929    -19.088   14.977    1     12.81334 ? 94  ARG H CD  1 
ATOM   2491 N NE  . ARG B 2 99  ? 23.217    -17.881   15.375    1     17.03741 ? 94  ARG H NE  1 
ATOM   2492 C CZ  . ARG B 2 99  ? 23.719    -16.92    16.14     1     21.60121 ? 94  ARG H CZ  1 
ATOM   2493 N NH1 . ARG B 2 99  ? 24.957    -16.999   16.594    1     17.72907 ? 94  ARG H NH1 1 
ATOM   2494 N NH2 . ARG B 2 99  ? 22.977    -15.87    16.447    1     17.91529 ? 94  ARG H NH2 1 
ATOM   2495 N N   . GLY B 2 100 ? 20.303    -20.208   12.766    1     13.60045 ? 95  GLY H N   1 
ATOM   2496 C CA  . GLY B 2 100 ? 19.042    -19.798   13.284    1     12.0309  ? 95  GLY H CA  1 
ATOM   2497 C C   . GLY B 2 100 ? 18.97     -20.063   14.783    1     15.9651  ? 95  GLY H C   1 
ATOM   2498 O O   . GLY B 2 100 ? 19.739    -20.83    15.326    1     16.06488 ? 95  GLY H O   1 
ATOM   2499 N N   . THR B 2 101 ? 18.041    -19.419   15.436    1     17.69116 ? 96  THR H N   1 
ATOM   2500 C CA  . THR B 2 101 ? 17.84     -19.57    16.87     1     18.72601 ? 96  THR H CA  1 
ATOM   2501 C C   . THR B 2 101 ? 16.452    -20.149   17.094    1     14.22439 ? 96  THR H C   1 
ATOM   2502 O O   . THR B 2 101 ? 15.461    -19.583   16.622    1     12.41471 ? 96  THR H O   1 
ATOM   2503 C CB  . THR B 2 101 ? 17.992    -18.228   17.591    1     16.10541 ? 96  THR H CB  1 
ATOM   2504 O OG1 . THR B 2 101 ? 19.258    -17.647   17.255    1     15.15784 ? 96  THR H OG1 1 
ATOM   2505 C CG2 . THR B 2 101 ? 17.918    -18.419   19.095    1     18.77664 ? 96  THR H CG2 1 
ATOM   2506 N N   . GLU B 2 102 ? 16.385    -21.278   17.798    1     19.31672 ? 97  GLU H N   1 
ATOM   2507 C CA  . GLU B 2 102 ? 15.108    -21.951   18        1     16.70738 ? 97  GLU H CA  1 
ATOM   2508 C C   . GLU B 2 102 ? 14.133    -21.031   18.722    1     18.22802 ? 97  GLU H C   1 
ATOM   2509 O O   . GLU B 2 102 ? 14.461    -20.445   19.759    1     16.41642 ? 97  GLU H O   1 
ATOM   2510 C CB  . GLU B 2 102 ? 15.306    -23.249   18.782    1     15.58318 ? 97  GLU H CB  1 
ATOM   2511 C CG  . GLU B 2 102 ? 14.053    -24.118   18.859    1     16.2293  ? 97  GLU H CG  1 
ATOM   2512 C CD  . GLU B 2 102 ? 13.783    -24.901   17.582    1     19.8417  ? 97  GLU H CD  1 
ATOM   2513 O OE1 . GLU B 2 102 ? 13.948    -24.342   16.476    1     17.99747 ? 97  GLU H OE1 1 
ATOM   2514 O OE2 . GLU B 2 102 ? 13.397    -26.084   17.686    1     23.62432 ? 97  GLU H OE2 1 
ATOM   2515 N N   . ASP B 2 103 ? 12.925    -20.908   18.164    1     16.72167 ? 98  ASP H N   1 
ATOM   2516 C CA  . ASP B 2 103 ? 11.974    -19.877   18.557    1     15.3865  ? 98  ASP H CA  1 
ATOM   2517 C C   . ASP B 2 103 ? 10.566    -20.393   18.245    1     14.38115 ? 98  ASP H C   1 
ATOM   2518 O O   . ASP B 2 103 ? 9.856     -19.885   17.379    1     15.82746 ? 98  ASP H O   1 
ATOM   2519 C CB  . ASP B 2 103 ? 12.281    -18.565   17.832    1     16.33177 ? 98  ASP H CB  1 
ATOM   2520 C CG  . ASP B 2 103 ? 11.59     -17.376   18.45     1     19.54676 ? 98  ASP H CG  1 
ATOM   2521 O OD1 . ASP B 2 103 ? 11.291    -17.422   19.662    1     17.37304 ? 98  ASP H OD1 1 
ATOM   2522 O OD2 . ASP B 2 103 ? 11.356    -16.39    17.719    1     17.33332 ? 98  ASP H OD2 1 
ATOM   2523 N N   . LEU B 2 104 ? 10.149    -21.421   18.992    1     16.23753 ? 99  LEU H N   1 
ATOM   2524 C CA  . LEU B 2 104 ? 8.983     -22.217   18.617    1     16.56738 ? 99  LEU H CA  1 
ATOM   2525 C C   . LEU B 2 104 ? 7.681     -21.425   18.617    1     20.06765 ? 99  LEU H C   1 
ATOM   2526 O O   . LEU B 2 104 ? 6.726     -21.834   17.948    1     38.63165 ? 99  LEU H O   1 
ATOM   2527 C CB  . LEU B 2 104 ? 8.852     -23.422   19.549    1     12.46877 ? 99  LEU H CB  1 
ATOM   2528 C CG  . LEU B 2 104 ? 9.893     -24.52    19.329    1     20.03302 ? 99  LEU H CG  1 
ATOM   2529 C CD1 . LEU B 2 104 ? 9.59      -25.731   20.192    1     23.5436  ? 99  LEU H CD1 1 
ATOM   2530 C CD2 . LEU B 2 104 ? 9.949     -24.907   17.858    1     20.98674 ? 99  LEU H CD2 1 
ATOM   2531 N N   . GLY B 2 105 ? 7.606     -20.314   19.349    1     17.92738 ? 100 GLY H N   1 
ATOM   2532 C CA  . GLY B 2 105 ? 6.387     -19.524   19.32     1     29.90822 ? 100 GLY H CA  1 
ATOM   2533 C C   . GLY B 2 105 ? 6.149     -18.801   18.009    1     29.488   ? 100 GLY H C   1 
ATOM   2534 O O   . GLY B 2 105 ? 5.015     -18.398   17.731    1     31.66925 ? 100 GLY H O   1 
ATOM   2535 N N   . TYR B 2 106 A 7.192     -18.64    17.192    1     21.41636 ? 100 TYR H N   1 
ATOM   2536 C CA  . TYR B 2 106 A 7.129     -17.806   16.002    1     21.43303 ? 100 TYR H CA  1 
ATOM   2537 C C   . TYR B 2 106 A 7.745     -18.466   14.782    1     19.02217 ? 100 TYR H C   1 
ATOM   2538 O O   . TYR B 2 106 A 7.82      -17.832   13.724    1     19.35108 ? 100 TYR H O   1 
ATOM   2539 C CB  . TYR B 2 106 A 7.822     -16.461   16.271    1     17.65252 ? 100 TYR H CB  1 
ATOM   2540 C CG  . TYR B 2 106 A 7.31      -15.824   17.536    1     21.60273 ? 100 TYR H CG  1 
ATOM   2541 C CD1 . TYR B 2 106 A 6.191     -15.007   17.511    1     25.1063  ? 100 TYR H CD1 1 
ATOM   2542 C CD2 . TYR B 2 106 A 7.917     -16.072   18.762    1     23.13852 ? 100 TYR H CD2 1 
ATOM   2543 C CE1 . TYR B 2 106 A 5.701     -14.44    18.662    1     23.5727  ? 100 TYR H CE1 1 
ATOM   2544 C CE2 . TYR B 2 106 A 7.431     -15.509   19.923    1     22.71887 ? 100 TYR H CE2 1 
ATOM   2545 C CZ  . TYR B 2 106 A 6.321     -14.692   19.863    1     19.65594 ? 100 TYR H CZ  1 
ATOM   2546 O OH  . TYR B 2 106 A 5.816     -14.119   21.003    1     22.9294  ? 100 TYR H OH  1 
ATOM   2547 N N   . CYS B 2 107 B 8.173     -19.718   14.894    1     19.61133 ? 100 CYS H N   1 
ATOM   2548 C CA  . CYS B 2 107 B 8.837     -20.415   13.807    1     22.97134 ? 100 CYS H CA  1 
ATOM   2549 C C   . CYS B 2 107 B 8.74      -21.905   14.079    1     21.83819 ? 100 CYS H C   1 
ATOM   2550 O O   . CYS B 2 107 B 8.814     -22.331   15.235    1     22.77624 ? 100 CYS H O   1 
ATOM   2551 C CB  . CYS B 2 107 B 10.305    -19.987   13.697    1     23.47122 ? 100 CYS H CB  1 
ATOM   2552 S SG  . CYS B 2 107 B 11.181    -20.643   12.271    1     21.13968 ? 100 CYS H SG  1 
ATOM   2553 N N   . SER B 2 108 C 8.558     -22.69    13.02     1     26.94894 ? 100 SER H N   1 
ATOM   2554 C CA  . SER B 2 108 C 8.734     -24.125   13.164    1     25.25309 ? 100 SER H CA  1 
ATOM   2555 C C   . SER B 2 108 C 10.177    -24.415   13.556    1     20.39189 ? 100 SER H C   1 
ATOM   2556 O O   . SER B 2 108 C 11.073    -23.584   13.39     1     21.25361 ? 100 SER H O   1 
ATOM   2557 C CB  . SER B 2 108 C 8.381     -24.856   11.869    1     25.87098 ? 100 SER H CB  1 
ATOM   2558 O OG  . SER B 2 108 C 6.978     -24.908   11.683    1     26.20056 ? 100 SER H OG  1 
ATOM   2559 N N   . SER B 2 109 D 10.396    -25.609   14.095    1     22.50241 ? 100 SER H N   1 
ATOM   2560 C CA  . SER B 2 109 D 11.73     -25.979   14.54     1     19.00934 ? 100 SER H CA  1 
ATOM   2561 C C   . SER B 2 109 D 12.719    -25.916   13.382    1     21.64711 ? 100 SER H C   1 
ATOM   2562 O O   . SER B 2 109 D 12.483    -26.489   12.314    1     18.27676 ? 100 SER H O   1 
ATOM   2563 C CB  . SER B 2 109 D 11.708    -27.377   15.148    1     23.18672 ? 100 SER H CB  1 
ATOM   2564 O OG  . SER B 2 109 D 13.023    -27.846   15.385    1     29.18152 ? 100 SER H OG  1 
ATOM   2565 N N   . GLY B 2 110 E 13.812    -25.187   13.591    1     20.15415 ? 100 GLY H N   1 
ATOM   2566 C CA  . GLY B 2 110 E 14.895    -25.131   12.623    1     17.11731 ? 100 GLY H CA  1 
ATOM   2567 C C   . GLY B 2 110 E 14.531    -24.54    11.279    1     16.08527 ? 100 GLY H C   1 
ATOM   2568 O O   . GLY B 2 110 E 15.168    -24.877   10.275    1     18.64378 ? 100 GLY H O   1 
ATOM   2569 N N   . SER B 2 111 F 13.547    -23.641   11.229    1     15.63517 ? 100 SER H N   1 
ATOM   2570 C CA  . SER B 2 111 F 12.983    -23.202   9.957     1     18.43012 ? 100 SER H CA  1 
ATOM   2571 C C   . SER B 2 111 F 13.142    -21.709   9.678     1     18.36151 ? 100 SER H C   1 
ATOM   2572 O O   . SER B 2 111 F 12.527    -21.208   8.728     1     18.63498 ? 100 SER H O   1 
ATOM   2573 C CB  . SER B 2 111 F 11.499    -23.578   9.89      1     17.71245 ? 100 SER H CB  1 
ATOM   2574 O OG  . SER B 2 111 F 11.324    -24.981   9.978     1     21.85503 ? 100 SER H OG  1 
ATOM   2575 N N   . CYS B 2 112 G 13.938    -20.981   10.46     1     17.2077  ? 100 CYS H N   1 
ATOM   2576 C CA  . CYS B 2 112 G 14.119    -19.54    10.263    1     18.98488 ? 100 CYS H CA  1 
ATOM   2577 C C   . CYS B 2 112 G 15.589    -19.161   10.367    1     19.18716 ? 100 CYS H C   1 
ATOM   2578 O O   . CYS B 2 112 G 16.032    -18.58    11.365    1     19.47602 ? 100 CYS H O   1 
ATOM   2579 C CB  . CYS B 2 112 G 13.29     -18.739   11.27     1     16.6269  ? 100 CYS H CB  1 
ATOM   2580 S SG  . CYS B 2 112 G 11.514    -18.995   11.132    1     20.39929 ? 100 CYS H SG  1 
ATOM   2581 N N   . PRO B 2 113 H 16.378    -19.455   9.333     1     18.03167 ? 100 PRO H N   1 
ATOM   2582 C CA  . PRO B 2 113 H 17.783    -19.015   9.328     1     17.31924 ? 100 PRO H CA  1 
ATOM   2583 C C   . PRO B 2 113 H 17.865    -17.498   9.226     1     15.92622 ? 100 PRO H C   1 
ATOM   2584 O O   . PRO B 2 113 H 17.397    -16.906   8.253     1     10.86365 ? 100 PRO H O   1 
ATOM   2585 C CB  . PRO B 2 113 H 18.365    -19.701   8.087     1     15.579   ? 100 PRO H CB  1 
ATOM   2586 C CG  . PRO B 2 113 H 17.183    -19.927   7.195     1     18.28784 ? 100 PRO H CG  1 
ATOM   2587 C CD  . PRO B 2 113 H 16.008    -20.166   8.098     1     14.94179 ? 100 PRO H CD  1 
ATOM   2588 N N   . ASN B 2 114 ? 18.461    -16.866   10.241    1     17.40414 ? 101 ASN H N   1 
ATOM   2589 C CA  . ASN B 2 114 ? 18.502    -15.411   10.31     1     19.9164  ? 101 ASN H CA  1 
ATOM   2590 C C   . ASN B 2 114 ? 19.905    -14.824   10.23     1     17.61252 ? 101 ASN H C   1 
ATOM   2591 O O   . ASN B 2 114 ? 20.045    -13.596   10.282    1     23.1425  ? 101 ASN H O   1 
ATOM   2592 C CB  . ASN B 2 114 ? 17.804    -14.919   11.588    1     14.40722 ? 101 ASN H CB  1 
ATOM   2593 C CG  . ASN B 2 114 ? 18.615    -15.177   12.839    1     16.58072 ? 101 ASN H CG  1 
ATOM   2594 O OD1 . ASN B 2 114 ? 19.35     -16.16    12.926    1     18.82252 ? 101 ASN H OD1 1 
ATOM   2595 N ND2 . ASN B 2 114 ? 18.483    -14.292   13.82     1     18.06245 ? 101 ASN H ND2 1 
ATOM   2596 N N   . HIS B 2 115 ? 20.943    -15.651   10.103    1     16.63365 ? 102 HIS H N   1 
ATOM   2597 C CA  . HIS B 2 115 ? 22.301    -15.171   9.851     1     16.71301 ? 102 HIS H CA  1 
ATOM   2598 C C   . HIS B 2 115 ? 22.919    -16.07    8.789     1     18.06573 ? 102 HIS H C   1 
ATOM   2599 O O   . HIS B 2 115 ? 23.246    -17.226   9.071     1     18.79186 ? 102 HIS H O   1 
ATOM   2600 C CB  . HIS B 2 115 ? 23.15     -15.165   11.124    1     15.17119 ? 102 HIS H CB  1 
ATOM   2601 C CG  . HIS B 2 115 ? 22.67     -14.205   12.169    1     31.57255 ? 102 HIS H CG  1 
ATOM   2602 N ND1 . HIS B 2 115 ? 23.002    -12.867   12.158    1     32.1971  ? 102 HIS H ND1 1 
ATOM   2603 C CD2 . HIS B 2 115 ? 21.893    -14.39    13.263    1     30.24817 ? 102 HIS H CD2 1 
ATOM   2604 C CE1 . HIS B 2 115 ? 22.443    -12.267   13.194    1     26.174   ? 102 HIS H CE1 1 
ATOM   2605 N NE2 . HIS B 2 115 ? 21.766    -13.169   13.881    1     34.69547 ? 102 HIS H NE2 1 
ATOM   2606 N N   . TRP B 2 116 ? 23.081    -15.542   7.579     1     11.90292 ? 103 TRP H N   1 
ATOM   2607 C CA  . TRP B 2 116 ? 23.535    -16.313   6.432     1     13.77209 ? 103 TRP H CA  1 
ATOM   2608 C C   . TRP B 2 116 ? 24.972    -15.96    6.074     1     15.91257 ? 103 TRP H C   1 
ATOM   2609 O O   . TRP B 2 116 ? 25.435    -14.841   6.311     1     13.76253 ? 103 TRP H O   1 
ATOM   2610 C CB  . TRP B 2 116 ? 22.659    -16.058   5.199     1     10.85248 ? 103 TRP H CB  1 
ATOM   2611 C CG  . TRP B 2 116 ? 21.219    -16.453   5.311     1     14.15037 ? 103 TRP H CG  1 
ATOM   2612 C CD1 . TRP B 2 116 ? 20.406    -16.328   6.402     1     15.41119 ? 103 TRP H CD1 1 
ATOM   2613 C CD2 . TRP B 2 116 ? 20.409    -17.011   4.269     1     17.03631 ? 103 TRP H CD2 1 
ATOM   2614 N NE1 . TRP B 2 116 ? 19.143    -16.787   6.104     1     13.86643 ? 103 TRP H NE1 1 
ATOM   2615 C CE2 . TRP B 2 116 ? 19.12     -17.211   4.801     1     14.00746 ? 103 TRP H CE2 1 
ATOM   2616 C CE3 . TRP B 2 116 ? 20.653    -17.368   2.938     1     15.52174 ? 103 TRP H CE3 1 
ATOM   2617 C CZ2 . TRP B 2 116 ? 18.077    -17.751   4.049     1     14.96869 ? 103 TRP H CZ2 1 
ATOM   2618 C CZ3 . TRP B 2 116 ? 19.615    -17.903   2.193     1     14.04475 ? 103 TRP H CZ3 1 
ATOM   2619 C CH2 . TRP B 2 116 ? 18.344    -18.09    2.751     1     15.04427 ? 103 TRP H CH2 1 
ATOM   2620 N N   . GLY B 2 117 ? 25.671    -16.926   5.485     1     12.48291 ? 104 GLY H N   1 
ATOM   2621 C CA  . GLY B 2 117 ? 26.907    -16.631   4.798     1     16.92681 ? 104 GLY H CA  1 
ATOM   2622 C C   . GLY B 2 117 ? 26.64     -16.028   3.43      1     21.50344 ? 104 GLY H C   1 
ATOM   2623 O O   . GLY B 2 117 ? 25.503    -15.945   2.966     1     19.31253 ? 104 GLY H O   1 
ATOM   2624 N N   . GLN B 2 118 ? 27.716    -15.601   2.773     1     18.93688 ? 105 GLN H N   1 
ATOM   2625 C CA  . GLN B 2 118 ? 27.581    -14.966   1.469     1     28.38855 ? 105 GLN H CA  1 
ATOM   2626 C C   . GLN B 2 118 ? 27.44     -15.965   0.327     1     24.74471 ? 105 GLN H C   1 
ATOM   2627 O O   . GLN B 2 118 ? 27.103    -15.559   -0.79     1     19.97855 ? 105 GLN H O   1 
ATOM   2628 C CB  . GLN B 2 118 ? 28.77     -14.036   1.215     1     22.80847 ? 105 GLN H CB  1 
ATOM   2629 C CG  . GLN B 2 118 ? 28.667    -12.715   1.966     1     30.14369 ? 105 GLN H CG  1 
ATOM   2630 C CD  . GLN B 2 118 ? 29.675    -11.685   1.497     1     42.66628 ? 105 GLN H CD  1 
ATOM   2631 O OE1 . GLN B 2 118 ? 30.616    -12.004   0.771     1     36.13563 ? 105 GLN H OE1 1 
ATOM   2632 N NE2 . GLN B 2 118 ? 29.48     -10.437   1.91      1     38.81777 ? 105 GLN H NE2 1 
ATOM   2633 N N   . GLY B 2 119 ? 27.669    -17.229   0.589     1     17.93622 ? 106 GLY H N   1 
ATOM   2634 C CA  . GLY B 2 119 ? 27.511    -18.231   -0.422    1     16.70558 ? 106 GLY H CA  1 
ATOM   2635 C C   . GLY B 2 119 ? 28.713    -18.65    -1.217    1     21.99699 ? 106 GLY H C   1 
ATOM   2636 O O   . GLY B 2 119 ? 29.614    -17.858   -1.418    1     19.21635 ? 106 GLY H O   1 
ATOM   2637 N N   . THR B 2 120 ? 28.727    -19.907   -1.634    1     20.10624 ? 107 THR H N   1 
ATOM   2638 C CA  . THR B 2 120 ? 29.796    -20.43    -2.459    1     22.10262 ? 107 THR H CA  1 
ATOM   2639 C C   . THR B 2 120 ? 29.224    -21.124   -3.721    1     22.24533 ? 107 THR H C   1 
ATOM   2640 O O   . THR B 2 120 ? 28.285    -21.887   -3.648    1     17.93573 ? 107 THR H O   1 
ATOM   2641 C CB  . THR B 2 120 ? 30.757    -21.377   -1.703    1     15.14268 ? 107 THR H CB  1 
ATOM   2642 O OG1 . THR B 2 120 ? 31.85     -21.729   -2.557    1     18.73962 ? 107 THR H OG1 1 
ATOM   2643 C CG2 . THR B 2 120 ? 30.034    -22.624   -1.242    1     15.88281 ? 107 THR H CG2 1 
ATOM   2644 N N   . LEU B 2 121 ? 29.815    -20.839   -4.862    1     20.52546 ? 108 LEU H N   1 
ATOM   2645 C CA  . LEU B 2 121 ? 29.325    -21.394   -6.111    1     16.00685 ? 108 LEU H CA  1 
ATOM   2646 C C   . LEU B 2 121 ? 29.892    -22.759   -6.407    1     18.82306 ? 108 LEU H C   1 
ATOM   2647 O O   . LEU B 2 121 ? 31.096    -22.93    -6.458    1     21.65694 ? 108 LEU H O   1 
ATOM   2648 C CB  . LEU B 2 121 ? 29.629    -20.496   -7.291    1     15.11835 ? 108 LEU H CB  1 
ATOM   2649 C CG  . LEU B 2 121 ? 29.222    -21.089   -8.644    1     17.36102 ? 108 LEU H CG  1 
ATOM   2650 C CD1 . LEU B 2 121 ? 27.712    -21.213   -8.758    1     16.45189 ? 108 LEU H CD1 1 
ATOM   2651 C CD2 . LEU B 2 121 ? 29.794    -20.302   -9.807    1     17.06623 ? 108 LEU H CD2 1 
ATOM   2652 N N   . VAL B 2 122 ? 29.02     -23.712   -6.593    1     16.56787 ? 109 VAL H N   1 
ATOM   2653 C CA  . VAL B 2 122 ? 29.437    -25.04    -6.966    1     16.63063 ? 109 VAL H CA  1 
ATOM   2654 C C   . VAL B 2 122 ? 29        -25.347   -8.394    1     17.06916 ? 109 VAL H C   1 
ATOM   2655 O O   . VAL B 2 122 ? 27.846    -25.197   -8.714    1     16.62601 ? 109 VAL H O   1 
ATOM   2656 C CB  . VAL B 2 122 ? 28.915    -26.107   -5.974    1     19.76016 ? 109 VAL H CB  1 
ATOM   2657 C CG1 . VAL B 2 122 ? 29.245    -27.505   -6.459    1     25.16015 ? 109 VAL H CG1 1 
ATOM   2658 C CG2 . VAL B 2 122 ? 29.456    -25.868   -4.578    1     18.46602 ? 109 VAL H CG2 1 
ATOM   2659 N N   . THR B 2 123 ? 29.944    -25.767   -9.224    1     16.20261 ? 110 THR H N   1 
ATOM   2660 C CA  . THR B 2 123 ? 29.672    -26.1     -10.615   1     19.38524 ? 110 THR H CA  1 
ATOM   2661 C C   . THR B 2 123 ? 29.899    -27.589   -10.828   1     22.9085  ? 110 THR H C   1 
ATOM   2662 O O   . THR B 2 123 ? 30.981    -28.106   -10.529   1     16.63734 ? 110 THR H O   1 
ATOM   2663 C CB  . THR B 2 123 ? 30.562    -25.292   -11.564   1     20.72885 ? 110 THR H CB  1 
ATOM   2664 O OG1 . THR B 2 123 ? 30.483    -23.899   -11.232   1     19.8499  ? 110 THR H OG1 1 
ATOM   2665 C CG2 . THR B 2 123 ? 30.117    -25.488   -13.004   1     19.95897 ? 110 THR H CG2 1 
ATOM   2666 N N   . VAL B 2 124 ? 28.872    -28.266   -11.318   1     19.30739 ? 111 VAL H N   1 
ATOM   2667 C CA  . VAL B 2 124 ? 28.978    -29.679   -11.623   1     21.619   ? 111 VAL H CA  1 
ATOM   2668 C C   . VAL B 2 124 ? 29.415    -29.869   -13.074   1     21.31648 ? 111 VAL H C   1 
ATOM   2669 O O   . VAL B 2 124 ? 28.653    -29.599   -13.97    1     28.17502 ? 111 VAL H O   1 
ATOM   2670 C CB  . VAL B 2 124 ? 27.679    -30.446   -11.301   1     19.26223 ? 111 VAL H CB  1 
ATOM   2671 C CG1 . VAL B 2 124 ? 27.795    -31.906   -11.698   1     17.67169 ? 111 VAL H CG1 1 
ATOM   2672 C CG2 . VAL B 2 124 ? 27.304    -30.286   -9.842    1     20.46684 ? 111 VAL H CG2 1 
ATOM   2673 N N   . SER B 2 125 ? 30.649    -30.288   -13.271   1     24.44907 ? 112 SER H N   1 
ATOM   2674 C CA  . SER B 2 125 ? 31.197    -30.52    -14.598   1     28.59235 ? 112 SER H CA  1 
ATOM   2675 C C   . SER B 2 125 ? 32.216    -31.625   -14.618   1     25.44442 ? 112 SER H C   1 
ATOM   2676 O O   . SER B 2 125 ? 32.824    -31.918   -13.622   1     33.08769 ? 112 SER H O   1 
ATOM   2677 C CB  . SER B 2 125 ? 31.891    -29.268   -15.168   1     23.70678 ? 112 SER H CB  1 
ATOM   2678 O OG  . SER B 2 125 ? 32.543    -29.504   -16.388   1     33.18366 ? 112 SER H OG  1 
ATOM   2679 N N   . SER B 2 126 ? 32.413    -32.21    -15.783   1     30.64384 ? 113 SER H N   1 
ATOM   2680 C CA  . SER B 2 126 ? 33.433    -33.218   -15.96    1     36.29726 ? 113 SER H CA  1 
ATOM   2681 C C   . SER B 2 126 ? 34.68     -32.543   -16.506   1     38.4403  ? 113 SER H C   1 
ATOM   2682 O O   . SER B 2 126 ? 35.673    -33.195   -16.75    1     40.12576 ? 113 SER H O   1 
ATOM   2683 C CB  . SER B 2 126 ? 32.926    -34.277   -16.92    1     27.45688 ? 113 SER H CB  1 
ATOM   2684 O OG  . SER B 2 126 ? 32.478    -33.692   -18.122   1     47.85024 ? 113 SER H OG  1 
ATOM   2685 N N   . ALA B 2 127 ? 34.624    -31.223   -16.686   1     38.33162 ? 114 ALA H N   1 
ATOM   2686 C CA  . ALA B 2 127 ? 35.77     -30.458   -17.198   1     37.82987 ? 114 ALA H CA  1 
ATOM   2687 C C   . ALA B 2 127 ? 36.777    -30.061   -16.156   1     37.02286 ? 114 ALA H C   1 
ATOM   2688 O O   . ALA B 2 127 ? 36.5      -30.099   -14.982   1     35.05272 ? 114 ALA H O   1 
ATOM   2689 C CB  . ALA B 2 127 ? 35.308    -29.22    -17.913   1     34.64328 ? 114 ALA H CB  1 
ATOM   2690 N N   . SER B 2 128 ? 37.94     -29.656   -16.61    1     34.09609 ? 115 SER H N   1 
ATOM   2691 C CA  . SER B 2 128 ? 39.005    -29.281   -15.714   1     36.02728 ? 115 SER H CA  1 
ATOM   2692 C C   . SER B 2 128 ? 39.042    -27.817   -15.367   1     27.48918 ? 115 SER H C   1 
ATOM   2693 O O   . SER B 2 128 ? 38.517    -26.997   -16.082   1     31.9348  ? 115 SER H O   1 
ATOM   2694 C CB  . SER B 2 128 ? 40.338    -29.629   -16.374   1     37.037   ? 115 SER H CB  1 
ATOM   2695 O OG  . SER B 2 128 ? 40.351    -30.951   -16.867   1     57.34499 ? 115 SER H OG  1 
ATOM   2696 N N   . THR B 2 129 ? 39.709    -27.494   -14.285   1     26.44649 ? 116 THR H N   1 
ATOM   2697 C CA  . THR B 2 129 ? 39.874    -26.118   -13.914   1     35.31372 ? 116 THR H CA  1 
ATOM   2698 C C   . THR B 2 129 ? 40.921    -25.433   -14.767   1     40.92792 ? 116 THR H C   1 
ATOM   2699 O O   . THR B 2 129 ? 41.921    -26.038   -15.116   1     36.86195 ? 116 THR H O   1 
ATOM   2700 C CB  . THR B 2 129 ? 40.313    -25.963   -12.452   1     35.97201 ? 116 THR H CB  1 
ATOM   2701 O OG1 . THR B 2 129 ? 41.663    -26.41    -12.304   1     50.61095 ? 116 THR H OG1 1 
ATOM   2702 C CG2 . THR B 2 129 ? 39.41     -26.768   -11.531   1     38.48206 ? 116 THR H CG2 1 
ATOM   2703 N N   . LYS B 2 130 ? 40.679    -24.186   -15.119   1     33.85423 ? 117 LYS H N   1 
ATOM   2704 C CA  . LYS B 2 130 ? 41.647    -23.399   -15.84    1     30.54352 ? 117 LYS H CA  1 
ATOM   2705 C C   . LYS B 2 130 ? 41.713    -22.036   -15.197   1     33.94381 ? 117 LYS H C   1 
ATOM   2706 O O   . LYS B 2 130 ? 40.717    -21.36    -15.028   1     28.36032 ? 117 LYS H O   1 
ATOM   2707 C CB  . LYS B 2 130 ? 41.306    -23.272   -17.318   1     31.97072 ? 117 LYS H CB  1 
ATOM   2708 C CG  . LYS B 2 130 ? 42.312    -22.448   -18.085   1     36.76992 ? 117 LYS H CG  1 
ATOM   2709 C CD  . LYS B 2 130 ? 42.029    -22.441   -19.571   1     39.71219 ? 117 LYS H CD  1 
ATOM   2710 C CE  . LYS B 2 130 ? 43.16     -21.744   -20.299   1     38.07541 ? 117 LYS H CE  1 
ATOM   2711 N NZ  . LYS B 2 130 ? 43.503    -20.464   -19.624   1     48.04748 ? 117 LYS H NZ  1 
ATOM   2712 N N   . GLY B 2 131 ? 42.906    -21.644   -14.828   1     28.54007 ? 118 GLY H N   1 
ATOM   2713 C CA  . GLY B 2 131 ? 43.09     -20.348   -14.246   1     27.43709 ? 118 GLY H CA  1 
ATOM   2714 C C   . GLY B 2 131 ? 43.061    -19.26    -15.287   1     29.88584 ? 118 GLY H C   1 
ATOM   2715 O O   . GLY B 2 131 ? 43.197    -19.515   -16.471   1     29.98683 ? 118 GLY H O   1 
ATOM   2716 N N   . PRO B 2 132 ? 42.854    -18.045   -14.839   1     25.01325 ? 119 PRO H N   1 
ATOM   2717 C CA  . PRO B 2 132 ? 42.715    -16.983   -15.822   1     25.90439 ? 119 PRO H CA  1 
ATOM   2718 C C   . PRO B 2 132 ? 44.004    -16.337   -16.302   1     33.4839  ? 119 PRO H C   1 
ATOM   2719 O O   . PRO B 2 132 ? 44.996    -16.355   -15.595   1     25.50192 ? 119 PRO H O   1 
ATOM   2720 C CB  . PRO B 2 132 ? 41.91     -15.94    -15.056   1     28.20324 ? 119 PRO H CB  1 
ATOM   2721 C CG  . PRO B 2 132 ? 42.301    -16.132   -13.638   1     31.92981 ? 119 PRO H CG  1 
ATOM   2722 C CD  . PRO B 2 132 ? 42.548    -17.598   -13.472   1     24.17897 ? 119 PRO H CD  1 
ATOM   2723 N N   . SER B 2 133 ? 43.961    -15.758   -17.489   1     34.26243 ? 120 SER H N   1 
ATOM   2724 C CA  . SER B 2 133 ? 45.082    -15.013   -18.006   1     24.05331 ? 120 SER H CA  1 
ATOM   2725 C C   . SER B 2 133 ? 44.679    -13.543   -17.918   1     36.33544 ? 120 SER H C   1 
ATOM   2726 O O   . SER B 2 133 ? 43.668    -13.153   -18.477   1     40.60665 ? 120 SER H O   1 
ATOM   2727 C CB  . SER B 2 133 ? 45.375    -15.456   -19.416   1     23.86291 ? 120 SER H CB  1 
ATOM   2728 O OG  . SER B 2 133 ? 45.598    -16.845   -19.493   1     42.78007 ? 120 SER H OG  1 
ATOM   2729 N N   . VAL B 2 134 ? 45.433    -12.732   -17.192   1     30.07257 ? 121 VAL H N   1 
ATOM   2730 C CA  . VAL B 2 134 ? 45.049    -11.348   -16.989   1     30.3873  ? 121 VAL H CA  1 
ATOM   2731 C C   . VAL B 2 134 ? 45.828    -10.367   -17.836   1     37.94334 ? 121 VAL H C   1 
ATOM   2732 O O   . VAL B 2 134 ? 47.042    -10.396   -17.857   1     43.08566 ? 121 VAL H O   1 
ATOM   2733 C CB  . VAL B 2 134 ? 45.179    -10.957   -15.518   1     28.91723 ? 121 VAL H CB  1 
ATOM   2734 C CG1 . VAL B 2 134 ? 44.749    -9.519    -15.295   1     27.95602 ? 121 VAL H CG1 1 
ATOM   2735 C CG2 . VAL B 2 134 ? 44.383    -11.905   -14.641   1     31.52567 ? 121 VAL H CG2 1 
ATOM   2736 N N   . PHE B 2 135 ? 45.12     -9.494    -18.523   1     37.9806  ? 122 PHE H N   1 
ATOM   2737 C CA  . PHE B 2 135 ? 45.735    -8.536    -19.389   1     32.91593 ? 122 PHE H CA  1 
ATOM   2738 C C   . PHE B 2 135 ? 45.339    -7.12     -19.029   1     36.06773 ? 122 PHE H C   1 
ATOM   2739 O O   . PHE B 2 135 ? 44.268    -6.881    -18.502   1     29.70273 ? 122 PHE H O   1 
ATOM   2740 C CB  . PHE B 2 135 ? 45.325    -8.814    -20.825   1     34.66948 ? 122 PHE H CB  1 
ATOM   2741 C CG  . PHE B 2 135 ? 45.747    -10.15    -21.337   1     37.16219 ? 122 PHE H CG  1 
ATOM   2742 C CD1 . PHE B 2 135 ? 47.078    -10.432   -21.546   1     37.03397 ? 122 PHE H CD1 1 
ATOM   2743 C CD2 . PHE B 2 135 ? 44.806    -11.113   -21.636   1     30.56788 ? 122 PHE H CD2 1 
ATOM   2744 C CE1 . PHE B 2 135 ? 47.468    -11.66    -22.029   1     39.13006 ? 122 PHE H CE1 1 
ATOM   2745 C CE2 . PHE B 2 135 ? 45.189    -12.343   -22.124   1     40.19196 ? 122 PHE H CE2 1 
ATOM   2746 C CZ  . PHE B 2 135 ? 46.524    -12.617   -22.322   1     37.78458 ? 122 PHE H CZ  1 
ATOM   2747 N N   . PRO B 2 136 ? 46.203    -6.161    -19.356   1     35.04884 ? 123 PRO H N   1 
ATOM   2748 C CA  . PRO B 2 136 ? 45.905    -4.794    -18.963   1     30.67434 ? 123 PRO H CA  1 
ATOM   2749 C C   . PRO B 2 136 ? 45.042    -3.978    -19.913   1     28.78877 ? 123 PRO H C   1 
ATOM   2750 O O   . PRO B 2 136 ? 45.172    -4.11     -21.106   1     31.43424 ? 123 PRO H O   1 
ATOM   2751 C CB  . PRO B 2 136 ? 47.304    -4.185    -18.868   1     37.20518 ? 123 PRO H CB  1 
ATOM   2752 C CG  . PRO B 2 136 ? 48.07     -4.871    -19.934   1     35.00183 ? 123 PRO H CG  1 
ATOM   2753 C CD  . PRO B 2 136 ? 47.485    -6.244    -20.082   1     37.46298 ? 123 PRO H CD  1 
ATOM   2754 N N   . LEU B 2 137 ? 44.145    -3.178    -19.361   1     34.83181 ? 124 LEU H N   1 
ATOM   2755 C CA  . LEU B 2 137 ? 43.322    -2.277    -20.145   1     33.03006 ? 124 LEU H CA  1 
ATOM   2756 C C   . LEU B 2 137 ? 43.876    -0.917    -19.751   1     32.7799  ? 124 LEU H C   1 
ATOM   2757 O O   . LEU B 2 137 ? 43.378    -0.259    -18.854   1     31.58234 ? 124 LEU H O   1 
ATOM   2758 C CB  . LEU B 2 137 ? 41.85     -2.472    -19.833   1     28.43072 ? 124 LEU H CB  1 
ATOM   2759 C CG  . LEU B 2 137 ? 41.171    -3.783    -20.204   1     31.10662 ? 124 LEU H CG  1 
ATOM   2760 C CD1 . LEU B 2 137 ? 39.849    -3.913    -19.478   1     23.24084 ? 124 LEU H CD1 1 
ATOM   2761 C CD2 . LEU B 2 137 ? 40.97     -3.879    -21.703   1     31.2796  ? 124 LEU H CD2 1 
ATOM   2762 N N   . ALA B 2 138 ? 44.916    -0.502    -20.446   1     37.8352  ? 125 ALA H N   1 
ATOM   2763 C CA  . ALA B 2 138 ? 45.623    0.723     -20.08    1     39.40488 ? 125 ALA H CA  1 
ATOM   2764 C C   . ALA B 2 138 ? 45.002    2.057     -20.397   1     34.68546 ? 125 ALA H C   1 
ATOM   2765 O O   . ALA B 2 138 ? 44.418    2.247     -21.436   1     32.9529  ? 125 ALA H O   1 
ATOM   2766 C CB  . ALA B 2 138 ? 47.019    0.673     -20.671   1     44.73527 ? 125 ALA H CB  1 
ATOM   2767 N N   . PRO B 2 139 ? 45.171    2.986     -19.464   1     40.93946 ? 126 PRO H N   1 
ATOM   2768 C CA  . PRO B 2 139 ? 44.659    4.329     -19.666   1     40.43961 ? 126 PRO H CA  1 
ATOM   2769 C C   . PRO B 2 139 ? 45.399    5         -20.801   1     53.33582 ? 126 PRO H C   1 
ATOM   2770 O O   . PRO B 2 139 ? 46.616    4.893     -20.882   1     55.68742 ? 126 PRO H O   1 
ATOM   2771 C CB  . PRO B 2 139 ? 44.968    5.021     -18.342   1     42.14868 ? 126 PRO H CB  1 
ATOM   2772 C CG  . PRO B 2 139 ? 46.091    4.252     -17.748   1     45.9171  ? 126 PRO H CG  1 
ATOM   2773 C CD  . PRO B 2 139 ? 45.904    2.842     -18.198   1     46.21443 ? 126 PRO H CD  1 
ATOM   2774 N N   . SER B 2 140 ? 44.671    5.661     -21.676   1     60.932   ? 127 SER H N   1 
ATOM   2775 C CA  . SER B 2 140 ? 45.263    6.366     -22.791   1     57.91571 ? 127 SER H CA  1 
ATOM   2776 C C   . SER B 2 140 ? 44.36     7.519     -23.146   1     72.28307 ? 127 SER H C   1 
ATOM   2777 O O   . SER B 2 140 ? 43.439    7.848     -22.399   1     68.77726 ? 127 SER H O   1 
ATOM   2778 C CB  . SER B 2 140 ? 45.347    5.461     -23.983   1     61.73835 ? 127 SER H CB  1 
ATOM   2779 O OG  . SER B 2 140 ? 45.983    4.241     -23.656   1     74.33895 ? 127 SER H OG  1 
ATOM   2780 N N   . SER B 2 141 ? 44.585    8.122     -24.305   1     78.64215 ? 128 SER H N   1 
ATOM   2781 C CA  . SER B 2 141 ? 43.772    9.239     -24.753   1     73.90402 ? 128 SER H CA  1 
ATOM   2782 C C   . SER B 2 141 ? 42.38     8.774     -25.095   1     74.35786 ? 128 SER H C   1 
ATOM   2783 O O   . SER B 2 141 ? 41.426    9.527     -24.96    1     72.88892 ? 128 SER H O   1 
ATOM   2784 C CB  . SER B 2 141 ? 44.431    9.892     -25.964   1     67.14959 ? 128 SER H CB  1 
ATOM   2785 O OG  . SER B 2 141 ? 45.793    10.154    -25.699   1     81.73241 ? 128 SER H OG  1 
ATOM   2786 N N   . LYS B 2 142 ? 42.25     7.533     -25.537   1     75.99266 ? 129 LYS H N   1 
ATOM   2787 C CA  . LYS B 2 142 ? 40.949    6.966     -25.84    1     70.69533 ? 129 LYS H CA  1 
ATOM   2788 C C   . LYS B 2 142 ? 40.21     6.646     -24.554   1     61.89513 ? 129 LYS H C   1 
ATOM   2789 O O   . LYS B 2 142 ? 39.135    6.067     -24.587   1     45.52884 ? 129 LYS H O   1 
ATOM   2790 C CB  . LYS B 2 142 ? 41.13     5.72      -26.689   1     69.72231 ? 129 LYS H CB  1 
ATOM   2791 C CG  . LYS B 2 142 ? 41.884    5.956     -27.986   1     66.74956 ? 129 LYS H CG  1 
ATOM   2792 C CD  . LYS B 2 142 ? 41.212    7.026     -28.827   1     63.75746 ? 129 LYS H CD  1 
ATOM   2793 C CE  . LYS B 2 142 ? 42.136    7.51      -29.928   1     62.79182 ? 129 LYS H CE  1 
ATOM   2794 N NZ  . LYS B 2 142 ? 41.5      8.547     -30.785   1     69.07297 ? 129 LYS H NZ  1 
ATOM   2795 N N   . SER B 2 143 ? 40.792    7.054     -23.429   1     70.18207 ? 130 SER H N   1 
ATOM   2796 C CA  . SER B 2 143 ? 40.192    6.813     -22.132   1     60.75377 ? 130 SER H CA  1 
ATOM   2797 C C   . SER B 2 143 ? 40.284    8.014     -21.227   1     70.11439 ? 130 SER H C   1 
ATOM   2798 O O   . SER B 2 143 ? 40.655    7.869     -20.071   1     67.06911 ? 130 SER H O   1 
ATOM   2799 C CB  . SER B 2 143 ? 40.885    5.668     -21.415   1     50.76162 ? 130 SER H CB  1 
ATOM   2800 O OG  . SER B 2 143 ? 40.294    5.449     -20.162   1     57.38802 ? 130 SER H OG  1 
ATOM   2801 N N   . THR B 2 144 ? 39.947    9.179     -21.658   1     71.71963 ? 131 THR H N   1 
ATOM   2802 C CA  . THR B 2 144 ? 39.915    10.324    -20.761   1     69.20417 ? 131 THR H CA  1 
ATOM   2803 C C   . THR B 2 144 ? 38.641    11.091    -21.012   1     75.46957 ? 131 THR H C   1 
ATOM   2804 O O   . THR B 2 144 ? 38.001    10.921    -22.044   1     78.2474  ? 131 THR H O   1 
ATOM   2805 C CB  . THR B 2 144 ? 41.125    11.233    -20.959   1     70.2948  ? 131 THR H CB  1 
ATOM   2806 O OG1 . THR B 2 144 ? 42.285    10.43     -21.203   1     71.08979 ? 131 THR H OG1 1 
ATOM   2807 C CG2 . THR B 2 144 ? 41.367    12.094    -19.724   1     55.95087 ? 131 THR H CG2 1 
ATOM   2808 N N   . SER B 2 145 ? 38.262    11.937    -20.118   1     70.90446 ? 132 SER H N   1 
ATOM   2809 C CA  . SER B 2 145 ? 37.093    12.735    -20.299   1     63.50682 ? 132 SER H CA  1 
ATOM   2810 C C   . SER B 2 145 ? 37.425    14.137    -19.893   1     74.47329 ? 132 SER H C   1 
ATOM   2811 O O   . SER B 2 145 ? 36.805    15.082    -20.37    1     83.10729 ? 132 SER H O   1 
ATOM   2812 C CB  . SER B 2 145 ? 36.001    12.214    -19.43    1     69.14459 ? 132 SER H CB  1 
ATOM   2813 O OG  . SER B 2 145 ? 35.729    10.861    -19.721   1     79.6138  ? 132 SER H OG  1 
ATOM   2814 N N   . GLY B 2 146 ? 38.404    14.286    -19.019   1     65.35317 ? 133 GLY H N   1 
ATOM   2815 C CA  . GLY B 2 146 ? 38.765    15.599    -18.525   1     70.7008  ? 133 GLY H CA  1 
ATOM   2816 C C   . GLY B 2 146 ? 38.594    15.639    -17.034   1     63.37936 ? 133 GLY H C   1 
ATOM   2817 O O   . GLY B 2 146 ? 37.538    15.994    -16.516   1     59.17948 ? 133 GLY H O   1 
ATOM   2818 N N   . GLY B 2 147 ? 39.635    15.301    -16.32    1     58.26857 ? 134 GLY H N   1 
ATOM   2819 C CA  . GLY B 2 147 ? 39.492    15.202    -14.891   1     55.69852 ? 134 GLY H CA  1 
ATOM   2820 C C   . GLY B 2 147 ? 39.189    13.754    -14.563   1     57.85613 ? 134 GLY H C   1 
ATOM   2821 O O   . GLY B 2 147 ? 39.208    13.374    -13.401   1     52.03799 ? 134 GLY H O   1 
ATOM   2822 N N   . THR B 2 148 ? 38.914    12.943    -15.588   1     56.47693 ? 135 THR H N   1 
ATOM   2823 C CA  . THR B 2 148 ? 38.607    11.518    -15.383   1     53.22439 ? 135 THR H CA  1 
ATOM   2824 C C   . THR B 2 148 ? 39.225    10.58     -16.405   1     54.01902 ? 135 THR H C   1 
ATOM   2825 O O   . THR B 2 148 ? 39.132    10.829    -17.596   1     51.99757 ? 135 THR H O   1 
ATOM   2826 C CB  . THR B 2 148 ? 37.097    11.236    -15.38    1     52.8383  ? 135 THR H CB  1 
ATOM   2827 O OG1 . THR B 2 148 ? 36.513    11.706    -16.594   1     66.78612 ? 135 THR H OG1 1 
ATOM   2828 C CG2 . THR B 2 148 ? 36.423    11.919    -14.201   1     47.28455 ? 135 THR H CG2 1 
ATOM   2829 N N   . ALA B 2 149 ? 39.852    9.506     -15.944   1     36.29224 ? 136 ALA H N   1 
ATOM   2830 C CA  . ALA B 2 149 ? 40.39     8.505     -16.85    1     40.34853 ? 136 ALA H CA  1 
ATOM   2831 C C   . ALA B 2 149 ? 39.914    7.098     -16.504   1     34.94128 ? 136 ALA H C   1 
ATOM   2832 O O   . ALA B 2 149 ? 39.585    6.824     -15.369   1     34.01567 ? 136 ALA H O   1 
ATOM   2833 C CB  . ALA B 2 149 ? 41.898    8.531     -16.853   1     42.43334 ? 136 ALA H CB  1 
ATOM   2834 N N   . ALA B 2 150 ? 39.911    6.213     -17.484   1     25.51073 ? 137 ALA H N   1 
ATOM   2835 C CA  . ALA B 2 150 ? 39.482    4.851     -17.254   1     28.63173 ? 137 ALA H CA  1 
ATOM   2836 C C   . ALA B 2 150 ? 40.555    3.834     -17.543   1     25.22017 ? 137 ALA H C   1 
ATOM   2837 O O   . ALA B 2 150 ? 41.236    3.906     -18.536   1     31.93447 ? 137 ALA H O   1 
ATOM   2838 C CB  . ALA B 2 150 ? 38.236    4.523     -18.056   1     23.6746  ? 137 ALA H CB  1 
ATOM   2839 N N   . LEU B 2 151 ? 40.679    2.88      -16.656   1     25.59548 ? 138 LEU H N   1 
ATOM   2840 C CA  . LEU B 2 151 ? 41.634    1.829     -16.826   1     30.57386 ? 138 LEU H CA  1 
ATOM   2841 C C   . LEU B 2 151 ? 41.028    0.538     -16.347   1     28.51063 ? 138 LEU H C   1 
ATOM   2842 O O   . LEU B 2 151 ? 39.967    0.538     -15.751   1     30.06394 ? 138 LEU H O   1 
ATOM   2843 C CB  . LEU B 2 151 ? 42.909    2.127     -16.027   1     30.75253 ? 138 LEU H CB  1 
ATOM   2844 C CG  . LEU B 2 151 ? 42.802    2.337     -14.525   1     33.81988 ? 138 LEU H CG  1 
ATOM   2845 C CD1 . LEU B 2 151 ? 43.141    1.046     -13.809   1     38.09381 ? 138 LEU H CD1 1 
ATOM   2846 C CD2 . LEU B 2 151 ? 43.774    3.424     -14.106   1     40.53675 ? 138 LEU H CD2 1 
ATOM   2847 N N   . GLY B 2 152 ? 41.714    -0.561    -16.595   1     26.9648  ? 139 GLY H N   1 
ATOM   2848 C CA  . GLY B 2 152 ? 41.249    -1.838    -16.126   1     30.96863 ? 139 GLY H CA  1 
ATOM   2849 C C   . GLY B 2 152 ? 42.017    -3.097    -16.43    1     34.0245  ? 139 GLY H C   1 
ATOM   2850 O O   . GLY B 2 152 ? 43.124    -3.03     -16.947   1     31.03872 ? 139 GLY H O   1 
ATOM   2851 N N   . CYS B 2 153 ? 41.437    -4.238    -16.088   1     27.90673 ? 140 CYS H N   1 
ATOM   2852 C CA  . CYS B 2 153 ? 42.047    -5.533    -16.355   1     26.5145  ? 140 CYS H CA  1 
ATOM   2853 C C   . CYS B 2 153 ? 41.11     -6.52     -17.079   1     25.49142 ? 140 CYS H C   1 
ATOM   2854 O O   . CYS B 2 153 ? 39.957    -6.64     -16.72    1     25.59545 ? 140 CYS H O   1 
ATOM   2855 C CB  . CYS B 2 153 ? 42.538    -6.168    -15.05    1     21.52522 ? 140 CYS H CB  1 
ATOM   2856 S SG  . CYS B 2 153 ? 44.042    -5.476    -14.344   1     38.62722 ? 140 CYS H SG  1 
ATOM   2857 N N   . LEU B 2 154 ? 41.609    -7.183    -18.093   1     21.8264  ? 141 LEU H N   1 
ATOM   2858 C CA  . LEU B 2 154 ? 40.835    -8.169    -18.801   1     28.66297 ? 141 LEU H CA  1 
ATOM   2859 C C   . LEU B 2 154 ? 41.182    -9.545    -18.257   1     26.37328 ? 141 LEU H C   1 
ATOM   2860 O O   . LEU B 2 154 ? 42.309    -9.97     -18.365   1     25.82279 ? 141 LEU H O   1 
ATOM   2861 C CB  . LEU B 2 154 ? 41.091    -8.108    -20.302   1     22.06973 ? 141 LEU H CB  1 
ATOM   2862 C CG  . LEU B 2 154 ? 40.482    -9.18     -21.192   1     27.34382 ? 141 LEU H CG  1 
ATOM   2863 C CD1 . LEU B 2 154 ? 38.974    -9.231    -21.041   1     28.58206 ? 141 LEU H CD1 1 
ATOM   2864 C CD2 . LEU B 2 154 ? 40.87     -8.95     -22.638   1     25.57922 ? 141 LEU H CD2 1 
ATOM   2865 N N   . VAL B 2 155 ? 40.213    -10.216   -17.66    1     25.38568 ? 142 VAL H N   1 
ATOM   2866 C CA  . VAL B 2 155 ? 40.423    -11.549   -17.079   1     24.28858 ? 142 VAL H CA  1 
ATOM   2867 C C   . VAL B 2 155 ? 39.828    -12.581   -18.015   1     26.55271 ? 142 VAL H C   1 
ATOM   2868 O O   . VAL B 2 155 ? 38.628    -12.77    -18.061   1     25.67892 ? 142 VAL H O   1 
ATOM   2869 C CB  . VAL B 2 155 ? 39.844    -11.637   -15.668   1     24.05099 ? 142 VAL H CB  1 
ATOM   2870 C CG1 . VAL B 2 155 ? 40.227    -12.941   -15.003   1     24.98381 ? 142 VAL H CG1 1 
ATOM   2871 C CG2 . VAL B 2 155 ? 40.274    -10.445   -14.84    1     23.5146  ? 142 VAL H CG2 1 
ATOM   2872 N N   . LYS B 2 156 ? 40.672    -13.269   -18.746   1     21.49062 ? 143 LYS H N   1 
ATOM   2873 C CA  . LYS B 2 156 ? 40.168    -14.147   -19.769   1     26.49575 ? 143 LYS H CA  1 
ATOM   2874 C C   . LYS B 2 156 ? 40.447    -15.625   -19.689   1     25.95317 ? 143 LYS H C   1 
ATOM   2875 O O   . LYS B 2 156 ? 41.438    -16.041   -19.129   1     28.70555 ? 143 LYS H O   1 
ATOM   2876 C CB  . LYS B 2 156 ? 40.715    -13.668   -21.122   1     27.75607 ? 143 LYS H CB  1 
ATOM   2877 C CG  . LYS B 2 156 ? 40.121    -14.314   -22.355   1     31.31981 ? 143 LYS H CG  1 
ATOM   2878 C CD  . LYS B 2 156 ? 40.419    -13.475   -23.583   1     31.84937 ? 143 LYS H CD  1 
ATOM   2879 C CE  . LYS B 2 156 ? 40.344    -14.291   -24.858   1     38.19308 ? 143 LYS H CE  1 
ATOM   2880 N NZ  . LYS B 2 156 ? 38.989    -14.849   -25.094   1     45.33569 ? 143 LYS H NZ  1 
ATOM   2881 N N   . ASP B 2 157 ? 39.555    -16.405   -20.259   1     27.92881 ? 144 ASP H N   1 
ATOM   2882 C CA  . ASP B 2 157 ? 39.739    -17.848   -20.364   1     33.58475 ? 144 ASP H CA  1 
ATOM   2883 C C   . ASP B 2 157 ? 39.897    -18.658   -19.062   1     32.98663 ? 144 ASP H C   1 
ATOM   2884 O O   . ASP B 2 157 ? 40.917    -19.277   -18.833   1     38.87043 ? 144 ASP H O   1 
ATOM   2885 C CB  . ASP B 2 157 ? 40.895    -18.093   -21.345   1     36.32109 ? 144 ASP H CB  1 
ATOM   2886 C CG  . ASP B 2 157 ? 40.579    -17.613   -22.731   1     35.40457 ? 144 ASP H CG  1 
ATOM   2887 O OD1 . ASP B 2 157 ? 39.397    -17.66    -23.113   1     36.08746 ? 144 ASP H OD1 1 
ATOM   2888 O OD2 . ASP B 2 157 ? 41.508    -17.189   -23.435   1     39.46471 ? 144 ASP H OD2 1 
ATOM   2889 N N   . TYR B 2 158 ? 38.871    -18.656   -18.238   1     26.21757 ? 145 TYR H N   1 
ATOM   2890 C CA  . TYR B 2 158 ? 38.919    -19.389   -17.001   1     25.88318 ? 145 TYR H CA  1 
ATOM   2891 C C   . TYR B 2 158 ? 37.707    -20.299   -16.801   1     27.17844 ? 145 TYR H C   1 
ATOM   2892 O O   . TYR B 2 158 ? 36.695    -20.123   -17.462   1     24.70885 ? 145 TYR H O   1 
ATOM   2893 C CB  . TYR B 2 158 ? 39.095    -18.429   -15.823   1     24.04156 ? 145 TYR H CB  1 
ATOM   2894 C CG  . TYR B 2 158 ? 37.951    -17.493   -15.535   1     25.5439  ? 145 TYR H CG  1 
ATOM   2895 C CD1 . TYR B 2 158 ? 36.915    -17.869   -14.7     1     22.00765 ? 145 TYR H CD1 1 
ATOM   2896 C CD2 . TYR B 2 158 ? 37.93     -16.213   -16.066   1     26.84899 ? 145 TYR H CD2 1 
ATOM   2897 C CE1 . TYR B 2 158 ? 35.876    -17.005   -14.423   1     21.92334 ? 145 TYR H CE1 1 
ATOM   2898 C CE2 . TYR B 2 158 ? 36.898    -15.346   -15.799   1     18.8459  ? 145 TYR H CE2 1 
ATOM   2899 C CZ  . TYR B 2 158 ? 35.876    -15.747   -14.973   1     22.51161 ? 145 TYR H CZ  1 
ATOM   2900 O OH  . TYR B 2 158 ? 34.854    -14.891   -14.702   1     20.48044 ? 145 TYR H OH  1 
ATOM   2901 N N   . PHE B 2 159 ? 37.834    -21.274   -15.916   1     24.08156 ? 146 PHE H N   1 
ATOM   2902 C CA  . PHE B 2 159 ? 36.755    -22.204   -15.596   1     22.93731 ? 146 PHE H CA  1 
ATOM   2903 C C   . PHE B 2 159 ? 37.128    -22.92    -14.293   1     23.54691 ? 146 PHE H C   1 
ATOM   2904 O O   . PHE B 2 159 ? 38.263    -23.252   -14.075   1     24.12994 ? 146 PHE H O   1 
ATOM   2905 C CB  . PHE B 2 159 ? 36.508    -23.201   -16.724   1     23.71709 ? 146 PHE H CB  1 
ATOM   2906 C CG  . PHE B 2 159 ? 35.315    -24.076   -16.535   1     26.33151 ? 146 PHE H CG  1 
ATOM   2907 C CD1 . PHE B 2 159 ? 34.074    -23.678   -16.986   1     26.37517 ? 146 PHE H CD1 1 
ATOM   2908 C CD2 . PHE B 2 159 ? 35.44     -25.314   -15.942   1     25.04065 ? 146 PHE H CD2 1 
ATOM   2909 C CE1 . PHE B 2 159 ? 32.975    -24.488   -16.827   1     23.15973 ? 146 PHE H CE1 1 
ATOM   2910 C CE2 . PHE B 2 159 ? 34.345    -26.131   -15.784   1     26.28633 ? 146 PHE H CE2 1 
ATOM   2911 C CZ  . PHE B 2 159 ? 33.11     -25.719   -16.225   1     21.66565 ? 146 PHE H CZ  1 
ATOM   2912 N N   . PRO B 2 160 ? 36.144    -23.157   -13.438   1     25.1603  ? 147 PRO H N   1 
ATOM   2913 C CA  . PRO B 2 160 ? 34.829    -22.537   -13.586   1     22.55151 ? 147 PRO H CA  1 
ATOM   2914 C C   . PRO B 2 160 ? 34.718    -21.168   -12.958   1     22.02117 ? 147 PRO H C   1 
ATOM   2915 O O   . PRO B 2 160 ? 35.699    -20.592   -12.574   1     21.20689 ? 147 PRO H O   1 
ATOM   2916 C CB  . PRO B 2 160 ? 33.961    -23.452   -12.754   1     19.30461 ? 147 PRO H CB  1 
ATOM   2917 C CG  . PRO B 2 160 ? 34.847    -23.836   -11.624   1     22.80043 ? 147 PRO H CG  1 
ATOM   2918 C CD  . PRO B 2 160 ? 36.226    -23.961   -12.209   1     23.98734 ? 147 PRO H CD  1 
ATOM   2919 N N   . GLU B 2 161 ? 33.513    -20.641   -12.901   1     22.30464 ? 148 GLU H N   1 
ATOM   2920 C CA  . GLU B 2 161 ? 33.283    -19.422   -12.169   1     21.8492  ? 148 GLU H CA  1 
ATOM   2921 C C   . GLU B 2 161 ? 33.403    -19.8     -10.672   1     20.62069 ? 148 GLU H C   1 
ATOM   2922 O O   . GLU B 2 161 ? 33.202    -20.93    -10.305   1     22.28282 ? 148 GLU H O   1 
ATOM   2923 C CB  . GLU B 2 161 ? 31.92     -18.833   -12.459   1     15.36403 ? 148 GLU H CB  1 
ATOM   2924 C CG  . GLU B 2 161 ? 31.73     -18.286   -13.857   1     24.71788 ? 148 GLU H CG  1 
ATOM   2925 C CD  . GLU B 2 161 ? 30.563    -17.322   -13.94    1     36.03924 ? 148 GLU H CD  1 
ATOM   2926 O OE1 . GLU B 2 161 ? 30.725    -16.157   -13.542   1     29.22911 ? 148 GLU H OE1 1 
ATOM   2927 O OE2 . GLU B 2 161 ? 29.481    -17.727   -14.397   1     34.20707 ? 148 GLU H OE2 1 
ATOM   2928 N N   . PRO B 2 162 ? 33.757    -18.855   -9.829    1     18.43271 ? 149 PRO H N   1 
ATOM   2929 C CA  . PRO B 2 162 ? 33.853    -17.427   -10.05    1     24.13983 ? 149 PRO H CA  1 
ATOM   2930 C C   . PRO B 2 162 ? 35.236    -16.805   -9.954    1     26.64153 ? 149 PRO H C   1 
ATOM   2931 O O   . PRO B 2 162 ? 36.183    -17.461   -9.568    1     21.75781 ? 149 PRO H O   1 
ATOM   2932 C CB  . PRO B 2 162 ? 33.078    -16.877   -8.857    1     20.35278 ? 149 PRO H CB  1 
ATOM   2933 C CG  . PRO B 2 162 ? 33.348    -17.857   -7.766    1     23.50585 ? 149 PRO H CG  1 
ATOM   2934 C CD  . PRO B 2 162 ? 33.799    -19.148   -8.39     1     23.58986 ? 149 PRO H CD  1 
ATOM   2935 N N   . VAL B 2 163 ? 35.321    -15.531   -10.296   1     23.8597  ? 150 VAL H N   1 
ATOM   2936 C CA  . VAL B 2 163 ? 36.551    -14.794   -10.137   1     24.22144 ? 150 VAL H CA  1 
ATOM   2937 C C   . VAL B 2 163 ? 36.238    -13.522   -9.393    1     30.24825 ? 150 VAL H C   1 
ATOM   2938 O O   . VAL B 2 163 ? 35.249    -12.863   -9.654    1     25.51898 ? 150 VAL H O   1 
ATOM   2939 C CB  . VAL B 2 163 ? 37.221    -14.437   -11.467   1     29.42201 ? 150 VAL H CB  1 
ATOM   2940 C CG1 . VAL B 2 163 ? 38.052    -13.177   -11.337   1     29.07882 ? 150 VAL H CG1 1 
ATOM   2941 C CG2 . VAL B 2 163 ? 38.042    -15.602   -11.987   1     22.2522  ? 150 VAL H CG2 1 
ATOM   2942 N N   . THR B 2 164 ? 37.066    -13.209   -8.431    1     29.99385 ? 151 THR H N   1 
ATOM   2943 C CA  . THR B 2 164 ? 36.908    -11.968   -7.702    1     28.88791 ? 151 THR H CA  1 
ATOM   2944 C C   . THR B 2 164 ? 38.059    -11.029   -8.058    1     26.52766 ? 151 THR H C   1 
ATOM   2945 O O   . THR B 2 164 ? 39.159    -11.462   -8.304    1     27.01738 ? 151 THR H O   1 
ATOM   2946 C CB  . THR B 2 164 ? 36.809    -12.218   -6.191    1     33.27046 ? 151 THR H CB  1 
ATOM   2947 O OG1 . THR B 2 164 ? 37.737    -13.234   -5.812    1     42.12693 ? 151 THR H OG1 1 
ATOM   2948 C CG2 . THR B 2 164 ? 35.408    -12.665   -5.83     1     36.34065 ? 151 THR H CG2 1 
ATOM   2949 N N   . VAL B 2 165 ? 37.77     -9.746    -8.122    1     30.63097 ? 152 VAL H N   1 
ATOM   2950 C CA  . VAL B 2 165 ? 38.766    -8.771    -8.501    1     26.69232 ? 152 VAL H CA  1 
ATOM   2951 C C   . VAL B 2 165 ? 38.794    -7.606    -7.531    1     26.00439 ? 152 VAL H C   1 
ATOM   2952 O O   . VAL B 2 165 ? 37.767    -7.095    -7.143    1     33.14077 ? 152 VAL H O   1 
ATOM   2953 C CB  . VAL B 2 165 ? 38.529    -8.262    -9.938    1     24.76238 ? 152 VAL H CB  1 
ATOM   2954 C CG1 . VAL B 2 165 ? 39.584    -7.24     -10.325   1     25.90483 ? 152 VAL H CG1 1 
ATOM   2955 C CG2 . VAL B 2 165 ? 38.473    -9.409    -10.929   1     22.48888 ? 152 VAL H CG2 1 
ATOM   2956 N N   . SER B 2 166 ? 39.965    -7.224    -7.112    1     28.93269 ? 153 SER H N   1 
ATOM   2957 C CA  . SER B 2 166 ? 40.131    -6.084    -6.234    1     31.81336 ? 153 SER H CA  1 
ATOM   2958 C C   . SER B 2 166 ? 41.124    -5.141    -6.868    1     27.57677 ? 153 SER H C   1 
ATOM   2959 O O   . SER B 2 166 ? 41.831    -5.518    -7.775    1     28.7407  ? 153 SER H O   1 
ATOM   2960 C CB  . SER B 2 166 ? 40.632    -6.519    -4.852    1     37.29447 ? 153 SER H CB  1 
ATOM   2961 O OG  . SER B 2 166 ? 41.985    -6.897    -4.877    1     40.17311 ? 153 SER H OG  1 
ATOM   2962 N N   . TRP B 2 167 ? 41.167    -3.919    -6.378    1     29.17143 ? 154 TRP H N   1 
ATOM   2963 C CA  . TRP B 2 167 ? 42.104    -2.942    -6.882    1     31.83546 ? 154 TRP H CA  1 
ATOM   2964 C C   . TRP B 2 167 ? 42.971    -2.365    -5.745    1     34.21478 ? 154 TRP H C   1 
ATOM   2965 O O   . TRP B 2 167 ? 42.454    -2.001    -4.7      1     26.59402 ? 154 TRP H O   1 
ATOM   2966 C CB  . TRP B 2 167 ? 41.365    -1.857    -7.653    1     27.34862 ? 154 TRP H CB  1 
ATOM   2967 C CG  . TRP B 2 167 ? 40.92     -2.277    -9        1     27.91013 ? 154 TRP H CG  1 
ATOM   2968 C CD1 . TRP B 2 167 ? 39.713    -2.798    -9.337    1     22.00867 ? 154 TRP H CD1 1 
ATOM   2969 C CD2 . TRP B 2 167 ? 41.68     -2.21     -10.205   1     28.23559 ? 154 TRP H CD2 1 
ATOM   2970 N NE1 . TRP B 2 167 ? 39.67     -3.063    -10.677   1     25.63335 ? 154 TRP H NE1 1 
ATOM   2971 C CE2 . TRP B 2 167 ? 40.868    -2.712    -11.236   1     25.43493 ? 154 TRP H CE2 1 
ATOM   2972 C CE3 . TRP B 2 167 ? 42.968    -1.774    -10.513   1     21.11337 ? 154 TRP H CE3 1 
ATOM   2973 C CZ2 . TRP B 2 167 ? 41.3      -2.789    -12.55    1     25.27415 ? 154 TRP H CZ2 1 
ATOM   2974 C CZ3 . TRP B 2 167 ? 43.396    -1.854    -11.811   1     26.79001 ? 154 TRP H CZ3 1 
ATOM   2975 C CH2 . TRP B 2 167 ? 42.565    -2.356    -12.818   1     33.46629 ? 154 TRP H CH2 1 
ATOM   2976 N N   . ASN B 2 168 ? 44.274    -2.318    -5.958    1     28.60218 ? 155 ASN H N   1 
ATOM   2977 C CA  . ASN B 2 168 ? 45.21     -1.843    -4.938    1     31.86529 ? 155 ASN H CA  1 
ATOM   2978 C C   . ASN B 2 168 ? 44.908    -2.489    -3.589    1     37.73653 ? 155 ASN H C   1 
ATOM   2979 O O   . ASN B 2 168 ? 44.805    -1.807    -2.588    1     37.04815 ? 155 ASN H O   1 
ATOM   2980 C CB  . ASN B 2 168 ? 45.23     -0.324    -4.896    1     35.14965 ? 155 ASN H CB  1 
ATOM   2981 C CG  . ASN B 2 168 ? 45.704    0.29      -6.198    1     35.22841 ? 155 ASN H CG  1 
ATOM   2982 O OD1 . ASN B 2 168 ? 46.376    -0.352    -6.995    1     32.97603 ? 155 ASN H OD1 1 
ATOM   2983 N ND2 . ASN B 2 168 ? 45.361    1.549     -6.409    1     40.86732 ? 155 ASN H ND2 1 
ATOM   2984 N N   . SER B 2 169 ? 44.71     -3.798    -3.597    1     32.04328 ? 156 SER H N   1 
ATOM   2985 C CA  . SER B 2 169 ? 44.469    -4.556    -2.384    1     30.68459 ? 156 SER H CA  1 
ATOM   2986 C C   . SER B 2 169 ? 43.353    -3.997    -1.555    1     43.83037 ? 156 SER H C   1 
ATOM   2987 O O   . SER B 2 169 ? 43.41     -4.035    -0.34     1     47.65206 ? 156 SER H O   1 
ATOM   2988 C CB  . SER B 2 169 ? 45.766    -4.683    -1.593    1     35.06649 ? 156 SER H CB  1 
ATOM   2989 O OG  . SER B 2 169 ? 46.76     -5.314    -2.371    1     37.22033 ? 156 SER H OG  1 
ATOM   2990 N N   . GLY B 2 170 ? 42.312    -3.512    -2.205    1     39.78077 ? 157 GLY H N   1 
ATOM   2991 C CA  . GLY B 2 170 ? 41.156    -3.041    -1.49     1     30.95675 ? 157 GLY H CA  1 
ATOM   2992 C C   . GLY B 2 170 ? 41.112    -1.595    -1.108    1     27.29193 ? 157 GLY H C   1 
ATOM   2993 O O   . GLY B 2 170 ? 40.127    -1.14     -0.571    1     38.66814 ? 157 GLY H O   1 
ATOM   2994 N N   . ALA B 2 171 ? 42.176    -0.88     -1.382    1     28.69547 ? 158 ALA H N   1 
ATOM   2995 C CA  . ALA B 2 171 ? 42.227    0.538     -1.072    1     39.18514 ? 158 ALA H CA  1 
ATOM   2996 C C   . ALA B 2 171 ? 41.46     1.316     -2.105    1     41.98984 ? 158 ALA H C   1 
ATOM   2997 O O   . ALA B 2 171 ? 40.988    2.406     -1.823    1     40.02884 ? 158 ALA H O   1 
ATOM   2998 C CB  . ALA B 2 171 ? 43.658    1.024     -1.027    1     35.26904 ? 158 ALA H CB  1 
ATOM   2999 N N   . LEU B 2 172 ? 41.331    0.745     -3.294    1     37.34827 ? 159 LEU H N   1 
ATOM   3000 C CA  . LEU B 2 172 ? 40.57     1.395     -4.348    1     35.94803 ? 159 LEU H CA  1 
ATOM   3001 C C   . LEU B 2 172 ? 39.2      0.765     -4.555    1     35.12582 ? 159 LEU H C   1 
ATOM   3002 O O   . LEU B 2 172 ? 39.1      -0.334    -5.061    1     30.54729 ? 159 LEU H O   1 
ATOM   3003 C CB  . LEU B 2 172 ? 41.371    1.4       -5.634    1     37.8573  ? 159 LEU H CB  1 
ATOM   3004 C CG  . LEU B 2 172 ? 40.712    2.101     -6.825    1     37.16683 ? 159 LEU H CG  1 
ATOM   3005 C CD1 . LEU B 2 172 ? 40.16     3.464     -6.441    1     30.24834 ? 159 LEU H CD1 1 
ATOM   3006 C CD2 . LEU B 2 172 ? 41.658    2.205     -8.006    1     23.64988 ? 159 LEU H CD2 1 
ATOM   3007 N N   . THR B 2 173 ? 38.161    1.485     -4.177    1     32.23014 ? 160 THR H N   1 
ATOM   3008 C CA  . THR B 2 173 ? 36.814    0.975     -4.269    1     34.43999 ? 160 THR H CA  1 
ATOM   3009 C C   . THR B 2 173 ? 35.896    1.833     -5.125    1     45.21443 ? 160 THR H C   1 
ATOM   3010 O O   . THR B 2 173 ? 35.122    1.32      -5.91     1     32.21323 ? 160 THR H O   1 
ATOM   3011 C CB  . THR B 2 173 ? 36.201    0.861     -2.865    1     38.05044 ? 160 THR H CB  1 
ATOM   3012 O OG1 . THR B 2 173 ? 36.38     2.085     -2.155    1     46.44648 ? 160 THR H OG1 1 
ATOM   3013 C CG2 . THR B 2 173 ? 36.861    -0.274    -2.099    1     33.02465 ? 160 THR H CG2 1 
ATOM   3014 N N   . SER B 2 174 ? 35.981    3.147     -4.954    1     37.35507 ? 161 SER H N   1 
ATOM   3015 C CA  . SER B 2 174 ? 35.106    4.051     -5.686    1     34.62015 ? 161 SER H CA  1 
ATOM   3016 C C   . SER B 2 174 ? 35.355    4.047     -7.189    1     31.38577 ? 161 SER H C   1 
ATOM   3017 O O   . SER B 2 174 ? 36.491    4.088     -7.623    1     30.79883 ? 161 SER H O   1 
ATOM   3018 C CB  . SER B 2 174 ? 35.221    5.468     -5.115    1     42.71913 ? 161 SER H CB  1 
ATOM   3019 O OG  . SER B 2 174 ? 34.663    5.546     -3.818    1     54.24668 ? 161 SER H OG  1 
ATOM   3020 N N   . GLY B 2 175 ? 34.285    3.979     -7.965    1     23.55273 ? 162 GLY H N   1 
ATOM   3021 C CA  . GLY B 2 175 ? 34.406    3.96      -9.408    1     30.28062 ? 162 GLY H CA  1 
ATOM   3022 C C   . GLY B 2 175 ? 34.759    2.642     -10.054   1     26.39265 ? 162 GLY H C   1 
ATOM   3023 O O   . GLY B 2 175 ? 34.926    2.57      -11.252   1     30.10102 ? 162 GLY H O   1 
ATOM   3024 N N   . VAL B 2 176 ? 34.891    1.605     -9.257    1     24.70551 ? 163 VAL H N   1 
ATOM   3025 C CA  . VAL B 2 176 ? 35.205    0.286     -9.782    1     28.54267 ? 163 VAL H CA  1 
ATOM   3026 C C   . VAL B 2 176 ? 33.963    -0.459    -10.316   1     25.60388 ? 163 VAL H C   1 
ATOM   3027 O O   . VAL B 2 176 ? 32.928    -0.49     -9.678    1     25.28931 ? 163 VAL H O   1 
ATOM   3028 C CB  . VAL B 2 176 ? 35.943    -0.597    -8.739    1     21.67482 ? 163 VAL H CB  1 
ATOM   3029 C CG1 . VAL B 2 176 ? 36.091    -2.019    -9.252    1     21.7493  ? 163 VAL H CG1 1 
ATOM   3030 C CG2 . VAL B 2 176 ? 37.288    0         -8.376    1     22.88226 ? 163 VAL H CG2 1 
ATOM   3031 N N   . HIS B 2 177 ? 34.073    -1.028    -11.489   1     23.70581 ? 164 HIS H N   1 
ATOM   3032 C CA  . HIS B 2 177 ? 33.003    -1.843    -12.015   1     19.81732 ? 164 HIS H CA  1 
ATOM   3033 C C   . HIS B 2 177 ? 33.615    -3.172    -12.442   1     18.17066 ? 164 HIS H C   1 
ATOM   3034 O O   . HIS B 2 177 ? 34.454    -3.219    -13.314   1     18.87359 ? 164 HIS H O   1 
ATOM   3035 C CB  . HIS B 2 177 ? 32.274    -1.173    -13.17    1     16.09406 ? 164 HIS H CB  1 
ATOM   3036 C CG  . HIS B 2 177 ? 31.537    0.074     -12.816   1     17.97079 ? 164 HIS H CG  1 
ATOM   3037 N ND1 . HIS B 2 177 ? 30.529    0.107     -11.884   1     20.35672 ? 164 HIS H ND1 1 
ATOM   3038 C CD2 . HIS B 2 177 ? 31.621    1.324     -13.323   1     24.37923 ? 164 HIS H CD2 1 
ATOM   3039 C CE1 . HIS B 2 177 ? 30.044    1.331     -11.809   1     25.54037 ? 164 HIS H CE1 1 
ATOM   3040 N NE2 . HIS B 2 177 ? 30.689    2.088     -12.673   1     26.54675 ? 164 HIS H NE2 1 
ATOM   3041 N N   . THR B 2 178 ? 33.202    -4.244    -11.804   1     19.35302 ? 165 THR H N   1 
ATOM   3042 C CA  . THR B 2 178 ? 33.66     -5.56     -12.193   1     15.3577  ? 165 THR H CA  1 
ATOM   3043 C C   . THR B 2 178 ? 32.476    -6.263    -12.841   1     15.71363 ? 165 THR H C   1 
ATOM   3044 O O   . THR B 2 178 ? 31.541    -6.628    -12.183   1     19.89278 ? 165 THR H O   1 
ATOM   3045 C CB  . THR B 2 178 ? 34.323    -6.33     -11.016   1     22.73548 ? 165 THR H CB  1 
ATOM   3046 O OG1 . THR B 2 178 ? 35.45     -5.6      -10.525   1     21.50968 ? 165 THR H OG1 1 
ATOM   3047 C CG2 . THR B 2 178 ? 34.761    -7.71     -11.465   1     20.45312 ? 165 THR H CG2 1 
ATOM   3048 N N   . PHE B 2 179 ? 32.53     -6.436    -14.138   1     17.82744 ? 166 PHE H N   1 
ATOM   3049 C CA  . PHE B 2 179 ? 31.416    -6.991    -14.88    1     16.93077 ? 166 PHE H CA  1 
ATOM   3050 C C   . PHE B 2 179 ? 31.12     -8.471    -14.693   1     21.04983 ? 166 PHE H C   1 
ATOM   3051 O O   . PHE B 2 179 ? 32.005    -9.251    -14.434   1     20.36112 ? 166 PHE H O   1 
ATOM   3052 C CB  . PHE B 2 179 ? 31.627    -6.711    -16.364   1     16.97117 ? 166 PHE H CB  1 
ATOM   3053 C CG  . PHE B 2 179 ? 31.534    -5.261    -16.734   1     17.22435 ? 166 PHE H CG  1 
ATOM   3054 C CD1 . PHE B 2 179 ? 30.316    -4.699    -17.053   1     20.67709 ? 166 PHE H CD1 1 
ATOM   3055 C CD2 . PHE B 2 179 ? 32.662    -4.47     -16.782   1     14.87669 ? 166 PHE H CD2 1 
ATOM   3056 C CE1 . PHE B 2 179 ? 30.219    -3.37     -17.4     1     19.52462 ? 166 PHE H CE1 1 
ATOM   3057 C CE2 . PHE B 2 179 ? 32.575    -3.138    -17.126   1     19.25948 ? 166 PHE H CE2 1 
ATOM   3058 C CZ  . PHE B 2 179 ? 31.35     -2.587    -17.439   1     19.42559 ? 166 PHE H CZ  1 
ATOM   3059 N N   . PRO B 2 180 ? 29.846    -8.829    -14.818   1     19.63071 ? 167 PRO H N   1 
ATOM   3060 C CA  . PRO B 2 180 ? 29.516    -10.245   -14.793   1     16.85105 ? 167 PRO H CA  1 
ATOM   3061 C C   . PRO B 2 180 ? 30.221    -10.946   -15.925   1     22.88503 ? 167 PRO H C   1 
ATOM   3062 O O   . PRO B 2 180 ? 30.394    -10.384   -16.985   1     21.18267 ? 167 PRO H O   1 
ATOM   3063 C CB  . PRO B 2 180 ? 28.025    -10.252   -15.045   1     19.32653 ? 167 PRO H CB  1 
ATOM   3064 C CG  . PRO B 2 180 ? 27.551    -8.931    -14.558   1     23.8295  ? 167 PRO H CG  1 
ATOM   3065 C CD  . PRO B 2 180 ? 28.652    -7.976    -14.874   1     18.40459 ? 167 PRO H CD  1 
ATOM   3066 N N   . ALA B 2 181 ? 30.639    -12.163   -15.686   1     15.84813 ? 168 ALA H N   1 
ATOM   3067 C CA  . ALA B 2 181 ? 31.313    -12.912   -16.695   1     18.85764 ? 168 ALA H CA  1 
ATOM   3068 C C   . ALA B 2 181 ? 30.452    -13.329   -17.862   1     23.88684 ? 168 ALA H C   1 
ATOM   3069 O O   . ALA B 2 181 ? 29.263    -13.521   -17.723   1     20.20915 ? 168 ALA H O   1 
ATOM   3070 C CB  . ALA B 2 181 ? 31.922    -14.146   -16.081   1     21.94535 ? 168 ALA H CB  1 
ATOM   3071 N N   . VAL B 2 182 ? 31.07     -13.429   -19.013   1     19.92527 ? 169 VAL H N   1 
ATOM   3072 C CA  . VAL B 2 182 ? 30.376    -13.93    -20.168   1     30.54581 ? 169 VAL H CA  1 
ATOM   3073 C C   . VAL B 2 182 ? 30.939    -15.315   -20.539   1     28.94948 ? 169 VAL H C   1 
ATOM   3074 O O   . VAL B 2 182 ? 32.124    -15.574   -20.386   1     24.15026 ? 169 VAL H O   1 
ATOM   3075 C CB  . VAL B 2 182 ? 30.451    -12.957   -21.363   1     26.05267 ? 169 VAL H CB  1 
ATOM   3076 C CG1 . VAL B 2 182 ? 29.753    -11.648   -21.05    1     26.44636 ? 169 VAL H CG1 1 
ATOM   3077 C CG2 . VAL B 2 182 ? 31.887    -12.75    -21.806   1     28.41304 ? 169 VAL H CG2 1 
ATOM   3078 N N   . LEU B 2 183 ? 30.077    -16.205   -20.968   1     23.59998 ? 170 LEU H N   1 
ATOM   3079 C CA  . LEU B 2 183 ? 30.544    -17.497   -21.41    1     26.80171 ? 170 LEU H CA  1 
ATOM   3080 C C   . LEU B 2 183 ? 30.94     -17.407   -22.859   1     27.24984 ? 170 LEU H C   1 
ATOM   3081 O O   . LEU B 2 183 ? 30.157    -17       -23.687   1     33.05248 ? 170 LEU H O   1 
ATOM   3082 C CB  . LEU B 2 183 ? 29.479    -18.56    -21.238   1     23.0821  ? 170 LEU H CB  1 
ATOM   3083 C CG  . LEU B 2 183 ? 29.83     -19.997   -21.61    1     24.64278 ? 170 LEU H CG  1 
ATOM   3084 C CD1 . LEU B 2 183 ? 30.862    -20.554   -20.652   1     27.25256 ? 170 LEU H CD1 1 
ATOM   3085 C CD2 . LEU B 2 183 ? 28.576    -20.849   -21.58    1     25.83547 ? 170 LEU H CD2 1 
ATOM   3086 N N   . GLN B 2 184 ? 32.149    -17.807   -23.158   1     26.70296 ? 171 GLN H N   1 
ATOM   3087 C CA  . GLN B 2 184 ? 32.628    -17.787   -24.519   1     34.93447 ? 171 GLN H CA  1 
ATOM   3088 C C   . GLN B 2 184 ? 32.305    -19.055   -25.312   1     32.01222 ? 171 GLN H C   1 
ATOM   3089 O O   . GLN B 2 184 ? 31.859    -20.031   -24.753   1     33.10078 ? 171 GLN H O   1 
ATOM   3090 C CB  . GLN B 2 184 ? 34.137    -17.533   -24.522   1     38.52265 ? 171 GLN H CB  1 
ATOM   3091 C CG  . GLN B 2 184 ? 34.569    -16.211   -23.918   1     32.57629 ? 171 GLN H CG  1 
ATOM   3092 C CD  . GLN B 2 184 ? 36.048    -16.18    -23.605   1     36.58118 ? 171 GLN H CD  1 
ATOM   3093 O OE1 . GLN B 2 184 ? 36.764    -15.285   -24.035   1     40.37043 ? 171 GLN H OE1 1 
ATOM   3094 N NE2 . GLN B 2 184 ? 36.512    -17.164   -22.86    1     34.29302 ? 171 GLN H NE2 1 
ATOM   3095 N N   . SER B 2 185 ? 32.534    -19.02    -26.614   1     39.06509 ? 172 SER H N   1 
ATOM   3096 C CA  . SER B 2 185 ? 32.312    -20.198   -27.474   1     46.29004 ? 172 SER H CA  1 
ATOM   3097 C C   . SER B 2 185 ? 33.136    -21.355   -27.027   1     38.34584 ? 172 SER H C   1 
ATOM   3098 O O   . SER B 2 185 ? 32.713    -22.484   -27.127   1     45.07545 ? 172 SER H O   1 
ATOM   3099 C CB  . SER B 2 185 ? 32.672    -19.903   -28.929   1     37.94787 ? 172 SER H CB  1 
ATOM   3100 O OG  . SER B 2 185 ? 34.064    -19.828   -29.12    1     53.01578 ? 172 SER H OG  1 
ATOM   3101 N N   . SER B 2 186 ? 34.316    -21.06    -26.51    1     38.75091 ? 173 SER H N   1 
ATOM   3102 C CA  . SER B 2 186 ? 35.208    -22.125   -26.067   1     34.83241 ? 173 SER H CA  1 
ATOM   3103 C C   . SER B 2 186 ? 34.742    -22.799   -24.784   1     37.02777 ? 173 SER H C   1 
ATOM   3104 O O   . SER B 2 186 ? 35.405    -23.736   -24.326   1     36.93271 ? 173 SER H O   1 
ATOM   3105 C CB  . SER B 2 186 ? 36.621    -21.571   -25.868   1     33.27379 ? 173 SER H CB  1 
ATOM   3106 O OG  . SER B 2 186 ? 36.625    -20.524   -24.913   1     29.12644 ? 173 SER H OG  1 
ATOM   3107 N N   . GLY B 2 187 ? 33.686    -22.29    -24.167   1     37.14494 ? 174 GLY H N   1 
ATOM   3108 C CA  . GLY B 2 187 ? 33.192    -22.843   -22.927   1     30.523   ? 174 GLY H CA  1 
ATOM   3109 C C   . GLY B 2 187 ? 33.864    -22.274   -21.711   1     32.1692  ? 174 GLY H C   1 
ATOM   3110 O O   . GLY B 2 187 ? 33.473    -22.579   -20.599   1     34.63052 ? 174 GLY H O   1 
ATOM   3111 N N   . LEU B 2 188 ? 34.881    -21.467   -21.92    1     30.15073 ? 175 LEU H N   1 
ATOM   3112 C CA  . LEU B 2 188 ? 35.545    -20.814   -20.824   1     27.56682 ? 175 LEU H CA  1 
ATOM   3113 C C   . LEU B 2 188 ? 34.939    -19.445   -20.57    1     32.27303 ? 175 LEU H C   1 
ATOM   3114 O O   . LEU B 2 188 ? 34.274    -18.881   -21.424   1     27.45359 ? 175 LEU H O   1 
ATOM   3115 C CB  . LEU B 2 188 ? 37.034    -20.696   -21.093   1     29.71512 ? 175 LEU H CB  1 
ATOM   3116 C CG  . LEU B 2 188 ? 37.73     -21.976   -21.537   1     35.03365 ? 175 LEU H CG  1 
ATOM   3117 C CD1 . LEU B 2 188 ? 39.106    -21.673   -22.095   1     23.50497 ? 175 LEU H CD1 1 
ATOM   3118 C CD2 . LEU B 2 188 ? 37.796    -22.96    -20.385   1     27.6605  ? 175 LEU H CD2 1 
ATOM   3119 N N   . TYR B 2 189 ? 35.185    -18.911   -19.399   1     28.34758 ? 176 TYR H N   1 
ATOM   3120 C CA  . TYR B 2 189 ? 34.619    -17.639   -19.037   1     24.9565  ? 176 TYR H CA  1 
ATOM   3121 C C   . TYR B 2 189 ? 35.583    -16.47    -19.146   1     25.75516 ? 176 TYR H C   1 
ATOM   3122 O O   . TYR B 2 189 ? 36.781    -16.657   -19.146   1     22.55935 ? 176 TYR H O   1 
ATOM   3123 C CB  . TYR B 2 189 ? 34.093    -17.715   -17.609   1     18.56285 ? 176 TYR H CB  1 
ATOM   3124 C CG  . TYR B 2 189 ? 32.894    -18.594   -17.417   1     26.22456 ? 176 TYR H CG  1 
ATOM   3125 C CD1 . TYR B 2 189 ? 33.037    -19.931   -17.106   1     24.80637 ? 176 TYR H CD1 1 
ATOM   3126 C CD2 . TYR B 2 189 ? 31.614    -18.082   -17.531   1     24.1148  ? 176 TYR H CD2 1 
ATOM   3127 C CE1 . TYR B 2 189 ? 31.938    -20.741   -16.929   1     28.32669 ? 176 TYR H CE1 1 
ATOM   3128 C CE2 . TYR B 2 189 ? 30.507    -18.884   -17.354   1     30.63428 ? 176 TYR H CE2 1 
ATOM   3129 C CZ  . TYR B 2 189 ? 30.676    -20.212   -17.053   1     31.24934 ? 176 TYR H CZ  1 
ATOM   3130 O OH  . TYR B 2 189 ? 29.588    -21.014   -16.876   1     29.44178 ? 176 TYR H OH  1 
ATOM   3131 N N   . SER B 2 190 ? 35.047    -15.285   -19.274   1     21.49555 ? 177 SER H N   1 
ATOM   3132 C CA  A SER B 2 190 ? 35.871    -14.082   -19.318   0.641 23.69593 ? 177 SER H CA  1 
ATOM   3133 C CA  B SER B 2 190 ? 35.871    -14.074   -19.318   0.359 23.71268 ? 177 SER H CA  1 
ATOM   3134 C C   . SER B 2 190 ? 35.125    -12.841   -18.761   1     22.56183 ? 177 SER H C   1 
ATOM   3135 O O   . SER B 2 190 ? 33.865    -12.651   -18.774   1     21.80524 ? 177 SER H O   1 
ATOM   3136 C CB  A SER B 2 190 ? 36.369    -13.794   -20.737   0.641 25.29502 ? 177 SER H CB  1 
ATOM   3137 C CB  B SER B 2 190 ? 36.362    -13.744   -20.731   0.359 25.36994 ? 177 SER H CB  1 
ATOM   3138 O OG  A SER B 2 190 ? 37.065    -12.569   -20.801   0.641 26.55071 ? 177 SER H OG  1 
ATOM   3139 O OG  B SER B 2 190 ? 37.34     -14.66    -21.169   0.359 29.42364 ? 177 SER H OG  1 
ATOM   3140 N N   . LEU B 2 191 ? 35.901    -11.973   -18.162   1     21.40761 ? 178 LEU H N   1 
ATOM   3141 C CA  . LEU B 2 191 ? 35.307    -10.749   -17.658   1     28.20039 ? 178 LEU H CA  1 
ATOM   3142 C C   . LEU B 2 191 ? 36.313    -9.616    -17.638   1     22.09588 ? 178 LEU H C   1 
ATOM   3143 O O   . LEU B 2 191 ? 37.491    -9.829    -17.836   1     20.7354  ? 178 LEU H O   1 
ATOM   3144 C CB  . LEU B 2 191 ? 34.695    -10.955   -16.264   1     20.45268 ? 178 LEU H CB  1 
ATOM   3145 C CG  . LEU B 2 191 ? 35.558    -11.264   -15.037   1     32.80622 ? 178 LEU H CG  1 
ATOM   3146 C CD1 . LEU B 2 191 ? 36.353    -10.055   -14.573   1     21.72988 ? 178 LEU H CD1 1 
ATOM   3147 C CD2 . LEU B 2 191 ? 34.668    -11.75    -13.907   1     22.57497 ? 178 LEU H CD2 1 
ATOM   3148 N N   . SER B 2 192 ? 35.824    -8.424    -17.41    1     20.22133 ? 179 SER H N   1 
ATOM   3149 C CA  . SER B 2 192 ? 36.705    -7.286    -17.25    1     23.91439 ? 179 SER H CA  1 
ATOM   3150 C C   . SER B 2 192 ? 36.382    -6.478    -15.999   1     21.34852 ? 179 SER H C   1 
ATOM   3151 O O   . SER B 2 192 ? 35.241    -6.429    -15.577   1     17.17352 ? 179 SER H O   1 
ATOM   3152 C CB  . SER B 2 192 ? 36.675    -6.38     -18.485   1     19.79806 ? 179 SER H CB  1 
ATOM   3153 O OG  . SER B 2 192 ? 37.275    -6.983    -19.604   1     32.88628 ? 179 SER H OG  1 
ATOM   3154 N N   . SER B 2 193 ? 37.397    -5.902    -15.377   1     19.82507 ? 180 SER H N   1 
ATOM   3155 C CA  . SER B 2 193 ? 37.183    -5.012    -14.256   1     20.31886 ? 180 SER H CA  1 
ATOM   3156 C C   . SER B 2 193 ? 37.765    -3.661    -14.638   1     29.03335 ? 180 SER H C   1 
ATOM   3157 O O   . SER B 2 193 ? 38.841    -3.574    -15.183   1     21.51705 ? 180 SER H O   1 
ATOM   3158 C CB  . SER B 2 193 ? 37.758    -5.508    -12.91    1     20.15535 ? 180 SER H CB  1 
ATOM   3159 O OG  . SER B 2 193 ? 37.432    -4.639    -11.853   1     22.11292 ? 180 SER H OG  1 
ATOM   3160 N N   . VAL B 2 194 ? 37.027    -2.619    -14.333   1     24.98644 ? 181 VAL H N   1 
ATOM   3161 C CA  . VAL B 2 194 ? 37.453    -1.296    -14.663   1     21.99437 ? 181 VAL H CA  1 
ATOM   3162 C C   . VAL B 2 194 ? 37.308    -0.315    -13.515   1     21.99371 ? 181 VAL H C   1 
ATOM   3163 O O   . VAL B 2 194 ? 36.592    -0.559    -12.571   1     21.16525 ? 181 VAL H O   1 
ATOM   3164 C CB  . VAL B 2 194 ? 36.648    -0.783    -15.868   1     26.19942 ? 181 VAL H CB  1 
ATOM   3165 C CG1 . VAL B 2 194 ? 36.913    -1.625    -17.103   1     17.5482  ? 181 VAL H CG1 1 
ATOM   3166 C CG2 . VAL B 2 194 ? 35.168    -0.713    -15.536   1     17.26198 ? 181 VAL H CG2 1 
ATOM   3167 N N   . VAL B 2 195 ? 37.996    0.797     -13.623   1     21.65456 ? 182 VAL H N   1 
ATOM   3168 C CA  . VAL B 2 195 ? 37.913    1.829     -12.632   1     23.98206 ? 182 VAL H CA  1 
ATOM   3169 C C   . VAL B 2 195 ? 38.103    3.196     -13.276   1     26.61368 ? 182 VAL H C   1 
ATOM   3170 O O   . VAL B 2 195 ? 38.913    3.357     -14.162   1     23.86766 ? 182 VAL H O   1 
ATOM   3171 C CB  . VAL B 2 195 ? 38.945    1.653     -11.491   1     30.00223 ? 182 VAL H CB  1 
ATOM   3172 C CG1 . VAL B 2 195 ? 40.355    1.581     -12.025   1     30.50545 ? 182 VAL H CG1 1 
ATOM   3173 C CG2 . VAL B 2 195 ? 38.802    2.751     -10.457   1     27.08484 ? 182 VAL H CG2 1 
ATOM   3174 N N   . THR B 2 196 ? 37.307    4.145     -12.83    1     26.71194 ? 183 THR H N   1 
ATOM   3175 C CA  . THR B 2 196 ? 37.454    5.511     -13.308   1     30.51144 ? 183 THR H CA  1 
ATOM   3176 C C   . THR B 2 196 ? 38.212    6.292     -12.256   1     29.99637 ? 183 THR H C   1 
ATOM   3177 O O   . THR B 2 196 ? 37.85     6.28      -11.102   1     32.125   ? 183 THR H O   1 
ATOM   3178 C CB  . THR B 2 196 ? 36.113    6.171     -13.654   1     24.13732 ? 183 THR H CB  1 
ATOM   3179 O OG1 . THR B 2 196 ? 35.237    6.087     -12.528   1     39.13748 ? 183 THR H OG1 1 
ATOM   3180 C CG2 . THR B 2 196 ? 35.482    5.482     -14.838   1     28.72972 ? 183 THR H CG2 1 
ATOM   3181 N N   . VAL B 2 197 ? 39.27     6.959     -12.67    1     36.61198 ? 184 VAL H N   1 
ATOM   3182 C CA  . VAL B 2 197 ? 40.115    7.725     -11.753   1     40.0963  ? 184 VAL H CA  1 
ATOM   3183 C C   . VAL B 2 197 ? 40.436    9.133     -12.231   1     43.15879 ? 184 VAL H C   1 
ATOM   3184 O O   . VAL B 2 197 ? 40.304    9.442     -13.398   1     40.25419 ? 184 VAL H O   1 
ATOM   3185 C CB  . VAL B 2 197 ? 41.474    7.033     -11.547   1     38.05531 ? 184 VAL H CB  1 
ATOM   3186 C CG1 . VAL B 2 197 ? 41.298    5.716     -10.813   1     32.07079 ? 184 VAL H CG1 1 
ATOM   3187 C CG2 . VAL B 2 197 ? 42.18     6.836     -12.875   1     31.66057 ? 184 VAL H CG2 1 
ATOM   3188 N N   . PRO B 2 198 ? 40.906    9.974     -11.314   1     46.31137 ? 185 PRO H N   1 
ATOM   3189 C CA  . PRO B 2 198 ? 41.324    11.298    -11.738   1     42.34138 ? 185 PRO H CA  1 
ATOM   3190 C C   . PRO B 2 198 ? 42.553    11.215    -12.597   1     42.11357 ? 185 PRO H C   1 
ATOM   3191 O O   . PRO B 2 198 ? 43.521    10.596    -12.219   1     45.87811 ? 185 PRO H O   1 
ATOM   3192 C CB  . PRO B 2 198 ? 41.649    11.985    -10.433   1     46.13095 ? 185 PRO H CB  1 
ATOM   3193 C CG  . PRO B 2 198 ? 40.93     11.222    -9.378    1     44.38583 ? 185 PRO H CG  1 
ATOM   3194 C CD  . PRO B 2 198 ? 40.951    9.813     -9.855    1     40.84596 ? 185 PRO H CD  1 
ATOM   3195 N N   . SER B 2 199 ? 42.49     11.796    -13.771   1     35.94203 ? 186 SER H N   1 
ATOM   3196 C CA  . SER B 2 199 ? 43.626    11.811    -14.663   1     48.69194 ? 186 SER H CA  1 
ATOM   3197 C C   . SER B 2 199 ? 44.826    12.516    -14.058   1     56.16886 ? 186 SER H C   1 
ATOM   3198 O O   . SER B 2 199 ? 45.946    12.286    -14.489   1     52.88394 ? 186 SER H O   1 
ATOM   3199 C CB  . SER B 2 199 ? 43.221    12.512    -15.951   1     55.77408 ? 186 SER H CB  1 
ATOM   3200 O OG  . SER B 2 199 ? 42.448    13.67     -15.676   1     54.89696 ? 186 SER H OG  1 
ATOM   3201 N N   . SER B 2 200 ? 44.597    13.378    -13.074   1     51.91517 ? 187 SER H N   1 
ATOM   3202 C CA  . SER B 2 200 ? 45.685    14.049    -12.366   1     53.32936 ? 187 SER H CA  1 
ATOM   3203 C C   . SER B 2 200 ? 46.484    13.047    -11.57    1     52.28662 ? 187 SER H C   1 
ATOM   3204 O O   . SER B 2 200 ? 47.621    13.293    -11.227   1     60.95709 ? 187 SER H O   1 
ATOM   3205 C CB  . SER B 2 200 ? 45.119    15.105    -11.43    1     51.14144 ? 187 SER H CB  1 
ATOM   3206 O OG  . SER B 2 200 ? 44.158    14.573    -10.544   1     52.47162 ? 187 SER H OG  1 
ATOM   3207 N N   . SER B 2 201 ? 45.881    11.919    -11.26    1     49.71423 ? 188 SER H N   1 
ATOM   3208 C CA  . SER B 2 201 ? 46.556    10.876    -10.513   1     57.68568 ? 188 SER H CA  1 
ATOM   3209 C C   . SER B 2 201 ? 47.294    9.904     -11.391   1     49.82636 ? 188 SER H C   1 
ATOM   3210 O O   . SER B 2 201 ? 48.018    9.061     -10.899   1     48.86924 ? 188 SER H O   1 
ATOM   3211 C CB  . SER B 2 201 ? 45.528    10.076    -9.706    1     47.23791 ? 188 SER H CB  1 
ATOM   3212 O OG  . SER B 2 201 ? 44.713    9.293     -10.548   1     50.19031 ? 188 SER H OG  1 
ATOM   3213 N N   . LEU B 2 202 ? 47.131    10.012    -12.685   1     41.33393 ? 189 LEU H N   1 
ATOM   3214 C CA  . LEU B 2 202 ? 47.707    8.994     -13.544   1     50.47256 ? 189 LEU H CA  1 
ATOM   3215 C C   . LEU B 2 202 ? 49.177    8.721     -13.329   1     57.43816 ? 189 LEU H C   1 
ATOM   3216 O O   . LEU B 2 202 ? 49.54     7.605     -13.016   1     62.48493 ? 189 LEU H O   1 
ATOM   3217 C CB  . LEU B 2 202 ? 47.43     9.329     -15.01    1     45.0771  ? 189 LEU H CB  1 
ATOM   3218 C CG  . LEU B 2 202 ? 45.992    9.022     -15.42    1     60.78675 ? 189 LEU H CG  1 
ATOM   3219 C CD1 . LEU B 2 202 ? 45.846    8.998     -16.932   1     55.06314 ? 189 LEU H CD1 1 
ATOM   3220 C CD2 . LEU B 2 202 ? 45.573    7.684     -14.837   1     50.24477 ? 189 LEU H CD2 1 
ATOM   3221 N N   . GLY B 2 203 ? 50.029    9.725     -13.477   1     66.81997 ? 190 GLY H N   1 
ATOM   3222 C CA  . GLY B 2 203 ? 51.463    9.506     -13.395   1     58.21044 ? 190 GLY H CA  1 
ATOM   3223 C C   . GLY B 2 203 ? 52.028    9.308     -12.028   1     58.44624 ? 190 GLY H C   1 
ATOM   3224 O O   . GLY B 2 203 ? 53.187    8.975     -11.868   1     60.06349 ? 190 GLY H O   1 
ATOM   3225 N N   . THR B 2 204 ? 51.206    9.51      -11.031   1     55.27886 ? 191 THR H N   1 
ATOM   3226 C CA  . THR B 2 204 ? 51.677    9.382     -9.693    1     57.11949 ? 191 THR H CA  1 
ATOM   3227 C C   . THR B 2 204 ? 51.107    8.166     -9.022    1     62.53712 ? 191 THR H C   1 
ATOM   3228 O O   . THR B 2 204 ? 51.841    7.412     -8.397    1     67.06588 ? 191 THR H O   1 
ATOM   3229 C CB  . THR B 2 204 ? 51.28     10.609    -8.872    1     56.39072 ? 191 THR H CB  1 
ATOM   3230 O OG1 . THR B 2 204 ? 49.856    10.667    -8.738    1     65.34428 ? 191 THR H OG1 1 
ATOM   3231 C CG2 . THR B 2 204 ? 51.763    11.867    -9.56     1     58.56452 ? 191 THR H CG2 1 
ATOM   3232 N N   . GLN B 2 205 ? 49.808    7.954     -9.148    1     58.26343 ? 192 GLN H N   1 
ATOM   3233 C CA  . GLN B 2 205 ? 49.182    6.871     -8.432    1     50.96966 ? 192 GLN H CA  1 
ATOM   3234 C C   . GLN B 2 205 ? 49.356    5.542     -9.134    1     50.00907 ? 192 GLN H C   1 
ATOM   3235 O O   . GLN B 2 205 ? 49.212    5.447     -10.34    1     47.75912 ? 192 GLN H O   1 
ATOM   3236 C CB  . GLN B 2 205 ? 47.701    7.172     -8.158    1     45.96879 ? 192 GLN H CB  1 
ATOM   3237 C CG  . GLN B 2 205 ? 46.941    6.01      -7.542    1     45.98078 ? 192 GLN H CG  1 
ATOM   3238 C CD  . GLN B 2 205 ? 47.345    5.726     -6.109    1     50.95131 ? 192 GLN H CD  1 
ATOM   3239 O OE1 . GLN B 2 205 ? 47.816    4.64      -5.787    1     40.96515 ? 192 GLN H OE1 1 
ATOM   3240 N NE2 . GLN B 2 205 ? 47.153    6.706     -5.238    1     54.03951 ? 192 GLN H NE2 1 
ATOM   3241 N N   . THR B 2 206 ? 49.686    4.526     -8.358    1     42.05163 ? 193 THR H N   1 
ATOM   3242 C CA  . THR B 2 206 ? 49.868    3.199     -8.893    1     40.20505 ? 193 THR H CA  1 
ATOM   3243 C C   . THR B 2 206 ? 48.546    2.456     -8.94     1     32.5115  ? 193 THR H C   1 
ATOM   3244 O O   . THR B 2 206 ? 47.759    2.531     -8.022    1     35.43861 ? 193 THR H O   1 
ATOM   3245 C CB  . THR B 2 206 ? 50.845    2.415     -8.013    1     36.85477 ? 193 THR H CB  1 
ATOM   3246 O OG1 . THR B 2 206 ? 52.099    3.099     -7.969    1     53.81881 ? 193 THR H OG1 1 
ATOM   3247 C CG2 . THR B 2 206 ? 51.065    1.021     -8.569    1     46.26593 ? 193 THR H CG2 1 
ATOM   3248 N N   . TYR B 2 207 ? 48.32     1.738     -10.014   1     36.9612  ? 194 TYR H N   1 
ATOM   3249 C CA  . TYR B 2 207 ? 47.086    0.98      -10.161   1     36.69648 ? 194 TYR H CA  1 
ATOM   3250 C C   . TYR B 2 207 ? 47.331    -0.492    -10.487   1     29.89894 ? 194 TYR H C   1 
ATOM   3251 O O   . TYR B 2 207 ? 47.928    -0.818    -11.497   1     32.00457 ? 194 TYR H O   1 
ATOM   3252 C CB  . TYR B 2 207 ? 46.155    1.651     -11.184   1     30.44405 ? 194 TYR H CB  1 
ATOM   3253 C CG  . TYR B 2 207 ? 45.668    3.007     -10.74    1     35.2612  ? 194 TYR H CG  1 
ATOM   3254 C CD1 . TYR B 2 207 ? 44.827    3.136     -9.65     1     26.74023 ? 194 TYR H CD1 1 
ATOM   3255 C CD2 . TYR B 2 207 ? 46.055    4.157     -11.405   1     33.37582 ? 194 TYR H CD2 1 
ATOM   3256 C CE1 . TYR B 2 207 ? 44.38     4.37      -9.238    1     31.55285 ? 194 TYR H CE1 1 
ATOM   3257 C CE2 . TYR B 2 207 ? 45.61     5.398     -11.003   1     30.21985 ? 194 TYR H CE2 1 
ATOM   3258 C CZ  . TYR B 2 207 ? 44.775    5.498     -9.918    1     37.82231 ? 194 TYR H CZ  1 
ATOM   3259 O OH  . TYR B 2 207 ? 44.335    6.726     -9.504    1     39.25678 ? 194 TYR H OH  1 
ATOM   3260 N N   . ILE B 2 208 ? 46.862    -1.361    -9.605    1     31.21629 ? 195 ILE H N   1 
ATOM   3261 C CA  . ILE B 2 208 ? 47.015    -2.8      -9.797    1     31.3163  ? 195 ILE H CA  1 
ATOM   3262 C C   . ILE B 2 208 ? 45.728    -3.581    -9.507    1     33.21277 ? 195 ILE H C   1 
ATOM   3263 O O   . ILE B 2 208 ? 45.019    -3.276    -8.564    1     30.27653 ? 195 ILE H O   1 
ATOM   3264 C CB  . ILE B 2 208 ? 48.117    -3.38     -8.899    1     38.13734 ? 195 ILE H CB  1 
ATOM   3265 C CG1 . ILE B 2 208 ? 49.431    -2.627    -9.109    1     39.24958 ? 195 ILE H CG1 1 
ATOM   3266 C CG2 . ILE B 2 208 ? 48.311    -4.866    -9.154    1     35.8294  ? 195 ILE H CG2 1 
ATOM   3267 C CD1 . ILE B 2 208 ? 50.389    -2.747    -7.949    1     33.03567 ? 195 ILE H CD1 1 
ATOM   3268 N N   . CYS B 2 209 ? 45.448    -4.581    -10.32    1     32.11918 ? 196 CYS H N   1 
ATOM   3269 C CA  . CYS B 2 209 ? 44.279    -5.425    -10.118   1     34.6669  ? 196 CYS H CA  1 
ATOM   3270 C C   . CYS B 2 209 ? 44.651    -6.743    -9.494    1     28.25406 ? 196 CYS H C   1 
ATOM   3271 O O   . CYS B 2 209 ? 45.614    -7.366    -9.884    1     25.56515 ? 196 CYS H O   1 
ATOM   3272 C CB  . CYS B 2 209 ? 43.513    -5.695    -11.419   1     23.90495 ? 196 CYS H CB  1 
ATOM   3273 S SG  . CYS B 2 209 ? 44.345    -6.616    -12.7     1     33.99458 ? 196 CYS H SG  1 
ATOM   3274 N N   . ASN B 2 210 ? 43.881    -7.142    -8.51     1     26.16642 ? 197 ASN H N   1 
ATOM   3275 C CA  . ASN B 2 210 ? 44.113    -8.404    -7.856    1     31.95273 ? 197 ASN H CA  1 
ATOM   3276 C C   . ASN B 2 210 ? 43.01     -9.387    -8.252    1     24.39259 ? 197 ASN H C   1 
ATOM   3277 O O   . ASN B 2 210 ? 41.878    -9.228    -7.864    1     26.52513 ? 197 ASN H O   1 
ATOM   3278 C CB  . ASN B 2 210 ? 44.173    -8.194    -6.349    1     27.65542 ? 197 ASN H CB  1 
ATOM   3279 C CG  . ASN B 2 210 ? 44.846    -6.9      -5.965    1     36.26071 ? 197 ASN H CG  1 
ATOM   3280 O OD1 . ASN B 2 210 ? 44.218    -6.015    -5.396    1     34.46046 ? 197 ASN H OD1 1 
ATOM   3281 N ND2 . ASN B 2 210 ? 46.123    -6.777    -6.286    1     24.86512 ? 197 ASN H ND2 1 
ATOM   3282 N N   . VAL B 2 211 ? 43.359    -10.381   -9.038    1     24.59969 ? 198 VAL H N   1 
ATOM   3283 C CA  . VAL B 2 211 ? 42.388    -11.339   -9.509    1     27.16469 ? 198 VAL H CA  1 
ATOM   3284 C C   . VAL B 2 211 ? 42.491    -12.682   -8.782    1     30.22833 ? 198 VAL H C   1 
ATOM   3285 O O   . VAL B 2 211 ? 43.486    -13.359   -8.86     1     29.4354  ? 198 VAL H O   1 
ATOM   3286 C CB  . VAL B 2 211 ? 42.482    -11.541   -11.043   1     28.12989 ? 198 VAL H CB  1 
ATOM   3287 C CG1 . VAL B 2 211 ? 41.484    -12.581   -11.51    1     31.43987 ? 198 VAL H CG1 1 
ATOM   3288 C CG2 . VAL B 2 211 ? 42.297    -10.223   -11.772   1     24.19432 ? 198 VAL H CG2 1 
ATOM   3289 N N   . ASN B 2 212 ? 41.437    -13.042   -8.079    1     28.54296 ? 199 ASN H N   1 
ATOM   3290 C CA  . ASN B 2 212 ? 41.417    -14.298   -7.359    1     32.61509 ? 199 ASN H CA  1 
ATOM   3291 C C   . ASN B 2 212 ? 40.503    -15.359   -7.986    1     29.23476 ? 199 ASN H C   1 
ATOM   3292 O O   . ASN B 2 212 ? 39.311    -15.126   -8.122    1     27.708   ? 199 ASN H O   1 
ATOM   3293 C CB  . ASN B 2 212 ? 41.016    -14.042   -5.904    1     31.5117  ? 199 ASN H CB  1 
ATOM   3294 C CG  . ASN B 2 212 ? 41.156    -15.276   -5.033    1     40.71303 ? 199 ASN H CG  1 
ATOM   3295 O OD1 . ASN B 2 212 ? 41.778    -16.258   -5.423    1     43.31715 ? 199 ASN H OD1 1 
ATOM   3296 N ND2 . ASN B 2 212 ? 40.582    -15.227   -3.847    1     39.147   ? 199 ASN H ND2 1 
ATOM   3297 N N   . HIS B 2 213 ? 41.064    -16.494   -8.388    1     25.59648 ? 200 HIS H N   1 
ATOM   3298 C CA  . HIS B 2 213 ? 40.283    -17.602   -8.926    1     25.5111  ? 200 HIS H CA  1 
ATOM   3299 C C   . HIS B 2 213 ? 40.456    -18.765   -7.974    1     29.02755 ? 200 HIS H C   1 
ATOM   3300 O O   . HIS B 2 213 ? 41.329    -19.592   -8.158    1     28.21951 ? 200 HIS H O   1 
ATOM   3301 C CB  . HIS B 2 213 ? 40.694    -17.955   -10.348   1     21.29697 ? 200 HIS H CB  1 
ATOM   3302 C CG  . HIS B 2 213 ? 39.866    -19.02    -10.988   1     24.21482 ? 200 HIS H CG  1 
ATOM   3303 N ND1 . HIS B 2 213 ? 40.392    -20.229   -11.38    1     23.10886 ? 200 HIS H ND1 1 
ATOM   3304 C CD2 . HIS B 2 213 ? 38.558    -19.05    -11.332   1     22.64797 ? 200 HIS H CD2 1 
ATOM   3305 C CE1 . HIS B 2 213 ? 39.442    -20.963   -11.925   1     23.26088 ? 200 HIS H CE1 1 
ATOM   3306 N NE2 . HIS B 2 213 ? 38.321    -20.271   -11.909   1     21.61192 ? 200 HIS H NE2 1 
ATOM   3307 N N   . LYS B 2 214 ? 39.622    -18.81    -6.951    1     27.43139 ? 201 LYS H N   1 
ATOM   3308 C CA  . LYS B 2 214 ? 39.711    -19.833   -5.928    1     25.73863 ? 201 LYS H CA  1 
ATOM   3309 C C   . LYS B 2 214 ? 39.603    -21.274   -6.424    1     30.05765 ? 201 LYS H C   1 
ATOM   3310 O O   . LYS B 2 214 ? 40.321    -22.119   -5.947    1     34.93758 ? 201 LYS H O   1 
ATOM   3311 C CB  . LYS B 2 214 ? 38.646    -19.562   -4.876    1     24.55862 ? 201 LYS H CB  1 
ATOM   3312 C CG  . LYS B 2 214 ? 38.875    -18.293   -4.079    1     42.28049 ? 201 LYS H CG  1 
ATOM   3313 C CD  . LYS B 2 214 ? 37.788    -18.066   -3.048    1     34.1169  ? 201 LYS H CD  1 
ATOM   3314 C CE  . LYS B 2 214 ? 38.088    -16.841   -2.208    1     34.15253 ? 201 LYS H CE  1 
ATOM   3315 N NZ  . LYS B 2 214 ? 36.88     -16.326   -1.515    1     54.27796 ? 201 LYS H NZ  1 
ATOM   3316 N N   . PRO B 2 215 ? 38.714    -21.536   -7.394    1     27.1769  ? 202 PRO H N   1 
ATOM   3317 C CA  . PRO B 2 215 ? 38.605    -22.886   -7.934    1     25.24354 ? 202 PRO H CA  1 
ATOM   3318 C C   . PRO B 2 215 ? 39.928    -23.447   -8.44     1     28.24857 ? 202 PRO H C   1 
ATOM   3319 O O   . PRO B 2 215 ? 40.005    -24.642   -8.578    1     38.61497 ? 202 PRO H O   1 
ATOM   3320 C CB  . PRO B 2 215 ? 37.607    -22.714   -9.07     1     24.21987 ? 202 PRO H CB  1 
ATOM   3321 C CG  . PRO B 2 215 ? 36.733    -21.606   -8.617    1     30.76814 ? 202 PRO H CG  1 
ATOM   3322 C CD  . PRO B 2 215 ? 37.654    -20.656   -7.913    1     23.70708 ? 202 PRO H CD  1 
ATOM   3323 N N   . SER B 2 216 ? 40.919    -22.617   -8.723    1     28.83018 ? 203 SER H N   1 
ATOM   3324 C CA  . SER B 2 216 ? 42.262    -23.069   -9.135    1     35.81828 ? 203 SER H CA  1 
ATOM   3325 C C   . SER B 2 216 ? 43.34     -22.632   -8.16     1     30.41325 ? 203 SER H C   1 
ATOM   3326 O O   . SER B 2 216 ? 44.502    -22.744   -8.452    1     38.1965  ? 203 SER H O   1 
ATOM   3327 C CB  . SER B 2 216 ? 42.607    -22.516   -10.511   1     33.89111 ? 203 SER H CB  1 
ATOM   3328 O OG  . SER B 2 216 ? 42.776    -21.118   -10.477   1     38.63308 ? 203 SER H OG  1 
ATOM   3329 N N   . ASN B 2 217 ? 42.947    -22.103   -7.022    1     31.87143 ? 204 ASN H N   1 
ATOM   3330 C CA  . ASN B 2 217 ? 43.893    -21.567   -6.043    1     42.97376 ? 204 ASN H CA  1 
ATOM   3331 C C   . ASN B 2 217 ? 44.846    -20.589   -6.721    1     41.12588 ? 204 ASN H C   1 
ATOM   3332 O O   . ASN B 2 217 ? 46.027    -20.571   -6.425    1     39.16482 ? 204 ASN H O   1 
ATOM   3333 C CB  . ASN B 2 217 ? 44.649    -22.677   -5.296    1     43.92425 ? 204 ASN H CB  1 
ATOM   3334 C CG  . ASN B 2 217 ? 45.002    -22.289   -3.868    1     51.08613 ? 204 ASN H CG  1 
ATOM   3335 O OD1 . ASN B 2 217 ? 44.261    -21.57    -3.208    1     49.94918 ? 204 ASN H OD1 1 
ATOM   3336 N ND2 . ASN B 2 217 ? 46.133    -22.783   -3.381    1     47.76384 ? 204 ASN H ND2 1 
ATOM   3337 N N   . THR B 2 218 ? 44.32     -19.787   -7.63     1     38.35103 ? 205 THR H N   1 
ATOM   3338 C CA  . THR B 2 218 ? 45.144    -18.834   -8.369    1     39.15118 ? 205 THR H CA  1 
ATOM   3339 C C   . THR B 2 218 ? 44.885    -17.406   -7.971    1     34.25875 ? 205 THR H C   1 
ATOM   3340 O O   . THR B 2 218 ? 43.749    -16.981   -7.944    1     30.24954 ? 205 THR H O   1 
ATOM   3341 C CB  . THR B 2 218 ? 44.934    -18.951   -9.89     1     25.09691 ? 205 THR H CB  1 
ATOM   3342 O OG1 . THR B 2 218 ? 45.27     -20.271   -10.316   1     43.68699 ? 205 THR H OG1 1 
ATOM   3343 C CG2 . THR B 2 218 ? 45.793    -17.958   -10.621   1     44.81763 ? 205 THR H CG2 1 
ATOM   3344 N N   . LYS B 2 219 ? 45.923    -16.683   -7.623    1     28.08848 ? 206 LYS H N   1 
ATOM   3345 C CA  . LYS B 2 219 ? 45.797    -15.275   -7.335    1     27.83042 ? 206 LYS H CA  1 
ATOM   3346 C C   . LYS B 2 219 ? 46.794    -14.551   -8.228    1     44.35311 ? 206 LYS H C   1 
ATOM   3347 O O   . LYS B 2 219 ? 47.947    -14.944   -8.301    1     36.97376 ? 206 LYS H O   1 
ATOM   3348 C CB  . LYS B 2 219 ? 46.044    -14.988   -5.886    1     36.07907 ? 206 LYS H CB  1 
ATOM   3349 C CG  . LYS B 2 219 ? 45.706    -13.567   -5.461    1     50.81913 ? 206 LYS H CG  1 
ATOM   3350 C CD  . LYS B 2 219 ? 44.257    -13.449   -5.023    1     53.60789 ? 206 LYS H CD  1 
ATOM   3351 C CE  . LYS B 2 219 ? 43.819    -12.001   -4.871    1     44.72887 ? 206 LYS H CE  1 
ATOM   3352 N NZ  . LYS B 2 219 ? 44.409    -11.317   -3.695    1     47.62599 ? 206 LYS H NZ  1 
ATOM   3353 N N   . VAL B 2 220 ? 46.35     -13.532   -8.936    1     41.03655 ? 207 VAL H N   1 
ATOM   3354 C CA  . VAL B 2 220 ? 47.191    -12.817   -9.875    1     35.0634  ? 207 VAL H CA  1 
ATOM   3355 C C   . VAL B 2 220 ? 47.02     -11.315   -9.799    1     39.29421 ? 207 VAL H C   1 
ATOM   3356 O O   . VAL B 2 220 ? 45.914    -10.813   -9.804    1     35.43882 ? 207 VAL H O   1 
ATOM   3357 C CB  . VAL B 2 220 ? 46.929    -13.279   -11.303   1     33.46557 ? 207 VAL H CB  1 
ATOM   3358 C CG1 . VAL B 2 220 ? 47.539    -12.31    -12.298   1     44.11049 ? 207 VAL H CG1 1 
ATOM   3359 C CG2 . VAL B 2 220 ? 47.463    -14.679   -11.515   1     39.36653 ? 207 VAL H CG2 1 
ATOM   3360 N N   . ASP B 2 221 ? 48.133    -10.613   -9.712    1     34.94409 ? 208 ASP H N   1 
ATOM   3361 C CA  . ASP B 2 221 ? 48.112    -9.17     -9.652    1     38.62261 ? 208 ASP H CA  1 
ATOM   3362 C C   . ASP B 2 221 ? 48.66     -8.599    -10.94    1     37.73477 ? 208 ASP H C   1 
ATOM   3363 O O   . ASP B 2 221 ? 49.679    -9.05     -11.405   1     44.92827 ? 208 ASP H O   1 
ATOM   3364 C CB  . ASP B 2 221 ? 48.942    -8.711    -8.472    1     33.77527 ? 208 ASP H CB  1 
ATOM   3365 C CG  . ASP B 2 221 ? 48.374    -9.149    -7.145    1     40.43698 ? 208 ASP H CG  1 
ATOM   3366 O OD1 . ASP B 2 221 ? 47.145    -9.175    -6.985    1     44.17539 ? 208 ASP H OD1 1 
ATOM   3367 O OD2 . ASP B 2 221 ? 49.169    -9.469    -6.252    1     48.32273 ? 208 ASP H OD2 1 
ATOM   3368 N N   . LYS B 2 222 ? 47.981    -7.63     -11.537   1     39.71642 ? 209 LYS H N   1 
ATOM   3369 C CA  . LYS B 2 222 ? 48.489    -6.96     -12.729   1     34.46651 ? 209 LYS H CA  1 
ATOM   3370 C C   . LYS B 2 222 ? 48.527    -5.456    -12.557   1     43.09325 ? 209 LYS H C   1 
ATOM   3371 O O   . LYS B 2 222 ? 47.534    -4.85     -12.195   1     36.31673 ? 209 LYS H O   1 
ATOM   3372 C CB  . LYS B 2 222 ? 47.644    -7.264    -13.948   1     33.76469 ? 209 LYS H CB  1 
ATOM   3373 C CG  . LYS B 2 222 ? 47.957    -6.41     -15.158   1     44.21941 ? 209 LYS H CG  1 
ATOM   3374 C CD  . LYS B 2 222 ? 49.249    -6.842    -15.824   1     45.65551 ? 209 LYS H CD  1 
ATOM   3375 C CE  . LYS B 2 222 ? 49.114    -8.226    -16.423   1     42.61518 ? 209 LYS H CE  1 
ATOM   3376 N NZ  . LYS B 2 222 ? 50.367    -8.648    -17.099   1     59.66456 ? 209 LYS H NZ  1 
ATOM   3377 N N   . ARG B 2 223 ? 49.676    -4.861    -12.814   1     42.9758  ? 210 ARG H N   1 
ATOM   3378 C CA  . ARG B 2 223 ? 49.815    -3.43     -12.738   1     37.9572  ? 210 ARG H CA  1 
ATOM   3379 C C   . ARG B 2 223 ? 49.423    -2.833    -14.071   1     34.87515 ? 210 ARG H C   1 
ATOM   3380 O O   . ARG B 2 223 ? 49.853    -3.293    -15.109   1     29.01607 ? 210 ARG H O   1 
ATOM   3381 C CB  . ARG B 2 223 ? 51.238    -3.053    -12.372   1     43.6111  ? 210 ARG H CB  1 
ATOM   3382 C CG  . ARG B 2 223 ? 51.485    -1.572    -12.157   1     51.04026 ? 210 ARG H CG  1 
ATOM   3383 C CD  . ARG B 2 223 ? 52.971    -1.287    -12.246   1     57.21139 ? 210 ARG H CD  1 
ATOM   3384 N NE  . ARG B 2 223 ? 53.44     -0.288    -11.292   1     71.89763 ? 210 ARG H NE  1 
ATOM   3385 C CZ  . ARG B 2 223 ? 53.492    1.018     -11.534   1     75.60745 ? 210 ARG H CZ  1 
ATOM   3386 N NH1 . ARG B 2 223 ? 53.081    1.496     -12.697   1     72.40219 ? 210 ARG H NH1 1 
ATOM   3387 N NH2 . ARG B 2 223 ? 53.949    1.848     -10.609   1     68.0288  ? 210 ARG H NH2 1 
ATOM   3388 N N   . VAL B 2 224 ? 48.586    -1.818    -14.015   1     36.27789 ? 211 VAL H N   1 
ATOM   3389 C CA  . VAL B 2 224 ? 48.11     -1.171    -15.22    1     40.87365 ? 211 VAL H CA  1 
ATOM   3390 C C   . VAL B 2 224 ? 48.852    0.132     -15.394   1     43.61533 ? 211 VAL H C   1 
ATOM   3391 O O   . VAL B 2 224 ? 48.63     1.085     -14.678   1     39.36768 ? 211 VAL H O   1 
ATOM   3392 C CB  . VAL B 2 224 ? 46.595    -0.92     -15.165   1     35.15213 ? 211 VAL H CB  1 
ATOM   3393 C CG1 . VAL B 2 224 ? 46.078    -0.508    -16.53    1     34.14583 ? 211 VAL H CG1 1 
ATOM   3394 C CG2 . VAL B 2 224 ? 45.875    -2.164    -14.674   1     36.3177  ? 211 VAL H CG2 1 
ATOM   3395 N N   . GLU B 2 225 ? 49.73     0.163     -16.37    1     46.10356 ? 212 GLU H N   1 
ATOM   3396 C CA  . GLU B 2 225 ? 50.551    1.339     -16.564   1     52.99269 ? 212 GLU H CA  1 
ATOM   3397 C C   . GLU B 2 225 ? 50.045    2.165     -17.696   1     54.42776 ? 212 GLU H C   1 
ATOM   3398 O O   . GLU B 2 225 ? 49.65     1.645     -18.732   1     48.29034 ? 212 GLU H O   1 
ATOM   3399 C CB  . GLU B 2 225 ? 52.01     0.943     -16.788   1     52.73853 ? 212 GLU H CB  1 
ATOM   3400 C CG  . GLU B 2 225 ? 52.698    0.507     -15.511   1     58.71148 ? 212 GLU H CG  1 
ATOM   3401 C CD  . GLU B 2 225 ? 53.98     -0.255    -15.75    1     65.26332 ? 212 GLU H CD  1 
ATOM   3402 O OE1 . GLU B 2 225 ? 54.491    -0.235    -16.886   1     66.82733 ? 212 GLU H OE1 1 
ATOM   3403 O OE2 . GLU B 2 225 ? 54.474    -0.88     -14.794   1     60.17163 ? 212 GLU H OE2 1 
ATOM   3404 N N   . PRO B 2 226 ? 50.057    3.472     -17.496   1     56.34387 ? 213 PRO H N   1 
ATOM   3405 C CA  . PRO B 2 226 ? 49.555    4.375     -18.517   1     53.0714  ? 213 PRO H CA  1 
ATOM   3406 C C   . PRO B 2 226 ? 50.325    4.168     -19.788   1     50.04357 ? 213 PRO H C   1 
ATOM   3407 O O   . PRO B 2 226 ? 51.528    4.004     -19.729   1     57.72076 ? 213 PRO H O   1 
ATOM   3408 C CB  . PRO B 2 226 ? 49.805    5.755     -17.903   1     42.98963 ? 213 PRO H CB  1 
ATOM   3409 C CG  . PRO B 2 226 ? 49.889    5.526     -16.443   1     46.82783 ? 213 PRO H CG  1 
ATOM   3410 C CD  . PRO B 2 226 ? 50.527    4.185     -16.3     1     51.19218 ? 213 PRO H CD  1 
ATOM   3411 N N   . LYS B 2 227 ? 49.641    4.176     -20.916   1     51.39176 ? 214 LYS H N   1 
ATOM   3412 C CA  . LYS B 2 227 ? 50.281    3.909     -22.175   1     65.72479 ? 214 LYS H CA  1 
ATOM   3413 C C   . LYS B 2 227 ? 49.251    3.758     -23.267   1     65.44008 ? 214 LYS H C   1 
ATOM   3414 O O   . LYS B 2 227 ? 49.052    2.674     -23.801   1     70.95987 ? 214 LYS H O   1 
ATOM   3415 C CB  . LYS B 2 227 ? 51.1      2.63      -22.098   1     73.18211 ? 214 LYS H CB  1 
ATOM   3416 C CG  . LYS B 2 227 ? 52.138    2.517     -23.202   1     84.63664 ? 214 LYS H CG  1 
ATOM   3417 C CD  . LYS B 2 227 ? 53.234    3.554     -23.021   1     75.54415 ? 214 LYS H CD  1 
ATOM   3418 C CE  . LYS B 2 227 ? 53.772    4.022     -24.36    1     74.01613 ? 214 LYS H CE  1 
ATOM   3419 N NZ  . LYS B 2 227 ? 52.733    4.775     -25.112   1     77.49609 ? 214 LYS H NZ  1 
ATOM   3420 N N   . ASP C 3 1   ? 5.98300   -27.95700 -0.50700  1.000 38.95548 ? 1   ASP L N   1 
ATOM   3421 C CA  . ASP C 3 1   ? 4.64500   -28.17500 -0.96600  1.000 35.29136 ? 1   ASP L CA  1 
ATOM   3422 C C   . ASP C 3 1   ? 3.84400   -26.89700 -0.79300  1.000 30.90204 ? 1   ASP L C   1 
ATOM   3423 O O   . ASP C 3 1   ? 2.95200   -26.65400 -1.56500  1.000 41.63969 ? 1   ASP L O   1 
ATOM   3424 C CB  . ASP C 3 1   ? 4.03400   -29.37900 -0.26900  1.000 28.45493 ? 1   ASP L CB  1 
ATOM   3425 C CG  . ASP C 3 1   ? 4.79500   -30.64800 -0.55300  1.000 69.97760 ? 1   ASP L CG  1 
ATOM   3426 O OD1 . ASP C 3 1   ? 5.99500   -30.70400 -0.20700  1.000 71.31914 ? 1   ASP L OD1 1 
ATOM   3427 O OD2 . ASP C 3 1   ? 4.20600   -31.58300 -1.13800  1.000 70.03138 ? 1   ASP L OD2 1 
ATOM   3428 N N   . ILE C 3 2   ? 4.13400   -26.09000 0.21600   1.000 30.07811 ? 2   ILE L N   1 
ATOM   3429 C CA  . ILE C 3 2   ? 3.48700   -24.78600 0.32000   1.000 26.76857 ? 2   ILE L CA  1 
ATOM   3430 C C   . ILE C 3 2   ? 4.14100   -23.86400 -0.70400  1.000 26.83433 ? 2   ILE L C   1 
ATOM   3431 O O   . ILE C 3 2   ? 5.31600   -23.51300 -0.57700  1.000 23.76642 ? 2   ILE L O   1 
ATOM   3432 C CB  . ILE C 3 2   ? 3.58900   -24.20600 1.73400   1.000 25.62624 ? 2   ILE L CB  1 
ATOM   3433 C CG1 . ILE C 3 2   ? 2.80000   -25.06200 2.72600   1.000 29.42446 ? 2   ILE L CG1 1 
ATOM   3434 C CG2 . ILE C 3 2   ? 3.07300   -22.77200 1.75600   1.000 17.47005 ? 2   ILE L CG2 1 
ATOM   3435 C CD1 . ILE C 3 2   ? 2.70300   -24.45500 4.10800   1.000 27.26394 ? 2   ILE L CD1 1 
ATOM   3436 N N   . VAL C 3 3   ? 3.38500   -23.47800 -1.72300  1.000 23.17094 ? 3   VAL L N   1 
ATOM   3437 C CA  . VAL C 3 3   ? 3.89000   -22.61400 -2.78200  1.000 25.25840 ? 3   VAL L CA  1 
ATOM   3438 C C   . VAL C 3 3   ? 3.76700   -21.16500 -2.33200  1.000 20.38392 ? 3   VAL L C   1 
ATOM   3439 O O   . VAL C 3 3   ? 2.69400   -20.72400 -1.90600  1.000 25.21556 ? 3   VAL L O   1 
ATOM   3440 C CB  . VAL C 3 3   ? 3.13000   -22.85100 -4.09800  1.000 26.37336 ? 3   VAL L CB  1 
ATOM   3441 C CG1 . VAL C 3 3   ? 3.61700   -21.88900 -5.17600  1.000 26.99127 ? 3   VAL L CG1 1 
ATOM   3442 C CG2 . VAL C 3 3   ? 3.29100   -24.29700 -4.54700  1.000 25.71513 ? 3   VAL L CG2 1 
ATOM   3443 N N   . MET C 3 4   ? 4.87000   -20.42500 -2.42300  1.000 19.71013 ? 4   MET L N   1 
ATOM   3444 C CA  . MET C 3 4   ? 4.91500   -19.01300 -2.06200  1.000 21.28809 ? 4   MET L CA  1 
ATOM   3445 C C   . MET C 3 4   ? 4.92700   -18.20000 -3.35200  1.000 22.49543 ? 4   MET L C   1 
ATOM   3446 O O   . MET C 3 4   ? 5.88900   -18.26700 -4.12400  1.000 24.71361 ? 4   MET L O   1 
ATOM   3447 C CB  . MET C 3 4   ? 6.14900   -18.71200 -1.21200  1.000 16.90568 ? 4   MET L CB  1 
ATOM   3448 C CG  . MET C 3 4   ? 6.23100   -19.46500 0.10900   1.000 16.42274 ? 4   MET L CG  1 
ATOM   3449 S SD  . MET C 3 4   ? 4.69600   -19.45100 1.04800   1.000 21.81882 ? 4   MET L SD  1 
ATOM   3450 C CE  . MET C 3 4   ? 4.85600   -17.89600 1.91800   1.000 21.27690 ? 4   MET L CE  1 
ATOM   3451 N N   . THR C 3 5   ? 3.86400   -17.43600 -3.58700  1.000 21.36855 ? 5   THR L N   1 
ATOM   3452 C CA  . THR C 3 5   ? 3.72400   -16.64400 -4.80400  1.000 24.40599 ? 5   THR L CA  1 
ATOM   3453 C C   . THR C 3 5   ? 3.83700   -15.16600 -4.45700  1.000 21.02375 ? 5   THR L C   1 
ATOM   3454 O O   . THR C 3 5   ? 3.04000   -14.64700 -3.66800  1.000 25.97696 ? 5   THR L O   1 
ATOM   3455 C CB  . THR C 3 5   ? 2.39300   -16.93200 -5.49800  1.000 22.84349 ? 5   THR L CB  1 
ATOM   3456 O OG1 . THR C 3 5   ? 2.28500   -18.33700 -5.75900  1.000 20.82905 ? 5   THR L OG1 1 
ATOM   3457 C CG2 . THR C 3 5   ? 2.31000   -16.17400 -6.81300  1.000 15.78342 ? 5   THR L CG2 1 
ATOM   3458 N N   . GLN C 3 6   ? 4.82100   -14.49600 -5.04900  1.000 21.97690 ? 6   GLN L N   1 
ATOM   3459 C CA  . GLN C 3 6   ? 5.04900   -13.07600 -4.83500  1.000 21.63583 ? 6   GLN L CA  1 
ATOM   3460 C C   . GLN C 3 6   ? 4.51000   -12.27300 -6.01200  1.000 28.06116 ? 6   GLN L C   1 
ATOM   3461 O O   . GLN C 3 6   ? 4.49200   -12.74200 -7.15200  1.000 23.62320 ? 6   GLN L O   1 
ATOM   3462 C CB  . GLN C 3 6   ? 6.54000   -12.78400 -4.64600  1.000 20.57746 ? 6   GLN L CB  1 
ATOM   3463 C CG  . GLN C 3 6   ? 7.06100   -13.09700 -3.25400  1.000 22.52389 ? 6   GLN L CG  1 
ATOM   3464 C CD  . GLN C 3 6   ? 8.54800   -12.83200 -3.11000  1.000 21.70112 ? 6   GLN L CD  1 
ATOM   3465 O OE1 . GLN C 3 6   ? 9.33000   -13.74600 -2.84800  1.000 20.18798 ? 6   GLN L OE1 1 
ATOM   3466 N NE2 . GLN C 3 6   ? 8.94600   -11.57500 -3.27700  1.000 14.39047 ? 6   GLN L NE2 1 
ATOM   3467 N N   . SER C 3 7   ? 4.01900   -11.07700 -5.74900  1.000 19.90580 ? 7   SER L N   1 
ATOM   3468 C CA  . SER C 3 7   ? 3.57400   -10.16800 -6.79300  1.000 25.57256 ? 7   SER L CA  1 
ATOM   3469 C C   . SER C 3 7   ? 3.94800   -8.73300  -6.40300  1.000 19.69431 ? 7   SER L C   1 
ATOM   3470 O O   . SER C 3 7   ? 3.67700   -8.31100  -5.29900  1.000 20.91100 ? 7   SER L O   1 
ATOM   3471 C CB  . SER C 3 7   ? 2.06800   -10.26400 -7.07600  1.000 25.32533 ? 7   SER L CB  1 
ATOM   3472 O OG  . SER C 3 7   ? 1.70600   -9.48800  -8.19000  1.000 39.70682 ? 7   SER L OG  1 
ATOM   3473 N N   . PRO C 3 8   ? 4.58800   -8.00400  -7.33100  1.000 19.63162 ? 8   PRO L N   1 
ATOM   3474 C CA  . PRO C 3 8   ? 4.98000   -8.44200  -8.67600  1.000 18.76653 ? 8   PRO L CA  1 
ATOM   3475 C C   . PRO C 3 8   ? 6.29700   -9.20700  -8.65000  1.000 25.15012 ? 8   PRO L C   1 
ATOM   3476 O O   . PRO C 3 8   ? 6.89100   -9.38800  -7.59000  1.000 25.15690 ? 8   PRO L O   1 
ATOM   3477 C CB  . PRO C 3 8   ? 5.09600   -7.11900  -9.43700  1.000 19.12828 ? 8   PRO L CB  1 
ATOM   3478 C CG  . PRO C 3 8   ? 5.59600   -6.15700  -8.39100  1.000 16.98071 ? 8   PRO L CG  1 
ATOM   3479 C CD  . PRO C 3 8   ? 4.94300   -6.59200  -7.09400  1.000 19.88950 ? 8   PRO L CD  1 
ATOM   3480 N N   . SER C 3 9   ? 6.77600   -9.67700  -9.80200  1.000 22.16565 ? 9   SER L N   1 
ATOM   3481 C CA  . SER C 3 9   ? 8.08400   -10.31400 -9.86100  1.000 21.02054 ? 9   SER L CA  1 
ATOM   3482 C C   . SER C 3 9   ? 9.21200   -9.30300  -10.00300 1.000 21.74921 ? 9   SER L C   1 
ATOM   3483 O O   . SER C 3 9   ? 10.36400  -9.62800  -9.69200  1.000 24.33917 ? 9   SER L O   1 
ATOM   3484 C CB  . SER C 3 9   ? 8.13200   -11.31400 -11.01900 1.000 22.88599 ? 9   SER L CB  1 
ATOM   3485 O OG  . SER C 3 9   ? 7.43600   -12.50400 -10.68900 1.000 30.28108 ? 9   SER L OG  1 
ATOM   3486 N N   . SER C 3 10  ? 8.90500   -8.09100  -10.45700 1.000 22.51339 ? 10  SER L N   1 
ATOM   3487 C CA  . SER C 3 10  ? 9.88600   -7.02200  -10.57200 1.000 23.97393 ? 10  SER L CA  1 
ATOM   3488 C C   . SER C 3 10  ? 9.14200   -5.70000  -10.67100 1.000 24.61436 ? 10  SER L C   1 
ATOM   3489 O O   . SER C 3 10  ? 8.05800   -5.62800  -11.25600 1.000 26.58318 ? 10  SER L O   1 
ATOM   3490 C CB  . SER C 3 10  ? 10.79600  -7.21500  -11.79000 1.000 24.76221 ? 10  SER L CB  1 
ATOM   3491 O OG  . SER C 3 10  ? 10.07500  -7.03100  -12.99600 1.000 30.57607 ? 10  SER L OG  1 
ATOM   3492 N N   . LEU C 3 11  ? 9.73000   -4.65700  -10.09000 1.000 24.98219 ? 11  LEU L N   1 
ATOM   3493 C CA  . LEU C 3 11  ? 9.13100   -3.33300  -10.15500 1.000 24.69016 ? 11  LEU L CA  1 
ATOM   3494 C C   . LEU C 3 11  ? 10.22800  -2.28200  -10.19900 1.000 26.27536 ? 11  LEU L C   1 
ATOM   3495 O O   . LEU C 3 11  ? 11.37500  -2.53100  -9.82000  1.000 21.84185 ? 11  LEU L O   1 
ATOM   3496 C CB  . LEU C 3 11  ? 8.18600   -3.07200  -8.97200  1.000 25.67485 ? 11  LEU L CB  1 
ATOM   3497 C CG  . LEU C 3 11  ? 8.76000   -3.02800  -7.55200  1.000 25.57237 ? 11  LEU L CG  1 
ATOM   3498 C CD1 . LEU C 3 11  ? 9.13500   -1.60900  -7.13800  1.000 24.37624 ? 11  LEU L CD1 1 
ATOM   3499 C CD2 . LEU C 3 11  ? 7.76100   -3.61900  -6.57100  1.000 24.08190 ? 11  LEU L CD2 1 
ATOM   3500 N N   . SER C 3 12  ? 9.88000   -1.12000  -10.69700 1.000 28.33609 ? 12  SER L N   1 
ATOM   3501 C CA  A SER C 3 12  ? 10.79600  0.01200   -10.73800 0.446 29.46232 ? 12  SER L CA  1 
ATOM   3502 C CA  B SER C 3 12  ? 10.79700  0.01800   -10.73300 0.554 29.47296 ? 12  SER L CA  1 
ATOM   3503 C C   . SER C 3 12  ? 10.06500  1.25300   -10.11400 1.000 25.81286 ? 12  SER L C   1 
ATOM   3504 O O   . SER C 3 12  ? 8.89200   1.57400   -10.39800 1.000 27.41889 ? 12  SER L O   1 
ATOM   3505 C CB  A SER C 3 12  ? 11.24800  0.29300   -12.15900 0.446 30.17918 ? 12  SER L CB  1 
ATOM   3506 C CB  B SER C 3 12  ? 11.25600  0.33600   -12.14400 0.554 30.16060 ? 12  SER L CB  1 
ATOM   3507 O OG  A SER C 3 12  ? 12.38900  1.12400   -12.17900 0.446 31.86561 ? 12  SER L OG  1 
ATOM   3508 O OG  B SER C 3 12  ? 11.85900  -0.78900  -12.74900 0.554 34.81685 ? 12  SER L OG  1 
ATOM   3509 N N   . ALA C 3 13  ? 10.74600  1.93200   -9.21300  1.000 22.68713 ? 13  ALA L N   1 
ATOM   3510 C CA  . ALA C 3 13  ? 10.15800  3.07200   -8.52600  1.000 27.78419 ? 13  ALA L CA  1 
ATOM   3511 C C   . ALA C 3 13  ? 11.23200  4.11700   -8.26800  1.000 21.63608 ? 13  ALA L C   1 
ATOM   3512 O O   . ALA C 3 13  ? 12.42900  3.81900   -8.25000  1.000 21.37256 ? 13  ALA L O   1 
ATOM   3513 C CB  . ALA C 3 13  ? 9.48500   2.65300   -7.21300  1.000 18.54956 ? 13  ALA L CB  1 
ATOM   3514 N N   . SER C 3 14  ? 10.78300  5.35100   -8.06400  1.000 19.33547 ? 14  SER L N   1 
ATOM   3515 C CA  . SER C 3 14  ? 11.67500  6.48000   -7.85200  1.000 21.75409 ? 14  SER L CA  1 
ATOM   3516 C C   . SER C 3 14  ? 12.07000  6.59100   -6.38200  1.000 20.01201 ? 14  SER L C   1 
ATOM   3517 O O   . SER C 3 14  ? 11.41800  6.04000   -5.49200  1.000 20.41120 ? 14  SER L O   1 
ATOM   3518 C CB  . SER C 3 14  ? 11.01400  7.78200   -8.31300  1.000 26.86706 ? 14  SER L CB  1 
ATOM   3519 O OG  . SER C 3 14  ? 10.64300  7.71700   -9.67900  1.000 27.35539 ? 14  SER L OG  1 
ATOM   3520 N N   . ILE C 3 15  ? 13.16400  7.31700   -6.14200  1.000 22.31153 ? 15  ILE L N   1 
ATOM   3521 C CA  . ILE C 3 15  ? 13.60700  7.57600   -4.77800  1.000 23.52379 ? 15  ILE L CA  1 
ATOM   3522 C C   . ILE C 3 15  ? 12.52100  8.33900   -4.03400  1.000 23.28059 ? 15  ILE L C   1 
ATOM   3523 O O   . ILE C 3 15  ? 11.99200  9.34300   -4.52700  1.000 26.71029 ? 15  ILE L O   1 
ATOM   3524 C CB  . ILE C 3 15  ? 14.93400  8.35000   -4.78700  1.000 22.21529 ? 15  ILE L CB  1 
ATOM   3525 C CG1 . ILE C 3 15  ? 16.04100  7.50600   -5.41900  1.000 21.17565 ? 15  ILE L CG1 1 
ATOM   3526 C CG2 . ILE C 3 15  ? 15.32100  8.76900   -3.37700  1.000 24.60397 ? 15  ILE L CG2 1 
ATOM   3527 C CD1 . ILE C 3 15  ? 17.27600  8.30200   -5.78800  1.000 25.38624 ? 15  ILE L CD1 1 
ATOM   3528 N N   . GLY C 3 16  ? 12.17800  7.86000   -2.83900  1.000 25.95025 ? 16  GLY L N   1 
ATOM   3529 C CA  . GLY C 3 16  ? 11.11700  8.44500   -2.05300  1.000 22.51559 ? 16  GLY L CA  1 
ATOM   3530 C C   . GLY C 3 16  ? 9.75100   7.83000   -2.26500  1.000 21.94170 ? 16  GLY L C   1 
ATOM   3531 O O   . GLY C 3 16  ? 8.83700   8.10800   -1.47900  1.000 26.54209 ? 16  GLY L O   1 
ATOM   3532 N N   . ASP C 3 17  ? 9.58100   7.00800   -3.29800  1.000 22.33876 ? 17  ASP L N   1 
ATOM   3533 C CA  . ASP C 3 17  ? 8.30400   6.35700   -3.54000  1.000 24.09088 ? 17  ASP L CA  1 
ATOM   3534 C C   . ASP C 3 17  ? 7.99200   5.34600   -2.44000  1.000 23.11689 ? 17  ASP L C   1 
ATOM   3535 O O   . ASP C 3 17  ? 8.86600   4.90800   -1.68700  1.000 27.80015 ? 17  ASP L O   1 
ATOM   3536 C CB  . ASP C 3 17  ? 8.30600   5.64500   -4.89500  1.000 26.09153 ? 17  ASP L CB  1 
ATOM   3537 C CG  . ASP C 3 17  ? 7.98500   6.57600   -6.04700  1.000 32.39170 ? 17  ASP L CG  1 
ATOM   3538 O OD1 . ASP C 3 17  ? 7.87400   7.79700   -5.81500  1.000 27.37157 ? 17  ASP L OD1 1 
ATOM   3539 O OD2 . ASP C 3 17  ? 7.84500   6.08100   -7.18600  1.000 32.58507 ? 17  ASP L OD2 1 
ATOM   3540 N N   . ARG C 3 18  ? 6.71900   4.97700   -2.35900  1.000 24.71758 ? 18  ARG L N   1 
ATOM   3541 C CA  . ARG C 3 18  ? 6.26300   3.90800   -1.48300  1.000 28.94740 ? 18  ARG L CA  1 
ATOM   3542 C C   . ARG C 3 18  ? 6.11700   2.63300   -2.30200  1.000 27.60436 ? 18  ARG L C   1 
ATOM   3543 O O   . ARG C 3 18  ? 5.42700   2.62500   -3.32800  1.000 35.40276 ? 18  ARG L O   1 
ATOM   3544 C CB  . ARG C 3 18  ? 4.93700   4.27400   -0.81600  1.000 27.87817 ? 18  ARG L CB  1 
ATOM   3545 C CG  . ARG C 3 18  ? 4.39500   3.20100   0.11000   1.000 32.48845 ? 18  ARG L CG  1 
ATOM   3546 C CD  . ARG C 3 18  ? 2.93300   3.44600   0.44300   1.000 36.15327 ? 18  ARG L CD  1 
ATOM   3547 N NE  . ARG C 3 18  ? 2.68300   3.35000   1.87600   1.000 53.07774 ? 18  ARG L NE  1 
ATOM   3548 C CZ  . ARG C 3 18  ? 1.90000   2.44100   2.44000   1.000 56.63589 ? 18  ARG L CZ  1 
ATOM   3549 N NH1 . ARG C 3 18  ? 1.27200   1.52600   1.71900   1.000 54.76253 ? 18  ARG L NH1 1 
ATOM   3550 N NH2 . ARG C 3 18  ? 1.74500   2.44800   3.76100   1.000 55.60208 ? 18  ARG L NH2 1 
ATOM   3551 N N   . VAL C 3 19  ? 6.76900   1.56400   -1.85400  1.000 25.68247 ? 19  VAL L N   1 
ATOM   3552 C CA  . VAL C 3 19  ? 6.81700   0.30100   -2.58000  1.000 28.13460 ? 19  VAL L CA  1 
ATOM   3553 C C   . VAL C 3 19  ? 6.15800   -0.77400  -1.72700  1.000 27.11214 ? 19  VAL L C   1 
ATOM   3554 O O   . VAL C 3 19  ? 6.46400   -0.90100  -0.53600  1.000 22.56654 ? 19  VAL L O   1 
ATOM   3555 C CB  . VAL C 3 19  ? 8.26400   -0.08900  -2.93300  1.000 28.77974 ? 19  VAL L CB  1 
ATOM   3556 C CG1 . VAL C 3 19  ? 8.33500   -1.53900  -3.38900  1.000 31.49336 ? 19  VAL L CG1 1 
ATOM   3557 C CG2 . VAL C 3 19  ? 8.81700   0.84600   -3.99800  1.000 26.24565 ? 19  VAL L CG2 1 
ATOM   3558 N N   . THR C 3 20  ? 5.25900   -1.54300  -2.33600  1.000 22.48216 ? 20  THR L N   1 
ATOM   3559 C CA  . THR C 3 20  ? 4.58600   -2.65000  -1.67000  1.000 26.56041 ? 20  THR L CA  1 
ATOM   3560 C C   . THR C 3 20  ? 4.79300   -3.92800  -2.47100  1.000 23.52103 ? 20  THR L C   1 
ATOM   3561 O O   . THR C 3 20  ? 4.65300   -3.92700  -3.69900  1.000 30.62980 ? 20  THR L O   1 
ATOM   3562 C CB  . THR C 3 20  ? 3.09000   -2.37100  -1.49700  1.000 29.03671 ? 20  THR L CB  1 
ATOM   3563 O OG1 . THR C 3 20  ? 2.52900   -1.96100  -2.75000  1.000 51.69340 ? 20  THR L OG1 1 
ATOM   3564 C CG2 . THR C 3 20  ? 2.86500   -1.28400  -0.45800  1.000 27.89166 ? 20  THR L CG2 1 
ATOM   3565 N N   . ILE C 3 21  ? 5.12700   -5.01100  -1.77300  1.000 24.55415 ? 21  ILE L N   1 
ATOM   3566 C CA  . ILE C 3 21  ? 5.30700   -6.32900  -2.37000  1.000 19.80814 ? 21  ILE L CA  1 
ATOM   3567 C C   . ILE C 3 21  ? 4.35600   -7.29100  -1.67500  1.000 22.37665 ? 21  ILE L C   1 
ATOM   3568 O O   . ILE C 3 21  ? 4.30200   -7.33200  -0.44000  1.000 21.12790 ? 21  ILE L O   1 
ATOM   3569 C CB  . ILE C 3 21  ? 6.76300   -6.81500  -2.24900  1.000 20.73645 ? 21  ILE L CB  1 
ATOM   3570 C CG1 . ILE C 3 21  ? 7.70800   -5.87200  -2.99600  1.000 19.84484 ? 21  ILE L CG1 1 
ATOM   3571 C CG2 . ILE C 3 21  ? 6.90100   -8.24000  -2.77000  1.000 16.05682 ? 21  ILE L CG2 1 
ATOM   3572 C CD1 . ILE C 3 21  ? 9.17300   -6.13400  -2.72200  1.000 20.20475 ? 21  ILE L CD1 1 
ATOM   3573 N N   . THR C 3 22  ? 3.61200   -8.06100  -2.46200  1.000 22.83199 ? 22  THR L N   1 
ATOM   3574 C CA  . THR C 3 22  ? 2.62400   -8.99400  -1.93700  1.000 22.21371 ? 22  THR L CA  1 
ATOM   3575 C C   . THR C 3 22  ? 3.16100   -10.41800 -2.00100  1.000 16.42614 ? 22  THR L C   1 
ATOM   3576 O O   . THR C 3 22  ? 3.85200   -10.79000 -2.95400  1.000 21.41691 ? 22  THR L O   1 
ATOM   3577 C CB  . THR C 3 22  ? 1.31200   -8.89100  -2.72000  1.000 26.64597 ? 22  THR L CB  1 
ATOM   3578 O OG1 . THR C 3 22  ? 0.89700   -7.52100  -2.78000  1.000 26.72461 ? 22  THR L OG1 1 
ATOM   3579 C CG2 . THR C 3 22  ? 0.21600   -9.71100  -2.05200  1.000 23.40174 ? 22  THR L CG2 1 
ATOM   3580 N N   . CYS C 3 23  ? 2.84600   -11.20800 -0.97600  1.000 18.77244 ? 23  CYS L N   1 
ATOM   3581 C CA  . CYS C 3 23  ? 3.20400   -12.61900 -0.91600  1.000 19.43211 ? 23  CYS L CA  1 
ATOM   3582 C C   . CYS C 3 23  ? 1.97600   -13.40800 -0.48700  1.000 23.10604 ? 23  CYS L C   1 
ATOM   3583 O O   . CYS C 3 23  ? 1.33100   -13.06300 0.50800   1.000 22.46378 ? 23  CYS L O   1 
ATOM   3584 C CB  . CYS C 3 23  ? 4.37000   -12.85600 0.05500   1.000 19.06451 ? 23  CYS L CB  1 
ATOM   3585 S SG  . CYS C 3 23  ? 4.79600   -14.59200 0.35100   1.000 29.34935 ? 23  CYS L SG  1 
ATOM   3586 N N   . ARG C 3 24  ? 1.64900   -14.45800 -1.23900  1.000 17.36404 ? 24  ARG L N   1 
ATOM   3587 C CA  . ARG C 3 24  ? 0.46900   -15.27400 -0.96400  1.000 23.55420 ? 24  ARG L CA  1 
ATOM   3588 C C   . ARG C 3 24  ? 0.87000   -16.74100 -0.90400  1.000 20.57520 ? 24  ARG L C   1 
ATOM   3589 O O   . ARG C 3 24  ? 1.32300   -17.29900 -1.92400  1.000 30.21831 ? 24  ARG L O   1 
ATOM   3590 C CB  . ARG C 3 24  ? -0.61500  -15.05600 -2.02300  1.000 25.42303 ? 24  ARG L CB  1 
ATOM   3591 C CG  . ARG C 3 24  ? -1.17800  -13.64700 -2.06400  1.000 21.06380 ? 24  ARG L CG  1 
ATOM   3592 C CD  . ARG C 3 24  ? -2.24200  -13.52800 -3.14200  1.000 38.94408 ? 24  ARG L CD  1 
ATOM   3593 N NE  . ARG C 3 24  ? -2.78000  -12.17700 -3.23800  1.000 30.76097 ? 24  ARG L NE  1 
ATOM   3594 C CZ  . ARG C 3 24  ? -2.49500  -11.33100 -4.21700  1.000 42.75928 ? 24  ARG L CZ  1 
ATOM   3595 N NH1 . ARG C 3 24  ? -1.66600  -11.66000 -5.19300  1.000 34.72558 ? 24  ARG L NH1 1 
ATOM   3596 N NH2 . ARG C 3 24  ? -3.05200  -10.12300 -4.21300  1.000 38.11323 ? 24  ARG L NH2 1 
ATOM   3597 N N   . PRO C 3 25  ? 0.72500   -17.40200 0.23900   1.000 20.36180 ? 25  PRO L N   1 
ATOM   3598 C CA  . PRO C 3 25  ? 0.97700   -18.84300 0.30200   1.000 25.00407 ? 25  PRO L CA  1 
ATOM   3599 C C   . PRO C 3 25  ? -0.20800  -19.63500 -0.23100  1.000 25.16477 ? 25  PRO L C   1 
ATOM   3600 O O   . PRO C 3 25  ? -1.33000  -19.13700 -0.34200  1.000 27.04180 ? 25  PRO L O   1 
ATOM   3601 C CB  . PRO C 3 25  ? 1.18200   -19.10100 1.79800   1.000 21.66244 ? 25  PRO L CB  1 
ATOM   3602 C CG  . PRO C 3 25  ? 0.39300   -18.02700 2.47400   1.000 27.87437 ? 25  PRO L CG  1 
ATOM   3603 C CD  . PRO C 3 25  ? 0.32700   -16.84300 1.54300   1.000 21.08332 ? 25  PRO L CD  1 
ATOM   3604 N N   . SER C 3 26  ? 0.06500   -20.89700 -0.56800  1.000 25.81429 ? 26  SER L N   1 
ATOM   3605 C CA  . SER C 3 26  ? -0.98500  -21.77400 -1.07000  1.000 27.33748 ? 26  SER L CA  1 
ATOM   3606 C C   . SER C 3 26  ? -1.94600  -22.22700 0.02100   1.000 36.14247 ? 26  SER L C   1 
ATOM   3607 O O   . SER C 3 26  ? -2.97100  -22.83900 -0.29800  1.000 30.01800 ? 26  SER L O   1 
ATOM   3608 C CB  . SER C 3 26  ? -0.37000  -22.99400 -1.75800  1.000 23.68161 ? 26  SER L CB  1 
ATOM   3609 O OG  . SER C 3 26  ? 0.64300   -23.57900 -0.95900  1.000 29.74717 ? 26  SER L OG  1 
ATOM   3610 N N   . GLN C 3 27  ? -1.64300  -21.94700 1.28800   1.000 29.18404 ? 27  GLN L N   1 
ATOM   3611 C CA  . GLN C 3 27  ? -2.54200  -22.26300 2.38800   1.000 29.89453 ? 27  GLN L CA  1 
ATOM   3612 C C   . GLN C 3 27  ? -2.27300  -21.29700 3.53200   1.000 28.90908 ? 27  GLN L C   1 
ATOM   3613 O O   . GLN C 3 27  ? -1.28700  -20.55500 3.53000   1.000 26.50878 ? 27  GLN L O   1 
ATOM   3614 C CB  . GLN C 3 27  ? -2.37800  -23.71200 2.85800   1.000 27.52854 ? 27  GLN L CB  1 
ATOM   3615 C CG  . GLN C 3 27  ? -0.94300  -24.11200 3.15200   1.000 29.89316 ? 27  GLN L CG  1 
ATOM   3616 C CD  . GLN C 3 27  ? -0.81800  -25.56700 3.55500   1.000 33.75811 ? 27  GLN L CD  1 
ATOM   3617 O OE1 . GLN C 3 27  ? -0.34200  -26.40000 2.78300   1.000 35.85776 ? 27  GLN L OE1 1 
ATOM   3618 N NE2 . GLN C 3 27  ? -1.24600  -25.88200 4.77200   1.000 33.53229 ? 27  GLN L NE2 1 
ATOM   3619 N N   . ASN C 3 28  ? -3.16400  -21.32000 4.52000   1.000 29.47947 ? 28  ASN L N   1 
ATOM   3620 C CA  . ASN C 3 28  ? -3.03600  -20.44200 5.67500   1.000 28.20948 ? 28  ASN L CA  1 
ATOM   3621 C C   . ASN C 3 28  ? -1.79900  -20.81200 6.48600   1.000 23.35491 ? 28  ASN L C   1 
ATOM   3622 O O   . ASN C 3 28  ? -1.61400  -21.97400 6.86100   1.000 23.01613 ? 28  ASN L O   1 
ATOM   3623 C CB  . ASN C 3 28  ? -4.29200  -20.52900 6.54200   1.000 36.55768 ? 28  ASN L CB  1 
ATOM   3624 C CG  . ASN C 3 28  ? -4.40100  -19.38400 7.53200   1.000 34.32373 ? 28  ASN L CG  1 
ATOM   3625 O OD1 . ASN C 3 28  ? -3.52200  -19.18600 8.37200   1.000 33.35460 ? 28  ASN L OD1 1 
ATOM   3626 N ND2 . ASN C 3 28  ? -5.48400  -18.62200 7.43700   1.000 30.94124 ? 28  ASN L ND2 1 
ATOM   3627 N N   . ILE C 3 29  ? -0.95400  -19.82000 6.75800   1.000 27.51120 ? 29  ILE L N   1 
ATOM   3628 C CA  . ILE C 3 29  ? 0.28300   -20.02700 7.49800   1.000 29.31223 ? 29  ILE L CA  1 
ATOM   3629 C C   . ILE C 3 29  ? 0.33100   -19.16900 8.76300   1.000 30.53624 ? 29  ILE L C   1 
ATOM   3630 O O   . ILE C 3 29  ? 1.39500   -18.99700 9.35100   1.000 22.87974 ? 29  ILE L O   1 
ATOM   3631 C CB  . ILE C 3 29  ? 1.51300   -19.76800 6.60700   1.000 23.13766 ? 29  ILE L CB  1 
ATOM   3632 C CG1 . ILE C 3 29  ? 1.48500   -18.34100 6.05700   1.000 21.18711 ? 29  ILE L CG1 1 
ATOM   3633 C CG2 . ILE C 3 29  ? 1.57800   -20.78100 5.47400   1.000 21.13742 ? 29  ILE L CG2 1 
ATOM   3634 C CD1 . ILE C 3 29  ? 2.77000   -17.92800 5.37300   1.000 22.22152 ? 29  ILE L CD1 1 
ATOM   3635 N N   . ARG C 3 30  ? -0.80600  -18.58100 9.10700   1.000 32.31108 ? 30  ARG L N   1 
ATOM   3636 C CA  . ARG C 3 30  ? -0.90800  -17.68000 10.25200  1.000 30.99945 ? 30  ARG L CA  1 
ATOM   3637 C C   . ARG C 3 30  ? 0.07100   -16.50100 10.13200  1.000 25.10509 ? 30  ARG L C   1 
ATOM   3638 O O   . ARG C 3 30  ? -0.01400  -15.73900 9.19700   1.000 23.67065 ? 30  ARG L O   1 
ATOM   3639 C CB  . ARG C 3 30  ? -0.76300  -18.45300 11.54500  1.000 28.85075 ? 30  ARG L CB  1 
ATOM   3640 C CG  . ARG C 3 30  ? -1.62700  -19.70400 11.56800  1.000 42.82284 ? 30  ARG L CG  1 
ATOM   3641 C CD  . ARG C 3 30  ? -1.33400  -20.57900 12.77000  1.000 58.06045 ? 30  ARG L CD  1 
ATOM   3642 N NE  . ARG C 3 30  ? -1.80700  -19.98000 14.01000  1.000 65.14558 ? 30  ARG L NE  1 
ATOM   3643 C CZ  . ARG C 3 30  ? -2.97100  -20.26200 14.58400  1.000 71.75845 ? 30  ARG L CZ  1 
ATOM   3644 N NH1 . ARG C 3 30  ? -3.79000  -21.15000 14.03600  1.000 73.72412 ? 30  ARG L NH1 1 
ATOM   3645 N NH2 . ARG C 3 30  ? -3.31400  -19.65700 15.71300  1.000 65.96409 ? 30  ARG L NH2 1 
ATOM   3646 N N   . SER C 3 31  ? 0.97900   -16.36400 11.07700  1.000 24.20449 ? 31  SER L N   1 
ATOM   3647 C CA  . SER C 3 31  ? 1.96700   -15.30500 10.93300  1.000 25.20132 ? 31  SER L CA  1 
ATOM   3648 C C   . SER C 3 31  ? 3.37300   -15.85900 10.74400  1.000 23.07097 ? 31  SER L C   1 
ATOM   3649 O O   . SER C 3 31  ? 4.35500   -15.14100 10.95900  1.000 26.15388 ? 31  SER L O   1 
ATOM   3650 C CB  . SER C 3 31  ? 1.92300   -14.37400 12.14400  1.000 27.55645 ? 31  SER L CB  1 
ATOM   3651 O OG  . SER C 3 31  ? 0.67300   -13.71800 12.23800  1.000 28.43747 ? 31  SER L OG  1 
ATOM   3652 N N   . PHE C 3 32  ? 3.49000   -17.12700 10.34800  1.000 21.27278 ? 32  PHE L N   1 
ATOM   3653 C CA  . PHE C 3 32  ? 4.78800   -17.77600 10.17000  1.000 21.17644 ? 32  PHE L CA  1 
ATOM   3654 C C   . PHE C 3 32  ? 5.37700   -17.41800 8.80400   1.000 21.59635 ? 32  PHE L C   1 
ATOM   3655 O O   . PHE C 3 32  ? 5.57900   -18.26300 7.93300   1.000 24.05171 ? 32  PHE L O   1 
ATOM   3656 C CB  . PHE C 3 32  ? 4.64800   -19.28500 10.33400  1.000 20.97297 ? 32  PHE L CB  1 
ATOM   3657 C CG  . PHE C 3 32  ? 4.34800   -19.71800 11.74100  1.000 26.30708 ? 32  PHE L CG  1 
ATOM   3658 C CD1 . PHE C 3 32  ? 3.05500   -19.66400 12.23600  1.000 30.02333 ? 32  PHE L CD1 1 
ATOM   3659 C CD2 . PHE C 3 32  ? 5.35800   -20.18100 12.56800  1.000 24.11360 ? 32  PHE L CD2 1 
ATOM   3660 C CE1 . PHE C 3 32  ? 2.77500   -20.06200 13.53100  1.000 30.45711 ? 32  PHE L CE1 1 
ATOM   3661 C CE2 . PHE C 3 32  ? 5.08600   -20.58100 13.86500  1.000 26.36682 ? 32  PHE L CE2 1 
ATOM   3662 C CZ  . PHE C 3 32  ? 3.79100   -20.52100 14.34700  1.000 25.22369 ? 32  PHE L CZ  1 
ATOM   3663 N N   . LEU C 3 33  ? 5.62600   -16.13600 8.62300   1.000 17.38167 ? 33  LEU L N   1 
ATOM   3664 C CA  A LEU C 3 33  ? 6.15100   -15.61600 7.36700   0.854 20.67555 ? 33  LEU L CA  1 
ATOM   3665 C CA  B LEU C 3 33  ? 6.14800   -15.61300 7.35700   0.146 20.63593 ? 33  LEU L CA  1 
ATOM   3666 C C   . LEU C 3 33  ? 7.27300   -14.54100 7.60500   1.000 19.55208 ? 33  LEU L C   1 
ATOM   3667 O O   . LEU C 3 33  ? 7.18200   -13.63000 8.45000   1.000 17.57723 ? 33  LEU L O   1 
ATOM   3668 C CB  A LEU C 3 33  ? 5.03400   -15.04000 6.49700   0.854 19.98987 ? 33  LEU L CB  1 
ATOM   3669 C CB  B LEU C 3 33  ? 5.02300   -15.04400 6.48500   0.146 20.00944 ? 33  LEU L CB  1 
ATOM   3670 C CG  A LEU C 3 33  ? 5.45700   -14.48200 5.14300   0.854 21.15518 ? 33  LEU L CG  1 
ATOM   3671 C CG  B LEU C 3 33  ? 5.30000   -14.53200 5.06900   0.146 21.05348 ? 33  LEU L CG  1 
ATOM   3672 C CD1 A LEU C 3 33  ? 4.52100   -14.96300 4.05200   0.854 28.87649 ? 33  LEU L CD1 1 
ATOM   3673 C CD1 B LEU C 3 33  ? 6.58100   -15.08000 4.48200   0.146 19.20807 ? 33  LEU L CD1 1 
ATOM   3674 C CD2 A LEU C 3 33  ? 5.53800   -12.96600 5.17500   0.854 15.78078 ? 33  LEU L CD2 1 
ATOM   3675 C CD2 B LEU C 3 33  ? 4.15800   -14.91000 4.15300   0.146 25.91186 ? 33  LEU L CD2 1 
ATOM   3676 N N   . ASN C 3 34  ? 8.34800   -14.69700 6.87800   1.000 16.92463 ? 34  ASN L N   1 
ATOM   3677 C CA  . ASN C 3 34  ? 9.49300   -13.81400 7.02200   1.000 15.49542 ? 34  ASN L CA  1 
ATOM   3678 C C   . ASN C 3 34  ? 9.83200   -13.20400 5.67000   1.000 19.96108 ? 34  ASN L C   1 
ATOM   3679 O O   . ASN C 3 34  ? 9.53400   -13.78200 4.62100   1.000 20.42046 ? 34  ASN L O   1 
ATOM   3680 C CB  . ASN C 3 34  ? 10.70600  -14.57300 7.57600   1.000 14.03292 ? 34  ASN L CB  1 
ATOM   3681 C CG  . ASN C 3 34  ? 10.37000  -15.38600 8.81300   1.000 14.41648 ? 34  ASN L CG  1 
ATOM   3682 O OD1 . ASN C 3 34  ? 9.70300   -14.90200 9.72600   1.000 17.31057 ? 34  ASN L OD1 1 
ATOM   3683 N ND2 . ASN C 3 34  ? 10.82500  -16.63400 8.84300   1.000 17.86523 ? 34  ASN L ND2 1 
ATOM   3684 N N   . TRP C 3 35  ? 10.45800  -12.02800 5.70000   1.000 15.11940 ? 35  TRP L N   1 
ATOM   3685 C CA  . TRP C 3 35  ? 10.89400  -11.33500 4.49200   1.000 13.23111 ? 35  TRP L CA  1 
ATOM   3686 C C   . TRP C 3 35  ? 12.40800  -11.18800 4.49600   1.000 13.63289 ? 35  TRP L C   1 
ATOM   3687 O O   . TRP C 3 35  ? 12.98700  -10.70800 5.47700   1.000 16.86653 ? 35  TRP L O   1 
ATOM   3688 C CB  . TRP C 3 35  ? 10.24600  -9.95100  4.36300   1.000 17.85383 ? 35  TRP L CB  1 
ATOM   3689 C CG  . TRP C 3 35  ? 8.77400   -9.96100  4.06700   1.000 17.43816 ? 35  TRP L CG  1 
ATOM   3690 C CD1 . TRP C 3 35  ? 7.75200   -9.92300  4.97200   1.000 19.09751 ? 35  TRP L CD1 1 
ATOM   3691 C CD2 . TRP C 3 35  ? 8.16100   -10.01200 2.77400   1.000 17.92547 ? 35  TRP L CD2 1 
ATOM   3692 N NE1 . TRP C 3 35  ? 6.54200   -9.94300  4.32000   1.000 11.77407 ? 35  TRP L NE1 1 
ATOM   3693 C CE2 . TRP C 3 35  ? 6.76600   -10.00000 2.97000   1.000 19.10874 ? 35  TRP L CE2 1 
ATOM   3694 C CE3 . TRP C 3 35  ? 8.65800   -10.06800 1.46800   1.000 16.14436 ? 35  TRP L CE3 1 
ATOM   3695 C CZ2 . TRP C 3 35  ? 5.86300   -10.04100 1.90900   1.000 18.54175 ? 35  TRP L CZ2 1 
ATOM   3696 C CZ3 . TRP C 3 35  ? 7.76000   -10.10900 0.41800   1.000 16.57332 ? 35  TRP L CZ3 1 
ATOM   3697 C CH2 . TRP C 3 35  ? 6.37900   -10.09400 0.64400   1.000 17.18612 ? 35  TRP L CH2 1 
ATOM   3698 N N   . PHE C 3 36  ? 13.04000  -11.57900 3.39200   1.000 15.51385 ? 36  PHE L N   1 
ATOM   3699 C CA  . PHE C 3 36  ? 14.47900  -11.46600 3.21400   1.000 14.17646 ? 36  PHE L CA  1 
ATOM   3700 C C   . PHE C 3 36  ? 14.80500  -10.44600 2.13100   1.000 17.67084 ? 36  PHE L C   1 
ATOM   3701 O O   . PHE C 3 36  ? 14.03200  -10.24000 1.19100   1.000 13.92419 ? 36  PHE L O   1 
ATOM   3702 C CB  . PHE C 3 36  ? 15.10100  -12.81400 2.83700   1.000 12.29274 ? 36  PHE L CB  1 
ATOM   3703 C CG  . PHE C 3 36  ? 15.19000  -13.78600 3.97700   1.000 16.55524 ? 36  PHE L CG  1 
ATOM   3704 C CD1 . PHE C 3 36  ? 16.31300  -13.82100 4.78700   1.000 11.58150 ? 36  PHE L CD1 1 
ATOM   3705 C CD2 . PHE C 3 36  ? 14.15600  -14.67300 4.23000   1.000 14.63568 ? 36  PHE L CD2 1 
ATOM   3706 C CE1 . PHE C 3 36  ? 16.40000  -14.71900 5.83400   1.000 13.28974 ? 36  PHE L CE1 1 
ATOM   3707 C CE2 . PHE C 3 36  ? 14.23600  -15.57400 5.27500   1.000 16.82318 ? 36  PHE L CE2 1 
ATOM   3708 C CZ  . PHE C 3 36  ? 15.36000  -15.59700 6.07900   1.000 16.18045 ? 36  PHE L CZ  1 
ATOM   3709 N N   . GLN C 3 37  ? 15.96400  -9.81100  2.27200   1.000 17.77831 ? 37  GLN L N   1 
ATOM   3710 C CA  . GLN C 3 37  ? 16.50500  -8.91300  1.26200   1.000 12.85506 ? 37  GLN L CA  1 
ATOM   3711 C C   . GLN C 3 37  ? 17.84000  -9.46800  0.79300   1.000 11.99243 ? 37  GLN L C   1 
ATOM   3712 O O   . GLN C 3 37  ? 18.67400  -9.85900  1.61600   1.000 15.56174 ? 37  GLN L O   1 
ATOM   3713 C CB  . GLN C 3 37  ? 16.67200  -7.49600  1.81400   1.000 13.26525 ? 37  GLN L CB  1 
ATOM   3714 C CG  . GLN C 3 37  ? 17.40800  -6.54100  0.88900   1.000 14.73568 ? 37  GLN L CG  1 
ATOM   3715 C CD  . GLN C 3 37  ? 17.87600  -5.28800  1.60400   1.000 16.29602 ? 37  GLN L CD  1 
ATOM   3716 O OE1 . GLN C 3 37  ? 18.75700  -5.34200  2.46100   1.000 19.04655 ? 37  GLN L OE1 1 
ATOM   3717 N NE2 . GLN C 3 37  ? 17.28700  -4.15100  1.25300   1.000 19.70181 ? 37  GLN L NE2 1 
ATOM   3718 N N   . HIS C 3 38  ? 18.03900  -9.51300  -0.52300  1.000 12.26039 ? 38  HIS L N   1 
ATOM   3719 C CA  . HIS C 3 38  ? 19.23900  -10.10500 -1.10800  1.000 13.80790 ? 38  HIS L CA  1 
ATOM   3720 C C   . HIS C 3 38  ? 19.81500  -9.15100  -2.14600  1.000 15.82819 ? 38  HIS L C   1 
ATOM   3721 O O   . HIS C 3 38  ? 19.21600  -8.94300  -3.20600  1.000 11.87524 ? 38  HIS L O   1 
ATOM   3722 C CB  . HIS C 3 38  ? 18.93300  -11.46700 -1.73200  1.000 15.81391 ? 38  HIS L CB  1 
ATOM   3723 C CG  . HIS C 3 38  ? 20.15400  -12.23300 -2.13400  1.000 17.28138 ? 38  HIS L CG  1 
ATOM   3724 N ND1 . HIS C 3 38  ? 20.13400  -13.21400 -3.10200  1.000 19.45361 ? 38  HIS L ND1 1 
ATOM   3725 C CD2 . HIS C 3 38  ? 21.43400  -12.15900 -1.70000  1.000 21.67163 ? 38  HIS L CD2 1 
ATOM   3726 C CE1 . HIS C 3 38  ? 21.34900  -13.71300 -3.24600  1.000 22.34276 ? 38  HIS L CE1 1 
ATOM   3727 N NE2 . HIS C 3 38  ? 22.15700  -13.09000 -2.40600  1.000 21.26584 ? 38  HIS L NE2 1 
ATOM   3728 N N   . LYS C 3 39  ? 20.98100  -8.57700  -1.83900  1.000 15.04199 ? 39  LYS L N   1 
ATOM   3729 C CA  . LYS C 3 39  ? 21.74500  -7.71800  -2.72700  1.000 23.58752 ? 39  LYS L CA  1 
ATOM   3730 C C   . LYS C 3 39  ? 22.83000  -8.52200  -3.43500  1.000 24.01214 ? 39  LYS L C   1 
ATOM   3731 O O   . LYS C 3 39  ? 23.32900  -9.51100  -2.89000  1.000 21.07129 ? 39  LYS L O   1 
ATOM   3732 C CB  . LYS C 3 39  ? 22.38600  -6.56600  -1.94600  1.000 19.75635 ? 39  LYS L CB  1 
ATOM   3733 C CG  . LYS C 3 39  ? 21.40000  -5.50200  -1.48800  1.000 18.73874 ? 39  LYS L CG  1 
ATOM   3734 C CD  . LYS C 3 39  ? 21.92100  -4.75100  -0.27400  1.000 25.28392 ? 39  LYS L CD  1 
ATOM   3735 C CE  . LYS C 3 39  ? 20.81600  -3.94700  0.39200   1.000 25.44701 ? 39  LYS L CE  1 
ATOM   3736 N NZ  . LYS C 3 39  ? 21.28800  -2.61000  0.84700   1.000 26.59163 ? 39  LYS L NZ  1 
ATOM   3737 N N   . PRO C 3 40  ? 23.20500  -8.12800  -4.65200  1.000 31.38979 ? 40  PRO L N   1 
ATOM   3738 C CA  . PRO C 3 40  ? 24.18300  -8.91600  -5.41800  1.000 36.63003 ? 40  PRO L CA  1 
ATOM   3739 C C   . PRO C 3 40  ? 25.49700  -9.07900  -4.66600  1.000 31.73787 ? 40  PRO L C   1 
ATOM   3740 O O   . PRO C 3 40  ? 26.08800  -8.10700  -4.19000  1.000 32.03346 ? 40  PRO L O   1 
ATOM   3741 C CB  . PRO C 3 40  ? 24.36600  -8.10100  -6.70300  1.000 37.42305 ? 40  PRO L CB  1 
ATOM   3742 C CG  . PRO C 3 40  ? 23.11100  -7.30300  -6.82500  1.000 39.73575 ? 40  PRO L CG  1 
ATOM   3743 C CD  . PRO C 3 40  ? 22.70700  -6.97400  -5.42000  1.000 35.15242 ? 40  PRO L CD  1 
ATOM   3744 N N   . GLY C 3 41  ? 25.94700  -10.32900 -4.55800  1.000 34.45186 ? 41  GLY L N   1 
ATOM   3745 C CA  . GLY C 3 41  ? 27.19600  -10.65000 -3.90100  1.000 36.78398 ? 41  GLY L CA  1 
ATOM   3746 C C   . GLY C 3 41  ? 27.16800  -10.60600 -2.38900  1.000 43.14239 ? 41  GLY L C   1 
ATOM   3747 O O   . GLY C 3 41  ? 28.19000  -10.91000 -1.76100  1.000 38.66732 ? 41  GLY L O   1 
ATOM   3748 N N   . LYS C 3 42  ? 26.04100  -10.24600 -1.78200  1.000 29.34393 ? 42  LYS L N   1 
ATOM   3749 C CA  . LYS C 3 42  ? 25.93100  -10.12700 -0.33800  1.000 31.36597 ? 42  LYS L CA  1 
ATOM   3750 C C   . LYS C 3 42  ? 25.08300  -11.25700 0.22900   1.000 26.66873 ? 42  LYS L C   1 
ATOM   3751 O O   . LYS C 3 42  ? 24.32800  -11.92200 -0.48600  1.000 24.37839 ? 42  LYS L O   1 
ATOM   3752 C CB  . LYS C 3 42  ? 25.32800  -8.77400  0.05700   1.000 23.33767 ? 42  LYS L CB  1 
ATOM   3753 C CG  . LYS C 3 42  ? 26.10600  -7.57800  -0.45900  1.000 27.93805 ? 42  LYS L CG  1 
ATOM   3754 C CD  . LYS C 3 42  ? 27.30200  -7.27700  0.42900   1.000 43.44276 ? 42  LYS L CD  1 
ATOM   3755 C CE  . LYS C 3 42  ? 28.19400  -6.21200  -0.18800  1.000 56.41099 ? 42  LYS L CE  1 
ATOM   3756 N NZ  . LYS C 3 42  ? 29.55300  -6.73900  -0.49400  1.000 61.10535 ? 42  LYS L NZ  1 
ATOM   3757 N N   . ALA C 3 43  ? 25.22200  -11.46600 1.53400   1.000 20.23863 ? 43  ALA L N   1 
ATOM   3758 C CA  . ALA C 3 43  ? 24.43400  -12.48500 2.20700   1.000 20.81464 ? 43  ALA L CA  1 
ATOM   3759 C C   . ALA C 3 43  ? 22.98300  -12.02500 2.33400   1.000 23.21140 ? 43  ALA L C   1 
ATOM   3760 O O   . ALA C 3 43  ? 22.72700  -10.86300 2.66700   1.000 19.16315 ? 43  ALA L O   1 
ATOM   3761 C CB  . ALA C 3 43  ? 25.00900  -12.78400 3.59100   1.000 18.91072 ? 43  ALA L CB  1 
ATOM   3762 N N   . PRO C 3 44  ? 22.01700  -12.90100 2.05600   1.000 21.62107 ? 44  PRO L N   1 
ATOM   3763 C CA  . PRO C 3 44  ? 20.61400  -12.54200 2.28900   1.000 15.22059 ? 44  PRO L CA  1 
ATOM   3764 C C   . PRO C 3 44  ? 20.38800  -12.14300 3.74000   1.000 19.03972 ? 44  PRO L C   1 
ATOM   3765 O O   . PRO C 3 44  ? 20.94300  -12.74300 4.66400   1.000 18.34864 ? 44  PRO L O   1 
ATOM   3766 C CB  . PRO C 3 44  ? 19.85600  -13.82400 1.92600   1.000 18.29068 ? 44  PRO L CB  1 
ATOM   3767 C CG  . PRO C 3 44  ? 20.75500  -14.52200 0.95700   1.000 18.01569 ? 44  PRO L CG  1 
ATOM   3768 C CD  . PRO C 3 44  ? 22.15500  -14.22200 1.41900   1.000 14.30045 ? 44  PRO L CD  1 
ATOM   3769 N N   . LYS C 3 45  ? 19.57200  -11.11200 3.93200   1.000 15.88012 ? 45  LYS L N   1 
ATOM   3770 C CA  . LYS C 3 45  ? 19.36500  -10.50200 5.23700   1.000 18.66528 ? 45  LYS L CA  1 
ATOM   3771 C C   . LYS C 3 45  ? 17.89600  -10.59600 5.62100   1.000 14.41516 ? 45  LYS L C   1 
ATOM   3772 O O   . LYS C 3 45  ? 17.01800  -10.28700 4.81000   1.000 12.62043 ? 45  LYS L O   1 
ATOM   3773 C CB  . LYS C 3 45  ? 19.81900  -9.04000  5.23200   1.000 21.67927 ? 45  LYS L CB  1 
ATOM   3774 C CG  . LYS C 3 45  ? 19.45200  -8.26400  6.48600   1.000 24.85600 ? 45  LYS L CG  1 
ATOM   3775 C CD  . LYS C 3 45  ? 20.46700  -7.16600  6.76600   1.000 31.53828 ? 45  LYS L CD  1 
ATOM   3776 C CE  . LYS C 3 45  ? 19.82400  -5.79000  6.70300   1.000 34.88670 ? 45  LYS L CE  1 
ATOM   3777 N NZ  . LYS C 3 45  ? 20.77400  -4.75500  6.21000   1.000 47.55312 ? 45  LYS L NZ  1 
ATOM   3778 N N   . LEU C 3 46  ? 17.63600  -11.01700 6.85700   1.000 12.73966 ? 46  LEU L N   1 
ATOM   3779 C CA  . LEU C 3 46  ? 16.27600  -11.08000 7.38200   1.000 16.47221 ? 46  LEU L CA  1 
ATOM   3780 C C   . LEU C 3 46  ? 15.83600  -9.67800  7.78600   1.000 19.50858 ? 46  LEU L C   1 
ATOM   3781 O O   . LEU C 3 46  ? 16.39200  -9.08900  8.71900   1.000 14.45247 ? 46  LEU L O   1 
ATOM   3782 C CB  . LEU C 3 46  ? 16.20300  -12.03900 8.56700   1.000 19.51017 ? 46  LEU L CB  1 
ATOM   3783 C CG  . LEU C 3 46  ? 14.84000  -12.15700 9.25500   1.000 16.12706 ? 46  LEU L CG  1 
ATOM   3784 C CD1 . LEU C 3 46  ? 13.80800  -12.75000 8.30700   1.000 15.61469 ? 46  LEU L CD1 1 
ATOM   3785 C CD2 . LEU C 3 46  ? 14.94600  -12.98700 10.52400  1.000 17.59340 ? 46  LEU L CD2 1 
ATOM   3786 N N   . LEU C 3 47  ? 14.83700  -9.14300  7.08600   1.000 13.25033 ? 47  LEU L N   1 
ATOM   3787 C CA  . LEU C 3 47  ? 14.31500  -7.81400  7.37900   1.000 14.87471 ? 47  LEU L CA  1 
ATOM   3788 C C   . LEU C 3 47  ? 13.12600  -7.86700  8.33300   1.000 19.35668 ? 47  LEU L C   1 
ATOM   3789 O O   . LEU C 3 47  ? 13.10700  -7.16100  9.34600   1.000 15.49828 ? 47  LEU L O   1 
ATOM   3790 C CB  . LEU C 3 47  ? 13.90700  -7.10900  6.08200   1.000 14.33292 ? 47  LEU L CB  1 
ATOM   3791 C CG  . LEU C 3 47  ? 14.99800  -6.78500  5.06100   1.000 20.17640 ? 47  LEU L CG  1 
ATOM   3792 C CD1 . LEU C 3 47  ? 14.49000  -5.75100  4.06800   1.000 21.83918 ? 47  LEU L CD1 1 
ATOM   3793 C CD2 . LEU C 3 47  ? 16.26400  -6.29900  5.74900   1.000 20.16159 ? 47  LEU L CD2 1 
ATOM   3794 N N   . ILE C 3 48  ? 12.13100  -8.69200  8.01600   1.000 18.70996 ? 48  ILE L N   1 
ATOM   3795 C CA  . ILE C 3 48  ? 10.89800  -8.79500  8.78700   1.000 14.85230 ? 48  ILE L CA  1 
ATOM   3796 C C   . ILE C 3 48  ? 10.73200  -10.23800 9.23900   1.000 14.80535 ? 48  ILE L C   1 
ATOM   3797 O O   . ILE C 3 48  ? 10.84300  -11.16600 8.43000   1.000 14.72991 ? 48  ILE L O   1 
ATOM   3798 C CB  . ILE C 3 48  ? 9.67700   -8.33100  7.97000   1.000 14.99043 ? 48  ILE L CB  1 
ATOM   3799 C CG1 . ILE C 3 48  ? 9.89500   -6.91300  7.43200   1.000 13.00945 ? 48  ILE L CG1 1 
ATOM   3800 C CG2 . ILE C 3 48  ? 8.41400   -8.39800  8.81500   1.000 11.98837 ? 48  ILE L CG2 1 
ATOM   3801 C CD1 . ILE C 3 48  ? 9.88800   -5.84200  8.50400   1.000 15.11984 ? 48  ILE L CD1 1 
ATOM   3802 N N   . TYR C 3 49  ? 10.46500  -10.42200 10.52900  1.000 13.92725 ? 49  TYR L N   1 
ATOM   3803 C CA  . TYR C 3 49  ? 10.31800  -11.73700 11.13800  1.000 13.65967 ? 49  TYR L CA  1 
ATOM   3804 C C   . TYR C 3 49  ? 8.88800   -11.90000 11.62900  1.000 15.06555 ? 49  TYR L C   1 
ATOM   3805 O O   . TYR C 3 49  ? 8.33500   -10.98600 12.24800  1.000 17.02968 ? 49  TYR L O   1 
ATOM   3806 C CB  . TYR C 3 49  ? 11.30700  -11.90500 12.29500  1.000 15.23915 ? 49  TYR L CB  1 
ATOM   3807 C CG  . TYR C 3 49  ? 11.26200  -13.24100 13.00000  1.000 18.14652 ? 49  TYR L CG  1 
ATOM   3808 C CD1 . TYR C 3 49  ? 11.73100  -14.39200 12.38300  1.000 11.90301 ? 49  TYR L CD1 1 
ATOM   3809 C CD2 . TYR C 3 49  ? 10.77900  -13.34400 14.29900  1.000 16.83133 ? 49  TYR L CD2 1 
ATOM   3810 C CE1 . TYR C 3 49  ? 11.70300  -15.61300 13.03500  1.000 12.03539 ? 49  TYR L CE1 1 
ATOM   3811 C CE2 . TYR C 3 49  ? 10.74900  -14.55800 14.95800  1.000 16.43865 ? 49  TYR L CE2 1 
ATOM   3812 C CZ  . TYR C 3 49  ? 11.21300  -15.69000 14.32100  1.000 19.78898 ? 49  TYR L CZ  1 
ATOM   3813 O OH  . TYR C 3 49  ? 11.18500  -16.90300 14.97300  1.000 20.06834 ? 49  TYR L OH  1 
ATOM   3814 N N   . ALA C 3 50  ? 8.29400   -13.05900 11.34500  1.000 16.48690 ? 50  ALA L N   1 
ATOM   3815 C CA  . ALA C 3 50  ? 6.93200   -13.37600 11.77300  1.000 19.05964 ? 50  ALA L CA  1 
ATOM   3816 C C   . ALA C 3 50  ? 5.95500   -12.27800 11.35500  1.000 22.59107 ? 50  ALA L C   1 
ATOM   3817 O O   . ALA C 3 50  ? 5.25400   -11.68600 12.18000  1.000 18.49567 ? 50  ALA L O   1 
ATOM   3818 C CB  . ALA C 3 50  ? 6.87500   -13.62300 13.28200  1.000 21.39123 ? 50  ALA L CB  1 
ATOM   3819 N N   . ALA C 3 51  ? 5.95300   -11.98800 10.05100  1.000 17.67337 ? 51  ALA L N   1 
ATOM   3820 C CA  . ALA C 3 51  ? 4.98300   -11.11900 9.38900   1.000 18.22310 ? 51  ALA L CA  1 
ATOM   3821 C C   . ALA C 3 51  ? 5.19200   -9.62700  9.63700   1.000 15.95618 ? 51  ALA L C   1 
ATOM   3822 O O   . ALA C 3 51  ? 4.97900   -8.82700  8.72100   1.000 19.30475 ? 51  ALA L O   1 
ATOM   3823 C CB  . ALA C 3 51  ? 3.55200   -11.50500 9.78400   1.000 23.21080 ? 51  ALA L CB  1 
ATOM   3824 N N   . SER C 3 52  ? 5.60100   -9.21900  10.84500  1.000 16.36566 ? 52  SER L N   1 
ATOM   3825 C CA  . SER C 3 52  ? 5.57200   -7.79500  11.16100  1.000 18.65405 ? 52  SER L CA  1 
ATOM   3826 C C   . SER C 3 52  ? 6.71700   -7.27200  12.02100  1.000 20.16126 ? 52  SER L C   1 
ATOM   3827 O O   . SER C 3 52  ? 6.73900   -6.07000  12.29900  1.000 20.42628 ? 52  SER L O   1 
ATOM   3828 C CB  . SER C 3 52  ? 4.24500   -7.44400  11.85800  1.000 20.60674 ? 52  SER L CB  1 
ATOM   3829 O OG  . SER C 3 52  ? 4.10400   -8.16700  13.06900  1.000 24.00906 ? 52  SER L OG  1 
ATOM   3830 N N   . ASN C 3 53  ? 7.66200   -8.10400  12.44600  1.000 15.24510 ? 53  ASN L N   1 
ATOM   3831 C CA  . ASN C 3 53  ? 8.66600   -7.69000  13.42300  1.000 17.28729 ? 53  ASN L CA  1 
ATOM   3832 C C   . ASN C 3 53  ? 9.94500   -7.25200  12.71500  1.000 17.08409 ? 53  ASN L C   1 
ATOM   3833 O O   . ASN C 3 53  ? 10.64700  -8.07100  12.11200  1.000 17.80342 ? 53  ASN L O   1 
ATOM   3834 C CB  . ASN C 3 53  ? 8.93400   -8.81200  14.42100  1.000 16.84601 ? 53  ASN L CB  1 
ATOM   3835 C CG  . ASN C 3 53  ? 7.69600   -9.18400  15.21100  1.000 21.31177 ? 53  ASN L CG  1 
ATOM   3836 O OD1 . ASN C 3 53  ? 7.39100   -8.56800  16.23200  1.000 25.17492 ? 53  ASN L OD1 1 
ATOM   3837 N ND2 . ASN C 3 53  ? 6.96700   -10.18700 14.73600  1.000 18.14388 ? 53  ASN L ND2 1 
ATOM   3838 N N   . LEU C 3 54  ? 10.24600  -5.95700  12.80800  1.000 21.35078 ? 54  LEU L N   1 
ATOM   3839 C CA  . LEU C 3 54  ? 11.45800  -5.40100  12.22200  1.000 20.08222 ? 54  LEU L CA  1 
ATOM   3840 C C   . LEU C 3 54  ? 12.69000  -5.87400  12.98300  1.000 14.64677 ? 54  LEU L C   1 
ATOM   3841 O O   . LEU C 3 54  ? 12.70600  -5.89500  14.21600  1.000 17.57286 ? 54  LEU L O   1 
ATOM   3842 C CB  . LEU C 3 54  ? 11.39300  -3.87400  12.23800  1.000 17.77210 ? 54  LEU L CB  1 
ATOM   3843 C CG  . LEU C 3 54  ? 12.46200  -3.10400  11.46300  1.000 26.51292 ? 54  LEU L CG  1 
ATOM   3844 C CD1 . LEU C 3 54  ? 12.32600  -3.35800  9.97100   1.000 20.25822 ? 54  LEU L CD1 1 
ATOM   3845 C CD2 . LEU C 3 54  ? 12.38400  -1.61500  11.77400  1.000 26.37170 ? 54  LEU L CD2 1 
ATOM   3846 N N   . GLN C 3 55  ? 13.73000  -6.23900  12.24100  1.000 14.70859 ? 55  GLN L N   1 
ATOM   3847 C CA  . GLN C 3 55  ? 14.93900  -6.77900  12.84200  1.000 21.49868 ? 55  GLN L CA  1 
ATOM   3848 C C   . GLN C 3 55  ? 15.94000  -5.67100  13.15600  1.000 21.60068 ? 55  GLN L C   1 
ATOM   3849 O O   . GLN C 3 55  ? 15.86900  -4.56200  12.62100  1.000 18.31651 ? 55  GLN L O   1 
ATOM   3850 C CB  . GLN C 3 55  ? 15.56900  -7.82400  11.92200  1.000 18.69060 ? 55  GLN L CB  1 
ATOM   3851 C CG  . GLN C 3 55  ? 14.66800  -9.03000  11.70500  1.000 16.44640 ? 55  GLN L CG  1 
ATOM   3852 C CD  . GLN C 3 55  ? 14.22600  -9.64900  13.01800  1.000 21.60952 ? 55  GLN L CD  1 
ATOM   3853 O OE1 . GLN C 3 55  ? 14.99300  -10.35500 13.67200  1.000 19.51292 ? 55  GLN L OE1 1 
ATOM   3854 N NE2 . GLN C 3 55  ? 12.99000  -9.36900  13.42200  1.000 14.85157 ? 55  GLN L NE2 1 
ATOM   3855 N N   . SER C 3 56  ? 16.88400  -5.99400  14.04200  1.000 20.46805 ? 56  SER L N   1 
ATOM   3856 C CA  . SER C 3 56  ? 17.83800  -5.00600  14.53000  1.000 28.22060 ? 56  SER L CA  1 
ATOM   3857 C C   . SER C 3 56  ? 18.69200  -4.46200  13.39300  1.000 28.54141 ? 56  SER L C   1 
ATOM   3858 O O   . SER C 3 56  ? 19.23500  -5.22200  12.58600  1.000 24.34292 ? 56  SER L O   1 
ATOM   3859 C CB  . SER C 3 56  ? 18.72900  -5.62200  15.60900  1.000 22.72090 ? 56  SER L CB  1 
ATOM   3860 O OG  . SER C 3 56  ? 17.97400  -6.42600  16.49800  1.000 43.28596 ? 56  SER L OG  1 
ATOM   3861 N N   . GLY C 3 57  ? 18.80800  -3.13500  13.33400  1.000 28.33835 ? 57  GLY L N   1 
ATOM   3862 C CA  . GLY C 3 57  ? 19.60400  -2.47300  12.32700  1.000 30.51117 ? 57  GLY L CA  1 
ATOM   3863 C C   . GLY C 3 57  ? 18.88600  -2.18300  11.02800  1.000 32.22167 ? 57  GLY L C   1 
ATOM   3864 O O   . GLY C 3 57  ? 19.43700  -1.46400  10.18400  1.000 37.34281 ? 57  GLY L O   1 
ATOM   3865 N N   . VAL C 3 58  ? 17.68600  -2.71100  10.83600  1.000 27.34981 ? 58  VAL L N   1 
ATOM   3866 C CA  . VAL C 3 58  ? 16.94700  -2.48200  9.59300   1.000 23.73011 ? 58  VAL L CA  1 
ATOM   3867 C C   . VAL C 3 58  ? 16.22800  -1.13900  9.69000   1.000 21.71345 ? 58  VAL L C   1 
ATOM   3868 O O   . VAL C 3 58  ? 15.54100  -0.88800  10.69300  1.000 20.46852 ? 58  VAL L O   1 
ATOM   3869 C CB  . VAL C 3 58  ? 15.96200  -3.61700  9.33800   1.000 25.61656 ? 58  VAL L CB  1 
ATOM   3870 C CG1 . VAL C 3 58  ? 15.32300  -3.46600  7.96500   1.000 18.24210 ? 58  VAL L CG1 1 
ATOM   3871 C CG2 . VAL C 3 58  ? 16.66400  -4.96400  9.46000   1.000 18.31824 ? 58  VAL L CG2 1 
ATOM   3872 N N   . PRO C 3 59  ? 16.36400  -0.26200  8.69400   1.000 22.88891 ? 59  PRO L N   1 
ATOM   3873 C CA  . PRO C 3 59  ? 15.71400  1.05200   8.77000   1.000 20.86061 ? 59  PRO L CA  1 
ATOM   3874 C C   . PRO C 3 59  ? 14.20400  0.93100   8.91600   1.000 22.67583 ? 59  PRO L C   1 
ATOM   3875 O O   . PRO C 3 59  ? 13.57200  0.02100   8.37300   1.000 20.29318 ? 59  PRO L O   1 
ATOM   3876 C CB  . PRO C 3 59  ? 16.09400  1.71500   7.44000   1.000 20.27190 ? 59  PRO L CB  1 
ATOM   3877 C CG  . PRO C 3 59  ? 17.34300  1.01400   7.01200   1.000 32.04580 ? 59  PRO L CG  1 
ATOM   3878 C CD  . PRO C 3 59  ? 17.19600  -0.40100  7.48600   1.000 19.98116 ? 59  PRO L CD  1 
ATOM   3879 N N   . SER C 3 60  ? 13.62700  1.87900   9.65600   1.000 22.58370 ? 60  SER L N   1 
ATOM   3880 C CA  . SER C 3 60  ? 12.20300  1.85000   9.97000   1.000 25.62390 ? 60  SER L CA  1 
ATOM   3881 C C   . SER C 3 60  ? 11.31300  2.07600   8.75400   1.000 20.76687 ? 60  SER L C   1 
ATOM   3882 O O   . SER C 3 60  ? 10.09100  1.93500   8.87400   1.000 27.34102 ? 60  SER L O   1 
ATOM   3883 C CB  . SER C 3 60  ? 11.88400  2.89400   11.04100  1.000 22.93442 ? 60  SER L CB  1 
ATOM   3884 O OG  . SER C 3 60  ? 12.26600  4.19100   10.61900  1.000 30.97590 ? 60  SER L OG  1 
ATOM   3885 N N   . ARG C 3 61  ? 11.87900  2.42100   7.59500   1.000 18.71956 ? 61  ARG L N   1 
ATOM   3886 C CA  . ARG C 3 61  ? 11.06200  2.53700   6.39300   1.000 26.04153 ? 61  ARG L CA  1 
ATOM   3887 C C   . ARG C 3 61  ? 10.58600  1.18400   5.87900   1.000 19.85750 ? 61  ARG L C   1 
ATOM   3888 O O   . ARG C 3 61  ? 9.69400   1.14600   5.02400   1.000 20.56924 ? 61  ARG L O   1 
ATOM   3889 C CB  . ARG C 3 61  ? 11.83100  3.27100   5.29300   1.000 29.19610 ? 61  ARG L CB  1 
ATOM   3890 C CG  . ARG C 3 61  ? 12.96800  2.47700   4.67900   1.000 29.41487 ? 61  ARG L CG  1 
ATOM   3891 C CD  . ARG C 3 61  ? 13.54500  3.19900   3.47200   1.000 33.26377 ? 61  ARG L CD  1 
ATOM   3892 N NE  . ARG C 3 61  ? 14.82200  2.63000   3.06000   1.000 21.19865 ? 61  ARG L NE  1 
ATOM   3893 C CZ  . ARG C 3 61  ? 15.98700  2.92700   3.61800   1.000 24.13627 ? 61  ARG L CZ  1 
ATOM   3894 N NH1 . ARG C 3 61  ? 16.07500  3.80200   4.60700   1.000 32.75780 ? 61  ARG L NH1 1 
ATOM   3895 N NH2 . ARG C 3 61  ? 17.09000  2.33200   3.17500   1.000 24.54001 ? 61  ARG L NH2 1 
ATOM   3896 N N   . PHE C 3 62  ? 11.15300  0.08600   6.37100   1.000 17.76628 ? 62  PHE L N   1 
ATOM   3897 C CA  . PHE C 3 62  ? 10.66300  -1.24900  6.06000   1.000 22.88457 ? 62  PHE L CA  1 
ATOM   3898 C C   . PHE C 3 62  ? 9.64100   -1.67600  7.10400   1.000 17.72566 ? 62  PHE L C   1 
ATOM   3899 O O   . PHE C 3 62  ? 9.85000   -1.49400  8.30600   1.000 21.88430 ? 62  PHE L O   1 
ATOM   3900 C CB  . PHE C 3 62  ? 11.80900  -2.26200  6.02200   1.000 17.09155 ? 62  PHE L CB  1 
ATOM   3901 C CG  . PHE C 3 62  ? 12.79700  -2.02300  4.91900   1.000 18.04241 ? 62  PHE L CG  1 
ATOM   3902 C CD1 . PHE C 3 62  ? 13.87300  -1.17100  5.10700   1.000 16.43149 ? 62  PHE L CD1 1 
ATOM   3903 C CD2 . PHE C 3 62  ? 12.65400  -2.65400  3.69500   1.000 16.86233 ? 62  PHE L CD2 1 
ATOM   3904 C CE1 . PHE C 3 62  ? 14.78600  -0.95200  4.09400   1.000 21.70924 ? 62  PHE L CE1 1 
ATOM   3905 C CE2 . PHE C 3 62  ? 13.56300  -2.44000  2.67700   1.000 13.09483 ? 62  PHE L CE2 1 
ATOM   3906 C CZ  . PHE C 3 62  ? 14.63000  -1.58700  2.87700   1.000 16.30208 ? 62  PHE L CZ  1 
ATOM   3907 N N   . SER C 3 63  ? 8.53200   -2.24500  6.63800   1.000 20.90942 ? 63  SER L N   1 
ATOM   3908 C CA  . SER C 3 63  ? 7.51000   -2.75000  7.53900   1.000 20.45742 ? 63  SER L CA  1 
ATOM   3909 C C   . SER C 3 63  ? 6.81400   -3.93300  6.88400   1.000 18.11548 ? 63  SER L C   1 
ATOM   3910 O O   . SER C 3 63  ? 6.72600   -4.02100  5.65600   1.000 18.59886 ? 63  SER L O   1 
ATOM   3911 C CB  . SER C 3 63  ? 6.49100   -1.66300  7.90900   1.000 21.08002 ? 63  SER L CB  1 
ATOM   3912 O OG  . SER C 3 63  ? 5.73600   -1.26400  6.77800   1.000 21.30090 ? 63  SER L OG  1 
ATOM   3913 N N   . GLY C 3 64  ? 6.33200   -4.84800  7.71900   1.000 17.42387 ? 64  GLY L N   1 
ATOM   3914 C CA  . GLY C 3 64  ? 5.62400   -6.02200  7.25100   1.000 20.27190 ? 64  GLY L CA  1 
ATOM   3915 C C   . GLY C 3 64  ? 4.23300   -6.08100  7.85000   1.000 24.90066 ? 64  GLY L C   1 
ATOM   3916 O O   . GLY C 3 64  ? 4.01200   -5.66900  8.99000   1.000 28.15208 ? 64  GLY L O   1 
ATOM   3917 N N   . SER C 3 65  ? 3.29900   -6.59000  7.06700   1.000 20.46449 ? 65  SER L N   1 
ATOM   3918 C CA  . SER C 3 65  ? 1.94300   -6.75500  7.52800   1.000 27.17961 ? 65  SER L CA  1 
ATOM   3919 C C   . SER C 3 65  ? 1.27700   -7.96200  6.90400   1.000 26.09166 ? 65  SER L C   1 
ATOM   3920 O O   . SER C 3 65  ? 1.76500   -8.51300  5.93800   1.000 22.38742 ? 65  SER L O   1 
ATOM   3921 C CB  . SER C 3 65  ? 1.06600   -5.52000  7.23300   1.000 25.70195 ? 65  SER L CB  1 
ATOM   3922 O OG  . SER C 3 65  ? 0.88700   -5.32600  5.85200   1.000 39.24316 ? 65  SER L OG  1 
ATOM   3923 N N   . GLY C 3 66  ? 0.15900   -8.34600  7.47700   1.000 27.32747 ? 66  GLY L N   1 
ATOM   3924 C CA  . GLY C 3 66  ? -0.63000  -9.44400  6.96100   1.000 24.55329 ? 66  GLY L CA  1 
ATOM   3925 C C   . GLY C 3 66  ? -0.62400  -10.64600 7.89100   1.000 27.27332 ? 66  GLY L C   1 
ATOM   3926 O O   . GLY C 3 66  ? 0.09300   -10.70700 8.89100   1.000 24.59354 ? 66  GLY L O   1 
ATOM   3927 N N   . SER C 3 67  ? -1.46100  -11.61400 7.52600   1.000 22.57038 ? 67  SER L N   1 
ATOM   3928 C CA  . SER C 3 67  ? -1.59200  -12.87900 8.23900   1.000 27.73072 ? 67  SER L CA  1 
ATOM   3929 C C   . SER C 3 67  ? -2.44700  -13.80800 7.39200   1.000 27.62702 ? 67  SER L C   1 
ATOM   3930 O O   . SER C 3 67  ? -3.18200  -13.36400 6.50500   1.000 33.35144 ? 67  SER L O   1 
ATOM   3931 C CB  . SER C 3 67  ? -2.21000  -12.69300 9.62900   1.000 30.89841 ? 67  SER L CB  1 
ATOM   3932 O OG  . SER C 3 67  ? -3.56200  -12.28200 9.53400   1.000 35.25867 ? 67  SER L OG  1 
ATOM   3933 N N   . GLY C 3 68  ? -2.34000  -15.10200 7.67400   1.000 24.97004 ? 68  GLY L N   1 
ATOM   3934 C CA  . GLY C 3 68  ? -3.12800  -16.08800 6.96200   1.000 24.32223 ? 68  GLY L CA  1 
ATOM   3935 C C   . GLY C 3 68  ? -2.61600  -16.38900 5.56800   1.000 26.75694 ? 68  GLY L C   1 
ATOM   3936 O O   . GLY C 3 68  ? -1.67100  -17.16600 5.40500   1.000 23.93780 ? 68  GLY L O   1 
ATOM   3937 N N   . THR C 3 69  ? -3.23500  -15.78100 4.55000   1.000 24.26497 ? 69  THR L N   1 
ATOM   3938 C CA  . THR C 3 69  ? -2.88200  -16.05000 3.16100   1.000 23.57000 ? 69  THR L CA  1 
ATOM   3939 C C   . THR C 3 69  ? -2.52900  -14.79000 2.37800   1.000 25.49435 ? 69  THR L C   1 
ATOM   3940 O O   . THR C 3 69  ? -2.44700  -14.84800 1.14500   1.000 27.96741 ? 69  THR L O   1 
ATOM   3941 C CB  . THR C 3 69  ? -4.01900  -16.79000 2.44400   1.000 30.26236 ? 69  THR L CB  1 
ATOM   3942 O OG1 . THR C 3 69  ? -5.17900  -15.95000 2.38600   1.000 32.69355 ? 69  THR L OG1 1 
ATOM   3943 C CG2 . THR C 3 69  ? -4.36600  -18.08300 3.17100   1.000 36.47730 ? 69  THR L CG2 1 
ATOM   3944 N N   . GLU C 3 70  ? -2.32100  -13.65800 3.04800   1.000 24.03080 ? 70  GLU L N   1 
ATOM   3945 C CA  . GLU C 3 70  ? -1.94500  -12.42000 2.37300   1.000 29.05688 ? 70  GLU L CA  1 
ATOM   3946 C C   . GLU C 3 70  ? -0.95600  -11.66500 3.24500   1.000 25.16578 ? 70  GLU L C   1 
ATOM   3947 O O   . GLU C 3 70  ? -1.24500  -11.38300 4.41200   1.000 26.25341 ? 70  GLU L O   1 
ATOM   3948 C CB  . GLU C 3 70  ? -3.16900  -11.55100 2.07000   1.000 32.42936 ? 70  GLU L CB  1 
ATOM   3949 C CG  . GLU C 3 70  ? -2.83200  -10.25700 1.34700   1.000 42.24606 ? 70  GLU L CG  1 
ATOM   3950 C CD  . GLU C 3 70  ? -3.47800  -10.16500 -0.02000  1.000 54.01704 ? 70  GLU L CD  1 
ATOM   3951 O OE1 . GLU C 3 70  ? -3.97800  -11.19700 -0.51500  1.000 54.59805 ? 70  GLU L OE1 1 
ATOM   3952 O OE2 . GLU C 3 70  ? -3.47800  -9.06000  -0.60300  1.000 55.12512 ? 70  GLU L OE2 1 
ATOM   3953 N N   . PHE C 3 71  ? 0.20300   -11.33800 2.67800   1.000 21.18975 ? 71  PHE L N   1 
ATOM   3954 C CA  . PHE C 3 71  ? 1.25900   -10.64700 3.40100   1.000 19.90438 ? 71  PHE L CA  1 
ATOM   3955 C C   . PHE C 3 71  ? 1.83400   -9.55200  2.51600   1.000 20.24356 ? 71  PHE L C   1 
ATOM   3956 O O   . PHE C 3 71  ? 1.88700   -9.68700  1.29000   1.000 23.19940 ? 71  PHE L O   1 
ATOM   3957 C CB  . PHE C 3 71  ? 2.36700   -11.61200 3.84200   1.000 16.96881 ? 71  PHE L CB  1 
ATOM   3958 C CG  . PHE C 3 71  ? 1.88500   -12.71400 4.74300   1.000 25.46468 ? 71  PHE L CG  1 
ATOM   3959 C CD1 . PHE C 3 71  ? 1.28800   -13.84900 4.21600   1.000 23.09852 ? 71  PHE L CD1 1 
ATOM   3960 C CD2 . PHE C 3 71  ? 2.02700   -12.61400 6.11700   1.000 12.59290 ? 71  PHE L CD2 1 
ATOM   3961 C CE1 . PHE C 3 71  ? 0.84100   -14.86100 5.04000   1.000 22.73093 ? 71  PHE L CE1 1 
ATOM   3962 C CE2 . PHE C 3 71  ? 1.58500   -13.62400 6.94700   1.000 19.87108 ? 71  PHE L CE2 1 
ATOM   3963 C CZ  . PHE C 3 71  ? 0.98900   -14.75000 6.40800   1.000 23.72053 ? 71  PHE L CZ  1 
ATOM   3964 N N   . THR C 3 72  ? 2.26800   -8.46500  3.15000   1.000 22.25910 ? 72  THR L N   1 
ATOM   3965 C CA  . THR C 3 72  ? 2.76300   -7.29800  2.43500   1.000 21.81850 ? 72  THR L CA  1 
ATOM   3966 C C   . THR C 3 72  ? 4.04300   -6.79300  3.08100   1.000 23.50419 ? 72  THR L C   1 
ATOM   3967 O O   . THR C 3 72  ? 4.09800   -6.60700  4.30100   1.000 24.87253 ? 72  THR L O   1 
ATOM   3968 C CB  . THR C 3 72  ? 1.71700   -6.17600  2.41000   1.000 23.20281 ? 72  THR L CB  1 
ATOM   3969 O OG1 . THR C 3 72  ? 0.48400   -6.67900  1.88200   1.000 31.58597 ? 72  THR L OG1 1 
ATOM   3970 C CG2 . THR C 3 72  ? 2.19600   -5.01900  1.54500   1.000 29.45025 ? 72  THR L CG2 1 
ATOM   3971 N N   . LEU C 3 73  ? 5.06600   -6.57700  2.25900   1.000 18.89245 ? 73  LEU L N   1 
ATOM   3972 C CA  . LEU C 3 73  ? 6.25900   -5.84400  2.65300   1.000 20.94682 ? 73  LEU L CA  1 
ATOM   3973 C C   . LEU C 3 73  ? 6.17800   -4.44500  2.06000   1.000 16.56932 ? 73  LEU L C   1 
ATOM   3974 O O   . LEU C 3 73  ? 5.91200   -4.29000  0.86400   1.000 21.39603 ? 73  LEU L O   1 
ATOM   3975 C CB  . LEU C 3 73  ? 7.52800   -6.55200  2.17400   1.000 18.51014 ? 73  LEU L CB  1 
ATOM   3976 C CG  . LEU C 3 73  ? 8.84900   -5.82400  2.43600   1.000 18.31210 ? 73  LEU L CG  1 
ATOM   3977 C CD1 . LEU C 3 73  ? 9.22700   -5.88900  3.90800   1.000 19.45500 ? 73  LEU L CD1 1 
ATOM   3978 C CD2 . LEU C 3 73  ? 9.95900   -6.39700  1.57000   1.000 21.66219 ? 73  LEU L CD2 1 
ATOM   3979 N N   . THR C 3 74  ? 6.39200   -3.43100  2.89300   1.000 19.08393 ? 74  THR L N   1 
ATOM   3980 C CA  . THR C 3 74  ? 6.29000   -2.04200  2.46900   1.000 19.31299 ? 74  THR L CA  1 
ATOM   3981 C C   . THR C 3 74  ? 7.61900   -1.33500  2.69200   1.000 18.84070 ? 74  THR L C   1 
ATOM   3982 O O   . THR C 3 74  ? 8.20800   -1.43700  3.77300   1.000 20.13174 ? 74  THR L O   1 
ATOM   3983 C CB  . THR C 3 74  ? 5.17500   -1.30900  3.22300   1.000 23.56386 ? 74  THR L CB  1 
ATOM   3984 O OG1 . THR C 3 74  ? 3.93000   -1.98900  3.02500   1.000 23.35883 ? 74  THR L OG1 1 
ATOM   3985 C CG2 . THR C 3 74  ? 5.04300   0.12200   2.71900   1.000 22.05608 ? 74  THR L CG2 1 
ATOM   3986 N N   . ILE C 3 75  ? 8.08600   -0.63200  1.66400   1.000 21.77926 ? 75  ILE L N   1 
ATOM   3987 C CA  . ILE C 3 75  ? 9.20900   0.29200   1.76600   1.000 23.75649 ? 75  ILE L CA  1 
ATOM   3988 C C   . ILE C 3 75  ? 8.64700   1.68300   1.50600   1.000 23.70185 ? 75  ILE L C   1 
ATOM   3989 O O   . ILE C 3 75  ? 8.30600   2.02300   0.36600   1.000 25.98596 ? 75  ILE L O   1 
ATOM   3990 C CB  . ILE C 3 75  ? 10.33500  -0.05700  0.78300   1.000 23.44220 ? 75  ILE L CB  1 
ATOM   3991 C CG1 . ILE C 3 75  ? 10.62100  -1.56000  0.81200   1.000 26.59469 ? 75  ILE L CG1 1 
ATOM   3992 C CG2 . ILE C 3 75  ? 11.59600  0.72400   1.11700   1.000 19.42490 ? 75  ILE L CG2 1 
ATOM   3993 C CD1 . ILE C 3 75  ? 11.28900  -2.08100  -0.44400  1.000 23.00025 ? 75  ILE L CD1 1 
ATOM   3994 N N   . ARG C 3 76  ? 8.54200   2.49200   2.56400   1.000 25.23693 ? 76  ARG L N   1 
ATOM   3995 C CA  . ARG C 3 76  ? 7.76600   3.72700   2.48700   1.000 34.47258 ? 76  ARG L CA  1 
ATOM   3996 C C   . ARG C 3 76  ? 8.46100   4.82000   1.68400   1.000 40.94584 ? 76  ARG L C   1 
ATOM   3997 O O   . ARG C 3 76  ? 7.78200   5.64000   1.05400   1.000 52.69939 ? 76  ARG L O   1 
ATOM   3998 C CB  . ARG C 3 76  ? 7.45600   4.24200   3.89500   1.000 30.24636 ? 76  ARG L CB  1 
ATOM   3999 C CG  . ARG C 3 76  ? 8.58000   5.06800   4.50000   1.000 41.67804 ? 76  ARG L CG  1 
ATOM   4000 C CD  . ARG C 3 76  ? 8.13000   5.90700   5.68500   1.000 58.50676 ? 76  ARG L CD  1 
ATOM   4001 N NE  . ARG C 3 76  ? 9.23900   6.16400   6.59700   1.000 57.18512 ? 76  ARG L NE  1 
ATOM   4002 C CZ  . ARG C 3 76  ? 10.29000  6.92200   6.30600   1.000 58.26752 ? 76  ARG L CZ  1 
ATOM   4003 N NH1 . ARG C 3 76  ? 10.37400  7.58300   5.16200   1.000 56.53876 ? 76  ARG L NH1 1 
ATOM   4004 N NH2 . ARG C 3 76  ? 11.28000  7.02400   7.18800   1.000 58.14041 ? 76  ARG L NH2 1 
ATOM   4005 N N   . SER C 3 77  ? 9.80200   4.86200   1.69100   1.000 27.62158 ? 77  SER L N   1 
ATOM   4006 C CA  . SER C 3 77  ? 10.55800  5.93700   1.04100   1.000 25.56146 ? 77  SER L CA  1 
ATOM   4007 C C   . SER C 3 77  ? 11.79500  5.29700   0.41100   1.000 28.27906 ? 77  SER L C   1 
ATOM   4008 O O   . SER C 3 77  ? 12.88700  5.30500   0.98600   1.000 28.73383 ? 77  SER L O   1 
ATOM   4009 C CB  . SER C 3 77  ? 10.92200  7.04400   2.02800   1.000 27.46348 ? 77  SER L CB  1 
ATOM   4010 O OG  . SER C 3 77  ? 11.82800  7.96900   1.45500   1.000 43.77419 ? 77  SER L OG  1 
ATOM   4011 N N   . LEU C 3 78  ? 11.60600  4.75600   -0.79000  1.000 25.27986 ? 78  LEU L N   1 
ATOM   4012 C CA  . LEU C 3 78  ? 12.62700  3.95200   -1.44800  1.000 19.57134 ? 78  LEU L CA  1 
ATOM   4013 C C   . LEU C 3 78  ? 13.93500  4.72100   -1.58600  1.000 21.43331 ? 78  LEU L C   1 
ATOM   4014 O O   . LEU C 3 78  ? 13.95100  5.88000   -2.01000  1.000 21.67756 ? 78  LEU L O   1 
ATOM   4015 C CB  . LEU C 3 78  ? 12.12300  3.51000   -2.82100  1.000 18.70611 ? 78  LEU L CB  1 
ATOM   4016 C CG  . LEU C 3 78  ? 12.86100  2.38100   -3.53700  1.000 22.49495 ? 78  LEU L CG  1 
ATOM   4017 C CD1 . LEU C 3 78  ? 12.78000  1.09200   -2.73600  1.000 20.20762 ? 78  LEU L CD1 1 
ATOM   4018 C CD2 . LEU C 3 78  ? 12.27300  2.18800   -4.92300  1.000 22.86344 ? 78  LEU L CD2 1 
ATOM   4019 N N   . GLN C 3 79  ? 15.03000  4.07000   -1.21700  1.000 16.74104 ? 79  GLN L N   1 
ATOM   4020 C CA  . GLN C 3 79  ? 16.37300  4.61100   -1.31600  1.000 16.73994 ? 79  GLN L CA  1 
ATOM   4021 C C   . GLN C 3 79  ? 17.18100  3.84600   -2.35700  1.000 14.59004 ? 79  GLN L C   1 
ATOM   4022 O O   . GLN C 3 79  ? 16.85500  2.70200   -2.69300  1.000 20.17617 ? 79  GLN L O   1 
ATOM   4023 C CB  . GLN C 3 79  ? 17.07700  4.54200   0.04700   1.000 17.23507 ? 79  GLN L CB  1 
ATOM   4024 C CG  . GLN C 3 79  ? 16.39800  5.36900   1.12300   1.000 19.89013 ? 79  GLN L CG  1 
ATOM   4025 C CD  . GLN C 3 79  ? 16.38400  6.84700   0.79100   1.000 18.97270 ? 79  GLN L CD  1 
ATOM   4026 O OE1 . GLN C 3 79  ? 17.43400  7.47200   0.65400   1.000 17.68718 ? 79  GLN L OE1 1 
ATOM   4027 N NE2 . GLN C 3 79  ? 15.19100  7.41300   0.65600   1.000 20.39237 ? 79  GLN L NE2 1 
ATOM   4028 N N   . PRO C 3 80  ? 18.23800  4.45500   -2.90700  1.000 17.53557 ? 80  PRO L N   1 
ATOM   4029 C CA  . PRO C 3 80  ? 19.04300  3.73800   -3.91300  1.000 18.56246 ? 80  PRO L CA  1 
ATOM   4030 C C   . PRO C 3 80  ? 19.61900  2.42800   -3.40500  1.000 21.92950 ? 80  PRO L C   1 
ATOM   4031 O O   . PRO C 3 80  ? 19.65500  1.44200   -4.15200  1.000 18.14261 ? 80  PRO L O   1 
ATOM   4032 C CB  . PRO C 3 80  ? 20.14700  4.74700   -4.25900  1.000 16.95078 ? 80  PRO L CB  1 
ATOM   4033 C CG  . PRO C 3 80  ? 19.57100  6.07500   -3.91200  1.000 21.40056 ? 80  PRO L CG  1 
ATOM   4034 C CD  . PRO C 3 80  ? 18.69300  5.84400   -2.72200  1.000 16.71732 ? 80  PRO L CD  1 
ATOM   4035 N N   . GLU C 3 81  ? 20.06500  2.38600   -2.14800  1.000 13.99741 ? 81  GLU L N   1 
ATOM   4036 C CA  . GLU C 3 81  ? 20.63300  1.16400   -1.59000  1.000 19.45883 ? 81  GLU L CA  1 
ATOM   4037 C C   . GLU C 3 81  ? 19.60300  0.05400   -1.41700  1.000 15.93831 ? 81  GLU L C   1 
ATOM   4038 O O   . GLU C 3 81  ? 19.99000  -1.07700  -1.10700  1.000 16.24010 ? 81  GLU L O   1 
ATOM   4039 C CB  . GLU C 3 81  ? 21.30200  1.46200   -0.24600  1.000 14.76942 ? 81  GLU L CB  1 
ATOM   4040 C CG  . GLU C 3 81  ? 20.35500  2.00400   0.81400   1.000 18.41822 ? 81  GLU L CG  1 
ATOM   4041 C CD  . GLU C 3 81  ? 20.32900  3.52200   0.85500   1.000 26.59880 ? 81  GLU L CD  1 
ATOM   4042 O OE1 . GLU C 3 81  ? 20.41500  4.14900   -0.22100  1.000 22.47447 ? 81  GLU L OE1 1 
ATOM   4043 O OE2 . GLU C 3 81  ? 20.22000  4.08700   1.96500   1.000 21.39366 ? 81  GLU L OE2 1 
ATOM   4044 N N   . ASP C 3 82  ? 18.31400  0.34100   -1.60900  1.000 18.63666 ? 82  ASP L N   1 
ATOM   4045 C CA  . ASP C 3 82  ? 17.27500  -0.67600  -1.50000  1.000 15.47058 ? 82  ASP L CA  1 
ATOM   4046 C C   . ASP C 3 82  ? 17.15600  -1.54100  -2.74700  1.000 21.70677 ? 82  ASP L C   1 
ATOM   4047 O O   . ASP C 3 82  ? 16.30600  -2.43800  -2.77600  1.000 21.16705 ? 82  ASP L O   1 
ATOM   4048 C CB  . ASP C 3 82  ? 15.92200  -0.02500  -1.19400  1.000 17.19385 ? 82  ASP L CB  1 
ATOM   4049 C CG  . ASP C 3 82  ? 15.91400  0.70600   0.13500   1.000 18.70712 ? 82  ASP L CG  1 
ATOM   4050 O OD1 . ASP C 3 82  ? 16.77100  0.40100   0.99000   1.000 18.13682 ? 82  ASP L OD1 1 
ATOM   4051 O OD2 . ASP C 3 82  ? 15.04300  1.58100   0.32700   1.000 18.19131 ? 82  ASP L OD2 1 
ATOM   4052 N N   . PHE C 3 83  ? 17.96900  -1.29300  -3.77100  1.000 17.67082 ? 83  PHE L N   1 
ATOM   4053 C CA  . PHE C 3 83  ? 18.02900  -2.19700  -4.91200  1.000 20.94207 ? 83  PHE L CA  1 
ATOM   4054 C C   . PHE C 3 83  ? 18.43800  -3.58200  -4.43900  1.000 18.52624 ? 83  PHE L C   1 
ATOM   4055 O O   . PHE C 3 83  ? 19.51200  -3.75300  -3.84900  1.000 16.02897 ? 83  PHE L O   1 
ATOM   4056 C CB  . PHE C 3 83  ? 19.01800  -1.67700  -5.95600  1.000 17.42568 ? 83  PHE L CB  1 
ATOM   4057 C CG  . PHE C 3 83  ? 19.61500  -2.76000  -6.81400  1.000 22.71153 ? 83  PHE L CG  1 
ATOM   4058 C CD1 . PHE C 3 83  ? 18.83700  -3.45900  -7.72300  1.000 25.09179 ? 83  PHE L CD1 1 
ATOM   4059 C CD2 . PHE C 3 83  ? 20.95300  -3.09100  -6.69500  1.000 22.77203 ? 83  PHE L CD2 1 
ATOM   4060 C CE1 . PHE C 3 83  ? 19.39100  -4.46200  -8.50200  1.000 26.43255 ? 83  PHE L CE1 1 
ATOM   4061 C CE2 . PHE C 3 83  ? 21.50900  -4.08900  -7.47100  1.000 25.67240 ? 83  PHE L CE2 1 
ATOM   4062 C CZ  . PHE C 3 83  ? 20.72600  -4.77400  -8.37700  1.000 28.29740 ? 83  PHE L CZ  1 
ATOM   4063 N N   . ALA C 3 84  ? 17.58100  -4.56500  -4.70200  1.000 16.62657 ? 84  ALA L N   1 
ATOM   4064 C CA  . ALA C 3 84  ? 17.78300  -5.93000  -4.23700  1.000 14.29088 ? 84  ALA L CA  1 
ATOM   4065 C C   . ALA C 3 84  ? 16.64300  -6.79000  -4.76800  1.000 20.48797 ? 84  ALA L C   1 
ATOM   4066 O O   . ALA C 3 84  ? 15.70100  -6.29800  -5.39500  1.000 16.54805 ? 84  ALA L O   1 
ATOM   4067 C CB  . ALA C 3 84  ? 17.83900  -6.01300  -2.70900  1.000 15.45784 ? 84  ALA L CB  1 
ATOM   4068 N N   . THR C 3 85  ? 16.73700  -8.08500  -4.48900  1.000 13.92041 ? 85  THR L N   1 
ATOM   4069 C CA  . THR C 3 85  ? 15.63600  -9.01800  -4.67000  1.000 15.71181 ? 85  THR L CA  1 
ATOM   4070 C C   . THR C 3 85  ? 15.09500  -9.38300  -3.29700  1.000 13.43421 ? 85  THR L C   1 
ATOM   4071 O O   . THR C 3 85  ? 15.86600  -9.73900  -2.40000  1.000 19.20713 ? 85  THR L O   1 
ATOM   4072 C CB  . THR C 3 85  ? 16.09100  -10.27400 -5.41200  1.000 16.15960 ? 85  THR L CB  1 
ATOM   4073 O OG1 . THR C 3 85  ? 16.63100  -9.91100  -6.68900  1.000 21.87990 ? 85  THR L OG1 1 
ATOM   4074 C CG2 . THR C 3 85  ? 14.91400  -11.22300 -5.61600  1.000 17.59739 ? 85  THR L CG2 1 
ATOM   4075 N N   . TYR C 3 86  ? 13.78000  -9.29200  -3.13400  1.000 14.04123 ? 86  TYR L N   1 
ATOM   4076 C CA  . TYR C 3 86  ? 13.13000  -9.53200  -1.85400  1.000 15.97893 ? 86  TYR L CA  1 
ATOM   4077 C C   . TYR C 3 86  ? 12.35200  -10.83900 -1.91000  1.000 16.65918 ? 86  TYR L C   1 
ATOM   4078 O O   . TYR C 3 86  ? 11.61100  -11.08600 -2.86600  1.000 18.12375 ? 86  TYR L O   1 
ATOM   4079 C CB  . TYR C 3 86  ? 12.20600  -8.36800  -1.49100  1.000 15.82157 ? 86  TYR L CB  1 
ATOM   4080 C CG  . TYR C 3 86  ? 12.95400  -7.07600  -1.24500  1.000 12.82510 ? 86  TYR L CG  1 
ATOM   4081 C CD1 . TYR C 3 86  ? 13.29700  -6.23700  -2.29800  1.000 13.69861 ? 86  TYR L CD1 1 
ATOM   4082 C CD2 . TYR C 3 86  ? 13.32800  -6.70300  0.03700   1.000 13.76528 ? 86  TYR L CD2 1 
ATOM   4083 C CE1 . TYR C 3 86  ? 13.98900  -5.05900  -2.07800  1.000 14.62846 ? 86  TYR L CE1 1 
ATOM   4084 C CE2 . TYR C 3 86  ? 14.01800  -5.52600  0.26800   1.000 14.56952 ? 86  TYR L CE2 1 
ATOM   4085 C CZ  . TYR C 3 86  ? 14.34500  -4.71000  -0.79200  1.000 14.13126 ? 86  TYR L CZ  1 
ATOM   4086 O OH  . TYR C 3 86  ? 15.03300  -3.54000  -0.56800  1.000 13.81190 ? 86  TYR L OH  1 
ATOM   4087 N N   . TYR C 3 87  ? 12.53000  -11.67400 -0.88900  1.000 15.81737 ? 87  TYR L N   1 
ATOM   4088 C CA  . TYR C 3 87  ? 11.88800  -12.97800 -0.80700  1.000 18.21045 ? 87  TYR L CA  1 
ATOM   4089 C C   . TYR C 3 87  ? 11.03900  -13.06000 0.45100   1.000 19.13582 ? 87  TYR L C   1 
ATOM   4090 O O   . TYR C 3 87  ? 11.47000  -12.64200 1.53000   1.000 18.16270 ? 87  TYR L O   1 
ATOM   4091 C CB  . TYR C 3 87  ? 12.91900  -14.11700 -0.77400  1.000 17.09837 ? 87  TYR L CB  1 
ATOM   4092 C CG  . TYR C 3 87  ? 13.78800  -14.24300 -2.00200  1.000 18.92991 ? 87  TYR L CG  1 
ATOM   4093 C CD1 . TYR C 3 87  ? 13.39200  -15.02400 -3.07700  1.000 14.98661 ? 87  TYR L CD1 1 
ATOM   4094 C CD2 . TYR C 3 87  ? 15.01700  -13.59900 -2.07600  1.000 17.17210 ? 87  TYR L CD2 1 
ATOM   4095 C CE1 . TYR C 3 87  ? 14.18700  -15.15100 -4.19900  1.000 18.08288 ? 87  TYR L CE1 1 
ATOM   4096 C CE2 . TYR C 3 87  ? 15.82000  -13.72000 -3.19500  1.000 17.19303 ? 87  TYR L CE2 1 
ATOM   4097 C CZ  . TYR C 3 87  ? 15.39800  -14.49700 -4.25300  1.000 18.83805 ? 87  TYR L CZ  1 
ATOM   4098 O OH  . TYR C 3 87  ? 16.19000  -14.62300 -5.37000  1.000 21.42260 ? 87  TYR L OH  1 
ATOM   4099 N N   . CYS C 3 88  ? 9.83700   -13.60800 0.31300   1.000 13.44351 ? 88  CYS L N   1 
ATOM   4100 C CA  . CYS C 3 88  ? 9.09000   -14.06500 1.47200   1.000 13.63305 ? 88  CYS L CA  1 
ATOM   4101 C C   . CYS C 3 88  ? 9.39300   -15.54100 1.70200   1.000 15.14771 ? 88  CYS L C   1 
ATOM   4102 O O   . CYS C 3 88  ? 9.76100   -16.27000 0.77700   1.000 17.93569 ? 88  CYS L O   1 
ATOM   4103 C CB  . CYS C 3 88  ? 7.58600   -13.84000 1.29600   1.000 19.11752 ? 88  CYS L CB  1 
ATOM   4104 S SG  . CYS C 3 88  ? 6.79600   -14.72500 -0.06900  1.000 18.21084 ? 88  CYS L SG  1 
ATOM   4105 N N   . GLN C 3 89  ? 9.26500   -15.97100 2.95300   1.000 17.20355 ? 89  GLN L N   1 
ATOM   4106 C CA  . GLN C 3 89  ? 9.57800   -17.34700 3.31400   1.000 20.71053 ? 89  GLN L CA  1 
ATOM   4107 C C   . GLN C 3 89  ? 8.63200   -17.78900 4.41600   1.000 15.01295 ? 89  GLN L C   1 
ATOM   4108 O O   . GLN C 3 89  ? 8.47000   -17.08300 5.41500   1.000 18.10905 ? 89  GLN L O   1 
ATOM   4109 C CB  . GLN C 3 89  ? 11.03500  -17.48300 3.77500   1.000 16.41057 ? 89  GLN L CB  1 
ATOM   4110 C CG  . GLN C 3 89  ? 11.39700  -18.85800 4.31800   1.000 17.61426 ? 89  GLN L CG  1 
ATOM   4111 C CD  . GLN C 3 89  ? 11.66100  -18.84400 5.81300   1.000 23.86271 ? 89  GLN L CD  1 
ATOM   4112 O OE1 . GLN C 3 89  ? 12.19600  -17.87500 6.35400   1.000 21.19156 ? 89  GLN L OE1 1 
ATOM   4113 N NE2 . GLN C 3 89  ? 11.28500  -19.92300 6.48900   1.000 18.80873 ? 89  GLN L NE2 1 
ATOM   4114 N N   . GLN C 3 90  ? 8.00500   -18.94500 4.22900   1.000 16.66965 ? 90  GLN L N   1 
ATOM   4115 C CA  . GLN C 3 90  ? 7.08300   -19.47800 5.21900   1.000 24.02769 ? 90  GLN L CA  1 
ATOM   4116 C C   . GLN C 3 90  ? 7.81600   -20.43300 6.15000   1.000 14.78314 ? 90  GLN L C   1 
ATOM   4117 O O   . GLN C 3 90  ? 8.66300   -21.22300 5.71800   1.000 17.65325 ? 90  GLN L O   1 
ATOM   4118 C CB  . GLN C 3 90  ? 5.89500   -20.17100 4.54000   1.000 16.48902 ? 90  GLN L CB  1 
ATOM   4119 C CG  . GLN C 3 90  ? 6.21600   -21.43100 3.74600   1.000 15.22942 ? 90  GLN L CG  1 
ATOM   4120 C CD  . GLN C 3 90  ? 6.24800   -22.68300 4.60000   1.000 21.24421 ? 90  GLN L CD  1 
ATOM   4121 O OE1 . GLN C 3 90  ? 5.69900   -22.71400 5.70100   1.000 21.21142 ? 90  GLN L OE1 1 
ATOM   4122 N NE2 . GLN C 3 90  ? 6.89700   -23.72400 4.09400   1.000 22.30249 ? 90  GLN L NE2 1 
ATOM   4123 N N   . SER C 3 91  ? 7.46100   -20.39100 7.42700   1.000 18.90702 ? 91  SER L N   1 
ATOM   4124 C CA  . SER C 3 91  ? 8.07300   -21.21100 8.46600   1.000 20.89266 ? 91  SER L CA  1 
ATOM   4125 C C   . SER C 3 91  ? 7.03000   -22.08600 9.17200   1.000 22.22653 ? 91  SER L C   1 
ATOM   4126 O O   . SER C 3 91  ? 7.26900   -22.56600 10.25700  1.000 17.64438 ? 91  SER L O   1 
ATOM   4127 C CB  . SER C 3 91  ? 8.72600   -20.28100 9.49700   1.000 19.02127 ? 91  SER L CB  1 
ATOM   4128 O OG  . SER C 3 91  ? 7.78000   -19.43400 10.09600  1.000 21.66842 ? 91  SER L OG  1 
ATOM   4129 N N   . TYR C 3 92  ? 5.87400   -22.24600 8.55100   1.000 23.02119 ? 92  TYR L N   1 
ATOM   4130 C CA  . TYR C 3 92  ? 4.76400   -23.00000 9.12400   1.000 25.31617 ? 92  TYR L CA  1 
ATOM   4131 C C   . TYR C 3 92  ? 4.90000   -24.49500 8.92700   1.000 25.97824 ? 92  TYR L C   1 
ATOM   4132 O O   . TYR C 3 92  ? 4.63200   -25.24100 9.83100   1.000 23.97521 ? 92  TYR L O   1 
ATOM   4133 C CB  . TYR C 3 92  ? 3.47400   -22.47300 8.48400   1.000 23.95693 ? 92  TYR L CB  1 
ATOM   4134 C CG  . TYR C 3 92  ? 2.17700   -22.96700 9.03700   1.000 34.11989 ? 92  TYR L CG  1 
ATOM   4135 C CD1 . TYR C 3 92  ? 1.65100   -22.43300 10.19700  1.000 37.03069 ? 92  TYR L CD1 1 
ATOM   4136 C CD2 . TYR C 3 92  ? 1.44400   -23.92400 8.36300   1.000 33.36081 ? 92  TYR L CD2 1 
ATOM   4137 C CE1 . TYR C 3 92  ? 0.44300   -22.86700 10.69400  1.000 41.80671 ? 92  TYR L CE1 1 
ATOM   4138 C CE2 . TYR C 3 92  ? 0.23500   -24.36600 8.84700   1.000 38.74175 ? 92  TYR L CE2 1 
ATOM   4139 C CZ  . TYR C 3 92  ? -0.25900  -23.83500 10.01500  1.000 51.98411 ? 92  TYR L CZ  1 
ATOM   4140 O OH  . TYR C 3 92  ? -1.46400  -24.27300 10.49800  1.000 62.41603 ? 92  TYR L OH  1 
ATOM   4141 N N   . ASN C 3 93  ? 5.29300   -24.91200 7.73500   1.000 24.90918 ? 93  ASN L N   1 
ATOM   4142 C CA  . ASN C 3 93  ? 5.48600   -26.30900 7.41900   1.000 26.31349 ? 93  ASN L CA  1 
ATOM   4143 C C   . ASN C 3 93  ? 6.87700   -26.61100 6.91100   1.000 26.36396 ? 93  ASN L C   1 
ATOM   4144 O O   . ASN C 3 93  ? 7.52000   -25.76900 6.34500   1.000 25.56289 ? 93  ASN L O   1 
ATOM   4145 C CB  . ASN C 3 93  ? 4.49700   -26.76900 6.34400   1.000 32.71017 ? 93  ASN L CB  1 
ATOM   4146 C CG  . ASN C 3 93  ? 3.14500   -27.14600 6.89200   1.000 45.14697 ? 93  ASN L CG  1 
ATOM   4147 O OD1 . ASN C 3 93  ? 2.80700   -26.84600 8.03200   1.000 55.40113 ? 93  ASN L OD1 1 
ATOM   4148 N ND2 . ASN C 3 93  ? 2.35100   -27.80900 6.06300   1.000 45.56694 ? 93  ASN L ND2 1 
ATOM   4149 N N   . THR C 3 94  ? 7.32300   -27.84000 7.10700   1.000 32.60992 ? 94  THR L N   1 
ATOM   4150 C CA  . THR C 3 94  ? 8.60600   -28.29300 6.61000   1.000 27.49668 ? 94  THR L CA  1 
ATOM   4151 C C   . THR C 3 94  ? 8.30000   -28.98700 5.31200   1.000 30.78813 ? 94  THR L C   1 
ATOM   4152 O O   . THR C 3 94  ? 7.34600   -29.73900 5.22900   1.000 39.22994 ? 94  THR L O   1 
ATOM   4153 C CB  . THR C 3 94  ? 9.29900   -29.25900 7.61700   1.000 28.33319 ? 94  THR L CB  1 
ATOM   4154 O OG1 . THR C 3 94  ? 10.53800  -29.71700 7.07400   1.000 51.07532 ? 94  THR L OG1 1 
ATOM   4155 C CG2 . THR C 3 94  ? 8.42800   -30.44500 7.91900   1.000 36.70538 ? 94  THR L CG2 1 
ATOM   4156 N N   . PRO C 3 95  ? 9.06200   -28.72200 4.27000   1.000 25.98391 ? 95  PRO L N   1 
ATOM   4157 C CA  . PRO C 3 95  ? 10.22400  -27.85600 4.25900   1.000 21.28935 ? 95  PRO L CA  1 
ATOM   4158 C C   . PRO C 3 95  ? 9.91600   -26.37100 4.14100   1.000 20.38950 ? 95  PRO L C   1 
ATOM   4159 O O   . PRO C 3 95  ? 8.95900   -25.97600 3.51800   1.000 21.16134 ? 95  PRO L O   1 
ATOM   4160 C CB  . PRO C 3 95  ? 10.94500  -28.30800 3.01500   1.000 27.15643 ? 95  PRO L CB  1 
ATOM   4161 C CG  . PRO C 3 95  ? 9.85600   -28.67600 2.07400   1.000 26.91686 ? 95  PRO L CG  1 
ATOM   4162 C CD  . PRO C 3 95  ? 8.75700   -29.23800 2.92700   1.000 30.99993 ? 95  PRO L CD  1 
ATOM   4163 N N   . PRO C 3 96  ? 10.73500  -25.56900 4.79000   1.000 21.32911 ? 96  PRO L N   1 
ATOM   4164 C CA  . PRO C 3 96  ? 10.58500  -24.13900 4.63500   1.000 21.70013 ? 96  PRO L CA  1 
ATOM   4165 C C   . PRO C 3 96  ? 10.66400  -23.80200 3.13400   1.000 16.62861 ? 96  PRO L C   1 
ATOM   4166 O O   . PRO C 3 96  ? 11.47100  -24.39200 2.45600   1.000 18.24321 ? 96  PRO L O   1 
ATOM   4167 C CB  . PRO C 3 96  ? 11.78300  -23.59100 5.39300   1.000 15.15742 ? 96  PRO L CB  1 
ATOM   4168 C CG  . PRO C 3 96  ? 12.15100  -24.63800 6.36900   1.000 23.87621 ? 96  PRO L CG  1 
ATOM   4169 C CD  . PRO C 3 96  ? 11.82000  -25.93300 5.71000   1.000 23.40930 ? 96  PRO L CD  1 
ATOM   4170 N N   . THR C 3 97  ? 9.84500   -22.88600 2.66300   1.000 15.59827 ? 97  THR L N   1 
ATOM   4171 C CA  . THR C 3 97  ? 9.79900   -22.52000 1.25000   1.000 17.64864 ? 97  THR L CA  1 
ATOM   4172 C C   . THR C 3 97  ? 9.86600   -21.00500 1.00700   1.000 14.46076 ? 97  THR L C   1 
ATOM   4173 O O   . THR C 3 97  ? 9.33100   -20.26000 1.78300   1.000 19.67823 ? 97  THR L O   1 
ATOM   4174 C CB  . THR C 3 97  ? 8.52100   -23.11300 0.55300   1.000 14.37779 ? 97  THR L CB  1 
ATOM   4175 O OG1 . THR C 3 97  ? 7.34700   -22.81100 1.30100   1.000 17.74781 ? 97  THR L OG1 1 
ATOM   4176 C CG2 . THR C 3 97  ? 8.65700   -24.60900 0.40300   1.000 23.76665 ? 97  THR L CG2 1 
ATOM   4177 N N   . PHE C 3 98  ? 10.49400  -20.57400 -0.08000  1.000 15.52834 ? 98  PHE L N   1 
ATOM   4178 C CA  . PHE C 3 98  ? 10.63400  -19.16200 -0.39800  1.000 16.79578 ? 98  PHE L CA  1 
ATOM   4179 C C   . PHE C 3 98  ? 9.78100   -18.81300 -1.60900  1.000 20.18603 ? 98  PHE L C   1 
ATOM   4180 O O   . PHE C 3 98  ? 9.49900   -19.66400 -2.45700  1.000 18.30486 ? 98  PHE L O   1 
ATOM   4181 C CB  . PHE C 3 98  ? 12.09200  -18.79800 -0.69900  1.000 15.58618 ? 98  PHE L CB  1 
ATOM   4182 C CG  . PHE C 3 98  ? 13.03900  -19.04700 0.44100   1.000 17.27581 ? 98  PHE L CG  1 
ATOM   4183 C CD1 . PHE C 3 98  ? 13.50900  -20.32400 0.70700   1.000 16.70680 ? 98  PHE L CD1 1 
ATOM   4184 C CD2 . PHE C 3 98  ? 13.48300  -17.99800 1.22800   1.000 18.03608 ? 98  PHE L CD2 1 
ATOM   4185 C CE1 . PHE C 3 98  ? 14.38700  -20.55000 1.74800   1.000 24.94403 ? 98  PHE L CE1 1 
ATOM   4186 C CE2 . PHE C 3 98  ? 14.36200  -18.21800 2.27000   1.000 16.65853 ? 98  PHE L CE2 1 
ATOM   4187 C CZ  . PHE C 3 98  ? 14.81500  -19.49600 2.53100   1.000 17.63526 ? 98  PHE L CZ  1 
ATOM   4188 N N   . GLY C 3 99  ? 9.38100   -17.54700 -1.68600  1.000 16.22262 ? 99  GLY L N   1 
ATOM   4189 C CA  . GLY C 3 99  ? 8.77300   -17.03900 -2.89500  1.000 15.65938 ? 99  GLY L CA  1 
ATOM   4190 C C   . GLY C 3 99  ? 9.78200   -16.95300 -4.02300  1.000 20.04973 ? 99  GLY L C   1 
ATOM   4191 O O   . GLY C 3 99  ? 10.99100  -17.09700 -3.83700  1.000 17.52986 ? 99  GLY L O   1 
ATOM   4192 N N   . GLN C 3 100 ? 9.26700   -16.71600 -5.23100  1.000 19.76453 ? 100 GLN L N   1 
ATOM   4193 C CA  . GLN C 3 100 ? 10.14500  -16.60800 -6.38900  1.000 21.56721 ? 100 GLN L CA  1 
ATOM   4194 C C   . GLN C 3 100 ? 11.00500  -15.35100 -6.35900  1.000 20.12724 ? 100 GLN L C   1 
ATOM   4195 O O   . GLN C 3 100 ? 11.96300  -15.26100 -7.13400  1.000 19.04580 ? 100 GLN L O   1 
ATOM   4196 C CB  . GLN C 3 100 ? 9.32500   -16.64300 -7.68000  1.000 24.83366 ? 100 GLN L CB  1 
ATOM   4197 C CG  . GLN C 3 100 ? 8.79500   -15.28700 -8.11900  1.000 28.91372 ? 100 GLN L CG  1 
ATOM   4198 C CD  . GLN C 3 100 ? 7.43200   -14.97800 -7.53200  1.000 29.42766 ? 100 GLN L CD  1 
ATOM   4199 O OE1 . GLN C 3 100 ? 6.98600   -15.63100 -6.58900  1.000 25.57548 ? 100 GLN L OE1 1 
ATOM   4200 N NE2 . GLN C 3 100 ? 6.76100   -13.97600 -8.09000  1.000 26.41965 ? 100 GLN L NE2 1 
ATOM   4201 N N   . GLY C 3 101 ? 10.69400  -14.39600 -5.50000  1.000 18.74074 ? 101 GLY L N   1 
ATOM   4202 C CA  . GLY C 3 101 ? 11.49900  -13.19900 -5.38300  1.000 23.64770 ? 101 GLY L CA  1 
ATOM   4203 C C   . GLY C 3 101 ? 10.92500  -12.03600 -6.16900  1.000 22.04036 ? 101 GLY L C   1 
ATOM   4204 O O   . GLY C 3 101 ? 10.26100  -12.20600 -7.19900  1.000 25.32394 ? 101 GLY L O   1 
ATOM   4205 N N   . THR C 3 102 ? 11.18200  -10.82800 -5.67300  1.000 16.14747 ? 102 THR L N   1 
ATOM   4206 C CA  . THR C 3 102 ? 10.75400  -9.59600  -6.32400  1.000 15.49051 ? 102 THR L CA  1 
ATOM   4207 C C   . THR C 3 102 ? 11.96500  -8.69200  -6.47700  1.000 21.51685 ? 102 THR L C   1 
ATOM   4208 O O   . THR C 3 102 ? 12.55700  -8.27200  -5.47800  1.000 20.47551 ? 102 THR L O   1 
ATOM   4209 C CB  . THR C 3 102 ? 9.65700   -8.89200  -5.52000  1.000 18.57959 ? 102 THR L CB  1 
ATOM   4210 O OG1 . THR C 3 102 ? 8.52100   -9.75700  -5.40100  1.000 18.57367 ? 102 THR L OG1 1 
ATOM   4211 C CG2 . THR C 3 102 ? 9.23700   -7.60200  -6.20900  1.000 18.09868 ? 102 THR L CG2 1 
ATOM   4212 N N   . LYS C 3 103 ? 12.33600  -8.40300  -7.72000  1.000 19.77485 ? 103 LYS L N   1 
ATOM   4213 C CA  . LYS C 3 103 ? 13.46300  -7.52600  -8.00900  1.000 21.26777 ? 103 LYS L CA  1 
ATOM   4214 C C   . LYS C 3 103 ? 12.98700  -6.07800  -7.99300  1.000 24.60657 ? 103 LYS L C   1 
ATOM   4215 O O   . LYS C 3 103 ? 12.10500  -5.70000  -8.77000  1.000 21.76722 ? 103 LYS L O   1 
ATOM   4216 C CB  . LYS C 3 103 ? 14.08600  -7.87500  -9.36000  1.000 24.57154 ? 103 LYS L CB  1 
ATOM   4217 C CG  . LYS C 3 103 ? 15.46700  -7.28000  -9.58000  1.000 36.95893 ? 103 LYS L CG  1 
ATOM   4218 C CD  . LYS C 3 103 ? 16.09100  -7.78300  -10.87400 1.000 49.30444 ? 103 LYS L CD  1 
ATOM   4219 C CE  . LYS C 3 103 ? 17.52600  -7.29800  -11.02300 1.000 53.78617 ? 103 LYS L CE  1 
ATOM   4220 N NZ  . LYS C 3 103 ? 18.50000  -8.25000  -10.41600 1.000 54.31466 ? 103 LYS L NZ  1 
ATOM   4221 N N   . VAL C 3 104 ? 13.56900  -5.27200  -7.11300  1.000 17.43716 ? 104 VAL L N   1 
ATOM   4222 C CA  . VAL C 3 104 ? 13.21100  -3.86600  -6.98100  1.000 17.13785 ? 104 VAL L CA  1 
ATOM   4223 C C   . VAL C 3 104 ? 14.31300  -3.04100  -7.63200  1.000 21.20575 ? 104 VAL L C   1 
ATOM   4224 O O   . VAL C 3 104 ? 15.45600  -3.03300  -7.16300  1.000 20.71208 ? 104 VAL L O   1 
ATOM   4225 C CB  . VAL C 3 104 ? 13.00400  -3.47100  -5.51400  1.000 22.48586 ? 104 VAL L CB  1 
ATOM   4226 C CG1 . VAL C 3 104 ? 12.84900  -1.96200  -5.39100  1.000 21.45910 ? 104 VAL L CG1 1 
ATOM   4227 C CG2 . VAL C 3 104 ? 11.78900  -4.18900  -4.94000  1.000 16.67528 ? 104 VAL L CG2 1 
ATOM   4228 N N   . GLU C 3 105 ? 13.97200  -2.35200  -8.71700  1.000 21.36358 ? 105 GLU L N   1 
ATOM   4229 C CA  . GLU C 3 105 ? 14.88400  -1.46400  -9.41900  1.000 23.74802 ? 105 GLU L CA  1 
ATOM   4230 C C   . GLU C 3 105 ? 14.52700  -0.01500  -9.11100  1.000 22.49132 ? 105 GLU L C   1 
ATOM   4231 O O   . GLU C 3 105 ? 13.39200  0.30400   -8.75200  1.000 20.96069 ? 105 GLU L O   1 
ATOM   4232 C CB  . GLU C 3 105 ? 14.83500  -1.70600  -10.93300 1.000 34.03850 ? 105 GLU L CB  1 
ATOM   4233 C CG  . GLU C 3 105 ? 15.23300  -3.11100  -11.36100 1.000 54.93606 ? 105 GLU L CG  1 
ATOM   4234 C CD  . GLU C 3 105 ? 16.73600  -3.29400  -11.45200 1.000 55.57158 ? 105 GLU L CD  1 
ATOM   4235 O OE1 . GLU C 3 105 ? 17.33000  -2.92200  -12.48600 1.000 46.32114 ? 105 GLU L OE1 1 
ATOM   4236 O OE2 . GLU C 3 105 ? 17.32400  -3.81200  -10.48400 1.000 65.26527 ? 105 GLU L OE2 1 
ATOM   4237 N N   . ILE C 3 106 ? 15.51300  0.86500   -9.26100  1.000 21.65627 ? 106 ILE L N   1 
ATOM   4238 C CA  . ILE C 3 106 ? 15.36700  2.27600   -8.92200  1.000 22.29805 ? 106 ILE L CA  1 
ATOM   4239 C C   . ILE C 3 106 ? 15.16500  3.07900   -10.19900 1.000 24.83146 ? 106 ILE L C   1 
ATOM   4240 O O   . ILE C 3 106 ? 15.97900  3.00000   -11.12800 1.000 24.72328 ? 106 ILE L O   1 
ATOM   4241 C CB  . ILE C 3 106 ? 16.59100  2.79200   -8.14600  1.000 28.23554 ? 106 ILE L CB  1 
ATOM   4242 C CG1 . ILE C 3 106 ? 16.85900  1.92600   -6.91200  1.000 29.29896 ? 106 ILE L CG1 1 
ATOM   4243 C CG2 . ILE C 3 106 ? 16.38900  4.24600   -7.74500  1.000 31.59492 ? 106 ILE L CG2 1 
ATOM   4244 C CD1 . ILE C 3 106 ? 15.64300  1.68100   -6.05100  1.000 24.90634 ? 106 ILE L CD1 1 
ATOM   4245 N N   . LYS C 3 107 ? 14.08100  3.85200   -10.24600 1.000 26.46030 ? 107 LYS L N   1 
ATOM   4246 C CA  . LYS C 3 107 ? 13.88100  4.81900   -11.31800 1.000 23.83189 ? 107 LYS L CA  1 
ATOM   4247 C C   . LYS C 3 107 ? 14.62100  6.10700   -10.98600 1.000 19.50163 ? 107 LYS L C   1 
ATOM   4248 O O   . LYS C 3 107 ? 14.47000  6.65400   -9.88900  1.000 32.40265 ? 107 LYS L O   1 
ATOM   4249 C CB  . LYS C 3 107 ? 12.39500  5.11000   -11.52200 1.000 24.77739 ? 107 LYS L CB  1 
ATOM   4250 C CG  . LYS C 3 107 ? 11.58000  3.93400   -12.01900 1.000 34.04920 ? 107 LYS L CG  1 
ATOM   4251 C CD  . LYS C 3 107 ? 10.58800  4.36000   -13.08900 1.000 45.49959 ? 107 LYS L CD  1 
ATOM   4252 C CE  . LYS C 3 107 ? 9.27900   3.59600   -12.96300 1.000 46.70681 ? 107 LYS L CE  1 
ATOM   4253 N NZ  . LYS C 3 107 ? 8.37700   4.20200   -11.94300 1.000 55.41476 ? 107 LYS L NZ  1 
ATOM   4254 N N   . ARG C 3 108 ? 15.41900  6.59400   -11.93200 1.000 23.79953 ? 108 ARG L N   1 
ATOM   4255 C CA  . ARG C 3 108 ? 16.18300  7.81500   -11.74100 1.000 25.61778 ? 108 ARG L CA  1 
ATOM   4256 C C   . ARG C 3 108 ? 16.18900  8.59900   -13.04700 1.000 30.21883 ? 108 ARG L C   1 
ATOM   4257 O O   . ARG C 3 108 ? 15.61900  8.17200   -14.05700 1.000 28.00985 ? 108 ARG L O   1 
ATOM   4258 C CB  . ARG C 3 108 ? 17.60600  7.50600   -11.26000 1.000 24.99258 ? 108 ARG L CB  1 
ATOM   4259 C CG  . ARG C 3 108 ? 18.43500  6.70700   -12.24600 1.000 20.00775 ? 108 ARG L CG  1 
ATOM   4260 C CD  . ARG C 3 108 ? 19.90000  7.08600   -12.14900 1.000 23.56127 ? 108 ARG L CD  1 
ATOM   4261 N NE  . ARG C 3 108 ? 20.14200  8.42500   -12.67200 1.000 25.34402 ? 108 ARG L NE  1 
ATOM   4262 C CZ  . ARG C 3 108 ? 21.21800  9.15200   -12.40400 1.000 21.98338 ? 108 ARG L CZ  1 
ATOM   4263 N NH1 . ARG C 3 108 ? 22.18200  8.69700   -11.62100 1.000 21.78699 ? 108 ARG L NH1 1 
ATOM   4264 N NH2 . ARG C 3 108 ? 21.32700  10.36900  -12.93000 1.000 28.29061 ? 108 ARG L NH2 1 
ATOM   4265 N N   . THR C 3 109 ? 16.83700  9.75900   -13.02400 1.000 26.97193 ? 109 THR L N   1 
ATOM   4266 C CA  . THR C 3 109 ? 16.88500  10.60200  -14.20700 1.000 24.62409 ? 109 THR L CA  1 
ATOM   4267 C C   . THR C 3 109 ? 17.84400  10.02200  -15.24200 1.000 29.52167 ? 109 THR L C   1 
ATOM   4268 O O   . THR C 3 109 ? 18.71100  9.19600   -14.93900 1.000 22.14206 ? 109 THR L O   1 
ATOM   4269 C CB  . THR C 3 109 ? 17.30600  12.02300  -13.84000 1.000 25.41109 ? 109 THR L CB  1 
ATOM   4270 O OG1 . THR C 3 109 ? 18.59300  11.99500  -13.20900 1.000 24.01741 ? 109 THR L OG1 1 
ATOM   4271 C CG2 . THR C 3 109 ? 16.29500  12.64100  -12.88900 1.000 23.50759 ? 109 THR L CG2 1 
ATOM   4272 N N   . VAL C 3 110 ? 17.67200  10.47000  -16.48800 1.000 28.06791 ? 110 VAL L N   1 
ATOM   4273 C CA  . VAL C 3 110 ? 18.51000  9.99000   -17.57700 1.000 27.21605 ? 110 VAL L CA  1 
ATOM   4274 C C   . VAL C 3 110 ? 19.94600  10.43300  -17.34700 1.000 22.98915 ? 110 VAL L C   1 
ATOM   4275 O O   . VAL C 3 110 ? 20.21000  11.59400  -17.00600 1.000 25.51657 ? 110 VAL L O   1 
ATOM   4276 C CB  . VAL C 3 110 ? 17.97400  10.49600  -18.92400 1.000 29.40496 ? 110 VAL L CB  1 
ATOM   4277 C CG1 . VAL C 3 110 ? 18.87200  10.04100  -20.06000 1.000 25.70059 ? 110 VAL L CG1 1 
ATOM   4278 C CG2 . VAL C 3 110 ? 16.54900  10.01200  -19.14200 1.000 23.72523 ? 110 VAL L CG2 1 
ATOM   4279 N N   . ALA C 3 111 ? 20.88200  9.50300   -17.51800 1.000 20.88694 ? 111 ALA L N   1 
ATOM   4280 C CA  . ALA C 3 111 ? 22.30400  9.77800   -17.36100 1.000 19.69081 ? 111 ALA L CA  1 
ATOM   4281 C C   . ALA C 3 111 ? 23.04000  9.29000   -18.59800 1.000 23.53137 ? 111 ALA L C   1 
ATOM   4282 O O   . ALA C 3 111 ? 22.88800  8.13100   -18.99900 1.000 21.97005 ? 111 ALA L O   1 
ATOM   4283 C CB  . ALA C 3 111 ? 22.86800  9.10700   -16.10400 1.000 20.15655 ? 111 ALA L CB  1 
ATOM   4284 N N   . ALA C 3 112 ? 23.82900  10.17200  -19.20000 1.000 27.25396 ? 112 ALA L N   1 
ATOM   4285 C CA  . ALA C 3 112 ? 24.57200  9.80600   -20.39500 1.000 22.33253 ? 112 ALA L CA  1 
ATOM   4286 C C   . ALA C 3 112 ? 25.78000  8.95000   -20.02300 1.000 25.76582 ? 112 ALA L C   1 
ATOM   4287 O O   . ALA C 3 112 ? 26.42100  9.19300   -18.99700 1.000 24.29822 ? 112 ALA L O   1 
ATOM   4288 C CB  . ALA C 3 112 ? 25.03400  11.05200  -21.14700 1.000 21.22574 ? 112 ALA L CB  1 
ATOM   4289 N N   . PRO C 3 113 ? 26.10500  7.94200   -20.82900 1.000 24.60364 ? 113 PRO L N   1 
ATOM   4290 C CA  . PRO C 3 113 ? 27.31200  7.15400   -20.56500 1.000 28.69284 ? 113 PRO L CA  1 
ATOM   4291 C C   . PRO C 3 113 ? 28.56100  7.88000   -21.03600 1.000 28.44867 ? 113 PRO L C   1 
ATOM   4292 O O   . PRO C 3 113 ? 28.57100  8.53400   -22.08100 1.000 25.39368 ? 113 PRO L O   1 
ATOM   4293 C CB  . PRO C 3 113 ? 27.08100  5.87600   -21.38000 1.000 23.56561 ? 113 PRO L CB  1 
ATOM   4294 C CG  . PRO C 3 113 ? 26.23100  6.33100   -22.52300 1.000 23.03789 ? 113 PRO L CG  1 
ATOM   4295 C CD  . PRO C 3 113 ? 25.33200  7.40900   -21.96500 1.000 20.12768 ? 113 PRO L CD  1 
ATOM   4296 N N   . SER C 3 114 ? 29.62100  7.76800   -20.24200 1.000 27.19922 ? 114 SER L N   1 
ATOM   4297 C CA  . SER C 3 114 ? 30.95200  8.14800   -20.68700 1.000 31.59031 ? 114 SER L CA  1 
ATOM   4298 C C   . SER C 3 114 ? 31.58700  6.93500   -21.35100 1.000 25.27499 ? 114 SER L C   1 
ATOM   4299 O O   . SER C 3 114 ? 31.63000  5.85000   -20.76100 1.000 28.12943 ? 114 SER L O   1 
ATOM   4300 C CB  . SER C 3 114 ? 31.80800  8.64300   -19.52000 1.000 26.61410 ? 114 SER L CB  1 
ATOM   4301 O OG  . SER C 3 114 ? 31.60700  7.85100   -18.36300 1.000 36.68724 ? 114 SER L OG  1 
ATOM   4302 N N   . VAL C 3 115 ? 32.05500  7.11300   -22.55600 1.000 24.94270 ? 115 VAL L N   1 
ATOM   4303 C CA  . VAL C 3 115 ? 32.55200  6.01300   -23.34000 1.000 20.76004 ? 115 VAL L CA  1 
ATOM   4304 C C   . VAL C 3 115 ? 34.05200  5.99400   -23.47000 1.000 23.58246 ? 115 VAL L C   1 
ATOM   4305 O O   . VAL C 3 115 ? 34.66600  7.02900   -23.65100 1.000 29.13876 ? 115 VAL L O   1 
ATOM   4306 C CB  . VAL C 3 115 ? 31.88800  6.02300   -24.74500 1.000 22.96158 ? 115 VAL L CB  1 
ATOM   4307 C CG1 . VAL C 3 115 ? 32.22900  4.76800   -25.52300 1.000 23.23580 ? 115 VAL L CG1 1 
ATOM   4308 C CG2 . VAL C 3 115 ? 30.38400  6.19100   -24.62200 1.000 21.42040 ? 115 VAL L CG2 1 
ATOM   4309 N N   . PHE C 3 116 ? 34.63000  4.81200   -23.37700 1.000 24.62014 ? 116 PHE L N   1 
ATOM   4310 C CA  . PHE C 3 116 ? 36.06200  4.64500   -23.45800 1.000 24.07218 ? 116 PHE L CA  1 
ATOM   4311 C C   . PHE C 3 116 ? 36.36500  3.41100   -24.27700 1.000 24.46408 ? 116 PHE L C   1 
ATOM   4312 O O   . PHE C 3 116 ? 35.59500  2.47300   -24.27400 1.000 24.12862 ? 116 PHE L O   1 
ATOM   4313 C CB  . PHE C 3 116 ? 36.68900  4.51000   -22.06600 1.000 27.50240 ? 116 PHE L CB  1 
ATOM   4314 C CG  . PHE C 3 116 ? 36.24800  5.53500   -21.07100 1.000 25.47566 ? 116 PHE L CG  1 
ATOM   4315 C CD1 . PHE C 3 116 ? 35.04200  5.40700   -20.41500 1.000 24.63746 ? 116 PHE L CD1 1 
ATOM   4316 C CD2 . PHE C 3 116 ? 37.06900  6.59200   -20.74600 1.000 30.62199 ? 116 PHE L CD2 1 
ATOM   4317 C CE1 . PHE C 3 116 ? 34.64500  6.33900   -19.48300 1.000 23.82119 ? 116 PHE L CE1 1 
ATOM   4318 C CE2 . PHE C 3 116 ? 36.68000  7.52500   -19.81100 1.000 33.58572 ? 116 PHE L CE2 1 
ATOM   4319 C CZ  . PHE C 3 116 ? 35.46400  7.39800   -19.17900 1.000 26.26846 ? 116 PHE L CZ  1 
ATOM   4320 N N   . ILE C 3 117 ? 37.47500  3.41600   -24.99000 1.000 27.33370 ? 117 ILE L N   1 
ATOM   4321 C CA  . ILE C 3 117 ? 37.87400  2.26500   -25.77700 1.000 24.03120 ? 117 ILE L CA  1 
ATOM   4322 C C   . ILE C 3 117 ? 39.26700  1.82500   -25.42700 1.000 29.35708 ? 117 ILE L C   1 
ATOM   4323 O O   . ILE C 3 117 ? 40.11900  2.63900   -25.13700 1.000 26.05815 ? 117 ILE L O   1 
ATOM   4324 C CB  . ILE C 3 117 ? 37.77000  2.53100   -27.28500 1.000 29.51821 ? 117 ILE L CB  1 
ATOM   4325 C CG1 . ILE C 3 117 ? 38.04400  1.25400   -28.08000 1.000 27.31646 ? 117 ILE L CG1 1 
ATOM   4326 C CG2 . ILE C 3 117 ? 38.70400  3.65700   -27.70200 1.000 33.77722 ? 117 ILE L CG2 1 
ATOM   4327 C CD1 . ILE C 3 117 ? 37.47400  1.28400   -29.47400 1.000 26.91187 ? 117 ILE L CD1 1 
ATOM   4328 N N   . PHE C 3 118 ? 39.48400  0.52900   -25.44100 1.000 24.68922 ? 118 PHE L N   1 
ATOM   4329 C CA  . PHE C 3 118 ? 40.75900  -0.02300  -25.06500 1.000 27.86366 ? 118 PHE L CA  1 
ATOM   4330 C C   . PHE C 3 118 ? 41.23500  -0.99300  -26.12200 1.000 33.12426 ? 118 PHE L C   1 
ATOM   4331 O O   . PHE C 3 118 ? 40.69200  -2.07300  -26.27000 1.000 34.26102 ? 118 PHE L O   1 
ATOM   4332 C CB  . PHE C 3 118 ? 40.69300  -0.75100  -23.71100 1.000 26.11829 ? 118 PHE L CB  1 
ATOM   4333 C CG  . PHE C 3 118 ? 40.24500  0.09300   -22.56900 1.000 31.69808 ? 118 PHE L CG  1 
ATOM   4334 C CD1 . PHE C 3 118 ? 41.16600  0.75700   -21.78500 1.000 27.17702 ? 118 PHE L CD1 1 
ATOM   4335 C CD2 . PHE C 3 118 ? 38.91000  0.18000   -22.24400 1.000 25.02549 ? 118 PHE L CD2 1 
ATOM   4336 C CE1 . PHE C 3 118 ? 40.75800  1.52100   -20.71600 1.000 31.28595 ? 118 PHE L CE1 1 
ATOM   4337 C CE2 . PHE C 3 118 ? 38.49800  0.94000   -21.17400 1.000 29.74630 ? 118 PHE L CE2 1 
ATOM   4338 C CZ  . PHE C 3 118 ? 39.42300  1.61500   -20.41200 1.000 25.72406 ? 118 PHE L CZ  1 
ATOM   4339 N N   . PRO C 3 119 ? 42.25500  -0.60300  -26.86800 1.000 38.99627 ? 119 PRO L N   1 
ATOM   4340 C CA  . PRO C 3 119 ? 42.84300  -1.51600  -27.84800 1.000 33.36401 ? 119 PRO L CA  1 
ATOM   4341 C C   . PRO C 3 119 ? 43.49000  -2.73500  -27.16600 1.000 32.77191 ? 119 PRO L C   1 
ATOM   4342 O O   . PRO C 3 119 ? 43.72500  -2.70500  -25.98300 1.000 30.86852 ? 119 PRO L O   1 
ATOM   4343 C CB  . PRO C 3 119 ? 43.92600  -0.67400  -28.49100 1.000 37.34390 ? 119 PRO L CB  1 
ATOM   4344 C CG  . PRO C 3 119 ? 43.68600  0.73100   -28.07900 1.000 43.50165 ? 119 PRO L CG  1 
ATOM   4345 C CD  . PRO C 3 119 ? 42.98300  0.66500   -26.76800 1.000 35.65810 ? 119 PRO L CD  1 
ATOM   4346 N N   . PRO C 3 120 ? 43.78500  -3.78000  -27.93700 1.000 35.69308 ? 120 PRO L N   1 
ATOM   4347 C CA  . PRO C 3 120 ? 44.39300  -4.96500  -27.32300 1.000 37.48895 ? 120 PRO L CA  1 
ATOM   4348 C C   . PRO C 3 120 ? 45.78000  -4.66200  -26.77900 1.000 38.30916 ? 120 PRO L C   1 
ATOM   4349 O O   . PRO C 3 120 ? 46.52800  -3.85300  -27.33100 1.000 49.02327 ? 120 PRO L O   1 
ATOM   4350 C CB  . PRO C 3 120 ? 44.45400  -5.97500  -28.47600 1.000 33.29901 ? 120 PRO L CB  1 
ATOM   4351 C CG  . PRO C 3 120 ? 43.43700  -5.49300  -29.45900 1.000 40.84830 ? 120 PRO L CG  1 
ATOM   4352 C CD  . PRO C 3 120 ? 43.46000  -4.00300  -29.35600 1.000 38.49545 ? 120 PRO L CD  1 
ATOM   4353 N N   . SER C 3 121 ? 46.11500  -5.32000  -25.67400 1.000 33.15017 ? 121 SER L N   1 
ATOM   4354 C CA  . SER C 3 121 ? 47.43500  -5.18000  -25.08300 1.000 33.44628 ? 121 SER L CA  1 
ATOM   4355 C C   . SER C 3 121 ? 48.45300  -6.00300  -25.86300 1.000 34.39656 ? 121 SER L C   1 
ATOM   4356 O O   . SER C 3 121 ? 48.11500  -7.00300  -26.50400 1.000 39.22034 ? 121 SER L O   1 
ATOM   4357 C CB  . SER C 3 121 ? 47.41900  -5.61800  -23.61800 1.000 36.59644 ? 121 SER L CB  1 
ATOM   4358 O OG  . SER C 3 121 ? 47.54300  -7.02500  -23.50500 1.000 40.43489 ? 121 SER L OG  1 
ATOM   4359 N N   . ASP C 3 122 ? 49.71300  -5.56600  -25.80600 1.000 44.60515 ? 122 ASP L N   1 
ATOM   4360 C CA  . ASP C 3 122 ? 50.77400  -6.28700  -26.50400 1.000 50.17431 ? 122 ASP L CA  1 
ATOM   4361 C C   . ASP C 3 122 ? 50.97700  -7.68200  -25.92800 1.000 41.34887 ? 122 ASP L C   1 
ATOM   4362 O O   . ASP C 3 122 ? 51.31300  -8.61400  -26.66700 1.000 45.61420 ? 122 ASP L O   1 
ATOM   4363 C CB  . ASP C 3 122 ? 52.07700  -5.49000  -26.44600 1.000 49.64308 ? 122 ASP L CB  1 
ATOM   4364 C CG  . ASP C 3 122 ? 52.05100  -4.26800  -27.34100 1.000 66.89123 ? 122 ASP L CG  1 
ATOM   4365 O OD1 . ASP C 3 122 ? 52.32000  -4.41400  -28.55200 1.000 69.26276 ? 122 ASP L OD1 1 
ATOM   4366 O OD2 . ASP C 3 122 ? 51.76600  -3.16100  -26.83500 1.000 66.21317 ? 122 ASP L OD2 1 
ATOM   4367 N N   . GLU C 3 123 ? 50.78000  -7.84300  -24.61700 1.000 42.40037 ? 123 GLU L N   1 
ATOM   4368 C CA  . GLU C 3 123 ? 50.87400  -9.16800  -24.01300 1.000 39.52271 ? 123 GLU L CA  1 
ATOM   4369 C C   . GLU C 3 123 ? 49.83200  -10.11300 -24.59700 1.000 48.03173 ? 123 GLU L C   1 
ATOM   4370 O O   . GLU C 3 123 ? 50.13400  -11.27300 -24.90000 1.000 47.22401 ? 123 GLU L O   1 
ATOM   4371 C CB  . GLU C 3 123 ? 50.71500  -9.06200  -22.49600 1.000 33.07785 ? 123 GLU L CB  1 
ATOM   4372 C CG  . GLU C 3 123 ? 50.99200  -10.35700 -21.74700 1.000 46.63701 ? 123 GLU L CG  1 
ATOM   4373 C CD  . GLU C 3 123 ? 50.58000  -10.28400 -20.29000 1.000 60.98862 ? 123 GLU L CD  1 
ATOM   4374 O OE1 . GLU C 3 123 ? 49.96200  -9.27100  -19.89500 1.000 51.56342 ? 123 GLU L OE1 1 
ATOM   4375 O OE2 . GLU C 3 123 ? 50.87100  -11.24000 -19.54000 1.000 59.82803 ? 123 GLU L OE2 1 
ATOM   4376 N N   . GLN C 3 124 ? 48.59700  -9.63200  -24.76600 1.000 46.01567 ? 124 GLN L N   1 
ATOM   4377 C CA  . GLN C 3 124 ? 47.55600  -10.46500 -25.35700 1.000 39.31663 ? 124 GLN L CA  1 
ATOM   4378 C C   . GLN C 3 124 ? 47.85000  -10.76000 -26.82200 1.000 41.54969 ? 124 GLN L C   1 
ATOM   4379 O O   . GLN C 3 124 ? 47.60500  -11.87500 -27.29700 1.000 51.07709 ? 124 GLN L O   1 
ATOM   4380 C CB  . GLN C 3 124 ? 46.19400  -9.78900  -25.20900 1.000 41.74298 ? 124 GLN L CB  1 
ATOM   4381 C CG  . GLN C 3 124 ? 45.02400  -10.75500 -25.24200 1.000 43.45109 ? 124 GLN L CG  1 
ATOM   4382 C CD  . GLN C 3 124 ? 43.77600  -10.14400 -25.84100 1.000 36.21462 ? 124 GLN L CD  1 
ATOM   4383 O OE1 . GLN C 3 124 ? 43.68300  -8.92800  -26.00800 1.000 41.03264 ? 124 GLN L OE1 1 
ATOM   4384 N NE2 . GLN C 3 124 ? 42.80500  -10.98700 -26.16700 1.000 37.53445 ? 124 GLN L NE2 1 
ATOM   4385 N N   . LEU C 3 125 ? 48.37200  -9.77300  -27.55400 1.000 45.68871 ? 125 LEU L N   1 
ATOM   4386 C CA  . LEU C 3 125 ? 48.74200  -10.00800 -28.94500 1.000 48.28466 ? 125 LEU L CA  1 
ATOM   4387 C C   . LEU C 3 125 ? 49.88800  -11.00400 -29.05700 1.000 57.77960 ? 125 LEU L C   1 
ATOM   4388 O O   . LEU C 3 125 ? 50.00100  -11.70500 -30.06900 1.000 59.02925 ? 125 LEU L O   1 
ATOM   4389 C CB  . LEU C 3 125 ? 49.11400  -8.69000  -29.62400 1.000 47.47633 ? 125 LEU L CB  1 
ATOM   4390 C CG  . LEU C 3 125 ? 48.00100  -7.64600  -29.71800 1.000 47.69066 ? 125 LEU L CG  1 
ATOM   4391 C CD1 . LEU C 3 125 ? 48.58100  -6.24000  -29.73500 1.000 50.14696 ? 125 LEU L CD1 1 
ATOM   4392 C CD2 . LEU C 3 125 ? 47.13800  -7.89400  -30.94600 1.000 50.76024 ? 125 LEU L CD2 1 
ATOM   4393 N N   . LYS C 3 126 ? 50.73500  -11.09200 -28.03100 1.000 53.10732 ? 126 LYS L N   1 
ATOM   4394 C CA  . LYS C 3 126 ? 51.80600  -12.08100 -28.00200 1.000 56.56383 ? 126 LYS L CA  1 
ATOM   4395 C C   . LYS C 3 126 ? 51.29000  -13.50900 -27.88000 1.000 55.45002 ? 126 LYS L C   1 
ATOM   4396 O O   . LYS C 3 126 ? 52.10400  -14.43900 -27.83800 1.000 68.82851 ? 126 LYS L O   1 
ATOM   4397 C CB  . LYS C 3 126 ? 52.76500  -11.77700 -26.85000 1.000 55.63936 ? 126 LYS L CB  1 
ATOM   4398 C CG  . LYS C 3 126 ? 54.23000  -11.72700 -27.25200 1.000 68.17270 ? 126 LYS L CG  1 
ATOM   4399 C CD  . LYS C 3 126 ? 55.09700  -11.21700 -26.11200 1.000 71.78323 ? 126 LYS L CD  1 
ATOM   4400 C CE  . LYS C 3 126 ? 55.36100  -9.72500  -26.24300 1.000 66.38879 ? 126 LYS L CE  1 
ATOM   4401 N NZ  . LYS C 3 126 ? 56.63200  -9.32200  -25.57900 1.000 83.57241 ? 126 LYS L NZ  1 
ATOM   4402 N N   . SER C 3 127 ? 49.97200  -13.70600 -27.82000 1.000 50.69081 ? 127 SER L N   1 
ATOM   4403 C CA  . SER C 3 127 ? 49.37900  -15.03000 -27.71100 1.000 49.49518 ? 127 SER L CA  1 
ATOM   4404 C C   . SER C 3 127 ? 48.48800  -15.38600 -28.89200 1.000 51.63011 ? 127 SER L C   1 
ATOM   4405 O O   . SER C 3 127 ? 47.98000  -16.51200 -28.94700 1.000 51.76913 ? 127 SER L O   1 
ATOM   4406 C CB  . SER C 3 127 ? 48.57300  -15.14300 -26.41000 1.000 60.56002 ? 127 SER L CB  1 
ATOM   4407 O OG  . SER C 3 127 ? 49.27600  -14.56300 -25.32500 1.000 58.79918 ? 127 SER L OG  1 
ATOM   4408 N N   . GLY C 3 128 ? 48.27900  -14.46800 -29.83100 1.000 50.42630 ? 128 GLY L N   1 
ATOM   4409 C CA  . GLY C 3 128 ? 47.49600  -14.74400 -31.01600 1.000 52.38779 ? 128 GLY L CA  1 
ATOM   4410 C C   . GLY C 3 128 ? 46.04500  -14.32200 -30.96500 1.000 52.20258 ? 128 GLY L C   1 
ATOM   4411 O O   . GLY C 3 128 ? 45.28200  -14.69100 -31.86600 1.000 46.60781 ? 128 GLY L O   1 
ATOM   4412 N N   . THR C 3 129 ? 45.63700  -13.56100 -29.95200 1.000 53.60497 ? 129 THR L N   1 
ATOM   4413 C CA  . THR C 3 129 ? 44.24900  -13.14000 -29.80900 1.000 52.60874 ? 129 THR L CA  1 
ATOM   4414 C C   . THR C 3 129 ? 44.21300  -11.66400 -29.44500 1.000 50.93469 ? 129 THR L C   1 
ATOM   4415 O O   . THR C 3 129 ? 44.96900  -11.21900 -28.57600 1.000 47.36383 ? 129 THR L O   1 
ATOM   4416 C CB  . THR C 3 129 ? 43.52500  -13.97300 -28.74200 1.000 51.69186 ? 129 THR L CB  1 
ATOM   4417 O OG1 . THR C 3 129 ? 43.32200  -15.30400 -29.23200 1.000 48.95188 ? 129 THR L OG1 1 
ATOM   4418 C CG2 . THR C 3 129 ? 42.17400  -13.36000 -28.40300 1.000 47.41744 ? 129 THR L CG2 1 
ATOM   4419 N N   . ALA C 3 130 ? 43.34200  -10.91200 -30.11400 1.000 50.05183 ? 130 ALA L N   1 
ATOM   4420 C CA  . ALA C 3 130 ? 43.18100  -9.48300  -29.87700 1.000 43.71870 ? 130 ALA L CA  1 
ATOM   4421 C C   . ALA C 3 130 ? 41.77200  -9.22000  -29.36700 1.000 38.37535 ? 130 ALA L C   1 
ATOM   4422 O O   . ALA C 3 130 ? 40.79200  -9.52500  -30.05600 1.000 37.05017 ? 130 ALA L O   1 
ATOM   4423 C CB  . ALA C 3 130 ? 43.45200  -8.68200  -31.15100 1.000 43.86415 ? 130 ALA L CB  1 
ATOM   4424 N N   . SER C 3 131 ? 41.67200  -8.65600  -28.16700 1.000 38.42664 ? 131 SER L N   1 
ATOM   4425 C CA  . SER C 3 131 ? 40.39700  -8.27800  -27.57100 1.000 30.80033 ? 131 SER L CA  1 
ATOM   4426 C C   . SER C 3 131 ? 40.32700  -6.76000  -27.48800 1.000 31.44901 ? 131 SER L C   1 
ATOM   4427 O O   . SER C 3 131 ? 41.20100  -6.12800  -26.88500 1.000 29.72282 ? 131 SER L O   1 
ATOM   4428 C CB  . SER C 3 131 ? 40.22600  -8.89900  -26.18400 1.000 27.17933 ? 131 SER L CB  1 
ATOM   4429 O OG  . SER C 3 131 ? 40.04800  -10.30200 -26.26500 1.000 31.49694 ? 131 SER L OG  1 
ATOM   4430 N N   . VAL C 3 132 ? 39.31600  -6.19300  -28.11200 1.000 30.94362 ? 132 VAL L N   1 
ATOM   4431 C CA  . VAL C 3 132 ? 39.12400  -4.76800  -28.06000 1.000 30.48393 ? 132 VAL L CA  1 
ATOM   4432 C C   . VAL C 3 132 ? 37.92300  -4.51700  -27.17600 1.000 28.74922 ? 132 VAL L C   1 
ATOM   4433 O O   . VAL C 3 132 ? 36.87400  -5.09500  -27.38500 1.000 28.47174 ? 132 VAL L O   1 
ATOM   4434 C CB  . VAL C 3 132 ? 38.91800  -4.17900  -29.45800 1.000 26.54220 ? 132 VAL L CB  1 
ATOM   4435 C CG1 . VAL C 3 132 ? 38.90400  -2.66500  -29.40100 1.000 29.20853 ? 132 VAL L CG1 1 
ATOM   4436 C CG2 . VAL C 3 132 ? 39.97900  -4.68000  -30.41300 1.000 32.96565 ? 132 VAL L CG2 1 
ATOM   4437 N N   . VAL C 3 133 ? 38.08400  -3.66200  -26.18400 1.000 22.45898 ? 133 VAL L N   1 
ATOM   4438 C CA  . VAL C 3 133 ? 37.00700  -3.41300  -25.24800 1.000 25.13043 ? 133 VAL L CA  1 
ATOM   4439 C C   . VAL C 3 133 ? 36.44600  -1.99400  -25.23600 1.000 24.86182 ? 133 VAL L C   1 
ATOM   4440 O O   . VAL C 3 133 ? 37.18200  -1.04500  -25.09200 1.000 28.22900 ? 133 VAL L O   1 
ATOM   4441 C CB  . VAL C 3 133 ? 37.43200  -3.81300  -23.81000 1.000 27.71984 ? 133 VAL L CB  1 
ATOM   4442 C CG1 . VAL C 3 133 ? 36.40200  -3.36000  -22.79300 1.000 31.18397 ? 133 VAL L CG1 1 
ATOM   4443 C CG2 . VAL C 3 133 ? 37.70900  -5.29900  -23.70400 1.000 25.23889 ? 133 VAL L CG2 1 
ATOM   4444 N N   . CYS C 3 134 ? 35.15100  -1.87300  -25.39400 1.000 22.01613 ? 134 CYS L N   1 
ATOM   4445 C CA  . CYS C 3 134 ? 34.47700  -0.58600  -25.33900 1.000 23.28980 ? 134 CYS L CA  1 
ATOM   4446 C C   . CYS C 3 134 ? 33.69500  -0.50800  -24.04600 1.000 25.04487 ? 134 CYS L C   1 
ATOM   4447 O O   . CYS C 3 134 ? 32.94800  -1.41600  -23.71700 1.000 19.85846 ? 134 CYS L O   1 
ATOM   4448 C CB  . CYS C 3 134 ? 33.54100  -0.38600  -26.53100 1.000 22.93911 ? 134 CYS L CB  1 
ATOM   4449 S SG  . CYS C 3 134 ? 32.66700  1.17200   -26.59400 1.000 30.61362 ? 134 CYS L SG  1 
ATOM   4450 N N   . LEU C 3 135 ? 33.88100  0.57300   -23.31900 1.000 20.70119 ? 135 LEU L N   1 
ATOM   4451 C CA  . LEU C 3 135 ? 33.21900  0.73000   -22.04700 1.000 19.10088 ? 135 LEU L CA  1 
ATOM   4452 C C   . LEU C 3 135 ? 32.17800  1.85200   -21.96000 1.000 22.34648 ? 135 LEU L C   1 
ATOM   4453 O O   . LEU C 3 135 ? 32.42900  2.95100   -22.39900 1.000 20.59811 ? 135 LEU L O   1 
ATOM   4454 C CB  . LEU C 3 135 ? 34.24700  0.93300   -20.94800 1.000 21.50768 ? 135 LEU L CB  1 
ATOM   4455 C CG  . LEU C 3 135 ? 33.76000  1.42200   -19.58400 1.000 25.04172 ? 135 LEU L CG  1 
ATOM   4456 C CD1 . LEU C 3 135 ? 32.88800  0.39000   -18.89300 1.000 19.57692 ? 135 LEU L CD1 1 
ATOM   4457 C CD2 . LEU C 3 135 ? 34.92500  1.82200   -18.69600 1.000 19.83608 ? 135 LEU L CD2 1 
ATOM   4458 N N   . LEU C 3 136 ? 31.02600  1.55000   -21.39300 1.000 16.78155 ? 136 LEU L N   1 
ATOM   4459 C CA  . LEU C 3 136 ? 29.99300  2.53400   -21.16900 1.000 16.70397 ? 136 LEU L CA  1 
ATOM   4460 C C   . LEU C 3 136 ? 29.87400  2.64900   -19.64000 1.000 22.82359 ? 136 LEU L C   1 
ATOM   4461 O O   . LEU C 3 136 ? 29.50200  1.69700   -18.98800 1.000 19.00723 ? 136 LEU L O   1 
ATOM   4462 C CB  . LEU C 3 136 ? 28.69400  2.15800   -21.85500 1.000 17.45677 ? 136 LEU L CB  1 
ATOM   4463 C CG  . LEU C 3 136 ? 28.53900  2.28300   -23.36200 1.000 14.71547 ? 136 LEU L CG  1 
ATOM   4464 C CD1 . LEU C 3 136 ? 29.50400  1.36900   -24.08700 1.000 16.49072 ? 136 LEU L CD1 1 
ATOM   4465 C CD2 . LEU C 3 136 ? 27.10400  1.98600   -23.75500 1.000 15.21866 ? 136 LEU L CD2 1 
ATOM   4466 N N   . ASN C 3 137 ? 30.12100  3.81700   -19.08900 1.000 19.10493 ? 137 ASN L N   1 
ATOM   4467 C CA  . ASN C 3 137 ? 30.22500  4.01900   -17.64800 1.000 22.71455 ? 137 ASN L CA  1 
ATOM   4468 C C   . ASN C 3 137 ? 29.04900  4.84200   -17.13500 1.000 23.45888 ? 137 ASN L C   1 
ATOM   4469 O O   . ASN C 3 137 ? 28.80900  5.95500   -17.61700 1.000 20.76894 ? 137 ASN L O   1 
ATOM   4470 C CB  . ASN C 3 137 ? 31.54500  4.70300   -17.29200 1.000 22.05328 ? 137 ASN L CB  1 
ATOM   4471 C CG  . ASN C 3 137 ? 32.10500  4.22800   -15.96900 1.000 28.36393 ? 137 ASN L CG  1 
ATOM   4472 O OD1 . ASN C 3 137 ? 32.37100  3.04000   -15.78500 1.000 40.63034 ? 137 ASN L OD1 1 
ATOM   4473 N ND2 . ASN C 3 137 ? 32.27700  5.15400   -15.03300 1.000 38.26327 ? 137 ASN L ND2 1 
ATOM   4474 N N   . ASN C 3 138 ? 28.32600  4.28700   -16.15900 1.000 20.06409 ? 138 ASN L N   1 
ATOM   4475 C CA  . ASN C 3 138 ? 27.34100  5.01100   -15.35900 1.000 17.91626 ? 138 ASN L CA  1 
ATOM   4476 C C   . ASN C 3 138 ? 26.27600  5.69900   -16.20500 1.000 20.06762 ? 138 ASN L C   1 
ATOM   4477 O O   . ASN C 3 138 ? 26.30300  6.92300   -16.36600 1.000 20.07375 ? 138 ASN L O   1 
ATOM   4478 C CB  . ASN C 3 138 ? 28.04400  6.04200   -14.47300 1.000 21.56548 ? 138 ASN L CB  1 
ATOM   4479 C CG  . ASN C 3 138 ? 29.02200  5.40800   -13.50400 1.000 27.57717 ? 138 ASN L CG  1 
ATOM   4480 O OD1 . ASN C 3 138 ? 29.18700  4.19000   -13.48000 1.000 22.46442 ? 138 ASN L OD1 1 
ATOM   4481 N ND2 . ASN C 3 138 ? 29.67600  6.23600   -12.69700 1.000 44.89672 ? 138 ASN L ND2 1 
ATOM   4482 N N   . PHE C 3 139 ? 25.32600  4.93200   -16.73300 1.000 21.25227 ? 139 PHE L N   1 
ATOM   4483 C CA  . PHE C 3 139 ? 24.26500  5.48500   -17.56100 1.000 23.80892 ? 139 PHE L CA  1 
ATOM   4484 C C   . PHE C 3 139 ? 22.91200  4.96400   -17.09600 1.000 19.29452 ? 139 PHE L C   1 
ATOM   4485 O O   . PHE C 3 139 ? 22.81300  3.94800   -16.40300 1.000 18.14124 ? 139 PHE L O   1 
ATOM   4486 C CB  . PHE C 3 139 ? 24.47500  5.15600   -19.04900 1.000 25.76902 ? 139 PHE L CB  1 
ATOM   4487 C CG  . PHE C 3 139 ? 24.50600  3.68300   -19.35100 1.000 24.84796 ? 139 PHE L CG  1 
ATOM   4488 C CD1 . PHE C 3 139 ? 25.70000  2.98200   -19.31400 1.000 17.39439 ? 139 PHE L CD1 1 
ATOM   4489 C CD2 . PHE C 3 139 ? 23.34500  3.00200   -19.68500 1.000 26.99560 ? 139 PHE L CD2 1 
ATOM   4490 C CE1 . PHE C 3 139 ? 25.73500  1.62800   -19.59300 1.000 16.85221 ? 139 PHE L CE1 1 
ATOM   4491 C CE2 . PHE C 3 139 ? 23.37400  1.64700   -19.96600 1.000 23.68967 ? 139 PHE L CE2 1 
ATOM   4492 C CZ  . PHE C 3 139 ? 24.57100  0.96000   -19.92000 1.000 19.01364 ? 139 PHE L CZ  1 
ATOM   4493 N N   . TYR C 3 140 ? 21.86400  5.68800   -17.49300 1.000 21.03692 ? 140 TYR L N   1 
ATOM   4494 C CA  . TYR C 3 140 ? 20.48500  5.32800   -17.21900 1.000 21.24854 ? 140 TYR L CA  1 
ATOM   4495 C C   . TYR C 3 140 ? 19.63500  5.94900   -18.31700 1.000 18.71299 ? 140 TYR L C   1 
ATOM   4496 O O   . TYR C 3 140 ? 19.85500  7.11900   -18.66500 1.000 25.12833 ? 140 TYR L O   1 
ATOM   4497 C CB  . TYR C 3 140 ? 20.01400  5.81600   -15.84300 1.000 19.93366 ? 140 TYR L CB  1 
ATOM   4498 C CG  . TYR C 3 140 ? 18.67800  5.24400   -15.42900 1.000 20.98922 ? 140 TYR L CG  1 
ATOM   4499 C CD1 . TYR C 3 140 ? 17.49000  5.88100   -15.77100 1.000 21.58081 ? 140 TYR L CD1 1 
ATOM   4500 C CD2 . TYR C 3 140 ? 18.60300  4.05900   -14.71000 1.000 19.80354 ? 140 TYR L CD2 1 
ATOM   4501 C CE1 . TYR C 3 140 ? 16.26600  5.35400   -15.40300 1.000 21.88959 ? 140 TYR L CE1 1 
ATOM   4502 C CE2 . TYR C 3 140 ? 17.38400  3.52600   -14.33600 1.000 17.35512 ? 140 TYR L CE2 1 
ATOM   4503 C CZ  . TYR C 3 140 ? 16.22000  4.17800   -14.68600 1.000 22.49973 ? 140 TYR L CZ  1 
ATOM   4504 O OH  . TYR C 3 140 ? 15.00200  3.65200   -14.31700 1.000 28.14922 ? 140 TYR L OH  1 
ATOM   4505 N N   . PRO C 3 141 ? 18.66100  5.21500   -18.87300 1.000 24.37097 ? 141 PRO L N   1 
ATOM   4506 C CA  . PRO C 3 141 ? 18.22400  3.85800   -18.51000 1.000 22.43524 ? 141 PRO L CA  1 
ATOM   4507 C C   . PRO C 3 141 ? 19.16000  2.75700   -18.99900 1.000 19.51565 ? 141 PRO L C   1 
ATOM   4508 O O   . PRO C 3 141 ? 20.16000  3.00800   -19.66300 1.000 22.67750 ? 141 PRO L O   1 
ATOM   4509 C CB  . PRO C 3 141 ? 16.83200  3.74500   -19.16800 1.000 27.98216 ? 141 PRO L CB  1 
ATOM   4510 C CG  . PRO C 3 141 ? 16.56400  5.06400   -19.87400 1.000 30.32621 ? 141 PRO L CG  1 
ATOM   4511 C CD  . PRO C 3 141 ? 17.89100  5.74400   -20.00800 1.000 21.46812 ? 141 PRO L CD  1 
ATOM   4512 N N   . ARG C 3 142 ? 18.81800  1.51100   -18.66700 1.000 30.42528 ? 142 ARG L N   1 
ATOM   4513 C CA  . ARG C 3 142 ? 19.68400  0.37400   -18.96100 1.000 32.18880 ? 142 ARG L CA  1 
ATOM   4514 C C   . ARG C 3 142 ? 19.83200  0.13800   -20.46000 1.000 26.08849 ? 142 ARG L C   1 
ATOM   4515 O O   . ARG C 3 142 ? 20.86600  -0.37100  -20.90600 1.000 22.49257 ? 142 ARG L O   1 
ATOM   4516 C CB  . ARG C 3 142 ? 19.12700  -0.87100  -18.26800 1.000 35.90437 ? 142 ARG L CB  1 
ATOM   4517 C CG  . ARG C 3 142 ? 19.93800  -2.14600  -18.42500 1.000 33.03440 ? 142 ARG L CG  1 
ATOM   4518 C CD  . ARG C 3 142 ? 19.26600  -3.27200  -17.64900 1.000 35.49319 ? 142 ARG L CD  1 
ATOM   4519 N NE  . ARG C 3 142 ? 20.20500  -4.28700  -17.18800 1.000 32.74977 ? 142 ARG L NE  1 
ATOM   4520 C CZ  . ARG C 3 142 ? 20.41200  -5.44600  -17.79700 1.000 35.97874 ? 142 ARG L CZ  1 
ATOM   4521 N NH1 . ARG C 3 142 ? 19.77100  -5.76700  -18.90900 1.000 33.78346 ? 142 ARG L NH1 1 
ATOM   4522 N NH2 . ARG C 3 142 ? 21.28100  -6.30700  -17.27600 1.000 40.71308 ? 142 ARG L NH2 1 
ATOM   4523 N N   . GLU C 3 143 ? 18.82700  0.51100   -21.24800 1.000 29.70297 ? 143 GLU L N   1 
ATOM   4524 C CA  . GLU C 3 143 ? 18.84200  0.22600   -22.67700 1.000 30.97265 ? 143 GLU L CA  1 
ATOM   4525 C C   . GLU C 3 143 ? 19.91000  1.04900   -23.38700 1.000 30.70655 ? 143 GLU L C   1 
ATOM   4526 O O   . GLU C 3 143 ? 19.95400  2.27700   -23.26100 1.000 33.87417 ? 143 GLU L O   1 
ATOM   4527 C CB  . GLU C 3 143 ? 17.46900  0.51000   -23.28500 1.000 36.52020 ? 143 GLU L CB  1 
ATOM   4528 C CG  . GLU C 3 143 ? 16.39900  -0.51900  -22.94300 1.000 45.23021 ? 143 GLU L CG  1 
ATOM   4529 C CD  . GLU C 3 143 ? 15.93700  -0.43200  -21.49900 1.000 47.37809 ? 143 GLU L CD  1 
ATOM   4530 O OE1 . GLU C 3 143 ? 15.66500  0.69200   -21.02700 1.000 39.46710 ? 143 GLU L OE1 1 
ATOM   4531 O OE2 . GLU C 3 143 ? 15.84500  -1.48800  -20.83900 1.000 49.28447 ? 143 GLU L OE2 1 
ATOM   4532 N N   . ALA C 3 144 ? 20.76600  0.36900   -24.14600 1.000 25.36062 ? 144 ALA L N   1 
ATOM   4533 C CA  . ALA C 3 144 ? 21.80500  1.02500   -24.92400 1.000 24.79179 ? 144 ALA L CA  1 
ATOM   4534 C C   . ALA C 3 144 ? 22.14200  0.16000   -26.12900 1.000 25.53336 ? 144 ALA L C   1 
ATOM   4535 O O   . ALA C 3 144 ? 22.00900  -1.06600  -26.08800 1.000 33.38387 ? 144 ALA L O   1 
ATOM   4536 C CB  . ALA C 3 144 ? 23.06400  1.28200   -24.08700 1.000 24.79778 ? 144 ALA L CB  1 
ATOM   4537 N N   . LYS C 3 145 ? 22.57700  0.81100   -27.20500 1.000 28.68676 ? 145 LYS L N   1 
ATOM   4538 C CA  . LYS C 3 145 ? 22.99200  0.13200   -28.42700 1.000 30.41629 ? 145 LYS L CA  1 
ATOM   4539 C C   . LYS C 3 145 ? 24.46100  0.43300   -28.67700 1.000 28.44315 ? 145 LYS L C   1 
ATOM   4540 O O   . LYS C 3 145 ? 24.85300  1.60100   -28.76300 1.000 26.03487 ? 145 LYS L O   1 
ATOM   4541 C CB  . LYS C 3 145 ? 22.14400  0.56900   -29.62400 1.000 25.82884 ? 145 LYS L CB  1 
ATOM   4542 C CG  . LYS C 3 145 ? 22.77800  0.24000   -30.97000 1.000 38.94364 ? 145 LYS L CG  1 
ATOM   4543 C CD  . LYS C 3 145 ? 21.72800  -0.01200  -32.04100 1.000 49.82133 ? 145 LYS L CD  1 
ATOM   4544 C CE  . LYS C 3 145 ? 21.22000  1.29200   -32.63500 1.000 57.09947 ? 145 LYS L CE  1 
ATOM   4545 N NZ  . LYS C 3 145 ? 22.28200  2.33500   -32.67200 1.000 56.63591 ? 145 LYS L NZ  1 
ATOM   4546 N N   . VAL C 3 146 ? 25.26700  -0.61900  -28.79600 1.000 26.24898 ? 146 VAL L N   1 
ATOM   4547 C CA  . VAL C 3 146 ? 26.70300  -0.50400  -29.02200 1.000 26.62658 ? 146 VAL L CA  1 
ATOM   4548 C C   . VAL C 3 146 ? 27.03800  -1.26100  -30.29800 1.000 25.00136 ? 146 VAL L C   1 
ATOM   4549 O O   . VAL C 3 146 ? 26.85700  -2.48400  -30.36700 1.000 26.96489 ? 146 VAL L O   1 
ATOM   4550 C CB  . VAL C 3 146 ? 27.51100  -1.04500  -27.83300 1.000 33.13344 ? 146 VAL L CB  1 
ATOM   4551 C CG1 . VAL C 3 146 ? 28.99900  -0.97100  -28.12800 1.000 30.35971 ? 146 VAL L CG1 1 
ATOM   4552 C CG2 . VAL C 3 146 ? 27.17000  -0.27400  -26.56800 1.000 28.74814 ? 146 VAL L CG2 1 
ATOM   4553 N N   . GLN C 3 147 ? 27.52400  -0.54100  -31.30500 1.000 26.19701 ? 147 GLN L N   1 
ATOM   4554 C CA  . GLN C 3 147 ? 27.83900  -1.11700  -32.60500 1.000 34.44085 ? 147 GLN L CA  1 
ATOM   4555 C C   . GLN C 3 147 ? 29.33000  -0.97900  -32.87300 1.000 27.02746 ? 147 GLN L C   1 
ATOM   4556 O O   . GLN C 3 147 ? 29.88900  0.11600   -32.75300 1.000 32.21738 ? 147 GLN L O   1 
ATOM   4557 C CB  . GLN C 3 147 ? 27.03500  -0.44000  -33.71800 1.000 33.98542 ? 147 GLN L CB  1 
ATOM   4558 C CG  . GLN C 3 147 ? 25.67000  -1.06700  -33.95800 1.000 45.62166 ? 147 GLN L CG  1 
ATOM   4559 C CD  . GLN C 3 147 ? 24.90800  -0.39900  -35.08600 1.000 55.69552 ? 147 GLN L CD  1 
ATOM   4560 O OE1 . GLN C 3 147 ? 25.36300  0.59200   -35.65800 1.000 55.54861 ? 147 GLN L OE1 1 
ATOM   4561 N NE2 . GLN C 3 147 ? 23.74200  -0.94200  -35.41500 1.000 51.48878 ? 147 GLN L NE2 1 
ATOM   4562 N N   . TRP C 3 148 ? 29.96700  -2.09000  -33.23100 1.000 28.18331 ? 148 TRP L N   1 
ATOM   4563 C CA  . TRP C 3 148 ? 31.38400  -2.10000  -33.56600 1.000 34.44765 ? 148 TRP L CA  1 
ATOM   4564 C C   . TRP C 3 148 ? 31.56200  -1.79600  -35.04700 1.000 33.47984 ? 148 TRP L C   1 
ATOM   4565 O O   . TRP C 3 148 ? 30.85200  -2.35100  -35.89200 1.000 35.70462 ? 148 TRP L O   1 
ATOM   4566 C CB  . TRP C 3 148 ? 32.01500  -3.45100  -33.22800 1.000 30.94449 ? 148 TRP L CB  1 
ATOM   4567 C CG  . TRP C 3 148 ? 32.31800  -3.62400  -31.77500 1.000 36.79312 ? 148 TRP L CG  1 
ATOM   4568 C CD1 . TRP C 3 148 ? 31.57900  -4.31300  -30.85900 1.000 25.05873 ? 148 TRP L CD1 1 
ATOM   4569 C CD2 . TRP C 3 148 ? 33.44500  -3.09400  -31.06600 1.000 27.95267 ? 148 TRP L CD2 1 
ATOM   4570 N NE1 . TRP C 3 148 ? 32.17700  -4.24700  -29.62300 1.000 26.63707 ? 148 TRP L NE1 1 
ATOM   4571 C CE2 . TRP C 3 148 ? 33.32300  -3.50300  -29.72300 1.000 25.97640 ? 148 TRP L CE2 1 
ATOM   4572 C CE3 . TRP C 3 148 ? 34.54400  -2.31300  -31.43600 1.000 31.63038 ? 148 TRP L CE3 1 
ATOM   4573 C CZ2 . TRP C 3 148 ? 34.25900  -3.15900  -28.75100 1.000 26.90722 ? 148 TRP L CZ2 1 
ATOM   4574 C CZ3 . TRP C 3 148 ? 35.47100  -1.97200  -30.46900 1.000 32.39210 ? 148 TRP L CZ3 1 
ATOM   4575 C CH2 . TRP C 3 148 ? 35.32300  -2.39500  -29.14200 1.000 25.14698 ? 148 TRP L CH2 1 
ATOM   4576 N N   . LYS C 3 149 ? 32.51100  -0.91600  -35.35700 1.000 32.61589 ? 149 LYS L N   1 
ATOM   4577 C CA  . LYS C 3 149 ? 32.82000  -0.54900  -36.73300 1.000 39.86458 ? 149 LYS L CA  1 
ATOM   4578 C C   . LYS C 3 149 ? 34.30200  -0.77600  -36.97900 1.000 36.24415 ? 149 LYS L C   1 
ATOM   4579 O O   . LYS C 3 149 ? 35.14600  -0.14700  -36.33100 1.000 37.15037 ? 149 LYS L O   1 
ATOM   4580 C CB  . LYS C 3 149 ? 32.43700  0.90500   -37.02100 1.000 31.27967 ? 149 LYS L CB  1 
ATOM   4581 C CG  . LYS C 3 149 ? 31.11600  1.04800   -37.75800 1.000 33.78278 ? 149 LYS L CG  1 
ATOM   4582 C CD  . LYS C 3 149 ? 30.33500  2.25700   -37.28100 1.000 44.51756 ? 149 LYS L CD  1 
ATOM   4583 C CE  . LYS C 3 149 ? 28.84300  2.04300   -37.46200 1.000 47.56073 ? 149 LYS L CE  1 
ATOM   4584 N NZ  . LYS C 3 149 ? 28.07900  3.30900   -37.32400 1.000 55.21771 ? 149 LYS L NZ  1 
ATOM   4585 N N   . VAL C 3 150 ? 34.61300  -1.67200  -37.90800 1.000 38.36039 ? 150 VAL L N   1 
ATOM   4586 C CA  . VAL C 3 150 ? 35.98400  -2.01300  -38.26600 1.000 41.69609 ? 150 VAL L CA  1 
ATOM   4587 C C   . VAL C 3 150 ? 36.20100  -1.56800  -39.70500 1.000 46.74322 ? 150 VAL L C   1 
ATOM   4588 O O   . VAL C 3 150 ? 35.62700  -2.14800  -40.63600 1.000 49.30603 ? 150 VAL L O   1 
ATOM   4589 C CB  . VAL C 3 150 ? 36.26000  -3.51300  -38.09300 1.000 41.24791 ? 150 VAL L CB  1 
ATOM   4590 C CG1 . VAL C 3 150 ? 37.61600  -3.86800  -38.65700 1.000 38.97726 ? 150 VAL L CG1 1 
ATOM   4591 C CG2 . VAL C 3 150 ? 36.17900  -3.89500  -36.62500 1.000 37.29462 ? 150 VAL L CG2 1 
ATOM   4592 N N   . ASP C 3 151 ? 37.03200  -0.53900  -39.88700 1.000 50.77087 ? 151 ASP L N   1 
ATOM   4593 C CA  . ASP C 3 151 ? 37.23800  0.08800   -41.19400 1.000 49.80819 ? 151 ASP L CA  1 
ATOM   4594 C C   . ASP C 3 151 ? 35.90500  0.49800   -41.81500 1.000 52.89598 ? 151 ASP L C   1 
ATOM   4595 O O   . ASP C 3 151 ? 35.64900  0.27100   -43.00000 1.000 56.15708 ? 151 ASP L O   1 
ATOM   4596 C CB  . ASP C 3 151 ? 38.02500  -0.82800  -42.13400 1.000 54.01954 ? 151 ASP L CB  1 
ATOM   4597 C CG  . ASP C 3 151 ? 39.52100  -0.77300  -41.88600 1.000 53.06196 ? 151 ASP L CG  1 
ATOM   4598 O OD1 . ASP C 3 151 ? 39.98900  0.21000   -41.27200 1.000 39.66686 ? 151 ASP L OD1 1 
ATOM   4599 O OD2 . ASP C 3 151 ? 40.23000  -1.71000  -42.30900 1.000 51.24693 ? 151 ASP L OD2 1 
ATOM   4600 N N   . ASN C 3 152 ? 35.04700  1.10700   -40.99300 1.000 51.38388 ? 152 ASN L N   1 
ATOM   4601 C CA  . ASN C 3 152 ? 33.71900  1.56500   -41.40900 1.000 51.54592 ? 152 ASN L CA  1 
ATOM   4602 C C   . ASN C 3 152 ? 32.88400  0.41600   -41.97300 1.000 51.85492 ? 152 ASN L C   1 
ATOM   4603 O O   . ASN C 3 152 ? 32.24700  0.53100   -43.02200 1.000 71.53438 ? 152 ASN L O   1 
ATOM   4604 C CB  . ASN C 3 152 ? 33.82200  2.71900   -42.41000 1.000 47.39147 ? 152 ASN L CB  1 
ATOM   4605 C CG  . ASN C 3 152 ? 34.90600  3.71200   -42.04400 1.000 63.69112 ? 152 ASN L CG  1 
ATOM   4606 O OD1 . ASN C 3 152 ? 36.06300  3.56100   -42.43600 1.000 68.42902 ? 152 ASN L OD1 1 
ATOM   4607 N ND2 . ASN C 3 152 ? 34.53700  4.73600   -41.28300 1.000 74.61338 ? 152 ASN L ND2 1 
ATOM   4608 N N   . ALA C 3 153 ? 32.89100  -0.70700  -41.25800 1.000 39.46321 ? 153 ALA L N   1 
ATOM   4609 C CA  . ALA C 3 153 ? 32.07500  -1.86400  -41.60900 1.000 46.15008 ? 153 ALA L CA  1 
ATOM   4610 C C   . ALA C 3 153 ? 31.43000  -2.39400  -40.34000 1.000 49.35298 ? 153 ALA L C   1 
ATOM   4611 O O   . ALA C 3 153 ? 32.13400  -2.77300  -39.39800 1.000 42.11286 ? 153 ALA L O   1 
ATOM   4612 C CB  . ALA C 3 153 ? 32.90900  -2.95300  -42.29000 1.000 47.33108 ? 153 ALA L CB  1 
ATOM   4613 N N   . LEU C 3 154 ? 30.09900  -2.41600  -40.31400 1.000 45.06151 ? 154 LEU L N   1 
ATOM   4614 C CA  . LEU C 3 154 ? 29.37200  -2.85600  -39.13000 1.000 39.75669 ? 154 LEU L CA  1 
ATOM   4615 C C   . LEU C 3 154 ? 29.65900  -4.32300  -38.83800 1.000 43.27910 ? 154 LEU L C   1 
ATOM   4616 O O   . LEU C 3 154 ? 29.45800  -5.18800  -39.69600 1.000 44.76125 ? 154 LEU L O   1 
ATOM   4617 C CB  . LEU C 3 154 ? 27.87300  -2.63300  -39.32400 1.000 36.56782 ? 154 LEU L CB  1 
ATOM   4618 C CG  . LEU C 3 154 ? 26.97200  -3.13100  -38.19200 1.000 52.04198 ? 154 LEU L CG  1 
ATOM   4619 C CD1 . LEU C 3 154 ? 27.32300  -2.43700  -36.88400 1.000 47.25990 ? 154 LEU L CD1 1 
ATOM   4620 C CD2 . LEU C 3 154 ? 25.50600  -2.92100  -38.54000 1.000 43.09376 ? 154 LEU L CD2 1 
ATOM   4621 N N   . GLN C 3 155 ? 30.12400  -4.59800  -37.62400 1.000 42.58413 ? 155 GLN L N   1 
ATOM   4622 C CA  . GLN C 3 155 ? 30.47500  -5.94900  -37.21700 1.000 37.40368 ? 155 GLN L CA  1 
ATOM   4623 C C   . GLN C 3 155 ? 29.28400  -6.65200  -36.57600 1.000 40.33314 ? 155 GLN L C   1 
ATOM   4624 O O   . GLN C 3 155 ? 28.34900  -6.02200  -36.07600 1.000 43.48071 ? 155 GLN L O   1 
ATOM   4625 C CB  . GLN C 3 155 ? 31.65000  -5.92900  -36.24000 1.000 38.32130 ? 155 GLN L CB  1 
ATOM   4626 C CG  . GLN C 3 155 ? 32.93000  -5.36700  -36.82200 1.000 36.30952 ? 155 GLN L CG  1 
ATOM   4627 C CD  . GLN C 3 155 ? 33.38400  -6.11500  -38.05800 1.000 45.54848 ? 155 GLN L CD  1 
ATOM   4628 O OE1 . GLN C 3 155 ? 33.70100  -7.30300  -37.99800 1.000 39.64086 ? 155 GLN L OE1 1 
ATOM   4629 N NE2 . GLN C 3 155 ? 33.41800  -5.42200  -39.19000 1.000 50.18204 ? 155 GLN L NE2 1 
ATOM   4630 N N   . SER C 3 156 ? 29.33500  -7.98200  -36.59600 1.000 42.57828 ? 156 SER L N   1 
ATOM   4631 C CA  . SER C 3 156 ? 28.32700  -8.80400  -35.94400 1.000 36.25843 ? 156 SER L CA  1 
ATOM   4632 C C   . SER C 3 156 ? 28.92100  -10.18000 -35.68800 1.000 35.31912 ? 156 SER L C   1 
ATOM   4633 O O   . SER C 3 156 ? 29.83000  -10.61900 -36.39700 1.000 36.35059 ? 156 SER L O   1 
ATOM   4634 C CB  . SER C 3 156 ? 27.05100  -8.91400  -36.78800 1.000 45.04650 ? 156 SER L CB  1 
ATOM   4635 O OG  . SER C 3 156 ? 27.24100  -9.77300  -37.89900 1.000 45.47608 ? 156 SER L OG  1 
ATOM   4636 N N   . GLY C 3 157 ? 28.40800  -10.84600 -34.65400 1.000 31.32299 ? 157 GLY L N   1 
ATOM   4637 C CA  . GLY C 3 157 ? 28.80600  -12.20300 -34.34000 1.000 26.37664 ? 157 GLY L CA  1 
ATOM   4638 C C   . GLY C 3 157 ? 30.17700  -12.36700 -33.72300 1.000 34.52913 ? 157 GLY L C   1 
ATOM   4639 O O   . GLY C 3 157 ? 30.57900  -13.50500 -33.45300 1.000 39.61880 ? 157 GLY L O   1 
ATOM   4640 N N   . ASN C 3 158 ? 30.91400  -11.27800 -33.48500 1.000 33.39722 ? 158 ASN L N   1 
ATOM   4641 C CA  . ASN C 3 158 ? 32.25400  -11.37200 -32.91700 1.000 31.95941 ? 158 ASN L CA  1 
ATOM   4642 C C   . ASN C 3 158 ? 32.42000  -10.48500 -31.68600 1.000 28.36706 ? 158 ASN L C   1 
ATOM   4643 O O   . ASN C 3 158 ? 33.55100  -10.16300 -31.31000 1.000 28.02307 ? 158 ASN L O   1 
ATOM   4644 C CB  . ASN C 3 158 ? 33.31300  -11.02100 -33.96600 1.000 36.27829 ? 158 ASN L CB  1 
ATOM   4645 C CG  . ASN C 3 158 ? 32.98400  -9.75100  -34.72400 1.000 34.33160 ? 158 ASN L CG  1 
ATOM   4646 O OD1 . ASN C 3 158 ? 31.96000  -9.11300  -34.47500 1.000 32.51894 ? 158 ASN L OD1 1 
ATOM   4647 N ND2 . ASN C 3 158 ? 33.85400  -9.37400  -35.65300 1.000 36.89166 ? 158 ASN L ND2 1 
ATOM   4648 N N   . SER C 3 159 ? 31.30500  -10.10900 -31.07300 1.000 28.01010 ? 159 SER L N   1 
ATOM   4649 C CA  . SER C 3 159 ? 31.31100  -9.28300  -29.88100 1.000 26.25233 ? 159 SER L CA  1 
ATOM   4650 C C   . SER C 3 159 ? 30.45400  -9.87300  -28.78300 1.000 27.59528 ? 159 SER L C   1 
ATOM   4651 O O   . SER C 3 159 ? 29.50700  -10.58400 -29.04500 1.000 27.52035 ? 159 SER L O   1 
ATOM   4652 C CB  . SER C 3 159 ? 30.80800  -7.85700  -30.19300 1.000 24.75986 ? 159 SER L CB  1 
ATOM   4653 O OG  . SER C 3 159 ? 29.40500  -7.76000  -30.16600 1.000 33.12950 ? 159 SER L OG  1 
ATOM   4654 N N   . GLN C 3 160 ? 30.79200  -9.56700  -27.54900 1.000 28.68819 ? 160 GLN L N   1 
ATOM   4655 C CA  . GLN C 3 160 ? 29.98900  -9.99800  -26.42300 1.000 22.50794 ? 160 GLN L CA  1 
ATOM   4656 C C   . GLN C 3 160 ? 29.84500  -8.85900  -25.42100 1.000 24.15479 ? 160 GLN L C   1 
ATOM   4657 O O   . GLN C 3 160 ? 30.78900  -8.14100  -25.15600 1.000 21.48309 ? 160 GLN L O   1 
ATOM   4658 C CB  . GLN C 3 160 ? 30.58200  -11.22600 -25.76800 1.000 27.59060 ? 160 GLN L CB  1 
ATOM   4659 C CG  . GLN C 3 160 ? 30.41000  -12.53200 -26.51700 1.000 27.51172 ? 160 GLN L CG  1 
ATOM   4660 C CD  . GLN C 3 160 ? 30.81200  -13.72700 -25.67300 1.000 31.76393 ? 160 GLN L CD  1 
ATOM   4661 O OE1 . GLN C 3 160 ? 31.97900  -13.90900 -25.35900 1.000 29.81826 ? 160 GLN L OE1 1 
ATOM   4662 N NE2 . GLN C 3 160 ? 29.83800  -14.53800 -25.29800 1.000 25.98811 ? 160 GLN L NE2 1 
ATOM   4663 N N   . GLU C 3 161 ? 28.65700  -8.69000  -24.88800 1.000 23.90847 ? 161 GLU L N   1 
ATOM   4664 C CA  . GLU C 3 161 ? 28.38800  -7.63300  -23.92900 1.000 22.77925 ? 161 GLU L CA  1 
ATOM   4665 C C   . GLU C 3 161 ? 28.08100  -8.09300  -22.50600 1.000 21.88866 ? 161 GLU L C   1 
ATOM   4666 O O   . GLU C 3 161 ? 27.51100  -9.15600  -22.31900 1.000 21.85052 ? 161 GLU L O   1 
ATOM   4667 C CB  . GLU C 3 161 ? 27.18800  -6.81900  -24.40600 1.000 24.83215 ? 161 GLU L CB  1 
ATOM   4668 C CG  . GLU C 3 161 ? 27.34700  -6.04900  -25.70000 1.000 27.13461 ? 161 GLU L CG  1 
ATOM   4669 C CD  . GLU C 3 161 ? 26.16200  -5.13800  -25.97300 1.000 26.76079 ? 161 GLU L CD  1 
ATOM   4670 O OE1 . GLU C 3 161 ? 25.14600  -5.22400  -25.26400 1.000 23.86667 ? 161 GLU L OE1 1 
ATOM   4671 O OE2 . GLU C 3 161 ? 26.24900  -4.32900  -26.90300 1.000 31.49957 ? 161 GLU L OE2 1 
ATOM   4672 N N   . SER C 3 162 ? 28.45600  -7.29800  -21.52000 1.000 15.29355 ? 162 SER L N   1 
ATOM   4673 C CA  . SER C 3 162 ? 28.12300  -7.59500  -20.13000 1.000 18.65150 ? 162 SER L CA  1 
ATOM   4674 C C   . SER C 3 162 ? 27.63900  -6.33400  -19.46300 1.000 18.87746 ? 162 SER L C   1 
ATOM   4675 O O   . SER C 3 162 ? 28.15200  -5.26000  -19.72100 1.000 19.99078 ? 162 SER L O   1 
ATOM   4676 C CB  . SER C 3 162 ? 29.26800  -8.22800  -19.31000 1.000 19.70933 ? 162 SER L CB  1 
ATOM   4677 O OG  . SER C 3 162 ? 28.94900  -8.33000  -17.94900 1.000 20.44658 ? 162 SER L OG  1 
ATOM   4678 N N   . VAL C 3 163 ? 26.64300  -6.48300  -18.61900 1.000 18.96572 ? 163 VAL L N   1 
ATOM   4679 C CA  . VAL C 3 163 ? 26.08300  -5.35400  -17.93000 1.000 20.29092 ? 163 VAL L CA  1 
ATOM   4680 C C   . VAL C 3 163 ? 26.06700  -5.51800  -16.41100 1.000 20.43873 ? 163 VAL L C   1 
ATOM   4681 O O   . VAL C 3 163 ? 25.67900  -6.53900  -15.90600 1.000 21.97104 ? 163 VAL L O   1 
ATOM   4682 C CB  . VAL C 3 163 ? 24.66600  -5.02400  -18.43000 1.000 22.59219 ? 163 VAL L CB  1 
ATOM   4683 C CG1 . VAL C 3 163 ? 24.15000  -3.75400  -17.77900 1.000 21.96234 ? 163 VAL L CG1 1 
ATOM   4684 C CG2 . VAL C 3 163 ? 24.64300  -4.90100  -19.94000 1.000 29.34056 ? 163 VAL L CG2 1 
ATOM   4685 N N   . THR C 3 164 ? 26.49800  -4.49100  -15.70900 1.000 19.18510 ? 164 THR L N   1 
ATOM   4686 C CA  . THR C 3 164 ? 26.49000  -4.50300  -14.27200 1.000 16.93881 ? 164 THR L CA  1 
ATOM   4687 C C   . THR C 3 164 ? 25.11600  -4.40200  -13.69400 1.000 22.00915 ? 164 THR L C   1 
ATOM   4688 O O   . THR C 3 164 ? 24.20500  -3.91800  -14.34200 1.000 23.92704 ? 164 THR L O   1 
ATOM   4689 C CB  . THR C 3 164 ? 27.29300  -3.30000  -13.70400 1.000 17.75209 ? 164 THR L CB  1 
ATOM   4690 O OG1 . THR C 3 164 ? 26.83400  -2.09000  -14.29700 1.000 22.08926 ? 164 THR L OG1 1 
ATOM   4691 C CG2 . THR C 3 164 ? 28.77400  -3.47300  -13.97700 1.000 18.64786 ? 164 THR L CG2 1 
ATOM   4692 N N   . GLU C 3 165 ? 24.96700  -4.85700  -12.47200 1.000 20.37335 ? 165 GLU L N   1 
ATOM   4693 C CA  . GLU C 3 165 ? 23.73400  -4.68300  -11.77000 1.000 20.99208 ? 165 GLU L CA  1 
ATOM   4694 C C   . GLU C 3 165 ? 23.62800  -3.20200  -11.37200 1.000 19.66340 ? 165 GLU L C   1 
ATOM   4695 O O   . GLU C 3 165 ? 24.62100  -2.53200  -11.32800 1.000 19.75727 ? 165 GLU L O   1 
ATOM   4696 C CB  . GLU C 3 165 ? 23.73300  -5.54400  -10.53200 1.000 29.12497 ? 165 GLU L CB  1 
ATOM   4697 C CG  . GLU C 3 165 ? 23.89000  -7.03200  -10.74600 1.000 36.00374 ? 165 GLU L CG  1 
ATOM   4698 C CD  . GLU C 3 165 ? 22.56300  -7.75300  -10.74900 1.000 36.82954 ? 165 GLU L CD  1 
ATOM   4699 O OE1 . GLU C 3 165 ? 21.52500  -7.10000  -10.95000 1.000 43.51425 ? 165 GLU L OE1 1 
ATOM   4700 O OE2 . GLU C 3 165 ? 22.56300  -8.97700  -10.55800 1.000 52.69591 ? 165 GLU L OE2 1 
ATOM   4701 N N   . GLN C 3 166 ? 22.44500  -2.72700  -11.06400 1.000 17.40920 ? 166 GLN L N   1 
ATOM   4702 C CA  . GLN C 3 166 ? 22.23500  -1.32100  -10.74200 1.000 22.49474 ? 166 GLN L CA  1 
ATOM   4703 C C   . GLN C 3 166 ? 23.10800  -0.90700  -9.56400  1.000 24.35130 ? 166 GLN L C   1 
ATOM   4704 O O   . GLN C 3 166 ? 23.18900  -1.61200  -8.55400  1.000 19.35356 ? 166 GLN L O   1 
ATOM   4705 C CB  . GLN C 3 166 ? 20.76200  -1.06300  -10.42800 1.000 18.94569 ? 166 GLN L CB  1 
ATOM   4706 C CG  . GLN C 3 166 ? 20.39300  0.41100   -10.39600 1.000 22.68820 ? 166 GLN L CG  1 
ATOM   4707 C CD  . GLN C 3 166 ? 18.89600  0.64100   -10.38900 1.000 28.80955 ? 166 GLN L CD  1 
ATOM   4708 O OE1 . GLN C 3 166 ? 18.14900  -0.07600  -9.72100  1.000 30.82980 ? 166 GLN L OE1 1 
ATOM   4709 N NE2 . GLN C 3 166 ? 18.44800  1.64600   -11.13300 1.000 18.78636 ? 166 GLN L NE2 1 
ATOM   4710 N N   . ASP C 3 167 ? 23.77400  0.23600   -9.70500  1.000 21.21278 ? 167 ASP L N   1 
ATOM   4711 C CA  . ASP C 3 167 ? 24.63800  0.73300   -8.64400  1.000 19.23110 ? 167 ASP L CA  1 
ATOM   4712 C C   . ASP C 3 167 ? 23.80500  1.12700   -7.43000  1.000 18.22777 ? 167 ASP L C   1 
ATOM   4713 O O   . ASP C 3 167 ? 22.75300  1.75800   -7.55500  1.000 22.33021 ? 167 ASP L O   1 
ATOM   4714 C CB  . ASP C 3 167 ? 25.45300  1.92500   -9.14200  1.000 20.17715 ? 167 ASP L CB  1 
ATOM   4715 C CG  . ASP C 3 167 ? 26.48600  2.38700   -8.13400  1.000 23.19755 ? 167 ASP L CG  1 
ATOM   4716 O OD1 . ASP C 3 167 ? 26.14400  3.22200   -7.27200  1.000 25.01308 ? 167 ASP L OD1 1 
ATOM   4717 O OD2 . ASP C 3 167 ? 27.64100  1.91700   -8.20600  1.000 19.60465 ? 167 ASP L OD2 1 
ATOM   4718 N N   . SER C 3 168 ? 24.27900  0.74400   -6.24700  1.000 17.37095 ? 168 SER L N   1 
ATOM   4719 C CA  . SER C 3 168 ? 23.53200  0.99600   -5.02200  1.000 21.98442 ? 168 SER L CA  1 
ATOM   4720 C C   . SER C 3 168 ? 23.59200  2.44900   -4.56700  1.000 21.05391 ? 168 SER L C   1 
ATOM   4721 O O   . SER C 3 168 ? 22.90100  2.80500   -3.60700  1.000 19.41491 ? 168 SER L O   1 
ATOM   4722 C CB  . SER C 3 168 ? 24.04200  0.09000   -3.89800  1.000 16.36682 ? 168 SER L CB  1 
ATOM   4723 O OG  . SER C 3 168 ? 25.42300  0.30300   -3.66000  1.000 26.36624 ? 168 SER L OG  1 
ATOM   4724 N N   . LYS C 3 169 ? 24.39900  3.28500   -5.20100  1.000 16.14305 ? 169 LYS L N   1 
ATOM   4725 C CA  . LYS C 3 169 ? 24.52000  4.68300   -4.82700  1.000 21.46253 ? 169 LYS L CA  1 
ATOM   4726 C C   . LYS C 3 169 ? 23.92200  5.66500   -5.85800  1.000 21.14828 ? 169 LYS L C   1 
ATOM   4727 O O   . LYS C 3 169 ? 23.10400  6.47700   -5.49400  1.000 21.38790 ? 169 LYS L O   1 
ATOM   4728 C CB  . LYS C 3 169 ? 25.97100  5.02400   -4.53600  1.000 25.42488 ? 169 LYS L CB  1 
ATOM   4729 C CG  . LYS C 3 169 ? 26.45700  4.52600   -3.19500  1.000 28.93012 ? 169 LYS L CG  1 
ATOM   4730 C CD  . LYS C 3 169 ? 27.95700  4.29600   -3.19900  1.000 38.20250 ? 169 LYS L CD  1 
ATOM   4731 C CE  . LYS C 3 169 ? 28.72900  5.57300   -3.46900  1.000 45.11915 ? 169 LYS L CE  1 
ATOM   4732 N NZ  . LYS C 3 169 ? 30.19400  5.34600   -3.31700  1.000 49.55681 ? 169 LYS L NZ  1 
ATOM   4733 N N   . ASP C 3 170 ? 24.32000  5.56800   -7.11800  1.000 15.04992 ? 170 ASP L N   1 
ATOM   4734 C CA  . ASP C 3 170 ? 23.80300  6.47600   -8.13500  1.000 20.38890 ? 170 ASP L CA  1 
ATOM   4735 C C   . ASP C 3 170 ? 22.75900  5.83600   -9.04400  1.000 22.44809 ? 170 ASP L C   1 
ATOM   4736 O O   . ASP C 3 170 ? 22.25900  6.50500   -9.95500  1.000 21.39791 ? 170 ASP L O   1 
ATOM   4737 C CB  . ASP C 3 170 ? 24.95500  7.06600   -8.97000  1.000 22.16092 ? 170 ASP L CB  1 
ATOM   4738 C CG  . ASP C 3 170 ? 25.68900  6.02900   -9.82100  1.000 22.55368 ? 170 ASP L CG  1 
ATOM   4739 O OD1 . ASP C 3 170 ? 25.13600  4.95400   -10.13200 1.000 22.37801 ? 170 ASP L OD1 1 
ATOM   4740 O OD2 . ASP C 3 170 ? 26.84900  6.30600   -10.19100 1.000 27.28617 ? 170 ASP L OD2 1 
ATOM   4741 N N   . SER C 3 171 ? 22.43500  4.56000   -8.82900  1.000 17.05419 ? 171 SER L N   1 
ATOM   4742 C CA  . SER C 3 171 ? 21.35300  3.86400   -9.52400  1.000 18.31020 ? 171 SER L CA  1 
ATOM   4743 C C   . SER C 3 171 ? 21.57200  3.77300   -11.03200 1.000 17.80056 ? 171 SER L C   1 
ATOM   4744 O O   . SER C 3 171 ? 20.61200  3.59800   -11.78900 1.000 24.79389 ? 171 SER L O   1 
ATOM   4745 C CB  . SER C 3 171 ? 19.99700  4.52000   -9.23200  1.000 22.02424 ? 171 SER L CB  1 
ATOM   4746 O OG  . SER C 3 171 ? 19.78300  4.64300   -7.83600  1.000 19.17854 ? 171 SER L OG  1 
ATOM   4747 N N   . THR C 3 172 ? 22.81400  3.87800   -11.49400 1.000 19.67083 ? 172 THR L N   1 
ATOM   4748 C CA  . THR C 3 172 ? 23.11900  3.76200   -12.90900 1.000 21.02364 ? 172 THR L CA  1 
ATOM   4749 C C   . THR C 3 172 ? 23.55000  2.33500   -13.24000 1.000 24.56216 ? 172 THR L C   1 
ATOM   4750 O O   . THR C 3 172 ? 23.66500  1.46800   -12.37000 1.000 20.97615 ? 172 THR L O   1 
ATOM   4751 C CB  . THR C 3 172 ? 24.20900  4.75500   -13.32000 1.000 21.81898 ? 172 THR L CB  1 
ATOM   4752 O OG1 . THR C 3 172 ? 25.43300  4.43500   -12.64500 1.000 18.02596 ? 172 THR L OG1 1 
ATOM   4753 C CG2 . THR C 3 172 ? 23.79700  6.17800   -12.98200 1.000 18.75529 ? 172 THR L CG2 1 
ATOM   4754 N N   . TYR C 3 173 ? 23.85500  2.14100   -14.50500 1.000 17.62420 ? 173 TYR L N   1 
ATOM   4755 C CA  . TYR C 3 173 ? 24.33700  0.88600   -14.95600 1.000 21.19837 ? 173 TYR L CA  1 
ATOM   4756 C C   . TYR C 3 173 ? 25.59500  1.14200   -15.75300 1.000 22.26859 ? 173 TYR L C   1 
ATOM   4757 O O   . TYR C 3 173 ? 25.79900  2.22300   -16.26200 1.000 18.37186 ? 173 TYR L O   1 
ATOM   4758 C CB  . TYR C 3 173 ? 23.33000  0.19600   -15.87100 1.000 21.57439 ? 173 TYR L CB  1 
ATOM   4759 C CG  . TYR C 3 173 ? 21.99500  -0.12000  -15.25900 1.000 24.26918 ? 173 TYR L CG  1 
ATOM   4760 C CD1 . TYR C 3 173 ? 20.95600  0.78600   -15.33000 1.000 23.20980 ? 173 TYR L CD1 1 
ATOM   4761 C CD2 . TYR C 3 173 ? 21.76600  -1.33200  -14.63100 1.000 22.02642 ? 173 TYR L CD2 1 
ATOM   4762 C CE1 . TYR C 3 173 ? 19.72700  0.50500   -14.77800 1.000 29.76523 ? 173 TYR L CE1 1 
ATOM   4763 C CE2 . TYR C 3 173 ? 20.54000  -1.62500  -14.07900 1.000 26.61490 ? 173 TYR L CE2 1 
ATOM   4764 C CZ  . TYR C 3 173 ? 19.52400  -0.70000  -14.15700 1.000 27.85040 ? 173 TYR L CZ  1 
ATOM   4765 O OH  . TYR C 3 173 ? 18.30100  -0.96700  -13.61300 1.000 30.58965 ? 173 TYR L OH  1 
ATOM   4766 N N   . SER C 3 174 ? 26.43700  0.14900   -15.83600 1.000 16.11319 ? 174 SER L N   1 
ATOM   4767 C CA  . SER C 3 174 ? 27.60300  0.26100   -16.65800 1.000 17.04650 ? 174 SER L CA  1 
ATOM   4768 C C   . SER C 3 174 ? 27.65800  -0.96200  -17.61600 1.000 23.15440 ? 174 SER L C   1 
ATOM   4769 O O   . SER C 3 174 ? 27.08900  -2.00700  -17.33200 1.000 18.86453 ? 174 SER L O   1 
ATOM   4770 C CB  . SER C 3 174 ? 28.86600  0.46500   -15.81000 1.000 19.41709 ? 174 SER L CB  1 
ATOM   4771 O OG  . SER C 3 174 ? 28.86800  1.68100   -15.11000 1.000 22.87866 ? 174 SER L OG  1 
ATOM   4772 N N   . LEU C 3 175 ? 28.29200  -0.79300  -18.76600 1.000 22.19453 ? 175 LEU L N   1 
ATOM   4773 C CA  . LEU C 3 175 ? 28.34900  -1.85800  -19.77500 1.000 20.64843 ? 175 LEU L CA  1 
ATOM   4774 C C   . LEU C 3 175 ? 29.67200  -2.03700  -20.49400 1.000 19.37650 ? 175 LEU L C   1 
ATOM   4775 O O   . LEU C 3 175 ? 30.38100  -1.08000  -20.72100 1.000 21.94297 ? 175 LEU L O   1 
ATOM   4776 C CB  . LEU C 3 175 ? 27.22900  -1.67800  -20.82900 1.000 15.30245 ? 175 LEU L CB  1 
ATOM   4777 C CG  . LEU C 3 175 ? 27.07000  -2.64400  -22.00200 1.000 17.32208 ? 175 LEU L CG  1 
ATOM   4778 C CD1 . LEU C 3 175 ? 25.62900  -2.68300  -22.47400 1.000 23.09749 ? 175 LEU L CD1 1 
ATOM   4779 C CD2 . LEU C 3 175 ? 27.99400  -2.30600  -23.15300 1.000 17.02797 ? 175 LEU L CD2 1 
ATOM   4780 N N   . SER C 3 176 ? 29.98400  -3.26600  -20.84000 1.000 19.31145 ? 176 SER L N   1 
ATOM   4781 C CA  . SER C 3 176 ? 31.17600  -3.57700  -21.62300 1.000 19.26956 ? 176 SER L CA  1 
ATOM   4782 C C   . SER C 3 176 ? 30.84500  -4.30100  -22.92500 1.000 21.75691 ? 176 SER L C   1 
ATOM   4783 O O   . SER C 3 176 ? 30.04200  -5.20600  -22.90900 1.000 20.20062 ? 176 SER L O   1 
ATOM   4784 C CB  . SER C 3 176 ? 32.12500  -4.48700  -20.85100 1.000 18.00041 ? 176 SER L CB  1 
ATOM   4785 O OG  . SER C 3 176 ? 31.61600  -5.78700  -20.73400 1.000 25.72356 ? 176 SER L OG  1 
ATOM   4786 N N   . SER C 3 177 ? 31.42200  -3.88400  -24.03900 1.000 19.77492 ? 177 SER L N   1 
ATOM   4787 C CA  . SER C 3 177 ? 31.30300  -4.62300  -25.29900 1.000 25.43831 ? 177 SER L CA  1 
ATOM   4788 C C   . SER C 3 177 ? 32.71500  -5.02200  -25.65100 1.000 26.97358 ? 177 SER L C   1 
ATOM   4789 O O   . SER C 3 177 ? 33.59000  -4.18100  -25.76700 1.000 26.25180 ? 177 SER L O   1 
ATOM   4790 C CB  . SER C 3 177 ? 30.67200  -3.87100  -26.47200 1.000 21.06043 ? 177 SER L CB  1 
ATOM   4791 O OG  . SER C 3 177 ? 30.48500  -4.69700  -27.59100 1.000 26.40334 ? 177 SER L OG  1 
ATOM   4792 N N   . THR C 3 178 ? 32.92500  -6.30200  -25.82600 1.000 24.69469 ? 178 THR L N   1 
ATOM   4793 C CA  . THR C 3 178 ? 34.23700  -6.78400  -26.13400 1.000 23.77982 ? 178 THR L CA  1 
ATOM   4794 C C   . THR C 3 178 ? 34.31500  -7.45800  -27.51200 1.000 33.66125 ? 178 THR L C   1 
ATOM   4795 O O   . THR C 3 178 ? 33.66700  -8.45800  -27.75000 1.000 30.51711 ? 178 THR L O   1 
ATOM   4796 C CB  . THR C 3 178 ? 34.73100  -7.73400  -25.02500 1.000 27.84851 ? 178 THR L CB  1 
ATOM   4797 O OG1 . THR C 3 178 ? 34.65000  -7.09000  -23.75100 1.000 25.64489 ? 178 THR L OG1 1 
ATOM   4798 C CG2 . THR C 3 178 ? 36.16200  -8.16900  -25.28900 1.000 30.59236 ? 178 THR L CG2 1 
ATOM   4799 N N   . LEU C 3 179 ? 35.08800  -6.88500  -28.41500 1.000 27.81525 ? 179 LEU L N   1 
ATOM   4800 C CA  . LEU C 3 179 ? 35.29300  -7.48600  -29.72600 1.000 26.96903 ? 179 LEU L CA  1 
ATOM   4801 C C   . LEU C 3 179 ? 36.51000  -8.38600  -29.68500 1.000 28.93875 ? 179 LEU L C   1 
ATOM   4802 O O   . LEU C 3 179 ? 37.60300  -7.95900  -29.36000 1.000 32.81311 ? 179 LEU L O   1 
ATOM   4803 C CB  . LEU C 3 179 ? 35.41700  -6.43300  -30.82300 1.000 29.02148 ? 179 LEU L CB  1 
ATOM   4804 C CG  . LEU C 3 179 ? 35.58000  -6.82300  -32.28800 1.000 32.96670 ? 179 LEU L CG  1 
ATOM   4805 C CD1 . LEU C 3 179 ? 34.28800  -7.40300  -32.82600 1.000 32.64393 ? 179 LEU L CD1 1 
ATOM   4806 C CD2 . LEU C 3 179 ? 35.97100  -5.59500  -33.08600 1.000 33.81085 ? 179 LEU L CD2 1 
ATOM   4807 N N   . THR C 3 180 ? 36.31100  -9.62500  -30.01300 1.000 25.17868 ? 180 THR L N   1 
ATOM   4808 C CA  . THR C 3 180 ? 37.37900  -10.61600 -29.97100 1.000 37.96037 ? 180 THR L CA  1 
ATOM   4809 C C   . THR C 3 180 ? 37.73700  -11.02600 -31.39200 1.000 36.90056 ? 180 THR L C   1 
ATOM   4810 O O   . THR C 3 180 ? 36.87000  -11.47000 -32.15200 1.000 38.18705 ? 180 THR L O   1 
ATOM   4811 C CB  . THR C 3 180 ? 36.96800  -11.83900 -29.15100 1.000 35.99137 ? 180 THR L CB  1 
ATOM   4812 O OG1 . THR C 3 180 ? 36.44400  -11.41300 -27.88700 1.000 40.91778 ? 180 THR L OG1 1 
ATOM   4813 C CG2 . THR C 3 180 ? 38.16700  -12.74700 -28.91800 1.000 40.08993 ? 180 THR L CG2 1 
ATOM   4814 N N   . LEU C 3 181 ? 39.01300  -10.88100 -31.74300 1.000 35.87410 ? 181 LEU L N   1 
ATOM   4815 C CA  . LEU C 3 181 ? 39.50800  -11.24600 -33.06000 1.000 40.15754 ? 181 LEU L CA  1 
ATOM   4816 C C   . LEU C 3 181 ? 40.85600  -11.93500 -32.91700 1.000 44.48972 ? 181 LEU L C   1 
ATOM   4817 O O   . LEU C 3 181 ? 41.62800  -11.63900 -32.00100 1.000 40.80681 ? 181 LEU L O   1 
ATOM   4818 C CB  . LEU C 3 181 ? 39.65500  -10.02100 -33.97500 1.000 38.12926 ? 181 LEU L CB  1 
ATOM   4819 C CG  . LEU C 3 181 ? 38.38400  -9.32900  -34.46700 1.000 43.62965 ? 181 LEU L CG  1 
ATOM   4820 C CD1 . LEU C 3 181 ? 38.73500  -8.18400  -35.40500 1.000 40.89267 ? 181 LEU L CD1 1 
ATOM   4821 C CD2 . LEU C 3 181 ? 37.45900  -10.32300 -35.15200 1.000 42.91545 ? 181 LEU L CD2 1 
ATOM   4822 N N   . SER C 3 182 ? 41.12900  -12.86300 -33.83000 1.000 45.73819 ? 182 SER L N   1 
ATOM   4823 C CA  . SER C 3 182 ? 42.46700  -13.42400 -33.92800 1.000 52.60350 ? 182 SER L CA  1 
ATOM   4824 C C   . SER C 3 182 ? 43.44800  -12.33900 -34.35500 1.000 45.31083 ? 182 SER L C   1 
ATOM   4825 O O   . SER C 3 182 ? 43.08100  -11.37000 -35.02600 1.000 51.05397 ? 182 SER L O   1 
ATOM   4826 C CB  . SER C 3 182 ? 42.49000  -14.58400 -34.92300 1.000 49.85731 ? 182 SER L CB  1 
ATOM   4827 O OG  . SER C 3 182 ? 42.18800  -14.13600 -36.23300 1.000 50.90750 ? 182 SER L OG  1 
ATOM   4828 N N   . LYS C 3 183 ? 44.71100  -12.50500 -33.95400 1.000 45.41847 ? 183 LYS L N   1 
ATOM   4829 C CA  . LYS C 3 183 ? 45.71800  -11.49900 -34.27700 1.000 51.38955 ? 183 LYS L CA  1 
ATOM   4830 C C   . LYS C 3 183 ? 45.88900  -11.33800 -35.78100 1.000 53.76213 ? 183 LYS L C   1 
ATOM   4831 O O   . LYS C 3 183 ? 46.26900  -10.25900 -36.25100 1.000 58.28286 ? 183 LYS L O   1 
ATOM   4832 C CB  . LYS C 3 183 ? 47.05500  -11.85600 -33.62700 1.000 61.61643 ? 183 LYS L CB  1 
ATOM   4833 C CG  . LYS C 3 183 ? 47.97200  -10.65900 -33.41000 1.000 58.15194 ? 183 LYS L CG  1 
ATOM   4834 C CD  . LYS C 3 183 ? 49.42000  -10.99200 -33.73900 1.000 63.52959 ? 183 LYS L CD  1 
ATOM   4835 C CE  . LYS C 3 183 ? 49.82000  -12.34100 -33.16900 1.000 72.34853 ? 183 LYS L CE  1 
ATOM   4836 N NZ  . LYS C 3 183 ? 51.28400  -12.58800 -33.28600 1.000 70.41721 ? 183 LYS L NZ  1 
ATOM   4837 N N   . ALA C 3 184 ? 45.60800  -12.39100 -36.55100 1.000 51.42930 ? 184 ALA L N   1 
ATOM   4838 C CA  . ALA C 3 184 ? 45.67600  -12.28500 -38.00400 1.000 61.52276 ? 184 ALA L CA  1 
ATOM   4839 C C   . ALA C 3 184 ? 44.57900  -11.37200 -38.53900 1.000 63.44980 ? 184 ALA L C   1 
ATOM   4840 O O   . ALA C 3 184 ? 44.85400  -10.42600 -39.28600 1.000 64.63810 ? 184 ALA L O   1 
ATOM   4841 C CB  . ALA C 3 184 ? 45.58100  -13.67400 -38.63600 1.000 47.08660 ? 184 ALA L CB  1 
ATOM   4842 N N   . ASP C 3 185 ? 43.34000  -11.66200 -38.17600 1.000 61.42614 ? 185 ASP L N   1 
ATOM   4843 C CA  . ASP C 3 185 ? 42.21200  -10.84700 -38.60800 1.000 58.72192 ? 185 ASP L CA  1 
ATOM   4844 C C   . ASP C 3 185 ? 42.33400  -9.42000  -38.14700 1.000 50.85646 ? 185 ASP L C   1 
ATOM   4845 O O   . ASP C 3 185 ? 41.89900  -8.50400  -38.82700 1.000 44.00821 ? 185 ASP L O   1 
ATOM   4846 C CB  . ASP C 3 185 ? 40.92400  -11.46200 -38.06900 1.000 52.62091 ? 185 ASP L CB  1 
ATOM   4847 C CG  . ASP C 3 185 ? 40.31900  -12.46200 -39.00700 1.000 68.08120 ? 185 ASP L CG  1 
ATOM   4848 O OD1 . ASP C 3 185 ? 40.89700  -12.69600 -40.08400 1.000 75.26889 ? 185 ASP L OD1 1 
ATOM   4849 O OD2 . ASP C 3 185 ? 39.25100  -13.01000 -38.67100 1.000 72.35944 ? 185 ASP L OD2 1 
ATOM   4850 N N   . TYR C 3 186 ? 42.92700  -9.22700  -36.98100 1.000 56.29539 ? 186 TYR L N   1 
ATOM   4851 C CA  . TYR C 3 186 ? 43.06300  -7.90000  -36.39900 1.000 49.44061 ? 186 TYR L CA  1 
ATOM   4852 C C   . TYR C 3 186 ? 44.03300  -7.05100  -37.15500 1.000 53.10757 ? 186 TYR L C   1 
ATOM   4853 O O   . TYR C 3 186 ? 43.89700  -5.84100  -37.22100 1.000 52.77416 ? 186 TYR L O   1 
ATOM   4854 C CB  . TYR C 3 186 ? 43.52100  -8.03600  -34.95300 1.000 37.88842 ? 186 TYR L CB  1 
ATOM   4855 C CG  . TYR C 3 186 ? 43.84100  -6.74200  -34.25100 1.000 49.53810 ? 186 TYR L CG  1 
ATOM   4856 C CD1 . TYR C 3 186 ? 42.85800  -5.79900  -34.00400 1.000 42.14450 ? 186 TYR L CD1 1 
ATOM   4857 C CD2 . TYR C 3 186 ? 45.12500  -6.47400  -33.80600 1.000 44.73371 ? 186 TYR L CD2 1 
ATOM   4858 C CE1 . TYR C 3 186 ? 43.15000  -4.61800  -33.35100 1.000 40.00456 ? 186 TYR L CE1 1 
ATOM   4859 C CE2 . TYR C 3 186 ? 45.42300  -5.30000  -33.14600 1.000 39.05058 ? 186 TYR L CE2 1 
ATOM   4860 C CZ  . TYR C 3 186 ? 44.43200  -4.37500  -32.92700 1.000 42.35772 ? 186 TYR L CZ  1 
ATOM   4861 O OH  . TYR C 3 186 ? 44.72900  -3.20700  -32.27800 1.000 39.76301 ? 186 TYR L OH  1 
ATOM   4862 N N   . GLU C 3 187 ? 45.04100  -7.68600  -37.70100 1.000 62.74390 ? 187 GLU L N   1 
ATOM   4863 C CA  . GLU C 3 187 ? 46.06400  -6.94900  -38.40900 1.000 60.24875 ? 187 GLU L CA  1 
ATOM   4864 C C   . GLU C 3 187 ? 45.67000  -6.67100  -39.85300 1.000 56.11454 ? 187 GLU L C   1 
ATOM   4865 O O   . GLU C 3 187 ? 46.30600  -5.86900  -40.51400 1.000 64.15103 ? 187 GLU L O   1 
ATOM   4866 C CB  . GLU C 3 187 ? 47.37400  -7.70200  -38.32100 1.000 58.77403 ? 187 GLU L CB  1 
ATOM   4867 C CG  . GLU C 3 187 ? 48.03100  -7.61900  -36.95800 1.000 61.43927 ? 187 GLU L CG  1 
ATOM   4868 C CD  . GLU C 3 187 ? 49.20200  -8.56500  -36.82400 1.000 66.76645 ? 187 GLU L CD  1 
ATOM   4869 O OE1 . GLU C 3 187 ? 49.34900  -9.45000  -37.68800 1.000 70.31627 ? 187 GLU L OE1 1 
ATOM   4870 O OE2 . GLU C 3 187 ? 49.96800  -8.43200  -35.85100 1.000 71.04565 ? 187 GLU L OE2 1 
ATOM   4871 N N   . LYS C 3 188 ? 44.67500  -7.24500  -40.37400 1.000 47.57193 ? 188 LYS L N   1 
ATOM   4872 C CA  . LYS C 3 188 ? 44.21900  -6.92000  -41.71300 1.000 53.49483 ? 188 LYS L CA  1 
ATOM   4873 C C   . LYS C 3 188 ? 43.31700  -5.67100  -41.74000 1.000 56.30819 ? 188 LYS L C   1 
ATOM   4874 O O   . LYS C 3 188 ? 42.79200  -5.30800  -42.78500 1.000 58.89031 ? 188 LYS L O   1 
ATOM   4875 C CB  . LYS C 3 188 ? 43.49300  -8.11400  -42.35800 1.000 53.02005 ? 188 LYS L CB  1 
ATOM   4876 C CG  . LYS C 3 188 ? 42.09300  -8.38500  -41.85000 1.000 61.04495 ? 188 LYS L CG  1 
ATOM   4877 C CD  . LYS C 3 188 ? 41.61800  -9.77100  -42.26000 1.000 60.50398 ? 188 LYS L CD  1 
ATOM   4878 C CE  . LYS C 3 188 ? 40.19000  -10.01500 -41.79300 1.000 66.08781 ? 188 LYS L CE  1 
ATOM   4879 N NZ  . LYS C 3 188 ? 39.70100  -11.39200 -42.07200 1.000 70.41205 ? 188 LYS L NZ  1 
ATOM   4880 N N   . HIS C 3 189 ? 43.12100  -5.01500  -40.60100 1.000 58.58166 ? 189 HIS L N   1 
ATOM   4881 C CA  . HIS C 3 189 ? 42.30600  -3.80200  -40.56600 1.000 40.05573 ? 189 HIS L CA  1 
ATOM   4882 C C   . HIS C 3 189 ? 42.97100  -2.71400  -39.79400 1.000 42.14187 ? 189 HIS L C   1 
ATOM   4883 O O   . HIS C 3 189 ? 43.86000  -2.96900  -39.01200 1.000 46.25818 ? 189 HIS L O   1 
ATOM   4884 C CB  . HIS C 3 189 ? 40.93200  -4.08700  -39.97800 1.000 49.02183 ? 189 HIS L CB  1 
ATOM   4885 C CG  . HIS C 3 189 ? 40.19400  -5.19100  -40.66100 1.000 53.75881 ? 189 HIS L CG  1 
ATOM   4886 N ND1 . HIS C 3 189 ? 39.69100  -5.07100  -41.93600 1.000 52.59883 ? 189 HIS L ND1 1 
ATOM   4887 C CD2 . HIS C 3 189 ? 39.85600  -6.43000  -40.23700 1.000 49.78894 ? 189 HIS L CD2 1 
ATOM   4888 C CE1 . HIS C 3 189 ? 39.08500  -6.19400  -42.27400 1.000 57.99202 ? 189 HIS L CE1 1 
ATOM   4889 N NE2 . HIS C 3 189 ? 39.16800  -7.03300  -41.25900 1.000 59.54115 ? 189 HIS L NE2 1 
ATOM   4890 N N   . LYS C 3 190 ? 42.54100  -1.48300  -40.01600 1.000 42.68629 ? 190 LYS L N   1 
ATOM   4891 C CA  . LYS C 3 190 ? 43.16800  -0.35400  -39.36800 1.000 43.88764 ? 190 LYS L CA  1 
ATOM   4892 C C   . LYS C 3 190 ? 42.30300  0.38200   -38.37900 1.000 47.22826 ? 190 LYS L C   1 
ATOM   4893 O O   . LYS C 3 190 ? 42.73200  0.66500   -37.27800 1.000 52.15008 ? 190 LYS L O   1 
ATOM   4894 C CB  . LYS C 3 190 ? 43.55700  0.66400   -40.42600 1.000 48.92327 ? 190 LYS L CB  1 
ATOM   4895 C CG  . LYS C 3 190 ? 44.11100  1.96200   -39.86500 1.000 52.37713 ? 190 LYS L CG  1 
ATOM   4896 C CD  . LYS C 3 190 ? 44.14800  3.05100   -40.92100 1.000 57.04958 ? 190 LYS L CD  1 
ATOM   4897 C CE  . LYS C 3 190 ? 44.85400  2.57000   -42.17600 1.000 65.15820 ? 190 LYS L CE  1 
ATOM   4898 N NZ  . LYS C 3 190 ? 44.97800  3.63100   -43.21200 1.000 68.95254 ? 190 LYS L NZ  1 
ATOM   4899 N N   . VAL C 3 191 ? 41.09600  0.72400   -38.78400 1.000 48.72648 ? 191 VAL L N   1 
ATOM   4900 C CA  . VAL C 3 191 ? 40.24100  1.54100   -37.92800 1.000 55.94631 ? 191 VAL L CA  1 
ATOM   4901 C C   . VAL C 3 191 ? 39.23600  0.74000   -37.12200 1.000 48.83386 ? 191 VAL L C   1 
ATOM   4902 O O   . VAL C 3 191 ? 38.40700  0.03000   -37.67300 1.000 39.74909 ? 191 VAL L O   1 
ATOM   4903 C CB  . VAL C 3 191 ? 39.51200  2.64500   -38.71900 1.000 55.19206 ? 191 VAL L CB  1 
ATOM   4904 C CG1 . VAL C 3 191 ? 38.59900  3.43600   -37.79800 1.000 51.14146 ? 191 VAL L CG1 1 
ATOM   4905 C CG2 . VAL C 3 191 ? 40.52000  3.55400   -39.39500 1.000 49.05718 ? 191 VAL L CG2 1 
ATOM   4906 N N   . TYR C 3 192 ? 39.33000  0.88400   -35.81500 1.000 42.41419 ? 192 TYR L N   1 
ATOM   4907 C CA  . TYR C 3 192 ? 38.46100  0.15800   -34.89900 1.000 41.01996 ? 192 TYR L CA  1 
ATOM   4908 C C   . TYR C 3 192 ? 37.66800  1.17200   -34.08900 1.000 37.97931 ? 192 TYR L C   1 
ATOM   4909 O O   . TYR C 3 192 ? 38.25200  1.96700   -33.34400 1.000 35.16438 ? 192 TYR L O   1 
ATOM   4910 C CB  . TYR C 3 192 ? 39.27300  -0.76300  -33.98600 1.000 42.52568 ? 192 TYR L CB  1 
ATOM   4911 C CG  . TYR C 3 192 ? 39.81200  -1.97600  -34.70400 1.000 40.91510 ? 192 TYR L CG  1 
ATOM   4912 C CD1 . TYR C 3 192 ? 41.01000  -1.91500  -35.40400 1.000 41.63436 ? 192 TYR L CD1 1 
ATOM   4913 C CD2 . TYR C 3 192 ? 39.11700  -3.17700  -34.69600 1.000 36.29306 ? 192 TYR L CD2 1 
ATOM   4914 C CE1 . TYR C 3 192 ? 41.50300  -3.01900  -36.07000 1.000 38.68017 ? 192 TYR L CE1 1 
ATOM   4915 C CE2 . TYR C 3 192 ? 39.60200  -4.28600  -35.35800 1.000 32.24134 ? 192 TYR L CE2 1 
ATOM   4916 C CZ  . TYR C 3 192 ? 40.79500  -4.20100  -36.04400 1.000 39.38969 ? 192 TYR L CZ  1 
ATOM   4917 O OH  . TYR C 3 192 ? 41.28000  -5.30500  -36.70500 1.000 45.40208 ? 192 TYR L OH  1 
ATOM   4918 N N   . ALA C 3 193 ? 36.34500  1.14500   -34.23500 1.000 32.93219 ? 193 ALA L N   1 
ATOM   4919 C CA  . ALA C 3 193 ? 35.47800  2.16900   -33.67200 1.000 35.90804 ? 193 ALA L CA  1 
ATOM   4920 C C   . ALA C 3 193 ? 34.32500  1.53400   -32.90900 1.000 34.29319 ? 193 ALA L C   1 
ATOM   4921 O O   . ALA C 3 193 ? 33.78000  0.50900   -33.32800 1.000 29.67686 ? 193 ALA L O   1 
ATOM   4922 C CB  . ALA C 3 193 ? 34.92500  3.08600   -34.76900 1.000 30.07730 ? 193 ALA L CB  1 
ATOM   4923 N N   . CYS C 3 194 ? 33.95600  2.15900   -31.79400 1.000 28.84935 ? 194 CYS L N   1 
ATOM   4924 C CA  . CYS C 3 194 ? 32.80600  1.75800   -30.99300 1.000 29.91742 ? 194 CYS L CA  1 
ATOM   4925 C C   . CYS C 3 194 ? 31.79100  2.89100   -31.01300 1.000 24.26930 ? 194 CYS L C   1 
ATOM   4926 O O   . CYS C 3 194 ? 32.08200  3.99600   -30.54300 1.000 26.99909 ? 194 CYS L O   1 
ATOM   4927 C CB  . CYS C 3 194 ? 33.22200  1.42900   -29.55800 1.000 29.00638 ? 194 CYS L CB  1 
ATOM   4928 S SG  . CYS C 3 194 ? 31.83800  1.15600   -28.43000 1.000 47.57848 ? 194 CYS L SG  1 
ATOM   4929 N N   . GLU C 3 195 ? 30.60800  2.62100   -31.55900 1.000 28.13755 ? 195 GLU L N   1 
ATOM   4930 C CA  . GLU C 3 195 ? 29.55200  3.61700   -31.68700 1.000 28.53992 ? 195 GLU L CA  1 
ATOM   4931 C C   . GLU C 3 195 ? 28.46200  3.33800   -30.66200 1.000 28.79667 ? 195 GLU L C   1 
ATOM   4932 O O   . GLU C 3 195 ? 27.91700  2.23100   -30.61400 1.000 28.41527 ? 195 GLU L O   1 
ATOM   4933 C CB  . GLU C 3 195 ? 28.96100  3.61800   -33.09700 1.000 37.10580 ? 195 GLU L CB  1 
ATOM   4934 C CG  . GLU C 3 195 ? 28.16400  4.87200   -33.41700 1.000 39.82659 ? 195 GLU L CG  1 
ATOM   4935 C CD  . GLU C 3 195 ? 27.41400  4.76400   -34.72700 1.000 54.76798 ? 195 GLU L CD  1 
ATOM   4936 O OE1 . GLU C 3 195 ? 26.73400  3.73700   -34.94200 1.000 61.13772 ? 195 GLU L OE1 1 
ATOM   4937 O OE2 . GLU C 3 195 ? 27.50100  5.70700   -35.54200 1.000 67.07306 ? 195 GLU L OE2 1 
ATOM   4938 N N   . VAL C 3 196 ? 28.14000  4.34700   -29.85700 1.000 21.66205 ? 196 VAL L N   1 
ATOM   4939 C CA  . VAL C 3 196 ? 27.23500  4.20000   -28.72500 1.000 19.32940 ? 196 VAL L CA  1 
ATOM   4940 C C   . VAL C 3 196 ? 26.01500  5.08000   -28.95300 1.000 26.03247 ? 196 VAL L C   1 
ATOM   4941 O O   . VAL C 3 196 ? 26.14700  6.29100   -29.17000 1.000 31.62272 ? 196 VAL L O   1 
ATOM   4942 C CB  . VAL C 3 196 ? 27.92800  4.56400   -27.40000 1.000 21.28855 ? 196 VAL L CB  1 
ATOM   4943 C CG1 . VAL C 3 196 ? 26.91200  4.64900   -26.27100 1.000 21.64900 ? 196 VAL L CG1 1 
ATOM   4944 C CG2 . VAL C 3 196 ? 29.01200  3.54900   -27.07900 1.000 21.62907 ? 196 VAL L CG2 1 
ATOM   4945 N N   . THR C 3 197 ? 24.83400  4.47100   -28.89800 1.000 20.42846 ? 197 THR L N   1 
ATOM   4946 C CA  . THR C 3 197 ? 23.56600  5.18300   -28.97300 1.000 27.37007 ? 197 THR L CA  1 
ATOM   4947 C C   . THR C 3 197 ? 22.84100  5.01600   -27.64700 1.000 19.42494 ? 197 THR L C   1 
ATOM   4948 O O   . THR C 3 197 ? 22.72500  3.89600   -27.13700 1.000 25.15572 ? 197 THR L O   1 
ATOM   4949 C CB  . THR C 3 197 ? 22.70200  4.66300   -30.12700 1.000 31.12652 ? 197 THR L CB  1 
ATOM   4950 O OG1 . THR C 3 197 ? 23.43700  4.75200   -31.35400 1.000 32.05595 ? 197 THR L OG1 1 
ATOM   4951 C CG2 . THR C 3 197 ? 21.42400  5.48000   -30.25100 1.000 25.65445 ? 197 THR L CG2 1 
ATOM   4952 N N   . HIS C 3 198 ? 22.36300  6.12400   -27.08800 1.000 23.74292 ? 198 HIS L N   1 
ATOM   4953 C CA  . HIS C 3 198 ? 21.69800  6.09800   -25.79400 1.000 25.01002 ? 198 HIS L CA  1 
ATOM   4954 C C   . HIS C 3 198 ? 20.80300  7.32300   -25.68300 1.000 23.53913 ? 198 HIS L C   1 
ATOM   4955 O O   . HIS C 3 198 ? 21.08500  8.36800   -26.27500 1.000 27.36372 ? 198 HIS L O   1 
ATOM   4956 C CB  . HIS C 3 198 ? 22.71400  6.06000   -24.64300 1.000 19.07456 ? 198 HIS L CB  1 
ATOM   4957 C CG  . HIS C 3 198 ? 22.09600  5.85100   -23.29500 1.000 20.40626 ? 198 HIS L CG  1 
ATOM   4958 N ND1 . HIS C 3 198 ? 21.79600  6.89300   -22.44500 1.000 17.44414 ? 198 HIS L ND1 1 
ATOM   4959 C CD2 . HIS C 3 198 ? 21.72100  4.72100   -22.65000 1.000 19.75076 ? 198 HIS L CD2 1 
ATOM   4960 C CE1 . HIS C 3 198 ? 21.26100  6.41500   -21.33500 1.000 22.48089 ? 198 HIS L CE1 1 
ATOM   4961 N NE2 . HIS C 3 198 ? 21.20500  5.09900   -21.43500 1.000 22.87553 ? 198 HIS L NE2 1 
ATOM   4962 N N   . GLN C 3 199 ? 19.71900  7.17600   -24.91600 1.000 20.42371 ? 199 GLN L N   1 
ATOM   4963 C CA  . GLN C 3 199 ? 18.76200  8.26700   -24.75300 1.000 22.35249 ? 199 GLN L CA  1 
ATOM   4964 C C   . GLN C 3 199 ? 19.42400  9.52400   -24.19900 1.000 25.57205 ? 199 GLN L C   1 
ATOM   4965 O O   . GLN C 3 199 ? 19.01400  10.64100  -24.53500 1.000 33.27277 ? 199 GLN L O   1 
ATOM   4966 C CB  . GLN C 3 199 ? 17.61600  7.81400   -23.84500 1.000 24.85152 ? 199 GLN L CB  1 
ATOM   4967 C CG  . GLN C 3 199 ? 16.61500  8.90100   -23.49000 1.000 35.86418 ? 199 GLN L CG  1 
ATOM   4968 C CD  . GLN C 3 199 ? 15.48400  8.38700   -22.62000 1.000 37.51039 ? 199 GLN L CD  1 
ATOM   4969 O OE1 . GLN C 3 199 ? 15.47600  7.22500   -22.21300 1.000 37.09851 ? 199 GLN L OE1 1 
ATOM   4970 N NE2 . GLN C 3 199 ? 14.52200  9.25500   -22.32500 1.000 43.75010 ? 199 GLN L NE2 1 
ATOM   4971 N N   . GLY C 3 200 ? 20.45500  9.36700   -23.36900 1.000 24.74462 ? 200 GLY L N   1 
ATOM   4972 C CA  . GLY C 3 200 ? 21.15000  10.50400  -22.79600 1.000 19.52067 ? 200 GLY L CA  1 
ATOM   4973 C C   . GLY C 3 200 ? 22.07700  11.24100  -23.73700 1.000 20.51738 ? 200 GLY L C   1 
ATOM   4974 O O   . GLY C 3 200 ? 22.56900  12.31500  -23.38000 1.000 30.00416 ? 200 GLY L O   1 
ATOM   4975 N N   . LEU C 3 201 ? 22.32900  10.69600  -24.92300 1.000 22.85193 ? 201 LEU L N   1 
ATOM   4976 C CA  . LEU C 3 201 ? 23.18300  11.32700  -25.92100 1.000 29.75670 ? 201 LEU L CA  1 
ATOM   4977 C C   . LEU C 3 201 ? 22.31500  11.88800  -27.03900 1.000 30.50377 ? 201 LEU L C   1 
ATOM   4978 O O   . LEU C 3 201 ? 21.44700  11.18500  -27.56700 1.000 32.14639 ? 201 LEU L O   1 
ATOM   4979 C CB  . LEU C 3 201 ? 24.19700  10.32900  -26.48500 1.000 31.89858 ? 201 LEU L CB  1 
ATOM   4980 C CG  . LEU C 3 201 ? 25.14200  9.67200   -25.47600 1.000 24.35469 ? 201 LEU L CG  1 
ATOM   4981 C CD1 . LEU C 3 201 ? 25.87800  8.50500   -26.11400 1.000 24.64574 ? 201 LEU L CD1 1 
ATOM   4982 C CD2 . LEU C 3 201 ? 26.12400  10.69100  -24.91800 1.000 25.46096 ? 201 LEU L CD2 1 
ATOM   4983 N N   . SER C 3 202 ? 22.54900  13.15400  -27.39200 1.000 31.35105 ? 202 SER L N   1 
ATOM   4984 C CA  . SER C 3 202 ? 21.76600  13.78000  -28.45400 1.000 31.18635 ? 202 SER L CA  1 
ATOM   4985 C C   . SER C 3 202 ? 22.06600  13.14700  -29.80700 1.000 39.42979 ? 202 SER L C   1 
ATOM   4986 O O   . SER C 3 202 ? 21.17000  13.00700  -30.64700 1.000 39.19706 ? 202 SER L O   1 
ATOM   4987 C CB  . SER C 3 202 ? 22.03700  15.28400  -28.49100 1.000 33.63587 ? 202 SER L CB  1 
ATOM   4988 O OG  . SER C 3 202 ? 23.37100  15.55100  -28.88500 1.000 46.85178 ? 202 SER L OG  1 
ATOM   4989 N N   . SER C 3 203 ? 23.31400  12.76300  -30.03400 1.000 36.16720 ? 203 SER L N   1 
ATOM   4990 C CA  . SER C 3 203 ? 23.74000  12.07700  -31.24200 1.000 35.73692 ? 203 SER L CA  1 
ATOM   4991 C C   . SER C 3 203 ? 24.66600  10.94100  -30.84200 1.000 44.56953 ? 203 SER L C   1 
ATOM   4992 O O   . SER C 3 203 ? 25.26700  10.97500  -29.76100 1.000 39.37641 ? 203 SER L O   1 
ATOM   4993 C CB  . SER C 3 203 ? 24.45000  13.03000  -32.21400 1.000 44.41784 ? 203 SER L CB  1 
ATOM   4994 O OG  . SER C 3 203 ? 25.63500  13.55600  -31.64300 1.000 54.53047 ? 203 SER L OG  1 
ATOM   4995 N N   . PRO C 3 204 ? 24.78200  9.90500   -31.67500 1.000 40.91919 ? 204 PRO L N   1 
ATOM   4996 C CA  . PRO C 3 204 ? 25.67400  8.78800   -31.34100 1.000 33.26301 ? 204 PRO L CA  1 
ATOM   4997 C C   . PRO C 3 204 ? 27.10000  9.25900   -31.09300 1.000 34.19995 ? 204 PRO L C   1 
ATOM   4998 O O   . PRO C 3 204 ? 27.62700  10.11400  -31.80700 1.000 38.16870 ? 204 PRO L O   1 
ATOM   4999 C CB  . PRO C 3 204 ? 25.59500  7.87400   -32.57200 1.000 38.22718 ? 204 PRO L CB  1 
ATOM   5000 C CG  . PRO C 3 204 ? 24.58900  8.48000   -33.50100 1.000 41.36511 ? 204 PRO L CG  1 
ATOM   5001 C CD  . PRO C 3 204 ? 23.89400  9.60000   -32.80900 1.000 45.76679 ? 204 PRO L CD  1 
ATOM   5002 N N   . VAL C 3 205 ? 27.71900  8.69200   -30.06100 1.000 30.23586 ? 205 VAL L N   1 
ATOM   5003 C CA  . VAL C 3 205 ? 29.09400  9.00400   -29.69000 1.000 32.78993 ? 205 VAL L CA  1 
ATOM   5004 C C   . VAL C 3 205 ? 29.98300  7.85700   -30.14500 1.000 30.39088 ? 205 VAL L C   1 
ATOM   5005 O O   . VAL C 3 205 ? 29.68100  6.68600   -29.88400 1.000 38.11741 ? 205 VAL L O   1 
ATOM   5006 C CB  . VAL C 3 205 ? 29.22100  9.23700   -28.17400 1.000 27.41622 ? 205 VAL L CB  1 
ATOM   5007 C CG1 . VAL C 3 205 ? 30.67200  9.11200   -27.73200 1.000 31.71674 ? 205 VAL L CG1 1 
ATOM   5008 C CG2 . VAL C 3 205 ? 28.65800  10.59900  -27.79900 1.000 34.82662 ? 205 VAL L CG2 1 
ATOM   5009 N N   . THR C 3 206 ? 31.07400  8.18700   -30.83000 1.000 36.77577 ? 206 THR L N   1 
ATOM   5010 C CA  . THR C 3 206 ? 31.99700  7.19300   -31.35700 1.000 39.31414 ? 206 THR L CA  1 
ATOM   5011 C C   . THR C 3 206 ? 33.37100  7.38800   -30.73600 1.000 34.87054 ? 206 THR L C   1 
ATOM   5012 O O   . THR C 3 206 ? 33.91700  8.49600   -30.75700 1.000 33.20989 ? 206 THR L O   1 
ATOM   5013 C CB  . THR C 3 206 ? 32.10000  7.27800   -32.88200 1.000 30.48382 ? 206 THR L CB  1 
ATOM   5014 O OG1 . THR C 3 206 ? 30.82200  6.99600   -33.46600 1.000 38.43336 ? 206 THR L OG1 1 
ATOM   5015 C CG2 . THR C 3 206 ? 33.12000  6.27700   -33.40300 1.000 36.79363 ? 206 THR L CG2 1 
ATOM   5016 N N   . LYS C 3 207 ? 33.91800  6.31300   -30.17700 1.000 36.24336 ? 207 LYS L N   1 
ATOM   5017 C CA  . LYS C 3 207 ? 35.30100  6.27100   -29.72600 1.000 30.15576 ? 207 LYS L CA  1 
ATOM   5018 C C   . LYS C 3 207 ? 36.05600  5.28500   -30.60400 1.000 35.27584 ? 207 LYS L C   1 
ATOM   5019 O O   . LYS C 3 207 ? 35.64500  4.12700   -30.74100 1.000 34.96485 ? 207 LYS L O   1 
ATOM   5020 C CB  . LYS C 3 207 ? 35.39800  5.86400   -28.25400 1.000 36.70444 ? 207 LYS L CB  1 
ATOM   5021 C CG  . LYS C 3 207 ? 34.62400  6.76900   -27.31100 1.000 31.00265 ? 207 LYS L CG  1 
ATOM   5022 C CD  . LYS C 3 207 ? 35.05900  8.21600   -27.45000 1.000 41.38581 ? 207 LYS L CD  1 
ATOM   5023 C CE  . LYS C 3 207 ? 34.46900  9.08700   -26.35400 1.000 43.91842 ? 207 LYS L CE  1 
ATOM   5024 N NZ  . LYS C 3 207 ? 35.42900  10.13500  -25.92000 1.000 47.14641 ? 207 LYS L NZ  1 
ATOM   5025 N N   . SER C 3 208 ? 37.16900  5.72800   -31.15800 1.000 40.56335 ? 208 SER L N   1 
ATOM   5026 C CA  . SER C 3 208 ? 37.91500  4.91700   -32.08800 1.000 35.80792 ? 208 SER L CA  1 
ATOM   5027 C C   . SER C 3 208 ? 39.39500  5.04200   -31.95900 1.000 41.21809 ? 208 SER L C   1 
ATOM   5028 O O   . SER C 3 208 ? 39.88900  5.99700   -31.39900 1.000 49.59497 ? 208 SER L O   1 
ATOM   5029 C CB  . SER C 3 208 ? 37.55500  5.35700   -33.50200 1.000 41.65127 ? 208 SER L CB  1 
ATOM   5030 O OG  . SER C 3 208 ? 37.80700  6.73100   -33.68900 1.000 43.69045 ? 208 SER L OG  1 
ATOM   5031 N N   . PHE C 3 209 ? 40.11400  4.07900   -32.49100 1.000 41.55190 ? 209 PHE L N   1 
ATOM   5032 C CA  . PHE C 3 209 ? 41.55400  4.16000   -32.51100 1.000 39.92108 ? 209 PHE L CA  1 
ATOM   5033 C C   . PHE C 3 209 ? 42.08500  3.57500   -33.80100 1.000 43.64959 ? 209 PHE L C   1 
ATOM   5034 O O   . PHE C 3 209 ? 41.37700  2.87400   -34.50700 1.000 41.85079 ? 209 PHE L O   1 
ATOM   5035 C CB  . PHE C 3 209 ? 42.19600  3.46600   -31.31200 1.000 39.68857 ? 209 PHE L CB  1 
ATOM   5036 C CG  . PHE C 3 209 ? 42.12300  1.96800   -31.35700 1.000 41.68215 ? 209 PHE L CG  1 
ATOM   5037 C CD1 . PHE C 3 209 ? 43.08700  1.23600   -32.01600 1.000 35.98338 ? 209 PHE L CD1 1 
ATOM   5038 C CD2 . PHE C 3 209 ? 41.09700  1.29600   -30.72400 1.000 37.89280 ? 209 PHE L CD2 1 
ATOM   5039 C CE1 . PHE C 3 209 ? 43.02400  -0.13700  -32.05600 1.000 39.05792 ? 209 PHE L CE1 1 
ATOM   5040 C CE2 . PHE C 3 209 ? 41.02800  -0.07600  -30.75600 1.000 33.07391 ? 209 PHE L CE2 1 
ATOM   5041 C CZ  . PHE C 3 209 ? 41.99400  -0.79500  -31.42400 1.000 42.36252 ? 209 PHE L CZ  1 
ATOM   5042 N N   . ASN C 3 210 ? 43.33700  3.86700   -34.09900 1.000 47.04623 ? 210 ASN L N   1 
ATOM   5043 C CA  . ASN C 3 210 ? 43.96600  3.34300   -35.29400 1.000 59.35665 ? 210 ASN L CA  1 
ATOM   5044 C C   . ASN C 3 210 ? 45.03200  2.37000   -34.86800 1.000 51.09911 ? 210 ASN L C   1 
ATOM   5045 O O   . ASN C 3 210 ? 45.89300  2.70100   -34.06600 1.000 51.59984 ? 210 ASN L O   1 
ATOM   5046 C CB  . ASN C 3 210 ? 44.55100  4.48200   -36.13700 1.000 64.61775 ? 210 ASN L CB  1 
ATOM   5047 C CG  . ASN C 3 210 ? 43.54200  5.08700   -37.08100 1.000 58.98208 ? 210 ASN L CG  1 
ATOM   5048 O OD1 . ASN C 3 210 ? 43.26300  4.54200   -38.14100 1.000 59.09559 ? 210 ASN L OD1 1 
ATOM   5049 N ND2 . ASN C 3 210 ? 42.99500  6.22800   -36.70200 1.000 64.71340 ? 210 ASN L ND2 1 
ATOM   5050 N N   . ARG C 3 211 ? 44.96700  1.16300   -35.37700 1.000 42.58761 ? 211 ARG L N   1 
ATOM   5051 C CA  . ARG C 3 211 ? 45.90100  0.16300   -34.90900 1.000 49.78743 ? 211 ARG L CA  1 
ATOM   5052 C C   . ARG C 3 211 ? 47.34400  0.58700   -35.06600 1.000 60.71994 ? 211 ARG L C   1 
ATOM   5053 O O   . ARG C 3 211 ? 47.76000  0.98600   -36.14300 1.000 68.52239 ? 211 ARG L O   1 
ATOM   5054 C CB  . ARG C 3 211 ? 45.66200  -1.17600  -35.59100 1.000 49.09157 ? 211 ARG L CB  1 
ATOM   5055 C CG  . ARG C 3 211 ? 46.63400  -2.25500  -35.15600 1.000 52.65302 ? 211 ARG L CG  1 
ATOM   5056 C CD  . ARG C 3 211 ? 46.36500  -3.58100  -35.84600 1.000 51.78430 ? 211 ARG L CD  1 
ATOM   5057 N NE  . ARG C 3 211 ? 46.00600  -3.42800  -37.24700 1.000 53.80161 ? 211 ARG L NE  1 
ATOM   5058 C CZ  . ARG C 3 211 ? 46.85500  -3.58900  -38.25300 1.000 59.79862 ? 211 ARG L CZ  1 
ATOM   5059 N NH1 . ARG C 3 211 ? 48.11900  -3.89500  -38.01300 1.000 55.61887 ? 211 ARG L NH1 1 
ATOM   5060 N NH2 . ARG C 3 211 ? 46.44200  -3.43600  -39.49800 1.000 60.44858 ? 211 ARG L NH2 1 
ATOM   5061 N N   . GLY C 3 212 ? 48.09800  0.52100   -33.98400 1.000 65.43756 ? 212 GLY L N   1 
ATOM   5062 C CA  . GLY C 3 212 ? 49.50800  0.85800   -34.03000 1.000 68.36158 ? 212 GLY L CA  1 
ATOM   5063 C C   . GLY C 3 212 ? 49.85100  2.28600   -33.74800 1.000 73.10618 ? 212 GLY L C   1 
ATOM   5064 O O   . GLY C 3 212 ? 50.83600  2.79200   -34.25800 1.000 80.63526 ? 212 GLY L O   1 
ATOM   5065 N N   . GLU C 3 213 ? 49.07000  2.95000   -32.92200 1.000 71.06233 ? 213 GLU L N   1 
ATOM   5066 C CA  . GLU C 3 213 ? 49.29500  4.35700   -32.71900 1.000 67.86084 ? 213 GLU L CA  1 
ATOM   5067 C C   . GLU C 3 213 ? 49.09700  4.72600   -31.27700 1.000 69.78554 ? 213 GLU L C   1 
ATOM   5068 O O   . GLU C 3 213 ? 49.45600  5.82200   -30.86900 1.000 74.53511 ? 213 GLU L O   1 
ATOM   5069 C CB  . GLU C 3 213 ? 48.33500  5.16900   -33.59100 1.000 69.50145 ? 213 GLU L CB  1 
ATOM   5070 C CG  . GLU C 3 213 ? 48.28100  4.73700   -35.04800 1.000 73.99822 ? 213 GLU L CG  1 
ATOM   5071 C CD  . GLU C 3 213 ? 48.00300  5.88200   -36.00600 1.000 81.69775 ? 213 GLU L CD  1 
ATOM   5072 O OE1 . GLU C 3 213 ? 47.77700  7.01900   -35.54500 1.000 76.73224 ? 213 GLU L OE1 1 
ATOM   5073 O OE2 . GLU C 3 213 ? 48.00800  5.64000   -37.23000 1.000 81.71207 ? 213 GLU L OE2 1 
HETATM 5074 C C1  . NAG D 4 .   ? -2.44800  -4.33200  22.18000  1.000 32.30532 ? 1   NAG A C1  1 
HETATM 5075 C C2  . NAG D 4 .   ? -0.98700  -3.94100  22.34600  1.000 38.38385 ? 1   NAG A C2  1 
HETATM 5076 C C3  . NAG D 4 .   ? -0.78000  -2.51800  21.86600  1.000 49.02405 ? 1   NAG A C3  1 
HETATM 5077 C C4  . NAG D 4 .   ? -1.27700  -2.37400  20.44000  1.000 53.55665 ? 1   NAG A C4  1 
HETATM 5078 C C5  . NAG D 4 .   ? -2.72200  -2.82500  20.34500  1.000 49.74722 ? 1   NAG A C5  1 
HETATM 5079 C C6  . NAG D 4 .   ? -3.17300  -2.79200  18.89200  1.000 49.49171 ? 1   NAG A C6  1 
HETATM 5080 C C7  . NAG D 4 .   ? -0.16000  -5.19500  24.26300  1.000 26.33005 ? 1   NAG A C7  1 
HETATM 5081 C C8  . NAG D 4 .   ? 0.47400   -5.06800  25.61000  1.000 27.96384 ? 1   NAG A C8  1 
HETATM 5082 N N2  . NAG D 4 .   ? -0.56800  -4.05800  23.72600  1.000 29.99536 ? 1   NAG A N2  1 
HETATM 5083 O O3  . NAG D 4 .   ? 0.61200   -2.23100  21.92700  1.000 59.89206 ? 1   NAG A O3  1 
HETATM 5084 O O4  . NAG D 4 .   ? -1.20500  -1.00800  20.03400  1.000 60.08080 ? 1   NAG A O4  1 
HETATM 5085 O O5  . NAG D 4 .   ? -2.86700  -4.15100  20.83300  1.000 40.49590 ? 1   NAG A O5  1 
HETATM 5086 O O6  . NAG D 4 .   ? -4.59500  -2.89800  18.83000  1.000 53.32866 ? 1   NAG A O6  1 
HETATM 5087 O O7  . NAG D 4 .   ? -0.28800  -6.26600  23.71000  1.000 26.44587 ? 1   NAG A O7  1 
HETATM 5088 C C1  . NAG D 4 .   ? -0.17200  -0.87300  19.05000  1.000 62.46107 ? 2   NAG A C1  1 
HETATM 5089 C C2  . NAG D 4 .   ? -0.25000  0.48300   18.36100  1.000 69.82241 ? 2   NAG A C2  1 
HETATM 5090 C C3  . NAG D 4 .   ? 0.84700   0.56000   17.31300  1.000 72.43483 ? 2   NAG A C3  1 
HETATM 5091 C C4  . NAG D 4 .   ? 2.18300   0.36600   18.00400  1.000 80.02106 ? 2   NAG A C4  1 
HETATM 5092 C C5  . NAG D 4 .   ? 2.17600   -0.98000  18.70200  1.000 78.50236 ? 2   NAG A C5  1 
HETATM 5093 C C6  . NAG D 4 .   ? 3.48200   -1.21100  19.43900  1.000 66.45639 ? 2   NAG A C6  1 
HETATM 5094 C C7  . NAG D 4 .   ? -2.51200  1.30600   18.41800  1.000 66.58177 ? 2   NAG A C7  1 
HETATM 5095 C C8  . NAG D 4 .   ? -3.80800  1.49200   17.69300  1.000 61.43611 ? 2   NAG A C8  1 
HETATM 5096 N N2  . NAG D 4 .   ? -1.54000  0.70600   17.74500  1.000 65.08737 ? 2   NAG A N2  1 
HETATM 5097 O O3  . NAG D 4 .   ? 0.82600   1.82700   16.66600  1.000 79.41996 ? 2   NAG A O3  1 
HETATM 5098 O O4  . NAG D 4 .   ? 3.24800   0.41400   17.05200  1.000 86.68619 ? 2   NAG A O4  1 
HETATM 5099 O O5  . NAG D 4 .   ? 1.11200   -1.00900  19.64300  1.000 77.82436 ? 2   NAG A O5  1 
HETATM 5100 O O6  . NAG D 4 .   ? 3.50500   -0.34000  20.56900  1.000 72.42626 ? 2   NAG A O6  1 
HETATM 5101 O O7  . NAG D 4 .   ? -2.36000  1.68500   19.56000  1.000 70.00327 ? 2   NAG A O7  1 
HETATM 5102 C C1  . NAG E 5 .   ? -10.84600 -3.47300  20.08600  1.000 62.87721 ? 301 NAG B C1  1 
HETATM 5103 C C2  . NAG E 5 .   ? -11.82700 -2.84100  21.06300  1.000 67.23272 ? 301 NAG B C2  1 
HETATM 5104 C C3  . NAG E 5 .   ? -12.66300 -1.78600  20.37300  1.000 76.53905 ? 301 NAG B C3  1 
HETATM 5105 C C4  . NAG E 5 .   ? -11.77500 -0.76600  19.69700  1.000 76.32215 ? 301 NAG B C4  1 
HETATM 5106 C C5  . NAG E 5 .   ? -10.80000 -1.46400  18.76300  1.000 73.05495 ? 301 NAG B C5  1 
HETATM 5107 C C6  . NAG E 5 .   ? -9.83700  -0.45900  18.15200  1.000 60.07560 ? 301 NAG B C6  1 
HETATM 5108 C C7  . NAG E 5 .   ? -12.81400 -4.11400  22.87000  1.000 60.75622 ? 301 NAG B C7  1 
HETATM 5109 C C8  . NAG E 5 .   ? -13.73800 -5.23000  23.24200  1.000 51.13214 ? 301 NAG B C8  1 
HETATM 5110 N N2  . NAG E 5 .   ? -12.74900 -3.82700  21.58100  1.000 65.28128 ? 301 NAG B N2  1 
HETATM 5111 O O3  . NAG E 5 .   ? -13.48100 -1.13600  21.34800  1.000 81.82987 ? 301 NAG B O3  1 
HETATM 5112 O O4  . NAG E 5 .   ? -12.59700 0.13200   18.95100  1.000 88.86690 ? 301 NAG B O4  1 
HETATM 5113 O O5  . NAG E 5 .   ? -10.05500 -2.46600  19.45500  1.000 60.97015 ? 301 NAG B O5  1 
HETATM 5114 O O6  . NAG E 5 .   ? -9.23900  -1.06800  17.00600  1.000 77.54753 ? 301 NAG B O6  1 
HETATM 5115 O O7  . NAG E 5 .   ? -12.16400 -3.50200  23.69300  1.000 72.90949 ? 301 NAG B O7  1 
HETATM 5116 C C1  . EDO F 6 .   ? 35.556    -9.352    -21.507   1     26.44502 ? 301 EDO H C1  1 
HETATM 5117 O O1  . EDO F 6 .   ? 35.188    -8.037    -21.115   1     27.04831 ? 301 EDO H O1  1 
HETATM 5118 C C2  . EDO F 6 .   ? 34.398    -10.31    -21.28    1     35.50809 ? 301 EDO H C2  1 
HETATM 5119 C C1  . EDO G 6 .   ? 10.72800  -20.19100 -5.37700  1.000 36.13977 ? 301 EDO L C1  1 
HETATM 5120 O O1  . EDO G 6 .   ? 10.94400  -20.08100 -6.78400  1.000 37.79300 ? 301 EDO L O1  1 
HETATM 5121 C C2  . EDO G 6 .   ? 12.05300  -20.15000 -4.62800  1.000 31.36186 ? 301 EDO L C2  1 
HETATM 5122 O O2  . EDO G 6 .   ? 12.63400  -18.84700 -4.70900  1.000 27.52851 ? 301 EDO L O2  1 
HETATM 5123 C C1  . EDO H 6 .   ? 32.50300  11.37200  -33.51500 1.000 51.86618 ? 302 EDO L C1  1 
HETATM 5124 O O1  . EDO H 6 .   ? 31.54900  10.57200  -34.22000 1.000 53.41124 ? 302 EDO L O1  1 
HETATM 5125 C C2  . EDO H 6 .   ? 32.54800  10.99500  -32.03700 1.000 49.55265 ? 302 EDO L C2  1 
HETATM 5126 O O2  . EDO H 6 .   ? 31.28800  11.23500  -31.40600 1.000 43.22772 ? 302 EDO L O2  1 
HETATM 5127 C C1  . EDO I 6 .   ? 18.38500  -2.51900  4.16600   1.000 30.99999 ? 303 EDO L C1  1 
HETATM 5128 O O1  . EDO I 6 .   ? 19.52500  -3.36800  4.26700   1.000 23.73704 ? 303 EDO L O1  1 
HETATM 5129 C C2  . EDO I 6 .   ? 18.69800  -1.31700  3.27700   1.000 26.79411 ? 303 EDO L C2  1 
HETATM 5130 O O2  . EDO I 6 .   ? 18.44500  -1.63200  1.91200   1.000 16.60881 ? 303 EDO L O2  1 
HETATM 5131 C C1  . EDO J 6 .   ? 22.40500  6.54800   -1.39300  1.000 28.48664 ? 304 EDO L C1  1 
HETATM 5132 O O1  . EDO J 6 .   ? 21.33600  6.62700   -0.46000  1.000 27.92965 ? 304 EDO L O1  1 
HETATM 5133 C C2  . EDO J 6 .   ? 22.26700  7.70000   -2.37700  1.000 24.51498 ? 304 EDO L C2  1 
HETATM 5134 O O2  . EDO J 6 .   ? 23.41700  7.74400   -3.19400  1.000 26.16380 ? 304 EDO L O2  1 
HETATM 5135 C C1  . EDO K 6 .   ? 23.47400  -3.68700  -28.61800 1.000 44.14015 ? 305 EDO L C1  1 
HETATM 5136 O O1  . EDO K 6 .   ? 24.31700  -2.85700  -27.82300 1.000 36.53952 ? 305 EDO L O1  1 
HETATM 5137 C C2  . EDO K 6 .   ? 24.30600  -4.37800  -29.68700 1.000 41.56497 ? 305 EDO L C2  1 
HETATM 5138 O O2  . EDO K 6 .   ? 24.17900  -3.67600  -30.92200 1.000 43.67765 ? 305 EDO L O2  1 
HETATM 5139 O O   . HOH L 7 .   ? 11.24400  -19.80400 48.51600  1.000 49.27632 ? 401 HOH B O   1 
HETATM 5140 O O   . HOH L 7 .   ? 0.64200   -30.80700 33.63400  1.000 48.14596 ? 402 HOH B O   1 
HETATM 5141 O O   . HOH L 7 .   ? 9.38200   -8.44700  46.49900  1.000 44.98654 ? 403 HOH B O   1 
HETATM 5142 O O   . HOH L 7 .   ? 0.10400   -1.66800  25.07000  1.000 31.22430 ? 404 HOH B O   1 
HETATM 5143 O O   . HOH L 7 .   ? 15.38300  -10.46200 27.75400  1.000 20.70777 ? 405 HOH B O   1 
HETATM 5144 O O   . HOH L 7 .   ? 24.79400  -16.96800 24.67600  1.000 35.04581 ? 406 HOH B O   1 
HETATM 5145 O O   . HOH L 7 .   ? -5.09400  -18.06900 20.28300  1.000 33.65774 ? 407 HOH B O   1 
HETATM 5146 O O   . HOH L 7 .   ? -22.03200 -20.93800 24.94500  1.000 41.43622 ? 408 HOH B O   1 
HETATM 5147 O O   . HOH L 7 .   ? 0.52100   2.09100   26.51400  1.000 50.01837 ? 409 HOH B O   1 
HETATM 5148 O O   . HOH L 7 .   ? 23.96100  -8.14300  39.15500  1.000 44.82811 ? 410 HOH B O   1 
HETATM 5149 O O   . HOH L 7 .   ? 14.77000  -5.42300  27.21400  1.000 41.60842 ? 411 HOH B O   1 
HETATM 5150 O O   . HOH L 7 .   ? 7.93300   -6.65600  36.00100  1.000 27.50865 ? 412 HOH B O   1 
HETATM 5151 O O   . HOH L 7 .   ? 21.09500  -22.87800 47.64300  1.000 45.60866 ? 413 HOH B O   1 
HETATM 5152 O O   . HOH L 7 .   ? 18.36700  -10.70500 16.53500  1.000 36.50211 ? 414 HOH B O   1 
HETATM 5153 O O   . HOH L 7 .   ? -2.38300  -32.60800 40.39200  1.000 44.35947 ? 415 HOH B O   1 
HETATM 5154 O O   . HOH L 7 .   ? 5.05700   -28.31500 30.74000  1.000 39.21611 ? 416 HOH B O   1 
HETATM 5155 O O   . HOH L 7 .   ? -9.74000  -11.66200 20.21800  1.000 27.51777 ? 417 HOH B O   1 
HETATM 5156 O O   . HOH L 7 .   ? 21.22600  -19.49800 33.51000  1.000 35.50771 ? 418 HOH B O   1 
HETATM 5157 O O   . HOH L 7 .   ? 13.14400  -14.65900 38.52500  1.000 27.40987 ? 419 HOH B O   1 
HETATM 5158 O O   . HOH L 7 .   ? 19.30200  -7.97500  22.76100  1.000 36.28449 ? 420 HOH B O   1 
HETATM 5159 O O   . HOH L 7 .   ? -6.18500  -21.27500 48.01900  1.000 52.99869 ? 421 HOH B O   1 
HETATM 5160 O O   . HOH L 7 .   ? 21.28300  -7.18600  18.72100  1.000 32.74565 ? 422 HOH B O   1 
HETATM 5161 O O   . HOH L 7 .   ? 27.32000  -10.70600 47.18100  1.000 37.01584 ? 423 HOH B O   1 
HETATM 5162 O O   . HOH L 7 .   ? 10.46600  -27.86100 42.24400  1.000 40.71710 ? 424 HOH B O   1 
HETATM 5163 O O   . HOH L 7 .   ? 21.76300  -21.32800 31.55900  1.000 37.88647 ? 425 HOH B O   1 
HETATM 5164 O O   . HOH L 7 .   ? 3.45800   -13.98800 43.03600  1.000 36.65195 ? 426 HOH B O   1 
HETATM 5165 O O   . HOH L 7 .   ? -0.59300  -19.04700 37.81500  1.000 27.89299 ? 427 HOH B O   1 
HETATM 5166 O O   . HOH L 7 .   ? -14.55700 -21.27100 16.29100  1.000 39.61446 ? 428 HOH B O   1 
HETATM 5167 O O   . HOH L 7 .   ? 14.74400  -9.27100  25.12900  1.000 22.66250 ? 429 HOH B O   1 
HETATM 5168 O O   . HOH L 7 .   ? -6.59500  -13.87100 33.69600  1.000 41.30111 ? 430 HOH B O   1 
HETATM 5169 O O   . HOH L 7 .   ? -18.15900 -12.61100 28.15800  1.000 26.21751 ? 431 HOH B O   1 
HETATM 5170 O O   . HOH L 7 .   ? 20.15700  -14.33000 16.21100  1.000 24.53567 ? 432 HOH B O   1 
HETATM 5171 O O   . HOH L 7 .   ? 22.71500  -15.15500 43.34600  1.000 35.25629 ? 433 HOH B O   1 
HETATM 5172 O O   . HOH L 7 .   ? -12.20500 -4.60100  16.64600  1.000 53.47833 ? 434 HOH B O   1 
HETATM 5173 O O   . HOH L 7 .   ? 7.01200   -22.95200 26.90600  1.000 22.15755 ? 435 HOH B O   1 
HETATM 5174 O O   . HOH L 7 .   ? 2.08600   -24.62900 21.94200  1.000 29.18250 ? 436 HOH B O   1 
HETATM 5175 O O   . HOH L 7 .   ? 11.76900  -14.25600 48.57600  1.000 39.13218 ? 437 HOH B O   1 
HETATM 5176 O O   . HOH L 7 .   ? 22.83000  -20.44300 27.67500  1.000 33.80221 ? 438 HOH B O   1 
HETATM 5177 O O   . HOH L 7 .   ? -16.93600 -26.60000 41.50800  1.000 48.58575 ? 439 HOH B O   1 
HETATM 5178 O O   . HOH L 7 .   ? 14.03000  -17.29200 49.07500  1.000 39.95195 ? 440 HOH B O   1 
HETATM 5179 O O   . HOH L 7 .   ? 13.56600  -7.81600  29.11600  1.000 32.54394 ? 441 HOH B O   1 
HETATM 5180 O O   . HOH L 7 .   ? -15.91600 -7.34600  35.45900  1.000 60.77294 ? 442 HOH B O   1 
HETATM 5181 O O   . HOH L 7 .   ? 27.43000  -11.73900 38.44200  1.000 35.24090 ? 443 HOH B O   1 
HETATM 5182 O O   . HOH L 7 .   ? 11.01700  -19.80500 22.76600  1.000 21.48286 ? 444 HOH B O   1 
HETATM 5183 O O   . HOH L 7 .   ? -21.66300 -13.88700 25.43000  1.000 25.21603 ? 445 HOH B O   1 
HETATM 5184 O O   . HOH L 7 .   ? -13.58600 -27.84900 29.08200  1.000 45.37859 ? 446 HOH B O   1 
HETATM 5185 O O   . HOH L 7 .   ? 14.22700  -3.19400  15.16300  1.000 32.75262 ? 447 HOH B O   1 
HETATM 5186 O O   . HOH L 7 .   ? 24.12100  -13.93300 23.03700  1.000 27.48187 ? 448 HOH B O   1 
HETATM 5187 O O   . HOH L 7 .   ? 4.10500   -32.36500 45.82000  1.000 42.66875 ? 449 HOH B O   1 
HETATM 5188 O O   . HOH L 7 .   ? -0.13400  -30.97800 38.30800  1.000 41.33228 ? 450 HOH B O   1 
HETATM 5189 O O   . HOH L 7 .   ? 16.71600  -7.28600  26.27600  1.000 26.36951 ? 451 HOH B O   1 
HETATM 5190 O O   . HOH L 7 .   ? 3.48600   -20.30500 21.46900  1.000 29.43715 ? 452 HOH B O   1 
HETATM 5191 O O   . HOH L 7 .   ? 10.20300  -5.20800  44.38200  1.000 39.25720 ? 453 HOH B O   1 
HETATM 5192 O O   . HOH L 7 .   ? -18.38400 -11.08500 19.37500  1.000 42.57627 ? 454 HOH B O   1 
HETATM 5193 O O   . HOH L 7 .   ? -13.27100 -18.07900 18.52400  1.000 33.55447 ? 455 HOH B O   1 
HETATM 5194 O O   . HOH L 7 .   ? -7.00200  -10.94600 31.73700  1.000 30.00532 ? 456 HOH B O   1 
HETATM 5195 O O   . HOH L 7 .   ? -2.54700  -30.70500 33.82200  1.000 47.57375 ? 457 HOH B O   1 
HETATM 5196 O O   . HOH L 7 .   ? 13.70500  -21.07200 24.45900  1.000 25.73486 ? 458 HOH B O   1 
HETATM 5197 O O   . HOH L 7 .   ? 6.30300   -8.39900  37.71200  1.000 31.45097 ? 459 HOH B O   1 
HETATM 5198 O O   . HOH L 7 .   ? -15.94300 -11.46900 28.82100  1.000 34.25329 ? 460 HOH B O   1 
HETATM 5199 O O   . HOH L 7 .   ? -15.31600 -10.78100 21.74700  1.000 27.05331 ? 461 HOH B O   1 
HETATM 5200 O O   . HOH L 7 .   ? 11.88300  -5.06700  28.86300  1.000 43.72441 ? 462 HOH B O   1 
HETATM 5201 O O   . HOH L 7 .   ? 29.931    -11.245   26.736    1.000 46.48193 ? 463 HOH B O   1 
HETATM 5202 O O   . HOH L 7 .   ? 3.23200   -27.10300 30.49900  1.000 34.57574 ? 464 HOH B O   1 
HETATM 5203 O O   . HOH L 7 .   ? -9.22600  -3.82800  23.49600  1.000 49.68595 ? 465 HOH B O   1 
HETATM 5204 O O   . HOH L 7 .   ? -13.45100 -11.54200 19.82200  1.000 33.17115 ? 466 HOH B O   1 
HETATM 5205 O O   . HOH L 7 .   ? 25.90800  -7.31400  33.90500  1.000 37.44346 ? 467 HOH B O   1 
HETATM 5206 O O   . HOH L 7 .   ? 3.28500   -2.54200  24.48100  1.000 32.62728 ? 468 HOH B O   1 
HETATM 5207 O O   . HOH L 7 .   ? 12.82200  -31.85600 33.00300  1.000 38.10612 ? 469 HOH B O   1 
HETATM 5208 O O   . HOH L 7 .   ? -8.33000  -10.34500 13.83300  1.000 46.69193 ? 470 HOH B O   1 
HETATM 5209 O O   . HOH L 7 .   ? 22.38800  -23.58500 38.97400  1.000 42.03927 ? 471 HOH B O   1 
HETATM 5210 O O   . HOH L 7 .   ? -1.37200  -14.86200 21.53000  1.000 32.12556 ? 472 HOH B O   1 
HETATM 5211 O O   . HOH L 7 .   ? 3.68800   -16.73000 21.11900  1.000 30.66010 ? 473 HOH B O   1 
HETATM 5212 O O   . HOH L 7 .   ? 3.37400   -7.67100  36.98700  1.000 38.14647 ? 474 HOH B O   1 
HETATM 5213 O O   . HOH L 7 .   ? 16.49900  -28.45200 31.66900  1.000 42.44765 ? 475 HOH B O   1 
HETATM 5214 O O   . HOH L 7 .   ? 2.79100   -4.48300  40.25700  1.000 46.08042 ? 476 HOH B O   1 
HETATM 5215 O O   . HOH L 7 .   ? 4.64800   -30.53500 27.52600  1.000 50.68210 ? 477 HOH B O   1 
HETATM 5216 O O   . HOH L 7 .   ? 0.57700   -29.62600 31.32600  1.000 39.15899 ? 478 HOH B O   1 
HETATM 5217 O O   . HOH L 7 .   ? -13.50800 -14.53900 33.98200  1.000 29.02434 ? 479 HOH B O   1 
HETATM 5218 O O   . HOH L 7 .   ? 15.93400  -25.07400 22.41500  1.000 40.55785 ? 480 HOH B O   1 
HETATM 5219 O O   . HOH L 7 .   ? 25.60500  -19.23300 31.11300  1.000 39.95754 ? 481 HOH B O   1 
HETATM 5220 O O   . HOH L 7 .   ? 28.48500  -10.51800 33.00800  1.000 41.01124 ? 482 HOH B O   1 
HETATM 5221 O O   . HOH L 7 .   ? 0.58300   -8.76200  22.42400  1.000 25.06056 ? 483 HOH B O   1 
HETATM 5222 O O   . HOH L 7 .   ? -13.84200 -22.32100 22.38200  1.000 26.96507 ? 484 HOH B O   1 
HETATM 5223 O O   . HOH L 7 .   ? 2.09300   -8.32600  38.52800  1.000 36.41736 ? 485 HOH B O   1 
HETATM 5224 O O   . HOH L 7 .   ? -0.42000  -26.04000 20.76200  1.000 35.31992 ? 486 HOH B O   1 
HETATM 5225 O O   . HOH L 7 .   ? 0.37400   -13.10200 20.64700  1.000 26.40352 ? 487 HOH B O   1 
HETATM 5226 O O   . HOH L 7 .   ? 3.89700   -27.26500 23.07600  1.000 29.11737 ? 488 HOH B O   1 
HETATM 5227 O O   . HOH L 7 .   ? 27.84600  -16.90000 38.11100  1.000 42.19428 ? 489 HOH B O   1 
HETATM 5228 O O   . HOH L 7 .   ? 26.72400  -20.07800 37.55100  1.000 45.23759 ? 490 HOH B O   1 
HETATM 5229 O O   . HOH L 7 .   ? 16.66100  -7.36000  23.27800  1.000 31.92760 ? 491 HOH B O   1 
HETATM 5230 O O   . HOH L 7 .   ? 18.97700  -4.96500  33.01000  1.000 44.37260 ? 492 HOH B O   1 
HETATM 5231 O O   . HOH L 7 .   ? -7.04900  -14.07700 46.60400  1.000 42.53458 ? 493 HOH B O   1 
HETATM 5232 O O   . HOH L 7 .   ? -10.26900 -6.62200  24.75500  1.000 37.35584 ? 494 HOH B O   1 
HETATM 5233 O O   . HOH L 7 .   ? -13.04000 -13.48400 31.91000  1.000 37.98631 ? 495 HOH B O   1 
HETATM 5234 O O   . HOH L 7 .   ? 9.60800   -24.41200 24.86100  1.000 40.90307 ? 496 HOH B O   1 
HETATM 5235 O O   . HOH L 7 .   ? -9.10100  -34.14800 28.47500  1.000 56.96356 ? 497 HOH B O   1 
HETATM 5236 O O   . HOH L 7 .   ? 18.51100  -4.35900  43.90900  1.000 45.36317 ? 498 HOH B O   1 
HETATM 5237 O O   . HOH L 7 .   ? -11.45600 -4.97300  26.50100  1.000 45.37669 ? 499 HOH B O   1 
HETATM 5238 O O   . HOH L 7 .   ? 10.96300  0.27100   32.99100  1.000 52.13909 ? 500 HOH B O   1 
HETATM 5239 O O   . HOH L 7 .   ? 14.39500  -25.20600 29.24500  1.000 29.73974 ? 501 HOH B O   1 
HETATM 5240 O O   . HOH L 7 .   ? 5.73000   -21.94000 50.65400  1.000 44.04676 ? 502 HOH B O   1 
HETATM 5241 O O   . HOH L 7 .   ? -12.58400 -14.63800 38.73600  1.000 31.16201 ? 503 HOH B O   1 
HETATM 5242 O O   . HOH L 7 .   ? -0.50000  -23.38400 50.43600  1.000 55.24668 ? 504 HOH B O   1 
HETATM 5243 O O   . HOH L 7 .   ? 7.87500   3.65800   32.64600  1.000 51.26885 ? 505 HOH B O   1 
HETATM 5244 O O   . HOH L 7 .   ? 23.15200  -21.03500 24.81100  1.000 43.09331 ? 506 HOH B O   1 
HETATM 5245 O O   . HOH L 7 .   ? -1.19600  -28.41400 22.39400  1.000 32.35447 ? 507 HOH B O   1 
HETATM 5246 O O   . HOH L 7 .   ? -22.474   -15.313   40.731    1.000 49.70347 ? 508 HOH B O   1 
HETATM 5247 O O   . HOH L 7 .   ? -11.26200 0.37600   14.74200  1.000 50.40709 ? 509 HOH B O   1 
HETATM 5248 O O   . HOH L 7 .   ? 26.09100  -13.89900 25.48400  1.000 19.55209 ? 510 HOH B O   1 
HETATM 5249 O O   . HOH L 7 .   ? 0.26000   -33.07200 33.73600  1.000 52.60622 ? 511 HOH B O   1 
HETATM 5250 O O   . HOH L 7 .   ? -14.34900 -32.56300 35.16200  1.000 58.51621 ? 512 HOH B O   1 
HETATM 5251 O O   . HOH L 7 .   ? -16.82500 -22.39700 44.51900  1.000 58.76592 ? 513 HOH B O   1 
HETATM 5252 O O   . HOH L 7 .   ? 12.86800  -31.59400 38.98600  1.000 44.49996 ? 514 HOH B O   1 
HETATM 5253 O O   . HOH L 7 .   ? 16.58700  -5.73400  40.27200  1.000 44.22769 ? 515 HOH B O   1 
HETATM 5254 O O   . HOH L 7 .   ? -2.47600  -23.28000 50.70600  1.000 45.39021 ? 516 HOH B O   1 
HETATM 5255 O O   . HOH L 7 .   ? -15.02700 -8.04900  25.62800  1.000 37.83566 ? 517 HOH B O   1 
HETATM 5256 O O   . HOH L 7 .   ? -12.07900 -10.51400 35.07000  1.000 50.68266 ? 518 HOH B O   1 
HETATM 5257 O O   . HOH L 7 .   ? 7.78800   3.95100   30.22000  1.000 50.09499 ? 519 HOH B O   1 
HETATM 5258 O O   . HOH L 7 .   ? 3.31000   -7.81100  17.36900  1.000 35.82695 ? 520 HOH B O   1 
HETATM 5259 O O   . HOH L 7 .   ? 22.30800  -23.77200 28.45800  1.000 44.10538 ? 521 HOH B O   1 
HETATM 5260 O O   . HOH L 7 .   ? -9.25500  -13.56600 34.43200  1.000 37.58621 ? 522 HOH B O   1 
HETATM 5261 O O   . HOH L 7 .   ? 5.85800   -3.85500  36.29700  1.000 47.78845 ? 523 HOH B O   1 
HETATM 5262 O O   . HOH L 7 .   ? -7.12500  -9.60100  34.71700  1.000 52.70528 ? 524 HOH B O   1 
HETATM 5263 O O   . HOH L 7 .   ? 5.53600   -33.85100 33.58700  1.000 42.94506 ? 525 HOH B O   1 
HETATM 5264 O O   . HOH L 7 .   ? -1.79900  -36.43500 45.26500  1.000 54.75808 ? 526 HOH B O   1 
HETATM 5265 O O   . HOH L 7 .   ? -5.67500  -34.53300 27.22100  1.000 47.85486 ? 527 HOH B O   1 
HETATM 5266 O O   . HOH L 7 .   ? 6.91700   -3.18700  21.45200  1.000 41.08094 ? 528 HOH B O   1 
HETATM 5267 O O   . HOH L 7 .   ? -5.92100  -33.64800 34.43200  1.000 65.03331 ? 529 HOH B O   1 
HETATM 5268 O O   . HOH L 7 .   ? 25.85800  -7.74500  36.97200  1.000 45.48700 ? 530 HOH B O   1 
HETATM 5269 O O   . HOH L 7 .   ? -4.28500  -31.12700 21.55200  1.000 51.57537 ? 531 HOH B O   1 
HETATM 5270 O O   . HOH L 7 .   ? -7.55700  -12.43100 45.03900  1.000 53.68202 ? 532 HOH B O   1 
HETATM 5271 O O   . HOH L 7 .   ? -24.812   -23.052   28.467    1.000 47.35297 ? 533 HOH B O   1 
HETATM 5272 O O   . HOH L 7 .   ? -18.75400 -22.91600 43.30100  1.000 55.50239 ? 534 HOH B O   1 
HETATM 5273 O O   . HOH L 7 .   ? 0.94600   -9.92900  20.41500  1.000 40.86504 ? 535 HOH B O   1 
HETATM 5274 O O   . HOH L 7 .   ? 5.41200   -27.34300 19.47600  1.000 47.99691 ? 536 HOH B O   1 
HETATM 5275 O O   . HOH L 7 .   ? 21.79600  -9.11400  16.04300  1.000 40.63999 ? 537 HOH B O   1 
HETATM 5276 O O   . HOH L 7 .   ? -23.250   -17.576   41.633    1.000 45.29415 ? 538 HOH B O   1 
HETATM 5277 O O   . HOH L 7 .   ? 10.97300  -17.85500 49.28400  1.000 50.42023 ? 539 HOH B O   1 
HETATM 5278 O O   . HOH L 7 .   ? -14.05800 -33.62200 33.20300  1.000 55.74214 ? 540 HOH B O   1 
HETATM 5279 O O   . HOH L 7 .   ? -11.44900 -13.53200 36.74000  1.000 44.67792 ? 541 HOH B O   1 
HETATM 5280 O O   . HOH L 7 .   ? 15.61000  -22.40700 50.03800  1.000 49.55998 ? 542 HOH B O   1 
HETATM 5281 O O   . HOH L 7 .   ? -6.77200  -35.18100 33.55100  1.000 69.17569 ? 543 HOH B O   1 
HETATM 5282 O O   . HOH L 7 .   ? -13.16300 -22.62900 17.71000  1.000 39.86424 ? 544 HOH B O   1 
HETATM 5283 O O   . HOH L 7 .   ? 0.32300   -17.76900 21.65900  1.000 37.95880 ? 545 HOH B O   1 
HETATM 5284 O O   . HOH L 7 .   ? -5.44300  -33.19200 31.79200  1.000 55.19437 ? 546 HOH B O   1 
HETATM 5285 O O   . HOH L 7 .   ? 5.93500   -33.09900 31.87100  1.000 58.21226 ? 547 HOH B O   1 
HETATM 5286 O O   . HOH L 7 .   ? -4.35700  -19.16500 49.02500  1.000 45.65320 ? 548 HOH B O   1 
HETATM 5287 O O   . HOH L 7 .   ? 22.97100  -24.64300 47.36500  1.000 56.87654 ? 549 HOH B O   1 
HETATM 5288 O O   . HOH L 7 .   ? 25.24900  -15.83200 43.13800  1.000 40.34097 ? 550 HOH B O   1 
HETATM 5289 O O   . HOH L 7 .   ? 6.00500   -3.26100  19.21300  1.000 45.87091 ? 551 HOH B O   1 
HETATM 5290 O O   . HOH L 7 .   ? -6.46400  -16.69800 48.87800  1.000 52.02810 ? 552 HOH B O   1 
HETATM 5291 O O   . HOH L 7 .   ? 14.77400  -16.47200 55.87000  1.000 59.49191 ? 553 HOH B O   1 
HETATM 5292 O O   . HOH L 7 .   ? 0.40700   0.71500   23.39900  1.000 54.81617 ? 554 HOH B O   1 
HETATM 5293 O O   . HOH L 7 .   ? -15.72600 -26.09500 54.20100  1.000 54.87422 ? 555 HOH B O   1 
HETATM 5294 O O   . HOH L 7 .   ? 10.58400  2.87900   17.29100  1.000 66.83217 ? 556 HOH B O   1 
HETATM 5295 O O   . HOH L 7 .   ? -7.05100  5.56700   35.74900  1.000 53.76332 ? 557 HOH B O   1 
HETATM 5296 O O   . HOH L 7 .   ? 8.05200   6.36100   24.42600  1.000 56.86369 ? 558 HOH B O   1 
HETATM 5297 O O   . HOH L 7 .   ? 17.35200  -1.70900  39.47700  1.000 57.58860 ? 559 HOH B O   1 
HETATM 5298 O O   . HOH L 7 .   ? -8.87900  8.12100   34.95700  1.000 61.42799 ? 560 HOH B O   1 
HETATM 5299 O O   . HOH L 7 .   ? -16.12400 -30.67800 56.96000  1.000 53.40892 ? 561 HOH B O   1 
HETATM 5300 O O   . HOH L 7 .   ? 18.37800  1.09900   38.08100  1.000 55.33541 ? 562 HOH B O   1 
HETATM 5301 O O   . HOH L 7 .   ? -11.86100 4.44200   11.37300  1.000 65.85299 ? 563 HOH B O   1 
HETATM 5302 O O   . HOH L 7 .   ? 3.55500   3.89400   17.60300  1.000 63.60785 ? 564 HOH B O   1 
HETATM 5303 O O   . HOH L 7 .   ? -3.03200  8.32400   13.85700  1.000 54.21083 ? 565 HOH B O   1 
HETATM 5304 O O   . HOH M 7 .   ? 17.13800  -27.20900 23.82300  1.000 45.64894 ? 401 HOH H O   1 
HETATM 5305 O O   . HOH M 7 .   ? 5.96900   -23.45000 16.58400  1.000 25.71580 ? 402 HOH H O   1 
HETATM 5306 O O   . HOH M 7 .   ? 50.62800  -10.09200 -13.26400 1.000 45.47833 ? 403 HOH H O   1 
HETATM 5307 O O   . HOH M 7 .   ? 22.81900  -16.72900 -5.75700  1.000 31.94970 ? 404 HOH H O   1 
HETATM 5308 O O   . HOH M 7 .   ? 23.10200  -15.06300 20.12400  1.000 26.58534 ? 405 HOH H O   1 
HETATM 5309 O O   . HOH M 7 .   ? 23.16200  -29.58300 22.31500  1.000 33.65030 ? 406 HOH H O   1 
HETATM 5310 O O   . HOH M 7 .   ? 50.13700  -1.69000  -17.95100 1.000 47.32365 ? 407 HOH H O   1 
HETATM 5311 O O   . HOH M 7 .   ? 32.82100  -13.22500 16.43800  1.000 43.60309 ? 408 HOH H O   1 
HETATM 5312 O O   . HOH M 7 .   ? 49.59500  2.19300   -12.66400 1.000 37.42791 ? 409 HOH H O   1 
HETATM 5313 O O   . HOH M 7 .   ? 32.08900  -14.00000 0.48200   1.000 44.88264 ? 410 HOH H O   1 
HETATM 5314 O O   . HOH M 7 .   ? 38.13200  -18.54200 -25.19800 1.000 41.77442 ? 411 HOH H O   1 
HETATM 5315 O O   . HOH M 7 .   ? 4.19100   -12.25800 20.55900  1.000 32.31067 ? 412 HOH H O   1 
HETATM 5316 O O   . HOH M 7 .   ? 13.78500  -20.22200 14.44000  1.000 17.66664 ? 413 HOH H O   1 
HETATM 5317 O O   . HOH M 7 .   ? 33.05900  -15.59000 -12.77300 1.000 24.52722 ? 414 HOH H O   1 
HETATM 5318 O O   . HOH M 7 .   ? 31.31900  -32.68300 20.82000  1.000 37.90968 ? 415 HOH H O   1 
HETATM 5319 O O   . HOH M 7 .   ? 21.28800  -37.72900 -8.59600  1.000 32.37319 ? 416 HOH H O   1 
HETATM 5320 O O   . HOH M 7 .   ? 20.62600  -17.19300 15.17400  1.000 17.78076 ? 417 HOH H O   1 
HETATM 5321 O O   . HOH M 7 .   ? 20.61000  -33.75000 -9.29000  1.000 24.76590 ? 418 HOH H O   1 
HETATM 5322 O O   . HOH M 7 .   ? 34.83100  10.31400  -22.04800 1.000 40.01176 ? 419 HOH H O   1 
HETATM 5323 O O   . HOH M 7 .   ? 16.52200  -23.67400 8.46900   1.000 24.45885 ? 420 HOH H O   1 
HETATM 5324 O O   . HOH M 7 .   ? 18.33500  -16.18400 -9.55200  1.000 45.46327 ? 421 HOH H O   1 
HETATM 5325 O O   . HOH M 7 .   ? 31.12100  -40.07000 -2.09000  1.000 22.05095 ? 422 HOH H O   1 
HETATM 5326 O O   . HOH M 7 .   ? 30.20200  -16.11000 4.23200   1.000 24.51938 ? 423 HOH H O   1 
HETATM 5327 O O   . HOH M 7 .   ? 28.12700  -39.50000 -5.04400  1.000 20.63155 ? 424 HOH H O   1 
HETATM 5328 O O   . HOH M 7 .   ? 37.71600  -23.44200 1.15300   1.000 35.06189 ? 425 HOH H O   1 
HETATM 5329 O O   . HOH M 7 .   ? 34.54800  -26.05200 -1.04100  1.000 23.40771 ? 426 HOH H O   1 
HETATM 5330 O O   . HOH M 7 .   ? 9.35900   -18.45600 21.09100  1.000 14.47950 ? 427 HOH H O   1 
HETATM 5331 O O   . HOH M 7 .   ? 33.44400  -7.34700  -19.28800 1.000 25.63476 ? 428 HOH H O   1 
HETATM 5332 O O   . HOH M 7 .   ? 13.63900  -19.46200 22.05500  1.000 15.68421 ? 429 HOH H O   1 
HETATM 5333 O O   . HOH M 7 .   ? 21.81800  -26.04900 -11.72400 1.000 20.95213 ? 430 HOH H O   1 
HETATM 5334 O O   . HOH M 7 .   ? 16.22100  -17.88500 13.90700  1.000 12.72132 ? 431 HOH H O   1 
HETATM 5335 O O   . HOH M 7 .   ? 30.76100  -8.12100  1.91600   1.000 56.69485 ? 432 HOH H O   1 
HETATM 5336 O O   . HOH M 7 .   ? 33.32400  11.92500  -20.07900 1.000 42.30879 ? 433 HOH H O   1 
HETATM 5337 O O   . HOH M 7 .   ? 46.34100  -1.80700  -22.26600 1.000 40.23901 ? 434 HOH H O   1 
HETATM 5338 O O   . HOH M 7 .   ? 31.70500  -29.73500 9.60600   1.000 32.56937 ? 435 HOH H O   1 
HETATM 5339 O O   . HOH M 7 .   ? 25.68900  -17.70700 21.95700  1.000 29.72206 ? 436 HOH H O   1 
HETATM 5340 O O   . HOH M 7 .   ? 38.92300  -2.95100  -4.56200  1.000 30.77260 ? 437 HOH H O   1 
HETATM 5341 O O   . HOH M 7 .   ? 27.49700  -14.18200 -15.82300 1.000 31.79407 ? 438 HOH H O   1 
HETATM 5342 O O   . HOH M 7 .   ? 10.52400  -28.11700 11.45800  1.000 27.09153 ? 439 HOH H O   1 
HETATM 5343 O O   . HOH M 7 .   ? 32.19400  -23.18800 -9.22100  1.000 22.79589 ? 440 HOH H O   1 
HETATM 5344 O O   . HOH M 7 .   ? 35.56800  -31.67700 -12.99700 1.000 33.05528 ? 441 HOH H O   1 
HETATM 5345 O O   . HOH M 7 .   ? 47.64400  -4.51100  -4.79500  1.000 36.77251 ? 442 HOH H O   1 
HETATM 5346 O O   . HOH M 7 .   ? 19.79000  -11.49300 8.58100   1.000 20.83604 ? 443 HOH H O   1 
HETATM 5347 O O   . HOH M 7 .   ? 35.34300  -5.86300  -7.81600  1.000 34.46983 ? 444 HOH H O   1 
HETATM 5348 O O   . HOH M 7 .   ? 29.60300  -13.68900 -13.26400 1.000 32.96678 ? 445 HOH H O   1 
HETATM 5349 O O   . HOH M 7 .   ? 26.42100  -27.60300 -14.49200 1.000 32.41375 ? 446 HOH H O   1 
HETATM 5350 O O   . HOH M 7 .   ? 31.52600  -32.41200 10.46700  1.000 32.84214 ? 447 HOH H O   1 
HETATM 5351 O O   . HOH M 7 .   ? 12.17000  -22.21500 15.52700  1.000 23.95894 ? 448 HOH H O   1 
HETATM 5352 O O   . HOH M 7 .   ? 26.40900  -41.63800 -8.22300  1.000 33.61963 ? 449 HOH H O   1 
HETATM 5353 O O   . HOH M 7 .   ? 37.03900  -17.28900 -6.94000  1.000 27.65371 ? 450 HOH H O   1 
HETATM 5354 O O   . HOH M 7 .   ? 17.72100  -36.76500 13.45000  1.000 45.16093 ? 451 HOH H O   1 
HETATM 5355 O O   . HOH M 7 .   ? 38.82300  -26.19000 -18.71800 1.000 43.26728 ? 452 HOH H O   1 
HETATM 5356 O O   . HOH M 7 .   ? 31.90300  -32.87000 16.25000  1.000 29.90253 ? 453 HOH H O   1 
HETATM 5357 O O   . HOH M 7 .   ? 22.90100  -40.90300 -4.04300  1.000 29.90849 ? 454 HOH H O   1 
HETATM 5358 O O   . HOH M 7 .   ? 33.75300  -17.80600 10.44800  1.000 24.06190 ? 455 HOH H O   1 
HETATM 5359 O O   . HOH M 7 .   ? 32.46200  -9.58400  -18.67700 1.000 27.14237 ? 456 HOH H O   1 
HETATM 5360 O O   . HOH M 7 .   ? 35.28100  -22.31700 12.49100  1.000 31.76190 ? 457 HOH H O   1 
HETATM 5361 O O   . HOH M 7 .   ? 21.01900  -16.76400 -9.97600  1.000 37.99489 ? 458 HOH H O   1 
HETATM 5362 O O   . HOH M 7 .   ? 23.55400  -27.16300 17.55500  1.000 24.90697 ? 459 HOH H O   1 
HETATM 5363 O O   . HOH M 7 .   ? 16.12500  -37.80800 -3.82300  1.000 42.96098 ? 460 HOH H O   1 
HETATM 5364 O O   . HOH M 7 .   ? 42.87900  7.30100   -7.16200  1.000 50.59257 ? 461 HOH H O   1 
HETATM 5365 O O   . HOH M 7 .   ? 16.29200  -29.37600 18.91100  1.000 33.90482 ? 462 HOH H O   1 
HETATM 5366 O O   . HOH M 7 .   ? 32.82100  -34.11300 4.18300   1.000 39.18069 ? 463 HOH H O   1 
HETATM 5367 O O   . HOH M 7 .   ? 33.67800  -1.10000  -5.52400  1.000 46.61325 ? 464 HOH H O   1 
HETATM 5368 O O   . HOH M 7 .   ? 47.96600  7.02200   -2.52900  1.000 61.78379 ? 465 HOH H O   1 
HETATM 5369 O O   . HOH M 7 .   ? 33.14700  -25.90200 19.21300  1.000 36.08724 ? 466 HOH H O   1 
HETATM 5370 O O   . HOH M 7 .   ? 42.58300  -18.71900 -4.23200  1.000 37.99589 ? 467 HOH H O   1 
HETATM 5371 O O   . HOH M 7 .   ? 34.47500  -34.45900 -8.08300  1.000 28.44468 ? 468 HOH H O   1 
HETATM 5372 O O   . HOH M 7 .   ? 30.01400  -13.54000 19.83000  1.000 29.84174 ? 469 HOH H O   1 
HETATM 5373 O O   . HOH M 7 .   ? 26.029    -34.419   17.371    1.000 30.48593 ? 470 HOH H O   1 
HETATM 5374 O O   . HOH M 7 .   ? 17.29000  -35.40400 -5.62300  1.000 39.07244 ? 471 HOH H O   1 
HETATM 5375 O O   . HOH M 7 .   ? 26.00600  -36.48200 10.97300  1.000 21.88213 ? 472 HOH H O   1 
HETATM 5376 O O   . HOH M 7 .   ? 21.07700  -35.46700 22.26600  1.000 35.88422 ? 473 HOH H O   1 
HETATM 5377 O O   . HOH M 7 .   ? 31.59200  -10.16700 -11.73100 1.000 30.28609 ? 474 HOH H O   1 
HETATM 5378 O O   . HOH M 7 .   ? 38.19600  -32.54800 12.23100  1.000 43.67577 ? 475 HOH H O   1 
HETATM 5379 O O   . HOH M 7 .   ? 22.12600  -38.85000 6.03700   1.000 27.34701 ? 476 HOH H O   1 
HETATM 5380 O O   . HOH M 7 .   ? 18.39200  -31.52600 -7.54800  1.000 32.35161 ? 477 HOH H O   1 
HETATM 5381 O O   . HOH M 7 .   ? 27.23500  -15.60900 -20.94800 1.000 37.72810 ? 478 HOH H O   1 
HETATM 5382 O O   . HOH M 7 .   ? 30.40600  -31.65200 -18.05600 1.000 37.12643 ? 479 HOH H O   1 
HETATM 5383 O O   . HOH M 7 .   ? 27.01600  -19.72000 -17.32400 1.000 30.92555 ? 480 HOH H O   1 
HETATM 5384 O O   . HOH M 7 .   ? 29.20500  -13.89500 8.35100   1.000 23.05348 ? 481 HOH H O   1 
HETATM 5385 O O   . HOH M 7 .   ? 33.21700  -31.60200 -3.23300  1.000 24.36640 ? 482 HOH H O   1 
HETATM 5386 O O   . HOH M 7 .   ? 36.35700  -12.38700 -23.77100 1.000 37.50547 ? 483 HOH H O   1 
HETATM 5387 O O   . HOH M 7 .   ? 31.21400  1.64200   -8.59200  1.000 37.49939 ? 484 HOH H O   1 
HETATM 5388 O O   . HOH M 7 .   ? 17.82700  -27.42700 -9.18600  1.000 28.90326 ? 485 HOH H O   1 
HETATM 5389 O O   . HOH M 7 .   ? 37.28300  -36.76500 -8.40900  1.000 46.15549 ? 486 HOH H O   1 
HETATM 5390 O O   . HOH M 7 .   ? 37.93900  -24.03800 -3.56700  1.000 34.03240 ? 487 HOH H O   1 
HETATM 5391 O O   . HOH M 7 .   ? 11.42700  -22.24700 21.54800  1.000 14.33587 ? 488 HOH H O   1 
HETATM 5392 O O   . HOH M 7 .   ? 21.50600  -11.59100 16.39100  1.000 34.43772 ? 489 HOH H O   1 
HETATM 5393 O O   . HOH M 7 .   ? 23.00600  -18.41700 -8.15400  1.000 23.09872 ? 490 HOH H O   1 
HETATM 5394 O O   . HOH M 7 .   ? 37.50600  -26.41500 -8.62200  1.000 28.05262 ? 491 HOH H O   1 
HETATM 5395 O O   . HOH M 7 .   ? 15.58700  -36.71300 12.18300  1.000 46.85449 ? 492 HOH H O   1 
HETATM 5396 O O   . HOH M 7 .   ? 28.26300  -33.70300 5.93700   1.000 29.31153 ? 493 HOH H O   1 
HETATM 5397 O O   . HOH M 7 .   ? 10.81100  -37.88700 3.17100   1.000 45.89868 ? 494 HOH H O   1 
HETATM 5398 O O   . HOH M 7 .   ? 42.55400  -8.17500  -2.22800  1.000 44.18918 ? 495 HOH H O   1 
HETATM 5399 O O   . HOH M 7 .   ? 16.61500  -27.01000 20.81900  1.000 46.09326 ? 496 HOH H O   1 
HETATM 5400 O O   . HOH M 7 .   ? 30.88100  -21.93500 -13.53600 1.000 21.75842 ? 497 HOH H O   1 
HETATM 5401 O O   . HOH M 7 .   ? 40.46300  -29.99200 -12.79500 1.000 42.28377 ? 498 HOH H O   1 
HETATM 5402 O O   . HOH M 7 .   ? 12.93500  -27.51600 20.29700  1.000 31.70945 ? 499 HOH H O   1 
HETATM 5403 O O   . HOH M 7 .   ? 37.32000  -31.98700 -10.77400 1.000 38.38087 ? 500 HOH H O   1 
HETATM 5404 O O   . HOH M 7 .   ? 11.64600  -26.80600 -1.79200  1.000 25.65142 ? 501 HOH H O   1 
HETATM 5405 O O   . HOH M 7 .   ? 15.69100  -30.07800 -6.36200  1.000 36.10482 ? 502 HOH H O   1 
HETATM 5406 O O   . HOH M 7 .   ? 26.95000  -9.54500  3.33900   1.000 27.50986 ? 503 HOH H O   1 
HETATM 5407 O O   . HOH M 7 .   ? 27.63000  -20.38800 22.23100  1.000 31.49102 ? 504 HOH H O   1 
HETATM 5408 O O   . HOH M 7 .   ? 8.05300   -27.48100 14.61400  1.000 27.19830 ? 505 HOH H O   1 
HETATM 5409 O O   . HOH M 7 .   ? 39.23600  -17.21500 5.73500   1.000 48.46267 ? 506 HOH H O   1 
HETATM 5410 O O   . HOH M 7 .   ? 34.96200  -26.64300 -5.05500  1.000 37.91193 ? 507 HOH H O   1 
HETATM 5411 O O   . HOH M 7 .   ? 32.58800  -13.40400 -11.11500 1.000 28.67511 ? 508 HOH H O   1 
HETATM 5412 O O   . HOH M 7 .   ? 34.99400  -23.10700 5.35100   1.000 40.28027 ? 509 HOH H O   1 
HETATM 5413 O O   . HOH M 7 .   ? 5.99700   -27.83700 11.54700  1.000 37.35451 ? 510 HOH H O   1 
HETATM 5414 O O   . HOH M 7 .   ? 30.30900  -28.04000 -17.96700 1.000 43.16325 ? 511 HOH H O   1 
HETATM 5415 O O   . HOH M 7 .   ? 14.99800  -37.84400 -1.64900  1.000 38.88491 ? 512 HOH H O   1 
HETATM 5416 O O   . HOH M 7 .   ? 46.04100  -20.64000 -17.83300 1.000 47.10893 ? 513 HOH H O   1 
HETATM 5417 O O   . HOH M 7 .   ? 28.14600  -13.34700 5.95100   1.000 28.58157 ? 514 HOH H O   1 
HETATM 5418 O O   . HOH M 7 .   ? 21.63200  -28.56100 19.54400  1.000 31.51912 ? 515 HOH H O   1 
HETATM 5419 O O   . HOH M 7 .   ? 31.60200  -4.21100  -9.11500  1.000 26.35289 ? 516 HOH H O   1 
HETATM 5420 O O   . HOH M 7 .   ? 25.90400  -14.37700 18.03200  1.000 31.95553 ? 517 HOH H O   1 
HETATM 5421 O O   . HOH M 7 .   ? 19.90400  -37.34800 12.61800  1.000 48.23586 ? 518 HOH H O   1 
HETATM 5422 O O   . HOH M 7 .   ? 37.60900  -28.50700 7.17900   1.000 35.49604 ? 519 HOH H O   1 
HETATM 5423 O O   . HOH M 7 .   ? 32.31600  -38.34000 -13.59800 1.000 41.58628 ? 520 HOH H O   1 
HETATM 5424 O O   . HOH M 7 .   ? 34.77300  -8.84300  -7.72400  1.000 26.77380 ? 521 HOH H O   1 
HETATM 5425 O O   . HOH M 7 .   ? 40.03100  -25.03200 -4.75700  1.000 40.17838 ? 522 HOH H O   1 
HETATM 5426 O O   . HOH M 7 .   ? 32.60400  -38.85600 -4.73400  1.000 32.17794 ? 523 HOH H O   1 
HETATM 5427 O O   . HOH M 7 .   ? 49.59600  -15.65000 -5.66300  1.000 41.91503 ? 524 HOH H O   1 
HETATM 5428 O O   . HOH M 7 .   ? 34.420    -36.240   -0.190    1.000 28.43743 ? 525 HOH H O   1 
HETATM 5429 O O   . HOH M 7 .   ? 28.28300  -20.50700 -13.31000 1.000 34.91591 ? 526 HOH H O   1 
HETATM 5430 O O   . HOH M 7 .   ? 32.89900  -18.04200 0.76200   1.000 36.72207 ? 527 HOH H O   1 
HETATM 5431 O O   . HOH M 7 .   ? 21.99000  -37.64100 8.87400   1.000 42.80345 ? 528 HOH H O   1 
HETATM 5432 O O   . HOH M 7 .   ? 52.42100  -6.54900  -12.77700 1.000 39.60968 ? 529 HOH H O   1 
HETATM 5433 O O   . HOH M 7 .   ? 33.992    -35.999   -2.400    1.000 44.41411 ? 530 HOH H O   1 
HETATM 5434 O O   . HOH M 7 .   ? 38.48000  -29.99700 -19.78600 1.000 49.29505 ? 531 HOH H O   1 
HETATM 5435 O O   . HOH M 7 .   ? 49.16000  12.74900  -14.35800 1.000 50.18728 ? 532 HOH H O   1 
HETATM 5436 O O   . HOH M 7 .   ? 23.79000  -13.09600 17.95700  1.000 38.84152 ? 533 HOH H O   1 
HETATM 5437 O O   . HOH M 7 .   ? 35.07700  -17.04100 8.57600   1.000 44.15398 ? 534 HOH H O   1 
HETATM 5438 O O   . HOH M 7 .   ? 25.75600  -13.21500 10.38700  1.000 38.00184 ? 535 HOH H O   1 
HETATM 5439 O O   . HOH M 7 .   ? 35.36700  -31.08100 6.71200   1.000 48.57366 ? 536 HOH H O   1 
HETATM 5440 O O   . HOH M 7 .   ? 33.84500  -16.26500 -27.86900 1.000 46.99357 ? 537 HOH H O   1 
HETATM 5441 O O   . HOH M 7 .   ? 26.76100  -11.87700 -19.11400 1.000 43.30214 ? 538 HOH H O   1 
HETATM 5442 O O   . HOH M 7 .   ? 35.78800  -16.08600 -4.62700  1.000 48.00097 ? 539 HOH H O   1 
HETATM 5443 O O   . HOH M 7 .   ? 31.29500  3.74800   -6.54900  1.000 43.29624 ? 540 HOH H O   1 
HETATM 5444 O O   . HOH M 7 .   ? 24.82400  -33.83600 -15.36900 1.000 27.12963 ? 541 HOH H O   1 
HETATM 5445 O O   . HOH M 7 .   ? 26.91000  -14.38500 20.61500  1.000 41.45072 ? 542 HOH H O   1 
HETATM 5446 O O   . HOH M 7 .   ? 29.84500  3.88500   -9.96800  1.000 35.22140 ? 543 HOH H O   1 
HETATM 5447 O O   . HOH M 7 .   ? 41.184    15.629    -11.726   1.000 50.38405 ? 544 HOH H O   1 
HETATM 5448 O O   . HOH M 7 .   ? 19.55100  -36.15800 -8.55500  1.000 43.58686 ? 545 HOH H O   1 
HETATM 5449 O O   . HOH M 7 .   ? 32.12000  -34.20600 6.67400   1.000 48.76422 ? 546 HOH H O   1 
HETATM 5450 O O   . HOH M 7 .   ? 13.95600  -22.86600 22.10000  1.000 36.94495 ? 547 HOH H O   1 
HETATM 5451 O O   . HOH M 7 .   ? 10.85500  -39.51500 6.61800   1.000 42.39081 ? 548 HOH H O   1 
HETATM 5452 O O   . HOH M 7 .   ? 52.56900  5.07100   -10.84700 1.000 55.89253 ? 549 HOH H O   1 
HETATM 5453 O O   . HOH M 7 .   ? 39.05000  -23.77300 12.77300  1.000 41.51958 ? 550 HOH H O   1 
HETATM 5454 O O   . HOH M 7 .   ? 42.82300  -6.10400  -22.62500 1.000 40.38354 ? 551 HOH H O   1 
HETATM 5455 O O   . HOH M 7 .   ? 43.480    -15.336   -2.004    1.000 48.26742 ? 552 HOH H O   1 
HETATM 5456 O O   . HOH M 7 .   ? 42.92100  -25.37800 -5.98200  1.000 50.47438 ? 553 HOH H O   1 
HETATM 5457 O O   . HOH M 7 .   ? 23.24900  -43.32300 -7.95800  1.000 49.75932 ? 554 HOH H O   1 
HETATM 5458 O O   . HOH M 7 .   ? 45.65100  -24.98200 -10.83100 1.000 51.83040 ? 555 HOH H O   1 
HETATM 5459 O O   . HOH M 7 .   ? 34.78500  -29.50700 2.30900   1.000 30.90863 ? 556 HOH H O   1 
HETATM 5460 O O   . HOH M 7 .   ? 25.28200  -12.62700 16.63500  1.000 42.10302 ? 557 HOH H O   1 
HETATM 5461 O O   . HOH M 7 .   ? 3.17700   -16.36900 15.56000  1.000 33.14546 ? 558 HOH H O   1 
HETATM 5462 O O   . HOH M 7 .   ? 49.56000  -3.41400  -1.41600  1.000 39.73447 ? 559 HOH H O   1 
HETATM 5463 O O   . HOH M 7 .   ? 13.45100  -36.45800 10.64100  1.000 38.84659 ? 560 HOH H O   1 
HETATM 5464 O O   . HOH M 7 .   ? 19.72100  -10.29400 13.69900  1.000 42.90053 ? 561 HOH H O   1 
HETATM 5465 O O   . HOH M 7 .   ? 49.07600  -18.28200 -7.59900  1.000 38.80912 ? 562 HOH H O   1 
HETATM 5466 O O   . HOH M 7 .   ? 34.53500  -18.89600 -0.76800  1.000 42.45977 ? 563 HOH H O   1 
HETATM 5467 O O   . HOH M 7 .   ? 24.26800  -38.94500 -10.94100 1.000 39.86182 ? 564 HOH H O   1 
HETATM 5468 O O   . HOH M 7 .   ? 43.27400  -26.54300 -9.08400  1.000 45.56701 ? 565 HOH H O   1 
HETATM 5469 O O   . HOH M 7 .   ? 16.34200  -36.22400 8.06200   1.000 35.85472 ? 566 HOH H O   1 
HETATM 5470 O O   . HOH M 7 .   ? 42.10100  17.85900  -17.21100 1.000 40.08001 ? 567 HOH H O   1 
HETATM 5471 O O   . HOH M 7 .   ? 33.39600  -33.13900 21.99300  1.000 42.02067 ? 568 HOH H O   1 
HETATM 5472 O O   . HOH M 7 .   ? 32.87500  -10.18000 -8.74300  1.000 46.29602 ? 569 HOH H O   1 
HETATM 5473 O O   . HOH M 7 .   ? 39.88700  -19.47700 -26.45000 1.000 53.61396 ? 570 HOH H O   1 
HETATM 5474 O O   . HOH M 7 .   ? 15.28800  -23.61300 -6.86500  1.000 35.68411 ? 571 HOH H O   1 
HETATM 5475 O O   . HOH M 7 .   ? 26.41300  -16.48300 -23.95300 1.000 41.81175 ? 572 HOH H O   1 
HETATM 5476 O O   . HOH M 7 .   ? 36.52800  -32.72800 -8.72800  1.000 43.75382 ? 573 HOH H O   1 
HETATM 5477 O O   . HOH M 7 .   ? 14.62300  -15.61700 -10.19700 1.000 46.48076 ? 574 HOH H O   1 
HETATM 5478 O O   . HOH M 7 .   ? 34.96100  -38.34500 -4.49700  1.000 49.42628 ? 575 HOH H O   1 
HETATM 5479 O O   . HOH M 7 .   ? 33.78700  -27.70500 -3.51000  1.000 32.67646 ? 576 HOH H O   1 
HETATM 5480 O O   . HOH M 7 .   ? 17.60500  -33.44800 -9.08700  1.000 42.48889 ? 577 HOH H O   1 
HETATM 5481 O O   . HOH M 7 .   ? 18.67600  -25.75000 -11.76400 1.000 40.56331 ? 578 HOH H O   1 
HETATM 5482 O O   . HOH M 7 .   ? 45.25800  -26.09600 -6.42600  1.000 46.78533 ? 579 HOH H O   1 
HETATM 5483 O O   . HOH M 7 .   ? 10.99700  -40.19500 4.22300   1.000 45.04639 ? 580 HOH H O   1 
HETATM 5484 O O   . HOH M 7 .   ? 35.42400  -26.06700 -20.30900 1.000 41.47184 ? 581 HOH H O   1 
HETATM 5485 O O   . HOH M 7 .   ? 9.09900   -32.95000 -2.73400  1.000 42.32932 ? 582 HOH H O   1 
HETATM 5486 O O   . HOH M 7 .   ? 29.30100  -9.92500  -10.99000 1.000 43.36688 ? 583 HOH H O   1 
HETATM 5487 O O   . HOH M 7 .   ? 26.71500  -43.92000 -6.67500  1.000 44.29678 ? 584 HOH H O   1 
HETATM 5488 O O   . HOH M 7 .   ? 34.96200  -32.68800 -3.61200  1.000 43.67296 ? 585 HOH H O   1 
HETATM 5489 O O   . HOH M 7 .   ? 26.62400  -21.84900 -14.16500 1.000 37.43572 ? 586 HOH H O   1 
HETATM 5490 O O   . HOH M 7 .   ? 43.61900  4.92300   -3.98500  1.000 45.49756 ? 587 HOH H O   1 
HETATM 5491 O O   . HOH M 7 .   ? 20.99600  -41.37800 -3.83400  1.000 48.27609 ? 588 HOH H O   1 
HETATM 5492 O O   . HOH M 7 .   ? 20.19700  -13.02500 -7.46800  1.000 38.45100 ? 589 HOH H O   1 
HETATM 5493 O O   . HOH M 7 .   ? 8.45200   -36.48400 3.60800   1.000 53.29080 ? 590 HOH H O   1 
HETATM 5494 O O   . HOH M 7 .   ? 36.182    -34.675   1.654     1.000 37.13152 ? 591 HOH H O   1 
HETATM 5495 O O   . HOH M 7 .   ? 36.03200  -3.44300  -5.75800  1.000 47.70984 ? 592 HOH H O   1 
HETATM 5496 O O   . HOH M 7 .   ? 31.06300  -2.61400  -6.39600  1.000 49.95541 ? 593 HOH H O   1 
HETATM 5497 O O   . HOH M 7 .   ? 27.35500  -10.42600 5.93700   1.000 39.50752 ? 594 HOH H O   1 
HETATM 5498 O O   . HOH M 7 .   ? 3.83200   -10.76200 18.59000  1.000 33.77314 ? 595 HOH H O   1 
HETATM 5499 O O   . HOH M 7 .   ? 41.85400  -36.00500 -12.65700 1.000 55.35858 ? 596 HOH H O   1 
HETATM 5500 O O   . HOH M 7 .   ? 35.808    -11.292   16.605    1.000 44.13491 ? 597 HOH H O   1 
HETATM 5501 O O   . HOH M 7 .   ? 33.49500  -27.18500 -20.92800 1.000 43.49681 ? 598 HOH H O   1 
HETATM 5502 O O   . HOH M 7 .   ? 23.49200  -32.50300 23.56000  1.000 40.96499 ? 599 HOH H O   1 
HETATM 5503 O O   . HOH M 7 .   ? 25.08800  -17.91500 -9.99300  1.000 41.14801 ? 600 HOH H O   1 
HETATM 5504 O O   . HOH M 7 .   ? 27.87500  -11.99800 -11.57100 1.000 41.42859 ? 601 HOH H O   1 
HETATM 5505 O O   . HOH M 7 .   ? 24.95800  -45.50700 -6.07300  1.000 58.04845 ? 602 HOH H O   1 
HETATM 5506 O O   . HOH M 7 .   ? 24.81300  -13.11100 -15.19900 1.000 44.80585 ? 603 HOH H O   1 
HETATM 5507 O O   . HOH M 7 .   ? 27.25700  -33.88300 -16.70400 1.000 56.85343 ? 604 HOH H O   1 
HETATM 5508 O O   . HOH M 7 .   ? 23.34000  -20.57100 -16.66000 1.000 54.54076 ? 605 HOH H O   1 
HETATM 5509 O O   . HOH M 7 .   ? 38.82700  -30.27000 3.39100   1.000 49.05999 ? 606 HOH H O   1 
HETATM 5510 O O   . HOH M 7 .   ? 30.21500  -9.37100  7.76000   1.000 58.32697 ? 607 HOH H O   1 
HETATM 5511 O O   . HOH M 7 .   ? 50.42300  10.23500  -0.31100  1.000 59.64602 ? 608 HOH H O   1 
HETATM 5512 O O   . HOH M 7 .   ? 39.85200  -21.53300 -33.03500 1.000 51.08151 ? 609 HOH H O   1 
HETATM 5513 O O   . HOH M 7 .   ? 22.27600  -18.57100 -21.48600 1.000 57.48885 ? 610 HOH H O   1 
HETATM 5514 O O   . HOH M 7 .   ? 21.56300  -24.17900 -19.79700 1.000 62.12165 ? 611 HOH H O   1 
HETATM 5515 O O   . HOH M 7 .   ? 18.60300  -16.56900 -21.13300 1.000 50.10870 ? 612 HOH H O   1 
HETATM 5516 O O   . HOH M 7 .   ? 17.04000  -20.84600 -22.94100 1.000 57.01545 ? 613 HOH H O   1 
HETATM 5517 O O   . HOH N 7 .   ? 0.33800   -11.47700 11.91900  1.000 34.04608 ? 401 HOH L O   1 
HETATM 5518 O O   . HOH N 7 .   ? 45.40400  -16.72000 -33.08700 1.000 48.88857 ? 402 HOH L O   1 
HETATM 5519 O O   . HOH N 7 .   ? 34.08900  -10.95900 -27.78500 1.000 27.53817 ? 403 HOH L O   1 
HETATM 5520 O O   . HOH N 7 .   ? 10.08300  5.29200   8.68200   1.000 52.72390 ? 404 HOH L O   1 
HETATM 5521 O O   . HOH N 7 .   ? 19.25900  -7.59200  12.12700  1.000 39.80122 ? 405 HOH L O   1 
HETATM 5522 O O   . HOH N 7 .   ? 44.56200  -2.01500  -23.81800 1.000 43.13446 ? 406 HOH L O   1 
HETATM 5523 O O   . HOH N 7 .   ? -0.81100  -25.41300 0.54600   1.000 40.03128 ? 407 HOH L O   1 
HETATM 5524 O O   . HOH N 7 .   ? 37.98800  -11.46300 -25.48000 1.000 41.45211 ? 408 HOH L O   1 
HETATM 5525 O O   . HOH N 7 .   ? 28.02100  -4.70000  -28.67000 1.000 31.56045 ? 409 HOH L O   1 
HETATM 5526 O O   . HOH N 7 .   ? 46.90100  -2.43300  -31.23700 1.000 45.22488 ? 410 HOH L O   1 
HETATM 5527 O O   . HOH N 7 .   ? 33.09400  4.41300   -12.75000 1.000 31.86742 ? 411 HOH L O   1 
HETATM 5528 O O   . HOH N 7 .   ? 3.27100   -3.71100  4.77600   1.000 22.63213 ? 412 HOH L O   1 
HETATM 5529 O O   . HOH N 7 .   ? 21.53400  -2.35600  -3.19200  1.000 20.11948 ? 413 HOH L O   1 
HETATM 5530 O O   . HOH N 7 .   ? -0.72000  -6.51000  -1.07300  1.000 39.46114 ? 414 HOH L O   1 
HETATM 5531 O O   . HOH N 7 .   ? 37.74500  9.22200   -26.52700 1.000 57.59995 ? 415 HOH L O   1 
HETATM 5532 O O   . HOH N 7 .   ? 1.09100   -19.50400 -3.80000  1.000 25.08396 ? 416 HOH L O   1 
HETATM 5533 O O   . HOH N 7 .   ? 13.95600  1.22300   -19.16800 1.000 55.14949 ? 417 HOH L O   1 
HETATM 5534 O O   . HOH N 7 .   ? -3.89400  -9.75100  10.01800  1.000 44.36685 ? 418 HOH L O   1 
HETATM 5535 O O   . HOH N 7 .   ? 18.54600  -13.51900 -5.19600  1.000 29.21296 ? 419 HOH L O   1 
HETATM 5536 O O   . HOH N 7 .   ? 6.85400   0.89000   5.82100   1.000 31.12391 ? 420 HOH L O   1 
HETATM 5537 O O   . HOH N 7 .   ? 41.49000  -4.52000  -24.85100 1.000 34.05257 ? 421 HOH L O   1 
HETATM 5538 O O   . HOH N 7 .   ? 25.27000  2.91600   -31.70600 1.000 34.53667 ? 422 HOH L O   1 
HETATM 5539 O O   . HOH N 7 .   ? 29.02000  8.81700   -34.01300 1.000 37.15583 ? 423 HOH L O   1 
HETATM 5540 O O   . HOH N 7 .   ? 32.19900  -7.35700  -22.77500 1.000 22.98787 ? 424 HOH L O   1 
HETATM 5541 O O   . HOH N 7 .   ? 22.49500  -0.62700  -37.73400 1.000 51.46445 ? 425 HOH L O   1 
HETATM 5542 O O   . HOH N 7 .   ? -3.00000  -24.25500 6.85800   1.000 33.04158 ? 426 HOH L O   1 
HETATM 5543 O O   . HOH N 7 .   ? 28.16500  8.90500   -16.99100 1.000 33.80216 ? 427 HOH L O   1 
HETATM 5544 O O   . HOH N 7 .   ? 27.04300  1.99300   -13.18100 1.000 21.39369 ? 428 HOH L O   1 
HETATM 5545 O O   . HOH N 7 .   ? 29.93700  -7.69100  -33.44000 1.000 32.63553 ? 429 HOH L O   1 
HETATM 5546 O O   . HOH N 7 .   ? 19.56200  2.89800   4.28100   1.000 28.19855 ? 430 HOH L O   1 
HETATM 5547 O O   . HOH N 7 .   ? 14.59900  8.79100   -8.26800  1.000 29.47068 ? 431 HOH L O   1 
HETATM 5548 O O   . HOH N 7 .   ? 24.69600  -3.00700  -6.82100  1.000 29.99780 ? 432 HOH L O   1 
HETATM 5549 O O   . HOH N 7 .   ? -4.26200  -15.12300 -0.82400  1.000 40.68188 ? 433 HOH L O   1 
HETATM 5550 O O   . HOH N 7 .   ? 20.15800  2.05100   -6.89800  1.000 17.76997 ? 434 HOH L O   1 
HETATM 5551 O O   . HOH N 7 .   ? 6.73000   -3.99300  10.57800  1.000 21.32525 ? 435 HOH L O   1 
HETATM 5552 O O   . HOH N 7 .   ? 8.94800   -24.45800 8.22700   1.000 33.09329 ? 436 HOH L O   1 
HETATM 5553 O O   . HOH N 7 .   ? 30.549    8.571     -15.983   1.000 32.56866 ? 437 HOH L O   1 
HETATM 5554 O O   . HOH N 7 .   ? 8.51700   -16.96000 11.02900  1.000 19.63198 ? 438 HOH L O   1 
HETATM 5555 O O   . HOH N 7 .   ? 7.99800   6.85200   -9.78100  1.000 43.21039 ? 439 HOH L O   1 
HETATM 5556 O O   . HOH N 7 .   ? 33.99300  -12.11700 -25.01300 1.000 28.87725 ? 440 HOH L O   1 
HETATM 5557 O O   . HOH N 7 .   ? 17.28700  -11.61200 12.89100  1.000 18.19267 ? 441 HOH L O   1 
HETATM 5558 O O   . HOH N 7 .   ? 4.40900   -9.63600  6.00200   1.000 19.76953 ? 442 HOH L O   1 
HETATM 5559 O O   . HOH N 7 .   ? 1.59500   -31.17500 -1.86200  1.000 51.34758 ? 443 HOH L O   1 
HETATM 5560 O O   . HOH N 7 .   ? 25.41400  -8.93700  -18.64800 1.000 29.41363 ? 444 HOH L O   1 
HETATM 5561 O O   . HOH N 7 .   ? 11.65400  -22.40300 -1.77300  1.000 20.36730 ? 445 HOH L O   1 
HETATM 5562 O O   . HOH N 7 .   ? 23.34400  12.21100  -13.25800 1.000 25.79121 ? 446 HOH L O   1 
HETATM 5563 O O   . HOH N 7 .   ? 18.83300  -8.89500  9.99100   1.000 30.86464 ? 447 HOH L O   1 
HETATM 5564 O O   . HOH N 7 .   ? 44.36600  -7.11000  -24.04700 1.000 36.33305 ? 448 HOH L O   1 
HETATM 5565 O O   . HOH N 7 .   ? 21.67200  -8.97300  0.95400   1.000 18.26261 ? 449 HOH L O   1 
HETATM 5566 O O   . HOH N 7 .   ? 23.51400  -8.25300  -15.78900 1.000 32.30007 ? 450 HOH L O   1 
HETATM 5567 O O   . HOH N 7 .   ? 2.65400   -19.47900 -8.25900  1.000 43.74739 ? 451 HOH L O   1 
HETATM 5568 O O   . HOH N 7 .   ? 12.95400  11.37100  -6.16300  1.000 33.33824 ? 452 HOH L O   1 
HETATM 5569 O O   . HOH N 7 .   ? 16.59900  -11.90400 -8.62500  1.000 40.40678 ? 453 HOH L O   1 
HETATM 5570 O O   . HOH N 7 .   ? 3.51900   -2.94200  6.85600   1.000 39.25503 ? 454 HOH L O   1 
HETATM 5571 O O   . HOH N 7 .   ? 21.68000  -4.99800  -14.85300 1.000 21.70001 ? 455 HOH L O   1 
HETATM 5572 O O   . HOH N 7 .   ? 0.24700   -19.86600 15.88500  1.000 47.20818 ? 456 HOH L O   1 
HETATM 5573 O O   . HOH N 7 .   ? 5.95000   -3.83400  -11.61700 1.000 33.39232 ? 457 HOH L O   1 
HETATM 5574 O O   . HOH N 7 .   ? 12.49500  -24.84700 -0.10600  1.000 17.80850 ? 458 HOH L O   1 
HETATM 5575 O O   . HOH N 7 .   ? 22.47300  -3.65700  -25.11600 1.000 44.13322 ? 459 HOH L O   1 
HETATM 5576 O O   . HOH N 7 .   ? 50.67300  -15.28100 -32.76500 1.000 58.92754 ? 460 HOH L O   1 
HETATM 5577 O O   . HOH N 7 .   ? 25.95100  -5.49200  -3.16000  1.000 43.91081 ? 461 HOH L O   1 
HETATM 5578 O O   . HOH N 7 .   ? 0.76600   -13.07800 -5.20300  1.000 38.29129 ? 462 HOH L O   1 
HETATM 5579 O O   . HOH N 7 .   ? 11.04300  10.66700  1.64900   1.000 45.13488 ? 463 HOH L O   1 
HETATM 5580 O O   . HOH N 7 .   ? 14.94100  -14.79200 -7.89000  1.000 46.42943 ? 464 HOH L O   1 
HETATM 5581 O O   . HOH N 7 .   ? 28.77800  -4.63800  -33.44400 1.000 25.83423 ? 465 HOH L O   1 
HETATM 5582 O O   . HOH N 7 .   ? 23.29200  -11.06900 -8.80900  1.000 43.49708 ? 466 HOH L O   1 
HETATM 5583 O O   . HOH N 7 .   ? 7.41500   -21.37200 -3.30100  1.000 27.27919 ? 467 HOH L O   1 
HETATM 5584 O O   . HOH N 7 .   ? 16.91200  -8.74400  15.26400  1.000 21.05958 ? 468 HOH L O   1 
HETATM 5585 O O   . HOH N 7 .   ? 22.22200  -12.82600 7.19200   1.000 17.11023 ? 469 HOH L O   1 
HETATM 5586 O O   . HOH N 7 .   ? 2.46100   0.86800   -2.95300  1.000 47.04733 ? 470 HOH L O   1 
HETATM 5587 O O   . HOH N 7 .   ? 35.01600  -13.52000 -31.51100 1.000 38.26633 ? 471 HOH L O   1 
HETATM 5588 O O   . HOH N 7 .   ? 20.70600  7.24100   -6.81300  1.000 32.87996 ? 472 HOH L O   1 
HETATM 5589 O O   . HOH N 7 .   ? 29.02800  1.35000   -5.79100  1.000 46.14815 ? 473 HOH L O   1 
HETATM 5590 O O   . HOH N 7 .   ? 41.27700  7.03900   -34.57800 1.000 47.13285 ? 474 HOH L O   1 
HETATM 5591 O O   . HOH N 7 .   ? -1.54900  -15.33000 13.02400  1.000 38.70158 ? 475 HOH L O   1 
HETATM 5592 O O   . HOH N 7 .   ? 26.59700  -10.39700 -25.89700 1.000 26.36458 ? 476 HOH L O   1 
HETATM 5593 O O   . HOH N 7 .   ? 18.60300  4.65900   -24.13900 1.000 24.04829 ? 477 HOH L O   1 
HETATM 5594 O O   . HOH N 7 .   ? 25.19700  -13.79200 -2.47300  1.000 25.46157 ? 478 HOH L O   1 
HETATM 5595 O O   . HOH N 7 .   ? 7.44000   2.23500   7.79400   1.000 39.67210 ? 479 HOH L O   1 
HETATM 5596 O O   . HOH N 7 .   ? 31.61100  4.90300   -11.03100 1.000 37.10470 ? 480 HOH L O   1 
HETATM 5597 O O   . HOH N 7 .   ? 27.11900  -6.16400  -11.06900 1.000 24.81357 ? 481 HOH L O   1 
HETATM 5598 O O   . HOH N 7 .   ? 4.93600   -6.95900  15.58000  1.000 32.71695 ? 482 HOH L O   1 
HETATM 5599 O O   . HOH N 7 .   ? 32.51200  9.86700   -23.43400 1.000 30.09955 ? 483 HOH L O   1 
HETATM 5600 O O   . HOH N 7 .   ? 6.25200   -26.70400 2.67700   1.000 21.74535 ? 484 HOH L O   1 
HETATM 5601 O O   . HOH N 7 .   ? 4.71200   6.59600   -3.74800  1.000 32.87470 ? 485 HOH L O   1 
HETATM 5602 O O   . HOH N 7 .   ? 48.50300  5.46800   -28.11900 1.000 43.26430 ? 486 HOH L O   1 
HETATM 5603 O O   . HOH N 7 .   ? 26.69700  -0.98500  -5.97100  1.000 25.32105 ? 487 HOH L O   1 
HETATM 5604 O O   . HOH N 7 .   ? 24.75700  14.34000  -25.84700 1.000 43.91710 ? 488 HOH L O   1 
HETATM 5605 O O   . HOH N 7 .   ? 0.05800   -26.77400 -0.95900  1.000 42.64587 ? 489 HOH L O   1 
HETATM 5606 O O   . HOH N 7 .   ? 37.95800  8.39200   -30.13700 1.000 46.58518 ? 490 HOH L O   1 
HETATM 5607 O O   . HOH N 7 .   ? 23.93900  -8.85800  4.47800   1.000 36.91542 ? 491 HOH L O   1 
HETATM 5608 O O   . HOH N 7 .   ? 27.91700  -10.80800 -31.53500 1.000 39.46668 ? 492 HOH L O   1 
HETATM 5609 O O   . HOH N 7 .   ? 30.55500  5.78100   -36.15900 1.000 53.34241 ? 493 HOH L O   1 
HETATM 5610 O O   . HOH N 7 .   ? 21.90700  8.60500   -29.12000 1.000 30.27650 ? 494 HOH L O   1 
HETATM 5611 O O   . HOH N 7 .   ? 7.35000   -1.08400  -12.25400 1.000 33.99702 ? 495 HOH L O   1 
HETATM 5612 O O   . HOH N 7 .   ? 29.584    3.654     -0.949    1.000 48.17362 ? 496 HOH L O   1 
HETATM 5613 O O   . HOH N 7 .   ? -5.599    -8.211    -2.509    1.000 44.58552 ? 497 HOH L O   1 
HETATM 5614 O O   . HOH N 7 .   ? 4.28200   -11.12900 15.63700  1.000 39.84132 ? 498 HOH L O   1 
HETATM 5615 O O   . HOH N 7 .   ? 15.34600  -2.66700  -18.13800 1.000 47.70233 ? 499 HOH L O   1 
HETATM 5616 O O   . HOH N 7 .   ? 15.53100  3.68300   11.09300  1.000 33.79145 ? 500 HOH L O   1 
HETATM 5617 O O   . HOH N 7 .   ? 16.38800  0.93300   -17.00400 1.000 32.80709 ? 501 HOH L O   1 
HETATM 5618 O O   . HOH N 7 .   ? 40.09000  6.19400   -35.93600 1.000 50.01933 ? 502 HOH L O   1 
HETATM 5619 O O   . HOH N 7 .   ? 28.43100  5.16600   -7.49900  1.000 31.85165 ? 503 HOH L O   1 
HETATM 5620 O O   . HOH N 7 .   ? 10.96700  -13.07700 -9.99300  1.000 40.10084 ? 504 HOH L O   1 
HETATM 5621 O O   . HOH N 7 .   ? -0.30100  -29.17600 5.62000   1.000 45.92634 ? 505 HOH L O   1 
HETATM 5622 O O   . HOH N 7 .   ? -1.19200  -7.75300  4.15100   1.000 44.69138 ? 506 HOH L O   1 
HETATM 5623 O O   . HOH N 7 .   ? 13.34000  10.33900  0.33200   1.000 45.83016 ? 507 HOH L O   1 
HETATM 5624 O O   . HOH N 7 .   ? 18.01900  11.81500  -27.14200 1.000 48.97179 ? 508 HOH L O   1 
HETATM 5625 O O   . HOH N 7 .   ? 22.49800  13.02200  -15.62400 1.000 29.07663 ? 509 HOH L O   1 
HETATM 5626 O O   . HOH N 7 .   ? -5.73000  -13.84500 4.91500   1.000 41.95486 ? 510 HOH L O   1 
HETATM 5627 O O   . HOH N 7 .   ? -4.32900  -19.29300 -0.85800  1.000 46.59679 ? 511 HOH L O   1 
HETATM 5628 O O   . HOH N 7 .   ? 1.43400   -17.23500 13.97000  1.000 27.76443 ? 512 HOH L O   1 
HETATM 5629 O O   . HOH N 7 .   ? 8.69400   -4.31300  14.86400  1.000 21.30444 ? 513 HOH L O   1 
HETATM 5630 O O   . HOH N 7 .   ? 28.25100  -2.58300  -42.74700 1.000 49.47173 ? 514 HOH L O   1 
HETATM 5631 O O   . HOH N 7 .   ? 8.35800   10.20500  0.71800   1.000 46.15619 ? 515 HOH L O   1 
HETATM 5632 O O   . HOH N 7 .   ? 53.58900  -7.22500  -28.56600 1.000 54.83206 ? 516 HOH L O   1 
HETATM 5633 O O   . HOH N 7 .   ? 17.75400  -3.89900  -20.56300 1.000 42.29040 ? 517 HOH L O   1 
HETATM 5634 O O   . HOH N 7 .   ? 19.11200  -8.13200  -7.21200  1.000 33.47930 ? 518 HOH L O   1 
HETATM 5635 O O   . HOH N 7 .   ? 10.64400  -6.25400  16.50700  1.000 26.30867 ? 519 HOH L O   1 
HETATM 5636 O O   . HOH N 7 .   ? 20.24200  -4.56000  -12.25500 1.000 26.85300 ? 520 HOH L O   1 
HETATM 5637 O O   . HOH N 7 .   ? -5.59100  -16.43100 9.63800   1.000 40.79986 ? 521 HOH L O   1 
HETATM 5638 O O   . HOH N 7 .   ? 18.18500  10.91800  -10.31700 1.000 37.28926 ? 522 HOH L O   1 
HETATM 5639 O O   . HOH N 7 .   ? 26.80500  -11.72000 -23.94900 1.000 40.81032 ? 523 HOH L O   1 
HETATM 5640 O O   . HOH N 7 .   ? 21.43700  -6.94800  2.33100   1.000 28.06312 ? 524 HOH L O   1 
HETATM 5641 O O   . HOH N 7 .   ? 8.11900   0.44900   10.81600  1.000 46.98339 ? 525 HOH L O   1 
HETATM 5642 O O   . HOH N 7 .   ? 7.24300   -20.09400 -6.29200  1.000 36.50233 ? 526 HOH L O   1 
HETATM 5643 O O   . HOH N 7 .   ? 15.23200  3.03300   -23.09200 1.000 44.71693 ? 527 HOH L O   1 
HETATM 5644 O O   . HOH N 7 .   ? 23.75200  -1.20100  -0.53900  1.000 28.89509 ? 528 HOH L O   1 
HETATM 5645 O O   . HOH N 7 .   ? 2.52200   -10.21100 -11.15800 1.000 49.15634 ? 529 HOH L O   1 
HETATM 5646 O O   . HOH N 7 .   ? 33.79900  9.61300   -16.83800 1.000 39.42498 ? 530 HOH L O   1 
HETATM 5647 O O   . HOH N 7 .   ? 24.04900  4.79600   -36.33000 1.000 42.88475 ? 531 HOH L O   1 
HETATM 5648 O O   . HOH N 7 .   ? 51.42200  -11.83000 -37.11400 1.000 59.06189 ? 532 HOH L O   1 
HETATM 5649 O O   . HOH N 7 .   ? 23.45400  -6.88100  -23.09700 1.000 42.05344 ? 533 HOH L O   1 
HETATM 5650 O O   . HOH N 7 .   ? -7.62400  -19.07000 5.08400   1.000 33.52319 ? 534 HOH L O   1 
HETATM 5651 O O   . HOH N 7 .   ? 5.34000   -9.39900  -12.66500 1.000 35.69692 ? 535 HOH L O   1 
HETATM 5652 O O   . HOH N 7 .   ? 34.11200  -6.87400  -41.98100 1.000 45.82247 ? 536 HOH L O   1 
HETATM 5653 O O   . HOH N 7 .   ? -0.18000  -22.58100 15.00000  1.000 47.73693 ? 537 HOH L O   1 
HETATM 5654 O O   . HOH N 7 .   ? 0.60400   1.54700   -1.44500  1.000 46.50433 ? 538 HOH L O   1 
HETATM 5655 O O   . HOH N 7 .   ? 5.01300   -29.82400 8.19900   1.000 37.04339 ? 539 HOH L O   1 
HETATM 5656 O O   . HOH N 7 .   ? 11.62000  0.79800   -15.58100 1.000 49.28621 ? 540 HOH L O   1 
HETATM 5657 O O   . HOH N 7 .   ? -3.49000  -25.83600 -1.46500  1.000 47.35746 ? 541 HOH L O   1 
HETATM 5658 O O   . HOH N 7 .   ? 3.57900   -2.70500  -6.55200  1.000 37.76911 ? 542 HOH L O   1 
HETATM 5659 O O   . HOH N 7 .   ? 4.76100   -28.89800 3.36500   1.000 40.92707 ? 543 HOH L O   1 
HETATM 5660 O O   . HOH N 7 .   ? 5.98300   -30.77600 -3.79600  1.000 51.58128 ? 544 HOH L O   1 
HETATM 5661 O O   . HOH N 7 .   ? 14.33600  4.61200   7.38700   1.000 35.88050 ? 545 HOH L O   1 
HETATM 5662 O O   . HOH N 7 .   ? -5.54300  -23.59800 4.74700   1.000 52.57029 ? 546 HOH L O   1 
HETATM 5663 O O   . HOH N 7 .   ? 23.19800  -4.25700  2.98600   1.000 40.34041 ? 547 HOH L O   1 
HETATM 5664 O O   . HOH N 7 .   ? 18.91400  4.67400   6.07100   1.000 37.11561 ? 548 HOH L O   1 
HETATM 5665 O O   . HOH N 7 .   ? 28.66900  -6.51000  -5.53100  1.000 42.47685 ? 549 HOH L O   1 
HETATM 5666 O O   . HOH N 7 .   ? 30.25600  -13.79300 -30.15700 1.000 40.27166 ? 550 HOH L O   1 
HETATM 5667 O O   . HOH N 7 .   ? 15.97700  13.32800  -16.63900 1.000 31.45955 ? 551 HOH L O   1 
HETATM 5668 O O   . HOH N 7 .   ? 12.88600  -12.17500 -9.28100  1.000 37.14962 ? 552 HOH L O   1 
HETATM 5669 O O   . HOH N 7 .   ? 26.50200  -9.14900  -32.47900 1.000 34.04500 ? 553 HOH L O   1 
HETATM 5670 O O   . HOH N 7 .   ? 31.85400  8.38700   -36.74700 1.000 53.01175 ? 554 HOH L O   1 
HETATM 5671 O O   . HOH N 7 .   ? 15.10500  -0.00300  -13.99600 1.000 44.26154 ? 555 HOH L O   1 
HETATM 5672 O O   . HOH N 7 .   ? 10.34900  6.20000   12.55700  1.000 48.60325 ? 556 HOH L O   1 
HETATM 5673 O O   . HOH N 7 .   ? 27.059    9.447     -11.453   1.000 45.84685 ? 557 HOH L O   1 
HETATM 5674 O O   . HOH N 7 .   ? 22.70400  -0.17700  2.74200   1.000 35.75233 ? 558 HOH L O   1 
HETATM 5675 O O   . HOH N 7 .   ? -0.24700  -7.22800  10.68700  1.000 39.18910 ? 559 HOH L O   1 
HETATM 5676 O O   . HOH N 7 .   ? 9.48900   -3.77900  -13.89400 1.000 49.25769 ? 560 HOH L O   1 
HETATM 5677 O O   . HOH N 7 .   ? 51.184    7.430     -35.303   1.000 56.22684 ? 561 HOH L O   1 
HETATM 5678 O O   . HOH N 7 .   ? 24.93000  -6.03000  -35.57200 1.000 50.18173 ? 562 HOH L O   1 
HETATM 5679 O O   . HOH N 7 .   ? 22.90900  -1.67600  10.26000  1.000 54.17169 ? 563 HOH L O   1 
HETATM 5680 O O   . HOH N 7 .   ? 17.75100  13.63300  -30.82700 1.000 57.68133 ? 564 HOH L O   1 
HETATM 5681 O O   . HOH N 7 .   ? 21.49700  -3.67200  -21.81300 1.000 43.46636 ? 565 HOH L O   1 
HETATM 5682 O O   . HOH N 7 .   ? 6.33000   -17.54500 -9.43500  1.000 43.89427 ? 566 HOH L O   1 
HETATM 5683 O O   . HOH N 7 .   ? 14.38200  11.67500  -16.48000 1.000 38.39084 ? 567 HOH L O   1 
HETATM 5684 O O   . HOH N 7 .   ? 4.59100   -0.72300  -5.68700  1.000 41.36189 ? 568 HOH L O   1 
HETATM 5685 O O   . HOH N 7 .   ? 7.62500   -24.51600 -3.02900  1.000 44.69602 ? 569 HOH L O   1 
HETATM 5686 O O   . HOH N 7 .   ? 0.835     -6.457    -6.238    1.000 42.59245 ? 570 HOH L O   1 
HETATM 5687 O O   . HOH N 7 .   ? 19.63300  -9.45400  -13.58400 1.000 49.17461 ? 571 HOH L O   1 
HETATM 5688 O O   . HOH N 7 .   ? 33.12000  -13.02500 -29.20800 1.000 35.47140 ? 572 HOH L O   1 
HETATM 5689 O O   . HOH N 7 .   ? 44.23300  -18.75800 -30.19800 1.000 60.11025 ? 573 HOH L O   1 
HETATM 5690 O O   . HOH N 7 .   ? 20.67700  9.38700   -31.32100 1.000 36.99113 ? 574 HOH L O   1 
HETATM 5691 O O   . HOH N 7 .   ? 12.75300  9.95500   -11.76400 1.000 38.41564 ? 575 HOH L O   1 
HETATM 5692 O O   . HOH N 7 .   ? 5.95300   -19.71000 -7.55000  1.000 46.38232 ? 576 HOH L O   1 
HETATM 5693 O O   . HOH N 7 .   ? 25.95200  -2.86700  -1.78500  1.000 43.63880 ? 577 HOH L O   1 
HETATM 5694 O O   . HOH N 7 .   ? -6.37300  -23.78800 0.87500   1.000 42.30178 ? 578 HOH L O   1 
HETATM 5695 O O   . HOH N 7 .   ? 19.23500  -2.68900  -28.01800 1.000 52.66175 ? 579 HOH L O   1 
HETATM 5696 O O   . HOH N 7 .   ? 51.00300  -2.96700  -31.75400 1.000 49.91006 ? 580 HOH L O   1 
HETATM 5697 O O   . HOH N 7 .   ? 23.91400  -8.07400  -21.79300 1.000 42.21573 ? 581 HOH L O   1 
HETATM 5698 O O   . HOH N 7 .   ? 23.578    4.632     3.645     1.000 37.30876 ? 582 HOH L O   1 
HETATM 5699 O O   . HOH N 7 .   ? 19.04400  3.20000   -28.04300 1.000 42.52115 ? 583 HOH L O   1 
HETATM 5700 O O   . HOH N 7 .   ? -3.43700  -28.81900 2.42200   1.000 46.88082 ? 584 HOH L O   1 
HETATM 5701 O O   . HOH N 7 .   ? 26.92300  13.98800  -27.81300 1.000 50.01428 ? 585 HOH L O   1 
HETATM 5702 O O   . HOH N 7 .   ? 12.54700  -17.57100 -10.30500 1.000 48.56204 ? 586 HOH L O   1 
HETATM 5703 O O   . HOH N 7 .   ? 20.374    9.491     -8.054    1.000 28.54983 ? 587 HOH L O   1 
HETATM 5704 O O   . HOH N 7 .   ? 17.90400  1.98700   12.27500  1.000 44.46742 ? 588 HOH L O   1 
HETATM 5705 O O   . HOH N 7 .   ? -1.765    -17.988   -4.443    1.000 43.60055 ? 589 HOH L O   1 
HETATM 5706 O O   . HOH N 7 .   ? 26.48100  -5.01400  -8.65600  1.000 44.84273 ? 590 HOH L O   1 
HETATM 5707 O O   . HOH N 7 .   ? 34.73000  13.62600  -23.88100 1.000 60.81896 ? 591 HOH L O   1 
HETATM 5708 O O   . HOH N 7 .   ? 42.14600  -17.66500 -32.46800 1.000 48.19090 ? 592 HOH L O   1 
HETATM 5709 O O   . HOH N 7 .   ? 23.69700  -3.89300  -4.18300  1.000 33.21272 ? 593 HOH L O   1 
HETATM 5710 O O   . HOH N 7 .   ? -0.20800  -21.80300 -5.32700  1.000 36.90866 ? 594 HOH L O   1 
HETATM 5711 O O   . HOH N 7 .   ? 31.01800  11.01300  -24.70800 1.000 46.84800 ? 595 HOH L O   1 
HETATM 5712 O O   . HOH N 7 .   ? 20.99900  0.69900   4.93700   1.000 50.03875 ? 596 HOH L O   1 
HETATM 5713 O O   . HOH N 7 .   ? 28.24200  -12.67300 -7.52500  1.000 51.08895 ? 597 HOH L O   1 
HETATM 5714 O O   . HOH N 7 .   ? 20.58900  7.32100   -33.79800 1.000 46.16592 ? 598 HOH L O   1 
HETATM 5715 O O   . HOH N 7 .   ? 15.79300  9.96700   -27.69200 1.000 52.07669 ? 599 HOH L O   1 
HETATM 5716 O O   . HOH N 7 .   ? 39.00000  -15.95000 -31.22000 1.000 50.47876 ? 600 HOH L O   1 
HETATM 5717 O O   . HOH N 7 .   ? 22.43400  -1.82200  -39.74900 1.000 56.33916 ? 601 HOH L O   1 
HETATM 5718 O O   . HOH N 7 .   ? 20.54300  -5.48200  -25.49000 1.000 50.84211 ? 602 HOH L O   1 
HETATM 5719 O O   . HOH N 7 .   ? 51.42000  0.06300   -30.18100 1.000 53.90256 ? 603 HOH L O   1 
HETATM 5720 O O   . HOH N 7 .   ? 33.30800  -4.46000  1.93500   1.000 45.44996 ? 604 HOH L O   1 
HETATM 5721 O O   . HOH N 7 .   ? 8.00100   -10.96800 -15.79700 1.000 64.25709 ? 605 HOH L O   1 
HETATM 5722 O O   . HOH N 7 .   ? 25.10200  8.36700   -40.71700 1.000 46.33560 ? 606 HOH L O   1 
HETATM 5723 O O   . HOH N 7 .   ? 4.94900   1.47000   13.40200  1.000 56.08313 ? 607 HOH L O   1 
HETATM 5724 O O   . HOH N 7 .   ? -2.27100  5.79200   9.53800   1.000 40.55271 ? 608 HOH L O   1 
HETATM 5725 O O   . HOH N 7 .   ? 3.28600   8.23800   13.34500  1.000 50.24592 ? 609 HOH L O   1 
HETATM 5726 O O   . HOH N 7 .   ? 3.11600   2.44700   15.03200  1.000 62.10675 ? 610 HOH L O   1 
HETATM 5727 O O   . HOH N 7 .   ? 0.34200   4.15500   13.13800  1.000 56.28521 ? 611 HOH L O   1 
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